SGTCid condition conc unit PCT1|YGR202C.score PCT1|YGR202C.strain.pval PCT1|YGR202C.strain.significant PCT1|YGR202C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_221 trifluoperazine 10.304 µM 9.74514622649797 3.32391646558546e-26 yes 1 9.67500435967643e-23 62 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1754 st042065 16.137 µM 8.68781816739899 3.05905955943119e-21 yes 2 1.84733261223848e-18 46 1126236 YIL048W NEO1 SGTC_1750 st081859 2.357 µM 8.28506226186636 1.69961140782422e-19 yes 3 5.9023656145136e-17 66 5291695 SGTC_16 erodoxin 22.806 µM 6.72532776060844 1.69338482635571e-13 yes 4 8.75988114708261e-12 21 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2688 kanamycin b 96.69 µM 6.55221417646267 6.61249311518276e-13 yes 5 2.83450772557652e-11 127 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_987 1497-1013 404 µM 4.36119482510594 1.08803522213655e-06 yes 6 6.46770604786984e-06 8 1676435 SGTC_2794 7785382 27.27 µM 4.31626035122217 1.37920141175102e-06 yes 7 7.93473973415581e-06 23 2205081 SGTC_535 2293-4129 48.2 µM 4.02756802000851 5.99804159504116e-06 yes 8 2.81783830286556e-05 56 396118 YIL048W NEO1 SGTC_439 amiodarone 34.4 µM 4.01051754305561 6.52312659659475e-06 yes 9 3.02928991931439e-05 94 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_8 0354-0001 70 µM 3.72714609442543 2.51023494790819e-05 yes 10 9.68301069725265e-05 86 4993152 SGTC_699 0375-0592 111 µM 3.46431749428185 8.09390302612651e-05 yes 11 0.000265789354011817 39 762578 SGTC_649 1123-0311 367 µM 3.44605944963193 8.75495032062344e-05 yes 12 0.000284412603402716 101 693629 YIL048W NEO1 SGTC_1803 st050068 52.4 µM 3.30580581516594 0.000158081094356868 yes 13 0.000473518476701763 233 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2491 paeonol 100 µM 3.28007323129027 0.000175771777344444 yes 14 0.000518900723864274 17 11092 Increases levels of cortical cytochrome oxidase. SGTC_207 4185-0010 4.486 µM 3.27745160501289 0.000177674469828757 yes 15 0.00052374342612087 128 3761753 SGTC_988 1497-1057 103 µM 3.2736692135996 0.000180453573990735 yes 16 0.00053080403298949 27 3533044 SGTC_986 1493-0483 84 µM 3.23202333551911 0.000213861524796668 yes 17 0.00061458508909492 35 40079 SGTC_2021 4019055 173 µM 3.19705595678534 0.000246283731809986 yes 18 0.000694189952585111 194 44827708 YER133W GLC7 SGTC_1338 1486-1223 76 µM 3.1914707882541 0.00025186844429009 yes 19 0.000707752119463419 46 3444526 SGTC_705 1124-0212 310 µM 3.16489261694415 0.000280099282842058 yes 20 0.000775700980131266 44 9554485 SGTC_1525 8-methoxypsoralen 92.5 µM 3.11946884429685 0.000335268002198432 yes 21 0.000905887100412199 77 4114 Related to psoralen; DNA damaging agent. SGTC_1634 st006576 41 µM 3.08398575447334 0.000385218414969061 yes 22 0.00102123687620679 55 3915356 SGTC_968 1309-0633 340 µM 3.07654413181687 0.000396534620869512 yes 23 0.00104707650194644 43 3761976 SGTC_1630 st005209 31.3 µM 3.06375269408651 0.000416709795162019 yes 24 0.0010928975966852 66 3367314 SGTC_985 1493-0307 8.71 µM 3.05018975332851 0.000439138964821896 yes 25 0.0011434841251404 46 3278274 SGTC_798 1287-0182 476 µM 2.99367409442517 0.000545183422080995 yes 26 0.00137820101186033 67 1649755 SGTC_146 3448-8650 53.125 µM 2.97104228673646 0.000593936304927467 yes 27 0.00148395455944004 226 2891488 YIL048W NEO1 SGTC_916 4466-0038 42 nM 2.92815483057625 0.000697539092688341 yes 28 0.00170490099640118 155 5722064 YGL116W CDC20 SGTC_1800 st050079 29.0735 µM 2.92082766556439 0.000716823319348639 yes 29 0.00174551438524465 232 3645560 SGTC_2107 5363541 170.161 µM 2.91621093945861 0.000729225126131887 yes 30 0.00177155433222931 41 244052 SGTC_2435 5706476 10.6 µM 2.89673820185516 0.000783741002491442 yes 31 0.00188532134500875 74 5725375 SGTC_2335 9018011 154.17 µM 2.89118580191123 0.000799959298612078 yes 32 0.00191895571436766 80 6458208 SGTC_2249 haloperidol 116.36 µM 2.80261895589329 0.00110409236872166 no 33 0.00253447595811282 213 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_313 3474-0040 5.03 µM 2.79842122872549 0.00112084819018715 no 34 0.00256765467472461 165 1043375 YIL048W NEO1 SGTC_320 4092-0846 5.34 µM 2.76790882074843 0.00124981958323086 no 35 0.00282086185606733 106 1359356 SGTC_2015 5119600 184 µM 2.75992794509422 0.00128572351646523 no 36 0.00289070557005133 94 2828786 SGTC_1239 0337-0584 35.4 µM 2.68803167551738 0.00165430662430457 no 37 0.00359372891338009 150 914301 YML130C ERO1 SGTC_2693 st077581 40.7 µM 2.68370202884223 0.00167931199035037 no 38 0.00364059841435524 126 25238761 SGTC_1346 1488-2224 62.4 µM 2.65139547812915 0.00187703282461127 no 39 0.00400799597143989 74 3722427 SGTC_1315 1237-0019 3.69 µM 2.65056556898031 0.00188237987119328 no 40 0.00401785639383751 73 825140 SGTC_2121 5257820 149.641 µM 2.64532992742105 0.00191643310674624 no 41 0.00408056504167359 85 791256 SGTC_3037 9091026 49.47 µM 2.64327023950714 0.00192998227381174 no 42 0.0041054735840638 253 25236398 YIL048W NEO1 SGTC_1818 st052136 56.3 µM 2.6370921875838 0.00197114674640774 no 43 0.00418100516201587 147 674169 SGTC_2492 derrusnin 100 µM 2.63361525055779 0.00199466273514614 no 44 0.0042240579447923 43 1715307 Part of coumarin class of compounds. SGTC_910 3454-3003 490 µM 2.61818006845905 0.00210216299927007 no 45 0.00442000714894306 105 820824 SGTC_1508 1080-0625 72.9 µM 2.57766720057552 0.00240977027959957 no 46 0.00497348730274484 77 767111 SGTC_538 2922-0838 53.3 µM 2.54186336741377 0.00271492427920415 no 47 0.00551316336937771 139 777039 SGTC_2856 9022925 19.48 µM 2.44111249711958 0.00376955294778432 no 48 0.00732104638949594 143 4944862 SGTC_1061 3448-9325 110 µM 2.42662415502046 0.00394821950159903 no 49 0.00762001740421023 107 723482 SGTC_161 4065-0411 162.148 µM 2.38462539613791 0.00450976824096604 no 50 0.00854826017006067 211 1906281 YLR208W SEC13 SGTC_715 0868-0130 184 µM 2.36252493795613 0.00483302599446495 no 51 0.00907546009985733 95 2876258 SGTC_1344 1488-0097 29.1 µM 2.33648485682529 0.00524029366984068 no 52 0.00973299296663267 138 747966 SGTC_859 0439-0102 54.6 µM 2.33269226347365 0.00530209017225743 no 53 0.00983215126902097 137 610143 SGTC_1760 st045453 10.4495 µM 2.3301790398775 0.00534339685663658 no 54 0.00989834515120728 250 3323419 YIL048W NEO1 SGTC_1313 1220-0047 237 µM 2.32067678520581 0.00550217146346466 no 55 0.0101521472802914 177 3528706 SGTC_2374 9071832 200 µM 2.30212552964813 0.00582427267410398 no 56 0.0106640470435039 106 17381698 SGTC_1938 st074717 56.4 µM 2.26088851799334 0.00660084096025754 no 57 0.0118830806569262 103 17250979 SGTC_702 1488-0190 94 µM 2.25718134973096 0.00667494788854172 no 58 0.0119983726514076 123 949357 SGTC_2167 5876490 200 µM 2.23242540479314 0.007188948080584 no 59 0.0127934301527881 182 686534 SGTC_172 1112-0046 2.638 µM 2.22957395409971 0.00725033831569788 no 60 0.0128878702921994 158 2802135 YIL048W NEO1 SGTC_746 1095-0025 46.6 µM 2.21216160280131 0.0076353443916196 no 61 0.0134777504386887 161 6749286 SGTC_1263 0774-1208 64.8 µM 2.20530440713676 0.00779183605069285 no 62 0.0137163703994108 235 906585 SGTC_1305 1181-0477 144 µM 2.19486449978661 0.00803551047178053 no 63 0.0140866595145171 157 6252086 SGTC_308 4092-1169 104 µM 2.17802521931948 0.00844267882603231 no 64 0.0147020796183915 212 2268590 YDL196W YDL196W SGTC_669 0108-0021 26.2 µM 2.16088934960059 0.00887549847717269 no 65 0.0153519439043382 308 17201 SGTC_1506 4226-2149 212 µM 2.15969848889192 0.00890628743488538 no 66 0.0153980091319645 213 991114 SGTC_1088 bifonazole 369 nM 2.13808636335357 0.00948154288240285 no 67 0.0162548672479189 157 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2859 9028643 45.46 µM 2.13777375481255 0.00949009666406737 no 68 0.0162675550460267 131 17151580 SGTC_740 k014-0057 261 µM 2.13226865108115 0.00964184011963641 no 69 0.016492383814543 201 4012779 SGTC_1257 0669-0121 16 µM 2.13154135204755 0.0096620452310545 no 70 0.0165222847508787 203 4307855 SGTC_989 1501-0895 10.3 µM 2.1082210449163 0.0103298217721981 no 71 0.0175059368700615 138 2830112 SGTC_2848 9016370 25.97 µM 2.09785776354934 0.0106392634585655 no 72 0.0179588560121556 202 7894410 SGTC_1350 1495-0454 146 µM 2.09308914927036 0.0107843433007621 no 73 0.0181705985750036 229 1069057 SGTC_1673 st016611 27.3 µM 2.08858993248477 0.0109228030415545 no 74 0.0183723261060582 252 5226799 SGTC_1611 st001856 99.4 µM 2.0864526157182 0.0109891174332508 no 75 0.0184688215741905 189 647478 SGTC_301 4119-0100 24.5 µM 2.07963019851422 0.0112031450605922 no 76 0.0187797324528799 269 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2497 7-hydroxyflavone 100 µM 2.07760511227788 0.011267368033859 no 77 0.0188728724698755 189 5281894 SGTC_2812 7970281 58.44 µM 2.0703532882297 0.011499982090215 no 78 0.0192096363890553 230 2233435 SGTC_1686 st019653 115.5 µM 2.0596634533875 0.0118504785700541 no 79 0.019715362771739 167 97252 SGTC_2430 5571206 200 µM 2.05763020372756 0.0119181833583977 no 80 0.0198128225002719 245 1731771 SGTC_1079 idarubicin 2.36 µM 2.05329331451994 0.0120637185260599 no 81 0.020022069437044 175 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1343 1487-0095 224 µM 2.028571017554 0.012923107674612 no 82 0.0212510015215734 173 4560101 YGL055W OLE1 SGTC_742 0kpi-0133 140 µM 2.0270212524231 0.0129787009501378 no 83 0.0213301196368271 217 2728852 SGTC_1332 1480-0653 17.5 µM 2.01302307288071 0.0134902822486559 no 84 0.0220561010521913 221 5749438 SGTC_875 0709-0210 25.7 µM 2.01231546310437 0.0135165986582515 no 85 0.0220933467155321 242 6251364 SGTC_1507 4075-3230 155 µM 1.99344978475136 0.0142347482471554 no 86 0.0231061084950487 148 659771 SGTC_457 grayanotoxin iii 135 µM 1.9765249895325 0.0149067480652625 no 87 0.0240476741620097 339 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2006 4011487 200 µM 1.95913111814925 0.0156256144409545 no 88 0.0250487166801662 322 45595294 SGTC_1262 0737-0114 49.6 µM 1.95339554463597 0.0158690898925785 no 89 0.0253863718805868 273 765919 SGTC_2898 9056270 58.44 µM 1.92750506988918 0.0170090320143522 no 90 0.026958358420393 169 19154699 SGTC_1631 benzylvanillin 81.9 µM 1.92300500641947 0.0172141454240914 no 91 0.027239710559715 271 75506 SGTC_1561 5-methoxyflavone 52.9 µM 1.92202321369479 0.017259175407753 no 92 0.0273014184333773 150 94525 SGTC_169 k015-0017 16.025 µM 1.92087594983051 0.0173119221972979 no 93 0.0273736742264557 216 1840002 SGTC_2103 5378138 10 µM 1.91440783669371 0.0176118846232073 no 94 0.0277840325060679 260 244142 SGTC_2384 9036245 200 µM 1.91301877853475 0.0176768784280252 no 95 0.0278728242420091 235 6462766 SGTC_1251 0490-5699 265 µM 1.90471212793843 0.0180698319341059 no 96 0.0284087508133674 294 3883818 SGTC_822 1487-0950 154 µM 1.89830330106508 0.0183780740315422 no 97 0.0288280696877599 253 1958375 SGTC_2002 4023503 131 µM 1.88982294631489 0.0187928247043242 no 98 0.0293908217945741 331 4736863 YCR052W RSC6 SGTC_1324 1418-0026 34.4 µM 1.88882642244964 0.0188420808831291 no 99 0.0294575455324658 263 1372513 SGTC_1736 st036774 51 µM 1.88693130010996 0.0189360560866258 no 100 0.0295847832626287 268 1272247 SGTC_1739 st037196 92.5 µM 1.88289869458704 0.0191373520606843 no 101 0.0298570490914127 264 612214 SGTC_882 0843-0131 351 µM 1.88197959958291 0.0191834843277238 no 102 0.0299193927823918 256 5425421 SGTC_608 k048-0125 159 µM 1.87575027837396 0.0194986517937245 no 103 0.030344789198849 254 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1138 3761-0006 1.03 µM 1.87082625646206 0.019750881017541 no 104 0.0306845835117903 205 12061087 SGTC_2608 thymoquinone 42.66 µM 1.86241001273087 0.020188409372589 no 105 0.0312726594367083 235 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2839 9003951 25.97 µM 1.85101014085727 0.0207941283603612 no 106 0.0320840471105277 215 2990634 SGTC_1746 st038117 42 µM 1.84966177774036 0.0208667794115725 no 107 0.032181156366903 284 2898218 SGTC_1215 3852-0577 11.2 µM 1.84882539730594 0.0209119522557791 no 108 0.0322415144085604 274 2884876 SGTC_2752 diclazuril 33.15 µM 1.84433909910843 0.0211556720623335 no 109 0.0325668683609048 431 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2490 carminic acid 95.39 µM 1.82673594530613 0.0221353076618745 no 110 0.0338697404632537 188 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_114 0364-0001 490.298 µM 1.82309148750892 0.0223428393570784 no 111 0.0341447678280775 317 4003655 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.81315022415231 0.0229173003967999 no 112 0.034904327303282 359 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_862 0452-0056 10.2 µM 1.80723546338344 0.0232649551215723 no 113 0.0353627868465209 256 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_15 0266-0086 27.098 µM 1.80320511232729 0.0235043833883112 no 114 0.035678003948363 374 1712902 YIL048W NEO1 SGTC_312 4092-0653 6.84 µM 1.80268775230539 0.0235352674344395 no 115 0.0357186333739587 402 1148278 SGTC_2331 7980721 200 µM 1.79772932272828 0.0238329982887773 no 116 0.0361099561466502 307 2981221 SGTC_2050 5263056 171 µM 1.78370757635532 0.0246921233311313 no 117 0.0372355971990943 342 763468 YGL055W OLE1 SGTC_2316 5844804 197.44 µM 1.77337937527706 0.0253414315615171 no 118 0.0380829321188703 386 776813 SGTC_2360 9040895 200 µM 1.76349638165686 0.0259760830071007 no 119 0.0389084035067506 280 4914414 SGTC_2814 7977482 42.97 µM 1.76273855017959 0.0260252923863866 no 120 0.0389722978577273 395 6456762 SGTC_739 1486-1183 203 µM 1.76253747828579 0.0260383619630339 no 121 0.0389892649820859 305 4346692 SGTC_1219 1469-0211 33.1 µM 1.76235535068916 0.0260502049073097 no 122 0.0390046387136367 259 6822282 SGTC_2918 7977171 22.06 µM 1.76088770791846 0.0261458036892996 no 123 0.0391287054087297 284 2236483 SGTC_3297 9117502 71.43 µM 1.75222919757063 0.0267157877624732 no 124 0.0398672024930529 247 7453720 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.75166275746089 0.0267534350329688 no 125 0.0399159071911437 299 521171 SGTC_1100 amiodarone 5.07 µM 1.74914951088072 0.0269210075393949 no 126 0.0401325894091982 323 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_56 0957-0365 83.25 µM 1.74376367433728 0.0272830640083639 no 127 0.0406001535571506 334 6752360 SGTC_1096 rimcazole 32.2 µM 1.74175599419313 0.0274190630576083 no 128 0.0407755749548707 264 18528119 A dopamine reuptake inhibitor. SGTC_2341 7987486 176.74 µM 1.74136025259702 0.0274459369434544 no 129 0.0408102254007851 338 1258686 SGTC_155 k072-0202 43.6 µM 1.74014375600297 0.0275286839365864 no 130 0.0409168893450384 264 5857737 SGTC_156 3474-0145 5.642 µM 1.72656129340463 0.0284667782929182 no 131 0.0421232412286213 332 2265471 SGTC_2843 9000894 45.46 µM 1.72619695051825 0.0284923040394969 no 132 0.042155993242778 186 2242070 SGTC_2616 abietic acid 100 µM 1.72396545517074 0.0286490576733736 no 133 0.042357039797688 329 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_537 1334-0398 209 µM 1.71840508871342 0.02904277355375 no 134 0.0428613764063211 324 5846986 SGTC_477 mead ethanolamide 10 µM 1.70535795598764 0.0299842848226102 no 135 0.0440638423260532 161 16061185 SGTC_2129 girgensonine 121.053 µM 1.70138491790275 0.0302759662589666 no 136 0.0444353657568693 363 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1678 st019265 80.2 µM 1.69976064026564 0.0303958882622334 no 137 0.0445879789012344 369 5367020 SGTC_1271 0832-2808 169 µM 1.69939428039918 0.0304229912954469 no 138 0.0446224594650479 327 3663794 SGTC_807 1315-0151 48 µM 1.6980756402999 0.0305207090985519 no 139 0.04474674326097 374 4011080 SGTC_1797 st048695 56.8 µM 1.69456518281777 0.030782119487037 no 140 0.0450789683128115 349 592262 YIL048W NEO1 SGTC_2840 9008771 71.43 µM 1.69162253502815 0.0310026728964365 no 141 0.0453589834873359 255 2992978 SGTC_2976 9009005 19.48 µM 1.68725014687895 0.0313328000014827 no 142 0.0457776312878087 322 2993148 SGTC_2130 NSC 7 2.4545 µM 1.67474716566585 0.032292882103344 no 143 0.0469919245501657 356 21448 SGTC_1322 1348-1070 12 µM 1.66609204502972 0.0329716129709149 no 144 0.0478475413667044 262 6758089 SGTC_352 k048-0007 5.11 µM 1.66063487296254 0.0334055741210278 no 145 0.0483934003439273 401 6811911 SGTC_1008 4106-0037 6 µM 1.65632130592153 0.0337519127493205 no 146 0.0488283840173066 306 2905394 SGTC_2770 toltrazuril 17.5 µM 1.6483082935688 0.0344031225263452 no 147 0.0496447118582545 360 68591 Kills coccidiodes. SGTC_3336 9143619 71.43 µM 1.64221690628314 0.0349050413763399 no 148 0.050272530116214 374 45595730 SGTC_1445 4239-0156 97.7 µM 1.64077637933919 0.0350246127961198 no 149 0.0504219215984692 397 4008346 SGTC_998 3996-0085 177 µM 1.64027165239061 0.0350665872666391 no 150 0.0504743484843252 396 715391 SGTC_1590 st077108 57.8 µM 1.62927233132458 0.0359916191164581 no 151 0.0516276903688486 311 5489485 SGTC_1115 galangin 695.678 nM 1.62505038190544 0.0363519479364075 no 152 0.0520759120339898 390 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2024 5144227 134 µM 1.62482652167007 0.0363711357695453 no 153 0.0520997641012713 404 3475211 SGTC_1086 cerivastatin 2.18 µM 1.62425941429204 0.0364197816006117 no 154 0.0521602276223845 308 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_27 0485-0001 32.618 µM 1.62154010318785 0.0366537813591049 no 155 0.0524509282636282 245 2054479 SGTC_2362 9071156 126 µM 1.61828659114651 0.0369353641590516 no 156 0.0528004245293288 361 653133 SGTC_3308 9128332 17.569 µM 1.61430032791945 0.0372827728141774 no 157 0.053231149512861 469 17332805 YDL196W YDL196W SGTC_3287 9117173 37.0625 µM 1.61419939504468 0.0372916037963848 no 158 0.0532420915922327 271 2789709 SGTC_2970 9090938 41.86 µM 1.61080945515083 0.0375891958110425 no 159 0.0536106298189672 459 17217104 SGTC_871 0574-0004 149 µM 1.60951931188574 0.0377029615599533 no 160 0.0537514178531579 412 9551173 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.6063873322205 0.037980311409332 no 161 0.0540944162373647 256 77254 SGTC_1587 estradiol valerate 56.1 µM 1.59176105509734 0.0392976464874368 no 162 0.0557192019225314 380 13791 A steroid. SGTC_80 0159-0065 512.242 µM 1.58617882214625 0.0398101205776384 no 163 0.0563493752216087 233 1548079 SGTC_2396 5342950 42.78 µM 1.58600061264478 0.0398265700788245 no 164 0.0563695852918243 432 1886677 SGTC_996 3970-0799 1.8 µM 1.58508236269666 0.0399114160890906 no 165 0.0564738111485429 525 6615648 YGL040C HEM2 SGTC_853 0419-0306 21 µM 1.58475430636965 0.0399417639876176 no 166 0.0565110839446 340 762713 SGTC_2393 9031399 185.94 µM 1.58001135861433 0.0403826247824288 no 167 0.0570521326335594 387 1526623 YDL150W RPC53 SGTC_887 0885-0007 9.62 µM 1.57616552408162 0.0407429920516904 no 168 0.0574938307803255 412 5719458 SGTC_1560 lithocholic acid 53.1 µM 1.57436417974486 0.0409126790211823 no 169 0.0577016400131822 264 9903 A bile acid which acts as a detergent. SGTC_2493 resveratrol 26.09 µM 1.56875528511413 0.0414447124796178 no 170 0.058352485548242 315 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_607 4491-0986 66.8 µM 1.56853287802532 0.0414659239978232 no 171 0.0583784116118204 408 698981 YDR232W HEM1 SGTC_973 1325-0077 65.9 µM 1.56808142341681 0.0415090074002392 no 172 0.0584310656351745 409 2835149 SGTC_1359 1582-0056 520 nM 1.56799228157248 0.0415175187079657 no 173 0.0584414668284692 434 3661189 SGTC_1140 3229-1848 2.98 µM 1.55770507527027 0.042509283733767 no 174 0.0596515884256812 340 2849525 SGTC_2605 digitonin 300 nM 1.55370507984268 0.0429000502310566 no 175 0.060127390409089 458 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1200 1643-0193 18.4 µM 1.54963373546888 0.0433007627072421 no 176 0.0606147255206665 420 5403974 SGTC_917 harmaline 728.087 nM 1.54634721721733 0.043626430445503 no 177 0.061010367155483 409 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_164 4100-3994 89.624 µM 1.54493295900516 0.0437671791091776 no 178 0.0611812401199387 460 4615967 SGTC_1058 3448-5425 97.3 µM 1.54481096488946 0.0437793372528099 no 179 0.0611959971500929 376 7279705 SGTC_2576 guaiol 23.12 µM 1.54216413546074 0.0440437963484367 no 180 0.0615168564542427 421 227829 SGTC_713 1488-1073 324 µM 1.54114450844343 0.0441460158899815 no 181 0.0616408097282833 352 3312542 SGTC_309 k408-0051 1.48 µM 1.53616471279579 0.0446480010449538 no 182 0.0622489940574042 493 3640463 SGTC_2474 5321570 43.32 µM 1.53103572501667 0.0451698212043331 no 183 0.0628802817801566 372 2841384 SGTC_2891 9063876 19.48 µM 1.52744153398939 0.0455384079160015 no 184 0.0633256275591858 299 6472478 SGTC_196 k015-0023 18.111 µM 1.52671340601335 0.0456133717196447 no 185 0.0634161461742196 424 5211998 SGTC_2398 5228213 48.84 µM 1.52503257497088 0.0457867991366963 no 186 0.0636254864516782 499 80771 YMR134W ERG29 SGTC_2973 9094665 17.96 µM 1.51556157422285 0.0467739417705555 no 187 0.064815124794646 466 25237061 YIL048W NEO1 SGTC_738 1315-0003 72.4 µM 1.51047035894026 0.0473116023303421 no 188 0.0654617236153915 435 6251474 SGTC_1674 st016616 23.6 µM 1.50677384243207 0.047705069818863 no 189 0.0659343182646611 422 625830 SGTC_1270 0831-1170 17.3 µM 1.50218996496094 0.0481966252911606 no 190 0.0665240278585832 447 6764716 SGTC_1644 st010134 20.9 µM 1.50190217845725 0.0482276209883946 no 191 0.0665611869762306 374 3818134 SGTC_2586 curcumin 80 µM 1.50110633453621 0.0483134194308921 no 192 0.0666640303380106 502 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_637 1181-0519 7.26 µM 1.49974217681884 0.0484607706932085 no 193 0.0668406003648979 549 6252091 YGR060W ERG25 SGTC_2346 9031566 143.75 µM 1.49846961521761 0.0485985518757778 no 194 0.0670056406281905 393 4771086 SGTC_2809 7964133 12.99 µM 1.49811889127828 0.0486365800170129 no 195 0.0670511818575264 457 1253665 SGTC_2094 5332512 191.667 µM 1.49809023864813 0.0486396878026154 no 196 0.0670549034366157 434 755774 SGTC_1041 0206-0046 107 µM 1.46742609088771 0.0520576990032178 no 197 0.0711300906229515 436 50494 SGTC_365 0121-0052 13.6 µM 1.46574577310712 0.0522503768253767 no 198 0.0713587795456358 529 3101739 SGTC_606 k015-0008 38.6 µM 1.46260726497628 0.0526117781075335 no 199 0.0717874370942703 479 1970475 SGTC_2754 granisetron 64.02 µM 1.46068891027772 0.0528336529571849 no 200 0.0720504168999744 467 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1230 0170-0365 3.77 µM 1.46035175329422 0.0528727247555253 no 201 0.072096712656291 599 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2372 9071633 200 µM 1.45791588956059 0.0531556888151686 no 202 0.0724318641602468 477 21321366 SGTC_466 geldanamycin 89.2 µM 1.45603107043319 0.0533754632021791 no 203 0.0726920153377377 313 5288382 HSP90 inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.45321528239923 0.0537051315773099 no 204 0.0730819951542245 455 5282309 SGTC_2365 9042475 200 µM 1.44484079674687 0.0546951414329843 no 205 0.0742513044297507 477 6464479 SGTC_67 0335-0847 266 µM 1.44443744978165 0.0547431858554553 no 206 0.0743079813752644 608 4552207 YOR254C SEC63 SGTC_3284 9108171 64.8615 µM 1.44351009669883 0.0548537734722009 no 207 0.0744384151673181 401 8687505 SGTC_1687 st020778 55.3625 µM 1.44055476396453 0.0552073776493169 no 208 0.0748552539849026 623 4259299 SGTC_2533 agelasine 13.65 µM 1.43679588492334 0.0556597243311787 no 209 0.0753880000136006 498 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_491 tetrandrine 80.3 µM 1.42644006382808 0.0569210916963253 no 210 0.076870678040874 395 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1620 st003704 16.5 µM 1.41431708706688 0.058426182277782 no 211 0.0786344110775663 453 2834414 SGTC_2967 9089538 49.85 µM 1.41176824599938 0.058746566995697 no 212 0.0790091055671109 514 728216 SGTC_884 0851-0618 334 µM 1.40776554610515 0.0592524802033889 no 213 0.0796002528295219 504 9642473 SGTC_641 4092-0595 30 µM 1.40655694564625 0.059405908496058 no 214 0.0797794037289238 503 786260 SGTC_218 alverine citrate 93.75 µM 1.40045225063947 0.0601856462588013 no 215 0.0806889663261734 445 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2301 7769476 200 µM 1.40021310309112 0.0602163542988551 no 216 0.080724756607481 416 977820 SGTC_2076 5212012 200 µM 1.39587571683997 0.0607754328881564 no 217 0.0813759621515661 377 604802 SGTC_801 0866-0028 10.1 µM 1.39515093057651 0.0608692506582647 no 218 0.0814851652647125 514 6849771 SGTC_718 1130-0073 349 µM 1.39271222809875 0.0611857528291384 no 219 0.0818534146853235 512 6740020 SGTC_542 3381-0244 89.3 µM 1.39266998162488 0.0611912470148782 no 220 0.0818598050293279 558 1112843 SGTC_3048 9093155 49.47 µM 1.3902804173709 0.0615026397242069 no 221 0.0822218709809081 408 25236002 SGTC_3315 9136395 68.55 µM 1.38827964484029 0.061764318363155 no 222 0.0825259540050308 505 16876844 SGTC_886 0866-0150 153 µM 1.38690992340162 0.0619439632079837 no 223 0.0827346157645311 508 271463 SGTC_2650 prasterone 100 µM 1.37981642352104 0.0628808378576998 no 224 0.0838215872793777 389 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2275 7947463 200 µM 1.37715573571037 0.0632350820774336 no 225 0.0842320519004754 457 1225414 SGTC_519 k048-0011 62.8 µM 1.3730580596394 0.0637836839278817 no 226 0.084867148987477 494 6836379 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.37165681250054 0.0639721317216337 no 227 0.0850851494109731 570 688788 SGTC_1756 st041558 35.5 µM 1.37139058595624 0.0640079842948334 no 228 0.0851266152717683 541 3955792 SGTC_408 cantharidin 100 µM 1.3697166242851 0.0642337738090527 no 229 0.0853876886032309 533 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1946 st076057 65.1 µM 1.3678130588737 0.0644912847488985 no 230 0.0856852995071766 360 953009 SGTC_2994 9053520 71.4286 µM 1.36198444653959 0.0652847581797496 no 231 0.0866013968378026 510 4647384 SGTC_1499 4480-0877 67.3 µM 1.36115003043673 0.0653989678375353 no 232 0.0867331408873043 446 2861909 SGTC_899 1083-0020 478 µM 1.35800074244728 0.0658314193616338 no 233 0.0872317242850948 522 767123 SGTC_846 0335-0850 148 µM 1.35759678401114 0.0658870498242979 no 234 0.0872958320006163 463 6819598 SGTC_1340 1486-1359 257 µM 1.35711743398872 0.0659531099711205 no 235 0.0873719498950184 505 4309068 SGTC_1793 st048256 72.231 µM 1.3566179930293 0.0660219934720438 no 236 0.0874513108003867 473 672022 SGTC_2324 6149169 200 µM 1.351903451943 0.0666749781014885 no 237 0.0882031015650191 472 2888231 SGTC_622 1348-1566 26.3 µM 1.35070246299858 0.0668421165040374 no 238 0.088395381497472 569 7340407 SGTC_2359 9039622 200 µM 1.3492271871474 0.0670478701153266 no 239 0.0886320024006794 536 6463596 SGTC_290 2043-6722 48.1 µM 1.34560287231293 0.0675554253866344 no 240 0.0892153124256282 517 773758 YLR208W SEC13 SGTC_737 1950-0117 57.9 µM 1.34386016889775 0.0678005311527497 no 241 0.0894968041394085 498 5393513 SGTC_418 lividomycin a 100 µM 1.34298166156552 0.0679243505728069 no 242 0.0896389559917401 538 72394 An antibiotic. SGTC_2886 9058944 51.95 µM 1.33929481510935 0.068445890470964 no 243 0.0902373580011797 321 4949929 SGTC_2697 mebhydrolin 72.4 µM 1.33894929774543 0.0684949251283522 no 244 0.0902935896884837 582 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2935 9038016 29.96 µM 1.33777389680802 0.0686619369739193 no 245 0.0904850767459908 541 6463195 SGTC_2215 7188065 200 µM 1.33614978184904 0.0688932228182678 no 246 0.0907501606458702 444 940217 SGTC_2638 epoxomicin 18 µM 1.33599210254033 0.0689157094512353 no 247 0.0907759273202178 564 9915668 A protesome inhibitor. SGTC_2847 9005661 71.43 µM 1.33040652047904 0.0697159243385127 no 248 0.0916921836852805 380 2991449 SGTC_2436 5633522 8.09 µM 1.32585517217061 0.0703732433423619 no 249 0.0924438369648664 551 5724242 SGTC_2899 9053889 58.44 µM 1.32409277537642 0.0706290499121399 no 250 0.0927361173385608 483 6470052 SGTC_829 1635-0120 117 µM 1.32381397506626 0.0706695823202118 no 251 0.092782416830635 558 285054 SGTC_2220 6782180 200 µM 1.32353509934394 0.0707101435723832 no 252 0.0928287459444644 445 833803 SGTC_63 0099-0242 26.702 µM 1.32230234829736 0.0708896561645398 no 253 0.0930337455620004 597 3898502 YLR359W ADE13 SGTC_1606 st000094 49.2 µM 1.31837292100154 0.0714641942981986 no 254 0.0936894205219359 551 1242210 SGTC_2807 7945238 51.95 µM 1.31702902042945 0.0716615096115574 no 255 0.093914448589092 553 17148797 SGTC_2027 5150920 200 µM 1.31440301375889 0.072048273291059 no 256 0.0943553084076225 527 786715 SGTC_1751 st044839 27.194 µM 1.30286650550474 0.073766374941838 no 257 0.0963101703800986 507 5291326 SGTC_201 4262-0159 12.803 µM 1.30281924441379 0.0737734772600925 no 258 0.0963182395373264 469 1341029 SGTC_2123 5259487 200 µM 1.29953187072826 0.0742687820026423 no 259 0.0968807316522981 578 2173474 SGTC_3018 9082602 49.47 µM 1.29824620722438 0.0744631807606312 no 260 0.097101372301375 563 17332089 SGTC_2380 9035439 200 µM 1.29490196544498 0.0749706661397279 no 261 0.0976770252029078 603 6462575 SGTC_183 3914-0051 30.55 µM 1.29358013269355 0.075171978807556 no 262 0.0979052442886656 545 1596232 SGTC_808 0711-0032 135 µM 1.29186841371301 0.0754332825551891 no 263 0.0982013590012642 531 4252555 SGTC_588 3970-1144 52.9 µM 1.28937292386216 0.0758154729427504 no 264 0.0986342349117648 589 1888707 SGTC_2158 5657123 3.6195 µM 1.28848150893531 0.0759523522420049 no 265 0.0987892007679347 537 2858827 SGTC_1642 st009582 77.7 µM 1.28662915183442 0.0762373886175045 no 266 0.0991117889114473 513 6739311 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.28519462503698 0.0764586890428724 no 267 0.0993621407158706 607 1273210 SGTC_2851 9015922 71.43 µM 1.28444813164799 0.0765740416397765 no 268 0.0994926005318373 565 2996893 SGTC_2801 7907800 81.82 µM 1.28307237386133 0.0767869786209688 no 269 0.0997333607036942 589 6620925 SGTC_186 3455-3465 67.277 µM 1.28209514567349 0.0769385052742425 no 270 0.0999046358192441 438 755278 SGTC_103 0844-0104 51.839 µM 1.27952161441137 0.0773386382277619 no 271 0.100356716588572 665 5375804 SGTC_2955 9076254 12.21 µM 1.27760346311269 0.077637899313521 no 272 0.10069463943933 522 16459619 SGTC_1375 2910-0797 186 µM 1.27660691474487 0.0777937227965152 no 273 0.100870529709786 551 742508 SGTC_1019 4262-0212 3.4 µM 1.27462417638973 0.0781044558992513 no 274 0.101221148033623 649 4677213 SGTC_2143 5623677 140.463 µM 1.27238689227582 0.0784562107973586 no 275 0.101617844485579 517 5375313 SGTC_940 3232-1287 54.8 µM 1.27083561323462 0.078700813381777 no 276 0.101893568108312 575 1585493 YIL048W NEO1 SGTC_2257 7960413 200 µM 1.26850263118963 0.0790697608135267 no 277 0.102309255843381 628 2974689 YIL048W NEO1 SGTC_1924 st058459 75.1 µM 1.26178269818964 0.0801397988617751 no 278 0.103513494804719 543 688683 SGTC_2116 5511452 16.8835 µM 1.26130923513128 0.0802156007990402 no 279 0.103598727597423 585 870744 SGTC_1641 st009299 47.1 µM 1.2608762065341 0.0802849765712689 no 280 0.103676725958626 495 4046054 SGTC_485 niflumic acid 177 µM 1.25609899160547 0.081053349095388 no 281 0.104540040853219 541 4488 A COX2 inhibitor. SGTC_564 3555-0129 330 µM 1.25591871562659 0.0810824531769187 no 282 0.104572721113684 476 563260 SGTC_1078 idebenone 36.1 µM 1.25498121426443 0.0812339322625646 no 283 0.104742789799807 634 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3342 9147791 14.508 µM 1.25457281192181 0.0812999876005469 no 284 0.104816939173115 577 1838168 SGTC_3024 9090631 49.47 µM 1.25361979300375 0.0814542872720612 no 285 0.104990116741518 537 25236383 SGTC_2639 lactacystin 53 µM 1.24854700046943 0.0822793224306384 no 286 0.10591540376099 626 3870 A proteasome inhibitor. SGTC_1455 4262-0120 131 µM 1.24847785374039 0.0822906117192702 no 287 0.105928056839945 603 1529587 SGTC_81 0411-0046 9.971 µM 1.24736253539555 0.0824728661294133 no 288 0.10613229857006 533 12925265 SGTC_1398 3558-0053 112 µM 1.24729359042078 0.0824841424078855 no 289 0.106144933390609 507 4532369 SGTC_691 1548-0686 185 µM 1.24481797872959 0.0828898099860769 no 290 0.106599332947023 604 46495133 SGTC_934 2950-0684 338 µM 1.23690885106183 0.0841959022045664 no 291 0.108060461852499 627 1121253 SGTC_3207 9114163 49.47 µM 1.23596953016986 0.0843520397180813 no 292 0.108234944921126 662 849233 SGTC_2250 alverine citrate 130 µM 1.23184530562955 0.0850401561302576 no 293 0.109003437856364 704 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2239 6685329 187.64 µM 1.23147686156025 0.0851018342166478 no 294 0.109072282737754 598 805680 SGTC_1186 1319-0216 26 µM 1.2279668495049 0.0856910973398974 no 295 0.109729706337881 639 4565136 SGTC_3343 9148379 18.9835 µM 1.22721711817933 0.085817357706304 no 296 0.109870498580766 596 1955036 SGTC_2866 9034245 58.44 µM 1.22289132795457 0.0865485738638125 no 297 0.110685372210847 547 6462273 SGTC_933 2914-0560 114 µM 1.22273899287579 0.0865744086767149 no 298 0.110714147170984 662 463887 SGTC_2799 7812892 81.82 µM 1.22062638656152 0.086933284363619 no 299 0.111113755522181 637 20205235 SGTC_3346 9158254 43.5805 µM 1.22048752544788 0.0869569120442324 no 300 0.111140057814004 603 17639500 SGTC_1618 st003135 44.5 µM 1.21907547650628 0.0871974493431217 no 301 0.111407773389344 593 1270615 SGTC_1698 5-fluorocytosine 1.055 µM 1.2177449777404 0.0874245491626991 no 302 0.111660449613974 598 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_626 0214-0009 33 µM 1.2141290087255 0.0880439806880143 no 303 0.112349232078177 637 3437874 SGTC_345 1362-0200 395 µM 1.21343180593864 0.0881637900013974 no 304 0.112482386077581 577 1419823 SGTC_1801 st050089 28.441 µM 1.21282230722625 0.0882686275236266 no 305 0.112598882397372 713 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2965 9082772 38.63 µM 1.21257482469764 0.0883112225514272 no 306 0.112646209472761 642 16459634 SGTC_865 0488-0499 301 µM 1.21139797111466 0.0885139843093456 no 307 0.112871458297871 658 9634651 SGTC_2284 7945075 39.21 µM 1.21057818427419 0.0886554313442066 no 308 0.11302855472047 680 1245402 SGTC_534 k292-0788 63.4 µM 1.2020561460403 0.0901358185418619 no 309 0.114670887790101 685 4146317 SGTC_226 1,3-diallylurea 8.28947 mM 1.19973812163688 0.0905416482660195 no 310 0.115120531338583 561 74537 YKL182W FAS1 SGTC_1685 st024049 53.0905 µM 1.19926694100385 0.0906243061718802 no 311 0.115212082672342 587 1941139 SGTC_2690 usnic acid 100 µM 1.19891912739952 0.0906853580679346 no 312 0.115279696744757 693 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2272 7805186 180 µM 1.19489244108965 0.0913943880550907 no 313 0.11606452828156 607 2956062 YPR165W RHO1 SGTC_2373 9071805 200 µM 1.18896035805998 0.0924463995186878 no 314 0.117227633375185 633 10149009 SGTC_1572 epiandrosterone 68.9 µM 1.18792252725349 0.0926313684470257 no 315 0.117431966781597 672 441302 A steroid. SGTC_478 N-arachidonylglycine 10 µM 1.18543982447395 0.0930749622774509 no 316 0.117921796854635 493 5283389 SGTC_1403 3909-7815 62.9 µM 1.18488004650253 0.093175196468099 no 317 0.118032438843284 577 6615483 SGTC_2692 st077426 47.7 µM 1.18421274053437 0.0932947888858581 no 318 0.118164430017545 651 25238571 SGTC_1700 st030840 7.9285 µM 1.18327498703094 0.0934630416503374 no 319 0.1183500912791 685 5499307 SGTC_1456 k015-0012 13 µM 1.17981022434142 0.0940866370412964 no 320 0.119037851060328 716 2989616 SGTC_1291 0993-0025 5.79 µM 1.17641683220802 0.0947003573670374 no 321 0.119714174376173 651 4353356 SGTC_539 4859-0462 2.54 µM 1.17589695769201 0.0947946405995314 no 322 0.119818027374065 643 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3160 9100216 49.47 µM 1.1732325306797 0.0952789407720462 no 323 0.120351285032288 653 17191039 SGTC_130 0136-0219 337.655 µM 1.16883248331065 0.0960827006392967 no 324 0.121235565059777 677 234244 SGTC_326 k292-0812 17.5 µM 1.16655235094125 0.0965011699878672 no 325 0.121695597740518 627 3579357 SGTC_648 0375-0473 33.3 µM 1.16612066881641 0.0965805465030352 no 326 0.121782830551922 681 1713139 SGTC_939 1165-0479 45.3 µM 1.15715542980161 0.0982399067397654 no 327 0.123604431808721 666 1377347 SGTC_872 0588-0139 234 µM 1.15641419894841 0.09837802881602 no 328 0.123755888245973 669 2047100 SGTC_2999 9069765 71.4286 µM 1.15294294063897 0.0990267610063211 no 329 0.124466902705697 683 2097066 SGTC_1397 3532-0190 20.1 µM 1.15253367506575 0.0991034530583688 no 330 0.124550920022877 567 5322280 SGTC_2221 6807166 181.081 µM 1.14996770544012 0.0995852788619617 no 331 0.12507858638181 581 674925 SGTC_2523 spermine 47.74 µM 1.14915100706099 0.0997389932248492 no 332 0.125246859432989 643 1103 A DNA binding polyamine. SGTC_1796 st049173 110.4 µM 1.13705315724436 0.102036316349033 no 333 0.127758032214327 623 94134 SGTC_3303 9125618 40.5795 µM 1.13674788123081 0.102094780728081 no 334 0.127821848371303 754 22695467 SGTC_3322 9139058 2.11 µM 1.13553180195198 0.102327917856162 no 335 0.128076282473425 693 4908926 YPR165W RHO1 SGTC_1117 retinoic acid 1.10837 µM 1.1319952942173 0.103008108940359 no 336 0.128818206410791 739 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3226 9131256 49.47 µM 1.13150750755278 0.103102184097074 no 337 0.128920772667869 558 17178073 SGTC_2953 9074162 66.49 µM 1.13016122326695 0.10336215394006 no 338 0.129204147921158 622 16451992 SGTC_18 0111-0177 500 nM 1.1280185850331 0.10377688191552 no 339 0.129656035162122 786 721752 SGTC_1143 3454-2408 5.08 µM 1.12590650343544 0.104186875490964 no 340 0.130102548159011 637 X1143 SGTC_2640 pentamidine 10.38 µM 1.11987125280238 0.105364896205018 no 341 0.131384315076106 745 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_634 1611-4317 11.2 µM 1.11771072360992 0.105788943268567 no 342 0.131845280641746 752 2843522 SGTC_2482 5981709 142.65 µM 1.11581817937512 0.106161405353634 no 343 0.132249985251514 714 877755 SGTC_855 0428-0020 25 µM 1.11518385310565 0.10628645562458 no 344 0.132385821982209 635 6812414 SGTC_2948 9070189 9.45 µM 1.11391433571724 0.106537046104995 no 345 0.132657969357162 622 6473636 YDL196W YDL196W SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.10988409998586 0.107335401388815 no 346 0.133524486453043 735 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_826 1683-5028 118 µM 1.10791591110197 0.107726846420504 no 347 0.133949066664614 689 722377 SGTC_3168 9103419 49.47 µM 1.10721619864699 0.107866256863773 no 348 0.134100232829351 600 16649256 SGTC_1040 k898-0338 155 µM 1.10465773501186 0.10837711025939 no 349 0.134653961861324 766 20969351 SGTC_1247 0448-0043 5.84 µM 1.09997144216106 0.10931734179645 no 350 0.135672282431486 736 3089013 YGL099W LSG1 SGTC_500 h-89 112 µM 1.0985081519171 0.109612125182547 no 351 0.135991329994047 759 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1935 st074532 41.6 µM 1.09570911333284 0.110177587480267 no 352 0.136603046611453 796 2829742 SGTC_2269 7935389 174.42 µM 1.09364535765321 0.110595845798841 no 353 0.137055273999557 682 97605 SGTC_1351 1496-0003 46.5 µM 1.09190854821585 0.110948723322054 no 354 0.137436650016319 747 3891978 SGTC_46 0329-0187a 2.197 µM 1.09169866628803 0.11099142079387 no 355 0.137482785807627 801 46494817 SGTC_1139 k015-0024 46.9 µM 1.09093502254079 0.111146872486284 no 356 0.137650737539018 725 2766652 SGTC_1988 st071872 53.4 µM 1.09084389666476 0.111165432997976 no 357 0.137670788625964 733 16414116 SGTC_134 0269-0018 6.916 µM 1.09069924766325 0.111194899653126 no 358 0.137702620887342 718 4378915 SGTC_3177 9107506 49.47 µM 1.08847667559481 0.111648366280408 no 359 0.138192363971653 678 8897194 SGTC_2375 9072683 200 µM 1.0882433408328 0.111696049701887 no 360 0.138243848012993 797 16798029 SGTC_856 0433-0016 11.3 µM 1.08475125730414 0.112411419977911 no 361 0.139015919545743 739 3911780 SGTC_2125 5246583 200 µM 1.08401561340299 0.112562536704839 no 362 0.139178938083843 818 835267 SGTC_3354 9151612 71.43 µM 1.0824827750338 0.112877879977973 no 363 0.139519032581875 761 27261949 SGTC_2176 5809774 33.9695 µM 1.0824030234973 0.112894304110281 no 364 0.139536742700671 763 2870539 SGTC_2363 9053361 176 µM 1.07953573751092 0.113485930205739 no 365 0.140174485671876 727 6469797 YMR079W SEC14 SGTC_254 nsc-64875 3.808 µM 1.0779110121308 0.113822150247253 no 366 0.140536735283373 729 56993 SGTC_828 2074-0507 139 µM 1.07684786501771 0.114042541385944 no 367 0.140774118791265 745 X828 SGTC_1106 tegaserod maleate 11.7 µM 1.07554531295662 0.114312975517708 no 368 0.14106532821335 754 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_426 0988-0037 14.6 µM 1.07375854927578 0.114684683369221 no 369 0.141465456160474 795 5383008 SGTC_2453 5731132 22.18 µM 1.07292026385903 0.114859371454142 no 370 0.141653446648451 781 1362040 SGTC_1523 st012844 44.7 µM 1.07070790884818 0.115321306988982 no 371 0.142150392774634 729 4274103 SGTC_2126 5251174 33.877 µM 1.07054909345728 0.115354518066514 no 372 0.142186111720244 827 790722 SGTC_2151 5563267 85.4165 µM 1.06881341482353 0.115717922003447 no 373 0.142576876679276 762 5310824 SGTC_2415 st077333 57.7 µM 1.06862824583143 0.115756739306885 no 374 0.142618607845427 826 2766255 SGTC_2594 a-mangostin 100 µM 1.06748540220044 0.115996520319837 no 375 0.142876351017861 756 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2670 beta-carotene 100 µM 1.06405192044442 0.116719022439097 no 376 0.143652589836121 669 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2212 7123476 200 µM 1.0602252833457 0.117528008602122 no 377 0.144521060662687 654 1085715 SGTC_1177 0983-0204 23.6 µM 1.06020126785691 0.11753309820033 no 378 0.144526522222125 786 766818 SGTC_2917 7979103 53.79 µM 1.05938895610675 0.117705343193286 no 379 0.144711338608427 793 2980565 SGTC_435 c-PAF 6.7 µM 1.05884733729256 0.117820288879964 no 380 0.144834655611799 751 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1799 st045822 46.1415 µM 1.05546306892042 0.118540318040402 no 381 0.145606795692266 727 3674992 SGTC_567 1080-0542 68.4 µM 1.05475307609546 0.118691768272785 no 382 0.145769135190604 691 5950415 SGTC_3202 9113761 49.47 µM 1.05273326279617 0.119123366857784 no 383 0.146231629619851 814 4798415 SGTC_848 0368-0089 85.6 µM 1.05257246129296 0.119157774864156 no 384 0.146268492059906 774 762535 SGTC_716 1683-5115 658 µM 1.05244450191014 0.119185160387021 no 385 0.146297830168536 841 723597 SGTC_2463 5473429 200 µM 1.05061120797632 0.119578004888695 no 386 0.146718595663086 718 5399405 SGTC_1531 st059297 52.4 µM 1.04869000251842 0.119990666544975 no 387 0.147160408522118 761 7566702 SGTC_2915 7971052 15.16 µM 1.04770087509215 0.120203515273942 no 388 0.147388222133053 589 5741558 SGTC_1395 3486-0190 4.35 µM 1.04738037522221 0.120272540153094 no 389 0.147462089611585 803 6748079 SGTC_1705 st027868 56.3335 µM 1.04672071176155 0.120414697321547 no 390 0.147614204160013 739 292948 SGTC_1055 3448-0672 86 µM 1.04528552058262 0.120724389066122 no 391 0.147945513851045 739 748378 SGTC_282 k297-0036 65.7 µM 1.04515211291516 0.120753204803235 no 392 0.147976335887038 740 5061378 SGTC_2641 levomentholum 100 µM 1.04383378772639 0.121038220217761 no 393 0.14828114817119 724 16666 SGTC_1198 1612-1005 86.7 µM 1.04157195766325 0.121528318669001 no 394 0.14880508775105 783 6998509 SGTC_1248 0469-0687 58.6 µM 1.03960091368398 0.121956544973467 no 395 0.149262676125943 772 4017482 SGTC_1093 fluphenazine 7.97 µM 1.03906242891703 0.122073719534915 no 396 0.149387851470969 782 6602611 An atypical antipsychotic. SGTC_1276 0871-0068 94.2 µM 1.03685256691805 0.122555414492643 no 397 0.14990228633537 751 3414906 SGTC_1103 duloxetine 36.1 µM 1.03672855622375 0.122582485202829 no 398 0.149931189813511 840 60835 A selective serotonin reuptake inhibitor. SGTC_953 1188-0045 9.7 µM 1.03605266647489 0.122730101182467 no 399 0.1500887864268 774 6144426 SGTC_2625 euphol 100 µM 1.03249878954749 0.123508327862702 no 400 0.150919257204057 807 6708538 A triterpene alcohol. SGTC_449 xestospongin c 11.1929 µM 1.03241735612185 0.123526200539575 no 401 0.150938322361545 797 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3039 9090270 49.47 µM 1.02929666003134 0.124212483418504 no 402 0.151670146157097 721 17173750 SGTC_803 4488-1585 147 µM 1.0278565532738 0.124530079930025 no 403 0.152008654615836 783 747204 SGTC_3183 9108214 49.47 µM 1.02759580039227 0.124587646181449 no 404 0.152070000253593 681 4974831 SGTC_1871 st057448 67.3 µM 1.02680526380586 0.124762286132394 no 405 0.15225608513846 809 691747 SGTC_224 benfluorex 43.875 µM 1.02631566232105 0.124870531298342 no 406 0.152371408501964 722 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1973 st070275 50.2 µM 1.02599850341907 0.124940686435486 no 407 0.152446144748614 753 17118334 SGTC_2297 7971671 152.32 µM 1.02312531901927 0.125577485799128 no 408 0.15312429859181 753 909016 SGTC_2118 5526350 200 µM 1.02132062108335 0.125978626884016 no 409 0.153551279833111 808 743594 SGTC_1171 0368-0077 21.4 µM 1.01975924031778 0.126326404602788 no 410 0.153921329196328 740 3239779 SGTC_3230 9131665 49.47 µM 1.0186166547002 0.126581324576103 no 411 0.154192497179103 660 15943720 SGTC_2102 5377816 72.7585 µM 1.01464879008428 0.127469368541264 no 412 0.155136636547753 822 1379702 SGTC_1411 3909-8223 150 µM 1.01244441276179 0.127964595872708 no 413 0.155662806082528 840 X1411 SGTC_1846 st056244 14.8 µM 1.01110433641471 0.128266305005238 no 414 0.155983247553812 816 5393182 SGTC_180 1486-1293 102.781 µM 1.0082678916991 0.128906539673056 no 415 0.156662936414117 809 4140536 SGTC_2483 5729050 27.16 µM 1.00820616392966 0.128920497298124 no 416 0.156677749699162 888 2865180 SGTC_1553 gossypol 38.6 µM 1.00523505989903 0.129593550586572 no 417 0.15739183838661 705 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1012 4112-3522 18 µM 1.00376414855785 0.129927659878852 no 418 0.157746154392809 814 3112398 SGTC_3150 9097574 49.47 µM 1.00091869563417 0.130575680040496 no 419 0.158433058595077 788 17217476 SGTC_660 4031-1742 102 µM 0.999081718702916 0.130995216228279 no 420 0.158877553141973 823 6738706 SGTC_2588 indole-3-carbinol 100 µM 0.991688149840874 0.132693202166774 no 421 0.160674836738098 860 3712 Induces cell cycle arrest. SGTC_2150 5556613 200 µM 0.991545661828101 0.132726073772224 no 422 0.160709603690713 845 743190 SGTC_893 0958-0369 48.9 µM 0.991257220413506 0.132792633606371 no 423 0.160779998185027 830 6819948 SGTC_945 3381-0768 11.3 µM 0.991240465778921 0.132796500559442 no 424 0.160784087793526 858 1126236 YIL048W NEO1 SGTC_1453 4237-0541 195 µM 0.991210031272739 0.132803525011698 no 425 0.160791516670922 840 739892 SGTC_2048 5246248 200 µM 0.988880996470068 0.133341838275199 no 426 0.161360684653918 802 677046 SGTC_2602 kawain 100 µM 0.987040604075028 0.133768271287723 no 427 0.161811366783262 869 5369129 SGTC_1903 st060211 