SGTCid condition conc unit YGR259C|YGR259C.score YGR259C|YGR259C.strain.pval YGR259C|YGR259C.strain.significant YGR259C|YGR259C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1642 st009582 77.7 µM 7.95073321876189 1.60019237380456e-17 yes 1 9.27054191553632e-16 1 6739311 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 6.72322604834523 4.86689140758923e-13 yes 2 8.88722528289052e-12 6 16725076 SGTC_2792 7535235 81.82 µM 6.27493706302587 1.3906646264772e-11 yes 3 1.7488787498321e-10 9 1281891 SGTC_103 0844-0104 51.839 µM 5.12775194514007 2.68962656096187e-08 yes 4 1.46611216683464e-07 97 5375804 SGTC_2799 7812892 81.82 µM 4.82626973657296 1.54533152800362e-07 yes 5 6.9557032778434e-07 18 20205235 SGTC_533 1222-0222 6.71 µM 4.71045733410596 2.94592176786483e-07 yes 6 1.23580769903689e-06 15 3982874 SGTC_1055 3448-0672 86 µM 4.57890275493938 6.02262158099576e-07 yes 7 2.33710715729356e-06 17 748378 SGTC_2381 9035592 200 µM 4.14877980297857 5.47048374242258e-06 yes 8 1.67126064031725e-05 15 4749657 SGTC_3278 9139605 49.47 µM 4.06226118500434 8.32205709959086e-06 yes 9 2.42998283342258e-05 13 7958859 SGTC_1107 amlodipine 47 µM 3.81385137325383 2.65355271362851e-05 yes 10 6.84088843556743e-05 39 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_550 4123-0385 25.7 µM 3.80465559914118 2.76639899359417e-05 yes 11 7.10008132100782e-05 30 5731123 SGTC_215 1287-0124 461.5 µM 3.79986470458569 2.82697722142821e-05 yes 12 7.23875531607055e-05 1 5560863 SGTC_1671 st016596 74.5 µM 3.7642851386872 3.31780573777258e-05 yes 13 8.35131053817514e-05 18 2829167 SGTC_553 k007-0256 45.7 µM 3.75471003987176 3.46306970218136e-05 yes 14 8.67711320997361e-05 24 6287000 SGTC_137 0438-0332 85.389 µM 3.70033677063947 4.40888799527295e-05 yes 15 0.000107656769045754 139 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2651 TUB2.036 5 µM 3.523994838711 9.4393072454249e-05 yes 16 0.000212546264691245 194 15992207 YFL037W TUB2 SGTC_3267 9137951 49.47 µM 3.52291650417982 9.48237765632888e-05 yes 17 0.000213412901855572 14 16643986 SGTC_524 r073-0010 27.8 µM 3.51388952852457 9.85024384537537e-05 yes 18 0.000220798211745933 67 2772106 SGTC_1349 flufenamic acid 69 µM 3.39063866273831 0.000164190889312708 yes 19 0.000348649850207639 32 3371 A non-steroidal anti-inflammatory. SGTC_3185 9108267 49.47 µM 3.35450001780863 0.000190141411223107 yes 20 0.000397542740190488 40 4910486 SGTC_2557 derrustone 83.84 µM 3.30585291503598 0.000231156734850059 yes 21 0.000473438891108056 62 629853 An antioxidant. SGTC_2724 maprotiline 69.64 µM 3.29407366275802 0.000242260283795729 yes 22 0.000493733083752869 33 4011 A tricyclic antidepressant. SGTC_433 pimozide 108 µM 3.29340102941588 0.000242909108777473 yes 23 0.000494915912922321 36 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2944 9067346 25.62 µM 3.22749688310076 0.000314948941024881 yes 24 0.000624392007708084 58 6473075 SGTC_1921 5740136 50 µM 3.20053960692026 0.000349783958308266 yes 25 0.000685852577548562 91 1774243 SGTC_2712 st079126 47.7 µM 3.13905358663283 0.000443058837868461 yes 26 0.000847472247480745 46 3152970 SGTC_3149 9097855 49.47 µM 3.13822265026416 0.000444464278373648 yes 27 0.000849878547538532 61 25236625 YMR079W SEC14 SGTC_931 2812-0076 566 µM 3.13769949787132 0.000445351253851057 yes 28 0.000851396761350614 57 3450959 SGTC_3063 1327-0034 4 µM 3.13423865293933 0.000451260375653484 yes 29 0.000861503302905811 66 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2814 7977482 42.97 µM 3.13116594264384 0.000456567603484628 yes 30 0.00087056873377685 92 6456762 SGTC_1704 st028805 70.8 µM 3.11505986333992 0.00048534495157534 yes 31 0.000919537910513064 33 2876101 SGTC_3142 9086498 49.47 µM 3.11471561912182 0.000485977970676001 yes 32 0.000920611652821861 73 25236367 SGTC_924 2046-0044 21.3 µM 3.09079368431164 0.000531887332589104 yes 33 0.000998111427932223 40 3623589 SGTC_414 piperonyl butoxide 100 µM 3.03684511539903 0.000650525363183755 yes 34 0.0011953413112862 37 5794 A potent inhibitor of cytochrome P450. SGTC_2993 9054257 71.4286 µM 3.01310554744332 0.000710100519340717 yes 35 0.00129294481915496 101 6470217 YGL055W OLE1 SGTC_11 0438-0307 1.3 µM 2.98029742937623 0.000800731880390136 yes 36 0.00143984314476352 45 4011476 SGTC_2205 7238770 200 µM 2.96552193039463 0.000844928715254846 yes 37 0.00151084900386583 27 279867 SGTC_3197 9113331 49.47 µM 2.95088621143127 0.000890909680336953 yes 38 0.00158431813294652 102 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3331 9141060 1.957 µM 2.94681746416483 0.0009040949868243 yes 39 0.00160531332850481 73 4906567 YPR165W RHO1 SGTC_1297 1068-0111 14.1 µM 2.94419831145236 0.000912677324393936 yes 40 0.00161896226293054 44 767057 SGTC_2780 5215298 71.43 µM 2.92719938174522 0.00097022326088908 yes 41 0.00171014768086298 99 2834131 SGTC_1675 st018485 24.5 µM 2.91509581363231 0.00101320740464118 no 42 0.00177789679457461 82 3323024 SGTC_2838 9002687 71.43 µM 2.88656755057028 0.00112152258598405 no 43 0.00194734566365471 78 6457060 SGTC_2553 4-methylesculetin 85.09 µM 2.87445637164202 0.00117063511993027 no 44 0.0020236184089237 80 5319502 SGTC_1175 0741-0056 27.6 µM 2.85872861024697 0.00123735230285697 no 45 0.00212671251984096 75 765927 SGTC_960 1222-0186 7.7 µM 2.8263726189246 0.00138567117305054 no 46 0.00235392321527728 88 3126296 SGTC_273 hydroxyurea 18.1 mM 2.76302469353113 0.00172400856842721 no 47 0.00286342168240336 96 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 2.71770591608321 0.00201045893772804 no 48 0.003286811850437 66 17037758 SGTC_1079 idarubicin 2.36 µM 2.71163707825437 0.00205193654306321 no 49 0.00334759259131285 74 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1227 3909-8010 46.6 µM 2.70563265097502 0.0020937366839667 no 50 0.00340872070749279 94 15982272 SGTC_2760 etidronate 98.04 µM 2.66693819248157 0.00238215467825596 no 51 0.00382728738321041 98 3305 A chelator and antioxidant. SGTC_1064 honokiol 6.76 µM 2.6389436020446 0.00261274055076401 no 52 0.00415824075294737 102 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2399 5884133 200 µM 2.63753431061952 0.00262486471828698 no 53 0.00417555884756129 175 722445 SGTC_2282 7944268 200 µM 2.63534987731931 0.00264375791730256 no 54 0.00420252981229801 128 2970414 SGTC_954 1189-0853 2.85 µM 2.626919265564 0.00271783166064599 no 55 0.00430808870878992 127 2828194 SGTC_2385 9074692 200 µM 2.60804344827593 0.00289051650552802 no 56 0.00455306976234212 121 17046906 SGTC_3346 9158254 43.5805 µM 2.58238573294784 0.00314110281649169 no 57 0.00490599243768094 109 17639500 SGTC_857 0438-0306 1.35 µM 2.57801351756839 0.0031857029379767 no 58 0.00496850553121549 74 4686136 SGTC_203 k066-0004 30.888 µM 2.57739931267341 0.0031920137652207 no 59 0.00497734392314699 113 6795412 SGTC_1279 0874-0590 65.2 µM 2.57702619435217 0.00319585296865239 no 60 0.00498271992149289 109 3523074 SGTC_1319 1306-0155 43.7 µM 2.55781557578837 0.00339922355324377 no 61 0.0052665968804427 144 3122360 SGTC_2558 carylophyllene oxide 100 µM 2.54156222460841 0.00358028963690682 no 62 0.00551791502974217 103 6708694 An oxygenated terpenoid and antifungal agent. SGTC_142 0335-0849 62.6745 µM 2.53412941952067 0.00366594128274544 no 63 0.00563635448268286 259 3889043 YPR107C YTH1 SGTC_230 MPP+ 141.667 µM 2.51873207014984 0.00384924464405978 no 64 0.00588891203163029 113 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1657 st012939 43.4 µM 2.49333991198859 0.0041695320273369 no 65 0.00632738176591481 82 24207257 SGTC_1713 st033146 12.748 µM 2.49201287582714 0.00418690813858823 no 66 0.00635107163119683 146 674619 SGTC_2852 9023854 51.95 µM 2.48857039434045 0.00423228606864675 no 67 0.00641289217134149 118 19798528 SGTC_3329 9141233 27.5565 µM 2.477680313897 0.00437874669160244 no 68 0.00661197855794504 99 4909101 YNL103W MET4 SGTC_1640 st009078 66.4 µM 2.45664720973448 0.00467449829292327 no 69 0.00701201657283298 93 690618 SGTC_881 0833-0569 170 µM 2.45029711185868 0.00476722572154813 no 70 0.00713691896676364 136 5418700 SGTC_2921 7974240 10.71 µM 2.44461416109969 0.00485159826234239 no 71 0.00725035901773025 168 2979074 YDR527W RBA50 SGTC_1447 4239-0816 81.9 µM 2.43913209761717 0.00493424697802618 no 72 0.00736129267586824 136 1341554 SGTC_1653 st012112 65 µM 2.43472904497442 0.00500153425587329 no 73 0.0074514723007463 90 720429 SGTC_2036 5160441 105 µM 2.42910018964866 0.00508874380349066 no 74 0.00756817445337445 189 134534 YIL048W NEO1 SGTC_527 4476-4215 268 µM 2.42783461829168 0.0051085371104284 no 75 0.00759463391448667 159 4418754 SGTC_3347 9188721 44.724 µM 2.42507301394393 0.00515196622173668 no 76 0.00765265410337827 108 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1374 2889-5571 141 µM 2.41602438474863 0.00529657666270863 no 77 0.0078455052433485 174 2853281 SGTC_251 melphalan 456.522 µM 2.41547863382782 0.00530541289527642 no 78 0.00785727221426864 157 460612 A DNA alkylator. SGTC_1005 4092-0690 4.4 µM 2.41546858930011 0.00530557564864093 no 79 0.00785748893039866 132 1529343 SGTC_1995 st072814 61.1 µM 2.41509889864383 0.00531156890566763 no 80 0.00786546886570319 118 5769371 SGTC_1506 4226-2149 212 µM 2.41264941147278 0.00535143120938561 no 81 0.00791852244955805 156 991114 SGTC_424 splitomicin 100 mM 2.36909651509745 0.00610599716103078 no 82 0.00891579976101898 141 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2591 skatole 100 µM 2.33325227249163 0.00679621962356031 no 83 0.0098174543980738 146 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.32915514834082 0.00687934695643593 no 84 0.00992542400591631 184 23665772 A membrane-active detergent. SGTC_537 1334-0398 209 µM 2.32220649266994 0.00702238372834946 no 85 0.0101109097797608 156 5846986 SGTC_133 0724-0033 378.92 µM 2.30569047990141 0.00737294482362511 no 86 0.0105639667219272 128 280309 SGTC_1078 idebenone 36.1 µM 2.30242046990167 0.00744415364202041 no 87 0.0106557358451471 218 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2850 9015429 58.44 µM 2.2936193233311 0.00763882914123538 no 88 0.0109061872338918 149 6457570 SGTC_1025 k007-0731 70 µM 2.2866370114435 0.00779644769598993 no 89 0.0111085095266485 136 6256118 SGTC_266 formosanin C 406 nM 2.28108415635531 0.00792383341486489 no 90 0.0112717337411625 210 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_478 N-arachidonylglycine 10 µM 2.2804068238746 0.00793949639178965 no 91 0.0112917856391705 62 5283389 SGTC_3136 9095672 49.47 µM 2.27435790572622 0.00808058621538684 no 92 0.0114722380963821 145 17217380 SGTC_1496 4469-0713 57.4 µM 2.26947465832085 0.00819608981581391 no 93 0.0116197382968515 123 746691 SGTC_94 0334-0113 514.748 µM 2.2661875691307 0.00827465389134368 no 94 0.0117199507094634 160 6795178 SGTC_101 0490-5701 117.494 µM 2.25966962122591 0.00843239627416715 no 95 0.0119208815385037 116 4661669 SGTC_2405 ticlatone 3.52 µM 2.25662328650633 0.00850702213669528 no 96 0.0120158120118321 227 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2791 5663188 71.43 µM 2.24104401089192 0.0088977967796445 no 97 0.0125116121663263 161 54690634 SGTC_1929 genistein trimethyl ether 50.5 µM 2.23355033652847 0.00909130015657655 no 98 0.0127563373893574 144 136420 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 2.2238223916493 0.00934798760824953 no 99 0.0130801981240238 134 364106 SGTC_3339 9145883 14.936 µM 2.19942117395334 0.0100199337941445 no 100 0.0139239942101686 147 2030670 SGTC_1808 st050063 61.5 µM 2.19485844489549 0.0101501538873076 no 101 0.0140868767484273 145 4011993 SGTC_2877 9040724 71.43 µM 2.18500843615612 0.0104363162741793 no 102 0.0144441140231506 141 6463895 SGTC_2369 9071472 200 µM 2.18301380884416 0.0104951127536155 no 103 0.0145173965572606 175 17296037 SGTC_2676 harmalol 100 µM 2.17933319625121 0.0106043657866259 no 104 0.0146534624326627 149 5459187 A monoamine oxidase inhibitor SGTC_3314 9135860 59.4275 µM 2.16001767708745 0.011194104776672 no 105 0.0153856505725069 155 25252478 SGTC_3340 9146634 11.102 µM 2.13747297696022 0.0119183170602553 no 106 0.0162797706801055 173 4907387 SGTC_492 tmb-8 126 µM 2.13223666341061 0.0120922276384912 no 107 0.0164936979267407 68 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2342 7990637 118.86 µM 2.13116801786648 0.0121279889936315 no 108 0.0165376513925875 207 2033102 YER133W GLC7 SGTC_572 0960-0087 17.7 µM 2.12723201333604 0.0122604959988507 no 109 0.0167004052209313 244 6796365 SGTC_2748 diazoxide 86.69 µM 2.12118666164875 0.0124664576600645 no 110 0.016953048644084 128 3019 A potassium channel activatior. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 2.11882564911748 0.012547705823616 no 111 0.017052602132693 77 4000243 SGTC_2119 5528445 120.635 µM 2.11034612457716 0.0128432979500459 no 112 0.0174142766881724 181 791935 SGTC_1194 1488-0194 225 µM 2.09755550673168 0.0133005623315092 no 113 0.0179722144998048 213 1391452 SGTC_3343 9148379 18.9835 µM 2.0941834761713 0.0134234296627716 no 114 0.0181218195755312 159 1955036 SGTC_532 1548-0774 215 µM 2.0929312136303 0.013469307508191 no 115 0.0181776476984066 198 5932993 SGTC_548 1436-0017 110 µM 2.0827413507487 0.0138476811466869 no 116 0.0186374030476841 241 9677137 SGTC_1587 estradiol valerate 56.1 µM 2.07297350085015 0.0142189538898777 no 117 0.0190873728899214 175 13791 A steroid. SGTC_1746 st038117 42 µM 2.07258477064263 0.0142339051448085 no 118 0.0191054697846904 224 2898218 SGTC_464 bw-b 70c 158 µM 2.06663063844647 0.0144646095075192 no 119 0.0193844857589445 240 5353454 SGTC_3081 9117243 49.47 µM 2.06605127831252 0.0144872288325399 no 120 0.0194118189925939 185 45595589 SGTC_1499 4480-0877 67.3 µM 2.0495548478835 0.0151441790475168 no 121 0.020203945188703 125 2861909 SGTC_2878 9043973 25.97 µM 2.04529938182155 0.0153177440679603 no 122 0.0204126758142601 168 6465167 SGTC_2451 5856223 45.7 µM 2.03756746823856 0.0156374745563073 no 123 0.0207966041102605 208 2179896 SGTC_1307 1187-1599 12.2 µM 2.03649131930728 0.015682426344465 no 124 0.0208505219491756 199 1538471 SGTC_158 k038-0087 26.446 µM 2.03584440419786 0.0157095019342839 no 125 0.0208829909826996 357 X158 SGTC_1699 st031318 29.054 µM 2.0298463901012 0.0159624543434763 no 126 0.0211860779143626 194 5340658 SGTC_818 4072-2707 53.5 µM 2.0295722169886 0.0159740999376365 no 127 0.0212000206865722 182 882871 SGTC_1725 st036284 20.55 µM 2.02362946366793 0.0162283160284079 no 128 0.0215041455593823 244 707914 SGTC_2957 9076800 11.52 µM 2.02270153756982 0.0162683215646556 no 129 0.0215519641433698 205 16459615 SGTC_1377 2944-0135 198 µM 2.01095007807868 0.0167823136994602 no 130 0.0221653650145351 252 1894137 SGTC_3235 9132602 49.47 µM 1.99193785001729 0.0176432891865155 no 131 0.0231889387021848 236 4912240 SGTC_2950 9072895 21.46 µM 1.99163734091707 0.0176571949770143 no 132 0.0232054316123621 293 17332245 SGTC_1879 gemcitabine 100 µM 1.991548996859 0.0176612847980791 no 133 0.0232102820975308 210 60750 A nucleoside analog which inhibits DNA replication. SGTC_1668 st014914 51.6 µM 1.98427165943056 0.0180009711509719 no 134 0.0236127818896567 192 2839556 SGTC_1259 0671-0132 43 µM 1.98309809537569 0.018056268234509 no 135 0.0236782366607896 238 X1259 SGTC_545 4218-0007 221 µM 1.96089905243221 0.0191298591825392 no 136 0.0249453999477543 234 2840508 SGTC_838 0109-0203 71.4 µM 1.95863619308418 0.0192422829495704 no 137 0.0250777039068867 210 759422 SGTC_231 b-estradiol 524 µM 1.95567773411895 0.0193901122238211 no 138 0.0252515646411311 165 450 A steroid. SGTC_182 3448-4371 550.524 µM 1.95519092905567 0.019414529279152 no 139 0.0252802694178268 229 3491403 SGTC_2156 5649887 115 µM 1.94489313177523 0.0199371972914747 no 140 0.0258939209226051 260 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_6 0844-0013 19.835 µM 1.94347238716994 0.0200102364375239 no 141 0.0259795542702486 471 1584900 SGTC_2483 5729050 27.16 µM 1.93691294229275 0.0203504013342502 no 142 0.0263779930622449 302 2865180 SGTC_602 3130-1533 38.1 µM 1.92518535096018 0.0209707988338788 no 143 0.0271030870466377 270 720941 SGTC_2132 5317594 122.667 µM 1.92008937393742 0.0212453271107257 no 144 0.0274233056375437 198 794577 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.9167605771249 0.0214262909626776 no 145 0.0276341777212071 261 4174840 SGTC_2219 9098279 200 µM 1.91428332775159 0.0215618062353483 no 146 0.0277919817713099 212 902349 SGTC_513 4245-1575 41.7 µM 1.91335115345515 0.0216129870578717 no 147 0.0278515566006605 404 719745 SGTC_31 0508-1974 57.237 µM 1.91278200292679 0.0216442865870423 no 148 0.0278879830297295 223 6810525 SGTC_1357 1503-1303 39.5 µM 1.90431140913267 0.0221146584505017 no 149 0.0284348196054934 285 292895 SGTC_972 1319-0219 195 µM 1.90109858502117 0.022295309281478 no 150 0.028644550458357 251 23903702 SGTC_1154 4088-0362 150 µM 1.89806020389818 0.0224672953649411 no 151 0.0288440758808853 317 6618304 SGTC_3093 9117344 49.47 µM 1.89607191086498 0.0225804462758301 no 152 0.0289752681380439 234 24824913 SGTC_51 1013-0126 23.419 µM 1.89459117266445 0.022665024760849 no 153 0.029073292584732 240 1627850 SGTC_3050 9093513 49.47 µM 1.89435116745244 0.0226787587683441 no 154 0.0290892067817611 228 25236664 SGTC_1434 4073-0095 163 µM 1.88533968163754 0.023199529594201 no 155 0.0296919959802852 231 24133745 SGTC_534 k292-0788 63.4 µM 1.88304853257104 0.0233335280485004 no 156 0.0298468955631405 281 4146317 SGTC_2497 7-hydroxyflavone 100 µM 1.88149414092305 0.0234248074227072 no 157 0.0299523657743809 248 5281894 SGTC_438 sphingosine 6.67 µM 1.87866704435373 0.0235915947357278 no 158 0.0301449851915365 205 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2397 5161689 200 µM 1.87687042340339 0.023698106341751 no 159 0.030267927723624 283 2259942 SGTC_2726 cimetidine 79.27 µM 1.87632102969953 0.0237307574418254 no 160 0.0303056055232481 172 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_849 0386-0493 241 µM 1.87455818819129 0.0238357806535294 no 161 0.0304267649444246 227 726119 SGTC_1463 k081-0032 34.1 µM 1.87348799351052 0.0238997290650272 no 162 0.0305005145885432 172 977755 SGTC_680 0417-1641 114 µM 1.86732210168429 0.0242709807377325 no 163 0.0309283103839399 233 2835990 SGTC_302 1094-0063 18.9 µM 1.85936345740618 0.0247573236402922 no 164 0.0314878189184082 198 5440289 SGTC_3017 9080681 49.47 µM 1.85836418978212 0.0248189613666358 no 165 0.0315586570081219 237 16451914 SGTC_3130 9127414 49.47 µM 1.85801964474828 0.024840243721982 no 166 0.0315831123257574 227 1494646 SGTC_2751 anetholtrithion 17.25 µM 1.8531940439225 0.0251399302635861 no 167 0.0319272755336985 269 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_922 1866-0035 480 µM 1.85303518887549 0.0251498470084257 no 168 0.0319386575741135 346 3156169 SGTC_1622 st003707 19.4 µM 1.85063194813592 0.0253002730226785 no 169 0.0321112601465061 330 10140899 SGTC_69 0096-0274 206.684 µM 1.84643434748287 0.0255648214288192 no 170 0.0324145819228007 350 6741392 SGTC_1845 st056753 3.01 µM 1.8432253694394 0.0257686218801228 no 171 0.0326480561496705 302 5375839 SGTC_303 1348-1668 34.2 µM 1.84163863239806 0.0258698960232376 no 172 0.0327640130867778 224 5380509 SGTC_432 NS 1619 61.3 µM 1.84150256948366 0.0258785957768084 no 173 0.0327739721968181 261 4552 A K+/calcium channel activator. SGTC_1618 st003135 44.5 µM 1.83695885366608 0.026170526200389 no 174 0.0331079849346949 227 1270615 SGTC_1540 guanosine 70.6 µM 1.83585010028714 0.02624217926426 no 175 0.0331899147088769 225 6802 Guanosine is a purine nucleoside SGTC_714 4296-0578 26.1 µM 1.83485954690699 0.0263063323162501 no 176 0.0332632514448466 138 1589775 SGTC_2807 7945238 51.95 µM 1.82732555735976 0.0267985730834625 no 177 0.0338254173802705 298 17148797 SGTC_1561 5-methoxyflavone 52.9 µM 1.81866557115038 0.0273738593437553 no 178 0.0344812336821543 177 94525 SGTC_1714 st033236 13.627 µM 1.81663682371449 0.0275101086519645 no 179 0.0346363705551851 278 2916566 SGTC_2640 pentamidine 10.38 µM 1.80565443872212 0.0282575282533929 no 180 0.0354861667766614 316 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2200 6600604 21.907 µM 1.80497937193172 0.0283040168877174 no 181 0.035538955024129 319 2904777 SGTC_3282 9108498 15.4605 µM 1.80490729533166 0.0283089842186542 no 182 0.0355445950051002 300 16459645 SGTC_1324 1418-0026 34.4 µM 1.80069853621969 0.0286003015307164 no 183 0.0358752042293154 304 1372513 SGTC_2018 5133068 143 µM 1.7996060093603 0.0286763291782447 no 184 0.0359614357678941 297 785362 SGTC_2818 7996756 12.99 µM 1.79378915747034 0.0290839518133954 no 185 0.0364234140986805 196 2241621 SGTC_845 0330-0138 4.51 µM 1.79270666644139 0.0291603374553629 no 186 0.0365099200065446 269 9039800 SGTC_3289 9119912 71.43 µM 1.7867182075379 0.0295859282559112 no 187 0.0369915223861023 288 17014829 SGTC_1647 st011722 22.4 µM 1.7864090929047 0.0296080357668617 no 188 0.0370165222111489 252 2854783 SGTC_3151 9099821 49.47 µM 1.78127254611384 0.0299774066459863 no 189 0.0374339686029053 266 17174189 SGTC_752 1896-0090 130 µM 1.78034341140567 0.030044627501442 no 190 0.0375098883442995 289 772567 SGTC_2087 5276107 200 µM 1.77819106259841 0.0302008254203121 no 191 0.0376862401556238 282 144405 SGTC_1134 3477-0009 42.5 µM 1.77753285917725 0.0302487260230645 no 192 0.0377403047197351 342 3973534 SGTC_393 acivicin 6.25 µM 1.77461089468409 0.0304621321662862 no 193 0.0379810785472716 250 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_803 4488-1585 147 µM 1.77210539532119 0.0306461136123498 no 194 0.0381885317556997 258 747204 SGTC_2144 5628481 200 µM 1.7696242053192 0.030829215892538 no 195 0.0383948819107881 271 2818399 SGTC_2380 9035439 200 µM 1.76811816122296 0.0309407971663191 no 196 0.038520575953905 333 6462575 SGTC_2243 6634756 200 µM 1.76463186445812 0.0312003760917056 no 197 0.0388128282773157 251 885676 SGTC_596 1155-0152 116 µM 1.76160376157119 0.0314272986554966 no 198 0.0390681339780644 366 280313 SGTC_2037 5169046 200 µM 1.75785195955844 0.0317103453045333 no 199 0.0393863508587749 277 5718022 SGTC_1126 isoteolin 1.0172 µM 1.75502822913525 0.0319247620543356 no 200 0.0396272396529041 308 133323 SGTC_3175 9106517 49.47 µM 1.75122430204995 0.0322155006084094 no 201 0.0399536404681984 265 41468073 SGTC_454 lyso-paf C-16 6.67 µM 1.74828471991578 0.0324416703052939 no 202 0.0402073688936088 296 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2222 6885208 172.143 µM 1.74648682537545 0.0325806437294648 no 203 0.040363197197269 211 609514 SGTC_1086 cerivastatin 2.18 µM 1.73898030732984 0.0331661963979724 no 204 0.0410191134404915 255 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2044 5102272 200 µM 1.73540722452468 0.0334479482872175 no 205 0.0413343506756992 250 592666 SGTC_1974 st069448 26.9 µM 1.72802673156527 0.034036170375674 no 206 0.0419917159713091 275 6323587 YNR016C ACC1 SGTC_690 glyoxal 20.3 µM 1.72730346299638 0.03409426942849 no 207 0.0420565887942794 378 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2709 st078560 56 µM 1.72093399750361 0.0346094478052175 no 208 0.0426314007410712 289 17250903 SGTC_1028 k015-0029 4.8 µM 1.71677468830569 0.0349493014059368 no 209 0.0430101737220498 365 4588309 SGTC_648 0375-0473 33.3 µM 1.71207700354255 0.0353364342345876 no 210 0.0434412393390399 350 1713139 SGTC_1939 st074455 53.6 µM 1.70390264474111 0.0360184581859842 no 211 0.0441996384233876 341 1644229 SGTC_2801 7907800 81.82 µM 1.70346083788962 0.0360556251396652 no 212 0.0442409304137593 334 6620925 SGTC_2741 miltefosine 3.04 µM 1.69945228677825 0.036394281371723 no 213 0.0446169986682807 258 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1147 3809-1045 12.3 µM 1.68781388398277 0.0373923096383647 no 214 0.0457234807798192 334 325925 SGTC_974 1326-0144 138 µM 1.68472892544194 0.0376605697555945 no 215 0.0460204415579576 373 5411856 SGTC_1168 k815-0004 80.5 µM 1.68455744918204 0.0376755268676297 no 216 0.0460369933597507 310 642433 SGTC_1648 st011736 69.8 µM 1.67979220536776 0.038093121446449 no 217 0.0464988761257957 309 2855514 SGTC_1004 4084-0029 199 µM 1.67829919891036 0.0382247327743907 no 218 0.0466443521838278 350 716894 YLR208W SEC13 SGTC_2571 chrysanthemic acid 100 µM 1.67498330321053 0.038518361686095 no 219 0.0469687538363452 314 2743 An insecticide. SGTC_1470 k295-0292 231 µM 1.67344661283248 0.0386550605544568 no 220 0.0471197040481012 333 5045612 SGTC_2054 5233173 129 µM 1.6694010021687 0.0390168355327396 no 221 0.0475189675894585 405 6889 SGTC_521 r062-0005 13.8 µM 1.66925358065644 0.0390300704466119 no 222 0.0475335677215992 330 2832033 SGTC_3165 9101544 49.47 µM 1.66854909700167 0.0390933666487489 no 223 0.0476033870438281 346 5002184 SGTC_975 1335-0046 28.5 µM 1.66299775875721 0.039595070127829 no 224 0.0481564420648114 370 16486740 SGTC_2690 usnic acid 100 µM 1.66202977833557 0.0396830854024856 no 225 0.0482534019542324 399 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1089 terbinafine 2.25 µM 1.65292623727589 0.0405186473323178 no 226 0.0491729383001736 325 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2564 betulinic acid 100 µM 1.65240071713008 0.0405673145987822 no 227 0.0492264447245401 395 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1077 5-fluorocytosine 377 nM 1.64359295263228 0.0413900669503397 no 228 0.0501301553187619 325 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2338 7999974 200 µM 1.64300273431055 0.0414456805229204 no 229 0.0501911837655087 362 315925 SGTC_747 3448-8087 38.7 µM 1.63953194810022 0.0417739430040027 no 230 0.0505512613407979 380 5168703 SGTC_1137 ixabepilone 100 µM 1.63705565613198 0.0420094320719189 no 231 0.0508094204642083 386 154225 A novel microtubule stabilizer. SGTC_1871 st057448 67.3 µM 1.63694303843799 0.0420201672228467 no 232 0.0508211860272664 372 691747 SGTC_2173 5763948 167 µM 1.63415531220065 0.0422866125486821 no 233 0.0511131215690521 352 2867177 SGTC_1636 st007707 68.9 µM 1.63249400248422 0.0424460461548754 no 234 0.0512877304482295 402 403051 SGTC_2224 6650123 117.647 µM 1.63029037060457 0.0426582754529171 no 235 0.0515200708864889 290 2908370 SGTC_1693 xanthone 101.9 µM 1.62797240971631 0.0428824406346784 no 236 0.0517653680639203 358 7020 An insecticide. SGTC_2758 dehydroepiandrosterone 69.35 µM 1.62592044175428 0.0430816756686572 no 237 0.0519832904588285 386 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2378 9074213 121.43 µM 1.62003849216692 0.0436569278277405 no 238 0.052612004290581 389 657714 SGTC_724 3910-0327 137 µM 1.6194245889163 0.0437173228521577 no 239 0.0526779699110296 369 2885483 SGTC_2970 9090938 41.86 µM 1.61245709758892 0.0444075107962685 no 240 0.0534312543038077 456 17217104 SGTC_222 nsc-310342 10.666 µM 1.600452956298 0.0456171935016513 no 241 0.0547490676122796 222 432556 SGTC_2158 5657123 3.6195 µM 1.59890862605495 0.0457747243000465 no 242 0.0549204535399612 325 2858827 SGTC_746 1095-0025 46.6 µM 1.59844474789989 0.0458221279058652 no 243 0.0549720163061684 383 6749286 SGTC_3019 9081971 49.47 µM 1.5958675208373 0.0460862130781201 no 244 0.0552591871620312 356 16451803 SGTC_2806 7952793 58.44 µM 1.59188697919264 0.0464964949720923 no 245 0.0557050508711449 376 2972490 SGTC_3147 9097027 49.47 µM 1.58810471464504 0.0468890513251317 no 246 0.0561313311991972 365 25236841 SGTC_2738 aclarubicin 5.55 µM 1.58380423000272 0.0473386177301047 no 247 0.0566191382027645 264 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1179 1021-1431 9.29 µM 1.57977754736934 0.0477626863188954 no 248 0.0570789096084785 472 2840958 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.57970415799939 0.04777044342651 no 249 0.0570873164848606 407 688664 SGTC_1733 st037357 54.9 µM 1.57636800770389 0.0481241342442674 no 250 0.0574705084329368 424 1272339 YGL099W LSG1 SGTC_3160 9100216 49.47 µM 1.57528862150973 0.0482390158567692 no 251 0.0575949195970623 363 17191039 SGTC_976 1348-1067 47.6 µM 1.56181136207084 0.0496919817151458 no 252 0.0591662171730833 441 5310671 YGL099W LSG1 SGTC_2492 derrusnin 100 µM 1.55800042597229 0.0501091059461007 no 253 0.0596165735725603 310 1715307 Part of coumarin class of compounds. SGTC_740 k014-0057 261 µM 1.5576739640236 0.0501449681114354 no 254 0.0596552777101564 435 4012779 SGTC_2462 5162487 171.77 µM 1.55633409375307 0.0502923685413485 no 255 0.05981433411322 389 2259986 SGTC_1569 carminic acid 40.6 µM 1.55194033529509 0.0507781543354363 no 256 0.0603382502593477 391 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1878 temozolomide 1 mM 1.54868155597198 0.0511408613487282 no 257 0.0607291448901419 340 5394 DNA alkylating agent. SGTC_234 nsc-17383 10.7 µM 1.54604823597619 0.0514354573437102 no 258 0.0610464594213273 454 408974 SGTC_1082 camptothecin 424.86 nM 1.54385236953965 0.0516821449335014 no 259 0.0613120505473456 379 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1477 0139-0234 16 µM 1.54281410300677 0.0517991127018032 no 260 0.0614379433278048 367 620880 SGTC_3355 9151058 44.0485 µM 1.54007935199525 0.0521082080424008 no 261 0.0617705060769801 389 17015728 SGTC_2071 5230951 39.92 µM 1.5356517778817 0.0526117390205031 no 262 0.0623119039468757 422 1799272 SGTC_1625 st003711 30.1 µM 1.52925870553771 0.0533456030279884 no 263 0.0631001611732635 391 24207034 YER133W GLC7 SGTC_3316 9136639 10.545 µM 1.52223896772946 0.054160722161672 no 264 0.0639746072091932 380 4903665 SGTC_1270 0831-1170 17.3 µM 1.52093295091818 0.0543134563394919 no 265 0.0641383319857835 435 6764716 SGTC_732 3970-1727 52.7 µM 1.51782668115805 0.0546780930393399 no 266 0.0645290485242096 375 1275699 SGTC_315 k915-0449 187 µM 1.51128751118668 0.0554520333031355 no 267 0.0653576072314392 484 20970215 YNL149C PGA2 SGTC_2452 5863136 48.41 µM 1.50972335819719 0.0556384337364882 no 268 0.0655570142387748 416 2184096 SGTC_1391 3442-0225 151 µM 1.50881203503541 0.0557472640965131 no 269 0.0656734121497714 341 5227075 SGTC_2752 diclazuril 33.15 µM 1.50809594876539 0.0558328970343009 no 270 0.065764985969478 596 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2007 4011539 71.82 µM 1.50692689631899 0.0559729207639907 no 271 0.0659146982046722 444 45595301 SGTC_3059 1327-0034 3 µM 1.50346639120091 0.0563890280783857 no 272 0.0663594086898701 443 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_85 0868-0259 160.055 µM 1.50219817257213 0.0565421337194915 no 273 0.0665229683238567 381 83173 SGTC_2522 biochanin a 4.94 µM 1.49925421013105 0.0568988062185332 no 274 0.0669038482192574 374 5280373 A possible chelator. SGTC_227 fluconazole 33.516 µM 1.49663977738454 0.0572170381343405 no 275 0.0672435070425905 499 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2171 5739187 198.077 µM 1.49642424274846 0.0572433356472048 no 276 0.0672715679962775 363 2262761 SGTC_2067 5224629 34.075 µM 1.4963359713736 0.0572541084368009 no 277 0.0672830628637533 439 2835000 SGTC_316 k060-0003 58.6 µM 1.49513004386152 0.0574014417340804 no 278 0.0674402531673493 413 6152314 SGTC_771 0250-0039 27.3 µM 1.49483045918972 0.0574380894854989 no 279 0.0674793474246189 435 3005115 SGTC_841 0251-0215 91.2 µM 1.49311200747823 0.0576486608891155 no 280 0.0677039349708348 503 3888614 SGTC_485 niflumic acid 177 µM 1.49030549802547 0.0579938628315377 no 281 0.0680719637612433 381 4488 A COX2 inhibitor. SGTC_461 N-acetylfarnesylcysteine 136 µM 1.48963991134437 0.0580759681493775 no 282 0.0681594709579369 333 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2929 9013348 24.6 µM 1.48851943599456 0.0582143938257346 no 283 0.0683069801786195 432 2995952 SGTC_265 mycophenolic acid 32.932 µM 1.48628549148119 0.0584911530843134 no 284 0.06860181132765 457 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1432 4049-0298 68.4 µM 1.48217565145258 0.0590030112627497 no 285 0.069146781739506 401 741646 SGTC_2016 5121758 140 µM 1.47703439052796 0.0596482671885012 no 286 0.0698332094457458 486 2795203 SGTC_2519 cryptotanshinone 88.04 µM 1.47512292233456 0.0598895720077068 no 287 0.0700897494102903 389 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2347 9049783 174.81 µM 1.47246212723464 0.0602267444490297 no 288 0.0704480634745703 476 6467988 YPL169C MEX67 SGTC_587 k089-0003 57 µM 1.47215334495867 0.0602659689674372 no 289 0.0704897364503799 279 9659696 SGTC_626 0214-0009 33 µM 1.46417232650878 0.0612867490517415 no 290 0.0715734347100337 453 3437874 SGTC_3241 9133421 49.47 µM 1.46400355007394 0.0613084806836258 no 291 0.0715964891803607 343 17018221 SGTC_1295 1013-0063 9.78 µM 1.4631442225641 0.0614192209577948 no 292 0.0717139596946209 454 6826038 SGTC_2839 9003951 25.97 µM 1.46286006411958 0.0614558743957002 no 293 0.0717528368114318 400 2990634 SGTC_3129 9127257 49.47 µM 1.46279864695272 0.061463798806502 no 294 0.0717612417208689 391 837894 SGTC_2645 abamectin 100 µM 1.46279007770233 0.061464904525966 no 295 0.0717624144786491 445 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_229 benomyl 22.8748 µM 1.46176831711864 0.061596857168051 no 296 0.0719023544803556 469 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_428 3448-4153 16.5 µM 1.45321484600719 0.0627101665517332 no 297 0.0730820557173041 403 3834874 SGTC_2273 7815444 169.05 µM 1.44814436917427 0.0633774998236459 no 298 0.0737883395104753 424 2824616 SGTC_733 4069-0007 56.1 µM 1.44646784386519 0.0635993618383059 no 299 0.0740230124443979 536 5717425 YNL287W SEC21 SGTC_1747 st037496 66.6 µM 1.44224680427307 0.0641606269028661 no 300 0.0746163805506145 494 723305 SGTC_2906 7926292 26.41 µM 1.44080046125154 0.0643538280880833 no 301 0.074820531560475 466 2966319 SGTC_1246 0422-0085 105 µM 1.44079829575592 0.0643541176915808 no 302 0.0748208375388955 501 264295 SGTC_1322 1348-1070 12 µM 1.43883152988791 0.0646175623844542 no 303 0.0750991303758074 390 6758089 SGTC_2607 solasodine 47.35 µM 1.43872543575116 0.0646317972766977 no 304 0.075114164859695 475 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2440 5628896 157.78 µM 1.4376808546725 0.0647720811770224 no 305 0.0752623138671335 422 5522048 SGTC_1144 3486-0183 12.5 µM 1.43677576359394 0.0648938231001307 no 306 0.0753908595660624 478 6744069 SGTC_2088 5278280 127.392 µM 1.43506632058643 0.0651242412403376 no 307 0.0756340998667338 495 791502 SGTC_1413 3910-0535 34.4 µM 1.43317347600907 0.0653801205063998 no 308 0.0759041338262738 463 2876951 SGTC_1053 3366-3204 134 µM 1.43126696718625 0.0656386345519769 no 309 0.0761768586326363 509 3632071 YPR165W RHO1 SGTC_1236 0330-0013 258 µM 1.43125832106359 0.0656398087299821 no 310 0.0761780971513278 428 4617066 SGTC_1824 st053723 68.6 µM 1.42963905466263 0.0658599988352568 no 311 0.076410320203958 467 675225 SGTC_804 1595-0054 20.9 µM 1.42871126782391 0.0659864183003303 no 312 0.0765436189326815 443 761523 Stimulates phospholipase C. SGTC_2126 5251174 33.877 µM 1.42765303869922 0.0661308411715569 no 313 0.0766958746619908 563 790722 SGTC_772 k072-0172 35.3 µM 1.42118917359418 0.0670183252290601 no 314 0.0776308856168468 417 5861980 SGTC_490 phenamil 164 µM 1.42057463642744 0.0671031779917156 no 315 0.0777202281972896 339 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1115 galangin 695.678 nM 1.42038349594108 0.0671295868153215 no 316 0.0777480324717932 505 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3173 9105693 49.47 µM 1.41109051281548 0.0684232660856709 no 317 0.0791089635210595 506 17096658 SGTC_95 0471-0001 561.058 µM 1.40644462673619 0.0690771921008707 no 318 0.0797960682416648 491 4015405 SGTC_170 4197-0004 226 µM 1.40552057330164 0.0692078284788036 no 319 0.0799332679878513 414 218692 SGTC_1199 1638-0010 4.46 µM 1.40465206898708 0.0693307851501695 no 320 0.0800623825728602 514 3111136 SGTC_940 3232-1287 54.8 µM 1.40249952508418 0.0696362523402896 no 321 0.0803830661119731 478 1585493 YIL048W NEO1 SGTC_36 0335-0881 14.2 µM 1.39624552225254 0.0705296364266003 no 322 0.0813202863393912 558 23828853 SGTC_3299 9121982 43.1275 µM 1.3957496356058 0.0706008490780901 no 323 0.0813949508003591 491 17594604 YPL160W CDC60 SGTC_2729 fluphenazine 10.66 µM 1.39479611361669 0.0707379365175889 no 324 0.081538665602007 500 3372 An atypical antipsychotic. SGTC_2988 9073640 71.4286 µM 1.39430899647788 0.0708080480253149 no 325 0.0816121576850953 455 9102229 SGTC_1210 3013-0140 750 nM 1.39288090486562 0.0710139031319666 no 326 0.0818279038164535 499 905973 SGTC_1930 st074634 34.3 µM 1.39278812388892 0.0710272931150076 no 327 0.0818419353767756 503 684253 YOR116C RPO31 SGTC_2110 5483698 200 µM 1.38774723653616 0.0717577033244554 no 328 0.0826070133472081 468 2848765 YHR062C RPP1 SGTC_2315 7733312 200 µM 1.38627484467556 0.0719721322257087 no 329 0.0828314975212309 446 726316 SGTC_2789 5281112 71.43 µM 1.38587396816639 0.0720305980966447 no 330 0.0828926954757204 499 765948 SGTC_3205 9113483 49.47 µM 1.38410984424056 0.0722883196878314 no 331 0.0831624115374894 529 17018033 SGTC_2711 st079103 59.1 µM 1.38214264964229 0.0725765406387533 no 332 0.0834639526152485 450 54693780 SGTC_952 1185-0122 232 µM 1.37600976866793 0.073480742268694 no 333 0.0844093044620452 505 678600 SGTC_77 0828-0286 12.516 µM 1.37396138648196 0.0737846570670847 no 334 0.0847268351714581 516 745345 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.37356458795436 0.0738436402770275 no 335 0.08478844847198 452 2346 DNA damaging agent; causes G2/M arrest. SGTC_1452 4194-0072 190 µM 1.3718572305147 0.0740978462998188 no 336 0.0850539434834522 548 1343545 SGTC_1903 st060211 78.3 µM 1.36761514646054 0.0747323376122149 no 337 0.0857162864250069 511 688960 SGTC_2266 7929956 200 µM 1.36559561607636 0.0750358529438299 no 338 0.0860329616622279 528 2967153 SGTC_638 3970-0837 4.09 µM 1.36218432251017 0.0755506703518617 no 339 0.0865698610960935 511 4118451 YLR208W SEC13 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.36173844960033 0.0756181579289684 no 340 0.0866402211735852 487 803109 SGTC_3041 9091929 49.47 µM 1.3602514902373 0.0758435569635016 no 341 0.086875176761613 524 25236887 SGTC_2849 9019321 12.99 µM 1.34947422475751 0.0774925362773809 no 342 0.0885923469504259 473 16489627 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.34944963256464 0.0774963299017242 no 343 0.0885962939936517 551 688667 SGTC_99 0109-0120 622.8 µM 1.34759338442357 0.0777830844708611 no 344 0.0888945997701244 461 759414 SGTC_2447 5741742 33.78 µM 1.34741766187979 0.077810271891418 no 345 0.0889228777157908 529 1776504 SGTC_2471 5466956 24.79 µM 1.34706930367262 0.0778641904576811 no 346 0.0889789566507611 464 724419 SGTC_2857 9024691 58.44 µM 1.34204093394694 0.0786456387412368 no 347 0.0897913618133746 484 16478292 SGTC_1811 st050069 61.5 µM 1.34191342018482 0.0786655323777237 no 348 0.0898120349351682 452 3877702 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.34113349752738 0.0787872924284739 no 349 0.0899385566116868 519 688669 SGTC_911 3456-4043 236 µM 1.33691134163566 0.0794489275799164 no 350 0.0906257891283227 538 914281 SGTC_2015 5119600 184 µM 1.33396858647881 0.0799125545122012 no 351 0.091107075928389 521 2828786 SGTC_663 1486-0733 13.9 µM 1.33390034623414 0.0799233298869873 no 352 0.0911182590470107 581 722445 YPR165W RHO1 SGTC_2617 dihydrotanshinone i 20.83 µM 1.32819730793199 0.0808277477992195 no 353 0.0920564667627264 568 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_216 k038-0035 28.382 µM 1.32678879331325 0.0810523028281822 no 354 0.0922892793064291 474 4444231 YPR107C YTH1 SGTC_2628 lathosterol 100 µM 1.32224858989749 0.0817793382207742 no 355 0.0930426928922376 534 6710616 SGTC_1407 3909-7909 12.3 µM 1.32081949189784 0.0820091978078322 no 356 0.0932807794211477 555 4411780 SGTC_720 r052-1644 49.9 µM 1.32044000219469 0.0820703175696787 no 357 0.0933440776577298 462 1422863 YOR257W CDC31 SGTC_816 0325-0417 81.3 µM 1.31804525407137 0.0824568021416183 no 358 0.0937442496455994 503 68101 SGTC_2546 rhodinyl acetate 100 µM 1.3129714604367 0.0832801782797945 no 359 0.0945962825954561 548 6708682 SGTC_2115 tiliquinol 12.7705 µM 1.30899710466217 0.0839294428719223 no 360 0.0952676657471206 500 71208 A bioactive hydroxyquinoline. SGTC_1781 st038725 66.3 µM 1.30159507561706 0.0851487846989246 no 361 0.0965274220476062 634 4270275 YIL048W NEO1 SGTC_152 4469-0003 551.229 µM 1.29873305093014 0.0856237903110245 no 362 0.0970177787020557 522 697280 SGTC_2244 6635614 200 µM 1.29184905900596 0.086774436665692 no 363 0.098204710969203 403 836499 SGTC_430 0958-0115 16.4 µM 1.2889810915085 0.0872572071594251 no 364 0.0987023301216681 537 6833180 SGTC_2610 ononetin 44.17 µM 1.28258163739924 0.0883416646133548 no 365 0.099819343407432 581 259632 SGTC_417 st075190 100 µM 1.28206770952993 0.0884291890776162 no 366 0.0999094475475057 587 222757 SGTC_2608 thymoquinone 42.66 µM 1.27876210315914 0.0889936950914586 no 367 0.100490421426965 501 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1183 1254-0324 198 µM 1.27726283540558 0.0892506109393499 no 368 0.100754734872851 573 5799357 SGTC_83 0170-0301 39.027 µM 1.27466021249269 0.0896979085104319 no 369 0.101214767661637 431 3089716 SGTC_2240 6690706 185.951 µM 1.27283474671444 0.090012633632244 no 370 0.101538344201989 475 805876 SGTC_1354 1498-1681 81 µM 1.27254820522219 0.0900621101296038 no 371 0.10158920401191 605 5754243 SGTC_2882 9058044 58.44 µM 1.27195356069348 0.0901648505804895 no 372 0.101694809898885 535 18076804 SGTC_262 fenpropimorph 62.5 µM 1.27152146263591 0.0902395614633298 no 373 0.101771598474179 503 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2696 st077691 74.316 µM 1.26388052586402 0.0915683049470582 no 374 0.103136456274944 512 757133 SGTC_235 0330-0087 5 mM 1.26169553466765 0.0919509232496599 no 375 0.10352918215363 592 46494818 YHR062C RPP1 SGTC_1560 lithocholic acid 53.1 µM 1.26071020663321 0.0921238528999423 no 376 0.103706637634568 476 9903 A bile acid which acts as a detergent. SGTC_2654 protoveratrine a 100 µM 1.2603186926534 0.0921926322246665 no 377 0.103777209697343 565 5702278 A heart drug and vasodilator. SGTC_645 0845-0943 5.41 µM 1.25754992875038 0.0926801208280551 no 378 0.104277285708652 567 1885106 SGTC_74 000s-0487 160.283 µM 1.25370293296615 0.0933606118217889 no 379 0.104975000745199 562 677548 SGTC_2545 solidagenone 89.61 µM 1.25219307708929 0.0936286948318137 no 380 0.10524975900306 357 6708572 An anti ulcer agent SGTC_2847 9005661 71.43 µM 1.24957971169499 0.0940940545467698 no 381 0.105726559107353 443 2991449 SGTC_2321 7390090 138.78 µM 1.24644172792923 0.0946550846418508 no 382 0.106301134934703 514 649046 SGTC_62 0180-0423 3.232 µM 1.23828081391767 0.0961256858674261 no 383 0.107805977650679 568 30102 YGL099W LSG1 SGTC_3005 9076496 71.4286 µM 1.23082204732655 0.097484389595582 no 384 0.109194713855676 553 21368410 SGTC_3092 9117248 49.47 µM 1.22799954549897 0.0980021988706058 no 385 0.109723569297122 631 17141857 SGTC_1226 3909-7979 35.4 µM 1.22677619986195 0.09822725589531 no 386 0.109953359266065 653 6615510 SGTC_591 4299-0174 154 µM 1.22629861420036 0.0983152192680753 no 387 0.110043161334245 590 5509088 SGTC_1952 st077036 64.1 µM 1.22450443806752 0.0986461922872285 no 388 0.110380996567343 606 2937007 SGTC_1530 rhein 70.4 µM 1.21914657103216 0.0996394149956905 no 389 0.111394283290941 649 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1444 4112-3581 28 µM 1.21555761355158 0.100308797797608 no 390 0.112076744515135 610 2877249 SGTC_285 1486-1325 46 µM 1.21492521998715 0.100427085955432 no 391 0.112197306926209 637 22310230 SGTC_3305 9127027 53.8275 µM 1.21413468176279 0.100575097913269 no 392 0.11234814908567 607 41905295 SGTC_880 0833-0487 87.2 µM 1.21030837474292 0.101293744338933 no 393 0.113080292655844 592 76075 SGTC_373 0844-0104 25.9 µM 1.20799860724514 0.101729365398248 no 394 0.113523899034758 657 5375804 SGTC_3076 9116187 49.47 µM 1.20596831343035 0.10211340283046 no 395 0.11391485416868 562 27241210 SGTC_2985 9022375 71.43 µM 1.20503850629509 0.102289630926568 no 396 0.114094218557926 621 4939335 SGTC_2420 aureobasidin a 50 nM 1.20387703331164 0.102510077691881 no 397 0.114318554916061 665 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1033 k072-0102 21.3 µM 1.20386463648616 0.102512432462286 no 398 0.114320951032804 633 5965931 SGTC_2770 toltrazuril 17.5 µM 1.19704230179031 0.103814304172994 no 399 0.115645033577454 671 68591 Kills coccidiodes. SGTC_32 0928-0142 34.1 µM 1.19516554935573 0.104174529682392 no 400 0.116011177820813 584 2244242 SGTC_3254 9136651 49.47 µM 1.19403450215632 0.104392060990664 no 401 0.116232236036558 650 16454030 SGTC_2788 5282734 71.43 µM 1.19286211729775 0.104617889885832 no 402 0.116461688838187 693 743706 SGTC_568 1193-0097 7.48 µM 1.19254074225872 0.104679856027214 no 403 0.116524642687372 643 3646150 SGTC_3277 9138724 49.47 µM 1.19171244815436 0.104839686642963 no 404 0.116687007682809 506 15943418 SGTC_543 3844-1095 191 µM 1.19138518830589 0.104902884557398 no 405 0.1167512024484 675 4230703 SGTC_1141 3253-0389 52.6 µM 1.1877354895203 0.105609556088975 no 406 0.117468818526501 609 5402031 SGTC_1323 1348-1351 11.2 µM 1.18579239809243 0.105987187592076 no 407 0.117852147172644 599 6989654 SGTC_1394 3474-0001 65.7 µM 1.18468199273416 0.106203427755666 no 408 0.118071602413617 554 5017666 YIL048W NEO1 SGTC_1941 st076221 61.8 µM 1.18261705762322 0.10660639988629 no 409 0.118480474565643 688 2828568 SGTC_798 1287-0182 476 µM 1.18207405756149 0.10671254939483 no 410 0.118588158499333 700 1649755 SGTC_149 3970-0822 46.1 µM 1.17990985690082 0.107136380553432 no 411 0.119018034546496 782 3114250 YBL034C STU1 SGTC_338 4055-0136 114 µM 1.17816055667597 0.107479844859295 no 412 0.119366301962875 636 2900563 SGTC_1931 st074438 57.1 µM 1.17779488963865 0.107551741495994 no 413 0.119439193234136 611 2787313 SGTC_2917 7979103 53.79 µM 1.17763310788074 0.107583561720452 no 414 0.119471452476573 696 2980565 SGTC_873 0591-4978 488 µM 1.1765996596441 0.107786986715751 no 415 0.119677666852159 696 3305145 SGTC_2693 st077581 40.7 µM 1.17593657587617 0.107917654628638 no 416 0.119810110792007 734 25238761 SGTC_2352 9027995 87.8 µM 1.17520092326791 0.108062756469267 no 417 0.119957170479328 584 2997347 SGTC_3286 9117135 37.221 µM 1.17473650750276 0.108154431218533 no 418 0.120050074407218 610 3438150 SGTC_2233 sulbentine 40.3845 µM 1.17375845043465 0.108347680814732 no 419 0.120245895398308 704 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2163 5671233 125 µM 1.1730757083647 0.108482727726337 no 420 0.120382723416891 690 701023 SGTC_9 0092-0002 10.449 µM 1.17252642836115 0.108591463609888 no 421 0.120492883943489 