SGTCid condition conc unit SLI1|YGR212W.score SLI1|YGR212W.strain.pval SLI1|YGR212W.strain.significant SLI1|YGR212W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1876 myriocin 605 nM 40.3511937867038 0 yes 1 0 1 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_864 0469-0573 172 µM 6.51535279635396 6.21253240277895e-11 yes 2 3.62595050627058e-11 1 689425
SGTC_421 streptovitacin 30 mM 4.58970727569677 3.01926597015084e-06 yes 3 2.21934019461522e-06 13 91467 include heat shock
SGTC_3098 9119039 49.47 µM 4.34452456662672 9.26225859250984e-06 yes 4 6.97888118389711e-06 28 17161528
SGTC_159 3970-0959 50 µM 4.34164701966628 9.38175772456384e-06 yes 5 7.07093002019403e-06 61 6615653
SGTC_3173 9105693 49.47 µM 4.3136343598813 1.06244047481924e-05 yes 6 8.02962327226488e-06 12 17096658
SGTC_867 0518-0118 155 µM 4.08524657159694 2.84958061399874e-05 yes 7 2.20150172502863e-05 18 6848158
SGTC_424 splitomicin 100 mM 3.8991459500244 6.1407071985031e-05 yes 8 4.82662885655564e-05 23 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2108 5365811 200 µM 3.84109935057001 7.75075594671814e-05 yes 9 6.12422623216609e-05 14 780283
SGTC_2787 5284540 71.43 µM 3.81225122635985 8.69148155340772e-05 yes 10 6.88534015761856e-05 28 736958
SGTC_1371 2421-0008 32.7 µM 3.74043724155877 0.000115206469554887 yes 11 9.18502056666981e-05 48 2827552
SGTC_1780 st038448 24.544 µM 3.67003706062301 0.000151156492305814 yes 12 0.000121257652670046 30 728868 YDL195W SEC31
SGTC_998 3996-0085 177 µM 3.66221729362647 0.000155741626822779 yes 13 0.00012502081241051 31 715391
SGTC_1774 st048371 48.465 µM 3.4708466024979 0.000317927794070348 yes 14 0.000259410145305119 36 4242727
SGTC_1285 0929-0069 65.5 µM 3.469399310078 0.000319606972278173 yes 15 0.000260811774902504 37 1206237
SGTC_3191 9110352 49.47 µM 3.45308969397517 0.000339108636472528 yes 16 0.00027710234742348 24 17122424
SGTC_46 0329-0187a 2.197 µM 3.34021448571534 0.000507498405624848 yes 17 0.000418568545646455 101 46494817
SGTC_857 0438-0306 1.35 µM 3.2643895805041 0.00066098636495427 yes 18 0.000548501064426042 28 4686136
SGTC_3188 9110789 49.47 µM 3.24215029158154 0.000713534564997486 yes 19 0.000593157216857645 54 849217
SGTC_848 0368-0089 85.6 µM 3.23785259265284 0.000724123161755183 yes 20 0.000602165091267127 35 762535
SGTC_20 0481-0013 4.944 µM 3.22024340249862 0.000769038318088669 yes 21 0.000640408987967106 57 182045
SGTC_2296 7971656 126.45 µM 3.20683972840555 0.000804931265100399 yes 22 0.000671008703780494 79 666570
SGTC_1128 3448-9350 235 µM 3.09932013566004 0.00115367902109822 no 23 0.000969826548933949 58 619386
SGTC_1896 st058441 89 µM 3.08746661017507 0.00119960375439645 no 24 0.0010093522438535 43 688759
SGTC_786 4544-0069 423 µM 3.03350633243653 0.00143056124118848 no 25 0.00120864818976999 77 748821 YLR208W SEC13
SGTC_3097 9117246 49.47 µM 3.02484266851304 0.00147121576774147 no 26 0.00124381247548396 47 16423892
SGTC_2010 4012422 159 µM 3.0189476688588 0.00149947805532648 no 27 0.00126827170892274 68 952393
SGTC_207 4185-0010 4.486 µM 3.0100135858638 0.00154325561022114 no 28 0.00130618002188558 148 3761753
SGTC_761 k216-0224 480 µM 2.93952583550825 0.00193167474670155 no 29 0.00164357432353098 74 1340404
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.93631896861501 0.00195129483015809 no 30 0.0016606630745233 62 4330530
SGTC_1363 1636-0063 10.4 µM 2.92690488867574 0.0020099416750224 no 31 0.00171176780028314 80 6072185
SGTC_769 0302-0231 76 µM 2.91818913547454 0.00206565993449687 no 32 0.00176035364353079 124 571869 YER009W NTF2
SGTC_3158 9100007 49.47 µM 2.89479146398484 0.00222223639869227 no 33 0.00189705247525188 57 19297233
SGTC_96 0929-0093 37.281 µM 2.87716238058404 0.00234723065235213 no 34 0.00200634524611384 58 6991579
SGTC_1233 0325-0408 14.2 µM 2.87618283594736 0.00235435898742067 no 35 0.00201258241838069 69 12874
SGTC_196 k015-0023 18.111 µM 2.86547385844466 0.00243357837282441 no 36 0.00208192825135959 66 5211998
SGTC_2541 muurolladie-3-one 83.07 µM 2.86476782532495 0.00243888501229986 no 37 0.00208657545209236 86 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3197 9113331 49.47 µM 2.85412241853255 0.00252017619206008 no 38 0.00215779490106198 117 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1990 st072050 59.8 µM 2.85160891003218 0.00253972401348079 no 39 0.00217492910955422 62 17233948
SGTC_2210 7115885 190.385 µM 2.83547006405585 0.00266853663181765 no 40 0.00228791516344587 82 2927039
SGTC_1616 st002734 56.1 µM 2.82635456693337 0.00274387220872727 no 41 0.00235405589089204 96 4026101
SGTC_856 0433-0016 11.3 µM 2.80356094008334 0.00294072263360959 no 42 0.0025270839932337 61 3911780
SGTC_2732 terfenadine 20 µM 2.7907894523412 0.00305650128656625 no 43 0.00262898315876556 41 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2467 5474540 200 µM 2.76928217525741 0.00326077944016665 no 44 0.00280899780335919 86 5413519
SGTC_1865 st057639 52.2 µM 2.73646421783997 0.00359620523287883 no 45 0.00310516742836695 69 688818
SGTC_490 phenamil 164 µM 2.71107132773248 0.00387665237009182 no 46 0.00335330987579302 45 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3077 9117319 49.47 µM 2.69523025791417 0.00406138158915833 no 47 0.0035170002216194 62 17154678
SGTC_2972 9093619 59.92 µM 2.67184282481236 0.00434852666114708 no 48 0.00377179864006955 89 25236256
SGTC_2253 7938677 135.83 µM 2.65087697322144 0.00462122106972116 no 49 0.00401415395502336 68 2301972
SGTC_266 formosanin C 406 nM 2.64279892228685 0.004730296239699 no 50 0.00411119248701589 163 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3248 9135562 49.47 µM 2.64266465021635 0.00473212850918848 no 51 0.00411282303140918 68 17650701
SGTC_160 3453-0671 289.699 µM 2.63087571399748 0.00489548828702948 no 52 0.00425825875136492 126 5322268
SGTC_1945 st075991 56.6 µM 2.61643003951361 0.0051025023275845 no 53 0.00444272854294217 98 1084980
SGTC_1297 1068-0111 14.1 µM 2.5800930468497 0.00565807687094711 no 54 0.00493868487219922 84 767057
SGTC_400 oxethazaine 37.5 µM 2.52974496899758 0.00651646623396525 no 55 0.00570727305934953 99 4621 A local anesthetic.
SGTC_3275 9138069 49.47 µM 2.5241812200405 0.00661805632402877 no 56 0.00579840648106382 67 17617007
SGTC_2830 7992007 71.43 µM 2.51531589715193 0.00678282521578542 no 57 0.00594628856486639 109 1952075
SGTC_1837 st055472 66.5 µM 2.49436245350031 0.00718674496692926 no 58 0.00630918104291257 117 676091
SGTC_1404 3909-7820 48.3 µM 2.49193122818162 0.00723495877774496 no 59 0.00635253174166647 87 23741373
SGTC_3348 9149464 3.537 µM 2.48067779305219 0.00746186136015815 no 60 0.0065566424336966 109 1951442
SGTC_301 4119-0100 24.5 µM 2.43237491615601 0.00850852372537446 no 61 0.0075000857872192 197 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3268 9137683 49.47 µM 2.43128041587931 0.00853366286698363 no 62 0.00752278254268462 79 1953228
SGTC_1892 st058411 7.36 µM 2.42289611492971 0.00872840979953537 no 63 0.00769866455214395 140 3934738
SGTC_3085 9117376 49.47 µM 2.40917222706846 0.00905559733364368 no 64 0.00799437539731964 107 16480349
SGTC_3099 9120367 49.47 µM 2.40405554260065 0.00918030376406012 no 65 0.008107154768414 107 24824940
SGTC_121 0557-0495 61.343 µM 2.40208782287558 0.00922866076339783 no 66 0.00815089709181402 230 3104427
SGTC_92 0063-0024 660.874 µM 2.3906691944439 0.00951369935381429 no 67 0.00840884911916348 111 3594437
SGTC_2311 7694451 200 µM 2.38774517518654 0.00958791696182301 no 68 0.00847604567978101 136 2163142
SGTC_343 4130-2827 29.8 µM 2.38677864642266 0.00961256048890864 no 69 0.00849836076670501 139 1118244
SGTC_2884 9058502 51.95 µM 2.38520176417332 0.00965288500978658 no 70 0.008534878290151 142 6471554
SGTC_1968 st069590 43.6 µM 2.38406801584038 0.00968196885150268 no 71 0.00856121870562016 107 6384066
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.37079008028382 0.0100283266759155 no 72 0.00887505458042762 143 115019
SGTC_341 1486-1430 230 µM 2.35732012082543 0.0103906946439953 no 73 0.00920368545449366 151 2054753 YPL210C SRP72
SGTC_1759 st043059 70 µM 2.34139590915002 0.0108337644868805 no 74 0.00960589115617066 145 669426
SGTC_693 4161-2696 114 µM 2.33814874316215 0.0109261043836521 no 75 0.00968976669795307 85 805759
SGTC_98 0074-0023 107.663 µM 2.33369595360024 0.0110538417565453 no 76 0.00980582406197214 169 3563821
SGTC_427 1354-0053 47.3 µM 2.33236867408626 0.0110921679209628 no 77 0.00984065230198659 164 6813657
SGTC_1104 tacrolimus 29.8 µM 2.32154431298943 0.0114090668675004 no 78 0.0101287426927403 152 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2264 7948757 110.76 µM 2.31825003676402 0.0115070599007035 no 79 0.0102178680387975 142 2971411
SGTC_608 k048-0125 159 µM 2.31073694872185 0.0117332862741518 no 80 0.0104236945223145 130 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3176 9106582 49.47 µM 2.30238500885171 0.0119892925055939 no 81 0.0106567348128699 41 17018027
SGTC_254 nsc-64875 3.808 µM 2.29964855103265 0.0120742182414487 no 82 0.0107340695543985 137 56993
SGTC_3167 9103034 49.47 µM 2.29486288536428 0.0122239949683399 no 83 0.0108704916933201 66 5127859
SGTC_912 3474-0017 2.18 µM 2.29163908193962 0.0123257954397389 no 84 0.0109632391614532 149 3360550
SGTC_77 0828-0286 12.516 µM 2.29128250689727 0.0123371002617653 no 85 0.0109735398415134 187 745345
SGTC_665 3914-0008 307 µM 2.27980124363678 0.0127059331426289 no 86 0.0113097396116371 161 1069549
SGTC_1889 st059080 5.18 µM 2.2762979682919 0.0128203583888355 no 87 0.0114140908215567 157 176925 Isolated from Daphnopsis sellowiana.
SGTC_990 3985-0011 41.3 µM 2.27039738535844 0.0130151007885193 no 88 0.0115917414945724 130 5399565 YGL099W LSG1
SGTC_2300 7976697 71.57 µM 2.25792581139156 0.0134351418187211 no 89 0.0119751425518897 156 2236109
SGTC_944 3370-0224 231 µM 2.25128150505979 0.0136636630650108 no 90 0.0121838567255949 164 4580514
SGTC_1662 st014054 52 µM 2.24393201958933 0.0139203370975101 no 91 0.0124183877999607 102 2838777
SGTC_1159 4092-0538 61.2 µM 2.238160992492 0.0141247885844981 no 92 0.0126052791958532 172 717301
SGTC_854 0422-0053 192 µM 2.22574723886492 0.0145733582981529 no 93 0.0130155583308533 143 3596728
SGTC_734 2023-0417 80 µM 2.22297484518783 0.014675196635589 no 94 0.013108748112606 163 3935732
SGTC_2089 5281248 129.67 µM 2.2204884070787 0.0147670511576945 no 95 0.0131928158825432 169 2737878
SGTC_176 1486-1328 72.834 µM 2.21676197913897 0.0149056394009319 no 96 0.0133196804677449 242 22310231
SGTC_2737 bleomycin 30.5 nM 2.20475129465011 0.0153599608193626 no 97 0.0137357757532077 247 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1457 k015-0032 57.3 µM 2.18652916032326 0.016071926267181 no 98 0.0143884568405242 200 4302660
SGTC_25 0118-0223 35.662 µM 2.17314268371958 0.0166128092560535 no 99 0.0148847900144169 168 5333628
SGTC_517 1365-0151 113 µM 2.17282452478724 0.0166258517727606 no 100 0.0148967633681135 188 768657
SGTC_2797 7859098 81.82 µM 2.17068920827643 0.016713613276679 no 101 0.0149773367537936 177 972681
SGTC_197 4544-0043 41.561 µM 2.16917933312155 0.0167759080797548 no 102 0.0150345357698826 235 896523
SGTC_3285 9112818 20.8695 µM 2.16839365420515 0.016808402304027 no 103 0.0150643740560664 190 17017947 YPR165W RHO1
SGTC_2712 st079126 47.7 µM 2.16562652514456 0.0169232746565478 no 104 0.0151698688814336 159 3152970
SGTC_1281 0884-0031 11.8 µM 2.15987792897816 0.0171640643876612 no 105 0.0153910603923769 207 1548255
SGTC_108 0509-0257 621.132 µM 2.15499441136017 0.0173709128798455 no 106 0.0155811357754799 240 536624
SGTC_835 0312-0010 67.2 µM 2.15496200985998 0.0173722923708621 no 107 0.0155824035977071 149 1626196
SGTC_7 0192-1582 4.227 µM 2.15489334835141 0.0173752159377407 no 108 0.0155850905123856 264 252616
SGTC_334 1502-1024 68.5 µM 2.15390509157311 0.0174173419028233 no 109 0.0156238077987561 177 3296216
SGTC_834 0312-0008 75.7 µM 2.151783743267 0.0175080622510523 no 110 0.015707195411032 219 6385573 YIL048W NEO1
SGTC_764 1951-2361 146 µM 2.15174092701373 0.0175098974515272 no 111 0.0157088823888818 202 5438930
SGTC_2818 7996756 12.99 µM 2.15164431799461 0.0175140389337251 no 112 0.0157126893946776 119 2241621
SGTC_2872 9044037 25.97 µM 2.14428477852454 0.0178319991425976 no 113 0.0160050378437844 107 6465195
SGTC_1702 st027038 51 µM 2.14182435212882 0.0179393914108249 no 114 0.0161038095197872 181 5521182
SGTC_1380 2291-0730 164 µM 2.13972671002677 0.0180313840148835 no 115 0.016188429581179 180 2999191
SGTC_2630 antimycin a 100 µM 2.13741627064679 0.0181331740534877 no 116 0.0162820746006579 210 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_485 niflumic acid 177 µM 2.12883273058569 0.0185156359600971 no 117 0.016634050955585 154 4488 A COX2 inhibitor.
SGTC_3053 9095903 49.47 µM 2.12458129123433 0.0187075997813941 no 118 0.0168107831640321 109 17174018
SGTC_751 0833-0568 350 µM 2.12383471380887 0.0187414839923642 no 119 0.0168419835685151 179 6954252
SGTC_173 1273-0061 2.693 µM 2.12252136055226 0.0188012186879957 no 120 0.0168969904400072 338 2847414 YPL266W DIM1
SGTC_1147 3809-1045 12.3 µM 2.12244196034252 0.0188048352016909 no 121 0.0169003208595273 205 325925
SGTC_2731 amoxapine 43.43 µM 2.11860146121515 0.0189804700283693 no 122 0.0170620810723511 64 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_731 3966-0296 387 µM 2.10796255245006 0.0194743133480714 no 123 0.0175171143664935 181 660956
SGTC_2031 5180455 200 µM 2.10418331746713 0.0196523477880853 no 124 0.0176812295944001 152 29949
SGTC_2464 5717415 7.67 µM 2.10264046903071 0.0197254254408525 no 125 0.0177486047697003 191 5285744
SGTC_181 1447-1644 8.07 µM 2.09342164645326 0.0201669025623243 no 126 0.0181557658811344 205 534600
SGTC_1612 st002233 45.4 µM 2.08429421850133 0.0206122291814246 no 127 0.0185667064614491 181 1035021
SGTC_611 3453-1652 23.7 µM 2.08146951960547 0.0207517227637442 no 128 0.0186954756014646 229 1560575
SGTC_126 0417-1624 672.48 µM 2.07795211723713 0.0209265411836586 no 129 0.0188568847875821 267 41912 YDL195W SEC31
SGTC_1130 3454-2858 15.9 µM 2.0752952594794 0.0210594146306838 no 130 0.018979589269551 266 715628 YIL048W NEO1
SGTC_2607 solasodine 47.35 µM 2.06958403675875 0.0213474594900169 no 131 0.0192456571095553 243 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.06530895173508 0.0215652468377986 no 132 0.0194468885572555 214 5106787 A p450 inhibitor.
SGTC_1763 st044482 94.5 µM 2.06424340507237 0.0216198208026748 no 133 0.0194973220015607 203 88505
SGTC_1358 1509-0022 2.48 µM 2.06421380524875 0.0216213384774121 no 134 0.0194987245767984 190 3258434
SGTC_117 lucigenin 22.078 µM 2.06082617348089 0.0217956285984338 no 135 0.0196598132586312 295 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_19 0279-0214 38.434 µM 2.05956700872276 0.0218607131282013 no 136 0.0197199764408337 305 3566274 YBR002C RER2
SGTC_2734 clemastine 41.6 µM 2.05248220563927 0.0222299844376682 no 137 0.0200614113239986 74 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_175 3793-3120 23.7 µM 2.03496555023044 0.023165632337216 no 138 0.0209271697195362 210 5322297
SGTC_1668 st014914 51.6 µM 2.03384678203539 0.0232265010418882 no 139 0.0209835230273104 174 2839556
SGTC_70 0141-0289 43.283 µM 2.02789900427004 0.0235523661031553 no 140 0.0212852783991518 485 352408
SGTC_2888 9058547 12.99 µM 2.01952105298105 0.0240178916469935 no 141 0.0217165456919855 153 16476514
SGTC_3172 9105863 49.47 µM 2.012839501875 0.0243946755636167 no 142 0.022065758378516 90 2348785
SGTC_2822 7994718 71.43 µM 2.00608472367516 0.0247806206457896 no 143 0.0224236047147406 179 1018011
SGTC_1690 st023502 41.2 µM 2.0045766679039 0.0248674816633898 no 144 0.0225041615275621 188 24207482
SGTC_3006 9075424 71.4286 µM 2.00446615990241 0.0248738567331847 no 145 0.0225100741907207 203 7465181
SGTC_772 k072-0172 35.3 µM 2.00266729696253 0.0249778237981103 no 146 0.0226065056124232 194 5861980
SGTC_1954 st077032 68.9 µM 2.0006335668232 0.025095803802525 no 147 0.0227159467285267 198 698907
SGTC_188 3229-0966 278.469 µM 1.99901020999896 0.0251903122880105 no 148 0.0228036245872614 269 5722370
SGTC_634 1611-4317 11.2 µM 1.99153947585839 0.0256290960837356 no 149 0.0232108048941274 241 2843522
SGTC_1071 trifluoperazine 6.31 µM 1.97874678572727 0.0263953132431405 no 150 0.0239222612664909 231 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2750 bromebric acid 70.15 µM 1.97446850323307 0.0266557947695487 no 151 0.0241642477122527 258 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1303 1160-0052 261 µM 1.97049395466831 0.026899704072162 no 152 0.0243908935747552 217 3562476
SGTC_2557 derrustone 83.84 µM 1.96840028163066 0.0270289356454895 no 153 0.0245109997630258 293 629853 An antioxidant.
SGTC_3228 9131799 49.47 µM 1.95847237944017 0.02764880762705 no 154 0.0250873044866493 195 17015818
SGTC_381 3461-2219 42.7 µM 1.94994924984508 0.0281903795316236 no 155 0.0255910841118611 236 2883159
SGTC_2247 cerulenin 830 nM 1.94207742443439 0.0286983831825 no 156 0.0260638640193033 226 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1455 4262-0120 131 µM 1.93939590213266 0.0288731625929261 no 157 0.026226574565629 257 1529587
SGTC_1888 azatryptophan 97.5 µM 1.93385704467828 0.0292369828889954 no 158 0.0265653533892664 189 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1441 4106-0040 13 µM 1.93351836700727 0.0292593519402905 no 159 0.0265861863470203 223 2904180
SGTC_2387 9077560 195.08 µM 1.9326062150117 0.029319668645032 no 160 0.0266423631149392 241 5303272
SGTC_43 0570-0105 72.5 µM 1.92537440061771 0.0298015413194283 no 161 0.0270912679109126 407 1114046 YDL195W SEC31
SGTC_2936 9038235 15.59 µM 1.92205580370535 0.0300248564533614 no 162 0.0272993682087792 248 4749415
SGTC_685 1278-0033 54.9 µM 1.91940045353949 0.030204538113412 no 163 0.0274668367967198 268 3590572
SGTC_3317 9138495 8.753 µM 1.91874871325073 0.0302487759030732 no 164 0.027508071657681 252 17020139
SGTC_2904 7225135 42.03 µM 1.91559989671675 0.0304632633694039 no 165 0.0277080213650999 210 4446116
SGTC_1237 0330-0133 46.1 µM 1.89979371388364 0.0315590506763836 no 166 0.0287300981004562 240 X1237 YHR072W ERG7
SGTC_2565 isoliquiritigenin 100 µM 1.89931309528174 0.0315928741102498 no 167 0.0287616610500535 222 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1950 st077106 7.18 µM 1.89482855451091 0.0319099189661029 no 168 0.0290575594536263 270 13831864
SGTC_1942 st076330 65.2 µM 1.89426191769005 0.0319501650011733 no 169 0.0290951265753847 259 24208414
SGTC_198 3454-2873 16.191 µM 1.88332639481979 0.0327351195220153 no 170 0.0298280742586445 247 710957
SGTC_170 4197-0004 226 µM 1.88073790535874 0.0329232309986494 no 171 0.0300037903252437 212 218692
SGTC_2283 7944793 200 µM 1.8804154851076 0.0329467242946811 no 172 0.030025737379912 286 2970533
SGTC_890 0929-0006 47.2 µM 1.87618569385012 0.0332562114790839 no 173 0.0303148929134923 216 1378169
SGTC_2733 amorolfine 100 µM 1.8746928455555 0.0333660109136391 no 174 0.0304174958604022 120 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3301 9125354 19.7965 µM 1.87362167635525 0.0334449795284792 no 175 0.030491294102309 216 41905162
SGTC_3184 9108758 49.47 µM 1.85868311823227 0.034562402965464 no 176 0.0315360338704271 207 902885
SGTC_276 colchicine 750 µM 1.85754144519618 0.0346490483275319 no 177 0.0316170802043881 271 2833 A microtubule depolymerizer.
SGTC_2070 5230947 200 µM 1.84235546018156 0.0358186237978821 no 178 0.0327115861468417 252 2835538
SGTC_1578 josamycin 24.2 µM 1.83482392439403 0.036410567965194 no 179 0.0332658912819023 256 5282165 A P450 substrate.
SGTC_471 1-acyl-paf 4 µM 1.82877274425409 0.0368919423759637 no 180 0.0337168298367447 276 16759367
SGTC_2773 thioridazine 9.09 µM 1.82542579906272 0.0371604206600063 no 181 0.0339683995169343 253 5452 An antipsychotic.
SGTC_2855 9016525 58.44 µM 1.82333477158971 0.0373289632108411 no 182 0.0341263514895887 277 43811474
SGTC_3151 9099821 49.47 µM 1.82222426834691 0.0374187263924419 no 183 0.034210481854615 254 17174189
SGTC_746 1095-0025 46.6 µM 1.81889011070265 0.0376892897037914 no 184 0.0344640984462036 281 6749286
SGTC_2147 5545932 89.7195 µM 1.81694023950327 0.0378482583436967 no 185 0.0346131321734601 246 797404
SGTC_298 1391-0729 10 µM 1.81398719257064 0.038090055136024 no 186 0.0348398487835175 242 3237558
SGTC_3148 9097893 49.47 µM 1.8119685403433 0.0382560672020379 no 187 0.034995528817461 304 17174100
SGTC_3019 9081971 49.47 µM 1.81087254357664 0.0383464477787605 no 188 0.0350802917989491 260 16451803
SGTC_2544 sphondin 68.51 µM 1.81024854451835 0.0383979831286516 no 189 0.0351286263003871 260 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_583 1488-1091 88.9 µM 1.79746386667076 0.0394663401825328 no 190 0.0361310047463074 346 4303273
SGTC_2681 menadione 3.18 µM 1.78205015686762 0.0407864116052182 no 191 0.0373705264179269 291 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1776 st049249 45.9 µM 1.77995878590302 0.040968251131431 no 192 0.0375413529301182 324 1822314
SGTC_1622 st003707 19.4 µM 1.7757729334943 0.0413341757053821 no 193 0.0378851753080632 357 10140899
SGTC_580 1123-0028 41 µM 1.77569913862136 0.0413406504925261 no 194 0.0378912597285718 363 1677248 YPR107C YTH1
SGTC_2956 9076196 2.52 µM 1.77329114844119 0.0415523798267523 no 195 0.0380902375179177 305 16423868
SGTC_1063 disulfiram 1.84 µM 1.77173008197644 0.041690109795084 no 196 0.0382196868105378 298 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1342 1486-1464 234 µM 1.77093853671281 0.0417600875022263 no 197 0.0382854615568293 284 3253938
SGTC_2736 butenafine 14.65 µM 1.76598400029849 0.0422002644183321 no 198 0.0386992665769068 338 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3221 9128209 49.47 µM 1.76042377816903 0.0426987153771307 no 199 0.0391679903118894 265 16460723
SGTC_462 ag-879 158 µM 1.75246268841338 0.043420668912187 no 200 0.039847140117888 339 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_711 k292-0785 179 µM 1.75225840580957 0.0434393232197177 no 201 0.0398646923666251 297 4146315
SGTC_332 4112-0506 40.9 µM 1.73930892853522 0.0446350852495342 no 202 0.0409902188264942 287 2790355
SGTC_2261 9010538 184.68 µM 1.73873759064572 0.044688447573733 no 203 0.0410404653484991 253 6457250
SGTC_1812 st052057 4.327 µM 1.72740741292593 0.045757325235112 no 204 0.0420472601247845 320 3645418
SGTC_1615 st002656 86.5 µM 1.72656823786725 0.0458373025991696 no 205 0.042122617167448 301 1584458
SGTC_1162 k048-0130 20.1 µM 1.72330703861892 0.0461491774994073 no 206 0.0424165077966389 309 6797406
SGTC_1004 4084-0029 199 µM 1.72266473708048 0.0462108024866517 no 207 0.0424745853471498 322 716894 YLR208W SEC13
SGTC_1731 st035964 63 µM 1.72146205323949 0.0463263705087886 no 208 0.0425835061772966 326 6739575
SGTC_1437 4092-1038 11.6 µM 1.72141610889752 0.046330789979559 no 209 0.0425876715923313 329 3977136
SGTC_3196 9111891 49.47 µM 1.71701656875018 0.0467555604346775 no 210 0.0429880723487919 273 18891510
SGTC_1770 st043884 66.3 µM 1.7134476490234 0.0471024257722615 no 211 0.0433151083091026 310 670149
SGTC_1765 st044815 90.4 µM 1.71073007728667 0.0473679292222949 no 212 0.0435654763352846 320 645695
SGTC_2880 9042983 58.44 µM 1.71058681921118 0.0473819585697534 no 213 0.0435787069445995 317 6464714
SGTC_3008 9078912 71.4286 µM 1.71026886075202 0.0474131083242092 no 214 0.0436080836057206 286 16648731
SGTC_1109 tnp00067 928.257 nM 1.70958192682317 0.0474804618860559 no 215 0.0436716050270402 284 676295
SGTC_574 1315-0397 40 µM 1.70412442129556 0.0480182953446153 no 216 0.0441789225388733 415 6794277
SGTC_778 3456-2434 196 µM 1.69923595813804 0.0485041797842721 no 217 0.0446373668707246 414 5539063
SGTC_1718 roemerine 11.9335 µM 1.69795818705025 0.0486318286851522 no 218 0.0447578269118346 385 235224 An aporphine alkaloid with mutagenic activity.
SGTC_680 0417-1641 114 µM 1.69638076454885 0.0487897829202155 no 219 0.0449068970636479 294 2835990
SGTC_308 4092-1169 104 µM 1.69227366451283 0.0492029688590941 no 220 0.0452969033655779 364 2268590 YDL196W YDL196W
SGTC_2054 5233173 129 µM 1.69131705837764 0.0492996062638675 no 221 0.0453881318803386 388 6889
SGTC_670 4204-0025 119 µM 1.69067788369324 0.049364260810334 no 222 0.0454491702735725 351 719039
SGTC_14 0354-0009 295 µM 1.68553870698154 0.0498865682661552 no 223 0.0459423417158735 337 1713507
SGTC_398 bronopol 33.3 µM 1.68004384860588 0.0504498906487299 no 224 0.0464743923289485 348 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_143 4032-1194 15.74 µM 1.67993895761594 0.0504606929668204 no 225 0.0464845965098654 434 1806963
SGTC_2062 5245942 200 µM 1.67502104259789 0.0509692421301504 no 226 0.0469650515534283 363 1376160
SGTC_704 1310-0270 142 µM 1.67354286452704 0.0511228916282976 no 227 0.0471102377707936 382 5718033
SGTC_136 0097-0015 404.482 µM 1.67332234895457 0.0511458447230628 no 228 0.0471319275564275 363 4861337
SGTC_3192 9110362 49.47 µM 1.67289913162116 0.0511899196745241 no 229 0.0471735773971021 321 16649480
SGTC_1258 0671-0043 57.1 µM 1.67265683105441 0.0512151670852245 no 230 0.0471974360594038 354 4298767
SGTC_259 usnic acid 108.925 µM 1.67258995192919 0.0512221375494196 no 231 0.0472040231637522 349 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2342 7990637 118.86 µM 1.67201950028963 0.0512816234449673 no 232 0.0472602384287872 370 2033102 YER133W GLC7
SGTC_1243 0416-0003 5.65 µM 1.66826655746506 0.0516743463331769 no 233 0.047631411782025 354 2141977
SGTC_904 1141-0088 396 µM 1.66703038701546 0.0518042263418676 no 234 0.0477541813785099 325 1378119
SGTC_1658 st012944 20 µM 1.66632104984075 0.051878870935491 no 235 0.0478247431491943 367 24207260
SGTC_3112 9123419 49.47 µM 1.66629287967174 0.0518818370874455 no 236 0.0478275471173099 368 17015854
SGTC_2019 4016004 108 µM 1.66625416858186 0.0518859133557791 no 237 0.0478314005095336 298 45595336
SGTC_2012 4023501 200 µM 1.66520297996242 0.0519967005811104 no 238 0.0479361333287532 322 3477460
SGTC_88 0180-0332 8.668 µM 1.66484095166547 0.0520348990700713 no 239 0.0479722456739927 351 3101745
SGTC_2203 7227154 166.4 µM 1.65570203274798 0.0530065738478008 no 240 0.0488910877300176 303 896304
SGTC_2817 7995342 71.43 µM 1.65434267323918 0.0531523261434254 no 241 0.0490289535681223 296 18879975
SGTC_2056 5235370 200 µM 1.65321993203458 0.0532729473589469 no 242 0.0491430556767915 367 5511916
SGTC_2084 5306078 60.6385 µM 1.65243454350393 0.0533574541383571 no 243 0.0492229992548182 345 679340
SGTC_3079 9117512 49.47 µM 1.65141608451236 0.0534671971666991 no 244 0.0493268213583255 265 7185044
SGTC_2154 5570129 200 µM 1.64632675828037 0.0540182747383455 no 245 0.0498482516358267 381 673366
SGTC_1970 st070122 35.8 µM 1.64136966471179 0.0545593469555869 no 246 0.0503603514790509 370 102928
SGTC_882 0843-0131 351 µM 1.63798488723926 0.0549312550985857 no 247 0.0507124232086376 369 5425421
SGTC_2021 4019055 173 µM 1.63239597217077 0.0555497286229173 no 248 0.0512980485509771 553 44827708 YER133W GLC7
SGTC_712 r015-0009 80.6 µM 1.62662013796642 0.0561946491529954 no 249 0.0519088998111495 320 6813872 YLR060W FRS1
SGTC_3116 9124943 49.47 µM 1.6248739581533 0.0563907827127135 no 250 0.0520947090705137 344 41905195 YPL160W CDC60
SGTC_706 4262-0057 46.9 µM 1.61629914385336 0.0573617602361013 no 251 0.0530148259274089 368 883298
SGTC_2442 5158906 48.48 µM 1.61447076523379 0.0575704902325748 no 252 0.0532126765408118 377 1893835
SGTC_1366 1683-0113 21.9 µM 1.61051385734015 0.0580242609614337 no 253 0.0536428613684298 339 708623
SGTC_2561 acetosyringone 100 µM 1.60889051204141 0.0582112343006941 no 254 0.0538201422503137 427 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3253 9135987 49.47 µM 1.6077533609863 0.0583424905334126 no 255 0.0539446033438792 313 4182430
SGTC_1879 gemcitabine 100 µM 1.60242154091893 0.0589610212311513 no 256 0.0545312122894345 359 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2593 nobiletin 86.24 µM 1.6002041245892 0.0592197678297486 no 257 0.0547766537268778 324 72344 An anti-infammatory.
SGTC_1820 st053765 18.6 µM 1.59569938944302 0.0597481591313671 no 258 0.055277962511918 348 3690829
SGTC_1036 k216-0215 33.5 µM 1.59358783469082 0.0599971059973396 no 259 0.0555141905102282 447 622330
SGTC_723 4182-0001 115 µM 1.59309433811282 0.0600554049160839 no 260 0.0555695146589141 355 744821 YLR208W SEC13
SGTC_926 2268-1401 59.4 µM 1.58890558853047 0.0605520280361111 no 261 0.0560408546504309 388 2931578
SGTC_843 0310-0051 143 µM 1.58654126719108 0.0608337600267239 no 262 0.0563082893115495 366 2065037
SGTC_1494 4358-1428 177 µM 1.58063919918179 0.0615415222686673 no 263 0.0569802788149138 392 1564571
SGTC_3109 9122853 49.47 µM 1.57826767445256 0.0618277146134104 no 264 0.0572520644394487 362 1234709
SGTC_553 k007-0256 45.7 µM 1.57577553693857 0.0621295806991834 no 265 0.0575387710241238 398 6287000
SGTC_1962 st076595 64.5 µM 1.57487693194861 0.0622387079734615 no 266 0.0576424271246193 402 279619
SGTC_3329 9141233 27.5565 µM 1.57282437773442 0.0624885324571069 no 267 0.0578797446559156 351 4909101 YNL103W MET4
SGTC_1836 st055642 81 µM 1.56747060544035 0.0631438407175774 no 268 0.0585023658740471 400 8571
SGTC_229 benomyl 22.8748 µM 1.55923206323897 0.0641626867891154 no 269 0.0594707322888516 421 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_190 3970-0790 3.722 µM 1.55629622093558 0.0645288299005057 no 270 0.0598188348300087 350 2832352
SGTC_1939 st074455 53.6 µM 1.55086819373602 0.0652100577255243 no 271 0.0604666370259989 413 1644229
SGTC_1317 1273-0028 910 nM 1.54998924052777 0.0653208910748298 no 272 0.0605720492463362 386 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2517 totarol 10 µM 1.54782987991974 0.0655938004292175 no 273 0.0608316302398918 367 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1705 st027868 56.3335 µM 1.5443000786058 0.0660418147478117 no 274 0.0612578267758366 351 292948
SGTC_1202 1988-0068 29.6 µM 1.54282078519443 0.0662302751637552 no 275 0.0614371324484016 406 2850480
SGTC_2279 7948423 32.93 µM 1.54175983038255 0.0663656959872101 no 276 0.061565983407719 345 1247112
SGTC_228 caffeine 993.056 µM 1.53955899038284 0.0666472959385034 no 277 0.0618339441321503 346 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2964 9083345 53.42 µM 1.53466140684766 0.0672772652290308 no 278 0.0624335101882713 370 17741579
SGTC_1381 2324-0066 62.1 µM 1.53316914670676 0.0674701247534499 no 279 0.0626170920492501 420 10885928
SGTC_2211 7117706 200 µM 1.53151392107614 0.0676845454140889 no 280 0.0628212142716113 365 822771
SGTC_2864 9034755 47.6 µM 1.52621054703429 0.068375099609239 no 281 0.0634787188171681 396 4930451
SGTC_3220 9131269 49.47 µM 1.52215070764058 0.0689073965782148 no 282 0.0639856614143878 360 17722206
SGTC_1180 1193-0155 285 µM 1.52020247472683 0.06916396650291 no 283 0.0642300478210309 407 2921347
SGTC_2560 caryophyllene 100 µM 1.51945731726399 0.0692622934001669 no 284 0.0643237119789273 459 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2646 retinol 96.75 µM 1.51923765446809 0.0692912994419398 no 285 0.0643513432102493 393 445354 A vitamin A analog and teratogen.
SGTC_2257 7960413 200 µM 1.51247474349104 0.0701889151712742 no 286 0.065206566528966 473 2974689 YIL048W NEO1
SGTC_3113 9123498 49.47 µM 1.51223452894658 0.0702209616489727 no 287 0.0652371049518143 384 8897275
SGTC_1550 gossypolone 36.6 µM 1.50853984204414 0.0707152802004914 no 288 0.0657082088050118 425 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_405 ebelactone b 50 µM 1.50648536893057 0.0709913061758076 no 289 0.0659713101406005 434 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2118 5526350 200 µM 1.49901818023991 0.072001523599923 no 290 0.0669344578674057 432 743594
SGTC_1817 st052116 64.4 µM 1.49275890819691 0.0728567859491616 no 291 0.0677501535840386 407 4361398
SGTC_1430 4049-0248 69.1 µM 1.48949095962153 0.0733063954447376 no 292 0.0681790660890003 473 22774488
SGTC_2801 7907800 81.82 µM 1.48529709680923 0.0738864995949997 no 293 0.0687325702989312 451 6620925
SGTC_507 nimesulide 162 µM 1.48523914997848 0.073894539425062 no 294 0.0687402422936303 433 4495 A COX2 inhibitor.
SGTC_1245 0418-0076 17.2 µM 1.48442932538061 0.074006968465377 no 295 0.0688475298659812 452 6790114
SGTC_1136 pergolide 1.05886 µM 1.47772931996835 0.0749421583592256 no 296 0.0697401216364875 530 47811 A dopamine receptor agonist.
SGTC_2664 lyso-paf C-16 73.48 µM 1.47033569696455 0.0759845965546123 no 297 0.0707354287750149 451 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2824 7998404 51.95 µM 1.46998729302002 0.076033989576541 no 298 0.0707825977623536 404 837851
SGTC_1665 st014639 11.4 µM 1.46962133394311 0.0760858976982087 no 299 0.070832169488248 491 981133 YIL048W NEO1
SGTC_1296 1068-0102 11.9 µM 1.46766642178144 0.076363642099895 no 300 0.0710974279750181 434 767053
SGTC_3332 9141069 11.198 µM 1.45889041959259 0.0776200062291496 no 301 0.0722976352044742 390 17332883
SGTC_1073 triclabendazole 3.09 µM 1.45733505058552 0.0778442992793508 no 302 0.0725119580080121 515 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2657 nystatin 74.44 µM 1.45662245074906 0.0779472243826001 no 303 0.0726103134596491 455 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_694 1315-0438 43.2 µM 1.45558655152084 0.0780970296908921 no 304 0.0727534739778759 383 6793154
SGTC_231 b-estradiol 524 µM 1.4520146735753 0.0786152476077343 no 305 0.0732487626258586 372 450 A steroid.
SGTC_1978 st071761 42 µM 1.45083870570697 0.0787864293117248 no 306 0.0734123894901907 414 5147680
SGTC_2400 5203494 178.7 µM 1.4484391267352 0.0791366038805343 no 307 0.073747139431705 424 6777674
SGTC_312 4092-0653 6.84 µM 1.44584611468901 0.0795163299723496 no 308 0.0741101842605896 561 1148278
SGTC_2556 citropten 84.59 µM 1.44448019471489 0.0797169117975969 no 309 0.0743019734378943 506 2775 A potential DNA crosslinker.
SGTC_643 k048-0106 28.4 µM 1.44000520948552 0.0803767331733532 no 310 0.0749329626034501 449 6763920
SGTC_3201 9113999 49.47 µM 1.43771546356006 0.0807159403703102 no 311 0.0752574018534158 461 16649224
SGTC_1667 st014849 34.6 µM 1.43746290472702 0.0807534209985396 no 312 0.0752932529574377 449 5348460
SGTC_457 grayanotoxin iii 135 µM 1.43484707721862 0.0811423923746369 no 313 0.0756653396843386 543 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_881 0833-0569 170 µM 1.4344131235544 0.0812070574215763 no 314 0.0757272023882552 470 5418700
SGTC_454 lyso-paf C-16 6.67 µM 1.43137447576721 0.081660947405593 no 315 0.0761614597857251 447 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1659 st012954 42.1 µM 1.42914467400844 0.0819952329747079 no 316 0.0764813277889356 435 24207262
SGTC_2129 girgensonine 121.053 µM 1.42681728845206 0.0823452466955745 no 317 0.0768162832924579 521 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1522 st012842 45.6 µM 1.42536046050748 0.0825649097536953 no 318 0.0770265156807205 425 3491067 YOR116C RPO31
SGTC_72 0744-0168 198.391 µM 1.42424643034469 0.0827331825537155 no 319 0.0771875743311849 453 677577
SGTC_409 arachidonic acid 100 µM 1.42346817804184 0.0828508895770744 no 320 0.077300240304152 471 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1156 4092-0367 4.88 µM 1.41934746966061 0.0834762279465189 no 321 0.0778988695507997 486 1357585
SGTC_1335 1486-0900 202 µM 1.41917767980798 0.083502070299769 no 322 0.0779236107503332 501 X1335
SGTC_2858 9025781 8.96 µM 1.41852642361787 0.0836012485458246 no 323 0.0780185648876887 599 4894980 YPL153C RAD53
SGTC_2805 7950783 58.44 µM 1.4174465590559 0.0837658935502831 no 324 0.0781762041980855 532 1178958 YDL195W SEC31
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.416067860182 0.0839764551315942 no 325 0.0783778185128495 532 65057 A dermal irritant. YDR527W RBA50
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.41058622643842 0.0848175692981566 no 326 0.079183327624133 500 688801
SGTC_1669 st015249 58.4 µM 1.40772962550053 0.0852583885116511 no 327 0.0796055729497895 436 722793
SGTC_477 mead ethanolamide 10 µM 1.40725359062742 0.0853320148610064 no 328 0.0796761028176047 283 16061185
SGTC_1761 st044296 37 µM 1.40546493173908 0.0856090850839043 no 329 0.0799415351142711 470 1826700
SGTC_26 0302-0163 425.158 µM 1.40293055959945 0.0860028218470426 no 330 0.0803187734888967 458 3100915
SGTC_429 1112-0049 25.5 µM 1.40092927814775 0.086314694570544 no 331 0.0806176112614389 453 2836170
SGTC_1905 st060207 84.5 µM 1.40066983305008 0.0863551874409255 no 332 0.0806564138469986 470 1948547
SGTC_1712 st032288 53.4 µM 1.39907194623546 0.0866048906939383 no 333 0.080895704661539 663 2883011
SGTC_2026 5148700 152 µM 1.39799906028951 0.0867728541665166 no 334 0.0810566746882455 494 79838
SGTC_2122 5258151 111.688 µM 1.39772011729164 0.0868165633636151 no 335 0.0810985653615153 476 2173356
SGTC_798 1287-0182 476 µM 1.39727934145367 0.0868856646206898 no 336 0.0811647928208161 519 1649755
SGTC_321 4534-3890 65.3 µM 1.39410838140572 0.0873839935611648 no 337 0.0816424392934233 472 699746
SGTC_9 0092-0002 10.449 µM 1.39167832905329 0.0877673275817041 no 338 0.0820099137568296 494 759368
SGTC_2355 9061122 103.12 µM 1.38998026120688 0.088035936671351 no 339 0.0822674356755425 457 5302957
SGTC_146 3448-8650 53.125 µM 1.38508380085754 0.0888139154608665 no 340 0.083013422298155 661 2891488 YIL048W NEO1
SGTC_3321 9137793 26.8275 µM 1.37970046869414 0.0896751466565716 no 341 0.0838394442773463 515 4904192
SGTC_2291 7917025 104.35 µM 1.37799945071165 0.0899485641387361 no 342 0.0841017288668729 518 2964612
SGTC_1167 k781-0610 148 µM 1.375597932248 0.0903356324087602 no 343 0.0844730736156196 528 4525169
SGTC_139 0099-0334 718.624 µM 1.3716329243785 0.090977403308047 no 344 0.0850888694642649 585 97690
SGTC_8 0354-0001 70 µM 1.36984860339394 0.0912673121296792 no 345 0.0853670832088102 612 4993152
SGTC_452 diindolylmethane 8 µM 1.36904808928178 0.091397598585995 no 346 0.0854921216556834 432 3071 Inhibits expression of several cancer promoting factors.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.36464953810594 0.0921159388264554 no 347 0.086181613462559 483 803109
SGTC_1 0258-0098 57.368 µM 1.36339709611929 0.0923212412994252 no 348 0.086378697895804 429 6790032 YDR047W HEM12
SGTC_698 k064-0052 127 µM 1.36146009868439 0.0926394238470996 no 349 0.0866841674449805 433 5088751
SGTC_2893 9048488 25.97 µM 1.36053439487631 0.092791771517106 no 350 0.0868304381525267 472 6467338
SGTC_2992 9074591 71.4286 µM 1.35605855603392 0.093530996610871 no 351 0.087540268914667 490 17741321
SGTC_635 k038-0028 24.7 µM 1.35484854300659 0.0937315859744695 no 352 0.0877329084519889 519 4035102
SGTC_1470 k295-0292 231 µM 1.35296700181437 0.0940441282297025 no 353 0.0880330862516589 532 5045612
SGTC_2365 9042475 200 µM 1.35081300167147 0.0944028718393383 no 354 0.088377671068347 532 6464479
SGTC_47 0149-0135 24.25 µM 1.34930585536896 0.0946544828630903 no 355 0.0886193728333806 476 5239155
SGTC_45 0kpi-0036 14.9 µM 1.34712627139919 0.095019228007804 no 356 0.0889697841482664 470 2795021
SGTC_1872 amphotericin b 148 nM 1.34339995081458 0.0956452100108093 no 357 0.0895712514084009 518 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_81 0411-0046 9.971 µM 1.34307827244792 0.0956993904838073 no 358 0.0896233151100108 475 12925265
SGTC_1280 0880-0253 10.1 µM 1.34304723301315 0.0957046196680581 no 359 0.0896283400382515 535 6836607
SGTC_550 4123-0385 25.7 µM 1.34244229845156 0.0958065743986642 no 360 0.0897263138303759 512 5731123
SGTC_2327 6189656 200 µM 1.3416267650142 0.0959441495647947 no 361 0.0898585217154025 488 5349088
SGTC_2235 salicylic acid 500 µM 1.3408505461902 0.0960752275089537 no 362 0.0899844906582614 489 338 A COX inhibitor and kinase inhibitor.
SGTC_3182 9108849 49.47 µM 1.33990742608317 0.0962346667342835 no 363 0.0901377217559989 547 17133045
SGTC_3057 9095946 49.47 µM 1.33774160734578 0.0966015453361981 no 364 0.0904903413424449 505 24540043
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.33636441030264 0.0968353692259528 no 365 0.0907150965265751 437 4620898
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.33578321538126 0.0969341705238652 no 366 0.0908100703256803 535 688798
SGTC_2706 st078239 82.5 µM 1.33559361138566 0.0969664186079509 no 367 0.0908410697105861 514 15434492
SGTC_604 1000-0114 314 µM 1.33515021641095 0.0970418625212299 no 368 0.0909135934075114 558 1572745
SGTC_1052 3253-3998 198 µM 1.33021658598937 0.0978842311890415 no 369 0.091723460474848 579 5450317
SGTC_1706 st031321 9.9705 µM 1.32753316838736 0.0983446423965382 no 370 0.0921661877561771 512 6103185
SGTC_1223 0764-0573 147 µM 1.32725094977647 0.0983931564754293 no 371 0.0922128417537542 568 1609797
SGTC_1827 berberine 7.24 µM 1.3236205449641 0.0990187954957716 no 372 0.092814549202581 478 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1848 st056003 16.4 µM 1.3230012562884 0.0991258093457432 no 373 0.0929174800245361 556 146492
SGTC_3141 9094609 49.47 µM 1.32214715266784 0.0992735382461014 no 374 0.0930595774260145 507 25236309 YDL196W YDL196W
SGTC_3070 9117005 49.47 µM 1.32065015062485 0.0995328534372088 no 375 0.0933090213377649 438 8779016
SGTC_1403 3909-7815 62.9 µM 1.32006614001052 0.0996341516290261 no 376 0.0934064682577445 468 6615483
SGTC_1610 st001799 48.1 µM 1.32002158524567 0.0996418828629671 no 377 0.0934139056677492 456 621897
SGTC_1291 0993-0025 5.79 µM 1.31696251476789 0.100173747783906 no 378 0.0939255949115728 531 4353356
SGTC_2268 7933382 153.85 µM 1.31564296469152 0.100403809898581 no 379 0.0941469528837933 612 935025 YOR257W CDC31
SGTC_463 ikarugamyin 104 µM 1.31325274602818 0.100821523213171 no 380 0.0945488978541096 440 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1573 oleylamine 1.06 µM 1.31300938970989 0.100864123003182 no 381 0.0945898920940519 544 5356789 An amine of the fatty acid oleic acid.
SGTC_2168 5727979 200 µM 1.30866558001029 0.101626720710101 no 382 0.0953238279452943 486 695210
SGTC_533 1222-0222 6.71 µM 1.30754277058173 0.101824521851746 no 383 0.0955142194454374 588 3982874
SGTC_1816 st051957 91.6 µM 1.30624394959311 0.102053679692744 no 384 0.0957348056545135 518 674121
SGTC_2159 5658611 73.75 µM 1.30522319647808 0.102234039720105 no 385 0.09590842884819 516 793844
SGTC_1932 st074806 40.9 µM 1.30506349640031 0.102262278583056 no 386 0.0959356136873028 595 17251235
SGTC_492 tmb-8 126 µM 1.30473484942088 0.102320409222651 no 387 0.0959915752294836 368 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.30262290760211 0.102694540180137 no 388 0.0963517665672987 536 6710655
SGTC_2190 6049624 200 µM 1.30139792656248 0.102912000919753 no 389 0.0965611415023069 464 2265554
SGTC_2591 skatole 100 µM 1.30030542540842 0.103106225669426 no 390 0.0967481546537742 526 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_371 0195-0006 7.36 µM 1.29897282027738 0.10334349632305 no 391 0.0969766284767484 466 3928593
SGTC_3041 9091929 49.47 µM 1.29732937018996 0.103636658544186 no 392 0.0972589414906766 566 25236887
SGTC_547 1120-0019 610 nM 1.29642329755498 0.103798543585279 no 393 0.0974148449322493 556 3676939
SGTC_566 0958-0068 16.5 µM 1.2952771364524 0.104003587125065 no 394 0.0976123217259296 492 6815365
SGTC_2326 6164455 177.58 µM 1.29057281741318 0.104848247290727 no 395 0.098425923396783 509 2888790
SGTC_970 1315-0089 19.5 µM 1.29022801908241 0.104910350607411 no 396 0.0984857502462543 527 6811083 YLR033W RSC58
SGTC_90 0870-0863 4.608 µM 1.28907614466659 0.105118013436552 no 397 0.0986858079969977 586 1738164
SGTC_2234 tolnaftate 200 µM 1.28850055314172 0.105221893927867 no 398 0.0987858882128234 466 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3273 9137859 49.47 µM 1.28787074484843 0.105335644331291 no 399 0.0988954803708694 505 2377234
SGTC_3095 9117207 49.47 µM 1.28659266070461 0.105566753973065 no 400 0.099118151573598 485 17015229
SGTC_212 3807-4682 38.772 µM 1.28617001629844 0.105643259290259 no 401 0.0991918664165484 720 3125501 YBL034C STU1
SGTC_2337 9009472 200 µM 1.28507868562242 0.105840992774848 no 402 0.0993823944893769 609 5742383
SGTC_1645 Cervolide 78 µM 1.28069269546914 0.106638369177433 no 403 0.100150813230856 511 23173 A fragrance.
SGTC_649 1123-0311 367 µM 1.27752327111471 0.107217265543189 no 404 0.100708785003979 616 693629 YIL048W NEO1
SGTC_2697 mebhydrolin 72.4 µM 1.27752034771896 0.107217800546288 no 405 0.100709300707294 626 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_106 0092-0003 11.579 µM 1.27464280895874 0.107745345304576 no 406 0.101217849007641 465 1072148
SGTC_1850 st056238 17 µM 1.26904455098304 0.108777037113025 no 407 0.102212587471975 630 5393177
SGTC_1898 st060199 18.6 µM 1.26660532107218 0.10922877281521 no 408 0.102648224434322 533 688866
SGTC_1209 2323-2347 50.3 µM 1.25974466565407 0.110506561981959 no 409 0.103880743483011 543 5412760
SGTC_849 0386-0493 241 µM 1.25829193316873 0.110778500959799 no 410 0.104143098736271 537 726119
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.25786795653157 0.110857956040983 no 411 0.104219756987682 599 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1188 1403-0014 4.57 µM 1.25727219340953 0.110969673643849 no 412 0.104327544668139 637 9614867
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.25652697726037 0.111109530198071 no 413 0.10446248564924 544 688803
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.25200398824428 0.111961078994369 no 414 0.105284205354531 612 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1367 1812-0510 76.9 µM 1.2514337197104 0.11206877454444 no 415 0.105388140675482 567 1142582 YDR527W RBA50
SGTC_2499 avocadenofuran 51.48 µM 1.25109128985816 0.112133478199768 no 416 0.105450586499639 580 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2902 5787006 60.46 µM 1.24689790484555 0.112928003569282 no 417 0.106217467538941 561 591003
SGTC_519 k048-0011 62.8 µM 1.2466654346519 0.112972167222032 no 418 0.106260098945273 577 6836379
SGTC_929 2805-0021 398 µM 1.23817487479645 0.114593621016121 no 419 0.10782561281331 566 3098024
SGTC_792 4534-1957 155 µM 1.23690291718799 0.114837947836876 no 420 0.108061563460184 586 1717904
SGTC_982 1491-0518 27.5 µM 1.22826802394662 0.116506400498672 no 421 0.109673185188865 546 3091256
SGTC_3331 9141060 1.957 µM 1.22480428219092 0.117180480556338 no 422 0.110324485580948 561 4906567 YPR165W RHO1
SGTC_2432 5630864 12.22 µM 1.22066103828214 0.117990422012911 no 423 0.111107192682996 597 5714970
SGTC_2024 5144227 134 µM 1.21878749424734 0.118357968811511 no 424 0.111462429627899 647 3475211
SGTC_999 SEC7.066 22.7 µM 1.21769965300863 0.118571749602456 no 425 0.111669064490065 640 740511 YDR170C SEC7
SGTC_3352 9151559 45.5865 µM 1.21621440842976 0.118864067832445 no 426 0.111951628198275 576 17159339
SGTC_3233 9132340 49.47 µM 1.21581771146986 0.118942229752653 no 427 0.112027185142863 585 17682950
SGTC_565 1418-0001 44.5 µM 1.21433356741291 0.119234975233836 no 428 0.112310186190114 650 2862145
SGTC_69 0096-0274 206.684 µM 1.21287254083045 0.119523657195832 no 429 0.112589277758103 681 6741392
SGTC_2206 7254556 146.969 µM 1.2124875605296 0.119599806862915 no 430 0.112662900736493 562 4398905
SGTC_2656 pseudo-anisatin 100 µM 1.21197754505883 0.119700741357685 no 431 0.112760488162279 569 6708809 A neurotoxin.