78.3 µM 0.98561876349985 0.134098363888458 no 428 0.162160113470081 863 688960 SGTC_3261 9137475 49.47 µM 0.98527697900644 0.134177795473826 no 429 0.162244018714156 621 17027690 SGTC_1381 2324-0066 62.1 µM 0.984912145792883 0.134262619295652 no 430 0.162333613409832 769 10885928 SGTC_2946 9065502 71.43 µM 0.983667271406744 0.134552330121518 no 431 0.162639568479094 658 16489101 SGTC_2205 7238770 200 µM 0.983447883319057 0.134603431204311 no 432 0.162693526748777 824 279867 SGTC_2025 5147754 141 µM 0.981664164741981 0.135019399187526 no 433 0.16313266261017 821 315777 YLR208W SEC13 SGTC_1882 5615643 20 µM 0.979324182047538 0.135566425129594 no 434 0.163709912847133 777 2253075 SGTC_1306 1185-0270 9.02 µM 0.979129340959316 0.135612042196992 no 435 0.163758037916579 860 1548076 SGTC_1275 0867-0008 21.1 µM 0.977950858258085 0.135888177988883 no 436 0.164049314753539 823 3422836 SGTC_2441 5730946 39.09 µM 0.97737508241545 0.136023230627417 no 437 0.164191747145858 837 1774275 SGTC_2845 9003024 42.97 µM 0.977224970258603 0.136058455679972 no 438 0.164228894276201 827 2990173 SGTC_2308 7584454 197.62 µM 0.976823759581466 0.136152633711458 no 439 0.164328205622803 861 893577 SGTC_278 4092-0821 23.9 µM 0.975354591688545 0.136497879018215 no 440 0.164692199804592 838 877900 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.969595775472833 0.137856935461966 no 441 0.166124009744085 815 688662 SGTC_2468 5987765 72.9 µM 0.969562812230451 0.137864741128049 no 442 0.16613222844812 875 26772094 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.968698507802437 0.138069515243075 no 443 0.166347818651858 862 688751 SGTC_2742 clothiapine 36.27 µM 0.968375911814091 0.13814599897685 no 444 0.166428332567401 790 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2669 eugenol 100 µM 0.966290247493462 0.138641182708964 no 445 0.166949482362045 783 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_507 nimesulide 162 µM 0.962738841228691 0.139487146166292 no 446 0.167839299707618 854 4495 A COX2 inhibitor. SGTC_2046 4110841 106 µM 0.962360375872684 0.139577505158537 no 447 0.167934305240511 859 44119630 YMR134W ERG29 SGTC_2745 rifampicin 24.3 µM 0.962232551137073 0.13960803243596 no 448 0.167966400691215 712 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1382 3002-2117 298 µM 0.962166254491088 0.139623867279171 no 449 0.167983048638604 905 1497314 SGTC_941 3237-0776 460 µM 0.957183834545097 0.140817405665256 no 450 0.169237237446591 827 760008 SGTC_2347 9049783 174.81 µM 0.956989585029015 0.140864077905589 no 451 0.169286255931973 884 6467988 YPL169C MEX67 SGTC_2524 avocatin b 10.57 µM 0.955818005449761 0.141145795294867 no 452 0.169582094976267 807 6710748 SGTC_2782 7736369 71.43 µM 0.952465146999479 0.141954131763049 no 453 0.170430566803259 871 2950836 YOL077C BRX1 SGTC_730 1436-0052 41.2 µM 0.951482026315819 0.142191744175942 no 454 0.170679869171874 829 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_41 0478-0632 82.643 µM 0.950701761250869 0.14238051948229 no 455 0.170877896938823 930 3750424 SGTC_2532 xanthone 78.9 µM 0.950506893544973 0.14242769171623 no 456 0.170927376420399 775 7020 An insecticide. SGTC_14 0354-0009 295 µM 0.950227309206922 0.142495390032554 no 457 0.170998382581265 876 1713507 SGTC_1064 honokiol 6.76 µM 0.949929597976255 0.14256750150159 no 458 0.171074013178341 855 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1969 st069479 40.1 µM 0.948467775746777 0.142921941417206 no 459 0.171445685058797 816 3895485 SGTC_2983 9022671 12.99 µM 0.947376250736383 0.143186985440814 no 460 0.171723544250213 824 6405161 SGTC_281 1672-3440 14.9 µM 0.946232625439076 0.143465036389121 no 461 0.172014974506787 913 6833000 SGTC_2084 5306078 60.6385 µM 0.942809016437629 0.144299600290055 no 462 0.172889299507375 840 679340 SGTC_809 3998-0021 90 µM 0.939899998655797 0.145011290321081 no 463 0.173634429018259 856 715485 SGTC_2252 omeprazole 400 µM 0.938762380592027 0.145290249718518 no 464 0.173926378814357 783 4594 A proton pump inhibitor. SGTC_3341 9147222 25.867 µM 0.938411134270181 0.145376452984252 no 465 0.174016583075279 812 1939759 SGTC_2644 guaiazulene 100 µM 0.937672077029066 0.145557945574344 no 466 0.174206478934508 884 3515 A coloring agent. SGTC_386 1509-0011 3.07 µM 0.937185533507007 0.14567751071844 no 467 0.174331564926945 934 3107280 SGTC_2791 5663188 71.43 µM 0.936167846773455 0.145927814553719 no 468 0.174593387552548 840 54690634 SGTC_1141 3253-0389 52.6 µM 0.934741050382931 0.146279226779076 no 469 0.174960882976678 869 5402031 SGTC_3144 9087057 49.47 µM 0.933555146195398 0.146571740671838 no 470 0.175266705796672 858 17249618 SGTC_2147 5545932 89.7195 µM 0.933427576286269 0.146603230303524 no 471 0.175299623905517 861 797404 SGTC_452 diindolylmethane 8 µM 0.932230154326055 0.146899025834212 no 472 0.175608797456007 801 3071 Inhibits expression of several cancer promoting factors. SGTC_1420 4'-methoxyflavone 42 µM 0.931307121779239 0.147127312813127 no 473 0.175847359533765 890 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3040 9091894 49.47 µM 0.929090361982392 0.147676539105291 no 474 0.176421129435117 801 25236966 SGTC_938 3126-1755 342 µM 0.927984922379538 0.147950936222924 no 475 0.176707695398626 924 1777771 SGTC_625 k213-0058 121 µM 0.924278201896005 0.148873524400162 no 476 0.177670744451551 1018 3655420 SGTC_1996 st072960 66.8 µM 0.92401197421528 0.148939935074095 no 477 0.177740040735335 907 1719405 SGTC_1246 0422-0085 105 µM 0.923842809003303 0.148982143732734 no 478 0.17778408153094 907 264295 SGTC_2429 5902844 64.44 µM 0.923767415193462 0.149000957926343 no 479 0.177803711917458 932 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2292 7671323 168.05 µM 0.923247962802524 0.149130628126034 no 480 0.177938999587654 865 937504 SGTC_411 enrofloxacin 100 µM 0.921860319435774 0.149477393163298 no 481 0.178300719630698 936 71188 A bacterial gyrase inhibitor. SGTC_206 4546-0025 72.014 µM 0.920359896124489 0.149852946427067 no 482 0.178692359255338 924 6620745 YIL048W NEO1 SGTC_3324 9138759 60.749 µM 0.919955439207953 0.149954288859296 no 483 0.178798022977566 881 45595710 SGTC_788 1182-0090 188 µM 0.918760600013224 0.150253939688314 no 484 0.179110402467849 994 5715185 SGTC_185 k048-0037 25.491 µM 0.918728245892 0.150262059245454 no 485 0.179118865920602 917 6827589 SGTC_3095 9117207 49.47 µM 0.918306991838129 0.150367803420637 no 486 0.179229083924994 849 17015229 SGTC_279 1273-0055 2.93 µM 0.917496489720992 0.150571396996973 no 487 0.17944126575864 964 2847562 SGTC_1834 st055981 52.8 µM 0.917094671507172 0.150672399517289 no 488 0.179546516514756 907 471719 YDL150W RPC53 SGTC_1877 wortmannin 25 µM 0.911306826401421 0.152132258654516 no 489 0.18106686531138 932 312145 A covalent inhibitor of PI 3-kinase. SGTC_2941 9056145 11.23 µM 0.911156663309734 0.152170258643608 no 490 0.181106417134968 820 2119517 SGTC_2829 7992743 58.44 µM 0.910784613086053 0.152264436122529 no 491 0.181204435667576 914 16462845 SGTC_891 0929-0073 133 µM 0.909388827363905 0.152618097710956 no 492 0.181572458621518 909 5603632 SGTC_1923 st058458 19.1 µM 0.90693886671109 0.1532401809584 no 493 0.182219563175634 965 3534982 SGTC_2156 5649887 115 µM 0.905544052949167 0.15359509548796 no 494 0.182588616388479 978 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1261 0712-0010 12.7 µM 0.905052799918838 0.153720225799458 no 495 0.182718707905037 934 2840123 SGTC_3152 9099253 49.47 µM 0.903938646638845 0.154004269186176 no 496 0.183013967574888 963 25236131 SGTC_222 nsc-310342 10.666 µM 0.903781322206518 0.154044405601789 no 497 0.183055683800312 849 432556 SGTC_1188 1403-0014 4.57 µM 0.903509190520212 0.154113847840019 no 498 0.183127856379313 944 9614867 SGTC_1032 k061-1018 98.7 µM 0.902867465667081 0.154277684401619 no 499 0.183298119757189 975 4005393 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.902707063001328 0.154318654240206 no 500 0.183340693443022 968 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1520 flindersine 88 µM 0.90217415256282 0.154454821177377 no 501 0.18348218150085 941 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1004 4084-0029 199 µM 0.900528302565139 0.154875862865332 no 502 0.183919585247341 960 716894 YLR208W SEC13 SGTC_2863 9028737 58.44 µM 0.899696351126741 0.1550889810543 no 503 0.184140932873039 921 6460917 SGTC_1377 2944-0135 198 µM 0.899478429364984 0.155144837323099 no 504 0.184198940171457 934 1894137 SGTC_57 miconazole 162.5 nM 0.898217323651174 0.155468336406065 no 505 0.184534849701298 873 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2963 9082507 9 µM 0.897957435452284 0.155535058245359 no 506 0.18460412112951 844 16459611 SGTC_1216 1165-0504 9.65 µM 0.897459083151399 0.155663054488115 no 507 0.184736998764065 934 6304004 SGTC_763 3453-1109 128 µM 0.897002696830122 0.15578033316019 no 508 0.184858738989734 946 1560353 SGTC_189 3970-0742 2.116 µM 0.895152254298185 0.15625644261473 no 509 0.185352851929218 944 2891807 SGTC_2014 4013930 200 µM 0.894572664114793 0.15640576515817 no 510 0.185507785016226 976 64556 SGTC_2804 7954240 19.48 µM 0.894201865169285 0.156501345110185 no 511 0.185606947243262 930 828705 SGTC_2458 5808907 16.39 µM 0.892946492686866 0.156825224915202 no 512 0.185942913810656 991 2731747 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.891814359248415 0.157117687634103 no 513 0.186246221926832 758 4000243 SGTC_39 0986-0283 58.349 µM 0.891717223597842 0.1571427972714 no 514 0.186272259661374 982 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2717 st081029 62.2815 µM 0.890682085325251 0.157410545176377 no 515 0.186549874127599 910 5292846 SGTC_2629 bisabolol 100 µM 0.889294468011768 0.157769935102116 no 516 0.186922421899427 932 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1379 2144-0755 36.5 µM 0.887619331340134 0.158204509386448 no 517 0.187372775767312 983 5392327 SGTC_3334 9142812 21.919 µM 0.886804129520417 0.158416277966263 no 518 0.187592181976396 884 45283678 SGTC_228 caffeine 993.056 µM 0.884620904685413 0.158984339374276 no 519 0.188180564000242 889 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_406 estrone 100 µM 0.883198735334953 0.159355095958226 no 520 0.188564452390446 961 5870 A steroid. SGTC_291 SEC14.278 35.5 µM 0.882831358731708 0.159450962209781 no 521 0.188663697353451 963 1068044 SGTC_3164 9100705 49.47 µM 0.882378611137253 0.159569157789395 no 522 0.188786049149424 918 17174235 SGTC_1341 1486-1360 280 µM 0.881350025864719 0.159837896268972 no 523 0.189064198648092 924 3976547 SGTC_734 2023-0417 80 µM 0.876998930988605 0.16097798009155 no 524 0.190243609357605 916 3935732 SGTC_3042 9091578 49.47 µM 0.876551652673457 0.161095477088893 no 525 0.19036510459195 919 25236497 SGTC_3010 9080089 71.4286 µM 0.875369158317894 0.161406379858078 no 526 0.190686537707814 943 17027233 SGTC_182 3448-4371 550.524 µM 0.874880717914952 0.161534915286644 no 527 0.190819405833447 1005 3491403 SGTC_2226 7298446 200 µM 0.874544939287856 0.161623315735403 no 528 0.190910779040345 928 3283010 SGTC_1418 3966-3099 2.4 µM 0.872466436394061 0.162171224878998 no 529 0.191476985330328 949 740335 SGTC_2077 5212015 200 µM 0.870544324269397 0.162678983343028 no 530 0.192001503747572 902 780900 SGTC_3224 9130643 49.47 µM 0.869273877679607 0.163015160369049 no 531 0.192348673649696 921 17644395 SGTC_958 1222-0007 33 µM 0.869158411882412 0.163045736522714 no 532 0.192380245549284 996 7312461 SGTC_1615 st002656 86.5 µM 0.864698279464904 0.164229663674196 no 533 0.193602207029366 934 1584458 SGTC_3133 9127736 49.47 µM 0.864492546438874 0.16428440899101 no 534 0.19365868655478 950 27243420 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.863048106925334 0.164669105791396 no 535 0.194055508826235 799 6708630 An antioxidant. SGTC_3139 9095020 49.47 µM 0.857538457768765 0.166141842039123 no 536 0.195573685137695 795 25236292 SGTC_1714 st033236 13.627 µM 0.857078524878496 0.166265166321135 no 537 0.195700744338756 975 2916566 SGTC_863 0466-0191 129 µM 0.856634083511738 0.166384392931658 no 538 0.195823571508046 997 765160 YPR165W RHO1 SGTC_3253 9135987 49.47 µM 0.855689673312947 0.16663792528532 no 539 0.196084726868296 916 4182430 SGTC_1603 st002045 67.8 µM 0.855181793357114 0.166774371620325 no 540 0.196225256930144 987 5887985 SGTC_712 r015-0009 80.6 µM 0.854587497040069 0.166934125955436 no 541 0.19638977585853 896 6813872 YLR060W FRS1 SGTC_1755 st041960 45.185 µM 0.854374991252624 0.166991274136409 no 542 0.196448624078774 965 2257073 SGTC_602 3130-1533 38.1 µM 0.854339688137665 0.167000769258903 no 543 0.196458401438074 1002 720941 SGTC_2038 4100038 30.985 µM 0.853242151966131 0.167296136148914 no 544 0.19676251618529 934 3596803 SGTC_3292 9120825 59.784 µM 0.85249587556055 0.167497164849688 no 545 0.196969463601204 1001 24824900 SGTC_2370 9071495 200 µM 0.851991903372999 0.16763301069056 no 546 0.197109292947416 904 21791103 SGTC_76 0433-0009 400.328 µM 0.851783408348185 0.167689231326779 no 547 0.197167158389799 866 2841569 SGTC_3176 9106582 49.47 µM 0.851049899635241 0.167887118279106 no 548 0.197370817135386 871 17018027 SGTC_2462 5162487 171.77 µM 0.850781739238017 0.167959500456335 no 549 0.19744530363522 985 2259986 SGTC_2045 5106652 78.05 µM 0.848855675403923 0.168479976050938 no 550 0.197980802752432 988 673349 SGTC_1401 3807-4679 7.6 µM 0.848593030461161 0.168551030225548 no 551 0.198053893226526 938 3291456 SGTC_3014 9081533 49.47 µM 0.84774315860864 0.168781080773426 no 552 0.198290512516102 980 21367265 SGTC_138 0850-0259 40.9225 µM 0.846373769860603 0.169152182832471 no 553 0.198672133212425 1021 6813004 SGTC_2407 paclitaxel 400 µM 0.845777047202804 0.169314057444575 no 554 0.198838566093215 979 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3021 9087658 49.47 µM 0.844210831601346 0.169739401926329 no 555 0.199275801440542 989 25237042 SGTC_373 0844-0104 25.9 µM 0.842820570912068 0.170117535135354 no 556 0.199664400699198 1029 5375804 SGTC_2278 7948257 134.34 µM 0.840891683862268 0.170643061202227 no 557 0.200204308836761 997 1247028 SGTC_651 3253-0966 34.4 µM 0.839933286050984 0.170904563140181 no 558 0.2004728966272 1005 781462 SGTC_3064 1327-0027 10 µM 0.837564244352872 0.171552063385748 no 559 0.201137740647674 869 16000455 YPR107C YTH1 SGTC_844 0330-0132 15.3 µM 0.837156809655995 0.171663580137682 no 560 0.201252215572907 1047 2828079 SGTC_1891 st059073 26.2 µM 0.833636282890196 0.172629092699432 no 561 0.202242986666908 1070 688754 SGTC_2061 5245884 80.95 µM 0.833473838793959 0.172673726773723 no 562 0.202288773124707 998 573863 SGTC_3155 9099265 49.47 µM 0.832100400261057 0.173051394666728 no 563 0.202676137970093 911 25236499 SGTC_1142 3253-1408 9.78 µM 0.831597745157485 0.173189746112532 no 564 0.20281801763666 978 256655 SGTC_1851 st056236 18.9 µM 0.830535957295892 0.173482225469317 no 565 0.20311791335984 1045 5393171 SGTC_1309 pyrazolanthrone 13.4 µM 0.829632850796042 0.173731241825336 no 566 0.203373198695715 1045 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2348 9022543 33.42 µM 0.828932587131998 0.173924484126066 no 567 0.203571277206947 996 3162678 YDL140C RPO21 SGTC_2831 7999036 19.48 µM 0.828626029661956 0.174009123646607 no 568 0.203658027095711 1015 2988270 SGTC_1650 st011916 45.8 µM 0.828215094933764 0.174122622460742 no 569 0.203774348320158 1012 242528 SGTC_2621 lithochol-11-enic acid 100 µM 0.827055941106895 0.174443030421355 no 570 0.20410267750983 1025 6708711 SGTC_2986 9022445 71.43 µM 0.826826168116413 0.174506587661732 no 571 0.204167797888446 999 6459286 SGTC_546 peri-Naphthalide 147 µM 0.826215351565696 0.174675616424399 no 572 0.2043409706726 998 223824 A penicillin ester. SGTC_2262 9014885 67.46 µM 0.824843718500208 0.175055561474254 no 573 0.204730161297837 963 6457424 SGTC_2919 7978188 46.38 µM 0.82430357214307 0.175205326852948 no 574 0.204883544710098 1012 2980291 SGTC_2746 daunorubicin 9.88 µM 0.823075627132616 0.175546099134748 no 575 0.205232493960136 896 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1717 st033143 58.0435 µM 0.822774033015098 0.175629860022643 no 576 0.205318252953488 1021 674616 SGTC_2910 7948405 25.97 µM 0.822297232199536 0.175762332231702 no 577 0.205453875801438 988 2971328 SGTC_2896 9052656 71.43 µM 0.820289376434936 0.176320880175869 no 578 0.206025580567061 1018 6469436 SGTC_2748 diazoxide 86.69 µM 0.81843831117993 0.176836805772146 no 579 0.206553476639314 933 3019 A potassium channel activatior. SGTC_2281 7943571 200 µM 0.818131751440284 0.176922341562175 no 580 0.206640980150008 1102 1244024 SGTC_3271 9137798 49.47 µM 0.817178305565313 0.177188537530499 no 581 0.206913269214821 949 6498326 SGTC_84 0443-0269 128.823 µM 0.817108059877419 0.177208159676084 no 582 0.206933338667668 1011 6150058 SGTC_3061 glucosamine 200 µM 0.81386245588772 0.178116269825457 no 583 0.207861875415841 1005 91431 and experimental redox chemotherapeutic SGTC_1726 st035556 14.5795 µM 0.813654175824294 0.178174645954206 no 584 0.207921546276238 1041 5919439 SGTC_2909 7941780 10.49 µM 0.81240741482179 0.1785243365966 no 585 0.208278946481521 1035 1243215 SGTC_1972 st070201 17.4 µM 0.812059655483698 0.178621952941561 no 586 0.20837870081424 1016 2829099 SGTC_561 1550-0330 72.9 µM 0.811045084316637 0.17890693597219 no 587 0.208669890278226 992 6812934 SGTC_403 arphamenine a 50 µM 0.810142933353542 0.179160581485586 no 588 0.208929015649225 1019 5487158 An arginine aminopeptidase inhibitor. SGTC_1191 1487-1166 10.6 µM 0.810064577832618 0.17918262231278 no 589 0.208951530696434 1100 3955771 SGTC_1546 5-methoxyflavanone 78.7 µM 0.808953834079427 0.179495249728637 no 590 0.209270850777822 1066 147795 SGTC_132 0417-1715 25.805 µM 0.808856931720116 0.179522539897857 no 591 0.209298722186196 1060 6769098 SGTC_1872 amphotericin b 148 nM 0.80835878752461 0.179662871133632 no 592 0.209442034707922 1057 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_666 0272-0154 136 µM 0.807481053336525 0.179910303604536 no 593 0.209694693001481 1027 6870312 SGTC_2174 5790901 200 µM 0.807479923715016 0.179910622181643 no 594 0.209695018281694 999 786020 SGTC_2522 biochanin a 4.94 µM 0.806251084764067 0.180257390506379 no 595 0.210049044344485 1015 5280373 A possible chelator. SGTC_409 arachidonic acid 100 µM 0.806222760113015 0.180265388434305 no 596 0.210057208758587 1051 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_468 gf-109203x 121 µM 0.805980800517133 0.180333718755187 no 597 0.210126959787978 949 2396 A protein kinase C inhibitor. SGTC_1948 st076329 66.6 µM 0.8045229034071 0.180745778416138 no 598 0.210547523719152 978 24208413 SGTC_2545 solidagenone 89.61 µM 0.803639127438092 0.180995855769341 no 599 0.210802709521734 853 6708572 An anti ulcer agent SGTC_784 4579-0127 173 µM 0.803589118750056 0.181010012938172 no 600 0.210817154695862 1080 1948547 SGTC_1653 st012112 65 µM 0.802919656598057 0.181199600593026 no 601 0.211010586938964 1018 720429 SGTC_2861 9024595 19.48 µM 0.802203948298611 0.181402422381682 no 602 0.211217496421826 986 16482810 SGTC_1624 st003710 6.25 µM 0.801831443431652 0.181508041302703 no 603 0.211325233670034 1087 24207033 SGTC_258 haloperidol 50.781 µM 0.799021031670624 0.182306137313659 no 604 0.212139108476228 1027 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1027 k015-0025 8.67 µM 0.798452125878449 0.182467960703567 no 605 0.21230408220701 1063 3598955 SGTC_2837 9008476 45.46 µM 0.797000108144902 0.182881388993743 no 606 0.212725484256324 1033 2992805 SGTC_1212 0520-0165 585 µM 0.79606670896095 0.183147461160288 no 607 0.21299663141035 1022 5403258 SGTC_360 0957-0399 1.01 µM 0.794166353921037 0.183689916852863 no 608 0.213549296543895 1063 6752301 YPR165W RHO1 SGTC_235 0330-0087 5 mM 0.793574026634428 0.183859200899837 no 609 0.213721729043457 1092 46494818 YHR062C RPP1 SGTC_565 1418-0001 44.5 µM 0.792533123424522 0.184156920920899 no 610 0.214024942959485 1079 2862145 SGTC_1509 1326-1131 80 µM 0.791297803596915 0.184510637278046 no 611 0.21438511491718 1021 768313 SGTC_2013 4024628 200 µM 0.790739150831809 0.18467073825842 no 612 0.214548112350615 1031 5230760 SGTC_357 1325-0123 420 µM 0.7907381356002 0.184671029286225 no 613 0.214548408629064 1043 1098503 SGTC_2879 9041815 71.43 µM 0.788068751025475 0.18543722492441 no 614 0.215328246223093 998 4942971 SGTC_2756 carbadox 75.1 µM 0.786997723060105 0.185745196854516 no 615 0.215641599530148 1015 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1492 4158-0558 28.5 µM 0.786641543243476 0.185847685904472 no 616 0.215745866497462 1051 3967268 SGTC_512 prima-1 270 µM 0.786380965065958 0.185922688247605 no 617 0.215822165846837 1073 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1991 st073000 8.92 µM 0.786055276591944 0.186016457704843 no 618 0.215917551990345 1072 4301969 YIL048W NEO1 SGTC_2201 6605497 169.863 µM 0.78405156688696 0.186593993625878 no 619 0.216504926462655 1058 670741 SGTC_502 l-744,832 89.3 µM 0.781765417241833 0.187254292604903 no 620 0.217176224248618 1067 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_367 0335-0881 7.1 µM 0.780165320786208 0.187717300104744 no 621 0.21764678598393 1051 23828853 SGTC_261 5-fluorouridine 15.376 µM 0.778904732051397 0.188082564457258 no 622 0.218017918116908 1039 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_133 0724-0033 378.92 µM 0.778119175322689 0.18831040669255 no 623 0.218249379651074 1006 280309 SGTC_31 0508-1974 57.237 µM 0.776001596498489 0.188925435188043 no 624 0.218874021611366 1048 6810525 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.775283045973438 0.189134411531625 no 625 0.219086212646112 1110 94937 An inhibitor of serotonin biosynthesis. SGTC_2003 4023581 200 µM 0.77505102019661 0.189201922076391 no 626 0.219154756104547 1066 16641307 SGTC_2739 tacrine 100.86 µM 0.770666756301886 0.190480361217561 no 627 0.220452240690918 1084 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1600 coumarin 106 71.1 µM 0.769833646838029 0.190723891988905 no 628 0.220699288977869 1083 100336 A hepatotoxic, DNA x-linker. SGTC_223 busulfan 5 mM 0.76844626164967 0.191129869950902 no 629 0.221111052576319 1017 2478 A DNA alkylator. SGTC_446 go6976 132 µM 0.767324998388922 0.191458361922578 no 630 0.221444154498232 1073 3501 A protein kinase C inhibitor. SGTC_216 k038-0035 28.382 µM 0.767194488538832 0.191496619329318 no 631 0.22148294465074 1037 4444231 YPR107C YTH1 SGTC_2351 9026858 72.31 µM 0.766688217167461 0.191645071065836 no 632 0.221633455440687 1056 1409300 SGTC_152 4469-0003 551.229 µM 0.763767049908786 0.192503008062098 no 633 0.222503037944146 1096 697280 SGTC_26 0302-0163 425.158 µM 0.763462733637262 0.192592519568971 no 634 0.222593739557174 1115 3100915 SGTC_3299 9121982 43.1275 µM 0.763022556418731 0.192722038180583 no 635 0.222724971880246 1127 17594604 YPL160W CDC60 SGTC_3045 9092950 49.47 µM 0.761266372171501 0.193239310841883 no 636 0.223248990917231 1118 44120432 SGTC_1866 st057638 64 µM 0.761013394663071 0.193313893485858 no 637 0.223324533392915 1073 688802 SGTC_1625 st003711 30.1 µM 0.760827319514566 0.193368763235662 no 638 0.223380107210723 1114 24207034 YER133W GLC7 SGTC_3262 9137218 49.47 µM 0.760327223328405 0.193516278440745 no 639 0.223529506575632 971 17650664 SGTC_2402 5553605 200 µM 0.759810300420061 0.193668829210379 no 640 0.223683992494264 1114 6758546 SGTC_780 0109-0199 192 µM 0.757453309290364 0.19436533736744 no 641 0.224389164251491 1139 610414 SGTC_3111 9122088 49.47 µM 0.757244675285332 0.194427063631083 no 642 0.224451644736163 1023 16876704 SGTC_1039 k821-0043 94 µM 0.756380920423362 0.19468274029066 no 643 0.22471042198589 1112 15992768 SGTC_140 0062-0056 502.533 µM 0.755143043933031 0.195049515664763 no 644 0.225081579313125 1132 3758964 SGTC_2736 butenafine 14.65 µM 0.753834694155714 0.195437628125719 no 645 0.225474244230031 1104 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_593 1203-0218 61.7 µM 0.751323881247282 0.196183755186918 no 646 0.226228880150463 1155 3666956 SGTC_540 1187-0821 17.3 µM 0.749690428010778 0.196670087285714 no 647 0.226720586912412 1075 847520 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.74913378235605 0.196835985473664 no 648 0.226888287652078 1105 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_462 ag-879 158 µM 0.748419860750588 0.197048880905971 no 649 0.227103473325608 1144 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1345 1488-0192 31.4 µM 0.746258367283146 0.197694299596536 no 650 0.227755677841259 1155 658348 SGTC_2052 5265182 7.135 µM 0.746227832875718 0.197703426266623 no 651 0.227764898774436 1109 1239884 SGTC_127 0180-0333 59.125 µM 0.745536689156855 0.197910075773197 no 652 0.227973670007375 1119 771601 SGTC_635 k038-0028 24.7 µM 0.744347120611475 0.198266057930321 no 653 0.228333250542964 1126 4035102 SGTC_1158 4092-0494 91.8 µM 0.743576579476024 0.198496850919767 no 654 0.228566338266814 1163 1148199 SGTC_64 000l-0018 272.079 µM 0.742508272339337 0.198817098965495 no 655 0.228889720814793 1108 6811119 SGTC_2518 prenyletin 46.28 µM 0.742485502562061 0.198823928084415 no 656 0.228896616147417 1045 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.741343387415916 0.199166653031835 no 657 0.22924263045796 1090 17037758 SGTC_799 1310-0557 151 µM 0.740807966530233 0.199327444121983 no 658 0.229404942070487 1116 5354492 SGTC_402 epigallocatechin gallate 10 µM 0.740086682665869 0.199544174854406 no 659 0.229623699416357 1108 65064 An antioxidant. SGTC_1125 tnp00248 1.32998 µM 0.739877679182001 0.19960700252807 no 660 0.229687109669698 1228 24207736 SGTC_2010 4012422 159 µM 0.739703692242408 0.199659313101453 no 661 0.229739903618255 1099 952393 SGTC_1242 0402-0103 60.1 µM 0.739587797438455 0.199694162383625 no 662 0.229775074076287 1102 432868 SGTC_2525 harmine 47.85 µM 0.738881460731513 0.199906635202004 no 663 0.229989490404663 1078 5280953 A monoamine oxidase inhibitor SGTC_1556 plumbagin 1.48 µM 0.738103927028805 0.200140681883926 no 664 0.230225648792905 1056 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_990 3985-0011 41.3 µM 0.737974571875451 0.200179635261718 no 665 0.230264950668698 1071 5399565 YGL099W LSG1 SGTC_109 0132-0036 33.701 µM 0.737814168383695 0.200227944711858 no 666 0.230313691147894 1015 67274 A color developer. SGTC_1753 st043925 64 µM 0.737340420818746 0.200370666320675 no 667 0.230457678569558 1145 670181 SGTC_2096 5468907 200 µM 0.73653297033624 0.200614060365669 no 668 0.230703205181175 1150 759785 SGTC_413 propylparaben 100 µM 0.734063426488857 0.201359568887577 no 669 0.231455041294035 1126 7175 A pharmaceutical preservative. SGTC_797 k781-0471 270 µM 0.733388902488551 0.201563483272968 no 670 0.231660632893312 1140 23738129 SGTC_3125 9127534 49.47 µM 0.733209560538475 0.201617720694394 no 671 0.231715312559324 1037 1639235 SGTC_3186 9110464 49.47 µM 0.732580954384136 0.201807895688023 no 672 0.231907025402654 1130 17018021 SGTC_1654 st012436 41.8 µM 0.731308850663976 0.202193079315526 no 673 0.232295262817688 1102 4323132 SGTC_2921 7974240 10.71 µM 0.728656483223916 0.202997609877996 no 674 0.233105909154871 1133 2979074 YDR527W RBA50 SGTC_384 k007-0144 5.16 µM 0.728386730335937 0.203079539757809 no 675 0.233188441964753 1144 6824886 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.727926359396448 0.203219410119178 no 676 0.233329333175903 1168 4213774 SGTC_3314 9135860 59.4275 µM 0.727123798402563 0.203463382454884 no 677 0.233575060612635 1154 25252478 SGTC_2763 lisinopril 49.32 µM 0.72602673163045 0.203797164786694 no 678 0.233911191611515 1109 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_720 r052-1644 49.9 µM 0.725703816424016 0.203895473811279 no 679 0.234010180839571 1112 1422863 YOR257W CDC31 SGTC_1252 0493-0875 34.8 µM 0.724999355671932 0.204110039467253 no 680 0.234226212854676 1157 3960963 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.724794248689828 0.204172536514447 no 681 0.234289132314058 1171 688761 SGTC_415 dibenzyl ketone 100 µM 0.724311832490863 0.204319575884147 no 682 0.234437157159261 1135 7593 SGTC_3071 9117417 49.47 µM 0.724261243066282 0.204334999078252 no 683 0.234452683042636 1086 45595590 YGL055W OLE1 SGTC_991 3996-0057 64.7 µM 0.724225998479282 0.204345744502508 no 684 0.234463499934923 1109 715343 SGTC_2811 7967822 32.47 µM 0.722487402000777 0.204876227989527 no 685 0.234997434019396 1142 2232244 SGTC_670 4204-0025 119 µM 0.722022450478961 0.20501823343743 no 686 0.235140337368197 1163 719039 SGTC_685 1278-0033 54.9 µM 0.719599015216922 0.205759345501544 no 687 0.235885959268209 1180 3590572 SGTC_351 caspofungin 25 nM 0.719397939591797 0.205820907890812 no 688 0.235947883001411 1222 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2820 7989630 71.43 µM 0.717148292264977 0.206510416765865 no 689 0.236641300292394 1060 2984098 SGTC_568 1193-0097 7.48 µM 0.717119461478596 0.206519262170232 no 690 0.236650194184455 1087 3646150 SGTC_287 k060-0039 29.6 µM 0.716910252696376 0.206583455011815 no 691 0.236714737659252 1178 5861974 SGTC_3108 9121785 49.47 µM 0.716438557642204 0.206728231515173 no 692 0.236860296886789 1140 17140271 SGTC_3049 9092223 49.47 µM 0.713380052965233 0.207668429434006 no 693 0.237805306430571 1120 8623917 SGTC_1151 3909-8316 15.3 µM 0.713097518514184 0.207755409058131 no 694 0.237892707470072 1189 800431 SGTC_1795 st049545 62.3 µM 0.712619802504106 0.207902525230314 no 695 0.238040527299278 1151 5291882 SGTC_3166 9102297 49.47 µM 0.71139179401631 0.208280981700375 no 696 0.238420741328139 1142 25237072 SGTC_3114 9122766 49.47 µM 0.710881946985091 0.208438229345711 no 697 0.238578696991039 1119 17176985 SGTC_1413 3910-0535 34.4 µM 0.708496183578056 0.209174979207358 no 698 0.239318590673336 1184 2876951 SGTC_1563 conessine 56.1 µM 0.708256778655598 0.2092489946164 no 699 0.239392906147843 1253 441082 An anti-amoebic, histamine inhibitor. SGTC_3269 9137823 49.47 µM 0.707968708098606 0.209338076125318 no 700 0.239482344991095 1120 17682936 SGTC_2305 7443522 69.23 µM 0.707129827782857 0.209597614405878 no 701 0.23974290065362 1153 5415886 SGTC_323 4013-0906 34.3 µM 0.706080884710408 0.209922409407735 no 702 0.240068919182768 1205 2910086 SGTC_2584 androsterone 48.74 µM 0.705580920378743 0.210077322528322 no 703 0.240224396459295 1249 2754130 A steroid. SGTC_2444 5485484 36.41 µM 0.704480220791913 0.210418609072101 no 704 0.240566881723767 1211 6790631 SGTC_1494 4358-1428 177 µM 0.703131041647233 0.210837383674274 no 705 0.24098704437064 1219 1564571 SGTC_3136 9095672 49.47 µM 0.702941350610354 0.210896301447413 no 706 0.241046150116739 1039 17217380 SGTC_1162 k048-0130 20.1 µM 0.698855934328203 0.212167567389754 no 707 0.242321034236047 1165 6797406 SGTC_751 0833-0568 350 µM 0.698232290933598 0.212362020939951 no 708 0.242515967690646 1215 6954252 SGTC_522 1273-0010 11.6 µM 0.695339015013414 0.213265512804722 no 709 0.243421434697056 1254 5705015 SGTC_3 0833-0587 95.581 µM 0.695231599392154 0.213299098894971 no 710 0.243455086150838 1143 5382644 SGTC_1361 1608-0041 5.61 µM 0.693900878944115 0.213715436497883 no 711 0.243872186176664 1196 X1361 SGTC_2157 5649910 96.377 µM 0.693182767422141 0.213940305907265 no 712 0.244097430615079 1187 2858091 SGTC_3242 9133940 49.47 µM 0.6929516017591 0.214012722409501 no 713 0.244169962409826 1242 17248444 SGTC_2439 5492030 7.2 µM 0.692019556471993 0.214304845850919 no 714 0.244462523855163 1171 5722370 SGTC_3257 9139206 32.98 µM 0.690791657415578 0.21469005018842 no 715 0.244848239521012 1171 4910041 SGTC_3201 9113999 49.47 µM 0.690342196666546 0.214831151101237 no 716 0.244989508913243 1175 16649224 SGTC_1266 0828-0227 32.9 µM 0.689470000337113 0.215105116648526 no 717 0.245263772814136 1161 3913820 SGTC_2163 5671233 125 µM 0.688807195811616 0.215313445715164 no 718 0.245472303366971 1247 701023 SGTC_505 gw-5074 63.9 µM 0.688800247592688 0.21531563026098 no 719 0.245474489909496 1204 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_51 1013-0126 23.419 µM 0.688295506867462 0.215474357016417 no 720 0.245633355301682 1282 1627850 SGTC_1758 st042942 75.2445 µM 0.687959961270169 0.215579914212283 no 721 0.24573899766206 1187 669317 SGTC_2207 7258803 200 µM 0.687283611591118 0.215792773953359 no 722 0.245952012071881 1168 3666799 SGTC_1961 st076550 68.7 µM 0.686531537693575 0.216029608483457 no 723 0.246188991902213 1184 1579337 SGTC_760 0568-0725 82.9 µM 0.686404700269609 0.216069565510652 no 724 0.246228970664384 1217 3916171 SGTC_2567 aureobasidin a 60 nM 0.684822555388346 0.216568341156628 no 725 0.246727950214611 1263 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_717 1532-0246 73.2 µM 0.684377123911832 0.216708884760738 no 726 0.246868528765656 1194 9561992 SGTC_1498 4478-3555 97.6 µM 0.684189973753638 0.216767950559314 no 727 0.246927606302094 1186 3437919 SGTC_845 0330-0138 4.51 µM 0.683208292130485 0.217077928064393 no 728 0.247237616823316 1187 9039800 SGTC_3081 9117243 49.47 µM 0.682272428179125 0.217373676435556 no 729 0.247533351994654 1224 45595589 SGTC_1068 loratadine 26.9 µM 0.681634745471544 0.217575327842039 no 730 0.247734969415732 1214 3957 A H1 histamine antagonist. SGTC_1688 st021091 57.6 µM 0.680952529156764 0.217791181387984 no 731 0.247950764167131 1225 3656366 SGTC_3017 9080681 49.47 µM 0.680864627392732 0.217819002525768 no 732 0.247978576042298 1205 16451914 SGTC_3086 9117350 49.47 µM 0.680861210532141 0.217820084012452 no 733 0.247979657161154 1155 2679265 SGTC_1602 st001878 87.6 µM 0.67952877585442 0.218242055240854 no 734 0.248401440575085 1245 595405 YLR310C CDC25 SGTC_506 n9-isopropylolomoucine 153 µM 0.679316488040819 0.218309328538977 no 735 0.248468675772043 1223 6610355 SGTC_3190 9110366 49.47 µM 0.67901110646827 0.218406123888733 no 736 0.248565412368574 1151 17123768 SGTC_2184 6075246 200 µM 0.67894557113777 0.218426899533 no 737 0.24858617479785 1235 2267320 SGTC_2237 6667747 47.222 µM 0.678186177883817 0.218667721133997 no 738 0.248826827637398 1160 729940 YDL015C TSC13 SGTC_2263 7948595 193.29 µM 0.678143592246852 0.218681230572942 no 739 0.248840326760084 1210 2971371 SGTC_791 1348-1292 225 µM 0.676518335855155 0.219197169464952 no 740 0.249355804258053 1232 5437054 SGTC_2211 7117706 200 µM 0.676183181686008 0.21930365137768 no 741 0.249462174613321 1177 822771 SGTC_2009 4012297 12.05 µM 0.674708230525039 0.219772611615139 no 742 0.249930577185711 1214 45595307 SGTC_1913 st060213 96.1 µM 0.674490759476595 0.219841805128729 no 743 0.249999679274407 1250 688959 SGTC_3215 9129942 49.47 µM 0.674490759476595 0.219841805128729 no 744 0.249999679274407 1170 17682944 SGTC_2488 5268135 45.7 µM 0.67365956358661 0.220106384789815 no 745 0.250263887700513 1228 1270356 YLR208W SEC13 SGTC_1224 0823-0416 294 µM 0.671291836536234 0.220861061190569 no 746 0.251017317071231 1264 3598164 SGTC_1022 4477-0945 21.3 µM 0.671063593359128 0.220933888381628 no 747 0.251090009216083 1221 4648966 SGTC_79 0052-0007 94.094 µM 0.6699969993072 0.221274396373255 no 748 0.251429851528508 1284 2801472 SGTC_2078 5212016 200 µM 0.669392052367892 0.221467657785835 no 749 0.251622710042122 1173 1899708 SGTC_3107 9121808 49.47 µM 0.668132616443212 0.221870317149369 no 750 0.252024471739873 1194 662681 SGTC_50 0929-0078 56.389 µM 0.66741478603819 0.222100004560766 no 751 0.252253611914671 1160 1377751 SGTC_1878 temozolomide 1 mM 0.667226292980211 0.222160340020767 no 752 0.252313799390819 1205 5394 DNA alkylating agent. SGTC_1206 3978-0017 132 µM 0.666417877663341 0.222419214823431 no 753 0.252572019288223 1299 3873677 SGTC_1303 1160-0052 261 µM 0.665103697783128 0.222840415051692 no 754 0.252992084849894 1255 3562476 SGTC_1529 apigenin 74 µM 0.664396476562238 0.223067270415069 no 755 0.253218293687716 1317 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2495 cafestol 54.53 µM 0.664270029463664 0.223107844707201 no 756 0.25325874973605 1258 16667697 An anti-infammatory. SGTC_2888 9058547 12.99 µM 0.662527692205926 0.223667352865575 no 757 0.253816546745653 1179 16476514 SGTC_2890 9046729 58.44 µM 0.662225034317756 0.223764625165099 no 758 0.253913506241918 1178 903329 SGTC_1861 st057647 17.4 µM 0.660728296927063 0.224246020313523 no 759 0.254393286723869 1303 688668 SGTC_1742 st038235 28.8875 µM 0.660048909300988 0.224464725415728 no 760 0.254611221700275 1234 564103 YBR002C RER2 SGTC_2825 7998094 58.44 µM 0.659093227995928 0.224772578407387 no 761 0.254917952025645 1242 2987815 SGTC_604 1000-0114 314 µM 0.658897136369846 0.224835774863659 no 762 0.254980912439087 1292 1572745 SGTC_2991 9074669 71.4286 µM 0.658852390440876 0.224850197003884 no 763 0.254995280445496 1268 17333109 SGTC_1828 st055811 49 µM 0.658302188222208 0.225027576531317 no 764 0.255171986089079 1222 5877589 SGTC_3093 9117344 49.47 µM 0.657879684638578 0.225163841143622 no 765 0.255307722866612 1262 24824913 SGTC_1496 4469-0713 57.4 µM 0.657128580216436 0.225406200507465 no 766 0.255549121656945 1235 746691 SGTC_888 0916-0002 6.97 µM 0.656370651048293 0.225650911656997 no 767 0.255792834670699 1299 2802138 YIL048W NEO1 SGTC_1089 terbinafine 2.25 µM 0.655162762612218 0.226041210790684 no 768 0.256181483220868 1257 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_354 2783-3500 4.88 µM 0.654068180723794 0.2263952270705 no 769 0.256533940162245 1229 6740761 SGTC_2338 7999974 200 µM 0.652634431279701 0.226859412309112 no 770 0.256995991374462 1307 315925 SGTC_1825 st052143 62.6 µM 0.652179026389436 0.227006964724733 no 771 0.257142844227233 1295 674173 SGTC_143 4032-1194 15.74 µM 0.651038884073532 0.227376611157924 no 772 0.257510693287779 1290 1806963 SGTC_1178 0988-0033 191 µM 0.648531575310393 0.228190699323526 no 773 0.258320597629514 1269 5392207 SGTC_2747 doxorubicin 7.63 µM 0.648520953613454 0.228194151522411 no 774 0.25832403142807 1165 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2977 9011197 71.43 µM 0.648337659918065 0.228253729141711 no 775 0.258383290622146 1306 2704722 SGTC_1859 st055998 20 µM 0.646585189509641 0.228823791802219 no 776 0.258950222968293 1298 676301 SGTC_2738 aclarubicin 5.55 µM 0.64644419065181 0.228869692156177 no 777 0.258995864707618 1202 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1885 st057546 99.9 µM 0.646033670702971 0.229003361035323 no 778 0.259128774893913 1327 702008 SGTC_318 1488-0629 67.2 µM 0.645142468472203 0.229293694964685 no 779 0.259417432387499 1267 3662576 SGTC_559 1550-0661 158 µM 0.643987733535337 0.229670188746687 no 780 0.259791694150747 1311 5830875 SGTC_1296 1068-0102 11.9 µM 0.643417669744708 0.229856181908897 no 781 0.259976560502818 1250 767053 SGTC_1744 st037937 38.9 µM 0.643067233641943 0.229970559581885 no 782 0.260090237313108 1314 1016152 SGTC_359 0081-0058 15.9 µM 0.64290759442992 0.23002267425179 no 783 0.260142030644485 1399 3494159 SGTC_2447 5741742 33.78 µM 0.642771044122053 0.230067256727779 no 784 0.260186337232235 1329 1776504 SGTC_2179 6298986 200 µM 0.64220808502363 0.230251108975324 no 785 0.260369042083263 1254 738374 SGTC_113 0099-0221 2.5 µM 0.641421481569232 0.230508136984857 no 786 0.260624439951078 1337 89219 SGTC_2080 5212524 12.4 µM 0.640067864337982 0.230950815780454 no 787 0.261064240036587 1259 260183 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.639454654028431 0.23115151247472 no 788 0.261263602019657 1162 88881 An O-methylated flavonoid and antioxidant. SGTC_1808 st050063 61.5 µM 0.638021852926265 0.231620830963021 no 789 0.261729727448219 1299 4011993 SGTC_2350 9023895 38.85 µM 0.637620128277422 0.231752512390969 no 790 0.261860494898316 1317 2997209 SGTC_1487 3970-0795 2.82 µM 0.637287029830653 0.231861730441381 no 791 0.261968948886777 1317 3765103 SGTC_868 0527-0199 213 µM 0.636702095865746 0.232053590987009 no 792 0.262159454066079 1275 2849450 SGTC_2928 9011484 9.79 µM 0.635958673465451 0.232297563836168 no 793 0.262401679215588 1277 2994751 SGTC_2741 miltefosine 3.04 µM 0.635420209933644 0.23247436333237 no 794 0.26257719530196 1227 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1098 clofazimine 15.1 µM 0.635109996970505 0.23257625283958 no 795 0.262678338733942 1336 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1794 st048918 76.9 µM 0.63359728311334 0.233073459550542 no 796 0.263171837181247 1230 672303 SGTC_3246 9135460 32.98 µM 0.633157653669299 0.233218069868836 no 797 0.263315347961012 1245 41446951 SGTC_1715 st032160 10.2275 µM 0.632672805227822 0.233377612112587 no 798 0.263473666166639 1240 5289825 SGTC_3124 9127567 49.47 µM 0.632369638411337 0.233477401705621 no 799 0.263572684312012 1265 17592030 SGTC_2248 tofa 1.1 µM 0.632004557639777 0.233597602138389 no 800 0.26369194954017 1290 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.631647143087949 0.233715311752355 no 801 0.263808737015012 1285 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2311 7694451 200 µM 0.630324149173078 0.234151307755089 no 802 0.264241263060224 1290 2163142 SGTC_969 1313-0238 134 µM 0.629346262736044 0.234473861962652 no 803 0.264561195163228 1313 5212874 SGTC_117 lucigenin 22.078 µM 0.628875302885176 0.234629294945376 no 804 0.264715347932776 1265 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1491 4138-0063 26.5 µM 0.628394394190705 0.234788070172283 no 805 0.264872804239519 1262 23883227 SGTC_1085 doxorubicin 7.67 µM 0.625845338698117 0.235630648906188 no 806 0.265708195185087 1316 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2737 bleomycin 30.5 nM 0.625239872684616 0.235831027800879 no 807 0.26590681809728 1326 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2894 9048625 32.47 µM 0.623611425137915 0.236370428115511 no 808 0.266441402762386 1386 4092861 SGTC_213 1246-0773 967 nM 0.623506332572479 0.236405261862932 no 809 0.266475921081302 1305 6251622 SGTC_955 1216-0110 33 µM 0.623297660337366 0.236474436272003 no 810 0.266544467503292 1257 3619719 SGTC_1007 4101-0031 70 µM 0.622222515349205 0.236831021088749 no 811 0.266897781502593 1288 1146276 SGTC_2828 7998861 71.43 µM 0.621516904009543 0.237065206208852 no 812 0.267129787926764 1251 2988188 SGTC_2551 apiole 73.87 µM 0.621292616258399 0.237139671642567 no 813 0.267203555508139 1222 10659 A possible DNA adduct former. SGTC_592 k241-0073 46.5 µM 0.619548418911056 0.237719198275165 no 814 0.267777567527329 1334 4230158 SGTC_1024 4507-0395 26 µM 0.618764288241201 0.237979986295352 no 815 0.268035825720467 1344 4201836 SGTC_1997 st073024 93.8 µM 0.618306425818642 0.238132335752316 no 816 0.268186683452243 1301 686268 SGTC_2217 6934799 96.0675 µM 0.618041477829524 0.238220519133732 no 817 0.268273998733178 1260 675606 SGTC_1910 st062352 60.4 µM 0.617693485848394 0.238336369454993 no 818 0.268388703408877 1231 2245730 SGTC_2634 4'-methoxyflavone 100 µM 0.617470585097449 0.238410591752372 no 819 0.268462188628292 1319 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_671 0560-0003 407 µM 0.616919934586194 0.238594003591856 no 820 0.268643768712493 1264 3238678 SGTC_1284 0929-0043 16 µM 0.61679897079123 0.238634304812296 no 821 0.268683665466201 1303 1239883 SGTC_165 k038-0023 64.381 µM 0.613641458110426 0.239687602499886 no 822 0.269726140622799 1298 46368543 SGTC_3132 9126706 49.47 µM 0.613366819675719 0.239779337444836 no 823 0.26981691011592 1328 850858 SGTC_1501 4491-0275 38.4 µM 0.612510314708304 0.240065550889727 no 824 0.270100087845872 1309 5104718 SGTC_1725 st036284 20.55 µM 0.612031545059332 0.240225619768421 no 825 0.270258443455352 1359 707914 SGTC_549 1661-1316 519 µM 0.611814676313141 0.240298145456982 no 826 0.270330189220686 1355 2857282 SGTC_147 4466-0538 29.23 µM 0.610725776956659 0.240662477666583 no 827 0.270690569026419 1377 6742687 YHR072W ERG7 SGTC_162 k030-0015 37.8 µM 0.609194982176725 0.241175170654296 no 828 0.271197602952492 1375 1809920 YMR134W ERG29 SGTC_2938 9059746 27.26 µM 0.608032392967819 0.241564940742777 no 829 0.271582994951042 1323 6471769 SGTC_382 3229-0966 23.2 µM 0.606150531555206 0.242196578567564 no 830 0.272207399223377 1381 5722370 SGTC_935 2996-0153 430 µM 0.606129754947983 0.242203557130185 no 831 0.27221429691102 1337 23738523 SGTC_779 1360-0071 233 µM 0.60592245437947 0.242273192369395 no 832 0.272283124000357 1450 7566 SGTC_356 1634-0012 32.5 µM 0.6055594862686 0.242395144700093 no 833 0.27240365601307 1340 735457 SGTC_70 0141-0289 43.283 µM 0.605264529267251 0.242494270716277 no 834 0.272501622867612 1408 352408 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.604422173208528 0.242777481646374 no 835 0.272781498827811 1306 61125 An anti-inflammatory. SGTC_842 0271-0008 11.1 µM 0.60409023689758 0.24288913205136 no 836 0.27289182506832 1386 1221709 SGTC_642 0335-0876 158 µM 0.604027347401981 0.242910288750423 no 837 0.272912730250986 1358 6812350 SGTC_1779 st039427 55 µM 0.603397778935797 0.243122137257226 no 838 0.273122049718415 1455 1124498 SGTC_3305 9127027 53.8275 µM 0.602314198197219 0.243486993801942 no 839 0.27348250579132 1317 41905295 SGTC_598 3937-0236 20.2 µM 0.601900507202692 0.243626367231637 no 840 0.273620183310813 1360 1379313 SGTC_2101 5377231 179.231 µM 0.601787917957663 0.243664306258819 no 841 0.27365765926234 1399 2844213 SGTC_1091 telmisartan 47.6 µM 0.601058726374577 0.243910098057821 no 842 0.273900436170078 1388 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_802 4112-3352 742 µM 0.600918619102819 0.243957339946725 no 843 0.273947095650445 1428 704594 SGTC_2409 alverine citrate 63.97 µM 0.600349521077984 0.244149281266759 no 844 0.274136660941691 1457 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2328 6201408 200 µM 0.599646499467584 0.244386503766452 no 845 0.274370925315226 1318 2890418 SGTC_2798 7813637 45.45 µM 0.599274138123705 0.244512200969633 no 846 0.274495045442317 1355 956368 SGTC_790 1575-0012 79.1 µM 0.597725084064492 0.245035485360688 no 847 0.275011692645679 1376 378741 YLR208W SEC13 SGTC_2188 6126565 140.678 µM 0.597171107960175 0.245222769610875 no 848 0.275196573372574 1332 874518 SGTC_2944 9067346 25.62 µM 0.596798636032003 0.245348735493854 no 849 0.275320914357339 1327 6473075 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.595169373011482 0.245900142753855 no 850 0.275865130226014 1372 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1028 k015-0029 4.8 µM 0.594825928418628 0.246016462849208 no 851 0.275979916987407 1336 4588309 SGTC_2199 6590217 200 µM 0.594400210894522 0.246160688652242 no 852 0.276122233728975 1335 703109 SGTC_492 tmb-8 126 µM 0.59432774013448 0.246185245019791 no 853 