SGTCid condition conc unit MVB12|YGR206W.score MVB12|YGR206W.strain.pval MVB12|YGR206W.strain.significant MVB12|YGR206W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2021 4019055 173 µM 10.4121898662809 1.81707015959533e-26 yes 1 1.09072471277746e-25 8 44827708 YER133W GLC7
SGTC_1203 3992-3522 103 µM 7.41421024065301 2.33056040904406e-14 yes 2 6.11758482828675e-14 4 5322312
SGTC_1495 4469-0029 237 µM 7.25610609542964 7.87078661520246e-14 yes 3 1.9919632053642e-13 35 793680
SGTC_2688 kanamycin b 96.69 µM 6.56372968184178 1.20636918637724e-11 yes 4 2.62391499374897e-11 124 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_255 tunicamycin 200.472 nM 5.33342790507088 2.80368582747678e-08 yes 5 4.8187918876745e-08 39 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_159 3970-0959 50 µM 5.15437001850119 7.63383776043396e-08 yes 6 1.27242503083941e-07 37 6615653
SGTC_978 1416-0512 87.4 µM 5.12891334028749 8.77931502648731e-08 yes 7 1.45709723145796e-07 11 6814003
SGTC_372 0155-0182 15.9 µM 5.08651815483138 1.10651211032711e-07 yes 8 1.82348412274724e-07 13 771486
SGTC_3308 9128332 17.569 µM 4.80375970934912 4.94694874998566e-07 yes 9 7.78568435638195e-07 51 17332805 YDL196W YDL196W
SGTC_393 acivicin 6.25 µM 4.62746876167503 1.20882053535334e-06 yes 10 1.85081021712279e-06 15 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_212 3807-4682 38.772 µM 4.62182820768871 1.24324253006393e-06 yes 11 1.90186476018624e-06 44 3125501 YBL034C STU1
SGTC_1642 st009582 77.7 µM 4.41132012178987 3.46622370568575e-06 yes 12 5.1371143616185e-06 9 6739311
SGTC_2619 obliquin 87.91 µM 4.39138120494964 3.811074585002e-06 yes 13 5.63164343448682e-06 124 6708593 A bioactive alkalod. YER133W GLC7
SGTC_514 4466-0038 2.65 nM 4.38577665942049 3.91376631059803e-06 yes 14 5.77863296609799e-06 129 5722064
SGTC_1789 tunicamycin 25 nM 4.38088076093119 4.00563364715884e-06 yes 15 5.91002726742507e-06 36 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2753 fluvastatin 17.09 µM 4.26345140711744 6.93864215576632e-06 yes 16 1.00646645484654e-05 25 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1844 rapamycin 4 nM 4.15334083322804 1.1472045003674e-05 yes 17 1.63828072832829e-05 147 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2322 7413319 38.22 µM 4.1486059210867 1.17196485639069e-05 yes 18 1.6725303416831e-05 142 1840400
SGTC_1803 st050068 52.4 µM 4.06154586618717 1.72870903944686e-05 yes 19 2.43744189937591e-05 171 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2937 9044753 11.33 µM 3.9613443429777 2.67920199642393e-05 yes 20 3.72644804231695e-05 31 6465530 YGL099W LSG1
SGTC_671 0560-0003 407 µM 3.86096292067869 4.11472455889105e-05 yes 21 5.64705219004852e-05 11 3238678
SGTC_518 1021-0119 62.6 µM 3.78612390300249 5.62954629963148e-05 yes 22 7.65076999352278e-05 53 1097762
SGTC_168 3970-0862 530.542 µM 3.70899384247149 7.73187229798524e-05 yes 23 0.00010404224385332 134 3135186
SGTC_528 3492-0019 172 µM 3.6643630293308 9.26565257303622e-05 yes 24 0.000123977444137258 246 2869262
SGTC_310 1273-0058 1.06 µM 3.57653370599138 0.000131544729453669 yes 25 0.000174090220301907 280 2734232
SGTC_3162 9099653 49.47 µM 3.54880578351875 0.000146705023716697 yes 26 0.000193491195958909 9 25237511
SGTC_1230 0170-0365 3.77 µM 3.51992696546731 0.000164224315661876 yes 27 0.000215832822075536 91 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 3.5190089468399 0.000164812098890038 yes 28 0.000216581049877832 63 676296 Flavone; oxidizing agent.
SGTC_969 1313-0238 134 µM 3.42447656918624 0.000237063114771787 yes 29 0.00030799247977404 40 5212874
SGTC_974 1326-0144 138 µM 3.40734758638926 0.000252969059661799 yes 30 0.000327987663498115 67 5411856
SGTC_2794 7785382 27.27 µM 3.38753865772728 0.000272602244991599 yes 31 0.000352613890175061 59 2205081
SGTC_1475 4092-1048 11.7 µM 3.30356095961833 0.000372662609147938 yes 32 0.000477326056860961 62 2881759
SGTC_1220 1838-0075 193 µM 3.2930399216439 0.000387363593300387 yes 33 0.000495552004599956 25 5529645
SGTC_1989 st071868 50.2 µM 3.28996781220666 0.000391756718441772 yes 34 0.000500994219880654 26 16414057
SGTC_2582 agaric acid 100 µM 3.28749592945973 0.000395325045692538 yes 35 0.000505413251987114 390 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_214 4373-3496 70 µM 3.26937542005256 0.000422418806111539 yes 36 0.000538925945713599 109 3779166
SGTC_1997 st073024 93.8 µM 3.26251132888078 0.000433124332636594 yes 37 0.000552148794533217 23 686268
SGTC_3021 9087658 49.47 µM 3.25787652932639 0.000440494658302538 yes 38 0.00056124617115326 16 25237042
SGTC_2249 haloperidol 116.36 µM 3.20031461432384 0.000542252232976919 yes 39 0.000686388247075623 166 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1908 st060353 56.5 µM 3.1703054221749 0.000603541940753152 yes 40 0.000761393914936306 73 4227716
SGTC_2481 5478948 45.16 µM 3.15200056591062 0.000644006200875648 yes 41 0.000810779795259949 75 77792
SGTC_1800 st050079 29.0735 µM 3.13499538203124 0.000683826825843285 yes 42 0.000859284084481083 204 3645560
SGTC_379 3970-0972 5.9 µM 3.11291238837597 0.000738928381072248 yes 43 0.000926255009328795 74 2898042 YBL034C STU1
SGTC_1820 st053765 18.6 µM 3.08813513117225 0.000805605549086352 yes 44 0.00100708430296398 56 3690829
SGTC_97 0535-0701 19.132 µM 3.08490889075223 0.000814683801699627 yes 45 0.00101807257894267 53 2832013 YGL099W LSG1
SGTC_1113 artemisinin 1.17947 µM 3.07648532252952 0.000838832350615836 yes 46 0.00104728307313759 40 2240 An anti-malaria and mitochondrial poison.
SGTC_916 4466-0038 42 nM 3.04272283809146 0.000942378419258552 yes 47 0.00117224080153262 134 5722064 YGL116W CDC20
SGTC_2993 9054257 71.4286 µM 2.97605166710933 0.00118209672781855 no 48 0.00145992832433832 106 6470217 YGL055W OLE1
SGTC_522 1273-0010 11.6 µM 2.97017423746562 0.00120570557635174 no 49 0.00148815442899189 59 5705015
SGTC_116 0155-0182 31.788 µM 2.95929943778151 0.00125052954358126 no 50 0.00154169667717857 169 771486
SGTC_816 0325-0417 81.3 µM 2.94581432254564 0.00130822842443725 no 51 0.00161052846410838 53 68101
SGTC_2032 5185112 25.99 µM 2.91171608462838 0.0014651455397641 no 52 0.00179724594914942 52 5718189
SGTC_1492 4158-0558 28.5 µM 2.88161034566507 0.00161776955761495 no 53 0.00197824336413751 58 3967268
SGTC_2765 myclobutanil 7.74 µM 2.88062450342013 0.00162300388502196 no 54 0.00198444082272182 103 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3186 9110464 49.47 µM 2.87318607594121 0.00166299834201873 no 55 0.00203177350265171 48 17018021
SGTC_2919 7978188 46.38 µM 2.85794341173386 0.00174777152727599 no 56 0.00213198212714222 83 2980291
SGTC_749 1000-0129 128 µM 2.85087314943033 0.00178841282129394 no 57 0.00217996796377654 74 708470
SGTC_377 3970-0964 33.1 µM 2.83614079745963 0.00187587195822526 no 58 0.00228311554163954 126 16481235
SGTC_1861 st057647 17.4 µM 2.82956393192314 0.00191615649202291 no 59 0.00233057431554933 69 688668
SGTC_3157 9099274 49.47 µM 2.79120921678626 0.00216715012282054 no 60 0.00262557587105255 55 17217662
SGTC_2019 4016004 108 µM 2.7859243017349 0.00220397854105553 no 61 0.00266876673074923 89 45595336
SGTC_1491 4138-0063 26.5 µM 2.78358605748704 0.00222045307839107 no 62 0.00268807991347849 38 23883227
SGTC_1240 0356-0016 42.1 µM 2.71845289714191 0.00272663347126514 no 63 0.00327939967769918 99 4305613
SGTC_1422 4031-0024 15.5 µM 2.66688829237599 0.00319884792973478 no 64 0.00382785567030748 74 782427
SGTC_1145 3546-0597 10.2 µM 2.66349998335879 0.00323231295487722 no 65 0.0038666207855697 107 875334
SGTC_2837 9008476 45.46 µM 2.655561947058 0.0033119503175614 no 66 0.00395881949570922 121 2992805
SGTC_1223 0764-0573 147 µM 2.61207015842684 0.00378041060136113 no 67 0.0044997891714168 113 1609797
SGTC_2286 7945697 125 µM 2.59950184888359 0.00392643059046362 no 68 0.00466795877849695 151 1245733
SGTC_108 0509-0257 621.132 µM 2.57505522784355 0.00422500137978502 no 69 0.00501120410080737 155 536624
SGTC_308 4092-1169 104 µM 2.55597799434198 0.00447193006855851 no 70 0.00529449075781881 150 2268590 YDL196W YDL196W
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 2.55489303279319 0.0044863531523006 no 71 0.0053110217384182 38 4000243
SGTC_2254 7938975 95.19 µM 2.53056120990823 0.00482091371533233 no 72 0.00569401064781277 159 2969277
SGTC_1923 st058458 19.1 µM 2.51915695828169 0.00498524218937903 no 73 0.00588181024287801 157 3534982
SGTC_1047 2043-3044 82 µM 2.50282307074117 0.00522929420373223 no 74 0.00616035596855544 137 669592
SGTC_346 4513-0042 7.16 µM 2.50208806757348 0.0052405219574186 no 75 0.00617316044019073 130 2827372
SGTC_649 1123-0311 367 µM 2.497349488527 0.00531342371881821 no 76 0.00625627849822885 182 693629 YIL048W NEO1
SGTC_2164 5685496 200 µM 2.49223354375566 0.00539314237835375 no 77 0.00634712689762403 99 759046
SGTC_2847 9005661 71.43 µM 2.4917250586241 0.00540112359361358 no 78 0.00635622000849254 47 2991449
SGTC_1115 galangin 695.678 nM 2.4852633478131 0.00550346534069453 no 79 0.00647278141095703 113 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_211 3455-0679 143.504 µM 2.48291342360746 0.00554110893355336 no 80 0.00651563774513348 122 748649
SGTC_1499 4480-0877 67.3 µM 2.47461503243933 0.00567587802931888 no 81 0.0066689929939926 64 2861909
SGTC_2757 clomiphene 4.22 µM 2.47451961576249 0.00567744440980173 no 82 0.00667077470317919 160 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_416 estradiol valerate 100 µM 2.45185101750988 0.00606063155397546 no 83 0.00710617460098024 110 13791 A steroid.
SGTC_2991 9074669 71.4286 µM 2.44247701053991 0.00622567341901194 no 84 0.00729342931514634 179 17333109
SGTC_558 k064-0027 21.3 µM 2.43635230947413 0.00633564516650152 no 85 0.00741811330955609 129 5088526
SGTC_3106 9121286 49.47 µM 2.42240110331169 0.00659258734628853 no 86 0.00770916092345414 102 15943471
SGTC_512 prima-1 270 µM 2.42057463086108 0.00662689897512119 no 87 0.00774799904042602 108 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_862 0452-0056 10.2 µM 2.41394214180809 0.00675282638395017 no 88 0.00789048403973431 114 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_408 cantharidin 100 µM 2.38722977466662 0.00728166096080514 no 89 0.00848793877031796 146 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2127 5253358 187.912 µM 2.37796643613975 0.00747339800410624 no 90 0.00870420519965817 130 20612
SGTC_1259 0671-0132 43 µM 2.37753764289583 0.00748238009904843 no 91 0.00871433198548692 150 X1259
SGTC_1831 st055328 12 µM 2.3775246697465 0.00748265200069152 no 92 0.0087146385325616 147 1103068
SGTC_922 1866-0035 480 µM 2.36911837326987 0.00766067861647034 no 93 0.00891527283688483 219 3156169
SGTC_1718 roemerine 11.9335 µM 2.36392061211028 0.00777261182477046 no 94 0.00904134351113351 193 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3004 9076122 71.4286 µM 2.35941050297774 0.0078709001064417 no 95 0.00915199769457466 137 44782551
SGTC_2639 lactacystin 53 µM 2.35586120805763 0.00794901653833414 no 96 0.00923991043131857 148 3870 A proteasome inhibitor.
SGTC_2801 7907800 81.82 µM 2.34340554304757 0.00822857362154469 no 97 0.00955430004028268 167 6620925
SGTC_1680 diphenhydramine 100 µM 2.31177178355469 0.00897772410111227 no 98 0.0103951315730069 168 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1728 st035614 33.7865 µM 2.3005474233728 0.00925754990178511 no 99 0.0107086128979663 224 15945546
SGTC_665 3914-0008 307 µM 2.29738374524257 0.00933778738260769 no 100 0.0107984441084066 159 1069549
SGTC_2462 5162487 171.77 µM 2.29715680056208 0.00934356649095954 no 101 0.0108049132434485 140 2259986
SGTC_2859 9028643 45.46 µM 2.29174115236017 0.0094824063973026 no 102 0.0109602921174216 104 17151580
SGTC_217 ketoconazole 989 nM 2.28601286650809 0.00963122129904162 no 103 0.0111267529250251 146 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1086 cerivastatin 2.18 µM 2.28336073344246 0.00970080949265635 no 104 0.0112045641221038 111 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_102 gallobenzophenone 83.616 µM 2.28202305041507 0.00973607476939826 no 105 0.011243989706523 173 70837
SGTC_1493 4348-0038 111 µM 2.27103169612259 0.0100301048782194 no 106 0.0115725296254343 189 800424
SGTC_1658 st012944 20 µM 2.26836906935724 0.0101024883441067 no 107 0.0116533606775234 193 24207260
SGTC_190 3970-0790 3.722 µM 2.26717509124823 0.0101350943631767 no 108 0.0116897659119925 114 2832352
SGTC_653 0203-0016 55.2 µM 2.26015231735161 0.010328741746277 no 109 0.0119058995302949 157 295302
SGTC_54 0159-0055 9 µM 2.25210573649577 0.0105545783453561 no 110 0.0121577954410983 153 3319099
SGTC_1874 staurosporine 7.6 µM 2.24766240608667 0.0106811198781658 no 111 0.0122988624626455 181 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3133 9127736 49.47 µM 2.24153420974664 0.0108578113324939 no 112 0.0124957460751135 146 27243420
SGTC_1009 4106-0057 9.87 µM 2.24091045869926 0.0108759375058663 no 113 0.0125159378246572 139 2928005
SGTC_258 haloperidol 50.781 µM 2.22972893002216 0.0112053684400046 no 114 0.0128827220339162 208 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3183 9108214 49.47 µM 2.21550855555639 0.0116368363700716 no 115 0.0133625888807365 54 4974831
SGTC_576 1073-0113 22.7 µM 2.20770460092245 0.0118796949878299 no 116 0.0136324359534124 276 5439563
SGTC_2533 agelasine 13.65 µM 2.2014985814031 0.0120759528633135 no 117 0.0138503735056251 216 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1109 tnp00067 928.257 nM 2.19580281683876 0.0122585421673819 no 118 0.014053029983784 146 676295
SGTC_847 0342-0274 5.54 µM 2.18875138489002 0.0124879002130682 no 119 0.0143074574771683 152 18097
SGTC_3234 9132280 49.47 µM 2.18644290079913 0.0125637900177135 no 120 0.0143916089167705 182 17612295
SGTC_1310 1188-0297 994 nM 2.18508959374455 0.0126084644119933 no 121 0.0144411390510241 172 1588352
SGTC_644 1498-1197 63.3 µM 2.18477256405617 0.0126189498231513 no 122 0.0144527633191957 189 6741615
SGTC_2843 9000894 45.46 µM 2.18010589859785 0.0127741701151718 no 123 0.0146248063187845 85 2242070
SGTC_2676 harmalol 100 µM 2.16842728911841 0.01316987615725 no 124 0.0150630956371499 150 5459187 A monoamine oxidase inhibitor
SGTC_20 0481-0013 4.944 µM 2.15967789893944 0.0134732305268032 no 125 0.015398806641197 189 182045
SGTC_262 fenpropimorph 62.5 µM 2.15593490111975 0.0136048369343491 no 126 0.0155443743740906 170 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1 0258-0098 57.368 µM 2.15493433719312 0.0136402048199519 no 127 0.0155834864578505 131 6790032 YDR047W HEM12
SGTC_1406 3909-7906 11.9 µM 2.13255331961548 0.0144523207759331 no 128 0.0164806930562575 167 X1406
SGTC_1008 4106-0037 6 µM 2.12672421001278 0.0146705464339556 no 129 0.0167215023670133 153 2905394
SGTC_374 0880-0231 82.3 µM 2.11909284902523 0.0149605240864326 no 130 0.0170413104724237 185 6833587
SGTC_1995 st072814 61.1 µM 2.11773568029628 0.0150126067497905 no 131 0.0170987296428943 175 5769371
SGTC_1717 st033143 58.0435 µM 2.11555581749119 0.0150965872747015 no 132 0.0171913014617247 233 674616
SGTC_1653 st012112 65 µM 2.11519507012903 0.0151105241441335 no 133 0.0172066624756609 154 720429
SGTC_3346 9158254 43.5805 µM 2.10980403485055 0.0153201185236357 no 134 0.0174376193956802 186 17639500
SGTC_1446 4239-0190 62 µM 2.10544822707719 0.0154912839110945 no 135 0.0176261547580112 239 1340085
SGTC_525 k781-2675 26.7 µM 2.10199504101412 0.0156281440427636 no 136 0.0177768551026381 231 3651118 YDL195W SEC31
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.09809242239989 0.0157840640959698 no 137 0.0179484909111692 175 688798
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.09421788369334 0.0159401802276524 no 138 0.0181202876914133 280 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1987 st072290 61.9 µM 2.08762048900382 0.0162090544667332 no 139 0.0184160411408573 181 54697379
SGTC_2793 7325131 81.82 µM 2.05854203150072 0.0174409168539926 no 140 0.0197690654183522 185 4176441
SGTC_288 1315-0019 35.1 µM 2.05001345200047 0.0178170417565401 no 141 0.0201815590644976 214 6811474
SGTC_344 k064-0035 6.43 µM 2.03930256359118 0.0182991927312729 no 142 0.0207099199774313 205 5088750
SGTC_2288 7946289 167.31 µM 2.03462671073276 0.0185131367713767 no 143 0.0209442238149074 240 1246052
SGTC_1766 st045414 44.774 µM 2.0272640944313 0.0188543300224225 no 144 0.0213177057118433 243 253960
SGTC_1437 4092-1038 11.6 µM 2.0243505597017 0.0189908168200804 no 145 0.0214670474475675 207 3977136
SGTC_3164 9100705 49.47 µM 2.02233120517784 0.0190859073175239 no 146 0.0215710734640027 146 17174235
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.01996201961798 0.019197987037421 no 147 0.0216936636416652 186 756377
SGTC_307 1501-1223 22.3 µM 2.01833309953381 0.0192753709660501 no 148 0.0217782908581294 183 2830329
SGTC_1805 st050013 60.3 µM 2.01631383910689 0.0193716663577839 no 149 0.0218835843483992 172 4037144
SGTC_491 tetrandrine 80.3 µM 2.01540750349755 0.0194150208220362 no 150 0.0219309844378474 152 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2035 5154463 94.595 µM 2.01518083887253 0.0194258761761372 no 151 0.0219428522239275 242 2769623
SGTC_686 1319-0111 510 µM 2.01465656353304 0.0194510043709792 no 152 0.0219703231941539 213 4562600
SGTC_2347 9049783 174.81 µM 2.00948260863004 0.0197004731190252 no 153 0.0222429886218539 263 6467988 YPL169C MEX67
SGTC_687 k029-0044 34.9 µM 1.99697945559725 0.0203145639072829 no 154 0.0229137074009686 197 5829338
SGTC_2223 6903751 107.57 µM 1.99047501572597 0.0206403945712317 no 155 0.0232693167683637 150 5598863
SGTC_1010 4112-3296 15.2 µM 1.98603678311873 0.0208652532200186 no 156 0.023514619882044 236 704384
SGTC_986 1493-0483 84 µM 1.9831741233186 0.0210113844300013 no 157 0.0236739916345715 197 40079
SGTC_1635 st007035 42.4 µM 1.98159844406461 0.0210921875942933 no 158 0.0237621007338968 480 3716403
SGTC_202 3594-0513 34.79 µM 1.97350294092704 0.0215114940262111 no 159 0.0242191449150318 163 708429
SGTC_2027 5150920 200 µM 1.97094760988887 0.0216453016238843 no 160 0.0243649343046808 196 786715
SGTC_3202 9113761 49.47 µM 1.97000791940807 0.0216946842089858 no 161 0.0244187314716744 299 4798415
SGTC_670 4204-0025 119 µM 1.96947174330069 0.0217229039451655 no 162 0.0244494721457243 251 719039
SGTC_2108 5365811 200 µM 1.96946210179271 0.0217234116755841 no 163 0.0244500252210979 236 780283
SGTC_2398 5228213 48.84 µM 1.96600575659889 0.0219060730294423 no 164 0.0246489728255235 303 80771 YMR134W ERG29
SGTC_1359 1582-0056 520 nM 1.96359243421237 0.0220343801064172 no 165 0.0247886877480621 260 3661189
SGTC_150 3970-0969 77.2 µM 1.95424249673822 0.0225374863897243 no 166 0.0253362728673829 326 6615640
SGTC_361 000s-0510 1.45 µM 1.95327222029911 0.0225902459049523 no 167 0.0253936736931256 263 660
SGTC_2415 st077333 57.7 µM 1.94440657831895 0.0230771618217275 no 168 0.0259232206068621 328 2766255
SGTC_1418 3966-3099 2.4 µM 1.93837757297082 0.0234133092225114 no 169 0.0262885872643424 257 740335
SGTC_1456 k015-0012 13 µM 1.93593640555634 0.0235505836262991 no 170 0.026437745123443 288 2989616
SGTC_236 1509-0011 5.31 µM 1.93117869372174 0.0238200704672459 no 171 0.0267304789561968 617 3107280
SGTC_183 3914-0051 30.55 µM 1.92538855079053 0.0241515289576893 no 172 0.0270903834337712 242 1596232
SGTC_2915 7971052 15.16 µM 1.922140325911 0.0243391650567929 no 173 0.0272940515488629 145 5741558
SGTC_2075 5212009 200 µM 1.912253349931 0.0249178417441808 no 174 0.027921853102673 190 780898
SGTC_312 4092-0653 6.84 µM 1.8902627035376 0.0262463911540911 no 175 0.0293614171289759 372 1148278
SGTC_3127 9126946 49.47 µM 1.88557962069335 0.026536835731762 no 176 0.0296758128820014 228 27243249
SGTC_3271 9137798 49.47 µM 1.87771296055801 0.0270307679933061 no 177 0.0302102213715863 181 6498326
SGTC_233 rapamycin 362 pM 1.87769030815941 0.0270322012970962 no 178 0.0302117716669934 234 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3086 9117350 49.47 µM 1.8747164673232 0.0272209190934311 no 179 0.0304158701070018 150 2679265
SGTC_973 1325-0077 65.9 µM 1.86712938577983 0.0277073740019694 no 180 0.030941760834286 263 2835149
SGTC_1904 st060225 78 µM 1.86702248043968 0.0277142797903273 no 181 0.0309492242932095 236 66595
SGTC_813 k007-0158 173 µM 1.85310005066803 0.02862596626749 no 182 0.0319340097907816 324 6523916
SGTC_2856 9022925 19.48 µM 1.84228827584384 0.0293510437898784 no 183 0.03271649689687 287 4944862
SGTC_1605 st000082 49.1 µM 1.84112306747921 0.0294300894315863 no 184 0.0328017629935209 247 1114022
SGTC_1450 4112-4260 37.6 µM 1.83782904161242 0.0296545068081035 no 185 0.0330438003864012 280 1633175
SGTC_3012 9080433 71.4286 µM 1.83686754920802 0.0297202790654251 no 186 0.0331147254476485 258 17688859
SGTC_2114 5491910 81.25 µM 1.83252774867099 0.0300186572145329 no 187 0.0334364157403882 253 2849228
SGTC_2602 kawain 100 µM 1.83036290996523 0.0301684243798733 no 188 0.0335978450065369 313 5369129
SGTC_1792 st045773 43.6 µM 1.81756382525353 0.0310665935233801 no 189 0.0345654124254958 294 2919270
SGTC_2584 androsterone 48.74 µM 1.81349556815357 0.0313566734603088 no 190 0.0348777107709045 452 2754130 A steroid.
SGTC_3155 9099265 49.47 µM 1.80859781571118 0.0317088666422022 no 191 0.0352567540452912 260 25236499
SGTC_585 0kpi-0023 191 µM 1.80449789091242 0.032006196213348 no 192 0.0355766447500466 255 64601
SGTC_2933 9026794 32.47 µM 1.79683313831913 0.0325682245773242 no 193 0.0361810568931616 323 17586027
SGTC_788 1182-0090 188 µM 1.79151628424598 0.0329628523166955 no 194 0.0366052419017407 404 5715185
SGTC_2840 9008771 71.43 µM 1.78729046728013 0.0332793044822045 no 195 0.0369452769754971 213 2992978
SGTC_2767 sibutramine 71.45 µM 1.7846098740112 0.0334813358216734 no 196 0.0371623093501496 286 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1950 st077106 7.18 µM 1.78123085537044 0.0337374436862617 no 197 0.0374373724686844 318 13831864
SGTC_610 4215-0184 155 µM 1.77507095582321 0.0342084715533176 no 198 0.0379430859731579 307 5605015
SGTC_2219 9098279 200 µM 1.77139122417371 0.0344924189862874 no 199 0.0382478334639013 267 902349
SGTC_2038 4100038 30.985 µM 1.77132289029213 0.0344977102454868 no 200 0.0382535115502671 320 3596803
SGTC_50 0929-0078 56.389 µM 1.76225048438094 0.0352061529808084 no 201 0.0390134929140114 311 1377751
SGTC_1060 3448-7350 82 µM 1.75920981724602 0.0354462453027304 no 202 0.0392709387021563 332 570178
SGTC_149 3970-0822 46.1 µM 1.75905361426869 0.0354586153217409 no 203 0.0392842012693511 469 3114250 YBL034C STU1
SGTC_1245 0418-0076 17.2 µM 1.75787001108459 0.035552462241145 no 204 0.0393848147474989 316 6790114
SGTC_2666 tannic acid 100 µM 1.75145858922851 0.0360643636325657 no 205 0.0399334742131853 340 16134267 A thiamine antagonist.
SGTC_842 0271-0008 11.1 µM 1.7478076054761 0.0363585530898906 no 206 0.0402486739602094 319 1221709
SGTC_2434 5670830 169.91 µM 1.7442238377187 0.0366492338165511 no 207 0.0405600331152417 342 1549830
SGTC_1102 cgs 12066b 26.1 µM 1.74203628456909 0.0368275995049132 no 208 0.0407510476614155 263 6438352 A 5-HT1B full agonist.
SGTC_711 k292-0785 179 µM 1.73554440487441 0.0373611082206596 no 209 0.041322211719542 301 4146315
SGTC_2970 9090938 41.86 µM 1.73472496659093 0.0374288969258099 no 210 0.041394765959509 407 17217104
SGTC_3126 9127922 49.47 µM 1.72012982204244 0.0386532112092806 no 211 0.0427044229753543 340 45595682
SGTC_992 3909-8734 162 µM 1.71575100219013 0.0390268275651512 no 212 0.0431038127915504 304 4288319
SGTC_487 nimodipine 119 µM 1.711135134738 0.0394238475713869 no 213 0.0435280847681623 207 4497 L-type voltage-gated calcium channels inhibitor
SGTC_493 zm226600 134 µM 1.71102377437113 0.039433466341738 no 214 0.0435383620571581 332 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2024 5144227 134 µM 1.70577733816096 0.0398887962874243 no 215 0.0440247719867401 359 3475211
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.70254099047528 0.0401717986408815 no 216 0.044327000616935 305 803109
SGTC_2307 7538926 6.34 µM 1.69885354615444 0.0404962327996369 no 217 0.0446733908015199 360 96582
SGTC_1304 1165-0502 251 µM 1.69744981089661 0.0406202959732813 no 218 0.0448058260802702 385 767425
SGTC_886 0866-0150 153 µM 1.69519594032503 0.0408201398956654 no 219 0.045019128396902 351 271463
SGTC_1567 st069303 68.4 µM 1.69315223531928 0.0410020379699711 no 220 0.0452132468374795 363 5581319
SGTC_2986 9022445 71.43 µM 1.69252986711691 0.0410575616759488 no 221 0.0452724951896044 318 6459286
SGTC_1734 st037168 69.4 µM 1.69187032652645 0.0411164681953379 no 222 0.0453353504377534 336 708907
SGTC_928 2764-0428 58.7 µM 1.68516860916033 0.0417189227991837 no 223 0.045978022787914 370 662578
SGTC_1644 st010134 20.9 µM 1.68513118729472 0.0417223068238028 no 224 0.0459816318630802 282 3818134
SGTC_1660 st012960 28.1 µM 1.6849438337946 0.0417392523700956 no 225 0.0459997042099151 360 24207266
SGTC_882 0843-0131 351 µM 1.6829251965509 0.0419221856855026 no 226 0.0461947866002103 345 5425421
SGTC_3069 9117009 49.47 µM 1.68245429943063 0.0419649526493979 no 227 0.0462403898386115 215 41904981
SGTC_1255 0566-0045 221 µM 1.68132985756318 0.0420672175419704 no 228 0.0463494307510192 357 2788469
SGTC_3246 9135460 32.98 µM 1.6805515146072 0.0421381237565963 no 229 0.0464250301219635 246 41446951
SGTC_579 4491-1009 110 µM 1.67931031190491 0.042251396074036 no 230 0.0465457911667834 435 1271041
SGTC_380 3970-0968 6 µM 1.67848688281086 0.042326678161985 no 231 0.0466260445332467 323 2891601
SGTC_2201 6605497 169.863 µM 1.67565402975544 0.0425865012330477 no 232 0.0469029895648964 287 670741
SGTC_1377 2944-0135 198 µM 1.66596216601424 0.043485185662015 no 233 0.0478604751361426 373 1894137
SGTC_196 k015-0023 18.111 µM 1.66472039301776 0.0436014281935459 no 234 0.047984276238597 358 5211998
SGTC_2504 purpurogallin 52.29 µM 1.66301738469978 0.0437612546694951 no 235 0.0481544778026858 312 5281571 An antioxidant.
SGTC_1270 0831-1170 17.3 µM 1.66136928711532 0.0439163775211394 no 236 0.0483196511060189 352 6764716
SGTC_1922 5578187 25 µM 1.64913786744194 0.0450815331667288 no 237 0.0495596966823111 352 1350412
SGTC_1806 st050005 60.3 µM 1.64033298587341 0.0459355806488476 no 238 0.0504679753491679 340 5194765
SGTC_3016 9080866 49.47 µM 1.636204116143 0.0463405218205704 no 239 0.0508984376355363 362 17066299
SGTC_951 1171-0579 82.7 µM 1.63078783250603 0.0468760671226215 no 240 0.0514675478650682 461 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3071 9117417 49.47 µM 1.6262425012469 0.0473293163060741 no 241 0.0519490390640933 272 45595590 YGL055W OLE1
SGTC_2763 lisinopril 49.32 µM 1.6195283278386 0.0480052553799534 no 242 0.0526668182679521 303 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1032 k061-1018 98.7 µM 1.61468971533893 0.0484971487995232 no 243 0.053188952932887 426 4005393
SGTC_376 3970-0862 59.1 µM 1.61452662172854 0.0485137988529717 no 244 0.053206623599874 370 3135186
SGTC_2780 5215298 71.43 µM 1.60236287358 0.0497685201438686 no 245 0.0545376948413012 403 2834131
SGTC_1254 0550-0035 264 µM 1.59771915193254 0.050254306556462 no 246 0.0550527472450048 401 15121435
SGTC_1946 st076057 65.1 µM 1.59757991916472 0.0502689300474535 no 247 0.0550682492065931 236 953009
SGTC_301 4119-0100 24.5 µM 1.58667619073963 0.0514247106223265 no 248 0.0562930007314728 436 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2246 7293507 91.5585 µM 1.57943396070738 0.052203988908637 no 249 0.0571182764421137 386 887656
SGTC_2030 5175110 200 µM 1.57636521378811 0.0525370083502326 no 250 0.0574708301894262 366 2831986
SGTC_2285 7945142 200 µM 1.57530919915076 0.0526519959053115 no 251 0.0575925458179729 381 2970608
SGTC_1764 st044502 93.5 µM 1.57060906427184 0.0531662097462009 no 252 0.05813674160986 392 8407
SGTC_3038 9091290 49.47 µM 1.56517959451301 0.0537651631173119 no 253 0.0587704023504849 382 25236843
SGTC_503 tyrphostin 8 294 µM 1.55829315809838 0.0545325150250916 no 254 0.05958188505575 404 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_945 3381-0768 11.3 µM 1.55407276707922 0.0550070550328419 no 255 0.0600835301452867 409 1126236 YIL048W NEO1
SGTC_1197 1601-0112 267 µM 1.54809456620511 0.0556848204088154 no 256 0.0607997650800569 423 7350313
SGTC_2754 granisetron 64.02 µM 1.54545838253733 0.0559857781409581 no 257 0.0611177139899223 428 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_694 1315-0438 43.2 µM 1.54387820691271 0.0561667916909057 no 258 0.0613089202641922 330 6793154
SGTC_1338 1486-1223 76 µM 1.54171460407198 0.0564153866090453 no 259 0.0615714807439486 417 3444526
SGTC_1739 st037196 92.5 µM 1.54153012067285 0.0564366235525966 no 260 0.0615939089910677 403 612214
SGTC_1430 4049-0248 69.1 µM 1.53995945483582 0.0566176871855047 no 261 0.0617851184108369 438 22774488
SGTC_1460 k062-0059 9.15 µM 1.53920766444916 0.0567045140828499 no 262 0.06187680354703 372 1373085
SGTC_351 caspofungin 25 nM 1.53718544050727 0.0569385883771241 no 263 0.0621239523332531 552 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3287 9117173 37.0625 µM 1.53279730580046 0.0574491355102525 no 264 0.0626629023411632 313 2789709
SGTC_1142 3253-1408 9.78 µM 1.53075174693298 0.0576883579727745 no 265 0.062915379659847 383 256655
SGTC_2086 5274770 176.623 µM 1.52920064550442 0.0578702766436398 no 266 0.0631073553168094 390 689278
SGTC_672 1441-0018 53.7 µM 1.51939755296469 0.0590304699081754 no 267 0.0643312287756752 385 251141
SGTC_1188 1403-0014 4.57 µM 1.51559907218232 0.0594848936616563 no 268 0.0648103809110403 480 9614867
SGTC_3324 9138759 60.749 µM 1.51528976150208 0.0595220178354712 no 269 0.0648495200041456 400 45595710
SGTC_3212 9128307 49.47 µM 1.51354281689192 0.0597320311284237 no 270 0.0650709168749975 393 27243542
SGTC_3018 9082602 49.47 µM 1.50027537673224 0.0613460098511125 no 271 0.0667715425022493 437 17332089
SGTC_1705 st027868 56.3335 µM 1.4960562239969 0.0618663467555574 no 272 0.067319502134484 372 292948
SGTC_3244 9134489 49.47 µM 1.49583962185207 0.0618931524021705 no 273 0.067347726725278 416 16584271
SGTC_1374 2889-5571 141 µM 1.48871878444601 0.0627794507119585 no 274 0.0682807181964899 487 2853281
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.48838987884986 0.0628206258194579 no 275 0.0683240520965901 452 165521
SGTC_2834 9001755 58.44 µM 1.48638169136179 0.063072483867461 no 276 0.0685890948855291 387 2989575
SGTC_2575 plumbagin 510 nM 1.48550848662283 0.0631822423919071 no 277 0.0687045884896904 436 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_627 1391-0720 175 µM 1.4813500041943 0.0637069898024246 no 278 0.0692566650068135 423 997839
SGTC_2862 9027634 71.43 µM 1.46932490915628 0.0652434900291476 no 279 0.0708723418547885 428 5012562
SGTC_2144 5628481 200 µM 1.4658352488473 0.0656947200170724 no 280 0.0713465878128054 395 2818399
SGTC_875 0709-0210 25.7 µM 1.46468066264067 0.0658445450762394 no 281 0.0715040315843046 490 6251364
SGTC_1687 st020778 55.3625 µM 1.46356456282858 0.0659896275424237 no 282 0.0716564805044232 610 4259299
SGTC_458 nppb 133 µM 1.46244777823428 0.066135046826283 no 283 0.0718092724152878 387 4549 A chloride channel blocker.
SGTC_443 clozapine 122 µM 1.46215779122873 0.0661728473194467 no 284 0.0718489875708559 348 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_939 1165-0479 45.3 µM 1.45904328336155 0.0665798865978251 no 285 0.0722765974962592 468 1377347
SGTC_2973 9094665 17.96 µM 1.45596107140049 0.0669846103701113 no 286 0.072701690679971 498 25237061 YIL048W NEO1
SGTC_622 1348-1566 26.3 µM 1.45231285942553 0.0674661115328065 no 287 0.0732073167400825 488 7340407
SGTC_295 k015-0027 31 µM 1.44816468349154 0.0680168443305757 no 288 0.0737854994889763 432 3887424
SGTC_229 benomyl 22.8748 µM 1.44533148210937 0.0683949849864881 no 289 0.0741823995075437 481 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_680 0417-1641 114 µM 1.44266635965494 0.0687521711628284 no 290 0.0745572400183036 419 2835990
SGTC_1358 1509-0022 2.48 µM 1.44123464798778 0.0689446456135525 no 291 0.0747592014826684 454 3258434
SGTC_864 0469-0573 172 µM 1.43879453228788 0.0692736433183362 no 292 0.0751043730045655 442 689425
SGTC_2157 5649910 96.377 µM 1.43140649457952 0.0702771395275822 no 293 0.0761568740721736 468 2858091
SGTC_403 arphamenine a 50 µM 1.43120801874782 0.0703042513195517 no 294 0.0761853030387447 478 5487158 An arginine aminopeptidase inhibitor.
SGTC_2335 9018011 154.17 µM 1.42869549380397 0.0706481578834782 no 295 0.07654588677548 518 6458208
SGTC_11 0438-0307 1.3 µM 1.42790817354552 0.07075618943972 no 296 0.0766591453563803 434 4011476
SGTC_2544 sphondin 68.51 µM 1.42574915830309 0.071053088397582 no 297 0.0769703806313933 422 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_275 trichlorophene 5.69 µM 1.42572679454067 0.0710561687696718 no 298 0.0769736095231781 649 62616
SGTC_418 lividomycin a 100 µM 1.42344840205316 0.0713705310547348 no 299 0.0773031048597498 476 72394 An antibiotic.
SGTC_937 3122-0005 46.7 µM 1.42209429878595 0.0715578692046816 no 300 0.0774994388235291 485 759535
SGTC_417 st075190 100 µM 1.42137842208901 0.0716570620151613 no 301 0.0776033880206386 483 222757
SGTC_1153 4055-0057 267 µM 1.41211066821312 0.0729507549339551 no 302 0.0789586890180711 477 882706
SGTC_3168 9103419 49.47 µM 1.39896938417693 0.0748157058670356 no 303 0.0809110820803257 347 16649256
SGTC_139 0099-0334 718.624 µM 1.39833467872541 0.074906692792025 no 304 0.0810062943451526 567 97690
SGTC_1066 ketoconazole 628 nM 1.39709728327601 0.0750843197896286 no 305 0.0811921593354255 524 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2440 5628896 157.78 µM 1.39566837935582 0.0752898370759666 no 306 0.0814071902876883 450 5522048
SGTC_1148 3909-7663 27.7 µM 1.39281392210335 0.0757016733356523 no 307 0.0818380336492781 490 4084526
SGTC_1926 methyl fluorone black 53.6 µM 1.39183061988589 0.075843939210449 no 308 0.081986847673737 449 72721 Reacts with homocysteine.
SGTC_1346 1488-2224 62.4 µM 1.39089502565823 0.0759794915610099 no 309 0.0821286307295879 495 3722427
SGTC_10 0279-0212 42.575 µM 1.39061230201302 0.0760204898798138 no 310 0.0821715119293119 619 39851 YBR002C RER2
SGTC_3080 9117754 49.47 µM 1.38685592540313 0.076566809225328 no 311 0.0827428498831133 517 9550191
SGTC_1388 3346-4487 254 µM 1.38573566583594 0.0767303141046041 no 312 0.0829138166500775 536 3345614
SGTC_2178 5812956 200 µM 1.38357932688944 0.0770457847257554 no 313 0.0832436510083702 448 5403383
SGTC_1260 0700-1617 7.75 µM 1.38020152825092 0.0775419339665612 no 314 0.0837623018000163 539 2853078
SGTC_3305 9127027 53.8275 µM 1.37943029956908 0.0776555556494485 no 315 0.0838810613006252 493 41905295
SGTC_3150 9097574 49.47 µM 1.37699917496596 0.0780145496426853 no 316 0.0842562514589115 449 17217476
SGTC_2819 7996655 46.38 µM 1.36961681016183 0.0791123902030113 no 317 0.0854032746752794 430 6456960
SGTC_3076 9116187 49.47 µM 1.36863569587882 0.0792591693025585 no 318 0.0855565900546254 453 27241210
SGTC_2815 7968870 71.43 µM 1.3685739387531 0.0792684153382215 no 319 0.0855662475202784 545 2977326 YHR190W ERG9
SGTC_2629 bisabolol 100 µM 1.36719391411708 0.0794752402937839 no 320 0.0857822662137956 525 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_565 1418-0001 44.5 µM 1.36575445783365 0.0796914071821521 no 321 0.0860080225888902 538 2862145
SGTC_1945 st075991 56.6 µM 1.35933579092971 0.080660731482367 no 322 0.0870201037616949 486 1084980
SGTC_2010 4012422 159 µM 1.3550693658603 0.0813099411682463 no 323 0.0876977288861688 520 952393
SGTC_2708 st078559 56 µM 1.35332679786343 0.0815762336379116 no 324 0.0879756258786287 391 17250902
SGTC_1279 0874-0590 65.2 µM 1.35180832760502 0.0818088160863024 no 325 0.0882183197204361 516 3523074
SGTC_2196 6573537 42.6665 µM 1.35126227501114 0.0818925764426892 no 326 0.0883057160196446 471 2903087
SGTC_1903 st060211 78.3 µM 1.35088074313834 0.0819511389020492 no 327 0.0883668188845408 526 688960
SGTC_2523 spermine 47.74 µM 1.35054657315145 0.0820024575643534 no 328 0.0884203625546034 489 1103 A DNA binding polyamine.
SGTC_623 k072-0108 16.9 µM 1.34934070647786 0.0821878444965234 no 329 0.0886137781890828 520 5382803
SGTC_851 0394-0702 453 µM 1.34758805910242 0.082457854738924 no 330 0.0888954566428436 556 762646
SGTC_2914 7968218 45.32 µM 1.34737695652971 0.0824904218989099 no 331 0.0889294291320412 470 2977111
SGTC_1562 morin hydrate 59.1 µM 1.34737422917319 0.0824908427162807 no 332 0.0889298681055571 494 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_699 0375-0592 111 µM 1.34564794361297 0.0827575242552288 no 333 0.0892080409933908 520 762578
SGTC_1962 st076595 64.5 µM 1.33901450098497 0.0837883153187736 no 334 0.0902829761080157 521 279619
SGTC_1283 0922-0125 16.4 µM 1.3357917246926 0.0842925799203272 no 335 0.090808679276317 566 3360884
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.33470205269679 0.0844635940291444 no 336 0.0909869407431534 556 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2771 fluoxetine 41.05 µM 1.33163814003656 0.0849458421061944 no 337 0.0914895628168884 496 3386 A selective serotonin reuptake inhibitor.
SGTC_1482 3346-2049 8.48 µM 1.33043397271555 0.0851359373851946 no 338 0.0916876637390803 500 3826804
SGTC_404 fumagillin 50 µM 1.32935875595866 0.0853059451971043 no 339 0.0918648190637806 552 12015870 A methionine aminopeptidase binder.
SGTC_2571 chrysanthemic acid 100 µM 1.32670215066428 0.0857270844528685 no 340 0.0923036146328495 493 2743 An insecticide.
SGTC_1571 st070080 73.4 µM 1.32315924947791 0.0862911434423409 no 341 0.0928912122544008 524 4315245
SGTC_2714 st079313 56.9 µM 1.32095124318691 0.0866440774120338 no 342 0.0932588109485504 498 2939799
SGTC_1249 0481-0015 10.2 µM 1.31475099901315 0.0876409094537763 no 343 0.0942968003066003 465 4227577
SGTC_247 mechlorethamine 29.705 µM 1.31474439462816 0.0876419758037864 no 344 0.0942979104781297 469 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2182 6325192 200 µM 1.31440140809187 0.0876973680288737 no 345 0.094355578436638 511 736248
SGTC_567 1080-0542 68.4 µM 1.31425081683137 0.0877216967230109 no 346 0.0943809062766131 479 5950415
SGTC_2366 9070441 60.58 µM 1.31370914202474 0.0878092483478611 no 347 0.094472051638563 550 6837235
SGTC_49 0717-0965 32.132 µM 1.31039595530767 0.0883461821917839 no 348 0.0950309606061319 549 5889349 YGL099W LSG1
SGTC_1618 st003135 44.5 µM 1.30965468476303 0.0884666464713718 no 349 0.0951563399609171 522 1270615
SGTC_1407 3909-7909 12.3 µM 1.30931174547978 0.0885224191092061 no 350 0.0952143863057132 561 4411780
SGTC_1958 st076513 41.9 µM 1.30775934749184 0.0887752152020554 no 351 0.0954774733655798 555 732122 YGL099W LSG1
SGTC_815 1582-0027 36.9 µM 1.29704918602244 0.0905339476231341 no 352 0.0973071318306512 549 3128206
SGTC_634 1611-4317 11.2 µM 1.29346205429648 0.0911287411818708 no 353 0.0979256499390738 595 2843522
SGTC_784 4579-0127 173 µM 1.29123529961024 0.0914994213530036 no 354 0.0983110490930027 576 1948547
SGTC_1271 0832-2808 169 µM 1.28759885412491 0.0921071686125974 no 355 0.0989428192177582 570 3663794
SGTC_2944 9067346 25.62 µM 1.28521022552545 0.0925079953955876 no 356 0.0993594156542096 550 6473075
SGTC_501 nsc-95397 161 µM 1.2842536871308 0.092668869865428 no 357 0.0995266028839596 538 262093
SGTC_954 1189-0853 2.85 µM 1.28320020399188 0.0928462882318375 no 358 0.099710972272146 572 2828194
SGTC_253 dyclonine 31.25 µM 1.28252007429956 0.0929609630323539 no 359 0.0998301337958642 606 3180 An oral anasthetic.
SGTC_830 4076-0286 57.8 µM 1.28164545718987 0.0931085836756651 no 360 0.0999835231642214 716 6866659
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.28138953169761 0.0931518123377007 no 361 0.100028439622447 608 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2948 9070189 9.45 µM 1.28065421562183 0.0932760979264909 no 362 0.100157573981153 495 6473636 YDL196W YDL196W
SGTC_1053 3366-3204 134 µM 1.27954812992168 0.0934632829392069 no 363 0.100352051127906 592 3632071 YPR165W RHO1
SGTC_1681 tripelennamine 100 µM 1.27859990591784 0.0936239734705027 no 364 0.100518991564931 491 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2060 5238662 140 µM 1.27592066180496 0.0940791132810064 no 365 0.100991783177287 541 790130
SGTC_43 0570-0105 72.5 µM 1.27552815790822 0.0941459272150875 no 366 0.101061182114332 662 1114046 YDL195W SEC31
SGTC_2612 dictamnine 15.46 µM 1.27416929025778 0.0943775106966486 no 367 0.101301713095771 560 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1061 3448-9325 110 µM 1.27272499114633 0.0946241139795699 no 368 0.101557823123929 528 723482
SGTC_446 go6976 132 µM 1.26494282159859 0.0959610397232562 no 369 0.10294591274214 533 3501 A protein kinase C inhibitor.
SGTC_1529 apigenin 74 µM 1.26479564208362 0.0959864573583113 no 370 0.10297229699666 605 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1327 1436-0082 2.18 µM 1.26405872384604 0.0961137962549435 no 371 0.103104475112621 565 15992205
SGTC_3340 9146634 11.102 µM 1.25955260725145 0.0968951522906359 no 372 0.103915400618336 575 4907387
SGTC_1672 st016598 6.51 µM 1.25892902060325 0.0970036478887789 no 373 0.104027985280217 590 4665860 YNL267W PIK1
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.25639650583801 0.0974451875739075 no 374 0.104486123933928 399 6708630 An antioxidant.
SGTC_1876 myriocin 605 nM 1.24963568518775 0.098631142784629 no 375 0.105716330586278 572 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3195 9113082 49.47 µM 1.24963304768007 0.0986316074978515 no 376 0.105716812544836 540 17018038
SGTC_1939 st074455 53.6 µM 1.24261438474495 0.0998739381035394 no 377 0.107004983281296 601 1644229
SGTC_2198 6589944 200 µM 1.24216431770017 0.0999539899114743 no 378 0.107087970979419 480 5290268
SGTC_2432 5630864 12.22 µM 1.24063574940583 0.100226220677176 no 379 0.107370169647258 576 5714970
SGTC_3176 9106582 49.47 µM 1.24002742997591 0.100334709898883 no 380 0.107482624335696 414 17018027
SGTC_3 0833-0587 95.581 µM 1.23823807350125 0.100654325014894 no 381 0.107813899013265 583 5382644
SGTC_2744 captopril 92.04 µM 1.23550997001527 0.101143047479225 no 382 0.108320384116081 509 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_131 0141-0277 33.849 µM 1.2340564410913 0.101404143067001 no 383 0.108590936666261 599 1547771
SGTC_3185 9108267 49.47 µM 1.23026155662442 0.102088126941638 no 384 0.109299587639068 597 4910486
SGTC_763 3453-1109 128 µM 1.22908799612086 0.102300325598095 no 385 0.109519407641463 614 1560353
SGTC_2782 7736369 71.43 µM 1.22614099166121 0.102834605347439 no 386 0.110072811186631 632 2950836 YOL077C BRX1
SGTC_3204 9114183 49.47 µM 1.22084396391491 0.103800026670861 no 387 0.111072552206995 569 17027248
SGTC_197 4544-0043 41.561 µM 1.21901316699335 0.104135226655213 no 388 0.111419597503839 645 896523
SGTC_3343 9148379 18.9835 µM 1.21644120264621 0.104607451291796 no 389 0.111908448178917 606 1955036
SGTC_2315 7733312 200 µM 1.21516704076735 0.104841967088485 no 390 0.112151194162 559 726316
SGTC_902 1120-0002 2.07 µM 1.21424800861631 0.105011355656165 no 391 0.112326516358643 633 3280475
SGTC_1112 tnp00069 1.16933 µM 1.21400817452268 0.105055592510958 no 392 0.112372301305431 668 145826
SGTC_1208 2323-2347 50.3 µM 1.21384457641145 0.105085775548927 no 393 0.112403540255749 627 5412760
SGTC_2257 7960413 200 µM 1.21133918147267 0.10554879271079 no 394 0.112882719014177 674 2974689 YIL048W NEO1
SGTC_1622 st003707 19.4 µM 1.21071422963948 0.105664518400082 no 395 0.113002473442277 644 10140899
SGTC_2828 7998861 71.43 µM 1.20554422238255 0.106625396416818 no 396 0.113996638489561 517 2988188
SGTC_660 4031-1742 102 µM 1.20342122626445 0.107021789718461 no 397 0.114406678961986 653 6738706
SGTC_3096 9117468 49.47 µM 1.20073942824719 0.107524037181434 no 398 0.114926147264899 495 41316311
SGTC_2411 st077133 39.94 µM 1.19622954588069 0.108372474568727 no 399 0.115803496960031 694 1403142 YNL221C POP1
SGTC_2654 protoveratrine a 100 µM 1.19563645820748 0.108484408690034 no 400 0.115919228805189 607 5702278 A heart drug and vasodilator.
SGTC_1107 amlodipine 47 µM 1.19540608753989 0.108527909232909 no 401 0.115964204198311 632 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_779 1360-0071 233 µM 1.19459955093013 0.108680305180807 no 402 0.116121762396028 682 7566
SGTC_997 3996-0078 137 µM 1.19368677694061 0.108852960370712 no 403 0.116300257440088 649 735687
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.18835191848207 0.10986601745645 no 404 0.117347395487321 668 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_818 4072-2707 53.5 µM 1.18467583708109 0.110568009357673 no 405 0.118072819792706 606 882871
SGTC_2806 7952793 58.44 µM 1.18454565422974 0.110592928146901 no 406 0.118098567617994 638 2972490
SGTC_1748 st037455 53.6035 µM 1.18448672605018 0.11060420913473 no 407 0.118110223856974 636 580690
SGTC_1284 0929-0043 16 µM 1.18385517105009 0.110725163425035 no 408 0.118235199153271 645 1239883
SGTC_48 0382-0018 55 µM 1.1833453434816 0.110822873814266 no 409 0.118336154595574 589 762596
SGTC_600 1495-0418 41.6 µM 1.18307679822637 0.110874366365601 no 410 0.118389356101189 609 5377768
SGTC_3045 9092950 49.47 µM 1.18243270493287 0.110997938702785 no 411 0.118517026336608 679 44120432
SGTC_933 2914-0560 114 µM 1.1808826147348 0.111295735110923 no 412 0.118824679327376 699 463887
SGTC_1630 st005209 31.3 µM 1.17944898968968 0.111571665463347 no 413 0.119109718709108 726 3367314
SGTC_2200 6600604 21.907 µM 1.17942022423644 0.11157720696578 no 414 0.119115442913663 673 2904777
SGTC_3199 9111318 49.47 µM 1.17740310394027 0.111966285034177 no 415 0.119517325786461 647 8548020
SGTC_70 0141-0289 43.283 µM 1.17520137287512 0.112392078552754 no 416 0.119957080562338 845 352408
SGTC_1174 0739-0097 51.1 µM 1.17376075746166 0.112671305056491 no 417 0.120245433233928 652 728447
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.17128648482484 0.113152035044483 no 418 0.12074182104036 676 442882
SGTC_1612 st002233 45.4 µM 1.16665656949886 0.114055515727373 no 419 0.121674544201019 642 1035021
SGTC_272 doxorubicin 8.13 µM 1.16438311623554 0.114501033324845 no 420 0.122134393354199 708 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2751 anetholtrithion 17.25 µM 1.16400843214727 0.114574577084118 no 421 0.122210297310497 643 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_143 4032-1194 15.74 µM 1.16323503604677 0.114726487155372 no 422 0.122367077544723 744 1806963
SGTC_2485 5633444 17.78 µM 1.15922905333133 0.115515633918166 no 423 0.123181415917124 638 5724239
SGTC_2379 9035213 200 µM 1.157717793597 0.115814339727261 no 424 0.123489610087015 710 646551
SGTC_199 4063-0024 41.6 µM 1.15670408505667 0.116015009907369 no 425 0.123696640066152 662 306215
SGTC_3117 9124945 49.47 µM 1.15540369018254 0.116272792745474 no 426 0.123962575737267 573 17592065
SGTC_426 0988-0037 14.6 µM 1.15468226138649 0.116415979820517 no 427 0.124110283097505 715 5383008
SGTC_1089 terbinafine 2.25 µM 1.15451655718419 0.116448885963025 no 428 0.124144227224673 642 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2187 6125751 200 µM 1.15411071550519 0.116529507344768 no 429 0.124227390397363 669 874498
SGTC_540 1187-0821 17.3 µM 1.15089479960661 0.117169756327533 no 430 0.124887758746559 637 847520
SGTC_959 1222-0044 107 µM 1.14831805771159 0.117684549008628 no 431 0.125418643591837 659 6083612
SGTC_2375 9072683 200 µM 1.14449379249626 0.118451524972576 no 432 0.126209455391987 736 16798029
SGTC_3237 9133362 49.47 µM 1.14411028636918 0.118528633556196 no 433 0.126288951136125 660 43845137
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.14226711206871 0.118899721158285 no 434 0.126671503612405 634 279621
SGTC_524 r073-0010 27.8 µM 1.13963939502896 0.119430178840871 no 435 0.127218282827758 662 2772106
SGTC_2505 galangin 7.89 µM 1.13729793226124 0.119904255279257 no 436 0.127706879433966 585 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_588 3970-1144 52.9 µM 1.13686002710778 0.119993065077763 no 437 0.127798402360894 690 1888707
SGTC_1096 rimcazole 32.2 µM 1.13663317212562 0.120039090859022 no 438 0.127845833360724 638 18528119 A dopamine reuptake inhibitor.