SGTC_2341 7987486 176.74 µM 1.2091145565584 0.120268455555843 no 432 0.113309418774245 641 1258686
SGTC_1886 st057356 49.9 µM 1.2084128114004 0.120407896583347 no 433 0.113444257166876 586 24207747
SGTC_2202 7226349 200 µM 1.20453851755298 0.121179792049063 no 434 0.114190751988063 577 844334
SGTC_1114 scopoletin 1.73284 µM 1.20449169987673 0.12118914100984 no 435 0.114199794110888 602 5280460 A coumarin with genotoxic properties.
SGTC_2367 9070478 135.38 µM 1.2024458213193 0.121598175376264 no 436 0.114595422597101 643 572802
SGTC_2942 9052777 62.25 µM 1.19738914124233 0.122613322035722 no 437 0.11557745704798 681 6469503
SGTC_541 4513-1321 94 µM 1.19666022203678 0.122760144040748 no 438 0.115719508641871 612 747515
SGTC_2290 7904846 200 µM 1.19651298624787 0.122789815861933 no 439 0.115748216963257 625 2962154
SGTC_2312 7706453 155.7 µM 1.19640707235539 0.12281116336198 no 440 0.115768871388522 617 976098
SGTC_2246 7293507 91.5585 µM 1.19567070697862 0.122959653615522 no 441 0.115912543456248 645 887656
SGTC_1097 itavastatin 7.23 µM 1.19221619786002 0.123657945836868 no 442 0.11658824186942 643 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1697 st025554 27.742 µM 1.18983610252123 0.124140669508201 no 443 0.117055408378469 590 1269519
SGTC_1992 st073643 23.3 µM 1.18884004265142 0.124343078131052 no 444 0.117251308770183 603 3161292
SGTC_2258 7960471 200 µM 1.18805884269812 0.124501986632706 no 445 0.117405113925728 520 2974708
SGTC_3135 9127742 49.47 µM 1.18630814835109 0.124858621210974 no 446 0.117750314958501 586 3643468
SGTC_826 1683-5028 118 µM 1.18562581354275 0.124997813006946 no 447 0.11788505173797 620 722377
SGTC_1614 st002383 48.6 µM 1.18558952329149 0.125005219013106 no 448 0.117892220821597 647 1947235
SGTC_875 0709-0210 25.7 µM 1.18510429621028 0.125104272155674 no 449 0.117988106325557 670 6251364
SGTC_1631 benzylvanillin 81.9 µM 1.18370598738913 0.125390026256121 no 450 0.118264734017626 649 75506
SGTC_2172 5754775 163.918 µM 1.18316703347097 0.125500286776013 no 451 0.11837147770938 584 2263357
SGTC_1557 sumaresinolic acid 42.3 µM 1.18257960944542 0.125620540476538 no 452 0.118487898804061 592 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_217 ketoconazole 989 nM 1.18053195501315 0.126040351717651 no 453 0.118894354421327 615 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2194 5927483 104.545 µM 1.17967747683407 0.126215826239517 no 454 0.119064257623215 675 760979
SGTC_2620 irigenin 100 µM 1.1773133623294 0.126702204697271 no 455 0.119535227739464 647 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2131 toluylene red 5.2905 µM 1.17442537384503 0.127298130870463 no 456 0.120112343416748 634 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1227 3909-8010 46.6 µM 1.17288613673091 0.127616542257111 no 457 0.120420734824422 622 15982272
SGTC_966 1300-0360 30.2 µM 1.17181555002026 0.127838333385618 no 458 0.120635559093241 645 70588
SGTC_2675 theaflavin digallate 100 µM 1.17171982336582 0.127858177907795 no 459 0.120654780767147 661 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1241 0364-0022 50.8 µM 1.16555271887288 0.129141156989005 no 460 0.12189766679732 672 4563895
SGTC_3350 9150499 3.57 µM 1.16349998836606 0.129570171697542 no 461 0.122313351420586 706 4910996 YPR165W RHO1
SGTC_2735 sertaconazole 140 nM 1.16325874796223 0.129620654997948 no 462 0.122362268648967 587 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_115 0527-0192 112.043 µM 1.16300810566888 0.129673120219362 no 463 0.122413106876396 746 4233931
SGTC_1166 k206-0078 225 µM 1.16152878483896 0.129983075814794 no 464 0.122713462111784 681 5404595
SGTC_1346 1488-2224 62.4 µM 1.16053894418836 0.130190758943012 no 465 0.122914723727989 683 3722427
SGTC_2201 6605497 169.863 µM 1.15849624859737 0.130620072069998 no 466 0.123330790842933 631 670741
SGTC_1075 aripiprazole 15.2 µM 1.15815161528602 0.130692600009893 no 467 0.123401084761554 702 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3203 9113543 49.47 µM 1.15712697789194 0.130908398947435 no 468 0.123610243019041 626 17018012
SGTC_2331 7980721 200 µM 1.15537119434154 0.131278756844477 no 469 0.123969226380041 666 2981221
SGTC_1149 3909-7961 23.3 µM 1.15227339583044 0.131933957137335 no 470 0.124604372851133 645 735261
SGTC_2658 polymyxin b sulfate 77.05 µM 1.15187980658087 0.132017364494488 no 471 0.124685233644285 687 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2907 7721985 69.9 µM 1.15035622322342 0.132340577038444 no 472 0.124998591381248 633 3267881
SGTC_2516 gossypol 71.55 µM 1.14312151382122 0.133882787330656 no 473 0.126494071539282 707 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1709 st033179 39.1045 µM 1.14113569189171 0.134308253385911 no 474 0.126906730223903 691 573381
SGTC_676 falcarinol 140 µM 1.14059534356651 0.134424184550573 no 475 0.127019177941814 687 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_51 1013-0126 23.419 µM 1.13929699834789 0.134703023968007 no 476 0.127289649967357 638 1627850
SGTC_2764 methyldopa 94.69 µM 1.1389033863043 0.134787636502646 no 477 0.127371726538658 709 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1767 st044992 70.3 µM 1.13787603534853 0.13500865205217 no 478 0.127586124687192 656 9600693
SGTC_1740 st038286 13.222 µM 1.13444141566987 0.135749350804864 no 479 0.128304717421731 669 716786
SGTC_295 k015-0027 31 µM 1.13254460936131 0.136159600612648 no 480 0.128702770422996 674 3887424
SGTC_1016 4226-1401 38 µM 1.12731349244121 0.137295403723365 no 481 0.129804979885812 696 2901613
SGTC_2868 9035608 32.47 µM 1.12609347443192 0.137561227260392 no 482 0.130062977932273 669 6462614
SGTC_370 0180-0345 38.7 µM 1.12562581835974 0.137663215553925 no 483 0.130161967516503 613 3989527
SGTC_662 k832-1615 104 µM 1.12266596024827 0.138309909972579 no 484 0.13078969503445 677 5878478
SGTC_1985 st071382 65.5 µM 1.12079157156788 0.138720511283607 no 485 0.131188296323049 681 6123237
SGTC_3258 9138477 49.47 µM 1.11989819468086 0.138916505222024 no 486 0.131378573851884 684 4970355
SGTC_1671 st016596 74.5 µM 1.11959217098085 0.138983685720148 no 487 0.131443796670112 729 2829167
SGTC_1181 1222-0449 220 µM 1.11747729532115 0.139448562839518 no 488 0.131895151069546 710 658318
SGTC_863 0466-0191 129 µM 1.11665005655286 0.13963068810464 no 489 0.132071989981345 737 765160 YPR165W RHO1
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.11538101327142 0.139910395513467 no 490 0.132343591155845 740 4174840
SGTC_2521 angolensin 13.4 µM 1.11151466684722 0.140764915781773 no 491 0.133173440219753 656 821428 A flavenoid.
SGTC_2790 5423970 71.43 µM 1.11038207134834 0.141015905537857 no 492 0.13341721030791 743 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2399 5884133 200 µM 1.10685794696359 0.141798812655076 no 493 0.134177675017092 674 722445
SGTC_816 0325-0417 81.3 µM 1.10572187960589 0.142051823634548 no 494 0.134423458422923 672 68101
SGTC_1030 k029-0042 36.7 µM 1.10415861041027 0.142400475048131 no 495 0.134762170210775 745 6080581
SGTC_1501 4491-0275 38.4 µM 1.10148977863643 0.142997033603033 no 496 0.135341775332297 708 5104718
SGTC_1499 4480-0877 67.3 µM 1.09965569446448 0.143407980381457 no 497 0.135741082861236 663 2861909
SGTC_2482 5981709 142.65 µM 1.09871572622583 0.14361889937599 no 498 0.135946040424156 728 877755
SGTC_221 trifluoperazine 10.304 µM 1.09841901308754 0.143685522139717 no 499 0.136010781906327 839 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_955 1216-0110 33 µM 1.09794055068185 0.143792998071104 no 500 0.136115224720923 723 3619719
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.0974431653597 0.143904782100301 no 501 0.136223856368927 723 2333 A French combination drug.
SGTC_79 0052-0007 94.094 µM 1.09724524014648 0.143949280769992 no 502 0.136267100804411 722 2801472
SGTC_150 3970-0969 77.2 µM 1.09632038055834 0.144157335951704 no 503 0.136469296726136 778 6615640
SGTC_1674 st016616 23.6 µM 1.09597318127067 0.144235493758588 no 504 0.136545255558667 698 625830
SGTC_516 3992-2719 87.3 µM 1.09500476421011 0.144453644431131 no 505 0.136757274638979 651 5350887 YDR037W KRS1
SGTC_1017 4239-0030 168 µM 1.09418014650975 0.144639577287091 no 506 0.136937988524242 728 1149593
SGTC_15 0266-0086 27.098 µM 1.09344423435343 0.144805645099947 no 507 0.137099400455404 813 1712902 YIL048W NEO1
SGTC_1290 0986-0249 10.2 µM 1.08946876353674 0.145704979728477 no 508 0.137973611147203 654 53329
SGTC_1695 st026914 34.495 µM 1.08693039493096 0.146281171865501 no 509 0.138533786142543 723 3289191
SGTC_1310 1188-0297 994 nM 1.08507661855448 0.146702931775377 no 510 0.138943861034456 716 1588352
SGTC_1685 st024049 53.0905 µM 1.08503395308466 0.146712648359187 no 511 0.138953308806053 694 1941139
SGTC_3129 9127257 49.47 µM 1.08381266264887 0.146990966695473 no 512 0.13922393481728 618 837894
SGTC_885 0865-0106 16.8 µM 1.08119606999906 0.147588449933925 no 513 0.139804952911304 713 2793380
SGTC_2779 methotrexate 400 µM 1.07950582302833 0.147975271376999 no 514 0.140181149683438 761 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1436 4092-1007 8.32 µM 1.0792116121857 0.148042672274477 no 515 0.140246702128409 703 2881121
SGTC_2505 galangin 7.89 µM 1.07887242879869 0.148120401447264 no 516 0.140322300636773 641 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_219 mitoxanthrone 164.414 µM 1.07837324610542 0.148234846625229 no 517 0.140433610737148 694 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2986 9022445 71.43 µM 1.0765051033419 0.148663671462099 no 518 0.140850709879219 729 6459286
SGTC_691 1548-0686 185 µM 1.07442366494785 0.149142433253002 no 519 0.141316420354603 738 46495133
SGTC_538 2922-0838 53.3 µM 1.07298086764047 0.149474901723296 no 520 0.141639850217887 801 777039
SGTC_2390 9097792 176.6 µM 1.07158134356699 0.149797870890997 no 521 0.141954058349104 693 4497149
SGTC_3078 9116413 49.47 µM 1.07024299014029 0.150107158759994 no 522 0.142254974119953 675 17177322
SGTC_1013 4112-3890 241 µM 1.06809326785192 0.150604841040109 no 523 0.14273922116246 742 705171
SGTC_1868 st057644 42.7 µM 1.0671808661315 0.150816403012933 no 524 0.142945085499595 778 688665
SGTC_1676 st018489 23.4 µM 1.06716949173151 0.150819041685277 no 525 0.142947653160294 733 3696235
SGTC_1514 1189-1591 158 µM 1.06643894391781 0.150988581053321 no 526 0.143112632546287 761 767698 YMR146C TIF34
SGTC_2027 5150920 200 µM 1.06462805183607 0.15140938427726 no 527 0.143522140175397 735 786715
SGTC_1028 k015-0029 4.8 µM 1.0626009353212 0.151881356558718 no 528 0.143981481343705 732 4588309
SGTC_336 4111-0029 111 µM 1.06131969718064 0.152180170040708 no 529 0.144272318585914 681 3131175
SGTC_729 4092-0585 94.1 µM 1.06126325831485 0.152193341820712 no 530 0.144285139140339 683 2169061
SGTC_89 0302-0250 142.109 µM 1.0594899309113 0.152607588953924 no 531 0.144688356258532 795 4203518 YLR208W SEC13
SGTC_3147 9097027 49.47 µM 1.057819772788 0.152998419269773 no 532 0.14506880825821 788 25236841
SGTC_819 1013-0258 27.7 µM 1.05769022807759 0.153028761470267 no 533 0.145098345878712 739 5753198
SGTC_3016 9080866 49.47 µM 1.05494844304941 0.153671883009179 no 534 0.145724452508133 765 17066299
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.04320531019737 0.156446607218456 no 535 0.148426607310511 751 390807
SGTC_1418 3966-3099 2.4 µM 1.04246113055147 0.156623550347176 no 536 0.148598968699488 775 740335
SGTC_3005 9076496 71.4286 µM 1.04040461697416 0.157113211097535 no 537 0.149075978795455 739 21368410
SGTC_1255 0566-0045 221 µM 1.0393002717634 0.157376573343566 no 538 0.149332554248883 767 2788469
SGTC_2237 6667747 47.222 µM 1.03690922765896 0.157947778944538 no 539 0.149889081513711 731 729940 YDL015C TSC13
SGTC_2766 oltipraz 83.91 µM 1.03598618541297 0.158168651738311 no 540 0.150104293720354 731 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1415 3966-0071 78.1 µM 1.03587480104249 0.158195318364699 no 541 0.150130277500172 765 2893185
SGTC_1725 st036284 20.55 µM 1.03554769383512 0.158273648432821 no 542 0.150206602500395 838 707914
SGTC_1314 1222-0010 41.1 µM 1.03433529154558 0.158564195838246 no 543 0.150489721855472 769 3526027
SGTC_1230 0170-0365 3.77 µM 1.03141820768446 0.159264695753876 no 544 0.151172373040532 904 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1778 st046819 58.9 µM 1.03122924099027 0.159310143447936 no 545 0.151216665654387 817 671715
SGTC_2071 5230951 39.92 µM 1.03099840981384 0.159365671338753 no 546 0.151270782754093 809 1799272
SGTC_1833 st055984 71 µM 1.03076149730478 0.159422675308542 no 547 0.151326338982955 762 676288
SGTC_3111 9122088 49.47 µM 1.030220858986 0.159552809307226 no 548 0.151453170040673 653 16876704
SGTC_2800 7887935 81.82 µM 1.02867772860532 0.159924629845869 no 549 0.151815569432304 735 2961002
SGTC_3249 9135183 49.47 µM 1.02743095540912 0.160225456074667 no 550 0.152108790744319 809 4902779
SGTC_869 0564-0080 44.1 µM 1.02421837035235 0.16100230428579 no 551 0.152866071887295 770 6843321
SGTC_3028 9087778 49.47 µM 1.02306727718061 0.161281251997148 no 552 0.153138018700658 787 17217395
SGTC_1511 0906-3109 28.5 µM 1.02254624540228 0.161407618704317 no 553 0.153261218283691 858 2882180
SGTC_917 harmaline 728.087 nM 1.02193092437839 0.16155693666928 no 554 0.153406797404868 771 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3316 9136639 10.545 µM 1.02118078630208 0.161739092026769 no 555 0.153584396826922 781 4903665
SGTC_642 0335-0876 158 µM 1.01912062523235 0.162240047391753 no 556 0.154072851749827 785 6812350
SGTC_660 4031-1742 102 µM 1.01628000595007 0.162932436396102 no 557 0.154748033475022 804 6738706
SGTC_1480 1070-0044 41.2 µM 1.01395750549649 0.163499961502543 no 558 0.155301514846392 794 3124987
SGTC_1534 6-azauridine 81.6 µM 1.01078309279414 0.164277733448543 no 559 0.156060128467386 842 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1325 1431-0015 227 µM 1.00769496770761 0.165036662142169 no 560 0.15680046079866 747 1103340
SGTC_2687 chenodiol 100 µM 1.00615028833172 0.16541712842183 no 561 0.157171640576959 738 5702181 A cholesterol synthesis inhibitor.
SGTC_3302 9125395 16.351 µM 1.00543584644084 0.165593292662199 no 562 0.157343513139295 774 17599668
SGTC_1218 1348-1416 30.7 µM 1.00474001008947 0.16576498581188 no 563 0.157511028508008 778 6787668
SGTC_294 k038-0071 157 µM 1.00286711269759 0.166227682759066 no 564 0.157962491133617 794 24152826
SGTC_654 1124-0271 80.9 µM 1.00156632481935 0.166549531175434 no 565 0.158276546002239 806 5403748
SGTC_459 nigericin 15.3 µM 1.00063437925404 0.166780365664151 no 566 0.158501801412725 836 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2952 9073731 13.78 µM 0.999698681633051 0.16701233706477 no 567 0.158728175139613 839 16457353
SGTC_530 4358-1714 28 µM 0.998031622297028 0.167426137691854 no 568 0.15913201246916 850 1564641
SGTC_1784 st039334 36.3 µM 0.995553413207883 0.168042503339305 no 569 0.1597335898901 783 3496984
SGTC_1681 tripelennamine 100 µM 0.992492323482628 0.16880585282647 no 570 0.160478711158613 751 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1862 st057513 3.81 µM 0.991604453378286 0.169027678810162 no 571 0.160695258007729 801 5393163
SGTC_1062 mesoridazine 14.2 µM 0.990750132479074 0.169241299500641 no 572 0.160903802442859 823 4078 A neuroleptic.
SGTC_2850 9015429 58.44 µM 0.989659525146226 0.169514254734481 no 573 0.161170282303382 755 6457570
SGTC_2885 9057732 51.95 µM 0.986235774985505 0.170372978804452 no 574 0.162008713852474 794 6471414
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.985855747486693 0.170468466483444 no 575 0.162101952467518 806 616764
SGTC_2807 7945238 51.95 µM 0.98512954683991 0.170651030721069 no 576 0.162280220806409 811 17148797
SGTC_1105 epirubicin 18.1 µM 0.98003432400246 0.171935469424948 no 577 0.163534587980611 796 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_681 1642-0006 26.6 µM 0.978691141902499 0.172275093401835 no 578 0.163866305101975 814 4446530
SGTC_2376 9072922 81.32 µM 0.978512373324561 0.172320327341396 no 579 0.163910487340961 842 17087968
SGTC_2418 pentamidine 31.67 µM 0.977668506466362 0.172533953861159 no 580 0.164119151432691 761 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2932 9016711 44.54 µM 0.976296636531255 0.172881605656869 no 581 0.164458743126378 864 7117328
SGTC_1881 5652484 16 µM 0.973196731763549 0.173668809276073 no 582 0.165227767425701 796 2255129
SGTC_1438 4092-1045 4 µM 0.973151314652074 0.173680359624502 no 583 0.165239051772946 835 1351342
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.972335935638187 0.173887807601136 no 584 0.165441725906949 803 364106
SGTC_1009 4106-0057 9.87 µM 0.971498922249096 0.174100923603104 no 585 0.165649944777291 890 2928005
SGTC_2061 5245884 80.95 µM 0.97149318804459 0.174102384188851 no 586 0.165651371825622 833 573863
SGTC_1617 st002906 78 µM 0.971255762832614 0.174162866700211 no 587 0.165710465858798 854 5150859
SGTC_1051 3253-3903 78 µM 0.971171259994876 0.17418439646433 no 588 0.165731501511395 862 5509239
SGTC_2212 7123476 200 µM 0.969253896783809 0.174673359789988 no 589 0.166209262903301 759 1085715
SGTC_1937 st074714 47.2 µM 0.968549570010075 0.174853194883383 no 590 0.16638498760873 811 17250970
SGTC_900 1112-0045 141 µM 0.967361240616079 0.175156876185069 no 591 0.166681739485805 720 56211 YIL048W NEO1
SGTC_2306 7482397 179.52 µM 0.962022056960058 0.176525446074574 no 592 0.168019262175174 823 891448
SGTC_3271 9137798 49.47 µM 0.961617519992608 0.176629414196446 no 593 0.168120883757428 768 6498326
SGTC_1419 3993-2473 62.6 µM 0.959605836222235 0.177147002342818 no 594 0.168626815317213 860 704026
SGTC_3051 9093778 49.47 µM 0.95935336932224 0.1772120274027 no 595 0.168690378922556 802 17217378
SGTC_977 1348-1378 135 µM 0.958577216305328 0.177412026800968 no 596 0.168885887438023 894 X977
SGTC_506 n9-isopropylolomoucine 153 µM 0.95810886626861 0.177532780322574 no 597 0.169003932535294 860 6610355
SGTC_1814 st052110 31.539 µM 0.958060838252083 0.177545166198157 no 598 0.169016040732678 834 674163
SGTC_2289 7946404 165.07 µM 0.956998268655433 0.177819330228467 no 599 0.169284064441244 886 1246120 YPR165W RHO1
SGTC_3298 9116858 71.43 µM 0.956728978005706 0.177888854950514 no 600 0.169352033919027 862 2506942
SGTC_311 1315-0136 58 µM 0.955358906094407 0.178242841807993 no 601 0.169698113917554 850 6759207
SGTC_796 1234-0020 70.7 µM 0.951667150279973 0.179198892337691 no 602 0.170632907111704 814 46495034
SGTC_2836 9010338 19.48 µM 0.950447996099897 0.179515322685259 no 603 0.170942333062556 795 2994051
SGTC_193 1273-0060 1.558 µM 0.949561737099099 0.179745570707326 no 604 0.171167494146383 741 2847393 YHR072W ERG7
SGTC_2487 5918373 44.05 µM 0.949098011044224 0.17986611955913 no 605 0.171285382950229 910 2876279
SGTC_2028 5153890 36.43 µM 0.948770067187051 0.179951401519303 no 606 0.17136878442461 830 2830968 YPR165W RHO1
SGTC_3241 9133421 49.47 µM 0.948541980068603 0.180010730655373 no 607 0.171426806003746 867 17018221
SGTC_1941 st076221 61.8 µM 0.947078150654094 0.180391788580551 no 608 0.171799478745026 893 2828568
SGTC_504 lovastatin 124 µM 0.945953445271377 0.180684910702625 no 609 0.172086165961024 798 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.943294170422756 0.181379161261738 no 610 0.172765228424863 837 279621
SGTC_785 1270-0111 65.3 µM 0.943052267311604 0.181442397098465 no 611 0.172827084535087 877 6741994
SGTC_1492 4158-0558 28.5 µM 0.941826748585009 0.181762971700802 no 612 0.173140674042797 860 3967268
SGTC_184 1494-0393 24.714 µM 0.937657714105232 0.182856170078315 no 613 0.174210170696657 852 3090647
SGTC_962 1254-0300 21.5 µM 0.936725751222905 0.183101108157881 no 614 0.174449823273618 866 7340576
SGTC_2702 st077768 96.8 µM 0.935544881523477 0.183411757639272 no 615 0.174753782410351 775 6484119
SGTC_2460 5552655 174.22 µM 0.935415372396411 0.183445847378152 no 616 0.174787138864811 836 5401989
SGTC_2690 usnic acid 100 µM 0.935347349931007 0.183463754015431 no 617 0.174804660393674 928 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2150 5556613 200 µM 0.934309443475202 0.183737113799133 no 618 0.175072147224752 900 743190
SGTC_1198 1612-1005 86.7 µM 0.93272980251768 0.184153640199766 no 619 0.17547974664064 901 6998509
SGTC_27 0485-0001 32.618 µM 0.929735236624846 0.184944871636762 no 620 0.176254092771021 812 2054479
SGTC_491 tetrandrine 80.3 µM 0.929450092338119 0.185020323144109 no 621 0.176327939043005 852 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_546 peri-Naphthalide 147 µM 0.92915876618769 0.185097430170817 no 622 0.176403406500486 871 223824 A penicillin ester.
SGTC_309 k408-0051 1.48 µM 0.929023118100428 0.185133339767785 no 623 0.176438552837959 918 3640463
SGTC_2047 4141938 200 µM 0.928942861746607 0.185154587761318 no 624 0.176459349296364 821 3807862
SGTC_149 3970-0822 46.1 µM 0.928087804991284 0.185381059381235 no 625 0.176681012459768 986 3114250 YBL034C STU1
SGTC_293 4049-0273 38.5 µM 0.925808516518348 0.185985594873586 no 626 0.177272750235249 832 1380311
SGTC_2478 5763493 32.33 µM 0.923132664617566 0.186696868664546 no 627 0.177969036978715 894 1365576 YLR208W SEC13
SGTC_1484 3473-2379 286 µM 0.922658400252759 0.186823109322444 no 628 0.178092625575456 1059 671917
SGTC_281 1672-3440 14.9 µM 0.922365352177461 0.186901139858716 no 629 0.178169018040059 933 6833000
SGTC_316 k060-0003 58.6 µM 0.921009123753608 0.187262528272972 no 630 0.178522831803042 867 6152314
SGTC_3296 9122258 64.045 µM 0.918684980754581 0.187882836572642 no 631 0.179130183958377 880 4730474
SGTC_2785 7756463 72.73 µM 0.916586578388905 0.1884439838019 no 632 0.17967966006 903 2201551
SGTC_3263 9137018 49.47 µM 0.914289570385622 0.189059425083857 no 633 0.180282354710214 848 43844957
SGTC_3356 9151811 4.48 µM 0.91341481716252 0.189294124340517 no 634 0.18051220779921 879 1859254 YPR165W RHO1
SGTC_3288 9119690 36.221 µM 0.913020677767154 0.189399931866083 no 635 0.180615833231037 821 17595618 YKL019W RAM2
SGTC_714 4296-0578 26.1 µM 0.911625583529451 0.189774740120485 no 636 0.180982925030563 887 1589775
SGTC_1987 st072290 61.9 µM 0.910189010620941 0.190161168415479 no 637 0.181361419337491 929 54697379
SGTC_1803 st050068 52.4 µM 0.909860613403284 0.190249572871663 no 638 0.18144801180157 1023 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2908 7930301 100 µM 0.906327927945424 0.191202166941302 no 639 0.182381153802081 951 2223178
SGTC_2193 5925765 200 µM 0.904222576268399 0.191771266383094 no 640 0.182938695665616 897 877370
SGTC_248 streptozotocin 5.23457 mM 0.903603662058255 0.191938762686779 no 641 0.183102799385983 948 5300 DNA alkylating agent.
SGTC_2833 9001315 45.46 µM 0.901900348712819 0.192400191261291 no 642 0.183554903056325 885 2989378
SGTC_2407 paclitaxel 400 µM 0.901168686010727 0.192598607195914 no 643 0.183749318792839 914 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1835 st008666 49.2 µM 0.900821870869017 0.19269270192753 no 644 0.183841518515739 807 690455
SGTC_592 k241-0073 46.5 µM 0.899019683988834 0.193182106994385 no 645 0.184321088040511 961 4230158
SGTC_220 paclitaxel 373.376 µM 0.898052151341656 0.193445164611279 no 646 0.184578873382239 841 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2979 9012552 45.46 µM 0.896564138322822 0.193850159273972 no 647 0.184975770643722 873 17100905
SGTC_793 0488-0545 106 µM 0.895800939727459 0.194058080505811 no 648 0.185179543957712 896 292548
SGTC_166 k072-0058 166.424 µM 0.895239014396001 0.194211254872909 no 649 0.185329666577953 962 5846229
SGTC_2459 5811157 9.22 µM 0.894325481641491 0.194460430478497 no 650 0.185573885014219 951 2870684 YBR192W RIM2
SGTC_2241 6772625 37.8075 µM 0.893501785390482 0.194685268992269 no 651 0.185794258220999 894 2285411
SGTC_2713 st079149 53.4 µM 0.893350561658447 0.194726564637476 no 652 0.185834734524825 912 3103253
SGTC_2339 9000433 200 µM 0.892878780203596 0.194855431299332 no 653 0.185961045941197 825 2988954
SGTC_1570 verbenone 133 µM 0.890901274321768 0.195396149269605 no 654 0.186491068302671 948 29025 A natural terpanoid with antifungal properties.
SGTC_1915 st067105 30.6 µM 0.890429156121755 0.195525377240199 no 655 0.186617746321208 908 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_709 3807-1509 243 µM 0.889767834318773 0.195706481176519 no 656 0.186795280715611 936 1886677 YPL242C IQG1
SGTC_3134 9127454 49.47 µM 0.887428325819188 0.196347975823664 no 657 0.187424169412299 962 24262820
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.883255964136307 0.197495198840696 no 658 0.18854899521257 1018 91467 include heat shock
SGTC_557 1315-0110 16.2 µM 0.882737962672012 0.197637909608431 no 659 0.188688932967307 978 6833801
SGTC_536 3852-0578 10.6 µM 0.881804090750024 0.197895351211104 no 660 0.188941379551046 960 2869208
SGTC_493 zm226600 134 µM 0.880761836263724 0.198182909843832 no 661 0.189223369956457 936 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2670 beta-carotene 100 µM 0.876994046824047 0.199224547577979 no 662 0.190244935797118 892 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_582 0987-0078 156 µM 0.876473402499375 0.199368743028146 no 663 0.190386364762932 1056 1625765
SGTC_2705 st078069 42.8 µM 0.874597383856232 0.199888838129226 no 664 0.190896505879928 877 1530061
SGTC_1625 st003711 30.1 µM 0.869505087601044 0.201304700550727 no 665 0.192285463272827 955 24207034 YER133W GLC7
SGTC_1150 3909-7983 10.9 µM 0.868105936149205 0.201694771068872 no 666 0.192668170839512 939 23965914
SGTC_2340 7987427 183.45 µM 0.86809373806782 0.201698173770829 no 667 0.192671509405865 891 2239331
SGTC_2739 tacrine 100.86 µM 0.867597305523984 0.201836684719419 no 668 0.192807411013453 924 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.863491358265656 0.202984477827096 no 669 0.193933684370892 966 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2570 licareol 100 µM 0.862430888161634 0.203281558113089 no 670 0.194225224624605 883 443158
SGTC_1575 cyproterone acetate 48 µM 0.86210494180301 0.203372920892416 no 671 0.194314886110468 918 9880 An androgen receptor antagonist and liver toxin.
SGTC_657 3534-0529 86.7 µM 0.861888941482332 0.203433479287678 no 672 0.194374317468192 976 1049549
SGTC_2081 5214970 32.255 µM 0.861322969769319 0.203592207561585 no 673 0.194530094102824 973 2063512
SGTC_123 0083-0120 66.675 µM 0.860481141462068 0.203828437133594 no 674 0.194761937322807 940 16001701
SGTC_2032 5185112 25.99 µM 0.860472191140686 0.203830949604613 no 675 0.194764403183373 915 5718189
SGTC_1262 0737-0114 49.6 µM 0.860017272748527 0.203958675394726 no 676 0.194889760602495 1027 765919
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.859104529317713 0.20421508685477 no 677 0.195141424337068 1021 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1119 parthenolide 318.541 nM 0.85878107530581 0.204305998871043 no 678 0.195230655205887 1008 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2148 5546263 113.568 µM 0.857320900721208 0.204716704539981 no 679 0.195633780323941 962 792097
SGTC_1382 3002-2117 298 µM 0.856117702358916 0.205055498870956 no 680 0.195966338916236 1036 1497314
SGTC_995 3931-2021 34.6 µM 0.855866910989433 0.205126158180756 no 681 0.196035699687198 917 730143
SGTC_1773 st048542 73.5835 µM 0.853947369186976 0.205667459254713 no 682 0.196567075814616 919 3237138
SGTC_214 4373-3496 70 µM 0.853536256886339 0.205783500981432 no 683 0.196680995118601 1103 3779166
SGTC_2149 5554786 194.827 µM 0.852520693907146 0.206070323147664 no 684 0.196962579191164 999 745063 YPR165W RHO1
SGTC_3036 9090181 49.47 µM 0.850541222951161 0.206630059598829 no 685 0.197512125931165 953 25236586
SGTC_2189 6047310 154.431 µM 0.846927844413906 0.207654136181967 no 686 0.198517670624293 940 711535
SGTC_1322 1348-1070 12 µM 0.846867679194228 0.20767121309784 no 687 0.19853443972579 980 6758089
SGTC_2533 agelasine 13.65 µM 0.846655897357855 0.207731330516437 no 688 0.19859347383354 1000 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2867 9039098 71.43 µM 0.846542808781897 0.207763436597736 no 689 0.198625001567575 928 6463460
SGTC_2924 9010168 62.78 µM 0.844235968346455 0.208418992843818 no 690 0.199268779528044 980 2993929
SGTC_3140 9094243 49.47 µM 0.843719316698942 0.208565981568398 no 691 0.199413135342354 1070 19291112
SGTC_2903 5923464 63.88 µM 0.842125195688911 0.209019898150047 no 692 0.1998589397213 1000 2876576
SGTC_1958 st076513 41.9 µM 0.841871146840922 0.209092290776849 no 693 0.199930041159842 997 732122 YGL099W LSG1
SGTC_2553 4-methylesculetin 85.09 µM 0.839468990639863 0.209777527972654 no 694 0.2006030916465 1024 5319502
SGTC_450 aminopyrene 156 nM 0.838981131394828 0.209916855438864 no 695 0.200739948983061 972 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3234 9132280 49.47 µM 0.838022949468549 0.210190660363945 no 696 0.201008907264946 976 17612295
SGTC_199 4063-0024 41.6 µM 0.83545728139132 0.210924843915737 no 697 0.201730144815551 1017 306215
SGTC_1046 2001-0062 216 µM 0.835356528831993 0.210953705602463 no 698 0.201758499059614 940 739778
SGTC_78 0336-0123 156.75 µM 0.834487235466968 0.211202820472017 no 699 0.202003238672328 900 6765896
SGTC_1458 k015-0034 6.33 µM 0.834375997872428 0.211234710452961 no 700 0.202034569164379 950 3598957
SGTC_3185 9108267 49.47 µM 0.832416601791154 0.211796899308174 no 701 0.202586917176626 1007 4910486
SGTC_1677 st019204 53.9 µM 0.832311109476092 0.211827191921937 no 702 0.202616680735238 917 3945625
SGTC_375 3970-0961 9.27 µM 0.832272447943999 0.211838294397199 no 703 0.202627589338492 986 2898222
SGTC_3212 9128307 49.47 µM 0.829799939025922 0.212549034390069 no 704 0.203325952656988 855 27243542
SGTC_2496 diffractaic acid 79.83 µM 0.826518176944622 0.213494547862211 no 705 0.204255105630713 1003 94870 An apoptosis inducer which activates caspases.
SGTC_767 0929-0023 86 µM 0.8264311748271 0.213519647483032 no 706 0.204279772566862 1065 1204563
SGTC_2266 7929956 200 µM 0.825883013540376 0.213677828470817 no 707 0.204435228647667 1029 2967153
SGTC_2951 9072950 58.06 µM 0.824969737696495 0.213941520845672 no 708 0.204694385910286 1087 16488155
SGTC_273 hydroxyurea 18.1 mM 0.824475634890733 0.214084263298585 no 709 0.204834677257713 1061 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2388 9080168 200 µM 0.820643096991806 0.215193334437906 no 710 0.205924795897506 937 15943073
SGTC_1957 st077035 62.4 µM 0.820459089149244 0.215246666940065 no 711 0.205977221118776 1048 705593
SGTC_1771 st048882 4.1505 µM 0.820055263497228 0.215363737927629 no 712 0.20609230183672 1031 4580403
SGTC_1186 1319-0216 26 µM 0.819700963217539 0.215466481691548 no 713 0.206193300391334 1064 4565136
SGTC_3122 9126309 49.47 µM 0.818247670152328 0.215888220464555 no 714 0.206607890072893 1086 17591206
SGTC_2695 st077686 51.995 µM 0.815646755053851 0.216644186608289 no 715 0.207351100057478 1007 2876092
SGTC_2451 5856223 45.7 µM 0.814505083764592 0.216976500796727 no 716 0.207677830528171 988 2179896
SGTC_1866 st057638 64 µM 0.814430594307861 0.216998193193404 no 717 0.207699158941252 1003 688802
SGTC_528 3492-0019 172 µM 0.814101668829417 0.217093995989283 no 718 0.207793354969205 1104 2869262
SGTC_420 mitomycin C 81.9 mM 0.813480573893923 0.217274962652048 no 719 0.207971289808555 998 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3222 9128301 49.47 µM 0.812771313938478 0.217481724218865 no 720 0.208174592644385 1036 4911358
SGTC_813 k007-0158 173 µM 0.811960827840868 0.217718133953424 no 721 0.208407054541703 1082 6523916
SGTC_2988 9073640 71.4286 µM 0.810609688744026 0.218112575544914 no 722 0.208794925555904 978 9102229
SGTC_3170 9103054 49.47 µM 0.809511846781281 0.218433374519481 no 723 0.209110395655366 985 16432970
SGTC_1443 4112-3303 14 µM 0.804635334383931 0.219861614068746 no 724 0.210515072851485 1062 704433
SGTC_2152 5568786 200 µM 0.804424020801759 0.219923624797682 no 725 0.210576066556765 1023 5399883
SGTC_567 1080-0542 68.4 µM 0.803086644526186 0.220316315356494 no 726 0.21096232824682 986 5950415
SGTC_2749 bexarotene 57.39 µM 0.802565028134076 0.22046958521732 no 727 0.211113094287795 997 82146 An retinoic acid receptor inhibitor.
SGTC_446 go6976 132 µM 0.802056396053141 0.220619098642147 no 728 0.21126016818338 1037 3501 A protein kinase C inhibitor.
SGTC_1786 berberine 21.6 µM 0.800474161762593 0.221084570816153 no 729 0.211718063980451 986 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2414 st077232 92.9 µM 0.798728529554396 0.221598763886442 no 730 0.212223920125731 966 729801
SGTC_1822 st052468 42 µM 0.797964899823499 0.221823913216 no 731 0.212445429685066 1046 2873678
SGTC_2747 doxorubicin 7.63 µM 0.796979424182374 0.222114664834894 no 732 0.212731490645503 899 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3031 9088762 49.47 µM 0.79656454063559 0.22223713580122 no 733 0.212851989053223 1075 205253
SGTC_1564 D-Arginine 115 µM 0.7944636998121 0.222857881808033 no 734 0.213462766700739 1036 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1359 1582-0056 520 nM 0.79417393692722 0.222943576959418 no 735 0.213547089579328 1083 3661189
SGTC_2926 9010726 65.15 µM 0.792449314959084 0.223454008838434 no 736 0.214049367156513 1042 2994293
SGTC_2064 5220758 200 µM 0.789176104747289 0.224424598370891 no 737 0.215004542975319 1089 788518
SGTC_2502 avocadyne acetate 18.59 µM 0.788449689824702 0.224640322712676 no 738 0.215216857744823 1105 3952079
SGTC_1429 4049-0205 9.46 µM 0.787773252490167 0.224841310867105 no 739 0.215414674559792 1095 22774478
SGTC_1707 st032323 6.317 µM 0.786124062249536 0.225331757737627 no 740 0.215897404328574 1022 3132057 YMR211W DML1
SGTC_286 k060-0067 22.9 µM 0.785948560756295 0.22538398514738 no 741 0.21594881174632 1026 5985051
SGTC_789 1309-1135 70.6 µM 0.784424517027534 0.225837812711668 no 742 0.216395528578357 1100 3092424
SGTC_1355 1499-0035 1.68 µM 0.784171020839909 0.225913348541832 no 743 0.216469883417335 1041 1548538
SGTC_1192 1488-0095 21.4 µM 0.780881104693585 0.226894960074973 no 744 0.217436213163895 1019 915875
SGTC_3102 9121669 49.47 µM 0.776850606658427 0.228100811251922 no 745 0.218623457740273 1075 41905072
SGTC_2623 humulene 100 µM 0.774027756190647 0.228947497817911 no 746 0.219457188758284 982 6187145 An anti-inflammatory.
SGTC_916 4466-0038 42 nM 0.773190748866584 0.229198888596981 no 747 0.219704750159782 1145 5722064 YGL116W CDC20
SGTC_2968 9090663 33.37 µM 0.772922365610541 0.22927952886924 no 748 0.219784163730069 1028 25236811
SGTC_1737 st035557 69.7 µM 0.770775161501063 0.229925264958766 no 749 0.22042010612987 949 5716916
SGTC_1444 4112-3581 28 µM 0.770751825299002 0.229932288522608 no 750 0.220427023455164 1084 2877249
SGTC_1843 st055809 45.5 µM 0.769757469596826 0.230231674173298 no 751 0.22072188630458 1033 16413835
SGTC_3325 9138760 55.175 µM 0.768821254179115 0.23051375382175 no 752 0.220999714796524 1062 43844959
SGTC_619 1652-1634 108 µM 0.768727899593993 0.230541891940132 no 753 0.221027429394523 1013 5400454
SGTC_1732 st034308 51.822 µM 0.768063518128364 0.230742199393702 no 754 0.221224724766803 1010 830119
SGTC_721 1187-1332 279 µM 0.767147926854713 0.23101840449171 no 755 0.221496784659865 977 25730
SGTC_748 act1.228 77.9 µM 0.76410436266571 0.231937877217473 no 756 0.222402526343997 1080 4421505 YNR035C ARC35
SGTC_2192 5915882 198.485 µM 0.759576977035799 0.2333093809149 no 757 0.223753742650459 1053 2876149
SGTC_249 wiskostatin 11.211 µM 0.759455077874379 0.233346370553814 no 758 0.223790188344777 1116 2775510 A n-wasp and actin depolymerizer.
SGTC_122 0236-0016 402.397 µM 0.759038393306745 0.233472835793305 no 759 0.223914795142846 1186 6808838
SGTC_1467 k284-1082 293 µM 0.757783708817456 0.233853866463925 no 760 0.224290238342832 1103 3334705
SGTC_2673 kobusone 100 µM 0.757609379481087 0.233906835171978 no 761 0.224342431723919 1150 6710676 An epoxy ketone and protein crosslinker.
SGTC_2600 tangeritin 87.95 µM 0.757355111969529 0.233984104433558 no 762 0.224418570577739 1089 68077 A bioactive flavone.
SGTC_1637 st007924 17.4 µM 0.757219860149001 0.234025211820472 no 763 0.224459076884169 1093 683336
SGTC_790 1575-0012 79.1 µM 0.757151125315456 0.234046104084355 no 764 0.224479663736604 1142 378741 YLR208W SEC13
SGTC_730 1436-0052 41.2 µM 0.756569601294161 0.234222902278604 no 765 0.224653879567206 1137 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1626 st003712 1.76 µM 0.756087270315089 0.234369599324765 no 766 0.224798436823761 1039 24207035
SGTC_2236 dapsone 200 µM 0.75606844310896 0.23437532649735 no 767 0.224804080510688 1142 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2416 tofa 880 nM 0.755887291101216 0.234430436284413 no 768 0.22485838716133 1013 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1074 carmofur 3.8 µM 0.755563326476562 0.234529010181985 no 769 0.224955525430651 1163 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3106 9121286 49.47 µM 0.755493263677446 0.234550331460427 no 770 0.224976536342916 1110 15943471
SGTC_1386 3228-0095 33.8 µM 0.753834034193361 0.235055575902212 no 771 0.225474442397234 1083 870181
SGTC_1054 3429-0080 167 µM 0.752661992799577 0.235412830937307 no 772 0.225826527334506 1132 1162877
SGTC_1078 idebenone 36.1 µM 0.752186341216072 0.235557901806786 no 773 0.225969503224977 1119 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1629 st005085 44.9 µM 0.751827407332861 0.235667407123845 no 774 0.226077428867752 1104 24207091
SGTC_2085 5307070 144.047 µM 0.751591472441955 0.235739402593013 no 775 0.226148386559301 1077 2840351
SGTC_615 k087-0205 167 µM 0.749492032656743 0.236380579923588 no 776 0.226780349493883 1106 9642773
SGTC_1860 st056228 74.6 µM 0.749203722767918 0.236468705830953 no 777 0.226867212848635 1117 688679
SGTC_1897 st060201 15 µM 0.747640007661003 0.236946991854357 no 778 0.227338663071967 1084 611878
SGTC_2117 5521686 200 µM 0.74720624936985 0.237079757568051 no 779 0.227469536183945 1112 803312
SGTC_1768 st044301 37.178 µM 0.746542083661476 0.237283126094371 no 780 0.227670009796025 1159 3931349
SGTC_2471 5466956 24.79 µM 0.746100718359124 0.237418325777994 no 781 0.227803287710281 1091 724419
SGTC_2068 5226020 147 µM 0.745557989025128 0.237584633405875 no 782 0.227967234427577 1179 1810509
SGTC_1698 5-fluorocytosine 1.055 µM 0.744792296834129 0.237819371843248 no 783 0.228198646204726 1136 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1024 4507-0395 26 µM 0.743713064372211 0.238150448272751 no 784 0.228525042020246 1109 4201836
SGTC_261 5-fluorouridine 15.376 µM 0.741896526609917 0.238708277891327 no 785 0.229075015227524 1118 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2170 morpholine 200 µM 0.741050106730858 0.238968443828064 no 786 0.229331529847544 1117 121171 Reacts with secondary amines.
SGTC_1151 3909-8316 15.3 µM 0.739720028358506 0.239377585986373 no 787 0.229734946359007 1121 800431
SGTC_3074 9116018 49.47 µM 0.739643121577517 0.239401254788453 no 788 0.229758284549657 1172 17027303
SGTC_1286 0929-0070 131 µM 0.739522555271948 0.239438362801793 no 789 0.229794874365073 1151 1420408
SGTC_1545 lovastatin 49.4 µM 0.737398457009319 0.240092634662086 no 790 0.230440036763786 1176 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3169 9102970 49.47 µM 0.73666934805095 0.240317441728464 no 791 0.230661725687253 1174 17027839
SGTC_2025 5147754 141 µM 0.736470898647445 0.240378649727333 no 792 0.230722085761634 1140 315777 YLR208W SEC13
SGTC_700 3453-2283 142 µM 0.735890228762398 0.240557795236595 no 793 0.230898752117824 1164 565664
SGTC_495 decylubiquinone 155 µM 0.735007741710894 0.240830195071904 no 794 0.231167389638237 1109 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2883 9059145 45.46 µM 0.734381344779029 0.24102364861984 no 795 0.231358176647287 1146 16476510
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.733588316985215 0.241268684840261 no 796 0.231599841741314 1248 5282309
SGTC_2981 9013952 38.96 µM 0.731711341817584 0.24184918700794 no 797 0.232172386159756 1092 2996344
SGTC_820 1582-0060 59.9 µM 0.727957620971316 0.243012390145072 no 798 0.233319764437201 1120 3848840
SGTC_940 3232-1287 54.8 µM 0.727682344329596 0.243097811813445 no 799 0.233404030319352 1129 1585493 YIL048W NEO1
SGTC_3310 9130229 44.1445 µM 0.72720745379875 0.243245214244245 no 800 0.233549440377423 1124 7761258
SGTC_1618 st003135 44.5 µM 0.726259493902647 0.243539598251061 no 801 0.23383985303706 1116 1270615
SGTC_3056 9094900 49.47 µM 0.725996185690665 0.243621401379994 no 802 0.233920554435199 1107 25236784
SGTC_595 3909-8003 73.7 µM 0.725548245621301 0.243760598991391 no 803 0.234057879143909 1161 699517
SGTC_664 1222-0054 14.9 µM 0.725358153731551 0.243819683118619 no 804 0.234116168988105 1174 6813991
SGTC_3179 9107801 49.47 µM 0.720913411035291 0.245203393284003 no 805 0.235481395524221 1172 4818259
SGTC_2121 5257820 149.641 µM 0.720490385477997 0.245335306719075 no 806 0.235611558645961 1198 791256
SGTC_2161 5662504 8.5105 µM 0.719456752837279 0.245657788150936 no 807 0.235929769805902 1114 2859334
SGTC_1825 st052143 62.6 µM 0.717249412709189 0.246347214186302 no 808 0.236610107511299 1148 674173
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.715986398777206 0.246742161604364 no 809 0.23699987367389 1174 2724 A muscle relaxant with antifungal properties.
SGTC_1068 loratadine 26.9 µM 0.715896864601801 0.246770172013917 no 810 0.237027517313163 1147 3957 A H1 histamine antagonist.
SGTC_3035 9091303 49.47 µM 0.715872164759992 0.246777899560476 no 811 0.237035143690852 1184 25237002
SGTC_2558 carylophyllene oxide 100 µM 0.715472915840988 0.246902825804472 no 812 0.237158435373369 1250 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2842 9000675 19.48 µM 0.714544789338663 0.247193370259002 no 813 0.237445185345915 1142 2989072
SGTC_3071 9117417 49.47 µM 0.713769505379614 0.247436208351184 no 814 0.237684859569613 1095 45595590 YGL055W OLE1
SGTC_2316 5844804 197.44 µM 0.71347750300485 0.247527703750473 no 815 0.237775164688572 1238 776813
SGTC_1292 0kpi-0043 232 µM 0.713207367877436 0.247612363406865 no 816 0.237858723862938 1144 3333905
SGTC_2971 9092186 9.93 µM 0.713083839501795 0.247651082035916 no 817 0.237896939471467 1134 25236400
SGTC_2315 7733312 200 µM 0.711647953828613 0.248101381973091 no 818 0.238341402097623 1156 726316
SGTC_1955 wogonin 32.4 µM 0.710108452730017 0.248584660905961 no 819 0.238818442500319 1181 5281703 A flavanone.
SGTC_3210 9128157 49.47 µM 0.710002491454272 0.248617942620093 no 820 0.238851295589649 1122 17590849
SGTC_607 4491-0986 66.8 µM 0.709557962185571 0.248757592093808 no 821 0.23898914796609 1198 698981 YDR232W HEM1
SGTC_1567 st069303 68.4 µM 0.709209561606682 0.248867071798025 no 822 0.239097220402522 1209 5581319
SGTC_3067 9117431 49.47 µM 0.709012545116231 0.248928992652955 no 823 0.23915834593482 1171 17150885
SGTC_687 k029-0044 34.9 µM 0.70779756903015 0.249311031960756 no 824 0.239535488113094 1197 5829338
SGTC_2015 5119600 184 µM 0.707582252505995 0.249378768985076 no 825 0.239602358626372 1170 2828786
SGTC_577 r071-0003 38.6 µM 0.707540667404121 0.249391852485001 no 826 0.239615274819845 1222 4568517 YMR134W ERG29
SGTC_2586 curcumin 80 µM 0.7070222473818 0.249554988353286 no 827 0.2397763262408 1192 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3038 9091290 49.47 µM 0.706768636421664 0.249634815030841 no 828 0.239855134068041 1185 25236843
SGTC_53 0973-0023 39.979 µM 0.70631811976985 0.249776653255691 no 829 0.239995163794136 1157 674768
SGTC_2448 5185112 27.17 µM 0.70556229558604 0.250014708931916 no 830 0.24023018939651 1169 5718189
SGTC_837 0091-0265 12.5 µM 0.70512202806854 0.250153431808174 no 831 0.240367149575132 1145 759367
SGTC_2308 7584454 197.62 µM 0.703576500186546 0.250640731653779 no 832 0.240848275135292 1222 893577
SGTC_2000 st075254 36.4 µM 0.701570619905709 0.251273928077625 no 833 0.241473489681312 1149 17234175
SGTC_458 nppb 133 µM 0.700440351317285 0.251631092290326 no 834 0.241826171986581 1203 4549 A chloride channel blocker.
SGTC_145 3737-0113 38.366 µM 0.69973127203649 0.251855297739925 no 835 0.242047571478435 1247 6849351
SGTC_1393 3470-5649 58.2 µM 0.699591509142088 0.251899502136985 no 836 0.242091223334855 1112 4108395
SGTC_194 1486-1323 56.904 µM 0.698655297456123 0.252195713992623 no 837 0.242383738435867 1178 5178754
SGTC_1863 st057641 20.1 µM 0.698459675702174 0.252257630755314 no 838 0.242444883745276 1215 3921635
SGTC_2175 5807670 165.306 µM 0.6976128729454 0.252525746970988 no 839 0.242709664442603 1152 241186
SGTC_2350 9023895 38.85 µM 0.69708698831126 0.252692329057084 no 840 0.242874178308851 1193 2997209
SGTC_795 0685-0265 78 µM 0.69586144512382 0.253080763271541 no 841 0.243257802233694 1254 302754
SGTC_2184 6075246 200 µM 0.695322787504906 0.253251589372949 no 842 0.243426518333261 1201 2267320
SGTC_688 0527-0193 473 µM 0.694510165819085 0.253509413196159 no 843 0.243681163906113 1191 4007154
SGTC_2280 7785178 200 µM 0.693331762292373 0.25388353498432 no 844 0.244050687333958 1193 2954328
SGTC_2948 9070189 9.45 µM 0.692719735478595 0.254077956694136 no 845 0.244242725706547 1114 6473636 YDL196W YDL196W
SGTC_2874 9043904 71.43 µM 0.69043332517993 0.254804967798236 no 846 0.24496086289135 1131 4463428
SGTC_3043 9092303 49.47 µM 0.690428066801107 0.254806641061987 no 847 0.244962515800678 1165 25236084
SGTC_2363 9053361 176 µM 0.689595256273078 0.255071721491896 no 848 0.24522437568396 1230 6469797 YMR079W SEC14
SGTC_374 0880-0231 82.3 µM 0.689496324357947 0.255103220728051 no 849 0.245255492757461 1182 6833587
SGTC_2394 5221648 200 µM 0.689022021887093 0.255254263602228 no 850 0.245404704680895 1255 788586
SGTC_2977 9011197 71.43 µM 0.688793408575983 0.255327082810513 no 851 0.245476642097275 1188 2704722
SGTC_1324 1418-0026 34.4 µM 0.688240637860084 0.255503199333179 no 852 0.245650628458327 1213 1372513
SGTC_1339 1486-1321 22.7 µM 0.686959442201318 0.255911640905463 no 853 0.246054143414259 1222 3469382
SGTC_2598 perillyl alcohol 100 µM 0.686049119193675 0.25620205623339 no 854 0.246341067271511 1207 10819 An apoptosis inducer.