659 759368 SGTC_2939 9044578 71.43 µM 1.17149317396067 0.10879621982671 no 422 0.12070029999954 624 2653634 SGTC_918 glabranin 770.725 nM 1.17072605143279 0.108948417131478 no 423 0.120854455086145 653 124049 Also referred to as licorice root. SGTC_846 0335-0850 148 µM 1.16767007709783 0.109556242433509 no 424 0.121469935611574 618 6819598 SGTC_293 4049-0273 38.5 µM 1.16558483920614 0.109972386055903 no 425 0.121891170220197 616 1380311 SGTC_2866 9034245 58.44 µM 1.16358230876464 0.110373090525786 no 426 0.122296662143909 615 6462273 SGTC_1109 tnp00067 928.257 nM 1.15897647382639 0.111298684225231 no 427 0.123232887400305 660 676295 SGTC_2465 5809242 33.21 µM 1.15670000457072 0.111758212377282 no 428 0.123697473915728 646 2731748 SGTC_25 0118-0223 35.662 µM 1.15552662858913 0.111995599408904 no 429 0.123937417255919 650 5333628 SGTC_3020 9089140 49.47 µM 1.15019568763553 0.113078647763829 no 430 0.125031640990052 639 17217859 SGTC_2028 5153890 36.43 µM 1.15010397522397 0.113097345475096 no 431 0.125050524647622 653 2830968 YPR165W RHO1 SGTC_1797 st048695 56.8 µM 1.14965568790966 0.113188771033016 no 432 0.125142856022761 668 592262 YIL048W NEO1 SGTC_3061 glucosamine 200 µM 1.14649444147221 0.113834985845392 no 433 0.125795312929169 631 91431 and experimental redox chemotherapeutic SGTC_2389 9091542 195.52 µM 1.14634857830814 0.113864866188965 no 434 0.125825475122925 692 3626624 YOL127W RPL25 SGTC_2819 7996655 46.38 µM 1.14514274676839 0.114112097151561 no 435 0.126075015218639 571 6456960 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.13873455228301 0.115432381505989 no 436 0.127406943339118 568 1241132 A phosphatase inhibitor. SGTC_2097 5376186 200 µM 1.13735181193449 0.115718686597144 no 437 0.127695621638471 679 742755 SGTC_2873 9040596 71.43 µM 1.13713956172206 0.115762678953309 no 438 0.12773997388745 677 6463863 SGTC_22 0964-0034 14.468 µM 1.13542586200582 0.116118306614017 no 439 0.128098464398377 705 138402 SGTC_1460 k062-0059 9.15 µM 1.13524783394554 0.116155295482462 no 440 0.128135746291431 667 1373085 SGTC_3117 9124945 49.47 µM 1.13518219746129 0.116168934876462 no 441 0.128149493511194 594 17592065 SGTC_1842 st055362 61.2 µM 1.13489874403064 0.116227850125161 no 442 0.128208873119714 723 676032 SGTC_1911 st060208 74.3 µM 1.13165368456524 0.116903840639405 no 443 0.128890030279043 709 688783 SGTC_1250 0485-0349 40.2 µM 1.13111657877236 0.117015995399805 no 444 0.129003013621324 629 6842794 YDL195W SEC31 SGTC_10 0279-0212 42.575 µM 1.13004002264118 0.117241024017804 no 445 0.129229680238455 780 39851 YBR002C RER2 SGTC_1441 4106-0040 13 µM 1.12715797702453 0.117844955764463 no 446 0.129837847116562 674 2904180 SGTC_70 0141-0289 43.283 µM 1.12676884799813 0.117926665993165 no 447 0.129920112399069 875 352408 SGTC_1472 k841-0093 193 µM 1.12464114734416 0.118374154347879 no 448 0.130370564981799 720 X1472 SGTC_2356 9061756 188.97 µM 1.12407187235353 0.11849408496441 no 449 0.130491268381557 653 20104043 SGTC_890 0929-0006 47.2 µM 1.12130287750043 0.119078660873211 no 450 0.131079480567642 659 1378169 SGTC_2597 laccaic acid a 100 µM 1.12125503579562 0.119088778828919 no 451 0.131089659559373 710 5491415 A textile dye. SGTC_89 0302-0250 142.109 µM 1.12087879034577 0.11916837145594 no 452 0.131169730073985 731 4203518 YLR208W SEC13 SGTC_169 k015-0017 16.025 µM 1.11919162337843 0.119525743933212 no 453 0.131529199136061 624 1840002 SGTC_965 1291-5240 308 µM 1.11752661129318 0.119879164167223 no 454 0.131884613950569 717 2834598 SGTC_3013 9080133 71.4286 µM 1.11506669856464 0.120402659525216 no 455 0.132410920359721 750 17050193 SGTC_1626 st003712 1.76 µM 1.10707299047137 0.122114915010779 no 456 0.134131186024683 661 24207035 SGTC_1237 0330-0133 46.1 µM 1.10548754819283 0.12245653929854 no 457 0.134474193472458 670 X1237 YHR072W ERG7 SGTC_1602 st001878 87.6 µM 1.10017135328741 0.123606942714317 no 458 0.135628734777751 701 595405 YLR310C CDC25 SGTC_2193 5925765 200 µM 1.09910063528688 0.123839554505053 no 459 0.135862086428796 643 877370 SGTC_1778 st046819 58.9 µM 1.09909655214132 0.123840442148051 no 460 0.135862976833023 750 671715 SGTC_343 4130-2827 29.8 µM 1.09565792901687 0.124589552863258 no 461 0.136614250192168 729 1118244 SGTC_3221 9128209 49.47 µM 1.08825723092412 0.126212539085561 no 462 0.138240782874186 680 16460723 SGTC_67 0335-0847 266 µM 1.08482977679877 0.126969156951621 no 463 0.138998527322484 841 4552207 YOR254C SEC63 SGTC_3179 9107801 49.47 µM 1.08379277564044 0.127198698009214 no 464 0.13922834454954 715 4818259 SGTC_2426 5582046 32.21 µM 1.08368078445481 0.127223504612723 no 465 0.139253179176585 733 2251934 SGTC_676 falcarinol 140 µM 1.08276708864683 0.127426018518968 no 466 0.139455908585023 747 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_116 0155-0182 31.788 µM 1.08098492839609 0.127821665965053 no 467 0.139851908965439 841 771486 SGTC_115 0527-0192 112.043 µM 1.08074388277108 0.127875244630761 no 468 0.13990552851684 808 4233931 SGTC_1518 st038567 90.8 µM 1.07906715397966 0.12824837310073 no 469 0.140278896150858 710 77966 SGTC_2425 5628681 7.85 µM 1.0786388545003 0.128343805224821 no 470 0.140374376669623 819 5714958 SGTC_622 1348-1566 26.3 µM 1.07789245128131 0.128510233867917 no 471 0.140540877288049 778 7340407 SGTC_2652 actinonin 100 µM 1.0772889001244 0.128644919679188 no 472 0.140675609802844 696 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1771 st048882 4.1505 µM 1.07273970124878 0.129663250460603 no 473 0.141693961028338 715 4580403 SGTC_1755 st041960 45.185 µM 1.07207548497051 0.129812400012936 no 474 0.141843064463886 728 2257073 SGTC_2747 doxorubicin 7.63 µM 1.07040780572413 0.130187400286553 no 475 0.142217893650047 551 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2508 celastrol 40.54 µM 1.06820159760951 0.130684646871662 no 476 0.142714792139669 680 122724 Celastrol is a natural product and antioxidant. SGTC_1191 1487-1166 10.6 µM 1.0675271894934 0.130836910142849 no 477 0.14286692127415 822 3955771 SGTC_787 4152-0075 138 µM 1.06697862788321 0.130960851040048 no 478 0.142990743476082 713 9566539 SGTC_2665 lovastatin 100 µM 1.06615315307492 0.13114750999448 no 479 0.143177207592877 715 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2863 9028737 58.44 µM 1.06527776224874 0.131345656801937 no 480 0.143375126462611 719 6460917 SGTC_1410 3909-8106 77.9 µM 1.06527444258091 0.13134640860992 no 481 0.143375877364412 730 1039210 SGTC_1821 st053465 65.6 µM 1.05957016522062 0.132642652377541 no 482 0.144670096297779 715 675086 SGTC_1213 1315-0166 115 µM 1.05756585789726 0.133100197639643 no 483 0.145126707457562 637 768401 SGTC_260 nsc-65238 3.989 µM 1.05530632569141 0.133617307098212 no 484 0.145642624491566 722 3246252 SGTC_1220 1838-0075 193 µM 1.0551321701214 0.133657221059037 no 485 0.145682440402979 758 5529645 SGTC_2124 5246320 200 µM 1.05468476515395 0.133759797445073 no 486 0.145784760865962 724 579342 SGTC_2247 cerulenin 830 nM 1.05293238534488 0.134162085985133 no 487 0.146185991038224 750 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_268 camptothecin 39.6153 µM 1.04784686879149 0.135334255114171 no 488 0.147354582333076 843 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1329 1447-1697 50.6 µM 1.04516746299382 0.135954651144429 no 489 0.147972789240308 747 2840515 SGTC_466 geldanamycin 89.2 µM 1.04495361203534 0.136004250477936 no 490 0.148022204783791 640 5288382 HSP90 inhibitor. SGTC_3237 9133362 49.47 µM 1.0446923796761 0.136064855981589 no 491 0.14808258395496 754 43845137 SGTC_2251 lansoprazole 556 µM 1.04354570526764 0.136331101321306 no 492 0.148347812104581 603 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_350 k064-0020 19.8 µM 1.04291781872885 0.136477040679917 no 493 0.14849317810356 806 2790705 SGTC_1469 k284-2957 126 µM 1.04179243105563 0.136738881298639 no 494 0.14875396203664 737 23884841 SGTC_1734 st037168 69.4 µM 1.04080899411916 0.136967975680212 no 495 0.148982102475083 747 708907 SGTC_2713 st079149 53.4 µM 1.03966472730684 0.137234865805004 no 496 0.149247846751728 780 3103253 SGTC_2245 6637752 200 µM 1.0380631699692 0.137609011060172 no 497 0.149620323305983 657 681890 SGTC_139 0099-0334 718.624 µM 1.03739493291802 0.137765325851766 no 498 0.149775919422567 886 97690 SGTC_1867 st057372 64 µM 1.03532206554499 0.138250984046502 no 499 0.150259264160745 749 688837 SGTC_399 oxolinic acid 75 µM 1.03476560017414 0.138381558438397 no 500 0.1503891958106 747 4628 A DNA gyrase inhibitor. SGTC_2370 9071495 200 µM 1.03391840056436 0.138580514865123 no 501 0.150587156033428 721 21791103 SGTC_811 0416-0114 265 µM 1.02311590816324 0.141134460395118 no 502 0.153126523103645 754 6612453 SGTC_1071 trifluoperazine 6.31 µM 1.02072091457477 0.141704984305521 no 503 0.153693341345045 810 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2183 6420625 130.508 µM 1.01926684257862 0.142052127481982 no 504 0.154038150430018 831 2897619 SGTC_3288 9119690 36.221 µM 1.01714883082423 0.142558807891193 no 505 0.154541316839935 706 17595618 YKL019W RAM2 SGTC_2999 9069765 71.4286 µM 1.01509210253831 0.143051996090074 no 506 0.155030962927391 799 2097066 SGTC_3203 9113543 49.47 µM 1.01427695194075 0.143247781767108 no 507 0.155225309301603 735 17018012 SGTC_2141 5621638 7.665 µM 1.01251333305006 0.14367199292066 no 508 0.155646337485992 794 2856238 SGTC_3078 9116413 49.47 µM 1.00966826733532 0.144358114637563 no 509 0.156327125257955 733 17177322 SGTC_2254 7938975 95.19 µM 1.00946478130618 0.144407272215727 no 510 0.156375891900903 865 2969277 SGTC_640 3381-0960 37.1 µM 1.00878764339737 0.144570934494066 no 511 0.156538244185235 841 1745025 SGTC_1418 3966-3099 2.4 µM 1.00669321895304 0.145077941601073 no 512 0.157041110896625 814 740335 SGTC_1359 1582-0056 520 nM 1.00634267230242 0.145162916836121 no 513 0.157125380066116 848 3661189 SGTC_2980 9014342 25.29 µM 1.00533986710653 0.145406189543083 no 514 0.157366612200961 734 2996599 SGTC_1278 0874-0585 172 µM 1.00370342413217 0.145803766402945 no 515 0.157760793063829 804 766306 SGTC_1923 st058458 19.1 µM 1.0025514198315 0.146084085813918 no 516 0.158038672609056 859 3534982 SGTC_2191 5911152 200 µM 1.00242292480195 0.146115375183777 no 517 0.158069687313363 795 2875902 SGTC_3190 9110366 49.47 µM 0.997397166958995 0.147342711515075 no 518 0.159285882971619 703 17123768 SGTC_1819 st053448 58.6 µM 0.996929912394527 0.147457169391991 no 519 0.159399265591918 800 2857616 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.996729610603389 0.147506253213152 no 520 0.159447886413413 819 5282309 SGTC_1519 esterone 74 µM 0.990781302893472 0.148968871640278 no 521 0.160896190469104 810 698 A steroid. SGTC_292 k038-0015 474 µM 0.989605874078198 0.149259038263895 no 522 0.161183398874517 784 46368540 SGTC_784 4579-0127 173 µM 0.989108699606352 0.149381884364206 no 523 0.161304980829323 875 1948547 SGTC_837 0091-0265 12.5 µM 0.988840551722007 0.149448168636748 no 524 0.161370580107809 831 759367 SGTC_1578 josamycin 24.2 µM 0.987693659481098 0.149731893863146 no 525 0.161651350350605 739 5282165 A P450 substrate. SGTC_1906 st060206 94.7 µM 0.986472798920627 0.150034312430815 no 526 0.161950578427329 876 5133468 SGTC_2761 levamisole 97.89 µM 0.98500579792014 0.150398240605338 no 527 0.162310611516709 800 26879 An alkaline phosphatase inhibitor. SGTC_824 1304-0008 100 µM 0.984006803994022 0.150646403673391 no 528 0.16255608374944 821 768245 SGTC_2264 7948757 110.76 µM 0.983980589568786 0.150652919346765 no 529 0.162562528394159 780 2971411 SGTC_263 alizarin 107.927 µM 0.98373885623067 0.150713011731461 no 530 0.162621964786209 878 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1728 st035614 33.7865 µM 0.977867121000229 0.152177566073599 no 531 0.16407002425256 879 15945546 SGTC_899 1083-0020 478 µM 0.977122286422932 0.152364019156614 no 532 0.164254307814291 845 767123 SGTC_2114 5491910 81.25 µM 0.976504781766052 0.152518712891468 no 533 0.164407189715506 826 2849228 SGTC_3348 9149464 3.537 µM 0.974903910523353 0.152920239154261 no 534 0.164803963086132 831 1951442 SGTC_1442 4112-3290 3 µM 0.974167115476601 0.153105275436312 no 535 0.164986784810617 858 704353 SGTC_1815 st051655 58.2 µM 0.971554066429964 0.153762703935755 no 536 0.165636221673402 832 5984156 SGTC_1197 1601-0112 267 µM 0.969933406003244 0.15417139056408 no 537 0.166039843665063 845 7350313 SGTC_460 trequinsin 123 µM 0.969487078708478 0.154284068275594 no 538 0.166151112033492 900 5537 A vasodilator. SGTC_2009 4012297 12.05 µM 0.96780561267494 0.154709052294323 no 539 0.166570730094459 766 45595307 SGTC_1887 st057648 70.8 µM 0.966754838393329 0.154975023769107 no 540 0.166833302934376 831 688672 SGTC_1152 3909-8331 15.9 µM 0.966658878921178 0.154999328022695 no 541 0.166857295075624 807 16001939 SGTC_2396 5342950 42.78 µM 0.963419202752087 0.155821337926831 no 542 0.16766859671296 838 1886677 SGTC_2894 9048625 32.47 µM 0.95968762707038 0.156771714110343 no 543 0.168606226133026 845 4092861 SGTC_2782 7736369 71.43 µM 0.959047885847379 0.156935028824877 no 544 0.168767311100635 865 2950836 YOL077C BRX1 SGTC_366 0181-0206 4.31 µM 0.957389400478639 0.157358932068338 no 545 0.169185373210521 888 274874 SGTC_38 0929-0051 58.268 µM 0.95530553205772 0.157892627807919 no 546 0.169711605366398 896 1379719 SGTC_2903 5923464 63.88 µM 0.954578701895647 0.158079054213711 no 547 0.169895395968399 832 2876576 SGTC_2982 9019404 25.97 µM 0.954424300105714 0.158118675697596 no 548 0.169934455351799 718 22333232 SGTC_34 0469-0683 81.75 µM 0.953690525822974 0.158307060699356 no 549 0.170120158636383 860 3690923 SGTC_2450 5739737 12.93 µM 0.952561369590421 0.158597241347278 no 550 0.170406178957676 791 2262825 SGTC_2969 9091408 28.7 µM 0.951679372738297 0.158824147252466 no 551 0.170629806821956 798 4286311 SGTC_1313 1220-0047 237 µM 0.950524839318084 0.159121488376786 no 552 0.170922819368658 885 3528706 SGTC_447 ml7 120 µM 0.94956136384249 0.159369902963954 no 553 0.171167589015103 868 4216 Selective myosin light chain kinase inhibitor. SGTC_237 nikkomycin 200 µM 0.94794963333572 0.159786025662315 no 554 0.171577547823613 888 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1283 0922-0125 16.4 µM 0.946649931477965 0.160122104877855 no 555 0.171908595763258 921 3360884 SGTC_1507 4075-3230 155 µM 0.945116743454235 0.160519153071139 no 556 0.172299639078539 797 659771 SGTC_2304 7443016 91.4 µM 0.944963400301119 0.160558899547584 no 557 0.172338780815487 791 939854 SGTC_1260 0700-1617 7.75 µM 0.942993685484856 0.161070020353385 no 558 0.172842066390421 863 2853078 SGTC_1792 st045773 43.6 µM 0.94277737184114 0.161126216161766 no 559 0.172897394125164 829 2919270 SGTC_1998 st075797 76.8 µM 0.942224210363374 0.161269979360362 no 560 0.173038930614194 943 24208315 SGTC_1516 st013856 110 µM 0.939911250554079 0.161872009198937 no 561 0.173631542973337 821 5281404 A mutagen and neurotoxin. SGTC_3040 9091894 49.47 µM 0.939526820115674 0.161972212586558 no 562 0.173730164384673 787 25236966 SGTC_2777 climbazole 1.536 µM 0.938438815070936 0.162256024564434 no 563 0.174009473234784 896 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1880 MG-132 525 µM 0.938333140540584 0.162283607574864 no 564 0.174036616833592 821 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_56 0957-0365 83.25 µM 0.938299802412008 0.162292310077515 no 565 0.174045180636109 855 6752360 SGTC_1178 0988-0033 191 µM 0.935566138194165 0.163006932763084 no 566 0.174748307914597 865 5392207 SGTC_1957 st077035 62.4 µM 0.933501405899598 0.16354804006715 no 567 0.175280572451892 901 705593 SGTC_1117 retinoic acid 1.10837 µM 0.933497270711969 0.163549124950647 no 568 0.175281639486773 933 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1765 st044815 90.4 µM 0.93294207757015 0.163694824589366 no 569 0.175424937725152 852 645695 SGTC_632 0781-2353 4.65 µM 0.932883324938918 0.163710248003185 no 570 0.175440106429057 889 6811515 YHR007C ERG11 SGTC_2073 5212005 126 µM 0.93210322148135 0.16391512583765 no 571 0.175641591675486 783 691789 SGTC_3154 9100113 49.47 µM 0.928513084794665 0.164860143726416 no 572 0.176570741796251 866 25237525 SGTC_2272 7805186 180 µM 0.928085820955913 0.164972845249371 no 573 0.176681527001682 890 2956062 YPR165W RHO1 SGTC_497 capsazepine 133 µM 0.921645165456791 0.166677771179905 no 574 0.178356845754021 890 2733484 A calcium channel blocker. SGTC_3133 9127736 49.47 µM 0.921035071050392 0.166839858637987 no 575 0.178516058505507 881 27243420 SGTC_1397 3532-0190 20.1 µM 0.91951053918255 0.167245334561087 no 576 0.178914297814737 823 5322280 SGTC_2424 5537928 59.2 µM 0.918728276870789 0.16745363728609 no 577 0.179118857816799 909 5382802 SGTC_396 dithiazanine 1.25 µM 0.918203934137471 0.16759335408733 no 578 0.179256054702115 845 10578 An antihelmenthic. SGTC_3101 9120531 49.47 µM 0.914071770549617 0.168697040367471 no 579 0.180339567345745 898 24824904 SGTC_1174 0739-0097 51.1 µM 0.910289991295168 0.169711224643505 no 580 0.181334797744677 889 728447 SGTC_463 ikarugamyin 104 µM 0.909066068617127 0.17004028779847 no 581 0.181657626071647 908 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2108 5365811 200 µM 0.907592965655336 0.170436887357432 no 582 0.182046656089956 938 780283 SGTC_1229 0139-0193 12.2 µM 0.906706737929466 0.170675769245005 no 583 0.182280949678003 953 3090752 SGTC_2830 7992007 71.43 µM 0.905882712231521 0.170898076821096 no 584 0.18249896778384 853 1952075 SGTC_827 3253-0474 693 µM 0.90564677557304 0.170961762465818 no 585 0.18256142113855 947 5402065 SGTC_2077 5212015 200 µM 0.905018024216484 0.17113155348684 no 586 0.18272791924982 861 780900 SGTC_413 propylparaben 100 µM 0.900707127219545 0.172298591744784 no 587 0.183872029099453 889 7175 A pharmaceutical preservative. SGTC_199 4063-0024 41.6 µM 0.900457420270167 0.172366347182237 no 588 0.183938437613922 933 306215 SGTC_2677 mitomycin C 100 µM 0.898590990077817 0.172873322209363 no 589 0.184435279798001 886 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3306 9127676 59.7925 µM 0.89574855263262 0.173647231820805 no 590 0.185193536374825 887 41905287 SGTC_698 k064-0052 127 µM 0.893214377214111 0.174339066739614 no 591 0.185871190116624 929 5088751 SGTC_2376 9072922 81.32 µM 0.892676659243049 0.174486089725156 no 592 0.186015176656258 925 17087968 SGTC_3182 9108849 49.47 µM 0.892436247403356 0.174551848659994 no 593 0.186079574902891 949 17133045 SGTC_287 k060-0039 29.6 µM 0.890306597938452 0.175135050627381 no 594 0.186650639650213 950 5861974 SGTC_1562 morin hydrate 59.1 µM 0.888129120740518 0.175732626524818 no 595 0.187235649954805 894 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_623 k072-0108 16.9 µM 0.887662983278037 0.175860718612464 no 596 0.187361031611579 913 5382803 SGTC_855 0428-0020 25 µM 0.885387921619879 0.176486741733458 no 597 0.187973722265207 841 6812414 SGTC_52 0329-0193 875 nM 0.884283253274457 0.176791218357069 no 598 0.188271663085261 887 3739292 SGTC_2825 7998094 58.44 µM 0.884055164815977 0.176854127070456 no 599 0.188333217242986 882 2987815 SGTC_2109 5483026 200 µM 0.883777817744979 0.176930640782411 no 600 0.188408081530162 928 759335 SGTC_2694 st077685 81.9 µM 0.883088547101344 0.177120885364958 no 601 0.188594215813911 903 2838096 SGTC_2218 6965428 192.983 µM 0.876628716372289 0.178910129830101 no 602 0.190344168205402 944 675684 SGTC_1284 0929-0043 16 µM 0.876476055948495 0.17895255085461 no 603 0.19038564381053 938 1239883 SGTC_2330 7979373 200 µM 0.872874225389222 0.179955257419638 no 604 0.191365818218199 908 1863007 SGTC_2905 7799065 20.05 µM 0.865398159923362 0.182047740246327 no 605 0.193410145305797 921 1296806 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.862043486254799 0.182991607438078 no 606 0.194331794156609 992 165521 SGTC_1415 3966-0071 78.1 µM 0.861726545817889 0.18308093904095 no 607 0.19441900707227 951 2893185 SGTC_1583 clindamycin 39.6 µM 0.861410939764244 0.183169921569072 no 608 0.1945058764762 848 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3087 9117406 49.47 µM 0.860236602252807 0.183501253227513 no 609 0.194829315988367 908 42546093 SGTC_2493 resveratrol 26.09 µM 0.857483381849307 0.184279519804056 no 610 0.195588897548046 907 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1362 1611-0397 101 µM 0.857467332119428 0.184284062674738 no 611 0.195593330747254 965 27816 SGTC_579 4491-1009 110 µM 0.85725430453997 0.184344366660817 no 612 0.195652178245272 1160 1271041 SGTC_3333 9141820 12.094 µM 0.857050444182458 0.18440208707903 no 613 0.195708503421064 918 1939433 SGTC_500 h-89 112 µM 0.85652825053013 0.184549990722883 no 614 0.195852826728216 1007 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2418 pentamidine 31.67 µM 0.855807395778186 0.184754283369139 no 615 0.196052161853246 934 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3164 9100705 49.47 µM 0.85561157474905 0.184809803975977 no 616 0.196106332718919 946 17174235 SGTC_49 0717-0965 32.132 µM 0.85347123149628 0.185417325677933 no 617 0.196699017329859 1058 5889349 YGL099W LSG1 SGTC_2526 patulin 37.61 µM 0.852984113516954 0.185555763751074 no 618 0.196834057067041 988 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2536 dehydroabietamide 32.04 µM 0.85292210040447 0.185573392370218 no 619 0.196851252482751 988 3983547 SGTC_341 1486-1430 230 µM 0.850641457237837 0.186222438185229 no 620 0.197484276321093 979 2054753 YPL210C SRP72 SGTC_762 1165-0429 115 µM 0.84817666503384 0.186925470358294 no 621 0.198169795381731 967 5967793 SGTC_2287 7945887 168.79 µM 0.848108347405592 0.186944979942841 no 622 0.198188816625446 1008 1245853 SGTC_280 3448-3607 3.04 µM 0.847572674615997 0.187097996622909 no 623 0.198337998799662 986 626179 SGTC_331 k048-0133 24.5 µM 0.847418988532857 0.187141911851342 no 624 0.198380812107073 936 6813582 SGTC_597 k018-0003 82.8 µM 0.846440704529351 0.187421602300277 no 625 0.198653469597332 1073 6786234 SGTC_1575 cyproterone acetate 48 µM 0.846270646877297 0.187470247965471 no 626 0.198700889404343 950 9880 An androgen receptor antagonist and liver toxin. SGTC_1161 k007-0610 110 µM 0.846238131293162 0.187479550065732 no 627 0.198709957005132 1056 5843850 SGTC_2480 5767542 37.17 µM 0.845672909826596 0.187641294926894 no 628 0.198867619828306 997 2867358 SGTC_2328 6201408 200 µM 0.844093492892401 0.18809372075364 no 629 0.199308581806288 908 2890418 SGTC_779 1360-0071 233 µM 0.84292175164528 0.188429802051258 no 630 0.199636103752031 1047 7566 SGTC_1414 3917-0015 5.4 µM 0.841690327158671 0.188783400691151 no 631 0.199980656989469 989 6618702 SGTC_3006 9075424 71.4286 µM 0.841688065254665 0.188784050563917 no 632 0.199981290200237 942 7465181 SGTC_3204 9114183 49.47 µM 0.839695290854266 0.189357134681386 no 633 0.200539627515466 928 17027248 SGTC_2383 9036125 200 µM 0.839093122231949 0.189530517413684 no 634 0.200708527655844 966 79580 SGTC_1128 3448-9350 235 µM 0.837855766961629 0.189887096233335 no 635 0.201055856943258 883 619386 SGTC_2583 asiatic acid 100 µM 0.834060648455865 0.190983336774621 no 636 0.202123404335536 985 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_612 0302-0167 22.4 µM 0.831736529256219 0.191656583687381 no 637 0.202778838442994 1056 235821 SGTC_2133 5320837 200 µM 0.831046120995243 0.191856859678308 no 638 0.202973787601334 934 2841355 SGTC_105 0111-0055 734.78 µM 0.82990593106419 0.192187890259947 no 639 0.203295985635287 891 5179370 SGTC_1280 0880-0253 10.1 µM 0.829592854187694 0.192278846767211 no 640 0.20338450914918 979 6836607 SGTC_2137 5261020 140 µM 0.828220505860118 0.192677858156716 no 641 0.203772816419212 974 763655 SGTC_1059 3448-6867 171 µM 0.827535640186888 0.192877172533254 no 642 0.203966765010447 1026 3934407 SGTC_1067 clotrimazole 1.36 µM 0.82704673701267 0.193019533551517 no 643 0.204105285820914 1019 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1253 0550-0034 176 µM 0.825270879283795 0.193537175347781 no 644 0.204608910370752 947 5969915 SGTC_3022 9087993 49.47 µM 0.823658875662325 0.194007787978496 no 645 0.205066706262995 1022 17173644 SGTC_1837 st055472 66.5 µM 0.822479308842585 0.194352595243374 no 646 0.205402079023431 1017 676091 SGTC_729 4092-0585 94.1 µM 0.81968767689117 0.195170121474193 no 647 0.206197088426623 983 2169061 SGTC_3211 9128781 49.47 µM 0.817532299777908 0.195802748690721 no 648 0.20681214929029 918 17194361 SGTC_1655 st012546 55.1 µM 0.816668512289418 0.196056628870681 no 649 0.207058945194387 964 720985 YLR208W SEC13 SGTC_578 3460-0051 92 µM 0.815939971059661 0.196270913279806 no 650 0.20726723478446 1111 2876744 SGTC_3276 9139060 49.47 µM 0.815180810629484 0.196494354658852 no 651 0.207484410159862 1027 4870619 SGTC_1192 1488-0095 21.4 µM 0.814250542607328 0.196768367687766 no 652 0.207750718118484 969 915875 SGTC_2769 toremifene 3.73 µM 0.812156992366694 0.197385874540596 no 653 0.208350777011111 988 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_501 nsc-95397 161 µM 0.811079504538013 0.197704143186176 no 654 0.208660007490144 1002 262093 SGTC_647 0140-0236 81 µM 0.809463938410326 0.198181930261768 no 655 0.209124168741266 1083 990837 SGTC_1031 k035-0009 16 µM 0.809251061248143 0.198244938429075 no 656 0.209185374848801 1095 5180959 SGTC_1740 st038286 13.222 µM 0.809123405673287 0.198282728195686 no 657 0.209222083237098 1008 716786 SGTC_3232 9132874 49.47 µM 0.806542110819935 0.19904779909711 no 658 0.209965168594972 1010 3784940 SGTC_2892 9047358 58.44 µM 0.804746235492773 0.199581126921213 no 659 0.210483066424375 974 6466771 SGTC_986 1493-0483 84 µM 0.80440679794294 0.199682027509533 no 660 0.210581038232205 1008 40079 SGTC_3248 9135562 49.47 µM 0.803778440901556 0.19986889275742 no 661 0.210762471430561 1041 17650701 SGTC_693 4161-2696 114 µM 0.803136911015416 0.200059783898933 no 662 0.210947802745159 998 805759 SGTC_1664 st014217 9.02 µM 0.800392788343287 0.200877550671956 no 663 0.211741628997132 1137 3982782 SGTC_2165 5727197 32.143 µM 0.800225051989476 0.200927602183927 no 664 0.211790208792277 1036 1361712 SGTC_1990 st072050 59.8 µM 0.799811866449789 0.201050926158998 no 665 0.211909903384932 1071 17233948 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.799757443601019 0.201067173194042 no 666 0.211925671940441 1013 6708760 SGTC_1646 st011709 75.6 µM 0.799369725925169 0.201182942635879 no 667 0.2120380296859 1018 5757843 SGTC_2739 tacrine 100.86 µM 0.797846227080988 0.201638234339949 no 668 0.212479865751717 1044 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1007 4101-0031 70 µM 0.796703139980364 0.201980246402251 no 669 0.212811729952306 1059 1146276 SGTC_97 0535-0701 19.132 µM 0.795875329212599 0.202228144317518 no 670 0.213052251040548 1009 2832013 YGL099W LSG1 SGTC_3223 9129970 49.47 µM 0.795417308304423 0.202365382378319 no 671 0.213185397505884 1074 17248386 SGTC_969 1313-0238 134 µM 0.794113744722076 0.202756277430175 no 672 0.213564608335848 1067 5212874 SGTC_661 1304-0007 33.6 µM 0.793901276776932 0.202820032181998 no 673 0.21362645317371 1007 3117130 SGTC_984 1492-0255 2.91 µM 0.79231541506863 0.203296276131119 no 674 0.214088392801543 996 1585198 SGTC_2303 7774051 200 µM 0.791754390009483 0.203464915053847 no 675 0.214251950756439 1013 2953184 SGTC_310 1273-0058 1.06 µM 0.791399573941332 0.203571612533531 no 676 0.214355429264852 1122 2734232 SGTC_2842 9000675 19.48 µM 0.790890186926025 0.203724849693229 no 677 0.214504037630019 1036 2989072 SGTC_171 k064-0041 9.68 µM 0.789445851783642 0.204159717887191 no 678 0.214925732953212 979 53325 SGTC_1567 st069303 68.4 µM 0.787916729520828 0.204620716220443 no 679 0.215372707435414 1063 5581319 SGTC_1977 st070720 65.3 µM 0.787774923006289 0.204663499272138 no 680 0.21541418590545 998 682188 SGTC_923 1900-2434 73.3 µM 0.787508475337846 0.204743900974992 no 681 0.215492134502774 1027 5910570 SGTC_2767 sibutramine 71.45 µM 0.787219749488578 0.204831046418026 no 682 0.215576618992346 1069 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_107 0358-0022 2.6945 µM 0.78650152019903 0.205047923533293 no 683 0.215786864407531 977 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2057 5236571 38.335 µM 0.78611108567824 0.205165876709978 no 684 0.215901205147576 1070 54684039 YBR257W POP4 SGTC_946 3434-1334 87.4 µM 0.78282408170371 0.206160502647195 no 685 0.216865211979409 1039 4047976 SGTC_675 1309-0189 238 µM 0.782417864518888 0.206283619478731 no 686 0.216984519172915 1053 4246530 SGTC_2596 sinensetin 100 µM 0.782089557027527 0.206383155174063 no 687 0.217080971770791 1027 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2294 7971431 200 µM 0.781324880715913 0.206615098720502 no 688 0.217305720044304 988 5741572 SGTC_1258 0671-0043 57.1 µM 0.781312049092627 0.206618992157382 no 689 0.217309492570624 1073 4298767 SGTC_826 1683-5028 118 µM 0.78066028358281 0.206816811337447 no 690 0.217501162852441 1040 722377 SGTC_1694 st024011 44.9 µM 0.779202381612159 0.207259708930035 no 691 0.217930253701182 1119 2787533 SGTC_3170 9103054 49.47 µM 0.779007271653819 0.207319024117003 no 692 0.217987715628178 1033 16432970 SGTC_2246 7293507 91.5585 µM 0.777531900808166 0.207767874972842 no 693 0.218422510479879 1111 887656 SGTC_1094 duloxetine 25.4 µM 0.775100561281175 0.208508810476072 no 694 0.219140119983135 1074 60834 A selective serotonin reuptake inhibitor. SGTC_2050 5263056 171 µM 0.773788164521616 0.208909401817829 no 695 0.219528036337343 1102 763468 YGL055W OLE1 SGTC_344 k064-0035 6.43 µM 0.772731687256101 0.209232206342613 no 696 0.219840594730477 1038 5088750 SGTC_3108 9121785 49.47 µM 0.772377442457637 0.209340510833104 no 697 0.21994545507179 1070 17140271 SGTC_2485 5633444 17.78 µM 0.772372354463228 0.209342066643577 no 698 0.21994696138292 1053 5724239 SGTC_2099 5377090 177.372 µM 0.772124678392775 0.209417809432429 no 699 0.220020293546404 1040 2243829 SGTC_812 4251-0442 148 µM 0.771510813901689 0.209605607232542 no 700 0.220202107575961 1083 5723007 SGTC_2698 st077697 67.5 µM 0.768153711776701 0.210634386477009 no 701 0.221197934864106 1032 3154499 SGTC_3174 9107204 49.47 µM 0.76805517114125 0.210664628806427 no 702 0.221227204136907 1065 3938802 SGTC_1321 1326-2144 215 µM 0.767008090256598 0.210986137463346 no 703 0.22153835270455 1089 3513030 SGTC_200 k038-0079 37.545 µM 0.766154150185148 0.211248554610399 no 704 0.221792292995582 1054 3436683 SGTC_1527 coumarin 137 µM 0.76608560066476 0.21126962827555 no 705 0.221812685105237 1048 323 A hepatotoxic, DNA x-linker. SGTC_1553 gossypol 38.6 µM 0.763998625222103 0.211911800813864 no 706 0.222434030932381 1036 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2647 atorvastatin 60.16 µM 0.763003642888366 0.212218363259251 no 707 0.222730611657269 1056 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1160 4092-0570 10.5 µM 0.76279291130324 0.212283324688773 no 708 0.222793454672234 1071 4994975 SGTC_1860 st056228 74.6 µM 0.761789178649534 0.212592901034174 no 709 0.22309291999114 1096 688679 SGTC_2868 9035608 32.47 µM 0.761602278271131 0.212650574907718 no 710 0.223148707334039 1119 6462614 SGTC_322 k048-0136 19.3 µM 0.758921455808156 0.213478830212027 no 711 0.223949771621447 1085 6823282 SGTC_2449 5812982 45.77 µM 0.758806303158576 0.213514449340006 no 712 0.223984217277959 1053 776185 SGTC_472 calcifediol 10 µM 0.757770220659373 0.213835087107122 no 713 0.224294276387671 1043 5283731 A vitamin D metabolite. SGTC_542 3381-0244 89.3 µM 0.756757544436421 0.214148752095047 no 714 0.224597566248875 1132 1112843 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.756117438715021 0.214347155612027 no 715 0.22478939364181 1146 688751 SGTC_1080 nisoldipine 24.4 µM 0.755936416047524 0.214403283751208 no 716 0.224843659505448 1130 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3218 9131285 49.47 µM 0.75592396038494 0.214407146085469 no 717 0.224847393660571 1117 17156417 SGTC_1039 k821-0043 94 µM 0.755916136834937 0.214409572084302 no 718 0.224849739145851 1113 15992768 SGTC_3103 9120822 49.47 µM 0.75472690575814 0.214778525462825 no 719 0.225206429612158 1145 17141819 SGTC_1546 5-methoxyflavanone 78.7 µM 0.754571784659878 0.214826678239072 no 720 0.225252979274045 1133 147795 SGTC_2757 clomiphene 4.22 µM 0.752915506411158 0.215341211890882 no 721 0.225750344700917 1170 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3300 9124615 50.48 µM 0.75003654288095 0.216237280335276 no 722 0.226616348098337 1112 24824903 SGTC_1912 st060209 90.8 µM 0.749773638710842 0.21631921587532 no 723 0.226695524020261 1083 688787 SGTC_2753 fluvastatin 17.09 µM 0.749286507225285 0.216471080590986 no 724 0.226842269238657 1096 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1459 k035-0031 35.7 µM 0.748997768254638 0.216561124953501 no 725 0.226929275280108 1001 3877128 YMR208W ERG12 SGTC_1856 st057054 55.7 µM 0.748444155167999 0.216733831922516 no 726 0.227096148767553 1140 1266018 SGTC_643 k048-0106 28.4 µM 0.745394232321117 0.217686722957611 no 727 0.228016714794581 1109 6763920 SGTC_2700 st077718 96.8 µM 0.744192315040285 0.218062902380292 no 728 0.228380068307267 1098 904970 SGTC_727 3032-0951 202 µM 0.744066131684935 0.218102417322726 no 729 0.228418233860705 1103 3652836 SGTC_496 calpeptin 138 µM 0.742813013588744 0.218495061411111 no 730 0.228797447765948 1091 73364 A calpain inhibitor. SGTC_1685 st024049 53.0905 µM 0.741989106122865 0.218753441001261 no 731 0.229046968000466 1110 1941139 SGTC_2954 9074818 52.69 µM 0.741643086974206 0.218862005942408 no 732 0.229151805341969 1088 16648742 SGTC_335 4077-0256 27.6 µM 0.740413052732739 0.219248185146529 no 733 0.229524700545611 1165 3121989 SGTC_2507 purpurin 79.67 µM 0.738898373562549 0.219724268612363 no 734 0.229984355019342 1151 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2580 diallyl disulphide 81.36 µM 0.737245489149724 0.220244468382736 no 735 0.230486537467759 1098 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1281 0884-0031 11.8 µM 0.734840445509429 0.221002649420493 no 736 0.231218335862865 1167 1548255 SGTC_1050 3232-1156 69.3 µM 0.733902127059433 0.221298855422406 no 737 0.231504195310205 1088 700529 SGTC_2974 9094440 9.66 µM 0.733414541952315 0.221452864663912 no 738 0.231652816250601 1134 25236134 SGTC_749 1000-0129 128 µM 0.73180205861714 0.221962621848007 no 739 0.232144696194191 1179 708470 SGTC_1611 st001856 99.4 µM 0.731580990759579 0.222032560604814 no 740 0.232212177116427 1122 647478 SGTC_1494 4358-1428 177 µM 0.730449108546151 0.222390848769472 no 741 0.232557854921543 1183 1564571 SGTC_2145 5634607 200 µM 0.729795082420746 0.222598025692762 no 742 0.232757725413998 1115 308662 SGTC_655 k060-0012 42 µM 0.728341830881644 0.223058768216385 no 743 0.233202180845788 1129 5994525 SGTC_3009 9080819 71.4286 µM 0.727671226497378 0.223271561303068 no 744 0.233407433992004 1169 17027216 SGTC_2288 7946289 167.31 µM 0.727459090531373 0.223338899356051 no 745 0.233472383706941 1180 1246052 SGTC_2661 dactinomycin 12.96 µM 0.725606224100834 0.223927543505865 no 746 0.23404010220227 1156 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1222 0366-0074 1.18 µM 0.724534795780777 0.224268331517589 no 747 0.234368736553336 1181 286520 SGTC_2897 9048598 12.99 µM 0.72434118762062 0.224329943646089 no 748 0.234428148337166 1154 6467404 SGTC_2643 anethole 100 µM 0.723051299755456 0.224740671193125 no 749 0.234824183845427 1152 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1777 st045864 34.765 µM 0.720287884063206 0.225622035043411 no 750 0.235673881493103 1173 4691462 SGTC_1953 st076800 12.1 µM 0.720102123922059 0.22568135145891 no 751 0.235731059956989 1110 297591 SGTC_768 0384-0033 77.3 µM 0.717387007099514 0.226549341334998 no 752 0.23656766718866 1141 3965305 YMR134W ERG29 SGTC_1558 st069300 45.6 µM 0.714095055500031 0.22760426152094 no 753 0.23758420160873 1111 24208000 SGTC_3255 9139072 49.47 µM 0.713802136705846 0.22769826243251 no 754 0.237674769122742 1192 17646060 SGTC_3120 9124077 49.47 µM 0.713593567603855 0.227765207904092 no 755 0.237739268112729 1222 18774327 YGL155W CDC43 SGTC_769 0302-0231 76 µM 0.712273129863283 0.228189292408189 no 756 0.238147829849569 1186 571869 YER009W NTF2 SGTC_2252 omeprazole 400 µM 0.712108436514693 0.228242218031084 no 757 0.238198815226347 1108 4594 A proton pump inhibitor. SGTC_400 oxethazaine 37.5 µM 0.709947004381996 0.228937452035681 no 758 0.238868500235536 1119 4621 A local anesthetic. SGTC_1877 wortmannin 25 µM 0.709242583300574 0.229164288620683 no 759 0.239086976062173 1186 312145 A covalent inhibitor of PI 3-kinase. SGTC_379 3970-0972 5.9 µM 0.70921151617729 0.229174295708916 no 760 0.239096614028203 1160 2898042 YBL034C STU1 SGTC_1523 st012844 44.7 µM 0.708687609449787 0.229343089177551 no 761 0.239259177803368 1172 4274103 SGTC_349 k015-0014 24 µM 0.707547113836466 0.229710777542722 no 762 0.239613272554642 1168 2196908 SGTC_1203 3992-3522 103 µM 0.707374327554498 0.229766511499065 no 763 0.239666943220733 1269 5322312 SGTC_3270 9137563 49.47 µM 0.704061182639824 0.230836663284337 no 764 0.240697336265039 1126 17015724 SGTC_2040 5100729 123 µM 0.702904872848602 0.23121080765199 no 765 0.241057517109957 1185 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1185 1319-0113 81.3 µM 0.701918416406446 0.231530260235622 no 766 0.241365021559613 1184 4672763 SGTC_1662 st014054 52 µM 0.699239408281288 0.23239906648053 no 767 0.24220121319083 1199 2838777 SGTC_3039 9090270 49.47 µM 0.699175425829391 0.232419838230708 no 768 0.24222120304428 1187 17173750 SGTC_2336 9001819 198.65 µM 0.698840445089554 0.232528605781408 no 769 0.242325874709674 1234 2989602 SGTC_340 k038-0059 454 µM 0.698587152137622 0.232610868264958 no 770 0.242405037606202 1175 23733424 SGTC_1243 0416-0003 5.65 µM 0.697070371021195 0.23310381481555 no 771 0.242879377722438 1184 2141977 SGTC_1776 st049249 45.9 µM 0.696625415136987 0.233248533286396 no 772 0.243018623159477 1202 1822314 SGTC_1392 3455-1037 33.9 µM 0.695366181331776 0.233658359493089 no 773 0.243412924358209 1202 981132 SGTC_1617 st002906 78 µM 0.693499887973666 0.234266490994192 no 774 0.243997948054665 1201 5150859 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.693283327482054 0.234337113894853 no 775 0.244065881971427 1198 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2466 5983409 37.09 µM 0.693163703005997 0.234376129882376 no 776 0.244103411930226 1158 2879657 SGTC_1919 st067113 52.3 µM 0.692248605370142 0.234674711431605 no 777 0.244390609767297 1189 1268243 SGTC_1163 k060-0048 49.9 µM 0.689235425883256 0.235659348078534 no 778 0.24533756338239 1223 6809982 SGTC_1029 k015-0030 64.7 µM 0.688162164234059 0.236010614476668 no 779 0.245675333651627 1191 2208316 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.686775987881468 0.23646472096009 no 780 0.246111951781978 1170 6857784 SGTC_2019 4016004 108 µM 0.686755920058138 0.23647129863773 no 781 0.246118275804193 1188 45595336 SGTC_1982 st072467 71.9 µM 0.68510082402208 0.237014139866587 no 782 0.246640150156507 1186 3163533 SGTC_2658 polymyxin b sulfate 77.05 µM 0.68425757569558 0.237290973030397 no 783 0.246906265579863 1189 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2351 9026858 72.31 µM 0.684163805505597 0.237321768166282 no 784 0.246935867414296 1169 1409300 SGTC_256 clotrimazole 625 nM 0.683401128078057 0.237572321112604 no 785 0.247176703701443 1200 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1272 0839-0021 27 µM 0.683282273977802 0.237611379844378 no 786 0.247214246449012 1207 5027250 SGTC_3186 9110464 49.47 µM 0.683023478965558 0.237696439203477 no 787 0.2472960032361 1223 17018021 SGTC_2963 9082507 9 µM 0.681959394312438 0.238046352336141 no 788 0.247632313584292 1221 16459611 SGTC_967 1306-0166 352 µM 0.681595798158434 0.238165981823624 no 789 0.247747286306632 1199 4437607 SGTC_2763 lisinopril 49.32 µM 0.681452660730562 0.238213085573404 no 790 0.247792555603597 1189 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1476 4112-3294 3.34 µM 0.680742370729097 0.23844690371596 no 791 0.248017260480264 1250 704369 SGTC_1509 1326-1131 80 µM 0.679441830170718 0.238875350083109 no 792 0.248428976594004 1190 768313 SGTC_2634 4'-methoxyflavone 100 µM 0.679163436508185 0.238967117974845 no 793 0.248517155837035 1209 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_186 3455-3465 67.277 µM 0.677971550829022 0.239360221321032 no 794 0.248894865740343 1178 755278 SGTC_519 k048-0011 62.8 µM 0.677305029746502 0.239580204743864 no 795 0.249106220152182 1222 6836379 SGTC_1702 st027038 51 µM 0.677192757337725 0.239617270796941 no 796 0.249141831223232 1229 5521182 SGTC_2157 5649910 96.377 µM 0.677042238602415 0.23966696855297 no 797 0.24918957768556 1200 2858091 SGTC_456 gingerol 170 µM 0.67700924683581 0.23967786241209 no 798 0.249200043744842 1280 442793 A herb. SGTC_1874 staurosporine 7.6 µM 0.676098131760453 0.239978818753089 no 799 0.249489171372174 1236 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1379 2144-0755 36.5 µM 0.675919460883895 0.240037860849998 no 800 0.249545890582209 1256 5392327 SGTC_934 2950-0684 338 µM 0.672682557255617 0.241108871436915 no 801 0.250574633414808 1238 1121253 SGTC_382 3229-0966 23.2 µM 0.67251988914557 0.241162762728615 no 802 0.250626391323936 1248 5722370 SGTC_1400 3771-8998 51.5 µM 0.671222121240354 0.241592942431615 no 803 0.251039519201616 1185 670767 SGTC_1241 0364-0022 50.8 µM 0.670637648725077 0.241786817386951 no 804 0.251225696187979 1237 4563895 SGTC_1021 4476-0760 85.3 µM 0.670199797829919 0.241932111889925 no 805 0.251365216369409 1214 746768 SGTC_2005 4024620 188 µM 0.670197697403888 0.241932809000132 no 806 0.251365885764035 1246 236743 SGTC_3163 9099914 49.47 µM 0.669106682578549 0.242295053049088 no 807 0.251713713722798 1254 16268368 SGTC_2622 2-methoxyxanthone 59.94 µM 0.66633267828621 0.243217413780803 no 808 0.252599241345779 1267 71034 A hepatoprotective. SGTC_2812 7970281 58.44 µM 0.664389038180592 0.243864806315924 no 809 0.253220673462616 1270 2233435 SGTC_1465 k213-0056 144 µM 0.663507418118637 0.244158764827294 no 810 0.253502815047302 1173 24048857 YMR208W ERG12 SGTC_2453 5731132 22.18 µM 0.662999224087028 0.244328298698698 no 811 0.253665525507492 1296 1362040 SGTC_3079 9117512 49.47 µM 0.662507324814705 0.24449245703617 no 812 0.253823071034084 1263 7185044 SGTC_571 k831-0106 44.2 µM 0.662467483289522 0.244505755689394 no 813 0.253835833728302 1235 4783639 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.662326232826962 0.244552906645513 no 814 0.253881084119362 1254 5379071 SGTC_707 0865-0008 204 µM 0.66221010850252 0.244591673888789 no 815 0.253918288379745 1260 723043 SGTC_1208 2323-2347 50.3 µM 0.66155958775517 0.244808906601779 no 816 0.254126757071957 1246 5412760 SGTC_3047 9092122 49.47 µM 0.661432894832292 0.244851226089908 no 817 0.254167368075627 1216 17173831 SGTC_1016 4226-1401 38 µM 0.661252588666243 0.244911460904467 no 818 0.254225170497947 1242 2901613 SGTC_1051 3253-3903 78 µM 0.661003497543411 0.244994687799658 no 819 0.254305035289985 1227 5509239 SGTC_397 arbidol 50 µM 0.660952469347727 0.245011739334654 no 820 0.254321397818206 1297 131410 A RNA synthesis inhibitor. SGTC_3073 9114972 49.47 µM 0.659176044470944 0.245605745634556 no 821 0.254891364045285 1188 41905075 SGTC_3074 9116018 49.47 µM 0.656803022358477 0.246400449130592 no 822 0.255653790305168 1296 17027303 SGTC_23 0213-0011 39.996 µM 0.65664799174189 0.246452415386993 no 823 0.25570364137186 1285 627608 SGTC_2048 5246248 200 µM 0.65506812745806 0.24698232054188 no 824 0.256211945901814 1250 677046 SGTC_589 1227-0070 34.1 µM 0.653770127302861 0.247418140921098 no 825 0.256629957528154 1262 2841384 SGTC_1635 st007035 42.4 µM 0.65372528380101 0.247433205049767 no 826 0.256644405400009 1285 3716403 SGTC_1328 1441-0025 69.2 µM 0.653496518294578 0.247510061114449 no 827 0.256718116643869 1205 4562601 SGTC_512 prima-1 270 µM 0.653490604433197 0.247512048104569 no 828 0.256720022313637 1280 322968 A re-activator of the apoptotic function of mutant p53. SGTC_195 4234-0266 16.654 µM 0.65341574324902 0.247537201347254 no 829 0.256744146054711 1260 2303354 SGTC_2221 6807166 181.081 µM 0.652554619730141 0.247826635704926 no 830 0.257021724777693 1217 674925 SGTC_1024 4507-0395 26 µM 0.651414175527357 0.248210231126261 no 831 0.257389581207379 1289 4201836 SGTC_2816 7982706 58.44 µM 0.650701518607665 0.248450098317533 no 832 0.257619591353276 1269 2981853 SGTC_1405 3909-7894 12 µM 0.650623284971784 0.248476437841127 no 833 0.25764484777294 1280 7104060 SGTC_2794 7785382 27.27 µM 0.650452992857645 0.24853377654926 no 834 0.257699828175899 1245 2205081 SGTC_835 0312-0010 67.2 µM 0.649666812605901 0.248798581062588 no 835 0.257953732776279 1236 1626196 SGTC_1735 st034310 56.75 µM 0.649536337726274 0.248842542684926 no 836 0.257995883467278 1343 871153 SGTC_2179 6298986 200 µM 0.646106438358918 0.249999679274407 no 837 0.259105213022698 1248 738374 SGTC_1826 st055655 41.6 µM 0.646015052822766 0.250030548787213 no 838 0.259134803465807 1313 676168 SGTC_1252 0493-0875 34.8 µM 0.643476677462826 0.250888805172795 no 839 0.259957421704792 1283 3960963 SGTC_2291 7917025 104.35 µM 0.641242318420442 0.251645558310644 no 840 0.260682629455351 1245 2964612 SGTC_962 1254-0300 21.5 µM 0.640772122412606 0.251804962005383 no 841 0.260835373861858 1265 7340576 SGTC_1231 0242-0792 125 µM 0.640130111892981 0.252022699526669 no 842 0.261044006987379 1272 3707635 SGTC_912 3474-0017 2.18 µM 0.6393477394783 0.252288174943777 no 843 0.261298369220568 1347 3360550 SGTC_1526 st051518 75 µM 0.639322195835094 0.252296844924001 no 844 0.261306676028023 1281 673993 SGTC_2093 5331342 194.4 µM 0.63884546731098 0.252458684133738 no 845 0.261461733306363 1281 33839 SGTC_2686 alizarin 95.37 µM 0.63830826739431 0.252641117633904 no 846 0.261636515669623 1253 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2105 5350118 200 µM 0.635923448801365 0.253451841455289 no 847 0.262413159113195 1292 2133313 SGTC_725 1497-0963 19 µM 0.634035229592295 0.254094713769357 no 848 0.263028915521337 1294 3549977 SGTC_1936 st074407 74.3 µM 0.634011194626602 0.254102902340439 no 849 0.263036758184172 1309 809813 SGTC_2534 helenine 20.12 µM 0.633948913559851 0.254124121776666 no 850 0.263057081191035 1316 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1395 3486-0190 4.35 µM 0.632547313070039 0.25460189899117 no 851 0.263514651201298 1329 6748079 SGTC_1615 st002656 86.5 µM 0.632471672711423 