SGTCid condition conc unit HUA1|YGR268C.score HUA1|YGR268C.strain.pval HUA1|YGR268C.strain.significant HUA1|YGR268C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2337 9009472 200 µM 6.24458122976747 2.64866932309339e-09 yes 1 2.12468525749697e-10 5 5742383
SGTC_3199 9111318 49.47 µM 5.9094389685182 1.65611803933707e-08 yes 2 1.71637414008968e-09 5 8548020
SGTC_2226 7298446 200 µM 5.66967293308825 5.79613651701628e-08 yes 3 7.1535188098878e-09 1 3283010
SGTC_990 3985-0011 41.3 µM 5.55470134123881 1.03871589794647e-07 yes 4 1.39043406153652e-08 4 5399565 YGL099W LSG1
SGTC_2772 vinpocetine 57.06 µM 5.09835224654822 9.42278122568701e-07 yes 5 1.71311405630561e-07 8 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_704 1310-0270 142 µM 4.9716497544272 1.68468713506554e-06 yes 6 3.31927780548697e-07 14 5718033
SGTC_3059 1327-0034 3 µM 4.92774712212089 2.05392511047568e-06 yes 7 4.15915898786878e-07 36 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1454 4239-0054 42.6 µM 4.81919604430218 3.32934795397534e-06 yes 8 7.20689333342856e-07 13 1340767
SGTC_915 methyl methanesulfonate (MMS) 110 mM 4.48081557735712 1.40828469056181e-05 yes 9 3.71791720459508e-06 28 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1879 gemcitabine 100 µM 4.37976871857281 2.12640751189407e-05 yes 10 5.94026676196495e-06 8 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1619 st003326 88.7 µM 4.34324802274656 2.46271187472924e-05 yes 11 7.01957415998907e-06 12 2849032
SGTC_367 0335-0881 7.1 µM 4.29542409359941 2.97978871205683e-05 yes 12 8.71798453787143e-06 59 23828853
SGTC_402 epigallocatechin gallate 10 µM 4.29201527608687 3.02032500352182e-05 yes 13 8.85293821151485e-06 18 65064 An antioxidant.
SGTC_718 1130-0073 349 µM 4.22342400783946 3.95583180797725e-05 yes 14 1.20309262872095e-05 13 6740020
SGTC_2596 sinensetin 100 µM 4.12327090620033 5.82487134508204e-05 yes 15 1.86764975934406e-05 29 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2801 7907800 81.82 µM 4.10860451587902 6.16014637758167e-05 yes 16 1.99028527656595e-05 24 6620925
SGTC_3340 9146634 11.102 µM 4.03124989852089 8.25080096500922e-05 yes 17 2.77405071721709e-05 12 4907387
SGTC_2163 5671233 125 µM 3.92756721660925 0.000121118612280828 yes 18 4.29047216244e-05 27 701023
SGTC_2873 9040596 71.43 µM 3.92202524522087 0.000123598454362831 yes 19 4.39038947020251e-05 50 6463863
SGTC_2481 5478948 45.16 µM 3.89957283876488 0.00013414068216184 yes 20 4.81812726544348e-05 37 77792
SGTC_1192 1488-0095 21.4 µM 3.88299169218513 0.000142461012182333 yes 21 5.15895473576584e-05 16 915875
SGTC_3019 9081971 49.47 µM 3.86798982689801 0.000150403207011666 yes 22 5.48681209185166e-05 18 16451803
SGTC_2060 5238662 140 µM 3.76406866043541 0.000217896807632994 yes 23 8.35854754646722e-05 32 790130
SGTC_2180 6301957 200 µM 3.74140788887272 0.00023596211679107 yes 24 9.14961232791209e-05 11 845462
SGTC_1241 0364-0022 50.8 µM 3.7398934543787 0.00023721791863224 yes 25 9.20491363517938e-05 39 4563895
SGTC_2253 7938677 135.83 µM 3.72500642230862 0.000249898793908481 yes 26 9.76551247558839e-05 14 2301972
SGTC_2561 acetosyringone 100 µM 3.70019667498613 0.000272445261555716 yes 27 0.000107716220213987 34 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3197 9113331 49.47 µM 3.6907035620998 0.000281563020007855 yes 28 0.000111817319500035 39 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_52 0329-0193 875 nM 3.63685627176848 0.000338889435170334 yes 29 0.000137992912633239 45 3739292
SGTC_288 1315-0019 35.1 µM 3.59175681289785 0.000395064582604839 yes 30 0.000164228141565971 30 6811474
SGTC_55 0767-0285 6.563 µM 3.57218070325182 0.000422041518676249 yes 31 0.000177010493643527 52 3116166
SGTC_797 k781-0471 270 µM 3.44595996440912 0.000641269536647906 yes 32 0.000284517328041584 37 23738129
SGTC_2526 patulin 37.61 µM 3.43354909898581 0.000667726938882888 yes 33 0.00029786714903399 127 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_701 4424-0219 185 µM 3.41521352943127 0.000708661715181989 yes 34 0.000318660144356059 29 2911779
SGTC_2874 9043904 71.43 µM 3.40863129093452 0.00072391252505864 yes 35 0.000326448296115639 28 4463428
SGTC_2896 9052656 71.43 µM 3.40491028874085 0.000732667227751343 yes 36 0.00033092896480447 157 6469436
SGTC_1154 4088-0362 150 µM 3.35351280160236 0.000864004566183077 yes 37 0.000398963613166059 45 6618304
SGTC_936 3005-4620 401 µM 3.32131065143075 0.000956982524882888 yes 38 0.000447978763654487 52 777207
SGTC_925 2064-1272 59.6 µM 3.31745275593506 0.000968717486114598 yes 39 0.000454211387066362 41 6815817
SGTC_1155 4088-0394 48.2 µM 3.30419402757358 0.00101006251828734 no 40 0.000476249426468611 55 2326248
SGTC_1698 5-fluorocytosine 1.055 µM 3.22798893118725 0.00128075497601391 no 41 0.000623318989027706 23 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1436 4092-1007 8.32 µM 3.22644722215418 0.00128685922655083 no 42 0.000626686725954915 33 2881121
SGTC_413 propylparaben 100 µM 3.20074029094797 0.00139264230921333 no 43 0.000685375107997882 47 7175 A pharmaceutical preservative.