SGTC_985 1493-0307 8.71 µM 0.685962142274087 0.256229812991007 no 855 0.246368490828695 1195 3278274
SGTC_3264 9137442 49.47 µM 0.685654007924241 0.256328159858763 no 856 0.246465657813905 1231 17015726
SGTC_661 1304-0007 33.6 µM 0.685204453411383 0.256471678912152 no 857 0.246607457013318 1215 3117130
SGTC_1966 st070145 16.1 µM 0.684797909421341 0.256601503012973 no 858 0.246735727382259 1170 3748532
SGTC_2950 9072895 21.46 µM 0.682387519901552 0.257371929407043 no 859 0.24749697255514 1180 17332245
SGTC_2841 9004761 38.96 µM 0.68196247752775 0.257507909131606 no 860 0.247631338762797 1136 2991039
SGTC_684 1140-0066 328 µM 0.681892179913465 0.25753040236809 no 861 0.247653565298742 1228 6813534
SGTC_989 1501-0895 10.3 µM 0.681679981539019 0.257598305999583 no 862 0.247720664148494 1214 2830112
SGTC_131 0141-0277 33.849 µM 0.680500214998412 0.257976001612457 no 863 0.248093892869837 1172 1547771
SGTC_1212 0520-0165 585 µM 0.680313982610043 0.258035649104207 no 864 0.248152836398819 1342 5403258
SGTC_897 1000-0139 31.4 µM 0.680243127607387 0.258058344796474 no 865 0.248175264340616 1201 6151020
SGTC_2470 5664817 21.68 µM 0.678970851736197 0.258466045868303 no 866 0.248578165472102 1252 2859561
SGTC_573 3702-0553 84.7 µM 0.678345886794722 0.258666438148369 no 867 0.248776205351487 1207 1222756
SGTC_2274 7947094 46.08 µM 0.677553990227382 0.258920471804565 no 868 0.249027263399558 1228 2971028
SGTC_961 1252-1571 372 µM 0.676519582268431 0.259252495336827 no 869 0.249355408719666 1227 6813498
SGTC_3290 9121031 71.43 µM 0.676411674661664 0.259287144113915 no 870 0.2493896534934 1200 17014854
SGTC_330 1488-0319 80.1 µM 0.67487282156677 0.259781525041942 no 871 0.249878284620654 1225 6846614
SGTC_3243 9134147 49.47 µM 0.674489860083278 0.259904633026903 no 872 0.249999965080425 1280 24282180
SGTC_2346 9031566 143.75 µM 0.673697352636288 0.260159490467162 no 873 0.250251872656842 1196 4771086
SGTC_2895 9054447 58.44 µM 0.6734770641216 0.260230354524683 no 874 0.250321917784813 1258 2697450
SGTC_717 1532-0246 73.2 µM 0.673091897313096 0.260354281762168 no 875 0.25044441422584 1215 9561992
SGTC_3058 9093861 49.47 µM 0.67135298748936 0.260914153395056 no 876 0.250997843270207 1251 17217477
SGTC_1206 3978-0017 132 µM 0.670355202166251 0.261235686726375 no 877 0.251315692446466 1288 3873677
SGTC_3163 9099914 49.47 µM 0.670254710272924 0.261268081219237 no 878 0.251347716399664 1250 16268368
SGTC_1170 0310-0127 64.8 µM 0.669882780158297 0.261387994289548 no 879 0.251466258879348 1223 774975
SGTC_757 1066-0008 322 µM 0.669838525107767 0.261402264332653 no 880 0.25148036592439 1247 6842497
SGTC_2945 9067681 61.76 µM 0.669188603317055 0.261611877716801 no 881 0.251687587634707 1313 16456930
SGTC_6 0844-0013 19.835 µM 0.668751878876566 0.261752778937757 no 882 0.251826883931483 1336 1584900
SGTC_1215 3852-0577 11.2 µM 0.668021012778987 0.261988666695709 no 883 0.252060089772154 1289 2884876
SGTC_893 0958-0369 48.9 µM 0.667513149750162 0.262152644144954 no 884 0.252222206530531 1244 6819948
SGTC_2925 9010536 32.5 µM 0.667045319549591 0.26230374242514 no 885 0.252371592907566 1245 2994177
SGTC_614 0462-0418 107 µM 0.66663456996388 0.262436441758802 no 886 0.252502790884309 1141 5188303
SGTC_2090 5301565 104.445 µM 0.665096270971837 0.262933719488699 no 887 0.252994459806276 1268 2056344
SGTC_739 1486-1183 203 µM 0.66404121685381 0.26327505950164 no 888 0.253331965700493 1236 4346692
SGTC_3123 9126162 49.47 µM 0.662749339818785 0.263693326458869 no 889 0.253745552036488 1302 25239884
SGTC_1478 0453-0656 35.7 µM 0.660804699820673 0.264323574915968 no 890 0.254368784206698 1259 5258496
SGTC_1638 st008370 60.6 µM 0.66079513832086 0.264326675645612 no 891 0.254371850525636 1248 24207134
SGTC_2256 7954252 200 µM 0.660221374799011 0.264512777162072 no 892 0.254555888700682 1203 2972920
SGTC_2293 7624732 200 µM 0.659506899510435 0.264744612028335 no 893 0.254785158512189 1225 894453
SGTC_581 0958-0271 211 µM 0.659431729128494 0.264769009522013 no 894 0.254809286412848 1261 4591145
SGTC_3044 9093193 49.47 µM 0.658628047976733 0.265029925783007 no 895 0.255067323640485 1218 25236277
SGTC_1853 st056710 91.2 µM 0.657910899432229 0.265262859344296 no 896 0.255297693268857 1340 269167
SGTC_833 3852-0053 558 µM 0.65630067291007 0.265786247665359 no 897 0.25581534233976 1307 3123681
SGTC_1571 st070080 73.4 µM 0.655875210988544 0.265924627262184 no 898 0.255952209554671 1299 4315245
SGTC_3046 9092212 49.47 µM 0.65576138104204 0.265961656134542 no 899 0.255988834086527 1269 25236637
SGTC_3323 9138564 53.9225 µM 0.655658042181326 0.265995274519555 no 900 0.256022085502497 1261 43912313 YNL103W MET4
SGTC_2865 9030313 51.95 µM 0.655025187208709 0.26620120299082 no 901 0.256225768820715 1208 42562754
SGTC_1235 benzylparaben 21.5 µM 0.654244541999514 0.266455332947774 no 902 0.256477134512531 1249 7180
SGTC_949 1165-0505 146 µM 0.653791572143804 0.266602848254911 no 903 0.256623048486987 1270 6244267
SGTC_2776 terbinafine 19.92 µM 0.653268395419153 0.266773278683762 no 904 0.256791631797673 1263 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1042 0350-0096 82 µM 0.653030236941323 0.266850879595251 no 905 0.256868392726858 1267 3122515
SGTC_2119 5528445 120.635 µM 0.652633919650296 0.266980039821247 no 906 0.256996156333358 1284 791935
SGTC_1010 4112-3296 15.2 µM 0.652078468171042 0.267161115169268 no 907 0.257175276771207 1296 704384
SGTC_346 4513-0042 7.16 µM 0.650976899186387 0.267520406310361 no 908 0.257530699571871 1271 2827372
SGTC_2753 fluvastatin 17.09 µM 0.650559091001626 0.267656743618886 no 909 0.257665572681797 1277 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_505 gw-5074 63.9 µM 0.64771842432071 0.268584624841159 no 910 0.258583542726741 1309 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_167 3672-0051 66.205 µM 0.647516401295182 0.268650675582828 no 911 0.258648891520896 1228 3237971
SGTC_1466 k213-0079 57.5 µM 0.646349681385763 0.269032290305728 no 912 0.259026459960129 1246 3657981
SGTC_2768 sulfasalazine 50.2 µM 0.645934601829256 0.269168121526409 no 913 0.259160854773092 1336 5384001 An antioxidant and salicylic acid derivative.
SGTC_2398 5228213 48.84 µM 0.645213520205292 0.269404171069873 no 914 0.259394412871191 1285 80771 YMR134W ERG29
SGTC_2798 7813637 45.45 µM 0.645085841435029 0.269445978142521 no 915 0.259435779310746 1268 956368
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.644481034026093 0.269644060156441 no 916 0.259631776181218 1322 165506
SGTC_1495 4469-0029 237 µM 0.643714239249286 0.269895299895164 no 917 0.259880377322318 1280 793680
SGTC_1920 st075728 45.7 µM 0.643200744589503 0.270063611524419 no 918 0.260046925116117 1327 3400306
SGTC_1730 st033808 45.1 µM 0.641137500742476 0.270740423934333 no 919 0.260716675765361 1289 1045166
SGTC_1431 4049-0260 9.09 µM 0.639448245988495 0.271295185315808 no 920 0.261265685762728 1273 3854841
SGTC_1726 st035556 14.5795 µM 0.638864629607584 0.27148698002908 no 921 0.261455499804884 1362 5919439
SGTC_1396 3511-0007 98.6 µM 0.638670491239236 0.27155079497476 no 922 0.261518656610464 1241 X1396
SGTC_672 1441-0018 53.7 µM 0.638123260437855 0.271730714626009 no 923 0.261696723066238 1256 251141
SGTC_3082 9117008 49.47 µM 0.637691874078739 0.271872588517526 no 924 0.261837138097121 1289 41448529
SGTC_2717 st081029 62.2815 µM 0.637338447875095 0.271988850413501 no 925 0.261952206110919 1264 5292846
SGTC_918 glabranin 770.725 nM 0.636915579013268 0.272127988416263 no 926 0.262089917231009 1317 124049 Also referred to as licorice root.
SGTC_2006 4011487 200 µM 0.635945845311272 0.272447196797939 no 927 0.262405859946662 1337 45595294
SGTC_418 lividomycin a 100 µM 0.635918991149183 0.272456039059357 no 928 0.262414611903098 1286 72394 An antibiotic.
SGTC_1414 3917-0015 5.4 µM 0.635227030330041 0.272683929914391 no 929 0.26264017823336 1267 6618702
SGTC_1914 st062367 72.6 µM 0.634613682239926 0.272886009452329 no 930 0.262840201191296 1297 978205
SGTC_1301 naphtanilide LB 4.81 µM 0.632908499756176 0.273448205179117 no 931 0.263396698451063 1338 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1103 duloxetine 36.1 µM 0.632485187292707 0.273587859359229 no 932 0.263534942335667 1371 60835 A selective serotonin reuptake inhibitor.
SGTC_1027 k015-0025 8.67 µM 0.630589895107152 0.274213563904504 no 933 0.264154353837763 1274 3598955
SGTC_16 erodoxin 22.806 µM 0.630074647810267 0.27438378778589 no 934 0.264322872929499 1316 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2727 riluzole 51.77 µM 0.630020321637439 0.274401738734947 no 935 0.26434064428048 1291 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3305 9127027 53.8275 µM 0.629639233065691 0.27452767778615 no 936 0.264465324287202 1251 41905295
SGTC_799 1310-0557 151 µM 0.6290164459445 0.274733552773148 no 937 0.264669144735954 1316 5354492
SGTC_873 0591-4978 488 µM 0.628254342741165 0.274985585061702 no 938 0.26491866801325 1422 3305145
SGTC_1952 st077036 64.1 µM 0.625669068768051 0.275841398986035 no 939 0.26576601271068 1305 2937007
SGTC_2639 lactacystin 53 µM 0.625642822609724 0.27585009406614 no 940 0.265774622143266 1328 3870 A proteasome inhibitor.
SGTC_981 1488-1094 54.9 µM 0.625512096760448 0.275893404190142 no 941 0.265817505777383 1273 3449522
SGTC_2663 amphotericin b 100 µM 0.625118116105846 0.276023952141533 no 942 0.265946769383781 1280 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_579 4491-1009 110 µM 0.62410007882492 0.276361425548785 no 943 0.266280931080024 1412 1271041
SGTC_2990 9074105 71.4286 µM 0.623443204959955 0.276579282767812 no 944 0.266496656833014 1278 6502001
SGTC_1146 3579-1023 7 µM 0.623207934207297 0.276657332574703 no 945 0.266573944243172 1388 X1146
SGTC_2114 5491910 81.25 µM 0.623183648340046 0.276665389895111 no 946 0.266581922895821 1362 2849228
SGTC_1757 st041620 31.8375 µM 0.622698383997349 0.276826410111228 no 947 0.266741372432057 1290 5289815
SGTC_1376 2910-0861 41.3 µM 0.622514373472143 0.27688748040908 no 948 0.266801847735412 1352 1112859
SGTC_487 nimodipine 119 µM 0.621787391860018 0.277128819063465 no 949 0.267040838946436 1216 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2998 9066762 71.4286 µM 0.621485508247803 0.277229066669852 no 950 0.267140113281544 1363 4945196
SGTC_2567 aureobasidin a 60 nM 0.620822957647962 0.277449144463058 no 951 0.267358058141992 1380 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1337 1486-1011 40.3 µM 0.619807053543881 0.277786760591782 no 952 0.267692412146423 1307 X1337
SGTC_2696 st077691 74.316 µM 0.619591608425757 0.277858385393891 no 953 0.267763346442415 1327 757133
SGTC_3142 9086498 49.47 µM 0.618819663094822 0.278115092876783 no 954 0.268017583562321 1252 25236367
SGTC_1504 k297-0033 30 µM 0.615518414097531 0.279214214050009 no 955 0.269106206192851 1218 4388117
SGTC_2723 salbutamol 83.58 µM 0.614072734967277 0.279696203748169 no 956 0.269583632152641 1318 9884233 β2-adrenoceptor agonist
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.613158711841747 0.28000114742898 no 957 0.269885701068539 1300 6857784
SGTC_2362 9071156 126 µM 0.612234891182779 0.280309523530866 no 958 0.270191179971883 1373 653133
SGTC_2575 plumbagin 510 nM 0.611047768592723 0.280706032502177 no 959 0.270583978385698 1285 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1559 coumarin 343 70.1 µM 0.610091807151609 0.281025528763141 no 960 0.27090049675813 1371 108770 A hepatotoxic, DNA x-linker.
SGTC_647 0140-0236 81 µM 0.609012704682666 0.28138639153342 no 961 0.271258008922329 1334 990837
SGTC_2653 dihydrofissinolide 100 µM 0.608638841943867 0.281511467151634 no 962 0.271381926391585 1341 6857746
SGTC_1043 0916-0009 19.3 µM 0.608485848340967 0.281562658827854 no 963 0.271432644525199 1366 3101130
SGTC_2429 5902844 64.44 µM 0.608343839364871 0.281610179064404 no 964 0.271479725426334 1356 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1743 st037606 46.3785 µM 0.607871614910459 0.281768226587403 no 965 0.271636313460209 1360 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_389 tpck 16.7 µM 0.606837410735272 0.282114510855062 no 966 0.271979409080137 1314 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_156 3474-0145 5.642 µM 0.606059148467971 0.2823752327127 no 967 0.272237738415563 1281 2265471
SGTC_60 0986-0278 202 µM 0.605175545830687 0.282671384564415 no 968 0.272531181211411 1153 3110598
SGTC_2097 5376186 200 µM 0.603268153592713 0.283311182302043 no 969 0.273165157539552 1310 742755
SGTC_218 alverine citrate 93.75 µM 0.602587991724129 0.283539497263483 no 970 0.273391405402274 1354 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_572 0960-0087 17.7 µM 0.601965152740574 0.28374864753323 no 971 0.273598666834452 1304 6796365
SGTC_3153 9100258 49.47 µM 0.601097209258403 0.284040227410547 no 972 0.273887621025118 1293 25236848
SGTC_627 1391-0720 175 µM 0.597704277379684 0.285181433753843 no 973 0.275018635440233 1315 997839
SGTC_1191 1487-1166 10.6 µM 0.596847364442751 0.285470000076691 no 974 0.275304645952671 1428 3955771
SGTC_3244 9134489 49.47 µM 0.59497377615525 0.286101416703234 no 975 0.275930500136048 1292 16584271
SGTC_12 0849-0099 9.267 µM 0.593814613715496 0.286492397149039 no 976 0.276318056847305 1337 6071388
SGTC_3120 9124077 49.47 µM 0.593677863678524 0.286538539054236 no 977 0.276363795735442 1377 18774327 YGL155W CDC43
SGTC_1963 st076565 50.3 µM 0.5929410679692 0.286787207737427 no 978 0.276610296243003 1367 4914280
SGTC_801 0866-0028 10.1 µM 0.591868231824005 0.287149472929505 no 979 0.276969414171021 1357 6849771
SGTC_2563 tomatine 8.54 µM 0.591312509776963 0.287337209044005 no 980 0.277155524586442 1386 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_356 1634-0012 32.5 µM 0.590205282518746 0.287711429739602 no 981 0.277526515511098 1365 735457
SGTC_1486 3970-0793 4.53 µM 0.589732443275562 0.28787131010069 no 982 0.277685020377459 1387 2844330
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.589648428126024 0.287899722395314 no 983 0.277713188507426 1470 16725076
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.589173274565624 0.288060435033638 no 984 0.277872521598227 1465 6728940
SGTC_1750 st081859 2.357 µM 0.588423416700296 0.288314147847294 no 985 0.278124061939979 1361 5291695
SGTC_532 1548-0774 215 µM 0.58829867649272 0.288356363651437 no 986 0.27816591690134 1470 5932993
SGTC_1108 betulinic acid 729.144 nM 0.587590513962944 0.288596082178071 no 987 0.278403589872681 1355 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.583744566829826 0.28989960180632 no 988 0.279696089099356 1323 61125 An anti-inflammatory.
SGTC_588 3970-1144 52.9 µM 0.582071678767367 0.290467459782293 no 989 0.280259200366092 1341 1888707
SGTC_1673 st016611 27.3 µM 0.58195722607448 0.290506329505086 no 990 0.280297746377533 1442 5226799
SGTC_1453 4237-0541 195 µM 0.580742240016305 0.29091910563647 no 991 0.280707094336991 1350 739892
SGTC_3267 9137951 49.47 µM 0.580199290814218 0.291103654324729 no 992 0.280890115916915 1393 16643986
SGTC_1602 st001878 87.6 µM 0.579954153136546 0.291186994648431 no 993 0.280972767746936 1396 595405 YLR310C CDC25
SGTC_430 0958-0115 16.4 µM 0.576981390985613 0.29219854066199 no 994 0.281976013280211 1378 6833180
SGTC_3156 9099931 49.47 µM 0.575868197009106 0.292577749053711 no 995 0.282352136679601 1429 18111053
SGTC_2771 fluoxetine 41.05 µM 0.575321558835961 0.292764044464749 no 996 0.282536921836325 1415 3386 A selective serotonin reuptake inhibitor.
SGTC_1144 3486-0183 12.5 µM 0.575156639300538 0.292820260194628 no 997 0.282592682526632 1365 6744069
SGTC_3349 9149703 23.001 µM 0.574969058620063 0.292884206465987 no 998 0.282656111571305 1348 4910494
SGTC_2036 5160441 105 µM 0.574912978662417 0.29290332538723 no 999 0.282675075930139 1415 134534 YIL048W NEO1
SGTC_2003 4023581 200 µM 0.574298134411156 0.293112977625324 no 1000 0.282883035704644 1400 16641307
SGTC_1717 st033143 58.0435 µM 0.574037504656346 0.293201869279051 no 1001 0.282971211099893 1453 674616
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.572897394091318 0.293590867785007 no 1002 0.283357084561579 1425 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3251 9135047 49.47 µM 0.570219627458149 0.29450544319533 no 1003 0.284264372697874 1453 17682963
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.567813948605506 0.295328208112171 no 1004 0.285080653700073 1399 2724278 An inhibitor of dopamine biosynthesis.
SGTC_93 0109-0045 59.227 µM 0.567275431574259 0.295512530815875 no 1005 0.28526353313209 1410 88733
SGTC_37 0566-0070 1.56 µM 0.565616410814372 0.296080709910443 no 1006 0.285827284716727 1431 1626686
SGTC_2513 baicalein 25.65 µM 0.559081822507297 0.298323527360415 no 1007 0.288052939891126 1338 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2269 7935389 174.42 µM 0.557308589903973 0.298933472125775 no 1008 0.288658303886224 1365 97605
SGTC_1092 toremifene 6.32 µM 0.556838277758655 0.299095341967166 no 1009 0.288818964261781 1391 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_539 4859-0462 2.54 µM 0.556513078098155 0.299207290933575 no 1010 0.288930078282998 1439 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1800 st050079 29.0735 µM 0.554924058274447 0.299754579270434 no 1011 0.289473302671252 1356 3645560
SGTC_442 cape 100 µM 0.554907810775068 0.299760177555823 no 1012 0.289478859539207 1470 5281787
SGTC_1513 0337-0559 19 µM 0.554852749975149 0.299779149816445 no 1013 0.289497691461641 1324 775073
SGTC_2426 5582046 32.21 µM 0.553932618788713 0.300096279198657 no 1014 0.289812480303879 1436 2251934
SGTC_114 0364-0001 490.298 µM 0.55353460562617 0.300233504102715 no 1015 0.289948695516677 1360 4003655
SGTC_892 0929-0076 29 µM 0.552744645291227 0.30050594649951 no 1016 0.29021913881584 1394 5751038
SGTC_1450 4112-4260 37.6 µM 0.552644938510637 0.300540341418898 no 1017 0.290253281877216 1418 1633175
SGTC_414 piperonyl butoxide 100 µM 0.552383226013405 0.300630630397288 no 1018 0.290342910267147 1374 5794 A potent inhibitor of cytochrome P450.
SGTC_1893 st059353 36.1 µM 0.551051747511712 0.301090170645349 no 1019 0.290799100811202 1369 3112488
SGTC_357 1325-0123 420 µM 0.550205183559916 0.301382514281334 no 1020 0.291089324318127 1416 1098503
SGTC_524 r073-0010 27.8 µM 0.549750473315699 0.301539591944316 no 1021 0.291245266302821 1358 2772106
SGTC_3094 9117742 49.47 µM 0.548287951565994 0.302045063248625 no 1022 0.29174709950972 1354 17149698
SGTC_2693 st077581 40.7 µM 0.548093142984738 0.302112420970969 no 1023 0.291813974326769 1423 25238761
SGTC_2838 9002687 71.43 µM 0.547942863923115 0.302164386612273 no 1024 0.291865567717443 1399 6457060
SGTC_2125 5246583 200 µM 0.546783016795952 0.302565590031234 no 1025 0.292263906088166 1497 835267
SGTC_2531 methyl deoxycholate 70.07 µM 0.545949594489131 0.302854026981262 no 1026 0.292550293036102 1388 16667744 Haematoxylin.
SGTC_2680 butyl paraben 22.24 µM 0.545597330763562 0.302975978017707 no 1027 0.292671379787492 1432 7184 An antifungal and steroid mimetic.
SGTC_2072 5231554 129 µM 0.545469692196737 0.303020170947183 no 1028 0.292715259875162 1479 789545
SGTC_3272 9137413 49.47 µM 0.545178535278385 0.303120990432826 no 1029 0.292815366376231 1333 17614870
SGTC_326 k292-0812 17.5 µM 0.544691410572521 0.303289701614928 no 1030 0.292982886679476 1426 3579357
SGTC_2933 9026794 32.47 µM 0.5441257775056 0.303485656097173 no 1031 0.293177461481448 1465 17586027
SGTC_141 0443-0274 32.331 µM 0.543745236060287 0.303617520375421 no 1032 0.293308399443569 1469 1627241
SGTC_3037 9091026 49.47 µM 0.54146009629812 0.304409898721598 no 1033 0.294095247334874 1437 25236398 YIL048W NEO1
SGTC_511 blebbistatin 171 µM 0.541199827360629 0.304500206037287 no 1034 0.294184928240076 1484 3476986 A myosin inhibitor.
SGTC_344 k064-0035 6.43 µM 0.540304097461677 0.304811094714617 no 1035 0.294493666547391 1383 5088750
SGTC_2744 captopril 92.04 µM 0.540194256870859 0.304849227741507 no 1036 0.29453153646325 1500 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_368 fentichlor 4.58 µM 0.538989145834501 0.305267741650959 no 1037 0.294947172019612 1383 7329 A pesticide.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.537418584805995 0.305813552175883 no 1038 0.29548925433915 1431 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_692 k241-0027 77.8 µM 0.537307001543376 0.305852346677258 no 1039 0.295527784955027 1514 3600480
SGTC_2405 ticlatone 3.52 µM 0.537171301794387 0.305899528768456 no 1040 0.295574646304483 1299 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_202 3594-0513 34.79 µM 0.536957439931495 0.305973893955621 no 1041 0.295648506399976 1416 708429
SGTC_806 3966-4455 5.86 µM 0.536219632811106 0.306230509563131 no 1042 0.295903383191504 1361 714982
SGTC_177 1327-0068 8.361 µM 0.534786328248786 0.306729296836995 no 1043 0.296398809006293 1414 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2699 st077704 54.6 µM 0.534530750758154 0.306818274965924 no 1044 0.296487190026383 1455 645852
SGTC_2808 7946468 45.46 µM 0.534505298972551 0.306827136511436 no 1045 0.296495992146449 1475 2970879
SGTC_2900 5328528 85.29 µM 0.532570644638566 0.3075010550095 no 1046 0.297165413656971 1394 795359
SGTC_1972 st070201 17.4 µM 0.530886484211119 0.308088245920257 no 1047 0.29774872215637 1486 2829099
SGTC_1197 1601-0112 267 µM 0.52949310085538 0.308574427659957 no 1048 0.298231714565789 1417 7350313
SGTC_364 0083-0097 67.7 µM 0.528696857173054 0.308852405223614 no 1049 0.298507878863987 1465 5207356
SGTC_556 4058-0063 51.5 µM 0.528395137407259 0.308957767588907 no 1050 0.298612555892115 1472 6615692
SGTC_3052 9092717 49.47 µM 0.526650245380895 0.309567402562148 no 1051 0.299218246457197 1433 25237534
SGTC_2877 9040724 71.43 µM 0.521563981971963 0.311347441966654 no 1052 0.300986973332526 1532 6463895
SGTC_3227 9130768 49.47 µM 0.520717567135916 0.311644091801411 no 1053 0.301281767442671 1471 17720899
SGTC_3206 9114350 49.47 µM 0.518569332501526 0.312397549634729 no 1054 0.302030549791678 1408 17087243
SGTC_3200 9114385 49.47 µM 0.517407611930631 0.312805331224374 no 1055 0.302435823569325 1409 17018030 YLR208W SEC13
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.516840515190797 0.313004474083858 no 1056 0.302633747489356 1368 4000243
SGTC_3088 9117578 49.47 µM 0.516411238601053 0.313155256026767 no 1057 0.302783609022493 1485 678341
SGTC_473 2-arachidonoylglycerol 10 µM 0.516160926363564 0.313243191773478 no 1058 0.302871008988518 1432 5282280 An endocannabinoid.
SGTC_3012 9080433 71.4286 µM 0.515794145022943 0.313372062789888 no 1059 0.302999096142459 1531 17688859
SGTC_2242 6630449 61.2675 µM 0.515689042445699 0.313408995467536 no 1060 0.303035804467515 1471 691249 YDR170C SEC7
SGTC_2897 9048598 12.99 µM 0.515150526485272 0.313598257437557 no 1061 0.303223918778583 1425 6467404
SGTC_3092 9117248 49.47 µM 0.51489001235067 0.313689833006148 no 1062 0.303314940269722 1544 17141857
SGTC_1646 st011709 75.6 µM 0.514834353652831 0.313709399563364 no 1063 0.303334388543101 1499 5757843
SGTC_1306 1185-0270 9.02 µM 0.511461449799659 0.314896104661474 no 1064 0.304513987818762 1508 1548076
SGTC_1999 st074831 12.5 µM 0.511384142222142 0.314923326639802 no 1065 0.304541048364945 1430 17112523
SGTC_3308 9128332 17.569 µM 0.510688139763604 0.315168452195215 no 1066 0.304784723439428 1570 17332805 YDL196W YDL196W
SGTC_3322 9139058 2.11 µM 0.510446050980716 0.315253732687519 no 1067 0.304869500637491 1521 4908926 YPR165W RHO1
SGTC_980 1473-0395 201 µM 0.509476083086837 0.315595521496166 no 1068 0.30520927924961 1421 768876
SGTC_1360 1598-0022 39.8 µM 0.507518846842928 0.316285675537897 no 1069 0.305895407929398 1548 761525
SGTC_1895 st058434 18.3 µM 0.506516489853574 0.316639371425859 no 1070 0.306247058319704 1534 5393175
SGTC_1931 st074438 57.1 µM 0.505875298358644 0.316865712925463 no 1071 0.306472097038018 1436 2787313
SGTC_613 3914-0030 117 µM 0.505675613143109 0.316936216092041 no 1072 0.306542195388585 1397 1145395
SGTC_482 fipronil 114 µM 0.504404447035148 0.317385184433246 no 1073 0.306988596836258 1491 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1256 0570-0116 285 µM 0.504027671490435 0.317518311000913 no 1074 0.307120965929723 1446 410638
SGTC_3013 9080133 71.4286 µM 0.503855279457978 0.317579230361901 no 1075 0.307181539223684 1544 17050193
SGTC_1469 k284-2957 126 µM 0.503631429594101 0.317658341103439 no 1076 0.30726020107939 1511 23884841
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.503577389012158 0.31767744082394 no 1077 0.307279192513629 1446 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1852 st056254 31.4 µM 0.502150180382801 0.31818203883077 no 1078 0.307780942127728 1516 442583
SGTC_135 0933-0004 26.348 µM 0.501983678882719 0.318240928424435 no 1079 0.307839500857824 1420 21230617 YGL099W LSG1
SGTC_770 0389-1121 67.2 µM 0.500221883357688 0.318864335737267 no 1080 0.308459425622879 1576 6753108
SGTC_768 0384-0033 77.3 µM 0.499915994551018 0.318972626090647 no 1081 0.30856711475293 1443 3965305 YMR134W ERG29
SGTC_2317 5986382 200 µM 0.499854502273129 0.318994397371934 no 1082 0.308588765293875 1603 877883
SGTC_3020 9089140 49.47 µM 0.49967012660037 0.319059679142871 no 1083 0.308653685288264 1488 17217859
SGTC_1456 k015-0012 13 µM 0.499569111936679 0.319095447717052 no 1084 0.308689255810788 1641 2989616
SGTC_2041 5107442 45.335 µM 0.499436699020843 0.319142336740096 no 1085 0.308735885389698 1554 793005
SGTC_496 calpeptin 138 µM 0.499065757815107 0.319273706935219 no 1086 0.308866529791587 1427 73364 A calpain inhibitor.
SGTC_1088 bifonazole 369 nM 0.49897504508629 0.319305836636529 no 1087 0.308898482229216 1445 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2756 carbadox 75.1 µM 0.49570318647216 0.320465607576384 no 1088 0.310051919297555 1462 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1476 4112-3294 3.34 µM 0.495311285818106 0.320604641967948 no 1089 0.310190202825194 1562 704369
SGTC_925 2064-1272 59.6 µM 0.493670560247099 0.32118699445965 no 1090 0.310769429902748 1461 6815817
SGTC_1397 3532-0190 20.1 µM 0.488759777966511 0.322932632394414 no 1091 0.312505888562575 1510 5322280
SGTC_2035 5154463 94.595 µM 0.487781003603112 0.32328102604544 no 1092 0.31285248413001 1554 2769623
SGTC_1506 4226-2149 212 µM 0.487160734184551 0.323501890536192 no 1093 0.313072214556368 1540 991114
SGTC_960 1222-0186 7.7 µM 0.487134225540248 0.323511331076071 no 1094 0.313081606723078 1582 3126296
SGTC_784 4579-0127 173 µM 0.486779071682488 0.323637823193653 no 1095 0.313207451494134 1625 1948547
SGTC_1421 4029-0249 71.4 µM 0.485796922809971 0.323987732838519 no 1096 0.31355557813572 1604 2894095
SGTC_3276 9139060 49.47 µM 0.485132882787977 0.324224398190819 no 1097 0.313791043961291 1523 4870619
SGTC_1044 1222-0021 1.78 µM 0.484114236507293 0.324587584057401 no 1098 0.314152399116962 1531 4306703
SGTC_2641 levomentholum 100 µM 0.483289058975178 0.32488191337107 no 1099 0.314445253751098 1484 16666
SGTC_1734 st037168 69.4 µM 0.483193160383492 0.324916126156651 no 1100 0.314479295639495 1495 708907
SGTC_2226 7298446 200 µM 0.483044983026018 0.324968992820475 no 1101 0.31453189844027 1564 3283010
SGTC_2878 9043973 25.97 µM 0.482506728056658 0.325161060882453 no 1102 0.314723010042606 1576 6465167
SGTC_353 1988-1175 58.3 µM 0.482362553994638 0.325212515085297 no 1103 0.314774208592452 1432 2788357
SGTC_468 gf-109203x 121 µM 0.482323462155622 0.325226467124924 no 1104 0.314788091352728 1514 2396 A protein kinase C inhibitor.
SGTC_1400 3771-8998 51.5 µM 0.480966348371695 0.325710978448998 no 1105 0.315270207958947 1545 670767
SGTC_408 cantharidin 100 µM 0.480442741078059 0.325897993421124 no 1106 0.315456304391152 1517 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1203 3992-3522 103 µM 0.479345186261942 0.326290145331062 no 1107 0.315846540674352 1737 5322312
SGTC_1572 epiandrosterone 68.9 µM 0.478672180808447 0.326530702517543 no 1108 0.316085929765754 1527 441302 A steroid.
SGTC_2929 9013348 24.6 µM 0.478574161130069 0.326565744419119 no 1109 0.316120801955456 1508 2995952
SGTC_120 rhodamine 6G 52.259 µM 0.477234313573079 0.327044891414296 no 1110 0.316597639712989 1485 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.474533162020869 0.328011725063267 no 1111 0.317559877911455 1484 5355888
SGTC_515 4092-1064 102 µM 0.474375309870981 0.328068261434601 no 1112 0.317616148212853 1646 717353
SGTC_1741 st038134 10.228 µM 0.474283368013973 0.328101193172085 no 1113 0.317648925102852 1637 1272587
SGTC_2984 9022109 38.96 µM 0.474059794142453 0.328181278443946 no 1114 0.31772863422233 1564 6459207
SGTC_270 tamoxifen 5.46 µM 0.473297884795257 0.328454257460694 no 1115 0.318000335497095 1632 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1911 st060208 74.3 µM 0.471704472988121 0.329025445465985 no 1116 0.318568871982521 1610 688783
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.471659637035087 0.329041523528684 no 1117 0.31858487584066 1669 1273210
SGTC_2263 7948595 193.29 µM 0.468012182544251 0.330350548892406 no 1118 0.319887938868492 1514 2971371
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.467424188287999 0.330561767588916 no 1119 0.320098210143878 1551 688664
SGTC_2401 5128683 200 µM 0.466682887344541 0.330828133874699 no 1120 0.320363387433483 1445 708373
SGTC_1370 2001-0092 44.6 µM 0.465823949230063 0.331136877017258 no 1121 0.320670760494837 1694 790957
SGTC_935 2996-0153 430 µM 0.465089799737668 0.331400856244277 no 1122 0.320933575156222 1606 23738523
SGTC_1131 3454-3128 32.3 µM 0.464513896115006 0.331607993418594 no 1123 0.321139802960122 1635 710982
SGTC_329 k048-0121 21.3 µM 0.463987223263894 0.33179746868861 no 1124 0.321328449809719 1533 6832902
SGTC_743 1275-0778 158 µM 0.462925515916118 0.332179558180102 no 1125 0.321708878642373 1627 2849257 YMR203W TOM40
SGTC_3138 9097216 49.47 µM 0.462515338732922 0.332327220374448 no 1126 0.321855902605041 1505 25237486
SGTC_2937 9044753 11.33 µM 0.459493310404058 0.333415939955467 no 1127 0.32293997741284 1488 6465530 YGL099W LSG1
SGTC_728 3030-5151 22.5 µM 0.459172875183416 0.333531462865806 no 1128 0.323055013761601 1560 3125388
SGTC_435 c-PAF 6.7 µM 0.458008906470092 0.333951228192787 no 1129 0.323473021259108 1541 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1199 1638-0010 4.46 µM 0.457913204681649 0.33398575065325 no 1130 0.323507399859479 1517 3111136
SGTC_2826 7992541 19.48 µM 0.457769231290223 0.334037688752532 no 1131 0.323559121727769 1586 2985066
SGTC_2164 5685496 200 µM 0.456659128146514 0.334438262816814 no 1132 0.323958036278492 1599 759046
SGTC_1594 piperine 70.1 µM 0.45606457420304 0.334652881618141 no 1133 0.324171771899431 1500 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1509 1326-1131 80 µM 0.454185734864433 0.335331449563517 no 1134 0.324847574747827 1597 768313
SGTC_2481 5478948 45.16 µM 0.454080887305299 0.3353693325186 no 1135 0.324885304554568 1528 77792
SGTC_2958 9077254 16.72 µM 0.454036708081093 0.335385295619154 no 1136 0.324901203160192 1542 16457351
SGTC_1445 4239-0156 97.7 µM 0.453505606858585 0.335577219532311 no 1137 0.325092353445945 1688 4008346
SGTC_2532 xanthone 78.9 µM 0.45255936226293 0.335919269996039 no 1138 0.325433033341781 1612 7020 An insecticide.
SGTC_1724 st037281 8.293 µM 0.451381245564769 0.336345328050388 no 1139 0.32585739890744 1523 574124 YDL195W SEC31
SGTC_3117 9124945 49.47 µM 0.451056654669515 0.336462751152667 no 1140 0.325974358416488 1443 17592065
SGTC_1086 cerivastatin 2.18 µM 0.450699526468506 0.336591963290322 no 1141 0.326103061845806 1570 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_323 4013-0906 34.3 µM 0.450215815687299 0.33676700488919 no 1142 0.32627741669242 1635 2910086
SGTC_1764 st044502 93.5 µM 0.447317057334726 0.33781672552073 no 1143 0.327323076437217 1544 8407
SGTC_94 0334-0113 514.748 µM 0.447120958806369 0.337887783915929 no 1144 0.327393863501316 1494 6795178
SGTC_2153 5569715 200 µM 0.446804897306649 0.338002324334203 no 1145 0.327507967505279 1578 2054701
SGTC_1482 3346-2049 8.48 µM 0.446390846042215 0.338152398854652 no 1146 0.327657471995138 1596 3826804
SGTC_1524 corynanthine 62.1 µM 0.444470221698588 0.33884887280132 no 1147 0.328351326821337 1609 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_428 3448-4153 16.5 µM 0.443291343958648 0.339276641179128 no 1148 0.328777507993521 1488 3834874
SGTC_1328 1441-0025 69.2 µM 0.442534600847757 0.339551342742353 no 1149 0.329051198886393 1467 4562601
SGTC_1308 1187-1617 41.4 µM 0.441448423548779 0.339945779569749 no 1150 0.329444196258348 1557 2882570
SGTC_466 geldanamycin 89.2 µM 0.441230939421969 0.340024778311313 no 1151 0.329522908364932 1599 5288382 HSP90 inhibitor.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.440178581086083 0.340407135195536 no 1152 0.329903885761023 1660 756377
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.438268603616107 0.34110151273014 no 1153 0.330595791262149 1542 688667
SGTC_1880 MG-132 525 µM 0.436234466480796 0.341841621013972 no 1154 0.331333311752037 1649 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3315 9136395 68.55 µM 0.435495847516071 0.34211051366712 no 1155 0.331601276225365 1659 16876844
SGTC_596 1155-0152 116 µM 0.434930186267741 0.342316495595022 no 1156 0.331806551456341 1560 280313
SGTC_2358 9037157 4 µM 0.434918890963478 0.342320609185855 no 1157 0.331810650972173 1613 2388925
SGTC_1621 st003705 32.4 µM 0.43445223818317 0.342490573907477 no 1158 0.331980035451983 1678 24207032
SGTC_3318 9139014 38.6185 µM 0.434019888827977 0.342648073073122 no 1159 0.33213699920953 1577 16643984
SGTC_818 4072-2707 53.5 µM 0.433749747034805 0.342746496053501 no 1160 0.332235088719394 1510 882871
SGTC_1531 st059297 52.4 µM 0.43059612007874 0.343896271061809 no 1161 0.333381031414354 1594 7566702
SGTC_898 1000-0849 28.3 µM 0.429982589107539 0.344120125431453 no 1162 0.333604153197545 1604 6751807
SGTC_669 0108-0021 26.2 µM 0.429317807594125 0.344362740868643 no 1163 0.333845979628344 1844 17201
SGTC_2091 4-phenylthiadiazole 200 µM 0.428830687151873 0.344540558655238 no 1164 0.334023222422503 1599 270010
SGTC_2067 5224629 34.075 µM 0.428794343213006 0.344553826975338 no 1165 0.334036447949514 1549 2835000
SGTC_832 4083-0019 164 µM 0.428097346888094 0.344808320982233 no 1166 0.334290124153727 1726 1990758
SGTC_2683 piperine 63.03 µM 0.427759719593572 0.344931623968901 no 1167 0.334413032958564 1578 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1859 st055998 20 µM 0.427517106395528 0.345020237556114 no 1168 0.334501364085257 1730 676301
SGTC_2466 5983409 37.09 µM 0.427058790326211 0.345187659023663 no 1169 0.334668253769044 1575 2879657
SGTC_68 0986-0284 82.829 µM 0.425844707647746 0.345631306125531 no 1170 0.335110503596511 1508 423278 YIL048W NEO1
SGTC_2616 abietic acid 100 µM 0.425468998797138 0.345768639730219 no 1171 0.335247408163747 1673 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2619 obliquin 87.91 µM 0.425015600345404 0.345934398394555 no 1172 0.335412651189956 1674 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2589 lobaric acid 100 µM 0.424924870253033 0.345967572100862 no 1173 0.335445721989279 1537 73157 A novel microtubule depolymerizer.
SGTC_1660 st012960 28.1 µM 0.424304751465002 0.346194338205355 no 1174 0.33567178723108 1582 24207266
SGTC_391 gliotoxin 8.33 µM 0.423417857489028 0.346518754957363 no 1175 0.335995209137056 1650 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_938 3126-1755 342 µM 0.423312164370127 0.346557423934031 no 1176 0.336033760146719 1629 1777771
SGTC_967 1306-0166 352 µM 0.421252884203278 0.34731115260163 no 1177 0.336785215519771 1712 4437607
SGTC_1688 st021091 57.6 µM 0.420222583059709 0.347688485878587 no 1178 0.337161429365753 1704 3656366
SGTC_2957 9076800 11.52 µM 0.41691299662171 0.348901594812676 no 1179 0.338371023444722 1559 16459615
SGTC_1922 5578187 25 µM 0.415852611674258 0.349290600162001 no 1180 0.338758928802814 1701 1350412
SGTC_1127 asiatic acid 681.4 nM 0.414458407681612 0.349802308981365 no 1181 0.339269210677222 1566 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1964 st076914 61 µM 0.41388655653148 0.350012272091329 no 1182 0.339478594860807 1598 24208661
SGTC_2795 7780010 54.55 µM 0.411568886951589 0.350863705787407 no 1183 0.340327720078047 1615 953673
SGTC_2775 cyproheptadine 69.59 µM 0.410887818659514 0.35111404999497 no 1184 0.34057739747062 1632 2913 A selective serotonin reuptake inhibitor.
SGTC_868 0527-0199 213 µM 0.409820976236581 0.351506325302766 no 1185 0.340968638815404 1614 2849450
SGTC_2277 7947813 106.88 µM 0.40957499146428 0.351596795750615 no 1186 0.341058872687482 1713 1246798
SGTC_2111 5486399 200 µM 0.409368469889079 0.351672758567749 no 1187 0.341134637411619 1591 689674
SGTC_2987 9018338 71.43 µM 0.408771659127941 0.351892310929048 no 1188 0.341353620033762 1628 5055682
SGTC_2385 9074692 200 µM 0.408229185778423 0.352091916716174 no 1189 0.341552711454097 1580 17046906
SGTC_1738 st035555 74 µM 0.408048289643654 0.352158487420299 no 1190 0.34161911137575 1620 5331140
SGTC_2543 pimpinellin 60.67 µM 0.406009902937487 0.352908936905436 no 1191 0.342367662065538 1564 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2939 9044578 71.43 µM 0.405156346114345 0.353223351400431 no 1192 0.342681295445061 1568 2653634
SGTC_2102 5377816 72.7585 µM 0.404164314729713 0.35358890002373 no 1193 0.343045946610515 1744 1379702
SGTC_1781 st038725 66.3 µM 0.403950314383885 0.353667773649905 no 1194 0.3431246281012 1615 4270275 YIL048W NEO1
SGTC_1394 3474-0001 65.7 µM 0.403714900423211 0.353754546900756 no 1195 0.34321119059084 1590 5017666 YIL048W NEO1
SGTC_3103 9120822 49.47 µM 0.40367755998292 0.353768311232228 no 1196 0.343224921549959 1712 17141819
SGTC_616 4092-0450 108 µM 0.402866502717734 0.354067328095185 no 1197 0.343523217448034 1653 787165
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.401619388066162 0.354527284159303 no 1198 0.343982079489803 1649 66535 A nucleotide analog.
SGTC_3007 9078383 71.4286 µM 0.40064196526605 0.354887921885852 no 1199 0.344341872118969 1616 6496995
SGTC_54 0159-0055 9 µM 0.40041661468367 0.354971087499801 no 1200 0.344424844429363 1728 3319099
SGTC_563 tetrahydrosecaminediol 614 µM 0.398330333980561 0.355741356896667 no 1201 0.345193351620361 1729 334274 A psychoactive constituent of the cannabis plant.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.397828909173698 0.35592657440476 no 1202 0.345378152963106 1602 6312947
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.39769229005835 0.355977045001489 no 1203 0.34542851066592 1621 6708784 An antioxidant flavonoid
SGTC_1454 4239-0054 42.6 µM 0.396710849814598 0.356339688284132 no 1204 0.345790349180038 1715 1340767
SGTC_2208 7283366 200 µM 0.396481723733996 0.356424369353278 no 1205 0.345874843945054 1721 898663
SGTC_2440 5628896 157.78 µM 0.396038725420692 0.35658811400339 no 1206 0.346038230082342 1648 5522048
SGTC_2240 6690706 185.951 µM 0.394867201455067 0.357021269574361 no 1207 0.346470448306995 1546 805876
SGTC_501 nsc-95397 161 µM 0.393776162176088 0.357424832816231 no 1208 0.346873152636281 1716 262093
SGTC_2126 5251174 33.877 µM 0.391545532463424 0.358250413810133 no 1209 0.34769701973413 1826 790722
SGTC_288 1315-0019 35.1 µM 0.388270252424192 0.359463832450679 no 1210 0.348908024474598 1652 6811474
SGTC_535 2293-4129 48.2 µM 0.387631589865788 0.35970060841891 no 1211 0.349144343981221 1748 396118 YIL048W NEO1
SGTC_1839 st053978 48 µM 0.387255800917283 0.359839952537545 no 1212 0.34928342168986 1668 3788398
SGTC_49 0717-0965 32.132 µM 0.386291342479032 0.360197663003349 no 1213 0.349640455782879 1708 5889349 YGL099W LSG1
SGTC_2922 7999257 32.47 µM 0.386226806380303 0.360221603336407 no 1214 0.349664351235354 1606 2988377
SGTC_991 3996-0057 64.7 µM 0.385278348671745 0.360573506708213 no 1215 0.350015600494 1655 715343
SGTC_1670 st016595 4.04 µM 0.381803622600354 0.361863730720829 no 1216 0.351303515764093 1669 597879
SGTC_373 0844-0104 25.9 µM 0.380485763383316 0.36235348582095 no 1217 0.351792431257881 1776 5375804
SGTC_2005 4024620 188 µM 0.380268111213555 0.362434393450705 no 1218 0.351873202129025 1639 236743
SGTC_2480 5767542 37.17 µM 0.380118779810564 0.362489907822504 no 1219 0.351928622983376 1709 2867358
SGTC_1650 st011916 45.8 µM 0.379839058883507 0.362593902648749 no 1220 0.352032443321944 1757 242528
SGTC_260 nsc-65238 3.989 µM 0.379081193947692 0.362875713086168 no 1221 0.352313785498127 1717 3246252
SGTC_1609 st001574 46.4 µM 0.378152147815753 0.36322127820945 no 1222 0.352658785540366 1624 3960012
SGTC_1719 st032227 49.2 µM 0.378009210265658 0.363274454709977 no 1223 0.352711875975801 1599 3125804
SGTC_2881 9058953 51.95 µM 0.377156698190576 0.363591666157664 no 1224 0.353028578958179 1579 17122249
SGTC_3072 9116419 49.47 µM 0.376735971494706 0.363748248953836 no 1225 0.353184913879153 1613 17170162
SGTC_3190 9110366 49.47 µM 0.375835939432715 0.364083292290857 no 1226 0.353519433744105 1801 17123768
SGTC_2534 helenine 20.12 µM 0.375318410268837 0.364275993275505 no 1227 0.353711837917444 1649 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1247 0448-0043 5.84 µM 0.375015070714133 0.364388957126698 no 1228 0.353824629221294 1661 3089013 YGL099W LSG1
SGTC_3355 9151058 44.0485 µM 0.374228713656442 0.364681851844191 no 1229 0.354117081535418 1664 17015728
SGTC_2424 5537928 59.2 µM 0.371648777361924 0.365643355699482 no 1230 0.355077183565014 1618 5382802
SGTC_2853 9015042 58.44 µM 0.369557037837587 0.366423536344809 no 1231 0.35585628352739 1581 6457456
SGTC_255 tunicamycin 200.472 nM 0.368234581798047 0.366917073522653 no 1232 0.356349163296052 1787 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1864 st057645 30.4 µM 0.367348890547528 0.367247734300885 no 1233 0.35667939497716 1734 688666
SGTC_386 1509-0011 3.07 µM 0.366272322946886 0.367649788750279 no 1234 0.357080939944679 1658 3107280
SGTC_1779 st039427 55 µM 0.365057011186029 0.36810383286273 no 1235 0.357534424859577 1857 1124498
SGTC_2588 indole-3-carbinol 100 µM 0.364870941986091 0.368173365158164 no 1236 0.357603873032472 1818 3712 Induces cell cycle arrest.
SGTC_2649 anisomycin 9.56 µM 0.364574953452192 0.368283982164372 no 1237 0.357714357038216 1686 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2298 7976326 193.81 µM 0.363230734754167 0.368786481632093 no 1238 0.358216265116077 1716 2235818
SGTC_1420 4'-methoxyflavone 42 µM 0.362896708381989 0.368911383116853 no 1239 0.358341022856261 1797 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_86 0417-1630 471.922 µM 0.362829959391308 0.368936344028008 no 1240 0.358365955195948 1708 3634867
SGTC_928 2764-0428 58.7 µM 0.359952088693235 0.370013053620267 no 1241 0.359441481482215 1729 662578
SGTC_416 estradiol valerate 100 µM 0.359490919689256 0.370185687680155 no 1242 0.359613934744692 1705 13791 A steroid.
SGTC_1263 0774-1208 64.8 µM 0.359078742391726 0.3703400043145 no 1243 0.359768091851477 1821 906585
SGTC_1348 1493-0373 93.8 µM 0.358092095773886 0.370709483442538 no 1244 0.360137197022128 1720 3010129
SGTC_1600 coumarin 106 71.1 µM 0.355763296855516 0.371582043786111 no 1245 0.361008918971261 1729 100336 A hepatotoxic, DNA x-linker.
SGTC_724 3910-0327 137 µM 0.354847226986117 0.371925460383181 no 1246 0.361352022817505 1638 2885483
SGTC_1794 st048918 76.9 µM 0.354732851947788 0.371968344500411 no 1247 0.361394868562451 1815 672303
SGTC_771 0250-0039 27.3 µM 0.354369844505251 0.372104462109212 no 1248 0.3615308653779 1702 3005115
SGTC_1331 1472-0049 76.2 µM 0.353769281857222 0.372329691345818 no 1249 0.361755898092169 1653 24051409
SGTC_1821 st053465 65.6 µM 0.353757461171467 0.372334124900601 no 1250 0.361760327820388 1676 675086
SGTC_3337 9144342 33.5465 µM 0.352125796588694 0.372946271347226 no 1251 0.362371961452015 1768 17682949
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.351794232834947 0.373070702357489 no 1252 0.362496291989864 1637 6708514
SGTC_74 000s-0487 160.283 µM 0.351332621392119 0.373243960404512 no 1253 0.362669412257524 1660 677548
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.350363031218982 0.373607963102986 no 1254 0.363033133520825 1763 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_36 0335-0881 14.2 µM 0.349702045980036 0.373856174278166 no 1255 0.363281159022444 1722 23828853
SGTC_2419 paclitaxel 166.5 µM 0.349586943510239 0.373899402560656 no 1256 0.363324355484856 1738 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1640 st009078 66.4 µM 0.348364778990789 0.374358500635537 no 1257 0.363783125073382 1781 690618
SGTC_2214 7179297 48.276 µM 0.347456921814935 0.374699646616828 no 1258 0.364124038146625 1763 769744
SGTC_2255 7941087 197.44 µM 0.3471002849204 0.374833687104445 no 1259 0.36425798972912 1830 935561
SGTC_144 4161-2749 112.381 µM 0.345046721595157 0.375605804075607 no 1260 0.365029623191746 1748 797501 YMR168C CEP3
SGTC_638 3970-0837 4.09 µM 0.344776035191605 0.375707616401343 no 1261 0.365131375397575 1665 4118451 YLR208W SEC13
SGTC_2710 st078562 53.7235 µM 0.344749815048704 0.375717478951445 no 1262 0.365141232168848 1659 17250908
SGTC_1407 3909-7909 12.3 µM 0.344474849894784 0.375820910341033 no 1263 0.365244603432679 1688 4411780
SGTC_1288 0973-0013 65.5 µM 0.342590065004635 0.376530134285763 no 1264 0.365953438617699 1747 4315430
SGTC_1516 st013856 110 µM 0.341933471762278 0.376777301202724 no 1265 0.366200479689409 1714 5281404 A mutagen and neurotoxin.
SGTC_1912 st060209 90.8 µM 0.341899829491954 0.376789966806796 no 1266 0.36621313897887 1645 688787
SGTC_1508 1080-0625 72.9 µM 0.340051800414561 0.377485914076832 no 1267 0.366908759354659 1726 767111
SGTC_1505 k297-0037 20.6 µM 0.339237829892841 0.377792572746668 no 1268 0.367215286492761 1680 4089396
SGTC_2343 7990716 14.84 µM 0.339023462184132 0.37787334736018 no 1269 0.367296027732745 1753 6456862
SGTC_1045 1348-1485 165 µM 0.33887982674526 0.377927472758289 no 1270 0.367350131064678 1707 6810614
SGTC_1653 st012112 65 µM 0.338252581640085 0.378163862350363 no 1271 0.367586427074164 1792 720429
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.337314472191061 0.37851749235999 no 1272 0.367939925560848 1747 165521
SGTC_2181 6316240 54.2555 µM 0.336365999828245 0.378875132229756 no 1273 0.368297442739244 1659 12779990
SGTC_1287 0971-0001 34.6 µM 0.335971424407001 0.379023945103328 no 1274 0.368446207617812 1767 4665869
SGTC_3307 9126885 69.2785 µM 0.332058423619309 0.380500688393909 no 1275 0.369922571841552 1659 24824909
SGTC_1102 cgs 12066b 26.1 µM 0.326994852392969 0.382414235007454 no 1276 0.371835889295339 1762 6438352 A 5-HT1B full agonist.