SGTC_2433 5607874 27.82 µM 1.13661979145182 0.12004180600375 no 439 0.127848631383452 654 2252428
SGTC_490 phenamil 164 µM 1.13622448854325 0.12012203857884 no 440 0.127931312079778 560 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1907 st060210 83.7 µM 1.13515348138393 0.120339605195728 no 441 0.128155508266137 748 688793
SGTC_2717 st081029 62.2815 µM 1.13237392298117 0.120905545031397 no 442 0.12873863167247 665 5292846
SGTC_3222 9128301 49.47 µM 1.12473088541085 0.122471374468546 no 443 0.130351544864847 685 4911358
SGTC_3177 9107506 49.47 µM 1.12370526828281 0.122682570690545 no 444 0.130569040356599 638 8897194
SGTC_791 1348-1292 225 µM 1.12291996163082 0.122844454512323 no 445 0.130735744415675 775 5437054
SGTC_1134 3477-0009 42.5 µM 1.11948886234292 0.123553501162554 no 446 0.131465819881827 738 3973534
SGTC_3354 9151612 71.43 µM 1.11698366335293 0.124073014927193 no 447 0.132000655160952 725 27261949
SGTC_2218 6965428 192.983 µM 1.11694382014946 0.124081289710778 no 448 0.132009173397184 695 675684
SGTC_1244 0416-0015 52.5 µM 1.11327179951527 0.124845566733581 no 449 0.132795857096557 679 96201
SGTC_3136 9095672 49.47 µM 1.11180533583101 0.125151706764345 no 450 0.13311092859126 610 17217380
SGTC_1862 st057513 3.81 µM 1.11088179235164 0.12534477520135 no 451 0.13330961685767 681 5393163
SGTC_898 1000-0849 28.3 µM 1.11058970482663 0.125405879882634 no 452 0.13337249810701 724 6751807
SGTC_1742 st038235 28.8875 µM 1.1101564562945 0.125496553720999 no 453 0.133465806384235 705 564103 YBR002C RER2
SGTC_2576 guaiol 23.12 µM 1.10895173968723 0.125748927251519 no 454 0.133725500892026 733 227829
SGTC_1917 st066507 28.5 µM 1.10363760427971 0.126866398496508 no 455 0.134875186025491 735 3156428
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.10259173878656 0.127087137688395 no 456 0.135102249711246 721 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3062 9077494 49.47 µM 1.1019698175782 0.127218526325087 no 457 0.135237396758336 682 16459633
SGTC_1524 corynanthine 62.1 µM 1.10194724336659 0.127223297186455 no 458 0.135242304006556 674 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2813 7971799 71.43 µM 1.10192543993477 0.127227905268453 no 459 0.135247043816302 681 2234054
SGTC_2346 9031566 143.75 µM 1.10147386546127 0.127323370122627 no 460 0.135345236402183 717 4771086
SGTC_2360 9040895 200 µM 1.10094834403525 0.127434530410496 no 461 0.135459569886923 643 4914414
SGTC_1497 4476-2978 41.3 µM 1.10050760690485 0.127527808825325 no 462 0.135555508549143 757 1528379
SGTC_1730 st033808 45.1 µM 1.10019180531372 0.127594674842355 no 463 0.135624280149213 788 1045166
SGTC_1121 fusaric acid 630.51 nM 1.09936763819469 0.127769294059349 no 464 0.135803870257541 712 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3028 9087778 49.47 µM 1.09880821576615 0.127887915467559 no 465 0.135925863933597 693 17217395
SGTC_2325 6158266 200 µM 1.0985057335769 0.127952086454737 no 466 0.135991857700112 679 3623240
SGTC_184 1494-0393 24.714 µM 1.09797786459429 0.128064126375951 no 467 0.136107077551959 716 3090647
SGTC_1689 st020265 53.493 µM 1.09774970885406 0.128112573402232 no 468 0.136156898597057 718 5758320 YPR016C TIF6
SGTC_2174 5790901 200 µM 1.09708065701715 0.128254714542716 no 469 0.136303067521561 685 786020
SGTC_3068 9116768 49.47 µM 1.09624275797486 0.128432881949056 no 470 0.136486276166748 640 41904888
SGTC_2908 7930301 100 µM 1.09400693265349 0.128909139293981 no 471 0.136975968844014 796 2223178
SGTC_2255 7941087 197.44 µM 1.0878871200598 0.130218991860041 no 472 0.138322471398635 806 935561
SGTC_127 0180-0333 59.125 µM 1.08030412017092 0.131854754009634 no 473 0.140003387788728 803 771601
SGTC_2810 7959871 45.46 µM 1.07796585275742 0.132361999080171 no 474 0.140524497635203 773 2974535
SGTC_2397 5161689 200 µM 1.07436124174178 0.133146586390442 no 475 0.141330403308283 747 2259942
SGTC_995 3931-2021 34.6 µM 1.07332072736229 0.133373661065323 no 476 0.141563619225821 705 730143
SGTC_608 k048-0125 159 µM 1.07109010850139 0.133861353253152 no 477 0.142064457684211 755 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_722 3534-0461 190 µM 1.06944132294176 0.134222622976096 no 478 0.142435427760917 723 658262
SGTC_1017 4239-0030 168 µM 1.0678433994803 0.134573386642606 no 479 0.14279557878778 749 1149593
SGTC_500 h-89 112 µM 1.06559784664346 0.135067375402447 no 480 0.143302736525154 793 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1347 1493-0251 600 nM 1.06361315811847 0.135505011856379 no 481 0.1437519895763 795 3986378
SGTC_890 0929-0006 47.2 µM 1.06324383048317 0.135586558060137 no 482 0.143835695147509 704 1378169
SGTC_1397 3532-0190 20.1 µM 1.062280591805 0.135799395839424 no 483 0.144054161266947 666 5322280
SGTC_2985 9022375 71.43 µM 1.0610781109294 0.136065417673342 no 484 0.144327202289563 743 4939335
SGTC_164 4100-3994 89.624 µM 1.05910766637731 0.136502104929166 no 485 0.144775374464559 809 4615967
SGTC_1448 4255-0083 152 µM 1.05835714327901 0.136668686656023 no 486 0.144946325084911 766 5399660
SGTC_107 0358-0022 2.6945 µM 1.0577445796174 0.136804750692117 no 487 0.145085952636289 603 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.05617847731888 0.137153037793858 no 488 0.145443340927648 790 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2084 5306078 60.6385 µM 1.05579652878206 0.137238071519721 no 489 0.145530592234862 726 679340
SGTC_2687 chenodiol 100 µM 1.05316940694848 0.137823926821974 no 490 0.146131678524075 702 5702181 A cholesterol synthesis inhibitor.
SGTC_858 0438-0351 2.77 µM 1.05056846799278 0.138405621922179 no 491 0.146728414737155 803 2799119
SGTC_2563 tomatine 8.54 µM 1.05051781646351 0.138416966626563 no 492 0.146740051978811 804 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2816 7982706 58.44 µM 1.04946899625943 0.138652019143243 no 493 0.146981158682899 707 2981853
SGTC_1860 st056228 74.6 µM 1.04925671417328 0.138699627037286 no 494 0.147029991191519 724 688679
SGTC_612 0302-0167 22.4 µM 1.04745996226643 0.139103025389383 no 495 0.147443744405704 833 235821
SGTC_1686 st019653 115.5 µM 1.04684127118644 0.139242115675166 no 496 0.147586396013196 759 97252
SGTC_2951 9072950 58.06 µM 1.04673422504168 0.139266190725053 no 497 0.147611087022287 818 16488155
SGTC_1398 3558-0053 112 µM 1.04007626447596 0.140769157514771 no 498 0.149152235024219 689 4532369
SGTC_96 0929-0093 37.281 µM 1.03863354069671 0.141096283172628 no 499 0.149487600290949 732 6991579
SGTC_702 1488-0190 94 µM 1.03839592130389 0.141150210804477 no 500 0.149542883832743 759 949357
SGTC_1830 st055982 50.3 µM 1.03717858927263 0.141426703032535 no 501 0.149826317228895 765 455313 An antimicrobial agent.
SGTC_733 4069-0007 56.1 µM 1.03486960738255 0.14195214911943 no 502 0.150364905004265 818 5717425 YNL287W SEC21
SGTC_2595 hexamethylquercetagetin 100 µM 1.03379287189498 0.14219762896884 no 503 0.150616502346009 715 386331
SGTC_368 fentichlor 4.58 µM 1.02869827658755 0.143363015581754 no 504 0.151810740020352 677 7329 A pesticide.
SGTC_1396 3511-0007 98.6 µM 1.02839067915008 0.143433584228919 no 505 0.151883045614654 690 X1396
SGTC_3103 9120822 49.47 µM 1.02554384610167 0.144087814253099 no 506 0.152553323948873 796 17141819
SGTC_1552 6-methylflavone 10.6 µM 1.02414413254509 0.144410218852378 no 507 0.152883600970539 742 689013
SGTC_1574 spiramycin 23.7 µM 1.02293917447615 0.144688153336872 no 508 0.153168302896515 772 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3090 9117696 49.47 µM 1.02119882450758 0.145090216416394 no 509 0.153580124583019 777 7923821
SGTC_339 3091-4833 71.4 µM 1.02018240666116 0.145325381111128 no 510 0.153820979948953 776 3240077
SGTC_1084 voriconazole 435 nM 1.01926539391624 0.145537766742905 no 511 0.154038494211309 801 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_285 1486-1325 46 µM 1.01855477787702 0.145702493140893 no 512 0.154207191318328 826 22310230
SGTC_1673 st016611 27.3 µM 1.01829390581241 0.145762996781553 no 513 0.154269151844653 808 5226799
SGTC_2570 licareol 100 µM 1.01810476660182 0.145806874095644 no 514 0.154314085174428 755 443158
SGTC_1132 3456-3614 2.5 µM 1.01726414546138 0.146001992341351 no 515 0.154513894135078 881 3125502
SGTC_874 0599-0792 117 µM 1.01677638539117 0.146115287693677 no 516 0.154629909191862 867 765305
SGTC_773 4358-1457 44.6 µM 1.0152348756431 0.146473732819615 no 517 0.154996939827503 843 1186886
SGTC_2101 5377231 179.231 µM 1.01517375847399 0.146487956465235 no 518 0.155011503560411 785 2844213
SGTC_2336 9001819 198.65 µM 1.0078090146128 0.148208723625421 no 519 0.156773078706148 810 2989602
SGTC_2113 5491891 107.031 µM 1.00585178389527 0.14866829469189 no 520 0.157243436466071 804 789979
SGTC_3179 9107801 49.47 µM 1.00533368006628 0.148790108281398 no 521 0.157368101294057 788 4818259
SGTC_1238 0333-0287 48.8 µM 1.00530532720096 0.148796776368394 no 522 0.157374925362973 779 7226
SGTC_51 1013-0126 23.419 µM 1.00298855978288 0.149342313564971 no 523 0.15793319053342 761 1627850
SGTC_2160 5660466 132.927 µM 1.00072329044101 0.149877013879827 no 524 0.158480302112782 775 2859134
SGTC_221 trifluoperazine 10.304 µM 0.99794828004379 0.150533772890848 no 525 0.159152219389924 919 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.997192481714434 0.150712978595953 no 526 0.159335544789716 829 688669
SGTC_2435 5706476 10.6 µM 0.996303053142784 0.150924050956419 no 527 0.159551460394521 847 5725375
SGTC_803 4488-1585 147 µM 0.99533363416078 0.151154330014302 no 528 0.159787012297526 815 747204
SGTC_798 1287-0182 476 µM 0.994069836049559 0.151454887721551 no 529 0.160094434647515 893 1649755
SGTC_1780 st038448 24.544 µM 0.991981379623661 0.151952436835857 no 530 0.160603304379886 809 728868 YDL195W SEC31
SGTC_1231 0242-0792 125 µM 0.991923289617207 0.151966291569674 no 531 0.160617473577025 809 3707635
SGTC_2526 patulin 37.61 µM 0.991456624664569 0.152077623755259 no 532 0.160731331175923 842 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_42 0133-0086 60.653 µM 0.99015651545666 0.152388076209891 no 533 0.16104881160695 745 162923 Model of phenazepam hydroxylation.
SGTC_3291 9121177 71.43 µM 0.990055968797244 0.152412103209625 no 534 0.161073381655782 713 17015612
SGTC_2061 5245884 80.95 µM 0.988426958206619 0.152801727920548 no 535 0.161471795086888 820 573863
SGTC_724 3910-0327 137 µM 0.985606034853942 0.153477993875891 no 536 0.162163237739915 821 2885483
SGTC_2212 7123476 200 µM 0.983855127766453 0.153898738110543 no 537 0.162593374658095 740 1085715
SGTC_1143 3454-2408 5.08 µM 0.980929577471981 0.154603451648258 no 538 0.163313735289769 789 X1143
SGTC_3249 9135183 49.47 µM 0.979393197693472 0.154974391206473 no 539 0.163692868425443 858 4902779
SGTC_2743 auranofin 4.32 µM 0.977239810129816 0.155495287950783 no 540 0.164225221721756 792 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_744 1594-0068 283 µM 0.976764901280868 0.155610321984552 no 541 0.164342778043591 866 668392
SGTC_1332 1480-0653 17.5 µM 0.976398407246534 0.155699133777664 no 542 0.16443353524702 831 5749438
SGTC_542 3381-0244 89.3 µM 0.976110185979499 0.155769001358419 no 543 0.164504932094417 900 1112843
SGTC_2006 4011487 200 µM 0.975116291093151 0.156010089483099 no 544 0.164751289246835 865 45595294
SGTC_631 k072-0230 41.5 µM 0.973154671180567 0.156486639040351 no 545 0.165238217791942 862 5773147
SGTC_9 0092-0002 10.449 µM 0.972501274513111 0.156645585685535 no 546 0.165400615567821 827 759368
SGTC_2350 9023895 38.85 µM 0.969312143128738 0.157422905186166 no 547 0.166194736207842 816 2997209
SGTC_2054 5233173 129 µM 0.967688238608778 0.157819688480182 no 548 0.16660004688454 865 6889
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.967355888953607 0.157900975377888 no 549 0.166683076685203 826 2724278 An inhibitor of dopamine biosynthesis.
SGTC_824 1304-0008 100 µM 0.966348306276827 0.158147580420976 no 550 0.166934960852053 842 768245
SGTC_602 3130-1533 38.1 µM 0.966320790722324 0.158154318374499 no 551 0.166941842868519 885 720941
SGTC_3245 9134821 49.47 µM 0.965516513501989 0.158351351400589 no 552 0.167143084444089 848 17014901
SGTC_2444 5485484 36.41 µM 0.963159512923426 0.158929700031762 no 553 0.167733739802327 873 6790631
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.96312232699529 0.158938835600684 no 554 0.167743069211289 844 6312947
SGTC_2983 9022671 12.99 µM 0.963000349712705 0.158968804509828 no 555 0.167773673884454 810 6405161
SGTC_3000 9075062 71.4286 µM 0.962581984240959 0.159071621916248 no 556 0.167878671058453 796 17057871
SGTC_2436 5633522 8.09 µM 0.961048406406405 0.159448886138325 no 557 0.168263914697524 876 5724242
SGTC_2681 menadione 3.18 µM 0.960721590238839 0.159529359436802 no 558 0.168346086261943 837 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_960 1222-0186 7.7 µM 0.959245790417599 0.159893082751428 no 559 0.168717468747655 856 3126296
SGTC_2920 7982904 15.77 µM 0.955425944634584 0.160837032887988 no 560 0.169681169442858 791 6456808
SGTC_80 0159-0065 512.242 µM 0.955210838769247 0.16089029726796 no 561 0.169735542847862 770 1548079
SGTC_1727 st034309 9.9045 µM 0.953473729517043 0.161320861099734 no 562 0.170175050232459 920 870305
SGTC_3097 9117246 49.47 µM 0.951334784664843 0.161852056282106 no 563 0.170717227191757 848 16423892
SGTC_2302 7771753 200 µM 0.949014235661994 0.162429639277464 no 564 0.171306685928766 852 2203047
SGTC_1215 3852-0577 11.2 µM 0.947747306583714 0.162745542431749 no 565 0.171629055820775 934 2884876
SGTC_1901 st060216 58.6 µM 0.947307227823858 0.162855367568906 no 566 0.171741124424328 858 688792
SGTC_1216 1165-0504 9.65 µM 0.947246651307228 0.162870488690575 no 567 0.171756554243858 872 6304004
SGTC_1619 st003326 88.7 µM 0.945552281332767 0.163293807521859 no 568 0.172188496422532 824 2849032
SGTC_1219 1469-0211 33.1 µM 0.943942141584976 0.163696744211721 no 569 0.172599607756134 862 6822282
SGTC_2519 cryptotanshinone 88.04 µM 0.943426989474501 0.163825796951523 no 570 0.172731271779875 870 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2487 5918373 44.05 µM 0.94030038701445 0.164610470270896 no 571 0.173531750569079 922 2876279
SGTC_603 3794-0023 45.9 µM 0.94001874336396 0.164681272842839 no 572 0.173603973246156 856 3802260
SGTC_975 1335-0046 28.5 µM 0.93987755263016 0.16471677429288 no 573 0.173640186381379 863 16486740
SGTC_1699 st031318 29.054 µM 0.935803431327459 0.165743319827669 no 574 0.174687202243135 901 5340658
SGTC_2886 9058944 51.95 µM 0.934913218620019 0.165968173821652 no 575 0.174916512127564 722 4949929
SGTC_2063 5246145 200 µM 0.933754613381891 0.166261114726835 no 576 0.175215243188277 895 711240
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.931564949475315 0.166815659111707 no 577 0.175780702109026 918 5393153
SGTC_1379 2144-0755 36.5 µM 0.920918326688856 0.16952895702055 no 578 0.1785465347962 948 5392327
SGTC_2126 5251174 33.877 µM 0.920517703482335 0.169631605849289 no 579 0.178651143000661 964 790722
SGTC_2630 antimycin a 100 µM 0.91959903755896 0.169867139573222 no 580 0.178891164930424 929 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1242 0402-0103 60.1 µM 0.918674435691607 0.170104406814987 no 581 0.17913294258526 821 432868
SGTC_2725 haloperidol 53.21 µM 0.914723347921948 0.171120709072662 no 582 0.1801684420237 911 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1632 st005650 90 µM 0.914689493304488 0.171129433932709 no 583 0.180177330831621 854 2759605
SGTC_1305 1181-0477 144 µM 0.913249234091499 0.17150087455568 no 584 0.180555737643596 900 6252086
SGTC_3326 9140064 16.379 µM 0.91254983183631 0.171681435018942 no 585 0.180739674905921 872 1868434
SGTC_2648 atorvastatin 78.68 µM 0.912336671523549 0.171736489468508 no 586 0.180795757732686 881 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2965 9082772 38.63 µM 0.91150279204487 0.171951969859042 no 587 0.181015257581831 931 16459634
SGTC_632 0781-2353 4.65 µM 0.910413270257235 0.172233770030302 no 588 0.181302300958665 919 6811515 YHR007C ERG11
SGTC_615 k087-0205 167 µM 0.909622155671974 0.172438573014241 no 589 0.181510905051298 851 9642773
SGTC_685 1278-0033 54.9 µM 0.909509977092543 0.172467626266423 no 590 0.181540496881391 923 3590572
SGTC_929 2805-0021 398 µM 0.909055917576347 0.172585255524402 no 591 0.181660305066749 882 3098024
SGTC_2277 7947813 106.88 µM 0.906592014097033 0.173224449277925 no 592 0.182311293189467 870 1246798
SGTC_3047 9092122 49.47 µM 0.905772351871657 0.173437422428831 no 593 0.182528178940624 857 17173831
SGTC_2764 methyldopa 94.69 µM 0.905438368991868 0.173524249099905 no 594 0.182616598275415 929 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3240 9133527 49.47 µM 0.905345279640106 0.173548454785811 no 595 0.182641247713205 874 17617455
SGTC_1851 st056236 18.9 µM 0.90487438028754 0.17367093395871 no 596 0.182765970546949 945 5393171
SGTC_3293 9120939 62.045 µM 0.904355402601836 0.173805981813006 no 597 0.182903489026017 889 934087
SGTC_457 grayanotoxin iii 135 µM 0.900923328808381 0.174700753351962 no 598 0.183814543257935 929 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1420 4'-methoxyflavone 42 µM 0.900491944539446 0.174813425520476 no 599 0.183929255139859 924 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_935 2996-0153 430 µM 0.900026874147621 0.174934947736968 no 600 0.184052974618951 910 23738523
SGTC_2358 9037157 4 µM 0.899084024412736 0.17518147745491 no 601 0.184303953395143 897 2388925
SGTC_2539 epi(13)torulosol 80 µM 0.899026584598513 0.175196503531199 no 602 0.184319250275922 886 6708597
SGTC_906 1165-0455 526 µM 0.896068733930312 0.175971372683882 no 603 0.185108027282947 887 3252859
SGTC_620 0109-0052 432 µM 0.895116078762032 0.176221401404867 no 604 0.185362519837463 940 493037
SGTC_318 1488-0629 67.2 µM 0.894687161939881 0.176334045958347 no 605 0.1854771716734 865 3662576
SGTC_936 3005-4620 401 µM 0.891640789222135 0.177135411984416 no 606 0.186292749893283 965 777207
SGTC_812 4251-0442 148 µM 0.889229322681389 0.177771390870647 no 607 0.186939923436916 935 5723007
SGTC_156 3474-0145 5.642 µM 0.88770241106126 0.178174828910989 no 608 0.187350424317267 922 2265471
SGTC_1390 3413-2614 145 µM 0.884579050796884 0.17900187388706 no 609 0.188191854793243 967 3421432
SGTC_2770 toltrazuril 17.5 µM 0.884013926569315 0.179151772680957 no 610 0.188344347520185 964 68591 Kills coccidiodes.
SGTC_726 3448-4391 34.2 µM 0.883107146606989 0.179392460354814 no 611 0.188589191617287 969 1356692
SGTC_877 0771-0151 33.1 µM 0.881450180786977 0.179832795626242 no 612 0.189037103718637 946 6166523
SGTC_865 0488-0499 301 µM 0.8786128608021 0.180588382679716 no 613 0.189805610103123 993 9634651
SGTC_489 paxilline 115 µM 0.877863857574587 0.18078817623485 no 614 0.190008802530117 897 105008 A toxic potassium channel blocker.
SGTC_88 0180-0332 8.668 µM 0.877853809756155 0.180790857390974 no 615 0.190011529248804 1004 3101745
SGTC_185 k048-0037 25.491 µM 0.87743115883696 0.180903659980129 no 616 0.190126247586675 971 6827589
SGTC_1501 4491-0275 38.4 µM 0.87683272004549 0.181063454555763 no 617 0.190288752054165 961 5104718
SGTC_1005 4092-0690 4.4 µM 0.874896184745465 0.18158115227221 no 618 0.190815197594198 890 1529343
SGTC_2194 5927483 104.545 µM 0.872672650687363 0.182176715148784 no 619 0.191420764431724 1001 760979
SGTC_2506 ethyl hematommate 54.16 µM 0.870323665350642 0.182807204130034 no 620 0.192061774801367 868 3940691 An allergen.
SGTC_2785 7756463 72.73 µM 0.86870308254202 0.183242976272503 no 621 0.192504777476323 958 2201551
SGTC_282 k297-0036 65.7 µM 0.8668995114112 0.183728714674872 no 622 0.19299853562899 942 5061378
SGTC_1184 1269-1718 139 µM 0.865697614489936 0.184052854942031 no 623 0.193328004279593 976 5403821
SGTC_811 0416-0114 265 µM 0.864722899775009 0.18431598757995 no 624 0.193595448732055 920 6612453
SGTC_2925 9010536 32.5 µM 0.864573879762327 0.184356237435672 no 625 0.19363635705993 993 2994177
SGTC_2102 5377816 72.7585 µM 0.864532526341896 0.184367407838996 no 626 0.193647710155944 997 1379702
SGTC_2170 morpholine 200 µM 0.864176345704244 0.184463636934769 no 627 0.193745512171054 951 121171 Reacts with secondary amines.
SGTC_2926 9010726 65.15 µM 0.863910624427656 0.184535447026447 no 628 0.193818494972813 936 2994293
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.863823060855661 0.184559114532905 no 629 0.193842548786866 979 688751
SGTC_1650 st011916 45.8 µM 0.860917315717612 0.185345577131529 no 630 0.194641792038158 972 242528
SGTC_1441 4106-0040 13 µM 0.859535737590428 0.185720240784073 no 631 0.195022505987012 980 2904180
SGTC_2067 5224629 34.075 µM 0.858093011143491 0.186111988061904 no 632 0.195420553090027 946 2835000
SGTC_2779 methotrexate 400 µM 0.856633381511126 0.186508845917231 no 633 0.195823765552071 1044 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_319 1348-1596 45.5 µM 0.855373355281824 0.18685185487218 no 634 0.196172244695736 991 5380505
SGTC_2319 6033012 152.6 µM 0.854418420621027 0.187112070555708 no 635 0.196436596520919 886 847246
SGTC_3208 9114115 49.47 µM 0.850349004535914 0.188223480155516 no 636 0.197565539527443 875 650895
SGTC_2155 5570423 76 µM 0.850065518634011 0.188301055251725 no 637 0.197644330439835 895 797402
SGTC_2139 5578692 56.4705 µM 0.84949356838894 0.188457627812247 no 638 0.197803353755389 941 650991 YMR113W FOL3
SGTC_1405 3909-7894 12 µM 0.848921057771111 0.188614434160043 no 639 0.197962610272021 989 7104060
SGTC_3334 9142812 21.919 µM 0.845085287420359 0.189667096375414 no 640 0.199031611087343 943 45283678
SGTC_2166 5933061 31.504 µM 0.844910344303236 0.189715192561525 no 641 0.199080449233356 1053 2877375
SGTC_2528 xanthyletin 44.79 µM 0.844396429343196 0.189856523863216 no 642 0.199223958498142 968 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_894 0960-0238 55.9 µM 0.842628724836114 0.19034315283271 no 643 0.199718060407721 994 6741907 YDL195W SEC31
SGTC_2525 harmine 47.85 µM 0.841936710676685 0.190533864944048 no 644 0.19991169014984 940 5280953 A monoamine oxidase inhibitor
SGTC_1555 citronellol 128 µM 0.841640037432992 0.19061566100851 no 645 0.199994735676878 961 8842 A terpine precursor.
SGTC_1315 1237-0019 3.69 µM 0.841292911719624 0.190711394732685 no 646 0.200091930315536 1010 825140
SGTC_1924 st058459 75.1 µM 0.841169218350522 0.19074551522934 no 647 0.200126571119326 977 688683
SGTC_3270 9137563 49.47 µM 0.841130917676547 0.190756081130952 no 648 0.20013729810124 931 17015724
SGTC_1875 nocodazole 6 µM 0.840742222186192 0.190863329803869 no 649 0.200246180734558 987 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2627 acetyl isogambogic acid 100 µM 0.840459525536654 0.190941354559801 no 650 0.200325392985005 957 6857789 A caspase activator and apoptosis inducer.
SGTC_2389 9091542 195.52 µM 0.839031368910906 0.191335827236376 no 651 0.200725853451978 960 3626624 YOL127W RPL25
SGTC_124 0136-0217 7.121 µM 0.838928226388428 0.191364335669135 no 652 0.200754793594947 1130 3976905
SGTC_2999 9069765 71.4286 µM 0.838463179705972 0.191492906174478 no 653 0.200885309358881 1022 2097066
SGTC_1309 pyrazolanthrone 13.4 µM 0.838336260757577 0.19152800438743 no 654 0.200920938116222 1035 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_561 1550-0330 72.9 µM 0.838304896350142 0.191536678519533 no 655 0.200929743334214 950 6812934
SGTC_383 2324-0395 7.37 µM 0.835669920344418 0.192266265959245 no 656 0.201670310826858 1012 3146421
SGTC_1168 k815-0004 80.5 µM 0.834759472930004 0.192518750532136 no 657 0.20192657422243 977 642433
SGTC_369 0957-0393 4.5 µM 0.832367955498902 0.193182929120824 no 658 0.202600641896909 975 6997992
SGTC_2456 5770359 74.46 µM 0.830822348626126 0.193612922327731 no 659 0.20303699775457 1028 3118787
SGTC_2106 5357045 167.29 µM 0.826362477950729 0.194856942066082 no 660 0.204299250834032 987 668842
SGTC_2778 tioconazole 65.09 nM 0.820837392863631 0.19640481259832 no 661 0.205869448131272 973 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2022 5136654 200 µM 0.820418773477599 0.196522393107982 no 662 0.205988708414611 981 1713771
SGTC_2365 9042475 200 µM 0.820326320861331 0.196548366659909 no 663 0.206015052720736 1025 6464479
SGTC_1411 3909-8223 150 µM 0.816578900400572 0.19760291347039 no 664 0.207084558509221 1078 X1411
SGTC_1770 st043884 66.3 µM 0.816467632719615 0.197634277062322 no 665 0.20711636419852 1058 670149
SGTC_2273 7815444 169.05 µM 0.814931672077555 0.198067533548168 no 666 0.207555711298916 1011 2824616
SGTC_1790 st045711 43.5 µM 0.814283736223651 0.198250472086661 no 667 0.207741212304996 1022 585119
SGTC_2369 9071472 200 µM 0.812864852322859 0.198651436536241 no 668 0.20814777401617 1016 17296037
SGTC_732 3970-1727 52.7 µM 0.809624618854234 0.199568930587042 no 669 0.209077977136384 1025 1275699
SGTC_636 0kpi-0074 126 µM 0.808627027667393 0.199851917927041 no 670 0.209364856764488 983 616434
SGTC_3129 9127257 49.47 µM 0.80798832495386 0.200033225798276 no 671 0.20954865156491 935 837894
SGTC_2628 lathosterol 100 µM 0.804131051386657 0.201130286377867 no 672 0.210660646613789 1067 6710616
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.803735902302702 0.201242875494873 no 673 0.210774757432289 1053 6708739 YPR165W RHO1
SGTC_2247 cerulenin 830 nM 0.801242718935783 0.201954124680381 no 674 0.211495572392648 1054 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3300 9124615 50.48 µM 0.800531724483063 0.202157230828601 no 675 0.211701395256773 1028 24824903
SGTC_2625 euphol 100 µM 0.799441143433008 0.202469008936008 no 676 0.212017330797687 1040 6708538 A triterpene alcohol.
SGTC_3067 9117431 49.47 µM 0.799247341344535 0.202524443642577 no 677 0.212073503074112 1022 17150885
SGTC_1044 1222-0021 1.78 µM 0.798586819524567 0.202713445944365 no 678 0.212265016395285 995 4306703
SGTC_1519 esterone 74 µM 0.797219806206759 0.203104938989756 no 679 0.212661692531197 1027 698 A steroid.
SGTC_617 3770-0098 35 µM 0.796510949141302 0.203308123105896 no 680 0.212867557023933 1005 5962639
SGTC_3180 9109287 49.47 µM 0.796136280635399 0.203415565655464 no 681 0.212976414282068 993 18891271
SGTC_1623 st003709 20.3 µM 0.796095275990059 0.203427326489311 no 682 0.21298832986057 1032 16192618
SGTC_1553 gossypol 38.6 µM 0.793508445393424 0.204170093524251 no 683 0.213740825395319 989 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2959 9079155 11 µM 0.793408681856275 0.204198771338886 no 684 0.213769877065585 1021 16189457
SGTC_3041 9091929 49.47 µM 0.793068742456881 0.204296507609033 no 685 0.21386888648611 1131 25236887
SGTC_807 1315-0151 48 µM 0.792574211184783 0.204438740444317 no 686 0.214012969397129 1108 4011080
SGTC_1167 k781-0610 148 µM 0.791552976426779 0.204732645676713 no 687 0.214310687419089 1058 4525169
SGTC_3061 glucosamine 200 µM 0.791100729438652 0.204862879895954 no 688 0.21444260678004 1031 91431 and experimental redox chemotherapeutic
SGTC_2696 st077691 74.316 µM 0.789515574412795 0.205319748061968 no 689 0.214905365330895 986 757133
SGTC_1351 1496-0003 46.5 µM 0.787427502486757 0.205922488092016 no 690 0.215515826148303 1080 3891978
SGTC_1225 1216-0074 20.6 µM 0.787258153377537 0.20597141814966 no 691 0.215565380467293 1044 4241466
SGTC_1355 1499-0035 1.68 µM 0.783446183674308 0.207074634543326 no 692 0.21668257231556 1043 1548538
SGTC_735 3076-0345 636 µM 0.78123945905157 0.20771487388057 no 693 0.217330834919343 1098 2888990
SGTC_1872 amphotericin b 148 nM 0.77959650338149 0.208192304851932 no 694 0.217814207355908 1093 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2184 6075246 200 µM 0.779583587655284 0.208196060631496 no 695 0.217818009734446 1032 2267320
SGTC_2752 diclazuril 33.15 µM 0.776341817055953 0.209140002775274 no 696 0.218773594288393 1168 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_782 0083-0095 30.5 µM 0.77508750561446 0.209505909540029 no 697 0.219143977016605 1118 3591729 An indicator and reagent.
SGTC_3290 9121031 71.43 µM 0.773703299616719 0.209910145851378 no 698 0.21955313415448 1039 17014854
SGTC_984 1492-0255 2.91 µM 0.773670057715297 0.209919859276336 no 699 0.21956296551274 1020 1585198
SGTC_1209 2323-2347 50.3 µM 0.773045840821712 0.210102307156632 no 700 0.21974762584493 1090 5412760
SGTC_2662 daunorubicin 22.37 µM 0.773004168770452 0.210114490497852 no 701 0.219759956744943 1051 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_465 cgp-37157 41 µM 0.771732867494745 0.210486370618163 no 702 0.220136329927186 998 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1698 5-fluorocytosine 1.055 µM 0.771641576457323 0.210513089863936 no 703 0.220163371177754 1098 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2252 omeprazole 400 µM 0.769410535264887 0.211166694067054 no 704 0.220824818164307 1012 4594 A proton pump inhibitor.
SGTC_1127 asiatic acid 681.4 nM 0.768966584449183 0.211296895290798 no 705 0.220956573900375 1023 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2443 5493264 126.67 µM 0.767873302721659 0.211617731743833 no 706 0.221281229865469 1085 5340055
SGTC_3147 9097027 49.47 µM 0.764325405477261 0.212660866520121 no 707 0.222336674615845 1092 25236841
SGTC_2890 9046729 58.44 µM 0.763581536031264 0.212879955398108 no 708 0.222558327937714 1021 903329
SGTC_445 e6 berbamine 66 µM 0.763498820506571 0.212904325405025 no 709 0.2225829827467 1136 6610268 A calcium/calmodulin antagonist.
SGTC_1335 1486-0900 202 µM 0.760907635348811 0.213668575654857 no 710 0.223356118853482 1136 X1335
SGTC_884 0851-0618 334 µM 0.7608702891966 0.213679602287009 no 711 0.223367273044985 1105 9642473
SGTC_867 0518-0118 155 µM 0.758667093879873 0.214330692761735 no 712 0.224025863022047 1139 6848158
SGTC_1000 4048-0884 8.67 µM 0.758309961834001 0.214436341354931 no 713 0.224132722494625 1051 13040088
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.757278540265568 0.214741631620822 no 714 0.224441502379897 1091 75037 A free radical scavenger.
SGTC_2043 5101342 149 µM 0.756395470813905 0.215003211734582 no 715 0.224706061350623 1096 678451
SGTC_497 capsazepine 133 µM 0.756287413850714 0.215035232736539 no 716 0.224738446300436 1104 2733484 A calcium channel blocker.
SGTC_2241 6772625 37.8075 µM 0.756115401586344 0.21508621161038 no 717 0.224790004278417 1102 2285411
SGTC_1855 st056195 39.6 µM 0.755394989181882 0.215299794773692 no 718 0.2250060094461 1068 4028379
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.755138476024014 0.2153758738217 no 719 0.225082949570021 1173 368090
SGTC_2460 5552655 174.22 µM 0.755107578071523 0.215385038875022 no 720 0.225092218296536 1117 5401989
SGTC_2520 obtusaquinone 4.71 µM 0.753287192710406 0.215925406875287 no 721 0.225638676625375 1147 5967872
SGTC_1345 1488-0192 31.4 µM 0.750139393073364 0.21686165923595 no 722 0.226585378098966 1146 658348
SGTC_2262 9014885 67.46 µM 0.749855577502747 0.216946189897446 no 723 0.226670845752176 1068 6457424
SGTC_1659 st012954 42.1 µM 0.748297513015035 0.217410577632155 no 724 0.22714036214052 1079 24207262
SGTC_2996 9066192 71.4286 µM 0.747249870973521 0.21772315422072 no 725 0.22745637279904 1134 6472854
SGTC_1088 bifonazole 369 nM 0.747050775552671 0.217782586035395 no 726 0.227516455915314 1068 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2740 felodipine 17.08 µM 0.746838206619774 0.217846050145635 no 727 0.227580614939568 1074 3333 L-type calcium channel blocker
SGTC_2598 perillyl alcohol 100 µM 0.746325607298431 0.217999134531262 no 728 0.227735373105704 1112 10819 An apoptosis inducer.
SGTC_3125 9127534 49.47 µM 0.74540226410863 0.218275041268192 no 729 0.228014287786393 1017 1639235
SGTC_1403 3909-7815 62.9 µM 0.744136264029802 0.218653665103805 no 730 0.228397021113836 1080 6615483
SGTC_2783 7738165 71.43 µM 0.74328156153438 0.218909495413047 no 731 0.228655616190965 1055 17201110
SGTC_235 0330-0087 5 mM 0.741956647517478 0.219306410005365 no 732 0.229056801208073 1155 46494818 YHR062C RPP1
SGTC_2964 9083345 53.42 µM 0.741717923237623 0.219377970407584 no 733 0.229129129070831 1100 17741579
SGTC_1210 3013-0140 750 nM 0.740895994427992 0.219624455807227 no 734 0.229378252191687 1153 905973
SGTC_2412 st077135 33.4 µM 0.740532552754257 0.219733497769091 no 735 0.229488458206208 1115 13258915
SGTC_963 1269-2853 151 µM 0.73996066957159 0.219905140526387 no 736 0.229661929768938 1109 3668223
SGTC_473 2-arachidonoylglycerol 10 µM 0.739216334708446 0.220128657453462 no 737 0.229887821743997 1056 5282280 An endocannabinoid.
SGTC_1049 3226-0134 66 µM 0.739013710173445 0.220189526298297 no 738 0.229949336103967 1173 5702385
SGTC_2489 cantharidin 73.42 µM 0.738557259531273 0.220326680407138 no 739 0.230087942750228 1146 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2077 5212015 200 µM 0.738216240992169 0.220429181479946 no 740 0.230191527571968 1074 780900
SGTC_468 gf-109203x 121 µM 0.736563634189072 0.220926297970334 no 741 0.230693878359552 1055 2396 A protein kinase C inhibitor.
SGTC_1169 aniline yellow 25.8 µM 0.735380110195591 0.221282704879515 no 742 0.231054015838238 1108 6051 A DNA damaging agent.
SGTC_2531 methyl deoxycholate 70.07 µM 0.734941280398769 0.221414937793289 no 743 0.231187628157981 1118 16667744 Haematoxylin.
SGTC_65 0798-0905 34.986 µM 0.733611849805256 0.221815811767276 no 744 0.23159266838988 1197 3602145
SGTC_356 1634-0012 32.5 µM 0.733602554612944 0.221818616080563 no 745 0.231595501766108 1158 735457
SGTC_1758 st042942 75.2445 µM 0.733068030779171 0.221979913325287 no 746 0.23175846872202 1129 669317
SGTC_1910 st062352 60.4 µM 0.730100064073208 0.222876740600582 no 747 0.23266451109436 1137 2245730
SGTC_727 3032-0951 202 µM 0.72999470877833 0.222908613588201 no 748 0.232696709446396 1124 3652836
SGTC_2447 5741742 33.78 µM 0.728676745396119 0.223307554529404 no 749 0.233099710454461 1146 1776504
SGTC_1176 0848-0131 83.3 µM 0.72671880868173 0.223900961740997 no 750 0.233699114476702 1211 6769040
SGTC_2402 5553605 200 µM 0.723863503764448 0.22476794553618 no 751 0.234574768964389 1170 6758546
SGTC_1754 st042065 16.137 µM 0.723734487015874 0.224807165036993 no 752 0.234614378156029 1138 1126236 YIL048W NEO1
SGTC_1280 0880-0253 10.1 µM 0.721174063240629 0.225586304467156 no 753 0.235401213736597 1133 6836607
SGTC_1421 4029-0249 71.4 µM 0.720527833940615 0.225783193909941 no 754 0.235600034316157 1228 2894095
SGTC_392 N-ethylmaleimide 8.33 µM 0.720358467216213 0.225834811664382 no 755 0.235652157437101 1124 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_130 0136-0219 337.655 µM 0.719978026834557 0.225950782489292 no 756 0.235769262299438 1117 234244
SGTC_2918 7977171 22.06 µM 0.719977603513613 0.225950911550283 no 757 0.235769392621406 1132 2236483
SGTC_1750 st081859 2.357 µM 0.719569699358542 0.226075291678587 no 758 0.235894986892611 1192 5291695
SGTC_237 nikkomycin 200 µM 0.717615699628229 0.226671651241204 no 759 0.236497137354371 1176 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2474 5321570 43.32 µM 0.715571653024041 0.227296442080414 no 760 0.237127941158161 1168 2841384
SGTC_2566 crystal violet carbinol 226 nM 0.71548454910884 0.227323088124725 no 761 0.237154842416621 1121 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3304 9125678 46.087 µM 0.714968711746981 0.227480924509128 no 762 0.237314188493422 1134 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2799 7812892 81.82 µM 0.712615712448476 0.22820167977228 no 763 0.238041793103925 1163 20205235
SGTC_259 usnic acid 108.925 µM 0.712460419741718 0.228249293132234 no 764 0.238089856360338 1238 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_4 0960-0234 25.671 µM 0.712338961948156 0.228286536465116 no 765 0.238127451381701 1160 6821112
SGTC_1018 4259-0013 28.1 µM 0.711442040465868 0.228561670610102 no 766 0.2384051775805 1148 6801262
SGTC_1319 1306-0155 43.7 µM 0.71065944514926 0.228801886838458 no 767 0.238647648213039 1213 3122360
SGTC_1801 st050089 28.441 µM 0.710368097142547 0.228891351774431 no 768 0.23873795070058 1201 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_405 ebelactone b 50 µM 0.709760426144748 0.229078013937715 no 769 0.23892635674505 1153 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_151 3013-0144 2.285 µM 0.708586117399826 0.22943897565704 no 770 0.239290676898971 1151 906558 YHR107C CDC12
SGTC_1348 1493-0373 93.8 µM 0.706018061885027 0.23022946014448 no 771 0.240088452605922 1166 3010129
SGTC_320 4092-0846 5.34 µM 0.705847552673808 0.230281999208983 no 772 0.240141473190266 1158 1359356
SGTC_2034 5197015 53.07 µM 0.703692981512715 0.230946465363362 no 773 0.240811996046389 1174 780676
SGTC_1399 3562-5772 25 µM 0.703445475515353 0.231022864284912 no 774 0.240889087424683 1125 23847490
SGTC_2967 9089538 49.85 µM 0.703211657093368 0.23109505115044 no 775 0.240961927826353 1200 728216
SGTC_2065 5221596 34.26 µM 0.703149293853642 0.231114306707466 no 776 0.240981357589457 1157 788581
SGTC_3283 9109332 35.8195 µM 0.702752886763746 0.23123672409183 no 777 0.241104881288631 1079 17027281
SGTC_1940 st075990 51.1 µM 0.702278629873174 0.231383230361289 no 778 0.241252708840574 1280 1084979
SGTC_2716 st080858 38.6235 µM 0.701759310379148 0.231543716618298 no 779 0.241414639049462 1178 5296050
SGTC_2707 st078556 66.6 µM 0.701512433202995 0.231620031280442 no 780 0.241491639091487 1146 17250899
SGTC_3277 9138724 49.47 µM 0.701240605996466 0.231704074707582 no 781 0.241576436378407 1086 15943418
SGTC_2269 7935389 174.42 µM 0.701217929711517 0.231711086520116 no 782 0.241583511041947 1119 97605
SGTC_2073 5212005 126 µM 0.70074282210161 0.231858023374638 no 783 0.241731763414853 1067 691789
SGTC_1813 st051246 8.6015 µM 0.700104846349993 0.232055412181088 no 784 0.241930914739305 1144 5291959
SGTC_1928 4'-methoxychalcone 40.3 µM 0.699732204594852 0.232170750286498 no 785 0.242047280228742 1217 641818
SGTC_452 diindolylmethane 8 µM 0.698980266114479 0.232403583423312 no 786 0.24228218175647 1132 3071 Inhibits expression of several cancer promoting factors.
SGTC_797 k781-0471 270 µM 0.696040002461087 0.233315263695992 no 787 0.243201889199213 1185 23738129
SGTC_66 0109-0187 42.4 µM 0.694506241676478 0.233791619600342 no 788 0.243682393936074 1180 759417
SGTC_3261 9137475 49.47 µM 0.694204074956159 0.233885530151711 no 789 0.243777118735643 1076 17027690
SGTC_2118 5526350 200 µM 0.694177373363879 0.233893829758398 no 790 0.243785490245736 1188 743594
SGTC_425 3825-7017 13.1 µM 0.693948278705916 0.233965045534469 no 791 0.243857322610277 1223 3397440
SGTC_2450 5739737 12.93 µM 0.692680685398202 0.23435930336008 no 792 0.24425498138787 1194 2262825
SGTC_1416 3966-0321 25.3 µM 0.692097722152092 0.234540744981212 no 793 0.244437981029831 1218 582530 YLR208W SEC13
SGTC_1667 st014849 34.6 µM 0.691727450806002 0.234656028662326 no 794 0.244554252306731 1234 5348460
SGTC_861 0443-0273 110 µM 0.690833932119415 0.23493435397745 no 795 0.244834954472948 1201 6149169
SGTC_2679 rapamycin 1 nM 0.688321517003508 0.235717931841871 no 796 0.245625167352405 1210 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2583 asiatic acid 100 µM 0.686347491518346 0.236334605169392 no 797 0.246247003824199 1237 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_444 curcumin 90.4 µM 0.686316906293043 0.236344166786924 no 798 0.246256645091688 1167 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3049 9092223 49.47 µM 0.685423297350922 0.236623622691143 no 799 0.246538423451963 1171 8623917
SGTC_584 0986-0246 15.4 µM 0.685035295538046 0.236745018026145 no 800 0.246660824371315 1304 53315 YDR232W HEM1
SGTC_3347 9188721 44.724 µM 0.684680746681332 0.236855976774235 no 801 0.246772700511104 1209 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2446 5162541 200 µM 0.683329016749168 0.237279273087252 no 802 0.247199481326911 1176 1549321
SGTC_410 α-linolenic acid 100 µM 0.683049498159041 0.237366856576258 no 803 0.247287782773203 1257 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_713 1488-1073 324 µM 0.682343913960756 0.237588021081662 no 804 0.247510755657549 1190 3312542
SGTC_1663 st014140 55.4 µM 0.6796854474589 0.238422328974482 no 805 0.248351826206716 1291 4207120
SGTC_175 3793-3120 23.7 µM 0.679072991882344 0.238614763328302 no 806 0.248545807127555 1219 5322297
SGTC_965 1291-5240 308 µM 0.678682371899056 0.238737541026531 no 807 0.248669568981648 1208 2834598
SGTC_1558 st069300 45.6 µM 0.67827956953808 0.238864184016536 no 808 0.248797224997664 1170 24208000
SGTC_1155 4088-0394 48.2 µM 0.677454426447455 0.239123727640509 no 809 0.249058838029036 1202 2326248
SGTC_466 geldanamycin 89.2 µM 0.677436307199747 0.239129428666061 no 810 0.249064584409297 1128 5288382 HSP90 inhibitor.
SGTC_3081 9117243 49.47 µM 0.675321841296563 0.239795232416057 no 811 0.249735655159417 1245 45595589
SGTC_3058 9093861 49.47 µM 0.674349409875322 0.240101771139102 no 812 0.250044598976788 1246 17217477
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.674047319713327 0.240197042231321 no 813 0.250140615017633 1231 2374 Ca(2+)-ATPase inhibitor.
SGTC_1829 berberine 14.4 µM 0.673444951822365 0.240387074306279 no 814 0.250332129398942 1256 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1301 naphtanilide LB 4.81 µM 0.67274658968441 0.240607492648592 no 815 0.250554261063104 1270 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1030 k029-0042 36.7 µM 0.671881822709731 0.240880584398225 no 816 0.250829466629064 1239 6080581
SGTC_2282 7944268 200 µM 0.670472324725741 0.241326062316859 no 817 0.251278371487817 1276 2970414
SGTC_1130 3454-2858 15.9 µM 0.670008049531092 0.241472896444133 no 818 0.251426329417722 1214 715628 YIL048W NEO1
SGTC_1638 st008370 60.6 µM 0.669950144416954 0.241491213224455 no 819 0.251444786186586 1240 24207134
SGTC_3084 9116877 49.47 µM 0.668139517630582 0.242064338551584 no 820 0.25202226933025 1168 27241325
SGTC_2939 9044578 71.43 µM 0.667574659922332 0.242243286171896 no 821 0.252202568724322 1226 2653634
SGTC_1321 1326-2144 215 µM 0.665865493820558 0.242785188557747 no 822 0.252748538948345 1220 3513030
SGTC_1480 1070-0044 41.2 µM 0.66558962200719 0.242872716990936 no 823 0.252836720800844 1242 3124987
SGTC_21 0849-0113 22.993 µM 0.66414258479257 0.243332111582361 no 824 0.253299528390751 1215 1560156
SGTC_316 k060-0003 58.6 µM 0.663941474225705 0.243395995814237 no 825 0.253363885049008 1266 6152314
SGTC_1413 3910-0535 34.4 µM 0.663151386398572 0.243647060664275 no 826 0.253616801356232 1258 2876951
SGTC_135 0933-0004 26.348 µM 0.663004699898799 0.243693688367453 no 827 0.253663772003268 1219 21230617 YGL099W LSG1
SGTC_507 nimesulide 162 µM 0.661517753560665 0.244166620548227 no 828 0.254140166510338 1295 4495 A COX2 inhibitor.
SGTC_546 peri-Naphthalide 147 µM 0.661212240722551 0.244263851985534 no 829 0.254238106156739 1205 223824 A penicillin ester.
SGTC_439 amiodarone 34.4 µM 0.659736821501863 0.244733707352599 no 830 0.254711366458677 1198 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1342 1486-1464 234 µM 0.658258108551188 0.245205099409275 no 831 0.255186145702561 1274 3253938
SGTC_2784 7567673 72.73 µM 0.657866372754729 0.245330060799073 no 832 0.255312000158893 1274 3471247
SGTC_2167 5876490 200 µM 0.657030925156999 0.24559667792079 no 833 0.255580515947088 1323 686534
SGTC_2820 7989630 71.43 µM 0.654406936210168 0.246435084859068 no 834 0.256424833425355 1161 2984098
SGTC_1395 3486-0190 4.35 µM 0.652878265756995 0.246924225939339 no 835 0.256917380844184 1305 6748079
SGTC_2371 9071574 200 µM 0.65265319304556 0.246996288136504 no 836 0.256989942268041 1231 45596039
SGTC_1602 st001878 87.6 µM 0.65252224058544 0.247038220751393 no 837 0.257032165072276 1287 595405 YLR310C CDC25
SGTC_428 3448-4153 16.5 µM 0.652001328809402 0.247205060915492 no 838 0.257200157588816 1217 3834874
SGTC_635 k038-0028 24.7 µM 0.65190636950626 0.247235481436141 no 839 0.257230787835292 1293 4035102
SGTC_2466 5983409 37.09 µM 0.649428775437647 0.248029893674251 no 840 0.258030634795021 1264 2879657
SGTC_2490 carminic acid 95.39 µM 0.649384967468483 0.248043952442095 no 841 0.258044789011578 1220 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1888 azatryptophan 97.5 µM 0.649270750851064 0.248080608614849 no 842 0.258081693933602 1237 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1819 st053448 58.6 µM 0.647066979842175 0.248788442515499 no 843 0.258794297442588 1237 2857616
SGTC_3262 9137218 49.47 µM 0.646528858892038 0.248961445924676 no 844 0.258968456853559 1144 17650664
SGTC_1654 st012436 41.8 µM 0.645082837668548 0.249426652077525 no 845 0.259436752537244 1238 4323132
SGTC_3152 9099253 49.47 µM 0.645058064363148 0.249434626035158 no 846 0.259444779210893 1277 25236131
SGTC_324 1315-0088 19.6 µM 0.644845837588829 0.249502942507534 no 847 0.25951354699282 1222 6787421
SGTC_1825 st052143 62.6 µM 0.643256589140235 0.250014842463208 no 848 0.260028809726016 1313 674173
SGTC_1275 0867-0008 21.1 µM 0.643142608138074 0.250051577366537 no 849 0.260065784666221 1272 3422836
SGTC_917 harmaline 728.087 nM 0.642953886884204 0.250112406578822 no 850 0.260127010977548 1287 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2473 5854593 8.94 µM 0.642665369802875 0.250205417459131 no 851 0.260220628132602 1251 2872951
SGTC_3024 9090631 49.47 µM 0.641214641775147 0.250673374710024 no 852 0.260691619010931 1232 25236383
SGTC_1179 1021-1431 9.29 µM 0.641050320610304 0.250726408535701 no 853 0.260744994886309 1282 2840958
SGTC_730 1436-0052 41.2 µM 0.638312634821812 0.251610856210915 no 854 0.261635094449827 1299 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3017 9080681 49.47 µM 0.637865195515693 0.251755564265606 no 855 0.261780717819627 1278 16451914
SGTC_1181 1222-0449 220 µM 0.636680942201911 0.252138780130955 no 856 0.262166344861631 1350 658318
SGTC_73 0327-0325 16.231 µM 0.636597162631094 0.252165902246732 no 857 0.262193636927102 1306 53298
SGTC_1893 st059353 36.1 µM 0.636181503060908 0.252300487241789 no 858 0.262329063873691 1244 3112488
SGTC_1788 fluconazole 20 µM 0.635082393142328 0.252656546679633 no 859 0.262687339793899 1263 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1098 clofazimine 15.1 µM 0.631740467032768 0.253740795721282 no 860 0.263778240279267 1342 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_254 nsc-64875 3.808 µM 0.631446481128802 0.253836292805176 no 861 0.263874316143026 1348 56993
SGTC_1649 st011737 51.3 µM 0.630867727787167 0.254024347602916 no 862 0.264063507352203 1282 1761035
SGTC_1124 fisetin 1.16336 µM 0.630803388578303 0.25404525790848 no 863 0.264084543745281 1302 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1993 st073995 70.8 µM 0.629394078790391 0.25450351138868 no 864 0.264545546750184 1295 3098394
SGTC_2620 irigenin 100 µM 0.628573657764841 0.254770480143434 no 865 0.264814105245763 1355 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_19 0279-0214 38.434 µM 0.628191669479887 0.254894830883809 no 866 0.264939193436899 1338 3566274 YBR002C RER2
SGTC_396 dithiazanine 1.25 µM 0.627882385789412 0.254995536965283 no 867 0.265040495335983 1267 10578 An antihelmenthic.
