SGTCid condition conc unit CRM1|YGR218W.score CRM1|YGR218W.strain.pval CRM1|YGR218W.strain.significant CRM1|YGR218W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_514 4466-0038 2.65 nM 5.76602715166416 3.34369020445641e-09 yes 1 4.05809946890086e-09 18 5722064 SGTC_513 4245-1575 41.7 µM 5.64752493227242 6.73991299335488e-09 yes 2 8.13871176228369e-09 12 719745 SGTC_365 0121-0052 13.6 µM 5.57838762367744 1.00812030038114e-08 yes 3 1.2137911196076e-08 2 3101739 SGTC_669 0108-0021 26.2 µM 4.72920995182318 9.68753835730876e-07 yes 4 1.12697603686649e-06 8 17201 SGTC_2931 9014674 55.67 µM 4.487391905576 3.12774025954632e-06 yes 5 3.60501863045261e-06 4 2996810 SGTC_2336 9001819 198.65 µM 4.35972685189575 5.67637040721034e-06 yes 6 6.51124460694484e-06 33 2989602 SGTC_944 3370-0224 231 µM 4.28417017975454 8.01768446896998e-06 yes 7 9.17112406508101e-06 2 4580514 SGTC_152 4469-0003 551.229 µM 4.12384933608201 1.63826980677364e-05 yes 8 1.8629633102555e-05 11 697280 SGTC_2534 helenine 20.12 µM 4.08228951257968 1.96374150599451e-05 yes 9 2.22970976751882e-05 19 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2133 5320837 200 µM 4.03872167506339 2.37035526032708e-05 yes 10 2.68716443852278e-05 5 2841355 SGTC_916 4466-0038 42 nM 3.92719392582521 3.80567502039824e-05 yes 11 4.29713423318411e-05 29 5722064 YGL116W CDC20 SGTC_3272 9137413 49.47 µM 3.9071567055929 4.13833563991254e-05 yes 12 4.66942947697664e-05 5 17614870 SGTC_1368 1852-0141 284 µM 3.81892651590744 5.95797147256333e-05 yes 13 6.70168396895922e-05 4 2838987 SGTC_525 k781-2675 26.7 µM 3.74655097369192 7.98953878409167e-05 yes 14 8.96412930696995e-05 43 3651118 YDL195W SEC31 SGTC_2135 5326629 150.42 µM 3.7129094634127 9.14139489804448e-05 yes 15 0.000102445098723317 7 5020077 SGTC_3225 9130819 49.47 µM 3.71259270362639 9.15294768903418e-05 yes 16 0.000102573440933036 11 4547121 SGTC_195 4234-0266 16.654 µM 3.7054270943823 9.41798648492872e-05 yes 17 0.000105517413581827 18 2303354 SGTC_1638 st008370 60.6 µM 3.69900014368613 9.66182465545288e-05 yes 18 0.000108225239229316 17 24207134 SGTC_2057 5236571 38.335 µM 3.64812833854542 0.000118120809697479 yes 19 0.00013207884241894 16 54684039 YBR257W POP4 SGTC_3296 9122258 64.045 µM 3.55638583778101 0.000168657194557503 yes 20 0.000187995878118291 9 4730474 SGTC_430 0958-0115 16.4 µM 3.41165496908378 0.000291055382544203 yes 21 0.000322848933668373 16 6833180 SGTC_350 k064-0020 19.8 µM 3.36362767742478 0.000347304266862412 yes 22 0.000384626224240254 10 2790705 SGTC_644 1498-1197 63.3 µM 3.33360855060943 0.000387429030182325 yes 23 0.000428636066017035 11 6741615 SGTC_339 3091-4833 71.4 µM 3.29629310778311 0.00044330271364351 yes 24 0.000489848720102662 29 3240077 SGTC_1516 st013856 110 µM 3.29387132306081 0.000447175392760507 yes 25 0.000494088623597997 8 5281404 A mutagen and neurotoxin. SGTC_2980 9014342 25.29 µM 3.26590396278507 0.000494228324068908 yes 26 0.000545576242586548 29 2996599 SGTC_2180 6301957 200 µM 3.25466446892293 0.000514397756506142 yes 27 0.000567632021719825 15 845462 SGTC_2537 larixol 68.93 µM 3.19533005148837 0.000634087566495237 yes 28 0.000698355071192511 14 6708759 SGTC_3273 9137859 49.47 µM 3.15870692239858 0.00072029068076644 yes 29 0.000792353832120441 11 2377234 SGTC_2756 carbadox 75.1 µM 3.15543255347561 0.000728501774137387 yes 30 0.000801301574405171 33 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3194 9111903 49.47 µM 3.14108377939892 0.000765511317429814 yes 31 0.000841619370408604 9 17087251 SGTC_2598 perillyl alcohol 100 µM 3.1290311059957 0.000797928536967656 yes 32 0.000876918704248561 18 10819 An apoptosis inducer. SGTC_3302 9125395 16.351 µM 3.12595716956206 0.000806396140878324 yes 33 0.000886136808265182 11 17599668 SGTC_2584 androsterone 48.74 µM 3.0425009406247 0.00107039825309743 no 34 0.00117310542025105 42 2754130 A steroid. SGTC_2787 5284540 71.43 µM 3.04248270490556 0.00107046373250034 no 35 0.00117317650130005 21 736958 SGTC_1175 0741-0056 27.6 µM 3.02404906933178 0.00113856411602227 no 36 0.00124707990566262 16 765927 SGTC_1630 st005209 31.3 µM 3.02283855977847 0.00114317214051414 no 37 0.00125207897809828 7 3367314 SGTC_1277 0873-0036 22 µM 2.98763394549709 0.00128489109623092 no 38 0.00140573033566707 8 5965735 SGTC_1203 3992-3522 103 µM 2.97960363257801 0.00131939026456462 no 39 0.00144310791099221 22 5322312 SGTC_2085 5307070 144.047 µM 2.96289499563777 0.00139390121922622 no 40 0.00152380256515468 18 2840351 SGTC_2214 7179297 48.276 µM 2.96225483463651 0.00139683095863684 no 41 0.0015269745459359 9 769744 SGTC_2429 5902844 64.44 µM 2.92561884995745 0.0015741720632097 no 42 0.00171885917868055 18 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_213 1246-0773 967 nM 2.88892608413067 0.00177213503758004 no 43 0.00193279964012337 10 6251622 SGTC_714 4296-0578 26.1 µM 2.86539368986849 0.00191074962276107 no 44 0.00208245545822756 4 1589775 SGTC_1310 1188-0297 994 nM 2.82991696639792 0.00213840214085903 no 45 0.00232800430060752 27 1588352 SGTC_530 4358-1714 28 µM 2.81756158268487 0.00222328678417647 no 46 0.00241949170006789 24 1564641 SGTC_2941 9056145 11.23 µM 2.79069690477892 0.00241848113610229 no 47 0.00262973491769731 21 2119517 SGTC_2651 TUB2.036 5 µM 2.75445630635722 0.00270635574898571 no 48 0.00293948696213262 65 15992207 YFL037W TUB2 SGTC_825 1988-2224 89.6 µM 2.75339229349776 0.00271525670144141 no 49 0.00294905870214396 25 1180859 SGTC_2930 9013230 14.89 µM 2.74038678254522 0.00282620956338107 no 50 0.00306834601710865 43 2995857 SGTC_643 k048-0106 28.4 µM 2.73097876477691 0.00290900328681948 no 51 0.00315732701310578 31 6763920 SGTC_2012 4023501 200 µM 2.72999098516397 0.00291782170875263 no 52 0.00316680287310613 29 3477460 SGTC_1587 estradiol valerate 56.1 µM 2.70929983419051 0.00310816837878972 no 53 0.00337126880847541 14 13791 A steroid. SGTC_257 daunorubicin 18.5 µM 2.66732952270775 0.0035289752966813 no 54 0.00382283334222632 36 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1686 st019653 115.5 µM 2.63072856251743 0.00393696914029732 no 55 0.0042601028010327 21 97252 SGTC_1268 0828-0275 2.46 µM 2.61840924604991 0.00408351098267501 no 56 0.00441703933619678 25 745337 SGTC_2316 5844804 197.44 µM 2.6019402679539 0.00428703423815541 no 57 0.00463489980410865 32 776813 SGTC_2871 9038510 12.99 µM 2.59799644051074 0.00433709815149138 no 58 0.00468847329865912 29 4945164 SGTC_1215 3852-0577 11.2 µM 2.59562064034714 0.00436750873626883 no 59 0.00472101248480034 23 2884876 SGTC_153 4077-0274 519.67 µM 2.5727112331353 0.00467067438085472 no 60 0.00504526796786832 26 3121976 SGTC_36 0335-0881 14.2 µM 2.56347576580182 0.00479810679696186 no 61 0.00518149675573922 66 23828853 SGTC_2016 5121758 140 µM 2.56102354016782 0.00483245968437201 no 62 0.00521821422091782 50 2795203 SGTC_2601 securinine 100 µM 2.53731039376585 0.00517613484016815 no 63 0.00558539306507823 48 442872 A GABA receptor antagonist. SGTC_60 0986-0278 202 µM 2.52272234199789 0.00539821126666911 no 64 0.00582251536625224 23 3110598 SGTC_1098 clofazimine 15.1 µM 2.52258775249744 0.00540029898353532 no 65 0.00582474401762232 62 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_325 2810-4341 181 µM 2.50886155700134 0.00561702232860175 no 66 0.00605604721586509 21 774970 SGTC_1324 1418-0026 34.4 µM 2.4904213745483 0.00592031997138588 no 67 0.00637958615840725 24 1372513 SGTC_1348 1493-0373 93.8 µM 2.47601356837248 0.00616731123905731 no 68 0.00664292645011937 27 3010129 SGTC_2975 9084847 53.72 µM 2.4751068361159 0.00618315621483926 no 69 0.00665981624683282 37 27211724 SGTC_1512 0259-0544 12.2 µM 2.46031639049828 0.00644675607545183 no 70 0.00694072902934131 26 18476 SGTC_1416 3966-0321 25.3 µM 2.44919023659964 0.00665155403128773 no 71 0.00715889024201766 30 582530 YLR208W SEC13 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.44039384304588 0.00681751765089567 no 72 0.00733562861965989 30 5024745 SGTC_462 ag-879 158 µM 2.42232305649447 0.00716997992813648 no 73 0.00771081700005636 43 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_200 k038-0079 37.545 µM 2.41619757413958 0.00729305063373976 no 74 0.00784177433741633 38 3436683 SGTC_2557 derrustone 83.84 µM 2.40299924861149 0.00756457334406286 no 75 0.00813061042166197 29 629853 An antioxidant. SGTC_1710 st031758 61.5 µM 2.39654849438193 0.00770049154065583 no 76 0.00827515164342454 27 5394341 SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.3588058444958 0.00853963847659888 no 77 0.00916692257510597 51 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1230 0170-0365 3.77 µM 2.35718044855554 0.00857751285782062 no 78 0.00920714814457487 54 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_448 monastrol 171 µM 2.315204364187 0.0096080095196164 no 79 0.0103008752701677 20 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2793 7325131 81.82 µM 2.31010356362298 0.00974032549067448 no 80 0.0104412106014608 33 4176441 SGTC_576 1073-0113 22.7 µM 2.30168808170849 0.00996210617084515 no 81 0.0106763843995127 78 5439563 SGTC_677 0929-0063 136 µM 2.28639427693381 0.0103764596830245 no 82 0.0111156014237214 21 1539583 SGTC_1719 st032227 49.2 µM 2.28487721852699 0.010418368866506 no 83 0.011160014101594 41 3125804 SGTC_490 phenamil 164 µM 2.28053188882701 0.010539227409044 no 84 0.0112880808570562 30 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2816 7982706 58.44 µM 2.25865350103642 0.0111664759742222 no 85 0.0119524735118906 47 2981853 SGTC_1959 st077091 55.8 µM 2.25385408230831 0.0113083367322572 no 86 0.0121026745871154 61 821356 YKL052C ASK1 SGTC_1295 1013-0063 9.78 µM 2.25148189691409 0.0113790301396626 no 87 0.0121775161064983 26 6826038 SGTC_1725 st036284 20.55 µM 2.24474907872369 0.0115817700693648 no 88 0.0123921227068113 31 707914 SGTC_1044 1222-0021 1.78 µM 2.23450707802042 0.0118961928734983 no 89 0.0127248636754557 77 4306703 SGTC_1317 1273-0028 910 nM 2.22580575625672 0.0121691092538668 no 90 0.0130135975457331 52 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2810 7959871 45.46 µM 2.22384274047438 0.0122314240157445 no 91 0.0130795133257669 47 2974535 SGTC_2619 obliquin 87.91 µM 2.2056982584384 0.0128206193801109 no 92 0.0137025669729118 66 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1280 0880-0253 10.1 µM 2.19732249951057 0.013100781508165 no 93 0.0139987109387508 30 6836607 SGTC_1914 st062367 72.6 µM 2.18749954674279 0.0134360786307201 no 94 0.0143530381349454 54 978205 SGTC_3277 9138724 49.47 µM 2.17494711323585 0.0138753075409847 no 95 0.0148170399015701 39 15943418 SGTC_3038 9091290 49.47 µM 2.16734406871976 0.0141473264825767 no 96 0.0151043143036059 30 25236843 SGTC_3276 9139060 49.47 µM 2.14937815910571 0.0148084220897712 no 97 0.0158022176705242 46 4870619 SGTC_2344 7990960 76.95 µM 2.13908618656787 0.0151989774907386 no 98 0.0162143444606066 88 140813 SGTC_52 0329-0193 875 nM 2.13557284259727 0.015334311028836 no 99 0.016357123482859 39 3739292 SGTC_1216 1165-0504 9.65 µM 2.13512368620512 0.015351686852507 no 100 0.0163754541696777 37 6304004 SGTC_2850 9015429 58.44 µM 2.13205680361545 0.0154707830796654 no 101 0.0165010885661628 42 6457570 SGTC_3147 9097027 49.47 µM 2.1183120870177 0.0160143221295807 no 102 0.0170743228264862 54 25236841 SGTC_341 1486-1430 230 µM 2.11800905645641 0.0160264876799614 no 103 0.017087150348745 75 2054753 YPL210C SRP72 SGTC_1871 st057448 67.3 µM 2.10439793692212 0.016581152176629 no 104 0.0176718746180228 52 691747 SGTC_3351 9150312 21.596 µM 2.1022046570261 0.0166720498339539 no 105 0.0177676760231315 66 4904905 SGTC_829 1635-0120 117 µM 2.09965305175712 0.0167783340353512 no 106 0.0178796861543647 93 285054 SGTC_2408 sulbentine 18.36 µM 2.08887528833507 0.0172336869017 no 107 0.0183594754287562 75 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_67 0335-0847 266 µM 2.07733441834765 0.0177329451631312 no 108 0.018885352252413 79 4552207 YOR254C SEC63 SGTC_2781 5567276 71.43 µM 2.06846775520344 0.0181248522917231 no 109 0.0192980298355135 51 2853274 SGTC_2704 st078022 71.1 µM 2.06787807597579 0.0181511759563673 no 110 0.0193257447477713 46 54697681 SGTC_1452 4194-0072 190 µM 2.06555628373187 0.0182551392310974 no 111 0.0194351979341489 49 1343545 SGTC_2805 7950783 58.44 µM 2.0602229513084 0.018495873589573 no 112 0.0196886158785963 51 1178958 YDL195W SEC31 SGTC_783 0848-0141 92.7 µM 2.05920935481318 0.0185419294060984 no 113 0.0197370937028382 59 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3245 9134821 49.47 µM 2.05733632047961 0.0186272933382661 no 114 0.0198269429681048 53 17014901 SGTC_812 4251-0442 148 µM 2.04374626598028 0.0192567387637698 no 115 0.0204893100110174 45 5723007 SGTC_3209 9113616 49.47 µM 2.04063741801878 0.0194032439897336 no 116 0.0206434400245549 58 16649353 SGTC_3123 9126162 49.47 µM 2.03856783873757 0.0195012975710391 no 117 0.0207465888868362 47 25239884 SGTC_1969 st069479 40.1 µM 2.03150703811002 0.0198390011619889 no 118 0.0211017931566126 40 3895485 SGTC_1736 st036774 51 µM 2.02957928207217 0.0199320596964405 no 119 0.0211996613021141 48 1272247 SGTC_2568 diosmetin 100 µM 2.00535426760389 0.0211333917880127 no 120 0.0224625935480851 67 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1588 farnesol 29.9 µM 1.99682229486331 0.0215708329705871 no 121 0.0229222453770063 44 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2576 guaiol 23.12 µM 1.99625076574496 0.021600407215289 no 122 0.0229533170908218 57 227829 SGTC_2545 solidagenone 89.61 µM 1.99410752626028 0.0217116162514073 no 123 0.023070152462735 21 6708572 An anti ulcer agent SGTC_535 2293-4129 48.2 µM 1.98748561238058 0.0220582765714678 no 124 0.0234343043682851 65 396118 YIL048W NEO1 SGTC_831 k061-1017 217 µM 1.97588984516954 0.0226765750855823 no 125 0.0240836272851065 79 1240153 SGTC_2227 7312221 64.1025 µM 1.97488136466727 0.0227310321326503 no 126 0.0241408063292153 32 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2332 7982454 138.89 µM 1.95076100346779 0.0240667217888252 no 127 0.0255427413814308 60 2981748 SGTC_302 1094-0063 18.9 µM 1.95010496630443 0.0241039526196819 no 128 0.0255818047257415 79 5440289 SGTC_1902 st060212 70.5 µM 1.94075063736536 0.0246401059805334 no 129 0.026144265533657 52 688944 SGTC_2326 6164455 177.58 µM 1.93545440803828 0.0249480770974048 no 130 0.0264672791223261 69 2888790 SGTC_1928 4'-methoxychalcone 40.3 µM 1.93393472505787 0.0250370389618431 no 131 0.0265605769873241 57 641818 SGTC_2723 salbutamol 83.58 µM 1.91887662619121 0.0259329949474739 no 132 0.0274999746844397 33 9884233 β2-adrenoceptor agonist SGTC_2783 7738165 71.43 µM 1.9138370180645 0.026238779011736 no 133 0.0278204919563391 50 17201110 SGTC_1753 st043925 64 µM 1.91034392195946 0.0264524907778962 no 134 0.0280444730382309 53 670181 SGTC_2895 9054447 58.44 µM 1.90468691544527 0.0268016775200203 no 135 0.0284103904275587 45 2697450 SGTC_2376 9072922 81.32 µM 1.90155988792822 0.0269963439894665 no 136 0.0286143580670352 49 17087968 SGTC_304 1310-0298 97 µM 1.90018543401679 0.0270822803000474 no 137 0.0287043945551592 56 1550234 SGTC_2892 9047358 58.44 µM 1.89534531534245 0.0273867231083116 no 138 0.0290233341785172 49 6466771 SGTC_996 3970-0799 1.8 µM 1.8868675733028 0.0279268483243698 no 139 0.0295890697689919 90 6615648 YGL040C HEM2 SGTC_2575 plumbagin 510 nM 1.8827337017741 0.0281934224455828 no 140 0.0298682328764714 87 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_288 1315-0019 35.1 µM 1.8737672190892 0.0287789139983781 no 141 0.0304812582313066 88 6811474 SGTC_715 0868-0130 184 µM 1.86107869890705 0.0296246902390374 no 142 0.0313665319102565 38 2876258 SGTC_1608 st001473 40.5 µM 1.85570064095238 0.0299893477149748 no 143 0.0317481197048022 82 7292267 SGTC_1028 k015-0029 4.8 µM 1.8489399902483 0.0304530243727184 no 144 0.0322332392003872 73 4588309 SGTC_1085 doxorubicin 7.67 µM 1.84794257592015 0.030521931786121 no 145 0.0323053252282333 78 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_135 0933-0004 26.348 µM 1.84670289687589 0.0306077562802685 no 146 0.0323951058146376 63 21230617 YGL099W LSG1 SGTC_650 1328-0195 38 µM 1.84136996551321 0.0309792439550784 no 147 0.0327836805311419 60 2780821 SGTC_2059 5238311 157 µM 1.84127516771578 0.0309858810959585 no 148 0.0327906224154075 61 703021 SGTC_1282 0886-0010 32.4 µM 1.83366626583702 0.0315224585289391 no 149 0.0333517745325403 87 2836211 YNL267W PIK1 SGTC_1080 nisoldipine 24.4 µM 1.82794354491269 0.0319310643838839 no 150 0.033779012446068 69 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1596 piperlongumine 63 µM 1.81901767041857 0.0325771022443306 no 151 0.0344543671271225 55 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.81437153661572 0.0329176239203644 no 152 0.0348102723996775 95 16725076 SGTC_453 enantio-paf c16 10 µM 1.80984540389387 0.0332521662476431 no 153 0.0351598823174295 95 13871343 A lipid and platelet activating factor SGTC_2739 tacrine 100.86 µM 1.80593358578913 0.0335435538250014 no 154 0.0354643570896022 63 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2319 6033012 152.6 µM 1.80245447605655 0.0338044722760468 no 155 0.0357369654722742 60 847246 SGTC_2006 4011487 200 µM 1.79662805393044 0.0342451673914847 no 156 0.0361973438175284 89 45595294 SGTC_3344 9148862 3.898 µM 1.79592154810308 0.0342989252120592 no 157 0.0362534974506533 50 4905352 SGTC_1136 pergolide 1.05886 µM 1.78299158527251 0.0352950723837759 no 158 0.0372938365560409 96 47811 A dopamine receptor agonist. SGTC_2239 6685329 187.64 µM 1.78243896406563 0.0353381706127743 no 159 0.0373388381273677 52 805680 SGTC_1514 1189-1591 158 µM 1.78209103403743 0.0353653273708953 no 160 0.0373671938426047 69 767698 YMR146C TIF34 SGTC_1092 toremifene 6.32 µM 1.77370266676802 0.0360252564788749 no 161 0.0380561725542703 67 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1618 st003135 44.5 µM 1.76974265729425 0.0363402844831849 no 162 0.0383850101390065 66 1270615 SGTC_299 1273-0059 1.44 µM 1.76618001161444 0.0366256247039961 no 163 0.0386828266813547 62 2848077 SGTC_1696 st025591 34.7925 µM 1.76119877983349 0.037027652832934 no 164 0.0391023822543816 56 2787147 SGTC_2842 9000675 19.48 µM 1.76050805948807 0.0370836835870596 no 165 0.0391608511057786 69 2989072 SGTC_476 mead acid 10 µM 1.75598423765082 0.0374523682320333 no 166 0.0395455500038856 49 5312531 An omega 9 fatty acid. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.75582987741441 0.0374650009839264 no 167 0.0395587305997754 49 364106 SGTC_459 nigericin 15.3 µM 1.75408771929462 0.0376078196069516 no 168 0.0397077388179956 85 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3192 9110362 49.47 µM 1.74867982390151 0.0380539816799277 no 169 0.0401731897597132 63 16649480 SGTC_2256 7954252 200 µM 1.74577963607157 0.0382950259106914 no 170 0.0404246254128271 75 2972920 SGTC_1371 2421-0008 32.7 µM 1.74478392951136 0.0383780689027671 no 171 0.0405112436077523 94 2827552 SGTC_2495 cafestol 54.53 µM 1.74405935274223 0.0384385916171075 no 172 0.0405743704327577 92 16667697 An anti-infammatory. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.74265118656428 0.0385564359532554 no 173 0.0406972815402813 83 1377 SGTC_1250 0485-0349 40.2 µM 1.74207909230756 0.0386043964819724 no 174 0.0407473027503706 71 6842794 YDL195W SEC31 SGTC_332 4112-0506 40.9 µM 1.74004205029989 0.0387755632145452 no 175 0.040925817262769 102 2790355 SGTC_169 k015-0017 16.025 µM 1.73266651156257 0.039400486515592 no 176 0.0415774800085543 67 1840002 SGTC_1675 st018485 24.5 µM 1.72667030734006 0.0399145572746945 no 177 0.0421134456009638 80 3323024 SGTC_597 k018-0003 82.8 µM 1.72663304091444 0.039917769189997 no 178 0.0421167940299241 54 6786234 SGTC_3042 9091578 49.47 µM 1.72395382876063 0.0401492358853469 no 179 0.0423580893065325 58 25236497 SGTC_222 nsc-310342 10.666 µM 1.72259507231571 0.040267039747175 no 180 0.0424808883693701 52 432556 SGTC_2427 5545055 42.75 µM 1.71906786925379 0.0405741581283373 no 181 0.0428010072760619 68 5372858 SGTC_201 4262-0159 12.803 µM 1.71682737911167 0.0407702262232311 no 182 0.0430053584162496 69 1341029 SGTC_186 3455-3465 67.277 µM 1.71525867431744 0.0409079625859457 no 183 0.0431489058339392 67 755278 SGTC_1001 4048-4355 44.4 µM 1.71200249384583 0.0411950686684849 no 184 0.0434481044396252 94 21824233 SGTC_2222 6885208 172.143 µM 1.69700184236336 0.0425388825617911 no 185 0.0448481561084769 51 609514 SGTC_1301 naphtanilide LB 4.81 µM 1.69353691142864 0.0428542704493664 no 186 0.045176657558917 88 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_155 k072-0202 43.6 µM 1.69107832565408 0.0430792020541684 no 187 0.0454109220951562 81 5857737 SGTC_3081 9117243 49.47 µM 1.68197820004318 0.0439200668646066 no 188 0.0462865336271149 119 45595589 SGTC_1494 4358-1428 177 µM 1.68151711766667 0.0439630214374843 no 189 0.0463312571949319 81 1564571 SGTC_2872 9044037 25.97 µM 1.68034319946371 0.0440725369593467 no 190 0.046445280264983 56 6465195 SGTC_1919 st067113 52.3 µM 1.67387610268951 0.044679805944448 no 191 0.0470774758400145 91 1268243 SGTC_3165 9101544 49.47 µM 1.67387269635776 0.0446801275702406 no 192 0.0470778106372136 78 5002184 SGTC_1431 4049-0260 9.09 µM 1.67142095353417 0.0449121051865106 no 193 0.0473192800050451 83 3854841 SGTC_2844 9010103 25.97 µM 1.66473745944565 0.045549407098728 no 194 0.0479825730306162 76 2480525 SGTC_1548 st061468 90.8 µM 1.6642901975733 0.045592313847218 no 195 0.0480272251872115 49 390799 SGTC_3134 9127454 49.47 µM 1.66297962549607 0.0457182268519563 no 196 0.0481582569889245 50 24262820 SGTC_272 doxorubicin 8.13 µM 1.66146621025038 0.0458639755696937 no 197 0.0483099248868902 77 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1893 st059353 36.1 µM 1.65833167312228 0.0461670331141601 no 198 0.0486252697150636 88 3112488 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.65218392016094 0.0467660879217552 no 199 0.0492485316937599 95 5282362 SGTC_2645 abamectin 100 µM 1.64567762899013 0.0474068552258394 no 200 0.0499150735977274 84 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_790 1575-0012 79.1 µM 1.64341088542346 0.0476317391636494 no 201 0.0501489747156702 76 378741 YLR208W SEC13 SGTC_483 fpl-64176 144 µM 1.64034431848361 0.0479373326213689 no 202 0.050466797852817 65 3423 SGTC_990 3985-0011 41.3 µM 1.63788293906153 0.0481837508552296 no 203 0.0507230578033408 81 5399565 YGL099W LSG1 SGTC_2253 7938677 135.83 µM 1.6313364746474 0.0488440772753867 no 204 0.051409670521515 65 2301972 SGTC_2419 paclitaxel 166.5 µM 1.62749704060852 0.049234703857805 no 205 0.0518157883142115 95 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2029 5175081 200 µM 1.62614145742174 0.0493732162068954 no 206 0.0519597832592771 79 1380876 SGTC_1352 1496-0991 99 µM 1.626119232252 0.0493754897454367 no 207 0.0519621467435956 83 3000039 SGTC_2044 5102272 200 µM 1.62127804955244 0.0498727170160266 no 208 0.0524790102122778 87 592666 SGTC_2317 5986382 200 µM 1.62066209375893 0.0499362658838417 no 209 0.0525450636913631 87 877883 SGTC_1308 1187-1617 41.4 µM 1.61926819105889 0.0500803148617691 no 210 0.0526947857835235 97 2882570 SGTC_210 3551-0445 56.827 µM 1.61383879348026 0.0506445618280653 no 211 0.053281198781011 74 2865180 YOR207C RET1 SGTC_3243 9134147 49.47 µM 1.60611498322053 0.0514559663895433 no 212 0.0541243241898012 69 24282180 SGTC_356 1634-0012 32.5 µM 1.59914214203226 0.0521973284363171 no 213 0.0548945113426961 104 735457 SGTC_2211 7117706 200 µM 1.59757428045391 0.0523651882552274 no 214 0.0550688770846129 69 822771 SGTC_3004 9076122 71.4286 µM 1.59647402417898 0.0524832406004124 no 215 0.0551915003635134 79 44782551 SGTC_328 k915-0120 63.5 µM 1.59515575365341 0.0526249629432069 no 216 0.0553387051831052 59 6624543 SGTC_418 lividomycin a 100 µM 1.59413034583147 0.0527354105678935 no 217 0.0554534216976196 76 72394 An antibiotic. SGTC_2822 7994718 71.43 µM 1.58390522488401 0.0538468555439916 no 218 0.0566076441080106 99 1018011 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.57879140910464 0.0544096303981727 no 219 0.0571919548796591 78 2374 Ca(2+)-ATPase inhibitor. SGTC_170 4197-0004 226 µM 1.57459247720437 0.0548751922877917 no 220 0.0576752702006238 92 218692 SGTC_1655 st012546 55.1 µM 1.57111099891175 0.0552635882632853 no 221 0.0580784341072603 70 720985 YLR208W SEC13 SGTC_2665 lovastatin 100 µM 1.56980872435995 0.0554094275968437 no 222 0.0582298086455449 83 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2242 6630449 61.2675 µM 1.56802665012107 0.0556094910739002 no 223 0.0584374564866257 76 691249 YDR170C SEC7 SGTC_1211 1056-0033 32.3 µM 1.56314632233032 0.056160297529008 no 224 0.0590090911293054 80 6741922 SGTC_2481 5478948 45.16 µM 1.56066128405556 0.0564424136394951 no 225 0.0593018453537882 83 77792 SGTC_2762 leflunomide 42.06 µM 1.56040347082285 0.0564717459440095 no 226 0.0593322825749207 108 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3037 9091026 49.47 µM 1.55940011085765 0.0565860160503759 no 227 0.0594508550455919 95 25236398 YIL048W NEO1 SGTC_395 anisomycin 6.25 µM 1.5561227601782 0.0569605349635302 no 228 0.0598394518896483 85 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_340 k038-0059 454 µM 1.55444665371499 0.0571528247448895 no 229 0.0600389560668134 90 23733424 SGTC_3231 9132313 49.47 µM 1.55294519898175 0.0573255112901054 no 230 0.0602181136592363 85 4905967 SGTC_1384 3089-0840 101 µM 1.5517334546098 0.0574651765875768 no 231 0.0603630071738182 56 1069836 SGTC_2092 5303694 80.6725 µM 1.55141739060686 0.0575016500121259 no 232 0.0604008451424888 96 1963699 SGTC_3234 9132280 49.47 µM 1.54918412113132 0.0577598859196408 no 233 0.0606687327358801 86 17612295 SGTC_845 0330-0138 4.51 µM 1.53988168523628 0.0588453606531127 no 234 0.061794597937543 100 9039800 SGTC_3221 9128209 49.47 µM 1.53551970361667 0.0593598302524618 no 235 0.0623281104738771 82 16460723 SGTC_1412 3909-8563 178 µM 1.53383378712969 0.0595596163122572 no 236 0.0625352742925869 87 23767530 SGTC_1 0258-0098 57.368 µM 1.53354985497889 0.0595933148967004 no 237 0.0625702163600356 105 6790032 YDR047W HEM12 SGTC_1023 4482-3888 16 µM 1.52931995153341 0.0600971137555166 no 238 0.063092572953506 107 3303168 SGTC_780 0109-0199 192 µM 1.52749781057554 0.0603151632693481 no 239 0.0633186356179127 110 610414 SGTC_2594 a-mangostin 100 µM 1.52603690340346 0.0604904319837786 no 240 0.0635003371080508 102 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_327 1273-0057 3.96 µM 1.52553280641674 0.0605510021599843 no 241 0.0635631286544318 87 3108138 SGTC_181 1447-1644 8.07 µM 1.52550310904031 0.0605545719514392 no 242 0.0635668293383789 105 534600 SGTC_2957 9076800 11.52 µM 1.52411308241427 0.0607218452452769 no 243 0.063740232602854 82 16459615 SGTC_3063 1327-0034 4 µM 1.52307204311287 0.0608473585454981 no 244 0.063870341165498 88 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_652 0437-0092 114 µM 1.5216644402556 0.0610173891947002 no 245 0.0640465909958694 89 3091274 SGTC_1743 st037606 46.3785 µM 1.52076230642288 0.061126557124478 no 246 0.0641597483461083 85 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2031 5180455 200 µM 1.5141299856817 0.0619338320553897 no 247 0.0649964374073474 85 29949 SGTC_2717 st081029 62.2815 µM 1.51135362763243 0.0622742262306665 no 248 0.0653491887113432 88 5292846 SGTC_455 paf C-16 10 µM 1.50096382855783 0.0635610239723707 no 249 0.0666824587252809 96 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_837 0091-0265 12.5 µM 1.50073346760805 0.0635897873550501 no 250 0.0667122565550113 112 759367 SGTC_481 bay k-8644 50 µM 1.50030682276844 0.06364308593177 no 251 0.0667674714654247 99 2303 A calcium channel antagonist. SGTC_2367 9070478 135.38 µM 1.49898651761549 0.0638082451917226 no 252 0.0669385648737948 97 572802 SGTC_804 1595-0054 20.9 µM 1.49753058640343 0.0639907564502035 no 253 0.0671276265357503 97 761523 Stimulates phospholipase C. SGTC_3141 9094609 49.47 µM 1.49561341040441 0.0642317068830496 no 254 0.0673772132312763 123 25236309 YDL196W YDL196W SGTC_759 3486-0358 89.3 µM 1.49513862045021 0.0642914872300146 no 255 0.0674391342244756 107 875103 SGTC_3227 9130768 49.47 µM 1.49358095071302 0.0644879155917309 no 256 0.0676425907264123 78 17720899 SGTC_218 alverine citrate 93.75 µM 1.49284254703201 0.0645811939876197 no 257 0.0677392035517182 104 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1509 1326-1131 80 µM 1.49204809261942 0.0646816699604158 no 258 0.0678432690600167 79 768313 SGTC_846 0335-0850 148 µM 1.49166374134712 0.0647303230604612 no 259 0.0678936594933314 85 6819598 SGTC_162 k030-0015 37.8 µM 1.49107725457867 0.0648046182421754 no 260 0.0679706066270439 99 1809920 YMR134W ERG29 SGTC_1801 st050089 28.441 µM 1.48515011019514 0.065559179703197 no 261 0.0687520321931998 111 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2593 nobiletin 86.24 µM 1.48397886818124 0.0657090888778125 no 262 0.0689072634042127 100 72344 An anti-infammatory. SGTC_1689 st020265 53.493 µM 1.48230222060013 0.0659241480407356 no 263 0.0691299488595213 97 5758320 YPR016C TIF6 SGTC_78 0336-0123 156.75 µM 1.47713156603247 0.0665908099238811 no 264 0.0698201867576643 86 6765896 SGTC_1746 st038117 42 µM 1.46627064829833 0.0680081077309748 no 265 0.0712872842289713 102 2898218 SGTC_1385 3091-4834 14.1 µM 1.4641539169225 0.0682870234355214 no 266 0.0715759491401055 88 4072814 SGTC_2766 oltipraz 83.91 µM 1.45879442876023 0.0689971749819359 no 267 0.0723108482355931 112 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1851 st056236 18.9 µM 1.45729054929317 0.0691974636611807 no 268 0.0725180972384523 106 5393171 SGTC_940 3232-1287 54.8 µM 1.45602348799085 0.0693665600327107 no 269 0.0726930633435219 99 1585493 YIL048W NEO1 SGTC_1273 0849-0096 14.1 µM 1.45411032133819 0.0696224856306379 no 270 0.0729578612373395 116 5286025 SGTC_1262 0737-0114 49.6 µM 1.45080845697829 0.0700658874449545 no 271 0.073416602052517 112 765919 SGTC_1606 st000094 49.2 µM 1.43611187147846 0.0720658622693726 no 272 0.0754852552853368 112 1242210 SGTC_3102 9121669 49.47 µM 1.43501453811092 0.0722169302555104 no 273 0.0756414774250429 119 41905072 SGTC_1153 4055-0057 267 µM 1.43382241432702 0.0723813228066002 no 274 0.0758114734466988 124 882706 SGTC_2089 5281248 129.67 µM 1.43103957882624 0.0727661884780303 no 275 0.0762094361049552 109 2737878 SGTC_2807 7945238 51.95 µM 1.43089101691497 0.0727867785375826 no 276 0.0762307259970007 113 17148797 SGTC_1699 st031318 29.054 µM 1.43027337000982 0.072872429643649 no 277 0.0763192873636852 111 5340658 SGTC_1657 st012939 43.4 µM 1.42593428216718 0.0734763215751518 no 278 0.0769436563037202 76 24207257 SGTC_76 0433-0009 400.328 µM 1.42575738372698 0.0735010223391519 no 279 0.0769691930662611 100 2841569 SGTC_2497 7-hydroxyflavone 100 µM 1.42567809034632 0.0735120963296257 no 280 0.0769806418166447 122 5281894 SGTC_707 0865-0008 204 µM 1.42476768057484 0.0736393341802648 no 281 0.0771121838127007 123 723043 SGTC_2094 5332512 191.667 µM 1.42329685258262 0.0738452510905207 no 282 0.0773250595053014 103 755774 SGTC_86 0417-1630 471.922 µM 1.42276697328163 0.0739195422762008 no 283 0.0774018592113607 147 3634867 SGTC_2375 9072683 200 µM 1.41801442155502 0.0745884243527773 no 284 0.078093277180133 108 16798029 SGTC_1486 3970-0793 4.53 µM 1.41772977438782 0.0746286322232706 no 285 0.0781348368918884 118 2844330 SGTC_2421 5690543 90.72 µM 1.40929860553088 0.0758270936544688 no 286 0.0793734454970827 120 3397993 SGTC_2988 9073640 71.4286 µM 1.40777861178892 0.0760447064098287 no 287 0.079598317767095 111 9102229 SGTC_2240 6690706 185.951 µM 1.40689926147059 0.0761708171603321 no 288 0.0797286313102921 94 805876 SGTC_1808 st050063 61.5 µM 1.40583368409214 0.0763238486437778 no 289 0.079886758586726 104 4011993 SGTC_2990 9074105 71.4286 µM 1.40423932004017 0.0765532578759801 no 290 0.0801237983740664 105 6502001 SGTC_2412 st077135 33.4 µM 1.40190665959323 0.0768898433462396 no 291 0.0804715607771797 104 13258915 SGTC_2349 9023730 187.07 µM 1.40022456729695 0.0771332539669465 no 292 0.0807230406268411 97 4126287 SGTC_695 3505-6186 243 µM 1.39759299854948 0.0775152344858154 no 293 0.0811176610231118 124 1819379 SGTC_902 1120-0002 2.07 µM 1.39671297855865 0.0776432921542675 no 294 0.08124994988574 121 3280475 SGTC_927 2425-1185 123 µM 1.39415836256675 0.0780159414842728 no 295 0.0816348941530826 131 730375 SGTC_2310 7668677 200 µM 1.390233494999 0.0785911152007356 no 296 0.0822289926978468 150 2197143 SGTC_924 2046-0044 21.3 µM 1.38819978669611 0.0788904084134909 no 297 0.0825381086156881 120 3623589 SGTC_2273 7815444 169.05 µM 1.38584932764587 0.0792373913719935 no 298 0.0828964582159512 123 2824616 SGTC_83 0170-0301 39.027 µM 1.38424875737094 0.0794743336067174 no 299 0.0831411492688679 83 3089716 SGTC_2217 6934799 96.0675 µM 1.38163937413458 0.0798617656908096 no 300 0.0835412289562284 104 675606 SGTC_3291 9121177 71.43 µM 1.38163627917545 0.0798622260660834 no 301 0.0835417043435598 90 17015612 SGTC_1922 5578187 25 µM 1.37127203206312 0.0814151923140404 no 302 0.0851450853926541 118 1350412 SGTC_2067 5224629 34.075 µM 1.36891636967403 0.0817713178417082 no 303 0.0855127090873162 121 2835000 SGTC_441 propafenone 146 µM 1.36600012721446 0.0822138160629815 no 304 0.0859694617304709 127 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2005 4024620 188 µM 1.36394717360022 0.082526402578745 no 305 0.0862920961673289 117 236743 SGTC_3058 9093861 49.47 µM 1.36383744523534 0.0825431351757457 no 306 0.0863093661217496 127 17217477 SGTC_2149 5554786 194.827 µM 1.36299951114404 0.0826709968751592 no 307 0.0864413323398016 102 745063 YPR165W RHO1 SGTC_591 4299-0174 154 µM 1.36093512620932 0.0829866405789672 no 308 0.0867670958660778 106 5509088 SGTC_37 0566-0070 1.56 µM 1.35962338754661 0.0831876754151094 no 309 0.0869745666354119 112 1626686 SGTC_1142 3253-1408 9.78 µM 1.35930888233868 0.0832359303280607 no 310 0.087024365292604 111 256655 SGTC_3226 9131256 49.47 µM 1.35799750157558 0.0834373639009112 no 311 0.0872322384676007 94 17178073 SGTC_2896 9052656 71.43 µM 1.35681699146523 0.0836190083584901 no 312 0.0874196836084058 165 6469436 SGTC_129 0088-0017 176.636 µM 1.35567412511715 0.0837951434924865 no 313 0.0876014378096074 98 182446 SGTC_966 1300-0360 30.2 µM 1.35506295324043 0.0838894497577001 no 314 0.0876987503402905 145 70588 SGTC_878 0828-0289 13.7 µM 1.35274233882276 0.0842482558207215 no 315 0.0880689797097614 124 745350 YLR208W SEC13 SGTC_266 formosanin C 406 nM 1.35080691905365 0.0845483841938567 no 316 0.0883786455523828 145 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2551 apiole 73.87 µM 1.35042614535166 0.0846075256316915 no 317 0.0884396644860425 95 10659 A possible DNA adduct former. SGTC_549 1661-1316 519 µM 1.35018586266579 0.0846448620933229 no 318 0.0884781859042837 131 2857282 SGTC_32 0928-0142 34.1 µM 1.34978230733929 0.0847075965705453 no 319 0.0885429108412836 119 2244242 SGTC_1732 st034308 51.822 µM 1.34800304429208 0.0849846067754648 no 320 0.0888287017310109 119 830119 SGTC_1118 chelidonine 707.474 nM 1.34756368295628 0.085053114560793 no 321 0.0888993789739214 96 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1131 3454-3128 32.3 µM 1.34665894844848 0.0851943164064589 no 322 0.0890450496725257 117 710982 SGTC_31 0508-1974 57.237 µM 1.34446149349441 0.0855380043458554 no 323 0.0893996001074273 96 6810525 SGTC_568 1193-0097 7.48 µM 1.34038683042859 0.0861780386501643 no 324 0.0900598075188555 141 3646150 SGTC_1960 st011366 51.8 µM 1.32084181970285 0.0892979734240352 no 325 0.093277056169374 135 3972846 SGTC_963 1269-2853 151 µM 1.31938046838539 0.0895345796912026 no 326 0.0935209740620188 112 3668223 SGTC_3190 9110366 49.47 µM 1.31864652292803 0.0896535879682126 no 327 0.0936436563390264 111 17123768 SGTC_584 0986-0246 15.4 µM 1.31664187256807 0.0899792386267109 no 328 0.093979348118042 162 53315 YDR232W HEM1 SGTC_2732 terfenadine 20 µM 1.31437113755116 0.0903491749061587 no 329 0.0943606692153904 120 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2893 9048488 25.97 µM 1.31240315928352 0.0906707002486743 no 330 0.0946920707440327 141 6467338 SGTC_220 paclitaxel 373.376 µM 1.31065780259833 0.0909565639011252 no 331 0.0949867005504643 102 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1219 1469-0211 33.1 µM 1.30870172501683 0.0912777344545558 no 332 0.0953177035879782 124 6822282 SGTC_720 r052-1644 49.9 µM 1.30650053121379 0.0916401555117291 no 333 0.0956911992480525 131 1422863 YOR257W CDC31 SGTC_1995 st072814 61.1 µM 1.30601624286223 0.0917200352819851 no 334 0.09577351697542 114 5769371 SGTC_808 0711-0032 135 µM 1.30379410438128 0.0920872219863162 no 335 0.0961518966593116 137 4252555 SGTC_2386 9075165 157.42 µM 1.30363686548759 0.092113245350532 no 336 0.0961787124441162 129 16452277 SGTC_2712 st079126 47.7 µM 1.30274649757661 0.0922607058024911 no 337 0.0963306609932318 113 3152970 SGTC_2306 7482397 179.52 µM 1.30129990306684 0.092500659511301 no 338 0.0965779102042507 136 891448 SGTC_3187 9109394 49.47 µM 1.29700137585496 0.0932164013177159 no 339 0.0973153567007487 135 17098090 SGTC_3014 9081533 49.47 µM 1.29508460957752 0.0935368754266792 no 340 0.0976455217458077 152 21367265 SGTC_1029 k015-0030 64.7 µM 1.29471033602037 0.0935995470063474 no 341 0.0977100865027968 137 2208316 SGTC_215 1287-0124 461.5 µM 1.29397424061145 0.0937228955968743 no 342 0.0978371593147196 104 5560863 SGTC_2998 9066762 71.4286 µM 1.29291051072148 0.0939013583392077 no 343 0.0980210059091233 113 4945196 SGTC_2528 xanthyletin 44.79 µM 1.29157418823497 0.0941259094268528 no 344 0.0982523238377887 128 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2841 9004761 38.96 µM 1.29060362481404 0.0942892477853456 no 345 0.0984205792204213 101 2991039 SGTC_2228 7354201 200 µM 1.28814239829858 0.094704390351027 no 346 0.0988481993871917 157 753451 SGTC_1058 3448-5425 97.3 µM 1.28337271904547 0.0955127387814872 no 347 0.099680763453307 143 7279705 SGTC_307 1501-1223 22.3 µM 1.2824902102608 0.0956628583156007 no 348 0.0998353684814693 118 2830329 SGTC_1619 st003326 88.7 µM 1.28245396872668 0.0956690269062281 no 349 0.0998417213087143 100 2849032 SGTC_2464 5717415 7.67 µM 1.28096628618323 0.0959224946769186 no 350 0.100102754077106 120 5285744 SGTC_1633 st005664 67.9 µM 1.28090219450942 0.095933425548482 no 351 0.10011401095899 115 2063822 SGTC_627 1391-0720 175 µM 1.27820250036645 0.0963946922906281 no 352 0.100589017379398 155 997839 SGTC_1525 8-methoxypsoralen 92.5 µM 1.27541709109563 0.0968723103051662 no 353 0.101080826237038 145 4114 Related to psoralen; DNA damaging agent. SGTC_101 0490-5701 117.494 µM 1.27290206227562 0.0973050565339334 no 354 0.101526398686795 106 4661669 SGTC_2449 5812982 45.77 µM 1.27277362514873 0.0973271939591304 no 355 0.10154919144536 106 776185 SGTC_758 0868-0029 16 µM 1.27182031702797 0.0974916216646724 no 356 0.101718484263435 114 762687 SGTC_375 3970-0961 9.27 µM 1.26815520379644 0.0981256821804708 no 357 0.102371265371407 137 2898222 SGTC_2381 9035592 200 µM 1.26647702867493 0.0984170108877115 no 358 0.1026711742569 121 4749657 SGTC_1809 st050081 57.6 µM 1.26436015236252 0.0987854001723208 no 359 0.103050394183479 129 5036894 SGTC_132 0417-1715 25.805 µM 1.26433791386482 0.0987892755744636 no 360 0.103054383409154 126 6769098 SGTC_1367 1812-0510 76.9 µM 1.26123107996487 0.09933178348524 no 361 0.103612801981673 125 1142582 YDR527W RBA50 SGTC_1788 fluconazole 20 µM 1.25441502813222 0.100529610619454 no 362 0.104845596514246 134 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_26 0302-0163 425.158 µM 1.25350840652442 0.100689727584227 no 363 0.105010370815157 164 3100915 SGTC_435 c-PAF 6.7 µM 1.25324767551902 0.100735809281275 no 364 0.105057792160771 136 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_463 ikarugamyin 104 µM 1.24856934779047 0.10156527421852 no 365 0.105911314684451 86 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2103 5378138 10 µM 1.24141211514536 0.102843855186604 no 366 0.107226772934676 130 244142 SGTC_1341 1486-1360 280 µM 1.2408913912959 0.102937332592379 no 367 0.107322936687553 138 3976547 SGTC_3208 9114115 49.47 µM 1.2366731942454 0.103696835509504 no 368 0.108104217121077 160 650895 SGTC_1553 gossypol 38.6 µM 1.23637200206713 0.103751221449641 no 369 0.108160159148388 116 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1054 3429-0080 167 µM 1.23119109112612 0.10468997414075 no 370 0.109125701316312 143 1162877 SGTC_1040 k898-0338 155 µM 1.22766573273622 0.105332257334242 no 371 0.109786237564651 146 20969351 SGTC_776 4476-4378 112 µM 1.22756911433488 0.10534990023607 no 372 0.109804380992823 132 2892008 SGTC_1353 1498-1206 8.11 µM 1.22723983261782 0.105410044436533 no 373 0.109866231126833 132 6756808 SGTC_1300 1094-0077 113 µM 1.22707018700037 0.105441040362023 no 374 0.109898106012494 136 5532636 SGTC_2869 9037858 32.47 µM 1.22449607812614 0.105912164556151 no 375 0.110382572445129 130 27187042 SGTC_2905 7799065 20.05 µM 1.22092152448617 0.106568914733853 no 376 0.111057866960865 135 1296806 SGTC_2846 9008642 19.48 µM 1.22045341695488 0.106655137017973 no 377 0.11114651913507 145 2992898 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.21707503158922 0.107278906345012 no 378 0.111787834774107 144 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2819 7996655 46.38 µM 1.21684311054663 0.107321823439845 no 379 0.111831957005012 105 6456960 SGTC_2691 st077356 60.2 µM 1.21547314612162 0.10757558849477 no 380 0.112092842412474 151 2839272 SGTC_985 1493-0307 8.71 µM 1.21412504254706 0.107825725964391 no 381 0.112349989232846 142 3278274 SGTC_2438 5259590 200 µM 1.21264809716862 0.108100250326294 no 382 0.112632195804451 143 1201127 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.21019524063052 0.108557281405839 no 383 0.113101991970955 130 4620898 SGTC_2733 amorolfine 100 µM 1.20926565043054 0.108730850974424 no 384 0.113280401467755 155 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2656 pseudo-anisatin 100 µM 1.20562500041922 0.109412540561597 no 385 0.113981057532857 139 6708809 A neurotoxin. SGTC_1905 st060207 84.5 µM 1.20525559658453 0.109481880344268 no 386 0.114052322777868 155 1948547 SGTC_1624 st003710 6.25 µM 1.20348016594371 0.109815581919604 no 387 0.114395281061012 131 24207033 SGTC_3169 9102970 49.47 µM 1.19803039429918 0.110844453397487 no 388 0.115452592280212 136 17027839 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.19262295101192 0.111872141483555 no 389 0.116508536596436 159 616764 SGTC_743 1275-0778 158 µM 1.18911001501052 0.11254341795319 no 390 0.117198188943708 170 2849257 YMR203W TOM40 SGTC_2136 5328288 199.296 µM 1.18809957403572 0.112737031815964 no 391 0.117397091080498 119 262395 SGTC_1572 epiandrosterone 68.9 µM 1.1880450593119 0.112747484316264 no 392 0.117407828925088 133 441302 A steroid. SGTC_1116 jasmonic acid  1.58368 µM 1.18625037793431 0.113091977938154 no 393 0.117761718329872 143 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1177 0983-0204 23.6 µM 1.18601638134097 0.113136949466527 no 394 0.117807915189735 151 766818 SGTC_209 4077-0173 175.592 µM 1.18312816380755 0.113693083573088 no 395 0.118379178757448 130 15993494 SGTC_359 0081-0058 15.9 µM 1.18277590684155 0.11376104470292 no 396 0.118448985781529 155 3494159 SGTC_2182 6325192 200 µM 1.18052318581943 0.114196348127842 no 397 0.118896097205025 144 736248 SGTC_3295 9122362 53.5725 µM 1.17781352307587 0.114721518450152 no 398 0.119435478126099 168 4730473 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.17678287752515 0.114921722325883 no 399 0.11964108924057 163 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_781 4335-2806 94.4 µM 1.17453812104278 0.115358628146567 no 400 0.12008977602765 159 845254 SGTC_1939 st074455 53.6 µM 1.17350364521769 0.115560369140564 no 401 0.120296947971457 148 1644229 SGTC_323 4013-0906 34.3 µM 1.17261494258912 0.115733881855594 no 402 0.120475127228249 139 2910086 SGTC_2260 7964312 200 µM 1.16983193584477 0.11627844042892 no 403 0.121034304529941 143 231951 SGTC_1322 1348-1070 12 µM 1.16966433367616 0.11631129355138 no 404 0.121068038294282 151 6758089 SGTC_1243 0416-0003 5.65 µM 1.1694537895078 0.116352573431878 no 405 0.121110424489521 142 2141977 SGTC_2458 5808907 16.39 µM 1.16867465050958 0.11650542400969 no 406 0.121267369479614 161 2731747 SGTC_788 1182-0090 188 µM 1.16834760488043 0.116569625857619 no 407 0.121333290149027 151 5715185 SGTC_2621 lithochol-11-enic acid 100 µM 1.16520082246849 0.117188648472372 no 408 0.121968856400601 144 6708711 SGTC_1472 k841-0093 193 µM 1.16407447338147 0.11741078434613 no 409 0.122196916193652 147 X1472 SGTC_1378 2093-0007 380 nM 1.16161338613144 0.11789719119708 no 410 0.122696271088979 158 3618014 SGTC_2821 7996764 71.43 µM 1.1614582431547 0.117927901200477 no 411 0.122727797507108 134 2987135 SGTC_3099 9120367 49.47 µM 1.16117402148571 0.117984176554376 no 412 0.12278556858955 158 24824940 SGTC_312 4092-0653 6.84 µM 1.16007765679433 0.118201432660211 no 413 0.123008595061944 177 1148278 SGTC_3311 9131146 2.8755 µM 1.15540103170625 0.119131331243806 no 414 0.123963119815242 189 4900406 YPR165W RHO1 SGTC_988 1497-1057 103 µM 1.15499085160261 0.119213136981931 no 415 0.124047086404916 154 3533044 SGTC_427 1354-0053 47.3 µM 1.14593021061159 0.121030297441398 no 416 0.125912014922256 132 6813657 SGTC_2372 9071633 200 µM 1.14563876005643 0.121089071178193 no 417 0.12597232630134 139 21321366 SGTC_1751 st044839 27.194 µM 1.14446619483272 0.121325732819222 no 418 0.126215174857468 139 5291326 SGTC_1555 citronellol 128 µM 1.14290301862795 0.12164173795004 no 419 0.126539429557236 143 8842 A terpine precursor. SGTC_3109 9122853 49.47 µM 1.13976342873731 0.122278170731012 no 420 0.127192436844999 182 1234709 SGTC_801 0866-0028 10.1 µM 1.13804914148647 0.122626662367245 no 421 0.127549981554579 145 6849771 SGTC_1500 4488-1866 171 µM 1.1351861420314 0.123210224170009 no 422 0.1281486673126 160 2900003 SGTC_496 calpeptin 138 µM 1.13507034585599 0.123233867647088 no 423 0.128172922607475 137 73364 A calpain