0.254627696631605 no 852 0.263539356489605 1284 1584458 SGTC_520 3584-0023 682 µM 0.631590541667833 0.254928312987958 no 853 0.263827234307345 1270 1340790 SGTC_1521 st012942 49.4 µM 0.631481887875651 0.254965395369493 no 854 0.263862744120317 1353 24207259 SGTC_1946 st076057 65.1 µM 0.630969972515015 0.255140144594823 no 855 0.264030079100527 1196 953009 SGTC_1340 1486-1359 257 µM 0.627610745412075 0.256288414444657 no 856 0.265129483879682 1283 4309068 SGTC_2445 5742597 35.57 µM 0.62661526864595 0.256629210591778 no 857 0.265455728628942 1265 1774255 SGTC_2934 9036370 36.88 µM 0.626414323420296 0.256698031730284 no 858 0.265521608531925 1313 6462800 SGTC_1225 1216-0074 20.6 µM 0.625812484760547 0.256904211154167 no 859 0.265718970977297 1294 4241466 SGTC_1687 st020778 55.3625 µM 0.625707473199846 0.256940195110025 no 860 0.265753415298318 1304 4259299 SGTC_2216 7189485 200 µM 0.624325131803927 0.257414121706354 no 861 0.266207041145555 1312 731273 SGTC_2833 9001315 45.46 µM 0.623763384344176 0.257606842811695 no 862 0.266391494798759 1344 2989378 SGTC_2685 mycophenolic acid 18.85 µM 0.623458587675428 0.257711442056913 no 863 0.266491603942473 1282 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1013 4112-3890 241 µM 0.621167816856861 0.258498287198951 no 864 0.267244606115686 1269 705171 SGTC_1689 st020265 53.493 µM 0.620862741051345 0.258603169938027 no 865 0.267344968930118 1349 5758320 YPR016C TIF6 SGTC_1327 1436-0082 2.18 µM 0.62061994834002 0.258686655966802 no 866 0.267424855647327 1287 15992205 SGTC_1707 st032323 6.317 µM 0.620451034718184 0.25874474636542 no 867 0.267480440836767 1257 3132057 YMR211W DML1 SGTC_3280 9140961 49.47 µM 0.619550688073464 0.259054494794818 no 868 0.267776820346895 1298 4901226 SGTC_1644 st010134 20.9 µM 0.61836892059938 0.259461351933251 no 869 0.26816608998765 1294 3818134 SGTC_1467 k284-1082 293 µM 0.617344998579055 0.259814132942363 no 870 0.268503596052205 1339 3334705 SGTC_1346 1488-2224 62.4 µM 0.615213965563653 0.26054914955162 no 871 0.269206713028843 1317 3722427 SGTC_1483 3453-0561 55.9 µM 0.614222586772358 0.260891451448627 no 872 0.269534124877509 1326 4546991 SGTC_1316 1272-0050 65.9 µM 0.612524178582971 0.26147841257014 no 873 0.270095502987158 1330 7340392 SGTC_1938 st074717 56.4 µM 0.611988232315338 0.261663773477982 no 874 0.270272771665407 1245 17250979 SGTC_1217 1183-1422 255 µM 0.60842569268826 0.262897615205854 no 875 0.271452587713954 1364 2849664 SGTC_2306 7482397 179.52 µM 0.608416233180764 0.262900895345188 no 876 0.271455723857116 1397 891448 SGTC_2159 5658611 73.75 µM 0.607095987603967 0.263358903360452 no 877 0.27189360640436 1337 793844 SGTC_3126 9127922 49.47 µM 0.605773979356172 0.26381793074053 no 878 0.272332425385955 1343 45595682 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.60575113680979 0.263825865707723 no 879 0.27234001068619 1322 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3234 9132280 49.47 µM 0.605727556546019 0.263834057068356 no 880 0.272347841069556 1322 17612295 SGTC_3199 9111318 49.47 µM 0.604914001915508 0.264116750746342 no 881 0.272618069571814 1342 8548020 SGTC_1173 0443-0020 122 µM 0.604031632691241 0.264423530439285 no 882 0.272911305746948 1329 5331295 SGTC_352 k048-0007 5.11 µM 0.602441120115341 0.264976973182642 no 883 0.27344027269766 1303 6811911 SGTC_2215 7188065 200 µM 0.601185030231285 0.265414464113937 no 884 0.273858376964803 1364 940217 SGTC_1482 3346-2049 8.48 µM 0.600995020121213 0.265480675755923 no 885 0.273921651574516 1343 3826804 SGTC_1786 berberine 21.6 µM 0.600232721062916 0.265746393594817 no 886 0.274175574780889 1298 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_525 k781-2675 26.7 µM 0.600223650149856 0.265749556293259 no 887 0.274178597018406 1375 3651118 YDL195W SEC31 SGTC_546 peri-Naphthalide 147 µM 0.599846707629534 0.265880999350142 no 888 0.274304200888309 1321 223824 A penicillin ester. SGTC_499 genistein 192 µM 0.598769331179721 0.266256871227348 no 889 0.274663358217873 1365 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_484 loperamide 105 µM 0.597959900132154 0.266539439947617 no 890 0.274933344981201 1326 3955 An opioid-receptor agonist. SGTC_2359 9039622 200 µM 0.597638869351436 0.266651552330614 no 891 0.275040461416207 1309 6463596 SGTC_1905 st060207 84.5 µM 0.596697121444732 0.266980572933489 no 892 0.27535480740658 1322 1948547 SGTC_936 3005-4620 401 µM 0.596066537599445 0.267200995997293 no 893 0.275565388736014 1437 777207 SGTC_592 k241-0073 46.5 µM 0.595841546670344 0.267279664688486 no 894 0.275640542856252 1383 4230158 SGTC_418 lividomycin a 100 µM 0.593446375796885 0.268117866516982 no 895 0.276441230125304 1343 72394 An antibiotic. SGTC_619 1652-1634 108 µM 0.593108790899014 0.26823611230207 no 896 0.276554173811946 1328 5400454 SGTC_3320 9137005 35.139 µM 0.592307864136929 0.268516757664928 no 897 0.276822225379564 1340 4908713 SGTC_2656 pseudo-anisatin 100 µM 0.592010673032002 0.268620931194438 no 898 0.276921720693559 1354 6708809 A neurotoxin. SGTC_2931 9014674 55.67 µM 0.591486396342593 0.268804753874665 no 899 0.277097283679608 1327 2996810 SGTC_2948 9070189 9.45 µM 0.591378761556567 0.268842500760518 no 900 0.277133333760386 1301 6473636 YDL196W YDL196W SGTC_2718 lomofungin 53.02 µM 0.59110937910655 0.268936983266473 no 901 0.277223567986914 1406 5351222 A RNA synthesis inhibitor. SGTC_1285 0929-0069 65.5 µM 0.591089002526605 0.26894413077372 no 902 0.277230394053052 1364 1206237 SGTC_2199 6590217 200 µM 0.590352426827252 0.269202563962692 no 903 0.277477198913049 1342 703109 SGTC_339 3091-4833 71.4 µM 0.589560965144153 0.269480393092074 no 904 0.277742514089897 1343 3240077 SGTC_3219 9131112 49.47 µM 0.587276757818653 0.270283030189808 no 905 0.27850892409867 1308 17612988 YMR079W SEC14 SGTC_2708 st078559 56 µM 0.586406055159995 0.270589296724312 no 906 0.278801338087224 1293 17250902 SGTC_93 0109-0045 59.227 µM 0.585881502099047 0.270773890017853 no 907 0.278977574400269 1399 88733 SGTC_2436 5633522 8.09 µM 0.58407091325152 0.271411529430664 no 908 0.279586301586117 1373 5724242 SGTC_442 cape 100 µM 0.582512540663142 0.271960943650074 no 909 0.280110748454845 1413 5281787 SGTC_180 1486-1293 102.781 µM 0.579265122974319 0.273107616023592 no 910 0.281205147484699 1469 4140536 SGTC_2872 9044037 25.97 µM 0.57811865307093 0.273513009304241 no 911 0.281592007198561 1391 6465195 SGTC_1318 1280-3875 124 µM 0.577270784705959 0.273813008150708 no 912 0.281878273140728 1365 373245 SGTC_1677 st019204 53.9 µM 0.576653885884685 0.274031385918755 no 913 0.282086644884365 1331 3945625 SGTC_2227 7312221 64.1025 µM 0.576017085192191 0.274256899045517 no 914 0.282301816706473 1389 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3344 9148862 3.898 µM 0.575326809629805 0.274501452936785 no 915 0.282535146585395 1434 4905352 SGTC_2052 5265182 7.135 µM 0.574484118378766 0.274800151123005 no 916 0.282820122293347 1441 1239884 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.574333420374564 0.274853584036062 no 917 0.282871098888612 1372 756377 SGTC_2927 9011802 47.9 µM 0.572045098581803 0.275665581790076 no 918 0.283645710953816 1327 43912568 SGTC_723 4182-0001 115 µM 0.571585424831409 0.275828836491795 no 919 0.283801436028961 1326 744821 YLR208W SEC13 SGTC_1852 st056254 31.4 µM 0.571338487903301 0.275916556595258 no 920 0.283885108500879 1388 442583 SGTC_177 1327-0068 8.361 µM 0.571265341873329 0.275942543096922 no 921 0.283909895675852 1362 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_898 1000-0849 28.3 µM 0.571099881208929 0.276001330542123 no 922 0.283965969559241 1374 6751807 SGTC_2368 9071271 200 µM 0.570932677484715 0.276060743536123 no 923 0.284022639540801 1331 27209959 SGTC_1489 4065-0444 182 µM 0.568222059341925 0.277024790612985 no 924 0.284942097255306 1391 2877968 SGTC_1563 conessine 56.1 µM 0.565232046269107 0.278090113944484 no 925 0.285957971124862 1450 441082 An anti-amoebic, histamine inhibitor. SGTC_789 1309-1135 70.6 µM 0.564825575400704 0.278235091181453 no 926 0.286096204716272 1364 3092424 SGTC_2840 9008771 71.43 µM 0.56304915732395 0.278869123892846 no 927 0.286700705520202 1400 2992978 SGTC_1332 1480-0653 17.5 µM 0.562051173222966 0.279225628921795 no 928 0.287040576963959 1358 5749438 SGTC_688 0527-0193 473 µM 0.562014495726932 0.279238735264949 no 929 0.287053071412052 1412 4007154 SGTC_780 0109-0199 192 µM 0.561766014883394 0.279327535328274 no 930 0.287137724948899 1504 610414 SGTC_3200 9114385 49.47 µM 0.560532124732764 0.279768696071095 no 931 0.287558266995204 1349 17018030 YLR208W SEC13 SGTC_1301 naphtanilide LB 4.81 µM 0.560519694441214 0.279773142073125 no 932 0.287562505044873 1486 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1320 1313-0481 95.3 µM 0.557854445340673 0.280727225302496 no 933 0.288471890436171 1407 6813365 YLR208W SEC13 SGTC_1057 3448-5381 134 µM 0.557156177042342 0.280977445347101 no 934 0.288710364075492 1460 5497911 SGTC_1480 1070-0044 41.2 µM 0.556355173047729 0.281264612747229 no 935 0.288984038437993 1429 3124987 SGTC_3198 9112019 49.47 µM 0.555609047215045 0.281532233220028 no 936 0.28923907263954 1435 45595555 SGTC_832 4083-0019 164 µM 0.555602372356715 0.281534627912981 no 937 0.289241354658579 1529 1990758 SGTC_416 estradiol valerate 100 µM 0.554305263697955 0.282000169030461 no 938 0.28968497428855 1410 13791 A steroid. SGTC_3271 9137798 49.47 µM 0.554005295363606 0.282107882468095 no 939 0.289787610862883 1399 6498326 SGTC_60 0986-0278 202 µM 0.553747044357307 0.282200631800295 no 940 0.28987598718317 1222 3110598 SGTC_2412 st077135 33.4 µM 0.552976759699114 0.282477362153874 no 941 0.290139662077876 1485 13258915 SGTC_1899 st063254 59.6 µM 0.55283417678444 0.28252860041026 no 942 0.290188481729336 1331 3093813 SGTC_55 0767-0285 6.563 µM 0.551500282872035 0.283008161667126 no 943 0.290645386407662 1367 3116166 SGTC_2178 5812956 200 µM 0.551013852996642 0.283183140010209 no 944 0.290812089115378 1403 5403383 SGTC_86 0417-1630 471.922 µM 0.550779339634773 0.283267517594059 no 945 0.290892474349314 1425 3634867 SGTC_2354 9060492 162 µM 0.549048859704334 0.283890514371805 no 946 0.291485959792513 1491 6471895 SGTC_489 paxilline 115 µM 0.547583742239736 0.284418489120151 no 947 0.291988877583901 1351 105008 A toxic potassium channel blocker. SGTC_1103 duloxetine 36.1 µM 0.546943499658808 0.284649356339726 no 948 0.292208774716227 1524 60835 A selective serotonin reuptake inhibitor. SGTC_3209 9113616 49.47 µM 0.546089537313435 0.284957428665358 no 949 0.292502195703303 1485 16649353 SGTC_1572 epiandrosterone 68.9 µM 0.546055812971974 0.284969598198416 no 950 0.292513786178517 1390 441302 A steroid. SGTC_2909 7941780 10.49 µM 0.544404698754803 0.285565710788641 no 951 0.293081506549644 1432 1243215 SGTC_3042 9091578 49.47 µM 0.543586348802273 0.285861384854043 no 952 0.293363077917411 1380 25236497 SGTC_2722 naftopidil 47.16 µM 0.543497564231795 0.285893471928992 no 953 0.29339363374479 1452 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3287 9117173 37.0625 µM 0.543172615113228 0.286010924352645 no 954 0.293505479816434 1391 2789709 SGTC_2146 5545642 200 µM 0.542134284471606 0.286386381200467 no 955 0.293863000995324 1416 825326 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.540339528566693 0.287035909962227 no 956 0.294481451388127 1433 442882 SGTC_2277 7947813 106.88 µM 0.539039839553903 0.287506707319868 no 957 0.294929682616163 1523 1246798 SGTC_1883 5-benzylidenerhodanine 20 µM 0.538354734282565 0.287755025681717 no 958 0.295166085285407 1473 1273210 SGTC_1751 st044839 27.194 µM 0.538102351546058 0.287846528057333 no 959 0.295253194547227 1441 5291326 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.537238628922788 0.288159778110638 no 960 0.295551395723244 1454 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2086 5274770 176.623 µM 0.536374247755967 0.288473427925184 no 961 0.295849962825377 1419 689278 SGTC_1119 parthenolide 318.541 nM 0.535525674867989 0.288781497959359 no 962 0.296143204251019 1531 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3224 9130643 49.47 µM 0.534782435402937 0.289051454412421 no 963 0.296400155097203 1475 17644395 SGTC_2484 5809818 12.04 µM 0.534589955518022 0.289121385528624 no 964 0.296466715407353 1440 2870548 SGTC_2125 5246583 200 µM 0.53413439489783 0.28928692990494 no 965 0.296624277368697 1527 835267 SGTC_1251 0490-5699 265 µM 0.53153071562308 0.290233924454616 no 966 0.297525531099265 1503 3883818 SGTC_2854 9024559 71.43 µM 0.530834047293713 0.290487558514991 no 967 0.297766892050027 1395 3163529 SGTC_12 0849-0099 9.267 µM 0.528451866731642 0.291355615117832 no 968 0.298592873252097 1466 6071388 SGTC_2630 antimycin a 100 µM 0.528397415788319 0.291375470955548 no 969 0.298611765380332 1376 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_449 xestospongin c 11.1929 µM 0.528352079019497 0.291392003740805 no 970 0.298627495697921 1479 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_736 0958-0254 92.6 µM 0.526352503360071 0.292121616267812 no 971 0.299321654942867 1517 6812352 SGTC_2623 humulene 100 µM 0.525723310577652 0.292351374175258 no 972 0.299540232567988 1374 6187145 An anti-inflammatory. SGTC_156 3474-0145 5.642 µM 0.52478854157505 0.292692872276679 no 973 0.299865098957699 1443 2265471 SGTC_1876 myriocin 605 nM 0.524719936075932 0.292717943142326 no 974 0.299888948157242 1536 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_882 0843-0131 351 µM 0.524179307712584 0.292915542673741 no 975 0.300076915803548 1452 5425421 SGTC_2956 9076196 2.52 µM 0.524170385357302 0.292918804311569 no 976 0.300080018407641 1470 16423868 SGTC_1505 k297-0037 20.6 µM 0.523610589008196 0.293123476007175 no 977 0.300274707500646 1419 4089396 SGTC_925 2064-1272 59.6 µM 0.522732279119996 0.293444735621261 no 978 0.300580286014863 1427 6815817 SGTC_1909 st060837 51.5 µM 0.522458519875877 0.293544901935554 no 979 0.300675560070789 1412 678937 SGTC_810 3825-7150 143 µM 0.521575526835708 0.293868089859117 no 980 0.30098295332167 1565 22330411 YGL099W LSG1 SGTC_2828 7998861 71.43 µM 0.521009417365612 0.294075380467738 no 981 0.301180105519033 1471 2988188 SGTC_1503 4585-0012 61.3 µM 0.51927639292284 0.294710376578882 no 982 0.301784006622504 1512 2922052 SGTC_1996 st072960 66.8 µM 0.519008386784292 0.294808632923645 no 983 0.30187744638146 1448 1719405 SGTC_2875 9039966 71.43 µM 0.51867878866664 0.294929490807289 no 984 0.301992377871981 1560 6463691 SGTC_590 k048-0076 22.4 µM 0.518237147613388 0.295091468664948 no 985 0.302146409750432 1509 6832814 SGTC_2332 7982454 138.89 µM 0.518090179636075 0.295145380251808 no 986 0.302197675834109 1446 2981748 SGTC_2544 sphondin 68.51 µM 0.517740972326526 0.29527349654922 no 987 0.302319503679784 1505 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_57 miconazole 162.5 nM 0.517704069883462 0.295287036719699 no 988 0.302332379110748 1389 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_701 4424-0219 185 µM 0.51726938285019 0.295446552718428 no 989 0.302484061913054 1537 2911779 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.516604559144722 0.295690598025603 no 990 0.302716116222859 1443 2724 A muscle relaxant with antifungal properties. SGTC_3172 9105863 49.47 µM 0.515377674006516 0.29614120944562 no 991 0.303144565275087 1475 2348785 SGTC_1475 4092-1048 11.7 µM 0.515307770379661 0.296166893194098 no 992 0.303168984969144 1440 2881759 SGTC_2085 5307070 144.047 µM 0.514264039962902 0.296550498490356 no 993 0.303533699770844 1408 2840351 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.514031785874203 0.296635890469245 no 994 0.303614883870362 1453 140250 A respiratory chain inhibitor. SGTC_3034 9090421 49.47 µM 0.513030110499097 0.297004301609664 no 995 0.303965129136988 1439 17173761 SGTC_2680 butyl paraben 22.24 µM 0.51255686962989 0.297178429975965 no 996 0.304130664918558 1480 7184 An antifungal and steroid mimetic. SGTC_225 nsc-122657 1.016 µM 0.512556376976947 0.297178611271292 no 997 0.304130837265453 1467 275685 SGTC_650 1328-0195 38 µM 0.510105311327294 0.298081223801787 no 998 0.304988842185546 1463 2780821 SGTC_872 0588-0139 234 µM 0.509771518376501 0.298204240667986 no 999 0.305105770817202 1456 2047100 SGTC_3293 9120939 62.045 µM 0.504275807956309 0.300232958372405 no 1000 0.307033787595701 1522 934087 SGTC_157 1348-1695 65.819 µM 0.504065769551205 0.300310616789718 no 1001 0.307107580145018 1455 5380510 SGTC_407 eburnamonine 100 µM 0.501097104552232 0.301409203767199 no 1002 0.308151392251232 1440 3195 SGTC_2796 7949634 45.45 µM 0.499553606757629 0.301981105878148 no 1003 0.308694715843556 1447 2971588 SGTC_2589 lobaric acid 100 µM 0.499447276110067 0.302020521815305 no 1004 0.308732160524789 1451 73157 A novel microtubule depolymerizer. SGTC_581 0958-0271 211 µM 0.498600623084697 0.302334451860797 no 1005 0.309030383054752 1449 4591145 SGTC_2995 9067767 71.4286 µM 0.498085772857559 0.302525424457558 no 1006 0.309211793936649 1497 11673567 SGTC_1972 st070201 17.4 µM 0.497158288569136 0.302869591143101 no 1007 0.309538716538645 1571 2829099 SGTC_2104 5389443 200 µM 0.495964373738127 0.303312881533159 no 1008 0.309959773365338 1571 2244536 SGTC_2079 5212404 121 µM 0.493332139117463 0.304291230688357 no 1009 0.310888961498703 1580 758462 SGTC_2524 avocatin b 10.57 µM 0.492797903704912 0.304489966777672 no 1010 0.311077696040954 1536 6710748 SGTC_673 1082-0474 110 µM 0.492355108621353 0.304654730738196 no 1011 0.311234164234171 1469 3098046 SGTC_1753 st043925 64 µM 0.492281302898663 0.304682197687351 no 1012 0.311260247895891 1526 670181 SGTC_330 1488-0319 80.1 µM 0.491297014594672 0.305048607784584 no 1013 0.311608195530733 1507 6846614 SGTC_601 0986-0029 62.9 µM 0.490915232956983 0.305190782051558 no 1014 0.311743201320659 1493 24747981 SGTC_737 1950-0117 57.9 µM 0.490832817885364 0.305221477021031 no 1015 0.311772348295849 1531 5393513 SGTC_689 0833-0039 98 µM 0.487471802750188 0.306474430878895 no 1016 0.312962010219867 1558 5374726 SGTC_3021 9087658 49.47 µM 0.486706401792927 0.306760082206242 no 1017 0.313233203933251 1506 25237042 SGTC_1813 st051246 8.6015 µM 0.484774541156489 0.307481583699178 no 1018 0.313918141933095 1559 5291959 SGTC_2898 9056270 58.44 µM 0.484714155286954 0.307504148336349 no 1019 0.313939561997132 1490 19154699 SGTC_3297 9117502 71.43 µM 0.483949293714373 0.307790020341947 no 1020 0.31421092779139 1500 7453720 SGTC_2670 beta-carotene 100 µM 0.483666883165948 0.307895602641811 no 1021 0.314311149837823 1478 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2223 6903751 107.57 µM 0.483276583598866 0.308041546622591 no 1022 0.31444968214572 1508 5598863 SGTC_78 0336-0123 156.75 µM 0.482367122792985 0.308381737357421 no 1023 0.314772586083358 1457 6765896 SGTC_2543 pimpinellin 60.67 µM 0.481771596729744 0.308604587618126 no 1024 0.314984104310786 1447 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_950 1165-0508 94.1 µM 0.479876838683996 0.309314088888745 no 1025 0.315657485664543 1476 6148369 SGTC_2616 abietic acid 100 µM 0.479041195046256 0.309627225952434 no 1026 0.315954661268004 1551 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3060 1327-0027 12.5 µM 0.47827945230915 0.309912790906714 no 1027 0.316225659549295 1541 16000455 YPR107C YTH1 SGTC_1828 st055811 49 µM 0.476574524058261 0.310552356319335 no 1028 0.316832564030153 1553 5877589 SGTC_1298 1079-1278 263 µM 0.476434131515365 0.310605046981604 no 1029 0.316882561662731 1524 2840950 SGTC_3214 9129694 49.47 µM 0.475297449146386 0.311031797739107 no 1030 0.317287488497466 1618 17158655 SGTC_3134 9127454 49.47 µM 0.47355872840177 0.311685066715456 no 1031 0.317907306122158 1571 24262820 SGTC_106 0092-0003 11.579 µM 0.473484767951287 0.311712868165365 no 1032 0.317933682808873 1602 1072148 SGTC_202 3594-0513 34.79 µM 0.472939595185238 0.311917829620718 no 1033 0.318128137526004 1523 708429 SGTC_2719 novobiocin 32.65 µM 0.472532850579712 0.31207078600576 no 1034 0.318273249717378 1609 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3127 9126946 49.47 µM 0.471982635619279 0.312277746009797 no 1035 0.318469591476159 1460 27243249 SGTC_2692 st077426 47.7 µM 0.469424323808104 0.313240816721616 no 1036 0.319383182709189 1593 25238571 SGTC_1345 1488-0192 31.4 µM 0.467334374728056 0.314028520155486 no 1037 0.32013033325474 1591 658348 SGTC_474 dl-dihydrosphingosine 5 µM 0.46688517898466 0.314197933229082 no 1038 0.320291014801416 1566 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2034 5197015 53.07 µM 0.46617537597295 0.314465713501603 no 1039 0.32054498671481 1616 780676 SGTC_1758 st042942 75.2445 µM 0.465722439662676 0.314636639290457 no 1040 0.320707094067701 1510 669317 SGTC_2820 7989630 71.43 µM 0.465502439409661 0.314719675713179 no 1041 0.320785845202655 1535 2984098 SGTC_2309 7664088 163.95 µM 0.464806239221061 0.314982509743412 no 1042 0.321035109661745 1614 704922 SGTC_671 0560-0003 407 µM 0.463554395280922 0.315455349727403 no 1043 0.321483517256068 1570 3238678 SGTC_2014 4013930 200 µM 0.46347124189096 0.3154867687107 no 1044 0.321513311832384 1510 64556 SGTC_2915 7971052 15.16 µM 0.462858623020801 0.315718283987615 no 1045 0.321732853835968 1443 5741558 SGTC_2986 9022445 71.43 µM 0.461628617883846 0.31618333452017 no 1046 0.322173834249035 1640 6459286 SGTC_1427 4048-4900 550 nM 0.4613257974239 0.316297872047905 no 1047 0.322282439629011 1623 24132586 SGTC_1081 sertraline 6 µM 0.460837826252154 0.316482477280704 no 1048 0.322457480513134 1620 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1153 4055-0057 267 µM 0.460011328313623 0.31679525547998 no 1049 0.322754044639168 1504 882706 SGTC_3226 9131256 49.47 µM 0.459314579738429 0.317059033377449 no 1050 0.323004139691922 1463 17178073 SGTC_191 3914-0123 66.505 µM 0.458960462201479 0.317193132278564 no 1051 0.323131279421482 1474 3144412 SGTC_1717 st033143 58.0435 µM 0.458501491548549 0.317366973172401 no 1052 0.323296095582375 1652 674616 SGTC_2902 5787006 60.46 µM 0.458295808381723 0.317444891330149 no 1053 0.323369967574854 1514 591003 SGTC_2858 9025781 8.96 µM 0.458251034376173 0.317461853965606 no 1054 0.32338604927422 1566 4894980 YPL153C RAD53 SGTC_620 0109-0052 432 µM 0.457676522410164 0.31767954187259 no 1055 0.323592428828587 1622 493037 SGTC_2624 nerol 100 µM 0.456102636712932 0.318276224506177 no 1056 0.324158087107413 1630 637566 A natural product oil. SGTC_3029 9088683 49.47 µM 0.455386884070714 0.318547732765726 no 1057 0.324415464752401 1553 25236615 SGTC_755 1995-0008 37.3 µM 0.454705856892236 0.318806159019321 no 1058 0.324660433359205 1547 689533 SGTC_2059 5238311 157 µM 0.454289835906463 0.318964067961789 no 1059 0.324810115355721 1520 703021 SGTC_2190 6049624 200 µM 0.45162764102344 0.319975333389819 no 1060 0.325768626920806 1569 2265554 SGTC_162 k030-0015 37.8 µM 0.451491738956168 0.320026993346122 no 1061 0.325817588844185 1695 1809920 YMR134W ERG29 SGTC_1186 1319-0216 26 µM 0.451161368232268 0.320152590514168 no 1062 0.32593662521266 1689 4565136 SGTC_1084 voriconazole 435 nM 0.449694672138654 0.320710433648454 no 1063 0.326465306775248 1587 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3249 9135183 49.47 µM 0.448355542160533 0.32122011216734 no 1064 0.326948310828641 1588 4902779 SGTC_1742 st038235 28.8875 µM 0.448206736118152 0.321276769191273 no 1065 0.327002000852305 1574 564103 YBR002C RER2 SGTC_1190 1486-1332 13 µM 0.447810952503823 0.321427481711995 no 1066 0.327144819143704 1515 4150046 SGTC_2162 5663267 200 µM 0.443751841579274 0.322974865350546 no 1067 0.328611004973617 1654 6456493 SGTC_1971 st069429 63.5 µM 0.442469513477671 0.323464344030403 no 1068 0.3290747432853 1625 1246522 YGL099W LSG1 SGTC_3334 9142812 21.919 µM 0.44203138532467 0.323631652445284 no 1069 0.329233247341587 1597 45283678 SGTC_1369 1866-0067 208 µM 0.441537553947315 0.323820275046514 no 1070 0.329411940264345 1671 3531355 SGTC_2167 5876490 200 µM 0.441399469952877 0.323873025363182 no 1071 0.329461912941441 1733 686534 SGTC_1556 plumbagin 1.48 µM 0.441076887294879 0.323996270934068 no 1072 0.329578667659273 1537 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1980 st071811 45.7 µM 0.439734082616764 0.32450950859688 no 1073 0.330064857253594 1615 4974850 SGTC_926 2268-1401 59.4 µM 0.439366964675041 0.324649884008244 no 1074 0.330197829747536 1544 2931578 SGTC_3055 9094636 49.47 µM 0.439039569063201 0.324775091750821 no 1075 0.330316432651327 1612 25236176 SGTC_3335 9143315 29.6265 µM 0.438446677277306 0.325001885074997 no 1076 0.330531258047509 1552 4899691 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.43769697737135 0.325288753593269 no 1077 0.330802980455412 1648 688761 SGTC_1531 st059297 52.4 µM 0.437569057447798 0.325337711791218 no 1078 0.330849352862531 1583 7566702 SGTC_426 0988-0037 14.6 µM 0.435707526908675 0.326050507486525 no 1079 0.331524471982728 1615 5383008 SGTC_1047 2043-3044 82 µM 0.433896680872691 0.326744506102428 no 1080 0.332181735059411 1515 669592 SGTC_1624 st003710 6.25 µM 0.433127303344242 0.327039548306975 no 1081 0.332461144128768 1662 24207033 SGTC_2270 7924575 90.91 µM 0.433101912390797 0.32704928711725 no 1082 0.332470366759097 1708 1262135 SGTC_759 3486-0358 89.3 µM 0.432710240345703 0.327199529545544 no 1083 0.332612644703026 1738 875103 SGTC_3099 9120367 49.47 µM 0.431970381005533 0.327483410376519 no 1084 0.332881470201195 1576 24824940 SGTC_2563 tomatine 8.54 µM 0.430974809321074 0.327865564378918 no 1085 0.333243343541669 1823 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1422 4031-0024 15.5 µM 0.429533407550195 0.328419171430511 no 1086 0.333767543634726 1583 782427 SGTC_1861 st057647 17.4 µM 0.429355424968642 0.328487556341899 no 1087 0.333832293777233 1707 688668 SGTC_2231 micatex 6.853 µM 0.429234442709862 0.328534043727452 no 1088 0.333876310001944 1609 20737 An antifungal of unknown mechanism. SGTC_348 k064-0012 10.7 µM 0.428358089230954 0.328870861416881 no 1089 0.334195216466779 1548 5066323 SGTC_896 0964-0007 44.5 µM 0.427994434366526 0.329010669355249 no 1090 0.334327586230918 1618 6756758 SGTC_1976 st070609 63.5 µM 0.426704296304443 0.329506858740115 no 1091 0.334797360446351 1551 682556 SGTC_2582 agaric acid 100 µM 0.426491091377214 0.329588886672795 no 1092 0.334875019059946 1514 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1014 4130-3005 69.3 µM 0.425098279660285 0.33012495517415 no 1093 0.335382515981213 1564 743608 SGTC_2459 5811157 9.22 µM 0.425048165698782 0.33014424965793 no 1094 0.335400781544261 1558 2870684 YBR192W RIM2 SGTC_2302 7771753 200 µM 0.425033353638099 0.33014995256767 no 1095 0.335406180326426 1536 2203047 SGTC_2134 5324836 1.464 µM 0.424737559984258 0.330263846705133 no 1096 0.335513999955947 1634 699272 SGTC_1522 st012842 45.6 µM 0.424365336823925 0.330407192060039 no 1097 0.335649698123578 1493 3491067 YOR116C RPO31 SGTC_2926 9010726 65.15 µM 0.422244937807185 0.331224244519101 no 1098 0.336423122006241 1545 2994293 SGTC_1398 3558-0053 112 µM 0.42073807437225 0.331805372650758 no 1099 0.336973177636028 1569 4532369 SGTC_2343 7990716 14.84 µM 0.420474085115889 0.331907222925842 no 1100 0.33706957849711 1630 6456862 SGTC_289 k017-0060 526 µM 0.420400754166545 0.331935517105582 no 1101 0.337096358632687 1582 5512909 SGTC_374 0880-0231 82.3 µM 0.419793669389013 0.332169792871656 no 1102 0.337318094983739 1625 6833587 SGTC_42 0133-0086 60.653 µM 0.415679358567404 0.333759242322668 no 1103 0.338822323762576 1512 162923 Model of phenazepam hydroxylation. SGTC_3046 9092212 49.47 µM 0.415075017429941 0.333992965038449 no 1104 0.339043493662848 1623 25236637 SGTC_1581 himbacine 57.9 µM 0.414858384347872 0.334076761339284 no 1105 0.339122788089164 1583 5281825 An alkaloid muscarinic receptor antagonist. SGTC_457 grayanotoxin iii 135 µM 0.414831722392076 0.334087075078593 no 1106 0.339132547684425 1578 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1680 diphenhydramine 100 µM 0.413985431985145 0.334414513682067 no 1107 0.33944238791487 1596 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_295 k015-0027 31 µM 0.413815076783671 0.334480441134023 no 1108 0.339504770767074 1592 3887424 SGTC_134 0269-0018 6.916 µM 0.411703017614913 0.335298231299591 no 1109 0.34027855646332 1546 4378915 SGTC_1167 k781-0610 148 µM 0.411696622897097 0.335300708524926 no 1110 0.340280900291118 1622 4525169 SGTC_1669 st015249 58.4 µM 0.410882813158074 0.335616025593765 no 1111 0.340579232729757 1704 722793 SGTC_364 0083-0097 67.7 µM 0.41064208509373 0.335709319802325 no 1112 0.340667499746603 1633 5207356 SGTC_2893 9048488 25.97 µM 0.409776737165942 0.336044769160355 no 1113 0.340984866233148 1545 6467338 SGTC_144 4161-2749 112.381 µM 0.407611237465048 0.3368847901639 no 1114 0.341779556421835 1537 797501 YMR168C CEP3 SGTC_2464 5717415 7.67 µM 0.40758327547645 0.336895642258639 no 1115 0.341789822445229 1526 5285744 SGTC_1832 st054113 55 µM 0.40713386459344 0.337070077999738 no 1116 0.341954836150664 1660 1251267 SGTC_585 0kpi-0023 191 µM 0.406278132287136 0.33740232146226 no 1117 0.342269125531871 1713 64601 SGTC_3028 9087778 49.47 µM 0.405557297133396 0.33768228867288 no 1118 0.342533955324778 1539 17217395 SGTC_2598 perillyl alcohol 100 µM 0.404070263048742 0.338260125782082 no 1119 0.343080525746834 1667 10819 An apoptosis inducer. SGTC_1673 st016611 27.3 µM 0.403940099651629 0.338310723309036 no 1120 0.343128383921132 1706 5226799 SGTC_13 0199-0087 65 µM 0.403338698272859 0.338544539852219 no 1121 0.343349538439454 1660 4589825 SGTC_1026 k007-1105 30.6 µM 0.403210036900367 0.338594569701887 no 1122 0.343396858309459 1627 7066794 SGTC_700 3453-2283 142 µM 0.402503300794989 0.338869434126103 no 1123 0.343656829816847 1702 565664 SGTC_2184 6075246 200 µM 0.401952615383051 0.339083666671948 no 1124 0.343859449653399 1655 2267320 SGTC_2344 7990960 76.95 µM 0.401759172254433 0.339158933996551 no 1125 0.343930635993401 1630 140813 SGTC_2533 agelasine 13.65 µM 0.401122983241636 0.339406515805353 no 1126 0.344164790151167 1784 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1461 k072-0203 53.8 µM 0.400983209686991 0.339460919923159 no 1127 0.344216242870732 1576 5418714 SGTC_1262 0737-0114 49.6 µM 0.399895857052975 0.339884264817572 no 1128 0.344616611926164 1713 765919 SGTC_3302 9125395 16.351 µM 0.399460428807591 0.340053849130789 no 1129 0.344776987783725 1657 17599668 SGTC_224 benfluorex 43.875 µM 0.39871743920869 0.340343292720376 no 1130 0.345050708281508 1722 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1485 3909-9022 254 µM 0.395569948665191 0.3415704901901 no 1131 0.346211155013524 1630 714516 SGTC_3102 9121669 49.47 µM 0.395448674907059 0.341617808104824 no 1132 0.346255896362739 1670 41905072 SGTC_3150 9097574 49.47 µM 0.395354980604108 0.341654366926804 no 1133 0.346290464333411 1762 17217476 SGTC_1904 st060225 78 µM 0.392488669121756 0.34277349675597 no 1134 0.347348590928055 1613 66595 SGTC_3100 9120536 49.47 µM 0.39114177743898 0.343299858146821 no 1135 0.347846220803009 1717 16421196 SGTC_1630 st005209 31.3 µM 0.390805102099681 0.34343147744901 no 1136 0.347970651688933 1723 3367314 SGTC_790 1575-0012 79.1 µM 0.390770276003358 0.343445093389672 no 1137 0.347983523901943 1720 378741 YLR208W SEC13 SGTC_3125 9127534 49.47 µM 0.389660426281804 0.343879117077311 no 1138 0.348393831579901 1616 1639235 SGTC_1425 4048-4433 7.33 µM 0.389223430187912 0.344050067581597 no 1139 0.348555436276521 1702 23734946 SGTC_361 000s-0510 1.45 µM 0.389029196384704 0.344126061028932 no 1140 0.348627274337027 1639 660 SGTC_1767 st044992 70.3 µM 0.388566802230896 0.344306996811764 no 1141 0.348798314293232 1574 9600693 SGTC_3315 9136395 68.55 µM 0.386039287621278 0.345296647379244 no 1142 0.349733786230212 1777 16876844 SGTC_3007 9078383 71.4286 µM 0.381703832118009 0.346996661437606 no 1143 0.35134052865755 1643 6496995 SGTC_193 1273-0060 1.558 µM 0.381611973701689 0.347032714343107 no 1144 0.351374600745969 1682 2847393 YHR072W ERG7 SGTC_90 0870-0863 4.608 µM 0.380656678408096 0.34740773393407 no 1145 0.351729009261931 1629 1738164 SGTC_1594 piperine 70.1 µM 0.380244250915939 0.347569686502491 no 1146 0.351882057108693 1614 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2147 5545932 89.7195 µM 0.378327824900873 0.348322595821208 no 1147 0.352593538786992 1668 797404 SGTC_1964 st076914 61 µM 0.377553795927805 0.348626859544389 no 1148 0.35288104691268 1653 24208661 SGTC_2195 6536160 144.242 µM 0.37719021806465 0.348769812315832 no 1149 0.353016124606717 1606 3834386 SGTC_3048 9093155 49.47 µM 0.376949131360814 0.348864615440983 no 1150 0.353105704181203 1724 25236002 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.376549684121167 0.349021711841018 no 1151 0.353254143031882 1769 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2026 5148700 152 µM 0.37628891617326 0.349124281791748 no 1152 0.353351059227558 1652 79838 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.375944669557692 0.349259703956738 no 1153 0.353479015405805 1749 688662 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.374715072660083 0.349743568083363 no 1154 0.353936190669125 1607 5355888 SGTC_782 0083-0095 30.5 µM 0.374635682207327 0.349774817771883 no 1155 0.353965716005827 1659 3591729 An indicator and reagent. SGTC_2602 kawain 100 µM 0.374280337808163 0.349914700986873 no 1156 0.354097879469727 1660 5369129 SGTC_1428 4049-0204 61.7 µM 0.371750553747011 0.350911151746881 no 1157 0.355039290835915 1760 X1428 SGTC_282 k297-0036 65.7 µM 0.370077111519603 0.351570864445457 no 1158 0.355662517842267 1718 5061378 SGTC_1926 methyl fluorone black 53.6 µM 0.369163893607611 0.351931066529709 no 1159 0.356002783380581 1611 72721 Reacts with homocysteine. SGTC_3024 9090631 49.47 µM 0.367850303069059 0.352449421318437 no 1160 0.356492429144989 1808 25236383 SGTC_894 0960-0238 55.9 µM 0.366041061859435 0.353163813073813 no 1161 0.3571672178397 1714 6741907 YDL195W SEC31 SGTC_1610 st001799 48.1 µM 0.365927261800597 0.353208765170656 no 1162 0.357209676559356 1612 621897 SGTC_3156 9099931 49.47 µM 0.365263133969864 0.353471142767297 no 1163 0.357457497426093 1697 18111053 SGTC_1263 0774-1208 64.8 µM 0.365252051281216 0.353475521806484 no 1164 0.357461633467803 1814 906585 SGTC_2365 9042475 200 µM 0.364951752892202 0.353594184366945 no 1165 0.357573710718788 1652 6464479 SGTC_3115 9123671 49.47 µM 0.364764807670698 0.353668062741473 no 1166 0.357643488547843 1732 3286988 SGTC_236 1509-0011 5.31 µM 0.36437711056402 0.353821293273989 no 1167 0.357788212746235 1716 3107280 SGTC_128 0906-2981 13.371 µM 0.36415132858155 0.353910540586077 no 1168 0.357872504758636 1760 6740226 SGTC_2317 5986382 200 µM 0.363824611256488 0.35403969992649 no 1169 0.357994491601008 1795 877883 SGTC_1782 st039423 80.636 µM 0.363148550448286 0.354307016603296 no 1170 0.358246959277846 1619 2068169 SGTC_1807 st050092 58.9 µM 0.362831647827642 0.354432345670149 no 1171 0.358365324517271 1667 5008496 SGTC_1795 st049545 62.3 µM 0.362066544962674 0.354734994511949 no 1172 0.358651151611016 1812 5291882 SGTC_1065 prochlorperazine maleate 2.48 µM 0.362008745067683 0.354757861925685 no 1173 0.358672747712194 1691 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3014 9081533 49.47 µM 0.360981989152442 0.355164165256189 no 1174 0.359056455576239 1794 21367265 SGTC_1716 st033144 30.6155 µM 0.360765962515649 0.355249671355692 no 1175 0.359137204785567 1808 674617 SGTC_1690 st023502 41.2 µM 0.360059153009076 0.35552948649182 no 1176 0.359401449080088 1787 24207482 SGTC_1979 st071809 45.3 µM 0.359737989329819 0.355656656052761 no 1177 0.35952153996972 1749 4976333 SGTC_91 0417-1751 58.384 µM 0.358364010798481 0.356200884651122 no 1178 0.360035460393375 1700 6795624 SGTC_3201 9113999 49.47 µM 0.357650322394431 0.356483690114915 no 1179 0.360302507037655 1756 16649224 SGTC_2681 menadione 3.18 µM 0.357254878489915 0.356640422321366 no 1180 0.360450502886219 1700 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_670 4204-0025 119 µM 0.357061285296356 0.356717160840604 no 1181 0.360522963237595 1752 719039 SGTC_2937 9044753 11.33 µM 0.355489346713948 0.357340476979423 no 1182 0.361111512263051 1655 6465530 YGL099W LSG1 SGTC_713 1488-1073 324 µM 0.355429256326995 0.357364312009677 no 1183 0.361134017222099 1773 3312542 SGTC_819 1013-0258 27.7 µM 0.354272436441622 0.357823276424077 no 1184 0.361567361234165 1684 5753198 SGTC_2846 9008642 19.48 µM 0.353944168134863 0.357953553256979 no 1185 0.361690362715713 1670 2992898 SGTC_189 3970-0742 2.116 µM 0.353712160425925 0.358045638008712 no 1186 0.361777304163593 1809 2891807 SGTC_2525 harmine 47.85 µM 0.353670639148826 0.358062118834733 no 1187 0.361792864399202 1773 5280953 A monoamine oxidase inhibitor SGTC_1940 st075990 51.1 µM 0.350469236351621 0.35933362941515 no 1188 0.362993286877436 1764 1084979 SGTC_2913 7966556 36.57 µM 0.349598808038097 0.359679610210062 no 1189 0.363319902801243 1798 2976516 SGTC_112 phenothiazine 287.218 µM 0.34959700767763 0.359680325942747 no 1190 0.363320578464155 1852 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_665 3914-0008 307 µM 0.349158697990206 0.359854590448032 no 1191 0.36348508572814 1650 1069549 SGTC_92 0063-0024 660.874 µM 0.349104923327866 0.359875972349998 no 1192 0.363505270275956 1758 3594437 SGTC_850 0388-0143 75.9 µM 0.348681505885687 0.360044347071806 no 1193 0.363664215044781 1686 67273 SGTC_104 0074-0074 590.992 µM 0.347928534002722 0.36034383834808 no 1194 0.363946927731218 1784 3943124 SGTC_3105 9121040 49.47 µM 0.347131550400832 0.360660928468243 no 1195 0.36424624585957 1754 41448907 SGTC_990 3985-0011 41.3 µM 0.345834344071293 0.36117724343965 no 1196 0.364733606528636 1706 5399565 YGL099W LSG1 SGTC_2151 5563267 85.4165 µM 0.343616895120605 0.362060419484904 no 1197 0.365567208555679 1712 5310824 SGTC_451 chloral hydrate 100 µM 0.341877344732899 0.362753770548402 no 1198 0.366221599876477 1756 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3067 9117431 49.47 µM 0.341502575766956 0.362903205219213 no 1199 0.366362633057973 1702 17150885 SGTC_875 0709-0210 25.7 µM 0.340453106414427 0.363321779681032 no 1200 0.366757665707708 1814 6251364 SGTC_905 2-aminofluorene 215 µM 0.338913869302134 0.363935990245914 no 1201 0.367337307976056 1691 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1393 3470-5649 58.2 µM 0.338042872509989 0.364283704118388 no 1202 0.367665439963737 1704 4108395 SGTC_510 ag-490 170 µM 0.336924206843799 0.364730454679766 no 1203 0.368087018352299 1817 5328779 SGTC_1330 1469-0054 61.8 µM 0.336772888642029 0.364790899271127 no 1204 0.36814405607838 1867 7102664 SGTC_806 3966-4455 5.86 µM 0.335873773144574 0.36515012340739 no 1205 0.368483027650206 1660 714982 SGTC_1529 apigenin 74 µM 0.335606017498427 0.365257122863187 no 1206 0.368583992821831 1838 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_409 arachidonic acid 100 µM 0.333406925950028 0.3661363113366 no 1207 0.369413567903207 1733 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3086 9117350 49.47 µM 0.333264530575152 0.366193264760091 no 1208 0.369467305486446 1705 2679265 SGTC_1271 0832-2808 169 µM 0.332982973578297 0.366305886889176 no 1209 0.369573567795323 1858 3663794 SGTC_2472 5377652 49.4 µM 0.332935963390695 0.366324691974584 no 1210 0.369591310861445 1707 1610903 SGTC_2904 7225135 42.03 µM 0.332806818490561 0.366376354362384 no 1211 0.369640055480626 1807 4446116 SGTC_2649 anisomycin 9.56 µM 0.331836784880262 0.366764478414426 no 1212 0.370006253148097 1739 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2395 5646831 180.19 µM 0.330993079419522 0.367102167616663 no 1213 0.37032485651502 1788 6808628 SGTC_2259 7964009 200 µM 0.330931449553918 0.36712683871837 no 1214 0.370348132916624 1778 313134 SGTC_1266 0828-0227 32.9 µM 0.330692586197214 0.367222463486588 no 1215 0.370438351445714 1797 3913820 SGTC_2003 4023581 200 µM 0.330327969926359 0.367368447115269 no 1216 0.370576080506512 1720 16641307 SGTC_852 0418-0143 439 µM 0.330232009935969 0.367406870386479 no 1217 0.370612330904796 1839 5369229 SGTC_181 1447-1644 8.07 µM 0.329567631472062 0.367672930087903 no 1218 0.370863341830635 1855 534600 SGTC_988 1497-1057 103 µM 0.329458874593024 0.367716489363145 no 1219 0.370904436848646 1892 3533044 SGTC_743 1275-0778 158 µM 0.328140631655514 0.368244606821271 no 1220 0.371402666831963 1843 2849257 YMR203W TOM40 SGTC_3294 9122953 26.2835 µM 0.323543339483726 0.37008832740781 no 1221 0.373141895380055 1690 16459826 SGTC_2989 9073649 71.4286 µM 0.32338048548318 0.370153694244661 no 1222 0.373203553304379 1885 21367202 SGTC_1991 st073000 8.92 µM 0.323158838225947 0.3702426657244 no 1223 0.373287476078026 1813 4301969 YIL048W NEO1 SGTC_2815 7968870 71.43 µM 0.323014604179092 0.370300566477805 no 1224 0.373342090951678 1695 2977326 YHR190W ERG9 SGTC_2998 9066762 71.4286 µM 0.322992452826602 0.370309459090746 no 1225 0.373350478886832 1847 4945196 SGTC_1139 k015-0024 46.9 µM 0.322798794267272 0.370387205855373 no 1226 0.373423813101699 1869 2766652 SGTC_2078 5212016 200 µM 0.322046786546445 0.370689159376452 no 1227 0.373708625242757 1865 1899708 SGTC_1105 epirubicin 18.1 µM 0.32188585330732 0.370753789225128 no 1228 0.373769585365533 1696 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_879 0831-1030 162 µM 0.32132774224422 0.370977951611474 no 1229 0.37398101747877 1713 1549252 SGTC_2204 7233102 200 µM 0.318336014427395 0.37218030820909 no 1230 0.375115034258879 1803 2172480 SGTC_2228 7354201 200 µM 0.317907010669018 0.372352824642813 no 1231 0.375277737265112 1836 753451 SGTC_2653 dihydrofissinolide 100 µM 0.31599308242185 0.373122789400137 no 1232 0.376003879380134 1790 6857746 SGTC_1042 0350-0096 82 µM 0.315606438993481 0.373278395974152 no 1233 0.376150624853352 1696 3122515 SGTC_29 0299-0004 12.984 µM 0.315208706317534 0.373438487038205 no 1234 0.376301597791555 1790 16871 A napthoquinone isolated from Swertia calycina. SGTC_1368 1852-0141 284 µM 0.314839045131967 0.373587298657633 no 1235 0.376441932214854 1756 2838987 SGTC_555 4296-0685 37 µM 0.313888034340604 0.373970226234601 no 1236 0.37680303932746 1785 2908540 YHR072W ERG7 SGTC_939 1165-0479 45.3 µM 0.313799097428164 0.374006043337656 no 1237 0.376836814967844 1880 1377347 SGTC_971 1315-0384 26.7 µM 0.313649833385337 0.374066158118859 no 1238 0.376893503207912 1701 6769120 SGTC_1555 citronellol 128 µM 0.309415449901258 0.375772789515376 no 1239 0.378502759657801 1900 8842 A terpine precursor. SGTC_1299 1079-1439 3.74 µM 0.309406067780433 0.375776573611144 no 1240 0.378506327638467 1723 323161 SGTC_3354 9151612 71.43 µM 0.308256281934946 0.376240407692733 no 1241 0.378943664632973 1879 27261949 SGTC_1140 3229-1848 2.98 µM 0.307647513560092 0.376486062839958 no 1242 0.379175280933546 1873 2849525 SGTC_1552 6-methylflavone 10.6 µM 0.306827129217394 0.37681719010613 no 1243 0.379487478744578 1881 689013 SGTC_3107 9121808 49.47 µM 0.306051850585876 0.377130194903602 no 1244 0.379782583782258 1887 662681 SGTC_111 0083-0039 52.457 µM 0.30436719101638 0.377810624023054 no 1245 0.380424080277224 1789 759313 SGTC_360 0957-0399 1.01 µM 0.304250757569981 0.377857665191966 no 1246 0.38046842879666 1865 6752301 YPR165W RHO1 SGTC_248 streptozotocin 5.23457 mM 0.302273097304398 0.378656951009467 no 1247 0.381221942467788 1878 5300 DNA alkylating agent. SGTC_2444 5485484 36.41 µM 0.302085289811429 0.378732881830566 no 1248 0.381293522975453 1848 6790631 SGTC_2979 9012552 45.46 µM 0.300055049580781 0.379554008928774 no 1249 0.382067582745068 1843 17100905 SGTC_2518 prenyletin 46.28 µM 0.299065239007932 0.379954533401188 no 1250 0.382445134203783 1881 3873459 A coumarin with calcium channel inhibitory activity. SGTC_848 0368-0089 85.6 µM 0.298994476280732 0.379983172306899 no 1251 0.382472130088833 1864 762535 SGTC_185 k048-0037 25.491 µM 0.298519771980256 0.380175310398438 no 1252 0.382653243901606 1912 6827589 SGTC_2953 9074162 66.49 µM 0.297523414661456 0.380578685353177 no 1253 0.383033467288834 1951 16451992 SGTC_2495 cafestol 54.53 µM 0.296886918279667 0.380836438728676 no 1254 0.383276421921572 1836 16667697 An anti-infammatory. SGTC_3285 9112818 20.8695 µM 0.29633544202453 0.381059805419738 no 1255 0.383486960970571 1790 17017947 YPR165W RHO1 SGTC_3098 9119039 49.47 µM 0.295318511365942 0.3814718009054 no 1256 0.383875288386327 1778 17161528 SGTC_1101 ebselen 5.29 µM 0.294976319344713 0.381610465533013 no 1257 0.384005984842888 1918 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_254 nsc-64875 3.808 µM 0.294635472405988 0.381748600205914 no 1258 0.384136180675377 1916 56993 SGTC_3233 9132340 49.47 µM 0.29369236838576 0.382130889391237 no 1259 0.384496493211685 1746 17682950 SGTC_2745 rifampicin 24.3 µM 0.292548692391081 0.382594635026491 no 1260 0.384933568080395 1929 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2964 9083345 53.42 µM 0.291965719653797 0.38283108767695 no 1261 0.385156417153267 1733 17741579 SGTC_2271 7849410 118.62 µM 0.291136436300932 0.383167518686392 no 1262 0.385473487074915 1952 972430 SGTC_1072 oxiconazole 14.9 nM 0.289827446008699 0.383698740726405 no 1263 0.385974124868174 1820 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_37 0566-0070 1.56 µM 0.289776284858613 0.383719507687772 no 1264 0.385993695877646 1885 1626686 SGTC_1913 st060213 96.1 µM 0.289457777985454 0.383848801187205 no 1265 0.386115542919769 1919 688959 SGTC_244 nsc-207895 1.295 µM 0.289323169841269 0.383903447406281 no 1266 0.386167041588881 1760 42640 SGTC_1816 st051957 91.6 µM 0.288305246241126 0.384316763605264 no 1267 0.386556545828163 1803 674121 SGTC_1641 st009299 47.1 µM 0.287057098074552 0.384823739379373 no 1268 0.387034300539196 1863 4046054 SGTC_1038 k292-0204 154 µM 0.282886901400267 0.386519023799186 no 1269 0.388631767906188 1755 4454212 SGTC_2886 9058944 51.95 µM 0.282523805221642 0.386666734129433 no 1270 0.388770947905908 1802 4949929 SGTC_300 r073-0011 5.04 µM 0.281108543304917 0.387242630161487 no 1271 0.389313574333782 1908 2735780 SGTC_441 propafenone 146 µM 0.279930234592653 0.387722295043334 no 1272 0.389765515154809 1808 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_913 3487-1245 167 µM 0.279345690284461 0.387960314481987 no 1273 0.389989772743791 1721 4016153 SGTC_2379 9035213 200 µM 0.279344908736387 0.3879606327472 no 1274 0.38999007260545 1961 646551 SGTC_2945 9067681 61.76 µM 0.278308676321977 0.388382677682325 no 1275 