SGTC_2857 9024691 58.44 µM 0.627303925014666 0.255183945850627 no 868 0.265230015535617 1323 16478292
SGTC_1818 st052136 56.3 µM 0.626718472465849 0.255374706102436 no 869 0.265421896475008 1216 674169
SGTC_2298 7976326 193.81 µM 0.625467688090102 0.255782503541142 no 870 0.26583207450653 1190 2235818
SGTC_2863 9028737 58.44 µM 0.623977205704531 0.256268894060329 no 871 0.266321277458354 1312 6460917
SGTC_3299 9121982 43.1275 µM 0.620964340789018 0.257253555470586 no 872 0.267311542877746 1312 17594604 YPL160W CDC60
SGTC_1023 4482-3888 16 µM 0.620708292842444 0.257337327375025 no 873 0.267395786032543 1348 3303168
SGTC_3203 9113543 49.47 µM 0.620660618081429 0.257352926821943 no 874 0.267411473137096 1360 17018012
SGTC_176 1486-1328 72.834 µM 0.619362161017671 0.257777978069949 no 875 0.267838901339419 1293 22310231
SGTC_1712 st032288 53.4 µM 0.619048337228414 0.257880763256175 no 876 0.267942257980442 1290 2883011
SGTC_893 0958-0369 48.9 µM 0.618644693348306 0.258012998041522 no 877 0.268075226042198 1345 6819948
SGTC_2029 5175081 200 µM 0.617950388510447 0.258240536362011 no 878 0.268304021096059 1310 1380876
SGTC_1505 k297-0037 20.6 µM 0.617409297967948 0.25841793521812 no 879 0.268482395349613 1296 4089396
SGTC_26 0302-0163 425.158 µM 0.61719329416243 0.258488770620709 no 880 0.268553619150608 1321 3100915
SGTC_3226 9131256 49.47 µM 0.617169990600523 0.258496413296274 no 881 0.268561303695057 1222 17178073
SGTC_1286 0929-0070 131 µM 0.616130850160602 0.258837330485368 no 882 0.268904081253372 1382 1420408
SGTC_2802 7925815 54.55 µM 0.615665819737207 0.258989971192106 no 883 0.269057550302417 1308 1262923
SGTC_1636 st007707 68.9 µM 0.615178248179756 0.259150060739557 no 884 0.26921850555384 1342 403051
SGTC_1570 verbenone 133 µM 0.614641757907137 0.259326271383231 no 885 0.269395665457303 1345 29025 A natural terpanoid with antifungal properties.
SGTC_762 1165-0429 115 µM 0.614593252842116 0.259342205960358 no 886 0.269411685688185 1382 5967793
SGTC_1325 1431-0015 227 µM 0.613880810485738 0.259576311287489 no 887 0.269647045838058 1251 1103340
SGTC_1797 st048695 56.8 µM 0.612618154066435 0.259991482347996 no 888 0.270064425810393 1291 592262 YIL048W NEO1
SGTC_1081 sertraline 6 µM 0.608587216435018 0.261319173256533 no 889 0.271399039974402 1330 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2390 9097792 176.6 µM 0.607537371378346 0.261665536977156 no 890 0.271747174658581 1287 4497149
SGTC_2457 5731572 11.68 µM 0.606926289593769 0.261867252821232 no 891 0.271949915194403 1367 2865357
SGTC_912 3474-0017 2.18 µM 0.606699621374759 0.261942095436586 no 892 0.272025136750644 1411 3360550
SGTC_2685 mycophenolic acid 18.85 µM 0.606664988761852 0.261953531597594 no 893 0.272036630755296 1313 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3225 9130819 49.47 µM 0.606304547525639 0.262072569403466 no 894 0.272156269712005 1360 4547121
SGTC_2515 chrysin 20.77 µM 0.605558821305405 0.262318937796269 no 895 0.2724038768539 1362 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_646 4092-0839 27.3 µM 0.605465341616135 0.262349829399613 no 896 0.272434923264834 1402 877796
SGTC_2738 aclarubicin 5.55 µM 0.605154568038244 0.262452542041666 no 897 0.272538149805316 1296 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3001 9076041 71.4286 µM 0.604985429323055 0.262508452112047 no 898 0.272594339074146 1332 16004211
SGTC_1352 1496-0991 99 µM 0.604824346338094 0.262561704967966 no 899 0.272647857508996 1327 3000039
SGTC_2204 7233102 200 µM 0.604791436217611 0.262572585493093 no 900 0.272658792254693 1291 2172480
SGTC_103 0844-0104 51.839 µM 0.604626180882719 0.262627224601081 no 901 0.272713703428417 1361 5375804
SGTC_390 dec-rvkr-cmk 16.7 µM 0.600981480104037 0.263833765645031 no 902 0.273926160764642 1384 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1201 1889-3372 45.9 µM 0.600913047793319 0.263856446464613 no 903 0.273948951127197 1279 5392199
SGTC_2176 5809774 33.9695 µM 0.600202989854639 0.26409184272267 no 904 0.274185480655812 1330 2870539
SGTC_3345 9148410 3.559 µM 0.599724787606849 0.264250435154251 no 905 0.274344832861467 1320 4903596
SGTC_2938 9059746 27.26 µM 0.59897785277417 0.264498247869285 no 906 0.274593826759931 1338 6471769
SGTC_2902 5787006 60.46 µM 0.598933455489365 0.264512981406585 no 907 0.27460863029256 1334 591003
SGTC_2675 theaflavin digallate 100 µM 0.597557057007771 0.264969955553553 no 908 0.27506776254193 1347 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2103 5378138 10 µM 0.597361262005003 0.265034993472244 no 909 0.275133105583159 1375 244142
SGTC_2311 7694451 200 µM 0.596167939492904 0.265431558899942 no 910 0.275531520575688 1370 2163142
SGTC_2163 5671233 125 µM 0.595445309761501 0.265671849796107 no 911 0.275772923071783 1445 701023
SGTC_2848 9016370 25.97 µM 0.595259146149861 0.265733771313852 no 912 0.275835129929586 1363 7894410
SGTC_1224 0823-0416 294 µM 0.595153466882161 0.265768925480787 no 913 0.275870445887368 1406 3598164
SGTC_1161 k007-0610 110 µM 0.594827940264818 0.265877226595345 no 914 0.275979244515721 1403 5843850
SGTC_2555 cholic acid 100 µM 0.594168152041893 0.266096803492164 no 915 0.276199825830365 1339 6708657 Influences liver metabolism.
SGTC_2536 dehydroabietamide 32.04 µM 0.594141148016508 0.266105792362088 no 916 0.276208855696437 1428 3983547
SGTC_2989 9073649 71.4286 µM 0.593858073134236 0.266200029170904 no 917 0.276303521720392 1339 21367202
SGTC_1026 k007-1105 30.6 µM 0.591006768629703 0.267150181513183 no 918 0.277257942888197 1348 7066794
SGTC_3033 9090887 49.47 µM 0.589709293152913 0.267583110846003 no 919 0.277692781881957 1312 19325384
SGTC_1879 gemcitabine 100 µM 0.589366385600179 0.267697588053786 no 920 0.277807760354648 1353 60750 A nucleoside analog which inhibits DNA replication.
SGTC_655 k060-0012 42 µM 0.589250824263917 0.267736172930296 no 921 0.277846513835857 1315 5994525
SGTC_1760 st045453 10.4495 µM 0.589174205420721 0.267761756808333 no 922 0.277872209411267 1375 3323419 YIL048W NEO1
SGTC_1299 1079-1439 3.74 µM 0.588891451350543 0.267856182175059 no 923 0.277967046364754 1320 323161
SGTC_2860 9025725 38.96 µM 0.58881911147024 0.267880342681535 no 924 0.277991312014687 1305 40546248
SGTC_3142 9086498 49.47 µM 0.587547454873234 0.268305237332017 no 925 0.278418044522689 1295 25236367
SGTC_2871 9038510 12.99 µM 0.586791029652341 0.268558140034555 no 926 0.278672031062108 1434 4945164
SGTC_227 fluconazole 33.516 µM 0.58628239513614 0.268728263905717 no 927 0.278842879787482 1308 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2341 7987486 176.74 µM 0.584834106170804 0.269212972002451 no 928 0.279329634483372 1395 1258686
SGTC_2001 4023502 57.655 µM 0.584445626117613 0.269343061652586 no 929 0.279460268729173 1393 108941 YCR052W RSC6
SGTC_1849 st056239 19.2 µM 0.584433994458092 0.269346957212455 no 930 0.279464180566508 1264 5393181
SGTC_415 dibenzyl ketone 100 µM 0.584282421622514 0.269397723063533 no 931 0.279515158378589 1443 7593
SGTC_435 c-PAF 6.7 µM 0.581026364447993 0.270489421870394 no 932 0.280611342438042 1332 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2976 9009005 19.48 µM 0.579180001348903 0.271109455612971 no 933 0.281233861725628 1433 2993148
SGTC_629 3448-6466 76.7 µM 0.578778512589782 0.271244374737094 no 934 0.281369315781006 1359 573744
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.578488372880459 0.271341896167559 no 935 0.281467222550796 1333 5355888
SGTC_1534 6-azauridine 81.6 µM 0.578478751009532 0.271345130559225 no 936 0.28147046970369 1371 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2611 pyromycin 23.93 µM 0.578287710698011 0.271409352732474 no 937 0.281534945012785 1335 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1503 4585-0012 61.3 µM 0.577514983030951 0.271669198449292 no 938 0.281795810042715 1414 2922052
SGTC_572 0960-0087 17.7 µM 0.575063893476864 0.272494246785232 no 939 0.282624042998117 1331 6796365
SGTC_1199 1638-0010 4.46 µM 0.573875334216102 0.272894768905354 no 940 0.283026082724712 1353 3111136
SGTC_2861 9024595 19.48 µM 0.573680683224774 0.272960390440341 no 941 0.283091951139132 1335 16482810
SGTC_1440 4100-1550 40 µM 0.573577303883227 0.272995245285852 no 942 0.283126936912578 1382 742806
SGTC_366 0181-0206 4.31 µM 0.571465352528004 0.273707782520758 no 943 0.283842120030035 1456 274874
SGTC_1935 st074532 41.6 µM 0.571058541452037 0.273845139402636 no 944 0.283979980246408 1447 2829742
SGTC_1483 3453-0561 55.9 µM 0.570892042761141 0.273901366335404 no 945 0.284036412593315 1400 4546991
SGTC_1715 st032160 10.2275 µM 0.569947547866685 0.274220432079282 no 946 0.284356637105912 1365 5289825
SGTC_731 3966-0296 387 µM 0.568748484783802 0.274625759357944 no 947 0.284763419592265 1405 660956
SGTC_256 clotrimazole 625 nM 0.568564806546437 0.274687875426346 no 948 0.284825757006333 1368 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_896 0964-0007 44.5 µM 0.568275947996183 0.274785575250171 no 949 0.284923804081737 1368 6756758
SGTC_2275 7947463 200 µM 0.568270844182067 0.274787301653026 no 950 0.284925536610869 1349 1225414
SGTC_41 0478-0632 82.643 µM 0.568211783561929 0.274807279733334 no 951 0.284945585560155 1387 3750424
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.568126190458088 0.274836234067809 no 952 0.284974642524323 1419 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3100 9120536 49.47 µM 0.568020656146576 0.274871936160446 no 953 0.285010471032238 1329 16421196
SGTC_740 k014-0057 261 µM 0.56740581524081 0.275079981316463 no 954 0.285219249941507 1455 4012779
SGTC_1103 duloxetine 36.1 µM 0.567161441175693 0.275162692273883 no 955 0.285302251236734 1488 60835 A selective serotonin reuptake inhibitor.
SGTC_609 0986-0026 86.3 µM 0.565249195462872 0.275810334332092 no 956 0.285952139683809 1429 2848610
SGTC_2295 7971645 200 µM 0.561848191184327 0.276964038776898 no 957 0.287109727460482 1459 2978226 YKL099C UTP11
SGTC_1716 st033144 30.6155 µM 0.558556373894579 0.278082949704789 no 958 0.288232260347581 1439 674617
SGTC_2742 clothiapine 36.27 µM 0.555836314385854 0.2790091770822 no 959 0.289161378960312 1418 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2331 7980721 200 µM 0.554817560662339 0.279356466184232 no 960 0.289509727229425 1438 2981221
SGTC_2488 5268135 45.7 µM 0.552505570474882 0.280145392687734 no 961 0.290301009481353 1474 1270356 YLR208W SEC13
SGTC_2745 rifampicin 24.3 µM 0.551137539901258 0.280612717223609 no 962 0.290769696564309 1435 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_967 1306-0166 352 µM 0.550737776739475 0.280749349044914 no 963 0.290906722139234 1446 4437607
SGTC_1207 2099-0101 141 µM 0.547591036746836 0.281825969782177 no 964 0.291986372663132 1442 5837381
SGTC_2650 prasterone 100 µM 0.546627602371717 0.282155995111502 no 965 0.29231730088865 1397 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2363 9053361 176 µM 0.544975087672849 0.282722498379959 no 966 0.292885325813426 1525 6469797 YMR079W SEC14
SGTC_2382 9035899 200 µM 0.544852504870465 0.282764543103472 no 967 0.292927482052033 1427 6462679
SGTC_1651 st011928 86.1 µM 0.54376095691349 0.283139065971245 no 968 0.293302989623614 1412 720198
SGTC_3284 9108171 64.8615 µM 0.543549458960841 0.283211660910041 no 969 0.293375773633832 1437 8687505
SGTC_1276 0871-0068 94.2 µM 0.542315639044082 0.283635337366188 no 970 0.293800541917329 1458 3414906
SGTC_2052 5265182 7.135 µM 0.541305446329176 0.283982449281216 no 971 0.294148533573562 1505 1239884
SGTC_2884 9058502 51.95 µM 0.539144400383932 0.284725687163873 no 972 0.294893610494383 1404 6471554
SGTC_2221 6807166 181.081 µM 0.538175941955481 0.285059065300012 no 973 0.295227793781851 1427 674925
SGTC_1035 k081-0041 55.2 µM 0.535423001923436 0.286007741071099 no 974 0.296178693993965 1417 731709
SGTC_1578 josamycin 24.2 µM 0.535112481829528 0.286114841817667 no 975 0.296286039675985 1366 5282165 A P450 substrate.
SGTC_517 1365-0151 113 µM 0.534470029774247 0.286336488897015 no 976 0.296508189670064 1447 768657
SGTC_857 0438-0306 1.35 µM 0.534085887116772 0.286469057712702 no 977 0.296641056717035 1449 4686136
SGTC_2879 9041815 71.43 µM 0.532617606210281 0.286976034199369 no 978 0.297149156018474 1395 4942971
SGTC_1729 st035615 45.989 µM 0.531441532932241 0.287382421857465 no 979 0.297556423483488 1413 17385451
SGTC_1633 st005664 67.9 µM 0.529755524611711 0.287965490057086 no 980 0.298140722610773 1422 2063822
SGTC_2324 6149169 200 µM 0.5281055409782 0.288536640078824 no 981 0.298713042612539 1409 2888231
SGTC_1694 st024011 44.9 µM 0.525800728205271 0.28933535483905 no 982 0.299513334267176 1476 2787533
SGTC_2854 9024559 71.43 µM 0.525060780439774 0.289591998060332 no 983 0.29977046954211 1404 3163529
SGTC_402 epigallocatechin gallate 10 µM 0.524849629203737 0.289665253276078 no 984 0.299843863903848 1431 65064 An antioxidant.
SGTC_322 k048-0136 19.3 µM 0.524787303723748 0.289686877670005 no 985 0.299865529261993 1435 6823282
SGTC_2772 vinpocetine 57.06 µM 0.524149243795088 0.289908301953763 no 986 0.300087370100351 1485 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_966 1300-0360 30.2 µM 0.523331422983579 0.290192224200469 no 987 0.30037181874715 1451 70588
SGTC_934 2950-0684 338 µM 0.520068204407742 0.291326408340722 no 988 0.301508019243039 1560 1121253
SGTC_1140 3229-1848 2.98 µM 0.520055010580574 0.291330998263856 no 989 0.301512617045716 1478 2849525
SGTC_2935 9038016 29.96 µM 0.518635969098456 0.291824857166761 no 990 0.302007310579267 1437 6463195
SGTC_3276 9139060 49.47 µM 0.518206103889785 0.29197453702615 no 991 0.302157238247642 1489 4870619
SGTC_1656 st012921 11 µM 0.516181604514752 0.292679951608399 no 992 0.302863788499195 1482 6732821
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.514598783401436 0.293232019039457 no 993 0.303416707718012 1443 17037758
SGTC_1753 st043925 64 µM 0.513083265097798 0.293761064074329 no 994 0.303946538603324 1498 670181
SGTC_870 0573-2213 57.6 µM 0.51299298435129 0.293792593682349 no 995 0.303978114107275 1423 3916321
SGTC_3190 9110366 49.47 µM 0.512535941667264 0.293952235088843 no 996 0.304137986275953 1513 17123768
SGTC_1884 5633444 25 µM 0.511148009624766 0.294437274499354 no 997 0.304623710237738 1480 5724239
SGTC_2128 5255449 168.493 µM 0.510981495932585 0.294495490707701 no 998 0.304682006933573 1422 736008
SGTC_1004 4084-0029 199 µM 0.510754477788748 0.294574868927638 no 999 0.304761494320836 1524 716894 YLR208W SEC13
SGTC_2380 9035439 200 µM 0.509492404242391 0.295016340196326 no 1000 0.305203560578113 1543 6462575
SGTC_988 1497-1057 103 µM 0.509446074228194 0.295032552157896 no 1001 0.305219793997131 1522 3533044
SGTC_1078 idebenone 36.1 µM 0.507830375977693 0.295598179492225 no 1002 0.305786152604568 1480 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_398 bronopol 33.3 µM 0.50770676593454 0.295641473699722 no 1003 0.305829501395088 1489 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3207 9114163 49.47 µM 0.506689113135723 0.295998015581662 no 1004 0.306186485278652 1636 849233
SGTC_381 3461-2219 42.7 µM 0.505970204770307 0.296250009146009 no 1005 0.306438783168348 1545 2883159
SGTC_2463 5473429 200 µM 0.505425913260185 0.296440860995278 no 1006 0.306629861061352 1485 5399405
SGTC_663 1486-0733 13.9 µM 0.505386319095945 0.296454746598794 no 1007 0.306643762961545 1461 722445 YPR165W RHO1
SGTC_1968 st069590 43.6 µM 0.504697720647883 0.296696284517187 no 1008 0.306885581119019 1502 6384066
SGTC_1372 2752-0194 270 µM 0.503860861225691 0.296989948805143 no 1009 0.307179577878591 1417 823334
SGTC_3336 9143619 71.43 µM 0.502875630776801 0.297335848621307 no 1010 0.307525857711262 1504 45595730
SGTC_2 0422-0095 29 µM 0.502270810457747 0.297548283209922 no 1011 0.30773851947821 1378 6790840
SGTC_505 gw-5074 63.9 µM 0.500591618221171 0.2981384386554 no 1012 0.308329281279524 1544 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1735 st034310 56.75 µM 0.500109468033442 0.298307989776873 no 1013 0.308498999881802 1593 871153
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.499817092545575 0.298410826817528 no 1014 0.308601937043026 1410 88881 An O-methylated flavonoid and antioxidant.
SGTC_471 1-acyl-paf 4 µM 0.498299534155504 0.298944855649247 no 1015 0.309136468079247 1402 16759367
SGTC_1976 st070609 63.5 µM 0.498190825443838 0.298983126903299 no 1016 0.309174774183822 1448 682556
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.498114347098804 0.299010052685662 no 1017 0.309201724394005 1462 1241132 A phosphatase inhibitor.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.496829819990533 0.299462461475589 no 1018 0.309654532350534 1513 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3214 9129694 49.47 µM 0.494897486297418 0.300143610791952 no 1019 0.310336242582047 1578 17158655
SGTC_1796 st049173 110.4 µM 0.49313066906208 0.300767027896993 no 1020 0.310960130946215 1475 94134
SGTC_2721 ifenprodil 61.44 µM 0.491891370871446 0.301204659526538 no 1021 0.311398069402181 1557 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_38 0929-0051 58.268 µM 0.491437921922227 0.301364856965722 no 1022 0.311558374216224 1592 1379719
SGTC_1798 st045719 60.953 µM 0.490838917719826 0.301576535908578 no 1023 0.311770190983475 1436 3980186
SGTC_2425 5628681 7.85 µM 0.490151287967798 0.301819616194705 no 1024 0.31201342384706 1564 5714958
SGTC_710 3448-4187 58 µM 0.487498994506766 0.302758037918704 no 1025 0.312952377608874 1517 3946412
SGTC_560 2332-1943 155 µM 0.485702490069752 0.303394409876822 no 1026 0.313589058961669 1515 21177716
SGTC_2293 7624732 200 µM 0.484596028915733 0.303786646429301 no 1027 0.313981465573627 1433 894453
SGTC_1998 st075797 76.8 µM 0.483481348056999 0.304182025450848 no 1028 0.314377000114761 1513 24208315
SGTC_1509 1326-1131 80 µM 0.482949542873315 0.304370738313427 no 1029 0.314565781584361 1509 768313
SGTC_268 camptothecin 39.6153 µM 0.482619694455117 0.304487812320029 no 1030 0.314682896329214 1518 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3105 9121040 49.47 µM 0.48242318796614 0.304557568432559 no 1031 0.314752676050984 1435 41448907
SGTC_1832 st054113 55 µM 0.48135783255087 0.304935873280015 no 1032 0.315131100309887 1523 1251267
SGTC_249 wiskostatin 11.211 µM 0.48060108003673 0.305204720805755 no 1033 0.315400023849529 1544 2775510 A n-wasp and actin depolymerizer.
SGTC_2112 5488546 200 µM 0.479649434438838 0.30554295621352 no 1034 0.315738344461089 1476 600757
SGTC_1933 st074711 15.9 µM 0.477448742532814 0.306325765217854 no 1035 0.316521306167701 1475 17250958
SGTC_559 1550-0661 158 µM 0.47738172417514 0.306349618245926 no 1036 0.316545162874639 1577 5830875
SGTC_2829 7992743 58.44 µM 0.475990835306333 0.306844845526525 no 1037 0.317040453541281 1624 16462845
SGTC_717 1532-0246 73.2 µM 0.475908367537243 0.306874219337764 no 1038 0.317069830333853 1482 9561992
SGTC_106 0092-0003 11.579 µM 0.475863745616765 0.306890113529131 no 1039 0.317085726102105 1598 1072148
SGTC_223 busulfan 5 mM 0.475556823946775 0.30699944792165 no 1040 0.317195070650874 1552 2478 A DNA alkylator.
SGTC_863 0466-0191 129 µM 0.474978157333958 0.307205632422534 no 1041 0.317401271022874 1552 765160 YPR165W RHO1
SGTC_1911 st060208 74.3 µM 0.474188139787122 0.30748722172466 no 1042 0.317682875076905 1603 688783
SGTC_323 4013-0906 34.3 µM 0.474120464974159 0.307511348624652 no 1043 0.317707002869293 1592 2910086
SGTC_2312 7706453 155.7 µM 0.47406747452191 0.307530240951465 no 1044 0.317725895853964 1507 976098
SGTC_1205 4161-2785 76 µM 0.473848773970304 0.307608218178229 no 1045 0.317803875415703 1447 3498106
SGTC_728 3030-5151 22.5 µM 0.472724840057916 0.308009091553998 no 1046 0.31820475113688 1548 3125388
SGTC_701 4424-0219 185 µM 0.470166079204614 0.308922578779177 no 1047 0.319118183400365 1625 2911779
SGTC_2955 9076254 12.21 µM 0.469712427309211 0.309084657842329 no 1048 0.319280243971778 1582 16459619
SGTC_1556 plumbagin 1.48 µM 0.469631612251496 0.309113535047299 no 1049 0.319309117606042 1494 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.467027959184635 0.310044514559902 no 1050 0.320239937324659 1501 229346 A bile salt which induces apoptosis.
SGTC_2130 NSC 7 2.4545 µM 0.466822876018994 0.310117897331652 no 1051 0.320313303820798 1639 21448
SGTC_2026 5148700 152 µM 0.465819776070507 0.310476935051519 no 1052 0.320672254170394 1505 79838
SGTC_1554 st069299 38.7 µM 0.464682620899032 0.31088417337969 no 1053 0.321079377859879 1527 24207999
SGTC_817 1391-0715 46 µM 0.46434639864644 0.311004625797649 no 1054 0.321199793208567 1514 1353946
SGTC_1771 st048882 4.1505 µM 0.463454022024948 0.311324420003693 no 1055 0.321519482002316 1465 4580403
SGTC_1891 st059073 26.2 µM 0.462293110945912 0.311740660024948 no 1056 0.32193556961362 1672 688754
SGTC_3265 9137266 49.47 µM 0.462199789830114 0.311774130393093 no 1057 0.321969026979895 1648 17224265
SGTC_1204 4049-0315 18.3 µM 0.460914226749152 0.312235366060524 no 1058 0.322430072174082 1650 588402
SGTC_1334 1486-0610 236 µM 0.460258362451448 0.312470791210535 no 1059 0.322665391985727 1561 3742339
SGTC_2638 epoxomicin 18 µM 0.45854306659792 0.313086865369787 no 1060 0.323281164571168 1642 9915668 A protesome inhibitor.
SGTC_695 3505-6186 243 µM 0.458137160934347 0.313232728928427 no 1061 0.323426951244013 1587 1819379
SGTC_515 4092-1064 102 µM 0.456844687447628 0.313697378204335 no 1062 0.323891341622707 1672 717353
SGTC_1464 k208-0027 110 µM 0.455636464081324 0.314132006674849 no 1063 0.32432570869027 1628 X1464
SGTC_464 bw-b 70c 158 µM 0.45547490272914 0.314190143936276 no 1064 0.324383809577577 1610 5353454
SGTC_283 0987-0079 11.7 µM 0.453860100824481 0.314771477634837 no 1065 0.324964761312221 1600 411556
SGTC_943 3253-1379 105 µM 0.45039478548123 0.316020551109211 no 1066 0.326212902123277 1622 668464
SGTC_2348 9022543 33.42 µM 0.449165520697299 0.316464145914297 no 1067 0.326656129035682 1580 3162678 YDL140C RPO21
SGTC_3011 9081274 71.4286 µM 0.448510341252157 0.316700683168758 no 1068 0.32689246228173 1544 6625322
SGTC_2238 6671620 73.2395 µM 0.44817173132148 0.316822959775717 no 1069 0.327014631292287 1474 729941
SGTC_1074 carmofur 3.8 µM 0.447917624145834 0.316914734445284 no 1070 0.327106324249827 1562 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1547 harmine 94.2 µM 0.447669455717504 0.317004375120417 no 1071 0.327195884322187 1555 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2225 6654152 15.4 µM 0.447300116351654 0.317137803718742 no 1072 0.32732919149795 1612 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_105 0111-0055 734.78 µM 0.447276575334327 0.317146309020362 no 1073 0.327337689000923 1550 5179370
SGTC_1579 chlormadinone acetate 49.4 µM 0.446608485203914 0.317387728310809 no 1074 0.327578883999592 1669 45114258 A steroidal progestin.
SGTC_72 0744-0168 198.391 µM 0.446080365025554 0.317578623426685 no 1075 0.327769597757245 1614 677577
SGTC_2378 9074213 121.43 µM 0.445616452677694 0.317746349912542 no 1076 0.327937161978235 1527 657714
SGTC_1522 st012842 45.6 µM 0.444425148502755 0.318177234613005 no 1077 0.328367617324936 1462 3491067 YOR116C RPO31
SGTC_2866 9034245 58.44 µM 0.444161484989014 0.318272632779794 no 1078 0.328462918001491 1669 6462273
SGTC_3314 9135860 59.4275 µM 0.442931253456925 0.318717911766295 no 1079 0.328907730300604 1606 25252478
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.441979620012401 0.319062532600981 no 1080 0.329251976794598 1618 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_136 0097-0015 404.482 µM 0.441621228012178 0.319192359856782 no 1081 0.329381660054506 1591 4861337
SGTC_2129 girgensonine 121.053 µM 0.441155462832416 0.319361116110526 no 1082 0.329550226705225 1642 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3320 9137005 35.139 µM 0.441073383171186 0.319390859130907 no 1083 0.329579936023808 1559 4908713
SGTC_940 3232-1287 54.8 µM 0.440593990750534 0.319564598684149 no 1084 0.329753477009646 1569 1585493 YIL048W NEO1
SGTC_2074 5212007 75.395 µM 0.440000431074272 0.319779769176552 no 1085 0.329968397553578 1664 758611
SGTC_207 4185-0010 4.486 µM 0.439721805251748 0.319880794361929 no 1086 0.330069303847813 1598 3761753
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.438563815380054 0.320300805718741 no 1087 0.330488810393566 1657 94937 An inhibitor of serotonin biosynthesis.
SGTC_2356 9061756 188.97 µM 0.437977498949777 0.320513554822158 no 1088 0.330701297327266 1635 20104043
SGTC_657 3534-0529 86.7 µM 0.43530286127882 0.321484813654902 no 1089 0.331671304147027 1669 1049549
SGTC_3213 9129884 49.47 µM 0.43492680724383 0.321621470751366 no 1090 0.3318077778366 1448 17190742
SGTC_2524 avocatin b 10.57 µM 0.43487392680306 0.321640689307761 no 1091 0.331826970456653 1656 6710748
SGTC_204 PMA1.184 62.41 µM 0.434571242404103 0.321750704329566 no 1092 0.331936836328616 1567 2252213 YGL008C PMA1
SGTC_580 1123-0028 41 µM 0.43428363839483 0.321855252647428 no 1093 0.332041241836307 1596 1677248 YPR107C YTH1
SGTC_1786 berberine 21.6 µM 0.432761648573676 0.322408753147666 no 1094 0.332593968885532 1515 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2522 biochanin a 4.94 µM 0.432608530671714 0.322464459208278 no 1095 0.332649595485208 1625 5280373 A possible chelator.
SGTC_2975 9084847 53.72 µM 0.432092210988967 0.322652331648292 no 1096 0.332837197757708 1569 27211724
SGTC_669 0108-0021 26.2 µM 0.430509010175041 0.323228690619173 no 1097 0.333412706939118 1842 17201
SGTC_203 k066-0004 30.888 µM 0.430014036540135 0.323408971302841 no 1098 0.333592715330315 1645 6795412
SGTC_778 3456-2434 196 µM 0.42936118105231 0.323646819570187 no 1099 0.333830199633992 1737 5539063
SGTC_1834 st055981 52.8 µM 0.429298076574923 0.32366981360969 no 1100 0.333853158202576 1673 471719 YDL150W RPC53
SGTC_3026 9090633 49.47 µM 0.429272759613549 0.323679038805341 no 1101 0.333862369153213 1555 25236842
SGTC_67 0335-0847 266 µM 0.428977658924636 0.323786577930945 no 1102 0.3339697416275 1808 4552207 YOR254C SEC63
SGTC_1568 digitonin 820 nM 0.42821143814387 0.324065868975527 no 1103 0.334248594737874 1758 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3137 9097352 49.47 µM 0.426101465757641 0.324835475308601 no 1104 0.335016956093179 1673 44120435
SGTC_2899 9053889 58.44 µM 0.423753854667722 0.325692639093683 no 1105 0.335872667393289 1647 6470052
SGTC_232 clozapine 119 µM 0.423213957312901 0.325889897964417 no 1106 0.336069582200665 1609 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1749 st037932 54.2 µM 0.422913587426339 0.325999663311379 no 1107 0.336179154506255 1573 594497
SGTC_2667 digitoxin 100 µM 0.422779392596966 0.32604870752891 no 1108 0.336228112104603 1637 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2493 resveratrol 26.09 µM 0.421640085061044 0.326465211691307 no 1109 0.336643871544189 1558 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1470 k295-0292 231 µM 0.419016765514916 0.327425058198306 no 1110 0.337601939811129 1669 5045612
SGTC_3316 9136639 10.545 µM 0.418199750540006 0.32772422936152 no 1111 0.337900539078288 1672 4903665
SGTC_2839 9003951 25.97 µM 0.417547874038479 0.327963010155617 no 1112 0.338138857412777 1631 2990634
SGTC_1171 0368-0077 21.4 µM 0.416163164969101 0.328470459059462 no 1113 0.338645305830087 1573 3239779
SGTC_564 3555-0129 330 µM 0.415008392318259 0.328893886199725 no 1114 0.339067879760876 1610 563260
SGTC_552 k242-0005 476 µM 0.414191815552326 0.329193437749298 no 1115 0.339366817627235 1619 4088318
SGTC_3178 9107506 49.47 µM 0.411250864667549 0.330273198694942 no 1116 0.340444297296906 1631 8897194
SGTC_2461 5755302 26.15 µM 0.408934045100749 0.331124808720399 no 1117 0.341294031856387 1726 2788904
SGTC_3060 1327-0027 12.5 µM 0.408525672045108 0.331275008101744 no 1118 0.341443893504275 1705 16000455 YPR107C YTH1
SGTC_712 r015-0009 80.6 µM 0.407420177760178 0.331681744440815 no 1119 0.34184970481564 1679 6813872 YLR060W FRS1
SGTC_901 1112-0062 60.1 µM 0.404744124802447 0.332667145972537 no 1120 0.342832802089884 1621 1908457
SGTC_2205 7238770 200 µM 0.404522468139395 0.332748818472717 no 1121 0.342914279600162 1668 279867
SGTC_3091 9116372 49.47 µM 0.40229012516801 0.333571798445504 no 1122 0.343735260582833 1632 17169793
SGTC_450 aminopyrene 156 nM 0.4022717257926 0.333578584931328 no 1123 0.34374203032644 1692 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_100 0086-0128 49.5915 µM 0.402238790303708 0.333590733100795 no 1124 0.343754148515919 1528 93297
SGTC_562 3772-2733 112 µM 0.400998033439472 0.334048510048832 no 1125 0.344210785890754 1692 2876874 YIL048W NEO1
SGTC_1973 st070275 50.2 µM 0.400575188587203 0.334204575026493 no 1126 0.344366457985614 1635 17118334
SGTC_2491 paeonol 100 µM 0.399322302658845 0.334667162537631 no 1127 0.344827867895892 1603 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3236 9132701 49.47 µM 0.398041274108773 0.335140400395266 no 1128 0.345299880842316 1582 24282524
SGTC_2912 7964298 10.93 µM 0.396092579252333 0.335860789563034 no 1129 0.346018366241789 1615 2975850
SGTC_1799 st045822 46.1415 µM 0.395476527000059 0.336088656062783 no 1130 0.346245620741204 1740 3674992
SGTC_492 tmb-8 126 µM 0.394784084124336 0.336344849977722 no 1131 0.346501120947095 1700 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1455 4262-0120 131 µM 0.394323762704612 0.336515204358471 no 1132 0.346671010756022 1717 1529587
SGTC_338 4055-0136 114 µM 0.393477897877027 0.33682832697406 no 1133 0.346983272599616 1597 2900563
SGTC_155 k072-0202 43.6 µM 0.391418763618136 0.337591050766304 no 1134 0.347743862549466 1667 5857737
SGTC_1293 1000-1278 195 µM 0.39008211180927 0.338086517453467 no 1135 0.348237914941069 1698 678847
SGTC_2096 5468907 200 µM 0.3899264463196 0.338144237397796 no 1136 0.348295468685964 1752 759785
SGTC_3264 9137442 49.47 µM 0.389902339869752 0.33815317628278 no 1137 0.34830438180538 1718 17015726
SGTC_607 4491-0986 66.8 µM 0.3876854107559 0.338975622665262 no 1138 0.349124426782932 1755 698981 YDR232W HEM1
SGTC_1781 st038725 66.3 µM 0.387636361176847 0.338993827998757 no 1139 0.349142578271814 1637 4270275 YIL048W NEO1
SGTC_767 0929-0023 86 µM 0.387058563850439 0.339208312628271 no 1140 0.349356426294303 1636 1204563
SGTC_2056 5235370 200 µM 0.385545318516297 0.339770292521939 no 1141 0.349916718611298 1615 5511916
SGTC_859 0439-0102 54.6 µM 0.384933909499693 0.339997455046962 no 1142 0.350143190954013 1760 610143
SGTC_1129 3453-1384 223 µM 0.382004861767345 0.341086516284078 no 1143 0.351228879229552 1702 1084452
SGTC_3281 9140613 49.47 µM 0.381511919297934 0.341269929772599 no 1144 0.351411714245883 1559 16013766
SGTC_3064 1327-0027 10 µM 0.381281402284099 0.341355713160487 no 1145 0.351497226050399 1620 16000455 YPR107C YTH1
SGTC_2741 miltefosine 3.04 µM 0.380190563122654 0.341761763420473 no 1146 0.351901981894825 1663 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1247 0448-0043 5.84 µM 0.379463370505512 0.342032552901877 no 1147 0.352171899993825 1651 3089013 YGL099W LSG1
SGTC_430 0958-0115 16.4 µM 0.379360881005959 0.342070724125972 no 1148 0.352209947861238 1649 6833180
SGTC_946 3434-1334 87.4 µM 0.379302669446756 0.342092405177632 no 1149 0.352231558789301 1714 4047976
SGTC_692 k241-0027 77.8 µM 0.378697435140036 0.342317857156509 no 1150 0.352456279107955 1730 3600480
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.377425716634508 0.342791759973144 no 1151 0.352928629256258 1633 91467 include heat shock
SGTC_2532 xanthone 78.9 µM 0.377376410892389 0.342810138626682 no 1152 0.3529469472938 1730 7020 An insecticide.
SGTC_1273 0849-0096 14.1 µM 0.376062729233307 0.343299948694228 no 1153 0.353435130856877 1635 5286025
SGTC_2089 5281248 129.67 µM 0.374959630979944 0.34371144556583 no 1154 0.35384524486664 1627 2737878
SGTC_2148 5546263 113.568 µM 0.374213514823935 0.34398987983187 no 1155 0.354122734948012 1680 792097
SGTC_2215 7188065 200 µM 0.3735937733211 0.344221218177092 no 1156 0.354353283607837 1738 940217
SGTC_2894 9048625 32.47 µM 0.372152931974396 0.344759283538284 no 1157 0.354889494004029 1785 4092861
SGTC_1947 st076332 61.6 µM 0.369081716142532 0.345907240604673 no 1158 0.356033408383404 1758 24208416
SGTC_2906 7926292 26.41 µM 0.36595520155789 0.34707732383502 no 1159 0.357199252092334 1651 2966319
SGTC_1052 3253-3998 198 µM 0.365602852073171 0.347209280665574 no 1160 0.357330723296965 1646 5450317
SGTC_3042 9091578 49.47 µM 0.3631324199669 0.348134990640552 no 1161 0.358252983791149 1698 25236497
SGTC_3124 9127567 49.47 µM 0.358790248981083 0.349764262900177 no 1162 0.359876003920879 1799 17592030
SGTC_3230 9131665 49.47 µM 0.358499942044646 0.349873291197878 no 1163 0.359984605622518 1700 15943720
SGTC_2483 5729050 27.16 µM 0.356543319387077 0.350608447116246 no 1164 0.360716858270174 1825 2865180
SGTC_431 k089-0097 107 µM 0.356460293179077 0.350639654703296 no 1165 0.360747941580031 1673 5499420
SGTC_1384 3089-0840 101 µM 0.356440858431624 0.350646959910601 no 1166 0.360755217683856 1791 1069836
SGTC_2396 5342950 42.78 µM 0.355792834731704 0.350890573147414 no 1167 0.36099785774538 1668 1886677
SGTC_442 cape 100 µM 0.355637597970168 0.350948940813756 no 1168 0.361055991487439 1805 5281787
SGTC_2880 9042983 58.44 µM 0.355185375713916 0.351118992474477 no 1169 0.36122535994657 1683 6464714
SGTC_3188 9110789 49.47 µM 0.352910888059982 0.351974732273325 no 1170 0.362077623946048 1769 849217
SGTC_577 r071-0003 38.6 µM 0.349130223503948 0.353398805552363 no 1171 0.363495773700245 1659 4568517 YMR134W ERG29
SGTC_1854 st056233 32.9 µM 0.349052778620066 0.35342799847271 no 1172 0.36352484337529 1826 5393174
SGTC_770 0389-1121 67.2 µM 0.34837691817388 0.353682801272517 no 1173 0.363778567370077 1821 6753108
SGTC_2521 angolensin 13.4 µM 0.348355234532652 0.353690977200842 no 1174 0.363786708590689 1740 821428 A flavenoid.
SGTC_835 0312-0010 67.2 µM 0.348227159485712 0.353739269931712 no 1175 0.363834796197226 1696 1626196
SGTC_2121 5257820 149.641 µM 0.346954652469797 0.35421921667389 no 1176 0.364312693542419 1833 791256
SGTC_104 0074-0074 590.992 µM 0.346741374006762 0.35429968080637 no 1177 0.364392812166952 1787 3943124
SGTC_1138 3761-0006 1.03 µM 0.345830570236771 0.3546433753278 no 1178 0.364735024678376 1739 12061087
SGTC_1852 st056254 31.4 µM 0.344715525697201 0.355064301855312 no 1179 0.36515412248075 1757 442583
SGTC_2746 daunorubicin 9.88 µM 0.344463314469362 0.355159535519199 no 1180 0.365248940310809 1821 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1647 st011722 22.4 µM 0.343658788927477 0.355463380667577 no 1181 0.365551453583771 1731 2854783
SGTC_2271 7849410 118.62 µM 0.343201652526057 0.355636068316296 no 1182 0.36572338078157 1865 972430
SGTC_1972 st070201 17.4 µM 0.341995844892948 0.356091715783901 no 1183 0.366177009616008 1826 2829099
SGTC_1959 st077091 55.8 µM 0.341967563215619 0.356102405260994 no 1184 0.366187651524896 1696 821356 YKL052C ASK1
SGTC_2869 9037858 32.47 µM 0.341823326472399 0.356156923424654 no 1185 0.366241926932091 1659 27187042
SGTC_2007 4011539 71.82 µM 0.341595797585757 0.356242930076213 no 1186 0.366327550104915 1657 45595301
SGTC_2057 5236571 38.335 µM 0.34096579601832 0.356481110846348 no 1187 0.366564665629631 1831 54684039 YBR257W POP4
SGTC_1175 0741-0056 27.6 µM 0.338907092270837 0.35725982212377 no 1188 0.367339860724127 1810 765927
SGTC_2413 inermin 26.06 µM 0.338759956399524 0.357315499551857 no 1189 0.3673952847867 1848 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3165 9101544 49.47 µM 0.338626655165756 0.357365944461737 no 1190 0.367445499916472 1779 5002184
SGTC_1738 st035555 74 µM 0.338248601774801 0.357509023980105 no 1191 0.367587926530659 1730 5331140
SGTC_2399 5884133 200 µM 0.336975570414898 0.357990967433359 no 1192 0.368067658082055 1656 722445
SGTC_160 3453-0671 289.699 µM 0.335800062567268 0.358436191584631 no 1193 0.368510821494174 1659 5322268
SGTC_303 1348-1668 34.2 µM 0.331706280361598 0.359988212647321 no 1194 0.3700555289508 1766 5380509
SGTC_2207 7258803 200 µM 0.330694328561635 0.360372217674992 no 1195 0.370437693330037 1796 3666799
SGTC_766 1391-0721 126 µM 0.329631780006982 0.360775574271283 no 1196 0.370839103271057 1827 1020919 YIL115C NUP159
SGTC_1518 st038567 90.8 µM 0.328262202783548 0.361295711246315 no 1197 0.371356709983078 1727 77966
SGTC_1042 0350-0096 82 µM 0.327829404940248 0.361460132257539 no 1198 0.37152032646748 1679 3122515
SGTC_1126 isoteolin 1.0172 µM 0.327149808498533 0.361718364316776 no 1199 0.371777290437937 1651 133323
SGTC_919 tnp00227 403.569 nM 0.326257457510832 0.362057534171075 no 1200 0.372114786331968 1739 1269246 A methoxyflavone. YNL221C POP1
SGTC_3153 9100258 49.47 µM 0.326244607319251 0.362062419137193 no 1201 0.372119647118774 1674 25236848
SGTC_90 0870-0863 4.608 µM 0.32537891046706 0.362391563198138 no 1202 0.372447157443297 1698 1738164
SGTC_1621 st003705 32.4 µM 0.32503115017202 0.362523812780013 no 1203 0.372578748063526 1865 24207032
SGTC_367 0335-0881 7.1 µM 0.321811675443726 0.363748922234293 no 1204 0.37379768436373 1825 23828853
SGTC_2149 5554786 194.827 µM 0.321708013700004 0.363788391962017 no 1205 0.373836953147682 1760 745063 YPR165W RHO1
SGTC_146 3448-8650 53.125 µM 0.321188035239358 0.363986398165432 no 1206 0.374033949345741 1777 2891488 YIL048W NEO1
SGTC_53 0973-0023 39.979 µM 0.321181727468542 0.363988800368289 no 1207 0.374036339275412 1929 674768
SGTC_1841 st054148 70 µM 0.32098897155254 0.364062210623586 no 1208 0.374109374238227 1705 675442
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.320793494307305 0.364136662380071 no 1209 0.37418344492424 1817 5282309
SGTC_2896 9052656 71.43 µM 0.319249301870755 0.364724981670043 no 1210 0.37476873693588 1765 6469436
SGTC_371 0195-0006 7.36 µM 0.318314450309463 0.365081304169511 no 1211 0.375123212087917 1666 3928593
SGTC_1664 st014217 9.02 µM 0.317196969041574 0.365507389612491 no 1212 0.375547074811779 1810 3982782
SGTC_246 cycloheximide 667 µM 0.317137391115224 0.365530110800084 no 1213 0.375569677053641 1720 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1991 st073000 8.92 µM 0.316437488556573 0.365797067408697 no 1214 0.375835232971216 1830 4301969 YIL048W NEO1
SGTC_907 3448-6986 75.5 µM 0.315271065715904 0.366242108406903 no 1215 0.376277925913344 1848 590582
SGTC_297 0986-0032 24 µM 0.314889766565185 0.366387629663363 no 1216 0.376422675877171 1749 2847425
SGTC_2888 9058547 12.99 µM 0.313699254361518 0.366842107324677 no 1217 0.376874733569991 1694 16476514
SGTC_852 0418-0143 439 µM 0.313091099269922 0.367074342433169 no 1218 0.377105725579435 1863 5369229
SGTC_2140 5586273 200 µM 0.310126097214686 0.368207277833137 no 1219 0.378232533630909 1760 854421
SGTC_228 caffeine 993.056 µM 0.308585743425979 0.368796304634876 no 1220 0.378818333515056 1856 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_29 0299-0004 12.984 µM 0.307888534329469 0.369063016814012 no 1221 0.379083575283109 1818 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2581 avocatin a 64 µM 0.306437237689281 0.369618401706007 no 1222 0.379635879790765 1757 6710728 A skin care supplement.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.305992006657113 0.369788838146499 no 1223 0.379805365918762 1851 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_950 1165-0508 94.1 µM 0.305475875467577 0.369986447502186 no 1224 0.380001870513088 1710 6148369
SGTC_2747 doxorubicin 7.63 µM 0.304461495308032 0.370374919706442 no 1225 0.380388161718445 1876 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_355 1311-2252 105 µM 0.304365412083796 0.370411723090587 no 1226 0.380424757845846 1729 5338538
SGTC_2278 7948257 134.34 µM 0.303177914868957 0.370866675720515 no 1227 0.380877139409999 1936 1247028
SGTC_2831 7999036 19.48 µM 0.300062999396961 0.372060915377688 no 1228 0.382064550835734 1927 2988270
SGTC_2592 piperlongumine 83.33 µM 0.299802348153588 0.372160903485997 no 1229 0.382163962051435 1706 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1236 0330-0013 258 µM 0.298482182749109 0.372667462807899 no 1230 0.382667586408723 1779 4617066
SGTC_1948 st076329 66.6 µM 0.297933260665991 0.372878154037885 no 1231 0.382877050859523 1825 24208413
SGTC_633 0437-0093 97.7 µM 0.296904033904235 0.373273301734809 no 1232 0.383269888179951 1763 2831118
SGTC_2670 beta-carotene 100 µM 0.294097852048383 0.374351346214501 no 1233 0.384341566081906 1851 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_459 nigericin 15.3 µM 0.293553393954773 0.374560623575591 no 1234 0.38454959678576 1810 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2693 st077581 40.7 µM 0.293104044677844 0.37473337110095 no 1235 0.384721312635667 1858 25238761
SGTC_1380 2291-0730 164 µM 0.29203571010131 0.375144181788804 no 1236 0.38512966036986 1747 2999191
SGTC_605 1315-0399 119 µM 0.291403987702395 0.37538716704856 no 1237 0.385371182540287 1841 24020461
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.291251290932575 0.375445907650954 no 1238 0.385429568744192 1801 4620898
SGTC_181 1447-1644 8.07 µM 0.289875753259244 0.375975190400117 no 1239 0.385955645845929 1917 534600
SGTC_553 k007-0256 45.7 µM 0.289116675647845 0.37626737014396 no 1240 0.386246046473116 1813 6287000
SGTC_2596 sinensetin 100 µM 0.289024020173752 0.376303039410939 no 1241 0.386281498083115 1750 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_532 1548-0774 215 µM 0.288698772336388 0.376428257341003 no 1242 0.386405951125835 1915 5932993
SGTC_2710 st078562 53.7235 µM 0.28867206047566 0.3764385417812 no 1243 0.38641617268896 1780 17250908
SGTC_1073 triclabendazole 3.09 µM 0.288002681781304 0.376696290568808 no 1244 0.386672342920434 1804 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2903 5923464 63.88 µM 0.287934691008069 0.376722473952709 no 1245 0.386698365653188 1921 2876576
SGTC_2647 atorvastatin 60.16 µM 0.287222963626161 0.376996595619677 no 1246 0.386970802165328 1869 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1682 st012968 530 nM 0.287008081981789 0.377079369437692 no 1247 0.387053065967947 1725 24207270
SGTC_1221 2958-7315 257 µM 0.286574755002838 0.377246307008747 no 1248 0.387218973299939 1831 4562705
SGTC_1866 st057638 64 µM 0.28567541007169 0.377592849412242 no 1249 0.387563370037075 1789 688802
SGTC_2147 5545932 89.7195 µM 0.282375034973197 0.37886541752203 no 1250 0.38882797781138 1819 797404
SGTC_3170 9103054 49.47 µM 0.280351403629893 0.379646346026493 no 1251 0.389603958434968 1792 16432970
SGTC_321 4534-3890 65.3 µM 0.280335536020145 0.379652471353852 no 1252 0.38961004476419 1921 699746
SGTC_2475 5812728 15.03 µM 0.280215264890965 0.379698900250827 no 1253 0.389656177966765 1779 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2711 st079103 59.1 µM 0.27893668478195 0.380192584362407 no 1254 0.390146707502382 1921 54693780
SGTC_1417 3966-0327 90.4 µM 0.277615324581456 0.380702991845419 no 1255 0.390653833542348 1836 651118
SGTC_1996 st072960 66.8 µM 0.277578541935742 0.380717203011492 no 1256 0.390667953053184 1949 1719405
SGTC_2046 4110841 106 µM 0.276292408209477 0.381214208521373 no 1257 0.391161743218352 1944 44119630 YMR134W ERG29
SGTC_1669 st015249 58.4 µM 0.276165209077372 0.381263373225392 no 1258 0.391210588809259 1963 722793
SGTC_3120 9124077 49.47 µM 0.275782066199792 0.381411476270113 no 1259 0.39135772942584 1935 18774327 YGL155W CDC43
SGTC_526 4469-0568 170 µM 0.275345193085133 0.381580369810937 no 1260 0.391525523352578 1775 2901964
SGTC_1573 oleylamine 1.06 µM 0.275263877538333 0.381611808592629 no 1261 0.391556757201209 1762 5356789 An amine of the fatty acid oleic acid.
SGTC_2418 pentamidine 31.67 µM 0.275071268772348 0.381686279447631 no 1262 0.391630742313002 1917 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3194 9111903 49.47 µM 0.274968748577299 0.381725919962176 no 1263 0.391670124092807 1866 17087251
SGTC_1606 st000094 49.2 µM 0.271613421337154 0.383023974947005 no 1264 0.392959639285211 1977 1242210
SGTC_1652 st011932 78 µM 0.270273697234245 0.383542633935111 no 1265 0.393474849586709 1916 1551076
SGTC_2607 solasodine 47.35 µM 0.26985374631971 0.383705256184026 no 1266 0.393636386242438 1791 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1362 1611-0397 101 µM 0.2672797813935 0.384702447724447 no 1267 0.394626876390055 1808 27816
SGTC_2476 5806916 10.51 µM 0.266880773622456 0.384857097648801 no 1268 0.394780480167986 1869 2870194
SGTC_1970 st070122 35.8 µM 0.266680289648608 0.384934809396562 no 1269 0.394857665531852 1913 102928
SGTC_1262 0737-0114 49.6 µM 0.266406752837479 0.385040845394858 no 1270 0.394962982541914 1972 765919
SGTC_350 k064-0020 19.8 µM 0.266119088742448 0.385152367081192 no 1271 0.395073747111582 1969 2790705
SGTC_62 0180-0423 3.232 µM 0.265594234447508 0.385355867193758 no 1272 0.395275863207484 1895 30102 YGL099W LSG1
SGTC_1170 0310-0127 64.8 µM 0.265515980436322 0.38538621108226 no 1273 0.395306000452967 1868 774975
SGTC_2913 7966556 36.57 µM 0.26534166173459 0.385453807676107 no 1274 0.395373136457419 1924 2976516
SGTC_1449 4112-4002 201 µM 0.265138786507603 0.385532482183998 no 1275 0.395451274451748 1783 2059539
SGTC_790 1575-0012 79.1 µM 0.264575176996061 0.385751073258728 no 1276 0.3956683723727 1949 378741 YLR208W SEC13
SGTC_2066 5222451 176 µM 0.264572586050603 0.385752078218357 no 1277 0.395669370459181 1836 2281147
SGTC_3292 9120825 59.784 µM 0.26384451100751 0.386034509748398 no 1278 0.395949867308282 1989 24824900
SGTC_167 3672-0051 66.205 µM 0.263679448336253 0.386098548508262 no 1279 0.396013466547123 1800 3237971
SGTC_2600 tangeritin 87.95 µM 0.262453879308406 0.386574124990696 no 1280 0.396485769156346 1772 68077 A bioactive flavone.