SGTC_886 0866-0150 153 µM 0.32556155308457 0.382956409443849 no 1277 0.372378052424206 1878 271463
SGTC_1936 st074407 74.3 µM 0.324170856706906 0.383482687754575 no 1278 0.372904342355451 1682 809813
SGTC_2728 chlorpromazine 9.18 µM 0.32412349141096 0.383500615896404 no 1279 0.372922271284908 1777 2726 A thorazine and dopamine antagonist.
SGTC_335 4077-0256 27.6 µM 0.323732634335805 0.383648567931507 no 1280 0.373070230804874 1827 3121989
SGTC_3255 9139072 49.47 µM 0.322558797703488 0.384093004936295 no 1281 0.373514700855244 1761 17646060
SGTC_1579 chlormadinone acetate 49.4 µM 0.318406627179253 0.385666315904996 no 1282 0.375088255953282 1872 45114258 A steroidal progestin.
SGTC_310 1273-0058 1.06 µM 0.316960809834102 0.386214598060612 no 1283 0.375636669688523 1771 2734232
SGTC_1014 4130-3005 69.3 µM 0.316469890888316 0.386400815854238 no 1284 0.375822937630519 1714 743608
SGTC_1996 st072960 66.8 µM 0.31575231354643 0.386673057894942 no 1285 0.376095257963573 1875 1719405
SGTC_1943 st076331 65.2 µM 0.315469126618235 0.386780511688661 no 1286 0.376202744285729 1903 24208415
SGTC_125 0133-0007 11.75 µM 0.31496447301669 0.386972021360712 no 1287 0.376394314213143 1929 26541
SGTC_2873 9040596 71.43 µM 0.314618527306005 0.387103319293354 no 1288 0.376525655144933 1702 6463863
SGTC_2176 5809774 33.9695 µM 0.313550700290655 0.387508676669489 no 1289 0.376931153934055 1897 2870539
SGTC_1270 0831-1170 17.3 µM 0.312529404542652 0.387896485101177 no 1290 0.377319109895458 1753 6764716
SGTC_540 1187-0821 17.3 µM 0.312483644177021 0.387913863937926 no 1291 0.377336495623463 1701 847520
SGTC_2335 9018011 154.17 µM 0.311861689884556 0.388150091513002 no 1292 0.377572819251404 1870 6458208
SGTC_151 3013-0144 2.285 µM 0.311839748793235 0.38815842582511 no 1293 0.37758115703334 1864 906558 YHR107C CDC12
SGTC_653 0203-0016 55.2 µM 0.311636175019655 0.388235755672411 no 1294 0.377658519338591 1798 295302
SGTC_1190 1486-1332 13 µM 0.31157203221655 0.388260121974603 no 1295 0.377682895966585 1720 4150046
SGTC_3239 9133757 49.47 µM 0.31145008807404 0.388306446822861 no 1296 0.377729240576187 1827 17036923
SGTC_1163 k060-0048 49.9 µM 0.310029480478753 0.388846232396371 no 1297 0.37826926897423 1752 6809982
SGTC_1785 bathophenanthroline 24 µM 0.309632476735112 0.388997119576326 no 1298 0.378420228166991 1712 72812 An iron chelator.
SGTC_920 mycophenolic acid 780.421 nM 0.309527462318527 0.389037034669053 no 1299 0.37846016261177 1724 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_755 1995-0008 37.3 µM 0.308588434251779 0.389394003315861 no 1300 0.378817309944964 1776 689533
SGTC_2013 4024628 200 µM 0.306071995144946 0.39035107946979 no 1301 0.379774914993012 1810 5230760
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.305663990805072 0.390506318367993 no 1302 0.379930246510786 1784 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3181 9108277 49.47 µM 0.305240210690931 0.390667578169251 no 1303 0.380091604541468 1735 17097298
SGTC_2518 prenyletin 46.28 µM 0.303646720309335 0.391274112475737 no 1304 0.380698526708247 1868 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_246 cycloheximide 667 µM 0.302216952542327 0.391818553806524 no 1305 0.381243340925104 1740 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2011 4012611 177 µM 0.302126295744064 0.391853082168491 no 1306 0.38127789372377 1716 2049887
SGTC_57 miconazole 162.5 nM 0.301976656462856 0.391910076991646 no 1307 0.381334929089385 1702 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_747 3448-8087 38.7 µM 0.301407764270464 0.392126778625042 no 1308 0.381551787207746 1742 5168703
SGTC_3066 9117245 49.47 µM 0.300369373963583 0.392522407073299 no 1309 0.381947710890222 1864 17176980
SGTC_1424 4048-1941 275 µM 0.299824099831291 0.392730201943792 no 1310 0.382155665761886 1904 X1424
SGTC_3303 9125618 40.5795 µM 0.2996101416116 0.392811746206567 no 1311 0.382237273741755 1862 22695467
SGTC_1925 st057770 10.1 µM 0.298050271349662 0.393406389617201 no 1312 0.382832397606353 1660 5989122
SGTC_913 3487-1245 167 µM 0.297069916383384 0.393780241421868 no 1313 0.383206565699041 1691 4016153
SGTC_2447 5741742 33.78 µM 0.297012248323184 0.393802235803446 no 1314 0.38322857903028 1833 1776504
SGTC_2281 7943571 200 µM 0.296395662816348 0.394037420362038 no 1315 0.38346396859031 1956 1244024
SGTC_883 0850-0245 24.6 µM 0.296182354064346 0.39411879184181 no 1316 0.383545412009238 1876 6823229 YPR165W RHO1
SGTC_361 000s-0510 1.45 µM 0.295892215536681 0.394229479206976 no 1317 0.383656198065139 1786 660
SGTC_1066 ketoconazole 628 nM 0.294959415382017 0.3945853987524 no 1318 0.38401244146649 1856 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_934 2950-0684 338 µM 0.29293388968398 0.395358561719644 no 1319 0.384786342145117 1898 1121253
SGTC_984 1492-0255 2.91 µM 0.291167852861986 0.396033011653641 no 1320 0.385461473805096 1810 1585198
SGTC_1160 4092-0570 10.5 µM 0.290101059465879 0.396440571309751 no 1321 0.385869462649442 1729 4994975
SGTC_971 1315-0384 26.7 µM 0.289262466303765 0.396761028422886 no 1322 0.386190266333164 1736 6769120
SGTC_1307 1187-1599 12.2 µM 0.28915709849279 0.396801298252564 no 1323 0.386230580280951 1780 1538471
SGTC_1855 st056195 39.6 µM 0.28905492156227 0.396840349631754 no 1324 0.386269674564183 1918 4028379
SGTC_1933 st074711 15.9 µM 0.288657329324527 0.396992316722251 no 1325 0.38642180974635 1843 17250958
SGTC_256 clotrimazole 625 nM 0.288594056995193 0.397016502017497 no 1326 0.386446021959211 1798 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1057 3448-5381 134 µM 0.288517428997885 0.397045792930461 no 1327 0.386475345533279 1897 5497911
SGTC_1216 1165-0504 9.65 µM 0.288026024773559 0.397233645101059 no 1328 0.386663408760233 1926 6304004
SGTC_2431 5490079 200 µM 0.286534945313599 0.397803795143934 no 1329 0.38723421621725 1758 5722345
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.286506487693666 0.397814678725536 no 1330 0.387245112594449 1802 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.283696665641586 0.398889681985253 no 1331 0.388321425113455 1811 521171
SGTC_2134 5324836 1.464 µM 0.283477344483516 0.398973623948674 no 1332 0.388405473091335 1826 699272
SGTC_943 3253-1379 105 µM 0.281542964005771 0.399714181690494 no 1333 0.389146989816639 1884 668464
SGTC_3121 9125696 49.47 µM 0.280704312692621 0.400035363061954 no 1334 0.389468600324901 1971 1235365
SGTC_2961 9083290 32.55 µM 0.280214562138897 0.400222955923316 no 1335 0.389656447530653 1818 17741490
SGTC_244 nsc-207895 1.295 µM 0.279189070647113 0.400615832219973 no 1336 0.390049865331709 1785 42640
SGTC_419 nsc-638432 893 µM 0.278817151834734 0.400758342997412 no 1337 0.39019257548562 1818 368090
SGTC_337 1315-0038 354 µM 0.278691790738319 0.400806381478165 no 1338 0.390240681527629 1812 1626437
SGTC_1158 4092-0494 91.8 µM 0.277138480661753 0.401401735472862 no 1339 0.390836887637297 1893 1148199
SGTC_1433 4060-0023 7.6 µM 0.276905771637048 0.401490948138449 no 1340 0.390926230350749 1874 3840627
SGTC_2515 chrysin 20.77 µM 0.276556177723359 0.401624980115125 no 1341 0.391060458865327 1901 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2832 7992762 51.95 µM 0.276549308098591 0.401627613999477 no 1342 0.391063096625777 1621 2985177
SGTC_2701 st077767 14.721 µM 0.276538312959947 0.401631829657316 no 1343 0.391067318488612 1805 5721188
SGTC_2368 9071271 200 µM 0.274323609342597 0.402481204276337 no 1344 0.391917971273713 1756 27209959
SGTC_1152 3909-8331 15.9 µM 0.274127062572196 0.40255660544756 no 1345 0.391993488600075 1816 16001939
SGTC_247 mechlorethamine 29.705 µM 0.273677238389466 0.402729184984757 no 1346 0.392166335644363 1848 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1372 2752-0194 270 µM 0.273407658009047 0.402832621274373 no 1347 0.39226993336541 1805 823334
SGTC_155 k072-0202 43.6 µM 0.272704601388555 0.403102411639973 no 1348 0.392540148666468 1939 5857737
SGTC_3115 9123671 49.47 µM 0.272124274101228 0.403325140715605 no 1349 0.392763232776135 1888 3286988
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.271112095673207 0.40371368887605 no 1350 0.393152409426526 1906 17037758
SGTC_2113 5491891 107.031 µM 0.270898337567575 0.403795757049453 no 1351 0.393234611833167 1749 789979
SGTC_3279 9140807 49.47 µM 0.269823937801077 0.404208315546167 no 1352 0.393647852965332 1829 45595718
SGTC_631 k072-0230 41.5 µM 0.267209809417533 0.405212558224362 no 1353 0.394653811924415 1886 5773147
SGTC_1530 rhein 70.4 µM 0.266554931649133 0.405464233912868 no 1354 0.394905929854719 1891 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_18 0111-0177 500 nM 0.265731818888037 0.405780619324704 no 1355 0.395222878099865 1844 721752
SGTC_2611 pyromycin 23.93 µM 0.264991337476047 0.406065295770332 no 1356 0.395508067520525 1769 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1183 1254-0324 198 µM 0.26481370751566 0.406133592609452 no 1357 0.395576488350123 1911 5799357
SGTC_290 2043-6722 48.1 µM 0.264207399238976 0.406366733225333 no 1358 0.395810054912511 1868 773758 YLR208W SEC13
SGTC_226 1,3-diallylurea 8.28947 mM 0.263551220076279 0.406619087843929 no 1359 0.396062875265834 1867 74537 YKL182W FAS1
SGTC_674 0498-0004 451 µM 0.263373505809655 0.406687440210284 no 1360 0.396131354618168 1797 4231473
SGTC_1829 berberine 14.4 µM 0.262802842660613 0.406906947577739 no 1361 0.396351272203581 1943 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2391 6285546 200 µM 0.262222304177699 0.407130283534543 no 1362 0.396575029310577 1795 846083
SGTC_2949 9072542 2.23 µM 0.260785671176028 0.407683092872689 no 1363 0.397128897470716 1796 16457352
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.26067214736858 0.407726784130465 no 1364 0.397172673406559 1908 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1682 st012968 530 nM 0.258470913404439 0.408574186680693 no 1365 0.398021747083765 1765 24207270
SGTC_2661 dactinomycin 12.96 µM 0.258228784593653 0.408667424473044 no 1366 0.398115172086327 1869 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_258 haloperidol 50.781 µM 0.257364626889228 0.409000232258895 no 1367 0.398448653504914 1802 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2960 9079389 5.97 µM 0.257229810661773 0.409052159133005 no 1368 0.39850068624355 1965 16457355
SGTC_1976 st070609 63.5 µM 0.254365317861913 0.410155845460137 no 1369 0.39960667114512 1893 682556
SGTC_965 1291-5240 308 µM 0.254311042243371 0.410176764705109 no 1370 0.39962763485043 1935 2834598
SGTC_1628 st004252 77.7 µM 0.254211103655188 0.410215284323197 no 1371 0.399666236422351 1955 692968
SGTC_842 0271-0008 11.1 µM 0.251689070323911 0.411187644716167 no 1372 0.400640702860339 1919 1221709
SGTC_1164 k060-0068 93.7 µM 0.251370864280999 0.411310366754453 no 1373 0.400763695794425 1865 5963676
SGTC_1846 st056244 14.8 µM 0.250300988792768 0.411723047577563 no 1374 0.401177295927784 1905 5393182
SGTC_1087 pterostilbene 9.05 µM 0.249135718820803 0.412172635820242 no 1375 0.401627900358276 1968 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1329 1447-1697 50.6 µM 0.24842167844266 0.412448186202254 no 1376 0.401904081107311 1883 2840515
SGTC_1723 st034307 2.5525 µM 0.248207768321278 0.412530743184669 no 1377 0.401986828069042 1839 867466
SGTC_1252 0493-0875 34.8 µM 0.246928144642013 0.413024684893758 no 1378 0.402481917180407 1831 3960963
SGTC_3238 9133470 49.47 µM 0.246509924184229 0.413186150167678 no 1379 0.402643761522726 1985 3534688
SGTC_2450 5739737 12.93 µM 0.245976574921354 0.413392085320511 no 1380 0.402850182997716 1870 2262825
SGTC_3254 9136651 49.47 µM 0.245507908048079 0.413573065182009 no 1381 0.403031592887993 1855 16454030
SGTC_3223 9129970 49.47 µM 0.24377106679552 0.414243921629869 no 1382 0.403704064891108 1882 17248386
SGTC_2781 5567276 71.43 µM 0.243258453936942 0.41444196671512 no 1383 0.403902593384997 1929 2853274
SGTC_2810 7959871 45.46 µM 0.242867163677835 0.414593154141335 no 1384 0.404054151830813 1933 2974535
SGTC_208 k072-0098 12.366 µM 0.241900751024558 0.414966612553766 no 1385 0.404428534090093 1951 5948901
SGTC_2053 5265679 138 µM 0.241436698335751 0.415145967403435 no 1386 0.404608336346473 1856 764595
SGTC_2994 9053520 71.4286 µM 0.240677328770428 0.415439499393842 no 1387 0.404902605775224 1974 4647384
SGTC_483 fpl-64176 144 µM 0.240385397510091 0.415552357101376 no 1388 0.405015748736131 1916 3423
SGTC_1090 efavirenz 20.7 µM 0.238044448933355 0.416457595573064 no 1389 0.405923309809782 1934 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_811 0416-0114 265 µM 0.236236874279517 0.417156883340023 no 1390 0.406624433799625 1870 6612453
SGTC_1953 st076800 12.1 µM 0.235843909183166 0.41730894263488 no 1391 0.406776897223223 1783 297591
SGTC_465 cgp-37157 41 µM 0.232982699186402 0.418416469888401 no 1392 0.40788742009159 2013 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_187 1488-2104 32.728 µM 0.232974169485782 0.41841977256676 no 1393 0.407890731839949 1976 2852859
SGTC_2666 tannic acid 100 µM 0.232746042024436 0.418508105071995 no 1394 0.407979307230858 1926 16134267 A thiamine antagonist.
SGTC_1072 oxiconazole 14.9 nM 0.232627452305105 0.41855402544193 no 1395 0.408025354096877 1914 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_406 estrone 100 µM 0.23251555092346 0.418597356968247 no 1396 0.408068805132099 2019 5870 A steroid.
SGTC_1302 1159-0335 255 µM 0.232114517331504 0.418752657151925 no 1397 0.408224534786171 1875 649284
SGTC_996 3970-0799 1.8 µM 0.231649797702487 0.41893263557914 no 1398 0.408405013179522 2008 6615648 YGL040C HEM2
SGTC_953 1188-0045 9.7 µM 0.23088140183071 0.419230260128407 no 1399 0.408703469804728 1921 6144426
SGTC_2991 9074669 71.4286 µM 0.230175054939076 0.419503891881539 no 1400 0.4089778723797 1958 17333109
SGTC_137 0438-0332 85.389 µM 0.230116070951374 0.419526743454085 no 1401 0.409000788577517 1965 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2043 5101342 149 µM 0.229452254644358 0.419783937819647 no 1402 0.409258712981407 1919 678451
SGTC_1169 aniline yellow 25.8 µM 0.221762494043639 0.422765791131059 no 1403 0.412249388944491 1961 6051 A DNA damaging agent.
SGTC_1754 st042065 16.137 µM 0.220409882464796 0.423290755500576 no 1404 0.412775974779904 1949 1126236 YIL048W NEO1
SGTC_809 3998-0021 90 µM 0.219768290851444 0.423539812393723 no 1405 0.413025808064163 2046 715485
SGTC_1113 artemisinin 1.17947 µM 0.218729340305318 0.423943183218256 no 1406 0.41343044604578 2040 2240 An anti-malaria and mitochondrial poison.
SGTC_877 0771-0151 33.1 µM 0.218092468729849 0.424190486978382 no 1407 0.413678532630204 1941 6166523
SGTC_1547 harmine 94.2 µM 0.217793104862293 0.42430674335658 no 1408 0.413795158569828 1949 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2856 9022925 19.48 µM 0.217668796009737 0.424355019979321 no 1409 0.4138435889496 1932 4944862
SGTC_3351 9150312 21.596 µM 0.216858595659463 0.424669697399669 no 1410 0.414159272802433 2025 4904905
SGTC_601 0986-0029 62.9 µM 0.21633613709212 0.424872642949991 no 1411 0.414362871305055 1923 24747981
SGTC_744 1594-0068 283 µM 0.21604198777996 0.424986912056476 no 1412 0.414477509393723 1895 668392
SGTC_1745 st081495 74 µM 0.215638732609309 0.425143576099901 no 1413 0.414634680878526 1924 13842402 YBL026W LSM2
SGTC_760 0568-0725 82.9 µM 0.215463332976418 0.425211722291243 no 1414 0.414703048362333 2044 3916171
SGTC_853 0419-0306 21 µM 0.212352342616025 0.426420772415521 no 1415 0.415916081465366 1878 762713
SGTC_2917 7979103 53.79 µM 0.212136385009234 0.426504727630123 no 1416 0.416000317243842 2003 2980565
SGTC_2452 5863136 48.41 µM 0.211233003122269 0.426855960489884 no 1417 0.416352729475355 1934 2184096
SGTC_1664 st014217 9.02 µM 0.210947172455869 0.426967102907077 no 1418 0.416464246973309 2061 3982782
SGTC_782 0083-0095 30.5 µM 0.210566339272333 0.427115195117606 no 1419 0.416612840370329 1938 3591729 An indicator and reagent.
SGTC_630 4356-0227 183 µM 0.209881697137617 0.427381453428756 no 1420 0.416880003822067 1980 779312
SGTC_906 1165-0455 526 µM 0.20977475081679 0.427423047997179 no 1421 0.416921740260001 1897 3252859
SGTC_602 3130-1533 38.1 µM 0.209547796678975 0.42751131980596 no 1422 0.417010313563819 2024 720941
SGTC_1356 1502-0781 85.8 µM 0.209188166089541 0.427651202378964 no 1423 0.417150675079611 1921 567702
SGTC_2330 7979373 200 µM 0.209090927564921 0.427689026016368 no 1424 0.417188628467343 1817 1863007
SGTC_1402 3909-7673 35.9 µM 0.20885783733763 0.427779695669353 no 1425 0.417279609580621 1956 5328014
SGTC_839 0122-0028 230 µM 0.208641164683975 0.427863982478953 no 1426 0.41736418646491 1956 759448
SGTC_1035 k081-0041 55.2 µM 0.208497100716911 0.427920025947193 no 1427 0.417420423095874 2058 731709
SGTC_2196 6573537 42.6665 µM 0.208476698713174 0.427927962810309 no 1428 0.417428387333247 2046 2903087
SGTC_331 k048-0133 24.5 µM 0.208245509452347 0.428017902950157 no 1429 0.417518637999169 1915 6813582
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.207550327776657 0.428288373738775 no 1430 0.417790046180136 1973 676296 Flavone; oxidizing agent.
SGTC_1244 0416-0015 52.5 µM 0.20753706221501 0.42829353523116 no 1431 0.41779522561319 1931 96201
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.207374823512433 0.428356661619015 no 1432 0.417858571577816 1882 688669
SGTC_2359 9039622 200 µM 0.207336234388672 0.428371676752579 no 1433 0.417873638982463 1981 6463596
SGTC_191 3914-0123 66.505 µM 0.207324287955074 0.428376325163576 no 1434 0.417878303578977 1914 3144412
SGTC_3150 9097574 49.47 µM 0.207275989506371 0.428395118408304 no 1435 0.417897162276888 2037 17217476
SGTC_2110 5483698 200 µM 0.206712294207863 0.428614467960727 no 1436 0.418117277691658 1925 2848765 YHR062C RPP1
SGTC_380 3970-0968 6 µM 0.206455043712774 0.428714578631316 no 1437 0.418217739069873 1914 2891601
SGTC_1126 isoteolin 1.0172 µM 0.206298251427769 0.42877559759897 no 1438 0.418278972158632 1876 133323
SGTC_2088 5278280 127.392 µM 0.205567435291263 0.429060032284379 no 1439 0.418564408542978 1961 791502
SGTC_1806 st050005 60.3 µM 0.203688937578903 0.429791314989122 no 1440 0.419298293752283 1891 5194765
SGTC_1518 st038567 90.8 µM 0.203087592511148 0.430025464388211 no 1441 0.419533284698094 2051 77966
SGTC_1961 st076550 68.7 µM 0.200889706936621 0.430881477270458 no 1442 0.420392408161706 1962 1579337
SGTC_2248 tofa 1.1 µM 0.200705899163386 0.430953079857314 no 1443 0.420464273357785 1929 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_297 0986-0032 24 µM 0.198158176761333 0.431945781576563 no 1444 0.421460654344856 1943 2847425
SGTC_2896 9052656 71.43 µM 0.197831997103891 0.432072906307011 no 1445 0.421588255415478 2016 6469436
SGTC_1012 4112-3522 18 µM 0.196511341402458 0.432587688274256 no 1446 0.422104978287106 2069 3112398
SGTC_2099 5377090 177.372 µM 0.196273908782446 0.432680249941411 no 1447 0.422197890984164 1938 2243829
SGTC_2803 7707263 71.43 µM 0.193168741830494 0.433891118680836 no 1448 0.423413409035594 1920 2199229
SGTC_2275 7947463 200 µM 0.19314862531783 0.433898965208143 no 1449 0.423421286037255 2085 1225414
SGTC_1446 4239-0190 62 µM 0.19282932026508 0.434023514924237 no 1450 0.423546320076595 1909 1340085
SGTC_753 1322-0200 289 µM 0.191282943535505 0.434626794776199 no 1451 0.424151961724814 1982 5403907
SGTC_2219 9098279 200 µM 0.190302572639574 0.435009340685391 no 1452 0.424536018907689 2064 902349
SGTC_1590 st077108 57.8 µM 0.189005446593073 0.43551557957882 no 1453 0.425044273983978 2074 5489485
SGTC_127 0180-0333 59.125 µM 0.187661175496592 0.436040329635853 no 1454 0.425571133471334 2097 771601
SGTC_1140 3229-1848 2.98 µM 0.18764104119949 0.436048190124184 no 1455 0.425579025708838 2083 2849525
SGTC_936 3005-4620 401 µM 0.187538898562491 0.43608806729673 no 1456 0.42561906401726 2098 777207
SGTC_59 0330-0160 1.33 µM 0.183793324603393 0.437550810024226 no 1457 0.427087796563205 2011 4293482
SGTC_2017 5132927 60.65 µM 0.183473836507085 0.437675618128043 no 1458 0.427213122875297 1966 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2819 7996655 46.38 µM 0.183191986608312 0.437785728009382 no 1459 0.427323690866942 2050 6456960
SGTC_2469 5655019 90.81 µM 0.182978093547806 0.437869292509423 no 1460 0.42740760361722 2064 2788239
SGTC_263 alizarin 107.927 µM 0.181834050007937 0.438316298455549 no 1461 0.427856480953422 2030 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1201 1889-3372 45.9 µM 0.181767366662492 0.438342355711566 no 1462 0.427882647740718 1977 5392199
SGTC_815 1582-0027 36.9 µM 0.181729388351542 0.438357196276808 no 1463 0.427897550709834 2020 3128206
SGTC_1094 duloxetine 25.4 µM 0.17874727836138 0.439522767146973 no 1464 0.429068072097751 1980 60834 A selective serotonin reuptake inhibitor.
SGTC_1022 4477-0945 21.3 µM 0.177790641275315 0.439896784573395 no 1465 0.429443698717708 1923 4648966
SGTC_2603 homopterocarpin 100 µM 0.177728340157899 0.439921144372208 no 1466 0.429468163670865 1966 101795 A weak amylase inhibitor.
SGTC_1947 st076332 61.6 µM 0.176455374609717 0.440418924837647 no 1467 0.429968102211993 2092 24208416
SGTC_2725 haloperidol 53.21 µM 0.17644719928887 0.440422122020414 no 1468 0.429971313313099 2080 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3010 9080089 71.4286 µM 0.176298393137443 0.440480317413523 no 1469 0.430029762176733 2085 17027233
SGTC_1065 prochlorperazine maleate 2.48 µM 0.176223876541847 0.440509459988822 no 1470 0.430059031773755 2065 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3283 9109332 35.8195 µM 0.175332998650378 0.440857896899004 no 1471 0.430408992093764 2052 17027281
SGTC_3032 9089427 49.47 µM 0.174308987747899 0.441258460858404 no 1472 0.430811318086461 1990 17173707
SGTC_3040 9091894 49.47 µM 0.174003385476817 0.441378015442834 no 1473 0.430931400797399 2066 25236966
SGTC_119 0121-0043 24.815 µM 0.173869486540546 0.441430399694245 no 1474 0.430984016775124 2116 1092378
SGTC_946 3434-1334 87.4 µM 0.17287405477127 0.441819866873013 no 1475 0.431375212935579 2050 4047976
SGTC_2305 7443522 69.23 µM 0.171428678866065 0.44238547677187 no 1476 0.4319433530363 2026 5415886
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.1712743562543 0.442445873833331 no 1477 0.432004021625459 2140 16623 A steroid.
SGTC_2698 st077697 67.5 µM 0.169844388900978 0.44300558194148 no 1478 0.432566258377092 1949 3154499
SGTC_1311 1190-0148 100 µM 0.169803707655176 0.443021506787748 no 1479 0.432582255494726 2072 1961333
SGTC_1899 st063254 59.6 µM 0.168786277713929 0.443419813925681 no 1480 0.432982376129575 1939 3093813
SGTC_1274 0865-0114 173 µM 0.168394521073734 0.443573195493684 no 1481 0.433136459054399 2014 870624
SGTC_2029 5175081 200 µM 0.166303724271842 0.444391932043508 no 1482 0.433958967657722 2086 1380876
SGTC_1121 fusaric acid 630.51 nM 0.164705201580776 0.445018058924743 no 1483 0.43458801131595 1949 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2552 juarezic acid 87.02 µM 0.16421450590091 0.445210287578303 no 1484 0.434781141033409 2158 1549512
SGTC_2249 haloperidol 116.36 µM 0.164112554464307 0.445250228385042 no 1485 0.434821269389635 2015 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2821 7996764 71.43 µM 0.163581175164841 0.445458412153312 no 1486 0.435030432553482 2025 2987135
SGTC_456 gingerol 170 µM 0.16313967841033 0.44563139318277 no 1487 0.435204229703273 2056 442793 A herb.
SGTC_605 1315-0399 119 µM 0.162989739412143 0.445690142521734 no 1488 0.435263256702241 2063 24020461
SGTC_2477 5967686 25.23 µM 0.161430843184082 0.446301022160579 no 1489 0.435877037945055 2003 776118
SGTC_1982 st072467 71.9 µM 0.161337993975587 0.446337410717086 no 1490 0.435913600175933 1978 3163533
SGTC_2033 5192550 145 µM 0.160850037274047 0.446528653371043 no 1491 0.436105757127037 1991 182073
SGTC_2370 9071495 200 µM 0.160005217427361 0.446859789158984 no 1492 0.436438482129859 1959 21791103
SGTC_1473 k844-0725 134 µM 0.159574912939692 0.447028465665571 no 1493 0.436607971141351 2123 54682906
SGTC_1026 k007-1105 30.6 µM 0.158120430819735 0.447598683775329 no 1494 0.437180950833258 1979 7066794
SGTC_2133 5320837 200 µM 0.157723183814345 0.447754440175408 no 1495 0.437337465555722 2098 2841355
SGTC_3216 9129716 49.47 µM 0.15406584223499 0.449188821068981 no 1496 0.438778910310382 2038 8056934
SGTC_1326 1431-2094 10.8 µM 0.15267749549051 0.449733494817579 no 1497 0.439326304334523 1973 616278
SGTC_1787 fluconazole 80 µM 0.151755211396883 0.450095376110579 no 1498 0.439690004507181 2053 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3133 9127736 49.47 µM 0.150791307173661 0.450473632452608 no 1499 0.440070171862937 2174 27243420
SGTC_2677 mitomycin C 100 µM 0.150683527855058 0.450515930132705 no 1500 0.440112683862221 2067 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3193 9111931 49.47 µM 0.149879179207874 0.450831612135831 no 1501 0.440429969366767 2042 17087244
SGTC_342 k048-0088 23.3 µM 0.149607929208241 0.450938076406857 no 1502 0.440536975997423 2034 6820570
SGTC_439 amiodarone 34.4 µM 0.149019549513563 0.451169024622599 no 1503 0.440769103461532 2076 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3289 9119912 71.43 µM 0.148831923144921 0.451242674381368 no 1504 0.440843130070734 2066 17014829
SGTC_1733 st037357 54.9 µM 0.148772823815895 0.451265873234501 no 1505 0.44086644770628 2015 1272339 YGL099W LSG1
SGTC_1011 4112-3381 17.4 µM 0.148030013240158 0.451557470297542 no 1506 0.441159541015799 2071 2877139
SGTC_87 0100-0052 35.5 µM 0.147905720216211 0.451606265214275 no 1507 0.441208586891338 2104 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2151 5563267 85.4165 µM 0.146964861521388 0.451975650891285 no 1508 0.441579877776197 2022 5310824
SGTC_2228 7354201 200 µM 0.146860569163986 0.45201659914119 no 1509 0.441621037815982 2100 753451
SGTC_2207 7258803 200 µM 0.146840114827654 0.4520246301757 no 1510 0.441629110401852 2131 3666799
SGTC_2694 st077685 81.9 µM 0.146144193905937 0.452297882930115 no 1511 0.441903779613542 2048 2838096
SGTC_1002 4049-0206 172 µM 0.14582499897429 0.452423222113602 no 1512 0.442029770263635 2043 4662749
SGTC_1182 1222-0449 220 µM 0.144912810624429 0.452781439806254 no 1513 0.442389855894377 2087 658318
SGTC_282 k297-0036 65.7 µM 0.144832081799988 0.452813143988523 no 1514 0.442421725831178 2117 5061378
SGTC_1172 0370-0043 85 µM 0.144216277520422 0.453054995263323 no 1515 0.442664843854264 2093 376585
SGTC_1399 3562-5772 25 µM 0.14272056806097 0.453642493272417 no 1516 0.443255436023017 2090 23847490
SGTC_2224 6650123 117.647 µM 0.141584150238196 0.454088933430384 no 1517 0.443704243538978 2069 2908370
SGTC_2434 5670830 169.91 µM 0.141344955089463 0.454182908320462 no 1518 0.443798718524434 2049 1549830
SGTC_2920 7982904 15.77 µM 0.141087992903586 0.454283866374324 no 1519 0.443900214521024 2048 6456808
SGTC_2186 6124449 200 µM 0.14101862112482 0.454311122407859 no 1520 0.443927615906794 2121 3834182 YLR033W RSC58
SGTC_586 0957-0265 8.15 µM 0.139131558598674 0.45505262761045 no 1521 0.444673095295315 2166 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2299 7976368 114.88 µM 0.138545584932389 0.455282912980153 no 1522 0.44490462269617 2129 2979718
SGTC_1692 fluoroquinolonic acid 71 µM 0.138099873162521 0.455458086036634 no 1523 0.445080743009014 2121 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_62 0180-0423 3.232 µM 0.138065079418228 0.455471760993327 no 1524 0.445094492003464 2113 30102 YGL099W LSG1
SGTC_366 0181-0206 4.31 µM 0.137051316296314 0.455870222575452 no 1525 0.445495116609847 2178 274874
SGTC_2862 9027634 71.43 µM 0.1366861889146 0.456013747502564 no 1526 0.445639423356252 1982 5012562
SGTC_1295 1013-0063 9.78 µM 0.136295578595412 0.456167295662783 no 1527 0.44579380951942 2178 6826038
SGTC_1928 4'-methoxychalcone 40.3 µM 0.13610759263524 0.456241194914512 no 1528 0.445868112666668 2202 641818
SGTC_852 0418-0143 439 µM 0.135599693814329 0.45644086282793 no 1529 0.446068873759122 2180 5369229
SGTC_2508 celastrol 40.54 µM 0.135526910464803 0.456469476711584 no 1530 0.44609764453012 2165 122724 Celastrol is a natural product and antioxidant.
SGTC_453 enantio-paf c16 10 µM 0.135521034921122 0.456471786619567 no 1531 0.4460999671056 2157 13871343 A lipid and platelet activating factor
SGTC_1217 1183-1422 255 µM 0.133044660298634 0.457445477157607 no 1532 0.447079030307594 2135 2849664
SGTC_1502 4534-4282 27.7 µM 0.132916587372145 0.457495841398323 no 1533 0.447129674237664 2068 3278949
SGTC_1320 1313-0481 95.3 µM 0.132481927593286 0.457666774955756 no 1534 0.447301558356164 2159 6813365 YLR208W SEC13
SGTC_262 fenpropimorph 62.5 µM 0.131432589504688 0.458079468059761 no 1535 0.447716554785105 2160 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_766 1391-0721 126 µM 0.131262316590075 0.458146438793983 no 1536 0.447783900408569 2169 1020919 YIL115C NUP159
SGTC_947 3447-0010 211 µM 0.131046837126151 0.458231191603435 no 1537 0.447869128092802 2161 748350
SGTC_2483 5729050 27.16 µM 0.129634379882221 0.458786788930745 no 1538 0.448427850767701 2167 2865180
SGTC_2654 protoveratrine a 100 µM 0.128556954184237 0.459210654068168 no 1539 0.448854114581333 2155 5702278 A heart drug and vasodilator.
SGTC_2802 7925815 54.55 µM 0.127458840491217 0.459642705689662 no 1540 0.449288623977082 2094 1262923
SGTC_1351 1496-0003 46.5 µM 0.126523220360137 0.460010862024622 no 1541 0.449658884776726 2169 3891978
SGTC_1679 SEC14.276 6.7 µM 0.125329136443042 0.460480770808095 no 1542 0.450131493243988 2192 1005053 YMR079W SEC14
SGTC_3344 9148862 3.898 µM 0.124149367657726 0.460945100357566 no 1543 0.450598505369869 2156 4905352
SGTC_2813 7971799 71.43 µM 0.124071644243663 0.460975692361885 no 1544 0.450629274635079 2090 2234054
SGTC_639 0833-0042 114 µM 0.123760778025176 0.46109805188694 no 1545 0.450752343798692 2058 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3224 9130643 49.47 µM 0.123400541405702 0.461239848617857 no 1546 0.45089496418562 2124 17644395
SGTC_1838 st055369 84.5 µM 0.122645393507164 0.461537106727841 no 1547 0.451193953471719 2189 676036
SGTC_1960 st011366 51.8 µM 0.122259632714757 0.461688966773165 no 1548 0.451346700267398 2179 3972846
SGTC_2294 7971431 200 µM 0.121093125877963 0.462148212138115 no 1549 0.451808636932282 2149 5741572
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.120975252364856 0.46219462091144 no 1550 0.451855318479659 2087 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2318 6029776 164 µM 0.120355488861573 0.462438640619848 no 1551 0.452100774881972 2133 818325
SGTC_2218 6965428 192.983 µM 0.119289963840552 0.462858203167296 no 1552 0.452522817209602 2167 675684
SGTC_1520 flindersine 88 µM 0.118320165228377 0.463240108290338 no 1553 0.452906990043694 2186 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2018 5133068 143 µM 0.118003675765667 0.463364748678111 no 1554 0.453032372697385 2151 785362
SGTC_55 0767-0285 6.563 µM 0.117861650693602 0.463420682389524 no 1555 0.4530886398548 2188 3116166
SGTC_1648 st011736 69.8 µM 0.117627778601239 0.463512789773516 no 1556 0.453181296799639 2173 2855514
SGTC_2966 9084041 48.03 µM 0.116823143326933 0.463829699484694 no 1557 0.453500101801101 2012 17741380
SGTC_2859 9028643 45.46 µM 0.115641451147617 0.464295156531718 no 1558 0.453968355001635 2152 17151580
SGTC_777 1315-0167 517 µM 0.115552630395407 0.464330144143997 no 1559 0.454003553395309 2028 4221767
SGTC_2688 kanamycin b 96.69 µM 0.115537975138266 0.464335917060767 no 1560 0.454009361098825 2117 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1993 st073995 70.8 µM 0.114898615260423 0.464587777413046 no 1561 0.45426274134435 2122 3098394
SGTC_300 r073-0011 5.04 µM 0.112717274920819 0.465447169835365 no 1562 0.45512735256366 2230 2735780
SGTC_17 0960-0276 49.807 µM 0.112245828918549 0.46563292884693 no 1563 0.455314246258817 2208 6821114
SGTC_100 0086-0128 49.5915 µM 0.112067024655592 0.465703383209505 no 1564 0.455385131598526 2028 93297
SGTC_1840 st055363 71 µM 0.111994497852544 0.465731961300487 no 1565 0.455413884601458 2043 676033
SGTC_561 1550-0330 72.9 µM 0.111746936042005 0.465829510621881 no 1566 0.455512031392523 2087 6812934
SGTC_787 4152-0075 138 µM 0.111576120057584 0.465896820195041 no 1567 0.455579753601754 2067 9566539
SGTC_1273 0849-0096 14.1 µM 0.110850559334382 0.466182736270213 no 1568 0.45586742590861 2105 5286025
SGTC_2456 5770359 74.46 µM 0.110153290421406 0.466457520060265 no 1569 0.456143902805059 2199 3118787
SGTC_576 1073-0113 22.7 µM 0.109629822859514 0.466663821717673 no 1570 0.456351478992959 2238 5439563
SGTC_814 3342-0569 96 µM 0.109119196713655 0.466865071127399 no 1571 0.45655397451522 2215 4346283
SGTC_2700 st077718 96.8 µM 0.108516377907602 0.467102666666858 no 1572 0.456793044769695 2091 904970
SGTC_1819 st053448 58.6 µM 0.108350082988764 0.467168212360298 no 1573 0.456858997970675 2138 2857616
SGTC_2752 diclazuril 33.15 µM 0.108151190150871 0.467246607800607 no 1574 0.456937881191517 2201 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_500 h-89 112 µM 0.107068831822718 0.467673251476144 no 1575 0.457367186799376 2222 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_802 4112-3352 742 µM 0.106394702543574 0.467938998349297 no 1576 0.457634597990215 2186 704594
SGTC_1390 3413-2614 145 µM 0.104333093354737 0.468751788486321 no 1577 0.458452508257296 2114 3421432
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.103967181973024 0.468896062883576 no 1578 0.458597696193262 2239 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2602 kawain 100 µM 0.103236610029341 0.46918413069527 no 1579 0.458887592263496 2260 5369129
SGTC_3274 9138298 49.47 µM 0.103092385152225 0.469241001126142 no 1580 0.458944824295245 2229 17015756
SGTC_679 0422-0091 41.4 µM 0.102185130086217 0.469598762257686 no 1581 0.459304865220255 2178 627384 YHR062C RPP1
SGTC_363 0455-0021 3.06 µM 0.100951217513205 0.470085374748498 no 1582 0.459794592522694 2189 4597466
SGTC_2143 5623677 140.463 µM 0.0959829317716256 0.472045139732244 no 1583 0.461767064220558 2228 5375313
SGTC_3245 9134821 49.47 µM 0.0949180656375845 0.472465271187888 no 1584 0.462189953500668 2218 17014901
SGTC_1257 0669-0121 16 µM 0.0945984535308201 0.472591376698609 no 1585 0.462316889116107 2214 4307855
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.094237842727474 0.472733661870617 no 1586 0.462460112185084 2157 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2146 5545642 200 µM 0.0941183979108424 0.472780791637838 no 1587 0.462507552917162 2220 825326
SGTC_2403 6032726 181.2 µM 0.0939664976074934 0.472840728032545 no 1588 0.462567884991888 2167 2881040
SGTC_754 3474-0146 171 µM 0.0935252522221735 0.473014836879044 no 1589 0.46274314462009 2078 24762078
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0929449230597736 0.473243833953273 no 1590 0.462973658372961 2210 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1047 2043-3044 82 µM 0.0918567100766346 0.473673265049384 no 1591 0.463405943171645 2188 669592
SGTC_899 1083-0020 478 µM 0.0914731293327369 0.473824641173358 no 1592 0.463558328196348 2221 767123
SGTC_2182 6325192 200 µM 0.0905215304297033 0.474200195988571 no 1593 0.463936392689558 2253 736248
SGTC_2783 7738165 71.43 µM 0.0895803751591522 0.474571651708948 no 1594 0.464310340025687 2136 17201110
SGTC_213 1246-0773 967 nM 0.089266367911132 0.474695589209911 no 1595 0.464435110926419 2178 6251622
SGTC_1596 piperlongumine 63 µM 0.0891950066963042 0.474723755559746 no 1596 0.464463466820733 2250 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2741 miltefosine 3.04 µM 0.0890714846410405 0.474772510149081 no 1597 0.464512549628378 2199 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_38 0929-0051 58.268 µM 0.0885398813510838 0.47498234013843 no 1598 0.464723794026062 2237 1379719
SGTC_1096 rimcazole 32.2 µM 0.0881802981057941 0.47512427575731 no 1599 0.464866688071924 2132 18528119 A dopamine reuptake inhibitor.
SGTC_2662 daunorubicin 22.37 µM 0.088124270354685 0.475146391459351 no 1600 0.464888953233096 2216 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1178 0988-0033 191 µM 0.0866810302501562 0.475716104420661 no 1601 0.465462527661019 2194 5392207
SGTC_628 1636-0253 16 µM 0.0839060574114533 0.47681165178251 no 1602 0.466565561714454 2237 4456143
SGTC_1061 3448-9325 110 µM 0.0802005895677691 0.478274826450186 no 1603 0.468038860633405 2280 723482
SGTC_2389 9091542 195.52 µM 0.0774104920172593 0.479376744051988 no 1604 0.469148497203498 2131 3626624 YOL127W RPL25
SGTC_3270 9137563 49.47 µM 0.076816522807039 0.479611346138283 no 1605 0.469384753138804 2240 17015724
SGTC_2173 5763948 167 µM 0.0766634080633285 0.479671823549849 no 1606 0.46944565748595 2277 2867177
SGTC_489 paxilline 115 µM 0.0763772902038978 0.479784835915648 no 1607 0.469559468306755 2153 105008 A toxic potassium channel blocker.
SGTC_299 1273-0059 1.44 µM 0.0753165209159653 0.480203838364123 no 1608 0.469981438513264 2274 2848077
SGTC_328 k915-0120 63.5 µM 0.0725210343185046 0.481308155400916 no 1609 0.471093633287597 2273 6624543
SGTC_2115 tiliquinol 12.7705 µM 0.0723656537788035 0.481369540549488 no 1610 0.471155458710251 2227 71208 A bioactive hydroxyquinoline.
SGTC_3291 9121177 71.43 µM 0.0722879176398211 0.481400251410857 no 1611 0.471186389933752 2204 17015612
SGTC_2678 equilin 100 µM 0.0695167172837539 0.482495127611839 no 1612 0.472289163187668 2296 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1422 4031-0024 15.5 µM 0.0693874770548426 0.482546192543914 no 1613 0.472340598378327 2279 782427
SGTC_2892 9047358 58.44 µM 0.0680287278652364 0.483083073781089 no 1614 0.472881382860749 2221 6466771
SGTC_983 1491-0821 12.2 µM 0.0677462236617328 0.483194703274791 no 1615 0.472993826323156 2278 46495113
SGTC_2374 9071832 200 µM 0.0674161336326674 0.483325137631722 no 1616 0.47312521281343 2278 17381698
SGTC_738 1315-0003 72.4 µM 0.0661786252047202 0.48381415216773 no 1617 0.473617807038969 2279 6251474
SGTC_1490 4089-0339 670 nM 0.0652189005906315 0.484193414294397 no 1618 0.473999856335139 2299 742542
SGTC_950 1165-0508 94.1 µM 0.0634254293189147 0.484902192888479 no 1619 0.474713869172531 2225 6148369
SGTC_1910 st062352 60.4 µM 0.0614726788044139 0.485673972700348 no 1620 0.475491386200174 2281 2245730
SGTC_1220 1838-0075 193 µM 0.0610189249129592 0.48585331629889 no 1621 0.475672068618609 2233 5529645
SGTC_2815 7968870 71.43 µM 0.0608099421584994 0.48593591648726 no 1622 0.475755286139633 2280 2977326 YHR190W ERG9
SGTC_2625 euphol 100 µM 0.0606210087265501 0.486010592723899 no 1623 0.475830520874335 2305 6708538 A triterpene alcohol.
SGTC_2726 cimetidine 79.27 µM 0.0598741976307171 0.486305775762918 no 1624 0.476127915161979 2297 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_671 0560-0003 407 µM 0.0582608592475339 0.486943486019944 no 1625 0.476770422163085 2255 3238678
SGTC_2587 piperic acid 92.2 µM 0.0582575048983551 0.486944811941352 no 1626 0.476771758085722 2235 5370536
SGTC_922 1866-0035 480 µM 0.0572623018379336 0.487338206348701 no 1627 0.47716812491523 2153 3156169
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.056364817800978 0.487692983921584 no 1628 0.477525591853371 2273 688664
SGTC_1093 fluphenazine 7.97 µM 0.0553124763147077 0.488108989396814 no 1629 0.477944761360985 2296 6602611 An atypical antipsychotic.
SGTC_2863 9028737 58.44 µM 0.0553007679709507 0.488113617944333 no 1630 0.477949425175994 2319 6460917
SGTC_3062 9077494 49.47 µM 0.0551281573522432 0.488181854634238 no 1631 0.478018181962599 2259 16459633
SGTC_377 3970-0964 33.1 µM 0.0550864800709616 0.488198330611807 no 1632 0.478034783565075 2286 16481235
SGTC_2204 7233102 200 µM 0.0543206376826228 0.488501089089506 no 1633 0.478339853666817 2267 2172480
SGTC_3086 9117350 49.47 µM 0.0540941464699928 0.488590628548461 no 1634 0.4784300779307 2317 2679265
SGTC_645 0845-0943 5.41 µM 0.0528186013516133 0.48909490428271 no 1635 0.478938220226039 2261 1885106
SGTC_2882 9058044 58.44 µM 0.0526937455760921 0.489144265883819 no 1636 0.478987961205737 2238 18076804
SGTC_905 2-aminofluorene 215 µM 0.0517999591203188 0.489497628240615 no 1637 0.479344044063275 2322 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2185 6113692 200 µM 0.0515212025892193 0.489607837545225 no 1638 0.479455103531565 2267 874150
SGTC_831 k061-1017 217 µM 0.0502568656012857 0.490107716208693 no 1639 0.47995884828441 2288 1240153
SGTC_2525 harmine 47.85 µM 0.0502554080456605 0.490108292488982 no 1640 0.479959429031122 2276 5280953 A monoamine oxidase inhibitor
SGTC_2158 5657123 3.6195 µM 0.0500874742360327 0.490174689368662 no 1641 0.480026340660904 2330 2858827
SGTC_720 r052-1644 49.9 µM 0.0496908329976967 0.490331512593303 no 1642 0.480184380822301 2269 1422863 YOR257W CDC31
SGTC_3319 9138450 16.7555 µM 0.0493157848757224 0.490479799749703 no 1643 0.4803338201559 2196 2029690
SGTC_1412 3909-8563 178 µM 0.0479653800252715 0.491013735838972 no 1644 0.480871916785825 2319 23767530
SGTC_1174 0739-0097 51.1 µM 0.0479603305507702 0.491015732379697 no 1645 0.480873928918974 2261 728447
SGTC_2943 9068529 45.32 µM 0.0470121739818736 0.49139063338563 no 1646 0.481251762411658 2330 3270634
SGTC_1842 st055362 61.2 µM 0.0463985822162866 0.491633251578355 no 1647 0.481496283262573 2252 676032
SGTC_2074 5212007 75.395 µM 0.0462452237937419 0.491693890987535 no 1648 0.481557398817742 2337 758611
SGTC_736 0958-0254 92.6 µM 0.0449039872608924 0.492224236960918 no 1649 0.482091919338844 2280 6812352
SGTC_2834 9001755 58.44 µM 0.0445346413163891 0.49237028459714 no 1650 0.482239119790766 2199 2989575
SGTC_222 nsc-310342 10.666 µM 0.0439999320468294 0.492581722392677 no 1651 0.482452229017614 2328 432556
SGTC_2495 cafestol 54.53 µM 0.0421158395965525 0.493326757210613 no 1652 0.483203176601022 2269 16667697 An anti-infammatory.
SGTC_172 1112-0046 2.638 µM 0.0420923594727756 0.493336042209664 no 1653 0.483212535515935 2295 2802135 YIL048W NEO1
SGTC_399 oxolinic acid 75 µM 0.0417973399876662 0.49345270525841 no 1654 0.483330127771981 2242 4628 A DNA gyrase inhibitor.
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0413679408497793 0.493622508642639 no 1655 0.483501285202428 2320 641818 YHR062C RPP1
SGTC_1449 4112-4002 201 µM 0.040427336807626 0.493994469019632 no 1656 0.483876218219354 2184 2059539
SGTC_2621 lithochol-11-enic acid 100 µM 0.0402399335580481 0.494068577971626 no 1657 0.483950920511343 2332 6708711
SGTC_275 trichlorophene 5.69 µM 0.0399245716572359 0.494193288863104 no 1658 0.484076630683951 2260 62616
SGTC_2789 5281112 71.43 µM 0.0396790530215198 0.494290380401301 no 1659 0.484174500895185 2299 765948
SGTC_2572 astragaloside iv 100 µM 0.039218775785534 0.494472400179009 no 1660 0.484357982119862 2275 45006101 An anti-inflammatory agent.
SGTC_2436 5633522 8.09 µM 0.0387305265778753 0.494665482921052 no 1661 0.484552617486243 2347 5724242
SGTC_2050 5263056 171 µM 0.0366978295555493 0.495469344999147 no 1662 0.485362969621388 2338 763468 YGL055W OLE1
SGTC_590 k048-0076 22.4 µM 0.0360867147163503 0.495711023740749 no 1663 0.485606607774829 2341 6832814
SGTC_673 1082-0474 110 µM 0.0355195541175807 0.495935321226028 no 1664 0.485832727140787 2319 3098046
SGTC_1849 st056239 19.2 µM 0.035230606962432 0.496049592921147 no 1665 0.485947928273685 2301 5393181
SGTC_2748 diazoxide 86.69 µM 0.033226079291589 0.496842344127644 no 1666 0.486747150666661 2330 3019 A potassium channel activatior.
SGTC_879 0831-1030 162 µM 0.0328480020689549 0.496991867714059 no 1667 0.486897899365641 2348 1549252
SGTC_3335 9143315 29.6265 µM 0.031753785338747 0.497424615502328 no 1668 0.487334200994952 2290 4899691
SGTC_1361 1608-0041 5.61 µM 0.0313785285754081 0.497573025156085 no 1669 0.487483832216463 2333 X1361
SGTC_230 MPP+ 141.667 µM 0.030760477125989 0.497817457986339 no 1670 0.487730280088677 2257 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_543 3844-1095 191 µM 0.029288950337158 0.498399434440311 no 1671 0.488317069738374 2328 4230703
SGTC_2504 purpurogallin 52.29 µM 0.0291869681756336 0.4984397676669 no 1672 0.488357737348199 2312 5281571 An antioxidant.
SGTC_2420 aureobasidin a 50 nM 0.0289044770704016 0.498551490991342 no 1673 0.488470387464654 2336 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2906 7926292 26.41 µM 0.0286745409057955 0.498642429275941 no 1674 0.488562080715107 2306 2966319
SGTC_1772 st048439 82.2 µM 0.0275773817392613 0.499076349608757 no 1675 0.488999610780412 2298 2927068 YDL195W SEC31
SGTC_1503 4585-0012 61.3 µM 0.0273865693317783 0.499151814977959 no 1676 0.489075705176353 2334 2922052
SGTC_1977 st070720 65.3 µM 0.0270679239435991 0.499277837728967 no 1677 0.489202779183445 2254 682188
SGTC_2057 5236571 38.335 µM 0.0256925991511657 0.49982177287734 no 1678 0.489751263465913 2343 54684039 YBR257W POP4
SGTC_822 1487-0950 154 µM 0.0247913151863238 0.49982177287734 no 1679 0.490110709204156 2367 1958375
SGTC_1729 st035615 45.989 µM 0.0235578967473526 0.499333961047681 no 1680 0.490602628175142 2221 17385451
SGTC_2980 9014342 25.29 µM 0.0233659152403194 0.499258033236363 no 1681 0.490679196638357 2302 2996599
SGTC_919 tnp00227 403.569 nM 0.0222578479460404 0.498819798280813 no 1682 0.491121136505248 2347 1269246 A methoxyflavone. YNL221C POP1
SGTC_2165 5727197 32.143 µM 0.0221290644266656 0.498768865138921 no 1683 0.491172501044763 2315 1361712
SGTC_871 0574-0004 149 µM 0.0220423118812599 0.498734555016975 no 1684 0.491207101863265 2296 9551173
SGTC_76 0433-0009 400.328 µM 0.0220055084240086 0.498719999468704 no 1685 0.491221780757977 2242 2841569
SGTC_3320 9137005 35.139 µM 0.0210249749875302 0.498332205019602 no 1686 0.491612866459111 2285 4908713
SGTC_2846 9008642 19.48 µM 0.020411897625108 0.498089737779976 no 1687 0.491857396447987 2317 2992898
SGTC_318 1488-0629 67.2 µM 0.0203400363574651 0.498061317262434 no 1688 0.491886058995291 2328 3662576
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0203022445089073 0.498046370913071 no 1689 0.49190113264889 2354 2374 Ca(2+)-ATPase inhibitor.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0186349507803519 0.497386973687822 no 1690 0.492566160490582 2364 551469
SGTC_838 0109-0203 71.4 µM 0.0173210053332112 0.496867326950976 no 1691 0.493090264141881 2375 759422
SGTC_2476 5806916 10.51 µM 0.0170958104682589 0.496778266093813 no 1692 0.493180090593543 2353 2870194
SGTC_640 3381-0960 37.1 µM 0.0169804010910957 0.496732623649409 no 1693 0.493226125591226 2365 1745025
SGTC_3180 9109287 49.47 µM 0.0165387152543733 0.496557944818729 no 1694 0.493402307999676 2359 18891271
SGTC_1240 0356-0016 42.1 µM 0.015500761729535 0.496147455463138 no 1695 0.493816338397105 2357 4305613
SGTC_3326 9140064 16.379 µM 0.0150708032257969 0.495977416852969 no 1696 0.493987846983641 2377 1868434
SGTC_432 NS 1619 61.3 µM 0.0147460405956834 0.495848981252346 no 1697 0.494117394129877 2298 4552 A K+/calcium channel activator.