SGTC_427 1354-0053 47.3 µM 3.19757606076326 0.00140619790427635 no 44 0.000692939287485004 54 6813657
SGTC_10 0279-0212 42.575 µM 3.18705594941041 0.00145213697785967 no 45 0.000718644844161709 184 39851 YBR002C RER2
SGTC_2880 9042983 58.44 µM 3.16620930174809 0.00154723973578065 no 46 0.000772198126272114 60 6464714
SGTC_3074 9116018 49.47 µM 3.16557815260332 0.00155020566274673 no 47 0.000773875387543897 43 17027303
SGTC_1634 st006576 41 µM 3.15623679391956 0.00159471341231373 no 48 0.000799095281367857 47 3915356
SGTC_2039 Aminomethylbenzodioxan 200 µM 3.15177118510241 0.00161639897908535 no 49 0.000811416947115959 21 15053
SGTC_1396 3511-0007 98.6 µM 3.14405114700648 0.00165452316659944 no 50 0.000833131568152681 36 X1396
SGTC_1433 4060-0023 7.6 µM 3.13108419772145 0.00172040553397785 no 51 0.000870811099622151 45 3840627
SGTC_624 k048-0052 28 µM 3.13014138993434 0.00172528763810527 no 52 0.000873610922034199 45 6835531
SGTC_2597 laccaic acid a 100 µM 3.12233331686051 0.00176620710176004 no 53 0.000897118368577861 66 5491415 A textile dye.
SGTC_1328 1441-0025 69.2 µM 3.11159514018187 0.00182392480842003 no 54 0.000930397513537375 31 4562601
SGTC_2162 5663267 200 µM 3.10662331883089 0.00185122487576782 no 55 0.000946186802769127 37 6456493
SGTC_411 enrofloxacin 100 µM 3.10473891814882 0.0018616687544022 no 56 0.000952235241936119 28 71188 A bacterial gyrase inhibitor.
SGTC_467 ro 31-8220 72.8 µM 3.07193003074635 0.00205229966429865 no 57 0.00106339785887394 132 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_459 nigericin 15.3 µM 3.07124820061228 0.00205644277848251 no 58 0.00106582936857095 109 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2894 9048625 32.47 µM 3.0635672514012 0.00210364291918935 no 59 0.00109357519618404 43 4092861
SGTC_145 3737-0113 38.366 µM 3.04198867655024 0.00224155023471109 no 60 0.00117510367681404 128 6849351
SGTC_1209 2323-2347 50.3 µM 3.04006771431971 0.00225421560579212 no 61 0.00118262481885392 41 5412760
SGTC_810 3825-7150 143 µM 3.02468638507665 0.00235798971093747 no 62 0.00124445531029736 36 22330411 YGL099W LSG1
SGTC_1100 amiodarone 5.07 µM 3.01494597716249 0.00242592285927105 no 63 0.00128512515719335 53 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1518 st038567 90.8 µM 3.00247027304689 0.00251551772796326 no 64 0.00133899063336162 52 77966
SGTC_1026 k007-1105 30.6 µM 2.97764029650974 0.0027027910864723 no 65 0.00145238333857787 154 7066794
SGTC_2129 girgensonine 121.053 µM 2.93885633165923 0.00302058384059189 no 66 0.00164712868847812 88 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2085 5307070 144.047 µM 2.93409369089529 0.00306184464990353 no 67 0.00167261607034834 67 2840351
SGTC_426 0988-0037 14.6 µM 2.90809311611711 0.00329617878453442 no 68 0.001818200213168 91 5383008
SGTC_1688 st021091 57.6 µM 2.89503883916477 0.00341980996062135 no 69 0.00189555811117531 25 3656366
SGTC_706 4262-0057 46.9 µM 2.89259651364404 0.00344339749709411 no 70 0.00191035887625632 93 883298
SGTC_3300 9124615 50.48 µM 2.88580148082426 0.00350979361001312 no 71 0.00195209167398455 75 24824903
SGTC_552 k242-0005 476 µM 2.87143682705763 0.00365395225733439 no 72 0.00204305222101508 59 4088318
SGTC_3110 9122132 49.47 µM 2.85576458023191 0.00381727387504977 no 73 0.00214666672985025 57 918317
SGTC_3326 9140064 16.379 µM 2.84717547127917 0.00390953060720116 no 74 0.002205452099645 65 1868434
SGTC_601 0986-0029 62.9 µM 2.84440758273518 0.00393968361604633 no 75 0.00222470456408119 101 24747981
SGTC_515 4092-1064 102 µM 2.83768220519726 0.00401381874556347 no 76 0.00227212010732244 127 717353
SGTC_3067 9117431 49.47 µM 2.8359266710759 0.00403337478650263 no 77 0.00228464679138363 59 17150885
SGTC_1795 st049545 62.3 µM 2.82335726897017 0.00417590328079557 no 78 0.00237617905222345 57 5291882
SGTC_1163 k060-0048 49.9 µM 2.81723592376717 0.00424693312698482 no 79 0.00242194649738599 88 6809982
SGTC_340 k038-0059 454 µM 2.81634101006419 0.00425740740050959 no 80 0.00242870391195639 91 23733424
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.80337005018275 0.00441183752083309 no 81 0.00252858037331327 102 4174840
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.79709530027045 0.00448832445573828 no 82 0.00257821606080693 77 75037 A free radical scavenger.