0.276146464185348 1260 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1540 guanosine 70.6 µM 0.594195329117072 0.246230115247023 no 854 0.276190738244513 1303 6802 Guanosine is a purine nucleoside SGTC_3105 9121040 49.47 µM 0.59355828881228 0.246446050887541 no 855 0.276403793074452 1224 41448907 SGTC_918 glabranin 770.725 nM 0.592103195120814 0.246939660002332 no 856 0.276890743749928 1407 124049 Also referred to as licorice root. SGTC_43 0570-0105 72.5 µM 0.591637848552416 0.247097630360255 no 857 0.277046561731306 1393 1114046 YDL195W SEC31 SGTC_1558 st069300 45.6 µM 0.590138523106361 0.247606971102361 no 858 0.277548891877401 1344 24208000 SGTC_2842 9000675 19.48 µM 0.588918227243867 0.248021935404463 no 859 0.277958064935837 1300 2989072 SGTC_2934 9036370 36.88 µM 0.588096809901683 0.248301468991553 no 860 0.278233657129255 1386 6462800 SGTC_2827 7993847 71.43 µM 0.587896359571351 0.248369709010485 no 861 0.278300930061542 1370 2985692 SGTC_3237 9133362 49.47 µM 0.587723444216444 0.248428583230079 no 862 0.278358968378079 1377 43845137 SGTC_1932 st074806 40.9 µM 0.587594952797071 0.248472336804678 no 863 0.278402099806382 1443 17251235 SGTC_1971 st069429 63.5 µM 0.586999943830821 0.248675001284216 no 864 0.278601872219759 1348 1246522 YGL099W LSG1 SGTC_1451 4152-0210 104 µM 0.586780757628469 0.248749679917792 no 865 0.278675480898113 1441 659563 SGTC_1435 4092-0789 56.7 µM 0.586747202616294 0.248761113454365 no 866 0.278686750418033 1422 2248285 SGTC_2288 7946289 167.31 µM 0.586531652410769 0.248834566714263 no 867 0.278759148688552 1444 1246052 SGTC_2204 7233102 200 µM 0.585159752148256 0.249302341022255 no 868 0.279220152325642 1326 2172480 SGTC_2914 7968218 45.32 µM 0.585145724288779 0.249307126489163 no 869 0.279224868061249 1390 2977111 SGTC_1410 3909-8106 77.9 µM 0.584950103684736 0.249373865631697 no 870 0.279290633734863 1398 1039210 SGTC_1570 verbenone 133 µM 0.583117118822544 0.249999679274407 no 871 0.279907230170236 1401 29025 A natural terpanoid with antifungal properties. SGTC_1490 4089-0339 670 nM 0.579794544937337 0.251136186091063 no 872 0.281026588352288 1339 742542 SGTC_674 0498-0004 451 µM 0.579275101201729 0.251314111711441 no 873 0.281201781602844 1321 4231473 SGTC_761 k216-0224 480 µM 0.578871864263757 0.251452278827231 no 874 0.281337818035588 1441 1340404 SGTC_2685 mycophenolic acid 18.85 µM 0.577334176468048 0.251979528048471 no 875 0.281856865320058 1370 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3126 9127922 49.47 µM 0.575547050722337 0.252593037905327 no 876 0.282460689683748 1392 45595682 SGTC_1226 3909-7979 35.4 µM 0.57440656831797 0.252984969790259 no 877 0.282846354591723 1414 6615510 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.574147756660588 0.253073956103296 no 878 0.282933909396783 1373 756377 SGTC_1220 1838-0075 193 µM 0.572496738606261 0.253642007242676 no 879 0.283492747364398 1321 5529645 SGTC_2496 diffractaic acid 79.83 µM 0.572164744291717 0.253756314399554 no 880 0.283605184927037 1484 94870 An apoptosis inducer which activates caspases. SGTC_111 0083-0039 52.457 µM 0.569686397166453 0.254610474471964 no 881 0.284445208895947 1314 759313 SGTC_3069 9117009 49.47 µM 0.568709166397861 0.254947689665522 no 882 0.284776763066892 1299 41904981 SGTC_1521 st012942 49.4 µM 0.568093374464457 0.255160302327126 no 883 0.284985783202515 1513 24207259 SGTC_1073 triclabendazole 3.09 µM 0.568089025197633 0.255161804315327 no 884 0.284987259747583 1427 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2514 salinomycin 42.74 µM 0.568041079284567 0.255178362400028 no 885 0.285003537284912 1456 23682228 A polyether potassium ionophore. SGTC_518 1021-0119 62.6 µM 0.567858684769829 0.255241357341423 no 886 0.28506546389255 1333 1097762 SGTC_1475 4092-1048 11.7 µM 0.567294098622493 0.255436404156072 no 887 0.285257192900429 1372 2881759 SGTC_2908 7930301 100 µM 0.567130970864912 0.255492774181586 no 888 0.285312601240151 1310 2223178 SGTC_2229 7354935 190 µM 0.566909356047586 0.255569365262283 no 889 0.285387883638239 1359 318112 SGTC_932 2857-0803 154 µM 0.565318100236851 0.256119662469871 no 890 0.28592870975698 1518 674898 SGTC_1132 3456-3614 2.5 µM 0.563879543920088 0.256617683592471 no 891 0.286418056255746 1560 3125502 SGTC_3306 9127676 59.7925 µM 0.563776863858784 0.256653250197857 no 892 0.286452999609905 1387 41905287 SGTC_2766 oltipraz 83.91 µM 0.562972073506152 0.256932104597391 no 893 0.286726950228045 1448 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3119 9125183 49.47 µM 0.560385333399146 0.257829458968166 no 894 0.28760831669721 1304 22695334 SGTC_2995 9067767 71.4286 µM 0.559882056264189 0.258004237387008 no 895 0.287779944391731 1408 11673567 SGTC_2443 5493264 126.67 µM 0.559732987160956 0.258056017999078 no 896 0.287830789260793 1464 5340055 SGTC_650 1328-0195 38 µM 0.559145028042682 0.258260303891823 no 897 0.288031373213133 1383 2780821 SGTC_2711 st079103 59.1 µM 0.558808859212325 0.258377143116068 no 898 0.288146087819128 1429 54693780 SGTC_1748 st037455 53.6035 µM 0.558447803830361 0.258502662436101 no 899 0.288269318741869 1422 580690 SGTC_1319 1306-0155 43.7 µM 0.558381542361065 0.258525701374716 no 900 0.288291936979698 1431 3122360 SGTC_563 tetrahydrosecaminediol 614 µM 0.558239724312729 0.258575014710638 no 901 0.288340349137227 1468 334274 A psychoactive constituent of the cannabis plant. SGTC_3231 9132313 49.47 µM 0.557814975385606 0.258722738633951 no 902 0.288485367798805 1422 4905967 SGTC_1967 st070177 51.4 µM 0.557659235344673 0.258776914586882 no 903 0.28853854949814 1466 5729214 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.557345499213422 0.258886069108867 no 904 0.288645697310543 1517 6728940 SGTC_3073 9114972 49.47 µM 0.556137644741794 0.259306525985151 no 905 0.289058381132953 1414 41905075 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.555696601826827 0.259460141920755 no 906 0.289209140010154 1464 551469 SGTC_3265 9137266 49.47 µM 0.554876283816865 0.259745984926542 no 907 0.289489642334878 1396 17224265 SGTC_1169 aniline yellow 25.8 µM 0.55443910333131 0.259898388526662 no 908 0.289639185488327 1417 6051 A DNA damaging agent. SGTC_1830 st055982 50.3 µM 0.554311106445903 0.259943017695689 no 909 0.289682975314828 1401 455313 An antimicrobial agent. SGTC_1183 1254-0324 198 µM 0.554253230820786 0.259963198711331 no 910 0.289702776532195 1465 5799357 SGTC_3178 9107506 49.47 µM 0.552929396166007 0.260425035473191 no 911 0.290155878679391 1423 8897194 SGTC_1626 st003712 1.76 µM 0.552687632864847 0.260509423323212 no 912 0.290238661618552 1418 24207035 SGTC_1977 st070720 65.3 µM 0.548736470737212 0.261890575213933 no 913 0.291593156869979 1406 682188 SGTC_749 1000-0129 128 µM 0.548527823986082 0.261963613153903 no 914 0.291664764775843 1518 708470 SGTC_652 0437-0092 114 µM 0.546370999865408 0.262719232757242 no 915 0.292405470198477 1382 3091274 SGTC_154 3389-1638 511.116 µM 0.545877613863072 0.262892241684177 no 916 0.292575033685989 1300 5238686 SGTC_869 0564-0080 44.1 µM 0.54552026363407 0.263017585170829 no 917 0.292697873862401 1391 6843321 SGTC_831 k061-1017 217 µM 0.54478563476738 0.263275358101381 no 918 0.292950479874472 1494 1240153 SGTC_1010 4112-3296 15.2 µM 0.54264859295372 0.264025954705025 no 919 0.293685887548846 1473 704384 SGTC_3096 9117468 49.47 µM 0.542072941771375 0.264228327856804 no 920 0.293884129001798 1348 41316311 SGTC_2148 5546263 113.568 µM 0.539494755793426 0.265135670639116 no 921 0.294772757274011 1435 792097 SGTC_219 mitoxanthrone 164.414 µM 0.539491833028343 0.265136700147131 no 922 0.294773765371695 1454 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2932 9016711 44.54 µM 0.539084609118823 0.265280159600243 no 923 0.294914237451617 1502 7117328 SGTC_2093 5331342 194.4 µM 0.538400343903135 0.265521305649257 no 924 0.295150344502982 1464 33839 SGTC_1400 3771-8998 51.5 µM 0.538092381949848 0.265629872661356 no 925 0.295256635771018 1438 670767 SGTC_2744 captopril 92.04 µM 0.537084565705467 0.265985319310369 no 926 0.2956046007668 1510 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2420 aureobasidin a 50 nM 0.537006842288125 0.26601274158184 no 927 0.295631443872472 1570 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_659 k018-0002 107 µM 0.536643905759299 0.266140811313287 no 928 0.295756805012125 1450 6797879 YHR007C ERG11 SGTC_2920 7982904 15.77 µM 0.536062312816687 0.266346103604938 no 929 0.29595774271409 1402 6456808 SGTC_3027 9089541 49.47 µM 0.535801133044124 0.266438321632344 no 930 0.296047999520615 1416 9943819 SGTC_208 k072-0098 12.366 µM 0.534339350448772 0.266954749611415 no 931 0.29655338590136 1417 5948901 SGTC_445 e6 berbamine 66 µM 0.533729094002136 0.267170494438651 no 932 0.29676448853986 1443 6610268 A calcium/calmodulin antagonist. SGTC_1658 st012944 20 µM 0.533382185544224 0.267293176701572 no 933 0.296884523326319 1397 24207260 SGTC_2664 lyso-paf C-16 73.48 µM 0.532894013261118 0.267465864268339 no 934 0.297053474832129 1445 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_378 3970-0959 8.33 µM 0.532268980185023 0.267687047500032 no 935 0.297269856645106 1431 6615653 SGTC_823 0417-1665 178 µM 0.531942696969315 0.267802547401028 no 936 0.297382842080032 1471 3429856 SGTC_913 3487-1245 167 µM 0.531714538733849 0.267883327283176 no 937 0.297461860424131 1371 4016153 SGTC_2412 st077135 33.4 µM 0.53086822892934 0.268183072123667 no 938 0.297755047728802 1513 13258915 SGTC_2716 st080858 38.6235 µM 0.529666315009286 0.268609054190845 no 939 0.298171653437694 1415 5296050 SGTC_773 4358-1457 44.6 µM 0.529471480110772 0.268678139548182 no 940 0.298239211835915 1543 1186886 SGTC_1970 st070122 35.8 µM 0.529341072498362 0.268724385001277 no 941 0.298284434165796 1481 102928 SGTC_236 1509-0011 5.31 µM 0.526247144571578 0.26982273249528 no 942 0.299358250881676 1465 3107280 SGTC_3283 9109332 35.8195 µM 0.526225465768126 0.269830436414682 no 943 0.299365781175986 1392 17027281 SGTC_946 3434-1334 87.4 µM 0.525837727557579 0.269968244162641 no 944 0.299500479445819 1497 4047976 SGTC_632 0781-2353 4.65 µM 0.525094710105614 0.270232421656449 no 945 0.299758676639489 1472 6811515 YHR007C ERG11 SGTC_3330 9141424 71.43 µM 0.523167173491655 0.270918353277888 no 946 0.300428961531032 1523 27261020 SGTC_2707 st078556 66.6 µM 0.522823177962513 0.27104085854619 no 947 0.300548654293511 1483 17250899 SGTC_1652 st011932 78 µM 0.522734608580511 0.271072404753866 no 948 0.300579475371408 1496 1551076 SGTC_2097 5376186 200 µM 0.522025818934377 0.271324923917715 no 949 0.300826177018324 1501 742755 SGTC_2432 5630864 12.22 µM 0.521002819042349 0.271689592766505 no 950 0.3011824037814 1415 5714970 SGTC_768 0384-0033 77.3 µM 0.520259930488522 0.271954563139732 no 951 0.301441209840452 1420 3965305 YMR134W ERG29 SGTC_1735 st034310 56.75 µM 0.519669239678473 0.272165339952243 no 952 0.30164706495374 1553 871153 SGTC_490 phenamil 164 µM 0.51937477494417 0.272270444428742 no 953 0.301749709206617 1509 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_450 aminopyrene 156 nM 0.518099020713436 0.272726037337758 no 954 0.302194591736201 1500 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_943 3253-1379 105 µM 0.5167862302498 0.273195251062459 no 955 0.30265269666245 1537 668464 SGTC_83 0170-0301 39.027 µM 0.516330165048134 0.273358350111534 no 956 0.302811915733628 1457 3089716 SGTC_1277 0873-0036 22 µM 0.515685192110266 0.273589089048565 no 957 0.303037149280738 1556 5965735 SGTC_3251 9135047 49.47 µM 0.511862421794325 0.274958659619892 no 958 0.304373649779315 1542 17682963 SGTC_2978 9011784 42.97 µM 0.511322375370766 0.275152412139684 no 959 0.30456266984406 1633 2994934 SGTC_603 3794-0023 45.9 µM 0.51124972401805 0.275178482403702 no 960 0.304588102315579 1540 3802260 SGTC_427 1354-0053 47.3 µM 0.511202828041714 0.275195311235692 no 961 0.304604519312461 1547 6813657 SGTC_2783 7738165 71.43 µM 0.511052259844073 0.275249346735439 no 962 0.304657231774823 1374 17201110 SGTC_2298 7976326 193.81 µM 0.509425949541562 0.275833325143958 no 963 0.305226845538267 1399 2235818 SGTC_1729 st035615 45.989 µM 0.508645426991206 0.276113812612017 no 964 0.305500390612564 1446 17385451 SGTC_2467 5474540 200 µM 0.507644065749226 0.27647386527924 no 965 0.305851490755219 1436 5413519 SGTC_3034 9090421 49.47 µM 0.507491289383696 0.276528818275461 no 966 0.305905073344118 1450 17173761 SGTC_1976 st070609 63.5 µM 0.506840755349363 0.276762872475991 no 967 0.30613327880866 1435 682556 SGTC_2438 5259590 200 µM 0.506064748603657 0.277042197097612 no 968 0.306405598160765 1547 1201127 SGTC_3244 9134489 49.47 µM 0.504730767861101 0.277522687409573 no 969 0.306873973862376 1423 16584271 SGTC_112 phenothiazine 287.218 µM 0.50191449152192 0.278538425497024 no 970 0.307863835555581 1541 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3025 9087895 49.47 µM 0.500805905008559 0.27893875224492 no 971 0.308253864703935 1519 17173641 SGTC_96 0929-0093 37.281 µM 0.499408683026665 0.279443707829904 no 972 0.308745751695742 1444 6991579 SGTC_834 0312-0008 75.7 µM 0.496689538850449 0.2804276765369 no 973 0.309704000297761 1503 6385573 YIL048W NEO1 SGTC_2251 lansoprazole 556 µM 0.496626650235736 0.280450453686173 no 974 0.309726178101927 1416 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1339 1486-1321 22.7 µM 0.496354856675553 0.280548902827369 no 975 0.309822034645741 1483 3469382 SGTC_2520 obtusaquinone 4.71 µM 0.496034230287359 0.280665061706996 no 976 0.309935130247766 1569 5967872 SGTC_1218 1348-1416 30.7 µM 0.495551804968816 0.280839882116851 no 977 0.310105331611712 1487 6787668 SGTC_1081 sertraline 6 µM 0.493017693645354 0.281759052362297 no 978 0.311000042691004 1560 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2437 5741531 144.16 µM 0.492662682965146 0.281887937182152 no 979 0.311125474669965 1608 2262990 SGTC_911 3456-4043 236 µM 0.492456928745435 0.281962648204069 no 980 0.311198181565743 1587 914281 SGTC_895 0964-0006 13.7 µM 0.491118651136301 0.282448820267967 no 981 0.311671265344487 1473 6738897 SGTC_813 k007-0158 173 µM 0.49098646881039 0.282496861585055 no 982 0.311718008946187 1597 6523916 SGTC_328 k915-0120 63.5 µM 0.490948833554782 0.282510540737847 no 983 0.31173131844677 1564 6624543 SGTC_1832 st054113 55 µM 0.490942924353423 0.282512688563222 no 984 0.311733408225578 1507 1251267 SGTC_3084 9116877 49.47 µM 0.490532372606543 0.282661931578403 no 985 0.31187861397828 1459 27241325 SGTC_1217 1183-1422 255 µM 0.490530345627799 0.282662668515971 no 986 0.311879330961631 1583 2849664 SGTC_432 NS 1619 61.3 µM 0.490080201495002 0.282826347821555 no 987 0.312038573693925 1506 4552 A K+/calcium channel activator. SGTC_2645 abamectin 100 µM 0.488794851367309 0.283293971255289 no 988 0.312493471731882 1525 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2128 5255449 168.493 µM 0.48750649658767 0.283763059588483 no 989 0.312949720038163 1451 736008 SGTC_3235 9132602 49.47 µM 0.486325258326075 0.284193473494931 no 990 0.313368286810199 1522 4912240 SGTC_1968 st069590 43.6 µM 0.485924423391098 0.284339598700617 no 991 0.313510375649423 1549 6384066 SGTC_2186 6124449 200 µM 0.485848885013923 0.284367140393 no 992 0.313537155757616 1538 3834182 YLR033W RSC58 SGTC_1280 0880-0253 10.1 µM 0.485763056420433 0.284398435499829 no 993 0.313567585179163 1484 6836607 SGTC_3004 9076122 71.4286 µM 0.485073184108171 0.284650038788332 no 994 0.313812216582539 1575 44782551 SGTC_2790 5423970 71.43 µM 0.48472765544528 0.28477609645523 no 995 0.313934773169147 1613 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_766 1391-0721 126 µM 0.484505123287871 0.284857295961844 no 996 0.314013714628872 1611 1020919 YIL115C NUP159 SGTC_881 0833-0569 170 µM 0.484440192382485 0.284880990607835 no 997 0.314036749939861 1449 5418700 SGTC_733 4069-0007 56.1 µM 0.483828349621269 0.285104310993888 no 998 0.314253846836476 1529 5717425 YNL287W SEC21 SGTC_2469 5655019 90.81 µM 0.482393360716672 0.285628403865483 no 999 0.314763268326203 1624 2788239 SGTC_366 0181-0206 4.31 µM 0.481759177636236 0.285860168944495 no 1000 0.314988515955672 1663 274874 SGTC_1895 st058434 18.3 µM 0.479512510527888 0.286681942310664 no 1001 0.315787035153389 1597 5393175 SGTC_703 3875-0075 71.8 µM 0.479427789005949 0.286712953181192 no 1002 0.315817164067723 1568 2850814 SGTC_959 1222-0044 107 µM 0.478458662662731 0.287067798478042 no 1003 0.316161894624967 1563 6083612 SGTC_2320 7373003 200 µM 0.478418345342949 0.287082565156404 no 1004 0.316176239473831 1438 5415828 SGTC_11 0438-0307 1.3 µM 0.478253314418382 0.287143013364561 no 1005 0.316234960141863 1603 4011476 SGTC_2213 7173844 200 µM 0.477071118077968 0.28757620921303 no 1006 0.31665574013617 1490 892728 SGTC_1998 st075797 76.8 µM 0.476655014503992 0.2877287568028 no 1007 0.316803900684882 1530 24208315 SGTC_2780 5215298 71.43 µM 0.476134313074269 0.287919704817849 no 1008 0.316989346423701 1600 2834131 SGTC_1232 0279-0259 161 µM 0.475868695100932 0.288017133438869 no 1009 0.317083962919456 1500 1560000 SGTC_2309 7664088 163.95 µM 0.47492426677544 0.288363675540415 no 1010 0.317420477113248 1589 704922 SGTC_896 0964-0007 44.5 µM 0.472778377315746 0.289151803541765 no 1011 0.31818565106221 1521 6756758 SGTC_1874 staurosporine 7.6 µM 0.472533259699683 0.289241893123113 no 1012 0.318273103743723 1586 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1805 st050013 60.3 µM 0.472264148446153 0.289340816424792 no 1013 0.318369128503508 1550 4037144 SGTC_3313 9133968 57.047 µM 0.472041417181718 0.289422702808363 no 1014 0.318448613103537 1501 1494643 SGTC_443 clozapine 122 µM 0.465967503187868 0.291659941153407 no 1015 0.320619380801179 1547 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1101 ebselen 5.29 µM 0.465956307835153 0.291664072232548 no 1016 0.320623387629453 1654 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2243 6634756 200 µM 0.465488786641021 0.291836611648857 no 1017 0.320790732603881 1626 885676 SGTC_687 k029-0044 34.9 µM 0.464733002032545 0.292115635640932 no 1018 0.321061335874522 1648 5829338 SGTC_1353 1498-1206 8.11 µM 0.460998829159023 0.293496053237873 no 1019 0.322399722561333 1525 6756808 SGTC_2030 5175110 200 µM 0.46054120870846 0.2936654301198 no 1020 0.322563899884862 1595 2831986 SGTC_1607 st000305 50.6 µM 0.460148394757717 0.29381085655759 no 1021 0.322704854630436 1573 5457690 SGTC_2382 9035899 200 µM 0.459467135473859 0.294063149354256 no 1022 0.32294937358622 1543 6462679 SGTC_372 0155-0182 15.9 µM 0.457701183793426 0.294717605315263 no 1023 0.323583568706774 1591 771486 SGTC_487 nimodipine 119 µM 0.457274006597701 0.294876016632025 no 1024 0.323737055252982 1593 4497 L-type voltage-gated calcium channels inhibitor SGTC_1194 1488-0194 225 µM 0.455486418376394 0.295539338304325 no 1025 0.324379668165164 1552 1391452 SGTC_1066 ketoconazole 628 nM 0.454613544539175 0.295863485352502 no 1026 0.324693644378035 1621 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2622 2-methoxyxanthone 59.94 µM 0.45204367774715 0.296818767856355 no 1027 0.325618758567514 1695 71034 A hepatoprotective. SGTC_3157 9099274 49.47 µM 0.450897496885363 0.29724528615626 no 1028 0.326031713837711 1598 17217662 SGTC_1260 0700-1617 7.75 µM 0.45011894236225 0.297535162521883 no 1029 0.326312339507038 1579 2853078 SGTC_2876 9059903 25.97 µM 0.449476972083663 0.297774282011982 no 1030 0.326543808137671 1536 6916095 SGTC_1994 st072947 40.9 µM 0.448690661773781 0.298067284294579 no 1031 0.326827410980793 1596 5286565 YDL195W SEC31 SGTC_2032 5185112 25.99 µM 0.448550893944116 0.298119379635023 no 1032 0.326877832288185 1563 5718189 SGTC_2277 7947813 106.88 µM 0.447821505765294 0.298391310087493 no 1033 0.327141010676743 1662 1246798 SGTC_3205 9113483 49.47 µM 0.447228700020415 0.29861240301103 no 1034 0.327354970629585 1677 17018033 SGTC_1773 st048542 73.5835 µM 0.446687611930497 0.298814272318273 no 1035 0.327550313779263 1473 3237138 SGTC_199 4063-0024 41.6 µM 0.445903082019833 0.299107075063544 no 1036 0.327833627935988 1629 306215 SGTC_37 0566-0070 1.56 µM 0.445364695870248 0.299308087206906 no 1037 0.328028110541742 1660 1626686 SGTC_2329 6138490 200 µM 0.443994285424423 0.299820020676767 no 1038 0.328523357750117 1582 720019 SGTC_1334 1486-0610 236 µM 0.443962488762059 0.299831903410907 no 1039 0.328534852201032 1583 3742339 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.443859082039754 0.299870549022479 no 1040 0.328572234714708 1542 3256 An antibiotic and ribosome inhibitor. SGTC_1390 3413-2614 145 µM 0.443418713804865 0.30003515060306 no 1041 0.328731451228649 1578 3421432 SGTC_1137 ixabepilone 100 µM 0.442190348480444 0.300494506946586 no 1042 0.329175734807549 1517 154225 A novel microtubule stabilizer. SGTC_2555 cholic acid 100 µM 0.441014215147109 0.300934628170068 no 1043 0.329601352979115 1592 6708657 Influences liver metabolism. SGTC_2564 betulinic acid 100 µM 0.440691240493393 0.301055539467777 no 1044 0.32971826944911 1769 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2658 polymyxin b sulfate 77.05 µM 0.440571913815497 0.301100217067574 no 1045 0.329761469786159 1549 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2519 cryptotanshinone 88.04 µM 0.440566237199282 0.301102342547607 no 1046 0.329763524971903 1631 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2778 tioconazole 65.09 nM 0.437073491454714 0.302411401558035 no 1047 0.331029025594392 1521 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1807 st050092 58.9 µM 0.436578808669164 0.302597011698657 no 1048 0.331208416927088 1539 5008496 SGTC_2648 atorvastatin 78.68 µM 0.435819268454499 0.302882098436749 no 1049 0.331483931332704 1650 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_333 3486-0131 40.1 µM 0.433488495846854 0.303757683073622 no 1050 0.332329960949841 1694 6744690 SGTC_447 ml7 120 µM 0.433393501107854 0.303793393010022 no 1051 0.332364460539431 1649 4216 Selective myosin light chain kinase inhibitor. SGTC_1354 1498-1681 81 µM 0.433222405224564 0.30385771522361 no 1052 0.332426601644978 1601 5754243 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.433081236080427 0.30391079127754 no 1053 0.332477876987882 1553 803109 SGTC_511 blebbistatin 171 µM 0.433080120766205 0.303911210624147 no 1054 0.332478282103899 1658 3476986 A myosin inhibitor. SGTC_1273 0849-0096 14.1 µM 0.433038789711674 0.303926750854947 no 1055 0.332493294936828 1552 5286025 SGTC_2819 7996655 46.38 µM 0.431783120787413 0.304399043712093 no 1056 0.332949524227345 1642 6456960 SGTC_1422 4031-0024 15.5 µM 0.430342267206368 0.304941391940562 no 1057 0.333473342520219 1580 782427 SGTC_2206 7254556 146.969 µM 0.429681845790453 0.305190122962809 no 1058 0.333713545522304 1639 4398905 SGTC_1119 parthenolide 318.541 nM 0.428328701113802 0.305700031698398 no 1059 0.334205912926813 1676 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_59 0330-0160 1.33 µM 0.423440497233143 0.307545200548572 no 1060 0.335986951633709 1634 4293482 SGTC_1432 4049-0298 68.4 µM 0.423227826270109 0.307625589367111 no 1061 0.336064523262799 1702 741646 SGTC_1123 mangostin 811.285 nM 0.421767250540885 0.308177930889487 no 1062 0.336597456032654 1567 5281650 An antioxidant. SGTC_1009 4106-0057 9.87 µM 0.421176273229696 0.308401542590437 no 1063 0.3368131843569 1611 2928005 SGTC_2035 5154463 94.595 µM 0.420038521424694 0.308832240857845 no 1064 0.337228656523538 1671 2769623 SGTC_3029 9088683 49.47 µM 0.418430169630091 0.30944153436581 no 1065 0.337816316120347 1606 25236615 SGTC_2870 9038528 12.99 µM 0.417782425931632 0.309687067930541 no 1066 0.338053100539959 1575 6463316 SGTC_3197 9113331 49.47 µM 0.41730427601314 0.309868369824142 no 1067 0.338227930624067 1708 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_693 4161-2696 114 µM 0.417039620319035 0.309968740202357 no 1068 0.338324713972667 1693 805759 SGTC_474 dl-dihydrosphingosine 5 µM 0.417002166217916 0.309982945772891 no 1069 0.338338411625159 1657 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3213 9129884 49.47 µM 0.415848060374206 0.310420813348028 no 1070 0.338760594108386 1469 17190742 SGTC_2219 9098279 200 µM 0.415070613599995 0.310715928105867 no 1071 0.339045105530195 1685 902349 SGTC_1135 dihydrocapsaicin 536.708 nM 0.414385194840388 0.310976210568899 no 1072 0.339296014903823 1516 107982 A Capsaicinoid. SGTC_3338 9144300 39.5675 µM 0.413157362315787 0.311442706882007 no 1073 0.33974566233888 1662 4901274 SGTC_2036 5160441 105 µM 0.412949594172461 0.311521675215341 no 1074 0.339821772184948 1636 134534 YIL048W NEO1 SGTC_1916 st067606 49.2 µM 0.412210812796102 0.311802540803975 no 1075 0.340092456235556 1709 19590279 SGTC_1778 st046819 58.9 µM 0.41168057164284 0.312004192294517 no 1076 0.340286783513933 1599 671715 SGTC_2663 amphotericin b 100 µM 0.411599154127667 0.312035160487597 no 1077 0.340316625854282 1615 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1285 0929-0069 65.5 µM 0.409106809788286 0.312983797478039 no 1078 0.341230639512727 1622 1206237 SGTC_314 1671-0008 2.74 µM 0.407124986996277 0.313739004680548 no 1079 0.341958096111602 1595 3913060 SGTC_3174 9107204 49.47 µM 0.406958366201691 0.313802534001675 no 1080 0.342019283466078 1664 3938802 SGTC_1211 1056-0033 32.3 µM 0.406136572209718 0.314115949062694 no 1081 0.342321127598568 1683 6741922 SGTC_2699 st077704 54.6 µM 0.40584520794042 0.314227101521747 no 1082 0.342428169614677 1621 645852 SGTC_778 3456-2434 196 µM 0.4056307671646 0.314308919227468 no 1083 0.342506959403481 1783 5539063 SGTC_108 0509-0257 621.132 µM 0.404839489116587 0.314610902273911 no 1084 0.342797749913479 1628 536624 SGTC_3263 9137018 49.47 µM 0.404538907091798 0.314725648804992 no 1085 0.34290823664841 1529 43844957 SGTC_2191 5911152 200 µM 0.40403500219502 0.314918053535386 no 1086 0.343093490126755 1623 2875902 SGTC_2127 5253358 187.912 µM 0.403236752854387 0.315222949880765 no 1087 0.343387032349787 1576 20612 SGTC_1 0258-0098 57.368 µM 0.403036509856957 0.315299453711487 no 1088 0.343460683039664 1606 6790032 YDR047W HEM12 SGTC_1855 st056195 39.6 µM 0.400283404174212 0.316352093285028 no 1089 0.344473895011588 1715 4028379 SGTC_3225 9130819 49.47 µM 0.399894383221737 0.316500954298531 no 1090 0.344617154716968 1663 4547121 SGTC_3181 9108277 49.47 µM 0.399296696837156 0.316729720215295 no 1091 0.344837300358077 1585 17097298 SGTC_2337 9009472 200 µM 0.39842988428759 0.317061619377281 no 1092 0.34515666650028 1721 5742383 SGTC_2386 9075165 157.42 µM 0.39817479975714 0.317159318304523 no 1093 0.345250670193294 1642 16452277 SGTC_1448 4255-0083 152 µM 0.398016727494435 0.317219867339502 no 1094 0.345308927739623 1772 5399660 SGTC_3162 9099653 49.47 µM 0.397261653163322 0.31750916344298 no 1095 0.345587261001697 1665 25237511 SGTC_1557 sumaresinolic acid 42.3 µM 0.395141341329967 0.318322126751421 no 1096 0.346369290095123 1578 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1196 1588-0294 184 µM 0.395122079287991 0.318329516162873 no 1097 0.346376397472806 1599 6144269 SGTC_2893 9048488 25.97 µM 0.394005081704566 0.31875814853283 no 1098 0.346788643716216 1565 6467338 SGTC_3080 9117754 49.47 µM 0.393984865947719 0.318765908286381 no 1099 0.346796106345398 1758 9550191 SGTC_3075 9116269 49.47 µM 0.392552997545852 0.319315728354034 no 1100 0.347324830375444 1647 17015205 YNL244C SUI1 SGTC_1180 1193-0155 285 µM 0.392297835724202 0.319413749164613 no 1101 0.347419081291837 1603 2921347 SGTC_1146 3579-1023 7 µM 0.389944997267761 0.32031818973075 no 1102 0.348288609714934 1757 X1146 SGTC_1376 2910-0861 41.3 µM 0.389820987450938 0.320365889288551 no 1103 0.34833446166929 1669 1112859 SGTC_2583 asiatic acid 100 µM 0.388993707867011 0.320684172830738 no 1104 0.348640400477668 1673 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_701 4424-0219 185 µM 0.388179762731932 0.320997454856525 no 1105 0.348941504134415 1749 2911779 SGTC_570 0987-0065 62.6 µM 0.388148743121008 0.321009396619728 no 1106 0.34895298113792 1703 3104428 SGTC_2499 avocadenofuran 51.48 µM 0.387566083636609 0.321233740126689 no 1107 0.349168586068772 1564 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_104 0074-0074 590.992 µM 0.386168982898061 0.32177193660455 no 1108 0.349685761747434 1700 3943124 SGTC_3288 9119690 36.221 µM 0.385662824400672 0.321967013308478 no 1109 0.349873199306485 1591 17595618 YKL019W RAM2 SGTC_470 aa-861 153 µM 0.384992094815968 0.322225592347242 no 1110 0.350121636203464 1617 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_417 st075190 100 µM 0.384344308067349 0.32247540818543 no 1111 0.350361636027426 1761 222757 SGTC_38 0929-0051 58.268 µM 0.383837840056888 0.322670780989657 no 1112 0.350549320017519 1807 1379719 SGTC_2216 7189485 200 µM 0.383732218573236 0.322711531226841 no 1113 0.350588465216608 1726 731273 SGTC_1716 st033144 30.6155 µM 0.382519369939027 0.323179617597618 no 1114 0.351038082096555 1772 674617 SGTC_453 enantio-paf c16 10 µM 0.382236628102438 0.323288779169221 no 1115 0.351142927743549 1649 13871343 A lipid and platelet activating factor SGTC_1954 st077032 68.9 µM 0.38116941965377 0.323700946325216 no 1116 0.351538769457393 1571 698907 SGTC_1114 scopoletin 1.73284 µM 0.380111584220034 0.324109707035854 no 1117 0.351931293537808 1779 5280460 A coumarin with genotoxic properties. SGTC_587 k089-0003 57 µM 0.378335134879643 0.324796626126012 no 1118 0.352590823943022 1716 9659696 SGTC_1691 st019933 84.6 µM 0.377770583615841 0.325015052295039 no 1119 0.352800514030221 1766 6176082 SGTC_1524 corynanthine 62.1 µM 0.377433704733836 0.325145420165566 no 1120 0.352925661554828 1696 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_264 promethazine 12.5 mM 0.37682377175197 0.325381510981295 no 1121 0.353152286742283 1646 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2408 sulbentine 18.36 µM 0.376589863706603 0.325472069923766 no 1122 0.353239210859415 1721 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3065 9113888 49.47 µM 0.376242200081468 0.325606689079267 no 1123 0.353368422588009 1733 16648368 SGTC_3214 9129694 49.47 µM 0.375538301932832 0.325879315777169 no 1124 0.353630083223332 1775 17158655 SGTC_714 4296-0578 26.1 µM 0.375361221786726 0.325947915331208 no 1125 0.353695920265893 1764 1589775 SGTC_1094 duloxetine 25.4 µM 0.375275915488382 0.325980964470564 no 1126 0.353727638056517 1664 60834 A selective serotonin reuptake inhibitor. SGTC_2708 st078559 56 µM 0.375021213679655 0.326079648502207 no 1127 0.353822344943814 1647 17250902 SGTC_1282 0886-0010 32.4 µM 0.374617118605084 0.326236239839138 no 1128 0.353972619942573 1789 2836211 YNL267W PIK1 SGTC_3076 9116187 49.47 µM 0.374065543848726 0.32645003064191 no 1129 0.354177776446207 1800 27241210 SGTC_1942 st076330 65.2 µM 0.372875208650875 0.326911599728544 no 1130 0.354620662082929 1703 24208414 SGTC_3240 9133527 49.47 µM 0.372837634352981 0.326926174004292 no 1131 0.354634645480823 1651 17617455 SGTC_541 4513-1321 94 µM 0.372549966873284 0.327037762884211 no 1132 0.354741708364315 1624 747515 SGTC_72 0744-0168 198.391 µM 0.371965113130424 0.327264680745087 no 1133 0.354959412163649 1715 677577 SGTC_2593 nobiletin 86.24 µM 0.371098535368136 0.327601022311196 no 1134 0.355282070938342 1621 72344 An anti-infammatory. SGTC_283 0987-0079 11.7 µM 0.3686927978142 0.328535485046398 no 1135 0.356178358828474 1766 411556 SGTC_1318 1280-3875 124 µM 0.368290662903197 0.328691791528606 no 1136 0.356328256971227 1690 373245 SGTC_786 4544-0069 423 µM 0.367780208392763 0.328890244105831 no 1137 0.356518563854108 1751 748821 YLR208W SEC13 SGTC_2667 digitoxin 100 µM 0.365491988369258 0.32978044189953 no 1138 0.357372093072816 1772 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2426 5582046 32.21 µM 0.364171194933132 0.330294716495776 no 1139 0.357865087702882 1710 2251934 SGTC_3149 9097855 49.47 µM 0.360203487528364 0.331841540212866 no 1140 0.359347483424414 1820 25236625 YMR079W SEC14 SGTC_1500 4488-1866 171 µM 0.359769855362068 0.332010767626352 no 1141 0.359509623867096 1777 2900003 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.3581891168939 0.332627949744282 no 1142 0.360100895567735 1841 5024745 SGTC_3068 9116768 49.47 µM 0.356062444850339 0.333459001663451 no 1143 0.360896900599142 1681 41904888 SGTC_2122 5258151 111.688 µM 0.355697799473477 0.333601578512907 no 1144 0.36103344658387 1658 2173356 SGTC_851 0394-0702 453 µM 0.351940434677188 0.335072110015741 no 1145 0.362441467098994 1819 762646 SGTC_1619 st003326 88.7 µM 0.349123026914647 0.336176430107862 no 1146 0.363498474975483 1799 2849032 SGTC_1772 st048439 82.2 µM 0.345715759959199 0.337513843666814 no 1147 0.36477816952285 1703 2927068 YDL195W SEC31 SGTC_1656 st012921 11 µM 0.343736524636109 0.338291673924475 no 1148 0.365522220176226 1788 6732821 SGTC_2175 5807670 165.306 µM 0.343053800866064 0.338560141553354 no 1149 0.365778992982667 1796 241186 SGTC_1426 4048-4480 71.7 µM 0.342554008733702 0.338756726966337 no 1150 0.365967003231373 1790 14224343 SGTC_1109 tnp00067 928.257 nM 0.34215320966743 0.338914406750336 no 1151 0.366117797837136 1687 676295 SGTC_529 4076-0302 30.3 µM 0.340943955622607 0.339390314646167 no 1152 0.366572886677036 1692 5816522 SGTC_764 1951-2361 146 µM 0.340879663268852 0.339415624400628 no 1153 0.366597087623555 1651 5438930 SGTC_2160 5660466 132.927 µM 0.340800652780539 0.339446729185671 no 1154 0.366626829500981 1831 2859134 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.338659894825914 0.340289916741446 no 1155 0.367432978185922 1748 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1059 3448-6867 171 µM 0.338540207825479 0.340337081891169 no 1156 0.36747806620119 1872 3934407 SGTC_2606 farnesol 9.78 µM 0.338100880776319 0.340510229250469 no 1157 0.367643583412747 1817 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3260 9137109 49.47 µM 0.337232180761323 0.340852699808368 no 1158 0.367970939966221 1828 17478346 SGTC_102 gallobenzophenone 83.616 µM 0.336268961855358 0.341232586257402 no 1159 0.368334026670872 1813 70837 SGTC_3116 9124943 49.47 µM 0.336135623072402 0.341285186784161 no 1160 0.368384298185403 1617 41905195 YPL160W CDC60 SGTC_3044 9093193 49.47 µM 0.334381516634679 0.34197744721174 no 1161 0.369045842553074 1666 25236277 SGTC_2568 diosmetin 100 µM 0.334111534635804 0.342084043227032 no 1162 0.36914769817916 1834 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3012 9080433 71.4286 µM 0.33357015316374 0.342297832832195 no 1163 0.369351971878029 1851 17688859 SGTC_683 panaxydol 45 µM 0.33188929906292 0.342961917948781 no 1164 0.369986425482667 1807 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1185 1319-0113 81.3 µM 0.330077515938974 0.343678275159815 no 1165 0.370670695859753 1786 4672763 SGTC_1434 4073-0095 163 µM 0.329647383748844 0.343848426846035 no 1166 0.370833207466014 1799 24133745 SGTC_1427 4048-4900 550 nM 0.329016227628481 0.344098156830566 no 1167 0.371071711203783 1850 24132586 SGTC_442 cape 100 µM 0.327912093606016 0.344535193817695 no 1168 0.371489064746017 1851 5281787 SGTC_3009 9080819 71.4286 µM 0.327662165854709 0.344634148752982 no 1169 0.371583556365192 1716 17027216 SGTC_2774 tamoxifen 10.92 µM 0.327205048656353 0.344815164571261 no 1170 0.371756401303982 1734 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1811 st050069 61.5 µM 0.326916222874619 0.344929556262389 no 1171 0.37186562530284 1846 3877702 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.326787100855015 0.344980700625498 no 1172 0.371914458156029 1776 2724278 An inhibitor of dopamine biosynthesis. SGTC_2985 9022375 71.43 µM 0.326174108459717 0.345223541413814 no 1173 0.372146314782283 1740 4939335 SGTC_889 0919-1524 82.7 µM 0.326150667355431 0.345232829020515 no 1174 0.372155182004577 1722 3905452 SGTC_1201 1889-3372 45.9 µM 0.32587365668436 0.345342590556269 no 1175 0.37225997380496 1740 5392199 SGTC_1804 st050076 49.1 µM 0.325431895286624 0.34551765913355 no 1176 0.372427109580031 1780 3895976 SGTC_575 k072-0246 11.9 µM 0.32389743640345 0.346126016666761 no 1177 0.373007842456011 1758 6796779 SGTC_1814 st052110 31.539 µM 0.323701807300743 0.346203605129688 no 1178 0.373081901221124 1847 674163 SGTC_465 cgp-37157 41 µM 0.323002382002743 0.346481056993842 no 1179 0.373346719050947 1829 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2696 st077691 74.316 µM 0.322690219852935 0.346604913786956 no 1180 0.373464929837768 1760 757133 SGTC_1548 st061468 90.8 µM 0.322589754518275 0.346644778976493 no 1181 0.373502976978064 1839 390799 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.321740465368935 0.346981849336127 no 1182 0.373824659777638 1865 688798 SGTC_1955 wogonin 32.4 µM 0.31857169236236 0.348240555830943 no 1183 0.375025661026165 1847 5281703 A flavanone. SGTC_2591 skatole 100 µM 0.318501591200305 0.348268420527565 no 1184 0.375052243923231 1742 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_266 formosanin C 406 nM 0.318375269246691 0.34831863464321 no 1185 0.375100147673003 1776 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_324 1315-0088 19.6 µM 0.315863773727523 0.349317527646678 no 1186 0.376052954815196 1793 6787421 SGTC_631 k072-0230 41.5 µM 0.315098575056249 0.349622076802148 no 1187 0.376343405197374 1804 5773147 SGTC_2722 naftopidil 47.16 µM 0.312777072575832 0.350546626710299 no 1188 0.377225017736701 1841 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2537 larixol 68.93 µM 0.312036301085765 0.350841829374102 no 1189 0.377506467698008 1801 6708759 SGTC_2989 9073649 71.4286 µM 0.310040088539602 0.351637782097175 no 1190 0.378265235553418 1911 21367202 SGTC_3106 9121286 49.47 µM 0.308675014390755 0.352182455045492 no 1191 0.378784375958656 1852 15943471 SGTC_2358 9037157 4 µM 0.308393600845375 0.352294778526579 no 1192 0.378891425318337 1797 2388925 SGTC_1267 0828-0272 9.49 µM 0.307700070932253 0.352571649237337 no 1193 0.379155282873693 1872 745334 SGTC_552 k242-0005 476 µM 0.306524702010459 0.353041057837133 no 1194 0.379602587457895 1769 4088318 SGTC_2344 7990960 76.95 µM 0.306431990315058 0.353078093755397 no 1195 0.379637877174484 1763 140813 SGTC_397 arbidol 50 µM 0.306036667297358 0.353236030666611 no 1196 0.379788363907241 1867 131410 A RNA synthesis inhibitor. SGTC_3277 9138724 49.47 µM 0.304841040181701 0.353713853684907 no 1197 0.380243611338358 1810 15943418 SGTC_187 1488-2104 32.728 µM 0.304602573600555 0.353809182589426 no 1198 0.380334429833365 1843 2852859 SGTC_1573 oleylamine 1.06 µM 0.30424378565621 0.353952628181866 no 1199 0.380471084389775 1722 5356789 An amine of the fatty acid oleic acid. SGTC_936 3005-4620 401 µM 0.304020806351857 0.354041787105378 no 1200 0.380556019894433 1893 777207 SGTC_2841 9004761 38.96 µM 0.303638115680778 0.354194825736203 no 1201 0.380701804802951 1635 2991039 SGTC_753 1322-0200 289 µM 0.303536666876117 0.354235399230815 no 1202 0.380740454274337 1782 5403907 SGTC_2570 licareol 100 µM 0.302534303427729 0.354636373935781 no 1203 0.381122393734563 1742 443158 SGTC_2166 5933061 31.504 µM 0.301333544674201 0.355116924666701 no 1204 0.381580081993728 1872 2877375 SGTC_1929 genistein trimethyl ether 50.5 µM 0.300895215965047 0.355292403877081 no 1205 0.381747199238557 1950 136420 SGTC_381 3461-2219 42.7 µM 0.300832353607177 0.355317572523215 no 1206 0.381771167955004 1893 2883159 SGTC_3309 9129340 25.759 µM 0.299849219731464 0.35571127882688 no 1207 0.38214608486869 1817 17158987 SGTC_3195 9113082 49.47 µM 0.296928198021556 0.356881939610184 no 1208 0.383260663793722 1936 17018038 SGTC_374 0880-0231 82.3 µM 0.296926370282157 0.35688267253857 no 1209 0.383261361510837 1847 6833587 SGTC_467 ro 31-8220 72.8 µM 0.296519198862607 0.357045962529641 no 1210 0.383416803644268 1903 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3238 9133470 49.47 µM 0.296075417879975 0.357223964064379 no 1211 0.383586243252582 1890 3534688 SGTC_232 clozapine 119 µM 0.295825204836173 0.357324338772853 no 1212 0.383681786681883 1823 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1512 0259-0544 12.2 µM 0.295113281922188 0.357609985604367 no 1213 0.38395367191748 1828 18476 SGTC_3151 9099821 49.47 µM 0.295049134732914 0.357635727481686 no 1214 0.383978172705523 1737 17174189 SGTC_1295 1013-0063 9.78 µM 0.29429290812095 0.357939245417154 no 1215 0.384267045669986 1913 6826038 SGTC_1225 1216-0074 20.6 µM 0.293825178750573 0.358127017522406 no 1216 0.384445747016678 1766 4241466 SGTC_1690 st023502 41.2 µM 0.292479898750562 0.358667277545967 no 1217 0.38495986338698 1893 24207482 SGTC_1167 k781-0610 148 µM 0.292382246024791 0.358706505586541 no 1218 0.384997190541724 1785 4525169 SGTC_2598 perillyl alcohol 100 µM 0.291339556342348 0.359125456927651 no 1219 0.385395818648584 1849 10819 An apoptosis inducer. SGTC_2074 5212007 75.395 µM 0.287262770875035 0.360765126460094 no 1220 0.386955563190758 1934 758611 SGTC_429 1112-0049 25.5 µM 0.286268169034106 0.361165542043543 no 1221 0.387336367914944 1744 2836170 SGTC_1034 k072-0165 12.7 µM 0.286160031735823 0.361209086090279 no 1222 0.387377777149416 1932 5835461 SGTC_2041 5107442 45.335 µM 0.285878056251993 0.361322638660805 no 1223 0.387485760618069 1910 793005 SGTC_2065 5221596 34.26 µM 0.284790533340797 0.361760702517003 no 1224 0.387902312667383 1827 788581 SGTC_1152 3909-8331 15.9 µM 0.284405399752655 0.361915881216822 no 1225 0.388049860692401 1805 16001939 SGTC_3218 9131285 49.47 µM 0.2842171272371 0.361991748572635 no 1226 0.388121995412433 1930 17156417 SGTC_1399 3562-5772 25 µM 0.282198475683463 0.362805536047502 no 1227 0.388895663536222 1812 23847490 SGTC_2478 5763493 32.33 µM 0.282059216769221 0.362861698981308 no 1228 0.388949052177648 1857 1365576 YLR208W SEC13 SGTC_390 dec-rvkr-cmk 16.7 µM 0.279757106633528 0.363790563560215 no 1229 0.389831931035496 1850 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1769 st044406 64.4 µM 0.276790834700662 0.364988587310232 no 1230 0.390970359589523 1802 670903 SGTC_2082 5219693 150 µM 0.276190755387272 0.365231109331644 no 1231 0.391200778662756 1776 2834649 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.275712434945038 0.36542446112772 no 1232 0.39138447199704 1885 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3003 9075612 71.4286 µM 0.275677373564931 0.365438635359272 no 1233 0.391397937860756 1828 6501993 SGTC_2196 6573537 42.6665 µM 0.274355666070774 0.365973094704242 no 1234 0.391905654803145 1931 2903087 SGTC_1002 4049-0206 172 µM 0.274139178079186 0.366060660858851 no 1235 0.391988833454494 1780 4662749 SGTC_1703 st026983 48.3 µM 0.273837742194448 0.366182598785071 no 1236 0.392104658863719 1944 1104023 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.273423530509178 0.366350179225919 no 1237 0.392263833470864 1891 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2159 5658611 73.75 µM 0.273084795047 0.366487242684836 no 1238 0.392394017231908 1912 793844 SGTC_2073 5212005 126 µM 0.272768394248389 0.366615284191346 no 1239 0.3925156281509 1967 691789 SGTC_61 0978-8327 98.565 µM 0.272504179243088 0.366722218455331 no 1240 0.392617189127968 1962 6150059 YHR072W ERG7 SGTC_957 1187-1561 14.1 µM 0.271179618585085 0.367258456266539 no 1241 0.393126443935085 1891 1538454 SGTC_2154 5570129 200 µM 0.27050783976156 0.367530519621579 no 1242 0.39338479320822 1902 673366 SGTC_1790 st045711 43.5 µM 0.267623997834297 0.36869919919711 no 1243 0.394494378482473 1951 585119 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.26637536620844 0.369205585984984 no 1244 0.394975067497559 1931 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1579 chlormadinone acetate 49.4 µM 0.265922548037928 0.369389284076636 no 1245 0.395149429651459 1964 45114258 A steroidal progestin. SGTC_3100 9120536 49.47 µM 0.262908225712979 0.370612884695642 no 1246 0.396310658043343 1966 16421196 SGTC_2310 7668677 200 µM 0.262378878782441 0.370827897494222 no 1247 0.396514677359903 1869 2197143 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.261776872593576 0.371072472421598 no 1248 0.396746735228004 1937 140250 A respiratory chain inhibitor. SGTC_824 1304-0008 100 µM 0.260276264071609 0.371682345882979 no 1249 0.397325340168266 1854 768245 SGTC_2595 hexamethylquercetagetin 100 µM 0.259820020185698 0.371867835293618 no 1250 0.397501303643191 1855 386331 SGTC_3001 9076041 71.4286 µM 0.259716137399073 0.371910073787062 no 1251 0.397541371921268 1843 16004211 SGTC_3209 9113616 49.47 µM 0.257417346796536 0.372845150239795 no 1252 0.398428306585126 2014 16649353 SGTC_3118 9124250 49.47 µM 0.257279903983908 0.372901081503748 no 1253 0.398481352360708 1831 1504786 SGTC_2104 5389443 200 µM 0.256050106166387 0.373401657098179 no 1254 0.39895607371263 1932 2244536 SGTC_3199 9111318 49.47 µM 0.254802470129482 0.373909711938562 no 1255 0.399437833672354 1921 8548020 SGTC_145 3737-0113 38.366 µM 0.25380887783331 0.374314473415616 no 1256 0.399821607235024 1983 6849351 SGTC_656 4090-1979 187 µM 0.251289778893038 0.375341303377433 no 1257 0.400795038475242 1981 22330961 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.250398291418855 0.375704901806345 no 1258 0.401139675395464 1821 4174840 SGTC_785 1270-0111 65.3 µM 0.249074970196316 0.376244829679297 no 1259 0.401651395159451 1853 6741994 SGTC_1974 st069448 26.9 µM 0.248951354880961 0.376295278314366 no 1260 0.401699205031033 1978 6323587 YNR016C ACC1 SGTC_3289 9119912 71.43 µM 0.248928276789504 0.37630469694631 no 1261 0.401708130953648 1877 17014829 SGTC_110 0850-0284 111.64 µM 0.248707049669929 0.376394987907072 no 1262 0.401793697655833 1961 3906265 SGTC_286 k060-0067 22.9 µM 0.247971982021011 0.376695044722406 no 1263 0.40207804249455 1858 5985051 SGTC_675 1309-0189 238 µM 0.247265501770727 0.376983502296442 no 1264 0.402351377774692 1847 4246530 SGTC_1636 st007707 68.9 µM 0.245664562536349 0.37763742351745 no 1265 0.402970953306796 1960 403051 SGTC_1253 0550-0034 176 µM 0.243851670685694 0.378378342692011 no 1266 0.403672850276929 1875 5969915 SGTC_1849 st056239 19.2 µM 0.242713638134675 0.37884367924753 no 1267 0.404113620810964 1768 5393181 SGTC_42 0133-0086 60.653 µM 0.24141817965044 0.379373600368765 no 1268 0.404615512030571 1826 162923 Model of phenazepam hydroxylation. SGTC_166 k072-0058 166.424 µM 0.240826868182156 0.379615558055537 no 1269 0.404844652292825 2023 5846229 SGTC_193 1273-0060 1.558 µM 0.240496453592461 0.379750780352506 no 1270 0.404972706112703 1976 2847393 YHR072W ERG7 SGTC_653 0203-0016 55.2 µM 0.240213305386342 