SGTCid condition conc unit MES1|YGR264C.score MES1|YGR264C.strain.pval MES1|YGR264C.strain.significant MES1|YGR264C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1820 st053765 18.6 µM 6.81619330813726 7.2953716762097e-12 yes 1 4.67422437504579e-12 2 3690829 SGTC_3257 9139206 32.98 µM 5.66593799396396 9.65398290341315e-09 yes 2 7.31111996830314e-09 1 4910041 SGTC_1013 4112-3890 241 µM 5.30210107552624 7.22431385557636e-08 yes 3 5.72387127250354e-08 2 705171 SGTC_2731 amoxapine 43.43 µM 4.82229891841927 8.48563215058176e-07 yes 4 7.09565314576808e-07 1 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2406 ethylparaben 405.7 µM 4.63354832596797 2.10791157963074e-06 yes 5 1.79725400215149e-06 7 8434 A possible steroid mimic. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 4.10251930762698 2.28097264816785e-05 yes 6 2.04337869847777e-05 8 6708739 YPR165W RHO1 SGTC_693 4161-2696 114 µM 4.0327329913429 3.05895895787436e-05 yes 7 2.75659546699122e-05 3 805759 SGTC_2629 bisabolol 100 µM 3.85823542589319 6.24735189714313e-05 yes 8 5.71043051193636e-05 9 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1814 st052110 31.539 µM 3.84767647954646 6.51732614854945e-05 yes 9 5.96216878708418e-05 9 674163 SGTC_521 r062-0005 13.8 µM 3.65976955662377 0.000136012114974779 yes 10 0.000126221083378537 3 2832033 SGTC_2317 5986382 200 µM 3.59078064468057 0.000176742797227531 yes 11 0.000164844511054217 7 877883 SGTC_2259 7964009 200 µM 3.53180200014112 0.000220340437774275 yes 12 0.000206369135507022 7 313134 SGTC_1680 diphenhydramine 100 µM 3.51054581493046 0.000238376965015275 yes 13 0.000223593869981524 19 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2415 st077333 57.7 µM 3.41633723427365 0.00033615936020426 yes 14 0.000317347967213456 21 2766255 SGTC_1180 1193-0155 285 µM 3.41601157107744 0.000336554291285474 yes 15 0.000317727733764671 5 2921347 SGTC_3293 9120939 62.045 µM 3.3412633892937 0.00043952437449575 yes 16 0.000416990330909649 16 934087 SGTC_2337 9009472 200 µM 3.24865820111112 0.000607486021607616 yes 17 0.000579753561002938 16 5742383 SGTC_506 n9-isopropylolomoucine 153 µM 3.20948703646686 0.000694974400814208 yes 18 0.000664860213229704 6 6610355 SGTC_1130 3454-2858 15.9 µM 3.14290618813739 0.000870762914583849 yes 19 0.000836397211798563 21 715628 YIL048W NEO1 SGTC_1170 0310-0127 64.8 µM 3.08021107665183 0.0010728016622824 no 20 0.00103426970549142 25 774975 SGTC_2179 6298986 200 µM 3.06595820355737 0.0011243586534625 no 21 0.00108486821503059 11 738374 SGTC_2289 7946404 165.07 µM 3.04280351351945 0.00121297578040946 no 22 0.00117192659613048 31 1246120 YPR165W RHO1 SGTC_501 nsc-95397 161 µM 2.97861064084815 0.00149311471751015 no 23 0.00144779234200639 14 262093 SGTC_1241 0364-0022 50.8 µM 2.92944706529662 0.00174628226305557 no 24 0.0016978282218874 15 4563895 SGTC_2794 7785382 27.27 µM 2.91880296440893 0.00180599588284189 no 25 0.00175689122179147 32 2205081 SGTC_3208 9114115 49.47 µM 2.90630728825845 0.00187846308263003 no 26 0.00182861048840836 35 650895 SGTC_1893 st059353 36.1 µM 2.90547392403525 0.00188338883030275 no 27 0.00183348701091183 14 3112488 SGTC_1809 st050081 57.6 µM 2.90475379523191 0.00188765473158477 no 28 0.00183771044451975 11 5036894 SGTC_2376 9072922 81.32 µM 2.89433824332824 0.00195034422293491 no 29 0.00189979310517099 13 17087968 SGTC_153 4077-0274 519.67 µM 2.8930627654371 0.00195814969843725 no 30 0.00190752525443623 22 3121976 SGTC_25 0118-0223 35.662 µM 2.88142486614298 0.00203069092754692 no 31 0.00197940802984985 10 5333628 SGTC_2569 tetrandrine 100 µM 2.87316144514275 0.00208367007058421 no 32 0.00203193192279631 17 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3294 9122953 26.2835 µM 2.85766178702428 0.00218643695899455 no 33 0.00213387504411186 19 16459826 SGTC_2625 euphol 100 µM 2.83862554361157 0.00231892847003581 no 34 0.00226541460716175 23 6708538 A triterpene alcohol. SGTC_2310 7668677 200 µM 2.83163825602197 0.00236935547003119 no 35 0.00231551040141189 29 2197143 SGTC_2564 betulinic acid 100 µM 2.82021660939382 0.00245392569460552 no 36 0.00239956210866127 21 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3020 9089140 49.47 µM 2.81376174876423 0.00250291859259536 no 37 0.00244827521907062 24 17217859 SGTC_2567 aureobasidin a 60 nM 2.8092543881059 0.00253765242228618 no 38 0.00248281962219067 77 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2273 7815444 169.05 µM 2.80674668415619 0.00255716494001697 no 39 0.00250222892772427 21 2824616 SGTC_117 lucigenin 22.078 µM 2.75918602034193 0.00295384145347105 no 40 0.0028972770040551 16 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_254 nsc-64875 3.808 µM 2.75755846894778 0.00296834785088364 no 41 0.00291173988494223 14 56993 SGTC_3315 9136395 68.55 µM 2.7455929014976 0.00307698335816854 no 42 0.00302008316621344 22 16876844 SGTC_573 3702-0553 84.7 µM 2.72867541950042 0.00323668848100741 no 43 0.00317946295748519 18 1222756 SGTC_1118 chelidonine 707.474 nM 2.72515820251938 0.0032708136613903 no 44 0.0032135341578267 13 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1242 0402-0103 60.1 µM 2.67899222976442 0.00374970618927242 no 45 0.00369220537198298 26 432868 SGTC_2969 9091408 28.7 µM 2.67244035145618 0.00382254000167006 no 46 0.00376508802843453 31 4286311 SGTC_2334 9017922 200 µM 2.6721591198765 0.00382569449931301 no 47 0.00376824510671564 19 3163164 SGTC_1378 2093-0007 380 nM 2.66432250734434 0.00391453931849539 no 48 0.00385717821998686 28 3618014 SGTC_1301 naphtanilide LB 4.81 µM 2.6320730116155 0.00429992523585872 no 49 0.0042432811555699 37 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.630410599842 0.00432068056821906 no 50 0.00426408983398792 21 75037 A free radical scavenger. SGTC_3052 9092717 49.47 µM 2.62514187414205 0.00438705391308605 no 51 0.00433064346678152 22 25237534 SGTC_2301 7769476 200 µM 2.61888901295612 0.00446700613777195 no 52 0.00441083219605539 34 977820 SGTC_2582 agaric acid 100 µM 2.60246323218198 0.00468326846132627 no 53 0.00462783696138383 59 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1575 cyproterone acetate 48 µM 2.59497479607285 0.00478492511125605 no 54 0.00472989278050615 24 9880 An androgen receptor antagonist and liver toxin. SGTC_2973 9094665 17.96 µM 2.58841543420949 0.00487558107431726 no 55 0.00482093091971195 50 25237061 YIL048W NEO1 SGTC_1136 pergolide 1.05886 µM 2.56178763173858 0.00525951809213638 no 56 0.00520674863576512 48 47811 A dopamine receptor agonist. SGTC_283 0987-0079 11.7 µM 2.55073786666526 0.00542658188898136 no 57 0.00537475711460238 12 411556 SGTC_2697 mebhydrolin 72.4 µM 2.53924104077633 0.00560539578201937 no 58 0.00555466270885915 27 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1392 3455-1037 33.9 µM 2.53054035394723 0.00574417939001785 no 59 0.0056943491778831 22 981132 SGTC_2725 haloperidol 53.21 µM 2.52783130678823 0.00578800933420878 no 60 0.00573847410594849 43 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_536 3852-0578 10.6 µM 2.51300777017361 0.00603313564933159 no 61 0.00598533491587099 22 2869208 SGTC_2329 6138490 200 µM 2.507979178445 0.00611835592733161 no 62 0.00607119109501789 40 720019 SGTC_2260 7964312 200 µM 2.45301407616975 0.0071217395354492 no 63 0.00708323974976751 32 231951 SGTC_2318 6029776 164 µM 2.44204303340024 0.00733856537720037 no 64 0.00730220281990936 34 818325 SGTC_1238 0333-0287 48.8 µM 2.437698200105 0.00742603002455448 no 65 0.00739055436786263 19 7226 SGTC_2413 inermin 26.06 µM 2.43275096226788 0.00752673880904351 no 66 0.00749230161831944 57 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3253 9135987 49.47 µM 2.42912101902314 0.00760139524665271 no 67 0.00756773965091724 30 4182430 SGTC_2793 7325131 81.82 µM 2.42501545112687 0.0076866188976598 no 68 0.00765386761524451 29 4176441 SGTC_491 tetrandrine 80.3 µM 2.42080227646648 0.00777494957784751 no 69 0.00774314900873163 25 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.40863713174757 0.00803502837086187 no 70 0.00800610476256903 29 66535 A nucleotide analog. SGTC_2461 5755302 26.15 µM 2.40602863951459 0.00809178089350873 no 71 0.00806350019122701 26 2788904 SGTC_1435 4092-0789 56.7 µM 2.38957594973881 0.00845792486428236 no 72 0.00843391792038246 34 2248285 SGTC_3321 9137793 26.8275 µM 2.38782460399848 0.0084977434237622 no 73 0.00847421412666953 53 4904192 SGTC_1802 st050112 57.9 µM 2.37665400732956 0.00875561009661129 no 74 0.00873523334195198 25 4662563 SGTC_2900 5328528 85.29 µM 2.36087052688175 0.00913164822868912 no 75 0.00911604736201305 33 795359 SGTC_611 3453-1652 23.7 µM 2.35700105891714 0.00922596791639012 no 76 0.00921159716193237 59 1560575 SGTC_275 trichlorophene 5.69 µM 2.34163797564749 0.00960891247248135 no 77 0.00959966397883927 22 62616 SGTC_3348 9149464 3.537 µM 2.34067287978959 0.00963342591991656 no 78 0.00962451216363301 16 1951442 SGTC_785 1270-0111 65.3 µM 2.33717328794737 0.00972277460194776 no 79 0.00971508775593856 35 6741994 SGTC_1813 st051246 8.6015 µM 2.33589247827401 0.00975565569339464 no 80 0.00974842304371592 20 5291959 SGTC_1787 fluconazole 80 µM 2.33340139171431 0.0098198854438381 no 81 0.00981354415102262 40 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1638 st008370 60.6 µM 2.3311882928358 0.00987725711205793 no 82 0.00987171659532163 44 24207134 SGTC_1262 0737-0114 49.6 µM 2.3214901044384 0.0101321351656798 no 83 0.0101302037773687 35 765919 SGTC_1292 0kpi-0043 232 µM 2.3190566417715 0.0101969825409945 no 84 0.0101959826546797 28 3333905 SGTC_1006 4099-6547 255 µM 2.31525498060207 0.0102990145143642 no 85 0.0102994909721269 37 3146833 SGTC_1529 apigenin 74 µM 2.30460996348794 0.0105894642209987 no 86 0.0105942137299368 29 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2934 9036370 36.88 µM 2.30078612525784 0.0106955261789924 no 87 0.0107018615437851 29 6462800 SGTC_2432 5630864 12.22 µM 2.27946697501205 0.0113039736300452 no 88 0.0113196604813043 42 5714970 SGTC_3284 9108171 64.8615 µM 2.27228480781347 0.0115156191533715 no 89 0.0115346568994566 35 8687505 SGTC_2529 gangaleoidin 93.61 µM 2.26928720563171 0.0116049659961733 no 90 0.0116254330374946 25 4565183 SGTC_2592 piperlongumine 83.33 µM 2.24259124720055 0.0124275714512533 no 91 0.0124615925968121 41 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2608 thymoquinone 42.66 µM 2.24168891441223 0.0124562365196825 no 92 0.0124907424223958 34 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2890 9046729 58.44 µM 2.23832097502322 0.0125637345857318 no 93 0.0126000656263331 56 903329 SGTC_2661 dactinomycin 12.96 µM 2.23371903749666 0.0127119173053398 no 94 0.0127507827847505 34 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3080 9117754 49.47 µM 2.21152646587118 0.0134479379195811 no 95 0.0134997006140751 43 9550191 SGTC_1526 st051518 75 µM 2.20117160341499 0.0138037637390451 no 96 0.0138619388866715 31 673993 SGTC_946 3434-1334 87.4 µM 2.19318335094195 0.0140837863014208 no 97 0.0141470857938232 46 4047976 SGTC_740 k014-0057 261 µM 2.19180582146717 0.0141325662615664 no 98 0.0141967652976717 46 4012779 SGTC_2511 berberine 10.47 µM 2.18446801117757 0.0143948671928309 no 99 0.0144639376953081 41 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1144 3486-0183 12.5 µM 2.17491993311237 0.0147424449793603 no 100 0.0148180584510164 40 6744069 SGTC_2043 5101342 149 µM 2.15699583440986 0.0154144571942184 no 101 0.0155029945070612 41 678451 SGTC_3165 9101544 49.47 µM 2.14989230310666 0.0156879702644382 no 102 0.0157818673008613 39 5002184 SGTC_1382 3002-2117 298 µM 2.13658782956384 0.0162114554775406 no 103 0.0163157651852426 28 1497314 SGTC_1226 3909-7979 35.4 µM 2.13547896742649 0.0162557532552327 no 104 0.0163609532038486 58 6615510 SGTC_2377 9073351 62.6 µM 2.12450197435597 0.0166998932932792 no 105 0.0168140955668099 47 7337946 YHR072W ERG7 SGTC_3218 9131285 49.47 µM 2.11950113280473 0.0169056499179715 no 106 0.0170240690616412 50 17156417 SGTC_3330 9141424 71.43 µM 2.1160689803797 0.0170481148727163 no 107 0.0171694706191385 35 27261020 SGTC_2541 muurolladie-3-one 83.07 µM 2.10786852696268 0.0173926676351651 no 108 0.0175211816421143 82 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3152 9099253 49.47 µM 2.10383722898257 0.0175642168973187 no 109 0.0176963240326338 86 25236131 SGTC_1981 st071826 47 µM 2.09946859769451 0.0177517497883672 no 110 0.0178878065923567 52 11838600 SGTC_1294 1000-1494 117 µM 2.09177969411752 0.0180859626656101 no 111 0.0182291138142016 40 712797 YDL207W GLE1 SGTC_1657 st012939 43.4 µM 2.08967140213567 0.0181785352555549 no 112 0.0183236638187993 23 24207257 SGTC_569 4130-2812 160 µM 2.08469993423181 0.0183984265331971 no 113 0.0185482733201471 42 743552 SGTC_1202 1988-0068 29.6 µM 2.08012720721829 0.018602677528606 no 114 0.0187569333467385 47 2850480 SGTC_1446 4239-0190 62 µM 2.0637175467188 0.0193516178596805 no 115 0.0195222523453744 56 1340085 SGTC_31 0508-1974 57.237 µM 2.05577984756044 0.0197229947181115 no 116 0.0199018706800117 34 6810525 SGTC_1643 st009866 20.2 µM 2.04800740533144 0.0200924850806955 no 117 0.0202796368965112 54 3156273 YOR207C RET1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.04426404672146 0.020272523191991 no 118 0.0204637345116878 50 5379071 SGTC_1870 st057514 26.5 µM 2.04415491719745 0.020277792264146 no 119 0.020469122654349 44 5393161 SGTC_850 0388-0143 75.9 µM 2.0419230130731 0.0203858096556252 no 120 0.0205795843026587 36 67273 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.0392492202981 0.0205158547946728 no 121 0.0207125804044412 43 551469 SGTC_1881 5652484 16 µM 2.03240230653667 0.0208520760185311 no 122 0.0210564723938121 50 2255129 SGTC_3092 9117248 49.47 µM 2.02691253700423 0.0211250126412145 no 123 0.0213356790786086 29 17141857 SGTC_717 1532-0246 73.2 µM 2.00195849870967 0.0224040532111045 no 124 0.0226445976012776 52 9561992 SGTC_1977 st070720 65.3 µM 1.98991881994973 0.0230441494971635 no 125 0.0232999394194559 24 682188 SGTC_1112 tnp00069 1.16933 µM 1.98521418829477 0.0232984250957127 no 126 0.0235603232059536 41 145826 SGTC_1032 k061-1018 98.7 µM 1.98464760262224 0.0233292066023818 no 127 0.0235918461125966 48 4005393 SGTC_182 3448-4371 550.524 µM 1.97394198875682 0.0239172855734334 no 128 0.0241941698066348 38 3491403 SGTC_2906 7926292 26.41 µM 1.96274359541768 0.0245457162162573 no 129 0.0248379873751502 45 2966319 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.96225124997974 0.0245736606875624 no 130 0.0248666199201611 45 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_178 4092-0806 87.505 µM 1.95936820011212 0.0247378328323641 no 131 0.0250348409986558 68 2169044 SGTC_208 k072-0098 12.366 µM 1.95679707794764 0.0248850177917078 no 132 0.0251856653855432 74 5948901 SGTC_2940 9060638 45.86 µM 1.94434417914524 0.0256083202644791 no 133 0.0259269802186118 49 4027022 SGTC_2858 9025781 8.96 µM 1.93731145642263 0.0260245229995105 no 134 0.0263536413393162 65 4894980 YPL153C RAD53 SGTC_1120 ficusin 1.78878 µM 1.93654941380865 0.0260699592186619 no 135 0.0264002233419111 52 6199 A DNA cross-linker. SGTC_2747 doxorubicin 7.63 µM 1.93205517131216 0.0263392765065129 no 136 0.0266763482988748 31 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1249 0481-0015 10.2 µM 1.92154909787014 0.0269779350139752 no 137 0.0273312593987183 63 4227577 SGTC_95 0471-0001 561.058 µM 1.92132632852518 0.026991615764558 no 138 0.027345289946517 52 4015405 SGTC_2267 7931562 200 µM 1.92086543872624 0.0270199383942245 no 139 0.0273743369625623 49 934880 SGTC_129 0088-0017 176.636 µM 1.91936412716872 0.0271123691346961 no 140 0.0274691337675482 43 182446 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.91640550168902 0.0272952942163501 no 141 0.0276567505398989 64 5024745 SGTC_155 k072-0202 43.6 µM 1.91345569086384 0.0274786979960163 no 142 0.0278448703710777 63 5857737 SGTC_2291 7917025 104.35 µM 1.89388297539048 0.0287218238041733 no 143 0.0291202723585601 57 2964612 SGTC_211 3455-0679 143.504 µM 1.89204503378692 0.02884092198102 no 144 0.0292424904397555 48 748649 SGTC_2798 7813637 45.45 µM 1.89021517196368 0.0289599041440798 no 145 0.0293645941820173 84 956368 SGTC_1569 carminic acid 40.6 µM 1.88077940155906 0.0295799345036192 no 146 0.0300009666571702 47 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_222 nsc-310342 10.666 µM 1.87832294433984 0.0297431452413435 no 147 0.0301684998057791 40 432556 SGTC_1093 fluphenazine 7.97 µM 1.87725841435794 0.0298141059223714 no 148 0.0302413424326311 54 6602611 An atypical antipsychotic. SGTC_2721 ifenprodil 61.44 µM 1.86025049092297 0.0309670143925891 no 149 0.0314250472817985 66 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2109 5483026 200 µM 1.85249681197753 0.031504723404698 no 150 0.0319772574645767 117 759335 SGTC_378 3970-0959 8.33 µM 1.84949907400173 0.0317146715432577 no 151 0.0321928906951749 63 6615653 SGTC_2297 7971671 152.32 µM 1.84670041509263 0.031911719199492 no 152 0.0323952857577217 62 909016 SGTC_2036 5160441 105 µM 1.84201226944932 0.0322440666656368 no 153 0.0327366775967232 90 134534 YIL048W NEO1 SGTC_848 0368-0089 85.6 µM 1.83965699089369 0.0324121098785029 no 154 0.0329093058112836 61 762535 SGTC_323 4013-0906 34.3 µM 1.83832052315392 0.0325077843997612 no 155 0.0330075943295429 46 2910086 SGTC_2430 5571206 200 µM 1.8322161033697 0.032947751880353 no 156 0.0334596153099459 84 1731771 SGTC_722 3534-0461 190 µM 1.83164208431874 0.0329893747392188 no 157 0.0335023812495577 51 658262 SGTC_3226 9131256 49.47 µM 1.82667358726638 0.0333514605873719 no 158 0.0338744309151213 36 17178073 SGTC_2782 7736369 71.43 µM 1.81614303270761 0.0341297120552661 no 159 0.0346742170235395 77 2950836 YOL077C BRX1 SGTC_147 4466-0538 29.23 µM 1.81486562576405 0.0342251250424316 no 160 0.034772281100837 70 6742687 YHR072W ERG7 SGTC_1342 1486-1464 234 µM 1.81112861904214 0.0345055118378637 no 161 0.0350604721838595 63 3253938 SGTC_1905 st060207 84.5 µM 1.80953308585882 0.0346257978500793 no 162 0.0351841124233499 73 1948547 SGTC_2514 salinomycin 42.74 µM 1.80635342302519 0.0348665372661422 no 163 0.0354315760132923 63 23682228 A polyether potassium ionophore. SGTC_1649 st011737 51.3 µM 1.79561218309975 0.0356899608563635 no 164 0.0362781084624852 52 1761035 SGTC_1620 st003704 16.5 µM 1.79532123492244 0.0357124847627718 no 165 0.0363012668329311 69 2834414 SGTC_1109 tnp00067 928.257 nM 1.79379567227221 0.0358307777596375 no 166 0.0364228939847257 54 676295 SGTC_2663 amphotericin b 100 µM 1.79017777982337 0.0361125950027598 no 167 0.0367126680106881 88 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1613 st002381 52.1 µM 1.78963958782611 0.036154672367212 no 168 0.0367559350147626 66 551167 SGTC_3157 9099274 49.47 µM 1.78852103707603 0.0362422522342207 no 169 0.0368459923524203 58 17217662 SGTC_2636 apigenin dimethyl ether 100 µM 1.7826544777178 0.0367044384047594 no 170 0.0373212829427939 66 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_8 0354-0001 70 µM 1.7691146814203 0.0377895639256451 no 171 0.0384373691651846 82 4993152 SGTC_2338 7999974 200 µM 1.76887848191822 0.0378087236423779 no 172 0.0384570779371586 79 315925 SGTC_2639 lactacystin 53 µM 1.76824280540521 0.037860326985225 no 173 0.0385101604704413 70 3870 A proteasome inhibitor. SGTC_2690 usnic acid 100 µM 1.76440087766974 0.038173434041042 no 174 0.0388322552603029 69 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3239 9133757 49.47 µM 1.7623389490182 0.0383423447088373 no 175 0.0390060234516283 41 17036923 SGTC_1009 4106-0057 9.87 µM 1.75115747290987 0.0392689586356079 no 176 0.0399593942993444 80 2928005 SGTC_3188 9110789 49.47 µM 1.75095775952127 0.0392856731767829 no 177 0.0399765931638466 75 849217 SGTC_1278 0874-0585 172 µM 1.72928758444906 0.0411339891469713 no 178 0.0418788187931826 71 766306 SGTC_705 1124-0212 310 µM 1.7265497315344 0.0413724460611059 no 179 0.0421242802477607 88 9554485 SGTC_230 MPP+ 141.667 µM 1.7217197844528 0.0417958474757806 no 180 0.0425601458058387 77 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_495 decylubiquinone 155 µM 1.70981641889558 0.0428543079517876 no 181 0.0436499129382689 68 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2311 7694451 200 µM 1.69488229779798 0.0442127922127669 no 182 0.0450488756428755 107 2163142 SGTC_2997 9067075 71.4286 µM 1.69127035995165 0.0445465124766502 no 183 0.0453925891425389 96 27209819 SGTC_967 1306-0166 352 µM 1.69078241335977 0.0445917508392702 no 184 0.0454391836338557 84 4437607 SGTC_845 0330-0138 4.51 µM 1.66375116176835 0.0471562221773438 no 185 0.0480810837323018 79 9039800 SGTC_2924 9010168 62.78 µM 1.66155317090972 0.0473698411019425 no 186 0.0483011997333445 71 2993929 SGTC_3247 9135149 49.47 µM 1.6613554154836 0.0473890985702436 no 187 0.0483210432498833 113 8934436 YOR116C RPO31 SGTC_3187 9109394 49.47 µM 1.65632062343203 0.0478815041687124 no 188 0.048828453086516 95 17098090 SGTC_2968 9090663 33.37 µM 1.65510293220648 0.0480012081044278 no 189 0.0489518101044094 122 25236811 SGTC_329 k048-0121 21.3 µM 1.65434843314863 0.0480754984955204 no 190 0.0490283687453228 74 6832902 SGTC_592 k241-0073 46.5 µM 1.64853940093549 0.0486505602351851 no 191 0.0496210161659114 85 4230158 SGTC_1962 st076595 64.5 µM 1.63978811079839 0.0495272568435408 no 192 0.0505246155352566 101 279619 SGTC_394 menadione 8.33 µM 1.63647259567658 0.0498626776459607 no 193 0.0508703582821777 81 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1072 oxiconazole 14.9 nM 1.63354070969409 0.0501607951212302 no 194 0.0511776630130251 99 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_505 gw-5074 63.9 µM 1.62511306251311 0.051025645259519 no 195 0.0520692350373779 86 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2894 9048625 32.47 µM 1.62511039214061 0.0510259211637046 no 196 0.0520695194825901 103 4092861 SGTC_1795 st049545 62.3 µM 1.62420237589802 0.0511198067114617 no 197 0.0521663119917719 55 5291882 SGTC_1254 0550-0035 264 µM 1.62259833693439 0.0512859943206752 no 198 0.0523376481326656 93 15121435 SGTC_157 1348-1695 65.819 µM 1.62046074427665 0.0515081288494633 no 199 0.0525666701856132 114 5380510 SGTC_1061 3448-9325 110 µM 1.61895806675988 0.0516647416827191 no 200 0.0527281428951847 97 723482 SGTC_2365 9042475 200 µM 1.61643964130412 0.0519280669727448 no 201 0.052999646731411 80 6464479 SGTC_1587 estradiol valerate 56.1 µM 1.61156755842294 0.0524405159027377 no 202 0.0535280374804607 93 13791 A steroid. SGTC_664 1222-0054 14.9 µM 1.60957225165385 0.0526515388907263 no 203 0.0537456349983522 98 6813991 SGTC_2050 5263056 171 µM 1.60349369098728 0.0532985609893993 no 204 0.0544128504576663 111 763468 YGL055W OLE1 SGTC_3328 9140624 29.0385 µM 1.60000691289882 0.0536725399225071 no 205 0.0547985249192914 86 4904392 SGTC_3013 9080133 71.4286 µM 1.59952214775708 0.0537246982140557 no 206 0.0548523157347185 77 17050193 SGTC_3267 9137951 49.47 µM 1.58748759143696 0.0550324704551298 no 207 0.0562011275600789 75 16643986 SGTC_334 1502-1024 68.5 µM 1.5869982632739 0.0550861723155669 no 208 0.0562565189841287 64 3296216 SGTC_2208 7283366 200 µM 1.58633641984807 0.0551588729134136 no 209 0.0563315074174455 77 898663 SGTC_2517 totarol 10 µM 1.58486684074445 0.0553205707186467 no 210 0.0564982959358001 70 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1775 st081588 35.1725 µM 1.58100202400509 0.0557476035555146 no 211 0.0569387874758017 94 1426443 YGL099W LSG1 SGTC_1625 st003711 30.1 µM 1.5737777936677 0.0565527975275601 no 212 0.0577694147938882 89 24207034 YER133W GLC7 SGTC_1286 0929-0070 131 µM 1.57300786616191 0.0566391492828663 no 213 0.0578584984038688 90 1420408 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.57296486992364 0.0566439746167203 no 214 0.0578634764179849 128 16725076 SGTC_2646 retinol 96.75 µM 1.56850399541068 0.0571463669641219 no 215 0.0583817791308094 99 445354 A vitamin A analog and teratogen. SGTC_2976 9009005 19.48 µM 1.56409678571349 0.0576461532130783 no 216 0.0588974203606721 57 2993148 SGTC_2290 7904846 200 µM 1.56072511264676 0.0580308233080505 no 217 0.059294311693142 97 2962154 SGTC_1887 st057648 70.8 µM 1.55686266450828 0.0584739612335799 no 218 0.0597515476873179 111 688672 SGTC_452 diindolylmethane 8 µM 1.55464911384677 0.0587291166944562 no 219 0.060014829951065 73 3071 Inhibits expression of several cancer promoting factors. SGTC_328 k915-0120 63.5 µM 1.55279836784281 0.0589431218252342 no 220 0.0602356563834986 66 6624543 SGTC_2777 climbazole 1.536 µM 1.55060750221726 0.0591972459015246 no 221 0.0604978865868104 101 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1716 st033144 30.6155 µM 1.54856880812326 0.0594344902359145 no 222 0.0607427044983436 88 674617 SGTC_2001 4023502 57.655 µM 1.54734284949739 0.0595775144108939 no 223 0.060890297175612 80 108941 YCR052W RSC6 SGTC_2404 5161160 200 µM 1.54352438599902 0.0600247171973752 no 224 0.0613517976915768 123 2831543 SGTC_2133 5320837 200 µM 1.53725045520481 0.0607651968040055 no 225 0.0621159945114646 65 2841355 SGTC_3099 9120367 49.47 µM 1.53449475411018 0.0610926875328211 no 226 0.0624539914162221 86 24824940 SGTC_161 4065-0411 162.148 µM 1.53218345561225 0.061368427283784 no 227 0.0627385849964417 96 1906281 YLR208W SEC13 SGTC_2832 7992762 51.95 µM 1.53153580192867 0.0614458670129399 no 228 0.0628185125499912 89 2985177 SGTC_2049 5262831 67.185 µM 1.53067883178383 0.0615484519325826 no 229 0.0629243939692027 93 763417 SGTC_2112 5488546 200 µM 1.53028227468608 0.0615959676493567 no 230 0.0629734369046868 98 600757 SGTC_2978 9011784 42.97 µM 1.5284641796778 0.0618141797219416 no 231 0.0631986652938558 80 2994934 SGTC_2349 9023730 187.07 µM 1.52125670914619 0.0626851798666134 no 232 0.0640977146989946 80 4126287 SGTC_3193 9111931 49.47 µM 1.51705023787416 0.0631979215170338 no 233 0.0646270003083976 96 17087244 SGTC_1361 1608-0041 5.61 µM 1.51701195813207 0.0632026025199182 no 234 0.06463183245413 96 X1361 SGTC_2478 5763493 32.33 µM 1.51353800837123 0.063628536338538 no 235 0.0650715270854765 87 1365576 YLR208W SEC13 SGTC_119 0121-0043 24.815 µM 1.51277149078163 0.0637228175662017 no 236 0.0651688564265388 136 1092378 SGTC_639 0833-0042 114 µM 1.51249733474902 0.0637565649767323 no 237 0.0652036950779742 113 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2385 9074692 200 µM 1.51234647561907 0.0637751410060853 no 238 0.0652228718152749 86 17046906 SGTC_757 1066-0008 322 µM 1.51052422494605 0.0639998564286495 no 239 0.0654548563908955 96 6842497 SGTC_481 bay k-8644 50 µM 1.51041711381727 0.0640130842405677 no 240 0.0654685122344339 98 2303 A calcium channel antagonist. SGTC_2830 7992007 71.43 µM 1.50830213797832 0.0642747112429882 no 241 0.065738608148346 102 1952075 SGTC_288 1315-0019 35.1 µM 1.50090880070732 0.0651958167478058 no 242 0.0666895757943052 135 6811474 SGTC_1922 5578187 25 µM 1.49773016680443 0.0655949642731577 no 243 0.0671016853921544 101 1350412 SGTC_2897 9048598 12.99 µM 1.49640769303593 0.0657615870971867 no 244 0.0672737230158885 65 6467404 SGTC_2817 7995342 71.43 µM 1.4915053350092 0.0663821148163822 no 245 0.0679144357897466 94 18879975 SGTC_2090 5301565 104.445 µM 1.48964215000865 0.066619137400879 no 246 0.0681591764868182 109 2056344 SGTC_3082 9117008 49.47 µM 1.4882287328631 0.0667993798921527 no 247 0.0683452911127974 93 41448529 SGTC_2823 7987624 58.44 µM 1.48673370071025 0.0669904405192724 no 248 0.0685425790727482 113 2239440 SGTC_678 1218-2179 85.9 µM 1.48483404678015 0.0672338200288026 no 249 0.0687938952445712 88 6820081 YOR116C RPO31 SGTC_1092 toremifene 6.32 µM 1.48349428819543 0.0674058776516935 no 250 0.0689715664416676 102 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2868 9035608 32.47 µM 1.48337675350595 0.0674209881902238 no 251 0.0689871700862629 87 6462614 SGTC_1295 1013-0063 9.78 µM 1.48216796219707 0.0675765452272102 no 252 0.0691478044626308 98 6826038 SGTC_2193 5925765 200 µM 1.47553216711127 0.0684354374771207 no 253 0.0700347633751755 88 877370 SGTC_1165 k072-0275 30.3 µM 1.47476605414764 0.068535137823834 no 254 0.0701377252402042 101 6153523 YGL055W OLE1 SGTC_647 0140-0236 81 µM 1.47071291052234 0.0690644709002381 no 255 0.0706843866076032 91 990837 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.46976726376978 0.0691884227484546 no 256 0.0708123990724511 107 688801 SGTC_674 0498-0004 451 µM 1.4690010887602 0.0692889757476403 no 257 0.0709162469572316 139 4231473 SGTC_2004 4023728 41.89 µM 1.46860241819139 0.0693413418824866 no 258 0.0709703292925114 136 360084 YDR527W RBA50 SGTC_2232 chlorophetanol 41.5365 µM 1.46789240137376 0.0694346794236494 no 259 0.071066726276958 105 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_873 0591-4978 488 µM 1.46048332439411 0.0704144449056587 no 260 0.0720786436309934 105 3305145 SGTC_3246 9135460 32.98 µM 1.46046447518968 0.0704169509819684 no 261 0.0720812320316252 98 41446951 SGTC_568 1193-0097 7.48 µM 1.4594957344219 0.0705458412491457 no 262 0.0722143569080798 125 3646150 SGTC_2664 lyso-paf C-16 73.48 µM 1.45638226403705 0.0709613144111825 no 263 0.0726434878597949 113 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_6 0844-0013 19.835 µM 1.44942495722759 0.0718965133248781 no 264 0.073609471580922 142 1584900 SGTC_2386 9075165 157.42 µM 1.44156803379965 0.0729639698107475 no 265 0.0747121358544615 106 16452277 SGTC_3003 9075612 71.4286 µM 1.44124116341945 0.073008640468764 no 266 0.0747582814521319 101 6501993 SGTC_2093 5331342 194.4 µM 1.44119084687409 0.0730155186714416 no 267 0.0747653867709779 106 33839 SGTC_1992 st073643 23.3 µM 1.43360240314448 0.0740585366613584 no 268 0.0758428786694329 109 3161292 SGTC_1906 st060206 94.7 µM 1.43165095851862 0.0743285904223063 no 269 0.0761218690328551 113 5133468 SGTC_2826 7992541 19.48 µM 1.41988671019556 0.0759725598209778 no 270 0.0778203327848685 111 2985066 SGTC_1080 nisoldipine 24.4 µM 1.4186389459106 0.0761485372727026 no 271 0.0780021526967244 110 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1425 4048-4433 7.33 µM 1.41821583861148 0.0762082802677251 no 272 0.0780638795555799 128 23734946 SGTC_2654 protoveratrine a 100 µM 1.41516551509548 0.0766400438468366 no 273 0.0785099864313366 110 5702278 A heart drug and vasodilator. SGTC_198 3454-2873 16.191 µM 1.41242422680727 0.0770296494270737 no 274 0.0789125435828158 125 710957 SGTC_669 0108-0021 26.2 µM 1.4114879670902 0.0771630596154228 no 275 0.0790503905872649 99 17201 SGTC_3121 9125696 49.47 µM 1.41148106925036 0.0771640431584291 no 276 0.0790514068434724 81 1235365 SGTC_1617 st002906 78 µM 1.41001452191309 0.0773733702769372 no 277 0.079267697481818 106 5150859 SGTC_2379 9035213 200 µM 1.40324444440703 0.0783452896185033 no 278 0.0802719792420194 116 646551 SGTC_1175 0741-0056 27.6 µM 1.39757644143132 0.0791660903380959 no 279 0.0811201484680437 111 765927 SGTC_2326 6164455 177.58 µM 1.3949847756098 0.0795435596033844 no 280 0.0815102152990379 129 2888790 SGTC_3243 9134147 49.47 µM 1.3915703252606 0.0800429423205297 no 281 0.0820262750549827 95 24282180 SGTC_1733 st037357 54.9 µM 1.39146160286465 0.0800588824376192 no 282 0.0820427476968401 128 1272339 YGL099W LSG1 SGTC_1863 st057641 20.1 µM 1.39111792071448 0.0801092864938615 no 283 0.0820948357240826 116 3921635 SGTC_1065 prochlorperazine maleate 2.48 µM 1.38766744165615 0.0806166602252875 no 284 0.0826191673064428 127 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2891 9063876 19.48 µM 1.38429404455104 0.0811150421690312 no 285 0.0831342184234243 83 6472478 SGTC_370 0180-0345 38.7 µM 1.38355066335978 0.0812251804593982 no 286 0.0832480420259273 99 3989527 SGTC_947 3447-0010 211 µM 1.38267542060135 0.0813549997528887 no 287 0.0833822058926163 126 748350 SGTC_2845 9003024 42.97 µM 1.38220228798325 0.0814252416985537 no 288 0.0834547989005761 111 2990173 SGTC_815 1582-0027 36.9 µM 1.3810655238862 0.0815941942856293 no 289 0.0836294074109833 116 3128206 SGTC_3101 9120531 49.47 µM 1.38041203890152 0.0816914386582756 no 290 0.0837299077647686 118 24824904 SGTC_726 3448-4391 34.2 µM 1.37917295234078 0.0818760656053602 no 291 0.0839207176566104 117 1356692 SGTC_2925 9010536 32.5 µM 1.37714462511838 0.0821789698018106 no 292 0.0842337690901482 88 2994177 SGTC_2394 5221648 200 µM 1.3762769856507 0.0823087978886431 no 293 0.0843679476491269 131 788586 SGTC_3280 9140961 49.47 µM 1.37518547879432 0.0824723433809954 no 294 0.0845369745293813 113 4901226 SGTC_1256 0570-0116 285 µM 1.37059402396853 0.0831629819793696 no 295 0.0852507734633814 115 410638 SGTC_2306 7482397 179.52 µM 1.36941396440182 0.0833411849980645 no 296 0.0854349558028129 125 891448 SGTC_3228 9131799 49.47 µM 1.36727309361331 0.0836652144617257 no 297 0.0857698610214894 116 17015818 SGTC_1553 gossypol 38.6 µM 1.36619623097536 0.0838285593378867 no 298 0.0859386900973748 95 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_51 1013-0126 23.419 µM 1.36488629949368 0.0840275802287908 no 299 0.0861443944930666 92 1627850 SGTC_2497 7-hydroxyflavone 100 µM 1.35764345492347 0.0851344102400646 no 300 0.0872884235866195 128 5281894 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.35752814103477 0.0851521201012311 no 301 0.087306729053374 98 140250 A respiratory chain inhibitor. SGTC_2154 5570129 200 µM 1.35370236418864 0.0857412476816055 no 302 0.0879156767888406 112 673366 SGTC_368 fentichlor 4.58 µM 1.35261086571034 0.0859098845897329 no 303 0.0880899896744595 113 7329 A pesticide. SGTC_3300 9124615 50.48 µM 1.35251467804515 0.0859247575111379 no 304 0.0881053632409077 102 24824903 SGTC_2480 5767542 37.17 µM 1.34503725220737 0.0870868529236059 no 305 0.0893066024120556 116 2867358 SGTC_1209 2323-2347 50.3 µM 1.34191054589819 0.0875762517389592 no 306 0.0898125009686009 111 5412760 SGTC_2472 5377652 49.4 µM 1.33993212271575 0.0878869771670027 no 307 0.0901337067619417 138 1610903 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.33862499052687 0.0880927221831306 no 308 0.0903463931756623 144 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1833 st055984 71 µM 1.33644197529227 0.0884371331074827 no 309 0.0907024271108191 108 676288 SGTC_2152 5568786 200 µM 1.33294239393675 0.0889913484511736 no 310 0.0912753544376005 128 5399883 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.33258391621903 0.0890482648517141 no 311 0.0913341930999092 133 688803 SGTC_3048 9093155 49.47 µM 1.33189670424014 0.0891574509583888 no 312 0.0914470671009898 102 25236002 SGTC_2728 chlorpromazine 9.18 µM 1.33186324055524 0.0891627703022266 no 313 0.0914525661224172 104 2726 A thorazine and dopamine antagonist. SGTC_248 streptozotocin 5.23457 mM 1.33105933456372 0.0892906291480432 no 314 0.091584744088686 135 5300 DNA alkylating agent. SGTC_3149 9097855 49.47 µM 1.33065764470695 0.0893545678055611 no 315 0.0916508428232583 105 25236625 YMR079W SEC14 SGTC_838 0109-0203 71.4 µM 1.32908606462458 0.0896050501109516 no 316 0.0919097886262924 112 759422 SGTC_1928 4'-methoxychalcone 40.3 µM 1.32880632818202 0.0896496898796729 no 317 0.0919559369370112 138 641818 SGTC_2072 5231554 129 µM 1.32005394398597 0.0910547422929746 no 318 0.0934085040646449 127 789545 SGTC_1049 3226-0134 66 µM 1.31955656396159 0.0911350762519119 no 319 0.0934915565607227 120 5702385 SGTC_2134 5324836 1.464 µM 1.31582868171787 0.091738856310132 no 320 0.0941157751169024 107 699272 SGTC_3173 9105693 49.47 µM 1.31382575641448 0.0920644779936555 no 321 0.0944524239413985 117 17096658 SGTC_1234 0326-0494 15.5 µM 1.31367200552392 0.092089509066795 no 322 0.0944783028191532 141 1547813 SGTC_2147 5545932 89.7195 µM 1.30924519921433 0.0928123680926638 no 323 0.0952256530323279 146 797404 SGTC_2871 9038510 12.99 µM 1.30924412527278 0.0928125439655955 no 324 0.0952258348658453 157 4945164 SGTC_588 3970-1144 52.9 µM 1.30780823759394 0.0930479111216428 no 325 0.0954691797400785 89 1888707 SGTC_294 k038-0071 157 µM 1.30754844366211 0.0930905429908358 no 326 0.0955132567748962 136 24152826 SGTC_1624 st003710 6.25 µM 1.30606551092247 0.0933341668744428 no 327 0.0957651401745267 109 24207033 SGTC_716 1683-5115 658 µM 1.30444517112714 0.0936009028653049 no 328 0.0960409211400775 138 723597 SGTC_3077 9117319 49.47 µM 1.29311165675908 0.0954823500044337 no 329 0.09798622203695 131 17154678 SGTC_2667 digitoxin 100 µM 1.28605334196452 0.096668063304486 no 330 0.0992122230418093 88 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2936 9038235 15.59 µM 1.28453465860502 0.096924591949306 no 331 0.0994774723643549 132 4749415 SGTC_1454 4239-0054 42.6 µM 1.28361715612735 0.0970798140120449 no 332 0.0996379719405451 132 1340767 SGTC_1369 1866-0067 208 µM 1.28210996999022 0.0973351940124377 no 333 0.0999020360132171 125 3531355 SGTC_1491 4138-0063 26.5 µM 1.28021520134398 0.0976569454415062 no 334 0.100234730562939 117 23883227 SGTC_1676 st018489 23.4 µM 1.27729456604566 0.0981544261179149 no 335 0.100749135672431 116 3696235 SGTC_2916 7875993 68.79 µM 1.2727400837945 0.0989339058689425 no 336 0.101555144387613 133 1299250 SGTC_830 4076-0286 57.8 µM 1.2715923718609 0.0991310442252927 no 337 0.101758994231123 141 6866659 SGTC_2408 sulbentine 18.36 µM 1.26793404024268 0.0997613398053253 no 338 0.102410753314076 142 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_455 paf C-16 10 µM 1.26646657434295 0.100014991182008 no 339 0.102673044563718 125 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2213 7173844 200 µM 1.26644839894749 0.100018135747636 no 340 0.102676296247554 126 892728 SGTC_2840 9008771 71.43 µM 1.26195795736769 0.100797250927152 no 341 0.103481957566882 81 2992978 SGTC_2367 9070478 135.38 µM 1.25296949664026 0.102370073474523 no 342 0.105108403986546 146 572802 SGTC_350 k064-0020 19.8 µM 1.25213730303773 0.102516590429542 no 343 0.105259918524825 134 2790705 SGTC_1609 st001574 46.4 µM 1.24982861467601 0.102923858770868 no 344 0.105681080392704 149 3960012 SGTC_2638 epoxomicin 18 µM 1.24922250349766 0.103030975453515 no 345 0.105791851707144 113 9915668 A protesome inhibitor. SGTC_2605 digitonin 300 nM 1.24822525495004 0.103207393155835 no 346 0.105974288881034 161 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2532 xanthone 78.9 µM 1.24790206184779 0.103264614489288 no 347 0.106033462747872 108 7020 An insecticide. SGTC_1347 1493-0251 600 nM 1.24310658273259 0.104116362023369 no 348 0.106914280190769 138 3986378 SGTC_2989 9073649 71.4286 µM 1.24191952643824 0.104327984886086 no 349 0.107133127435224 159 21367202 SGTC_2423 st077119 87.2 µM 1.24147957416176 0.104406496650819 no 350 0.107214319607586 129 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_457 grayanotoxin iii 135 µM 1.23218468580594 0.10607523607635 no 351 0.108940051290904 155 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1774 st048371 48.465 µM 1.23192919747676 0.106121375229328 no 352 0.108987766779072 175 4242727 SGTC_2424 5537928 59.2 µM 1.23091122125066 0.106305357581232 no 353 0.109178035133307 137 5382802 SGTC_777 1315-0167 517 µM 1.23075420840629 0.106333755546956 no 354 0.109207403393168 125 4221767 SGTC_3053 9095903 49.47 µM 1.22726885936006 0.106965540720615 no 355 0.109860777927864 156 17174018 SGTC_2448 5185112 27.17 µM 1.22464561295502 0.107442836377294 no 356 0.110354387050462 122 5718189 SGTC_1715 st032160 10.2275 µM 1.22188377546806 0.107947005275177 no 357 0.110875790888159 122 5289825 SGTC_1486 3970-0793 4.53 µM 1.21380393228244 0.109431744391639 no 358 0.112411302187223 155 2844330 SGTC_972 1319-0219 195 µM 1.21186122675274 0.109790909892525 no 359 0.112782753199695 152 23903702 SGTC_416 estradiol valerate 100 µM 1.21184058322872 0.109794730985024 no 360 0.112786705002268 150 13791 A steroid. SGTC_1559 coumarin 343 70.1 µM 1.21076027513435 0.109994827988951 no 361 0.112993647026249 121 108770 A hepatotoxic, DNA x-linker. SGTC_2088 5278280 127.392 µM 1.21070314122793 0.110005417735066 no 362 0.113004599042594 135 791502 SGTC_2715 st079500 56.4 µM 1.20930324592034 0.110265116335731 no 363 0.1132731821452 151 28246688 SGTC_2673 kobusone 100 µM 1.20928201526921 0.110269058276687 no 364 0.113277258948104 149 6710676 An epoxy ketone and protein crosslinker. SGTC_1548 st061468 90.8 µM 1.2024626917919 0.111540451280999 no 365 0.114592156230429 123 390799 SGTC_952 1185-0122 232 µM 1.20042614193085 0.111922171305021 no 366 0.114986940558348 125 678600 SGTC_2227 7312221 64.1025 µM 1.19863776278373 0.11225814508462 no 367 0.115334413938132 160 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2044 5102272 200 µM 1.19730640545266 0.112508728056884 no 368 0.115593574342597 144 592666 SGTC_1779 st039427 55 µM 1.19694333093682 0.112577133837876 no 369 0.115664321728336 139 1124498 SGTC_1773 st048542 73.5835 µM 1.19599739827553 0.112755493678048 no 370 0.115848787181483 185 3237138 SGTC_1670 st016595 4.04 µM 1.19581507102783 0.112789895477928 no 371 0.115884366649954 157 597879 SGTC_741 4582-0002 126 µM 1.19353274403079 0.113221162768667 no 372 0.116330398115942 164 2912688 SGTC_2644 guaiazulene 100 µM 1.19219625399423 0.113474250711483 no 373 0.116592150961887 117 3515 A coloring agent. SGTC_533 1222-0222 6.71 µM 1.19013467376436 0.113865437946952 no 374 0.116996731988476 154 3982874 SGTC_3094 9117742 49.47 µM 1.18999068114151 0.113892796575032 no 375 0.117025027379982 178 17149698 SGTC_341 1486-1430 230 µM 1.18892807099093 0.114094837559337 no 376 0.117233986419421 187 2054753 YPL210C SRP72 SGTC_1960 st011366 51.8 µM 1.1878771727813 0.11429490264771 no 377 0.117440902148636 153 3972846 SGTC_995 3931-2021 34.6 µM 1.18698103593585 0.114465702219202 no 378 0.117617550434853 144 730143 SGTC_2944 9067346 25.62 µM 1.18588655291522 0.114674552027227 no 379 0.117833552143132 158 6473075 SGTC_3125 9127534 49.47 µM 1.18546197204952 0.114755643718128 no 380 0.117917420821725 121 1639235 SGTC_1842 st055362 61.2 µM 1.18524206698998 0.114797659933245 no 381 0.117960875897695 135 676032 SGTC_1758 st042942 75.2445 µM 1.18388732333494 0.115056745774177 no 382 0.118228834438502 154 669317 SGTC_1284 0929-0043 16 µM 1.18306568856283 0.115214080453627 no 383 0.118391557400985 152 1239883 SGTC_958 1222-0007 33 µM 1.1818855078568 0.115440340558171 no 384 0.118625566515651 156 7312461 SGTC_782 0083-0095 30.5 µM 1.1804816603895 0.115709892232569 no 385 0.118904350186206 143 3591729 An indicator and reagent. SGTC_1546 5-methoxyflavanone 78.7 µM 1.18011582609807 0.115780209163883 no 386 0.118977075490063 127 147795 SGTC_2641 levomentholum 100 µM 1.17793316660329 0.116200368363954 no 387 0.119411625713349 137 16666 SGTC_210 3551-0445 56.827 µM 1.17698124749903 0.116383950045108 no 388 0.119601495556397 137 2865180 YOR207C RET1 SGTC_2882 9058044 58.44 µM 1.17638581529628 0.116498886250499 no 389 0.119720368704115 149 18076804 SGTC_2162 5663267 200 µM 1.17565492866859 0.116640079240187 no 390 0.119866398089804 147 6456493 SGTC_3085 9117376 49.47 µM 1.17386792544336 0.11698580419386 no 391 0.120223965760222 158 16480349 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.17376962953663 0.117004842190991 no 392 0.120243655911813 155 7104 SGTC_977 1348-1378 135 µM 1.16976120666547 0.117783066414401 no 393 0.121048539586093 167 X977 SGTC_821 1114-0266 29.2 µM 1.16804047426173 0.118118263096348 no 394 0.121395219605371 150 3123235 SGTC_1497 4476-2978 41.3 µM 1.16802000005947 0.118122255504537 no 395 0.121399348789405 143 1528379 SGTC_1847 st056231 15 µM 1.1678651530588 0.118152453296755 no 396 0.121430581128674 144 5393180 SGTC_29 0299-0004 12.984 µM 1.16488297482523 0.118735093949904 no 397 0.122033182941592 118 16871 A napthoquinone isolated from Swertia calycina. SGTC_2732 terfenadine 20 µM 1.16194949723783 0.119310197171384 no 398 0.122627989840094 165 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1903 st060211 78.3 µM 1.15874344940558 0.11994098249318 no 399 0.123280387248761 150 688960 SGTC_2729 fluphenazine 10.66 µM 1.15730353205048 0.120225047854817 no 400 0.123574185494372 166 3372 An atypical antipsychotic. SGTC_2645 abamectin 100 µM 1.15563468314511 0.120554869236451 no 401 0.123915307600974 159 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_840 0245-0196 390 µM 1.15479125561904 0.12072180139295 no 402 0.124087959418707 143 3827528 SGTC_1975 st070967 30.8 µM 1.14972197010876 0.121728548338491 no 403 0.125129201229209 197 261391 SGTC_888 0916-0002 6.97 µM 1.14959039869615 0.121754756390479 no 404 0.125156307268678 131 2802138 YIL048W NEO1 SGTC_2373 9071805 200 µM 1.14936655776825 0.121799352956863 no 405 0.125202431882865 147 10149009 SGTC_439 amiodarone 34.4 µM 1.14786836510734 0.122098138295055 no 406 0.125511454734661 150 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_571 k831-0106 44.2 µM 1.14556864248409 0.122557773870315 no 407 0.125986839100846 162 4783639 SGTC_132 0417-1715 25.805 µM 1.14518706912266 0.122634154551609 no 408 0.12606583685171 147 6769098 SGTC_2458 5808907 16.39 µM 1.14322147419316 0.12302814262757 no 409 0.126473324267421 167 2731747 SGTC_413 propylparaben 100 µM 1.14278631466913 0.123115486772825 no 410 0.126563661094141 156 7175 A pharmaceutical preservative. SGTC_3175 9106517 49.47 µM 1.14268161621661 0.123136508072728 no 411 0.126585402647845 152 41468073 SGTC_2787 5284540 71.43 µM 1.14185716269312 0.123302129317583 no 412 0.126756698564469 157 736958 SGTC_1277 0873-0036 22 µM 1.13828961983629 0.124020597796932 no 413 0.127499783475435 153 5965735 SGTC_676 falcarinol 140 µM 1.13654061192718 0.124373899110855 no 414 0.127865189425823 169 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1891 st059073 26.2 µM 1.13006325437698 0.125688459177711 no 415 0.129224785932984 177 688754 SGTC_2132 5317594 122.667 µM 1.12903186372646 0.125898668111634 no 416 0.129442196146021 166 794577 SGTC_2374 9071832 200 µM 1.12819999498876 0.126068390778849 no 417 0.129617733028583 139 17381698 SGTC_1472 k841-0093 193 µM 1.12768919879538 0.126172685380605 no 418 0.129725600422086 153 X1472 SGTC_476 mead acid 10 µM 1.12617191237124 0.126482840216386 no 419 0.130046379939423 143 5312531 An omega 9 fatty acid. SGTC_3143 9086658 49.47 µM 1.1251475002156 0.126692544691663 no 420 0.130263267878777 184 25236626 SGTC_729 4092-0585 94.1 µM 1.1228613485066 0.127161409001046 no 421 0.130748192644996 