SGTC_1205 4161-2785 76 µM 0.0144885324939148 0.495747143462105 no 1698 0.494220114024522 2325 3498106
SGTC_646 4092-0839 27.3 µM 0.0135143040574831 0.495361863890802 no 1699 0.494608736828598 2367 877796
SGTC_555 4296-0685 37 µM 0.0130335777344952 0.495171751907301 no 1700 0.494800501987278 2380 2908540 YHR072W ERG7
SGTC_3330 9141424 71.43 µM 0.0118466133581591 0.494702350004432 no 1701 0.495273995595134 2370 27261020
SGTC_163 TUB2.036 7.546 µM 0.0114057623029288 0.494528011033371 no 1702 0.495449857833105 2392 15992207 YJR013W GPI14
SGTC_2720 fluspirilene 36.88 µM 0.0111864978109243 0.49444130107811 no 1703 0.495537326128614 2377 3396 An atypical antipsychotic.
SGTC_480 am 92016 50 µM 0.0110646231350288 0.494393104843711 no 1704 0.495585944080697 2364 2129 K+ channel blocker.
SGTC_1981 st071826 47 µM 0.010932719190262 0.494340942553627 no 1705 0.495638562958409 2335 11838600
SGTC_449 xestospongin c 11.1929 µM 0.0103603822131226 0.494114609231092 no 1706 0.495866879434017 2380 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.00873328935269052 0.493471178376827 no 1707 0.496515965918367 2390 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3339 9145883 14.936 µM 0.00644928687597876 0.492568002869627 no 1708 0.497427124622476 2389 2030670
SGTC_2344 7990960 76.95 µM 0.0063386165452145 0.492524240829981 no 1709 0.497471274794085 2387 140813
SGTC_824 1304-0008 100 µM 0.00567156380942558 0.492260472075423 no 1710 0.497737385530548 2388 768245
SGTC_1635 st007035 42.4 µM 0.00546180910283853 0.492177530694835 no 1711 0.497821064254837 2396 3716403
SGTC_200 k038-0079 37.545 µM 0.00494430590773085 0.491972900604896 no 1712 0.498027515362784 2378 3436683
SGTC_2629 bisabolol 100 µM 0.00484546354440286 0.49193381679169 no 1713 0.498066947288199 2388 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1336 1486-0901 104 µM 0.00371644660321538 0.491487391457785 no 1714 0.498517355730165 2374 5006114
SGTC_345 1362-0200 395 µM 0.00317345963737755 0.491272692385938 no 1715 0.498733974900494 2397 1419823
SGTC_1940 st075990 51.1 µM 0.0030165456338951 0.491210648471781 no 1716 0.498796574230984 2382 1084979
SGTC_2384 9036245 200 µM 0.00287829397127496 0.491155983837309 no 1717 0.498851728424925 2387 6462766
SGTC_1818 st052136 56.3 µM 0.00137833282304166 0.490562910884468 no 1718 0.499450124934533 2399 674169
SGTC_887 0885-0007 9.62 µM 0.000910511295126434 0.490377942103542 no 1719 0.499636758597781 2399 5719458
SGTC_3002 9075603 71.4286 µM 0.000393045959177522 0.490173347405952 no 1720 0.49984319735278 2402 20105405
SGTC_1236 0330-0013 258 µM 2.63333665948168e-05 0.490028358672638 no 1721 0.499989494506681 2403 4617066
SGTC_606 k015-0008 38.6 µM 0 0.490017947186824 no 1722 0.5 2406 1970475
SGTC_817 1391-0715 46 µM -0.00129313713316799 0.489506684988924 no 1723 0.499484113067 2414 1353946
SGTC_3022 9087993 49.47 µM -0.00169894635879787 0.489346245414216 no 1724 0.499322218791402 2409 17173644
SGTC_1711 st032263 62.8 µM -0.00184937212097527 0.489286773951701 no 1725 0.499262207689311 2415 3958979
SGTC_3145 9085516 49.47 µM -0.00324758762714194 0.48873399509775 no 1726 0.498704402263632 2416 25236195
SGTC_2444 5485484 36.41 µM -0.00344380681921705 0.488656422339779 no 1727 0.498626122569933 2414 6790631
SGTC_658 3253-0951 102 µM -0.00349848382961767 0.488634806556564 no 1728 0.498604309730131 2416 1184878
SGTC_993 3909-8757 62.7 µM -0.00383319183573516 0.488502485207405 no 1729 0.49847078145273 2414 4288324 YLR208W SEC13
SGTC_1451 4152-0210 104 µM -0.00401940138864045 0.488428870845792 no 1730 0.498396495161762 2418 659563
SGTC_2778 tioconazole 65.09 nM -0.00475662779915635 0.488137426472488 no 1731 0.498102387214529 2413 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2324 6149169 200 µM -0.00487367979230072 0.48809115341762 no 1732 0.498055690766833 2415 2888231
SGTC_3155 9099265 49.47 µM -0.00520517939864701 0.487960105692623 no 1733 0.49792344323781 2418 25236499
SGTC_1353 1498-1206 8.11 µM -0.00645678226338492 0.487465336525922 no 1734 0.49742413445779 2418 6756808
SGTC_1527 coumarin 137 µM -0.00674745578223423 0.487350433565318 no 1735 0.497308175028983 2435 323 A hepatotoxic, DNA x-linker.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.00718452240091146 0.487177663533544 no 1736 0.497133814907292 2413 442882
SGTC_930 2810-3379 265 µM -0.00740088047381404 0.487092139265118 no 1737 0.497047502819693 2416 1015764
SGTC_1279 0874-0590 65.2 µM -0.00979436768842688 0.486146057242567 no 1738 0.496092675090766 2440 3523074
SGTC_552 k242-0005 476 µM -0.0109371700451364 0.485694364951519 no 1739 0.495636787430371 2438 4088318
SGTC_575 k072-0246 11.9 µM -0.011073446087373 0.485640503099897 no 1740 0.495582424447594 2429 6796779
SGTC_2784 7567673 72.73 µM -0.0111636452378482 0.485604852859744 no 1741 0.495546442416981 2422 3471247
SGTC_1196 1588-0294 184 µM -0.0124426567510239 0.485099349888423 no 1742 0.495036226223492 2450 6144269
SGTC_396 dithiazanine 1.25 µM -0.0128440660504947 0.48494070602457 no 1743 0.494876099882238 2439 10578 An antihelmenthic.
SGTC_1254 0550-0035 264 µM -0.0138251146610099 0.484552988811278 no 1744 0.494484752922569 2430 15121435
SGTC_2674 ligustilide 100 µM -0.0140527377578887 0.484463032659002 no 1745 0.494393953266752 2440 5319022 A signalling regulator.
SGTC_1352 1496-0991 99 µM -0.0141663272208461 0.48441814264604 no 1746 0.494348642137864 2436 3000039
SGTC_287 k060-0039 29.6 µM -0.0143793366062854 0.484333962887658 no 1747 0.494263672343248 2433 5861974
SGTC_2449 5812982 45.77 µM -0.015096061069471 0.48405072374658 no 1748 0.493977771708066 2428 776185
SGTC_2348 9022543 33.42 µM -0.0169268507476172 0.483327259016399 no 1749 0.493247486017382 2446 3162678 YDL140C RPO21
SGTC_3242 9133940 49.47 µM -0.017017073448982 0.483291607526462 no 1750 0.493211497550735 2467 17248444
SGTC_2974 9094440 9.66 µM -0.0171038094796614 0.483257333919984 no 1751 0.49317689991621 2576 25236134
SGTC_855 0428-0020 25 µM -0.017470545106054 0.483112420282882 no 1752 0.493030615429869 2449 6812414
SGTC_3336 9143619 71.43 µM -0.0176819252166838 0.483028895565882 no 1753 0.492946299991199 2434 45595730
SGTC_1214 0358-0031 63.7 µM -0.0179800767680752 0.482911085256972 no 1754 0.49282737363932 2469 4301366
SGTC_3132 9126706 49.47 µM -0.018586490148964 0.482671474322235 no 1755 0.492585490137588 2489 850858
SGTC_1834 st055981 52.8 µM -0.0188138476380132 0.482581640610186 no 1756 0.492494803480417 2457 471719 YDL150W RPC53
SGTC_113 0099-0221 2.5 µM -0.0188831171175793 0.482554270961644 no 1757 0.49246717386464 2437 89219
SGTC_708 3448-5400 146 µM -0.0191546477587995 0.482446984992927 no 1758 0.492358868401549 2437 3462195
SGTC_352 k048-0007 5.11 µM -0.019281261545924 0.482396958355485 no 1759 0.492308366135473 2443 6811911
SGTC_338 4055-0136 114 µM -0.0217253540319305 0.481431323131221 no 1760 0.491333519475482 2441 2900563
SGTC_2321 7390090 138.78 µM -0.0231008315229065 0.48088793398858 no 1761 0.490784921202407 2478 649046
SGTC_1265 0819-1001 68.8 µM -0.0243235029555689 0.480404941410347 no 1762 0.490297283013917 2455 3106768
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0244299538270608 0.480362891414266 no 1763 0.490254827876337 2460 16486 A toxic proline analog.
SGTC_1708 st033234 31.827 µM -0.0244415009633089 0.480358330102277 no 1764 0.490250222610588 2502 674664
SGTC_2612 dictamnine 15.46 µM -0.0255097929392175 0.479936348104382 no 1765 0.489824168697144 2478 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_682 0kpi-0099 17 µM -0.0258777377899539 0.479791012773829 no 1766 0.489677428384897 2487 1714895 YML126C ERG13
SGTC_2691 st077356 60.2 µM -0.0262466786257255 0.47964528673453 no 1767 0.489530292266135 2484 2839272
SGTC_3030 9087619 49.47 µM -0.0263718231719039 0.479595857152149 no 1768 0.489480384091162 2454 25236973
SGTC_1060 3448-7350 82 µM -0.0267397951059151 0.479450517449043 no 1769 0.489333636282719 2456 570178
SGTC_957 1187-1561 14.1 µM -0.0271208706276676 0.479300005036878 no 1770 0.489181664264286 2440 1538454
SGTC_2130 NSC 7 2.4545 µM -0.0275350581176351 0.479136417824574 no 1771 0.489016489053103 2473 21448
SGTC_13 0199-0087 65 µM -0.0278168454538494 0.479025125295043 no 1772 0.488904115216056 2462 4589825
SGTC_3284 9108171 64.8615 µM -0.0290620938849662 0.478533331381837 no 1773 0.488407533858316 2486 8687505
SGTC_3131 9127911 49.47 µM -0.0318202843801248 0.477444139046126 no 1774 0.487307685115159 2522 45595681
SGTC_3175 9106517 49.47 µM -0.0322491566197307 0.477274794984706 no 1775 0.487136677615657 2489 41468073
SGTC_2304 7443016 91.4 µM -0.0323335022563527 0.47724149083333 no 1776 0.48710304611391 2455 939854
SGTC_1377 2944-0135 198 µM -0.0324846061367072 0.477181827367969 no 1777 0.487042796037408 2490 1894137
SGTC_2568 diosmetin 100 µM -0.0331165830319054 0.476932296438568 no 1778 0.48679080932794 2465 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2923 7992654 58.14 µM -0.0334747640891543 0.476790875575058 no 1779 0.486647994945018 2473 2985126
SGTC_3110 9122132 49.47 µM -0.0335439621817212 0.476763554382802 no 1780 0.486620404394927 2577 918317
SGTC_2606 farnesol 9.78 µM -0.0365559106060555 0.475574467041948 no 1781 0.485419549126469 2486 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1775 st081588 35.1725 µM -0.0375883125158809 0.475166934536472 no 1782 0.485007963299469 2476 1426443 YGL099W LSG1
SGTC_1184 1269-1718 139 µM -0.0393132706425164 0.474486079108863 no 1783 0.484320313176717 2505 5403821
SGTC_174 3553-0389 74.3 µM -0.0395548026999246 0.474390750283237 no 1784 0.484224030717983 2515 738071
SGTC_1120 ficusin 1.78878 µM -0.0396479903333106 0.474353971012017 no 1785 0.484186883370998 2575 6199 A DNA cross-linker.
SGTC_2711 st079103 59.1 µM -0.0401100030849631 0.474171627172089 no 1786 0.484002713456029 2527 54693780
SGTC_1607 st000305 50.6 µM -0.0410811373166315 0.473788364646605 no 1787 0.48361560607427 2467 5457690
SGTC_2427 5545055 42.75 µM -0.0411905545709148 0.473745184145456 no 1788 0.483571991822066 2483 5372858
SGTC_2284 7945075 39.21 µM -0.0419589172140122 0.473441965696408 no 1789 0.483265724284378 2522 1245402
SGTC_2163 5671233 125 µM -0.0426352421195251 0.473175080766558 no 1790 0.482996150936447 2480 701023
SGTC_2644 guaiazulene 100 µM -0.0428030874391196 0.473108849096195 no 1791 0.482929251413204 2496 3515 A coloring agent.
SGTC_2915 7971052 15.16 µM -0.0429043663361246 0.473068884858916 no 1792 0.482888884062264 2475 5741558
SGTC_1498 4478-3555 97.6 µM -0.0434043939092698 0.472871580010532 no 1793 0.482689587585437 2467 3437919
SGTC_413 propylparaben 100 µM -0.044808999703437 0.472317375272523 no 1794 0.482129775786872 2495 7175 A pharmaceutical preservative.
SGTC_872 0588-0139 234 µM -0.045013741578374 0.47223659626133 no 1795 0.482048177930755 2499 2047100
SGTC_823 0417-1665 178 µM -0.0455506184942853 0.472024781876488 no 1796 0.481834214508095 2543 3429856
SGTC_1500 4488-1866 171 µM -0.0469675668475377 0.471465790510332 no 1797 0.481269538447543 2505 2900003
SGTC_292 k038-0015 474 µM -0.0474451132661623 0.471277409291155 no 1798 0.481079237147654 2539 46368540
SGTC_2112 5488546 200 µM -0.0475769915128553 0.47122538744782 no 1799 0.481026684686044 2488 600757
SGTC_1345 1488-0192 31.4 µM -0.0488013527843017 0.470742438778091 no 1800 0.480538802047444 2498 658348
SGTC_201 4262-0159 12.803 µM -0.0488978396705645 0.470704381395513 no 1801 0.480500355248874 2497 1341029
SGTC_1474 0330-0125 5.35 µM -0.0501956696273203 0.470192503661528 no 1802 0.479983231171321 2514 X1474
SGTC_2911 7942208 15.64 µM -0.0503043826609519 0.470149628325806 no 1803 0.479939915667567 2534 1243384
SGTC_3209 9113616 49.47 µM -0.0504166764639322 0.470105341133745 no 1804 0.479895173694658 2506 16649353
SGTC_1613 st002381 52.1 µM -0.0504412925417054 0.470095632927341 no 1805 0.479885365779557 2519 551167
SGTC_951 1171-0579 82.7 µM -0.0526168105168605 0.469237712616352 no 1806 0.479018611334296 2478 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3217 9129673 49.47 µM -0.0539503881837195 0.46871188366941 no 1807 0.478487345563122 2553 17248312
SGTC_1299 1079-1439 3.74 µM -0.0556221129125549 0.468052800715045 no 1808 0.47782142410802 2517 323161
SGTC_1248 0469-0687 58.6 µM -0.0565352682270611 0.467692823100154 no 1809 0.477457700229971 2552 4017482
SGTC_1282 0886-0010 32.4 µM -0.0566421651391245 0.467650684678919 no 1810 0.477415122759283 2517 2836211 YNL267W PIK1
SGTC_502 l-744,832 89.3 µM -0.0577256146933457 0.467223612862996 no 1811 0.476983595068777 2508 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2618 avocadyne 43.43 µM -0.0577321056085869 0.467221054401183 no 1812 0.476981009879568 2528 3015189
SGTC_189 3970-0742 2.116 µM -0.0605279001275547 0.466119190200426 no 1813 0.475867597746268 2523 2891807
SGTC_1884 5633444 25 µM -0.0606773050442289 0.466060314734457 no 1814 0.475808103160687 2585 5724239
SGTC_2323 6148992 148.28 µM -0.0619775992618214 0.465547943902372 no 1815 0.475290335449601 2566 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0620783057871285 0.465508263650468 no 1816 0.475250236572557 2578 688751
SGTC_1168 k815-0004 80.5 µM -0.0621948478223688 0.46546234433997 no 1817 0.475203832695427 2514 642433
SGTC_1442 4112-3290 3 µM -0.0623454931737204 0.465402988492734 no 1818 0.47514385030138 2508 704353
SGTC_2585 alliin 100 µM -0.0625940840460493 0.465305042767407 no 1819 0.47504487021432 2570 87310 A garlic compound which reacts with lipids.
SGTC_2066 5222451 176 µM -0.0631105759679561 0.465101549762189 no 1820 0.474839226342243 2509 2281147
SGTC_836 0330-0104 1.35 µM -0.0632144854560747 0.465060611492963 no 1821 0.474797855061951 2528 46494820
SGTC_1383 3049-0032 20.7 µM -0.0633088005711841 0.465023453535809 no 1822 0.474760303990456 2572 712864
SGTC_542 3381-0244 89.3 µM -0.0649652090789954 0.46437091719382 no 1823 0.474100850423505 2536 1112843
SGTC_597 k018-0003 82.8 µM -0.0657669244668737 0.464055118522775 no 1824 0.473781694827477 2599 6786234
SGTC_1747 st037496 66.6 µM -0.0661772940861835 0.463893481153988 no 1825 0.473618336916856 2544 723305
SGTC_1384 3089-0840 101 µM -0.0664537752283021 0.463784583457878 no 1826 0.473508279169381 2502 1069836
SGTC_3292 9120825 59.784 µM -0.0666653724032081 0.463701243458484 no 1827 0.473424050889932 2524 24824900
SGTC_3338 9144300 39.5675 µM -0.0671890850482532 0.463494980021916 no 1828 0.473215587179579 2567 4901274
SGTC_3278 9139605 49.47 µM -0.0673170925624835 0.463444565945437 no 1829 0.473164634928324 2712 7958859
SGTC_3246 9135460 32.98 µM -0.0674058045204885 0.46340962825147 no 1830 0.473129324180859 2519 41446951
SGTC_2985 9022375 71.43 µM -0.0677855128771258 0.463260089773729 no 1831 0.472978188142155 2704 4939335
SGTC_2704 st078022 71.1 µM -0.0680970675668438 0.463137395760364 no 1832 0.472854182341369 2566 54697681
SGTC_3011 9081274 71.4286 µM -0.0695083994474581 0.462581640249509 no 1833 0.47229247351683 2565 6625322
SGTC_2322 7413319 38.22 µM -0.0720433726221716 0.461583600401208 no 1834 0.471283695572274 2624 1840400
SGTC_1696 st025591 34.7925 µM -0.0724380780487164 0.461428223222874 no 1835 0.471126641236965 2539 2787147
SGTC_3164 9100705 49.47 µM -0.0724508527917921 0.461423194498596 no 1836 0.471121558207725 2628 17174235
SGTC_718 1130-0073 349 µM -0.0728236683243671 0.461276439940559 no 1837 0.47097321818021 2605 6740020
SGTC_2244 6635614 200 µM -0.073218081175898 0.461121189586124 no 1838 0.470816289153575 2537 836499
SGTC_3 0833-0587 95.581 µM -0.0732290684089218 0.461116864832505 no 1839 0.470811917616916 2490 5382644
SGTC_1907 st060210 83.7 µM -0.0739990321509895 0.460813806062526 no 1840 0.470505577691263 2538 688793
SGTC_233 rapamycin 362 pM -0.075220448007564 0.460333101885571 no 1841 0.470019657642659 2560 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_479 n-linoleoylglycine 10 µM -0.0763436729594229 0.45989109317076 no 1842 0.469572840603621 2548 6433346 An anti-infammatory.
SGTC_2754 granisetron 64.02 µM -0.0765230846576126 0.459820496098098 no 1843 0.469501474459169 2590 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2642 cholecalciferol 100 µM -0.0769764199072679 0.45964211794149 no 1844 0.46932115174299 2552 9821465 A vitamin D precursor, similar to steriods.
SGTC_1461 k072-0203 53.8 µM -0.0770906979551746 0.459597153145572 no 1845 0.469275696467913 2521 5418714
SGTC_1038 k292-0204 154 µM -0.0772347469040045 0.459540475178477 no 1846 0.469218400079785 2531 4454212
SGTC_2166 5933061 31.504 µM -0.0772774128034889 0.459523687872931 no 1847 0.469201429568458 2846 2877375
SGTC_1003 4049-0218 100 µM -0.0782426155572297 0.459143938972927 no 1848 0.46881753179389 2622 295161
SGTC_2314 7727897 200 µM -0.0790491390140776 0.458826649351286 no 1849 0.468496769017764 2565 900724
SGTC_942 3253-1115 227 µM -0.0791211844695416 0.458798307648021 no 1850 0.468468116781896 2633 46497897
SGTC_514 4466-0038 2.65 nM -0.0791231697453167 0.45879752667047 no 1851 0.468467327246694 2618 5722064
SGTC_1997 st073024 93.8 µM -0.0792675746905661 0.458740720369403 no 1852 0.468409898385502 2531 686268
SGTC_1294 1000-1494 117 µM -0.0796685922256643 0.458582971725896 no 1853 0.468250419899876 2547 712797 YDL207W GLE1
SGTC_699 0375-0592 111 µM -0.0798709677198163 0.458503365562914 no 1854 0.468169940221505 2536 762578
SGTC_116 0155-0182 31.788 µM -0.0802690554630576 0.458346779142084 no 1855 0.468011634470146 2568 771486
SGTC_1762 st045503 25.4615 µM -0.0820445633819776 0.457648468358187 no 1856 0.467305638213744 2599 4645554
SGTC_1959 st077091 55.8 µM -0.0828019470409557 0.457350627513267 no 1857 0.467004510465755 2536 821356 YKL052C ASK1
SGTC_2947 9072639 7.68 µM -0.0850470167458349 0.456467896048697 no 1858 0.466112006062225 2619 16488146
SGTC_1540 guanosine 70.6 µM -0.085896224410918 0.456134054674391 no 1859 0.465774456451574 2539 6802 Guanosine is a purine nucleoside
SGTC_1790 st045711 43.5 µM -0.0859165181781769 0.456126077146019 no 1860 0.465766390228745 2568 585119
SGTC_40 0327-0103 19.753 µM -0.0871502319966193 0.455641134636971 no 1861 0.46527604894055 2595 409036
SGTC_2969 9091408 28.7 µM -0.0876755886371744 0.455434649903362 no 1862 0.465067261167888 2605 4286311
SGTC_1583 clindamycin 39.6 µM -0.0908006605601175 0.454206630870668 no 1863 0.463825492585041 2587 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1703 st026983 48.3 µM -0.0909189686757693 0.454160149386401 no 1864 0.46377848889622 2578 1104023
SGTC_2404 5161160 200 µM -0.0914643879333141 0.453945870468593 no 1865 0.463561800952274 2559 2831543
SGTC_1565 sinapyl alcohol 95.1 µM -0.0921829681121061 0.453663582276258 no 1866 0.463276334949402 2618 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1398 3558-0053 112 µM -0.0928512649181763 0.453401068490722 no 1867 0.463010861685351 2576 4532369
SGTC_2055 5235184 200 µM -0.0930487223821306 0.453323509081253 no 1868 0.462932427113057 2662 2836034
SGTC_3324 9138759 60.749 µM -0.0931192640928608 0.453295801401243 no 1869 0.462904406698716 2668 45595710
SGTC_2116 5511452 16.8835 µM -0.0937761875612496 0.453037783078859 no 1870 0.462643473942406 2672 870744
SGTC_1447 4239-0816 81.9 µM -0.094048902842273 0.452930675141488 no 1871 0.462535155004393 2584 1341554
SGTC_3126 9127922 49.47 µM -0.0941989811624031 0.452871733885966 no 1872 0.462475547045736 2793 45595682
SGTC_2760 etidronate 98.04 µM -0.0942759443992172 0.452841508005468 no 1873 0.462444979190305 2616 3305 A chelator and antioxidant.
SGTC_2395 5646831 180.19 µM -0.0945902635602873 0.452718067836816 no 1874 0.462320141856114 2674 6808628
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0976781001030313 0.451505650108688 no 1875 0.46109395298494 2646 5379071
SGTC_2772 vinpocetine 57.06 µM -0.099613176158541 0.450746085604844 no 1876 0.460325716398326 2667 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_291 SEC14.278 35.5 µM -0.0998434772226138 0.450655698780023 no 1877 0.460234295324196 2597 1068044
SGTC_1684 st024538 14.6195 µM -0.100140202949303 0.450539245877738 no 1878 0.460116509195404 2587 6732859
SGTC_750 4073-0104 132 µM -0.100215757189555 0.450509594559791 no 1879 0.460086518281529 2617 22330957
SGTC_3146 9095609 49.47 µM -0.100392493345061 0.450440235402812 no 1880 0.460016364551289 2657 17173999
SGTC_1563 conessine 56.1 µM -0.102462148783564 0.449628123417433 no 1881 0.459194927788318 2653 441082 An anti-amoebic, histamine inhibitor.
SGTC_3211 9128781 49.47 µM -0.102773817966718 0.449505845754163 no 1882 0.459071242721344 2738 17194361
SGTC_2715 st079500 56.4 µM -0.10434014080736 0.448891400668383 no 1883 0.458449711992225 2580 28246688
SGTC_828 2074-0507 139 µM -0.106169955054722 0.448173747151271 no 1884 0.457723754289234 2697 X828
SGTC_2188 6126565 140.678 µM -0.106187253054443 0.448166963677755 no 1885 0.45771689217638 2612 874518
SGTC_2840 9008771 71.43 µM -0.10644256545994 0.448066843753006 no 1886 0.457615611265803 2747 2992978
SGTC_1272 0839-0021 27 µM -0.108132236046774 0.447404328649196 no 1887 0.456945398699027 2680 5027250
SGTC_2016 5121758 140 µM -0.108630053941461 0.44720916354664 no 1888 0.456747961104541 2583 2795203
SGTC_403 arphamenine a 50 µM -0.108686703391535 0.447186955439964 no 1889 0.456725494264975 2605 5487158 An arginine aminopeptidase inhibitor.
SGTC_2100 5377183 190 µM -0.108847875333794 0.447123772613682 no 1890 0.456661575175054 2686 2844202
SGTC_1984 st072354 53.1 µM -0.109746648702797 0.446771459005917 no 1891 0.456305151757889 2610 5762938
SGTC_24 0417-1663 219 µM -0.111390546809324 0.446127169981025 no 1892 0.455653327982098 2659 4329390
SGTC_1225 1216-0074 20.6 µM -0.113756026762331 0.445200323093625 no 1893 0.454715598897919 2637 4241466
SGTC_1067 clotrimazole 1.36 µM -0.114246130922107 0.445008326826854 no 1894 0.454521342043848 2624 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1481 3346-2004 36 µM -0.114411024078125 0.444943733516424 no 1895 0.454455987715009 2618 2770522
SGTC_703 3875-0075 71.8 µM -0.114768227901264 0.444803811697072 no 1896 0.454314416536013 2633 2850814
SGTC_3247 9135149 49.47 µM -0.116556602103895 0.444103383832999 no 1897 0.453605714869289 2583 8934436 YOR116C RPO31
SGTC_1782 st039423 80.636 µM -0.117802654149066 0.443615462855181 no 1898 0.453112013243346 2658 2068169
SGTC_2222 6885208 172.143 µM -0.119885578987434 0.44280003585984 no 1899 0.452286894189343 2648 609514
SGTC_2875 9039966 71.43 µM -0.119891640571409 0.442797663212347 no 1900 0.4522844932838 2716 6463691
SGTC_3048 9093155 49.47 µM -0.120386128825075 0.442604115718642 no 1901 0.452088639539572 2616 25236002
SGTC_3207 9114163 49.47 µM -0.120440396120293 0.442582875806751 no 1902 0.45206714640553 2769 849233
SGTC_1751 st044839 27.194 µM -0.121141909134031 0.442308322464642 no 1903 0.45178931745291 2595 5291326
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.121222070044087 0.442276951400077 no 1904 0.451757571827944 2614 97141
SGTC_3026 9090633 49.47 µM -0.121924870560852 0.442001925128041 no 1905 0.451479259355579 2614 25236842
SGTC_3333 9141820 12.094 µM -0.122130354941592 0.44192151839237 no 1906 0.451397891026403 2656 1939433
SGTC_2484 5809818 12.04 µM -0.122242682899205 0.441877565092682 no 1907 0.451353411923596 2667 2870548
SGTC_1704 st028805 70.8 µM -0.122996972375365 0.441582434415621 no 1908 0.451054747728971 2655 2876101
SGTC_1349 flufenamic acid 69 µM -0.12393985686893 0.44121355783383 no 1909 0.450681447502543 2615 3371 A non-steroidal anti-inflammatory.
SGTC_2905 7799065 20.05 µM -0.124843421287507 0.440860111947577 no 1910 0.45032375553156 2694 1296806
SGTC_889 0919-1524 82.7 µM -0.124843466251359 0.440860094360306 no 1911 0.450323737732825 2689 3905452
SGTC_3340 9146634 11.102 µM -0.125236955682032 0.440706188420383 no 1912 0.45016798057076 2684 4907387
SGTC_2141 5621638 7.665 µM -0.125267881974307 0.440694092566074 no 1913 0.450155739165402 2747 2856238
SGTC_2549 cedrol 20.94 µM -0.12601412889524 0.440402238168918 no 1914 0.449860370245347 2644 6708665 A sedative which affects the nervous system.
SGTC_3281 9140613 49.47 µM -0.127101960387697 0.43997684935251 no 1915 0.449429849941523 2666 16013766
SGTC_1791 st048313 56.1 µM -0.128152253452514 0.439566205401906 no 1916 0.449014242320719 2662 1204976
SGTC_2993 9054257 71.4286 µM -0.129392922377489 0.43908121202477 no 1917 0.44852337386409 2629 6470217 YGL055W OLE1
SGTC_3171 9103192 49.47 µM -0.129502459601055 0.439038396903134 no 1918 0.448480039430731 2642 13018434
SGTC_1089 terbinafine 2.25 µM -0.13177590203508 0.438149931840642 no 1919 0.447580773849038 2752 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2155 5570423 76 µM -0.132492707634379 0.437869867439535 no 1920 0.447297295320943 2652 797402
SGTC_2307 7538926 6.34 µM -0.133583835642641 0.437443610643033 no 1921 0.446865833452311 2709 96582
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.133706577497481 0.437395665211328 no 1922 0.44681730189006 2653 688662
SGTC_659 k018-0002 107 µM -0.1337437618388 0.43738114044279 no 1923 0.446802599530479 2700 6797879 YHR007C ERG11
SGTC_154 3389-1638 511.116 µM -0.134159505474024 0.437218750414692 no 1924 0.446638223158677 2740 5238686
SGTC_2205 7238770 200 µM -0.134455706830589 0.437103060213069 no 1925 0.446521116904459 2732 279867
SGTC_503 tyrphostin 8 294 µM -0.139146802950588 0.435271537354444 no 1926 0.444667072263965 2656 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2555 cholic acid 100 µM -0.139429380692492 0.435161255763486 no 1927 0.44455542833708 2813 6708657 Influences liver metabolism.
SGTC_2063 5246145 200 µM -0.139438790353604 0.435157583542574 no 1928 0.444551710740147 2748 711240
SGTC_133 0724-0033 378.92 µM -0.142019770857767 0.434150540504609 no 1929 0.44353219454465 2626 280309
SGTC_1656 st012921 11 µM -0.14205332607226 0.434137450781204 no 1930 0.443518942305215 2761 6732821
SGTC_2463 5473429 200 µM -0.142444107056556 0.433985014371224 no 1931 0.443364612582153 2723 5399405
SGTC_1991 st073000 8.92 µM -0.142759459384015 0.43386200843685 no 1932 0.44324007788836 2851 4301969 YIL048W NEO1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.142822692097497 0.433837344734205 no 1933 0.443215107551205 2691 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1226 3909-7979 35.4 µM -0.145729133988701 0.432703976616257 no 1934 0.44206761064382 2792 6615510
SGTC_3240 9133527 49.47 µM -0.147876757895177 0.43186686486446 no 1935 0.441220015517422 2678 17617455
SGTC_1107 amlodipine 47 µM -0.148617490569006 0.431578209066005 no 1936 0.440927735403803 2713 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.149160663392048 0.431366563489068 no 1937 0.44071342937815 2811 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2223 6903751 107.57 µM -0.150461255943653 0.430859871889588 no 1938 0.440200357994654 2773 5598863
SGTC_2278 7948257 134.34 µM -0.151081224099122 0.430618381472842 no 1939 0.439955821739121 2680 1247028
SGTC_460 trequinsin 123 µM -0.151374651391727 0.430504094514271 no 1940 0.439840092143011 2681 5537 A vasodilator.
SGTC_1802 st050112 57.9 µM -0.151869908677411 0.430311210025828 no 1941 0.439644771174942 2651 4662563
SGTC_2295 7971645 200 µM -0.152479577024259 0.430073789476538 no 1942 0.439404348627142 2762 2978226 YKL099C UTP11
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.152498995524116 0.430066227827781 no 1943 0.439396691313766 2793 23847180
SGTC_339 3091-4833 71.4 µM -0.153132739946543 0.429819459072716 no 1944 0.439146798805191 2682 3240077
SGTC_481 bay k-8644 50 µM -0.153985019374908 0.429487639932187 no 1945 0.438810773754401 2680 2303 A calcium channel antagonist.
SGTC_2782 7736369 71.43 µM -0.154735305368978 0.42919557125595 no 1946 0.438514997765575 2723 2950836 YOL077C BRX1
SGTC_10 0279-0212 42.575 µM -0.155655462406343 0.428837428711839 no 1947 0.43815230250576 2704 39851 YBR002C RER2
SGTC_3237 9133362 49.47 µM -0.155865774343199 0.42875557953811 no 1948 0.438069411826518 2745 43845137
SGTC_402 epigallocatechin gallate 10 µM -0.157512252778224 0.428114909418486 no 1949 0.437420576054207 2694 65064 An antioxidant.
SGTC_648 0375-0473 33.3 µM -0.157837845757635 0.42798823855719 no 1950 0.437292287914715 2704 1713139
SGTC_3265 9137266 49.47 µM -0.157888587422712 0.427968498349871 no 1951 0.437272295589941 2642 17224265
SGTC_2104 5389443 200 µM -0.160129913496543 0.427096727977558 no 1952 0.43638936882448 2842 2244536
SGTC_1678 st019265 80.2 µM -0.162410698558362 0.426209975293078 no 1953 0.43549122322926 2882 5367020
SGTC_620 0109-0052 432 µM -0.163001922762981 0.425980172298478 no 1954 0.435258460386925 2755 493037
SGTC_2037 5169046 200 µM -0.165020029646803 0.425195943920734 no 1955 0.434464108404167 2808 5718022
SGTC_2038 4100038 30.985 µM -0.166297100328941 0.424699831958585 no 1956 0.43396157393885 2798 3596803
SGTC_1934 st074720 32.6 µM -0.167239739828693 0.424333715109506 no 1957 0.433590708426476 2707 17250992
SGTC_521 r062-0005 13.8 µM -0.167245041454343 0.42433165616679 no 1958 0.433588622756868 2672 2832033
SGTC_1305 1181-0477 144 µM -0.167858901580009 0.424093271033256 no 1959 0.43334714153501 2841 6252086
SGTC_109 0132-0036 33.701 µM -0.168022956163779 0.424029567124592 no 1960 0.433282609705154 2671 67274 A color developer.
SGTC_2967 9089538 49.85 µM -0.168916469597142 0.42368264250307 no 1961 0.432931172241924 2932 728216
SGTC_1029 k015-0030 64.7 µM -0.169914330606401 0.423295272750848 no 1962 0.432538755404761 2816 2208316
SGTC_1284 0929-0043 16 µM -0.170336250587535 0.423131505646051 no 1963 0.432372851981705 2773 1239883
SGTC_1125 tnp00248 1.32998 µM -0.171568348875847 0.422653346131961 no 1964 0.431888446183544 2881 24207736
SGTC_2636 apigenin dimethyl ether 100 µM -0.171585790246259 0.422646578204784 no 1965 0.431881589752054 2841 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_232 clozapine 119 µM -0.172131061143933 0.422435003505314 no 1966 0.431667246968324 2699 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1330 1469-0054 61.8 µM -0.173289447597795 0.421985603524777 no 1967 0.431211958905242 2874 7102664
SGTC_1050 3232-1156 69.3 µM -0.173579121048391 0.421873239572259 no 1968 0.431098120949763 2756 700529
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.174539115754532 0.421500904394619 no 1969 0.430720896294992 2700 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.174595603148336 0.42147899786941 no 1970 0.430698701848936 2852 5282362
SGTC_3004 9076122 71.4286 µM -0.175406284823589 0.421164632074909 no 1971 0.430380201285774 2855 44782551
SGTC_393 acivicin 6.25 µM -0.176707007488675 0.420660343473066 no 1972 0.429869268159968 2726 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1251 0490-5699 265 µM -0.177155609913224 0.420486451004483 no 1973 0.429693081122888 2809 3883818
SGTC_2262 9014885 67.46 µM -0.177923029383237 0.420189010973615 no 1974 0.42939171228582 2739 6457424
SGTC_2777 climbazole 1.536 µM -0.178756096744316 0.419866178419116 no 1975 0.429064609829645 2752 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2008 4012253 172 µM -0.178872631794926 0.419821022729559 no 1976 0.429018856422174 2717 603940
SGTC_250 brefeldin a 552.239 µM -0.179238603179768 0.419679220841884 no 1977 0.428875176774676 2718 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2582 agaric acid 100 µM -0.179355000495548 0.419634122891273 no 1978 0.428829481391445 2814 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1700 st030840 7.9285 µM -0.179934336337295 0.41940967587393 no 1979 0.428602059306314 2843 5499307
SGTC_733 4069-0007 56.1 µM -0.180222143049339 0.419298183180583 no 1980 0.428489087702513 2735 5717425 YNL287W SEC21
SGTC_1406 3909-7906 11.9 µM -0.18030264688375 0.419266998168925 no 1981 0.428457488906572 2759 X1406
SGTC_1491 4138-0063 26.5 µM -0.180516522820757 0.419184150869996 no 1982 0.428373542064243 2705 23883227
SGTC_2319 6033012 152.6 µM -0.181772324810534 0.418697773956914 no 1983 0.427880702134476 2746 847246
SGTC_3055 9094636 49.47 µM -0.183130349493539 0.418171945660646 no 1984 0.42734787149119 2890 25236176
SGTC_431 k089-0097 107 µM -0.183481089133978 0.418036162699439 no 1985 0.427210277789539 2797 5499420
SGTC_2788 5282734 71.43 µM -0.184937440063952 0.417472465567493 no 1986 0.426639052275257 2879 743706
SGTC_2835 9006588 71.43 µM -0.187319434200385 0.416550853701559 no 1987 0.425705093191886 2968 2345538
SGTC_185 k048-0037 25.491 µM -0.187878723937028 0.416334526480761 no 1988 0.425485860782258 2791 6827589
SGTC_179 1273-0063 6.77 µM -0.18799034279356 0.416291356545567 no 1989 0.425442110775254 2746 3108139
SGTC_891 0929-0073 133 µM -0.188773855152493 0.415988352168276 no 1990 0.425135031982004 2887 5603632
SGTC_2073 5212005 126 µM -0.189172926206639 0.415834040310917 no 1991 0.424978643141889 2708 691789
SGTC_1995 st072814 61.1 µM -0.189903292281481 0.415551657696503 no 1992 0.424692456274833 2752 5769371
SGTC_2827 7993847 71.43 µM -0.190739276069254 0.415228493463653 no 1993 0.424364932855018 2864 2985692
SGTC_2375 9072683 200 µM -0.192076073822237 0.414711850031054 no 1994 0.423841308136115 2764 16798029
SGTC_2369 9071472 200 µM -0.192331137370148 0.414613290212336 no 1995 0.423741414790519 2889 17296037
SGTC_2889 9059656 51.95 µM -0.193177902249989 0.414286128004751 no 1996 0.42340982210993 2841 3949838
SGTC_509 pifithrin 175 µM -0.193799329384828 0.414046066738925 no 1997 0.423166506065575 2749 4817 A p53 inhibitor.
SGTC_2519 cryptotanshinone 88.04 µM -0.195068025309741 0.413556061208137 no 1998 0.422669846905634 2862 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2007 4011539 71.82 µM -0.195398933125768 0.413428277537376 no 1999 0.422540325878213 2737 45595301
SGTC_2336 9001819 198.65 µM -0.196416702733455 0.413035312202103 no 2000 0.422142011996635 2974 2989602
SGTC_157 1348-1695 65.819 µM -0.196417348087285 0.413035063055739 no 2001 0.422141759456451 2753 5380510
SGTC_3114 9122766 49.47 µM -0.19697651026477 0.412819205157242 no 2002 0.421922959873362 2803 17176985
SGTC_3152 9099253 49.47 µM -0.19815371417842 0.41236484584496 no 2003 0.421462400046048 2857 25236131
SGTC_1749 st037932 54.2 µM -0.198363257216916 0.412283981894503 no 2004 0.421380431351213 2889 594497
SGTC_1440 4100-1550 40 µM -0.198621234105084 0.412184432137294 no 2005 0.421279521063818 2766 742806
SGTC_2472 5377652 49.4 µM -0.199483923927012 0.411851572993225 no 2006 0.420942108744991 2803 1610903
SGTC_715 0868-0130 184 µM -0.200620852755205 0.41141299871434 no 2007 0.42049752571497 2902 2876258
SGTC_1111 tnp00062 510.699 nM -0.201151549703884 0.411208318360846 no 2008 0.420290037412838 2906 676306
SGTC_1666 st014829 29 µM -0.201969055105616 0.410893068405955 no 2009 0.419970458039537 2730 3858230
SGTC_578 3460-0051 92 µM -0.202981558696632 0.41050270220063 no 2010 0.419574723098419 2763 2876744
SGTC_1760 st045453 10.4495 µM -0.203789118750256 0.410191414581408 no 2011 0.419259148195223 2852 3323419 YIL048W NEO1
SGTC_2540 epiandrosterone 100 µM -0.206382375316401 0.409192183683618 no 2012 0.418246118474755 2801 441302 A steroid.
SGTC_1275 0867-0008 21.1 µM -0.206464611767897 0.409160506034128 no 2013 0.418214002460576 2772 3422836
SGTC_1926 methyl fluorone black 53.6 µM -0.208858333804201 0.408238700163806 no 2014 0.417279415792235 2771 72721 Reacts with homocysteine.
SGTC_3257 9139206 32.98 µM -0.209950037020593 0.407818460994852 no 2015 0.41685333426673 2881 4910041
SGTC_1832 st054113 55 µM -0.210127753880045 0.407750060863646 no 2016 0.416783982272433 2815 1251267
SGTC_3162 9099653 49.47 µM -0.210446369095274 0.40762743844439 no 2017 0.416659652773416 2807 25237511
SGTC_372 0155-0182 15.9 µM -0.21255407294826 0.406816494914582 no 2018 0.415837398624535 2780 771486
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.213632574777171 0.406401693293938 no 2019 0.415416797389423 2871 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2707 st078556 66.6 µM -0.218899815092242 0.404377381847881 no 2020 0.413364045255087 2877 17250899
SGTC_1857 st056007 79.3 µM -0.219044498784388 0.4043218126986 no 2021 0.413307692169903 2866 619834
SGTC_2347 9049783 174.81 µM -0.220854143251615 0.403626939901327 no 2022 0.412603002047808 2961 6467988 YPL169C MEX67
SGTC_1232 0279-0259 161 µM -0.221117234908292 0.403525942432061 no 2023 0.412500575431614 2818 1560000
SGTC_1948 st076329 66.6 µM -0.222716645568984 0.402912088128213 no 2024 0.411878022718421 2752 24208413
SGTC_1828 st055811 49 µM -0.222934950305756 0.402828321224064 no 2025 0.411793067204099 2945 5877589
SGTC_2965 9082772 38.63 µM -0.223072155909084 0.402775675594127 no 2026 0.41173967436014 2948 16459634
SGTC_169 k015-0017 16.025 µM -0.22308016046865 0.40277260430837 no 2027 0.41173655947803 2983 1840002
SGTC_178 4092-0806 87.505 µM -0.223278797373824 0.402696390832067 no 2028 0.411659263997571 2852 2169044
SGTC_102 gallobenzophenone 83.616 µM -0.223922687873525 0.402449366839404 no 2029 0.411408730788105 2981 70837
SGTC_2996 9066192 71.4286 µM -0.224957416554963 0.402052482190637 no 2030 0.41100620092679 2843 6472854
SGTC_285 1486-1325 46 µM -0.225758216764615 0.401745393365503 no 2031 0.41069473814251 2911 22310230
SGTC_164 4100-3994 89.624 µM -0.226790291431598 0.401349705490348 no 2032 0.410293406669914 2856 4615967
SGTC_1021 4476-0760 85.3 µM -0.22923936509181 0.400411158789776 no 2033 0.409341439086582 2834 746768
SGTC_2963 9082507 9 µM -0.229770877026 0.400207545750439 no 2034 0.40913490802783 2977 16459611
SGTC_444 curcumin 90.4 µM -0.230640929629145 0.399874302189241 no 2035 0.408796883746497 2952 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1900 st060200 72.8 µM -0.23124204461089 0.399644108455183 no 2036 0.408563384067836 2789 688945
SGTC_1526 st051518 75 µM -0.232496845215624 0.399163701824078 no 2037 0.408076068623408 2872 673993
SGTC_1902 st060212 70.5 µM -0.233199111573851 0.398894902256055 no 2038 0.407803397847995 2820 688944
SGTC_3049 9092223 49.47 µM -0.234543286222602 0.398380539587935 no 2039 0.40728161631223 2928 8623917
SGTC_1416 3966-0321 25.3 µM -0.235945072434077 0.397844319260678 no 2040 0.406737646341094 2879 582530 YLR208W SEC13
SGTC_1901 st060216 58.6 µM -0.237108681654462 0.397399354426201 no 2041 0.406286238704255 2822 688792
SGTC_333 3486-0131 40.1 µM -0.237259319170086 0.397341760300386 no 2042 0.406227809856695 2986 6744690
SGTC_1949 st076024 69.1 µM -0.23840468359843 0.396903919686517 no 2043 0.405783617578288 2761 2921930
SGTC_397 arbidol 50 µM -0.23880446225912 0.396751126107361 no 2044 0.40562860497346 2974 131410 A RNA synthesis inhibitor.
SGTC_451 chloral hydrate 100 µM -0.240693293374238 0.396029438212023 no 2045 0.404896418648695 2951 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2051 5263410 176 µM -0.2408284793556 0.395977799746498 no 2046 0.404844027899485 2848 227584
SGTC_253 dyclonine 31.25 µM -0.241286942700383 0.395802689093919 no 2047 0.404666365096035 2840 3180 An oral anasthetic.
SGTC_641 4092-0595 30 µM -0.242524273231987 0.395330194191272 no 2048 0.404186975420253 2899 786260
SGTC_1489 4065-0444 182 µM -0.243007683203909 0.395145637938816 no 2049 0.403999722747817 2948 2877968
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.243130114247322 0.395098899947762 no 2050 0.403952301604915 2928 6708739 YPR165W RHO1
SGTC_629 3448-6466 76.7 µM -0.243628943673175 0.394908487666331 no 2051 0.403759104900288 2875 573744
SGTC_851 0394-0702 453 µM -0.243783160953103 0.394849625197345 no 2052 0.40369938127578 2967 762646
SGTC_2381 9035592 200 µM -0.24480881917838 0.394458207650416 no 2053 0.403302232477716 2889 4749657
SGTC_862 0452-0056 10.2 µM -0.244988589455566 0.394389613653177 no 2054 0.403232633242724 2839 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2596 sinensetin 100 µM -0.245377154938146 0.394241361961599 no 2055 0.403082208058107 2893 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1807 st050092 58.9 µM -0.24775525309496 0.39333436663991 no 2056 0.402161889239069 2856 5008496
SGTC_1663 st014140 55.4 µM -0.247756376474398 0.393333938324677 no 2057 0.402161454621379 2865 4207120
SGTC_225 nsc-122657 1.016 µM -0.24909547480167 0.392823467048386 no 2058 0.401643464872226 2968 275685
SGTC_2851 9015922 71.43 µM -0.249943955258423 0.392500117182687 no 2059 0.401315345183564 3047 2996893
SGTC_1283 0922-0125 16.4 µM -0.251312703696034 0.391978653359988 no 2060 0.400786177075518 2969 3360884
SGTC_1316 1272-0050 65.9 µM -0.251704638089068 0.391829370437908 no 2061 0.400634685863603 2852 7340392
SGTC_2740 felodipine 17.08 µM -0.251739347171222 0.391816150948663 no 2062 0.400621270764488 2957 3333 L-type calcium channel blocker
SGTC_683 panaxydol 45 µM -0.2523508766514 0.391583261014217 no 2063 0.400384933175061 2891 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1229 0139-0193 12.2 µM -0.25248244695759 0.391533159920299 no 2064 0.400334090008098 2979 3090752
SGTC_1439 4092-1168 46 µM -0.252808815586934 0.391408888694406 no 2065 0.400207977546336 2905 2886240
SGTC_1969 st069479 40.1 µM -0.252851356194034 0.391392691344101 no 2066 0.400191540149701 3031 3895485
SGTC_1341 1486-1360 280 µM -0.252977053653557 0.391344833094981 no 2067 0.400142972553029 2836 3976547
SGTC_302 1094-0063 18.9 µM -0.253262043253223 0.391236331798432 no 2068 0.400032862604582 2837 5440289
SGTC_737 1950-0117 57.9 µM -0.253549147713584 0.391127033889519 no 2069 0.39992194358424 2989 5393513
SGTC_2216 7189485 200 µM -0.253865586134847 0.391006578784056 no 2070 0.399799701129081 2967 731273
SGTC_702 1488-0190 94 µM -0.255273521076831 0.390470762698766 no 2071 0.399255924860966 2943 949357
SGTC_499 genistein 192 µM -0.258011205765043 0.389429481508441 no 2072 0.39819912950202 2911 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1758 st042942 75.2445 µM -0.259127735019806 0.389005035793591 no 2073 0.397768343002789 2856 669317
SGTC_2259 7964009 200 µM -0.2594659598218 0.388876486619453 no 2074 0.397637871503864 3017 313134
SGTC_1049 3226-0134 66 µM -0.261539564016163 0.38808863783783 no 2075 0.396838221621994 2864 5702385
SGTC_2079 5212404 121 µM -0.261819169811414 0.387982439077932 no 2076 0.396730429545344 2986 758462
SGTC_2092 5303694 80.6725 µM -0.262424698763139 0.38775247820741 no 2077 0.396497016438417 2876 1963699
SGTC_1493 4348-0038 111 µM -0.263875794629193 0.387201557932032 no 2078 0.395937813928887 2915 800424
SGTC_1568 digitonin 820 nM -0.264257594567486 0.387056642195094 no 2079 0.39579071687474 3034 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_531 3788-1495 174 µM -0.266509738160556 0.386202140954338 no 2080 0.394923330281653 2837 2896655
SGTC_884 0851-0618 334 µM -0.268051469419153 0.385617499956034 no 2081 0.394329850485195 3023 9642473
SGTC_1965 Pectolinarigenin 58.4 µM -0.268053411072041 0.385616763823985 no 2082 0.394329103212401 2881 5320438 An anti-inflammatory.
SGTC_2595 hexamethylquercetagetin 100 µM -0.268317627520552 0.38551659621224 no 2083 0.394227419374032 2960 386331
SGTC_1919 st067113 52.3 µM -0.268520734435507 0.385439601144974 no 2084 0.394149258471735 3013 1268243
SGTC_544 k015-0020 52.4 µM -0.269159125089413 0.385197625346074 no 2085 0.393903616665336 2919 3008304
SGTC_1951 sophoraflavanone G 9.2 µM -0.270830837013387 0.384564191091209 no 2086 0.393260570705762 2869 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2931 9014674 55.67 µM -0.271165210196124 0.384437529489481 no 2087 0.393131984546349 2889 2996810
SGTC_1777 st045864 34.765 µM -0.27213254507689 0.384071169544156 no 2088 0.392760053075637 2920 4691462
SGTC_1379 2144-0755 36.5 µM -0.272577516941885 0.383902679551576 no 2089 0.392588998291009 3050 5392327
SGTC_788 1182-0090 188 µM -0.274327385153421 0.383240299565674 no 2090 0.391916520569105 3091 5715185
SGTC_652 0437-0092 114 µM -0.274759692951574 0.38307670999246 no 2091 0.391750433491876 2901 3091274
SGTC_2396 5342950 42.78 µM -0.275425395642201 0.382824842252432 no 2092 0.391494717695811 2989 1886677
SGTC_1378 2093-0007 380 nM -0.277839444120787 0.381911906467661 no 2093 0.390567805373953 3018 3618014
SGTC_1340 1486-1359 257 µM -0.278164346259336 0.381789086196255 no 2094 0.39044310137002 2902 4309068
SGTC_411 enrofloxacin 100 µM -0.27932535613292 0.381350295817827 no 2095 0.389997574501955 3061 71188 A bacterial gyrase inhibitor.