SGTC_206 4546-0025 72.014 µM 2.79568540714885 0.00450567262601113 no 83 0.00258948930002977 148 6620745 YIL048W NEO1
SGTC_1707 st032323 6.317 µM 2.78727580193534 0.00461039870239403 no 84 0.00265766098542434 133 3132057 YMR211W DML1
SGTC_2455 5377712 9.75 µM 2.76940037016524 0.0048402501355661 no 85 0.00280797885512597 79 2243908
SGTC_202 3594-0513 34.79 µM 2.75724874236275 0.00500228006796265 no 86 0.0029144995631884 46 708429
SGTC_1239 0337-0584 35.4 µM 2.75429929492023 0.00504232942922308 no 87 0.00294089765586056 134 914301 YML130C ERO1
SGTC_693 4161-2696 114 µM 2.75161358433221 0.00507904572922855 no 88 0.00296512251850385 45 805759
SGTC_2432 5630864 12.22 µM 2.74878521476827 0.00511796947501802 no 89 0.00299082842999909 107 5714970
SGTC_851 0394-0702 453 µM 2.74309565533036 0.00519707384815155 no 90 0.00304314765782764 67 762646
SGTC_789 1309-1135 70.6 µM 2.73896179319145 0.00525522922083877 no 91 0.00308167677564561 98 3092424
SGTC_848 0368-0089 85.6 µM 2.72163292648837 0.00550536091173871 no 92 0.00324801269805125 80 762535
SGTC_1403 3909-7815 62.9 µM 2.70952357473549 0.00568637583320032 no 93 0.00336899582633616 64 6615483
SGTC_2412 st077135 33.4 µM 2.68281380320591 0.00610443755756638 no 94 0.00365028121279299 110 13258915
SGTC_2174 5790901 200 µM 2.67701809060689 0.00619866928241516 no 95 0.00371403120704482 107 786020
SGTC_3073 9114972 49.47 µM 2.66915273939629 0.00632861077590161 no 96 0.0038021430507596 76 41905075
SGTC_2766 oltipraz 83.91 µM 2.66742713933015 0.0063574394527121 no 97 0.00382172301399086 101 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3196 9111891 49.47 µM 2.66607987118546 0.00638002827928956 no 98 0.00383707291499517 64 18891510
SGTC_991 3996-0057 64.7 µM 2.65060512417169 0.00664462245324212 no 99 0.00401738593317244 82 715343
SGTC_2453 5731132 22.18 µM 2.63874306312272 0.00685396646044603 no 100 0.00416070115005271 108 1362040
SGTC_1915 st067105 30.6 µM 2.63225437188455 0.00697092746341071 no 101 0.00424101654204656 141 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2102 5377816 72.7585 µM 2.59926372071908 0.0075932610441699 no 102 0.00467119846019781 102 1379702
SGTC_2665 lovastatin 100 µM 2.58550430304526 0.00786695035040118 no 103 0.00486183295387112 95 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_154 3389-1638 511.116 µM 2.58527472548689 0.00787158955390984 no 104 0.00486507168921109 105 5238686
SGTC_421 streptovitacin 30 mM 2.57714492499357 0.00803743204166202 no 105 0.00498100865473731 114 91467 include heat shock
SGTC_3235 9132602 49.47 µM 2.56751490853608 0.00823784550296059 no 106 0.00512151923410577 122 4912240
SGTC_2389 9091542 195.52 µM 2.55831005401902 0.0084335004836896 no 107 0.00525911322051157 129 3626624 YOL127W RPL25
SGTC_2132 5317594 122.667 µM 2.55089145444239 0.00859414400730215 no 108 0.00537238920865637 100 794577
SGTC_2511 berberine 10.47 µM 2.53367131284909 0.00897741668551932 no 109 0.00564372758123609 95 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2580 diallyl disulphide 81.36 µM 2.53316590307722 0.0089888883696417 no 110 0.00565187194505907 109 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1003 4049-0218 100 µM 2.53064856248693 0.00904621789201373 no 111 0.00569259295115707 132 295161
SGTC_1846 st056244 14.8 µM 2.52571432242499 0.00915951909419101 no 112 0.00577316648117806 136 5393182
SGTC_2643 anethole 100 µM 2.51837441421696 0.00933035801116316 no 113 0.005894895962699 111 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_4 0960-0234 25.671 µM 2.50784359837238 0.00958033352103625 no 114 0.00607352096883977 88 6821112
SGTC_2830 7992007 71.43 µM 2.50611988567891 0.0096218029411102 no 115 0.00610321123281716 110 1952075
SGTC_3032 9089427 49.47 µM 2.50532556116969 0.00964096570497564 no 116 0.00611693639085291 98 17173707
SGTC_2712 st079126 47.7 µM 2.47876733831999 0.0103011651917802 no 117 0.00659186358603542 113 3152970
SGTC_128 0906-2981 13.371 µM 2.4633119405849 0.0107032353885904 no 118 0.00688300451002689 96 6740226
SGTC_3184 9108758 49.47 µM 2.46081897486898 0.0107693534921061 no 119 0.0069310144441206 63 902885
SGTC_2295 7971645 200 µM 2.44613658297272 0.0111660176430389 no 120 0.0072198143760247 134 2978226 YKL099C UTP11
SGTC_1143 3454-2408 5.08 µM 2.44554555694577 0.0111822475458852 no 121 0.00723165874218269 58 X1143
SGTC_1925 st057770 10.1 µM 2.41306942840448 0.0121061654955403 no 122 0.00790940298368263 117 5989122
SGTC_2581 avocatin a 64 µM 2.41130481969465 0.0121582096959037 no 123 0.00794777862746702 165 6710728 A skin care supplement.