inhibitor. SGTC_1312 1218-2183 165 µM 1.13081318760221 0.124105309950848 no 424 0.129066864072451 156 6744073 SGTC_736 0958-0254 92.6 µM 1.12738179154638 0.124810849627895 no 425 0.129790547109124 161 6812352 SGTC_2465 5809242 33.21 µM 1.12597855546856 0.125100179120875 no 426 0.130087298201496 172 2731748 SGTC_1439 4092-1168 46 µM 1.12517303654965 0.125266478377499 no 427 0.130257858301488 153 2886240 SGTC_2835 9006588 71.43 µM 1.1137327497125 0.127644995744186 no 428 0.132696927562821 130 2345538 SGTC_1854 st056233 32.9 µM 1.11297112431112 0.127804450335239 no 429 0.132860415635931 167 5393174 SGTC_2558 carylophyllene oxide 100 µM 1.11240449723294 0.127923169669126 no 430 0.132982135932895 161 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2687 chenodiol 100 µM 1.1117797617526 0.128054152627986 no 431 0.133116427773554 144 5702181 A cholesterol synthesis inhibitor. SGTC_1716 st033144 30.6155 µM 1.11095674598554 0.128226849491802 no 432 0.133293483962542 164 674617 SGTC_2444 5485484 36.41 µM 1.10862959896529 0.12871603952844 no 433 0.133795001921728 171 6790631 SGTC_2018 5133068 143 µM 1.1076201250873 0.128928643388279 no 434 0.134012954102134 157 785362 SGTC_1654 st012436 41.8 µM 1.10607082764979 0.129255412237717 no 435 0.134347932108176 153 4323132 SGTC_3232 9132874 49.47 µM 1.10438895230184 0.12961079299552 no 436 0.134712225537141 154 3784940 SGTC_753 1322-0200 289 µM 1.1027275120411 0.129962519793041 no 437 0.135072757724508 143 5403907 SGTC_1052 3253-3998 198 µM 1.10201216974011 0.13011416101286 no 438 0.135228190450713 146 5450317 SGTC_626 0214-0009 33 µM 1.10197471755587 0.130122103653665 no 439 0.135236331602965 169 3437874 SGTC_3318 9139014 38.6185 µM 1.1002533462386 0.130487524202893 no 440 0.135610876607118 179 16643984 SGTC_2798 7813637 45.45 µM 1.1001146633575 0.13051699529848 no 441 0.135641082859653 187 956368 SGTC_3007 9078383 71.4286 µM 1.09984785426672 0.130573707067763 no 442 0.135699208999232 165 6496995 SGTC_2354 9060492 162 µM 1.09962258685507 0.13062160218463 no 443 0.135748298289112 177 6471895 SGTC_3250 9135583 49.47 µM 1.09838659934971 0.130884607195999 no 444 0.136017855717832 154 7699353 SGTC_2770 toltrazuril 17.5 µM 1.098260796478 0.130911397216417 no 445 0.13604531269096 148 68591 Kills coccidiodes. SGTC_1953 st076800 12.1 µM 1.09470765238004 0.131669612909672 no 446 0.136822367508318 178 297591 SGTC_2157 5649910 96.377 µM 1.09204519696163 0.132239744463104 no 447 0.137406617866882 152 2858091 SGTC_1455 4262-0120 131 µM 1.09090564365787 0.132484284877879 no 448 0.137657201769833 156 1529587 SGTC_8 0354-0001 70 µM 1.09077847911177 0.132511592840775 no 449 0.137685184153346 175 4993152 SGTC_2520 obtusaquinone 4.71 µM 1.08995646144183 0.132688210669214 no 450 0.137866161660396 172 5967872 SGTC_1000 4048-0884 8.67 µM 1.08896506038569 0.132901437646463 no 451 0.138084646854466 159 13040088 SGTC_873 0591-4978 488 µM 1.08835231592831 0.133033342428725 no 452 0.138219801625914 181 3305145 SGTC_1827 berberine 7.24 µM 1.08764926173768 0.133184799065965 no 453 0.138374987344795 139 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2927 9011802 47.9 µM 1.08199989572302 0.134406130882443 no 454 0.139626287140622 149 43912568 SGTC_225 nsc-122657 1.016 µM 1.08176791206043 0.134456447083632 no 455 0.139677834038193 151 275685 SGTC_1810 st050138 53 µM 1.08049503679976 0.134732758074468 no 456 0.139960897876985 197 3444541 SGTC_1466 k213-0079 57.5 µM 1.07916395608909 0.135022120595215 no 457 0.140257322233355 193 3657981 SGTC_2355 9061122 103.12 µM 1.07900957890026 0.135055708084879 no 458 0.140291728758369 182 5302957 SGTC_2257 7960413 200 µM 1.07648525147931 0.135605733115727 no 459 0.140855146701287 172 2974689 YIL048W NEO1 SGTC_1089 terbinafine 2.25 µM 1.07577073137181 0.135761697990453 no 460 0.14101490257843 157 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3168 9103419 49.47 µM 1.07499633176508 0.135930871996892 no 461 0.141188185324177 158 16649256 SGTC_2514 salinomycin 42.74 µM 1.07420714007621 0.136103425897326 no 462 0.141364926480469 168 23682228 A polyether potassium ionophore. SGTC_2184 6075246 200 µM 1.06561865471181 0.137990961719072 no 463 0.14329803144971 167 2267320 SGTC_1330 1469-0054 61.8 µM 1.06448612199498 0.138241190325695 no 464 0.143554268994859 164 7102664 SGTC_1285 0929-0069 65.5 µM 1.0636244490676 0.138431780633846 no 465 0.14374943107814 148 1206237 SGTC_2216 7189485 200 µM 1.06286345506906 0.138600250981437 no 466 0.143921938988173 162 731273 SGTC_972 1319-0219 195 µM 1.06268803825303 0.138639104903056 no 467 0.143961723602822 187 23903702 SGTC_692 k241-0027 77.8 µM 1.06225613257888 0.138734801409909 no 468 0.144059711622123 160 3600480 SGTC_2452 5863136 48.41 µM 1.06135510749759 0.138934584604108 no 469 0.144264275232055 166 2184096 SGTC_279 1273-0055 2.93 µM 1.05709761612091 0.139881241794187 no 470 0.145233519539348 188 2847562 SGTC_1683 st010134 710 nM 1.05586179537443 0.140156846742401 no 471 0.145515680415264 154 3818134 SGTC_617 3770-0098 35 µM 1.05340923834571 0.140704892368874 no 472 0.146076735955422 168 5962639 SGTC_1790 st045711 43.5 µM 1.0532047786375 0.140750646286917 no 473 0.146123574411197 132 585119 SGTC_1331 1472-0049 76.2 µM 1.05306287084204 0.140782408295578 no 474 0.146156089152318 189 24051409 SGTC_2370 9071495 200 µM 1.05203389593075 0.141012860429714 no 475 0.146391999246542 182 21791103 SGTC_3176 9106582 49.47 µM 1.05143193263135 0.141147796389537 no 476 0.146530128088353 115 17018027 SGTC_1443 4112-3303 14 µM 1.05067810710721 0.141316897183567 no 477 0.146703227157177 183 704433 SGTC_858 0438-0351 2.77 µM 1.04768089457651 0.141990600516583 no 478 0.147392826434448 176 2799119 SGTC_2441 5730946 39.09 µM 1.04767441545594 0.141992059222742 no 479 0.14739431950089 159 1774275 SGTC_301 4119-0100 24.5 µM 1.04720841772099 0.142097000338694 no 480 0.147501731884662 176 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.04269365314324 0.143116427949287 no 481 0.148545099167589 191 65057 A dermal irritant. YDR527W RBA50 SGTC_746 1095-0025 46.6 µM 1.03997529198336 0.143732607421721 no 482 0.149175690002983 188 6749286 SGTC_2634 4'-methoxyflavone 100 µM 1.03886382698302 0.143985061532436 no 483 0.149434035856529 155 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2799 7812892 81.82 µM 1.03368632511861 0.145165000103459 no 484 0.150641414026552 210 20205235 SGTC_701 4424-0219 185 µM 1.03307062551881 0.145305748046879 no 485 0.150785424368079 175 2911779 SGTC_3346 9158254 43.5805 µM 1.03139739124237 0.145688710373347 no 486 0.151177251861578 197 17639500 SGTC_2736 butenafine 14.65 µM 1.03057850938296 0.145876379445466 no 487 0.151369259127633 168 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_693 4161-2696 114 µM 1.02573171219198 0.14699048054536 no 488 0.152509031045773 199 805759 SGTC_366 0181-0206 4.31 µM 1.02424181772548 0.147334096317851 no 489 0.152860535754018 161 274874 SGTC_629 3448-6466 76.7 µM 1.02422891922278 0.147337073460258 no 490 0.152863581188739 189 573744 SGTC_3026 9090633 49.47 µM 1.02374679142878 0.147448383752307 no 491 0.152977444091241 178 25236842 SGTC_675 1309-0189 238 µM 1.0236326795623 0.147474737345746 no 492 0.153004401829273 161 4246530 SGTC_811 0416-0114 265 µM 1.02254303058844 0.147726545541423 no 493 0.153261978640213 174 6612453 SGTC_274 sirtinol 40.1 µM 1.01938440427992 0.148458102235217 no 494 0.154010253618029 169 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3350 9150499 3.57 µM 1.01932480682952 0.148471928607237 no 495 0.154024395381326 177 4910996 YPR165W RHO1 SGTC_1552 6-methylflavone 10.6 µM 1.01903165532207 0.148539951128813 no 496 0.154093969239735 170 689013 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.0167009823883 0.14908149899668 no 497 0.154647849136867 175 688761 SGTC_488 nitrendipine 139 µM 1.01580601873665 0.149289799944255 no 498 0.154860884672117 163 4507 Dihydropyridine L-type calcium channel blocker. SGTC_182 3448-4371 550.524 µM 1.01554068421297 0.149351593337246 no 499 0.154924081662016 160 3491403 SGTC_2188 6126565 140.678 µM 1.01482379353269 0.149518634405602 no 500 0.155094914810302 172 874518 SGTC_1945 st075991 56.6 µM 1.01456225707811 0.149579605450181 no 501 0.15515726920653 165 1084980 SGTC_2193 5925765 200 µM 1.00599837249522 0.151585239651481 no 502 0.157208176477291 166 877370 SGTC_1477 0139-0234 16 µM 1.00470861453403 0.151888838574499 no 503 0.157518589423892 184 620880 SGTC_1414 3917-0015 5.4 µM 1.0044402709087 0.151952055295101 no 504 0.157583223702884 178 6618702 SGTC_2943 9068529 45.32 µM 1.00404626652141 0.15204490699909 no 505 0.157678156689625 224 3270634 SGTC_3322 9139058 2.11 µM 1.00358372942866 0.152153957305295 no 506 0.157789650150917 177 4908926 YPR165W RHO1 SGTC_1015 4130-4525 82 µM 1.00329100693996 0.152222998008111 no 507 0.157860236954825 187 1363237 SGTC_1715 st032160 10.2275 µM 1.00070281833268 0.152834345764368 no 508 0.158485252231445 165 5289825 SGTC_531 3788-1495 174 µM 1.00006307946558 0.1529857070555 no 509 0.158639991028871 168 2896655 SGTC_903 1134-0042 114 µM 0.999641193438939 0.153085579039434 no 510 0.158742090190914 187 701009 SGTC_1520 flindersine 88 µM 0.998673328280876 0.153314862505231 no 511 0.158976482589707 194 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_383 2324-0395 7.37 µM 0.995389729342265 0.154094428746414 no 512 0.159773375948562 170 3146421 SGTC_709 3807-1509 243 µM 0.993971222008825 0.154432009283661 no 513 0.160118439037103 214 1886677 YPL242C IQG1 SGTC_1660 st012960 28.1 µM 0.992777221768867 0.154716539653509 no 514 0.16040926638607 178 24207266 SGTC_385 1494-0393 12.4 µM 0.992426398704157 0.154800206619448 no 515 0.160494783310003 193 3090647 SGTC_2677 mitomycin C 100 µM 0.991190868428181 0.155095103282323 no 516 0.16079619431942 201 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_980 1473-0395 201 µM 0.989992085098468 0.155381583481117 no 517 0.161088993843972 207 768876 SGTC_678 1218-2179 85.9 µM 0.989654552255363 0.155462308621174 no 518 0.161171498042565 198 6820081 YOR116C RPO31 SGTC_2813 7971799 71.43 µM 0.985102699318276 0.156553642683326 no 519 0.162286813803846 182 2234054 SGTC_1375 2910-0797 186 µM 0.984733234240023 0.156642444936732 no 520 0.162377561763622 194 742508 SGTC_2928 9011484 9.79 µM 0.983640312665896 0.156905326626472 no 521 0.162646198325624 200 2994751 SGTC_896 0964-0007 44.5 µM 0.981998356028953 0.157300813652979 no 522 0.16305032905855 183 6756758 SGTC_592 k241-0073 46.5 µM 0.981693917618672 0.157374213637233 no 523 0.163125331401326 188 4230158 SGTC_387 norethindrone acetate 66.7 µM 0.979978202229253 0.157788292858238 no 524 0.163548439281848 177 541197 SGTC_1507 4075-3230 155 µM 0.979313939743298 0.157948801228184 no 525 0.163712442431919 179 659771 SGTC_1860 st056228 74.6 µM 0.978362550119192 0.158178875926744 no 526 0.163947521751744 207 688679 SGTC_637 1181-0519 7.26 µM 0.976909479632851 0.158530696471465 no 527 0.164306984139316 196 6252091 YGR060W ERG25 SGTC_673 1082-0474 110 µM 0.976197916490472 0.158703168714989 no 528 0.164483197768692 214 3098046 SGTC_362 0310-0100 9.03 µM 0.972439139447622 0.159616280475389 no 529 0.165416064236134 175 790235 SGTC_351 caspofungin 25 nM 0.970722051687199 0.16003455079133 no 530 0.165843353836916 202 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2124 5246320 200 µM 0.9694693030973 0.160340163194213 no 531 0.166155544449655 208 579342 SGTC_2219 9098279 200 µM 0.969208043734107 0.160403946362956 no 532 0.166220699275741 151 902349 SGTC_1904 st060225 78 µM 0.969165728210445 0.160414278722702 no 533 0.166231253792162 176 66595 SGTC_2191 5911152 200 µM 0.96914154320886 0.160420184271765 no 534 0.16623728631168 173 2875902 SGTC_1927 st060202 13.8 µM 0.968225832756328 0.160643889059459 no 535 0.166465798062702 193 688887 SGTC_1016 4226-1401 38 µM 0.961388695635456 0.162320613636567 no 536 0.168178383016578 196 2901613 SGTC_751 0833-0568 350 µM 0.959074110496598 0.162890809322653 no 537 0.168760705867421 201 6954252 SGTC_80 0159-0065 512.242 µM 0.956752009601606 0.163464163620595 no 538 0.169346220015036 173 1548079 SGTC_2492 derrusnin 100 µM 0.954276490179704 0.164076840485521 no 539 0.169971852568916 213 1715307 Part of coumarin class of compounds. SGTC_163 TUB2.036 7.546 µM 0.953628074610365 0.16423756549323 no 540 0.17013596976587 229 15992207 YJR013W GPI14 SGTC_998 3996-0085 177 µM 0.952064001814804 0.164625677632248 no 541 0.17053226209177 192 715391 SGTC_2969 9091408 28.7 µM 0.951587615085031 0.164744007159695 no 542 0.170653082505972 172 4286311 SGTC_29 0299-0004 12.984 µM 0.95000746001702 0.165136895685293 no 543 0.171054231030312 177 16871 A napthoquinone isolated from Swertia calycina. SGTC_2034 5197015 53.07 µM 0.949489847773654 0.165265726161466 no 544 0.171185766508315 200 780676 SGTC_1055 3448-0672 86 µM 0.947213637392379 0.165833032479805 no 545 0.171764963795233 191 748378 SGTC_2371 9071574 200 µM 0.946068674868522 0.166118869999784 no 546 0.172056779923753 202 45596039 SGTC_2885 9057732 51.95 µM 0.944990333024684 0.166388366680644 no 547 0.172331905669593 224 6471414 SGTC_2516 gossypol 71.55 µM 0.944731881137063 0.166453000289537 no 548 0.172397888183485 196 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2294 7971431 200 µM 0.942985314160181 0.166890206313675 no 549 0.172844207360438 200 5741572 SGTC_1723 st034307 2.5525 µM 0.942398589729683 0.167037243045108 no 550 0.172994304497161 219 867466 SGTC_2688 kanamycin b 96.69 µM 0.939770816429366 0.167696803643766 no 551 0.173667565677042 208 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_885 0865-0106 16.8 µM 0.938496617920354 0.168017225353902 no 552 0.173994627112408 188 2793380 SGTC_2272 7805186 180 µM 0.938374186124264 0.168048033917956 no 553 0.174026073530143 225 2956062 YPR165W RHO1 SGTC_2989 9073649 71.4286 µM 0.936611258416853 0.168492057574747 no 554 0.174479279329292 209 21367202 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.934663205572896 0.168983584664224 no 555 0.174980947327763 177 4000243 SGTC_2768 sulfasalazine 50.2 µM 0.932599270460787 0.169505354617967 no 556 0.175513455097159 185 5384001 An antioxidant and salicylic acid derivative. SGTC_1830 st055982 50.3 µM 0.931790443532321 0.169710110500365 no 557 0.175722417176933 203 455313 An antimicrobial agent. SGTC_752 1896-0090 130 µM 0.931246356838573 0.169847936162733 no 558 0.175863071714791 210 772567 SGTC_2249 haloperidol 116.36 µM 0.92903010531884 0.17041008863918 no 559 0.176436742345685 222 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2281 7943571 200 µM 0.927944685637425 0.170685839697444 no 560 0.176718131621144 210 1244024 SGTC_1916 st067606 49.2 µM 0.927943637309296 0.170686106163376 no 561 0.176718403531707 204 19590279 SGTC_2155 5570423 76 µM 0.926464493997759 0.17106234270476 no 562 0.17710232043056 201 797402 SGTC_2979 9012552 45.46 µM 0.925230631743504 0.171376594765037 no 563 0.177422976519806 228 17100905 SGTC_2608 thymoquinone 42.66 µM 0.92467001028828 0.171519501146172 no 564 0.177568791830637 204 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_640 3381-0960 37.1 µM 0.924049058605806 0.171677874985647 no 565 0.177730387033906 212 1745025 SGTC_1845 st056753 3.01 µM 0.923611676853979 0.171789485337467 no 566 0.177844266045064 201 5375839 SGTC_762 1165-0429 115 µM 0.922487093269978 0.172076667417988 no 567 0.178137279776805 210 5967793 SGTC_2475 5812728 15.03 µM 0.922309250888664 0.172122110625363 no 568 0.178183645011792 196 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2280 7785178 200 µM 0.918472146397224 0.173104452466494 no 569 0.179185867375003 191 2954328 SGTC_138 0850-0259 40.9225 µM 0.9176905581455 0.173304984767812 no 570 0.179390446096511 217 6813004 SGTC_1350 1495-0454 146 µM 0.915648739081629 0.173829552392967 no 571 0.179925579572813 190 1069057 SGTC_1563 conessine 56.1 µM 0.915336489081976 0.173909862068893 no 572 0.180007504413569 184 441082 An anti-amoebic, histamine inhibitor. SGTC_69 0096-0274 206.684 µM 0.913661973075264 0.174340944540155 no 573 0.180447245659781 253 6741392 SGTC_769 0302-0231 76 µM 0.913485560198233 0.174386399247705 no 574 0.180493612293191 233 571869 YER009W NTF2 SGTC_3101 9120531 49.47 µM 0.911449291928585 0.174911610935427 no 575 0.181029345971165 210 24824904 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.911372751984818 0.174931372326027 no 576 0.181049502720494 193 61125 An anti-inflammatory. SGTC_2267 7931562 200 µM 0.910611438385474 0.175128008457834 no 577 0.181250070757407 179 934880 SGTC_1007 4101-0031 70 µM 0.908970547050284 0.175552303151747 no 578 0.181682836465842 230 1146276 SGTC_1659 st012954 42.1 µM 0.908913306110049 0.175567116020318 no 579 0.181697944748814 201 24207262 SGTC_2952 9073731 13.78 µM 0.908403514625733 0.175699075317079 no 580 0.181832534759464 209 16457353 SGTC_1527 coumarin 137 µM 0.906853315651119 0.176100729569267 no 581 0.182242185666828 220 323 A hepatotoxic, DNA x-linker. SGTC_2904 7225135 42.03 µM 0.903675068431174 0.176926024503689 no 582 0.183083861460752 241 4446116 SGTC_1410 3909-8106 77.9 µM 0.90330274041679 0.177022866547939 no 583 0.183182621255914 219 1039210 SGTC_107 0358-0022 2.6945 µM 0.902545732303921 0.177219866646044 no 584 0.18338351966334 199 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1652 st011932 78 µM 0.900478909081352 0.177758431378977 no 585 0.183932722167555 212 1551076 SGTC_686 1319-0111 510 µM 0.899346292624922 0.178054001633206 no 586 0.184234118402853 224 4562600 SGTC_2482 5981709 142.65 µM 0.894389994003675 0.179351050679604 no 587 0.185556632110646 217 877755 SGTC_1929 genistein trimethyl ether 50.5 µM 0.894167110486176 0.179409517902676 no 588 0.185616243323638 203 136420 SGTC_224 benfluorex 43.875 µM 0.893876432883535 0.179485786999696 no 589 0.185694004225668 224 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_284 0988-0104 32.6 µM 0.890486917909098 0.180376644794042 no 590 0.18660224490873 224 4666532 SGTC_2856 9022925 19.48 µM 0.89004293081507 0.180493541973473 no 591 0.186721417303681 199 4944862 SGTC_1569 carminic acid 40.6 µM 0.889015465322368 0.180764245121811 no 592 0.186997384146163 211 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_983 1491-0821 12.2 µM 0.887625774745966 0.181130787293662 no 593 0.187371042199117 194 46495113 SGTC_569 4130-2812 160 µM 0.887255776494765 0.181228455765 no 594 0.187470604558927 200 743552 SGTC_2125 5246583 200 µM 0.886590117343926 0.181404252901686 no 595 0.187649808243216 220 835267 SGTC_2399 5884133 200 µM 0.886519272986187 0.181422968813739 no 596 0.187668886650354 210 722445 SGTC_410 α-linolenic acid 100 µM 0.884483061336261 0.181961418996582 no 597 0.188217751149465 224 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.883016802360254 0.182349770703488 no 598 0.188613596655102 209 676296 Flavone; oxidizing agent. SGTC_1246 0422-0085 105 µM 0.880914637122206 0.182907450548524 no 599 0.189182012242286 224 264295 SGTC_2259 7964009 200 µM 0.88057225514214 0.18299838117699 no 600 0.189274690506568 187 313134 SGTC_3022 9087993 49.47 µM 0.880174470707851 0.183104061137609 no 601 0.189382400575722 218 17173644 SGTC_1333 1482-0047 286 µM 0.880012996150956 0.183146971176376 no 602 0.189426134607776 210 3811116 SGTC_2515 chrysin 20.77 µM 0.879671386892206 0.183237770646108 no 603 0.189518677097769 198 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2060 5238662 140 µM 0.877655629804717 0.183774128694057 no 604 0.190065315089905 224 790130 SGTC_255 tunicamycin 200.472 nM 0.876997985050173 0.18394932794668 no 605 0.190243866254753 208 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_696 1560-0013 611 µM 0.876866625845204 0.183984335034258 no 606 0.190279542744661 235 1650269 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.875647868525161 0.184309330315901 no 607 0.190610746943235 200 1241132 A phosphatase inhibitor. SGTC_1020 4335-0961 93.3 µM 0.874448799174721 0.184629423949903 no 608 0.190936945952527 226 669075 SGTC_2478 5763493 32.33 µM 0.874424824096578 0.184635827661298 no 609 0.19094347170637 224 1365576 YLR208W SEC13 SGTC_3023 9089636 49.47 µM 0.873934967313162 0.184766697991333 no 610 0.191076835313888 220 17249241 SGTC_1797 st048695 56.8 µM 0.873391181248887 0.184912043605218 no 611 0.191224948060549 230 592262 YIL048W NEO1 SGTC_1188 1403-0014 4.57 µM 0.872282283488773 0.185208654945867 no 612 0.191527200108739 216 9614867 SGTC_2229 7354935 190 µM 0.871913240231296 0.185307433252583 no 613 0.191627855033295 235 318112 SGTC_2090 5301565 104.445 µM 0.871590708590913 0.185393789017339 no 614 0.191715850645722 219 2056344 SGTC_1046 2001-0062 216 µM 0.869653553308785 0.185912975308049 no 615 0.192244880998572 223 739778 SGTC_1180 1193-0155 285 µM 0.865918508547291 0.186916564644299 no 616 0.193267426213937 219 2921347 SGTC_1366 1683-0113 21.9 µM 0.864249049937224 0.187366222477558 no 617 0.193725546201913 220 708623 SGTC_965 1291-5240 308 µM 0.863370665297293 0.187603077921665 no 618 0.193966851350134 225 2834598 SGTC_3282 9108498 15.4605 µM 0.863208481368257 0.187646830862014 no 619 0.194011425677711 221 16459645 SGTC_3104 9120930 49.47 µM 0.860380253146575 0.188410825328665 no 620 0.194789733683229 221 17014836 SGTC_2388 9080168 200 µM 0.859830740221387 0.188559488553882 no 621 0.194941175730591 250 15943073 SGTC_2653 dihydrofissinolide 100 µM 0.859384546634051 0.188680253332857 no 622 0.195064196318714 223 6857746 SGTC_1602 st001878 87.6 µM 0.859301104001979 0.188702842836538 no 623 0.195087207627367 240 595405 YLR310C CDC25 SGTC_1603 st002045 67.8 µM 0.858195364288877 0.189002344949981 no 624 0.195392297684468 221 5887985 SGTC_404 fumagillin 50 µM 0.858087475120648 0.189031583623229 no 625 0.195422081424219 236 12015870 A methionine aminopeptidase binder. SGTC_2912 7964298 10.93 µM 0.856984091607829 0.189330767729689 no 626 0.195726838291441 227 2975850 SGTC_2731 amoxapine 43.43 µM 0.856469993630202 0.189470265661994 no 627 0.195868931709696 259 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1779 st039427 55 µM 0.855584196942219 0.189710770521903 no 628 0.196113907089916 220 1124498 SGTC_2794 7785382 27.27 µM 0.854123475365651 0.190107784569958 no 629 0.196518288988672 227 2205081 SGTC_2635 hydroquinidine 100 µM 0.853599381872069 0.190250353934612 no 630 0.196663500573616 198 442912 An experimental heart treatment. SGTC_635 k038-0028 24.7 µM 0.850757438431744 0.191024592179749 no 631 0.197452054472576 222 4035102 SGTC_895 0964-0006 13.7 µM 0.850502984471527 0.191094007880916 no 632 0.197522750932826 250 6738897 SGTC_3161 9100388 49.47 µM 0.849252074769673 0.191435484178171 no 633 0.197870521115883 240 25236368 SGTC_2864 9034755 47.6 µM 0.848490530293205 0.191643555382031 no 634 0.198082422032916 220 4930451 SGTC_1404 3909-7820 48.3 µM 0.8478446559706 0.191820131387767 no 635 0.19826224489498 214 23741373 SGTC_2563 tomatine 8.54 µM 0.846049397579166 0.192311461236207 no 636 0.198762593986064 221 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1999 st074831 12.5 µM 0.845554165621868 0.192447132618859 no 637 0.198900751907681 230 17112523 SGTC_1100 amiodarone 5.07 µM 0.842856314876155 0.193187250162451 no 638 0.199654404003937 211 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2134 5324836 1.464 µM 0.842609545438449 0.193255034519669 no 639 0.199723425398342 230 699272 SGTC_2824 7998404 51.95 µM 0.841450869325409 0.193573501833955 no 640 0.200047698921175 226 837851 SGTC_1135 dihydrocapsaicin 536.708 nM 0.840506463968604 0.193833312487657 no 641 0.20031223942534 233 107982 A Capsaicinoid. SGTC_2947 9072639 7.68 µM 0.839729870108861 0.194047116533593 no 642 0.200529931095109 239 16488146 SGTC_2334 9017922 200 µM 0.838792056476296 0.19430549742918 no 643 0.200793004530971 217 3163164 SGTC_1692 fluoroquinolonic acid 71 µM 0.83628883061659 0.194996196674532 no 644 0.201496217588218 218 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_105 0111-0055 734.78 µM 0.834737715280966 0.195424934193644 no 645 0.201932700726169 202 5179370 SGTC_585 0kpi-0023 191 µM 0.832930800529092 0.195925097561493 no 646 0.202441878773352 194 64601 SGTC_333 3486-0131 40.1 µM 0.832516294260928 0.196039944472272 no 647 0.202558792385936 223 6744690 SGTC_2046 4110841 106 µM 0.832054826261238 0.196167851057376 no 648 0.202688999263169 232 44119630 YMR134W ERG29 SGTC_3207 9114163 49.47 µM 0.831689982722512 0.19626901173938 no 649 0.202791978173899 253 849233 SGTC_1840 st055363 71 µM 0.831017049173498 0.196455679918525 no 650 0.202981999006807 234 676033 SGTC_1631 benzylvanillin 81.9 µM 0.828677619252558 0.197105462029304 no 651 0.203643426687861 211 75506 SGTC_3024 9090631 49.47 µM 0.828202503663423 0.197237585203195 no 652 0.203777913092893 216 25236383 SGTC_1691 st019933 84.6 µM 0.826709509796909 0.197653115046792 no 653 0.204200864969354 248 6176082 SGTC_112 phenothiazine 287.218 µM 0.826411132744352 0.197736222699878 no 654 0.204285455171584 224 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3189 9110682 49.47 µM 0.826261408430056 0.197777933716278 no 655 0.204327910029674 215 17122418 SGTC_3059 1327-0034 3 µM 0.826230423862705 0.197786566230012 no 656 0.204336696469138 225 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1024 4507-0395 26 µM 0.82484984756845 0.198171435317004 no 657 0.204728421240443 221 4201836 SGTC_148 3253-0744 288.01 µM 0.823276976945014 0.198610461642131 no 658 0.20517525151851 239 6893655 SGTC_2177 5811945 192 µM 0.820013448843885 0.199523260727186 no 659 0.206104220197464 226 5343475 SGTC_2971 9092186 9.93 µM 0.819494423983627 0.199668662800123 no 660 0.206252191001948 217 25236400 SGTC_2159 5658611 73.75 µM 0.819301735950456 0.199722659558943 no 661 0.206307141202591 217 793844 SGTC_3175 9106517 49.47 µM 0.81865806701017 0.199903097886886 no 662 0.206490763689361 227 41468073 SGTC_1604 st002052 72.4 µM 0.814744201443865 0.201002372176323 no 663 0.20760937319865 224 6254834 YHR062C RPP1 SGTC_1315 1237-0019 3.69 µM 0.812559400869898 0.201617583762715 no 664 0.208235358321675 215 825140 SGTC_426 0988-0037 14.6 µM 0.811545758127885 0.201903395105954 no 665 0.208526163209267 247 5383008 SGTC_2366 9070441 60.58 µM 0.811507700094886 0.201914130845299 no 666 0.20853708637499 215 6837235 SGTC_1979 st071809 45.3 µM 0.811358635997869 0.201956183426371 no 667 0.20857987301772 244 4976333 SGTC_3130 9127414 49.47 µM 0.810988878019454 0.202060518747894 no 668 0.208686028911745 235 1494646 SGTC_3257 9139206 32.98 µM 0.810832985371215 0.202104516942145 no 669 0.208730794548793 236 4910041 SGTC_1503 4585-0012 61.3 µM 0.807865150716643 0.202943233557801 no 670 0.209584107426076 219 2922052 SGTC_1690 st023502 41.2 µM 0.807618961554517 0.203012900405881 no 671 0.209654983863536 232 24207482 SGTC_2700 st077718 96.8 µM 0.807313774659869 0.203099282311552 no 672 0.209742864971569 225 904970 SGTC_34 0469-0683 81.75 µM 0.807203751706027 0.20313042924067 no 673 0.209774552308227 210 3690923 SGTC_1235 benzylparaben 21.5 µM 0.806388626505075 0.203361275779555 no 674 0.210009401397368 240 7180 SGTC_1880 MG-132 525 µM 0.8063117687972 0.203383050245747 no 675 0.210031553156419 235 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3312 9133330 71.43 µM 0.805979203010446 0.203477285095892 no 676 0.210127420355262 243 17617324 SGTC_2761 levamisole 97.89 µM 0.805641402713135 0.203573029840157 no 677 0.210224822791938 218 26879 An alkaline phosphatase inhibitor. SGTC_1359 1582-0056 520 nM 0.805512843783068 0.203609475118592 no 678 0.210261898856997 238 3661189 SGTC_2147 5545932 89.7195 µM 0.803767889557691 0.204104538368739 no 679 0.210765518831416 260 797404 SGTC_1756 st041558 35.5 µM 0.801797218788358 0.204664501221086 no 680 0.211335133863557 252 3955792 SGTC_2734 clemastine 41.6 µM 0.801500726875983 0.204748827934323 no 681 0.211420911718197 267 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2873 9040596 71.43 µM 0.801135447490697 0.204852747237619 no 682 0.211526618455035 252 6463863 SGTC_1208 2323-2347 50.3 µM 0.800871070870957 0.204927980006093 no 683 0.211603144644761 238 5412760 SGTC_2644 guaiazulene 100 µM 0.797864866091853 0.205784600420891 no 684 0.212474456928913 220 3515 A coloring agent. SGTC_2484 5809818 12.04 µM 0.79641224382013 0.20619928654589 no 685 0.21289623199881 221 2870548 SGTC_3156 9099931 49.47 µM 0.796064437655906 0.206298649675311 no 686 0.212997291457402 246 18111053 SGTC_1946 st076057 65.1 µM 0.796006270786773 0.206315269867661 no 687 0.213014195304888 228 953009 SGTC_171 k064-0041 9.68 µM 0.795335180330004 0.206507079924094 no 688 0.213209277199923 223 53325 SGTC_699 0375-0592 111 µM 0.792218627499651 0.207399231777739 no 689 0.214116604493955 207 762578 SGTC_177 1327-0068 8.361 µM 0.792184368785767 0.207409051403077 no 690 0.214126590760586 249 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.790939476746123 0.207766063049406 no 691 0.214489655220452 249 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2156 5649887 115 µM 0.790326422621492 0.207942008760304 no 692 0.214668579814909 246 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2833 9001315 45.46 µM 0.788099916107858 0.208581752660346 no 693 0.215319132135332 237 2989378 SGTC_713 1488-1073 324 µM 0.787823452864491 0.20866126997107 no 694 0.215399990378264 250 3312542 SGTC_3172 9105863 49.47 µM 0.786645589949823 0.209000251139798 no 695 0.215744681713178 244 2348785 SGTC_317 4495-0002 170 µM 0.786106711087404 0.209155444995139 no 696 0.215902486467656 223 15991618 SGTC_1170 0310-0127 64.8 µM 0.785301221196784 0.209387547677503 no 697 0.216138489994069 259 774975 SGTC_1978 st071761 42 µM 0.785221786396979 0.209410445098553 no 698 0.216161771986598 233 5147680 SGTC_2469 5655019 90.81 µM 0.78461182710656 0.20958631756224 no 699 0.216340596773441 243 2788239 SGTC_970 1315-0089 19.5 µM 0.783078845736526 0.210028712735672 no 700 0.216790406381261 234 6811083 YLR033W RSC58 SGTC_2083 5306046 65.942 µM 0.782466855967888 0.210205476829665 no 701 0.216970128227534 243 539837 SGTC_2258 7960471 200 µM 0.782431515279183 0.210215687126978 no 702 0.216980509288213 246 2974708 SGTC_156 3474-0145 5.642 µM 0.782224811413098 0.210275411885392 no 703 0.217041232738773 232 2265471 SGTC_3107 9121808 49.47 µM 0.781431913159199 0.210504603323766 no 704 0.217274253737007 211 662681 SGTC_953 1188-0045 9.7 µM 0.781409642795169 0.210511042806539 no 705 0.217280800751073 239 6144426 SGTC_3224 9130643 49.47 µM 0.779821896824255 0.210970437924636 no 706 0.217747857886941 251 17644395 SGTC_838 0109-0203 71.4 µM 0.779127150272038 0.211171639163693 no 707 0.217952409084398 228 759422 SGTC_3181 9108277 49.47 µM 0.77862487426482 0.211317170208195 no 708 0.218100360999822 251 17097298 SGTC_2243 6634756 200 µM 0.777813580742706 0.211552361016853 no 709 0.218339460261788 208 885676 SGTC_2519 cryptotanshinone 88.04 µM 0.776872555088828 0.211825352541345 no 710 0.218616982406606 238 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_810 3825-7150 143 µM 0.775865201322749 0.21211781414197 no 711 0.218914290594487 212 22330411 YGL099W LSG1 SGTC_3045 9092950 49.47 µM 0.77570289714953 0.212164957436074 no 712 0.218962214440424 250 44120432 SGTC_768 0384-0033 77.3 µM 0.775358182952496 0.212265104340158 no 713 0.219064018839372 233 3965305 YMR134W ERG29 SGTC_1121 fusaric acid 630.51 nM 0.775041904084519 0.212357014468528 no 714 0.219157449375345 217 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1921 5740136 50 µM 0.774511629090343 0.212511163695686 no 715 0.219314146950063 233 1774243 SGTC_2074 5212007 75.395 µM 0.773888989249664 0.212692246492236 no 716 0.219498220728634 242 758611 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.773518499061869 0.212800039163875 no 717 0.21960779248932 250 75037 A free radical scavenger. SGTC_2275 7947463 200 µM 0.77063065655785 0.21364133804032 no 718 0.220462942336553 251 1225414 SGTC_3079 9117512 49.47 µM 0.770125554096286 0.213788685537156 no 719 0.220612709456319 300 7185044 SGTC_2664 lyso-paf C-16 73.48 µM 0.769907128289736 0.213852422610134 no 720 0.220677492589683 260 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2194 5927483 104.545 µM 0.769861385071225 0.213865771970905 no 721 0.220691060997473 217 760979 SGTC_386 1509-0011 3.07 µM 0.769445713325679 0.213987100758462 no 722 0.220814379942292 233 3107280 SGTC_3279 9140807 49.47 µM 0.768862328674093 0.214157450165066 no 723 0.220987521455496 260 45595718 SGTC_2394 5221648 200 µM 0.76672763227113 0.214781457743601 no 724 0.221621735519839 253 788586 SGTC_2987 9018338 71.43 µM 0.763599816982203 0.215697675929163 no 725 0.222552879190618 264 5055682 SGTC_1861 st057647 17.4 µM 0.763047034395458 0.21585983556551 no 726 0.222717672976088 243 688668 SGTC_1645 Cervolide 78 µM 0.76178420710019 0.21623055286486 no 727 0.223094403831426 257 23173 A fragrance. SGTC_2457 5731572 11.68 µM 0.761395114308507 0.216344849718578 no 728 0.223210552374157 253 2865357 SGTC_3289 9119912 71.43 µM 0.759828711020026 0.216805337724042 no 729 0.2236784893192 264 17014829 SGTC_616 4092-0450 108 µM 0.759274909658466 0.216968278606958 no 730 0.223844061635257 274 787165 SGTC_712 r015-0009 80.6 µM 0.757192708641481 0.217581542193299 no 731 0.224467208936725 251 6813872 YLR060W FRS1 SGTC_3088 9117578 49.47 µM 0.756966363302613 0.217648267146679 no 732 0.224535007339385 257 678341 SGTC_237 nikkomycin 200 µM 0.756456593917617 0.217798586673012 no 733 0.224687743771259 251 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1451 4152-0210 104 µM 0.754926456320277 0.218250149316612 no 734 0.225146555306725 254 659563 SGTC_721 1187-1332 279 µM 0.752075388115883 0.219092972414808 no 735 0.226002861926014 259 25730 SGTC_391 gliotoxin 8.33 µM 0.751034658677388 0.219401094968949 no 736 0.226315898833854 257 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3154 9100113 49.47 µM 0.750904264555003 0.219439717522863 no 737 0.226355136826402 245 25237525 SGTC_1873 rapamycin 2 nM 0.750609487932832 0.219527044335109 no 738 0.22644385470026 239 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2961 9083290 32.55 µM 0.750557100959386 0.219542565929305 no 739 0.226459623476349 253 17741490 SGTC_1169 aniline yellow 25.8 µM 0.750501158954815 0.21955914152998 no 740 0.226476463021539 264 6051 A DNA damaging agent. SGTC_552 k242-0005 476 µM 0.749077766454499 0.219981134092921 no 741 0.226905167447049 275 4088318 SGTC_543 3844-1095 191 µM 0.748843712611534 0.220050568460613 no 742 0.226975704740716 273 4230703 SGTC_789 1309-1135 70.6 µM 0.744431783433793 0.221361760673377 no 743 0.228307648293684 245 3092424 SGTC_605 1315-0399 119 µM 0.743908841668507 0.221517470650851 no 744 0.228465812985764 267 24020461 SGTC_573 3702-0553 84.7 µM 0.743854911398653 0.221533532368687 no 745 0.228482127795315 247 1222756 SGTC_814 3342-0569 96 µM 0.74309404494749 0.221760207440743 no 746 0.228712372380414 253 4346283 SGTC_3080 9117754 49.47 µM 0.742899828147128 0.221818089153148 no 747 0.228771164880956 253 9550191 SGTC_941 3237-0776 460 µM 0.742378366945537 0.221973540982764 no 748 0.228929061407164 252 760008 SGTC_1147 3809-1045 12.3 µM 0.742377734274539 0.221973729624912 no 749 0.228929253014743 241 325925 SGTC_1291 0993-0025 5.79 µM 0.741565737608028 0.22221591636037 no 750 0.229175244435622 241 4353356 SGTC_936 3005-4620 401 µM 0.74070428982415 0.222473017185554 no 751 0.229436378868184 255 777207 SGTC_2889 9059656 51.95 µM 0.739607619454188 0.222800565974343 no 752 0.229769058499073 271 3949838 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.739249472227417 0.222907595343167 no 753 0.229877762470268 235 6857784 SGTC_1272 0839-0021 27 µM 0.739170941172397 0.222931067621203 no 754 0.229901601872167 262 5027250 SGTC_45 0kpi-0036 14.9 µM 0.73855872329156 0.223114102710306 no 755 0.230087498187371 256 2795021 SGTC_1032 k061-1018 98.7 µM 0.737637206902844 0.223389770193405 no 756 0.230367469658576 246 4005393 SGTC_1148 3909-7663 27.7 µM 0.736933195039064 0.223600502695897 no 757 0.230581488045505 264 4084526 SGTC_587 k089-0003 57 µM 0.735221354190665 0.2241133809276 no 758 0.23110234795806 262 9659696 SGTC_3315 9136395 68.55 µM 0.733245042214423 0.224706326485878 no 759 0.231704493960982 287 16876844 SGTC_2049 5262831 67.185 µM 0.732942154523607 0.224797279319905 no 760 0.23179685548013 261 763417 SGTC_2075 5212009 200 µM 0.73176404499323 0.22515124716331 no 761 0.232156299068687 266 780898 SGTC_984 1492-0255 2.91 µM 0.730799467723369 0.225441293305633 no 762 0.23245082436294 260 1585198 SGTC_3064 1327-0027 10 µM 0.730272369494109 0.22559987985056 no 763 0.232611856993972 245 16000455 YPR107C YTH1 SGTC_3049 9092223 49.47 µM 0.730077318488857 0.225658580290251 no 764 0.232671462318298 257 8623917 SGTC_1800 st050079 29.0735 µM 0.729386135464136 0.225866660808527 no 765 0.232882748160454 261 3645560 SGTC_82 0054-0107 293.755 µM 0.727190676528109 0.226528322501968 no 766 0.233554578446068 249 3104697 SGTC_3077 9117319 49.47 µM 0.726982241243212 0.226591197012283 no 767 0.233618417345624 288 17154678 SGTC_2627 acetyl isogambogic acid 100 µM 0.726878808870201 0.226622401047559 no 768 0.233650099877078 268 6857789 A caspase activator and apoptosis inducer. SGTC_1924 st058459 75.1 µM 0.725484146257099 0.227043387142861 no 769 0.234077533697305 259 688683 SGTC_2747 doxorubicin 7.63 µM 0.72521920467747 0.227123410934007 no 770 0.234158781460125 210 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1713 st033146 12.748 µM 0.72521737874243 0.227123962500354 no 771 0.2341593414609 271 674619 SGTC_3143 9086658 49.47 µM 0.724665549293477 0.227290690074016 no 772 0.234328617445326 266 25236626 SGTC_497 capsazepine 133 µM 0.722111405307354 0.228063286764529 no 773 0.235112993294072 257 2733484 A calcium channel blocker. SGTC_1526 st051518 75 µM 0.722064914433139 0.228077363346951 no 774 0.235127284035162 258 673993 SGTC_1944 st076371 56.9 µM 0.721505612128431 0.228246748099951 no 775 0.235299244500882 268 24208455 SGTC_1182 1222-0449 220 µM 0.72061509341863 0.228516587642585 no 776 0.235573182430837 266 658318 SGTC_2883 9059145 45.46 µM 0.718203313526694 0.229248289609052 no 777 0.236315967588085 282 16476510 SGTC_1983 st071813 46.9 µM 0.716586485224103 0.229739548451601 no 778 0.236814642978747 258 11838595 SGTC_1448 4255-0083 152 µM 0.716038676337567 0.229906128905445 no 779 0.236983733818346 275 5399660 SGTC_223 busulfan 5 mM 0.71584009042934 0.229966532590773 no 780 0.23704504723325 261 2478 A DNA alkylator. SGTC_2203 7227154 166.4 µM 0.714910470820017 0.230249412176109 no 781 0.237332183251132 253 896304 SGTC_282 k297-0036 65.7 µM 0.710256057779818 0.231668654379938 no 782 0.238772681959169 274 5061378 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.710230348791861 0.231676507181647 no 783 0.238780651918735 289 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1820 st053765 18.6 µM 0.71004604405562 0.231732807344318 no 784 0.238837791890346 264 3690829 SGTC_2301 7769476 200 µM 0.710008590498112 0.231744249335311 no 785 0.238849404525818 269 977820 SGTC_1189 1431-2119 7.28 µM 0.709272087492597 0.231969313554088 no 786 0.239077823161536 278 3107275 SGTC_1236 0330-0013 258 µM 0.707529622976613 0.232502268742414 no 787 0.239618705245937 275 4617066 SGTC_863 0466-0191 129 µM 0.70408811528378 0.233556895875588 no 788 0.240688950463423 284 765160 YPR165W RHO1 SGTC_2759 disulfiram 3.38 µM 0.701885638635343 0.234233219929887 no 789 0.241375242911085 261 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_48 0382-0018 55 µM 0.70154949288362 0.234336536942861 no 790 0.241480079468793 242 762596 SGTC_2048 5246248 200 µM 0.70142941266601 0.234373450645577 no 791 0.24151753587441 256 677046 SGTC_25 0118-0223 35.662 µM 0.70084120690643 0.234554316688545 no 792 0.241701059409538 273 5333628 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.700604784999632 0.23462703526557 no 793 0.241774845707999 261 2333 A French combination drug. SGTC_2680 butyl paraben 22.24 µM 0.700460029860307 0.234671565159781 no 794 0.241820029220838 300 7184 An antifungal and steroid mimetic. SGTC_3185 9108267 49.47 µM 0.700089441945645 0.234785587522774 no 795 0.241935724498052 271 4910486 SGTC_1579 chlormadinone acetate 49.4 µM 0.699692138830607 0.234907863619166 no 796 0.242059793441608 272 45114258 A steroidal progestin. SGTC_2750 bromebric acid 70.15 µM 0.699493300685584 0.23496907230356 no 797 0.242121899132864 263 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_947 3447-0010 211 µM 0.698916739180079 0.235146606026 no 798 0.242302032886655 279 748350 SGTC_2300 7976697 71.57 µM 0.69881995066819 0.235176416220875 no 799 0.242332279411395 255 2236109 SGTC_3019 9081971 49.47 µM 0.695320215984291 0.236255711294554 no 800 0.243427323925859 271 16451803 SGTC_1328 1441-0025 69.2 µM 0.695312599880652 0.236258063021295 no 801 0.24342970986763 268 4562601 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.695135351238294 0.236312798109184 no 802 0.243485241165307 259 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2078 5212016 200 µM 0.695088723788705 0.236327198011504 no 803 0.243499850497402 272 1899708 SGTC_293 4049-0273 38.5 µM 0.694772337485083 0.236424919994332 no 804 0.243598993292954 263 1380311 SGTC_2459 5811157 9.22 µM 0.694280416652939 0.236576903352223 no 805 0.243753184866076 273 2870684 YBR192W RIM2 SGTC_219 mitoxanthrone 164.414 µM 0.694271572498904 0.23657963632487 no 806 0.243755957530013 282 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_802 4112-3352 742 µM 0.691403440278906 0.237466846716766 no 807 0.244656021362603 248 704594 SGTC_2359 9039622 200 µM 0.691386881890013 0.237471974084159 no 808 0.244661222829532 282 6463596 SGTC_1191 1487-1166 10.6 µM 0.687871042311711 0.238562042299331 no 809 0.245766996779049 288 3955771 SGTC_180 1486-1293 102.781 µM 0.687675761028256 0.238622668452766 no 810 0.245828493652689 268 4140536 SGTC_2196 6573537 42.6665 µM 0.686605385526665 0.238955122163435 no 811 0.246165716897935 290 2903087 SGTC_146 3448-8650 53.125 µM 0.685731662084751 0.239226684281363 no 812 0.246441168441033 290 2891488 YIL048W NEO1 SGTC_2977 9011197 71.43 µM 0.68475455906378 0.239530577452402 no 813 0.246749407139584 283 2704722 SGTC_952 1185-0122 232 µM 0.681321752380819 0.240599898987312 no 814 0.247833961142502 267 678600 SGTC_179 1273-0063 6.77 µM 0.680637915108926 0.240813224738872 no 815 0.248050314864926 284 3108139 SGTC_2406 ethylparaben 405.7 µM 0.674830756271956 0.242628931909004 no 816 0.249891648721196 266 8434 A possible steroid mimic. SGTC_3146 9095609 49.47 µM 0.673810837750945 0.242948590352898 no 817 0.25021579185727 283 17173999 SGTC_2876 9059903 25.97 µM 0.672687024775542 0.243301074609528 no 818 0.250573212014553 268 6916095 SGTC_2771 fluoxetine 41.05 µM 0.672677559462716 0.243304044580909 no 819 0.250576223533451 284 3386 A selective serotonin reuptake inhibitor. SGTC_1290 0986-0249 10.2 µM 0.671987223199954 0.243520707139615 no 820 0.250795915156565 290 53329 SGTC_3239 9133757 49.47 µM 0.671601234076625 0.243641895529028 no 821 0.25091879621854 308 17036923 SGTC_1785 bathophenanthroline 24 µM 0.671453971425825 0.243688139929538 no 822 0.250965686223471 266 72812 An iron chelator. SGTC_1754 st042065 16.137 µM 0.671422935865389 0.243697886527954 no 823 0.250975568869832 277 1126236 YIL048W NEO1 SGTC_2662 daunorubicin 22.37 µM 0.670622627863329 0.243949292852729 no 824 0.251230481872612 266 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3067 9117431 49.47 µM 0.670057310018058 0.244126964381011 no 825 0.251410628614856 298 17150885 SGTC_2779 methotrexate 400 µM 0.669944525026099 0.244162419481661 no 826 0.251446577358346 285 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2117 5521686 200 µM 0.669525876997862 0.244294049992829 no 827 0.251580039703844 272 803312 SGTC_1140 3229-1848 2.98 µM 0.668342742381819 0.244666255622769 no 828 0.25195741777599 285 2849525 SGTC_2938 9059746 27.26 µM 0.668108222674993 0.244740070080744 no 829 0.252032256723624 284 6471769 SGTC_419 nsc-638432 893 µM 0.667949302740126 0.24479009652436 no 830 0.252082977254325 268 368090 SGTC_1886 st057356 49.9 µM 0.667149774881682 0.245041863574283 no 831 0.252338234446887 273 24207747 SGTC_2190 6049624 200 µM 0.666345975396514 0.245295116081388 no 832 0.252594992683571 283 2265554 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.665378018526807 0.245600276172952 no 833 0.252904370388275 252 6708630 An antioxidant. SGTC_2706 st078239 82.5 µM 0.66490110958235 0.245750702424011 no 834 0.253056873000039 283 15434492 SGTC_85 0868-0259 160.055 µM 0.663331576694605 0.246246112359177 no 835 0.253559108674797 264 83173 SGTC_1874 staurosporine 7.6 µM 0.660600013983695 0.247109582605267 no 836 0.254434430029125 283 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1320 1313-0481 95.3 µM 0.657613557727906 0.248055477025424 no 837 0.255393240231983 276 6813365 YLR208W SEC13 SGTC_526 4469-0568 170 µM 0.657386595009051 0.248127441376997 no 838 0.255466184380554 287 2901964 SGTC_1819 st053448 58.6 µM 0.657280275888354 0.24816115641108 no 839 0.255500358307655 316 2857616 SGTC_555 4296-0685 37 µM 0.653829955496918 0.249256618282442 no 840 0.256610682483387 303 2908540 YHR072W ERG7 SGTC_3012 9080433 71.4286 µM 0.652457783079349 0.249692990676139 no 841 0.257052949333852 297 17688859 SGTC_1749 st037932 54.2 µM 0.651971539798118 0.249847720984951 no 842 0.257209766182641 315 594497 SGTC_1198 1612-1005 86.7 µM 0.651670903034906 0.249943413820172 no 843 0.257306748511148 296 6998509 SGTC_1607 st000305 50.6 µM 0.651494163209073 0.249999679274407 no 844 0.257363771831204 301 5457690 SGTC_639 0833-0042 114 µM 0.651457849726016 0.25001124057195 no 845 0.257375488823014 307 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.651237230929691 0.250081486131928 no 846 0.257446680147589 296 165506 SGTC_3356 9151811 4.48 µM 0.649450038346293 0.250650918340669 no 847 0.258023764961509 299 1859254 YPR165W RHO1 SGTC_3327 9140648 26.9345 µM 0.648933725767971 0.250815552728806 no 848 0.258190607213063 307 8029710 SGTC_623 k072-0108 16.9 µM 0.648574033392352 0.250930280126761 no 849 0.258306871951596 290 5382803 SGTC_1401 3807-4679 7.6 µM 0.648385006256326 