142 2169061 SGTC_747 3448-8087 38.7 µM 1.12278462056624 0.127177165961384 no 422 0.130764489329178 143 5168703 SGTC_2253 7938677 135.83 µM 1.12247161198425 0.127241459929237 no 423 0.130830985551096 132 2301972 SGTC_2575 plumbagin 510 nM 1.12233457356492 0.127269615614334 no 424 0.130860105644627 165 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1432 4049-0298 68.4 µM 1.12196586333838 0.127345391719527 no 425 0.13093847727101 143 741646 SGTC_1831 st055328 12 µM 1.12193594766239 0.127351541266309 no 426 0.130944837454155 155 1103068 SGTC_3132 9126706 49.47 µM 1.12148286129071 0.127444704173661 no 427 0.131041191390458 174 850858 SGTC_3345 9148410 3.559 µM 1.12130106716989 0.127482097715092 no 428 0.131079865730842 160 4903596 SGTC_1635 st007035 42.4 µM 1.11721543966808 0.128324490336106 no 429 0.131951110301482 156 3716403 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.11529474032836 0.128721841177934 no 430 0.132362069292009 174 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1428 4049-0204 61.7 µM 1.11481690971125 0.128820826382367 no 431 0.132464444342446 176 X1428 SGTC_2536 dehydroabietamide 32.04 µM 1.11189618994745 0.129427017064206 no 432 0.133091393536894 135 3983547 SGTC_1178 0988-0033 191 µM 1.11154104058244 0.129500862306761 no 433 0.133167767418641 151 5392207 SGTC_2052 5265182 7.135 µM 1.11133626026533 0.129543454987551 no 434 0.133211818562136 160 1239884 SGTC_804 1595-0054 20.9 µM 1.1091782683057 0.129992890224369 no 435 0.133676642792754 168 761523 Stimulates phospholipase C. SGTC_3287 9117173 37.0625 µM 1.10822831035768 0.130191075416792 no 436 0.133881613627996 118 2789709 SGTC_101 0490-5701 117.494 µM 1.10764780892413 0.130312285525761 no 437 0.134006973724597 134 4661669 SGTC_1991 st073000 8.92 µM 1.10557158435385 0.130746445091754 no 438 0.134455997307588 173 4301969 YIL048W NEO1 SGTC_2876 9059903 25.97 µM 1.1030492031781 0.131275244447053 no 439 0.135002899209225 144 6916095 SGTC_1429 4049-0205 9.46 µM 1.10113835400445 0.131676822421251 no 440 0.135418223304042 146 22774478 SGTC_531 3788-1495 174 µM 1.09877114277321 0.132175482500929 no 441 0.135933951119636 144 2896655 SGTC_2305 7443522 69.23 µM 1.09803537394853 0.132330739272053 no 442 0.136094521537181 164 5415886 SGTC_1510 1123-0200 71.5 µM 1.09718090061108 0.132511201931072 no 443 0.136281160292922 187 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_271 rotenone 740 µM 1.09550027106716 0.132866641308546 no 444 0.136648763414129 152 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2012 4023501 200 µM 1.09471438691456 0.133033074429443 no 445 0.136820891835472 178 3477460 SGTC_638 3970-0837 4.09 µM 1.09360352936028 0.133268574529367 no 446 0.137064450328523 135 4118451 YLR208W SEC13 SGTC_1396 3511-0007 98.6 µM 1.0902829425518 0.133974243415993 no 447 0.137794263327632 173 X1396 SGTC_2153 5569715 200 µM 1.08652883202598 0.134775129193172 no 448 0.138622546048418 173 2054701 SGTC_1457 k015-0032 57.3 µM 1.08638488609524 0.134805903255012 no 449 0.138654372729372 161 4302660 SGTC_523 1934-0222 13.7 µM 1.08409660297001 0.135295760640798 no 450 0.139160984441899 178 1361595 SGTC_597 k018-0003 82.8 µM 1.08318373374695 0.135491520461986 no 451 0.139363439129633 172 6786234 SGTC_931 2812-0076 566 µM 1.07841027403701 0.136518323152071 no 452 0.140425352017176 163 3450959 SGTC_917 harmaline 728.087 nM 1.07772091341723 0.13666704780286 no 453 0.140579161280945 161 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2240 6690706 185.951 µM 1.07716488997505 0.136787086590711 no 454 0.14070330380849 144 805876 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.07455068732695 0.137352427450237 no 455 0.141287969920886 171 16623 A steroid. SGTC_802 4112-3352 742 µM 1.07422964707027 0.137421964651923 no 456 0.141359883914889 158 704594 SGTC_2708 st078559 56 µM 1.07309739283618 0.137667402363333 no 457 0.141613710327859 139 17250902 SGTC_1685 st024049 53.0905 µM 1.07209665093569 0.137884581187321 no 458 0.141838311484436 164 1941139 SGTC_2062 5245942 200 µM 1.07184999135639 0.137938146595993 no 459 0.141893707475692 159 1376160 SGTC_1865 st057639 52.2 µM 1.07154042323155 0.13800539351633 no 460 0.141963252497539 184 688818 SGTC_1827 berberine 7.24 µM 1.07042738228755 0.138247362081769 no 461 0.142213489718563 144 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1066 ketoconazole 628 nM 1.06920883140668 0.13851259935984 no 462 0.142487790079567 175 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_689 0833-0039 98 µM 1.06818719583717 0.138735241901783 no 463 0.142718039664483 184 5374726 SGTC_771 0250-0039 27.3 µM 1.06579857087203 0.139256739871745 no 464 0.143257353547201 184 3005115 SGTC_1285 0929-0069 65.5 µM 1.06538609990539 0.139346927722548 no 465 0.143350622172577 146 1206237 SGTC_2443 5493264 126.67 µM 1.06257521224339 0.139962593687848 no 466 0.143987316513224 179 5340055 SGTC_1029 k015-0030 64.7 µM 1.0580590079457 0.140955639243326 no 467 0.145014270646767 175 2208316 SGTC_2759 disulfiram 3.38 µM 1.05720183741353 0.141144656477073 no 468 0.145209740722246 183 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1581 himbacine 57.9 µM 1.05587566018748 0.141437434288143 no 469 0.145512512777017 165 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1502 4534-4282 27.7 µM 1.05447148057102 0.14174788084423 no 470 0.145833555546543 165 3278949 SGTC_3227 9130768 49.47 µM 1.05072719193911 0.142577950994323 no 471 0.14669195175559 160 17720899 SGTC_1341 1486-1360 280 µM 1.04702341365733 0.143402268249592 no 472 0.147544389823124 185 3976547 SGTC_1979 st071809 45.3 µM 1.04515798064298 0.14381865731767 no 473 0.14797498013758 171 4976333 SGTC_792 4534-1957 155 µM 1.04320320004014 0.144255864349389 no 474 0.148427095860427 159 1717904 SGTC_3049 9092223 49.47 µM 1.04228106355344 0.144462420470153 no 475 0.148640694585664 147 8623917 SGTC_151 3013-0144 2.285 µM 1.04204257401346 0.144515873913964 no 476 0.148695970445962 203 906558 YHR107C CDC12 SGTC_2827 7993847 71.43 µM 1.03986977806259 0.145003483552309 no 477 0.149200202545403 153 2985692 SGTC_326 k292-0812 17.5 µM 1.03905177298683 0.145187343404335 no 478 0.149390329239083 168 3579357 SGTC_1753 st043925 64 µM 1.03886406811786 0.145229555224599 no 479 0.149433979775444 158 670181 SGTC_673 1082-0474 110 µM 1.03864629014018 0.145278540353011 no 480 0.149484634443968 201 3098046 SGTC_3356 9151811 4.48 µM 1.03858827989546 0.145291590559401 no 481 0.149498129429339 198 1859254 YPR165W RHO1 SGTC_89 0302-0250 142.109 µM 1.03792694168481 0.145440423479266 no 482 0.149652034718713 193 4203518 YLR208W SEC13 SGTC_2182 6325192 200 µM 1.03390203122061 0.146348432665257 no 483 0.150590982671392 170 736248 SGTC_2350 9023895 38.85 µM 1.03364214105135 0.146407193739606 no 484 0.150651745499353 170 2997209 SGTC_2804 7954240 19.48 µM 1.03171548768447 0.146843303309587 no 485 0.151102709935219 170 828705 SGTC_3098 9119039 49.47 µM 1.03139166859108 0.146916687158851 no 486 0.151178593117377 169 17161528 SGTC_985 1493-0307 8.71 µM 1.03113525489747 0.146974813050409 no 487 0.151238698622339 185 3278274 SGTC_864 0469-0573 172 µM 1.03024948332101 0.147175725429471 no 488 0.151446453142658 184 689425 SGTC_3074 9116018 49.47 µM 1.03016573154884 0.147194731687174 no 489 0.151466106632846 195 17027303 SGTC_1600 coumarin 106 71.1 µM 1.02681302683757 0.147956931084583 no 490 0.152254257059076 182 100336 A hepatotoxic, DNA x-linker. SGTC_1498 4478-3555 97.6 µM 1.02187529724426 0.149084270587686 no 491 0.153419962770807 152 3437919 SGTC_3212 9128307 49.47 µM 1.02114299994553 0.149251949601657 no 492 0.15359334656047 147 27243542 SGTC_3045 9092950 49.47 µM 1.02110023791465 0.149261745000063 no 493 0.153603475203628 169 44120432 SGTC_225 nsc-122657 1.016 µM 1.01960845785961 0.149603732265221 no 494 0.153957096065202 167 275685 SGTC_2214 7179297 48.276 µM 1.01870439245853 0.149811241502672 no 495 0.154171663326724 162 769744 SGTC_21 0849-0113 22.993 µM 1.01800999771897 0.149970755541088 no 496 0.154336602435314 184 1560156 SGTC_1062 mesoridazine 14.2 µM 1.01574115046176 0.150492736863387 no 497 0.154876333330336 161 4078 A neuroleptic. SGTC_122 0236-0016 402.397 µM 1.01226588932855 0.151294615212511 no 498 0.155705469843135 196 6808838 SGTC_1088 bifonazole 369 nM 1.01220868920071 0.151307837242392 no 499 0.1557191412346 176 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2272 7805186 180 µM 1.0075756899865 0.15238132507743 no 500 0.156829102150833 205 2956062 YPR165W RHO1 SGTC_2463 5473429 200 µM 1.00643224899557 0.152647041627493 no 501 0.157103843574704 175 5399405 SGTC_553 k007-0256 45.7 µM 1.00570680457793 0.15281578204407 no 502 0.157278314476805 184 6287000 SGTC_237 nikkomycin 200 µM 1.00244169216373 0.15357678722527 no 503 0.158065157206697 179 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1766 st045414 44.774 µM 1.00043211946836 0.154046407146519 no 504 0.158550716261882 179 253960 SGTC_2016 5121758 140 µM 0.999286765783648 0.154314491108723 no 505 0.158827897277157 212 2795203 SGTC_3090 9117696 49.47 µM 0.998693660014457 0.154453435896592 no 506 0.158971556428612 166 7923821 SGTC_2388 9080168 200 µM 0.9984793411259 0.154503663959435 no 507 0.159023488627826 204 15943073 SGTC_877 0771-0151 33.1 µM 0.997125403819698 0.154821224059164 no 508 0.159351821789258 178 6166523 SGTC_3295 9122362 53.5725 µM 0.995406883568384 0.15522491603747 no 509 0.15976920602737 204 4730473 SGTC_1198 1612-1005 86.7 µM 0.991122798160045 0.156234298964363 no 510 0.160812810983619 218 6998509 SGTC_1304 1165-0502 251 µM 0.990016761456184 0.156495595469577 no 511 0.161082963206659 186 767425 SGTC_1496 4469-0713 57.4 µM 0.987899583870025 0.156996571881047 no 512 0.161600914641346 179 746691 SGTC_999 SEC7.066 22.7 µM 0.987622660280355 0.157062176760911 no 513 0.161668742097307 204 740511 YDR170C SEC7 SGTC_2528 xanthyletin 44.79 µM 0.985504399272306 0.157564602056393 no 514 0.162188185788613 189 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2493 resveratrol 26.09 µM 0.982120218458647 0.158369476816376 no 515 0.16302031295484 150 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1965 Pectolinarigenin 58.4 µM 0.982014346235001 0.158394700313466 no 516 0.163046390284016 172 5320438 An anti-inflammatory. SGTC_1996 st072960 66.8 µM 0.980745335517143 0.158697240502594 no 517 0.16335917063241 187 1719405 SGTC_2399 5884133 200 µM 0.980360354934195 0.158789097163529 no 518 0.163454136014347 190 722445 SGTC_923 1900-2434 73.3 µM 0.978834951077852 0.159153402251021 no 519 0.163830768608071 211 5910570 SGTC_642 0335-0876 158 µM 0.977191632810392 0.159546480410907 no 520 0.16423714478417 207 6812350 SGTC_1552 6-methylflavone 10.6 µM 0.975290909914821 0.160001921055352 no 521 0.164707989106678 182 689013 SGTC_1956 st077085 54 µM 0.975172367665015 0.160030353627532 no 522 0.164737383164164 214 24208685 SGTC_1746 st038117 42 µM 0.974515861507338 0.16018787762418 no 523 0.164900233731463 191 2898218 SGTC_2442 5158906 48.48 µM 0.974323828106129 0.160233973831278 no 524 0.164947888551083 193 1893835 SGTC_2543 pimpinellin 60.67 µM 0.972490838395003 0.16067440586312 no 525 0.165403210239171 185 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_700 3453-2283 142 µM 0.970631109436799 0.161122070056353 no 526 0.16586600428532 186 565664 SGTC_325 2810-4341 181 µM 0.965538671323868 0.162352056297047 no 527 0.167137538148368 176 774970 SGTC_236 1509-0011 5.31 µM 0.964141885675995 0.162690489885678 no 528 0.167487397768853 230 3107280 SGTC_936 3005-4620 401 µM 0.963051284004058 0.162955055563427 no 529 0.167760893794316 191 777207 SGTC_32 0928-0142 34.1 µM 0.962892769688399 0.162993532328619 no 530 0.167800669201579 197 2244242 SGTC_443 clozapine 122 µM 0.961355869515179 0.163366895987669 no 531 0.168186632641063 190 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_357 1325-0123 420 µM 0.960818146830809 0.163497657625671 no 532 0.168321806300495 203 1098503 SGTC_417 st075190 100 µM 0.957229826974088 0.16437199315819 no 533 0.169225632681422 206 222757 SGTC_2098 5376439 882.5 nM 0.956695554477443 0.164502433607337 no 534 0.169360471303615 188 2844116 SGTC_1348 1493-0373 93.8 µM 0.955539438896495 0.164784924105638 no 535 0.169652485423255 215 3010129 SGTC_1081 sertraline 6 µM 0.955285767886353 0.1648469492388 no 536 0.169716601365182 207 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_282 k297-0036 65.7 µM 0.954815744436926 0.164961914696604 no 537 0.169835441962691 201 5061378 SGTC_2019 4016004 108 µM 0.95423009648686 0.165105233975856 no 538 0.169983591670821 203 45595336 SGTC_982 1491-0518 27.5 µM 0.946608245826453 0.166977794536515 no 539 0.171919220289579 184 3091256 SGTC_1519 esterone 74 µM 0.945921682919291 0.167147141377239 no 540 0.17209426661034 196 698 A steroid. SGTC_260 nsc-65238 3.989 µM 0.945153437510658 0.167336767157854 no 541 0.172290273547034 183 3246252 SGTC_2295 7971645 200 µM 0.944683558559035 0.167452815540005 no 542 0.172410226678292 184 2978226 YKL099C UTP11 SGTC_2200 6600604 21.907 µM 0.943798174339924 0.167671624232694 no 543 0.17263639686468 221 2904777 SGTC_393 acivicin 6.25 µM 0.943676649661364 0.167701671498189 no 544 0.172667454934532 199 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3236 9132701 49.47 µM 0.942336983290574 0.168033136982274 no 545 0.173010069608262 202 24282524 SGTC_1196 1588-0294 184 µM 0.940721241106303 0.168433470734594 no 546 0.173423865404694 195 6144269 SGTC_1919 st067113 52.3 µM 0.940718745501434 0.16843408954664 no 547 0.173424505022503 210 1268243 SGTC_1763 st044482 94.5 µM 0.940210333321599 0.16856018629605 no 548 0.173554841212189 217 88505 SGTC_619 1652-1634 108 µM 0.940136705491799 0.168578452552131 no 549 0.173573721556927 190 5400454 SGTC_3095 9117207 49.47 µM 0.936745185775523 0.169421230466129 no 550 0.174444823576459 159 17015229 SGTC_2400 5203494 178.7 µM 0.936041132028014 0.169596523103541 no 551 0.174626005221061 217 6777674 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.934226537461261 0.170048850164203 no 552 0.175093524762478 201 688664 SGTC_1792 st045773 43.6 µM 0.934182844310347 0.17005975115461 no 553 0.175104791824734 132 2919270 SGTC_814 3342-0569 96 µM 0.934177038871518 0.170061199585416 no 554 0.175106288895824 203 4346283 SGTC_431 k089-0097 107 µM 0.933875814426883 0.170136364574235 no 555 0.175183977954586 213 5499420 SGTC_2191 5911152 200 µM 0.93265374359021 0.170441528099139 no 556 0.175499387516473 191 2875902 SGTC_337 1315-0038 354 µM 0.930890886362602 0.170882348623346 no 557 0.175955004643326 192 1626437 SGTC_3192 9110362 49.47 µM 0.927693647042701 0.171683710634629 no 558 0.176783252417773 205 16649480 SGTC_1540 guanosine 70.6 µM 0.92683112395128 0.171900305537853 no 559 0.177007111245067 191 6802 Guanosine is a purine nucleoside SGTC_1871 st057448 67.3 µM 0.924125884911586 0.172580770448604 no 560 0.177710388884417 208 691747 SGTC_2080 5212524 12.4 µM 0.923169809637294 0.172821667973716 no 561 0.177959359638744 215 260183 SGTC_77 0828-0286 12.516 µM 0.923074784950858 0.172845622573622 no 562 0.177984116948619 167 745345 SGTC_1707 st032323 6.317 µM 0.922455743669798 0.173001727351045 no 563 0.17814545236966 208 3132057 YMR211W DML1 SGTC_2512 diallyl trisulfide 49.23 µM 0.922265421045671 0.173049739403937 no 564 0.1781950730455 244 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2029 5175081 200 µM 0.922168508254717 0.173074190531296 no 565 0.178220343373814 195 1380876 SGTC_1852 st056254 31.4 µM 0.920152042698295 0.173583444630915 no 566 0.178746655718595 204 442583 SGTC_1929 genistein trimethyl ether 50.5 µM 0.917223509461176 0.174324735560749 no 567 0.179512764959016 195 136420 SGTC_489 paxilline 115 µM 0.917172480355771 0.174337670210443 no 568 0.179526132528021 204 105008 A toxic potassium channel blocker. SGTC_695 3505-6186 243 µM 0.916266605041844 0.174567389279031 no 569 0.179763539482318 222 1819379 SGTC_3026 9090633 49.47 µM 0.914088947685363 0.175120402997752 no 570 0.180335054765088 205 25236842 SGTC_829 1635-0120 117 µM 0.913913144687171 0.175165096404086 no 571 0.180381243066509 234 285054 SGTC_2352 9027995 87.8 µM 0.911593589229554 0.175755461244766 no 572 0.180991349185832 189 2997347 SGTC_1436 4092-1007 8.32 µM 0.91021439305316 0.176107086093143 no 573 0.181354727522158 180 2881121 SGTC_955 1216-0110 33 µM 0.906600945915903 0.177030441237942 no 574 0.182308930683436 194 3619719 SGTC_1274 0865-0114 173 µM 0.906071019771676 0.177166111610397 no 575 0.182449131619909 202 870624 SGTC_3137 9097352 49.47 µM 0.90553038546934 0.177304591117625 no 576 0.182592234969316 222 44120435 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.90341050611197 0.177848241848448 no 577 0.183154033049958 206 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2488 5268135 45.7 µM 0.903085870481316 0.177931588569153 no 578 0.183240161194332 212 1270356 YLR208W SEC13 SGTC_2841 9004761 38.96 µM 0.902827890693847 0.177997839678322 no 579 0.183308623077541 186 2991039 SGTC_545 4218-0007 221 µM 0.901926362517547 0.178229480884967 no 580 0.183547993088617 217 2840508 SGTC_3123 9126162 49.47 µM 0.900817700867047 0.178514603905893 no 581 0.183842627273031 203 25239884 SGTC_1690 st023502 41.2 µM 0.896603197510786 0.179601100019787 no 582 0.184965345626019 205 24207482 SGTC_1955 wogonin 32.4 µM 0.894725810600363 0.180086424181779 no 583 0.185466838868919 184 5281703 A flavanone. SGTC_764 1951-2361 146 µM 0.894530655476588 0.180136921022266 no 584 0.185519017673903 214 5438930 SGTC_1622 st003707 19.4 µM 0.893642888094694 0.180366745057565 no 585 0.185756495827364 184 10140899 SGTC_682 0kpi-0099 17 µM 0.892830968824648 0.180577094627507 no 586 0.185973849590316 241 1714895 YML126C ERG13 SGTC_2234 tolnaftate 200 µM 0.892722017180842 0.180605333190676 no 587 0.18600302833967 207 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2772 vinpocetine 57.06 µM 0.892660788259266 0.180621203985544 no 588 0.186019427533045 213 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3240 9133527 49.47 µM 0.890909347584226 0.181075555067799 no 589 0.18648890256073 214 17617455 SGTC_1250 0485-0349 40.2 µM 0.888022264062148 0.181826071061048 no 590 0.187264387680136 201 6842794 YDL195W SEC31 SGTC_2849 9019321 12.99 µM 0.887807183340693 0.181882060452813 no 591 0.187322239134547 211 16489627 SGTC_2155 5570423 76 µM 0.887778583509844 0.181889506316881 no 592 0.187329932621867 212 797402 SGTC_234 nsc-17383 10.7 µM 0.887348467838786 0.182001508391185 no 593 0.187445659293776 203 408974 SGTC_1421 4029-0249 71.4 µM 0.886512906025319 0.18221921182506 no 594 0.187670601333542 227 2894095 SGTC_3042 9091578 49.47 µM 0.885460070057027 0.182493757099909 no 595 0.187954273195005 198 25236497 SGTC_450 aminopyrene 156 nM 0.885212596804802 0.182558327536022 no 596 0.188020989792431 218 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_112 phenothiazine 287.218 µM 0.882848562034602 0.183175867759071 no 597 0.188659049248203 211 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1319 1306-0155 43.7 µM 0.882680430234951 0.183219837222458 no 598 0.188704479266489 221 3122360 SGTC_1312 1218-2183 165 µM 0.881867690917583 0.183432475848751 no 599 0.188924180395225 217 6744073 SGTC_2144 5628481 200 µM 0.881543216692839 0.183517411646671 no 600 0.189011936840887 200 2818399 SGTC_1330 1469-0054 61.8 µM 0.880517263138675 0.183786131004099 no 601 0.189289578717892 216 7102664 SGTC_252 miconazole 1.30953 nM 0.875956204362909 0.184983735258859 no 602 0.19052692151227 218 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_349 k015-0014 24 µM 0.875727519750062 0.185043908709468 no 603 0.190589090469822 207 2196908 SGTC_1857 st056007 79.3 µM 0.875623671273961 0.185071238222899 no 604 0.190617326263955 202 619834 SGTC_3225 9130819 49.47 µM 0.875337340418107 0.185146604101545 no 605 0.190695191250784 234 4547121 SGTC_1808 st050063 61.5 µM 0.874059548169372 0.185483167377839 no 606 0.1910429127357 221 4011993 SGTC_296 1222-0039 74.9 µM 0.872235048810102 0.185964387946466 no 607 0.19154008135167 195 5984176 SGTC_2600 tangeritin 87.95 µM 0.871981726818894 0.186031264001102 no 608 0.191609173169843 224 68077 A bioactive flavone. SGTC_668 1682-0499 62.6 µM 0.871928045972436 0.186045437457292 no 609 0.191623816208799 216 682214 SGTC_1002 4049-0206 172 µM 0.871796738908903 0.186080109532854 no 610 0.191659636983632 217 4662749 SGTC_2333 9017922 200 µM 0.868744732809182 0.186887130289719 no 611 0.192493384140176 206 3163164 SGTC_555 4296-0685 37 µM 0.867188684513132 0.187299417666411 no 612 0.192919317576411 235 2908540 YHR072W ERG7 SGTC_2173 5763948 167 µM 0.863972793905363 0.188153273770684 no 613 0.193801418050229 227 2867177 SGTC_2189 6047310 154.431 µM 0.863681776072968 0.18823066071647 no 614 0.193881363715656 212 711535 SGTC_187 1488-2104 32.728 µM 0.862264083336521 0.188607931857043 no 615 0.19427110623035 213 2852859 SGTC_453 enantio-paf c16 10 µM 0.861679532829567 0.188763625919536 no 616 0.194431945726897 246 13871343 A lipid and platelet activating factor SGTC_2682 pyrogallin 40.03 µM 0.860938329555034 0.188961158048294 no 617 0.194636004863204 211 822798 An ATP competetive kinase inhibitor. SGTC_2485 5633444 17.78 µM 0.860556646702299 0.189062926931764 no 618 0.194741135988291 228 5724239 SGTC_781 4335-2806 94.4 µM 0.855875513410639 0.190313811491472 no 619 0.19603332028947 219 845254 SGTC_1053 3366-3204 134 µM 0.854376004307202 0.1907155803944 no 620 0.196448343513024 238 3632071 YPR165W RHO1 SGTC_590 k048-0076 22.4 µM 0.853492737637581 0.190952480656552 no 621 0.196693056651733 225 6832814 SGTC_1402 3909-7673 35.9 µM 0.852151141670037 0.191312654183741 no 622 0.19706510507682 223 5328014 SGTC_2766 oltipraz 83.91 µM 0.851593142057639 0.191462580895541 no 623 0.197219973621454 229 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_624 k048-0052 28 µM 0.850670306885442 0.191710691761913 no 624 0.197476261026584 202 6835531 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.850352111707087 0.191796286450335 no 625 0.197564676038207 212 17037758 SGTC_3057 9095946 49.47 µM 0.850110635539731 0.191861259293934 no 626 0.197631789560899 251 24540043 SGTC_1695 st026914 34.495 µM 0.849607593283498 0.191996653746121 no 627 0.197771644450425 213 3289191 SGTC_1101 ebselen 5.29 µM 0.849576283622016 0.192005082713225 no 628 0.197780351081773 239 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_22 0964-0034 14.468 µM 0.84696487913672 0.192708903628703 no 629 0.198507348822636 251 138402 SGTC_890 0929-0006 47.2 µM 0.845773785505862 0.193030447820665 no 630 0.198839476049275 205 1378169 SGTC_130 0136-0219 337.655 µM 0.845266050042176 0.193167614150049 no 631 0.198981155918327 262 234244 SGTC_1811 st050069 61.5 µM 0.844690350204994 0.193323213226652 no 632 0.199141874322685 227 3877702 SGTC_1097 itavastatin 7.23 µM 0.843778998966005 0.1935696878561 no 633 0.199396456515062 231 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_345 1362-0200 395 µM 0.842973731823925 0.193787631489122 no 634 0.199621567531751 231 1419823 SGTC_429 1112-0049 25.5 µM 0.842122673615652 0.194018130883544 no 635 0.199859645507015 217 2836170 SGTC_2938 9059746 27.26 µM 0.839381794623427 0.194761601219872 no 636 0.200627548307653 210 6471769 SGTC_2348 9022543 33.42 µM 0.838313820552817 0.195051760442697 no 637 0.200927237937317 242 3162678 YDL140C RPO21 SGTC_826 1683-5028 118 µM 0.838137412922189 0.195099714130749 no 638 0.200976766413188 216 722377 SGTC_2741 miltefosine 3.04 µM 0.835437597015984 0.19583451113324 no 639 0.201735684294511 203 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2364 9055074 200 µM 0.833837138416924 0.196270892697682 no 640 0.202186382144 206 6470630 SGTC_2671 danthron 100 µM 0.833587799062203 0.196338930685523 no 641 0.202256651659103 228 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1650 st011916 45.8 µM 0.831701954556479 0.196853989664443 no 642 0.202788598568029 236 242528 SGTC_3275 9138069 49.47 µM 0.830005433224733 0.197318039313447 no 643 0.20326785588888 244 17617007 SGTC_435 c-PAF 6.7 µM 0.829487348171615 0.197459882946643 no 644 0.203414346501813 223 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3036 9090181 49.47 µM 0.828104711846302 0.197838728996085 no 645 0.203805600651698 240 25236586 SGTC_2188 6126565 140.678 µM 0.826719841557057 0.19821862702335 no 646 0.2041979362784 218 874518 SGTC_2429 5902844 64.44 µM 0.826444795354466 0.198294130159694 no 647 0.204275910742845 229 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2904 7225135 42.03 µM 0.826083654703177 0.198393293500695 no 648 0.204378319546131 266 4446116 SGTC_1091 telmisartan 47.6 µM 0.823177173577604 0.199192454847073 no 649 0.205203623780638 241 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_552 k242-0005 476 µM 0.819719875844176 0.200145588662381 no 650 0.206187908325107 256 4088318 SGTC_579 4491-1009 110 µM 0.817595434925646 0.200732627838926 no 651 0.206794117546311 271 1271041 SGTC_1463 k081-0032 34.1 µM 0.817489803682985 0.200761843489785 no 652 0.206824286931825 219 977755 SGTC_2266 7929956 200 µM 0.817361718260181 0.200797272975619 no 653 0.206860872960458 236 2967153 SGTC_2013 4024628 200 µM 0.814867737740516 0.201487876191588 no 654 0.207574011046657 242 5230760 SGTC_752 1896-0090 130 µM 0.813176191494054 0.201957087922012 no 655 0.208058523859019 242 772567 SGTC_3018 9082602 49.47 µM 0.813100779912189 0.201978021278741 no 656 0.20808013967433 241 17332089 SGTC_43 0570-0105 72.5 µM 0.812007368647421 0.202281685128458 no 657 0.208393701664708 239 1114046 YDL195W SEC31 SGTC_1313 1220-0047 237 µM 0.810200893641443 0.202783980001236 no 658 0.208912361984652 233 3528706 SGTC_1952 st077036 64.1 µM 0.810027925378959 0.202832113318093 no 659 0.208962063077012 218 2937007 SGTC_1722 st034304 3.6505 µM 0.809570349557701 0.202959479653742 no 660 0.209093577528494 228 4036148 YLR033W RSC58 SGTC_102 gallobenzophenone 83.616 µM 0.809563625169737 0.202961351744746 no 661 0.209095510586147 231 70837 SGTC_2040 5100729 123 µM 0.809368312704862 0.203015731856186 no 662 0.209151661589428 236 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2683 piperine 63.03 µM 0.808949543575688 0.203132357484749 no 663 0.209272084781859 240 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3141 9094609 49.47 µM 0.808051861840439 0.203382493199162 no 664 0.209530363770607 257 25236309 YDL196W YDL196W SGTC_2610 ononetin 44.17 µM 0.807803194136961 0.203451816032103 no 665 0.209601943040232 233 259632 SGTC_18 0111-0177 500 nM 0.807747349553391 0.20346738615483 no 666 0.209618019941869 236 721752 SGTC_1689 st020265 53.493 µM 0.804653132533378 0.204331200380656 no 667 0.210509936054226 230 5758320 YPR016C TIF6 SGTC_3310 9130229 44.1445 µM 0.804329149452636 0.204421773012847 no 668 0.210603453664317 221 7761258 SGTC_1843 st055809 45.5 µM 0.803384604262565 0.2046859661987 no 669 0.21087623541999 234 16413835 SGTC_1631 benzylvanillin 81.9 µM 0.803320976390607 0.204703770476088 no 670 0.210894618399806 219 75506 SGTC_661 1304-0007 33.6 µM 0.802161669275917 0.205028327725886 no 671 0.211229722899278 236 3117130 SGTC_2265 7929201 200 µM 0.802104883769502 0.205044233134384 no 672 0.21124614509298 260 1265108 SGTC_2862 9027634 71.43 µM 0.79960028773599 0.205746490433836 no 673 0.2119712103623 235 5012562 SGTC_812 4251-0442 148 µM 0.799575316809456 0.205753499146676 no 674 0.211978446613987 251 5723007 SGTC_971 1315-0384 26.7 µM 0.798938243423772 0.205932357581001 no 675 0.212163111104632 236 6769120 SGTC_218 alverine citrate 93.75 µM 0.798738892873645 0.205988344212611 no 676 0.212220914919267 241 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1659 st012954 42.1 µM 0.79661942326918 0.206584144946764 no 677 0.212836046703957 237 24207262 SGTC_1868 st057644 42.7 µM 0.796140485627772 0.20671891959237 no 678 0.212975192371365 232 688665 SGTC_2961 9083290 32.55 µM 0.794962315113631 0.207050682172855 no 679 0.21331771185165 244 17741490 SGTC_2970 9090938 41.86 µM 0.794756927330275 0.207108549816399 no 680 0.213377455350307 233 17217104 SGTC_2508 celastrol 40.54 µM 0.794557303704478 0.207164802586287 no 681 0.213435531508596 211 122724 Celastrol is a natural product and antioxidant. SGTC_175 3793-3120 23.7 µM 0.793197086743358 0.20754834429175 no 682 0.213831502293874 261 5322297 SGTC_1723 st034307 2.5525 µM 0.792543414547184 0.207732810067924 no 683 0.214021943942213 260 867466 SGTC_934 2950-0684 338 µM 0.792141640361244 0.207846238466448 no 684 0.214139046290977 241 1121253 SGTC_3124 9127567 49.47 µM 0.791910303622972 0.207911565762435 no 685 0.214206489323997 204 17592030 SGTC_426 0988-0037 14.6 µM 0.791703870389319 0.20796987078065 no 686 0.214266682516888 253 5383008 SGTC_2950 9072895 21.46 µM 0.790840105406518 0.208213937305787 no 687 0.21451865162595 235 17332245 SGTC_2700 st077718 96.8 µM 0.790611920602844 0.208278441702505 no 688 0.214585244228279 229 904970 SGTC_2754 granisetron 64.02 µM 0.786555970536411 0.209426963423915 no 689 0.215770921137817 255 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.786202116243511 0.209527340629085 no 690 0.215874543244423 242 676296 Flavone; oxidizing agent. SGTC_2118 5526350 200 µM 0.784872298165188 0.209904820656345 no 691 0.216264222708915 240 743594 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.784068348548261 0.210133222237214 no 692 0.216500003191596 260 442882 SGTC_2261 9010538 184.68 µM 0.783978809455254 0.210158669269372 no 693 0.216526272211744 279 6457250 SGTC_1757 st041620 31.8375 µM 0.782492766774676 0.210581267211234 no 694 0.216962517305911 242 5289815 SGTC_2111 5486399 200 µM 0.78189734006401 0.210750733337736 no 695 0.217137454185282 231 689674 SGTC_2123 5259487 200 µM 0.78117416278901 0.210956666467997 no 696 0.21735003384315 224 2173474 SGTC_3201 9113999 49.47 µM 0.781035315341777 0.21099621838727 no 697 0.217390862123548 217 16649224 SGTC_713 1488-1073 324 µM 0.780469418600634 0.211157464021199 no 698 0.217557310624459 252 3312542 SGTC_621 3584-0052 32.1 µM 0.779676839638873 0.211383421444978 no 699 0.21779055729146 249 2273927 SGTC_425 3825-7017 13.1 µM 0.779368603488824 0.211471335145471 no 700 0.217881306507884 243 3397440 SGTC_1572 epiandrosterone 68.9 µM 0.77908017307815 0.211553619331745 no 701 0.217966244372767 224 441302 A steroid. SGTC_358 0075-0058 9.45 µM 0.778323033155635 0.211769707366826 no 702 0.21818930005549 277 1069125 SGTC_2822 7994718 71.43 µM 0.77758413874819 0.211980712599383 no 703 0.218407107326074 280 1018011 SGTC_2256 7954252 200 µM 0.776706342162093 0.212231543712958 no 704 0.218666022107882 242 2972920 SGTC_962 1254-0300 21.5 µM 0.773995398482848 0.213007292580063 no 705 0.219466756208752 220 7340576 SGTC_156 3474-0145 5.642 µM 0.773821377780839 0.21305714584007 no 706 0.219518214347582 236 2265471 SGTC_418 lividomycin a 100 µM 0.773063933921091 0.213274216805889 no 707 0.219742272159693 231 72394 An antibiotic. SGTC_1999 st074831 12.5 µM 0.771223542722507 0.213802179693566 no 708 0.220287220972842 246 17112523 SGTC_1675 st018485 24.5 µM 0.771136280227011 0.213827232039235 no 709 0.220313079049734 267 3323024 SGTC_1745 st081495 74 µM 0.770781857082463 0.213929001582417 no 710 0.220418121446227 240 13842402 YBL026W LSM2 SGTC_3203 9113543 49.47 µM 0.770558626287363 0.213993114847399 no 711 0.220484296353515 238 17018012 SGTC_1736 st036774 51 µM 0.769794983836584 0.214212522238407 no 712 0.220710757860783 259 1272247 SGTC_173 1273-0061 2.693 µM 0.76964829378853 0.214254683750307 no 713 0.220754274684258 245 2847414 YPL266W DIM1 SGTC_789 1309-1135 70.6 µM 0.768267750187188 0.214651714697718 no 714 0.221164065092325 232 3092424 SGTC_40 0327-0103 19.753 µM 0.768177569049417 0.214677664787801 no 715 0.221190848932547 233 409036 SGTC_1228 0124-0032 52.5 µM 0.766980182817138 0.215022391659821 no 716 0.22154664904713 249 X1228 SGTC_1453 4237-0541 195 µM 0.766498368909094 0.215161196275975 no 717 0.221689911009756 240 739892 SGTC_2094 5332512 191.667 µM 0.765407963789958 0.215475520462342 no 718 0.222014326118279 255 755774 SGTC_2073 5212005 126 µM 0.764868954433803 0.215630995601199 no 719 0.222174791135903 262 691789 SGTC_2247 cerulenin 830 nM 0.764211430571089 0.215820743829253 no 720 0.22237062793659 233 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1883 5-benzylidenerhodanine 20 µM 0.762365599488515 0.216353930591365 no 721 0.222920915858298 238 1273210 SGTC_482 fipronil 114 µM 0.761164692335968 0.216701233642416 no 722 0.223279352131055 245 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_17 0960-0276 49.807 µM 0.756795621235038 0.217967488714131 no 723 0.224586158290612 248 6821114 SGTC_1790 st045711 43.5 µM 0.754951147557576 0.218503336742551 no 724 0.225139147432011 208 585119 SGTC_3189 9110682 49.47 µM 0.754850130825409 0.218532705553322 no 725 0.225169455384826 245 17122418 SGTC_2921 7974240 10.71 µM 0.753675160756958 0.218874474046743 no 726 0.225522150266457 255 2979074 YDR527W RBA50 SGTC_1954 st077032 68.9 µM 0.751919536495595 0.219385712440642 no 727 0.226049724332066 282 698907 SGTC_1054 3429-0080 167 µM 0.751469851118544 0.219516771277277 no 728 0.226184969228529 259 1162877 SGTC_186 3455-3465 67.277 µM 0.750892852940945 0.219685000729345 no 729 0.226358570974051 254 755278 SGTC_2587 piperic acid 92.2 µM 0.750533527064892 0.21978980309048 no 730 0.226466719554561 243 5370536 SGTC_1958 st076513 41.9 µM 0.749205323277399 0.220177441112806 no 731 0.226866730587838 264 732122 YGL099W LSG1 SGTC_1654 st012436 41.8 µM 0.747711377604669 0.220613919281499 no 732 0.227317133470089 254 4323132 SGTC_2199 6590217 200 µM 0.746549990580267 0.220953577753478 no 733 0.227667622564954 231 703109 SGTC_2380 9035439 200 µM 0.746539441645587 0.220956664259023 no 734 0.227670807467965 241 6462575 SGTC_2332 7982454 138.89 µM 0.744313983298914 0.221608361172447 no 735 0.228343271788538 282 2981748 SGTC_1841 st054148 70 µM 0.74373709610567 0.221777474292085 no 736 0.228517771170608 258 675442 SGTC_849 0386-0493 241 µM 0.742728837516661 0.222073219870297 no 737 0.228822933474447 264 726119 SGTC_1513 0337-0559 19 µM 0.742583862084317 0.222115763024884 no 738 0.228866830937774 254 775073 SGTC_3194 9111903 49.47 µM 0.742519259109564 0.222134722316863 no 739 0.228886393751693 251 17087251 SGTC_2087 5276107 200 µM 0.741280018426319 0.222498585963344 no 740 0.229261837261455 259 144405 SGTC_433 pimozide 108 µM 0.740409757360268 0.222754313488495 no 741 0.229525700021893 246 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.740387475555654 0.222760863228804 no 742 0.229532458088336 255 6710655 SGTC_1791 st048313 56.1 µM 0.738619153160914 0.223281011759623 no 743 0.230069145276999 232 1204976 SGTC_3344 9148862 3.898 µM 0.735911655620317 0.224078754679636 no 744 0.230892231745062 270 4905352 SGTC_2962 9082311 13.18 µM 0.73550047856553 0.224200046219806 no 745 0.231017374317514 269 16459453 SGTC_2316 5844804 197.44 µM 0.734300737461163 0.224554166252922 no 746 0.231382734275368 255 776813 SGTC_981 1488-1094 54.9 µM 0.733771945351223 0.224710347194233 no 747 0.23154387082726 256 3449522 SGTC_3148 9097893 49.47 µM 0.733711587499148 0.224728178052412 no 748 0.231562267393408 229 17174100 SGTC_344 k064-0035 6.43 µM 0.732101052475066 0.225204257006363 no 749 0.232053445741235 246 5088750 SGTC_1692 fluoroquinolonic acid 71 µM 0.730386639398638 0.225711669778949 no 750 0.232576941380462 263 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_660 4031-1742 102 µM 0.728941477753338 0.226139894445982 no 751 0.233018730678199 255 6738706 SGTC_2085 5307070 144.047 µM 0.728582090475939 0.226246457924216 no 752 0.233128668524166 278 2840351 SGTC_1908 st060353 56.5 µM 0.726848956918578 0.226760754974801 no 753 0.233659244317892 284 4227716 SGTC_2149 5554786 194.827 µM 0.726418882823336 0.22688847897751 no 754 0.233791009385334 254 745063 YPR165W RHO1 SGTC_105 0111-0055 734.78 µM 0.724781751141964 0.227375047680751 no 755 0.234292966415483 249 5179370 SGTC_372 0155-0182 15.9 µM 0.723048708363359 0.227890761844782 no 756 0.23482497985508 238 771486 SGTC_1494 4358-1428 177 µM 0.720920754632882 0.228524891733732 no 757 0.235479136281666 249 1564571 SGTC_2975 9084847 53.72 µM 0.719783127637754 0.228864310593636 no 758 0.235829267421647 249 27211724 SGTC_1951 sophoraflavanone G 9.2 µM 0.719592504544866 0.228921211972747 no 759 0.235887964170092 251 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_365 0121-0052 13.6 µM 0.718981519678727 0.229103645684948 no 760 0.236076153164309 228 3101739 SGTC_292 k038-0015 474 µM 0.716330716934335 0.229896091459543 no 761 0.23689358209843 270 46368540 SGTC_56 0957-0365 83.25 µM 0.716234740415565 0.229924811970157 no 762 0.236923207571215 245 6752360 SGTC_1027 k015-0025 8.67 µM 0.714695877882238 0.230385583330479 no 763 0.237398492712852 266 3598955 SGTC_773 4358-1457 44.6 µM 0.71400421557317 0.230592851217627 no 764 0.237612286364721 272 1186886 SGTC_1441 4106-0040 13 µM 0.713870518207798 0.230632927826902 no 765 0.237653624562694 256 2904180 SGTC_3110 9122132 49.47 µM 0.713266832145801 0.230813934895526 no 766 0.237840328778353 246 918317 SGTC_2852 9023854 51.95 µM 0.711609332391087 0.231311321422375 no 767 0.238353363216582 285 19798528 SGTC_333 3486-0131 40.1 µM 0.708626843148436 0.232207817868226 no 768 0.239278036974273 254 6744690 SGTC_1068 loratadine 26.9 µM 0.708070534067046 0.232375250658498 no 769 0.239450728440422 276 3957 A H1 histamine antagonist. SGTC_1720 st037298 9.481 µM 0.707470671801859 0.232555866907911 no 770 0.239637016077844 275 597396 SGTC_1018 4259-0013 28.1 µM 0.7066763482144 0.232795154787266 no 771 0.239883815487116 268 6801262 SGTC_3235 9132602 49.47 µM 0.706643296973989 0.232805114349854 no 772 0.239894087638776 267 4912240 SGTC_1168 k815-0004 80.5 µM 0.704803099242909 0.233360007473412 no 773 0.240466389789343 280 642433 SGTC_2971 9092186 9.93 µM 0.704331835182809 0.233502230351479 no 774 0.240613072581435 251 25236400 SGTC_1892 st058411 7.36 µM 0.704295324425301 0.233513250946768 no 775 0.240624438730989 277 3934738 SGTC_1187 1391-0724 117 µM 0.704263903983408 0.233522735285899 no 776 0.240634220450386 264 6997986 SGTC_1102 cgs 12066b 26.1 µM 0.703909023525324 0.233629871673902 no 777 0.240744715816549 261 6438352 A 5-HT1B full agonist. SGTC_2788 5282734 71.43 µM 0.70373627182141 0.233682034289485 no 778 0.240798513673489 276 743706 SGTC_492 tmb-8 126 µM 0.702383148712368 0.234090834951686 no 779 0.241220125717341 254 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2713 st079149 53.4 µM 0.701972709071659 0.234214913733438 no 780 0.241348091565997 265 3103253 SGTC_1560 lithocholic acid 53.1 µM 0.701082296169834 0.234484216929781 no 781 0.241625829037756 265 9903 A bile acid which acts as a detergent. SGTC_1131 3454-3128 32.3 µM 0.70011597336115 0.234776672626147 no 782 0.241927440554845 265 710982 SGTC_1345 1488-0192 31.4 µM 0.699268541921433 0.235033311952552 no 783 0.242192111347733 264 658348 SGTC_3103 9120822 49.47 µM 0.697806538295281 0.235476434738137 no 784 0.242649094806187 284 17141819 SGTC_2693 st077581 40.7 µM 0.695992176952259 0.236026995082362 no 785 0.243216864487916 273 25238761 SGTC_1963 st076565 50.3 µM 0.693800523642012 0.23669298790126 no 786 0.243903657097729 297 4914280 SGTC_1096 rimcazole 32.2 µM 0.693747694310132 0.236709054263536 no 787 0.243920224992522 276 18528119 A dopamine reuptake inhibitor. SGTC_1596 piperlongumine 63 µM 0.693628044869999 0.236745444055691 no 788 0.24395775069777 250 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1564 D-Arginine 115 µM 0.693428042775287 0.236806278912627 no 789 0.244020484394563 290 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_478 N-arachidonylglycine 10 µM 0.69328359655675 0.236850220623182 no 790 0.244065797557744 234 5283389 SGTC_1041 0206-0046 107 µM 0.692783554621268 0.23700237205111 no 791 0.244222697086898 278 50494 SGTC_1236 0330-0013 258 µM 0.692500220190979 0.23708860813407 no 792 0.24431162383763 279 4617066 SGTC_2581 avocatin a 64 µM 0.692430805382961 0.237109737956097 no 793 0.244333412885239 282 6710728 A skin care supplement. SGTC_627 1391-0720 175 µM 0.691636573852693 0.237351575146686 no 794 0.244582793713262 301 997839 SGTC_2624 nerol 100 µM 0.690622579717263 0.237660525047294 no 795 0.244901376955828 292 637566 A natural product oil. SGTC_1603 st002045 67.8 µM 0.690011895903382 0.237846698310069 no 796 0.245093353241048 273 5887985 SGTC_1889 st059080 5.18 µM 0.689696585920262 0.237942855111295 no 797 0.245192506651981 262 176925 Isolated from Daphnopsis sellowiana. SGTC_1555 citronellol 128 µM 0.689314797999138 0.238059313518258 no 798 0.245312593797049 269 8842 A terpine precursor. SGTC_1380 2291-0730 164 µM 0.688403945450245 0.238337280908887 no 799 0.245599219977455 265 2999191 SGTC_3230 9131665 49.47 µM 0.688102386166067 0.238429347742129 no 800 0.245694153974509 269 15943720 SGTC_2929 9013348 24.6 µM 0.685655847717127 0.239177001673346 no 801 0.246465077593285 275 2995952 SGTC_331 k048-0133 24.5 µM 0.684797022016413 0.239439759410325 no 802 0.246736007410112 265 6813582 SGTC_605 1315-0399 119 µM 0.683967249479486 0.239693777985403 no 803 0.246997923349176 288 24020461 SGTC_2880 9042983 58.44 µM 0.683218154483505 0.239923224967479 no 804 0.247234501303244 285 6464714 SGTC_3017 9080681 49.47 µM 0.68246413266306 0.240154301950705 no 805 0.247472757546694 290 16451914 SGTC_2258 7960471 200 µM 0.680694264348466 0.240697170731251 no 806 0.248032483177824 289 2974708 SGTC_2082 5219693 150 µM 0.680337478733139 0.240806687828193 no 807 0.24814539934075 273 2834649 SGTC_724 3910-0327 137 µM 0.679350138470693 0.24110989805255 no 808 0.248458017456151 296 2885483 SGTC_339 3091-4833 71.4 µM 0.676375859712187 0.242024546233668 no 809 0.249401020017944 276 3240077 SGTC_3317 9138495 8.753 µM 0.674127256193528 0.242717282397291 no 810 0.250115206182522 282 17020139 SGTC_226 1,3-diallylurea 8.28947 mM 0.673817260648677 0.242812868063486 no 811 0.250213749880882 274 74537 YKL182W FAS1 SGTC_2353 9059630 146.67 µM 0.671471540908341 0.243536819565151 no 812 0.250960091668493 276 4779114 SGTC_770 0389-1121 67.2 µM 0.669915645175856 0.244017652731337 no 813 0.251455782870353 282 6753108 SGTC_2718 lomofungin 53.02 µM 0.669483950835984 0.244151154011754 no 814 0.251593407560555 280 5351222 A RNA synthesis inhibitor. SGTC_392 N-ethylmaleimide 8.33 µM 0.669374620970345 0.244184970472729 no 815 0.251628268370868 271 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2099 5377090 177.372 µM 0.668755358538699 0.244376560152249 no 816 0.251825773908227 290 2243829 SGTC_2190 6049624 200 µM 0.668742549159439 0.244380524019915 no 817 0.251829860153582 282 2265554 SGTC_152 4469-0003 551.229 µM 0.66597891452291 0.245236541490732 no 818 0.252712288954535 279 697280 SGTC_2762 leflunomide 42.06 µM 0.665925973645902 0.245252955297709 no 819 0.252729208862261 302 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2426 5582046 32.21 µM 0.665843397810307 0.245278558316061 no 820 0.25275560129551 276 2251934 SGTC_1744 st037937 38.9 µM 0.665186034884251 0.245482427958989 no 821 0.25296575575942 281 1016152 SGTC_53 0973-0023 39.979 µM 0.664841498730577 0.245589316188776 no 822 0.25307593834287 296 674768 SGTC_1297 1068-0111 14.1 µM 0.661835237752424 0.246523032554877 no 823 0.25403841012278 285 767057 SGTC_2159 5658611 73.75 µM 0.660208761368534 0.247028992543755 no 824 0.254559935319432 290 793844 SGTC_996 3970-0799 1.8 µM 0.66004740426498 0.247079217361066 no 825 0.254611704596504 295 6615648 YGL040C HEM2 SGTC_3323 9138564 53.9225 µM 0.657540291300706 0.247860295183317 no 826 0.255416786333021 283 43912313 YNL103W MET4 SGTC_181 1447-1644 8.07 µM 0.656282869318265 0.248252534093667 no 827 0.255821068826716 298 534600 SGTC_169 k015-0017 16.025 µM 0.654466977844422 0.248819564999255 no 828 0.256405497673169 329 1840002 SGTC_2165 5727197 32.143 µM 0.654164162132151 0.248914189371958 no 829 0.256503023910457 296 1361712 SGTC_2184 6075246 200 µM 0.653677549595281 0.249066286999965 no 830 0.256659785076628 283 2267320 SGTC_994 3910-0338 138 µM 0.653674749941923 0.249067162214234 no 831 0.256660687123155 284 3479481 SGTC_338 4055-0136 114 µM 0.653390526489534 0.249156023307321 no 832 0.256752272328344 279 2900563 SGTC_3251 9135047 49.47 µM 0.652781165233223 0.249346593984471 no 833 0.256948683874789 265 17682963 SGTC_2465 5809242 33.21 µM 0.652412467127773 0.249461937662082 no 834 0.25706756194266 318 2731748 SGTC_3341 9147222 25.867 µM 0.652394866189062 0.249467444656522 no 835 0.257073237668355 292 1939759 SGTC_486 niguldipine 82 µM 0.652193450809064 0.249530468245797 no 836 0.257138192165058 279 1236 A calcium channel blocker. SGTC_544 k015-0020 52.4 µM 0.651969821965914 0.249600452416133 no 837 0.257210320283658 285 3008304 SGTC_1147 3809-1045 12.3 µM 0.651083229989242 0.249878012068652 no 838 0.257496380665439 280 325925 SGTC_1780 st038448 24.544 µM 0.650822823766765 0.249959566887728 no 839 0.257580432555711 298 728868 YDL195W SEC31 SGTC_1225 1216-0074 20.6 µM 0.650478870472332 0.250067308882024 no 840 0.257691472953338 284 4241466 SGTC_1855 st056195 39.6 µM 0.64884735978078 0.250578708515978 no 841 0.258218521145366 278 4028379 SGTC_1337 1486-1011 40.3 µM 0.6487337921086 0.250614327098919 no 842 0.258255229183385 283 X1337 SGTC_919 tnp00227 403.569 nM 0.648172644845381 0.250790360821922 no 843 0.258436646327509 313 1269246 A methoxyflavone. YNL221C POP1 SGTC_2028 5153890 36.43 µM 0.645716769291707 0.251561546562934 no 844 0.25923139919778 291 2830968 YPR165W RHO1 SGTC_1355 1499-0035 1.68 µM 0.645620486268754 0.251591806533867 no 845 0.259262583333284 293 1548538 SGTC_906 1165-0455 526 µM 0.644875671018714 0.251825953128382 no 846 0.259503879506364 291 3252859 SGTC_1588 farnesol 29.9 µM 0.642270839305909 0.252645734504656 no 847 0.260348672301379 289 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_98 0074-0023 107.663 µM 0.641567260069858 0.252867402781182 no 848 0.260577098213715 284 3563821 SGTC_980 1473-0395 201 µM 0.641362868476241 0.252931817175166 no 849 0.260643475868916 306 768876 SGTC_1328 1441-0025 69.2 µM 0.640238730589513 0.253286245637151 no 850 0.261008703315698 292 4562601 SGTC_200 k038-0079 37.545 µM 0.639216985589779 0.25360861711505 no 851 0.261340891890313 