SGTC_860 0443-0016 25.1 µM -0.280092587686538 0.381060413076994 no 2096 0.389703235685502 2890 5337942
SGTC_2361 9034121 116 µM -0.280353498386658 0.380961848506475 no 2097 0.389603154952439 2928 6496917
SGTC_1844 rapamycin 4 nM -0.280383246907421 0.380950610859944 no 2098 0.38959174441046 2870 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2004 4023728 41.89 µM -0.280852784722348 0.380773254002053 no 2099 0.389411657951826 3059 360084 YDR527W RBA50
SGTC_1569 carminic acid 40.6 µM -0.281055489030725 0.380696694960159 no 2100 0.38933392011029 3063 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_749 1000-0129 128 µM -0.283564097601131 0.379749610423577 no 2101 0.388372227045992 3062 708470
SGTC_83 0170-0301 39.027 µM -0.284449101787006 0.379415663149346 no 2102 0.388033117249887 2884 3089716
SGTC_2220 6782180 200 µM -0.285305919442796 0.379092437461272 no 2103 0.387704889093192 2965 833803
SGTC_3018 9082602 49.47 µM -0.285762484573314 0.378920237442691 no 2104 0.387530021700251 2913 17332089
SGTC_2382 9035899 200 µM -0.285978833813824 0.37883864664528 no 2105 0.387447166508671 2928 6462679
SGTC_277 nystatin 15.5 µM -0.286105233709415 0.37879098053041 no 2106 0.387398761557794 2865 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3195 9113082 49.47 µM -0.286173960107604 0.378765064190961 no 2107 0.387372443457918 2987 17018038
SGTC_845 0330-0138 4.51 µM -0.287334207706567 0.378327623696878 no 2108 0.386928216245284 2987 9039800
SGTC_1031 k035-0009 16 µM -0.287398830206892 0.378303264080328 no 2109 0.38690347839772 3099 5180959
SGTC_2086 5274770 176.623 µM -0.287477598489191 0.378273572829229 no 2110 0.38687332608854 2990 689278
SGTC_2301 7769476 200 µM -0.287947992921873 0.378096275321411 no 2111 0.386693274449526 2970 977820
SGTC_130 0136-0219 337.655 µM -0.288382700172024 0.37793245157699 no 2112 0.386526904379849 2871 234244
SGTC_1788 fluconazole 20 µM -0.288391138173538 0.377929271849391 no 2113 0.386523675215294 3012 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1020 4335-0961 93.3 µM -0.289188014116045 0.377629019034885 no 2114 0.38621875177063 2874 669075
SGTC_2529 gangaleoidin 93.61 µM -0.29027055283829 0.377221250548149 no 2115 0.385804632459444 2889 4565183
SGTC_467 ro 31-8220 72.8 µM -0.290415762930146 0.377166563506528 no 2116 0.385749093014144 2962 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_781 4335-2806 94.4 µM -0.291048719703649 0.376928216756666 no 2117 0.38550702930197 3076 845254
SGTC_124 0136-0217 7.121 µM -0.293139740017139 0.376141154131455 no 2118 0.384707671070786 3069 3976905
SGTC_2539 epi(13)torulosol 80 µM -0.293903848038792 0.375853671200466 no 2119 0.384415688797778 3036 6708597
SGTC_1642 st009582 77.7 µM -0.295626379874764 0.375205850183823 no 2120 0.383757712701485 3070 6739311
SGTC_3101 9120531 49.47 µM -0.29648345428159 0.37488364701031 no 2121 0.383430450424673 3139 24824904
SGTC_2265 7929201 200 µM -0.298022661033838 0.374305226605928 no 2122 0.382842934028848 2879 1265108
SGTC_235 0330-0087 5 mM -0.298033494143496 0.374301156619008 no 2123 0.382838799975968 2962 46494818 YHR062C RPP1
SGTC_2046 4110841 106 µM -0.299436483684037 0.373774173588876 no 2124 0.382303514223908 3087 44119630 YMR134W ERG29
SGTC_195 4234-0266 16.654 µM -0.301051663172839 0.373167781099061 no 2125 0.381687549630198 2972 2303354
SGTC_2812 7970281 58.44 µM -0.30334491732025 0.372307356409729 no 2126 0.380813509336445 3085 2233435
SGTC_383 2324-0395 7.37 µM -0.306957607013696 0.370953175626577 no 2127 0.379437820070866 3077 3146421
SGTC_1432 4049-0298 68.4 µM -0.307222385543451 0.370853988626059 no 2128 0.379337053861889 3053 741646
SGTC_3137 9097352 49.47 µM -0.307309192190158 0.370821472407838 no 2129 0.379304019822459 3242 44120435
SGTC_1556 plumbagin 1.48 µM -0.307737823540411 0.370660928293436 no 2130 0.379140918220423 2951 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_523 1934-0222 13.7 µM -0.307993504453713 0.370565173583471 no 2131 0.3790436374765 2955 1361595
SGTC_3199 9111318 49.47 µM -0.309492072313952 0.370004108369141 no 2132 0.378473620867711 3069 8548020
SGTC_2820 7989630 71.43 µM -0.311857317456297 0.369119121471333 no 2133 0.377574480802917 3026 2984098
SGTC_265 mycophenolic acid 32.932 µM -0.312176767250529 0.368999648260674 no 2134 0.377453093744695 3205 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1652 st011932 78 µM -0.312960188294102 0.368706704870699 no 2135 0.377155454489609 3062 1551076
SGTC_623 k072-0108 16.9 µM -0.313219298188172 0.368609833095481 no 2136 0.377057028868848 3021 5382803
SGTC_2474 5321570 43.32 µM -0.315085265898823 0.367912462466879 no 2137 0.376348457642625 3081 2841384
SGTC_257 daunorubicin 18.5 µM -0.315094120194485 0.367909154374565 no 2138 0.376345096357305 3059 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2930 9013230 14.89 µM -0.316898041058131 0.367235388218661 no 2139 0.375660484246853 3098 2995857
SGTC_1686 st019653 115.5 µM -0.318344124599273 0.366695569587763 no 2140 0.375111958627127 3103 97252
SGTC_2187 6125751 200 µM -0.320795339546356 0.365781140902467 no 2141 0.374182745700307 3003 874498
SGTC_1655 st012546 55.1 µM -0.321124529890942 0.365658393979952 no 2142 0.374058010890601 3073 720985 YLR208W SEC13
SGTC_3065 9113888 49.47 µM -0.321420592549734 0.365548011297857 no 2143 0.373945839884028 3164 16648368
SGTC_1194 1488-0194 225 µM -0.321532042213635 0.365506461785873 no 2144 0.37390361705702 2938 1391452
SGTC_1309 pyrazolanthrone 13.4 µM -0.32202934119261 0.36532108315746 no 2145 0.373715233239655 3064 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_584 0986-0246 15.4 µM -0.32206686760887 0.365307095674555 no 2146 0.373701018931206 3019 53315 YDR232W HEM1
SGTC_2462 5162487 171.77 µM -0.322502382033484 0.365144776454893 no 2147 0.373536066738998 2942 2259986
SGTC_340 k038-0059 454 µM -0.322702349766011 0.365070255197531 no 2148 0.373460336212287 2986 23733424
SGTC_1177 0983-0204 23.6 µM -0.322742069144014 0.365055453725961 no 2149 0.373445294519959 3127 766818
SGTC_2197 6588183 93.1375 µM -0.323452908001851 0.364790592830713 no 2150 0.373176133115318 2988 884136
SGTC_2886 9058944 51.95 µM -0.32375682680755 0.364677371365492 no 2151 0.373061072165375 3011 4949929
SGTC_1005 4092-0690 4.4 µM -0.324163742901461 0.364525797922567 no 2152 0.372907035088208 3025 1529343
SGTC_3311 9131146 2.8755 µM -0.32421828680853 0.364505482301954 no 2153 0.372886389171304 3003 4900406 YPR165W RHO1
SGTC_1831 st055328 12 µM -0.324683245656208 0.36433231750516 no 2154 0.372710408140284 3119 1103068
SGTC_1426 4048-4480 71.7 µM -0.324697452658928 0.364327026821603 no 2155 0.37270503138789 3087 14224343
SGTC_1891 st059073 26.2 µM -0.325077724513769 0.364185423305955 no 2156 0.372561123720792 3156 688754
SGTC_2492 derrusnin 100 µM -0.325639464676981 0.363976279556271 no 2157 0.372348574891378 2906 1715307 Part of coumarin class of compounds.
SGTC_1185 1319-0113 81.3 µM -0.325641933527175 0.363975360458051 no 2158 0.372347640824213 3078 4672763
SGTC_2564 betulinic acid 100 µM -0.32607107930999 0.363815610886363 no 2159 0.372185288809229 3263 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_513 4245-1575 41.7 µM -0.327352969689823 0.363338568073484 no 2160 0.371700466641689 3066 719745
SGTC_2743 auranofin 4.32 µM -0.327562968214918 0.36326043937995 no 2161 0.371621062731657 3014 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_656 4090-1979 187 µM -0.328974972148976 0.362735259638721 no 2162 0.371087302710968 3113 22330961
SGTC_1716 st033144 30.6155 µM -0.328987144036799 0.3627307335561 no 2163 0.371082702619376 3156 674617
SGTC_56 0957-0365 83.25 µM -0.329536580232976 0.362526447216587 no 2164 0.370875074742647 3107 6752360
SGTC_1604 st002052 72.4 µM -0.329784772474509 0.362434179475949 no 2165 0.370781297051161 3116 6254834 YHR062C RPP1
SGTC_1460 k062-0059 9.15 µM -0.330031398085439 0.362342502059054 no 2166 0.370688118902882 2879 1373085
SGTC_677 0929-0063 136 µM -0.3310011094043 0.361982110694475 no 2167 0.370321823780904 3018 1539583
SGTC_2794 7785382 27.27 µM -0.331113035848884 0.361940521314057 no 2168 0.370279552666237 3068 2205081
SGTC_2938 9059746 27.26 µM -0.331910198365816 0.361644360611014 no 2169 0.369978534674576 3102 6471769
SGTC_617 3770-0098 35 µM -0.332087288183809 0.361578579691814 no 2170 0.369911674269936 3010 5962639
SGTC_65 0798-0905 34.986 µM -0.332158566641038 0.361552104098639 no 2171 0.369884764140188 3386 3602145
SGTC_3166 9102297 49.47 µM -0.332362392886297 0.361476398756499 no 2172 0.369807816065165 3045 25237072
SGTC_941 3237-0776 460 µM -0.333913479348433 0.360900470565798 no 2173 0.369222423986241 3176 760008
SGTC_66 0109-0187 42.4 µM -0.335216905374163 0.360416743961043 no 2174 0.368730735208275 2934 759417
SGTC_401 neomycin 50 µM -0.336178719370757 0.360059939335811 no 2175 0.368368049731607 3040 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2814 7977482 42.97 µM -0.336979766790267 0.359762867379708 no 2176 0.368066076373482 3150 6456762
SGTC_2105 5350118 200 µM -0.337380966327548 0.359614112592804 no 2177 0.367914865547166 3017 2133313
SGTC_455 paf C-16 10 µM -0.337492487377575 0.359572767144209 no 2178 0.367872837253231 2987 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_644 1498-1197 63.3 µM -0.33871029741581 0.359121381855316 no 2179 0.367413991267648 3100 6741615
SGTC_901 1112-0062 60.1 µM -0.339342514316167 0.358887126066222 no 2180 0.367175859412818 3008 1908457
SGTC_216 k038-0035 28.382 µM -0.339518946809881 0.358821761872161 no 2181 0.367109413173689 3089 4444231 YPR107C YTH1
SGTC_1694 st024011 44.9 µM -0.342027781529027 0.357892744306297 no 2182 0.366164992532732 3101 2787533
SGTC_927 2425-1185 123 µM -0.342550774616001 0.35769918653924 no 2183 0.365968219936576 2970 730375
SGTC_2285 7945142 200 µM -0.344021244996078 0.357155167202787 no 2184 0.365415154480415 3124 2970608
SGTC_1789 tunicamycin 25 nM -0.344064722432475 0.357139086581439 no 2185 0.3653988062317 3127 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2233 sulbentine 40.3845 µM -0.344108166993342 0.357123018372946 no 2186 0.365382470589013 3072 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2406 ethylparaben 405.7 µM -0.346053695283023 0.356403714235315 no 2187 0.364651180853121 2909 8434 A possible steroid mimic.
SGTC_2386 9075165 157.42 µM -0.346489745519462 0.356242566922435 no 2188 0.364487344699433 3006 16452277
SGTC_2763 lisinopril 49.32 µM -0.348094024234051 0.355649908670001 no 2189 0.363884786003422 3047 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2439 5492030 7.2 µM -0.348476769268313 0.355508565140601 no 2190 0.36374107862134 3116 5722370
SGTC_2774 tamoxifen 10.92 µM -0.350794490071494 0.354653081422308 no 2191 0.362871265571846 3026 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_422 cantharidin 155 µM -0.351810702891836 0.354278222332056 no 2192 0.36249011566769 2958 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2127 5253358 187.912 µM -0.351845460739949 0.354265403402522 no 2193 0.362477081484812 2945 20612
SGTC_2722 naftopidil 47.16 µM -0.352530245952079 0.354012883673244 no 2194 0.362220319753892 3147 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2142 5622915 118.518 µM -0.35309334363177 0.353805285233854 no 2195 0.362009231463124 3065 5322196
SGTC_2914 7968218 45.32 µM -0.353397683230529 0.353693101784898 no 2196 0.361895161217749 3114 2977111
SGTC_2044 5102272 200 µM -0.353848367664388 0.353526997106701 no 2197 0.361726261656058 3118 592666
SGTC_618 k072-0232 33.2 µM -0.356026157184149 0.352724742447187 no 2198 0.360910488171853 3105 5872756 YGL099W LSG1
SGTC_1155 4088-0394 48.2 µM -0.357294297717909 0.352257885787351 no 2199 0.360435749205108 3001 2326248
SGTC_147 4466-0538 29.23 µM -0.357818810745774 0.352064855171079 no 2200 0.360239456217419 3249 6742687 YHR072W ERG7
SGTC_472 calcifediol 10 µM -0.358382218369876 0.351857553073238 no 2201 0.360028648409877 3085 5283731 A vitamin D metabolite.
SGTC_1409 3909-8004 61.9 µM -0.359839991795824 0.35132137949522 no 2202 0.359483397269431 3080 2119279
SGTC_348 k064-0012 10.7 µM -0.361224769331012 0.350812327903796 no 2203 0.358965713599522 2989 5066323
SGTC_3299 9121982 43.1275 µM -0.361824847945983 0.350591818892151 no 2204 0.358741461237985 3069 17594604 YPL160W CDC60
SGTC_600 1495-0418 41.6 µM -0.361864139314767 0.350577382370693 no 2205 0.358726779555624 3044 5377768
SGTC_2094 5332512 191.667 µM -0.362268189881884 0.350428937742587 no 2206 0.358575813420136 3183 755774
SGTC_3328 9140624 29.0385 µM -0.363197333305912 0.350087665300038 no 2207 0.358228739765133 3184 4904392
SGTC_2647 atorvastatin 60.16 µM -0.364171282921864 0.349730065566623 no 2208 0.357865054852615 3095 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.364355426449189 0.349662469570483 no 2209 0.357796307855096 3012 15053
SGTC_2640 pentamidine 10.38 µM -0.365172774373765 0.349362492426065 no 2210 0.357491219971307 3157 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2250 alverine citrate 130 µM -0.366932121917533 0.348717108733896 no 2211 0.356834825154205 3063 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.369010265635721 0.34795534434537 no 2212 0.35606003653515 3244 94937 An inhibitor of serotonin biosynthesis.
SGTC_2860 9025725 38.96 µM -0.372673993527264 0.346613863223331 no 2213 0.354695547233653 3009 40546248
SGTC_722 3534-0461 190 µM -0.37304218887901 0.346479153738841 no 2214 0.354558522214831 3089 658262
SGTC_525 k781-2675 26.7 µM -0.374128654347649 0.346081768176167 no 2215 0.354154300547967 3146 3651118 YDL195W SEC31
SGTC_2080 5212524 12.4 µM -0.376351003604164 0.345269449944045 no 2216 0.353327983145368 3182 260183
SGTC_2183 6420625 130.508 µM -0.37637946841268 0.345259050033889 no 2217 0.35331740378882 3123 2897619
SGTC_1917 st066507 28.5 µM -0.377376347401101 0.344894903808699 no 2218 0.352946970882263 3051 3156428
SGTC_1007 4101-0031 70 µM -0.378740423712473 0.344396858198836 no 2219 0.35244031597655 3205 1146276
SGTC_2354 9060492 162 µM -0.382482517322827 0.343031948117927 no 2220 0.351051747052464 3229 6471895
SGTC_626 0214-0009 33 µM -0.382952445474649 0.342860688371732 no 2221 0.350877512056734 3216 3437874
SGTC_2854 9024559 71.43 µM -0.38311726464245 0.342800629624601 no 2222 0.350816409571763 3158 3163529
SGTC_1115 galangin 695.678 nM -0.384104694498698 0.342440901557476 no 2223 0.350450426089143 3243 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2058 5236698 133 µM -0.384634873838746 0.34224781219897 no 2224 0.350253976330368 3100 766665
SGTC_1643 st009866 20.2 µM -0.384798336081792 0.342188288167682 no 2225 0.350193415999835 3180 3156273 YOR207C RET1
SGTC_1124 fisetin 1.16336 µM -0.387143275367207 0.341334821414412 no 2226 0.349325070801234 3134 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2140 5586273 200 µM -0.38741662101915 0.341235386909559 no 2227 0.349223900453871 3152 854421
SGTC_1350 1495-0454 146 µM -0.388155355652317 0.340966713774374 no 2228 0.34895053454358 3237 1069057
SGTC_1084 voriconazole 435 nM -0.388339652119542 0.340899698871109 no 2229 0.348882348554889 3195 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_529 4076-0302 30.3 µM -0.38846364452387 0.340854614890235 no 2230 0.348836476603274 3087 5816522
SGTC_697 0508-1955 564 µM -0.389255004882367 0.340566927644094 no 2231 0.348543758776982 3243 6243113
SGTC_1699 st031318 29.054 µM -0.390704116769426 0.340040365119414 no 2232 0.34800797776398 3193 5340658
SGTC_2581 avocatin a 64 µM -0.391184938910331 0.339865718052074 no 2233 0.347830270061611 3109 6710728 A skin care supplement.
SGTC_2665 lovastatin 100 µM -0.392570215735519 0.339362741832439 no 2234 0.347318470711588 3137 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2373 9071805 200 µM -0.39312438000636 0.339161611957898 no 2235 0.347113809063832 3255 10149009
SGTC_866 0495-0101 262 µM -0.39531186841159 0.338368126943144 no 2236 0.346306370757441 3084 635694
SGTC_599 1935-0052 86.5 µM -0.396277279942421 0.338018163454511 no 2237 0.345950243109284 3083 9557311
SGTC_2512 diallyl trisulfide 49.23 µM -0.396363354909411 0.337986967908285 no 2238 0.345918497793018 3162 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_44 0929-0055 61.211 µM -0.396565708658744 0.33791363464159 no 2239 0.345843871954881 3067 1379590
SGTC_2356 9061756 188.97 µM -0.397470928833044 0.337585656995377 no 2240 0.345510110054398 3156 20104043
SGTC_3252 9135871 49.47 µM -0.39782070655821 0.337458959216625 no 2241 0.345381176363763 3238 17682838
SGTC_650 1328-0195 38 µM -0.398069852770819 0.337368723791038 no 2242 0.345289348005342 3205 2780821
SGTC_988 1497-1057 103 µM -0.39936964640388 0.336898118132154 no 2243 0.344810428050151 3221 3533044
SGTC_3061 glucosamine 200 µM -0.404127040205365 0.335177828649592 no 2244 0.343059650842681 3228 91431 and experimental redox chemotherapeutic
SGTC_2040 5100729 123 µM -0.404346470652347 0.335098564862982 no 2245 0.342978978717724 3106 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1228 0124-0032 52.5 µM -0.405537970477338 0.334668293477798 no 2246 0.342541056869387 3199 X1228
SGTC_3068 9116768 49.47 µM -0.405629363102671 0.334635298959691 no 2247 0.342507475306234 3221 41904888
SGTC_347 4534-1311 26.2 µM -0.406077496987291 0.334473532382662 no 2248 0.342342829754192 3110 2862016
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.408888089665052 0.333459671331971 no 2249 0.341310894984567 3154 6708561
SGTC_1728 st035614 33.7865 µM -0.409537482937007 0.333225589203116 no 2250 0.341072632629409 3166 15945546
SGTC_956 1185-0240 191 µM -0.409874272778594 0.333104214557978 no 2251 0.34094908940006 3119 1416193
SGTC_1851 st056236 18.9 µM -0.409892305070507 0.333097716449185 no 2252 0.340942475169606 3293 5393171
SGTC_327 1273-0057 3.96 µM -0.410213852873731 0.332981852039224 no 2253 0.340824539898955 3138 3108138
SGTC_1867 st057372 64 µM -0.411013718513153 0.332693702919404 no 2254 0.34053123773117 3194 688837
SGTC_2286 7945697 125 µM -0.411126378123006 0.332653125578473 no 2255 0.340489934400419 3177 1245733
SGTC_1157 4092-0394 27.6 µM -0.412236482356619 0.332253397048949 no 2256 0.340083049714547 3312 3659885
SGTC_840 0245-0196 390 µM -0.412260210833764 0.332244854932665 no 2257 0.340074354585308 3264 3827528
SGTC_1076 itraconazole 331 nM -0.412615906751526 0.332116816880494 no 2258 0.339944022579127 3195 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_289 k017-0060 526 µM -0.413811766186904 0.33168649320546 no 2259 0.339505983127419 3139 5512909
SGTC_1483 3453-0561 55.9 µM -0.414028689408691 0.331608458307136 no 2260 0.339426548057135 3210 4546991
SGTC_3023 9089636 49.47 µM -0.416429305967809 0.330745360823699 no 2261 0.338547943787792 3247 17249241
SGTC_2703 st077852 53.4 µM -0.41672905760582 0.330637653689352 no 2262 0.338438298925873 3235 6281836
SGTC_2443 5493264 126.67 µM -0.41683140915744 0.330600879812676 no 2263 0.33840086332836 3259 5340055
SGTC_2870 9038528 12.99 µM -0.417020992077176 0.330532768908116 no 2264 0.338331526636014 3243 6463316
SGTC_407 eburnamonine 100 µM -0.418515158314834 0.32999616072477 no 2265 0.337785253042443 3100 3195
SGTC_97 0535-0701 19.132 µM -0.420992818170655 0.329107115919616 no 2266 0.336880163086207 3164 2832013 YGL099W LSG1
SGTC_182 3448-4371 550.524 µM -0.421409784332808 0.328957593085583 no 2267 0.336727937846324 3243 3491403
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.421452193121108 0.32894238695221 no 2268 0.336712456821957 3240 7104
SGTC_2825 7998094 58.44 µM -0.421684315043873 0.328859162122306 no 2269 0.336627727279405 3167 2987815
SGTC_2493 resveratrol 26.09 µM -0.421895438054953 0.328783473595487 no 2270 0.336550669997217 3095 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2796 7949634 45.45 µM -0.421951566413053 0.328763352514008 no 2271 0.336530184996979 3106 2971588
SGTC_1250 0485-0349 40.2 µM -0.423658330634628 0.328151743227556 no 2272 0.335907504249444 3147 6842794 YDL195W SEC31
SGTC_1037 k284-1091 78.7 µM -0.423975730074891 0.328038055660849 no 2273 0.33579175663649 3182 3334711
SGTC_3149 9097855 49.47 µM -0.42537097019288 0.327538491289477 no 2274 0.335283132412719 3265 25236625 YMR079W SEC14
SGTC_1657 st012939 43.4 µM -0.426429022671254 0.327159862316848 no 2275 0.334897628540428 3275 24207257
SGTC_2351 9026858 72.31 µM -0.428595745699506 0.326385045658287 no 2276 0.334108721047867 3089 1409300
SGTC_148 3253-0744 288.01 µM -0.429535109112527 0.326049363227828 no 2277 0.333766924629476 3235 6893655
SGTC_478 N-arachidonylglycine 10 µM -0.430313232177211 0.325771406886201 no 2278 0.333483901466441 3208 5283389
SGTC_278 4092-0821 23.9 µM -0.430752763650647 0.32561444293456 no 2279 0.333324074550301 3235 877900
SGTC_3063 1327-0034 4 µM -0.432041938190323 0.325154235810726 no 2280 0.332855466374105 3235 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2528 xanthyletin 44.79 µM -0.432375191636901 0.3250353149513 no 2281 0.332734372914297 3130 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2714 st079313 56.9 µM -0.43456226957093 0.324255303110776 no 2282 0.331940093433766 3171 2939799
SGTC_3027 9089541 49.47 µM -0.436750600435012 0.323475615607964 no 2283 0.331146114118067 3256 9943819
SGTC_959 1222-0044 107 µM -0.43705890127046 0.323365832265036 no 2284 0.331034316011166 3280 6083612
SGTC_1608 st001473 40.5 µM -0.43922399951939 0.32259529256061 no 2285 0.330249618455867 3179 7292267
SGTC_2571 chrysanthemic acid 100 µM -0.44084534509075 0.322018767991636 no 2286 0.329662481677561 3194 2743 An insecticide.
SGTC_1986 st071812 45 µM -0.441305462457706 0.321855235528304 no 2287 0.329495936050833 3251 11838594
SGTC_2999 9069765 71.4286 µM -0.441701877853354 0.321714371343197 no 2288 0.329352475318351 3214 2097066
SGTC_2195 6536160 144.242 µM -0.443741202160252 0.320990113218311 no 2289 0.328614851505213 3156 3834386
SGTC_775 4577-0580 57.3 µM -0.444039000458203 0.320884408189021 no 2290 0.328507193599772 3375 2006902
SGTC_2852 9023854 51.95 µM -0.445457471665876 0.320381113960115 no 2291 0.327994593576609 3336 19798528
SGTC_1721 st082152 9.2685 µM -0.445896138833402 0.320225535265321 no 2292 0.327836135743938 3206 5296051
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.447168762834293 0.319774362430767 no 2293 0.327376606773158 3254 1241132 A phosphatase inhibitor.
SGTC_1161 k007-0610 110 µM -0.448138371099406 0.319430794095815 no 2294 0.327026668520832 3324 5843850
SGTC_651 3253-0966 34.4 µM -0.449978618477615 0.318779152199205 no 2295 0.326362928940323 3204 781462
SGTC_707 0865-0008 204 µM -0.453441031299612 0.317554611349017 no 2296 0.325115598175865 3185 723043
SGTC_1298 1079-1278 263 µM -0.453828419494969 0.317417728723967 no 2297 0.324976163459478 3268 2840950
SGTC_475 α-linolenic acid 10 µM -0.454476584167375 0.317188757235753 no 2298 0.32474292088747 3419 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1401 3807-4679 7.6 µM -0.454499363457544 0.317180711466454 no 2299 0.324734724990948 3271 3291456
SGTC_1680 diphenhydramine 100 µM -0.455095996830407 0.316970008092427 no 2300 0.324520088941808 3200 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_4 0960-0234 25.671 µM -0.456496073033369 0.316475798885317 no 2301 0.324016647031275 3292 6821112
SGTC_2489 cantharidin 73.42 µM -0.456651699827617 0.316420884804336 no 2302 0.323960706319837 3280 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2349 9023730 187.07 µM -0.457484337633249 0.316127151091748 no 2303 0.323661478687018 3345 4126287
SGTC_954 1189-0853 2.85 µM -0.459405944303108 0.315449699567891 no 2304 0.322971340192634 3279 2828194
SGTC_2745 rifampicin 24.3 µM -0.459482410357866 0.315422754703802 no 2305 0.322943890254772 3235 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_609 0986-0026 86.3 µM -0.460423669879087 0.315091157119837 no 2306 0.322606074064195 3212 2848610
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.46156509952997 0.314689241177361 no 2307 0.322196613601641 3373 5393153
SGTC_2686 alizarin 95.37 µM -0.462789077747908 0.314258502355102 no 2308 0.321757780459675 3230 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2098 5376439 882.5 nM -0.463019141322656 0.314177567266446 no 2309 0.321675323451834 3298 2844116
SGTC_1138 3761-0006 1.03 µM -0.463418181001308 0.314037208512161 no 2310 0.321532324606628 3315 12061087
SGTC_1713 st033146 12.748 µM -0.465175144570953 0.313419531920587 no 2311 0.320903018355511 3362 674619
SGTC_3204 9114183 49.47 µM -0.465584557621715 0.313275674082447 no 2312 0.320756449281995 3150 17027248
SGTC_1523 st012844 44.7 µM -0.466680496459171 0.31289072754937 no 2313 0.320364242846651 3343 4274103
SGTC_1620 st003704 16.5 µM -0.468486562383376 0.312256795224533 no 2314 0.319718339148695 3347 2834414
SGTC_908 3448-7491 47.7 µM -0.46855854171349 0.312231541849281 no 2315 0.319692608475962 3223 1203031
SGTC_2857 9024691 58.44 µM -0.472879809772363 0.310717079020605 no 2316 0.318149465112442 3304 16478292
SGTC_443 clozapine 122 µM -0.474176708257445 0.310263182044005 no 2317 0.317686950653695 3296 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1006 4099-6547 255 µM -0.474348944215304 0.310202923496524 no 2318 0.317625547313369 3348 3146833
SGTC_2139 5578692 56.4705 µM -0.474628967284593 0.310104965380653 no 2319 0.317525727811894 3297 650991 YMR113W FOL3
SGTC_1553 gossypol 38.6 µM -0.475347122618363 0.309853800745696 no 2320 0.317269788458226 3267 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_976 1348-1067 47.6 µM -0.475897295744489 0.309661445520515 no 2321 0.317073774432289 3258 5310671 YGL099W LSG1
SGTC_637 1181-0519 7.26 µM -0.476234928822819 0.309543425777097 no 2322 0.316953508940535 3314 6252091 YGR060W ERG25
SGTC_948 3448-0295 75.3 µM -0.477551917375163 0.30908325981626 no 2323 0.316484580230854 3302 678569
SGTC_510 ag-490 170 µM -0.47784817963206 0.308979784724153 no 2324 0.316379133293714 3380 5328779
SGTC_933 2914-0560 114 µM -0.478904973591778 0.308610803321885 no 2325 0.316003116279121 3371 463887
SGTC_1354 1498-1681 81 µM -0.479247142544529 0.308491375831505 no 2326 0.315881410174824 3323 5754243
SGTC_1091 telmisartan 47.6 µM -0.479478877287947 0.308410504783246 no 2327 0.315798995757622 3358 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2383 9036125 200 µM -0.479686134825822 0.308338183691901 no 2328 0.315725294199555 3221 79580
SGTC_2243 6634756 200 µM -0.480476357046063 0.30806250934833 no 2329 0.31544435545834 3423 885676
SGTC_1479 0549-0158 134 µM -0.481421987577628 0.307732762058031 no 2330 0.315108306345266 3295 5440202
SGTC_3130 9127414 49.47 µM -0.482714523027961 0.307282297992013 no 2331 0.314649224940986 3322 1494646
SGTC_973 1325-0077 65.9 µM -0.483874296381025 0.306878350424475 no 2332 0.314237541560338 3274 2835149
SGTC_1269 0831-0796 3.05 µM -0.483913451970634 0.306864716670171 no 2333 0.314223646574938 3358 927758
SGTC_3256 9138902 49.47 µM -0.486526765954247 0.305955380185843 no 2334 0.313296866408225 3292 17228773
SGTC_914 3820-6779 408 µM -0.487120044008061 0.305749107595409 no 2335 0.313086631372134 3224 2893481
SGTC_1357 1503-1303 39.5 µM -0.489715727179084 0.304847358320866 no 2336 0.312167535662024 3288 292895
SGTC_11 0438-0307 1.3 µM -0.492016972118601 0.304048887775945 no 2337 0.311353672744176 3364 4011476
SGTC_846 0335-0850 148 µM -0.493887245570859 0.303400640363562 no 2338 0.3106929063293 3326 6819598
SGTC_2524 avocatin b 10.57 µM -0.494887861266118 0.303054075046273 no 2339 0.310339639842031 3308 6710748
SGTC_2511 berberine 10.47 µM -0.49569993562537 0.302772941677702 no 2340 0.310053066259846 3260 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1344 1488-0097 29.1 µM -0.496756755468455 0.302407254483419 no 2341 0.30968029697989 3360 747966
SGTC_1463 k081-0032 34.1 µM -0.497557128085582 0.302130436593268 no 2342 0.309398113830807 3300 977755
SGTC_1106 tegaserod maleate 11.7 µM -0.499413530721325 0.301488817170551 no 2343 0.308744044488226 3307 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2770 toltrazuril 17.5 µM -0.499612660196218 0.30142002944543 no 2344 0.308673920843293 3384 68591 Kills coccidiodes.
SGTC_2225 6654152 15.4 µM -0.499759965548844 0.301369148505715 no 2345 0.308622051604055 3330 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3014 9081533 49.47 µM -0.499827871698174 0.30134569425365 no 2346 0.308598141740351 3381 21367265
SGTC_923 1900-2434 73.3 µM -0.500113842169933 0.301246931312035 no 2347 0.30849745998599 3322 5910570
SGTC_3174 9107204 49.47 µM -0.50068026757251 0.30105135332906 no 2348 0.308298080845421 3399 3938802
SGTC_2614 arthonioic acid 13.39 µM -0.500983696199132 0.300946607635499 no 2349 0.308191298613801 3336 6710684
SGTC_1452 4194-0072 190 µM -0.501602862139115 0.300732918198867 no 2350 0.307973452852973 3410 1343545
SGTC_878 0828-0289 13.7 µM -0.501639697012085 0.300720207733825 no 2351 0.30796049509676 3296 745350 YLR208W SEC13
SGTC_1165 k072-0275 30.3 µM -0.504057117350075 0.299886568616394 no 2352 0.307110620080377 3411 6153523 YGL055W OLE1
SGTC_952 1185-0122 232 µM -0.504814265114014 0.299625684095436 no 2353 0.306844647772715 3321 678600
SGTC_2215 7188065 200 µM -0.506057365478209 0.29919758182755 no 2354 0.306408189590181 3397 940217
SGTC_1687 st020778 55.3625 µM -0.506356170216645 0.299094720036589 no 2355 0.3063033187888 3339 4259299
SGTC_205 1486-1330 71.903 µM -0.506385495757799 0.299084625754986 no 2356 0.306293027326953 3329 4118834
SGTC_2786 7743617 45.45 µM -0.506657939291114 0.298990854086628 no 2357 0.30619742370415 3278 583674
SGTC_2627 acetyl isogambogic acid 100 µM -0.508873931480775 0.29822863367853 no 2358 0.30542029675891 3350 6857789 A caspase activator and apoptosis inducer.
SGTC_1423 4048-0112 5.59 µM -0.510803199512932 0.2975657573816 no 2359 0.304744434279447 3382 X1423
SGTC_2213 7173844 200 µM -0.51104744674984 0.297481884574847 no 2360 0.304658916859236 3306 892728
SGTC_858 0438-0351 2.77 µM -0.512844789973667 0.296865021654864 no 2361 0.304029947954027 3338 2799119
SGTC_2468 5987765 72.9 µM -0.512948127001397 0.296829573342626 no 2362 0.303993803416252 3324 26772094
SGTC_2973 9094665 17.96 µM -0.514078729874486 0.29644186256653 no 2363 0.303598473877491 3439 25237061 YIL048W NEO1
SGTC_440 fluspirilene 35.1 µM -0.515814455103786 0.295847092994939 no 2364 0.302992002834597 3468 3396 An atypical antipsychotic.
SGTC_2087 5276107 200 µM -0.517132813917985 0.295395706222088 no 2365 0.302531724295707 3348 144405
SGTC_2171 5739187 198.077 µM -0.517599580121194 0.295235968282623 no 2366 0.302368837400417 3230 2262761
SGTC_3282 9108498 15.4605 µM -0.518020629800387 0.295091909690492 no 2367 0.302221937906433 3364 16459645
SGTC_134 0269-0018 6.916 µM -0.518518845906135 0.294921491085866 no 2368 0.302048157298652 3334 4378915
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.518885232345849 0.294796194767934 no 2369 0.301920388268421 3351 77254
SGTC_1039 k821-0043 94 µM -0.518985847637709 0.294761790787919 no 2370 0.301885305198635 3409 15992768
SGTC_794 k038-0031 316 µM -0.519504993377277 0.294584305650708 no 2371 0.301704315845442 3435 6624242
SGTC_227 fluconazole 33.516 µM -0.519661090249207 0.29453094901821 no 2372 0.301649905463193 3349 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_203 k066-0004 30.888 µM -0.520063550330143 0.294393401721582 no 2373 0.301509641098673 3421 6795412
SGTC_527 4476-4215 268 µM -0.521605284061571 0.293866763685622 no 2374 0.300972591737058 3285 4418754
SGTC_791 1348-1292 225 µM -0.523570794649357 0.293196001101015 no 2375 0.300288549577837 3402 5437054
SGTC_548 1436-0017 110 µM -0.523852750511041 0.2930998373072 no 2376 0.300190480216815 3462 9677137
SGTC_304 1310-0298 97 µM -0.523901530212213 0.293083201999255 no 2377 0.3001735152218 3381 1550234
SGTC_1064 honokiol 6.76 µM -0.524058970781716 0.293029513138064 no 2378 0.300118762238038 3360 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.5245272551644 0.29286985029826 no 2379 0.299955934048548 3384 1273210
SGTC_1259 0671-0132 43 µM -0.524572751264081 0.292854340431183 no 2380 0.299940116630913 3277 X1259
SGTC_354 2783-3500 4.88 µM -0.52484161597799 0.292762690777764 no 2381 0.299846649392727 3296 6740761
SGTC_2446 5162541 200 µM -0.525038063653772 0.292695734810185 no 2382 0.299778365311863 3322 1549321
SGTC_800 3448-7362 155 µM -0.525189138341908 0.292644248319522 no 2383 0.299725857410675 3445 15991913
SGTC_1634 st006576 41 µM -0.52587864503915 0.292409316792255 no 2384 0.299486263625596 3452 3915356
SGTC_476 mead acid 10 µM -0.526781670252273 0.29210176705498 no 2385 0.299172606573159 3331 5312531 An omega 9 fatty acid.
SGTC_1813 st051246 8.6015 µM -0.528871999549167 0.291390426915973 no 2386 0.298447123571293 3372 5291959
SGTC_2759 disulfiram 3.38 µM -0.529281238101599 0.291251257488953 no 2387 0.298305184389124 3311 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1561 5-methoxyflavone 52.9 µM -0.530324012802731 0.290896782260415 no 2388 0.29794365026087 3390 94525
SGTC_215 1287-0124 461.5 µM -0.530729721571929 0.290758922308695 no 2389 0.297803043415023 3369 5560863
SGTC_830 4076-0286 57.8 µM -0.531524311188894 0.2904890090828 no 2390 0.297527749510567 3418 6866659
SGTC_2413 inermin 26.06 µM -0.531960606935673 0.290340854177972 no 2391 0.297376639703536 3512 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_558 k064-0027 21.3 µM -0.533238470204429 0.289907128125294 no 2392 0.296934257189331 3380 5088526
SGTC_2624 nerol 100 µM -0.533977905994628 0.289656291339403 no 2393 0.296678410076388 3378 637566 A natural product oil.
SGTC_690 glyoxal 20.3 µM -0.534256377576625 0.289561852597815 no 2394 0.296582084206757 3369 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1766 st045414 44.774 µM -0.534436541693239 0.289500760808388 no 2395 0.296519771423664 3431 253960
SGTC_3259 9138485 49.47 µM -0.53516905536648 0.289252435353259 no 2396 0.296266481078155 3579 17646153
SGTC_742 0kpi-0133 140 µM -0.536763884440573 0.288712127635942 no 2397 0.295715360726847 3438 2728852
SGTC_3304 9125678 46.087 µM -0.538764224789987 0.288035110554654 no 2398 0.295024775855046 3354 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2380 9035439 200 µM -0.539731019448948 0.287708166809209 no 2399 0.294691272286843 3487 6462575
SGTC_1053 3366-3204 134 µM -0.541490737820554 0.287113528237534 no 2400 0.294084690012485 3364 3632071 YPR165W RHO1
SGTC_29 0299-0004 12.984 µM -0.543457248385398 0.286449700394512 no 2401 0.293407509210499 3347 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2635 hydroquinidine 100 µM -0.544258714575395 0.286179361423577 no 2402 0.293131726442406 3401 442912 An experimental heart treatment.
SGTC_488 nitrendipine 139 µM -0.544282096906825 0.286171476253711 no 2403 0.293123682438161 3427 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1142 3253-1408 9.78 µM -0.546308945510939 0.28548835925698 no 2404 0.292426794097632 3451 256655
SGTC_497 capsazepine 133 µM -0.546861599608969 0.285302230795325 no 2405 0.292236909590005 3358 2733484 A calcium channel blocker.
SGTC_32 0928-0142 34.1 µM -0.547280827268468 0.285161077614396 no 2406 0.29209290688015 3424 2244242
SGTC_3230 9131665 49.47 µM -0.548015499877059 0.284913795003173 no 2407 0.291840630012637 3378 15943720
SGTC_847 0342-0274 5.54 µM -0.548019433557513 0.284912471245525 no 2408 0.291839279511975 3441 18097
SGTC_2876 9059903 25.97 µM -0.548476208195352 0.284758777919452 no 2409 0.291682480664187 3440 6916095
SGTC_2144 5628481 200 µM -0.549297471995182 0.284482542606661 no 2410 0.291400660982818 3384 2818399
SGTC_1082 camptothecin 424.86 nM -0.549513005541399 0.284410068260453 no 2411 0.291326720907541 3240 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_35 0133-0054 64.071 µM -0.549641915824629 0.284366725681697 no 2412 0.291282501646814 3370 99677
SGTC_1242 0402-0103 60.1 µM -0.550414954542805 0.284106878664798 no 2413 0.291017396919533 3403 432868
SGTC_274 sirtinol 40.1 µM -0.550510995504948 0.284074603664016 no 2414 0.290984468651073 3410 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3001 9076041 71.4286 µM -0.552751766828047 0.283322080557287 no 2415 0.290216700226519 3434 16004211
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.554932831057 0.282590528328275 no 2416 0.289470302279949 3384 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1661 st013063 9.66 µM -0.555766576805756 0.28231112118933 no 2417 0.289185218444008 3443 721395
SGTC_3346 9158254 43.5805 µM -0.556110563226469 0.282195882271794 no 2418 0.289067637168785 3418 17639500
SGTC_1018 4259-0013 28.1 µM -0.556774115055407 0.281973649707054 no 2419 0.288840885742089 3451 6801262
SGTC_171 k064-0041 9.68 µM -0.557833411081314 0.281619051812233 no 2420 0.288479072731741 3365 53325
SGTC_1980 st071811 45.7 µM -0.559598057791987 0.281028816683964 no 2421 0.287876814971394 3519 4974850
SGTC_758 0868-0029 16 µM -0.559876765393365 0.28093564986676 no 2422 0.287781748942788 3478 762687
SGTC_3189 9110682 49.47 µM -0.560521444957957 0.280720202583087 no 2423 0.287561908212604 3446 17122418
SGTC_1539 benzyladenosine 56 µM -0.561332835817396 0.28044915521631 no 2424 0.287285330537226 3395 92208 A nucleotide analog.
SGTC_2738 aclarubicin 5.55 µM -0.561626580719032 0.280351060161716 no 2425 0.287185233164237 3358 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1877 wortmannin 25 µM -0.562781951211604 0.279965389616213 no 2426 0.286791685985925 3494 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1176 0848-0131 83.3 µM -0.564642355548025 0.279344915096136 no 2427 0.286158524943798 3455 6769040
SGTC_5 0352-0601 109.883 µM -0.565639860504882 0.279012506646842 no 2428 0.285819312591028 3405 762456
SGTC_322 k048-0136 19.3 µM -0.567302715806578 0.278458804940771 no 2429 0.285254266110941 3471 6823282
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.567872541186349 0.278269186306804 no 2430 0.285060759135187 3484 5024745
SGTC_210 3551-0445 56.827 µM -0.568677878607522 0.27800130462386 no 2431 0.284787381412702 3515 2865180 YOR207C RET1
SGTC_2096 5468907 200 µM -0.568741447583756 0.277980164853529 no 2432 0.284765807783846 3451 759785
SGTC_663 1486-0733 13.9 µM -0.569318909394859 0.277788166707286 no 2433 0.28456986825259 3413 722445 YPR165W RHO1
SGTC_997 3996-0078 137 µM -0.571130222845597 0.277186350215291 no 2434 0.283955686516712 3419 735687
SGTC_1070 indatraline 8.81 µM -0.571211085287624 0.277159498210538 no 2435 0.28392828240751 3435 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2430 5571206 200 µM -0.574452267330159 0.276084247490723 no 2436 0.282830896175857 3523 1731771
SGTC_1769 st044406 64.4 µM -0.574499506742913 0.276068591136765 no 2437 0.282814917121619 3394 670903
SGTC_1023 4482-3888 16 µM -0.576584386681019 0.275378042907852 no 2438 0.282110124484081 3515 3303168
SGTC_678 1218-2179 85.9 µM -0.578619181013303 0.274704904486043 no 2439 0.281423079706151 3469 6820081 YOR116C RPO31
SGTC_880 0833-0487 87.2 µM -0.578790041749443 0.274648418312604 no 2440 0.281365425640426 3469 76075
SGTC_3229 9132204 49.47 µM -0.579582002189597 0.274386672816944 no 2441 0.281098266458785 3468 17682924
SGTC_2136 5328288 199.296 µM -0.583171016668226 0.27320203753102 no 2442 0.279889090097159 3418 262395
SGTC_180 1486-1293 102.781 µM -0.583904973453719 0.272960090979078 no 2443 0.279642123447057 3558 4140536
SGTC_1133 3473-0247 50 µM -0.586524703107672 0.272097372623694 no 2444 0.278761482949186 3401 711311
SGTC_236 1509-0011 5.31 µM -0.586574039760115 0.272081138299456 no 2445 0.278744911046595 3560 3107280
SGTC_1033 k072-0102 21.3 µM -0.586766549930511 0.272017797048611 no 2446 0.278680252555637 3511 5965931
SGTC_3165 9101544 49.47 µM -0.587688788672313 0.271714456359112 no 2447 0.278370601076286 3502 5002184
SGTC_206 4546-0025 72.014 µM -0.588303617847947 0.27151232171831 no 2448 0.27816425883515 3510 6620745 YIL048W NEO1
SGTC_570 0987-0065 62.6 µM -0.58869300224308 0.271384344299396 no 2449 0.278033616496471 3396 3104428
SGTC_987 1497-1013 404 µM -0.58912201216288 0.271243378126419 no 2450 0.277889714069777 3499 1676435
SGTC_1581 himbacine 57.9 µM -0.589926949468645 0.270978986427813 no 2451 0.277619812783494 3441 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_726 3448-4391 34.2 µM -0.590994977488911 0.270628377893465 no 2452 0.2772618930989 3597 1356692
SGTC_551 k048-0028 34.9 µM -0.593552743529519 0.269789645399084 no 2453 0.276405648019376 3531 6836383
SGTC_2473 5854593 8.94 µM -0.593663905901075 0.269753223010558 no 2454 0.276368464412672 3461 2872951
SGTC_1797 st048695 56.8 µM -0.594248442221143 0.269561740016286 no 2455 0.276172978482793 3502 592262 YIL048W NEO1
SGTC_2671 danthron 100 µM -0.596586530912825 0.268796508285567 no 2456 0.275391733011508 3473 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2408 sulbentine 18.36 µM -0.596762266653328 0.26873903595139 no 2457 0.275333056899757 3377 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_410 α-linolenic acid 100 µM -0.596795273477288 0.26872824214137 no 2458 0.27532203699299 3551 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1562 morin hydrate 59.1 µM -0.5979315122112 0.268356805004884 no 2459 0.274942816181713 3554 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_384 k007-0144 5.16 µM -0.598486461166744 0.268175485752941 no 2460 0.274757695008649 3500 6824886
SGTC_64 000l-0018 272.079 µM -0.599719765517322 0.267772747362978 no 2461 0.274346506624073 3500 6811119
SGTC_765 1319-0117 244 µM -0.60124413519623 0.267275382370808 no 2462 0.273838696098511 3513 3487746 YGL099W LSG1
SGTC_2022 5136654 200 µM -0.601820118972622 0.267087574203592 no 2463 0.273646940717531 3510 1713771
SGTC_1994 st072947 40.9 µM -0.602810984443998 0.266764643605423 no 2464 0.273317219268704 3542 5286565 YDL195W SEC31
SGTC_667 1498-1044 59 µM -0.603139366341856 0.266657664997334 no 2465 0.273207989985705 3491 6739982
SGTC_2433 5607874 27.82 µM -0.608460122044293 0.264927324104089 no 2466 0.271441173383144 3520 2252428
SGTC_1871 st057448 67.3 µM -0.610499939722646 0.26426547983367 no 2467 0.270765341661015 3628 691747
SGTC_2377 9073351 62.6 µM -0.610696580427866 0.264201721828834 no 2468 0.270700235148663 3464 7337946 YHR072W ERG7
SGTC_1327 1436-0082 2.18 µM -0.611505327664222 0.263939579219877 no 2469 0.270432546193789 3484 15992205
SGTC_168 3970-0862 530.542 µM -0.611893784377851 0.263813714276616 no 2470 0.270304017132866 3544 3135186
SGTC_2421 5690543 90.72 µM -0.615684530527954 0.262587072675914 no 2471 0.269051374530331 3552 3397993
SGTC_306 1672-3436 11.6 µM -0.623278098328715 0.260138692033403 no 2472 0.266550893854591 3572 6797378
SGTC_3266 9136860 49.47 µM -0.624450122480892 0.259761849387171 no 2473 0.266166008390063 3490 4871271 YPR165W RHO1
SGTC_2643 anethole 100 µM -0.624868398128794 0.259627428845156 no 2474 0.266028717422217 3542 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2076 5212012 200 µM -0.625218334363683 0.259514998020257 no 2475 0.265913885121355 3478 604802
SGTC_1792 st045773 43.6 µM -0.629846428956598 0.258030408731444 no 2476 0.264397532698435 3522 2919270
SGTC_986 1493-0483 84 µM -0.6298661930516 0.258024078310268 no 2477 0.264391066625957 3533 40079
SGTC_34 0469-0683 81.75 µM -0.630985251161008 0.257665776489161 no 2478 0.264025084031355 3535 3690923
SGTC_1623 st003709 20.3 µM -0.631507440844997 0.257498669399426 no 2479 0.26385439277837 3565 16192618
SGTC_701 4424-0219 185 µM -0.631844551386812 0.25739081981061 no 2480 0.263744229338976 3611 2911779
SGTC_110 0850-0284 111.64 µM -0.633997945914155 0.256702452506873 no 2481 0.263041081319645 3462 3906265
SGTC_3064 1327-0027 10 µM -0.634006058497865 0.256699861002099 no 2482 0.263038434129916 3478 16000455 YPR107C YTH1
SGTC_2329 6138490 200 µM -0.634280688228852 0.256612140604919 no 2483 0.262948828664724 3555 720019
SGTC_2145 5634607 200 µM -0.634825971784222 0.256438016049119 no 2484 0.26277096124504 3536 308662
SGTC_2229 7354935 190 µM -0.635855000134602 0.256109585803414 no 2485 0.262435467618015 3530 318112
SGTC_2227 7312221 64.1025 µM -0.636287919288078 0.255971478577819 no 2486 0.262294388760209 3589 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_272 doxorubicin 8.13 µM -0.637061048177372 0.25572493641122 no 2487 0.262042539678346 3588 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2689 tacrolimus 100 µM -0.637528158795182 0.255576040157703 no 2488 0.261890437069062 3556 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2106 5357045 167.29 µM -0.639243271968027 0.255029719049673 no 2489 0.261332342972053 3554 668842
SGTC_192 3455-0609 60.9 µM -0.639638543571049 0.254903898459443 no 2490 0.261203809126795 3629 3769639
SGTC_3208 9114115 49.47 µM -0.640022765547999 0.254781626266598 no 2491 0.261078899526197 3522 650895
SGTC_1408 3909-7976 48.8 µM -0.640234260063961 0.254714334793017 no 2492 0.261010156294879 3591 24152374
SGTC_2576 guaiol 23.12 µM -0.64217547221693 0.254097131882675 no 2493 0.260379628390345 3580 227829
SGTC_1496 4469-0713 57.4 µM -0.642774718515723 0.253906761803535 no 2494 0.26018514494786 3575 746691
SGTC_1134 3477-0009 42.5 µM -0.643003543337231 0.253834087909754 no 2495 0.260110900352341 3643 3973534
SGTC_107 0358-0022 2.6945 µM -0.643013693519024 0.253830864503524 no 2496 0.260107607273183 3551 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_727 3032-0951 202 µM -0.643654332426852 0.253627459470928 no 2497 0.259899804774612 3553 3652836
SGTC_797 k781-0471 270 µM -0.645626881413521 0.253001706491148 no 2498 0.259260512014355 3568 23738129
SGTC_1710 st031758 61.5 µM -0.646028375311701 0.2528744398977 no 2499 0.259130489563319 3619 5394341
SGTC_280 3448-3607 3.04 µM -0.64660224226936 0.252692592558138 no 2500 0.258944703222534 3583 626179
SGTC_1015 4130-4525 82 µM -0.647721119541769 0.25233824012333 no 2501 0.258582670955963 3524 1363237
SGTC_2030 5175110 200 µM -0.650832479841086 0.251354239886621 no 2502 0.257577315588968 3640 2831986
SGTC_1672 st016598 6.51 µM -0.651435620634838 0.251163725291452 no 2503 0.25738266144938 3540 4665860 YNL267W PIK1
SGTC_1056 3448-1962 115 µM -0.651858934652219 0.251030058359753 no 2504 0.257246089218752 3581 715507
SGTC_3127 9126946 49.47 µM -0.652001273564739 0.250985121445665 no 2505 0.257200175408084 3520 27243249
SGTC_1809 st050081 57.6 µM -0.652668074225673 0.250774666735423 no 2506 0.256985144379901 3662 5036894
SGTC_2626 ethyl orsellinate 100 µM -0.653268795454386 0.250585147962393 no 2507 0.256791502872245 3592 75653 A natural product.
SGTC_2823 7987624 58.44 µM -0.655173796648729 0.249984650096342 no 2508 0.256177931531199 3646 2239440
SGTC_1588 farnesol 29.9 µM -0.657433481851199 0.249273339438669 no 2509 0.255451114402259 3633 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1041 0206-0046 107 µM -0.658117995034421 0.249058078841896 no 2510 0.255231156780626 3564 50494
SGTC_964 1287-0107 19.4 µM -0.659271843082387 0.248695449295032 no 2511 0.254860609999584 3624 51516812 YPR165W RHO1
SGTC_808 0711-0032 135 µM -0.659584099195994 0.248597362301762 no 2512 0.254760380498435 3592 4252555
SGTC_2332 7982454 138.89 µM -0.659824104437937 0.248521985017107 no 2513 0.254683356466286 3598 2981748
SGTC_3306 9127676 59.7925 µM -0.660107771790101 0.24843291068938 no 2514 0.254592335834692 3595 41905287
SGTC_3091 9116372 49.47 µM -0.660479572501153 0.248316187393828 no 2515 0.254473061570241 3623 17169793
SGTC_3293 9120939 62.045 µM -0.660712064459205 0.248243213615604 no 2516 0.25439849265883 3619 934087
SGTC_1477 0139-0234 16 µM -0.660729584786239 0.248237714858834 no 2517 0.254392873695341 3619 620880
SGTC_2667 digitoxin 100 µM -0.661191177241139 0.248092867410256 no 2518 0.254244859302392 3575 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1319 1306-0155 43.7 µM -0.661362876218257 0.248038999876175 no 2519 0.254189813774451 3638 3122360
SGTC_861 0443-0273 110 µM -0.662230662206203 0.247766842781747 no 2520 0.253911703113938 3609 6149169
SGTC_2497 7-hydroxyflavone 100 µM -0.66242223447876 0.247706782924022 no 2521 0.253850328981925 3608 5281894
SGTC_1693 xanthone 101.9 µM -0.662833234076624 0.247577956602655 no 2522 0.253718683055659 3634 7020 An insecticide.
SGTC_1132 3456-3614 2.5 µM -0.662842089250499 0.247575181374712 no 2523 0.253715847078681 3669 3125502
SGTC_1246 0422-0085 105 µM -0.667797445790445 0.246024773516677 no 2524 0.252131448609157 3620 264295
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.668904639440618 0.245679073471184 no 2525 0.251778155259648 3628 5377381
SGTC_1555 citronellol 128 µM -0.668952611457371 0.245664101024388 no 2526 0.251762853825329 3594 8842 A terpine precursor.