SGTC_651 3253-0966 34.4 µM 2.4037209787731 0.0123840961631806 no 124 0.00811457751968967 143 781462
SGTC_1637 st007924 17.4 µM 2.403467942421 0.0123916951625794 no 125 0.0081201954396221 130 683336
SGTC_2645 abamectin 100 µM 2.39714439725112 0.0125829151276784 no 126 0.00826170535953371 129 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1414 3917-0015 5.4 µM 2.38951198457814 0.0128171119049418 no 127 0.0084353867117341 100 6618702
SGTC_1391 3442-0225 151 µM 2.3865409100831 0.0129092922175773 no 128 0.00850385748517243 106 5227075
SGTC_2487 5918373 44.05 µM 2.38245943261849 0.0130368582225579 no 129 0.0085987133484877 128 2876279
SGTC_416 estradiol valerate 100 µM 2.38147167750702 0.0130678936398138 no 130 0.00862180835690122 120 13791 A steroid.
SGTC_2402 5553605 200 µM 2.37174361912992 0.0133769777932697 no 131 0.00885218543660968 156 6758546
SGTC_3327 9140648 26.9345 µM 2.37141099657027 0.0133876567107285 no 132 0.00886015699828018 100 8029710
SGTC_49 0717-0965 32.132 µM 2.36246834790364 0.0136775346843111 no 133 0.00907684579163315 139 5889349 YGL099W LSG1
SGTC_3072 9116419 49.47 µM 2.35953904266339 0.0137736589410335 no 134 0.00914882767246514 131 17170162
SGTC_31 0508-1974 57.237 µM 2.35392711332036 0.0139594410117159 no 135 0.0092881265598159 132 6810525
SGTC_719 2810-4230 27.3 µM 2.33048679314929 0.0147589695092023 no 136 0.00989021862030099 67 721079
SGTC_1523 st012844 44.7 µM 2.32741490781727 0.0148666132660966 no 137 0.00997159653687371 151 4274103
SGTC_2605 digitonin 300 nM 2.32620343546869 0.0149092504280308 no 138 0.0100038502441836 184 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3270 9137563 49.47 µM 2.32475347260632 0.0149604193225504 no 139 0.0100425731015674 108 17015724
SGTC_1975 st070967 30.8 µM 2.31778741930824 0.0152083599714452 no 140 0.0102304385862904 180 261391
SGTC_1210 3013-0140 750 nM 2.31677625992717 0.0152446416391536 no 141 0.0102579614466294 98 905973
SGTC_3040 9091894 49.47 µM 2.30788063890381 0.0155670441159195 no 142 0.0105028880983131 105 25236966
SGTC_506 n9-isopropylolomoucine 153 µM 2.30083655655353 0.0158264764709268 no 143 0.0107004356383819 128 6610355
SGTC_2362 9071156 126 µM 2.29448806772595 0.0160634582360018 no 144 0.0108812398399191 129 653133
SGTC_2059 5238311 157 µM 2.29101328459077 0.0161944510159589 no 145 0.010981322668173 162 703021
SGTC_923 1900-2434 73.3 µM 2.28480974320734 0.0164305887839211 no 146 0.0111619930557431 172 5910570
SGTC_1289 0976-0073 69.1 µM 2.28146206628997 0.0165592383871835 no 147 0.0112605594703498 129 3391136
SGTC_321 4534-3890 65.3 µM 2.26841130894315 0.0170690366892012 no 148 0.0116520745673698 110 699746
SGTC_1188 1403-0014 4.57 µM 2.26703606345557 0.0171235306849745 no 149 0.0116940113775301 229 9614867
SGTC_9 0092-0002 10.449 µM 2.26209952951349 0.0173203668351467 no 150 0.0118456273366515 155 759368
SGTC_334 1502-1024 68.5 µM 2.25044674951551 0.0177926811343144 no 151 0.0122103001056566 154 3296216
SGTC_446 go6976 132 µM 2.24702703571354 0.0179333585209058 no 152 0.0123191496694618 126 3501 A protein kinase C inhibitor.
SGTC_647 0140-0236 81 µM 2.23829895687319 0.0182967134889419 no 153 0.0126007830511149 162 990837
SGTC_2269 7935389 174.42 µM 2.20449866363416 0.0197635896943805 no 154 0.0137446469154367 170 97605
SGTC_1276 0871-0068 94.2 µM 2.20405879630139 0.0197833187415492 no 155 0.0137601046933771 142 3414906
SGTC_1855 st056195 39.6 µM 2.20043053587273 0.0199466929787053 no 156 0.0138881816600683 165 4028379
SGTC_1097 itavastatin 7.23 µM 2.18739252391785 0.020543251138518 no 157 0.014356940736979 191 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2385 9074692 200 µM 2.18535948025394 0.0206376225185121 no 158 0.0144312496866428 200 17046906
SGTC_1950 st077106 7.18 µM 2.18487486009849 0.020660172107059 no 159 0.0144490116339901 190 13831864
SGTC_3268 9137683 49.47 µM 2.1810387727523 0.0208394043698972 no 160 0.0145902744007607 105 1953228
SGTC_293 4049-0273 38.5 µM 2.17309233906535 0.0212148734599347 no 161 0.0148866840959638 136 1380311
SGTC_2998 9066762 71.4286 µM 2.172718401324 0.0212326820878266 no 162 0.014900758979946 201 4945196
SGTC_1333 1482-0047 286 µM 2.16873906291547 0.0214229808740435 no 163 0.015051249961208 194 3811116
SGTC_2822 7994718 71.43 µM 2.16687240107366 0.0215127434802764 no 164 0.0151222924521042 142 1018011
SGTC_2551 apiole 73.87 µM 2.16142698017844 0.0217764169505952 no 165 0.0153311859218654 91 10659 A possible DNA adduct former.