SGTC_1288 0973-0013 65.5 µM 0.261146458096936 0.387081651693524 no 1281 0.396989782967861 1859 4315430
SGTC_1239 0337-0584 35.4 µM 0.261090419801909 0.387103409472531 no 1282 0.397011389708744 1980 914301 YML130C ERO1
SGTC_1200 1643-0193 18.4 µM 0.257764127194273 0.388395529832647 no 1283 0.398294475735239 1962 5403974
SGTC_1985 st071382 65.5 µM 0.256923896853029 0.388722118987216 no 1284 0.398618761312566 1838 6123237
SGTC_3053 9095903 49.47 µM 0.25684932136072 0.388751109541565 no 1285 0.398647546992343 1940 17174018
SGTC_2845 9003024 42.97 µM 0.255824337396142 0.389149625583842 no 1286 0.399043240281167 1931 2990173
SGTC_44 0929-0055 61.211 µM 0.255752175208036 0.389177686802562 no 1287 0.399071102283829 1819 1379590
SGTC_3238 9133470 49.47 µM 0.254288147851887 0.38974711777837 no 1288 0.39963647778947 1962 3534688
SGTC_611 3453-1652 23.7 µM 0.250502643207072 0.391220578125833 no 1289 0.401099330433918 1965 1560575
SGTC_2020 4017018 200 µM 0.248908107342746 0.391841700227376 no 1290 0.401715931940586 1844 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_774 k060-0086 136 µM 0.248554646868652 0.391979421646071 no 1291 0.401852647078934 2019 5911235
SGTC_1445 4239-0156 97.7 µM 0.248333622020428 0.392065548071628 no 1292 0.401938143485921 1977 4008346
SGTC_330 1488-0319 80.1 µM 0.248326202059086 0.392068439488758 no 1293 0.401941013742544 1871 6846614
SGTC_1490 4089-0339 670 nM 0.247814565459221 0.392267828859917 no 1294 0.402138942391325 1965 742542
SGTC_3321 9137793 26.8275 µM 0.246968563813221 0.392597585324007 no 1295 0.402466276520478 1961 4904192
SGTC_1038 k292-0204 154 µM 0.246051187555168 0.392955249494485 no 1296 0.40282130413601 1811 4454212
SGTC_2313 7726885 200 µM 0.245936407960212 0.393000005820411 no 1297 0.402865729861999 1867 726423
SGTC_739 1486-1183 203 µM 0.24460639654978 0.39351872387361 no 1298 0.403380605384514 2008 4346692
SGTC_1447 4239-0816 81.9 µM 0.244582534577585 0.393528032015767 no 1299 0.403389844390574 1789 1341554
SGTC_3083 9117465 49.47 µM 0.242559555146942 0.394317381996249 no 1300 0.404173307948499 1802 16420915
SGTC_2330 7979373 200 µM 0.242189684302675 0.394461749613406 no 1301 0.40431659394499 1753 1863007
SGTC_1530 rhein 70.4 µM 0.242050286814313 0.394516162863915 no 1302 0.404370599121487 1953 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2700 st077718 96.8 µM 0.24149611259535 0.394732502893805 no 1303 0.404585314520706 1819 904970
SGTC_205 1486-1330 71.903 µM 0.240984881073718 0.394932107628738 no 1304 0.404783417210403 1892 4118834
SGTC_3333 9141820 12.094 µM 0.239010574375743 0.395703212472491 no 1305 0.405548691590097 1847 1939433
SGTC_1757 st041620 31.8375 µM 0.238318572404755 0.395973584457416 no 1306 0.405817008790051 1852 5289815
SGTC_1899 st063254 59.6 µM 0.236000555818234 0.39687962032069 no 1307 0.4067161194377 1815 3093813
SGTC_1344 1488-0097 29.1 µM 0.235332386213002 0.397140889297653 no 1308 0.406975380145126 1905 747966
SGTC_1160 4092-0570 10.5 µM 0.235136626443385 0.397217444412567 no 1309 0.407051345856403 1819 4994975
SGTC_3251 9135047 49.47 µM 0.23475208906146 0.397367835680629 no 1310 0.407200577990676 1985 17682963
SGTC_485 niflumic acid 177 µM 0.23408899920024 0.397627203710723 no 1311 0.407457943032172 1946 4488 A COX2 inhibitor.
SGTC_1900 st060200 72.8 µM 0.232607712595432 0.398206773264247 no 1312 0.408033018896141 1851 688945
SGTC_2739 tacrine 100.86 µM 0.231847281938381 0.398504387405497 no 1313 0.40832831587725 1913 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1041 0206-0046 107 µM 0.231797071552525 0.398524040614135 no 1314 0.408347815840886 1877 50494
SGTC_2775 cyproheptadine 69.59 µM 0.231002556870121 0.398835061551608 no 1315 0.408656407826902 2023 2913 A selective serotonin reuptake inhibitor.
SGTC_1264 0783-0040 158 µM 0.230897600551117 0.398876152589879 no 1316 0.408697177428754 1822 2855798
SGTC_1575 cyproterone acetate 48 µM 0.230848545897636 0.398895358169919 no 1317 0.408716232729789 1840 9880 An androgen receptor antagonist and liver toxin.
SGTC_1389 3405-0187 19 µM 0.230032981523293 0.399214698813706 no 1318 0.409033070642013 1837 799890
SGTC_1478 0453-0656 35.7 µM 0.229306391727586 0.399499257589026 no 1319 0.40931539297396 1972 5258496
SGTC_2492 derrusnin 100 µM 0.227114859553966 0.40035786348123 no 1320 0.410167214844742 1899 1715307 Part of coumarin class of compounds.
SGTC_1843 st055809 45.5 µM 0.226495304124943 0.400600682536082 no 1321 0.41040810555589 1894 16413835
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.226304525756765 0.400675461024928 no 1322 0.410482289325132 1893 390807
SGTC_1473 k844-0725 134 µM 0.225218213068048 0.401101327136124 no 1323 0.410904760706551 1985 54682906
SGTC_291 SEC14.278 35.5 µM 0.22392653902783 0.401607853789832 no 1324 0.411407232439946 2002 1068044
SGTC_2158 5657123 3.6195 µM 0.22281420935843 0.402044183559203 no 1325 0.411840054264181 2017 2858827
SGTC_3159 9100096 49.47 µM 0.217750466533426 0.404032056180926 no 1326 0.413811770195282 1963 25236875
SGTC_3260 9137109 49.47 µM 0.216889457436255 0.404370310558823 no 1327 0.414147246901724 2036 17478346
SGTC_737 1950-0117 57.9 µM 0.216004085217523 0.404718210745385 no 1328 0.414492281596306 2036 5393513
SGTC_117 lucigenin 22.078 µM 0.214852847855296 0.405170693219759 no 1329 0.414941024134691 1806 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3044 9093193 49.47 µM 0.212137998861212 0.406238238829302 no 1330 0.415999687735248 1862 25236277
SGTC_3223 9129970 49.47 µM 0.2114242246745 0.406519028560502 no 1331 0.416278127701216 1930 17248386
SGTC_3339 9145883 14.936 µM 0.210743058100997 0.406787035702236 no 1332 0.41654388677855 2014 2030670
SGTC_800 3448-7362 155 µM 0.208510659288231 0.407665685460532 no 1333 0.417415130316815 2065 15991913
SGTC_2814 7977482 42.97 µM 0.208190384186055 0.407791780742597 no 1334 0.417540158204453 2016 6456762
SGTC_785 1270-0111 65.3 µM 0.207813895556682 0.407940020025933 no 1335 0.417687141193889 2055 6741994
SGTC_3215 9129942 49.47 µM 0.207111974662702 0.408216430747103 no 1336 0.417961205212446 2075 17682944
SGTC_2210 7115885 190.385 µM 0.20581820070694 0.40872602796823 no 1337 0.418466461730667 1958 2927039
SGTC_2960 9079389 5.97 µM 0.205631600728623 0.408799539522433 no 1338 0.418539345594668 2042 16457355
SGTC_407 eburnamonine 100 µM 0.205373644335455 0.408901167407578 no 1339 0.418640105080857 1906 3195
SGTC_1092 toremifene 6.32 µM 0.20446840057718 0.409257857533368 no 1340 0.418993741519161 2072 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_826 1683-5028 118 µM 0.204358795358254 0.40930105001139 no 1341 0.419036563605186 1939 722377
SGTC_2796 7949634 45.45 µM 0.203770710404643 0.409532817314539 no 1342 0.419266341153049 1918 2971588
SGTC_1077 5-fluorocytosine 377 nM 0.203263843330786 0.409732601608408 no 1343 0.419464407211385 1954 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1691 st019933 84.6 µM 0.20316183607394 0.409772811134251 no 1344 0.419504270574866 2079 6176082
SGTC_2718 lomofungin 53.02 µM 0.201870221787447 0.410282025460554 no 1345 0.420009091180125 2033 5351222 A RNA synthesis inhibitor.
SGTC_1055 3448-0672 86 µM 0.201598534614891 0.410389156448651 no 1346 0.420115295457829 1974 748378
SGTC_2787 5284540 71.43 µM 0.200111477131845 0.41097564740174 no 1347 0.420696698728985 1927 736958
SGTC_990 3985-0011 41.3 µM 0.199484461542667 0.411223000183438 no 1348 0.420941898492656 1967 5399565 YGL099W LSG1
SGTC_27 0485-0001 32.618 µM 0.198500688724465 0.411611162021808 no 1349 0.421326672974097 2061 2054479
SGTC_1557 sumaresinolic acid 42.3 µM 0.198275122319166 0.411700174726761 no 1350 0.421414907397959 1917 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_353 1988-1175 58.3 µM 0.196921147539424 0.41223457374638 no 1351 0.421944622176898 1891 2788357
SGTC_846 0335-0850 148 µM 0.196781662145319 0.412289636368828 no 1352 0.421999201009279 2048 6819598
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.195805508943283 0.412675026447127 no 1353 0.422381199014306 2048 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_86 0417-1630 471.922 µM 0.193583623736099 0.413552551004801 no 1354 0.423250960994945 2073 3634867
SGTC_3066 9117245 49.47 µM 0.193140546593023 0.413727594323211 no 1355 0.423424449423627 2007 17176980
SGTC_1846 st056244 14.8 µM 0.192603249964652 0.413939883257714 no 1356 0.423634849741828 1985 5393182
SGTC_837 0091-0265 12.5 µM 0.192566130623824 0.413954550248572 no 1357 0.423649386132183 1935 759367
SGTC_157 1348-1695 65.819 µM 0.192225700257318 0.414089070330675 no 1358 0.423782707694115 1984 5380510
SGTC_2682 pyrogallin 40.03 µM 0.192200387641946 0.414099072940781 no 1359 0.423792621134414 2036 822798 An ATP competetive kinase inhibitor.
SGTC_1467 k284-1082 293 µM 0.192038023372596 0.414163234624233 no 1360 0.423856210672314 2095 3334705
SGTC_1898 st060199 18.6 µM 0.190068513270159 0.414941710253905 no 1361 0.424627721531592 1902 688866
SGTC_1932 st074806 40.9 µM 0.188634701179485 0.415508654307251 no 1362 0.425189566717831 2011 17251235
SGTC_1810 st050138 53 µM 0.188030305550233 0.415747691339261 no 1363 0.42542644723926 2076 3444541
SGTC_1414 3917-0015 5.4 µM 0.187783282666474 0.415845397281807 no 1364 0.42552327056773 2048 6618702
SGTC_2875 9039966 71.43 µM 0.187532830087833 0.415944465096261 no 1365 0.425621442788095 2053 6463691
SGTC_768 0384-0033 77.3 µM 0.187108801155288 0.416112204110608 no 1366 0.425787663850825 1895 3965305 YMR134W ERG29
SGTC_3248 9135562 49.47 µM 0.183216009110956 0.417652840276766 no 1367 0.427314266763384 1956 17650701
SGTC_1317 1273-0028 910 nM 0.182752048590249 0.417836545065646 no 1368 0.427496287268216 1980 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1064 honokiol 6.76 µM 0.181824867886616 0.418203715188248 no 1369 0.427860084032393 1974 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2405 ticlatone 3.52 µM 0.181724162681998 0.418243599460245 no 1370 0.427899601309127 2028 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_33 0986-0033 35.816 µM 0.181348652355521 0.418392327643175 no 1371 0.42804696000152 2084 2848082
SGTC_745 0469-0705 296 µM 0.179912782442904 0.418961139337787 no 1372 0.428610520004834 2094 3486736
SGTC_765 1319-0117 244 µM 0.179780969166636 0.419013364926451 no 1373 0.428662262291139 2074 3487746 YGL099W LSG1
SGTC_1433 4060-0023 7.6 µM 0.178325300239715 0.419590208565693 no 1374 0.429233755263516 2052 3840627
SGTC_2193 5925765 200 µM 0.178067949122968 0.419692208117048 no 1375 0.429334806311132 2064 877370
SGTC_2974 9094440 9.66 µM 0.176014045163755 0.420506453284922 no 1376 0.430141454134432 2038 25236134
SGTC_2691 st077356 60.2 µM 0.175961228399912 0.420527396348946 no 1377 0.43016220118883 2045 2839272
SGTC_3114 9122766 49.47 µM 0.175617175418008 0.42066382678814 no 1378 0.430297354017578 1952 17176985
SGTC_697 0508-1955 564 µM 0.17500066363478 0.420908321607325 no 1379 0.430539556063503 2106 6243113
SGTC_947 3447-0010 211 µM 0.174910241193699 0.420944183697869 no 1380 0.430575081509911 2080 748350
SGTC_2673 kobusone 100 µM 0.174592672679919 0.42107013849929 no 1381 0.430699853253077 2046 6710676 An epoxy ketone and protein crosslinker.
SGTC_1676 st018489 23.4 µM 0.174206789168625 0.421223199433842 no 1382 0.430851475069008 1942 3696235
SGTC_401 neomycin 50 µM 0.172514659335037 0.421894524059899 no 1383 0.431516468825409 2011 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2098 5376439 882.5 nM 0.171982276527219 0.422105785208996 no 1384 0.431725731333233 2072 2844116
SGTC_738 1315-0003 72.4 µM 0.169299721398239 0.423170621603027 no 1385 0.432780447555466 2101 6251474
SGTC_2213 7173844 200 µM 0.168219122840489 0.423599722726966 no 1386 0.433205448731043 2043 892728
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.167927223399538 0.423715650328893 no 1387 0.433320266531744 2141 688664
SGTC_2097 5376186 200 µM 0.167374105119518 0.423935338860869 no 1388 0.43353784943632 2091 742755
SGTC_3020 9089140 49.47 µM 0.166215881656926 0.424395440682983 no 1389 0.433993530771991 1992 17217859
SGTC_141 0443-0274 32.331 µM 0.165033649184132 0.424865186306524 no 1390 0.43445874847978 2125 1627241
SGTC_3252 9135871 49.47 µM 0.164684413210952 0.425003971399757 no 1391 0.434596192958771 2082 17682838
SGTC_1423 4048-0112 5.59 µM 0.163329575996433 0.425542466561744 no 1392 0.435129474142591 2113 X1423
SGTC_3328 9140624 29.0385 µM 0.162879478611757 0.425721393577312 no 1393 0.435306664369702 2115 4904392
SGTC_479 n-linoleoylglycine 10 µM 0.162443863268368 0.425894578119539 no 1394 0.435478165809778 2002 6433346 An anti-infammatory.
SGTC_69 0096-0274 206.684 µM 0.162333529755977 0.42593844491174 no 1395 0.435521605959902 2070 6741392
SGTC_1761 st044296 37 µM 0.16215428893094 0.426009710073215 no 1396 0.435592177730546 2052 1826700
SGTC_2243 6634756 200 µM 0.162087907662334 0.426036103512084 no 1397 0.435618314281615 2114 885676
SGTC_1040 k898-0338 155 µM 0.162001031968644 0.426070646111003 no 1398 0.435652520605988 2167 20969351
SGTC_3187 9109394 49.47 µM 0.161494351897412 0.426272118201059 no 1399 0.435852029751942 1970 17098090
SGTC_1521 st012942 49.4 µM 0.160756476915765 0.42656555513449 no 1400 0.436142602844402 2140 24207259
SGTC_684 1140-0066 328 µM 0.160446449994113 0.426688858278761 no 1401 0.436264700866947 2006 6813534
SGTC_115 0527-0192 112.043 µM 0.160446051461641 0.426689016786729 no 1402 0.436264857825056 1992 4233931
SGTC_336 4111-0029 111 µM 0.160083426469412 0.426833248207396 no 1403 0.436407678281091 2002 3131175
SGTC_1776 st049249 45.9 µM 0.159609319044264 0.427021835699228 no 1404 0.436594418782026 1962 1822314
SGTC_3107 9121808 49.47 µM 0.159387384151027 0.427110121310154 no 1405 0.436681838920012 2140 662681
SGTC_2002 4023503 131 µM 0.159383519739504 0.42711165860385 no 1406 0.436683361138828 2177 4736863 YCR052W RSC6
SGTC_650 1328-0195 38 µM 0.158442089822257 0.427486199853527 no 1407 0.437054224871972 2142 2780821
SGTC_2502 avocadyne acetate 18.59 µM 0.157848230196908 0.427722496357006 no 1408 0.437288196410356 2141 3952079
SGTC_2340 7987427 183.45 µM 0.157826790055336 0.427731027866033 no 1409 0.437296643906358 2043 2239331
SGTC_2407 paclitaxel 400 µM 0.1576587203799 0.427797907697047 no 1410 0.437362864977361 2038 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1637 st007924 17.4 µM 0.156395503111015 0.428300644991643 no 1411 0.437860640779241 2072 683336
SGTC_3050 9093513 49.47 µM 0.156121445840921 0.42840973014908 no 1412 0.437968647149343 2083 25236664
SGTC_3139 9095020 49.47 µM 0.155339030776422 0.428721191006959 no 1413 0.438277023471117 2145 25236292
SGTC_3015 9080845 49.47 µM 0.154318663944435 0.429127441486564 no 1414 0.438679240943851 2121 5296973
SGTC_1969 st069479 40.1 µM 0.154177907639241 0.429183488329459 no 1415 0.438734730524234 2128 3895485
SGTC_2954 9074818 52.69 µM 0.154019868609261 0.429246418570151 no 1416 0.438797034812742 2051 16648742
SGTC_3040 9091894 49.47 µM 0.15184631709564 0.430112096156078 no 1417 0.439654074956785 2106 25236966
SGTC_3232 9132874 49.47 µM 0.15135458743933 0.430307987984968 no 1418 0.439848005330219 2002 3784940
SGTC_2560 caryophyllene 100 µM 0.15127838836798 0.430338345175467 no 1419 0.439878058327598 2163 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2760 etidronate 98.04 µM 0.149494406340194 0.431049188738155 no 1420 0.440581761432989 2044 3305 A chelator and antioxidant.
SGTC_805 3852-0218 479 µM 0.149207376001343 0.431163579463441 no 1421 0.440694999969859 1962 6615355
SGTC_1992 st073643 23.3 µM 0.148320107295724 0.431517220753502 no 1422 0.441045073767725 2129 3161292
SGTC_1094 duloxetine 25.4 µM 0.147767475637158 0.431737512537639 no 1423 0.441263139092602 2034 60834 A selective serotonin reuptake inhibitor.
SGTC_477 mead ethanolamide 10 µM 0.145740998287562 0.432545494516933 no 1424 0.442062927470654 2141 16061185
SGTC_2308 7584454 197.62 µM 0.143946254831623 0.433261316995038 no 1425 0.442771454966242 2123 893577
SGTC_1707 st032323 6.317 µM 0.143858217496392 0.433296435803085 no 1426 0.44280621500892 2078 3132057 YMR211W DML1
SGTC_1278 0874-0585 172 µM 0.143845289641324 0.433301592873828 no 1427 0.442811319389428 2073 766306
SGTC_47 0149-0135 24.25 µM 0.143340586147637 0.433502933796301 no 1428 0.443010601827667 2122 5239155
SGTC_1468 k284-1086 134 µM 0.143304429769126 0.433517358291777 no 1429 0.443024878746631 2026 15996457
SGTC_2678 equilin 100 µM 0.138192355690286 0.435557689763806 no 1430 0.445044198204467 2164 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2373 9071805 200 µM 0.134945694553909 0.436854392262358 no 1431 0.446327405459643 2212 10149009
SGTC_1151 3909-8316 15.3 µM 0.1348961700348 0.436874177433384 no 1432 0.446346983871438 2067 800431
SGTC_2496 diffractaic acid 79.83 µM 0.134889289973361 0.436876926047876 no 1433 0.446349703760312 2155 94870 An apoptosis inducer which activates caspases.
SGTC_2318 6029776 164 µM 0.134396460407522 0.43707382152348 no 1434 0.446544540214653 2099 818325
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.133306083068894 0.437509504862702 no 1435 0.446975658473186 2073 6708760
SGTC_289 k017-0060 526 µM 0.131458647320628 0.438247859609176 no 1436 0.447706248640811 2119 5512909
SGTC_2958 9077254 16.72 µM 0.131247450327233 0.43833228132291 no 1437 0.447789780321484 2071 16457351
SGTC_2952 9073731 13.78 µM 0.130527404497608 0.438620126107047 no 1438 0.448074586977036 2067 16457353
SGTC_949 1165-0505 146 µM 0.130390814629888 0.438674732801264 no 1439 0.448128616706785 2048 6244267
SGTC_789 1309-1135 70.6 µM 0.129393184902534 0.439073606369715 no 1440 0.448523270004834 2183 3092424
SGTC_1173 0443-0020 122 µM 0.129298205988992 0.439111584190173 no 1441 0.448560845466279 2059 5331295
SGTC_1772 st048439 82.2 µM 0.12717977188178 0.439958796296311 no 1442 0.449399057531685 2041 2927068 YDL195W SEC31
SGTC_2748 diazoxide 86.69 µM 0.127073716761479 0.440001217517963 no 1443 0.449441026891489 2148 3019 A potassium channel activatior.
SGTC_110 0850-0284 111.64 µM 0.126178527833448 0.440359313510092 no 1444 0.449795303906461 2191 3906265
SGTC_1079 idarubicin 2.36 µM 0.125386400561127 0.440676223182711 no 1445 0.450108826963077 2202 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1369 1866-0067 208 µM 0.124778330691307 0.440919522031733 no 1446 0.450349521451249 2164 3531355
SGTC_1435 4092-0789 56.7 µM 0.124296641999526 0.441112269508532 no 1447 0.450540202990405 2195 2248285
SGTC_210 3551-0445 56.827 µM 0.124019277011978 0.441223263294263 no 1448 0.450650006022963 2143 2865180 YOR207C RET1
SGTC_3171 9103192 49.47 µM 0.122993966635988 0.44163360411755 no 1449 0.45105593780966 2204 13018434
SGTC_2838 9002687 71.43 µM 0.121970563666172 0.442043244053299 no 1450 0.45146116548458 2026 6457060
SGTC_56 0957-0365 83.25 µM 0.121914348133462 0.442065747377957 no 1451 0.451483426113233 2191 6752360
SGTC_342 k048-0088 23.3 µM 0.119746180983555 0.442933816192509 no 1452 0.452342108199169 2131 6820570
SGTC_1118 chelidonine 707.474 nM 0.118784139283199 0.443319076718187 no 1453 0.452723187364613 2213 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_736 0958-0254 92.6 µM 0.118254796286985 0.443531081011022 no 1454 0.452932886671145 2143 6812352
SGTC_844 0330-0132 15.3 µM 0.117355408568656 0.443891326939988 no 1455 0.453289209317831 2191 2828079
SGTC_758 0868-0029 16 µM 0.116932068588909 0.444060910037547 no 1456 0.453456942702461 2225 762687
SGTC_3119 9125183 49.47 µM 0.116003489831408 0.444432919387569 no 1457 0.453824887992612 2193 22695334
SGTC_1320 1313-0481 95.3 µM 0.115767349298626 0.444527530369818 no 1458 0.453918463984621 2182 6813365 YLR208W SEC13
SGTC_334 1502-1024 68.5 µM 0.115605241716381 0.444592481479827 no 1459 0.453982704237686 2115 3296216
SGTC_879 0831-1030 162 µM 0.115535001610923 0.444620624813179 no 1460 0.454010539473426 2161 1549252
SGTC_2197 6588183 93.1375 µM 0.115070004761293 0.444806943660843 no 1461 0.454194817338516 2182 884136
SGTC_866 0495-0101 262 µM 0.114732696475618 0.444942106815003 no 1462 0.454328498504761 1989 635694
SGTC_659 k018-0002 107 µM 0.11337709570695 0.445485375412604 no 1463 0.45486579879522 2215 6797879 YHR007C ERG11
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.113063025056392 0.445611256556301 no 1464 0.454990294352912 2201 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.11260052265518 0.445796639893813 no 1465 0.455173635333713 2128 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1144 3486-0183 12.5 µM 0.112439884124137 0.445861030890144 no 1466 0.455237316430176 2119 6744069
SGTC_1349 flufenamic acid 69 µM 0.11200001807651 0.446037355873205 no 1467 0.455411696119339 2172 3371 A non-steroidal anti-inflammatory.
SGTC_1539 benzyladenosine 56 µM 0.111983226283573 0.446044087253681 no 1468 0.455418353197385 2172 92208 A nucleotide analog.
SGTC_2516 gossypol 71.55 µM 0.110982331119796 0.446445347364239 no 1469 0.455815178945591 2187 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2426 5582046 32.21 µM 0.110597807079103 0.446599518133016 no 1470 0.455967643258135 2189 2251934
SGTC_2898 9056270 58.44 µM 0.110565758891557 0.446612367873042 no 1471 0.455980350701739 2158 19154699
SGTC_25 0118-0223 35.662 µM 0.110384407161635 0.446685082013682 no 1472 0.45605225941896 2191 5333628
SGTC_2852 9023854 51.95 µM 0.107478045417773 0.447850649329719 no 1473 0.457204870820628 2174 19798528
SGTC_1165 k072-0275 30.3 µM 0.106829693569784 0.448110726158449 no 1474 0.457462045103336 2233 6153523 YGL055W OLE1
SGTC_1211 1056-0033 32.3 µM 0.106600329826912 0.448202737404837 no 1475 0.457553028456542 2224 6741922
SGTC_2677 mitomycin C 100 µM 0.106228034423601 0.448352092851728 no 1476 0.457700714265696 2199 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2023 5144124 124 µM 0.10530015561236 0.448724366047114 no 1477 0.45806881975115 2140 2830192
SGTC_2424 5537928 59.2 µM 0.105011161042641 0.448840322464133 no 1478 0.458183476228582 2132 5382802
SGTC_137 0438-0332 85.389 µM 0.104933224240919 0.448871594638673 no 1479 0.458214397679573 2205 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1429 4049-0205 9.46 µM 0.104802045969135 0.448924230692676 no 1480 0.458266443271747 2209 22774478
SGTC_3278 9139605 49.47 µM 0.102312027361608 0.449923534765449 no 1481 0.45925450447618 2178 7958859
SGTC_2008 4012253 172 µM 0.102059468331081 0.450024910597702 no 1482 0.459354736276453 2177 603940
SGTC_2393 9031399 185.94 µM 0.101806398986175 0.450126494538517 no 1483 0.459455173194006 2189 1526623 YDL150W RPC53
SGTC_2276 7947513 42.08 µM 0.100433431922005 0.45067767064444 no 1484 0.460000114551346 1975 2105100
SGTC_2724 maprotiline 69.64 µM 0.100203709058147 0.450769901952302 no 1485 0.460091300717573 2204 4011 A tricyclic antidepressant.
SGTC_3110 9122132 49.47 µM 0.100055563080697 0.450829382410595 no 1486 0.460150106877829 2190 918317
SGTC_2381 9035592 200 µM 0.0996654435772915 0.450986020270997 no 1487 0.460304967966292 2064 4749657
SGTC_1381 2324-0066 62.1 µM 0.098212826835214 0.451569330996714 no 1488 0.460881648682676 2148 10885928
SGTC_2605 digitonin 300 nM 0.0973472199145587 0.451916972697085 no 1489 0.461225328985382 2240 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_968 1309-0633 340 µM 0.0971696836025225 0.451988278708926 no 1490 0.461295821535005 2238 3761976
SGTC_378 3970-0959 8.33 µM 0.096545132331445 0.452239136926256 no 1491 0.461543815447024 2158 6615653
SGTC_1752 st044819 83.042 µM 0.0956978456375554 0.45257948985619 no 1492 0.461880275990238 2152 441209 YML126C ERG13
SGTC_1610 st001799 48.1 µM 0.0944693442315087 0.453073037600293 no 1493 0.46236816663686 2075 621897
SGTC_1329 1447-1697 50.6 µM 0.0924206778097647 0.453896245729477 no 1494 0.463181905610094 2170 2840515
SGTC_2712 st079126 47.7 µM 0.0923252753600482 0.453934585801581 no 1495 0.463219803647964 2221 3152970
SGTC_1015 4130-4525 82 µM 0.0920489828743743 0.454045623880633 no 1496 0.463329561024904 2044 1363237
SGTC_810 3825-7150 143 µM 0.0918676471337354 0.454118502127082 no 1497 0.46340159828837 2249 22330411 YGL099W LSG1
SGTC_1258 0671-0043 57.1 µM 0.089577087878299 0.455039202653456 no 1498 0.464311646209841 2152 4298767
SGTC_2825 7998094 58.44 µM 0.0892209325477675 0.455182382705369 no 1499 0.464453164975451 2185 2987815
SGTC_3338 9144300 39.5675 µM 0.0889213269752521 0.45530283337358 no 1500 0.464572217107465 2179 4901274
SGTC_1100 amiodarone 5.07 µM 0.0887871554189599 0.455356775804549 no 1501 0.464625532931851 2277 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_891 0929-0073 133 µM 0.0886565208398689 0.455409297017438 no 1502 0.464677443875934 2225 5603632
SGTC_3148 9097893 49.47 µM 0.0882237590127114 0.45558329308223 no 1503 0.464849416990476 2167 17174100
SGTC_2946 9065502 71.43 µM 0.0881461293140453 0.455614505753176 no 1504 0.46488026657378 2268 16489101
SGTC_1704 st028805 70.8 µM 0.0880614607211939 0.455648548873531 no 1505 0.464913913612689 2135 2876101
SGTC_3315 9136395 68.55 µM 0.0880404224130405 0.45565700790078 no 1506 0.464922274210694 2247 16876844
SGTC_1867 st057372 64 µM 0.0872060202756607 0.455992518272601 no 1507 0.465253877051042 2249 688837
SGTC_2124 5246320 200 µM 0.0870644822946813 0.456049433351818 no 1508 0.465310128583693 2185 579342
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0869836793655845 0.456081926130973 no 1509 0.465342242455724 2260 23665772 A membrane-active detergent.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0848982365493624 0.456920633271136 no 1510 0.466171146878548 2153 689007
SGTC_422 cantharidin 155 µM 0.0847518747029811 0.456979503189099 no 1511 0.466229327118438 2246 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_296 1222-0039 74.9 µM 0.0846156042285729 0.45703431498652 no 1512 0.46628349658983 2169 5984176
SGTC_1643 st009866 20.2 µM 0.0845935158067043 0.457043199644803 no 1513 0.466292277113724 2247 3156273 YOR207C RET1
SGTC_432 NS 1619 61.3 µM 0.0841332210705367 0.457228349549892 no 1514 0.466475255837793 2126 4552 A K+/calcium channel activator.
SGTC_1507 4075-3230 155 µM 0.0827339198806813 0.457791264196049 no 1515 0.467031556577249 2267 659771
SGTC_1481 3346-2004 36 µM 0.0825852373503894 0.457851081600755 no 1516 0.467090670030067 2274 2770522
SGTC_2891 9063876 19.48 µM 0.0819891692771984 0.458090899071739 no 1517 0.467327663061504 2288 6472478
SGTC_2543 pimpinellin 60.67 µM 0.0817133283608591 0.458201883966239 no 1518 0.467437339653184 2139 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3030 9087619 49.47 µM 0.0808210119252768 0.458560930738905 no 1519 0.467792148816018 2225 25236973
SGTC_2981 9013952 38.96 µM 0.0804797748294564 0.458698245330729 no 1520 0.467927840699161 2045 2996344
SGTC_1166 k206-0078 225 µM 0.079336532093385 0.459158324658484 no 1521 0.468382474728852 2253 5404595
SGTC_2384 9036245 200 µM 0.0790306931478182 0.459281413837028 no 1522 0.468504104903118 2220 6462766
SGTC_2817 7995342 71.43 µM 0.078995540641966 0.45929556170699 no 1523 0.468518085016351 2212 18879975
SGTC_3295 9122362 53.5725 µM 0.076980384900026 0.460106689407947 no 1524 0.469319574619427 2158 4730473
SGTC_343 4130-2827 29.8 µM 0.0765776422504053 0.46026881884066 no 1525 0.469479772807318 2159 1118244
SGTC_326 k292-0812 17.5 µM 0.0734273964250445 0.461537218193649 no 1526 0.470733008619473 2271 3579357
SGTC_3009 9080819 71.4286 µM 0.0731209506186741 0.46166062510537 no 1527 0.470854935050192 2198 17027216
SGTC_793 0488-0545 106 µM 0.0724039813915483 0.461949365787758 no 1528 0.47114020821037 2108 292548
SGTC_911 3456-4043 236 µM 0.0722493925798218 0.462011625038805 no 1529 0.471201719126391 2226 914281
SGTC_1931 st074438 57.1 µM 0.0722462571131064 0.46201288782941 no 1530 0.471202966736275 2279 2787313
SGTC_989 1501-0895 10.3 µM 0.0721399741432746 0.462055692890929 no 1531 0.47124525715731 2294 2830112
SGTC_1306 1185-0270 9.02 µM 0.071651993804899 0.462252230748278 no 1532 0.471439430650749 2261 1548076
SGTC_1021 4476-0760 85.3 µM 0.0714454613633461 0.462335416066043 no 1533 0.471521614545629 2229 746768
SGTC_2028 5153890 36.43 µM 0.0713653807749123 0.462367670663557 no 1534 0.471553480735928 2251 2830968 YPR165W RHO1
SGTC_2267 7931562 200 µM 0.0711253548020174 0.462464349021549 no 1535 0.471648994527466 2212 934880
SGTC_2698 st077697 67.5 µM 0.0689266674380767 0.46335004517114 no 1536 0.472523995723948 2192 3154499
SGTC_3200 9114385 49.47 µM 0.0647092258102626 0.465049459909288 no 1537 0.474202758542945 2206 17018030 YLR208W SEC13
SGTC_563 tetrahydrosecaminediol 614 µM 0.0607613335747168 0.466640838406944 no 1538 0.475774642366239 2295 334274 A psychoactive constituent of the cannabis plant.
SGTC_1815 st051655 58.2 µM 0.0605156893757196 0.466739874425698 no 1539 0.475872460217947 2301 5984156
SGTC_2175 5807670 165.306 µM 0.0595902359839575 0.467113006582908 no 1540 0.476240997552989 2293 241186
SGTC_601 0986-0029 62.9 µM 0.0591243584077814 0.467300854017631 no 1541 0.476426528686009 2272 24747981
SGTC_2553 4-methylesculetin 85.09 µM 0.0589473081444403 0.467372244722509 no 1542 0.476497038543078 2284 5319502
SGTC_2090 5301565 104.445 µM 0.0588903735123701 0.467395202288025 no 1543 0.476519712784833 2263 2056344
SGTC_2258 7960471 200 µM 0.0585469672998872 0.467533675149351 no 1544 0.476656476066483 2159 2974708
SGTC_808 0711-0032 135 µM 0.0582935586822424 0.467635860493065 no 1545 0.476757399109486 2298 4252555
SGTC_2110 5483698 200 µM 0.0580273243605063 0.46774322001413 no 1546 0.476863431749902 2234 2848765 YHR062C RPP1
SGTC_2477 5967686 25.23 µM 0.0578585659575581 0.46781127339209 no 1547 0.476930643689002 2286 776118
SGTC_2453 5731132 22.18 µM 0.0574197990272954 0.467988214589515 no 1548 0.477105395838708 2284 1362040
SGTC_1494 4358-1428 177 µM 0.0565451225582445 0.468340963522824 no 1549 0.47745377519939 2317 1564571
SGTC_3329 9141233 27.5565 µM 0.0551937908165253 0.468885991890934 no 1550 0.477992037803812 2286 4909101 YNL103W MET4
SGTC_2755 lomerizine 42.69 µM 0.0551131093959883 0.468918534728638 no 1551 0.478024176115693 2279 3949 A calcium channel blocker.
SGTC_2982 9019404 25.97 µM 0.0546430471005785 0.469108138400622 no 1552 0.47821142167096 2258 22333232
SGTC_1807 st050092 58.9 µM 0.053860403903313 0.469423839791584 no 1553 0.478523191978175 2269 5008496
SGTC_2709 st078560 56 µM 0.0535938616977349 0.469531361568641 no 1554 0.478629373570383 2307 17250903
SGTC_3280 9140961 49.47 µM 0.0523777563968595 0.47002196037107 no 1555 0.479113848803825 2273 4901226
SGTC_170 4197-0004 226 µM 0.052134428530105 0.4701201287071 no 1556 0.479210790128437 2264 218692
SGTC_475 α-linolenic acid 10 µM 0.0517046989258563 0.470293503500551 no 1557 0.479381996524319 2306 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3197 9113331 49.47 µM 0.0515649814809551 0.470349873843468 no 1558 0.479437661465144 2289 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1308 1187-1617 41.4 µM 0.0510717568922823 0.470548874776857 no 1559 0.479634170673997 2299 2882570
SGTC_93 0109-0045 59.227 µM 0.0489825170944446 0.471391899670541 no 1560 0.480466614275703 2315 88733
SGTC_2281 7943571 200 µM 0.0481174348635281 0.471741004987327 no 1561 0.480811325643799 2339 1244024
SGTC_529 4076-0302 30.3 µM 0.0470946544325975 0.472153777655498 no 1562 0.481218893878571 2186 5816522
SGTC_2400 5203494 178.7 µM 0.04603766355588 0.472580388361911 no 1563 0.481640115272299 2326 6777674
SGTC_2406 ethylparaben 405.7 µM 0.0445908427877926 0.473164388701758 no 1564 0.482216720898935 2210 8434 A possible steroid mimic.
SGTC_2720 fluspirilene 36.88 µM 0.0440972283465534 0.473363646407735 no 1565 0.482413451048206 2317 3396 An atypical antipsychotic.
SGTC_2327 6189656 200 µM 0.0439627111878798 0.473417948206212 no 1566 0.482467063637298 2319 5349088
SGTC_2671 danthron 100 µM 0.0437247925368112 0.473513992260195 no 1567 0.482561888262985 2287 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3111 9122088 49.47 µM 0.043511741976779 0.473599998759964 no 1568 0.482646802323891 2330 16876704
SGTC_2994 9053520 71.4286 µM 0.0426092678071382 0.473964332661687 no 1569 0.483006503779809 2312 4647384
SGTC_962 1254-0300 21.5 µM 0.0423882139981437 0.474053576660611 no 1570 0.483094611886424 2306 7340576
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0423292803952679 0.474077369596162 no 1571 0.483118101909243 2338 16725076
SGTC_3272 9137413 49.47 µM 0.0422347589559748 0.474115530403924 no 1572 0.483155776815693 2340 17614870
SGTC_2040 5100729 123 µM 0.041931507039663 0.474237962833589 no 1573 0.483276649746477 2304 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1307 1187-1599 12.2 µM 0.0419022449956867 0.474249776978987 no 1574 0.483288313361898 2277 1538471
SGTC_2990 9074105 71.4286 µM 0.0417685742444443 0.474303744983222 no 1575 0.483341593630173 2338 6502001
SGTC_2361 9034121 116 µM 0.0412602906481765 0.474508962844507 no 1576 0.483544194783449 2294 6496917
SGTC_3352 9151559 45.5865 µM 0.041098666367865 0.4745742195459 no 1577 0.483608618895594 2296 17159339
SGTC_1882 5615643 20 µM 0.0409992234036859 0.474614370534424 no 1578 0.483648257488576 2339 2253075
SGTC_761 k216-0224 480 µM 0.0408614596474314 0.474669994312307 no 1579 0.483703171258016 2351 1340404
SGTC_1835 st008666 49.2 µM 0.0404682912675579 0.474828743498584 no 1580 0.483859893113327 2282 690455
SGTC_981 1488-1094 54.9 µM 0.0399218133020837 0.475049400968535 no 1581 0.484077730231833 2328 3449522
SGTC_16 erodoxin 22.806 µM 0.0395503355473505 0.475199401035757 no 1582 0.484225811460571 2327 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1056 3448-1962 115 µM 0.0385561587606063 0.475600859764206 no 1583 0.484622128260929 2295 715507
SGTC_2928 9011484 9.79 µM 0.0377663913654235 0.475919793570063 no 1584 0.484936970525185 2299 2994751
SGTC_154 3389-1638 511.116 µM 0.0363047464252273 0.476510093966055 no 1585 0.485519682668151 2143 5238686
SGTC_1354 1498-1681 81 µM 0.0360669606260774 0.476606131125127 no 1586 0.485614483389775 2278 5754243
SGTC_2280 7785178 200 µM 0.0358903460597116 0.476677463267156 no 1587 0.485684896818983 2318 2954328
SGTC_1272 0839-0021 27 µM 0.0357052958939345 0.476752203230973 no 1588 0.485758673866801 2295 5027250
SGTC_478 N-arachidonylglycine 10 µM 0.0343851194123303 0.477285433257147 no 1589 0.486285024722177 2347 5283389
SGTC_1314 1222-0010 41.1 µM 0.0335931320947411 0.477605342960013 no 1590 0.486600799486684 2308 3526027
SGTC_2692 st077426 47.7 µM 0.0335815161140823 0.477610035144199 no 1591 0.486605430979347 2336 25238571
SGTC_3351 9150312 21.596 µM 0.0334172086943836 0.477676406168497 no 1592 0.48667094338641 2341 4904905
SGTC_1012 4112-3522 18 µM 0.0324503629627516 0.478066970346051 no 1593 0.487056449888898 2353 3112398
SGTC_638 3970-0837 4.09 µM 0.0314671839106012 0.478464154083748 no 1594 0.487448481311861 2332 4118451 YLR208W SEC13
SGTC_1508 1080-0625 72.9 µM 0.0304605208391545 0.478870847031512 no 1595 0.487849889283125 2341 767111
SGTC_2824 7998404 51.95 µM 0.0304223914494367 0.478886251780471 no 1596 0.487865093662362 2320 837851
SGTC_820 1582-0060 59.9 µM 0.0300520608643647 0.479035871592578 no 1597 0.488012766666233 2315 3848840
SGTC_3008 9078912 71.4286 µM 0.0294475377727196 0.479280115471128 no 1598 0.488253829783169 2344 16648731
SGTC_3158 9100007 49.47 µM 0.028488482574982 0.47966761595266 no 1599 0.488636276938041 2343 19297233
SGTC_1994 st072947 40.9 µM 0.0279533197734712 0.479883853639206 no 1600 0.488849691003456 2288 5286565 YDL195W SEC31
SGTC_1988 st071872 53.4 µM 0.027940616699329 0.479888986510897 no 1601 0.488854756818152 2369 16414116
SGTC_1702 st027038 51 µM 0.0260956753074626 0.480634498320447 no 1602 0.489590513247088 2301 5521182
SGTC_2430 5571206 200 µM 0.0260787703783005 0.480641329653697 no 1603 0.489597255043646 2364 1731771
SGTC_2762 leflunomide 42.06 µM 0.0246551364824622 0.481216644637512 no 1604 0.490165020045815 2356 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_286 k060-0067 22.9 µM 0.0234755470762066 0.481693366728671 no 1605 0.490635471857601 2354 5985051
SGTC_1383 3049-0032 20.7 µM 0.0230034587452814 0.481884165012043 no 1606 0.490823757000276 2345 712864
SGTC_1690 st023502 41.2 µM 0.0220616818170639 0.482264804059733 no 1607 0.491199376255578 2372 24207482
SGTC_1671 st016596 74.5 µM 0.0206712459510603 0.482826807552541 no 1608 0.491753953262251 2370 2829167
SGTC_2290 7904846 200 µM 0.0195624559271155 0.483274996470702 no 1609 0.492196206963871 2361 2962154
SGTC_1919 st067113 52.3 µM 0.019472273456125 0.483311450463062 no 1610 0.492232177712711 2338 1268243
SGTC_3099 9120367 49.47 µM 0.0168174868592553 0.48438464228411 no 1611 0.493291109686758 2369 24824940
SGTC_76 0433-0009 400.328 µM 0.0166810796309078 0.484439787737381 no 1612 0.493345520664734 2265 2841569
SGTC_2551 apiole 73.87 µM 0.0165436376716291 0.484495351803116 no 1613 0.493400344507946 2370 10659 A possible DNA adduct former.
SGTC_2808 7946468 45.46 µM 0.0162012393158049 0.484633775501957 no 1614 0.493536923381486 2368 2970879
SGTC_2431 5490079 200 µM 0.0151791972405786 0.485046974311579 no 1615 0.493944608974192 2371 5722345
SGTC_1114 scopoletin 1.73284 µM 0.0146666245986999 0.485254207083876 no 1616 0.494149073102916 2384 5280460 A coumarin with genotoxic properties.
SGTC_2191 5911152 200 µM 0.0145361994564367 0.485306938518485 no 1617 0.494201099660196 2374 2875902
SGTC_424 splitomicin 100 mM 0.0139850175357238 0.485529786517972 no 1618 0.494420967071979 2311 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1591 genipin 88.4 µM 0.0135044160299533 0.485724101886996 no 1619 0.494612681220901 2376 442424 A DNA cross-linking agent.
SGTC_481 bay k-8644 50 µM 0.012562423529108 0.486104975279207 no 1620 0.494988449926141 2376 2303 A calcium channel antagonist.
SGTC_2289 7946404 165.07 µM 0.0114163497924721 0.486568381368206 no 1621 0.495445634310869 2380 1246120 YPR165W RHO1
SGTC_2635 hydroquinidine 100 µM 0.00922120217569933 0.487456022508221 no 1622 0.496321324709367 2384 442912 An experimental heart treatment.
SGTC_3059 1327-0034 3 µM 0.00889125901712919 0.487589445494687 no 1623 0.496452947587196 2388 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1883 5-benzylidenerhodanine 20 µM 0.00868560888342808 0.48767260735593 no 1624 0.496534986952075 2391 1273210
SGTC_1674 st016616 23.6 µM 0.00800808737168572 0.487946590770003 no 1625 0.496805269508381 2384 625830
SGTC_2567 aureobasidin a 60 nM 0.00758052397103039 0.488119496378694 no 1626 0.496975837443973 2366 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2306 7482397 179.52 µM 0.00724342722635007 0.48825581906567 no 1627 0.497110315893377 2394 891448
SGTC_331 k048-0133 24.5 µM 0.00691393940330234 0.48838906601364 no 1628 0.497241759223068 2393 6813582
SGTC_583 1488-1091 88.9 µM 0.00633117780999299 0.488624741631226 no 1629 0.497474242360532 2396 4303273
SGTC_1693 xanthone 101.9 µM 0.00456205823531764 0.489340218309008 no 1630 0.498180008397339 2393 7020 An insecticide.
SGTC_60 0986-0278 202 µM 0.00448919360628832 0.489369687358251 no 1631 0.498209076880916 2380 3110598
SGTC_2085 5307070 144.047 µM 0.00388224244419358 0.489615162249416 no 1632 0.498451213236746 2396 2840351
SGTC_2091 4-phenylthiadiazole 200 µM 0.00278601717755351 0.490058528712245 no 1633 0.498888541391786 2400 270010
SGTC_92 0063-0024 660.874 µM 0.00164850699912258 0.49051860576775 no 1634 0.499342341156385 2399 3594437
SGTC_495 decylubiquinone 155 µM 0.000798260130101806 0.490862504656035 no 1635 0.499681540317165 2404 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_198 3454-2873 16.191 µM 0.000306640869175476 0.491061352746468 no 1636 0.499877667994304 2402 710957
SGTC_412 gemfibrozil 100 µM 0.00022921757019355 0.491092668800463 no 1637 0.49990855542064 2404 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2585 alliin 100 µM 0 0.491185382683287 no 1638 0.5 2405 87310 A garlic compound which reacts with lipids.
SGTC_570 0987-0065 62.6 µM -0.000232961413555982 0.491279611363153 no 1639 0.499907061843271 2406 3104428
SGTC_2586 curcumin 80 µM -0.000964299554452206 0.491575427556224 no 1640 0.499615300196377 2407 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3010 9080089 71.4286 µM -0.00103542414826557 0.491604196723468 no 1641 0.499586925602918 2407 17027233
SGTC_751 0833-0568 350 µM -0.00127021614164812 0.491699167981059 no 1642 0.499493257212115 2411 6954252
SGTC_780 0109-0199 192 µM -0.00130398184004316 0.491712825942347 no 1643 0.499479786658557 2407 610414
SGTC_1701 st028638 40.4 µM -0.00250591082723256 0.492199003038655 no 1644 0.499000287266399 2412 3490878
SGTC_3029 9088683 49.47 µM -0.00280258380058159 0.492319008282861 no 1645 0.498881932291219 2421 25236615
SGTC_3302 9125395 16.351 µM -0.00298625938727731 0.492393306042328 no 1646 0.498808656640852 2416 17599668
SGTC_2362 9071156 126 µM -0.00443109041306863 0.492977756934577 no 1647 0.498232256470759 2418 653133
SGTC_1877 wortmannin 25 µM -0.00451386584840784 0.493011241025853 no 1648 0.498199234180108 2410 312145 A covalent inhibitor of PI 3-kinase.
SGTC_24 0417-1663 219 µM -0.00475478543551413 0.493108697433515 no 1649 0.49810312220297 2419 4329390
SGTC_1400 3771-8998 51.5 µM -0.00550223026457254 0.49341105521702 no 1650 0.497804938786707 2415 670767
SGTC_1194 1488-0194 225 µM -0.00601604997591541 0.493618908736008 no 1651 0.497599957781006 2417 1391452
SGTC_1983 st071813 46.9 µM -0.00607458709440004 0.493642588643235 no 1652 0.497576605276195 2431 11838595
SGTC_3210 9128157 49.47 µM -0.00635444188995357 0.49375579807006 no 1653 0.497464961522113 2442 17590849
SGTC_2479 5617353 43.85 µM -0.00833702365329949 0.494557824087749 no 1654 0.496674047300961 2433 2731746
SGTC_1123 mangostin 811.285 nM -0.00961270350290107 0.495073894553312 no 1655 0.496165145203185 2445 5281650 An antioxidant.
SGTC_109 0132-0036 33.701 µM -0.00979305321468586 0.49514685489185 no 1656 0.496093199464769 2418 67274 A color developer.
SGTC_1454 4239-0054 42.6 µM -0.0109733208463921 0.495624335159493 no 1657 0.495622366212705 2439 1340767
SGTC_1506 4226-2149 212 µM -0.011399308228259 0.495796671011945 no 1658 0.495452432468992 2454 991114
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0119359598462808 0.496013777884026 no 1659 0.495238354023425 2428 6710655
SGTC_1795 st049545 62.3 µM -0.011943507223169 0.49601683124664 no 1660 0.495235343270288 2426 5291882
SGTC_618 k072-0232 33.2 µM -0.0125495531009926 0.496262013577603 no 1661 0.494993584079361 2434 5872756 YGL099W LSG1
SGTC_1525 8-methoxypsoralen 92.5 µM -0.0132407366911095 0.496541640997271 no 1662 0.494717864652154 2439 4114 Related to psoralen; DNA damaging agent.
SGTC_527 4476-4215 268 µM -0.0134113229279896 0.49661065417162 no 1663 0.494649816632247 2446 4418754
SGTC_1324 1418-0026 34.4 µM -0.0136274630169697 0.496698096973125 no 1664 0.494563597092135 2469 1372513
SGTC_1106 tegaserod maleate 11.7 µM -0.0136276522157403 0.496698173516471 no 1665 0.494563521619754 2442 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1677 st019204 53.9 µM -0.0143551322918761 0.496992487925952 no 1666 0.494273327471089 2473 3945625
SGTC_566 0958-0068 16.5 µM -0.0148971026957706 0.497211752322463 no 1667 0.494057135690363 2438 6815365
SGTC_648 0375-0473 33.3 µM -0.0167038829963292 0.497942725241417 no 1668 0.493336424705465 2436 1713139
SGTC_400 oxethazaine 37.5 µM -0.0171779331680528 0.498134513963517 no 1669 0.49314733318675 2453 4621 A local anesthetic.
SGTC_1837 st055472 66.5 µM -0.0173418708921602 0.498200839127212 no 1670 0.493081941238318 2511 676091
SGTC_799 1310-0557 151 µM -0.0173656561109296 0.498210462044825 no 1671 0.493072453737605 2492 5354492
SGTC_1206 3978-0017 132 µM -0.0182963793632454 0.498587010664372 no 1672 0.492701207916905 2510 3873677
SGTC_1192 1488-0095 21.4 µM -0.0196729259247309 0.499143931062184 no 1673 0.492152144290788 2473 915875
SGTC_1759 st043059 70 µM -0.0197968190246775 0.499194055577631 no 1674 0.492102727718955 2455 669426
SGTC_1600 coumarin 106 71.1 µM -0.020938971927151 0.499656146867825 no 1675 0.491647169164532 2553 100336 A hepatotoxic, DNA x-linker.
SGTC_1942 st076330 65.2 µM -0.0210143472402828 0.499686642173581 no 1676 0.491617105380297 2494 24208414
SGTC_2296 7971656 126.45 µM -0.0212295597834648 0.499773712764047 no 1677 0.491531267147652 2452 666570
SGTC_3310 9130229 44.1445 µM -0.0217750255994457 0.499994397108554 no 1678 0.49131370807372 2505 7761258
SGTC_2136 5328288 199.296 µM -0.0218027229478325 0.499994397108554 no 1679 0.491302661053019 2451 262395
SGTC_438 sphingosine 6.67 µM -0.0236197829550634 0.499259252073329 no 1680 0.49057794601826 2451 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2797 7859098 81.82 µM -0.023885766153488 0.499151640903746 no 1681 0.490471864004499 2461 972681
SGTC_1967 st070177 51.4 µM -0.0240189074047787 0.499097774795586 no 1682 0.490418763564562 2467 5729214
SGTC_1938 st074717 56.4 µM -0.0244143108145122 0.498937803117283 no 1683 0.490261066674622 2437 17250979
SGTC_536 3852-0578 10.6 µM -0.0263715441599394 0.4981459517986 no 1684 0.489480495362132 2446 2869208
SGTC_2669 eugenol 100 µM -0.0265056636659876 0.498091690382108 no 1685 0.489427008117636 2441 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_748 act1.228 77.9 µM -0.0269375779074631 0.497916948867003 no 1686 0.4892547607737 2458 4421505 YNR035C ARC35
SGTC_335 4077-0256 27.6 µM -0.0283161475411749 0.49735921749846 no 1687 0.488705000944209 2522 3121989
SGTC_1711 st032263 62.8 µM -0.0283857944648233 0.497331040395982 no 1688 0.488677227005949 2483 3958979
SGTC_834 0312-0008 75.7 µM -0.0286601947495076 0.497220026220205 no 1689 0.488567801652144 2456 6385573 YIL048W NEO1
SGTC_2640 pentamidine 10.38 µM -0.0294780850446354 0.496889133497487 no 1690 0.488241648473037 2468 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2878 9043973 25.97 µM -0.0307311311335515 0.496382194638661 no 1691 0.48774198191362 2558 6465167
SGTC_1364 1653-0028 37.6 µM -0.0311358448070001 0.496218462773512 no 1692 0.48758060174818 2496 5718652
SGTC_2263 7948595 193.29 µM -0.0314530849633889 0.496090119833226 no 1693 0.487454103195223 2465 2971371
SGTC_1120 ficusin 1.78878 µM -0.0328904229837874 0.495508634440064 no 1694 0.486880985008621 2547 6199 A DNA cross-linker.