0.250990583310371 no 850 0.258367982787881 300 3291456 SGTC_1792 st045773 43.6 µM 0.648237622586795 0.251037606771155 no 851 0.258415635848988 248 2919270 SGTC_2767 sibutramine 71.45 µM 0.646991963361823 0.251435226382689 no 852 0.258818572411306 288 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2716 st080858 38.6235 µM 0.64631180500674 0.251652476168061 no 853 0.25903872211188 279 5296050 SGTC_3163 9099914 49.47 µM 0.645656991295361 0.251861724241736 no 854 0.259250759860878 317 16268368 SGTC_406 estrone 100 µM 0.64410809062294 0.252357046346337 no 855 0.259752672147846 288 5870 A steroid. SGTC_357 1325-0123 420 µM 0.642632005774535 0.252829560136411 no 856 0.260231455112121 301 1098503 SGTC_2625 euphol 100 µM 0.642528526520086 0.252862702641156 no 857 0.260265036699423 283 6708538 A triterpene alcohol. SGTC_1568 digitonin 820 nM 0.640660958754878 0.253461243160399 no 858 0.260871492395584 313 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2517 totarol 10 µM 0.640567979605208 0.253491061677295 no 859 0.260901704519212 270 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2321 7390090 138.78 µM 0.64010605412427 0.253639229015589 no 860 0.261051826669111 299 649046 SGTC_3160 9100216 49.47 µM 0.640028741262963 0.253664032352229 no 861 0.261076957078778 285 17191039 SGTC_2244 6635614 200 µM 0.639891342466227 0.253708115465652 no 862 0.261121621384866 299 836499 SGTC_3298 9116858 71.43 µM 0.639335316044847 0.253886552393891 no 863 0.261302409311324 320 2506942 SGTC_2809 7964133 12.99 µM 0.638161822030306 0.254263359705801 no 864 0.261684173259298 307 1253665 SGTC_2364 9055074 200 µM 0.63739665843031 0.254509210511931 no 865 0.261933252215618 297 6470630 SGTC_1546 5-methoxyflavanone 78.7 µM 0.635806371393733 0.255020575658081 no 866 0.262451317084956 272 147795 SGTC_1859 st055998 20 µM 0.635178415311778 0.255222646164417 no 867 0.262656029552416 299 676301 SGTC_1735 st034310 56.75 µM 0.634915917602881 0.255307140324565 no 868 0.26274162750524 269 871153 SGTC_2284 7945075 39.21 µM 0.634415537746496 0.255468245751119 no 869 0.262904836032312 305 1245402 SGTC_1396 3511-0007 98.6 µM 0.633296433530288 0.255828751694564 no 870 0.26327004093293 283 X1396 SGTC_120 rhodamine 6G 52.259 µM 0.633257909867622 0.25584116635444 no 871 0.263282617233628 313 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3132 9126706 49.47 µM 0.63183097022774 0.256301234261368 no 872 0.263748667035579 316 850858 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.628622982138369 0.257337112721627 no 873 0.264797955377481 292 16486 A toxic proline analog. SGTC_2071 5230951 39.92 µM 0.625648176863905 0.258299635729423 no 874 0.265772865795113 306 1799272 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.625522174614033 0.258340445954328 no 875 0.265814199688365 290 140250 A respiratory chain inhibitor. SGTC_1941 st076221 61.8 µM 0.624162583667126 0.258781009355434 no 876 0.266260408299045 280 2828568 SGTC_2338 7999974 200 µM 0.624007214194082 0.258831380200913 no 877 0.266311423643703 313 315925 SGTC_844 0330-0132 15.3 µM 0.623379748923763 0.259034856297742 no 878 0.266517501285699 301 2828079 SGTC_3108 9121785 49.47 µM 0.621354874191565 0.259692051781731 no 879 0.267183078026287 285 17140271 SGTC_175 3793-3120 23.7 µM 0.620745411835654 0.259890027893163 no 880 0.267383572563787 316 5322297 SGTC_2605 digitonin 300 nM 0.620064499213212 0.260111305762669 no 881 0.267607661787051 295 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_409 arachidonic acid 100 µM 0.61997767284792 0.260139528923077 no 882 0.267636243260208 295 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2154 5570129 200 µM 0.617284050408101 0.261015882107617 no 883 0.268523692572937 322 673366 SGTC_2852 9023854 51.95 µM 0.617152415023486 0.261058747723905 no 884 0.268567099461699 321 19798528 SGTC_2337 9009472 200 µM 0.615514060823946 0.261592562419972 no 885 0.26910764319551 309 5742383 SGTC_3308 9128332 17.569 µM 0.614754502942332 0.261840234355773 no 886 0.269358429923528 273 17332805 YDL196W YDL196W SGTC_1973 st070275 50.2 µM 0.614382711576922 0.261961509612912 no 887 0.269481228697038 280 17118334 SGTC_1496 4469-0713 57.4 µM 0.613849011937781 0.262135648333671 no 888 0.269657553104177 313 746691 SGTC_3335 9143315 29.6265 µM 0.612197042969679 0.262675038410431 no 889 0.270203698891136 285 4899691 SGTC_2722 naftopidil 47.16 µM 0.611924474430473 0.262764090248075 no 890 0.270293863986353 314 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1027 k015-0025 8.67 µM 0.610793478078232 0.263133766996445 no 891 0.270668155815639 297 3598955 SGTC_524 r073-0010 27.8 µM 0.610335340114141 0.263283589265928 no 892 0.270819845575707 318 2772106 SGTC_479 n-linoleoylglycine 10 µM 0.609340033346206 0.263609228880844 no 893 0.271149538417285 310 6433346 An anti-infammatory. SGTC_499 genistein 192 µM 0.609219877482265 0.263648554787252 no 894 0.27118935327693 324 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2894 9048625 32.47 µM 0.609045010967721 0.263705792332006 no 895 0.271247302270796 320 4092861 SGTC_2673 kobusone 100 µM 0.608842969007577 0.263771932871713 no 896 0.27131426461761 321 6710676 An epoxy ketone and protein crosslinker. SGTC_471 1-acyl-paf 4 µM 0.608458757184687 0.263897731948694 no 897 0.271441625869165 283 16759367 SGTC_3103 9120822 49.47 µM 0.606249651015388 0.264621633022952 no 898 0.272174493454692 324 17141819 SGTC_680 0417-1641 114 µM 0.606153550379099 0.264653147110903 no 899 0.27220639700228 291 2835990 SGTC_1738 st035555 74 µM 0.60439535098932 0.265230046625603 no 900 0.272790412952923 320 5331140 SGTC_2546 rhodinyl acetate 100 µM 0.604143631210754 0.26531269301515 no 901 0.272874076815523 289 6708682 SGTC_1734 st037168 69.4 µM 0.602582726656297 0.265825471754696 no 902 0.273393157127137 302 708907 SGTC_1073 triclabendazole 3.09 µM 0.601688824176557 0.266119357116613 no 903 0.27369064527519 296 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1327 1436-0082 2.18 µM 0.601611607866486 0.266144750985145 no 904 0.273716350150649 300 15992205 SGTC_2972 9093619 59.92 µM 0.600249205440592 0.266593001403895 no 905 0.274170082574953 269 25236256 SGTC_188 3229-0966 278.469 µM 0.597858231469212 0.267380588750224 no 906 0.274967265936176 310 5722370 SGTC_1184 1269-1718 139 µM 0.596803505004311 0.267728388575674 no 907 0.275319288787218 296 5403821 SGTC_1912 st060209 90.8 µM 0.596730593119812 0.267752439952219 no 908 0.275343631868226 324 688787 SGTC_205 1486-1330 71.903 µM 0.594847178706201 0.268374097179639 no 909 0.275972813991653 308 4118834 SGTC_2404 5161160 200 µM 0.594046415692434 0.268638624189674 no 910 0.276240534348863 314 2831543 SGTC_1962 st076595 64.5 µM 0.593450433674381 0.268835588100628 no 911 0.27643987264398 310 279619 SGTC_221 trifluoperazine 10.304 µM 0.591631874639864 0.269437044942927 no 912 0.277048562332323 312 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1391 3442-0225 151 µM 0.59122683542285 0.269571096425328 no 913 0.277184222231987 309 5227075 SGTC_893 0958-0369 48.9 µM 0.590946408199395 0.269663925987771 no 914 0.277278164836528 313 6819948 SGTC_550 4123-0385 25.7 µM 0.590701649328561 0.269744961374181 no 915 0.277360171333371 303 5731123 SGTC_1154 4088-0362 150 µM 0.589397191821474 0.270177050061203 no 916 0.27779742993734 303 6618304 SGTC_2581 avocatin a 64 µM 0.587880832931867 0.270679763694382 no 917 0.27830614127215 323 6710728 A skin care supplement. SGTC_2909 7941780 10.49 µM 0.587313998908837 0.270867804239289 no 918 0.278496420502926 302 1243215 SGTC_1050 3232-1156 69.3 µM 0.585654381581615 0.27141873744707 no 919 0.27905389784908 304 700529 SGTC_15 0266-0086 27.098 µM 0.584202704285025 0.271901099365163 no 920 0.279541971164955 316 1712902 YIL048W NEO1 SGTC_2104 5389443 200 µM 0.58343451567765 0.27215652475835 no 921 0.279800414031777 319 2244536 SGTC_2851 9015922 71.43 µM 0.582792993518135 0.272369924470113 no 922 0.280016331092718 320 2996893 SGTC_111 0083-0039 52.457 µM 0.582651416811363 0.272417030573601 no 923 0.280063992430929 306 759313 SGTC_1508 1080-0625 72.9 µM 0.581984085589578 0.272639122796948 no 924 0.280288700250784 309 767111 SGTC_607 4491-0986 66.8 µM 0.581899039663457 0.272667433095846 no 925 0.280317343703579 292 698981 YDR232W HEM1 SGTC_1510 1123-0200 71.5 µM 0.580676420775291 0.273074582675192 no 926 0.280729278130844 324 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3309 9129340 25.759 µM 0.580435395741001 0.273154883002891 no 927 0.280810520726665 295 17158987 SGTC_510 ag-490 170 µM 0.580320760236821 0.273193079276271 no 928 0.280849165041691 298 5328779 SGTC_140 0062-0056 502.533 µM 0.57905231428383 0.273615898966809 no 929 0.281276937302329 295 3758964 SGTC_1345 1488-0192 31.4 µM 0.578782149823665 0.27370599652777 no 930 0.281368088511729 319 658348 SGTC_798 1287-0182 476 µM 0.576702685487871 0.274399971093562 no 931 0.28207015899664 337 1649755 SGTC_955 1216-0110 33 µM 0.576306445570672 0.274532305720903 no 932 0.282204033468629 324 3619719 SGTC_2037 5169046 200 µM 0.575236555636768 0.274889780511538 no 933 0.282565661476572 289 5718022 SGTC_2529 gangaleoidin 93.61 µM 0.570905492139485 0.276339227906055 no 934 0.284031853919959 327 4565183 SGTC_1386 3228-0095 33.8 µM 0.569410078599604 0.276840557025186 no 935 0.284538939363293 324 870181 SGTC_1684 st024538 14.6195 µM 0.56855956086072 0.277125886977662 no 936 0.284827537402596 306 6732859 SGTC_2061 5245884 80.95 µM 0.568288860737301 0.27721673108095 no 937 0.284919420774446 336 573863 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.567784456222276 0.277386042762213 no 938 0.285090667814435 313 97141 SGTC_226 1,3-diallylurea 8.28947 mM 0.567408826259943 0.277512161980107 no 939 0.28521822732501 309 74537 YKL182W FAS1 SGTC_799 1310-0557 151 µM 0.56554501964754 0.27813835646239 no 940 0.285851556023024 337 5354492 SGTC_1561 5-methoxyflavone 52.9 µM 0.564249623673116 0.278573984117107 no 941 0.286292130112964 307 94525 SGTC_2062 5245942 200 µM 0.563969338094338 0.278668284836816 no 942 0.286387499793987 317 1376160 SGTC_484 loperamide 105 µM 0.563873672399374 0.278700474652051 no 943 0.286420054355724 291 3955 An opioid-receptor agonist. SGTC_1221 2958-7315 257 µM 0.56334078766772 0.278879814063416 no 944 0.286601424518536 310 4562705 SGTC_1703 st026983 48.3 µM 0.563054004916306 0.278976352448754 no 945 0.286699055099732 308 1104023 SGTC_1828 st055811 49 µM 0.562184538225208 0.279269136411825 no 946 0.286995147405004 331 5877589 SGTC_876 0720-0963 56.8 µM 0.559589168053612 0.280143987676034 no 947 0.287879847469026 347 765861 SGTC_1818 st052136 56.3 µM 0.559177143416012 0.280282995611305 no 948 0.288020415257412 304 674169 SGTC_2132 5317594 122.667 µM 0.55855152592122 0.280494128874082 no 949 0.288233915066178 341 794577 SGTC_982 1491-0518 27.5 µM 0.558391371748287 0.280548190044273 no 950 0.288288581682521 319 3091256 SGTC_756 0508-1999 28.3 µM 0.558048886857935 0.280663815151736 no 951 0.288405501005296 334 6753853 SGTC_1560 lithocholic acid 53.1 µM 0.557851743492899 0.280730382475433 no 952 0.28847281299635 315 9903 A bile acid which acts as a detergent. SGTC_3055 9094636 49.47 µM 0.557358749261305 0.280896880060588 no 953 0.288641171747776 312 25236176 SGTC_3133 9127736 49.47 µM 0.555719491791804 0.2814508449537 no 954 0.289201314770567 320 27243420 SGTC_3259 9138485 49.47 µM 0.554472863834906 0.281872478574898 no 955 0.289627635986151 297 17646153 SGTC_2079 5212404 121 µM 0.554190292408742 0.281968091976151 no 956 0.289724310621914 295 758462 SGTC_3299 9121982 43.1275 µM 0.55407837411856 0.282005965970957 no 957 0.289762604808174 316 17594604 YPL160W CDC60 SGTC_599 1935-0052 86.5 µM 0.55219150715329 0.282644864592152 no 958 0.290408576236878 297 9557311 SGTC_1389 3405-0187 19 µM 0.551528212693934 0.28286962316024 no 959 0.290635816031728 300 799890 SGTC_64 000l-0018 272.079 µM 0.551113307733134 0.28301025810681 no 960 0.290778001689874 312 6811119 SGTC_745 0469-0705 296 µM 0.551048625332321 0.283032185683981 no 961 0.290800170924569 342 3486736 SGTC_986 1493-0483 84 µM 0.55002438185461 0.283379516727329 no 962 0.291151325237199 339 40079 SGTC_1248 0469-0687 58.6 µM 0.547813167103735 0.284130057461671 no 963 0.291910098285434 321 4017482 SGTC_548 1436-0017 110 µM 0.547627957815886 0.284192965178255 no 964 0.29197369418715 330 9677137 SGTC_842 0271-0008 11.1 µM 0.546941566879902 0.284426161037831 no 965 0.292209438663337 301 1221709 SGTC_2003 4023581 200 µM 0.54528420737766 0.284989612321464 no 966 0.292779032020268 328 16641307 SGTC_1210 3013-0140 750 nM 0.545164588681164 0.285030299587784 no 967 0.292820161938689 317 905973 SGTC_1434 4073-0095 163 µM 0.545052322997304 0.285068488309762 no 968 0.292858766023368 320 24133745 SGTC_1755 st041960 45.185 µM 0.544892369055472 0.285122903064244 no 969 0.292913772445658 344 2257073 SGTC_2287 7945887 168.79 µM 0.541287245327354 0.286350642008566 no 970 0.294154805209511 329 1245853 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.539004226220046 0.287129428661028 no 971 0.294941969215763 323 4213774 SGTC_950 1165-0508 94.1 µM 0.536486000622676 0.287989610595306 no 972 0.295811354315573 334 6148369 SGTC_1094 duloxetine 25.4 µM 0.536085383440369 0.288126566514222 no 973 0.295949770725368 300 60834 A selective serotonin reuptake inhibitor. SGTC_1018 4259-0013 28.1 µM 0.535463435975055 0.288339247785673 no 974 0.296164717400456 328 6801262 SGTC_1093 fluphenazine 7.97 µM 0.533468661238594 0.28902188028265 no 975 0.296854599545484 336 6602611 An atypical antipsychotic. SGTC_1920 st075728 45.7 µM 0.53340235128217 0.289044585283718 no 976 0.296877545113549 357 3400306 SGTC_1194 1488-0194 225 µM 0.532814067395105 0.289246054603171 no 977 0.297081147479982 330 1391452 SGTC_3214 9129694 49.47 µM 0.530054750954278 0.290191916242611 no 978 0.298036985281709 359 17158655 SGTC_2487 5918373 44.05 µM 0.529998937905432 0.290211063251268 no 979 0.298056333588884 333 2876279 SGTC_509 pifithrin 175 µM 0.52654306957572 0.291397771265865 no 980 0.299255467712298 348 4817 A p53 inhibitor. SGTC_1554 st069299 38.7 µM 0.526205478855234 0.291513817570163 no 981 0.299372723855584 296 24207999 SGTC_698 k064-0052 127 µM 0.526163552003049 0.291528231367263 no 982 0.299387287857762 344 5088751 SGTC_2772 vinpocetine 57.06 µM 0.525192768403201 0.291862064511713 no 983 0.299724595788629 374 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2251 lansoprazole 556 µM 0.524803322411009 0.291996037259868 no 984 0.299859960836147 342 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1113 artemisinin 1.17947 µM 0.52429771623086 0.292170012809176 no 985 0.300035742539188 333 2240 An anti-malaria and mitochondrial poison. SGTC_2430 5571206 200 µM 0.523571287439769 0.292420056270593 no 986 0.300288378163765 337 1731771 SGTC_1087 pterostilbene 9.05 µM 0.522700676640269 0.292719859499252 no 987 0.300591283655899 344 5281727 Similar to reservatol, lowers cholesterol. SGTC_3031 9088762 49.47 µM 0.520541328100523 0.293464067428705 no 988 0.30134316531514 322 205253 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.519504276365074 0.293821793019047 no 989 0.301704565783169 367 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_634 1611-4317 11.2 µM 0.519345314365985 0.293876643957925 no 990 0.301759979412551 358 2843522 SGTC_2167 5876490 200 µM 0.517881111150129 0.29438209999846 no 991 0.302270610845031 342 686534 SGTC_51 1013-0126 23.419 µM 0.517675734796109 0.294453029839118 no 992 0.302342265519116 350 1627850 SGTC_744 1594-0068 283 µM 0.517561724356622 0.294492408479459 no 993 0.302382046419627 335 668392 SGTC_560 2332-1943 155 µM 0.51664577426586 0.294808861262174 no 994 0.302701727915436 325 21177716 SGTC_102 gallobenzophenone 83.616 µM 0.516231133529068 0.294952167554926 no 995 0.30284649404982 342 70837 SGTC_2549 cedrol 20.94 µM 0.515082756117845 0.295349232119301 no 996 0.303247596011035 322 6708665 A sedative which affects the nervous system. SGTC_1077 5-fluorocytosine 377 nM 0.514511111607736 0.295546976360805 no 997 0.303447346858564 360 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3110 9122132 49.47 µM 0.513548597095198 0.295880068488105 no 998 0.303783812903301 304 918317 SGTC_1464 k208-0027 110 µM 0.513456056046749 0.295912102744979 no 999 0.303816171232524 350 X1464 SGTC_664 1222-0054 14.9 µM 0.512959153325485 0.29608413914911 no 1000 0.303989946815115 319 6813991 SGTC_2309 7664088 163.95 µM 0.512696167966439 0.296175207846308 no 1001 0.304081935329122 352 704922 SGTC_2640 pentamidine 10.38 µM 0.512389560461728 0.296281398594543 no 1002 0.304189197905524 329 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_594 1487-1584 10.8 µM 0.509090058792589 0.297425254561782 no 1003 0.305344549839912 345 5013332 SGTC_1122 capsaicin 818.572 nM 0.508696131960354 0.297561953960696 no 1004 0.305482617044697 359 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_178 4092-0806 87.505 µM 0.507652607591139 0.297924213443246 no 1005 0.305848495034884 322 2169044 SGTC_367 0335-0881 7.1 µM 0.507232981492007 0.298069943303195 no 1006 0.305995677995233 357 23828853 SGTC_3333 9141820 12.094 µM 0.505550552164168 0.298654551717994 no 1007 0.306586100933567 350 1939433 SGTC_770 0389-1121 67.2 µM 0.503802067813119 0.299262664698704 no 1008 0.307200237232939 326 6753108 SGTC_1742 st038235 28.8875 µM 0.503210256686533 0.299468620441663 no 1009 0.307408227184606 366 564103 YBR002C RER2 SGTC_2299 7976368 114.88 µM 0.503130528454481 0.299496371514267 no 1010 0.307436252129333 339 2979718 SGTC_3228 9131799 49.47 µM 0.502631143336964 0.299670219422557 no 1011 0.30761181451755 342 17015818 SGTC_3068 9116768 49.47 µM 0.50205856778902 0.29986960290736 no 1012 0.307813161755153 352 41904888 SGTC_3074 9116018 49.47 µM 0.501273875834484 0.300142947520808 no 1013 0.308089194134333 361 17027303 SGTC_907 3448-6986 75.5 µM 0.499814045246461 0.300651773811526 no 1014 0.308603009990304 351 590582 SGTC_1747 st037496 66.6 µM 0.498815426785471 0.301000067994579 no 1015 0.308954709314368 333 723305 SGTC_189 3970-0742 2.116 µM 0.498365442077851 0.301157071300761 no 1016 0.309113244862868 363 2891807 SGTC_1196 1588-0294 184 µM 0.497236448760505 0.301551148526847 no 1017 0.309511160565833 355 6144269 SGTC_1225 1216-0074 20.6 µM 0.49358832110897 0.302826117289164 no 1018 0.310798475234574 333 4241466 SGTC_2618 avocadyne 43.43 µM 0.490704920152413 0.3038355294194 no 1019 0.311817583037317 345 3015189 SGTC_883 0850-0245 24.6 µM 0.490537115980784 0.303894319978736 no 1020 0.311876936153725 333 6823229 YPR165W RHO1 SGTC_546 peri-Naphthalide 147 µM 0.490365483037788 0.303954457204331 no 1021 0.311937648578668 320 223824 A penicillin ester. SGTC_2566 crystal violet carbinol 226 nM 0.488783581017547 0.304508978051335 no 1022 0.312497461684598 362 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1463 k081-0032 34.1 µM 0.488471956934472 0.304618267987716 no 1023 0.312607792196539 327 977755 SGTC_3139 9095020 49.47 µM 0.488176190926078 0.304722012459889 no 1024 0.312712523692426 312 25236292 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.48664872298493 0.305258045170383 no 1025 0.313253644546531 362 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1656 st012921 11 µM 0.485793062153673 0.305558504033323 no 1026 0.31355694688895 339 6732821 SGTC_1784 st039334 36.3 µM 0.485720255129257 0.305584075721922 no 1027 0.313582760299372 360 3496984 SGTC_1138 3761-0006 1.03 µM 0.485236553056182 0.30575398833203 no 1028 0.313754277916415 336 12061087 SGTC_2669 eugenol 100 µM 0.484029551458672 0.306178160576798 no 1029 0.314182448367849 342 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1097 itavastatin 7.23 µM 0.483266891273973 0.306446313580659 no 1030 0.314453122656713 347 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.481682110534634 0.307003857431187 no 1031 0.315015893156184 332 165521 SGTC_586 0957-0265 8.15 µM 0.48121036057086 0.307169910738821 no 1032 0.315183499045788 357 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1640 st009078 66.4 µM 0.480616001689535 0.307379177991462 no 1033 0.315394720266961 357 690618 SGTC_3237 9133362 49.47 µM 0.47841360371989 0.308155164612652 no 1034 0.316177926555207 368 43845137 SGTC_212 3807-4682 38.772 µM 0.476581369208367 0.308801383168024 no 1035 0.316830126370099 342 3125501 YBL034C STU1 SGTC_1263 0774-1208 64.8 µM 0.476427289298472 0.308855753295197 no 1036 0.31688499844918 375 906585 SGTC_588 3970-1144 52.9 µM 0.475447674083223 0.30920152773625 no 1037 0.317233960454741 347 1888707 SGTC_1989 st071868 50.2 µM 0.475399599414785 0.309218500989698 no 1038 0.317251089970515 362 16414057 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.474085517315379 0.309682608694608 no 1039 0.317719462901802 332 688803 SGTC_2757 clomiphene 4.22 µM 0.473319806222547 0.309953182692289 no 1040 0.317992516819703 381 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3321 9137793 26.8275 µM 0.472584983484624 0.310212938712057 no 1041 0.318254648968851 352 4904192 SGTC_408 cantharidin 100 µM 0.470335403487192 0.311008741975007 no 1042 0.319057703608278 335 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3325 9138760 55.175 µM 0.470069334072992 0.311102924293427 no 1043 0.319152741299353 319 43844959 SGTC_1106 tegaserod maleate 11.7 µM 0.467606517367533 0.311975290083454 no 1044 0.320033001675289 366 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_109 0132-0036 33.701 µM 0.467263846453558 0.312096752917748 no 1045 0.320155559651163 338 67274 A color developer. SGTC_469 w7 172 µM 0.466892799310633 0.312228297004046 no 1046 0.320288288657979 354 45115570 A P450 inhibitor. SGTC_794 k038-0031 316 µM 0.465497456439466 0.312723189849359 no 1047 0.320787628996561 350 6624242 SGTC_3323 9138564 53.9225 µM 0.464459700070711 0.313091474903122 no 1048 0.321159213095974 337 43912313 YNL103W MET4 SGTC_589 1227-0070 34.1 µM 0.463343681779859 0.313487742194942 no 1049 0.321559019951419 350 2841384 SGTC_2997 9067075 71.4286 µM 0.463259717901645 0.313517564167161 no 1050 0.321589107876137 387 27209819 SGTC_2413 inermin 26.06 µM 0.46285964597581 0.313659676937321 no 1051 0.321732487191377 389 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_773 4358-1457 44.6 µM 0.461726423051108 0.314062368243982 no 1052 0.322138760049273 373 1186886 SGTC_1913 st060213 96.1 µM 0.461526160033671 0.314133554845586 no 1053 0.322210578659564 387 688959 SGTC_1042 0350-0096 82 µM 0.461360734036018 0.31419236330293 no 1054 0.322269908974545 354 3122515 SGTC_1326 1431-2094 10.8 µM 0.460611250630724 0.314458861543431 no 1055 0.322538769185341 377 616278 SGTC_281 1672-3440 14.9 µM 0.460511985672963 0.314494165026548 no 1056 0.322574385206905 356 6833000 SGTC_396 dithiazanine 1.25 µM 0.460249932799686 0.314587372018912 no 1057 0.322668416952141 331 10578 An antihelmenthic. SGTC_989 1501-0895 10.3 µM 0.459914724464814 0.314706616178977 no 1058 0.322788715412218 368 2830112 SGTC_2153 5569715 200 µM 0.458829921816792 0.315092647060178 no 1059 0.323178152885105 382 2054701 SGTC_1017 4239-0030 168 µM 0.458417265029541 0.315239545513746 no 1060 0.323326345056198 330 1149593 SGTC_1417 3966-0327 90.4 µM 0.457367217740825 0.31561347533692 no 1061 0.323703561542603 361 651118 SGTC_2491 paeonol 100 µM 0.456769158391981 0.315826533258353 no 1062 0.323918487972989 362 11092 Increases levels of cortical cytochrome oxidase. SGTC_1281 0884-0031 11.8 µM 0.456764270823985 0.31582827470079 no 1063 0.323920244675342 357 1548255 SGTC_2686 alizarin 95.37 µM 0.456123355950774 0.31605666833061 no 1064 0.324150637922885 318 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2740 felodipine 17.08 µM 0.455181587235298 0.316392400307387 no 1065 0.324489302974138 368 3333 L-type calcium channel blocker SGTC_2754 granisetron 64.02 µM 0.454902336643766 0.316491979712952 no 1066 0.324589750898424 381 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2875 9039966 71.43 µM 0.45408687072354 0.316782847034556 no 1067 0.324883151349634 377 6463691 SGTC_1492 4158-0558 28.5 µM 0.453439105682672 0.317013978137456 no 1068 0.325116291334721 337 3967268 SGTC_931 2812-0076 566 µM 0.452677051974159 0.317285980370835 no 1069 0.325390653134626 360 3450959 SGTC_2271 7849410 118.62 µM 0.451413564027072 0.317737178583907 no 1070 0.32584575456641 370 972430 SGTC_3271 9137798 49.47 µM 0.450920903876956 0.317913183542586 no 1071 0.326023278441585 337 6498326 SGTC_2066 5222451 176 µM 0.450910469025882 0.317916911883097 no 1072 0.326027038935305 343 2281147 SGTC_716 1683-5115 658 µM 0.449243533602896 0.31851273959698 no 1073 0.326627993218925 378 723597 SGTC_1515 3460-0031 42.1 µM 0.446980095786942 0.319322532197067 no 1074 0.327444715646286 355 2876596 SGTC_1356 1502-0781 85.8 µM 0.446485381779801 0.319499641574308 no 1075 0.327623334856193 337 567702 SGTC_884 0851-0618 334 µM 0.446265941822142 0.319578215048372 no 1076 0.327702577493448 378 9642473 SGTC_1293 1000-1278 195 µM 0.445873157154259 0.319718877186688 no 1077 0.32784443654685 378 678847 SGTC_1454 4239-0054 42.6 µM 0.445035545120704 0.32001892534216 no 1078 0.32814703348416 375 1340767 SGTC_454 lyso-paf C-16 6.67 µM 0.44087932752834 0.321509498351654 no 1079 0.329650180124535 373 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1126 isoteolin 1.0172 µM 0.439378123316649 0.322048594504621 no 1080 0.330193787699188 348 133323 SGTC_1323 1348-1351 11.2 µM 0.438762958779533 0.32226961400064 no 1081 0.33041665126152 371 6989654 SGTC_1685 st024049 53.0905 µM 0.437971863551074 0.322553935164576 no 1082 0.33070333991695 378 1941139 SGTC_3294 9122953 26.2835 µM 0.43658485005424 0.32305268097912 no 1083 0.331206225850704 366 16459826 SGTC_1564 D-Arginine 115 µM 0.436258728887427 0.323169994704132 no 1084 0.331324511027781 359 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_204 PMA1.184 62.41 µM 0.435902221786528 0.323298259112997 no 1085 0.33145383653398 353 2252213 YGL008C PMA1 SGTC_1233 0325-0408 14.2 µM 0.434898957801834 0.32365932692523 no 1086 0.331817885559642 384 12874 SGTC_2878 9043973 25.97 µM 0.434557276788106 0.323782333498785 no 1087 0.331941905800906 366 6465167 SGTC_1257 0669-0121 16 µM 0.434021506790402 0.323975251662156 no 1088 0.332136411755875 366 4307855 SGTC_1458 k015-0034 6.33 µM 0.431133561888535 0.32501594597156 no 1089 0.333185629273719 365 3598957 SGTC_2165 5727197 32.143 µM 0.430501484248492 0.325243902851956 no 1090 0.333415443625982 385 1361712 SGTC_785 1270-0111 65.3 µM 0.430403316719257 0.325279312543645 no 1091 0.333451141542745 343 6741994 SGTC_3269 9137823 49.47 µM 0.430370072072202 0.325291304470273 no 1092 0.333463231061718 349 17682936 SGTC_749 1000-0129 128 µM 0.429743966849014 0.325517185370164 no 1093 0.333690948459928 377 708470 SGTC_1878 temozolomide 1 mM 0.428658656763593 0.325908886098341 no 1094 0.33408582594874 378 5394 DNA alkylating agent. SGTC_2855 9016525 58.44 µM 0.426848969363064 0.326562450148905 no 1095 0.334744668177304 369 43811474 SGTC_960 1222-0186 7.7 µM 0.426428631313848 0.326714330485033 no 1096 0.334897771100279 375 3126296 SGTC_1501 4491-0275 38.4 µM 0.425290438920051 0.327125736548411 no 1097 0.335312481280052 390 5104718 SGTC_1678 st019265 80.2 µM 0.421722579665475 0.328416719373715 no 1098 0.336613760657696 379 5367020 SGTC_2707 st078556 66.6 µM 0.419985064019366 0.329046160253152 no 1099 0.337248182421565 358 17250899 SGTC_553 k007-0256 45.7 µM 0.418812212833261 0.3294713173669 no 1100 0.337676689297806 357 6287000 SGTC_2414 st077232 92.9 µM 0.417693047420488 0.329877219105988 no 1101 0.338085778124146 323 729801 SGTC_2266 7929956 200 µM 0.415554903156154 0.330653243524196 no 1102 0.338867865999331 363 2967153 SGTC_1239 0337-0584 35.4 µM 0.414572336962068 0.331010103541284 no 1103 0.339227501220691 389 914301 YML130C ERO1 SGTC_1307 1187-1599 12.2 µM 0.413342582569078 0.331456956673687 no 1104 0.339677817767699 368 1538471 SGTC_2305 7443522 69.23 µM 0.411808095307047 0.332014876489766 no 1105 0.340240043682756 380 5415886 SGTC_2442 5158906 48.48 µM 0.409310115465809 0.332923906477528 no 1106 0.341156046538055 361 1893835 SGTC_2070 5230947 200 µM 0.408388932863986 0.333259378738651 no 1107 0.341494078601073 407 2835538 SGTC_2655 perillic acid 100 µM 0.40782111621382 0.33346623022364 no 1108 0.341702504831489 372 5702197 An apoptosis inducer. SGTC_1644 st010134 20.9 µM 0.40755058645341 0.333564800069309 no 1109 0.341801824110345 397 3818134 SGTC_1966 st070145 16.1 µM 0.407444893708048 0.333603313252384 no 1110 0.341840629941336 372 3748532 SGTC_3112 9123419 49.47 µM 0.405765024310473 0.334215672934514 no 1111 0.342457629866209 396 17015854 SGTC_2314 7727897 200 µM 0.403703792993659 0.334967652941336 no 1112 0.343215275032596 341 900724 SGTC_320 4092-0846 5.34 µM 0.403586766790848 0.335010366421448 no 1113 0.34325830920795 369 1359356 SGTC_2471 5466956 24.79 µM 0.401747760765707 0.335681866540267 no 1114 0.343934835550948 370 724419 SGTC_2195 6536160 144.242 µM 0.399833141719921 0.336381534147113 no 1115 0.344639709362304 365 3834386 SGTC_1643 st009866 20.2 µM 0.398715571153844 0.336790195087625 no 1116 0.345051396583044 364 3156273 YOR207C RET1 SGTC_1938 st074717 56.4 µM 0.397455239571366 0.337251290590722 no 1117 0.345515893788567 376 17250979 SGTC_2393 9031399 185.94 µM 0.396910858160131 0.337450529582835 no 1118 0.34571659843246 387 1526623 YDL150W RPC53 SGTC_564 3555-0129 330 µM 0.396442462323043 0.337621994982284 no 1119 0.345889323135805 378 563260 SGTC_3091 9116372 49.47 µM 0.396364302421482 0.337650610216451 no 1120 0.345918148347033 352 17169793 SGTC_3256 9138902 49.47 µM 0.394217315472854 0.338437013216734 no 1121 0.346710301392122 394 17228773 SGTC_906 1165-0455 526 µM 0.392817016205363 0.338950298019225 no 1122 0.347227317883954 383 3252859 SGTC_657 3534-0529 86.7 µM 0.392178229866027 0.339184546895676 no 1123 0.347463264196892 388 1049549 SGTC_854 0422-0053 192 µM 0.390481567350518 0.33980703045753 no 1124 0.348090241408385 380 3596728 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.390395905516525 0.339838470283068 no 1125 0.34812190753806 379 5377381 SGTC_420 mitomycin C 81.9 mM 0.390100231192107 0.339946997988687 no 1126 0.348231215941843 367 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1967 st070177 51.4 µM 0.389974508543328 0.339993148696081 no 1127 0.348277698408106 400 5729214 SGTC_619 1652-1634 108 µM 0.388025439875873 0.340708925964397 no 1128 0.348998603701058 376 5400454 SGTC_2102 5377816 72.7585 µM 0.387640886288199 0.340850217551659 no 1129 0.349140903676051 405 1379702 SGTC_1399 3562-5772 25 µM 0.384881258034636 0.341864806317253 no 1130 0.350162696105456 363 23847490 SGTC_1519 esterone 74 µM 0.384506906747189 0.342002526335736 no 1131 0.350301388892385 365 698 A steroid. SGTC_3313 9133968 57.047 µM 0.384451637712574 0.342022861031092 no 1132 0.350321867117053 391 1494643 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.383514932528368 0.342367565153344 no 1133 0.350669000275668 390 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2511 berberine 10.47 µM 0.38177659127718 0.343007616364914 no 1134 0.351313541706105 368 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_309 k408-0051 1.48 µM 0.381320272888543 0.343175705976833 no 1135 0.351482806216723 388 3640463 SGTC_2705 st078069 42.8 µM 0.380678299796883 0.343412235959825 no 1136 0.351720986436608 376 1530061 SGTC_1609 st001574 46.4 µM 0.380539043558943 0.343463551934658 no 1137 0.351772659966711 428 3960012 SGTC_2350 9023895 38.85 µM 0.380248799350663 0.343570516305648 no 1138 0.351880369097691 382 2997209 SGTC_1901 st060216 58.6 µM 0.380218671296294 0.343581620185185 no 1139 0.351891550248495 366 688792 SGTC_934 2950-0684 338 µM 0.379507275668952 0.343843848616312 no 1140 0.352155601236896 410 1121253 SGTC_2897 9048598 12.99 µM 0.378450728136027 0.344233442561863 no 1141 0.352547894904749 375 6467404 SGTC_478 N-arachidonylglycine 10 µM 0.377774105762922 0.344483028857211 no 1142 0.35279920566784 367 5283389 SGTC_2415 st077333 57.7 µM 0.376534221481809 0.344940561774118 no 1143 0.353259889562465 434 2766255 SGTC_1453 4237-0541 195 µM 0.375999907771354 0.34513780023709 no 1144 0.353458482292297 361 739892 SGTC_1120 ficusin 1.78878 µM 0.375347192187083 0.345378803081426 no 1145 0.353701136550745 391 6199 A DNA cross-linker. SGTC_2867 9039098 71.43 µM 0.374849302864908 0.345562681429855 no 1146 0.353886272407789 387 6463460 SGTC_2956 9076196 2.52 µM 0.373810727525959 0.345946360882809 no 1147 0.354272568878937 402 16423868 SGTC_99 0109-0120 622.8 µM 0.373223098787698 0.346163517873965 no 1148 0.354491202936723 399 759414 SGTC_262 fenpropimorph 62.5 µM 0.370505302385436 0.347168531074722 no 1149 0.355503013249655 395 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1832 st054113 55 µM 0.370125962980014 0.347308892605577 no 1150 0.35564431899661 397 1251267 SGTC_3281 9140613 49.47 µM 0.367823077643941 0.348161445202326 no 1151 0.356502580029393 350 16013766 SGTC_2583 asiatic acid 100 µM 0.366632912923423 0.348602358098577 no 1152 0.35694642716439 414 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_6 0844-0013 19.835 µM 0.365966321137265 0.348849395623905 no 1153 0.35719510334978 398 1584900 SGTC_2108 5365811 200 µM 0.365259297715602 0.349111487067765 no 1154 0.357458929108164 348 780283 SGTC_1600 coumarin 106 71.1 µM 0.365208186349349 0.349130436688226 no 1155 0.357478003954619 417 100336 A hepatotoxic, DNA x-linker. SGTC_1084 voriconazole 435 nM 0.364562979022181 0.349369680665821 no 1156 0.35771882699949 406 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2142 5622915 118.518 µM 0.364494305180098 0.349395148569886 no 1157 0.357744462785649 374 5322196 SGTC_2791 5663188 71.43 µM 0.363620487638851 0.349719265642112 no 1158 0.358070712843594 433 54690634 SGTC_3297 9117502 71.43 µM 0.362952031354795 0.349967283939015 no 1159 0.358320358864414 359 7453720 SGTC_1793 st048256 72.231 µM 0.361856505120828 0.350373897018457 no 1160 0.358729632145696 409 672022 SGTC_862 0452-0056 10.2 µM 0.361466677645416 0.350518625921045 no 1161 0.358875305407139 381 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_456 gingerol 170 µM 0.361107080482147 0.350652150641311 no 1162 0.359009700211809 403 442793 A herb. SGTC_2234 tolnaftate 200 µM 0.36066635513823 0.350815824839979 no 1163 0.359174439429825 420 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2353 9059630 146.67 µM 0.360638330837755 0.350826233290023 no 1164 0.359184915550213 393 4779114 SGTC_3100 9120536 49.47 µM 0.360549747574789 0.350859134560817 no 1165 0.359218030683276 391 16421196 SGTC_1209 2323-2347 50.3 µM 0.357044007049518 0.352162119511238 no 1166 0.360529430587794 391 5412760 SGTC_1155 4088-0394 48.2 µM 0.356785087700313 0.352258421620839 no 1167 0.360626350412517 387 2326248 SGTC_1441 4106-0040 13 µM 0.356581026960481 0.352334326370105 no 1168 0.360702741631699 381 2904180 SGTC_3199 9111318 49.47 µM 0.356157387310577 0.352491926961601 no 1169 0.360861351125262 397 8548020 SGTC_1794 st048918 76.9 µM 0.355938672931698 0.352573302054192 no 1170 0.360943246542831 392 672303 SGTC_2151 5563267 85.4165 µM 0.355687092280005 0.352666913749564 no 1171 0.361037456293035 421 5310824 SGTC_521 r062-0005 13.8 µM 0.354749681395445 0.353015797400477 no 1172 0.361388564016376 385 2832033 SGTC_2051 5263410 176 µM 0.353654989505025 0.353423374015072 no 1173 0.361798729214153 376 227584 SGTC_651 3253-0966 34.4 µM 0.352120601038569 0.353994941762373 no 1174 0.362373909579423 388 781462 SGTC_1151 3909-8316 15.3 µM 0.351722699298975 0.354143216046403 no 1175 0.362523117701894 401 800431 SGTC_2379 9035213 200 µM 0.350983946932001 0.354418563699434 no 1176 0.3628001958642 415 646551 SGTC_1963 st076565 50.3 µM 0.349795856074212 0.354861548291473 no 1177 0.363245954598105 405 4914280 SGTC_2434 5670830 169.91 µM 0.347483387250414 0.355724324281172 no 1178 0.364114098482074 394 1549830 SGTC_422 cantharidin 155 µM 0.347211362002054 0.355825864884142 no 1179 0.364216267783131 372 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_245 methotrexate 289.6 µM 0.345597729736856 0.356428405811511 no 1180 0.36482252618375 396 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2826 7992541 19.48 µM 0.345582502997913 0.356434093286251 no 1181 0.364828248640562 439 2985066 SGTC_830 4076-0286 57.8 µM 0.34550252774582 0.356463966078467 no 1182 0.364858305138934 390 6866659 SGTC_2179 6298986 200 µM 0.34472160460945 0.356755707004663 no 1183 0.36515183723905 405 738374 SGTC_2293 7624732 200 µM 0.344650704204685 0.356782198462763 no 1184 0.365178491081883 381 894453 SGTC_2746 daunorubicin 9.88 µM 0.343235751647047 0.357311030239978 no 1185 0.365710555305196 407 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_229 benomyl 22.8748 µM 0.342349290425912 0.357642480656549 no 1186 0.366044022822904 393 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1856 st057054 55.7 µM 0.342139270952821 0.357721023289674 no 1187 0.366123042440589 411 1266018 SGTC_2053 5265679 138 µM 0.340654431121004 0.358276492217563 no 1188 0.36668187375738 391 764595 SGTC_358 0075-0058 9.45 µM 0.338768929495631 0.358982278462843 no 1189 0.367391904665483 429 1069125 SGTC_879 0831-1030 162 µM 0.338738654200411 0.358993615131408 no 1190 0.367403309261593 380 1549252 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.338107975551328 0.359229802732322 no 1191 0.367640910248816 388 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_27 0485-0001 32.618 µM 0.335975735584807 0.360028719350873 no 1192 0.368444582088517 403 2054479 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.335065652883852 0.360369899455433 no 1193 0.368787780879075 367 2724 A muscle relaxant with antifungal properties. SGTC_2496 diffractaic acid 79.83 µM 0.334087193128919 0.36073683743628 no 1194 0.369156881907595 387 94870 An apoptosis inducer which activates caspases. SGTC_2693 st077581 40.7 µM 0.333161875452945 0.361083964291327 no 1195 0.369506047358836 423 25238761 SGTC_1651 st011928 86.1 µM 0.333027573002202 0.361134356491179 no 1196 0.369556734881049 397 720198 SGTC_1056 3448-1962 115 µM 0.332755283217144 0.361236530907342 no 1197 0.369659507606173 404 715507 SGTC_1910 st062352 60.4 µM 0.332652350625611 0.361275158062047 no 1198 0.369698360784137 385 2245730 SGTC_1264 0783-0040 158 µM 0.332488323993043 0.361336714687032 no 1199 0.369760277411461 407 2855798 SGTC_3021 9087658 49.47 µM 0.332391914027675 0.361372897511645 no 1200 0.369796671735211 408 25237042 SGTC_821 1114-0266 29.2 µM 0.33162815222744 0.36165958241663 no 1201 0.370085029536573 411 3123235 SGTC_1245 0418-0076 17.2 µM 0.331445209191504 0.361728263277264 no 1202 0.370154110417507 409 6790114 SGTC_2907 7721985 69.9 µM 0.329855223784731 0.362325366326585 no 1203 0.370754678917846 376 3267881 SGTC_503 tyrphostin 8 294 µM 0.32965603986023 0.362400191498055 no 1204 0.370829936805583 434 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_98 0074-0023 107.663 µM 0.32860578791723 0.362794814638706 no 1205 0.371226836347906 406 3563821 SGTC_1650 st011916 45.8 µM 0.327662875678033 0.363149230004702 no 1206 0.371583287987254 426 242528 SGTC_2118 5526350 200 µM 0.327542752820573 0.363194389381693 no 1207 0.371628706268541 396 743594 SGTC_1717 st033143 58.0435 µM 0.325420751728485 0.363992454382672 no 1208 0.372431325938807 434 674616 SGTC_3129 9127257 49.47 µM 0.324284190609882 0.364420147486722 no 1209 0.372861443803215 415 837894 SGTC_897 1000-0139 31.4 µM 0.323818230978376 0.36459553904328 no 1210 0.37303782646822 428 6151020 SGTC_1372 2752-0194 270 µM 0.323307569247981 0.36478778944469 no 1211 0.373231161070266 400 823334 SGTC_1090 efavirenz 20.7 µM 0.322584316596121 0.365060132783135 no 1212 0.373505036404057 408 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_685 1278-0033 54.9 µM 0.32114567463155 0.365602060775463 no 1213 0.374049999304205 431 3590572 SGTC_1432 4049-0298 68.4 µM 0.320465309602889 0.365858443831196 no 1214 0.374307811869193 434 741646 SGTC_2121 5257820 149.641 µM 0.320110477630549 0.365992179519695 no 1215 0.374442291622511 408 791256 SGTC_935 2996-0153 430 µM 0.318740973732835 0.366508496253598 no 1216 0.374961470683027 410 23738523 SGTC_2231 micatex 6.853 µM 0.315874677306196 0.36758990013755 no 1217 0.37604881659481 413 20737 An antifungal of unknown mechanism. SGTC_2580 diallyl disulphide 81.36 µM 0.315720413942808 0.367648130898817 no 1218 0.376107365284744 381 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1804 st050076 49.1 µM 0.314083070042216 0.368266376688673 no 1219 0.376728973768798 395 3895976 SGTC_2433 5607874 27.82 µM 0.312511380345022 0.368860153139199 no 1220 0.377325957796149 411 2252428 SGTC_820 1582-0060 59.9 µM 0.311014995243667 0.369425770945541 no 1221 0.377894611012102 393 3848840 SGTC_108 0509-0257 621.132 µM 0.310810393296085 0.369503130326062 no 1222 0.377972384024443 397 536624 SGTC_2683 piperine 63.03 µM 0.309900751101838 0.369847127222588 no 1223 0.378318215805217 425 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1413 3910-0535 34.4 µM 0.309884020552991 0.369853455144859 no 1224 0.378324577413003 414 2876951 SGTC_613 3914-0030 117 µM 0.309769771030894 0.369896668183516 no 1225 0.378368020422839 422 1145395 SGTC_532 1548-0774 215 µM 0.309141671725666 0.3701342659418 no 1226 0.378606880591775 429 5932993 SGTC_2490 carminic acid 95.39 µM 0.308921642578813 0.370217510419124 no 1227 0.378690566550452 409 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2100 5377183 190 µM 0.308486491203895 0.370382160817302 no 1228 0.378856088914861 403 2844202 SGTC_382 3229-0966 23.2 µM 0.306947058277132 0.370964834180175 no 1229 0.379441834751075 421 5722370 SGTC_353 1988-1175 58.3 µM 0.306787144804321 0.371025378214306 no 1230 0.379502696849952 415 2788357 SGTC_1490 4089-0339 670 nM 0.30519290685216 0.371629138959029 no 1231 0.380109617192443 415 742542 SGTC_3203 9113543 49.47 µM 0.305009219996929 0.371698724126428 no 1232 0.380179565084811 394 17018012 SGTC_3061 glucosamine 200 µM 0.303876620005411 0.37212787381936 no 1233 0.380610945277434 429 91431 and experimental redox chemotherapeutic SGTC_2788 5282734 71.43 µM 0.303039851609635 0.37244503303122 no 1234 0.380929745713424 413 743706 SGTC_928 2764-0428 58.7 µM 0.300927220832536 0.373246165218743 no 1235 0.381734996313445 404 662578 SGTC_2994 9053520 71.4286 µM 0.299811675687147 0.373669413290555 no 1236 0.382160404437886 433 4647384 SGTC_355 1311-2252 105 µM 0.298915643786512 0.374009486423109 no 1237 0.382502205251713 405 5338538 SGTC_2076 5212012 200 µM 0.298758474813167 0.37406914725838 no 1238 0.382562168458973 411 604802 SGTC_625 k213-0058 121 µM 0.295280084453212 0.375390302768176 no 1239 0.383889964462481 408 3655420 SGTC_1975 st070967 30.8 µM 0.295092394596624 0.375461632500468 no 1240 0.383961649705374 453 261391 SGTC_1943 st076331 65.2 µM 0.292836249603523 0.376319391339869 no 1241 0.384823659507731 413 24208415 SGTC_3236 9132701 49.47 µM 0.29273454212675 0.376358073712202 no 1242 0.384862532535658 432 24282524 SGTC_860 0443-0016 25.1 µM 0.292123557946776 0.376590475256664 no 1243 0.3850960776213 401 5337942 SGTC_3087 9117406 49.47 µM 0.291431575177825 0.376853740454888 no 1244 0.385360634277453 361 42546093 SGTC_2168 5727979 200 µM 0.290386767435677 0.377251346575594 no 1245 0.385760182921795 396 695210 SGTC_2802 7925815 54.55 µM 0.289562111207253 0.377565265019303 no 1246 0.386075628274926 393 1262923 SGTC_1992 st073643 23.3 µM 0.288473884374587 0.377979639569702 no 1247 0.38649200923543 401 3161292 SGTC_870 0573-2213 57.6 µM 0.287869676526301 0.378209770236818 no 1248 0.386723249719076 399 3916321 SGTC_1748 st037455 53.6035 µM 0.286906930316717 0.378576550242665 no 1249 0.387091791928333 427 580690 SGTC_70 0141-0289 43.283 µM 0.286389776688152 0.378773616838585 no 1250 0.387289801981217 399 352408 SGTC_2606 farnesol 9.78 µM 0.284490565079823 0.379497600623822 no 1251 0.388017231722793 423 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_113 0099-0221 2.5 µM 0.284116816030238 0.379640124470839 no 1252 0.388160430218409 447 89219 SGTC_2978 9011784 42.97 µM 0.281709049497431 0.380558683009641 no 1253 0.389083307461317 416 2994934 SGTC_1376 2910-0861 41.3 µM 0.281094206301544 0.380793352772321 no 1254 0.389319072399369 407 1112859 SGTC_1985 st071382 65.5 µM 0.280644800258712 0.380964907199132 no 1255 0.38949142535231 416 6123237 SGTC_3027 9089541 49.47 µM 0.279804774948071 0.381285637757584 no 1256 0.389813644048915 412 9943819 SGTC_3268 9137683 49.47 µM 0.277679377488703 0.382097500768477 no 1257 0.390629246320806 467 1953228 SGTC_2468 5987765 72.9 µM 0.276577857876148 0.382518465447957 no 1258 0.391052134273264 402 26772094 SGTC_130 0136-0219 337.655 µM 0.276195661684514 0.382664560775956 no 1259 0.391198894582727 452 234244 SGTC_2236 dapsone 200 µM 0.275917525257858 0.382770889530917 no 1260 0.391305706507887 425 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2992 9074591 71.4286 µM 0.275833605231188 0.382802973047584 no 1261 0.39133793568245 408 17741321 SGTC_1133 3473-0247 50 µM 0.274778641204771 0.383206365520812 no 1262 0.391743154268577 400 711311 SGTC_2373 9071805 200 µM 0.274762153742696 0.383212670929996 no 1263 0.39174948814412 428 10149009 SGTC_128 0906-2981 13.371 µM 0.274102976486505 0.383464789777879 no 1264 0.39200274325131 427 6740226 SGTC_1876 myriocin 605 nM 0.273185114118858 0.383815931410834 no 1265 0.392355461069594 451 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2033 5192550 145 µM 0.271927985966054 0.384297018909415 no 1266 0.392838696043639 418 182073 SGTC_1879 gemcitabine 100 µM 0.271688773897886 0.384388582642399 no 1267 0.39293066692683 427 60750 A nucleoside analog which inhibits DNA replication. SGTC_1642 st009582 77.7 µM 0.271349139996338 0.384518596143827 no 1268 0.393061257687317 439 6739311 SGTC_1420 4'-methoxyflavone 42 µM 0.271236692246032 0.384561644550163 no 1269 0.393104497005099 438 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2641 levomentholum 100 µM 0.269631756592307 0.38517621746528 no 1270 0.393721783330002 442 16666 SGTC_828 2074-0507 139 µM 0.268623529046455 0.385562442494652 no 1271 0.394109702016405 416 X828 