309 3436683 SGTC_162 k030-0015 37.8 µM 0.638635408472027 0.253792207120852 no 852 0.261530070519685 315 1809920 YMR134W ERG29 SGTC_444 curcumin 90.4 µM 0.638214213735745 0.25392521179093 no 853 0.261667122959632 284 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.636702771151389 0.254402795392154 no 854 0.262159234093643 302 91467 include heat shock SGTC_1949 st076024 69.1 µM 0.63512957330293 0.254900391886097 no 855 0.262671955376503 294 2921930 SGTC_1151 3909-8316 15.3 µM 0.635108049922202 0.25490720317978 no 856 0.262678973622539 300 800431 SGTC_2960 9079389 5.97 µM 0.633970652151937 0.255267279791763 no 857 0.263049987554768 274 16457355 SGTC_278 4092-0821 23.9 µM 0.631405393313769 0.256080362818149 no 858 0.263887745239291 289 877900 SGTC_45 0kpi-0036 14.9 µM 0.630879845761722 0.25624710664363 no 859 0.264059545346253 305 2795021 SGTC_1163 k060-0048 49.9 µM 0.630583527307116 0.256341146438558 no 860 0.264156436184951 284 6809982 SGTC_2438 5259590 200 µM 0.630003517227357 0.256525270818471 no 861 0.264346141515896 287 1201127 SGTC_484 loperamide 105 µM 0.628369092541486 0.257044489794873 no 862 0.264881089675225 271 3955 An opioid-receptor agonist. SGTC_1937 st074714 47.2 µM 0.627454145274887 0.257335385876193 no 863 0.265180792493091 279 17250970 SGTC_2459 5811157 9.22 µM 0.625753542136452 0.257876525629809 no 864 0.265738304176315 303 2870684 YBR192W RIM2 SGTC_1493 4348-0038 111 µM 0.623675843843418 0.258538459270423 no 865 0.266420245148733 316 800424 SGTC_1651 st011928 86.1 µM 0.623536360451192 0.258582928765679 no 866 0.266466058003477 295 720198 SGTC_1386 3228-0095 33.8 µM 0.623352172993415 0.258641656686585 no 867 0.266526559864201 301 870181 SGTC_929 2805-0021 398 µM 0.623055477382211 0.258736272198386 no 868 0.266624032988895 329 3098024 SGTC_72 0744-0168 198.391 µM 0.621743610480228 0.259154838001224 no 869 0.267055235284967 323 677577 SGTC_1021 4476-0760 85.3 µM 0.621331977885354 0.25928624609616 no 870 0.267190608841041 291 746768 SGTC_2932 9016711 44.54 µM 0.620969895531193 0.259401864410761 no 871 0.267309715442654 307 7117328 SGTC_1626 st003712 1.76 µM 0.620480716007688 0.259558109039373 no 872 0.267470673055148 307 24207035 SGTC_496 calpeptin 138 µM 0.620439846218524 0.259571165106784 no 873 0.26748412289401 276 73364 A calpain inhibitor. SGTC_2999 9069765 71.4286 µM 0.620069956459027 0.259689343740793 no 874 0.267605865424139 274 2097066 SGTC_33 0986-0033 35.816 µM 0.619383266503382 0.259908812669992 no 875 0.267831951050842 268 2848082 SGTC_1145 3546-0597 10.2 µM 0.619004701443235 0.260029844514966 no 876 0.267956630846473 296 875334 SGTC_451 chloral hydrate 100 µM 0.61628889753569 0.260898971286024 no 877 0.268851932566972 314 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_753 1322-0200 289 µM 0.616277056347093 0.260902764038284 no 878 0.268855839462694 281 5403907 SGTC_783 0848-0141 92.7 µM 0.614729991679821 0.261398535170892 no 879 0.269366524871482 315 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1867 st057372 64 µM 0.613467977879646 0.261803317138978 no 880 0.269783475001394 283 688837 SGTC_2872 9044037 25.97 µM 0.613336062752577 0.261845646532735 no 881 0.269827076398176 301 6465195 SGTC_3107 9121808 49.47 µM 0.6123701020659 0.262155714348846 no 882 0.270146459116801 253 662681 SGTC_1149 3909-7961 23.3 µM 0.610215665046815 0.262847953362971 no 883 0.270859477052449 287 735261 SGTC_2665 lovastatin 100 µM 0.609088002780372 0.263210653184177 no 884 0.271233054646796 302 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2274 7947094 46.08 µM 0.606575068224017 0.264019828809076 no 885 0.27206647505642 299 2971028 SGTC_1824 st053723 68.6 µM 0.606310772440389 0.264105006790549 no 886 0.272154203293899 306 675225 SGTC_1063 disulfiram 1.84 µM 0.605703440968648 0.264300792303335 no 887 0.272355849332124 315 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_387 norethindrone acetate 66.7 µM 0.605576973031926 0.264341571080259 no 888 0.272397848518563 309 541197 SGTC_1860 st056228 74.6 µM 0.603709301488353 0.264944162520897 no 889 0.273018464487416 334 688679 SGTC_284 0988-0104 32.6 µM 0.603015256466424 0.265168269166212 no 890 0.273249269964607 308 4666532 SGTC_831 k061-1017 217 µM 0.60056583322367 0.265959954829544 no 891 0.27406460021153 317 1240153 SGTC_3282 9108498 15.4605 µM 0.60013937533966 0.266097913894098 no 892 0.274206676399874 304 16459645 SGTC_3307 9126885 69.2785 µM 0.599651796437583 0.266255689990216 no 893 0.274369159863002 288 24824909 SGTC_3245 9134821 49.47 µM 0.598139832477491 0.26674524866812 no 894 0.27487331701448 321 17014901 SGTC_168 3970-0862 530.542 µM 0.597539126702657 0.266939877343307 no 895 0.275073746139037 315 3135186 SGTC_1850 st056238 17 µM 0.596960950613645 0.267127274123134 no 896 0.275266726056336 310 5393177 SGTC_3276 9139060 49.47 µM 0.595237823517156 0.267686162777741 no 897 0.275842255360221 335 4870619 SGTC_827 3253-0474 693 µM 0.594433359549653 0.267947288746006 no 898 0.276111150889086 303 5402065 SGTC_2751 anetholtrithion 17.25 µM 0.590980039392301 0.269069678656124 no 899 0.27726689762698 310 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2466 5983409 37.09 µM 0.589687998447154 0.269490220435083 no 900 0.277699921417372 317 2879657 SGTC_1192 1488-0095 21.4 µM 0.589591849551509 0.269521528759373 no 901 0.277732158642116 314 915875 SGTC_409 arachidonic acid 100 µM 0.589525320813188 0.269543193136128 no 902 0.277754465759962 306 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1623 st003709 20.3 µM 0.588683773399692 0.26981730942137 no 903 0.278036712518863 295 16192618 SGTC_1462 k081-0014 26.5 µM 0.584217347531306 0.271274485471633 no 904 0.279537045841178 284 3270634 SGTC_696 1560-0013 611 µM 0.583784755221906 0.271415827238017 no 905 0.279682568031151 292 1650269 SGTC_1401 3807-4679 7.6 µM 0.583498239667384 0.271509461242624 no 906 0.279778970864423 318 3291456 SGTC_3271 9137798 49.47 µM 0.583305040660596 0.271572608245415 no 907 0.279843984921538 287 6498326 SGTC_944 3370-0224 231 µM 0.583044390316301 0.271657813273414 no 908 0.279931708868948 294 4580514 SGTC_920 mycophenolic acid 780.421 nM 0.582526935840099 0.2718270054533 no 909 0.280105901793618 295 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1902 st060212 70.5 µM 0.582259216176227 0.271914562375204 no 910 0.280196046030548 305 688944 SGTC_3128 9127691 49.47 µM 0.580592844391368 0.272459859548449 no 911 0.280757448034719 318 41316314 SGTC_3211 9128781 49.47 µM 0.580013245154877 0.272649652613045 no 912 0.280952842915142 329 17194361 SGTC_2922 7999257 32.47 µM 0.579080137914317 0.272955341669783 no 913 0.281267550653927 319 2988377 SGTC_1673 st016611 27.3 µM 0.578230672642222 0.273233777030597 no 914 0.281554196499906 336 5226799 SGTC_2946 9065502 71.43 µM 0.576221253871257 0.273892978300216 no 915 0.282232820513606 281 16489101 SGTC_2414 st077232 92.9 µM 0.575900651442265 0.273998226437299 no 916 0.282341167636074 286 729801 SGTC_1838 st055369 84.5 µM 0.575773548889713 0.274039957501293 no 917 0.282384127296442 290 676036 SGTC_853 0419-0306 21 µM 0.574909004893791 0.2743238930227 no 918 0.282676419748471 323 762713 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.574302575879885 0.274523144463501 no 919 0.282881533196009 313 15053 SGTC_2863 9028737 58.44 µM 0.574124565606207 0.274581645989636 no 920 0.282941755460105 322 6460917 SGTC_255 tunicamycin 200.472 nM 0.573099815410607 0.274918540772725 no 921 0.283288556108705 302 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2696 st077691 74.316 µM 0.572856754951004 0.274998478709345 no 922 0.283370843642611 343 757133 SGTC_1412 3909-8563 178 µM 0.572693784419587 0.27505208301243 no 923 0.283426023341224 333 23767530 SGTC_587 k089-0003 57 µM 0.571898172765198 0.275313849644961 no 924 0.28369548100895 312 9659696 SGTC_1735 st034310 56.75 µM 0.571280447284596 0.275517173919188 no 925 0.283904776783141 298 871153 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.568204959033751 0.276530568362592 no 926 0.284947902284569 327 6708784 An antioxidant flavonoid SGTC_3040 9091894 49.47 µM 0.568040144107917 0.276584927555844 no 927 0.285003854779839 296 25236966 SGTC_1206 3978-0017 132 µM 0.566935807431983 0.276949294507326 no 928 0.285378897624343 323 3873677 SGTC_1438 4092-1045 4 µM 0.566812082315929 0.276990131243583 no 929 0.285420930443873 321 1351342 SGTC_3004 9076122 71.4286 µM 0.563448147326412 0.278101560481773 no 930 0.286564879704198 336 44782551 SGTC_1742 st038235 28.8875 µM 0.561460400170177 0.278759324259816 no 931 0.287241859306793 337 564103 YBR002C RER2 SGTC_1385 3091-4834 14.1 µM 0.560885857011706 0.278949586840892 no 932 0.287437676010254 318 4072814 SGTC_656 4090-1979 187 µM 0.560707681561373 0.27900860328234 no 933 0.287498414870716 315 22330961 SGTC_2748 diazoxide 86.69 µM 0.560625270522368 0.279035902061098 no 934 0.287526510314334 284 3019 A potassium channel activatior. SGTC_1964 st076914 61 µM 0.558099046857514 0.279873346991092 no 935 0.288388375719404 345 24208661 SGTC_3159 9100096 49.47 µM 0.557560204366344 0.280052131264206 no 936 0.288572368738444 299 25236875 SGTC_1840 st055363 71 µM 0.555391392068222 0.280772287728123 no 937 0.289313489544511 312 676033 SGTC_692 k241-0027 77.8 µM 0.554432989821336 0.28109081128893 no 938 0.289641276949347 325 3600480 SGTC_1516 st013856 110 µM 0.554356860760735 0.281116120150712 no 939 0.289667321659068 316 5281404 A mutagen and neurotoxin. SGTC_2135 5326629 150.42 µM 0.553995215458798 0.281236363002188 no 940 0.289791060079523 316 5020077 SGTC_2808 7946468 45.46 µM 0.553194874972153 0.281502555151944 no 941 0.290064987985986 345 2970879 SGTC_742 0kpi-0133 140 µM 0.55052193293467 0.282392451801754 no 942 0.290980718792579 330 2728852 SGTC_1777 st045864 34.765 µM 0.55015750023639 0.282513886314379 no 943 0.291105675389742 337 4691462 SGTC_2657 nystatin 74.44 µM 0.546704381947172 0.283665762128708 no 944 0.292290921623955 312 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1356 1502-0781 85.8 µM 0.545993306079745 0.283903238665322 no 945 0.292535269285041 314 567702 SGTC_709 3807-1509 243 µM 0.545849331111231 0.283951333268592 no 946 0.292584755090886 349 1886677 YPL242C IQG1 SGTC_2540 epiandrosterone 100 µM 0.545266292677123 0.284146136158807 no 947 0.292785191673932 337 441302 A steroid. SGTC_507 nimesulide 162 µM 0.542123880809608 0.285197167535131 no 948 0.293866584235094 328 4495 A COX2 inhibitor. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.54204959677492 0.285222035452241 no 949 0.293892169804635 339 23665772 A membrane-active detergent. SGTC_1771 st048882 4.1505 µM 0.541535763608372 0.285394078635572 no 950 0.294069177009808 308 4580403 SGTC_1323 1348-1351 11.2 µM 0.541033459668191 0.285562309323341 no 951 0.294242260198596 327 6989654 SGTC_3106 9121286 49.47 µM 0.540341534400087 0.285794124888554 no 952 0.294480759867878 292 15943471 SGTC_2255 7941087 197.44 µM 0.540248463603643 0.285825313203935 no 953 0.294512847240588 330 935561 SGTC_1363 1636-0063 10.4 µM 0.540148524999835 0.285858804745044 no 954 0.294547304175999 328 6072185 SGTC_2531 methyl deoxycholate 70.07 µM 0.538845471182679 0.286295656341005 no 955 0.294996742569964 338 16667744 Haematoxylin. SGTC_2965 9082772 38.63 µM 0.536959911254087 0.286928354966916 no 956 0.295647652846747 267 16459634 SGTC_1100 amiodarone 5.07 µM 0.536820877374875 0.28697503392253 no 957 0.295695674569084 305 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1043 0916-0009 19.3 µM 0.536286434987592 0.287154500019674 no 958 0.29588030210605 352 3101130 SGTC_1405 3909-7894 12 µM 0.535841515164925 0.287303944897947 no 959 0.29603404370441 330 7104060 SGTC_1640 st009078 66.4 µM 0.535202389370464 0.287518686331595 no 960 0.2962549571267 333 690618 SGTC_1687 st020778 55.3625 µM 0.535088662033896 0.287556905808789 no 961 0.29629427483061 307 4259299 SGTC_1875 nocodazole 6 µM 0.534753733001203 0.287669476800549 no 962 0.296410080067345 313 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1352 1496-0991 99 µM 0.534120405038827 0.287882397774818 no 963 0.2966291165625 356 3000039 SGTC_1751 st044839 27.194 µM 0.532333230090149 0.288483636002994 no 964 0.297247610483524 300 5291326 SGTC_83 0170-0301 39.027 µM 0.53225508617853 0.288509938536847 no 965 0.297274667465311 323 3089716 SGTC_1227 3909-8010 46.6 µM 0.531785817349918 0.288667913944943 no 966 0.297437173376757 313 15982272 SGTC_78 0336-0123 156.75 µM 0.526587464515538 0.290420614986681 no 967 0.299240049468485 314 6765896 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.526168709189688 0.290562021053856 no 968 0.299385496404311 324 521171 SGTC_399 oxolinic acid 75 µM 0.525944577909878 0.290637719349769 no 969 0.299463357438123 321 4628 A DNA gyrase inhibitor. SGTC_54 0159-0055 9 µM 0.525298186535465 0.290856083794917 no 970 0.299687958933121 352 3319099 SGTC_1322 1348-1070 12 µM 0.524995956832433 0.290958209577076 no 971 0.299793000807569 324 6758089 SGTC_2018 5133068 143 µM 0.523050882720995 0.291615865916786 no 972 0.300469422332364 336 785362 SGTC_1084 voriconazole 435 nM 0.522955827686748 0.291648023086585 no 973 0.300502496456995 344 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3258 9138477 49.47 µM 0.522638712146401 0.291755315400775 no 974 0.300612847784115 343 4970355 SGTC_223 busulfan 5 mM 0.52161211633628 0.292102778110155 no 975 0.300970212734484 329 2478 A DNA alkylator. SGTC_3046 9092212 49.47 µM 0.518243988503717 0.2932441085338 no 976 0.302144023572935 356 25236637 SGTC_305 1682-2595 20.8 µM 0.515644225275636 0.294126480579513 no 977 0.30305145800227 334 226033 SGTC_2990 9074105 71.4286 µM 0.514943412819389 0.294364549458824 no 978 0.303296281591097 342 6502001 SGTC_1239 0337-0584 35.4 µM 0.514321791230255 0.294575791305837 no 979 0.303513514399325 350 914301 YML130C ERO1 SGTC_513 4245-1575 41.7 µM 0.513720639101791 0.294780143642726 no 980 0.303723659989902 325 719745 SGTC_1279 0874-0590 65.2 µM 0.513204736662054 0.294955568768046 no 981 0.303904056483394 337 3523074 SGTC_3067 9117431 49.47 µM 0.512375691470933 0.295237574248104 no 982 0.304194050186793 354 17150885 SGTC_402 epigallocatechin gallate 10 µM 0.512030895297893 0.295354895592131 no 983 0.30431469355169 337 65064 An antioxidant. SGTC_2768 sulfasalazine 50.2 µM 0.511878575306428 0.295406731263914 no 984 0.304367996740427 338 5384001 An antioxidant and salicylic acid derivative. SGTC_3336 9143619 71.43 µM 0.509689047817084 0.296152306409981 no 985 0.305134663557417 317 45595730 SGTC_1934 st074720 32.6 µM 0.509474513878681 0.296225405655047 no 986 0.30520982907752 326 17250992 SGTC_926 2268-1401 59.4 µM 0.508799892744332 0.296455326675174 no 987 0.305446247298082 328 2931578 SGTC_2628 lathosterol 100 µM 0.507205946875109 0.296998892028979 no 988 0.306005161404003 319 6710616 SGTC_483 fpl-64176 144 µM 0.507123983606723 0.297026855356481 no 989 0.306033913898138 351 3423 SGTC_1759 st043059 70 µM 0.506845362041472 0.29712192140434 no 990 0.306131662529688 349 669426 SGTC_367 0335-0881 7.1 µM 0.506583193578979 0.297211386333221 no 991 0.306223651535582 358 23828853 SGTC_3167 9103034 49.47 µM 0.505163340684471 0.297696124583269 no 992 0.306722058067372 335 5127859 SGTC_1111 tnp00062 510.699 nM 0.504721449672987 0.297847059890668 no 993 0.306877246693658 320 676306 SGTC_993 3909-8757 62.7 µM 0.503935176763683 0.298115710881717 no 994 0.307153465096891 324 4288324 YLR208W SEC13 SGTC_581 0958-0271 211 µM 0.503924406892191 0.29811939146023 no 995 0.307157249323018 318 4591145 SGTC_2452 5863136 48.41 µM 0.503184486629849 0.298372307039268 no 996 0.307417285388852 320 2184096 SGTC_2293 7624732 200 µM 0.502587676484344 0.298576376611519 no 997 0.307627097684084 328 894453 SGTC_1935 st074532 41.6 µM 0.500347534117328 0.299342922741697 no 998 0.308415194645864 351 2829742 SGTC_1495 4469-0029 237 µM 0.497214233063871 0.300416590236497 no 999 0.309518992770536 342 793680 SGTC_332 4112-0506 40.9 µM 0.495828976827146 0.30089182077483 no 1000 0.310007539421072 352 2790355 SGTC_1247 0448-0043 5.84 µM 0.494703875772454 0.301278050948985 no 1001 0.31040458264354 359 3089013 YGL099W LSG1 SGTC_37 0566-0070 1.56 µM 0.494277512743329 0.301424473241911 no 1002 0.310555102061993 358 1626686 SGTC_3043 9092303 49.47 µM 0.492119600568092 0.302166037766577 no 1003 0.311317398388114 312 25236084 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.489228588389263 0.303160812750895 no 1004 0.312339935951013 335 97141 SGTC_1848 st056003 16.4 µM 0.488931615287449 0.303263081805271 no 1005 0.312445056035601 324 146492 SGTC_2979 9012552 45.46 µM 0.485883689383301 0.304313590551296 no 1006 0.313524816678646 367 17100905 SGTC_1188 1403-0014 4.57 µM 0.484395102940734 0.304827240189034 no 1007 0.31405274659025 329 9614867 SGTC_1255 0566-0045 221 µM 0.483013874082043 0.305304189490159 no 1008 0.314542942559808 355 2788469 SGTC_1326 1431-2094 10.8 µM 0.482969103061559 0.305319654817468 no 1009 0.314558837202957 370 616278 SGTC_1420 4'-methoxyflavone 42 µM 0.482297824830098 0.30555157721624 no 1010 0.314797196127774 350 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1679 SEC14.276 6.7 µM 0.480527932582379 0.306163437808152 no 1011 0.31542602309899 380 1005053 YMR079W SEC14 SGTC_898 1000-0849 28.3 µM 0.479662589574714 0.306462788275817 no 1012 0.315733666610329 353 6751807 SGTC_1717 st033143 58.0435 µM 0.479531604538461 0.306508111549711 no 1013 0.315780245054752 375 674616 SGTC_3184 9108758 49.47 µM 0.479027369386499 0.306682613971829 no 1014 0.31595957901655 346 902885 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.478215538573418 0.306963659176878 no 1015 0.316248402049465 365 1273210 SGTC_3354 9151612 71.43 µM 0.476895401920908 0.307420915455895 no 1016 0.316718303189397 348 27261949 SGTC_1426 4048-4480 71.7 µM 0.472981575213784 0.308778307173614 no 1017 0.318113162114792 339 14224343 SGTC_640 3381-0960 37.1 µM 0.472881565449676 0.308813026876359 no 1018 0.31814883879121 348 1745025 SGTC_1697 st025554 27.742 µM 0.471897865957273 0.30915462209205 no 1019 0.318499845687293 340 1269519 SGTC_707 0865-0008 204 µM 0.467600319800322 0.310648902007314 no 1020 0.320035218092045 344 723043 SGTC_2555 cholic acid 100 µM 0.466426482810655 0.31105759658608 no 1021 0.320455129520238 346 6708657 Influences liver metabolism. SGTC_2117 5521686 200 µM 0.46551566738965 0.311374875648951 no 1022 0.32078110989637 345 803312 SGTC_1087 pterostilbene 9.05 µM 0.465218672902745 0.311478362854358 no 1023 0.320887433971057 363 5281727 Similar to reservatol, lowers cholesterol. SGTC_2228 7354201 200 µM 0.464774034482539 0.311633324171491 no 1024 0.321046642057901 379 753451 SGTC_280 3448-3607 3.04 µM 0.464627895905313 0.311684262338879 no 1025 0.321098975903398 348 626179 SGTC_304 1310-0298 97 µM 0.46415124830755 0.311850428007625 no 1026 0.321269693387612 373 1550234 SGTC_2980 9014342 25.29 µM 0.463851898317004 0.311954804966473 no 1027 0.321376928759906 369 2996599 SGTC_384 k007-0144 5.16 µM 0.461979815745652 0.312607902519283 no 1028 0.32204789751514 349 6824886 SGTC_869 0564-0080 44.1 µM 0.46176045057278 0.312684469167349 no 1029 0.322126557710646 329 6843321 SGTC_1439 4092-1168 46 µM 0.460881887100376 0.312991201667407 no 1030 0.322441673761685 362 2886240 SGTC_775 4577-0580 57.3 µM 0.460869249132391 0.312995614901114 no 1031 0.322446207577541 367 2006902 SGTC_204 PMA1.184 62.41 µM 0.460434829623452 0.313147332381262 no 1032 0.322602069731414 346 2252213 YGL008C PMA1 SGTC_2025 5147754 141 µM 0.459285509263982 0.313548875693843 no 1033 0.323014576160189 345 315777 YLR208W SEC13 SGTC_2285 7945142 200 µM 0.458130149206629 0.313952751931121 no 1034 0.323429469841967 365 2970608 SGTC_415 dibenzyl ketone 100 µM 0.457070540676758 0.314323352600213 no 1035 0.323810171949538 390 7593 SGTC_3061 glucosamine 200 µM 0.455504147401693 0.314871545387122 no 1036 0.324373292256386 347 91431 and experimental redox chemotherapeutic SGTC_2571 chrysanthemic acid 100 µM 0.454522497105361 0.315215303009613 no 1037 0.32472640168482 373 2743 An insecticide. SGTC_2791 5663188 71.43 µM 0.451942422798538 0.316119564765987 no 1038 0.325655230908337 396 54690634 SGTC_145 3737-0113 38.366 µM 0.450577530124511 0.316598376606901 no 1039 0.326147032172 382 6849351 SGTC_2755 lomerizine 42.69 µM 0.449552348728594 0.31695821814443 no 1040 0.326516626892227 347 3949 A calcium channel blocker. SGTC_1821 st053465 65.6 µM 0.448373050322266 0.317372369393639 no 1041 0.326941994024839 329 675086 SGTC_1886 st057356 49.9 µM 0.447161254607754 0.317798171502042 no 1042 0.327379317135918 350 24207747 SGTC_1157 4092-0394 27.6 µM 0.445352369895018 0.318434227785155 no 1043 0.328032563631569 332 3659885 SGTC_87 0100-0052 35.5 µM 0.444812966517241 0.318624001389129 no 1044 0.32822746153301 361 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_796 1234-0020 70.7 µM 0.443421244537386 0.319113858520434 no 1045 0.32873053614553 330 46495034 SGTC_951 1171-0579 82.7 µM 0.443187624829701 0.31919611878904 no 1046 0.328815014611944 359 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_525 k781-2675 26.7 µM 0.443167008196801 0.319203378577436 no 1047 0.32882247014592 358 3651118 YDL195W SEC31 SGTC_497 capsazepine 133 µM 0.442872371777108 0.319307137238084 no 1048 0.328929026113215 334 2733484 A calcium channel blocker. SGTC_596 1155-0152 116 µM 0.440699420807235 0.320072796602186 no 1049 0.329715307979022 357 280313 SGTC_875 0709-0210 25.7 µM 0.440083911492493 0.320289816531287 no 1050 0.329938166943121 363 6251364 SGTC_604 1000-0114 314 µM 0.439995665170977 0.320320935984205 no 1051 0.329970123454889 365 1572745 SGTC_3266 9136860 49.47 µM 0.438043939303459 0.321009521264674 no 1052 0.330677215936383 373 4871271 YPR165W RHO1 SGTC_2676 harmalol 100 µM 0.435008693557674 0.322081604843261 no 1053 0.331778058590185 353 5459187 A monoamine oxidase inhibitor SGTC_943 3253-1379 105 µM 0.433877954821082 0.322481374153628 no 1054 0.332188534552427 379 668464 SGTC_2241 6772625 37.8075 µM 0.431271174558477 0.323403775340808 no 1055 0.333135603581177 353 2285411 SGTC_663 1486-0733 13.9 µM 0.428778459666728 0.324286831275192 no 1056 0.334042228022593 368 722445 YPR165W RHO1 SGTC_2819 7996655 46.38 µM 0.428620555471283 0.324342802943876 no 1057 0.334099692002966 388 6456960 SGTC_1898 st060199 18.6 µM 0.428620006363174 0.324342997590958 no 1058 0.334099891839387 346 688866 SGTC_3072 9116419 49.47 µM 0.428319434720498 0.324449551013034 no 1059 0.334209285665041 349 17170162 SGTC_2658 polymyxin b sulfate 77.05 µM 0.427900537910287 0.324598074986491 no 1060 0.334361767731765 358 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2341 7987486 176.74 µM 0.427430366285896 0.324764812178029 no 1061 0.334532946831649 383 1258686 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.425830317773735 0.325332501103732 no 1062 0.335115746720169 341 2724 A muscle relaxant with antifungal properties. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.424392120814868 0.325843112098015 no 1063 0.335639933000482 383 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1644 st010134 20.9 µM 0.424097692104013 0.325947685081649 no 1064 0.335747284285958 386 3818134 SGTC_400 oxethazaine 37.5 µM 0.422449456373946 0.326533345777328 no 1065 0.33634849282126 374 4621 A local anesthetic. SGTC_765 1319-0117 244 µM 0.421574974764399 0.326844245466492 no 1066 0.336667637822905 351 3487746 YGL099W LSG1 SGTC_963 1269-2853 151 µM 0.420904357601382 0.327082747819647 no 1067 0.336912461545123 330 3668223 SGTC_3164 9100705 49.47 µM 0.419753293249356 0.327492283955766 no 1068 0.33733284428319 376 17174235 SGTC_2382 9035899 200 µM 0.418860138111258 0.32781020192922 no 1069 0.337659175435741 382 6462679 SGTC_1473 k844-0725 134 µM 0.418707907999919 0.327864400593918 no 1070 0.337714807776666 364 54682906 SGTC_1747 st037496 66.6 µM 0.418386052707107 0.32797900304639 no 1071 0.337832441142604 353 723305 SGTC_1605 st000082 49.1 µM 0.418340036100626 0.327995389422939 no 1072 0.33784926082867 387 1114022 SGTC_626 0214-0009 33 µM 0.417077064409788 0.328445259037488 no 1073 0.338311020195017 376 3437874 SGTC_2952 9073731 13.78 µM 0.41702316957189 0.328464461880444 no 1074 0.33833073028661 336 16457353 SGTC_997 3996-0078 137 µM 0.416610795065569 0.328611406769649 no 1075 0.338481556036306 365 735687 SGTC_559 1550-0661 158 µM 0.416428153610073 0.328676497412679 no 1076 0.338548365330185 379 5830875 SGTC_2276 7947513 42.08 µM 0.415732053651034 0.328924624519653 no 1077 0.338803041647021 364 2105100 SGTC_1957 st077035 62.4 µM 0.414671693942885 0.329302738108501 no 1078 0.339191128284385 372 705593 SGTC_1661 st013063 9.66 µM 0.414660329932653 0.329306791346604 no 1079 0.33919528838342 374 721395 SGTC_3272 9137413 49.47 µM 0.414035829246646 0.32952956484695 no 1080 0.339423933642584 374 17614870 SGTC_196 k015-0023 18.111 µM 0.411622189514708 0.330391132949428 no 1081 0.340308182485323 358 5211998 SGTC_1783 st039459 87.517 µM 0.411300469381378 0.330506041599167 no 1082 0.340426112725754 430 729761 SGTC_2116 5511452 16.8835 µM 0.410226165173504 0.330889866124865 no 1083 0.34082002438062 392 870744 SGTC_2776 terbinafine 19.92 µM 0.409564063599238 0.331126508602131 no 1084 0.341062881535092 343 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2867 9039098 71.43 µM 0.409185749476601 0.331261752578444 no 1085 0.341201675756898 377 6463460 SGTC_1732 st034308 51.822 µM 0.408535366451527 0.331494310240557 no 1086 0.341440335634687 342 830119 SGTC_2307 7538926 6.34 µM 0.407981757545999 0.331692315550847 no 1087 0.341643533949044 358 96582 SGTC_622 1348-1566 26.3 µM 0.407896293867134 0.331722886921526 no 1088 0.341674906891596 376 7340407 SGTC_2427 5545055 42.75 µM 0.405959561398634 0.332415979207977 no 1089 0.342386156691915 374 5372858 SGTC_1936 st074407 74.3 µM 0.40313530973678 0.33342771252942 no 1090 0.343424343051782 360 809813 SGTC_2229 7354935 190 µM 0.402650164546759 0.333601628648702 no 1091 0.343602800178651 394 318112 SGTC_268 camptothecin 39.6153 µM 0.401834643538424 0.333894059332839 no 1092 0.343902862187898 377 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1731 st035964 63 µM 0.401732790761656 0.333930588938091 no 1093 0.343940344711773 381 6739575 SGTC_97 0535-0701 19.132 µM 0.401561995843386 0.333991848246595 no 1094 0.344003201861044 369 2832013 YGL099W LSG1 SGTC_2524 avocatin b 10.57 µM 0.401527830810175 0.334004102809101 no 1095 0.344015776034798 365 6710748 SGTC_2847 9005661 71.43 µM 0.401436261507577 0.334036948425212 no 1096 0.344049478252448 373 2991449 SGTC_2482 5981709 142.65 µM 0.39997285686442 0.334562039345696 no 1097 0.344588254450288 377 877755 SGTC_1655 st012546 55.1 µM 0.398867561890128 0.334958849979699 no 1098 0.344995395911489 394 720985 YLR208W SEC13 SGTC_1060 3448-7350 82 µM 0.398204923495273 0.335196831404548 no 1099 0.345239568502871 366 570178 SGTC_1476 4112-3294 3.34 µM 0.397351431814886 0.335503453787968 no 1100 0.345554162684667 386 704369 SGTC_2294 7971431 200 µM 0.396711549234114 0.335733407618665 no 1101 0.345790091267041 412 5741572 SGTC_137 0438-0332 85.389 µM 0.396659757150558 0.335752022769696 no 1102 0.345809189943235 383 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_549 1661-1316 519 µM 0.395376456131574 0.336213396434016 no 1103 0.346282540948752 388 2857282 SGTC_583 1488-1091 88.9 µM 0.394212290575814 0.336632151938658 no 1104 0.346712156167828 397 4303273 SGTC_2060 5238662 140 µM 0.393392323799799 0.336927219295665 no 1105 0.347014869160266 362 790130 SGTC_160 3453-0671 289.699 µM 0.392685185727547 0.337181765549765 no 1106 0.347276006808919 369 5322268 SGTC_2635 hydroquinidine 100 µM 0.392512972038248 0.337243768060558 no 1107 0.347339614254522 346 442912 An experimental heart treatment. SGTC_2942 9052777 62.25 µM 0.391406852714483 0.337642112193742 no 1108 0.347748263910098 393 6469503 SGTC_984 1492-0255 2.91 µM 0.391379923097715 0.337651812563655 no 1109 0.347758215116107 389 1585198 SGTC_1044 1222-0021 1.78 µM 0.391299235738882 0.337680877760671 no 1110 0.347788031858243 368 4306703 SGTC_2446 5162541 200 µM 0.391134400651192 0.337740257658038 no 1111 0.347848946993607 376 1549321 SGTC_1270 0831-1170 17.3 µM 0.388999107811905 0.33850983633627 no 1112 0.348638403187965 376 6764716 SGTC_2390 9097792 176.6 µM 0.388961807841954 0.338523285586486 no 1113 0.348652199496922 375 4497149 SGTC_2075 5212009 200 µM 0.387983389896706 0.33887614725808 no 1114 0.349014162816124 413 780898 SGTC_104 0074-0074 590.992 µM 0.387120076687625 0.339187614434837 no 1115 0.349333657560203 365 3943124 SGTC_2813 7971799 71.43 µM 0.385567840149702 0.339747908595063 no 1116 0.349908377379853 379 2234054 SGTC_2910 7948405 25.97 µM 0.383671924475001 0.340432737467416 no 1117 0.350610811992436 393 2971328 SGTC_191 3914-0123 66.505 µM 0.38289354978225 0.340714048897931 no 1118 0.350899347061593 395 3144412 SGTC_1071 trifluoperazine 6.31 µM 0.382729327840891 0.34077341147106 no 1119 0.350960233348834 408 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2445 5742597 35.57 µM 0.38192809160033 0.341063097052185 no 1120 0.351257351435635 369 1774255 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.381640197701866 0.341167207489703 no 1121 0.351364131783564 378 23847180 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.381026770350787 0.341389080199167 no 1122 0.351591692179629 397 61125 An anti-inflammatory. SGTC_3213 9129884 49.47 µM 0.380950793856758 0.341416564223876 no 1123 0.351619880542931 368 17190742 SGTC_385 1494-0393 12.4 µM 0.38058206106099 0.341549962965445 no 1124 0.351756697257032 386 3090647 SGTC_2750 bromebric acid 70.15 µM 0.38041615876707 0.341609988920915 no 1125 0.351818260851918 375 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1389 3405-0187 19 µM 0.380416107850817 0.341610007343799 no 1126 0.351818279746693 372 799890 SGTC_57 miconazole 162.5 nM 0.379881621814149 0.341803419702926 no 1127 0.352016645086874 390 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2627 acetyl isogambogic acid 100 µM 0.379752667857131 0.341850089984793 no 1128 0.352064510173239 378 6857789 A caspase activator and apoptosis inducer. SGTC_1450 4112-4260 37.6 µM 0.379481199538184 0.341948346152119 no 1129 0.352165281352991 393 1633175 SGTC_601 0986-0029 62.9 µM 0.377257283775512 0.342753680348051 no 1130 0.352991206730023 393 24747981 SGTC_754 3474-0146 171 µM 0.375748221838372 0.343300556047059 no 1131 0.353552042280982 356 24762078 SGTC_755 1995-0008 37.3 µM 0.37563821418136 0.343340435064833 no 1132 0.353592938546118 364 689533 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.374304037778247 0.343824227821684 no 1133 0.354089064177806 381 688788 SGTC_2359 9039622 200 µM 0.374292709270704 0.343828336808185 no 1134 0.354093277848518 397 6463596 SGTC_1260 0700-1617 7.75 µM 0.373464290973926 0.344128864098824 no 1135 0.354401458792808 374 2853078 SGTC_900 1112-0045 141 µM 0.371680713806076 0.344776230694561 no 1136 0.355065293039202 377 56211 YIL048W NEO1 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.371638172627435 0.344791676987015 no 1137 0.355081131934013 388 2346 DNA damaging agent; causes G2/M arrest. SGTC_2752 diclazuril 33.15 µM 0.369339534856528 0.345626674292404 no 1138 0.35593733042771 381 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_179 1273-0063 6.77 µM 0.367523319269202 0.346286959956017 no 1139 0.356614350388994 411 3108139 SGTC_403 arphamenine a 50 µM 0.367058519218495 0.346456013343364 no 1140 0.356787683885443 412 5487158 An arginine aminopeptidase inhibitor. SGTC_257 daunorubicin 18.5 µM 0.366920509723802 0.346506214953158 no 1141 0.356839156159721 405 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2618 avocadyne 43.43 µM 0.365917677188525 0.346871080979078 no 1142 0.357213252651925 404 3015189 SGTC_201 4262-0159 12.803 µM 0.365213511065752 0.347127366488083 no 1143 0.357476016745032 406 1341029 SGTC_2778 tioconazole 65.09 nM 0.364751727297066 0.347295473453118 no 1144 0.357648371012186 388 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_487 nimodipine 119 µM 0.363224898033821 0.347851511489378 no 1145 0.358218444981839 411 4497 L-type voltage-gated calcium channels inhibitor SGTC_1518 st038567 90.8 µM 0.360059342931977 0.34900537974265 no 1146 0.359401378067416 395 77966 SGTC_1193 1488-0126 41.5 µM 0.359969636560654 0.34903809879127 no 1147 0.359434920056044 374 1384710 SGTC_935 2996-0153 430 µM 0.359679860721722 0.349143797833842 no 1148 0.359543277149494 392 23738523 SGTC_2011 4012611 177 µM 0.358834262660525 0.349452306253143 no 1149 0.359859539712572 397 2049887 SGTC_1924 st058459 75.1 µM 0.358108341462235 0.349717231070595 no 1150 0.360131118442076 401 688683 SGTC_2594 a-mangostin 100 µM 0.356277886344286 0.350385580090999 no 1151 0.360816234189232 418 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3133 9127736 49.47 µM 0.355229795450015 0.350768475449087 no 1152 0.361208722447469 395 27243420 SGTC_3058 9093861 49.47 µM 0.354796208839148 0.350926920479793 no 1153 0.361371134382201 404 17217477 SGTC_3051 9093778 49.47 µM 0.354290829367605 0.35111163340757 no 1154 0.361560469864453 431 17217378 SGTC_133 0724-0033 378.92 µM 0.353696891622064 0.351328758779925 no 1155 0.36178302617166 406 280309 SGTC_2284 7945075 39.21 µM 0.352899989240232 0.351620158009722 no 1156 0.362081709449015 417 1245402 SGTC_2210 7115885 190.385 µM 0.351597102053315 0.352096765906446 no 1157 0.362570219418564 398 2927039 SGTC_883 0850-0245 24.6 µM 0.350441572918068 0.352519663418476 no 1158 0.36300366565834 403 6823229 YPR165W RHO1 SGTC_2983 9022671 12.99 µM 0.350185145147609 0.35261353492153 no 1159 0.363099877146294 421 6405161 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.349855886504341 0.352734081064341 no 1160 0.363223427386143 398 688751 SGTC_2733 amorolfine 100 µM 0.34935073396916 0.352919053137274 no 1161 0.363413007301723 410 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_542 3381-0244 89.3 µM 0.349311586968485 0.352933389075209 no 1162 0.363427700271682 436 1112843 SGTC_2347 9049783 174.81 µM 0.348368496770416 0.35327881914325 no 1163 0.363781729216575 411 6467988 YPL169C MEX67 SGTC_2059 5238311 157 µM 0.347437584746652 0.353619907240063 no 1164 0.364131300657068 383 703021 SGTC_904 1141-0088 396 µM 0.345629098959802 0.35428287601738 no 1165 0.364810737213121 396 1378119 SGTC_2692 st077426 47.7 µM 0.34522108022341 0.354432511857967 no 1166 0.364964086050693 424 25238571 SGTC_49 0717-0965 32.132 µM 0.344759605691293 0.354601779033083 no 1167 0.365137551624531 409 5889349 YGL099W LSG1 SGTC_2206 7254556 146.969 µM 0.344440803469689 0.354718731298573 no 1168 0.3652574036341 381 4398905 SGTC_2023 5144124 124 µM 0.344099566583078 0.354843928872036 no 1169 0.365385704420452 406 2830192 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.344074212195186 0.354853231856383 no 1170 0.365395237953524 420 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1534 6-azauridine 81.6 µM 0.343816748870075 0.354947704716545 no 1171 0.365492051749135 392 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2956 9076196 2.52 µM 0.343409042697147 0.355097325503175 no 1172 0.365645378811167 421 16423868 SGTC_2020 4017018 200 µM 0.342559842996512 0.355409038143141 no 1173 0.365964808330772 405 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1530 rhein 70.4 µM 0.340736298004121 0.356078726877564 no 1174 0.366651055128147 396 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1506 4226-2149 212 µM 0.340311062601967 0.356234956625813 no 1175 0.366811143530077 396 991114 SGTC_1591 genipin 88.4 µM 0.340275045621759 0.356248190226142 no 1176 0.366824703909797 393 442424 A DNA cross-linking agent. SGTC_308 4092-1169 104 µM 0.339232082546393 0.356631477749862 no 1177 0.367217451144633 416 2268590 YDL196W YDL196W SGTC_1492 4158-0558 28.5 µM 0.336526014320356 0.35762662868316 no 1178 0.368237118868317 390 3967268 SGTC_1737 st035557 69.7 µM 0.335416480703588 0.358034937761657 no 1179 0.368655468751142 388 5716916 SGTC_1259 0671-0132 43 µM 0.334758514397199 0.358277146542116 no 1180 0.368903628666709 371 X1259 SGTC_843 0310-0051 143 µM 0.33375319751093 0.358647331208108 no 1181 0.369282901575259 422 2065037 SGTC_376 3970-0862 59.1 µM 0.333690488803084 0.358670426642813 no 1182 0.369306563723517 410 3135186 SGTC_908 3448-7491 47.7 µM 0.332426399760205 0.359136097069254 no 1183 0.369783653393921 367 1203031 SGTC_1477 0139-0234 16 µM 0.332342234256068 0.359167109752378 no 1184 0.369815426078564 375 620880 SGTC_363 0455-0021 3.06 µM 0.331330276385396 0.359540061116586 no 1185 0.370197512186963 408 4597466 SGTC_209 4077-0173 175.592 µM 0.330678267655435 0.35978042617061 no 1186 0.370443759775761 379 15993494 SGTC_2584 androsterone 48.74 µM 0.327897783021786 0.36080608214104 no 1187 0.371494475021767 381 2754130 A steroid. SGTC_2859 9028643 45.46 µM 0.32778689445593 0.360847007172039 no 1188 0.371536398539532 400 17151580 SGTC_80 0159-0065 512.242 µM 0.327354637408509 0.361006553102681 no 1189 0.371699836028208 401 1548079 SGTC_1288 0973-0013 65.5 µM 0.326333123540273 0.361383689600244 no 1190 0.372086164881143 397 4315430 SGTC_2476 5806916 10.51 µM 0.326260659838556 0.36141044786548 no 1191 0.372113575004379 418 2870194 SGTC_2100 5377183 190 µM 0.32352803464607 0.362420002810394 no 1192 0.37314768978485 397 2844202 SGTC_76 0433-0009 400.328 µM 0.322947173278264 0.362634722821479 no 1193 0.373367624839944 434 2841569 SGTC_503 tyrphostin 8 294 µM 0.321150328803235 0.363299213927349 no 1194 0.374048235880156 438 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2869 9037858 32.47 µM 0.320059456328776 0.363702830442207 no 1195 0.374461629727496 388 27187042 SGTC_1114 scopoletin 1.73284 µM 0.319788564428833 0.363803082349376 no 1196 0.37456430852306 432 5280460 A coumarin with genotoxic properties. SGTC_2031 5180455 200 µM 0.319709875659789 0.363832205304634 no 1197 0.374594136361224 410 29949 SGTC_2800 7887935 81.82 µM 0.318966747673367 0.364107278028463 no 1198 0.374875864132233 387 2961002 SGTC_1383 3049-0032 20.7 µM 0.31811899428282 0.364421163898723 no 1199 0.375197338058467 428 712864 SGTC_2807 7945238 51.95 µM 0.317692275750418 0.364579193462271 no 1200 0.375359185485783 429 17148797 SGTC_60 0986-0278 202 µM 0.315016555580472 0.365570634704161 no 1201 0.376374541908975 430 3110598 SGTC_3220 9131269 49.47 µM 0.311603883107294 0.3668364442831 no 1202 0.377670791393919 426 17722206 SGTC_3205 9113483 49.47 µM 0.311491788116459 0.3668780465953 no 1203 0.377713392366505 452 17018033 SGTC_1370 2001-0092 44.6 µM 0.310862723289013 0.367111543215992 no 1204 0.377952491948295 430 790957 SGTC_2066 5222451 176 µM 0.309811861215588 0.367501712384691 no 1205 0.378352015587862 400 2281147 SGTC_3039 9090270 49.47 µM 0.309595014154077 0.367582241455613 no 1206 0.378434474132249 402 17173750 SGTC_1407 3909-7909 12.3 µM 0.308821396259595 0.367869582277521 no 1207 0.378728696155209 408 4411780 SGTC_447 ml7 120 µM 0.307087149285772 0.368513993022107 no 1208 0.379388519416752 416 4216 Selective myosin light chain kinase inhibitor. SGTC_1191 1487-1166 10.6 µM 0.305159070604639 0.36923086195543 no 1209 0.380122501729498 428 3955771 SGTC_2724 maprotiline 69.64 µM 0.301979848529313 0.370413904718282 no 1210 0.381333712398805 430 4011 A tricyclic antidepressant. SGTC_421 streptovitacin 30 mM 0.301215374691707 0.370698561842964 no 1211 0.381625133320457 401 91467 include heat shock SGTC_1028 k015-0029 4.8 µM 0.299168385528609 0.371461120608288 no 1212 0.382405784968501 400 4588309 SGTC_3118 9124250 49.47 µM 0.299005501347149 0.371521821086177 no 1213 0.382467924003289 433 1504786 SGTC_1485 3909-9022 254 µM 0.296643855541715 0.37240227114967 no 1214 0.38336921260197 412 714516 SGTC_1568 digitonin 820 nM 0.296401715961139 0.37249258150228 no 1215 0.383461657514089 434 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_39 0986-0283 58.349 µM 0.296318575666259 0.372523591801887 no 1216 0.383493400642666 393 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2842 9000675 19.48 µM 0.295446125364688 0.372849054753495 no 1217 0.383826551011689 433 2989072 SGTC_2727 riluzole 51.77 µM 0.294013320963075 0.373383751704281 no 1218 0.384373862181351 423 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1216 1165-0504 9.65 µM 0.29366225876816 0.373514799068548 no 1219 0.38450799822553 425 6304004 SGTC_1335 1486-0900 202 µM 0.293482651566465 0.373581849969536 no 1220 0.384576629019516 404 X1335 SGTC_3064 1327-0027 10 µM 0.293140686921922 0.37370952267555 no 1221 0.38470730919739 440 16000455 YPR107C YTH1 SGTC_1343 1487-0095 224 µM 0.292877909994956 0.373807640017669 no 1222 0.384807737064087 438 4560101 YGL055W OLE1 SGTC_1015 4130-4525 82 µM 0.292698869652073 0.373874495939291 no 1223 0.384876166980581 405 1363237 SGTC_3346 9158254 43.5805 µM 0.288928540090092 0.375283263006217 no 1224 0.386318031431538 417 17639500 SGTC_1422 4031-0024 15.5 µM 0.288749702795263 0.375350126282911 no 1225 0.386386462290108 444 782427 SGTC_1983 st071813 46.9 µM 0.288371033944399 0.375491714479923 no 1226 0.386531368977052 415 11838595 SGTC_2181 6316240 54.2555 µM 0.287536950574817 0.375803646006801 no 1227 0.386850606703837 403 12779990 SGTC_836 0330-0104 1.35 µM 0.287274233897385 0.375901913935684 no 1228 0.38695117495935 382 46494820 SGTC_756 0508-1999 28.3 µM 0.286539674055203 0.376176715258966 no 1229 0.387232405598255 404 6753853 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.286196076224711 0.37630527793318 no 1230 0.387363974417943 407 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1768 st044301 37.178 µM 0.285552093719188 0.376546271340792 no 1231 0.387610599923711 449 3931349 SGTC_615 k087-0205 167 µM 0.285152861494215 0.376695697605559 no 1232 0.387763516375808 435 9642773 SGTC_24 0417-1663 219 µM 0.283974775654705 0.377136743996269 no 1233 0.388214855664901 424 4329390 SGTC_2898 9056270 58.44 µM 0.28272385029877 0.37760523521972 no 1234 0.388694265976625 417 19154699 SGTC_795 0685-0265 78 µM 0.281518390408443 0.3780568693568 no 1235 0.389156412352884 418 302754 SGTC_300 r073-0011 5.04 µM 0.281422712979171 0.378092722735873 no 1236 0.389193099667796 401 2735780 SGTC_1320 1313-0481 95.3 µM 0.28047203360711 0.378449029563803 no 1237 0.389557689354896 425 6813365 YLR208W SEC13 SGTC_149 3970-0822 46.1 µM 0.279994021094151 0.378628223805507 no 1238 0.389741045992027 410 3114250 YBL034C STU1 SGTC_2378 9074213 121.43 µM 0.279885328421143 0.378668973455604 no 1239 0.389782741889491 436 657714 SGTC_1489 4065-0444 182 µM 0.279668076413553 0.37875042680871 no 1240 0.389866086335165 448 2877968 SGTC_120 rhodamine 6G 52.259 µM 0.277408457925502 0.379597934476337 no 1241 0.390733243951065 428 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2698 st077697 67.5 µM 0.277387514269945 0.379605792457583 no 1242 0.390741283897401 418 3154499 SGTC_2686 alizarin 95.37 µM 0.275605908844971 0.380274425865251 no 1243 0.391425385391527 375 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1125 tnp00248 1.32998 µM 0.275341502891952 0.380373687506999 no 1244 0.391526940765461 427 24207736 SGTC_1003 4049-0218 100 µM 0.273540722129707 0.381049934662716 no 1245 0.392218796865711 429 295161 SGTC_675 1309-0189 238 µM 0.272367767896823 0.381490609743143 no 1246 0.392669626823441 384 4246530 SGTC_3010 9080089 71.4286 µM 0.272205049888129 0.381551754518784 no 1247 0.392732179574402 416 17027233 SGTC_121 0557-0495 61.343 µM 0.271440421705118 0.381839119488423 no 1248 0.393026158277061 454 3104427 SGTC_2120 5538279 151.968 µM 0.271383364723305 0.381860565435866 no 1249 0.393048097580551 413 2058197 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.269583484017734 0.382537270489484 no 1250 0.393740353952889 440 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1788 fluconazole 20 µM 0.268685675267347 0.382874955861906 no 1251 0.394085788021967 446 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1354 1498-1681 81 µM 0.268637099748054 0.382893228711321 no 1252 0.394104479948266 417 5754243 SGTC_2304 7443016 91.4 µM 0.267035465081511 0.383495867842264 no 1253 0.394720927524047 431 939854 SGTC_510 ag-490 170 µM 0.266330121843763 0.383761353360028 no 1254 0.394992488346422 433 5328779 SGTC_852 0418-0143 439 µM 0.265910444215204 0.383919342543919 no 1255 0.395154090637422 417 5369229 SGTC_745 0469-0705 296 µM 0.265277117965147 0.384157797056738 no 1256 0.39539799522524 438 3486736 SGTC_1268 0828-0275 2.46 µM 0.263788297376836 0.384718527461994 no 1257 0.395971526310726 420 745337 SGTC_2233 sulbentine 40.3845 µM 0.263142361604467 0.384961879581674 no 1258 0.396220427138714 423 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_974 1326-0144 138 µM 0.262597101378103 0.385167338121216 no 1259 0.396430567221175 431 5411856 SGTC_1845 st056753 3.01 µM 0.262538261005342 0.385189511586062 no 1260 0.396453245754395 400 5375839 SGTC_879 0831-1030 162 µM 0.262154126895001 0.38533427828942 no 1261 0.396601309135918 430 1549252 SGTC_2280 7785178 200 µM 0.26171954240879 0.385498077238376 no 1262 0.396768836445 412 2954328 SGTC_1204 4049-0315 18.3 µM 0.261517519820989 0.385574228393287 no 1263 0.396846720313298 396 588402 SGTC_2889 9059656 51.95 µM 0.261346828938488 0.385638572695289 no 1264 0.396912528371159 410 3949838 SGTC_134 0269-0018 6.916 µM 0.260123915051367 0.386099659041221 no 1265 0.397384095593727 423 4378915 SGTC_2237 6667747 47.222 µM 0.259769182739145 0.386233437130685 no 1266 0.397520911847564 455 729940 YDL015C TSC13 SGTC_3023 9089636 49.47 µM 0.258932372533821 0.386549071955424 no 1267 0.397843710033157 423 17249241 SGTC_3349 9149703 23.001 µM 0.258456020255353 0.386728779895725 no 1268 0.398027493412093 415 4910494 SGTC_3296 9122258 64.045 µM 0.257863270282198 0.386952433770089 no 1269 0.398256216244477 436 4730474 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.254360593265391 0.388274812874666 no 1270 0.39960849598706 414 4330530 SGTC_1743 st037606 46.3785 µM 0.253781858751155 0.388493429928136 no 1271 0.399832044669215 393 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_124 0136-0217 7.121 µM 0.253562651748847 0.388576244635876 no 1272 0.39991672667713 421 3976905 SGTC_2552 juarezic acid 87.02 µM 0.252214541189023 0.389085661584002 no 1273 