SGTC_1299 1079-1439 3.74 µM 2.16084617614554 0.0218047005716067 no 166 0.015353611883086 155 323161
SGTC_1594 piperine 70.1 µM 2.15489681458086 0.0220962096574449 no 167 0.015584954859715 185 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1940 st075990 51.1 µM 2.15402709381045 0.0221390989176663 no 168 0.0156190236127908 205 1084979
SGTC_1998 st075797 76.8 µM 2.15301113348747 0.0221892887613134 no 169 0.0156589017770332 197 24208315
SGTC_1355 1499-0035 1.68 µM 2.14939800639346 0.0223685608290873 no 170 0.0158014316762237 188 1548538
SGTC_1497 4476-2978 41.3 µM 2.14213194778823 0.0227327804499262 no 171 0.0160914328601709 226 1528379
SGTC_1139 k015-0024 46.9 µM 2.13921538519439 0.0228803758277484 no 172 0.0162091143658932 138 2766652
SGTC_920 mycophenolic acid 780.421 nM 2.13531397895986 0.0230790717130719 no 173 0.0163676859155793 208 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2862 9027634 71.43 µM 2.13319301684545 0.0231876991666757 no 174 0.0164544478714141 186 5012562
SGTC_2393 9031399 185.94 µM 2.13102715038523 0.0232990703283419 no 175 0.0165434527539773 206 1526623 YDL150W RPC53
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.11767952285482 0.0239954003412263 no 176 0.017101109113254 265 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_457 grayanotoxin iii 135 µM 2.10481741967031 0.0246828639705259 no 177 0.0176536021188421 296 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3259 9138485 49.47 µM 2.09925617749787 0.0249851821487159 no 178 0.0178971621131532 199 17646153
SGTC_2409 alverine citrate 63.97 µM 2.08923201555662 0.0255379534114414 no 179 0.0183434213923299 238 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_234 nsc-17383 10.7 µM 2.08408338822677 0.0258258264548069 no 180 0.0185762914042867 212 408974
SGTC_2158 5657123 3.6195 µM 2.07861828098491 0.0261343606777102 no 181 0.0188262246809413 145 2858827
SGTC_551 k048-0028 34.9 µM 2.06639950693487 0.0268353365607218 no 182 0.0193953862306503 210 6836383
SGTC_3181 9108277 49.47 µM 2.0645176769955 0.02694467739118 no 183 0.0194843298168269 191 17097298
SGTC_1943 st076331 65.2 µM 2.04598452398655 0.0280415162789212 no 184 0.0203789466663655 186 24208415
SGTC_222 nsc-310342 10.666 µM 2.04000402754422 0.0284032958199555 no 185 0.0206749622948387 109 432556
SGTC_3105 9121040 49.47 µM 2.03676060785331 0.0286011196545831 no 186 0.0208370188087157 81 41448907
SGTC_3266 9136860 49.47 µM 2.03510957958643 0.0287022591017135 no 187 0.0209199241537646 230 4871271 YPR165W RHO1
SGTC_1658 st012944 20 µM 2.03492090353039 0.0287138360184162 no 188 0.0209294161553923 237 24207260
SGTC_2920 7982904 15.77 µM 2.03331079536772 0.0288127881908543 no 189 0.0210105666021057 209 6456808
SGTC_1189 1431-2119 7.28 µM 2.03291134158569 0.0288373812039056 no 190 0.0210307404931983 272 3107275
SGTC_2131 toluylene red 5.2905 µM 2.01107250400822 0.0302087208769136 no 191 0.0221588994880012 240 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_35 0133-0054 64.071 µM 2.00150522903545 0.030826287999426 no 192 0.0226689854138019 211 99677
SGTC_3064 1327-0027 10 µM 1.9931237141755 0.0313758685203323 no 193 0.023123950924457 105 16000455 YPR107C YTH1
SGTC_1115 galangin 695.678 nM 1.98809543669829 0.0317094461925268 no 194 0.0234005679862802 236 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2307 7538926 6.34 µM 1.98728435107719 0.0317635273785343 no 195 0.0234454474186686 270 96582
SGTC_2648 atorvastatin 78.68 µM 1.98356667410146 0.032012388912231 no 196 0.023652083712095 184 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_203 k066-0004 30.888 µM 1.97332346289059 0.0327064103928503 no 197 0.0242293607041759 278 6795412
SGTC_931 2812-0076 566 µM 1.9699348388445 0.0329387173685266 no 198 0.0244229195009916 236 3450959
SGTC_2911 7942208 15.64 µM 1.96589724828592 0.0332172879787899 no 199 0.0246552405013263 202 1243384
SGTC_1345 1488-0192 31.4 µM 1.96574054278882 0.0332281387612122 no 200 0.0246642945111479 221 658348
SGTC_597 k018-0003 82.8 µM 1.95228078594509 0.0341710873281143 no 201 0.0254524386839509 227 6786234
SGTC_3171 9103192 49.47 µM 1.92399745444609 0.0362242718454309 no 202 0.027177451271597 181 13018434
SGTC_2144 5628481 200 µM 1.92170489592572 0.0363950303540627 no 203 0.0273214504317407 232 2818399
SGTC_99 0109-0120 622.8 µM 1.92085972798716 0.0364581476524002 no 204 0.0273746970362381 199 759414