SGTC_3128 9127691 49.47 µM 0.267988542002043 0.385805747340463 no 1272 0.39435406920931 443 41316314 SGTC_1498 4478-3555 97.6 µM 0.264333903595595 0.387206947799753 no 1273 0.395761318876051 445 3437919 SGTC_2942 9052777 62.25 µM 0.263749784046171 0.387431037977113 no 1274 0.395986365607445 440 6469503 SGTC_1931 st074438 57.1 µM 0.261482005160807 0.388301397936791 no 1275 0.396860412371589 457 2787313 SGTC_3352 9151559 45.5865 µM 0.261059150988348 0.388463749047422 no 1276 0.397023446193557 408 17159339 SGTC_2160 5660466 132.927 µM 0.260851290783599 0.388543562276218 no 1277 0.397103594473044 442 2859134 SGTC_1803 st050068 52.4 µM 0.260708710618153 0.388598312289667 no 1278 0.397158574103851 435 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_791 1348-1292 225 µM 0.256704206152618 0.390136920552683 no 1279 0.3987035621473 427 5437054 SGTC_3035 9091303 49.47 µM 0.256283890491746 0.390298514287443 no 1280 0.398865817746387 448 25237002 SGTC_79 0052-0007 94.094 µM 0.255222126772283 0.390706802244949 no 1281 0.399275771071835 450 2801472 SGTC_2320 7373003 200 µM 0.254176067302315 0.391109169201613 no 1282 0.399679769548292 404 5415828 SGTC_2435 5706476 10.6 µM 0.253538309403289 0.391354540120736 no 1283 0.399926130675835 430 5725375 SGTC_1086 cerivastatin 2.18 µM 0.25279682672319 0.391639872460383 no 1284 0.400212609992376 425 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1299 1079-1439 3.74 µM 0.252122097574378 0.391899567831231 no 1285 0.400473345081675 425 323161 SGTC_1811 st050069 61.5 µM 0.251617793272596 0.392093700131275 no 1286 0.400668251995856 458 3877702 SGTC_2270 7924575 90.91 µM 0.249622796556232 0.392861938434354 no 1287 0.401439533736097 430 1262135 SGTC_3354 9151612 71.43 µM 0.249070538367455 0.393074677308664 no 1288 0.401653109202923 446 27261949 SGTC_46 0329-0187a 2.197 µM 0.2470006057113 0.393872332876039 no 1289 0.402453877653006 441 46494817 SGTC_1877 wortmannin 25 µM 0.246192744182345 0.394183766095445 no 1290 0.402766516021383 451 312145 A covalent inhibitor of PI 3-kinase. SGTC_2022 5136654 200 µM 0.245435080485849 0.394475909385528 no 1291 0.403059784594098 451 1713771 SGTC_1653 st012112 65 µM 0.244738308350991 0.394744626244264 no 1292 0.403329532040747 440 720429 SGTC_853 0419-0306 21 µM 0.243056277039517 0.395393523910455 no 1293 0.403980900757603 427 762713 SGTC_2292 7671323 168.05 µM 0.242135974467617 0.39574868314041 no 1294 0.404337401916973 450 937504 SGTC_2646 retinol 96.75 µM 0.241512888087003 0.395989191140829 no 1295 0.404578814416256 443 445354 A vitamin A analog and teratogen. SGTC_1457 k015-0032 57.3 µM 0.241192689061299 0.396112801656864 no 1296 0.404702888475127 411 4302660 SGTC_477 mead ethanolamide 10 µM 0.241005278241665 0.39618515509424 no 1297 0.404775512821064 423 16061185 SGTC_2742 clothiapine 36.27 µM 0.24072043265118 0.396295131887155 no 1298 0.404885900801132 454 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2493 resveratrol 26.09 µM 0.239511993936926 0.396761792885272 no 1299 0.405354298630761 427 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1373 2887-0003 58.5 µM 0.23680793434584 0.397806550393917 no 1300 0.406402897949231 420 776948 SGTC_447 ml7 120 µM 0.234607030508462 0.398657447201209 no 1301 0.40725687614168 441 4216 Selective myosin light chain kinase inhibitor. SGTC_2849 9019321 12.99 µM 0.233934694030269 0.3989174771386 no 1302 0.407517839225847 429 16489627 SGTC_1545 lovastatin 49.4 µM 0.232624297791836 0.399424409147268 no 1303 0.408026578971242 446 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3198 9112019 49.47 µM 0.23238220987845 0.399518080409638 no 1304 0.40812058261281 478 45595555 SGTC_3222 9128301 49.47 µM 0.232056154720042 0.399644250323402 no 1305 0.408247199406554 471 4911358 SGTC_757 1066-0008 322 µM 0.230894512482168 0.400093843106769 no 1306 0.408698376984086 422 6842497 SGTC_3191 9110352 49.47 µM 0.230010960533495 0.400435894751012 no 1307 0.409041626382789 436 17122424 SGTC_2827 7993847 71.43 µM 0.227826769060501 0.401281793428329 no 1308 0.409890457595105 455 2985692 SGTC_2919 7978188 46.38 µM 0.226828275834283 0.401668646592754 no 1309 0.410278637884483 426 2980291 SGTC_149 3970-0822 46.1 µM 0.225705979046223 0.402103580865047 no 1310 0.41071505373685 428 3114250 YBL034C STU1 SGTC_1382 3002-2117 298 µM 0.225536606200253 0.402169230066438 no 1311 0.410780925604501 465 1497314 SGTC_832 4083-0019 164 µM 0.225507086924694 0.402180672070007 no 1312 0.410792406390713 426 1990758 SGTC_1622 st003707 19.4 µM 0.224694197989217 0.402495789877237 no 1313 0.411108589270765 451 10140899 SGTC_1119 parthenolide 318.541 nM 0.223296192435681 0.403037877248357 no 1314 0.411652495228978 448 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1903 st060211 78.3 µM 0.222685990499235 0.40327454622959 no 1315 0.411889952782231 430 688960 SGTC_1695 st026914 34.495 µM 0.221579386643329 0.403703836791076 no 1316 0.412320665348294 433 3289191 SGTC_2346 9031566 143.75 µM 0.221536664451238 0.403720412561743 no 1317 0.41233729580896 450 4771086 SGTC_1065 prochlorperazine maleate 2.48 µM 0.221164259142216 0.403864909307603 no 1318 0.412482268625016 477 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_50 0929-0078 56.389 µM 0.220738662749656 0.404030060755909 no 1319 0.412647962696873 456 1377751 SGTC_2106 5357045 167.29 µM 0.220056569783146 0.40429478062595 no 1320 0.412913549002679 436 668842 SGTC_2507 purpurin 79.67 µM 0.219901362766183 0.404355022500886 no 1321 0.412973987478084 459 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1146 3579-1023 7 µM 0.219662567343653 0.404447712712689 no 1322 0.413066979771308 440 X1146 SGTC_2617 dihydrotanshinone i 20.83 µM 0.218581149923563 0.404867539960849 no 1323 0.413488168959803 434 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2318 6029776 164 µM 0.218411815897727 0.404933288648798 no 1324 0.413554130005932 454 818325 SGTC_1229 0139-0193 12.2 µM 0.218204508415237 0.405013785250852 no 1325 0.413634886255411 441 3090752 SGTC_771 0250-0039 27.3 µM 0.218081228721951 0.405061656130368 no 1326 0.413682911366111 477 3005115 SGTC_2652 actinonin 100 µM 0.217975745147359 0.405102617706391 no 1327 0.413724004806417 456 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2460 5552655 174.22 µM 0.216138826101726 0.405816099806813 no 1328 0.414439768027644 420 5401989 SGTC_2250 alverine citrate 130 µM 0.21425567105722 0.4065478654368 no 1329 0.415173842336957 454 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1843 st055809 45.5 µM 0.213838287270621 0.40671009876538 no 1330 0.41533658326784 431 16413835 SGTC_3092 9117248 49.47 µM 0.212194147535754 0.407349316623258 no 1331 0.415977786187218 470 17141857 SGTC_2224 6650123 117.647 µM 0.211004398690257 0.40781202786611 no 1332 0.416441919486495 465 2908370 SGTC_2187 6125751 200 µM 0.210966892633792 0.407826616630861 no 1333 0.416456552884064 446 874498 SGTC_1870 st057514 26.5 µM 0.210681672159715 0.40793756327706 no 1334 0.416567838554077 446 5393161 SGTC_47 0149-0135 24.25 µM 0.210120144157948 0.408156011128302 no 1335 0.416786951827353 465 5239155 SGTC_2654 protoveratrine a 100 µM 0.208080285003297 0.408949804975278 no 1336 0.417583140269146 477 5702278 A heart drug and vasodilator. SGTC_1775 st081588 35.1725 µM 0.206235410455353 0.409668044053138 no 1337 0.418303514399539 438 1426443 YGL099W LSG1 SGTC_460 trequinsin 123 µM 0.206191950617197 0.40968496732648 no 1338 0.41832048761731 460 5537 A vasodilator. SGTC_724 3910-0327 137 µM 0.206018897254125 0.40975235602399 no 1339 0.418388075028906 470 2885483 SGTC_1829 berberine 14.4 µM 0.205644007511888 0.409898350952265 no 1340 0.418534499557104 456 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2616 abietic acid 100 µM 0.204783614202866 0.410233464830449 no 1341 0.418870594841388 479 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1421 4029-0249 71.4 µM 0.204651217898971 0.410285037583905 no 1342 0.418922318049621 454 2894095 SGTC_1168 k815-0004 80.5 µM 0.203738942696697 0.410640441179526 no 1343 0.419278754270253 449 642433 SGTC_2063 5246145 200 µM 0.20257165858801 0.411095297969449 no 1344 0.419734921935604 455 711240 SGTC_2447 5741742 33.78 µM 0.201536221659789 0.411498877816638 no 1345 0.420139654816464 444 1776504 SGTC_2268 7933382 153.85 µM 0.200523877130199 0.411893547548271 no 1346 0.420535442977646 397 935025 YOR257W CDC31 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.200174460466389 0.41202979083966 no 1347 0.420672070260656 454 17037758 SGTC_2804 7954240 19.48 µM 0.199985195472534 0.412103592795305 no 1348 0.420746079771771 440 828705 SGTC_191 3914-0123 66.505 µM 0.199489809242584 0.412296778318109 no 1349 0.420939807099439 470 3144412 SGTC_2918 7977171 22.06 µM 0.199301319736166 0.412370289061543 no 1350 0.421013523441062 449 2236483 SGTC_1483 3453-0561 55.9 µM 0.198433774083072 0.412708670709848 no 1351 0.421352847447645 463 4546991 SGTC_1977 st070720 65.3 µM 0.197912452773436 0.412912040586562 no 1352 0.42155678049348 431 682188 SGTC_647 0140-0236 81 µM 0.196731182653336 0.41337294598751 no 1353 0.42201895335147 455 990837 SGTC_143 4032-1194 15.74 µM 0.196669180723197 0.413397141069007 no 1354 0.422043214627536 440 1806963 SGTC_583 1488-1091 88.9 µM 0.194874527450626 0.414097612759869 no 1355 0.422745588010834 471 4303273 SGTC_2472 5377652 49.4 µM 0.194619063428667 0.414197345280747 no 1356 0.422845588981489 459 1610903 SGTC_2830 7992007 71.43 µM 0.192864176970802 0.414882597829754 no 1357 0.423532670451333 473 1952075 SGTC_187 1488-2104 32.728 µM 0.192566455279176 0.414998878717766 no 1358 0.423649258992705 468 2852859 SGTC_3052 9092717 49.47 µM 0.192546520655615 0.415006664831526 no 1359 0.423657065678842 450 25237534 SGTC_283 0987-0079 11.7 µM 0.191095324290215 0.415573566122811 no 1360 0.424225455406647 474 411556 SGTC_2171 5739187 198.077 µM 0.190722590777169 0.415719200686316 no 1361 0.424371469342508 452 2262761 SGTC_2143 5623677 140.463 µM 0.188502666993353 0.416586809182567 no 1362 0.425241312517689 468 5375313 SGTC_254 nsc-64875 3.808 µM 0.187421620226759 0.417009460033671 no 1363 0.425665036227554 470 56993 SGTC_1635 st007035 42.4 µM 0.187267024102842 0.417069909473377 no 1364 0.425725638269166 437 3716403 SGTC_1681 tripelennamine 100 µM 0.186656050266868 0.41730882872277 no 1365 0.4259651585948 429 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3015 9080845 49.47 µM 0.186539971447765 0.417354224406324 no 1366 0.426010668112888 468 5296973 SGTC_2470 5664817 21.68 µM 0.186488017883095 0.417374542574863 no 1367 0.426031037192874 469 2859561 SGTC_1266 0828-0227 32.9 µM 0.186332743625124 0.417435269050026 no 1368 0.426091915688966 436 3913820 SGTC_1267 0828-0272 9.49 µM 0.185771445908255 0.417654804350411 no 1369 0.426311998792311 466 745334 SGTC_3069 9117009 49.47 µM 0.185416788703021 0.417793531452968 no 1370 0.426451070624426 470 41904981 SGTC_1437 4092-1038 11.6 µM 0.18506551504329 0.417930945138432 no 1371 0.42658882468104 469 3977136 SGTC_2570 licareol 100 µM 0.184648343627071 0.418094150183539 no 1372 0.426752432566891 450 443158 SGTC_544 k015-0020 52.4 µM 0.184322754435155 0.418221536398352 no 1373 0.426880132142903 460 3008304 SGTC_703 3875-0075 71.8 µM 0.182745379418308 0.418838802898127 no 1374 0.427498903823371 483 2850814 SGTC_1284 0929-0043 16 µM 0.181627134446913 0.419276521429897 no 1375 0.427937676406846 463 1239883 SGTC_2553 4-methylesculetin 85.09 µM 0.181458187654394 0.419342661564445 no 1376 0.428003974850654 429 5319502 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.181400630382173 0.419365194893557 no 1377 0.428026562056708 466 688751 SGTC_3029 9088683 49.47 µM 0.180692520782535 0.419642437200038 no 1378 0.428304464852961 436 25236615 SGTC_137 0438-0332 85.389 µM 0.18066800478169 0.419652036531976 no 1379 0.428314086974632 481 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_533 1222-0222 6.71 µM 0.180475643511701 0.419727357966506 no 1380 0.42838958704528 472 3982874 SGTC_1625 st003711 30.1 µM 0.180327945106428 0.41978519309999 no 1381 0.428447559121761 461 24207034 YER133W GLC7 SGTC_1570 verbenone 133 µM 0.178620149260163 0.420454050291408 no 1382 0.429117986053925 476 29025 A natural terpanoid with antifungal properties. SGTC_1955 wogonin 32.4 µM 0.178587833765444 0.420466708855859 no 1383 0.4291306740785 412 5281703 A flavanone. SGTC_1688 st021091 57.6 µM 0.178284707492282 0.420585452908803 no 1384 0.429249694034145 479 3656366 SGTC_719 2810-4230 27.3 µM 0.176872315639252 0.421138826139157 no 1385 0.429804342333642 483 721079 SGTC_1214 0358-0031 63.7 µM 0.176438081865079 0.421308989717688 no 1386 0.429974894458699 471 4301366 SGTC_2592 piperlongumine 83.33 µM 0.175457829103775 0.421693176241956 no 1387 0.430359952101478 454 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_172 1112-0046 2.638 µM 0.174999482488652 0.421872839788177 no 1388 0.430540020112199 454 2802135 YIL048W NEO1 SGTC_843 0310-0051 143 µM 0.17305237878898 0.422636249905135 no 1389 0.431305128162868 484 2065037 SGTC_271 rotenone 740 µM 0.171781197712437 0.423134804865376 no 1390 0.431804773917132 469 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_81 0411-0046 9.971 µM 0.171085448694566 0.423407728577485 no 1391 0.432078288719898 463 12925265 SGTC_2304 7443016 91.4 µM 0.171007748450891 0.423438210586637 no 1392 0.432108836480817 489 939854 SGTC_3254 9136651 49.47 µM 0.170565296307587 0.423611794449968 no 1393 0.432282793760262 489 16454030 SGTC_1467 k284-1082 293 µM 0.170320195207974 0.423707959471779 no 1394 0.432379164909637 458 3334705 SGTC_2587 piperic acid 92.2 µM 0.1699958347463 0.423835228761277 no 1395 0.432506706182497 482 5370536 SGTC_1393 3470-5649 58.2 µM 0.169233343640654 0.424134438604947 no 1396 0.432806551799594 484 4108395 SGTC_2206 7254556 146.969 µM 0.168111603334498 0.424574701211859 no 1397 0.43324774056234 476 4398905 SGTC_2107 5363541 170.161 µM 0.167774096576492 0.424707184901399 no 1398 0.433380500775916 494 244052 SGTC_2785 7756463 72.73 µM 0.166415351315627 0.425240627782683 no 1399 0.433915046899234 494 2201551 SGTC_1722 st034304 3.6505 µM 0.166384603708323 0.425252700869484 no 1400 0.433927144766409 466 4036148 YLR033W RSC58 SGTC_1888 azatryptophan 97.5 µM 0.166212463671032 0.425320293166722 no 1401 0.433994875644674 435 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2480 5767542 37.17 µM 0.166154199741484 0.425343171507601 no 1402 0.434017800832576 474 2867358 SGTC_3113 9123498 49.47 µM 0.165629996827144 0.425549020156105 no 1403 0.434224069640707 475 8897275 SGTC_1693 xanthone 101.9 µM 0.165081178106453 0.425764556903533 no 1404 0.434440043722182 484 7020 An insecticide. SGTC_1669 st015249 58.4 µM 0.164912615748795 0.425830760599482 no 1405 0.434506381214616 481 722793 SGTC_324 1315-0088 19.6 µM 0.162159705867175 0.426912274090676 no 1406 0.435590044911915 494 6787421 SGTC_835 0312-0010 67.2 µM 0.160197160282852 0.427683619632885 no 1407 0.436362883136326 462 1626196 SGTC_71 0417-1750 47.813 µM 0.158944482394141 0.428176108361125 no 1408 0.436856307128612 499 6811472 SGTC_1316 1272-0050 65.9 µM 0.157012911741622 0.428935721951579 no 1409 0.437617336110725 472 7340392 SGTC_3137 9097352 49.47 µM 0.156435944895378 0.429162672358043 no 1410 0.437844703004774 486 44120435 SGTC_3145 9085516 49.47 µM 0.156211099007849 0.429251122027378 no 1411 0.437933314196421 442 25236195 SGTC_115 0527-0192 112.043 µM 0.155049164725347 0.42970825918556 no 1412 0.438391279041288 488 4233931 SGTC_1242 0402-0103 60.1 µM 0.154421810859136 0.429955116813679 no 1413 0.438638578670839 457 432868 SGTC_2026 5148700 152 µM 0.154317835852832 0.429996032612627 no 1414 0.438679567394304 452 79838 SGTC_3009 9080819 71.4286 µM 0.154190071503419 0.43004631092137 no 1415 0.438729935183725 456 17027216 SGTC_2225 6654152 15.4 µM 0.153420178559057 0.430349306081589 no 1416 0.439033466535627 484 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1179 1021-1431 9.29 µM 0.153317151869324 0.430389855858175 no 1417 0.439074087673602 483 2840958 SGTC_1325 1431-0015 227 µM 0.152796327584063 0.430594855796496 no 1418 0.439279446945992 457 1103340 SGTC_2377 9073351 62.6 µM 0.152748278052349 0.430613769358322 no 1419 0.43929839353978 473 7337946 YHR072W ERG7 SGTC_2921 7974240 10.71 µM 0.147716433211465 0.432595309033006 no 1420 0.441283281044265 472 2979074 YDR527W RBA50 SGTC_1821 st053465 65.6 µM 0.146935942750502 0.432902819276074 no 1421 0.441591290800116 458 675086 SGTC_2626 ethyl orsellinate 100 µM 0.146045651668655 0.43325364014629 no 1422 0.441942674969692 484 75653 A natural product. SGTC_17 0960-0276 49.807 µM 0.145574588198341 0.433439284887577 no 1423 0.442128614962742 476 6821114 SGTC_962 1254-0300 21.5 µM 0.145078855499406 0.433634667559944 no 1424 0.44232430625866 479 7340576 SGTC_1667 st014849 34.6 µM 0.144661861291292 0.433799029664408 no 1425 0.44248892630707 490 5348460 SGTC_261 5-fluorouridine 15.376 µM 0.144656209922382 0.433801257282158 no 1426 0.44249115741022 453 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_850 0388-0143 75.9 µM 0.143612106911669 0.434212850635285 no 1427 0.442903389917136 462 67273 SGTC_2297 7971671 152.32 µM 0.142494713772189 0.434653414520244 no 1428 0.443344627282464 475 909016 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.141991568101313 0.434851820480083 no 1429 0.443543332942242 430 6708561 SGTC_2123 5259487 200 µM 0.14136355713008 0.435099487718041 no 1430 0.443791371155806 487 2173474 SGTC_909 3448-9333 149 µM 0.139579497360938 0.435803201856366 no 1431 0.444496120378662 476 3344074 SGTC_690 glyoxal 20.3 µM 0.13919556473043 0.43595466896951 no 1432 0.444647806609224 485 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2339 9000433 200 µM 0.138476393672551 0.436238417873024 no 1433 0.444931962492213 468 2988954 SGTC_1424 4048-1941 275 µM 0.13657702610416 0.43698797066381 no 1434 0.445682568411211 498 X1424 SGTC_2348 9022543 33.42 µM 0.13604440880163 0.437198199669688 no 1435 0.445893087074124 504 3162678 YDL140C RPO21 SGTC_2806 7952793 58.44 µM 0.135938922870645 0.437239838054085 no 1436 0.445934782531548 465 2972490 SGTC_2948 9070189 9.45 µM 0.135035975812409 0.437596286082036 no 1437 0.446291715118517 488 6473636 YDL196W YDL196W SGTC_3171 9103192 49.47 µM 0.135028368182499 0.437599289491044 no 1438 0.446294722579821 494 13018434 SGTC_2131 toluylene red 5.2905 µM 0.134284094261999 0.437893138042391 no 1439 0.446588965131706 461 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2439 5492030 7.2 µM 0.133992093280012 0.438008433006474 no 1440 0.446704413351323 485 5722370 SGTC_1064 honokiol 6.76 µM 0.133306348231934 0.43827921629996 no 1441 0.446975553624201 490 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1342 1486-1464 234 µM 0.131982049876736 0.438802229751863 no 1442 0.447499244829711 487 3253938 SGTC_1232 0279-0259 161 µM 0.131755457844227 0.43889172989698 no 1443 0.447588859404115 484 1560000 SGTC_265 mycophenolic acid 32.932 µM 0.130703662260482 0.439307212783433 no 1444 0.448004867568155 484 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1088 bifonazole 369 nM 0.129343491120397 0.439844610032985 no 1445 0.448542929750945 495 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1405 3909-7894 12 µM 0.129330261816294 0.439849837415037 no 1446 0.448548163520788 490 7104060 SGTC_1971 st069429 63.5 µM 0.129056173128103 0.439958142241297 no 1447 0.448656600346678 510 1246522 YGL099W LSG1 SGTC_116 0155-0182 31.788 µM 0.129047470624991 0.439961581067164 no 1448 0.448660043352856 466 771486 SGTC_3211 9128781 49.47 µM 0.128575873298612 0.440147941238444 no 1449 0.448846629068285 468 17194361 SGTC_2485 5633444 17.78 µM 0.128558200169534 0.440154925351512 no 1450 0.448853621595794 482 5724239 SGTC_18 0111-0177 500 nM 0.128416869805019 0.440210777321845 no 1451 0.448909540757296 477 721752 SGTC_819 1013-0258 27.7 µM 0.127775697448275 0.440464175443248 no 1452 0.449163241508872 472 5753198 SGTC_411 enrofloxacin 100 µM 0.126545983057384 0.440950239765988 no 1453 0.44964987618215 493 71188 A bacterial gyrase inhibitor. SGTC_2920 7982904 15.77 µM 0.126174099327505 0.441097250325428 no 1454 0.449797056617061 488 6456808 SGTC_1511 0906-3109 28.5 µM 0.126055817220309 0.441144010509957 no 1455 0.449843870578745 463 2882180 SGTC_2395 5646831 180.19 µM 0.125664496975291 0.441298716057067 no 1456 0.449998753167297 487 6808628 SGTC_2001 4023502 57.655 µM 0.125595826622889 0.44132586529443 no 1457 0.450025933334279 475 108941 YCR052W RSC6 SGTC_2981 9013952 38.96 µM 0.123970372472985 0.441968578605305 no 1458 0.450669366705235 463 2996344 SGTC_663 1486-0733 13.9 µM 0.123626153796744 0.442104704183385 no 1459 0.450805641800105 470 722445 YPR165W RHO1 SGTC_570 0987-0065 62.6 µM 0.122494390298485 0.442552322314936 no 1460 0.451253744215504 505 3104428 SGTC_444 curcumin 90.4 µM 0.121072898958776 0.443114633105899 no 1461 0.451816647368903 479 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1889 st059080 5.18 µM 0.120223918075082 0.443450526047663 no 1462 0.452152885653095 468 176925 Isolated from Daphnopsis sellowiana. SGTC_12 0849-0099 9.267 µM 0.119348023056553 0.443797109952501 no 1463 0.452499819229031 504 6071388 SGTC_3182 9108849 49.47 µM 0.118613671755553 0.444087719404695 no 1464 0.452790716664454 473 17133045 SGTC_2540 epiandrosterone 100 µM 0.118554310265812 0.444111212215317 no 1465 0.452814232547813 498 441302 A steroid. SGTC_287 k060-0039 29.6 µM 0.11685810877925 0.444782580930086 no 1466 0.453486247494944 473 5861974 SGTC_1673 st016611 27.3 µM 0.116784359304562 0.44481177510906 no 1467 0.453515469199461 497 5226799 SGTC_1456 k015-0012 13 µM 0.116294900736086 0.44500553784502 no 1468 0.453709413407865 491 2989616 SGTC_3251 9135047 49.47 µM 0.115221058335933 0.445430687505898 no 1469 0.454134953849202 499 17682963 SGTC_2291 7917025 104.35 µM 0.11501855855579 0.445510867131917 no 1470 0.454215206033539 495 2964612 SGTC_331 k048-0133 24.5 µM 0.114712791579184 0.445631939544198 no 1471 0.454336387324753 493 6813582 SGTC_2713 st079149 53.4 µM 0.114060964427258 0.445890055896548 no 1472 0.454594733046004 493 3103253 SGTC_1227 3909-8010 46.6 µM 0.113856116386977 0.445971178199212 no 1473 0.454675926662374 494 15982272 SGTC_2963 9082507 9 µM 0.112788869786525 0.446393857278072 no 1474 0.455098971328235 486 16459611 SGTC_2080 5212524 12.4 µM 0.112214384481574 0.446621405314707 no 1475 0.455326712019631 495 260183 SGTC_1881 5652484 16 µM 0.112195903994923 0.446628725547764 no 1476 0.455334038402095 500 2255129 SGTC_638 3970-0837 4.09 µM 0.111274397828554 0.446993762751607 no 1477 0.455699378439281 482 4118451 YLR208W SEC13 SGTC_446 go6976 132 µM 0.110858159867828 0.447158662274968 no 1478 0.455864412308068 499 3501 A protein kinase C inhibitor. SGTC_918 glabranin 770.725 nM 0.110513279347621 0.447295299294681 no 1479 0.456001159490382 488 124049 Also referred to as licorice root. SGTC_1933 st074711 15.9 µM 0.109544775475071 0.447679040890189 no 1480 0.456385204867849 516 17250958 SGTC_228 caffeine 993.056 µM 0.109395087756157 0.447738354690131 no 1481 0.456444564884714 479 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_659 k018-0002 107 µM 0.109257188799652 0.447792998223948 no 1482 0.456499250821624 490 6797879 YHR007C ERG11 SGTC_993 3909-8757 62.7 µM 0.107379908614572 0.448536983219329 no 1483 0.457243796471163 492 4288324 YLR208W SEC13 SGTC_11 0438-0307 1.3 µM 0.107352676257409 0.448547777014379 no 1484 0.45725459817165 495 4011476 SGTC_933 2914-0560 114 µM 0.107136682387698 0.448633389518204 no 1485 0.457340273147045 471 463887 SGTC_1476 4112-3294 3.34 µM 0.10695211386644 0.448706547995656 no 1486 0.457413484682539 508 704369 SGTC_379 3970-0972 5.9 µM 0.106585204439624 0.448851987155473 no 1487 0.457559028430129 484 2898042 YBL034C STU1 SGTC_2877 9040724 71.43 µM 0.105866603413752 0.449136853178899 no 1488 0.457844095868023 474 6463895 SGTC_393 acivicin 6.25 µM 0.105551492436727 0.449261776963509 no 1489 0.457969106544578 496 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.105431143605183 0.449309489836297 no 1490 0.458016852373585 494 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2285 7945142 200 µM 0.10482997678239 0.449547836274554 no 1491 0.458255361531115 503 2970608 SGTC_421 streptovitacin 30 mM 0.104270679549007 0.449769598897426 no 1492 0.458477272691556 467 91467 include heat shock SGTC_1662 st014054 52 µM 0.103987605365839 0.449881844437419 no 1493 0.458589592363435 500 2838777 SGTC_1426 4048-4480 71.7 µM 0.103610323129672 0.450031451907721 no 1494 0.458739297543357 492 14224343 SGTC_2624 nerol 100 µM 0.103569262909413 0.450047734353341 no 1495 0.458755590547468 495 637566 A natural product oil. SGTC_3310 9130229 44.1445 µM 0.102294077088153 0.450553451487732 no 1496 0.459261628223234 502 7761258 SGTC_2591 skatole 100 µM 0.101182100528011 0.450994508151765 no 1497 0.459702952749497 500 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1518 st038567 90.8 µM 0.100730651938669 0.451173588948233 no 1498 0.459882139195844 511 77966 SGTC_3002 9075603 71.4286 µM 0.100698814407139 0.451186218647811 no 1499 0.459894776278616 512 20105405 SGTC_1831 st055328 12 µM 0.0997194835228424 0.451574735621878 no 1500 0.460283516013542 501 1103068 SGTC_2944 9067346 25.62 µM 0.0981151687233265 0.452211294260124 no 1501 0.460920421371639 489 6473075 SGTC_2786 7743617 45.45 µM 0.0980991451538295 0.452217652700584 no 1502 0.460926783161049 496 583674 SGTC_295 k015-0027 31 µM 0.0976156396549222 0.452409522132152 no 1503 0.461118752585267 494 3887424 SGTC_53 0973-0023 39.979 µM 0.0967620996350285 0.452748259420209 no 1504 0.461457661379908 496 674768 SGTC_1709 st033179 39.1045 µM 0.0965906219734675 0.452816316481904 no 1505 0.461525752125603 510 573381 SGTC_2232 chlorophetanol 41.5365 µM 0.0964384906426802 0.452876696418601 no 1506 0.4615861617298 505 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1726 st035556 14.5795 µM 0.0951689693075157 0.453380603540309 no 1507 0.462090308496718 448 5919439 SGTC_1430 4049-0248 69.1 µM 0.094425232977129 0.453675847393943 no 1508 0.462385686167107 504 22774488 SGTC_1575 cyproterone acetate 48 µM 0.0941696690740726 0.453777305492118 no 1509 0.46248718912579 506 9880 An androgen receptor antagonist and liver toxin. SGTC_1591 genipin 88.4 µM 0.0939302280154958 0.453872365607004 no 1510 0.462582290750403 510 442424 A DNA cross-linking agent. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0933670941079942 0.454095944912991 no 1511 0.462805965696413 497 66535 A nucleotide analog. SGTC_2030 5175110 200 µM 0.0928642564148575 0.454295597296375 no 1512 0.463005701124699 514 2831986 SGTC_2724 maprotiline 69.64 µM 0.0924608105747046 0.454455794363132 no 1513 0.463165963215259 515 4011 A tricyclic antidepressant. SGTC_3085 9117376 49.47 µM 0.0916150402546993 0.454791650131952 no 1514 0.463501950656087 512 16480349 SGTC_2922 7999257 32.47 µM 0.0912385313014738 0.454941172414833 no 1515 0.46365152953315 514 2988377 SGTC_3083 9117465 49.47 µM 0.0908525269212054 0.455094472225994 no 1516 0.463804886072614 507 16420915 SGTC_534 k292-0788 63.4 µM 0.0895372061205628 0.455616895734178 no 1517 0.464327493051961 507 4146317 SGTC_630 4356-0227 183 µM 0.0891413673247966 0.455774131375067 no 1518 0.464484780931387 517 779312 SGTC_1805 st050013 60.3 µM 0.088894636089649 0.455872141807941 no 1519 0.464582823228559 515 4037144 SGTC_508 roscovitine 141 µM 0.0872198801734759 0.456537485172165 no 1520 0.465248368740064 513 160355 A CDKinase inhibitor. SGTC_603 3794-0023 45.9 µM 0.0854179157065784 0.457253501731211 no 1521 0.465964575270509 500 3802260 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0851231387442446 0.457370645605142 no 1522 0.466081747505034 511 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3010 9080089 71.4286 µM 0.0846432688541431 0.45756135301844 no 1523 0.466272499453142 489 17027233 SGTC_1231 0242-0792 125 µM 0.0843887969677648 0.457662487889045 no 1524 0.466373657119023 500 3707635 SGTC_402 epigallocatechin gallate 10 µM 0.0841677491230227 0.457750341253755 no 1525 0.466461529822977 503 65064 An antioxidant. SGTC_595 3909-8003 73.7 µM 0.0823007226643326 0.458492455104371 no 1526 0.467203789884328 512 699517 SGTC_2965 9082772 38.63 µM 0.0820960377893322 0.458573822992567 no 1527 0.467285171938137 490 16459634 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0818034099197665 0.45869015366267 no 1528 0.467401522220512 506 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2567 aureobasidin a 60 nM 0.0812522311192606 0.458909277727991 no 1529 0.467620681182382 494 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_992 3909-8734 162 µM 0.0811234887763195 0.458960461732751 no 1530 0.467671872953423 502 4288319 SGTC_683 panaxydol 45 µM 0.0795396513903191 0.459590202283282 no 1531 0.468301697125898 496 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_741 4582-0002 126 µM 0.0789522024071046 0.459823800386598 no 1532 0.468535320638513 516 2912688 SGTC_590 k048-0076 22.4 µM 0.0774533519564375 0.460419878405976 no 1533 0.469131449744054 504 6832814 SGTC_1114 scopoletin 1.73284 µM 0.0771133939054903 0.46055508878926 no 1534 0.469266668966665 523 5280460 A coumarin with genotoxic properties. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0761045329241544 0.46095636649742 no 1535 0.469667966925229 519 6708784 An antioxidant flavonoid SGTC_606 k015-0008 38.6 µM 0.0748060978578405 0.461472881690513 no 1536 0.470184495012871 518 1970475 SGTC_2934 9036370 36.88 µM 0.0746281178304542 0.461543686917865 no 1537 0.470255300852694 506 6462800 SGTC_374 0880-0231 82.3 µM 0.0737615800030924 0.461888436274985 no 1538 0.470600049213329 518 6833587 SGTC_2585 alliin 100 µM 0.0733577404729242 0.46204911236413 no 1539 0.470760722583044 526 87310 A garlic compound which reacts with lipids. SGTC_841 0251-0215 91.2 µM 0.0727523208770459 0.46229000293588 no 1540 0.471001606392163 522 3888614 SGTC_1883 5-benzylidenerhodanine 20 µM 0.0720783541700186 0.462558184003073 no 1541 0.471269776140951 509 1273210 SGTC_2906 7926292 26.41 µM 0.072017778598027 0.462582288731751 no 1542 0.471293879656761 515 2966319 SGTC_235 0330-0087 5 mM 0.0705128427221746 0.463181189053193 no 1543 0.471892739490036 517 46494818 YHR062C RPP1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0703877956483315 0.463230956231877 no 1544 0.471942502408602 510 279621 SGTC_2836 9010338 19.48 µM 0.0703742993079069 0.463236327641771 no 1545 0.471947873350482 519 2994051 SGTC_1487 3970-0795 2.82 µM 0.0703715363501731 0.463237427272426 no 1546 0.471948972885129 501 3765103 SGTC_197 4544-0043 41.561 µM 0.0700822784749467 0.463352550682508 no 1547 0.472064085872641 500 896523 SGTC_330 1488-0319 80.1 µM 0.0690665976784152 0.463756811585738 no 1548 0.472468304353074 527 6846614 SGTC_1165 k072-0275 30.3 µM 0.0645625061995076 0.465549973690099 no 1549 0.474261169057877 522 6153523 YGL055W OLE1 SGTC_2396 5342950 42.78 µM 0.0645198381757086 0.46556696402241 no 1550 0.474278155720216 526 1886677 SGTC_1433 4060-0023 7.6 µM 0.0644286569921301 0.46560327242028 no 1551 0.474314456221749 515 3840627 SGTC_310 1273-0058 1.06 µM 0.0641582609061997 0.465710945974077 no 1552 0.474422105929423 510 2734232 SGTC_1833 st055984 71 µM 0.0638223406253044 0.465844715201789 no 1553 0.474555844637336 504 676288 SGTC_1616 st002734 56.1 µM 0.0630273752607734 0.46616129941478 no 1554 0.474872352673297 508 4026101 SGTC_84 0443-0269 128.823 µM 0.0629004949159205 0.46621182978418 no 1555 0.474922870370441 530 6150058 SGTC_2111 5486399 200 µM 0.0625679150638619 0.466344283006316 no 1556 0.47505528970441 510 689674 SGTC_3178 9107506 49.47 µM 0.0609159052773898 0.467002267236176 no 1557 0.475713091195054 511 8897194 SGTC_1540 guanosine 70.6 µM 0.060810586733998 0.467044217970625 no 1558 0.475755029466227 514 6802 Guanosine is a purine nucleoside SGTC_3300 9124615 50.48 µM 0.0606077514124697 0.467125012852744 no 1559 0.475835800070377 502 24824903 SGTC_2308 7584454 197.62 µM 0.0598370989782912 0.467431997215119 no 1560 0.476142688894344 509 893577 SGTC_1906 st060206 94.7 µM 0.0586021258414283 0.467923981014539 no 1561 0.476634508709236 517 5133468 SGTC_1628 st004252 77.7 µM 0.058532510631615 0.467951715517182 no 1562 0.476662233569038 521 692968 SGTC_2019 4016004 108 µM 0.0584245312449206 0.467994734507085 no 1563 0.476705237517775 510 45595336 SGTC_1994 st072947 40.9 µM 0.058324438426494 0.468034611821846 no 1564 0.476745100798432 518 5286565 YDL195W SEC31 SGTC_3151 9099821 49.47 µM 0.0561616426167723 0.468896354608613 no 1565 0.477606518833874 519 17174189 SGTC_1422 4031-0024 15.5 µM 0.0553532621306614 0.469218482772912 no 1566 0.477928515064465 527 782427 SGTC_345 1362-0200 395 µM 0.0553271832330517 0.469228875180566 no 1567 0.477938903120243 501 1419823 SGTC_41 0478-0632 82.643 µM 0.0552638044314411 0.469254131640074 no 1568 0.477964148978602 531 3750424 SGTC_628 1636-0253 16 µM 0.0531652588510806 0.470090471543716 no 1569 0.478800117935171 515 4456143 SGTC_1837 st055472 66.5 µM 0.0498819645464859 0.471399236401756 no 1570 0.4801082248084 504 676091 SGTC_1661 st013063 9.66 µM 0.0496392414862072 0.471496001484061 no 1571 0.4802049374892 524 721395 SGTC_1896 st058441 89 µM 0.0495646036399192 0.471525757286837 no 1572 0.480234677074378 524 688759 SGTC_723 4182-0001 115 µM 0.0493844603119062 0.471597575519186 no 1573 0.480306455962935 514 744821 YLR208W SEC13 SGTC_1558 st069300 45.6 µM 0.0491593532703744 0.471687320855831 no 1574 0.480396151734975 534 24208000 SGTC_1240 0356-0016 42.1 µM 0.048981814954766 0.471758102578666 no 1575 0.480466894053077 529 4305613 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0476520851351706 0.472288273066579 no 1576 0.480996760605458 525 6728940 SGTC_1605 st000082 49.1 µM 0.047494932661941 0.472350933872365 no 1577 0.48105938446495 522 1114022 SGTC_1623 st003709 20.3 µM 0.0468766272694288 0.472597475049327 no 1578 0.481305778174035 533 16192618 SGTC_2374 9071832 200 µM 0.0466059558308629 0.472705405049813 no 1579 0.481413642561997 527 17381698 SGTC_2702 st077768 96.8 µM 0.0461197284092643 0.472899292839091 no 1580 0.481607410870743 516 6484119 SGTC_1462 k081-0014 26.5 µM 0.0458290772999357 0.473015195790948 no 1581 0.481723241409625 521 3270634 SGTC_2865 9030313 51.95 µM 0.0457176716684337 0.473059621624281 no 1582 0.481767639290651 535 42562754 SGTC_1852 st056254 31.4 µM 0.0443081467877399 0.473621734330967 no 1583 0.48232938892813 527 442583 SGTC_3197 9113331 49.47 µM 0.0442671352170195 0.473638090367959 no 1584 0.482345734140103 516 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3235 9132602 49.47 µM 0.0432521529043269 0.474042894812945 no 1585 0.482750265975358 518 4912240 SGTC_165 k038-0023 64.381 µM 0.0417039704794314 0.474660406440582 no 1586 0.48336734436592 522 46368543 SGTC_3206 9114350 49.47 µM 0.0415715470204327 0.474713228015509 no 1587 0.483420127907265 529 17087243 SGTC_2202 7226349 200 µM 0.041559618236702 0.474717986236146 no 1588 0.483424882694257 520 844334 SGTC_1796 st049173 110.4 µM 0.0411236581955735 0.474891886908688 no 1589 0.483598657020835 532 94134 SGTC_1581 himbacine 57.9 µM 0.0408230385879899 0.475011804246766 no 1590 0.483718486264357 511 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2882 9058044 58.44 µM 0.0407131175338029 0.475055652385625 no 1591 0.483762301993559 518 18076804 SGTC_1611 st001856 99.4 µM 0.0404161238531559 0.475174126377393 no 1592 0.483880687887956 535 647478 SGTC_2648 atorvastatin 78.68 µM 0.0394906625711991 0.475543316923717 no 1593 0.484249598950015 530 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_59 0330-0160 1.33 µM 0.0390801171078926 0.475707100916476 no 1594 0.484413256553652 533 4293482 SGTC_2397 5161689 200 µM 0.0381975762087735 0.476059197761989 no 1595 0.484765076696255 525 2259942 SGTC_2676 harmalol 100 µM 0.0364788132081776 0.476744965600445 no 1596 0.485450286037242 528 5459187 A monoamine oxidase inhibitor SGTC_2197 6588183 93.1375 µM 0.0347381747543176 0.477439531697675 no 1597 0.486144260116963 529 884136 SGTC_661 1304-0007 33.6 µM 0.0344928707774077 0.47753742078012 no 1598 0.486242063631333 521 3117130 SGTC_308 4092-1169 104 µM 0.0335875895429247 0.477898686898569 no 1599 0.486603009397858 533 2268590 YDL196W YDL196W SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0310813738589248 0.478898923862014 no 1600 0.487602322000036 528 77254 SGTC_2380 9035439 200 µM 0.030225182940296 0.479240662579513 no 1601 0.487943732310893 529 6462575 SGTC_3306 9127676 59.7925 µM 0.0289106056459679 0.479765390542055 no 1602 0.488467943538084 531 41905287 SGTC_190 3970-0790 3.722 µM 0.0279828267470084 0.480135744840058 no 1603 0.488837924027188 535 2832352 SGTC_3213 9129884 49.47 µM 0.0279264442877049 0.480158252359859 no 1604 0.488860408586947 524 17190742 SGTC_919 tnp00227 403.569 nM 0.0269412111267339 0.480551561330147 no 1605 0.489253311854777 531 1269246 A methoxyflavone. YNL221C POP1 SGTC_306 1672-3436 11.6 µM 0.0268420030028253 0.480591166660781 no 1606 0.489292875861836 534 6797378 SGTC_417 st075190 100 µM 0.0265951903106545 0.480689698719185 no 1607 0.48939130474019 540 222757 SGTC_389 tpck 16.7 µM 0.0255074588851392 0.481123954611032 no 1608 0.489825099547104 520 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1205 4161-2785 76 µM 0.0252084637125405 0.481243326641016 no 1609 0.489944343018144 518 3498106 SGTC_2797 7859098 81.82 µM 0.0247285372028797 0.481434937934405 no 1610 0.490135746320298 535 972681 SGTC_1658 st012944 20 µM 0.0243588224233563 0.481582549975838 no 1611 0.490283196758512 529 24207260 SGTC_2241 6772625 37.8075 µM 0.0243186077931765 0.481598606191101 no 1612 0.49029923532367 533 2285411 SGTC_77 0828-0286 12.516 µM 0.0239793719061903 0.481734051725999 no 1613 0.490434531405059 506 745345 SGTC_3150 9097574 49.47 µM 0.0231479905669853 0.482066003350666 no 1614 0.490766112495363 535 17217476 SGTC_2966 9084041 48.03 µM 0.0224916809391386 0.482328061623732 no 1615 0.491027873985894 508 17741380 SGTC_231 b-estradiol 524 µM 0.0222143927299697 0.482438782503537 no 1616 0.491138468342891 537 450 A steroid. SGTC_2915 7971052 15.16 µM 0.0213125167593868 0.482798909918421 no 1617 0.491498179588709 542 5741558 SGTC_684 1140-0066 328 µM 0.0183832071369485 0.483968705644302 no 1618 0.492666574471807 536 6813534 SGTC_536 3852-0578 10.6 µM 0.018211687912001 0.484037204811937 no 1619 0.492734989288975 531 2869208 SGTC_3345 9148410 3.559 µM 0.0175221200110643 0.484312600408002 no 1620 0.493010043168703 543 4903596 SGTC_311 1315-0136 58 µM 0.017463623015025 0.484335962942409 no 1621 0.493033376523413 536 6759207 SGTC_1004 4084-0029 199 µM 0.0172688874454402 0.484413736834957 no 1622 0.493111053061503 540 716894 YLR208W SEC13 SGTC_2932 9016711 44.54 µM 0.0165270020448605 0.484710037960376 no 1623 0.4934069802556 539 7117328 SGTC_3331 9141060 1.957 µM 0.0159201444518453 0.484952416703064 no 1624 0.493649049544984 536 4906567 YPR165W RHO1 SGTC_1172 0370-0043 85 µM 0.0157745294740604 0.485010576112468 no 1625 0.493707134222135 536 376585 SGTC_800 3448-7362 155 µM 0.0157520313028529 0.485019562032156 no 1626 0.493716108578814 543 15991913 SGTC_1271 0832-2808 169 µM 0.0152175949795054 0.48523302169204 no 1627 0.493929292261778 538 3663794 SGTC_3215 9129942 49.47 µM 0.0135270763274377 0.48590826073672 no 1628 0.494603641895817 541 17682944 SGTC_1259 0671-0132 43 µM 0.0132154307126153 0.48603274492442 no 1629 0.494727959393683 539 X1259 SGTC_2099 5377090 177.372 µM 0.0131471336279248 0.486060025795708 no 1630 0.494755203621496 539 2243829 SGTC_2962 9082311 13.18 µM 0.0118652038381273 0.486572097121824 no 1631 0.495266579587887 542 16459453 SGTC_2363 9053361 176 µM 0.0101069682746153 0.487274466289784 no 1632 0.495967971674522 539 6469797 YMR079W SEC14 SGTC_1255 0566-0045 221 µM 0.00948742969888071 0.48752196528035 no 1633 0.496215119941209 540 2788469 SGTC_106 0092-0003 11.579 µM 0.00913630721288702 0.487662237072806 no 1634 0.496355191472756 544 1072148 SGTC_360 0957-0399 1.01 µM 0.00905861113617582 0.487693276499244 no 1635 0.496386186440113 542 6752301 YPR165W RHO1 SGTC_3241 9133421 49.47 µM 0.00883660285150087 0.487781968772811 no 1636 0.496474751385976 545 17018221 SGTC_368 fentichlor 4.58 µM 0.00823844482911729 0.488020935800303 no 1637 0.49671337321126 540 7329 A pesticide. SGTC_665 3914-0008 307 µM 0.00729270258101985 0.488398773151439 no 1638 0.497090658390228 541 1069549 SGTC_1499 4480-0877 67.3 µM 0.00726148747526817 0.488411244205295 no 1639 0.497103111085972 542 2861909 SGTC_2045 5106652 78.05 µM 0.00700415428846995 0.488514054347885 no 1640 0.497205769562535 544 673349 SGTC_1853 st056710 91.2 µM 0.00511949891948965 0.489267037526608 no 1641 0.497957624348079 544 269167 SGTC_1473 k844-0725 134 µM 0.00421909809056794 0.489626791596997 no 1642 0.498316828380143 545 54682906 SGTC_3057 9095946 49.47 µM 0.00263004485943067 0.490261716315841 no 1643 0.498950765115838 546 24540043 SGTC_35 0133-0054 64.071 µM 0.00253281225851762 0.490300567551079 no 1644 0.498989555182116 546 99677 SGTC_1937 st074714 47.2 µM 0.00117155678247169 0.490844493965119 no 1645 0.499532616572498 543 17250970 SGTC_1952 st077036 64.1 µM 0.000381836884216177 0.491160055761725 no 1646 0.499847669126371 544 2937007 SGTC_2390 9097792 176.6 µM -0.00069885317103837 0.491591894374302 no 1647 0.499721197944974 548 4497149 SGTC_429 1112-0049 25.5 µM -0.00468231797004898 0.493183749185539 no 1648 0.498132032217052 552 2836170 SGTC_1265 0819-1001 68.8 µM -0.00527636123692982 0.493421148079535 no 1649 0.497895046182903 551 3106768 SGTC_1694 st024011 44.9 µM -0.00596179850478923 0.49369507386098 no 1650 0.497621600598472 555 2787533 SGTC_718 1130-0073 349 µM -0.00598076046378254 0.493702651795612 no 1651 0.497614036006174 554 6740020 SGTC_2642 cholecalciferol 100 µM -0.00702673949195699 0.494120669048151 no 1652 0.497196759591675 550 9821465 A vitamin D precursor, similar to steriods. SGTC_3205 9113483 49.47 µM -0.00762701418152238 0.494360567029137 no 1653 0.496957291069543 552 17018033 SGTC_3204 9114183 49.47 µM -0.00899882673712355 0.494908815323213 no 1654 0.496410035992499 554 17027248 SGTC_49 0717-0965 32.132 µM -0.00909432294707828 0.494946980990606 no 1655 0.496371940075671 555 5889349 YGL099W LSG1 SGTC_1030 k029-0042 36.7 µM -0.00976141821468216 0.495213591125729 no 1656 0.496105819400599 553 6080581 SGTC_2432 5630864 12.22 µM -0.0109234923608516 0.495678028694639 no 1657 0.495642243710984 557 5714970 SGTC_110 0850-0284 111.64 µM -0.0116433413285046 0.495965728379489 no 1658 0.495355083809018 554 3906265 SGTC_1799 st045822 46.1415 µM -0.011653659543786 0.495969852242488 no 1659 0.495350967715944 553 3674992 SGTC_160 3453-0671 289.699 µM -0.012285642778673 0.496222436677307 no 1660 0.495098860947875 558 5322268 SGTC_1760 st045453 10.4495 µM -0.0129728296218731 0.496497086026875 no 1661 0.494824734929074 553 3323419 YIL048W NEO1 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0132045177256493 0.496589685658657 no 1662 0.494732312665742 556 688798 SGTC_2086 5274770 176.623 µM -0.0140047643364291 0.496909524530275 no 1663 0.494413090009702 556 689278 SGTC_2276 7947513 42.08 µM -0.0153993845358293 0.497466924520243 no 1664 0.493856777219168 579 2105100 SGTC_326 k292-0812 17.5 µM -0.0155374358851836 0.497522100991012 no 1665 0.493801709287581 556 3579357 SGTC_501 nsc-95397 161 µM -0.0161182800449355 0.497754253743822 no 1666 0.493570015021156 554 262093 SGTC_1632 st005650 90 µM -0.0163930417200388 0.497864071213561 no 1667 0.493460415453876 560 2759605 SGTC_1354 1498-1681 81 µM -0.0165460494111085 0.497925225801084 no 1668 0.493399382494774 557 5754243 SGTC_154 3389-1638 511.116 µM -0.0172653873433997 0.498212733641843 no 1669 0.493112449192046 561 5238686 SGTC_1071 trifluoperazine 6.31 µM -0.0177254569843576 0.498396616598664 no 1670 0.492928936049857 558 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2183 6420625 130.508 µM -0.0187131067483402 0.498791366542755 no 1671 0.492534986206506 555 2897619 SGTC_3336 9143619 71.43 µM -0.0187877428719383 0.498821197621514 no 1672 0.492505215934917 561 45595730 SGTC_1817 st052116 64.4 µM -0.0202032767010151 0.499386968968305 no 1673 0.491940606995329 559 4361398 SGTC_1780 st038448 24.544 µM -0.0204186122579962 0.499473036060747 no 1674 0.491854718255201 565 728868 YDL195W SEC31 SGTC_1298 1079-1278 263 µM -0.0207584642981954 0.499608870977086 no 1675 0.491719165640539 559 2840950 SGTC_3006 9075424 71.4286 µM -0.0212738463767339 0.499814863293998 no 1676 0.491513603342389 552 7465181 SGTC_2036 5160441 105 µM -0.0217370486905989 0.5 no 1677 0.491328855083182 562 134534 YIL048W NEO1 SGTC_1923 st058458 19.1 µM -0.0219299222608505 0.499922910621424 no 1678 0.491251927999154 559 3534982 SGTC_971 1315-0384 26.7 µM -0.0221884731761657 0.499819570757927 no 1679 0.491148806200694 564 6769120 SGTC_929 2805-0021 398 µM -0.0231902045438675 0.499419190287815 no 1680 0.490749276074724 591 3098024 SGTC_142 0335-0849 62.6745 µM -0.023929328195486 0.499123771444434 no 1681 0.490454490230008 559 3889043 YPR107C YTH1 SGTC_2329 6138490 200 µM -0.0240826274537591 0.499062499627514 no 1682 0.490393350294001 581 720019 SGTC_648 0375-0473 33.3 µM -0.0243305478560101 0.498963408957423 no 1683 0.490294473336782 561 1713139 SGTC_981 1488-1094 54.9 µM -0.0246578069513993 0.498832607707363 no 1684 0.490163955006638 556 3449522 SGTC_551 k048-0028 34.9 µM -0.0266335408706254 0.49804293544608 no 1685 0.489376010497944 566 6836383 SGTC_2737 bleomycin 30.5 nM -0.0270890372271722 0.497860881117919 no 1686 0.489194359289435 559 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2333 9017922 200 µM -0.0271093520606938 0.497852761626475 no 1687 0.489186257818694 564 3163164 SGTC_300 r073-0011 5.04 µM -0.0271781311763606 0.497825271797131 no 1688 0.489158829027842 555 2735780 SGTC_2152 5568786 200 µM -0.0273290634669097 0.497764946793422 no 1689 0.489098638113531 565 5399883 SGTC_1207 2099-0101 141 µM -0.0288504852938843 0.49715686411561 no 1690 0.488491918087937 563 5837381 SGTC_2420 aureobasidin a 50 nM -0.0290113302312434 0.497092577887731 no 1691 0.488427777090448 584 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3167 