SGTC_2409 alverine citrate 63.97 µM -0.669153335875152 0.245601458657022 no 2527 0.251698834919932 3702 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2490 carminic acid 95.39 µM -0.669670955995208 0.245439958615965 no 2528 0.251533785199522 3579 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2721 ifenprodil 61.44 µM -0.670725829173239 0.24511100968462 no 2529 0.25119760264588 3633 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2526 patulin 37.61 µM -0.671084424249904 0.244999240347537 no 2530 0.251083374417421 3659 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2333 9017922 200 µM -0.671300282199209 0.244931973505677 no 2531 0.251014627463604 3649 3163164
SGTC_2580 diallyl disulphide 81.36 µM -0.671822057554958 0.244769416050921 no 2532 0.250848492349045 3633 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_979 1426-2828 121 µM -0.673682901919185 0.244190149119129 no 2533 0.250256467232086 3690 747872
SGTC_3000 9075062 71.4286 µM -0.674183246868286 0.244034521664502 no 2534 0.250097409644062 3620 17057871
SGTC_470 aa-861 153 µM -0.674490759476595 0.243938899395288 no 2535 0.249999679274407 3609 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_395 anisomycin 6.25 µM -0.675827280293799 0.243523537899323 no 2536 0.249575156061754 3595 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1906 st060206 94.7 µM -0.675998553864485 0.24347033744044 no 2537 0.249520781608345 3632 5133468
SGTC_1261 0712-0010 12.7 µM -0.676749305896678 0.24323721529809 no 2538 0.249282513624853 3652 2840123
SGTC_1804 st050076 49.1 µM -0.680807756702907 0.241979084426265 no 2539 0.247996570658218 3660 3895976
SGTC_1875 nocodazole 6 µM -0.681339462871321 0.241814515967784 no 2540 0.247828359202783 3638 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1154 4088-0362 150 µM -0.682386338173177 0.241490675016283 no 2541 0.247497346074141 3666 6618304
SGTC_713 1488-1073 324 µM -0.68248662414863 0.241459664867938 no 2542 0.247465648899453 3623 3312542
SGTC_3073 9114972 49.47 µM -0.682486702412976 0.241459640668101 no 2543 0.247465624163455 3571 41905075
SGTC_425 3825-7017 13.1 µM -0.682815012389837 0.241358136714766 no 2544 0.247361871110853 3693 3397440
SGTC_992 3909-8734 162 µM -0.682848912080569 0.241347657231056 no 2545 0.247351159400014 3653 4288319
SGTC_1085 doxorubicin 7.67 µM -0.682896214322345 0.241333035001305 no 2546 0.247336213131258 3663 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_183 3914-0051 30.55 µM -0.685166065936348 0.240631936811248 no 2547 0.246619567276406 3647 1596232
SGTC_3083 9117465 49.47 µM -0.6852323145576 0.240611490998969 no 2548 0.246598667736286 3639 16420915
SGTC_2239 6685329 187.64 µM -0.686229761612776 0.24030377077906 no 2549 0.246284116496843 3654 805680
SGTC_705 1124-0212 310 µM -0.686453296391233 0.240234837973759 no 2550 0.246213652906405 3642 9554485
SGTC_1373 2887-0003 58.5 µM -0.687185317256551 0.240009175602641 no 2551 0.245982977837315 3645 776948
SGTC_3076 9116187 49.47 µM -0.689407956543678 0.239324704414788 no 2552 0.245283288897151 3611 27241210
SGTC_1801 st050089 28.441 µM -0.69007416204741 0.239119751504468 no 2553 0.2450737753755 3686 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_636 0kpi-0074 126 µM -0.690236167437572 0.239069926318114 no 2554 0.245022841206357 3651 616434
SGTC_776 4476-4378 112 µM -0.690405403660001 0.239017883331446 no 2555 0.244969639760301 3666 2892008
SGTC_223 busulfan 5 mM -0.691720061612527 0.238613814897044 no 2556 0.244556572937846 3640 2478 A DNA alkylator.
SGTC_1510 1123-0200 71.5 µM -0.692901339284601 0.238251060847379 no 2557 0.244185734574941 3720 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1935 st074532 41.6 µM -0.693106311784957 0.238188147397556 no 2558 0.24412141846519 3720 2829742
SGTC_695 3505-6186 243 µM -0.693286223627951 0.238132933468873 no 2559 0.244064973397999 3666 1819379
SGTC_559 1550-0661 158 µM -0.694646035416846 0.23771584183213 no 2560 0.243638577389863 3689 5830875
SGTC_1462 k081-0014 26.5 µM -0.695089224524684 0.237579990199842 no 2561 0.24349969360408 3468 3270634
SGTC_3154 9100113 49.47 µM -0.696053594605227 0.237284527212209 no 2562 0.243197633271007 3679 25237525
SGTC_2174 5790901 200 µM -0.696432516238329 0.237168488732759 no 2563 0.243079002764122 3687 786020
SGTC_3334 9142812 21.919 µM -0.697680212845702 0.236786622713787 no 2564 0.242688602683097 3696 45283678
SGTC_1485 3909-9022 254 µM -0.697855076152404 0.236733131638523 no 2565 0.242633915674007 3697 714516
SGTC_95 0471-0001 561.058 µM -0.699422872905957 0.236253836163581 no 2566 0.242143898824603 3606 4015405
SGTC_392 N-ethylmaleimide 8.33 µM -0.699622159862787 0.236192949901861 no 2567 0.242081649893096 3653 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_138 0850-0259 40.9225 µM -0.701135859815277 0.235730765693367 no 2568 0.241609116568909 3701 6813004
SGTC_3300 9124615 50.48 µM -0.701770173880717 0.235537236367355 no 2569 0.241411251071471 3699 24824903
SGTC_1847 st056231 15 µM -0.703126809357614 0.235123621042267 no 2570 0.240988363021913 3688 5393180
SGTC_2844 9010103 25.97 µM -0.703221778747838 0.235094681505612 no 2571 0.240958774424807 3682 2480525
SGTC_2310 7668677 200 µM -0.703276260446426 0.235078080464334 no 2572 0.240941801036659 3695 2197143
SGTC_2393 9031399 185.94 µM -0.703762243282193 0.234930025975829 no 2573 0.240790425295373 3705 1526623 YDL150W RPC53
SGTC_903 1134-0042 114 µM -0.703779226021428 0.234924853122642 no 2574 0.240785136384542 3681 701009
SGTC_1395 3486-0190 4.35 µM -0.704301243644059 0.234765880001624 no 2575 0.240622596001475 3695 6748079
SGTC_3029 9088683 49.47 µM -0.704657015699691 0.234657568715609 no 2576 0.240511853657828 3686 25236615
SGTC_3050 9093513 49.47 µM -0.705053753758765 0.234536818330678 no 2577 0.240388392429156 3685 25236664
SGTC_719 2810-4230 27.3 µM -0.705392517858762 0.234433739991656 no 2578 0.240282999492028 3662 721079
SGTC_1956 st077085 54 µM -0.705651036995424 0.234355095266454 no 2579 0.240202588515003 3709 24208685
SGTC_1548 st061468 90.8 µM -0.707749229527927 0.233717339537118 no 2580 0.239550499949028 3687 390799
SGTC_2762 leflunomide 42.06 µM -0.710201059746195 0.232973314465091 no 2581 0.23878973189766 3682 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1385 3091-4834 14.1 µM -0.712902499191012 0.232155069167764 no 2582 0.237953046285779 3665 4072814
SGTC_3003 9075612 71.4286 µM -0.713294779280976 0.232036383674817 no 2583 0.237831683689397 3696 6501993
SGTC_1464 k208-0027 110 µM -0.713669499260715 0.231923042598199 no 2584 0.237715785502246 3707 X1464
SGTC_1434 4073-0095 163 µM -0.713968414326115 0.231832652249063 no 2585 0.23762335544836 3691 24133745
SGTC_907 3448-6986 75.5 µM -0.714219734416488 0.231756669558924 no 2586 0.237545657901953 3722 590582
SGTC_2652 actinonin 100 µM -0.714940640529131 0.231538791894432 no 2587 0.237322861592262 3683 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2811 7967822 32.47 µM -0.715436036819545 0.231389135720236 no 2588 0.237169825726467 3721 2232244
SGTC_2138 5575593 77.673 µM -0.716769602903011 0.230986541780922 no 2589 0.236758135287508 3696 762213
SGTC_2160 5660466 132.927 µM -0.716927804869734 0.230938807712672 no 2590 0.236709322226469 3660 2859134
SGTC_1264 0783-0040 158 µM -0.718913699239578 0.230340075152679 no 2591 0.236097047586572 3641 2855798
SGTC_3186 9110464 49.47 µM -0.719573368883783 0.230141381816906 no 2592 0.235893856876193 3690 17018021
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.719948936320559 0.230028303275992 no 2593 0.235778218086308 3634 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3250 9135583 49.47 µM -0.720550267730206 0.22984731485847 no 2594 0.235593130726675 3729 7699353
SGTC_3159 9100096 49.47 µM -0.722263065928993 0.229332234944632 no 2595 0.23506637796035 3679 25236875
SGTC_3119 9125183 49.47 µM -0.723229011305226 0.229042037370802 no 2596 0.234769598941873 3594 22695334
SGTC_2831 7999036 19.48 µM -0.724179339209837 0.228756732883992 no 2597 0.234477820524374 3732 2988270
SGTC_251 melphalan 456.522 µM -0.726004661113919 0.228209300466153 no 2598 0.23391795656033 3784 460612 A DNA alkylator.
SGTC_1369 1866-0067 208 µM -0.72648562474808 0.228065177324023 no 2599 0.233770558455695 3719 3531355
SGTC_1471 k673-0312 37 µM -0.726599341630433 0.228031108979042 no 2600 0.233735715835771 3706 24099884
SGTC_2648 atorvastatin 78.68 µM -0.727089302949689 0.227884354619357 no 2601 0.233585625616462 3712 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_560 2332-1943 155 µM -0.729562961025831 0.227144250711656 no 2602 0.232828684695825 3706 21177716
SGTC_2719 novobiocin 32.65 µM -0.729571995130316 0.227141550246428 no 2603 0.232825922754207 3711 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_319 1348-1596 45.5 µM -0.729845649256766 0.227059758413642 no 2604 0.23274226877638 3781 5380505
SGTC_1019 4262-0212 3.4 µM -0.730698439835795 0.226804976396182 no 2605 0.232481684368997 3766 4677213
SGTC_1153 4055-0057 267 µM -0.732930015929267 0.226139028535523 no 2606 0.231800557408281 3744 882706
SGTC_1938 st074717 56.4 µM -0.7336720716337 0.225917829023565 no 2607 0.231574311938459 3616 17250979
SGTC_2364 9055074 200 µM -0.734466779421386 0.225681070172236 no 2608 0.231332149925223 3742 6470630
SGTC_1735 st034310 56.75 µM -0.734624888936054 0.225633983031798 no 2609 0.231283987912199 3834 871153
SGTC_1630 st005209 31.3 µM -0.735046576536214 0.225508425979817 no 2610 0.231155564277877 3705 3367314
SGTC_2679 rapamycin 1 nM -0.73519867603399 0.225463148216038 no 2611 0.231109252619702 3712 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1979 st071809 45.3 µM -0.735383778790102 0.225408052814777 no 2612 0.231052899027815 3822 4976333
SGTC_2372 9071633 200 µM -0.736647931844517 0.225031984472821 no 2613 0.230668239183931 3782 21321366
SGTC_1224 0823-0416 294 µM -0.738241174893801 0.224558523168554 no 2614 0.230183952983343 3776 3598164
SGTC_426 0988-0037 14.6 µM -0.739484165723049 0.224189538503647 no 2615 0.229806525622585 3724 5383008
SGTC_1208 2323-2347 50.3 µM -0.739860854805551 0.224077785507094 no 2616 0.229692214499005 3721 5412760
SGTC_1519 esterone 74 µM -0.741145471405898 0.223696914143712 no 2617 0.229302620738785 3746 698 A steroid.
SGTC_1448 4255-0083 152 µM -0.742224531021325 0.223377272271622 no 2618 0.228975654036181 3776 5399660
SGTC_3081 9117243 49.47 µM -0.742801098277366 0.223206586593232 no 2619 0.228801055228204 3756 45595589
SGTC_211 3455-0679 143.504 µM -0.743158003397433 0.223100966415557 no 2620 0.228693013001979 3751 748649
SGTC_1338 1486-1223 76 µM -0.743834743017299 0.222900774656562 no 2621 0.228488229236492 3770 3444526
SGTC_71 0417-1750 47.813 µM -0.744365055764584 0.222743970144236 no 2622 0.228327826773094 3701 6811472
SGTC_1841 st054148 70 µM -0.744775473081507 0.222622659847577 no 2623 0.228203732255671 3764 675442
SGTC_1488 4013-0813 75.9 µM -0.745639794337569 0.222367308786096 no 2624 0.22794251857608 3710 2910057
SGTC_1334 1486-0610 236 µM -0.746291928459507 0.222174755941901 no 2625 0.227745543111635 3813 3742339
SGTC_2267 7931562 200 µM -0.746492103988712 0.222115670064978 no 2626 0.227685099821472 3664 934880
SGTC_1289 0976-0073 69.1 µM -0.746761434107862 0.22203618595874 no 2627 0.22760378945354 3780 3391136
SGTC_2157 5649910 96.377 µM -0.746997121853535 0.221966643639335 no 2628 0.227532649084415 3720 2858091
SGTC_2457 5731572 11.68 µM -0.748759720257453 0.221446963608743 no 2629 0.227001020705941 3786 2865357
SGTC_545 4218-0007 221 µM -0.748917343642642 0.221400524239827 no 2630 0.226953513070584 3703 2840508
SGTC_593 1203-0218 61.7 µM -0.75200025359625 0.220493350353434 no 2631 0.226025453141305 3774 3666956
SGTC_3218 9131285 49.47 µM -0.752179596816544 0.220440642646859 no 2632 0.225971530888829 3737 17156417
SGTC_2273 7815444 169.05 µM -0.752578783172882 0.220323350522275 no 2633 0.225851535584972 3703 2824616
SGTC_3084 9116877 49.47 µM -0.753821725959471 0.219958368367366 no 2634 0.225478138214423 3668 27241325
SGTC_1944 st076371 56.9 µM -0.753981018919482 0.219911618107475 no 2635 0.225430309659268 3775 24208455
SGTC_23 0213-0011 39.996 µM -0.755466477275688 0.219475931428542 no 2636 0.224984569526504 3781 627608
SGTC_1079 idarubicin 2.36 µM -0.756138885451782 0.219278876471252 no 2637 0.224782964962839 3725 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1267 0828-0272 9.49 µM -0.756591021382349 0.219146431372646 no 2638 0.224647461071573 3798 745334
SGTC_2847 9005661 71.43 µM -0.757377917823649 0.218916033910756 no 2639 0.224411740905319 3722 2991449
SGTC_2320 7373003 200 µM -0.758302814669987 0.218645409175212 no 2640 0.224134861332888 3810 5415828
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.758352963650178 0.218630741094092 no 2641 0.224119854148404 3771 689007
SGTC_1315 1237-0019 3.69 µM -0.758622397728491 0.218551943986784 no 2642 0.224039235222256 3752 825140
SGTC_445 e6 berbamine 66 µM -0.758958035610011 0.218453808179714 no 2643 0.223938830121173 3853 6610268 A calcium/calmodulin antagonist.
SGTC_2742 clothiapine 36.27 µM -0.761393093539996 0.217742591756348 no 2644 0.223211155685958 3705 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1748 st037455 53.6035 µM -0.763780773573701 0.217046512016576 no 2645 0.222498948095836 3775 580690
SGTC_850 0388-0143 75.9 µM -0.764012411831093 0.216979051069101 no 2646 0.222429923052675 3739 67273
SGTC_633 0437-0093 97.7 µM -0.764742597825058 0.216766475372583 no 2647 0.222212417525924 3749 2831118
SGTC_2231 micatex 6.853 µM -0.765550330394134 0.216531464248856 no 2648 0.221971954118803 3802 20737 An antifungal of unknown mechanism.
SGTC_22 0964-0034 14.468 µM -0.76573649250787 0.216477320985415 no 2649 0.221916554405274 3786 138402
SGTC_2655 perillic acid 100 µM -0.765811509879369 0.216455505198443 no 2650 0.221894232326617 3804 5702197 An apoptosis inducer.
SGTC_2934 9036370 36.88 µM -0.768251648759773 0.215746582929179 no 2651 0.221168847087745 3802 6462800
SGTC_1300 1094-0077 113 µM -0.769017994777468 0.21552421798959 no 2652 0.220941314038297 3743 5532636
SGTC_1313 1220-0047 237 µM -0.769329014940614 0.215434009509846 no 2653 0.22084900839613 3782 3528706
SGTC_1234 0326-0494 15.5 µM -0.769397432807881 0.215414168488924 no 2654 0.220828706067517 3830 1547813
SGTC_756 0508-1999 28.3 µM -0.770454107254958 0.215107870022717 no 2655 0.220515284061806 3790 6753853
SGTC_1675 st018485 24.5 µM -0.771561161081366 0.214787239455827 no 2656 0.220187192534765 3857 3323024
SGTC_1756 st041558 35.5 µM -0.7719652853043 0.21467026415783 no 2657 0.220067494219129 3841 3955792
SGTC_870 0573-2213 57.6 µM -0.772631573056653 0.214477485488526 no 2658 0.21987022672118 3783 3916321
SGTC_1025 k007-0731 70 µM -0.772636481966907 0.214476065555115 no 2659 0.219868773719168 3767 6256118
SGTC_283 0987-0079 11.7 µM -0.774117919953509 0.214047800005189 no 2660 0.219430530614373 3821 411556
SGTC_2982 9019404 25.97 µM -0.775416580942313 0.213672782772757 no 2661 0.219046770253891 3736 22333232
SGTC_1904 st060225 78 µM -0.775461598736709 0.213659789751479 no 2662 0.219033474211607 3758 66595
SGTC_2260 7964312 200 µM -0.77844799751517 0.212798884822531 no 2663 0.218152476120752 3817 231951
SGTC_385 1494-0393 12.4 µM -0.779961772181721 0.212363275496616 no 2664 0.217706688392663 3803 3090647
SGTC_1001 4048-4355 44.4 µM -0.780441544663016 0.21222532323577 no 2665 0.217565511149684 3801 21824233
SGTC_1253 0550-0034 176 µM -0.780977103704005 0.21207139217525 no 2666 0.217407980652025 3815 5969915
SGTC_1611 st001856 99.4 µM -0.782484119008893 0.211638594407574 no 2667 0.216965057443838 3796 647478
SGTC_3353 9151644 39.2805 µM -0.783809596516641 0.211258359940177 no 2668 0.216575921016618 3873 4909158
SGTC_1387 3342-1166 1.8 µM -0.786366992830977 0.210525861932645 no 2669 0.215826257469352 3810 3418228
SGTC_3124 9127567 49.47 µM -0.786595606524542 0.210460454291984 no 2670 0.215759315996372 3743 17592030
SGTC_1691 st019933 84.6 µM -0.787494950444287 0.210203262812849 no 2671 0.215496091612722 3771 6176082
SGTC_317 4495-0002 170 µM -0.791497733444086 0.209060801107457 no 2672 0.214326799133253 3844 15991618
SGTC_1624 st003710 6.25 µM -0.791656874949851 0.209015455148669 no 2673 0.214280387138569 3815 24207033
SGTC_2334 9017922 200 µM -0.792200079559643 0.208860717457425 no 2674 0.214122011104441 3878 3163164
SGTC_2014 4013930 200 µM -0.79346926667573 0.208499438998729 no 2675 0.213752234171137 3781 64556
SGTC_2455 5377712 9.75 µM -0.79397916154582 0.208354399500151 no 2676 0.213603781385457 3827 2243908
SGTC_75 0159-0059 199.013 µM -0.794286124184195 0.208267112742111 no 2677 0.213514440057562 3852 5377270
SGTC_1805 st050013 60.3 µM -0.794515394136945 0.20820193246494 no 2678 0.213447725357115 3779 4037144
SGTC_2592 piperlongumine 83.33 µM -0.794549507082404 0.208192235357518 no 2679 0.213437799953386 3851 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1605 st000082 49.1 µM -0.794858817251867 0.208104321548491 no 2680 0.213347816241873 3824 1114022
SGTC_2438 5259590 200 µM -0.795209288064492 0.208004735321703 no 2681 0.213245884914863 3855 1201127
SGTC_1632 st005650 90 µM -0.79597597676633 0.207786978960816 no 2682 0.213022999346412 3874 2759605
SGTC_3075 9116269 49.47 µM -0.796237505460784 0.207712729900723 no 2683 0.212947000930118 3820 17015205 YNL244C SUI1
SGTC_2287 7945887 168.79 µM -0.796698469927017 0.207581898379229 no 2684 0.212813086395365 3857 1245853
SGTC_763 3453-1109 128 µM -0.79679361032757 0.207554901573368 no 2685 0.212785453330955 3813 1560353
SGTC_1428 4049-0204 61.7 µM -0.796982810420489 0.207501220786991 no 2686 0.21273050731341 3874 X1428
SGTC_1472 k841-0093 193 µM -0.798798294419356 0.206986539961111 no 2687 0.212203689845805 3925 X1472
SGTC_3236 9132701 49.47 µM -0.799477045268763 0.206794311591772 no 2688 0.212006925839155 3835 24282524
SGTC_3060 1327-0027 12.5 µM -0.799678630381143 0.206737241229099 no 2689 0.211948508614272 3765 16000455 YPR107C YTH1
SGTC_1116 jasmonic acid 1.58368 µM -0.800512786255684 0.206501184159651 no 2690 0.211706879208823 3857 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1714 st033236 13.627 µM -0.800528794642892 0.206496655521725 no 2691 0.211702243646632 3840 2916566
SGTC_1619 st003326 88.7 µM -0.801137696925576 0.206324445876694 no 2692 0.211525967405414 3772 2849032
SGTC_591 4299-0174 154 µM -0.802093784816539 0.206054217063038 no 2693 0.211249354963411 3832 5509088
SGTC_1683 st010134 710 nM -0.803049114296094 0.205784412350939 no 2694 0.210973173735475 3840 3818134
SGTC_162 k030-0015 37.8 µM -0.803129033203836 0.205761851111932 no 2695 0.210950079156724 3902 1809920 YMR134W ERG29
SGTC_1173 0443-0020 122 µM -0.8034641800427 0.205667254593937 no 2696 0.210853246189501 3837 5331295
SGTC_245 methotrexate 289.6 µM -0.803772679766676 0.205580202149318 no 2697 0.210764135337433 3837 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1417 3966-0327 90.4 µM -0.805213804790612 0.205173835378618 no 2698 0.21034815578677 3903 651118
SGTC_1465 k213-0056 144 µM -0.807626809849404 0.204494488669897 no 2699 0.209652724167289 3739 24048857 YMR208W ERG12
SGTC_2282 7944268 200 µM -0.807753089633538 0.204458973321921 no 2700 0.209616367416853 3832 2970414
SGTC_2955 9076254 12.21 µM -0.808310889260525 0.204302139821408 no 2701 0.209455817737913 3794 16459619
SGTC_3033 9090887 49.47 µM -0.808897319681199 0.204137333616643 no 2702 0.209287105388683 3885 19325384
SGTC_158 k038-0087 26.446 µM -0.810220411620536 0.203765792327115 no 2703 0.208906754081603 3781 X158
SGTC_2137 5261020 140 µM -0.81057313198875 0.203666811995997 no 2704 0.208805425797242 3821 763655
SGTC_2843 9000894 45.46 µM -0.811743136849891 0.203338690756724 no 2705 0.208469518281813 3769 2242070
SGTC_2488 5268135 45.7 µM -0.813766794924188 0.202771912487582 no 2706 0.207889280393275 3917 1270356 YLR208W SEC13
SGTC_1603 st002045 67.8 µM -0.814646270793724 0.202525886852716 no 2707 0.207637408286953 3855 5887985
SGTC_3214 9129694 49.47 µM -0.816502404683264 0.202007235828478 no 2708 0.207106424377707 3823 17158655
SGTC_3054 9094397 49.47 µM -0.819154315716399 0.201267605242416 no 2709 0.206349187924685 3882 2598354
SGTC_350 k064-0020 19.8 µM -0.819416199659706 0.201194652753259 no 2710 0.206274497736025 3820 2790705
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.819839637292037 0.201076730124216 no 2711 0.206153765793385 3828 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_52 0329-0193 875 nM -0.819986259063002 0.201035907270563 no 2712 0.206111970274523 3954 3739292
SGTC_3205 9113483 49.47 µM -0.820143140173781 0.200992233487921 no 2713 0.206067255826428 3934 17018033
SGTC_1171 0368-0077 21.4 µM -0.820449912252616 0.200906848341424 no 2714 0.20597983589302 3827 3239779
SGTC_2309 7664088 163.95 µM -0.820527079285895 0.200885373547049 no 2715 0.205957849294344 3856 704922
SGTC_2453 5731132 22.18 µM -0.820529872953043 0.200884596123954 no 2716 0.205957053342746 3892 1362040
SGTC_1413 3910-0535 34.4 µM -0.821093108188141 0.200727895614636 no 2717 0.20579661766891 3865 2876951
SGTC_48 0382-0018 55 µM -0.821592917735771 0.200588902547254 no 2718 0.205654310709279 3908 762596
SGTC_1882 5615643 20 µM -0.823910459126944 0.199945168282894 no 2719 0.204995218543575 3778 2253075
SGTC_1739 st037196 92.5 µM -0.8246380943943 0.199743312448607 no 2720 0.204788543580117 3922 612214
SGTC_3015 9080845 49.47 µM -0.826529663715748 0.199219139514 no 2721 0.204251849021264 3948 5296973
SGTC_237 nikkomycin 200 µM -0.827338796830381 0.198995173795038 no 2722 0.204022529850198 3877 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2916 7875993 68.79 µM -0.827350265372662 0.198992000426423 no 2723 0.204019280614453 3793 1299250
SGTC_2049 5262831 67.185 µM -0.827888285600247 0.198843163426332 no 2724 0.203866884859593 3915 763417
SGTC_2052 5265182 7.135 µM -0.828556248945609 0.198658472587011 no 2725 0.20367777678048 3890 1239884
SGTC_2989 9073649 71.4286 µM -0.828680063163791 0.19862424951443 no 2726 0.203642735050236 3795 21367202
SGTC_2912 7964298 10.93 µM -0.829071555957966 0.198516061702991 no 2727 0.203531958953176 3927 2975850
SGTC_3125 9127534 49.47 µM -0.829346305578148 0.198440156735584 no 2728 0.203454237761972 3722 1639235
SGTC_2983 9022671 12.99 µM -0.829389056476936 0.198428347536454 no 2729 0.203442145976795 3911 6405161
SGTC_1923 st058458 19.1 µM -0.830488543654007 0.198124778855538 no 2730 0.203131311235458 3871 3534982
SGTC_2371 9071574 200 µM -0.831910029226819 0.197732722213299 no 2731 0.202729865208581 3867 45596039
SGTC_3213 9129884 49.47 µM -0.831969166330178 0.197716421910174 no 2732 0.202713174398834 3884 17190742
SGTC_2837 9008476 45.46 µM -0.832570497393204 0.197550719652715 no 2733 0.202543501821851 3857 2992805
SGTC_2909 7941780 10.49 µM -0.834520228057723 0.197014031273139 no 2734 0.201993946742702 3826 1243215
SGTC_1139 k015-0024 46.9 µM -0.834681563691224 0.196969661138883 no 2735 0.201948512366029 3843 2766652
SGTC_1211 1056-0033 32.3 µM -0.835988980213668 0.196610321792976 no 2736 0.201580551244076 3878 6741922
SGTC_1515 3460-0031 42.1 µM -0.836167279048151 0.196561347707383 no 2737 0.201530401714452 3826 2876596
SGTC_1343 1487-0095 224 µM -0.838482182992207 0.195926174516775 no 2738 0.20087997507219 3855 4560101 YGL055W OLE1
SGTC_1727 st034309 9.9045 µM -0.839055331030735 0.195769104266573 no 2739 0.200719130422701 4010 870305
SGTC_3235 9132602 49.47 µM -0.839354799072349 0.195687065963932 no 2740 0.200635120358704 3899 4912240
SGTC_2023 5144124 124 µM -0.83965460776258 0.195604955250563 no 2741 0.200551035882367 3889 2830192
SGTC_844 0330-0132 15.3 µM -0.841935400983919 0.194980983540762 no 2742 0.199912056716785 3920 2828079
SGTC_1525 8-methoxypsoralen 92.5 µM -0.842180935896052 0.194913883157678 no 2743 0.199843341571388 3907 4114 Related to psoralen; DNA damaging agent.
SGTC_2601 securinine 100 µM -0.843106807848675 0.194660984933111 no 2744 0.199584355817986 3853 442872 A GABA receptor antagonist.
SGTC_2809 7964133 12.99 µM -0.843156931729114 0.19464729949454 no 2745 0.199570340885857 3917 1253665
SGTC_73 0327-0325 16.231 µM -0.843568892725865 0.194534843013859 no 2746 0.199455176604712 3830 53298
SGTC_812 4251-0442 148 µM -0.843615453667925 0.194522135366933 no 2747 0.19944216294405 3856 5723007
SGTC_3202 9113761 49.47 µM -0.844080065945639 0.194395358718351 no 2748 0.19931233303657 3944 4798415
SGTC_805 3852-0218 479 µM -0.84429927927711 0.194335560438575 no 2749 0.199251094373686 3827 6615355
SGTC_894 0960-0238 55.9 µM -0.844722480389759 0.194220148879289 no 2750 0.199132902463457 3839 6741907 YDL195W SEC31
SGTC_829 1635-0120 117 µM -0.845880921608502 0.193904442909986 no 2751 0.198809588274568 3912 285054
SGTC_209 4077-0173 175.592 µM -0.846710358866573 0.193678591499576 no 2752 0.198578291697181 3863 15993494
SGTC_2520 obtusaquinone 4.71 µM -0.846876600477407 0.193633344085608 no 2753 0.198531953153811 3903 5967872
SGTC_589 1227-0070 34.1 µM -0.847799526439699 0.193382260614704 no 2754 0.198274813438382 3940 2841384
SGTC_2297 7971671 152.32 µM -0.851982915503236 0.192246655968991 no 2755 0.197111787217308 3897 909016
SGTC_91 0417-1751 58.384 µM -0.852212225228905 0.192184526694222 no 2756 0.197048156270626 4000 6795624
SGTC_365 0121-0052 13.6 µM -0.854530553763437 0.191557087831567 no 2757 0.196405543842107 3958 3101739
SGTC_1219 1469-0211 33.1 µM -0.854572736853645 0.191545682919522 no 2758 0.196393862981646 3920 6822282
SGTC_874 0599-0792 117 µM -0.855530671158561 0.191286801168634 no 2759 0.196128716098454 3893 765305
SGTC_526 4469-0568 170 µM -0.855546492261319 0.191282527316613 no 2760 0.196124338794493 3862 2901964
SGTC_974 1326-0144 138 µM -0.856728592687 0.190963364823537 no 2761 0.195797448748916 3947 5411856
SGTC_3314 9135860 59.4275 µM -0.856803219918147 0.190943226730695 no 2762 0.195776822942571 3851 25252478
SGTC_1143 3454-2408 5.08 µM -0.857732627320503 0.190692536107692 no 2763 0.195520059682813 3839 X1143
SGTC_80 0159-0065 512.242 µM -0.859405579573956 0.190241797233012 no 2764 0.195058396241065 3810 1548079
SGTC_3327 9140648 26.9345 µM -0.861619170952277 0.189646402419965 no 2765 0.194448558957446 3946 8029710
SGTC_3128 9127691 49.47 µM -0.861870334254917 0.189578918926142 no 2766 0.194379437667101 3964 41316314
SGTC_783 0848-0141 92.7 µM -0.862728092247695 0.189348564708759 no 2767 0.194143491542742 3883 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_752 1896-0090 130 µM -0.863828055535894 0.189053417579787 no 2768 0.193841176693522 3901 772567
SGTC_128 0906-2981 13.371 µM -0.865696278149341 0.188552777415253 no 2769 0.193328370793374 3843 6740226
SGTC_2402 5553605 200 µM -0.865936925792502 0.188488348933188 no 2770 0.193262375985251 3991 6758546
SGTC_2793 7325131 81.82 µM -0.865945694208133 0.188486001625713 no 2771 0.193259971609222 3908 4176441
SGTC_594 1487-1584 10.8 µM -0.86613830683939 0.188434443714355 no 2772 0.193207160151306 3881 5013332
SGTC_268 camptothecin 39.6153 µM -0.866491671826971 0.188339878763631 no 2773 0.193110295746007 3897 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3277 9138724 49.47 µM -0.866516427137536 0.188333255026147 no 2774 0.19310351093209 3863 15943418
SGTC_2132 5317594 122.667 µM -0.868102614808185 0.187909141056929 no 2775 0.192669079873835 3901 794577
SGTC_2767 sibutramine 71.45 µM -0.868492158963198 0.187805075224841 no 2776 0.192562481472857 3910 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2048 5246248 200 µM -0.869776782713761 0.187462143226267 no 2777 0.192211200906292 3919 677046
SGTC_132 0417-1715 25.805 µM -0.870042736120271 0.187391195000546 no 2778 0.192138524913921 3871 6769098
SGTC_3080 9117754 49.47 µM -0.871259142259902 0.187066906701604 no 2779 0.191806336962959 3934 9550191
SGTC_2536 dehydroabietamide 32.04 µM -0.871378166325129 0.187035194087826 no 2780 0.1917738516178 4004 3983547
SGTC_204 PMA1.184 62.41 µM -0.87178156237687 0.186927738518622 no 2781 0.191663777429977 3961 2252213 YGL008C PMA1
SGTC_2162 5663267 200 µM -0.872330374363329 0.186781608789367 no 2782 0.191514085920156 3891 6456493
SGTC_2083 5306046 65.942 µM -0.874804380195762 0.186123744442434 no 2783 0.190840176752663 3961 539837
SGTC_3309 9129340 25.759 µM -0.875499278955192 0.185939222165859 no 2784 0.190651151188742 3975 17158987
SGTC_2254 7938975 95.19 µM -0.8813006037428 0.18440317765701 no 2785 0.189077569705119 4004 2969277
SGTC_1651 st011928 86.1 µM -0.881724964985999 0.184291128195865 no 2786 0.188962778582499 3962 720198
SGTC_2082 5219693 150 µM -0.884750169406854 0.183493573295788 no 2787 0.188145695298703 3930 2834649
SGTC_279 1273-0055 2.93 µM -0.8848172816516 0.183475904473293 no 2788 0.188127593580563 3950 2847562
SGTC_2177 5811945 192 µM -0.88585001662593 0.183204147274124 no 2789 0.187849176717207 3991 5343475
SGTC_1824 st053723 68.6 µM -0.888926365314125 0.182396115766513 no 2790 0.187021327391437 3994 675225
SGTC_554 4483-2211 187 µM -0.88942068120231 0.182266487052835 no 2791 0.186888517137157 3999 747107
SGTC_2546 rhodinyl acetate 100 µM -0.893825651358657 0.18111387756293 no 2792 0.185707591168272 3868 6708682
SGTC_2913 7966556 36.57 µM -0.89385045095728 0.181107401424654 no 2793 0.185700955789824 3815 2976516
SGTC_2583 asiatic acid 100 µM -0.89541571996743 0.180698942466028 no 2794 0.185282450199733 3967 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1077 5-fluorocytosine 377 nM -0.898696653306877 0.179844654675238 no 2795 0.184407130059651 3990 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_549 1661-1316 519 µM -0.898874316345874 0.179798467381169 no 2796 0.184359804879226 3972 2857282
SGTC_2628 lathosterol 100 µM -0.900268430949614 0.179436296257864 no 2797 0.183988708458382 4065 6710616
SGTC_1238 0333-0287 48.8 µM -0.903067165763852 0.178710610477674 no 2798 0.183245124458541 3959 7226
SGTC_1870 st057514 26.5 µM -0.903148826150147 0.178689464484341 no 2799 0.183223456633202 3950 5393161
SGTC_2645 abamectin 100 µM -0.903487669772467 0.178601737609913 no 2800 0.183133564696353 3922 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1459 k035-0031 35.7 µM -0.904902356731102 0.17823576715003 no 2801 0.182758559195223 3797 3877128 YMR208W ERG12
SGTC_360 0957-0399 1.01 µM -0.904947875768981 0.178223999519853 no 2802 0.182746500965552 3997 6752301 YPR165W RHO1
SGTC_1815 st051655 58.2 µM -0.906868086481512 0.177728030676181 no 2803 0.182238279652043 3930 5984156
SGTC_2353 9059630 146.67 µM -0.908863470820484 0.177213568859456 no 2804 0.18171109901031 4034 4779114
SGTC_2128 5255449 168.493 µM -0.909000183620568 0.177178355216538 no 2805 0.181675014441793 3974 736008
SGTC_2684 capsaicin 100 µM -0.910810192502103 0.176712560918967 no 2806 0.181197695576215 4011 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_118 0083-0097 135.343 µM -0.911464496103622 0.176544370733684 no 2807 0.181025342127982 4008 5207356
SGTC_1040 k898-0338 155 µM -0.911652675086059 0.176496017662925 no 2808 0.180975791968309 3979 20969351
SGTC_284 0988-0104 32.6 µM -0.915085818184303 0.17561533361081 no 2809 0.180073289729591 3967 4666532
SGTC_3100 9120536 49.47 µM -0.916020291206775 0.175376101692777 no 2810 0.179828126183968 3827 16421196
SGTC_2927 9011802 47.9 µM -0.916489384603199 0.175256088285409 no 2811 0.179705136326858 4014 43912568
SGTC_1411 3909-8223 150 µM -0.916804944125269 0.175175384473872 no 2812 0.179622430688526 3999 X1411
SGTC_1856 st057054 55.7 µM -0.917313137376735 0.17504546446817 no 2813 0.179489287571907 4028 1266018
SGTC_803 4488-1585 147 µM -0.918996318114855 0.174615594656948 no 2814 0.179048749013379 4000 747204
SGTC_2095 5432005 200 µM -0.920616742444403 0.174202386157461 no 2815 0.178625278981282 4007 783734
SGTC_932 2857-0803 154 µM -0.921913713602224 0.173872106394868 no 2816 0.178286792690214 4085 674898
SGTC_3034 9090421 49.47 µM -0.922338649889987 0.173763981053427 no 2817 0.178175979882061 3866 17173761
SGTC_271 rotenone 740 µM -0.922399163020686 0.173748586923976 no 2818 0.178160203095656 4032 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1213 1315-0166 115 µM -0.923308389031507 0.173517390453362 no 2819 0.177923258671652 4108 768401
SGTC_1312 1218-2183 165 µM -0.924384033858265 0.173244130228072 no 2820 0.177643202233383 4007 6744073
SGTC_1318 1280-3875 124 µM -0.924591817194372 0.173191375886811 no 2821 0.177589135537803 4016 373245
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.925681246846278 0.172914946846941 no 2822 0.177305828218784 4000 3256 An antibiotic and ribosome inhibitor.
SGTC_1975 st070967 30.8 µM -0.92580653792782 0.172883173849825 no 2823 0.177273264450366 3970 261391
SGTC_1878 temozolomide 1 mM -0.926100477266022 0.172808647363844 no 2824 0.177196882995407 3894 5394 DNA alkylating agent.
SGTC_1221 2958-7315 257 µM -0.92725728743224 0.172515544260221 no 2825 0.176896482603949 4026 4562705
SGTC_2594 a-mangostin 100 µM -0.928798094630318 0.172125639798527 no 2826 0.176496866051648 4051 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_537 1334-0398 209 µM -0.929374707904081 0.171979871346902 no 2827 0.176347465270675 4035 5846986
SGTC_2217 6934799 96.0675 µM -0.931592429309788 0.171419963749755 no 2828 0.175773598560275 3953 675606
SGTC_518 1021-0119 62.6 µM -0.932581477237166 0.171170635146018 no 2829 0.175518050317714 3985 1097762
SGTC_2378 9074213 121.43 µM -0.932709528999099 0.171138371604908 no 2830 0.175484981782856 3981 657714
SGTC_1032 k061-1018 98.7 µM -0.933419837726603 0.170959474956378 no 2831 0.175301620887713 4128 4005393
SGTC_1055 3448-0672 86 µM -0.935011162953717 0.170559122037719 no 2832 0.174891273299335 4064 748378
SGTC_1873 rapamycin 2 nM -0.935111215223942 0.170533970501018 no 2833 0.174865493672956 3982 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2411 st077133 39.94 µM -0.935511519959066 0.170433364068865 no 2834 0.174762374650011 4117 1403142 YNL221C POP1
SGTC_902 1120-0002 2.07 µM -0.936204297209201 0.170259341931236 no 2835 0.174584005554995 3992 3280475
SGTC_2491 paeonol 100 µM -0.936479982357918 0.170190122892826 no 2836 0.174513057171894 3876 11092 Increases levels of cortical cytochrome oxidase.
SGTC_522 1273-0010 11.6 µM -0.936925772995845 0.17007823192 no 2837 0.174398370393606 4131 5705015
SGTC_1222 0366-0074 1.18 µM -0.937694627823707 0.169885364434883 no 2838 0.174200682710129 4036 286520
SGTC_762 1165-0429 115 µM -0.938553435857969 0.169670098021806 no 2839 0.173980034740317 4024 5967793
SGTC_3198 9112019 49.47 µM -0.94060943311602 0.169155458680352 no 2840 0.173452523009784 4069 45595555
SGTC_1796 st049173 110.4 µM -0.942319411901294 0.168728195973967 no 2841 0.173014566301187 3958 94134
SGTC_508 roscovitine 141 µM -0.946404088262073 0.167710390853664 no 2842 0.171971260493627 4089 160355 A CDKinase inhibitor.
SGTC_1689 st020265 53.493 µM -0.946558954973589 0.167671879671305 no 2843 0.171931783713563 4017 5758320 YPR016C TIF6
SGTC_2156 5649887 115 µM -0.947269550861511 0.167495246629496 no 2844 0.171750721252545 4063 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2997 9067075 71.4286 µM -0.951933331304277 0.166338945981432 no 2845 0.170565397077808 4049 27209819
SGTC_378 3970-0959 8.33 µM -0.953953361827891 0.165839719377591 no 2846 0.170053625268232 4065 6615653
SGTC_2708 st078559 56 µM -0.954704654746709 0.165654293583661 no 2847 0.169863537643099 3984 17250902
SGTC_3143 9086658 49.47 µM -0.95541355110184 0.165479454619089 no 2848 0.169684301915904 4097 25236626
SGTC_1137 ixabepilone 100 µM -0.95546955021519 0.165465648342158 no 2849 0.169670148400297 3995 154225 A novel microtubule stabilizer.
SGTC_3231 9132313 49.47 µM -0.958201474227278 0.164793012290983 no 2850 0.168980586997001 4013 4905967
SGTC_1129 3453-1384 223 µM -0.9604151149568 0.164249285372916 no 2851 0.168423166951749 4162 1084452
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.961421485636964 0.164002480033544 no 2852 0.168170142729116 4056 229346 A bile salt which induces apoptosis.
SGTC_1112 tnp00069 1.16933 µM -0.962806392636182 0.163663234908322 no 2853 0.167822346029451 4056 145826
SGTC_474 dl-dihydrosphingosine 5 µM -0.962909660293146 0.163637956854516 no 2854 0.167796430615985 4057 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2861 9024595 19.48 µM -0.965178079082726 0.163083328434126 no 2855 0.167227812272433 3942 16482810
SGTC_2075 5212009 200 µM -0.965464772129376 0.163013319051111 no 2856 0.167156036222161 3950 780898
SGTC_1059 3448-6867 171 µM -0.967805505145229 0.162442451750406 no 2857 0.166570756950878 3970 3934407
SGTC_3345 9148410 3.559 µM -0.968588747561211 0.162251722329935 no 2858 0.16637520992844 4027 4903596
SGTC_1195 1502-0147 41.1 µM -0.969311855877226 0.162075765810778 no 2859 0.166194807846638 4029 817940
SGTC_686 1319-0111 510 µM -0.96961877873462 0.162001118762722 no 2860 0.166118274511222 4093 4562600
SGTC_2198 6589944 200 µM -0.969741644851189 0.161971242636153 no 2861 0.16608764337885 4051 5290268
SGTC_324 1315-0088 19.6 µM -0.969951757470449 0.16192015996616 no 2862 0.166035269717238 4012 6787421
SGTC_1927 st060202 13.8 µM -0.970987412865854 0.161668524364768 no 2863 0.165777273326897 3937 688887
SGTC_1333 1482-0047 286 µM -0.974919345678502 0.160715495655455 no 2864 0.16480013454879 4067 3811116
SGTC_1271 0832-2808 169 µM -0.975814779716856 0.160498972723681 no 2865 0.16457812962265 4102 3663794
SGTC_1989 st071868 50.2 µM -0.976095277153363 0.16043118547426 no 2866 0.164508625786755 4039 16414057
SGTC_1141 3253-0389 52.6 µM -0.976380667779388 0.160362234899493 no 2867 0.164437929006094 4055 5402031
SGTC_622 1348-1566 26.3 µM -0.979448650494427 0.159622231381013 no 2868 0.163679174381094 4095 7340407
SGTC_2755 lomerizine 42.69 µM -0.98018904336811 0.15944398241628 no 2869 0.163496405952286 4042 3949 A calcium channel blocker.
SGTC_1362 1611-0397 101 µM -0.981852471088933 0.159043989028274 no 2870 0.163086266904207 4035 27816
SGTC_610 4215-0184 155 µM -0.9843754527613 0.158438560315315 no 2871 0.162465471471807 4102 5605015
SGTC_2709 st078560 56 µM -0.98503631071771 0.158280227346937 no 2872 0.162303117728668 4070 17250903
SGTC_1736 st036774 51 µM -0.986676026051568 0.157887821424883 no 2873 0.161900743247532 4137 1272247
SGTC_2423 st077119 87.2 µM -0.987448467281205 0.157703187400879 no 2874 0.161711417047303 4001 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2357 9067248 200 µM -0.988295719318129 0.15750083476993 no 2875 0.161503920636049 4072 9150235
SGTC_50 0929-0078 56.389 µM -0.98833944539069 0.157490396127445 no 2876 0.161493216607235 3937 1377751
SGTC_2313 7726885 200 µM -0.991544503994101 0.156726496609108 no 2877 0.160709886221334 4126 726423
SGTC_3042 9091578 49.47 µM -0.99466569180842 0.155984934665426 no 2878 0.159949442952633 4062 25236497
SGTC_1649 st011737 51.3 µM -0.99555528782328 0.155774000054612 no 2879 0.159733134271511 4074 1761035
SGTC_2716 st080858 38.6235 µM -0.996740167791098 0.155493342060476 no 2880 0.159445323542259 4051 5296050
SGTC_2622 2-methoxyxanthone 59.94 µM -0.997675292969687 0.155272078213503 no 2881 0.159218418811977 4093 71034 A hepatoprotective.
SGTC_1375 2910-0797 186 µM -0.999034117011439 0.154950931779499 no 2882 0.15888908220885 4094 742508
SGTC_41 0478-0632 82.643 µM -0.999604941298112 0.154816153285979 no 2883 0.158750865454132 4002 3750424
SGTC_441 propafenone 146 µM -0.999702137060752 0.154793211913408 no 2884 0.158727338776777 4068 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2659 sanguinarine 24.21 µM -0.999840435406206 0.154760572861179 no 2885 0.158693866972216 4024 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_968 1309-0633 340 µM -1.00279657814536 0.154063996806755 no 2886 0.157979510098505 4146 3761976
SGTC_1321 1326-2144 215 µM -1.00334393993326 0.153935246163505 no 2887 0.157847471210908 4107 3513030
SGTC_585 0kpi-0023 191 µM -1.00602109039017 0.153306551853433 no 2888 0.15720271244728 4043 64601
SGTC_82 0054-0107 293.755 µM -1.00745589937899 0.152970306623027 no 2889 0.156857870123544 4041 3104697
SGTC_3069 9117009 49.47 µM -1.00751320007035 0.152956888456795 no 2890 0.156844108805759 4067 41904981
SGTC_2465 5809242 33.21 µM -1.00770465601087 0.152912060667307 no 2891 0.156798134563103 4132 2731748
SGTC_2650 prasterone 100 µM -1.00860966457543 0.152700278485699 no 2892 0.156580935245843 4078 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2345 9052315 157.45 µM -1.01037380683159 0.152288008897168 no 2893 0.156158116088153 4147 6469265
SGTC_1845 st056753 3.01 µM -1.0104364841445 0.152273375185996 no 2894 0.156143107812872 4056 5375839
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.01115432928593 0.152105841427151 no 2895 0.155971285366437 3922 88881 An O-methylated flavonoid and antioxidant.
SGTC_2894 9048625 32.47 µM -1.01241560966746 0.151811775023614 no 2896 0.155669688961547 4093 4092861
SGTC_2180 6301957 200 µM -1.01292092132639 0.151694068116255 no 2897 0.155548967207478 4128 845462
SGTC_621 3584-0052 32.1 µM -1.01672464275154 0.150809979298061 no 2898 0.154642219695539 4122 2273927
SGTC_632 0781-2353 4.65 µM -1.01746220202944 0.150638948226336 no 2899 0.154466802271403 4181 6811515 YHR007C ERG11
SGTC_910 3454-3003 490 µM -1.02103254810903 0.149812854834866 no 2900 0.153619509160281 4054 820824
SGTC_520 3584-0023 682 µM -1.02203122957202 0.149582325483948 no 2901 0.153383059900014 4115 1340790
SGTC_2871 9038510 12.99 µM -1.02308730768451 0.149338804699189 no 2902 0.153133283736297 4027 4945164
SGTC_2069 5228469 200 µM -1.02319931625594 0.149312992204651 no 2903 0.153106808078229 4128 2835210
SGTC_1546 5-methoxyflavanone 78.7 µM -1.02607776439912 0.148650672637877 no 2904 0.152427465180852 4099 147795
SGTC_2523 spermine 47.74 µM -1.02658786556668 0.148533505548667 no 2905 0.152307285132935 4140 1103 A DNA binding polyamine.
SGTC_2485 5633444 17.78 µM -1.02694179621933 0.148452246159115 no 2906 0.152223935895887 4128 5724239
SGTC_2978 9011784 42.97 µM -1.02822944530266 0.14815686403585 no 2907 0.151920955293366 4103 2994934
SGTC_2276 7947513 42.08 µM -1.03022710262852 0.147699387374061 no 2908 0.151451704909919 4073 2105100
SGTC_3009 9080819 71.4286 µM -1.03495472717343 0.146620502470053 no 2909 0.150345027285614 4141 17027216
SGTC_2238 6671620 73.2395 µM -1.03752029955605 0.146037235913067 no 2910 0.149746720118885 4061 729941
SGTC_1507 4075-3230 155 µM -1.0391019207098 0.145678442162178 no 2911 0.149378668888716 4038 659771
SGTC_888 0916-0002 6.97 µM -1.04015776870053 0.145439251186516 no 2912 0.149133304141083 4176 2802138 YIL048W NEO1
SGTC_415 dibenzyl ketone 100 µM -1.0405742525862 0.14534497394195 no 2913 0.149036593008544 4115 7593
SGTC_1425 4048-4433 7.33 µM -1.04087201390969 0.145277596501611 no 2914 0.148967475962651 4197 23734946
SGTC_152 4469-0003 551.229 µM -1.04107459131824 0.145231769293714 no 2915 0.148920465469445 4032 697280
SGTC_568 1193-0097 7.48 µM -1.04448569764518 0.144461567184498 no 2916 0.148130366474226 3975 3646150
SGTC_1753 st043925 64 µM -1.04594165457683 0.14413366270604 no 2917 0.147793985520351 4186 670181
SGTC_1332 1480-0653 17.5 µM -1.04719661765382 0.143851428225095 no 2918 0.147504452478376 4134 5749438
SGTC_101 0490-5701 117.494 µM -1.04759517797099 0.143761872200486 no 2919 0.147412580025683 3918 4661669
SGTC_1903 st060211 78.3 µM -1.04792015176794 0.143688878826092 no 2920 0.14733769844366 4170 688960
SGTC_2191 5911152 200 µM -1.04806724483176 0.143655848019477 no 2921 0.147303813135096 4146 2875902
SGTC_2685 mycophenolic acid 18.85 µM -1.04927075765511 0.143385783041229 no 2922 0.147026760350002 4112 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.04929854883395 0.143379550828992 no 2923 0.147020366855512 4144 1377
SGTC_876 0720-0963 56.8 µM -1.0524369084705 0.142676945541958 no 2924 0.146299571291728 4162 765861
SGTC_1058 3448-5425 97.3 µM -1.05669955870964 0.141726371767895 no 2925 0.145324363235031 4057 7279705
SGTC_448 monastrol 171 µM -1.05797014955086 0.141443860958507 no 2926 0.145034525776384 4062 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_269 exalamide 29 µM -1.05818301977149 0.141396567463847 no 2927 0.144986005531811 4075 3316 A derivative of salicylamide.
SGTC_3219 9131112 49.47 µM -1.05836928513748 0.141355193577183 no 2928 0.144943558388491 4061 17612988 YMR079W SEC14
SGTC_3025 9087895 49.47 µM -1.05958389395423 0.141085601821519 no 2929 0.144666972027622 4146 17173641
SGTC_305 1682-2595 20.8 µM -1.05965880163944 0.141068986907936 no 2930 0.144649925964792 4172 226033
SGTC_1276 0871-0068 94.2 µM -1.06029680527319 0.140927528169323 no 2931 0.144504796097823 4160 3414906
SGTC_2379 9035213 200 µM -1.06175313473595 0.140604990093605 no 2932 0.144173885260002 4159 646551
SGTC_804 1595-0054 20.9 µM -1.06242510287635 0.14045633616047 no 2933 0.144021371358337 4092 761523 Stimulates phospholipase C.
SGTC_351 caspofungin 25 nM -1.06329852066962 0.140263276728235 no 2934 0.143823297918792 4157 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.06372539921816 0.140168985502461 no 2935 0.143726557415835 4204 368090
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.06535297110404 0.139809873802996 no 2936 0.143358115091109 4160 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3161 9100388 49.47 µM -1.06831510366538 0.139157907240769 no 2937 0.142689198862506 4229 25236368
SGTC_2352 9027995 87.8 µM -1.06924792035275 0.138953023006512 no 2938 0.142478985460086 4123 2997347
SGTC_2328 6201408 200 µM -1.06958873541897 0.138878217500322 no 2939 0.142402233901786 4171 2890418
SGTC_2435 5706476 10.6 µM -1.07355090662221 0.138010572946075 no 2940 0.141512005500237 4151 5725375
SGTC_512 prima-1 270 µM -1.07592620336917 0.13749220172838 no 2941 0.140980130937504 4177 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1189 1431-2119 7.28 µM -1.0761521549037 0.13744296068113 no 2942 0.140929606767438 4164 3107275
SGTC_423 5-fluorouracil 457 µM -1.07672138635607 0.137318962888949 no 2943 0.140802377523433 4103 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1475 4092-1048 11.7 µM -1.08171763188666 0.136233890369229 no 2944 0.139689008026386 4176 2881759
SGTC_1123 mangostin 811.285 nM -1.08260695847652 0.136041365393979 no 2945 0.13949145868329 4187 5281650 An antioxidant.