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.91971755567275 0.0365435875836303 no 205 0.02744679275375 218 279621
SGTC_2908 7930301 100 µM 1.91476089442275 0.0369162695350003 no 206 0.0277615018603106 286 2223178
SGTC_2155 5570423 76 µM 1.91387943540956 0.0369828690847672 no 207 0.0278177812962754 222 797402
SGTC_2887 9044784 58.44 µM 1.91337627621902 0.0370209298129112 no 208 0.0278499496225323 275 6465546
SGTC_975 1335-0046 28.5 µM 1.90710843485411 0.0374977403647196 no 209 0.0282532736063294 283 16486740
SGTC_1277 0873-0036 22 µM 1.90387845674634 0.0377454041716969 no 210 0.0284630077220422 294 5965735
SGTC_1386 3228-0095 33.8 µM 1.90290661361505 0.0378201825775894 no 211 0.0285263659261218 225 870181
SGTC_742 0kpi-0133 140 µM 1.90068836764675 0.0379913183416313 no 212 0.0286714215401382 264 2728852
SGTC_1503 4585-0012 61.3 µM 1.89561366185432 0.0383852039785711 no 213 0.0290055747008084 225 2922052
SGTC_1622 st003707 19.4 µM 1.88967171508723 0.0388506269646121 no 214 0.029400939621972 310 10140899
SGTC_2691 st077356 60.2 µM 1.88280338835207 0.0393943278373525 no 215 0.0298635088547291 269 2839272
SGTC_2796 7949634 45.45 µM 1.8818362098904 0.0394713851326359 no 216 0.0299291288649404 260 2971588
SGTC_2825 7998094 58.44 µM 1.87678952547124 0.0398754572441022 no 217 0.0302734733210378 250 2987815
SGTC_1597 7-benzyloxygramine 47.5 µM 1.86659024493205 0.0407023453010493 no 218 0.0309794154507403 453 260807
SGTC_2369 9071472 200 µM 1.86132596261011 0.0411345511120979 no 219 0.0313490794643407 265 17296037
SGTC_23 0213-0011 39.996 µM 1.86020654209519 0.0412269354046171 no 220 0.0314281549179347 256 627608
SGTC_824 1304-0008 100 µM 1.85206473337186 0.0419039396567296 no 221 0.0320082639684411 313 768245
SGTC_1404 3909-7820 48.3 µM 1.84765645765587 0.0422742341738042 no 222 0.0323260283641997 241 23741373
SGTC_688 0527-0193 473 µM 1.84626448106112 0.0423917084565813 no 223 0.0324269061961861 219 4007154
SGTC_3109 9122853 49.47 µM 1.83737117325054 0.0431484952361632 no 224 0.0330775596931042 234 1234709
SGTC_2283 7944793 200 µM 1.83662392768076 0.0432125768565963 no 225 0.0331327162369613 300 2970533
SGTC_2959 9079155 11 µM 1.82653055707682 0.0440857086468853 no 226 0.0338851913893549 234 16189457
SGTC_1963 st076565 50.3 µM 1.82443928031967 0.0442683825924784 no 227 0.0340428440629109 243 4914280
SGTC_520 3584-0023 682 µM 1.81863274640374 0.044778786073101 no 228 0.034483739215908 271 1340790
SGTC_1343 1487-0095 224 µM 1.81861118139095 0.0447806904664154 no 229 0.03448538536844 247 4560101 YGL055W OLE1
SGTC_761 k216-0224 480 µM 1.8121323166134 0.0453557947209991 no 230 0.034982877018931 279 1340404
SGTC_1112 tnp00069 1.16933 µM 1.80375247632303 0.0461084362607061 no 231 0.035635059489117 312 145826
SGTC_757 1066-0008 322 µM 1.80356136484566 0.0461257173750505 no 232 0.0356500486785319 290 6842497
SGTC_1086 cerivastatin 2.18 µM 1.80222318993272 0.0462468666399796 no 233 0.0357551487872258 229 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3062 9077494 49.47 µM 1.80187383271293 0.046278537094502 no 234 0.035782629022 282 16459633
SGTC_639 0833-0042 114 µM 1.79846864935592 0.0465881418115585 no 235 0.0360513862213253 326 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_235 0330-0087 5 mM 1.7962513438297 0.0467906347898963 no 236 0.0362272761608492 315 46494818 YHR062C RPP1
SGTC_2426 5582046 32.21 µM 1.78337421514457 0.0479806188564558 no 237 0.037262703847666 310 2251934
SGTC_809 3998-0021 90 µM 1.77287911074153 0.0489682906664243 no 238 0.0381243703893894 250 715485
SGTC_1952 st077036 64.1 µM 1.76819565210008 0.049414251104264 no 239 0.0385141004122401 315 2937007
SGTC_1961 st076550 68.7 µM 1.74792643422198 0.051381792121346 no 240 0.0402383834178612 266 1579337
SGTC_2313 7726885 200 µM 1.74403642946504 0.0517664293389014 no 241 0.0405763688646291 310 726423
SGTC_2118 5526350 200 µM 1.73720776784649 0.0524471677376252 no 242 0.0411752521574319 322 743594
SGTC_131 0141-0277 33.849 µM 1.73339185927954 0.0528306534253185 no 243 0.0415130217679621 338 1547771
SGTC_207 4185-0010 4.486 µM 1.73328994033198 0.0528409263467993 no 244 0.0415220739333256 398 3761753
SGTC_144 4161-2749 112.381 µM 1.73268108912479 0.0529023285238443 no 245 0.0415761837711937 261 797501 YMR168C CEP3
SGTC_418 lividomycin a 100 µM 1.72516574102407 0.0536649152295572 no 246 0.0422488038708039 300 72394 An antibiotic.