9103034 49.47 µM -0.0294434945616824 0.49691985157014 no 1692 0.488255442091882 558 5127859 SGTC_475 α-linolenic acid 10 µM -0.0296581851911655 0.496834044789389 no 1693 0.488169830311237 572 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1139 k015-0024 46.9 µM -0.0296915520569701 0.496820708853193 no 1694 0.488156524717432 565 2766652 SGTC_3266 9136860 49.47 µM -0.0303308580204821 0.496565194292355 no 1695 0.487901593373484 564 4871271 YPR165W RHO1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0304516893218998 0.49651690120658 no 1696 0.487853410915091 564 641818 YHR062C RPP1 SGTC_2128 5255449 168.493 µM -0.03057513022917 0.496467565182854 no 1697 0.487804188038343 562 736008 SGTC_321 4534-3890 65.3 µM -0.0307274932604328 0.496406669835553 no 1698 0.487743432529954 565 699746 SGTC_806 3966-4455 5.86 µM -0.0308791311811155 0.496346064378299 no 1699 0.487682966445387 586 714982 SGTC_1649 st011737 51.3 µM -0.0326866387410429 0.495623660789958 no 1700 0.486962239469411 565 1761035 SGTC_1199 1638-0010 4.46 µM -0.0334391843886183 0.49532289619797 no 1701 0.486662181249807 560 3111136 SGTC_974 1326-0144 138 µM -0.0348548548229 0.494757112557242 no 1702 0.486097739676294 569 5411856 SGTC_2699 st077704 54.6 µM -0.0356704710664284 0.494431149931173 no 1703 0.485772558118419 569 645852 SGTC_40 0327-0103 19.753 µM -0.0371614433814467 0.49383528969726 no 1704 0.485178140543862 569 409036 SGTC_1241 0364-0022 50.8 µM -0.0374707743178918 0.493711668688883 no 1705 0.485054821245633 569 4563895 SGTC_874 0599-0792 117 µM -0.0382448852704046 0.493402305678234 no 1706 0.484746216892148 563 765305 SGTC_1358 1509-0022 2.48 µM -0.0390720832425833 0.493071731545866 no 1707 0.484416459156172 567 3258434 SGTC_2744 captopril 92.04 µM -0.0402368544027179 0.492606260748628 no 1708 0.483952147922522 568 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1672 st016598 6.51 µM -0.0405515319167535 0.492480509685059 no 1709 0.483826712135967 606 4665860 YNL267W PIK1 SGTC_1567 st069303 68.4 µM -0.0408417507525055 0.492364533432305 no 1710 0.483711027411381 566 5581319 SGTC_354 2783-3500 4.88 µM -0.0417366304349127 0.492006928798427 no 1711 0.483354326263282 564 6740761 SGTC_2541 muurolladie-3-one 83.07 µM -0.0426486076015888 0.49164249841636 no 1712 0.482990823726079 575 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2735 sertaconazole 140 nM -0.0426770339845751 0.491631139210023 no 1713 0.482979493555834 570 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1481 3346-2004 36 µM -0.0434981741167757 0.491303013895288 no 1714 0.482652209996978 575 2770522 SGTC_2774 tamoxifen 10.92 µM -0.0435572294878554 0.49127941575733 no 1715 0.48262867262081 568 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1005 4092-0690 4.4 µM -0.0438097393596626 0.491178514818247 no 1716 0.482528031826556 578 1529343 SGTC_236 1509-0011 5.31 µM -0.044705323675592 0.49082065103486 no 1717 0.482171095131564 576 3107280 SGTC_100 0086-0128 49.5915 µM -0.0450677375465143 0.490675837274127 no 1718 0.482026658495067 577 93297 SGTC_251 melphalan 456.522 µM -0.04508456675453 0.490669112669112 no 1719 0.482019951429814 578 460612 A DNA alkylator. SGTC_3032 9089427 49.47 µM -0.0468150202207783 0.489977673596191 no 1720 0.481330328877082 559 17173707 SGTC_1997 st073024 93.8 µM -0.0474128589731637 0.489738801445044 no 1721 0.4810920902841 570 686268 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0483350692836224 0.489370330805153 no 1722 0.48072460297933 578 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1626 st003712 1.76 µM -0.0490570662582694 0.489081862047046 no 1723 0.480436909173529 585 24207035 SGTC_1885 st057546 99.9 µM -0.049719370040483 0.488817248298442 no 1724 0.480173010244114 574 702008 SGTC_1991 st073000 8.92 µM -0.0516237659026834 0.48805640273384 no 1725 0.479414241066954 596 4301969 YIL048W NEO1 SGTC_1253 0550-0034 176 µM -0.0516913424234853 0.488029405297257 no 1726 0.479387317881923 574 5969915 SGTC_2939 9044578 71.43 µM -0.0517412165798947 0.488009480151927 no 1727 0.479367447562325 572 2653634 SGTC_2837 9008476 45.46 µM -0.0543812800206051 0.486954796533885 no 1728 0.478315696580919 587 2992805 SGTC_2288 7946289 167.31 µM -0.0548238469716842 0.48677800340764 no 1729 0.478139400917112 586 1246052 SGTC_598 3937-0236 20.2 µM -0.0551474881591747 0.486648719442655 no 1730 0.478010481800239 564 1379313 SGTC_1014 4130-3005 69.3 µM -0.0557558262509292 0.486405712275901 no 1731 0.477768162856524 588 743608 SGTC_3003 9075612 71.4286 µM -0.0573225696584409 0.485779883299154 no 1732 0.477144120961399 593 6501993 SGTC_774 k060-0086 136 µM -0.0579870913498986 0.485514453429634 no 1733 0.476879455417701 572 5911235 SGTC_904 1141-0088 396 µM -0.0583612641054931 0.485365000439272 no 1734 0.476730434460617 605 1378119 SGTC_2800 7887935 81.82 µM -0.0598768220833242 0.484759673837145 no 1735 0.476126870031987 582 2961002 SGTC_2623 humulene 100 µM -0.0602367931090193 0.484615903491489 no 1736 0.475983521121006 587 6187145 An anti-inflammatory. SGTC_725 1497-0963 19 µM -0.0602726167448874 0.484601595847632 no 1737 0.475969255478172 567 3549977 SGTC_3174 9107204 49.47 µM -0.0607181730947387 0.484423646238157 no 1738 0.475791829173489 590 3938802 SGTC_1173 0443-0020 122 µM -0.0614697843742046 0.484123469183045 no 1739 0.475492538731162 578 5331295 SGTC_1942 st076330 65.2 µM -0.0624083682039387 0.48374863204688 no 1740 0.47511881554449 612 24208414 SGTC_2158 5657123 3.6195 µM -0.0639680632500119 0.483125777015757 no 1741 0.474497828270854 617 2858827 SGTC_2614 arthonioic acid 13.39 µM -0.0639759179091098 0.48312264040684 no 1742 0.474494701120592 585 6710684 SGTC_319 1348-1596 45.5 µM -0.0640331129794294 0.483099800673395 no 1743 0.47447193027788 575 5380505 SGTC_738 1315-0003 72.4 µM -0.0646639513380655 0.482847891400514 no 1744 0.474220782694927 593 6251474 SGTC_2760 etidronate 98.04 µM -0.0649904632994267 0.482717509826158 no 1745 0.474090796693658 577 3305 A chelator and antioxidant. SGTC_1302 1159-0335 255 µM -0.0651153718082462 0.482667632300625 no 1746 0.474041070736928 590 649284 SGTC_480 am 92016 50 µM -0.066100881009624 0.482274115760388 no 1747 0.473648754721553 617 2129 K+ channel blocker. SGTC_114 0364-0001 490.298 µM -0.0673476150741547 0.48177631620257 no 1748 0.473152485779123 586 4003655 SGTC_1708 st033234 31.827 µM -0.0679424550505966 0.481538816752742 no 1749 0.472915721285581 583 674664 SGTC_2114 5491910 81.25 µM -0.0679651418684605 0.481529758804157 no 1750 0.472906691427487 581 2849228 SGTC_2011 4012611 177 µM -0.0692628758563848 0.481011640996623 no 1751 0.472390187758473 575 2049887 SGTC_3072 9116419 49.47 µM -0.0698043563588464 0.480795465377071 no 1752 0.472174689882761 580 17170162 SGTC_1522 st012842 45.6 µM -0.0703227632582245 0.480588506738174 no 1753 0.471968382447925 570 3491067 YOR116C RPO31 SGTC_1932 st074806 40.9 µM -0.0706853085459447 0.480443774348703 no 1754 0.47182410683485 572 17251235 SGTC_249 wiskostatin 11.211 µM -0.0708792469487812 0.48036635288957 no 1755 0.471746930181209 588 2775510 A n-wasp and actin depolymerizer. SGTC_1446 4239-0190 62 µM -0.0708949184611782 0.480360096753219 no 1756 0.471740693840755 611 1340085 SGTC_504 lovastatin 124 µM -0.0712002775163066 0.480238197049066 no 1757 0.471619180276503 605 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0712223899601817 0.480229369806347 no 1758 0.471610381026762 607 689007 SGTC_2014 4013930 200 µM -0.0720623364856807 0.47989407207616 no 1759 0.471276149698397 598 64556 SGTC_938 3126-1755 342 µM -0.072841551335271 0.479583030501024 no 1760 0.470966102788224 572 1777771 SGTC_516 3992-2719 87.3 µM -0.0739106720250599 0.47915628659377 no 1761 0.470540732014693 579 5350887 YDR037W KRS1 SGTC_1081 sertraline 6 µM -0.0743593717813271 0.478977193335884 no 1762 0.470362217943648 578 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2675 theaflavin digallate 100 µM -0.0762654937229463 0.478216434814331 no 1763 0.469603938941269 585 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1495 4469-0029 237 µM -0.0763795582979233 0.478170912620407 no 1764 0.469558566103569 591 793680 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0766768643545673 0.47805226166223 no 1765 0.46944030495749 581 5282309 SGTC_2649 anisomycin 9.56 µM -0.0767716360386455 0.478014439931192 no 1766 0.469402607643889 608 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2815 7968870 71.43 µM -0.0767923427652809 0.478006176263027 no 1767 0.469394371169924 602 2977326 YHR190W ERG9 SGTC_3262 9137218 49.47 µM -0.0786458148215595 0.477266528883732 no 1768 0.468657172705211 576 17650664 SGTC_571 k831-0106 44.2 µM -0.07896522639244 0.477139072199993 no 1769 0.468530140991495 582 4783639 SGTC_2776 terbinafine 19.92 µM -0.0790828429368716 0.47709213956471 no 1770 0.468483365060451 572 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_880 0833-0487 87.2 µM -0.0796715294099497 0.476857240261078 no 1771 0.468249251845773 570 76075 SGTC_1772 st048439 82.2 µM -0.0797156923256059 0.476839618575642 no 1772 0.468231689250788 580 2927068 YDL195W SEC31 SGTC_2711 st079103 59.1 µM -0.0802987126221462 0.476606988731279 no 1773 0.467999841044055 597 54693780 SGTC_2446 5162541 200 µM -0.0807764803902517 0.476416361442301 no 1774 0.467809856432176 583 1549321 SGTC_3053 9095903 49.47 µM -0.0830919148740376 0.475492590270865 no 1775 0.466889227305729 598 17174018 SGTC_2808 7946468 45.46 µM -0.0836312996697968 0.475277414781668 no 1776 0.466674790282135 616 2970879 SGTC_1706 st031321 9.9705 µM -0.0853652132693558 0.474585757925174 no 1777 0.465985523985523 588 6103185 SGTC_3120 9124077 49.47 µM -0.0862010517822873 0.474252369789129 no 1778 0.465653297310159 598 18774327 YGL155W CDC43 SGTC_68 0986-0284 82.829 µM -0.0866911647706808 0.474056888417634 no 1779 0.465458499734641 576 423278 YIL048W NEO1 SGTC_3170 9103054 49.47 µM -0.0868711865555434 0.473985088366004 no 1780 0.465386951355674 613 16432970 SGTC_2561 acetosyringone 100 µM -0.0868872993440996 0.473978661968 no 1781 0.465380547496898 586 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_875 0709-0210 25.7 µM -0.088627647259079 0.473284584690962 no 1782 0.464688917602495 588 6251364 SGTC_3274 9138298 49.47 µM -0.0893346437229758 0.473002646769694 no 1783 0.464407981208357 596 17015756 SGTC_1009 4106-0057 9.87 µM -0.0899402622604217 0.472761147355351 no 1784 0.464167343064625 586 2928005 SGTC_3230 9131665 49.47 µM -0.0900099094169813 0.472733375154317 no 1785 0.464139670109603 591 15943720 SGTC_2690 usnic acid 100 µM -0.0901735070908324 0.472668140170098 no 1786 0.46407466841026 608 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2181 6316240 54.2555 µM -0.0935859689934283 0.471307582159233 no 1787 0.462719027906795 596 12779990 SGTC_1249 0481-0015 10.2 µM -0.0952032902552767 0.47066286766219 no 1788 0.462076678307109 587 4227577 SGTC_1590 st077108 57.8 µM -0.095412530276482 0.470579463671021 no 1789 0.461993581881654 588 5489485 SGTC_2596 sinensetin 100 µM -0.0964697029080553 0.470158089825839 no 1790 0.461573767625388 597 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1539 benzyladenosine 56 µM -0.0969712929769167 0.469958174879115 no 1791 0.461374595934855 596 92208 A nucleotide analog. SGTC_689 0833-0039 98 µM -0.0974437569459687 0.469769875425505 no 1792 0.46118699851291 621 5374726 SGTC_1011 4112-3381 17.4 µM -0.0983667532392941 0.469402036868251 no 1793 0.460820536843353 634 2877139 SGTC_2564 betulinic acid 100 µM -0.098937877088955 0.469174441891307 no 1794 0.460593797429969 638 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_495 decylubiquinone 155 µM -0.100151022220204 0.468691032559731 no 1795 0.46011221452084 637 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1791 st048313 56.1 µM -0.100371258486395 0.468603278602339 no 1796 0.460024793460031 577 1204976 SGTC_2170 morpholine 200 µM -0.101025735265053 0.468342508920086 no 1797 0.459765015449491 605 121171 Reacts with secondary amines. SGTC_1425 4048-4433 7.33 µM -0.102845668815074 0.467617446467926 no 1798 0.459042729469258 598 23734946 SGTC_1617 st002906 78 µM -0.103042420248858 0.467539066988318 no 1799 0.458964651814781 615 5150859 SGTC_969 1313-0238 134 µM -0.104443628837968 0.466980906868771 no 1800 0.458408650588702 591 5212874 SGTC_2466 5983409 37.09 µM -0.104456032415566 0.466975966292141 no 1801 0.458403729196146 614 2879657 SGTC_1074 carmofur 3.8 µM -0.106762510571241 0.466057342216183 no 1802 0.457488694832305 601 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1349 flufenamic acid 69 µM -0.107372991314567 0.465814230019099 no 1803 0.457246540211666 607 3371 A non-steroidal anti-inflammatory. SGTC_999 SEC7.066 22.7 µM -0.110098294588297 0.464729087347131 no 1804 0.456165710328937 592 740511 YDR170C SEC7 SGTC_898 1000-0849 28.3 µM -0.110335011589015 0.464634845249992 no 1805 0.45607184576379 590 6751807 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.112421340425883 0.463804319539267 no 1806 0.455244667686007 592 688669 SGTC_405 ebelactone b 50 µM -0.112846284673256 0.463635176963153 no 1807 0.455076211406189 588 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1035 k081-0041 55.2 µM -0.113306283487586 0.463452088860954 no 1808 0.454893867910541 593 731709 SGTC_646 4092-0839 27.3 µM -0.113636511682211 0.463320656655139 no 1809 0.454762971336842 593 877796 SGTC_2764 methyldopa 94.69 µM -0.113729939271192 0.463283472809013 no 1810 0.454725939195687 620 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1010 4112-3296 15.2 µM -0.114636444416808 0.46292270370906 no 1811 0.454366645826592 586 704384 SGTC_1442 4112-3290 3 µM -0.114961562187262 0.462793321405002 no 1812 0.454237794459861 598 704353 SGTC_688 0527-0193 473 µM -0.115296849563082 0.462659896176531 no 1813 0.454104917697814 598 4007154 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.117135871869788 0.461928145429935 no 1814 0.453376191875005 614 390807 SGTC_1484 3473-2379 286 µM -0.118201258706763 0.461504284609135 no 1815 0.452954096323435 596 671917 SGTC_1925 st057770 10.1 µM -0.118330108061817 0.461453025250379 no 1816 0.452903051098059 611 5989122 SGTC_1309 pyrazolanthrone 13.4 µM -0.121184306670506 0.460317722428761 no 1817 0.451772526982702 619 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3020 9089140 49.47 µM -0.121269626567069 0.460283790017537 no 1818 0.451738738460701 598 17217859 SGTC_864 0469-0573 172 µM -0.121739201678907 0.460097041390132 no 1819 0.451552782836649 630 689425 SGTC_2358 9037157 4 µM -0.12276418198018 0.459689440399824 no 1820 0.451146919148921 593 2388925 SGTC_1224 0823-0416 294 µM -0.123194197305944 0.459518450022943 no 1821 0.450976660223671 623 3598164 SGTC_1891 st059073 26.2 µM -0.125009728004653 0.458796609183328 no 1822 0.450257924461368 590 688754 SGTC_352 k048-0007 5.11 µM -0.125440978565494 0.458625167201907 no 1823 0.450087224051063 633 6811911 SGTC_2343 7990716 14.84 µM -0.126055895965448 0.458380722501667 no 1824 0.449843839412582 583 6456862 SGTC_211 3455-0679 143.504 µM -0.128078072728196 0.457576969274545 no 1825 0.449043594272827 614 748649 SGTC_2499 avocadenofuran 51.48 µM -0.129536979237466 0.456997206224372 no 1826 0.448466383114784 647 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3096 9117468 49.47 µM -0.129688804790159 0.456936876651788 no 1827 0.448406320121648 612 41316311 SGTC_230 MPP+ 141.667 µM -0.130480721451776 0.456622215876132 no 1828 0.448093052896942 622 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_161 4065-0411 162.148 µM -0.130700886225518 0.456534740258921 no 1829 0.448005965626591 637 1906281 YLR208W SEC13 SGTC_2782 7736369 71.43 µM -0.131209719159944 0.456332579403391 no 1830 0.447804703826197 612 2950836 YOL077C BRX1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.131272599895808 0.456307597481523 no 1831 0.447779833156225 619 521171 SGTC_2453 5731132 22.18 µM -0.131444136641679 0.456239448432647 no 1832 0.447711987764838 630 1362040 SGTC_2389 9091542 195.52 µM -0.132352283385585 0.45587867646316 no 1833 0.447352827452279 608 3626624 YOL127W RPL25 SGTC_1003 4049-0218 100 µM -0.133592349871638 0.455386104279341 no 1834 0.446862466939814 596 295161 SGTC_1343 1487-0095 224 µM -0.134035894139856 0.455209938749408 no 1835 0.446687095548457 637 4560101 YGL055W OLE1 SGTC_2536 dehydroabietamide 32.04 µM -0.1342469597334 0.455126111465473 no 1836 0.446603646732712 621 3983547 SGTC_1411 3909-8223 150 µM -0.135172212001049 0.454758659829476 no 1837 0.446237858517989 604 X1411 SGTC_94 0334-0113 514.748 µM -0.135238758320611 0.454732233331869 no 1838 0.446211551928862 604 6795178 SGTC_2817 7995342 71.43 µM -0.136368066784303 0.454283799392833 no 1839 0.445765158417026 635 18879975 SGTC_2013 4024628 200 µM -0.138653346086233 0.453376523068734 no 1840 0.444862043158564 622 5230760 SGTC_2368 9071271 200 µM -0.14029244926177 0.452725934000801 no 1841 0.444214464970859 636 27209959 SGTC_887 0885-0007 9.62 µM -0.140385588379068 0.452688969229849 no 1842 0.444177671948894 620 5719458 SGTC_3056 9094900 49.47 µM -0.141524130853044 0.4522371411753 no 1843 0.443727949114516 616 25236784 SGTC_104 0074-0074 590.992 µM -0.14231854426365 0.45192191657388 no 1844 0.443414199707009 632 3943124 SGTC_2571 chrysanthemic acid 100 µM -0.142382159398882 0.451896675287354 no 1845 0.443389076774553 666 2743 An insecticide. SGTC_1297 1068-0111 14.1 µM -0.145731036118076 0.450568181137063 no 1846 0.442066859819198 599 767057 SGTC_561 1550-0330 72.9 µM -0.148075360137046 0.449638520005018 no 1847 0.441141647410269 640 6812934 SGTC_1105 epirubicin 18.1 µM -0.149015083413731 0.449265942248739 no 1848 0.440770865504466 622 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3267 9137951 49.47 µM -0.149492448087308 0.449076695707639 no 1849 0.440582533981879 592 16643986 SGTC_259 usnic acid 108.925 µM -0.1495939630949 0.449036452571143 no 1850 0.440542485669819 664 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2857 9024691 58.44 µM -0.149924528713046 0.448905411569833 no 1851 0.440412079661029 656 16478292 SGTC_1091 telmisartan 47.6 µM -0.15082801913388 0.44854728335005 no 1852 0.440055691516918 625 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1351 1496-0003 46.5 µM -0.151543953046441 0.448263529094898 no 1853 0.439773320828257 612 3891978 SGTC_2483 5729050 27.16 µM -0.152634498485168 0.447831351692791 no 1854 0.439343258948538 641 2865180 SGTC_2226 7298446 200 µM -0.153395614797028 0.447529761972923 no 1855 0.439043151423738 629 3283010 SGTC_1287 0971-0001 34.6 µM -0.154187241879709 0.447216114649061 no 1856 0.438731050700902 604 4665869 SGTC_270 tamoxifen 5.46 µM -0.154921271670003 0.446925317201007 no 1857 0.438441691869302 623 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1033 k072-0102 21.3 µM -0.155036407050059 0.446879707093953 no 1858 0.438396307811221 610 5965931 SGTC_869 0564-0080 44.1 µM -0.155069348073398 0.446866657858176 no 1859 0.438383323269385 610 6843321 SGTC_2967 9089538 49.85 µM -0.155635631314452 0.446642339786398 no 1860 0.438160118715134 620 728216 SGTC_118 0083-0097 135.343 µM -0.155704046504248 0.446615240079753 no 1861 0.438133153713477 620 5207356 SGTC_9 0092-0002 10.449 µM -0.156946857604486 0.446122997952942 no 1862 0.437643365201538 618 759368 SGTC_593 1203-0218 61.7 µM -0.157367943683943 0.445956236526003 no 1863 0.437477437939414 631 3666956 SGTC_3013 9080133 71.4286 µM -0.15940938520053 0.445147906754271 no 1864 0.436673172570091 614 17050193 SGTC_1387 3342-1166 1.8 µM -0.160155324485641 0.444852601120942 no 1865 0.436379360468324 612 3418228 SGTC_1825 st052143 62.6 µM -0.160724435341466 0.44462731965486 no 1866 0.436155221508254 638 674173 SGTC_1223 0764-0573 147 µM -0.161444131549999 0.444342454878551 no 1867 0.43587180528719 610 1609797 SGTC_1130 3454-2858 15.9 µM -0.161832017877779 0.444188936523292 no 1868 0.435719069376796 606 715628 YIL048W NEO1 SGTC_1813 st051246 8.6015 µM -0.162037361450553 0.44410766865941 no 1869 0.435638216223727 607 5291959 SGTC_807 1315-0151 48 µM -0.162454514700614 0.443942581111618 no 1870 0.435473972203865 657 4011080 SGTC_2925 9010536 32.5 µM -0.162769602049869 0.443817892382452 no 1871 0.435349921544975 616 2994177 SGTC_1729 st035615 45.989 µM -0.163295297814262 0.443609872497536 no 1872 0.435142968006464 608 17385451 SGTC_2678 equilin 100 µM -0.163669030807826 0.44346199432592 no 1873 0.434995849287386 607 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1212 0520-0165 585 µM -0.16411232732478 0.443286601561846 no 1874 0.434821358793106 704 5403258 SGTC_2248 tofa 1.1 µM -0.164115108872263 0.443285501061958 no 1875 0.434820263959677 629 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_826 1683-5028 118 µM -0.164781850428367 0.443021722048427 no 1876 0.434557845003428 647 722377 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.165511033581762 0.442733268548186 no 1877 0.434270883029697 619 688801 SGTC_671 0560-0003 407 µM -0.166204145004953 0.442459112597703 no 1878 0.433998148787989 633 3238678 SGTC_1187 1391-0724 117 µM -0.166384540327755 0.442387762853491 no 1879 0.433927169704013 623 6997986 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.167763418543514 0.441842452475714 no 1880 0.433384701164023 630 688667 SGTC_303 1348-1668 34.2 µM -0.168500686769431 0.441550927266758 no 1881 0.433094701715858 623 5380509 SGTC_1824 st053723 68.6 µM -0.169586459720272 0.441121656560041 no 1882 0.432667685937724 645 675225 SGTC_329 k048-0121 21.3 µM -0.170178364198258 0.440887670568785 no 1883 0.43243493319437 623 6832902 SGTC_147 4466-0538 29.23 µM -0.171482073223009 0.440372373734434 no 1884 0.431922362576089 654 6742687 YHR072W ERG7 SGTC_2741 miltefosine 3.04 µM -0.173010354353889 0.439768442382461 no 1885 0.431321644380365 614 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2667 digitoxin 100 µM -0.173302121369209 0.439653160603379 no 1886 0.431206978155814 618 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1157 4092-0394 27.6 µM -0.173339246843364 0.439638492106005 no 1887 0.431192388032625 625 3659885 SGTC_335 4077-0256 27.6 µM -0.173372101596784 0.439625511065109 no 1888 0.431179476359352 652 3121989 SGTC_1237 0330-0133 46.1 µM -0.175426473054952 0.438813950398523 no 1889 0.430372270311855 655 X1237 YHR072W ERG7 SGTC_1954 st077032 68.9 µM -0.176000633140659 0.438587179539375 no 1890 0.430146722518703 677 698907 SGTC_2474 5321570 43.32 µM -0.178151597753809 0.437737812165371 no 1891 0.429301960475082 645 2841384 SGTC_1612 st002233 45.4 µM -0.179652704084866 0.437145228835393 no 1892 0.428712612938144 616 1035021 SGTC_2073 5212005 126 µM -0.180415177747359 0.436844285292117 no 1893 0.428413319856249 629 691789 SGTC_1763 st044482 94.5 µM -0.180819323214073 0.436684786434482 no 1894 0.428254697692777 621 88505 SGTC_822 1487-0950 154 µM -0.181880166887832 0.436266166032812 no 1895 0.427838384707594 638 1958375 SGTC_1872 amphotericin b 148 nM -0.18197569927031 0.436228471416646 no 1896 0.4278008983206 642 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.182050953731854 0.436198778353306 no 1897 0.427771369338281 682 6710655 SGTC_1449 4112-4002 201 µM -0.184769362030366 0.43512642160303 no 1898 0.426704969806422 624 2059539 SGTC_336 4111-0029 111 µM -0.184845168127417 0.435096524439879 no 1899 0.426675239607457 647 3131175 SGTC_1733 st037357 54.9 µM -0.18506299209366 0.43501061892127 no 1900 0.426589814103166 675 1272339 YGL099W LSG1 SGTC_1789 tunicamycin 25 nM -0.185698880049673 0.434759854692477 no 1901 0.426340453318337 649 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2007 4011539 71.82 µM -0.186306876141872 0.434520114238627 no 1902 0.426102057743943 601 45595301 SGTC_782 0083-0095 30.5 µM -0.186419297069762 0.434475787897401 no 1903 0.426057980396918 671 3591729 An indicator and reagent. SGTC_2512 diallyl trisulfide 49.23 µM -0.186952299209386 0.434265642208147 no 1904 0.4258490165825 625 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_772 k072-0172 35.3 µM -0.187425860498774 0.434078947724765 no 1905 0.425663374055757 621 5861980 SGTC_3111 9122088 49.47 µM -0.187474283854113 0.434059858366214 no 1906 0.425644392363531 651 16876704 SGTC_1728 st035614 33.7865 µM -0.18812208756107 0.433804497287512 no 1907 0.425390473419081 642 15945546 SGTC_1289 0976-0073 69.1 µM -0.188220438372647 0.43376573028759 no 1908 0.425351925656804 660 3391136 SGTC_1676 st018489 23.4 µM -0.188585347783737 0.433621899290787 no 1909 0.425208908761771 616 3696235 SGTC_23 0213-0011 39.996 µM -0.189417379126876 0.433293982583622 no 1910 0.424882852224533 647 627608 SGTC_2955 9076254 12.21 µM -0.18947385557198 0.433271725985362 no 1911 0.424860722088609 618 16459619 SGTC_3285 9112818 20.8695 µM -0.191444985093294 0.432495063751846 no 1912 0.424088489385209 630 17017947 YPR165W RHO1 SGTC_1337 1486-1011 40.3 µM -0.191465633698587 0.43248692918649 no 1913 0.424080401383639 625 X1337 SGTC_3301 9125354 19.7965 µM -0.192869797639488 0.431933822900303 no 1914 0.423530469448104 627 41905162 SGTC_3 0833-0587 95.581 µM -0.194559261710506 0.431268512546701 no 1915 0.422868998983979 633 5382644 SGTC_2523 spermine 47.74 µM -0.194789678549591 0.431177789543248 no 1916 0.422778801421565 616 1103 A DNA binding polyamine. SGTC_1104 tacrolimus 29.8 µM -0.195996299973226 0.430702760752259 no 1917 0.422306531013708 631 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2463 5473429 200 µM -0.196109110150487 0.430658354188098 no 1918 0.422262382922422 643 5399405 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.196264960491159 0.430597006749474 no 1919 0.422201392735475 628 3256 An antibiotic and ribosome inhibitor. SGTC_1864 st057645 30.4 µM -0.197876948121299 0.429962577862412 no 1920 0.421570670144676 624 688666 SGTC_415 dibenzyl ketone 100 µM -0.199494041162332 0.429326321289336 no 1921 0.420938152070187 657 7593 SGTC_1757 st041620 31.8375 µM -0.199632281868421 0.429271938009566 no 1922 0.420884089334129 645 5289815 SGTC_851 0394-0702 453 µM -0.199750177090653 0.429225559613334 no 1923 0.420837984423965 625 762646 SGTC_3086 9117350 49.47 µM -0.199958969914348 0.429143425719728 no 1924 0.420756335141951 615 2679265 SGTC_3153 9100258 49.47 µM -0.200165200425278 0.429062302787567 no 1925 0.420675691209034 667 25236848 SGTC_2322 7413319 38.22 µM -0.20145893040528 0.428553469033737 no 1926 0.420169869911713 635 1840400 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.202066423393308 0.428314578380078 no 1927 0.419932398321549 633 4330530 SGTC_1362 1611-0397 101 µM -0.202306483063107 0.428220184507577 no 1928 0.419838566007123 626 27816 SGTC_3343 9148379 18.9835 µM -0.202929878446001 0.427975078377241 no 1929 0.419594920251623 634 1955036 SGTC_1021 4476-0760 85.3 µM -0.203246955909443 0.427850420752882 no 1930 0.419471006581014 636 746768 SGTC_1469 k284-2957 126 µM -0.20354458770121 0.42773341466161 no 1931 0.41935469953207 637 23884841 SGTC_2145 5634607 200 µM -0.203566518381447 0.427724793444179 no 1932 0.419346129850156 655 308662 SGTC_995 3931-2021 34.6 µM -0.204023263847475 0.427545249089275 no 1933 0.41916765966662 656 730143 SGTC_425 3825-7017 13.1 µM -0.204144543577396 0.427497577154362 no 1934 0.419120273229961 649 3397440 SGTC_949 1165-0505 146 µM -0.2045849425804 0.427324476567002 no 1935 0.41894821032681 632 6244267 SGTC_2913 7966556 36.57 µM -0.204760492042502 0.427255480047824 no 1936 0.418879627864987 647 2976516 SGTC_2400 5203494 178.7 µM -0.20752903718815 0.426167649393528 no 1937 0.417798358928034 615 6777674 SGTC_1475 4092-1048 11.7 µM -0.20964937524245 0.425334894789843 no 1938 0.416970670016008 651 2881759 SGTC_378 3970-0959 8.33 µM -0.209824359270788 0.425266185310802 no 1939 0.416902380149244 673 6615653 SGTC_939 1165-0479 45.3 µM -0.209846941085363 0.425257318468486 no 1940 0.416893567475493 663 1377347 SGTC_1759 st043059 70 µM -0.209851586725928 0.425255494343311 no 1941 0.416891754494629 671 669426 SGTC_216 k038-0035 28.382 µM -0.210009209249562 0.425193604318973 no 1942 0.416830242686193 629 4444231 YPR107C YTH1 SGTC_75 0159-0059 199.013 µM -0.210084933892362 0.425163871914234 no 1943 0.416800692051558 617 5377270 SGTC_2450 5739737 12.93 µM -0.210089206025591 0.42516219452324 no 1944 0.416799024916755 622 2262825 SGTC_973 1325-0077 65.9 µM -0.211766020729295 0.424503922533165 no 1945 0.416144789409936 656 2835149 SGTC_968 1309-0633 340 µM -0.211881292734137 0.424458677581942 no 1946 0.416099822745249 661 3761976 SGTC_399 oxolinic acid 75 µM -0.212428827116908 0.424243780665421 no 1947 0.415886249075731 641 4628 A DNA gyrase inhibitor. SGTC_3184 9108758 49.47 µM -0.214925882005336 0.423264020210986 no 1948 0.414912552740019 630 902885 SGTC_2264 7948757 110.76 µM -0.215280192300058 0.423125039040634 no 1949 0.414774435916888 626 2971411 SGTC_1070 indatraline 8.81 µM -0.216397939842668 0.422686656006932 no 1950 0.414338785997979 674 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_795 0685-0265 78 µM -0.217046220585768 0.422432442708774 no 1951 0.41408616228828 638 302754 SGTC_1332 1480-0653 17.5 µM -0.217150782634301 0.422391443336423 no 1952 0.414045419605996 657 5749438 SGTC_912 3474-0017 2.18 µM -0.217467693285188 0.422267186010682 no 1953 0.413921940780721 673 3360550 SGTC_1059 3448-6867 171 µM -0.217950292925036 0.422077978643441 no 1954 0.413733920419444 642 3934407 SGTC_3048 9093155 49.47 µM -0.21850295773834 0.421861323709293 no 1955 0.413518627026075 621 25236002 SGTC_2898 9056270 58.44 µM -0.218943533471645 0.421688626725492 no 1956 0.413347017124583 634 19154699 SGTC_2245 6637752 200 µM -0.218963186207244 0.421680923592019 no 1957 0.413339362517308 638 681890 SGTC_2141 5621638 7.665 µM -0.219874813755688 0.421323632853265 no 1958 0.412984326017037 671 2856238 SGTC_1783 st039459 87.517 µM -0.222229807036339 0.420400949726492 no 1959 0.4120674957692 691 729761 SGTC_2411 st077133 39.94 µM -0.22346490830845 0.419917213202846 no 1960 0.411586845852411 699 1403142 YNL221C POP1 SGTC_1335 1486-0900 202 µM -0.224376284709773 0.419560343432526 no 1961 0.411232261167528 622 X1335 SGTC_865 0488-0499 301 µM -0.225511395768006 0.419115957895371 no 1962 0.410790730568777 668 9634651 SGTC_1329 1447-1697 50.6 µM -0.226645967040215 0.418671886768076 no 1963 0.410349522861718 639 2840515 SGTC_234 nsc-17383 10.7 µM -0.229011128305508 0.417746496565312 no 1964 0.409430133411077 658 408974 SGTC_600 1495-0418 41.6 µM -0.229021338439816 0.417742502743514 no 1965 0.409426165586274 652 5377768 SGTC_1200 1643-0193 18.4 µM -0.229437305907409 0.417579799081757 no 1966 0.409264521733865 672 5403974 SGTC_206 4546-0025 72.014 µM -0.230553232551551 0.41714337954763 no 1967 0.408830951883054 695 6620745 YIL048W NEO1 SGTC_2486 5283202 22.39 µM -0.230938763582181 0.416992628751085 no 1968 0.408681187798346 657 1377751 SGTC_1143 3454-2408 5.08 µM -0.23123800185503 0.416875628661034 no 1969 0.408564954344929 647 X1143 SGTC_2945 9067681 61.76 µM -0.23133770475434 0.416836647153279 no 1970 0.408526228423207 673 16456930 SGTC_2056 5235370 200 µM -0.232482313489383 0.416389190508275 no 1971 0.408081711364972 669 5511916 SGTC_1150 3909-7983 10.9 µM -0.233567704535214 0.415964983619405 no 1972 0.407660301165478 650 23965914 SGTC_1185 1319-0113 81.3 µM -0.234139156587864 0.415741680472693 no 1973 0.407438474049244 672 4672763 SGTC_2843 9000894 45.46 µM -0.23428600940993 0.415684300001457 no 1974 0.407381473290803 627 2242070 SGTC_705 1124-0212 310 µM -0.235801393091426 0.41509229244558 no 1975 0.406793393553336 641 9554485 SGTC_2914 7968218 45.32 µM -0.23580351828402 0.415091462341977 no 1976 0.406792568970358 681 2977111 SGTC_1842 st055362 61.2 µM -0.237274375361607 0.414517034346102 no 1977 0.406221970019074 636 676032 SGTC_2146 5545642 200 µM -0.239106203070391 0.413801888688106 no 1978 0.405511615957961 651 825326 SGTC_2138 5575593 77.673 µM -0.240634211659877 0.413205572541389 no 1979 0.404919316049923 675 762213 SGTC_1987 st072290 61.9 µM -0.240765540151621 0.41315432999205 no 1980 0.404868419506807 673 54697379 SGTC_3036 9090181 49.47 µM -0.240935203166893 0.41308813203567 no 1981 0.404802668747357 641 25236586 SGTC_1565 sinapyl alcohol 95.1 µM -0.242026661258636 0.412662333532096 no 1982 0.404379752281251 661 5280507 A phenol propionate derived from cinnamic acid. SGTC_1524 corynanthine 62.1 µM -0.242561994355336 0.412453527463957 no 1983 0.404172363054795 695 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_461 N-acetylfarnesylcysteine 136 µM -0.242588956757459 0.412443011464391 no 1984 0.40416191847235 661 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3073 9114972 49.47 µM -0.243765081161062 0.411984355308218 no 1985 0.403706382908786 643 41905075 SGTC_334 1502-1024 68.5 µM -0.244299036138982 0.411776167195709 no 1986 0.403499614957291 683 3296216 SGTC_888 0916-0002 6.97 µM -0.24517661440134 0.411434054936108 no 1987 0.40315984143855 655 2802138 YIL048W NEO1 SGTC_1039 k821-0043 94 µM -0.245263080359653 0.411400350967301 no 1988 0.403126368213377 678 15992768 SGTC_645 0845-0943 5.41 µM -0.246999552570575 0.41072362211412 no 1989 0.402454285172631 672 1885106 SGTC_1768 st044301 37.178 µM -0.247083514398434 0.410690907667671 no 1990 0.402421795932157 676 3931349 SGTC_522 1273-0010 11.6 µM -0.24872747546437 0.410050488744098 no 1991 0.40178579712569 628 5705015 SGTC_1506 4226-2149 212 µM -0.250160830785676 0.409492308722807 no 1992 0.401231487430527 679 991114 SGTC_1247 0448-0043 5.84 µM -0.250912366930735 0.409199717277349 no 1993 0.400940931393478 681 3089013 YGL099W LSG1 SGTC_621 3584-0052 32.1 µM -0.251385250236423 0.409015638128642 no 1994 0.400758135125475 685 2273927 SGTC_2823 7987624 58.44 µM -0.253077608740812 0.408357018887385 no 1995 0.400104120700475 708 2239440 SGTC_1767 st044992 70.3 µM -0.255426640129616 0.407443269925455 no 1996 0.39919679858806 664 9600693 SGTC_2792 7535235 81.82 µM -0.25569503205763 0.407338900186261 no 1997 0.399093165763016 648 1281891 SGTC_445 e6 berbamine 66 µM -0.256925708467387 0.406860410613874 no 1998 0.398618062047466 672 6610268 A calcium/calmodulin antagonist. SGTC_2126 5251174 33.877 µM -0.257821237304966 0.406512314451685 no 1999 0.398272436724377 674 790722 SGTC_10 0279-0212 42.575 µM -0.258354247818331 0.406305165870158 no 2000 0.398066761578323 663 39851 YBR002C RER2 SGTC_133 0724-0033 378.92 µM -0.259811632303411 0.405738903702099 no 2001 0.397504538864752 653 280309 SGTC_1141 3253-0389 52.6 µM -0.260437684663324 0.405495713499087 no 2002 0.39726308871266 678 5402031 SGTC_2870 9038528 12.99 µM -0.26085369034381 0.405334136149714 no 2003 0.397102669208019 678 6463316 SGTC_1429 4049-0205 9.46 µM -0.261475423057703 0.40509268413268 no 2004 0.396862950000696 659 22774478 SGTC_73 0327-0325 16.231 µM -0.262477006769225 0.404703791690213 no 2005 0.396476855022373 673 53298 SGTC_1666 st014829 29 µM -0.263788149110344 0.404194846881913 no 2006 0.395971583437941 667 3858230 SGTC_667 1498-1044 59 µM -0.265535565193042 0.403516806254652 no 2007 0.395298457897514 656 6739982 SGTC_1115 galangin 695.678 nM -0.265977017782202 0.40334555752902 no 2008 0.395128454421417 705 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3258 9138477 49.47 µM -0.266192166081743 0.403262103702522 no 2009 0.3950456080028 635 4970355 SGTC_1634 st006576 41 µM -0.266236518570363 0.40324490037307 no 2010 0.395028529931694 674 3915356 SGTC_61 0978-8327 98.565 µM -0.267120281164846 0.402902147887352 no 2011 0.394688276332222 699 6150059 YHR072W ERG7 SGTC_465 cgp-37157 41 µM -0.267640488642459 0.402700429013713 no 2012 0.394488031045517 658 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_196 k015-0023 18.111 µM -0.267745101365706 0.402659866862335 no 2013 0.394447765468665 656 5211998 SGTC_1578 josamycin 24.2 µM -0.269358283229245 0.402034510588894 no 2014 0.393826992651663 697 5282165 A P450 substrate. SGTC_2328 6201408 200 µM -0.272592941013788 0.400781339656524 no 2015 0.39258306938618 700 2890418 SGTC_2696 st077691 74.316 µM -0.272977783432416 0.400632311701167 no 2016 0.39243514673908 699 757133 SGTC_2689 tacrolimus 100 µM -0.274355032291737 0.400099098846467 no 2017 0.39190589830545 674 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3030 9087619 49.47 µM -0.27459175355294 0.400007469050253 no 2018 0.391814951300033 658 25236973 SGTC_3242 9133940 49.47 µM -0.275337457639947 0.399718858768665 no 2019 0.391528494559024 689 17248444 SGTC_1758 st042942 75.2445 µM -0.277038785809262 0.399060598047189 no 2020 0.390875162235993 658 669317 SGTC_920 mycophenolic acid 780.421 nM -0.277893898298599 0.398729854790869 no 2021 0.390546903974899 664 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2521 angolensin 13.4 µM -0.278755054665073 0.398396847347151 no 2022 0.390216404430943 657 821428 A flavenoid. SGTC_2009 4012297 12.05 µM -0.278932297051941 0.398328317242576 no 2023 0.390148391164499 691 45595307 SGTC_987 1497-1013 404 µM -0.279831175172972 0.39798081770321 no 2024 0.389803516240526 677 1676435 SGTC_1407 3909-7909 12.3 µM -0.280456654164784 0.397739059939851 no 2025 0.389563588238105 663 4411780 SGTC_3314 9135860 59.4275 µM -0.281090230625009 0.39749421240541 no 2026 0.389320597026659 654 25252478 SGTC_2254 7938975 95.19 µM -0.281582213838975 0.39730411185596 no 2027 0.389131939938175 703 2969277 SGTC_1234 0326-0494 15.5 µM -0.283459411032496 0.396578994053203 no 2028 0.388412345757006 709 1547813 SGTC_403 arphamenine a 50 µM -0.284100697580436 0.396331361716027 no 2029 0.388166606195728 699 5487158 An arginine aminopeptidase inhibitor. SGTC_871 0574-0004 149 µM -0.285158919252627 0.395922821662594 no 2030 0.38776119596473 679 9551173 SGTC_1244 0416-0015 52.5 µM -0.28522903308915 0.395895757348994 no 2031 0.387734339305082 681 96201 SGTC_1440 4100-1550 40 µM -0.286564743658298 0.395380261962165 no 2032 0.387222806573908 683 742806 SGTC_2727 riluzole 51.77 µM -0.288323571694056 0.394701750663439 no 2033 0.386549532658012 681 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2968 9090663 33.37 µM -0.289643036469934 0.394192944062955 no 2034 0.386044669617377 716 25236811 SGTC_760 0568-0725 82.9 µM -0.291807372933038 0.393358732754963 no 2035 0.38521695384474 696 3916171 SGTC_2715 st079500 56.4 µM -0.294199975807102 0.392437109128502 no 2036 0.384302549564754 675 28246688 SGTC_1705 st027868 56.3335 µM -0.294932456603291 0.392155079973701 no 2037 0.384022738685912 681 292948 SGTC_2518 prenyletin 46.28 µM -0.294991687174733 0.392132276732535 no 2038 0.384000114987191 655 3873459 A coumarin with calcium channel inhibitory activity. SGTC_361 000s-0510 1.45 µM -0.295015803531066 0.392122992256788 no 2039 0.383990903621174 675 660 SGTC_2751 anetholtrithion 17.25 µM -0.295232489886237 0.392039573653901 no 2040 0.383908142096616 692 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2361 9034121 116 µM -0.295455344999806 0.391953785415624 no 2041 0.383823029989437 685 6496917 SGTC_1798 st045719 60.953 µM -0.295665320183523 0.391872960121555 no 2042 0.383742842070969 654 3980186 SGTC_840 0245-0196 390 µM -0.295890932544635 0.391786120843034 no 2043 0.383656687982008 657 3827528 SGTC_691 1548-0686 185 µM -0.296014860991732 0.391738422483859 no 2044 0.38360936614936 653 46495133 SGTC_3287 9117173 37.0625 µM -0.296260387407628 0.391643927541125 no 2045 0.383515617499795 659 2789709 SGTC_1834 st055981 52.8 µM -0.296886479233208 0.39140299459102 no 2046 0.383276589524196 703 471719 YDL150W RPC53 SGTC_2765 myclobutanil 7.74 µM -0.298035903292174 0.390960781188329 no 2047 0.382837880615905 720 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2784 7567673 72.73 µM -0.300389674639113 0.390055664403327 no 2048 0.381939969341969 682 3471247 SGTC_1897 st060201 15 µM -0.300778085774744 0.389906362323955 no 2049 0.381791860039247 675 611878 SGTC_979 1426-2828 121 µM -0.301242378954782 0.38972791311703 no 2050 0.381614838027525 686 747872 SGTC_1355 1499-0035 1.68 µM -0.301966145021592 0.389449782925021 no 2051 0.381338935646956 685 1548538 SGTC_413 propylparaben 100 µM -0.30281568199112 0.389123393491024 no 2052 0.381015165847904 689 7175 A pharmaceutical preservative. SGTC_1363 1636-0063 10.4 µM -0.303262001850114 0.388951950131949 no 2053 0.380845100790066 679 6072185 SGTC_2173 5763948 167 µM -0.303287147802872 0.388942291544068 no 2054 0.380835519898123 667 2867177 SGTC_280 3448-3607 3.04 µM -0.30400918351663 0.388664986141599 no 2055 0.380560447330388 684 626179 SGTC_2436 5633522 8.09 µM -0.305020606270257 0.388276634017018 no 2056 0.38017522908182 703 5724242 SGTC_252 miconazole 1.30953 nM -0.306233095808616 0.387811226257846 no 2057 0.379713587626134 690 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2213 7173844 200 µM -0.307253384842253 0.38741971846 no 2058 0.379325257059713 671 892728 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.307801275884112 0.387209527583933 no 2059 0.379116775339519 670 5355888 SGTC_124 0136-0217 7.121 µM -0.308369043917143 0.386991746059345 no 2060 0.378900767183889 711 3976905 SGTC_2425 5628681 7.85 µM -0.309545943627088 0.386540430319553 no 2061 0.378453134522623 681 5714958 SGTC_2208 7283366 200 µM -0.309568281053553 0.38653186587841 no 2062 0.378444640079051 676 898663 SGTC_2357 9067248 200 µM -0.31115355149714 0.385924195281969 no 2063 0.377841946008908 699 9150235 SGTC_2524 avocatin b 10.57 µM -0.312353531700398 0.385464401260289 no 2064 0.377385930593057 697 6710748 SGTC_2991 9074669 71.4286 µM -0.312655067407309 0.385348887699437 no 2065 0.37727136810346 720 17333109 SGTC_2917 7979103 53.79 µM -0.313645418961956 0.384969571289057 no 2066 0.376895179779976 712 2980565 SGTC_3355 9151058 44.0485 µM -0.315870960848073 0.384117564363887 no 2067 0.376050227095506 672 17015728 SGTC_1162 k048-0130 20.1 µM -0.316676570824034 0.383809289462175 no 2068 0.375744514136401 705 6797406 SGTC_2148 5546263 113.568 µM -0.319749497506196 0.382634079203947 no 2069 0.374579117173375 682 792097 SGTC_2084 5306078 60.6385 µM -0.321028136912111 0.382145393809833 no 2070 0.37409453416915 708 679340 SGTC_658 3253-0951 102 µM -0.321730763944516 0.381876935430106 no 2071 0.373828334866402 691 1184878 SGTC_1428 4049-0204 61.7 µM -0.322673777894037 0.381516719764651 no 2072 0.373471156473447 704 X1428 SGTC_1976 st070609 63.5 µM -0.323004958077287 0.381390238762206 no 2073 0.373345743582507 664 682556 SGTC_474 dl-dihydrosphingosine 5 µM -0.323641433862225 0.381147197909298 no 2074 0.37310475757291 678 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3166 9102297 49.47 µM -0.323680893445708 0.38113213164985 no 2075 0.373089818798572 691 25237072 SGTC_747 3448-8087 38.7 µM -0.323833369427449 0.381073915731833 no 2076 0.373032095596246 720 5168703 SGTC_3039 9090270 49.47 µM -0.324378991124398 0.380865617320244 no 2077 0.372825561622525 660 17173750 SGTC_401 neomycin 50 µM -0.325963228066518 0.3802610094287 no 2078 0.372226088347992 694 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1134 3477-0009 42.5 µM -0.326513550219161 0.380051052947269 no 2079 0.372017919493445 700 3973534 SGTC_2728 chlorpromazine 9.18 µM -0.326661083630162 0.379994772656023 no 2080 0.37196211878901 713 2726 A thorazine and dopamine antagonist. SGTC_958 1222-0007 33 µM -0.327591562646477 0.37963987688017 no 2081 0.371610251127325 719 7312461 SGTC_2769 toremifene 3.73 µM -0.330212084630575 0.37864092422931 no 2082 0.370619858146885 683 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_93 0109-0045 59.227 µM -0.330636330233032 0.378479276278387 no 2083 0.370459600322569 695 88733 SGTC_3005 9076496 71.4286 µM -0.331676308061434 0.378083109286297 no 2084 0.370066846171672 701 21368410 SGTC_443 clozapine 122 µM -0.332324289594784 0.377836333323842 no 2085 0.369822200347247 710 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1865 st057639 52.2 µM -0.333912405706314 0.377231729410917 no 2086 0.369222829082428 672 688818 SGTC_158 k038-0087 26.446 µM -0.334706708334008 0.376929447101962 no 2087 0.36892317027007 662 X158 SGTC_2473 5854593 8.94 µM -0.33570341371001 0.376550244478742 no 2088 0.36854726565445 683 2872951 SGTC_2096 5468907 200 µM -0.335834836794218 0.376500252646312 no 2089 0.368497709186654 688 759785 SGTC_2387 9077560 195.08 µM -0.336460462558761 0.376262300201196 no 2090 0.368261830837308 668 5303272 SGTC_2834 9001755 58.44 µM -0.337119193038384 0.376011807429214 no 2091 0.368013524746145 717 2989575 SGTC_2879 9041815 71.43 µM -0.338015778020316 0.375670950631143 no 2092 0.367675648864142 692 4942971 SGTC_1379 2144-0755 36.5 µM -0.338700017705498 0.375410886889391 no 2093 0.367417863661781 706 5392327 SGTC_2383 9036125 200 µM -0.339781550087628 0.374999936840921 no 2094 0.367010521528044 698 79580 SGTC_1491 4138-0063 26.5 µM -0.341201038244808 0.374460789026586 no 2095 0.366476120864011 707 23883227 SGTC_3155 9099265 49.47 µM -0.342897901551531 0.373816611040168 no 2096 0.365837635244472 719 25236499 SGTC_97 0535-0701 19.132 µM -0.343404965021436 0.373624183488166 no 2097 0.36564691242116 679 2832013 YGL099W LSG1 SGTC_1176 0848-0131 83.3 µM -0.344431961001477 0.373234541219061 no 2098 0.36526072810091 710 6769040 SGTC_2600 tangeritin 87.95 µM -0.345141874691471 0.372965275698711 no 2099 0.36499385698279 713 68077 A bioactive flavone. SGTC_737 1950-0117 57.9 µM -0.345255677172591 0.372922116944904 no 2100 0.364951082373195 706 5393513 SGTC_1370 2001-0092 44.6 µM -0.345488282709709 0.372833907968062 no 2101 0.364863658831019 707 790957 SGTC_2999 9069765 71.4286 µM -0.345923451541137 0.372668900581209 no 2102 0.364700121831648 701 2097066 SGTC_2162 5663267 200 µM -0.346158872117535 0.372579643506517 no 2103 0.364611660739086 735 6456493 SGTC_1164 k060-0068 93.7 µM -0.347190071454179 0.372188756512823 no 2104 0.364224264655492 692 5963676 SGTC_805 3852-0218 479 µM -0.347382666695731 0.372115765832855 no 2105 0.364151926744603 702 6615355 SGTC_3164 9100705 49.47 µM -0.347685020783845 0.372001187481911 no 2106 0.364038373665496 710 17174235 SGTC_1062 mesoridazine 14.2 µM -0.348101977656188 0.371843198518258 no 2107 0.363881799576536 705 4078 A neuroleptic. SGTC_1556 plumbagin 1.48 µM -0.349404654743246 0.371349740790006 no 2108 0.363392769648247 700 