0.379866670565526 no 1271 0.405082449707302 1914 295302 SGTC_2902 5787006 60.46 µM 0.239898385638561 0.379995577280534 no 1272 0.405204516197249 1837 591003 SGTC_3270 9137563 49.47 µM 0.239396432304032 0.380201070377018 no 1273 0.405399098100893 1950 17015724 SGTC_1320 1313-0481 95.3 µM 0.238468726231528 0.380580950023192 no 1274 0.405758784304492 1998 6813365 YLR208W SEC13 SGTC_2114 5491910 81.25 µM 0.235957480255147 0.381609838881706 no 1275 0.406732832227336 1954 2849228 SGTC_225 nsc-122657 1.016 µM 0.235424824788056 0.381828182332795 no 1276 0.406939510037464 1948 275685 SGTC_694 1315-0438 43.2 µM 0.233029076896997 0.382810699197895 no 1277 0.407869413559904 1940 6793154 SGTC_1906 st060206 94.7 µM 0.232185213202432 0.383156955012436 no 1278 0.408197081061306 2001 5133468 SGTC_3264 9137442 49.47 µM 0.23214540783237 0.383173290338526 no 1279 0.408212538848941 2007 17015726 SGTC_662 k832-1615 104 µM 0.231741283845545 0.383339146479047 no 1280 0.408369482107799 1926 5878478 SGTC_1454 4239-0054 42.6 µM 0.230844547234873 0.383707251624453 no 1281 0.408717786021554 2006 1340767 SGTC_2858 9025781 8.96 µM 0.230355370287645 0.383908100178319 no 1282 0.408907818988273 2006 4894980 YPL153C RAD53 SGTC_387 norethindrone acetate 66.7 µM 0.230165505597443 0.383986064113318 no 1283 0.408981582426537 1857 541197 SGTC_3319 9138450 16.7555 µM 0.229065348404671 0.384437912820926 no 1284 0.409409062701964 1882 2029690 SGTC_252 miconazole 1.30953 nM 0.229065341185218 0.384437915786564 no 1285 0.40940906550753 1962 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1666 st014829 29 µM 0.227695782997165 0.385000630357339 no 1286 0.40994137550864 1881 3858230 SGTC_431 k089-0097 107 µM 0.227451798827865 0.385100902340469 no 1287 0.410036222966331 1956 5499420 SGTC_937 3122-0005 46.7 µM 0.227133601179258 0.385231685931118 no 1288 0.410159928399833 2016 759535 SGTC_1054 3429-0080 167 µM 0.22555425410839 0.385881012130542 no 1289 0.410774061927162 1979 1162877 SGTC_800 3448-7362 155 µM 0.22362158258647 0.386676037749986 no 1290 0.411525884221642 2027 15991913 SGTC_257 daunorubicin 18.5 µM 0.22150023643324 0.387549224471729 no 1291 0.412351476261841 2022 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1875 nocodazole 6 µM 0.220026099987534 0.388156342712006 no 1292 0.412925413947714 2042 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3090 9117696 49.47 µM 0.219142514337702 0.38852037571408 no 1293 0.413269516948244 2015 7923821 SGTC_545 4218-0007 221 µM 0.21818751519052 0.38891394085501 no 1294 0.413641506096967 1921 2840508 SGTC_2289 7946404 165.07 µM 0.21750638168481 0.389194712789664 no 1295 0.41390686708884 1899 1246120 YPR165W RHO1 SGTC_3345 9148410 3.559 µM 0.216798877660145 0.389486416259025 no 1296 0.414182543328572 2017 4903596 SGTC_591 4299-0174 154 µM 0.215628570203502 0.389969069934693 no 1297 0.414638641922963 1954 5509088 SGTC_576 1073-0113 22.7 µM 0.214983443657033 0.390235203133559 no 1298 0.414890113408512 2046 5439563 SGTC_816 0325-0417 81.3 µM 0.214876656721515 0.39027926077274 no 1299 0.414931742514906 1899 68101 SGTC_2772 vinpocetine 57.06 µM 0.214858906628833 0.390286584157028 no 1300 0.414938662185195 1991 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2075 5212009 200 µM 0.214481225180063 0.390442418278647 no 1301 0.415085903222684 2011 780898 SGTC_1645 Cervolide 78 µM 0.214171712362581 0.390570138650077 no 1302 0.415206577265568 1910 23173 A fragrance. SGTC_3060 1327-0027 12.5 µM 0.213629310079496 0.390793989261005 no 1303 0.415418070431713 2043 16000455 YPR107C YTH1 SGTC_116 0155-0182 31.788 µM 0.20938008212982 0.392548901853403 no 1304 0.417075770163113 1900 771486 SGTC_255 tunicamycin 200.472 nM 0.209054294438424 0.392683541464987 no 1305 0.417202927025658 2054 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1867 st057372 64 µM 0.208726765109455 0.392818913796789 no 1306 0.417330772389803 2022 688837 SGTC_2997 9067075 71.4286 µM 0.208359721112284 0.392970633484534 no 1307 0.417474052000902 1965 27209819 SGTC_1207 2099-0101 141 µM 0.208309439846121 0.392991418793789 no 1308 0.417493680693103 2048 5837381 SGTC_2315 7733312 200 µM 0.207026272369417 0.393521958658178 no 1309 0.417994670283516 1916 726316 SGTC_2476 5806916 10.51 µM 0.206656926006373 0.393674705715267 no 1310 0.418138899612443 1974 2870194 SGTC_501 nsc-95397 161 µM 0.206491422052639 0.393743156918985 no 1311 0.418203532288563 2023 262093 SGTC_2172 5754775 163.918 µM 0.206268787817189 0.393835241960984 no 1312 0.418290478991067 1878 2263357 SGTC_2993 9054257 71.4286 µM 0.206120118397396 0.393896737291193 no 1313 0.418348541987798 1978 6470217 YGL055W OLE1 SGTC_2049 5262831 67.185 µM 0.205789916995248 0.394033330620376 no 1314 0.418477508852117 1922 763417 SGTC_2139 5578692 56.4705 µM 0.205548268256764 0.394133300921898 no 1315 0.418571895229418 2073 650991 YMR113W FOL3 SGTC_3137 9097352 49.47 µM 0.203290012106519 0.395067879873762 no 1316 0.419454180862166 2019 44120435 SGTC_2339 9000433 200 µM 0.202845883635036 0.395251753615603 no 1317 0.419627746706554 1864 2988954 SGTC_577 r071-0003 38.6 µM 0.202561763354696 0.395369394561746 no 1318 0.41973878939571 1973 4568517 YMR134W ERG29 SGTC_2777 climbazole 1.536 µM 0.201739788897835 0.395709789479966 no 1319 0.420060077516095 2029 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2704 st078022 71.1 µM 0.201443069036484 0.395832686253697 no 1320 0.420176070577874 2057 54697681 SGTC_3328 9140624 29.0385 µM 0.199807918005676 0.39651012597569 no 1321 0.42081540426375 2046 4904392 SGTC_1627 st003713 25.6 µM 0.199767608676883 0.396526830003551 no 1322 0.420831167601015 1922 16195070 YER133W GLC7 SGTC_2322 7413319 38.22 µM 0.199464286582611 0.396652531579895 no 1323 0.420949788591702 1958 1840400 SGTC_2950 9072895 21.46 µM 0.199147853143507 0.396783678156867 no 1324 0.421073544720334 1891 17332245 SGTC_288 1315-0019 35.1 µM 0.198958261078271 0.396862260624946 no 1325 0.421147697321259 1961 6811474 SGTC_2549 cedrol 20.94 µM 0.19856311345904 0.397026055595356 no 1326 0.421302255095509 2057 6708665 A sedative which affects the nervous system. SGTC_2642 cholecalciferol 100 µM 0.19853068588958 0.397039498145392 no 1327 0.421314939332 2032 9821465 A vitamin D precursor, similar to steriods. SGTC_977 1348-1378 135 µM 0.196965406320009 0.397688515541097 no 1328 0.421927304601191 2017 X977 SGTC_1502 4534-4282 27.7 µM 0.196951196211694 0.397694408828734 no 1329 0.421932864715933 1946 3278949 SGTC_3007 9078383 71.4286 µM 0.196477123935728 0.397891031843438 no 1330 0.42211836808026 1926 6496995 SGTC_558 k064-0027 21.3 µM 0.196014762038287 0.398082822926166 no 1331 0.42229930584581 1997 5088526 SGTC_956 1185-0240 191 µM 0.194768856772582 0.398599755978885 no 1332 0.422786952020356 1969 1416193 SGTC_1160 4092-0570 10.5 µM 0.194513925862586 0.398705550198101 no 1333 0.422886746353127 1878 4994975 SGTC_1419 3993-2473 62.6 µM 0.193627531030448 0.399073454609467 no 1334 0.423233769747729 1988 704026 SGTC_1719 st032227 49.2 µM 0.192623900563695 0.399490126730836 no 1335 0.423626762758274 1904 3125804 SGTC_627 1391-0720 175 µM 0.19082313371157 0.400238028642552 no 1336 0.42433208181647 1983 997839 SGTC_901 1112-0062 60.1 µM 0.190641184550545 0.40031361692223 no 1337 0.424403360648704 1965 1908457 SGTC_1893 st059353 36.1 µM 0.189976101662075 0.400589948223622 no 1338 0.424663928797962 1924 3112488 SGTC_22 0964-0034 14.468 µM 0.188083749528956 0.401376462035516 no 1339 0.425405499877199 1973 138402 SGTC_569 4130-2812 160 µM 0.187984132630787 0.401417876673438 no 1340 0.425444544879866 2104 743552 SGTC_334 1502-1024 68.5 µM 0.186061087811521 0.402217578073168 no 1341 0.42619842822548 1992 3296216 SGTC_928 2764-0428 58.7 µM 0.184355472639266 0.402927203758094 no 1342 0.426867299365454 1992 662578 SGTC_1764 st044502 93.5 µM 0.183972712500714 0.403086496150366 no 1343 0.427017430895568 1968 8407 SGTC_605 1315-0399 119 µM 0.183435166073301 0.403310232741618 no 1344 0.427228292711757 2027 24020461 SGTC_1982 st072467 71.9 µM 0.182351379985001 0.403761420379178 no 1345 0.427653489576078 1945 3163533 SGTC_2475 5812728 15.03 µM 0.1814886751389 0.404120661961371 no 1346 0.42799201073965 2084 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1495 4469-0029 237 µM 0.181090615855617 0.404286446338358 no 1347 0.428148225142326 1992 793680 SGTC_1989 st071868 50.2 µM 0.180807956205546 0.404404179327135 no 1348 0.428259158946594 2090 16414057 SGTC_686 1319-0111 510 µM 0.180621466075426 0.40448186066728 no 1349 0.428332352758315 2070 4562600 SGTC_1405 3909-7894 12 µM 0.179226859841685 0.405062894660357 no 1350 0.428879787039906 2090 7104060 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.177899463766368 0.405616121401504 no 1351 0.429400965990695 1972 6708514 SGTC_2183 6420625 130.508 µM 0.176758277311887 0.406091891260094 no 1352 0.429849131408217 2052 2897619 SGTC_646 4092-0839 27.3 µM 0.176513943860506 0.406193773903895 no 1353 0.4299450975273 2059 877796 SGTC_3219 9131112 49.47 µM 0.176492398483211 0.406202758242624 no 1354 0.429953560039374 2095 17612988 YMR079W SEC14 SGTC_179 1273-0063 6.77 µM 0.176078052687507 0.406375548434415 no 1355 0.430116311474658 1971 3108139 SGTC_19 0279-0214 38.434 µM 0.175389048282772 0.406662916920427 no 1356 0.430386972706306 2055 3566274 YBR002C RER2 SGTC_2761 levamisole 97.89 µM 0.174925197732052 0.406856407040574 no 1357 0.43056920530039 2102 26879 An alkaline phosphatase inhibitor. SGTC_571 k831-0106 44.2 µM 0.174712099967535 0.406945306038499 no 1358 0.430652929807673 2125 4783639 SGTC_530 4358-1714 28 µM 0.172084643316217 0.408041807152487 no 1359 0.431685492760974 2042 1564641 SGTC_2592 piperlongumine 83.33 µM 0.171581100742735 0.408252030172497 no 1360 0.431883433255386 1962 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2539 epi(13)torulosol 80 µM 0.171035521884053 0.408479832647525 no 1361 0.432097917341075 1964 6708597 SGTC_493 zm226600 134 µM 0.170510876992805 0.408698923469843 no 1362 0.432304190509145 2051 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2318 6029776 164 µM 0.168602382968697 0.409496147569695 no 1363 0.43305470303053 2047 818325 SGTC_32 0928-0142 34.1 µM 0.167438702329326 0.409982429063517 no 1364 0.433512437468613 2104 2244242 SGTC_2063 5246145 200 µM 0.167413602359863 0.409992919423734 no 1365 0.433522311540675 2046 711240 SGTC_975 1335-0046 28.5 µM 0.166557388846953 0.410350806525091 no 1366 0.433859162014904 1935 16486740 SGTC_1749 st037932 54.2 µM 0.166290430456762 0.410462407252832 no 1367 0.433964198294383 2002 594497 SGTC_1317 1273-0028 910 nM 0.164777793689125 0.411094894776292 no 1368 0.434559441584927 2019 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1516 st013856 110 µM 0.164146739026753 0.411358829733358 no 1369 0.434807814180223 2037 5281404 A mutagen and neurotoxin. SGTC_950 1165-0508 94.1 µM 0.16352898608417 0.411617240187605 no 1370 0.435050976362371 1975 6148369 SGTC_951 1171-0579 82.7 µM 0.162752454069308 0.411942123435151 no 1371 0.435356672583211 2074 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_129 0088-0017 176.636 µM 0.161854534117366 0.412317867868885 no 1372 0.435710203572592 2127 182446 SGTC_2164 5685496 200 µM 0.161796630395658 0.412342101077696 no 1373 0.435733003317961 2103 759046 SGTC_3293 9120939 62.045 µM 0.161498021451385 0.412467076809529 no 1374 0.435850584778302 2058 934087 SGTC_3128 9127691 49.47 µM 0.161056121943398 0.412652039709848 no 1375 0.436024599309903 2048 41316314 SGTC_1424 4048-1941 275 µM 0.159298017331275 0.413388109426338 no 1376 0.436717041377244 2118 X1424 SGTC_1210 3013-0140 750 nM 0.158582142164625 0.413687913922349 no 1377 0.436999049612914 2155 905973 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.158349418980421 0.41378538793066 no 1378 0.437090734307643 2035 689007 SGTC_2768 sulfasalazine 50.2 µM 0.155575712257067 0.414947537333391 no 1379 0.438183735307042 2129 5384001 An antioxidant and salicylic acid derivative. SGTC_394 menadione 8.33 µM 0.153601840963607 0.415775019578859 no 1380 0.438961842644381 2130 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_337 1315-0038 354 µM 0.153531894827574 0.415804349128784 no 1381 0.438989420015123 2032 1626437 SGTC_3131 9127911 49.47 µM 0.15303129397397 0.41601427287067 no 1382 0.439186798458279 2058 45595681 SGTC_2245 6637752 200 µM 0.152010865706227 0.416442257039462 no 1383 0.439589182827044 2135 681890 SGTC_2740 felodipine 17.08 µM 0.151788953838585 0.416535343610437 no 1384 0.439676697369928 2141 3333 L-type calcium channel blocker SGTC_774 k060-0086 136 µM 0.150102922719628 0.417242744723195 no 1385 0.44034170705766 2157 5911235 SGTC_1927 st060202 13.8 µM 0.149178950824094 0.417630525608993 no 1386 0.440706214468269 2154 688887 SGTC_3047 9092122 49.47 µM 0.149008061706307 0.417702254690195 no 1387 0.440773635832269 2020 17173831 SGTC_525 k781-2675 26.7 µM 0.148075460877605 0.418093753200817 no 1388 0.4411416076588 2169 3651118 YDL195W SEC31 SGTC_1020 4335-0961 93.3 µM 0.14612861745594 0.418911283952325 no 1389 0.441909927717288 1952 669075 SGTC_2089 5281248 129.67 µM 0.145953869639961 0.418984682339913 no 1390 0.441978902524579 2043 2737878 SGTC_1026 k007-1105 30.6 µM 0.145117179942102 0.419336151655041 no 1391 0.442309177119461 2036 7066794 SGTC_2192 5915882 198.485 µM 0.144659749193102 0.419528332411652 no 1392 0.442489760141809 2135 2876149 SGTC_315 k915-0449 187 µM 0.143815903075359 0.419882908511994 no 1393 0.442822922294181 2071 20970215 YNL149C PGA2 SGTC_2785 7756463 72.73 µM 0.142833970784716 0.420295588972749 no 1394 0.443210653667944 2075 2201551 SGTC_1567 st069303 68.4 µM 0.140922529300382 0.421099168777281 no 1395 0.443965571973583 2043 5581319 SGTC_2433 5607874 27.82 µM 0.140732516794561 0.42117906903148 no 1396 0.444040628022986 2099 2252428 SGTC_919 tnp00227 403.569 nM 0.140612077703155 0.421229715347684 no 1397 0.444088203206866 2053 1269246 A methoxyflavone. YNL221C POP1 SGTC_696 1560-0013 611 µM 0.13796765795632 0.422342057749527 no 1398 0.445132989135344 2127 1650269 SGTC_121 0557-0495 61.343 µM 0.137890029903779 0.422374720433248 no 1399 0.445163665060413 2145 3104427 SGTC_841 0251-0215 91.2 µM 0.136692433038497 0.422878687323488 no 1400 0.445636955474165 2093 3888614 SGTC_1980 st071811 45.7 µM 0.135932911035454 0.423198371152817 no 1401 0.445937158849565 2133 4974850 SGTC_479 n-linoleoylglycine 10 µM 0.135904634120759 0.423210273921855 no 1402 0.445948335985385 2046 6433346 An anti-infammatory. SGTC_178 4092-0806 87.505 µM 0.135396753215637 0.423424071160856 no 1403 0.446149095527144 2170 2169044 SGTC_3278 9139605 49.47 µM 0.134960932616343 0.423607551915839 no 1404 0.446321381458539 2126 7958859 SGTC_2887 9044784 58.44 µM 0.132856262217295 0.424493851978795 no 1405 0.447153528937216 2194 6465546 SGTC_976 1348-1067 47.6 µM 0.132850453857041 0.424496298474264 no 1406 0.447155825778358 2134 5310671 YGL099W LSG1 SGTC_3153 9100258 49.47 µM 0.132222695287454 0.424760729038057 no 1407 0.447404075238453 2027 25236848 SGTC_2368 9071271 200 µM 0.128231599608472 0.426442684292442 no 1408 0.448982846810903 2060 27209959 SGTC_503 tyrphostin 8 294 µM 0.127612713422225 0.426703620263239 no 1409 0.449227734771113 2181 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_87 0100-0052 35.5 µM 0.127481367830148 0.426759002572208 no 1410 0.449279709587409 2154 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_311 1315-0136 58 µM 0.126251936811244 0.427277466149814 no 1411 0.449766250301647 2154 6759207 SGTC_2678 equilin 100 µM 0.126120944887456 0.427332714199265 no 1412 0.449818094115964 2193 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1788 fluconazole 20 µM 0.125568514246981 0.42756572679009 no 1413 0.45003674381343 2023 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2543 pimpinellin 60.67 µM 0.124619040591996 0.427966269208725 no 1414 0.450412576847677 2041 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_295 k015-0027 31 µM 0.12409935693938 0.428185533028506 no 1415 0.450618303656247 2119 3887424 SGTC_866 0495-0101 262 µM 0.122984737535442 0.428655885570622 no 1416 0.451059591946371 1972 635694 SGTC_551 k048-0028 34.9 µM 0.122924729325633 0.428681211009199 no 1417 0.4510833514812 2161 6836383 SGTC_2425 5628681 7.85 µM 0.12252180214026 0.428851267136962 no 1418 0.45124289022879 2133 5714958 SGTC_2254 7938975 95.19 µM 0.121717503126358 0.429190762420196 no 1419 0.451561375408797 2171 2969277 SGTC_1423 4048-0112 5.59 µM 0.12129645657516 0.429368507425629 no 1420 0.451728113270195 2200 X1423 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.120920619229394 0.429527179441221 no 1421 0.451876955112442 2180 165506 SGTC_2784 7567673 72.73 µM 0.120917027819789 0.42952869572709 no 1422 0.451878377441286 2195 3471247 SGTC_2028 5153890 36.43 µM 0.120196822175291 0.429832786072084 no 1423 0.452163617531662 2127 2830968 YPR165W RHO1 SGTC_758 0868-0029 16 µM 0.11974677023535 0.430022831347569 no 1424 0.452341874801101 2220 762687 SGTC_1701 st028638 40.4 µM 0.118246620684705 0.430656422494756 no 1425 0.452936125540288 2179 3490878 SGTC_2757 clomiphene 4.22 µM 0.118085182587907 0.430724616865609 no 1426 0.453000081942974 2215 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1680 diphenhydramine 100 µM 0.11802048149024 0.430751948359025 no 1427 0.453025714707511 2045 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2624 nerol 100 µM 0.117501941128625 0.430971005801551 no 1428 0.453231152951311 2153 637566 A natural product oil. SGTC_1450 4112-4260 37.6 µM 0.117234698521513 0.431083910772931 no 1429 0.453337035525492 2195 1633175 SGTC_2623 humulene 100 µM 0.116256163926005 0.431497371219693 no 1430 0.453724763044164 2107 6187145 An anti-inflammatory. SGTC_1279 0874-0590 65.2 µM 0.116146242439824 0.431543821068521 no 1431 0.453768320306825 2130 3523074 SGTC_1030 k029-0042 36.7 µM 0.115148790612147 0.431965360439793 no 1432 0.454163593876407 2066 6080581 SGTC_1912 st060209 90.8 µM 0.114075414714027 0.432419073091202 no 1433 0.454589005598608 2076 688787 SGTC_3234 9132280 49.47 µM 0.113466193036073 0.432676628887338 no 1434 0.454830482001641 2111 17612295 SGTC_3344 9148862 3.898 µM 0.112565566150017 0.433057432113646 no 1435 0.455187492861048 2177 4905352 SGTC_2729 fluphenazine 10.66 µM 0.112334326214703 0.43315521507008 no 1436 0.455279162828954 2201 3372 An atypical antipsychotic. SGTC_1047 2043-3044 82 µM 0.111775460167216 0.433391556077114 no 1437 0.455500722759573 2140 669592 SGTC_2582 agaric acid 100 µM 0.110481651463835 0.433938791075073 no 1438 0.456013700396009 2157 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_190 3970-0790 3.722 µM 0.110069539288179 0.434113126489905 no 1439 0.456177112734353 2208 2832352 SGTC_3335 9143315 29.6265 µM 0.109148261703022 0.434502899953986 no 1440 0.456542448107611 2090 4899691 SGTC_1922 5578187 25 µM 0.108191656691123 0.434907687099891 no 1441 0.456921831551759 2207 1350412 SGTC_1727 st034309 9.9045 µM 0.107283406866299 0.435292075917036 no 1442 0.457282073982372 2227 870305 SGTC_1407 3909-7909 12.3 µM 0.106899984392553 0.435454366070301 no 1443 0.457434162786962 2157 4411780 SGTC_361 000s-0510 1.45 µM 0.106062366342817 0.435808940089672 no 1444 0.457766434991513 2128 660 SGTC_1176 0848-0131 83.3 µM 0.105001468745764 0.436258105123198 no 1445 0.45818732163669 2234 6769040 SGTC_1936 st074407 74.3 µM 0.104479264150626 0.436479227421362 no 1446 0.458394511510823 2182 809813 SGTC_2749 bexarotene 57.39 µM 0.104433736957642 0.436498506396389 no 1447 0.458412575414623 2098 82146 An retinoic acid receptor inhibitor. SGTC_1133 3473-0247 50 µM 0.102356277652897 0.437378388451137 no 1448 0.45923694335769 1990 711311 SGTC_3101 9120531 49.47 µM 0.102263473512984 0.437417701751407 no 1449 0.459273773590846 2228 24824904 SGTC_601 0986-0029 62.9 µM 0.101966748577869 0.437543403267234 no 1450 0.459391534135547 2153 24747981 SGTC_2255 7941087 197.44 µM 0.101919792589577 0.43756329579977 no 1451 0.459410169777762 2238 935561 SGTC_2019 4016004 108 µM 0.10170233591966 0.437655421652642 no 1452 0.459496473983458 2131 45595336 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.101467255596646 0.437755017594828 no 1453 0.459589774811696 2203 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1348 1493-0373 93.8 µM 0.101159427024617 0.437885440583084 no 1454 0.4597119519946 2174 3010129 SGTC_200 k038-0079 37.545 µM 0.0990739301769695 0.43876921566404 no 1455 0.460539785467774 2185 3436683 SGTC_1430 4049-0248 69.1 µM 0.0954991165545021 0.440284829421261 no 1456 0.46195919597088 2234 22774488 SGTC_902 1120-0002 2.07 µM 0.0952161477109325 0.440404837401772 no 1457 0.462071572120469 2222 3280475 SGTC_2473 5854593 8.94 µM 0.094928294997995 0.440526922263607 no 1458 0.462185890920347 2111 2872951 SGTC_2618 avocadyne 43.43 µM 0.0947310439613194 0.440610584165516 no 1459 0.462264229668421 2161 3015189 SGTC_68 0986-0284 82.829 µM 0.0941239161403262 0.440868107510911 no 1460 0.46250536119166 1953 423278 YIL048W NEO1 SGTC_3339 9145883 14.936 µM 0.0933205580415853 0.441208903607685 no 1461 0.462824450196826 2233 2030670 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0932356074861869 0.441244943408693 no 1462 0.462858193448678 2176 6708739 YPR165W RHO1 SGTC_2659 sanguinarine 24.21 µM 0.091682946388702 0.441903736664416 no 1463 0.46347497356394 2221 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2300 7976697 71.57 µM 0.0899509429050949 0.442638814372685 no 1464 0.464163099305106 2158 2236109 SGTC_2235 salicylic acid 500 µM 0.0868410260889591 0.44395918484288 no 1465 0.465398938340801 2257 338 A COX inhibitor and kinase inhibitor. SGTC_1836 st055642 81 µM 0.0860951708092178 0.444275944033403 no 1466 0.465695381253955 2184 8571 SGTC_1820 st053765 18.6 µM 0.0845148998591316 0.444947190716394 no 1467 0.466323528424923 2160 3690829 SGTC_195 4234-0266 16.654 µM 0.0844927145141717 0.444956615443417 no 1468 0.466332347552527 2131 2303354 SGTC_2760 etidronate 98.04 µM 0.0843872651684564 0.445001412616328 no 1469 0.466374266046477 2222 3305 A chelator and antioxidant. SGTC_317 4495-0002 170 µM 0.0840104482008324 0.445161498385948 no 1470 0.466524062337272 2117 15991618 SGTC_1370 2001-0092 44.6 µM 0.083632264486459 0.44532217379209 no 1471 0.466674406719694 2227 790957 SGTC_1082 camptothecin 424.86 nM 0.0823641899867819 0.445860994244065 no 1472 0.467178555757532 2269 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1759 st043059 70 µM 0.0815409940944175 0.44621083389775 no 1473 0.467505862414306 2197 669426 SGTC_2090 5301565 104.445 µM 0.080925615311477 0.446472383342972 no 1474 0.467750554349423 2206 2056344 SGTC_1479 0549-0158 134 µM 0.079637704034194 0.447019849052648 no 1475 0.468262703476208 2248 5440202 SGTC_3180 9109287 49.47 µM 0.0792929284500464 0.447166423537475 no 1476 0.468399815436196 2206 18891271 SGTC_3259 9138485 49.47 µM 0.0790087927912168 0.447287223588893 no 1477 0.46851281464649 2262 17646153 SGTC_1522 st012842 45.6 µM 0.0784546510163101 0.447522830586494 no 1478 0.468733201114384 2247 3491067 YOR116C RPO31 SGTC_2873 9040596 71.43 µM 0.0783092497307988 0.44758465458762 no 1479 0.468791029919336 2124 6463863 SGTC_2860 9025725 38.96 µM 0.0709044859901977 0.450734779374983 no 1480 0.471736886530179 2145 40546248 SGTC_1780 st038448 24.544 µM 0.0703798679143664 0.450958081847814 no 1481 0.471945657292718 2237 728868 YDL195W SEC31 SGTC_1227 3909-8010 46.6 µM 0.0703741418131136 0.450960519235357 no 1482 0.47194793602642 2203 15982272 SGTC_2743 auranofin 4.32 µM 0.0703246343722104 0.450981592781892 no 1483 0.47196763782496 2248 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3340 9146634 11.102 µM 0.0696038513597446 0.451288419944615 no 1484 0.472254485718047 2198 4907387 SGTC_2853 9015042 58.44 µM 0.069195802103087 0.45146213367253 no 1485 0.472416882268449 2264 6457456 SGTC_590 k048-0076 22.4 µM 0.0691295433813709 0.451490342050979 no 1486 0.472443252527755 2289 6832814 SGTC_3352 9151559 45.5865 µM 0.0681442946395816 0.451909821607684 no 1487 0.472835385129458 2221 17159339 SGTC_99 0109-0120 622.8 µM 0.0681409380652703 0.451911250794982 no 1488 0.472836721103523 2274 759414 SGTC_2975 9084847 53.72 µM 0.06812777308021 0.451916856286736 no 1489 0.472841960996007 2130 27211724 SGTC_2968 9090663 33.37 µM 0.0671378044834526 0.452338400351374 no 1490 0.473235999074782 2157 25236811 SGTC_151 3013-0144 2.285 µM 0.0670159753980488 0.452390280798245 no 1491 0.473284492631347 2287 906558 YHR107C CDC12 SGTC_3089 9117425 49.47 µM 0.0650966447447307 0.453207727078291 no 1492 0.474048525937074 2135 9401657 SGTC_2884 9058502 51.95 µM 0.0643512975573025 0.453525225399776 no 1493 0.474345254259462 2231 6471554 SGTC_3216 9129716 49.47 µM 0.0639137070049509 0.453711641332844 no 1494 0.474519468991603 2253 8056934 SGTC_1884 5633444 25 µM 0.0638981189913822 0.453718282098982 no 1495 0.474525675023724 2241 5724239 SGTC_2755 lomerizine 42.69 µM 0.0636278604241546 0.453833419026076 no 1496 0.474633273637172 2256 3949 A calcium channel blocker. SGTC_2507 purpurin 79.67 µM 0.0627030515526853 0.454227440095059 no 1497 0.475001483694991 2291 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2461 5755302 26.15 µM 0.0605927971221132 0.455126696322268 no 1498 0.475841755024562 2290 2788904 SGTC_1552 6-methylflavone 10.6 µM 0.0602092561953544 0.455290161906118 no 1499 0.475994486856763 2308 689013 SGTC_719 2810-4230 27.3 µM 0.0597336160141908 0.455492890810185 no 1500 0.476183898909905 2311 721079 SGTC_982 1491-0518 27.5 µM 0.059346860135361 0.455657743703981 no 1501 0.476337918935539 2233 3091256 SGTC_3318 9139014 38.6185 µM 0.0584227299234754 0.456051680770984 no 1502 0.47670595491566 2295 16643984 SGTC_1300 1094-0077 113 µM 0.0584019284334877 0.456060548502693 no 1503 0.476714239364179 2261 5532636 SGTC_71 0417-1750 47.813 µM 0.0581658537489321 0.456161189314882 no 1504 0.47680825970715 2308 6811472 SGTC_1497 4476-2978 41.3 µM 0.0574761677206963 0.456455224908257 no 1505 0.477082945061029 2260 1528379 SGTC_818 4072-2707 53.5 µM 0.0565839361024674 0.456835647632161 no 1506 0.477438315587211 2303 882871 SGTC_704 1310-0270 142 µM 0.0563787977921541 0.456923118503265 no 1507 0.47752002349835 2253 5718033 SGTC_2925 9010536 32.5 µM 0.0551058225723639 0.45746596098689 no 1508 0.478027078726686 2249 2994177 SGTC_321 4534-3890 65.3 µM 0.0546112779375836 0.457676874092652 no 1509 0.478224076836887 2312 699746 SGTC_1886 st057356 49.9 µM 0.0520095093618804 0.45878666975478 no 1510 0.479260558147741 2279 24207747 SGTC_2020 4017018 200 µM 0.0519229650826528 0.458823591161553 no 1511 0.479295037732512 2269 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2792 7535235 81.82 µM 0.0515657323721155 0.45897599706717 no 1512 0.479437362300913 2254 1281891 SGTC_2008 4012253 172 µM 0.0498027075287702 0.459728242831932 no 1513 0.480139804533306 2295 603940 SGTC_620 0109-0052 432 µM 0.0496756899564581 0.459782444169355 no 1514 0.480190414570176 2318 493037 SGTC_1635 st007035 42.4 µM 0.0495333863072875 0.459843169317236 no 1515 0.480247115709805 2318 3716403 SGTC_1876 myriocin 605 nM 0.0495110830199027 0.459852686870168 no 1516 0.480256002530202 2325 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1297 1068-0111 14.1 µM 0.0489827060705258 0.460078169566635 no 1517 0.480466538975542 2278 767057 SGTC_1050 3232-1156 69.3 µM 0.0468575069028028 0.460985218540946 no 1518 0.481313397723848 2256 700529 SGTC_3043 9092303 49.47 µM 0.0468291483586758 0.460997323537057 no 1519 0.481324698740411 2292 25236084 SGTC_181 1447-1644 8.07 µM 0.0453823240532411 0.46161495593335 no 1520 0.481901284916292 2324 534600 SGTC_3117 9124945 49.47 µM 0.0441073054807133 0.462159323266768 no 1521 0.482409434761083 2297 17592065 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0438200020265569 0.462281996883457 no 1522 0.482523941542853 2322 66535 A nucleotide analog. SGTC_794 k038-0031 316 µM 0.0430997599352045 0.462589543572439 no 1523 0.482811005333487 2318 6624242 SGTC_1732 st034308 51.822 µM 0.0430688942103887 0.462602723880115 no 1524 0.482823307552776 2315 830119 SGTC_1889 st059080 5.18 µM 0.0429177752464979 0.462667255419086 no 1525 0.482883539603784 2327 176925 Isolated from Daphnopsis sellowiana. SGTC_289 k017-0060 526 µM 0.0426812868665617 0.462768243783594 no 1526 0.48297779844593 2320 5512909 SGTC_2390 9097792 176.6 µM 0.0399539040192176 0.463933098308937 no 1527 0.484064938093968 2288 4497149 SGTC_1330 1469-0054 61.8 µM 0.0395142639808933 0.464120896049505 no 1528 0.484240190693207 2343 7102664 SGTC_1391 3442-0225 151 µM 0.03869220604658 0.464472069793282 no 1529 0.484567893715846 2327 5227075 SGTC_2647 atorvastatin 60.16 µM 0.0370978831654443 0.465153224936085 no 1530 0.485203479928763 2309 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2267 7931562 200 µM 0.0365436011450467 0.465390059240984 no 1531 0.485424456611902 2326 934880 SGTC_1684 st024538 14.6195 µM 0.0350944339738027 0.466009318891048 no 1532 0.486002219862742 2327 6732859 SGTC_1840 st055363 71 µM 0.0347670869209991 0.466149212629777 no 1533 0.486132732794394 2230 676033 SGTC_2929 9013348 24.6 µM 0.0332387243784396 0.466802422660851 no 1534 0.486742108791751 2334 2995952 SGTC_1356 1502-0781 85.8 µM 0.0321416672850205 0.467271351396997 no 1535 0.48717953743713 2344 567702 SGTC_2653 dihydrofissinolide 100 µM 0.0304422733931562 0.467997833883237 no 1536 0.487857165586448 2316 6857746 SGTC_2536 dehydroabietamide 32.04 µM 0.0303400160848597 0.468041551801072 no 1537 0.487897941515075 2353 3983547 SGTC_1623 st003709 20.3 µM 0.0301809473522484 0.468109558990195 no 1538 0.487961371709876 2345 16192618 SGTC_1364 1653-0028 37.6 µM 0.0301194772967397 0.468135839738763 no 1539 0.487985883570387 2312 5718652 SGTC_609 0986-0026 86.3 µM 0.0281647651931822 0.468971624107149 no 1540 0.48876536968573 2348 2848610 SGTC_1907 st060210 83.7 µM 0.0266769963032486 0.46960784748 no 1541 0.489358680446182 2349 688793 SGTC_344 k064-0035 6.43 µM 0.0263676682481266 0.46974013705682 no 1542 0.48948204108972 2331 5088750 SGTC_2516 gossypol 71.55 µM 0.0246193499961334 0.470487898437802 no 1543 0.490179292455989 2351 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1720 st037298 9.481 µM 0.0239240917025652 0.470785291733011 no 1544 0.490456578690541 2343 597396 SGTC_2906 7926292 26.41 µM 0.0238875027224787 0.470800942940967 no 1545 0.490471171411321 2326 2966319 SGTC_1312 1218-2183 165 µM 0.0231564692771956 0.471113657346833 no 1546 0.490762730885813 2372 6744073 SGTC_1841 st054148 70 µM 0.0231033576752952 0.471136377609784 no 1547 0.490783913682308 2294 675442 SGTC_3142 9086498 49.47 µM 0.0223609266074743 0.471453987116505 no 1548 0.491080024301238 2365 25236367 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0220575863627081 0.471583760286043 no 1549 0.491201009707988 2345 115019 SGTC_85 0868-0259 160.055 µM 0.0216513996215264 0.471757537337668 no 1550 0.491363016078401 2318 83173 SGTC_2190 6049624 200 µM 0.0206138387227366 0.472201456695117 no 1551 0.491776850553873 2353 2265554 SGTC_756 0508-1999 28.3 µM 0.0201488541959924 0.472400411083049 no 1552 0.491962314014958 2351 6753853 SGTC_2802 7925815 54.55 µM 0.0200184952390476 0.472456189416903 no 1553 0.49201430922718 2350 1262923 SGTC_992 3909-8734 162 µM 0.0199503417073883 0.472485351344633 no 1554 0.492041493123659 2361 4288319 SGTC_3250 9135583 49.47 µM 0.0175770507119527 0.473500939732818 no 1555 0.492988132364021 2380 7699353 SGTC_1136 pergolide 1.05886 µM 0.01647961068641 0.473970619401701 no 1556 0.493425884097718 2358 47811 A dopamine receptor agonist. SGTC_3031 9088762 49.47 µM 0.0163142443779669 0.474041395618473 no 1557 0.493491846841892 2374 205253 SGTC_1170 0310-0127 64.8 µM 0.0159673822383213 0.474189854091908 no 1558 0.493630206789828 2368 774975 SGTC_2034 5197015 53.07 µM 0.0158543763766232 0.474238221857224 no 1559 0.493675283899835 2363 780676 SGTC_1244 0416-0015 52.5 µM 0.0152481554183721 0.474497697632791 no 1560 0.493917101825027 2368 96201 SGTC_1005 4092-0690 4.4 µM 0.0150218846946246 0.474594549209838 no 1561 0.494007360445044 2367 1529343 SGTC_1072 oxiconazole 14.9 nM 0.0149906312228451 0.474607926878464 no 1562 0.494019827372567 2378 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1880 MG-132 525 µM 0.013296355481241 0.475333183456351 no 1563 0.49469567791831 2381 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1464 k208-0027 110 µM 0.0117306805517653 0.476003463521112 no 1564 0.495320242879609 2364 X1464 SGTC_864 0469-0573 172 µM 0.0115079246407873 0.476098832969942 no 1565 0.495409103631857 2386 689425 SGTC_425 3825-7017 13.1 µM 0.0114085185036705 0.476141392590291 no 1566 0.495448758339632 2358 3397440 SGTC_3173 9105693 49.47 µM 0.00855634285145514 0.47736263357483 no 1567 0.496586554721287 2386 17096658 SGTC_2419 paclitaxel 166.5 µM 0.0084347243349839 0.477414712846064 no 1568 0.49663507173869 2382 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_396 dithiazanine 1.25 µM 0.00820975969810888 0.477511047830583 no 1569 0.496724816535842 2381 10578 An antihelmenthic. SGTC_2182 6325192 200 µM 0.00770471421017821 0.477727324596952 no 1570 0.49692629415372 2395 736248 SGTC_2849 9019321 12.99 µM 0.00603901365837667 0.478440677443987 no 1571 0.497590796763575 2382 16489627 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.00578791087223069 0.4785482207597 no 1572 0.497690970529927 2341 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1699 st031318 29.054 µM 0.00566822922456415 0.478599479049389 no 1573 0.497738715816054 2382 5340658 SGTC_2345 9052315 157.45 µM 0.00453720710960902 0.479083900329841 no 1574 0.498189922459492 2391 6469265 SGTC_2572 astragaloside iv 100 µM 0.00439861858982862 0.47914326048468 no 1575 0.498245210727725 2386 45006101 An anti-inflammatory agent. SGTC_1013 4112-3890 241 µM 0.00331725234231896 0.479606446436684 no 1576 0.498676610213022 2401 705171 SGTC_2108 5365811 200 µM 0.00277751002005525 0.47983764677802 no 1577 0.498891935243467 2394 780283 SGTC_119 0121-0043 24.815 µM 0.00212864500820288 0.480115599143033 no 1578 0.499150794147573 2397 1092378 SGTC_1268 0828-0275 2.46 µM 0.00190748708475023 0.480210338117553 no 1579 0.499239023214043 2397 745337 SGTC_692 k241-0027 77.8 µM 0.000560450004036851 0.480787401806419 no 1580 0.499776412809044 2403 3600480 SGTC_167 3672-0051 66.205 µM 0 0.481027507607518 no 1581 0.5 2405 3237971 SGTC_667 1498-1044 59 µM 0 0.481027507607518 no 1582 0.5 2405 6739982 SGTC_1383 3049-0032 20.7 µM 0 0.481027507607518 no 1583 0.5 2400 712864 SGTC_655 k060-0012 42 µM -0.000436893605449738 0.48121468463762 no 1584 0.499825704674294 2407 5994525 SGTC_2960 9079389 5.97 µM -0.000613117095813141 0.481290184718796 no 1585 0.499755401682968 2407 16457355 SGTC_1940 st075990 51.1 µM -0.000769748666487795 0.481357291524834 no 1586 0.499692914741981 2415 1084979 SGTC_1221 2958-7315 257 µM -0.000789671308873545 0.481365827165704 no 1587 0.499684966760012 2413 4562705 SGTC_2397 5161689 200 µM -0.00171931107630622 0.481764130713032 no 1588 0.499314094456425 2408 2259942 SGTC_2982 9019404 25.97 µM -0.00195620714322069 0.48186563160339 no 1589 0.499219586759087 2414 22333232 SGTC_2060 5238662 140 µM -0.00302060547567889 0.482321699929009 no 1590 0.498794954595824 2413 790130 SGTC_1408 3909-7976 48.8 µM -0.00305137528679603 0.48233488437799 no 1591 0.498782679273782 2418 24152374 SGTC_136 0097-0015 404.482 µM -0.00307084580448888 0.482343227242147 no 1592 0.498774911697446 2407 4861337 SGTC_2836 9010338 19.48 µM -0.0035760904165469 0.482559720694623 no 1593 0.49857334937507 2413 2994051 SGTC_1900 st060200 72.8 µM -0.00406813452390558 0.48277056277518 no 1594 0.498377053612606 2410 688945 SGTC_2227 7312221 64.1025 µM -0.00411721379953286 0.482791593627795 no 1595 0.498357473978448 2415 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1768 st044301 37.178 µM -0.00419205541471636 0.482823663936117 no 1596 0.498327616751509 2416 3931349 SGTC_3056 9094900 49.47 µM -0.00445732176566419 0.482937333857872 no 1597 0.498221791778481 2418 25236784 SGTC_3200 9114385 49.47 µM -0.00667275383067571 0.483886727256386 no 1598 0.497337976124969 2427 17018030 YLR208W SEC13 SGTC_2056 5235370 200 µM -0.0072112141368045 0.484117491132346 no 1599 0.497123166721148 2422 5511916 SGTC_748 act1.228 77.9 µM -0.00739466356853531 0.48419611189181 no 1600 0.497049982938196 2426 4421505 YNR035C ARC35 SGTC_1648 st011736 69.8 µM -0.00750688593906049 0.484244207236229 no 1601 0.497005213932482 2420 2855514 SGTC_2681 menadione 3.18 µM -0.00753441131727547 0.484256003872416 no 1602 0.496994233205869 2426 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_123 0083-0120 66.675 µM -0.00755755788576753 0.484265923879291 no 1603 0.496984999323952 2420 16001701 SGTC_925 2064-1272 59.6 µM -0.00785628154743499 0.484393949809122 no 1604 0.496865829364798 2430 6815817 SGTC_2676 harmalol 100 µM -0.00790298212313515 0.484413964722352 no 1605 0.496847199109006 2414 5459187 A monoamine oxidase inhibitor SGTC_3129 9127257 49.47 µM -0.00806902278569206 0.484485126677843 no 1606 0.496780960580778 2434 837894 SGTC_2705 st078069 42.8 µM -0.0083997419351871 0.484626868255683 no 1607 0.496649027202658 2427 1530061 SGTC_3015 9080845 49.47 µM -0.00954379188518347 0.485117206849539 no 1608 0.496192635700041 2435 5296973 SGTC_1761 st044296 37 µM -0.0101970033339593 0.485397182723543 no 1609 0.495932054733542 2422 1826700 SGTC_274 sirtinol 40.1 µM -0.0111160746431232 0.485791122136899 no 1610 0.495565419161008 2441 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1791 st048313 56.1 µM -0.0119120773432648 0.486132322156349 no 1611 0.495247881086326 2430 1204976 SGTC_1646 st011709 75.6 µM -0.0122061677059201 0.486258384156387 no 1612 0.495130564537367 2423 5757843 SGTC_1031 k035-0009 16 µM -0.0131801055838157 0.486675872912515 no 1613 0.494742050853835 2423 5180959 SGTC_454 lyso-paf C-16 6.67 µM -0.0132684541443665 0.486713745185239 no 1614 0.494706807959431 2442 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1984 st072354 53.1 µM -0.013828052849012 0.486953630467665 no 1615 0.494483580867187 2441 5762938 SGTC_21 0849-0113 22.993 µM -0.0143555613546976 0.487179763847556 no 1616 0.494273156317425 2424 1560156 SGTC_849 0386-0493 241 µM -0.0145083463809944 0.48724526080507 no 1617 0.494212210257975 2437 726119 SGTC_2023 5144124 124 µM -0.0163965403106364 0.48805473287868 no 1618 0.493459019905732 2441 2830192 SGTC_2951 9072950 58.06 µM -0.0168615367352173 0.488254085347711 no 1619 0.493273538820246 2430 16488155 SGTC_2406 ethylparaben 405.7 µM -0.0169832074379913 0.488306248289005 no 1620 0.493225006182216 2445 8434 A possible steroid mimic. SGTC_2091 4-phenylthiadiazole 200 µM -0.0172192947467476 0.488407464748517 no 1621 0.493130834744462 2446 270010 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0182680731544947 0.488857110887014 no 1622 0.492712498573322 2443 390807 SGTC_1476 4112-3294 3.34 µM -0.0186306202977703 0.489012550212516 no 1623 0.492567887803308 2476 704369 SGTC_3320 9137005 35.139 µM -0.0190072098795154 0.489174011893286 no 1624 0.492417676898747 2450 4908713 SGTC_1241 0364-0022 50.8 µM -0.0190855663920619 0.489207607242526 no 1625 0.492386422842407 2461 4563895 SGTC_833 3852-0053 558 µM -0.0197524871402047 0.489493552541632 no 1626 0.492120410124465 2458 3123681 SGTC_1583 clindamycin 39.6 µM -0.0198315418742188 0.489527447978674 no 1627 0.492088878025152 2447 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1837 st055472 66.5 µM -0.020563202161314 0.489841157546228 no 1628 0.491797047338124 2529 676091 SGTC_4 0960-0234 25.671 µM -0.020988822524711 0.490023651125596 no 1629 0.491627286023115 2410 6821112 SGTC_3054 9094397 49.47 µM -0.0233646983131358 0.491042394560475 no 1630 0.490679681989559 2457 2598354 SGTC_1616 st002734 56.1 µM -0.0236762571057022 0.491175991237447 no 1631 0.490555422390635 2465 4026101 SGTC_515 4092-1064 102 µM -0.0241171156886071 0.491365033463002 no 1632 0.49037959547395 2455 717353 SGTC_204 PMA1.184 62.41 µM -0.0244484527100304 0.491507113608889 no 1633 0.490247450093391 2437 2252213 YGL008C PMA1 SGTC_3210 9128157 49.47 µM -0.0246334063897391 0.491586423796857 no 1634 0.490173686466427 2513 17590849 SGTC_2349 9023730 187.07 µM -0.0247795544717144 0.491649093949793 no 1635 0.49011539960954 2463 4126287 SGTC_1985 st071382 65.5 µM -0.0254774362188626 0.491948357318324 no 1636 0.489837072966867 2452 6123237 SGTC_1414 3917-0015 5.4 µM -0.0255018996830356 0.491958847744228 no 1637 0.489827316626659 2456 6618702 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0258030970708527 0.492088007700976 no 1638 0.48970719578367 2476 5393153 SGTC_2808 7946468 45.46 µM -0.0272012885818172 0.492687593120963 no 1639 0.489149593973979 2475 2970879 SGTC_1264 0783-0040 158 µM -0.0272751484910753 0.492719266881935 no 1640 0.489120139061985 2447 2855798 SGTC_1327 1436-0082 2.18 µM -0.0275629116120523 0.492842670398178 no 1641 0.489005381332406 2497 15992205 SGTC_419 nsc-638432 893 µM -0.0284473416844376 0.493221951105276 no 1642 0.488652683129415 2482 368090 SGTC_2208 7283366 200 µM -0.0289638486554182 0.4934434538124 no 1643 0.488446711541788 2455 898663 SGTC_2304 7443016 91.4 µM -0.0291340187344149 0.493516431266127 no 1644 0.488378852139797 2450 939854 SGTC_2916 7875993 68.79 µM -0.0292049025813154 0.493546829874423 no 1645 0.488350585604231 2464 1299250 SGTC_2450 5739737 12.93 µM -0.0295262410563062 0.493684636666666 no 1646 0.488222445362725 2482 2262825 SGTC_1708 st033234 31.827 µM -0.0295645266975266 0.49370105560827 no 1647 0.488207178266716 2519 674664 SGTC_3208 9114115 49.47 µM -0.0295969806514322 0.493714973617136 no 1648 0.488194236675658 2492 650895 SGTC_2646 retinol 96.75 µM -0.0297181068612025 0.493766919147556 no 1649 0.488145935556123 2483 445354 A vitamin A analog and teratogen. SGTC_1077 5-fluorocytosine 377 nM -0.0298281857192599 0.49381412706224 no 1650 0.488102039905235 2486 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2124 5246320 200 µM -0.0318066981163844 0.494662636957422 no 1651 0.487313102508037 2507 579342 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0325339266228196 0.49497452431033 no 1652 0.487023130404792 2526 5282362 SGTC_612 0302-0167 22.4 µM -0.0329540893776607 0.495154721422141 no 1653 0.486855599553326 2485 235821 SGTC_230 MPP+ 141.667 µM -0.0331945645125529 0.495257855534264 no 1654 0.486759716313079 2486 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_689 0833-0039 98 µM -0.0334813517395226 0.495380852223915 no 1655 0.486645368325102 2489 5374726 SGTC_961 1252-1571 372 µM -0.034658384636788 0.4958856600363 no 1656 0.486176072611976 2476 6813498 SGTC_3327 9140648 26.9345 µM -0.0349345889719264 0.496004119991864 no 1657 0.486065949713348 2472 8029710 SGTC_2400 5203494 178.7 µM -0.0361440143928227 0.496522828683787 no 1658 0.485583763414267 2475 6777674 SGTC_2969 9091408 28.7 µM -0.0363257825467173 0.496600787489889 no 1659 0.485511296001858 2515 4286311 SGTC_2834 9001755 58.44 µM -0.0365626088194279 0.496702360446401 no 1660 0.485416878711159 2582 2989575 SGTC_2480 5767542 37.17 µM -0.0371190758340822 0.496941025674336 no 1661 0.485195031096399 2507 2867358 SGTC_2067 5224629 34.075 µM -0.037337953870341 0.497034901402132 no 1662 0.485107771883605 2518 2835000 SGTC_2295 7971645 200 µM -0.0380675410040896 0.497347818940567 no 1663 0.484816915534383 2512 2978226 YKL099C UTP11 SGTC_2471 5466956 24.79 µM -0.039060330019822 0.497773625490187 no 1664 0.484421144437034 2537 724419 SGTC_1853 st056710 91.2 µM -0.0397285706103706 0.498060234893687 no 1665 0.484154761799786 2510 269167 SGTC_2874 9043904 71.43 µM -0.039837319977019 0.498106877760727 no 1666 0.484111411398028 2540 4463428 SGTC_1675 st018485 24.5 µM -0.0406402130135937 0.498451241289725 no 1667 0.483791362637407 2547 3323024 SGTC_277 nystatin 15.5 µM -0.0417008587579965 0.498906157550758 no 1668 0.483368584684183 2482 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2274 7947094 46.08 µM -0.0418567929939099 0.49897303865803 no 1669 0.483306430192665 2476 2971028 SGTC_2702 st077768 96.8 µM -0.0421418128030818 0.499095285397129 no 1670 0.483192823981969 2530 6484119 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.0425981110770677 0.499290994689263 no 1671 0.483010950633628 2510 676296 Flavone; oxidizing agent. SGTC_562 3772-2733 112 µM -0.0428369305386397 0.499393425977822 no 1672 0.482915762342041 2492 2876874 YIL048W NEO1 SGTC_2401 5128683 200 µM -0.0429556286468015 0.499444336417624 no 1673 0.482868452195632 2499 708373 SGTC_336 4111-0029 111 µM -0.0437898988101137 0.499802160870865 no 1674 0.482535939471889 2524 3131175 SGTC_993 3909-8757 62.7 µM -0.0439204676641807 0.499858162810043 no 1675 0.482483900102668 2523 4288324 YLR208W SEC13 SGTC_2671 danthron 100 µM -0.0440052784418796 0.499894538776218 no 1676 0.482450098178476 2505 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3032 9089427 49.47 µM -0.0442511618923623 0.5 no 1677 0.48235210033633 2546 17173707 SGTC_3332 9141069 11.198 µM -0.0444323987645995 0.499922266169582 no 1678 0.482279868331291 2492 17332883 SGTC_212 3807-4682 38.772 µM -0.0445700837305277 0.499863212074621 no 1679 0.482224994339102 2535 3125501 YBL034C STU1 SGTC_1860 st056228 74.6 µM -0.0448542636842768 0.499741325212413 no 1680 0.4821117362089 2583 688679 SGTC_383 2324-0395 7.37 µM -0.045340614104841 0.499532726019493 no 1681 0.481917907667411 2544 3146421 SGTC_284 0988-0104 32.6 µM -0.0467219089556939 0.498940279611955 no 1682 0.481367434295153 2528 4666532 SGTC_2057 5236571 38.335 µM -0.0472718399171337 0.49870441119862 no 1683 0.481148285737167 2500 54684039 YBR257W POP4 SGTC_839 0122-0028 230 µM -0.0476589511253931 0.498538377339466 no 1684 0.480994024580249 2505 759448 SGTC_2115 tiliquinol 12.7705 µM -0.0481029626196052 0.498347938987446 no 1685 0.480817092555906 2559 71208 A bioactive hydroxyquinoline. SGTC_2954 9074818 52.69 µM -0.0483544609310696 0.498240070493776 no 1686 0.480716875866522 2539 16648742 SGTC_1187 1391-0724 117 µM -0.0497012538721973 0.497662428737954 no 1687 0.480180228625364 2515 6997986 SGTC_1029 k015-0030 64.7 µM -0.0497953547740564 0.497622068872143 no 1688 0.480142734223053 2609 2208316 SGTC_105 0111-0055 734.78 µM -0.0509150986204199 0.497141812850373 no 1689 0.479696587077762 2576 5179370 SGTC_2231 micatex 6.853 µM -0.0509513852221813 0.497126249660918 no 1690 0.479682129583057 2526 20737 An antifungal of unknown mechanism. SGTC_1809 st050081 57.6 µM -0.0510496754435112 0.497084093370103 no 1691 0.479642968421316 2574 5036894 SGTC_1752 