SGTC_278 4092-0821 23.9 µM 1.72368448734744 0.053816241132937 no 247 0.0423824084782 300 877900
SGTC_870 0573-2213 57.6 µM 1.72356968012769 0.0538279840138002 no 248 0.0423927779976179 274 3916321
SGTC_1046 2001-0062 216 µM 1.71894226991888 0.0543029828738722 no 249 0.0428124421661118 322 739778
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.7163110213247 0.0545745531726259 no 250 0.0430525660914548 351 688667
SGTC_2787 5284540 71.43 µM 1.71423828045273 0.0547892353906236 no 251 0.0432424865515881 315 736958
SGTC_218 alverine citrate 93.75 µM 1.7122611859342 0.0549946326618793 no 252 0.043424273082016 278 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3126 9127922 49.47 µM 1.71077405498776 0.0551495289583581 no 253 0.0435614154221308 345 45595682
SGTC_3237 9133362 49.47 µM 1.70813794621021 0.0554249469771589 no 254 0.043805374689731 318 43845137
SGTC_3102 9121669 49.47 µM 1.70695953148106 0.0555484173001258 no 255 0.0439147872390938 257 41905072
SGTC_97 0535-0701 19.132 µM 1.70636548598631 0.0556107416472913 no 256 0.0439700262234566 284 2832013 YGL099W LSG1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.70296169351483 0.0559689157094431 no 257 0.0442876186653393 317 7104
SGTC_1173 0443-0020 122 µM 1.70033582093589 0.056246472268435 no 258 0.0445338881237195 349 5331295
SGTC_2164 5685496 200 µM 1.69625326205488 0.0566801554153103 no 259 0.0449189637889353 316 759046
SGTC_2687 chenodiol 100 µM 1.69293412533982 0.0570346793559601 no 260 0.0452340034172504 298 5702181 A cholesterol synthesis inhibitor.
SGTC_2141 5621638 7.665 µM 1.69151107264237 0.0571872122836723 no 261 0.0453696174141045 308 2856238
SGTC_1647 st011722 22.4 µM 1.68624438044681 0.0577545284736521 no 262 0.0458743695039708 296 2854783
SGTC_1374 2889-5571 141 µM 1.68579864976947 0.0578027439588746 no 263 0.0459172939763282 377 2853281
SGTC_1540 guanosine 70.6 µM 1.6856771405217 0.0578158933195274 no 264 0.0459290010789061 282 6802 Guanosine is a purine nucleoside
SGTC_787 4152-0075 138 µM 1.68330521923522 0.0580730467125712 no 265 0.0461580102852475 338 9566539
SGTC_1650 st011916 45.8 µM 1.67763283702272 0.0586916666192613 no 266 0.0467093991405033 281 242528
SGTC_2552 juarezic acid 87.02 µM 1.67763114276731 0.0586918521614364 no 267 0.0467095646180564 391 1549512
SGTC_1715 st032160 10.2275 µM 1.67608971162007 0.0588608490108554 no 268 0.0468603108410121 312 5289825
SGTC_806 3966-4455 5.86 µM 1.67377662886554 0.0591151630458949 no 269 0.0470872535827191 303 714982
SGTC_2320 7373003 200 µM 1.6710816291002 0.0594125534393754 no 270 0.0473527777364781 331 5415828
SGTC_1261 0712-0010 12.7 µM 1.66499280482412 0.060088766508981 no 271 0.047957095661521 379 2840123
SGTC_2265 7929201 200 µM 1.66489666296443 0.0600994919650452 no 272 0.0479666870512227 341 1265108
SGTC_3020 9089140 49.47 µM 1.66387848940828 0.060213170046704 no 273 0.0480683572481621 356 17217859
SGTC_1254 0550-0035 264 µM 1.66071678522475 0.0605672443182018 no 274 0.0483851703270616 372 15121435
SGTC_803 4488-1585 147 µM 1.65999724153938 0.060648051964005 no 275 0.0484575037308942 303 747204
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.65420807925683 0.0613012703259904 no 276 0.049042620930281 306 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1457 k015-0032 57.3 µM 1.65101416570617 0.0616640002589617 no 277 0.0493678411993588 373 4302660
SGTC_1558 st069300 45.6 µM 1.65071957698829 0.0616975406749791 no 278 0.0493979242215697 244 24208000
SGTC_1121 fusaric acid 630.51 nM 1.64608990118102 0.062226525594888 no 279 0.0498726256492538 368 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_103 0844-0104 51.839 µM 1.64504448485843 0.0623464626560101 no 280 0.0499803188371125 500 5375804
SGTC_2621 lithochol-11-enic acid 100 µM 1.64419240242427 0.0624443524643178 no 281 0.0500682329090028 395 6708711
SGTC_2557 derrustone 83.84 µM 1.6412285251194 0.0627857852770201 no 282 0.0503749932655001 414 629853 An antioxidant.