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_208 k072-0098 12.366 µM -0.349527815011649 0.371303098260497 no 2109 0.363346546318481 721 5948901 SGTC_1986 st071812 45 µM -0.350590552472312 0.370900703189896 no 2110 0.362947772622632 708 11838594 SGTC_3121 9125696 49.47 µM -0.350662816362767 0.370873346299699 no 2111 0.362920662247667 705 1235365 SGTC_572 0960-0087 17.7 µM -0.3525149379999 0.370172413009261 no 2112 0.362226058827595 675 6796365 SGTC_3246 9135460 32.98 µM -0.352807459702262 0.370061747856223 no 2113 0.362116395461733 702 41446951 SGTC_608 k048-0125 159 µM -0.353155992970882 0.369929906769314 no 2114 0.361985748713728 722 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_119 0121-0043 24.815 µM -0.353826328082876 0.369676379381734 no 2115 0.361734520635526 719 1092378 SGTC_2868 9035608 32.47 µM -0.355807127543315 0.36892755275017 no 2116 0.360992505472116 675 6462614 SGTC_2773 thioridazine 9.09 µM -0.355949105270297 0.368873898182605 no 2117 0.360939340112871 709 5452 An antipsychotic. SGTC_2639 lactacystin 53 µM -0.356684103970579 0.36859617692001 no 2118 0.360664153511866 696 3870 A proteasome inhibitor. SGTC_1782 st039423 80.636 µM -0.356833814862927 0.368539616658732 no 2119 0.360608109963474 717 2068169 SGTC_292 k038-0015 474 µM -0.357148089725065 0.368420893960411 no 2120 0.360490472429225 729 46368540 SGTC_1529 apigenin 74 µM -0.358625934311565 0.367862781502633 no 2121 0.3599374714482 741 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_784 4579-0127 173 µM -0.358782530154267 0.367803658930776 no 2122 0.359878891331195 731 1948547 SGTC_2701 st077767 14.721 µM -0.359279723329453 0.367615965011344 no 2123 0.359692920764822 708 5721188 SGTC_2055 5235184 200 µM -0.360427266241633 0.36718288025343 no 2124 0.359263819693937 757 2836034 SGTC_3220 9131269 49.47 µM -0.36204131961089 0.366574019612879 no 2125 0.358660576646081 705 17722206 SGTC_797 k781-0471 270 µM -0.36234169937783 0.366460745970977 no 2126 0.358548350310823 672 23738129 SGTC_458 nppb 133 µM -0.363186872292388 0.366142092487425 no 2127 0.3582326467368 691 4549 A chloride channel blocker. SGTC_159 3970-0959 50 µM -0.363297442971338 0.366100411116292 no 2128 0.358191351631434 694 6615653 SGTC_722 3534-0461 190 µM -0.36403064694593 0.365824058247184 no 2129 0.357917562117077 693 658262 SGTC_2612 dictamnine 15.46 µM -0.364066110534138 0.365810693383517 no 2130 0.35790432132542 703 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_537 1334-0398 209 µM -0.364180242522537 0.365767682528276 no 2131 0.357861709824388 710 5846986 SGTC_1047 2043-3044 82 µM -0.364493770302041 0.365649537678281 no 2132 0.357744662456908 768 669592 SGTC_2582 agaric acid 100 µM -0.365803893614307 0.36515598952619 no 2133 0.357255707137797 699 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.365891644204255 0.365122940193851 no 2134 0.357222965822115 733 1273210 SGTC_2426 5582046 32.21 µM -0.366582146780148 0.364862912540326 no 2135 0.356965363651344 716 2251934 SGTC_1761 st044296 37 µM -0.366772189563012 0.364791357626637 no 2136 0.356894476824835 706 1826700 SGTC_1274 0865-0114 173 µM -0.367804776160219 0.364402650462275 no 2137 0.356509403717192 692 870624 SGTC_1497 4476-2978 41.3 µM -0.367907277962586 0.36436407225703 no 2138 0.356471186626319 711 1528379 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.368865793031152 0.364003386209501 no 2139 0.356113880683563 713 91467 include heat shock SGTC_2054 5233173 129 µM -0.369847283120751 0.363634179544671 no 2140 0.355748141223379 681 6889 SGTC_1269 0831-0796 3.05 µM -0.369938366331735 0.363599923230535 no 2141 0.35571420698078 729 927758 SGTC_3270 9137563 49.47 µM -0.371183318599936 0.363131807220238 no 2142 0.355250498439315 680 17015724 SGTC_734 2023-0417 80 µM -0.372510355357562 0.362633051562697 no 2143 0.354756451712099 727 3935732 SGTC_2462 5162487 171.77 µM -0.372967889110319 0.362461145303106 no 2144 0.354586171584352 726 2259986 SGTC_275 trichlorophene 5.69 µM -0.373419000042878 0.362291679394387 no 2145 0.354418310280619 707 62616 SGTC_3089 9117425 49.47 µM -0.374806721320532 0.361770532484511 no 2146 0.353902107593 740 9401657 SGTC_1022 4477-0945 21.3 µM -0.37519502110733 0.361624755647612 no 2147 0.353757716387283 704 4648966 SGTC_1839 st053978 48 µM -0.375360795115903 0.361562526316536 no 2148 0.353696078904123 706 3788398 SGTC_3202 9113761 49.47 µM -0.375555898464749 0.361489291836649 no 2149 0.353623541206598 734 4798415 SGTC_2825 7998094 58.44 µM -0.375765642437015 0.361410567475558 no 2150 0.353545566182993 718 2987815 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.378335168488204 0.360446610258 no 2151 0.352590811461198 726 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3018 9082602 49.47 µM -0.378529052984456 0.360373910411385 no 2152 0.352518807679887 720 17332089 SGTC_1884 5633444 25 µM -0.378623800902384 0.360338385120457 no 2153 0.352483622629752 701 5724239 SGTC_761 k216-0224 480 µM -0.378951942886889 0.360215359131203 no 2154 0.352361775438211 764 1340404 SGTC_33 0986-0033 35.816 µM -0.379011089857084 0.360193185469266 no 2155 0.352339814324331 697 2848082 SGTC_1739 st037196 92.5 µM -0.379239388827656 0.360107602670467 no 2156 0.352255052137291 718 612214 SGTC_2814 7977482 42.97 µM -0.379508437757674 0.360006752869464 no 2157 0.352155169842541 721 6456762 SGTC_2235 salicylic acid 500 µM -0.379936924089728 0.359846159966772 no 2158 0.351996118725181 711 338 A COX inhibitor and kinase inhibitor. SGTC_3173 9105693 49.47 µM -0.380394802369024 0.359674578564265 no 2159 0.351826186140007 757 17096658 SGTC_468 gf-109203x 121 µM -0.381102159071154 0.359409565347585 no 2160 0.351563722695312 707 2396 A protein kinase C inhibitor. SGTC_2290 7904846 200 µM -0.382468292972168 0.358897930846975 no 2161 0.351057021495457 697 2962154 SGTC_1714 st033236 13.627 µM -0.382798775394232 0.358774198957428 no 2162 0.350934484777419 725 2916566 SGTC_2040 5100729 123 µM -0.382997564725121 0.358699779807487 no 2163 0.35086078486681 711 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2437 5741531 144.16 µM -0.383079433516804 0.358669132811125 no 2164 0.350830434151529 710 2262990 SGTC_1450 4112-4260 37.6 µM -0.383576622782473 0.35848303311789 no 2165 0.350646134672252 707 1633175 SGTC_66 0109-0187 42.4 µM -0.383802461642797 0.358398511932747 no 2166 0.350562431709836 692 759417 SGTC_622 1348-1566 26.3 µM -0.385029061691011 0.357939572727531 no 2167 0.350107942075343 712 7340407 SGTC_2451 5856223 45.7 µM -0.38559744758981 0.357726977541241 no 2168 0.349897411921703 698 2179896 SGTC_708 3448-5400 146 µM -0.38678906822506 0.357281415188123 no 2169 0.349456185426495 727 3462195 SGTC_3115 9123671 49.47 µM -0.386969119198362 0.357214108704036 no 2170 0.349389534846754 719 3286988 SGTC_3324 9138759 60.749 µM -0.38697492653631 0.357211937884416 no 2171 0.349387385185926 721 45595710 SGTC_3280 9140961 49.47 µM -0.388866636380054 0.35650505111333 no 2172 0.348687401903793 721 4901226 SGTC_2028 5153890 36.43 µM -0.389227990018547 0.356370077860335 no 2173 0.348553749872234 726 2830968 YPR165W RHO1 SGTC_574 1315-0397 40 µM -0.391105929000574 0.355668917819487 no 2174 0.347859469146691 706 6794277 SGTC_787 4152-0075 138 µM -0.392500669566968 0.355148483715697 no 2175 0.347344158359682 689 9566539 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.392915649841 0.354993689885695 no 2176 0.347190891191164 696 6708739 YPR165W RHO1 SGTC_848 0368-0089 85.6 µM -0.395325454805942 0.354095270403713 no 2177 0.346301357971075 738 762535 SGTC_2848 9016370 25.97 µM -0.395619561775741 0.353985677404838 no 2178 0.346192851940218 697 7894410 SGTC_1724 st037281 8.293 µM -0.395714092683688 0.35395045494697 no 2179 0.346157978964427 688 574124 YDL195W SEC31 SGTC_2973 9094665 17.96 µM -0.396832568138568 0.353533803086839 no 2180 0.345745466268761 749 25237061 YIL048W NEO1 SGTC_2112 5488546 200 µM -0.398099514812364 0.353062054991445 no 2181 0.345278416009093 748 600757 SGTC_1270 0831-1170 17.3 µM -0.398834141419176 0.352788619833592 no 2182 0.345007709323563 733 6764716 SGTC_424 splitomicin 100 mM -0.398951859727573 0.352744810999579 no 2183 0.344964338011641 746 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3255 9139072 49.47 µM -0.400356227688064 0.352222326615813 no 2184 0.344447079717904 709 17646060 SGTC_2552 juarezic acid 87.02 µM -0.401147484740229 0.351928068196318 no 2185 0.344155771083087 713 1549512 SGTC_2489 cantharidin 73.42 µM -0.401260391563792 0.351886086811004 no 2186 0.344114210920652 733 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2223 6903751 107.57 µM -0.401304212025266 0.351869793829708 no 2187 0.344098081441692 723 5598863 SGTC_1436 4092-1007 8.32 µM -0.401354727387143 0.351851011940426 no 2188 0.344079488049098 702 2881121 SGTC_2607 solasodine 47.35 µM -0.401650918262699 0.351740893819953 no 2189 0.343970475467649 709 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3142 9086498 49.47 µM -0.401664397955943 0.351735882622824 no 2190 0.343965514596409 727 25236367 SGTC_1984 st072354 53.1 µM -0.401964668723097 0.351624260945608 no 2191 0.34385501425299 716 5762938 SGTC_1403 3909-7815 62.9 µM -0.40203753002292 0.351597177651385 no 2192 0.343828203134886 711 6615483 SGTC_1737 st035557 69.7 µM -0.402427803803217 0.351452121701125 no 2193 0.343684605613503 735 5716916 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.403225670026256 0.35115564017817 no 2194 0.343391108531343 727 756377 SGTC_1398 3558-0053 112 µM -0.404213326773453 0.350788759281472 no 2195 0.343027927313792 699 4532369 SGTC_1132 3456-3614 2.5 µM -0.405073890753003 0.350469202404713 no 2196 0.34271159882966 734 3125502 SGTC_1306 1185-0270 9.02 µM -0.405244187533725 0.350405977910886 no 2197 0.342649013729936 721 1548076 SGTC_2065 5221596 34.26 µM -0.406595693238772 0.349904364113277 no 2198 0.342152480459488 718 788581 SGTC_473 2-arachidonoylglycerol 10 µM -0.408631310839746 0.349149335343345 no 2199 0.34140512458206 697 5282280 An endocannabinoid. SGTC_3041 9091929 49.47 µM -0.410159255851726 0.348582998719073 no 2200 0.340844563553486 718 25236887 SGTC_1679 SEC14.276 6.7 µM -0.412289888085642 0.347793837883296 no 2201 0.340063479690209 706 1005053 YMR079W SEC14 SGTC_3105 9121040 49.47 µM -0.413001066516364 0.347530572365184 no 2202 0.339802916172858 705 41448907 SGTC_2246 7293507 91.5585 µM -0.413548173070375 0.347328093345894 no 2203 0.339602517833745 749 887656 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.413729763154388 0.347260898180199 no 2204 0.339536013658661 743 551469 SGTC_3353 9151644 39.2805 µM -0.414266650093574 0.347062257892788 no 2205 0.339339417487924 728 4909158 SGTC_2221 6807166 181.081 µM -0.414587083843462 0.346943722126357 no 2206 0.339222102538267 724 674925 SGTC_2448 5185112 27.17 µM -0.415157222369437 0.346732851893776 no 2207 0.339013405971538 693 5718189 SGTC_16 erodoxin 22.806 µM -0.415309173742863 0.346676659488761 no 2208 0.338957793208853 747 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2479 5617353 43.85 µM -0.415402241274185 0.346642244299129 no 2209 0.338923733107277 756 2731746 SGTC_2790 5423970 71.43 µM -0.415773091350464 0.34650512122825 no 2210 0.338788025478703 727 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2622 2-methoxyxanthone 59.94 µM -0.416468763270556 0.346247948441855 no 2211 0.338533510088347 722 71034 A hepatoprotective. SGTC_742 0kpi-0133 140 µM -0.417602606682359 0.345828946382671 no 2212 0.338118845309834 734 2728852 SGTC_3317 9138495 8.753 µM -0.420836103278053 0.344635073694302 no 2213 0.336937383181793 739 17020139 SGTC_2995 9067767 71.4286 µM -0.421779837445016 0.344286918734271 no 2214 0.336592861937005 741 11673567 SGTC_2630 antimycin a 100 µM -0.423851514076125 0.34352311511145 no 2215 0.335837053240478 749 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1053 3366-3204 134 µM -0.423979237952553 0.343476045634838 no 2216 0.335790477488513 716 3632071 YPR165W RHO1 SGTC_1193 1488-0126 41.5 µM -0.424014154187566 0.343463178542187 no 2217 0.335777745383272 698 1384710 SGTC_796 1234-0020 70.7 µM -0.424953096808137 0.34311723388841 no 2218 0.335435433372653 695 46495034 SGTC_3047 9092122 49.47 µM -0.425488734503591 0.342919942035813 no 2219 0.335240216123888 756 17173831 SGTC_892 0929-0076 29 µM -0.425555865401605 0.342895218678259 no 2220 0.335215752891589 693 5751038 SGTC_1502 4534-4282 27.7 µM -0.427689338672295 0.342109841652885 no 2221 0.33443865644967 753 3278949 SGTC_482 fipronil 114 µM -0.429106362889133 0.341588581793438 no 2222 0.333922910979473 709 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2946 9065502 71.43 µM -0.429256748618714 0.341533279313795 no 2223 0.333868194409613 718 16489101 SGTC_1181 1222-0449 220 µM -0.431089870889304 0.340859445194874 no 2224 0.333201512679845 743 658318 SGTC_1222 0366-0074 1.18 µM -0.432262515289097 0.340428660908879 no 2225 0.332775313881351 738 286520 SGTC_2323 6148992 148.28 µM -0.433966809962598 0.339802939988287 no 2226 0.332156271439279 728 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.434247357465128 0.339699981002766 no 2227 0.332054413402844 725 16623 A steroid. SGTC_1857 st056007 79.3 µM -0.436787806439471 0.338768199161857 no 2228 0.331132621429426 728 619834 SGTC_349 k015-0014 24 µM -0.436875671992109 0.338735989579805 no 2229 0.331100758019806 720 2196908 SGTC_914 3820-6779 408 µM -0.437685138773904 0.338439312335245 no 2230 0.330807271970763 710 2893481 SGTC_1968 st069590 43.6 µM -0.437807231376741 0.338394572936121 no 2231 0.330763014225007 747 6384066 SGTC_3162 9099653 49.47 µM -0.439200584429638 0.337884156791019 no 2232 0.330258100813414 720 25237511 SGTC_942 3253-1115 227 µM -0.439747346088742 0.337683947206498 no 2233 0.330060053539887 772 46497897 SGTC_1951 sophoraflavanone G 9.2 µM -0.440533089573421 0.337396309263724 no 2234 0.329775525978865 741 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1513 0337-0559 19 µM -0.441409645069721 0.337075539772089 no 2235 0.329458230456832 714 775073 SGTC_168 3970-0862 530.542 µM -0.442161612261586 0.336800456880278 no 2236 0.32918613121154 740 3135186 SGTC_1917 st066507 28.5 µM -0.445301081702272 0.335652927778959 no 2237 0.328051093132097 723 3156428 SGTC_3135 9127742 49.47 µM -0.44721584881757 0.334953798919759 no 2238 0.327359609611832 723 3643468 SGTC_3286 9117135 37.221 µM -0.447380822619701 0.334893589611811 no 2239 0.32730005997176 740 3438150 SGTC_1079 idarubicin 2.36 µM -0.449593941841227 0.334086294170457 no 2240 0.326501628574367 757 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1304 1165-0502 251 µM -0.450346788815471 0.333811847411976 no 2241 0.326230203327181 717 767425 SGTC_868 0527-0199 213 µM -0.45044413577448 0.333776366530631 no 2242 0.326195113371595 751 2849450 SGTC_2261 9010538 184.68 µM -0.450526491356484 0.333746350845623 no 2243 0.326165428450907 787 6457250 SGTC_1711 st032263 62.8 µM -0.450742843750862 0.333667503150131 no 2244 0.326087449869066 741 3958979 SGTC_631 k072-0230 41.5 µM -0.453493547766721 0.332665675069142 no 2245 0.325096694205825 740 5773147 SGTC_578 3460-0051 92 µM -0.455615195338382 0.331893769313165 no 2246 0.324333357136698 779 2876744 SGTC_847 0342-0274 5.54 µM -0.455963043310807 0.33176728190945 no 2247 0.32420827693744 736 18097 SGTC_2829 7992743 58.44 µM -0.456921873037743 0.331418723498016 no 2248 0.323863600855161 752 16462845 SGTC_2215 7188065 200 µM -0.457368469078973 0.33125642455655 no 2249 0.323703111906961 741 940217 SGTC_579 4491-1009 110 µM -0.458088841757009 0.330994698341474 no 2250 0.323444307555833 773 1271041 SGTC_2274 7947094 46.08 µM -0.459302268495319 0.330554022169869 no 2251 0.32300855948231 714 2971028 SGTC_373 0844-0104 25.9 µM -0.460259329140166 0.330206615221632 no 2252 0.32266504509185 740 5375804 SGTC_2866 9034245 58.44 µM -0.460514726587396 0.330113932289305 no 2253 0.32257340175172 727 6462273 SGTC_529 4076-0302 30.3 µM -0.460645010850814 0.33006665655385 no 2254 0.322526656472873 735 5816522 SGTC_618 k072-0232 33.2 µM -0.460659414765203 0.330061430028961 no 2255 0.322521488599632 761 5872756 YGL099W LSG1 SGTC_2556 citropten 84.59 µM -0.461075432639294 0.329910490395037 no 2256 0.322372243443667 709 2775 A potential DNA crosslinker. SGTC_710 3448-4187 58 µM -0.461075439018622 0.329910488080702 no 2257 0.322372241155322 722 3946412 SGTC_2763 lisinopril 49.32 µM -0.461713714381714 0.329678962805844 no 2258 0.322143317453195 774 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1936 st074407 74.3 µM -0.462674445121987 0.329330594499076 no 2259 0.321798869177671 724 809813 SGTC_674 0498-0004 451 µM -0.463261620593291 0.32911775308717 no 2260 0.321588426045659 732 4231473 SGTC_2789 5281112 71.43 µM -0.463484429275494 0.329037003110078 no 2261 0.321508586602227 749 765948 SGTC_4 0960-0234 25.671 µM -0.463582397063614 0.329001500300924 no 2262 0.321473484234461 725 6821112 SGTC_1008 4106-0037 6 µM -0.463622551449004 0.328986949091316 no 2263 0.321459097170033 779 2905394 SGTC_901 1112-0062 60.1 µM -0.464269637834792 0.328752492656346 no 2264 0.321227287124562 733 1908457 SGTC_2189 6047310 154.431 µM -0.464755591662658 0.328576463086628 no 2265 0.321053246440306 743 711535 SGTC_1288 0973-0013 65.5 µM -0.464840428211621 0.328545736203139 no 2266 0.321022866901281 739 4315430 SGTC_2531 methyl deoxycholate 70.07 µM -0.46535416549228 0.328359690872279 no 2267 0.320838925779134 769 16667744 Haematoxylin. SGTC_2081 5214970 32.255 µM -0.465715254920302 0.328228951050921 no 2268 0.32070966578557 738 2063512 SGTC_2178 5812956 200 µM -0.465820620770461 0.328190805151526 no 2269 0.32067195183145 738 5403383 SGTC_792 4534-1957 155 µM -0.468300954381241 0.327293361104732 no 2270 0.319784693015873 729 1717904 SGTC_1340 1486-1359 257 µM -0.468727308947984 0.327139196136996 no 2271 0.319632282135918 741 4309068 SGTC_1807 st050092 58.9 µM -0.470752566420863 0.326407289140371 no 2272 0.318908720562318 759 5008496 SGTC_2697 mebhydrolin 72.4 µM -0.471223528898702 0.326237183806498 no 2273 0.318740559030724 733 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_103 0844-0104 51.839 µM -0.471403466782952 0.326172202194936 no 2274 0.318676320386603 755 5375804 SGTC_676 falcarinol 140 µM -0.471503072387412 0.326136233535892 no 2275 0.318640763074986 788 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2088 5278280 127.392 µM -0.473207282913435 0.325521075523223 no 2276 0.318032651173366 754 791502 SGTC_2403 6032726 181.2 µM -0.475597577113101 0.324659066730675 no 2277 0.317180550924451 740 2881040 SGTC_1061 3448-9325 110 µM -0.476385457576384 0.324375139776254 no 2278 0.316899896567292 778 723482 SGTC_297 0986-0032 24 µM -0.476494644714684 0.324335800268385 no 2279 0.3168610108437 762 2847425 SGTC_1408 3909-7976 48.8 µM -0.47686368948946 0.324202850039572 no 2280 0.316729594835614 734 24152374 SGTC_813 k007-0158 173 µM -0.477766669852294 0.323877641378726 no 2281 0.316408143117074 762 6523916 SGTC_1741 st038134 10.228 µM -0.478072751230771 0.323767436561376 no 2282 0.316299212749526 767 1272587 SGTC_2853 9015042 58.44 µM -0.478324780824821 0.323676704724978 no 2283 0.316209530671312 730 6457456 SGTC_2384 9036245 200 µM -0.480117943684369 0.323031460471318 no 2284 0.315571764886943 752 6462766 SGTC_682 0kpi-0099 17 µM -0.481613774857872 0.322493613833959 no 2285 0.315040169468673 758 1714895 YML126C ERG13 SGTC_2330 7979373 200 µM -0.481726193041547 0.322453207319185 no 2286 0.315000233228746 735 1863007 SGTC_539 4859-0462 2.54 µM -0.483582998993658 0.321786118474638 no 2287 0.314340921347073 733 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_121 0557-0495 61.343 µM -0.487684599288934 0.320314586249914 no 2288 0.312886630994882 769 3104427 SGTC_1019 4262-0212 3.4 µM -0.48812052726925 0.320158353705109 no 2289 0.312732236026003 763 4677213 SGTC_1197 1601-0112 267 µM -0.489381778773073 0.319706512494487 no 2290 0.312285716855009 751 7350313 SGTC_2745 rifampicin 24.3 µM -0.489396670491669 0.319701179157851 no 2291 0.312280446404631 740 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_347 4534-1311 26.2 µM -0.490759001509821 0.319213430243547 no 2292 0.311798455250798 751 2862016 SGTC_1038 k292-0204 154 µM -0.491471410490519 0.318958494313899 no 2293 0.311546534001582 770 4454212 SGTC_577 r071-0003 38.6 µM -0.492233486290214 0.318685879868665 no 2294 0.311277147257248 756 4568517 YMR134W ERG29 SGTC_1731 st035964 63 µM -0.492343028989537 0.318646701640848 no 2295 0.311238433228918 773 6739575 SGTC_39 0986-0283 58.349 µM -0.492716569557153 0.318513119142133 no 2296 0.311106434106495 734 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2303 7774051 200 µM -0.493385311665818 0.318274028024481 no 2297 0.310870179435949 799 2953184 SGTC_856 0433-0016 11.3 µM -0.493663353387628 0.318174643803812 no 2298 0.310771975184143 757 3911780 SGTC_2424 5537928 59.2 µM -0.496137340699534 0.317290910048928 no 2299 0.309898757809762 766 5382802 SGTC_2985 9022375 71.43 µM -0.497772343271799 0.316707441057236 no 2300 0.30932225570997 783 4939335 SGTC_2423 st077119 87.2 µM -0.499246071165869 0.316181915155369 no 2301 0.308803020937714 740 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_145 3737-0113 38.366 µM -0.500715541912106 0.315658276805632 no 2302 0.308285666309387 751 6849351 SGTC_457 grayanotoxin iii 135 µM -0.502519562660431 0.315015929056355 no 2303 0.307651047522647 775 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_233 rapamycin 362 pM -0.503148223512724 0.314792216496797 no 2304 0.307430032114719 769 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_438 sphingosine 6.67 µM -0.50324112070362 0.314759164260745 no 2305 0.307397378602069 748 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_886 0866-0150 153 µM -0.503253159031264 0.314754881208115 no 2306 0.307393147222178 756 271463 SGTC_485 niflumic acid 177 µM -0.503835433632535 0.314547746583672 no 2307 0.307188512778246 758 4488 A COX2 inhibitor. SGTC_431 k089-0097 107 µM -0.503940177398416 0.314510491900839 no 2308 0.30715170802324 772 5499420 SGTC_739 1486-1183 203 µM -0.50406193469259 0.314467188314189 no 2309 0.307108927514083 754 4346692 SGTC_1781 st038725 66.3 µM -0.507392723279629 0.313283568485321 no 2310 0.305939645209152 739 4270275 YIL048W NEO1 SGTC_1103 duloxetine 36.1 µM -0.508635324249393 0.312842492518114 no 2311 0.305503931972459 762 60835 A selective serotonin reuptake inhibitor. SGTC_1848 st056003 16.4 µM -0.509267866688666 0.312618066886937 no 2312 0.305282239113174 747 146492 SGTC_1887 st057648 70.8 µM -0.510785942551208 0.312079738103709 no 2313 0.304750476801965 776 688672 SGTC_1982 st072467 71.9 µM -0.510981895256314 0.31201028001315 no 2314 0.304681867123797 776 3163533 SGTC_472 calcifediol 10 µM -0.513505091146355 0.311116496881071 no 2315 0.303799025202229 748 5283731 A vitamin D metabolite. SGTC_2091 4-phenylthiadiazole 200 µM -0.514051331383564 0.310923150393328 no 2316 0.303608051390682 767 270010 SGTC_1882 5615643 20 µM -0.515129541192534 0.310541661843809 no 2317 0.303231250414604 756 2253075 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.516136972608992 0.310185399895463 no 2318 0.302879373364027 772 88881 An O-methylated flavonoid and antioxidant. SGTC_687 k029-0044 34.9 µM -0.516223639189453 0.310154759964746 no 2319 0.302849110881038 775 5829338 SGTC_877 0771-0151 33.1 µM -0.51665244484641 0.310003180260668 no 2320 0.302699399226989 763 6166523 SGTC_511 blebbistatin 171 µM -0.519922133527911 0.308848432117599 no 2321 0.301558923978838 772 3476986 A myosin inhibitor. SGTC_755 1995-0008 37.3 µM -0.519935512291111 0.308843711040713 no 2322 0.301554261407476 753 689533 SGTC_2052 5265182 7.135 µM -0.520985881583352 0.308473157013118 no 2323 0.301188303304918 771 1239884 SGTC_248 streptozotocin 5.23457 mM -0.522705315042979 0.307866988506866 no 2324 0.300589669483596 800 5300 DNA alkylating agent. SGTC_273 hydroxyurea 18.1 mM -0.524290587261978 0.307308581281609 no 2325 0.300038221367256 792 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_95 0471-0001 561.058 µM -0.524452801433014 0.307251466998924 no 2326 0.299981819845782 753 4015405 SGTC_1777 st045864 34.765 µM -0.524603412969435 0.307198442094138 no 2327 0.299929456831177 783 4691462 SGTC_3054 9094397 49.47 µM -0.524665448520718 0.307176602779835 no 2328 0.299907890174444 783 2598354 SGTC_2643 anethole 100 µM -0.524808167115331 0.307126361988993 no 2329 0.299858276726293 793 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_681 1642-0006 26.6 µM -0.525466054611165 0.306894814687283 no 2330 0.299629622507945 785 4446530 SGTC_1048 3161-0300 24.5 µM -0.525774036762639 0.306786445050417 no 2331 0.299522607928759 744 2165101 SGTC_3229 9132204 49.47 µM -0.526172928797801 0.306646112062362 no 2332 0.299384030641406 773 17682924 SGTC_285 1486-1325 46 µM -0.527025997238324 0.306346091793975 no 2333 0.299087767595881 760 22310230 SGTC_24 0417-1663 219 µM -0.527640862909778 0.306129926821378 no 2334 0.298874312816141 790 4329390 SGTC_662 k832-1615 104 µM -0.5290467459661 0.305635921824645 no 2335 0.29838651124153 771 5878478 SGTC_1314 1222-0010 41.1 µM -0.529136042331844 0.305604556431503 no 2336 0.29835554017581 779 3526027 SGTC_1360 1598-0022 39.8 µM -0.531616745966414 0.30473377894308 no 2337 0.297495732058186 791 761525 SGTC_1156 4092-0367 4.88 µM -0.531915240724179 0.304629075595304 no 2338 0.297392350530293 791 1357585 SGTC_642 0335-0876 158 µM -0.535033894013074 0.303536100368198 no 2339 0.296313210030975 779 6812350 SGTC_1183 1254-0324 198 µM -0.538671926901993 0.302263319381503 no 2340 0.295056623840953 762 5799357 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.538770995139446 0.302228693461044 no 2341 0.295022439764319 767 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1060 3448-7350 82 µM -0.539590734789833 0.301942249780928 no 2342 0.294739653818944 784 570178 SGTC_937 3122-0005 46.7 µM -0.539676913110744 0.301912143360426 no 2343 0.294709932108115 787 759535 SGTC_2839 9003951 25.97 µM -0.541088849129212 0.301419075318258 no 2344 0.294223171867295 776 2990634 SGTC_54 0159-0055 9 µM -0.541277807653159 0.301353115835728 no 2345 0.294158057233773 809 3319099 SGTC_2620 irigenin 100 µM -0.541340943738542 0.301331078460925 no 2346 0.294136302181287 780 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_466 geldanamycin 89.2 µM -0.541719656462423 0.301198905672108 no 2347 0.294005823237586 759 5288382 HSP90 inhibitor. SGTC_2378 9074213 121.43 µM -0.543804641385613 0.300471702831995 no 2348 0.293287957277148 767 657714 SGTC_2262 9014885 67.46 µM -0.5439208583857 0.300431191910077 no 2349 0.293247967363841 761 6457424 SGTC_566 0958-0068 16.5 µM -0.546047293624549 0.299690395152103 no 2350 0.292516714165242 790 6815365 SGTC_764 1951-2361 146 µM -0.549307251057953 0.298556317276781 no 2351 0.291397306027095 764 5438930 SGTC_956 1185-0240 191 µM -0.549693619514557 0.298422036442465 no 2352 0.291264766944724 771 1416193 SGTC_2325 6158266 200 µM -0.550466062411868 0.298153659393529 no 2353 0.290999874037549 755 3623240 SGTC_3138 9097216 49.47 µM -0.551761547486103 0.297703803911423 no 2354 0.290555867767617 794 25237486 SGTC_398 bronopol 33.3 µM -0.552956863830604 0.297289006793537 no 2355 0.290146474089144 772 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_202 3594-0513 34.79 µM -0.553745016598856 0.297015647605313 no 2356 0.289876681154317 780 708429 SGTC_3223 9129970 49.47 µM -0.55401840262225 0.296920854549647 no 2357 0.289783125752647 770 17248386 SGTC_1648 st011736 69.8 µM -0.554391811705502 0.296791402166484 no 2358 0.289655364364519 780 2855514 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.556450892876136 0.296078030335963 no 2359 0.288951327982411 798 2346 DNA damaging agent; causes G2/M arrest. SGTC_2506 ethyl hematommate 54.16 µM -0.55728562624197 0.295789060017028 no 2360 0.28866614738092 774 3940691 An allergen. SGTC_1471 k673-0312 37 µM -0.557546986618577 0.295698608197365 no 2361 0.288576882762083 776 24099884 SGTC_775 4577-0580 57.3 µM -0.56140943039404 0.294363374971681 no 2362 0.287259228353844 793 2006902 SGTC_507 nimesulide 162 µM -0.561547064423742 0.294315846782138 no 2363 0.287212327740226 783 4495 A COX2 inhibitor. SGTC_1670 st016595 4.04 µM -0.562173029098881 0.294099731537272 no 2364 0.286999067748548 806 597879 SGTC_2752 diclazuril 33.15 µM -0.562498434231307 0.293987413907452 no 2365 0.286888235066677 779 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1036 k216-0215 33.5 µM -0.564504016916383 0.293295600302243 no 2366 0.286205583587243 768 622330 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.566782322129582 0.29251062939519 no 2367 0.285431041236236 799 688788 SGTC_1082 camptothecin 424.86 nM -0.567234053050249 0.29235510537016 no 2368 0.28527758751781 804 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1850 st056238 17 µM -0.567383225564929 0.292303756008825 no 2369 0.285226922009334 794 5393177 SGTC_2140 5586273 200 µM -0.568657266091525 0.291865366543845 no 2370 0.284794376922787 786 854421 SGTC_2252 omeprazole 400 µM -0.569104261383182 0.291711630836358 no 2371 0.284642693309373 769 4594 A proton pump inhibitor. SGTC_894 0960-0238 55.9 µM -0.569157042225644 0.291693480339926 no 2372 0.284624785177396 802 6741907 YDL195W SEC31 SGTC_2277 7947813 106.88 µM -0.570899689886782 0.291094507195733 no 2373 0.284033820592053 794 1246798 SGTC_1344 1488-0097 29.1 µM -0.571073363600856 0.291034844526233 no 2374 0.283974956751393 812 747966 SGTC_2279 7948423 32.93 µM -0.571134027624263 0.291014005772444 no 2375 0.283954397056958 747 1247112 SGTC_1573 oleylamine 1.06 µM -0.571353415371836 0.290938649507574 no 2376 0.28388005012019 802 5356789 An amine of the fatty acid oleic acid. SGTC_2674 ligustilide 100 µM -0.572255157037191 0.290629011135957 no 2377 0.283574562440294 760 5319022 A signalling regulator. SGTC_2636 apigenin dimethyl ether 100 µM -0.573363970925076 0.290248480157462 no 2378 0.283199139891803 808 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1125 tnp00248 1.32998 µM -0.57360428047338 0.290166039725673 no 2379 0.283117807259216 773 24207736 SGTC_2709 st078560 56 µM -0.574378050393535 0.289900665305478 no 2380 0.282856001437711 809 17250903 SGTC_176 1486-1328 72.834 µM -0.574639964566647 0.289810864238009 no 2381 0.282767408864385 770 22310231 SGTC_348 k064-0012 10.7 µM -0.57524387458506 0.28960385469245 no 2382 0.282563186879816 787 5066323 SGTC_596 1155-0152 116 µM -0.575833370331517 0.289401853078685 no 2383 0.28236390772922 792 280313 SGTC_3218 9131285 49.47 µM -0.579805157667408 0.288042575213552 no 2384 0.281023009537203 810 17156417 SGTC_1594 piperine 70.1 µM -0.582500586312953 0.28712182953455 no 2385 0.280114773353627 787 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1190 1486-1332 13 µM -0.582734774783512 0.287041897701519 no 2386 0.280035929764506 794 4150046 SGTC_2391 6285546 200 µM -0.583616499793134 0.286741047071968 no 2387 0.2797391783618 790 846083 SGTC_2862 9027634 71.43 µM -0.584571969576079 0.286415203081094 no 2388 0.279417779939941 783 5012562 SGTC_2890 9046729 58.44 µM -0.584693327542561 0.286373828938262 no 2389 0.279376970705982 790 903329 SGTC_1523 st012844 44.7 µM -0.586336909487262 0.285813767928882 no 2390 0.278824566150862 788 4274103 SGTC_1875 nocodazole 6 µM -0.586949703972955 0.285605087697126 no 2391 0.278618743291734 792 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3008 9078912 71.4286 µM -0.587268742927011 0.285496471299074 no 2392 0.278511615112717 793 16648731 SGTC_487 nimodipine 119 µM -0.587558234037931 0.285397931446493 no 2393 0.278414425994483 782 4497 L-type voltage-gated calcium channels inhibitor SGTC_946 3434-1334 87.4 µM -0.58899652095224 0.284908593392152 no 2394 0.27793180371602 778 4047976 SGTC_1766 st045414 44.774 µM -0.591525059114062 0.284049298507152 no 2395 0.277084334931487 812 253960 SGTC_2671 danthron 100 µM -0.592008814628734 0.283885041103621 no 2396 0.276922342915371 791 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_565 1418-0001 44.5 µM -0.592148296285226 0.283837689066323 no 2397 0.276875644228014 808 2862145 SGTC_1037 k284-1091 78.7 µM -0.592473610356257 0.283727264264466 no 2398 0.276766743532208 797 3334711 SGTC_636 0kpi-0074 126 µM -0.593468246935961 0.283389771901963 no 2399 0.276433913614166 796 616434 SGTC_19 0279-0214 38.434 µM -0.593788253203439 0.283281230796272 no 2400 0.276326873378733 789 3566274 YBR002C RER2 SGTC_1899 st063254 59.6 µM -0.594169580988253 0.283151916434933 no 2401 0.276199348009555 794 3093813 SGTC_2803 7707263 71.43 µM -0.594281954394648 0.283113814216232 no 2402 0.276161773095569 786 2199229 SGTC_2936 9038235 15.59 µM -0.594850180139208 0.282921184771919 no 2403 0.2759718107576 786 4749415 SGTC_2812 7970281 58.44 µM -0.595262989814778 0.282781281105392 no 2404 0.275833845493325 802 2233435 SGTC_294 k038-0071 157 µM -0.595967713830408 0.282542522749287 no 2405 0.275598397774338 794 24152826 SGTC_839 0122-0028 230 µM -0.597899799790988 0.281888435451403 no 2406 0.274953396741234 812 759448 SGTC_433 pimozide 108 µM -0.598923426940045 0.281542193198565 no 2407 0.274611974199231 789 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1627 st003713 25.6 µM -0.600413216652441 0.281038638138456 no 2408 0.274115440866893 778 16195070 YER133W GLC7 SGTC_2069 5228469 200 µM -0.600580655664518 0.280982070275981 no 2409 0.274059662708906 815 2835210 SGTC_1152 3909-8331 15.9 µM -0.6019628188941 0.280515328343923 no 2410 0.273599443612129 803 16001939 SGTC_3098 9119039 49.47 µM -0.60239606464431 0.280369103110785 no 2411 0.273455264473999 798 17161528 SGTC_1940 st075990 51.1 µM -0.603092846311153 0.280134009032706 no 2412 0.273223462573603 814 1084979 SGTC_2072 5231554 129 µM -0.603818647865028 0.279889225270215 no 2413 0.272982110037707 806 789545 SGTC_515 4092-1064 102 µM -0.604756196085025 0.279573181472418 no 2414 0.272670501413573 840 717353 SGTC_131 0141-0277 33.849 µM -0.605497690238927 0.279323349482622 no 2415 0.272424179463355 815 1547771 SGTC_449 xestospongin c 11.1929 µM -0.608233798530494 0.278402410920794 no 2416 0.271516210576804 816 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1127 asiatic acid 681.4 nM -0.609530950348307 0.277966324075847 no 2417 0.271086282135077 806 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1900 st060200 72.8 µM -0.609680150396213 0.277916186197825 no 2418 0.271036853000875 785 688945 SGTC_2010 4012422 159 µM -0.613737136233866 0.276554552243373 no 2419 0.269694522076173 797 952393 SGTC_2166 5933061 31.504 µM -0.61464323370794 0.276250888852041 no 2420 0.269395178037969 795 2877375 SGTC_2150 5556613 200 µM -0.617634239192294 0.275249666431045 no 2421 0.268408234673282 815 743190 SGTC_1531 st059297 52.4 µM -0.618122047184088 0.275086545005052 no 2422 0.268247445081047 800 7566702 SGTC_337 1315-0038 354 µM -0.61962736087751 0.274583473297312 no 2423 0.267751574459756 810 1626437 SGTC_2289 7946404 165.07 µM -0.620364968431899 0.274337132659397 no 2424 0.26750876530952 796 1246120 YPR165W RHO1 SGTC_2900 5328528 85.29 µM -0.622097522164577 0.273758936828388 no 2425 0.266938872092315 804 795359 SGTC_5 0352-0601 109.883 µM -0.623075650695452 0.273432777653652 no 2426 0.266617404898602 799 762456 SGTC_754 3474-0146 171 µM -0.625143985682096 0.272743720830593 no 2427 0.265938280693966 805 24762078 SGTC_203 k066-0004 30.888 µM -0.625186866581024 0.272729444366483 no 2428 0.265924210311666 809 6795412 SGTC_1665 st014639 11.4 µM -0.626846659182949 0.272177129834666 no 2429 0.265379877504196 812 981133 YIL048W NEO1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.626974087628618 0.272134749586509 no 2430 0.265338110437334 797 94937 An inhibitor of serotonin biosynthesis. SGTC_2818 7996756 12.99 µM -0.628207239675349 0.271724796506428 no 2431 0.264934094139685 834 2241621 SGTC_1108 betulinic acid 729.144 nM -0.629331318958227 0.271351371934307 no 2432 0.264566085801513 792 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1534 6-azauridine 81.6 µM -0.630441081789658 0.270982954397624 no 2433 0.264203019767636 805 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2505 galangin 7.89 µM -0.630720956555855 0.270890081376962 no 2434 0.264111497025119 806 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2331 7980721 200 µM -0.630742498772682 0.270882933514014 no 2435 0.264104453105398 803 2981221 SGTC_1677 st019204 53.9 µM -0.631820969344181 0.270525209552546 no 2436 0.263751934887564 793 3945625 SGTC_2093 5331342 194.4 µM -0.632442021586594 0.270319316389583 no 2437 0.263549041319149 803 33839 SGTC_786 4544-0069 423 µM -0.633610138158044 0.269932271126813 no 2438 0.26316764143609 802 748821 YLR208W SEC13 SGTC_2186 6124449 200 µM -0.634038615931689 0.26979036830908 no 2439 0.263027810560856 805 3834182 YLR033W RSC58 SGTC_2916 7875993 68.79 µM -0.635633712519432 0.269262434482333 no 2440 0.262507595400575 839 1299250 SGTC_1111 tnp00062 510.699 nM -0.636076963355859 0.269115822495039 no 2441 0.262363129819127 801 676306 SGTC_1773 st048542 73.5835 µM -0.636198928370575 0.269075487731265 no 2442 0.262323385776362 823 3237138 SGTC_777 1315-0167 517 µM -0.636456742661358 0.268990236557841 no 2443 0.262239383455263 811 4221767 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.636617098874945 0.268937218581647 no 2444 0.262187142356593 804 15053 SGTC_1365 1672-3266 55.4 µM -0.636686850246441 0.268914158583571 no 2445 0.262164420309701 811 6415873 SGTC_2200 6600604 21.907 µM -0.637153807032075 0.268759806941342 no 2446 0.262012331530178 841 2904777 SGTC_1226 3909-7979 35.4 µM -0.637218231076371 0.268738515194935 no 2447 0.261991352038426 814 6615510 SGTC_194 1486-1323 56.904 µM -0.63723730269783 0.268732212305083 no 2448 0.261985141588806 813 5178754 SGTC_2456 5770359 74.46 µM -0.638634084991947 0.26827079832487 no 2449 0.261530501108783 832 3118787 SGTC_3339 9145883 14.936 µM -0.639366373779572 0.268029052917577 no 2450 0.261292309420663 806 2030670 SGTC_1002 4049-0206 172 µM -0.639732639498247 0.267908181320686 no 2451 0.261173215937791 821 4662749 SGTC_2811 7967822 32.47 µM -0.639931447299393 0.267842584120782 no 2452 0.261108584077758 800 2232244 SGTC_1934 st074720 32.6 µM -0.63999251492675 0.26782243630773 no 2453 0.261088732813547 811 17250992 SGTC_1159 4092-0538 61.2 µM -0.640528639407058 0.267645587551211 no 2454 0.260914488044412 822 717301 SGTC_276 colchicine 750 µM -0.641767636907952 0.267237110834932 no 2455 0.260512032828366 826 2833 A microtubule depolymerizer. SGTC_1149 3909-7961 23.3 µM -0.641835092542775 0.26721488087637 no 2456 0.260490130847336 796 735261 SGTC_520 3584-0023 682 µM -0.642661097589248 0.266942747181579 no 2457 0.260222014498079 794 1340790 SGTC_2035 5154463 94.595 µM -0.644921290192037 0.266198825699552 no 2458 0.259489097028706 829 2769623 SGTC_2445 5742597 35.57 µM -0.644979201952536 0.266179778379206 no 2459 0.259470331876604 820 1774255 SGTC_954 1189-0853 2.85 µM -0.645240970279284 0.266093690742608 no 2460 0.259385519810889 827 2828194 SGTC_614 0462-0418 107 µM -0.646030325923524 0.265834181085671 no 2461 0.25912985794653 796 5188303 SGTC_750 4073-0104 132 µM -0.647276379776468 0.26542478791321 no 2462 0.258726542876148 797 22330957 SGTC_857 0438-0306 1.35 µM -0.647515743836071 0.26534618108065 no 2463 0.258649104204473 806 4686136 SGTC_2572 astragaloside iv 100 µM -0.647520276901192 0.265344692542224 no 2464 0.258647637790395 812 45006101 An anti-inflammatory agent. SGTC_1392 3455-1037 33.9 µM -0.647624149527095 0.265310584686574 no 2465 0.258614036919758 801 981132 SGTC_88 0180-0332 8.668 µM -0.648297207124354 0.265089631881424 no 2466 0.25839637003461 802 3101745 SGTC_2565 isoliquiritigenin 100 µM -0.648704404901 0.264956001508571 no 2467 0.258264728336952 799 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_439 amiodarone 34.4 µM -0.648827261970795 0.264915690142962 no 2468 0.258225017085532 826 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1049 3226-0134 66 µM -0.651529220013156 0.264029923373072 no 2469 0.257352460585292 810 5702385 SGTC_2098 5376439 882.5 nM -0.653091330851316 0.263518515254069 no 2470 0.256848700392101 802 2844116 SGTC_563 tetrahydrosecaminediol 614 µM -0.653341958129526 0.263436511296043 no 2471 0.256767924192632 828 334274 A psychoactive constituent of the cannabis plant. SGTC_964 1287-0107 19.4 µM -0.655064975223134 0.262873101788581 no 2472 0.256212960626241 801 51516812 YPR165W RHO1 SGTC_2137 5261020 140 µM -0.655302809923669 0.262795380620671 no 2473 0.256136406012157 814 763655 SGTC_214 4373-3496 70 µM -0.655348317580028 0.262780510672839 no 2474 0.256121759294599 829 3779166 SGTC_185 k048-0037 25.491 µM -0.657609715118978 0.262042125499534 no 2475 0.255394475127641 805 6827589 SGTC_2405 ticlatone 3.52 µM -0.658720895645635 0.261679696028986 no 2476 0.255037506136053 803 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2139 5578692 56.4705 µM -0.659445879116521 0.261443369701516 no 2477 0.254804744512622 814 650991 YMR113W FOL3 SGTC_582 0987-0078 156 µM -0.660096379496548 0.261231416306967 no 2478 0.254595990963062 831 1625765 SGTC_1795 st049545 62.3 µM -0.663206920030263 0.260219126687767 no 2479 0.25359902006259 777 5291882 SGTC_1213 1315-0166 115 µM -0.663747592254529 0.260043377593909 no 2480 0.253425936646817 804 768401 SGTC_1787 fluconazole 80 µM -0.663897092899246 0.259994792221002 no 2481 0.253378088512815 811 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_604 1000-0114 314 µM -0.664403122443052 0.25983037527341 no 2482 0.25321616746899 831 1572745 SGTC_1057 3448-5381 134 µM -0.668046169821294 0.258648277239865 no 2483 0.252052060732735 807 5497911 SGTC_1562 morin hydrate 59.1 µM -0.668627766255464 0.258459818567464 no 2484 0.251866477940333 825 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1145 3546-0597 10.2 µM -0.669147374995884 0.258291506374599 no 2485 0.251700735954725 827 875334 SGTC_1228 0124-0032 52.5 µM -0.670949748635491 0.257708120231586 no 2486 0.251126271273226 820 X1228 SGTC_3028 9087778 49.47 µM -0.671415722599014 0.257557406732522 no 2487 0.250977865818076 814 17217395 SGTC_1318 1280-3875 124 µM -0.671684867230564 0.257470376100597 no 2488 0.25089216859136 843 373245 SGTC_1204 4049-0315 18.3 µM -0.673213270458075 0.256976441365266 no 2489 0.250405809916585 824 588402 SGTC_2795 7780010 54.55 µM -0.673250232097974 0.256964502563813 no 2490 0.25039405441223 823 953673 SGTC_3188 9110789 49.47 µM -0.675655078069204 0.256188345451375 no 2491 0.249629831681745 833 849217 SGTC_2910 7948405 25.97 µM -0.676764469068663 0.255830705167016 no 2492 0.249277702499026 813 2971328 SGTC_298 1391-0729 10 µM -0.676837936413378 0.255807030311365 no 2493 0.249254392729851 829 3237558 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.677581447769691 0.255567498105689 no 2494 0.249018556172688 827 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1990 st072050 59.8 µM -0.677609439845709 0.255558482370087 no 2495 0.249009679603366 821 17233948 SGTC_1163 k060-0048 49.9 µM -0.678751683177247 0.255190728446668 no 2496 0.248647606388332 822 6809982 SGTC_2929 9013348 24.6 µM -0.679970912407469 0.254798493877413 no 2497 0.248261439470142 832 2995952 SGTC_2937 9044753 11.33 µM -0.680004415627307 0.254787720114453 no 2498 0.248250832499381 817 6465530 YGL099W LSG1 SGTC_1346 1488-2224 62.4 µM -0.681433205142978 0.254328480665253 no 2499 0.247798709057532 824 3722427 SGTC_3106 9121286 49.47 µM -0.683382074910646 0.25370277804782 no 2500 0.247182721868771 810 15943471 SGTC_3320 9137005 35.139 µM -0.683431668914986 0.253686865989167 no 2501 0.247167057181876 819 4908713 SGTC_1144 3486-0183 12.5 µM -0.684257490683147 0.253421981076511 no 2502 0.246906292416145 855 6744069 SGTC_1278 0874-0585 172 µM -0.684984995279206 0.253188752188444 no 2503 0.246676694715786 824 766306 SGTC_3248 9135562 49.47 µM -0.685259959239244 0.253100631580456 no 2504 0.246589946912567 828 17650701 SGTC_1750 st081859 2.357 µM -0.685614308415571 0.252987093349553 no 2505 0.24647817813709 839 5291695 SGTC_2047 4141938 200 µM -0.688210075763622 0.252156192592866 no 2506 0.245660249908119 837 3807862 SGTC_2714 st079313 56.9 µM -0.688266740144062 0.252138070486968 no 2507 0.245642411190968 837 2939799 SGTC_1217 1183-1422 255 µM -0.688361481672018 0.252107772281414 no 2508 0.245612586824258 824 2849664 SGTC_1964 st076914 61 µM -0.689570986701803 0.251721143123253 no 2509 0.245232009000187 860 24208661 SGTC_2115 tiliquinol 12.7705 µM -0.689717991781449 0.251674172977887 no 2510 0.245185774612329 836 71208 A bioactive hydroxyquinoline. SGTC_313 3474-0040 5.03 µM -0.690250525819592 0.251504059790829 no 2511 0.245018327234641 830 1043375 YIL048W NEO1 SGTC_1836 st055642 81 µM -0.690882169079716 0.251302365857043 no 2512 0.244819796228345 844 8571 SGTC_2638 epoxomicin 18 µM -0.69287195721148 0.250667553680978 no 2513 0.244194954807345 830 9915668 A protesome inhibitor. SGTC_2832 7992762 51.95 µM -0.693060930461918 0.250607308781097 no 2514 0.244135657393548 829 2985177 SGTC_1867 st057372 64 µM -0.693087720595358 0.250598768675084 no 2515 0.244127251617276 813 688837 SGTC_917 harmaline 728.087 nM -0.693367253412656 0.250509668951222 no 2516 0.244039553626341 810 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2058 5236698 133 µM -0.693504104264028 0.250466054530371 no 2517 0.243996625527219 821 766665 SGTC_260 nsc-65238 3.989 µM -0.693617037977321 0.25043006554178 no 2518 0.24396120295068 832 3246252 SGTC_567 1080-0542 68.4 µM -0.694398041341499 0.250181255451601 no 2519 0.243716310857279 802 5950415 SGTC_1996 st072960 66.8 µM -0.694670934761931 0.250094348669865 no 2520 0.243630773457446 821 1719405 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.695277933318053 0.249901098810892 no 2521 0.24344057022609 830 804 An inhibitor of viral and cellular DNA polymerases. SGTC_882 0843-0131 351 µM -0.697385740730717 0.249230653056471 no 2522 0.242780711406068 833 5425421 SGTC_2315 7733312 200 µM -0.697425029615593 0.249218165239804 no 2523 0.24276842103664 833 726316 SGTC_392 N-ethylmaleimide 8.33 µM -0.698127080622172 0.248995077210586 no 2524 0.242548861857494 825 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2365 