SGTC_2259 7964009 200 µM -0.0343788100780364 0.494906506850747 no 1695 0.486287540295095 2591 313134
SGTC_845 0330-0138 4.51 µM -0.0345162068453713 0.494850923498148 no 1696 0.486232759427435 2458 9039800
SGTC_2663 amphotericin b 100 µM -0.0349991978277733 0.494655532088236 no 1697 0.486040190261711 2472 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_519 k048-0011 62.8 µM -0.035101215034464 0.494614261737189 no 1698 0.485999516276667 2556 6836379
SGTC_440 fluspirilene 35.1 µM -0.0353092598973096 0.494530098814788 no 1699 0.48591656980303 2677 3396 An atypical antipsychotic.
SGTC_1817 st052116 64.4 µM -0.0356249639927626 0.494402383658005 no 1700 0.485790701282696 2485 4361398
SGTC_932 2857-0803 154 µM -0.0361046404722739 0.49420833610014 no 1701 0.485599461090101 2640 674898
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0368861028708587 0.493892207503542 no 1702 0.485287910254957 2496 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2827 7993847 71.43 µM -0.0373117113414983 0.493720035742197 no 1703 0.485118233847859 2497 2985692
SGTC_1990 st072050 59.8 µM -0.0376995519474057 0.493563143265627 no 1704 0.484963616619221 2468 17233948
SGTC_1723 st034307 2.5525 µM -0.0386030955225443 0.493197638279655 no 1705 0.484603417131978 2503 867466
SGTC_1048 3161-0300 24.5 µM -0.0389422436067059 0.493060446225907 no 1706 0.484468218284298 2481 2165101
SGTC_1019 4262-0212 3.4 µM -0.0397113501254747 0.492749330616847 no 1707 0.484161626362139 2477 4677213
SGTC_734 2023-0417 80 µM -0.0409065301971542 0.492265870417221 no 1708 0.483685205731107 2520 3935732
SGTC_395 anisomycin 6.25 µM -0.0425238506301544 0.491611669180266 no 1709 0.48304054944532 2521 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2353 9059630 146.67 µM -0.0429848805278738 0.491425188032963 no 1710 0.48285679315234 2516 4779114
SGTC_427 1354-0053 47.3 µM -0.043696251498113 0.49113745057062 no 1711 0.482573263617924 2691 6813657
SGTC_1222 0366-0074 1.18 µM -0.0437509050974008 0.491115344307822 no 1712 0.482551480817997 2505 286520
SGTC_39 0986-0283 58.349 µM -0.045738615337313 0.490311375268924 no 1713 0.481759292706809 2512 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_827 3253-0474 693 µM -0.0485430060349281 0.489177151237769 no 1714 0.480641745480722 2496 5402065
SGTC_281 1672-3440 14.9 µM -0.0494866807505216 0.488795505189137 no 1715 0.480265725708326 2511 6833000
SGTC_171 k064-0041 9.68 µM -0.0498241273618132 0.488659035671724 no 1716 0.480131269851717 2497 53325
SGTC_3128 9127691 49.47 µM -0.0499535286349606 0.488606703806033 no 1717 0.480079710415712 2595 41316314
SGTC_3235 9132602 49.47 µM -0.0504065774654792 0.488423485440346 no 1718 0.479899197495973 2565 4912240
SGTC_2804 7954240 19.48 µM -0.0513414030734056 0.488045438548318 no 1719 0.479526738354181 2545 828705
SGTC_920 mycophenolic acid 780.421 nM -0.05184312188043 0.48784254603704 no 1720 0.479326847718989 2515 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_293 4049-0273 38.5 µM -0.0522247776062004 0.487688208524071 no 1721 0.479174795097402 2506 1380311
SGTC_2013 4024628 200 µM -0.0527964614077828 0.487457029136578 no 1722 0.478947040478906 2572 5230760
SGTC_1313 1220-0047 237 µM -0.0529040679251246 0.487413515325968 no 1723 0.478904171600952 2527 3528706
SGTC_99 0109-0120 622.8 µM -0.0534532649743939 0.487191433944191 no 1724 0.478685383262783 2507 759414
SGTC_1954 st077032 68.9 µM -0.0545669495864792 0.486741100350096 no 1725 0.4782417349604 2575 698907
SGTC_3250 9135583 49.47 µM -0.0557937703388915 0.486245038204105 no 1726 0.477753048882326 2611 7699353
SGTC_592 k241-0073 46.5 µM -0.0567103863122127 0.485874420495284 no 1727 0.47738795012596 2512 4230158
SGTC_843 0310-0051 143 µM -0.0573259688423257 0.485625527246334 no 1728 0.477142767109484 2527 2065037
SGTC_2881 9058953 51.95 µM -0.0574753915536676 0.485565113273174 no 1729 0.477083254195843 2504 17122249
SGTC_2469 5655019 90.81 µM -0.0590204472794981 0.484940442404973 no 1730 0.476467910962705 2651 2788239
SGTC_2303 7774051 200 µM -0.0605705911624607 0.484313751519078 no 1731 0.475850597678949 2569 2953184
SGTC_3282 9108498 15.4605 µM -0.0609727306283747 0.484151181175849 no 1732 0.475690463221516 2582 16459645
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0634584775029299 0.483146343735119 no 1733 0.474700711360616 2516 2724 A muscle relaxant with antifungal properties.
SGTC_1783 st039459 87.517 µM -0.0639513221726644 0.482947128892065 no 1734 0.474504493347586 2662 729761
SGTC_2133 5320837 200 µM -0.0641622410610789 0.482861873767816 no 1735 0.474420521342225 2581 2841355
SGTC_113 0099-0221 2.5 µM -0.0642310496879114 0.482834060932474 no 1736 0.47439312717847 2519 89219
SGTC_2185 6113692 200 µM -0.0646419292094738 0.482667982854118 no 1737 0.474229549910473 2581 874150
SGTC_888 0916-0002 6.97 µM -0.0654713997284556 0.482332718901708 no 1738 0.473899338587636 2688 2802138 YIL048W NEO1
SGTC_1550 gossypolone 36.6 µM -0.0662767078073761 0.482007233124074 no 1739 0.473578763460366 2532 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0669120962165914 0.481750433163335 no 1740 0.473325841616668 2508 279621
SGTC_2119 5528445 120.635 µM -0.0679395716877698 0.481335182512274 no 1741 0.472916868929113 2604 791935
SGTC_624 k048-0052 28 µM -0.0681353135681331 0.481256076392307 no 1742 0.472838959750401 2582 6835531
SGTC_1289 0976-0073 69.1 µM -0.0686062383832913 0.481065762281739 no 1743 0.472651526529036 2621 3391136
SGTC_2950 9072895 21.46 µM -0.0689232784918473 0.480937639785348 no 1744 0.47252534451027 2571 17332245
SGTC_2749 bexarotene 57.39 µM -0.069759479724272 0.480599722970245 no 1745 0.472192549532787 2565 82146 An retinoic acid receptor inhibitor.
SGTC_2846 9008642 19.48 µM -0.0700762579704172 0.480471713517043 no 1746 0.472066481815855 2630 2992898
SGTC_2766 oltipraz 83.91 µM -0.0702295537511066 0.480409767722112 no 1747 0.472005475950495 2568 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1587 estradiol valerate 56.1 µM -0.0702753356838587 0.480391267642385 no 1748 0.471987256617266 2540 13791 A steroid.
SGTC_1243 0416-0003 5.65 µM -0.0703815347062776 0.48034835370635 no 1749 0.471944993983819 2591 2141977
SGTC_2079 5212404 121 µM -0.0707114384451212 0.480215044443134 no 1750 0.471813708532494 2531 758462
SGTC_1090 efavirenz 20.7 µM -0.0709273237938274 0.480127809536299 no 1751 0.471727798445761 2564 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1031 k035-0009 16 µM -0.0715379923483596 0.479881055881194 no 1752 0.471484794239334 2560 5180959
SGTC_2608 thymoquinone 42.66 µM -0.0719361129888739 0.479720190890071 no 1753 0.471326375237369 2511 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3344 9148862 3.898 µM -0.0723955037667342 0.479534573137316 no 1754 0.47114358144098 2596 4905352
SGTC_3205 9113483 49.47 µM -0.0727904486241076 0.479374998432572 no 1755 0.470986435844174 2625 17018033
SGTC_1713 st033146 12.748 µM -0.0743464973834287 0.478746320237653 no 1756 0.470367339907691 2559 674619
SGTC_593 1203-0218 61.7 µM -0.0748662105388415 0.478536356303469 no 1757 0.470160580582467 2585 3666956
SGTC_1952 st077036 64.1 µM -0.0771872058559206 0.477598748523281 no 1758 0.469237309764457 2538 2937007
SGTC_2934 9036370 36.88 µM -0.0774175971265307 0.477505684507397 no 1759 0.469145671155862 2609 6462800
SGTC_998 3996-0085 177 µM -0.0777279670227271 0.477380315946985 no 1760 0.469022223467015 2589 715391
SGTC_1733 st037357 54.9 µM -0.0780527818211037 0.477249115015218 no 1761 0.468893033597885 2542 1272339 YGL099W LSG1
SGTC_2220 6782180 200 µM -0.0788114917803261 0.476942662459752 no 1762 0.468591281681196 2554 833803
SGTC_1253 0550-0034 176 µM -0.0797588423603162 0.476560034733013 no 1763 0.468214529515415 2609 5969915
SGTC_1409 3909-8004 61.9 µM -0.0828225615270504 0.475322771504336 no 1764 0.466996314626896 2592 2119279
SGTC_1191 1487-1166 10.6 µM -0.0828425228492569 0.47531471102028 no 1765 0.4669883784841 2660 3955771
SGTC_2328 6201408 200 µM -0.0847291180817401 0.474552940274454 no 1766 0.466238373158842 2610 2890418
SGTC_2642 cholecalciferol 100 µM -0.0865255369281981 0.473827667432081 no 1767 0.465524328329825 2576 9821465 A vitamin D precursor, similar to steriods.
SGTC_595 3909-8003 73.7 µM -0.0876326351185428 0.47338073885451 no 1768 0.465084331438915 2630 699517
SGTC_3342 9147791 14.508 µM -0.0879283425186344 0.473261369283234 no 1769 0.464966814884971 2557 1838168
SGTC_1685 st024049 53.0905 µM -0.0882053143893304 0.473149564947067 no 1770 0.464856746755633 2622 1941139
SGTC_2713 st079149 53.4 µM -0.0884651635097361 0.473044674418882 no 1771 0.464753485621443 2619 3103253
SGTC_964 1287-0107 19.4 µM -0.0886490074030819 0.472970465240099 no 1772 0.464680429547792 2640 51516812 YPR165W RHO1
SGTC_1336 1486-0901 104 µM -0.0886578437480565 0.472966898444641 no 1773 0.464676918181992 2638 5006114
SGTC_384 k007-0144 5.16 µM -0.0888603344947668 0.472885163539047 no 1774 0.46459645364385 2635 6824886
SGTC_1560 lithocholic acid 53.1 µM -0.0896911916357468 0.472549802031233 no 1775 0.464266307893321 2568 9903 A bile acid which acts as a detergent.
SGTC_3297 9117502 71.43 µM -0.0902654489122944 0.472318024099724 no 1776 0.464038137904311 2548 7453720
SGTC_1003 4049-0218 100 µM -0.0906773514909495 0.472151780468157 no 1777 0.463874483684783 2660 295161
SGTC_2261 9010538 184.68 µM -0.0913394847879136 0.471884554049775 no 1778 0.463611422387855 2684 6457250
SGTC_2706 st078239 82.5 µM -0.0917811281536062 0.471706320873188 no 1779 0.463435969158969 2578 15434492
SGTC_3228 9131799 49.47 µM -0.0926721275706419 0.471346759209613 no 1780 0.463082020337081 2613 17015818
SGTC_2777 climbazole 1.536 µM -0.0935821319635403 0.470979552221632 no 1781 0.462720551971754 2575 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1961 st076550 68.7 µM -0.0935845503679286 0.470978576374471 no 1782 0.462719591383555 2668 1579337
SGTC_2244 6635614 200 µM -0.0942631525980881 0.470704761390921 no 1783 0.462450059755538 2566 836499
SGTC_1794 st048918 76.9 µM -0.0949845343763332 0.470413700113374 no 1784 0.462163555577608 2547 672303
SGTC_3161 9100388 49.47 µM -0.0968971727057755 0.469642070604877 no 1785 0.46140402704854 2590 25236368
SGTC_2055 5235184 200 µM -0.0972227040586066 0.469510750410388 no 1786 0.461274769110759 2674 2836034
SGTC_547 1120-0019 610 nM -0.0982421377996838 0.469099529707873 no 1787 0.460870011576423 2567 3676939
SGTC_2910 7948405 25.97 µM -0.0988729263174865 0.468845097774613 no 1788 0.460619582611001 2626 2971328
SGTC_688 0527-0193 473 µM -0.0992923813340667 0.468675915379898 no 1789 0.460453063670034 2630 4007154
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.0999816579293427 0.468397915829023 no 1790 0.460179443661321 2566 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1149 3909-7961 23.3 µM -0.100407691264748 0.468226095443133 no 1791 0.460010331940201 2600 735261
SGTC_2050 5263056 171 µM -0.100860965509895 0.468043295224539 no 1792 0.45983041502461 2625 763468 YGL055W OLE1
SGTC_2068 5226020 147 µM -0.102020647098815 0.467575639923118 no 1793 0.459370143287989 2612 1810509
SGTC_3306 9127676 59.7925 µM -0.104496117962284 0.466577527574692 no 1794 0.458387824416353 2650 41905287
SGTC_2171 5739187 198.077 µM -0.104871228357353 0.466426300865554 no 1795 0.458238994746785 2574 2262761
SGTC_3063 1327-0034 4 µM -0.104882760226093 0.466421651840047 no 1796 0.458234419428475 2590 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_216 k038-0035 28.382 µM -0.106308883710916 0.465846751533373 no 1797 0.457668641676542 2568 4444231 YPR107C YTH1
SGTC_2921 7974240 10.71 µM -0.10637099770428 0.465821713689943 no 1798 0.457644001490854 2692 2979074 YDR527W RBA50
SGTC_2377 9073351 62.6 µM -0.106846752211489 0.465629943895474 no 1799 0.457455278419167 2584 7337946 YHR072W ERG7
SGTC_1172 0370-0043 85 µM -0.108295499574259 0.465046024026383 no 1800 0.456880646220812 2733 376585
SGTC_1085 doxorubicin 7.67 µM -0.108481803984745 0.464970939180015 no 1801 0.456806756821824 2622 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3095 9117207 49.47 µM -0.108764977985919 0.464856816110388 no 1802 0.45669445124767 2603 17015229
SGTC_2000 st075254 36.4 µM -0.108857092833993 0.46481969316529 no 1803 0.456657919645718 2602 17234175
SGTC_1615 st002656 86.5 µM -0.109733919914889 0.464466340932267 no 1804 0.456310199324129 2573 1584458
SGTC_496 calpeptin 138 µM -0.109991884975311 0.464362389006897 no 1805 0.456207905358274 2679 73364 A calpain inhibitor.
SGTC_3233 9132340 49.47 µM -0.110755859975021 0.464054545053229 no 1806 0.455904974280771 2608 17682950
SGTC_994 3910-0338 138 µM -0.110780621296597 0.464044567830358 no 1807 0.45589515635881 2726 3479481
SGTC_2181 6316240 54.2555 µM -0.111195833283297 0.463877267430527 no 1808 0.455730527851029 2676 12779990
SGTC_2674 ligustilide 100 µM -0.112038630641403 0.463537700723416 no 1809 0.455396388280478 2687 5319022 A signalling regulator.
SGTC_287 k060-0039 29.6 µM -0.112238937475451 0.46345700012965 no 1810 0.455316978283023 2690 5861974
SGTC_3217 9129673 49.47 µM -0.113602637093471 0.462907626316558 no 1811 0.45477639839453 2725 17248312
SGTC_2518 prenyletin 46.28 µM -0.113794591736897 0.462830301999134 no 1812 0.454700312956781 2638 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1655 st012546 55.1 µM -0.113853598380567 0.462806532872139 no 1813 0.454676924711763 2696 720985 YLR208W SEC13
SGTC_1158 4092-0494 91.8 µM -0.11398444717109 0.462753824679236 no 1814 0.454625061221477 2739 1148199
SGTC_869 0564-0080 44.1 µM -0.114870559182751 0.462396900440733 no 1815 0.454273860479526 2657 6843321
SGTC_1700 st030840 7.9285 µM -0.116663678715573 0.461674728211472 no 1816 0.453563286930491 2712 5499307
SGTC_2821 7996764 71.43 µM -0.116910741170707 0.461575234575619 no 1817 0.453465393152033 2727 2987135
SGTC_706 4262-0057 46.9 µM -0.117077034283319 0.461508268625846 no 1818 0.453399504274411 2596 883298
SGTC_2545 solidagenone 89.61 µM -0.119562544872964 0.460507488897201 no 1819 0.452414845841137 2589 6708572 An anti ulcer agent
SGTC_2593 nobiletin 86.24 µM -0.119808149521896 0.460408610758159 no 1820 0.452317563031659 2695 72344 An anti-infammatory.
SGTC_3131 9127911 49.47 µM -0.1223662201042 0.459378902088372 no 1821 0.451304494940319 2827 45595681
SGTC_345 1362-0200 395 µM -0.123179085200999 0.459051753506586 no 1822 0.450982643510579 2640 1419823
SGTC_2923 7992654 58.14 µM -0.124718248401174 0.458432372543681 no 1823 0.450373305033555 2656 2985126
SGTC_2179 6298986 200 µM -0.124833482371288 0.458386004811889 no 1824 0.450327689808562 2714 738374
SGTC_674 0498-0004 451 µM -0.125676234765139 0.458046916184618 no 1825 0.449994107298078 2651 4231473
SGTC_1375 2910-0797 186 µM -0.127076728462809 0.457483483223359 no 1826 0.449439835058373 2711 742508
SGTC_1787 fluconazole 80 µM -0.127497669992726 0.457314150781902 no 1827 0.449273258604871 2659 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_462 ag-879 158 µM -0.128895562462139 0.456751875373193 no 1828 0.448720144010639 2710 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_451 chloral hydrate 100 µM -0.132081935093244 0.455470543515185 no 1829 0.447459742212246 2743 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.132520039923638 0.455294404904786 no 1830 0.447286486622113 2720 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_34 0469-0683 81.75 µM -0.132950879099245 0.45512119599727 no 1831 0.447116114161346 2723 3690923
SGTC_1913 st060213 96.1 µM -0.13310446009814 0.455059454376249 no 1832 0.447055383943724 2722 688959
SGTC_1679 SEC14.276 6.7 µM -0.133248518783821 0.455001541839493 no 1833 0.44699842024313 2803 1005053 YMR079W SEC14
SGTC_2188 6126565 140.678 µM -0.133508329222655 0.454897098757094 no 1834 0.44689568873725 2683 874518
SGTC_534 k292-0788 63.4 µM -0.133906862732077 0.454736895443313 no 1835 0.446738111744249 2624 4146317
SGTC_3348 9149464 3.537 µM -0.135651957701133 0.454035485643204 no 1836 0.446048214369567 2614 1951442
SGTC_3163 9099914 49.47 µM -0.135736373190962 0.454001559959311 no 1837 0.446014846083606 2673 16268368
SGTC_2995 9067767 71.4286 µM -0.135899103397318 0.453936161374463 no 1838 0.445950522142883 2725 11673567
SGTC_2107 5363541 170.161 µM -0.136636554809736 0.453639807500465 no 1839 0.445659040453546 2650 244052
SGTC_79 0052-0007 94.094 µM -0.137228606624433 0.453401902906693 no 1840 0.445425049994197 2776 2801472
SGTC_375 3970-0961 9.27 µM -0.137428130241626 0.453321731955456 no 1841 0.445346198636182 2709 2898222
SGTC_897 1000-0139 31.4 µM -0.138671677925152 0.452822102780693 no 1842 0.444854799783981 2750 6151020
SGTC_333 3486-0131 40.1 µM -0.139367795136451 0.452542451272153 no 1843 0.444579759862373 2796 6744690
SGTC_910 3454-3003 490 µM -0.140700116223613 0.452007283026288 no 1844 0.444053426638094 2659 820824
SGTC_3037 9091026 49.47 µM -0.142716419726988 0.451197538085412 no 1845 0.443257074199932 2717 25236398 YIL048W NEO1
SGTC_1257 0669-0121 16 µM -0.143726920284519 0.450791798502305 no 1846 0.44285805629503 2766 4307855
SGTC_1472 k841-0093 193 µM -0.143744265727371 0.450784834349385 no 1847 0.442851207578146 2766 X1472
SGTC_2759 disulfiram 3.38 µM -0.144300576997234 0.450561484781047 no 1848 0.442631561349438 2665 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3082 9117008 49.47 µM -0.144662946655152 0.450416007906069 no 1849 0.442488497816631 2705 41448529
SGTC_3242 9133940 49.47 µM -0.145615638606794 0.450033572150803 no 1850 0.442112410879148 2818 17248444
SGTC_1234 0326-0494 15.5 µM -0.146326519865455 0.449748235812769 no 1851 0.441831815674481 2786 1547813
SGTC_2093 5331342 194.4 µM -0.146336532119672 0.449744217239658 no 1852 0.441827863899764 2771 33839
SGTC_2621 lithochol-11-enic acid 100 µM -0.146343189251931 0.449741545299498 no 1853 0.441825236374104 2658 6708711
SGTC_833 3852-0053 558 µM -0.146886055722727 0.449523665356152 no 1854 0.441610979228084 2812 3123681
SGTC_3019 9081971 49.47 µM -0.14737918088385 0.449325762319675 no 1855 0.44141636866067 2790 16451803
SGTC_1298 1079-1278 263 µM -0.147521553836004 0.449268626958391 no 1856 0.441360184172997 2691 2840950
SGTC_1827 berberine 7.24 µM -0.148215259573208 0.448990252578307 no 1857 0.441086444713812 2671 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_900 1112-0045 141 µM -0.148447882136482 0.448896910021921 no 1858 0.44099465708032 2699 56211 YIL048W NEO1
SGTC_2385 9074692 200 µM -0.148954863235842 0.44869348766266 no 1859 0.440794624724867 2702 17046906
SGTC_641 4092-0595 30 µM -0.149019656577394 0.448667490791802 no 1860 0.440769061220873 2719 786260
SGTC_921 1561-0023 372 µM -0.149220421790511 0.448586939666024 no 1861 0.440689853070406 2649 24050882
SGTC_1186 1319-0216 26 µM -0.15102713487186 0.44786214503163 no 1862 0.439977155435744 2844 4565136
SGTC_1465 k213-0056 144 µM -0.153371015089722 0.446922116073086 no 1863 0.439052850520762 2663 24048857 YMR208W ERG12
SGTC_690 glyoxal 20.3 µM -0.155768230348483 0.445961005151527 no 1864 0.438107856705528 2694 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.155969718945653 0.445880237097675 no 1865 0.43802844492818 2735 4330530
SGTC_1840 st055363 71 µM -0.156330988292779 0.445735425485307 no 1866 0.437886065746949 2730 676033
SGTC_2364 9055074 200 µM -0.156770057830542 0.445559438103729 no 1867 0.437713035705965 2769 6470630
SGTC_2125 5246583 200 µM -0.157445098114415 0.445288890115538 no 1868 0.437447036739939 2721 835267
SGTC_2270 7924575 90.91 µM -0.158881738352291 0.44471318703919 no 1869 0.436881024304974 2912 1262135
SGTC_3298 9116858 71.43 µM -0.161075250508502 0.443834408943631 no 1870 0.436017066462118 2809 2506942
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.161800905274707 0.443543753311983 no 1871 0.435731320065593 2788 616764
SGTC_1063 disulfiram 1.84 µM -0.161876372409171 0.443513527252092 no 1872 0.435701604742244 2667 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1906 st060206 94.7 µM -0.161995501259336 0.443465814492041 no 1873 0.43565469827669 2806 5133468
SGTC_273 hydroxyurea 18.1 mM -0.162306696931229 0.443341180169386 no 1874 0.435532170609659 2698 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1811 st050069 61.5 µM -0.163023518295207 0.443054113507988 no 1875 0.435249958727719 2692 3877702
SGTC_1657 st012939 43.4 µM -0.163388440368627 0.44290798402085 no 1876 0.435106301916618 2835 24207257
SGTC_2326 6164455 177.58 µM -0.163783422834856 0.442749825894546 no 1877 0.434950821053609 2771 2888790
SGTC_2549 cedrol 20.94 µM -0.163798238119622 0.442743893763807 no 1878 0.434944989361785 2826 6708665 A sedative which affects the nervous system.
SGTC_1392 3455-1037 33.9 µM -0.164696435363203 0.442384274114811 no 1879 0.43459146141765 2836 981132
SGTC_2401 5128683 200 µM -0.165157256359946 0.442199789300042 no 1880 0.434410103830822 2740 708373
SGTC_1039 k821-0043 94 µM -0.167452449809213 0.441281120335989 no 1881 0.433507029367785 2843 15992768
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.167490231771461 0.441266000441684 no 1882 0.433492166441534 2701 16623 A steroid.
SGTC_508 roscovitine 141 µM -0.168917669993491 0.440694819458916 no 1883 0.432930700136626 2704 160355 A CDKinase inhibitor.
SGTC_2853 9015042 58.44 µM -0.169358685427912 0.440518374624004 no 1884 0.43275725913889 2682 6457456
SGTC_1607 st000305 50.6 µM -0.170658101179815 0.439998563201046 no 1885 0.432246304921319 2861 5457690
SGTC_1714 st033236 13.627 µM -0.170690887815496 0.439985448742022 no 1886 0.432233414073878 2836 2916566
SGTC_537 1334-0398 209 µM -0.170918205845321 0.439894524695464 no 1887 0.432144040556016 2746 5846986
SGTC_1323 1348-1351 11.2 µM -0.172608414728923 0.439218564407807 no 1888 0.431479618593115 2728 6989654
SGTC_2452 5863136 48.41 µM -0.172698923931572 0.43918237230862 no 1889 0.431444044830748 2683 2184096
SGTC_1111 tnp00062 510.699 nM -0.174192339313354 0.438585270882833 no 1890 0.430857152921741 2849 676306
SGTC_3122 9126309 49.47 µM -0.175666783001042 0.437995891867206 no 1891 0.430277866383393 2708 17591206
SGTC_1886 st057356 49.9 µM -0.175734198413614 0.437968947198416 no 1892 0.430251383468598 2689 24207747
SGTC_2564 betulinic acid 100 µM -0.176482525420393 0.437669874351173 no 1893 0.42995743795452 2957 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3043 9092303 49.47 µM -0.17684304602157 0.437525803083673 no 1894 0.429815838023681 2745 25236084
SGTC_166 k072-0058 166.424 µM -0.177004088713594 0.437461449867098 no 1895 0.429752588981186 2733 5846229
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.177262522434455 0.437358182316936 no 1896 0.429651093667969 2836 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2226 7298446 200 µM -0.177408545081677 0.437299835002531 no 1897 0.429593747888531 2768 3283010
SGTC_725 1497-0963 19 µM -0.177739669317016 0.437167530375501 no 1898 0.429463714816427 2826 3549977
SGTC_2514 salinomycin 42.74 µM -0.177879487044292 0.437111666648392 no 1899 0.429408810445073 2875 23682228 A polyether potassium ionophore.
SGTC_2807 7945238 51.95 µM -0.178299898931581 0.436943699977101 no 1900 0.429243729091387 2828 17148797
SGTC_2004 4023728 41.89 µM -0.178468117574562 0.436876494960936 no 1901 0.429177678854462 2812 360084 YDR527W RBA50
SGTC_2992 9074591 71.4286 µM -0.179766532504628 0.436357826758248 no 1902 0.428667929366129 2753 17741321
SGTC_2199 6590217 200 µM -0.179868781744115 0.436316986646914 no 1903 0.428627792003834 2777 703109
SGTC_145 3737-0113 38.366 µM -0.180330469193874 0.436132589169312 no 1904 0.428446568396736 2843 6849351
SGTC_3218 9131285 49.47 µM -0.183378913204832 0.43491539412295 no 1905 0.427250360068153 2829 17156417
SGTC_1057 3448-5381 134 µM -0.183939120883822 0.434691778857701 no 1906 0.427030607173885 2872 5497911
SGTC_2248 tofa 1.1 µM -0.184838636635257 0.434332767435871 no 1907 0.426677801160234 2718 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1312 1218-2183 165 µM -0.184894292713005 0.434310555962468 no 1908 0.426655973784549 2714 6744073
SGTC_1634 st006576 41 µM -0.186014957969773 0.433863360139585 no 1909 0.426216515641713 2878 3915356
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.186977768600561 0.433479222982903 no 1910 0.425839031812921 2727 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_544 k015-0020 52.4 µM -0.187101191268363 0.433429984987314 no 1911 0.425790647077943 2767 3008304
SGTC_3173 9105693 49.47 µM -0.189048029196372 0.432653454477949 no 1912 0.425027586788133 2895 17096658
SGTC_3313 9133968 57.047 µM -0.189209815157936 0.432588934966073 no 1913 0.424964187614456 2716 1494643
SGTC_128 0906-2981 13.371 µM -0.190470053417939 0.432086419289674 no 1914 0.424470403759932 2884 6740226
SGTC_3088 9117578 49.47 µM -0.191967422830874 0.431489491248055 no 1915 0.423883861806909 2752 678341
SGTC_2142 5622915 118.518 µM -0.192218981480923 0.431389222412576 no 1916 0.423785339033021 2776 5322196
SGTC_2941 9056145 11.23 µM -0.192830564696042 0.431145469733524 no 1917 0.423545832765158 2710 2119517
SGTC_1504 k297-0033 30 µM -0.1930183004147 0.431070651019064 no 1918 0.423472317963499 2702 4388117
SGTC_675 1309-0189 238 µM -0.193261042702088 0.430973914087203 no 1919 0.423377267273057 2787 4246530
SGTC_783 0848-0141 92.7 µM -0.193668729475844 0.430811453291685 no 1920 0.423217639242885 2727 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2756 carbadox 75.1 µM -0.194158248253041 0.430616398392246 no 1921 0.423025986892099 2786 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_885 0865-0106 16.8 µM -0.194316718933727 0.430553257385358 no 1922 0.422963947659915 2748 2793380
SGTC_1929 genistein trimethyl ether 50.5 µM -0.195758943995049 0.429978699498118 no 1923 0.422399423101676 2890 136420
SGTC_923 1900-2434 73.3 µM -0.196262810704515 0.429778002469344 no 1924 0.422202234016358 2732 5910570
SGTC_2689 tacrolimus 100 µM -0.198066168281322 0.429059849427324 no 1925 0.421496647111685 2846 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2339 9000433 200 µM -0.198528985177648 0.428875579115074 no 1926 0.421315604577832 2829 2988954
SGTC_1488 4013-0813 75.9 µM -0.200426409336673 0.428120283121197 no 1927 0.420573553420129 2765 2910057
SGTC_280 3448-3607 3.04 µM -0.200848808648934 0.427952176948072 no 1928 0.420408398352098 2837 626179
SGTC_2546 rhodinyl acetate 100 µM -0.201162562217001 0.427827317991701 no 1929 0.420285732049349 2772 6708682
SGTC_1845 st056753 3.01 µM -0.201937243251869 0.427519062861976 no 1930 0.419982892950403 2704 5375839
SGTC_2123 5259487 200 µM -0.202388622430308 0.42733947391147 no 1931 0.419806461173304 2887 2173474
SGTC_720 r052-1644 49.9 µM -0.204059930113267 0.426674646840411 no 1932 0.419153333293336 2879 1422863 YOR257W CDC31
SGTC_3258 9138477 49.47 µM -0.20420367615833 0.426617476008612 no 1933 0.419097169363323 2788 4970355
SGTC_1721 st082152 9.2685 µM -0.204884295587687 0.426346800268441 no 1934 0.418831262625856 2738 5296051
SGTC_2439 5492030 7.2 µM -0.205699762021556 0.42602254287323 no 1935 0.418512722231849 2884 5722370
SGTC_2850 9015429 58.44 µM -0.207882413736034 0.42515489241803 no 1936 0.417660390507272 2837 6457570
SGTC_1453 4237-0541 195 µM -0.208678118354404 0.424838672834961 no 1937 0.417349761548448 2874 739892
SGTC_2279 7948423 32.93 µM -0.20891428177107 0.424744828841356 no 1938 0.417257577459289 2945 1247112
SGTC_284 0988-0104 32.6 µM -0.209161479756576 0.424646604622207 no 1939 0.417161091005537 2874 4666532
SGTC_574 1315-0397 40 µM -0.209282934475374 0.424598346254573 no 1940 0.417113686560154 2767 6794277
SGTC_3077 9117319 49.47 µM -0.21094807251879 0.423936840745598 no 1941 0.416463895801113 2753 17154678
SGTC_809 3998-0021 90 µM -0.211147724036155 0.423857540001606 no 1942 0.416386000604415 2926 715485
SGTC_1916 st067606 49.2 µM -0.212707335307606 0.423238175318336 no 1943 0.415777622473008 2888 19590279
SGTC_449 xestospongin c 11.1929 µM -0.21337434268585 0.422973346086926 no 1944 0.415517495633258 2907 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_389 tpck 16.7 µM -0.213563266974053 0.422898341731219 no 1945 0.415443823593849 2855 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1565 sinapyl alcohol 95.1 µM -0.214628801048821 0.422475369140718 no 1946 0.415028368597303 2863 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2437 5741531 144.16 µM -0.214922155724023 0.422358935238907 no 1947 0.414914005370546 2962 2262990
SGTC_1292 0kpi-0043 232 µM -0.21711511167078 0.421488755920623 no 1948 0.414059318720307 2843 3333905
SGTC_938 3126-1755 342 µM -0.217748703735173 0.421237413609065 no 1949 0.413812456973744 2936 1777771
SGTC_1489 4065-0444 182 µM -0.219843747298112 0.420406550979446 no 1950 0.412996423786791 2878 2877968
SGTC_3301 9125354 19.7965 µM -0.219990074681617 0.420348532952077 no 1951 0.412939442312291 2775 41905162
SGTC_370 0180-0345 38.7 µM -0.220787771891409 0.420032280724567 no 1952 0.412628842628731 2723 3989527
SGTC_683 panaxydol 45 µM -0.224218956549112 0.418672556448464 no 1953 0.411293466882908 2843 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_806 3966-4455 5.86 µM -0.22429005090612 0.418644393091097 no 1954 0.411265808623613 2800 714982
SGTC_822 1487-0950 154 µM -0.224486200964452 0.41856669226278 no 1955 0.411189501490642 2896 1958375
SGTC_2229 7354935 190 µM -0.225213939024855 0.418278441518569 no 1956 0.410906423103638 2880 318112
SGTC_411 enrofloxacin 100 µM -0.225777165016374 0.418055382697163 no 1957 0.410687369101231 2962 71188 A bacterial gyrase inhibitor.
SGTC_2776 terbinafine 19.92 µM -0.225872435584944 0.41801765454838 no 1958 0.410650318522203 2797 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3174 9107204 49.47 µM -0.226877566985262 0.417619657957267 no 1959 0.410259473091167 2929 3938802
SGTC_2208 7283366 200 µM -0.226997184194765 0.417572299370275 no 1960 0.410212965855634 2890 898663
SGTC_3327 9140648 26.9345 µM -0.227051495062015 0.417550797123732 no 1961 0.410191850177972 2939 8029710
SGTC_3039 9090270 49.47 µM -0.22766031289467 0.417309776592886 no 1962 0.409955163981986 2881 17173750
SGTC_1675 st018485 24.5 µM -0.229246132820724 0.416682123773085 no 1963 0.409338809173189 2883 3323024
SGTC_1322 1348-1070 12 µM -0.229532452022333 0.416568823872358 no 1964 0.409227550373325 2803 6758089
SGTC_925 2064-1272 59.6 µM -0.232093717286608 0.415555610239685 no 1965 0.408232612270279 2846 6815817
SGTC_2805 7950783 58.44 µM -0.234391420270335 0.414647136795224 no 1966 0.407340559392366 2935 1178958 YDL195W SEC31
SGTC_621 3584-0052 32.1 µM -0.234776336136419 0.414494991975984 no 1967 0.407191167732977 2877 2273927
SGTC_1368 1852-0141 284 µM -0.235040044215703 0.414390764086311 no 1968 0.407088826437055 2926 2838987
SGTC_2048 5246248 200 µM -0.235661969475991 0.414144978447196 no 1969 0.406847491360117 2910 677046
SGTC_2781 5567276 71.43 µM -0.236943726109358 0.413638532777812 no 1970 0.406350223581926 2995 2853274
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.237757477504595 0.413317079086394 no 1971 0.406034600508894 2840 4174840
SGTC_1303 1160-0052 261 µM -0.23918416470239 0.412753639607002 no 1972 0.40548139054482 2845 3562476
SGTC_328 k915-0120 63.5 µM -0.239728370586098 0.412538764461799 no 1973 0.40527041980689 2955 6624543
SGTC_2337 9009472 200 µM -0.239948987963234 0.412451662996696 no 1974 0.405184901536258 3013 5742383
SGTC_931 2812-0076 566 µM -0.241107191846112 0.411994465875775 no 1975 0.404736019449422 2809 3450959
SGTC_1438 4092-1045 4 µM -0.242712434222503 0.411360999390792 no 1976 0.404114087161855 2835 1351342
SGTC_2051 5263410 176 µM -0.243379983412241 0.411097636657703 no 1977 0.403855524311413 2853 227584
SGTC_871 0574-0004 149 µM -0.244860460107208 0.41051369938897 no 1978 0.403282239041736 2841 9551173
SGTC_2351 9026858 72.31 µM -0.245119659437422 0.410411485012713 no 1979 0.403181890576612 2821 1409300
SGTC_506 n9-isopropylolomoucine 153 µM -0.245449059309111 0.410281596072437 no 1980 0.40305437332244 2984 6610355
SGTC_1514 1189-1591 158 µM -0.246456961146314 0.409884221457098 no 1981 0.402664258526034 3055 767698 YMR146C TIF34
SGTC_138 0850-0259 40.9225 µM -0.247021963950186 0.409661504328837 no 1982 0.40244561296699 2930 6813004
SGTC_2180 6301957 200 µM -0.247299813269247 0.409551990245197 no 1983 0.402338101645272 2949 845462
SGTC_1141 3253-0389 52.6 µM -0.248965398340203 0.408895649476493 no 1984 0.401693773461812 2913 5402031
SGTC_269 exalamide 29 µM -0.250176026777361 0.40841874916611 no 1985 0.401225611872531 2869 3316 A derivative of salicylamide.
SGTC_1469 k284-2957 126 µM -0.251106050522586 0.408052478927895 no 1986 0.400866059054847 2892 23884841
SGTC_1597 7-benzyloxygramine 47.5 µM -0.251283220028142 0.407982713554058 no 1987 0.400797573761538 2837 260807
SGTC_1737 st035557 69.7 µM -0.251722864932083 0.407809603867123 no 1988 0.400627641153756 2780 5716916
SGTC_270 tamoxifen 5.46 µM -0.253298481161242 0.407189354799582 no 1989 0.400018784852525 3048 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1434 4073-0095 163 µM -0.254158543438224 0.40685088511901 no 1990 0.399686538353388 2877 24133745
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.254420258261851 0.406747903425581 no 1991 0.399585450965845 2952 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1944 st076371 56.9 µM -0.256749362516361 0.405831713225843 no 1992 0.398686131354166 2860 24208455
SGTC_263 alizarin 107.927 µM -0.257401074096306 0.405575444207514 no 1993 0.398434586902944 2871 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_987 1497-1013 404 µM -0.259919686205703 0.404585445330301 no 1994 0.397462862816396 2849 1676435
SGTC_81 0411-0046 9.971 µM -0.26074881168026 0.404259671606421 no 1995 0.397143110725464 2855 12925265
SGTC_180 1486-1293 102.781 µM -0.261398786625489 0.404004334757361 no 1996 0.39689249632558 2962 4140536
SGTC_2936 9038235 15.59 µM -0.261851313253573 0.403826587856328 no 1997 0.39671803828921 2844 4749415
SGTC_3144 9087057 49.47 µM -0.263276495415408 0.403266923725861 no 1998 0.396168737375657 2923 17249618
SGTC_1559 coumarin 343 70.1 µM -0.263854472231443 0.403040010606478 no 1999 0.3959460293016 3030 108770 A hepatotoxic, DNA x-linker.
SGTC_3006 9075424 71.4286 µM -0.264674976314877 0.402717937614311 no 2000 0.395629928104681 2903 7465181
SGTC_1920 st075728 45.7 µM -0.264755207065601 0.402686448125725 no 2001 0.395599022693319 3078 3400306
SGTC_2076 5212012 200 µM -0.265385351019233 0.402439147081248 no 2002 0.395356309950415 2830 604802
SGTC_1442 4112-3290 3 µM -0.265427301960637 0.40242268474932 no 2003 0.395340153133164 2880 704353
SGTC_1999 st074831 12.5 µM -0.265655503529579 0.402333137228644 no 2004 0.395252267648255 2898 17112523
SGTC_1596 piperlongumine 63 µM -0.265728856955411 0.402304354038836 no 2005 0.395224018748559 3031 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2822 7994718 71.43 µM -0.267069227768126 0.401778498644388 no 2006 0.394707929995401 2808 1018011
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.269289538089288 0.400907816229925 no 2007 0.393853441161681 3011 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2354 9060492 162 µM -0.269347054112642 0.400885268158406 no 2008 0.393831312827647 3024 6471895
SGTC_836 0330-0104 1.35 µM -0.269859832435506 0.40068425769665 no 2009 0.393634045050438 2890 46494820
SGTC_3085 9117376 49.47 µM -0.270239842840792 0.400535309572074 no 2010 0.393487871204569 2961 16480349
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.270407577267394 0.400469569318387 no 2011 0.393423355676106 2825 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_144 4161-2749 112.381 µM -0.27177164879753 0.399935052805191 no 2012 0.392898802984047 2898 797501 YMR168C CEP3
SGTC_2790 5423970 71.43 µM -0.272457052508226 0.399666545493132 no 2013 0.392635304830092 3071 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_61 0978-8327 98.565 µM -0.272669879637902 0.399583179985174 no 2014 0.392553495092176 2949 6150059 YHR072W ERG7
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.272775595064102 0.399541772397235 no 2015 0.392512860348911 2943 4213774
SGTC_630 4356-0227 183 µM -0.272791430954912 0.399535569747545 no 2016 0.392506773472909 2898 779312
SGTC_1895 st058434 18.3 µM -0.273021408157876 0.399445494438677 no 2017 0.392418379596637 3058 5393175
SGTC_1330 1469-0054 61.8 µM -0.273114581538543 0.399409002688078 no 2018 0.392382569120959 3035 7102664
SGTC_3294 9122953 26.2835 µM -0.273531675560446 0.399245656818435 no 2019 0.392222273400472 2865 16459826
SGTC_2143 5623677 140.463 µM -0.2737173366013 0.399172952351316 no 2020 0.392150926854687 2884 5375313
SGTC_3259 9138485 49.47 µM -0.274181936551706 0.398991031334283 no 2021 0.391972404474889 3188 17646153
SGTC_3254 9136651 49.47 µM -0.274434084825282 0.398892308111154 no 2022 0.391875526100094 2920 16454030
SGTC_755 1995-0008 37.3 µM -0.274969701456479 0.398682620430313 no 2023 0.391669758051735 2972 689533
SGTC_2416 tofa 880 nM -0.275087737223615 0.398636414730667 no 2024 0.391624416278326 2905 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3231 9132313 49.47 µM -0.275246694393742 0.398574192385401 no 2025 0.391563357452141 2949 4905967
SGTC_3151 9099821 49.47 µM -0.275770743513676 0.398369076370317 no 2026 0.391362077980327 3017 17174189
SGTC_3253 9135987 49.47 µM -0.27635092807825 0.398142021350856 no 2027 0.391139271648048 3008 4182430
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.277502690351248 0.39769138185687 no 2028 0.390697070154195 2918 688664
SGTC_2977 9011197 71.43 µM -0.277647885582648 0.397634582321378 no 2029 0.390641334686568 3108 2704722
SGTC_2441 5730946 39.09 µM -0.27895902587083 0.397121770233785 no 2030 0.390138134799707 3021 1774275
SGTC_98 0074-0023 107.663 µM -0.2801874591958 0.396641467741526 no 2031 0.389666843804801 2976 3563821
SGTC_3166 9102297 49.47 µM -0.280922774796783 0.396354043245285 no 2032 0.389384816002627 2950 25237072
SGTC_3027 9089541 49.47 µM -0.281811032567757 0.396006910936384 no 2033 0.389044205449126 3001 9943819
SGTC_1016 4226-1401 38 µM -0.28215521286808 0.395872426969267 no 2034 0.388912249272737 2874 2901613
SGTC_1856 st057054 55.7 µM -0.28238007064588 0.395784573415455 no 2035 0.388826047386654 3141 1266018
SGTC_2015 5119600 184 µM -0.282940610265584 0.395565589605722 no 2036 0.388611181737083 3093 2828786
SGTC_2499 avocadenofuran 51.48 µM -0.283057820119654 0.395519803857918 no 2037 0.388566257244355 2891 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3052 9092717 49.47 µM -0.283608912897153 0.395304549531 no 2038 0.388355052982247 3076 25237534
SGTC_1002 4049-0206 172 µM -0.284132311754545 0.39510014189481 no 2039 0.388154492872496 2899 4662749
SGTC_300 r073-0011 5.04 µM -0.285312442265243 0.394639360966523 no 2040 0.387702390649598 2976 2735780
SGTC_2332 7982454 138.89 µM -0.285812575034075 0.394444128984242 no 2041 0.38751083811849 2987 2981748
SGTC_825 1988-2224 89.6 µM -0.286209121157308 0.394289351958441 no 2042 0.387358979079058 2900 1180859
SGTC_454 lyso-paf C-16 6.67 µM -0.286596626168989 0.394138119917653 no 2043 0.387210599021287 2993 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_705 1124-0212 310 µM -0.288055489684825 0.393568910842436 no 2044 0.386652131618351 3051 9554485
SGTC_3123 9126162 49.47 µM -0.288318298625786 0.393466394037978 no 2045 0.386551550662999 2891 25239884
SGTC_1756 st041558 35.5 µM -0.288504359870299 0.393393819525024 no 2046 0.386480346818756 3109 3955792
SGTC_511 blebbistatin 171 µM -0.289787029235947 0.392893606117218 no 2047 0.385989585736618 3046 3476986 A myosin inhibitor.
SGTC_1821 st053465 65.6 µM -0.289835857946811 0.392874567460967 no 2048 0.385970907022229 2989 675086
SGTC_414 piperonyl butoxide 100 µM -0.290600355017722 0.392576518144757 no 2049 0.385678494262803 2917 5794 A potent inhibitor of cytochrome P450.
SGTC_971 1315-0384 26.7 µM -0.290764212810423 0.392512644203716 no 2050 0.385615828684616 2939 6769120
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.29107972884123 0.392389660026044 no 2051 0.385495171521912 3185 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1980 st071811 45.7 µM -0.291175627689102 0.392352281991126 no 2052 0.385458500832883 3068 4974850
SGTC_941 3237-0776 460 µM -0.291195030412164 0.392344719605408 no 2053 0.385451081564593 3121 760008
SGTC_1237 0330-0133 46.1 µM -0.292878236561801 0.391688829917014 no 2054 0.384807612252245 2902 X1237 YHR072W ERG7
SGTC_3184 9108758 49.47 µM -0.294305694635817 0.391132837858235 no 2055 0.384262160781209 2864 902885
SGTC_360 0957-0399 1.01 µM -0.294635684347938 0.391004339135966 no 2056 0.384136099714275 3064 6752301 YPR165W RHO1
SGTC_13 0199-0087 65 µM -0.294766831902795 0.390953273291929 no 2057 0.384086002765044 2914 4589825
SGTC_3331 9141060 1.957 µM -0.295357708370433 0.390723222904361 no 2058 0.383860318366917 2922 4906567 YPR165W RHO1
SGTC_482 fipronil 114 µM -0.301953048015502 0.388158022811368 no 2059 0.381343927740298 2964 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_63 0099-0242 26.702 µM -0.302947514041804 0.3877716538301 no 2060 0.380964930365185 3092 3898502 YLR359W ADE13
SGTC_2025 5147754 141 µM -0.305254423220422 0.386875804057017 no 2061 0.380086192656589 3027 315777 YLR208W SEC13
SGTC_2467 5474540 200 µM -0.305380787071995 0.386826750117336 no 2062 0.380038076524728 2936 5413519
SGTC_2349 9023730 187.07 µM -0.307256026975718 0.386099002404188 no 2063 0.379324251599399 3095 4126287
SGTC_1604 st002052 72.4 µM -0.307263931316059 0.386095935714408 no 2064 0.379321243618252 3076 6254834 YHR062C RPP1
SGTC_1391 3442-0225 151 µM -0.308127664071112 0.385760871552407 no 2065 0.378992595872238 2942 5227075
SGTC_1878 temozolomide 1 mM -0.310464800957262 0.384854663935169 no 2066 0.378103761342399 3051 5394 DNA alkylating agent.
SGTC_148 3253-0744 288.01 µM -0.311643282495604 0.384397954494036 no 2067 0.377655818265899 2932 6893655
SGTC_604 1000-0114 314 µM -0.311710274982152 0.384371996998858 no 2068 0.377630359229839 3096 1572745
SGTC_480 am 92016 50 µM -0.312759520889761 0.383965514721691 no 2069 0.377231685600114 3022 2129 K+ channel blocker.
SGTC_2887 9044784 58.44 µM -0.314507249317861 0.383288720897943 no 2070 0.376567905722723 2971 6465546
SGTC_1229 0139-0193 12.2 µM -0.315954019140419 0.382728740123381 no 2071 0.376018704525589 3127 3090752
SGTC_3289 9119912 71.43 µM -0.316268617900514 0.382607005220426 no 2072 0.375899314420014 3060 17014829
SGTC_3169 9102970 49.47 µM -0.318172758922464 0.381870440279214 no 2073 0.375176947559352 2986 17027839
SGTC_1479 0549-0158 134 µM -0.318614533822655 0.38169961271692 no 2074 0.375009415508852 3008 5440202
SGTC_1520 flindersine 88 µM -0.319126270137484 0.381501760950972 no 2075 0.374815381824894 3238 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_985 1493-0307 8.71 µM -0.320126699230175 0.381115056171949 no 2076 0.374436143374433 3115 3278274
SGTC_2722 naftopidil 47.16 µM -0.320138728719928 0.381110407027405 no 2077 0.374431584024275 3082 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3087 9117406 49.47 µM -0.321564138721165 0.38055963773322 no 2078 0.373891457540644 3082 42546093
SGTC_2266 7929956 200 µM -0.321874019760963 0.380439933670816 no 2079 0.373774067935474 2920 2967153
SGTC_1131 3454-3128 32.3 µM -0.324514176543343 0.3794205318636 no 2080 0.372774395584968 3119 710982
SGTC_75 0159-0059 199.013 µM -0.324833563923964 0.379297268547281 no 2081 0.372653520261799 3268 5377270
SGTC_2047 4141938 200 µM -0.325604497878112 0.378999787403794 no 2082 0.372361804344446 3007 3807862
SGTC_3108 9121785 49.47 µM -0.325923161557887 0.378876845214775 no 2083 0.372241245655701 2901 17140271
SGTC_2355 9061122 103.12 µM -0.326028450157493 0.378836226990317 no 2084 0.372201415014289 3094 5302957
SGTC_2922 7999257 32.47 µM -0.326457972134626 0.378670539917434 no 2085 0.372038941166402 2981 2988377
SGTC_1812 st052057 4.327 µM -0.326935137056161 0.378486500839057 no 2086 0.371858472292795 2955 3645418
SGTC_274 sirtinol 40.1 µM -0.329163557118413 0.377627380744892 no 2087 0.371016033326377 3014 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3075 9116269 49.47 µM -0.329286825139661 0.377579874995944 no 2088 0.370969450689511 3195 17015205 YNL244C SUI1
SGTC_358 0075-0058 9.45 µM -0.330550262900113 0.377093070866512 no 2089 0.370492110247769 3103 1069125
SGTC_598 3937-0236 20.2 µM -0.330710980939425 0.377031159992068 no 2090 0.370431403510622 3054 1379313
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.331245880018586 0.376825132036638 no 2091 0.370229383614647 3229 6728940
SGTC_2956 9076196 2.52 µM -0.332282301607847 0.376426031692842 no 2092 0.369838051342314 3120 16423868
SGTC_2309 7664088 163.95 µM -0.333857237971682 0.375819815568993 no 2093 0.369243644630156 3175 704922
SGTC_1683 st010134 710 nM -0.334187786454515 0.375692621455358 no 2094 0.369118929860478 2976 3818134
SGTC_3141 9094609 49.47 µM -0.334707219691887 0.375492772322482 no 2095 0.368922977380705 2941 25236309 YDL196W YDL196W
SGTC_1609 st001574 46.4 µM -0.334985665326077 0.375385655618461 no 2096 0.368817949775236 2982 3960012
SGTC_1233 0325-0408 14.2 µM -0.335327308780537 0.375254240140983 no 2097 0.368689097809948 3112 12874
SGTC_889 0919-1524 82.7 µM -0.335604264425792 0.375147717893173 no 2098 0.36858465389953 3051 3905452
SGTC_594 1487-1584 10.8 µM -0.335888220155092 0.375038513169286 no 2099 0.368477580236463 3006 5013332
SGTC_1045 1348-1485 165 µM -0.33731498146561 0.374489955905868 no 2100 0.36793973362559 2990 6810614
SGTC_2634 4'-methoxyflavone 100 µM -0.338404294955711 0.374071310535797 no 2101 0.367529268977254 3054 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.338610938104032 0.37399191010335 no 2102 0.367451420748464 3064 77254
SGTC_251 melphalan 456.522 µM -0.340844447502274 0.373134049684321 no 2103 0.366610343777494 3068 460612 A DNA alkylator.
SGTC_1119 parthenolide 318.541 nM -0.341944642913517 0.372711710467888 no 2104 0.366196276115978 3199 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_872 0588-0139 234 µM -0.342245327857812 0.372596311165787 no 2105 0.36608313792576 3007 2047100
SGTC_2876 9059903 25.97 µM -0.342411365961843 0.372532592618221 no 2106 0.366020668051943 2990 6916095
SGTC_476 mead acid 10 µM -0.342580464207514 0.372467703300618 no 2107 0.365957050486326 2988 5312531 An omega 9 fatty acid.