0.400437619538678 403 1549512 SGTC_2809 7964133 12.99 µM 0.251540449967243 0.389340455220818 no 1274 0.400698146344757 450 1253665 SGTC_526 4469-0568 170 µM 0.251326838803896 0.389421206103677 no 1275 0.400780713287775 422 2901964 SGTC_466 geldanamycin 89.2 µM 0.251291709855127 0.389434486267808 no 1276 0.400794292075281 435 5288382 HSP90 inhibitor. SGTC_657 3534-0529 86.7 µM 0.251103038304283 0.389505813957374 no 1277 0.400867223461336 437 1049549 SGTC_2551 apiole 73.87 µM 0.250713276466435 0.389653176052013 no 1278 0.401017897661281 439 10659 A possible DNA adduct former. SGTC_2887 9044784 58.44 µM 0.25044500319571 0.38975461467625 no 1279 0.401121615346125 465 6465546 SGTC_2481 5478948 45.16 µM 0.25003733466233 0.389908775362814 no 1280 0.401279238260876 408 77792 SGTC_2603 homopterocarpin 100 µM 0.24954331456221 0.390095613278562 no 1281 0.401470270090038 421 101795 A weak amylase inhibitor. SGTC_3161 9100388 49.47 µM 0.248295021954067 0.390567829364671 no 1282 0.401953075170861 431 25236368 SGTC_2045 5106652 78.05 µM 0.247998522514681 0.390680015768171 no 1283 0.402067774982364 460 673349 SGTC_2502 avocadyne acetate 18.59 µM 0.247986513648292 0.390684559751148 no 1284 0.402072420749747 391 3952079 SGTC_383 2324-0395 7.37 µM 0.247652137979159 0.390811088705948 no 1285 0.40220178335726 443 3146421 SGTC_2449 5812982 45.77 µM 0.247548674439713 0.390850242023743 no 1286 0.40224181330072 439 776185 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.24705446072497 0.39103728071931 no 1287 0.40243303824793 393 6708561 SGTC_3087 9117406 49.47 µM 0.245797872459666 0.391512958911947 no 1288 0.402919352040213 388 42546093 SGTC_1694 st024011 44.9 µM 0.245780400854081 0.391519573887833 no 1289 0.402926114808676 443 2787533 SGTC_281 1672-3440 14.9 µM 0.245759533581715 0.391527474548196 no 1290 0.40293419198256 449 6833000 SGTC_1403 3909-7815 62.9 µM 0.245600717392916 0.391587606190547 no 1291 0.402995666921323 444 6615483 SGTC_1349 flufenamic acid 69 µM 0.245026969287665 0.391804862645426 no 1292 0.403217774637458 430 3371 A non-steroidal anti-inflammatory. SGTC_520 3584-0023 682 µM 0.24471010272004 0.391924862359284 no 1293 0.403340452501201 398 1340790 SGTC_2195 6536160 144.242 µM 0.244258899662192 0.392095754037373 no 1294 0.403515156411611 420 3834386 SGTC_1909 st060837 51.5 µM 0.242850954093694 0.392629142482586 no 1295 0.404060430599463 435 678937 SGTC_1143 3454-2408 5.08 µM 0.242757297678831 0.392664630601462 no 1296 0.404096708816136 430 X1143 SGTC_2996 9066192 71.4286 µM 0.24225468285447 0.392855095737274 no 1297 0.404291412921794 423 6472854 SGTC_1724 st037281 8.293 µM 0.241079382869411 0.393300573979377 no 1298 0.404746795836422 415 574124 YDL195W SEC31 SGTC_680 0417-1641 114 µM 0.239489291890739 0.393903494283167 no 1299 0.405363099374631 430 2835990 SGTC_448 monastrol 171 µM 0.236135713889351 0.395175914502721 no 1300 0.406663680868471 449 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3168 9103419 49.47 µM 0.235810098664192 0.395299519772286 no 1301 0.406790015759922 462 16649256 SGTC_2224 6650123 117.647 µM 0.235349711584473 0.395474303128967 no 1302 0.406968657103007 449 2908370 SGTC_81 0411-0046 9.971 µM 0.234851279798357 0.3956635536478 no 1303 0.40716208253566 419 12925265 SGTC_235 0330-0087 5 mM 0.233875442916331 0.396034142218726 no 1304 0.407540839134783 431 46494818 YHR062C RPP1 SGTC_1879 gemcitabine 100 µM 0.2326917717584 0.396483785060426 no 1305 0.408000379520958 437 60750 A nucleoside analog which inhibits DNA replication. SGTC_1445 4239-0156 97.7 µM 0.232358707783875 0.396610331396414 no 1306 0.408129708845683 460 4008346 SGTC_2138 5575593 77.673 µM 0.231601111662846 0.396898217578255 no 1307 0.408423922002167 453 762213 SGTC_2537 larixol 68.93 µM 0.230971405497983 0.397137548410805 no 1308 0.408668508272373 464 6708759 SGTC_86 0417-1630 471.922 µM 0.230755098924826 0.397219768447831 no 1309 0.408752532843199 433 3634867 SGTC_1058 3448-5425 97.3 µM 0.230441889512222 0.397338830203775 no 1310 0.40887420688089 457 7279705 SGTC_336 4111-0029 111 µM 0.229674889001261 0.397630434064122 no 1311 0.40917220449493 456 3131175 SGTC_1653 st012112 65 µM 0.229585494564405 0.397664424420204 no 1312 0.409206939740942 445 720429 SGTC_880 0833-0487 87.2 µM 0.228831818141504 0.397951024905739 no 1313 0.409499817778663 421 76075 SGTC_759 3486-0358 89.3 µM 0.22861210255027 0.398034586514918 no 1314 0.409585208593483 456 875103 SGTC_3104 9120930 49.47 µM 0.225005078223222 0.399407065737765 no 1315 0.410987661851911 453 17014836 SGTC_27 0485-0001 32.618 µM 0.224435293918893 0.399623983910674 no 1316 0.411209305244068 475 2054479 SGTC_2250 alverine citrate 130 µM 0.224182968473469 0.399720054681464 no 1317 0.411307467705472 437 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3142 9086498 49.47 µM 0.223483894483127 0.399986252860976 no 1318 0.411579458258251 460 25236367 SGTC_459 nigericin 15.3 µM 0.223235162775026 0.400080977841217 no 1319 0.411676243213662 459 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1008 4106-0037 6 µM 0.22312904529287 0.400121392557866 no 1320 0.411717536632751 474 2905394 SGTC_744 1594-0068 283 µM 0.22216227858761 0.400489633718376 no 1321 0.41209377883636 429 668392 SGTC_1608 st001473 40.5 µM 0.22088463644731 0.400976422908123 no 1322 0.412591130158177 470 7292267 SGTC_1900 st060200 72.8 µM 0.220273186654506 0.401209443341905 no 1323 0.41282920063969 425 688945 SGTC_2164 5685496 200 µM 0.219931832070422 0.401339547144993 no 1324 0.412962122398821 407 759046 SGTC_90 0870-0863 4.608 µM 0.219460159037259 0.401519338488454 no 1325 0.413145805925291 458 1738164 SGTC_189 3970-0742 2.116 µM 0.219244412845272 0.401601583124005 no 1326 0.413229830257997 467 2891807 SGTC_1761 st044296 37 µM 0.219109349874843 0.401653072716276 no 1327 0.413282433793413 423 1826700 SGTC_2856 9022925 19.48 µM 0.217558581694516 0.402244388875852 no 1328 0.413886529233243 428 4944862 SGTC_2215 7188065 200 µM 0.217533335668103 0.402254017174896 no 1329 0.413896365410232 464 940217 SGTC_3222 9128301 49.47 µM 0.21660927841757 0.402606473778698 no 1330 0.414256427139125 479 4911358 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.215503484755355 0.40302835285796 no 1331 0.414687397724634 468 1241132 A phosphatase inhibitor. SGTC_2238 6671620 73.2395 µM 0.21306711093886 0.40395826867889 no 1332 0.415637308641512 396 729941 SGTC_1464 k208-0027 110 µM 0.212835128346999 0.404046840254733 no 1333 0.41572778148274 487 X1464 SGTC_1443 4112-3303 14 µM 0.212427191529264 0.404202603554769 no 1334 0.415886887023281 461 704433 SGTC_309 k408-0051 1.48 µM 0.210397940675226 0.404977661541251 no 1335 0.416678549893945 467 3640463 SGTC_13 0199-0087 65 µM 0.210176242873967 0.405062360094558 no 1336 0.416765060440612 448 4589825 SGTC_3163 9099914 49.47 µM 0.210139409927333 0.405076432371364 no 1337 0.416779433722294 469 16268368 SGTC_16 erodoxin 22.806 µM 0.209832876585953 0.405193550270701 no 1338 0.416899056216604 452 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1990 st072050 59.8 µM 0.207998155193784 0.405894723646564 no 1339 0.417615203898518 430 17233948 SGTC_1298 1079-1278 263 µM 0.205851017969155 0.406715676005509 no 1340 0.418453643964536 459 2840950 SGTC_2346 9031566 143.75 µM 0.205550820601781 0.406830488452665 no 1341 0.418570898276058 455 4771086 SGTC_468 gf-109203x 121 µM 0.205286610744141 0.406931543867272 no 1342 0.418674102186303 460 2396 A protein kinase C inhibitor. SGTC_2177 5811945 192 µM 0.205138400083771 0.406988234434331 no 1343 0.418731997707202 468 5343475 SGTC_3145 9085516 49.47 µM 0.204298447447507 0.407309553042753 no 1344 0.419060141572838 431 25236195 SGTC_1197 1601-0112 267 µM 0.204104822972144 0.407383631725791 no 1345 0.419135792742421 469 7350313 SGTC_2576 guaiol 23.12 µM 0.20395022080203 0.407442783264706 no 1346 0.419196199623525 423 227829 SGTC_554 4483-2211 187 µM 0.203535906918228 0.407601312165938 no 1347 0.419358091664913 441 747107 SGTC_1376 2910-0861 41.3 µM 0.203464258151848 0.407628728665352 no 1348 0.419386089614028 435 1112859 SGTC_3180 9109287 49.47 µM 0.202316472367202 0.40806799206819 no 1349 0.419834661578591 441 18891271 SGTC_2839 9003951 25.97 µM 0.202184515227821 0.408118500147548 no 1350 0.419886239102951 473 2990634 SGTC_1182 1222-0449 220 µM 0.201652555939947 0.408322129023393 no 1351 0.420094177707947 470 658318 SGTC_3206 9114350 49.47 µM 0.200990676478986 0.408575524647511 no 1352 0.42035293220101 468 17087243 SGTC_1686 st019653 115.5 µM 0.20083716194101 0.408634302010578 no 1353 0.420412951942736 476 97252 SGTC_2670 beta-carotene 100 µM 0.200209134324487 0.408874781453521 no 1354 0.420658511822129 441 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2362 9071156 126 µM 0.199655164681352 0.409086931675211 no 1355 0.420875140540256 437 653133 SGTC_1671 st016596 74.5 µM 0.198270750983075 0.409617228080316 no 1356 0.421416617364993 452 2829167 SGTC_73 0327-0325 16.231 µM 0.197734688984998 0.409822609839981 no 1357 0.421626323824117 454 53298 SGTC_3134 9127454 49.47 µM 0.197596208759427 0.409875669877167 no 1358 0.421680500646786 474 24262820 SGTC_2235 salicylic acid 500 µM 0.19723183449938 0.410015291279577 no 1359 0.421823059773772 442 338 A COX inhibitor and kinase inhibitor. SGTC_3260 9137109 49.47 µM 0.196190719309122 0.410414289965323 no 1360 0.422230445911129 460 17478346 SGTC_215 1287-0124 461.5 µM 0.195749029570868 0.410583591905455 no 1361 0.422403303323565 463 5560863 SGTC_2063 5246145 200 µM 0.195704567354147 0.410600635424568 no 1362 0.422420704655355 457 711240 SGTC_1046 2001-0062 216 µM 0.195384799574712 0.410723215666512 no 1363 0.422545857737374 463 739778 SGTC_7 0192-1582 4.227 µM 0.194698161394767 0.410986461988535 no 1364 0.422814625681238 480 252616 SGTC_1179 1021-1431 9.29 µM 0.193619870549134 0.411399942682341 no 1365 0.42323676908458 472 2840958 SGTC_2652 actinonin 100 µM 0.19218198480781 0.411951466463902 no 1366 0.42379982845619 465 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_177 1327-0068 8.361 µM 0.192009796543826 0.412017523676706 no 1367 0.423867265837719 435 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_865 0488-0499 301 µM 0.191921399832808 0.412051436598493 no 1368 0.423901887197777 470 9634651 SGTC_2196 6573537 42.6665 µM 0.191313554791084 0.412284650846416 no 1369 0.424139971020281 474 2903087 SGTC_651 3253-0966 34.4 µM 0.186343915333395 0.414192526352466 no 1370 0.426087535530009 445 781462 SGTC_3070 9117005 49.47 µM 0.185684526772805 0.414445822991614 no 1371 0.426346081570998 470 8779016 SGTC_3191 9110352 49.47 µM 0.18488289737345 0.41475380775224 no 1372 0.426660442826385 465 17122424 SGTC_1688 st021091 57.6 µM 0.184227152302356 0.415005782960577 no 1373 0.42691762978174 476 3656366 SGTC_518 1021-0119 62.6 µM 0.183867865072016 0.415143856743696 no 1374 0.427058557464696 447 1097762 SGTC_2409 alverine citrate 63.97 µM 0.183763452697228 0.415183984298572 no 1375 0.427099514171164 384 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2171 5739187 198.077 µM 0.183708805664424 0.415204986489572 no 1376 0.427120950281583 461 2262761 SGTC_2440 5628896 157.78 µM 0.182663205216792 0.41560688291326 no 1377 0.42753114396917 466 5522048 SGTC_404 fumagillin 50 µM 0.182121564775855 0.41581510746408 no 1378 0.427743662747297 445 12015870 A methionine aminopeptidase binder. SGTC_986 1493-0483 84 µM 0.181520403559369 0.416046241449525 no 1379 0.427979559722207 476 40079 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.180884158376923 0.416290896121016 no 1380 0.428229251760881 465 6708514 SGTC_3195 9113082 49.47 µM 0.180301610856054 0.416514930937509 no 1381 0.428457895557925 490 17018038 SGTC_229 benomyl 22.8748 µM 0.179489053004599 0.41682746789465 no 1382 0.428776856095481 448 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1169 aniline yellow 25.8 µM 0.178606417366069 0.417167018683182 no 1383 0.429123377595107 476 6051 A DNA damaging agent. SGTC_114 0364-0001 490.298 µM 0.178319026728234 0.417277591488268 no 1384 0.429236218554643 423 4003655 SGTC_3097 9117246 49.47 µM 0.177369448278863 0.417642985818212 no 1385 0.429609101776546 467 16423892 SGTC_2902 5787006 60.46 µM 0.17711613704011 0.41774047108995 no 1386 0.429708583394786 446 591003 SGTC_2418 pentamidine 31.67 µM 0.176636981081672 0.417924885133016 no 1387 0.429896772048165 469 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2617 dihydrotanshinone i 20.83 µM 0.174431153207395 0.418774080227036 no 1388 0.430763316437834 458 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2212 7123476 200 µM 0.17191378515067 0.419743673853511 no 1389 0.431752654476238 478 1085715 SGTC_1616 st002734 56.1 µM 0.17147369503255 0.419913229906863 no 1390 0.43192565620869 458 4026101 SGTC_3015 9080845 49.47 µM 0.171230292518419 0.420007013381818 no 1391 0.432021344622301 478 5296973 SGTC_2780 5215298 71.43 µM 0.169270083672831 0.420762450919681 no 1392 0.432792103086504 465 2834131 SGTC_566 0958-0068 16.5 µM 0.168940746267313 0.420889401743043 no 1393 0.432921624460238 449 6815365 SGTC_1133 3473-0247 50 µM 0.166823842589818 0.421705607730903 no 1394 0.433754328948731 466 711311 SGTC_2585 alliin 100 µM 0.166704515614219 0.421751626200673 no 1395 0.433801276156888 483 87310 A garlic compound which reacts with lipids. SGTC_2344 7990960 76.95 µM 0.166056222125956 0.422001659359253 no 1396 0.434056352719084 470 140813 SGTC_1127 asiatic acid 681.4 nM 0.165784686546636 0.422106394267689 no 1397 0.434163198857751 441 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1314 1222-0010 41.1 µM 0.164433929451341 0.422627481084317 no 1398 0.434694777620638 458 3526027 SGTC_477 mead ethanolamide 10 µM 0.164365575607716 0.422653853819938 no 1399 0.434721680830988 458 16061185 SGTC_203 k066-0004 30.888 µM 0.163882043857207 0.422840423157409 no 1400 0.434912001451367 484 6795412 SGTC_574 1315-0397 40 µM 0.163020774441301 0.423172784333588 no 1401 0.435251038917581 479 6794277 SGTC_2180 6301957 200 µM 0.162701817486856 0.423295882713153 no 1402 0.435376607956276 466 845462 SGTC_1946 st076057 65.1 µM 0.162073042209255 0.423538574424437 no 1403 0.435624167351921 484 953009 SGTC_2829 7992743 58.44 µM 0.161529415875053 0.423748424135116 no 1404 0.435838222516696 489 16462845 SGTC_2110 5483698 200 µM 0.160828023842364 0.424019206235395 no 1405 0.436114426354377 456 2848765 YHR062C RPP1 SGTC_884 0851-0618 334 µM 0.16055225832812 0.424125679160791 no 1406 0.436223029646531 487 9642473 SGTC_3244 9134489 49.47 µM 0.159207113140913 0.42464511829005 no 1407 0.436752849933822 481 16584271 SGTC_1431 4049-0260 9.09 µM 0.159127324226838 0.424675933571394 no 1408 0.436784280439454 479 3854841 SGTC_2026 5148700 152 µM 0.157037059084895 0.425483378450622 no 1409 0.437607820750027 451 79838 SGTC_2474 5321570 43.32 µM 0.156851815528115 0.425554950990853 no 1410 0.437680817664266 495 2841384 SGTC_2396 5342950 42.78 µM 0.155910578627859 0.425918654477291 no 1411 0.438051753371978 472 1886677 SGTC_1045 1348-1485 165 µM 0.155876060081191 0.425931993993905 no 1412 0.438065357956966 446 6810614 SGTC_3241 9133421 49.47 µM 0.154683700072974 0.426392827376564 no 1413 0.438535340386836 487 17018221 SGTC_1819 st053448 58.6 µM 0.152152650335992 0.427371381280154 no 1414 0.439533269304891 492 2857616 SGTC_1113 artemisinin 1.17947 µM 0.151757938009695 0.42752402531814 no 1415 0.439688929199809 484 2240 An anti-malaria and mitochondrial poison. SGTC_2905 7799065 20.05 µM 0.15141006405198 0.427658564912639 no 1416 0.439826125511317 484 1296806 SGTC_1984 st072354 53.1 µM 0.148861079051752 0.428644635697739 no 1417 0.440831626685569 479 5762938 SGTC_355 1311-2252 105 µM 0.147989466106584 0.428981920323786 no 1418 0.441175540766079 491 5338538 SGTC_2328 6201408 200 µM 0.147091587659066 0.429329423038492 no 1419 0.441529864865873 468 2890418 SGTC_2769 toremifene 3.73 µM 0.146833377722695 0.429429367267982 no 1420 0.441631769298527 478 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_136 0097-0015 404.482 µM 0.146796591486292 0.429443606329424 no 1421 0.441646287569326 452 4861337 SGTC_1377 2944-0135 198 µM 0.145830675154252 0.429817521950448 no 1422 0.442027529745718 455 1894137 SGTC_2320 7373003 200 µM 0.145254412042405 0.43004062902185 no 1423 0.442255003413357 463 5415828 SGTC_2616 abietic acid 100 µM 0.144597813470026 0.430294866140778 no 1424 0.442514211844351 510 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_677 0929-0063 136 µM 0.142601725168726 0.431067935114598 no 1425 0.443302367460159 485 1539583 SGTC_776 4476-4378 112 µM 0.141895098227301 0.431341669521873 no 1426 0.44358143309474 480 2892008 SGTC_2792 7535235 81.82 µM 0.141837013931537 0.431364171788768 no 1427 0.443604373363064 463 1281891 SGTC_837 0091-0265 12.5 µM 0.14183517740611 0.431364883275338 no 1428 0.443605098697934 484 759367 SGTC_2151 5563267 85.4165 µM 0.139610674420723 0.432226838689785 no 1429 0.44448380312971 505 5310824 SGTC_589 1227-0070 34.1 µM 0.139188561309621 0.432390436576401 no 1430 0.444650573634867 483 2841384 SGTC_3314 9135860 59.4275 µM 0.137997851888608 0.432851980819215 no 1431 0.445121057624947 504 25252478 SGTC_3032 9089427 49.47 µM 0.137888543976364 0.432894355486866 no 1432 0.445164252250806 491 17173707 SGTC_3063 1327-0034 4 µM 0.137121599361722 0.433191693453193 no 1433 0.445467339952683 495 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1480 1070-0044 41.2 µM 0.136650430742319 0.433374380324209 no 1434 0.445653556196595 478 3124987 SGTC_2662 daunorubicin 22.37 µM 0.13640034131749 0.433471353634719 no 1435 0.44575240193401 472 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_876 0720-0963 56.8 µM 0.133095364779526 0.43475324731825 no 1436 0.447058980452234 499 765861 SGTC_3130 9127414 49.47 µM 0.132663796356614 0.434920689714716 no 1437 0.447229638022471 494 1494646 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.132486254319703 0.434989576884629 no 1438 0.44729984732419 467 165521 SGTC_2656 pseudo-anisatin 100 µM 0.132306463284435 0.435059338687796 no 1439 0.447370947679127 502 6708809 A neurotoxin. SGTC_3322 9139058 2.11 µM 0.131620160367199 0.435325653786991 no 1440 0.447642369295059 458 4908926 YPR165W RHO1 SGTC_1033 k072-0102 21.3 µM 0.130000393801443 0.435954309112866 no 1441 0.448283057563333 487 5965931 SGTC_1447 4239-0816 81.9 µM 0.129553554127142 0.436127762740248 no 1442 0.448459825943136 464 1341554 SGTC_1913 st060213 96.1 µM 0.128316941973922 0.436607853135099 no 1443 0.44894907909087 477 688959 SGTC_2703 st077852 53.4 µM 0.127455325757954 0.436942413965546 no 1444 0.449290014809527 473 6281836 SGTC_570 0987-0065 62.6 µM 0.126710882794941 0.437231513396469 no 1445 0.449584616023403 501 3104428 SGTC_746 1095-0025 46.6 µM 0.125611062796766 0.437658682410659 no 1446 0.45001990273846 508 6749286 SGTC_2236 dapsone 200 µM 0.125232423925204 0.437805762219437 no 1447 0.450169774358228 490 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_315 k915-0449 187 µM 0.124663778355096 0.438026665032464 no 1448 0.450394867162355 492 20970215 YNL149C PGA2 SGTC_670 4204-0025 119 µM 0.124310342295098 0.438163974739747 no 1449 0.450534779426237 496 719039 SGTC_577 r071-0003 38.6 µM 0.124031557361748 0.438272287780031 no 1450 0.450645144407804 498 4568517 YMR134W ERG29 SGTC_490 phenamil 164 µM 0.123046720840518 0.438654951728592 no 1451 0.451035050580231 503 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3309 9129340 25.759 µM 0.122277905824162 0.438953719147511 no 1452 0.451339464639166 483 17158987 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.122165788734062 0.438997291619841 no 1453 0.451383860051968 488 616764 SGTC_3305 9127027 53.8275 µM 0.121535756059384 0.439242157242535 no 1454 0.451633347680206 478 41905295 SGTC_957 1187-1561 14.1 µM 0.120011178609319 0.439834788579547 no 1455 0.452237146356439 501 1538454 SGTC_637 1181-0519 7.26 µM 0.119776398984777 0.439926063758454 no 1456 0.452330139104335 500 6252091 YGR060W ERG25 SGTC_2719 novobiocin 32.65 µM 0.119386604278036 0.440077611136632 no 1457 0.452484536813481 471 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_441 propafenone 146 µM 0.118100352863042 0.440577752000703 no 1458 0.452994071932773 504 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1696 st025591 34.7925 µM 0.116647623815862 0.44114273933538 no 1459 0.453569648475522 474 2787147 SGTC_628 1636-0253 16 µM 0.116599178161123 0.441161582621727 no 1460 0.453588844507823 491 4456143 SGTC_3177 9107506 49.47 µM 0.115925396759295 0.441423668540893 no 1461 0.4538558338437 507 8897194 SGTC_599 1935-0052 86.5 µM 0.115916280325918 0.441427214806038 no 1462 0.453859446420443 487 9557311 SGTC_649 1123-0311 367 µM 0.114543454462239 0.441961293371229 no 1463 0.454403500687113 496 693629 YIL048W NEO1 SGTC_1800 st050079 29.0735 µM 0.114033160489112 0.442159843007781 no 1464 0.454605753310128 496 3645560 SGTC_1645 Cervolide 78 µM 0.113452579637555 0.442385758145692 no 1465 0.454835878117684 485 23173 A fragrance. SGTC_2268 7933382 153.85 µM 0.113444252862702 0.442388998389864 no 1466 0.454839178711524 439 935025 YOR257W CDC31 SGTC_1776 st049249 45.9 µM 0.112282302500472 0.442841192287794 no 1467 0.455299786810378 500 1822314 SGTC_88 0180-0332 8.668 µM 0.111701805239724 0.443067131176416 no 1468 0.455529923957999 493 3101745 SGTC_2651 TUB2.036 5 µM 0.111605268375176 0.443104706677179 no 1469 0.455568197282362 476 15992207 YFL037W TUB2 SGTC_1531 st059297 52.4 µM 0.111027962949774 0.443329424668523 no 1470 0.455797086293497 495 7566702 SGTC_2779 methotrexate 400 µM 0.110971646154649 0.44335134713887 no 1471 0.455819415461229 502 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2407 paclitaxel 400 µM 0.109515099414783 0.443918397947199 no 1472 0.456396973100266 505 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2148 5546263 113.568 µM 0.109445690214958 0.443945422642239 no 1473 0.456424497913829 477 792097 SGTC_303 1348-1668 34.2 µM 0.108857421520039 0.444174477403266 no 1474 0.45665778929358 487 5380509 SGTC_780 0109-0199 192 µM 0.106807755218842 0.444972703179923 no 1475 0.457470747449268 508 610414 SGTC_811 0416-0114 265 µM 0.104931073625934 0.445703757285062 no 1476 0.458215250940341 506 6612453 SGTC_3270 9137563 49.47 µM 0.104174255079083 0.445998625428531 no 1477 0.458515532130969 508 17015724 SGTC_1059 3448-6867 171 µM 0.103189468505354 0.446382358116201 no 1478 0.458906299103393 501 3934407 SGTC_799 1310-0557 151 µM 0.103017227466193 0.446449478860711 no 1479 0.458974649078683 509 5354492 SGTC_2303 7774051 200 µM 0.102675630303001 0.446582600661972 no 1480 0.459110207801536 500 2953184 SGTC_697 0508-1955 564 µM 0.101699953725665 0.446962858887691 no 1481 0.459497419439215 503 6243113 SGTC_1938 st074717 56.4 µM 0.101581881177041 0.447008879559875 no 1482 0.459544280884845 514 17250979 SGTC_1224 0823-0416 294 µM 0.10130810895431 0.447115589425108 no 1483 0.459652939650021 491 3598164 SGTC_3055 9094636 49.47 µM 0.100958313657811 0.447251936836449 no 1484 0.459791775960227 511 25236176 SGTC_3078 9116413 49.47 µM 0.0996545795364967 0.447760176771475 no 1485 0.460309280621335 503 17177322 SGTC_681 1642-0006 26.6 µM 0.0994968443532285 0.447821673147994 no 1486 0.460371896655128 507 4446530 SGTC_2930 9013230 14.89 µM 0.0991962458929799 0.447938871247038 no 1487 0.460491227751264 488 2995857 SGTC_1512 0259-0544 12.2 µM 0.0988093637515338 0.448089716536436 no 1488 0.460644816840646 479 18476 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0985704868084759 0.44818285837073 no 1489 0.460739651993431 512 5282309 SGTC_3008 9078912 71.4286 µM 0.0983432297032001 0.448271472101331 no 1490 0.460829876094485 502 16648731 SGTC_3056 9094900 49.47 µM 0.0960617852933652 0.44916121166595 no 1491 0.461735750909014 478 25236784 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0951769032095059 0.449506375532623 no 1492 0.462087157630226 488 688761 SGTC_1153 4055-0057 267 µM 0.0944682337245377 0.449782832133059 no 1493 0.462368607692577 504 882706 SGTC_58 0957-0393 9 µM 0.094464245531372 0.449784388022391 no 1494 0.462370191668066 492 6997992 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0944440959501097 0.44979224886671 no 1495 0.462378194409633 482 5282362 SGTC_2211 7117706 200 µM 0.0942728625686605 0.44985905199037 no 1496 0.462446203211368 515 822771 SGTC_699 0375-0592 111 µM 0.0929709653073297 0.450367006323343 no 1497 0.462963313810636 515 762578 SGTC_110 0850-0284 111.64 µM 0.0915978632940192 0.450902830327663 no 1498 0.463508774579496 499 3906265 SGTC_46 0329-0187a 2.197 µM 0.0895979962505457 0.451683395938922 no 1499 0.464303338382133 498 46494817 SGTC_3197 9113331 49.47 µM 0.0888708549020524 0.451967252045707 no 1500 0.464592273148093 479 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1664 st014217 9.02 µM 0.0888656944176616 0.451969266645683 no 1501 0.464594323770029 512 3982782 SGTC_2248 tofa 1.1 µM 0.0886188452258666 0.452065635472331 no 1502 0.464692415342925 512 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_352 k048-0007 5.11 µM 0.0884612991877564 0.452127142221793 no 1503 0.464755021242407 517 6811911 SGTC_1574 spiramycin 23.7 µM 0.0876442194407487 0.45244615257965 no 1504 0.465079727676572 506 6419898 An antibiotic and protein synthesis inhibitor. SGTC_903 1134-0042 114 µM 0.0870114592887218 0.452693220613092 no 1505 0.465331201730285 493 701009 SGTC_863 0466-0191 129 µM 0.0864998835178361 0.452892984291886 no 1506 0.465534524332641 519 765160 YPR165W RHO1 SGTC_1026 k007-1105 30.6 µM 0.0863109764246518 0.452966753069449 no 1507 0.465609606557158 503 7066794 SGTC_3335 9143315 29.6265 µM 0.0858363916105375 0.453152086996288 no 1508 0.465798238450982 500 4899691 SGTC_1233 0325-0408 14.2 µM 0.0838283888033337 0.453936360754801 no 1509 0.466596438226683 504 12874 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0824015361079987 0.454493761735914 no 1510 0.467163707284182 496 107982 A Capsaicinoid. SGTC_1039 k821-0043 94 µM 0.0816592521593806 0.454783770977979 no 1511 0.467458841080764 498 15992768 SGTC_1023 4482-3888 16 µM 0.0815630724585128 0.454821350012133 no 1512 0.46749708366255 509 3303168 SGTC_2314 7727897 200 µM 0.0808363412050025 0.455105309237716 no 1513 0.467786053262728 513 900724 SGTC_2197 6588183 93.1375 µM 0.0803721134552091 0.455286711213374 no 1514 0.46797065268806 501 884136 SGTC_1637 st007924 17.4 µM 0.0799867328976942 0.455437309886586 no 1515 0.468123903886945 514 683336 SGTC_377 3970-0964 33.1 µM 0.0788798094437678 0.455869907992464 no 1516 0.468564111461837 510 16481235 SGTC_772 k072-0172 35.3 µM 0.0784679670201727 0.456030874014988 no 1517 0.468727905124078 501 5861980 SGTC_2943 9068529 45.32 µM 0.0783534304997649 0.456075641177778 no 1518 0.468773458333251 528 3270634 SGTC_1159 4092-0538 61.2 µM 0.0781957867018527 0.456137257943958 no 1519 0.468836156741024 514 717301 SGTC_2653 dihydrofissinolide 100 µM 0.0762302991372339 0.45690557789379 no 1520 0.469617938794579 513 6857746 SGTC_897 1000-0139 31.4 µM 0.0760939606665718 0.45695887936416 no 1521 0.469672172450831 514 6151020 SGTC_1501 4491-0275 38.4 µM 0.0747202209686483 0.45749598539528 no 1522 0.47021865932011 518 5104718 SGTC_3324 9138759 60.749 µM 0.0744137170960866 0.457615833194279 no 1523 0.470340597200332 502 45595710 SGTC_346 4513-0042 7.16 µM 0.0730429145682451 0.458151885394337 no 1524 0.470885983903804 484 2827372 SGTC_313 3474-0040 5.03 µM 0.0729215978171683 0.458199329979325 no 1525 0.47093425356178 513 1043375 YIL048W NEO1 SGTC_1829 berberine 14.4 µM 0.0725848558248138 0.458331026239711 no 1526 0.47106823911494 508 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1816 st051957 91.6 µM 0.0712750542633978 0.458843319256454 no 1527 0.471589424269343 524 674121 SGTC_561 1550-0330 72.9 µM 0.0712502162194127 0.458853034640393 no 1528 0.471599308086555 510 6812934 SGTC_2593 nobiletin 86.24 µM 0.070498920179564 0.459146915161458 no 1529 0.471898279992666 507 72344 An anti-infammatory. SGTC_1817 st052116 64.4 µM 0.0702163473330864 0.459257453482322 no 1530 0.472010731574596 483 4361398 SGTC_3158 9100007 49.47 µM 0.0699329774106893 0.45936830677073 no 1531 0.472123502598374 511 19297233 SGTC_2389 9091542 195.52 µM 0.0688924254180435 0.459775393979318 no 1532 0.472537623918148 515 3626624 YOL127W RPL25 SGTC_356 1634-0012 32.5 µM 0.0685142531677411 0.459923353891697 no 1533 0.472688137175181 518 735457 SGTC_1594 piperine 70.1 µM 0.0678384933218832 0.460187758772673 no 1534 0.472957100543813 518 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_277 nystatin 15.5 µM 0.0675505934588904 0.460300410845939 no 1535 0.473071693107111 499 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0670694093410494 0.460488700047325 no 1536 0.47326322342562 517 4620898 SGTC_1520 flindersine 88 µM 0.0668295375245005 0.460582566126173 no 1537 0.473358704211413 512 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_508 roscovitine 141 µM 0.0666715916560581 0.460644374334051 no 1538 0.473421575274802 522 160355 A CDKinase inhibitor. SGTC_1718 roemerine 11.9335 µM 0.0658260147422059 0.460975286073594 no 1539 0.473758172190248 508 235224 An aporphine alkaloid with mutagenic activity. SGTC_1527 coumarin 137 µM 0.0649777660794147 0.461307270539481 no 1540 0.474095851467297 525 323 A hepatotoxic, DNA x-linker. SGTC_1287 0971-0001 34.6 µM 0.0642086510890828 0.461608307273201 no 1541 0.474402044519192 507 4665869 SGTC_1336 1486-0901 104 µM 0.0641709552715057 0.461623062234353 no 1542 0.474417052024803 510 5006114 SGTC_386 1509-0011 3.07 µM 0.064110923119067 0.461646560230795 no 1543 0.474440952174665 517 3107280 SGTC_2669 eugenol 100 µM 0.062632744541195 0.46222519612639 no 1544 0.475029477111684 525 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_193 1273-0060 1.558 µM 0.0623948736193351 0.462318318664506 no 1545 0.475124188633351 526 2847393 YHR072W ERG7 SGTC_708 3448-5400 146 µM 0.0622590940870128 0.462371475035696 no 1546 0.475178251719358 530 3462195 SGTC_1691 st019933 84.6 µM 0.0617442569739275 0.462573034873779 no 1547 0.475383247606717 526 6176082 SGTC_2848 9016370 25.97 µM 0.061617379748444 0.462622709058736 no 1548 0.475433768101682 530 7894410 SGTC_1148 3909-7663 27.7 µM 0.0613887989307165 0.462712203074337 no 1549 0.4755247863471 509 4084526 SGTC_2130 NSC 7 2.4545 µM 0.0613750965133737 0.462717567908011 no 1550 0.47553024253228 528 21448 SGTC_2738 aclarubicin 5.55 µM 0.0584731682728211 0.463853895510512 no 1551 0.476685867266214 513 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_26 0302-0163 425.158 µM 0.057882383345971 0.464085269582106 no 1552 0.476921157823105 520 3100915 SGTC_3073 9114972 49.47 µM 0.0567395333331488 0.464532887955293 no 1553 0.477376340839716 534 41905075 SGTC_2833 9001315 45.46 µM 0.0567105052522559 0.464544257927751 no 1554 0.477387902751988 528 2989378 SGTC_1434 4073-0095 163 µM 0.0564306671994431 0.464653868825848 no 1555 0.477499363489724 527 24133745 SGTC_607 4491-0986 66.8 µM 0.0563195338214156 0.46469739985254 no 1556 0.477543628895948 523 698981 YDR232W HEM1 SGTC_2126 5251174 33.877 µM 0.0554325316057763 0.465044854380351 no 1557 0.477896939599137 507 790722 SGTC_317 4495-0002 170 µM 0.0547282084450443 0.465320769274004 no 1558 0.478177497972663 512 15991618 SGTC_1333 1482-0047 286 µM 0.0537285116003806 0.465712423850867 no 1559 0.478575733316 533 3811116 SGTC_3001 9076041 71.4286 µM 0.0530747126694584 0.465968582831793 no 1560 0.478836189706967 503 16004211 SGTC_1634 st006576 41 µM 0.0530311922423164 0.465985634674097 no 1561 0.478853527428724 525 3915356 SGTC_539 4859-0462 2.54 µM 0.0501233422264888 0.467125106245558 no 1562 0.480012049353798 491 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1358 1509-0022 2.48 µM 0.0497761601496042 0.46726117137934 no 1563 0.4801503822861 510 3258434 SGTC_263 alizarin 107.927 µM 0.0476812063987686 0.468082291400639 no 1564 0.480985156093001 528 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_842 0271-0008 11.1 µM 0.0471263432023626 0.468299793690778 no 1565 0.481206265909528 526 1221709 SGTC_2556 citropten 84.59 µM 0.0456579213372339 0.468875449744587 no 1566 0.481791451358703 524 2775 A potential DNA crosslinker. SGTC_820 1582-0060 59.9 µM 0.0455290423695132 0.468925976467754 no 1567 0.481842813215562 513 3848840 SGTC_810 3825-7150 143 µM 0.0452785179243676 0.469024195470981 no 1568 0.481942655043561 513 22330411 YGL099W LSG1 SGTC_3289 9119912 71.43 µM 0.0443136589377105 0.469402489440454 no 1569 0.482327192056241 527 17014829 SGTC_2602 kawain 100 µM 0.0438357960411455 0.469589856240722 no 1570 0.482517646691403 523 5369129 SGTC_956 1185-0240 191 µM 0.0436072922843899 0.469679453396253 no 1571 0.482608719413296 516 1416193 SGTC_1014 4130-3005 69.3 µM 0.043342779027475 0.469783171924953 no 1572 0.482714145256235 509 743608 SGTC_1411 3909-8223 150 µM 0.0431774207656122 0.469848011742185 no 1573 0.482780051959272 528 X1411 SGTC_2972 9093619 59.92 µM 0.0428247176959621 0.469986315348594 no 1574 0.482920630094405 507 25236256 SGTC_922 1866-0035 480 µM 0.0427729719594286 0.470006606438077 no 1575 0.482941254758361 524 3156169 SGTC_694 1315-0438 43.2 µM 0.0405680308917997 0.470871303111284 no 1576 0.483820135409137 531 6793154 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0396943948937554 0.471213949190435 no 1577 0.484168385191813 527 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1271 0832-2808 169 µM 0.0391997493759435 0.471407962047565 no 1578 0.484365566726691 527 3663794 SGTC_1699 st031318 29.054 µM 0.0385193186836698 0.471674855767477 no 1579 0.484636814415556 536 5340658 SGTC_3144 9087057 49.47 µM 0.0382486397926553 0.471781031029648 no 1580 0.484744720149609 534 17249618 SGTC_2710 st078562 53.7235 µM 0.0337153420169779 0.473559533845187 no 1581 0.486552072383809 529 17250908 SGTC_1515 3460-0031 42.1 µM 0.0322962436348113 0.474116384353508 no 1582 0.487117902394483 524 2876596 SGTC_1826 st055655 41.6 µM 0.0314860511098211 0.474434324539249 no 1583 0.487440958116209 536 676168 SGTC_585 0kpi-0023 191 µM 0.0308562633617468 0.474681480553485 no 1584 0.487692085040193 530 64601 SGTC_960 1222-0186 7.7 µM 0.0275446281755067 0.475981267879841 no 1585 0.489012672599947 531 3126296 SGTC_874 0599-0792 117 µM 0.0261378945606674 0.476533476457072 no 1586 0.489573675945166 531 765305 SGTC_2360 9040895 200 µM 0.025300285848843 0.476862298430924 no 1587 0.489907722965403 527 4914414 SGTC_2095 5432005 200 µM 0.0248246421157574 0.477049030010394 no 1588 0.49009741777357 539 783734 SGTC_1815 st051655 58.2 µM 0.0248096641636723 0.477054910242775 no 1589 0.490103391272135 536 5984156 SGTC_408 cantharidin 100 µM 0.0241424015664433 0.477316877616503 no 1590 0.490369510804487 537 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_648 0375-0473 33.3 µM 0.0240206350024449 0.47736468424471 no 1591 0.490418074551601 529 1713139 SGTC_3050 9093513 49.47 µM 0.0225194267507535 0.477954098410415 no 1592 0.491016807811401 539 25236664 SGTC_371 0195-0006 7.36 µM 0.0217196348849894 0.478268137676302 no 1593 0.49133580054676 539 3928593 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0212617048216771 0.478447950569539 no 1594 0.49151844602671 540 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1387 3342-1166 1.8 µM 0.0201858003118034 0.478870437305906 no 1595 0.491947577644366 534 3418228 SGTC_472 calcifediol 10 µM 0.0201113061140006 0.478899690610136 no 1596 0.491977290497718 539 5283731 A vitamin D metabolite. SGTC_1042 0350-0096 82 µM 0.0200919499675201 0.478907291640079 no 1597 0.49198501092296 533 3122515 SGTC_142 0335-0849 62.6745 µM 0.0186582510160484 0.479470316820307 no 1598 0.492556866657273 540 3889043 YPR107C YTH1 SGTC_3030 9087619 49.47 µM 0.0178239189624891 0.479797984697783 no 1599 0.492889661608448 540 25236973 SGTC_2203 7227154 166.4 µM 0.0171315448685005 0.480069911690247 no 1600 0.493165836717899 535 896304 SGTC_3076 9116187 49.47 µM 0.016028784147314 0.480503035391878 no 1601 0.49360571410675 542 27241210 SGTC_128 0906-2981 13.371 µM 0.0146015703186561 0.481063626396447 no 1602 0.494175023226895 539 6740226 SGTC_1914 st062367 72.6 µM 0.0129827783817543 0.481699512054743 no 1603 0.49482076628234 541 978205 SGTC_3256 9138902 49.47 µM 0.0127379476632299 0.481795689312379 no 1604 0.494918431530547 542 17228773 SGTC_1201 1889-3372 45.9 µM 0.012345294512587 0.481949938111291 no 1605 0.495075065153752 532 5392199 SGTC_2091 4-phenylthiadiazole 200 µM 0.0118195221547517 0.482156485326006 no 1606 0.495284802664963 543 270010 SGTC_360 0957-0399 1.01 µM 0.0117410763224695 0.482187302816724 no 1607 0.495316095852735 538 6752301 YPR165W RHO1 SGTC_3109 9122853 49.47 µM 0.011507703324382 0.482278984162999 no 1608 0.495409191918482 543 1234709 SGTC_123 0083-0120 66.675 µM 0.0111833554269328 0.482406406851598 no 1609 0.495538579680036 542 16001701 SGTC_1612 st002233 45.4 µM 0.011078284463623 0.482447685213353 no 1610 0.495580494333131 543 1035021 SGTC_2598 perillyl alcohol 100 µM 0.0109547232785009 0.482496227916577 no 1611 0.495629785122923 540 10819 An apoptosis inducer. SGTC_2861 9024595 19.48 µM 0.0104560702809471 0.482692133202945 no 1612 0.495828707485708 546 16482810 SGTC_2655 perillic acid 100 µM 0.0104111662398694 0.482709774812833 no 1613 0.495846620631211 545 5702197 An apoptosis inducer. SGTC_1621 st003705 32.4 µM 0.00945325870280175 0.483086119352719 no 1614 0.496228751585 543 24207032 SGTC_2183 6420625 130.508 µM 0.00922662352158155 0.483175162431994 no 1615 0.496319161997282 537 2897619 SGTC_1561 5-methoxyflavone 52.9 µM 0.00919564669639257 0.483187333034469 no 1616 0.496331519438317 545 94525 SGTC_1920 st075728 45.7 µM 0.0084800352950997 0.483468496653277 no 1617 0.496616995927404 544 3400306 SGTC_725 1497-0963 19 µM 0.00700471262658709 0.484048176510951 no 1618 0.497205546823317 544 3549977 SGTC_212 3807-4682 38.772 µM 0.00613577990768894 0.484389611099098 no 1619 0.497552193330682 541 3125501 YBL034C STU1 SGTC_2892 9047358 58.44 µM 0.0041058377658273 0.485187291776902 no 1620 0.498362012320917 544 6466771 SGTC_3120 9124077 49.47 µM 0.00155792354227434 0.486188596904006 no 1621 0.499378478680772 546 18774327 YGL155W CDC43 SGTC_3024 9090631 49.47 µM 0.000956945613055569 0.4864247882219 no 1622 0.499618233993174 548 25236383 SGTC_2468 5987765 72.9 µM 0.000159043803254875 0.486738380260244 no 1623 0.499936550702713 548 26772094 SGTC_1346 1488-2224 62.4 µM -0.000708832012132105 0.487079482845234 no 1624 0.499717216964339 548 3722427 SGTC_1162 k048-0130 20.1 µM -0.00113308936477753 0.487246232829377 no 1625 0.499547962841645 550 6797406 SGTC_2953 9074162 66.49 µM -0.00118067739758771 0.487264936955306 no 1626 0.499528977976022 549 16451992 SGTC_806 3966-4455 5.86 µM -0.00122313414929882 0.487281624292623 no 1627 0.499512040194911 551 714982 SGTC_2103 5378138 10 µM -0.00310185179242179 0.488020063348911 no 1628 0.498762542156828 549 244142 SGTC_3288 9119690 36.221 µM -0.00361037519104926 0.488219948099294 no 1629 0.498559671817246 551 17595618 YKL019W RAM2 SGTC_143 4032-1194 15.74 µM -0.00467005551127214 0.488636484962846 no 1630 0.498136924176834 551 1806963 SGTC_899 1083-0020 478 µM -0.00494103264924084 0.488743002082195 no 1631 0.498028821188039 550 767123 SGTC_728 3030-5151 22.5 µM -0.00538280151646999 0.488916656631325 no 1632 0.497852583258149 554 3125388 SGTC_1267 0828-0272 9.49 µM -0.00611753099907254 0.48920547545722 no 1633 0.497559473455266 553 745334 SGTC_522 1273-0010 11.6 µM -0.00754279289072695 0.489765755445193 no 1634 0.496990889536855 549 5705015 SGTC_2067 5224629 34.075 µM -0.00765235998974146 0.48980882785509 no 1635 0.496947179850088 550 2835000 SGTC_1570 verbenone 133 µM -0.007872211007234 0.489895254824956 no 1636 0.496859474626292 552 29025 A natural terpanoid with antifungal properties. SGTC_3290 9121031 71.43 µM -0.00885052131023422 0.490279850031365 no 1637 0.496469198941438 551 17014854 SGTC_3234 9132280 49.47 µM -0.00962066895711651 0.490582618313984 no 1638 0.496161967593653 554 17612295 SGTC_2076 5212012 200 µM -0.00971317136994831 0.490618984172594 no 1639 0.496125066194395 551 604802 SGTC_1245 0418-0076 17.2 µM -0.0102970196619199 0.490848516668964 no 1640 0.495892156086363 556 6790114 SGTC_3088 9117578 49.47 µM -0.010297892751832 0.490848859915396 no 1641 0.495891807792349 552 678341 SGTC_966 1300-0360 30.2 µM -0.0103659940086619 0.490875633253757 no 1642 0.495864640771722 553 70588 SGTC_524 r073-0010 27.8 µM -0.0125711392645568 0.491742585926804 no 1643 0.494984973125312 567 2772106 SGTC_266 formosanin C 406 nM -0.0131684250493157 0.491977415668282 no 1644 0.494746710308537 555 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2471 5466956 24.79 µM -0.0144481137026555 0.492480549162809 no 1645 0.494236237101647 557 724419 SGTC_2477 5967686 25.23 µM -0.0144603272726538 0.492485351214871 no 1646 0.494231365101147 559 776118 SGTC_1961 st076550 68.7 µM -0.0144979880503844 0.492500158441512 no 1647 0.494216342199427 556 1579337 SGTC_2104 5389443 200 µM -0.0145921629527082 0.492537185579782 no 1648 0.494178775823118 558 2244536 SGTC_514 4466-0038 2.65 nM -0.0150620995953041 0.492721953479937 no 1649 0.493991318835764 562 5722064 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0150993281898773 0.492736590944299 no 1650 0.49397646846414 557 5393153 SGTC_183 3914-0051 30.55 µM -0.0161427780052458 0.493146856362364 no 1651 0.493560243020395 555 1596232 SGTC_364 0083-0097 67.7 µM -0.0171588875594796 0.493546379059336 no 1652 0.493154930165562 558 5207356 SGTC_1456 k015-0012 13 µM -0.0176222944382747 0.493728587536555 no 1653 0.492970085523877 565 2989616 SGTC_3302 9125395 16.351 µM -0.0178993834512026 0.493837537705854 no 1654 0.492859560435339 567 17599668 SGTC_1682 st012968 530 nM -0.0179187489612249 0.493845152155671 no 1655 0.492851835953464 560 24207270 SGTC_2010 4012422 159 µM -0.0182910307479047 0.493991532465705 no 1656 0.492703341348689 563 952393 SGTC_1214 0358-0031 63.7 µM -0.018863828971799 0.494216756933448 no 1657 0.492474867351139 573 4301366 SGTC_2096 5468907 200 µM -0.0196254558867044 0.494516231753515 no 1658 0.492171078440505 556 759785 SGTC_2145 5634607 200 µM -0.0198457268933935 0.494602843798473 no 1659 0.492083220134756 562 308662 SGTC_1726 st035556 14.5795 µM -0.0207453861661652 0.494956598488378 no 1660 0.491724381937054 570 5919439 SGTC_613 3914-0030 117 µM -0.0217853247118935 0.495365517263185 no 1661 0.491309600296745 555 1145395 SGTC_287 k060-0039 29.6 µM -0.0218753445946649 0.495400914609381 no 1662 0.491273696115773 554 5861974 SGTC_1683 st010134 710 nM -0.0220208576225316 0.495458132878802 no 1663 0.491215658797186 577 3818134 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0221792860724615 0.495520429824438 no 1664 0.491152470423059 564 16486 A toxic proline analog. SGTC_998 3996-0085 177 µM -0.0226912917345158 0.495721760494721 no 1665 0.490948261118937 553 715391 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0239700884715732 0.49622461310555 no 1666 0.490438233895409 553 5357218 A potent inhibitor of glutathione S-transferases. SGTC_688 0527-0193 473 µM -0.0255694314494955 0.496853520300049 no 1667 0.489800384132123 557 4007154 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0255891219322784 0.496861263210433 no 1668 0.48979253133548 566 77254 SGTC_652 0437-0092 114 µM -0.0266978050808044 0.497297233735385 no 1669 0.489350381900722 560 3091274 SGTC_1210 3013-0140 750 nM -0.0270390147214943 0.497431409214962 no 1670 0.489214308074722 567 905973 SGTC_1910 st062352 60.4 µM -0.0273926049683606 0.497570453485186 no 1671 0.489073298208741 557 2245730 SGTC_2920 7982904 15.77 µM -0.0295290371929043 0.498410580351789 no 1672 0.488221330351799 559 6456808 SGTC_1859 st055998 20 µM -0.0296962953449293 0.498476353000424 no 1673 0.48815463325338 577 676301 SGTC_1181 1222-0449 220 µM -0.0306269391203332 0.498842320359828 no 1674 0.487783528956248 572 658318 SGTC_167 3672-0051 66.205 µM -0.031331391810985 0.499119340758146 no 1675 0.487502627823185 566 3237971 SGTC_1878 temozolomide 1 mM -0.0319290612682429 0.499354369840428 no 1676 0.487264311454683 560 5394 DNA alkylating agent. SGTC_2239 6685329 187.64 µM -0.0325297848790008 0.499590600171589 no 1677 0.487024781847406 577 805680 SGTC_586 0957-0265 8.15 µM -0.0334491913973859 0.499952150562433 no 1678 0.48665819126296 560 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_797 k781-0471 270 µM -0.0336925493208719 0.499952150562433 no 1679 0.48656116019083 570 23738129 SGTC_3319 9138450 16.7555 µM -0.0342163357783955 0.499746175059119 no 1680 0.486352320050447 567 2029690 SGTC_502 l-744,832 89.3 µM -0.0342552494269813 0.49973087253043 no 1681 0.486336804846011 566 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1899 st063254 59.6 µM -0.0366978095862055 0.498770354014986 no 1682 0.485362977582641 566 3093813 SGTC_1615 st002656 86.5 µM -0.0371452701937076 0.498594394085727 no 1683 0.485184588260601 561 1584458 SGTC_2156 5649887 115 µM -0.0372267174804997 0.498562365688437 no 1684 0.485152117951988 569 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1482 3346-2049 8.48 µM -0.0374429202470241 0.498477345982213 no 1685 0.485065925619647 571 3826804 SGTC_103 0844-0104 51.839 µM -0.0390962714296742 0.497827183735992 no 1686 0.484406816833144 566 5375804 SGTC_871 0574-0004 149 µM -0.0391340544551554 0.497812326035869 no 1687 0.484391755113393 564 9551173 SGTC_3221 9128209 49.47 µM -0.0404930946167372 0.497277902742475 no 1688 0.483850006112811 564 16460723 SGTC_3079 9117512 49.47 µM -0.0413350216600973 0.496946829247662 no 1689 0.483514406835596 562 7185044 SGTC_580 1123-0028 41 µM -0.0417834313831717 0.496770500591926 no 1690 0.483335671659238 568 1677248 YPR107C YTH1 SGTC_170 4197-0004 226 µM -0.0421611310830312 0.496621977805645 no 1691 0.483185123946857 572 218692 SGTC_146 3448-8650 53.125 µM -0.0424696457458036 0.496500660985772 no 1692 0.483062154547556 573 2891488 YIL048W NEO1 SGTC_12 0849-0099 9.267 µM -0.0427971962586363 0.496371859077756 no 1693 0.482931599502519 563 6071388 SGTC_2499 avocadenofuran 51.48 µM -0.0431979385182917 0.49621427666924 no 1694 0.482771874190275 596 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2739 tacrine 100.86 µM -0.0442953716952886 0.495782740144033 no 1695 0.482334480453762 570 