9042475 200 µM -0.69849858805424 0.24887706774085 no 2525 0.242432720281914 830 6464479 SGTC_1445 4239-0156 97.7 µM -0.698732341845068 0.248802831026844 no 2526 0.242359659036536 854 4008346 SGTC_384 k007-0144 5.16 µM -0.699854810743424 0.24844651595382 no 2527 0.242008990443241 844 6824886 SGTC_1720 st037298 9.481 µM -0.700771324038716 0.24815578096062 no 2528 0.241722868290664 850 597396 SGTC_2015 5119600 184 µM -0.701116644840765 0.248046285889462 no 2529 0.24161511178812 841 2828786 SGTC_43 0570-0105 72.5 µM -0.701589425830112 0.247896417277567 no 2530 0.241467623955952 829 1114046 YDL195W SEC31 SGTC_2933 9026794 32.47 µM -0.701615891292016 0.247888029320607 no 2531 0.241459369287774 829 17586027 SGTC_96 0929-0093 37.281 µM -0.704180995456065 0.247075765214411 no 2532 0.240660032327962 846 6991579 SGTC_2129 girgensonine 121.053 µM -0.70466187389329 0.24692364921663 no 2533 0.240510341623954 839 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2340 7987427 183.45 µM -0.704912881791894 0.246844267946445 no 2534 0.240432226534215 820 2239331 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.70508906980965 0.246788556630665 no 2535 0.240377404073023 852 279621 SGTC_2847 9005661 71.43 µM -0.705558138326796 0.246640268219423 no 2536 0.24023148245441 811 2991449 SGTC_3124 9127567 49.47 µM -0.705823327133307 0.246556454196329 no 2537 0.240149006745718 822 17592030 SGTC_428 3448-4153 16.5 µM -0.708470617494378 0.245720604150424 no 2538 0.239326526231703 829 3834874 SGTC_2569 tetrandrine 100 µM -0.709575247719675 0.245372280875323 no 2539 0.23898378675952 824 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2335 9018011 154.17 µM -0.711027609879682 0.24491471134936 no 2540 0.238533563339203 828 6458208 SGTC_2801 7907800 81.82 µM -0.7111064181381 0.244889895794387 no 2541 0.238509146546745 848 6620925 SGTC_314 1671-0008 2.74 µM -0.711176797062073 0.244867735655981 no 2542 0.238487342531974 847 3913060 SGTC_1786 berberine 21.6 µM -0.713056535016001 0.244276264071164 no 2543 0.23790538703385 843 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1621 st003705 32.4 µM -0.71340091408428 0.244167986523931 no 2544 0.237798853814961 835 24207032 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.713514783659046 0.244132190047083 no 2545 0.237763634166285 865 368090 SGTC_2854 9024559 71.43 µM -0.714028165395603 0.243970836540725 no 2546 0.237604881680399 846 3163529 SGTC_2778 tioconazole 65.09 nM -0.71642683625617 0.24321770836508 no 2547 0.236863914587284 849 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_554 4483-2211 187 µM -0.716864773883205 0.243080341702325 no 2548 0.236728769711881 845 747107 SGTC_1474 0330-0125 5.35 µM -0.71746957097029 0.242890705704512 no 2549 0.23654220277393 846 X1474 SGTC_740 k014-0057 261 µM -0.717840434447221 0.242774459918281 no 2550 0.236427839371294 842 4012779 SGTC_1988 st071872 53.4 µM -0.718220167089072 0.24265546533261 no 2551 0.236310772521371 830 16414116 SGTC_1485 3909-9022 254 µM -0.718681524463202 0.242510934983982 no 2552 0.236168584736688 851 714516 SGTC_3011 9081274 71.4286 µM -0.719157923507676 0.242361741445865 no 2553 0.236021810660301 848 6625322 SGTC_2409 alverine citrate 63.97 µM -0.721159506286254 0.241735451026989 no 2554 0.235405691347145 831 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_977 1348-1378 135 µM -0.722968915920453 0.241170047927489 no 2555 0.234849490791318 837 X977 SGTC_2602 kawain 100 µM -0.723681410307774 0.240947605584758 no 2556 0.234630674211112 832 5369129 SGTC_3158 9100007 49.47 µM -0.724075902789427 0.240824492163238 no 2557 0.2345095687929 856 19297233 SGTC_318 1488-0629 67.2 µM -0.724368444915001 0.240733217568189 no 2558 0.23441978349316 860 3662576 SGTC_2038 4100038 30.985 µM -0.724747914636179 0.240614849186288 no 2559 0.234303347233771 835 3596803 SGTC_975 1335-0046 28.5 µM -0.727281601514031 0.239825326258075 no 2560 0.233526733259932 857 16486740 SGTC_2647 atorvastatin 60.16 µM -0.727988141578581 0.239605413366039 no 2561 0.23331042270858 829 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2477 5967686 25.23 µM -0.728894386450152 0.239323502916644 no 2562 0.233033134435973 850 776118 SGTC_1294 1000-1494 117 µM -0.730043553731079 0.238966285992203 no 2563 0.232681781298482 835 712797 YDL207W GLE1 SGTC_58 0957-0393 9 µM -0.730129011126925 0.23893973333996 no 2564 0.232655664821052 843 6997992 SGTC_2488 5268135 45.7 µM -0.731752251680817 0.238435679247461 no 2565 0.23215989879961 859 1270356 YLR208W SEC13 SGTC_193 1273-0060 1.558 µM -0.731782559236037 0.238426273583946 no 2566 0.232150647937691 845 2847393 YHR072W ERG7 SGTC_2663 amphotericin b 100 µM -0.735254518286337 0.237350129691254 no 2567 0.231092250922312 840 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1383 3049-0032 20.7 µM -0.736358058674926 0.237008643540297 no 2568 0.230756410933785 866 712864 SGTC_2025 5147754 141 µM -0.736967694230764 0.236820110113171 no 2569 0.230570997762689 829 315777 YLR208W SEC13 SGTC_2755 lomerizine 42.69 µM -0.73700269454506 0.236809288561244 no 2570 0.230560355374424 845 3949 A calcium channel blocker. SGTC_3328 9140624 29.0385 µM -0.737162864574898 0.236759769952838 no 2571 0.23051165669604 842 4904392 SGTC_2544 sphondin 68.51 µM -0.737258886680516 0.236730086224252 no 2572 0.230482464542439 833 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_407 eburnamonine 100 µM -0.739141972404238 0.236148373664147 no 2573 0.229910396170745 840 3195 SGTC_63 0099-0242 26.702 µM -0.739248058370827 0.236115625612027 no 2574 0.22987819165761 855 3898502 YLR359W ADE13 SGTC_649 1123-0311 367 µM -0.742418073116541 0.235138217730886 no 2575 0.228917036374591 839 693629 YIL048W NEO1 SGTC_2984 9022109 38.96 µM -0.742494803925463 0.235114587119016 no 2576 0.228893799417398 879 6459207 SGTC_859 0439-0102 54.6 µM -0.746704049488703 0.233820286907593 no 2577 0.227621112415137 853 610143 SGTC_1908 st060353 56.5 µM -0.749921457274151 0.232833635324332 no 2578 0.226651005228274 873 4227716 SGTC_1663 st014140 55.4 µM -0.750246321764842 0.232734140982239 no 2579 0.226553182525199 850 4207120 SGTC_2526 patulin 37.61 µM -0.751157923456809 0.232455076295139 no 2580 0.226278809724905 858 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_342 k048-0088 23.3 µM -0.751359303279621 0.232393453865369 no 2581 0.226218223987768 863 6820570 SGTC_1826 st055655 41.6 µM -0.751722182001722 0.232282435551126 no 2582 0.226109073953163 856 676168 SGTC_1701 st028638 40.4 µM -0.752563361668886 0.232025200420474 no 2583 0.225856170615364 859 3490878 SGTC_1186 1319-0216 26 µM -0.752612816945081 0.232010081794634 no 2584 0.225841306710218 869 4565136 SGTC_2903 5923464 63.88 µM -0.752636444083659 0.232002859101328 no 2585 0.225834205710775 854 2876576 SGTC_65 0798-0905 34.986 µM -0.75390142206656 0.23161634474696 no 2586 0.225454208318078 879 3602145 SGTC_1206 3978-0017 132 µM -0.757701427687187 0.230457413137643 no 2587 0.224314872066092 851 3873677 SGTC_1647 st011722 22.4 µM -0.758332054355649 0.230265397737722 no 2588 0.224126111228017 854 2854783 SGTC_2603 homopterocarpin 100 µM -0.75882386547544 0.230115711498768 no 2589 0.22397896366081 860 101795 A weak amylase inhibitor. SGTC_1935 st074532 41.6 µM -0.760336585044188 0.22965564586891 no 2590 0.223526709322956 853 2829742 SGTC_2237 6667747 47.222 µM -0.760659967938396 0.229557361838146 no 2591 0.223430095705105 868 729940 YDL015C TSC13 SGTC_3017 9080681 49.47 µM -0.760705324057559 0.229543578880485 no 2592 0.223416547046829 863 16451914 SGTC_932 2857-0803 154 µM -0.760785112250142 0.229519333723253 no 2593 0.223392714066392 866 674898 SGTC_2298 7976326 193.81 µM -0.761724841203395 0.229233887235731 no 2594 0.223112122989347 846 2235818 SGTC_580 1123-0028 41 µM -0.762539883076401 0.228986476234461 no 2595 0.222868924466482 879 1677248 YPR107C YTH1 SGTC_3159 9100096 49.47 µM -0.76306618149783 0.228826794737002 no 2596 0.222711963740368 847 25236875 SGTC_867 0518-0118 155 µM -0.763780402549592 0.228610196599491 no 2597 0.22249905866576 850 6848158 SGTC_581 0958-0271 211 µM -0.764145777834409 0.228499435654685 no 2598 0.222390187342334 847 4591145 SGTC_2926 9010726 65.15 µM -0.764256473081785 0.228465885121081 no 2599 0.222357209341663 870 2994293 SGTC_2838 9002687 71.43 µM -0.764281512054649 0.228458296462752 no 2600 0.222349750191818 870 6457060 SGTC_1444 4112-3581 28 µM -0.767621047811982 0.227447440331528 no 2601 0.221356177054985 864 2877249 SGTC_343 4130-2827 29.8 µM -0.767831410609323 0.227383849315317 no 2602 0.221293675381569 852 1118244 SGTC_1488 4013-0813 75.9 µM -0.768815155351253 0.227086604006235 no 2603 0.221001525322414 845 2910057 SGTC_2595 hexamethylquercetagetin 100 µM -0.76917859958148 0.226976842249596 no 2604 0.22089364643052 885 386331 SGTC_1771 st048882 4.1505 µM -0.775075955288807 0.225200001653211 no 2605 0.219147389359953 867 4580403 SGTC_1547 harmine 94.2 µM -0.77621840053792 0.224856702520095 no 2606 0.218810021680537 852 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2708 st078559 56 µM -0.777787576324482 0.22438565695582 no 2607 0.218347126615085 828 17250902 SGTC_2023 5144124 124 µM -0.777936197803073 0.224341071832148 no 2608 0.218303313659194 860 2830192 SGTC_679 0422-0091 41.4 µM -0.780497206226916 0.223573582419844 no 2609 0.217549135669639 878 627384 YHR062C RPP1 SGTC_2082 5219693 150 µM -0.780853716848761 0.223466860959065 no 2610 0.2174442680897 855 2834649 SGTC_2861 9024595 19.48 µM -0.78127206808597 0.223341664474181 no 2611 0.217321247319682 831 16482810 SGTC_244 nsc-207895 1.295 µM -0.78466677714575 0.222327235405366 no 2612 0.216324483289335 827 42640 SGTC_2749 bexarotene 57.39 µM -0.784769871377456 0.222296469297186 no 2613 0.216294253933997 876 82146 An retinoic acid receptor inhibitor. SGTC_833 3852-0053 558 µM -0.784946052342417 0.222243897753111 no 2614 0.216242599701758 890 3123681 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.78619636311859 0.221871014969764 no 2615 0.215876228218226 858 2724278 An inhibitor of dopamine biosynthesis. SGTC_2024 5144227 134 µM -0.7868904401496 0.221664173259823 no 2616 0.215673002119137 857 3475211 SGTC_3183 9108214 49.47 µM -0.786995612366788 0.221632840531565 no 2617 0.215642217321849 854 4974831 SGTC_364 0083-0097 67.7 µM -0.787434484810255 0.221502119718817 no 2618 0.215513783148085 887 5207356 SGTC_2286 7945697 125 µM -0.788273133850019 0.221252445648556 no 2619 0.215268479467787 867 1245733 SGTC_2017 5132927 60.65 µM -0.789289446443221 0.220950095242028 no 2620 0.214971426715552 857 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2555 cholic acid 100 µM -0.789876564794635 0.220775536863154 no 2621 0.214799929467468 859 6708657 Influences liver metabolism. SGTC_117 lucigenin 22.078 µM -0.789964074296206 0.220749525846516 no 2622 0.214774374753793 884 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1174 0739-0097 51.1 µM -0.790407149874846 0.220617854561054 no 2623 0.214645013982858 878 728447 SGTC_3095 9117207 49.47 µM -0.791323305060933 0.220345738270846 no 2624 0.214377676105371 853 17015229 SGTC_2020 4017018 200 µM -0.791514536090985 0.220288963138028 no 2625 0.214321898536845 885 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_891 0929-0073 133 µM -0.79217030720024 0.220094333068111 no 2626 0.214130689730281 882 5603632 SGTC_726 3448-4391 34.2 µM -0.792342329285816 0.220043293982366 no 2627 0.214080548215539 869 1356692 SGTC_704 1310-0270 142 µM -0.796561179732405 0.218793684785608 no 2628 0.212852965353591 871 5718033 SGTC_3349 9149703 23.001 µM -0.796889538298865 0.21869659767226 no 2629 0.212757593641262 857 4910494 SGTC_2327 6189656 200 µM -0.798840930729059 0.218120133321173 no 2630 0.212191326806617 883 5349088 SGTC_3238 9133470 49.47 µM -0.799177310670317 0.218020851288663 no 2631 0.212093803150416 848 3534688 SGTC_2597 laccaic acid a 100 µM -0.799834073089896 0.217827083958912 no 2632 0.211903469397835 888 5491415 A textile dye. SGTC_1397 3532-0190 20.1 µM -0.801931922836628 0.217208812457492 no 2633 0.21129616947136 840 5322280 SGTC_2002 4023503 131 µM -0.804109125008931 0.216568227689773 no 2634 0.210666977544665 878 4736863 YCR052W RSC6 SGTC_2431 5490079 200 µM -0.805355477521432 0.216202013530073 no 2635 0.210307288109043 891 5722345 SGTC_2307 7538926 6.34 µM -0.806833251839413 0.215768265975001 no 2636 0.209881279409212 884 96582 SGTC_943 3253-1379 105 µM -0.807137191109235 0.21567911810265 no 2637 0.209793723565579 862 668464 SGTC_1178 0988-0033 191 µM -0.807180565649945 0.215666397736687 no 2638 0.209781230404403 864 5392207 SGTC_926 2268-1401 59.4 µM -0.808484565831652 0.215284179328137 no 2639 0.209405843741105 877 2931578 SGTC_126 0417-1624 672.48 µM -0.809119853820009 0.215098111142558 no 2640 0.209223104655323 890 41912 YDL195W SEC31 SGTC_2341 7987486 176.74 µM -0.809891332458599 0.214872279940954 no 2641 0.209001316917433 848 1258686 SGTC_1160 4092-0570 10.5 µM -0.811519270413225 0.21439619376053 no 2642 0.208533765502809 879 4994975 SGTC_1292 0kpi-0043 232 µM -0.811520783487424 0.214395751551488 no 2643 0.208533331227866 865 3333905 SGTC_3051 9093778 49.47 µM -0.813635315378582 0.213778279792556 no 2644 0.207926950168539 905 17217378 SGTC_3319 9138450 16.7555 µM -0.814001603126924 0.213671424183981 no 2645 0.207822016287779 868 2029690 SGTC_540 1187-0821 17.3 µM -0.814441960133121 0.213543001854619 no 2646 0.207695904504204 874 847520 SGTC_2543 pimpinellin 60.67 µM -0.816144013336897 0.213047051235868 no 2647 0.207208886706787 874 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_505 gw-5074 63.9 µM -0.816297532202306 0.213002351398631 no 2648 0.20716499274558 885 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2845 9003024 42.97 µM -0.816489557320604 0.212946447462397 no 2649 0.20711009685767 870 2990173 SGTC_3180 9109287 49.47 µM -0.818212489381958 0.212445236452604 no 2650 0.206617932420096 862 18891271 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.81947702569763 0.212077814403884 no 2651 0.206257152237116 867 6708514 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.819946257670153 0.21194156954341 no 2652 0.206123372441341 874 23665772 A membrane-active detergent. SGTC_559 1550-0661 158 µM -0.821702705889852 0.211432026954938 no 2653 0.205623059391625 880 5830875 SGTC_2311 7694451 200 µM -0.822448190642227 0.211215980165036 no 2654 0.205410930913696 871 2163142 SGTC_2650 prasterone 100 µM -0.822784602131427 0.211118528091795 no 2655 0.205315247240645 862 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_199 4063-0024 41.6 µM -0.824534534602805 0.210612030826558 no 2656 0.204817950773377 869 306215 SGTC_192 3455-0609 60.9 µM -0.824579279903869 0.210599089183826 no 2657 0.204805244436253 859 3769639 SGTC_624 k048-0052 28 µM -0.827822400671716 0.209662327504507 no 2658 0.203885543306212 871 6835531 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.830618864617994 0.20885655162843 no 2659 0.203094487150995 892 23847180 SGTC_1034 k072-0165 12.7 µM -0.831672532086446 0.208553420719894 no 2660 0.202796904486261 898 5835461 SGTC_3001 9076041 71.4286 µM -0.832964485870985 0.208182091168986 no 2661 0.202432379423471 869 16004211 SGTC_2342 7990637 118.86 µM -0.833112093198964 0.208139691153457 no 2662 0.202390756934182 908 2033102 YER133W GLC7 SGTC_253 dyclonine 31.25 µM -0.834487168506146 0.207744947474756 no 2663 0.202003257531224 869 3180 An oral anasthetic. SGTC_1698 5-fluorocytosine 1.055 µM -0.838364104045221 0.206634377046455 no 2664 0.200913121608502 875 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1774 st048371 48.465 µM -0.838426272634066 0.206616597187415 no 2665 0.200895669541568 894 4242727 SGTC_900 1112-0045 141 µM -0.839942611283963 0.206183213673757 no 2666 0.200470282219587 866 56211 YIL048W NEO1 SGTC_1841 st054148 70 µM -0.839966150316133 0.206176490252753 no 2667 0.200463682944732 894 675442 SGTC_1949 st076024 69.1 µM -0.840132339115767 0.206129025675514 no 2668 0.200417094870577 893 2921930 SGTC_3284 9108171 64.8615 µM -0.84032192043038 0.20607488795889 no 2669 0.200363957062846 851 8687505 SGTC_2610 ononetin 44.17 µM -0.840608785323906 0.205992985527101 no 2670 0.200283567704242 911 259632 SGTC_1926 methyl fluorone black 53.6 µM -0.840784548904619 0.205942813029824 no 2671 0.200234322311051 838 72721 Reacts with homocysteine. SGTC_1380 2291-0730 164 µM -0.841424638395016 0.205760157908283 no 2672 0.200055043716797 888 2999191 SGTC_2532 xanthone 78.9 µM -0.842156995050614 0.205551291507969 no 2673 0.199850041006411 877 7020 An insecticide. SGTC_717 1532-0246 73.2 µM -0.84222557688125 0.205531738578592 no 2674 0.199830849918005 887 9561992 SGTC_1321 1326-2144 215 µM -0.842294690083433 0.205512035270466 no 2675 0.199811511258566 904 3513030 SGTC_620 0109-0052 432 µM -0.843154763866875 0.205266932841708 no 2676 0.19957094702065 894 493037 SGTC_2719 novobiocin 32.65 µM -0.844354467380572 0.204925333505584 no 2677 0.19923567900551 908 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_72 0744-0168 198.391 µM -0.846146653214743 0.204415662907768 no 2678 0.198735468778537 916 677577 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.846368848877521 0.204352526430501 no 2679 0.198673505388141 908 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1958 st076513 41.9 µM -0.846907444757135 0.204199533614343 no 2680 0.198523356270526 901 732122 YGL099W LSG1 SGTC_3070 9117005 49.47 µM -0.847205695721294 0.204114842203074 no 2681 0.198440239678704 898 8779016 SGTC_3261 9137475 49.47 µM -0.84729500431801 0.204089486184901 no 2682 0.19841535524041 824 17027690 SGTC_2502 avocadyne acetate 18.59 µM -0.850861588528369 0.203078415150644 no 2683 0.19742312224404 867 3952079 SGTC_1909 st060837 51.5 µM -0.851541620673408 0.202885976664104 no 2684 0.197234276701667 874 678937 SGTC_2840 9008771 71.43 µM -0.851699069103516 0.202841436749417 no 2685 0.197190568715406 836 2992978 SGTC_207 4185-0010 4.486 µM -0.853343616580324 0.202376566961934 no 2686 0.196734389544372 875 3761753 SGTC_470 aa-861 153 µM -0.856350537028988 0.2015282398412 no 2687 0.195901957716333 881 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2628 lathosterol 100 µM -0.857965402903467 0.20107352671184 no 2688 0.195455783842549 888 6710616 SGTC_2777 climbazole 1.536 µM -0.858221593429078 0.20100144530962 no 2689 0.195385057319722 891 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3290 9121031 71.43 µM -0.85902328301099 0.20077598323765 no 2690 0.1951638353264 884 17014854 SGTC_823 0417-1665 178 µM -0.860902053151336 0.200248204902336 no 2691 0.194645995388494 915 3429856 SGTC_1400 3771-8998 51.5 µM -0.862231899726325 0.19987513287878 no 2692 0.194279959465892 873 670767 SGTC_1615 st002656 86.5 µM -0.862393805418396 0.199829740798751 no 2693 0.194235424093587 893 1584458 SGTC_2586 curcumin 80 µM -0.865464323925047 0.198970060750647 no 2694 0.1933919945467 917 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_416 estradiol valerate 100 µM -0.865804188092518 0.19887504318576 no 2695 0.193298776050102 895 13791 A steroid. SGTC_881 0833-0569 170 µM -0.866079718200392 0.198798031901458 no 2696 0.193223223333935 897 5418700 SGTC_2347 9049783 174.81 µM -0.868188408180656 0.198209243831624 no 2697 0.192645599500106 915 6467988 YPL169C MEX67 SGTC_2401 5128683 200 µM -0.870118381573264 0.197671280682582 no 2698 0.192117856663848 917 708373 SGTC_2899 9053889 58.44 µM -0.871756389583785 0.197215393354645 no 2699 0.191670645167088 876 6470052 SGTC_2685 mycophenolic acid 18.85 µM -0.871806870027817 0.19720135384312 no 2700 0.191656873052358 868 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_809 3998-0021 90 µM -0.872066729335353 0.197129091905243 no 2701 0.191585987620743 904 715485 SGTC_246 cycloheximide 667 µM -0.872308573920174 0.197061853917094 no 2702 0.191520030745388 878 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_90 0870-0863 4.608 µM -0.872941945978084 0.196885828669004 no 2703 0.191347360779763 916 1738164 SGTC_1778 st046819 58.9 µM -0.876424615005168 0.195919635579513 no 2704 0.19039962081288 904 671715 SGTC_1220 1838-0075 193 µM -0.877600929194552 0.195593943059824 no 2705 0.190080162428536 880 5529645 SGTC_122 0236-0016 402.397 µM -0.877650662761159 0.195580180303417 no 2706 0.190066663260758 897 6808838 SGTC_1815 st051655 58.2 µM -0.878727714115503 0.195282272449804 no 2707 0.189774464081878 902 5984156 SGTC_656 4090-1979 187 µM -0.878999176106229 0.195207230735582 no 2708 0.18970086127803 883 22330961 SGTC_2935 9038016 29.96 µM -0.880436014808677 0.194810329526795 no 2709 0.189311576731923 894 6463195 SGTC_1218 1348-1416 30.7 µM -0.880500328329788 0.194792575541568 no 2710 0.189294163693557 887 6787668 SGTC_1947 st076332 61.6 µM -0.88368204904972 0.193915478910436 no 2711 0.188433936634178 902 24208416 SGTC_3034 9090421 49.47 µM -0.884215715877204 0.193768600431256 no 2712 0.188289888086923 869 17173761 SGTC_1950 st077106 7.18 µM -0.884244082914728 0.193760795010763 no 2713 0.188282233094573 884 13831864 SGTC_1109 tnp00067 928.257 nM -0.885068710460919 0.193533975837844 no 2714 0.188059786996642 900 676295 SGTC_2021 4019055 173 µM -0.88510003942805 0.193525361796054 no 2715 0.188051339100539 912 44827708 YER133W GLC7 SGTC_1855 st056195 39.6 µM -0.885174315136012 0.19350494028732 no 2716 0.188031311496811 868 4028379 SGTC_3177 9107506 49.47 µM -0.886210531833288 0.193220177944011 no 2717 0.187752044726536 885 8897194 SGTC_414 piperonyl butoxide 100 µM -0.888689225701124 0.192540047395306 no 2718 0.187085061563364 898 5794 A potent inhibitor of cytochrome P450. SGTC_615 k087-0205 167 µM -0.890163903813444 0.192136104639702 no 2719 0.186688941776798 899 9642773 SGTC_1892 st058411 7.36 µM -0.890882460064842 0.191939466246046 no 2720 0.186496115495619 896 3934738 SGTC_697 0508-1955 564 µM -0.892428558112644 0.191516782592657 no 2721 0.186081634833329 885 6243113 SGTC_1480 1070-0044 41.2 µM -0.893691152598838 0.191172028577731 no 2722 0.185743580206716 894 3124987 SGTC_316 k060-0003 58.6 µM -0.893743903723043 0.191157633060497 no 2723 0.185729464600053 899 6152314 SGTC_1427 4048-4900 550 nM -0.894823877260777 0.190863059807335 no 2724 0.18544062213485 898 24132586 SGTC_1305 1181-0477 144 µM -0.899574994295034 0.189570457217733 no 2725 0.184173234723649 914 6252086 SGTC_1636 st007707 68.9 µM -0.899894658134457 0.189483682360015 no 2726 0.184088156592093 925 403051 SGTC_3330 9141424 71.43 µM -0.900431849548754 0.189337913269009 no 2727 0.183945238882828 884 27261020 SGTC_2461 5755302 26.15 µM -0.900531198889433 0.18931096198395 no 2728 0.183918814945624 944 2788904 SGTC_733 4069-0007 56.1 µM -0.900686965595658 0.189268710666199 no 2729 0.183877390444429 914 5717425 YNL287W SEC21 SGTC_547 1120-0019 610 nM -0.900945762254172 0.18919852557584 no 2730 0.183808579070047 860 3676939 SGTC_2884 9058502 51.95 µM -0.901525747208312 0.189041293129236 no 2731 0.183654425288841 893 6471554 SGTC_930 2810-3379 265 µM -0.90245303742623 0.188790074374326 no 2732 0.183408128906513 936 1015764 SGTC_1409 3909-8004 61.9 µM -0.904033612932856 0.188362343973163 no 2733 0.182988789135863 893 2119279 SGTC_694 1315-0438 43.2 µM -0.904290330917045 0.188292928228748 no 2734 0.182920736247348 890 6793154 SGTC_250 brefeldin a 552.239 µM -0.904822234430789 0.188149153407132 no 2735 0.182779785215508 893 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1026 k007-1105 30.6 µM -0.90504303644637 0.188089489986836 no 2736 0.182721294012209 890 7066794 SGTC_2974 9094440 9.66 µM -0.905782321130646 0.187889811189951 no 2737 0.182525540068943 903 25236134 SGTC_217 ketoconazole 989 nM -0.906119969559328 0.187798656820861 no 2738 0.182436178301865 864 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1559 coumarin 343 70.1 µM -0.906713651794294 0.187638447687069 no 2739 0.182279121118374 905 108770 A hepatotoxic, DNA x-linker. SGTC_3196 9111891 49.47 µM -0.907128489842998 0.187526550987084 no 2740 0.182169426890212 922 18891510 SGTC_1357 1503-1303 39.5 µM -0.907505516588759 0.187424889129062 no 2741 0.182069766777663 887 292895 SGTC_1764 st044502 93.5 µM -0.90786765766634 0.187327273138015 no 2742 0.181974073519478 898 8407 SGTC_3219 9131112 49.47 µM -0.90826976303601 0.187218921509912 no 2743 0.181867856830608 887 17612988 YMR079W SEC14 SGTC_2440 5628896 157.78 µM -0.909091626163534 0.186997582211529 no 2744 0.181650881203624 919 5522048 SGTC_763 3453-1109 128 µM -0.909207990390805 0.186966256777287 no 2745 0.181620173610963 891 1560353 SGTC_3016 9080866 49.47 µM -0.9105581829196 0.186603020242589 no 2746 0.181264106113243 902 17066299 SGTC_1374 2889-5571 141 µM -0.91142529578245 0.186369975150887 no 2747 0.18103566519087 884 2853281 SGTC_2908 7930301 100 µM -0.911583321089513 0.186327523730554 no 2748 0.180994052857193 885 2223178 SGTC_164 4100-3994 89.624 µM -0.912568382082937 0.186063035137437 no 2749 0.180734794821646 925 4615967 SGTC_3097 9117246 49.47 µM -0.913126201362487 0.185913364086494 no 2750 0.180588085765776 891 16423892 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.91547380646845 0.185284286020691 no 2751 0.179971473650242 931 5393153 SGTC_632 0781-2353 4.65 µM -0.916133587032807 0.185107725551671 no 2752 0.179798416729871 930 6811515 YHR007C ERG11 SGTC_1461 k072-0203 53.8 µM -0.917742634164877 0.184677575178521 no 2753 0.179376810767396 896 5418714 SGTC_2205 7238770 200 µM -0.919223288268265 0.184282297967677 no 2754 0.178989396256134 899 279867 SGTC_1707 st032323 6.317 µM -0.919550023909841 0.184195143182047 no 2755 0.178903976538242 898 3132057 YMR211W DML1 SGTC_125 0133-0007 11.75 µM -0.92143436322422 0.183693007646675 no 2756 0.178411847454658 892 26541 SGTC_2282 7944268 200 µM -0.922795765780579 0.183330754620062 no 2757 0.178056823914388 919 2970414 SGTC_1459 k035-0031 35.7 µM -0.924834497136692 0.182789106100713 no 2758 0.177526001647111 886 3877128 YMR208W ERG12 SGTC_706 4262-0057 46.9 µM -0.926752073481267 0.182280558638622 no 2759 0.177027636922139 925 883298 SGTC_3118 9124250 49.47 µM -0.927699032662633 0.182029748437594 no 2760 0.176781855199037 886 1504786 SGTC_2588 indole-3-carbinol 100 µM -0.927863953741229 0.181986089757935 no 2761 0.176739072265882 913 3712 Induces cell cycle arrest. SGTC_1419 3993-2473 62.6 µM -0.927931129451244 0.181968308566459 no 2762 0.176721647783216 920 704026 SGTC_2041 5107442 45.335 µM -0.928211018102768 0.181894234646408 no 2763 0.176649060092485 901 793005 SGTC_1863 st057641 20.1 µM -0.928770226197808 0.181746293939418 no 2764 0.176504088803732 929 3921635 SGTC_556 4058-0063 51.5 µM -0.929920572207891 0.181442202147313 no 2765 0.176206105314949 929 6615692 SGTC_994 3910-0338 138 µM -0.930044477346199 0.18140946707052 no 2766 0.176174028163696 899 3479481 SGTC_889 0919-1524 82.7 µM -0.930135083230723 0.181385531819622 no 2767 0.17615057402127 914 3905452 SGTC_2324 6149169 200 µM -0.931944715447901 0.180907897556117 no 2768 0.17568254855468 914 2888231 SGTC_2402 5553605 200 µM -0.932274495948749 0.180820940290842 no 2769 0.175597342321386 928 6758546 SGTC_2886 9058944 51.95 µM -0.933146382744928 0.180591165447416 no 2770 0.175372196862912 863 4949929 SGTC_173 1273-0061 2.693 µM -0.934883317911629 0.180133963985094 no 2771 0.174924217565098 891 2847414 YPL266W DIM1 SGTC_967 1306-0166 352 µM -0.935573771626078 0.179952422620253 no 2772 0.174746342008155 908 4437607 SGTC_562 3772-2733 112 µM -0.937472554691101 0.179453767284008 no 2773 0.174257767444108 914 2876874 YIL048W NEO1 SGTC_2726 cimetidine 79.27 µM -0.938070651898196 0.179296876035411 no 2774 0.174104051409458 912 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2703 st077852 53.4 µM -0.94005288285765 0.178777519453138 no 2775 0.173595217740777 918 6281836 SGTC_1489 4065-0444 182 µM -0.940790431865417 0.178584519110271 no 2776 0.173406132569624 884 2877968 SGTC_2666 tannic acid 100 µM -0.940853944194715 0.178567905470002 no 2777 0.173389856070087 894 16134267 A thiamine antagonist. SGTC_397 arbidol 50 µM -0.941173047465108 0.178484448740497 no 2778 0.173308093214797 908 131410 A RNA synthesis inhibitor. SGTC_2000 st075254 36.4 µM -0.941319104631994 0.178446257851771 no 2779 0.173270677624218 885 17234175 SGTC_136 0097-0015 404.482 µM -0.941554894137552 0.178384614701129 no 2780 0.173210286077748 923 4861337 SGTC_666 0272-0154 136 µM -0.941935145372899 0.178285232759269 no 2781 0.173112922538041 916 6870312 SGTC_633 0437-0093 97.7 µM -0.94325715495005 0.177939985740378 no 2782 0.172774692593879 909 2831118 SGTC_123 0083-0120 66.675 µM -0.943302319087866 0.177928198434432 no 2783 0.17276314500689 939 16001701 SGTC_3093 9117344 49.47 µM -0.94427862902103 0.177673513469614 no 2784 0.172513641911005 894 24824913 SGTC_1201 1889-3372 45.9 µM -0.94447216244087 0.177623054730571 no 2785 0.172464210343792 905 5392199 SGTC_1846 st056244 14.8 µM -0.950553041261977 0.176042233513827 no 2786 0.170915658077914 920 5393182 SGTC_1744 st037937 38.9 µM -0.952190316709408 0.17561812439622 no 2787 0.170500235506237 927 1016152 SGTC_729 4092-0585 94.1 µM -0.954886699640658 0.174921083445017 no 2788 0.169817498250043 905 2169061 SGTC_1571 st070080 73.4 µM -0.955379173357893 0.174793964113453 no 2789 0.169692991106031 902 4315245 SGTC_227 fluconazole 33.516 µM -0.955503408797122 0.17476190521787 no 2790 0.169661591168445 927 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3288 9119690 36.221 µM -0.955579315497892 0.174742319367172 no 2791 0.169642407932226 952 17595618 YKL019W RAM2 SGTC_1646 st011709 75.6 µM -0.955944281256575 0.174648168418173 no 2792 0.169550192758039 922 5757843 SGTC_2504 purpurogallin 52.29 µM -0.956175875655059 0.174588440254174 no 2793 0.169491692943203 903 5281571 An antioxidant. SGTC_1993 st073995 70.8 µM -0.958051915251361 0.174105088104339 no 2794 0.169018290344663 919 3098394 SGTC_2172 5754775 163.918 µM -0.958564651749661 0.173973132277858 no 2795 0.168889053574782 901 2263357 SGTC_2891 9063876 19.48 µM -0.959443729453264 0.173747044347805 no 2796 0.16866762717814 907 6472478 SGTC_3347 9188721 44.724 µM -0.963367384797545 0.172740208800464 no 2797 0.167681593924656 920 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_7 0192-1582 4.227 µM -0.963616379135013 0.172676440970343 no 2798 0.167619145980361 949 252616 SGTC_925 2064-1272 59.6 µM -0.96461873116931 0.172419888914385 no 2799 0.167367906978345 937 6815817 SGTC_2130 NSC 7 2.4545 µM -0.965387882775263 0.172223189469496 no 2800 0.167175284178652 917 21448 SGTC_3152 9099253 49.47 µM -0.965480287154344 0.17219956801883 no 2801 0.167152152469872 892 25236131 SGTC_1013 4112-3890 241 µM -0.966049062842878 0.172054216686988 no 2802 0.167009815553467 919 705171 SGTC_2828 7998861 71.43 µM -0.966140482763295 0.172030861520685 no 2803 0.166986944883226 885 2988188 SGTC_1948 st076329 66.6 µM -0.966312427448281 0.171986940070799 no 2804 0.16694393467399 912 24208413 SGTC_2629 bisabolol 100 µM -0.967359456432019 0.171719642141949 no 2805 0.166682185292271 915 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3065 9113888 49.47 µM -0.968533813277891 0.171420154358562 no 2806 0.166388920176845 934 16648368 SGTC_1740 st038286 13.222 µM -0.969843149136152 0.171086637704492 no 2807 0.166062340609907 902 716786 SGTC_702 1488-0190 94 µM -0.970858899804841 0.170828189725622 no 2808 0.165809273653859 903 949357 SGTC_1816 st051957 91.6 µM -0.973980005982635 0.170035618536235 no 2809 0.165033233385801 955 674121 SGTC_908 3448-7491 47.7 µM -0.975462251866395 0.169660045000311 no 2810 0.164665508697633 871 1203031 SGTC_1970 st070122 35.8 µM -0.976579839196331 0.169377221290997 no 2811 0.164388602061778 924 102928 SGTC_1898 st060199 18.6 µM -0.977199693574428 0.16922048755967 no 2812 0.16423514984386 893 688866 SGTC_451 chloral hydrate 100 µM -0.977227850264925 0.169213370190742 no 2813 0.164228181531348 937 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1974 st069448 26.9 µM -0.977468300303066 0.169152597736086 no 2814 0.16416868195675 912 6323587 YNR016C ACC1 SGTC_486 niguldipine 82 µM -0.97828425187944 0.16894647484801 no 2815 0.163966878251161 912 1236 A calcium channel blocker. SGTC_2698 st077697 67.5 µM -0.979460369414892 0.168649652092387 no 2816 0.163676280494133 928 3154499 SGTC_2858 9025781 8.96 µM -0.980288616447413 0.168440824446742 no 2817 0.163471836123333 897 4894980 YPL153C RAD53 SGTC_557 1315-0110 16.2 µM -0.982218141600537 0.167954974446849 no 2818 0.16299619597326 921 6833801 SGTC_3136 9095672 49.47 µM -0.983024550212858 0.167752190144857 no 2819 0.16279767799068 872 17217380 SGTC_2560 caryophyllene 100 µM -0.984195396739574 0.167458042871639 no 2820 0.162509724358368 933 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1045 1348-1485 165 µM -0.986001799769341 0.167004879456371 no 2821 0.162066114841365 926 6810614 SGTC_2164 5685496 200 µM -0.986721932719719 0.166824443943704 no 2822 0.161889487437856 956 759046 SGTC_2738 aclarubicin 5.55 µM -0.987789059669563 0.166557297451176 no 2823 0.161627983332999 914 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_700 3453-2283 142 µM -0.988156187414696 0.166465453903093 no 2824 0.161538080776241 920 565664 SGTC_1361 1608-0041 5.61 µM -0.991241180246794 0.165694980014429 no 2825 0.160783913398967 917 X1361 SGTC_2522 biochanin a 4.94 µM -0.991424292948067 0.165649320407658 no 2826 0.160739221467257 927 5280373 A possible chelator. SGTC_3210 9128157 49.47 µM -0.992755773983359 0.165317557009036 no 2827 0.16041449366158 935 17590849 SGTC_1166 k206-0078 225 µM -0.995518480241032 0.164630549689788 no 2828 0.159742080378697 923 5404595 SGTC_1844 rapamycin 4 nM -0.995989541843826 0.164513594791739 no 2829 0.159627613293239 894 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_611 3453-1652 23.7 µM -0.997529798421488 0.164131556792597 no 2830 0.159253708636445 929 1560575 SGTC_3043 9092303 49.47 µM -1.00123007981647 0.163216110148962 no 2831 0.158357793689513 926 25236084 SGTC_1980 st071811 45.7 µM -1.00147427648313 0.163155813016476 no 2832 0.15829878514321 931 4974850 SGTC_732 3970-1727 52.7 µM -1.00275691885088 0.162839340227616 no 2833 0.157989079840038 936 1275699 SGTC_2748 diazoxide 86.69 µM -1.00358908465456 0.162634229434054 no 2834 0.1577883589903 860 3019 A potassium channel activatior. SGTC_670 4204-0025 119 µM -1.00430261905542 0.162458492604014 no 2835 0.15761638581962 937 719039 SGTC_612 0302-0167 22.4 µM -1.00690396064847 0.161818853513015 no 2836 0.156990464253233 936 235821 SGTC_2302 7771753 200 µM -1.01062424034871 0.160906936345845 no 2837 0.156098154700671 919 2203047 SGTC_2295 7971645 200 µM -1.01285171667886 0.160362544746196 no 2838 0.155565496930247 963 2978226 YKL099C UTP11 SGTC_3305 9127027 53.8275 µM -1.01465844762629 0.159921867720936 no 2839 0.155134333946074 930 41905295 SGTC_1847 st056231 15 µM -1.01616193083783 0.159555759758262 no 2840 0.154776140791206 916 5393180 SGTC_1972 st070201 17.4 µM -1.02128816705102 0.158311614938697 no 2841 0.153558965482178 932 2829099 SGTC_2201 6605497 169.863 µM -1.02139005363484 0.158286951607114 no 2842 0.153534837917512 939 670741 SGTC_376 3970-0862 59.1 µM -1.02180547802406 0.158186417365118 no 2843 0.153436488060411 940 3135186 SGTC_1493 4348-0038 111 µM -1.02209977543153 0.15811522166635 no 2844 0.1533668397301 941 800424 SGTC_89 0302-0250 142.109 µM -1.02375408112056 0.157715407602223 no 2845 0.152975722084614 953 4203518 YLR208W SEC13 SGTC_1521 st012942 49.4 µM -1.0246613717197 0.157496415039499 no 2846 0.152761497798997 915 24207259 SGTC_1117 retinoic acid 1.10837 µM -1.02478438398229 0.157466738983401 no 2847 0.152732468169219 963 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1395 3486-0190 4.35 µM -1.02490741254409 0.157437062671064 no 2848 0.152703438352997 946 6748079 SGTC_3249 9135183 49.47 µM -1.02532282919624 0.157336885180801 no 2849 0.152605443695747 909 4902779 SGTC_1629 st005085 44.9 µM -1.02774487286081 0.156753645272209 no 2850 0.152034926928937 915 24207091 SGTC_1423 4048-0112 5.59 µM -1.02851270649936 0.156569044615658 no 2851 0.151854358437939 918 X1423 SGTC_1680 diphenhydramine 100 µM -1.02852018048197 0.156567248442961 no 2852 0.151852601510633 912 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2670 beta-carotene 100 µM -1.02930579056515 0.156378523636254 no 2853 0.151668001552665 892 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2352 9027995 87.8 µM -1.03074089764579 0.156034159054597 no 2854 0.151331170265516 943 2997347 SGTC_3195 9113082 49.47 µM -1.03484991642415 0.155050935634535 no 2855 0.150369503612356 927 17018038 SGTC_2986 9022445 71.43 µM -1.03844605649727 0.154193800176956 no 2856 0.149531218451169 906 6459286 SGTC_3078 9116413 49.47 µM -1.03987055991511 0.15385513982298 no 2857 0.149200020898882 932 17177322 SGTC_1447 4239-0816 81.9 µM -1.04083790490178 0.153625444832047 no 2858 0.148975392338092 930 1341554 SGTC_1727 st034309 9.9045 µM -1.04111434167761 0.15355984696309 no 2859 0.148911242090001 962 870305 SGTC_1762 st045503 25.4615 µM -1.043629506927 0.152963855757709 no 2860 0.148328417852653 967 4645554 SGTC_87 0100-0052 35.5 µM -1.04626245811354 0.15234159924383 no 2861 0.14771993662584 963 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1868 st057644 42.7 µM -1.04961685793687 0.15155127695822 no 2862 0.14694715161053 960 688665 SGTC_296 1222-0039 74.9 µM -1.05102043640938 0.151221393428702 no 2863 0.146624601936874 943 5984176 SGTC_493 zm226600 134 µM -1.0528384944749 0.150794805206662 no 2864 0.146207509488989 940 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.05289147993543 0.150782384751738 no 2865 0.146195365714237 972 442882 SGTC_2949 9072542 2.23 µM -1.05385088823064 0.150557605265896 no 2866 0.145975595442687 964 16457352 SGTC_3119 9125183 49.47 µM -1.0542063776487 0.150474374455233 no 2867 0.145894220388185 909 22695334 SGTC_3292 9120825 59.784 µM -1.05678941054273 0.14987052906109 no 2868 0.145303854128088 918 24824900 SGTC_1776 st049249 45.9 µM -1.0573306800886 0.149744199522879 no 2869 0.145180347985837 966 1822314 SGTC_2220 6782180 200 µM -1.05803516880666 0.149579881894854 no 2870 0.145019704553644 926 833803 SGTC_22 0964-0034 14.468 µM -1.05986650729955 0.149153296664896 no 2871 0.144602667347824 957 138402 SGTC_2958 9077254 16.72 µM -1.06172397475876 0.148721455807931 no 2872 0.144180506046784 948 16457351 SGTC_730 1436-0052 41.2 µM -1.06541374345648 0.147866106133704 no 2873 0.143344370084895 928 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3122 9126309 49.47 µM -1.06660556237161 0.147590527840799 no 2874 0.14307499383413 972 17591206 SGTC_2385 9074692 200 µM -1.0672564470415 0.147440172392532 no 2875 0.142928024632372 947 17046906 SGTC_653 0203-0016 55.2 µM -1.06745242482949 0.147394921305747 no 2876 0.142883793006651 965 295302 SGTC_381 3461-2219 42.7 µM -1.06971897096453 0.146872254177092 no 2877 0.142372912242022 970 2883159 SGTC_264 promethazine 12.5 mM -1.07618971004179 0.145386945135165 no 2878 0.140921210395244 954 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2077 5212015 200 µM -1.07856625867135 0.144843972201236 no 2879 0.140390564782454 935 780900 SGTC_1814 st052110 31.539 µM -1.07865519059104 0.144823680356891 no 2880 0.14037073406645 947 674163 SGTC_1043 0916-0009 19.3 µM -1.07876220279941 0.144799265620333 no 2881 0.140346874191741 951 3101130 SGTC_21 0849-0113 22.993 µM -1.07887031963 0.144774601680149 no 2882 0.140322770823029 946 1560156 SGTC_1550 gossypolone 36.6 µM -1.07888429294314 0.144771414251928 no 2883 0.140319655843277 950 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_711 k292-0785 179 µM -1.07888988415257 0.144770138864083 no 2884 0.140318409444504 927 4146315 SGTC_42 0133-0086 60.653 µM -1.07890905685372 0.144765765515341 no 2885 0.140314135501229 956 162923 Model of phenazepam hydroxylation. SGTC_2175 5807670 165.306 µM -1.07950908404202 0.144628942536521 no 2886 0.140180423221079 897 241186 SGTC_278 4092-0821 23.9 µM -1.08193592851782 0.14407644300294 no 2887 0.139640499397017 955 877900 SGTC_1195 1502-0147 41.1 µM -1.0821972092546 0.144017044364474 no 2888 0.139582454146561 931 817940 SGTC_2428 5615643 7.78 µM -1.08349082740366 0.143723201115338 no 2889 0.139295310031483 952 2253075 SGTC_1687 st020778 55.3625 µM -1.08557561462457 0.143250497000437 no 2890 0.138833396634232 950 4259299 SGTC_2356 9061756 188.97 µM -1.08602692591973 0.143148305210093 no 2891 0.138733539889761 943 20104043 SGTC_1415 3966-0071 78.1 µM -1.08775132094277 0.142758298825973 no 2892 0.138352452368777 945 2893185 SGTC_291 SEC14.278 35.5 µM -1.08852007447544 0.142584661566324 no 2893 0.138182789687604 936 1068044 SGTC_1583 clindamycin 39.6 µM -1.08875999156365 0.142530501089945 no 2894 0.138129869424848 964 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1802 st050112 57.9 µM -1.09260602665265 0.141664170784275 no 2895 0.137283407754767 952 4662563 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.0926978767773 0.141643524987392 no 2896 0.137263236158453 928 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_922 1866-0035 480 µM -1.09620320891361 0.140857129957359 no 2897 0.136494927825019 935 3156169 SGTC_3040 9091894 49.47 µM -1.0968919991354 0.140702953897443 no 2898 0.136344303337202 918 25236966 SGTC_1066 ketoconazole 628 nM -1.10435225912338 0.139040416454528 no 2899 0.134720180811215 956 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3075 9116269 49.47 µM -1.10532296343466 0.138825079873938 no 2900 0.13450983554532 944 17015205 YNL244C SUI1 SGTC_2902 5787006 60.46 µM -1.10543043675552 0.138801252459026 no 2901 0.134486560651036 940 591003 SGTC_803 4488-1585 147 µM -1.10662735756485 0.138536076894194 no 2902 0.134227537080059 942 747204 SGTC_380 3970-0968 6 µM -1.10673094885792 0.138513142678711 no 2903 0.134205135189047 944 2891601 SGTC_2753 fluvastatin 17.09 µM -1.10771296660766 0.138295860957862 no 2904 0.133992898814611 971 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1956 st077085 54 µM -1.10875006410904 0.138066644650139 no 2905 0.133769008971837 958 24208685 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.11074687148464 0.137626046025256 no 2906 0.133338660385467 949 6708760 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.11179588418446 0.137394964673506 no 2907 0.133112960956246 953 688664 SGTC_815 1582-0027 36.9 µM -1.11584610788924 0.136505249783265 no 2908 0.132244006755948 958 3128206 SGTC_2278 7948257 134.34 µM -1.11838698615491 0.135949109419767 no 2909 0.131700875009319 947 1247028 SGTC_1505 k297-0037 20.6 µM -1.11921640227512 0.135767905439269 no 2910 0.131523914810451 949 4089396 SGTC_3144 9087057 49.47 µM -1.11935237782226 0.13573821441486 no 2911 0.131494919394025 951 17249618 SGTC_959 1222-0044 107 µM -1.12154280762232 0.13526053458617 no 2912 0.131028440314757 934 6083612 SGTC_834 0312-0008 75.7 µM -1.12202502111115 0.135155530432626 no 2913 0.130925900738601 972 6385573 YIL048W NEO1 SGTC_2068 5226020 147 µM -1.12378292593788 0.134773212108149 no 2914 0.130552563262204 980 1810509 SGTC_1158 4092-0494 91.8 µM -1.1243664747444 0.134646463074534 no 2915 0.130428794179008 959 1148199 SGTC_1574 spiramycin 23.7 µM -1.12498607708336 0.134511972649834 no 2916 0.130297467100788 956 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2043 5101342 149 µM -1.12656107586967 0.134170519824945 no 2917 0.12996405202009 976 678451 SGTC_945 3381-0768 11.3 µM -1.12731517437353 0.134007245537585 no 2918 0.129804624451211 962 1126236 YIL048W NEO1 SGTC_1112 tnp00069 1.16933 µM -1.13264948344416 0.132856181850665 no 2919 0.128680739790926 958 145826 SGTC_3212 9128307 49.47 µM -1.13530615997437 0.132285457981771 no 2920 0.128123531068022 971 27243542 SGTC_1482 3346-2049 8.48 µM -1.13542986553929 0.13225892401941 no 2921 0.128097626081747 957 3826804 SGTC_1702 st027038 51 µM -1.13599194397486 0.132138408406854 no 2922 0.127979967948196 968 5521182 SGTC_961 1252-1571 372 µM -1.13657650572242 0.132013152474764 no 2923 0.127857683121574 972 6813498 SGTC_2796 7949634 45.45 µM -1.13961530868903 0.131363337727626 no 2924 0.127223302331578 956 2971588 SGTC_198 3454-2873 16.191 µM -1.14411646620779 0.130404878707441 no 2925 0.12628766986082 955 710957 SGTC_2312 7706453 155.7 µM -1.14631905751517 0.129937634357386 no 2926 0.125831580169383 962 976098 SGTC_3329 9141233 27.5565 µM -1.14774636758379 0.129635473039836 no 2927 0.125536641819017 945 4909101 YNL103W MET4 SGTC_2976 9009005 19.48 µM -1.15188120073437 0.128762878102615 no 2928 0.124684947158242 930 2993148 SGTC_2860 9025725 38.96 µM -1.15420486306277 0.128274296178879 no 2929 0.124208094650947 982 40546248 SGTC_2283 7944793 200 µM -1.15509895653563 0.128086644143183 no 2930 0.124024952746411 937 2970533 SGTC_1202 1988-0068 29.6 µM -1.15671411186302 0.127748139441031 no 2931 0.123694591099408 962 2850480 SGTC_1402 3909-7673 35.9 µM -1.15703379189969 0.127681214590276 no 2932 0.123629277295366 973 5328014 SGTC_2659 sanguinarine 24.21 µM -1.15954442693957 0.127156461729114 no 2933 0.123117169198175 939 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1124 fisetin 1.16336 µM -1.15983669145222 0.127095472589118 no 2934 0.123057651148112 961 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3066 9117245 49.47 µM -1.16074953258347 0.126905113925086 no 2935 0.122871885990223 949 17176980 SGTC_400 oxethazaine 37.5 µM -1.16077540791844 0.126899720925044 no 2936 0.122866623170733 963 4621 A local anesthetic. SGTC_2508 celastrol 40.54 µM -1.16330866623495 0.12637250531369 no 2937 0.122352145405659 919 122724 Celastrol is a natural product and antioxidant. SGTC_1096 rimcazole 32.2 µM -1.16966102349071 0.12505718614681 no 2938 0.121068704611305 955 18528119 A dopamine reuptake inhibitor. SGTC_92 0063-0024 660.874 µM -1.17459933863912 0.124041286358053 no 2939 0.120077524014205 996 3594437 SGTC_38 0929-0051 58.268 µM -1.17825207835064 0.123293577396922 no 2940 0.119348063143971 968 1379719 SGTC_91 0417-1751 58.384 µM -1.1782891425577 0.123286006643319 no 2941 0.119340677394578 995 6795624 SGTC_890 0929-0006 47.2 µM -1.17871390296627 0.123199268124494 no 2942 0.119256058818699 972 1378169 SGTC_1752 st044819 83.042 µM -1.18149179454131 0.12263306107831 no 2943 