0.390387708190862 1857 16456930 SGTC_1315 1237-0019 3.69 µM 0.276393620866925 0.389163003210113 no 1276 0.391122877889727 1915 825140 SGTC_2066 5222451 176 µM 0.275240118901205 0.389633235413673 no 1277 0.391565883185567 1813 2281147 SGTC_1202 1988-0068 29.6 µM 0.274081040255739 0.390105903782245 no 1278 0.392011171912083 1741 2850480 SGTC_3216 9129716 49.47 µM 0.274079558798143 0.390106508019805 no 1279 0.392011741141306 1775 8056934 SGTC_996 3970-0799 1.8 µM 0.272904874269441 0.390585706448579 no 1280 0.392463169786833 1944 6615648 YGL040C HEM2 SGTC_3031 9088762 49.47 µM 0.272471202080979 0.390762659856522 no 1281 0.39262986565427 1819 205253 SGTC_717 1532-0246 73.2 µM 0.270878746230819 0.391412631292122 no 1282 0.393242146078197 1809 9561992 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.270694409551207 0.391487889154035 no 1283 0.393313038436487 1803 61125 An anti-inflammatory. SGTC_1914 st062367 72.6 µM 0.270693848646851 0.391488118156779 no 1284 0.393313254154964 1796 978205 SGTC_252 miconazole 1.30953 nM 0.268247364520535 0.392487311131288 no 1285 0.39425445942301 1885 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_384 k007-0144 5.16 µM 0.267761674116883 0.392685761364327 no 1286 0.394441386698085 1854 6824886 SGTC_2774 tamoxifen 10.92 µM 0.266750970150594 0.393098818431997 no 1287 0.394830453408033 1849 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2457 5731572 11.68 µM 0.266713276605364 0.393114225457309 no 1288 0.394844965428731 1949 2865357 SGTC_1116 jasmonic acid  1.58368 µM 0.266058157330484 0.393382028509943 no 1289 0.395097209736511 1895 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1745 st081495 74 µM 0.266011619889083 0.39340105424715 no 1290 0.395115129986644 1840 13842402 YBL026W LSM2 SGTC_2024 5144227 134 µM 0.265071452377505 0.393785474056263 no 1291 0.395477209320477 1907 3475211 SGTC_2674 ligustilide 100 µM 0.2644826479787 0.394026279725259 no 1292 0.395704016913084 1854 5319022 A signalling regulator. SGTC_327 1273-0057 3.96 µM 0.264387554435751 0.394065174311392 no 1293 0.395740650283127 1909 3108138 SGTC_536 3852-0578 10.6 µM 0.264323959958916 0.394091185929482 no 1294 0.395765149621397 1959 2869208 SGTC_2106 5357045 167.29 µM 0.264070513213674 0.394194856226956 no 1295 0.395862792340894 1901 668842 SGTC_1481 3346-2004 36 µM 0.263973847141245 0.394234398660593 no 1296 0.395900035567702 1877 2770522 SGTC_775 4577-0580 57.3 µM 0.26338545289096 0.394475111989494 no 1297 0.396126750900813 1895 2006902 SGTC_808 0711-0032 135 µM 0.262359695929924 0.394894847645794 no 1298 0.396522071290154 1970 4252555 SGTC_1984 st072354 53.1 µM 0.262180057858642 0.394968367396773 no 1299 0.396591313651462 1870 5762938 SGTC_26 0302-0163 425.158 µM 0.262099963904839 0.395001148332733 no 1300 0.396622187303707 1873 3100915 SGTC_2650 prasterone 100 µM 0.260137779629676 0.395804464735589 no 1301 0.397378748438414 1885 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_944 3370-0224 231 µM 0.25895780469955 0.396287758791349 no 1302 0.397833898584566 1786 4580514 SGTC_945 3381-0768 11.3 µM 0.258375128089854 0.396526470285754 no 1303 0.39805870499084 1961 1126236 YIL048W NEO1 SGTC_2918 7977171 22.06 µM 0.25824349443784 0.396580403457113 no 1304 0.398109496150478 1831 2236483 SGTC_271 rotenone 740 µM 0.256958636138459 0.397106941627955 no 1305 0.39860535235108 1925 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1360 1598-0022 39.8 µM 0.256952125891715 0.397109610021969 no 1306 0.398607865221744 1920 761525 SGTC_1783 st039459 87.517 µM 0.256514740432716 0.397288894858352 no 1307 0.398776699949646 1975 729761 SGTC_2922 7999257 32.47 µM 0.256181623070648 0.397425454635587 no 1308 0.398905298962267 1846 2988377 SGTC_1897 st060201 15 µM 0.256023671866754 0.397490210327863 no 1309 0.398966279412938 1799 611878 SGTC_120 rhodamine 6G 52.259 µM 0.255036303759226 0.397895068325542 no 1310 0.399347529885471 1909 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_600 1495-0418 41.6 µM 0.253522407341365 0.398516036150202 no 1311 0.399932274033398 1864 5377768 SGTC_174 3553-0389 74.3 µM 0.252553432082282 0.398913624021464 no 1312 0.400306659683038 1909 738071 SGTC_354 2783-3500 4.88 µM 0.250396183910624 0.39979915771955 no 1313 0.401140490220715 1779 6740761 SGTC_378 3970-0959 8.33 µM 0.25004133890145 0.39994486835434 no 1314 0.401277689964503 1896 6615653 SGTC_2940 9060638 45.86 µM 0.249842993956859 0.400026321161962 no 1315 0.401354384739335 1862 4027022 SGTC_2129 girgensonine 121.053 µM 0.249463326801602 0.400182248309559 no 1316 0.401501202643628 1904 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_605 1315-0399 119 µM 0.248773966869238 0.400465405186795 no 1317 0.401767814780388 1918 24020461 SGTC_1950 st077106 7.18 µM 0.248306038671596 0.400657638064575 no 1318 0.401948813553354 1832 13831864 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.24819323899941 0.400703981693279 no 1319 0.40199244861344 1895 368090 SGTC_2735 sertaconazole 140 nM 0.247542262181298 0.40097146213455 no 1320 0.40224429423105 1966 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2487 5918373 44.05 µM 0.246402057622663 0.401440073604417 no 1321 0.402685506791027 2014 2876279 SGTC_795 0685-0265 78 µM 0.245060912457326 0.401991450873532 no 1322 0.403204633785527 1852 302754 SGTC_2710 st078562 53.7235 µM 0.243622105343072 0.402583196263015 no 1323 0.403761753227854 1897 17250908 SGTC_1143 3454-2408 5.08 µM 0.243000695147366 0.402838835854825 no 1324 0.404002429470152 1897 X1143 SGTC_44 0929-0055 61.211 µM 0.242696314931488 0.40296406884609 no 1325 0.404120331190027 1839 1379590 SGTC_2206 7254556 146.969 µM 0.242593324829568 0.403006444940655 no 1326 0.404160226393295 1978 4398905 SGTC_2027 5150920 200 µM 0.242390628716321 0.403089849191715 no 1327 0.404238747554987 1960 786715 SGTC_427 1354-0053 47.3 µM 0.241131760503949 0.403607939754688 no 1328 0.4047264987937 1964 6813657 SGTC_1361 1608-0041 5.61 µM 0.240015526797107 0.404067470263527 no 1329 0.405159109868879 1862 X1361 SGTC_1718 roemerine 11.9335 µM 0.236279162413573 0.405606614802673 no 1330 0.406608027603614 1952 235224 An aporphine alkaloid with mutagenic activity. SGTC_1844 rapamycin 4 nM 0.23614092669943 0.40566358729086 no 1331 0.406661658438212 1894 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2080 5212524 12.4 µM 0.235997534599945 0.405722687044101 no 1332 0.406717291627764 2039 260183 SGTC_2238 6671620 73.2395 µM 0.234709006415331 0.40625385648619 no 1333 0.407217298440752 1844 729941 SGTC_2973 9094665 17.96 µM 0.234660520137973 0.406273847339588 no 1334 0.407236116251743 1991 25237061 YIL048W NEO1 SGTC_1235 benzylparaben 21.5 µM 0.23450885167781 0.40633638170175 no 1335 0.407294981060279 1910 7180 SGTC_1364 1653-0028 37.6 µM 0.233601790850051 0.406710421407006 no 1336 0.407647068657484 1897 5718652 SGTC_2716 st080858 38.6235 µM 0.233282075257957 0.406842281081627 no 1337 0.407771188270358 1982 5296050 SGTC_822 1487-0950 154 µM 0.23306430782004 0.406932100526615 no 1338 0.407855734991214 2011 1958375 SGTC_305 1682-2595 20.8 µM 0.232819454200297 0.407033097670931 no 1339 0.407950802862017 1925 226033 SGTC_807 1315-0151 48 µM 0.2312974430798 0.407661034742124 no 1340 0.408541866481372 2030 4011080 SGTC_805 3852-0218 479 µM 0.231136094621499 0.407727616315611 no 1341 0.408604537381815 1839 6615355 SGTC_1201 1889-3372 45.9 µM 0.230847871515517 0.407846560234406 no 1342 0.408716494695314 1885 5392199 SGTC_916 4466-0038 42 nM 0.229470831672329 0.408414954125759 no 1343 0.409251494382124 2054 5722064 YGL116W CDC20 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.229166949083946 0.40854041223136 no 1344 0.409369579923741 1983 23847180 SGTC_2409 alverine citrate 63.97 µM 0.228872282899887 0.408662074290783 no 1345 0.40948409192217 1969 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_212 3807-4682 38.772 µM 0.22882969476324 0.408679658850201 no 1346 0.409500642993144 1990 3125501 YBL034C STU1 SGTC_867 0518-0118 155 µM 0.228591899082326 0.408777847605941 no 1347 0.409593060735001 2057 6848158 SGTC_2275 7947463 200 µM 0.228313397148981 0.408892851752281 no 1348 0.40970130508363 2017 1225414 SGTC_1248 0469-0687 58.6 µM 0.228228961517426 0.408927720017989 no 1349 0.409734123738121 1940 4017482 SGTC_337 1315-0038 354 µM 0.227713911257487 0.40914042910733 no 1350 0.409934328460803 1902 1626437 SGTC_493 zm226600 134 µM 0.227428447844331 0.409258333330034 no 1351 0.410045300804404 1945 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1508 1080-0625 72.9 µM 0.225434640671662 0.410082058734017 no 1352 0.410820582878417 1982 767111 SGTC_376 3970-0862 59.1 µM 0.225089596122512 0.410224651506931 no 1353 0.410954787208212 2009 3135186 SGTC_549 1661-1316 519 µM 0.224165818024552 0.410606469523158 no 1354 0.411314139966163 2017 2857282 SGTC_389 tpck 16.7 µM 0.224045343796439 0.410656270452314 no 1355 0.411361010334284 1897 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2987 9018338 71.43 µM 0.223883688743934 0.410723096731879 no 1356 0.411423904045183 1923 5055682 SGTC_3257 9139206 32.98 µM 0.223663779506692 0.410814008760179 no 1357 0.4115094658541 1994 4910041 SGTC_161 4065-0411 162.148 µM 0.219389539881195 0.412581955339141 no 1358 0.413173308765354 1921 1906281 YLR208W SEC13 SGTC_3090 9117696 49.47 µM 0.219356222053725 0.412595743554668 no 1359 0.413186284640164 2013 7923821 SGTC_290 2043-6722 48.1 µM 0.218925884819556 0.412773843561303 no 1360 0.413353891182988 1968 773758 YLR208W SEC13 SGTC_1863 st057641 20.1 µM 0.218037752214949 0.413141464174351 no 1361 0.413699848478597 2080 3921635 SGTC_505 gw-5074 63.9 µM 0.21723874758755 0.413472257558268 no 1362 0.41401114471106 1995 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1122 capsaicin 818.572 nM 0.216748445506658 0.413675276401966 no 1363 0.414202195640645 1963 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.215693946973757 0.414111989573608 no 1364 0.414613159890923 2051 1273210 SGTC_2460 5552655 174.22 µM 0.215452690067865 0.41421191937981 no 1365 0.414707196851435 1881 5401989 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.2145147793033 0.414600459376266 no 1366 0.415072821493677 1885 6708784 An antioxidant flavonoid SGTC_1244 0416-0015 52.5 µM 0.214455433403254 0.414625046892531 no 1367 0.415095958713624 1915 96201 SGTC_3161 9100388 49.47 µM 0.214436265105953 0.414632988554263 no 1368 0.41510343193156 1965 25236368 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.213738725284939 0.414922011609802 no 1369 0.415375405346622 1902 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_80 0159-0065 512.242 µM 0.213725560047859 0.414927467020606 no 1370 0.415380538912669 2042 1548079 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.213723275953391 0.414928413505318 no 1371 0.415381429558929 2007 688801 SGTC_1752 st044819 83.042 µM 0.212787888603212 0.415316061436999 no 1372 0.415746205455156 1890 441209 YML126C ERG13 SGTC_1487 3970-0795 2.82 µM 0.212301545015848 0.415517646994978 no 1373 0.415935895078114 1977 3765103 SGTC_644 1498-1197 63.3 µM 0.211620293866806 0.415800057570223 no 1374 0.41620163783601 1985 6741615 SGTC_1663 st014140 55.4 µM 0.210748502414893 0.416161519463379 no 1375 0.416541762512579 2032 4207120 SGTC_977 1348-1378 135 µM 0.210469600928389 0.416277172497446 no 1376 0.416650587612093 1975 X977 SGTC_2074 5212007 75.395 µM 0.210204071088744 0.416387287401402 no 1377 0.416754201139678 2075 758611 SGTC_1112 tnp00069 1.16933 µM 0.209551036685383 0.416658127879066 no 1378 0.417009049058118 2012 145826 SGTC_668 1682-0499 62.6 µM 0.20909538584824 0.416847128641041 no 1379 0.41718688832785 1915 682214 SGTC_705 1124-0212 310 µM 0.208785947512211 0.416975492447773 no 1380 0.417307670923186 2047 9554485 SGTC_2068 5226020 147 µM 0.208532397694518 0.417080678708841 no 1381 0.417406644455329 1898 1810509 SGTC_1565 sinapyl alcohol 95.1 µM 0.20775462419803 0.417403378475457 no 1382 0.417710282068464 1880 5280507 A phenol propionate derived from cinnamic acid. SGTC_3246 9135460 32.98 µM 0.204974702528874 0.418557226853221 no 1383 0.418795944918459 2001 41446951 SGTC_2860 9025725 38.96 µM 0.204821393770958 0.418620880452251 no 1384 0.41885583577058 1840 40546248 SGTC_2265 7929201 200 µM 0.20414980641553 0.418899747749718 no 1385 0.419118216959507 1930 1265108 SGTC_744 1594-0068 283 µM 0.202722627509402 0.419492499076939 no 1386 0.419675918095362 1914 668392 SGTC_353 1988-1175 58.3 µM 0.201320604256975 0.420074980434228 no 1387 0.420223946256318 1879 2788357 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.200881789827182 0.420257325308758 no 1388 0.420395503539902 1968 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_908 3448-7491 47.7 µM 0.200094932061363 0.420584338891676 no 1389 0.420703168424342 1930 1203031 SGTC_2198 6589944 200 µM 0.199667777568826 0.42076188482341 no 1390 0.420870208029094 1997 5290268 SGTC_2531 methyl deoxycholate 70.07 µM 0.198681457636412 0.421171908302236 no 1391 0.421255964760303 1927 16667744 Haematoxylin. SGTC_2606 farnesol 9.78 µM 0.198410083167232 0.421284736516732 no 1392 0.421362114520021 2048 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_258 haloperidol 50.781 µM 0.197648579555174 0.421601378141119 no 1393 0.421660011747029 1889 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2644 guaiazulene 100 µM 0.197032001614088 0.421857795223086 no 1394 0.421901247478947 2055 3515 A coloring agent. SGTC_2307 7538926 6.34 µM 0.195273681344484 0.422589211804055 no 1395 0.422589349844743 1932 96582 SGTC_3230 9131665 49.47 µM 0.195234570209138 0.422605484087766 no 1396 0.422604658319762 1996 15943720 SGTC_3196 9111891 49.47 µM 0.194489892766122 0.422915334129278 no 1397 0.42289615451757 2053 18891510 SGTC_2319 6033012 152.6 µM 0.194354904958221 0.422971505811199 no 1398 0.422948998608302 1928 847246 SGTC_1456 k015-0012 13 µM 0.193522208830116 0.423318045333093 no 1399 0.423275007331893 2119 2989616 SGTC_228 caffeine 993.056 µM 0.193399406086652 0.423369156642514 no 1400 0.423323090264397 2069 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2301 7769476 200 µM 0.1911386473165 0.424310328835221 no 1401 0.424208484798857 1985 977820 SGTC_3283 9109332 35.8195 µM 0.190947410211263 0.424389962273291 no 1402 0.424283397750353 2019 17027281 SGTC_2949 9072542 2.23 µM 0.190264510120129 0.424674355280114 no 1403 0.424550931226094 1940 16457352 SGTC_679 0422-0091 41.4 µM 0.187015864804665 0.426027784650657 no 1404 0.425824097040563 1918 627384 YHR062C RPP1 SGTC_2355 9061122 103.12 µM 0.186635650621041 0.42618624429152 no 1405 0.425973156348137 2067 5302957 SGTC_1214 0358-0031 63.7 µM 0.185968258679569 0.426464418131587 no 1406 0.426234826495607 2088 4301366 SGTC_3137 9097352 49.47 µM 0.185848122122264 0.426514495816463 no 1407 0.426281932930419 2046 44120435 SGTC_2100 5377183 190 µM 0.184572308102438 0.427046378671465 no 1408 0.426782253829243 2027 2844202 SGTC_569 4130-2812 160 µM 0.184317999375373 0.42715241506819 no 1409 0.426881997185205 2109 743552 SGTC_1757 st041620 31.8375 µM 0.183294276357852 0.427579319098522 no 1410 0.427283562563305 1946 5289815 SGTC_1949 st076024 69.1 µM 0.182341764815248 0.427976603315005 no 1411 0.427657262228689 1942 2921930 SGTC_1773 st048542 73.5835 µM 0.180824334468887 0.428609660885659 no 1412 0.428252730909123 1914 3237138 SGTC_2678 equilin 100 µM 0.180785487639837 0.428625869833752 no 1413 0.428267977298486 2085 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_311 1315-0136 58 µM 0.180666706971341 0.4286754321467 no 1414 0.428314596344748 2070 6759207 SGTC_991 3996-0057 64.7 µM 0.179797941083527 0.429037966755972 no 1415 0.428655600027096 1999 715343 SGTC_1384 3089-0840 101 µM 0.178698986915825 0.4294966442972 no 1416 0.429087032352293 2088 1069836 SGTC_1849 st056239 19.2 µM 0.178656954449419 0.429514189551021 no 1417 0.42910353533092 1876 5393181 SGTC_2250 alverine citrate 130 µM 0.177805667549631 0.429869564896474 no 1418 0.429437798108124 1921 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_411 enrofloxacin 100 µM 0.176409462944779 0.430452542646739 no 1419 0.429986135447824 2126 71188 A bacterial gyrase inhibitor. SGTC_1965 Pectolinarigenin 58.4 µM 0.176136900002364 0.430566367570356 no 1420 0.430093196035622 1974 5320438 An anti-inflammatory. SGTC_667 1498-1044 59 µM 0.175321308875354 0.430907000743423 no 1421 0.430413584509508 1994 6739982 SGTC_3268 9137683 49.47 µM 0.174898910430839 0.431083436472692 no 1422 0.43057953321445 1965 1953228 SGTC_792 4534-1957 155 µM 0.174860228677712 0.431099594519696 no 1423 0.430594730822164 1993 1717904 SGTC_1142 3253-1408 9.78 µM 0.174164969749388 0.431390036011488 no 1424 0.430867907418355 2117 256655 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.172514713608192 0.4320795718309 no 1425 0.431516447493361 1961 279621 SGTC_654 1124-0271 80.9 µM 0.172265815279642 0.432183588433736 no 1426 0.431614279007604 1936 5403748 SGTC_3236 9132701 49.47 µM 0.172214791143091 0.432204912409478 no 1427 0.431634334978148 1979 24282524 SGTC_1841 st054148 70 µM 0.170245936233774 0.433027885297896 no 1428 0.432408363544017 1964 675442 SGTC_2720 fluspirilene 36.88 µM 0.16907294414753 0.433518329291149 no 1429 0.432869632988409 2074 3396 An atypical antipsychotic. SGTC_2588 indole-3-carbinol 100 µM 0.168230312716376 0.433870708226755 no 1430 0.433201047337876 2112 3712 Induces cell cycle arrest. SGTC_277 nystatin 15.5 µM 0.168092968790862 0.433928148892512 no 1431 0.43325507037033 2042 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.16706968879719 0.434356154029208 no 1432 0.433657607806084 2111 77254 SGTC_2419 paclitaxel 166.5 µM 0.165529688237403 0.435000431679248 no 1433 0.434263542149752 1970 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1579 chlormadinone acetate 49.4 µM 0.16512930931427 0.435167963331701 no 1434 0.434421102087853 2119 45114258 A steroidal progestin. SGTC_2930 9013230 14.89 µM 0.164869372021907 0.435276735839641 no 1435 0.434523400023316 2081 2995857 SGTC_692 k241-0027 77.8 µM 0.164530669238938 0.435418475644088 no 1436 0.434656702577765 2108 3600480 SGTC_145 3737-0113 38.366 µM 0.164201399631998 0.43555627582222 no 1437 0.43478629965804 2134 6849351 SGTC_1609 st001574 46.4 µM 0.161900049700721 0.436519614255585 no 1438 0.435692281839842 1991 3960012 SGTC_491 tetrandrine 80.3 µM 0.16188716321686 0.436525009566184 no 1439 0.435697355871479 2105 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2797 7859098 81.82 µM 0.161238493499509 0.436796609716385 no 1440 0.435952782155903 2011 972681 SGTC_2895 9054447 58.44 µM 0.160723870787856 0.437012105145331 no 1441 0.436155443842239 2005 2697450 SGTC_2928 9011484 9.79 µM 0.159271424594631 0.437620409608954 no 1442 0.436727516610942 1999 2994751 SGTC_2746 daunorubicin 9.88 µM 0.155116823883229 0.439361222955539 no 1443 0.43836460958861 2124 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2779 methotrexate 400 µM 0.155029975900254 0.439397625642499 no 1444 0.438398842820158 2135 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1269 0831-0796 3.05 µM 0.15474677266473 0.43951633499464 no 1445 0.438510477421071 2116 927758 SGTC_117 lucigenin 22.078 µM 0.154461076741478 0.439636094709246 no 1446 0.438623099560498 1903 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1966 st070145 16.1 µM 0.153534459878123 0.440024557430909 no 1447 0.43898840869813 2079 3748532 SGTC_3141 9094609 49.47 µM 0.153427355827112 0.440069462060892 no 1448 0.439030636721988 1911 25236309 YDL196W YDL196W SGTC_2020 4017018 200 µM 0.152566030962842 0.440430610595145 no 1449 0.439370257347119 2040 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3225 9130819 49.47 µM 0.150647235690431 0.441235328102331 no 1450 0.44012699893905 2115 4547121 SGTC_877 0771-0151 33.1 µM 0.148883797384379 0.441975105023691 no 1451 0.440822663262718 2055 6166523 SGTC_2822 7994718 71.43 µM 0.148832348303707 0.441996691389144 no 1452 0.440842962325112 2137 1018011 SGTC_404 fumagillin 50 µM 0.148216105570241 0.442255260221252 no 1453 0.441086110896666 2034 12015870 A methionine aminopeptidase binder. SGTC_1342 1486-1464 234 µM 0.147212280197038 0.442676507197895 no 1454 0.441482234003342 2046 3253938 SGTC_323 4013-0906 34.3 µM 0.145686256853914 0.443317014216786 no 1455 0.442084535524954 2163 2910086 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.145662382526333 0.443327036001201 no 1456 0.442093959478381 2040 4330530 SGTC_2060 5238662 140 µM 0.143602072003053 0.444192033425151 no 1457 0.442907352198036 2036 790130 SGTC_2975 9084847 53.72 µM 0.141604019304882 0.445031146646163 no 1458 0.443696395991116 1999 27211724 SGTC_2325 6158266 200 µM 0.141493508720467 0.445077564504484 no 1459 0.443740043872425 2049 3623240 SGTC_1600 coumarin 106 71.1 µM 0.141398779713075 0.445117354212525 no 1460 0.443777459116692 2103 100336 A hepatotoxic, DNA x-linker. SGTC_1970 st070122 35.8 µM 0.140227930357442 0.445609200039301 no 1461 0.444239952347029 2117 102928 SGTC_2202 7226349 200 µM 0.140018316437135 0.445697262694454 no 1462 0.444322759262995 2129 844334 SGTC_3026 9090633 49.47 µM 0.139894197223555 0.445749408717306 no 1463 0.444371793074598 2069 25236842 SGTC_2489 cantharidin 73.42 µM 0.139535760574508 0.445900003445247 no 1464 0.4445133997407 2157 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1488 4013-0813 75.9 µM 0.138999974591857 0.446125124839844 no 1465 0.444725084562923 2044 2910057 SGTC_172 1112-0046 2.638 µM 0.138399450791194 0.446377467786273 no 1466 0.444962365522484 2046 2802135 YIL048W NEO1 SGTC_895 0964-0006 13.7 µM 0.13795615405581 0.446563757113335 no 1467 0.445137535058746 2154 6738897 SGTC_3239 9133757 49.47 µM 0.13765075652924 0.446692103067104 no 1468 0.445258219698536 2107 17036923 SGTC_858 0438-0351 2.77 µM 0.137069910027891 0.446936224235692 no 1469 0.44548776813217 2045 2799119 SGTC_2992 9074591 71.4286 µM 0.137006852586145 0.446962727554723 no 1470 0.445512689305892 2190 17741321 SGTC_1409 3909-8004 61.9 µM 0.13686884998913 0.447020731477159 no 1471 0.445567230593322 2067 2119279 SGTC_2891 9063876 19.48 µM 0.136334606049314 0.447245290419236 no 1472 0.445778383804618 2215 6472478 SGTC_3167 9103034 49.47 µM 0.136243181664015 0.447283720559871 no 1473 0.445814519688161 2150 5127859 SGTC_556 4058-0063 51.5 µM 0.135650607704971 0.447532820361934 no 1474 0.446048748007649 2064 6615692 SGTC_288 1315-0019 35.1 µM 0.135335478666349 0.44766529931873 no 1475 0.446173317593433 2091 6811474 SGTC_1390 3413-2614 145 µM 0.134401301566914 0.448058057795001 no 1476 0.446542626235937 2040 3421432 SGTC_3075 9116269 49.47 µM 0.131922462924181 0.449100488125153 no 1477 0.447522810532914 2087 17015205 YNL244C SUI1 SGTC_1700 st030840 7.9285 µM 0.131218978178794 0.449396390123792 no 1478 0.447801041674201 2181 5499307 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.129880990366292 0.449959256359437 no 1479 0.448330292185545 2114 65057 A dermal irritant. YDR527W RBA50 SGTC_1674 st016616 23.6 µM 0.129439639880228 0.450144946323097 no 1480 0.448504891701821 2082 625830 SGTC_2323 6148992 148.28 µM 0.129281774902772 0.450211367712717 no 1481 0.448567345962775 2073 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2432 5630864 12.22 µM 0.128726286663846 0.450445099410369 no 1482 0.448787117353053 2081 5714970 SGTC_205 1486-1330 71.903 µM 0.1284471331754 0.45056256477077 no 1483 0.448897566583341 2098 4118834 SGTC_3011 9081274 71.4286 µM 0.128241259383974 0.450649197447019 no 1484 0.44897902467431 2072 6625322 SGTC_2084 5306078 60.6385 µM 0.127842252241428 0.450817108252181 no 1485 0.449136905966043 2111 679340 SGTC_2391 6285546 200 µM 0.125902079391124 0.451633699718052 no 1486 0.44990471832992 2040 846083 SGTC_27 0485-0001 32.618 µM 0.125900746959799 0.451634260590387 no 1487 0.449905245696815 2179 2054479 SGTC_2300 7976697 71.57 µM 0.124250653360151 0.452328923112207 no 1488 0.45055840867513 2061 2236109 SGTC_2600 tangeritin 87.95 µM 0.123807745786178 0.452515404918705 no 1489 0.450733749377028 2133 68077 A bioactive flavone. SGTC_930 2810-3379 265 µM 0.123621281439993 0.452593917003294 no 1490 0.45080757079253 2209 1015764 SGTC_1008 4106-0037 6 µM 0.121970933418316 0.453288887747844 no 1491 0.451461019067987 2149 2905394 SGTC_2366 9070441 60.58 µM 0.120657398385502 0.453842127035191 no 1492 0.451981201776639 2153 6837235 SGTC_616 4092-0450 108 µM 0.11911286172269 0.454492774915398 no 1493 0.452592970554001 2116 787165 SGTC_1254 0550-0035 264 µM 0.119004969059093 0.454538230108618 no 1494 0.45263570951035 2142 15121435 SGTC_1608 st001473 40.5 µM 0.118160785166705 0.454893905398769 no 1495 0.452970130564762 2015 7292267 SGTC_963 1269-2853 151 µM 0.116744816791202 0.455490568514806 no 1496 0.453531137206467 2086 3668223 SGTC_2038 4100038 30.985 µM 0.116685560757276 0.455515540119467 no 1497 0.453554616475482 2124 3596803 SGTC_2290 7904846 200 µM 0.115337464294697 0.456083700556538 no 1498 0.454088822140481 2081 2962154 SGTC_862 0452-0056 10.2 µM 0.115056471487269 0.456202137404983 no 1499 0.454200180711622 2187 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_334 1502-1024 68.5 µM 0.114509747633816 0.456432589500001 no 1500 0.454416859866409 2117 3296216 SGTC_1539 benzyladenosine 56 µM 0.114025377126697 0.456636770994173 no 1501 0.454608838300577 2163 92208 A nucleotide analog. SGTC_2476 5806916 10.51 µM 0.113949070940294 0.456668938141525 no 1502 0.454639082939344 2144 2870194 SGTC_2403 6032726 181.2 µM 0.113459981391525 0.456875122333722 no 1503 0.454832944189219 2124 2881040 SGTC_422 cantharidin 155 µM 0.112785796782082 0.457159355583854 no 1504 0.455100189506728 2159 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2181 6316240 54.2555 µM 0.111952783180996 0.457510580688358 no 1505 0.455430422346079 2094 12779990 SGTC_2160 5660466 132.927 µM 0.110926039847993 0.457943534059891 no 1506 0.45583749810652 2217 2859134 SGTC_1967 st070177 51.4 µM 0.108916893656462 0.458790887386869 no 1507 0.456634203580104 2174 5729214 SGTC_1900 st060200 72.8 µM 0.108893864318038 0.45880060105654 no 1508 0.456643336635222 2104 688945 SGTC_2991 9074669 71.4286 µM 0.108447806238559 0.458988751161163 no 1509 0.456820240411866 2185 17333109 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.108216872731314 0.459086163979694 no 1510 0.456911830525708 2137 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1992 st073643 23.3 µM 0.107385703650786 0.459436789619595 no 1511 0.4572414978771 2221 3161292 SGTC_970 1315-0089 19.5 µM 0.107380300416241 0.459439069057867 no 1512 0.457243641063463 2211 6811083 YLR033W RSC58 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.10528196398806 0.460324384892501 no 1513 0.458076037041957 2233 5024745 SGTC_2659 sanguinarine 24.21 µM 0.105010314403074 0.460439011913203 no 1514 0.458183812131741 2180 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_566 0958-0068 16.5 µM 0.104381724041923 0.460704268568623 no 1515 0.458433212775058 2195 6815365 SGTC_704 1310-0270 142 µM 0.104350241687395 0.460717554158479 no 1516 0.458445704201855 2125 5718033 SGTC_2140 5586273 200 µM 0.103472203573502 0.461088104865417 no 1517 0.45879410469712 2225 854421 SGTC_966 1300-0360 30.2 µM 0.103437179212126 0.461102886591661 no 1518 0.458808002821423 2136 70588 SGTC_3189 9110682 49.47 µM 0.102404152704048 0.461538890501012 no 1519 0.459217943810849 2122 17122418 SGTC_3191 9110352 49.47 µM 0.102218945355059 0.461617064867086 no 1520 0.459291445151164 2210 17122424 SGTC_65 0798-0905 34.986 µM 0.0999803373912294 0.462562077689292 no 1521 0.460179967853286 2223 3602145 SGTC_2768 sulfasalazine 50.2 µM 0.099808974048374 0.462634426311902 no 1522 0.460247991684905 2222 5384001 An antioxidant and salicylic acid derivative. SGTC_1058 3448-5425 97.3 µM 0.0994313953479058 0.46279384223741 no 1523 0.460397878193047 2218 7279705 SGTC_886 0866-0150 153 µM 0.0974080496402493 0.463648211757388 no 1524 0.461201176220929 2226 271463 SGTC_1006 4099-6547 255 µM 0.0962918866601627 0.464119590097902 no 1525 0.461644377326075 2180 3146833 SGTC_1695 st026914 34.495 µM 0.0949350943279382 0.464692658875957 no 1526 0.4621831905754 2158 3289191 SGTC_2883 9059145 45.46 µM 0.0930041781238591 0.465508346530998 no 1527 0.462950120974518 2202 16476510 SGTC_155 k072-0202 43.6 µM 0.0927797678007491 0.465603154896471 no 1528 0.463039262312843 2239 5857737 SGTC_2811 7967822 32.47 µM 0.0922734655391488 0.465817063493285 no 1529 0.463240384921356 2205 2232244 SGTC_2889 9059656 51.95 µM 0.0920925232200063 0.465893512553457 no 1530 0.463312264407632 2190 3949838 SGTC_1738 st035555 74 µM 0.0897366929544636 0.466888976796146 no 1531 0.464248228397305 2184 5331140 SGTC_1060 3448-7350 82 µM 0.0875285061880075 0.467822241971033 no 1532 0.46512571385822 2246 570178 SGTC_2011 4012611 177 µM 0.0869948742750233 0.468047802200103 no 1533 0.465337793198971 2191 2049887 SGTC_639 0833-0042 114 µM 0.0868170082444323 0.468122986460904 no 1534 0.465408484022782 2171 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1638 st008370 60.6 µM 0.0866716200099363 0.468184443149079 no 1535 0.46546626772813 2268 24207134 SGTC_2706 st078239 82.5 µM 0.0863013861944655 0.468340947157372 no 1536 0.46561341828268 2278 15434492 SGTC_1854 st056233 32.9 µM 0.08629806689951 0.468342350300873 no 1537 0.465614737567838 2256 5393174 SGTC_507 nimesulide 162 µM 0.0857040997709254 0.468593440393402 no 1538 0.465850821488487 2246 4495 A COX2 inhibitor. SGTC_1927 st060202 13.8 µM 0.0847794025401924 0.468984366168778 no 1539 0.466218384483572 2269 688887 SGTC_2844 9010103 25.97 µM 0.0840074388496749 0.469310745103989 no 1540 0.466525258665683 2148 2480525 SGTC_1155 4088-0394 48.2 µM 0.0832304567301057 0.469639266607647 no 1541 0.466834147890093 2180 2326248 SGTC_257 daunorubicin 18.5 µM 0.0831688935456053 0.469665297475477 no 1542 0.46685862318925 2246 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1111 tnp00062 510.699 nM 0.0820193910114621 0.470151367312378 no 1543 0.467315646804793 2241 676306 SGTC_1504 k297-0033 30 µM 0.0817468320476968 0.470266626058731 no 1544 0.467424018182758 2222 4388117 SGTC_2569 tetrandrine 100 µM 0.0816346749375031 0.470314055374828 no 1545 0.467468613347291 2109 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1804 st050076 49.1 µM 0.08154945217284 0.4703500949003 no 1546 0.467502499329445 2210 3895976 SGTC_283 0987-0079 11.7 µM 0.0813695612153332 0.470426169088875 no 1547 0.46757402772529 2236 411556 SGTC_1684 st024538 14.6195 µM 0.0810295817924429 0.470569946124261 no 1548 0.467709213490569 2190 6732859 SGTC_3210 9128157 49.47 µM 0.0806855282955583 0.470715449988096 no 1549 0.467846023018212 2015 17590849 SGTC_204 PMA1.184 62.41 µM 0.0806258395860227 0.470740693373369 no 1550 0.467869758040225 2265 2252213 YGL008C PMA1 SGTC_452 diindolylmethane 8 µM 0.0801817743896706 0.470928499892114 no 1551 0.468046342707535 2226 3071 Inhibits expression of several cancer promoting factors. SGTC_809 3998-0021 90 µM 0.079960753668262 0.471021977615509 no 1552 0.468134235009201 2268 715485 SGTC_1234 0326-0494 15.5 µM 0.0797695448472114 0.471102848087342 no 1553 0.468210273401838 2230 1547813 SGTC_2394 5221648 200 µM 0.0796991890113039 0.471132604910234 no 1554 0.468238252239242 2212 788586 SGTC_552 k242-0005 476 µM 0.0789759199343252 0.471438519052471 no 1555 0.46852588816726 2189 4088318 SGTC_1722 st034304 3.6505 µM 0.0779138856849678 0.471887747921351 no 1556 0.468948276905151 2213 4036148 YLR033W RSC58 SGTC_2090 5301565 104.445 µM 0.077711643706468 0.471973298137239 no 1557 0.469028715890074 2215 2056344 SGTC_132 0417-1715 25.805 µM 0.0771859066270654 0.4721956957944 no 1558 0.46923782654007 2282 6769098 SGTC_2618 avocadyne 43.43 µM 0.0763426207753467 0.472552441225194 no 1559 0.469573259142876 2200 3015189 SGTC_1223 0764-0573 147 µM 0.0753670299196444 0.472965184698223 no 1560 0.469961345445138 2262 1609797 SGTC_2515 chrysin 20.77 µM 0.0746957464957662 0.473249201633666 no 1561 0.470228396012567 2246 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2900 5328528 85.29 µM 0.0733395326304547 0.473823050838774 no 1562 0.470767966947583 2252 795359 SGTC_1123 mangostin 811.285 nM 0.0731688548642725 0.473895272894224 no 1563 0.470835875076586 2141 5281650 An antioxidant. SGTC_1471 k673-0312 37 µM 0.0727304178811885 0.474080800810916 no 1564 0.47101032133603 2280 24099884 SGTC_1545 lovastatin 49.4 µM 0.0724132005999806 0.474215037203695 no 1565 0.471136539907414 2219 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2605 digitonin 300 nM 0.0711597136710252 0.474745502006554 no 1566 0.471635321965926 2290 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2030 5175110 200 µM 0.0709393860619652 0.474838747394205 no 1567 0.47172299838805 2224 2831986 SGTC_2428 5615643 7.78 µM 0.0700444573470207 0.475217506484912 no 1568 0.47207913733142 2238 2253075 SGTC_1091 telmisartan 47.6 µM 0.0697654345164927 0.475335601418109 no 1569 0.472190179688202 2257 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3274 9138298 49.47 µM 0.0655829084951288 0.477106087272673 no 1570 0.473854948429778 2305 17015756 SGTC_982 1491-0518 27.5 µM 0.0652566895532822 0.477244196965768 no 1571 0.473984812766778 2218 3091256 SGTC_1015 4130-4525 82 µM 0.0650076619817277 0.477349628372314 no 1572 0.474083949890862 2157 1363237 SGTC_2116 5511452 16.8835 µM 0.0639458288104384 0.477799196957701 no 1573 0.474506680405565 2226 870744 SGTC_2568 diosmetin 100 µM 0.0636740257575707 0.477914279970682 no 1574 0.474614893604346 2301 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1827 berberine 7.24 µM 0.0633680137596144 0.478043849455887 no 1575 0.474736728682662 2254 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2566 crystal violet carbinol 226 nM 0.0626234419477982 0.47835912057213 no 1576 0.475033181038464 2093 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_614 0462-0418 107 µM 0.0624352979818457 0.478438787783364 no 1577 0.475108093027908 2264 5188303 SGTC_672 1441-0018 53.7 µM 0.0613135254217129 0.478913806127988 no 1578 0.475554759670044 2272 251141 SGTC_1495 4469-0029 237 µM 0.0612290279021995 0.478949588106873 no 1579 0.475588406086671 2278 793680 SGTC_481 bay k-8644 50 µM 0.0594972129991957 0.479682992918187 no 1580 0.476278042625582 2206 2303 A calcium channel antagonist. SGTC_557 1315-0110 16.2 µM 0.0588274806350455 0.479966635884874 no 1581 0.476544759988699 2306 6833801 SGTC_1282 0886-0010 32.4 µM 0.0575818498379454 0.480494208433779 no 1582 0.477040853706354 2297 2836211 YNL267W PIK1 SGTC_1720 st037298 9.481 µM 0.0563972909764785 0.48099594638004 no 1583 0.477512657505036 2252 597396 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0561638850295958 0.481094812599166 no 1584 0.477605625650364 2295 5106787 A p450 inhibitor. SGTC_3206 9114350 49.47 µM 0.0533234815144995 0.482298043646322 no 1585 0.478737085635553 2318 17087243 SGTC_843 0310-0051 143 µM 0.0527034152301811 0.482560733432638 no 1586 0.478984108924762 2218 2065037 SGTC_1696 st025591 34.7925 µM 0.0511922005506565 0.483200987858645 no 1587 0.479586183378209 2334 2787147 SGTC_1446 4239-0190 62 µM 0.0510577359536647 0.483257958428758 no 1588 0.479639756931087 2249 1340085 SGTC_2248 tofa 1.1 µM 0.0506694435601031 0.483422473825204 no 1589 0.47979446293326 2275 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1873 rapamycin 2 nM 0.0493577300237148 0.483978253739399 no 1590 0.480317106816393 2298 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1417 3966-0327 90.4 µM 0.0492088347781351 0.484041343424467 no 1591 0.480376435331591 2292 651118 SGTC_21 0849-0113 22.993 µM 0.0491315162095214 0.484074104897852 no 1592 0.480407243712338 2303 1560156 SGTC_517 1365-0151 113 µM 0.0490567433174478 0.484105787817811 no 1593 0.480437037853344 2215 768657 SGTC_683 panaxydol 45 µM 0.0483867714980056 0.484389674076576 no 1594 0.480704000885984 2296 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_453 enantio-paf c16 10 µM 0.0480059533461331 0.484551041176729 no 1595 0.480855748997568 2305 13871343 A lipid and platelet activating factor SGTC_2968 9090663 33.37 µM 0.0478983013295922 0.484596657880589 no 1596 0.480898646590651 2197 25236811 SGTC_1798 st045719 60.953 µM 0.0456575538719437 0.485546202044032 no 1597 0.481791597803423 2335 3980186 SGTC_2648 atorvastatin 78.68 µM 0.0453009812934283 0.485697311737001 no 1598 0.481933702642003 2322 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2657 nystatin 74.44 µM 0.0449584591610399 0.485842469012378 no 1599 0.482070210119295 2294 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_761 k216-0224 480 µM 0.0447781847126684 0.485918868181291 no 1600 0.482142056862597 2342 1340404 SGTC_815 1582-0027 36.9 µM 0.043473970524892 0.486471601111702 no 1601 0.482661856707653 2290 3128206 SGTC_1436 4092-1007 8.32 µM 0.0431163198396426 0.486623179965784 no 1602 0.482804405022986 2324 2881121 SGTC_398 bronopol 33.3 µM 0.0426685310945786 0.486812963688189 no 1603 0.482982882631058 2244 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_383 2324-0395 7.37 µM 0.0424021692869977 0.486925855696945 no 1604 0.483089049532666 2304 3146421 SGTC_636 0kpi-0074 126 µM 0.042161034784575 0.487028056531754 no 1605 0.483185162330253 2279 616434 SGTC_2504 purpurogallin 52.29 µM 0.042158157579894 0.4870292759921 no 1606 0.483186309149201 2216 5281571 An antioxidant. SGTC_2001 4023502 57.655 µM 0.0420683581670739 0.487067336196499 no 1607 0.483222102177699 2303 108941 YCR052W RSC6 SGTC_2149 5554786 194.827 µM 0.0418669812272038 0.487152687377117 no 1608 0.483302369235447 2296 745063 YPR165W RHO1 SGTC_1864 st057645 30.4 µM 0.041492077981487 0.487311587148483 no 1609 0.483451804136063 2338 688666 SGTC_1435 4092-0789 56.7 µM 0.0410917328445412 0.487481272487333 no 1610 0.483611382636491 2330 2248285 SGTC_3118 9124250 49.47 µM 0.0407864954242859 0.487610648169848 no 1611 0.483733052745561 2240 1504786 SGTC_3068 9116768 49.47 µM 0.0388740711651157 0.488421263348033 no 1612 0.484495394575472 2280 41904888 SGTC_1787 fluconazole 80 µM 0.0388654690144931 0.488424909633782 no 1613 0.484498823745583 2280 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_405 ebelactone b 50 µM 0.0383332168716977 0.4886505229221 no 1614 0.484711003503491 2256 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1814 st052110 31.539 µM 0.0382363362700012 0.488691589473912 no 1615 0.484749624957071 2316 674163 SGTC_3140 9094243 49.47 µM 0.0370139217720579 0.489209766810822 no 1616 0.485236952689214 2353 19291112 SGTC_831 k061-1017 217 µM 0.0364895398886753 0.489432056136264 no 1617 0.485446009558011 2324 1240153 SGTC_3114 9122766 49.47 µM 0.0352560762589387 0.489954943232666 no 1618 0.485937773802814 2236 17176985 SGTC_3138 9097216 49.47 µM 0.0346033059942894 0.490231671161422 no 1619 0.486198032638983 2366 25237486 SGTC_627 1391-0720 175 µM 0.0340268334019265 0.490476058245387 no 1620 0.486427876563175 2305 997839 SGTC_1660 st012960 28.1 µM 0.0340184689802887 0.490479604245558 no 1621 0.486431211553865 2297 24207266 SGTC_1637 st007924 17.4 µM 0.0328598070687356 0.490970812759001 no 1622 0.486893192393098 2351 683336 SGTC_518 1021-0119 62.6 µM 0.0319092950321106 0.491373787505412 no 1623 0.487272193025971 2215 1097762 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0312058302305858 0.491672030925373 no 1624 0.487552695164312 2315 676296 Flavone; oxidizing agent. SGTC_1847 st056231 15 µM 0.0311578042857409 0.491692392346109 no 1625 0.487571845432044 2335 5393180 SGTC_2033 5192550 145 µM 0.0307186946356626 0.491878561389751 no 1626 0.487746941017148 2336 182073 SGTC_610 4215-0184 155 µM 0.0305824570024292 0.491936322335366 no 1627 0.487801266444967 2311 5605015 SGTC_1073 triclabendazole 3.09 µM 0.0296585585754463 0.492328033824608 no 1628 0.48816968141796 2307 50248 An antihelmetic and likely tubulin inhibitor. SGTC_412 gemfibrozil 100 µM 0.0290493125166882 0.492586344084221 no 1629 0.488412630734592 2354 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_635 k038-0028 24.7 µM 0.0289505052647672 0.492628237021833 no 1630 0.488452032553133 2322 4035102 SGTC_1242 0402-0103 60.1 µM 0.0283311584953122 0.492890833503855 no 1631 0.488699014841529 2356 432868 SGTC_2408 sulbentine 18.36 µM 0.0280937007808883 0.492991513887422 no 1632 0.48879370907038 2242 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_408 cantharidin 100 µM 0.0278336574166937 0.493101770937946 no 1633 0.488897410809189 2282 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_891 0929-0073 133 µM 0.0277310815739111 0.493145262713743 no 1634 0.488938316859885 2334 5603632 SGTC_1756 st041558 35.5 µM 0.0276225476596836 0.49319128077838 no 1635 0.488981599046722 2367 3955792 SGTC_735 3076-0345 636 µM 0.0272519292611242 0.493348422583027 no 1636 0.489129398752524 2355 2888990 SGTC_994 3910-0338 138 µM 0.0270987245689095 0.49341338151162 no 1637 0.489190496017463 2344 3479481 SGTC_2339 9000433 200 µM 0.0270836791048615 0.493419760811483 no 1638 0.489196496086971 2338 2988954 SGTC_2430 5571206 200 µM 0.027045874499503 0.493435790029637 no 1639 0.489211572419707 2363 1731771 SGTC_2743 auranofin 4.32 µM 0.0267189299376406 0.493574415529616 no 1640 0.489341957307486 2338 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_487 nimodipine 119 µM 0.0260878013839903 0.493842018157962 no 1641 0.489593653419011 2365 4497 L-type voltage-gated calcium channels inhibitor SGTC_1928 4'-methoxychalcone 40.3 µM 0.025320392100066 0.494167408427684 no 1642 0.489899704300533 2369 641818 SGTC_560 2332-1943 155 µM 0.0248644847584763 0.494360720180335 no 1643 0.490081527763657 2365 21177716 SGTC_1293 1000-1278 195 µM 0.0244568099175883 0.494533581730812 no 1644 0.490244117046565 2329 678847 SGTC_250 brefeldin a 552.239 µM 0.023948930156326 0.494748933423007 no 1645 0.490446672419494 2351 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3244 9134489 49.47 µM 0.0236156300042317 0.494890260527588 no 1646 0.490579602343924 2320 16584271 SGTC_2516 gossypol 71.55 µM 0.0234012644740208 0.494981156894833 no 1647 0.490665098189443 2355 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_909 3448-9333 149 µM 0.0231493279152022 0.495087984654289 no 1648 0.490765579113544 2356 3344074 SGTC_1389 3405-0187 19 µM 0.023037664283538 0.495135333098428 no 1649 0.490810114580196 2352 799890 SGTC_3004 9076122 71.4286 µM 0.022809168911927 0.495232221619313 no 1650 0.490901247097168 2365 44782551 SGTC_2537 larixol 68.93 µM 0.0226375573516574 0.495304989975417 no 1651 0.490969692531058 2362 6708759 SGTC_2639 lactacystin 53 µM 0.0224362909356926 0.495390333062643 no 1652 0.491049965825364 2354 3870 A proteasome inhibitor. SGTC_1265 0819-1001 68.8 µM 0.022329738897681 0.495435514456025 no 1653 0.491092463291435 2366 3106768 SGTC_2260 7964312 200 µM 0.0213370981904266 0.495856427867669 no 1654 0.491488375246058 2369 231951 SGTC_2286 7945697 125 µM 0.0211917842232587 0.495918046328976 no 1655 0.491546334026164 2347 1245733 SGTC_993 3909-8757 62.7 µM 0.0211261826419456 0.495945863841826 no 1656 0.491572499412795 2349 4288324 YLR208W SEC13 SGTC_2210 7115885 190.385 µM 0.0204885870470244 0.496216229118393 no 1657 0.491826808191996 2366 2927039 SGTC_2313 7726885 200 µM 0.0199141372472319 0.496459819619008 no 1658 0.492055933744681 2358 726423 SGTC_87 0100-0052 35.5 µM 0.0190696131784875 0.496817935163077 no 1659 0.492392786095737 2365 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_869 0564-0080 44.1 µM 0.0190434214416439 0.496829041659999 no 1660 0.492403233189853 2312 6843321 SGTC_1170 0310-0127 64.8 µM 0.0179343804243636 0.49729932803084 no 1661 0.492845600903847 2363 774975 SGTC_372 0155-0182 15.9 µM 0.017716893970647 0.497391553137371 no 1662 0.492932351661712 2338 771486 SGTC_3319 9138450 16.7555 µM 0.016977075568036 0.497705274062897 no 1663 0.493227452091765 2353 2029690 SGTC_541 4513-1321 94 µM 0.0162420657171223 0.498016957321718 no 1664 0.493520638146651 2357 747515 SGTC_613 3914-0030 117 µM 0.0156562420788128 0.498265378569919 no 1665 0.493754318238353 2367 1145395 SGTC_1129 3453-1384 223 µM 0.0155354980785018 0.498316580713605 no 1666 0.493802482267301 2351 1084452 SGTC_3337 9144342 33.5465 µM 0.0143945976769969 0.498800386925661 no 1667 0.494257584686956 2387 17682949 SGTC_365 0121-0052 13.6 µM 0.0142374570495765 0.498867023581768 no 1668 0.494320268303348 2366 3101739 SGTC_876 0720-0963 56.8 µM 0.0135546930732413 0.499156555085719 no 1669 0.494592625418282 2378 765861 SGTC_3351 9150312 21.596 µM 0.0132862250204674 0.499270401232598 no 1670 0.494699719030468 2376 4904905 SGTC_3032 9089427 49.47 µM 0.0129999352051535 0.499391804913749 no 1671 0.494813922277663 2354 17173707 SGTC_1443 4112-3303 14 µM 0.0125177918120358 0.499596262126063 no 1672 0.495006254005188 2386 704433 SGTC_788 1182-0090 188 µM 0.012516544615561 0.499596791011028 no 1673 0.495006751525616 2373 5715185 SGTC_147 4466-0538 29.23 µM 0.0122342380871582 0.499716505668738 no 1674 0.495119366911585 2340 6742687 YHR072W ERG7 SGTC_2117 5521686 200 µM 0.0119992786679229 0.499816142372974 no 1675 0.495213095277224 2372 803312 SGTC_2702 st077768 96.8 µM 0.01170048298698 0.499942849447273 no 1676 0.495332289138235 2371 6484119 SGTC_1917 st066507 28.5 µM 0.0115657127887062 0.5 no 1677 0.49538605103053 2343 3156428 SGTC_2790 5423970 71.43 µM 0.0105411427114306 0.499565521639065 no 1678 0.495794770366641 2370 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_362 0310-0100 9.03 µM 0.0105401793709388 0.499565113125834 no 1679 0.495795154662544 2380 790235 SGTC_109 0132-0036 33.701 µM 0.0100434816607086 0.499354484049192 no 1680 0.495993297883578 2380 67274 A color developer. SGTC_1934 st074720 32.6 µM 0.00902149439147411 0.498921101899541 no 1681 0.496400993273846 2392 17250992 SGTC_3264 9137442 49.47 µM 0.0087058599195525 0.498787254726091 no 1682 0.496526908262987 2381 17015726 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.00756304066415618 0.498302634871408 no 1683 0.496982812074349 2386 688798 SGTC_651 3253-0966 34.4 µM 0.00750608691998015 0.498278483329521 no 1684 0.497005532685995 2388 781462 SGTC_3338 9144300 39.5675 µM 0.00608784267256971 0.497677071482015 no 1685 0.497571317163394 2389 4901274 SGTC_980 1473-0395 201 µM 0.00590257524556293 0.497598508488135 no 1686 0.49764522684484 2390 768876 SGTC_985 1493-0307 8.71 µM 0.00567312782742369 0.497501211017021 no 1687 0.497736761587679 2398 3278274 SGTC_1378 2093-0007 380 nM 0.00529447383512904 0.497340642635098 no 1688 0.497887820402603 2386 3618014 SGTC_312 4092-0653 6.84 µM 0.00464024820215119 0.497063219015121 no 1689 