SGTC_1715 st032160 10.2275 µM -1.08740919961092 0.135004975876937 no 2946 0.138428003639034 4115 5289825
SGTC_821 1114-0266 29.2 µM -1.08741111555338 0.135004563473865 no 2947 0.138427580459735 4188 3123235
SGTC_1118 chelidonine 707.474 nM -1.08755534521694 0.134973520786061 no 2948 0.138395726602093 4175 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2940 9060638 45.86 µM -1.08958958299785 0.134536211310457 no 2949 0.137946986911126 4172 4027022
SGTC_3118 9124250 49.47 µM -1.0897459349659 0.134502639903233 no 2950 0.137912537798949 4111 1504786
SGTC_99 0109-0120 622.8 µM -1.09477612749124 0.133425640634764 no 2951 0.136807363732312 4154 759414
SGTC_2729 fluphenazine 10.66 µM -1.09509454030937 0.133357666430076 no 2952 0.136737610170415 4111 3372 An atypical antipsychotic.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.09815655125824 0.132705209812892 no 2953 0.136068067495854 4138 279621
SGTC_63 0099-0242 26.702 µM -1.10170560059235 0.131951729686855 no 2954 0.135294840667591 4223 3898502 YLR359W ADE13
SGTC_668 1682-0499 62.6 µM -1.10246286640872 0.131791341262225 no 2955 0.135130246808522 4167 682214
SGTC_1521 st012942 49.4 µM -1.10406475017504 0.131452506620216 no 2956 0.134782525422473 4170 24207259
SGTC_1268 0828-0275 2.46 µM -1.1060944707974 0.131024039253507 no 2957 0.134342815839575 4254 745337
SGTC_469 w7 172 µM -1.10619756484364 0.131002302217546 no 2958 0.134320508324904 4274 45115570 A P450 inhibitor.
SGTC_1427 4048-4900 550 nM -1.10636009188132 0.130968038993975 no 2959 0.134285345851491 4186 24132586
SGTC_710 3448-4187 58 µM -1.10687346710988 0.13085985219541 no 2960 0.134174319437332 4178 3946412
SGTC_3260 9137109 49.47 µM -1.11035911259439 0.130126933491052 no 2961 0.133422154924071 4144 17478346
SGTC_825 1988-2224 89.6 µM -1.11839401406506 0.128448289508375 no 2962 0.131699374878682 4194 1180859
SGTC_2417 cerulenin 830 nM -1.12000197265804 0.12811416955145 no 2963 0.131356460730631 4238 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_296 1222-0039 74.9 µM -1.12078266858735 0.127952165543761 no 2964 0.131190191601362 4225 5984176
SGTC_464 bw-b 70c 158 µM -1.12234063712116 0.127629293488239 no 2965 0.130858817069465 4233 5353454
SGTC_3294 9122953 26.2835 µM -1.12336906235444 0.127416474125365 no 2966 0.130640391790568 4191 16459826
SGTC_2507 purpurin 79.67 µM -1.12650916179764 0.126768198675258 no 2967 0.12997503240697 4226 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1929 genistein trimethyl ether 50.5 µM -1.12659337790763 0.126750843887947 no 2968 0.129957220114306 4203 136420
SGTC_624 k048-0052 28 µM -1.12949163585362 0.126154594956126 no 2969 0.129345247985264 4204 6835531
SGTC_314 1671-0008 2.74 µM -1.12999559447622 0.126051117098661 no 2970 0.129239040422535 4101 3913060
SGTC_1008 4106-0037 6 µM -1.13002558681698 0.126044960635567 no 2971 0.129232721545298 4228 2905394
SGTC_689 0833-0039 98 µM -1.13010992643805 0.126027649547105 no 2972 0.12921495376618 4182 5374726
SGTC_2178 5812956 200 µM -1.13060746052411 0.12592556216003 no 2973 0.129110173007919 4188 5403383
SGTC_3087 9117406 49.47 µM -1.1306964120343 0.12590731656983 no 2974 0.129091446014932 4253 42546093
SGTC_571 k831-0106 44.2 µM -1.13215226741672 0.125608955856903 no 2975 0.128785211905839 4088 4783639
SGTC_1193 1488-0126 41.5 µM -1.13575826561682 0.124872073597483 no 2976 0.128028873991419 4198 1384710
SGTC_1277 0873-0036 22 µM -1.13594747015026 0.124833493403279 no 2977 0.127989274779542 4294 5965735
SGTC_655 k060-0012 42 µM -1.13663907244484 0.124692541481466 no 2978 0.127844599562888 4220 5994525
SGTC_625 k213-0058 121 µM -1.1367634811329 0.124667198192759 no 2979 0.127818586766436 4287 3655420
SGTC_2970 9090938 41.86 µM -1.1368155584722 0.12465659058914 no 2980 0.127807698930808 4303 17217104
SGTC_1587 estradiol valerate 56.1 µM -1.14083878031081 0.123839009107337 no 2981 0.126968509620377 4281 13791 A steroid.
SGTC_2441 5730946 39.09 µM -1.14172318813905 0.12365978802948 no 2982 0.126784549566675 4278 1774275
SGTC_2272 7805186 180 µM -1.14468973841907 0.123059957200912 no 2983 0.126168851861133 4241 2956062 YPR165W RHO1
SGTC_2545 solidagenone 89.61 µM -1.1450105139747 0.122995219395081 no 2984 0.126102401033681 4093 6708572 An anti ulcer agent
SGTC_2804 7954240 19.48 µM -1.14620279238767 0.122754807224442 no 2985 0.125855626383764 4263 828705
SGTC_2757 clomiphene 4.22 µM -1.14668505830566 0.122657656339772 no 2986 0.125755903987144 4266 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2437 5741531 144.16 µM -1.14694786894159 0.122604736711193 no 2987 0.125701583512321 4258 2262990
SGTC_2891 9063876 19.48 µM -1.14778878747378 0.122435516732581 no 2988 0.125527883590886 4248 6472478
SGTC_2845 9003024 42.97 µM -1.1497698362448 0.122037513791897 no 2989 0.125119340975216 4294 2990173
SGTC_3144 9087057 49.47 µM -1.1513005818162 0.121730601998403 no 2990 0.124804298944095 4141 17249618
SGTC_3059 1327-0034 3 µM -1.15145194655841 0.121700283126221 no 2991 0.124773176779548 4106 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2060 5238662 140 µM -1.15211702663747 0.121567128208479 no 2992 0.124636493670476 4225 790130
SGTC_2124 5246320 200 µM -1.15499762269944 0.120991589721646 no 2993 0.124045699993477 4266 579342
SGTC_1861 st057647 17.4 µM -1.1556438685215 0.120862734567461 no 2994 0.123913428256382 4333 688668
SGTC_2597 laccaic acid a 100 µM -1.16220345402108 0.119560280311498 no 2995 0.122576415992833 4245 5491415 A textile dye.
SGTC_2 0422-0095 29 µM -1.16336278403039 0.119331120205007 no 2996 0.122341171178588 4154 6790840
SGTC_1874 staurosporine 7.6 µM -1.16419505871612 0.119166799057793 no 2997 0.122172486135542 4259 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1117 retinoic acid 1.10837 µM -1.16671401413621 0.118670439582995 no 2998 0.121662940711923 4297 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1391 3442-0225 151 µM -1.16734991195719 0.118545367344332 no 2999 0.121534544926988 4228 5227075
SGTC_612 0302-0167 22.4 µM -1.16743521360976 0.118528596787023 no 3000 0.121517328696067 4257 235821
SGTC_2839 9003951 25.97 µM -1.16785424959117 0.118446237422169 no 3001 0.121432780549787 4307 2990634
SGTC_264 promethazine 12.5 mM -1.16831941504026 0.118354858930766 no 3002 0.121338973389109 4139 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2078 5212016 200 µM -1.17044624988916 0.117937692005239 no 3003 0.120910716339408 4142 1899708
SGTC_2890 9046729 58.44 µM -1.17152283285243 0.117726923201625 no 3004 0.120694342755665 4217 903329
SGTC_1783 st039459 87.517 µM -1.17169699408155 0.117692851728148 no 3005 0.120659365149008 4364 729761
SGTC_112 phenothiazine 287.218 µM -1.17452434812303 0.117140707479815 no 3006 0.120092532644045 4217 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1988 st071872 53.4 µM -1.17463976175364 0.117118207799391 no 3007 0.120069434265357 4293 16414116
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.17517412013851 0.117014075495724 no 3008 0.119962530925759 4279 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_129 0088-0017 176.636 µM -1.1758253103505 0.116887264478002 no 3009 0.119832345020793 4152 182446
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.18055858733289 0.11596844566516 no 3010 0.118889061642511 4177 6708630 An antioxidant.
SGTC_313 3474-0040 5.03 µM -1.18132770513273 0.115819630949573 no 3011 0.118736282668484 4275 1043375 YIL048W NEO1
SGTC_1122 capsaicin 818.572 nM -1.18272020617196 0.115550544471825 no 3012 0.118460026688079 4323 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2251 lansoprazole 556 µM -1.18300427732584 0.115495705240725 no 3013 0.118403726117187 4205 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_780 0109-0199 192 µM -1.18339135630512 0.115421010375708 no 3014 0.11832704069056 4343 610414
SGTC_895 0964-0006 13.7 µM -1.18651689767077 0.114819130338584 no 3015 0.117709116195367 4256 6738897
SGTC_3157 9099274 49.47 µM -1.18792170901791 0.114549336837572 no 3016 0.117432127979411 4304 17217662
SGTC_2302 7771753 200 µM -1.1948960961583 0.113216588920609 no 3017 0.116063814165524 4288 2203047
SGTC_486 niguldipine 82 µM -1.19901224413735 0.112435237341049 no 3018 0.115261592325603 4351 1236 A calcium channel blocker.
SGTC_859 0439-0102 54.6 µM -1.20064901446376 0.112125608909041 no 3019 0.114943689736471 4299 610143
SGTC_939 1165-0479 45.3 µM -1.2013009659981 0.112002448895243 no 3020 0.11481723793287 4280 1377347
SGTC_2910 7948405 25.97 µM -1.20143897937718 0.111976389229299 no 3021 0.114790481706926 4204 2971328
SGTC_1830 st055982 50.3 µM -1.20279738180264 0.111720127190189 no 3022 0.114527369116237 4254 455313 An antimicrobial agent.
SGTC_1574 spiramycin 23.7 µM -1.2030408608124 0.111674239349917 no 3023 0.114480254418873 4253 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_142 0335-0849 62.6745 µM -1.20412670890172 0.111469756609925 no 3024 0.114270304056098 4274 3889043 YPR107C YTH1
SGTC_978 1416-0512 87.4 µM -1.20456157931976 0.111387938674557 no 3025 0.114186298145656 4359 6814003
SGTC_186 3455-3465 67.277 µM -1.21092747722843 0.110195155157628 no 3026 0.112961600357266 4295 755278
SGTC_2514 salinomycin 42.74 µM -1.21478466457951 0.109476903139535 no 3027 0.112224115639924 4350 23682228 A polyether potassium ionophore.
SGTC_958 1222-0007 33 µM -1.21812744474258 0.108857164277897 no 3028 0.111587773008079 4366 7312461
SGTC_2605 digitonin 300 nM -1.21909377574853 0.108678481021156 no 3029 0.111404301019005 4314 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_666 0272-0154 136 µM -1.21947013020573 0.108608946817475 no 3030 0.111332903106386 4300 6870312
SGTC_2617 dihydrotanshinone i 20.83 µM -1.22181301275136 0.108176801934234 no 3031 0.110889173242239 4266 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_562 3772-2733 112 µM -1.22229255778104 0.108088502619467 no 3032 0.110798506304618 4293 2876874 YIL048W NEO1
SGTC_224 benfluorex 43.875 µM -1.22280790271172 0.107993669274794 no 3033 0.11070112995303 4322 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2045 5106652 78.05 µM -1.22325253792676 0.107911896030397 no 3034 0.110617163763228 4270 673349
SGTC_2869 9037858 32.47 µM -1.22422432541303 0.107733329012393 no 3035 0.110433807554467 4263 27187042
SGTC_3045 9092950 49.47 µM -1.22803411877561 0.107035328473388 no 3036 0.109717080158299 4292 44120432
SGTC_2848 9016370 25.97 µM -1.23304047604246 0.106123070397759 no 3037 0.108780331672883 4307 7894410
SGTC_303 1348-1668 34.2 µM -1.23465827209156 0.105829480013635 no 3038 0.108478855970667 4322 5380509
SGTC_2761 levamisole 97.89 µM -1.23576033780501 0.105629818527708 no 3039 0.108273830934587 4324 26879 An alkaline phosphatase inhibitor.
SGTC_2221 6807166 181.081 µM -1.23589021500751 0.105606306599143 no 3040 0.108249687347056 4276 674925
SGTC_484 loperamide 105 µM -1.2384500768336 0.105143661835211 no 3041 0.107774611158316 4386 3955 An opioid-receptor agonist.
SGTC_42 0133-0086 60.653 µM -1.24085141355195 0.104711002325629 no 3042 0.107330322075499 4197 162923 Model of phenazepam hydroxylation.
SGTC_2866 9034245 58.44 µM -1.24317148865546 0.104294210175678 no 3043 0.10690232335654 4321 6462273
SGTC_1100 amiodarone 5.07 µM -1.24432564137167 0.104087319706106 no 3044 0.10668986881881 4373 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2232 chlorophetanol 41.5365 µM -1.24624382221434 0.103744130013633 no 3045 0.106337447616501 4382 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1552 6-methylflavone 10.6 µM -1.24739625786607 0.103538338121485 no 3046 0.10612611900319 4275 689013
SGTC_2584 androsterone 48.74 µM -1.24968534051771 0.103130452703847 no 3047 0.105707257236659 4255 2754130 A steroid.
SGTC_2887 9044784 58.44 µM -1.25151446437499 0.102805365855403 no 3048 0.105373419902088 4286 6465546
SGTC_896 0964-0007 44.5 µM -1.25772134115608 0.101707780493732 no 3049 0.104246275695583 4305 6756758
SGTC_924 2046-0044 21.3 µM -1.25841759693984 0.101585193176528 no 3050 0.104120385610919 4316 3623589
SGTC_61 0978-8327 98.565 µM -1.2596112757391 0.101375276751498 no 3051 0.103904812940266 4238 6150059 YHR072W ERG7
SGTC_1179 1021-1431 9.29 µM -1.25991076616808 0.101322658972308 no 3052 0.103850777236204 4346 2840958
SGTC_2288 7946289 167.31 µM -1.26201765421639 0.100953059917111 no 3053 0.103471216933201 4372 1246052
SGTC_1098 clofazimine 15.1 µM -1.26330044598987 0.100728509184521 no 3054 0.10324061300924 4392 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2338 7999974 200 µM -1.26656412505789 0.100158849948886 no 3055 0.102655593453008 4334 315925
SGTC_2976 9009005 19.48 µM -1.26659495446701 0.100153480062548 no 3056 0.102650078745159 4350 2993148
SGTC_2765 myclobutanil 7.74 µM -1.26796394400815 0.09991524042304 no 3057 0.102405413458795 4355 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_387 norethindrone acetate 66.7 µM -1.26989541203444 0.0995798192600656 no 3058 0.102060943830144 4353 541197
SGTC_2769 toremifene 3.73 µM -1.27855140135519 0.0980867142993357 no 3059 0.100527536523642 4372 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3354 9151612 71.43 µM -1.27856739833801 0.0980839701869933 no 3060 0.100524718306325 4350 27261949
SGTC_320 4092-0846 5.34 µM -1.27913608563526 0.0979864544661368 no 3061 0.100424569083301 4301 1359356
SGTC_2935 9038016 29.96 µM -1.28195788527372 0.0975036367950851 no 3062 0.099928710129901 4317 6463195
SGTC_2829 7992743 58.44 µM -1.28214450853666 0.0974717666658969 no 3063 0.0998959790271586 4350 16462845
SGTC_2093 5331342 194.4 µM -1.28908173794477 0.0962924933089727 no 3064 0.0986848358373477 4406 33839
SGTC_2566 crystal violet carbinol 226 nM -1.28960798894499 0.0962034646394846 no 3065 0.0985934002581689 4356 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3225 9130819 49.47 µM -1.29358134707348 0.0955332229842707 no 3066 0.0979050344424857 4318 4547121
SGTC_1752 st044819 83.042 µM -1.29627909042169 0.0950801198301208 no 3067 0.0974396748416313 4316 441209 YML126C ERG13
SGTC_1558 st069300 45.6 µM -1.29789701671557 0.0948091392069451 no 3068 0.0971613626779636 4309 24208000
SGTC_1293 1000-1278 195 µM -1.30051607308824 0.094371689865269 no 3069 0.0967120755309227 4385 678847
SGTC_2730 imipramine 71.33 µM -1.30222737485814 0.0940866638633068 no 3070 0.0964193349000041 4344 3696 A tricyclic antidepressant.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.30471932514209 0.0936727534508917 no 3071 0.095994219275307 4297 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2569 tetrandrine 100 µM -1.30941140093868 0.0928970560684803 no 3072 0.0951975158075055 4371 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1080 nisoldipine 24.4 µM -1.31018499002167 0.0927696231268525 no 3073 0.0950666311235645 4381 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.31532288414838 0.0919265393152266 no 3074 0.0942007051844564 4375 140250 A respiratory chain inhibitor.
SGTC_394 menadione 8.33 µM -1.31581296600524 0.0918464185394708 no 3075 0.0941184131411945 4392 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2270 7924575 90.91 µM -1.31904920836856 0.0913186412589517 no 3076 0.0935763309553189 4352 1262135
SGTC_2816 7982706 58.44 µM -1.31939387773694 0.0912625641737429 no 3077 0.0935187337334198 4361 2981853
SGTC_355 1311-2252 105 µM -1.31960774746609 0.0912277807933191 no 3078 0.0934830074246267 4354 5338538
SGTC_1887 st057648 70.8 µM -1.31996172034201 0.091170232894187 no 3079 0.0934238994477846 4382 688672
SGTC_2252 omeprazole 400 µM -1.32335216702406 0.0906203869787539 no 3080 0.0928591454453618 4404 4594 A proton pump inhibitor.
SGTC_165 k038-0023 64.381 µM -1.32373304090796 0.0905587728491528 no 3081 0.0927958605129653 4374 46368543
SGTC_2199 6590217 200 µM -1.32499931669827 0.0903541504481686 no 3082 0.092585688973427 4297 703109
SGTC_2676 harmalol 100 µM -1.32768269666742 0.0899216677837849 no 3083 0.0921414760863309 4348 5459187 A monoamine oxidase inhibitor
SGTC_1200 1643-0193 18.4 µM -1.33054304292252 0.0894623593062403 no 3084 0.0916697072167862 4411 5403974
SGTC_3024 9090631 49.47 µM -1.3311651757557 0.089362689949307 no 3085 0.0915673336259694 4344 25236383
SGTC_1921 5740136 50 µM -1.33214137871814 0.0892064629979631 no 3086 0.0914068676728091 4330 1774243
SGTC_598 3937-0236 20.2 µM -1.33473005262845 0.0887931678749539 no 3087 0.0909823569352815 4452 1379313
SGTC_2109 5483026 200 µM -1.33581843682643 0.0886198281239803 no 3088 0.0908043126453206 4393 759335
SGTC_447 ml7 120 µM -1.33821682883892 0.0882387419946598 no 3089 0.0904128823801832 4446 4216 Selective myosin light chain kinase inhibitor.
SGTC_1392 3455-1037 33.9 µM -1.33888528806284 0.0881327469135959 no 3090 0.0903040098868237 4380 981132
SGTC_1930 st074634 34.3 µM -1.34133232955434 0.0877455383772257 no 3091 0.089906288838869 4309 684253 YOR116C RPO31
SGTC_1795 st049545 62.3 µM -1.34190653448538 0.0876548629521703 no 3092 0.0898131513773313 4343 5291882
SGTC_1633 st005664 67.9 µM -1.34218408219907 0.0876110591474621 no 3093 0.0897681581702702 4376 2063822
SGTC_534 k292-0788 63.4 µM -1.34345683509476 0.0874103968418063 no 3094 0.0895620470181136 4437 4146317
SGTC_1591 genipin 88.4 µM -1.34420415952792 0.0872927335839569 no 3095 0.0894411884880629 4421 442424 A DNA cross-linking agent.
SGTC_1048 3161-0300 24.5 µM -1.3442383829236 0.087287348079429 no 3096 0.0894356567307218 4401 2165101
SGTC_1720 st037298 9.481 µM -1.34641614641131 0.0869451580549869 no 3097 0.089084173286981 4388 597396
SGTC_2849 9019321 12.99 µM -1.34830628010943 0.0866489762230146 no 3098 0.0887799465362383 4411 16489627
SGTC_2167 5876490 200 µM -1.35461468964939 0.0856659136934584 no 3099 0.0877701754004225 4454 686534
SGTC_2397 5161689 200 µM -1.35530930532843 0.0855581815986954 no 3100 0.0876595157598864 4447 2259942
SGTC_1908 st060353 56.5 µM -1.35743972539128 0.0852283947873679 no 3101 0.0873207665077393 4438 4227716
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.35841123732736 0.0850783223290372 no 3102 0.0871666152600166 4445 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2899 9053889 58.44 µM -1.36362372402086 0.0842765136178818 no 3103 0.086343010747879 4390 6470052
SGTC_3312 9133330 71.43 µM -1.36522171989079 0.0840318419071031 no 3104 0.086091686879873 4422 17617324
SGTC_807 1315-0151 48 µM -1.36580151357836 0.0839432007469833 no 3105 0.0860006356038723 4430 4011080
SGTC_1811 st050069 61.5 µM -1.36595145798853 0.0839202880819138 no 3106 0.0859770999417739 4395 3877702
SGTC_3104 9120930 49.47 µM -1.36781300307669 0.0836362205797787 no 3107 0.0856853082420683 4436 17014836
SGTC_1389 3405-0187 19 µM -1.36782875970079 0.0836338192423788 no 3108 0.085682841605919 4397 799890
SGTC_433 pimozide 108 µM -1.3700554588627 0.0832949870273622 no 3109 0.085334795148393 4335 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2366 9070441 60.58 µM -1.371712266448 0.0830435444020413 no 3110 0.0850765141396735 4389 6837235
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.3783916367735 0.0820356487492271 no 3111 0.0840412020591999 4493 4213774
SGTC_1742 st038235 28.8875 µM -1.37916536608069 0.0819194936906422 no 3112 0.0839218868877773 4449 564103 YBR002C RER2
SGTC_2718 lomofungin 53.02 µM -1.37984388411017 0.0818177341319886 no 3113 0.0838173587777963 4402 5351222 A RNA synthesis inhibitor.
SGTC_3313 9133968 57.047 µM -1.38085723159369 0.0816659365446111 no 3114 0.0836614311236994 4421 1494643
SGTC_67 0335-0847 266 µM -1.38096444034481 0.0816498892991643 no 3115 0.0836449472594582 4481 4552207 YOR254C SEC63
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.38397202242855 0.0812006759376307 no 3116 0.0831835108076102 4424 6708760
SGTC_2425 5628681 7.85 µM -1.38442123740972 0.0811337414222408 no 3117 0.0831147548841357 4483 5714958
SGTC_2799 7812892 81.82 µM -1.39610489729486 0.0794074272517103 no 3118 0.0813414546510728 4451 20205235
SGTC_2959 9079155 11 µM -1.40508411966286 0.0780997095652194 no 3119 0.0799981328648264 4450 16189457
SGTC_358 0075-0058 9.45 µM -1.41044385074543 0.0773269521440157 no 3120 0.0792043324963205 4402 1069125
SGTC_2103 5378138 10 µM -1.410759126346 0.0772816777364127 no 3121 0.0791578251460747 4519 244142
SGTC_3139 9095020 49.47 µM -1.41327812690883 0.076920665544173 no 3122 0.0787869813539855 4308 25236292
SGTC_3039 9090270 49.47 µM -1.4136745942977 0.0768639625161351 no 3123 0.0787287340648726 4455 17173750
SGTC_3096 9117468 49.47 µM -1.41413778215107 0.0767977573382999 no 3124 0.0786607258283064 4386 41316311
SGTC_1722 st034304 3.6505 µM -1.41583957912703 0.0765548853618264 no 3125 0.0784112392495934 4400 4036148 YLR033W RSC58
SGTC_1260 0700-1617 7.75 µM -1.41658407479111 0.0764488185361379 no 3126 0.0783022836398975 4415 2853078
SGTC_3297 9117502 71.43 µM -1.41956098695387 0.0760258207995165 no 3127 0.0778677649997693 4470 7453720
SGTC_2551 apiole 73.87 µM -1.42269882917543 0.0755818875422983 no 3128 0.0774117400924274 4377 10659 A possible DNA adduct former.
SGTC_1034 k072-0165 12.7 µM -1.42633101944174 0.0750704847869845 no 3129 0.0768864073944958 4467 5835461
SGTC_1854 st056233 32.9 µM -1.42696346181234 0.074981708952923 no 3130 0.0767952133665184 4371 5393174
SGTC_325 2810-4341 181 µM -1.43658372828702 0.0736411674259929 no 3131 0.0754181549163239 4455 774970
SGTC_779 1360-0071 233 µM -1.43801890420196 0.0734427625179231 no 3132 0.075214345213149 4486 7566
SGTC_3343 9148379 18.9835 µM -1.44760835757389 0.072127551685151 no 3133 0.0738633062319538 4470 1955036
SGTC_2792 7535235 81.82 µM -1.46039956108385 0.0704014123095185 no 3134 0.072090146677913 4443 1281891
SGTC_1175 0741-0056 27.6 µM -1.46103295556468 0.0703167699466583 no 3135 0.0720031987932265 4537 765927
SGTC_1323 1348-1351 11.2 µM -1.46927096279647 0.0692230161218311 no 3136 0.0708796547076844 4458 6989654
SGTC_382 3229-0966 23.2 µM -1.47054277451799 0.0690553330372385 no 3137 0.0707074048370212 4518 5722370
SGTC_3287 9117173 37.0625 µM -1.47105308205151 0.0689881391804344 no 3138 0.0706383810104664 4503 2789709
SGTC_2806 7952793 58.44 µM -1.47524255724957 0.0684384010082472 no 3139 0.0700736718562538 4493 2972490
SGTC_376 3970-0862 59.1 µM -1.47789792386089 0.0680917206524952 no 3140 0.0697175510618571 4494 3135186
SGTC_1826 st055655 41.6 µM -1.47870800184748 0.0679862285120181 no 3141 0.0696091863827965 4488 676168
SGTC_1967 st070177 51.4 µM -1.48078687452955 0.0677160854545813 no 3142 0.0693316876167219 4495 5729214
SGTC_1145 3546-0597 10.2 µM -1.48098028779995 0.0676909942218081 no 3143 0.0693059131954858 4450 875334
SGTC_3261 9137475 49.47 µM -1.48668813232896 0.0669537524861472 no 3144 0.0685485992751213 4502 17027690
SGTC_1435 4092-0789 56.7 µM -1.48814764194882 0.0667662387666965 no 3145 0.0683559808094761 4482 2248285
SGTC_1405 3909-7894 12 µM -1.49310988993487 0.0661317414562254 no 3146 0.0677042120721558 4483 7104060
SGTC_1983 st071813 46.9 µM -1.49402271608334 0.0660155333549387 no 3147 0.0675848410109213 4554 11838595
SGTC_3021 9087658 49.47 µM -1.49594908574664 0.0657708145601013 no 3148 0.0673334617639535 4507 25237042
SGTC_696 1560-0013 611 µM -1.49962432889873 0.065305876644536 no 3149 0.0668558709970806 4527 1650269
SGTC_367 0335-0881 7.1 µM -1.50002781933707 0.0652549886632228 no 3150 0.0668035982503836 4429 23828853
SGTC_1374 2889-5571 141 µM -1.50125059074311 0.0651009613131136 no 3151 0.0666453796317841 4480 2853281
SGTC_1998 st075797 76.8 µM -1.5038108790295 0.0647793666210809 no 3152 0.066315034603458 4472 24208315
SGTC_315 k915-0449 187 µM -1.50539462939184 0.0645810520710997 no 3153 0.0661113245175971 4526 20970215 YNL149C PGA2
SGTC_2412 st077135 33.4 µM -1.50800993698476 0.0642546004356354 no 3154 0.06577599189596 4514 13258915
SGTC_1885 st057546 99.9 µM -1.51006059310944 0.0639995287664445 no 3155 0.065513981794884 4530 702008
SGTC_1365 1672-3266 55.4 µM -1.51041472093723 0.0639555602683497 no 3156 0.06546881733343 4522 6415873
SGTC_3269 9137823 49.47 µM -1.51049111225011 0.0639460786065571 no 3157 0.0654590777685378 4440 17682936
SGTC_2360 9040895 200 µM -1.51073729888153 0.0639155294497591 no 3158 0.0654276976745134 4521 4914414
SGTC_2077 5212015 200 µM -1.51111238488308 0.063869007065426 no 3159 0.0653799098986108 4419 780900
SGTC_810 3825-7150 143 µM -1.5172207520677 0.0631150799396322 no 3160 0.0646054792922457 4529 22330411 YGL099W LSG1
SGTC_390 dec-rvkr-cmk 16.7 µM -1.51965698180242 0.0628163280241578 no 3161 0.0642986043145287 4523 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2608 thymoquinone 42.66 µM -1.52019395109387 0.0627506285623031 no 3162 0.0642311186175886 4463 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1810 st050138 53 µM -1.52574135822764 0.062075020540734 no 3163 0.0635371450765219 4515 3444541
SGTC_1913 st060213 96.1 µM -1.53022870284832 0.0615326788229117 no 3164 0.0629800645133281 4493 688959
SGTC_564 3555-0129 330 µM -1.53059935046336 0.0614880482215289 no 3165 0.0629342211832923 4411 563260
SGTC_1364 1653-0028 37.6 µM -1.53069987424671 0.0614759482621396 no 3166 0.0629217924412223 4512 5718652
SGTC_2506 ethyl hematommate 54.16 µM -1.53452462989844 0.0610169458707322 no 3167 0.062450319367047 4528 3940691 An allergen.
SGTC_1187 1391-0724 117 µM -1.53476132360713 0.0609886289228946 no 3168 0.0624212331659156 4562 6997986
SGTC_362 0310-0100 9.03 µM -1.53523041608726 0.0609325392096163 no 3169 0.0623636197616371 4540 790235
SGTC_33 0986-0033 35.816 µM -1.53566686966191 0.060880388378179 no 3170 0.0623100522787432 4489 2848082
SGTC_921 1561-0023 372 µM -1.53670629685435 0.0607563301453043 no 3171 0.0621826242171431 4487 24050882
SGTC_1946 st076057 65.1 µM -1.53734378865119 0.0606803417706798 no 3172 0.0621045718552264 4506 953009
SGTC_945 3381-0768 11.3 µM -1.54567591102945 0.0596939825467916 no 3173 0.0610914288854958 4518 1126236 YIL048W NEO1
SGTC_773 4358-1457 44.6 µM -1.54577524113291 0.0596823000504821 no 3174 0.0610794292488373 4506 1186886
SGTC_774 k060-0086 136 µM -1.54735208480021 0.0594970828324422 no 3175 0.0608891842939105 4516 5911235
SGTC_909 3448-9333 149 µM -1.5492373596958 0.059276228739969 no 3176 0.060662335810038 4445 3344074
SGTC_404 fumagillin 50 µM -1.55258188928102 0.0588860098241473 no 3177 0.0602615275651759 4522 12015870 A methionine aminopeptidase binder.
SGTC_1239 0337-0584 35.4 µM -1.56076012782102 0.0579403139196138 no 3178 0.0592901791862386 4568 914301 YML130C ERO1
SGTC_39 0986-0283 58.349 µM -1.565371449957 0.0574123678625942 no 3179 0.0587479193400694 4548 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3093 9117344 49.47 µM -1.56629372950423 0.057307232502695 no 3180 0.0586399341549506 4546 24824913
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.56830538180682 0.0570784396024254 no 3181 0.0584049402756577 4531 75037 A free radical scavenger.
SGTC_2751 anetholtrithion 17.25 µM -1.59682369091511 0.0539117192827744 no 3182 0.0551525067371603 4498 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3342 9147791 14.508 µM -1.60048001287673 0.0535159762157069 no 3183 0.0547460687134498 4504 1838168
SGTC_1799 st045822 46.1415 µM -1.60330340754683 0.0532119629849445 no 3184 0.0544338422761884 4529 3674992
SGTC_1135 dihydrocapsaicin 536.708 nM -1.6047711042564 0.0530544682691362 no 3185 0.0542720936507097 4457 107982 A Capsaicinoid.
SGTC_1647 st011722 22.4 µM -1.61012985720547 0.0524825709327341 no 3186 0.0536847550969293 4538 2854783
SGTC_3295 9122362 53.5725 µM -1.61779597018155 0.0516729475190167 no 3187 0.0528532875765364 4538 4730473
SGTC_1304 1165-0502 251 µM -1.61828297768803 0.0516218516166308 no 3188 0.0528008137160638 4548 767425
SGTC_3215 9129942 49.47 µM -1.6219805089259 0.0512352227888314 no 3189 0.0524037607837853 4517 17682944
SGTC_2009 4012297 12.05 µM -1.62309197036778 0.0511194553192599 no 3190 0.0522848729269823 4511 45595307
SGTC_2445 5742597 35.57 µM -1.62719814098101 0.0506935693470876 no 3191 0.051847511226514 4559 1774255
SGTC_931 2812-0076 566 µM -1.63214957885755 0.0501837769695083 no 3192 0.051323989774821 4495 3450959
SGTC_1512 0259-0544 12.2 µM -1.63491412044302 0.0499009268745685 no 3193 0.0510335259751882 4530 18476
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.63516983861787 0.0498748278123023 no 3194 0.0510067245170943 4534 688761
SGTC_3232 9132874 49.47 µM -1.64201741555117 0.0491799921523674 no 3195 0.0502931974600782 4536 3784940
SGTC_104 0074-0074 590.992 µM -1.64476568232539 0.0489033039522541 no 3196 0.0500090708813797 4439 3943124
SGTC_2020 4017018 200 µM -1.6487235535413 0.0485070230284215 no 3197 0.0496021412585221 4586 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2995 9067767 71.4286 µM -1.65283346094882 0.0480982414121369 no 3198 0.0491823810485615 4548 11673567
SGTC_349 k015-0014 24 µM -1.65919083853834 0.0474713558566243 no 3199 0.0485386715574769 4571 2196908
SGTC_1909 st060837 51.5 µM -1.66234468147617 0.047162801339015 no 3200 0.0482218418631543 4517 678937
SGTC_359 0081-0058 15.9 µM -1.66452371851421 0.0469505570904784 no 3201 0.0480039075982785 4555 3494159
SGTC_111 0083-0039 52.457 µM -1.66783201198412 0.0466297851313947 no 3202 0.0476745395857052 4560 759313
SGTC_2692 st077426 47.7 µM -1.66945609325353 0.046472959109254 no 3203 0.0475135124753767 4560 25238571
SGTC_3089 9117425 49.47 µM -1.67005396041241 0.0464153340339301 no 3204 0.0474543439842603 4547 9401657
SGTC_3136 9095672 49.47 µM -1.67292012654477 0.0461398764523418 no 3205 0.0471715105406545 4446 17217380
SGTC_1798 st045719 60.953 µM -1.67333462858564 0.046100148949174 no 3206 0.0471307195284854 4558 3980186
SGTC_2634 4'-methoxyflavone 100 µM -1.677623800294 0.0456906690470843 no 3207 0.0467102817612464 4573 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2953 9074162 66.49 µM -1.6786007963075 0.0455978069425541 no 3208 0.0466149356384987 4557 16451992
SGTC_1654 st012436 41.8 µM -1.67865029607631 0.0455931061004323 no 3209 0.0466101090610973 4580 4323132
SGTC_1487 3970-0795 2.82 µM -1.68269535555356 0.045210274157661 no 3210 0.046217040650158 4635 3765103
SGTC_369 0957-0393 4.5 µM -1.68270701381923 0.045209174547142 no 3211 0.0462159116468036 4572 6997992
SGTC_2135 5326629 150.42 µM -1.68619653487625 0.0448810079683925 no 3212 0.0458789755523066 4540 5020077
SGTC_1231 0242-0792 125 µM -1.69094760450258 0.0444372870382678 no 3213 0.045423405067262 4571 3707635
SGTC_2065 5221596 34.26 µM -1.69861671065716 0.0437285035044373 no 3214 0.0446957128910221 4559 788581
SGTC_2651 TUB2.036 5 µM -1.70551209631638 0.0430990415096789 no 3215 0.0440494791089965 4472 15992207 YFL037W TUB2
SGTC_2271 7849410 118.62 µM -1.72466805755707 0.0413886847357622 no 3216 0.0422936553513469 4533 972430
SGTC_1597 7-benzyloxygramine 47.5 µM -1.72991924310315 0.0409295592108929 no 3217 0.0418223523430181 4502 260807
SGTC_438 sphingosine 6.67 µM -1.73647131480575 0.0403624962370851 no 3218 0.0412402660637291 4546 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1249 0481-0015 10.2 µM -1.74369179966695 0.0397449907776428 no 3219 0.0406064230293305 4551 4227577
SGTC_1410 3909-8106 77.9 µM -1.74569375731 0.0395751474263887 no 3220 0.0404320902208438 4640 1039210
SGTC_252 miconazole 1.30953 nM -1.74635287591117 0.0395193580420051 no 3221 0.0403748265570669 4529 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2120 5538279 151.968 µM -1.75261306540347 0.0389926635100061 no 3222 0.0398342235299484 4611 2058197
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.7546905527333 0.0388191445907377 no 3223 0.0396561264251307 4626 23665772 A membrane-active detergent.
SGTC_2522 biochanin a 4.94 µM -1.75479637917597 0.038810322462519 no 3224 0.039647071583776 4602 5280373 A possible chelator.
SGTC_3178 9107506 49.47 µM -1.75805279343967 0.0385396516677969 no 3225 0.039369263459693 4593 8897194
SGTC_3187 9109394 49.47 µM -1.76083304479711 0.0383097784123532 no 3226 0.0391333325355499 4613 17098090
SGTC_1204 4049-0315 18.3 µM -1.76285758007181 0.0381430927092088 no 3227 0.0389622565474092 4608 588402
SGTC_105 0111-0055 734.78 µM -1.76344975512298 0.0380944492304557 no 3228 0.0389123322225783 4614 5179370
SGTC_937 3122-0005 46.7 µM -1.76573829658093 0.0379069352814756 no 3229 0.0387198823214942 4596 759535
SGTC_3194 9111903 49.47 µM -1.76627112790769 0.0378633854733145 no 3230 0.038675186497067 4595 17087251
SGTC_1627 st003713 25.6 µM -1.76865018676874 0.0376694361363072 no 3231 0.0384761349877569 4612 16195070 YER133W GLC7
SGTC_2941 9056145 11.23 µM -1.77402043271855 0.0372346154255939 no 3232 0.0380298853002377 4578 2119517
SGTC_2919 7978188 46.38 µM -1.77524883740295 0.0371357318558303 no 3233 0.0379284045467253 4602 2980291
SGTC_1554 st069299 38.7 µM -1.77723080016827 0.0369766412418424 no 3234 0.0377651369094285 4580 24207999
SGTC_2898 9056270 58.44 µM -1.78237664628675 0.0365661879952232 no 3235 0.0373439156295059 4640 19154699
SGTC_2486 5283202 22.39 µM -1.78433636256849 0.0364108565688569 no 3236 0.0371845124692211 4621 1377751
SGTC_2780 5215298 71.43 µM -1.78458746643579 0.0363909926104553 no 3237 0.0371641279453764 4620 2834131
SGTC_1101 ebselen 5.29 µM -1.79087461474808 0.035896522285934 no 3238 0.036656709080862 4641 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2059 5238311 157 µM -1.79413794125223 0.0356420468461313 no 3239 0.0363955772380638 4580 703021
SGTC_153 4077-0274 519.67 µM -1.79549255402675 0.0355368488202803 no 3240 0.0362876290181118 4619 3121976
SGTC_1641 st009299 47.1 µM -1.80293300739532 0.034963559748944 no 3241 0.0356993682253523 4572 4046054
SGTC_3107 9121808 49.47 µM -1.80959235957107 0.0344569129405267 no 3242 0.0351795128260775 4580 662681
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.81060631627402 0.0343803023866512 no 3243 0.0351009068882297 4654 688788
SGTC_3280 9140961 49.47 µM -1.81402729159598 0.0341228591813833 no 3244 0.0348367620841374 4650 4901226
SGTC_1207 2099-0101 141 µM -1.81859397280791 0.0337816688205297 no 3245 0.0344866990217918 4630 5837381
SGTC_2200 6600604 21.907 µM -1.81947387691189 0.0337162521513567 no 3246 0.0344195823644181 4657 2904777
SGTC_1924 st058459 75.1 µM -1.82291674400942 0.0334612925286652 no 3247 0.0341580007610986 4610 688683
SGTC_716 1683-5115 658 µM -1.82298920467339 0.0334559435965807 no 3248 0.034152512966059 4625 723597
SGTC_2034 5197015 53.07 µM -1.83152304226591 0.0328308950992899 no 3249 0.033511255828942 4634 780676
SGTC_1368 1852-0141 284 µM -1.83636073969642 0.032480861237332 no 3250 0.0331521610037468 4596 2838987
SGTC_2245 6637752 200 µM -1.83729137065849 0.0324138793456522 no 3251 0.0330834465625418 4646 681890
SGTC_2746 daunorubicin 9.88 µM -1.84076290959326 0.0321650211020267 no 3252 0.0328281551917159 4671 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2962 9082311 13.18 µM -1.84408908899476 0.0319280645972857 no 3253 0.0325850788915283 4621 16459453
SGTC_1468 k284-1086 134 µM -1.84458819483089 0.0318926330862185 no 3254 0.03254873278279 4636 15996457
SGTC_234 nsc-17383 10.7 µM -1.84551480990228 0.0318269388217411 no 3255 0.0324813430773663 4649 408974
SGTC_3341 9147222 25.867 µM -1.85059184594076 0.0314689733075476 no 3256 0.0321141468360106 4638 1939759
SGTC_3090 9117696 49.47 µM -1.85725741604293 0.0310040650956898 no 3257 0.0316372698935746 4614 7923821
SGTC_1497 4476-2978 41.3 µM -1.8600094308592 0.030813783168393 no 3258 0.0314420958439133 4682 1528379
SGTC_3105 9121040 49.47 µM -1.86151472391374 0.0307101127105587 no 3259 0.0313357616588793 4632 41448907
SGTC_741 4582-0002 126 µM -1.87008440385197 0.0301254018015346 no 3260 0.0307360489529911 4658 2912688
SGTC_2458 5808907 16.39 µM -1.87144871388168 0.0300331718173436 no 3261 0.0306414560919184 4723 2731747
SGTC_1793 st048256 72.231 µM -1.87998991909471 0.0294610768397879 no 3262 0.0300547259165452 4651 672022
SGTC_972 1319-0219 195 µM -1.88046846249387 0.0294292932118774 no 3263 0.0300221303106385 4641 23903702
SGTC_2101 5377231 179.231 µM -1.88058062536562 0.029421847760726 no 3264 0.0300144946671615 4676 2844213
SGTC_1278 0874-0585 172 µM -1.8829414989764 0.0292654938500812 no 3265 0.0298541482290071 4680 766306
SGTC_1266 0828-0227 32.9 µM -1.89267423566582 0.0286281915597834 no 3266 0.0292006023650515 4629 3913820
SGTC_2415 st077333 57.7 µM -1.89348352791319 0.0285757226978735 no 3267 0.0291467983653662 4625 2766255
SGTC_412 gemfibrozil 100 µM -1.8948690183087 0.028486082860851 no 3268 0.0290548783106214 4625 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1808 st050063 61.5 µM -1.89886777073326 0.0282286786553314 no 3269 0.0287909319132396 4627 4011993
SGTC_2002 4023503 131 µM -1.90175585203974 0.0280439762019775 no 3270 0.0286015401792094 4640 4736863 YCR052W RSC6
SGTC_725 1497-0963 19 µM -1.9038809501494 0.0279087127028896 no 3271 0.0284628453181735 4694 3549977
SGTC_1210 3013-0140 750 nM -1.91389962731587 0.0272783189484443 no 3272 0.0278164910195077 4684 905973
SGTC_307 1501-1223 22.3 µM -1.91403304448263 0.0272700049007672 no 3273 0.0278079668234655 4671 2830329
SGTC_2179 6298986 200 µM -1.91559811883973 0.0271726331867696 no 3274 0.0277081346014171 4630 738374
SGTC_417 st075190 100 µM -1.92348570585516 0.0266863083757612 no 3275 0.0272095399777109 4640 222757
SGTC_2479 5617353 43.85 µM -1.92459662284833 0.0266184002305493 no 3276 0.0271399211197816 4652 2731746
SGTC_3160 9100216 49.47 µM -1.93971920079322 0.0257082562892296 no 3277 0.0262069123998021 4668 17191039
SGTC_1560 lithocholic acid 53.1 µM -1.94044062730405 0.0256654967338212 no 3278 0.0261630815892553 4621 9903 A bile acid which acts as a detergent.
SGTC_3017 9080681 49.47 µM -1.95324717947485 0.0249162966738336 no 3279 0.0253951565302117 4691 16451914
SGTC_2107 5363541 170.161 µM -1.95335154626057 0.0249102672336468 no 3280 0.0253889767435636 4622 244052
SGTC_1000 4048-0884 8.67 µM -1.96161711731321 0.0244366220447046 no 3281 0.0249035389388464 4672 13040088
SGTC_1755 st041960 45.185 µM -1.96371906097613 0.0243173865743133 no 3282 0.0247813404442872 4683 2257073
SGTC_2475 5812728 15.03 µM -1.96713958032565 0.0241243976753112 no 3283 0.024583560636432 4643 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2537 larixol 68.93 µM -1.9701558378537 0.0239552866980295 no 3284 0.024410256551417 4652 6708759
SGTC_2428 5615643 7.78 µM -1.98065411128977 0.023374433884435 no 3285 0.0238150381046636 4680 2253075
SGTC_1971 st069429 63.5 µM -1.98090691269664 0.0233605942221577 no 3286 0.0238008568643908 4676 1246522 YGL099W LSG1
SGTC_2975 9084847 53.72 µM -1.98460791605681 0.0231587702681325 no 3287 0.0235940554673887 4648 27211724
SGTC_587 k089-0003 57 µM -1.98594977551104 0.0230859592245293 no 3288 0.0235194504902124 4633 9659696
SGTC_3226 9131256 49.47 µM -1.99958899087023 0.0223567543524001 no 3289 0.0227723318508289 4715 17178073
SGTC_2292 7671323 168.05 µM -2.00328500683417 0.0221625302762618 no 3290 0.0225733529288431 4677 937504
SGTC_2682 pyrogallin 40.03 µM -2.00347130933132 0.0221527779731263 no 3291 0.022563362064293 4710 822798 An ATP competetive kinase inhibitor.
SGTC_2669 eugenol 100 µM -2.00622700048263 0.0220089493495925 no 3292 0.0224160171908402 4716 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_31 0508-1974 57.237 µM -2.00712858164687 0.0219620643372871 no 3293 0.0223679868091885 4653 6810525
SGTC_1081 sertraline 6 µM -2.01690467894594 0.0214590694124314 no 3294 0.0218527308532042 4676 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1606 st000094 49.2 µM -2.01953330144895 0.0213254960113528 no 3295 0.0217159098356843 4707 1242210
SGTC_3108 9121785 49.47 µM -2.02715437476705 0.0209421991493242 no 3296 0.0213233137526935 4582 17140271
SGTC_603 3794-0023 45.9 µM -2.03072912979073 0.0207644279191734 no 3297 0.0211412398365827 4716 3802260
SGTC_2954 9074818 52.69 µM -2.04023633173997 0.0202978456771733 no 3298 0.0206633963614367 4685 16648742
SGTC_2791 5663188 71.43 µM -2.04784753396685 0.019930746903953 no 3299 0.0202874705384667 4665 54690634
SGTC_1347 1493-0251 600 nM -2.05056395950964 0.0198011012015515 no 3300 0.020154714584437 4719 3986378
SGTC_2303 7774051 200 µM -2.05327111369886 0.0196726108081827 no 3301 0.0200231453900813 4678 2953184
SGTC_2828 7998861 71.43 µM -2.05447750305005 0.0196155800467918 no 3302 0.0199647492966126 4705 2988188
SGTC_1636 st007707 68.9 µM -2.06354697035165 0.0191913093485206 no 3303 0.0195303449895221 4701 403051
SGTC_827 3253-0474 693 µM -2.0654212408192 0.0191046102202571 no 3304 0.0194415802572615 4704 5402065
SGTC_2946 9065502 71.43 µM -2.06966720114177 0.018909433596037 no 3305 0.0192417601153711 4620 16489101
SGTC_85 0868-0259 160.055 µM -2.07013779252272 0.0188879064193918 no 3306 0.0192197213385414 4677 83173
SGTC_740 k014-0057 261 µM -2.07554892174864 0.0186418690929408 no 3307 0.0189678448666045 4688 4012779
SGTC_379 3970-0972 5.9 µM -2.09259117190575 0.0178847308575701 no 3308 0.0181928326529874 4706 2898042 YBL034C STU1
SGTC_2461 5755302 26.15 µM -2.09708101869666 0.0176896807862796 no 3309 0.0179932019773578 4693 2788904
SGTC_2325 6158266 200 µM -2.09900473659871 0.0176066668574171 no 3310 0.0179082415971156 4679 3623240
SGTC_841 0251-0215 91.2 µM -2.10030163165851 0.0175508899575725 no 3311 0.0178511579189133 4733 3888614
SGTC_1746 st038117 42 µM -2.13769607253308 0.0160062813884497 no 3312 0.0162707092411598 4703 2898218
SGTC_1148 3909-7663 27.7 µM -2.17502261819748 0.014582175989535 no 3313 0.0148142107404162 4731 4084526
SGTC_1701 st028638 40.4 µM -2.17639137565281 0.014532096001663 no 3314 0.0147630040635858 4723 3490878
SGTC_963 1269-2853 151 µM -2.1856256789785 0.0141980847325844 no 3315 0.0144215011646325 4710 3668223
SGTC_3286 9117135 37.221 µM -2.2157577754546 0.0131537851232991 no 3316 0.0133540478478537 4685 3438150
SGTC_2638 epoxomicin 18 µM -2.22238008024348 0.0129333840888931 no 3317 0.0131288151843342 4702 9915668 A protesome inhibitor.
SGTC_3177 9107506 49.47 µM -2.22315916614703 0.0129076659900966 no 3318 0.0131025345986023 4730 8897194
SGTC_1388 3346-4487 254 µM -2.22936857102493 0.0127042660456689 no 3319 0.0128946958038905 4737 3345614
SGTC_569 4130-2812 160 µM -2.2396555518486 0.012373399684766 no 3320 0.0125566466287107 4691 743552
SGTC_1973 st070275 50.2 µM -2.24498719325015 0.0122048705939126 no 3321 0.0123844773633557 4738 17118334
SGTC_3347 9188721 44.724 µM -2.27797939637408 0.0112056091951054 no 3322 0.0113639025968908 4715 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_745 0469-0705 296 µM -2.27805620718924 0.0112033683411349 no 3323 0.011361614490967 4757 3486736
SGTC_3047 9092122 49.47 µM -2.32409283093524 0.00992846514761594 no 3324 0.0100602596017007 4720 17173831
SGTC_1744 st037937 38.9 µM -2.3349631125875 0.00964660338277393 no 3325 0.00977267391216781 4737 1016152
SGTC_969 1313-0238 134 µM -2.36346230928484 0.00894058345341739 no 3326 0.00905253409840521 4754 5212874
SGTC_1529 apigenin 74 µM -2.36624079076278 0.00887423586384274 no 3327 0.00898487638660342 4743 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_994 3910-0338 138 µM -2.37720173051776 0.00861668884204396 no 3328 0.00872227242415352 4758 3479481
SGTC_2001 4023502 57.655 µM -2.37898746012173 0.00857535691320194 no 3329 0.00868013326369033 4731 108941 YCR052W RSC6
SGTC_3183 9108214 49.47 µM -2.48288395542021 0.00645105845492059 no 3330 0.0065161767556479 4779 4974831
SGTC_21 0849-0113 22.993 µM -2.50596233709284 0.00604787120451958 no 3331 0.00610593134830994 4765 1560156
SGTC_975 1335-0046 28.5 µM -2.50865731232956 0.00600227666623468 no 3332 0.00605954959738767 4760 16486740
SGTC_103 0844-0104 51.839 µM -2.53747327432412 0.00553347833556557 no 3333 0.0055827946544172 4617 5375804
SGTC_1916 st067606 49.2 µM -2.57267479369338 0.00500512656636613 no 3334 0.00504579914408943 4700 19590279
SGTC_2928 9011484 9.79 µM -2.60312668085269 0.00458482146140819 no 3335 0.00461889064143127 4735 2994751
SGTC_2921 7974240 10.71 µM -2.63606827413314 0.00416588627927728 no 3336 0.00419364269698067 4762 2979074 YDR527W RBA50
SGTC_140 0062-0056 502.533 µM -2.6413173838671 0.00410239073217805 no 3337 0.00412921573846194 4708 3758964
SGTC_1974 st069448 26.9 µM -2.64292053299371 0.00408317173299998 no 3338 0.00410971619623033 4773 6323587 YNR016C ACC1
SGTC_161 4065-0411 162.148 µM -2.64871958379999 0.00401432228197667 no 3339 0.0040398670744373 4761 1906281 YLR208W SEC13
SGTC_759 3486-0358 89.3 µM -2.67056920008221 0.00376415303773706 no 3340 0.00378613807362574 4769 875103
SGTC_2879 9041815 71.43 µM -2.69229967527587 0.00352930464156501 no 3341 0.0035480575684375 4784 4942971
SGTC_732 3970-1727 52.7 µM -2.74065562592825 0.00305327364755633 no 3342 0.00306583682146323 4789 1275699
SGTC_84 0443-0269 128.823 µM -2.76374212588986 0.00284708449223393 no 3343 0.00285713397611461 4774 6150058
SGTC_58 0957-0393 9 µM -2.85409837874335 0.00215545236841234 no 3344 0.00215795819534705 4415 6997992
SGTC_2610 ononetin 44.17 µM -2.87148360575956 0.0020413355200578 no 3345 0.00204274986569823 4763 259632
SGTC_2944 9067346 25.62 µM -2.90474077451146 0.00183818843411984 no 3346 0.00183778689019189 4742 6473075
SGTC_2724 maprotiline 69.64 µM -2.90829040289461 0.00181762911192552 no 3347 0.0018170534650453 4773 4011 A tricyclic antidepressant.
SGTC_911 3456-4043 236 µM -2.91290871096014 0.00179119309861512 no 3348 0.001790396328201 4767 914281
SGTC_735 3076-0345 636 µM -2.92320792566822 0.00173349384860583 no 3349 0.00173222541620744 4790 2888990
SGTC_2918 7977171 22.06 µM -2.95591685134339 0.00156128721481814 no 3350 0.00155870560047586 4783 2236483
SGTC_3168 9103419 49.47 µM -2.96861458982449 0.0014987487767603 no 3351 0.00149572770602294 4797 16649256
SGTC_865 0488-0499 301 µM -3.01391661605257 0.00129379899306773 no 3352 0.00128949338508455 4774 9634651
SGTC_675 1309-0189 238 µM -3.01658758251273 0.00128255543767312 no 3353 0.00127818678179482 4789 4246530
SGTC_1644 st010134 20.9 µM -3.05544756344549 0.00112876946651519 no 3354 0.00112362447462909 4799 3818134
SGTC_3262 9137218 49.47 µM -3.1353249874189 0.000864367246163966 yes 3355 0.000858319113299032 4801 17650664
SGTC_2123 5259487 200 µM -3.61067876093887 0.000156369876126738 yes 3356 0.000152698364071412 4803 2173474