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2124 5246320 200 µM -0.044399907865179 0.495741634313927 no 1696 0.482292817545426 587 579342 SGTC_1917 st066507 28.5 µM -0.0450148021247206 0.495499845832254 no 1697 0.482047755262417 568 3156428 SGTC_2393 9031399 185.94 µM -0.046283878659111 0.495000825377277 no 1698 0.481541994252461 586 1526623 YDL150W RPC53 SGTC_3174 9107204 49.47 µM -0.0463497722739116 0.49497491519914 no 1699 0.481515734685271 582 3938802 SGTC_3278 9139605 49.47 µM -0.0463528075274069 0.49497372170072 no 1700 0.481514525094386 604 7958859 SGTC_3298 9116858 71.43 µM -0.0471244893437007 0.494670288557337 no 1701 0.481207004671352 586 2506942 SGTC_2005 4024620 188 µM -0.0475026369534058 0.49452159818375 no 1702 0.48105631436258 566 236743 SGTC_3303 9125618 40.5795 µM -0.0478012402439081 0.494404185748241 no 1703 0.480937324058167 577 22695467 SGTC_1563 conessine 56.1 µM -0.0482808306972153 0.494215609196226 no 1704 0.480746215811476 562 441082 An anti-amoebic, histamine inhibitor. SGTC_720 r052-1644 49.9 µM -0.0483954604228273 0.494170536598909 no 1705 0.480700538562737 573 1422863 YOR257W CDC31 SGTC_1283 0922-0125 16.4 µM -0.0486036182998238 0.494088688768765 no 1706 0.48061759319441 572 3360884 SGTC_1381 2324-0066 62.1 µM -0.0492257750892137 0.493844057759197 no 1707 0.480369685305651 573 10885928 SGTC_1669 st015249 58.4 µM -0.0509860731210663 0.493151924360824 no 1708 0.479668309076772 575 722793 SGTC_2357 9067248 200 µM -0.0510155710559441 0.493140326207202 no 1709 0.47965655639816 594 9150235 SGTC_273 hydroxyurea 18.1 mM -0.0517818249788663 0.492839048508598 no 1710 0.479351268843018 570 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2345 9052315 157.45 µM -0.0518269342274257 0.492821312463252 no 1711 0.479333296988196 579 6469265 SGTC_139 0099-0334 718.624 µM -0.05277679633246 0.492447849220431 no 1712 0.478954874786425 570 97690 SGTC_2366 9070441 60.58 µM -0.052800227693677 0.492438636647463 no 1713 0.47894554004104 578 6837235 SGTC_3210 9128157 49.47 µM -0.0544939146324764 0.491772736069735 no 1714 0.478270828403654 610 17590849 SGTC_1885 st057546 99.9 µM -0.0549895231442533 0.491577883772824 no 1715 0.478073405242143 580 702008 SGTC_630 4356-0227 183 µM -0.0573974504946212 0.490631218074625 no 1716 0.477114296933313 577 779312 SGTC_3355 9151058 44.0485 µM -0.0584090006536714 0.490233547158545 no 1717 0.47671142276462 566 17015728 SGTC_3172 9105863 49.47 µM -0.059361831801517 0.489858969331081 no 1718 0.476331956616597 575 2348785 SGTC_1632 st005650 90 µM -0.0593666626199133 0.489857070257969 no 1719 0.476330032791767 583 2759605 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0593696380492715 0.489855900568514 no 1720 0.476328847857232 569 2333 A French combination drug. SGTC_1010 4112-3296 15.2 µM -0.059447882005961 0.489825141633653 no 1721 0.476297688070964 575 704384 SGTC_2831 7999036 19.48 µM -0.059465533684746 0.489818202488358 no 1722 0.476290658506072 580 2988270 SGTC_2870 9038528 12.99 µM -0.0597308694950287 0.489713895289801 no 1723 0.476184992659564 605 6463316 SGTC_1012 4112-3522 18 µM -0.0602212159248057 0.489521135142791 no 1724 0.475989724257148 595 3112398 SGTC_2805 7950783 58.44 µM -0.0606692748304685 0.489345000788595 no 1725 0.475811300861292 582 1178958 YDL195W SEC31 SGTC_1524 corynanthine 62.1 µM -0.0609529371804354 0.489233492672421 no 1726 0.475698345004963 615 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_905 2-aminofluorene 215 µM -0.0621831532320772 0.488749902657652 no 1727 0.475208489148883 572 1539 An established DNA mutagen. YPR165W RHO1 SGTC_932 2857-0803 154 µM -0.0630439458916217 0.488411540394032 no 1728 0.474865755068841 607 674898 SGTC_70 0141-0289 43.283 µM -0.0638312320913112 0.488102079507306 no 1729 0.474552304673616 572 352408 SGTC_3033 9090887 49.47 µM -0.0639351295605312 0.48806124075654 no 1730 0.474510940072237 571 19325384 SGTC_833 3852-0053 558 µM -0.0639902106049653 0.488039590221738 no 1731 0.474489010819413 583 3123681 SGTC_2202 7226349 200 µM -0.064088500205707 0.488000955921721 no 1732 0.47444987926431 575 844334 SGTC_847 0342-0274 5.54 µM -0.0641538840036437 0.487975255836268 no 1733 0.474423848471065 595 18097 SGTC_2630 antimycin a 100 µM -0.0644002151982127 0.487878432103598 no 1734 0.474325779340436 595 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1756 st041558 35.5 µM -0.0647979050072541 0.487722116376718 no 1735 0.474167454754345 599 3955792 SGTC_1738 st035555 74 µM -0.0670435964419032 0.486839462291906 no 1736 0.473273498155935 594 5331140 SGTC_3091 9116372 49.47 µM -0.0674832540869018 0.486666665188415 no 1737 0.473098496468023 579 17169793 SGTC_424 splitomicin 100 mM -0.0683059031098767 0.486343349075086 no 1738 0.472771062552189 611 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2677 mitomycin C 100 µM -0.069207612959141 0.485988970930681 no 1739 0.472412181687338 575 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_47 0149-0135 24.25 µM -0.0692840299261918 0.48595893904408 no 1740 0.472381768730542 574 5239155 SGTC_213 1246-0773 967 nM -0.0704840380747109 0.485487346103951 no 1741 0.471904202360951 595 6251622 SGTC_65 0798-0905 34.986 µM -0.0710084649043946 0.48528125717908 no 1742 0.471695509239909 610 3602145 SGTC_2131 toluylene red 5.2905 µM -0.0735918046769331 0.484266116376558 no 1743 0.470667596188901 579 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2680 butyl paraben 22.24 µM -0.0746305104953979 0.483857978286979 no 1744 0.470254348971946 589 7184 An antifungal and steroid mimetic. SGTC_324 1315-0088 19.6 µM -0.0748491607616982 0.483772066301999 no 1745 0.470167363428367 606 6787421 SGTC_1252 0493-0875 34.8 µM -0.0750460295661897 0.483694713325705 no 1746 0.47008904441239 593 3960963 SGTC_3333 9141820 12.094 µM -0.0752149343906243 0.483628348343991 no 1747 0.470021851043985 596 1939433 SGTC_2711 st079103 59.1 µM -0.0753112862006997 0.483590490622404 no 1748 0.469983520948149 592 54693780 SGTC_2462 5162487 171.77 µM -0.0762707165358517 0.483213527662334 no 1749 0.469601861391544 576 2259986 SGTC_543 3844-1095 191 µM -0.0773909730352669 0.482773394648394 no 1750 0.469156260860278 584 4230703 SGTC_855 0428-0020 25 µM -0.0777862924216834 0.482618084208015 no 1751 0.468999025235704 586 6812414 SGTC_1839 st053978 48 µM -0.0785184588037891 0.482330442553796 no 1752 0.468707823774617 584 3788398 SGTC_206 4546-0025 72.014 µM -0.0796608524225816 0.48188165590235 no 1753 0.468253497851992 599 6620745 YIL048W NEO1 SGTC_1994 st072947 40.9 µM -0.0801915764768971 0.481673169979626 no 1754 0.468042444792279 619 5286565 YDL195W SEC31 SGTC_3108 9121785 49.47 µM -0.080591724839557 0.481515981808666 no 1755 0.467883323709963 568 17140271 SGTC_34 0469-0683 81.75 µM -0.0828254188501726 0.480638585047829 no 1756 0.466995178622971 578 3690923 SGTC_910 3454-3003 490 µM -0.0832463718742858 0.480473244743841 no 1757 0.466827820623848 585 820824 SGTC_330 1488-0319 80.1 µM -0.083630239872584 0.480322473480864 no 1758 0.466675211604087 579 6846614 SGTC_2464 5717415 7.67 µM -0.0848743481489792 0.479833846379614 no 1759 0.466180642697838 587 5285744 SGTC_2875 9039966 71.43 µM -0.0853275589673231 0.479655854019437 no 1760 0.466000491268371 612 6463691 SGTC_3214 9129694 49.47 µM -0.0873915007200245 0.4788453209135 no 1761 0.465180162487614 587 17158655 SGTC_635 k038-0028 24.7 µM -0.0890485593456921 0.478194638531547 no 1762 0.46452165929872 593 4035102 SGTC_1305 1181-0477 144 µM -0.0904527868121824 0.477643281573953 no 1763 0.463963705378752 582 6252086 SGTC_2309 7664088 163.95 µM -0.0912756365404801 0.477320217036192 no 1764 0.463636788194328 606 704922 SGTC_927 2425-1185 123 µM -0.0916643251064974 0.477167616587509 no 1765 0.463482371230126 606 730375 SGTC_1656 st012921 11 µM -0.0931654774402692 0.476578290726255 no 1766 0.462886050040075 579 6732821 SGTC_2850 9015429 58.44 µM -0.0943485664108294 0.476113866946678 no 1767 0.462416135763346 589 6457570 SGTC_1705 st027868 56.3335 µM -0.095251461968723 0.475759455409513 no 1768 0.462057547512289 599 292948 SGTC_2783 7738165 71.43 µM -0.0959559813442858 0.475482925329095 no 1769 0.461777766487176 594 17201110 SGTC_1161 k007-0610 110 µM -0.0969496331883615 0.475092928303615 no 1770 0.461383196417134 599 5843850 SGTC_3135 9127742 49.47 µM -0.0985035317971104 0.474483088786056 no 1771 0.460766233815922 596 3643468 SGTC_2107 5363541 170.161 µM -0.100876962405302 0.473551733478826 no 1772 0.459824065570393 590 244052 SGTC_2855 9016525 58.44 µM -0.101736149734443 0.473214616088118 no 1773 0.459483053830826 594 43811474 SGTC_862 0452-0056 10.2 µM -0.102410319839374 0.472950106907123 no 1774 0.459215496347097 584 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_895 0964-0006 13.7 µM -0.10382110843869 0.472396625786738 no 1775 0.458655657439792 593 6738897 SGTC_1750 st081859 2.357 µM -0.105354990912836 0.471794912939725 no 1776 0.458047064641124 612 5291695 SGTC_2383 9036125 200 µM -0.105722284229205 0.47165084027601 no 1777 0.457901349589241 590 79580 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.105915871185855 0.471574906303425 no 1778 0.457824550757637 603 5377381 SGTC_1212 0520-0165 585 µM -0.107502137257446 0.470952736796087 no 1779 0.45719531493188 659 5403258 SGTC_2397 5161689 200 µM -0.107838759530605 0.470820714977749 no 1780 0.457061798247058 621 2259942 SGTC_2770 toltrazuril 17.5 µM -0.108000067394356 0.470757451857961 no 1781 0.456997819375171 595 68591 Kills coccidiodes. SGTC_233 rapamycin 362 pM -0.10857646741896 0.470531400328479 no 1782 0.456769213332247 593 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1315 1237-0019 3.69 µM -0.108651185972173 0.470502098033769 no 1783 0.45673958024896 586 825140 SGTC_2009 4012297 12.05 µM -0.109717018142269 0.470084129242191 no 1784 0.456316901687008 624 45595307 SGTC_818 4072-2707 53.5 µM -0.109984414716268 0.46997927415035 no 1785 0.456210867588521 589 882871 SGTC_3207 9114163 49.47 µM -0.110266646650357 0.469868603878575 no 1786 0.456098954022492 646 849233 SGTC_2419 paclitaxel 166.5 µM -0.111984175521589 0.469195167908875 no 1787 0.455417976873238 592 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1853 st056710 91.2 µM -0.112364974315745 0.469045870142844 no 1788 0.455267012928836 627 269167 SGTC_1070 indatraline 8.81 µM -0.11544009732079 0.467840384256557 no 1789 0.454048149161955 608 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2092 5303694 80.6725 µM -0.117138510793947 0.467174711059827 no 1790 0.453375146294515 621 1963699 SGTC_2321 7390090 138.78 µM -0.117251239870437 0.467130531451498 no 1791 0.453330481681468 605 649046 SGTC_2621 lithochol-11-enic acid 100 µM -0.118777994882713 0.466532221594293 no 1792 0.452725621394255 623 6708711 SGTC_730 1436-0052 41.2 µM -0.119125516111811 0.466396044330654 no 1793 0.452587957873024 599 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2865 9030313 51.95 µM -0.120035585444124 0.466039449541289 no 1794 0.452227479319268 590 42562754 SGTC_3037 9091026 49.47 µM -0.121260598664802 0.465559492583944 no 1795 0.451742313688473 623 25236398 YIL048W NEO1 SGTC_2207 7258803 200 µM -0.121594117296366 0.465428829507797 no 1796 0.451610236317956 606 3666799 SGTC_430 0958-0115 16.4 µM -0.123605966529483 0.464640723975833 no 1797 0.450813634056111 618 6833180 SGTC_3233 9132340 49.47 µM -0.125161760960648 0.464031364598183 no 1798 0.450197744733019 647 17682950 SGTC_2447 5741742 33.78 µM -0.125187642356096 0.464021228318631 no 1799 0.450187500125188 600 1776504 SGTC_3011 9081274 71.4286 µM -0.125489275115358 0.463903097541547 no 1800 0.450068107570028 595 6625322 SGTC_2342 7990637 118.86 µM -0.125865080649015 0.463755922359025 no 1801 0.44991936220323 637 2033102 YER133W GLC7 SGTC_2796 7949634 45.45 µM -0.126671158955252 0.463440257966719 no 1802 0.449600336870352 597 2971588 SGTC_3025 9087895 49.47 µM -0.127944620429276 0.462941610914377 no 1803 0.44909639960196 609 17173641 SGTC_1359 1582-0056 520 nM -0.12895808180113 0.46254481321017 no 1804 0.448695408835219 623 3661189 SGTC_458 nppb 133 µM -0.129114528758488 0.462483563280106 no 1805 0.448633512974707 608 4549 A chloride channel blocker. SGTC_2704 st078022 71.1 µM -0.129660734476093 0.462269727421776 no 1806 0.448417424797559 640 54697681 SGTC_612 0302-0167 22.4 µM -0.130209040252223 0.462055080372231 no 1807 0.448200521193488 610 235821 SGTC_500 h-89 112 µM -0.1307208861152 0.46185471637535 no 1808 0.447998054694938 636 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2336 9001819 198.65 µM -0.132294692157319 0.461238704915725 no 1809 0.447375602760652 604 2989602 SGTC_219 mitoxanthrone 164.414 µM -0.134125551993226 0.460522195830181 no 1810 0.446651647314181 613 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1263 0774-1208 64.8 µM -0.13443281332437 0.460401961253533 no 1811 0.446530167921543 617 906585 SGTC_48 0382-0018 55 µM -0.135033606220613 0.460166875171995 no 1812 0.446292651869278 600 762596 SGTC_1410 3909-8106 77.9 µM -0.13541843858978 0.4600163002531 no 1813 0.446140523263026 606 1039210 SGTC_1896 st058441 89 µM -0.136517408354686 0.45958633354634 no 1814 0.445706131754054 601 688759 SGTC_1423 4048-0112 5.59 µM -0.13724412292843 0.459302035845756 no 1815 0.445418917902598 611 X1423 SGTC_3202 9113761 49.47 µM -0.138410793759799 0.458845666628032 no 1816 0.444957883468035 625 4798415 SGTC_1055 3448-0672 86 µM -0.138542794055184 0.458794035183684 no 1817 0.444905725460635 631 748378 SGTC_2516 gossypol 71.55 µM -0.139439352429493 0.458443368014701 no 1818 0.444551488673685 625 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_224 benfluorex 43.875 µM -0.140110798124762 0.458180769400442 no 1819 0.444286224541595 602 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_93 0109-0045 59.227 µM -0.140293836447201 0.458109187308771 no 1820 0.444213916983353 601 88733 SGTC_723 4182-0001 115 µM -0.140497071859102 0.458029708190319 no 1821 0.444133632931432 618 744821 YLR208W SEC13 SGTC_1652 st011932 78 µM -0.14115679691233 0.457771721595564 no 1822 0.443873037665498 612 1551076 SGTC_1306 1185-0270 9.02 µM -0.143192782630196 0.456975658594345 no 1823 0.443068964855328 626 1548076 SGTC_1085 doxorubicin 7.67 µM -0.143224410959009 0.456963293386333 no 1824 0.443056475704721 605 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_786 4544-0069 423 µM -0.146185081419557 0.455805994835908 no 1825 0.441887641171312 606 748821 YLR208W SEC13 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.146259043256288 0.455777088600382 no 1826 0.441858448425096 622 4213774 SGTC_732 3970-1727 52.7 µM -0.147023908097939 0.455478173012577 no 1827 0.441556574723766 617 1275699 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.147448241970886 0.455312350638584 no 1828 0.441389115009562 652 688798 SGTC_618 k072-0232 33.2 µM -0.148250144482007 0.454999002221053 no 1829 0.441072679711276 623 5872756 YGL099W LSG1 SGTC_1409 3909-8004 61.9 µM -0.148272819679116 0.454990142152199 no 1830 0.44106373249528 604 2119279 SGTC_2915 7971052 15.16 µM -0.148748569214052 0.454804253738926 no 1831 0.44087601741684 607 5741558 SGTC_1334 1486-0610 236 µM -0.149011109657239 0.454701676210244 no 1832 0.440772433300577 606 3742339 SGTC_1765 st044815 90.4 µM -0.149946132009093 0.454336376955875 no 1833 0.440403557524609 611 645695 SGTC_2387 9077560 195.08 µM -0.151192243628229 0.453849599859417 no 1834 0.43991203432471 601 5303272 SGTC_2484 5809818 12.04 µM -0.151668828734126 0.45366344644884 no 1835 0.43972407188251 621 2870548 SGTC_3183 9108214 49.47 µM -0.151971442162069 0.453545251390068 no 1836 0.439604729925342 632 4974831 SGTC_1158 4092-0494 91.8 µM -0.152523696737991 0.453329561852973 no 1837 0.439386950896096 643 1148199 SGTC_2417 cerulenin 830 nM -0.153073855033511 0.453114704731309 no 1838 0.439170016764078 636 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1311 1190-0148 100 µM -0.153391358195919 0.452990714268759 no 1839 0.439044829700728 616 1961333 SGTC_2523 spermine 47.74 µM -0.153458151990977 0.452964630722544 no 1840 0.439018494615829 596 1103 A DNA binding polyamine. SGTC_1016 4226-1401 38 µM -0.153459730869234 0.452964014159584 no 1841 0.439017872107783 604 2901613 SGTC_141 0443-0274 32.331 µM -0.155590242289916 0.452132138524645 no 1842 0.438178008396724 627 1627241 SGTC_2037 5169046 200 µM -0.155732563996417 0.4520765752947 no 1843 0.438121913981139 627 5718022 SGTC_992 3909-8734 162 µM -0.156394440533208 0.451818187158127 no 1844 0.437861059533771 650 4288319 SGTC_1998 st075797 76.8 µM -0.158192704421219 0.45111627129321 no 1845 0.437152476199299 630 24208315 SGTC_1005 4092-0690 4.4 µM -0.159384941899794 0.450650989668579 no 1846 0.436682800939802 644 1529343 SGTC_616 4092-0450 108 µM -0.16015676680111 0.450349814030734 no 1847 0.436378792400083 622 787165 SGTC_2926 9010726 65.15 µM -0.160566396099368 0.450189983206218 no 1848 0.436217461724913 656 2994293 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.161060211648031 0.449997314990229 no 1849 0.436022988778238 666 65057 A dermal irritant. YDR527W RBA50 SGTC_35 0133-0054 64.071 µM -0.161185998977263 0.449948239396638 no 1850 0.435973454062278 629 99677 SGTC_50 0929-0078 56.389 µM -0.162100925784284 0.449591306202308 no 1851 0.435613188584441 622 1377751 SGTC_1916 st067606 49.2 µM -0.162682225188259 0.449364549608949 no 1852 0.435384321391789 618 19590279 SGTC_460 trequinsin 123 µM -0.16282567328388 0.449308595096922 no 1853 0.435327846829673 610 5537 A vasodilator. SGTC_2846 9008642 19.48 µM -0.162938630422896 0.449264534840766 no 1854 0.435283377282816 678 2992898 SGTC_1989 st071868 50.2 µM -0.16341276774533 0.449079598850593 no 1855 0.435096725399985 614 16414057 SGTC_1302 1159-0335 255 µM -0.164413776567221 0.448689194424292 no 1856 0.434702709510107 634 649284 SGTC_2428 5615643 7.78 µM -0.165735097906733 0.448173940730226 no 1857 0.434182711938905 622 2253075 SGTC_3150 9097574 49.47 µM -0.166314326387834 0.447948096148721 no 1858 0.433954796115837 659 17217476 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.167193866641192 0.44760519053055 no 1859 0.433608755102845 614 688669 SGTC_1828 st055811 49 µM -0.167465701499613 0.447499218412145 no 1860 0.433501816316637 661 5877589 SGTC_2745 rifampicin 24.3 µM -0.168377361325934 0.447143844290478 no 1861 0.433143208436439 603 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_75 0159-0059 199.013 µM -0.171909005208366 0.445767577302323 no 1862 0.431754533426368 605 5377270 SGTC_2444 5485484 36.41 µM -0.172560055989807 0.445513936327645 no 1863 0.431498625753301 652 6790631 SGTC_1807 st050092 58.9 µM -0.172686044116151 0.445464855553059 no 1864 0.431449107083083 654 5008496 SGTC_1106 tegaserod maleate 11.7 µM -0.172712820846133 0.445454424339253 no 1865 0.431438582832791 626 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_446 go6976 132 µM -0.172754861511905 0.445438046942407 no 1866 0.431422059386505 641 3501 A protein kinase C inhibitor. SGTC_467 ro 31-8220 72.8 µM -0.173192541698876 0.44526754941934 no 1867 0.431250042958266 629 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2843 9000894 45.46 µM -0.173832845521317 0.445018138472989 no 1868 0.430998415184055 601 2242070 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.174537621635558 0.444743639463983 no 1869 0.430721483351829 639 4174840 SGTC_733 4069-0007 56.1 µM -0.17636217991287 0.444033126645881 no 1870 0.430004707483394 609 5717425 YNL287W SEC21 SGTC_2760 etidronate 98.04 µM -0.177674232420676 0.443522302980865 no 1871 0.429489411394908 621 3305 A chelator and antioxidant. SGTC_2168 5727979 200 µM -0.177827398538576 0.44346267665238 no 1872 0.429429264677954 617 695210 SGTC_907 3448-6986 75.5 µM -0.178147491264024 0.443338071282747 no 1873 0.429303572935841 651 590582 SGTC_819 1013-0258 27.7 µM -0.180062535043572 0.442592702447317 no 1874 0.428551737263869 655 5753198 SGTC_1873 rapamycin 2 nM -0.180188406638969 0.442543718087605 no 1875 0.428502329816133 625 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3162 9099653 49.47 µM -0.180489428756064 0.442426575478263 no 1876 0.428384176373468 619 25237511 SGTC_1968 st069590 43.6 µM -0.180531315389088 0.442410275714263 no 1877 0.428367736063817 624 6384066 SGTC_2795 7780010 54.55 µM -0.180909116781161 0.442263262492437 no 1878 0.428219456386437 627 953673 SGTC_1232 0279-0259 161 µM -0.181352987318799 0.442090550054701 no 1879 0.4280452588072 626 1560000 SGTC_893 0958-0369 48.9 µM -0.183004057855593 0.441448206420137 no 1880 0.42739741734027 660 6819948 SGTC_2185 6113692 200 µM -0.183062815767194 0.441425349672629 no 1881 0.427374365706262 629 874150 SGTC_2771 fluoxetine 41.05 µM -0.183286425922265 0.441338367411588 no 1882 0.427286642265214 631 3386 A selective serotonin reuptake inhibitor. SGTC_703 3875-0075 71.8 µM -0.184195986796275 0.440984585934318 no 1883 0.426929853845207 632 2850814 SGTC_302 1094-0063 18.9 µM -0.184499816009666 0.440866419443138 no 1884 0.426810685741296 645 5440289 SGTC_3075 9116269 49.47 µM -0.184645319343292 0.44080983155967 no 1885 0.426753618688149 648 17015205 YNL244C SUI1 SGTC_3274 9138298 49.47 µM -0.184936852495386 0.440696454674765 no 1886 0.426639282706735 631 17015756 SGTC_1509 1326-1131 80 µM -0.187264790571731 0.439791297566162 no 1887 0.425726513831438 598 768313 SGTC_1338 1486-1223 76 µM -0.187393343317363 0.439741322357125 no 1888 0.425676120710903 643 3444526 SGTC_617 3770-0098 35 µM -0.188199203962322 0.439428063874897 no 1889 0.425360248242546 638 5962639 SGTC_530 4358-1714 28 µM -0.189135689913696 0.439064075679056 no 1890 0.424993234883025 617 1564641 SGTC_2589 lobaric acid 100 µM -0.19019441056963 0.438652640033351 no 1891 0.424578395450432 636 73157 A novel microtubule depolymerizer. SGTC_784 4579-0127 173 µM -0.191925997632399 0.437979860885476 no 1892 0.423900086414088 674 1948547 SGTC_398 bronopol 33.3 µM -0.1935101914302 0.437364505863184 no 1893 0.423279712647263 646 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1467 k284-1082 293 µM -0.193567001264378 0.437342441786328 no 1894 0.423257469314331 654 3334705 SGTC_3112 9123419 49.47 µM -0.193619155341321 0.437322186106434 no 1895 0.423237049112793 629 17015854 SGTC_3252 9135871 49.47 µM -0.193890477911903 0.437216812084505 no 1896 0.423130819871808 658 17682838 SGTC_3066 9117245 49.47 µM -0.194843095200544 0.436846877756035 no 1897 0.422757891844907 647 17176980 SGTC_2084 5306078 60.6385 µM -0.197966814107135 0.435634218462166 no 1898 0.421535514174749 660 679340 SGTC_2818 7996756 12.99 µM -0.198343603510096 0.435487985664663 no 1899 0.421388119310591 614 2241621 SGTC_2836 9010338 19.48 µM -0.198398097970913 0.435466836974024 no 1900 0.421366802733663 627 2994051 SGTC_860 0443-0016 25.1 µM -0.198846989380881 0.435292634267007 no 1901 0.421191218830182 637 5337942 SGTC_715 0868-0130 184 µM -0.198865511421576 0.435285446629712 no 1902 0.421183974269225 634 2876258 SGTC_2712 st079126 47.7 µM -0.199506835087008 0.435036588665179 no 1903 0.420933148600156 649 3152970 SGTC_474 dl-dihydrosphingosine 5 µM -0.199916325695669 0.434877704194267 no 1904 0.420773011060027 645 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1469 k284-2957 126 µM -0.200201576476182 0.434767031630578 no 1905 0.420661467142048 635 23884841 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.200759228563888 0.434550686656092 no 1906 0.420443422346106 669 165506 SGTC_3115 9123671 49.47 µM -0.201180084580898 0.434387425633487 no 1907 0.420278881666657 618 3286988 SGTC_2717 st081029 62.2815 µM -0.202078467155175 0.434038957078614 no 1908 0.419927690658256 676 5292846 SGTC_2785 7756463 72.73 µM -0.202253009441996 0.433971260792245 no 1909 0.419859466889724 633 2201551 SGTC_272 doxorubicin 8.13 µM -0.202396656243872 0.433915548783039 no 1910 0.419803321121159 624 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1244 0416-0015 52.5 µM -0.203383357872774 0.433532901727977 no 1911 0.419417703236462 643 96201 SGTC_2966 9084041 48.03 µM -0.205670383417908 0.432646223680614 no 1912 0.418524197279798 643 17741380 SGTC_1174 0739-0097 51.1 µM -0.206442323533908 0.43234701940073 no 1913 0.418222706688406 647 728447 SGTC_2534 helenine 20.12 µM -0.206903026293745 0.432168469311216 no 1914 0.418042796508917 607 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1484 3473-2379 286 µM -0.207416019001844 0.431969670017208 no 1915 0.41784248663177 641 671917 SGTC_118 0083-0097 135.343 µM -0.207956651705028 0.431760178081048 no 1916 0.417631407145557 642 5207356 SGTC_1240 0356-0016 42.1 µM -0.208442142280962 0.431572069740871 no 1917 0.417441877047741 636 4305613 SGTC_1393 3470-5649 58.2 µM -0.209399140831379 0.431201316242072 no 1918 0.417068331707606 648 4108395 SGTC_3176 9106582 49.47 µM -0.209416930028704 0.431194425051943 no 1919 0.417061388756016 621 17018027 SGTC_351 caspofungin 25 nM -0.209465790511176 0.431175497556164 no 1920 0.417042319115563 626 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1368 1852-0141 284 µM -0.209860476787545 0.431022610414504 no 1921 0.416888285115439 655 2838987 SGTC_983 1491-0821 12.2 µM -0.211059112125727 0.430558366029147 no 1922 0.416420572649767 630 46495113 SGTC_2411 st077133 39.94 µM -0.212282822676898 0.430084508733573 no 1923 0.415943197783558 691 1403142 YNL221C POP1 SGTC_2642 cholecalciferol 100 µM -0.212456039229296 0.430017442226672 no 1924 0.41587563524692 660 9821465 A vitamin D precursor, similar to steriods. SGTC_2626 ethyl orsellinate 100 µM -0.21266983466061 0.429934667051381 no 1925 0.415792248482791 634 75653 A natural product. SGTC_3038 9091290 49.47 µM -0.212703568369831 0.429921606652669 no 1926 0.415779091649556 652 25236843 SGTC_1939 st074455 53.6 µM -0.213275121932636 0.429700334696532 no 1927 0.415556188487725 662 1644229 SGTC_557 1315-0110 16.2 µM -0.2139061764559 0.429456053116362 no 1928 0.415310111797861 637 6833801 SGTC_1862 st057513 3.81 µM -0.214213998092075 0.429336904973569 no 1929 0.415190090271331 635 5393163 SGTC_3034 9090421 49.47 µM -0.214607489355485 0.429184606168612 no 1930 0.415036677162197 644 17173761 SGTC_2736 butenafine 14.65 µM -0.215217305080981 0.428948600908425 no 1931 0.414798949770308 647 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2545 solidagenone 89.61 µM -0.216536475400636 0.428438154784084 no 1932 0.414284798123808 630 6708572 An anti ulcer agent SGTC_2370 9071495 200 µM -0.217571779398213 0.428037633051708 no 1933 0.413881387259435 673 21791103 SGTC_2955 9076254 12.21 µM -0.217720103620847 0.427980257827135 no 1934 0.413823599489576 631 16459619 SGTC_2262 9014885 67.46 µM -0.218960877469188 0.427500357692115 no 1935 0.413340261753421 647 6457424 SGTC_256 clotrimazole 625 nM -0.219185114649393 0.427413639809679 no 1936 0.413252925180591 636 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_805 3852-0218 479 µM -0.220470452918592 0.426916636536546 no 1937 0.412752390703728 633 6615355 SGTC_868 0527-0199 213 µM -0.220846606449218 0.426771210710258 no 1938 0.412605936356921 631 2849450 SGTC_2457 5731572 11.68 µM -0.22116431037264 0.426648390011972 no 1939 0.412482248680819 673 2865357 SGTC_1693 xanthone 101.9 µM -0.221971514973718 0.426336365975564 no 1940 0.412168028975379 661 7020 An insecticide. SGTC_2323 6148992 148.28 µM -0.222194752554455 0.426250081868114 no 1941 0.412081139440793 646 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2167 5876490 200 µM -0.223336745177301 0.425808742791385 no 1942 0.411636715443303 646 686534 SGTC_828 2074-0507 139 µM -0.223471292200424 0.425756751314255 no 1943 0.411584361851802 641 X828 SGTC_1208 2323-2347 50.3 µM -0.223554453380326 0.425724616929935 no 1944 0.411552003792586 671 5412760 SGTC_1490 4089-0339 670 nM -0.224196910326462 0.425476381220709 no 1945 0.411302043745205 663 742542 SGTC_20 0481-0013 4.944 µM -0.225238519530528 0.425073981884043 no 1946 0.410896862491884 640 182045 SGTC_1897 st060201 15 µM -0.227103856947671 0.424353551324082 no 1947 0.410171492496982 639 611878 SGTC_335 4077-0256 27.6 µM -0.23023309014481 0.423145547607338 no 1948 0.408955325102109 676 3121989 SGTC_1849 st056239 19.2 µM -0.230245430854901 0.423140785043395 no 1949 0.408950530647459 650 5393181 SGTC_2801 7907800 81.82 µM -0.230321779906888 0.423111320437409 no 1950 0.408920868794383 667 6620925 SGTC_3329 9141233 27.5565 µM -0.230322796069078 0.423110928283265 no 1951 0.40892047401561 672 4909101 YNL103W MET4 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.230447435512168 0.423062828395793 no 1952 0.408872052321953 630 688664 SGTC_949 1165-0505 146 µM -0.231449584473652 0.422676128578138 no 1953 0.408482773927433 643 6244267 SGTC_2270 7924575 90.91 µM -0.231793481248392 0.422543446075753 no 1954 0.408349210198555 672 1262135 SGTC_295 k015-0027 31 µM -0.234397301952025 0.421539124293802 no 1955 0.407338276521435 655 3887424 SGTC_928 2764-0428 58.7 µM -0.234491847974345 0.421502666431113 no 1956 0.407301580583656 663 662578 SGTC_2038 4100038 30.985 µM -0.235816586091182 0.420991905479329 no 1957 0.406787498619522 652 3596803 SGTC_1752 st044819 83.042 µM -0.235833055003318 0.420985556623594 no 1958 0.406781108651369 645 441209 YML126C ERG13 SGTC_2954 9074818 52.69 µM -0.236386518018196 0.420772205562263 no 1959 0.406566378427281 688 16648742 SGTC_808 0711-0032 135 µM -0.236432885113621 0.420754332850648 no 1960 0.406548390393433 651 4252555 SGTC_2986 9022445 71.43 µM -0.236528495330348 0.420717479347033 no 1961 0.406511299199102 688 6459286 SGTC_2998 9066762 71.4286 µM -0.23667396235635 0.420661409584704 no 1962 0.406454868076204 672 4945196 SGTC_1384 3089-0840 101 µM -0.236925040447638 0.420564636189552 no 1963 0.406357471751704 651 1069836 SGTC_2186 6124449 200 µM -0.236929226059763 0.420563022963629 no 1964 0.406355848149614 651 3834182 YLR033W RSC58 SGTC_2286 7945697 125 µM -0.237591481528267 0.420307792129447 no 1965 0.406098979054553 664 1245733 SGTC_2421 5690543 90.72 µM -0.238533073678267 0.419944963669146 no 1966 0.405733833217638 685 3397993 SGTC_1122 capsaicin 818.572 nM -0.239318028065215 0.419642545212375 no 1967 0.405429493568858 686 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1971 st069429 63.5 µM -0.24220213359354 0.418531798059629 no 1968 0.404311770947117 662 1246522 YGL099W LSG1 SGTC_1786 berberine 21.6 µM -0.242227882552361 0.418521884349289 no 1969 0.404301795551689 675 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1793 st048256 72.231 µM -0.243210587602323 0.418143567854436 no 1970 0.403921132677182 645 672022 SGTC_535 2293-4129 48.2 µM -0.243758068446612 0.417932834450711 no 1971 0.403709098681347 695 396118 YIL048W NEO1 SGTC_737 1950-0117 57.9 µM -0.244899162683644 0.417493686345984 no 1972 0.403267255017567 652 5393513 SGTC_469 w7 172 µM -0.245755448225795 0.417164213905256 no 1973 0.402935773321546 646 45115570 A P450 inhibitor. SGTC_2941 9056145 11.23 µM -0.247088998596579 0.416651220480742 no 1974 0.402419673831338 677 2119517 SGTC_1562 morin hydrate 59.1 µM -0.247407753011555 0.416528622232843 no 1975 0.402296337314303 681 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1391 3442-0225 151 µM -0.247454301669341 0.416510719524229 no 1976 0.402278326928518 641 5227075 SGTC_3219 9131112 49.47 µM -0.248712437694613 0.416026903562418 no 1977 0.401791613608079 649 17612988 YMR079W SEC14 SGTC_1636 st007707 68.9 µM -0.249329029419951 0.415789839745797 no 1978 0.401553138989263 696 403051 SGTC_3352 9151559 45.5865 µM -0.249421252422062 0.415754384982162 no 1979 0.401517473730679 640 17159339 SGTC_2730 imipramine 71.33 µM -0.24994164413996 0.415554335331579 no 1980 0.401316238832165 662 3696 A tricyclic antidepressant. SGTC_2046 4110841 106 µM -0.251380238907461 0.415001422916619 no 1981 0.400760072175028 689 44119630 YMR134W ERG29 SGTC_2226 7298446 200 µM -0.252745754944149 0.414476753413364 no 1982 0.400232344068213 674 3283010 SGTC_511 blebbistatin 171 µM -0.253708913130614 0.414106772758651 no 1983 0.399860223819295 668 3476986 A myosin inhibitor. SGTC_527 4476-4215 268 µM -0.254308021489343 0.41387667401202 no 1984 0.39962880161113 639 4418754 SGTC_3022 9087993 49.47 µM -0.254513480313744 0.413797770520017 no 1985 0.399549445560535 636 17173644 SGTC_485 niflumic acid 177 µM -0.254684290913421 0.413732175827093 no 1986 0.399483475137364 666 4488 A COX2 inhibitor. SGTC_1602 st001878 87.6 µM -0.255364318737976 0.413471055401259 no 1987 0.399220863450175 711 595405 YLR310C CDC25 SGTC_3342 9147791 14.508 µM -0.256163284503064 0.413164313496384 no 1988 0.398912378833103 654 1838168 SGTC_116 0155-0182 31.788 µM -0.256665977284282 0.412971344968499 no 1989 0.398718319018145 663 771486 SGTC_2886 9058944 51.95 µM -0.256773681486392 0.412930003322111 no 1990 0.398676744080255 645 4949929 SGTC_2612 dictamnine 15.46 µM -0.257912186420349 0.41249305380848 no 1991 0.398237339781666 672 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1235 benzylparaben 21.5 µM -0.25829013932294 0.412348022311572 no 1992 0.398091497912383 682 7180 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.259376754781717 0.411931123159226 no 1993 0.397672281575008 697 6708760 SGTC_2957 9076800 11.52 µM -0.260140972932545 0.411637976907982 no 1994 0.397377516879246 692 16459615 SGTC_913 3487-1245 167 µM -0.260563230697176 0.411476024298044 no 1995 0.397214674001512 644 4016153 SGTC_3340 9146634 11.102 µM -0.260623024679294 0.411453092151435 no 1996 0.397191616017211 683 4907387 SGTC_148 3253-0744 288.01 µM -0.262122344068431 0.410878173306659 no 1997 0.396613560402652 649 6893655 SGTC_969 1313-0238 134 µM -0.262728233930582 0.410645897120243 no 1998 0.396380026756797 656 5212874 SGTC_297 0986-0032 24 µM -0.26285258553861 0.410598229098967 no 1999 0.396332101379186 669 2847425 SGTC_3153 9100258 49.47 µM -0.263473698652584 0.410360155997468 no 2000 0.396092746513206 698 25236848 SGTC_2158 5657123 3.6195 µM -0.264622830123256 0.409919780227041 no 2001 0.395650015511596 726 2858827 SGTC_1741 st038134 10.228 µM -0.264908920762539 0.409810160815652 no 2002 0.395539813003009 684 1272587 SGTC_2372 9071633 200 µM -0.266553659721599 0.409180094339955 no 2003 0.394906419570235 646 21321366 SGTC_2139 5578692 56.4705 µM -0.268837497374326 0.408305591282246 no 2004 0.394027368240432 673 650991 YMR113W FOL3 SGTC_608 k048-0125 159 µM -0.269966567420645 0.407873428013227 no 2005 0.39359298712495 687 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2021 4019055 173 µM -0.271271573909113 0.407374062893422 no 2006 0.393091083884966 684 44827708 YER133W GLC7 SGTC_2857 9024691 58.44 µM -0.272231708003525 0.407006760398847 no 2007 0.392721931358155 720 16478292 SGTC_1864 st057645 30.4 µM -0.273387229594421 0.406564820217636 no 2008 0.392277784163477 671 688666 SGTC_2354 9060492 162 µM -0.273440993667349 0.406544260531005 no 2009 0.392257122307724 687 6471895 SGTC_1953 st076800 12.1 µM -0.27411285082866 0.406287360281811 no 2010 0.391998949203079 654 297591 SGTC_2735 sertaconazole 140 nM -0.275422852517944 0.405786566692475 no 2011 0.391495694494782 652 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1308 1187-1617 41.4 µM -0.276596718174641 0.405337946745976 no 2012 0.391044892469554 666 2882570 SGTC_2363 9053361 176 µM -0.279345604217739 0.404287883761183 no 2013 0.38998980576557 699 6469797 YMR079W SEC14 SGTC_718 1130-0073 349 µM -0.279418898827018 0.404259894925952 no 2014 0.38996168463396 696 6740020 SGTC_584 0986-0246 15.4 µM -0.280055347597066 0.404016876389948 no 2015 0.38971752092224 690 53315 YDR232W HEM1 SGTC_3261 9137475 49.47 µM -0.280208569597099 0.403958376367173 no 2016 0.389658746171169 645 17027690 SGTC_2078 5212016 200 µM -0.280397462662314 0.403886260119992 no 2017 0.389586291753855 691 1899708 SGTC_2824 7998404 51.95 µM -0.280406915208666 0.403882651379993 no 2018 0.389582666106209 655 837851 SGTC_3316 9136639 10.545 µM -0.28218177328322 0.403205201352969 no 2019 0.388902066738811 697 4903665 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.284830987905926 0.402194556776012 no 2020 0.387886815110707 675 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1796 st049173 110.4 µM -0.286713920710903 0.401476636684945 no 2021 0.387165688860515 699 94134 SGTC_1667 st014849 34.6 µM -0.287124978936208 0.401319953518428 no 2022 0.387008313316863 656 5348460 SGTC_591 4299-0174 154 µM -0.287517793968991 0.401170238939555 no 2023 0.386857939618559 686 5509088 SGTC_940 3232-1287 54.8 µM -0.28812210293206 0.400939945487938 no 2024 0.386626637000772 715 1585493 YIL048W NEO1 SGTC_1154 4088-0362 150 µM -0.289332885699323 0.400478637234477 no 2025 0.386163324408145 683 6618304 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.289464217180422 0.400428608270194 no 2026 0.386113079449191 667 5106787 A p450 inhibitor. SGTC_52 0329-0193 875 nM -0.289743703429162 0.40032214717484 no 2027 0.386006159616252 709 3739292 SGTC_807 1315-0151 48 µM -0.289973292100458 0.400234698460912 no 2028 0.385918335001412 704 4011080 SGTC_2216 7189485 200 µM -0.291229566267029 0.399756281118669 no 2029 0.385437875750144 674 731273 SGTC_1261 0712-0010 12.7 µM -0.291393379407421 0.399693908478397 no 2030 0.385375238718122 693 2840123 SGTC_1711 st032263 62.8 µM -0.291480008096399 0.399660925223412 no 2031 0.385342115819797 671 3958979 SGTC_1921 5740136 50 µM -0.291590870017853 0.399618716382634 no 2032 0.385299728447856 708 1774243 SGTC_1253 0550-0034 176 µM -0.2918595238719 0.399516435743309 no 2033 0.385197015988061 663 5969915 SGTC_231 b-estradiol 524 µM -0.293097201966684 0.39904532189139 no 2034 0.384723927707327 662 450 A steroid. SGTC_3122 9126309 49.47 µM -0.294488673218888 0.398515843286865 no 2035 0.384192258678661 684 17591206 SGTC_1141 3253-0389 52.6 µM -0.294572775307498 0.398483846979421 no 2036 0.384160130975194 703 5402031 SGTC_768 0384-0033 77.3 µM -0.296156293058009 0.397881531520057 no 2037 0.3835553627154 684 3965305 YMR134W ERG29 SGTC_1941 st076221 61.8 µM -0.296374883239003 0.397798406444492 no 2038 0.383471902214847 651 2828568 SGTC_1166 k206-0078 225 µM -0.296458932248831 0.397766445675005 no 2039 0.383439812676977 671 5404595 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.296991308867319 0.397564018232155 no 2040 0.3832365722341 680 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2640 pentamidine 10.38 µM -0.297164237984624 0.397498270714862 no 2041 0.383170561613458 704 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_606 k015-0008 38.6 µM -0.297955048964693 0.397197642121726 no 2042 0.382868735958776 689 1970475 SGTC_1663 st014140 55.4 µM -0.29938508369128 0.396654166338828 no 2043 0.382323121016942 680 4207120 SGTC_2919 7978188 46.38 µM -0.301340676417035 0.395911280593077 no 2044 0.381577363127187 643 2980291 SGTC_2114 5491910 81.25 µM -0.301572726859898 0.395823154872509 no 2045 0.381488900677253 699 2849228 SGTC_551 k048-0028 34.9 µM -0.302747168192354 0.395377219436372 no 2046 0.381041274280177 713 6836383 SGTC_1344 1488-0097 29.1 µM -0.303706465806389 0.395013075676058 no 2047 0.380675765776305 678 747966 SGTC_354 2783-3500 4.88 µM -0.305509649708056 0.394328845977659 no 2048 0.379989010831628 677 6740761 SGTC_1265 0819-1001 68.8 µM -0.306060868534928 0.394119747409193 no 2049 0.379779150752613 685 3106768 SGTC_2136 5328288 199.296 µM -0.31099872623263 0.392247995232894 no 2050 0.377900794985243 680 262395 SGTC_1987 st072290 61.9 µM -0.312232181766661 0.391780826656951 no 2051 0.377432038130478 693 54697379 SGTC_2814 7977482 42.97 µM -0.313215654313244 0.391408450331827 no 2052 0.377058412977734 689 6456762 SGTC_2069 5228469 200 µM -0.314167107797163 0.391048292202598 no 2053 0.376697061506234 710 2835210 SGTC_930 2810-3379 265 µM -0.314543618896226 0.390905795479145 no 2054 0.37655409657835 732 1015764 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.314866093227478 0.390783761489036 no 2055 0.376431663396152 694 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1818 st052136 56.3 µM -0.314933238273312 0.390758353135808 no 2056 0.376406172134592 683 674169 SGTC_2694 st077685 81.9 µM -0.315460972023604 0.390558669681866 no 2057 0.376205839582829 657 2838096 SGTC_2056 5235370 200 µM -0.315891898623458 0.390395637439126 no 2058 0.376042280640721 698 5511916 SGTC_1837 st055472 66.5 µM -0.31615213854609 0.390297190331889 no 2059 0.375943516904902 691 676091 SGTC_3238 9133470 49.47 µM -0.316517174494471 0.390159111409346 no 2060 0.375804995689764 683 3534688 SGTC_2473 5854593 8.94 µM -0.316525990004635 0.390155777015501 no 2061 0.375801650641242 677 2872951 SGTC_2945 9067681 61.76 µM -0.316677077569265 0.390098630649535 no 2062 0.37574432186119 719 16456930 SGTC_269 exalamide 29 µM -0.318843188892696 0.389279596637196 no 2063 0.374922713067243 666 3316 A derivative of salicylamide. SGTC_1246 0422-0085 105 µM -0.31887621987769 0.389267111001796 no 2064 0.374910188754541 709 264295 SGTC_1666 st014829 29 µM -0.319779371387166 0.388925766174738 no 2065 0.374567793207288 689 3858230 SGTC_1478 0453-0656 35.7 µM -0.320506772908162 0.388650908115987 no 2066 0.374292098456783 704 5258496 SGTC_1269 0831-0796 3.05 µM -0.320509441865948 0.388649899718366 no 2067 0.37429108700491 704 927758 SGTC_1030 k029-0042 36.7 µM -0.320533475094662 0.388640819409715 no 2068 0.37428197919874 694 6080581 SGTC_2896 9052656 71.43 µM -0.322252126622052 0.387991631228699 no 2069 0.373630848780859 711 6469436 SGTC_488 nitrendipine 139 µM -0.322449110558548 0.387917244217189 no 2070 0.373556242202172 673 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2895 9054447 58.44 µM -0.322589931038581 0.387864068723348 no 2071 0.373502910127129 677 2697450 SGTC_1959 st077091 55.8 µM -0.322824490717021 0.387775500858271 no 2072 0.373414082160445 690 821356 YKL052C ASK1 SGTC_623 k072-0108 16.9 µM -0.323824921247426 0.387397811872503 no 2073 0.373035293769681 699 5382803 SGTC_979 1426-2828 121 µM -0.323933364220622 0.387356878176473 no 2074 0.372994241872181 701 747872 SGTC_1856 st057054 55.7 µM -0.32584295837643 0.386636274058229 no 2075 0.372271587409142 722 1266018 SGTC_3138 9097216 49.47 µM -0.325929629342889 0.386603577167819 no 2076 0.372238798855428 698 25237486 SGTC_3259 9138485 49.47 µM -0.326822318818932 0.386266854183436 no 2077 0.371901138816239 680 17646153 SGTC_1767 st044992 70.3 µM -0.327164724828265 0.386137721149846 no 2078 0.371771649772205 700 9600693 SGTC_261 5-fluorouridine 15.376 µM -0.327904631171226 0.385858720218631 no 2079 0.371491885999433 675 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1448 4255-0083 152 µM -0.328567138751314 0.38560895459138 no 2080 0.371241444827133 731 5399660 SGTC_679 0422-0091 41.4 µM -0.32929549274501 0.385334419571952 no 2081 0.370966175297087 701 627384 YHR062C RPP1 SGTC_2909 7941780 10.49 µM -0.3301095408659 0.385027652262934 no 2082 0.370658597194171 707 1243215 SGTC_1339 1486-1321 22.7 µM -0.33136153057378 0.384555990759101 no 2083 0.370185709587409 691 3469382 SGTC_1719 st032227 49.2 µM -0.331430981183549 0.384529831657957 no 2084 0.370159483212599 669 3125804 SGTC_1604 st002052 72.4 µM -0.332292613589036 0.384205335010973 no 2085 0.369834158418763 669 6254834 YHR062C RPP1 SGTC_1470 k295-0292 231 µM -0.332455711602717 0.384143920312294 no 2086 0.369772588310035 678 5045612 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.334690559860006 0.383302679884821 no 2087 0.36892926165481 712 1377 SGTC_2659 sanguinarine 24.21 µM -0.336107461006612 0.38276961527913 no 2088 0.368394916162412 708 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_976 1348-1067 47.6 µM -0.337132037815985 0.382384288635125 no 2089 0.36800868350103 675 5310671 YGL099W LSG1 SGTC_3021 9087658 49.47 µM -0.337355821734517 0.382300142629167 no 2090 0.367924341863181 693 25237042 SGTC_366 0181-0206 4.31 µM -0.337613277661846 0.382203342334057 no 2091 0.367827317501031 713 274874 SGTC_2292 7671323 168.05 µM -0.338190486328417 0.381986345664564 no 2092 0.367609822371959 695 937504 SGTC_629 3448-6466 76.7 µM -0.338281634865574 0.381952082537687 no 2093 0.367575481024193 711 573744 SGTC_1186 1319-0216 26 µM -0.338683031658436 0.381801206762928 no 2094 0.367424262380297 678 4565136 SGTC_1698 5-fluorocytosine 1.055 µM -0.339992030682979 0.381309309138956 no 2095 0.36693126471205 696 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_556 4058-0063 51.5 µM -0.340471451523904 0.381129199568719 no 2096 0.366750759178608 715 6615692 SGTC_762 1165-0429 115 µM -0.340863388005188 0.380981975385753 no 2097 0.366603214047173 722 5967793 SGTC_595 3909-8003 73.7 µM -0.341049561938511 0.380912048390965 no 2098 0.366533135468232 717 699517 SGTC_3181 9108277 49.47 µM -0.341352828333008 0.380798149755275 no 2099 0.366418991110337 720 17097298 SGTC_665 3914-0008 307 µM -0.342580973177392 0.380336997561384 no 2100 0.365956859008975 708 1069549 SGTC_662 k832-1615 104 µM -0.342812378832828 0.380250126805678 no 2101 0.365869806349793 702 5878478 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.342953502972783 0.380197151114062 no 2102 0.365816720148133 743 6728940 SGTC_2275 7947463 200 µM -0.343137028572934 0.380128261970237 no 2103 0.365747687772509 670 1225414 SGTC_2331 7980721 200 µM -0.344524257986174 0.379607667321405 no 2104 0.365226028077729 683 2981221 SGTC_2425 5628681 7.85 µM -0.344527487350258 0.379606455671005 no 2105 0.365224813984277 706 5714958 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.346142416318816 0.379000686174181 no 2106 0.364617843897761 721 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_199 4063-0024 41.6 µM -0.346253218411228 0.378959134521111 no 2107 0.364576211416561 709 306215 SGTC_1155 4088-0394 48.2 µM -0.346599956527977 0.378829114049136 no 2108 0.364445939287845 693 2326248 SGTC_2271 7849410 118.62 µM -0.347795132148489 0.378381050151956 no 2109 0.363997022849901 735 972430 SGTC_107 0358-0022 2.6945 µM -0.348042795063905 0.378288223295252 no 2110 0.363904022219513 738 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3054 9094397 49.47 µM -0.348052532390919 0.37828457377864 no 2111 0.363900365890929 725 2598354 SGTC_3229 9132204 49.47 µM -0.348700290584619 0.378041820642157 no 2112 0.363657163043492 687 17682924 SGTC_2051 5263410 176 µM -0.350185360688758 0.37748545928323 no 2113 0.363099796271803 692 227584 SGTC_658 3253-0951 102 µM -0.350819323228944 0.377248031154625 