0.498148815443862 2384 1148278 SGTC_1846 st056244 14.8 µM 0.00414294690222714 0.49685233991926 no 1690 0.498347208043334 2369 5393182 SGTC_1381 2324-0066 62.1 µM 0.00375014155926655 0.496685772633292 no 1691 0.498503913481236 2395 10885928 SGTC_2348 9022543 33.42 µM 0.00325662599573537 0.496476500467328 no 1692 0.498700796495322 2393 3162678 YDL140C RPO21 SGTC_2786 7743617 45.45 µM 0.0015137537360283 0.495737454611629 no 1693 0.499396099863217 2402 583674 SGTC_695 3505-6186 243 µM 0.00108031662129799 0.495553662532428 no 1694 0.499569016107376 2404 1819379 SGTC_1 0258-0098 57.368 µM 0.00075589030754052 0.49541609535608 no 1695 0.499698443425693 2336 6790032 YDR047W HEM12 SGTC_2829 7992743 58.44 µM 0.000716274066331239 0.495399296834505 no 1696 0.49971424801502 2405 16462845 SGTC_1102 cgs 12066b 26.1 µM -0.000815263702125223 0.494749883605296 no 1697 0.499674756875575 2414 6438352 A 5-HT1B full agonist. SGTC_2411 st077133 39.94 µM -0.00183414156664466 0.494317859572149 no 1698 0.499268283791082 2412 1403142 YNL221C POP1 SGTC_758 0868-0029 16 µM -0.00223475569743143 0.49414799318547 no 1699 0.499108462208003 2410 762687 SGTC_1451 4152-0210 104 µM -0.00236259362606183 0.494093788212481 no 1700 0.499057462388007 2412 659563 SGTC_3045 9092950 49.47 µM -0.0024969474784761 0.494036820519153 no 1701 0.499003863114004 2407 44120432 SGTC_2111 5486399 200 µM -0.00463396814735487 0.493130714480313 no 1702 0.498151320796307 2416 689674 SGTC_2594 a-mangostin 100 µM -0.00694458713415425 0.49215104202121 no 1703 0.497229532840959 2437 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1924 st058459 75.1 µM -0.00753732055971966 0.491899738136247 no 1704 0.496993072619009 2427 688683 SGTC_41 0478-0632 82.643 µM -0.00925167295005335 0.491172914810999 no 1705 0.496309169147678 2423 3750424 SGTC_2035 5154463 94.595 µM -0.00963465113514221 0.491010549850292 no 1706 0.496156389770182 2427 2769623 SGTC_821 1114-0266 29.2 µM -0.0103759021902671 0.490696298090081 no 1707 0.495860688191726 2440 3123235 SGTC_1882 5615643 20 µM -0.0124305930779234 0.489825247182997 no 1708 0.495041038560573 2421 2253075 SGTC_3143 9086658 49.47 µM -0.0131212797955104 0.489532453104317 no 1709 0.494765516918758 2461 25236626 SGTC_2297 7971671 152.32 µM -0.0135417577147742 0.489354207973902 no 1710 0.494597785406096 2444 909016 SGTC_1478 0453-0656 35.7 µM -0.0136012040201356 0.489329008213863 no 1711 0.49457407194541 2432 5258496 SGTC_2220 6782180 200 µM -0.0143034070103844 0.489031342051227 no 1712 0.494293960754436 2430 833803 SGTC_1195 1502-0147 41.1 µM -0.0145667412784604 0.488919715353067 no 1713 0.494188916526 2421 817940 SGTC_1130 3454-2858 15.9 µM -0.0146999737621573 0.488863238786517 no 1714 0.494135770145729 2468 715628 YIL048W NEO1 SGTC_2070 5230947 200 µM -0.0168708814940679 0.487943034408469 no 1715 0.493269811331056 2428 2835538 SGTC_699 0375-0592 111 µM -0.0169617288530002 0.487904527394675 no 1716 0.493233573663809 2430 762578 SGTC_2800 7887935 81.82 µM -0.0185678621933338 0.487223762669854 no 1717 0.492592920334453 2457 2961002 SGTC_1416 3966-0321 25.3 µM -0.0186117200697249 0.487205173882575 no 1718 0.49257542659624 2452 582530 YLR208W SEC13 SGTC_1000 4048-0884 8.67 µM -0.0192660024617587 0.486927865187461 no 1719 0.492314452498742 2458 13040088 SGTC_2333 9017922 200 µM -0.0200356702994257 0.486601660041089 no 1720 0.492007458743374 2456 3163164 SGTC_18 0111-0177 500 nM -0.0204238371990706 0.48643714825132 no 1721 0.491852634239884 2441 721752 SGTC_2823 7987624 58.44 µM -0.020650127486685 0.486341243609371 no 1722 0.491762376512604 2457 2239440 SGTC_206 4546-0025 72.014 µM -0.0210273597431513 0.486181369640129 no 1723 0.491611915289544 2449 6620745 YIL048W NEO1 SGTC_3261 9137475 49.47 µM -0.0211022732012039 0.486149620996473 no 1724 0.491582035773665 2440 17027690 SGTC_2960 9079389 5.97 µM -0.0215632364395908 0.485954264745844 no 1725 0.491398179889708 2449 16457355 SGTC_1206 3978-0017 132 µM -0.0225131573432288 0.485551698887207 no 1726 0.491019308309199 2545 3873677 SGTC_719 2810-4230 27.3 µM -0.0227309490502021 0.485459403256859 no 1727 0.490932444218648 2435 721079 SGTC_1291 0993-0025 5.79 µM -0.0232817552498882 0.485225986445008 no 1728 0.490712762485675 2462 4353356 SGTC_455 paf C-16 10 µM -0.0248564351403681 0.48455870777301 no 1729 0.490084738104445 2450 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2064 5220758 200 µM -0.0250682063490614 0.484468971895746 no 1730 0.490000279933463 2484 788518 SGTC_801 0866-0028 10.1 µM -0.0251273442893373 0.484443912940514 no 1731 0.489976694738022 2450 6849771 SGTC_2803 7707263 71.43 µM -0.0265874087143127 0.483825248813488 no 1732 0.489394408050615 2473 2199229 SGTC_2853 9015042 58.44 µM -0.0270197290817704 0.483642071765384 no 1733 0.48922199912181 2462 6457456 SGTC_1691 st019933 84.6 µM -0.0273554963934981 0.483499807276538 no 1734 0.489088096842585 2451 6176082 SGTC_3353 9151644 39.2805 µM -0.0283976598333867 0.483058256462332 no 1735 0.488672495316225 2502 4909158 SGTC_1365 1672-3266 55.4 µM -0.0285831332064188 0.482979676018868 no 1736 0.488598532170074 2450 6415873 SGTC_2316 5844804 197.44 µM -0.0286409397858448 0.482955184947544 no 1737 0.488575480119155 2450 776813 SGTC_3323 9138564 53.9225 µM -0.0308930079171562 0.482001096064038 no 1738 0.487677433068577 2463 43912313 YNL103W MET4 SGTC_1114 scopoletin 1.73284 µM -0.0314406494001572 0.481769103068136 no 1739 0.487459061814768 2459 5280460 A coumarin with genotoxic properties. SGTC_1326 1431-2094 10.8 µM -0.0319065624059216 0.481571736912742 no 1740 0.487273282631281 2455 616278 SGTC_448 monastrol 171 µM -0.0324855426607619 0.48132648045794 no 1741 0.487042422615451 2443 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1898 st060199 18.6 µM -0.0324867172768106 0.481325982896885 no 1742 0.487041954258651 2448 688866 SGTC_1855 st056195 39.6 µM -0.0329176749725719 0.481143433498976 no 1743 0.48687011892189 2482 4028379 SGTC_730 1436-0052 41.2 µM -0.0329401532681231 0.481133912024492 no 1744 0.486861156239899 2462 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_865 0488-0499 301 µM -0.0339545923357527 0.480704221882438 no 1745 0.486456679934785 2459 9634651 SGTC_964 1287-0107 19.4 µM -0.0348913447123073 0.480307457710471 no 1746 0.486083191165756 2486 51516812 YPR165W RHO1 SGTC_1925 st057770 10.1 µM -0.0351063277876731 0.480216403746757 no 1747 0.485997477839587 2481 5989122 SGTC_1961 st076550 68.7 µM -0.0353480739646136 0.480114015768278 no 1748 0.485901094890755 2507 1579337 SGTC_1286 0929-0070 131 µM -0.0354023018198512 0.48009104855097 no 1749 0.485879474638596 2514 1420408 SGTC_1634 st006576 41 µM -0.0357988828547939 0.479923085913442 no 1750 0.485721361925139 2478 3915356 SGTC_421 streptovitacin 30 mM -0.0371046658802766 0.47937007735431 no 1751 0.48520077587875 2624 91467 include heat shock SGTC_164 4100-3994 89.624 µM -0.0376959235552239 0.47911968844795 no 1752 0.484965063110089 2455 4615967 SGTC_2174 5790901 200 µM -0.041181171530294 0.477643908037278 no 1753 0.483575731940208 2510 786020 SGTC_2687 chenodiol 100 µM -0.0413967644774046 0.477552628022543 no 1754 0.483489796080463 2501 5702181 A cholesterol synthesis inhibitor. SGTC_624 k048-0052 28 µM -0.0417987414715394 0.477382437913619 no 1755 0.483329569149 2517 6835531 SGTC_2733 amorolfine 100 µM -0.0418436728457014 0.477363415002417 no 1756 0.483311659792834 2500 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_470 aa-861 153 µM -0.0431779551756459 0.476798534225709 no 1757 0.482779838959157 2493 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3121 9125696 49.47 µM -0.0432089508013212 0.476785412490301 no 1758 0.482767485023156 2462 1235365 SGTC_3308 9128332 17.569 µM -0.0433967160444027 0.476705924204764 no 1759 0.482692647726944 2500 17332805 YDL196W YDL196W SGTC_19 0279-0214 38.434 µM -0.0447183756547977 0.476146441005294 no 1760 0.482165893347387 2495 3566274 YBR002C RER2 SGTC_764 1951-2361 146 µM -0.0454344688800791 0.475843324938209 no 1761 0.481880503575969 2489 5438930 SGTC_715 0868-0130 184 µM -0.0460497301892708 0.475582901307396 no 1762 0.481635306482131 2519 2876258 SGTC_1727 st034309 9.9045 µM -0.0468969524552532 0.475224311910416 no 1763 0.481297678505986 2549 870305 SGTC_367 0335-0881 7.1 µM -0.0469800993876701 0.475189120795434 no 1764 0.48126454420045 2507 23828853 SGTC_1164 k060-0068 93.7 µM -0.0489887443449887 0.474339041186877 no 1765 0.480464132941052 2484 5963676 SGTC_1401 3807-4679 7.6 µM -0.0490521375475086 0.474312214400139 no 1766 0.480438873080289 2491 3291456 SGTC_1658 st012944 20 µM -0.04943311387237 0.47415099498839 no 1767 0.480287069678196 2528 24207260 SGTC_475 α-linolenic acid 10 µM -0.0532030346390924 0.472555893593303 no 1768 0.478785068874752 2599 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3146 9095609 49.47 µM -0.0536257060258547 0.472377082918271 no 1769 0.47861668776417 2546 17173999 SGTC_1498 4478-3555 97.6 µM -0.0536644298603382 0.472360701119622 no 1770 0.478601261402254 2488 3437919 SGTC_902 1120-0002 2.07 µM -0.053769669660681 0.472316180526742 no 1771 0.4785593373264 2521 3280475 SGTC_3296 9122258 64.045 µM -0.0542278969400477 0.472122336324866 no 1772 0.478376797417511 2552 4730474 SGTC_3094 9117742 49.47 µM -0.0552424107129715 0.471693189422861 no 1773 0.477972670819313 2496 17149698 SGTC_2350 9023895 38.85 µM -0.055330935335435 0.47165574439822 no 1774 0.477937408537401 2561 2997209 SGTC_1779 st039427 55 µM -0.0555689982420684 0.471555047427702 no 1775 0.477842581073835 2495 1124498 SGTC_465 cgp-37157 41 µM -0.0568975349199768 0.470993130289494 no 1776 0.477313408991341 2496 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3231 9132313 49.47 µM -0.0575614791955535 0.470712330356676 no 1777 0.47704896696006 2544 4905967 SGTC_586 0957-0265 8.15 µM -0.0600686288059182 0.46965212166833 no 1778 0.476050487707599 2505 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_884 0851-0618 334 µM -0.0605215658220228 0.469460609049746 no 1779 0.475870120144249 2519 9642473 SGTC_1076 itraconazole 331 nM -0.0613803412870885 0.469097517647857 no 1780 0.475528154107783 2500 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2305 7443522 69.23 µM -0.0627948462331744 0.468499519253328 no 1781 0.474964934940807 2547 5415886 SGTC_2363 9053361 176 µM -0.0628230907643438 0.468487579268935 no 1782 0.474953689207047 2558 6469797 YMR079W SEC14 SGTC_3122 9126309 49.47 µM -0.0628853272503449 0.468461269756449 no 1783 0.474928909437895 2516 17591206 SGTC_2673 kobusone 100 µM -0.0629357765082169 0.468439943213538 no 1784 0.474908822883926 2528 6710676 An epoxy ketone and protein crosslinker. SGTC_662 k832-1615 104 µM -0.0632413901806917 0.46831075230789 no 1785 0.474787143063238 2570 5878478 SGTC_1009 4106-0057 9.87 µM -0.0647570963411484 0.467670073187927 no 1786 0.474183700935379 2505 2928005 SGTC_3262 9137218 49.47 µM -0.0659356969769753 0.467171944164471 no 1787 0.473714510165163 2492 17650664 SGTC_2421 5690543 90.72 µM -0.0659399000702176 0.467170167841948 no 1788 0.473712837014772 2571 3397993 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.06621516268543 0.467053837043451 no 1789 0.473603262595117 2563 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1768 st044301 37.178 µM -0.0667029662858597 0.466847689623566 no 1790 0.473409086409539 2551 3931349 SGTC_2914 7968218 45.32 µM -0.0671698558418705 0.466650388876493 no 1791 0.473223241231842 2584 2977111 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0679565786606071 0.466317949799609 no 1792 0.472910099773034 2546 2374 Ca(2+)-ATPase inhibitor. SGTC_2281 7943571 200 µM -0.0680357179757924 0.466284509838406 no 1793 0.472878600656114 2547 1244024 SGTC_2925 9010536 32.5 µM -0.0690842463467537 0.465841481455796 no 1794 0.472461280330346 2567 2994177 SGTC_1491 4138-0063 26.5 µM -0.0693940211353715 0.465710602253931 no 1795 0.472337993945742 2523 23883227 SGTC_3352 9151559 45.5865 µM -0.0702644952422428 0.465342848658175 no 1796 0.471991570663525 2574 17159339 SGTC_554 4483-2211 187 µM -0.0706277442038356 0.465189393767679 no 1797 0.47184701443202 2612 747107 SGTC_1907 st060210 83.7 µM -0.0708254756387996 0.465105864097803 no 1798 0.471768328053498 2531 688793 SGTC_2322 7413319 38.22 µM -0.0718871784727387 0.464657384722437 no 1799 0.471345846872992 2623 1840400 SGTC_207 4185-0010 4.486 µM -0.071908818557805 0.464648244087318 no 1800 0.47133723601305 2530 3761753 SGTC_1665 st014639 11.4 µM -0.073403881891603 0.464016784219235 no 1801 0.470742364314139 2556 981133 YIL048W NEO1 SGTC_1554 st069299 38.7 µM -0.073645861453793 0.463914589415139 no 1802 0.470646089015674 2593 24207999 SGTC_274 sirtinol 40.1 µM -0.0737570391309446 0.463867636739572 no 1803 0.470601855838115 2574 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1731 st035964 63 µM -0.0753705803908039 0.463186261248955 no 1804 0.469959933029363 2601 6739575 SGTC_403 arphamenine a 50 µM -0.0757833043369785 0.463011991069504 no 1805 0.469795749566116 2555 5487158 An arginine aminopeptidase inhibitor. SGTC_1843 st055809 45.5 µM -0.0759200635703033 0.462954246878017 no 1806 0.469741347252329 2653 16413835 SGTC_1724 st037281 8.293 µM -0.0759664665517731 0.462934654208958 no 1807 0.469722888447375 2538 574124 YDL195W SEC31 SGTC_1090 efavirenz 20.7 µM -0.0761226286486812 0.462868718755531 no 1808 0.469660768656631 2579 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1872 amphotericin b 148 nM -0.07657465081703 0.462677869706619 no 1809 0.469480962722675 2583 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_716 1683-5115 658 µM -0.076596412670063 0.462668681814026 no 1810 0.469472306422748 2523 723597 SGTC_2851 9015922 71.43 µM -0.0775284146795288 0.462275207683833 no 1811 0.469101593824806 2609 2996893 SGTC_2795 7780010 54.55 µM -0.0779407923854869 0.462101121147954 no 1812 0.468937575227947 2631 953673 SGTC_3071 9117417 49.47 µM -0.0789733095872113 0.461665272706738 no 1813 0.468526926302617 2606 45595590 YGL055W OLE1 SGTC_603 3794-0023 45.9 µM -0.0797605436651337 0.461332994620999 no 1814 0.468213852948445 2543 3802260 SGTC_1238 0333-0287 48.8 µM -0.0809162264762457 0.460845249566205 no 1815 0.467754287709343 2556 7226 SGTC_3202 9113761 49.47 µM -0.0815114005457518 0.460594084881559 no 1816 0.467517629362413 2705 4798415 SGTC_2150 5556613 200 µM -0.0817426542816451 0.460496499563399 no 1817 0.467425679310994 2584 743190 SGTC_750 4073-0104 132 µM -0.0818674929486382 0.4604438206633 no 1818 0.467376042254042 2566 22330957 SGTC_2876 9059903 25.97 µM -0.0822981111873017 0.46026211550806 no 1819 0.467204828190644 2550 6916095 SGTC_1449 4112-4002 201 µM -0.0824206371550964 0.460210415543475 no 1820 0.467156112901687 2584 2059539 SGTC_897 1000-0139 31.4 µM -0.0835708902875989 0.459725097908897 no 1821 0.466698806067132 2542 6151020 SGTC_1954 st077032 68.9 µM -0.0842353491035414 0.459444775104865 no 1822 0.466434656765309 2643 698907 SGTC_1831 st055328 12 µM -0.0846718865952286 0.459260619029409 no 1823 0.466261123464698 2567 1103068 SGTC_2827 7993847 71.43 µM -0.0857716451494323 0.458796717832439 no 1824 0.465823973641758 2618 2985692 SGTC_66 0109-0187 42.4 µM -0.0860003386946543 0.458700257130051 no 1825 0.465733073992768 2536 759417 SGTC_1088 bifonazole 369 nM -0.0868094599894545 0.458358997235702 no 1826 0.465411484014733 2533 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_847 0342-0274 5.54 µM -0.0870609000112515 0.458252954609076 no 1827 0.465311552301946 2638 18097 SGTC_3310 9130229 44.1445 µM -0.0876049553242188 0.458023514226528 no 1828 0.465095331772963 2694 7761258 SGTC_1017 4239-0030 168 µM -0.0881501976907113 0.45779358726935 no 1829 0.464878649819702 2594 1149593 SGTC_1678 st019265 80.2 µM -0.090406482543713 0.456842270188699 no 1830 0.463982102732858 2585 5367020 SGTC_160 3453-0671 289.699 µM -0.0906436573158757 0.456742284490079 no 1831 0.463887870586956 2582 5322268 SGTC_1596 piperlongumine 63 µM -0.0912892595811466 0.456470132025222 no 1832 0.463631375983041 2635 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1308 1187-1617 41.4 µM -0.0915672513503779 0.456352951380188 no 1833 0.463520935870418 2551 2882570 SGTC_431 k089-0097 107 µM -0.0919235866203073 0.456202752497282 no 1834 0.463379375693149 2550 5499420 SGTC_272 doxorubicin 8.13 µM -0.0920253825069616 0.456159845660488 no 1835 0.463338936416353 2547 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1184 1269-1718 139 µM -0.0922179933309203 0.456078661842268 no 1836 0.463262421174606 2660 5403821 SGTC_392 N-ethylmaleimide 8.33 µM -0.0923270409121843 0.456032700030273 no 1837 0.463219102290176 2601 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0925355859455706 0.455944803272003 no 1838 0.463136259501735 2613 551469 SGTC_24 0417-1663 219 µM -0.0932615293775896 0.455638852270204 no 1839 0.462847896973112 2627 4329390 SGTC_1862 st057513 3.81 µM -0.0943780071910567 0.455168360802677 no 1840 0.462404442767141 2587 5393163 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0976344647350725 0.453796428616797 no 1841 0.461111278167895 2570 688803 SGTC_2083 5306046 65.942 µM -0.0978478170526434 0.453706563222197 no 1842 0.46102656850559 2611 539837 SGTC_2798 7813637 45.45 µM -0.0980290251993167 0.453630239024355 no 1843 0.460954622792452 2673 956368 SGTC_1331 1472-0049 76.2 µM -0.0985462443020514 0.453412397690617 no 1844 0.460749276495514 2577 24051409 SGTC_1895 st058434 18.3 µM -0.0992134207291752 0.453131418335184 no 1845 0.460484409616306 2587 5393175 SGTC_1314 1222-0010 41.1 µM -0.099245800116542 0.453117782448971 no 1846 0.460471555549594 2631 3526027 SGTC_2448 5185112 27.17 µM -0.100145687296135 0.452738836391034 no 1847 0.460114332201099 2682 5718189 SGTC_2496 diffractaic acid 79.83 µM -0.101107454800857 0.452333879872676 no 1848 0.459732580149753 2628 94870 An apoptosis inducer which activates caspases. SGTC_2697 mebhydrolin 72.4 µM -0.102736253505805 0.451648180180842 no 1849 0.45908614986567 2651 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_318 1488-0629 67.2 µM -0.102830523570177 0.451608498301141 no 1850 0.459048739682591 2663 3662576 SGTC_2755 lomerizine 42.69 µM -0.103167916662326 0.451466480594594 no 1851 0.458914851400221 2630 3949 A calcium channel blocker. SGTC_3123 9126162 49.47 µM -0.103855373299181 0.451177131092902 no 1852 0.458642061235873 2602 25239884 SGTC_2299 7976368 114.88 µM -0.104709671832379 0.450817594243012 no 1853 0.458303093571448 2666 2979718 SGTC_3304 9125678 46.087 µM -0.105947122244937 0.450296877174158 no 1854 0.457812153144167 2629 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2959 9079155 11 µM -0.106316478154573 0.450141469361604 no 1855 0.457665629005255 2729 16189457 SGTC_1564 D-Arginine 115 µM -0.107249633695774 0.449748874959221 no 1856 0.457295470236557 2630 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_539 4859-0462 2.54 µM -0.108913898895456 0.449048812607377 no 1857 0.456635391251542 2745 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1632 st005650 90 µM -0.110036812183322 0.448576555887596 no 1858 0.456190090132565 2703 2759605 SGTC_3155 9099265 49.47 µM -0.110040108360051 0.448575169741787 no 1859 0.456188783085473 2692 25236499 SGTC_308 4092-1169 104 µM -0.110581039983948 0.448347699527066 no 1860 0.455974291582186 2619 2268590 YDL196W YDL196W SGTC_1439 4092-1168 46 µM -0.110979695567231 0.44818006947914 no 1861 0.4558162239237 2595 2886240 SGTC_968 1309-0633 340 µM -0.111260366043973 0.448062056348314 no 1862 0.455704941766417 2602 3761976 SGTC_2207 7258803 200 µM -0.111390282858672 0.44800743195889 no 1863 0.455653432631917 2616 3666799 SGTC_2308 7584454 197.62 µM -0.112217495291464 0.447659648152545 no 1864 0.455325478775299 2665 893577 SGTC_3054 9094397 49.47 µM -0.112977031544469 0.447340352776177 no 1865 0.455024382391689 2637 2598354 SGTC_933 2914-0560 114 µM -0.114417575981377 0.446734867715024 no 1866 0.454453390936268 2700 463887 SGTC_593 1203-0218 61.7 µM -0.11484868346205 0.446553690060697 no 1867 0.454282530251402 2702 3666956 SGTC_1035 k081-0041 55.2 µM -0.114904504361624 0.446530231529453 no 1868 0.454260407390709 2585 731709 SGTC_3051 9093778 49.47 µM -0.115823024602976 0.446144253650207 no 1869 0.453896401163632 2602 17217378 SGTC_2232 chlorophetanol 41.5365 µM -0.116029497305313 0.446057497308654 no 1870 0.453814582103318 2626 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_770 0389-1121 67.2 µM -0.11669153183011 0.445779339020516 no 1871 0.453552250524675 2811 6753108 SGTC_1311 1190-0148 100 µM -0.116891085632793 0.445695500367012 no 1872 0.453473181180022 2710 1961333 SGTC_1748 st037455 53.6035 µM -0.117079127752864 0.445616500345402 no 1873 0.453398674805303 2738 580690 SGTC_1732 st034308 51.822 µM -0.117310838928167 0.445519157104582 no 1874 0.453306868058035 2581 830119 SGTC_1749 st037932 54.2 µM -0.118140283058566 0.445170729661579 no 1875 0.452978252832631 2732 594497 SGTC_2234 tolnaftate 200 µM -0.118965075148117 0.444824298412459 no 1876 0.452651512615578 2618 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_118 0083-0097 135.343 µM -0.120248034410312 0.444285510482393 no 1877 0.452143333920677 2649 5207356 SGTC_2521 angolensin 13.4 µM -0.121361130049667 0.443818141360245 no 1878 0.451702501493591 2750 821428 A flavenoid. SGTC_2491 paeonol 100 µM -0.121595413749953 0.443719779719847 no 1879 0.451609722917258 2605 11092 Increases levels of cortical cytochrome oxidase. SGTC_3327 9140648 26.9345 µM -0.122817125323035 0.443206912797238 no 1880 0.45112595644126 2661 8029710 SGTC_1157 4092-0394 27.6 µM -0.123033433796293 0.443116117733257 no 1881 0.451040311371667 2796 3659885 SGTC_3259 9138485 49.47 µM -0.123608697592904 0.442874666412034 no 1882 0.450812552811121 2741 17646153 SGTC_618 k072-0232 33.2 µM -0.123913893744926 0.442746577240876 no 1883 0.450691726058256 2698 5872756 YGL099W LSG1 SGTC_702 1488-0190 94 µM -0.124254052103358 0.44260382167321 no 1884 0.45055706319912 2696 949357 SGTC_1341 1486-1360 280 µM -0.124287388510364 0.442589831655595 no 1885 0.450543866193405 2605 3976547 SGTC_2996 9066192 71.4286 µM -0.124427874498058 0.442530875835439 no 1886 0.450488252091093 2658 6472854 SGTC_2166 5933061 31.504 µM -0.125700662558499 0.44199680054755 no 1887 0.449984438691227 3108 2877375 SGTC_2253 7938677 135.83 µM -0.125792592657775 0.441958229779295 no 1888 0.449948052699531 2835 2301972 SGTC_1759 st043059 70 µM -0.125904017447009 0.441911480434572 no 1889 0.449903951261267 2652 669426 SGTC_1762 st045503 25.4615 µM -0.126765494926428 0.441550066609454 no 1890 0.449563003212658 2689 4645554 SGTC_656 4090-1979 187 µM -0.1286910067361 0.440742437081683 no 1891 0.448801075909589 2667 22330961 SGTC_3269 9137823 49.47 µM -0.12949344955512 0.440405935994472 no 1892 0.448483603905725 2628 17682936 SGTC_1037 k284-1091 78.7 µM -0.129986872775897 0.440199042352527 no 1893 0.448288406288341 2622 3334711 SGTC_2824 7998404 51.95 µM -0.13004595599359 0.440174269698873 no 1894 0.448265033878686 2631 837851 SGTC_1176 0848-0131 83.3 µM -0.130818413074973 0.439850412309363 no 1895 0.447959478322886 2729 6769040 SGTC_2256 7954252 200 µM -0.130853249935506 0.439835807687789 no 1896 0.447945698870896 2713 2972920 SGTC_2002 4023503 131 µM -0.131170402607514 0.439702851863902 no 1897 0.447820254464128 2646 4736863 YCR052W RSC6 SGTC_1763 st044482 94.5 µM -0.1312096063597 0.439686417452499 no 1898 0.44780474844128 2763 88505 SGTC_504 lovastatin 124 µM -0.131267085335437 0.43966232216277 no 1899 0.447782014274064 2646 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_395 anisomycin 6.25 µM -0.132070845327525 0.439325407987655 no 1900 0.447464127968417 2685 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2488 5268135 45.7 µM -0.132818060805792 0.439012235136006 no 1901 0.447168635225145 2756 1270356 YLR208W SEC13 SGTC_1955 wogonin 32.4 µM -0.133124630391775 0.438883756764715 no 1902 0.447047408138312 2901 5281703 A flavanone. SGTC_2841 9004761 38.96 µM -0.134743091471976 0.438205592858577 no 1903 0.446407500886823 2665 2991039 SGTC_2122 5258151 111.688 µM -0.137610978269376 0.437004344204066 no 1904 0.445273939338244 2684 2173356 SGTC_1525 8-methoxypsoralen 92.5 µM -0.137786752673857 0.436930737764487 no 1905 0.445204477163448 2778 4114 Related to psoralen; DNA damaging agent. SGTC_1240 0356-0016 42.1 µM -0.138066077383017 0.436813773592529 no 1906 0.44509409764969 2729 4305613 SGTC_1942 st076330 65.2 µM -0.138483768061383 0.436638880490127 no 1907 0.444929048610457 2803 24208414 SGTC_3144 9087057 49.47 µM -0.14049256435052 0.435797942153086 no 1908 0.444135413506973 2616 17249618 SGTC_1437 4092-1038 11.6 µM -0.141611109343841 0.435329813455779 no 1909 0.443693595692805 2676 3977136 SGTC_1087 pterostilbene 9.05 µM -0.1418024656279 0.435249736896221 no 1910 0.443618018231301 2772 5281727 Similar to reservatol, lowers cholesterol. SGTC_1019 4262-0212 3.4 µM -0.141815892334796 0.435244118343215 no 1911 0.443612715339363 2651 4677213 SGTC_866 0495-0101 262 µM -0.142722360675581 0.434864827000495 no 1912 0.443254728119883 2673 635694 SGTC_1726 st035556 14.5795 µM -0.142789990076383 0.434836531393077 no 1913 0.443228021416006 2891 5919439 SGTC_264 promethazine 12.5 mM -0.142929626518802 0.434778109663966 no 1914 0.443172880103488 2651 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1885 st057546 99.9 µM -0.142979520032822 0.434757235334163 no 1915 0.443153177821294 2814 702008 SGTC_2473 5854593 8.94 µM -0.143143727400998 0.434688535930293 no 1916 0.443088335517882 2627 2872951 SGTC_2153 5569715 200 µM -0.145807296748192 0.433574455808396 no 1917 0.442036757748638 2658 2054701 SGTC_2772 vinpocetine 57.06 µM -0.145812250556119 0.433572384288442 no 1918 0.442034802362317 2811 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3184 9108758 49.47 µM -0.14636716025841 0.433340350819558 no 1919 0.441815775199082 2636 902885 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.14657171367652 0.43325482334495 no 1920 0.441735040862285 2861 94937 An inhibitor of serotonin biosynthesis. SGTC_2837 9008476 45.46 µM -0.146891893728852 0.433120956565651 no 1921 0.441608675191542 2861 2992805 SGTC_1616 st002734 56.1 µM -0.147240686158437 0.432975135729547 no 1922 0.44147102381902 2693 4026101 SGTC_439 amiodarone 34.4 µM -0.147303410853329 0.432948913170809 no 1923 0.441446270188485 2733 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3064 1327-0027 10 µM -0.147367914522716 0.432921947205528 no 1924 0.441420814743211 2665 16000455 YPR107C YTH1 SGTC_2502 avocadyne acetate 18.59 µM -0.147952855759622 0.432677424925255 no 1925 0.44118998715727 2638 3952079 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.148060072439436 0.432632608058639 no 1926 0.441147679827933 2645 4620898 SGTC_82 0054-0107 293.755 µM -0.14809847554233 0.43261655566693 no 1927 0.441132526260295 2750 3104697 SGTC_486 niguldipine 82 µM -0.148259195765806 0.432549376261143 no 1928 0.441069108237449 2646 1236 A calcium channel blocker. SGTC_391 gliotoxin 8.33 µM -0.148419655333344 0.43248230775187 no 1929 0.441005794573354 2795 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_860 0443-0016 25.1 µM -0.148708907038625 0.432361411925814 no 1930 0.440891666296409 2692 5337942 SGTC_2474 5321570 43.32 µM -0.150422766942948 0.431645216246569 no 1931 0.440215540101782 2830 2841384 SGTC_3158 9100007 49.47 µM -0.151192231366052 0.431323741830723 no 1932 0.439912039161018 2703 19297233 SGTC_540 1187-0821 17.3 µM -0.151369925531202 0.431249509471837 no 1933 0.439841956011849 2684 847520 SGTC_2532 xanthone 78.9 µM -0.152022659880924 0.430976848277791 no 1934 0.439584531685612 2787 7020 An insecticide. SGTC_2864 9034755 47.6 µM -0.152228471144149 0.430890883296129 no 1935 0.439503369461217 2656 4930451 SGTC_694 1315-0438 43.2 µM -0.153097960242522 0.430527743950404 no 1936 0.439160512203181 2727 6793154 SGTC_1353 1498-1206 8.11 µM -0.153857047245643 0.430210761702632 no 1937 0.438861226043732 2671 6756808 SGTC_1513 0337-0559 19 µM -0.153862133401214 0.430208637959162 no 1938 0.438859220836657 2699 775073 SGTC_326 k292-0812 17.5 µM -0.154274890829129 0.43003629627169 no 1939 0.438696497248129 2656 3579357 SGTC_659 k018-0002 107 µM -0.154432684905495 0.429970414854059 no 1940 0.438634291974032 2752 6797879 YHR007C ERG11 SGTC_1628 st004252 77.7 µM -0.154670330378736 0.429871197948416 no 1941 0.438540610698493 2825 692968 SGTC_125 0133-0007 11.75 µM -0.155059682187077 0.429708653272953 no 1942 0.438387133317347 2785 26541 SGTC_1652 st011932 78 µM -0.155293362621554 0.429611103235534 no 1943 0.438295023999845 2734 1551076 SGTC_921 1561-0023 372 µM -0.15564774935828 0.42946317248255 no 1944 0.438155342516973 2662 24050882 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.156108179728287 0.42927099100211 no 1945 0.43797387546102 2679 1377 SGTC_1343 1487-0095 224 µM -0.156674324042954 0.429034707998993 no 1946 0.437750761793694 2684 4560101 YGL055W OLE1 SGTC_2401 5128683 200 µM -0.156968820173939 0.428911808696311 no 1947 0.437634710668788 2719 708373 SGTC_3169 9102970 49.47 µM -0.158291977516175 0.42835971308965 no 1948 0.43711336473086 2676 17027839 SGTC_745 0469-0705 296 µM -0.159742796777261 0.427754510915606 no 1949 0.436541843403871 2820 3486736 SGTC_718 1130-0073 349 µM -0.161564269409704 0.426994933257254 no 1950 0.435824498225644 2823 6740020 SGTC_1098 clofazimine 15.1 µM -0.162540373073671 0.426587996582072 no 1951 0.4354401689228 2776 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2723 salbutamol 83.58 µM -0.162728639060808 0.426509517648813 no 1952 0.435366048414279 2791 9884233 β2-adrenoceptor agonist SGTC_844 0330-0132 15.3 µM -0.163653230118381 0.426124142896762 no 1953 0.435002068992889 2805 2828079 SGTC_2123 5259487 200 µM -0.164665947653763 0.425702117486629 no 1954 0.434603460439724 2796 2173474 SGTC_1801 st050089 28.441 µM -0.165372052681565 0.42540791570536 no 1955 0.43432557476075 2690 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_722 3534-0461 190 µM -0.166208066825819 0.425059640419982 no 1956 0.433996605669618 2747 658262 SGTC_2810 7959871 45.46 µM -0.170208939986127 0.423393730155582 no 1957 0.432422910609219 2806 2974535 SGTC_564 3555-0129 330 µM -0.171310982522083 0.422935093465472 no 1958 0.431989622657142 2694 563260 SGTC_1603 st002045 67.8 µM -0.171857735979993 0.422707589971992 no 1959 0.431774686972418 2774 5887985 SGTC_2239 6685329 187.64 µM -0.172130186550366 0.422594233217153 no 1960 0.431667590749822 2849 805680 SGTC_488 nitrendipine 139 µM -0.172695223028278 0.422359162569497 no 1961 0.431445499423914 2692 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2961 9083290 32.55 µM -0.172972989375946 0.422243614295176 no 1962 0.431336329463922 2704 17741490 SGTC_2364 9055074 200 µM -0.174028542047872 0.421804575100979 no 1963 0.430921515586161 2806 6470630 SGTC_3016 9080866 49.47 µM -0.174277473911612 0.421701050263241 no 1964 0.430823700771119 2728 17066299 SGTC_883 0850-0245 24.6 µM -0.174813546306544 0.421478128895153 no 1965 0.430613071915877 2920 6823229 YPR165W RHO1 SGTC_3292 9120825 59.784 µM -0.174833840195006 0.42146969033974 no 1966 0.430605098606908 2761 24824900 SGTC_1366 1683-0113 21.9 µM -0.175371915605152 0.421245962296932 no 1967 0.430393703344195 2710 708623 SGTC_2443 5493264 126.67 µM -0.175793345189545 0.421070752535227 no 1968 0.430228148995221 2868 5340055 SGTC_3035 9091303 49.47 µM -0.175858087425278 0.421043837271646 no 1969 0.430202716748944 2719 25237002 SGTC_3 0833-0587 95.581 µM -0.176290976341884 0.42086388202512 no 1970 0.430032675424871 2743 5382644 SGTC_878 0828-0289 13.7 µM -0.177077147361893 0.420537107001488 no 1971 0.429723896006845 2736 745350 YLR208W SEC13 SGTC_298 1391-0729 10 µM -0.177386024336559 0.420408736062366 no 1972 0.429602592102515 2726 3237558 SGTC_773 4358-1457 44.6 µM -0.177461786823423 0.420377250055864 no 1973 0.429572839246755 2717 1186886 SGTC_96 0929-0093 37.281 µM -0.177481698342689 0.420368975145069 no 1974 0.42956501981584 2704 6991579 SGTC_1232 0279-0259 161 µM -0.177854999070533 0.420213843817364 no 1975 0.429418426414696 2733 1560000 SGTC_2096 5468907 200 µM -0.177970865517904 0.4201656961069 no 1976 0.42937292819614 2871 759785 SGTC_2055 5235184 200 µM -0.178849144567289 0.419800770633354 no 1977 0.429028077783046 2873 2836034 SGTC_321 4534-3890 65.3 µM -0.17905187682515 0.419716545041724 no 1978 0.42894848399866 2842 699746 SGTC_3183 9108214 49.47 µM -0.17992385860379 0.419354320140831 no 1979 0.428606172199066 2742 4974831 SGTC_1043 0916-0009 19.3 µM -0.180220461925027 0.419231125432386 no 1980 0.42848974757043 2780 3101130 SGTC_1383 3049-0032 20.7 µM -0.180320709216666 0.419189489334099 no 1981 0.428450399270342 2874 712864 SGTC_574 1315-0397 40 µM -0.180832375282541 0.418976991179387 no 1982 0.428249575108274 2710 6794277 SGTC_973 1325-0077 65.9 µM -0.181509203363849 0.418695936514338 no 1983 0.427983954947936 2796 2835149 SGTC_1430 4049-0248 69.1 µM -0.181742574541253 0.418599038124141 no 1984 0.427892376340152 2844 22774488 SGTC_637 1181-0519 7.26 µM -0.184529462194182 0.417442273665912 no 1985 0.426799058251857 2734 6252091 YGR060W ERG25 SGTC_598 3937-0236 20.2 µM -0.185169539300575 0.417176694816028 no 1986 0.426548030015267 2799 1379313 SGTC_3080 9117754 49.47 µM -0.185280276261781 0.417130752002861 no 1987 0.426504603725909 2939 9550191 SGTC_2834 9001755 58.44 µM -0.186255910934264 0.416726027344587 no 1988 0.426122040191859 2843 2989575 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.186726941349658 0.416530660332511 no 1989 0.42593736573174 2737 66535 A nucleotide analog. SGTC_110 0850-0284 111.64 µM -0.189391557760106 0.415425859807122 no 1990 0.424892970333232 2699 3906265 SGTC_961 1252-1571 372 µM -0.189821341049517 0.415247725860829 no 1991 0.424724566096526 2882 6813498 SGTC_1344 1488-0097 29.1 µM -0.18985672333117 0.415233061604962 no 1992 0.42471070268349 2835 747966 SGTC_1989 st071868 50.2 µM -0.191723720847003 0.414459448819133 no 1993 0.42397931206021 2890 16414057 SGTC_1255 0566-0045 221 µM -0.192601020382993 0.414096043616801 no 1994 0.423635722870491 2890 2788469 SGTC_1973 st070275 50.2 µM -0.192742032818197 0.414037638660405 no 1995 0.423580501590458 2702 17118334 SGTC_1997 st073024 93.8 µM -0.192979979334439 0.413939089564814 no 1996 0.423487323770746 2799 686268 SGTC_2744 captopril 92.04 µM -0.194182355222809 0.413441190677806 no 1997 0.423016549200517 2827 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2821 7996764 71.43 µM -0.195917869062631 0.412722767151721 no 1998 0.422337225406556 2956 2987135 SGTC_214 4373-3496 70 µM -0.196826681997711 0.412346676509166 no 1999 0.421981585158971 2784 3779166 SGTC_3003 9075612 71.4286 µM -0.197026073271779 0.412264173919922 no 2000 0.421903567081544 2821 6501993 SGTC_1643 st009866 20.2 µM -0.197101036620852 0.412233157163974 no 2001 0.421874236117266 2835 3156273 YOR207C RET1 SGTC_2258 7960471 200 µM -0.198301472044492 0.411736541078244 no 2002 0.421404600017446 2818 2974708 SGTC_2717 st081029 62.2815 µM -0.198376326422917 0.411705578748012 no 2003 0.421375319073938 2844 5292846 SGTC_1743 st037606 46.3785 µM -0.198387876878541 0.411700801133606 no 2004 0.421370800896812 2767 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_766 1391-0721 126 µM -0.198689251162424 0.411576148331855 no 2005 0.421252916360122 2939 1020919 YIL115C NUP159 SGTC_800 3448-7362 155 µM -0.198843974113336 0.411512156127633 no 2006 0.42119239820003 2832 15991913 SGTC_731 3966-0296 387 µM -0.199919002024918 0.411067598062105 no 2007 0.420771964483797 2768 660956 SGTC_1445 4239-0156 97.7 µM -0.202860434509731 0.409851807893604 no 2008 0.419622059962437 2944 4008346 SGTC_2311 7694451 200 µM -0.203154171802336 0.409730444050342 no 2009 0.419507265725 2843 2163142 SGTC_3222 9128301 49.47 µM -0.203168767076794 0.409724413926064 no 2010 0.419501561985659 2799 4911358 SGTC_2856 9022925 19.48 µM -0.203632270108323 0.40953292601138 no 2011 0.419320436786857 2913 4944862 SGTC_2386 9075165 157.42 µM -0.20376823759202 0.409476757590356 no 2012 0.419267307392771 2756 16452277 SGTC_814 3342-0569 96 µM -0.204496608210385 0.409175897994819 no 2013 0.41898272112532 2757 4346283 SGTC_183 3914-0051 30.55 µM -0.206030130266641 0.408542638918322 no 2014 0.418383687810501 2888 1596232 SGTC_1066 ketoconazole 628 nM -0.207261629013362 0.408034271368104 no 2015 0.417902769536864 2928 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2458 5808907 16.39 µM -0.207451632448929 0.407955850959556 no 2016 0.417828581327571 2831 2731747 SGTC_286 k060-0067 22.9 µM -0.208181201929313 0.407654768919087 no 2017 0.417543742865103 2794 5985051 SGTC_3242 9133940 49.47 µM -0.209902145476899 0.406944778478559 no 2018 0.416872023842683 2922 17248444 SGTC_582 0987-0078 156 µM -0.212585211112875 0.405838466714796 no 2019 0.415825253804245 2807 1625765 SGTC_3043 9092303 49.47 µM -0.213022964496749 0.405658038405699 no 2020 0.415654525339223 2790 25236084 SGTC_2561 acetosyringone 100 µM -0.21442873698568 0.4050787584791 no 2021 0.415106366957223 2766 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_8 0354-0001 70 µM -0.214827229528635 0.404914588500283 no 2022 0.414951011205389 2784 4993152 SGTC_2629 bisabolol 100 µM -0.215026784968247 0.404832382426875 no 2023 0.414873217793578 2945 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2128 5255449 168.493 µM -0.215629631570905 0.404584067677542 no 2024 0.414638228228838 2788 736008 SGTC_381 3461-2219 42.7 µM -0.215974718106148 0.40444194254188 no 2025 0.41450372726231 2908 2883159 SGTC_2372 9071633 200 µM -0.216703352331041 0.404141893344851 no 2026 0.414219767651212 2884 21321366 SGTC_2196 6573537 42.6665 µM -0.217692907849981 0.403734487924886 no 2027 0.413834194941908 2879 2903087 SGTC_50 0929-0078 56.389 µM -0.218633879620893 0.403347181546098 no 2028 0.413467629546151 2828 1377751 SGTC_2871 9038510 12.99 µM -0.21942733063371 0.403020668728377 no 2029 0.413158590991542 2884 4945164 SGTC_1788 fluconazole 20 µM -0.219583485320463 0.402956417509638 no 2030 0.413097777160249 2889 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_929 2805-0021 398 µM -0.22015687369181 0.402720514311535 no 2031 0.412874491200898 2888 3098024 SGTC_269 exalamide 29 µM -0.220945890527113 0.402395955251727 no 2032 0.412567282401671 2818 3316 A derivative of salicylamide. SGTC_440 fluspirilene 35.1 µM -0.222956348548762 0.401569265603296 no 2033 0.411784740082072 3032 3396 An atypical antipsychotic. SGTC_2601 securinine 100 µM -0.224126645617589 0.401088248186791 no 2034 0.411329379809874 2812 442872 A GABA receptor antagonist. SGTC_2611 pyromycin 23.93 µM -0.224826884306869 0.400800506563411 no 2035 0.411056975389951 2839 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_957 1187-1561 14.1 µM -0.225033032861631 0.400715806380576 no 2036 0.410976788360802 2777 1538454 SGTC_3313 9133968 57.047 µM -0.225182832643101 0.400654261126051 no 2037 0.410918522037154 2764 1494643 SGTC_1406 3909-7906 11.9 µM -0.22550957687179 0.400520026786582 no 2038 0.410791437984921 2833 X1406 SGTC_2486 5283202 22.39 µM -0.226327121147365 0.400184211561493 no 2039 0.410473502987523 2872 1377751 SGTC_1547 harmine 94.2 µM -0.226963545169817 0.39992284452026 no 2040 0.410226044599067 2826 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2357 9067248 200 µM -0.227213111499373 0.399820364683341 no 2041 0.410129016400834 2904 9150235 SGTC_1093 fluphenazine 7.97 µM -0.228685223192507 0.399216009622639 no 2042 0.409556790328504 2821 6602611 An atypical antipsychotic. SGTC_2398 5228213 48.84 µM -0.22889147607767 0.399131354611412 no 2043 0.409476632910649 2995 80771 YMR134W ERG29 SGTC_1833 st055984 71 µM -0.229411859573338 0.398917788044627 no 2044 0.409274409668948 2852 676288 SGTC_2655 perillic acid 100 µM -0.231386705852773 0.398107582467771 no 2045 0.408507196077325 2816 5702197 An apoptosis inducer. SGTC_2400 5203494 178.7 µM -0.231965569477848 0.397870179438699 no 2046 0.408282378017576 2766 6777674 SGTC_1034 k072-0165 12.7 µM -0.232204450601859 0.39777222074357 no 2047 0.408189610571864 2991 5835461 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.233226344651256 0.397353242431842 no 2048 0.407792824889099 2825 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1387 3342-1166 1.8 µM -0.234100697987536 0.396994850043157 no 2049 0.407453402035795 2893 3418228 SGTC_2593 nobiletin 86.24 µM -0.235965671284641 0.396230699203334 no 2050 0.406729654195374 2906 72344 An anti-infammatory. SGTC_3217 9129673 49.47 µM -0.236100983521795 0.396175272078891 no 2051 0.406677155381528 2999 17248312 SGTC_1306 1185-0270 9.02 µM -0.236395144691779 0.396054783879204 no 2052 0.406563031709372 2933 1548076 SGTC_2289 7946404 165.07 µM -0.237518502435723 0.395594748828981 no 2053 0.406127283483042 2825 1246120 YPR165W RHO1 SGTC_2176 5809774 33.9695 µM -0.237601737341156 0.395560668428362 no 2054 0.406095001448881 2958 2870539 SGTC_932 2857-0803 154 µM -0.237851646032672 0.395458348508623 no 2055 0.405998080073031 3059 674898 SGTC_1169 aniline yellow 25.8 µM -0.238037108680276 0.395382419339878 no 2056 0.405926156346538 2876 6051 A DNA damaging agent. SGTC_3085 9117376 49.47 µM -0.238573252501409 0.395162942204265 no 2057 0.405718253845658 2906 16480349 SGTC_677 0929-0063 136 µM -0.238675559870522 0.395121065187638 no 2058 0.405678584752784 2823 1539583 SGTC_2862 9027634 71.43 µM -0.238910973468663 0.395024708996517 no 2059 0.405587308166024 2790 5012562 SGTC_2094 5332512 191.667 µM -0.239120350004342 0.394939015324032 no 2060 0.405506131206359 2969 755774 SGTC_3341 9147222 25.867 µM -0.241044352274364 0.394151797685713 no 2061 0.404760370809446 2962 1939759 SGTC_3027 9089541 49.47 µM -0.242120738498587 0.393711575816838 no 2062 0.404343304602445 2932 9943819 SGTC_1590 st077108 57.8 µM -0.242347178869218 0.393618983204427 no 2063 0.404255579817908 2925 5489485 SGTC_2279 7948423 32.93 µM -0.242522941886073 0.393547116964322 no 2064 0.404187491157947 3043 1247112 SGTC_320 4092-0846 5.34 µM -0.243500824711659 0.39314734507661 no 2065 0.403808723152734 2927 1359356 SGTC_1171 0368-0077 21.4 µM -0.244851812807048 0.392595228047963 no 2066 0.403285586935279 2835 3239779 SGTC_3330 9141424 71.43 µM -0.245326449619862 0.392401306391019 no 2067 0.403101836772525 2977 27261020 SGTC_3166 9102297 49.47 µM -0.246739906466874 0.391823970839041 no 2068 0.402554760148151 2888 25237072 SGTC_2047 4141938 200 µM -0.247598308547536 0.391473467119814 no 2069 0.40222260978438 2863 3807862 SGTC_3018 9082602 49.47 µM -0.24898772363047 0.390906326370708 no 2070 0.401685138779404 2847 17332089 SGTC_270 tamoxifen 5.46 µM -0.249191491696564 0.390823170431844 no 2071 0.401606330263176 3042 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_68 0986-0284 82.829 µM -0.251150554567028 0.390023949507896 no 2072 0.400848855624101 3033 423278 YIL048W NEO1 SGTC_2017 5132927 60.65 µM -0.251310025798037 0.389958911898632 no 2073 0.400787212192993 2862 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1794 st048918 76.9 µM -0.251937085852723 0.389703206086452 no 2074 0.400544846779218 2866 672303 SGTC_1893 st059353 36.1 µM -0.252870008845872 0.38932286226252 no 2075 0.400184332949674 2911 3112488 SGTC_3023 9089636 49.47 µM -0.253095876416976 0.389230794129369 no 2076 0.40009706265488 2906 17249241 SGTC_794 k038-0031 316 µM -0.253196476817556 0.389189789398136 no 2077 0.400058194463546 2840 6624242 SGTC_3088 9117578 49.47 µM -0.253935787096317 0.388888484355103 no 2078 0.39977258331944 2912 678341 SGTC_1211 1056-0033 32.3 µM -0.255821268672303 0.388120361430571 no 2079 0.399044425112704 2963 6741922 SGTC_799 1310-0557 151 µM -0.255920998365557 0.388079744886859 no 2080 0.399005920043257 3015 5354492 SGTC_3284 9108171 64.8615 µM -0.256253405315808 0.387944375579016 no 2081 0.398877586702036 2976 8687505 SGTC_1215 3852-0577 11.2 µM -0.256479147491315 0.387852452164573 no 2082 0.398790439979624 3016 2884876 SGTC_2781 5567276 71.43 µM -0.25862308395946 0.386979743782748 no 2083 0.397963035317457 3026 2853274 SGTC_71 0417-1750 47.813 µM -0.258771753211867 0.38691924776599 no 2084 0.397905676685561 3080 6811472 SGTC_1334 1486-0610 236 µM -0.259781581553014 0.386508404419783 no 2085 0.397516129552097 2953 3742339 SGTC_2127 5253358 187.912 µM -0.259947335170276 0.386440980572183 no 2086 0.397452198886261 2806 20612 SGTC_854 0422-0053 192 µM -0.260754666572384 0.386112630217535 no 2087 0.397140853032895 2879 3596728 SGTC_3168 9103419 49.47 µM -0.260760902714952 0.386110094228483 no 2088 0.39713844833094 2907 16649256 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.260810581931916 0.386089891857371 no 2089 0.397119291803024 3080 165506 SGTC_2612 dictamnine 15.46 µM -0.260868777079491 0.386066226821476 no 2090 0.397096851809911 2958 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1466 k213-0079 57.5 µM -0.261492687844603 0.385812540384637 no 2091 0.396856293835655 2862 3657981 SGTC_483 fpl-64176 144 µM -0.26388068927132 0.384842014455297 no 2092 0.395935928063576 2870 3423 SGTC_2879 9041815 71.43 µM -0.264199278340448 0.38471258862308 no 2093 0.39581318355928 2987 4942971 SGTC_423 5-fluorouracil 457 µM -0.264652457664276 0.384528508050374 no 2094 0.395638602554537 2810 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2010 4012422 159 µM -0.265268090382684 0.384278480932382 no 2095 0.395401472195495 2958 952393 SGTC_1044 1222-0021 1.78 µM -0.266716916799686 0.383690258720839 no 2096 0.394843563946994 2995 4306703 SGTC_2626 ethyl orsellinate 100 µM -0.26718144061822 0.383501719128291 no 2097 0.394664732565121 2857 75653 A natural product. SGTC_218 alverine citrate 93.75 µM -0.26720364706943 0.383492706728143 no 2098 0.394656184128792 3007 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_356 1634-0012 32.5 µM -0.267246236230588 0.383475422262389 no 2099 0.394639789452431 2986 735457 SGTC_941 3237-0776 460 µM -0.267385198394495 0.383419027207746 no 2100 0.394586297334553 3066 760008 SGTC_1515 3460-0031 42.1 µM -0.268143225649912 0.383111440304489 no 2101 0.39429453721684 2901 2876596 SGTC_1484 3473-2379 286 µM -0.269733360865576 0.382466446161354 no 2102 0.393682696611887 2882 671917 SGTC_178 4092-0806 87.505 µM -0.26997586207695 0.382368110885081 no 2103 0.393589411789935 2962 2169044 SGTC_2776 terbinafine 19.92 µM -0.270892675337593 0.381996407794322 no 2104 0.393236789354188 2907 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2785 7756463 72.73 µM -0.270931597918268 0.381980629838095 no 2105 0.393221820983768 2880 2201551 SGTC_1200 