st044819 83.042 µM -0.0521852484590349 0.496597053034301 no 1692 0.479190543470865 2525 441209 YML126C ERG13 SGTC_2282 7944268 200 µM -0.0524472162620116 0.496484697336007 no 1693 0.479086176361996 2536 2970414 SGTC_980 1473-0395 201 µM -0.053746667777434 0.49592737824807 no 1694 0.478568500500071 2497 768876 SGTC_2403 6032726 181.2 µM -0.0545132028529218 0.495598624253621 no 1695 0.478263144937882 2536 2881040 SGTC_1979 st071809 45.3 µM -0.054540593174593 0.495586877059572 no 1696 0.478252234012643 2616 4976333 SGTC_3236 9132701 49.47 µM -0.0556236408763154 0.495122381432823 no 1697 0.477820815480919 2512 24282524 SGTC_1372 2752-0194 270 µM -0.055924585573729 0.494993313938177 no 1698 0.477700942510107 2509 823334 SGTC_1917 st066507 28.5 µM -0.0560993473511214 0.494918363314914 no 1699 0.477631331929929 2489 3156428 SGTC_3087 9117406 49.47 µM -0.0564255450526008 0.494778466381074 no 1700 0.477501403679962 2605 42546093 SGTC_1765 st044815 90.4 µM -0.0568503198548328 0.494596293492365 no 1701 0.477332214637706 2558 645695 SGTC_2980 9014342 25.29 µM -0.0568662804082307 0.494589448522106 no 1702 0.477325857582202 2641 2996599 SGTC_3094 9117742 49.47 µM -0.0578888736400008 0.494150894439765 no 1703 0.476918572904737 2501 17149698 SGTC_517 1365-0151 113 µM -0.0580079932232638 0.494099808711642 no 1704 0.476871130789295 2644 768657 SGTC_3052 9092717 49.47 µM -0.0601327905313982 0.493188583335993 no 1705 0.476024937069891 2592 25237534 SGTC_1710 st031758 61.5 µM -0.0603103300075261 0.493112446569323 no 1706 0.475954237383846 2637 5394341 SGTC_389 tpck 16.7 µM -0.0603943411381844 0.493076418974248 no 1707 0.475920782774934 2540 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1360 1598-0022 39.8 µM -0.0606430881339415 0.492969745869714 no 1708 0.475821728641265 2579 761525 SGTC_2515 chrysin 20.77 µM -0.0616981197042825 0.492517309932489 no 1709 0.475401618688567 2572 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_589 1227-0070 34.1 µM -0.0629008665133578 0.492001540099565 no 1710 0.47492272241749 2590 2841384 SGTC_2064 5220758 200 µM -0.0631812132954339 0.491881321830338 no 1711 0.474811102252729 2611 788518 SGTC_440 fluspirilene 35.1 µM -0.0633061250508487 0.491827757425087 no 1712 0.474761369231844 2767 3396 An atypical antipsychotic. SGTC_892 0929-0076 29 µM -0.0635155940097758 0.491737933702822 no 1713 0.474677971045938 2524 5751038 SGTC_3170 9103054 49.47 µM -0.0641541347224377 0.491464119585511 no 1714 0.474423748654359 2571 16432970 SGTC_343 4130-2827 29.8 µM -0.0645398037214688 0.491298741911654 no 1715 0.474270207186337 2550 1118244 SGTC_2541 muurolladie-3-one 83.07 µM -0.0657660601526533 0.4907729243043 no 1716 0.473782038894074 2669 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2388 9080168 200 µM -0.066990190688328 0.490248034271266 no 1717 0.473294756177716 2521 15943073 SGTC_101 0490-5701 117.494 µM -0.0677851262983644 0.489907185999845 no 1718 0.47297834201086 2535 4661669 SGTC_1130 3454-2858 15.9 µM -0.0695691466257626 0.489142270440125 no 1719 0.47226829742317 2624 715628 YIL048W NEO1 SGTC_2821 7996764 71.43 µM -0.0696968580914537 0.489087514441678 no 1720 0.472217471291068 2591 2987135 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.069708463373849 0.489082538713607 no 1721 0.472212852686538 2694 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2871 9038510 12.99 µM -0.0702519774827836 0.488849510677247 no 1722 0.471996552216823 2526 4945164 SGTC_2972 9093619 59.92 µM -0.0703157412871842 0.488822172620832 no 1723 0.471971176891538 2538 25236256 SGTC_1647 st011722 22.4 µM -0.0703391203137106 0.488812149123746 no 1724 0.471961873046021 2580 2854783 SGTC_2287 7945887 168.79 µM -0.0708192840997025 0.488606285823514 no 1725 0.471770791933294 2561 1245853 SGTC_775 4577-0580 57.3 µM -0.0712768425459217 0.488410117060506 no 1726 0.471588712657719 2723 2006902 SGTC_2266 7929956 200 µM -0.071359404203789 0.488374720746811 no 1727 0.471555858979414 2524 2967153 SGTC_2411 st077133 39.94 µM -0.0716797723830453 0.48823737150903 no 1728 0.471428377023624 2815 1403142 YNL221C POP1 SGTC_2428 5615643 7.78 µM -0.071951927039213 0.488120693617426 no 1729 0.471320082650188 2583 2253075 SGTC_3148 9097893 49.47 µM -0.0729486893822515 0.487693371347334 no 1730 0.470923474299521 2563 17174100 SGTC_3282 9108498 15.4605 µM -0.0738683665929793 0.487299108786884 no 1731 0.470557563430556 2612 16459645 SGTC_1568 digitonin 820 nM -0.0740339898621157 0.487228107950228 no 1732 0.470491669731484 2552 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2933 9026794 32.47 µM -0.0741473315574659 0.487179519870655 no 1733 0.47044657687406 2582 17586027 SGTC_2767 sibutramine 71.45 µM -0.0760081666863296 0.486381832302962 no 1734 0.469706300459919 2586 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1148 3909-7663 27.7 µM -0.0764993650394974 0.486171278373259 no 1735 0.469510909560864 2683 4084526 SGTC_857 0438-0306 1.35 µM -0.0770157053246725 0.485949951421685 no 1736 0.469305525516913 2603 4686136 SGTC_3058 9093861 49.47 µM -0.0771536995210055 0.485890801557297 no 1737 0.46925063711493 2598 17217477 SGTC_2508 celastrol 40.54 µM -0.0772410173411951 0.485853373786831 no 1738 0.46921590598787 2518 122724 Celastrol is a natural product and antioxidant. SGTC_1712 st032288 53.4 µM -0.0772892009075521 0.485832720513527 no 1739 0.469196740818541 2549 2883011 SGTC_1157 4092-0394 27.6 µM -0.0787452583771985 0.485208618165728 no 1740 0.468617623121211 2694 3659885 SGTC_2691 st077356 60.2 µM -0.0802416249756631 0.484567276088954 no 1741 0.468022542465951 2648 2839272 SGTC_2306 7482397 179.52 µM -0.0803387918772121 0.484525631759451 no 1742 0.467983903225887 2600 891448 SGTC_1888 azatryptophan 97.5 µM -0.0805072816895837 0.484453419861668 no 1743 0.467916902542412 2663 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1549 4'-methoxyflavonol 74.6 µM -0.081274834073881 0.48412446631569 no 1744 0.467611693632986 2534 97141 SGTC_2687 chenodiol 100 µM -0.081665958933234 0.483956844231461 no 1745 0.467456174371799 2597 5702181 A cholesterol synthesis inhibitor. SGTC_3347 9188721 44.724 µM -0.0824048913534168 0.483640172065364 no 1746 0.467162373271787 2622 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2674 ligustilide 100 µM -0.0831823059687578 0.483307019358272 no 1747 0.466853290883437 2621 5319022 A signalling regulator. SGTC_52 0329-0193 875 nM -0.083762150625188 0.483058540716306 no 1748 0.466622770824933 2756 3739292 SGTC_967 1306-0166 352 µM -0.0839469304293765 0.482979359102192 no 1749 0.466549313065315 2569 4437607 SGTC_586 0957-0265 8.15 µM -0.084208200216418 0.482867401241241 no 1750 0.466445449259052 2543 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1781 st038725 66.3 µM -0.0844560566646292 0.482761192437431 no 1751 0.466346919832427 2563 4270275 YIL048W NEO1 SGTC_248 streptozotocin 5.23457 mM -0.0850041917533548 0.482526315785618 no 1752 0.466129029118194 2653 5300 DNA alkylating agent. SGTC_2376 9072922 81.32 µM -0.0853900535295129 0.482360977107425 no 1753 0.465975650207813 2683 17087968 SGTC_2563 tomatine 8.54 µM -0.085658200561901 0.482246080038279 no 1754 0.465869065533412 2533 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_817 1391-0715 46 µM -0.0861544492999967 0.482033448631629 no 1755 0.465671820102128 2620 1353946 SGTC_1621 st003705 32.4 µM -0.0869593552721421 0.481688575446389 no 1756 0.465351909733941 2555 24207032 SGTC_259 usnic acid 108.925 µM -0.0871042522647111 0.481626493757796 no 1757 0.465294322708338 2715 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2379 9035213 200 µM -0.0871622468833193 0.481601645859234 no 1758 0.465271273864975 2548 646551 SGTC_1510 1123-0200 71.5 µM -0.0879294349923069 0.481272949498906 no 1759 0.464966380732603 2717 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_532 1548-0774 215 µM -0.0879335594235891 0.481271182449478 no 1760 0.464964741671414 2739 5932993 SGTC_2800 7887935 81.82 µM -0.0884624916017586 0.481044572618725 no 1761 0.464754547395723 2640 2961002 SGTC_188 3229-0966 278.469 µM -0.0884820972101144 0.481036173126797 no 1762 0.464746756440615 2584 5722370 SGTC_825 1988-2224 89.6 µM -0.0897492932691791 0.480493295319753 no 1763 0.464243221800743 2566 1180859 SGTC_2279 7948423 32.93 µM -0.0897975017851023 0.480472643080433 no 1764 0.464224066729075 2554 1247112 SGTC_2566 crystal violet carbinol 226 nM -0.0902785575403482 0.480266564557859 no 1765 0.46403292958303 2724 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1783 st039459 87.517 µM -0.0910492366880237 0.479936425859479 no 1766 0.463726734138033 2765 729761 SGTC_2389 9091542 195.52 µM -0.0915259969035766 0.479732201185236 no 1767 0.463537325191722 2628 3626624 YOL127W RPL25 SGTC_1237 0330-0133 46.1 µM -0.0916156710710673 0.479693789014084 no 1768 0.463501700050689 2582 X1237 YHR072W ERG7 SGTC_994 3910-0338 138 µM -0.0923665495060373 0.479372155649141 no 1769 0.463203407705692 2674 3479481 SGTC_3252 9135871 49.47 µM -0.0928811373923087 0.479151743381058 no 1770 0.462998995570344 2688 17682838 SGTC_1941 st076221 61.8 µM -0.0929453581240977 0.479124236306024 no 1771 0.46297348555549 2723 2828568 SGTC_2395 5646831 180.19 µM -0.0934469645717982 0.478909391263828 no 1772 0.46277424069209 2671 6808628 SGTC_623 k072-0108 16.9 µM -0.0937578208619277 0.47877625024791 no 1773 0.462650769054493 2652 5382803 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0942686636340677 0.478557459357492 no 1774 0.46244787091699 2606 2374 Ca(2+)-ATPase inhibitor. SGTC_1258 0671-0043 57.1 µM -0.0946345634256274 0.478400750642714 no 1775 0.462302547690469 2636 4298767 SGTC_229 benomyl 22.8748 µM -0.0949002159694389 0.478286978225703 no 1776 0.462197042488079 2650 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1090 efavirenz 20.7 µM -0.0964434110456898 0.477626101212747 no 1777 0.4615842078804 2612 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM -0.0967164619981299 0.477509172837987 no 1778 0.46147578316787 2601 16667744 Haematoxylin. SGTC_2709 st078560 56 µM -0.0967260963206871 0.47750504717562 no 1779 0.461471957565441 2614 17250903 SGTC_1812 st052057 4.327 µM -0.0968040964807066 0.477471645608743 no 1780 0.461440985347636 2568 3645418 SGTC_1862 st057513 3.81 µM -0.0993940560500839 0.476362653184588 no 1781 0.460412700990361 2601 5393163 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0994479256016517 0.476339588744095 no 1782 0.460391316100053 2590 688664 SGTC_1412 3909-8563 178 µM -0.100067757361678 0.476074211289755 no 1783 0.460145266356785 2605 23767530 SGTC_475 α-linolenic acid 10 µM -0.100130604274337 0.47604730433095 no 1784 0.460120319362258 2782 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_743 1275-0778 158 µM -0.100513743202093 0.475883271538468 no 1785 0.459968236297457 2677 2849257 YMR203W TOM40 SGTC_2544 sphondin 68.51 µM -0.100780871717393 0.475768908556008 no 1786 0.459862205838985 2788 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2011 4012611 177 µM -0.100882913691482 0.475725222902049 no 1787 0.459821703400963 2590 2049887 SGTC_3295 9122362 53.5725 µM -0.102472156233125 0.475044883034646 no 1788 0.459190956297759 2657 4730473 SGTC_262 fenpropimorph 62.5 µM -0.102629443233674 0.474977553865294 no 1789 0.459128536949346 2586 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2330 7979373 200 µM -0.102988350646461 0.474823920592599 no 1790 0.458986108312677 2618 1863007 SGTC_495 decylubiquinone 155 µM -0.10317281491974 0.474744960596866 no 1791 0.458912907650572 2636 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_644 1498-1197 63.3 µM -0.10358098072925 0.474570248611771 no 1792 0.45875094082139 2670 6741615 SGTC_3062 9077494 49.47 µM -0.105201491571059 0.473876650980663 no 1793 0.458107963594627 2645 16459633 SGTC_400 oxethazaine 37.5 µM -0.105211503281989 0.473872366095003 no 1794 0.458103991542919 2651 4621 A local anesthetic. SGTC_2361 9034121 116 µM -0.105523750528812 0.473738729742111 no 1795 0.457980112500382 2635 6496917 SGTC_54 0159-0055 9 µM -0.106554774301831 0.473297490695721 no 1796 0.457571099556825 2601 3319099 SGTC_1679 SEC14.276 6.7 µM -0.108119321478585 0.472627986633109 no 1797 0.456950520836699 2746 1005053 YMR079W SEC14 SGTC_2546 rhodinyl acetate 100 µM -0.108768349112725 0.472350276052319 no 1798 0.456693114294293 2612 6708682 SGTC_3188 9110789 49.47 µM -0.109289477978049 0.472127301432869 no 1799 0.456486445980964 2692 849217 SGTC_1265 0819-1001 68.8 µM -0.110158985497021 0.471755286046527 no 1800 0.456141644541562 2579 3106768 SGTC_355 1311-2252 105 µM -0.110464305471435 0.471624661920171 no 1801 0.45602057834724 2643 5338538 SGTC_2285 7945142 200 µM -0.111165987836231 0.471324474855343 no 1802 0.455742361098721 2695 2970608 SGTC_1514 1189-1591 158 µM -0.112078852594901 0.470933966159585 no 1803 0.455380442474614 2794 767698 YMR146C TIF34 SGTC_721 1187-1332 279 µM -0.11263746291026 0.470695015512099 no 1804 0.455158991463565 2583 25730 SGTC_1787 fluconazole 80 µM -0.114990333025092 0.469688670719659 no 1805 0.454226392171927 2631 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_736 0958-0254 92.6 µM -0.115018940692715 0.469676436127952 no 1806 0.454215054588044 2694 6812352 SGTC_3104 9120930 49.47 µM -0.118034922399182 0.46838675930868 no 1807 0.453019993606478 2689 17014836 SGTC_2068 5226020 147 µM -0.118429449735401 0.468218078032482 no 1808 0.45286369622772 2643 1810509 SGTC_3217 9129673 49.47 µM -0.119257691768557 0.46786397941191 no 1809 0.452535600649251 2740 17248312 SGTC_1347 1493-0251 600 nM -0.119923488010889 0.467579349721177 no 1810 0.45227187900336 2707 3986378 SGTC_3055 9094636 49.47 µM -0.120545237073242 0.467313565282311 no 1811 0.4520256234394 2741 25236176 SGTC_2769 toremifene 3.73 µM -0.122035007966447 0.466676779572094 no 1812 0.451435646557485 2760 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_858 0438-0351 2.77 µM -0.122490382545353 0.466482151805311 no 1813 0.451255331127588 2633 2799119 SGTC_890 0929-0006 47.2 µM -0.122744167490277 0.466373687220576 no 1814 0.451154843842702 2620 1378169 SGTC_1179 1021-1431 9.29 µM -0.123911285173696 0.465874907657946 no 1815 0.45069275876881 2706 2840958 SGTC_983 1491-0821 12.2 µM -0.12420013764452 0.465751471872873 no 1816 0.450578406629378 2750 46495113 SGTC_276 colchicine 750 µM -0.124289811067359 0.465713152256338 no 1817 0.450542907169013 2738 2833 A microtubule depolymerizer. SGTC_375 3970-0961 9.27 µM -0.125439261166429 0.465221992780973 no 1818 0.450087903824872 2693 2898222 SGTC_553 k007-0256 45.7 µM -0.126086457205903 0.46494546948823 no 1819 0.449831743748474 2683 6287000 SGTC_1199 1638-0010 4.46 µM -0.12656610580775 0.464740544026691 no 1820 0.449641912397985 2631 3111136 SGTC_1704 st028805 70.8 µM -0.126953952349303 0.464574846988323 no 1821 0.449488422130951 2667 2876101 SGTC_2620 irigenin 100 µM -0.12697899066825 0.464564150248512 no 1822 0.449478513475793 2730 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_600 1495-0418 41.6 µM -0.127319341804696 0.464418749757464 no 1823 0.449343826169009 2637 5377768 SGTC_1421 4029-0249 71.4 µM -0.127439418567417 0.464367453220394 no 1824 0.449296309530193 2738 2894095 SGTC_1843 st055809 45.5 µM -0.127671416747487 0.464268345770749 no 1825 0.449204505536642 2761 16413835 SGTC_2927 9011802 47.9 µM -0.128989710996178 0.463705225087178 no 1826 0.448682895124237 2730 43912568 SGTC_2012 4023501 200 µM -0.129194827885678 0.46361761415837 no 1827 0.44860174433112 2695 3477460 SGTC_1883 5-benzylidenerhodanine 20 µM -0.129851926846993 0.46333696145621 no 1828 0.448341789489551 2724 1273210 SGTC_1483 3453-0561 55.9 µM -0.132102754790675 0.462375752339364 no 1829 0.447451508501418 2733 4546991 SGTC_3165 9101544 49.47 µM -0.132502134163549 0.462205221399332 no 1830 0.447293567545538 2736 5002184 SGTC_3312 9133330 71.43 µM -0.13334117015096 0.461846984211279 no 1831 0.446961784607521 2793 17617324 SGTC_735 3076-0345 636 µM -0.135408892245277 0.46096427643821 no 1832 0.446144296945631 2749 2888990 SGTC_2771 fluoxetine 41.05 µM -0.136075770844786 0.460679627665411 no 1833 0.445880690704745 2792 3386 A selective serotonin reuptake inhibitor. SGTC_1209 2323-2347 50.3 µM -0.137125498976694 0.460231605239824 no 1834 0.445465798788867 2633 5412760 SGTC_1203 3992-3522 103 µM -0.137897966994319 0.459901949236034 no 1835 0.445160528581308 2951 5322312 SGTC_88 0180-0332 8.668 µM -0.138145345869597 0.459796384427006 no 1836 0.445062774246389 2633 3101745 SGTC_1661 st013063 9.66 µM -0.138777346121043 0.45952670174758 no 1837 0.444813047958332 2649 721395 SGTC_1000 4048-0884 8.67 µM -0.139050634147145 0.459410091972945 no 1838 0.444705068695799 2783 13040088 SGTC_150 3970-0969 77.2 µM -0.139922054379154 0.459038287425917 no 1839 0.444360787915279 2777 6615640 SGTC_217 ketoconazole 989 nM -0.139951182441858 0.459025860116906 no 1840 0.444349280721316 2718 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_599 1935-0052 86.5 µM -0.140022837208056 0.458995289221535 no 1841 0.444320973329718 2654 9557311 SGTC_732 3970-1727 52.7 µM -0.140521733537031 0.458782446085872 no 1842 0.444123890988683 2763 1275699 SGTC_1892 st058411 7.36 µM -0.141300313449691 0.458450305737266 no 1843 0.443816351001225 2788 3934738 SGTC_245 methotrexate 289.6 µM -0.141892635732244 0.458197641868885 no 1844 0.443582405648056 2721 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1617 st002906 78 µM -0.142108587667383 0.45810552855915 no 1845 0.443497117522359 2648 5150859 SGTC_82 0054-0107 293.755 µM -0.143252274786929 0.457617731680302 no 1846 0.443045473098073 2738 3104697 SGTC_170 4197-0004 226 µM -0.144479862966014 0.457094221000856 no 1847 0.442560778316821 2801 218692 SGTC_2270 7924575 90.91 µM -0.144961292479292 0.4568889334226 no 1848 0.442370716520099 2884 1262135 SGTC_2479 5617353 43.85 µM -0.146797690586404 0.456105976359065 no 1849 0.441645853790923 2791 2731746 SGTC_128 0906-2981 13.371 µM -0.148955722887016 0.45518610704112 no 1850 0.440794285557287 2779 6740226 SGTC_65 0798-0905 34.986 µM -0.149093620259603 0.455127335885058 no 1851 0.440739879961013 3052 3602145 SGTC_2273 7815444 169.05 µM -0.149346936348911 0.455019376421356 no 1852 0.440639940342153 2819 2824616 SGTC_2926 9010726 65.15 µM -0.149374451704827 0.45500764999512 no 1853 0.440629085064253 2776 2994293 SGTC_173 1273-0061 2.693 µM -0.149877232941397 0.454793382846653 no 1854 0.440430737142686 2782 2847414 YPL266W DIM1 SGTC_2000 st075254 36.4 µM -0.150199129120503 0.454656209258508 no 1855 0.440303756481199 2682 17234175 SGTC_197 4544-0043 41.561 µM -0.15065013467767 0.454464025798073 no 1856 0.440125855460013 2685 896523 SGTC_1640 st009078 66.4 µM -0.151127840422943 0.454260476421461 no 1857 0.439937435620571 2793 690618 SGTC_1763 st044482 94.5 µM -0.15197413296572 0.453899902536729 no 1858 0.439603668775044 2799 88505 SGTC_1468 k284-1086 134 µM -0.153035221832428 0.453447865616561 no 1859 0.439185249711253 2701 15996457 SGTC_3233 9132340 49.47 µM -0.154099794942611 0.452994404970932 no 1860 0.438765524980621 2690 17682950 SGTC_2823 7987624 58.44 µM -0.155046767903832 0.452591088231433 no 1861 0.438392223810145 2832 2239440 SGTC_1467 k284-1082 293 µM -0.155293949622992 0.452485821320487 no 1862 0.438294792626949 2777 3334705 SGTC_139 0099-0334 718.624 µM -0.155502935581339 0.45239682338649 no 1863 0.438212419917026 2674 97690 SGTC_1150 3909-7983 10.9 µM -0.155693109740571 0.452315838649227 no 1864 0.438137464284449 2707 23965914 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.156186901635231 0.452105569052881 no 1865 0.437942850504919 2649 2333 A French combination drug. SGTC_2947 9072639 7.68 µM -0.157269857344535 0.451644465102405 no 1866 0.437516087482508 2754 16488146 SGTC_759 3486-0358 89.3 µM -0.157330793768226 0.451618521351919 no 1867 0.437492076271262 2697 875103 SGTC_2303 7774051 200 µM -0.157377239510639 0.451598747163945 no 1868 0.437473775080533 2815 2953184 SGTC_1817 st052116 64.4 µM -0.157450702805014 0.451567470548964 no 1869 0.437444828335238 2819 4361398 SGTC_821 1114-0266 29.2 µM -0.157733060838906 0.451447260886602 no 1870 0.43733357390392 2753 3123235 SGTC_1622 st003707 19.4 µM -0.158088961241288 0.451295748016997 no 1871 0.437193349441588 2800 10140899 SGTC_2958 9077254 16.72 µM -0.158261039977692 0.45122249370811 no 1872 0.43712555339102 2859 16457351 SGTC_1505 k297-0037 20.6 µM -0.160083975392921 0.450446568455548 no 1873 0.436407462080384 2713 4089396 SGTC_897 1000-0139 31.4 µM -0.160619122055558 0.450218821216169 no 1874 0.436196696612074 2823 6151020 SGTC_184 1494-0393 24.714 µM -0.162803598913626 0.449289324326059 no 1875 0.435336537276725 2678 3090647 SGTC_1486 3970-0793 4.53 µM -0.162896919420497 0.449249622525711 no 1876 0.435299798189267 2788 2844330 SGTC_3194 9111903 49.47 µM -0.163284854333968 0.4490845869259 no 1877 0.435147079175934 2860 17087251 SGTC_2877 9040724 71.43 µM -0.165531124785699 0.448129150699151 no 1878 0.434262976847918 2884 6463895 SGTC_270 tamoxifen 5.46 µM -0.166297928396841 0.447803064467787 no 1879 0.433961248124027 2859 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2612 dictamnine 15.46 µM -0.166571784360345 0.447686614685994 no 1880 0.433853498151871 2809 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_260 nsc-65238 3.989 µM -0.16667412897697 0.447643096585031 no 1881 0.433813231421675 2817 3246252 SGTC_1939 st074455 53.6 µM -0.166683852930401 0.447638961881647 no 1882 0.433809405640056 2938 1644229 SGTC_725 1497-0963 19 µM -0.167206742456038 0.44741663343093 no 1883 0.433603689697164 2802 3549977 SGTC_3300 9124615 50.48 µM -0.167638382204395 0.447233116101952 no 1884 0.433433886920455 2878 24824903 SGTC_904 1141-0088 396 µM -0.167659069401973 0.447224320950578 no 1885 0.433425749091318 2750 1378119 SGTC_3033 9090887 49.47 µM -0.168607141156737 0.446821276651425 no 1886 0.433052831578501 2719 19325384 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.16867545878625 0.446792235574727 no 1887 0.43302596160666 2712 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_163 TUB2.036 7.546 µM -0.169174399658412 0.446580149931219 no 1888 0.43282973282401 2736 15992207 YJR013W GPI14 SGTC_3255 9139072 49.47 µM -0.169989109285607 0.446233872797639 no 1889 0.432509350764908 2767 17646060 SGTC_2504 purpurogallin 52.29 µM -0.171021725163786 0.445795037623503 no 1890 0.432103341522365 2711 5281571 An antioxidant. SGTC_275 trichlorophene 5.69 µM -0.171282800744925 0.445684097714601 no 1891 0.432000701815558 2802 62616 SGTC_131 0141-0277 33.849 µM -0.17207998461978 0.445345373481565 no 1892 0.431687323996665 2868 1547771 SGTC_489 paxilline 115 µM -0.172151886213714 0.445314824379504 no 1893 0.431659061154274 2773 105008 A toxic potassium channel blocker. SGTC_350 k064-0020 19.8 µM -0.172393890899994 0.445212005320291 no 1894 0.431563937318126 2890 2790705 SGTC_2004 4023728 41.89 µM -0.172471741478605 0.445178930201589 no 1895 0.431533337738868 2797 360084 YDR527W RBA50 SGTC_706 4262-0057 46.9 µM -0.172741116364545 0.445064488188071 no 1896 0.431427461695076 2710 883298 SGTC_3203 9113543 49.47 µM -0.172767481123917 0.445053287552503 no 1897 0.431417099462751 2896 17018012 SGTC_2526 patulin 37.61 µM -0.17281365092294 0.445033673176369 no 1898 0.431398953301076 2852 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1452 4194-0072 190 µM -0.172984488433036 0.44496109722399 no 1899 0.431331810125191 2884 1343545 SGTC_1489 4065-0444 182 µM -0.173618847770393 0.444691622026196 no 1900 0.431082509303008 2729 2877968 SGTC_1222 0366-0074 1.18 µM -0.17422875830225 0.44443255675611 no 1901 0.430842842656616 2841 286520 SGTC_395 anisomycin 6.25 µM -0.175027847091361 0.444093172171265 no 1902 0.430528876253469 2773 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_776 4476-4378 112 µM -0.175361587844788 0.443951439759731 no 1903 0.430397760654098 2806 2892008 SGTC_682 0kpi-0099 17 µM -0.176065520454934 0.443652518475308 no 1904 0.430121234212074 2816 1714895 YML126C ERG13 SGTC_35 0133-0054 64.071 µM -0.177239533296095 0.443154051491449 no 1905 0.429660122060728 2751 99677 SGTC_1388 3346-4487 254 µM -0.178562897264353 0.442592280298501 no 1906 0.429140464940713 2799 3345614 SGTC_700 3453-2283 142 µM -0.179267217207421 0.442293341768953 no 1907 0.428863943360573 2901 565664 SGTC_49 0717-0965 32.132 µM -0.180840296442493 0.441625789670843 no 1908 0.428246466272738 3011 5889349 YGL099W LSG1 SGTC_385 1494-0393 12.4 µM -0.181613240395674 0.441297843700636 no 1909 0.427943128661934 2770 3090647 SGTC_2940 9060638 45.86 µM -0.182049724264204 0.441112669350576 no 1910 0.42777185176395 2837 4027022 SGTC_1944 st076371 56.9 µM -0.183363726486644 0.440555293612947 no 1911 0.427256317682888 2739 24208455 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.183605387585434 0.440452798176992 no 1912 0.427161518148328 2740 65057 A dermal irritant. YDR527W RBA50 SGTC_1762 st045503 25.4615 µM -0.183888757376242 0.44033261796521 no 1913 0.427050362362174 2786 4645554 SGTC_458 nppb 133 µM -0.184652201842894 0.440008860242512 no 1914 0.42675091937923 2885 4549 A chloride channel blocker. SGTC_368 fentichlor 4.58 µM -0.18514276920544 0.439800844035284 no 1915 0.42655852823273 2813 7329 A pesticide. SGTC_964 1287-0107 19.4 µM -0.185634715997794 0.439592259593718 no 1916 0.426365613647159 2868 51516812 YPR165W RHO1 SGTC_1945 st075991 56.6 µM -0.186192229006459 0.439355895482056 no 1917 0.426147008880335 2791 1084980 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.186369069960743 0.439280926219035 no 1918 0.426077673037119 2880 5377381 SGTC_2878 9043973 25.97 µM -0.187761147329111 0.438690850638983 no 1919 0.425531946975327 2910 6465167 SGTC_1053 3366-3204 134 µM -0.18801222619311 0.438584437465877 no 1920 0.42543353348911 2789 3632071 YPR165W RHO1 SGTC_2367 9070478 135.38 µM -0.188222962661882 0.438495125782574 no 1921 0.425350936292546 2727 572802 SGTC_2 0422-0095 29 µM -0.188511235251849 0.438372958787702 no 1922 0.425237954474117 2702 6790840 SGTC_1439 4092-1168 46 µM -0.19215285289067 0.436830187687774 no 1923 0.423811237789027 2757 2886240 SGTC_2487 5918373 44.05 µM -0.193016187517137 0.436464575960654 no 1924 0.423473145331167 2729 2876279 SGTC_1062 mesoridazine 14.2 µM -0.193703476103088 0.436173556378306 no 1925 0.423204034930589 2734 4078 A neuroleptic. SGTC_1402 3909-7673 35.9 µM -0.194648366565074 0.435773516500097 no 1926 0.422834118064437 2713 5328014 SGTC_1987 st072290 61.9 µM -0.19527491771645 0.435508288680199 no 1927 0.422588865918756 2806 54697379 SGTC_1718 roemerine 11.9335 µM -0.195498891593729 0.435413484453534 no 1928 0.422501202659996 2868 235224 An aporphine alkaloid with mutagenic activity. SGTC_2286 7945697 125 µM -0.199208662396314 0.433843747298739 no 1929 0.421049761805966 2825 1245733 SGTC_1835 st008666 49.2 µM -0.199443033594554 0.433744611196831 no 1930 0.420958100324322 2775 690455 SGTC_2949 9072542 2.23 µM -0.201020130880996 0.433077627344436 no 1931 0.42034141659392 2869 16457352 SGTC_978 1416-0512 87.4 µM -0.201067201769209 0.433057723107738 no 1932 0.420323013718704 2821 6814003 SGTC_1920 st075728 45.7 µM -0.203335866730553 0.432098605367786 no 1933 0.419436261721795 2950 3400306 SGTC_1981 st071826 47 µM -0.204935521056985 0.431422563704438 no 1934 0.418811251182314 2864 11838600 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.205168038174984 0.431324314608357 no 1935 0.418720420040658 2869 616764 SGTC_2442 5158906 48.48 µM -0.205800073386227 0.431057272370422 no 1936 0.418473541936631 2925 1893835 SGTC_122 0236-0016 402.397 µM -0.207038243322526 0.430534222602916 no 1937 0.417989995824534 2812 6808838 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.207587682148309 0.430302157858244 no 1938 0.417775461539392 2836 75037 A free radical scavenger. SGTC_2505 galangin 7.89 µM -0.207964758444417 0.430142907255745 no 1939 0.417628242207835 2740 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3013 9080133 71.4286 µM -0.208223014980018 0.430033844348002 no 1940 0.417527419526231 2971 17050193 SGTC_1643 st009866 20.2 µM -0.208971887225503 0.429717622409642 no 1941 0.417235092421101 2870 3156273 YOR207C RET1 SGTC_2850 9015429 58.44 µM -0.209154423342494 0.429640550768837 no 1942 0.417163845199823 2840 6457570 SGTC_900 1112-0045 141 µM -0.210560742775433 0.429046855139379 no 1943 0.416615024098995 2801 56211 YIL048W NEO1 SGTC_679 0422-0091 41.4 µM -0.210798763725516 0.428946387411923 no 1944 0.416522151636524 2760 627384 YHR062C RPP1 SGTC_1048 3161-0300 24.5 µM -0.21139286268536 0.428695640624613 no 1945 0.416290362830985 2774 2165101 SGTC_1172 0370-0043 85 µM -0.211946448467495 0.428462018822449 no 1946 0.416074406513263 2935 376585 SGTC_45 0kpi-0036 14.9 µM -0.213326564572845 0.427879697700038 no 1947 0.415536127435272 2901 2795021 SGTC_148 3253-0744 288.01 µM -0.213342456870379 0.427872993074564 no 1948 0.415529929971 2766 6893655 SGTC_3016 9080866 49.47 µM -0.213363768422775 0.427864002212336 no 1949 0.415521619211644 2818 17066299 SGTC_1044 1222-0021 1.78 µM -0.213655353059139 0.427740993009066 no 1950 0.41540791520845 2909 4306703 SGTC_1633 st005664 67.9 µM -0.214450916371308 0.427405408855225 no 1951 0.415097719783509 2765 2063822 SGTC_1245 0418-0076 17.2 µM -0.218704794078631 0.425611937091349 no 1952 0.41344000712904 2977 6790114 SGTC_1060 3448-7350 82 µM -0.218723821726479 0.425603918297413 no 1953 0.413432595601499 2903 570178 SGTC_3329 9141233 27.5565 µM -0.218837509729743 0.42555600756895 no 1954 0.413388313221315 2940 4909101 YNL103W MET4 SGTC_2998 9066762 71.4286 µM -0.219119311440177 0.42543725461423 no 1955 0.41327855396805 2947 4945196 SGTC_2540 epiandrosterone 100 µM -0.219158953863964 0.425420549598173 no 1956 0.413263114141054 2819 441302 A steroid. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.219738453260503 0.425176368255678 no 1957 0.413037427564312 2897 16725076 SGTC_1071 trifluoperazine 6.31 µM -0.219997299839204 0.425067308375894 no 1958 0.412936628804861 2954 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_292 k038-0015 474 µM -0.221437739076601 0.424460512801198 no 1959 0.412375805077379 2917 46368540 SGTC_806 3966-4455 5.86 µM -0.222715466390553 0.423922410569087 no 1960 0.411878481618951 2797 714982 SGTC_1665 st014639 11.4 µM -0.222979022288304 0.423811434217151 no 1961 0.41177591664417 2830 981133 YIL048W NEO1 SGTC_1565 sinapyl alcohol 95.1 µM -0.223412318583325 0.423628997852079 no 1962 0.411607308881943 2876 5280507 A phenol propionate derived from cinnamic acid. SGTC_1930 st074634 34.3 µM -0.225565575605048 0.422722627635851 no 1963 0.410769658751126 2786 684253 YOR116C RPO31 SGTC_91 0417-1751 58.384 µM -0.226058929644167 0.422515017590885 no 1964 0.410577793574777 2767 6795624 SGTC_25 0118-0223 35.662 µM -0.226426175008841 0.422360489750548 no 1965 0.410434985897847 2947 5333628 SGTC_2506 ethyl hematommate 54.16 µM -0.2270096797604 0.422114989850688 no 1966 0.410208107645816 2864 3940691 An allergen. SGTC_3059 1327-0034 3 µM -0.227345008980598 0.421973919354989 no 1967 0.410077738568326 2828 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2575 plumbagin 510 nM -0.227416386443207 0.421943892681795 no 1968 0.410049989766952 2766 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_433 pimozide 108 µM -0.228169318725083 0.421627180996551 no 1969 0.409757306230423 2766 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3143 9086658 49.47 µM -0.228985337947307 0.421283989811666 no 1970 0.409440156006439 2880 25236626 SGTC_3110 9122132 49.47 µM -0.229158789508074 0.421211049414956 no 1971 0.409372750761555 2965 918317 SGTC_2684 capsaicin 100 µM -0.229484620561669 0.421074037226443 no 1972 0.409246136361604 2900 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2044 5102272 200 µM -0.230180654897935 0.420781386332569 no 1973 0.408975696724642 2910 592666 SGTC_1706 st031321 9.9705 µM -0.230387176379133 0.420694561823016 no 1974 0.408895462468599 2913 6103185 SGTC_536 3852-0578 10.6 µM -0.231440641316395 0.420251730594686 no 1975 0.408486247441337 2981 2869208 SGTC_2240 6690706 185.951 µM -0.231847549867082 0.420080710778448 no 1976 0.408328211823691 2752 805876 SGTC_1118 chelidonine 707.474 nM -0.234109824082042 0.419130174328224 no 1977 0.407449859663408 2934 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2793 7325131 81.82 µM -0.234192625223754 0.419095392810573 no 1978 0.407417720031142 2899 4176441 SGTC_883 0850-0245 24.6 µM -0.234210551182685 0.419087862900346 no 1979 0.407410762072334 3027 6823229 YPR165W RHO1 SGTC_1503 4585-0012 61.3 µM -0.23792327909205 0.417528951218862 no 1980 0.405970299889754 3018 2922052 SGTC_2764 methyldopa 94.69 µM -0.238116359170811 0.417447915380151 no 1981 0.405895423413919 2981 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2718 lomofungin 53.02 µM -0.238296093547529 0.417372483892354 no 1982 0.405825725496474 2985 5351222 A RNA synthesis inhibitor. SGTC_198 3454-2873 16.191 µM -0.238844639783031 0.417142287098551 no 1983 0.405613027114382 2823 710957 SGTC_2371 9071574 200 µM -0.239040848397827 0.417059955272097 no 1984 0.405536954137462 2929 45596039 SGTC_58 0957-0393 9 µM -0.239600365288159 0.416825194294837 no 1985 0.405320040781261 2872 6997992 SGTC_2180 6301957 200 µM -0.240281741549799 0.416539343863687 no 1986 0.405055924289894 2928 845462 SGTC_1329 1447-1697 50.6 µM -0.240637668410243 0.416390043245313 no 1987 0.404917976360804 2938 2840515 SGTC_2880 9042983 58.44 µM -0.241172811241084 0.416165589622831 no 1988 0.404710591256303 2981 6464714 SGTC_220 paclitaxel 373.376 µM -0.241584536095403 0.415992919498521 no 1989 0.404551052811725 2944 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2485 5633444 17.78 µM -0.241637320431721 0.4159707838531 no 1990 0.404530600661296 2930 5724239 SGTC_1605 st000082 49.1 µM -0.242272376621997 0.415704487531581 no 1991 0.40428455826587 2944 1114022 SGTC_472 calcifediol 10 µM -0.243596999738762 0.415149161755758 no 1992 0.403771476087332 2903 5283731 A vitamin D metabolite. SGTC_1771 st048882 4.1505 µM -0.243871477130226 0.415034112925152 no 1993 0.403665180138991 2818 4580403 SGTC_1145 3546-0597 10.2 µM -0.245765205091747 0.414240544648564 no 1994 0.402931996685664 2882 875334 SGTC_2751 anetholtrithion 17.25 µM -0.245994880273064 0.414144322806231 no 1995 0.402843097852013 2980 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2517 totarol 10 µM -0.247305465135152 0.413595355328068 no 1996 0.402335914782684 2914 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_124 0136-0217 7.121 µM -0.248228393914112 0.41320886743128 no 1997 0.401978849268963 2983 3976905 SGTC_135 0933-0004 26.348 µM -0.249445064252938 0.412699500158682 no 1998 0.401508265151497 2967 21230617 YGL099W LSG1 SGTC_729 4092-0585 94.1 µM -0.250710488182959 0.412169877793013 no 1999 0.401018975609468 2822 2169061 SGTC_249 wiskostatin 11.211 µM -0.250963850870177 0.412063856192948 no 2000 0.400921028872561 2861 2775510 A n-wasp and actin depolymerizer. SGTC_1733 st037357 54.9 µM -0.253595460209784 0.410963019574195 no 2001 0.39990405211839 2806 1272339 YGL099W LSG1 SGTC_747 3448-8087 38.7 µM -0.253897947218306 0.410836530046393 no 2002 0.399787200361311 2913 5168703 SGTC_1310 1188-0297 994 nM -0.254931356545634 0.410404464291242 no 2003 0.399388058594406 2900 1588352 SGTC_1223 0764-0573 147 µM -0.255567540468763 0.410138531478507 no 2004 0.399142392562573 2850 1609797 SGTC_2165 5727197 32.143 µM -0.256371390376139 0.409802571298364 no 2005 0.398832038486241 3255 1361712 SGTC_523 1934-0222 13.7 µM -0.256622620680611 0.409697585939019 no 2006 0.398735055440838 2863 1361595 SGTC_1792 st045773 43.6 µM -0.258191368110827 0.409042176740556 no 2007 0.398129609695783 2846 2919270 SGTC_876 0720-0963 56.8 µM -0.258571355879524 0.408883459292693 no 2008 0.397982993235758 3058 765861 SGTC_265 mycophenolic acid 32.932 µM -0.258700158725132 0.408829662900236 no 2009 0.397933298542827 3100 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_533 1222-0222 6.71 µM -0.258997394637946 0.40870552453022 no 2010 0.397818625352267 3059 3982874 SGTC_77 0828-0286 12.516 µM -0.259215318357989 0.408614516126267 no 2011 0.397734556300461 2819 745345 SGTC_86 0417-1630 471.922 µM -0.259282990711125 0.408586256080113 no 2012 0.397708451110911 2903 3634867 SGTC_3307 9126885 69.2785 µM -0.260189878868196 0.408207584551195 no 2013 0.39735865548473 2860 24824909 SGTC_1470 k295-0292 231 µM -0.260215667133945 0.408196817901643 no 2014 0.39734870990407 2969 5045612 SGTC_1831 st055328 12 µM -0.261566764999064 0.407632829123769 no 2015 0.396827734903548 3030 1103068 SGTC_1856 st057054 55.7 µM -0.264079558042841 0.406584423719235 no 2016 0.395859307623718 3122 1266018 SGTC_783 0848-0141 92.7 µM -0.264615975671983 0.40636070216475 no 2017 0.395652655958051 2845 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_153 4077-0274 519.67 µM -0.26595754364654 0.405801313744009 no 2018 0.395135953494159 3192 3121976 SGTC_3337 9144342 33.5465 µM -0.266167357446677 0.405713845852981 no 2019 0.395055160736976 2959 17682949 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.266995698491144 0.405368570236624 no 2020 0.394736236509309 2862 15053 SGTC_1254 0550-0035 264 µM -0.269101665764858 0.404491076575798 no 2021 0.39392572430379 3014 15121435 SGTC_2385 9074692 200 µM -0.270139153298453 0.404058962781911 no 2022 0.393526600729553 2910 17046906 SGTC_1562 morin hydrate 59.1 µM -0.270801370688268 0.40378321024927 no 2023 0.393271902799746 3062 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_455 paf C-16 10 µM -0.270989853906437 0.403704733089386 no 2024 0.39319941790269 2875 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2022 5136654 200 µM -0.274215931971734 0.402362121830487 no 2025 0.39195934263819 3041 1713771 SGTC_2321 7390090 138.78 µM -0.274467505138675 0.402257471680883 no 2026 0.391862686120001 2964 649046 SGTC_645 0845-0943 5.41 µM -0.275284832796494 0.40191752569428 no 2027 0.391548708078683 2941 1885106 SGTC_2557 derrustone 83.84 µM -0.275550635575341 0.401806987979793 no 2028 0.391446614625571 3019 629853 An antioxidant. SGTC_2724 maprotiline 69.64 µM -0.275554251903372 0.40180548413455 no 2029 0.391445225664486 2969 4011 A tricyclic antidepressant. SGTC_3006 9075424 71.4286 µM -0.278241954970975 0.400688209922131 no 2030 0.390413315245816 2930 7465181 SGTC_1850 st056238 17 µM -0.278553708462012 0.400558666835053 no 2031 0.390293671137829 2858 5393177 SGTC_877 0771-0151 33.1 µM -0.279354896888127 0.400225798802752 no 2032 0.389986240390901 2994 6166523 SGTC_1581 himbacine 57.9 µM -0.279384487893561 0.400213506077568 no 2033 0.389974887093758 2891 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1240 0356-0016 42.1 µM -0.279617945213943 0.400116526470845 no 2034 0.389885318899875 2935 4305613 SGTC_3091 9116372 49.47 µM -0.281898322134059 0.399169568661707 no 2035 0.389010738064304 3059 17169793 SGTC_3266 9136860 49.47 µM -0.282101211039076 0.399085344907704 no 2036 0.388932952326602 2987 4871271 YPR165W RHO1 SGTC_744 1594-0068 283 µM -0.282461880136503 0.398935634642887 no 2037 0.388794686109443 2934 668392 SGTC_1392 3455-1037 33.9 µM -0.282507660570027 0.398916632689178 no 2038 0.388777136715289 3057 981132 SGTC_3281 9140613 49.47 µM -0.283269959657225 0.398600262624571 no 2039 0.388484951650032 2946 16013766 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.283694642696067 0.398424039164839 no 2040 0.388322200320199 2843 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3041 9091929 49.47 µM -0.283914416509002 0.398332851513519 no 2041 0.388237984073705 3087 25236887 SGTC_1722 st034304 3.6505 µM -0.284087786498979 0.398260921463309 no 2042 0.388171553251806 2911 4036148 YLR033W RSC58 SGTC_1526 st051518 75 µM -0.284516855137134 0.398082918622498 no 2043 0.388007159503138 2953 673993 SGTC_873 0591-4978 488 µM -0.285530124550199 0.397662639279012 no 2044 0.387619014240757 3113 3305145 SGTC_2007 4011539 71.82 µM -0.286493397313898 0.397263207418549 no 2045 0.387250124909778 2891 45595301 SGTC_1829 berberine 14.4 µM -0.286673755833777 0.397188431694919 no 2046 0.387181067164727 3088 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_524 r073-0010 27.8 µM -0.287126911937397 0.397000572163539 no 2047 0.387007573302269 2899 2772106 SGTC_1449 4112-4002 201 µM -0.288097770250637 0.396598175486387 no 2048 0.386635949692394 2942 2059539 SGTC_1738 st035555 74 µM -0.288726962589071 0.396337449647414 no 2049 0.386395163926596 3026 5331140 SGTC_3349 9149703 23.001 µM -0.288833476009649 0.396293317011504 no 2050 0.386354406606783 2876 4910494 SGTC_12 0849-0099 9.267 µM -0.290597371725881 0.395562660322165 no 2051 0.385679635217029 2972 6071388 SGTC_120 rhodamine 6G 52.259 µM -0.290901991283761 0.39543651516209 no 2052 0.385563139160673 2890 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_837 0091-0265 12.5 µM -0.292740872952165 0.394675254088845 no 2053 0.384860112833617 2922 759367 SGTC_1011 4112-3381 17.4 µM -0.293409376771551 0.394398606053642 no 2054 0.384604629533671 3082 2877139 SGTC_2099 5377090 177.372 µM -0.293432737441835 0.394388939631291 no 2055 0.384595702650013 3006 2243829 SGTC_1049 3226-0134 66 µM -0.293948193171303 0.394175665531592 no 2056 0.384398745570812 2964 5702385 SGTC_3083 9117465 49.47 µM -0.294616525698806 0.393899184628619 no 2057 0.384143418273353 3031 16420915 SGTC_676 falcarinol 140 µM -0.295207030744997 0.393654944479372 no 2058 0.38391786572633 3118 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1655 st012546 55.1 µM -0.295228960796697 0.393645874745345 no 2059 0.383909489960179 3033 720985 YLR208W SEC13 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.295989783344072 0.393331252870548 no 2060 0.38361894185949 2933 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1116 jasmonic acid  1.58368 µM -0.296676856898951 0.393047188151752 no 2061 0.383356613740224 3085 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3232 9132874 49.47 µM -0.296945912073303 0.392935965084403 no 2062 0.383253901691183 2928 3784940 SGTC_3127 9126946 49.47 µM -0.297021366525587 0.392904775000325 no 2063 0.383225098360799 3012 27243249 SGTC_2610 ononetin 44.17 µM -0.298523312182831 0.392284069443382 no 2064 0.382651893113963 2987 259632 SGTC_1321 1326-2144 215 µM -0.299264577903226 0.391977829166988 no 2065 0.382369089755758 3053 3513030 SGTC_1709 st033179 39.1045 µM -0.300334851604955 0.391535783389647 no 2066 0.381960875905602 2932 573381 SGTC_1236 0330-0013 258 µM -0.301159655213995 0.391195217477542 no 2067 0.38164637646604 2976 4617066 SGTC_1609 st001574 46.4 µM -0.301258864717942 0.391154258946297 no 2068 0.381608552921774 2924 3960012 SGTC_2106 5357045 167.29 µM -0.302745943191791 0.390540465176206 no 2069 0.381041741093907 3024 668842 SGTC_1038 k292-0204 154 µM -0.302789290476633 0.390522577605006 no 2070 0.381025222751579 2897 4454212 SGTC_459 nigericin 15.3 µM -0.304453157744303 0.389836146201406 no 2071 0.380391337282875 3071 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_69 0096-0274 206.684 µM -0.304730630875096 0.389721707522857 no 2072 0.380285659206745 3224 6741392 SGTC_2988 9073640 71.4286 µM -0.308565631772887 0.388141015349706 no 2073 0.378825983865009 3162 9102229 SGTC_1249 0481-0015 10.2 µM -0.308744883489177 0.388067177328531 no 2074 0.378757799281855 2911 4227577 SGTC_596 1155-0152 116 µM -0.309059542372264 0.387937571680115 no 2075 0.378638117031673 2975 280313 SGTC_2835 9006588 71.43 µM -0.309206766243623 0.387876935550397 no 2076 0.37858212361216 3174 2345538 SGTC_486 niguldipine 82 µM -0.309311611880202 0.387833755132768 no 2077 0.378542249392789 2949 1236 A calcium channel blocker. SGTC_1333 1482-0047 286 µM -0.309784010592051 0.387639216095759 no 2078 0.378362605792059 3088 3811116 SGTC_2418 pentamidine 31.67 µM -0.309934446093615 0.387577271003814 no 2079 0.378305403754091 3033 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_13 0199-0087 65 µM -0.310021489509181 0.387541430289809 no 2080 0.378272307327456 2941 4589825 SGTC_654 1124-0271 80.9 µM -0.310267295759571 0.387440223082068 no 2081 0.378178849497509 2965 5403748 SGTC_2299 7976368 114.88 µM -0.310478585554107 0.387353233644342 no 2082 0.37809852084232 3100 2979718 SGTC_1798 st045719 60.953 µM -0.312464572425377 0.386535866395375 no 2083 0.377343741624252 2996 3980186 SGTC_2354 9060492 162 µM -0.313877390151238 0.385954702872946 no 2084 0.376807081629866 3112 6471895 SGTC_1569 carminic acid 40.6 µM -0.314588379021398 0.385662333814129 no 2085 0.376537101848914 3131 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2258 7960471 200 µM -0.316877501046146 0.384721455198311 no 2086 0.375668277257999 3034 2974708 SGTC_2055 5235184 200 µM -0.317349435252112 0.38452756422543 no 2087 0.375489235231295 3128 2836034 SGTC_2413 inermin 26.06 µM -0.317965971662977 0.384274307935443 no 2088 0.375255374534384 3245 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2466 5983409 37.09 µM -0.318064290530569 0.384233925798435 no 2089 0.375218085078514 2988 2879657 SGTC_847 0342-0274 5.54 µM -0.318875720673904 0.38390069817835 no 2090 0.374910378035966 3093 18097 SGTC_1112 tnp00069 1.16933 µM -0.319326063626675 0.383715794185185 no 2091 0.374739635261809 3061 145826 SGTC_33 0986-0033 35.816 µM -0.319519529637037 0.383636368099721 no 2092 0.374666292204843 2988 2848082 SGTC_3103 9120822 49.47 µM -0.321349847903765 0.382885186395044 no 2093 0.373972642355303 3191 17141819 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.321416633204749 0.382857785319745 no 2094 0.373947339914028 2967 16623 A steroid. SGTC_695 3505-6186 243 µM -0.322344301379736 0.382477236722323 no 2095 0.373595937510418 3085 1819379 SGTC_2200 6600604 21.907 µM -0.322748620633929 0.382311412115405 no 2096 0.37344281349521 2961 2904777 SGTC_1156 4092-0367 4.88 µM -0.32380314030033 0.381879020578578 no 2097 0.373043539283763 3012 1357585 SGTC_1597 7-benzyloxygramine 47.5 µM -0.325016363338648 0.381381737131458 no 2098 0.372584343651321 2978 260807 SGTC_2083 5306046 65.942 µM -0.325255385281571 0.38128378838037 no 2099 0.372493897003014 2984 539837 SGTC_2369 9071472 200 µM -0.325339170098085 0.381249456017826 no 2100 0.372462194231359 3113 17296037 SGTC_1956 st077085 54 µM -0.327464661841596 0.38037881012859 no 2101 0.371658233314974 3002 24208685 SGTC_302 1094-0063 18.9 µM -0.328547436574118 0.37993551550972 no 2102 0.371248891859913 2963 5440289 SGTC_710 3448-4187 58 µM -0.32873913920894 0.379857047691074 no 2103 0.371176434108377 3026 3946412 SGTC_2854 9024559 71.43 µM -0.329290290947579 0.379631477548251 no 2104 0.370968140997819 3069 3163529 SGTC_907 3448-6986 75.5 µM -0.329335573347829 0.379612946617805 no 2105 0.370951029401095 3167 590582 SGTC_2394 5221648 200 µM -0.33189466100593 0.378566140960615 no 2106 0.369984401004981 3118 788586 SGTC_1845 st056753 3.01 µM -0.333781148022702 0.377795035090907 no 2107 0.369272355047181 2933 5375839 SGTC_1591 genipin 88.4 µM -0.334254442184507 0.377601651276201 no 2108 0.369093782558733 3115 442424 A DNA cross-linking agent. SGTC_1097 itavastatin 7.23 µM -0.335129589664441 0.377244154585053 no 2109 0.368763666433783 3032 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_100 0086-0128 49.5915 µM -0.336448943708792 0.376705398937028 no 2110 0.3682661733164 3042 93297 SGTC_3185 9108267 49.47 µM -0.337190697793379 0.376402610444088 no 2111 0.367986574600843 3070 4910486 SGTC_90 0870-0863 4.608 µM -0.337407822502077 0.376313993206588 no 2112 0.367904744271231 2954 1738164 SGTC_672 1441-0018 53.7 µM -0.337437753452295 0.376301777705446 no 2113 0.367893464313856 2982 251141 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.338543198829307 0.375850707208244 no 2114 0.367476939419752 3187 23847180 SGTC_2296 7971656 126.45 µM -0.339018077998605 0.375656987589973 no 2115 0.367298055752803 3067 666570 SGTC_2460 5552655 174.22 µM -0.339929734866735 0.375285179134703 no 2116 0.366954721713844 3131 5401989 SGTC_554 4483-2211 187 µM -0.340096391249973 0.375217222815649 no 2117 0.366891969671078 3091 747107 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.341775785505755 0.374532644322261 no 2118 0.36625981689445 3019 688669 SGTC_2913 7966556 36.57 µM -0.342396265645613 0.37427981530002 no 2119 0.366026349220629 3148 2976516 SGTC_707 0865-0008 204 µM -0.343004400779531 0.37403206898943 no 2120 0.365797574718625 3009 723043 SGTC_2228 7354201 200 µM -0.343879970440161 0.373675464737083 no 2121 0.365468277782071 3039 753451 SGTC_1952 st077036 64.1 µM -0.344245368216781 0.373526676554597 no 2122 0.365330882992039 2977 2937007 SGTC_3113 9123498 49.47 µM -0.346266574012719 0.372703992559032 no 2123 0.364571193326511 3069 8897275 SGTC_2846 9008642 19.48 µM -0.346417453310833 0.372642603942274 no 2124 0.364514505174045 3128 2992898 SGTC_585 0kpi-0023 191 µM -0.346778653152499 0.372495654853197 no 2125 0.364378807728831 3148 64601 SGTC_2703 st077852 53.4 µM -0.347411495880909 0.372238236421882 no 2126 0.36414109904803 3137 6281836 SGTC_420 mitomycin C 81.9 mM -0.348495868566545 0.371797284046097 no 2127 0.363733908004353 3013 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3063 1327-0034 4 µM -0.349050886096559 0.371571655160066 no 2128 0.363525553761857 3107 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1608 st001473 40.5 µM -0.349497430278083 0.371390155498077 no 2129 0.363357949840161 3027 7292267 SGTC_1713 st033146 12.748 µM -0.350745069302359 0.370883199312506 no 2130 0.362889805237222 3178 674619 SGTC_297 0986-0032 24 µM -0.350987563952027 0.370784691851319 no 2131 0.3627988390812 2980 2847425 SGTC_1547 harmine 94.2 µM -0.351187158738047 0.370703617753778 no 2132 0.362723971607059 3050 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1694 st024011 44.9 µM -0.353408167768426 0.369801846520671 no 2133 0.361891231701826 3124 2787533 SGTC_1357 1503-1303 39.5 µM -0.353584163652317 0.369730419429516 no 2134 0.36182527211037 3049 292895 SGTC_3038 9091290 49.47 µM -0.354034802311656 0.369547550369222 no 2135 0.36165640084119 3191 25236843 SGTC_792 4534-1957 155 µM -0.355513644686905 0.36894764397865 no 2136 0.361102412360184 3040 1717904 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.356452000225811 0.368567156571821 no 2137 0.360751046342226 3107 688801 SGTC_2016 5121758 140 µM -0.356736444393151 0.368451844667478 no 2138 0.36064455978754 3001 2795203 SGTC_1629 st005085 44.9 µM -0.357580257076336 0.368109837964145 no 2139 0.360328727629267 3007 24207091 SGTC_867 0518-0118 155 µM -0.357586617678524 0.368107260337567 no 2140 0.360326347269674 3136 6848158 SGTC_949 1165-0505 146 µM -0.357952043675358 0.367959181854368 no 2141 0.36018960118596 3038 6244267 SGTC_3311 9131146 2.8755 µM -0.358263264058436 0.367833084122219 no 2142 0.360073153490535 3070 4900406 YPR165W RHO1 SGTC_2701 st077767 14.721 µM -0.358653274329479 0.367675083056748 no 2143 0.359927243727288 3070 5721188 SGTC_726 3448-4391 34.2 µM -0.358683016567943 0.367663034791754 no 2144 0.359916117465358 3210 1356692 SGTC_2816 7982706 58.44 µM -0.358884723105463 0.367581329052295 no 2145 0.359840664280999 3131 2981853 SGTC_2149 5554786 194.827 µM -0.359828276077339 0.367199201487867 no 2146 0.359487778162345 3048 745063 YPR165W RHO1 SGTC_584 0986-0246 15.4 µM -0.36170670141571 0.366438853710231 no 2147 0.358785609336814 3131 53315 YDR232W HEM1 SGTC_1854 st056233 32.9 µM -0.361778050135559 0.366409983532434 no 2148 0.358758948062954 3143 5393174 SGTC_782 0083-0095 30.5 µM -0.365325706651722 0.364975434513659 no 2149 0.357434145715255 2999 3591729 An indicator and reagent. SGTC_861 0443-0273 110 µM -0.365537068400408 0.364890026561238 no 2150 0.357355270856515 3140 6149169 SGTC_1975 st070967 30.8 µM -0.367025182426809 0.364288893098072 no 2151 0.356800116997604 3216 261391 SGTC_2810 7959871 45.46 µM -0.367231247825974 0.364205677891995 no 2152 0.356723266381096 3148 2974535 SGTC_497 capsazepine 133 µM -0.368074276747734 0.363865304977964 no 2153 0.356408925366631 3065 2733484 A calcium channel blocker. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.368635940418564 0.363638592869947 no 2154 0.356199551407198 3136 368090 SGTC_3316 9136639 10.545 µM -0.369653133972815 0.363228130475329 no 2155 0.355820477845038 3156 4903665 SGTC_6 0844-0013 19.835 µM -0.369695130979811 0.363211187031332 no 2156 0.355804830044939 3150 1584900 SGTC_1308 1187-1617 41.4 µM -0.369883470241552 0.363135205962746 no 2157 0.355734659100929 3034 2882570 SGTC_1417 3966-0327 90.4 µM -0.370240060672968 0.362991362650981 no 2158 0.355601814971821 3108 651118 SGTC_3109 9122853 49.47 µM -0.370436672732773 0.362912060515034 no 2159 0.355528576653367 3095 1234709 SGTC_3020 9089140 49.47 µM -0.370675784046539 0.362815624516174 no 2160 0.355439514480533 3154 17217859 SGTC_1161 k007-0610 110 µM -0.372652465262941 0.362018742840387 no 2161 0.354703559624642 3183 5843850 SGTC_1950 st077106 7.18 µM -0.37296030006739 0.361894695650526 no 2162 0.354588995758108 3137 13831864 SGTC_2222 6885208 172.143 µM -0.373005085137209 0.361876649965181 no 2163 0.354572329632659 3095 609514 SGTC_2404 5161160 200 µM -0.373658518525627 0.361613390618701 no 2164 0.354329195389515 3005 2831543 SGTC_2813 7971799 71.43 µM -0.373736520272704 0.361581969158243 no 2165 0.354300175896607 3150 2234054 SGTC_1384 3089-0840 101 µM -0.374213841769072 0.3613897099772 no 2166 0.35412261333598 3182 1069836 SGTC_2753 fluvastatin 17.09 µM -0.3744235068925 0.361305270524723 no 2167 0.35404462838766 3131 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1153 4055-0057 267 µM -0.374494432689275 0.361276707763577 no 2168 0.354018248921217 3061 882706 SGTC_2700 st077718 96.8 µM -0.375447880255582 0.360892816881501 no 2169 0.35366370076375 3108 904970 SGTC_1070 indatraline 8.81 µM -0.376489116554745 0.36047373927551 no 2170 0.353276652534969 3079 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_349 k015-0014 24 µM -0.376974677913724 0.360278367410284 no 2171 0.353096211570074 3006 2196908 SGTC_194 1486-1323 56.904 µM -0.378019369422749 0.359858146066835 no 2172 0.352708102526412 3111 5178754 SGTC_2662 daunorubicin 22.37 µM -0.378153984957568 0.35980401002298 no 2173 0.352658103200496 3087 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2943 9068529 45.32 µM -0.378501456284121 0.359664286381421 no 2174 0.352529056071528 3073 3270634 SGTC_2140 5586273 200 µM -0.380122729914444 0.3590125951568 no 2175 0.351927156954281 3136 854421 SGTC_1493 4348-0038 111 µM -0.382020861247285 0.358250138706447 no 2176 0.351222945512895 3163 800424 SGTC_1023 4482-3888 16 µM -0.382842896743255 0.357920112077784 no 2177 0.350918126576766 3245 3303168 SGTC_1480 1070-0044 41.2 µM -0.38310592937031 0.357814533484796 no 2178 0.350820611710049 3153 3124987 SGTC_1204 4049-0315 18.3 µM -0.384002893343712 0.357454583192873 no 2179 0.35048815151367 3291 588402 SGTC_1958 st076513 41.9 µM -0.384950941603445 0.357074270662944 no 2180 0.35013688136116 3055 732122 YGL099W LSG1 SGTC_2342 7990637 118.86 µM -0.385197581411506 0.356975353587268 no 2181 0.350045517557705 3182 2033102 YER133W GLC7 SGTC_36 0335-0881 14.2 µM -0.391372349097763 0.354502057392877 no 2182 0.347761013928411 3137 23828853 SGTC_3187 9109394 49.47 µM -0.391650751491203 0.354390687112287 no 2183 0.347658141635674 3125 17098090 SGTC_1649 st011737 51.3 µM -0.392712238509308 0.353966171056707 no 2184 0.34726601520467 3145 1761035 SGTC_2556 citropten 84.59 µM -0.392744935165867 0.353953097698197 no 2185 0.34725393924802 3117 2775 A potential DNA crosslinker. SGTC_2155 5570423 76 µM -0.393819444332333 0.35352356422828 no 2186 0.34685717382474 3092 797402 SGTC_2649 anisomycin 9.56 µM -0.395423332630269 0.352882759231155 no 2187 0.346265246122704 3162 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2391 6285546 200 µM -0.396364216717788 0.35250703973575 no 2188 0.34591817995487 3066 846083 SGTC_2657 nystatin 74.44 µM -0.397934646230158 0.351880246959022 no 2189 0.345339180242693 3158 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_362 0310-0100 9.03 µM -0.398027482339149 0.35184320661503 no 2190 0.345304963924434 3225 790235 SGTC_636 0kpi-0074 126 µM -0.399315366683213 0.351329503486251 no 2191 0.344830422904077 3158 616434 SGTC_1672 st016598 6.51 µM -0.399696775120824 0.35117742177155 no 2192 0.34468993382918 3117 4665860 YNL267W PIK1 SGTC_772 k072-0172 35.3 µM -0.400319966964985 0.350928983315936 no 2193 0.344460431652893 3107 5861980 SGTC_2162 5663267 200 µM -0.402272268693511 0.350151101625771 no 2194 0.343741830574378 3243 6456493 SGTC_1231 0242-0792 125 µM -0.402321032576353 0.350131680009046 no 2195 0.343723888829706 3099 3707635 SGTC_974 1326-0144 138 µM -0.403551962326302 0.349641556835879 no 2196 0.343271108284463 3133 5411856 SGTC_922 1866-0035 480 µM -0.403942429426611 0.349486135619048 no 2197 0.343127527292781 3104 3156169 SGTC_2864 9034755 47.6 µM -0.404137763912727 0.349408394300021 no 2198 0.343055708177646 3208 4930451 SGTC_1933 st074711 15.9 µM -0.404551369118129 0.349243804104564 no 2199 0.342903655639731 3153 17250958 SGTC_1659 st012954 42.1 µM -0.405029536535516 0.349053557333419 no 2200 0.342727899982328 3219 24207262 SGTC_469 w7 172 µM -0.405898014853253 0.348708115992687 no 2201 0.342408768360908 3179 45115570 A P450 inhibitor. SGTC_3066 9117245 49.47 µM -0.406095319462329 0.348629654624595 no 2202 0.342336282349868 3134 17176980 SGTC_1311 1190-0148 100 µM -0.40706941244632 0.348242385743026 no 2203 0.341978504025535 3252 1961333 SGTC_2713 st079149 53.4 µM -0.407279152360522 0.348159020400413 no 2204 0.341901486401712 3187 3103253 SGTC_1182 1222-0449 220 µM -0.407283497263534 0.348157293508974 no 2205 0.341899890999517 3185 658318 SGTC_2907 7721985 69.9 µM -0.409046040783663 0.347457026682519 no 2206 0.341252936901415 3184 3267881 SGTC_894 0960-0238 55.9 µM -0.40944614579556 0.347298135455608 no 2207 0.341106140394476 3246 6741907 YDL195W SEC31 SGTC_125 0133-0007 11.75 µM -0.409991836031052 0.347081472129611 no 2208 0.340905968171437 3271 26541 SGTC_1365 1672-3266 55.4 µM -0.412426367492144 0.346115464442213 no 2209 0.340013470060128 3225 6415873 SGTC_2900 5328528 85.29 µM -0.413480944681294 0.345697324624594 no 2210 0.339627140315949 3136 795359 SGTC_1458 k015-0034 6.33 µM -0.413894097648859 0.3455335607579 no 2211 0.339475833346393 3173 3598957 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.41688651985829 0.344348301353677 no 2212 0.338380706972345 3164 165521 SGTC_464 bw-b 70c 158 µM -0.41829494068969 0.34379097197727 no 2213 0.33786574411956 3244 5353454 SGTC_728 3030-5151 22.5 µM -0.418679012547525 0.343639048866158 no 2214 0.337725367991119 3134 3125388 SGTC_2852 9023854 51.95 µM -0.419521811402237 0.343305760655975 no 2215 0.337417408827737 3291 19798528 SGTC_2889 9059656 51.95 µM -0.419986301040063 0.343122128408274 no 2216 0.337247730581363 3220 3949838 SGTC_2236 dapsone 200 µM -0.421073706987214 0.342692376125527 no 2217 0.336850630255817 3216 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3147 9097027 49.47 µM -0.422797208042697 0.342011650587531 no 2218 0.336221612428716 3148 25236841 SGTC_3249 9135183 49.47 µM -0.422882914979288 0.341977812578404 no 2219 0.336190344329907 3285 4902779 SGTC_731 3966-0296 387 µM -0.42307339132737 0.341902615037669 no 2220 0.336120857708497 3132 660956 SGTC_2553 4-methylesculetin 85.09 µM -0.423345217194248 0.341795312645544 no 2221 0.336021704117449 3210 5319502 SGTC_2271 7849410 118.62 µM -0.424177040892749 0.341467032324305 no 2222 0.335718351703066 3291 972430 SGTC_1374 2889-5571 141 µM -0.424334512096168 0.341404899596234 no 2223 0.335660936588414 3188 2853281 SGTC_3026 9090633 49.47 µM -0.424534424069741 0.341326027390228 no 2224 0.335588052795556 3137 25236842 SGTC_643 k048-0106 28.4 µM -0.424606543862188 0.341297575332099 no 2225 0.335561760921002 3244 6763920 SGTC_305 1682-2595 20.8 µM -0.424785666786645 0.34122691325442 no 2226 0.33549646364151 3212 226033 SGTC_480 am 92016 50 µM -0.426024064539023 0.340738530997983 no 2227 0.335045155452302 3213 2129 K+ channel blocker. SGTC_2037 5169046 200 µM -0.426811041357584 0.340428312522562 no 2228 0.334758481855986 3256 5718022 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.428676673357166 0.339693330410338 no 2229 0.334079269319198 3079 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1511 0906-3109 28.5 µM -0.430174737974253 0.339103595446885 no 2230 0.333534268405644 3195 2882180 SGTC_2105 5350118 200 µM -0.430651583537101 0.338915960840953 no 2231 0.333360864014909 3193 2133313 SGTC_898 1000-0849 28.3 µM -0.431910105754395 0.338420935228834 no 2232 0.332903374805793 3246 6751807 SGTC_874 0599-0792 117 µM -0.432611377640765 0.338145218821058 no 2233 0.332648561168816 3314 765305 SGTC_580 1123-0028 41 µM -0.432873762512363 0.338042080258354 no 2234 0.332553241059418 3183 1677248 YPR107C YTH1 SGTC_2521 angolensin 13.4 µM -0.433173981904739 0.337924084567742 no 2235 0.332444189570935 3289 821428 A flavenoid. SGTC_2719 novobiocin 32.65 µM -0.434095264693697 0.337562090825554 no 2236 0.332109631998554 3284 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1482 3346-2049 8.48 µM -0.434457220738017 0.33741991085062 no 2237 0.331978226715018 3255 3826804 SGTC_2855 9016525 58.44 µM -0.435369150888136 0.337061798453637 no 2238 0.331647249314568 3163 43811474 SGTC_2336 9001819 198.65 µM -0.436160578460813 0.336751126706935 no 2239 0.331360113792758 3376 2989602 SGTC_1154 4088-0362 150 µM -0.438433119127214 0.335859669517709 no 2240 0.330536171292138 3172 6618304 SGTC_2434 5670830 169.91 µM -0.439011322262361 0.335633002874556 no 2241 0.330326666185609 3242 1549830 SGTC_698 k064-0052 127 µM -0.439025235742903 0.335627549261579 no 2242 0.330321625454487 3286 5088751 SGTC_520 3584-0023 682 µM -0.44193213742062 0.334488903099086 no 2243 0.329269157073017 3204 1340790 SGTC_2511 berberine 10.47 µM -0.442392230450741 0.334308821773128 no 2244 0.329102700164257 3177 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1302 1159-0335 255 µM -0.444513476991525 0.333479055314029 no 2245 0.328335693657096 3179 649284 SGTC_1349 flufenamic acid 69 µM -0.445128939752407 0.333238457376369 no 2246 0.328113288012597 3170 3371 A non-steroidal anti-inflammatory. SGTC_793 0488-0545 106 µM -0.445590742991845 0.333057973372753 no 2247 0.327946449279259 3165 292548 SGTC_1316 1272-0050 65.9 µM -0.446164498162734 0.332833789674499 no 2248 0.327739212748143 3231 7340392 SGTC_1559 coumarin 343 70.1 µM -0.446950142067391 0.332526911496817 no 2249 0.32745552947841 3328 108770 A hepatotoxic, DNA x-linker. SGTC_2193 5925765 200 µM -0.447160376562463 0.33244481140836 no 2250 0.327379634098347 3267 877370 SGTC_1105 epirubicin 18.1 µM -0.448581699752336 0.331889971951094 no 2251 0.326866718807404 3166 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2815 7968870 71.43 µM -0.448818404793417 0.331797605576737 no 2252 0.326781330394602 3193 2977326 YHR190W ERG9 SGTC_835 0312-0010 67.2 µM -0.449080887475254 0.331695192278257 no 2253 0.326686653623763 3160 1626196 SGTC_353 1988-1175 58.3 µM -0.449246172844706 0.331630709068031 no 2254 0.326627041377968 3088 2788357 SGTC_1462 k081-0014 26.5 µM -0.449346188813978 0.33159169200109 no 2255 0.326590971511122 3175 3270634 SGTC_1734 st037168 69.4 µM -0.449503942714559 0.331530154597732 no 2256 0.326534082269472 3262 708907 SGTC_2445 5742597 35.57 µM -0.449931001294893 0.331363588345025 no 2257 0.326380096567661 3154 1774255 SGTC_929 2805-0021 398 µM -0.450589767866655 0.331106714116413 no 2258 0.326142621295383 3270 3098024 SGTC_1833 st055984 71 µM -0.451046330324445 0.330928732376969 no 2259 0.325978078858374 3205 676288 SGTC_2686 alizarin 95.37 µM -0.45156123598294 0.330728052549062 no 2260 0.325792550526632 3212 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2643 anethole 100 µM -0.45269525508509 0.330286250453373 no 2261 0.325384098373993 3264 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_812 4251-0442 148 µM -0.452763306519208 0.330259745835123 no 2262 0.325359594202474 3301 5723007 SGTC_2043 5101342 149 µM -0.453241252087699 0.330073619978412 no 2263 0.325187515356387 3214 678451 SGTC_1527 coumarin 137 µM -0.453378836789803 0.330020048300542 no 2264 0.325137986462671 3339 323 A hepatotoxic, DNA x-linker. SGTC_191 3914-0123 66.505 µM -0.455175988102392 0.329320607736853 no 2265 0.324491316886643 3157 3144412 SGTC_2512 diallyl trisulfide 49.23 µM -0.457752655453669 0.328318825924988 no 2266 0.323565076749975 3292 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2905 7799065 20.05 µM -0.458653246215937 0.327968975948408 no 2267 0.323241596707826 3337 1296806 SGTC_1238 0333-0287 48.8 µM -0.458725177952862 0.327941039331096 no 2268 0.32321576555749 3232 7226 SGTC_2971 9092186 9.93 µM -0.45975396950888 0.327541585978522 no 2269 0.322846413200724 3158 25236400 SGTC_126 0417-1624 672.48 µM -0.46056467442388 0.327226949060343 no 2270 0.322555480410505 3363 41912 YDL195W SEC31 SGTC_3182 9108849 49.47 µM -0.460927215068199 0.327086285688645 no 2271 0.322425412768279 3311 17133045 SGTC_1325 1431-0015 227 µM -0.461870494280425 0.32672041471321 no 2272 0.322087097125465 3198 1103340 SGTC_2597 laccaic acid a 100 µM -0.461917970319261 0.326702004518101 no 2273 0.322070073306755 3299 5491415 A textile dye. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.462259931741084 0.326569411640964 no 2274 0.321947464814064 3180 279621 SGTC_53 0973-0023 39.979 µM -0.465168850783464 0.325442388121954 no 2275 0.32090527173708 3381 674768 SGTC_796 1234-0020 70.7 µM -0.46543527264262 0.325339245919906 no 2276 0.32080988977829 3270 46495034 SGTC_499 genistein 192 µM -0.471243637850394 0.323093939600813 no 2277 0.318733379773008 3316 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2092 5303694 80.6725 µM -0.47250224983876 0.322608250099852 no 2278 0.318284168115549 3229 1963699 SGTC_438 sphingosine 6.67 µM -0.473470504851422 0.322234813142944 no 2279 0.317938769597452 3172 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1821 st053465 65.6 µM -0.474388365790884 0.321880977772411 no 2280 0.317611493947562 3276 675086 SGTC_2682 pyrogallin 40.03 µM -0.474437580975762 0.32186200987743 no 2281 0.317593949634705 3272 822798 An ATP competetive kinase inhibitor. SGTC_1113 artemisinin 1.17947 µM -0.475022502599931 0.321636612324984 no 2282 0.317385467154077 3322 2240 An anti-malaria and mitochondrial poison. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.476307420907911 0.321141703994495 no 2283 0.316927689654449 3352 7104 SGTC_2636 apigenin dimethyl ether 100 µM -0.477679078461311 0.32061373691813 no 2284 0.316439318681951 3368 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_521 r062-0005 13.8 µM -0.4776951638259 0.320607547622447 no 2285 0.316433593474409 3277 2832033 SGTC_358 0075-0058 9.45 µM -0.478446667398496 0.320318441146663 no 2286 0.316166162495145 3454 1069125 SGTC_3351 9150312 21.596 µM -0.478503855316125 0.320296445184376 no 2287 0.316145815467803 3325 4904905 SGTC_811 0416-0114 265 µM -0.479779608971795 0.31980592137375 no 2288 0.315692056839812 3350 6612453 SGTC_2826 7992541 19.48 µM -0.480351444509246 0.319586154339119 no 2289 0.315488757102314 3326 2985066 SGTC_1352 1496-0991 99 µM -0.481903986159079 0.318989803312126 no 2290 0.314937077144583 3239 3000039 SGTC_2721 ifenprodil 61.44 µM -0.483280939054097 0.318461289869812 no 2291 0.314448136083149 3373 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3258 9138477 49.47 µM -0.483432710465619 0.318403058283607 no 2292 0.314394263586935 3298 4970355 SGTC_263 alizarin 107.927 µM -0.484464017142181 0.318007485883971 no 2293 0.314028297628742 3288 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2112 5488546 200 µM -0.484605510144907 0.317953230403329 no 2294 0.313978102159789 3230 600757 SGTC_2133 5320837 200 µM -0.485593619736051 0.317574448832158 no 2295 0.313627660495986 3363 2841355 SGTC_2581 avocatin a 64 µM -0.485688230282287 0.317538190867973 no 2296 0.313594114857158 3246 6710728 A skin care supplement. SGTC_1682 st012968 530 nM -0.486551778308695 0.317207330962033 no 2297 0.313288001761254 3216 24207270 SGTC_1438 4092-1045 4 µM -0.487023340577832 0.317026718164354 no 2298 0.313120895224258 3257 1351342 SGTC_3291 9121177 71.43 µM -0.487896938820022 0.316692236982833 no 2299 0.312811421453465 3272 17015612 SGTC_3141 9094609 49.47 µM -0.488569930311045 0.316434665772215 no 2300 0.312573102910332 3173 25236309 YDL196W YDL196W SGTC_2725 haloperidol 53.21 µM -0.489200441604749 0.316193433586008 no 2301 0.312349898462201 3250 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1928 4'-methoxychalcone 40.3 µM -0.490454304747495 0.315713940906196 no 2302 0.311906228672912 3433 641818 SGTC_451 chloral hydrate 100 µM -0.492824439865007 0.31480841940686 no 2303 0.31106832018025 3349 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_294 k038-0071 157 µM -0.492910177948096 0.314775683575927 no 2304 0.311038027700819 3313 24152826 SGTC_2957 9076800 11.52 µM -0.493281840419401 0.314633795208499 no 2305 0.310906728888922 3269 16459615 SGTC_1084 voriconazole 435 nM -0.494207254564622 0.314280621819073 no 2306 0.310579908430728 3377 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1299 1079-1439 3.74 µM -0.495131838412926 0.31392793501433 no 2307 0.310253530436121 3284 323161 SGTC_1336 1486-0901 104 µM -0.495273326643367 0.313873978654186 no 2308 0.310203598280132 3336 5006114 SGTC_3120 9124077 49.47 µM -0.495344991500686 0.313846650868578 no 2309 0.310178308600886 3359 18774327 YGL155W CDC43 SGTC_616 4092-0450 108 µM -0.495959390601991 0.313612405470965 no 2310 0.309961531286252 3326 787165 SGTC_1555 citronellol 128 µM -0.497182060988226 0.313146474561828 no 2311 0.309530335277294 3340 8842 A terpine precursor. SGTC_2838 9002687 71.43 µM -0.497322907974986 0.313092820229263 no 2312 0.309480679956522 3234 6457060 SGTC_1959 st077091 55.8 µM -0.498140537604417 0.312781430122164 no 2313 0.309192495004016 3255 821356 YKL052C ASK1 SGTC_1192 1488-0095 21.4 µM -0.498975909759012 0.312463420788045 no 2314 0.308898177652109 3354 915875 SGTC_2246 7293507 91.5585 µM -0.499525427285992 0.312254306652202 no 2315 0.308704639141886 3364 887656 SGTC_2862 9027634 71.43 µM -0.500245069498621 0.31198054448624 no 2316 0.308451263539701 3221 5012562 SGTC_3102 9121669 49.47 µM -0.500769926198286 0.311780946972138 no 2317 0.308266526602361 3295 41905072 SGTC_2528 xanthyletin 44.79 µM -0.501494347077838 0.311505548087786 no 2318 0.308011627627393 3255 65188 An natural product with antifungal activity of unknown mechanism. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.501659638890513 0.311442724824557 no 2319 0.307953480051003 3412 1377 SGTC_1554 st069299 38.7 µM -0.501665146163424 0.31144063174305 no 2320 0.307951542744797 3344 24207999 SGTC_1463 k081-0032 34.1 µM -0.503302107509139 0.310818762341893 no 2321 0.307375942471436 3305 977755 SGTC_2233 sulbentine 40.3845 µM -0.503534485946046 0.310730527235504 no 2322 0.307294270268498 3340 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3296 9122258 64.045 µM -0.503602731120871 0.310704616312298 no 2323 0.307270286494269 3355 4730474 SGTC_1745 st081495 74 µM -0.503858657300889 0.310607456141146 no 2324 0.307180352302329 3369 13842402 YBL026W LSM2 SGTC_905 2-aminofluorene 215 µM -0.504932748595561 0.31019983073959 no 2325 0.306803035864061 3380 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2440 5628896 157.78 µM -0.506165280078936 0.309732363343281 no 2326 0.306370313224861 3285 5522048 SGTC_1513 0337-0559 19 µM -0.506980936414644 0.309423174991082 no 2327 0.306084097331419 3254 775073 SGTC_2628 lathosterol 100 µM -0.507157033859551 0.309356439965535 no 2328 0.30602231981452 3422 6710616 SGTC_3286 9117135 37.221 µM -0.508010722209622 0.309033009869432 no 2329 0.305722911888347 3262 3438150 SGTC_192 3455-0609 60.9 µM -0.508247478226252 0.308943338206399 no 2330 0.30563989915424 3414 3769639 SGTC_984 1492-0255 2.91 µM -0.509408164341249 0.308503891572855 no 2331 0.305233077400901 3352 1585198 SGTC_399 oxolinic acid 75 µM -0.509859871968898 0.308332944913596 no 2332 0.305074818362621 3288 4628 A DNA gyrase inhibitor. SGTC_1693 xanthone 101.9 µM -0.509933070404361 0.308305247216271 no 2333 0.305049176191431 3325 7020 An insecticide. SGTC_1670 st016595 4.04 µM -0.510392934147598 0.308131263455312 no 2334 0.304888103050861 3359 597879 SGTC_789 1309-1135 70.6 µM -0.511098506983403 0.307864402509815 no 2335 0.304641040669251 3385 3092424 SGTC_174 3553-0389 74.3 µM -0.512314682342941 0.307404660584926 no 2336 0.30421539558474 3410 738071 SGTC_2366 9070441 60.58 µM -0.512377217175408 0.307381029166366 no 2337 0.304193516393761 3291 6837235 SGTC_923 1900-2434 73.3 µM -0.51508492863752 0.306358574367587 no 2338 0.303246836975422 3360 5910570 SGTC_1730 st033808 45.1 µM -0.516405009440618 0.305860646194372 no 2339 0.302785783882621 3261 1045166 SGTC_3145 9085516 49.47 µM -0.516607306923427 0.305784372218772 no 2340 0.302715156956539 3360 25236195 SGTC_745 0469-0705 296 µM -0.516611185474122 0.305782909937438 no 2341 0.302713802933132 3515 3486736 SGTC_903 1134-0042 114 µM -0.516725991846436 0.305739627332956 no 2342 0.302673724625086 3320 701009 SGTC_107 0358-0022 2.6945 µM -0.518260634512392 0.305161319769408 no 2343 0.30213821729807 3370 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1757 st041620 31.8375 µM -0.52072281957691 0.304234497431336 no 2344 0.301279937692157 3370 5289815 SGTC_1671 st016596 74.5 µM -0.521129753129206 0.304081439217782 no 2345 0.30113819274812 3419 2829167 SGTC_422 cantharidin 155 µM -0.521152962828256 0.30407271048542 no 2346 0.301130109146137 3333 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2070 5230947 200 µM -0.521410092736376 0.303976016223795 no 2347 0.301040561066343 3436 2835538 SGTC_2675 theaflavin digallate 100 µM -0.522843103914161 0.303437380551196 no 2348 0.300541720499046 3393 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1588 farnesol 29.9 µM -0.522875367949034 0.303425258158188 no 2349 0.300530493475207 3375 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_23 0213-0011 39.996 µM -0.522934175196663 0.30340316338264 no 2350 0.300510030608306 3449 627608 SGTC_1662 st014054 52 µM -0.523014059365372 0.303373150839496 no 2351 0.300482234717494 3367 2838777 SGTC_3112 9123419 49.47 µM -0.523149986029945 0.303322086137331 no 2352 0.300434941373142 3418 17015854 SGTC_2142 5622915 118.518 µM -0.523504811718392 0.303188803922736 no 2353 0.300311501728383 3359 5322196 SGTC_1477 0139-0234 16 µM -0.52512667928662 0.302579919918146 no 2354 0.299747565333016 3385 620880 SGTC_3317 9138495 8.753 µM -0.525758443716191 0.302342890355554 no 2355 0.299528025629303 3407 17020139 SGTC_1887 st057648 70.8 µM -0.526699240936673 0.301990070286146 no 2356 0.299201231412757 3424 688672 SGTC_175 3793-3120 23.7 µM -0.526782129931735 0.301958993919328 no 2357 0.299172446945925 3306 5322297 SGTC_2261 9010538 184.68 µM -0.527709428716281 0.301611433235415 no 2358 0.298850514022314 3382 6457250 SGTC_1550 gossypolone 36.6 µM -0.529218246221297 0.301046298571307 no 2359 0.298327030319598 3380 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1596 piperlongumine 63 µM -0.530424478093541 0.300594842381475 no 2360 0.297908829097347 3456 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3175 9106517 49.47 µM -0.532952935085213 0.299649510577284 no 2361 0.297033080249626 3399 41468073 SGTC_920 mycophenolic acid 780.421 nM -0.535498809085808 0.298699030151638 no 2362 0.296152490439856 3344 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1075 aripiprazole 15.2 µM -0.536204859575504 0.298435675171849 no 2363 0.295908487662485 3356 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3211 9128781 49.47 µM -0.537838789298954 0.297826629239032 no 2364 0.295344175017345 3349 17194361 SGTC_2353 9059630 146.67 µM -0.538375345810438 0.297626751957454 no 2365 0.29515897179148 3400 4779114 SGTC_1668 st014914 51.6 µM -0.538868273760085 0.297443181101223 no 2366 0.294988874980856 3437 2839556 SGTC_1737 st035557 69.7 µM -0.539975891614334 0.297030882880414 no 2367 0.294606829275172 3357 5716916 SGTC_2218 6965428 192.983 µM -0.540402566172686 0.29687212787028 no 2368 0.294459719243122 3411 675684 SGTC_159 3970-0959 50 µM -0.54054467596165 0.296819260967421 no 2369 0.294410729766156 3513 6615653 SGTC_391 gliotoxin 8.33 µM -0.54075092278498 0.296742541823682 no 2370 0.294339637037159 3490 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2585 alliin 100 µM -0.542083881352324 0.296246930543933 no 2371 0.293880361076782 3527 87310 A garlic compound which reacts with lipids. SGTC_2981 9013952 38.96 µM -0.542654107973913 0.296035028900087 no 2372 0.29368398859802 3376 2996344 SGTC_1813 st051246 8.6015 µM -0.543495950334791 0.295722319498174 no 2373 0.293394189192313 3396 5291959 SGTC_3350 9150499 3.57 µM -0.54402390781941 0.295526282744192 no 2374 0.293212510484146 3409 4910996 YPR165W RHO1 SGTC_2818 7996756 12.99 µM -0.544069652158619 0.295509300152548 no 2375 0.293196771572918 3351 2241621 SGTC_2936 9038235 15.59 µM -0.544142793144583 0.295482147484868 no 2376 0.293171607317067 3394 4749415 SGTC_1281 0884-0031 11.8 µM -0.544811362347685 0.295234002806863 no 2377 0.292941631601064 3393 1548255 SGTC_325 2810-4341 181 µM -0.545399097156753 0.295015939707551 no 2378 0.292739530627405 3453 774970 SGTC_952 1185-0122 232 µM -0.546183605623556 0.294724984741188 no 2379 0.292469867173663 3400 678600 SGTC_1442 4112-3290 3 µM -0.546527206163529 0.294597593404362 no 2380 0.292351795822784 3398 704353 SGTC_280 3448-3607 3.04 µM -0.54708281652564 0.2943916523092 no 2381 0.292160918514129 3447 626179 SGTC_285 1486-1325 46 µM -0.547450498759741 0.294255404723783 no 2382 0.292034634918542 3456 22310230 SGTC_2383 9036125 200 µM -0.547511616883439 0.294232759738924 no 2383 0.292013645841573 3364 79580 SGTC_1660 st012960 28.1 µM -0.547778031176931 0.29413405950868 no 2384 0.291922162524411 3400 24207266 SGTC_1921 5740136 50 µM -0.548304554277629 0.293939040095335 no 2385 0.291741400382124 3461 1774243 SGTC_73 0327-0325 16.231 µM -0.548625337893692 0.293820254053326 no 2386 0.291631296823184 3434 53298 SGTC_1632 st005650 90 µM -0.549685994891944 0.293427651397483 no 2387 0.291267382208212 3412 2759605 SGTC_1637 st007924 17.4 µM -0.55123711952268 0.29285393992513 no 2388 0.290735568663006 3418 683336 SGTC_2283 7944793 200 µM -0.551370387437242 0.292804672678887 no 2389 0.290689898050018 3411 2970533 SGTC_2198 6589944 200 µM -0.551391676262349 0.292796802860511 no 2390 0.290682602728624 3418 5290268 SGTC_1035 k081-0041 55.2 µM -0.552644657716541 0.29233378756628 no 2391 0.290253378033515 3495 731709 SGTC_509 pifithrin 175 µM -0.552859146108797 0.292254561635151 no 2392 0.290179932084034 3487 4817 A p53 inhibitor. SGTC_1767 st044992 70.3 µM -0.553670554496316 0.291954940778997 no 2393 0.289902165276939 3399 9600693 SGTC_2113 5491891 107.031 µM -0.553685396145278 0.291949461680478 no 2394 0.289897085744772 3408 789979 SGTC_3098 9119039 49.47 µM -0.553784886359944 0.291912734067588 no 2395 0.289863036445348 3450 17161528 SGTC_3310 9130229 44.1445 µM -0.554023840014603 0.291824531195988 no 2396 0.289781265166884 3446 7761258 SGTC_997 3996-0078 137 µM -0.554066980324592 0.291808608514071 no 2397 0.289766503464723 3383 735687 SGTC_1016 4226-1401 38 µM -0.555899968907307 0.291132443978682 no 2398 0.289139619750014 3444 2901613 SGTC_2571 chrysanthemic acid 100 µM -0.555999520026889 0.291095741883321 no 2399 0.289105591444812 3378 2743 An insecticide. SGTC_1175 0741-0056 27.6 µM -0.556216040820165 0.291015923354374 no 2400 0.289031587372762 3512 765927 SGTC_1065 prochlorperazine maleate 2.48 µM -0.556255787657023 0.291001272135531 no 2401 0.289018003374078 3489 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1881 5652484 16 µM -0.556384596538868 0.29095379381684 no 2402 0.288973983326454 3450 2255129 SGTC_346 4513-0042 7.16 µM -0.558502639947262 0.290173613089786 no 2403 0.28825060116121 3434 2827372 SGTC_2352 9027995 87.8 µM -0.559510025300389 0.289802887254906 no 2404 0.287906845577733 3391 2997347 SGTC_1777 st045864 34.765 µM -0.559583487273736 0.289775861358603 no 2405 0.287881785323777 3473 4691462 SGTC_1484 3473-2379 286 µM -0.559703243044991 0.289731806990583 no 2406 0.287840934967306 3525 671917 SGTC_2844 9010103 25.97 µM -0.561089343115404 0.28922213338661 no 2407 0.287368316335865 3488 2480525 SGTC_1810 st050138 53 µM -0.561113939550159 0.289213093002854 no 2408 0.287359933003901 3460 3444541 SGTC_2427 5545055 42.75 µM -0.56189575944184 0.288925805483841 no 2409 0.287093521532693 3435 5372858 SGTC_2291 7917025 104.35 µM -0.562550064480635 0.288685477837467 no 2410 0.286870651716719 3360 2964612 SGTC_2119 5528445 120.635 µM -0.563152063733347 0.28846444540967 no 2411 0.286665670776503 3475 791935 SGTC_2806 7952793 58.44 µM -0.563282483425569 0.288416570513077 no 2412 0.286621271984152 3453 2972490 SGTC_557 1315-0110 16.2 µM -0.563561396029834 0.288314198913552 no 2413 0.286526332677519 3446 6833801 SGTC_1409 3909-8004 61.9 µM -0.564639796305593 0.28791854602711 no 2414 0.286159395487763 3431 2119279 SGTC_2225 6654152 15.4 µM -0.566164125138989 0.287359724701727 no 2415 0.285641107424045 3428 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3074 9116018 49.47 µM -0.568426364032713 0.286531331493923 no 2416 0.284872746452512 3434 17027303 SGTC_908 3448-7491 47.7 µM -0.568718796523485 0.286424330460435 no 2417 0.28477349486504 3476 1203031 SGTC_319 1348-1596 45.5 µM -0.569798557785429 0.286029410235175 no 2418 0.284407166920653 3524 5380505 SGTC_1234 0326-0494 15.5 µM -0.572024463386379 0.285216107864003 no 2419 0.283652700724191 3530 1547813 SGTC_1776 st049249 45.9 µM -0.572048566498383 0.285207307092533 no 2420 0.283644536272745 3435 1822314 SGTC_3135 9127742 49.47 µM -0.572733745621129 0.2849571817194 no 2421 0.283412492522388 3421 3643468 SGTC_2238 6671620 73.2395 µM -0.573260274977023 0.284765042728763 no 2422 0.283234239189164 3455 729941 SGTC_160 3453-0671 289.699 µM -0.573273348819866 0.28476027266099 no 2423 0.283229813802959 3409 5322268 SGTC_677 0929-0063 136 µM -0.573323465594001 0.284741987617075 no 2424 0.283212850002312 3443 1539583 SGTC_1824 st053723 68.6 µM -0.573754157730513 0.2845848732215 no 2425 0.283067087061095 3424 675225 SGTC_2054 5233173 129 µM -0.574973161005963 0.28414041129725 no 2426 0.282654724306129 3480 6889 SGTC_2959 9079155 11 µM -0.575184897274261 0.284063243790253 no 2427 0.282583127891089 3493 16189457 SGTC_205 1486-1330 71.903 µM -0.575262468536565 0.284034975371004 no 2428 0.282556900158377 3466 4118834 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.576646502706121 0.283530833779777 no 2429 0.282089139171545 3449 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1371 2421-0008 32.7 µM -0.578024757489364 0.283029223870036 no 2430 0.281623702274915 3419 2827552 SGTC_1868 st057644 42.7 µM -0.57882508952112 0.28273814208961 no 2431 0.281353600067263 3408 688665 SGTC_595 3909-8003 73.7 µM -0.579780491819227 0.282390849505211 no 2432 0.281031327365753 3524 699517 SGTC_234 nsc-17383 10.7 µM -0.579887998327854 0.282351783303708 no 2433 0.280995074842651 3532 408974 SGTC_2340 7987427 183.45 µM -0.580187942718247 0.282242801902404 no 2434 0.280893941837539 3468 2239331 SGTC_2029 5175081 200 µM -0.580227211701271 0.282228535460408 no 2435 0.280880702718352 3478 1380876 SGTC_3154 9100113 49.47 µM -0.582920901673992 0.281250745846697 no 2436 0.279973274608951 3407 25237525 SGTC_795 0685-0265 78 µM -0.58323025119302 0.28113855903989 no 2437 0.2798691545478 3560 302754 SGTC_1604 st002052 72.4 µM -0.583300419109606 0.281113115379553 no 2438 0.279845540225173 3539 6254834 YHR062C RPP1 SGTC_3179 9107801 49.47 µM -0.58409886642565 0.280823667946092 no 2439 0.279576898719094 3462 4818259 SGTC_663 1486-0733 13.9 µM -0.585189868698017 0.280428398692094 no 2440 0.279210028197154 3449 722445 YPR165W RHO1 SGTC_1806 st050005 60.3 µM -0.585354213685741 0.280368879984712 no 2441 0.279154784315939 3430 5194765 SGTC_1326 1431-2094 10.8 µM -0.58560515269084 0.280278012439547 no 2442 0.279070442469795 3449 616278 SGTC_471 1-acyl-paf 4 µM -0.586595048618645 0.279919700325299 no 2443 0.278737854435393 3434 16759367 SGTC_268 camptothecin 39.6153 µM -0.589044109055817 0.279034171002374 no 2444 0.277915842339984 3528 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1208 2323-2347 50.3 µM -0.589292043350837 0.278944599116597 no 2445 0.277832690716871 3502 5412760 SGTC_942 3253-1115 227 µM -0.589458532873942 0.278884458852359 no 2446 0.277776860668034 3540 46497897 SGTC_1460 k062-0059 9.15 µM -0.58961537501593 0.278827809240061 no 2447 0.277724270752022 3427 1373085 SGTC_2942 9052777 62.25 µM -0.58967170438447 0.27880746507447 no 2448 0.277705384433776 3550 6469503 SGTC_510 ag-490 170 µM -0.59010495450315 0.278651014683131 no 2449 0.277560143708 3586 5328779 SGTC_1530 rhein 70.4 µM -0.593496877029184 0.277427641507734 no 2450 0.276424336186296 3531 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_92 0063-0024 660.874 µM -0.59363404255959 0.277378224961829 no 2451 0.27637845340386 3533 3594437 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.59373257979781 0.277342727664852 no 2452 0.276345494348011 3517 6708760 SGTC_526 4469-0568 170 µM -0.593882239712245 0.277288818058644 no 2453 0.276295439301545 3519 2901964 SGTC_1574 spiramycin 23.7 µM -0.59392558196303 0.277273206527354 no 2454 0.276280943943446 3500 6419898 An antibiotic and protein synthesis inhibitor. SGTC_597 k018-0003 82.8 µM -0.593987276735524 0.277250985306352 no 2455 0.276260311421844 3542 6786234 SGTC_496 calpeptin 138 µM -0.594398288292076 0.277102969413798 no 2456 0.276122876533852 3474 73364 A calpain inhibitor. SGTC_1931 st074438 57.1 µM -0.595127746708437 0.276840367826182 no 2457 0.275879041405755 3474 2787313 SGTC_1826 st055655 41.6 µM -0.595257388137419 0.27679371028239 no 2458 0.275835717405014 3488 676168 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.59883849551051 0.275506405930388 no 2459 0.274640294431866 3559 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1962 st076595 64.5 µM -0.599105273696821 0.27541062488617 no 2460 0.274551342569077 3505 279619 SGTC_2134 5324836 1.464 µM -0.600105878686936 0.275051524936697 no 2461 0.274217837487371 3423 699272 SGTC_638 3970-0837 4.09 µM -0.600412860040168 0.274941400850839 no 2462 0.274115559669421 3476 4118451 YLR208W SEC13 SGTC_1838 st055369 84.5 µM -0.601973194588266 0.27438199474415 no 2463 0.273595990262394 3501 676036 SGTC_1355 1499-0035 1.68 µM -0.602995989106369 0.274015610846299 no 2464 0.273255678726191 3516 1548538 SGTC_1879 gemcitabine 100 µM -0.603686703038784 0.273768321194744 no 2465 0.273025978105575 3508 60750 A nucleoside analog which inhibits DNA replication. SGTC_741 4582-0002 126 µM -0.605022149364834 0.273290517435001 no 2466 0.272582139886322 3494 2912688 SGTC_1127 asiatic acid 681.4 nM -0.605648088112346 0.273066707684193 no 2467 0.272374231262973 3479 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2865 9030313 51.95 µM -0.605789516588099 0.273016151308893 no 2468 0.272327266013746 3453 42562754 SGTC_2456 5770359 74.46 µM -0.607140114571597 0.272533587509898 no 2469 0.271878965249209 3535 3118787 SGTC_1080 nisoldipine 24.4 µM -0.607159534625632 0.272526651884043 no 2470 0.271872521875586 3476 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2730 imipramine 71.33 µM -0.608621673687965 0.272004719292349 no 2471 0.271387617517832 3551 3696 A tricyclic antidepressant. SGTC_1651 st011928 86.1 µM -0.610867802431576 0.27120389935845 no 2472 0.27064355097741 3535 720198 SGTC_2144 5628481 200 µM -0.611616411473392 0.270937256634903 no 2473 0.27039578866492 3513 2818399 SGTC_1472 k841-0093 193 µM -0.611651375045953 0.270924806360347 no 2474 0.270384219768051 3601 X1472 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.61281669141494 0.270510009047165 no 2475 0.269998776481263 3531 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2661 dactinomycin 12.96 µM -0.613296467731229 0.27033932370994 no 2476 0.269840164275844 3549 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2892 9047358 58.44 µM -0.613801106909067 0.270159851268493 no 2477 0.269673382858395 3486 6466771 SGTC_1677 st019204 53.9 µM -0.614062762424591 0.27006681823747 no 2478 0.269586926992126 3498 3945625 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.614109257234859 0.27005028843399 no 2479 0.269571565692239 3609 688664 SGTC_2797 7859098 81.82 µM -0.614576042197298 0.269884365416835 no 2480 0.269417370126946 3515 972681 SGTC_398 bronopol 33.3 µM -0.614711529061449 0.269836214920052 no 2481 0.269372622309705 3483 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_380 3970-0968 6 µM -0.61680722770872 0.269091975587505 no 2482 0.268680942042594 3510 2891601 SGTC_2323 6148992 148.28 µM -0.616838511924115 0.269080873523616 no 2483 0.268670623527017 3471 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2666 tannic acid 100 µM -0.617045494082524 0.269007426006245 no 2484 0.268602359335522 3563 16134267 A thiamine antagonist. SGTC_1447 4239-0816 81.9 µM -0.61729066511241 0.268920440207759 no 2485 0.26852151146119 3477 1341554 SGTC_1369 1866-0067 208 µM -0.617912822340942 0.268699764472199 no 2486 0.26831640311866 3565 3531355 SGTC_137 0438-0332 85.389 µM -0.618836063855361 0.268372463566642 no 2487 0.268012180773802 3570 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3356 9151811 4.48 µM -0.619853503569186 0.268012000581212 no 2488 0.267677119934263 3504 1859254 YPR165W RHO1 SGTC_2187 6125751 200 µM -0.620467108427286 0.267794727867467 no 2489 0.267475151135891 3525 874498 SGTC_3097 9117246 49.47 µM -0.621454065293782 0.267445440367152 no 2490 0.267150454358722 3581 16423892 SGTC_680 0417-1641 114 µM -0.621565378340642 0.267406060712432 no 2491 0.267113846213115 3504 2835990 SGTC_2561 acetosyringone 100 µM -0.621996911509631 0.267253423177514 no 2492 0.266971949425924 3501 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2241 6772625 37.8075 µM -0.622400170987712 0.267110826077552 no 2493 0.266839384017616 3517 2285411 SGTC_611 3453-1652 23.7 µM -0.624710970744075 0.266294442629314 no 2494 0.266080385735297 3570 1560575 SGTC_393 acivicin 6.25 µM -0.625419103956436 0.266044518967541 no 2495 0.265848013503655 3482 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_963 1269-2853 151 µM -0.626301955978729 0.265733097726302 no 2496 0.265558451819129 3532 3668223 SGTC_141 0443-0274 32.331 µM -0.629070617601536 0.264757667464489 no 2497 0.264651412726979 3663 1627241 SGTC_2952 9073731 13.78 µM -0.629175049736475 0.264720910524459 no 2498 0.264617230660636 3533 16457353 SGTC_1272 0839-0021 27 µM -0.629342520050456 0.264661971477638 no 2499 0.264562420024647 3550 5027250 SGTC_2974 9094440 9.66 µM -0.629498020150233 0.264607251171755 no 2500 0.264511532240317 3586 25236134 SGTC_1404 3909-7820 48.3 µM -0.629526719811194 0.264597152423297 no 2501 0.264502140751216 3562 23741373 SGTC_2603 homopterocarpin 100 µM -0.632561604673913 0.263530354224383 no 2502 0.263509983479485 3567 101795 A weak amylase inhibitor. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.634486441953017 0.262854890345329 no 2503 0.262881706108102 3542 5711223 A potent inhibitor of glutathione S-transferases. SGTC_926 2268-1401 59.4 µM -0.636688047595088 0.262083389792929 no 2504 0.26216403027296 3572 2931578 SGTC_1741 st038134 10.228 µM -0.637138361303001 0.261925731109652 no 2505 0.262017361512303 3641 1272587 SGTC_2786 7743617 45.45 µM -0.638182119574139 0.261560489491969 no 2506 0.261677567581049 3479 583674 SGTC_414 piperonyl butoxide 100 µM -0.638322266822511 0.261511467777538 no 2507 0.261631960080933 3516 5794 A potent inhibitor of cytochrome P450. SGTC_2931 9014674 55.67 µM -0.638405676425513 0.26148229440476 no 2508 0.261604818398778 3567 2996810 SGTC_3072 9116419 49.47 µM -0.638432148765828 0.261473035778818 no 2509 0.261596204538734 3534 17170162 SGTC_3146 9095609 49.47 µM -0.640346914838587 0.260803798471934 no 2510 0.260973543290109 3569 17173999 SGTC_1743 st037606 46.3785 µM -0.640899187788507 0.260610935286307 no 2511 0.260794091801865 3594 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2885 9057732 51.95 µM -0.641368719791572 0.260447024418622 no 2512 0.260641575490744 3603 6471414 SGTC_836 0330-0104 1.35 µM -0.641778872246821 0.260303886061015 no 2513 0.260508384791862 3590 46494820 SGTC_2307 7538926 6.34 µM -0.642331526193696 0.260111080488104 no 2514 0.260328974368109 3558 96582 SGTC_2202 7226349 200 µM -0.644333533300205 0.259413252869594 no 2515 0.259679587585277 3542 844334 SGTC_2472 5377652 49.4 µM -0.644841880678973 0.259236215353176 no 2516 0.259514829238588 3552 1610903 SGTC_657 3534-0529 86.7 µM -0.645623683191582 0.258964066020908 no 2517 0.259261547883134 3612 1049549 SGTC_709 3807-1509 243 µM -0.647069301389427 0.258461228704563 no 2518 0.258793546219968 3631 1886677 YPL242C IQG1 SGTC_924 2046-0044 21.3 µM -0.649443181060343 0.257636607633493 no 2519 0.258025980471778 3610 3623589 SGTC_2135 5326629 150.42 µM -0.650217269027901 0.257368006248452 no 2520 0.257775943870568 3563 5020077 SGTC_2630 antimycin a 100 µM -0.650383369372642 0.25731038992908 no 2521 0.257722308523783 3590 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2923 7992654 58.14 µM -0.650995297077718 0.257098184396368 no 2522 0.257524761371775 3605 2985126 SGTC_2695 st077686 51.995 µM -0.651191268475101 0.257030244282983 no 2523 0.257461513027405 3573 2876092 SGTC_621 3584-0052 32.1 µM -0.651206673285819 0.257024904080226 no 2524 0.257456541578828 3621 2273927 SGTC_2194 5927483 104.545 µM -0.652073917253818 0.25672436002093 no 2525 0.257176744606295 3616 760979 SGTC_2803 7707263 71.43 µM -0.654101130596616 0.256022542042307 no 2526 0.256523326569654 3586 2199229 SGTC_269 exalamide 29 µM -0.65463042981853 0.255839464423572 no 2527 0.256352863600776 3568 3316 A derivative of salicylamide. SGTC_2253 7938677 135.83 µM -0.655719837687272 0.255462867773619 no 2528 0.256002201249412 3637 2301972 SGTC_1014 4130-3005 69.3 µM -0.65596977261978 0.255376508807563 no 2529 0.255921786639491 3627 743608 SGTC_106 0092-0003 11.579 µM -0.656647188177973 0.255142520999752 no 2530 0.255703899776097 3554 1072148 SGTC_1406 3909-7906 11.9 µM -0.657447213730804 0.25486632663468 no 2531 0.255446700903831 3621 X1406 SGTC_815 1582-0027 36.9 µM -0.659537063330408 0.254145582800958 no 2532 0.254775476981315 3626 3128206 SGTC_2214 7179297 48.276 µM -0.659606809630976 0.25412154726039 no 2533 0.2547530915966 3621 769744 SGTC_2881 9058953 51.95 µM -0.660466079198364 0.253825528928663 no 2534 0.254477389731337 3581 17122249 SGTC_504 lovastatin 124 µM -0.660519843322489 0.253807013209241 no 2535 0.254460144383824 3564 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1443 4112-3303 14 µM -0.660546835084184 0.253797717837647 no 2536 0.254451486753783 3611 704433 SGTC_1394 3474-0001 65.7 µM -0.66116128451116 0.253586163264142 no 2537 0.254254443347702 3543 5017666 YIL048W NEO1 SGTC_770 0389-1121 67.2 µM -0.661835063587699 0.253354288054076 no 2538 0.254038465938197 3676 6753108 SGTC_407 eburnamonine 100 µM -0.663277529167573 0.252858251021601 no 2539 0.25357641269388 3522 3195 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.664050548260333 0.25259263470459 no 2540 0.253328979598798 3624 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1006 4099-6547 255 µM -0.664556712092104 0.252418791920676 no 2541 0.253167032100296 3620 3146833 SGTC_115 0527-0192 112.043 µM -0.665494041411173 0.25209703123868 no 2542 0.252867276717272 3637 4233931 SGTC_40 0327-0103 19.753 µM -0.666011412176327 0.251919524079186 no 2543 0.252701902997879 3553 409036 SGTC_405 ebelactone b 50 µM -0.666705283678849 0.251681564056333 no 2544 0.252480201578199 3614 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_251 melphalan 456.522 µM -0.669744827377202 0.250640567207382 no 2545 0.251510235039006 3679 460612 A DNA alkylator. SGTC_176 1486-1328 72.834 µM -0.670058094833316 0.25053340772428 no 2546 0.251410378474758 3623 22310231 SGTC_3331 9141060 1.957 µM -0.670247374783254 0.250468672447371 no 2547 0.251350054099346 3618 4906567 YPR165W RHO1 SGTC_3302 9125395 16.351 µM -0.67259751250589 0.249665645147997 no 2548 0.250601692335703 3600 17599668 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.673056993399157 0.24950880337587 no 2549 0.250455516454101 3609 688803 SGTC_556 4058-0063 51.5 µM -0.673443261861486 0.249376992860436 no 2550 0.250332666807512 3690 6615692 SGTC_1368 1852-0141 284 µM -0.673995320594735 0.249188672230828 no 2551 0.250157144339143 3617 2838987 SGTC_3122 9126309 49.47 µM -0.67404742356469 0.249170902550287 no 2552 0.250140582006258 3675 17591206 SGTC_2966 9084041 48.03 µM -0.674490759476595 0.249019730423703 no 2553 0.249999679274407 3557 17741380 SGTC_2334 9017922 200 µM -0.674674549059969 0.248957074734235 no 2554 0.249941278910452 3645 3163164 SGTC_246 cycloheximide 667 µM -0.676204349062392 0.248435876467979 no 2555 0.249455455853351 3523 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2723 salbutamol 83.58 µM -0.676240125860093 0.248423694383173 no 2556 0.249444100119699 3612 9884233 β2-adrenoceptor agonist SGTC_2824 7998404 51.95 µM -0.676669376361919 0.248277558393035 no 2557 0.249307875298717 3611 837851 SGTC_548 1436-0017 110 µM -0.676940495395212 0.248185281020723 no 2558 0.249221854684631 3691 9677137 SGTC_2377 9073351 62.6 µM -0.676976471375321 0.248173037703991 no 2559 0.249210441416278 3603 7337946 YHR072W ERG7 SGTC_203 k066-0004 30.888 µM -0.677207476126886 0.24809443002733 no 2560 0.249137162496811 3703 6795412 SGTC_827 3253-0474 693 µM -0.677346243987122 0.248047215657593 no 2561 0.249093148312154 3637 5402065 SGTC_3085 9117376 49.47 µM -0.677485335073822 0.247999896124272 no 2562 0.24904903575834 3677 16480349 SGTC_688 0527-0193 473 µM -0.677859892671186 0.247872493575531 no 2563 0.248930265981958 3644 4007154 SGTC_55 0767-0285 6.563 µM -0.678488434422628 0.247658779023736 no 2564 0.248731027239603 3614 3116166 SGTC_1255 0566-0045 221 µM -0.679517217421436 0.247309188328635 no 2565 0.248405101079713 3668 2788469 SGTC_17 0960-0276 49.807 µM -0.683186206900856 0.246064580323595 no 2566 0.247244593629662 3653 6821114 SGTC_1444 4112-3581 28 µM -0.683337794251376 0.246013230686374 no 2567 0.247196708739199 3681 2877249 SGTC_1278 0874-0585 172 µM -0.683386082831168 0.245996874321497 no 2568 0.247181455913362 3665 766306 SGTC_2712 st079126 47.7 µM -0.683501119018185 0.245957911478839 no 2569 0.247145121670097 3631 3152970 SGTC_838 0109-0203 71.4 µM -0.684259874644196 0.245701003352409 no 2570 0.246905539860317 3656 759422 SGTC_1314 1222-0010 41.1 µM -0.684624186298967 0.245577701781812 no 2571 0.246790550372597 3658 3526027 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.686410979962062 0.244973441600697 no 2572 0.24622699124292 3687 6708784 An antioxidant flavonoid SGTC_3078 9116413 49.47 µM -0.687125677086623 0.244731968576329 no 2573 0.246001767361066 3602 17177322 SGTC_2152 5568786 200 µM -0.687198833749814 0.244707258539843 no 2574 0.245978719598482 3635 5399883 SGTC_66 0109-0187 42.4 µM -0.688332507957855 0.244324510550689 no 2575 0.245621707461594 3648 759417 SGTC_3159 9100096 49.47 µM -0.688755250971425 0.244181867847006 no 2576 0.2454886501982 3628 25236875 SGTC_2424 5537928 59.2 µM -0.689032667550965 0.244088285855902 no 2577 0.24540135510149 3712 5382802 SGTC_48 0382-0018 55 µM -0.689285392077908 0.244003050168857 no 2578 0.245321844413685 3750 762596 SGTC_2788 5282734 71.43 µM -0.691314441539969 0.243319300714398 no 2579 0.244683979130283 3700 743706 SGTC_60 0986-0278 202 µM -0.692760238935249 0.242832728166728 no 2580 0.24423001424028 3499 3110598 SGTC_1638 st008370 60.6 µM -0.693177194311247 0.242692502768884 no 2581 0.244099179127936 3672 24207134 SGTC_673 1082-0474 110 µM -0.693940536557704 0.242435898350622 no 2582 0.243859750351391 3687 3098046 SGTC_2875 9039966 71.43 µM -0.694944282791446 0.242098703779091 no 2583 0.243545109816557 3707 6463691 SGTC_3275 9138069 49.47 µM -0.696195832784919 0.241678619457017 no 2584 0.243153098527741 3710 17617007 SGTC_3123 9126162 49.47 µM -0.699653084547453 0.240520247595885 no 2585 0.242071991089521 3741 25239884 SGTC_364 0083-0097 67.7 µM -0.70029647381219 0.240305010517273 no 2586 0.241871086715902 3706 5207356 SGTC_272 doxorubicin 8.13 µM -0.700656437019074 0.240184635545856 no 2587 0.241758724282985 3685 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1018 4259-0013 28.1 µM -0.701013739588752 0.240065182823236 no 2588 0.241647220389378 3708 6801262 SGTC_3272 9137413 49.47 µM -0.701060565500107 0.240049530473491 no 2589 0.241632609433743 3635 17614870 SGTC_401 neomycin 50 µM -0.701245089078055 0.239987855775636 no 2590 0.241575037736967 3660 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1173 0443-0020 122 µM -0.703766664702998 0.239145917098693 no 2591 0.240789048332362 3688 5331295 SGTC_1740 st038286 13.222 µM -0.704568810029493 0.238878424511565 no 2592 0.240539307140606 3695 716786 SGTC_2146 5545642 200 µM -0.704916030630533 0.238762687110389 no 2593 0.240431246685439 3688 825326 SGTC_2694 st077685 81.9 µM -0.705417430477272 0.238595612018348 no 2594 0.240275249918443 3662 2838096 SGTC_1056 3448-1962 115 µM -0.705481036601617 0.238574421933164 no 2595 0.240255464565441 3692 715507 SGTC_971 1315-0384 26.7 µM -0.705768069227515 0.238478811159223 no 2596 0.240166191096035 3690 6769120 SGTC_1155 4088-0394 48.2 µM -0.706275433755027 0.238309858995339 no 2597 0.240008433786106 3659 2326248 SGTC_342 k048-0088 23.3 µM -0.706650134730198 0.238185125835816 no 2598 0.239891962480432 3677 6820570 SGTC_2161 5662504 8.5105 µM -0.706660466448956 0.238181687045688 no 2599 0.239888751426329 3667 2859334 SGTC_1431 4049-0260 9.09 µM -0.708297239294688 0.237637250256689 no 2600 0.239380345572931 3661 3854841 SGTC_1015 4130-4525 82 µM -0.708541180188491 0.237556167147336 no 2601 0.239304624345629 3701 1363237 SGTC_1731 st035964 63 µM -0.708956856205288 0.237418036271953 no 2602 0.239175625297064 3684 6739575 SGTC_1963 st076565 50.3 µM -0.708979518542348 0.23741050675054 no 2603 0.239168593460576 3706 4914280 SGTC_3285 9112818 20.8695 µM -0.709348170510648 0.237288041200453 no 2604 0.239054221287339 3719 17017947 YPR165W RHO1 SGTC_1534 6-azauridine 81.6 µM -0.710408611351349 0.23693595809282 no 2605 0.238725392317626 3728 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1965 Pectolinarigenin 58.4 µM -0.710661275513533 0.236852111983525 no 2606 0.238647080955919 3698 5320438 An anti-inflammatory. SGTC_1839 st053978 48 µM -0.711780151288648 0.236481011394432 no 2607 0.238300462828229 3727 3788398 SGTC_581 0958-0271 211 µM -0.713437322639499 0.235931961303419 no 2608 0.237787592405061 3709 4591145 SGTC_2088 5278280 127.392 µM -0.713691726436565 0.235847735092061 no 2609 0.237708911770619 3747 791502 SGTC_2945 9067681 61.76 µM -0.71395943827904 0.235759120849235 no 2610 0.237626130720515 3771 16456930 SGTC_2136 5328288 199.296 µM -0.714147152108817 0.23569699738472 no 2611 0.237568095850736 3702 262395 SGTC_1461 k072-0203 53.8 µM -0.715033004890959 0.235403948287613 no 2612 0.237294324646278 3640 5418714 SGTC_3028 9087778 49.47 µM -0.715363524495582 0.23529466057966 no 2613 0.237192222559731 3678 17217395 SGTC_416 estradiol valerate 100 µM -0.715449262433606 0.235266315543262 no 2614 0.237165740865132 3715 13791 A steroid. SGTC_158 k038-0087 26.446 µM -0.716079939820468 0.235057871003135 no 2615 0.236970994808615 3651 X158 SGTC_2387 9077560 195.08 µM -0.716458910597864 0.234932666844398 no 2616 0.236854015202049 3699 5303272 SGTC_854 0422-0053 192 µM -0.717829944685578 0.23448001332774 no 2617 0.236431073687355 3723 3596728 SGTC_2706 st078239 82.5 µM -0.718334804074009 0.234313453195816 no 2618 0.236275437637901 3708 15434492 SGTC_1465 k213-0056 144 µM -0.71907280066302 0.234070095730237 no 2619 0.236048032521482 3610 24048857 YMR208W ERG12 SGTC_1363 1636-0063 10.4 µM -0.719246805437385 0.234012737327265 no 2620 0.23599443253624 3732 6072185 SGTC_2224 6650123 117.647 µM -0.71937061861608 0.233971928670061 no 2621 0.235956297526121 3680 2908370 SGTC_2924 9010168 62.78 µM -0.71969725633458 0.233864288238813 no 2622 0.235855707955222 3762 2993929 SGTC_843 0310-0051 143 µM -0.720276268089332 0.23367354773609 no 2623 0.235677456758968 3724 2065037 SGTC_572 0960-0087 17.7 µM -0.720760804630791 0.233513995966773 no 2624 0.235528347274541 3727 6796365 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.721073413247474 0.23341108996859 no 2625 0.235432173884556 3651 1241132 A phosphatase inhibitor. SGTC_1074 carmofur 3.8 µM -0.721832237261451 0.233161401339853 no 2626 0.235198813435322 3736 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1827 berberine 7.24 µM -0.725186184206942 0.232059573701547 no 2627 0.234168908708813 3659 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2268 7933382 153.85 µM -0.726532124379824 0.231618226215297 no 2628 0.233756310715841 3749 935025 YOR257W CDC31 SGTC_210 3551-0445 56.827 µM -0.726621027580409 0.231589090430893 no 2629 0.233729071631936 3737 2865180 YOR207C RET1 SGTC_1441 4106-0040 13 µM -0.727220832559519 0.231392572852083 no 2630 0.233545343153329 3704 2904180 SGTC_3115 9123671 49.47 µM -0.727437737592369 0.231321529901721 no 2631 0.233478921896215 3794 3286988 SGTC_2930 9013230 14.89 µM -0.727464206713333 0.231312861298009 no 2632 0.23347081716643 3710 2995857 SGTC_1953 st076800 12.1 µM -0.729310789553602 0.230708555187322 no 2633 0.232905786886185 3748 297591 SGTC_3082 9117008 49.47 µM -0.729350929706746 0.230695428865451 no 2634 0.232893512963879 3778 41448529 SGTC_2085 5307070 144.047 µM -0.731577932684307 0.229967825637921 no 2635 0.232213110669871 3698 2840351 SGTC_1283 0922-0125 16.4 µM -0.731614373015329 0.229955930594952 no 2636 0.232201986489424 3733 3360884 SGTC_253 dyclonine 31.25 µM -0.732532332380522 0.229656399135993 no 2637 0.231921857862717 3798 3180 An oral anasthetic. SGTC_1001 4048-4355 44.4 µM -0.732537841884952 0.229654602036797 no 2638 0.231920177125832 3723 21824233 SGTC_566 0958-0068 16.5 µM -0.732802783765682 0.229568192156958 no 2639 0.231839361603453 3697 6815365 SGTC_2451 5856223 45.7 µM -0.732929807060952 0.229526770408658 no 2640 0.231800621107501 3703 2179896 SGTC_618 k072-0232 33.2 µM -0.735381846108645 0.228727992215879 no 2641 0.231053487383222 3734 5872756 YGL099W LSG1 SGTC_2617 dihydrotanshinone i 20.83 µM -0.736271780207064 0.228438473053265 no 2642 0.23078265819634 3761 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.73898532153348 0.227556958395898 no 2643 0.229957955287724 3718 641818 YHR062C RPP1 SGTC_1184 1269-1718 139 µM -0.739382218148633 0.227428184262815 no 2644 0.229837468395046 3768 5403821 SGTC_1214 0358-0031 63.7 µM -0.740648012608566 0.227017768311486 no 2645 0.229453444227586 3825 4301366 SGTC_316 k060-0003 58.6 µM -0.741844444206383 0.226630226509794 no 2646 0.229090794586717 3727 6152314 SGTC_1983 st071813 46.9 µM -0.742024333513616 0.226571990025572 no 2647 0.229036296268139 3798 11838595 SGTC_1896 st058441 89 µM -0.742218867189653 0.226509022153456 no 2648 0.228977369555043 3768 688759 SGTC_2171 5739187 198.077 µM -0.742427798137623 0.226441405088226 no 2649 0.228914091201422 3678 2262761 SGTC_3050 9093513 49.47 µM -0.742967385811612 0.226266829153248 no 2650 0.228750713143985 3750 25236664 SGTC_3140 9094243 49.47 µM -0.743482255151477 0.226100321398048 no 2651 0.22859488043486 3762 19291112 SGTC_2789 5281112 71.43 µM -0.744383490197929 0.225809030483758 no 2652 0.228322252091342 3774 765948 SGTC_2552 juarezic acid 87.02 µM -0.74606856095045 0.225264963495772 no 2653 0.227812999913775 3789 1549512 SGTC_921 1561-0023 372 µM -0.747567516026114 0.224781613159933 no 2654 0.227360532221546 3735 24050882 SGTC_1774 st048371 48.465 µM -0.748633287964628 0.224438304290055 no 2655 0.22703913140924 3744 4242727 SGTC_906 1165-0455 526 µM -0.74961527791027 0.224122247035836 no 2656 0.226743223312191 3728 3252859 SGTC_658 3253-0951 102 µM -0.75111994238534 0.223638455734332 no 2657 0.226290237474069 3764 1184878 SGTC_880 0833-0487 87.2 µM -0.751939729368366 0.223375121623721 no 2658 0.226043652307479 3736 76075 SGTC_2710 st078562 53.7235 µM -0.753647689898187 0.222827053202451 no 2659 0.225530400029324 3734 17250908 SGTC_1842 st055362 61.2 µM -0.753782884006985 0.222783703437796 no 2660 0.225489801587455 3755 676032 SGTC_3245 9134821 49.47 µM -0.754436418651798 0.222574216426863 no 2661 0.22529360516321 3769 17014901 SGTC_2611 pyromycin 23.93 µM -0.754906539018941 0.222423591352853 no 2662 0.225152531003914 3770 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.755527242442326 0.222224809027776 no 2663 0.224966346419184 3760 4330530 SGTC_2728 chlorpromazine 9.18 µM -0.756044490894161 0.222059235965845 no 2664 0.224811260598203 3773 2726 A thorazine and dopamine antagonist. SGTC_2109 5483026 200 µM -0.757414099109473 0.221621159803447 no 2665 0.224400905932473 3764 759335 SGTC_2313 7726885 200 µM -0.757630331647285 0.221552041895873 no 2666 0.224336158379683 3771 726423 SGTC_1164 k060-0068 93.7 µM -0.759473974914828 0.220963228933131 no 2667 0.223784538242748 3789 5963676 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.759513107171045 0.22095074079731 no 2668 0.223772838190103 3759 6857784 SGTC_615 k087-0205 167 µM -0.762178756702238 0.220101013263484 no 2669 0.222976661519291 3772 9642773 SGTC_5 0352-0601 109.883 µM -0.7624710297075 0.220007959735152 no 2670 0.222889463627065 3689 762456 SGTC_2601 securinine 100 µM -0.762531372410946 0.219988750709182 no 2671 0.222871463164381 3742 442872 A GABA receptor antagonist. SGTC_647 0140-0236 81 µM -0.763308806137633 0.219741354592732 no 2672 0.222639625749888 3774 990837 SGTC_2110 5483698 200 µM -0.765586070662712 0.219017599972816 no 2673 0.221961317611634 3785 2848765 YHR062C RPP1 SGTC_2069 5228469 200 µM -0.766516344330267 0.218722337549978 no 2674 0.22168456526946 3739 2835210 SGTC_1129 3453-1384 223 µM -0.766569378753311 0.218705511696462 no 2675 0.221668793703727 3918 1084452 SGTC_483 fpl-64176 144 µM -0.766656367525763 0.218677915001614 no 2676 0.221642926060897 3798 3423 SGTC_488 nitrendipine 139 µM -0.766889275421159 0.21860403616063 no 2677 0.221573675290999 3815 4507 Dihydropyridine L-type calcium channel blocker. SGTC_298 1391-0729 10 µM -0.768167577863624 0.218198812056882 no 2678 0.22119381643359 3739 3237558 SGTC_1149 3909-7961 23.3 µM -0.769118111510396 0.217897772044262 no 2679 0.220911598637228 3808 735261 SGTC_981 1488-1094 54.9 µM -0.769531735733527 0.217766849464119 no 2680 0.22078885610435 3760 3449522 SGTC_639 0833-0042 114 µM -0.770046022722046 0.217604127864795 no 2681 0.220636296486545 3766 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2481 5478948 45.16 µM -0.770255350073064 0.217537916301757 no 2682 0.220574218296166 3805 77792 SGTC_1205 4161-2785 76 µM -0.770515727293643 0.217455573572556 no 2683 0.22049701470648 3869 3498106 SGTC_2066 5222451 176 µM -0.771413172726947 0.217171899780613 no 2684 0.22023103482256 3782 2281147 SGTC_3121 9125696 49.47 µM -0.772388322677567 0.216863906825333 no 2685 0.219942233980334 3841 1235365 SGTC_1386 3228-0095 33.8 µM -0.772583512664823 0.216802288045774 no 2686 0.21988445254145 3782 870181 SGTC_2449 5812982 45.77 µM -0.773592255631808 0.216484003229862 no 2687 0.219585976621625 3749 776185 SGTC_1578 josamycin 24.2 µM -0.77379579507272 0.216419814005536 no 2688 0.219525779770587 3792 5282165 A P450 substrate. SGTC_2145 5634607 200 µM -0.773827857813002 0.216409703542421 no 2689 0.219516298069758 3771 308662 SGTC_3221 9128209 49.47 µM -0.773909020241608 0.216384111513853 no 2690 0.219492297496293 3831 16460723 SGTC_369 0957-0393 4.5 µM -0.773938741968346 0.21637474013688 no 2691 0.219483508849967 3803 6997992 SGTC_2781 5567276 71.43 µM -0.774327250327985 0.216252263534146 no 2692 0.219368646413958 3826 2853274 SGTC_1908 st060353 56.5 µM -0.774924194060224 0.216064156269875 no 2693 0.219192227419835 3824 4227716 SGTC_2868 9035608 32.47 µM -0.776358824240153 0.215612467351957 no 2694 0.218768574752834 3769 6462614 SGTC_330 1488-0319 80.1 µM -0.777139282307924 0.215366972652938 no 2695 0.218538300057336 3840 6846614 SGTC_2872 9044037 25.97 µM -0.777746685795189 0.215176024902716 no 2696 0.218359181851108 3790 6465195 SGTC_2001 4023502 57.655 µM -0.779400186795409 0.214656716532574 no 2697 0.217872006919332 3826 108941 YCR052W RSC6 SGTC_322 k048-0136 19.3 µM -0.780040968789596 0.214455664721318 no 2698 0.217683380457542 3842 6823282 SGTC_927 2425-1185 123 µM -0.782443211850738 0.213702912093467 no 2699 0.216977073476782 3782 730375 SGTC_2260 7964312 200 µM -0.783160925070884 0.213478312698942 no 2700 0.216766308850892 3832 231951 SGTC_2325 6158266 200 µM -0.783234465454827 0.213455306926624 no 2701 0.2167447195719 3849 3623240 SGTC_3321 9137793 26.8275 µM -0.784087518497875 0.213188550404832 no 2702 0.216494379342665 3770 4904192 SGTC_1017 4239-0030 168 µM -0.785000120328064 0.212903387869844 no 2703 0.216226749022706 3856 1149593 SGTC_1657 st012939 43.4 µM -0.785692267399353 0.212687259796128 no 2704 0.216023897235349 3814 24207257 SGTC_3189 9110682 49.47 µM -0.786362703175947 0.212478033431495 no 2705 0.21582751365887 3894 17122418 SGTC_307 1501-1223 22.3 µM -0.786439488512252 0.212454078310508 no 2706 0.215805028357724 3813 2830329 SGTC_805 3852-0218 479 µM -0.787504587300165 0.21212195667007 no 2707 0.215493272059542 3746 6615355 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.78859038257401 0.211783694075401 no 2708 0.215175726914388 3842 6710655 SGTC_664 1222-0054 14.9 µM -0.788667988335815 0.211759529302011 no 2709 0.215153041205878 3771 6813991 SGTC_2137 5261020 140 µM -0.789219015435092 0.211587997661399 no 2710 0.214992004950653 3785 763655 SGTC_2312 7706453 155.7 µM -0.790236449214134 0.211271490084377 no 2711 0.214694846548224 3846 976098 SGTC_2912 7964298 10.93 µM -0.790523871785089 0.211182127734922 no 2712 0.21461094327954 3870 2975850 SGTC_2720 fluspirilene 36.88 µM -0.790745663152112 0.211113185879338 no 2713 0.214546211843974 3793 3396 An atypical antipsychotic. SGTC_2869 9037858 32.47 µM -0.792320278210245 0.210624110300909 no 2714 0.214086975347502 3762 27187042 SGTC_633 0437-0093 97.7 µM -0.792331728721846 0.210620556207462 no 2715 0.214083637902218 3779 2831118 SGTC_860 0443-0016 25.1 µM -0.794363881432523 0.209990359267532 no 2716 0.21349181230518 3845 5337942 SGTC_1519 esterone 74 µM -0.795117995761485 0.209756780795458 no 2717 0.213272433735801 3817 698 A steroid. SGTC_2181 6316240 54.2555 µM -0.797602275768609 0.208988384154399 no 2718 0.212550664982867 3843 12779990 SGTC_1966 st070145 16.1 µM -0.797745626168124 0.20894409601817 no 2719 0.212509060347849 3796 3748532 SGTC_89 0302-0250 142.109 µM -0.798228471919952 0.208794961399081 no 2720 0.212368958863768 3886 4203518 YLR208W SEC13 SGTC_2580 diallyl disulphide 81.36 µM -0.801322713197988 0.207840745520284 no 2721 0.211472422517651 3856 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3276 9139060 49.47 µM -0.802406749891515 0.207507055606804 no 2722 0.211158854920725 3899 4870619 SGTC_1676 st018489 23.4 µM -0.802924059887036 0.20734792808217 no 2723 0.211009314326981 3887 3696235 SGTC_2665 lovastatin 100 µM -0.804094892026529 0.206988039940332 no 2724 0.2106710871764 3859 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_757 1066-0008 322 µM -0.805284137724528 0.206622870534477 no 2725 0.210327866587683 3886 6842497 SGTC_1289 0976-0073 69.1 µM -0.805557615469322 0.206538950533794 no 2726 0.210248986381975 3903 3391136 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.809550439167607 0.20531600446843 no 2727 0.209099301192504 3872 229346 A bile salt which induces apoptosis. SGTC_1848 st056003 16.4 µM -0.81039536490742 0.205057768036248 no 2728 0.208856490487706 3882 146492 SGTC_1702 st027038 51 µM -0.811929736628224 0.204589308684609 no 2729 0.208415975105261 3875 5521182 SGTC_1323 1348-1351 11.2 µM -0.814494692301395 0.203807625026004 no 2730 0.207680805816809 3803 6989654 SGTC_2399 5884133 200 µM -0.814704348691048 0.203743809945484 no 2731 0.207620781772067 3868 722445 SGTC_3030 9087619 49.47 µM -0.81473983914626 0.203733008561995 no 2732 0.207610621967416 3893 25236973 SGTC_1721 st082152 9.2685 µM -0.815925984864937 0.203372206081033 no 2733 0.207271234642644 3795 5296051 SGTC_3158 9100007 49.47 µM -0.819407312648522 0.202315457615782 no 2734 0.206277032079063 3876 19297233 SGTC_2626 ethyl orsellinate 100 µM -0.820198924937532 0.202075624750799 no 2735 0.206051357370605 3876 75653 A natural product. SGTC_3000 9075062 71.4286 µM -0.821152506563707 0.201786946454506 no 2736 0.205779702563855 3841 17057871 SGTC_2822 7994718 71.43 µM -0.822028090095421 0.201522098164893 no 2737 0.205530454982593 3834 1018011 SGTC_2168 5727979 200 µM -0.822381631490844 0.201415217300191 no 2738 0.205429865105362 3786 695210 SGTC_3228 9131799 49.47 µM -0.822383493529438 0.201414654467957 no 2739 0.205429335394078 3871 17015818 SGTC_2455 5377712 9.75 µM -0.822500235652759 0.201379369095456 no 2740 0.205396126305714 3871 2243908 SGTC_2911 7942208 15.64 µM -0.822856663177127 0.201271661602228 no 2741 0.205294754756606 3894 1243384 SGTC_1243 0416-0003 5.65 µM -0.823273921610781 0.201145615735991 no 2742 0.20517612005926 3869 2141977 SGTC_885 0865-0106 16.8 µM -0.824224668931148 0.200858589855 no 2743 0.204905956288815 3797 2793380 SGTC_665 3914-0008 307 µM -0.82555095656826 0.200458601045561 no 2744 0.204529432752144 3826 1069549 SGTC_2882 9058044 58.44 µM -0.827560537831556 0.199853453369442 no 2745 0.203959712266493 3864 18076804 SGTC_1692 fluoroquinolonic acid 71 µM -0.829331316673425 0.199321128267521 no 2746 0.203458477367704 3914 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2817 7995342 71.43 µM -0.830318610116936 0.199024702777287 no 2747 0.203179334415811 3878 18879975 SGTC_628 1636-0253 16 µM -0.831086203075463 0.198794423918653 no 2748 0.202962466647377 3891 4456143 SGTC_2446 5162541 200 µM -0.832585319856883 0.19834515043635 no 2749 0.20253932056315 3834 1549321 SGTC_2247 cerulenin 830 nM -0.832895940270582 0.19825213663887 no 2750 0.202451709733269 3887 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1042 0350-0096 82 µM -0.833908926558204 0.197948985723111 no 2751 0.202166153317355 3882 3122515 SGTC_3035 9091303 49.47 µM -0.834480975338253 0.197777915556528 no 2752 0.202005001784192 3911 25237002 SGTC_912 3474-0017 2.18 µM -0.834675482964848 0.197719768755257 no 2753 0.201950224672897 3917 3360550 SGTC_2333 9017922 200 µM -0.834978941191531 0.19762907250873 no 2754 0.20186478272349 3932 3163164 SGTC_1233 0325-0408 14.2 µM -0.83569733308127 0.197414462987001 no 2755 0.201662597993134 3942 12874 SGTC_2619 obliquin 87.91 µM -0.836763179866627 0.197096315960116 no 2756 0.201362848891313 3839 6708593 A bioactive alkalod. YER133W GLC7 SGTC_852 0418-0143 439 µM -0.837385653227654 0.19691065607422 no 2757 0.201187913711116 3933 5369229 SGTC_476 mead acid 10 µM -0.837389373896904 0.196909546659961 no 2758 0.201186868356576 3894 5312531 An omega 9 fatty acid. SGTC_1003 4049-0218 100 µM -0.837695129035634 0.196818390750423 no 2759 0.201100974909934 3911 295161 SGTC_142 0335-0849 62.6745 µM -0.838116435547669 0.196692826954395 no 2760 0.200982656540129 3903 3889043 YPR107C YTH1 SGTC_2715 st079500 56.4 µM -0.83812198141412 0.196691174419527 no 2761 0.200981099335313 3826 28246688 SGTC_3011 9081274 71.4286 µM -0.838629584172859 0.196539956613415 no 2762 0.200838601949023 3886 6625322 SGTC_2079 5212404 121 µM -0.838922476611118 0.196452734315318 no 2763 0.200756406964238 3822 758462 SGTC_1695 st026914 34.495 µM -0.840473199772554 0.195991325636533 no 2764 0.200321560999473 3839 3289191 SGTC_3067 9117431 49.47 µM -0.841537839422743 0.195674929232251 no 2765 0.200023348005751 3936 17150885 SGTC_271 rotenone 740 µM -0.844052220080562 0.194928921435002 no 2766 0.199320112770388 3896 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2857 9024691 58.44 µM -0.845822786928147 0.194404639725567 no 2767 0.198825805779023 3981 16478292 SGTC_2185 6113692 200 µM -0.846240807180827 0.194280985322602 no 2768 0.198709210772576 3902 874150 SGTC_227 fluconazole 33.516 µM -0.846461504091245 0.194215720380991 no 2769 0.198647670202026 3894 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1415 3966-0071 78.1 µM -0.846577266095852 0.194181492343753 no 2770 0.198615394963373 3835 2893185 SGTC_444 curcumin 90.4 µM -0.847128252837989 0.194018629198489 no 2771 0.198461819446521 3862 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2071 5230951 39.92 µM -0.849049813537552 0.193451297189403 no 2772 0.197926787253649 3935 1799272 SGTC_1711 st032263 62.8 µM -0.852952278658453 0.192302231171692 no 2773 0.196842884338544 3907 3958979 SGTC_98 0074-0023 107.663 µM -0.853212008011238 0.192225903295267 no 2774 0.196770872751847 3887 3563821 SGTC_1287 0971-0001 34.6 µM -0.854095747426558 0.191966333503007 no 2775 0.196525969993603 3894 4665869 SGTC_544 k015-0020 52.4 µM -0.854499807882644 0.191847725347791 no 2776 0.196414057906214 3921 3008304 SGTC_97 0535-0701 19.132 µM -0.856504505348469 0.191259928949293 no 2777 0.195859390930214 3833 2832013 YGL099W LSG1 SGTC_3156 9099931 49.47 µM -0.856794711321643 0.191174929359125 no 2778 0.19577917451974 3936 18111053 SGTC_1995 st072814 61.1 µM -0.857053386425693 0.19109918449723 no 2779 0.195707690430057 3902 5769371 SGTC_1087 pterostilbene 9.05 µM -0.857243662637589 0.19104347984657 no 2780 0.195655118284194 3975 5281727 Similar to reservatol, lowers cholesterol. SGTC_2727 riluzole 51.77 µM -0.857782400009788 0.190885814850021 no 2781 0.195506314974276 3917 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2081 5214970 32.255 µM -0.859281192385336 0.190447603642446 no 2782 0.195092698977441 3824 2063512 SGTC_2355 9061122 103.12 µM -0.859892260079853 0.190269119412571 no 2783 0.194924217715452 3943 5302957 SGTC_24 0417-1663 219 µM -0.86013889396039 0.190197110261009 no 2784 0.19485624182829 3890 4329390 SGTC_2937 9044753 11.33 µM -0.861695031803446 0.189743154337382 no 2785 0.194427680127111 3889 6465530 YGL099W LSG1 SGTC_1269 0831-0796 3.05 µM -0.862283364983356 0.189571699746334 no 2786 0.194265802251945 3966 927758 SGTC_1847 st056231 15 µM -0.864083189233419 0.189047779304127 no 2787 0.193771096548279 3916 5393180 SGTC_1373 2887-0003 58.5 µM -0.86457389263564 0.188905092703939 no 2788 0.193636353525776 3912 776948 SGTC_1594 piperine 70.1 µM -0.867288799044571 0.188116852677554 no 2789 0.192891896147245 3905 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1911 st060208 74.3 µM -0.868951365716082 0.187635150378393 no 2790 0.192436866272946 3982 688783 SGTC_1304 1165-0502 251 µM -0.869266983899458 0.187543791160707 no 2791 0.192350558532231 3935 767425 SGTC_508 roscovitine 141 µM -0.870385203622762 0.187220331208595 no 2792 0.192044964996518 3984 160355 A CDKinase inhibitor. SGTC_1728 st035614 33.7865 µM -0.871691415065954 0.186842929285647 no 2793 0.191688372458601 3924 15945546 SGTC_2897 9048598 12.99 µM -0.87575508489681 0.185671832411437 no 2794 0.190581596098651 3918 6467404 SGTC_209 4077-0173 175.592 µM -0.876156713752584 0.185556335998361 no 2795 0.190472422363447 3906 15993494 SGTC_944 3370-0224 231 µM -0.877393782525296 0.185200872363493 no 2796 0.190136394527573 3982 4580514 SGTC_424 splitomicin 100 mM -0.878199259903481 0.18496965118111 no 2797 0.189917796793011 4043 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1033 k072-0102 21.3 µM -0.878832965366842 0.184787865155276 no 2798 0.189745924716213 3918 5965931 SGTC_2448 5185112 27.17 µM -0.878984441093005 0.184744428973955 no 2799 0.18970485600279 3970 5718189 SGTC_1926 methyl fluorone black 53.6 µM -0.879097560561571 0.184711995720556 no 2800 0.18967419015976 3713 72721 Reacts with homocysteine. SGTC_678 1218-2179 85.9 µM -0.881273784898958 0.184088724898102 no 2801 0.189084825733877 3918 6820081 YOR116C RPO31 SGTC_3019 9081971 49.47 µM -0.881370709479678 0.184060996178121 no 2802 0.189058602909978 3971 16451803 SGTC_2689 tacrolimus 100 µM -0.882214100080212 0.183819824097412 no 2803 0.188830519194626 3960 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.883305116024459 0.183508134369542 no 2804 0.188535720187276 3967 91467 include heat shock SGTC_341 1486-1430 230 µM -0.883530064029102 0.183443910498891 no 2805 0.188474973203442 3928 2054753 YPL210C SRP72 SGTC_619 1652-1634 108 µM -0.884271149038497 0.18323242585977 no 2806 0.188274929339558 3920 5400454 SGTC_1564 D-Arginine 115 µM -0.884434781673087 0.183185750249172 no 2807 0.188230777028772 3961 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3077 9117319 49.47 µM -0.88895501262957 0.181899304074212 no 2808 0.187013628984396 3914 17154678 SGTC_1301 naphtanilide LB 4.81 µM -0.889023570035558 0.18187983641029 no 2809 0.186995206315259 4023 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1446 4239-0190 62 µM -0.889912087929962 0.181627649430979 no 2810 0.186756546364663 3972 1340085 SGTC_1433 4060-0023 7.6 µM -0.890576561312574 0.181439195820193 no 2811 0.186578189071159 3961 3840627 SGTC_2223 6903751 107.57 µM -0.891858228315123 0.18107604369027 no 2812 0.18623446332645 3917 5598863 SGTC_3070 9117005 49.47 µM -0.89243446895328 0.180912918096756 no 2813 0.186080051341345 4005 8779016 SGTC_2314 7727897 200 µM -0.892806332256052 0.18080769775275 no 2814 0.185980447354047 3968 900724 SGTC_2132 5317594 122.667 µM -0.892934119519219 0.180771548647196 no 2815 0.18594622703057 3933 794577 SGTC_810 3825-7150 143 µM -0.893558120850168 0.180595093091225 no 2816 0.185779180959473 4028 22330411 YGL099W LSG1 SGTC_2732 terfenadine 20 µM -0.89434044217151 0.180374020354478 no 2817 0.185569883946943 3962 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_95 0471-0001 561.058 µM -0.894399939166904 0.180357214311109 no 2818 0.18555397250831 3957 4015405 SGTC_2033 5192550 145 µM -0.895787542938261 0.179965538270551 no 2819 0.185183122132632 3946 182073 SGTC_2086 5274770 176.623 µM -0.896343137783194 0.179808861529296 no 2820 0.185034763245773 4028 689278 SGTC_930 2810-3379 265 µM -0.896473298012264 0.179772168971723 no 2821 0.185000017614584 4013 1015764 SGTC_2677 mitomycin C 100 µM -0.899294075135069 0.178978139324594 no 2822 0.184248021207093 3981 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1235 benzylparaben 21.5 µM -0.900918348128879 0.178521920322584 no 2823 0.183815867444842 3982 7180 SGTC_2698 st077697 67.5 µM -0.901383448600284 0.178391419864934 no 2824 0.183692239273309 3949 3154499 SGTC_2017 5132927 60.65 µM -0.902994930525832 0.177939726414288 no 2825 0.183264292740234 3994 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1925 st057770 10.1 µM -0.906865329883448 0.176857814848823 no 2826 0.182239008605924 3960 5989122 SGTC_1471 k673-0312 37 µM -0.90705241552295 0.176805623450324 no 2827 0.182189539876288 3923 24099884 SGTC_3247 9135149 49.47 µM -0.907659063720826 0.176636453398318 no 2828 0.182029189176084 3958 8934436 YOR116C RPO31 SGTC_1612 st002233 45.4 µM -0.910065869510933 0.175966300006804 no 2829 0.181393886409986 3977 1035021 SGTC_594 1487-1584 10.8 µM -0.910068906848591 0.175965455305945 no 2830 0.181393085549481 3945 5013332 SGTC_1067 clotrimazole 1.36 µM -0.910188824364675 0.175932107615245 no 2831 0.181361468442598 3993 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1104 tacrolimus 29.8 µM -0.911155063571212 0.175663553589977 no 2832 0.18110683852314 4009 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_171 k064-0041 9.68 µM -0.913228201653403 0.17508822799919 no 2833 0.180561267295718 4001 53325 SGTC_463 ikarugamyin 104 µM -0.914229984532538 0.17481064771128 no 2834 0.180298005856791 4055 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1437 4092-1038 11.6 µM -0.915520140085648 0.174453575062128 no 2835 0.179959317176043 4016 3977136 SGTC_2178 5812956 200 µM -0.916563737676783 0.174165080743505 no 2836 0.179685646823924 3946 5403383 SGTC_804 1595-0054 20.9 µM -0.917121139498438 0.174011115709576 no 2837 0.179539582394863 3932 761523 Stimulates phospholipase C. SGTC_1515 3460-0031 42.1 µM -0.922177516563335 0.17261840268677 no 2838 0.178217994332566 3915 2876596 SGTC_78 0336-0123 156.75 µM -0.922520278937926 0.172524251181686 no 2839 0.178128628793115 3819 6765896 SGTC_1870 st057514 26.5 µM -0.924630040969529 0.171945453634155 no 2840 0.177579190571837 3979 5393161 SGTC_1993 st073995 70.8 µM -0.925625006480392 0.171672922945269 no 2841 0.177320446594742 3989 3098394 SGTC_624 k048-0052 28 µM -0.925711286984218 0.171649302888783 no 2842 0.177298020294934 3978 6835531 SGTC_1428 4049-0204 61.7 µM -0.926256582632625 0.171500071375644 no 2843 0.177156326768168 4062 X1428 SGTC_1043 0916-0009 19.3 µM -0.927990386583955 0.171026130918357 no 2844 0.176706278175437 4047 3101130 SGTC_516 3992-2719 87.3 µM -0.929993301402389 0.170479672198968 no 2845 0.176187276387271 3947 5350887 YDR037W KRS1 SGTC_392 N-ethylmaleimide 8.33 µM -0.930625614357174 0.170307389628201 no 2846 0.176023629975569 3951 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3298 9116858 71.43 µM -0.931647448883639 0.170029212261932 no 2847 0.175759376523867 4073 2506942 SGTC_543 3844-1095 191 µM -0.93458676133416 0.169230658397587 no 2848 0.175000652105017 4018 4230703 SGTC_3051 9093778 49.47 µM -0.935653012772244 0.168941574793028 no 2849 0.17472593515174 4044 17217378 SGTC_256 clotrimazole 625 nM -0.935853297059502 0.168887308842767 no 2850 0.174674362977059 3935 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1723 st034307 2.5525 µM -0.936217497453368 0.168788659404929 no 2851 0.174580608015908 4068 867466 SGTC_2210 7115885 190.385 µM -0.937136396626029 0.168539925629636 no 2852 0.174344200751806 4069 2927039 SGTC_1250 0485-0349 40.2 µM -0.937140443004296 0.168538830850289 no 2853 0.174343160180928 4020 6842794 YDL195W SEC31 SGTC_1147 3809-1045 12.3 µM -0.937890275912391 0.168336036605549 no 2854 0.174150400481618 3986 325925 SGTC_7 0192-1582 4.227 µM -0.937940094504768 0.168322568600882 no 2855 0.174137598406521 4048 252616 SGTC_2131 toluylene red 5.2905 µM -0.938144284596687 0.168267374903084 no 2856 0.17408513314449 4010 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_681 1642-0006 26.6 µM -0.941035379451071 0.167487145751957 no 2857 0.17334336445786 4045 4446530 SGTC_1358 1509-0022 2.48 µM -0.942376578828764 0.167125984653554 no 2858 0.172999936989956 4044 3258434 SGTC_1366 1683-0113 21.9 µM -0.943315978779873 0.166873320218832 no 2859 0.172759652587614 4022 708623 SGTC_1293 1000-1278 195 µM -0.943639273599552 0.166786422687498 no 2860 0.172677007853257 4079 678847 SGTC_2589 lobaric acid 100 µM -0.943743372235835 0.166758448514297 no 2861 0.172650402200956 4032 73157 A novel microtubule depolymerizer. SGTC_2327 6189656 200 µM -0.946902878923867 0.165910842463158 no 2862 0.171844135405321 4118 5349088 SGTC_2833 9001315 45.46 µM -0.948989160107273 0.165352681459546 no 2863 0.171313062642089 4004 2989378 SGTC_3268 9137683 49.47 µM -0.949580157879576 0.165194787765384 no 2864 0.171162812272764 4061 1953228 SGTC_1815 st051655 58.2 µM -0.949769570049132 0.165144204191863 no 2865 0.17111467553209 3980 5984156 SGTC_2569 tetrandrine 100 µM -0.950193172771608 0.165031115016575 no 2866 0.17100705351961 4043 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_722 3534-0461 190 µM -0.950859075996721 0.164853440288861 no 2867 0.170837959335724 4084 658262 SGTC_527 4476-4215 268 µM -0.951361559080476 0.164719450985394 no 2868 0.170710433621695 4014 4418754 SGTC_2265 7929201 200 µM -0.952157937786995 0.164507237696367 no 2869 0.170508444672368 4000 1265108 SGTC_1429 4049-0205 9.46 µM -0.95241432218735 0.164438955942339 no 2870 0.17044344937546 4058 22774478 SGTC_1785 bathophenanthroline 24 µM -0.952791162924253 0.164338626921831 no 2871 0.170347946331268 3962 72812 An iron chelator. SGTC_211 3455-0679 143.504 µM -0.952827770303497 0.164328882791281 no 2872 0.170338670721349 4081 748649 SGTC_2098 5376439 882.5 nM -0.953079360415833 0.164261924818231 no 2873 0.17027493135023 4073 2844116 SGTC_762 1165-0429 115 µM -0.954001882804996 0.164016556905726 no 2874 0.170041344665095 4043 5967793 SGTC_3222 9128301 49.47 µM -0.954295938812267 0.163938395355718 no 2875 0.169966931591662 4046 4911358 SGTC_118 0083-0097 135.343 µM -0.954561566122225 0.163867811075158 no 2876 0.169899730561264 4061 5207356 SGTC_573 3702-0553 84.7 µM -0.955075434015827 0.163731318621861 no 2877 0.169769775527322 3978 1222756 SGTC_3323 9138564 53.9225 µM -0.959118293184903 0.162660038533325 no 2878 0.168749577897522 4070 43912313 YNL103W MET4 SGTC_144 4161-2749 112.381 µM -0.960296860964742 0.162348600990997 no 2879 0.168452914729782 3965 797501 YMR168C CEP3 SGTC_3229 9132204 49.47 µM -0.960546979843183 0.162282556823314 no 2880 0.168389999223719 4095 17682924 SGTC_3348 9149464 3.537 µM -0.962021303266384 0.1618936155452 no 2881 0.168019451469792 4007 1951442 SGTC_972 1319-0219 195 µM -0.962912457356979 0.161658814909961 no 2882 0.167795728717962 4027 23903702 SGTC_1978 st071761 42 µM -0.963428936005305 0.161522835140708 no 2883 0.16766615544713 4068 5147680 SGTC_2655 perillic acid 100 µM -0.963599139647938 0.161478039848816 no 2884 0.167623469172379 4073 5702197 An apoptosis inducer. SGTC_1131 3454-3128 32.3 µM -0.965943794132192 0.160861783048179 no 2885 0.167036153300203 4099 710982 SGTC_1857 st056007 79.3 µM -0.966822091866458 0.160631331653232 no 2886 0.166816489299436 4041 619834 SGTC_2680 butyl paraben 22.24 µM -0.970985909906181 0.159541747615082 no 2887 0.165777647547502 4116 7184 An antifungal and steroid mimetic. SGTC_44 0929-0055 61.211 µM -0.972694634915971 0.159096013269701 no 2888 0.165352546259355 3969 1379590 SGTC_1469 k284-2957 126 µM -0.973014325456506 0.159012710162793 no 2889 0.165273091164791 4036 23884841 SGTC_1696 st025591 34.7925 µM -0.973864531881954 0.158791307398309 no 2890 0.165061903218432 4060 2787147 SGTC_237 nikkomycin 200 µM -0.974599085317779 0.158600184687616 no 2891 0.164879583762377 4079 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1288 0973-0013 65.5 µM -0.977007451017722 0.157974612977555 no 2892 0.164282731802162 4104 4315430 SGTC_878 0828-0289 13.7 µM -0.978423101202335 0.157607655623619 no 2893 0.163932553632367 4019 745350 YLR208W SEC13 SGTC_3099 9120367 49.47 µM -0.978721990165043 0.157530250869645 no 2894 0.163858681807479 4084 24824940 SGTC_1488 4013-0813 75.9 µM -0.979696686702647 0.157278002474039 no 2895 0.163617931054094 4000 2910057 SGTC_668 1682-0499 62.6 µM -0.980472678639124 0.157077368176724 no 2896 0.163426424774022 4051 682214 SGTC_2903 5923464 63.88 µM -0.980529359002823 0.157062719952904 no 2897 0.163412442391102 4081 2876576 SGTC_1385 3091-4834 14.1 µM -0.980985248927579 0.156944934442856 no 2898 0.163300007938408 4041 4072814 SGTC_2558 carylophyllene oxide 100 µM -0.981321707343854 0.156858043005159 no 2899 0.163217060680656 4178 6708694 An oxygenated terpenoid and antifungal agent. SGTC_296 1222-0039 74.9 µM -0.982252026830807 0.15661794988574 no 2900 0.162987851096235 4066 5984176 SGTC_2607 solasodine 47.35 µM -0.982316162634713 0.156601406893474 no 2901 0.162972057205283 4055 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1782 st039423 80.636 µM -0.982970171031603 0.156432779651611 no 2902 0.162811059862535 4097 2068169 SGTC_3290 9121031 71.43 µM -0.983007900786502 0.1564230551928 no 2903 0.162801775079918 4087 17014854 SGTC_2195 6536160 144.242 µM -0.98426431293503 0.156099455158644 no 2904 0.162492785700271 4021 3834386 SGTC_1571 st070080 73.4 µM -0.985734514005004 0.15572135242051 no 2905 0.16213170409197 4112 4315245 SGTC_1165 k072-0275 30.3 µM -0.989568601554354 0.154738154612008 no 2906 0.161192511641953 4045 6153523 YGL055W OLE1 SGTC_1852 st056254 31.4 µM -0.990452356078966 0.154512111124317 no 2907 0.160976532804301 3997 442583 SGTC_3333 9141820 12.094 µM -0.991265356383363 0.154304357741918 no 2908 0.160778012315336 4069 1939433 SGTC_335 4077-0256 27.6 µM -0.992857475034342 0.153898044452431 no 2909 0.160389707968194 4069 3121989 SGTC_1389 3405-0187 19 µM -0.992967074284125 0.153870100478513 no 2910 0.160363000196342 4048 799890 SGTC_2895 9054447 58.44 µM -0.993233505905849 0.153802183741937 no 2911 0.160298086735872 4137 2697450 SGTC_1909 st060837 51.5 µM -0.994596602869202 0.153455023847581 no 2912 0.159966250206247 4071 678937 SGTC_2513 baicalein 25.65 µM -0.994666627800111 0.153437203598972 no 2913 0.159949215262035 4094 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_574 1315-0397 40 µM -0.994711173912042 0.153425868024276 no 2914 0.159938379160029 4058 6794277 SGTC_1436 4092-1007 8.32 µM -0.996629878190502 0.152938145059066 no 2915 0.159472098862807 4078 2881121 SGTC_948 3448-0295 75.3 µM -0.996655354546414 0.15293167604703 no 2916 0.159465913633887 4065 678569 SGTC_2111 5486399 200 µM -0.997700875928679 0.15266635146726 no 2917 0.159212214173367 4054 689674 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.998733177017568 0.152404681601547 no 2918 0.158961982168507 4076 2346 DNA damaging agent; causes G2/M arrest. SGTC_979 1426-2828 121 µM -1.0003689256338 0.15199065846706 no 2919 0.158566001195402 4189 747872 SGTC_3353 9151644 39.2805 µM -1.00438913123038 0.150976284314489 no 2920 0.157595543379396 4134 4909158 SGTC_3248 9135562 49.47 µM -1.00487383132083 0.150854290344781 no 2921 0.157478803338537 4075 17650701 SGTC_1610 st001799 48.1 µM -1.0070353955815 0.150311046139039 no 2922 0.156958882503181 4005 621897 SGTC_1937 st074714 47.2 µM -1.00712052785728 0.150289677416377 no 2923 0.156938428784901 4057 17250970 SGTC_47 0149-0135 24.25 µM -1.00906176064241 0.149802965490058 no 2924 0.156472507781907 4132 5239155 SGTC_2489 cantharidin 73.42 µM -1.01081985885065 0.149363077897863 no 2925 0.156051328247596 4056 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2464 5717415 7.67 µM -1.01082818471229 0.149360996766849 no 2926 0.156049335438209 4092 5285744 SGTC_2996 9066192 71.4286 µM -1.01168056126176 0.149148039300593 no 2927 0.155845406385461 4146 6472854 SGTC_1951 sophoraflavanone G 9.2 µM -1.01185564892742 0.149104320575725 no 2928 0.15580353884179 4072 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_348 k064-0012 10.7 µM -1.0129267826421 0.148837048925217 no 2929 0.155547567269121 4005 5066323 SGTC_3325 9138760 55.175 µM -1.01352593524853 0.148687686756904 no 2930 0.155404507290349 4037 43844959 SGTC_2416 tofa 880 nM -1.01863523695775 0.147418064926099 no 2931 0.154188084556142 4123 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2734 clemastine 41.6 µM -1.02108232902493 0.1468125618562 no 2932 0.15360771724659 4144 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2651 TUB2.036 5 µM -1.02191234323093 0.146607564427215 no 2933 0.153411194952562 4085 15992207 YFL037W TUB2 SGTC_273 hydroxyurea 18.1 mM -1.02592023386993 0.145620397337463 no 2934 0.152464592154924 4188 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1063 disulfiram 1.84 µM -1.02656633450811 0.145461678228667 no 2935 0.1523123565875 4122 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2364 9055074 200 µM -1.02757424463946 0.14521431051339 no 2936 0.152075072271311 4141 6470630 SGTC_448 monastrol 171 µM -1.02868455407792 0.144942139146467 no 2937 0.151813965223617 4033 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1899 st063254 59.6 µM -1.03001929188053 0.144615408257419 no 2938 0.151500474763441 4068 