no 2114 0.362861949803569 698 1184878 SGTC_3199 9111318 49.47 µM -0.350947503170044 0.377200031550859 no 2115 0.362813866406226 702 8548020 SGTC_321 4534-3890 65.3 µM -0.351831322434376 0.376869119007428 no 2116 0.362482383326036 703 699746 SGTC_835 0312-0010 67.2 µM -0.352455052909507 0.376635641242836 no 2117 0.362248510524481 708 1626196 SGTC_2821 7996764 71.43 µM -0.352656616286914 0.376560200720445 no 2118 0.362172943687924 658 2987135 SGTC_1108 betulinic acid 729.144 nM -0.353005891510722 0.376429486225239 no 2119 0.362042011867387 673 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2761 levamisole 97.89 µM -0.354517967354368 0.375863763078724 no 2120 0.361475370639323 732 26879 An alkaline phosphatase inhibitor. SGTC_1437 4092-1038 11.6 µM -0.355642348182726 0.375443263713022 no 2121 0.361054212559436 699 3977136 SGTC_1755 st041960 45.185 µM -0.355788127916144 0.375388755387766 no 2122 0.360999620327083 738 2257073 SGTC_809 3998-0021 90 µM -0.357325179600603 0.374814189825139 no 2123 0.360424190994802 737 715485 SGTC_91 0417-1751 58.384 µM -0.357630581972654 0.374700060347896 no 2124 0.360309894442637 707 6795624 SGTC_250 brefeldin a 552.239 µM -0.359126858272808 0.374141057671998 no 2125 0.3597500950086 693 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3126 9127922 49.47 µM -0.359481801502083 0.374008491116021 no 2126 0.359617344761617 755 45595682 SGTC_2912 7964298 10.93 µM -0.359490302516213 0.37400531628341 no 2127 0.35961416555453 695 2975850 SGTC_1057 3448-5381 134 µM -0.360720970913316 0.373545794792154 no 2128 0.359154023116186 696 5497911 SGTC_1508 1080-0625 72.9 µM -0.360859423956367 0.373494108796799 no 2129 0.359102268795943 683 767111 SGTC_1051 3253-3903 78 µM -0.362617315727581 0.372838067238213 no 2130 0.3584453867004 688 5509239 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.364889130275221 0.371990777021467 no 2131 0.357597084256345 719 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1475 4092-1048 11.7 µM -0.365048110699418 0.371931507230398 no 2132 0.357537746755667 725 2881759 SGTC_2491 paeonol 100 µM -0.365126616604595 0.371902240415396 no 2133 0.357508446655867 694 11092 Increases levels of cortical cytochrome oxidase. SGTC_3102 9121669 49.47 µM -0.365981036602686 0.371583762567358 no 2134 0.357189612999206 691 41905072 SGTC_2150 5556613 200 µM -0.366446929541865 0.371410141912604 no 2135 0.357015803306299 705 743190 SGTC_1729 st035615 45.989 µM -0.366737184936408 0.37130198794304 no 2136 0.356907533339378 679 17385451 SGTC_3231 9132313 49.47 µM -0.367192826519534 0.371132228838573 no 2137 0.356737594891509 724 4905967 SGTC_298 1391-0729 10 µM -0.369632976072764 0.370223525884948 no 2138 0.355827988628226 698 3237558 SGTC_2315 7733312 200 µM -0.370069121854164 0.370061182864384 no 2139 0.355665494298167 696 726316 SGTC_2799 7812892 81.82 µM -0.370661961262064 0.369840552163262 no 2140 0.355444662860212 722 20205235 SGTC_1300 1094-0077 113 µM -0.371199207673457 0.369640647910318 no 2141 0.355244581604401 688 5532636 SGTC_749 1000-0129 128 µM -0.37142652637061 0.369556075400148 no 2142 0.355159935606658 745 708470 SGTC_2003 4023581 200 µM -0.372377753813357 0.369202245634549 no 2143 0.35480580739442 703 16641307 SGTC_859 0439-0102 54.6 µM -0.372461864408436 0.369170964193581 no 2144 0.354774500268074 713 610143 SGTC_221 trifluoperazine 10.304 µM -0.373278868160612 0.368867158702276 no 2145 0.354470451236857 721 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1064 honokiol 6.76 µM -0.377028682563385 0.367473831541397 no 2146 0.353076144774633 720 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2163 5671233 125 µM -0.377054358474086 0.367464297071419 no 2147 0.353066604382982 671 701023 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.377600139648742 0.367261646507567 no 2148 0.35286383046658 734 689007 SGTC_1257 0669-0121 16 µM -0.38066847714355 0.366123051080392 no 2149 0.351724631218898 695 4307855 SGTC_2784 7567673 72.73 µM -0.381468048631532 0.365826539986586 no 2150 0.351427987779249 723 3471247 SGTC_909 3448-9333 149 µM -0.383459836882794 0.365088258980107 no 2151 0.350689422032929 695 3344074 SGTC_3012 9080433 71.4286 µM -0.384137985818796 0.364837008585414 no 2152 0.350438089327331 729 17688859 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.38413950279026 0.364836446620969 no 2153 0.350437527187096 677 6708630 An antioxidant. SGTC_1973 st070275 50.2 µM -0.384732438097163 0.364616815060997 no 2154 0.35021782976511 716 17118334 SGTC_3006 9075424 71.4286 µM -0.385722916010409 0.364250027270092 no 2155 0.349850944629271 716 7465181 SGTC_2606 farnesol 9.78 µM -0.386832360819165 0.36383933196596 no 2156 0.349440159115868 712 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1794 st048918 76.9 µM -0.387118488830782 0.363733438180727 no 2157 0.349334245292334 715 672303 SGTC_3113 9123498 49.47 µM -0.387653170767159 0.363535584394062 no 2158 0.349136357606841 729 8897275 SGTC_3301 9125354 19.7965 µM -0.388253610156811 0.363313441092303 no 2159 0.348914181744553 682 41905162 SGTC_714 4296-0578 26.1 µM -0.388550423200506 0.363203646764512 no 2160 0.348804373473072 709 1589775 SGTC_1307 1187-1599 12.2 µM -0.390085413329407 0.362636017001889 no 2161 0.348236694317555 709 1538471 SGTC_2161 5662504 8.5105 µM -0.391551192255847 0.362094262734056 no 2162 0.34769492841794 677 2859334 SGTC_197 4544-0043 41.561 µM -0.392027296088568 0.361918353350325 no 2163 0.347519022724397 715 896523 SGTC_2699 st077704 54.6 µM -0.39403353945784 0.36117741351312 no 2164 0.346778138661903 717 645852 SGTC_2127 5253358 187.912 µM -0.395890130708087 0.360492206358016 no 2165 0.346093041038405 721 20612 SGTC_2312 7706453 155.7 µM -0.396786424888535 0.360161573582644 no 2166 0.345762481063889 719 976098 SGTC_1119 parthenolide 318.541 nM -0.396830398379942 0.360145354948647 no 2167 0.345746266335431 752 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2580 diallyl disulphide 81.36 µM -0.397678863716386 0.359832466896186 no 2168 0.345433459753108 672 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2756 carbadox 75.1 µM -0.397866046583844 0.359763452219525 no 2169 0.345364464614829 711 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_100 0086-0128 49.5915 µM -0.398357972782496 0.359582099905036 no 2170 0.345183166344981 762 93297 SGTC_921 1561-0023 372 µM -0.399670914262886 0.35909822900324 no 2171 0.344699458814958 728 24050882 SGTC_36 0335-0881 14.2 µM -0.39971139114911 0.35908331525497 no 2172 0.344684550545464 720 23828853 SGTC_2055 5235184 200 µM -0.400750441015242 0.358700549888319 no 2173 0.344301934872616 772 2836034 SGTC_164 4100-3994 89.624 µM -0.402463670251798 0.358069740170286 no 2174 0.343671410026447 746 4615967 SGTC_948 3448-0295 75.3 µM -0.402859175113681 0.357924170537243 no 2175 0.343525912886338 715 678569 SGTC_3200 9114385 49.47 µM -0.403382769554437 0.357731487995068 no 2176 0.343333330197348 722 17018030 YLR208W SEC13 SGTC_1714 st033236 13.627 µM -0.403675945400186 0.35762361522996 no 2177 0.343225515274716 734 2916566 SGTC_2781 5567276 71.43 µM -0.407207017296007 0.356325268414765 no 2178 0.341927974043042 745 2853274 SGTC_316 k060-0003 58.6 µM -0.407529827380011 0.356206656510491 no 2179 0.341809445817494 722 6152314 SGTC_861 0443-0273 110 µM -0.408724338267522 0.355767871795487 no 2180 0.341370985355699 721 6149169 SGTC_2192 5915882 198.485 µM -0.409214993070148 0.355587692814111 no 2181 0.341190946229395 723 2876149 SGTC_2553 4-methylesculetin 85.09 µM -0.410305567176869 0.35518732618767 no 2182 0.340790904357266 732 5319502 SGTC_1427 4048-4900 550 nM -0.410617176686897 0.355072958850443 no 2183 0.340676633333531 734 24132586 SGTC_2648 atorvastatin 78.68 µM -0.411189443556104 0.354862958712502 no 2184 0.340466814150328 741 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2520 obtusaquinone 4.71 µM -0.411710168919665 0.354671910653245 no 2185 0.340275935334348 716 5967872 SGTC_2888 9058547 12.99 µM -0.412867495671071 0.354247431918331 no 2186 0.339851848395018 711 16476514 SGTC_2343 7990716 14.84 µM -0.41441531765287 0.353680012230779 no 2187 0.339284986430029 726 6456862 SGTC_528 3492-0019 172 µM -0.414679039845944 0.353583366057482 no 2188 0.339188439131079 718 2869262 SGTC_2071 5230951 39.92 µM -0.415928335864111 0.353125665355615 no 2189 0.338731222035746 714 1799272 SGTC_2688 kanamycin b 96.69 µM -0.416749090378009 0.352825083634955 no 2190 0.338430971712467 734 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1997 st073024 93.8 µM -0.416815893746641 0.35280062253743 no 2191 0.338406538065616 726 686268 SGTC_3155 9099265 49.47 µM -0.417242226255901 0.352644528562636 no 2192 0.338250620970866 752 25236499 SGTC_1077 5-fluorocytosine 377 nM -0.417584307375 0.352519299654192 no 2193 0.338125536103682 754 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_327 1273-0057 3.96 µM -0.418166349868309 0.35230626252858 no 2194 0.337912748390364 733 3108138 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.419299470274836 0.351891654773172 no 2195 0.337498641833109 731 368090 SGTC_1417 3966-0327 90.4 µM -0.421827311711835 0.350967354886632 no 2196 0.336575534518146 730 651118 SGTC_82 0054-0107 293.755 µM -0.421997927759493 0.350905001172276 no 2197 0.336513264999853 735 3104697 SGTC_1139 k015-0024 46.9 µM -0.423005403683403 0.350536888716392 no 2198 0.336145659261766 759 2766652 SGTC_442 cape 100 µM -0.423694845554799 0.350285060667869 no 2199 0.335894187381609 730 5281787 SGTC_279 1273-0055 2.93 µM -0.423735269557873 0.350270297290581 no 2200 0.335879445124757 739 2847562 SGTC_264 promethazine 12.5 mM -0.424400902768966 0.35002723184113 no 2201 0.335636731229103 750 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1805 st050013 60.3 µM -0.424421838252818 0.350019587946956 no 2202 0.335629098507553 739 4037144 SGTC_1280 0880-0253 10.1 µM -0.426862405972017 0.349128913207177 no 2203 0.334739774512013 750 6836607 SGTC_2506 ethyl hematommate 54.16 µM -0.430912490065095 0.347652686645952 no 2204 0.333266000697094 738 3940691 An allergen. SGTC_894 0960-0238 55.9 µM -0.431521912099067 0.347430755842307 no 2205 0.333044461765006 746 6741907 YDL195W SEC31 SGTC_2061 5245884 80.95 µM -0.432225658308944 0.347174540438123 no 2206 0.332788706303194 744 573863 SGTC_1803 st050068 52.4 µM -0.432852490949846 0.346946386031333 no 2207 0.33256096826513 732 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_96 0929-0093 37.281 µM -0.433539915249834 0.346696241268073 no 2208 0.332311287368273 724 6991579 SGTC_1103 duloxetine 36.1 µM -0.433669111107841 0.346649236031445 no 2209 0.332264370158167 738 60835 A selective serotonin reuptake inhibitor. SGTC_1004 4084-0029 199 µM -0.433803912717846 0.346600193774724 no 2210 0.332215420032934 710 716894 YLR208W SEC13 SGTC_62 0180-0423 3.232 µM -0.434646108663923 0.346293852182506 no 2211 0.331909660649164 760 30102 YGL099W LSG1 SGTC_3297 9117502 71.43 µM -0.435292396090213 0.346058838803502 no 2212 0.331675101764284 727 7453720 SGTC_2687 chenodiol 100 µM -0.435511063750152 0.345979336785881 no 2213 0.331595755039176 705 5702181 A cholesterol synthesis inhibitor. SGTC_3060 1327-0027 12.5 µM -0.435665083556362 0.345923343163804 no 2214 0.331539871258624 746 16000455 YPR107C YTH1 SGTC_2264 7948757 110.76 µM -0.436850721075272 0.345492419665064 no 2215 0.331109806052109 728 2971411 SGTC_1781 st038725 66.3 µM -0.437007845041419 0.345435327499279 no 2216 0.331052829321255 709 4270275 YIL048W NEO1 SGTC_736 0958-0254 92.6 µM -0.437711526087996 0.345179682892488 no 2217 0.330797706546865 765 6812352 SGTC_1762 st045503 25.4615 µM -0.438857480235967 0.344763513390041 no 2218 0.330382403845299 739 4645554 SGTC_2024 5144227 134 µM -0.440729293485636 0.344084141882312 no 2219 0.329704493442631 730 3475211 SGTC_1379 2144-0755 36.5 µM -0.440740590673763 0.344080043111451 no 2220 0.329700403660587 750 5392327 SGTC_165 k038-0023 64.381 µM -0.441663263070808 0.343745347117108 no 2221 0.329366448709528 727 46368543 SGTC_800 3448-7362 155 µM -0.441819190905209 0.343688796959536 no 2222 0.329310025132115 754 15991913 SGTC_3277 9138724 49.47 µM -0.442684896030407 0.343374896383126 no 2223 0.328996834405491 736 15943418 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.446515887848881 0.341987096008454 no 2224 0.327612319330456 755 364106 SGTC_1219 1469-0211 33.1 µM -0.448476319259776 0.341277741106969 no 2225 0.326904736432448 764 6822282 SGTC_1521 st012942 49.4 µM -0.45008991084061 0.340694305735982 no 2226 0.326322805661456 734 24207259 SGTC_2563 tomatine 8.54 µM -0.45129158271943 0.340260057857333 no 2227 0.325889705317362 797 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_462 ag-879 158 µM -0.45198496415762 0.340009587078964 no 2228 0.325639907177925 752 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2355 9061122 103.12 µM -0.452825996498681 0.339705874991423 no 2229 0.325337021268286 747 5302957 SGTC_2122 5258151 111.688 µM -0.452915826016739 0.339673442063618 no 2230 0.325304677251039 748 2173356 SGTC_2231 micatex 6.853 µM -0.452981046576427 0.339649894938632 no 2231 0.325281194760134 737 20737 An antifungal of unknown mechanism. SGTC_395 anisomycin 6.25 µM -0.453773652669434 0.339363783762373 no 2232 0.324995874490191 752 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_314 1671-0008 2.74 µM -0.45583818578308 0.338618973387147 no 2233 0.32425317129366 776 3913060 SGTC_1778 st046819 58.9 µM -0.456467317039741 0.338392130377685 no 2234 0.324026983930239 750 671715 SGTC_1978 st071761 42 µM -0.456519386038035 0.338373358720845 no 2235 0.32400826681973 717 5147680 SGTC_2194 5927483 104.545 µM -0.456909614544354 0.338232688264654 no 2236 0.323868006534657 711 760979 SGTC_2065 5221596 34.26 µM -0.457071854610871 0.338174210241563 no 2237 0.323809699757633 743 788581 SGTC_3114 9122766 49.47 µM -0.457249345961613 0.33811023949713 no 2238 0.323745916837943 719 17176985 SGTC_1754 st042065 16.137 µM -0.457699786851883 0.337947914323755 no 2239 0.323584070584799 762 1126236 YIL048W NEO1 SGTC_1221 2958-7315 257 µM -0.457805873296997 0.337909688383605 no 2240 0.323545957909135 741 4562705 SGTC_2860 9025725 38.96 µM -0.458061179150712 0.337817701331766 no 2241 0.323454244173196 766 40546248 SGTC_251 melphalan 456.522 µM -0.458358194154766 0.337710698604346 no 2242 0.323347560720726 741 460612 A DNA alkylator. SGTC_2707 st078556 66.6 µM -0.460577906894263 0.336911439951211 no 2243 0.322550732653977 753 17250899 SGTC_1442 4112-3290 3 µM -0.460805219824599 0.336829632176327 no 2244 0.322469178218055 764 704353 SGTC_111 0083-0039 52.457 µM -0.461694955721755 0.336509498906251 no 2245 0.322150044468341 751 759313 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.464503886153662 0.335499604171211 no 2246 0.32114338795822 746 279621 SGTC_1350 1495-0454 146 µM -0.465144104873932 0.335269592224099 no 2247 0.320914131645216 740 1069057 SGTC_631 k072-0230 41.5 µM -0.465271884107026 0.335223692254502 no 2248 0.320868383270737 746 5773147 SGTC_620 0109-0052 432 µM -0.465807130489149 0.33503145150447 no 2249 0.320676780350022 761 493037 SGTC_414 piperonyl butoxide 100 µM -0.46801346244588 0.334239475109838 no 2250 0.319887481228896 748 5794 A potent inhibitor of cytochrome P450. SGTC_66 0109-0187 42.4 µM -0.469787830583036 0.33360308950288 no 2251 0.31925330485008 719 759417 SGTC_135 0933-0004 26.348 µM -0.469815495288535 0.333593171207716 no 2252 0.319243421395578 759 21230617 YGL099W LSG1 SGTC_914 3820-6779 408 µM -0.470153402375397 0.333472034819172 no 2253 0.319122711544769 720 2893481 SGTC_769 0302-0231 76 µM -0.470191076575899 0.333458530062055 no 2254 0.319109254455872 762 571869 YER009W NTF2 SGTC_1658 st012944 20 µM -0.470622964691553 0.333303730147178 no 2255 0.318955002608164 765 24207260 SGTC_291 SEC14.278 35.5 µM -0.471371677086818 0.333035439461303 no 2256 0.318687669056661 740 1068044 SGTC_1578 josamycin 24.2 µM -0.472416866684733 0.332661053192349 no 2257 0.318314633809777 771 5282165 A P450 substrate. SGTC_1452 4194-0072 190 µM -0.472994559488689 0.332454195546658 no 2258 0.318108530333078 760 1343545 SGTC_593 1203-0218 61.7 µM -0.473454632971369 0.332289490989351 no 2259 0.317944430181401 769 3666956 SGTC_2685 mycophenolic acid 18.85 µM -0.473655692513296 0.332217522604844 no 2260 0.317872726986056 742 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.474079155948781 0.332065965959385 no 2261 0.317721730968205 721 6312947 SGTC_340 k038-0059 454 µM -0.474160641907678 0.332036805461909 no 2262 0.31769267867706 729 23733424 SGTC_824 1304-0008 100 µM -0.474482558172607 0.331921614723574 no 2263 0.317577916445286 734 768245 SGTC_2883 9059145 45.46 µM -0.475281191509992 0.331635909750557 no 2264 0.317293281636129 776 16476510 SGTC_3185 9108267 49.47 µM -0.476132034367894 0.331331634945279 no 2265 0.316990158076977 762 4910486 SGTC_1230 0170-0365 3.77 µM -0.477034124276891 0.331009154953352 no 2266 0.316668911199156 738 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2287 7945887 168.79 µM -0.477673201608311 0.33078077278601 no 2267 0.316441410420651 738 1245853 SGTC_1614 st002383 48.6 µM -0.47817603574966 0.330601123064653 no 2268 0.316262458733549 737 1947235 SGTC_2935 9038016 29.96 µM -0.478928234768772 0.33033245453273 no 2269 0.315994841877083 760 6463195 SGTC_2565 isoliquiritigenin 100 µM -0.479027686539491 0.330296939144088 no 2270 0.315959466205752 717 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1806 st050005 60.3 µM -0.479343145209802 0.330184295285652 no 2271 0.315847266563098 732 5194765 SGTC_3156 9099931 49.47 µM -0.479436367709748 0.330151010377447 no 2272 0.31581411322841 729 18111053 SGTC_2483 5729050 27.16 µM -0.480969324013277 0.329603864338821 no 2273 0.315269150513429 773 2865180 SGTC_3232 9132874 49.47 µM -0.481162796054181 0.329534835767598 no 2274 0.315200400137876 756 3784940 SGTC_245 methotrexate 289.6 µM -0.481265669804692 0.329498133976352 no 2275 0.315163846511041 728 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_410 α-linolenic acid 100 µM -0.482685134549377 0.328991885922682 no 2276 0.31465965993135 753 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2558 carylophyllene oxide 100 µM -0.484030339605978 0.328512411673477 no 2277 0.314182168699626 775 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1318 1280-3875 124 µM -0.485450947384718 0.328006367877869 no 2278 0.313678250108763 773 373245 SGTC_1942 st076330 65.2 µM -0.48620326067254 0.327738509288571 no 2279 0.313411529872553 784 24208414 SGTC_2319 6033012 152.6 µM -0.486370910955035 0.327678830044464 no 2280 0.31335210552351 738 847246 SGTC_2937 9044753 11.33 µM -0.487480300676039 0.327284026467097 no 2281 0.312958999837411 704 6465530 YGL099W LSG1 SGTC_38 0929-0051 58.268 µM -0.489433376135105 0.326589446102195 no 2282 0.312267455773056 762 1379719 SGTC_2361 9034121 116 µM -0.491103341509446 0.325996025602122 no 2283 0.31167667912851 770 6496917 SGTC_2879 9041815 71.43 µM -0.492131479301817 0.325630896827274 no 2284 0.311313199929704 755 4942971 SGTC_3292 9120825 59.784 µM -0.492842855866061 0.325378359239396 no 2285 0.311061813438227 782 24824900 SGTC_3311 9131146 2.8755 µM -0.492872612060848 0.325367797581774 no 2286 0.311051300103428 751 4900406 YPR165W RHO1 SGTC_2330 7979373 200 µM -0.493166988568425 0.325263319203213 no 2287 0.310947300530949 741 1863007 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.49374354408778 0.325058731305577 no 2288 0.310743654357185 738 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1079 idarubicin 2.36 µM -0.495942672166082 0.324278866115503 no 2289 0.309967429147655 774 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1194 1488-0194 225 µM -0.495999441084491 0.324258744637375 no 2290 0.309947402639834 750 1391452 SGTC_79 0052-0007 94.094 µM -0.498287601158841 0.323448144769307 no 2291 0.309140672853551 770 2801472 SGTC_2619 obliquin 87.91 µM -0.498482686769945 0.323379072737822 no 2292 0.309071934584963 759 6708593 A bioactive alkalod. YER133W GLC7 SGTC_14 0354-0009 295 µM -0.498668479542338 0.323313296588428 no 2293 0.30900647685532 771 1713507 SGTC_428 3448-4153 16.5 µM -0.499467498683293 0.323030483090004 no 2294 0.308725038927114 733 3834874 SGTC_396 dithiazanine 1.25 µM -0.499743934065 0.322932662359515 no 2295 0.308627696433537 746 10578 An antihelmenthic. SGTC_2281 7943571 200 µM -0.500532481607726 0.322653690516852 no 2296 0.308350095377266 771 1244024 SGTC_1373 2887-0003 58.5 µM -0.501562431523899 0.32228946581063 no 2297 0.307987675793502 738 776948 SGTC_2838 9002687 71.43 µM -0.503670123948255 0.321544647246732 no 2298 0.307246603074045 768 6457060 SGTC_1734 st037168 69.4 µM -0.504962809857474 0.321088190962619 no 2299 0.306792478615407 761 708907 SGTC_779 1360-0071 233 µM -0.505164955040476 0.321016836521609 no 2300 0.306721491181807 773 7566 SGTC_1702 st027038 51 µM -0.505217719793543 0.320998212384496 no 2301 0.306702962947726 756 5521182 SGTC_1281 0884-0031 11.8 µM -0.505877927354879 0.320765219978348 no 2302 0.306471174191176 754 1548255 SGTC_2339 9000433 200 µM -0.508814756304806 0.319729646468614 no 2303 0.305441037549323 738 2988954 SGTC_2416 tofa 880 nM -0.510630745319143 0.319090001064846 no 2304 0.304804821482402 765 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_347 4534-1311 26.2 µM -0.511147801023729 0.318907977015145 no 2305 0.304623783266174 763 2862016 SGTC_710 3448-4187 58 µM -0.511588273886335 0.318752947597068 no 2306 0.304469596958152 744 3946412 SGTC_2544 sphondin 68.51 µM -0.511970071601942 0.318618595218952 no 2307 0.30433597782948 752 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1416 3966-0321 25.3 µM -0.512686418374725 0.31836658133117 no 2308 0.304085345835215 772 582530 YLR208W SEC13 SGTC_846 0335-0850 148 µM -0.514309499269603 0.317795885495285 no 2309 0.303517810666808 774 6819598 SGTC_2557 derrustone 83.84 µM -0.514893241050854 0.317590740166929 no 2310 0.303313812113758 803 629853 An antioxidant. SGTC_1025 k007-0731 70 µM -0.515496726008072 0.317378715332085 no 2311 0.303102978421478 762 6256118 SGTC_667 1498-1044 59 µM -0.516283707094397 0.317102312060318 no 2312 0.302828136993561 783 6739982 SGTC_1607 st000305 50.6 µM -0.516955367282091 0.31686649243515 no 2313 0.302593657972967 790 5457690 SGTC_342 k048-0088 23.3 µM -0.517835591229821 0.316557558779852 no 2314 0.302286491836197 732 6820570 SGTC_1282 0886-0010 32.4 µM -0.519653132888748 0.315920058164663 no 2315 0.301652679038061 755 2836211 YNL267W PIK1 SGTC_1000 4048-0884 8.67 µM -0.520017878661036 0.315792189861584 no 2316 0.30152555699642 781 13040088 SGTC_1316 1272-0050 65.9 µM -0.520765910024338 0.315530022752627 no 2317 0.3012649268094 795 7340392 SGTC_1550 gossypolone 36.6 µM -0.522216208563146 0.315021992313943 no 2318 0.300759900945512 760 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_362 0310-0100 9.03 µM -0.522408819798512 0.314954548100025 no 2319 0.300692858219533 748 790235 SGTC_1709 st033179 39.1045 µM -0.522492289469548 0.314925322508519 no 2320 0.300663806794973 752 573381 SGTC_289 k017-0060 526 µM -0.523672836733231 0.314512096637706 no 2321 0.300253055818818 773 5512909 SGTC_1449 4112-4002 201 µM -0.524407665188596 0.314255002551775 no 2322 0.299997513140001 755 2059539 SGTC_560 2332-1943 155 µM -0.52600209263868 0.313697470894327 no 2323 0.299443376503301 783 21177716 SGTC_537 1334-0398 209 µM -0.526114012785937 0.31365835115738 no 2324 0.299404496557907 767 5846986 SGTC_220 paclitaxel 373.376 µM -0.526328996177245 0.313583213337794 no 2325 0.299329819889587 767 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2436 5633522 8.09 µM -0.526420333742763 0.313551292721614 no 2326 0.299298095414206 782 5724242 SGTC_10 0279-0212 42.575 µM -0.528354913988303 0.31287552464669 no 2327 0.298626512049074 771 39851 YBR002C RER2 SGTC_2828 7998861 71.43 µM -0.528850903871089 0.312702371560771 no 2328 0.298454441171534 746 2988188 SGTC_1094 duloxetine 25.4 µM -0.529093313772658 0.312617759821116 no 2329 0.298370359734264 753 60834 A selective serotonin reuptake inhibitor. SGTC_2518 prenyletin 46.28 µM -0.529195467253748 0.312582106711097 no 2330 0.298334930370103 761 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1104 tacrolimus 29.8 µM -0.529608704763018 0.312437898470433 no 2331 0.298191628886489 760 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2984 9022109 38.96 µM -0.531793877937447 0.311675812519792 no 2332 0.29743438168523 796 6459207 SGTC_1098 clofazimine 15.1 µM -0.532062573675754 0.311582159618465 no 2333 0.297341328864104 792 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2175 5807670 165.306 µM -0.53308239014723 0.311226817329045 no 2334 0.296988274280882 761 241186 SGTC_68 0986-0284 82.829 µM -0.533829732780214 0.31096652676688 no 2335 0.296729670386927 756 423278 YIL048W NEO1 SGTC_23 0213-0011 39.996 µM -0.533840414562199 0.310962807114096 no 2336 0.296725974904175 788 627608 SGTC_1499 4480-0877 67.3 µM -0.53445518419902 0.310748762127464 no 2337 0.296513323942695 763 2861909 SGTC_1785 bathophenanthroline 24 µM -0.535830261354897 0.31027023195084 no 2338 0.296037932922599 765 72812 An iron chelator. SGTC_1082 camptothecin 424.86 nM -0.536205523551406 0.310139695527083 no 2339 0.295908258243647 787 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1507 4075-3230 155 µM -0.537029466976861 0.309853167522104 no 2340 0.295623629935352 787 659771 SGTC_2611 pyromycin 23.93 µM -0.537114553327014 0.309823585145484 no 2341 0.295594244330618 766 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_787 4152-0075 138 µM -0.537927371775341 0.309541050778943 no 2342 0.295313595316523 754 9566539 SGTC_872 0588-0139 234 µM -0.539730363325093 0.308914735662502 no 2343 0.294691498563055 737 2047100 SGTC_3007 9078383 71.4286 µM -0.539802649385481 0.308889636819292 no 2344 0.29466656988589 754 6496995 SGTC_2327 6189656 200 µM -0.539996954628376 0.308822175443754 no 2345 0.294599566315519 795 5349088 SGTC_683 panaxydol 45 µM -0.540393582665793 0.308684489078551 no 2346 0.294462816251964 760 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1895 st058434 18.3 µM -0.541536816119251 0.308287774911157 no 2347 0.294068814386494 805 5393175 SGTC_1880 MG-132 525 µM -0.541567938606172 0.308276978204446 no 2348 0.294058091798026 771 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3268 9137683 49.47 µM -0.544622701743203 0.307218058112291 no 2349 0.293006518958272 820 1953228 SGTC_3000 9075062 71.4286 µM -0.546497834840672 0.306568846078188 no 2350 0.292361887815253 777 17057871 SGTC_2964 9083345 53.42 µM -0.547260450713962 0.30630498518062 no 2351 0.292099905366162 768 17741579 SGTC_3002 9075603 71.4286 µM -0.547268745240122 0.306302115872011 no 2352 0.292097056537269 773 20105405 SGTC_2244 6635614 200 µM -0.548019840848666 0.306042340150168 no 2353 0.291839139682031 784 836499 SGTC_2288 7946289 167.31 µM -0.551974489160255 0.304676186832576 no 2354 0.290482915846553 792 1246052 SGTC_249 wiskostatin 11.211 µM -0.552597955044561 0.304461055071874 no 2355 0.29026937129844 779 2775510 A n-wasp and actin depolymerizer. SGTC_1160 4092-0570 10.5 µM -0.553876445589019 0.304020113550614 no 2356 0.289831703085544 787 4994975 SGTC_2866 9034245 58.44 µM -0.556217287270066 0.303213514062579 no 2357 0.289031161377728 767 6462273 SGTC_2047 4141938 200 µM -0.561288078240941 0.30146952809432 no 2358 0.287300583709339 788 3807862 SGTC_1500 4488-1866 171 µM -0.56205958440578 0.301204581808791 no 2359 0.287037711671427 797 2900003 SGTC_1364 1653-0028 37.6 µM -0.56218370665746 0.301161966243733 no 2360 0.286995430660342 780 5718652 SGTC_822 1487-0950 154 µM -0.564009921951447 0.300535276133375 no 2361 0.286373689839182 760 1958375 SGTC_1628 st004252 77.7 µM -0.566883363802564 0.299550410485873 no 2362 0.285396713805444 758 692968 SGTC_3005 9076496 71.4286 µM -0.567905345298602 0.299200481627902 no 2363 0.285049621093567 791 21368410 SGTC_2296 7971656 126.45 µM -0.567942383191371 0.299187803250557 no 2364 0.28503704579792 776 666570 SGTC_253 dyclonine 31.25 µM -0.56991693014293 0.298512252756643 no 2365 0.284367020721475 789 3180 An oral anasthetic. SGTC_839 0122-0028 230 µM -0.570613586624995 0.298274071832001 no 2366 0.284130803300123 807 759448 SGTC_1296 1068-0102 11.9 µM -0.570911986245436 0.298172078016731 no 2367 0.284029652752107 782 767053 SGTC_144 4161-2749 112.381 µM -0.574386126601334 0.296985778245322 no 2368 0.282853269458027 785 797501 YMR168C CEP3 SGTC_1076 itraconazole 331 nM -0.575786038074859 0.296508367526623 no 2369 0.282379905911063 772 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2368 9071271 200 µM -0.575930562785989 0.296459100410134 no 2370 0.282331058294844 796 27209959 SGTC_1901 st060216 58.6 µM -0.576107935520413 0.296398640839298 no 2371 0.282271113998255 788 688792 SGTC_2269 7935389 174.42 µM -0.578186308483624 0.295690624645441 no 2372 0.28156917073168 775 97605 SGTC_634 1611-4317 11.2 µM -0.581429842854126 0.294587241661631 no 2373 0.280475394585101 790 2843522 SGTC_379 3970-0972 5.9 µM -0.582586770935882 0.29419413891012 no 2374 0.280085756562369 794 2898042 YBL034C STU1 SGTC_2201 6605497 169.863 µM -0.582805277841053 0.29411992152536 no 2375 0.280012195800727 788 670741 SGTC_3279 9140807 49.47 µM -0.583034374096394 0.29404211668748 no 2376 0.279935080173497 802 45595718 SGTC_3304 9125678 46.087 µM -0.583237657938011 0.293973086135543 no 2377 0.279866661834953 799 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_778 3456-2434 196 µM -0.585663356233093 0.293149953163912 no 2378 0.279050881740615 773 5539063 SGTC_1150 3909-7983 10.9 µM -0.586136936749774 0.292989373816167 no 2379 0.278891748170404 795 23965914 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.586601045294627 0.292832045785145 no 2380 0.278735840243347 821 5357218 A potent inhibitor of glutathione S-transferases. SGTC_456 gingerol 170 µM -0.587270434381198 0.292605198860421 no 2381 0.278511047202928 823 442793 A herb. SGTC_2967 9089538 49.85 µM -0.588095586363665 0.292325678400021 no 2382 0.278234067735557 815 728216 SGTC_882 0843-0131 351 µM -0.588107518301481 0.292321637363791 no 2383 0.278230063517163 785 5425421 SGTC_916 4466-0038 42 nM -0.589492391771132 0.291852793423905 no 2384 0.277765507207244 799 5722064 YGL116W CDC20 SGTC_924 2046-0044 21.3 µM -0.590054481399855 0.291662599988314 no 2385 0.277577062162634 789 3623589 SGTC_659 k018-0002 107 µM -0.59017848521709 0.291620648780386 no 2386 0.277535497303259 795 6797879 YHR007C ERG11 SGTC_2601 securinine 100 µM -0.590764034695341 0.291422592022765 no 2387 0.277339267980668 816 442872 A GABA receptor antagonist. SGTC_572 0960-0087 17.7 µM -0.5912528562161 0.291257300687796 no 2388 0.277175506103592 810 6796365 SGTC_2614 arthonioic acid 13.39 µM -0.592589894125304 0.290805415035959 no 2389 0.276727821984753 797 6710684 SGTC_1465 k213-0056 144 µM -0.59326175393131 0.290578466891438 no 2390 0.276502995115743 799 24048857 YMR208W ERG12 SGTC_887 0885-0007 9.62 µM -0.593347129374123 0.29054963377711 no 2391 0.276474432038138 793 5719458 SGTC_2597 laccaic acid a 100 µM -0.595807770679293 0.289719198475777 no 2392 0.27565182598051 792 5491415 A textile dye. SGTC_698 k064-0052 127 µM -0.597898611569416 0.289014442661645 no 2393 0.274953793184414 827 5088751 SGTC_1331 1472-0049 76.2 µM -0.597942002218608 0.288999825602665 no 2394 0.274939316330655 802 24051409 SGTC_63 0099-0242 26.702 µM -0.598592545311199 0.28878071809255 no 2395 0.274722314208906 801 3898502 YLR359W ADE13 SGTC_3350 9150499 3.57 µM -0.598791372495545 0.288713767299547 no 2396 0.274656008137884 802 4910996 YPR165W RHO1 SGTC_1172 0370-0043 85 µM -0.599159257590603 0.288589909155941 no 2397 0.274533344446168 793 376585 SGTC_480 am 92016 50 µM -0.599191906182053 0.288578918362767 no 2398 0.274522459753154 839 2129 K+ channel blocker. SGTC_3182 9108849 49.47 µM -0.599517307870287 0.288469386202895 no 2399 0.274413985930887 785 17133045 SGTC_1810 st050138 53 µM -0.599581460278902 0.288447794429812 no 2400 0.27439260299166 826 3444541 SGTC_1703 st026983 48.3 µM -0.599854659370117 0.288355852355102 no 2401 0.274301550935342 787 1104023 SGTC_1927 st060202 13.8 µM -0.600094359794001 0.288275195260918 no 2402 0.274221675635305 803 688887 SGTC_546 peri-Naphthalide 147 µM -0.600094487971051 0.28827515213331 no 2403 0.274221632925979 783 223824 A penicillin ester. SGTC_2881 9058953 51.95 µM -0.601118478114478 0.287930708308717 no 2404 0.273880538432755 762 17122249 SGTC_158 k038-0087 26.446 µM -0.601505817648883 0.287800467971915 no 2405 0.273751569057962 780 X158 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.603128017893992 0.287255316500308 no 2406 0.273211764445697 804 2374 Ca(2+)-ATPase inhibitor. SGTC_3250 9135583 49.47 µM -0.606761601604341 0.286036002313735 no 2407 0.272004567116745 788 7699353 SGTC_55 0767-0285 6.563 µM -0.607190191588369 0.285892343573428 no 2408 0.271862350366192 815 3116166 SGTC_3178 9107506 49.47 µM -0.607416718927914 0.285816427911551 no 2409 0.271787197942724 790 8897194 SGTC_3111 9122088 49.47 µM -0.608393491045588 0.28548919402891 no 2410 0.271463263709527 788 16876704 SGTC_2450 5739737 12.93 µM -0.608563949933747 0.28543210592934 no 2411 0.271406752872143 805 2262825 SGTC_2146 5545642 200 µM -0.610381599937691 0.284823698099905 no 2412 0.27080452699406 787 825326 SGTC_878 0828-0289 13.7 µM -0.611156844813328 0.284564394792332 no 2413 0.270547875046439 806 745350 YLR208W SEC13 SGTC_598 3937-0236 20.2 µM -0.611676471871936 0.28439065346537 no 2414 0.270375915775142 821 1379313 SGTC_2254 7938975 95.19 µM -0.612313377412919 0.284177768334596 no 2415 0.27016522028433 824 2969277 SGTC_2893 9048488 25.97 µM -0.613110805891014 0.283911336027778 no 2416 0.26990153783265 798 6467338 SGTC_171 k064-0041 9.68 µM -0.61318341093643 0.283887083578673 no 2417 0.26987753621587 792 53325 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.614428376803899 0.283471378798601 no 2418 0.269466144441942 800 641818 YHR062C RPP1 SGTC_653 0203-0016 55.2 µM -0.61476183663128 0.283360083262551 no 2419 0.26935600796549 801 295302 SGTC_1073 triclabendazole 3.09 µM -0.615588416416612 0.283084294403012 no 2420 0.269083099164372 794 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2143 5623677 140.463 µM -0.615597789645377 0.283081167758216 no 2421 0.269080005235835 788 5375313 SGTC_851 0394-0702 453 µM -0.615834053577881 0.2830023622472 no 2422 0.269002024801335 818 762646 SGTC_817 1391-0715 46 µM -0.616635881482213 0.282734992195828 no 2423 0.268737460934599 821 1353946 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.618762222363358 0.282026550668613 no 2424 0.268036506295451 795 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_150 3970-0969 77.2 µM -0.61905497937452 0.281929078634138 no 2425 0.267940070207492 821 6615640 SGTC_301 4119-0100 24.5 µM -0.619293096781939 0.281849810562234 no 2426 0.26786164565239 813 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1672 st016598 6.51 µM -0.622076522737265 0.280924019627872 no 2427 0.266945775813039 809 4665860 YNL267W PIK1 SGTC_2006 4011487 200 µM -0.622088719198213 0.280919966218618 no 2428 0.266941766123179 804 45595294 SGTC_961 1252-1571 372 µM -0.623708569531284 0.280381871543276 no 2429 0.266409497082924 820 6813498 SGTC_2991 9074669 71.4286 µM -0.625401574715041 0.279820009637363 no 2430 0.265853764440918 823 17333109 SGTC_790 1575-0012 79.1 µM -0.626399605474469 0.279489046732033 no 2431 0.265526434137227 822 378741 YLR208W SEC13 SGTC_2884 9058502 51.95 µM -0.627965939681628 0.278970008936996 no 2432 0.265013126392282 804 6471554 SGTC_1291 0993-0025 5.79 µM -0.628499364186516 0.278793354592643 no 2433 0.264838431517623 790 4353356 SGTC_965 1291-5240 308 µM -0.628684839002063 0.278731943604526 no 2434 0.264777702808212 825 2834598 SGTC_1764 st044502 93.5 µM -0.628869408651392 0.278670838855988 no 2435 0.264717277500104 802 8407 SGTC_610 4215-0184 155 µM -0.631792864772594 0.277703852520388 no 2436 0.263761118344714 797 5605015 SGTC_1646 st011709 75.6 µM -0.632521039883611 0.277463250536692 no 2437 0.263523232288477 812 5757843 SGTC_188 3229-0966 278.469 µM -0.632585386271887 0.277441994248469 no 2438 0.26350221636336 810 5722370 SGTC_2008 4012253 172 µM -0.633142149787227 0.277258105352724 no 2439 0.263320409712243 810 603940 SGTC_3237 9133362 49.47 µM -0.635942177533377 0.276334211776963 no 2440 0.262407055291934 824 43845137 SGTC_1784 st039334 36.3 µM -0.637794327546411 0.275723909773097 no 2441 0.261803786286686 836 3496984 SGTC_3313 9133968 57.047 µM -0.638019782207752 0.275649665456866 no 2442 0.261730401412503 810 1494643 SGTC_1930 st074634 34.3 µM -0.638583259100604 0.275464150267658 no 2443 0.261547037390281 821 684253 YOR116C RPO31 SGTC_1993 st073995 70.8 µM -0.638907699575574 0.275357361626117 no 2444 0.261441489408443 820 3098394 SGTC_1710 st031758 61.5 µM -0.640301784686123 0.274898734522488 no 2445 0.260988210353914 811 5394341 SGTC_3264 9137442 49.47 µM -0.640487192535244 0.274837767291459 no 2446 0.26092795647782 807 17015726 SGTC_3139 9095020 49.47 µM -0.640605480066235 0.274798874560926 no 2447 0.26088951911311 785 25236292 SGTC_1597 7-benzyloxygramine 47.5 µM -0.641021379686071 0.274662149047153 no 2448 0.260754396248973 818 260807 SGTC_1213 1315-0166 115 µM -0.641165435290065 0.27461479910621 no 2449 0.260707601993382 793 768401 SGTC_2030 5175110 200 µM -0.641668464633991 0.274449488911954 no 2450 0.260544234517768 836 2831986 SGTC_2434 5670830 169.91 µM -0.642254841870956 0.274256850166597 no 2451 0.260353864924992 834 1549830 SGTC_2097 5376186 200 µM -0.642921770418241 0.274037829607236 no 2452 0.260137431173046 800 742755 SGTC_310 1273-0058 1.06 µM -0.64374941507476 0.273766149821535 no 2453 0.259868970345104 788 2734232 SGTC_644 1498-1197 63.3 µM -0.644122586426743 0.273643697464742 no 2454 0.259747972543156 808 6741615 SGTC_440 fluspirilene 35.1 µM -0.644514487654613 0.273515128271199 no 2455 0.259620933036668 823 3396 An atypical antipsychotic. SGTC_1943 st076331 65.2 µM -0.646049142168667 0.273011949349544 no 2456 0.259123765203487 818 24208415 SGTC_1610 st001799 48.1 µM -0.646114730768583 0.272990454543153 no 2457 0.259102528044464 821 621897 SGTC_3339 9145883 14.936 µM -0.646281029250932 0.272935958685389 no 2458 0.259048685719016 808 2030670 SGTC_1090 efavirenz 20.7 µM -0.64999620794922 0.271719906367079 no 2459 0.257847335534963 810 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_202 3594-0513 34.79 µM -0.651033845750852 0.271380749193206 no 2460 0.257512319430071 816 708429 SGTC_299 1273-0059 1.44 µM -0.65210671386538 0.271030298756104 no 2461 0.257166166612554 811 2848077 SGTC_380 3970-0968 6 µM -0.653111528745632 0.270702282633995 no 2462 0.256842190199214 810 2891601 SGTC_3326 9140064 16.379 µM -0.654432396390778 0.2702713946483 no 2463 0.256416634159635 836 1868434 SGTC_1772 st048439 82.2 µM -0.654788695145329 0.270155223096309 no 2464 0.256301905075665 803 2927068 YDL195W SEC31 SGTC_1424 4048-1941 275 µM -0.65965358882142 0.268571522780734 no 2465 0.25473807818479 817 X1424 SGTC_2634 4'-methoxyflavone 100 µM -0.661019398465393 0.268127742332196 no 2466 0.254299936667036 804 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_896 0964-0007 44.5 µM -0.661446166262881 0.267989152161339 no 2467 0.254163113802203 811 6756758 SGTC_3096 9117468 49.47 µM -0.661865009353167 0.267853170568847 no 2468 0.254028869167471 817 41316311 SGTC_2740 felodipine 17.08 µM -0.665503816445814 0.266673260033997 no 2469 0.252864151672206 790 3333 L-type calcium channel blocker SGTC_389 tpck 16.7 µM -0.666096262626094 0.266481403932185 no 2470 0.252674786619817 809 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2495 cafestol 54.53 µM -0.666132454390339 0.266469685956463 no 2471 0.252663220976928 834 16667697 An anti-infammatory. SGTC_1872 amphotericin b 148 nM -0.666319099278613 0.266409259211937 no 2472 0.252603580118014 816 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_721 1187-1332 279 µM -0.667555647722802 0.266009098784286 no 2473 0.252208638494262 834 25730 SGTC_1190 1486-1332 13 µM -0.669928542132105 0.265242058194011 no 2474 0.251451671916861 829 4150046 SGTC_2172 5754775 163.918 µM -0.670114490892822 0.265181997545484 no 2475 0.251392403995444 816 2263357 SGTC_3198 9112019 49.47 µM -0.671804184466627 0.264636550493727 no 2476 0.250854182240483 861 45595555 SGTC_1126 isoteolin 1.0172 µM -0.672106113697455 0.264539145372412 no 2477 0.250758072347203 818 133323 SGTC_2786 7743617 45.45 µM -0.672947421108881 0.264267828197439 no 2478 0.250490370875468 818 583674 SGTC_1980 st071811 45.7 µM -0.674044986762567 0.263914082233624 no 2479 0.250141356596505 837 4974850 SGTC_1904 st060225 78 µM -0.67493799024152 0.263626444954403 no 2480 0.249857581349427 803 66595 SGTC_3089 9117425 49.47 µM -0.675177443551837 0.263549344015127 no 2481 0.249781517854101 849 9401657 SGTC_2437 5741531 144.16 µM -0.676286182891291 0.263192494015808 no 2482 0.249429481793262 835 2262990 SGTC_641 4092-0595 30 µM -0.67659612633521 0.263092782254237 no 2483 0.249331118766549 829 786260 SGTC_1455 4262-0120 131 µM -0.679367765407777 0.262201978475697 no 2484 0.248452434460864 829 1529587 SGTC_823 0417-1665 178 µM -0.682256128054259 0.261275306882934 no 2485 0.247538504545812 846 3429856 SGTC_712 r015-0009 80.6 µM -0.683030670303603 0.261027097377161 no 2486 0.247293731201506 831 6813872 YLR060W FRS1 SGTC_427 1354-0053 47.3 µM -0.683416740007756 0.260903422920119 no 2487 0.247171772547987 838 6813657 SGTC_3116 9124943 49.47 µM -0.683809789557099 0.260777543490222 no 2488 0.247047642027184 808 41905195 YPL160W CDC60 SGTC_942 3253-1115 227 µM -0.685889246966493 0.260112089517056 no 2489 0.246391475756922 860 46497897 SGTC_1115 galangin 695.678 nM -0.686656310039267 0.259866840353678 no 2490 0.24614966744286 851 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2058 5236698 133 µM -0.689601327441335 0.258926354394325 no 2491 0.245222466187421 814 766665 SGTC_774 k060-0086 136 µM -0.689979770191211 0.258805627184496 no 2492 0.245103454611002 834 5911235 SGTC_2384 9036245 200 µM -0.690287700329772 0.258707415736104 no 2493 0.245006640562506 806 6462766 SGTC_1797 st048695 56.8 µM -0.692411730798446 0.258030501866583 no 2494 0.24433940050914 848 592262 YIL048W NEO1 SGTC_2456 5770359 74.46 µM -0.695313076600044 0.257107349568284 no 2495 0.243429560522559 855 3118787 SGTC_374 0880-0231 82.3 µM -0.696943898961251 0.2565892083968 no 2496 0.242918951764787 839 6833587 SGTC_138 0850-0259 40.9225 µM -0.697410683961916 0.256441002698388 no 2497 0.242772908612462 827 6813004 SGTC_1371 2421-0008 32.7 µM -0.698968646206475 0.255946667869643 no 2498 0.242285812722207 838 2827552 SGTC_1876 myriocin 605 nM -0.700219793205233 0.255550044498824 no 2499 0.241895026210136 853 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_71 0417-1750 47.813 µM -0.702136968766788 0.254942908372302 no 2500 0.241296874661163 814 6811472 SGTC_1199 1638-0010 4.46 µM -0.703483906187427 0.25451680860828 no 2501 0.240877116436468 837 3111136 SGTC_1479 0549-0158 134 µM -0.704108747459236 0.254319268642493 no 2502 0.240682526495785 838 5440202 SGTC_2335 9018011 154.17 µM -0.704852991628185 0.254084085057931 no 2503 0.240450863439486 824 6458208 SGTC_216 k038-0035 28.382 µM -0.705420830470715 0.253904722890732 no 2504 0.240274192292315 840 4444231 YPR107C YTH1 SGTC_2140 5586273 200 µM -0.706878269176743 0.253444668854516 no 2505 0.239821064724624 835 854421 SGTC_2513 baicalein 25.65 µM -0.71034235608705 0.252352958175346 no 2506 0.238745929966364 852 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1725 st036284 20.55 µM -0.710856948448028 0.252190995578696 no 2507 0.238586443258323 837 707914 SGTC_1408 3909-7976 48.8 µM -0.713247214806581 0.25143940339738 no 2508 0.237846397254369 845 24152374 SGTC_1995 st072814 61.1 µM -0.713437498728578 0.251379621685935 no 2509 0.237787537940241 840 5769371 SGTC_265 mycophenolic acid 32.932 µM -0.713638902669282 0.251316354571333 no 2510 0.23772524764552 849 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2931 9014674 55.67 µM -0.713707014092205 0.251294960603016 no 2511 0.23770418414188 857 2996810 SGTC_2222 6885208 172.143 µM -0.714633283622423 0.251004112640394 no 2512 0.237417836326344 830 609514 SGTC_2251 lansoprazole 556 µM -0.71484782377035 0.250936772604305 no 2513 0.237351540209434 839 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2204 7233102 200 µM -0.715444687438221 0.250749478864666 no 2514 0.237167153893203 834 2172480 SGTC_735 3076-0345 636 µM -0.715504239482942 0.25073079570261 no 2515 0.237148761075536 834 2888990 SGTC_180 1486-1293 102.781 µM -0.716805454007664 0.250322751967868 no 2516 0.236747072979377 835 4140536 SGTC_2749 bexarotene 57.39 µM -0.717708438211864 0.250039795076539 no 2517 0.236468539644206 850 82146 An retinoic acid receptor inhibitor. SGTC_2475 5812728 15.03 µM -0.718269163878733 0.249864172917854 no 2518 0.236295669745706 838 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1988 st071872 53.4 µM -0.718882652960985 0.249672100024287 no 2519 0.236106612801971 831 16414116 SGTC_3343 9148379 18.9835 µM -0.719211287375313 0.249569242498305 no 2520 0.236005372884323 827 1955036 SGTC_892 0929-0076 29 µM -0.722643431123779 0.248496380812696 no 2521 0.234949489056273 844 5751038 SGTC_3071 9117417 49.47 µM -0.723921919791565 0.248097364250475 no 2522 0.234556835985267 849 45595590 YGL055W OLE1 SGTC_548 1436-0017 110 µM -0.725125065245715 0.247722174710345 no 2523 0.234187654294146 834 9677137 SGTC_743 1275-0778 158 µM -0.725198733571175 0.247699211786979 no 2524 0.234165059839496 849 2849257 YMR203W TOM40 SGTC_1390 3413-2614 145 µM -0.72571494377508 0.247538337413293 no 2525 0.23400676937889 863 3421432 SGTC_3131 9127911 49.47 µM -0.726813345228244 0.247196211841168 no 2526 0.233670153378254 828 45595681 SGTC_2988 9073640 71.4286 µM -0.727212269653127 0.247072019125597 no 2527 0.233547965525128 843 9102229 SGTC_1923 st058458 19.1 µM -0.729269151398977 0.246432203031211 no 2528 0.232918519242078 866 3534982 SGTC_108 0509-0257 621.132 µM -0.729349643001012 0.246407183282788 no 2529 0.232893906402897 854 536624 SGTC_432 NS 1619 61.3 µM -0.729396020150863 0.246392768178185 no 