1643-0193 18.4 µM -0.270993917951587 0.381955367718966 no 2106 0.393197855035642 2926 5403974 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.271797669957486 0.381629602976404 no 2107 0.392888798453273 2874 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1309 pyrazolanthrone 13.4 µM -0.274087715725778 0.380701896235127 no 2108 0.392008606959574 2982 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2437 5741531 144.16 µM -0.274277184762495 0.380625172199876 no 2109 0.39193580818852 3070 2262990 SGTC_135 0933-0004 26.348 µM -0.274980346234741 0.38034047341242 no 2110 0.391665668950075 3013 21230617 YGL099W LSG1 SGTC_956 1185-0240 191 µM -0.276166512290115 0.379860360770462 no 2111 0.391210088355347 2899 1416193 SGTC_1228 0124-0032 52.5 µM -0.276785840303202 0.379609755040567 no 2112 0.390972277185586 2971 X1228 SGTC_2463 5473429 200 µM -0.277138477140663 0.379467086175252 no 2113 0.390836888989086 2955 5399405 SGTC_2168 5727979 200 µM -0.279320114424184 0.378584810727185 no 2114 0.38999958563529 2845 695210 SGTC_1136 pergolide 1.05886 µM -0.279471085023894 0.378523780086467 no 2115 0.389941662572329 2897 47811 A dopamine receptor agonist. SGTC_1512 0259-0544 12.2 µM -0.280360438926038 0.378164315743367 no 2116 0.389600492784132 2921 18476 SGTC_173 1273-0061 2.693 µM -0.281948287958729 0.37752279183679 no 2117 0.388991581214249 3012 2847414 YPL266W DIM1 SGTC_1289 0976-0073 69.1 µM -0.282106773596446 0.377458778865411 no 2118 0.388930819756023 3010 3391136 SGTC_2614 arthonioic acid 13.39 µM -0.283293254862237 0.376979661467369 no 2119 0.388476023718129 2866 6710684 SGTC_1440 4100-1550 40 µM -0.283366866895372 0.376949942150591 no 2120 0.388447812152828 2925 742806 SGTC_2182 6325192 200 µM -0.284907528820107 0.37632809971306 no 2121 0.387857493886098 2911 736248 SGTC_281 1672-3440 14.9 µM -0.285051566926981 0.376269979385299 no 2122 0.387802317631507 3001 6833000 SGTC_88 0180-0332 8.668 µM -0.285291135023508 0.376173318289918 no 2123 0.38771055200219 2869 3101745 SGTC_1736 st036774 51 µM -0.286210046083047 0.375802627522762 no 2124 0.387358624894915 3151 1272247 SGTC_2869 9037858 32.47 µM -0.286288295313189 0.375771066898936 no 2125 0.387328661059641 2876 27187042 SGTC_2778 tioconazole 65.09 nM -0.286728693196412 0.375593454691748 no 2126 0.387160032824613 2857 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_989 1501-0895 10.3 µM -0.287156728654109 0.37542085350472 no 2127 0.386996158562825 2994 2830112 SGTC_75 0159-0059 199.013 µM -0.287438081198643 0.375307414372737 no 2128 0.386888453127066 3217 5377270 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.288254341909367 0.374978365526847 no 2129 0.38657602716399 2903 229346 A bile salt which induces apoptosis. SGTC_1571 st070080 73.4 µM -0.288681582854643 0.374806173550217 no 2130 0.386412528845487 3061 4315245 SGTC_1325 1431-0015 227 µM -0.289520202351728 0.374468255253837 no 2131 0.386091661154381 2910 1103340 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.291197432157401 0.373792711775864 no 2132 0.385450163181351 3050 521171 SGTC_2180 6301957 200 µM -0.291353372334067 0.373729922886035 no 2133 0.385390535898417 3039 845462 SGTC_163 TUB2.036 7.546 µM -0.291988732255138 0.373474131592905 no 2134 0.385147619561098 3035 15992207 YJR013W GPI14 SGTC_2051 5263410 176 µM -0.292002421498282 0.373468621015948 no 2135 0.385142386266036 2974 227584 SGTC_53 0973-0023 39.979 µM -0.293482748078592 0.372872871467443 no 2136 0.384576592139712 2913 674768 SGTC_995 3931-2021 34.6 µM -0.296029881028635 0.371848503413696 no 2137 0.383603630895883 3023 730143 SGTC_2482 5981709 142.65 µM -0.296131576343429 0.371807623876652 no 2138 0.383564800210263 2964 877755 SGTC_3077 9117319 49.47 µM -0.297866895966939 0.371110282267141 no 2139 0.382902377441435 2908 17154678 SGTC_3095 9117207 49.47 µM -0.298036687905714 0.371042073724336 no 2140 0.382837581198099 3038 17015229 SGTC_3162 9099653 49.47 µM -0.298106998072484 0.371013830023963 no 2141 0.38281075029127 3051 25237511 SGTC_938 3126-1755 342 µM -0.298305519550391 0.370934087396902 no 2142 0.382734995986288 3106 1777771 SGTC_3010 9080089 71.4286 µM -0.298442304235651 0.370879146591186 no 2143 0.382682802587886 3043 17027233 SGTC_3153 9100258 49.47 µM -0.298707121227864 0.370772787933645 no 2144 0.382581761522055 2949 25236848 SGTC_2023 5144124 124 µM -0.300860867411695 0.369908144512655 no 2145 0.381760295902954 2932 2830192 SGTC_1135 dihydrocapsaicin 536.708 nM -0.301989081246461 0.369455473553516 no 2146 0.381330193255624 2883 107982 A Capsaicinoid. SGTC_1568 digitonin 820 nM -0.303078258353464 0.369018636833026 no 2147 0.38091511135419 3108 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1649 st011737 51.3 µM -0.304712802675177 0.368363386952324 no 2148 0.380292448964562 2997 1761035 SGTC_1335 1486-0900 202 µM -0.305833738356616 0.367914251608189 no 2149 0.379865619488559 2908 X1335 SGTC_2388 9080168 200 µM -0.306486077769209 0.367652955987635 no 2150 0.379617289240922 2928 15943073 SGTC_739 1486-1183 203 µM -0.306763082281305 0.367542019895574 no 2151 0.379511855158911 3078 4346692 SGTC_1429 4049-0205 9.46 µM -0.306869781776418 0.367499291319413 no 2152 0.379471245346138 2959 22774478 SGTC_2705 st078069 42.8 µM -0.307006005920282 0.367444741770444 no 2153 0.379419400388729 3015 1530061 SGTC_1268 0828-0275 2.46 µM -0.30802579846717 0.367036461425464 no 2154 0.379031350887219 3043 745337 SGTC_1187 1391-0724 117 µM -0.308389319852546 0.366890959678426 no 2155 0.378893053874402 2991 6997986 SGTC_233 rapamycin 362 pM -0.310255757020764 0.366144207845938 no 2156 0.378183236474273 2973 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2118 5526350 200 µM -0.310807446823318 0.365923576508117 no 2157 0.377973504069773 3056 743594 SGTC_2361 9034121 116 µM -0.311287907490999 0.365731467181033 no 2158 0.377790879685711 2973 6496917 SGTC_1275 0867-0008 21.1 µM -0.311730055654294 0.3655547066261 no 2159 0.377622842117682 2920 3422836 SGTC_2004 4023728 41.89 µM -0.311944342128529 0.365469050144156 no 2160 0.377541411281006 3115 360084 YDR527W RBA50 SGTC_1011 4112-3381 17.4 µM -0.312136232837537 0.365392351589044 no 2161 0.377468495661096 3117 2877139 SGTC_2192 5915882 198.485 µM -0.312181481748658 0.365374266421489 no 2162 0.377451302383038 2939 2876149 SGTC_1810 st050138 53 µM -0.312544343013332 0.365229248195933 no 2163 0.37731343437864 3071 3444541 SGTC_3084 9116877 49.47 µM -0.312917339336376 0.365080199558191 no 2164 0.377171731886517 3035 27241325 SGTC_2641 levomentholum 100 µM -0.312954137357602 0.36506549624147 no 2165 0.37715775309693 3019 16666 SGTC_3332 9141069 11.198 µM -0.314331931996844 0.364515116353603 no 2166 0.376634474071503 2929 17332883 SGTC_2189 6047310 154.431 µM -0.315192326962248 0.364171560736822 no 2167 0.376307815537805 2924 711535 SGTC_471 1-acyl-paf 4 µM -0.315724529732067 0.363959106833554 no 2168 0.37610580315245 2946 16759367 SGTC_2759 disulfiram 3.38 µM -0.316107817724251 0.363806125200092 no 2169 0.375960336540185 2953 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2762 leflunomide 42.06 µM -0.316107850563583 0.363806112093868 no 2170 0.375960324077658 2959 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1333 1482-0047 286 µM -0.317077101120143 0.363419352287817 no 2171 0.375592549869724 3101 3811116 SGTC_1501 4491-0275 38.4 µM -0.318020459894795 0.363043057716356 no 2172 0.375234708605999 3077 5104718 SGTC_2916 7875993 68.79 µM -0.318156673066747 0.362988734817618 no 2173 0.375183048161216 3029 1299250 SGTC_136 0097-0015 404.482 µM -0.318421764457597 0.362883022161462 no 2174 0.375082515557654 3017 4861337 SGTC_2935 9038016 29.96 µM -0.319278381049272 0.362541493642941 no 2175 0.374757712445792 3133 6463195 SGTC_2390 9097792 176.6 µM -0.319368935553886 0.3625053964256 no 2176 0.374723382102835 2962 4497149 SGTC_342 k048-0088 23.3 µM -0.321581812520596 0.361623670685999 no 2177 0.373884762010492 2932 6820570 SGTC_1085 doxorubicin 7.67 µM -0.323710296140361 0.360776264289016 no 2178 0.37307868752737 3078 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3119 9125183 49.47 µM -0.324580744763581 0.360429911910398 no 2179 0.37274920114763 3002 22695334 SGTC_2855 9016525 58.44 µM -0.324690212620685 0.360386362639335 no 2180 0.372707771434449 2944 43811474 SGTC_1817 st052116 64.4 µM -0.325612076103842 0.360019692339467 no 2181 0.372358937160948 3108 4361398 SGTC_168 3970-0862 530.542 µM -0.32576129531408 0.359960352643473 no 2182 0.372302482266455 3053 3135186 SGTC_906 1165-0455 526 µM -0.326481641745078 0.359673941453837 no 2183 0.37202998840371 2974 3252859 SGTC_1681 tripelennamine 100 µM -0.326849276070344 0.359527799664906 no 2184 0.371890943759415 3021 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1793 st048256 72.231 µM -0.326981132197131 0.359475389296036 no 2185 0.371841077925838 2963 672022 SGTC_1667 st014849 34.6 µM -0.326992163431805 0.359471004704326 no 2186 0.371836906190499 2957 5348460 SGTC_903 1134-0042 114 µM -0.327943190767385 0.359093068889521 no 2187 0.37147730820535 3002 701009 SGTC_2621 lithochol-11-enic acid 100 µM -0.328196997551847 0.358992230016909 no 2188 0.371381358921609 3081 6708711 SGTC_2046 4110841 106 µM -0.328496721122661 0.358873160797155 no 2189 0.371268061517887 3146 44119630 YMR134W ERG29 SGTC_291 SEC14.278 35.5 µM -0.329759209563051 0.358371770923311 no 2190 0.370790955462852 3116 1068044 SGTC_1838 st055369 84.5 µM -0.330688474179103 0.358002874826656 no 2191 0.3704399046146 2969 676036 SGTC_2013 4024628 200 µM -0.332325887681143 0.357353183075278 no 2192 0.369821597053843 3137 5230760 SGTC_851 0394-0702 453 µM -0.332896491619933 0.357126876257543 no 2193 0.369606208915613 3135 762646 SGTC_2555 cholic acid 100 µM -0.334084245730981 0.35665596321051 no 2194 0.369157993926903 3149 6708657 Influences liver metabolism. SGTC_284 0988-0104 32.6 µM -0.334807322441832 0.356369389348865 no 2195 0.368885218246615 3072 4666532 SGTC_3033 9090887 49.47 µM -0.334885984272451 0.356338218533837 no 2196 0.368855547595917 2993 19325384 SGTC_1784 st039334 36.3 µM -0.334930848784827 0.356320440793398 no 2197 0.368838625389392 3223 3496984 SGTC_2237 6667747 47.222 µM -0.335235903328242 0.35619957000581 no 2198 0.368723570234587 2961 729940 YDL015C TSC13 SGTC_2312 7706453 155.7 µM -0.335827866479476 0.355965059565595 no 2199 0.368500337468912 3025 976098 SGTC_935 2996-0153 430 µM -0.335854149477474 0.355954648630403 no 2200 0.368490427025 3138 23738523 SGTC_1165 k072-0275 30.3 µM -0.336446666036113 0.355719975936508 no 2201 0.368267031975812 3126 6153523 YGL055W OLE1 SGTC_2142 5622915 118.518 µM -0.337507153725356 0.355300094673048 no 2202 0.367867310149144 3031 5322196 SGTC_2919 7978188 46.38 µM -0.340252986361218 0.354213748029603 no 2203 0.366833009295293 3185 2980291 SGTC_2214 7179297 48.276 µM -0.341293546833457 0.353802375430317 no 2204 0.366441302738486 3019 769744 SGTC_2295 7971645 200 µM -0.342542406781597 0.353308879549859 no 2205 0.365971368000074 3041 2978226 YKL099C UTP11 SGTC_3000 9075062 71.4286 µM -0.344117292383704 0.352686903867695 no 2206 0.36537903937081 3027 17057871 SGTC_201 4262-0159 12.803 µM -0.344510697976535 0.352531596042358 no 2207 0.365231126036985 3067 1341029 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.345725800298897 0.352052055830797 no 2208 0.36477439636987 3000 6708630 An antioxidant. SGTC_2787 5284540 71.43 µM -0.346304986437522 0.351823562705077 no 2209 0.364556760784544 3061 736958 SGTC_2942 9052777 62.25 µM -0.346333690348641 0.35181224019523 no 2210 0.364545976107719 3039 6469503 SGTC_1247 0448-0043 5.84 µM -0.34681949764277 0.351620629183739 no 2211 0.364363464126475 3129 3089013 YGL099W LSG1 SGTC_2058 5236698 133 µM -0.348253790922313 0.351055138547897 no 2212 0.363824796867158 3039 766665 SGTC_2984 9022109 38.96 µM -0.348425477778209 0.350987470619305 no 2213 0.36376033567134 3137 6459207 SGTC_2456 5770359 74.46 µM -0.349043432063342 0.350743951866449 no 2214 0.363528351747554 3176 3118787 SGTC_708 3448-5400 146 µM -0.349985830146655 0.350372696821649 no 2215 0.363174665938251 3126 3462195 SGTC_2226 7298446 200 µM -0.350397469905067 0.350210577331842 no 2216 0.363020212456995 3118 3283010 SGTC_380 3970-0968 6 µM -0.350489554797857 0.350174314511492 no 2217 0.36298566385666 3012 2891601 SGTC_756 0508-1999 28.3 µM -0.350699928115298 0.35009147510536 no 2218 0.362906739744645 3021 6753853 SGTC_1486 3970-0793 4.53 µM -0.351512210207848 0.349771687036806 no 2219 0.362602056897173 3104 2844330 SGTC_1273 0849-0096 14.1 µM -0.352357385359613 0.349439062376255 no 2220 0.36228512837199 3075 5286025 SGTC_621 3584-0052 32.1 µM -0.35352862055562 0.34897830558611 no 2221 0.361846088062913 3146 2273927 SGTC_213 1246-0773 967 nM -0.353873375542119 0.348842723444985 no 2222 0.361716890433224 3070 6251622 SGTC_2268 7933382 153.85 µM -0.354024980258424 0.348783107813697 no 2223 0.36166008124719 2990 935025 YOR257W CDC31 SGTC_1150 3909-7983 10.9 µM -0.356434858303264 0.34783597194191 no 2224 0.360757464060091 3056 23965914 SGTC_802 4112-3352 742 µM -0.356593038518437 0.347773836703463 no 2225 0.360698244887336 3174 704594 SGTC_1372 2752-0194 270 µM -0.357056078719625 0.347591972017526 no 2226 0.360524912085925 3017 823334 SGTC_3220 9131269 49.47 µM -0.357833005621521 0.347286903309236 no 2227 0.360234144459636 3080 17722206 SGTC_631 k072-0230 41.5 µM -0.358952338877445 0.346847559008226 no 2228 0.359815372196532 3139 5773147 SGTC_1524 corynanthine 62.1 µM -0.361201236942765 0.345965477197332 no 2229 0.358974508761064 3202 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.362390279644852 0.345499438043934 no 2230 0.358530201149861 3159 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2188 6126565 140.678 µM -0.36289060862087 0.34530340661791 no 2231 0.35834330123742 3151 874518 SGTC_3091 9116372 49.47 µM -0.365275670390002 0.344369498483802 no 2232 0.357452818874292 3205 17169793 SGTC_958 1222-0007 33 µM -0.367827628398565 0.343371289399079 no 2233 0.356500883292737 3209 7312461 SGTC_817 1391-0715 46 µM -0.367913928058137 0.343337551968302 no 2234 0.356468707233786 3090 1353946 SGTC_955 1216-0110 33 µM -0.368479707795678 0.343116400627372 no 2235 0.356257786614015 3016 3619719 SGTC_2102 5377816 72.7585 µM -0.369966885121303 0.342535350812277 no 2236 0.355703582167434 3234 1379702 SGTC_1233 0325-0408 14.2 µM -0.37060077703358 0.342287798257371 no 2237 0.355467451612934 3168 12874 SGTC_226 1,3-diallylurea 8.28947 mM -0.371751899740575 0.34183842587379 no 2238 0.355038789713853 3140 74537 YKL182W FAS1 SGTC_3266 9136860 49.47 µM -0.372027138753753 0.341731011919978 no 2239 0.354936321728084 3151 4871271 YPR165W RHO1 SGTC_1464 k208-0027 110 µM -0.373168903179846 0.341285567255673 no 2240 0.354511369454801 3253 X1464 SGTC_2107 5363541 170.161 µM -0.374126974120998 0.340911958764556 no 2241 0.354154925552956 3166 244052 SGTC_630 4356-0227 183 µM -0.376570509948569 0.339959786577771 no 2242 0.353246403380605 3125 779312 SGTC_420 mitomycin C 81.9 mM -0.377717707856393 0.33951310962215 no 2243 0.352820155853768 3067 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_678 1218-2179 85.9 µM -0.37786894250566 0.339454241173458 no 2244 0.35276397757592 3136 6820081 YOR116C RPO31 SGTC_2941 9056145 11.23 µM -0.378514802628712 0.339202882678581 no 2245 0.352524099720458 3115 2119517 SGTC_1376 2910-0861 41.3 µM -0.379214366272282 0.338930704341893 no 2246 0.352264342081873 3076 1112859 SGTC_3089 9117425 49.47 µM -0.37992333589976 0.338654952192498 no 2247 0.352001162168494 3131 9401657 SGTC_1870 st057514 26.5 µM -0.380225662644692 0.338537389171039 no 2248 0.351888955601537 3046 5393161 SGTC_2936 9038235 15.59 µM -0.380460550010644 0.338446061540281 no 2249 0.351801787615492 3032 4749415 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.38268454297488 0.337581812202953 no 2250 0.350976838275486 3062 88881 An O-methylated flavonoid and antioxidant. SGTC_1932 st074806 40.9 µM -0.383103302553798 0.337419176780751 no 2251 0.350821585508968 3312 17251235 SGTC_2978 9011784 42.97 µM -0.384027668031209 0.337060284602481 no 2252 0.350478970385739 3164 2994934 SGTC_2431 5490079 200 µM -0.385169549355558 0.336617144898889 no 2253 0.350055901150949 3137 5722345 SGTC_914 3820-6779 408 µM -0.386460514675203 0.336116422028035 no 2254 0.349577820083378 3037 2893481 SGTC_346 4513-0042 7.16 µM -0.386834558524755 0.335971397022049 no 2255 0.349439345563267 3037 2827372 SGTC_1754 st042065 16.137 µM -0.386923017519383 0.335937103098535 no 2256 0.349406600147513 3170 1126236 YIL048W NEO1 SGTC_1347 1493-0251 600 nM -0.389383763004489 0.33498366573748 no 2257 0.348496140707658 3208 3986378 SGTC_3227 9130768 49.47 µM -0.389679508252834 0.334869148056226 no 2258 0.348386775539184 3087 17720899 SGTC_1412 3909-8563 178 µM -0.390071025054973 0.334717569588779 no 2259 0.348242013898644 3206 23767530 SGTC_2943 9068529 45.32 µM -0.391199027932772 0.334281006020016 no 2260 0.347825063384682 3105 3270634 SGTC_1074 carmofur 3.8 µM -0.39177063747237 0.33405986522226 no 2261 0.347613846096933 3094 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_108 0509-0257 621.132 µM -0.393492384628273 0.333394114533568 no 2262 0.346977923754277 3132 536624 SGTC_949 1165-0505 146 µM -0.39370879199042 0.333310473018158 no 2263 0.346898024755559 3096 6244267 SGTC_3245 9134821 49.47 µM -0.394169072386015 0.33313260206178 no 2264 0.346728108894835 3113 17014901 SGTC_892 0929-0076 29 µM -0.394451070295054 0.333023645204237 no 2265 0.3466240225385 3113 5751038 SGTC_1257 0669-0121 16 µM -0.394542130788899 0.332988464743321 no 2266 0.346590414283014 3167 4307855 SGTC_535 2293-4129 48.2 µM -0.394591515262371 0.33296938607938 no 2267 0.346572188157175 3243 396118 YIL048W NEO1 SGTC_39 0986-0283 58.349 µM -0.395286054853776 0.332701110978084 no 2268 0.346315894907485 3281 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2371 9071574 200 µM -0.395875827521857 0.332473370718624 no 2269 0.346098317111695 3208 45596039 SGTC_2442 5158906 48.48 µM -0.396570932172195 0.332205035974921 no 2270 0.345841945659819 3225 1893835 SGTC_3298 9116858 71.43 µM -0.39708541472198 0.332006483064998 no 2271 0.345652237517948 3231 2506942 SGTC_1358 1509-0022 2.48 µM -0.397575209875828 0.331817501517319 no 2272 0.345471668510008 3166 3258434 SGTC_1607 st000305 50.6 µM -0.398595473932377 0.331423982379731 no 2273 0.345095648555561 3231 5457690 SGTC_706 4262-0057 46.9 µM -0.399127224291009 0.331218958268931 no 2274 0.344899731693223 3090 883298 SGTC_2990 9074105 71.4286 µM -0.399235971331631 0.331177035488853 no 2275 0.344859670306359 3173 6502001 SGTC_629 3448-6466 76.7 µM -0.399489257899188 0.331079399867893 no 2276 0.344766368661135 3142 573744 SGTC_1224 0823-0416 294 µM -0.402673627781796 0.32985288685378 no 2277 0.343594168595851 3242 3598164 SGTC_2971 9092186 9.93 µM -0.403032746241704 0.329714680813691 no 2278 0.343462067378997 3061 25236400 SGTC_1198 1612-1005 86.7 µM -0.404516712108474 0.329143826138928 no 2279 0.342916395524124 3278 6998509 SGTC_1172 0370-0043 85 µM -0.405755977616038 0.328667408250292 no 2280 0.342460953770589 3241 376585 SGTC_767 0929-0023 86 µM -0.406136612419968 0.328521134485168 no 2281 0.342321112826916 3223 1204563 SGTC_2567 aureobasidin a 60 nM -0.408819132424535 0.327491017750515 no 2282 0.341336199109894 3316 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_192 3455-0609 60.9 µM -0.409522355765924 0.327221189100792 no 2283 0.341078182067211 3243 3769639 SGTC_1993 st073995 70.8 µM -0.410071404977334 0.327010580214209 no 2284 0.340876784119419 3136 3098394 SGTC_2704 st078022 71.1 µM -0.41015059695421 0.326980207637574 no 2285 0.340847739276546 3280 54697681 SGTC_748 act1.228 77.9 µM -0.410682376779578 0.326776283294748 no 2286 0.340652725510293 3115 4421505 YNR035C ARC35 SGTC_1937 st074714 47.2 µM -0.412128089954827 0.326222149870341 no 2287 0.340122770409696 3097 17250970 SGTC_473 2-arachidonoylglycerol 10 µM -0.413060056985521 0.325865135511472 no 2288 0.339781306517214 3080 5282280 An endocannabinoid. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.413180283143218 0.325819091352078 no 2289 0.339737266357193 3116 6312947 SGTC_2121 5257820 149.641 µM -0.413657880881476 0.325636207430572 no 2290 0.339562338679767 3265 791256 SGTC_33 0986-0033 35.816 µM -0.413950630369928 0.325524127191015 no 2291 0.339455131659084 3199 2848082 SGTC_1300 1094-0077 113 µM -0.414045246237998 0.325487906523591 no 2292 0.339420485408185 3140 5532636 SGTC_2435 5706476 10.6 µM -0.414918968210718 0.325153507845583 no 2293 0.339100611798551 3276 5725375 SGTC_1606 st000094 49.2 µM -0.415272241305341 0.325018339961395 no 2294 0.338971309808201 3255 1242210 SGTC_1012 4112-3522 18 µM -0.415870758992503 0.324789390172363 no 2295 0.33875228879068 3279 3112398 SGTC_2255 7941087 197.44 µM -0.416485371023404 0.324554352709077 no 2296 0.338527434951481 3278 935561 SGTC_1994 st072947 40.9 µM -0.416695656706415 0.32447395213822 no 2297 0.338450515819292 3252 5286565 YDL195W SEC31 SGTC_2887 9044784 58.44 µM -0.417433505210231 0.324191908073706 no 2298 0.33818067599493 3136 6465546 SGTC_1573 oleylamine 1.06 µM -0.41778991436245 0.324055706079175 no 2299 0.338050362757978 3143 5356789 An amine of the fatty acid oleic acid. SGTC_1711 st032263 62.8 µM -0.419507367960248 0.323399710448578 no 2300 0.337422685553007 3162 3958979 SGTC_347 4534-1311 26.2 µM -0.420556322774131 0.322999323168743 no 2301 0.337039546653427 3157 2862016 SGTC_1151 3909-8316 15.3 µM -0.420575097303745 0.322992158775113 no 2302 0.337032690648828 3261 800431 SGTC_1375 2910-0797 186 µM -0.42070252028993 0.32294353567435 no 2303 0.336986160283621 3165 742508 SGTC_721 1187-1332 279 µM -0.42109326134614 0.322794452389681 no 2304 0.336843491032145 3093 25730 SGTC_1438 4092-1045 4 µM -0.421435646069889 0.322663842378936 no 2305 0.33671849717155 3156 1351342 SGTC_2377 9073351 62.6 µM -0.422502095446068 0.322257162598217 no 2306 0.336329285774391 3124 7337946 YHR072W ERG7 SGTC_633 0437-0093 97.7 µM -0.424901536006302 0.321342938086407 no 2307 0.335454227446214 3170 2831118 SGTC_1920 st075728 45.7 µM -0.425204000951971 0.321227770832207 no 2308 0.33534398390557 3309 3400306 SGTC_2805 7950783 58.44 µM -0.425522428277652 0.321106544279273 no 2309 0.335227937657338 3249 1178958 YDL195W SEC31 SGTC_3049 9092223 49.47 µM -0.425603350319259 0.321075739972546 no 2310 0.335198449291059 3225 8623917 SGTC_2103 5378138 10 µM -0.42586706915009 0.320975359605666 no 2311 0.335102355977954 3253 244142 SGTC_561 1550-0330 72.9 µM -0.425934850232508 0.320949561930861 no 2312 0.3350776597927 3153 6812934 SGTC_615 k087-0205 167 µM -0.426198773683787 0.320849120142855 no 2313 0.33498150550123 3167 9642773 SGTC_1708 st033234 31.827 µM -0.426807404568179 0.320617542462638 no 2314 0.334759806415115 3276 674664 SGTC_834 0312-0008 75.7 µM -0.42685642236956 0.320598894738521 no 2315 0.334741953759856 3185 6385573 YIL048W NEO1 SGTC_1706 st031321 9.9705 µM -0.42834983671198 0.320030975948083 no 2316 0.334198220141337 3258 6103185 SGTC_1212 0520-0165 585 µM -0.428475255532838 0.319983300577396 no 2317 0.334152572519279 3510 5403258 SGTC_2965 9082772 38.63 µM -0.428755775219469 0.319876677582182 no 2318 0.334050483033455 3337 16459634 SGTC_1408 3909-7976 48.8 µM -0.429920616600789 0.31943409116827 no 2319 0.333626693910155 3209 24152374 SGTC_2845 9003024 42.97 µM -0.431538357077794 0.318819850403109 no 2320 0.333038484443707 3362 2990173 SGTC_2461 5755302 26.15 µM -0.431776659800126 0.318729411100684 no 2321 0.332951872374722 3284 2788904 SGTC_1875 nocodazole 6 µM -0.431816051951038 0.318714462253805 no 2322 0.332937555999518 3293 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_919 tnp00227 403.569 nM -0.434017528860666 0.317879497797818 no 2323 0.332137856072829 3162 1269246 A methoxyflavone. YNL221C POP1 SGTC_1805 st050013 60.3 µM -0.434195247455201 0.317812133933606 no 2324 0.332073331981868 3180 4037144 SGTC_511 blebbistatin 171 µM -0.435747283850908 0.317224094216205 no 2325 0.331510047647104 3323 3476986 A myosin inhibitor. SGTC_294 k038-0071 157 µM -0.435982079875593 0.317135174190859 no 2326 0.331424865692443 3225 24152826 SGTC_2899 9053889 58.44 µM -0.436618534834382 0.316894194292427 no 2327 0.331194009233934 3275 6470052 SGTC_538 2922-0838 53.3 µM -0.438289983165659 0.316261706523072 no 2328 0.330588043128972 3331 777039 SGTC_1166 k206-0078 225 µM -0.439239119913246 0.315902785522495 no 2329 0.330244140983737 3175 5404595 SGTC_2783 7738165 71.43 µM -0.441502513081355 0.315047572246499 no 2330 0.329424621285468 3220 17201110 SGTC_825 1988-2224 89.6 µM -0.443620397548993 0.314248235602986 no 2331 0.328658527978905 3184 1180859 SGTC_1287 0971-0001 34.6 µM -0.443924614896137 0.314133488621595 no 2332 0.32854854376465 3234 4665869 SGTC_573 3702-0553 84.7 µM -0.444567991255595 0.313890874279429 no 2333 0.328315991746255 3202 1222756 SGTC_3326 9140064 16.379 µM -0.444697332361052 0.313842110035633 no 2334 0.328269248699734 3143 1868434 SGTC_1312 1218-2183 165 µM -0.445833070453383 0.313414053235253 no 2335 0.327858915753521 3291 6744073 SGTC_1559 coumarin 343 70.1 µM -0.446044773125823 0.313334290795243 no 2336 0.327782452253269 3326 108770 A hepatotoxic, DNA x-linker. SGTC_1809 st050081 57.6 µM -0.448710670493236 0.312330618605953 no 2337 0.326820193084963 3348 5036894 SGTC_509 pifithrin 175 µM -0.450500750310076 0.31165745914921 no 2338 0.326174706646244 3308 4817 A p53 inhibitor. SGTC_2329 6138490 200 µM -0.450926006610812 0.311497633897976 no 2339 0.326021439533558 3336 720019 SGTC_691 1548-0686 185 µM -0.451749425305598 0.311188267149316 no 2340 0.325724753815303 3214 46495133 SGTC_530 4358-1714 28 µM -0.451918688134111 0.311124689903352 no 2341 0.325663780448223 3266 1564641 SGTC_2967 9089538 49.85 µM -0.452524615820849 0.310897142053183 no 2342 0.325445546009159 3374 728216 SGTC_1337 1486-1011 40.3 µM -0.453517667568814 0.310524371408705 no 2343 0.325088012127266 3297 X1337 SGTC_3038 9091290 49.47 µM -0.455202946369057 0.309892198589107 no 2344 0.324481620505553 3348 25236843 SGTC_861 0443-0273 110 µM -0.455637573127516 0.309729254747876 no 2345 0.324325309868527 3289 6149169 SGTC_2154 5570129 200 µM -0.456286737841831 0.309485949126303 no 2346 0.324091899722171 3298 673366 SGTC_2885 9057732 51.95 µM -0.456902110679212 0.309255385703871 no 2347 0.323870703421868 3348 6471414 SGTC_2076 5212012 200 µM -0.457401040728225 0.309068505335417 no 2348 0.323691408227047 3237 604802 SGTC_317 4495-0002 170 µM -0.458972047057035 0.308480388494755 no 2349 0.323127119753974 3241 15991618 SGTC_79 0052-0007 94.094 µM -0.459809553690035 0.308167062796122 no 2350 0.322826462575513 3350 2801472 SGTC_1030 k029-0042 36.7 µM -0.461412977104836 0.307567584394913 no 2351 0.322251171419909 3254 6080581 SGTC_401 neomycin 50 µM -0.461845952256134 0.307405794214545 no 2352 0.322095897478892 3234 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2404 5161160 200 µM -0.462186370961248 0.307278615984588 no 2353 0.321973838014164 3223 2831543 SGTC_2750 bromebric acid 70.15 µM -0.463276074032388 0.306871665825238 no 2354 0.32158324666834 3334 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2382 9035899 200 µM -0.463372715833219 0.306835586372637 no 2355 0.321548616054378 3212 6462679 SGTC_1822 st052468 42 µM -0.4645318326783 0.306402997133643 no 2356 0.321133379146313 3271 2873678 SGTC_387 norethindrone acetate 66.7 µM -0.464901165076719 0.306265216729686 no 2357 0.321001118072991 3239 541197 SGTC_2049 5262831 67.185 µM -0.465508951464541 0.306038540086729 no 2358 0.320783514036246 3270 763417 SGTC_2373 9071805 200 µM -0.465588403700179 0.306008913507397 no 2359 0.320755072525827 3363 10149009 SGTC_2 0422-0095 29 µM -0.466824573866105 0.305548127258024 no 2360 0.320312696403766 3241 6790840 SGTC_72 0744-0168 198.391 µM -0.467440647028929 0.305318598964974 no 2361 0.320092323584775 3133 677577 SGTC_47 0149-0135 24.25 µM -0.467738815890784 0.305207538675718 no 2362 0.319985689696556 3207 5239155 SGTC_2756 carbadox 75.1 µM -0.469341742400242 0.304610796999365 no 2363 0.319412691429383 3231 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3336 9143619 71.43 µM -0.469445091794198 0.304572339630901 no 2364 0.319375761888431 3345 45595730 SGTC_2619 obliquin 87.91 µM -0.470665713439342 0.304118297312324 no 2365 0.318939736299943 3237 6708593 A bioactive alkalod. YER133W GLC7 SGTC_81 0411-0046 9.971 µM -0.475030141514309 0.302497306825536 no 2366 0.317382744813656 3269 12925265 SGTC_429 1112-0049 25.5 µM -0.476639881966393 0.301900413113173 no 2367 0.316809289428729 3174 2836170 SGTC_1426 4048-4480 71.7 µM -0.477410459782445 0.301614869347586 no 2368 0.316534933688926 3338 14224343 SGTC_885 0865-0106 16.8 µM -0.478232888974059 0.301310245726065 no 2369 0.316242228167145 3228 2793380 SGTC_2203 7227154 166.4 µM -0.478681408023879 0.301144174934111 no 2370 0.316082647109112 3322 896304 SGTC_1138 3761-0006 1.03 µM -0.479408429151186 0.300875072284971 no 2371 0.315824049047432 3336 12061087 SGTC_2832 7992762 51.95 µM -0.482700564589807 0.299657867365665 no 2372 0.314654181156218 3135 2985177 SGTC_2341 7987486 176.74 µM -0.483515815698195 0.299356788631752 no 2373 0.314364766383733 3369 1258686 SGTC_2045 5106652 78.05 µM -0.486014950124702 0.298434694449743 no 2374 0.313478283115843 3343 673349 SGTC_1750 st081859 2.357 µM -0.486192772727027 0.298369133340709 no 2375 0.313415247530041 3360 5291695 SGTC_377 3970-0964 33.1 µM -0.486230255170564 0.298355314839737 no 2376 0.313401961231762 3307 16481235 SGTC_2407 paclitaxel 400 µM -0.486623198940698 0.298210467386348 no 2377 0.313262690116272 3399 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2263 7948595 193.29 µM -0.486993208293898 0.298074103332456 no 2378 0.313131571991447 3298 2971371 SGTC_781 4335-2806 94.4 µM -0.487334291460968 0.297948424971674 no 2379 0.313010725201712 3368 845254 SGTC_2951 9072950 58.06 µM -0.489731361298494 0.29706586278724 no 2380 0.312162003368014 3353 16488155 SGTC_1656 st012921 11 µM -0.490140975032944 0.29691516934342 no 2381 0.312017072429684 3318 6732821 SGTC_1834 st055981 52.8 µM -0.490476695086326 0.296791686850317 no 2382 0.31189830850167 3402 471719 YDL150W RPC53 SGTC_2638 epoxomicin 18 µM -0.490823759497933 0.296664056463612 no 2383 0.31177555196377 3342 9915668 A protesome inhibitor. SGTC_122 0236-0016 402.397 µM -0.491620716824213 0.296371076435369 no 2384 0.311493747641478 3335 6808838 SGTC_3228 9131799 49.47 µM -0.491678305408025 0.296349910673969 no 2385 0.311473388577925 3309 17015818 SGTC_297 0986-0032 24 µM -0.492355049169611 0.296101236287637 no 2386 0.311234185244615 3274 2847425 SGTC_1986 st071812 45 µM -0.494547349645571 0.295296317950909 no 2387 0.310459837550965 3344 11838594 SGTC_864 0469-0573 172 µM -0.495580470754378 0.294917349772207 no 2388 0.310095217083378 3285 689425 SGTC_529 4076-0302 30.3 µM -0.498200220863182 0.293957382526277 no 2389 0.309171463402058 3273 5816522 SGTC_2586 curcumin 80 µM -0.49843813678032 0.293870273501819 no 2390 0.309087631151503 3363 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2813 7971799 71.43 µM -0.499858992862619 0.293350299018599 no 2391 0.308587184199791 3350 2234054 SGTC_531 3788-1495 174 µM -0.499904350464699 0.293333707039096 no 2392 0.308571214416096 3224 2896655 SGTC_2679 rapamycin 1 nM -0.504372034980103 0.291701546913638 no 2393 0.306999982877365 3359 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1659 st012954 42.1 µM -0.505730220476351 0.291206207080447 no 2394 0.306523025093905 3388 24207262 SGTC_1802 st050112 57.9 µM -0.505946700843284 0.291127291462506 no 2395 0.306447033323474 3334 4662563 SGTC_443 clozapine 122 µM -0.506676720030752 0.290861244377094 no 2396 0.306190833809035 3348 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.50698394418979 0.290749314058212 no 2397 0.306083042114327 3340 91467 include heat shock SGTC_734 2023-0417 80 µM -0.507014241591399 0.290738276962058 no 2398 0.306072412973327 3368 3935732 SGTC_3312 9133330 71.43 µM -0.507606372421891 0.290522607876975 no 2399 0.305864710385538 3391 17617324 SGTC_1629 st005085 44.9 µM -0.508501079385368 0.29019687498654 no 2400 0.305550991160721 3260 24207091 SGTC_604 1000-0114 314 µM -0.509286050677679 0.289911234174618 no 2401 0.3052758670619 3406 1572745 SGTC_1294 1000-1494 117 µM -0.509598447276508 0.289797593818333 no 2402 0.305166405955668 3327 712797 YDL207W GLE1 SGTC_3229 9132204 49.47 µM -0.510473792465326 0.289479281303207 no 2403 0.304859785300857 3309 17682924 SGTC_2908 7930301 100 µM -0.513393445656154 0.288418761034981 no 2404 0.303838064742123 3286 2223178 SGTC_197 4544-0043 41.561 µM -0.516564065747077 0.287269159389386 no 2405 0.302730252873066 3367 896523 SGTC_1068 loratadine 26.9 µM -0.520021466868745 0.286018053822332 no 2406 0.301524306545691 3337 3957 A H1 histamine antagonist. SGTC_987 1497-1013 404 µM -0.520454443348423 0.285861558278575 no 2407 0.301373436158806 3400 1676435 SGTC_1661 st013063 9.66 µM -0.52098491455022 0.285669879640515 no 2408 0.301188640135922 3343 721395 SGTC_813 k007-0158 173 µM -0.52149140470642 0.285486923317716 no 2409 0.301012245852166 3352 6523916 SGTC_15 0266-0086 27.098 µM -0.521584036776979 0.285453468439955 no 2410 0.300979990109792 3435 1712902 YIL048W NEO1 SGTC_1511 0906-3109 28.5 µM -0.524664851063122 0.284341870411221 no 2411 0.299908097877204 3407 2882180 SGTC_1760 st045453 10.4495 µM -0.525848994684729 0.283915166995477 no 2412 0.299496564915977 3418 3323419 YIL048W NEO1 SGTC_2736 butenafine 14.65 µM -0.526846288318414 0.283556032449317 no 2413 0.299150167831223 3315 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_406 estrone 100 µM -0.527911834606651 0.283172560195656 no 2414 0.298780265134678 3444 5870 A steroid. SGTC_1256 0570-0116 285 µM -0.529572001031074 0.282575590409198 no 2415 0.298204355647384 3344 410638 SGTC_2242 6630449 61.2675 µM -0.529577238551682 0.282573708036724 no 2416 0.298202539558819 3413 691249 YDR170C SEC7 SGTC_1448 4255-0083 152 µM -0.531374304761491 0.281928195972822 no 2417 0.297579711912909 3458 5399660 SGTC_703 3875-0075 71.8 µM -0.531557061800869 0.281862588863208 no 2418 0.297516405211145 3390 2850814 SGTC_1188 1403-0014 4.57 µM -0.531608412819379 0.281844155921106 no 2419 0.297498618419591 3354 9614867 SGTC_646 4092-0839 27.3 µM -0.533885878962279 0.281027222279576 no 2420 0.296710246218774 3475 877796 SGTC_3309 9129340 25.759 µM -0.53433899037207 0.280864826477657 no 2421 0.296553510440415 3365 17158987 SGTC_2152 5568786 200 µM -0.534833830677022 0.280687526820461 no 2422 0.29638238356573 3380 5399883 SGTC_2092 5303694 80.6725 µM -0.536048212089702 0.28025264754467 no 2423 0.295962615228938 3338 1963699 SGTC_2113 5491891 107.031 µM -0.53675899293828 0.27999826299479 no 2424 0.295717050348314 3371 789979 SGTC_3002 9075603 71.4286 µM -0.537560660105802 0.279711485129383 no 2425 0.295440197916591 3433 20105405 SGTC_526 4469-0568 170 µM -0.537877918153576 0.279598032786883 no 2426 0.295330667102113 3385 2901964 SGTC_255 tunicamycin 200.472 nM -0.538063093682118 0.279531823839017 no 2427 0.295266745362833 3371 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1048 3161-0300 24.5 µM -0.538328189658411 0.279437052829486 no 2428 0.29517524653831 3431 2165101 SGTC_1189 1431-2119 7.28 µM -0.539820561078721 0.278903825965361 no 2429 0.294660392983371 3463 3107275 SGTC_159 3970-0959 50 µM -0.542580695785933 0.27791893153555 no 2430 0.293709266602131 3517 6615653 SGTC_2513 baicalein 25.65 µM -0.542843905709167 0.2778250994928 no 2431 0.293618640248918 3367 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3291 9121177 71.43 µM -0.544718888140937 0.2771571324871 no 2432 0.292973436066593 3357 17015612 SGTC_3345 9148410 3.559 µM -0.544856053782318 0.277108297758313 no 2433 0.292926261541293 3439 4903596 SGTC_221 trifluoperazine 10.304 µM -0.546117844365374 0.276659263348401 no 2434 0.292492467221952 3446 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_709 3807-1509 243 µM -0.546384616744721 0.27656437253569 no 2435 0.292400791091564 3447 1886677 YPL242C IQG1 SGTC_2269 7935389 174.42 µM -0.547322036301315 0.276231059416907 no 2436 0.292078753556063 3403 97605 SGTC_1670 st016595 4.04 µM -0.5486156510303 0.275771419896341 no 2437 0.291634621391785 3423 597879 SGTC_2194 5927483 104.545 µM -0.549016890827523 0.275628930159658 no 2438 0.291496929150493 3428 760979 SGTC_2587 piperic acid 92.2 µM -0.549296247632391 0.275529745334098 no 2439 0.291401081032823 3337 5370536 SGTC_2025 5147754 141 µM -0.550529480090571 0.275092099625797 no 2440 0.290978131290453 3416 315777 YLR208W SEC13 SGTC_1548 st061468 90.8 µM -0.550784059728092 0.275001797845032 no 2441 0.290890856318607 3412 390799 SGTC_314 1671-0008 2.74 µM -0.553720771475986 0.273961175798504 no 2442 0.289884978759045 3383 3913060 SGTC_599 1935-0052 86.5 µM -0.553732507585723 0.273957021022877 no 2443 0.289880962201264 3346 9557311 SGTC_3066 9117245 49.47 µM -0.554320764502657 0.273748808324021 no 2444 0.289679671027378 3390 17176980 SGTC_1041 0206-0046 107 µM -0.554837331643441 0.273566034684718 no 2445 0.289502964950306 3383 50494 SGTC_1264 0783-0040 158 µM -0.558850670556531 0.27214808137051 no 2446 0.288131818898221 3370 2855798 SGTC_194 1486-1323 56.904 µM -0.55994531409454 0.271761967814868 no 2447 0.287758369532351 3424 5178754 SGTC_2765 myclobutanil 7.74 µM -0.561197636928966 0.271320570679495 no 2448 0.287331406853693 3471 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_649 1123-0311 367 µM -0.561818317066672 0.27110193656024 no 2449 0.28711990543108 3439 693629 YIL048W NEO1 SGTC_3030 9087619 49.47 µM -0.562328375171325 0.270922334762649 no 2450 0.286946154492541 3413 25236973 SGTC_2910 7948405 25.97 µM -0.563522233397028 0.27050218533571 no 2451 0.28653966238015 3454 2971328 SGTC_73 0327-0325 16.231 µM -0.566577874155044 0.269428311822558 no 2452 0.285500505458932 3485 53298 SGTC_2187 6125751 200 µM -0.569379410806987 0.268445622069641 no 2453 0.284549343144135 3444 874498 SGTC_2771 fluoxetine 41.05 µM -0.57001682006625 0.268222291143734 no 2454 0.284333144980253 3507 3386 A selective serotonin reuptake inhibitor. SGTC_998 3996-0085 177 µM -0.571312917680627 0.26776846216871 no 2455 0.28389377342733 3422 715391 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.573510925502064 0.266999714487595 no 2456 0.283149401865782 3341 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1766 st045414 44.774 µM -0.573585710544525 0.26697357822834 no 2457 0.283124091841652 3498 253960 SGTC_3148 9097893 49.47 µM -0.573814628593038 0.26689358280989 no 2458 0.283046624256264 3361 17174100 SGTC_1534 6-azauridine 81.6 µM -0.574571416233996 0.266629209564943 no 2459 0.282790594077264 3445 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1679 SEC14.276 6.7 µM -0.57517873036651 0.266417148614841 no 2460 0.282585213043486 3454 1005053 YMR079W SEC14 SGTC_153 4077-0274 519.67 µM -0.575714778989886 0.266230042961398 no 2461 0.282403992122076 3598 3121976 SGTC_1857 st056007 79.3 µM -0.578592396024944 0.265226760415197 no 2462 0.281432118364334 3495 619834 SGTC_2976 9009005 19.48 µM -0.57863346830152 0.265212454454283 no 2463 0.281418258483967 3527 2993148 SGTC_2135 5326629 150.42 µM -0.578697144808079 0.265190275946684 no 2464 0.281396771435024 3422 5020077 SGTC_63 0099-0242 26.702 µM -0.578700797817853 0.265189003633072 no 2465 0.281395538784633 3497 3898502 YLR359W ADE13 SGTC_2257 7960413 200 µM -0.579934997224196 0.264759319524807 no 2466 0.280979226944013 3455 2974689 YIL048W NEO1 SGTC_3275 9138069 49.47 µM -0.580430141611532 0.264587035526542 no 2467 0.280812291868956 3491 17617007 SGTC_1866 st057638 64 µM -0.581294707149341 0.264286349343883 no 2468 0.280520923604565 3437 688802 SGTC_1056 3448-1962 115 µM -0.582045554923787 0.264025354164032 no 2469 0.280267998272584 3463 715507 SGTC_3342 9147791 14.508 µM -0.582421337404388 0.26389478126001 no 2470 0.280141456301933 3473 1838168 SGTC_59 0330-0160 1.33 µM -0.584284243343671 0.263247964952277 no 2471 0.279514545660475 3506 4293482 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.584984606878328 0.263005002563511 no 2472 0.279279033562568 3496 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2298 7976326 193.81 µM -0.585490901677387 0.262829435762935 no 2473 0.279108841266396 3405 2235818 SGTC_774 k060-0086 136 µM -0.585966834748822 0.262664452104349 no 2474 0.278948901138399 3532 5911235 SGTC_2734 clemastine 41.6 µM -0.586171139890225 0.262593645359503 no 2475 0.278880256865497 3427 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1769 st044406 64.4 µM -0.592181350544713 0.260515045054945 no 2476 0.276864578173001 3433 670903 SGTC_1453 4237-0541 195 µM -0.5952310312705 0.259463578171103 no 2477 0.275844525159079 3495 739892 SGTC_2689 tacrolimus 100 µM -0.597248293149766 0.25876927438554 no 2478 0.275170810372747 3479 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2817 7995342 71.43 µM -0.598174948306495 0.258450659624646 no 2479 0.274861602632307 3402 18879975 SGTC_669 0108-0021 26.2 µM -0.598462379190805 0.258351872668186 no 2480 0.274765727054932 3658 17201 SGTC_482 fipronil 114 µM -0.598729912521559 0.25825994187448 no 2481 0.274676503332437 3537 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2217 6934799 96.0675 µM -0.598854446641928 0.258217154782762 no 2482 0.274634975445881 3486 675606 SGTC_2808 7946468 45.46 µM -0.599645763236406 0.25794536227868 no 2483 0.274371170697647 3487 2970879 SGTC_299 1273-0059 1.44 µM -0.600244179384189 0.257739923644348 no 2484 0.274171757132673 3509 2848077 SGTC_2977 9011197 71.43 µM -0.600406763993787 0.257684122379943 no 2485 0.274117590522462 3558 2704722 SGTC_836 0330-0104 1.35 µM -0.600665684175951 0.257595270377448 no 2486 0.274031339714459 3518 46494820 SGTC_179 1273-0063 6.77 µM -0.601599984394634 0.257274784812984 no 2487 0.273720219642481 3450 3108139 SGTC_1588 farnesol 29.9 µM -0.60312606780878 0.256751750662379 no 2488 0.273212413040837 3551 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1999 st074831 12.5 µM -0.605268276622054 0.256018486977431 no 2489 0.272500378113559 3441 17112523 SGTC_2683 piperine 63.03 µM -0.605613262000808 0.255900503015118 no 2490 0.27238579685686 3460 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1419 3993-2473 62.6 µM -0.606333694070094 0.255654208940011 no 2491 0.272146594313852 3524 704026 SGTC_682 0kpi-0099 17 µM -0.607240969708892 0.255344214866128 no 2492 0.271845503382196 3550 1714895 YML126C ERG13 SGTC_2429 5902844 64.44 µM -0.607755460417923 0.255168513208124 no 2493 0.271674836787265 3501 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1431 4049-0260 9.09 µM -0.608454974782635 0.254929726320441 no 2494 0.271442879834577 3516 3854841 SGTC_1386 3228-0095 33.8 µM -0.608611524031056 0.254876302538131 no 2495 0.271390982068043 3523 870181 SGTC_893 0958-0369 48.9 µM -0.608614928767281 0.254875140707615 no 2496 0.271389853416149 3515 6819948 SGTC_217 ketoconazole 989 nM -0.609925761837202 0.254428038725215 no 2497 0.270955493109095 3496 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2283 7944793 200 µM -0.612531554068742 0.253540471204005 no 2498 0.270093063889788 3515 2970533 SGTC_332 4112-0506 40.9 µM -0.613453859252287 0.253226712005522 no 2499 0.269788141408094 3527 2790355 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.613698332616129 0.253143578805324 no 2500 0.269707345201678 3564 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2523 spermine 47.74 µM -0.614889403016413 0.25273876057828 no 2501 0.26931388078744 3515 1103 A DNA binding polyamine. SGTC_2438 5259590 200 µM -0.615424384656571 0.252557043271939 no 2502 0.269137245888178 3501 1201127 SGTC_3265 9137266 49.47 µM -0.616071611854597 0.252337291543361 no 2503 0.268923628598865 3503 17224265 SGTC_1267 0828-0272 9.49 µM -0.616177646101483 0.252301299564014 no 2504 0.268888640120664 3604 745334 SGTC_2082 5219693 150 µM -0.617530430166681 0.251842351821067 no 2505 0.26844245810048 3546 2834649 SGTC_1935 st074532 41.6 µM -0.617807248137618 0.251748492449937 no 2506 0.268351202513942 3606 2829742 SGTC_1181 1222-0449 220 µM -0.618915770979575 0.251372815973736 no 2507 0.267985924190877 3620 658318 SGTC_778 3456-2434 196 µM -0.620517542171152 0.250830502388719 no 2508 0.267458554225184 3544 5539063 SGTC_871 0574-0004 149 µM -0.620836064906635 0.250722733645623 no 2509 0.267353745662617 3483 9551173 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.620968463317852 0.250677945281987 no 2510 0.267310186620881 3476 390807 SGTC_54 0159-0055 9 µM -0.621304136623649 0.250564411114593 no 2511 0.267199766243434 3632 3319099 SGTC_1956 st077085 54 µM -0.62232028820736 0.250220886152221 no 2512 0.266865641622409 3528 24208685 SGTC_1458 k015-0034 6.33 µM -0.622721201553565 0.250085420250758 no 2513 0.266733873894771 3514 3598957 SGTC_127 0180-0333 59.125 µM -0.623490738330657 0.24982550804338 no 2514 0.26648104330155 3552 771601 SGTC_16 erodoxin 22.806 µM -0.624058663122546 0.249633782599176 no 2515 0.266294529913693 3588 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_594 1487-1584 10.8 µM -0.624554887885836 0.249466326330916 no 2516 0.266131617786016 3504 5013332 SGTC_754 3474-0146 171 µM -0.624648671158305 0.249434684887159 no 2517 0.26610083411821 3479 24762078 SGTC_1131 3454-3128 32.3 µM -0.625016249925933 0.249310688423253 no 2518 0.265980196484347 3540 710982 SGTC_7 0192-1582 4.227 µM -0.62617109039662 0.248921335884495 no 2519 0.265601363586264 3593 252616 SGTC_1382 3002-2117 298 µM -0.627165110485768 0.248586463008541 no 2520 0.265275505357854 3616 1497314 SGTC_1944 st076371 56.9 µM -0.630331431313047 0.247521371076947 no 2521 0.264238881324123 3479 24208455 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.630671281573609 0.247407196788312 no 2522 0.264127740220909 3582 279621 SGTC_1146 3579-1023 7 µM -0.630910237082931 0.247326935420802 no 2523 0.264049608951328 3582 X1146 SGTC_2261 9010538 184.68 µM -0.631109894572915 0.247259884310164 no 2524 0.263984335984743 3515 6457250 SGTC_2262 9014885 67.46 µM -0.632793336524986 0.246694919517985 no 2525 0.263434304384713 3517 6457424 SGTC_1399 3562-5772 25 µM -0.63422168985339 0.246216105351964 no 2526 0.2629680771831 3526 23847490 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.634964676817795 0.245967237611593 no 2527 0.26272572651988 3589 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2703 st077852 53.4 µM -0.637347163524197 0.245170121213323 no 2528 0.261949368170178 3573 6281836 SGTC_2565 isoliquiritigenin 100 µM -0.637622357778956 0.245078138145221 no 2529 0.261859769069385 3526 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3037 9091026 49.47 µM -0.639273982651053 0.244526476423478 no 2530 0.261322355352854 3591 25236398 YIL048W NEO1 SGTC_2541 muurolladie-3-one 83.07 µM -0.639523526117855 0.244443184240162 no 2531 0.261241206983676 3603 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2946 9065502 71.43 µM -0.639583132212484 0.244423291283843 no 2532 0.26122182575383 3425 16489101 SGTC_2274 7947094 46.08 µM -0.641996282321033 0.243618658852816 no 2533 0.260437798430229 3596 2971028 SGTC_1230 0170-0365 3.77 µM -0.642463739138356 0.243462957213331 no 2534 0.260286062949996 3654 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2353 9059630 146.67 µM -0.642545587552023 0.243435700478796 no 2535 0.260259499817233 3583 4779114 SGTC_558 k064-0027 21.3 µM -0.643160952922907 0.243230827495934 no 2536 0.260059833514965 3575 5088526 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.644382176816625 0.242824522815655 no 2537 0.259663819602558 3568 6708561 SGTC_3208 9114115 49.47 µM -0.644734718323434 0.242707299605775 no 2538 0.25954955669124 3537 650895 SGTC_3356 9151811 4.48 µM -0.64568696939967 0.242390820774386 no 2539 0.259241050576574 3565 1859254 YPR165W RHO1 SGTC_1204 4049-0315 18.3 µM -0.646487823561298 0.242124831607814 no 2540 0.258981740163693 3620 588402 SGTC_1865 st057639 52.2 µM -0.646926508314675 0.241979197548001 no 2541 0.258839754309205 3597 688818 SGTC_2556 citropten 84.59 µM -0.647430624798937 0.24181190022574 no 2542 0.258676640402144 3562 2775 A potential DNA crosslinker. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.649026248764863 0.241282786557797 no 2543 0.258160705039166 3582 97141 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.651768083170427 0.240375057382496 no 2544 0.257275397119988 3573 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1124 fisetin 1.16336 µM -0.652001814903544 0.24029776280724 no 2545 0.257200000798279 3566 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1597 7-benzyloxygramine 47.5 µM -0.652013022761531 0.240294056733288 no 2546 0.257196385697374 3577 260807 SGTC_1829 berberine 14.4 µM -0.652563360781225 0.240112116171321 no 2547 0.257018906360938 3625 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1424 4048-1941 275 µM -0.652725918907053 0.240058389175692 no 2548 0.256966494936646 3648 X1424 SGTC_625 k213-0058 121 µM -0.653107668651673 0.239932243053306 no 2549 0.256843434379512 3659 3655420 SGTC_1493 4348-0038 111 µM -0.653471071572313 0.239812193085939 no 2550 0.25672631659238 3632 800424 SGTC_1221 2958-7315 257 µM -0.654633771927371 0.239428315866223 no 2551 0.256351787448609 3600 4562705 SGTC_2552 juarezic acid 87.02 µM -0.654654322273398 0.239421533982086 no 2552 0.256345170331245 3669 1549512 SGTC_2874 9043904 71.43 µM -0.654766490521551 0.23938451883586 no 2553 0.256309054237788 3534 4463428 SGTC_351 caspofungin 25 nM -0.656168290214072 0.238922193342393 no 2554 0.255857924549702 3641 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2446 5162541 200 µM -0.656253140019814 0.238894224833215 no 2555 0.255830631340677 3573 1549321 SGTC_2642 cholecalciferol 100 µM -0.656635806492694 0.238768111133593 no 2556 0.255707559830266 3591 9821465 A vitamin D precursor, similar to steriods. SGTC_2384 9036245 200 µM -0.657500492281957 0.238483274636744 no 2557 0.25542957727409 3595 6462766 SGTC_1454 4239-0054 42.6 µM -0.657928158591528 0.238342465691145 no 2558 0.255292147832065 3702 1340767 SGTC_2859 9028643 45.46 µM -0.658290488416486 0.238223204393655 no 2559 0.255175744351277 3578 17151580 SGTC_829 1635-0120 117 µM -0.658481127528417 0.238160468429265 no 2560 0.255114510038157 3610 285054 SGTC_1987 st072290 61.9 µM -0.6588038599889 0.238054283515203 no 2561 0.255010864148581 3604 54697379 SGTC_506 n9-isopropylolomoucine 153 µM -0.659268695281297 0.237901389769161 no 2562 0.254861620501309 3608 6610355 SGTC_544 k015-0020 52.4 µM -0.659679826934262 0.237766205122655 no 2563 0.254729657472444 3606 3008304 SGTC_2470 5664817 21.68 µM -0.660228355926289 0.237585908336351 no 2564 0.2545536490421 3641 2859561 SGTC_1421 4029-0249 71.4 µM -0.660972832655651 0.237341325268432 no 2565 0.254314868122753 3686 2894095 SGTC_2585 alliin 100 µM -0.661306203975751 0.2372318475661 no 2566 0.254207981820155 3688 87310 A garlic compound which reacts with lipids. SGTC_232 clozapine 119 µM -0.661836502539829 0.237057756976801 no 2567 0.254038004790395 3577 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1686 st019653 115.5 µM -0.662478753826836 0.236847007701576 no 2568 0.253832223329803 3627 97252 SGTC_2861 9024595 19.48 µM -0.665891441543927 0.235728893249772 no 2569 0.252740245645739 3565 16482810 SGTC_2478 5763493 32.33 µM -0.665970387628017 0.235703062276323 no 2570 0.252715014110394 3592 1365576 YLR208W SEC13 SGTC_46 0329-0187a 2.197 µM -0.66719671509365 0.235302011327718 no 2571 0.252323244554944 3612 46494817 SGTC_3215 9129942 49.47 µM -0.668037766692112 0.235027176669152 no 2572 0.252054742632978 3567 17682944 SGTC_3132 9126706 49.47 µM -0.668119733064676 0.235000401592716 no 2573 0.252028583302548 3636 850858 SGTC_528 3492-0019 172 µM -0.668262007664188 0.234953930275814 no 2574 0.251983180177501 3654 2869262 SGTC_1133 3473-0247 50 µM -0.669638920768507 0.234504450026584 no 2575 0.251543998376327 3595 711311 SGTC_765 1319-0117 244 µM -0.669793906431117 0.23445388622659 no 2576 0.251494589304761 3614 3487746 YGL099W LSG1 SGTC_2669 eugenol 100 µM -0.669861996377651 0.23443167390856 no 2577 0.251472884008487 3603 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3152 9099253 49.47 µM -0.670663349350749 0.234170343867952 no 2578 0.251217508015294 3642 25236131 SGTC_2278 7948257 134.34 µM -0.670676285049978 0.234166126717084 no 2579 0.251213386778396 3601 1247028 SGTC_150 3970-0969 77.2 µM -0.670988884454282 0.234064229369983 no 2580 0.251113805338725 3657 6615640 SGTC_319 1348-1596 45.5 µM -0.672582523417863 0.233545136255024 no 2581 0.250606461615331 3683 5380505 SGTC_2416 tofa 880 nM -0.672814333499232 0.233469682403697 no 2582 0.250532708864098 3565 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2498 4'-Methoxychalcone 54.63 µM -0.673819712572965 0.233142589497244 no 2583 0.250212970364107 3570 641818 YHR062C RPP1 SGTC_1097 itavastatin 7.23 µM -0.674278292774059 0.232993478229534 no 2584 0.250067201006525 3656 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.674461466603311 0.232933932501484 no 2585 0.250008987948904 3575 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_40 0327-0103 19.753 µM -0.678168863870125 0.23173055887567 no 2586 0.248832315919571 3575 409036 SGTC_653 0203-0016 55.2 µM -0.678977651524901 0.231468497784626 no 2587 0.248576011206261 3661 295302 SGTC_1500 4488-1866 171 µM -0.67964876294641 0.231251171656198 no 2588 0.248363442891903 3701 2900003 SGTC_1514 1189-1591 158 µM -0.67983746831758 0.231190083672885 no 2589 0.2483036896749 3668 767698 YMR146C TIF34 SGTC_1403 3909-7815 62.9 µM -0.680376981786984 0.231015481249335 no 2590 0.248132895992508 3600 6615483 SGTC_245 methotrexate 289.6 µM -0.680587139623572 0.230947487919281 no 2591 0.248066383326252 3635 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3097 9117246 49.47 µM -0.680861177631142 0.230858843929389 no 2592 0.247979667571275 3671 16423892 SGTC_2213 7173844 200 µM -0.681928514940376 0.230513769938292 no 2593 0.247642076841531 3628 892728 SGTC_2267 7931562 200 µM -0.682631209393935 0.230286743760287 no 2594 0.247419953967416 3579 934880 SGTC_1479 0549-0158 134 µM -0.682878657298554 0.230206828191745 no 2595 0.247341760634319 3692 5440202 SGTC_477 mead ethanolamide 10 µM -0.683347807390661 0.230055354464537 no 2596 0.247193545865749 3533 16061185 SGTC_2280 7785178 200 µM -0.684709079627699 0.229616158546088 no 2597 0.246763759191234 3648 2954328 SGTC_2098 5376439 882.5 nM -0.685524399028722 0.229353331933063 no 2598 0.246506534775096 3700 2844116 SGTC_687 k029-0044 34.9 µM -0.685666520850042 0.229307534765487 no 2599 0.246461711591998 3676 5829338 SGTC_2041 5107442 45.335 µM -0.685891539865387 0.229235035389784 no 2600 0.246390752755753 3662 793005 SGTC_3247 9135149 49.47 µM -0.68595905757314 0.229213284216903 no 2601 0.24636946345553 3625 8934436 YOR116C RPO31 SGTC_823 0417-1665 178 µM -0.686005681212391 0.229198264849995 no 2602 0.246354762929849 3680 3429856 SGTC_64 000l-0018 272.079 µM -0.6862907031959 0.229106459699158 no 2603 0.246264905158085 3610 6811119 SGTC_3044 9093193 49.47 µM -0.687084223789513 0.228850976593806 no 2604 0.246014827598226 3636 25236277 SGTC_1207 2099-0101 141 µM -0.687262492702312 0.22879360286667 no 2605 0.245958665000734 3675 5837381 SGTC_357 1325-0123 420 µM -0.687730925132031 0.228642881957157 no 2606 0.245811120849114 3630 1098503 SGTC_760 0568-0725 82.9 µM -0.688898150212944 0.228267563045535 no 2607 0.245443681793213 3659 3916171 SGTC_1132 3456-3614 2.5 µM -0.689322890689592 0.228131074572039 no 2608 0.245310048003334 3718 3125502 SGTC_1741 st038134 10.228 µM -0.691220878842098 0.227521725494262 no 2609 0.2447133724596 3714 1272587 SGTC_1100 amiodarone 5.07 µM -0.691373370982038 0.227472807706404 no 2610 0.244665467039037 3696 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1889 st059080 5.18 µM -0.691942917171165 0.227290155992411 no 2611 0.244486588709778 3657 176925 Isolated from Daphnopsis sellowiana. SGTC_3109 9122853 49.47 µM -0.695038093068376 0.226298988770285 no 2612 0.24351571467219 3703 1234709 SGTC_2468 5987765 72.9 µM -0.695169622490405 0.226256923296909 no 2613 0.243474503584117 3693 26772094 SGTC_131 0141-0277 33.849 µM -0.697140336361134 0.225627182766133 no 2614 0.242857486549238 3630 1547771 SGTC_3036 9090181 49.47 µM -0.699627702129933 0.224833764148929 no 2615 0.242079918844077 3689 25236586 SGTC_563 tetrahydrosecaminediol 614 µM -0.699808853829694 0.224776042338503 no 2616 0.242023342359486 3710 334274 A psychoactive constituent of the cannabis plant. SGTC_859 0439-0102 54.6 µM -0.699965150884123 0.224726246915306 no 2617 0.241974534129306 3690 610143 SGTC_617 3770-0098 35 µM -0.701104077850286 0.224363579691634 no 2618 0.241619032829083 3635 5962639 SGTC_868 0527-0199 213 µM -0.702123673346493 0.224039193072025 no 2619 0.241301020012763 3646 2849450 SGTC_3135 9127742 49.47 µM -0.702353745657623 0.223966031904793 no 2620 0.241229291702077 3701 3643468 SGTC_2423 st077119 87.2 µM -0.702942395541255 0.223778907727197 no 2621 0.241045824505593 3640 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2848 9016370 25.97 µM -0.703973953364575 0.223451203277525 no 2622 0.240724497237272 3682 7894410 SGTC_2551 apiole 73.87 µM -0.70536061071208 0.22301112156588 no 2623 0.2402929250539 3560 10659 A possible DNA adduct former. SGTC_607 4491-0986 66.8 µM -0.705509396646224 0.22296393090159 no 2624 0.240246643161882 3694 698981 YDR232W HEM1 SGTC_992 3909-8734 162 µM -0.706056838995062 0.222790346740485 no 2625 0.24007639558486 3699 4288319 SGTC_220 paclitaxel 373.376 µM -0.706081568199368 0.22278250737114 no 2626 0.240068706671158 3636 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_476 mead acid 10 µM -0.706940939540819 0.222510176967036 no 2627 0.239801590543448 3703 5312531 An omega 9 fatty acid. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.707574974215833 0.222309376355778 no 2628 0.239604619211502 3735 4213774 SGTC_3324 9138759 60.749 µM -0.707938100230044 0.222194419874607 no 2629 0.239491849055831 3714 45595710 SGTC_1719 st032227 49.2 µM -0.70841849812516 0.222042390230152 no 2630 0.239342704215138 3715 3125804 SGTC_2318 6029776 164 µM -0.708681607881999 0.221959150088829 no 2631 0.239261040388284 3688 818325 SGTC_102 gallobenzophenone 83.616 µM -0.711446554367457 0.221085481020972 no 2632 0.238403779434813 3712 70837 SGTC_2754 granisetron 64.02 µM -0.712309062292069 0.22081334857493 no 2633 0.238136706768104 3678 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1177 0983-0204 23.6 µM -0.712416406071403 0.220779493645306 no 2634 0.238103479604935 3724 766818 SGTC_2666 tannic acid 100 µM -0.713160051914499 0.220545038380434 no 2635 0.237873361464774 3697 16134267 A thiamine antagonist. SGTC_1292 0kpi-0043 232 µM -0.718273738817694 0.218936673119067 no 2636 0.236294259593163 3719 3333905 SGTC_2479 5617353 43.85 µM -0.719439992031554 0.218570808341751 no 2637 0.235934931690034 3725 2731746 SGTC_1969 st069479 40.1 µM -0.71952141175432 0.218545279348585 no 2638 0.235909857155654 3670 3895485 SGTC_1557 sumaresinolic acid 42.3 µM -0.719845294233715 0.218443743637177 no 2639 0.235810126796819 3664 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2843 9000894 45.46 µM -0.721262477444819 0.217999782669472 no 2640 0.235374019196878 3608 2242070 SGTC_1983 st071813 46.9 µM -0.723586474868393 0.217272871179218 no 2641 0.234659823645244 3764 11838595 SGTC_402 epigallocatechin gallate 10 µM -0.72362511884015 0.217260795769589 no 2642 0.234647957972537 3690 65064 An antioxidant. SGTC_927 2425-1185 123 µM -0.724258329798235 0.217062986189329 no 2643 0.234453577141288 3696 730375 SGTC_1943 st076331 65.2 µM -0.724790670663525 0.216896768098042 no 2644 0.234290230007106 3757 24208415 SGTC_1830 st055982 50.3 µM -0.726988609629287 0.216211263249591 no 2645 0.233616466713207 3648 455313 An antimicrobial agent. SGTC_2000 st075254 36.4 µM -0.727875549289357 0.215934995453851 no 2646 0.233344885916392 3685 17234175 SGTC_2469 5655019 90.81 µM -0.72807027919064 0.215874367537345 no 2647 0.233285283109952 3766 2788239 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.728398064927096 0.215772335813141 no 2648 0.233184973739742 3683 5711223 A potent inhibitor of glutathione S-transferases. SGTC_4 0960-0234 25.671 µM -0.728648913529631 0.215694271631388 no 2649 0.233108224935351 3697 6821112 SGTC_1182 1222-0449 220 µM -0.728950066070836 0.215600574475984 no 2650 0.233016103833617 3706 658318 SGTC_1239 0337-0584 35.4 µM -0.72932177988703 0.215484956244022 no 2651 0.23290242626292 3767 914301 YML130C ERO1 SGTC_1818 st052136 56.3 µM -0.733040229769527 0.214330346791195 no 2652 0.231766946510523 3616 674169 SGTC_1645 Cervolide 78 µM -0.73330468506181 0.214248368520397 no 2653 0.231686309095421 3691 23173 A fragrance. SGTC_3177 9107506 49.47 µM -0.733849845548449 0.214079432256735 no 2654 0.231520128706067 3652 8897194 SGTC_1356 1502-0781 85.8 µM -0.73471674164731 0.213810955135194 no 2655 0.231256011067508 3711 567702 SGTC_943 3253-1379 105 µM -0.735448566198253 0.213584462285033 no 2656 0.231033176643326 3717 668464 SGTC_345 1362-0200 395 µM -0.735523151169018 0.213561386786992 no 2657 0.23101047287843 3730 1419823 SGTC_658 3253-0951 102 µM -0.735873937706989 0.213452878052252 no 2658 0.230903709691565 3743 1184878 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.736642755294319 0.213215172273289 no 2659 0.230669813588478 3693 2724278 An inhibitor of dopamine biosynthesis. SGTC_2475 5812728 15.03 µM -0.737815339131665 0.212852926029836 no 2660 0.230313335381515 3725 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2947 9072639 7.68 µM -0.737891125329232 0.212829525770424 no 2661 0.230290306158934 3746 16488146 SGTC_1520 flindersine 88 µM -0.738686566015883 0.212584010724923 no 2662 0.23004867255902 3815 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1981 st071826 47 µM -0.73871387794825 0.212575583757136 no 2663 0.23004037844468 3721 11838600 SGTC_3116 9124943 49.47 µM -0.738731011427407 0.212570297402621 no 2664 0.230035175418383 3673 41905195 YPL160W CDC60 SGTC_889 0919-1524 82.7 µM -0.738963585270501 0.212498546788607 no 2665 0.229964554840043 3777 3905452 SGTC_641 4092-0595 30 µM -0.74061784957638 0.211988603336694 no 2666 0.229462591081377 3781 786260 SGTC_2514 salinomycin 42.74 µM -0.741606668143645 0.211684132236651 no 2667 0.229162841132782 3830 23682228 A polyether potassium ionophore. SGTC_3176 9106582 49.47 µM -0.741796665834156 0.211625658612051 no 2668 0.229105270493584 3630 17018027 SGTC_479 n-linoleoylglycine 10 µM -0.742000791612982 0.211562847468741 no 2669 0.229043427984894 3768 6433346 An anti-infammatory. SGTC_2865 9030313 51.95 µM -0.742137614998761 0.211520751923301 no 2670 0.22900198083768 3687 42562754 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.746109191958101 0.210300981839078 no 2671 0.227800728546666 3794 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3252 9135871 49.47 µM -0.746360745320314 0.21022386288411 no 2672 0.22772476274247 3761 17682838 SGTC_2120 5538279 151.968 µM -0.746770082760427 0.210098407422199 no 2673 0.227601178708977 3753 2058197 SGTC_3069 9117009 49.47 µM -0.747563685104642 0.209855306168796 no 2674 0.227361687960205 3675 41904981 SGTC_1385 3091-4834 14.1 µM -0.74840231608172 0.209598591229406 no 2675 0.227108762975305 3731 4072814 SGTC_1274 0865-0114 173 µM -0.748827475032403 0.209468515592692 no 2676 0.226980598752382 3772 870624 SGTC_119 0121-0043 24.815 µM -0.751029898575847 0.208795453787814 no 2677 0.226317331168489 3830 1092378 SGTC_1825 st052143 62.6 µM -0.752662691061909 0.20829729514938 no 2678 0.225826317481769 3760 674173 SGTC_820 1582-0060 59.9 µM -0.753277499363646 0.20810990139255 no 2679 0.225641588462131 3772 3848840 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.753487249597949 0.208045992228065 no 2680 0.225578585204888 3734 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2249 haloperidol 116.36 µM -0.75418765458847 0.207832668558999 no 2681 0.225368274763486 3753 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2029 5175081 200 µM -0.757168212095952 0.206926320155951 no 2682 0.224474545954415 3768 1380876 SGTC_1692 fluoroquinolonic acid 71 µM -0.757416568234319 0.206850904039486 no 2683 0.224400166530639 3795 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1960 st011366 51.8 µM -0.757839587896144 0.206722486855173 no 2684 0.22427350986935 3769 3972846 SGTC_1633 st005664 67.9 µM -0.758225652419833 0.206605329447742 no 2685 0.224157953408061 3792 2063822 SGTC_3349 9149703 23.001 µM -0.759911338329433 0.206094242203796 no 2686 0.223653791857141 3746 4910494 SGTC_547 1120-0019 610 nM -0.760090812185422 0.206039871277999 no 2687 0.223600152117892 3701 3676939 SGTC_742 0kpi-0133 140 µM -0.760219612905399 0.206000856830463 no 2688 0.223561661677981 3799 2728852 SGTC_522 1273-0010 11.6 µM -0.760297282480051 0.205977332406298 no 2689 0.22353845294524 3840 5705015 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.760482910857952 0.205921116064665 no 2690 0.223482990195282 3796 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2691 st077356 60.2 µM -0.760544400635966 0.205902496293998 no 2691 0.223464619772638 3826 2839272 SGTC_2923 7992654 58.14 µM -0.762690927940569 0.205253130773719 no 2692 0.222823871120929 3810 2985126 SGTC_2560 caryophyllene 100 µM -0.763009588624485 0.205156833653453 no 2693 0.222728838704721 3832 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1812 st052057 4.327 µM -0.766613540075195 0.204069613710738 no 2694 0.221655661341676 3793 3645418 SGTC_329 k048-0121 21.3 µM -0.766845133108302 0.2039998655856 no 2695 0.221586799225311 3770 6832902 SGTC_2387 9077560 195.08 µM -0.767755203169947 0.203725920329793 no 2696 0.221316316491405 3767 5303272 SGTC_842 0271-0008 11.1 µM -0.769649292140419 0.203156473775189 no 2697 0.220753978498256 3849 1221709 SGTC_508 roscovitine 141 µM -0.774837770813854 0.20160146255741 no 2698 0.219217763641278 3846 160355 A CDKinase inhibitor. SGTC_2715 st079500 56.4 µM -0.776884308771385 0.200990071793574 no 2699 0.218613514822881 3741 28246688 SGTC_2075 5212009 200 µM -0.778595814013226 0.200479625085871 no 2700 0.218108922845201 3679 780898 SGTC_3113 9123498 49.47 µM -0.779067982926383 0.200338940536256 no 2701 0.217969834586192 3837 8897275 SGTC_741 4582-0002 126 µM -0.779532014497947 0.200200738342143 no 2702 0.217833193208675 3759 2912688 SGTC_2417 cerulenin 830 nM -0.779893887546669 0.200093001721748 no 2703 0.217726668306843 3843 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_595 3909-8003 73.7 µM -0.780997244035893 0.199764726303509 no 2704 0.217402057816251 3883 699517 SGTC_1492 4158-0558 28.5 µM -0.78312345840386 0.199133040193762 no 2705 0.216777308432967 3812 3967268 SGTC_551 k048-0028 34.9 µM -0.783371497538057 0.199059427644316 no 2706 0.216704494327501 3771 6836383 SGTC_45 0kpi-0036 14.9 µM -0.7839168472319 0.198897637534855 no 2707 0.216544451796841 3793 2795021 SGTC_17 0960-0276 49.807 µM -0.785601383864703 0.1983983830526 no 2708 0.216050526741296 3797 6821114 SGTC_2375 9072683 200 µM -0.786127756340288 0.198242534621548 no 2709 0.215896322341815 3846 16798029 SGTC_1304 1165-0502 251 µM -0.786135245601506 0.198240317733431 no 2710 0.21589412877203 3825 767425 SGTC_2870 9038528 12.99 µM -0.786205478701335 0.198219528837649 no 2711 0.215873558452137 3824 6463316 SGTC_3301 9125354 19.7965 µM -0.787176785013293 0.197932158546026 no 2712 0.215589192531378 3783 41905162 SGTC_3290 9121031 71.43 µM -0.787405373973459 0.197864564907695 no 2713 0.215522300937914 3807 17014854 SGTC_324 1315-0088 19.6 µM -0.788734230428935 0.197471898974821 no 2714 0.215133678422223 3759 6787421 SGTC_2293 7624732 200 µM -0.788993049419959 0.197395474993141 no 2715 0.215058034470552 3741 894453 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.79024486039937 0.197026093219483 no 2716 0.214692390917318 3842 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_515 4092-1064 102 µM -0.790658648347491 0.196904085594778 no 2717 0.214571606399187 3824 717353 SGTC_2682 pyrogallin 40.03 µM -0.790834906747894 0.19685212874252 no 2718 0.214520168649345 3845 822798 An ATP competetive kinase inhibitor. SGTC_5 0352-0601 109.883 µM -0.791059429506727 0.196785956709981 no 2719 0.214454656223492 3732 762456 SGTC_3083 9117465 49.47 µM -0.79161195814291 0.1966231711573 no 2720 0.214293486074315 3778 16420915 SGTC_1317 1273-0028 910 nM -0.79402278640393 0.195913849838108 no 2721 0.21359108306393 3804 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2646 retinol 96.75 µM -0.79426914634388 0.195841452597191 no 2722 0.21351938088082 3798 445354 A vitamin A analog and teratogen. SGTC_2414 st077232 92.9 µM -0.79440368560296 0.195801922702995 no 2723 0.213480229631182 3801 729801 SGTC_3272 9137413 49.47 µM -0.794942134763176 0.195643765773127 no 2724 0.213323581509405 3774 17614870 SGTC_2721 ifenprodil 61.44 µM -0.795195248670498 0.195569446250269 no 2725 0.213249967601976 3808 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3256 9138902 49.47 µM -0.79567131949487 0.195429708377937 no 2726 0.213111550577827 3861 17228773 SGTC_458 nppb 133 µM -0.796115132874446 0.19529949345346 no 2727 0.212982559581263 3820 4549 A chloride channel blocker. SGTC_2625 euphol 100 µM -0.797136673996761 0.19499997348035 no 2728 0.212685829559982 3827 6708538 A triterpene alcohol. SGTC_1761 st044296 37 µM -0.797537891473883 0.194882411325437 no 2729 0.212569352806708 3828 1826700 SGTC_1351 1496-0003 46.5 µM -0.798886015853514 0.194487708460714 no 2730 0.212178254154811 3880 3891978 SGTC_1651 st011928 86.1 µM -0.798927481864989 0.194475575790653 no 2731 0.212166231298134 3832 720198 SGTC_1396 3511-0007 98.6 µM -0.800489209022586 0.19401896063622 no 2732 0.211713706596279 3835 X1396 SGTC_1162 k048-0130 20.1 µM -0.801117659766988 0.193835399738744 no 2733 0.211531766763099 3803 6797406 SGTC_126 0417-1624 672.48 µM -0.80157105009049 0.193703037081872 no 2734 0.211400564716966 3892 41912 YDL195W SEC31 SGTC_2575 plumbagin 510 nM -0.802013224457099 0.193574001904337 no 2735 0.211272654262188 3774 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2065 5221596 34.26 µM -0.802777632147386 0.193351056392143 no 2736 0.211051636400733 3835 788581 SGTC_2296 7971656 126.45 µM -0.807814556424469 0.191885918975717 no 2737 0.209598672079854 3907 666570 SGTC_1121 fusaric acid 630.51 nM -0.808362115250104 0.191727055995573 no 2738 0.209441077153581 3858 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2208 7283366 200 µM -0.809007987828699 0.191539772857326 no 2739 0.209255275831483 3823 898663 SGTC_1868 st057644 42.7 µM -0.809885572163024 0.19128548012081 no 2740 0.20900297239678 3851 688665 SGTC_1619 st003326 88.7 µM -0.810307244784538 0.191163368026586 no 2741 0.208881806263852 3789 2849032 SGTC_3015 9080845 49.47 µM -0.810580750183761 0.19108418921012 no 2742 0.208803237588147 3929 5296973 SGTC_710 3448-4187 58 µM -0.81073055227486 0.191040830575885 no 2743 0.208760211991722 3834 3946412 SGTC_450 aminopyrene 156 nM -0.812924150580091 0.190406607966747 no 2744 0.208130773517994 3769 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2766 oltipraz 83.91 µM -0.816070150049777 0.18949928315967 no 2745 0.207230007584059 3797 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1688 st021091 57.6 µM -0.81854513946695 0.188787354736724 no 2746 0.20652298904474 3874 3656366 SGTC_1915 st067105 30.6 µM -0.819198012081397 0.188599831639649 no 2747 0.206336724459358 3828 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1715 st032160 10.2275 µM -0.819687291391484 0.188459372379761 no 2748 0.206197198336207 3794 5289825 SGTC_2539 epi(13)torulosol 80 µM -0.819810468108646 0.188424021741868 no 2749 0.206162081263897 3889 6708597 SGTC_2433 5607874 27.82 µM -0.820380760525359 0.188260406125419 no 2750 0.205999539935975 3863 2252428 SGTC_664 1222-0054 14.9 µM -0.820857633104163 0.18812365976787 no 2751 0.205863682936864 3815 6813991 SGTC_2285 7945142 200 µM -0.820899096817988 0.188111772671947 no 2752 0.205851872784861 3910 2970608 SGTC_1054 3429-0080 167 µM -0.822368675742451 0.187690763344373 no 2753 0.205433550769 3874 1162877 SGTC_480 am 92016 50 µM -0.822428763930508 0.187673561497669 no 2754 0.20541645715534 3811 2129 K+ channel blocker. SGTC_1468 k284-1086 134 µM -0.823870937928363 0.187260992970262 no 2755 0.2050064475549 3868 15996457 SGTC_2143 5623677 140.463 µM -0.825788706518793 0.186713238631336 no 2756 0.204461980793274 3812 5375313 SGTC_3238 9133470 49.47 µM -0.825986859211634 0.186656698718329 no 2757 0.204405773076266 3854 3534688 SGTC_910 3454-3003 490 µM -0.826059200716523 0.186636059791397 no 2758 0.204385255077838 3787 820824 SGTC_1962 st076595 64.5 µM -0.826326726296542 0.186559747404467 no 2759 0.204309388272048 3884 279619 SGTC_1061 3448-9325 110 µM -0.826524910623109 0.186503227256336 no 2760 0.204253196564726 3784 723482 SGTC_523 1934-0222 13.7 µM -0.831373833833886 0.185123669336204 no 2761 0.202881238050562 3862 1361595 SGTC_2022 5136654 200 µM -0.831794232942341 0.185004361720382 no 2762 0.20276254983939 3924 1713771 SGTC_576 1073-0113 22.7 µM -0.831854532786471 0.184987252779886 no 2763 0.202745529227332 4029 5439563 SGTC_2415 st077333 57.7 µM -0.833620033617636 0.184486761137652 no 2764 0.202247566404288 3862 2766255 SGTC_1654 st012436 41.8 µM -0.833696576327383 0.184465081552855 no 2765 0.202225993949397 3823 4323132 SGTC_3052 9092717 49.47 µM -0.833831028257504 0.184427003878928 no 2766 0.202188103951639 3879 25237534 SGTC_1968 st069590 43.6 µM -0.83462555949417 0.184202087223444 no 2767 0.201964283239982 3886 6384066 SGTC_184 1494-0393 24.714 µM -0.835026842670009 0.184088556512839 no 2768 0.201851297521682 3867 3090647 SGTC_1881 5652484 16 µM -0.835222752867578 0.184033145586504 no 2769 0.20179615058875 3830 2255129 SGTC_937 3122-0005 46.7 µM -0.835360545057767 0.183994178885206 no 2770 0.201757368749397 3942 759535 SGTC_2427 5545055 42.75 µM -0.837625844371936 0.183354304166564 no 2771 0.201120436591801 3857 5372858 SGTC_2595 hexamethylquercetagetin 100 µM -0.838935904292247 0.182984888069422 no 2772 0.200752639211603 3864 386331 SGTC_123 0083-0120 66.675 µM -0.840427551003285 0.182564833259524 no 2773 0.200334353507595 3876 16001701 SGTC_1276 0871-0068 94.2 µM -0.840876782178698 0.18243844571085 no 2774 0.200208483328109 3894 3414906 SGTC_660 4031-1742 102 µM -0.842527050210005 0.181974625550931 no 2775 0.199746502509171 3816 6738706 SGTC_1605 st000082 49.1 µM -0.843083469743899 0.181818406051034 no 2776 0.199590881491596 3892 1114022 SGTC_3096 9117468 49.47 µM -0.843624185114015 0.181666676024385 no 2777 0.199439722584782 3833 41316311 SGTC_114 0364-0001 490.298 µM -0.843897941037367 0.181589887651564 no 2778 0.199363219426951 3952 4003655 SGTC_2069 5228469 200 µM -0.84838227361557 0.180334927928784 no 2779 0.198112555739181 3905 2835210 SGTC_2592 piperlongumine 83.33 µM -0.848499282747326 0.180302255441305 no 2780 0.198079985871048 3924 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1770 st043884 66.3 µM -0.848941742468704 0.180178740892735 no 2781 0.197956855016817 3892 670149 SGTC_279 1273-0055 2.93 µM -0.850722616192687 0.179682139533485 no 2782 0.19746172843902 3912 2847562 SGTC_1922 5578187 25 µM -0.851267786889392 0.179530289335424 no 2783 0.197310307444979 3901 1350412 SGTC_697 0508-1955 564 µM -0.851432648804571 0.179484385084484 no 2784 0.197264530933234 3884 6243113 SGTC_1683 st010134 710 nM -0.851439623523344 0.179482443202274 no 2785 0.197262594434188 3910 3818134 SGTC_1790 st045711 43.5 µM -0.853882243021243 0.178803188049241 no 2786 0.196585119623333 3885 585119 SGTC_1951 sophoraflavanone G 9.2 µM -0.855175011034827 0.17844434475752 no 2787 0.196227134007521 3891 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2699 st077704 54.6 µM -0.858111586766138 0.177630904618383 no 2788 0.195415424956286 3919 645852 SGTC_2966 9084041 48.03 µM -0.858317047132819 0.17757407920944 no 2789 0.195358709389934 3854 17741380 SGTC_1848 st056003 16.4 µM -0.858897602756675 0.177413573468088 no 2790 0.195198506061522 3936 146492 SGTC_3025 9087895 49.47 µM -0.860437092193244 0.176988395705057 no 2791 0.194774073311063 3933 17173641 SGTC_1363 1636-0063 10.4 µM -0.860654943688804 0.176928281300821 no 2792 0.194714057661191 3913 6072185 SGTC_2804 7954240 19.48 µM -0.860984398488244 0.176837395358823 no 2793 0.194623317924009 3961 828705 SGTC_2340 7987427 183.45 µM -0.862343067549462 0.176462894296594 no 2794 0.194249379881972 3944 2239331 SGTC_259 usnic acid 108.925 µM -0.862417688692499 0.176442340404818 no 2795 0.194228855051531 3990 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1261 0712-0010 12.7 µM -0.871078569514503 0.174067052495098 no 2796 0.191855627277243 3934 2840123 SGTC_681 1642-0006 26.6 µM -0.871569680324561 0.173932974798519 no 2797 0.19172158860143 3939 4446530 SGTC_3159 9100096 49.47 µM -0.872032762302585 0.173806609398789 no 2798 0.191595252367415 3902 25236875 SGTC_785 1270-0111 65.3 µM -0.873824372342658 0.173318266592659 no 2799 0.191106952718815 3880 6741994 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.874110015684253 0.173240489023229 no 2800 0.191029171802219 3927 7104 SGTC_2112 5488546 200 µM -0.874882048740348 0.173030384070003 no 2801 0.190819043738169 3899 600757 SGTC_3321 9137793 26.8275 µM -0.87639195900692 0.172619938923082 no 2802 0.190408494090774 3894 4904192 SGTC_3194 9111903 49.47 µM -0.876827346184164 0.172501701229478 no 2803 0.190290211698381 3962 17087251 SGTC_3307 9126885 69.2785 µM -0.878061918808596 0.172166710432888 no 2804 0.18995505873098 3923 24824909 SGTC_1888 azatryptophan 97.5 µM -0.878420495385173 0.172069491578243 no 2805 0.18985778296467 3989 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2517 totarol 10 µM -0.880389491506545 0.171536273382969 no 2806 0.18932417364093 3961 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2572 astragaloside iv 100 µM -0.881627529133729 0.171201545215518 no 2807 0.188989131505547 4025 45006101 An anti-inflammatory agent. SGTC_516 3992-2719 87.3 µM -0.883570516602677 0.170677062517697 no 2808 0.188464050307032 3889 5350887 YDR037W KRS1 SGTC_2662 daunorubicin 22.37 µM -0.88448040725296 0.17043180405627 no 2809 0.188218467208131 3830 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2911 7942208 15.64 µM -0.890232126889038 0.168886670784113 no 2810 0.186670628650754 3993 1243384 SGTC_129 0088-0017 176.636 µM -0.891493189085646 0.168549107576105 no 2811 0.186332321919319 3799 182446 SGTC_696 1560-0013 611 µM -0.895489481217708 0.167482241093766 no 2812 0.185262743132454 4019 1650269 SGTC_167 3672-0051 66.205 µM -0.89785604737325 0.166852508586647 no 2813 0.184631149815039 3893 3237971 SGTC_666 0272-0154 136 µM -0.900259932630989 0.166214411489815 no 2814 0.183990969197953 3978 6870312 SGTC_2212 7123476 200 µM -0.903230102666044 0.165428177365101 no 2815 0.183201892251035 3930 1085715 SGTC_2346 9031566 143.75 µM -0.903232692197409 0.165427492941336 no 2816 0.183201205219504 3945 4771086 SGTC_2320 7373003 200 µM -0.903692187082199 0.165306075560592 no 2817 0.183079321547113 4061 5415828 SGTC_143 4032-1194 15.74 µM -0.907189312639252 0.164383881843641 no 2818 0.182153347192126 3987 1806963 SGTC_3181 9108277 49.47 µM -0.907270922673536 0.164362401137799 no 2819 0.182131773374184 3905 17097298 SGTC_1703 st026983 48.3 µM -0.908111922403465 0.164141146282533 no 2820 0.181909546027688 3984 1104023 SGTC_2933 9026794 32.47 µM -0.908736959925391 0.163976833155516 no 2821 0.181744494838331 3959 17586027 SGTC_1404 3909-7820 48.3 µM -0.911552326752782 0.16323803830561 no 2822 0.181002214031099 3929 23741373 SGTC_165 k038-0023 64.381 µM -0.912284934188086 0.163046146212884 no 2823 0.180809371555271 3996 46368543 SGTC_1209 2323-2347 50.3 µM -0.913849518767893 0.162636825251353 no 2824 0.180397961181235 3984 5412760 SGTC_1193 1488-0126 41.5 µM -0.914555079084789 0.162452458005396 no 2825 0.180212625105132 3983 1384710 SGTC_2684 capsaicin 100 µM -0.91562377734446 0.162173459723309 no 2826 0.179932127907213 4018 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2061 5245884 80.95 µM -0.915678109973328 0.162159283787375 no 2827 0.179917874755033 3966 573863 SGTC_2784 7567673 72.73 µM -0.916324792286663 0.161990619746992 no 2828 0.179748284155637 3961 3471247 SGTC_2072 5231554 129 µM -0.916581562185252 0.161923682172848 no 2829 0.179680974843076 4039 789545 SGTC_1682 st012968 530 nM -0.917220737045897 0.161757133376677 no 2830 0.179513491204011 4006 24207270 SGTC_121 0557-0495 61.343 µM -0.918480579188897 0.161429185271105 no 2831 0.179183660913883 4107 3104427 SGTC_2675 theaflavin digallate 100 µM -0.919621899553498 0.161132464011832 no 2832 0.178885189263776 3943 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_459 nigericin 15.3 µM -0.921771814710211 0.160574494751779 no 2833 0.178323806060323 4056 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2924 9010168 62.78 µM -0.925223768321249 0.159681249628419 no 2834 0.177424761210231 4105 2993929 SGTC_2688 kanamycin b 96.69 µM -0.926104185478009 0.15945394979068 no 2835 0.177195919532684 4075 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_249 wiskostatin 11.211 µM -0.929286943175898 0.158634015847114 no 2836 0.17637019999055 3964 2775510 A n-wasp and actin depolymerizer. SGTC_2737 bleomycin 30.5 nM -0.929947695713792 0.158464141620691 no 2837 0.176199083136794 4032 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2997 9067075 71.4286 µM -0.931332403896502 0.158108531332904 no 2838 0.175840822519448 4024 27209819 SGTC_2031 5180455 200 µM -0.931719464703042 0.158009223048063 no 2839 0.175740762221238 3946 29949 SGTC_1305 1181-0477 144 µM -0.934264589691468 0.157357239856727 no 2840 0.175083712687426 4059 6252086 SGTC_336 4111-0029 111 µM -0.934485513590536 0.15730072944292 no 2841 0.175026752566387 4018 3131175 SGTC_2170 morpholine 200 µM -0.936681672491798 0.156739696688824 no 2842 0.174461163224004 4044 121171 Reacts with secondary amines. SGTC_2337 9009472 200 µM -0.938708493275488 0.156223093169529 no 2843 0.173940215791227 3966 5742383 SGTC_2467 5474540 200 µM -0.939276995638923 0.156078392874733 no 2844 0.173794273212401 3972 5413519 SGTC_3072 9116419 49.47 µM -0.94179947143427 0.155437415518558 no 2845 0.173147657924515 4060 17170162 SGTC_410 α-linolenic acid 100 µM -0.942182460630933 0.155340247584793 no 2846 0.173049616042222 4097 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1022 4477-0945 21.3 µM -0.943114099121079 0.155104049595263 no 2847 0.17281127241927 3971 4648966 SGTC_580 1123-0028 41 µM -0.943459051781183 0.155016654049262 no 2848 0.17272307533758 4077 1677248 YPR107C YTH1 SGTC_2056 5235370 200 µM -0.945083720740192 0.154605473068886 no 2849 0.172308067840259 3984 5511916 SGTC_325 2810-4341 181 µM -0.945373217105283 0.154532281320367 no 2850 0.172234185356151 4029 774970 SGTC_196 k015-0023 18.111 µM -0.946112644468152 0.154345440003089 no 2851 0.172045567570088 3959 5211998 SGTC_3273 9137859 49.47 µM -0.947636093740346 0.153960960146509 no 2852 0.171657372402523 4091 2377234 SGTC_1978 st071761 42 µM -0.948192496789297 0.15382069630064 no 2853 0.171515733107537 4053 5147680 SGTC_2326 6164455 177.58 µM -0.94927149709488 0.153548931843328 no 2854 0.171241273113421 4018 2888790 SGTC_1853 st056710 91.2 µM -0.951235844685026 0.153054994547493 no 2855 0.170742333094652 4101 269167 SGTC_584 0986-0246 15.4 µM -0.95234942159459 0.15277545273484 no 2856 0.170459900644326 4128 53315 YDR232W HEM1 SGTC_1159 4092-0538 61.2 µM -0.952468572871801 0.152745562192226 no 2857 0.170429698469359 4066 717301 SGTC_253 dyclonine 31.25 µM -0.952737077974063 0.152678218651702 no 2858 0.17036165101557 4127 3180 An oral anasthetic. SGTC_712 r015-0009 80.6 µM -0.954602658646523 0.152210857809253 no 2859 0.169889336088742 4067 6813872 YLR060W FRS1 SGTC_2197 6588183 93.1375 µM -0.955244002539153 0.152050409490638 no 2860 0.169727159144325 3996 884136 SGTC_978 1416-0512 87.4 µM -0.955929620164521 0.151879009256103 no 2861 0.16955389652695 4119 6814003 SGTC_1388 3346-4487 254 µM -0.960642349566809 0.150704330267917 no 2862 0.168366013673436 4103 3345614 SGTC_684 1140-0066 328 µM -0.96081383174119 0.150661701579585 no 2863 0.168322891317737 4115 6813534 SGTC_2229 7354935 190 µM -0.963290391417522 0.150046949982064 no 2864 0.167700906947707 3971 318112 SGTC_1338 1486-1223 76 µM -0.963432913272773 0.150011623022152 no 2865 0.167665157887236 4075 3444526 SGTC_3070 9117005 49.47 µM -0.965607664952532 0.149473254249098 no 2866 0.167120269202406 4117 8779016 SGTC_2136 5328288 199.296 µM -0.965950554837277 0.149388488280116 no 2867 0.167034461722438 4050 262395 SGTC_2393 9031399 185.94 µM -0.966118685578835 0.149346936328094 no 2868 0.166992397736937 4110 1526623 YDL150W RPC53 SGTC_570 0987-0065 62.6 µM -0.966281166531945 0.149306788000905 no 2869 0.166951753741904 3831 3104428 SGTC_3008 9078912 71.4286 µM -0.968307266635469 0.148806752800555 no 2870 0.16644546836408 4035 16648731 SGTC_2402 5553605 200 µM -0.973982445010773 0.147412100200167 no 2871 0.165032627860294 4155 6758546 SGTC_1096 rimcazole 32.2 µM -0.976825337791076 0.146716773782508 no 2872 0.16432781489362 3991 18528119 A dopamine reuptake inhibitor. SGTC_2920 7982904 15.77 µM -0.978468095172218 0.146315986239335 no 2873 0.163921431777821 4075 6456808 SGTC_1474 0330-0125 5.35 µM -0.978814225978267 0.14623163371534 no 2874 0.163835889651358 4068 X1474 SGTC_3260 9137109 49.47 µM -0.979578778975298 0.146045426926623 no 2875 0.163647042131538 3991 17478346 SGTC_1614 st002383 48.6 µM -0.981290170750571 0.145629195256006 no 2876 0.163224834249401 4068 1947235 SGTC_355 1311-2252 105 µM -0.982151912430986 0.14541991122091 no 2877 0.163012506957273 4055 5338538 SGTC_1806 st050005 60.3 µM -0.982272328753951 0.145390682827382 no 2878 0.162982851497823 4106 5194765 SGTC_1145 3546-0597 10.2 µM -0.984334847569846 0.144890665597765 no 2879 0.162475450441649 4043 875334 SGTC_3082 9117008 49.47 µM -0.988143087785139 0.143970478174423 no 2880 0.161541288063744 4135 41448529 SGTC_1350 1495-0454 146 µM -0.988588870581256 0.143863021677246 no 2881 0.16143216681461 4131 1069057 SGTC_1701 st028638 40.4 µM -0.988610096268822 0.143857906548656 no 2882 0.161426972269159 4083 3490878 SGTC_2620 irigenin 100 µM -0.991135387454508 0.143250218104086 no 2883 0.160809737720709 4135 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1948 st076329 66.6 µM -0.991289237904922 0.143213251500112 no 2884 0.160772183282279 3933 24208413 SGTC_2826 7992541 19.48 µM -0.992444829291796 0.142935796335933 no 2885 0.160490289913394 4093 2985066 SGTC_48 0382-0018 55 µM -0.99272944356829 0.142867516809855 no 2886 0.160420911088593 4116 762596 SGTC_2367 9070478 135.38 µM -0.993221939335544 0.14274941818883 no 2887 0.160300904461035 4044 572802 SGTC_1127 asiatic acid 681.4 nM -0.993275129775067 0.142736667272621 no 2888 0.160287947038235 4036 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_130 0136-0219 337.655 µM -0.995890246535597 0.142110715811461 no 2889 0.159651737400742 3924 234244 SGTC_1985 st071382 65.5 µM -0.997159937047512 0.141807475100502 no 2890 0.159343441883237 4067 6123237 SGTC_942 3253-1115 227 µM -1.00020944319891 0.141080951488018 no 2891 0.158604580116069 4155 46497897 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.00288358387256 0.140445936817206 no 2892 0.157958517051265 4066 15053 SGTC_3171 9103192 49.47 µM -1.00566786161683 0.139786833566521 no 2893 0.157287683941832 4134 13018434 SGTC_275 trichlorophene 5.69 µM -1.00774802788515 0.139295784281247 no 2894 0.156787720923475 4144 62616 SGTC_1104 tacrolimus 29.8 µM -1.00849982483098 0.139118602295602 no 2895 0.156607285885897 4137 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1149 3909-7961 23.3 µM -1.00917648482011 0.138959259656575 no 2896 0.156445001028375 4135 735261 SGTC_2955 9076254 12.21 µM -1.01027597905454 0.138700611372533 no 2897 0.156181543149636 4028 16459619 SGTC_2053 5265679 138 µM -1.01397735413945 0.137832300179367 no 2898 0.155296779134166 4030 764595 SGTC_2236 dapsone 200 µM -1.01415353477601 0.137791062368519 no 2899 0.155254748156208 4099 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1218 1348-1416 30.7 µM -1.01759937113292 0.136986203235741 no 2900 0.15443419316742 4058 6787668 SGTC_3213 9129884 49.47 µM -1.01795382839742 0.13690359369935 no 2901 0.154349949394828 4119 17190742 SGTC_2374 9071832 200 µM -1.02320635462233 0.135683434001901 no 2902 0.153105144508816 4018 17381698 SGTC_2314 7727897 200 µM -1.02495961803475 0.135277814923294 no 2903 0.152691121052903 4128 900724 SGTC_839 0122-0028 230 µM -1.02774323334323 0.13463553200627 no 2904 0.152035312640509 4109 759448 SGTC_888 0916-0002 6.97 µM -1.02869483033668 0.134416444231489 no 2905 0.151811549988872 4166 2802138 YIL048W NEO1 SGTC_1106 tegaserod maleate 11.7 µM -1.0297795010875 0.134167017334972 no 2906 0.151556762795099 4130 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_948 3448-0295 75.3 µM -1.03022685760948 0.134064237537487 no 2907 0.151451762405816 4112 678569 SGTC_874 0599-0792 117 µM -1.03144651504063 0.133784297071468 no 2908 0.151165738716291 4161 765305 SGTC_2477 5967686 25.23 µM -1.03180261487071 0.133702639508144 no 2909 0.15108229703512 4111 776118 SGTC_1705 st027868 56.3335 µM -1.03515696743252 0.132935131553567 no 2910 0.150297805867869 4072 292948 SGTC_979 1426-2828 121 µM -1.03618638149652 0.132700201250854 no 2911 0.150057599454162 4232 747872 SGTC_20 0481-0013 4.944 µM -1.04249658346808 0.131266352807726 no 2912 0.14859075432253 4160 182045 SGTC_796 1234-0020 70.7 µM -1.04287949845396 0.131179689822494 no 2913 0.148502052956698 4067 46495034 SGTC_3139 9095020 49.47 µM -1.04784581174834 0.130059271688498 no 2914 0.147354825877971 3831 25236292 SGTC_1820 st053765 18.6 µM -1.04785567504458 0.130057053103718 no 2915 0.147352553364913 4197 3690829 SGTC_1764 st044502 93.5 µM -1.05319072425524 0.128860859449946 no 2916 0.146126794416372 4191 8407 SGTC_3187 9109394 49.47 µM -1.05620002382247 0.128189508352792 no 2917 0.145438419950306 4154 17098090 SGTC_124 0136-0217 7.121 µM -1.05844719066713 0.127689769922656 no 2918 0.14492580734323 4199 3976905 SGTC_2081 5214970 32.255 µM -1.06017114188718 0.12730730642994 no 2919 0.144533373612828 4117 2063512 SGTC_2635 hydroquinidine 100 µM -1.06065875297077 0.127199273239921 no 2920 0.144422505683622 4081 442912 An experimental heart treatment. SGTC_2528 xanthyletin 44.79 µM -1.06123191598462 0.1270723670735 no 2921 0.144292259141108 4186 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2701 st077767 14.721 µM -1.06438627751867 0.126375524979136 no 2922 0.143576873811148 4121 5721188 SGTC_2793 7325131 81.82 µM -1.06531840212638 0.126170116385191 no 2923 0.143365934023988 4125 4176441 SGTC_2671 danthron 100 µM -1.06634537333743 0.12594407639778 no 2924 0.1431337728505 4144 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3124 9127567 49.47 µM -1.06643271250633 0.125924865776065 no 2925 0.143114040337059 4156 17592030 SGTC_3207 9114163 49.47 µM -1.06782770557103 0.125618308062188 no 2926 0.1427991190393 4198 849233 SGTC_1277 0873-0036 22 µM -1.06845001339431 0.125481720452501 no 2927 0.142658783534215 4239 5965735 SGTC_1036 k216-0215 33.5 µM -1.06874591454931 0.125416810780961 no 2928 0.142592088124831 4137 622330 SGTC_711 k292-0785 179 µM -1.06906761160477 0.125346269045748 no 2929 0.142519602307878 4093 4146315 SGTC_2727 riluzole 51.77 µM -1.06933594134928 0.125287450885636 no 2930 0.142459160450857 4182 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2775 cyproheptadine 69.59 µM -1.0698676578995 0.125170954993205 no 2931 0.142339441369386 4160 2913 A selective serotonin reuptake inhibitor. SGTC_1963 st076565 50.3 µM -1.07449630393286 0.124160041373127 no 2932 0.14130015022155 4188 4914280 SGTC_1799 st045822 46.1415 µM -1.07852219586843 0.123285427546885 no 2933 0.140400390946189 4148 3674992 SGTC_2164 5685496 200 µM -1.08046003727388 0.122865979562787 no 2934 0.139968686624985 4107 759046 SGTC_2835 9006588 71.43 µM -1.08078277054492 0.122796220900457 no 2935 0.139896877155521 4235 2345538 SGTC_1612 st002233 45.4 µM -1.08294413313638 0.122329759159639 no 2936 0.139416610555261 4181 1035021 SGTC_2802 7925815 54.55 µM -1.08423077642297 0.122052669195296 no 2937 0.139131244547153 4143 1262923 SGTC_1040 k898-0338 155 µM -1.08539846154649 0.121801579699555 no 2938 0.138872606744119 4188 20969351 SGTC_1620 st003704 16.5 µM -1.0917571731297 0.120440623463435 no 2939 0.137469923897495 4175 2834414 SGTC_1433 4060-0023 7.6 µM -1.09253729889716 0.120274393500223 no 2940 0.137298502673439 4198 3840627 SGTC_14 0354-0009 295 µM -1.09409594170947 0.119942760580289 no 2941 0.136956451074446 4265 1713507 SGTC_3065 9113888 49.47 µM -1.10001206185039 0.118689854362483 no 2942 0.135663433263449 4262 16648368 SGTC_1850 st056238 17 µM -1.10164069348453 0.118346574347468 no 2943 