3093813 SGTC_547 1120-0019 610 nM -1.03289541962908 0.143913047625759 no 2939 0.150826421261744 4081 3676939 SGTC_3274 9138298 49.47 µM -1.0339690673918 0.143651449798448 no 2940 0.150575312132452 4082 17015756 SGTC_2867 9039098 71.43 µM -1.03442192975985 0.143541204673052 no 2941 0.150469478372702 4074 6463460 SGTC_3204 9114183 49.47 µM -1.035231520339 0.143344259732042 no 2942 0.150280400878107 4106 17027248 SGTC_1051 3253-3903 78 µM -1.03536048006027 0.143312905218795 no 2943 0.150250297340893 4109 5509239 SGTC_781 4335-2806 94.4 µM -1.03640466793217 0.143059198058742 no 2944 0.150006696783804 4194 845254 SGTC_1873 rapamycin 2 nM -1.03711892626788 0.142885829021526 no 2945 0.149840217868258 4079 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2656 pseudo-anisatin 100 µM -1.03727941843275 0.142846892953319 no 2946 0.149802827410576 4158 6708809 A neurotoxin. SGTC_62 0180-0423 3.232 µM -1.04019557199368 0.142140670844004 no 2947 0.149124524162809 4094 30102 YGL099W LSG1 SGTC_1122 capsaicin 818.572 nM -1.04099427966254 0.141947656038906 no 2948 0.148939101556796 4198 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1844 rapamycin 4 nM -1.04587693322154 0.140771578484429 no 2949 0.147808927722293 4043 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2189 6047310 154.431 µM -1.0497515005666 0.139843035055719 no 2950 0.146916189410393 4127 711535 SGTC_3254 9136651 49.47 µM -1.05058066205226 0.139644867805972 no 2951 0.146725613231762 4110 16454030 SGTC_787 4152-0075 138 µM -1.05149966743402 0.139425451321733 no 2952 0.14651458103039 4158 9566539 SGTC_2735 sertaconazole 140 nM -1.05421168181995 0.138779313986802 no 2953 0.145893006441629 4280 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1229 0139-0193 12.2 µM -1.05442875013734 0.138727685759042 no 2954 0.145843332621379 4233 3090752 SGTC_3079 9117512 49.47 µM -1.05479366031265 0.138640923832502 no 2955 0.145759852352878 4203 7185044 SGTC_2040 5100729 123 µM -1.05598362016324 0.138358252952624 no 2956 0.145487849180582 4172 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1663 st014140 55.4 µM -1.05716267506044 0.138078560202923 no 2957 0.14521867557984 4218 4207120 SGTC_3057 9095946 49.47 µM -1.05822854806438 0.137826048259715 no 2958 0.144975629529387 4186 24540043 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.05973190984226 0.137470428383127 no 2959 0.144633290698496 4159 16486 A toxic proline analog. SGTC_2117 5521686 200 µM -1.05973618043123 0.137469419069431 no 2960 0.144632318995332 4097 803312 SGTC_3092 9117248 49.47 µM -1.06000812473665 0.137405157998969 no 2961 0.144570451541007 4262 17141857 SGTC_2280 7785178 200 µM -1.06248342901409 0.136821180895845 no 2962 0.144008138443716 4142 2954328 SGTC_1545 lovastatin 49.4 µM -1.0639475042667 0.136476573909578 no 2963 0.143676240670517 4205 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_215 1287-0124 461.5 µM -1.06450340595493 0.136345884079682 no 2964 0.143550356145613 4179 5560863 SGTC_1683 st010134 710 nM -1.06552272668749 0.136106469144989 no 2965 0.143319723355417 4145 3818134 SGTC_1775 st081588 35.1725 µM -1.07157366261447 0.134691169070604 no 2966 0.141955784106217 4163 1426443 YGL099W LSG1 SGTC_2381 9035592 200 µM -1.07170917153255 0.134659589893524 no 2967 0.141925340035362 4152 4749657 SGTC_3134 9127454 49.47 µM -1.07431316055503 0.134053739753066 no 2968 0.141341174253256 4214 24262820 SGTC_2047 4141938 200 µM -1.07471584572204 0.133960217547377 no 2969 0.141250983600614 4162 3807862 SGTC_2343 7990716 14.84 µM -1.07532768808589 0.133818205155019 no 2970 0.141114022048698 4163 6456862 SGTC_1689 st020265 53.493 µM -1.07865798811978 0.133047036723194 no 2971 0.140370110283071 4177 5758320 YPR016C TIF6 SGTC_2560 caryophyllene 100 µM -1.08319091115535 0.132002311294748 no 2972 0.139361846554241 4218 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1863 st057641 20.1 µM -1.08325462473038 0.131987667341574 no 2973 0.139347709867242 4200 3921635 SGTC_819 1013-0258 27.7 µM -1.0851281234527 0.131557562465821 no 2974 0.138932456457031 4176 5753198 SGTC_1747 st037496 66.6 µM -1.08537564585511 0.131500810416017 no 2975 0.138877657194665 4151 723305 SGTC_752 1896-0090 130 µM -1.08844615936465 0.130798206664897 no 2976 0.138199096468092 4171 772567 SGTC_421 streptovitacin 30 mM -1.08880583264529 0.130716075277432 no 2977 0.13811975949575 4239 91467 include heat shock SGTC_2100 5377183 190 µM -1.09117444196415 0.130176093860734 no 2978 0.137598065846034 4198 2844202 SGTC_2939 9044578 71.43 µM -1.09204142367596 0.129978830976771 no 2979 0.137407447085309 4112 2653634 SGTC_3256 9138902 49.47 µM -1.09312949730689 0.129731556354678 no 2980 0.137168473247016 4269 17228773 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.09559973046747 0.129171383363334 no 2981 0.136626989860685 4107 5355888 SGTC_2294 7971431 200 µM -1.0960109196485 0.129078301325367 no 2982 0.136536997911207 4183 5741572 SGTC_2714 st079313 56.9 µM -1.09706319468755 0.128840306733666 no 2983 0.136306883984373 4170 2939799 SGTC_3138 9097216 49.47 µM -1.09720853912075 0.128807457910514 no 2984 0.1362751205985 4143 25237486 SGTC_2242 6630449 61.2675 µM -1.09887257585676 0.128431788378114 no 2985 0.135911825061098 4245 691249 YDR170C SEC7 SGTC_2357 9067248 200 µM -1.09898564001679 0.12840629086763 no 2986 0.135887164769553 4163 9150235 SGTC_177 1327-0068 8.361 µM -1.1006908880093 0.128022160326572 no 2987 0.135515606679561 4199 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_484 loperamide 105 µM -1.10110817057495 0.127928283396595 no 2988 0.135424790706099 4203 3955 An opioid-receptor agonist. SGTC_777 1315-0167 517 µM -1.10385453955454 0.127311620376502 no 2989 0.134828120875684 4227 4221767 SGTC_2302 7771753 200 µM -1.10481663797658 0.127096082986222 no 2990 0.134619524809503 4209 2203047 SGTC_579 4491-1009 110 µM -1.10511317792938 0.127029700832773 no 2991 0.134555275581953 4313 1271041 SGTC_34 0469-0683 81.75 µM -1.10579858186875 0.126876361617446 no 2992 0.134406854485961 4158 3690923 SGTC_3053 9095903 49.47 µM -1.10616355896548 0.126794761194977 no 2993 0.134327866243886 4299 17174018 SGTC_850 0388-0143 75.9 µM -1.1062279393224 0.126780371030935 no 2994 0.134313936373 4175 67273 SGTC_379 3970-0972 5.9 µM -1.10670358348637 0.126674091266813 no 2995 0.134211052773389 4191 2898042 YBL034C STU1 SGTC_456 gingerol 170 µM -1.10819580110112 0.126341067143651 no 2996 0.13388863191627 4242 442793 A herb. SGTC_684 1140-0066 328 µM -1.10877157358617 0.126212732974295 no 2997 0.133764368204045 4239 6813534 SGTC_1934 st074720 32.6 µM -1.11015688059471 0.12590433368802 no 2998 0.133465714981189 4142 17250992 SGTC_2326 6164455 177.58 µM -1.11185519775326 0.125526969137733 no 2999 0.13310020725471 4166 2888790 SGTC_1473 k844-0725 134 µM -1.11326855181617 0.125213525457368 no 3000 0.132796554300718 4251 54682906 SGTC_1021 4476-0760 85.3 µM -1.11413795988136 0.125020985983856 no 3001 0.132610002939103 4207 746768 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.11641869783686 0.124516875956856 no 3002 0.132121476800221 4189 688667 SGTC_3273 9137859 49.47 µM -1.11669197636681 0.124456568857063 no 3003 0.132063024847927 4294 2377234 SGTC_3088 9117578 49.47 µM -1.11931725581218 0.123878262628863 no 3004 0.131502408386351 4254 678341 SGTC_2153 5569715 200 µM -1.11937286809877 0.123866032527048 no 3005 0.131490550431455 4249 2054701 SGTC_1416 3966-0321 25.3 µM -1.12371504413899 0.122913721166271 no 3006 0.130566966074952 4260 582530 YLR208W SEC13 SGTC_840 0245-0196 390 µM -1.12541912688767 0.122541393809655 no 3007 0.130205734873147 4298 3827528 SGTC_1457 k015-0032 57.3 µM -1.12627526821666 0.122354633281265 no 3008 0.130024511389606 4211 4302660 SGTC_376 3970-0862 59.1 µM -1.13006655112612 0.12152999608101 no 3009 0.129224091406512 4259 3135186 SGTC_1474 0330-0125 5.35 µM -1.13036634634349 0.121464955072017 no 3010 0.129160944333994 4242 X1474 SGTC_149 3970-0822 46.1 µM -1.13049899457792 0.12143618465477 no 3011 0.129133010930618 4221 3114250 YBL034C STU1 SGTC_2290 7904846 200 µM -1.1363780072253 0.120165879207999 no 3012 0.127899198034858 4277 2962154 SGTC_2635 hydroquinidine 100 µM -1.13718520452814 0.119992198118095 no 3013 0.127730435367518 4143 442912 An experimental heart treatment. SGTC_1949 st076024 69.1 µM -1.1397448876058 0.119442612814884 no 3014 0.127196300189599 4154 2921930 SGTC_2256 7954252 200 µM -1.13983890626494 0.119422460095396 no 3015 0.127176710724109 4244 2972920 SGTC_157 1348-1695 65.819 µM -1.14094418263398 0.11918572609463 no 3016 0.126946575806516 4171 5380510 SGTC_1166 k206-0078 225 µM -1.14111568888672 0.119149021677968 no 3017 0.126910891659281 4251 5404595 SGTC_2964 9083345 53.42 µM -1.14156568698391 0.119052754568278 no 3018 0.126817296792428 4221 17741579 SGTC_2457 5731572 11.68 µM -1.14156822264051 0.119052212276442 no 3019 0.126816769538745 4279 2865357 SGTC_661 1304-0007 33.6 µM -1.14515945264827 0.118285918392304 no 3020 0.126071555674971 4233 3117130 SGTC_1539 benzyladenosine 56 µM -1.14766450252024 0.117753461623863 no 3021 0.125553545305636 4227 92208 A nucleotide analog. SGTC_2417 cerulenin 830 nM -1.14827840350048 0.117623234084979 no 3022 0.12542682581753 4254 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1378 2093-0007 380 nM -1.14828317873268 0.117622221509085 no 3023 0.125425840479304 4295 3618014 SGTC_1259 0671-0132 43 µM -1.15062883495625 0.117125576768614 no 3024 0.124942482534461 4173 X1259 SGTC_3212 9128307 49.47 µM -1.15288668054104 0.116648929204393 no 3025 0.12447844987968 4162 27243542 SGTC_202 3594-0513 34.79 µM -1.15338505245435 0.116543904850577 no 3026 0.124376186982673 4292 708429 SGTC_727 3032-0951 202 µM -1.15562550625301 0.116072591493371 no 3027 0.123917185229588 4283 3652836 SGTC_1144 3486-0183 12.5 µM -1.1565144648995 0.115885961001007 no 3028 0.123735393208997 4240 6744069 SGTC_1342 1486-1464 234 µM -1.15652685350029 0.115883361609382 no 3029 0.123732861060355 4269 3253938 SGTC_1163 k060-0048 49.9 µM -1.15696498225709 0.115791459509812 no 3030 0.123643333748177 4240 6809982 SGTC_2138 5575593 77.673 µM -1.15784999317572 0.115605977095406 no 3031 0.123462628830119 4248 762213 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.16410865234312 0.114300297354172 no 3032 0.122189991338178 4307 23665772 A membrane-active detergent. SGTC_2765 myclobutanil 7.74 µM -1.16504136782833 0.114106617130769 no 3033 0.122001124121516 4285 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1286 0929-0070 131 µM -1.16604153593479 0.113899190102697 no 3034 0.121798826211091 4325 1420408 SGTC_1294 1000-1494 117 µM -1.1663786568965 0.113829334439674 no 3035 0.121730691943839 4243 712797 YDL207W GLE1 SGTC_3239 9133757 49.47 µM -1.17354496651244 0.112351603379048 no 3036 0.120288667832113 4297 17036923 SGTC_3304 9125678 46.087 µM -1.17555293839755 0.111940018347459 no 3037 0.11988678548015 4194 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2795 7780010 54.55 µM -1.17996055846103 0.111040347623376 no 3038 0.119007951105195 4237 953673 SGTC_329 k048-0121 21.3 µM -1.18201357361589 0.110623064560029 no 3039 0.118600157527299 4282 6832902 SGTC_2244 6635614 200 µM -1.18373939618822 0.110273155095596 no 3040 0.118258119406081 4188 836499 SGTC_2673 kobusone 100 µM -1.18440925567155 0.110137555556247 no 3041 0.118125549057972 4356 6710676 An epoxy ketone and protein crosslinker. SGTC_1575 cyproterone acetate 48 µM -1.18502061280606 0.110013903072247 no 3042 0.118004648541199 4285 9880 An androgen receptor antagonist and liver toxin. SGTC_2356 9061756 188.97 µM -1.18507340985214 0.110003229068746 no 3043 0.117994211631832 4303 20104043 SGTC_999 SEC7.066 22.7 µM -1.18962317025304 0.109086191185734 no 3044 0.117097267397791 4228 740511 YDR170C SEC7 SGTC_1964 st076914 61 µM -1.19489836569829 0.10802982993434 no 3045 0.116063370751373 4330 24208661 SGTC_1628 st004252 77.7 µM -1.19542853999796 0.107924070920825 no 3046 0.115959820247679 4303 692968 SGTC_93 0109-0045 59.227 µM -1.19607094688227 0.107796023717614 no 3047 0.115834437050074 4406 88733 SGTC_1159 4092-0538 61.2 µM -1.19697132467429 0.107616740908615 no 3048 0.115658865875932 4316 717301 SGTC_769 0302-0231 76 µM -1.20094213886611 0.106828637301863 no 3049 0.114886823398845 4189 571869 YER009W NTF2 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.20235636079437 0.106548959089225 no 3050 0.114612744551559 4320 4620898 SGTC_3220 9131269 49.47 µM -1.20489649153086 0.106047947842467 no 3051 0.114121631607343 4317 17722206 SGTC_3227 9130768 49.47 µM -1.20514348890319 0.105999321440341 no 3052 0.114073956825393 4345 17720899 SGTC_814 3342-0569 96 µM -1.20542020229407 0.105944863980092 no 3053 0.114020563188204 4344 4346283 SGTC_1440 4100-1550 40 µM -1.2054621509943 0.105936610200885 no 3054 0.114012470469756 4282 742806 SGTC_2883 9059145 45.46 µM -1.20877524002305 0.105286197458983 no 3055 0.113374603227259 4283 16476510 SGTC_303 1348-1668 34.2 µM -1.21127467618047 0.104797433359976 no 3056 0.112895075443234 4305 5380509 SGTC_3355 9151058 44.0485 µM -1.21152730394983 0.104748123640431 no 3057 0.112846688383036 4307 17015728 SGTC_306 1672-3436 11.6 µM -1.21539008587445 0.103996249480211 no 3058 0.11210867373909 4325 6797378 SGTC_1681 tripelennamine 100 µM -1.21775381459817 0.103538094081358 no 3059 0.111658770046965 4236 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1193 1488-0126 41.5 µM -1.21920899570157 0.103256769569948 no 3060 0.111382439251107 4268 1384710 SGTC_1789 tunicamycin 25 nM -1.21962577021301 0.103176298509416 no 3061 0.111303386336849 4197 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2177 5811945 192 µM -1.22029585067394 0.103047014479575 no 3062 0.111176371096432 4336 5343475 SGTC_1770 st043884 66.3 µM -1.22087277921262 0.102935797303345 no 3063 0.111067096183091 4310 670149 SGTC_293 4049-0273 38.5 µM -1.23063156986375 0.101067746318545 no 3064 0.109230346105117 4183 1380311 SGTC_2596 sinensetin 100 µM -1.2308068741505 0.101034416579928 no 3065 0.109197551966091 4327 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2051 5263410 176 µM -1.2311814447649 0.100963228167548 no 3066 0.109127504822084 4276 227584 SGTC_531 3788-1495 174 µM -1.23250653099258 0.100711684540989 no 3067 0.108879964245787 4291 2896655 SGTC_1396 3511-0007 98.6 µM -1.23436960647902 0.100358786947993 no 3068 0.108532604596654 4339 X1396 SGTC_2072 5231554 129 µM -1.23681771199325 0.099896448027186 no 3069 0.108077382466543 4355 789545 SGTC_3294 9122953 26.2835 µM -1.23690949729892 0.0998791441460782 no 3070 0.108060341880813 4289 16459826 SGTC_250 brefeldin a 552.239 µM -1.23690967212588 0.0998791111888079 no 3071 0.108060309424808 4205 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2005 4024620 188 µM -1.23792668419977 0.0996875249107223 no 3072 0.107871623495353 4280 236743 SGTC_1724 st037281 8.293 µM -1.23878217450289 0.0995265743890041 no 3073 0.107713088494385 4284 574124 YDL195W SEC31 SGTC_1667 st014849 34.6 µM -1.23916484476902 0.0994546409504102 no 3074 0.107642228396155 4387 5348460 SGTC_965 1291-5240 308 µM -1.24002252501584 0.0992935543254373 no 3075 0.10748353141758 4318 2834598 SGTC_1664 st014217 9.02 µM -1.24324232181089 0.098690525193285 no 3076 0.106889275720768 4375 3982782 SGTC_2733 amorolfine 100 µM -1.24364242702651 0.0986157779507476 no 3077 0.106815596961469 4478 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3022 9087993 49.47 µM -1.24438231283368 0.0984776624381295 no 3078 0.10667944468345 4388 17173644 SGTC_2683 piperine 63.03 µM -1.24460252743738 0.0984365820348713 no 3079 0.106638945439004 4322 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2141 5621638 7.665 µM -1.24516617597685 0.0983314921798485 no 3080 0.106535336475146 4344 2856238 SGTC_214 4373-3496 70 µM -1.2457234587486 0.0982276699978166 no 3081 0.106432969120684 4420 3779166 SGTC_1120 ficusin 1.78878 µM -1.24598106983037 0.0981797040149267 no 3082 0.106385672514186 4347 6199 A DNA cross-linker. SGTC_1195 1502-0147 41.1 µM -1.24821910574621 0.0977637140374537 no 3083 0.105975414524426 4329 817940 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.25133928906234 0.0971859154023219 no 3084 0.10540535846386 4351 5106787 A p450 inhibitor. SGTC_10 0279-0212 42.575 µM -1.25237963837275 0.0969938206562259 no 3085 0.105215781090277 4314 39851 YBR002C RER2 SGTC_1947 st076332 61.6 µM -1.25383511819264 0.0967255423056859 no 3086 0.104950970884508 4210 24208416 SGTC_1292 0kpi-0043 232 µM -1.25534652598818 0.0964475323480621 no 3087 0.104676496135853 4351 3333905 SGTC_1766 st045414 44.774 µM -1.25806318574247 0.0959493039637551 no 3088 0.104184452958893 4340 253960 SGTC_3023 9089636 49.47 µM -1.25988777195646 0.0956157437263003 no 3089 0.103854925255318 4399 17249241 SGTC_2787 5284540 71.43 µM -1.26037024943841 0.0955276828180051 no 3090 0.103767914375968 4359 736958 SGTC_3036 9090181 49.47 µM -1.26053147204654 0.0954982700712906 no 3091 0.103738850984691 4383 25236586 SGTC_2627 acetyl isogambogic acid 100 µM -1.26085854768221 0.0954386203025525 no 3092 0.103679907625955 4346 6857789 A caspase activator and apoptosis inducer. SGTC_2904 7225135 42.03 µM -1.26164121664228 0.0952959939469723 no 3093 0.103538958971429 4411 4446116 SGTC_2264 7948757 110.76 µM -1.26210434042967 0.0952116724860401 no 3094 0.103455621824172 4293 2971411 SGTC_347 4534-1311 26.2 µM -1.26254695943767 0.0951311357109907 no 3095 0.103376019935364 4337 2862016 SGTC_3279 9140807 49.47 µM -1.26461181555387 0.0947560875584033 no 3096 0.103005257706678 4385 45595718 SGTC_2832 7992762 51.95 µM -1.26765221720193 0.0942058322892335 no 3097 0.102461087833826 4285 2985177 SGTC_2234 tolnaftate 200 µM -1.26810110645521 0.0941247919126203 no 3098 0.102380923230496 4426 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2830 7992007 71.43 µM -1.26920841805537 0.0939251029717374 no 3099 0.102183369733256 4214 1952075 SGTC_1111 tnp00062 510.699 nM -1.26947120422586 0.0938777589136156 no 3100 0.102136527259416 4372 676306 SGTC_2232 chlorophetanol 41.5365 µM -1.26947277917318 0.0938774752212092 no 3101 0.102136246567131 4408 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3267 9137951 49.47 µM -1.27585764185339 0.0927325757607938 no 3102 0.101002923445054 4397 16643986 SGTC_560 2332-1943 155 µM -1.28089229206257 0.0918370959909971 no 3103 0.100115750279412 4336 21177716 SGTC_1990 st072050 59.8 µM -1.28845182478755 0.0905045847642917 no 3104 0.0987943641997999 4349 17233948 SGTC_617 3770-0098 35 µM -1.28991880252696 0.0902476734932136 no 3105 0.0985394258517746 4279 5962639 SGTC_1901 st060216 58.6 µM -1.29214933746894 0.0898580792825334 no 3106 0.0981527163228109 4323 688792 SGTC_1898 st060199 18.6 µM -1.29320258181137 0.0896745504706093 no 3107 0.0979705014776482 4333 688866 SGTC_832 4083-0019 164 µM -1.29368937658149 0.0895898202584073 no 3108 0.097886368144436 4450 1990758 SGTC_2378 9074213 121.43 µM -1.29639575907109 0.0891198397355402 no 3109 0.097419586211934 4326 657714 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.29657056416898 0.0890895469216937 no 3110 0.0973894930249405 4405 1609 A potent and irreversible inhibitor of serine proteases. SGTC_690 glyoxal 20.3 µM -1.29722205060605 0.0889767152142031 no 3111 0.0972773978775243 4168 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_697 0508-1955 564 µM -1.30302395775583 0.0879765642992992 no 3112 0.0962832912386826 4359 6243113 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.30553162947143 0.0875468880587222 no 3113 0.0958559420858059 4344 6312947 SGTC_879 0831-1030 162 µM -1.30664050556462 0.0873573881483567 no 3114 0.0956674165723225 4375 1549252 SGTC_2053 5265679 138 µM -1.30806425705361 0.0871145272040523 no 3115 0.0954257577363433 4276 764595 SGTC_1802 st050112 57.9 µM -1.31160030063693 0.0865135370731268 no 3116 0.094827515775105 4374 4662563 SGTC_2477 5967686 25.23 µM -1.31211723510669 0.0864259385993636 no 3117 0.0947402907847113 4362 776118 SGTC_2095 5432005 200 µM -1.31365939738738 0.0861650015346025 no 3118 0.0944804252138869 4382 783734 SGTC_578 3460-0051 92 µM -1.31405226334364 0.0860986220817035 no 3119 0.0944143085130279 4428 2876744 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.31608824108625 0.0857552317835222 no 3120 0.0940722136231578 4438 279621 SGTC_1052 3253-3998 198 µM -1.32875506773323 0.0836418280857925 no 3121 0.0919643952679981 4323 5450317 SGTC_2414 st077232 92.9 µM -1.32878447128322 0.083636968175977 no 3122 0.0919595434070514 4325 729801 SGTC_1902 st060212 70.5 µM -1.33277278949609 0.0829797308768141 no 3123 0.0913031889218868 4395 688944 SGTC_610 4215-0184 155 µM -1.33602021268647 0.0824474615786508 no 3124 0.0907713333904142 4397 5605015 SGTC_2031 5180455 200 µM -1.33823834112169 0.0820853791945065 no 3125 0.0904093771401693 4380 29949 SGTC_327 1273-0057 3.96 µM -1.34068644824427 0.0816871477287877 no 3126 0.0900111381457218 4290 3108138 SGTC_2317 5986382 200 µM -1.34546561173846 0.0809139250250034 no 3127 0.0892374596325896 4423 877883 SGTC_995 3931-2021 34.6 µM -1.34598894046638 0.0808295922320751 no 3128 0.0891530416591206 4406 730143 SGTC_2026 5148700 152 µM -1.35185139683703 0.079889406459308 no 3129 0.0882114291880841 4382 79838 SGTC_2170 morpholine 200 µM -1.35314017426934 0.0796838333319967 no 3130 0.0880054266642574 4440 121171 Reacts with secondary amines. SGTC_583 1488-1091 88.9 µM -1.35356605510139 0.0796159890463247 no 3131 0.087937431355311 4502 4303273 SGTC_630 4356-0227 183 µM -1.3536441044863 0.0796035602501275 no 3132 0.0879249743906473 4352 779312 SGTC_2058 5236698 133 µM -1.35786497389943 0.0789336017268425 no 3133 0.0872532666665572 4370 766665 SGTC_1914 st062367 72.6 µM -1.36326450936741 0.0780827967721532 no 3134 0.0863995814755242 4395 978205 SGTC_2203 7227154 166.4 µM -1.36367063845485 0.0780190854117033 no 3135 0.0863356244988044 4439 896304 SGTC_2059 5238311 157 µM -1.37126312149967 0.0768352662099491 no 3136 0.0851464737365026 4368 703021 SGTC_20 0481-0013 4.944 µM -1.37431467478007 0.0763633343537046 no 3137 0.0846720062268965 4460 182045 SGTC_410 α-linolenic acid 100 µM -1.38174664361424 0.0752231880798908 no 3138 0.0835247535645912 4452 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3280 9140961 49.47 µM -1.38242447832009 0.0751198500336984 no 3139 0.0834207021969506 4459 4901226 SGTC_629 3448-6466 76.7 µM -1.38684951404388 0.0744478975766743 no 3140 0.0827438275879421 4443 573744 SGTC_1897 st060201 15 µM -1.38713590437542 0.0744045671232397 no 3141 0.0827001627673037 4444 611878 SGTC_1256 0570-0116 285 µM -1.3913063170444 0.0737757692897461 no 3142 0.0820662795328041 4425 410638 SGTC_339 3091-4833 71.4 µM -1.39475402667661 0.0732590112824025 no 3143 0.0815450133506097 4263 3240077 SGTC_723 4182-0001 115 µM -1.39515103132861 0.0731996846953734 no 3144 0.0814851500767771 4447 744821 YLR208W SEC13 SGTC_3002 9075603 71.4286 µM -1.39690084271814 0.0729386387327031 no 3145 0.0812216955805773 4384 20105405 SGTC_2922 7999257 32.47 µM -1.3995146046587 0.0725500321369705 no 3146 0.080829360944754 4400 2988377 SGTC_1669 st015249 58.4 µM -1.40262365518103 0.0720898549044733 no 3147 0.0803645470210067 4564 722793 SGTC_2679 rapamycin 1 nM -1.40458251468885 0.071801070986284 no 3148 0.0800727295489906 4304 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3169 9102970 49.47 µM -1.40474997014826 0.0717764251714982 no 3149 0.0800478203980515 4515 17027839 SGTC_2726 cimetidine 79.27 µM -1.40917557104558 0.0711274218162674 no 3150 0.0793916296694628 4424 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1466 k213-0079 57.5 µM -1.41489141149361 0.0702958878781367 no 3151 0.0785501682587048 4408 3657981 SGTC_767 0929-0023 86 µM -1.41644236065124 0.0700715520288839 no 3152 0.0783230143990915 4474 1204563 SGTC_3223 9129970 49.47 µM -1.42284859913461 0.0691507585804506 no 3153 0.077390024740807 4472 17248386 SGTC_482 fipronil 114 µM -1.42933251119825 0.0682283231177231 no 3154 0.0764543429397559 4562 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2062 5245942 200 µM -1.43271910465137 0.0677503189826634 no 3155 0.0759690637617352 4489 1376160 SGTC_75 0159-0059 199.013 µM -1.43277371562084 0.0677426321105175 no 3156 0.0759612575866543 4519 5377270 SGTC_2987 9018338 71.43 µM -1.43421812441295 0.0675395660257276 no 3157 0.0757550132309483 4470 5055682 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.434478257824 0.0675030445080907 no 3158 0.0757179146499106 4458 6708561 SGTC_1960 st011366 51.8 µM -1.4385342110319 0.0669355796503756 no 3159 0.0751412689015085 4484 3972846 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.44193778901357 0.0664622415942402 no 3160 0.0746599622374001 4528 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_555 4296-0685 37 µM -1.44396901904651 0.066180994192363 no 3161 0.0743738451264604 4449 2908540 YHR072W ERG7 SGTC_3161 9100388 49.47 µM -1.4462256776431 0.0658696155509425 no 3162 0.074056956927896 4534 25236368 SGTC_754 3474-0146 171 µM -1.45034028149978 0.0653047974482606 no 3163 0.0734818256714069 4456 24762078 SGTC_3326 9140064 16.379 µM -1.45916992089545 0.064105427607813 no 3164 0.0722591726981298 4429 1868434 SGTC_3196 9111891 49.47 µM -1.4602086169798 0.063965469906624 no 3165 0.0721163739080326 4456 18891510 SGTC_3243 9134147 49.47 µM -1.46051336326592 0.06392445239501 no 3166 0.0720745187959453 4559 24282180 SGTC_332 4112-0506 40.9 µM -1.46512743899646 0.0633059144276954 no 3167 0.0714430758652116 4459 2790355 SGTC_1786 berberine 21.6 µM -1.46864745780719 0.0628371808293441 no 3168 0.0709642177798359 4381 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.46963215454455 0.0627065416327919 no 3169 0.0708307033792652 4552 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1613 st002381 52.1 µM -1.46965002434597 0.0627041728126719 no 3170 0.0708282822084831 4473 551167 SGTC_830 4076-0286 57.8 µM -1.47169717407154 0.0624332640650928 no 3171 0.0705513355333697 4517 6866659 SGTC_1707 st032323 6.317 µM -1.47667050456573 0.061778922134072 no 3172 0.0698819911546661 4302 3132057 YMR211W DML1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.4775739382912 0.0616606338603573 no 3173 0.0697609271666116 4458 442882 SGTC_1504 k297-0033 30 µM -1.47798856586949 0.0616064051314904 no 3174 0.0697054193707762 4379 4388117 SGTC_947 3447-0010 211 µM -1.49018054595164 0.0600284163239401 no 3175 0.0680883850664507 4445 748350 SGTC_1213 1315-0166 115 µM -1.49396174860218 0.0595455052222018 no 3176 0.0675928087095598 4490 768401 SGTC_1189 1431-2119 7.28 µM -1.49785522496017 0.0590514423804189 no 3177 0.0670854344828778 4477 3107275 SGTC_3130 9127414 49.47 µM -1.49905502923934 0.0588998430607309 no 3178 0.0669296783739875 4527 1494646 SGTC_2984 9022109 38.96 µM -1.49923868517238 0.0588766644879639 no 3179 0.0669058612481048 4507 6459207 SGTC_582 0987-0078 156 µM -1.50165072372562 0.0585729133873506 no 3180 0.0665936680701791 4540 1625765 SGTC_94 0334-0113 514.748 µM -1.507126560725 0.0578879016813677 no 3181 0.0658891099184863 4517 6795178 SGTC_640 3381-0960 37.1 µM -1.51380811005976 0.0570606067423323 no 3182 0.0650372575453076 4548 1745025 SGTC_3193 9111931 49.47 µM -1.52766222097946 0.0553748970646813 no 3183 0.0632982123082142 4505 17087244 SGTC_1181 1222-0449 220 µM -1.52874808540899 0.0552444533673261 no 3184 0.0631634533489952 4547 658318 SGTC_428 3448-4153 16.5 µM -1.52921625798032 0.0551882872429051 no 3185 0.0631054207323493 4470 3834874 SGTC_2805 7950783 58.44 µM -1.53599399006623 0.0543802137670329 no 3186 0.0622699271724601 4515 1178958 YDL195W SEC31 SGTC_2759 disulfiram 3.38 µM -1.53768370869293 0.0541802221513566 no 3187 0.0620629844389443 4425 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2979 9012552 45.46 µM -1.53778059215431 0.0541687728908387 no 3188 0.0620511352406444 4527 17100905 SGTC_460 trequinsin 123 µM -1.5397730032695 0.0539337428231172 no 3189 0.0618078473502019 4595 5537 A vasodilator. SGTC_1025 k007-0731 70 µM -1.5403271729733 0.0538685152139699 no 3190 0.0617403117201134 4498 6256118 SGTC_2452 5863136 48.41 µM -1.54277800994144 0.0535807922386717 no 3191 0.0614423233438236 4466 2184096 SGTC_1134 3477-0009 42.5 µM -1.54806351426556 0.0529644298548442 no 3192 0.0608035026975747 4549 3973534 SGTC_3241 9133421 49.47 µM -1.55428836115606 0.0522457532096632 no 3193 0.0600578242533881 4604 17018221 SGTC_1614 st002383 48.6 µM -1.55430448439851 0.052243901840708 no 3194 0.0600559021797117 4556 1947235 SGTC_1393 3470-5649 58.2 µM -1.5555266804266 0.0521037134405879 no 3195 0.0599103426905196 4522 4108395 SGTC_1784 st039334 36.3 µM -1.56070214132398 0.0515133862675106 no 3196 0.0592970229018592 4528 3496984 SGTC_931 2812-0076 566 µM -1.56228632459936 0.0513337570369328 no 3197 0.059110276087184 4456 3450959 SGTC_2465 5809242 33.21 µM -1.56292538535455 0.0512614356574238 no 3198 0.059035072984385 4600 2731748 SGTC_3046 9092212 49.47 µM -1.56757100590391 0.0507381325601156 no 3199 0.0584906415278233 4599 25236637 SGTC_1943 st076331 65.2 µM -1.57684297690646 0.0497064202541181 no 3200 0.0574158300189096 4525 24208415 SGTC_1957 st077035 62.4 µM -1.57802029297638 0.049576623928161 no 3201 0.0572804739462911 4551 705593 SGTC_1228 0124-0032 52.5 µM -1.58000954841868 0.0493579279508643 no 3202 0.0570523399062277 4554 X1228 SGTC_1478 0453-0656 35.7 µM -1.58102411278392 0.0492466851135163 no 3203 0.0569362622511248 4570 5258496 SGTC_3192 9110362 49.47 µM -1.58395917802345 0.048925994266528 no 3204 0.0566015045255336 4523 16649480 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.58588863502217 0.0487160886216383 no 3205 0.0563822871760401 4477 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2470 5664817 21.68 µM -1.58784578348639 0.0485039064448623 no 3206 0.0561606078707125 4600 2859561 SGTC_3191 9110352 49.47 µM -1.60068701801174 0.0471300086222707 no 3207 0.0547231289620563 4497 17122424 SGTC_2087 5276107 200 µM -1.60138179832117 0.0470565722076871 no 3208 0.0546461908311437 4537 144405 SGTC_1697 st025554 27.742 µM -1.60537113581792 0.0466366840063821 no 3209 0.0542060763330348 4568 1269519 SGTC_2731 amoxapine 43.43 µM -1.61361918967469 0.0457780894326866 no 3210 0.0533050259356125 4702 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2652 actinonin 100 µM -1.62302764372662 0.0448142613424933 no 3211 0.0522917478041013 4606 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1816 st051957 91.6 µM -1.62357049151499 0.0447591528967003 no 3212 0.052233753748251 4570 674121 SGTC_1485 3909-9022 254 µM -1.62777307068985 0.044334362671332 no 3213 0.0517865063027279 4616 714516 SGTC_1380 2291-0730 164 µM -1.62956479439233 0.0441542486449664 no 3214 0.0515967550838801 4567 2999191 SGTC_1190 1486-1332 13 µM -1.63124532318685 0.0439858491261842 no 3215 0.051419282681802 4545 4150046 SGTC_1905 st060207 84.5 µM -1.63181206252723 0.0439291752176976 no 3216 0.051359541712852 4551 1948547 SGTC_233 rapamycin 362 pM -1.6388838936511 0.0432269331270927 no 3217 0.0506187213463291 4575 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3198 9112019 49.47 µM -1.63985080041399 0.0431316264691002 no 3218 0.0505180963242519 4600 45595555 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.64201216121277 0.0429191978577493 no 3219 0.0502937419037892 4540 5379071 SGTC_338 4055-0136 114 µM -1.64377428269589 0.0427466346518272 no 3220 0.050111417713557 4545 2900563 SGTC_168 3970-0862 530.542 µM -1.66267062587765 0.0409311652405429 no 3221 0.0481891925948709 4495 3135186 SGTC_528 3492-0019 172 µM -1.6704147871743 0.0402054433861002 no 3222 0.0474186629960438 4575 2869262 SGTC_1335 1486-0900 202 µM -1.6727378057851 0.0399897977750335 no 3223 0.0471894616272176 4578 X1335 SGTC_3167 9103034 49.47 µM -1.68277933468053 0.0390684319779454 no 3224 0.04620890848455 4650 5127859 SGTC_2486 5283202 22.39 µM -1.68516468465083 0.0388521225179492 no 3225 0.0459784012685102 4578 1377751 SGTC_1274 0865-0114 173 µM -1.690231310319 0.0383959042104085 no 3226 0.0454918552419135 4576 870624 SGTC_1362 1611-0397 101 µM -1.69975215294145 0.0375504275410892 no 3227 0.0445887774568538 4587 27816 SGTC_481 bay k-8644 50 µM -1.70001132269934 0.0375276268297312 no 3228 0.0445643978793658 4560 2303 A calcium channel antagonist. SGTC_1919 st067113 52.3 µM -1.70600942872816 0.0370030885664164 no 3229 0.0440031620547233 4559 1268243 SGTC_1865 st057639 52.2 µM -1.70803369367822 0.036827423706543 no 3230 0.0438150453736374 4600 688818 SGTC_2762 leflunomide 42.06 µM -1.71079955615792 0.0365885063405246 no 3231 0.0435590607769269 4560 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_29 0299-0004 12.984 µM -1.71515913181525 0.0362144985402685 no 3232 0.0431580277090541 4529 16871 A napthoquinone isolated from Swertia calycina. SGTC_2750 bromebric acid 70.15 µM -1.71895200583642 0.0358916595967434 no 3233 0.0428115556945897 4580 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1307 1187-1599 12.2 µM -1.7196711782748 0.035830712338548 no 3234 0.0427461148568751 4613 1538471 SGTC_2962 9082311 13.18 µM -1.72062580110965 0.0357499425234345 no 3235 0.042659374222403 4575 16459453 SGTC_2587 piperic acid 92.2 µM -1.72466545989502 0.0354098004689554 no 3236 0.0422938895549555 4539 5370536 SGTC_244 nsc-207895 1.295 µM -1.72909779061288 0.0350396532307804 no 3237 0.0418957972654571 4407 42640 SGTC_3301 9125354 19.7965 µM -1.73233069327698 0.0347716786372955 no 3238 0.0416073500484975 4574 41905162 SGTC_1197 1601-0112 267 µM -1.73241317541169 0.0347648637869178 no 3239 0.041600011897312 4569 7350313 SGTC_1459 k035-0031 35.7 µM -1.7359588395735 0.0344729486996273 no 3240 0.0412855563452827 4358 3877128 YMR208W ERG12 SGTC_247 mechlorethamine 29.705 µM -1.74982531608007 0.0333505962277156 no 3241 0.040074230427847 4586 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1518 st038567 90.8 µM -1.75584642724461 0.0328727057478195 no 3242 0.0395573172628807 4583 77966 SGTC_2293 7624732 200 µM -1.75673930568466 0.032802321690574 no 3243 0.039481127305136 4514 894453 SGTC_2654 protoveratrine a 100 µM -1.7571092887107 0.0327731929998612 no 3244 0.0394495913882565 4627 5702278 A heart drug and vasodilator. SGTC_371 0195-0006 7.36 µM -1.76316061986419 0.0322997921760187 no 3245 0.0389367017502075 4464 3928593 SGTC_820 1582-0060 59.9 µM -1.76878058923362 0.0318652051848645 no 3246 0.0384652486350644 4647 3848840 SGTC_1999 st074831 12.5 µM -1.76956350435272 0.0318050481568299 no 3247 0.0383999415231986 4599 17112523 SGTC_1121 fusaric acid 630.51 nM -1.78570778765447 0.0305853357920158 no 3248 0.037073291890989 4592 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1092 toremifene 6.32 µM -1.78582418948562 0.0305766842422481 no 3249 0.0370638644032293 4619 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_513 4245-1575 41.7 µM -1.78668666393322 0.0305126440777148 no 3250 0.0369940728608925 4447 719745 SGTC_1986 st071812 45 µM -1.78813609360928 0.030405271778765 no 3251 0.0368770268197273 4579 11838594 SGTC_473 2-arachidonoylglycerol 10 µM -1.79011626623776 0.0302590887376526 no 3252 0.0367176111782849 4492 5282280 An endocannabinoid. SGTC_1992 st073643 23.3 µM -1.79530455516319 0.0298788322320089 no 3253 0.036302594845127 4623 3161292 SGTC_2276 7947513 42.08 µM -1.79575362578632 0.0298461064693065 no 3254 0.0362668545312006 4542 2105100 SGTC_1128 3448-9350 235 µM -1.79719938755434 0.0297409493080487 no 3255 0.0361519858724317 4581 619386 SGTC_2796 7949634 45.45 µM -1.79970783993775 0.0295592270285127 no 3256 0.0359533912619143 4591 2971588 SGTC_299 1273-0059 1.44 µM -1.7999622929498 0.0295408450348037 no 3257 0.0359332961915372 4385 2848077 SGTC_2405 ticlatone 3.52 µM -1.80489013492644 0.0291867189749787 no 3258 0.0355459379118606 4436 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2259 7964009 200 µM -1.80755440979575 0.0289967313628951 no 3259 0.0353379396147151 4633 313134 SGTC_954 1189-0853 2.85 µM -1.81026977176052 0.0288041593874729 no 3260 0.0351269811567112 4578 2828194 SGTC_1822 st052468 42 µM -1.81341374824991 0.0285825197514941 no 3261 0.034884015330417 4648 2873678 SGTC_74 000s-0487 160.283 µM -1.8195742716089 0.028152336102947 no 3262 0.0344119313600696 4517 677548 SGTC_1331 1472-0049 76.2 µM -1.82854631490385 0.0275354792352484 no 3263 0.03373380067732 4622 24051409 SGTC_1819 st053448 58.6 µM -1.83204645832208 0.0272979080498262 no 3264 0.033472249634152 4593 2857616 SGTC_231 b-estradiol 524 µM -1.83211840797955 0.027293042478394 no 3265 0.0334668906999144 4645 450 A steroid. SGTC_909 3448-9333 149 µM -1.8363075265111 0.0270109993371102 no 3266 0.033156093624858 4578 3344074 SGTC_2431 5490079 200 µM -1.84152295327754 0.0266632609812521 no 3267 0.0327724800483455 4649 5722345 SGTC_550 4123-0385 25.7 µM -1.85120995749056 0.0260273015852928 no 3268 0.0320696768996306 4665 5731123 SGTC_2614 arthonioic acid 13.39 µM -1.85210559858216 0.0259691482263709 no 3269 0.0320053303669876 4515 6710684 SGTC_3172 9105863 49.47 µM -1.85625966005792 0.0257008472240972 no 3270 0.0317082780092945 4734 2348785 SGTC_370 0180-0345 38.7 µM -1.86008404945552 0.0254558941520927 no 3271 0.0314368177539329 4521 3989527 SGTC_1168 k815-0004 80.5 µM -1.87498188737721 0.0245202504488286 no 3272 0.0303976076862848 4649 642433 SGTC_724 3910-0327 137 µM -1.88302441695803 0.0240272589820995 no 3273 0.0298485295251686 4666 2885483 SGTC_2773 thioridazine 9.09 µM -1.88341059790195 0.0240037979175836 no 3274 0.0298223726146874 4640 5452 An antipsychotic. SGTC_331 k048-0133 24.5 µM -1.88443527662728 0.0239416404493414 no 3275 0.0297530609533519 4643 6813582 SGTC_3008 9078912 71.4286 µM -1.88543102742188 0.0238813674119794 no 3276 0.0296858341452193 4652 16648731 SGTC_377 3970-0964 33.1 µM -1.88932612996318 0.0236468197464952 no 3277 0.0294240711695693 4637 16481235 SGTC_1425 4048-4433 7.33 µM -1.90828781987273 0.0225325146780333 no 3278 0.028177013194242 4714 23734946 SGTC_2779 methotrexate 400 µM -1.93390467791911 0.0210976941359386 no 3279 0.0265624244371238 4644 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1202 1988-0068 29.6 µM -1.93853455220893 0.0208467978101012 no 3280 0.0262790197917695 4651 2850480 SGTC_1298 1079-1278 263 µM -1.94294329922784 0.0206102369676657 no 3281 0.0260115047692351 4650 2840950 SGTC_2197 6588183 93.1375 µM -1.94698601900433 0.0203953185174559 no 3282 0.0257682054246973 4698 884136 SGTC_3171 9103192 49.47 µM -1.95812164463583 0.0198131262910142 no 3283 0.025107870261567 4716 13018434 SGTC_2565 isoliquiritigenin 100 µM -1.96395238340288 0.0195139515629555 no 3284 0.0247678070889453 4627 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3184 9108758 49.47 µM -1.9820270531283 0.018610811321168 no 3285 0.0237381064451304 4728 902885 SGTC_2776 terbinafine 19.92 µM -1.99596867413878 0.0179387237450202 no 3286 0.0229686663365176 4676 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2529 gangaleoidin 93.61 µM -2.00812493068313 0.0173697034153766 no 3287 0.02231500881463 4663 4565183 SGTC_613 3914-0030 117 µM -2.01639945581137 0.0169912611308836 no 3288 0.0218791111896575 4473 1145395 SGTC_1481 3346-2004 36 µM -2.02346363361689 0.0166737744804652 no 3289 0.0215126846509482 4747 2770522 SGTC_514 4466-0038 2.65 nM -2.02441199651112 0.0166315409388149 no 3290 0.0214638892204063 4518 5722064 SGTC_1387 3342-1166 1.8 µM -2.04053883225015 0.0159272554827558 no 3291 0.0206483437167798 4702 3418228 SGTC_2502 avocadyne acetate 18.59 µM -2.0462236033068 0.0156851631296045 no 3292 0.0203671880540455 4674 3952079 SGTC_1337 1486-1011 40.3 µM -2.0521889220583 0.0154345245816683 no 3293 0.020075652832566 4708 X1337 SGTC_2484 5809818 12.04 µM -2.06187657716687 0.0150348146062826 no 3294 0.0196097440259155 4666 2870548 SGTC_441 propafenone 146 µM -2.07150058251542 0.0146465724976553 no 3295 0.0191560200360191 4698 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1076 itraconazole 331 nM -2.08174675903978 0.0142427426070273 no 3296 0.0186828035769295 4707 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_363 0455-0021 3.06 µM -2.0941020474978 0.0137685747123463 no 3297 0.0181254453647478 4633 4597466 SGTC_1057 3448-5381 134 µM -2.10415836023813 0.0133927489657144 no 3298 0.0176823177210275 4693 5497911 SGTC_2534 helenine 20.12 µM -2.1049504812125 0.0133635257137036 no 3299 0.0176478093812636 4696 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2775 cyproheptadine 69.59 µM -2.10585128798014 0.0133303597167132 no 3300 0.0176086360609549 4700 2913 A selective serotonin reuptake inhibitor. SGTC_2600 tangeritin 87.95 µM -2.12136062483202 0.0127703854982712 no 3301 0.0169457330794292 4661 68077 A bioactive flavone. SGTC_1904 st060225 78 µM -2.12248339469446 0.0127306489787069 no 3302 0.0168985828372367 4694 66595 SGTC_960 1222-0186 7.7 µM -2.1311002667549 0.0124292305050621 no 3303 0.0165404413768855 4699 3126296 SGTC_765 1319-0117 244 µM -2.15035672257116 0.0117778964602635 no 3304 0.015763504407722 4694 3487746 YGL099W LSG1 SGTC_3163 9099914 49.47 µM -2.15097436246949 0.0117575049869212 no 3305 0.01573911165703 4767 16268368 SGTC_870 0573-2213 57.6 µM -2.1644515426865 0.0113201201154227 no 3306 0.0152148558637866 4722 3916321 SGTC_340 k038-0059 454 µM -2.16574356472249 0.0112789415927073 no 3307 0.0151653940093687 4721 23733424 SGTC_1174 0739-0097 51.1 µM -2.19061338817769 0.0105112987543135 no 3308 0.0142398907431549 4744 728447 SGTC_1290 0986-0249 10.2 µM -2.19443832889655 0.0103973690964786 no 3309 0.0141019564803421 4635 53329 SGTC_423 5-fluorouracil 457 µM -2.20149785208167 0.0101899186751858 no 3310 0.0138503992928401 4668 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2992 9074591 71.4286 µM -2.23201241997474 0.00933420498943066 no 3311 0.0128070710399522 4681 17741321 SGTC_614 0462-0418 107 µM -2.24054619395889 0.00910643605135892 no 3312 0.012527742677264 4575 5188303 SGTC_1124 fisetin 1.16336 µM -2.25925966157035 0.0086239364089737 no 3313 0.0119336187788895 4729 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1367 1812-0510 76.9 µM -2.26109828209792 0.00857776245084741 no 3314 0.0118765858723326 4743 1142582 YDR527W RBA50 SGTC_755 1995-0008 37.3 µM -2.31127844053832 0.00739856033827315 no 3315 0.0104087400382672 4741 689533 SGTC_1102 cgs 12066b 26.1 µM -2.31654974527853 0.00728339336803001 no 3316 0.0102641358197538 4759 6438352 A 5-HT1B full agonist. SGTC_1864 st057645 30.4 µM -2.33606724673485 0.00687062046600931 no 3317 0.00974386851285815 4771 688666 SGTC_412 gemfibrozil 100 µM -2.33815479377916 0.00682771827482042 no 3318 0.00968960981497715 4731 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2319 6033012 152.6 µM -2.36380673720824 0.00631953335164672 no 3319 0.00904412291433337 4720 847246 SGTC_2120 5538279 151.968 µM -2.39038258556999 0.00582864096991045 no 3320 0.00841541490988263 4761 2058197 SGTC_708 3448-5400 146 µM -2.40919826945221 0.00550184713533395 no 3321 0.00799380493032128 4732 3462195 SGTC_430 0958-0115 16.4 µM -2.44155633970066 0.00497776598040222 no 3322 0.00731205313686316 4712 6833180 SGTC_1126 isoteolin 1.0172 µM -2.44204489748912 0.00497020615168206 no 3323 0.00730216511464283 4722 133323 SGTC_1915 st067105 30.6 µM -2.44911569267332 0.00486193379018825 no 3324 0.00716037206772345 4709 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2173 5763948 167 µM -2.45689441555113 0.00474525415381716 no 3325 0.00700719345138323 4757 2867177 SGTC_404 fumagillin 50 µM -2.46639743735214 0.00460610351440142 no 3326 0.00682399036795537 4756 12015870 A methionine aminopeptidase binder. SGTC_9 0092-0002 10.449 µM -2.47947280492457 0.0044205983831466 no 3327 0.00657883816590126 4759 759368 SGTC_1037 k284-1091 78.7 µM -2.48626687043401 0.00432686812908907 no 3328 0.00645455595482805 4734 3334711 SGTC_1036 k216-0215 33.5 µM -2.49513253015041 0.00420723131033517 no 3329 0.00629550467836591 4729 622330 SGTC_2990 9074105 71.4286 µM -2.52447656954214 0.00383206955112388 no 3330 0.00579353643834848 4729 6502001 SGTC_304 1310-0298 97 µM -2.55152611678976 0.00351310171394737 no 3331 0.00536261427277501 4578 1550234 SGTC_300 r073-0011 5.04 µM -2.55250152975027 0.00350205863007999 no 3332 0.00534762199372142 4782 2735780 SGTC_771 0250-0039 27.3 µM -2.6947075809106 0.00218915404324292 no 3333 0.00352252142858224 4767 3005115 SGTC_1328 1441-0025 69.2 µM -2.74536283090198 0.00184216542957524 no 3334 0.0030222014862175 4789 4562601 SGTC_1108 betulinic acid 729.144 nM -2.74713951553607 0.00183095750178057 no 3335 0.00300587777191914 4753 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_962 1254-0300 21.5 µM -2.75159563427908 0.00180311905990499 no 3336 0.00296528502953078 4782 7340576 SGTC_2018 5133068 143 µM -2.80264515947371 0.00151056038108136 no 3337 0.00253427006862054 4768 785362 SGTC_2956 9076196 2.52 µM -2.81219361545202 0.00146090606131051 no 3338 0.00246024376065484 4774 16423868 SGTC_970 1315-0089 19.5 µM -2.83946430233968 0.00132718243451949 no 3339 0.00225946754864288 4786 6811083 YLR033W RSC58 SGTC_914 3820-6779 408 µM -2.84528068352125 0.00130015041718975 no 3340 0.00221861520023005 4746 2893481 SGTC_3005 9076496 71.4286 µM -2.93177740321774 0.000953287409642362 yes 3341 0.00168514109667297 4787 21368410 SGTC_2459 5811157 9.22 µM -2.94503966236818 0.000908344554225562 yes 3342 0.00161456632886741 4780 2870684 YBR192W RIM2 SGTC_1046 2001-0062 216 µM -3.02040946501571 0.000687849755761529 yes 3343 0.00126216581776404 4785 739778 SGTC_750 4073-0104 132 µM -3.02583331283328 0.000674063375723027 yes 3344 0.00123974475656071 4657 22330957 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -3.0576144116354 0.000598275428248067 yes 3345 0.00111553227002583 4784 364106 SGTC_966 1300-0360 30.2 µM -3.12229075992583 0.000467755880452357 yes 3346 0.000897248071073503 4790 70588 SGTC_2961 9083290 32.55 µM -3.13705018976891 0.000441928841618894 yes 3347 0.000853284554507405 4781 17741490 SGTC_2332 7982454 138.89 µM -3.17835440725251 0.000376509831540399 yes 3348 0.000740567918208565 4771 2981748 SGTC_3206 9114350 49.47 µM -3.18293433665032 0.000369838378640305 yes 3349 0.000728953363989181 4753 17087243 SGTC_1107 amlodipine 47 µM -3.24137884428449 0.000293806654850168 yes 3350 0.000594764927655967 4524 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1045 1348-1485 165 µM -3.44409264843528 0.000128486687311607 yes 3351 0.000286489661405482 4795 6810614 SGTC_711 k292-0785 179 µM -4.48424978892775 9.0528958765548e-07 yes 3352 3.65854541739009e-06 4807 4146315 SGTC_310 1273-0058 1.06 µM -5.10948143681664 2.58029708584987e-08 yes 3353 1.61522113532954e-07 4714 2734232