SGTC_1291 0993-0025 5.79 µM -0.342828725604654 0.372372442682005 no 2108 0.365863657107085 3126 4353356
SGTC_2603 homopterocarpin 100 µM -0.3433734565735 0.372163450809852 no 2109 0.365658762791152 3112 101795 A weak amylase inhibitor.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.345547672927516 0.371329665006984 no 2110 0.364841338462243 3018 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_899 1083-0020 478 µM -0.34586702803573 0.371207246904238 no 2111 0.364721324468261 3181 767123
SGTC_2459 5811157 9.22 µM -0.347430852527333 0.370607975821453 no 2112 0.364133829118664 3015 2870684 YBR192W RIM2
SGTC_1741 st038134 10.228 µM -0.348681935505043 0.37012877585767 no 2113 0.363664053760006 3245 1272587
SGTC_140 0062-0056 502.533 µM -0.350478373550227 0.369441042161801 no 2114 0.362989858800777 2979 3758964
SGTC_2557 derrustone 83.84 µM -0.351208394470654 0.369161686096799 no 2115 0.362716006448973 3147 629853 An antioxidant.
SGTC_1159 4092-0538 61.2 µM -0.351444589302497 0.369071316542411 no 2116 0.362627417835264 3043 717301
SGTC_1611 st001856 99.4 µM -0.352360054059303 0.368721122674824 no 2117 0.362284127797345 3069 647478
SGTC_1515 3460-0031 42.1 µM -0.353271451594671 0.368372592898076 no 2118 0.361942472907566 3059 2876596
SGTC_2835 9006588 71.43 µM -0.353639225551041 0.368231982199999 no 2119 0.36180463690047 3230 2345538
SGTC_1295 1013-0063 9.78 µM -0.354277790992854 0.36798788196179 no 2120 0.361565355012999 3160 6826038
SGTC_3192 9110362 49.47 µM -0.354794067744796 0.367790567180921 no 2121 0.361371936450711 3032 16649480
SGTC_2606 farnesol 9.78 µM -0.356695668885672 0.367064099293213 no 2122 0.360659824135163 3197 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2420 aureobasidin a 50 nM -0.358568669439089 0.366349022656302 no 2123 0.359958894185404 3289 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3101 9120531 49.47 µM -0.358668916403255 0.366310763291683 no 2124 0.359921392175454 3241 24824904
SGTC_1343 1487-0095 224 µM -0.359781002162963 0.365886423747558 no 2125 0.35950545562316 3180 4560101 YGL055W OLE1
SGTC_213 1246-0773 967 nM -0.359877753918273 0.365849513843114 no 2126 0.359469276894129 3083 6251622
SGTC_3072 9116419 49.47 µM -0.362357870136693 0.36490379707064 no 2127 0.358542309021904 3086 17170162
SGTC_2997 9067075 71.4286 µM -0.362915506070476 0.364691272481143 no 2128 0.358334001580353 3127 27209819
SGTC_1921 5740136 50 µM -0.363488173276762 0.364473062487212 no 2129 0.358120123010596 3212 1774243
SGTC_613 3914-0030 117 µM -0.363627553065946 0.364419959639433 no 2130 0.358068074467217 2958 1145395
SGTC_2014 4013930 200 µM -0.363727199915233 0.364381996393981 no 2131 0.358030864998 3127 64556
SGTC_2173 5763948 167 µM -0.364944044531018 0.363918512926659 no 2132 0.357576587792169 3060 2867177
SGTC_2971 9092186 9.93 µM -0.365201352377543 0.363820532510092 no 2133 0.357480554431192 3005 25236400
SGTC_662 k832-1615 104 µM -0.365291351389057 0.363786263831444 no 2134 0.357446966805881 3128 5878478
SGTC_2345 9052315 157.45 µM -0.366717603610299 0.363243339268973 no 2135 0.356914837128991 3134 6469265
SGTC_1371 2421-0008 32.7 µM -0.368790849717962 0.362454616682088 no 2136 0.356141812776295 3068 2827552
SGTC_658 3253-0951 102 µM -0.369780829728402 0.36207820534167 no 2137 0.355772900025907 3100 1184878
SGTC_651 3253-0966 34.4 µM -0.36984717005859 0.362052986108343 no 2138 0.355748183346878 3073 781462
SGTC_2159 5658611 73.75 µM -0.370025190929816 0.36198531455013 no 2139 0.355681860404625 3171 793844
SGTC_1404 3909-7820 48.3 µM -0.372700326285039 0.360968928700828 no 2140 0.354685746793345 3162 23741373
SGTC_2773 thioridazine 9.09 µM -0.374135314709751 0.360424125674567 no 2141 0.354151823053018 3100 5452 An antipsychotic.
SGTC_729 4092-0585 94.1 µM -0.374617315461936 0.3602411943345 no 2142 0.353972546729846 3045 2169061
SGTC_474 dl-dihydrosphingosine 5 µM -0.374670411086105 0.360221045172746 no 2143 0.353952800215795 3209 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1261 0712-0010 12.7 µM -0.37565127343306 0.359848889397747 no 2144 0.353588083571833 3242 2840123
SGTC_257 daunorubicin 18.5 µM -0.375854483863001 0.359771804520274 no 2145 0.353512540091024 3156 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1250 0485-0349 40.2 µM -0.376950214114507 0.359356253790193 no 2146 0.353105301848756 3079 6842794 YDL195W SEC31
SGTC_3065 9113888 49.47 µM -0.378243921019052 0.358865835413046 no 2147 0.352624700283466 3252 16648368
SGTC_2320 7373003 200 µM -0.37932438139904 0.358456432692771 no 2148 0.352223498213471 3137 5415828
SGTC_2867 9039098 71.43 µM -0.37941983683073 0.358420271003226 no 2149 0.352188061112457 3032 6463460
SGTC_2049 5262831 67.185 µM -0.380619274610924 0.357965992415409 no 2150 0.351742888458372 3142 763417
SGTC_1751 st044839 27.194 µM -0.381343157542986 0.357691924108485 no 2151 0.351474316793156 3131 5291326
SGTC_2321 7390090 138.78 µM -0.384844641853625 0.356367269879214 no 2152 0.350176261092194 3116 649046
SGTC_831 k061-1017 217 µM -0.384978644151294 0.356316609468656 no 2153 0.350126618959319 3154 1240153
SGTC_3023 9089636 49.47 µM -0.385168421123529 0.356244867430543 no 2154 0.350056319071357 3191 17249241
SGTC_2094 5332512 191.667 µM -0.385222660180131 0.3562243641892 no 2155 0.350036228011862 3221 755774
SGTC_716 1683-5115 658 µM -0.385508964676737 0.356116143344395 no 2156 0.349930182964697 3116 723597
SGTC_840 0245-0196 390 µM -0.38589709612586 0.355969451220656 no 2157 0.34978644066423 3220 3827528
SGTC_573 3702-0553 84.7 µM -0.386342672639814 0.35580107434096 no 2158 0.349621450451087 3092 1222756
SGTC_298 1391-0729 10 µM -0.388221008663968 0.355091588042111 no 2159 0.3489262436894 3072 3237558
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.388535777560489 0.35497274238618 no 2160 0.348809791443458 3064 16486 A toxic proline analog.
SGTC_1688 st021091 57.6 µM -0.389565622439001 0.354584007860286 no 2161 0.348428888472914 3207 3656366
SGTC_1062 mesoridazine 14.2 µM -0.392362406709757 0.353529073385656 no 2162 0.347395229360929 3097 4078 A neuroleptic.
SGTC_2235 salicylic acid 500 µM -0.392977183646266 0.353297332704306 no 2163 0.347168166666423 3155 338 A COX inhibitor and kinase inhibitor.
SGTC_2137 5261020 140 µM -0.393407286028095 0.353135237577837 no 2164 0.347009344572261 3081 763655
SGTC_2423 st077119 87.2 µM -0.393912425796677 0.352944896708853 no 2165 0.346822848052673 3148 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_999 SEC7.066 22.7 µM -0.395413400558819 0.352379534188565 no 2166 0.346268910479005 3082 740511 YDR170C SEC7
SGTC_715 0868-0130 184 µM -0.395638491459297 0.352294778726277 no 2167 0.346185868570612 3251 2876258
SGTC_673 1082-0474 110 µM -0.395687762333521 0.352276227307752 no 2168 0.346167692245456 3129 3098046
SGTC_1139 k015-0024 46.9 µM -0.396755549923249 0.351874271446318 no 2169 0.345773866027795 3221 2766652
SGTC_3247 9135149 49.47 µM -0.396765884982451 0.3518703817449 no 2170 0.345770055019286 3115 8934436 YOR116C RPO31
SGTC_3112 9123419 49.47 µM -0.397169058578273 0.351718655489859 no 2171 0.345621398693665 3092 17015854
SGTC_1486 3970-0793 4.53 µM -0.397806545096827 0.351478798487098 no 2172 0.345386396157642 3190 2844330
SGTC_3198 9112019 49.47 µM -0.398562941099053 0.351194277989772 no 2173 0.345107636225421 3113 45595555
SGTC_1101 ebselen 5.29 µM -0.39883078143304 0.351093549072738 no 2174 0.345008947283296 3249 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_880 0833-0487 87.2 µM -0.400503678567801 0.350464645863133 no 2175 0.344392787304876 3100 76075
SGTC_1665 st014639 11.4 µM -0.401533021067328 0.350077881853138 no 2176 0.34401386579006 3167 981133 YIL048W NEO1
SGTC_2083 5306046 65.942 µM -0.404031618422768 0.349139709005592 no 2177 0.343094734250107 3146 539837
SGTC_3113 9123498 49.47 µM -0.404123462917105 0.349105240772289 no 2178 0.343060966067876 3189 8897275
SGTC_1285 0929-0069 65.5 µM -0.405741625753415 0.348498166368826 no 2179 0.342466226906078 3150 1206237
SGTC_2070 5230947 200 µM -0.405781780445107 0.348483106749771 no 2180 0.342451473418887 3233 2835538
SGTC_3196 9111891 49.47 µM -0.406414825327822 0.348245721115587 no 2181 0.342218914208383 3146 18891510
SGTC_3140 9094243 49.47 µM -0.406657787376405 0.348154628504854 no 2182 0.342129674077783 3207 19291112
SGTC_881 0833-0569 170 µM -0.407143659562935 0.347972489025841 no 2183 0.341951239333196 3138 5418700
SGTC_1059 3448-6867 171 µM -0.407148524412633 0.347970665511169 no 2184 0.341949452913731 3201 3934407
SGTC_3138 9097216 49.47 µM -0.407760006324828 0.3477414888544 no 2185 0.341724939076759 3179 25237486
SGTC_349 k015-0014 24 µM -0.407875181894758 0.347698328547513 no 2186 0.341682657073929 3054 2196908
SGTC_2512 diallyl trisulfide 49.23 µM -0.409639985325564 0.347037242223832 no 2187 0.34103503029619 3182 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.410743020533808 0.346624287024604 no 2188 0.340630488997554 3280 1273210
SGTC_2836 9010338 19.48 µM -0.410809602599988 0.346599365803386 no 2189 0.340606075695686 3116 2994051
SGTC_1263 0774-1208 64.8 µM -0.411672388801928 0.346276490782166 no 2190 0.340289782763445 3301 906585
SGTC_606 k015-0008 38.6 µM -0.412401680372513 0.346003659703026 no 2191 0.340022515859013 3259 1970475
SGTC_2643 anethole 100 µM -0.412597076791137 0.345930574641508 no 2192 0.339950921663114 3178 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2803 7707263 71.43 µM -0.413399103322078 0.345630648958969 no 2193 0.339657115740657 3097 2199229
SGTC_3269 9137823 49.47 µM -0.413587073359997 0.345560369726319 no 2194 0.3395882708663 3101 17682936
SGTC_1187 1391-0724 117 µM -0.415787426348242 0.344738086522828 no 2195 0.338782780197786 3194 6997986
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.416909540374295 0.344319028690131 no 2196 0.338372287515642 3299 551469
SGTC_2470 5664817 21.68 µM -0.417328877023732 0.344162474804852 no 2197 0.338218934692497 3193 2859561
SGTC_704 1310-0270 142 µM -0.418043931674631 0.343895580052529 no 2198 0.33795749870663 3177 5718033
SGTC_1274 0865-0114 173 µM -0.419349733417849 0.343408389202894 no 2199 0.337480277378692 3177 870624
SGTC_1720 st037298 9.481 µM -0.419857328686208 0.343219077029029 no 2200 0.337294840914827 3228 597396
SGTC_1731 st035964 63 µM -0.420681263502138 0.342911866971629 no 2201 0.336993922336944 3133 6739575
SGTC_1353 1498-1206 8.11 µM -0.421171122398017 0.342729268739745 no 2202 0.336815064834933 3217 6756808
SGTC_2122 5258151 111.688 µM -0.421919295427478 0.342450453074817 no 2203 0.33654196278351 3154 2173356
SGTC_2078 5212016 200 µM -0.422263191435661 0.342322324881973 no 2204 0.336416460963099 3190 1899708
SGTC_586 0957-0265 8.15 µM -0.424903724370636 0.341339125158821 no 2205 0.335453429772202 3223 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1762 st045503 25.4615 µM -0.425333849146152 0.341179070374265 no 2206 0.335296660705265 3218 4645554
SGTC_1190 1486-1332 13 µM -0.425357751147629 0.341170176979588 no 2207 0.335287949900856 3201 4150046
SGTC_2987 9018338 71.43 µM -0.427422960587721 0.34040209282259 no 2208 0.334535643358027 3288 5055682
SGTC_182 3448-4371 550.524 µM -0.428226911915806 0.340103269283102 no 2209 0.334242962414169 3260 3491403
SGTC_1281 0884-0031 11.8 µM -0.428275128123485 0.340085350818489 no 2210 0.334225412356742 3174 1548255
SGTC_679 0422-0091 41.4 µM -0.429770868458348 0.339529672271313 no 2211 0.333681162958353 3148 627384 YHR062C RPP1
SGTC_1816 st051957 91.6 µM -0.433201167538441 0.338256609247379 no 2212 0.332434315379867 3197 674121
SGTC_2849 9019321 12.99 µM -0.43373079838327 0.338060215268784 no 2213 0.332241969478111 3254 16489627
SGTC_2966 9084041 48.03 µM -0.433867421012871 0.338009560975192 no 2214 0.332192359438288 3043 17741380
SGTC_1432 4049-0298 68.4 µM -0.433881959226741 0.33800417095035 no 2215 0.332187080534472 3258 741646
SGTC_1740 st038286 13.222 µM -0.434363495359517 0.337825660797056 no 2216 0.332012250991634 3356 716786
SGTC_1838 st055369 84.5 µM -0.434535002830578 0.337762090106525 no 2217 0.331949991237283 3206 676036
SGTC_89 0302-0250 142.109 µM -0.434604426815965 0.337736358836613 no 2218 0.331924790620577 3250 4203518 YLR208W SEC13
SGTC_1178 0988-0033 191 µM -0.434952948533826 0.337607194390759 no 2219 0.331798290184497 3270 5392207
SGTC_2945 9067681 61.76 µM -0.435983507229375 0.337225374494566 no 2220 0.331424347887571 3261 16456930
SGTC_250 brefeldin a 552.239 µM -0.43822016823424 0.336397273154074 no 2221 0.330613344930884 3173 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1466 k213-0079 57.5 µM -0.438482465728082 0.336300212009328 no 2222 0.330518289057632 3192 3657981
SGTC_2565 isoliquiritigenin 100 µM -0.439425386407325 0.335951381699655 no 2223 0.330176667582569 3259 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_625 k213-0058 121 µM -0.440500733630155 0.335553733053018 no 2224 0.329787240528336 3248 3655420
SGTC_1625 st003711 30.1 µM -0.441507337482728 0.335181671575564 no 2225 0.3294228753599 3375 24207034 YER133W GLC7
SGTC_1227 3909-8010 46.6 µM -0.441696458043422 0.335111786755149 no 2226 0.329354436550918 3174 15982272
SGTC_2646 retinol 96.75 µM -0.442423679427995 0.334843113287152 no 2227 0.329091323485576 3271 445354 A vitamin A analog and teratogen.
SGTC_1235 benzylparaben 21.5 µM -0.443016622400941 0.334624111800106 no 2228 0.328876855791568 3257 7180
SGTC_2705 st078069 42.8 µM -0.443595832375532 0.334410236858414 no 2229 0.328667409715619 3245 1530061
SGTC_2732 terfenadine 20 µM -0.44424218009379 0.334171634552121 no 2230 0.328433749723561 3224 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1930 st074634 34.3 µM -0.444260581715103 0.334164842487333 no 2231 0.328427098368533 3148 684253 YOR116C RPO31
SGTC_2036 5160441 105 µM -0.445213236975656 0.333813290289399 no 2232 0.328082830833194 3221 134534 YIL048W NEO1
SGTC_2482 5981709 142.65 µM -0.445476114232092 0.333716308056931 no 2233 0.327987858773285 3208 877755
SGTC_2189 6047310 154.431 µM -0.446310756514693 0.333408460541621 no 2234 0.327686393691443 3172 711535
SGTC_292 k038-0015 474 µM -0.446343882878172 0.333396244603845 no 2235 0.327674431070419 3293 46368540
SGTC_1964 st076914 61 µM -0.446874936817485 0.333200433114254 no 2236 0.327482680565853 3243 24208661
SGTC_2352 9027995 87.8 µM -0.447642787916478 0.332917389595058 no 2237 0.327205508903205 3231 2997347
SGTC_1072 oxiconazole 14.9 nM -0.447925230527712 0.332813300179213 no 2238 0.327103579383766 3281 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1043 0916-0009 19.3 µM -0.447971488032895 0.332796253990847 no 2239 0.327086886937037 3353 3101130
SGTC_2329 6138490 200 µM -0.448026053667127 0.332776146647756 no 2240 0.327067196870098 3331 720019
SGTC_119 0121-0043 24.815 µM -0.448241568908845 0.332696734350699 no 2241 0.32698943267227 3294 1092378
SGTC_406 estrone 100 µM -0.448316647276111 0.332669071501119 no 2242 0.326962343967248 3342 5870 A steroid.
SGTC_1624 st003710 6.25 µM -0.448792020523478 0.332493939954141 no 2243 0.326790847744179 3288 24207033
SGTC_976 1348-1067 47.6 µM -0.449912908907061 0.332081139924366 no 2244 0.326386619590356 3206 5310671 YGL099W LSG1
SGTC_2011 4012611 177 µM -0.450047850892063 0.332031457307646 no 2245 0.326337968936896 3164 2049887
SGTC_977 1348-1378 135 µM -0.450651298535855 0.331809317537864 no 2246 0.326120444028035 3162 X977
SGTC_1889 st059080 5.18 µM -0.451677271566423 0.331431774421037 no 2247 0.325750747096807 3340 176925 Isolated from Daphnopsis sellowiana.
SGTC_1459 k035-0031 35.7 µM -0.454050148881252 0.330559246642691 no 2248 0.324896366237949 3150 3877128 YMR208W ERG12
SGTC_2141 5621638 7.665 µM -0.454519488496989 0.330386775198844 no 2249 0.324727484153706 3300 2856238
SGTC_895 0964-0006 13.7 µM -0.455049430514376 0.330192077075786 no 2250 0.324536838859212 3323 6738897
SGTC_2192 5915882 198.485 µM -0.455157943000302 0.330152215784265 no 2251 0.324497807436683 3237 2876149
SGTC_1116 jasmonic acid 1.58368 µM -0.455974527412472 0.329852311162857 no 2252 0.324204147788512 3313 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2541 muurolladie-3-one 83.07 µM -0.456129532075505 0.329795395385626 no 2253 0.324148417435291 3365 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1564 D-Arginine 115 µM -0.456195887669141 0.32977103164453 no 2254 0.324124561159468 3238 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.456198973957759 0.329769898471479 no 2255 0.324123451589313 3209 2333 A French combination drug.
SGTC_1662 st014054 52 µM -0.458217904320196 0.329028955839556 no 2256 0.323397948971465 3232 2838777
SGTC_924 2046-0044 21.3 µM -0.458658237117826 0.32886744381624 no 2257 0.323239804415276 3255 3623589
SGTC_488 nitrendipine 139 µM -0.459389220957515 0.328599392900342 no 2258 0.322977343701326 3270 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1402 3909-7673 35.9 µM -0.459579859007386 0.32852950064205 no 2259 0.322908909340639 3243 5328014
SGTC_1885 st057546 99.9 µM -0.461295496324378 0.327900779033619 no 2260 0.322293307835706 3373 702008
SGTC_3130 9127414 49.47 µM -0.461323898804379 0.327890374606094 no 2261 0.32228312060939 3295 1494646
SGTC_1385 3091-4834 14.1 µM -0.461539607086464 0.32781136047265 no 2262 0.322205756050293 3296 4072814
SGTC_2645 abamectin 100 µM -0.46201607984106 0.327636855405284 no 2263 0.322034894665202 3284 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_656 4090-1979 187 µM -0.463151393619941 0.327221205829336 no 2264 0.321627926926297 3341 22330961
SGTC_626 0214-0009 33 µM -0.463203375817026 0.327202179757787 no 2265 0.321609298361992 3336 3437874
SGTC_3227 9130768 49.47 µM -0.463419027549511 0.327123253582228 no 2266 0.321532021267865 3269 17720899
SGTC_1569 carminic acid 40.6 µM -0.464434449110227 0.326751724341326 no 2267 0.321168256811669 3355 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3149 9097855 49.47 µM -0.464551814675444 0.326708792906391 no 2268 0.321126222842366 3326 25236625 YMR079W SEC14
SGTC_218 alverine citrate 93.75 µM -0.46488785509785 0.326585884555519 no 2269 0.321005884095297 3329 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1971 st069429 63.5 µM -0.464907969421001 0.326578528244935 no 2270 0.320998681592414 3302 1246522 YGL099W LSG1
SGTC_278 4092-0821 23.9 µM -0.464933309906351 0.326569260692235 no 2271 0.320989607810068 3294 877900
SGTC_1425 4048-4433 7.33 µM -0.464956122266754 0.32656091781997 no 2272 0.320981439376308 3318 23734946
SGTC_1457 k015-0032 57.3 µM -0.467437792532075 0.325653847117582 no 2273 0.320093344508009 3292 4302660
SGTC_2237 6667747 47.222 µM -0.467893423711876 0.325487422111129 no 2274 0.319930403280958 3154 729940 YDL015C TSC13
SGTC_1646 st011709 75.6 µM -0.468383463037926 0.325308467924458 no 2275 0.319755195900586 3326 5757843
SGTC_234 nsc-17383 10.7 µM -0.468704064175213 0.325191411528925 no 2276 0.319640590764384 3363 408974
SGTC_2699 st077704 54.6 µM -0.469305471032509 0.324971875187955 no 2277 0.319425652597316 3287 645852
SGTC_2062 5245942 200 µM -0.47015350229435 0.324662414830994 no 2278 0.319122675853763 3323 1376160
SGTC_3094 9117742 49.47 µM -0.470265389210117 0.324621594512078 no 2279 0.319082710949102 3227 17149698
SGTC_114 0364-0001 490.298 µM -0.470458533092954 0.324551133724023 no 2280 0.319013726804044 3304 4003655
SGTC_1382 3002-2117 298 µM -0.471362705237871 0.324221366373286 no 2281 0.318690871966537 3378 1497314
SGTC_111 0083-0039 52.457 µM -0.473003621151586 0.323623247930547 no 2282 0.31810529785179 3217 759313
SGTC_385 1494-0393 12.4 µM -0.473538869144546 0.323428246949994 no 2283 0.317914388484327 3252 3090647
SGTC_1393 3470-5649 58.2 µM -0.474859946374351 0.322947161114083 no 2284 0.317443400945313 3269 4108395
SGTC_823 0417-1665 178 µM -0.476236873484817 0.322446051989193 no 2285 0.316952816304533 3284 3429856
SGTC_206 4546-0025 72.014 µM -0.476437573905781 0.322373037397684 no 2286 0.316881335693152 3330 6620745 YIL048W NEO1
SGTC_1868 st057644 42.7 µM -0.47648307640699 0.322356484590713 no 2287 0.316865130665514 3211 688665
SGTC_3349 9149703 23.001 µM -0.476552075180832 0.322331385029658 no 2288 0.316840558466054 3291 4910494
SGTC_3134 9127454 49.47 µM -0.477906599168299 0.321838816398901 no 2289 0.316358342122711 3376 24262820
SGTC_3318 9139014 38.6185 µM -0.478259012679888 0.32171071353278 no 2290 0.316232932531138 3258 16643984
SGTC_1366 1683-0113 21.9 µM -0.478611097720576 0.321582751228909 no 2291 0.316107660934785 3237 708623
SGTC_52 0329-0193 875 nM -0.479536863358408 0.321246390631631 no 2292 0.315778374955355 3426 3739292
SGTC_2109 5483026 200 µM -0.479636534231655 0.321210185714889 no 2293 0.315742931690109 3265 759335
SGTC_1436 4092-1007 8.32 µM -0.480634022782146 0.320847946924161 no 2294 0.315388315105464 3241 2881121
SGTC_3132 9126706 49.47 µM -0.480887816754636 0.32075580862678 no 2295 0.315298116069461 3399 850858
SGTC_1037 k284-1091 78.7 µM -0.48277695818867 0.320070315046521 no 2296 0.31462705653035 3322 3334711
SGTC_245 methotrexate 289.6 µM -0.483222189825341 0.319908847649084 no 2297 0.314468990660363 3306 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_682 0kpi-0099 17 µM -0.484151273549617 0.31957201668359 no 2298 0.314139257451399 3335 1714895 YML126C ERG13
SGTC_2131 toluylene red 5.2905 µM -0.487926471072878 0.31820488565511 no 2299 0.312800961902446 3250 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2115 tiliquinol 12.7705 µM -0.488022977747777 0.318169969552179 no 2300 0.312766782815079 3295 71208 A bioactive hydroxyquinoline.
SGTC_1500 4488-1866 171 µM -0.490253012704432 0.317363593747109 no 2301 0.31197743594251 3406 2900003
SGTC_279 1273-0055 2.93 µM -0.492535165790391 0.316539268682255 no 2302 0.31117053425274 3335 2847562
SGTC_186 3455-3465 67.277 µM -0.49263669241758 0.316502617882301 no 2303 0.311134658483409 3296 755278
SGTC_2844 9010103 25.97 µM -0.492657015385573 0.316495281569834 no 2304 0.31112747731084 3384 2480525
SGTC_2614 arthonioic acid 13.39 µM -0.492831527902817 0.316432287918887 no 2305 0.311065815827536 3321 6710684
SGTC_948 3448-0295 75.3 µM -0.493121850197584 0.316327502300262 no 2306 0.310963246378235 3342 678569
SGTC_2980 9014342 25.29 µM -0.493517149808337 0.316184851075179 no 2307 0.310823612564051 3404 2996599
SGTC_2626 ethyl orsellinate 100 µM -0.495152700289959 0.315594923162205 no 2308 0.31024616791836 3246 75653 A natural product.
SGTC_513 4245-1575 41.7 µM -0.495308049760856 0.315538914444269 no 2309 0.310191344791177 3288 719745
SGTC_760 0568-0725 82.9 µM -0.495651867992048 0.315414971456405 no 2310 0.310070025676148 3384 3916171
SGTC_31 0508-1974 57.237 µM -0.496150289141252 0.315235332558756 no 2311 0.309894190348287 3354 6810525
SGTC_2383 9036125 200 µM -0.497721108121495 0.314669470347021 no 2312 0.309340314117927 3259 79580
SGTC_455 paf C-16 10 µM -0.498588032889178 0.31435736085356 no 2313 0.309034818738135 3293 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2978 9011784 42.97 µM -0.500230861910348 0.313766275016554 no 2314 0.30845626494365 3338 2994934
SGTC_786 4544-0069 423 µM -0.500923304817757 0.31351727877495 no 2315 0.308212550181445 3342 748821 YLR208W SEC13
SGTC_1091 telmisartan 47.6 µM -0.501353540601728 0.313362612637672 no 2316 0.308061165373085 3395 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1809 st050081 57.6 µM -0.502839970007706 0.31282850648356 no 2317 0.307538394653473 3440 5036894
SGTC_2684 capsaicin 100 µM -0.503973405088545 0.312421502601433 no 2318 0.307140032918073 3394 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2428 5615643 7.78 µM -0.505192570083419 0.311983969382221 no 2319 0.3067117941549 3357 2253075
SGTC_591 4299-0174 154 µM -0.505889962280682 0.311733808848426 no 2320 0.306466949631274 3296 5509088
SGTC_1195 1502-0147 41.1 µM -0.506853899508167 0.311388179333616 no 2321 0.306128667130473 3348 817940
SGTC_133 0724-0033 378.92 µM -0.50709576664744 0.311301481474248 no 2322 0.306043812608124 3211 280309
SGTC_3048 9093155 49.47 µM -0.508708559186411 0.310723639850689 no 2323 0.305478261010114 3378 25236002
SGTC_1067 clotrimazole 1.36 µM -0.5088259955792 0.310681582196026 no 2324 0.305437098156262 3312 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1617 st002906 78 µM -0.509086221487355 0.310588395953791 no 2325 0.305345894641465 3355 5150859
SGTC_1793 st048256 72.231 µM -0.510392080718138 0.310120954651904 no 2326 0.30488840194041 3337 672022
SGTC_337 1315-0038 354 µM -0.51126825021199 0.309807495601704 no 2327 0.304581616910951 3320 1626437
SGTC_1977 st070720 65.3 µM -0.511341669767635 0.309781235241025 no 2328 0.304555915769345 3395 682188
SGTC_3224 9130643 49.47 µM -0.512212582833822 0.309469805242139 no 2329 0.304251118857311 3446 17644395
SGTC_2823 7987624 58.44 µM -0.513757000259621 0.308917873110172 no 2330 0.303710947324253 3490 2239440
SGTC_2930 9013230 14.89 µM -0.515434881620963 0.308318733309146 no 2331 0.303124581380863 3395 2995857
SGTC_1641 st009299 47.1 µM -0.516386128004511 0.307979287676245 no 2332 0.302792376223471 3370 4046054
SGTC_927 2425-1185 123 µM -0.518426171242513 0.307251866495097 no 2333 0.302080479350429 3255 730375
SGTC_614 0462-0418 107 µM -0.519113503722516 0.307006953858293 no 2334 0.301840796039385 3299 5188303
SGTC_222 nsc-310342 10.666 µM -0.519556469400158 0.306849160439673 no 2335 0.301686372460854 3379 432556
SGTC_1965 Pectolinarigenin 58.4 µM -0.519653119170156 0.30681473657231 no 2336 0.30165268381975 3316 5320438 An anti-inflammatory.
SGTC_2186 6124449 200 µM -0.521323249421659 0.306220153499437 no 2337 0.301070803782837 3394 3834182 YLR033W RSC58
SGTC_1692 fluoroquinolonic acid 71 µM -0.521486056563717 0.306162219786679 no 2338 0.301014108195517 3402 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1146 3579-1023 7 µM -0.521674380337172 0.306095212216308 no 2339 0.300948532758878 3414 X1146
SGTC_1666 st014829 29 µM -0.52187324064769 0.306024462677697 no 2340 0.300879295431374 3358 3858230
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.523707384037314 0.305372261616611 no 2341 0.300241039503711 3420 5282362
SGTC_2649 anisomycin 9.56 µM -0.525275094564457 0.304815290296727 no 2342 0.299695984107683 3396 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_983 1491-0821 12.2 µM -0.525688310772508 0.304668559348132 no 2343 0.299552393404439 3399 46495113
SGTC_1217 1183-1422 255 µM -0.527614033681341 0.303985159754182 no 2344 0.298883625320123 3414 2849664
SGTC_2568 diosmetin 100 µM -0.530096956375699 0.303105031575672 no 2345 0.29802235461268 3470 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1444 4112-3581 28 µM -0.530391192956819 0.303000808339248 no 2346 0.297920365484996 3416 2877249
SGTC_3156 9099931 49.47 µM -0.534553179681534 0.301528288266991 no 2347 0.296479433417347 3308 18111053
SGTC_676 falcarinol 140 µM -0.534900973463964 0.301405383958798 no 2348 0.296359167572655 3487 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2809 7964133 12.99 µM -0.535347588933307 0.301247590856052 no 2349 0.296204762353547 3339 1253665
SGTC_1915 st067105 30.6 µM -0.536463782460335 0.30085339283467 no 2350 0.295819030087691 3435 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_352 k048-0007 5.11 µM -0.536702363538966 0.300769165064892 no 2351 0.29573661158385 3413 6811911
SGTC_3003 9075612 71.4286 µM -0.537024225014385 0.300655553157666 no 2352 0.295625440354689 3398 6501993
SGTC_3256 9138902 49.47 µM -0.5385769782078 0.300107728698082 no 2353 0.295089388157095 3383 17228773
SGTC_3073 9114972 49.47 µM -0.539591247117422 0.299750129999716 no 2354 0.294739477120161 3394 41905075
SGTC_1697 st025554 27.742 µM -0.540788581131617 0.299328236960948 no 2355 0.294326657161597 3393 1269519
SGTC_1163 k060-0048 49.9 µM -0.541813446957478 0.298967328960469 no 2356 0.293973513473214 3412 6809982
SGTC_3079 9117512 49.47 µM -0.543425809475674 0.298399933564417 no 2357 0.293418329720508 3439 7185044
SGTC_32 0928-0142 34.1 µM -0.545051452884738 0.297828361250414 no 2358 0.292859065232652 3420 2244242
SGTC_1152 3909-8331 15.9 µM -0.548764145954136 0.296524863334418 no 2359 0.291583659306088 3370 16001939
SGTC_467 ro 31-8220 72.8 µM -0.549103605310092 0.296405812311271 no 2360 0.291467175590136 3344 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1376 2910-0861 41.3 µM -0.549571781294435 0.296241655327384 no 2361 0.291306559052556 3419 1112859
SGTC_2458 5808907 16.39 µM -0.550463267610616 0.295929188000467 no 2362 0.291000832252442 3515 2731747
SGTC_1498 4478-3555 97.6 µM -0.550604483386563 0.295879705541588 no 2363 0.290952417394995 3441 3437919
SGTC_177 1327-0068 8.361 µM -0.552543134962071 0.295200780340578 no 2364 0.290288144885883 3436 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.552740875700012 0.295131570899235 no 2365 0.290220429620449 3364 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1058 3448-5425 97.3 µM -0.553233505018064 0.294959182684457 no 2366 0.290051763516507 3412 7279705
SGTC_1905 st060207 84.5 µM -0.55398861075115 0.294695034899212 no 2367 0.28979332013785 3380 1948547
SGTC_37 0566-0070 1.56 µM -0.554274677765351 0.294594992689808 no 2368 0.289695438729833 3397 1626686
SGTC_2287 7945887 168.79 µM -0.555045660780198 0.294325445652088 no 2369 0.289431714534804 3418 1245853
SGTC_757 1066-0008 322 µM -0.555568682411131 0.294142654436268 no 2370 0.289252872799569 3459 6842497
SGTC_2979 9012552 45.46 µM -0.557075382256972 0.293616370252425 no 2371 0.288737963223323 3498 17100905
SGTC_1826 st055655 41.6 µM -0.558271913061614 0.293198737682106 no 2372 0.288329360588945 3419 676168
SGTC_2917 7979103 53.79 µM -0.558815430893427 0.293009121291778 no 2373 0.288143845085177 3475 2980565
SGTC_447 ml7 120 µM -0.558933043969278 0.292968097253023 no 2374 0.288103708371108 3469 4216 Selective myosin light chain kinase inhibitor.
SGTC_2151 5563267 85.4165 µM -0.559113459705501 0.292905172507451 no 2375 0.288042144708654 3382 5310824
SGTC_1051 3253-3903 78 µM -0.559321228421208 0.292832715461178 no 2376 0.287971255021699 3367 5509239
SGTC_1082 camptothecin 424.86 nM -0.559728403646011 0.292690741733405 no 2377 0.287832352684968 3279 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2833 9001315 45.46 µM -0.561895205700271 0.291935760183765 no 2378 0.287093710183231 3321 2989378
SGTC_2644 guaiazulene 100 µM -0.562558203436345 0.291704932387056 no 2379 0.286867879936559 3454 3515 A coloring agent.
SGTC_3034 9090421 49.47 µM -0.56389534669587 0.291239654563856 no 2380 0.286412678546201 3425 17173761
SGTC_2942 9052777 62.25 µM -0.564442836568081 0.291049247770835 no 2381 0.286226396474483 3494 6469503
SGTC_516 3992-2719 87.3 µM -0.564821697153978 0.290917521158841 no 2382 0.286097523792644 3304 5350887 YDR037W KRS1
SGTC_1137 ixabepilone 100 µM -0.56623775324263 0.290425417327853 no 2383 0.285616084396301 3487 154225 A novel microtubule stabilizer.
SGTC_801 0866-0028 10.1 µM -0.567143530747738 0.290110848568182 no 2384 0.285308334940035 3467 6849771
SGTC_332 4112-0506 40.9 µM -0.568659953382856 0.289584565728247 no 2385 0.284793464900721 3444 2790355
SGTC_2737 bleomycin 30.5 nM -0.568767625626207 0.289547214531853 no 2386 0.284756923875491 3474 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2242 6630449 61.2675 µM -0.569064425591798 0.289444267177986 no 2387 0.284656209641763 3456 691249 YDR170C SEC7
SGTC_94 0334-0113 514.748 µM -0.571516301064607 0.288594473694434 no 2388 0.283824856837752 3425 6795178
SGTC_892 0929-0076 29 µM -0.572232360593319 0.288346517154012 no 2389 0.283582283368265 3419 5751038
SGTC_1695 st026914 34.495 µM -0.572451697419929 0.28827058546854 no 2390 0.283508000352494 3446 3289191
SGTC_814 3342-0569 96 µM -0.572870347262703 0.288125680275543 no 2391 0.283366241695682 3531 4346283
SGTC_231 b-estradiol 524 µM -0.57456851355279 0.287538255138497 no 2392 0.282791575875954 3385 450 A steroid.
SGTC_2798 7813637 45.45 µM -0.576054811363143 0.287024584111288 no 2393 0.282289067018441 3488 956368
SGTC_2641 levomentholum 100 µM -0.576353429932225 0.286921432682904 no 2394 0.282188157632998 3443 16666
SGTC_3201 9113999 49.47 µM -0.576405267351453 0.286903528339049 no 2395 0.282170642466593 3475 16649224
SGTC_2268 7933382 153.85 µM -0.578762226076671 0.286090008255552 no 2396 0.281374811180273 3514 935025 YOR257W CDC31
SGTC_926 2268-1401 59.4 µM -0.579345562028817 0.285888835267368 no 2397 0.281178014125506 3502 2931578
SGTC_1022 4477-0945 21.3 µM -0.580515343077208 0.28548561984047 no 2398 0.280783571522689 3463 4648966
SGTC_708 3448-5400 146 µM -0.580664304242088 0.285434293398496 no 2399 0.280733361993754 3485 3462195
SGTC_2895 9054447 58.44 µM -0.582201647762414 0.284904839208614 no 2400 0.280215431802157 3464 2697450
SGTC_991 3996-0057 64.7 µM -0.583218859505394 0.284554773793095 no 2401 0.279872988399485 3464 715343
SGTC_3332 9141069 11.198 µM -0.583287965134016 0.284530999088535 no 2402 0.279849731417699 3439 17332883
SGTC_2081 5214970 32.255 µM -0.583293922761022 0.284528949505093 no 2403 0.279847726466838 3471 2063512
SGTC_1001 4048-4355 44.4 µM -0.589205898779397 0.282498554841218 no 2404 0.277861580304477 3489 21824233
SGTC_1936 st074407 74.3 µM -0.589962961517518 0.282239055104829 no 2405 0.277607740677339 3435 809813
SGTC_169 k015-0017 16.025 µM -0.590616908015086 0.282014993090242 no 2406 0.277388566686796 3575 1840002
SGTC_179 1273-0063 6.77 µM -0.592472444968228 0.281379696347954 no 2407 0.276767133614884 3423 3108139
SGTC_1007 4101-0031 70 µM -0.592634115215106 0.281324376590987 no 2408 0.276713021368881 3517 1146276
SGTC_700 3453-2283 142 µM -0.593194037635357 0.281132824892351 no 2409 0.276525651205013 3558 565664
SGTC_264 promethazine 12.5 mM -0.594114764771739 0.280817977493125 no 2410 0.276217678119829 3576 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1747 st037496 66.6 µM -0.595233846198737 0.280435531507211 no 2411 0.275843584479392 3482 723305
SGTC_1785 bathophenanthroline 24 µM -0.597523597474499 0.279653795887107 no 2412 0.275078928514519 3432 72812 An iron chelator.
SGTC_2291 7917025 104.35 µM -0.598592256458729 0.279289311276138 no 2413 0.274722410542886 3454 2964612
SGTC_1645 Cervolide 78 µM -0.59916462644495 0.279094189575669 no 2414 0.274531554512624 3475 23173 A fragrance.
SGTC_2864 9034755 47.6 µM -0.599894553373514 0.278845452703573 no 2415 0.274288256271805 3521 4930451
SGTC_1833 st055984 71 µM -0.60014900480213 0.278758768768517 no 2416 0.274203467903691 3464 676288
SGTC_188 3229-0966 278.469 µM -0.600262324018737 0.278720168547714 no 2417 0.274165711812887 3559 5722370
SGTC_2100 5377183 190 µM -0.600692240477735 0.278573748647789 no 2418 0.274022494107617 3527 2844202
SGTC_1290 0986-0249 10.2 µM -0.600939240110198 0.278489643063166 no 2419 0.273940228055189 3482 53329
SGTC_1068 loratadine 26.9 µM -0.607042811214008 0.276415261596139 no 2420 0.271911250643556 3498 3957 A H1 histamine antagonist.
SGTC_2508 celastrol 40.54 µM -0.607321331455989 0.276320783801934 no 2421 0.271818842309521 3487 122724 Celastrol is a natural product and antioxidant.
SGTC_1014 4130-3005 69.3 µM -0.607930830675423 0.276114088791574 no 2422 0.271616675246936 3511 743608
SGTC_2690 usnic acid 100 µM -0.608674790139575 0.275861898171348 no 2423 0.271370010072637 3612 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_957 1187-1561 14.1 µM -0.611137127395438 0.275028012373826 no 2424 0.270554401172726 3518 1538454
SGTC_1326 1431-2094 10.8 µM -0.61146909918757 0.274915683126912 no 2425 0.270444534702914 3499 616278
SGTC_2150 5556613 200 µM -0.612329511383202 0.274624650853453 no 2426 0.270159884052811 3519 743190
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.612846636916114 0.274449807578429 no 2427 0.269988875248761 3593 1377
SGTC_1365 1672-3266 55.4 µM -0.613172690876352 0.27433959500517 no 2428 0.2698810799626 3547 6415873
SGTC_2342 7990637 118.86 µM -0.613950863416677 0.274076645902506 no 2429 0.269623898813306 3548 2033102 YER133W GLC7
SGTC_2395 5646831 180.19 µM -0.614176752908459 0.274000339834704 no 2430 0.269549266752046 3558 6808628
SGTC_2800 7887935 81.82 µM -0.614239360564203 0.273979192661402 no 2431 0.269528583521258 3526 2961002
SGTC_832 4083-0019 164 µM -0.614421787574349 0.273917578349948 no 2432 0.269468320987048 3608 1990758
SGTC_2511 berberine 10.47 µM -0.615591635371713 0.273522627770602 no 2433 0.269082036645132 3531 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_535 2293-4129 48.2 µM -0.616115054493072 0.273346008330618 no 2434 0.268909293408467 3562 396118 YIL048W NEO1
SGTC_796 1234-0020 70.7 µM -0.617025250007125 0.27303901192567 no 2435 0.268609035591309 3523 46495034
SGTC_208 k072-0098 12.366 µM -0.617553422104105 0.272860945154381 no 2436 0.268434878003004 3545 5948901
SGTC_848 0368-0089 85.6 µM -0.61778305779868 0.2727835442537 no 2437 0.268359176459147 3534 762535
SGTC_3032 9089427 49.47 µM -0.618222553141644 0.272635438536312 no 2438 0.268214322674938 3526 17173707
SGTC_1367 1812-0510 76.9 µM -0.618577093477967 0.272515990933616 no 2439 0.268097497987159 3502 1142582 YDR527W RBA50
SGTC_2788 5282734 71.43 µM -0.618709652815972 0.272471337259436 no 2440 0.268053824901046 3569 743706
SGTC_3135 9127742 49.47 µM -0.618926173471526 0.272398408358521 no 2441 0.267982497567733 3496 3643468
SGTC_1117 retinoic acid 1.10837 µM -0.619300549316989 0.272272333250449 no 2442 0.267859191328213 3582 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1572 epiandrosterone 68.9 µM -0.619855549255593 0.272085484397673 no 2443 0.267676446466376 3528 441302 A steroid.
SGTC_1774 st048371 48.465 µM -0.619966815742383 0.272048032579483 no 2444 0.267639817306713 3495 4242727
SGTC_1297 1068-0111 14.1 µM -0.620359973848366 0.271915717796255 no 2445 0.267510409076752 3508 767057
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.620458280426154 0.271882638365657 no 2446 0.267478056338421 3480 6708514
SGTC_158 k038-0087 26.446 µM -0.620587385740149 0.271839198431284 no 2447 0.267435570719853 3504 X158
SGTC_502 l-744,832 89.3 µM -0.621860131127301 0.271411143998678 no 2448 0.267016921445735 3529 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_652 0437-0092 114 µM -0.622117886593998 0.271324495637975 no 2449 0.266932177218095 3551 3091274
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.623134236486151 0.270982968808309 no 2450 0.266598156578895 3574 65057 A dermal irritant. YDR527W RBA50
SGTC_1540 guanosine 70.6 µM -0.623211218585522 0.270957109043545 no 2451 0.266572865233408 3517 6802 Guanosine is a purine nucleoside
SGTC_1027 k015-0025 8.67 µM -0.624119529674079 0.270652082915874 no 2452 0.266274544520738 3547 3598955
SGTC_1147 3809-1045 12.3 µM -0.624211540773813 0.27062119361054 no 2453 0.26624433432792 3506 325925
SGTC_2344 7990960 76.95 µM -0.624568456221191 0.270501389185475 no 2454 0.266127163968393 3514 140813
SGTC_172 1112-0046 2.638 µM -0.625128071157897 0.270313598771632 no 2455 0.265943502775604 3465 2802135 YIL048W NEO1
SGTC_178 4092-0806 87.505 µM -0.625128760598841 0.270313367455609 no 2456 0.265943276546156 3558 2169044
SGTC_2099 5377090 177.372 µM -0.625804313550583 0.270086758592291 no 2457 0.265721651094127 3531 2243829
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.628766051227796 0.269094390298768 no 2458 0.264751114291421 3554 688788
SGTC_1452 4194-0072 190 µM -0.628934266445027 0.269038082586812 no 2459 0.264696045705811 3597 1343545
SGTC_1773 st048542 73.5835 µM -0.63000280824508 0.268680541179092 no 2460 0.264346373446917 3512 3237138
SGTC_456 gingerol 170 µM -0.631149493499509 0.268297118188947 no 2461 0.263971391094518 3630 442793 A herb.
SGTC_2299 7976368 114.88 µM -0.632803951484586 0.26774439412889 no 2462 0.263430838012089 3556 2979718
SGTC_952 1185-0122 232 µM -0.633425056961568 0.267537042415231 no 2463 0.263228053198108 3532 678600
SGTC_271 rotenone 740 µM -0.634477226438236 0.267185967856201 no 2464 0.262884712276532 3607 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_173 1273-0061 2.693 µM -0.635565444222583 0.266823109937934 no 2465 0.262529849217443 3522 2847414 YPL266W DIM1
SGTC_2900 5328528 85.29 µM -0.636087145263483 0.266649241051199 no 2466 0.262359811781076 3588 795359
SGTC_165 k038-0023 64.381 µM -0.63822717845381 0.265936625612238 no 2467 0.26166290382387 3560 46368543
SGTC_828 2074-0507 139 µM -0.639309705429811 0.265576519881681 no 2468 0.261310737964386 3617 X828
SGTC_571 k831-0106 44.2 µM -0.639446027706297 0.265531189422154 no 2469 0.261266407097638 3554 4783639
SGTC_3312 9133330 71.43 µM -0.640438091305482 0.265201422498843 no 2470 0.260943912707834 3602 17617324
SGTC_575 k072-0246 11.9 µM -0.64086773667147 0.265058670782704 no 2471 0.260804309590254 3586 6796779
SGTC_3307 9126885 69.2785 µM -0.640935097963365 0.265036293213393 no 2472 0.260782425613761 3571 24824909
SGTC_2769 toremifene 3.73 µM -0.641107099677948 0.264979158220142 no 2473 0.26072655090242 3609 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2855 9016525 58.44 µM -0.642069234129342 0.264659674857608 no 2474 0.260414115430059 3600 43811474
SGTC_666 0272-0154 136 µM -0.64219065383001 0.264619370537466 no 2475 0.260374700322697 3577 6870312
SGTC_2323 6148992 148.28 µM -0.642792339195289 0.264419691865881 no 2476 0.260179427346802 3532 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_958 1222-0007 33 µM -0.643210266283351 0.264281041392456 no 2477 0.260043836331877 3646 7312461
SGTC_1087 pterostilbene 9.05 µM -0.645003588701267 0.263686513641335 no 2478 0.2594624300463 3610 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2932 9016711 44.54 µM -0.645904641622229 0.263388051529272 no 2479 0.259170556709125 3586 7117328
SGTC_3255 9139072 49.47 µM -0.646126225868232 0.263314681048545 no 2480 0.25909880609918 3604 17646060
SGTC_3070 9117005 49.47 µM -0.647402552070274 0.262892270059758 no 2481 0.258685722325033 3622 8779016
SGTC_1214 0358-0031 63.7 µM -0.648144457868356 0.262646889372138 no 2482 0.258445760829556 3638 4301366
SGTC_193 1273-0060 1.558 µM -0.649478044039235 0.262206108956362 no 2483 0.258014716746468 3502 2847393 YHR072W ERG7
SGTC_3191 9110352 49.47 µM -0.649527218618228 0.262189862893084 no 2484 0.257998829583295 3581 17122424
SGTC_668 1682-0499 62.6 µM -0.650579806853089 0.261842237518322 no 2485 0.257658884511482 3598 682214
SGTC_3241 9133421 49.47 µM -0.650774197928717 0.261778064237286 no 2486 0.257596129203181 3594 17018221
SGTC_2882 9058044 58.44 µM -0.652673538023098 0.261151470120077 no 2487 0.256983382791463 3562 18076804
SGTC_2095 5432005 200 µM -0.65337555203718 0.26092007028118 no 2488 0.256757098011645 3606 783734
SGTC_2968 9090663 33.37 µM -0.653525525129664 0.26087064940107 no 2489 0.256708769651368 3555 25236811
SGTC_2260 7964312 200 µM -0.6538236072292 0.2607724362134 no 2490 0.256612727689784 3647 231951
SGTC_1963 st076565 50.3 µM -0.654690287809768 0.260486987214166 no 2491 0.256333589807377 3623 4914280
SGTC_543 3844-1095 191 µM -0.655811768967256 0.260117856322938 no 2492 0.255972621546508 3600 4230703
SGTC_2105 5350118 200 µM -0.656009493810346 0.260052803980672 no 2493 0.255909007871027 3627 2133313
SGTC_2907 7721985 69.9 µM -0.656625274174006 0.25985026328942 no 2494 0.255710946774584 3564 3267881
SGTC_162 k030-0015 37.8 µM -0.657146331328621 0.259678942271527 no 2495 0.255543415220029 3644 1809920 YMR134W ERG29
SGTC_619 1652-1634 108 µM -0.658090193903294 0.259368753447892 no 2496 0.255240088310289 3552 5400454
SGTC_1767 st044992 70.3 µM -0.660801959209275 0.258478631373878 no 2497 0.2543696631033 3577 9600693
SGTC_2190 6049624 200 µM -0.66246047892194 0.257935012237896 no 2498 0.253838077517624 3557 2265554
SGTC_654 1124-0271 80.9 µM -0.664626121894006 0.257226065399619 no 2499 0.253144828628003 3618 5403748
SGTC_1328 1441-0025 69.2 µM -0.664991215677381 0.25710664782944 no 2500 0.253028055795842 3568 4562601
SGTC_1228 0124-0032 52.5 µM -0.66564849074469 0.256891734143529 no 2501 0.252817902171912 3652 X1228
SGTC_2394 5221648 200 µM -0.666391246908756 0.256648982679178 no 2502 0.252580527916005 3669 788586
SGTC_1154 4088-0362 150 µM -0.66685126134396 0.256498698269902 no 2503 0.252433572774035 3630 6618304
SGTC_341 1486-1430 230 µM -0.66702040412384 0.256443451701385 no 2504 0.252379550147256 3593 2054753 YPL210C SRP72
SGTC_548 1436-0017 110 µM -0.667655620093847 0.256236028505659 no 2505 0.252176722518768 3675 9677137
SGTC_2962 9082311 13.18 µM -0.670251969391562 0.255389127807115 no 2506 0.251348589872044 3610 16459453
SGTC_189 3970-0742 2.116 µM -0.670299985430435 0.25537347928987 no 2507 0.251333288207411 3642 2891807
SGTC_2177 5811945 192 µM -0.670598311913807 0.255276265358788 no 2508 0.25123822909796 3662 5343475
SGTC_1218 1348-1416 30.7 µM -0.671069250145792 0.255122842817343 no 2509 0.251088207476922 3626 6787668
SGTC_2653 dihydrofissinolide 100 µM -0.671367782394767 0.255025611782023 no 2510 0.250993131884944 3647 6857746
SGTC_2818 7996756 12.99 µM -0.672826869899291 0.254550670539063 no 2511 0.250528720607857 3631 2241621
SGTC_2791 5663188 71.43 µM -0.673359895115007 0.254377283439927 no 2512 0.250359178242006 3613 54690634
SGTC_2387 9077560 195.08 µM -0.673794462227716 0.254235969472011 no 2513 0.250220998025888 3624 5303272
SGTC_147 4466-0538 29.23 µM -0.675829309352874 0.25357481919214 no 2514 0.249574511856766 3707 6742687 YHR072W ERG7
SGTC_2868 9035608 32.47 µM -0.678583159095015 0.252681495299642 no 2515 0.248701008238502 3641 6462614
SGTC_1287 0971-0001 34.6 µM -0.68030855336952 0.252122638742871 no 2516 0.248154554894 3649 4665869
SGTC_2949 9072542 2.23 µM -0.68311128473469 0.251216223462684 no 2517 0.247268262605457 3668 16457352
SGTC_918 glabranin 770.725 nM -0.683589329255861 0.251061794038839 no 2518 0.247117262352902 3671 124049 Also referred to as licorice root.