0.118703705606445 966 441209 YML126C ERG13 SGTC_654 1124-0271 80.9 µM -1.1833086741241 0.122263722335124 no 2944 0.118343418166149 976 5403748 SGTC_1478 0453-0656 35.7 µM -1.18414868961365 0.122093226616565 no 2945 0.118177104590881 1006 5258496 SGTC_2265 7929201 200 µM -1.18764581757971 0.121385218401355 no 2946 0.117486489348927 962 1265108 SGTC_2513 baicalein 25.65 µM -1.19037779037254 0.120834131079144 no 2947 0.116948969158753 994 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1671 st016596 74.5 µM -1.1910097243217 0.120706909954822 no 2948 0.116824883696527 980 2829167 SGTC_767 0929-0023 86 µM -1.1933011280383 0.120246394832808 no 2949 0.116375730437202 975 1204563 SGTC_793 0488-0545 106 µM -1.19354209519236 0.12019803845904 no 2950 0.116328568152027 977 292548 SGTC_641 4092-0595 30 µM -1.19471938339688 0.11996198173585 no 2951 0.116098343329423 991 786260 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.19533062143942 0.119839552047387 no 2952 0.115978940180496 994 5106787 A p450 inhibitor. SGTC_1031 k035-0009 16 µM -1.19535806650458 0.119834056926146 no 2953 0.115973580931821 984 5180959 SGTC_20 0481-0013 4.944 µM -1.19623912578517 0.119657743368889 no 2954 0.115801628264155 966 182045 SGTC_2950 9072895 21.46 µM -1.19671569782625 0.119562450233442 no 2955 0.115708693176052 949 17332245 SGTC_1076 itraconazole 331 nM -1.19682857349151 0.119539887982102 no 2956 0.11568668934449 976 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2960 9079389 5.97 µM -1.1993034155558 0.119045956698347 no 2957 0.115204993746626 977 16457355 SGTC_74 000s-0487 160.283 µM -1.20079997433566 0.118747972183054 no 2958 0.114914400916743 968 677548 SGTC_1347 1493-0251 600 nM -1.2014314735544 0.118622390605491 no 2959 0.114791936723447 921 3986378 SGTC_3337 9144342 33.5465 µM -1.20407891481589 0.11809693499397 no 2960 0.114279539342082 967 17682949 SGTC_2382 9035899 200 µM -1.2051324296733 0.117888295320733 no 2961 0.114076091145363 987 6462679 SGTC_3046 9092212 49.47 µM -1.20582001901426 0.11775226481716 no 2962 0.113943447419161 1002 25236637 SGTC_322 k048-0136 19.3 µM -1.2071204846654 0.117495288610073 no 2963 0.113692873506605 987 6823282 SGTC_2467 5474540 200 µM -1.20734541382796 0.117450882190184 no 2964 0.113649573997822 949 5413519 SGTC_305 1682-2595 20.8 µM -1.20871268346646 0.117181205983945 no 2965 0.113386623583154 965 226033 SGTC_3340 9146634 11.102 µM -1.21057552924023 0.116814490193809 no 2966 0.11302906376018 964 4907387 SGTC_492 tmb-8 126 µM -1.21109089094869 0.116713181021717 no 2967 0.112930286053215 963 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_818 4072-2707 53.5 µM -1.21298687582996 0.116341006846593 no 2968 0.112567419146671 961 882871 SGTC_2881 9058953 51.95 µM -1.21446566204246 0.11605131212678 no 2969 0.112284977297563 949 17122249 SGTC_3090 9117696 49.47 µM -1.21816452183972 0.115328947451929 no 2970 0.111580729396128 952 7923821 SGTC_2398 5228213 48.84 µM -1.22027861387642 0.114917516383043 no 2971 0.111179637068662 986 80771 YMR134W ERG29 SGTC_2661 dactinomycin 12.96 µM -1.22333941688579 0.11432369410849 no 2972 0.110600762623676 982 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1721 st082152 9.2685 µM -1.22420626105644 0.114155916546549 no 2973 0.110437213936266 975 5296051 SGTC_1641 st009299 47.1 µM -1.22573574038702 0.113860313891384 no 2974 0.110149067967153 960 4046054 SGTC_2681 menadione 3.18 µM -1.22582441744787 0.113843192010432 no 2975 0.110132378224691 986 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.23007841217627 0.113023979473788 no 2976 0.109333871597066 949 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1981 st071826 47 µM -1.23133486480428 0.112782825049989 no 2977 0.109098823599003 957 11838600 SGTC_232 clozapine 119 µM -1.23172792723846 0.112707458986252 no 2978 0.10902536697038 979 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.23222069583226 0.112613026007287 no 2979 0.108933327197278 990 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2859 9028643 45.46 µM -1.23266937560787 0.112527091265604 no 2980 0.108849570969725 939 17151580 SGTC_2418 pentamidine 31.67 µM -1.23536261865413 0.11201224420114 no 2981 0.108347789239861 930 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_377 3970-0964 33.1 µM -1.23543042732944 0.111999303496466 no 2982 0.108335177232523 993 16481235 SGTC_905 2-aminofluorene 215 µM -1.2408615904528 0.110966281705558 no 2983 0.10732844198565 986 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3342 9147791 14.508 µM -1.24371543088026 0.110426216996384 no 2984 0.106802157368378 972 1838168 SGTC_1078 idebenone 36.1 µM -1.246009715947 0.109993411810656 no 2985 0.10638041411262 994 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1862 st057513 3.81 µM -1.24629009700719 0.109940602930961 no 2986 0.106328956095117 979 5393163 SGTC_2953 9074162 66.49 µM -1.24783535674272 0.109649884615577 no 2987 0.106045678848397 960 16451992 SGTC_921 1561-0023 372 µM -1.24812172469384 0.109596069294524 no 2988 0.105993241778818 978 24050882 SGTC_1101 ebselen 5.29 µM -1.24827209310267 0.109567819103488 no 2989 0.105965715199805 983 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1063 disulfiram 1.84 µM -1.25224393110846 0.108823509562785 no 2990 0.105240496308135 988 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1700 st030840 7.9285 µM -1.25415325074526 0.108467005972341 no 2991 0.104893154113471 988 5499307 SGTC_1765 st044815 90.4 µM -1.25562225553334 0.108193289415426 no 2992 0.104626479212392 986 645695 SGTC_134 0269-0018 6.916 µM -1.25582171321529 0.108156163257626 no 2993 0.104590308681991 986 4378915 SGTC_3060 1327-0027 12.5 µM -1.25772993120786 0.107801439613373 no 2994 0.104244721855495 955 16000455 YPR107C YTH1 SGTC_1311 1190-0148 100 µM -1.2601054785135 0.107361014871304 no 2995 0.103815657103361 983 1961333 SGTC_1339 1486-1321 22.7 µM -1.26658141407675 0.106166972394231 no 2996 0.102652500798679 989 3469382 SGTC_1438 4092-1045 4 µM -1.26856048570318 0.105803989303894 no 2997 0.102298932509259 977 1351342 SGTC_872 0588-0139 234 µM -1.26999203129434 0.105541988101384 no 2998 0.102043734339071 979 2047100 SGTC_1012 4112-3522 18 µM -1.27015048089972 0.105513017549942 no 2999 0.102015516409812 971 3112398 SGTC_1704 st028805 70.8 µM -1.27328270474717 0.104941509237653 no 3000 0.101458870850545 985 2876101 SGTC_1123 mangostin 811.285 nM -1.27541260922036 0.104554167161834 no 3001 0.10108161899406 942 5281650 An antioxidant. SGTC_2443 5493264 126.67 µM -1.27670279564672 0.104320039569401 no 3002 0.100853597046881 1008 5340055 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.28000595461921 0.103722354001118 no 3003 0.100271520853946 1000 115019 SGTC_1620 st003704 16.5 µM -1.28081205114054 0.103576873825875 no 3004 0.100129845051557 990 2834414 SGTC_412 gemfibrozil 100 µM -1.28125941796981 0.103496199270324 no 3005 0.100051281010586 983 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2959 9079155 11 µM -1.28148619677725 0.103455321217079 no 3006 0.100011472590166 990 16189457 SGTC_3233 9132340 49.47 µM -1.28499192802387 0.102824885271758 no 3007 0.0993975523856658 1003 17682950 SGTC_1252 0493-0875 34.8 µM -1.28642844308331 0.102567364550046 no 3008 0.0991467885646295 975 3960963 SGTC_1137 ixabepilone 100 µM -1.29896070411657 0.100340600496474 no 3009 0.0969787075958765 987 154225 A novel microtubule stabilizer. SGTC_1251 0490-5699 265 µM -1.30376198330447 0.0994969119704159 no 3010 0.0961573741948803 992 3883818 SGTC_2199 6590217 200 µM -1.3058885104808 0.0991248964397224 no 3011 0.0957952371811572 939 703109 SGTC_1025 k007-0731 70 µM -1.30647926007081 0.0990217312478535 no 3012 0.0956948137530182 997 6256118 SGTC_1470 k295-0292 231 µM -1.30656365616528 0.0990069992017576 no 3013 0.0956804733142365 1016 5045612 SGTC_13 0199-0087 65 µM -1.30762752851154 0.0988214288337116 no 3014 0.0954998375333171 996 4589825 SGTC_2351 9026858 72.31 µM -1.30848180290585 0.0986726027993077 no 3015 0.0953549713516609 1020 1409300 SGTC_1390 3413-2614 145 µM -1.30927299015002 0.0985349137769315 no 3016 0.0952209477221714 1011 3421432 SGTC_44 0929-0055 61.211 µM -1.31101441651341 0.0982323518202602 no 3017 0.0949264465153032 964 1379590 SGTC_2880 9042983 58.44 µM -1.31115517582922 0.0982079255271565 no 3018 0.0949026713574518 1006 6464714 SGTC_464 bw-b 70c 158 µM -1.31277538523705 0.0979270870886185 no 3019 0.0946293233376893 1000 5353454 SGTC_2296 7971656 126.45 µM -1.3164858095678 0.0972861601969614 no 3020 0.0940055190955315 992 666570 SGTC_3338 9144300 39.5675 µM -1.31797671526096 0.0970294945539857 no 3021 0.0937557213687312 984 4901274 SGTC_1192 1488-0095 21.4 µM -1.32736576005647 0.095424544644123 no 3022 0.0921938601789869 1015 915875 SGTC_766 1391-0721 126 µM -1.33037295497219 0.0949146537066555 no 3023 0.0916977103913875 1015 1020919 YIL115C NUP159 SGTC_957 1187-1561 14.1 µM -1.33154121163416 0.094717109939425 no 3024 0.0915054970292922 982 1538454 SGTC_1668 st014914 51.6 µM -1.33536120540319 0.0940732919606154 no 3025 0.0908790777340493 1010 2839556 SGTC_1712 st032288 53.4 µM -1.33798600468494 0.0936327861902108 no 3026 0.090450499525925 1001 2883011 SGTC_1075 aripiprazole 15.2 µM -1.34054042958959 0.0932055551588092 no 3027 0.0900348547085249 1014 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2233 sulbentine 40.3845 µM -1.34120619505096 0.0930944419918611 no 3028 0.0899267577800933 970 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3148 9097893 49.47 µM -1.3420536045827 0.0929531549211191 no 3029 0.0897893077844338 969 17174100 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.3433950726137 0.092729818552032 no 3030 0.0895720407781078 987 6312947 SGTC_1381 2324-0066 62.1 µM -1.34394391989023 0.0926385573558403 no 3031 0.0894832610943508 1006 10885928 SGTC_2996 9066192 71.4286 µM -1.34415199898573 0.0926039757650407 no 3032 0.089449620036397 990 6472854 SGTC_2874 9043904 71.43 µM -1.34843150738519 0.0918948615689409 no 3033 0.0887598179214702 985 4463428 SGTC_1051 3253-3903 78 µM -1.3499140578848 0.0916501433796662 no 3034 0.0885217759194153 986 5509239 SGTC_2695 st077686 51.995 µM -1.35401129196019 0.0909763423826415 no 3035 0.0878663875974635 996 2876092 SGTC_978 1416-0512 87.4 µM -1.35533363746984 0.090759665453946 no 3036 0.0876556412797726 1020 6814003 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.36329841588069 0.0894626670155188 no 3037 0.0863942405421772 1011 803109 SGTC_3082 9117008 49.47 µM -1.36422984006897 0.0893118971813864 no 3038 0.0862476196926993 994 41448529 SGTC_1167 k781-0610 148 µM -1.36506729688819 0.0891764993270942 no 3039 0.0861159497525925 987 4525169 SGTC_2207 7258803 200 µM -1.36507597487809 0.0891750970921533 no 3040 0.0861145861350787 1003 3666799 SGTC_56 0957-0365 83.25 µM -1.3661465514683 0.0890022335765598 no 3041 0.0859464847804718 1003 6752360 SGTC_2313 7726885 200 µM -1.36825303004602 0.0886628338030123 no 3042 0.085616443775135 993 726423 SGTC_2 0422-0095 29 µM -1.3707363858583 0.0882639500710206 no 3043 0.0852285739082255 978 6790840 SGTC_3332 9141069 11.198 µM -1.37534276864234 0.0875276035786866 no 3044 0.0845126015276866 987 17332883 SGTC_2050 5263056 171 µM -1.37699052653735 0.0872653199687386 no 3045 0.0842575883966092 1000 763468 YGL055W OLE1 SGTC_1296 1068-0102 11.9 µM -1.38021580823081 0.0867536314799607 no 3046 0.0837601040545837 1001 767053 SGTC_1468 k284-1086 134 µM -1.380327895004 0.0867358893976016 no 3047 0.0837428549608142 1002 15996457 SGTC_735 3076-0345 636 µM -1.38726124534362 0.0856436817462259 no 3048 0.0826810579733921 1005 2888990 SGTC_2144 5628481 200 µM -1.38889825433095 0.085387313580059 no 3049 0.0824318457236919 991 2818399 SGTC_127 0180-0333 59.125 µM -1.38922394308682 0.0853363768526483 no 3050 0.0823823315833803 939 771601 SGTC_1102 cgs 12066b 26.1 µM -1.39041569668766 0.0851501842554914 no 3051 0.0822013413498161 1004 6438352 A 5-HT1B full agonist. SGTC_183 3914-0051 30.55 µM -1.39651767227471 0.0842016147047707 no 3052 0.0812793313291316 1004 1596232 SGTC_2407 paclitaxel 400 µM -1.39704943702133 0.0841193275801573 no 3053 0.0811993526158994 1018 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_913 3487-1245 167 µM -1.39750904951266 0.0840482541965221 no 3054 0.0811302736310656 985 4016153 SGTC_866 0495-0101 262 µM -1.39776283384356 0.0840090289161673 no 3055 0.0810921492815839 988 635694 SGTC_3217 9129673 49.47 µM -1.39957698972008 0.0837290305393526 no 3056 0.0808200142470559 1015 17248312 SGTC_166 k072-0058 166.424 µM -1.39968174046086 0.0837128846539487 no 3057 0.0808043220447883 994 5846229 SGTC_558 k064-0027 21.3 µM -1.39998010022806 0.0836669094197485 no 3058 0.0807596388176948 1000 5088526 SGTC_432 NS 1619 61.3 µM -1.40451691780612 0.0829701517933499 no 3059 0.0800824887417681 990 4552 A K+/calcium channel activator. SGTC_2032 5185112 25.99 µM -1.412971916997 0.0816833061516159 no 3060 0.0788319907451261 990 5718189 SGTC_1336 1486-0901 104 µM -1.41327258473893 0.0816378233313356 no 3061 0.0787877958171746 1000 5006114 SGTC_2210 7115885 190.385 µM -1.41349201384645 0.0816046417527441 no 3062 0.0787555539472982 1028 2927039 SGTC_2775 cyproheptadine 69.59 µM -1.41933426890128 0.0807249242057893 no 3063 0.0779007929067832 1015 2913 A selective serotonin reuptake inhibitor. SGTC_1557 sumaresinolic acid 42.3 µM -1.42066589853729 0.080525415394389 no 3064 0.0777069554057718 1008 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2993 9054257 71.4286 µM -1.42297579689146 0.0801802231541359 no 3065 0.0773715857973211 996 6470217 YGL055W OLE1 SGTC_3071 9117417 49.47 µM -1.42331783653178 0.080129203812766 no 3066 0.0773220193232821 1001 45595590 YGL055W OLE1 SGTC_1041 0206-0046 107 µM -1.42411244900763 0.0800107725030242 no 3067 0.0772069616356717 1012 50494 SGTC_610 4215-0184 155 µM -1.42482353966368 0.0799049017767403 no 3068 0.0771041080085403 961 5605015 SGTC_849 0386-0493 241 µM -1.42513888983224 0.079857984791325 no 3069 0.0770585284468498 1019 726119 SGTC_346 4513-0042 7.16 µM -1.42552266304244 0.0798009161106054 no 3070 0.07700308689524 983 2827372 SGTC_1334 1486-0610 236 µM -1.42571918081442 0.0797717050408332 no 3071 0.0769747088204724 993 3742339 SGTC_1965 Pectolinarigenin 58.4 µM -1.43087369169327 0.0790084061386555 no 3072 0.0762332091090999 1022 5320438 An anti-inflammatory. SGTC_2820 7989630 71.43 µM -1.43160608297057 0.0789004013000162 no 3073 0.0761282938901256 991 2984098 SGTC_3283 9109332 35.8195 µM -1.43204800299061 0.0788352860252844 no 3074 0.076065041934228 978 17027281 SGTC_2951 9072950 58.06 µM -1.43334387719263 0.078644578510529 no 3075 0.0758797942954556 991 16488155 SGTC_1637 st007924 17.4 µM -1.43796664185435 0.0779671163857652 no 3076 0.0752217596278655 975 683336 SGTC_3076 9116187 49.47 µM -1.44084332278726 0.0775477820150673 no 3077 0.0748144755428578 1001 27241210 SGTC_3114 9122766 49.47 µM -1.44152304245501 0.0774489497254562 no 3078 0.0747184861720626 982 17176985 SGTC_2923 7992654 58.14 µM -1.44744461599169 0.0765919866851634 no 3079 0.0738862187744954 996 2985126 SGTC_899 1083-0020 478 µM -1.45013096385273 0.076205607859936 no 3080 0.0735110009792199 1028 767123 SGTC_545 4218-0007 221 µM -1.45174798473983 0.0759737471940955 no 3081 0.0732858458371603 1017 2840508 SGTC_2360 9040895 200 µM -1.45267954792557 0.0758404167055328 no 3082 0.0731563740347643 1009 4914414 SGTC_500 h-89 112 µM -1.45279363434465 0.0758241002806634 no 3083 0.0731405299553955 1030 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3094 9117742 49.47 µM -1.45295448805033 0.075801099828753 no 3084 0.0731181953957073 1017 17149698 SGTC_57 miconazole 162.5 nM -1.45333640803007 0.0757465104244231 no 3085 0.0730651866593694 987 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_268 camptothecin 39.6153 µM -1.45738219083463 0.0751700674046218 no 3086 0.072505455151302 1038 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1460 k062-0059 9.15 µM -1.45800787190495 0.0750812198186957 no 3087 0.0724191866231635 1002 1373085 SGTC_3201 9113999 49.47 µM -1.45929163537552 0.0748991743665946 no 3088 0.0722424283259894 1005 16649224 SGTC_3216 9129716 49.47 µM -1.46157113972219 0.0745767568401642 no 3089 0.0719293839052704 991 8056934 SGTC_602 3130-1533 38.1 µM -1.46591489772472 0.0739653014095245 no 3090 0.0713357364080273 1018 720941 SGTC_1812 st052057 4.327 µM -1.46629215644352 0.0739123773598427 no 3091 0.0712843556930848 1022 3645418 SGTC_394 menadione 8.33 µM -1.46909144066175 0.0735205810336345 no 3092 0.0709039945176514 1014 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2027 5150920 200 µM -1.46973513127615 0.0734307131209042 no 3093 0.070816751984058 979 786715 SGTC_2095 5432005 200 µM -1.47475728593054 0.0727324348421441 no 3094 0.070138904319606 1022 783734 SGTC_1769 st044406 64.4 µM -1.47604725125587 0.0725539019501831 no 3095 0.0699656039657285 1032 670903 SGTC_2109 5483026 200 µM -1.47920018068581 0.0721189454216049 no 3096 0.0695434106465858 1012 759335 SGTC_1068 loratadine 26.9 µM -1.48339047904842 0.071543977551894 no 3097 0.0689853477733947 1034 3957 A H1 histamine antagonist. SGTC_3186 9110464 49.47 µM -1.49591898825048 0.0698458627105953 no 3098 0.0673373837341533 1021 17018021 SGTC_3025 9087895 49.47 µM -1.49920588265526 0.0694055344160948 no 3099 0.0669101147090536 1020 17173641 SGTC_289 k017-0060 526 µM -1.50035888592046 0.0692515800851202 no 3100 0.0667607317373865 1035 5512909 SGTC_1930 st074634 34.3 µM -1.50282925833522 0.0689226103835339 no 3101 0.0664415394826735 1011 684253 YOR116C RPO31 SGTC_1504 k297-0033 30 µM -1.50452884496134 0.0686969835556747 no 3102 0.066222625996216 976 4388117 SGTC_3000 9075062 71.4286 µM -1.50891915297856 0.0681167889340926 no 3103 0.065659722305322 982 17057871 SGTC_2122 5258151 111.688 µM -1.50940653347888 0.0680526138587795 no 3104 0.0655974622303876 1032 2173356 SGTC_174 3553-0389 74.3 µM -1.51504902456488 0.0673130418380617 no 3105 0.0648799947128119 1032 738071 SGTC_861 0443-0273 110 µM -1.51532422999184 0.0672771296806446 no 3106 0.064845157573508 1014 6149169 SGTC_1161 k007-0610 110 µM -1.51844165401409 0.0668713637070754 no 3107 0.0644515488337511 998 5843850 SGTC_1697 st025554 27.742 µM -1.52173499696376 0.0664447593024454 no 3108 0.0640377474031726 1024 1269519 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.52761257221114 0.0656886449378766 no 3109 0.0633043792129109 1005 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.53041007167496 0.0653311146814333 no 3110 0.062957628768701 1005 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2720 fluspirilene 36.88 µM -1.53516791343957 0.0647265150290004 no 3111 0.0623712938702734 1023 3396 An atypical antipsychotic. SGTC_390 dec-rvkr-cmk 16.7 µM -1.53751686571764 0.0644296299852748 no 3112 0.0620833940771256 1025 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_748 act1.228 77.9 µM -1.54005509942939 0.0641100120976378 no 3113 0.0617734616139722 1030 4421505 YNR035C ARC35 SGTC_3116 9124943 49.47 µM -1.54747518600556 0.0631827309640097 no 3114 0.0608743517480225 1010 41905195 YPL160W CDC60 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.54832970610442 0.0630766164816327 no 3115 0.0607714679124811 1037 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1276 0871-0068 94.2 µM -1.54975028179423 0.0629005163384504 no 3116 0.0606007322346654 1030 3414906 SGTC_817 1391-0715 46 µM -1.55101377041325 0.0627442113785028 no 3117 0.0604491919846974 1013 1353946 SGTC_1730 st033808 45.1 µM -1.56134542345923 0.0614774255447991 no 3118 0.0592211357589799 1019 1045166 SGTC_184 1494-0393 24.714 µM -1.5660133132048 0.0609116775092703 no 3119 0.0586727502247397 1033 3090647 SGTC_258 haloperidol 50.781 µM -1.56779509977329 0.0606968015704092 no 3120 0.0584644794378172 1032 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_523 1934-0222 13.7 µM -1.5690626721571 0.0605442989348523 no 3121 0.0583166682323443 1038 1361595 SGTC_1072 oxiconazole 14.9 nM -1.57095043764082 0.0603177362363643 no 3122 0.0580970807912768 1009 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_14 0354-0009 295 µM -1.57820437561001 0.0594533139731083 no 3123 0.0572593326784608 1045 1713507 SGTC_3304 9125678 46.087 µM -1.57906298588127 0.0593516428771169 no 3124 0.0571608052981597 1042 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_976 1348-1067 47.6 µM -1.58216768781993 0.0589851413428018 no 3125 0.056805647340096 1041 5310671 YGL099W LSG1 SGTC_2863 9028737 58.44 µM -1.58751163136854 0.0583584643820793 no 3126 0.0561984073741826 1040 6460917 SGTC_1006 4099-6547 255 µM -1.58939211642372 0.0581391904899481 no 3127 0.0559859466712249 1039 3146833 SGTC_2247 cerulenin 830 nM -1.59755677155514 0.0571946494140231 no 3128 0.0550708267600465 1012 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1907 st060210 83.7 µM -1.59785809768715 0.0571600224944475 no 3129 0.0550372806764725 1029 688793 SGTC_1682 st012968 530 nM -1.60907436512552 0.0558828035425558 no 3130 0.053800040915773 1013 24207270 SGTC_452 diindolylmethane 8 µM -1.60916787330216 0.0558722510010832 no 3131 0.0537898196036695 1034 3071 Inhibits expression of several cancer promoting factors. SGTC_167 3672-0051 66.205 µM -1.60918369313063 0.0558704658646144 no 3132 0.0537880905016052 1021 3237971 SGTC_910 3454-3003 490 µM -1.60970470865784 0.0558116987232393 no 3133 0.0537311682681528 1020 820824 SGTC_1129 3453-1384 223 µM -1.61399735813682 0.0553293703987385 no 3134 0.0532639996625764 1043 1084452 SGTC_2185 6113692 200 µM -1.61591397642809 0.0551150821110374 no 3135 0.0530564566900477 1031 874150 SGTC_2119 5528445 120.635 µM -1.61697961807546 0.0549962215380521 no 3136 0.0529413402887723 1049 791935 SGTC_1745 st081495 74 µM -1.62038707111264 0.0546175166203318 no 3137 0.0525745776980972 1010 13842402 YBL026W LSM2 SGTC_2127 5253358 187.912 µM -1.63403990390523 0.0531207819201994 no 3138 0.0511252360342185 1036 20612 SGTC_3247 9135149 49.47 µM -1.63717265879147 0.0527819734614808 no 3139 0.0507971990857521 1022 8934436 YOR116C RPO31 SGTC_2682 pyrogallin 40.03 µM -1.63829095370467 0.0526614455603568 no 3140 0.0506805069410437 1032 822798 An ATP competetive kinase inhibitor. SGTC_779 1360-0071 233 µM -1.64453119651154 0.051992887616008 no 3141 0.0500332628890438 1025 7566 SGTC_1895 st058434 18.3 µM -1.64924499739675 0.0514923523051347 no 3142 0.0495487264230711 1054 5393175 SGTC_1998 st075797 76.8 µM -1.6512786994052 0.05127759018132 no 3143 0.0493408398227367 1031 24208315 SGTC_1911 st060208 74.3 µM -1.66347798755033 0.0500042448631906 no 3144 0.048108396779262 1036 688783 SGTC_1835 st008666 49.2 µM -1.66434934560078 0.0499142671897503 no 3145 0.0480213182671336 1028 690455 SGTC_2589 lobaric acid 100 µM -1.6750343326772 0.0488213883125307 no 3146 0.0469637478351058 1033 73157 A novel microtubule depolymerizer. SGTC_3334 9142812 21.919 µM -1.68017536424764 0.0483024121828083 no 3147 0.0464616005446061 1035 45283678 SGTC_2161 5662504 8.5105 µM -1.68128521184787 0.0481909566839603 no 3148 0.0463537644536815 1003 2859334 SGTC_3157 9099274 49.47 µM -1.68217180981971 0.0481020687626831 no 3149 0.0462677644129962 1025 17217662 SGTC_852 0418-0143 439 µM -1.68675743479956 0.0476444185666222 no 3150 0.0458250015937898 991 5369229 SGTC_2982 9019404 25.97 µM -1.69494681958407 0.0468357897111737 no 3151 0.0450427548189112 1015 22333232 SGTC_467 ro 31-8220 72.8 µM -1.70051824847268 0.0462919801134552 no 3152 0.0445167434345761 1031 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_538 2922-0838 53.3 µM -1.70115575455995 0.0462300797255928 no 3153 0.0444568718464024 1048 777039 SGTC_139 0099-0334 718.624 µM -1.70226320160854 0.0461227071793464 no 3154 0.0443530198598805 1046 97690 SGTC_765 1319-0117 244 µM -1.70258715635395 0.0460913360360803 no 3155 0.0443226776574947 1021 3487746 YGL099W LSG1 SGTC_1674 st016616 23.6 µM -1.70582789144458 0.0457784520348464 no 3156 0.0440200642461511 1027 625830 SGTC_3126 9127922 49.47 µM -1.70646531422463 0.0457171119912169 no 3157 0.0439607394999419 1011 45595682 SGTC_2525 harmine 47.85 µM -1.71054289394726 0.0453262825647691 no 3158 0.043582764314862 1033 5280953 A monoamine oxidase inhibitor SGTC_655 k060-0012 42 µM -1.71388938628565 0.0450075385813318 no 3159 0.0432745213478188 1048 5994525 SGTC_2269 7935389 174.42 µM -1.71804489137866 0.0446142521581241 no 3160 0.0428942137026468 1033 97605 SGTC_1610 st001799 48.1 µM -1.72066997838032 0.0443672378708964 no 3161 0.0426553635564317 1050 621897 SGTC_1822 st052468 42 µM -1.72206670514237 0.0442362591794755 no 3162 0.0425287177969886 1039 2873678 SGTC_575 k072-0246 11.9 µM -1.72332640677594 0.0441183975590736 no 3163 0.0424147575065654 1056 6796779 SGTC_827 3253-0474 693 µM -1.72829644125047 0.0436558534216795 no 3164 0.0419675453867687 1051 5402065 SGTC_338 4055-0136 114 µM -1.73359507848121 0.043167045374354 no 3165 0.0414949771606802 1067 2900563 SGTC_1435 4092-0789 56.7 µM -1.73653505462292 0.042897740400242 no 3166 0.0412346358395923 1043 2248285 SGTC_62 0180-0423 3.232 µM -1.73910927401783 0.0426630554768662 no 3167 0.0410077718423881 1041 30102 YGL099W LSG1 SGTC_2204 7233102 200 µM -1.75149239620869 0.0415485857955081 no 3168 0.0399305649624706 1042 2172480 SGTC_506 n9-isopropylolomoucine 153 µM -1.75355252893115 0.0413654848077975 no 3169 0.0397536056151096 1050 6610355 SGTC_2954 9074818 52.69 µM -1.75870610744393 0.0409103070354324 no 3170 0.0393137197520491 1059 16648742 SGTC_1530 rhein 70.4 µM -1.76678828572667 0.0402046576326758 no 3171 0.0386318456311744 1058 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_442 cape 100 µM -1.77354158290127 0.0396226427761644 no 3172 0.0380695039107323 1067 5281787 SGTC_3193 9111931 49.47 µM -1.77453516746342 0.039537594433943 no 3173 0.0379873351943295 1051 17087244 SGTC_1465 k213-0056 144 µM -1.78145799579926 0.0389491310875274 no 3174 0.0374188305147353 1017 24048857 YMR208W ERG12 SGTC_2888 9058547 12.99 µM -1.78505053848073 0.0386465754824188 no 3175 0.0371265598674996 1042 16476514 SGTC_991 3996-0057 64.7 µM -1.7852300754463 0.0386315056778368 no 3176 0.03711200275603 1048 715343 SGTC_1664 st014217 9.02 µM -1.7905255539558 0.0381891678654424 no 3177 0.0366847314805414 1024 3982782 SGTC_3348 9149464 3.537 µM -1.80543209881865 0.0369661451574946 no 3178 0.0355035460017317 1046 1951442 SGTC_2831 7999036 19.48 µM -1.80879602374228 0.0366946238487949 no 3179 0.0352413491345472 1053 2988270 SGTC_3316 9136639 10.545 µM -1.80975529535396 0.0366174952491666 no 3180 0.0351668716687964 1029 4903665 SGTC_1957 st077035 62.4 µM -1.81078621528216 0.0365347537901886 no 3181 0.0350869754697187 1064 705593 SGTC_3278 9139605 49.47 µM -1.8217084711444 0.0356674966359844 no 3182 0.0342496159634761 1044 7958859 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.82847012840607 0.0351391098476302 no 3183 0.0337395124222078 1044 688664 SGTC_2176 5809774 33.9695 µM -1.83146587569221 0.0349070702873886 no 3184 0.0335155182820527 1027 2870539 SGTC_3179 9107801 49.47 µM -1.83277971912763 0.0348057023397059 no 3185 0.033417668183138 1048 4818259 SGTC_1613 st002381 52.1 µM -1.83550426613541 0.0345962635237996 no 3186 0.0332155037824808 1051 551167 SGTC_2064 5220758 200 µM -1.83706166037854 0.0344770106868824 no 3187 0.0331003966256996 1050 788518 SGTC_2263 7948595 193.29 µM -1.8385578170852 0.0343627652021123 no 3188 0.0329901252616094 1049 2971371 SGTC_290 2043-6722 48.1 µM -1.83893107526656 0.0343343120068795 no 3189 0.0329626622170455 1054 773758 YLR208W SEC13 SGTC_1279 0874-0590 65.2 µM -1.83896319973815 0.0343318640873336 no 3190 0.0329602994904856 1059 3523074 SGTC_2611 pyromycin 23.93 µM -1.83967074437517 0.0342779847787684 no 3191 0.0329082955874894 1059 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_144 4161-2749 112.381 µM -1.84543983818839 0.0338412587439705 no 3192 0.0324867912436203 1047 797501 YMR168C CEP3 SGTC_1849 st056239 19.2 µM -1.8467027568091 0.0337462678349021 no 3193 0.0323951159702367 1047 5393181 SGTC_3131 9127911 49.47 µM -1.84732021251333 0.0336999055809423 no 3194 0.0323503726070628 1039 45595681 SGTC_1254 0550-0035 264 µM -1.84754221729115 0.0336832489549595 no 3195 0.0323342977025788 1056 15121435 SGTC_2110 5483698 200 µM -1.85127254914605 0.0334043806398157 no 3196 0.032065176589337 1049 2848765 YHR062C RPP1 SGTC_1256 0570-0116 285 µM -1.85140823405836 0.0333942731854891 no 3197 0.0320554226989215 1060 410638 SGTC_855 0428-0020 25 µM -1.87124485126515 0.0319434694863839 no 3198 0.0306555753318211 1047 6812414 SGTC_2255 7941087 197.44 µM -1.8743783052572 0.0317191283641642 no 3199 0.0304391507628079 1073 935561 SGTC_997 3996-0078 137 µM -1.87608109577299 0.0315977632215005 no 3200 0.0303220725472908 1048 735687 SGTC_2120 5538279 151.968 µM -1.87712885907331 0.0315232755759569 no 3201 0.030250217457985 1063 2058197 SGTC_3084 9116877 49.47 µM -1.88567800083724 0.0309209075890098 no 3202 0.0296691795817501 1057 27241325 SGTC_1838 st055369 84.5 µM -1.89728705781427 0.0301182205961698 no 3203 0.0288950310872779 1049 676036 SGTC_1614 st002383 48.6 µM -1.89826875992242 0.0300511421258995 no 3204 0.0288303435224441 1064 1947235 SGTC_2105 5350118 200 µM -1.9013737770022 0.0298397952467925 no 3205 0.0286265358872925 1061 2133313 SGTC_2694 st077685 81.9 µM -1.90152214100252 0.0298297276087312 no 3206 0.0286168276181173 1052 2838096 SGTC_256 clotrimazole 625 nM -1.9041070056877 0.0296547763938022 no 3207 0.0284481247508705 1041 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_836 0330-0104 1.35 µM -1.91366674061124 0.0290151275292203 no 3208 0.0278313756701586 1049 46494820 SGTC_948 3448-0295 75.3 µM -1.91714695774628 0.0287851287613775 no 3209 0.027609632220679 1041 678569 SGTC_2964 9083345 53.42 µM -1.9216505841847 0.0284897473556885 no 3210 0.027324869538131 1048 17741579 SGTC_2455 5377712 9.75 µM -1.92524745306509 0.0282556529746273 no 3211 0.0270992040303168 1053 2243908 SGTC_1067 clotrimazole 1.36 µM -1.92611039133314 0.0281997292789228 no 3212 0.0270452956981384 1049 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2684 capsaicin 100 µM -1.93649902839572 0.0275336839849873 no 3213 0.0264033057161131 1051 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3293 9120939 62.045 µM -1.93878930251227 0.0273886259324786 no 3214 0.0262634996243383 1063 934087 SGTC_3265 9137266 49.47 µM -1.93968818568199 0.0273318681931487 no 3215 0.026208798121861 1055 17224265 SGTC_2192 5915882 198.485 µM -1.93974011221938 0.0273285924206389 no 3216 0.0262056410468974 1065 2876149 SGTC_1770 st043884 66.3 µM -1.94053640032722 0.0272783997849778 no 3217 0.0261572674387895 1065 670149 SGTC_3341 9147222 25.867 µM -1.94903782928068 0.0267473040518322 no 3218 0.0256454536195035 1042 1939759 SGTC_277 nystatin 15.5 µM -1.95496626344223 0.0263820799211736 no 3219 0.0252935261889257 1071 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2743 auranofin 4.32 µM -1.95763849535056 0.0262188237148393 no 3220 0.0251362234643075 1060 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1238 0333-0287 48.8 µM -1.96396367777305 0.0258357591163367 no 3221 0.0247671521411311 1056 7226 SGTC_816 0325-0417 81.3 µM -1.96721840753982 0.0256404787547341 no 3222 0.0245790183833375 1051 68101 SGTC_1915 st067105 30.6 µM -1.96973721912912 0.0254902022334247 no 3223 0.0244342475179668 1053 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1258 0671-0043 57.1 µM -1.97349098075382 0.025267615712123 no 3224 0.0242198255688612 1062 4298767 SGTC_2721 ifenprodil 61.44 µM -1.9749256530065 0.025182975308804 no 3225 0.0241382928675518 1053 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_150 3970-0969 77.2 µM -1.97606226904115 0.0251160879322354 no 3226 0.0240738625582104 1056 6615640 SGTC_2940 9060638 45.86 µM -1.97647663074206 0.0250917407149702 no 3227 0.0240504099835052 1051 4027022 SGTC_2718 lomofungin 53.02 µM -1.98543385931376 0.0245702454804449 no 3228 0.0235481109895911 1063 5351222 A RNA synthesis inhibitor. SGTC_2238 6671620 73.2395 µM -1.99503291710994 0.0240215099553695 no 3229 0.0230196449255217 1050 729941 SGTC_3252 9135871 49.47 µM -1.99975034781979 0.0237556318213701 no 3230 0.0227636142761532 1067 17682838 SGTC_3307 9126885 69.2785 µM -1.99980640724699 0.0237524872041218 no 3231 0.0227605862317019 1073 24824909 SGTC_2212 7123476 200 µM -2.00165176285463 0.0236491683875903 no 3232 0.022661098858247 1074 1085715 SGTC_269 exalamide 29 µM -2.00727665569595 0.023336567760332 no 3233 0.0223601066920138 1073 3316 A derivative of salicylamide. SGTC_363 0455-0021 3.06 µM -2.00792960134474 0.0233005069236219 no 3234 0.0223253865405395 1026 4597466 SGTC_3200 9114385 49.47 µM -2.01443305698442 0.0229438876263016 no 3235 0.0219820433114329 1051 17018030 YLR208W SEC13 SGTC_1283 0922-0125 16.4 µM -2.02098535849467 0.022589250616342 no 3236 0.0216406403858616 1052 3360884 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.02299526667629 0.0224813968393371 no 3237 0.0215368177629846 1058 7104 SGTC_1394 3474-0001 65.7 µM -2.02513915191559 0.0223668326700344 no 3238 0.0214265388179009 1074 5017666 YIL048W NEO1 SGTC_517 1365-0151 113 µM -2.03072559651173 0.0220706175334845 no 3239 0.0211414191466034 1063 768657 SGTC_672 1441-0018 53.7 µM -2.04386355967319 0.021387019248543 no 3240 0.0204835139810601 1057 251141 SGTC_1338 1486-1223 76 µM -2.05121840048655 0.0210122068052049 no 3241 0.0201228413819675 1059 3444526 SGTC_3244 9134489 49.47 µM -2.05764168986571 0.0206894291276302 no 3242 0.0198122707890113 1070 16584271 SGTC_2163 5671233 125 µM -2.06036674059849 0.0205537662698429 no 3243 0.0196817469852511 1053 701023 SGTC_2710 st078562 53.7235 µM -2.06423625908906 0.0203624230464078 no 3244 0.0194976606031382 1072 17250908 SGTC_3326 9140064 16.379 µM -2.06714213695701 0.0202197252724178 no 3245 0.0193603813080935 1068 1868434 SGTC_2218 6965428 192.983 µM -2.06948500708114 0.0201052931212436 no 3246 0.019250298409458 1061 675684 SGTC_1369 1866-0067 208 µM -2.0754847354516 0.0198147517219619 no 3247 0.0189708160673442 1048 3531355 SGTC_660 4031-1742 102 µM -2.07917537417026 0.0196378059754607 no 3248 0.0188006171105934 1057 6738706 SGTC_2970 9090938 41.86 µM -2.08435847599374 0.0193915713868492 no 3249 0.0185637859707879 1055 17217104 SGTC_2533 agelasine 13.65 µM -2.0918849321999 0.0190386839580042 no 3250 0.0182244051442037 1067 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2780 5215298 71.43 µM -2.10835277567492 0.0182855759625347 no 3251 0.0175002430308323 1072 2834131 SGTC_2417 cerulenin 830 nM -2.109206877744 0.0182472184324256 no 3252 0.0174633642589312 1065 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3140 9094243 49.47 µM -2.10997257281797 0.0182128895450545 no 3253 0.0174303591897471 1062 19291112 SGTC_489 paxilline 115 µM -2.1125875603129 0.0180960648093758 no 3254 0.0173180421834466 1077 105008 A toxic potassium channel blocker. SGTC_2198 6589944 200 µM -2.11698239392934 0.0179011642055677 no 3255 0.0171306710232825 1057 5290268 SGTC_141 0443-0274 32.331 µM -2.11743946813228 0.0178809971940395 no 3256 0.0171112837626632 948 1627241 SGTC_450 aminopyrene 156 nM -2.1186223071375 0.0178288979523659 no 3257 0.0170611994912984 1063 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1388 3346-4487 254 µM -2.12271742911517 0.0176495235384155 no 3258 0.0168887688030407 1081 3345614 SGTC_512 prima-1 270 µM -2.14312812739226 0.0167782931765026 no 3259 0.0160514057314226 1075 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1718 roemerine 11.9335 µM -2.14340967725696 0.0167665371865234 no 3260 0.0160401083580255 1020 235224 An aporphine alkaloid with mutagenic activity. SGTC_247 mechlorethamine 29.705 µM -2.1477848465707 0.0165847574481526 no 3261 0.0158654256844382 1070 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2887 9044784 58.44 µM -2.14970920405598 0.0165053397948375 no 3262 0.0157891119786327 1059 6465546 SGTC_923 1900-2434 73.3 µM -2.16441100192596 0.0159092762941361 no 3263 0.015216410105841 1064 5910570 SGTC_527 4476-4215 268 µM -2.1695577093079 0.0157050178700028 no 3264 0.0150201840397566 1070 4418754 SGTC_727 3032-0951 202 µM -2.1875352795956 0.0150090972198551 no 3265 0.0143517353349863 1082 3652836 SGTC_3044 9093193 49.47 µM -2.18992746320092 0.0149185231947592 no 3266 0.0142647489394972 1069 25236277 SGTC_3117 9124945 49.47 µM -2.20568937514291 0.0143334070009404 no 3267 0.013702878176319 1078 17592065 SGTC_1260 0700-1617 7.75 µM -2.20641087977401 0.0143071029526019 no 3268 0.0136776219739196 1069 2853078 SGTC_2692 st077426 47.7 µM -2.20741557504343 0.0142705438214256 no 3269 0.0136425196199483 1071 25238571 SGTC_2362 9071156 126 µM -2.21763034310396 0.0139033911479072 no 3270 0.0132900236178864 1081 653133 SGTC_911 3456-4043 236 µM -2.21829296995535 0.013879858025398 no 3271 0.0132674316012678 1076 914281 SGTC_542 3381-0244 89.3 µM -2.22422497339218 0.0136707093117348 no 3272 0.0130666558122791 1077 1112843 SGTC_263 alizarin 107.927 µM -2.23556284577851 0.0132785194059605 no 3273 0.0126902103211632 1066 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2983 9022671 12.99 µM -2.23687063338529 0.0132339129070245 no 3274 0.0126473982012776 1077 6405161 SGTC_1377 2944-0135 198 µM -2.243379737076 0.0130138186460315 no 3275 0.0124361687094779 1062 1894137 SGTC_1406 3909-7906 11.9 µM -2.2523388117035 0.0127160621688954 no 3276 0.0121504346304325 1037 X1406 SGTC_502 l-744,832 89.3 µM -2.25539094655573 0.0126159790379222 no 3277 0.0120544002573802 1081 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1364 1653-0028 37.6 µM -2.26397645441933 0.012338098203771 no 3278 0.0117877814918788 1071 5718652 SGTC_3149 9097855 49.47 µM -2.26940141015247 0.0121652595782888 no 3279 0.0116219632596923 1070 25236625 YMR079W SEC14 SGTC_1806 st050005 60.3 µM -2.27680220021394 0.0119328575863207 no 3280 0.0113990200427126 1079 5194765 SGTC_731 3966-0296 387 µM -2.29072952689414 0.0115059347847294 no 3281 0.0109895308896843 1082 660956 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.29608001564873 0.0113454854958329 no 3282 0.0108356533610944 1078 4174840 SGTC_1866 st057638 64 µM -2.31690538004764 0.0107393492064538 no 3283 0.0102544433190345 1063 688802 SGTC_491 tetrandrine 80.3 µM -2.32165713834231 0.0106050641533107 no 3284 0.0101257022973249 1083 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.32174405863193 0.0106026214631869 no 3285 0.0101233605295087 1077 229346 A bile salt which induces apoptosis. SGTC_2116 5511452 16.8835 µM -2.32205772396766 0.0105938107123068 no 3286 0.0101149138262525 1084 870744 SGTC_3253 9135987 49.47 µM -2.32605063981178 0.0104822072409519 no 3287 0.0100079246683443 1075 4182430 SGTC_3125 9127534 49.47 µM -2.32694247418384 0.0104574205799733 no 3288 0.00998416358872561 1071 1639235 SGTC_1303 1160-0052 261 µM -2.33567776183479 0.0102173296239397 no 3289 0.00975402117969881 1080 3562476 SGTC_3303 9125618 40.5795 µM -2.33811189543977 0.0101512894814018 no 3290 0.00969072214931594 1069 22695467 SGTC_2476 5806916 10.51 µM -2.33941130487277 0.0101161880752674 no 3291 0.00965707850950987 1065 2870194 SGTC_315 k915-0449 187 µM -2.35169483600058 0.00978956715271382 no 3292 0.00934404981067216 1068 20970215 YNL149C PGA2 SGTC_1171 0368-0077 21.4 µM -2.35672378755862 0.00965852740430248 no 3293 0.00921847743196876 1076 3239779 SGTC_1319 1306-0155 43.7 µM -2.36160704026037 0.00953275362755698 no 3294 0.00909795907369564 1082 3122360 SGTC_2657 nystatin 74.44 µM -2.36402493655099 0.00947100966356091 no 3295 0.00903879786756044 1069 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2004 4023728 41.89 µM -2.37046332904181 0.0093082997908046 no 3296 0.00888290310180522 1066 360084 YDR527W RBA50 SGTC_3240 9133527 49.47 µM -2.40595418204663 0.00845456298655349 no 3297 0.008065143796549 1088 17617455 SGTC_2369 9071472 200 µM -2.40775681011416 0.00841309656158053 no 3298 0.0080254344597932 1085 17296037 SGTC_2416 tofa 880 nM -2.41903466565413 0.0081576980845732 no 3299 0.0077808785541602 1070 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1418 3966-3099 2.4 µM -2.44096042800155 0.00768059862090196 no 3300 0.00732412989502071 1082 740335 SGTC_2345 9052315 157.45 µM -2.44355463771292 0.00762580697196345 no 3301 0.00727168362921802 1070 6469265 SGTC_286 k060-0067 22.9 µM -2.44764820503218 0.0075400476458008 no 3302 0.00718959874685958 1083 5985051 SGTC_344 k064-0035 6.43 µM -2.5206125435001 0.00614770420846363 no 3303 0.00585753843102681 1055 5088750 SGTC_3033 9090887 49.47 µM -2.52285887032084 0.00610871508670643 no 3304 0.00582025538314867 1069 19325384 SGTC_423 5-fluorouracil 457 µM -2.52977373487183 0.00599006671334816 no 3305 0.00570680520112113 1067 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3062 9077494 49.47 µM -2.54389616271471 0.00575407655437862 no 3306 0.0054811833671023 947 16459633 SGTC_518 1021-0119 62.6 µM -2.54851946191619 0.00567863270503759 no 3307 0.00540906252457557 1086 1097762 SGTC_2658 polymyxin b sulfate 77.05 µM -2.5523965036679 0.00561604477636708 no 3308 0.0053492344718416 1088 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_609 0986-0026 86.3 µM -2.55351722745364 0.00559806718938446 no 3309 0.00533205015133367 1076 2848610 SGTC_2113 5491891 107.031 µM -2.55470443579517 0.00557907888548291 no 3310 0.00531389996876259 1088 789979 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.56351039760865 0.00544001244465154 no 3311 0.00518097986015535 1088 688662 SGTC_1479 0549-0158 134 µM -2.5652993246983 0.00541214063133283 no 3312 0.00515434163041544 1088 5440202 SGTC_1597 7-benzyloxygramine 47.5 µM -2.56791229913228 0.0053716581138155 no 3313 0.00511565187524261 1065 260807 SGTC_3050 9093513 49.47 µM -2.57516848644258 0.00526064714411511 no 3314 0.00500956338170541 1074 25236664 SGTC_668 1682-0499 62.6 µM -2.65526020826627 0.00416429641749812 no 3315 0.00396236265650577 1085 682214 SGTC_824 1304-0008 100 µM -2.73671144962164 0.00326356435511755 no 3316 0.00310283495022786 1086 768245 SGTC_728 3030-5151 22.5 µM -2.78568447190157 0.0028104094745021 no 3317 0.00267074186838764 1094 3125388 SGTC_2539 epi(13)torulosol 80 µM -2.80231484012646 0.00266995521536859 no 3318 0.0025368665944415 1073 6708597 SGTC_2911 7942208 15.64 µM -2.81749029736746 0.00254735366398263 no 3319 0.00242002885196401 1078 1243384 SGTC_2008 4012253 172 µM -2.81805396765031 0.00254289943458803 no 3320 0.00241578440666775 1079 603940 SGTC_1128 3448-9350 235 µM -2.82248983978705 0.00250809130694133 no 3321 0.0023826165946954 1079 619386 SGTC_440 fluspirilene 35.1 µM -2.82460319721455 0.00249165987044778 no 3322 0.0023669600588927 1086 3396 An atypical antipsychotic. SGTC_2101 5377231 179.231 µM -2.82734695735264 0.00247047227577684 no 3323 0.00234677221448552 1093 2844213 SGTC_601 0986-0029 62.9 µM -2.82788760691328 0.00246631659288924 no 3324 0.00234281269327462 1083 24747981 SGTC_2725 haloperidol 53.21 µM -2.85696879718562 0.00225188818741772 no 3325 0.00213853940865555 1088 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.85968643807807 0.00223273897774755 no 3326 0.00212030036134713 1075 5379071 SGTC_519 k048-0011 62.8 µM -2.86230925734017 0.00221439794803098 no 3327 0.00210283159936101 1084 6836379 SGTC_528 3492-0019 172 µM -2.87491509628806 0.00212813784572457 no 3328 0.00202068078041459 1086 2869262 SGTC_3260 9137109 49.47 µM -2.88956237374173 0.00203174352829643 no 3329 0.00192889232954187 1086 17478346 SGTC_1261 0712-0010 12.7 µM -2.8907002957387 0.00202442331386971 no 3330 0.00192192249583654 1084 2840123 SGTC_1275 0867-0008 21.1 µM -2.89212851937479 0.002015269482242 no 3331 0.00191320693358042 1093 3422836 SGTC_951 1171-0579 82.7 µM -2.91388986075661 0.00188036656598493 no 3332 0.00178477909509176 1077 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2924 9010168 62.78 µM -2.938888241296 0.00173556114005565 no 3333 0.00164695912291665 1085 2993929 SGTC_2730 imipramine 71.33 µM -2.94253791791331 0.00171529072622023 no 3334 0.00162766958546957 1087 3696 A tricyclic antidepressant. SGTC_3264 9137442 49.47 µM -2.96348706641493 0.00160305004903382 no 3335 0.00152087422072867 1084 17015726 SGTC_1107 amlodipine 47 µM -3.06187675419929 0.00116020459700091 no 3336 0.00109976997864011 1011 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_151 3013-0144 2.285 µM -3.08139497581894 0.00108695984267137 no 3337 0.0010301657265839 1085 906558 YHR107C CDC12 SGTC_2174 5790901 200 µM -3.20127417513674 0.000722556180283757 yes 3338 0.000684106377409251 1094 786020 SGTC_2679 rapamycin 1 nM -3.23629856017101 0.000639667156637046 yes 3339 0.000605453295893892 1062 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2087 5276107 200 µM -3.24933062663907 0.000611134020341384 yes 3340 0.000578384711425784 1093 144405 SGTC_157 1348-1695 65.819 µM -3.27239635801859 0.000563496142160639 yes 3341 0.000533199812036 1083 5380510 SGTC_1286 0929-0070 131 µM -3.33413440723552 0.000452358489314713 yes 3342 0.000427826501924904 1091 1420408 SGTC_3275 9138069 49.47 µM -3.36266293941906 0.000408196172974262 yes 3343 0.000385972773547836 1093 17617007 SGTC_2097 5376186 200 µM -3.45887697027192 0.000287043487955036 yes 3344 0.000271216307762709 1094 742755 SGTC_778 3456-2434 196 µM -3.52978483418964 0.000220199298707982 yes 3345 0.000207948876878078 1020 5539063 SGTC_1961 st076550 68.7 µM -3.5656576429943 0.000192212887067912 yes 3346 0.000181472458202741 1092 1579337 SGTC_541 4513-1321 94 µM -3.58570587461814 0.000178057304124865 yes 3347 0.000168083838920365 1093 747515 SGTC_2729 fluphenazine 10.66 µM -3.65520147257122 0.000136180237798388 yes 3348 0.000128490042603478 1094 3372 An atypical antipsychotic. SGTC_3127 9126946 49.47 µM -3.76364159959633 8.88040733708772e-05 yes 3349 8.37284177013454e-05 1092 27243249 SGTC_55 0767-0285 6.563 µM -3.86521989042345 5.88966976383872e-05 yes 3350 5.5494580529579e-05 1091 3116166 SGTC_1313 1220-0047 237 µM -4.15751535255645 1.71010652558198e-05 yes 3351 1.60863830229903e-05 1091 3528706 SGTC_369 0957-0393 4.5 µM -4.72800346515786 1.20813022475003e-06 yes 3352 1.13369158310108e-06 1095 6997992 SGTC_3263 9137018 49.47 µM -4.81114574521652 7.99813600810842e-07 yes 3353 7.50337663453945e-07 1093 43844957