2530 0.232879725786625 848 4552 A K+/calcium channel activator. SGTC_1266 0828-0227 32.9 µM -0.729643490595654 0.246315856207656 no 2531 0.232804065524118 864 3913820 SGTC_1137 ixabepilone 100 µM -0.729852906739069 0.246250781285336 no 2532 0.232740050446823 843 154225 A novel microtubule stabilizer. SGTC_1861 st057647 17.4 µM -0.731325010477613 0.24579359335342 no 2533 0.232290328685737 827 688668 SGTC_1375 2910-0797 186 µM -0.731528335486813 0.245730482998496 no 2534 0.232228251738108 854 742508 SGTC_3171 9103192 49.47 µM -0.731665977703718 0.245687764963097 no 2535 0.232186233576082 847 13018434 SGTC_1293 1000-1278 195 µM -0.731949840343166 0.24559967919168 no 2536 0.232099591937536 861 678847 SGTC_3223 9129970 49.47 µM -0.732889946011225 0.245308074977572 no 2537 0.231812777834427 869 17248386 SGTC_2105 5350118 200 µM -0.734506747434704 0.244807007246575 no 2538 0.231319974671224 855 2133313 SGTC_1037 k284-1091 78.7 µM -0.735342420382364 0.244548237487925 no 2539 0.231065489719105 840 3334711 SGTC_2515 chrysin 20.77 µM -0.736516655519586 0.244184879585451 no 2540 0.230708167637072 842 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1558 st069300 45.6 µM -0.737371507727212 0.243920535452336 no 2541 0.230448228696215 838 24208000 SGTC_567 1080-0542 68.4 µM -0.740520603263906 0.242948080823284 no 2542 0.229492082140618 816 5950415 SGTC_1353 1498-1206 8.11 µM -0.740582821664162 0.242928888658092 no 2543 0.229473213452642 827 6756808 SGTC_2451 5856223 45.7 µM -0.741940723237233 0.242510228657201 no 2544 0.22906162549311 847 2179896 SGTC_1173 0443-0020 122 µM -0.742608739226953 0.2423044135096 no 2545 0.228859297991404 851 5331295 SGTC_1124 fisetin 1.16336 µM -0.74352673130578 0.242021735436457 no 2546 0.228581421876834 855 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2675 theaflavin digallate 100 µM -0.744501087541002 0.241721896870375 no 2547 0.228286691759301 857 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_636 0kpi-0074 126 µM -0.7461072905338 0.24122806060848 no 2548 0.227801302806077 855 616434 SGTC_2358 9037157 4 µM -0.747650732989221 0.240754037521577 no 2549 0.227335427574365 853 2388925 SGTC_3269 9137823 49.47 µM -0.748176952155537 0.240592540683183 no 2550 0.227176715501885 816 17682936 SGTC_1134 3477-0009 42.5 µM -0.748931491380694 0.240361075293028 no 2551 0.226949249221337 841 3973534 SGTC_1483 3453-0561 55.9 µM -0.749211629284376 0.240275169989001 no 2552 0.226864830486037 873 4546991 SGTC_407 eburnamonine 100 µM -0.751949225846528 0.239436557272818 no 2553 0.226040796735322 846 3195 SGTC_973 1325-0077 65.9 µM -0.752188570265169 0.239363314538829 no 2554 0.225968833076804 860 2835149 SGTC_1399 3562-5772 25 µM -0.754815843592558 0.238560137205134 no 2555 0.225179743075623 857 23847490 SGTC_1712 st032288 53.4 µM -0.756283935581551 0.238111973645645 no 2556 0.22473948879062 858 2883011 SGTC_565 1418-0001 44.5 µM -0.756503387337811 0.238045021401317 no 2557 0.224673721132504 870 2862145 SGTC_791 1348-1292 225 µM -0.757688179923007 0.237683732904474 no 2558 0.224318838389436 873 5437054 SGTC_61 0978-8327 98.565 µM -0.759609238736041 0.237098568613213 no 2559 0.223744097537117 872 6150059 YHR072W ERG7 SGTC_2439 5492030 7.2 µM -0.761138383395027 0.236633349776807 no 2560 0.223287208263862 861 5722370 SGTC_1132 3456-3614 2.5 µM -0.762476559110902 0.236226642689216 no 2561 0.222887814150096 872 3125502 SGTC_5 0352-0601 109.883 µM -0.763970525966496 0.235773041717022 no 2562 0.222442403564754 849 762456 SGTC_381 3461-2219 42.7 µM -0.764074094517654 0.235741613853217 no 2563 0.222411544512207 871 2883159 SGTC_1218 1348-1416 30.7 µM -0.764305795958448 0.23567131244587 no 2564 0.2223425161146 847 6787668 SGTC_1340 1486-1359 257 µM -0.768446457030489 0.234416930456745 no 2565 0.221110994558097 844 4309068 SGTC_2083 5306046 65.942 µM -0.769307679959407 0.234156494362832 no 2566 0.220855339560366 856 539837 SGTC_293 4049-0273 38.5 µM -0.773226066030859 0.232973589066046 no 2567 0.219694301173869 846 1380311 SGTC_1539 benzyladenosine 56 µM -0.773394669855447 0.232922764544143 no 2568 0.219644421741868 851 92208 A nucleotide analog. SGTC_1329 1447-1697 50.6 µM -0.775774572856888 0.232206015722387 no 2569 0.218941049881055 870 2840515 SGTC_990 3985-0011 41.3 µM -0.775811145592301 0.232195010796799 no 2570 0.218930251057314 868 5399565 YGL099W LSG1 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.77798031251083 0.231542816606484 no 2571 0.218290309812939 896 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1388 3346-4487 254 µM -0.778795120911869 0.231298095723478 no 2572 0.218050206156487 883 3345614 SGTC_1677 st019204 53.9 µM -0.779213202207036 0.231172584532847 no 2573 0.217927067178268 868 3945625 SGTC_2702 st077768 96.8 µM -0.779381027787472 0.23112221270588 no 2574 0.217877648191494 842 6484119 SGTC_2381 9035592 200 µM -0.781299706295478 0.230546768517477 no 2575 0.217313121416639 876 4749657 SGTC_244 nsc-207895 1.295 µM -0.781341227214858 0.23053432454796 no 2576 0.217300914191359 825 42640 SGTC_2142 5622915 118.518 µM -0.781597368611239 0.230457566347601 no 2577 0.217225616915607 869 5322196 SGTC_3031 9088762 49.47 µM -0.782959908795516 0.2300494925079 no 2578 0.216825327621229 875 205253 SGTC_1460 k062-0059 9.15 µM -0.784317048618067 0.229643438298753 no 2579 0.21642704912612 853 1373085 SGTC_322 k048-0136 19.3 µM -0.784801671640805 0.229498537149344 no 2580 0.21628492993434 876 6823282 SGTC_3062 9077494 49.47 µM -0.784839118579073 0.229487342735222 no 2581 0.216273950599095 794 16459633 SGTC_1360 1598-0022 39.8 µM -0.784949253278294 0.229454420764013 no 2582 0.216241661290245 873 761525 SGTC_1884 5633444 25 µM -0.785005988453745 0.229437462257234 no 2583 0.216225028751688 862 5724239 SGTC_625 k213-0058 121 µM -0.786003684470553 0.229139359349591 no 2584 0.215932664294689 865 3655420 SGTC_306 1672-3436 11.6 µM -0.78601170319421 0.22913696430491 no 2585 0.215930315419234 874 6797378 SGTC_3332 9141069 11.198 µM -0.786280474731977 0.229056695332613 no 2586 0.215851594388542 867 17332883 SGTC_3119 9125183 49.47 µM -0.786456508371059 0.22900413120566 no 2587 0.215800044560641 842 22695334 SGTC_1243 0416-0003 5.65 µM -0.786808233441595 0.228899125409041 no 2588 0.215697066491751 870 2141977 SGTC_1825 st052143 62.6 µM -0.788555590820824 0.228377861189259 no 2589 0.215185897686933 873 674173 SGTC_1038 k292-0204 154 µM -0.789557310545764 0.228079333499641 no 2590 0.214893173759772 870 4454212 SGTC_1394 3474-0001 65.7 µM -0.790006034644726 0.227945678107079 no 2591 0.214762122028769 846 5017666 YIL048W NEO1 SGTC_825 1988-2224 89.6 µM -0.790772032212459 0.227717622585691 no 2592 0.214538516595512 865 1180859 SGTC_2802 7925815 54.55 µM -0.791843066822819 0.227398965787816 no 2593 0.214226093602696 874 1262923 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.7938616215817 0.226799083899735 no 2594 0.21363799710138 869 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3083 9117465 49.47 µM -0.795458131840124 0.22632525982765 no 2595 0.213173528153429 868 16420915 SGTC_2108 5365811 200 µM -0.795644263803633 0.226270054631093 no 2596 0.213119415582937 859 780283 SGTC_538 2922-0838 53.3 µM -0.798475773432526 0.225431191007535 no 2597 0.212297223295102 891 777039 SGTC_1075 aripiprazole 15.2 µM -0.798574668093925 0.225401924309547 no 2598 0.212268540557631 865 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1915 st067105 30.6 µM -0.798723190322245 0.225357974965332 no 2599 0.212225468432331 864 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1183 1254-0324 198 µM -0.799663428334327 0.225079860915756 no 2600 0.211952913677738 854 5799357 SGTC_423 5-fluorouracil 457 µM -0.800205891173097 0.224919493735163 no 2601 0.21179575856206 867 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2820 7989630 71.43 µM -0.801344814410782 0.224583007014009 no 2602 0.21146602681662 819 2984098 SGTC_857 0438-0306 1.35 µM -0.802787648550152 0.224157142338449 no 2603 0.211048741196925 852 4686136 SGTC_706 4262-0057 46.9 µM -0.803778128486438 0.223865059498941 no 2604 0.210762561660791 879 883298 SGTC_2825 7998094 58.44 µM -0.804998108408355 0.223505596822863 no 2605 0.210410385677743 869 2987815 SGTC_1969 st069479 40.1 µM -0.805102755984647 0.223474778089556 no 2606 0.210380192782015 874 3895485 SGTC_2102 5377816 72.7585 µM -0.806372459868971 0.22310104268573 no 2607 0.210014060795555 861 1379702 SGTC_2974 9094440 9.66 µM -0.81049574697215 0.221889816899739 no 2608 0.208827654216252 879 25236134 SGTC_285 1486-1325 46 µM -0.810559909022696 0.221870998860248 no 2609 0.208809223922512 878 22310230 SGTC_2854 9024559 71.43 µM -0.81208100454592 0.221425144918161 no 2610 0.208372576050571 886 3163529 SGTC_2279 7948423 32.93 µM -0.812923014190352 0.221178560783256 no 2611 0.208131099307248 858 1247112 SGTC_686 1319-0111 510 µM -0.81333284080084 0.221058599139608 no 2612 0.208013626471681 917 4562600 SGTC_2403 6032726 181.2 µM -0.814780580554165 0.220635124867008 no 2613 0.207598959341818 889 2881040 SGTC_1430 4049-0248 69.1 µM -0.817165925598576 0.219938408945958 no 2614 0.206916806133484 870 22774488 SGTC_420 mitomycin C 81.9 mM -0.818020243965009 0.21968918546597 no 2615 0.206672813959899 852 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_540 1187-0821 17.3 µM -0.818139544802624 0.219654395692112 no 2616 0.206638755363662 878 847520 SGTC_1129 3453-1384 223 µM -0.819658180808339 0.219211816966791 no 2617 0.206205498137382 899 1084452 SGTC_2405 ticlatone 3.52 µM -0.820138968120709 0.219071807194257 no 2618 0.206068444875693 912 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_633 0437-0093 97.7 µM -0.820433726893217 0.218985996109324 no 2619 0.205984447637372 873 2831118 SGTC_2157 5649910 96.377 µM -0.823209919771825 0.218178731338298 no 2620 0.205194314382825 890 2858091 SGTC_1611 st001856 99.4 µM -0.824220901023231 0.217885183486202 no 2621 0.204907026557565 889 647478 SGTC_1365 1672-3266 55.4 µM -0.824546997393408 0.217790546962951 no 2622 0.204814411663733 866 6415873 SGTC_1220 1838-0075 193 µM -0.826088179237472 0.217343601082964 no 2623 0.204377036333054 863 5529645 SGTC_2298 7976326 193.81 µM -0.826289105759689 0.217285371033327 no 2624 0.204320055958078 874 2235818 SGTC_632 0781-2353 4.65 µM -0.826885049363507 0.217112715000498 no 2625 0.204151109068643 903 6811515 YHR007C ERG11 SGTC_2995 9067767 71.4286 µM -0.830564664975492 0.216048418529293 no 2626 0.203109801564429 881 11673567 SGTC_1665 st014639 11.4 µM -0.831223705668102 0.215858116416318 no 2627 0.202923632693652 870 981133 YIL048W NEO1 SGTC_1458 k015-0034 6.33 µM -0.831505430817541 0.2157767961687 no 2628 0.202844080773562 873 3598957 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.832647758079067 0.215447244285585 no 2629 0.202521707973997 904 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1832 st054113 55 µM -0.834084093755693 0.215033288069204 no 2630 0.202116798898206 884 1251267 SGTC_2121 5257820 149.641 µM -0.834192006442133 0.215002205975456 no 2631 0.202086397434223 873 791256 SGTC_1525 8-methoxypsoralen 92.5 µM -0.834431274929626 0.214933298773221 no 2632 0.202018999807247 895 4114 Related to psoralen; DNA damaging agent. SGTC_2002 4023503 131 µM -0.835289178499713 0.214686335622753 no 2633 0.201777454427711 892 4736863 YCR052W RSC6 SGTC_2129 girgensonine 121.053 µM -0.836682110344281 0.214285706290964 no 2634 0.201385638761824 886 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1176 0848-0131 83.3 µM -0.837519238258131 0.214045144362331 no 2635 0.201150383870187 888 6769040 SGTC_844 0330-0132 15.3 µM -0.838228369225964 0.213841487403013 no 2636 0.20095122846781 873 2828079 SGTC_2490 carminic acid 95.39 µM -0.84044521013572 0.213205555929493 no 2637 0.200329404693951 878 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_185 k048-0037 25.491 µM -0.843685171819701 0.212278114765312 no 2638 0.199422677859993 865 6827589 SGTC_1556 plumbagin 1.48 µM -0.843685236969654 0.212278096139834 no 2639 0.199422659652182 859 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2119 5528445 120.635 µM -0.844443001525396 0.212061526268538 no 2640 0.199210950784309 902 791935 SGTC_2245 6637752 200 µM -0.844621169845843 0.212010624350649 no 2641 0.199161192699033 898 681890 SGTC_3019 9081971 49.47 µM -0.844774946764534 0.211966696696443 no 2642 0.199118252559843 895 16451803 SGTC_3353 9151644 39.2805 µM -0.845648975385727 0.211717124296569 no 2643 0.198874297762678 892 4909158 SGTC_2032 5185112 25.99 µM -0.84710025824965 0.211303101290978 no 2644 0.198469620598432 846 5718189 SGTC_2401 5128683 200 µM -0.847218448976026 0.211269404655483 no 2645 0.198436686069262 905 708373 SGTC_614 0462-0418 107 µM -0.848121710065872 0.211011985393291 no 2646 0.198185096058034 857 5188303 SGTC_1579 chlormadinone acetate 49.4 µM -0.848828328513381 0.2108107353165 no 2647 0.197988412255926 898 45114258 A steroidal progestin. SGTC_1398 3558-0053 112 µM -0.84923594717482 0.210694693771457 no 2648 0.197875007224026 868 4532369 SGTC_3081 9117243 49.47 µM -0.850969932584164 0.210201478908276 no 2649 0.197393027681281 887 45595589 SGTC_2757 clomiphene 4.22 µM -0.852309123097331 0.209821024036631 no 2650 0.197021271906475 897 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2220 6782180 200 µM -0.853558977736164 0.209466314336985 no 2651 0.196674698122585 874 833803 SGTC_3308 9128332 17.569 µM -0.853987048192069 0.209344908770089 no 2652 0.196556082869886 857 17332805 YDL196W YDL196W SGTC_1034 k072-0165 12.7 µM -0.854997309992559 0.209058551471444 no 2653 0.196276318476178 905 5835461 SGTC_3016 9080866 49.47 µM -0.856327194678606 0.208681949409603 no 2654 0.195908411539304 887 17066299 SGTC_1740 st038286 13.222 µM -0.85684175304358 0.208536342072281 no 2655 0.195766173502105 881 716786 SGTC_154 3389-1638 511.116 µM -0.857935895424082 0.208226925926729 no 2656 0.195463930971411 923 5238686 SGTC_438 sphingosine 6.67 µM -0.861194769643677 0.207306944512422 no 2657 0.19456539013557 894 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2246 7293507 91.5585 µM -0.861881312627701 0.207113440113776 no 2658 0.194376416709927 874 887656 SGTC_2765 myclobutanil 7.74 µM -0.86199263699958 0.207082073043946 no 2659 0.194345784808342 906 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_950 1165-0508 94.1 µM -0.863479532270786 0.206663390743923 no 2660 0.193936934055582 901 6148369 SGTC_92 0063-0024 660.874 µM -0.864938775714831 0.206252982470994 no 2661 0.193536196753822 904 3594437 SGTC_2435 5706476 10.6 µM -0.864980504264976 0.206241253538334 no 2662 0.193524744696099 863 5725375 SGTC_475 α-linolenic acid 10 µM -0.865092283612474 0.206209836890849 no 2663 0.193494069809256 872 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_512 prima-1 270 µM -0.867221446104846 0.205611957395785 no 2664 0.192910343895058 887 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3273 9137859 49.47 µM -0.867429429873045 0.205553609731345 no 2665 0.19285338130157 935 2377234 SGTC_691 1548-0686 185 µM -0.868928221008185 0.205133430345568 no 2666 0.192443196267896 875 46495133 SGTC_1440 4100-1550 40 µM -0.870542110822388 0.204681554761596 no 2667 0.192002108273784 895 742806 SGTC_2539 epi(13)torulosol 80 µM -0.87089040720823 0.204584112444019 no 2668 0.191906997536872 879 6708597 SGTC_2649 anisomycin 9.56 µM -0.871062291260182 0.204536034894037 no 2669 0.191860071076707 890 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_422 cantharidin 155 µM -0.871343245017238 0.204457464022671 no 2670 0.191783382372545 903 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_401 neomycin 50 µM -0.872647912108536 0.204092839339173 no 2671 0.191427508459939 866 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2263 7948595 193.29 µM -0.8752627399357 0.203363221793755 no 2672 0.190715481356424 876 2971371 SGTC_1185 1319-0113 81.3 µM -0.875566202528285 0.203278647285995 no 2673 0.190632952783888 896 4672763 SGTC_2873 9040596 71.43 µM -0.877077120675884 0.202857869504746 no 2674 0.190222375406244 904 6463863 SGTC_1648 st011736 69.8 µM -0.877614682161391 0.202708288806348 no 2675 0.190076429405736 907 2855514 SGTC_3117 9124945 49.47 µM -0.877913577000132 0.202625147493078 no 2676 0.18999531031475 882 17592065 SGTC_3028 9087778 49.47 µM -0.877980835166485 0.20260644160792 no 2677 0.18997705959966 871 17217395 SGTC_343 4130-2827 29.8 µM -0.878286082760442 0.202521558920837 no 2678 0.189894243249236 887 1118244 SGTC_1367 1812-0510 76.9 µM -0.879860476501998 0.202084092132263 no 2679 0.189467448985569 884 1142582 YDR527W RBA50 SGTC_172 1112-0046 2.638 µM -0.880366425750105 0.201943627379733 no 2680 0.18933041924523 925 2802135 YIL048W NEO1 SGTC_1189 1431-2119 7.28 µM -0.880878222940631 0.201801598563692 no 2681 0.189191867750506 890 3107275 SGTC_1782 st039423 80.636 µM -0.88227398094944 0.201414565931391 no 2682 0.188814331663394 910 2068169 SGTC_406 estrone 100 µM -0.884278395055107 0.200859536604649 no 2683 0.188272974041941 883 5870 A steroid. SGTC_988 1497-1057 103 µM -0.88582590081746 0.200431655291184 no 2684 0.18785567523813 888 3533044 SGTC_937 3122-0005 46.7 µM -0.886407047533883 0.200271111250709 no 2685 0.187699111451412 872 759535 SGTC_3209 9113616 49.47 µM -0.891291589057986 0.198924794150129 no 2686 0.186386379886883 898 16649353 SGTC_2160 5660466 132.927 µM -0.891916375382063 0.198752979807878 no 2687 0.186218878380809 923 2859134 SGTC_582 0987-0078 156 µM -0.893283958749312 0.198377210932226 no 2688 0.185852563088293 913 1625765 SGTC_2716 st080858 38.6235 µM -0.896227512106686 0.197569870831898 no 2689 0.185065632350031 882 5296050 SGTC_2918 7977171 22.06 µM -0.897457880470635 0.197233002268071 no 2690 0.184737319511471 881 2236483 SGTC_1706 st031321 9.9705 µM -0.89817409434334 0.197037066685118 no 2691 0.184546371057662 897 6103185 SGTC_529 4076-0302 30.3 µM -0.903362914472736 0.19562107571735 no 2692 0.183166657870898 915 5816522 SGTC_2470 5664817 21.68 µM -0.903541840690802 0.195572358515991 no 2693 0.183119196226496 908 2859561 SGTC_1406 3909-7906 11.9 µM -0.905409619339775 0.195064248356619 no 2694 0.182624210769289 885 X1406 SGTC_2486 5283202 22.39 µM -0.90581476147698 0.194954139569163 no 2695 0.182516953245475 903 1377751 SGTC_2723 salbutamol 83.58 µM -0.906684544909152 0.194717879115048 no 2696 0.182286819303386 894 9884233 β2-adrenoceptor agonist SGTC_2572 astragaloside iv 100 µM -0.906715729535003 0.19470941162857 no 2697 0.182278571605564 899 45006101 An anti-inflammatory agent. SGTC_2064 5220758 200 µM -0.90768359524673 0.194446720759619 no 2698 0.182022706801395 905 788518 SGTC_798 1287-0182 476 µM -0.908171362995545 0.194314416283937 no 2699 0.181893845753028 930 1649755 SGTC_44 0929-0055 61.211 µM -0.908613848327282 0.19419444185922 no 2700 0.181776997020066 906 1379590 SGTC_411 enrofloxacin 100 µM -0.908964478576147 0.194099404851435 no 2701 0.181684438153233 900 71188 A bacterial gyrase inhibitor. SGTC_1986 st071812 45 µM -0.91070818277377 0.193627201350398 no 2702 0.181224575737138 913 11838594 SGTC_113 0099-0221 2.5 µM -0.911253892566939 0.193479564557103 no 2703 0.181080807065732 890 89219 SGTC_228 caffeine 993.056 µM -0.911397977451863 0.193440595171422 no 2704 0.181042859453188 889 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3146 9095609 49.47 µM -0.911604637669097 0.193384709939938 no 2705 0.180988440084552 913 17173999 SGTC_2764 methyldopa 94.69 µM -0.911947754198963 0.193291945834501 no 2706 0.180898110622397 902 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.91265176636154 0.193101695950964 no 2707 0.180712859621072 911 803109 SGTC_3249 9135183 49.47 µM -0.913206581245802 0.192951845218311 no 2708 0.180566951641995 886 4902779 SGTC_479 n-linoleoylglycine 10 µM -0.914317494927657 0.192652010524544 no 2709 0.180275020190456 914 6433346 An anti-infammatory. SGTC_2089 5281248 129.67 µM -0.915008099680683 0.192465760471887 no 2710 0.180093689004755 902 2737878 SGTC_1317 1273-0028 910 nM -0.915036294422903 0.192458158936531 no 2711 0.180086288381868 893 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_870 0573-2213 57.6 µM -0.915078583140499 0.192446757893141 no 2712 0.1800751886968 884 3916321 SGTC_938 3126-1755 342 µM -0.916309834653546 0.192114993394125 no 2713 0.179752205617479 889 1777771 SGTC_738 1315-0003 72.4 µM -0.916349386755165 0.192104341763379 no 2714 0.179741836309157 932 6251474 SGTC_832 4083-0019 164 µM -0.917262651582138 0.191858494286895 no 2715 0.179502511724872 910 1990758 SGTC_954 1189-0853 2.85 µM -0.917265682001179 0.191857678830176 no 2716 0.179501717925399 896 2828194 SGTC_3127 9126946 49.47 µM -0.919695666780912 0.191204476366699 no 2717 0.178865908847346 888 27243249 SGTC_939 1165-0479 45.3 µM -0.920767997892067 0.19091665791007 no 2718 0.178585783180368 896 1377347 SGTC_562 3772-2733 112 µM -0.923596002358387 0.190158884536001 no 2719 0.177848347993154 906 2876874 YIL048W NEO1 SGTC_2395 5646831 180.19 µM -0.925096212245692 0.189757649517226 no 2720 0.177457931581277 930 6808628 SGTC_1812 st052057 4.327 µM -0.926199331771491 0.189462949779661 no 2721 0.177171199880426 925 3645418 SGTC_1251 0490-5699 265 µM -0.927410393812469 0.189139737600641 no 2722 0.176856748080579 905 3883818 SGTC_1040 k898-0338 155 µM -0.928858352517399 0.188753747644924 no 2723 0.17648124945866 896 20969351 SGTC_687 k029-0044 34.9 µM -0.929590928177357 0.188558646189231 no 2724 0.176291463126225 899 5829338 SGTC_1573 oleylamine 1.06 µM -0.930388887255278 0.18834627319376 no 2725 0.176084885105719 916 5356789 An amine of the fatty acid oleic acid. SGTC_74 000s-0487 160.283 µM -0.931675389566688 0.188004187612188 no 2726 0.175752154402216 904 677548 SGTC_1142 3253-1408 9.78 µM -0.932773563042284 0.187712482994127 no 2727 0.175468446888825 922 256655 SGTC_2507 purpurin 79.67 µM -0.933178297745514 0.187605045041228 no 2728 0.175363958994462 917 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_227 fluconazole 33.516 µM -0.934275761434193 0.187313911491396 no 2729 0.175080832029526 921 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2176 5809774 33.9695 µM -0.934922280646327 0.187142534642489 no 2730 0.174914176878347 873 2870539 SGTC_1001 4048-4355 44.4 µM -0.935900193921192 0.186883497461781 no 2731 0.17466228867275 908 21824233 SGTC_532 1548-0774 215 µM -0.93617846061472 0.186809828612116 no 2732 0.174590655617112 943 5932993 SGTC_2007 4011539 71.82 µM -0.938721150678233 0.186137504779447 no 2733 0.173936965609374 906 45595301 SGTC_1200 1643-0193 18.4 µM -0.940236652261259 0.18573749860502 no 2734 0.173548092577758 914 5403974 SGTC_991 3996-0057 64.7 µM -0.943465491085315 0.184887048888358 no 2735 0.172721429216897 904 715343 SGTC_2643 anethole 100 µM -0.943485624181491 0.184881753598931 no 2736 0.172716282528698 939 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_600 1495-0418 41.6 µM -0.943644427142982 0.184839989474798 no 2737 0.172675690643052 929 5377768 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.944490597294576 0.184617551222376 no 2738 0.172459502255117 899 3256 An antibiotic and ribosome inhibitor. SGTC_1324 1418-0026 34.4 µM -0.944739237452959 0.184552221220801 no 2739 0.172396009900454 932 1372513 SGTC_1647 st011722 22.4 µM -0.944810251284551 0.184533565033552 no 2740 0.172377878659369 901 2854783 SGTC_1264 0783-0040 158 µM -0.945224154026109 0.184424851150123 no 2741 0.172272225279808 906 2855798 SGTC_2927 9011802 47.9 µM -0.946021712930507 0.184215480198468 no 2742 0.172068755846022 916 43912568 SGTC_1681 tripelennamine 100 µM -0.946544858910392 0.184078227050155 no 2743 0.171935376674956 890 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_750 4073-0104 132 µM -0.947972410685636 0.183704017008879 no 2744 0.171571749823589 875 22330957 SGTC_1554 st069299 38.7 µM -0.949256298712505 0.183367871256174 no 2745 0.17124513710019 905 24207999 SGTC_3312 9133330 71.43 µM -0.950000448323655 0.183173214721987 no 2746 0.171056012407821 937 17617324 SGTC_517 1365-0151 113 µM -0.950115410588065 0.183143154100619 no 2747 0.171026806810762 919 768657 SGTC_1289 0976-0073 69.1 µM -0.951034422494953 0.182902959198237 no 2748 0.170793451039093 921 3391136 SGTC_1481 3346-2004 36 µM -0.951902613732865 0.182676227575374 no 2749 0.170573186934031 925 2770522 SGTC_1419 3993-2473 62.6 µM -0.952265901809668 0.182581405540699 no 2750 0.17048107307879 925 704026 SGTC_858 0438-0351 2.77 µM -0.953656362335219 0.182218764665492 no 2751 0.170128807884654 921 2799119 SGTC_2313 7726885 200 µM -0.954453732961024 0.182011008615659 no 2752 0.169927009209198 918 726423 SGTC_1940 st075990 51.1 µM -0.961164389087988 0.180268410716408 no 2753 0.168234759313508 951 1084979 SGTC_382 3229-0966 23.2 µM -0.962683060054739 0.179875505580348 no 2754 0.167853300188918 925 5722370 SGTC_2299 7976368 114.88 µM -0.962909484675535 0.179816971918135 no 2755 0.167796474685709 929 2979718 SGTC_1514 1189-1591 158 µM -0.965118601170467 0.179246515014969 no 2756 0.167242705563218 937 767698 YMR146C TIF34 SGTC_1086 cerivastatin 2.18 µM -0.965714630634769 0.179092798381392 no 2757 0.167093498213523 884 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_405 ebelactone b 50 µM -0.967799706868913 0.178555707774391 no 2758 0.166572205121633 918 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2257 7960413 200 µM -0.969753702245615 0.178053303834725 no 2759 0.166084637607245 903 2974689 YIL048W NEO1 SGTC_2744 captopril 92.04 µM -0.971632737119266 0.177571014953619 no 2760 0.165616645068069 898 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2375 9072683 200 µM -0.974484816788746 0.176840553288945 no 2761 0.16490793715397 922 16798029 SGTC_3084 9116877 49.47 µM -0.974678293240531 0.176791069866416 no 2762 0.164859931793943 902 27241325 SGTC_3014 9081533 49.47 µM -0.975029906577251 0.176701163858004 no 2763 0.164772712697305 933 21367265 SGTC_2746 daunorubicin 9.88 µM -0.978001361164202 0.175942530539094 no 2764 0.164036825435617 884 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1660 st012960 28.1 µM -0.979725063506632 0.175503403844106 no 2765 0.163610925405135 914 24207266 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.980432367488454 0.175323413787961 no 2766 0.163436369536357 916 2724278 An inhibitor of dopamine biosynthesis. SGTC_881 0833-0569 170 µM -0.981363448241611 0.175086657005876 no 2767 0.163206772185981 926 5418700 SGTC_515 4092-1064 102 µM -0.981736312072138 0.17499190146319 no 2768 0.16311488563539 959 717353 SGTC_1184 1269-1718 139 µM -0.983282808877129 0.174599239078788 no 2769 0.162734134310563 904 5403821 SGTC_3255 9139072 49.47 µM -0.983899159328661 0.17444290101981 no 2770 0.16258254854549 909 17646060 SGTC_41 0478-0632 82.643 µM -0.988422292196283 0.173298324751456 no 2771 0.161472937193242 907 3750424 SGTC_685 1278-0033 54.9 µM -0.989550720777038 0.173013523464551 no 2772 0.161196883436377 926 3590572 SGTC_650 1328-0195 38 µM -0.989745698855549 0.17296434366064 no 2773 0.161149216079972 933 2780821 SGTC_793 0488-0545 106 µM -0.99038786918175 0.172802430432144 no 2774 0.160992286224958 929 292548 SGTC_918 glabranin 770.725 nM -0.99050593918711 0.172772671439291 no 2775 0.160963443821515 933 124049 Also referred to as licorice root. SGTC_1748 st037455 53.6035 µM -0.99129159240398 0.172574734412134 no 2776 0.160771608600538 931 580690 SGTC_576 1073-0113 22.7 µM -0.991573995725245 0.172503621222176 no 2777 0.160702689852878 945 5439563 SGTC_1374 2889-5571 141 µM -0.992055692870855 0.172382366131768 no 2778 0.160585179232945 903 2853281 SGTC_1466 k213-0079 57.5 µM -0.992928746877234 0.172162735445558 no 2779 0.160372339707527 946 3657981 SGTC_2560 caryophyllene 100 µM -0.993325161759203 0.172063069925889 no 2780 0.16027575965372 936 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_925 2064-1272 59.6 µM -0.994303533800175 0.171817248017487 no 2781 0.160037557905767 943 6815817 SGTC_2913 7966556 36.57 µM -0.994450082497852 0.171780446091919 no 2782 0.160001898012154 883 2976516 SGTC_2914 7968218 45.32 µM -0.995762222822459 0.171451160260874 no 2783 0.159682844685477 908 2977111 SGTC_2623 humulene 100 µM -0.996018448326309 0.171386906757411 no 2784 0.159620590820732 941 6187145 An anti-inflammatory. SGTC_131 0141-0277 33.849 µM -0.996229218301479 0.171334063647056 no 2785 0.15956939297299 952 1547771 SGTC_1708 st033234 31.827 µM -0.996386979457189 0.171294517438153 no 2786 0.159531078459396 919 674664 SGTC_945 3381-0768 11.3 µM -0.996868195386359 0.171173926421239 no 2787 0.159414245609578 931 1126236 YIL048W NEO1 SGTC_1327 1436-0082 2.18 µM -0.997640582031625 0.170980482578 no 2788 0.159226837513828 946 15992205 SGTC_493 zm226600 134 µM -0.998589352331797 0.170743055020007 no 2789 0.158996830121714 927 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1590 st077108 57.8 µM -1.00064975258352 0.17022817176391 no 2790 0.15849808390547 912 5489485 SGTC_2391 6285546 200 µM -1.00375085150363 0.169455100834428 no 2791 0.157749359800962 927 846083 SGTC_719 2810-4230 27.3 µM -1.00452936609526 0.169261379778402 no 2792 0.157561761961024 943 721079 SGTC_2187 6125751 200 µM -1.00464769334879 0.169231948362208 no 2793 0.157533261606385 940 874498 SGTC_2070 5230947 200 µM -1.00527989154954 0.16907475802742 no 2794 0.157381047471946 941 2835538 SGTC_2681 menadione 3.18 µM -1.00769131127792 0.168476041700086 no 2795 0.156801338741238 941 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1146 3579-1023 7 µM -1.01195274641178 0.167421334152637 no 2796 0.155780323766111 956 X1146 SGTC_1727 st034309 9.9045 µM -1.01448417894544 0.166796821937265 no 2797 0.155175887466411 957 870305 SGTC_2015 5119600 184 µM -1.01577394737597 0.166479210786681 no 2798 0.154868522477157 946 2828786 SGTC_2125 5246583 200 µM -1.01786578196941 0.165964918021479 no 2799 0.154370872531144 931 835267 SGTC_2899 9053889 58.44 µM -1.01806459298474 0.165916092370397 no 2800 0.154323630234473 919 6470052 SGTC_3351 9150312 21.596 µM -1.01863680294258 0.165775616140715 no 2801 0.154187712694452 929 4904905 SGTC_42 0133-0086 60.653 µM -1.02187838418932 0.164981267512207 no 2802 0.153419232158796 945 162923 Model of phenazepam hydroxylation. SGTC_1701 st028638 40.4 µM -1.02290156719356 0.164731049382625 no 2803 0.153177194222046 934 3490878 SGTC_1704 st028805 70.8 µM -1.02308251582689 0.164686824216672 no 2804 0.153134416463575 941 2876101 SGTC_1583 clindamycin 39.6 µM -1.0234659447043 0.164593136824978 no 2805 0.153043796862328 946 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1944 st076371 56.9 µM -1.02510650697463 0.164192670325635 no 2806 0.152656467790735 920 24208455 SGTC_3186 9110464 49.47 µM -1.02577929232104 0.164028624131414 no 2807 0.152497814505387 939 17018021 SGTC_767 0929-0023 86 µM -1.02777788039602 0.163541932920959 no 2808 0.15202716174132 941 1204563 SGTC_270 tamoxifen 5.46 µM -1.0279296096677 0.163505022522396 no 2809 0.15199147006049 967 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2591 skatole 100 µM -1.02816352641311 0.16344812940053 no 2810 0.151936456106767 940 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3196 9111891 49.47 µM -1.02894455101764 0.163258262108507 no 2811 0.151752865848687 958 18891510 SGTC_3320 9137005 35.139 µM -1.03030384985052 0.162928158078634 no 2812 0.151433696206193 933 4908713 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.0317731074238 0.162571839093183 no 2813 0.151089210085889 867 4000243 SGTC_3291 9121177 71.43 µM -1.03441163766144 0.161933226157973 no 2814 0.150471883081662 940 17015612 SGTC_11 0438-0307 1.3 µM -1.03506719830885 0.161774812266644 no 2815 0.150318764991277 952 4011476 SGTC_1618 st003135 44.5 µM -1.03614459630932 0.161514682331122 no 2816 0.150067344742397 947 1270615 SGTC_2737 bleomycin 30.5 nM -1.03817204873273 0.161025908537629 no 2817 0.149594981577521 939 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_534 k292-0788 63.4 µM -1.03840010247363 0.160970990301075 no 2818 0.149541910941229 949 4146317 SGTC_1932 st074806 40.9 µM -1.03924684007464 0.160767192107271 no 2819 0.149344975647711 933 17251235 SGTC_1982 st072467 71.9 µM -1.03941274396418 0.160727281050992 no 2820 0.149306409808094 947 3163533 SGTC_2834 9001755 58.44 µM -1.03974241950081 0.160647991090864 no 2821 0.149229793523913 946 2989575 SGTC_2174 5790901 200 µM -1.04130382258809 0.16027280655338 no 2822 0.14886728158691 947 786020 SGTC_1760 st045453 10.4495 µM -1.04155363345445 0.160212833487568 no 2823 0.148809337491921 951 3323419 YIL048W NEO1 SGTC_2987 9018338 71.43 µM -1.04300166221521 0.159865488590885 no 2824 0.148473761457162 924 5055682 SGTC_373 0844-0104 25.9 µM -1.04433419422078 0.159546283944673 no 2825 0.148165398884026 930 5375804 SGTC_84 0443-0269 128.823 µM -1.04494644404767 0.15939976102668 no 2826 0.148023861315595 906 6150058 SGTC_885 0865-0106 16.8 µM -1.04501737019982 0.159382792758259 no 2827 0.148007470730359 935 2793380 SGTC_3347 9188721 44.724 µM -1.04551831702023 0.159262980653253 no 2828 0.147891739678136 948 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1488 4013-0813 75.9 µM -1.04621469265866 0.159096525596565 no 2829 0.147730960425768 917 2910057 SGTC_2689 tacrolimus 100 µM -1.04809200747886 0.158648357962684 no 2830 0.147298109165416 925 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2325 6158266 200 µM -1.0514362855948 0.157852037867807 no 2831 0.146529128926511 939 3623240 SGTC_3068 9116768 49.47 µM -1.05298361462983 0.157484486604439 no 2832 0.146174250912398 938 41904888 SGTC_126 0417-1624 672.48 µM -1.05646176406713 0.156660344550279 no 2833 0.145378650386333 938 41912 YDL195W SEC31 SGTC_2522 biochanin a 4.94 µM -1.05667425229694 0.156610087980069 no 2834 0.14533013989519 938 5280373 A possible chelator. SGTC_1970 st070122 35.8 µM -1.05679022959408 0.156582662133018 no 2835 0.145303667184691 950 102928 SGTC_550 4123-0385 25.7 µM -1.05867072333795 0.156138411798519 no 2836 0.144874882773354 958 5731123 SGTC_866 0495-0101 262 µM -1.05873049109905 0.156124305814192 no 2837 0.144861268695652 928 635694 SGTC_1156 4092-0367 4.88 µM -1.05878971825083 0.156110328249228 no 2838 0.144847778609333 937 1357585 SGTC_2588 indole-3-carbinol 100 µM -1.05968526127048 0.155899081245457 no 2839 0.144643905109802 943 3712 Induces cell cycle arrest. SGTC_788 1182-0090 188 µM -1.06191110064273 0.155374851165626 no 2840 0.144138022588134 938 5715185 SGTC_541 4513-1321 94 µM -1.06208388590778 0.155334205461151 no 2841 0.144098802396372 912 747515 SGTC_1945 st075991 56.6 µM -1.06383221254024 0.154923326902178 no 2842 0.143702357928456 956 1084980 SGTC_1024 4507-0395 26 µM -1.06441743847101 0.154785952011873 no 2843 0.143569818705271 949 4201836 SGTC_1237 0330-0133 46.1 µM -1.06601340461286 0.154411726874782 no 2844 0.143208791218038 955 X1237 YHR072W ERG7 SGTC_3338 9144300 39.5675 µM -1.06736154034882 0.154096079907894 no 2845 0.142904304223307 933 4901274 SGTC_2369 9071472 200 µM -1.06741712833934 0.154083073933557 no 2846 0.14289175864031 943 17296037 SGTC_989 1501-0895 10.3 µM -1.0676153474894 0.15403670232479 no 2847 0.142847028871672 933 2830112 SGTC_1912 st060209 90.8 µM -1.06929599466895 0.153643900907322 no 2848 0.142468157428649 956 688787 SGTC_1976 st070609 63.5 µM -1.06955320773948 0.153583843552299 no 2849 0.14241023342972 920 682556 SGTC_2596 sinensetin 100 µM -1.07287370785536 0.152809927091728 no 2850 0.141663892066975 946 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_290 2043-6722 48.1 µM -1.07395925665561 0.152557477723018 no 2851 0.141420471433982 938 773758 YLR208W SEC13 SGTC_1468 k284-1086 134 µM -1.07837716527486 0.151532928901129 no 2852 0.140432736588923 941 15996457 SGTC_2810 7959871 45.46 µM -1.0792924639937 0.151321237073312 no 2853 0.140228685647696 932 2974535 SGTC_2903 5923464 63.88 µM -1.08079051403564 0.1509751901284 no 2854 0.139895154504893 949 2876576 SGTC_1966 st070145 16.1 µM -1.08159029498337 0.150790657941387 no 2855 0.139717309395283 955 3748532 SGTC_2526 patulin 37.61 µM -1.08363290895419 0.150320050616094 no 2856 0.13926379673718 951 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1074 carmofur 3.8 µM -1.08616733557991 0.149737494255513 no 2857 0.138702482950434 954 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.08659198060621 0.14964003402727 no 2858 0.138608585364679 973 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1730 st033808 45.1 µM -1.08663615609021 0.149629897748453 no 2859 0.138598819761083 946 1045166 SGTC_1749 st037932 54.2 µM -1.0882009876123 0.14927113512024 no 2860 0.138253194421854 973 594497 SGTC_115 0527-0192 112.043 µM -1.08825474684363 0.149258820170945 no 2861 0.138241331035037 957 4233931 SGTC_3151 9099821 49.47 µM -1.08839256133832 0.149227253277526 no 2862 0.138210921816054 963 17174189 SGTC_1195 1502-0147 41.1 µM -1.0888461051397 0.14912339895818 no 2863 0.138110878095888 932 817940 SGTC_2679 rapamycin 1 nM -1.09178154217111 0.148452398048208 no 2864 0.137464566947226 907 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1557 sumaresinolic acid 42.3 µM -1.09262478519557 0.14826001808395 no 2865 0.137279287946912 938 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2324 6149169 200 µM -1.0941077033578 0.147922105460227 no 2866 0.136953872140373 950 2888231 SGTC_1433 4060-0023 7.6 µM -1.09445851562723 0.147842241324393 no 2867 0.136876966060041 949 3840627 SGTC_3216 9129716 49.47 µM -1.09544486119443 0.147617849631624 no 2868 0.136660894717668 936 8056934 SGTC_1668 st014914 51.6 µM -1.09873340263328 0.146871361788579 no 2869 0.135942184177003 954 2839556 SGTC_3035 9091303 49.47 µM -1.0990818962127 0.146792403564018 no 2870 0.135866172858001 975 25237002 SGTC_2178 5812956 200 µM -1.09936699874625 0.146727829037064 no 2871 0.135804009659731 937 5403383 SGTC_1047 2043-3044 82 µM -1.10893358401433 0.144572085381236 no 2872 0.133729417271492 996 669592 SGTC_2371 9071574 200 µM -1.10913595794006 0.144526713905258 no 2873 0.133685767436186 981 45596039 SGTC_2790 5423970 71.43 µM -1.11235559330087 0.143806174131795 no 2874 0.132992644854656 951 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_970 1315-0089 19.5 µM -1.11263198842624 0.143744431315231 no 2875 0.132933258070908 941 6811083 YLR033W RSC58 SGTC_2278 7948257 134.34 µM -1.11291072953739 0.143682182556246 no 2876 0.132873385717495 944 1247028 SGTC_2086 5274770 176.623 µM -1.11382833346948 0.143477390806032 no 2877 0.132676419649671 932 689278 SGTC_1700 st030840 7.9285 µM -1.11480316040097 0.143260043940869 no 2878 0.132467390934954 957 5499307 SGTC_1471 k673-0312 37 µM -1.11569853357047 0.143060608056556 no 2879 0.132275599246011 955 24099884 SGTC_2252 omeprazole 400 µM -1.11840456637727 0.142459005462982 no 2880 0.131697122474921 942 4594 A proton pump inhibitor. SGTC_704 1310-0270 142 µM -1.12063472511819 0.141964486772453 no 2881 0.131221688771694 945 5718033 SGTC_2650 prasterone 100 µM -1.12236380167615 0.141581879537456 no 2882 0.130853894416907 935 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1116 jasmonic acid  1.58368 µM -1.1246629932575 0.141074201214304 no 2883 0.130365934531138 958 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.12774458543191 0.140395701421818 no 2884 0.129713901144219 962 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_106 0092-0003 11.579 µM -1.12813924783642 0.140308965646956 no 2885 0.129630558053394 952 1072148 SGTC_1366 1683-0113 21.9 µM -1.12887094014288 0.140148256404455 no 2886 0.129476140598884 970 708623 SGTC_578 3460-0051 92 µM -1.13066371139826 0.1397550199948 no 2887 0.129098330272509 985 2876744 SGTC_1474 0330-0125 5.35 µM -1.13272625591227 0.139303538744108 no 2888 0.128664614052594 997 X1474 SGTC_2302 7771753 200 µM -1.13303969999559 0.139235014277907 no 2889 0.128598790973126 948 2203047 SGTC_1874 staurosporine 7.6 µM -1.13341012465393 0.139154062417898 no 2890 0.12852103213718 949 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1050 3232-1156 69.3 µM -1.13355384577046 0.139122662520978 no 2891 0.12849087126405 963 700529 SGTC_2340 7987427 183.45 µM -1.13491023589539 0.138826558694999 no 2892 0.128206465359995 952 2239331 SGTC_1799 st045822 46.1415 µM -1.13517584807643 0.138768625087507 no 2893 0.128150823411118 919 3674992 SGTC_1207 2099-0101 141 µM -1.13706697843344 0.138356619983532 no 2894 0.127755143500031 946 5837381 SGTC_307 1501-1223 22.3 µM -1.13769608052931 0.138219747657041 no 2895 0.127623705315965 968 2830329 SGTC_1511 0906-3109 28.5 µM -1.14067949953879 0.137571909105659 no 2896 0.12700166033475 968 2882180 SGTC_2322 7413319 38.22 µM -1.14351662665282 0.136957762898681 no 2897 0.126412077742587 929 1840400 SGTC_1273 0849-0096 14.1 µM -1.14457950057605 0.136728168254745 no 2898 0.126191694010866 980 5286025 SGTC_2674 ligustilide 100 µM -1.15058932743083 0.135434918702223 no 2899 0.12495061286849 975 5319022 A signalling regulator. SGTC_319 1348-1596 45.5 µM -1.15195162167341 0.135142937063269 no 2900 0.124670476885255 966 5380505 SGTC_59 0330-0160 1.33 µM -1.15450451990968 0.134596935293903 no 2901 0.124146693285866 967 4293482 SGTC_247 mechlorethamine 29.705 µM -1.15665421950748 0.134138343545199 no 2902 0.123706830388734 944 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1713 st033146 12.748 µM -1.16085807026022 0.13324464798721 no 2903 0.122849811423955 984 674619 SGTC_109 0132-0036 33.701 µM -1.16419090372243 0.132539039667962 no 2904 0.12217332786193 899 67274 A color developer. SGTC_1325 1431-0015 227 µM -1.16553318861881 0.132255587357963 no 2905 0.12190161705587 954 1103340 SGTC_463 ikarugamyin 104 µM -1.1672509520647 0.131893454637625 no 2906 0.121554519916356 1008 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2977 9011197 71.43 µM -1.1683935573657 0.131652953826075 no 2907 0.121324026254893 935 2704722 SGTC_2753 fluvastatin 17.09 µM -1.17307016285016 0.130671755631364 no 2908 0.120383835239681 981 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2705 st078069 42.8 µM -1.17314881827881 0.130655296288124 no 2909 0.120368066252436 976 1530061 SGTC_1451 4152-0210 104 µM -1.17321731378228 0.130640964166609 no 2910 0.120354335331201 986 659563 SGTC_1854 st056233 32.9 µM -1.17321846324268 0.130640723660737 no 2911 0.120354104914538 989 5393174 SGTC_1123 mangostin 811.285 nM -1.17380420553014 0.130518206445531 no 2912 0.120236729560176 917 5281650 An antioxidant. SGTC_1882 5615643 20 µM -1.17384889578002 0.130508862040149 no 2913 0.120227777511258 924 2253075 SGTC_1217 1183-1422 255 µM -1.17436388859137 0.130401214182502 no 2914 0.120124651515244 955 2849664 SGTC_1728 st035614 33.7865 µM -1.17458470751838 0.130355075687397 no 2915 0.120080452188362 957 15945546 SGTC_758 0868-0029 16 µM -1.17513222645548 0.130240724338205 no 2916 0.119970909720084 945 762687 SGTC_1395 3486-0190 4.35 µM -1.17523294669978 0.130219696104217 no 2917 0.119950766228733 980 6748079 SGTC_1834 st055981 52.8 µM -1.17537152984472 0.130190766745932 no 2918 0.119923054263954 975 471719 YDL150W RPC53 SGTC_1017 4239-0030 168 µM -1.17725770645474 0.129797467787556 no 2919 0.119546331107496 948 1149593 SGTC_2467 5474540 200 µM -1.17739013589162 0.129769885006863 no 2920 0.119519912578732 942 5413519 SGTC_2519 cryptotanshinone 88.04 µM -1.17985846074963 0.129256518069023 no 2921 0.119028256742581 961 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3265 9137266 49.47 µM -1.17989100014625 0.129249759877021 no 2922 0.119021784900131 936 17224265 SGTC_690 glyoxal 20.3 µM -1.18021904442651 0.129181641187441 no 2923 0.118956553226634 965 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_854 0422-0053 192 µM -1.18339307924555 0.128523835275614 no 2924 0.118326699431956 973 3596728 SGTC_1031 k035-0009 16 µM -1.18391499621631 0.128415893056626 no 2925 0.118223356639325 982 5180959 SGTC_3047 9092122 49.47 µM -1.1848376595044 0.128225222987271 no 2926 0.118040819764875 976 17173831 SGTC_760 0568-0725 82.9 µM -1.18611508350641 0.127961565620182 no 2927 0.117788427316398 982 3916171 SGTC_2022 5136654 200 µM -1.18681785971578 0.127816674952404 no 2928 0.117649736288851 984 1713771 SGTC_803 4488-1585 147 µM -1.18715223544495 0.127747777086991 no 2929 0.117583788719969 954 747204 SGTC_761 k216-0224 480 µM -1.18742708422624 0.127691164036357 no 2930 0.117529601008335 1006 1340404 SGTC_813 k007-0158 173 µM -1.18853005073534 0.127464151633659 no 2931 0.117312323885057 976 6523916 SGTC_602 3130-1533 38.1 µM -1.19015682864603 0.127129840939848 no 2932 0.116992378855214 987 720941 SGTC_1138 3761-0006 1.03 µM -1.19021266108043 0.12711837794512 no 2933 0.116981409049477 972 12061087 SGTC_1105 epirubicin 18.1 µM -1.19029409270441 0.127101660453021 no 2934 0.116965410891089 969 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2243 6634756 200 µM -1.1913731796434 0.126880273928613 no 2935 0.116753558524464 973 885676 SGTC_2948 9070189 9.45 µM -1.19209334617227 0.126732673307609 no 2936 0.116612322861142 920 6473636 YDL196W YDL196W SGTC_1223 0764-0573 147 µM -1.19580475541765 0.125973903148288 no 2937 0.115886379877325 965 1609797 SGTC_2923 7992654 58.14 µM -1.19732014240555 0.125665006073261 no 2938 0.115590898213398 951 2985126 SGTC_3154 9100113 49.47 µM -1.20078438141161 0.124960840235194 no 2939 0.11491742596718 973 25237525 SGTC_684 1140-0066 328 µM -1.2012656565386 0.124863231333894 no 2940 0.114824083981013 981 6813534 SGTC_1035 k081-0041 55.2 µM -1.20213404171789 0.124687246245491 no 2941 0.114655799550226 958 731709 SGTC_3041 9091929 49.47 µM -1.20441007706338 0.124226812656635 no 2942 0.114215559536562 967 25236887 SGTC_1357 1503-1303 39.5 µM -1.20485120443884 0.124137711977847 no 2943 0.114130374341904 955 292895 SGTC_190 3970-0790 3.722 µM -1.20521755967956 0.124063748067367 no 2944 0.114059662644952 971 2832352 SGTC_2068 5226020 147 µM -1.20602660215003 0.123900518740345 no 2945 0.113903616683063 991 1810509 SGTC_3169 9102970 49.47 µM -1.21157291471366 0.122785562926454 no 2946 0.11283795390339 1010 17027839 SGTC_2864 9034755 47.6 µM -1.2123799364033 0.122623918457675 no 2947 0.112683488739226 968 4930451 SGTC_1152 3909-8331 15.9 µM -1.21243812783363 0.122612268629686 no 2948 0.112672356651379 962 16001939 SGTC_1487 3970-0795 2.82 µM -1.21574312574115 0.121951887510567 no 2949 0.112041395195391 964 3765103 SGTC_276 colchicine 750 