SGTC_2064 5220758 200 µM -0.684464118045393 0.250779328849802 no 2519 0.246841069974992 3691 788518
SGTC_1028 k015-0029 4.8 µM -0.68447184726552 0.250776833871093 no 2520 0.24683863040638 3652 4588309
SGTC_2368 9071271 200 µM -0.685037827151542 0.250594172279433 no 2521 0.246660025630868 3640 27209959
SGTC_1340 1486-1359 257 µM -0.685782850551873 0.250353834551954 no 2522 0.246425026123941 3616 4309068
SGTC_2594 a-mangostin 100 µM -0.685988296727045 0.250287580996774 no 2523 0.246360244237495 3672 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_677 0929-0063 136 µM -0.686317610947112 0.250181401103609 no 2524 0.246256422963913 3613 1539583
SGTC_2734 clemastine 41.6 µM -0.686774714524116 0.250034058037642 no 2525 0.246112353055603 3641 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_979 1426-2828 121 µM -0.686928439507763 0.249984516573607 no 2526 0.246063912174538 3724 747872
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.686930149478823 0.249983965524817 no 2527 0.246063373367631 3711 5024745
SGTC_3353 9151644 39.2805 µM -0.687840876818711 0.249690569601025 no 2528 0.245776495785523 3671 4909158
SGTC_1428 4049-0204 61.7 µM -0.687933232251472 0.249660826996458 no 2529 0.245747414010225 3698 X1428
SGTC_1248 0469-0687 58.6 µM -0.688727588433757 0.24940508628226 no 2530 0.245497355725643 3658 4017482
SGTC_510 ag-490 170 µM -0.690241445696545 0.248918090035149 no 2531 0.245021181828139 3758 5328779
SGTC_754 3474-0146 171 µM -0.691049476605893 0.248658360016078 no 2532 0.244767224516623 3618 24762078
SGTC_2058 5236698 133 µM -0.691613724835519 0.248477076091815 no 2533 0.244589970106322 3669 766665
SGTC_409 arachidonic acid 100 µM -0.693365006964639 0.247914865992523 no 2534 0.244040258338025 3687 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1561 5-methoxyflavone 52.9 µM -0.695342528814809 0.247280843724994 no 2535 0.243420333926388 3630 94525
SGTC_2005 4024620 188 µM -0.695984481176827 0.247075211004034 no 2536 0.243219274262291 3671 236743
SGTC_1485 3909-9022 254 µM -0.69609149826134 0.247040939766034 no 2537 0.243185765213515 3692 714516
SGTC_873 0591-4978 488 µM -0.69972953994646 0.245877404608858 no 2538 0.242048112432417 3718 3305145
SGTC_849 0386-0493 241 µM -0.70114013119559 0.245427055418323 no 2539 0.24160778387651 3643 726119
SGTC_2893 9048488 25.97 µM -0.703068853876662 0.244812004258174 no 2540 0.241006420562026 3652 6467338
SGTC_1266 0828-0227 32.9 µM -0.70398438539184 0.244520340684506 no 2541 0.240721248882155 3670 3913820
SGTC_3051 9093778 49.47 µM -0.704006603764992 0.244513264839089 no 2542 0.240714330539747 3697 17217378
SGTC_1563 conessine 56.1 µM -0.704334146721732 0.244408965621799 no 2543 0.240612352987 3755 441082 An anti-amoebic, histamine inhibitor.
SGTC_2071 5230951 39.92 µM -0.707225281040242 0.243489384840603 no 2544 0.239713245139078 3727 1799272
SGTC_2652 actinonin 100 µM -0.707881942462525 0.243280781838549 no 2545 0.239509287168155 3672 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1268 0828-0275 2.46 µM -0.708535716383299 0.243073192113123 no 2546 0.239306320211705 3738 745337
SGTC_1128 3448-9350 235 µM -0.708609890443212 0.243049646028779 no 2547 0.239283298488669 3727 619386
SGTC_2984 9022109 38.96 µM -0.70971094674513 0.242700267808074 no 2548 0.238941701220567 3737 6459207
SGTC_2507 purpurin 79.67 µM -0.710511230972641 0.242446498853679 no 2549 0.23869358444036 3695 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_399 oxolinic acid 75 µM -0.71146593631612 0.242143951309422 no 2550 0.238397776078947 3677 4628 A DNA gyrase inhibitor.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.712978744134599 0.241664959713754 no 2551 0.237929455165041 3643 140250 A respiratory chain inhibitor.
SGTC_1531 st059297 52.4 µM -0.713828868848981 0.24139601554584 no 2552 0.23766650303042 3708 7566702
SGTC_2300 7976697 71.57 µM -0.714401738698574 0.241214875049042 no 2553 0.237489398579115 3639 2236109
SGTC_1256 0570-0116 285 µM -0.714862370273288 0.241069277709633 no 2554 0.237347045490314 3705 410638
SGTC_1725 st036284 20.55 µM -0.715054091907893 0.241008692042194 no 2555 0.237287809853725 3712 707914
SGTC_2695 st077686 51.995 µM -0.715298736555503 0.240931394278384 no 2556 0.237212234550447 3715 2876092
SGTC_1865 st057639 52.2 µM -0.716886780614678 0.240429964927056 no 2557 0.236721979688335 3698 688818
SGTC_2414 st077232 92.9 µM -0.718736099330653 0.239846754454623 no 2558 0.236151768182623 3683 729801
SGTC_1097 itavastatin 7.23 µM -0.718872222772911 0.239803856393434 no 2559 0.236109826342772 3720 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3146 9095609 49.47 µM -0.720018653945196 0.239442735199159 no 2560 0.235756755177274 3767 17173999
SGTC_2589 lobaric acid 100 µM -0.720738130655363 0.239216254693802 no 2561 0.235535323718875 3707 73157 A novel microtubule depolymerizer.
SGTC_746 1095-0025 46.6 µM -0.721043319157815 0.239120221286879 no 2562 0.235441431325723 3710 6749286
SGTC_2874 9043904 71.43 µM -0.721901643577127 0.238850246070876 no 2563 0.23517747535267 3696 4463428
SGTC_3074 9116018 49.47 µM -0.723118177733309 0.238467886228193 no 2564 0.234803641149881 3756 17027303
SGTC_2873 9040596 71.43 µM -0.723460709194725 0.23836028819496 no 2565 0.234698442426341 3685 6463863
SGTC_2134 5324836 1.464 µM -0.72386128129437 0.23823449182378 no 2566 0.234575451249478 3693 699272
SGTC_1213 1315-0166 115 µM -0.724906253158355 0.237906498273896 no 2567 0.234254772204299 3740 768401
SGTC_802 4112-3352 742 µM -0.725196634333439 0.237815398028774 no 2568 0.234165703669809 3793 704594
SGTC_3182 9108849 49.47 µM -0.725749324289633 0.237642057464138 no 2569 0.23399622905926 3744 17133045
SGTC_85 0868-0259 160.055 µM -0.72600796306084 0.237560964210379 no 2570 0.233916944456509 3686 83173
SGTC_887 0885-0007 9.62 µM -0.727611067654923 0.237058667891967 no 2571 0.233425851819581 3765 5719458
SGTC_1065 prochlorperazine maleate 2.48 µM -0.728612051823178 0.236745328522195 no 2572 0.233119502141384 3759 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1629 st005085 44.9 µM -0.728741218428349 0.23670491193222 no 2573 0.233079987165704 3721 24207091
SGTC_294 k038-0071 157 µM -0.728862612400264 0.236666930880568 no 2574 0.233042853404058 3727 24152826
SGTC_1765 st044815 90.4 µM -0.729792234073815 0.236376187333316 no 2575 0.232758596078012 3742 645695
SGTC_45 0kpi-0036 14.9 µM -0.729894510617638 0.236344211874628 no 2576 0.232727333988961 3693 2795021
SGTC_2947 9072639 7.68 µM -0.730574212868993 0.236131772136751 no 2577 0.232519633895077 3731 16488146
SGTC_1943 st076331 65.2 µM -0.73058556042454 0.236128226371263 no 2578 0.232516167239453 3765 24208415
SGTC_244 nsc-207895 1.295 µM -0.731070964340759 0.235976579896419 no 2579 0.232367904220889 3597 42640
SGTC_2448 5185112 27.17 µM -0.731116317130214 0.235962413839279 no 2580 0.232354054235259 3712 5718189
SGTC_2656 pseudo-anisatin 100 µM -0.731145077159314 0.235953430815149 no 2581 0.232345271639896 3769 6708809 A neurotoxin.
SGTC_616 4092-0450 108 µM -0.732975315672025 0.235382154501457 no 2582 0.231786742435122 3768 787165
SGTC_2216 7189485 200 µM -0.734073316979943 0.235039799687211 no 2583 0.231452027477948 3720 731273
SGTC_101 0490-5701 117.494 µM -0.734224483254801 0.234992687869482 no 2584 0.231405967033136 3615 4661669
SGTC_855 0428-0020 25 µM -0.735972131634387 0.234448402451984 no 2585 0.230873828940844 3750 6812414
SGTC_3007 9078383 71.4286 µM -0.736168555207966 0.234387272174078 no 2586 0.230814063050183 3737 6496995
SGTC_2233 sulbentine 40.3845 µM -0.736186320644657 0.234381743710151 no 2587 0.230808657978748 3704 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1426 4048-4480 71.7 µM -0.736231273070038 0.234367755191857 no 2588 0.230794981677661 3700 14224343
SGTC_2513 baicalein 25.65 µM -0.737974952526721 0.233825505072421 no 2589 0.230264835010214 3731 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_302 1094-0063 18.9 µM -0.742201759774467 0.232513940889679 no 2590 0.228982551266497 3699 5440289
SGTC_357 1325-0123 420 µM -0.744955125038895 0.231661785936714 no 2591 0.228149424300603 3737 1098503
SGTC_776 4476-4378 112 µM -0.745641948109692 0.23144948863406 no 2592 0.227941867876948 3804 2892008
SGTC_2245 6637752 200 µM -0.745788984639157 0.231404053681902 no 2593 0.22789744756933 3784 681890
SGTC_2472 5377652 49.4 µM -0.745804860446382 0.231399148283236 no 2594 0.227892651717538 3802 1610903
SGTC_2211 7117706 200 µM -0.747965866625338 0.230731969519877 no 2595 0.227240373148742 3679 822771
SGTC_84 0443-0269 128.823 µM -0.748214450062187 0.230655292025236 no 2596 0.227165408205989 3666 6150058
SGTC_3337 9144342 33.5465 µM -0.749408569778712 0.230287155035561 no 2597 0.226805493651 3762 17682949
SGTC_125 0133-0007 11.75 µM -0.750174313784978 0.230051255669002 no 2598 0.226574863402693 3828 26541
SGTC_3216 9129716 49.47 µM -0.751905911589033 0.229518308939873 no 2599 0.226053821412281 3748 8056934
SGTC_252 miconazole 1.30953 nM -0.753065094276324 0.229161925586061 no 2600 0.225705399310019 3716 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2367 9070478 135.38 µM -0.753239880344404 0.229108215658638 no 2601 0.225652889243751 3732 572802
SGTC_3288 9119690 36.221 µM -0.753789326604833 0.228939422573308 no 2602 0.225487866995223 3759 17595618 YKL019W RAM2
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.754458563739804 0.228733923330308 no 2603 0.225286958721238 3770 5106787 A p450 inhibitor.
SGTC_504 lovastatin 124 µM -0.755026406568551 0.228559639967513 no 2604 0.225116569045862 3769 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_523 1934-0222 13.7 µM -0.755355739874165 0.228458594569677 no 2605 0.22501778115736 3751 1361595
SGTC_463 ikarugamyin 104 µM -0.755698253309308 0.228353531900536 no 2606 0.224915065780981 3799 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2841 9004761 38.96 µM -0.755748565052249 0.228338101549588 no 2607 0.224899980175058 3735 2991039
SGTC_1050 3232-1156 69.3 µM -0.756154638651734 0.228213582333458 no 2608 0.224778242993147 3744 700529
SGTC_1784 st039334 36.3 µM -0.756239499000021 0.22818756541069 no 2609 0.22475280735144 3807 3496984
SGTC_1661 st013063 9.66 µM -0.756255272762932 0.228182729592986 no 2610 0.224748079577826 3805 721395
SGTC_2963 9082507 9 µM -0.756550296971142 0.228092293606393 no 2611 0.224659664166257 3794 16459611
SGTC_689 0833-0039 98 µM -0.756684018813559 0.228051309484981 no 2612 0.224619595744197 3749 5374726
SGTC_194 1486-1323 56.904 µM -0.757908524127447 0.227676206136011 no 2613 0.224252873462937 3795 5178754
SGTC_1736 st036774 51 µM -0.758868375531619 0.227382417353064 no 2614 0.223965649171092 3844 1272247
SGTC_433 pimozide 108 µM -0.75929965842914 0.22725048099418 no 2615 0.223836660904879 3698 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1011 4112-3381 17.4 µM -0.759664151071818 0.227139010491811 no 2616 0.223727681224188 3848 2877139
SGTC_364 0083-0097 67.7 µM -0.759915730913382 0.227062089386811 no 2617 0.22365247894874 3847 5207356
SGTC_1746 st038117 42 µM -0.760505529264822 0.226881814797417 no 2618 0.223476232717067 3828 2898218
SGTC_1373 2887-0003 58.5 µM -0.76072809051486 0.226813808910004 no 2619 0.223409746487969 3777 776948
SGTC_556 4058-0063 51.5 µM -0.762834206457619 0.226170833055472 no 2620 0.222781139101568 3834 6615692
SGTC_829 1635-0120 117 µM -0.764227921028827 0.225745913046894 no 2621 0.222365715217842 3803 285054
SGTC_2082 5219693 150 µM -0.764325130506783 0.225716292377448 no 2622 0.222336756526465 3768 2834649
SGTC_2256 7954252 200 µM -0.7648381406595 0.225560009639643 no 2623 0.222183966506635 3778 2972920
SGTC_340 k038-0059 454 µM -0.765087911080402 0.225483942078755 no 2624 0.222109598976043 3775 23733424
SGTC_1410 3909-8106 77.9 µM -0.766689348808565 0.224996569509442 no 2625 0.221633118946867 3802 1039210
SGTC_2588 indole-3-carbinol 100 µM -0.770567380125302 0.22381882796121 no 2626 0.220481701136811 3808 3712 Induces cell cycle arrest.
SGTC_753 1322-0200 289 µM -0.770651688351274 0.223793262890384 no 2627 0.220456707497135 3819 5403907
SGTC_2664 lyso-paf C-16 73.48 µM -0.770996071790888 0.223688851565527 no 2628 0.220354629987366 3765 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_868 0527-0199 213 µM -0.772146812092884 0.223340167234362 no 2629 0.220013739608988 3753 2849450
SGTC_723 4182-0001 115 µM -0.772202597260756 0.223323271706975 no 2630 0.219997221742629 3768 744821 YLR208W SEC13
SGTC_1415 3966-0071 78.1 µM -0.773134255307206 0.223041210078587 no 2631 0.219721465017002 3753 2893185
SGTC_539 4859-0462 2.54 µM -0.773293466708132 0.222993028764193 no 2632 0.21967436070656 3852 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1378 2093-0007 380 nM -0.774269406562252 0.222697814756994 no 2633 0.219385745725428 3859 3618014
SGTC_1724 st037281 8.293 µM -0.775010203856277 0.222473878289877 no 2634 0.219166815062008 3808 574124 YDL195W SEC31
SGTC_2591 skatole 100 µM -0.775715683282395 0.222260737531943 no 2635 0.218958438836955 3833 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_554 4483-2211 187 µM -0.776094937711012 0.222146204647917 no 2636 0.218846466232931 3833 747107
SGTC_3098 9119039 49.47 µM -0.776335344116083 0.222073620599219 no 2637 0.218775504742682 3782 17161528
SGTC_2333 9017922 200 µM -0.776736788699964 0.221952445720852 no 2638 0.218657038643823 3829 3163164
SGTC_678 1218-2179 85.9 µM -0.777729505813126 0.221652959125134 no 2639 0.218364246921658 3775 6820081 YOR116C RPO31
SGTC_581 0958-0271 211 µM -0.778261184627409 0.221492655284112 no 2640 0.218207526626336 3819 4591145
SGTC_1526 st051518 75 µM -0.778323547547845 0.221473856893149 no 2641 0.218189148469368 3800 673993
SGTC_860 0443-0016 25.1 µM -0.779308486639345 0.221177082381375 no 2642 0.217899008325818 3824 5337942
SGTC_1864 st057645 30.4 µM -0.780124727910018 0.220931311130994 no 2643 0.217658731320119 3825 688666
SGTC_693 4161-2696 114 µM -0.781502576714084 0.220516794051455 no 2644 0.217253480906865 3849 805759
SGTC_2292 7671323 168.05 µM -0.781933079694696 0.220387371390888 no 2645 0.217126951552726 3829 937504
SGTC_2294 7971431 200 µM -0.781966443273804 0.22037734307375 no 2646 0.217117147423847 3767 5741572
SGTC_46 0329-0187a 2.197 µM -0.782447017169594 0.220232922742186 no 2647 0.216975955689516 3864 46494817
SGTC_2044 5102272 200 µM -0.78482976281167 0.219517670725439 no 2648 0.216276693653113 3805 592666
SGTC_2661 dactinomycin 12.96 µM -0.784959135661126 0.219478873843418 no 2649 0.216238764108121 3800 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1277 0873-0036 22 µM -0.785364159891444 0.21935743892215 no 2650 0.216120043969047 3858 5965735
SGTC_1296 1068-0102 11.9 µM -0.785889188859972 0.219200081493612 no 2651 0.215966204405246 3826 767053
SGTC_3257 9139206 32.98 µM -0.786191530609597 0.219109495525333 no 2652 0.215877643568153 3829 4910041
SGTC_3115 9123671 49.47 µM -0.787880952356733 0.218603716638352 no 2653 0.215383171835102 3896 3286988
SGTC_645 0845-0943 5.41 µM -0.78910569497433 0.218237473961706 no 2654 0.215025116846075 3830 1885106
SGTC_942 3253-1115 227 µM -0.790630478767768 0.217782002503586 no 2655 0.214579827833762 3856 46497897
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.792163272725412 0.217324691468091 no 2656 0.214132740305588 3820 61125 An anti-inflammatory.
SGTC_1828 st055811 49 µM -0.793709839387262 0.216863833869554 no 2657 0.213682185405234 3845 5877589
SGTC_2616 abietic acid 100 µM -0.795756046753529 0.216254958681784 no 2658 0.213086921723154 3821 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2451 5856223 45.7 µM -0.796062055102915 0.21616398713254 no 2659 0.212997983834674 3809 2179896
SGTC_1302 1159-0335 255 µM -0.798042653509765 0.215575722001256 no 2660 0.21242286914389 3841 649284
SGTC_589 1227-0070 34.1 µM -0.79869662168894 0.215381688467552 no 2661 0.212233173082239 3864 2841384
SGTC_2135 5326629 150.42 µM -0.800160681604502 0.214947666780873 no 2662 0.21180885347173 3797 5020077
SGTC_1182 1222-0449 220 µM -0.800211576901853 0.214932587972458 no 2663 0.211794111729527 3835 658318
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.800313969571025 0.214902253839708 no 2664 0.211764455674141 3781 97141
SGTC_230 MPP+ 141.667 µM -0.80429796479532 0.213723915393526 no 2665 0.210612456391384 3828 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_853 0419-0306 21 µM -0.805626009653045 0.213331960077277 no 2666 0.210229261908557 3850 762713
SGTC_1763 st044482 94.5 µM -0.806192324261498 0.213164947161646 no 2667 0.210065981921616 3880 88505
SGTC_1189 1431-2119 7.28 µM -0.807864273968892 0.212672314444562 no 2668 0.20958435981168 3859 3107275
SGTC_1006 4099-6547 255 µM -0.810306487454888 0.211953922890411 no 2669 0.20888202384274 3893 3146833
SGTC_905 2-aminofluorene 215 µM -0.811485053697655 0.211607749034231 no 2670 0.208543586354721 3857 1539 An established DNA mutagen. YPR165W RHO1
SGTC_192 3455-0609 60.9 µM -0.813472894616739 0.211024621828164 no 2671 0.207973490374762 3922 3769639
SGTC_1708 st033234 31.827 µM -0.815013337683277 0.210573385963097 no 2672 0.207532337766111 3947 674664
SGTC_57 miconazole 162.5 nM -0.819063885770813 0.209389580228955 no 2673 0.206374982573915 3807 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_483 fpl-64176 144 µM -0.819254473909396 0.209333975927784 no 2674 0.206320620575967 3889 3423
SGTC_112 phenothiazine 287.218 µM -0.820108308398686 0.209084975460941 no 2675 0.206077183125186 3791 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_696 1560-0013 611 µM -0.820351926079672 0.209013962167741 no 2676 0.206007756332233 3888 1650269
SGTC_1744 st037937 38.9 µM -0.821338163628729 0.208726624216182 no 2677 0.205726837603111 3928 1016152
SGTC_2789 5281112 71.43 µM -0.821977820649222 0.20854038619785 no 2678 0.205544760059441 3890 765948
SGTC_1474 0330-0125 5.35 µM -0.822184812772827 0.20848014082254 no 2679 0.205485860514604 3856 X1474
SGTC_1791 st048313 56.1 µM -0.823573427540357 0.208076247808863 no 2680 0.205090989811755 3814 1204976
SGTC_3219 9131112 49.47 µM -0.823823972492321 0.208003423423892 no 2681 0.205019792145174 3823 17612988 YMR079W SEC14
SGTC_373 0844-0104 25.9 µM -0.825441589218011 0.20753360286171 no 2682 0.2045604657728 3917 5375804
SGTC_1824 st053723 68.6 µM -0.82565037245514 0.207473009593163 no 2683 0.204501225893388 3892 675225
SGTC_2943 9068529 45.32 µM -0.825885254994617 0.207404854261227 no 2684 0.204434592837961 3879 3270634
SGTC_2317 5986382 200 µM -0.826067073597643 0.207352105460317 no 2685 0.20438302219077 3894 877883
SGTC_2409 alverine citrate 63.97 µM -0.826452482507777 0.207240317730994 no 2686 0.204273731225775 4052 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2183 6420625 130.508 µM -0.826624977698423 0.207190297104717 no 2687 0.204224827788497 3859 2897619
SGTC_126 0417-1624 672.48 µM -0.827539683970001 0.206925167438595 no 2688 0.203965619520045 3930 41912 YDL195W SEC31
SGTC_2146 5545642 200 µM -0.828278633452892 0.206711127968814 no 2689 0.203756360203483 3850 825326
SGTC_2618 avocadyne 43.43 µM -0.829268428953616 0.206424635507335 no 2690 0.203476265708626 3807 3015189
SGTC_3319 9138450 16.7555 µM -0.829271229214064 0.206423825316711 no 2691 0.203475473610761 3815 2029690
SGTC_955 1216-0110 33 µM -0.831356330051057 0.205821072757674 no 2692 0.202886180665527 3834 3619719
SGTC_2374 9071832 200 µM -0.8315896415164 0.205753693040825 no 2693 0.202820305460114 3804 17381698
SGTC_3036 9090181 49.47 µM -0.832854269301097 0.205388699801227 no 2694 0.202463461759932 3895 25236586
SGTC_1034 k072-0165 12.7 µM -0.834537226629968 0.204903566346928 no 2695 0.20198915941807 3907 5835461
SGTC_2053 5265679 138 µM -0.835041188614313 0.204758425681269 no 2696 0.201847258963113 3833 764595
SGTC_2274 7947094 46.08 µM -0.83586157543521 0.204522285739365 no 2697 0.20161639054855 3845 2971028
SGTC_441 propafenone 146 µM -0.835916900658854 0.20450636677583 no 2698 0.201600826946504 3857 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1251 0490-5699 265 µM -0.838290305586915 0.203824151378264 no 2699 0.200933839612006 3904 3883818
SGTC_775 4577-0580 57.3 µM -0.840039297061279 0.203322287635188 no 2700 0.200443176754364 3979 2006902
SGTC_413 propylparaben 100 µM -0.840089959253088 0.203307761388091 no 2701 0.200428974693495 3849 7175 A pharmaceutical preservative.
SGTC_2655 perillic acid 100 µM -0.840719998259339 0.203127163582678 no 2702 0.200252407248159 3920 5702197 An apoptosis inducer.
SGTC_1706 st031321 9.9705 µM -0.843859686612683 0.202228615037178 no 2703 0.199373908852348 3914 6103185
SGTC_718 1130-0073 349 µM -0.846967374938219 0.201341570325987 no 2704 0.19850665323928 3949 6740020
SGTC_1080 nisoldipine 24.4 µM -0.847134612998526 0.201293900864239 no 2705 0.198460047109098 3878 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1887 st057648 70.8 µM -0.847498571295782 0.2011901817419 no 2706 0.198358641535645 3920 688672
SGTC_1628 st004252 77.7 µM -0.849000106261349 0.200762620308462 no 2707 0.197940616575369 3928 692968
SGTC_1892 st058411 7.36 µM -0.849106676163263 0.200732295316211 no 2708 0.197910967920366 3927 3934738
SGTC_1873 rapamycin 2 nM -0.850475647574115 0.20034299229718 no 2709 0.197530347016221 3873 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3311 9131146 2.8755 µM -0.850719221733941 0.200273773143325 no 2710 0.197462671468955 3889 4900406 YPR165W RHO1
SGTC_1755 st041960 45.185 µM -0.852500378760535 0.199768039009751 no 2711 0.196968214438875 3971 2257073
SGTC_2909 7941780 10.49 µM -0.852953909484275 0.199639388245084 no 2712 0.196842432132113 3858 1243215
SGTC_557 1315-0110 16.2 µM -0.855346233074481 0.198961595383019 no 2713 0.196179749880845 3896 6833801
SGTC_1545 lovastatin 49.4 µM -0.858640761014934 0.198030463265178 no 2714 0.195269371249874 4003 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_472 calcifediol 10 µM -0.858749501322752 0.197999774932837 no 2715 0.195239366810646 3944 5283731 A vitamin D metabolite.
SGTC_996 3970-0799 1.8 µM -0.858970553259928 0.197937399236055 no 2716 0.195178381143193 3951 6615648 YGL040C HEM2
SGTC_2892 9047358 58.44 µM -0.859148315935777 0.197887247369608 no 2717 0.195129346880652 3909 6466771
SGTC_1527 coumarin 137 µM -0.859731143444935 0.197722869135691 no 2718 0.1949686315908 4037 323 A hepatotoxic, DNA x-linker.
SGTC_1246 0422-0085 105 µM -0.86079298446028 0.19742360412673 no 2719 0.194676034796452 3952 264295
SGTC_2885 9057732 51.95 µM -0.861067201155111 0.197346364519018 no 2720 0.194600516134453 3965 6471414
SGTC_35 0133-0054 64.071 µM -0.861733423575608 0.197158783401525 no 2721 0.19441711425778 3933 99677
SGTC_3309 9129340 25.759 µM -0.862000047318895 0.197083743244673 no 2722 0.194343745896712 3953 17158987
SGTC_1984 st072354 53.1 µM -0.862441546721528 0.1969595230657 no 2723 0.194222293088166 3815 5762938
SGTC_538 2922-0838 53.3 µM -0.863538754795271 0.196651018152231 no 2724 0.193920660533141 3899 777039
SGTC_3263 9137018 49.47 µM -0.865238860861058 0.19617357337239 no 2725 0.193453850053306 3946 43844957
SGTC_1370 2001-0092 44.6 µM -0.866060323823614 0.195943132093067 no 2726 0.193228540848426 3980 790957
SGTC_741 4582-0002 126 µM -0.86699862583005 0.195680115516276 no 2727 0.192971381311654 3887 2912688
SGTC_1350 1495-0454 146 µM -0.868438947236415 0.195276794518175 no 2728 0.192577040686869 3967 1069057
SGTC_55 0767-0285 6.563 µM -0.868537918946163 0.195249098867917 no 2729 0.19254996166204 3852 3116166
SGTC_3330 9141424 71.43 µM -0.868549601577983 0.195245829827733 no 2730 0.192546765404476 4006 27261020
SGTC_152 4469-0003 551.229 µM -0.869878598202641 0.194874166414752 no 2731 0.192183376220528 3852 697280
SGTC_2961 9083290 32.55 µM -0.870245404746637 0.194771662153794 no 2732 0.192083153781776 3865 17741490
SGTC_2161 5662504 8.5105 µM -0.870336434455125 0.194746228939483 no 2733 0.192058286716594 3895 2859334
SGTC_1318 1280-3875 124 µM -0.871617884011769 0.19438841321287 no 2734 0.191708435479725 3954 373245
SGTC_394 menadione 8.33 µM -0.871962418085697 0.194292278200707 no 2735 0.19161444011912 3934 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2370 9071495 200 µM -0.87229644607916 0.194199102335407 no 2736 0.191523337970001 3950 21791103
SGTC_1608 st001473 40.5 µM -0.872448405664333 0.194156722783029 no 2737 0.191481901589942 3910 7292267
SGTC_2830 7992007 71.43 µM -0.874325626945798 0.193633654932138 no 2738 0.19097047353906 3825 1952075
SGTC_1859 st055998 20 µM -0.875439996724993 0.193323554451478 no 2739 0.190667272587826 3882 676301
SGTC_876 0720-0963 56.8 µM -0.8780067691723 0.192610441420848 no 2740 0.189970022613461 3990 765861
SGTC_2774 tamoxifen 10.92 µM -0.878161169062463 0.192567596627442 no 2741 0.189928130748082 3956 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_771 0250-0039 27.3 µM -0.880781951843621 0.191841238296946 no 2742 0.189217925072 3899 3005115
SGTC_3229 9132204 49.47 µM -0.882310478858185 0.191418377623401 no 2743 0.188804465642292 3988 17682924
SGTC_2391 6285546 200 µM -0.88249051887686 0.191368607924018 no 2744 0.188755802335193 3934 846083
SGTC_78 0336-0123 156.75 µM -0.883080883674304 0.191205464971982 no 2745 0.188596285923273 3781 6765896
SGTC_1626 st003712 1.76 µM -0.883361394118594 0.191127977872864 no 2746 0.188520521211921 3962 24207035
SGTC_1986 st071812 45 µM -0.885304362486634 0.190591788689882 no 2747 0.187996248872004 3885 11838594
SGTC_209 4077-0173 175.592 µM -0.886966742332321 0.190133765608255 no 2748 0.187548403137678 3922 15993494
SGTC_2116 5511452 16.8835 µM -0.886997327892033 0.190125344939445 no 2749 0.187540169557841 4003 870744
SGTC_2572 astragaloside iv 100 µM -0.887721676166118 0.189925987851863 no 2750 0.187345241542658 4031 45006101 An anti-inflammatory agent.
SGTC_1614 st002383 48.6 µM -0.887913021269495 0.189873346801038 no 2751 0.187293769939233 3953 1947235
SGTC_2033 5192550 145 µM -0.888563226202343 0.189694535627459 no 2752 0.187118930934882 3934 182073
SGTC_3031 9088762 49.47 µM -0.888603714592881 0.189683404446795 no 2753 0.187108047015057 3934 205253
SGTC_599 1935-0052 86.5 µM -0.889079949757588 0.189552506710638 no 2754 0.186980056861039 3958 9557311
SGTC_3160 9100216 49.47 µM -0.889144537835625 0.189534758347819 no 2755 0.186962702722352 3852 17191039
SGTC_2449 5812982 45.77 µM -0.889369873857762 0.189472845554585 no 2756 0.186902165101918 3923 776185
SGTC_2417 cerulenin 830 nM -0.890038068444933 0.189289327169788 no 2757 0.186722722693127 3985 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1025 k007-0731 70 µM -0.892474694096544 0.188621040080802 no 2758 0.186069275398544 3928 6256118
SGTC_1337 1486-1011 40.3 µM -0.894548199752196 0.1880534920838 no 2759 0.18551432647212 3949 X1337
SGTC_2069 5228469 200 µM -0.895013717082774 0.187926218408499 no 2760 0.18538987768171 3985 2835210
SGTC_1157 4092-0394 27.6 µM -0.89600633387209 0.187655012002106 no 2761 0.18512469020549 4062 3659885
SGTC_2953 9074162 66.49 µM -0.898282383167426 0.18703405493126 no 2762 0.184517511061022 3939 16451992
SGTC_1927 st060202 13.8 µM -0.899299147857977 0.186757070049985 no 2763 0.184246670575938 3855 688887
SGTC_3054 9094397 49.47 µM -0.899383362636142 0.186734139830195 no 2764 0.184224248981351 3992 2598354
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.900309035005674 0.186482210211303 no 2765 0.183977907125625 3955 15053
SGTC_6 0844-0013 19.835 µM -0.900831620379948 0.186340077163156 no 2766 0.183838926245124 4099 1584900
SGTC_1463 k081-0032 34.1 µM -0.901718367806543 0.186099052739583 no 2767 0.18360324662409 3701 977755
SGTC_1357 1503-1303 39.5 µM -0.902044918026654 0.186010342713004 no 2768 0.183516503602967 3941 292895
SGTC_2239 6685329 187.64 µM -0.902865463526291 0.185787550575396 no 2769 0.183298651122537 4035 805680
SGTC_391 gliotoxin 8.33 µM -0.904497417999651 0.185344939233984 no 2770 0.182865851432147 4069 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1511 0906-3109 28.5 µM -0.905581903259485 0.185051172414756 no 2771 0.182578595432566 3994 2882180
SGTC_1183 1254-0324 198 µM -0.90620010599889 0.184883842345292 no 2772 0.182414973468678 4062 5799357
SGTC_2587 piperic acid 92.2 µM -0.90789577665158 0.184425354949662 no 2773 0.181966644589459 3981 5370536
SGTC_856 0433-0016 11.3 µM -0.908039666694067 0.184386481527642 no 2774 0.18192863235038 4032 3911780
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.908939749826397 0.184143430209362 no 2775 0.181690965046181 4019 6708561
SGTC_1775 st081588 35.1725 µM -0.909087998232747 0.184103417520475 no 2776 0.181651838637881 3989 1426443 YGL099W LSG1
SGTC_3189 9110682 49.47 µM -0.909618417512077 0.183960300098026 no 2777 0.181511891099951 4076 17122418
SGTC_1684 st024538 14.6195 µM -0.915215756378363 0.182454255013139 no 2778 0.180039187256987 3972 6732859
SGTC_2264 7948757 110.76 µM -0.918461230781237 0.181584551114343 no 2779 0.179188723498718 3947 2971411
SGTC_2727 riluzole 51.77 µM -0.918916965187356 0.181462634053712 no 2780 0.179069502746749 4001 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_290 2043-6722 48.1 µM -0.920023705868227 0.181166774612454 no 2781 0.178780185663289 4010 773758 YLR208W SEC13
SGTC_1808 st050063 61.5 µM -0.923733602681121 0.180177232160701 no 2782 0.177812516170342 3953 4011993
SGTC_74 000s-0487 160.283 µM -0.924111620671435 0.180076594056545 no 2783 0.17771410180746 3905 677548
SGTC_590 k048-0076 22.4 µM -0.924301701297948 0.180026003045418 no 2784 0.177664628621616 4012 6832814
SGTC_2301 7769476 200 µM -0.924645659107954 0.179934479457646 no 2785 0.177575127184894 4036 977820
SGTC_2877 9040724 71.43 µM -0.925815936179466 0.179623299824436 no 2786 0.177270821950817 3987 6463895
SGTC_1640 st009078 66.4 µM -0.927034603196254 0.179299612863609 no 2787 0.176954284203571 3979 690618
SGTC_3279 9140807 49.47 µM -0.927850677264264 0.179083062749103 no 2788 0.176742516135361 4040 45595718
SGTC_719 2810-4230 27.3 µM -0.931547749588707 0.178104085057666 no 2789 0.175785148379468 3998 721079
SGTC_2080 5212524 12.4 µM -0.932073060918436 0.177965257870999 no 2790 0.175649384493347 3905 260183
SGTC_3341 9147222 25.867 µM -0.933534437658162 0.177579410131716 no 2791 0.175272049156143 4024 1939759
SGTC_1029 k015-0030 64.7 µM -0.933821098246647 0.177503785034452 no 2792 0.175198092198052 4074 2208316
SGTC_142 0335-0849 62.6745 µM -0.934658198511256 0.17728306258278 no 2793 0.174982237938308 4018 3889043 YPR107C YTH1
SGTC_2484 5809818 12.04 µM -0.934941220743198 0.177208475905232 no 2794 0.174909296152343 3984 2870548
SGTC_2214 7179297 48.276 µM -0.935993632288962 0.176931300994288 no 2795 0.174638233135591 4017 769744
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.936861412718444 0.176702958813226 no 2796 0.174414925147366 3998 688667
SGTC_520 3584-0023 682 µM -0.937394408851504 0.176562802031992 no 2797 0.174277857953213 4025 1340790
SGTC_2310 7668677 200 µM -0.938584835155585 0.176250021221817 no 2798 0.173971970891369 4028 2197143
SGTC_329 k048-0121 21.3 µM -0.940181176194041 0.175831138333487 no 2799 0.173562317802402 4035 6832902
SGTC_1975 st070967 30.8 µM -0.940615441249006 0.175717295556759 no 2800 0.173450982983264 3988 261391
SGTC_1769 st044406 64.4 µM -0.942048830168707 0.175341863554368 no 2801 0.173083820253315 3998 670903
SGTC_1419 3993-2473 62.6 µM -0.942360148706098 0.175260390542566 no 2802 0.173004141462282 4083 704026
SGTC_2736 butenafine 14.65 µM -0.943697962341024 0.174910553924555 no 2803 0.172662007794065 3968 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1180 1193-0155 285 µM -0.945735046482551 0.174378710702424 no 2804 0.172141871160812 4100 2921347
SGTC_1949 st076024 69.1 µM -0.947539250206612 0.173908526896661 no 2805 0.171682032757452 3952 2921930
SGTC_129 0088-0017 176.636 µM -0.947723851190478 0.173860464534242 no 2806 0.171635027693457 3865 182446
SGTC_2812 7970281 58.44 µM -0.947921509558774 0.173809011941752 no 2807 0.171584706935364 4089 2233435
SGTC_2552 juarezic acid 87.02 µM -0.949154267898138 0.173488330324583 no 2808 0.171271078522318 4020 1549512
SGTC_1333 1482-0047 286 µM -0.949653798371727 0.173358493044471 no 2809 0.171144096431274 4028 3811116
SGTC_1386 3228-0095 33.8 µM -0.950036323010761 0.173259109595484 no 2810 0.171046898277858 4063 870181
SGTC_3243 9134147 49.47 µM -0.950616945101051 0.173108327931812 no 2811 0.170899431751814 4083 24282180
SGTC_3356 9151811 4.48 µM -0.95064913659282 0.173099970574311 no 2812 0.17089125813043 4020 1859254 YPR165W RHO1
SGTC_3350 9150499 3.57 µM -0.950899583782127 0.173034959789981 no 2813 0.170827676563403 4002 4910996 YPR165W RHO1
SGTC_64 000l-0018 272.079 µM -0.95147974137369 0.172884422927521 no 2814 0.170680448865369 3969 6811119
SGTC_3239 9133757 49.47 µM -0.951687606430592 0.172830507286575 no 2815 0.170627718323664 4038 17036923
SGTC_1548 st061468 90.8 µM -0.951887445268385 0.17277868357534 no 2816 0.170577033681433 4018 390799
SGTC_961 1252-1571 372 µM -0.955551889709919 0.171830148691994 no 2817 0.169649338851072 4053 6813498
SGTC_1311 1190-0148 100 µM -0.957844076809833 0.171238514129543 no 2818 0.169070694733254 4101 1961333
SGTC_944 3370-0224 231 µM -0.958205186374897 0.171145427330322 no 2819 0.16897965124497 4083 4580514
SGTC_2969 9091408 28.7 µM -0.960057424351847 0.170668466376051 no 2820 0.168513157351964 3991 4286311
SGTC_703 3875-0075 71.8 µM -0.96170421976638 0.170245123220882 no 2821 0.168099101038909 4092 2850814
SGTC_1164 k060-0068 93.7 µM -0.966315855616817 0.16906318947236 no 2822 0.166943077225249 4056 5963676
SGTC_1156 4092-0367 4.88 µM -0.96797281469163 0.168639811086395 no 2823 0.166528973413401 4063 1357585
SGTC_2561 acetosyringone 100 µM -0.968860637159804 0.168413239518595 no 2824 0.166307363699987 4046 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_382 3229-0966 23.2 µM -0.969592953132299 0.168226500475744 no 2825 0.166124713426154 4077 5722370
SGTC_2088 5278280 127.392 µM -0.971091390194069 0.167844817451067 no 2826 0.165751385429319 4111 791502
SGTC_640 3381-0960 37.1 µM -0.97172517423054 0.167683547409333 no 2827 0.165593644704906 4105 1745025
SGTC_2338 7999974 200 µM -0.972024497892348 0.167607417464739 no 2828 0.165519180645344 4068 315925
SGTC_2072 5231554 129 µM -0.976159956690875 0.166557884534667 no 2829 0.164492601687559 4095 789545
SGTC_2610 ononetin 44.17 µM -0.976734196926912 0.166412484960165 no 2830 0.164350380307557 4062 259632
SGTC_2719 novobiocin 32.65 µM -0.977793358057951 0.166144516822834 no 2831 0.164088268356325 4068 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1036 k216-0215 33.5 µM -0.977926302259783 0.166110901594188 no 2832 0.164055387650122 4049 622330
SGTC_2045 5106652 78.05 µM -0.978703818678198 0.165914392890136 no 2833 0.163863172359779 4028 673349
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.980120910792933 0.165556625111174 no 2834 0.163513219164511 4032 688803
SGTC_3092 9117248 49.47 µM -0.981660442639417 0.165168511371321 no 2835 0.163133579763825 4156 17141857
SGTC_1241 0364-0022 50.8 µM -0.982014775552383 0.165079267996918 no 2836 0.163046284533613 4094 4563895
SGTC_2697 mebhydrolin 72.4 µM -0.983669503608739 0.164662916492705 no 2837 0.162639019531195 4159 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2988 9073640 71.4286 µM -0.984046622016121 0.164568123787785 no 2838 0.162546295067568 4140 9102229
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.984123460735611 0.1645488138997 no 2839 0.162527406469644 4059 3256 An antibiotic and ribosome inhibitor.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.985327911537174 0.164246322346631 no 2840 0.162231513410553 4015 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_77 0828-0286 12.516 µM -0.985331841304512 0.164245335996554 no 2841 0.162230548573253 3985 745345
SGTC_597 k018-0003 82.8 µM -0.985342156086879 0.164242747060952 no 2842 0.162228016103499 4128 6786234
SGTC_36 0335-0881 14.2 µM -0.985995275379369 0.164078872740406 no 2843 0.162067715655552 3974 23828853
SGTC_486 niguldipine 82 µM -0.987410850664804 0.1637240546012 no 2844 0.161720633577934 4118 1236 A calcium channel blocker.
SGTC_1709 st033179 39.1045 µM -0.988601667390205 0.163425958886344 no 2845 0.161429035048797 4044 573381
SGTC_12 0849-0099 9.267 µM -0.989247758906215 0.163264371191888 no 2846 0.161270968430071 3959 6071388
SGTC_2905 7799065 20.05 µM -0.989378375953081 0.163231716445621 no 2847 0.161239025175636 4000 1296806
SGTC_787 4152-0075 138 µM -0.989940766425823 0.163091165219225 no 2848 0.161101536049258 4087 9566539
SGTC_3118 9124250 49.47 µM -0.991129992394277 0.162794215936196 no 2849 0.160811054742837 4019 1504786
SGTC_1122 capsaicin 818.572 nM -0.992381064441708 0.162482203480014 no 2850 0.160505836200483 4149 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_23 0213-0011 39.996 µM -0.99399566751072 0.16208010339682 no 2851 0.160112488353228 4085 627608
SGTC_2883 9059145 45.46 µM -0.996514529460577 0.161454102313201 no 2852 0.159500105551457 4074 16476510
SGTC_956 1185-0240 191 µM -0.998182871780043 0.161040346029253 no 2853 0.159095345251382 4071 1416193
SGTC_1424 4048-1941 275 µM -1.00245122718885 0.159984927743373 no 2854 0.158062855654213 4164 X1424
SGTC_191 3914-0123 66.505 µM -1.00407082979236 0.159585641942132 no 2855 0.157672237219381 4070 3144412
SGTC_1162 k048-0130 20.1 µM -1.00693972493444 0.158879966314817 no 2856 0.156981870243097 4053 6797406
SGTC_2786 7743617 45.45 µM -1.00876652973943 0.158431685910325 no 2857 0.156543308232347 4058 583674
SGTC_533 1222-0222 6.71 µM -1.00920024382126 0.158325378620403 no 2858 0.156439304867917 4149 3982874
SGTC_419 nsc-638432 893 µM -1.01232656517544 0.157560473511608 no 2859 0.155690968585919 4062 368090
SGTC_2403 6032726 181.2 µM -1.0125722897197 0.157500456125186 no 2860 0.155632250621659 4171 2881040
SGTC_883 0850-0245 24.6 µM -1.01451334454403 0.157026888210829 no 2861 0.155168932559212 4173 6823229 YPR165W RHO1
SGTC_3078 9116413 49.47 µM -1.01579232998336 0.156715360778681 no 2862 0.154864144622756 4037 17177322
SGTC_359 0081-0058 15.9 µM -1.01701601190824 0.156417684872068 no 2863 0.154572906182639 4217 3494159
SGTC_568 1193-0097 7.48 µM -1.01770755767006 0.156249622519326 no 2864 0.154408477276798 3955 3646150
SGTC_1853 st056710 91.2 µM -1.01776392264486 0.156235929711559 no 2865 0.154395080469733 4180 269167
SGTC_386 1509-0011 3.07 µM -1.01823222682267 0.156122194611828 no 2866 0.154283803817339 4110 3107280
SGTC_423 5-fluorouracil 457 µM -1.02021479222896 0.155641301674269 no 2867 0.153813301851714 4050 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_448 monastrol 171 µM -1.02275009131272 0.155027762126898 no 2868 0.153213010466214 4024 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.02454216499192 0.154595047026214 no 2869 0.15278963285291 4078 688761
SGTC_226 1,3-diallylurea 8.28947 mM -1.02636671316729 0.154155311449243 no 2870 0.152359381004653 4062 74537 YKL182W FAS1
SGTC_1033 k072-0102 21.3 µM -1.02762324564509 0.153852955273396 no 2871 0.152063542613019 4099 5965931
SGTC_1912 st060209 90.8 µM -1.02822760330396 0.153707670128824 no 2872 0.151921388424714 4128 688787
SGTC_2117 5521686 200 µM -1.02827501636084 0.15369627606466 no 2873 0.151910239882559 4072 803312
SGTC_2314 7727897 200 µM -1.02852110672205 0.15363714586681 no 2874 0.15185238377806 4137 900724
SGTC_2972 9093619 59.92 µM -1.03315012110509 0.152527700272791 no 2875 0.15076682543074 4086 25236256
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.03466991590466 0.152164609940769 no 2876 0.15041154510967 4228 688801
SGTC_2731 amoxapine 43.43 µM -1.03514691130732 0.152050770604181 no 2877 0.150300153655894 4238 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1513 0337-0559 19 µM -1.03518489491541 0.152041707899122 no 2878 0.150291285809733 4096 775073
SGTC_2683 piperine 63.03 µM -1.03556905935884 0.151950068285838 no 2879 0.150201616423173 4104 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_930 2810-3379 265 µM -1.03812183195836 0.151342055200901 no 2880 0.149606669266381 4170 1015764
SGTC_2534 helenine 20.12 µM -1.03976021875415 0.150952681911186 no 2881 0.149225657741311 4130 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_909 3448-9333 149 µM -1.04125982437803 0.150596875796571 no 2882 0.148877488614897 4056 3344074
SGTC_2657 nystatin 74.44 µM -1.04201407287693 0.150418129215054 no 2883 0.1487025772096 4154 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_953 1188-0045 9.7 µM -1.04278882737979 0.150234670214636 no 2884 0.148523053500019 4153 6144426
SGTC_1020 4335-0961 93.3 µM -1.04808010645753 0.148985703308529 no 2885 0.147300850496221 4076 669075
SGTC_2265 7929201 200 µM -1.04889809697425 0.148793243619729 no 2886 0.147112510745855 4099 1265108
SGTC_1451 4152-0210 104 µM -1.04895949357112 0.148778804718995 no 2887 0.147098380889 4178 659563
SGTC_1880 MG-132 525 µM -1.0511153236315 0.148272402638644 no 2888 0.146602813516059 4107 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_219 mitoxanthrone 164.414 µM -1.05360896196953 0.147688089658285 no 2889 0.146030992200184 4094 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2569 tetrandrine 100 µM -1.05491418661025 0.147382863191192 no 2890 0.14573228668631 4168 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3285 9112818 20.8695 µM -1.05533471869877 0.147284611966464 no 2891 0.145636133900112 4116 17017947 YPR165W RHO1
SGTC_2272 7805186 180 µM -1.05535886526434 0.147278971804565 no 2892 0.145630614190796 4158 2956062 YPR165W RHO1
SGTC_1979 st071809 45.3 µM -1.05855082715076 0.146534666708724 no 2893 0.144902195679464 4247 4976333
SGTC_1458 k015-0034 6.33 µM -1.05885607317855 0.146463621609306 no 2894 0.14483266604412 4178 3598957
SGTC_1613 st002381 52.1 µM -1.06122529381364 0.145912978900246 no 2895 0.144293763522308 4141 551167
SGTC_2957 9076800 11.52 µM -1.06125238860608 0.145906689716996 no 2896 0.144287608372637 4123 16459615
SGTC_2284 7945075 39.21 µM -1.06246068717906 0.145626407322175 no 2897 0.144013297967116 4152 1245402
SGTC_2172 5754775 163.918 µM -1.06262028305607 0.145589413825061 no 2898 0.143977092498395 4123 2263357
SGTC_2556 citropten 84.59 µM -1.06383397600024 0.145308292847429 no 2899 0.143701958424325 4184 2775 A potential DNA crosslinker.
SGTC_2343 7990716 14.84 µM -1.0642081104399 0.145221707845405 no 2900 0.143617216854138 4148 6456862
SGTC_1232 0279-0259 161 µM -1.06626319484891 0.144746723927748 no 2901 0.143152341091064 4159 1560000
SGTC_2851 9015922 71.43 µM -1.06877067333961 0.144168598482838 no 2902 0.142586508509086 4184 2996893
SGTC_1510 1123-0200 71.5 µM -1.06942759280889 0.144017396524621 no 2903 0.142438519733718 4213 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2455 5377712 9.75 µM -1.06985161354522 0.143919857257551 no 2904 0.142343052853055 4157 2243908
SGTC_2998 9066762 71.4286 µM -1.07301673991748 0.14319317787004 no 2905 0.141631802705532 4235 4945196
SGTC_2087 5276107 200 µM -1.07571604612956 0.142575407170624 no 2906 0.141027134431131 4137 144405
SGTC_460 trequinsin 123 µM -1.07670928927183 0.142348545072765 no 2907 0.140805080538818 4230 5537 A vasodilator.
SGTC_2471 5466956 24.79 µM -1.07891579977042 0.141845440433631 no 2908 0.140312632403653 4146 724419
SGTC_1616 st002734 56.1 µM -1.0800640148582 0.141584113748487 no 2909 0.140056837449321 4117 4026101
SGTC_1394 3474-0001 65.7 µM -1.08198878526963 0.141146779949764 no 2910 0.139628755594521 4180 5017666 YIL048W NEO1
SGTC_1125 tnp00248 1.32998 µM -1.0835072591379 0.140802409211052 no 2911 0.139291665270249 4255 24207736
SGTC_1909 st060837 51.5 µM -1.08369512352912 0.140759843595527 no 2912 0.13924999924413 4146 678937
SGTC_1719 st032227 49.2 µM -1.08400941179949 0.14068865285163 no 2913 0.139180312910684 4181 3125804
SGTC_2623 humulene 100 µM -1.08424667024151 0.140634926642899 no 2914 0.139127721927526 4197 6187145 An anti-inflammatory.
SGTC_1360 1598-0022 39.8 µM -1.08426488096402 0.140630803474394 no 2915 0.13912368587651 4205 761525
SGTC_587 k089-0003 57 µM -1.08426793140255 0.140630112819427 no 2916 0.139123009814173 4047 9659696
SGTC_2386 9075165 157.42 µM -1.0853073163635 0.140394917928259 no 2917 0.138892783266555 4153 16452277
SGTC_1267 0828-0272 9.49 µM -1.08627313155754 0.140176610137078 no 2918 0.138679085272847 4263 745334
SGTC_306 1672-3436 11.6 µM -1.08654123016983 0.140116051446378 no 2919 0.138619805031329 4222 6797378
SGTC_3143 9086658 49.47 µM -1.08821441642659 0.139738510169141 no 2920 0.138250230936133 4222 25236626
SGTC_642 0335-0876 158 µM -1.0891488069401 0.139527973548322 no 2921 0.138044134930445 4215 6812350
SGTC_637 1181-0519 7.26 µM -1.09135111949868 0.13903260289426 no 2922 0.137559206039285 4176 6252091 YGR060W ERG25
SGTC_2931 9014674 55.67 µM -1.09610898317088 0.13796649820051 no 2923 0.136515541935066 4146 2996810
SGTC_3275 9138069 49.47 µM -1.10114548799466 0.136844048052348 no 2924 0.135416671100725 4276 17617007
SGTC_2580 diallyl disulphide 81.36 µM -1.10135406207615 0.136797699609934 no 2925 0.135371295241944 4173 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.10226390712914 0.136595643236326 no 2926 0.135173477864591 4204 521171
SGTC_1408 3909-7976 48.8 µM -1.10571620823654 0.135830820796052 no 2927 0.134424686174809 4243 24152374
SGTC_3303 9125618 40.5795 µM -1.10809810154354 0.135304849194789 no 2928 0.133909725389451 4206 22695467
SGTC_2145 5634607 200 µM -1.10842910660725 0.135231867026538 no 2929 0.1338382701642 4165 308662
SGTC_14 0354-0009 295 µM -1.10975324033573 0.134940183284094 no 2930 0.133552686907757 4280 1713507
SGTC_759 3486-0358 89.3 µM -1.11133783003948 0.134591693198889 no 2931 0.133211480843372 4198 875103
SGTC_163 TUB2.036 7.546 µM -1.11208702754573 0.134427141583784 no 2932 0.133050366897633 4181 15992207 YJR013W GPI14
SGTC_1476 4112-3294 3.34 µM -1.11323184431916 0.134175964166138 no 2933 0.132804434707128 4206 704369
SGTC_3116 9124943 49.47 µM -1.11432439179667 0.133936555660313 no 2934 0.132570023231414 4192 41905195 YPL160W CDC60
SGTC_550 4123-0385 25.7 µM -1.11890505574513 0.132935997253892 no 2935 0.131590322944282 4240 5731123
SGTC_421 streptovitacin 30 mM -1.11952706609563 0.132800528871148 no 2936 0.131457675354768 4261 91467 include heat shock
SGTC_1196 1588-0294 184 µM -1.12048391188027 0.132592321936309 no 2937 0.131253802291212 4237 6144269
SGTC_1431 4049-0260 9.09 µM -1.120507558717 0.132587179300611 no 2938 0.131248766677173 4207 3854841
SGTC_363 0455-0021 3.06 µM -1.12090560588706 0.132500633944927 no 2939 0.131164022218251 4172 4597466
SGTC_2665 lovastatin 100 µM -1.12265224360772 0.132121331648194 no 2940 0.130792608925947 4222 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_420 mitomycin C 81.9 mM -1.12792324821343 0.130981214546858 no 2941 0.12967616731865 4206 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3266 9136860 49.47 µM -1.12840396483162 0.130877574939254 no 2942 0.129574677056649 4046 4871271 YPR165W RHO1
SGTC_530 4358-1714 28 µM -1.13011229803378 0.130509727215936 no 2943 0.12921445416796 4223 1564641
SGTC_1427 4048-4900 550 nM -1.13116066838985 0.130284340674655 no 2944 0.128993736525966 4213 24132586
SGTC_3013 9080133 71.4286 µM -1.13148917660469 0.130213770952854 no 2945 0.128924628196021 4312 17050193
SGTC_1075 aripiprazole 15.2 µM -1.13159429123397 0.130191195946782 no 2946 0.12890252063713 4286 60795 An atypical antipschotic. YIL048W NEO1
SGTC_470 aa-861 153 µM -1.13196688048366 0.13011119840767 no 2947 0.128824179375963 4187 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_661 1304-0007 33.6 µM -1.13282229779838 0.129927663004478 no 2948 0.128644442827357 4222 3117130
SGTC_1361 1608-0041 5.61 µM -1.13365148338771 0.129749926935481 no 2949 0.128470384135608 4193 X1361
SGTC_1955 wogonin 32.4 µM -1.13381395227255 0.129715121439986 no 2950 0.12843629860285 4292 5281703 A flavanone.