0.135308954802099 4213 5393177 SGTC_904 1141-0088 396 µM -1.10190073004544 0.118291829359937 no 2944 0.135252415593399 4192 1378119 SGTC_1249 0481-0015 10.2 µM -1.10323756325339 0.118010671109025 no 2945 0.134962006400153 4128 4227577 SGTC_953 1188-0045 9.7 µM -1.1042789414131 0.117791979748125 no 2946 0.134736077442018 4217 6144426 SGTC_304 1310-0298 97 µM -1.1077440874841 0.117066357876404 no 2947 0.133986176657616 4000 1550234 SGTC_1851 st056236 18.9 µM -1.10890460490397 0.116824048215103 no 2948 0.133735668549511 4204 5393171 SGTC_757 1066-0008 322 µM -1.11471868226849 0.115615453218653 no 2949 0.132485496298532 4249 6842497 SGTC_444 curcumin 90.4 µM -1.11680294299391 0.115184360192556 no 2950 0.132039295121972 4143 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_900 1112-0045 141 µM -1.11758713982137 0.115022458977696 no 2951 0.13187168188958 4083 56211 YIL048W NEO1 SGTC_3253 9135987 49.47 µM -1.12206302085977 0.114101489358258 no 2952 0.130917822695775 4218 4182430 SGTC_1219 1469-0211 33.1 µM -1.12313826495016 0.113881028827874 no 2953 0.130689388461659 4246 6822282 SGTC_657 3534-0529 86.7 µM -1.12407354609012 0.113689512306835 no 2954 0.130490913385874 4264 1049549 SGTC_1052 3253-3998 198 µM -1.12569719407778 0.113357585093259 no 2955 0.130146855922233 4151 5450317 SGTC_609 0986-0026 86.3 µM -1.13105669198136 0.112266835042301 no 2956 0.129015615412261 4182 2848610 SGTC_2276 7947513 42.08 µM -1.1316494707905 0.11214665659329 no 2957 0.128890916403984 4175 2105100 SGTC_2529 gangaleoidin 93.61 µM -1.13174255679857 0.11212779293279 no 2958 0.128871342105246 4243 4565183 SGTC_3106 9121286 49.47 µM -1.13186948711602 0.112102074457741 no 2959 0.128844654285137 4205 15943471 SGTC_1411 3909-8223 150 µM -1.13247514381455 0.111979415058672 no 2960 0.128717364314573 4254 X1411 SGTC_1884 5633444 25 µM -1.13352645267576 0.111766728767028 no 2961 0.128496619515974 4210 5724239 SGTC_301 4119-0100 24.5 µM -1.13639121898802 0.111188635658775 no 2962 0.127896434573469 4252 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2349 9023730 187.07 µM -1.13907339027402 0.110649332645835 no 2963 0.127336272542228 4255 4126287 SGTC_43 0570-0105 72.5 µM -1.14859291021487 0.108750387249552 no 2964 0.125361940934825 4233 1114046 YDL195W SEC31 SGTC_1290 0986-0249 10.2 µM -1.15153484484669 0.108168300750604 no 2965 0.124756134328352 4095 53329 SGTC_385 1494-0393 12.4 µM -1.15221306243825 0.108034428397028 no 2966 0.124616765642417 4212 3090647 SGTC_3318 9139014 38.6185 µM -1.15360303519686 0.107760436622957 no 2967 0.124331476718012 4244 16643984 SGTC_76 0433-0009 400.328 µM -1.15386275737131 0.107709295677418 no 2968 0.124278219988648 4310 2841569 SGTC_3104 9120930 49.47 µM -1.15450804453294 0.107582310230137 no 2969 0.124145971197212 4263 17014836 SGTC_1010 4112-3296 15.2 µM -1.15665059099373 0.107161454372934 no 2970 0.123707571920116 4307 704384 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.15718393226687 0.107056876075459 no 2971 0.123598610464416 4210 6708514 SGTC_1737 st035557 69.7 µM -1.16196026267912 0.106123606645286 no 2972 0.122625803272473 4104 5716916 SGTC_2912 7964298 10.93 µM -1.16465739449851 0.1055992052593 no 2973 0.122078850720275 4259 2975850 SGTC_642 0335-0876 158 µM -1.16565213129132 0.105406273054373 no 2974 0.12187756068227 4292 6812350 SGTC_1180 1193-0155 285 µM -1.16615407628252 0.105309016155154 no 2975 0.12177607812022 4329 2921347 SGTC_2021 4019055 173 µM -1.16651823263569 0.105238497839977 no 2976 0.121702490649734 4096 44827708 YER133W GLC7 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.16833293337394 0.104887593200438 no 2977 0.121336247988972 4270 5377381 SGTC_2576 guaiol 23.12 µM -1.17210248447886 0.10416139258843 no 2978 0.120577956284957 4175 227829 SGTC_2627 acetyl isogambogic acid 100 µM -1.1721417892786 0.104153839803432 no 2979 0.12057006725677 4275 6857789 A caspase activator and apoptosis inducer. SGTC_1070 indatraline 8.81 µM -1.17282009458877 0.104023559633108 no 2980 0.120433979058673 4301 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_363 0455-0021 3.06 µM -1.17469944363543 0.103663215738042 no 2981 0.120057491023113 4236 4597466 SGTC_907 3448-6986 75.5 µM -1.17833593756132 0.102968532660706 no 2982 0.119331353059266 4298 590582 SGTC_151 3013-0144 2.285 µM -1.17917477823363 0.102808769220077 no 2983 0.119164293537301 4097 906558 YHR107C CDC12 SGTC_870 0573-2213 57.6 µM -1.18044570947671 0.102567054238616 no 2984 0.118911495585437 4254 3916321 SGTC_3001 9076041 71.4286 µM -1.18139997539635 0.102385836720531 no 2985 0.118721933902299 4251 16004211 SGTC_2880 9042983 58.44 µM -1.18301215095301 0.102080209642391 no 2986 0.118402165898351 4237 6464714 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.18537542344699 0.101633394393692 no 2987 0.117934522196517 4327 804 An inhibitor of viral and cellular DNA polymerases. SGTC_901 1112-0062 60.1 µM -1.18660191975288 0.101402067343066 no 2988 0.11769233916243 4280 1908457 SGTC_1672 st016598 6.51 µM -1.18922486525276 0.100908646425116 no 2989 0.117175596151987 4260 4665860 YNL267W PIK1 SGTC_959 1222-0044 107 µM -1.18986209056264 0.10078903817768 no 2990 0.117050300278461 4269 6083612 SGTC_1739 st037196 92.5 µM -1.19055641014996 0.100658830970957 no 2991 0.116913886221046 4325 612214 SGTC_2512 diallyl trisulfide 49.23 µM -1.1911092959904 0.100555234913314 no 2992 0.116805340489451 4305 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1402 3909-7673 35.9 µM -1.19247451996295 0.100299761564512 no 2993 0.116537617908119 4300 5328014 SGTC_1945 st075991 56.6 µM -1.19256827288903 0.100282235047586 no 2994 0.116519248793474 4265 1084980 SGTC_776 4476-4378 112 µM -1.1941988615842 0.0999777642439535 no 2995 0.116200094158078 4334 2892008 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.19680057543916 0.0994933593807004 no 2996 0.115692146970249 4314 688788 SGTC_1032 k061-1018 98.7 µM -1.19803295661725 0.099264505876418 no 2997 0.115452093538104 4352 4005393 SGTC_1910 st062352 60.4 µM -1.19994370130393 0.098910441474355 no 2998 0.115080603012689 4188 2245730 SGTC_786 4544-0069 423 µM -1.20104262028848 0.0987072288002445 no 2999 0.114867334539679 4273 748821 YLR208W SEC13 SGTC_1839 st053978 48 µM -1.20214229670867 0.0985041821103909 no 3000 0.114654200657507 4292 3788398 SGTC_777 1315-0167 517 µM -1.20347942639203 0.0982577037131246 no 3001 0.114395424072336 4312 4221767 SGTC_35 0133-0054 64.071 µM -1.20537299555896 0.0979094279050673 no 3002 0.114029670773013 4277 99677 SGTC_246 cycloheximide 667 µM -1.20578781352494 0.0978332532274986 no 3003 0.113949657766574 4183 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2292 7671323 168.05 µM -1.20963792374065 0.0971283139786275 no 3004 0.113208929669211 4341 937504 SGTC_2091 4-phenylthiadiazole 200 µM -1.20990762793688 0.0970790723349974 no 3005 0.113157169952736 4316 270010 SGTC_2284 7945075 39.21 µM -1.21008847178681 0.0970460647645613 no 3006 0.113122473141814 4271 1245402 SGTC_1049 3226-0134 66 µM -1.21198456907938 0.0967004854529911 no 3007 0.112759143761753 4324 5702385 SGTC_1352 1496-0991 99 µM -1.21314649323163 0.0964891623458073 no 3008 0.112536908497103 4288 3000039 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.21770844459119 0.0956627457855218 no 3009 0.111667393435961 4278 689007 SGTC_562 3772-2733 112 µM -1.21882338165629 0.095461564552275 no 3010 0.111455617499391 4291 2876874 YIL048W NEO1 SGTC_763 3453-1109 128 µM -1.21910311300924 0.0954111382300146 no 3011 0.111402529258156 4327 1560353 SGTC_3350 9150499 3.57 µM -1.22143952632979 0.0949907257126467 no 3012 0.110959824629724 4309 4910996 YPR165W RHO1 SGTC_333 3486-0131 40.1 µM -1.23205072805794 0.0930985185817683 no 3013 0.108965067622668 4348 6744690 SGTC_3212 9128307 49.47 µM -1.23355648187612 0.0928322830347593 no 3014 0.108684108811435 4230 27243542 SGTC_1348 1493-0373 93.8 µM -1.23609175965301 0.0923852877670518 no 3015 0.108212228776769 4338 3010129 SGTC_2888 9058547 12.99 µM -1.23645050916895 0.0923221654274669 no 3016 0.108145575598695 4217 16476514 SGTC_2155 5570423 76 µM -1.24075296085175 0.0915676299612945 no 3017 0.107348511542038 4280 797402 SGTC_828 2074-0507 139 µM -1.24237964323272 0.0912835468769066 no 3018 0.10704826139344 4393 X828 SGTC_61 0978-8327 98.565 µM -1.24267419993637 0.0912321755766911 no 3019 0.106993957473214 4221 6150059 YHR072W ERG7 SGTC_2749 bexarotene 57.39 µM -1.24340772188506 0.0911043409903087 no 3020 0.10685881310731 4344 82146 An retinoic acid receptor inhibitor. SGTC_3131 9127911 49.47 µM -1.24356993625784 0.0910760890157127 no 3021 0.106828943305933 4360 45595681 SGTC_2434 5670830 169.91 µM -1.24666933454827 0.0905375315853797 no 3022 0.106259383663222 4348 1549830 SGTC_296 1222-0039 74.9 µM -1.24760355687885 0.0903756639366684 no 3023 0.106088137635501 4333 5984176 SGTC_751 0833-0568 350 µM -1.2483396182399 0.0902482820035374 no 3024 0.105953355667101 4344 6954252 SGTC_2881 9058953 51.95 µM -1.25204781161479 0.0896085739884647 no 3025 0.105276221316613 4277 17122249 SGTC_1046 2001-0062 216 µM -1.25489093548651 0.089120389066162 no 3026 0.104759177508866 4258 739778 SGTC_1604 st002052 72.4 µM -1.25626355162123 0.0888854106254109 no 3027 0.104510216027785 4410 6254834 YHR062C RPP1 SGTC_1336 1486-0901 104 µM -1.25645153550483 0.088853265570382 no 3028 0.104476153408899 4334 5006114 SGTC_2161 5662504 8.5105 µM -1.25887706254418 0.0884392789272883 no 3029 0.104037369972389 4299 2859334 SGTC_2327 6189656 200 µM -1.26132406521175 0.0880230848835758 no 3030 0.103596057114828 4414 5349088 SGTC_791 1348-1292 225 µM -1.26721613587275 0.0870269371134374 no 3031 0.102539008837216 4308 5437054 SGTC_1125 tnp00248 1.32998 µM -1.26923786429543 0.086687079473886 no 3032 0.102178120069617 4377 24207736 SGTC_3303 9125618 40.5795 µM -1.27075269158172 0.0864330839461976 no 3033 0.10190832188061 4359 22695467 SGTC_3243 9134147 49.47 µM -1.27458050213539 0.085793743826884 no 3034 0.101228881171292 4438 24282180 SGTC_1062 mesoridazine 14.2 µM -1.27676951993639 0.0854297176660486 no 3035 0.100841814693827 4382 4078 A neuroleptic. SGTC_2907 7721985 69.9 µM -1.27809823148224 0.0852093224264136 no 3036 0.100607396224416 4349 3267881 SGTC_1723 st034307 2.5525 µM -1.27980852968784 0.0849262603502944 no 3037 0.100306241642846 4356 867466 SGTC_3251 9135047 49.47 µM -1.28421317878417 0.0842005171165111 no 3038 0.0995336876138924 4387 17682963 SGTC_1676 st018489 23.4 µM -1.28448669995847 0.0841556036908728 no 3039 0.0994858571324157 4364 3696235 SGTC_2740 felodipine 17.08 µM -1.2866063929876 0.0838081499446549 no 3040 0.0991157571518044 4402 3333 L-type calcium channel blocker SGTC_2043 5101342 149 µM -1.28714671668085 0.0837197542762745 no 3041 0.0990215774919655 4376 678451 SGTC_306 1672-3436 11.6 µM -1.28944636438959 0.0833443206744092 no 3042 0.0986214757602524 4376 6797378 SGTC_1490 4089-0339 670 nM -1.29572090220148 0.0823263970175104 no 3043 0.0975358287094462 4332 742542 SGTC_3279 9140807 49.47 µM -1.29927620849808 0.0817537872290241 no 3044 0.0969245780778233 4413 45595718 SGTC_2441 5730946 39.09 µM -1.29928600355914 0.0817522138156649 no 3045 0.0969228979429767 4424 1774275 SGTC_425 3825-7017 13.1 µM -1.29947640843751 0.0817216329787092 no 3046 0.0968902422745568 4396 3397440 SGTC_175 3793-3120 23.7 µM -1.30848696451722 0.0802842917953988 no 3047 0.0953540965476561 4369 5322297 SGTC_3322 9139058 2.11 µM -1.31057409464326 0.0799540996463684 no 3048 0.0950008480571152 4417 4908926 YPR165W RHO1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.31079842901231 0.0799186702789711 no 3049 0.0949629367318292 4372 115019 SGTC_3112 9123419 49.47 µM -1.31224700221735 0.0796901813388449 no 3050 0.0947184038056104 4428 17015854 SGTC_2994 9053520 71.4286 µM -1.31312782164443 0.0795514881632717 no 3051 0.0945699401758519 4408 4647384 SGTC_188 3229-0966 278.469 µM -1.31774382520429 0.0788276408755677 no 3052 0.0937947092205169 4418 5722370 SGTC_2139 5578692 56.4705 µM -1.31859629732842 0.0786945101430266 no 3053 0.0936520561155769 4357 650991 YMR113W FOL3 SGTC_84 0443-0269 128.823 µM -1.31902120746737 0.0786282155101281 no 3054 0.0935810112974952 4300 6150058 SGTC_166 k072-0058 166.424 µM -1.31989016549227 0.0784927721703704 no 3055 0.0934358457704523 4269 5846229 SGTC_2012 4023501 200 µM -1.32129274555823 0.078274527112999 no 3056 0.0932018859588368 4377 3477460 SGTC_2138 5575593 77.673 µM -1.32165254965348 0.0782186149104353 no 3057 0.0931419380382485 4391 762213 SGTC_1108 betulinic acid 729.144 nM -1.32380468987125 0.0778848127010288 no 3058 0.0927839590878843 4370 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2186 6124449 200 µM -1.32466625750405 0.07775148487941 no 3059 0.0926409346866135 4389 3834182 YLR033W RSC58 SGTC_3178 9107506 49.47 µM -1.32496376988211 0.0777054850230999 no 3060 0.0925915840882656 4383 8897194 SGTC_1339 1486-1321 22.7 µM -1.32745106595439 0.0773217199177213 no 3061 0.0921797584344617 4408 3469382 SGTC_1591 genipin 88.4 µM -1.32972462291349 0.0769721936633446 no 3062 0.091804509501174 4413 442424 A DNA cross-linking agent. SGTC_634 1611-4317 11.2 µM -1.32990639406416 0.0769443009276248 no 3063 0.0917745572254273 4412 2843522 SGTC_1859 st055998 20 µM -1.33187685443147 0.0766424271853348 no 3064 0.0914503289513787 4334 676301 SGTC_2664 lyso-paf C-16 73.48 µM -1.33386278676587 0.0763390953486858 no 3065 0.0911244146760083 4344 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_445 e6 berbamine 66 µM -1.3382866667884 0.0756666757307489 no 3066 0.0904015032596091 4398 6610268 A calcium/calmodulin antagonist. SGTC_1027 k015-0025 8.67 µM -1.34242692103006 0.0750414629960058 no 3067 0.0897288053589895 4366 3598955 SGTC_611 3453-1652 23.7 µM -1.343425688046 0.0748912323840345 no 3068 0.0895670868047803 4410 1560575 SGTC_1423 4048-0112 5.59 µM -1.34601182648549 0.0745033018216871 no 3069 0.0891493512801483 4460 X1423 SGTC_415 dibenzyl ketone 100 µM -1.34692643779722 0.0743664744496192 no 3070 0.0890019629047488 4387 7593 SGTC_830 4076-0286 57.8 µM -1.34748684967222 0.0742827307522009 no 3071 0.0889117429517099 4457 6866659 SGTC_2008 4012253 172 µM -1.35083495019647 0.073783915649351 no 3072 0.0883741548056252 4389 603940 SGTC_2439 5492030 7.2 µM -1.3511897756415 0.0737312025524484 no 3073 0.0883173244715861 4407 5722370 SGTC_1296 1068-0102 11.9 µM -1.35155839536502 0.0736764706608332 no 3074 0.0882583136369429 4401 767053 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.35416110341481 0.0732909094407126 no 3075 0.0878424927156381 4412 3256 An antibiotic and ribosome inhibitor. SGTC_2345 9052315 157.45 µM -1.35518356387968 0.0731398666823 no 3076 0.0876795399855314 4420 6469265 SGTC_1355 1499-0035 1.68 µM -1.35546250122621 0.073098702102634 no 3077 0.0876351240461357 4400 1548538 SGTC_1975 st070967 30.8 µM -1.35892243128187 0.0725895707286125 no 3078 0.0870855849915541 4392 261391 SGTC_2175 5807670 165.306 µM -1.36011395238468 0.0724148676194156 no 3079 0.0868969332519827 4356 241186 SGTC_1450 4112-4260 37.6 µM -1.36131328157353 0.0722393451680322 no 3080 0.086707353760953 4409 1633175 SGTC_1947 st076332 61.6 µM -1.36677132388403 0.0714446736581789 no 3081 0.0858484968889331 4288 24208416 SGTC_685 1278-0033 54.9 µM -1.3712922951577 0.0707915307846637 no 3082 0.0851419282881513 4487 3590572 SGTC_1933 st074711 15.9 µM -1.37202582646151 0.0706859917606142 no 3083 0.0850276990293597 4405 17250958 SGTC_1623 st003709 20.3 µM -1.37259509190757 0.0706041703431783 no 3084 0.0849391292844996 4386 16192618 SGTC_1063 disulfiram 1.84 µM -1.37491643366017 0.070271273708743 no 3085 0.084578676903223 4434 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1303 1160-0052 261 µM -1.37509087031473 0.0702463071163291 no 3086 0.0845516372179699 4362 3562476 SGTC_1729 st035615 45.989 µM -1.37590051774663 0.0701305140274009 no 3087 0.0844262174603377 4430 17385451 SGTC_726 3448-4391 34.2 µM -1.37811665026382 0.0698143210346927 no 3088 0.0840836378134856 4513 1356692 SGTC_2549 cedrol 20.94 µM -1.37881703429105 0.0697146202678768 no 3089 0.0839755866487477 4353 6708665 A sedative which affects the nervous system. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.38149911110688 0.0693338356768879 no 3090 0.0835627754717486 4450 16486 A toxic proline analog. SGTC_469 w7 172 µM -1.38203104974898 0.0692585050757067 no 3091 0.0834810837838759 4523 45115570 A P450 inhibitor. SGTC_3012 9080433 71.4286 µM -1.38215574213044 0.0692408558642226 no 3092 0.0834619430228611 4415 17688859 SGTC_514 4466-0038 2.65 nM -1.38382431611945 0.0690050158206573 no 3093 0.0832061277728814 4215 5722064 SGTC_2773 thioridazine 9.09 µM -1.38597071103158 0.0687025505273459 no 3094 0.0828779235615631 4406 5452 An antipsychotic. SGTC_1891 st059073 26.2 µM -1.38837317922046 0.0683652136829558 no 3095 0.0825117195501598 4495 688754 SGTC_98 0074-0023 107.663 µM -1.38931935559292 0.0682327099143543 no 3096 0.0823678303563251 4428 3563821 SGTC_588 3970-1144 52.9 µM -1.38936055939594 0.0682269441870804 no 3097 0.082361568609032 4316 1888707 SGTC_2667 digitoxin 100 µM -1.39472855510627 0.0674790009012184 no 3098 0.0815488552726558 4381 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2095 5432005 200 µM -1.39567207874009 0.067348193412814 no 3099 0.0814066330257229 4434 783734 SGTC_1148 3909-7663 27.7 µM -1.3967597423458 0.0671976460650583 no 3100 0.0812429160346697 4472 4084526 SGTC_307 1501-1223 22.3 µM -1.39676639198841 0.0671967264655353 no 3101 0.0812419158836132 4458 2830329 SGTC_2983 9022671 12.99 µM -1.39693003951035 0.0671740982127784 no 3102 0.0812173051208657 4421 6405161 SGTC_2731 amoxapine 43.43 µM -1.39733958700665 0.0671174941275842 no 3103 0.0811557383979056 4588 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2972 9093619 59.92 µM -1.39828826799857 0.0669865173906524 no 3104 0.0810132597420701 4381 25236256 SGTC_2481 5478948 45.16 µM -1.40162715152876 0.0665271165714434 no 3105 0.0805133073511168 4436 77792 SGTC_1836 st055642 81 µM -1.40170786914774 0.0665160408107085 no 3106 0.0805012499045596 4433 8571 SGTC_1020 4335-0961 93.3 µM -1.40233783628777 0.0664296481842857 no 3107 0.0804071934575326 4396 669075 SGTC_3157 9099274 49.47 µM -1.40300248917113 0.0663385930235149 no 3108 0.0803080483394196 4462 17217662 SGTC_386 1509-0011 3.07 µM -1.40576429800684 0.0659612695478267 no 3109 0.0798970634135886 4450 3107280 SGTC_1023 4482-3888 16 µM -1.41105720788549 0.0652427922933418 no 3110 0.0791138731687268 4446 3303168 SGTC_1245 0418-0076 17.2 µM -1.41621824414329 0.0645480773659451 no 3111 0.0783558079457421 4455 6790114 SGTC_1796 st049173 110.4 µM -1.4170361357423 0.0644385123495287 no 3112 0.0782361813719802 4431 94134 SGTC_2063 5246145 200 µM -1.41732217430373 0.0644002286561304 no 3113 0.0781943774683512 4485 711240 SGTC_1156 4092-0367 4.88 µM -1.41754899080579 0.064369883868822 no 3114 0.0781612407831386 4491 1357585 SGTC_1196 1588-0294 184 µM -1.41968007852286 0.0640853173126556 no 3115 0.0778504201967555 4480 6144269 SGTC_1205 4161-2785 76 µM -1.42011605008534 0.0640272222260897 no 3116 0.0777869491886812 4459 3498106 SGTC_2148 5546263 113.568 µM -1.42336496000327 0.0635955797367452 no 3117 0.0773151923439651 4466 792097 SGTC_1510 1123-0200 71.5 µM -1.43320924865444 0.0623015080715464 no 3118 0.0758990236891829 4451 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_278 4092-0821 23.9 µM -1.43565714098763 0.0619829327762636 no 3119 0.0755499632460239 4459 877900 SGTC_2511 berberine 10.47 µM -1.43846878031227 0.061618588636239 no 3120 0.075150544712635 4446 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2725 haloperidol 53.21 µM -1.43896000845588 0.0615551051710042 no 3121 0.075080926890894 4424 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1216 1165-0504 9.65 µM -1.44194384087314 0.0611705888354624 no 3122 0.0746591085324174 4484 6304004 SGTC_728 3030-5151 22.5 µM -1.44282356167354 0.0610575812286832 no 3123 0.0745350900364325 4534 3125388 SGTC_2131 toluylene red 5.2905 µM -1.44309627699628 0.061022581784308 no 3124 0.0744966759862431 4413 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_928 2764-0428 58.7 µM -1.44363711699476 0.0609532184365243 no 3125 0.0744205392219936 4482 662578 SGTC_1621 st003705 32.4 µM -1.44416176109782 0.0608859911435023 no 3126 0.0743467392156185 4459 24207032 SGTC_853 0419-0306 21 µM -1.44428217318809 0.0608705698592686 no 3127 0.0743298091196006 4469 762713 SGTC_309 k408-0051 1.48 µM -1.44613506744661 0.0606336529174115 no 3128 0.0740696608323423 4388 3640463 SGTC_2890 9046729 58.44 µM -1.45636644497958 0.0593384005224807 no 3129 0.0726456731829582 4439 903329 SGTC_1373 2887-0003 58.5 µM -1.45828984106758 0.0590973463522837 no 3130 0.0723803346004842 4427 776948 SGTC_833 3852-0053 558 µM -1.45899351206512 0.0590093492694617 no 3131 0.0722834467011094 4535 3123681 SGTC_2358 9037157 4 µM -1.45998391675358 0.0588856691008608 no 3132 0.0721472470959057 4475 2388925 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.46399062766881 0.058387392232391 no 3133 0.0715982545857824 4471 5282362 SGTC_371 0195-0006 7.36 µM -1.46512316630359 0.0582471510210317 no 3134 0.0714436586190983 4323 3928593 SGTC_247 mechlorethamine 29.705 µM -1.46780207012592 0.057916478082576 no 3135 0.0710789975027933 4434 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1302 1159-0335 255 µM -1.4742579500204 0.0571256532276223 no 3136 0.0702060761626322 4492 649284 SGTC_1113 artemisinin 1.17947 µM -1.47507795191307 0.0570258169023878 no 3137 0.0700957936505216 4516 2240 An anti-malaria and mitochondrial poison. SGTC_1785 bathophenanthroline 24 µM -1.4764016938069 0.0568649394855283 no 3138 0.0699180441402257 4405 72812 An iron chelator. SGTC_1455 4262-0120 131 µM -1.47880223672405 0.0565741079581546 no 3139 0.0695965889446888 4526 1529587 SGTC_1310 1188-0297 994 nM -1.47908781644701 0.0565395874376308 no 3140 0.0695584230043049 4355 1588352 SGTC_2695 st077686 51.995 µM -1.48200925822658 0.0561873998597929 no 3141 0.0691689157699719 4460 2876092 SGTC_502 l-744,832 89.3 µM -1.48249934070617 0.0561284889032492 no 3142 0.0691037394457684 4502 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1780 st038448 24.544 µM -1.48473003052327 0.0558609613075929 no 3143 0.0688076766440521 4502 728868 YDL195W SEC31 SGTC_113 0099-0221 2.5 µM -1.48863822079484 0.0553946766721322 no 3144 0.068291330639641 4456 89219 SGTC_358 0075-0058 9.45 µM -1.49135904358555 0.0550718748937702 no 3145 0.0679336274757563 4452 1069125 SGTC_219 mitoxanthrone 164.414 µM -1.49745479238861 0.0543540627574994 no 3146 0.0671374801529786 4439 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2413 inermin 26.06 µM -1.4978128282077 0.0543121330477788 no 3147 0.0670909434648599 4516 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_628 1636-0253 16 µM -1.50154048201594 0.0538771047482542 no 3148 0.0666079121604939 4488 4456143 SGTC_2177 5811945 192 µM -1.50715312467719 0.0532273023311719 no 3149 0.065885706156352 4509 5343475 SGTC_2490 carminic acid 95.39 µM -1.50821636619187 0.0531049086020515 no 3150 0.0657495799511969 4487 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2201 6605497 169.863 µM -1.51250285402673 0.0526137366657889 no 3151 0.0652029935677456 4458 670741 SGTC_652 0437-0092 114 µM -1.51408047576238 0.0524338733870366 no 3152 0.0650027149410576 4463 3091274 SGTC_1896 st058441 89 µM -1.51445228997749 0.0523915543311071 no 3153 0.0649555828342084 4515 688759 SGTC_2728 chlorpromazine 9.18 µM -1.51466116289253 0.0523677927849433 no 3154 0.0649291172167704 4594 2726 A thorazine and dopamine antagonist. SGTC_1775 st081588 35.1725 µM -1.51523631522718 0.0523024072229071 no 3155 0.0648562847681146 4487 1426443 YGL099W LSG1 SGTC_3325 9138760 55.175 µM -1.519327249082 0.0518392024232045 no 3156 0.0643400720520786 4447 43844959 SGTC_2831 7999036 19.48 µM -1.52075950681615 0.0516778046138633 no 3157 0.0641600997509082 4474 2988270 SGTC_1791 st048313 56.1 µM -1.52167876699519 0.0515744259604832 no 3158 0.064044795202479 4515 1204976 SGTC_753 1322-0200 289 µM -1.52387462450875 0.051328148528154 no 3159 0.0637700167308852 4554 5403907 SGTC_1457 k015-0032 57.3 µM -1.52572168477516 0.0511217158187496 no 3160 0.0635395958489853 4494 4302660 SGTC_223 busulfan 5 mM -1.52884801049491 0.050773814829323 no 3161 0.0631510635868746 4503 2478 A DNA alkylator. SGTC_370 0180-0345 38.7 µM -1.5295087976655 0.0507005236030482 no 3162 0.0630691798824051 4347 3989527 SGTC_840 0245-0196 390 µM -1.53029967919008 0.0506129137544811 no 3163 0.0629712838335614 4567 3827528 SGTC_1803 st050068 52.4 µM -1.53410681301978 0.0501928648529097 no 3164 0.0625016887512699 4534 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3180 9109287 49.47 µM -1.53438230025 0.0501625779191401 no 3165 0.0624678146899895 4537 18891271 SGTC_567 1080-0542 68.4 µM -1.54080283059754 0.0494608255966419 no 3166 0.061682390168536 4406 5950415 SGTC_1380 2291-0730 164 µM -1.5409661381984 0.0494430790922046 no 3167 0.0616625137403674 4521 2999191 SGTC_2981 9013952 38.96 µM -1.54269840886375 0.0492551473918798 no 3168 0.0614519840669894 4461 2996344 SGTC_686 1319-0111 510 µM -1.54365414684748 0.0491517050966666 no 3169 0.0613360700356748 4527 4562600 SGTC_917 harmaline 728.087 nM -1.54618422394458 0.0488787049891394 no 3170 0.0610300412261207 4441 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1774 st048371 48.465 µM -1.54648000740282 0.0488468686532413 no 3171 0.0609943424076387 4513 4242727 SGTC_577 r071-0003 38.6 µM -1.54703922143675 0.0487867235306976 no 3172 0.0609268941251005 4487 4568517 YMR134W ERG29 SGTC_1158 4092-0494 91.8 µM -1.54761909422273 0.0487244190204298 no 3173 0.0608570157333919 4595 1148199 SGTC_313 3474-0040 5.03 µM -1.54822030035871 0.0486598895137796 no 3174 0.0607846327194903 4541 1043375 YIL048W NEO1 SGTC_1744 st037937 38.9 µM -1.54825716667235 0.0486559347506533 no 3175 0.060780196342264 4545 1016152 SGTC_1371 2421-0008 32.7 µM -1.5494694140795 0.0485260363066931 no 3176 0.0606344592758079 4515 2827552 SGTC_2089 5281248 129.67 µM -1.55258313770263 0.0481936556922446 no 3177 0.0602613783423671 4504 2737878 SGTC_1627 st003713 25.6 µM -1.55283113793728 0.0481672609242529 no 3178 0.0602317408132193 4515 16195070 YER133W GLC7 SGTC_1550 gossypolone 36.6 µM -1.56232600444839 0.0471653876016484 no 3179 0.0591056044729668 4555 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2235 salicylic acid 500 µM -1.56254074271238 0.0471429236469745 no 3180 0.0590803277898248 4594 338 A COX inhibitor and kinase inhibitor. SGTC_947 3447-0010 211 µM -1.56381166908135 0.0470101464938795 no 3181 0.0589309015373644 4478 748350 SGTC_2809 7964133 12.99 µM -1.56732268258332 0.0466448993014813 no 3182 0.0585196430487652 4507 1253665 SGTC_2520 obtusaquinone 4.71 µM -1.56789654512076 0.0465854180430956 no 3183 0.0584526391088809 4553 5967872 SGTC_3145 9085516 49.47 µM -1.57245810309635 0.0461147714795814 no 3184 0.0579221741895929 4524 25236195 SGTC_2603 homopterocarpin 100 µM -1.5731324230161 0.0460455225138 no 3185 0.0578440793733237 4521 101795 A weak amylase inhibitor. SGTC_394 menadione 8.33 µM -1.57365918806418 0.0459914847625654 no 3186 0.057783130892938 4541 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1018 4259-0013 28.1 µM -1.58072959366586 0.0452710931219372 no 3187 0.0569699394015235 4571 6801262 SGTC_793 0488-0545 106 µM -1.58302938650717 0.045038737362213 no 3188 0.0567073833034449 4560 292548 SGTC_3193 9111931 49.47 µM -1.58788327476993 0.0445514834754498 no 3189 0.0561563680836257 4529 17087244 SGTC_981 1488-1094 54.9 µM -1.59100596053389 0.0442402660362579 no 3190 0.0558041171775804 4510 3449522 SGTC_783 0848-0141 92.7 µM -1.59408329286502 0.0439352854102374 no 3191 0.0554586902050597 4477 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.59544837725789 0.0438005420274845 no 3192 0.0553060025927957 4531 2333 A French combination drug. SGTC_1118 chelidonine 707.474 nM -1.59588978857841 0.0437570430368086 no 3193 0.0552567008856281 4539 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2101 5377231 179.231 µM -1.59734605851028 0.043613781658234 no 3194 0.0550942946520425 4566 2844213 SGTC_1958 st076513 41.9 µM -1.60407363426075 0.0429568588373143 no 3195 0.0543489113770304 4476 732122 YGL099W LSG1 SGTC_2032 5185112 25.99 µM -1.60624082252988 0.0427469516022892 no 3196 0.0541105035445012 4435 5718189 SGTC_2962 9082311 13.18 µM -1.60826622686134 0.0425515273995696 no 3197 0.0538884420333918 4521 16459453 SGTC_674 0498-0004 451 µM -1.61061098653501 0.0423261926861423 no 3198 0.0536322688514336 4546 4231473 SGTC_997 3996-0078 137 µM -1.61294247328172 0.0421030916631048 no 3199 0.053378503215745 4595 735687 SGTC_887 0885-0007 9.62 µM -1.6137781405335 0.0420233583616148 no 3200 0.053287778820874 4562 5719458 SGTC_208 k072-0098 12.366 µM -1.61953336303777 0.0414775508522847 no 3201 0.0526662770458422 4558 5948901 SGTC_1420 4'-methoxyflavone 42 µM -1.62132852925724 0.0413084829866004 no 3202 0.0524735998250898 4561 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2362 9071156 126 µM -1.62192998837194 0.0412519629535312 no 3203 0.0524091698275029 4543 653133 SGTC_100 0086-0128 49.5915 µM -1.62311289934692 0.0411409858978891 no 3204 0.0522826363077154 4549 93297 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.62569972755421 0.0408991411323647 no 3205 0.0520067740259875 4498 6708739 YPR165W RHO1 SGTC_3263 9137018 49.47 µM -1.63599604599684 0.0399479365692799 no 3206 0.0509202074640103 4512 43844957 SGTC_2884 9058502 51.95 µM -1.63776125394346 0.0397866811936148 no 3207 0.0507357535568321 4540 6471554 SGTC_3192 9110362 49.47 µM -1.63949778325878 0.0396285624249617 no 3208 0.0505548159817382 4547 16649480 SGTC_1772 st048439 82.2 µM -1.64048043527344 0.0395393142015078 no 3209 0.0504526565703955 4597 2927068 YDL195W SEC31 SGTC_2006 4011487 200 µM -1.64839326431854 0.038826584485102 no 3210 0.0496359986645153 4519 45595294 SGTC_1721 st082152 9.2685 µM -1.65308290412107 0.0384091381084313 no 3211 0.0491569960798104 4506 5296051 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.65556045855277 0.0381900809475312 no 3212 0.0489054316762081 4541 16623 A steroid. SGTC_1710 st031758 61.5 µM -1.66233778262328 0.037596053807726 no 3213 0.048222533100129 4602 5394341 SGTC_1367 1812-0510 76.9 µM -1.66671358279103 0.0372165418426774 no 3214 0.0477856853734644 4613 1142582 YDR527W RBA50 SGTC_1800 st050079 29.0735 µM -1.67539370227711 0.0364729805261897 no 3215 0.0469285057185851 4403 3645560 SGTC_1789 tunicamycin 25 nM -1.67593514250279 0.0364270050688025 no 3216 0.0468754486269505 4500 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2455 5377712 9.75 µM -1.6835001780224 0.0357895797680499 no 3217 0.0461391524717856 4580 2243908 SGTC_328 k915-0120 63.5 µM -1.68490514765816 0.0356722101647662 no 3218 0.0460034366324708 4593 6624543 SGTC_608 k048-0125 159 µM -1.68555862228448 0.03561772720854 no 3219 0.0459404223156671 4632 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2406 ethylparaben 405.7 µM -1.68579723132851 0.035597850366508 no 3220 0.0459174306256225 4524 8434 A possible steroid mimic. SGTC_2867 9039098 71.43 µM -1.68855974662427 0.0353683860037639 no 3221 0.0456519151015992 4566 6463460 SGTC_2172 5754775 163.918 µM -1.69494491225889 0.0348426514865171 no 3222 0.0450429357466713 4570 2263357 SGTC_1120 ficusin 1.78878 µM -1.69562088865686 0.0347873712367114 no 3223 0.044978849639261 4580 6199 A DNA cross-linker. SGTC_1462 k081-0014 26.5 µM -1.69774647422442 0.0346140133764497 no 3224 0.0447778110918876 4015 3270634 SGTC_503 tyrphostin 8 294 µM -1.70164226670365 0.0342981237536542 no 3225 0.0444112245650332 4596 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2331 7980721 200 µM -1.70398060108561 0.0341096608554563 no 3226 0.0441923557215554 4550 2981221 SGTC_3281 9140613 49.47 µM -1.70847046523313 0.0337501779927685 no 3227 0.0437745410307832 4584 16013766 SGTC_1697 st025554 27.742 µM -1.71228993647939 0.0334468296152192 no 3228 0.0434216251620894 4618 1269519 SGTC_368 fentichlor 4.58 µM -1.7193974895674 0.0328883124666719 no 3229 0.04277100952543 4596 7329 A pesticide. SGTC_983 1491-0821 12.2 µM -1.72695126532876 0.0323031804350942 no 3230 0.0420882081540749 4605 46495113 SGTC_359 0081-0058 15.9 µM -1.72869824666743 0.0321690857669477 no 3231 0.0419315576627737 4584 3494159 SGTC_2062 5245942 200 µM -1.73129429840635 0.0319706672595195 no 3232 0.04169964392495 4633 1376160 SGTC_2225 6654152 15.4 µM -1.73671812083266 0.0315593805772079 no 3233 0.0412184688189209 4552 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2732 terfenadine 20 µM -1.74062736564086 0.0312656637227302 no 3234 0.0408744587966178 4673 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2241 6772625 37.8075 µM -1.74276846299027 0.0311057552482331 no 3235 0.0406870336027914 4413 2285411 SGTC_3258 9138477 49.47 µM -1.74720841950563 0.0307763117346395 no 3236 0.0403005958977139 4640 4970355 SGTC_2952 9073731 13.78 µM -1.75075167957032 0.0305154799795959 no 3237 0.0399943466083011 4585 16457353 SGTC_2584 androsterone 48.74 µM -1.75284799618982 0.0303620267890204 no 3238 0.0398140510305812 4503 2754130 A steroid. SGTC_1988 st071872 53.4 µM -1.75963526968514 0.029869569818316 no 3239 0.0392348337222029 4650 16414116 SGTC_190 3970-0790 3.722 µM -1.76158309979482 0.0297294729435568 no 3240 0.0390698807006091 4579 2832352 SGTC_1092 toremifene 6.32 µM -1.76338423971891 0.0296004122880813 no 3241 0.0389178530459204 4614 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1574 spiramycin 23.7 µM -1.7672222710014 0.0293269489900981 no 3242 0.0385955056603222 4588 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2764 methyldopa 94.69 µM -1.76989089070275 0.0291380465288163 no 3243 0.0383726593014645 4575 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3111 9122088 49.47 µM -1.77990750433113 0.0284380004606483 no 3244 0.0375455496864778 4577 16876704 SGTC_3195 9113082 49.47 µM -1.78042862162258 0.0284019666457903 no 3245 0.03750292057154 4590 17018038 SGTC_565 1418-0001 44.5 µM -1.78967462805849 0.0277689224188382 no 3246 0.0367531167479714 4648 2862145 SGTC_3053 9095903 49.47 µM -1.79099992502459 0.0276791543598653 no 3247 0.0366466535160924 4711 17174018 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.79555020859152 0.0273727828118764 no 3248 0.036283040384113 4637 75037 A free radical scavenger. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.79876416239107 0.0271580951017506 no 3249 0.0360279972655567 4594 6728940 SGTC_154 3389-1638 511.116 µM -1.80400584966017 0.0268109725273479 no 3250 0.035615194963724 4618 5238686 SGTC_2310 7668677 200 µM -1.81234382011862 0.0262664412697148 no 3251 0.0349665438223901 4585 2197143 SGTC_2360 9040895 200 µM -1.81862537175858 0.0258623426375278 no 3252 0.0344843021478328 4643 4914414 SGTC_1712 st032288 53.4 µM -1.83685974741739 0.0247186700265198 no 3253 0.033115301463966 4428 2883011 SGTC_467 ro 31-8220 72.8 µM -1.84414218331936 0.0242739195999157 no 3254 0.0325812108424391 4626 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2506 ethyl hematommate 54.16 µM -1.84675931693786 0.024115737093568 no 3255 0.0323910152689528 4638 3940691 An allergen. SGTC_738 1315-0003 72.4 µM -1.85852634706236 0.0234151842616744 no 3256 0.0315471527321311 4636 6251474 SGTC_3295 9122362 53.5725 µM -1.86634991855371 0.0229589472372088 no 3257 0.0309962125145681 4629 4730473 SGTC_3056 9094900 49.47 µM -1.86854283405189 0.0228324175801789 no 3258 0.0308432227231884 4629 25236784 SGTC_435 c-PAF 6.7 µM -1.87116114787299 0.022682112804227 no 3259 0.0306613740717425 4564 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_148 3253-0744 288.01 µM -1.87507935457329 0.0224587457970534 no 3260 0.0303909036657654 4546 6893655 SGTC_2958 9077254 16.72 µM -1.87888703074716 0.0222434599591232 no 3261 0.0301299600396407 4653 16457351 SGTC_1959 st077091 55.8 µM -1.88300540290926 0.0220125701517372 no 3262 0.0298498178811936 4634 821356 YKL052C ASK1 SGTC_3110 9122132 49.47 µM -1.88972051993045 0.0216404381429787 no 3263 0.029397674114061 4659 918317 SGTC_3188 9110789 49.47 µM -1.90945693979654 0.0205773394141824 no 3264 0.0281015857433466 4629 849217 SGTC_261 5-fluorouridine 15.376 µM -1.91581547422188 0.020244402303284 no 3265 0.0276942936882726 4667 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_856 0433-0016 11.3 µM -1.94532180886878 0.0187585863686434 no 3266 0.0258681294506637 4696 3911780 SGTC_2324 6149169 200 µM -1.95189425700383 0.0184405694087436 no 3267 0.0254753801354668 4651 2888231 SGTC_2334 9017922 200 µM -1.95210186816174 0.0184305991299418 no 3268 0.0254630557463922 4666 3163164 SGTC_3317 9138495 8.753 µM -1.95312416552153 0.0183815714542763 no 3269 0.0254024420743041 4616 17020139 SGTC_419 nsc-638432 893 µM -1.95574617370744 0.0182563319158212 no 3270 0.0252475312468276 4659 368090 SGTC_1631 benzylvanillin 81.9 µM -1.96117358758219 0.0179994016714316 no 3271 0.024929388418275 4677 75506 SGTC_2932 9016711 44.54 µM -1.96211842185603 0.0179549903748178 no 3272 0.0248743493321672 4642 7117328 SGTC_2714 st079313 56.9 µM -1.96243474099482 0.0179401429009348 no 3273 0.0248559456930259 4682 2939799 SGTC_2896 9052656 71.43 µM -1.97250436181249 0.0174729341649411 no 3274 0.024276029436059 4340 6469436 SGTC_3250 9135583 49.47 µM -1.98119107585144 0.017078274493956 no 3275 0.0237849248195518 4682 7699353 SGTC_390 dec-rvkr-cmk 16.7 µM -1.99700356354083 0.0163794129879925 no 3276 0.0229123979403411 4709 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1886 st057356 49.9 µM -1.99878275744892 0.0163023328792838 no 3277 0.0228159320959954 4678 24207747 SGTC_1698 5-fluorocytosine 1.055 µM -1.99886934060053 0.016298589773399 no 3278 0.0228112464025296 4686 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_468 gf-109203x 121 µM -1.99905983149627 0.0162903571873849 no 3279 0.0228009403003417 4740 2396 A protein kinase C inhibitor. SGTC_2581 avocatin a 64 µM -2.01523509223538 0.0156041690388207 no 3280 0.0219400111137784 4612 6710728 A skin care supplement. SGTC_1075 aripiprazole 15.2 µM -2.01960795964413 0.0154229778220198 no 3281 0.0217120344352286 4735 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.02141184828205 0.0153487610332481 no 3282 0.02161857460537 4668 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -2.02921312240642 0.0150313165360273 no 3283 0.0212182937858498 4690 616764 SGTC_375 3970-0961 9.27 µM -2.03224365516981 0.0149095306473149 no 3284 0.0210644977195163 4679 2898222 SGTC_1497 4476-2978 41.3 µM -2.03751110678666 0.0146998695774227 no 3285 0.0207994250321453 4725 1528379 SGTC_2636 apigenin dimethyl ether 100 µM -2.03867421821782 0.0146539174888921 no 3286 0.0207412762604572 4644 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1840 st055363 71 µM -2.04071417434678 0.0145736215519757 no 3287 0.0206396228196761 4698 676033 SGTC_446 go6976 132 µM -2.04346656591758 0.0144658832980103 no 3288 0.0205031369074186 4695 3501 A protein kinase C inhibitor. SGTC_2130 NSC 7 2.4545 µM -2.05232698689154 0.0141236990597445 no 3289 0.0200689474974573 4700 21448 SGTC_951 1171-0579 82.7 µM -2.05609691800779 0.0139802352696542 no 3290 0.0198865876334833 4633 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2570 licareol 100 µM -2.05758813904927 0.013923834931 no 3291 0.019814843095447 4659 443158 SGTC_1288 0973-0013 65.5 µM -2.06045923062944 0.013815798002061 no 3292 0.019677329761017 4714 4315430 SGTC_1666 st014829 29 µM -2.07228052724326 0.0133785544065336 no 3293 0.019119643666675 4718 3858230 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.07913173405062 0.0131306541108089 no 3294 0.0188026220194842 4714 5393153 SGTC_583 1488-1091 88.9 µM -2.08445460520527 0.0129408040048294 no 3295 0.018559417646861 4746 4303273 SGTC_1613 st002381 52.1 µM -2.08844618864718 0.0127999984408643 no 3296 0.0183788023482588 4718 551167 SGTC_3062 9077494 49.47 µM -2.11101297473013 0.0120286140072041 no 3297 0.0173855983287107 4654 16459633 SGTC_3128 9127691 49.47 µM -2.11235558995481 0.0119840185594167 no 3298 0.0173279805531485 4703 41316314 SGTC_2185 6113692 200 µM -2.11758100786856 0.0118118166623802 no 3299 0.0171052840164822 4700 874150 SGTC_146 3448-8650 53.125 µM -2.13303928836532 0.0113149061089074 no 3300 0.0164607516998703 4676 2891488 YIL048W NEO1 SGTC_198 3454-2873 16.191 µM -2.13957680734654 0.011110284432671 no 3301 0.0161944912971952 4728 710957 SGTC_1730 st033808 45.1 µM -2.15483101043919 0.0106453070477903 no 3302 0.0155875303115956 4657 1045166 SGTC_1908 st060353 56.5 µM -2.16847043430282 0.0102439973526416 no 3303 0.0150614558818155 4709 4227716 SGTC_3311 9131146 2.8755 µM -2.18192408468115 0.00986114395324506 no 3304 0.0145575679927439 4697 4900406 YPR165W RHO1 SGTC_3328 9140624 29.0385 µM -2.21338263349039 0.00901433408877983 no 3305 0.0134356384657289 4716 4904392 SGTC_2540 epiandrosterone 100 µM -2.23670190295529 0.00842840226635659 no 3306 0.0126529147775066 4736 441302 A steroid. SGTC_606 k015-0008 38.6 µM -2.26896039747009 0.00767306911774363 no 3307 0.0116353671387444 4756 1970475 SGTC_2938 9059746 27.26 µM -2.27976823125963 0.00743368096112286 no 3308 0.0113107190605479 4707 6471769 SGTC_2211 7117706 200 µM -2.29222903600051 0.00716586860528589 no 3309 0.0109462151406675 4727 822771 SGTC_1835 st008666 49.2 µM -2.30294850974405 0.00694232917605759 no 3310 0.0106408701632677 4718 690455 SGTC_2707 st078556 66.6 µM -2.32303031394504 0.00654007093425879 no 3311 0.0100887620039938 4703 17250899 SGTC_1650 st011916 45.8 µM -2.34139334680399 0.00619042902221747 no 3312 0.00960595709157908 4742 242528 SGTC_176 1486-1328 72.834 µM -2.34593745413827 0.00610650445613331 no 3313 0.00948964603101029 4740 22310231 SGTC_575 k072-0246 11.9 µM -2.34760414288488 0.00607597621518455 no 3314 0.0094472951362449 4784 6796779 SGTC_1370 2001-0092 44.6 µM -2.34800612158422 0.00606863356561632 no 3315 0.00943710555116345 4695 790957 SGTC_3240 9133527 49.47 µM -2.35447629222183 0.00595152490317578 no 3316 0.00927441344101274 4751 17617455 SGTC_1902 st060212 70.5 µM -2.36227091076347 0.00581310828402383 no 3317 0.00908168178517584 4740 688944 SGTC_863 0466-0191 129 µM -2.37173628461412 0.00564886788067667 no 3318 0.00885236114626431 4774 765160 YPR165W RHO1 SGTC_141 0443-0274 32.331 µM -2.38397866074484 0.00544255916167651 no 3319 0.00856329772451783 4703 1627241 SGTC_1570 verbenone 133 µM -2.39800388648254 0.005214458989833 no 3320 0.00824234516701544 4746 29025 A natural terpanoid with antifungal properties. SGTC_797 k781-0471 270 µM -2.4122847740662 0.00499097965650291 no 3321 0.00792644700489941 4741 23738129 SGTC_1709 st033179 39.1045 µM -2.41763792486091 0.0049094330059887 no 3322 0.00781080622322182 4757 573381 SGTC_920 mycophenolic acid 780.421 nM -2.51791398772484 0.00358618646348321 no 3323 0.00590260728457371 4744 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_276 colchicine 750 µM -2.53057413074251 0.00344421555033272 no 3324 0.00569380092820271 4780 2833 A microtubule depolymerizer. SGTC_1901 st060216 58.6 µM -2.56139283609721 0.00311949345727853 no 3325 0.00521266994457407 4763 688792 SGTC_187 1488-2104 32.728 µM -2.57228246472575 0.00301151834115256 no 3326 0.00505152126225182 4772 2852859 SGTC_58 0957-0393 9 µM -2.60143391212749 0.00273884589299744 no 3327 0.00464174750738256 4352 6997992 SGTC_2663 amphotericin b 100 µM -2.60236344624708 0.00273053019820088 no 3328 0.00462918386873794 4781 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1502 4534-4282 27.7 µM -2.60674587436092 0.00269163081729292 no 3329 0.00457035858138254 4781 3278949 SGTC_2742 clothiapine 36.27 µM -2.62827563672782 0.00250769951273649 no 3330 0.00429094732083475 4778 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1473 k844-0725 134 µM -2.63944760851147 0.00241680458970926 no 3331 0.00415206288075007 4788 54682906 SGTC_2730 imipramine 71.33 µM -2.64378439477107 0.00238233135522166 no 3332 0.00409924300993371 4757 3696 A tricyclic antidepressant. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.69778687018151 0.00198881329853548 no 3333 0.0034901057087099 4785 688664 SGTC_2505 galangin 7.89 µM -2.74906630827238 0.00167075837164361 no 3334 0.00298826472767002 4771 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3058 9093861 49.47 µM -2.75638530643286 0.00162935017597912 no 3335 0.00292220527089989 4775 17217477 SGTC_1892 st058411 7.36 µM -2.76817862349683 0.00156459128788364 no 3336 0.00281852753848198 4771 3934738 SGTC_1916 st067606 49.2 µM -2.80786264850445 0.00136353674484751 no 3337 0.00249357462799921 4729 19590279 SGTC_1001 4048-4355 44.4 µM -2.82494974853921 0.00128447453433228 no 3338 0.00236440158390859 4775 21824233 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.83574664588957 0.00123670224016607 no 3339 0.00228593489808205 4770 6710655 SGTC_1002 4049-0206 172 µM -2.85303046059055 0.00116360188976996 no 3340 0.00216522352185243 4783 4662749 SGTC_1003 4049-0218 100 µM -2.86255787058628 0.00112501951588805 no 3341 0.00210118255327384 4779 295161 SGTC_462 ag-879 158 µM -2.93111048368924 0.000880168364145988 yes 3342 0.00168876317941111 4787 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3057 9095946 49.47 µM -2.97769109591962 0.000742862690404243 yes 3343 0.00145214266177046 4803 24540043 SGTC_495 decylubiquinone 155 µM -3.02876468284168 0.000615180805634849 yes 3344 0.00122777934699309 4789 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1045 1348-1485 165 µM -3.05381771426503 0.000560257536546751 yes 3345 0.00112974663399522 4780 6810614 SGTC_140 0062-0056 502.533 µM -3.32825435409352 0.000192548481088438 yes 3346 0.000436960185670016 4765 3758964 SGTC_999 SEC7.066 22.7 µM -3.36270921147852 0.000167434463642756 yes 3347 0.000385908088748243 4800 740511 YDR170C SEC7 SGTC_2499 avocadenofuran 51.48 µM -3.38798455539592 0.000150997619719371 yes 3348 0.00035204114438878 4797 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_369 0957-0393 4.5 µM -3.54359811920804 7.87318289232379e-05 yes 3349 0.000197353203483671 4797 6997992 SGTC_2335 9018011 154.17 µM -3.67488271520669 4.45428371843398e-05 yes 3350 0.000118979350531751 4804 6458208 SGTC_138 0850-0259 40.9225 µM -3.71438481734374 3.73913977936365e-05 yes 3351 0.000101849311522628 4785 6813004 SGTC_559 1550-0661 158 µM -3.75934622678521 3.05755038619285e-05 yes 3352 8.51789737683703e-05 4807 5830875 SGTC_2836 9010338 19.48 µM -4.11955005921291 5.636168716308e-06 yes 3353 1.89806474077222e-05 4790 2994051