µM -1.21575660441906 0.121949199422108 no 2950 0.112038827145989 977 2833 A microtubule depolymerizer. SGTC_3065 9113888 49.47 µM -1.21716356188618 0.12166883503763 no 2951 0.111770995454448 987 16648368 SGTC_454 lyso-paf C-16 6.67 µM -1.21747516385805 0.121606803435998 no 2952 0.11171174017413 980 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_558 k064-0027 21.3 µM -1.22071340732156 0.120963471514768 no 2953 0.111097274810969 960 5088526 SGTC_2057 5236571 38.335 µM -1.22210828613875 0.120687094444098 no 2954 0.11083334001188 965 54684039 YBR257W POP4 SGTC_1769 st044406 64.4 µM -1.22484821532981 0.120145508054899 no 2955 0.110316207338306 996 670903 SGTC_2917 7979103 53.79 µM -1.22496834091668 0.120121802757372 no 2956 0.110293574563352 982 2980565 SGTC_748 act1.228 77.9 µM -1.22581802503134 0.119954222222062 no 2957 0.110133581268681 980 4421505 YNR035C ARC35 SGTC_2561 acetosyringone 100 µM -1.22975889893388 0.119179130906356 no 2958 0.109393701778478 981 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_390 dec-rvkr-cmk 16.7 µM -1.23288123626531 0.118567544530769 no 2959 0.108810038483393 978 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2300 7976697 71.57 µM -1.23406905161911 0.118335465096014 no 2960 0.108588587317796 961 2236109 SGTC_1413 3910-0535 34.4 µM -1.23727477118478 0.117710724097509 no 2961 0.107992545389718 971 2876951 SGTC_1056 3448-1962 115 µM -1.2382494024022 0.117521248382901 no 2962 0.107811799312678 963 715507 SGTC_2885 9057732 51.95 µM -1.23852250754728 0.117468193419667 no 2963 0.107761190868188 977 6471414 SGTC_1974 st069448 26.9 µM -1.23890944682438 0.117393053427488 no 2964 0.107689517402281 971 6323587 YNR016C ACC1 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.23925164554923 0.117326629998765 no 2965 0.107626159933016 968 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2963 9082507 9 µM -1.24643245164687 0.115938915773667 no 2966 0.106302836791037 997 16459611 SGTC_3100 9120536 49.47 µM -1.24649334296652 0.115927198369135 no 2967 0.106291665834769 968 16421196 SGTC_2081 5214970 32.255 µM -1.24672796120185 0.115882058304685 no 2968 0.106248631336826 991 2063512 SGTC_2223 6903751 107.57 µM -1.24925217839914 0.115397193464496 no 2969 0.10578642644554 976 5598863 SGTC_672 1441-0018 53.7 µM -1.24933303749592 0.115381685494254 no 2970 0.105771644544187 964 251141 SGTC_375 3970-0961 9.27 µM -1.24948893734295 0.115351789635697 no 2971 0.105743148611782 965 2898222 SGTC_9 0092-0002 10.449 µM -1.25304131855624 0.114672065011617 no 2972 0.105095335027797 979 759368 SGTC_232 clozapine 119 µM -1.25496715313739 0.114304762994296 no 2973 0.10474534210107 984 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_734 2023-0417 80 µM -1.25606078706615 0.114096554566109 no 2974 0.104546965918381 993 3935732 SGTC_702 1488-0190 94 µM -1.25626115883763 0.114058436649396 no 2975 0.104510649651251 974 949357 SGTC_2743 auranofin 4.32 µM -1.25763476314991 0.113797371957197 no 2976 0.104261937583478 963 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.25965860028166 0.113413501646594 no 2977 0.103896273030776 1008 390807 SGTC_1177 0983-0204 23.6 µM -1.2597777653679 0.113390927891619 no 2978 0.103874771452769 966 766818 SGTC_2101 5377231 179.231 µM -1.26121551198308 0.113118824320314 no 2979 0.103615605669752 998 2844213 SGTC_912 3474-0017 2.18 µM -1.26392853282128 0.112606636013309 no 2980 0.103127839765374 997 3360550 SGTC_1844 rapamycin 4 nM -1.26542014103044 0.112325743578033 no 2981 0.102860379481181 934 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1503 4585-0012 61.3 µM -1.2680719934264 0.111827596591925 no 2982 0.10238612097882 1001 2922052 SGTC_867 0518-0118 155 µM -1.26947317468249 0.111565025425831 no 2983 0.102136176078251 962 6848158 SGTC_3215 9129942 49.47 µM -1.27147260151778 0.111191111708284 no 2984 0.101780284287705 996 17682944 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.27360566939932 0.110793195892571 no 2985 0.101401601000853 985 688662 SGTC_891 0929-0073 133 µM -1.27436899809144 0.110651047976588 no 2986 0.101266337011412 1004 5603632 SGTC_2017 5132927 60.65 µM -1.28109764192694 0.109403684155618 no 2987 0.100079686010475 1000 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2505 galangin 7.89 µM -1.2841254431153 0.108845694015645 no 2988 0.0995490334563653 1000 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2128 5255449 168.493 µM -1.28764508053954 0.108199639143021 no 2989 0.0989347695752509 968 736008 SGTC_3044 9093193 49.47 µM -1.28878370303944 0.107991228844343 no 2990 0.0987366466207768 979 25236277 SGTC_886 0866-0150 153 µM -1.29272906148742 0.10727131777696 no 2991 0.0980523914052835 994 271463 SGTC_1950 st077106 7.18 µM -1.2939933339435 0.107041359185461 no 2992 0.0978338616860907 972 13831864 SGTC_1947 st076332 61.6 µM -1.29494280908662 0.106868893029465 no 2993 0.0976699796217796 989 24208416 SGTC_2441 5730946 39.09 µM -1.29895330803231 0.1061426231715 no 2994 0.0969799767714336 970 1774275 SGTC_2106 5357045 167.29 µM -1.29986115817179 0.105978714724715 no 2995 0.0968242798615435 991 668842 SGTC_2242 6630449 61.2675 µM -1.29994592817223 0.105963419206662 no 2996 0.0968097511242837 993 691249 YDR170C SEC7 SGTC_1836 st055642 81 µM -1.3035302721933 0.10531813536094 no 2997 0.096196894169886 981 8571 SGTC_3262 9137218 49.47 µM -1.30657468366923 0.10477229145529 no 2998 0.0956785996565911 964 17650664 SGTC_1678 st019265 80.2 µM -1.30669056169166 0.104751555799745 no 2999 0.0956589127225518 987 5367020 SGTC_1303 1160-0052 261 µM -1.30752013091504 0.104603196307311 no 3000 0.0955180612636622 975 3562476 SGTC_2033 5192550 145 µM -1.30823037606854 0.104476297625362 no 3001 0.0953975910130645 972 182073 SGTC_2249 haloperidol 116.36 µM -1.30837000857481 0.104451362771776 no 3002 0.0953739200103023 972 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_933 2914-0560 114 µM -1.30864732086356 0.104401854557985 no 3003 0.0953269218586857 987 463887 SGTC_2351 9026858 72.31 µM -1.31109965401228 0.103964782527991 no 3004 0.094912048827035 1022 1409300 SGTC_564 3555-0129 330 µM -1.31729756685102 0.102866065056576 no 3005 0.0938694502450863 965 563260 SGTC_987 1497-1013 404 µM -1.3232359450421 0.10182129325526 no 3006 0.0928784629157494 1004 1676435 SGTC_671 0560-0003 407 µM -1.32400160209549 0.1016871511415 no 3007 0.0927512563184912 995 3238678 SGTC_1461 k072-0203 53.8 µM -1.3242904177422 0.101636584454505 no 3008 0.0927033058426237 980 5418714 SGTC_1211 1056-0033 32.3 µM -1.32494949694708 0.101521259513465 no 3009 0.0925939512023222 973 6741922 SGTC_3285 9112818 20.8695 µM -1.32557880101311 0.101411233562114 no 3010 0.0924896259444078 988 17017947 YPR165W RHO1 SGTC_655 k060-0012 42 µM -1.32559831756363 0.101407822726379 no 3011 0.0924863919054647 1013 5994525 SGTC_464 bw-b 70c 158 µM -1.32659714472204 0.101233372939696 no 3012 0.092320990438601 1003 5353454 SGTC_1222 0366-0074 1.18 µM -1.32728824669531 0.101112796842844 no 3013 0.0922066751398215 1004 286520 SGTC_311 1315-0136 58 µM -1.32795806472461 0.100996034057 no 3014 0.0920959804425575 1002 6759207 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.32839317216244 0.100920238739149 no 3015 0.0920241269500095 1006 115019 SGTC_603 3794-0023 45.9 µM -1.32950447178499 0.100726839603224 no 3016 0.0918407957302248 1011 3802260 SGTC_320 4092-0846 5.34 µM -1.33327754491408 0.100072229760297 no 3017 0.0912203699289841 993 1359356 SGTC_2402 5553605 200 µM -1.33351715948023 0.100030762938927 no 3018 0.0911810740804813 1017 6758546 SGTC_2546 rhodinyl acetate 100 µM -1.33427009387388 0.099900544520416 no 3019 0.0910576774902886 978 6708682 SGTC_2014 4013930 200 µM -1.33454465574655 0.099853090441066 no 3020 0.0910127110434798 1003 64556 SGTC_2504 purpurogallin 52.29 µM -1.33834359233104 0.0991981879495306 no 3021 0.0903922288224919 996 5281571 An antioxidant. SGTC_2521 angolensin 13.4 µM -1.33965832839548 0.09897227248895 no 3022 0.0901782256261712 992 821428 A flavenoid. SGTC_312 4092-0653 6.84 µM -1.3400549903618 0.0989041867124148 no 3023 0.0901137338324929 972 1148278 SGTC_1925 st057770 10.1 µM -1.34452979296717 0.09813847362062 no 3024 0.0893885644761295 993 5989122 SGTC_94 0334-0113 514.748 µM -1.34468752853559 0.0981115619099469 no 3025 0.0893630818916888 991 6795178 SGTC_3248 9135562 49.47 µM -1.34571535834558 0.0979363333568798 no 3026 0.0891971656789258 990 17650701 SGTC_2714 st079313 56.9 µM -1.35146147400782 0.0969609364260394 no 3027 0.0882738265350603 1008 2939799 SGTC_2492 derrusnin 100 µM -1.35309245127948 0.0966853835773503 no 3028 0.0880130484663623 1002 1715307 Part of coumarin class of compounds. SGTC_3086 9117350 49.47 µM -1.35764287117065 0.0959196339012933 no 3029 0.0872885162470604 981 2679265 SGTC_1798 st045719 60.953 µM -1.35910011861548 0.0956753521160118 no 3030 0.0870574326340725 970 3980186 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.3628790118867 0.0950440205158923 no 3031 0.0864603221654157 1016 94937 An inhibitor of serotonin biosynthesis. SGTC_1067 clotrimazole 1.36 µM -1.36351803450879 0.0949375644014586 no 3032 0.0863596523275027 983 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2054 5233173 129 µM -1.36761550682397 0.094257044737742 no 3033 0.0857162299956986 875 6889 SGTC_1721 st082152 9.2685 µM -1.36763876024991 0.0942531930380237 no 3034 0.0857125888005983 989 5296051 SGTC_2570 licareol 100 µM -1.37946908395554 0.0923086385980496 no 3035 0.0838750859755909 1001 443158 SGTC_2041 5107442 45.335 µM -1.38004176134686 0.0922152665251842 no 3036 0.0837868935124673 1004 793005 SGTC_1414 3917-0015 5.4 µM -1.38227921281935 0.0918511318160864 no 3037 0.0834429930465595 1008 6618702 SGTC_1272 0839-0021 27 µM -1.38316722520861 0.091706907575976 no 3038 0.0833067983517716 1019 5027250 SGTC_2878 9043973 25.97 µM -1.38342184961174 0.0916655843780664 no 3039 0.083267777385005 1023 6465167 SGTC_1444 4112-3581 28 µM -1.38371732389131 0.0916176489166988 no 3040 0.0832225134371694 998 2877249 SGTC_217 ketoconazole 989 nM -1.38783336173447 0.090951825219558 no 3041 0.0825938966955516 942 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2489 cantharidin 73.42 µM -1.3914627755713 0.0903677034374504 no 3042 0.0820425700055556 993 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_959 1222-0044 107 µM -1.3955177567824 0.0897183904844273 no 3043 0.0814298819749146 992 6083612 SGTC_2958 9077254 16.72 µM -1.39660285260499 0.0895452267742448 no 3044 0.0812665160040638 1010 16457351 SGTC_2000 st075254 36.4 µM -1.40093881593148 0.0888557578291221 no 3045 0.0806161850600912 995 17234175 SGTC_2767 sibutramine 71.45 µM -1.40118044766978 0.088817452148486 no 3046 0.0805800598035538 1011 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1404 3909-7820 48.3 µM -1.40367081390386 0.0884233726199502 no 3047 0.0802084486756963 960 23741373 SGTC_666 0272-0154 136 µM -1.4044759425235 0.0882962468807995 no 3048 0.0800885853060357 1034 6870312 SGTC_246 cycloheximide 667 µM -1.40697475956693 0.0879025637315822 no 3049 0.0797174366933438 1013 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3224 9130643 49.47 µM -1.40731756276932 0.0878486581108585 no 3050 0.0796666218836903 1004 17644395 SGTC_547 1120-0019 610 nM -1.40774379959902 0.0877816669890778 no 3051 0.079603473623686 959 3676939 SGTC_2851 9015922 71.43 µM -1.40814270308619 0.0877190063420186 no 3052 0.0795444091941188 995 2996893 SGTC_2079 5212404 121 µM -1.41090233786938 0.0872864304242775 no 3053 0.079136706369873 1006 758462 SGTC_2487 5918373 44.05 µM -1.41192191288448 0.0871270144182485 no 3054 0.0789864774018824 1021 2876279 SGTC_941 3237-0776 460 µM -1.41568403075801 0.0865406682987652 no 3055 0.0784340179854226 1017 760008 SGTC_1684 st024538 14.6195 µM -1.41692824043648 0.0863474021378537 no 3056 0.0782519544343691 1019 6732859 SGTC_3160 9100216 49.47 µM -1.41725420000773 0.0862968234277457 no 3057 0.0782043102264918 1010 17191039 SGTC_85 0868-0259 160.055 µM -1.41977866740054 0.0859058552697726 no 3058 0.0778360636770506 991 83173 SGTC_69 0096-0274 206.684 µM -1.42567832859599 0.0849973367044073 no 3059 0.0769806074151 1023 6741392 SGTC_1171 0368-0077 21.4 µM -1.42643351888065 0.0848815630445166 no 3060 0.0768716220625743 1019 3239779 SGTC_766 1391-0721 126 µM -1.42712785496261 0.0847752229298927 no 3061 0.0767715224281162 1024 1020919 YIL115C NUP159 SGTC_2806 7952793 58.44 µM -1.42747739922011 0.084721726764892 no 3062 0.0767211675619144 997 2972490 SGTC_2217 6934799 96.0675 µM -1.43129517462672 0.0841390808275462 no 3063 0.0761728181485645 1013 675606 SGTC_1310 1188-0297 994 nM -1.43254618090868 0.0839488155569497 no 3064 0.0759937857738913 978 1588352 SGTC_2166 5933061 31.504 µM -1.43595778955721 0.0834315868494435 no 3065 0.0755071763464144 1018 2877375 SGTC_816 0325-0417 81.3 µM -1.44337086750218 0.0823159636793729 no 3066 0.0744580130733801 999 68101 SGTC_841 0251-0215 91.2 µM -1.44586384729411 0.081943320702601 no 3067 0.0741076969098231 1027 3888614 SGTC_2141 5621638 7.665 µM -1.44956928830793 0.0813917936324652 no 3068 0.0735893327398332 1021 2856238 SGTC_1877 wortmannin 25 µM -1.45176753524332 0.0810659269541734 no 3069 0.0732831268424782 1021 312145 A covalent inhibitor of PI 3-kinase. SGTC_397 arbidol 50 µM -1.45593457464072 0.08045091153782 no 3070 0.0727053533481332 1013 131410 A RNA synthesis inhibitor. SGTC_645 0845-0943 5.41 µM -1.46190965340246 0.0795752067569554 no 3071 0.071882984646485 1012 1885106 SGTC_3281 9140613 49.47 µM -1.46428943838359 0.0792284419292178 no 3072 0.0715574408467844 986 16013766 SGTC_2113 5491891 107.031 µM -1.46436941747207 0.0792168078649638 no 3073 0.0715465197507267 1005 789979 SGTC_2420 aureobasidin a 50 nM -1.46472871650703 0.0791645588094044 no 3074 0.0714974734631638 1011 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1052 3253-3998 198 µM -1.46696945325114 0.0788393008301819 no 3075 0.0711921826122738 1013 5450317 SGTC_516 3992-2719 87.3 µM -1.46780276150608 0.0787185991601262 no 3076 0.0710789035747175 1032 5350887 YDR037W KRS1 SGTC_3136 9095672 49.47 µM -1.46899476830896 0.0785461848007354 no 3077 0.0709171041217695 994 17217380 SGTC_1911 st060208 74.3 µM -1.47236819244282 0.0780597970526192 no 3078 0.0704607388238201 1023 688783 SGTC_1258 0671-0043 57.1 µM -1.47309845724339 0.0779548073569128 no 3079 0.0703622446912492 1028 4298767 SGTC_3105 9121040 49.47 µM -1.47711487686811 0.0773792837107054 no 3080 0.0698224231737638 981 41448907 SGTC_3337 9144342 33.5465 µM -1.4793124533115 0.0770657560362343 no 3081 0.0695284130207166 1012 17682949 SGTC_19 0279-0214 38.434 µM -1.48000859645068 0.0769666390914594 no 3082 0.0694354762706195 1031 3566274 YBR002C RER2 SGTC_2595 hexamethylquercetagetin 100 µM -1.4834370545178 0.0764799080266352 no 3083 0.0689791643178823 1032 386331 SGTC_609 0986-0026 86.3 µM -1.48368258744333 0.0764451402853275 no 3084 0.0689465739215791 1000 2848610 SGTC_1565 sinapyl alcohol 95.1 µM -1.48432090145533 0.0763548105604916 no 3085 0.0688619039304799 995 5280507 A phenol propionate derived from cinnamic acid. SGTC_3318 9139014 38.6185 µM -1.48644354065586 0.0760550135841882 no 3086 0.0685809201291172 1013 16643984 SGTC_751 0833-0568 350 µM -1.48731707773357 0.0759318976973353 no 3087 0.0684655430683278 1035 6954252 SGTC_1835 st008666 49.2 µM -1.4905878188726 0.0754722686726247 no 3088 0.0680348721797488 1011 690455 SGTC_499 genistein 192 µM -1.49212147019705 0.0752574800557523 no 3089 0.0678336521656971 1043 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_412 gemfibrozil 100 µM -1.49232704791202 0.0752287242516068 no 3090 0.0678067146759627 1013 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_856 0433-0016 11.3 µM -1.49545282507288 0.0747925280857333 no 3091 0.0673981514738858 1021 3911780 SGTC_1332 1480-0653 17.5 µM -1.50166169890737 0.0739318187194924 no 3092 0.0665922501199924 1026 5749438 SGTC_2218 6965428 192.983 µM -1.50329121357276 0.0737071848470326 no 3093 0.0663819824468004 1007 675684 SGTC_449 xestospongin c 11.1929 µM -1.50506087750605 0.0734638223268414 no 3094 0.0661542130310246 1030 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_166 k072-0058 166.424 µM -1.51266838855695 0.0724246385037811 no 3095 0.0651819565496512 1006 5846229 SGTC_2469 5655019 90.81 µM -1.51680230149933 0.0718646897160022 no 3096 0.0646583029026146 1028 2788239 SGTC_2283 7944793 200 µM -1.51714385791352 0.0718185739510616 no 3097 0.06461518360353 995 2970533 SGTC_3009 9080819 71.4286 µM -1.51948508022946 0.0715030809712816 no 3098 0.0643202203510782 1032 17027216 SGTC_2308 7584454 197.62 µM -1.52257064561421 0.0710889093682555 no 3099 0.063933079223815 1014 893577 SGTC_2774 tamoxifen 10.92 µM -1.52569146671711 0.0706718819279165 no 3100 0.0635433603332985 1014 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2568 diosmetin 100 µM -1.53023613378297 0.0700679552123638 no 3101 0.0629791451671297 1025 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3331 9141060 1.957 µM -1.53517060198828 0.0694167331424011 no 3102 0.0623709637536632 1019 4906567 YPR165W RHO1 SGTC_195 4234-0266 16.654 µM -1.5365405031719 0.0692367709103407 no 3103 0.0622029359739239 1033 2303354 SGTC_2077 5212015 200 µM -1.53781308624211 0.0690699154870455 no 3104 0.0620471614913071 1015 780900 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.53789749511745 0.0690588591397143 no 3105 0.0620368399347918 983 279621 SGTC_2034 5197015 53.07 µM -1.53852342992104 0.0689769132474073 no 3106 0.06196034213392 1032 780676 SGTC_2137 5261020 140 µM -1.54011377970084 0.0687690455786437 no 3107 0.0617663107369777 1023 763655 SGTC_2479 5617353 43.85 µM -1.54068259596605 0.0686948154775347 no 3108 0.0616970273140287 1019 2731746 SGTC_2763 lisinopril 49.32 µM -1.5455252498189 0.0680653527815311 no 3109 0.0611096331261213 1006 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_176 1486-1328 72.834 µM -1.54651562418145 0.0679371711165401 no 3110 0.0609900448341588 1012 22310231 SGTC_2620 irigenin 100 µM -1.54787810445016 0.0677611334299128 no 3111 0.0608258235928809 1013 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_794 k038-0031 316 µM -1.54852388071632 0.067677819826684 no 3112 0.0607481083479228 1003 6624242 SGTC_2803 7707263 71.43 µM -1.54887177740041 0.0676329694058132 no 3113 0.0607062732963762 1014 2199229 SGTC_286 k060-0067 22.9 µM -1.54922072599285 0.0675880064455974 no 3114 0.0606643343903576 1038 5985051 SGTC_2356 9061756 188.97 µM -1.55221143718083 0.0672035920173791 no 3115 0.0603058201787645 1027 20104043 SGTC_471 1-acyl-paf 4 µM -1.55226358111303 0.0671969046638061 no 3116 0.0602995841183044 1038 16759367 SGTC_2074 5212007 75.395 µM -1.55355198031617 0.06703183344431 no 3117 0.0601456605644395 1024 758611 SGTC_2797 7859098 81.82 µM -1.55609061103092 0.0667074990712403 no 3118 0.0598432736585751 1007 972681 SGTC_594 1487-1584 10.8 µM -1.55996073739445 0.0662153919722666 no 3119 0.0593845799001374 1041 5013332 SGTC_259 usnic acid 108.925 µM -1.5619214139421 0.0659671569954627 no 3120 0.059153251569509 1052 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1415 3966-0071 78.1 µM -1.56258942946221 0.0658827465833353 no 3121 0.059074598087618 1026 2893185 SGTC_2205 7238770 200 µM -1.56297092471782 0.0658345784249504 no 3122 0.0590297168898503 1028 279867 SGTC_2453 5731132 22.18 µM -1.56716461669456 0.0653068742132926 no 3123 0.058538109342374 1038 1362040 SGTC_391 gliotoxin 8.33 µM -1.57450375888786 0.0643912725306366 no 3124 0.0576855166059769 1025 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1418 3966-3099 2.4 µM -1.58069821579642 0.0636262662837303 no 3125 0.0569735282668668 1021 740335 SGTC_834 0312-0008 75.7 µM -1.58220108948404 0.0634417338551717 no 3126 0.0568018358757067 1045 6385573 YIL048W NEO1 SGTC_192 3455-0609 60.9 µM -1.58540910451974 0.0630492271024146 no 3127 0.0564367069629386 1028 3769639 SGTC_2219 9098279 200 µM -1.58712918477971 0.0628395523617117 no 3128 0.0562416945942793 1035 902349 SGTC_1309 pyrazolanthrone 13.4 µM -1.59625582579961 0.0617361073398684 no 3129 0.0552158441253451 1032 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1117 retinoic acid 1.10837 µM -1.59721441617303 0.0616210935275327 no 3130 0.0551089601560283 1053 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1629 st005085 44.9 µM -1.60198382275678 0.0610513348576585 no 3131 0.0545795934261421 1010 24207091 SGTC_1275 0867-0008 21.1 µM -1.60610131022896 0.0605627744846176 no 3132 0.0541258260316372 1045 3422836 SGTC_1007 4101-0031 70 µM -1.60810172780294 0.0603265215815044 no 3133 0.0539064504360315 1048 1146276 SGTC_763 3453-1109 128 µM -1.60911309929018 0.060207351634481 no 3134 0.0537958067252679 1037 1560353 SGTC_2607 solasodine 47.35 µM -1.60980445083689 0.0601259957491228 no 3135 0.0537202766315441 1031 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_361 000s-0510 1.45 µM -1.61540877638916 0.0594696709592431 no 3136 0.0531111004545776 1012 660 SGTC_445 e6 berbamine 66 µM -1.61621029019179 0.0593762661205096 no 3137 0.0530244273625071 1022 6610268 A calcium/calmodulin antagonist. SGTC_3190 9110366 49.47 µM -1.62609795006257 0.0582334405740533 no 3138 0.0519644100289119 1039 17123768 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.62811477637046 0.0580024695352101 no 3139 0.0517502754678202 1025 688667 SGTC_2695 st077686 51.995 µM -1.63135594851622 0.0576327928910589 no 3140 0.0514076171363275 1027 2876092 SGTC_1397 3532-0190 20.1 µM -1.63307560913252 0.0574374082133628 no 3141 0.0512265478542821 1046 5322280 SGTC_64 000l-0018 272.079 µM -1.63718554896302 0.0569725553562761 no 3142 0.050795852800838 1011 6811119 SGTC_575 k072-0246 11.9 µM -1.63806137970432 0.0568738788524907 no 3143 0.0507044451602835 1052 6796779 SGTC_2035 5154463 94.595 µM -1.64018073940913 0.056635655578286 no 3144 0.0504837963917655 1037 2769623 SGTC_701 4424-0219 185 µM -1.64258943587232 0.0563658650731899 no 3145 0.0502339539798205 1040 2911779 SGTC_1789 tunicamycin 25 nM -1.64308730012516 0.0563102274013645 no 3146 0.0501824360454184 1013 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3306 9127676 59.7925 µM -1.64312324926141 0.056306211664996 no 3147 0.0501787177362047 1025 41905287 SGTC_739 1486-1183 203 µM -1.64549379259259 0.0560419055252831 no 3148 0.0499340108598443 1040 4346692 SGTC_2734 clemastine 41.6 µM -1.6490586944388 0.0556462765159046 no 3149 0.0495678053556259 1071 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2586 curcumin 80 µM -1.65409059876617 0.0550915966470227 no 3150 0.0490545529883446 1049 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2053 5265679 138 µM -1.65487577205765 0.0550054403022224 no 3151 0.0489748498746341 1011 764595 SGTC_2533 agelasine 13.65 µM -1.65713989640808 0.0547575960682373 no 3152 0.0487455973259987 1018 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2622 2-methoxyxanthone 59.94 µM -1.6573314766172 0.0547366651583734 no 3153 0.0487262384121654 1048 71034 A hepatoprotective. SGTC_2048 5246248 200 µM -1.66052367404423 0.0543888346333358 no 3154 0.0484045746870767 1028 677046 SGTC_1606 st000094 49.2 µM -1.66211045235299 0.0542165867340511 no 3155 0.0482453151025675 1032 1242210 SGTC_3069 9117009 49.47 µM -1.66335409831382 0.0540818884916882 no 3156 0.0481207878103855 1040 41904981 SGTC_1299 1079-1439 3.74 µM -1.66389528781265 0.054023355487221 no 3157 0.0480666784375365 1040 323161 SGTC_3299 9121982 43.1275 µM -1.66501185197379 0.053902750606096 no 3158 0.0479551956450474 1034 17594604 YPL160W CDC60 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.66618082409642 0.0537767134371886 no 3159 0.0478387020723888 1050 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1351 1496-0003 46.5 µM -1.66861930776644 0.0535145503166871 no 3160 0.047596424976289 1051 3891978 SGTC_99 0109-0120 622.8 µM -1.66959412358132 0.0534100309105382 no 3161 0.0474998469283204 1035 759414 SGTC_2115 tiliquinol 12.7705 µM -1.66968054235728 0.0534007729317043 no 3162 0.0474912927314705 1041 71208 A bioactive hydroxyquinoline. SGTC_902 1120-0002 2.07 µM -1.6745295273448 0.052883339313458 no 3163 0.0470132881660297 990 3280475 SGTC_262 fenpropimorph 62.5 µM -1.67468694980303 0.052866607703227 no 3164 0.0469978346260717 1063 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2844 9010103 25.97 µM -1.68863436899981 0.051400802105237 no 3165 0.0456447600268663 1031 2480525 SGTC_3166 9102297 49.47 µM -1.69252074187478 0.0509981742963884 no 3166 0.0452733643609021 1035 25237072 SGTC_2678 equilin 100 µM -1.70244713566212 0.0499811901766473 no 3167 0.0443357902019316 1020 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2789 5281112 71.43 µM -1.704961661203 0.0497261549038671 no 3168 0.0441007874927714 1035 765948 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.70546834639656 0.0496748903547714 no 3169 0.0440535554623362 1018 88881 An O-methylated flavonoid and antioxidant. SGTC_258 haloperidol 50.781 µM -1.70839684609315 0.0493794211899405 no 3170 0.0437813660402995 1048 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3325 9138760 55.175 µM -1.71166569714165 0.0490512714041155 no 3171 0.0434791468078187 1022 43844959 SGTC_2583 asiatic acid 100 µM -1.71700233041307 0.0485192891690526 no 3172 0.0429893730959872 1043 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1619 st003326 88.7 µM -1.73851985838568 0.0464209544312672 no 3173 0.041059627033128 996 2849032 SGTC_2816 7982706 58.44 µM -1.74112941435822 0.0461715066402625 no 3174 0.0408304482251695 1037 2981853 SGTC_2684 capsaicin 100 µM -1.74135761165818 0.0461497445143413 no 3175 0.0408104567170197 1041 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_4 0960-0234 25.671 µM -1.74350636731054 0.0459452313406448 no 3176 0.0406226015220097 1028 6821112 SGTC_1372 2752-0194 270 µM -1.74428337176533 0.0458714575149134 no 3177 0.0405548448493865 1037 823334 SGTC_1140 3229-1848 2.98 µM -1.74505381544876 0.045798400628135 no 3178 0.0404877509026239 1039 2849525 SGTC_2709 st078560 56 µM -1.74740363674817 0.0455761575384152 no 3179 0.0402836735466742 1056 17250903 SGTC_3027 9089541 49.47 µM -1.74790979104418 0.0455283998002089 no 3180 0.0402398245845602 1053 9943819 SGTC_2928 9011484 9.79 µM -1.74802510784632 0.0455175248161291 no 3181 0.0402298399286277 1006 2994751 SGTC_3029 9088683 49.47 µM -1.7503753688672 0.045296337531565 no 3182 0.0400267816798656 1034 25236615 SGTC_1851 st056236 18.9 µM -1.75140288347322 0.0451999083146254 no 3183 0.0399382683329742 1032 5393171 SGTC_470 aa-861 153 µM -1.75588502619475 0.044781202478728 no 3184 0.0395540211155222 1035 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_465 cgp-37157 41 µM -1.75960825508308 0.044435771350896 no 3185 0.0392371254467927 1052 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_727 3032-0951 202 µM -1.76129308997972 0.0442801640992495 no 3186 0.0390944045027205 1058 3652836 SGTC_2853 9015042 58.44 µM -1.76658958988913 0.0437938508767158 no 3187 0.0386484928267719 1034 6457456 SGTC_509 pifithrin 175 µM -1.76716492713093 0.0437412850962301 no 3188 0.0386003057798405 1068 4817 A p53 inhibitor. SGTC_646 4092-0839 27.3 µM -1.76794075316459 0.0436704822423939 no 3189 0.0385354044372646 1044 877796 SGTC_2720 fluspirilene 36.88 µM -1.76802340138119 0.0436629451164822 no 3190 0.0385284957862194 1046 3396 An atypical antipsychotic. SGTC_2549 cedrol 20.94 µM -1.77052243169707 0.043435540681262 no 3191 0.0383200754773535 1036 6708665 A sedative which affects the nervous system. SGTC_2992 9074591 71.4286 µM -1.77376364374164 0.043142025130688 no 3192 0.0380511270725931 1045 17741321 SGTC_2722 naftopidil 47.16 µM -1.77486619143976 0.0430425472827879 no 3193 0.0379599919077732 1045 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2027 5150920 200 µM -1.78064273606381 0.0425243809214835 no 3194 0.0374854167634346 1020 786715 SGTC_1022 4477-0945 21.3 µM -1.78248050400778 0.0423605915972202 no 3195 0.037335453866454 1046 4648966 SGTC_1972 st070201 17.4 µM -1.78670132611904 0.0419863465160999 no 3196 0.0369928873242475 1050 2829099 SGTC_1985 st071382 65.5 µM -1.79556426394431 0.0412092120690725 no 3197 0.0362819218132256 1062 6123237 SGTC_2811 7967822 32.47 µM -1.79646114501658 0.0411312243203727 no 3198 0.0362106034392692 1034 2232244 SGTC_369 0957-0393 4.5 µM -1.79896318030642 0.0409142938079037 no 3199 0.0360122526086451 1051 6997992 SGTC_184 1494-0393 24.714 µM -1.80026413231892 0.0408018664392137 no 3200 0.0359094707812165 1050 3090647 SGTC_1571 st070080 73.4 µM -1.80037342864194 0.0407924325520226 no 3201 0.0359008467695609 1046 4315245 SGTC_1020 4335-0961 93.3 µM -1.80280999145785 0.0405825803114059 no 3202 0.0357090302437128 1051 669075 SGTC_1 0258-0098 57.368 µM -1.80532478238252 0.0403669103806479 no 3203 0.0355119369004134 1013 6790032 YDR047W HEM12 SGTC_2412 st077135 33.4 µM -1.80778664509958 0.0401566820759193 no 3204 0.035319856543615 1055 13258915 SGTC_1739 st037196 92.5 µM -1.81280913736891 0.0397305495873377 no 3205 0.034930632085555 1042 612214 SGTC_1231 0242-0792 125 µM -1.81685217981331 0.0393901957557038 no 3206 0.0346198752779708 1050 3707635 SGTC_1948 st076329 66.6 µM -1.82115586654639 0.0390305106071825 no 3207 0.0342915835116279 1046 24208413 SGTC_2 0422-0095 29 µM -1.822151429957 0.0389476873312596 no 3208 0.0342160059546172 1036 6790840 SGTC_2742 clothiapine 36.27 µM -1.82308375024749 0.038870255221354 no 3209 0.0341453536643294 1067 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_159 3970-0959 50 µM -1.82325617381167 0.0388559486529413 no 3210 0.0341323003620952 1037 6615653 SGTC_1459 k035-0031 35.7 µM -1.83114283976007 0.0382061359077939 no 3211 0.0335396128691568 1022 3877128 YMR208W ERG12 SGTC_3242 9133940 49.47 µM -1.83126560240044 0.0381960915018379 no 3212 0.033530454576624 1056 17248444 SGTC_2431 5490079 200 µM -1.83715649019855 0.0377166260226903 no 3213 0.0330933983729731 1063 5722345 SGTC_2877 9040724 71.43 µM -1.84510630405298 0.0370773825613218 no 3214 0.0325110381815771 1058 6463895 SGTC_801 0866-0028 10.1 µM -1.84953744807208 0.0367249356605111 no 3215 0.0321901228072476 1061 6849771 SGTC_3327 9140648 26.9345 µM -1.85766309283174 0.0360857545317076 no 3216 0.0316084363637181 1039 8029710 SGTC_2525 harmine 47.85 µM -1.85918361075757 0.035967165068415 no 3217 0.0315005585402689 1050 5280953 A monoamine oxidase inhibitor SGTC_2398 5228213 48.84 µM -1.86863624611701 0.0352370695741873 no 3218 0.0308367196910771 1057 80771 YMR134W ERG29 SGTC_140 0062-0056 502.533 µM -1.86961708779514 0.0351620132587042 no 3219 0.0307685053122079 1055 3758964 SGTC_3263 9137018 49.47 µM -1.86970628657975 0.0351551940691464 no 3220 0.0307623080261146 1042 43844957 SGTC_563 tetrahydrosecaminediol 614 µM -1.8738114625169 0.0348425281968319 no 3221 0.0304782079767328 1066 334274 A psychoactive constituent of the cannabis plant. SGTC_1167 k781-0610 148 µM -1.87575839961484 0.0346950421448042 no 3222 0.030344231358652 1041 4525169 SGTC_1205 4161-2785 76 µM -1.87639237754863 0.0346471273020186 no 3223 0.0303007102434935 1050 3498106 SGTC_353 1988-1175 58.3 µM -1.88757936452906 0.0338105396927261 no 3224 0.0295412212600212 1029 2788357 SGTC_1830 st055982 50.3 µM -1.89666680991511 0.0331432569919975 no 3225 0.0289359634084681 1058 455313 An antimicrobial agent. SGTC_3129 9127257 49.47 µM -1.89933830142748 0.0329491682317542 no 3226 0.0287600050083215 1056 837894 SGTC_194 1486-1323 56.904 µM -1.90077632549801 0.0328450815718559 no 3227 0.0286656581407182 1059 5178754 SGTC_1321 1326-2144 215 µM -1.90434191667394 0.0325881667619013 no 3228 0.0284328342353735 1056 3513030 SGTC_968 1309-0633 340 µM -1.90516194485271 0.0325293155442217 no 3229 0.0283795116338133 1054 3761976 SGTC_2874 9043904 71.43 µM -1.90543841863211 0.0325094935364044 no 3230 0.0283615526034992 1051 4463428 SGTC_901 1112-0062 60.1 µM -1.90754524229469 0.0323587701738578 no 3231 0.0282250091201357 1056 1908457 SGTC_1770 st043884 66.3 µM -1.9100255732882 0.0321820653861347 no 3232 0.0280649603514162 1063 670149 SGTC_911 3456-4043 236 µM -1.91241625923939 0.0320125017450426 no 3233 0.0279114120759468 1054 914281 SGTC_1203 3992-3522 103 µM -1.91699862347462 0.0316895516226723 no 3234 0.0276190532631319 1061 5322312 SGTC_359 0081-0058 15.9 µM -1.91988467979928 0.0314875369209237 no 3235 0.0274362337375285 1050 3494159 SGTC_2170 morpholine 200 µM -1.92650024486279 0.0310284834742978 no 3236 0.0270209706526456 1067 121171 Reacts with secondary amines. SGTC_1547 harmine 94.2 µM -1.93255322362188 0.0306133326372328 no 3237 0.0266456297444591 1037 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_731 3966-0296 387 µM -1.95821211948055 0.0289042457932162 no 3238 0.0251025638036593 1064 660956 SGTC_1036 k216-0215 33.5 µM -1.95947818965617 0.0288220110078088 no 3239 0.0250284058358096 963 622330 SGTC_2994 9053520 71.4286 µM -1.9721772546436 0.0280078808205775 no 3240 0.0242946876261858 1057 4647384 SGTC_1545 lovastatin 49.4 µM -1.97281918711177 0.0279672406288025 no 3241 0.0242580831691794 1073 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1931 st074438 57.1 µM -1.9742174455974 0.0278788880761211 no 3242 0.0241785115701906 1071 2787313 SGTC_1164 k060-0068 93.7 µM -1.98657976846303 0.0271078131569184 no 3243 0.0234844925274646 1070 5963676 SGTC_3093 9117344 49.47 µM -1.99190654985702 0.0267810951300045 no 3244 0.0231906560955565 1057 24824913 SGTC_2701 st077767 14.721 µM -1.99616924863221 0.0265220170320093 no 3245 0.0229577517343781 1057 5721188 SGTC_3204 9114183 49.47 µM -1.99932042846379 0.0263318438306072 no 3246 0.0227868476146789 1043 17027248 SGTC_2959 9079155 11 µM -2.00229695934044 0.026153258793773 no 3247 0.0226264014238582 1064 16189457 SGTC_1215 3852-0577 11.2 µM -2.00290684148763 0.0261167925593402 no 3248 0.0225936443129705 1059 2884876 SGTC_419 nsc-638432 893 µM -2.02926314601429 0.0245810348407109 no 3249 0.021215747456591 1066 368090 SGTC_15 0266-0086 27.098 µM -2.02945415065128 0.0245701879281719 no 3250 0.021206027210706 1082 1712902 YIL048W NEO1 SGTC_2198 6589944 200 µM -2.03134077261175 0.0244632646653416 no 3251 0.0211102190189586 1049 5290268 SGTC_1641 st009299 47.1 µM -2.05094954604264 0.0233748941263967 no 3252 0.0201359302077988 1074 4046054 SGTC_1505 k297-0037 20.6 µM -2.05640117793924 0.02307964632918 no 3253 0.0198719314287169 1070 4089396 SGTC_654 1124-0271 80.9 µM -2.06030734395021 0.022870033905766 no 3254 0.0196845841490814 1076 5403748 SGTC_1400 3771-8998 51.5 µM -2.06620400848253 0.0225566469611384 no 3255 0.0194046102645492 1085 670767 SGTC_978 1416-0512 87.4 µM -2.07002250840453 0.0223556447565999 no 3256 0.019225118349253 1083 6814003 SGTC_348 k064-0012 10.7 µM -2.07315546468681 0.0221918592133253 no 3257 0.0190789067788296 1062 5066323 SGTC_1662 st014054 52 µM -2.08249442121335 0.0217096309393551 no 3258 0.0186486659670713 1078 2838777 SGTC_2691 st077356 60.2 µM -2.08327316413423 0.021669822561461 no 3259 0.0186131657048145 1072 2839272 SGTC_2225 6654152 15.4 µM -2.08616180507077 0.0215226970654021 no 3260 0.0184819843778838 1056 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1866 st057638 64 µM -2.088398368932 0.021409364140015 no 3261 0.0183809572511617 1052 688802 SGTC_2726 cimetidine 79.27 µM -2.09340784273547 0.0211573496700991 no 3262 0.0181563814593784 1074 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1627 st003713 25.6 µM -2.10048770509226 0.0208054618560713 no 3263 0.0178429805210437 1060 16195070 YER133W GLC7 SGTC_2460 5552655 174.22 µM -2.10283763615322 0.0206897648408173 no 3264 0.017739982421872 1065 5401989 SGTC_1248 0469-0687 58.6 µM -2.11251512970971 0.020219026949862 no 3265 0.0173211448247464 1066 4017482 SGTC_3 0833-0587 95.581 µM -2.11968787722538 0.0198760138844674 no 3266 0.0170161880049988 1058 5382644 SGTC_207 4185-0010 4.486 µM -2.13110904330299 0.0193400297485447 no 3267 0.016540079936762 1064 3761753 SGTC_1804 st050076 49.1 µM -2.1315800798103 0.0193181907593478 no 3268 0.0165206913946128 1074 3895976 SGTC_889 0919-1524 82.7 µM -2.13504713135865 0.0191580893653847 no 3269 0.0163785802316217 1076 3905452 SGTC_3334 9142812 21.919 µM -2.13911051034587 0.0189718878166233 no 3270 0.0162133596983343 1066 45283678 SGTC_2496 diffractaic acid 79.83 µM -2.14134758612134 0.018870033916547 no 3271 0.0161230091705488 1063 94870 An apoptosis inducer which activates caspases. SGTC_3179 9107801 49.47 µM -2.15135644268874 0.0184200095241046 no 3272 0.0157240381940559 1068 4818259 SGTC_2455 5377712 9.75 µM -2.15328871227231 0.0183341905882023 no 3273 0.0156479976757227 1061 2243908 SGTC_2812 7970281 58.44 µM -2.18126311121738 0.0171294135262054 no 3274 0.0145819806055101 1074 2233435 SGTC_1229 0139-0193 12.2 µM -2.18716128690864 0.0168842198793181 no 3275 0.0143653759463989 1065 3090752 SGTC_1801 st050089 28.441 µM -2.18766235205848 0.0168635290587851 no 3276 0.0143471031685223 1071 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2277 7947813 106.88 µM -2.20673465932584 0.0160919251448359 no 3277 0.0136663011633121 1075 1246798 SGTC_2907 7721985 69.9 µM -2.21455778844387 0.0157842892637751 no 3278 0.0133952160313618 1075 3267881 SGTC_2666 tannic acid 100 µM -2.21877431476939 0.0156205809744325 no 3279 0.0132510411385199 1066 16134267 A thiamine antagonist. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -2.2225250324616 0.0154761844000226 no 3280 0.0131239221239873 1068 5355888 SGTC_2221 6807166 181.081 µM -2.22278433641144 0.0154662441000785 no 3281 0.0131151728958827 1080 674925 SGTC_2981 9013952 38.96 µM -2.2293390677372 0.0152167855599145 no 3282 0.0128956765456919 1064 2996344 SGTC_964 1287-0107 19.4 µM -2.23380044330224 0.0150489791823251 no 3283 0.0127481031867833 1069 51516812 YPR165W RHO1 SGTC_3059 1327-0034 3 µM -2.24435283740465 0.0146583882551631 no 3284 0.0124048542217222 1072 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_214 4373-3496 70 µM -2.24945727169454 0.0144726015625143 no 3285 0.0122417091836096 1080 3779166 SGTC_3286 9117135 37.221 µM -2.2638543043095 0.0139594742456311 no 3286 0.0117915386232901 1071 3438150 SGTC_1078 idebenone 36.1 µM -2.27227437809457 0.0136667023949527 no 3287 0.0115349716715264 1078 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2566 crystal violet carbinol 226 nM -2.29118591858449 0.0130283871503826 no 3288 0.0109763315174448 1066 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_318 1488-0629 67.2 µM -2.2946366478171 0.0129147391299084 no 3289 0.0108769781004157 1082 3662576 SGTC_125 0133-0007 11.75 µM -2.31816815191654 0.0121623572229912 no 3290 0.0102200920862813 1078 26541 SGTC_1362 1611-0397 101 µM -2.32273448168861 0.0120208421696011 no 3291 0.0100967103412627 1079 27816 SGTC_1846 st056244 14.8 µM -2.34610325493639 0.0113187572776843 no 3292 0.00948542557670955 1078 5393182 SGTC_2815 7968870 71.43 µM -2.35317671726096 0.0111133940872053 no 3293 0.00930689279793535 1083 2977326 YHR190W ERG9 SGTC_1567 st069303 68.4 µM -2.35856603005624 0.0109591089347109 no 3294 0.00917284785104632 1081 5581319 SGTC_1019 4262-0212 3.4 µM -2.37765654875514 0.0104274811408376 no 3295 0.00871152275786961 1081 4677213 SGTC_1907 st060210 83.7 µM -2.40545021069707 0.00969371306008204 no 3296 0.00807627641511947 1074 688793 SGTC_1121 fusaric acid 630.51 nM -2.4161046566508 0.00942462960825788 no 3297 0.00784377580408128 1074 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2775 cyproheptadine 69.59 µM -2.42468398616725 0.00921272522075965 no 3298 0.00766085869846683 1084 2913 A selective serotonin reuptake inhibitor. SGTC_2933 9026794 32.47 µM -2.42510564821932 0.00920241879261637 no 3299 0.00765196619838141 1073 17586027 SGTC_1933 st074711 15.9 µM -2.43940885718139 0.00885873984874861 no 3300 0.00735565658688818 1081 17250958 SGTC_2835 9006588 71.43 µM -2.45388880098965 0.00852232409483277 no 3301 0.00706603373546537 1050 2345538 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.49271300456356 0.00767503229275909 no 3302 0.00633856337042579 1082 229346 A bile salt which induces apoptosis. SGTC_1290 0986-0249 10.2 µM -2.49348493528471 0.0076589659453102 no 3303 0.00632479759918807 1078 53329 SGTC_274 sirtinol 40.1 µM -2.50542683729539 0.0074141619651443 no 3304 0.00611518491772091 1081 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1107 amlodipine 47 µM -2.51649573291708 0.00719343882456015 no 3305 0.00592641677231294 991 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2982 9019404 25.97 µM -2.54835192197736 0.00659020867996427 no 3306 0.00541166124972818 1072 22333232 SGTC_127 0180-0333 59.125 µM -2.56900537832603 0.00622343295733104 no 3307 0.00509954372639952 1053 771601 SGTC_2706 st078239 82.5 µM -2.57296407969231 0.00615523386652257 no 3308 0.00504158360545191 1088 15434492 SGTC_2837 9008476 45.46 µM -2.59613869613845 0.00576911394465761 no 3309 0.00471390002002695 1076 2992805 SGTC_1128 3448-9350 235 µM -2.59822784915551 0.00573538530739405 no 3310 0.00468531462158135 1073 619386 SGTC_1276 0871-0068 94.2 µM -2.599061065757 0.00572198221598872 no 3311 0.00467395711657738 1088 3414906 SGTC_1888 azatryptophan 97.5 µM -2.64482285154685 0.00502724412000701 no 3312 0.00408668470830825 1089 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_205 1486-1330 71.903 µM -2.65930049520629 0.00482365945273287 no 3313 0.00391515447810983 1085 4118834 SGTC_1522 st012842 45.6 µM -2.66392265142793 0.00476022841842757 no 3314 0.00386176597693205 1040 3491067 YOR116C RPO31 SGTC_3254 9136651 49.47 µM -2.67682789525315 0.00458704622742274 no 3315 0.00371614008249317 1089 16454030 SGTC_1967 st070177 51.4 µM -2.70274207067432 0.00425618134161072 no 3316 0.00343850441691381 1088 5729214 SGTC_1048 3161-0300 24.5 µM -2.72504391571169 0.00398870030268825 no 3317 0.00321464674125607 1085 2165101 SGTC_504 lovastatin 124 µM -2.72768495578079 0.00395804276571156 no 3318 0.00318902452231863 1085 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1822 st052468 42 µM -2.7315505525598 0.0039135508895229 no 3319 0.00315185346994707 1085 2873678 SGTC_2985 9022375 71.43 µM -2.74308358187258 0.00378345951566153 no 3320 0.00304325955226345 1080 4939335 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.75988418526545 0.00360088468393157 no 3321 0.0028910927897571 1084 756377 SGTC_174 3553-0389 74.3 µM -2.78115627078247 0.00338108032151153 no 3322 0.00270828283521297 1089 738071 SGTC_643 k048-0106 28.4 µM -2.81069631310057 0.00309584222563173 no 3323 0.00247172105930257 1090 6763920 SGTC_473 2-arachidonoylglycerol 10 µM -2.82301614677561 0.00298342549073309 no 3324 0.00237870877737669 1070 5282280 An endocannabinoid. SGTC_1011 4112-3381 17.4 µM -2.8251640642759 0.00296420697820418 no 3325 0.00236282061395923 1088 2877139 SGTC_2939 9044578 71.43 µM -2.85264516956912 0.00272797795478756 no 3326 0.0021678501965166 1088 2653634 SGTC_953 1188-0045 9.7 µM -2.86958279470442 0.00259098369620424 no 3327 0.00205506856128887 1080 6144426 SGTC_1674 st016616 23.6 µM -2.87628726783461 0.00253849667034781 no 3328 0.00201191661941315 1083 625830 SGTC_163 TUB2.036 7.546 µM -2.88351267118219 0.00248300917786411 no 3329 0.00196633412476057 1070 15992207 YJR013W GPI14 SGTC_1504 k297-0033 30 µM -2.89002695806626 0.00243392544996487 no 3330 0.00192604395638991 1078 4388117 SGTC_975 1335-0046 28.5 µM -2.90363472325037 0.00233421507100014 no 3331 0.00184429116832396 1086 16486740 SGTC_3147 9097027 49.47 µM -2.9665907504845 0.00191935082321104 no 3332 0.00150560740106344 1089 25236841 SGTC_2647 atorvastatin 60.16 µM -3.08320994888917 0.00132322129735173 no 3333 0.00102390313363725 1092 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2773 thioridazine 9.09 µM -3.11534240558905 0.00119176667549713 no 3334 0.000918657484571852 1094 5452 An antipsychotic. SGTC_2908 7930301 100 µM -3.125994043687 0.00115090211830453 no 3335 0.000886025704444723 1086 2223178 SGTC_1089 terbinafine 2.25 µM -3.12787546404732 0.00114381893115355 no 3336 0.000880373845174949 1088 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3217 9129673 49.47 µM -3.14542528468009 0.00107964504258614 no 3337 0.000829227751864988 1091 17248312 SGTC_519 k048-0011 62.8 µM -3.18677880288212 0.000941268728071606 yes 3338 0.000719333775728245 1087 6836379 SGTC_1642 st009582 77.7 µM -3.24141732858231 0.000783389362572654 yes 3339 0.000594684630333338 1093 6739311 SGTC_3283 9109332 35.8195 µM -3.29122259681318 0.0006611038565708 yes 3340 0.000498764729746037 1088 17027281 SGTC_1926 methyl fluorone black 53.6 µM -3.33450922352976 0.000569394586119534 yes 3341 0.000427250332450023 1084 72721 Reacts with homocysteine. SGTC_1630 st005209 31.3 µM -3.40711106937726 0.000441540387633591 yes 3342 0.000328272020660428 1087 3367314 SGTC_3140 9094243 49.47 µM -3.42852286612004 0.000409260665460623 yes 3343 0.000303437705193823 1089 19291112 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -3.5088154233619 0.000306721547057997 yes 3344 0.000225053578625234 1089 6857784 SGTC_2993 9054257 71.4286 µM -3.53695630872689 0.000276846480797373 yes 3345 0.000202383309991449 1086 6470217 YGL055W OLE1 SGTC_67 0335-0847 266 µM -3.56114822997721 0.000253353831907733 yes 3346 0.00018461827448877 1091 4552207 YOR254C SEC63 SGTC_3170 9103054 49.47 µM -3.58517011997202 0.00023187626943501 yes 3347 0.000168429275953418 1088 16432970 SGTC_711 k292-0785 179 µM -3.7279300149042 0.000135482585759639 yes 3348 9.65294846644124e-05 1089 4146315 SGTC_1633 st005664 67.9 µM -3.82571496200268 9.27550958985179e-05 yes 3349 6.51965475099953e-05 1093 2063822 SGTC_2951 9072950 58.06 µM -3.94989352034293 5.6606063483735e-05 yes 3350 3.90929837403876e-05 1090 16488155 SGTC_2433 5607874 27.82 µM -4.01506490863868 4.34338081648615e-05 yes 3351 2.9714718522651e-05 1092 2252428 SGTC_1523 st012844 44.7 µM -4.05887560326742 3.62692118847947e-05 yes 3352 2.4654785573305e-05 1089 4274103 SGTC_2949 9072542 2.23 µM -4.14734202382103 2.50666035098343e-05 yes 3353 1.6817870081179e-05 1094 16457352 SGTC_2911 7942208 15.64 µM -4.52877384711945 4.69011326159659e-06 yes 3354 2.96634776776315e-06 1095 1243384 SGTC_2947 9072639 7.68 µM -4.71291427280946 1.98929143828932e-06 yes 3355 1.22099474682789e-06 1092 16488146 SGTC_2282 7944268 200 µM -6.2587849386317 4.22366076617676e-10 yes 3356 1.9399423940636e-10 1095 2970414