SGTC_174 3553-0389 74.3 µM -1.13398822504971 0.129677794400626 no 2951 0.128399743624473 4306 738071
SGTC_2726 cimetidine 79.27 µM -1.13444283372895 0.129580457950806 no 2952 0.128304420156025 4211 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3022 9087993 49.47 µM -1.13491050338337 0.129480377835755 no 2953 0.128206409316655 4296 17173644
SGTC_1133 3473-0247 50 µM -1.13526000256131 0.129405620876513 no 2954 0.128133197750792 4212 711311
SGTC_3296 9122258 64.045 µM -1.13663199037386 0.12911244545799 no 2955 0.127846080474241 4205 4730474
SGTC_698 k064-0052 127 µM -1.13926572133104 0.128550943688914 no 2956 0.127296170551735 4318 5088751
SGTC_792 4534-1957 155 µM -1.14393590574605 0.127559449411126 no 2957 0.126325109469509 4195 1717904
SGTC_1516 st013856 110 µM -1.14458606938953 0.127421840477752 no 2958 0.126190332820194 4292 5281404 A mutagen and neurotoxin.
SGTC_2870 9038528 12.99 µM -1.14553511398695 0.127221157959812 no 2959 0.125993779176337 4277 6463316
SGTC_2729 fluphenazine 10.66 µM -1.14723042600362 0.126863219121161 no 2960 0.125643199900473 4163 3372 An atypical antipsychotic.
SGTC_2927 9011802 47.9 µM -1.14730334825101 0.126847838462238 no 2961 0.125628135346264 4247 43912568
SGTC_2761 levamisole 97.89 µM -1.1511796305445 0.126032126415839 no 2962 0.124829171681671 4264 26879 An alkaline phosphatase inhibitor.
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.15308669834843 0.125632154512922 no 2963 0.124437400377287 4296 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3102 9121669 49.47 µM -1.15553025391001 0.125120959900889 no 2964 0.123936675413713 4275 41905072
SGTC_1782 st039423 80.636 µM -1.15992932656853 0.124204334271602 no 2965 0.123038790729643 4287 2068169
SGTC_3325 9138760 55.175 µM -1.16219456241605 0.123734168429794 no 2966 0.122578221453499 4191 43844959
SGTC_2059 5238311 157 µM -1.16255491425097 0.123659489869113 no 2967 0.122505066135411 4211 703021
SGTC_2419 paclitaxel 166.5 µM -1.16308447735992 0.123549801596261 no 2968 0.12239761469888 4176 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_850 0388-0143 75.9 µM -1.16476363563048 0.123202448625616 no 2969 0.122057341159672 4231 67273
SGTC_327 1273-0057 3.96 µM -1.16620809777 0.122904193266484 no 2970 0.121765159668389 4141 3108138
SGTC_2872 9044037 25.97 µM -1.17020411897296 0.122081725829346 no 2971 0.120959417823556 4286 6465195
SGTC_469 w7 172 µM -1.17020726805256 0.122081079208538 no 2972 0.120958784338581 4341 45115570 A P450 inhibitor.
SGTC_908 3448-7491 47.7 µM -1.17021450049922 0.122079594132761 no 2973 0.120957329431418 4254 1203031
SGTC_1024 4507-0395 26 µM -1.17031296919437 0.122059376307079 no 2974 0.120937522309927 4299 4201836
SGTC_3104 9120930 49.47 µM -1.1709362502237 0.121931457315199 no 2975 0.120812201366792 4277 17014836
SGTC_1546 5-methoxyflavanone 78.7 µM -1.17294222307839 0.121520401088817 no 2976 0.120409487952343 4271 147795
SGTC_639 0833-0042 114 µM -1.17459168001741 0.121183131275306 no 2977 0.120079056752997 4268 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2624 nerol 100 µM -1.17537192446783 0.121023821747881 no 2978 0.119922975359059 4174 637566 A natural product oil.
SGTC_772 k072-0172 35.3 µM -1.17623449936354 0.120847873626421 no 2979 0.11975059095976 4309 5861980
SGTC_1590 st077108 57.8 µM -1.17947290096849 0.120188911068847 no 2980 0.119104960612717 4284 5489485
SGTC_2372 9071633 200 µM -1.1800717916764 0.120067324389266 no 2981 0.118985831343201 4305 21321366
SGTC_1668 st014914 51.6 µM -1.18049407029551 0.119981645589769 no 2982 0.118901883734177 4274 2839556
SGTC_596 1155-0152 116 µM -1.18087567784611 0.119904255879893 no 2983 0.118826057387835 4269 280313
SGTC_781 4335-2806 94.4 µM -1.18102322111081 0.119874343657545 no 2984 0.11879674934087 4326 845254
SGTC_2735 sertaconazole 140 nM -1.18121806185801 0.119834850629126 no 2985 0.118758053929395 4399 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2826 7992541 19.48 µM -1.18127669287622 0.119822968275931 no 2986 0.118746411540403 4284 2985066
SGTC_2792 7535235 81.82 µM -1.18273990693399 0.119526697573676 no 2987 0.11845612154825 4262 1281891
SGTC_913 3487-1245 167 µM -1.18334437925362 0.119404455346807 no 2988 0.118336345588559 4222 4016153
SGTC_3005 9076496 71.4286 µM -1.18569163516059 0.11893060704814 no 2989 0.117872049565135 4235 21368410
SGTC_1957 st077035 62.4 µM -1.18706189673426 0.118654602498748 no 2990 0.117601603276969 4273 705593
SGTC_2041 5107442 45.335 µM -1.18707449829467 0.118652066334911 no 2991 0.117599118167619 4303 793005
SGTC_2897 9048598 12.99 µM -1.18748281550461 0.118569909988607 no 2992 0.117518615484646 4243 6467404
SGTC_1588 farnesol 29.9 µM -1.18806959818197 0.11845191551921 no 2993 0.117402995382023 4286 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2730 imipramine 71.33 µM -1.18857177551271 0.118351000027105 no 2994 0.11730410996762 4243 3696 A tricyclic antidepressant.
SGTC_841 0251-0215 91.2 µM -1.19178261730003 0.117707199037208 no 2995 0.116673246675024 4308 3888614
SGTC_714 4296-0578 26.1 µM -1.19606074755471 0.11685325473131 no 2996 0.115836426974185 4334 1589775
SGTC_3109 9122853 49.47 µM -1.19815119912637 0.116437587122285 no 2997 0.115429079903916 4305 1234709
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.19834363157159 0.116399376436425 no 2998 0.115391633593252 4323 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1496 4469-0713 57.4 µM -1.20114755786839 0.115843618799359 no 2999 0.11484698389773 4263 746691
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.20277898693961 0.115521126689432 no 3000 0.114530929196894 4285 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_709 3807-1509 243 µM -1.20597474313537 0.114891256552612 no 3001 0.113913614546717 4355 1886677 YPL242C IQG1
SGTC_2889 9059656 51.95 µM -1.20868309498261 0.114359367327441 no 3002 0.113392309380659 4362 3949838
SGTC_1487 3970-0795 2.82 µM -1.21000015635714 0.11410134612903 no 3003 0.113139416445276 4349 3765103
SGTC_1956 st077085 54 µM -1.21005357567968 0.114090889681518 no 3004 0.11312916773896 4328 24208685
SGTC_1881 5652484 16 µM -1.2102985073134 0.114042954818762 no 3005 0.113082185127336 4273 2255129
SGTC_1339 1486-1321 22.7 µM -1.2138286893955 0.113353666193671 no 3006 0.112406574201346 4323 3469382
SGTC_2232 chlorophetanol 41.5365 µM -1.21442377008053 0.11323776651691 no 3007 0.112292971506941 4356 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3193 9111931 49.47 µM -1.21493208326583 0.113138832905357 no 3008 0.112195997981927 4306 17087244
SGTC_1722 st034304 3.6505 µM -1.21546254436783 0.113035654399001 no 3009 0.112094863023319 4256 4036148 YLR033W RSC58
SGTC_276 colchicine 750 µM -1.21780139897649 0.112581531112997 no 3010 0.111649726288586 4362 2833 A microtubule depolymerizer.
SGTC_3206 9114350 49.47 µM -1.21820921000929 0.112502482159306 no 3011 0.11157224031597 4163 17087243
SGTC_3322 9139058 2.11 µM -1.21830398051463 0.112484117787697 no 3012 0.111554238995101 4351 4908926 YPR165W RHO1
SGTC_3154 9100113 49.47 µM -1.21871909286865 0.11240370367422 no 3013 0.111475414365697 4302 25237525
SGTC_195 4234-0266 16.654 µM -1.2192459339392 0.112301705018642 no 3014 0.111375431261111 4317 2303354
SGTC_3093 9117344 49.47 µM -1.22276546458527 0.111622005588848 no 3015 0.110709146477715 4319 24824913
SGTC_1054 3429-0080 167 µM -1.22457367619525 0.111273946582203 no 3016 0.110367945561522 4326 1162877
SGTC_1282 0886-0010 32.4 µM -1.22552719537361 0.111090718800411 no 3017 0.110188324981188 4329 2836211 YNL267W PIK1
SGTC_1696 st025591 34.7925 µM -1.22554169568174 0.111087934097079 no 3018 0.110185595083782 4312 2787147
SGTC_980 1473-0395 201 µM -1.22628750778382 0.110944772442875 no 3019 0.110045250337705 4196 768876
SGTC_2733 amorolfine 100 µM -1.23101419914513 0.110040537216748 no 3020 0.109158776850988 4468 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1896 st058441 89 µM -1.23389609528213 0.109491820195008 no 3021 0.108620812369294 4314 688759
SGTC_756 0508-1999 28.3 µM -1.23398603885886 0.109474726491025 no 3022 0.108604053313828 4331 6753853
SGTC_1046 2001-0062 216 µM -1.2340229658931 0.109467709093033 no 3023 0.108597173291971 4241 739778
SGTC_1710 st031758 61.5 µM -1.23403660972204 0.109465116381172 no 3024 0.108594631335534 4351 5394341
SGTC_2940 9060638 45.86 µM -1.24179157350599 0.107998583494597 no 3025 0.107156736278176 4305 4027022
SGTC_2404 5161160 200 µM -1.24541629655057 0.107317988858645 no 3026 0.106489383001914 4267 2831543
SGTC_2283 7944793 200 µM -1.252242008812 0.106044766197216 no 3027 0.105240846429923 4341 2970533
SGTC_348 k064-0012 10.7 µM -1.25668975772852 0.105221007535165 no 3028 0.104432999175388 4256 5066323
SGTC_721 1187-1332 279 µM -1.2587008289533 0.104850064998509 no 3029 0.104069205949264 4292 25730
SGTC_2540 epiandrosterone 100 µM -1.25935198356094 0.104730162546805 no 3030 0.10395161232273 4368 441302 A steroid.
SGTC_3273 9137859 49.47 µM -1.26185898911956 0.104269454158243 no 3031 0.103499765678145 4431 2377234
SGTC_2195 6536160 144.242 µM -1.26308948150184 0.10404386672731 no 3032 0.10327851185004 4312 3834386
SGTC_347 4534-1311 26.2 µM -1.26325528920482 0.104013496107082 no 3033 0.103248724377188 4338 2862016
SGTC_1198 1612-1005 86.7 µM -1.26514125742991 0.103668499909036 no 3034 0.102910347757836 4408 6998509
SGTC_3145 9085516 49.47 µM -1.26579792731707 0.103548571753928 no 3035 0.10279271867942 4328 25236195
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.26931314220219 0.102908297029924 no 3036 0.10216470044708 4347 115019
SGTC_5 0352-0601 109.883 µM -1.26940357200331 0.102891863833316 no 3037 0.102148581425824 4240 762456
SGTC_1193 1488-0126 41.5 µM -1.27124688917644 0.102557305694076 no 3038 0.10182041512424 4309 1384710
SGTC_2659 sanguinarine 24.21 µM -1.27734115025252 0.101456840782783 no 3039 0.100740915817287 4298 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3323 9138564 53.9225 µM -1.27866650390453 0.101218659275088 no 3040 0.100507259984617 4353 43912313 YNL103W MET4
SGTC_2421 5690543 90.72 µM -1.27881539826151 0.101191926702077 no 3041 0.100481035085739 4360 3397993
SGTC_1252 0493-0875 34.8 µM -1.27897827706127 0.101162689247531 no 3042 0.1004523528126 4329 3960963
SGTC_1603 st002045 67.8 µM -1.27983041227998 0.101009827611629 no 3043 0.100302392756027 4353 5887985
SGTC_132 0417-1715 25.805 µM -1.2821292117846 0.100598293717055 no 3044 0.0998986615682788 4336 6769098
SGTC_1523 st012844 44.7 µM -1.28567618255992 0.099965712336903 no 3045 0.099278048410024 4411 4274103
SGTC_1850 st056238 17 µM -1.28646061946114 0.0998262057386038 no 3046 0.0991411770297646 4376 5393177
SGTC_1105 epirubicin 18.1 µM -1.28774045743581 0.0995989009130764 no 3047 0.0989181626215542 4377 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2517 totarol 10 µM -1.28895462523203 0.0993836092212288 no 3048 0.0987069308459034 4350 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2120 5538279 151.968 µM -1.28998513247019 0.0992011505959849 no 3049 0.0985279101110817 4315 2058197
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.29723172988562 0.0979250027779715 no 3050 0.0972757331688494 4360 688662
SGTC_2092 5303694 80.6725 µM -1.29776388094066 0.0978317657683416 no 3051 0.0971842423538781 4360 1963699
SGTC_2445 5742597 35.57 µM -1.29810840107989 0.0977714378676015 no 3052 0.0971250439307502 4362 1774255
SGTC_1631 benzylvanillin 81.9 µM -1.29845497911321 0.0977107771360711 no 3053 0.0970655186091903 4416 75506
SGTC_578 3460-0051 92 µM -1.30006399450114 0.0974295163845192 no 3054 0.09678951839422 4420 2876744
SGTC_541 4513-1321 94 µM -1.30251865171036 0.0970015796518104 no 3055 0.0963695730844741 4337 747515
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.30720074012469 0.0961891488581392 no 3056 0.0955722721214614 4334 6857784
SGTC_3056 9094900 49.47 µM -1.30843467625822 0.0959758728402338 no 3057 0.0953629587779594 4353 25236784
SGTC_2003 4023581 200 µM -1.31259910404645 0.0952586521352144 no 3058 0.0946590358414888 4395 16641307
SGTC_1581 himbacine 57.9 µM -1.31460268213096 0.0949149942982057 no 3059 0.0943217341225064 4376 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_752 1896-0090 130 µM -1.31621254037991 0.0946395305813776 no 3060 0.0940513579113635 4371 772567
SGTC_1401 3807-4679 7.6 µM -1.31675010947593 0.0945476782089096 no 3061 0.0939612004927045 4287 3291456
SGTC_1842 st055362 61.2 µM -1.32220554942067 0.0936192433486558 no 3062 0.0930498568332426 4333 676032
SGTC_313 3474-0040 5.03 µM -1.32373896089077 0.0933594955770205 no 3063 0.0927948771170594 4385 1043375 YIL048W NEO1
SGTC_1356 1502-0781 85.8 µM -1.32858393625317 0.092542293947585 no 3064 0.0919926373262795 4386 567702
SGTC_1960 st011366 51.8 µM -1.32915382567814 0.0924465196607581 no 3065 0.0918986126203768 4414 3972846
SGTC_914 3820-6779 408 µM -1.33064104085362 0.0921969272106518 no 3066 0.0916535757754857 4325 2893481
SGTC_839 0122-0028 230 µM -1.33292161456837 0.0918151585349067 no 3067 0.0912787642872259 4419 759448
SGTC_1802 st050112 57.9 µM -1.34778923385101 0.0893549748794547 no 3068 0.0888630908188671 4407 4662563
SGTC_317 4495-0002 170 µM -1.34907794743492 0.089144060046848 no 3069 0.0886559653525229 4425 15991618
SGTC_742 0kpi-0133 140 µM -1.34922865400721 0.0891194191618295 no 3070 0.0886317668955524 4431 2728852
SGTC_2768 sulfasalazine 50.2 µM -1.35275804292587 0.0885438041067638 no 3071 0.0880664703768374 4387 5384001 An antioxidant and salicylic acid derivative.
SGTC_15 0266-0086 27.098 µM -1.35315636188669 0.0884790158004951 no 3072 0.0880028414640942 4473 1712902 YIL048W NEO1
SGTC_3057 9095946 49.47 µM -1.35684424879241 0.0878808415119195 no 3073 0.0874153522155171 4467 24540043
SGTC_2304 7443016 91.4 µM -1.35749669545517 0.0877753295730217 no 3074 0.0873117213692415 4352 939854
SGTC_1848 st056003 16.4 µM -1.35867829464712 0.087584485076929 no 3075 0.0871242765056793 4411 146492
SGTC_18 0111-0177 500 nM -1.35923456270362 0.0874947474140658 no 3076 0.0870361361509281 4487 721752
SGTC_2427 5545055 42.75 µM -1.36176075596907 0.0870880829095093 no 3077 0.0866367001465864 4324 5372858
SGTC_1627 st003713 25.6 µM -1.36593909477743 0.0864185582820865 no 3078 0.0859790403210053 4414 16195070 YER133W GLC7
SGTC_215 1287-0124 461.5 µM -1.36596177457209 0.0864149346705462 no 3079 0.0859754808013874 4429 5560863
SGTC_3055 9094636 49.47 µM -1.36762631821419 0.0861492961193474 no 3080 0.0857145370530701 4443 25236176
SGTC_1013 4112-3890 241 µM -1.36836236282198 0.0860320283635253 no 3081 0.08559933956375 4373 705171
SGTC_3355 9151058 44.0485 µM -1.36958254680431 0.0858378899527791 no 3082 0.0854086254230228 4431 17015728
SGTC_95 0471-0001 561.058 µM -1.37558962677567 0.0848869068613224 no 3083 0.0844743600147687 4413 4015405
SGTC_2009 4012297 12.05 µM -1.37578430218586 0.0848562203964465 no 3084 0.0844442114365659 4386 45595307
SGTC_2316 5844804 197.44 µM -1.37684012189721 0.0846899375865896 no 3085 0.0842808415982056 4424 776813
SGTC_1839 st053978 48 µM -1.3784892925564 0.0844306960775422 no 3086 0.0840261357467788 4456 3788398
SGTC_509 pifithrin 175 µM -1.37933775954691 0.0842975534218856 no 3087 0.0838953197909242 4498 4817 A p53 inhibitor.
SGTC_582 0987-0078 156 µM -1.37980686155066 0.0842240089364015 no 3088 0.0838230597109932 4481 1625765
SGTC_2622 2-methoxyxanthone 59.94 µM -1.38171008769494 0.0839261205296471 no 3089 0.0835303678704208 4397 71034 A hepatoprotective.
SGTC_484 loperamide 105 µM -1.38284599561167 0.0837487083565018 no 3090 0.0833560461150641 4502 3955 An opioid-receptor agonist.
SGTC_3317 9138495 8.753 µM -1.38398899233037 0.0835704735277833 no 3091 0.0831809126521934 4337 17020139
SGTC_362 0310-0100 9.03 µM -1.38536083093025 0.0833569304338413 no 3092 0.0829710808230962 4463 790235
SGTC_2715 st079500 56.4 µM -1.38541707999069 0.0833481833563884 no 3093 0.082962485660763 4415 28246688
SGTC_3335 9143315 29.6265 µM -1.38727490937926 0.0830596669666442 no 3094 0.0826789754666071 4435 4899691
SGTC_2156 5649887 115 µM -1.38909395368213 0.0827779022049433 no 3095 0.0824020910583235 4451 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2240 6690706 185.951 µM -1.39970638425162 0.0811483884403688 no 3096 0.0808006306118777 4327 805876
SGTC_878 0828-0289 13.7 µM -1.40535756090582 0.0802905995515425 no 3097 0.0799574899131752 4392 745350 YLR208W SEC13
SGTC_1670 st016595 4.04 µM -1.40832143839871 0.0798434624512949 no 3098 0.0795179551591882 4465 597879
SGTC_311 1315-0136 58 µM -1.41173630159199 0.0793306264824177 no 3099 0.0790138101463865 4459 6759207
SGTC_2865 9030313 51.95 µM -1.41478402782373 0.0788750354815693 no 3100 0.0785659142640119 4428 42562754
SGTC_1177 0983-0204 23.6 µM -1.41518892512192 0.0788146586507707 no 3101 0.0785065553941731 4466 766818
SGTC_1150 3909-7983 10.9 µM -1.41561330323374 0.0787514145019296 no 3102 0.0784443770889475 4446 23965914
SGTC_2253 7938677 135.83 µM -1.41980862969985 0.078128261814788 no 3103 0.0778317009629404 4501 2301972
SGTC_121 0557-0495 61.343 µM -1.42065879200329 0.0780024400135989 no 3104 0.0777079888895038 4490 3104427
SGTC_691 1548-0686 185 µM -1.42256560193952 0.0777207963029447 no 3105 0.0774310607809923 4421 46495133
SGTC_1412 3909-8563 178 µM -1.42524738532666 0.0773259930174277 no 3106 0.0770428516396197 4536 23767530
SGTC_903 1134-0042 114 µM -1.42772994952564 0.0769618777218802 no 3107 0.0766848011425941 4448 701009
SGTC_1925 st057770 10.1 µM -1.42878429624621 0.0768076325660449 no 3108 0.0765331202470991 4444 5989122
SGTC_681 1642-0006 26.6 µM -1.43058078206127 0.0765453581030214 no 3109 0.0762751992728988 4468 4446530
SGTC_2497 7-hydroxyflavone 100 µM -1.43477775912354 0.0759352839686855 no 3110 0.0756752188110042 4466 5281894
SGTC_2916 7875993 68.79 µM -1.4406810978244 0.0750834482378765 no 3111 0.0748373986999476 4351 1299250
SGTC_499 genistein 192 µM -1.44877268811605 0.0739277185317137 no 3112 0.0737005367152097 4559 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_224 benfluorex 43.875 µM -1.44960166482648 0.0738100868827763 no 3113 0.0735848157497389 4471 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3175 9106517 49.47 µM -1.45342304684437 0.0732696823782284 no 3114 0.0730531656840377 4484 41468073
SGTC_201 4262-0159 12.803 µM -1.45349028169815 0.0732602014643027 no 3115 0.0730438380154513 4520 1341029
SGTC_795 0685-0265 78 µM -1.45687292471127 0.0727844189836833 no 3116 0.0725757305531301 4469 302754
SGTC_2203 7227154 166.4 µM -1.4611977730984 0.0721795619811677 no 3117 0.0719805870039445 4503 896304
SGTC_2597 laccaic acid a 100 µM -1.46306616821683 0.0719194500918503 no 3118 0.0717246370844388 4455 5491415 A textile dye.
SGTC_2334 9017922 200 µM -1.46501006452365 0.0716495907378865 no 3119 0.0714590859318573 4497 3163164
SGTC_17 0960-0276 49.807 µM -1.4661399602658 0.071493091537262 no 3120 0.0713050806170973 4477 6821114
SGTC_1439 4092-1168 46 µM -1.46691128017484 0.0713864085779981 no 3121 0.0712000957714204 4484 2886240
SGTC_3221 9128209 49.47 µM -1.46742676012017 0.0713151795526602 no 3122 0.0711299996535885 4494 16460723
SGTC_397 arbidol 50 µM -1.46986529868854 0.0709789615571505 no 3123 0.0707991197881965 4494 131410 A RNA synthesis inhibitor.
SGTC_1512 0259-0544 12.2 µM -1.47525516016065 0.0702401452485586 no 3124 0.0700719783354219 4445 18476
SGTC_3172 9105863 49.47 µM -1.47566681740555 0.0701839612747821 no 3125 0.0700166790501629 4576 2348785
SGTC_2465 5809242 33.21 µM -1.47634041061985 0.0700921022115028 no 3126 0.0699262654641474 4555 2731748
SGTC_2495 cafestol 54.53 µM -1.48396205808297 0.0690591586707463 no 3127 0.0689094933049961 4475 16667697 An anti-infammatory.
SGTC_2202 7226349 200 µM -1.48480085503552 0.0689461988994204 no 3128 0.0687982926787286 4480 844334
SGTC_764 1951-2361 146 µM -1.48740595611311 0.068596281040442 no 3129 0.0684538123812029 4490 5438930
SGTC_2704 st078022 71.1 µM -1.49334967737352 0.0678030478418378 no 3130 0.0676728391008767 4510 54697681
SGTC_1743 st037606 46.3785 µM -1.49376162011108 0.0677483346893235 no 3131 0.06761896813907 4449 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.49954046399874 0.0669843939844609 no 3132 0.0668667397824782 4542 165506
SGTC_2750 bromebric acid 70.15 µM -1.50112604203503 0.0667759559840928 no 3133 0.0666614821417109 4494 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2680 butyl paraben 22.24 µM -1.50285236453674 0.0665495869495115 no 3134 0.0664385595602725 4580 7184 An antifungal and steroid mimetic.
SGTC_3268 9137683 49.47 µM -1.5047942701758 0.0662956593695782 no 3135 0.0661884886701403 4561 1953228
SGTC_1387 3342-1166 1.8 µM -1.5070935700566 0.0659959690952651 no 3136 0.0658933373552273 4483 3418228
SGTC_277 nystatin 15.5 µM -1.50844538754787 0.0658202641051243 no 3137 0.0657202870352758 4523 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1108 betulinic acid 729.144 nM -1.50885437693371 0.0657671764531374 no 3138 0.0656680005230017 4497 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_365 0121-0052 13.6 µM -1.51087976592263 0.0655047658767887 no 3139 0.065409543492657 4484 3101739
SGTC_1974 st069448 26.9 µM -1.51109628403816 0.0654767617715026 no 3140 0.0653819606680559 4491 6323587 YNR016C ACC1
SGTC_3046 9092212 49.47 µM -1.51510141065033 0.0649604178482706 no 3141 0.0648733622511894 4573 25236637
SGTC_68 0986-0284 82.829 µM -1.51572799064107 0.0648799253925213 no 3142 0.0647940734359166 4479 423278 YIL048W NEO1
SGTC_1732 st034308 51.822 µM -1.51932680248694 0.0644191092863993 no 3143 0.064340128230708 4387 830119
SGTC_1461 k072-0203 53.8 µM -1.52220783201189 0.0640520389930699 no 3144 0.0639785066574185 4396 5418714
SGTC_2811 7967822 32.47 µM -1.52681326318817 0.0634686438275288 no 3145 0.0634037262839604 4520 2232244
SGTC_1502 4534-4282 27.7 µM -1.52685447659081 0.0634634418333207 no 3146 0.0633986008553945 4501 3278949
SGTC_521 r062-0005 13.8 µM -1.53241063641029 0.0627651712222344 no 3147 0.0627105671825389 4443 2832033
SGTC_2165 5727197 32.143 µM -1.53247255201929 0.0627574238431823 no 3148 0.062702932929043 4553 1361712
SGTC_769 0302-0231 76 µM -1.5333410938878 0.0626488234302854 no 3149 0.062595917219948 4423 571869 YER009W NTF2
SGTC_3267 9137951 49.47 µM -1.53348123262292 0.0626313145476292 no 3150 0.0625786636432437 4538 16643986
SGTC_2686 alizarin 95.37 µM -1.55189785878431 0.0603633551794795 no 3151 0.0603433326729161 4495 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1363 1636-0063 10.4 µM -1.55293571174713 0.0602374848607643 no 3152 0.0602192470304982 4530 6072185
SGTC_1703 st026983 48.3 µM -1.55362654068712 0.0601538154087041 no 3153 0.0601367623483486 4548 1104023
SGTC_1316 1272-0050 65.9 µM -1.55744753576384 0.0596926794774649 no 3154 0.059682133780685 4522 7340392
SGTC_3209 9113616 49.47 µM -1.55827183378698 0.0595935634180133 no 3155 0.059584411434871 4555 16649353
SGTC_2408 sulbentine 18.36 µM -1.5613673033305 0.059222506083732 no 3156 0.0592185559593986 4391 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_545 4218-0007 221 µM -1.56442482703261 0.0588577783896604 no 3157 0.0588589170160237 4529 2840508
SGTC_970 1315-0089 19.5 µM -1.57068485929555 0.0581165285602059 no 3158 0.0581279338937486 4512 6811083 YLR033W RSC58
SGTC_551 k048-0028 34.9 µM -1.5709082842056 0.0580902090349848 no 3159 0.0581019770339975 4499 6836383
SGTC_3274 9138298 49.47 µM -1.57110726699352 0.0580667766856055 no 3160 0.0580788674578885 4498 17015756
SGTC_2357 9067248 200 µM -1.57497272813903 0.057613049404839 no 3161 0.0576313698308994 4491 9150235
SGTC_777 1315-0167 517 µM -1.58492192271663 0.0564580352977674 no 3162 0.056492037446405 4564 4221767
SGTC_1070 indatraline 8.81 µM -1.59433876624446 0.0553817075011215 no 3163 0.0554300896741254 4589 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2558 carylophyllene oxide 100 µM -1.59648113645455 0.055139115483986 no 3164 0.0551907070102033 4636 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_794 k038-0031 316 µM -1.59712320223402 0.0550665746718998 no 3165 0.0551191235769481 4522 6624242
SGTC_1484 3473-2379 286 µM -1.59773547066316 0.0549974706280251 no 3166 0.0550509305684693 4648 671917
SGTC_187 1488-2104 32.728 µM -1.60040384058404 0.0546971032082449 no 3167 0.0547545118348155 4542 2852859
SGTC_315 k915-0449 187 µM -1.60194460523054 0.0545242572226544 no 3168 0.0545839298089245 4576 20970215 YNL149C PGA2
SGTC_2104 5389443 200 µM -1.61429149046549 0.0531547143955216 no 3169 0.0532321075053396 4558 2244536
SGTC_628 1636-0253 16 µM -1.61652050662565 0.0529103986893965 no 3170 0.0529909116905085 4547 4456143
SGTC_299 1273-0059 1.44 µM -1.62155047511398 0.052362351889926 no 3171 0.0524498170423628 4326 2848077
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.62179101860476 0.052336256509202 no 3172 0.0524240510789552 4544 5377381
SGTC_3121 9125696 49.47 µM -1.6234380486071 0.0521578556280892 no 3173 0.0522478983079877 4651 1235365
SGTC_82 0054-0107 293.755 µM -1.63176316143966 0.0512634861198501 no 3174 0.05136469428326 4540 3104697
SGTC_2206 7254556 146.969 µM -1.63350990277541 0.0510773906649439 no 3175 0.0511808998554714 4585 4398905
SGTC_819 1013-0258 27.7 µM -1.64457538060795 0.049910949654915 no 3176 0.0500287036824215 4579 5753198
SGTC_2297 7971671 152.32 µM -1.64732281569693 0.0496246526031906 no 3177 0.0497458553438151 4554 909016
SGTC_123 0083-0120 66.675 µM -1.64755648209476 0.0496003639373715 no 3178 0.0497218583822674 4548 16001701
SGTC_1778 st046819 58.9 µM -1.64983944691439 0.0493635579071221 no 3179 0.0494878891577508 4606 671715
SGTC_1822 st052468 42 µM -1.66217727670005 0.0480993662096269 no 3180 0.0482386173780461 4588 2873678
SGTC_1870 st057514 26.5 µM -1.66967702483054 0.0473436552213427 no 3181 0.0474916408911547 4578 5393161
SGTC_1953 st076800 12.1 µM -1.67196639751382 0.0471148720189068 no 3182 0.0472654741806616 4542 297591
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.67447263141881 0.0468654344346097 no 3183 0.0470188744163229 4577 641818 YHR062C RPP1
SGTC_2537 larixol 68.93 µM -1.67472563446808 0.0468403128067044 no 3184 0.0469940377290724 4547 6708759
SGTC_1966 st070145 16.1 µM -1.67595001618972 0.0467188919038021 no 3185 0.0468739917961729 4552 3748532
SGTC_1620 st003704 16.5 µM -1.6769593273152 0.0466189893657992 no 3186 0.0467752177644324 4591 2834414
SGTC_83 0170-0301 39.027 µM -1.67785834824505 0.0465301478698513 no 3187 0.0466873777063663 4601 3089716
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.6821469934218 0.046108211311478 no 3188 0.0462701698605546 4601 66535 A nucleotide analog.
SGTC_2031 5180455 200 µM -1.68358468062324 0.0459674548118213 no 3189 0.046130980696122 4581 29949
SGTC_3089 9117425 49.47 µM -1.68403685991435 0.0459232557160652 no 3190 0.0460872727075472 4553 9401657
SGTC_1583 clindamycin 39.6 µM -1.68789014021121 0.0455479936143629 no 3191 0.0457161598425904 4567 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1269 0831-0796 3.05 µM -1.68920306597766 0.0454206954082113 no 3192 0.0455902608272956 4615 927758
SGTC_120 rhodamine 6G 52.259 µM -1.69980072487883 0.0444036168866933 no 3193 0.0445842075745992 4583 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_118 0083-0097 135.343 µM -1.70208190747119 0.0441871056017404 no 3194 0.0443700075088229 4570 5207356
SGTC_993 3909-8757 62.7 µM -1.70373257600134 0.0440309689140224 no 3195 0.0442155296465002 4555 4288324 YLR208W SEC13
SGTC_1863 st057641 20.1 µM -1.70459946374804 0.0439491483743495 no 3196 0.0441345757260122 4645 3921635
SGTC_3220 9131269 49.47 µM -1.70587264273312 0.0438292026851766 no 3197 0.0440158971511997 4594 17722206
SGTC_2904 7225135 42.03 µM -1.70769800517462 0.0436576968541267 no 3198 0.0438461962461015 4655 4446116
SGTC_2168 5727979 200 µM -1.71206058380946 0.043249994785078 no 3199 0.0434427521289046 4512 695210
SGTC_2601 securinine 100 µM -1.71236984506493 0.0432212100661404 no 3200 0.0434142662806682 4542 442872 A GABA receptor antagonist.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.7170307222484 0.0427892662882376 no 3201 0.0429867793835922 4569 5379071
SGTC_2728 chlorpromazine 9.18 µM -1.72216193824554 0.0423177762199206 no 3202 0.0425200937867374 4678 2726 A thorazine and dopamine antagonist.
SGTC_750 4073-0104 132 µM -1.72850095900043 0.0417411180282409 no 3203 0.0419492246201278 4282 22330957
SGTC_2388 9080168 200 µM -1.73036901036301 0.0415724015013096 no 3204 0.0417821834704039 4625 15943073
SGTC_260 nsc-65238 3.989 µM -1.73136324588994 0.0414828308016029 no 3205 0.041693498813277 4593 3246252
SGTC_1471 k673-0312 37 µM -1.73392043082434 0.0412531721504859 no 3206 0.0414661011194671 4598 24099884
SGTC_643 k048-0106 28.4 µM -1.73843391457018 0.0408503357361987 no 3207 0.0410671925774673 4631 6763920
SGTC_2723 salbutamol 83.58 µM -1.74057631903156 0.0406602423985484 no 3208 0.0408789357967261 4614 9884233 β2-adrenoceptor agonist
SGTC_153 4077-0274 519.67 µM -1.74620043736612 0.040164634516237 no 3209 0.040388064430484 4605 3121976
SGTC_1135 dihydrocapsaicin 536.708 nM -1.7667461173588 0.0383956684158996 no 3210 0.0386353781058202 4530 107982 A Capsaicinoid.
SGTC_2359 9039622 200 µM -1.77836164285313 0.0374240187322253 no 3211 0.0376722390826977 4573 6463596
SGTC_854 0422-0053 192 µM -1.78162781069109 0.0371544476139994 no 3212 0.037404973066268 4635 3596728
SGTC_2012 4023501 200 µM -1.78997214772467 0.0364729526350157 no 3213 0.0367291945234626 4601 3477460
SGTC_3002 9075603 71.4286 µM -1.8000095890877 0.035666767521182 no 3214 0.0359295620594674 4576 20105405
SGTC_743 1275-0778 158 µM -1.8001205530597 0.0356579374339751 no 3215 0.0359208024623745 4611 2849257 YMR203W TOM40
SGTC_707 0865-0008 204 µM -1.81087559330423 0.034810557775965 no 3216 0.0350800557034054 4676 723043
SGTC_2702 st077768 96.8 µM -1.81117556005912 0.0347871627445975 no 3217 0.0350568400606735 4591 6484119
SGTC_838 0109-0203 71.4 µM -1.81716511670131 0.0343227209385725 no 3218 0.0345959172660065 4655 759422
SGTC_161 4065-0411 162.148 µM -1.81930067848507 0.0341583627470319 no 3219 0.03443278497194 4615 1906281 YLR208W SEC13
SGTC_1300 1094-0077 113 µM -1.82142061508759 0.0339958476215755 no 3220 0.0342714719165185 4618 5532636
SGTC_2132 5317594 122.667 µM -1.82248947109491 0.0339141501605692 no 3221 0.0341903749390563 4581 794577
SGTC_747 3448-8087 38.7 µM -1.82621585669527 0.0336305877841956 no 3222 0.0339088768870088 4659 5168703
SGTC_972 1319-0219 195 µM -1.82754294379254 0.0335300743872336 no 3223 0.0338090877695671 4625 23903702
SGTC_1076 itraconazole 331 nM -1.83105580526094 0.0332652038857899 no 3224 0.0335461070315811 4646 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_804 1595-0054 20.9 µM -1.83803272581914 0.0327442522072788 no 3225 0.0330287915774458 4639 761523 Stimulates phospholipase C.
SGTC_1897 st060201 15 µM -1.84199364491923 0.0324515045374629 no 3226 0.0327380397320395 4629 611878
SGTC_1212 0520-0165 585 µM -1.84937097402243 0.031912009811584 no 3227 0.0322021318564948 4655 5403258
SGTC_2037 5169046 200 µM -1.85158323039012 0.0317516815618397 no 3228 0.0320428464722585 4685 5718022
SGTC_261 5-fluorouridine 15.376 µM -1.85274481469908 0.0316677651947822 no 3229 0.0319594716847104 4647 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3035 9091303 49.47 µM -1.86081401503619 0.0310898670443259 no 3230 0.0313852228140233 4678 25237002
SGTC_1136 pergolide 1.05886 µM -1.86481254793489 0.0308067502052731 no 3231 0.0311038419192304 4592 47811 A dopamine receptor agonist.
SGTC_225 nsc-122657 1.016 µM -1.86613166143164 0.030713819636355 no 3232 0.0310114736275135 4650 275685
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.87708694624247 0.0299509623216344 no 3233 0.030253089106996 4698 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_40 0327-0103 19.753 µM -1.87779772118921 0.0299020161060389 no 3234 0.0302044210689915 4505 409036
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.87942188402698 0.0297904200793703 no 3235 0.0300934552591061 4666 7104
SGTC_1185 1319-0113 81.3 µM -1.8909772189221 0.0290063894987623 no 3236 0.0293136926653055 4688 4672763
SGTC_265 mycophenolic acid 32.932 µM -1.89252316085751 0.0289028095529532 no 3237 0.0292106553709714 4693 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2694 st077685 81.9 µM -1.8933497378459 0.0288475541667627 no 3238 0.0291556874146828 4590 2838096
SGTC_3167 9103034 49.47 µM -1.89993004291462 0.0284107958642534 no 3239 0.0287211504122353 4718 5127859
SGTC_134 0269-0018 6.916 µM -1.905414714137 0.028050975857626 no 3240 0.028363092016175 4614 4378915
SGTC_2486 5283202 22.39 µM -1.9076436162609 0.0279058378881524 no 3241 0.0282186468871596 4652 1377751
SGTC_1871 st057448 67.3 µM -1.91222461129198 0.0276095037477237 no 3242 0.0279236953294264 4653 691747
SGTC_1462 k081-0014 26.5 µM -1.95054808236668 0.0252317530058818 no 3243 0.0255554141638733 4109 3270634
SGTC_2924 9010168 62.78 µM -1.95329959598591 0.0250678499234115 no 3244 0.0253920526759738 4652 2993929
SGTC_3025 9087895 49.47 µM -1.95650905632527 0.0248777963065435 no 3245 0.0252026083287811 4682 17173641
SGTC_1951 sophoraflavanone G 9.2 µM -1.95654340268338 0.0248757689820019 no 3246 0.0252005873943106 4621 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2111 5486399 200 µM -1.96215235830006 0.0245465490459815 no 3247 0.0248723743422278 4641 689674
SGTC_2305 7443522 69.23 µM -1.96446839826855 0.0244116788304314 no 3248 0.0247378987946451 4594 5415886
SGTC_569 4130-2812 160 µM -1.96617540182115 0.0243126733990942 no 3249 0.0246391764280248 4612 743552
SGTC_1104 tacrolimus 29.8 µM -1.96766988644367 0.0242262709904436 no 3250 0.0245530164237852 4719 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2529 gangaleoidin 93.61 µM -1.97340754323979 0.0238969449672177 no 3251 0.0242245744473829 4657 4565183
SGTC_1202 1988-0068 29.6 µM -1.97969326958353 0.0235404884448481 no 3252 0.0238690026538626 4665 2850480
SGTC_2228 7354201 200 µM -1.9802281790017 0.0235103619196776 no 3253 0.0238389474239115 4742 753451
SGTC_1594 piperine 70.1 µM -1.99293997624782 0.0228039111388849 no 3254 0.0231340100872435 4665 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1071 trifluoperazine 6.31 µM -2.00153580120573 0.0223364099205355 no 3255 0.0226673398066457 4702 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2222 6885208 172.143 µM -2.00451631444205 0.0221762079116792 no 3256 0.0225073905403706 4716 609514
SGTC_2478 5763493 32.33 µM -2.01741043862306 0.0214942780492022 no 3257 0.0218263494113976 4656 1365576 YLR208W SEC13
SGTC_1836 st055642 81 µM -2.02457666836085 0.0211230010574851 no 3258 0.0214554260189621 4672 8571
SGTC_122 0236-0016 402.397 µM -2.02783409440476 0.0209560383314981 no 3259 0.0212885916827322 4674 6808838
SGTC_1226 3909-7979 35.4 µM -2.03313414728226 0.0206867661906364 no 3260 0.0210194859621279 4679 6615510
SGTC_8 0354-0001 70 µM -2.03393395569517 0.020646387045191 no 3261 0.0209791274069608 4686 4993152
SGTC_2429 5902844 64.44 µM -2.03395371295166 0.0206453904254036 no 3262 0.0209781312808902 4688 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1937 st074714 47.2 µM -2.03646564416786 0.0205190119938225 no 3263 0.0208518097839643 4651 17250970
SGTC_1981 st071826 47 µM -2.04791590667804 0.0199512071703882 no 3264 0.0202841199852117 4720 11838600
SGTC_2376 9072922 81.32 µM -2.04817880941525 0.0199383282882198 no 3265 0.0202712410038733 4685 17087968
SGTC_71 0417-1750 47.813 µM -2.05890772307875 0.0194187332359314 no 3266 0.0197515395545782 4659 6811472
SGTC_305 1682-2595 20.8 µM -2.06284402343615 0.0192310069106114 no 3267 0.0195637249282359 4695 226033
SGTC_325 2810-4341 181 µM -2.06598526284811 0.0190823066086971 no 3268 0.0194149355679102 4705 774970
SGTC_549 1661-1316 519 µM -2.07439901368216 0.0186888238784481 no 3269 0.0190211344267095 4723 2857282
SGTC_2795 7780010 54.55 µM -2.08538446036946 0.0181854838611504 no 3270 0.0185172081307928 4666 953673
SGTC_314 1671-0008 2.74 µM -2.08793310581612 0.0180703733139393 no 3271 0.0184019346688278 4589 3913060
SGTC_904 1141-0088 396 µM -2.10077271318062 0.0174998700662743 no 3272 0.0178304614220131 4702 1378119
SGTC_1294 1000-1494 117 µM -2.10343217553777 0.0173836441780149 no 3273 0.0177140041559273 4723 712797 YDL207W GLE1
SGTC_1443 4112-3303 14 µM -2.10479418758614 0.0173243761610776 no 3274 0.0176546136771218 4735 704433
SGTC_2227 7312221 64.1025 µM -2.10623955108761 0.0172616699495466 no 3275 0.0175917745923329 4762 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2016 5121758 140 µM -2.10657216376658 0.0172472672272263 no 3276 0.0175773408692222 4632 2795203
SGTC_1341 1486-1360 280 µM -2.11292741471187 0.0169740393202319 no 3277 0.0173034905002503 4712 3976547
SGTC_3014 9081533 49.47 µM -2.11673519963075 0.0168121126791755 no 3278 0.0171411638363627 4706 21367265
SGTC_2911 7942208 15.64 µM -2.11699991812308 0.016800904767889 no 3279 0.0171299273711258 4685 1243384
SGTC_3211 9128781 49.47 µM -2.12697197227981 0.0163833282661041 no 3280 0.0167112060139591 4610 17194361
SGTC_1777 st045864 34.765 µM -2.13066683957444 0.0162308794764414 no 3281 0.0165582994010022 4719 4691462
SGTC_1914 st062367 72.6 µM -2.13910055850903 0.0158874538541493 no 3282 0.0162137625980326 4684 978205
SGTC_1857 st056007 79.3 µM -2.1496075835467 0.0154683345638927 no 3283 0.015793134026695 4712 619834
SGTC_2251 lansoprazole 556 µM -2.15155586255678 0.0153916709983842 no 3284 0.0157161757919109 4703 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_22 0964-0034 14.468 µM -2.15338220190909 0.0153201021562088 no 3285 0.0156443265980367 4720 138402
SGTC_1941 st076221 61.8 µM -2.17002311739411 0.0146810561439007 no 3286 0.0150025473583007 4636 2828568
SGTC_2217 6934799 96.0675 µM -2.1750354802265 0.0144931219779865 no 3287 0.0148137288481634 4722 675606
SGTC_200 k038-0079 37.545 µM -2.17957110487978 0.0143248511380183 no 3288 0.0146446343105233 4736 3436683
SGTC_248 streptozotocin 5.23457 mM -2.1854702318541 0.0141085138923222 no 3289 0.0144271931389925 4740 5300 DNA alkylating agent.
SGTC_2858 9025781 8.96 µM -2.18585761519331 0.0140944065153436 no 3290 0.014413012000018 4543 4894980 YPL153C RAD53
SGTC_1265 0819-1001 68.8 µM -2.19230570486241 0.0138613648983581 no 3291 0.0141787200541419 4678 3106768
SGTC_531 3788-1495 174 µM -2.20058282939755 0.0135670958927051 no 3292 0.0138827851288325 4718 2896655
SGTC_664 1222-0054 14.9 µM -2.20244440936933 0.0135016605549442 no 3293 0.0138169659170962 4718 6813991
SGTC_1847 st056231 15 µM -2.2198012446685 0.0129045606909494 no 3294 0.01321613120334 4725 5393180
SGTC_354 2783-3500 4.88 µM -2.22648504697488 0.0126807944090481 no 3295 0.0129908547355269 4716 6740761
SGTC_2236 dapsone 200 µM -2.22680132010221 0.0126702896546134 no 3296 0.0129802775675118 4740 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2480 5767542 37.17 µM -2.23039518937438 0.0125514502089094 no 3297 0.0128606093327305 4687 2867358
SGTC_2832 7992762 51.95 µM -2.23794813662618 0.0123048363011254 no 3298 0.0126122187158523 4658 2985177
SGTC_91 0417-1751 58.384 µM -2.24171612924373 0.0121833835731863 no 3299 0.0124898623855753 4758 6795624
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.27860396224276 0.0110482334389773 no 3300 0.0113453091008347 4731 23847180
SGTC_647 0140-0236 81 µM -2.28921164618411 0.0107393276599732 no 3301 0.0110335291283077 4748 990837
SGTC_2231 micatex 6.853 µM -2.29259410162177 0.0106424216125453 no 3302 0.0109356921419939 4741 20737 An antifungal of unknown mechanism.
SGTC_2464 5717415 7.67 µM -2.30385237467775 0.0103253417696302 no 3303 0.0106154659571786 4711 5285744
SGTC_1779 st039427 55 µM -2.31234657781291 0.0100915918825145 no 3304 0.0103792959050075 4722 1124498
SGTC_1978 st071761 42 µM -2.3301747070321 0.00961595431068713 no 3305 0.00989845960590339 4751 5147680
SGTC_1648 st011736 69.8 µM -2.33529416332752 0.00948304470658457 no 3306 0.00976402943822734 4742 2855514
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -2.3633337379277 0.00878321245645243 no 3307 0.00905567566132008 4745 6708784 An antioxidant flavonoid
SGTC_429 1112-0049 25.5 µM -2.38249285100108 0.008331455572879 no 3308 0.00859793293289542 4706 2836170
SGTC_1678 st019265 80.2 µM -2.38399976170516 0.00829680502371662 no 3309 0.00856280672997248 4732 5367020
SGTC_3286 9117135 37.221 µM -2.42179887812474 0.0074680673419804 no 3310 0.00772194766475082 4715 3438150
SGTC_266 formosanin C 406 nM -2.42499446731565 0.00740146869616119 no 3311 0.0076543100280813 4663 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2468 5987765 72.9 µM -2.44162630611378 0.00706323012267985 no 3312 0.0073106363483667 4765 26772094
SGTC_7 0192-1582 4.227 µM -2.44521160858767 0.00699212951953631 no 3313 0.00723835875639728 4765 252616
SGTC_2153 5569715 200 µM -2.48217287303758 0.00629517645500132 no 3314 0.00652919531788732 4771 2054701
SGTC_555 4296-0685 37 µM -2.50044540678152 0.00597390953753547 no 3315 0.00620186244725091 4773 2908540 YHR072W ERG7
SGTC_387 norethindrone acetate 66.7 µM -2.52920104291326 0.00549771944490264 no 3316 0.00571612607411634 4767 541197
SGTC_1804 st050076 49.1 µM -2.54757263399154 0.00521143806484198 no 3317 0.00542376343920638 4772 3895976
SGTC_2234 tolnaftate 200 µM -2.60178583774521 0.00444241397471069 no 3318 0.00463698728509678 4791 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2636 apigenin dimethyl ether 100 µM -2.63659968031849 0.00400367180853537 no 3319 0.0041870796183912 4744 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2152 5568786 200 µM -2.64728650982993 0.00387700115781973 no 3320 0.00405702875387826 4784 5399883
SGTC_220 paclitaxel 373.376 µM -2.66988679472112 0.00362087925823533 no 3321 0.00379384120300401 4765 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_453 enantio-paf c16 10 µM -2.67948741542949 0.00351675202502647 no 3322 0.00368674874249295 4359 13871343 A lipid and platelet activating factor
SGTC_2703 st077852 53.4 µM -2.71356937214269 0.00316847139576566 no 3323 0.00332813149432481 4777 6281836
SGTC_2018 5133068 143 µM -2.72853165840682 0.00302562744164862 no 3324 0.00318084917064723 4758 785362
SGTC_3181 9108277 49.47 µM -2.74923429973195 0.00283754655340397 no 3325 0.0029867335136166 4776 17097298
SGTC_2842 9000675 19.48 µM -2.75738969425191 0.00276639867481648 no 3326 0.00291324338307909 4757 2989072
SGTC_2929 9013348 24.6 µM -2.75823227168199 0.00275914053836458 no 3327 0.00290574440678988 4761 2995952
SGTC_2250 alverine citrate 130 µM -2.79893250062044 0.00242835847465059 no 3328 0.00256359270919308 4693 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1982 st072467 71.9 µM -2.80614046694599 0.0023736655939771 no 3329 0.00250694151538917 4777 3163533
SGTC_982 1491-0518 27.5 µM -2.82742203327118 0.00221862822426028 no 3330 0.00234622202372578 4780 3091256
SGTC_1934 st074720 32.6 µM -2.83382981652909 0.00217377844569951 no 3331 0.00229969093960793 4751 17250992
SGTC_2154 5570129 200 µM -2.83998571591237 0.00213146740409593 no 3332 0.00225577769787287 4795 673366
SGTC_1768 st044301 37.178 µM -2.91056867030266 0.00169699089504762 no 3333 0.00180385839219077 4794 3931349
SGTC_304 1310-0298 97 µM -2.91350890778753 0.00168077983492739 no 3334 0.00178695820258869 4635 1550234
SGTC_2224 6650123 117.647 µM -2.92921542500674 0.00159654583771055 no 3335 0.00169909408780217 4805 2908370
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.96791698261432 0.00140515504253914 no 3336 0.00149912648738542 4778 364106
SGTC_1477 0139-0234 16 µM -2.9891273383987 0.00130938511111956 no 3337 0.00139887752627401 4798 620880
SGTC_1726 st035556 14.5795 µM -2.99925016860913 0.00126581517168074 no 3338 0.00135322491087222 4781 5919439
SGTC_2162 5663267 200 µM -3.00193421087278 0.00125448727122801 no 3339 0.00134135072999077 4793 6456493
SGTC_1745 st081495 74 µM -3.04037363414949 0.00110211323169845 no 3340 0.00118142410807361 4721 13842402 YBL026W LSM2
SGTC_2651 TUB2.036 5 µM -3.04711939798129 0.00107719228115208 no 3341 0.00115522957531107 4711 15992207 YFL037W TUB2
SGTC_1331 1472-0049 76.2 µM -3.07093263726887 0.000993292966107908 yes 3342 0.0010669564401596 4792 24051409
SGTC_309 k408-0051 1.48 µM -3.13551238706502 0.00079503363387519 yes 3343 0.00085777091610355 4759 3640463
SGTC_1902 st060212 70.5 µM -3.18568173089141 0.000666912298455978 yes 3344 0.000722066858936245 4790 688944
SGTC_2138 5575593 77.673 µM -3.19177445641238 0.000652723095533644 yes 3345 0.000707008503428147 4800 762213
SGTC_87 0100-0052 35.5 µM -3.19603813207484 0.000642959796977651 yes 3346 0.000696643483932996 4794 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2438 5259590 200 µM -3.33952475655112 0.00038324860749382 yes 3347 0.00041960935239262 4803 1201127
SGTC_2442 5158906 48.48 µM -3.37436576328657 0.000336989329049876 yes 3348 0.000369929952055843 4798 1893835
SGTC_1093 fluphenazine 7.97 µM -3.40767452179884 0.000297667679095408 yes 3349 0.000327594976195185 4803 6602611 An atypical antipsychotic.
SGTC_2017 5132927 60.65 µM -3.62705315945852 0.000127986185422968 yes 3350 0.000143337145178638 4796 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_821 1114-0266 29.2 µM -3.70241289843161 9.47439382138276e-05 yes 3351 0.000106779344474368 4806 3123235
SGTC_1814 st052110 31.539 µM -3.72341493508021 8.70407922493888e-05 yes 3352 9.82730513904681e-05 4802 674163
SGTC_2701 st077767 14.721 µM -3.86252411971758 4.90978148631687e-05 yes 3353 5.61107406999029e-05 4801 5721188
SGTC_667 1498-1044 59 µM -4.05497014479951 2.15525698855615e-05 yes 3354 2.50703532278669e-05 4804 6739982
SGTC_59 0330-0160 1.33 µM -4.10129950889336 1.75817674474488e-05 yes 3355 2.05418190930541e-05 4788 4293482
SGTC_58 0957-0393 9 µM -10.1805470943002 3.43950188710774e-25 yes 3356 1.21097918909438e-24 4789 6997992