SGTC_301 4119-0100 24.5 µM 1.6383470866309 0.0631191142066028 no 283 0.0506746551988855 414 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1142 3253-1408 9.78 µM 1.63623366381355 0.0633644728862611 no 284 0.0508953467419095 337 256655
SGTC_60 0986-0278 202 µM 1.63275152281655 0.0637703520702585 no 285 0.0512606332155828 252 3110598
SGTC_335 4077-0256 27.6 µM 1.62978848813642 0.0641173142257336 no 286 0.0515731038237682 388 3121989
SGTC_2008 4012253 172 µM 1.62910249194547 0.0641978510800823 no 287 0.0516456618984937 396 603940
SGTC_1021 4476-0760 85.3 µM 1.62757191497698 0.0643778262538634 no 288 0.0518078441400446 375 746768
SGTC_2247 cerulenin 830 nM 1.62688037585123 0.0644592703895925 no 289 0.0518812533031638 363 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3002 9075603 71.4286 µM 1.61685417450657 0.0656490926562622 no 290 0.0529548810887771 361 20105405
SGTC_2528 xanthyletin 44.79 µM 1.61397998043958 0.0659932984040167 no 291 0.0532658843639217 315 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1190 1486-1332 13 µM 1.60429295012251 0.067163695879079 no 292 0.0543247471713443 354 4150046
SGTC_3191 9110352 49.47 µM 1.59524838257723 0.0682708987503997 no 293 0.0553283516472136 318 17122424
SGTC_2782 7736369 71.43 µM 1.58964834821506 0.068963462623029 no 294 0.055957046235955 412 2950836 YOL077C BRX1
SGTC_1561 5-methoxyflavone 52.9 µM 1.58362814050516 0.0697140165797299 no 295 0.0566391831149599 277 94525
SGTC_2663 amphotericin b 100 µM 1.58233830567477 0.0698756383496291 no 296 0.0567861802474308 360 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2657 nystatin 74.44 µM 1.5790395986273 0.0702902920088569 no 297 0.0571634872669467 374 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1231 0242-0792 125 µM 1.57530983875712 0.0707614062274722 no 298 0.0575924720360055 371 3707635
SGTC_353 1988-1175 58.3 µM 1.57437743656662 0.0708795582395466 no 299 0.0577001085064918 349 2788357
SGTC_760 0568-0725 82.9 µM 1.57415790087211 0.0709073993637081 no 300 0.0577254746907869 369 3916171
SGTC_955 1216-0110 33 µM 1.57373123242501 0.0709615327210027 no 301 0.0577747990455102 477 3619719
SGTC_1484 3473-2379 286 µM 1.56826955247077 0.071657287671325 no 302 0.0584091192493062 448 671917
SGTC_1604 st002052 72.4 µM 1.56728183242116 0.071783668713536 no 303 0.0585244149942238 398 6254834 YHR062C RPP1
SGTC_271 rotenone 740 µM 1.56273085686267 0.0723681860356088 no 304 0.0590579566700702 427 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1780 st038448 24.544 µM 1.55936721085368 0.0728025440404604 no 305 0.0594547461597966 384 728868 YDL195W SEC31
SGTC_1412 3909-8563 178 µM 1.55660869053112 0.0731602476926834 no 306 0.0597817096101485 425 23767530
SGTC_2166 5933061 31.504 µM 1.55285426292051 0.0736492516215688 no 307 0.0602289778194281 400 2877375
SGTC_263 alizarin 107.927 µM 1.5523455006772 0.0737157083106364 no 308 0.060289788113649 487 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2054 5233173 129 µM 1.54921493157358 0.0741256458200574 no 309 0.0606650306161793 461 6889
SGTC_1645 Cervolide 78 µM 1.54864474736513 0.0742004966345415 no 310 0.0607335714130883 352 23173 A fragrance.
SGTC_2275 7947463 200 µM 1.54503042301266 0.0746763097142896 no 311 0.0611694523751978 365 1225414
SGTC_255 tunicamycin 200.472 nM 1.54326303932048 0.0749098255909123 no 312 0.0613834837628029 437 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1323 1348-1351 11.2 µM 1.54250425991608 0.0750102501913792 no 313 0.0614755517796216 364 6989654
SGTC_1620 st003704 16.5 µM 1.54233555433726 0.075032592353827 no 314 0.0614960366573461 364 2834414
SGTC_2594 a-mangostin 100 µM 1.54073974641333 0.0752441808881049 no 315 0.0616900695843385 433 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1283 0922-0125 16.4 µM 1.54008144279156 0.075331597927529 no 316 0.0617702512874239 435 3360884
SGTC_2198 6589944 200 µM 1.53733266780713 0.07569744818907 no 317 0.0621059327987729 305 5290268
SGTC_1461 k072-0203 53.8 µM 1.52921480009192 0.076785803536741 no 318 0.0631056013813206 382 5418714
SGTC_1857 st056007 79.3 µM 1.52842805658494 0.0768919107389844 no 319 0.0632031466246351 356 619834
SGTC_3294 9122953 26.2835 µM 1.52825680092952 0.0769150225598198 no 320 0.0632243954938294 405 16459826
SGTC_2134 5324836 1.464 µM 1.52526019630924 0.077320284676869 no 321 0.0635971057563395 328 699272
SGTC_1579 chlormadinone acetate 49.4 µM 1.52506740163474 0.0773464137438879 no 322 0.0636211434921715 411 45114258 A steroidal progestin.
SGTC_41 0478-0632 82.643 µM 1.52465503511099 0.0774023234476869 no 323 0.0636725812856093 478 3750424
SGTC_1672 st016598 6.51 µM 1.52316465046826 0.0776046495623967 no 324 0.0638587587818999 436 4665860 YNL267W PIK1
SGTC_40 0327-0103 19.753 µM 1.52294120080791 0.077635018396108 no 325 0.0638867083715454 405 409036
SGTC_1228 0124-0032 52.5 µM 1.52132073235896 0.0778555247768851 no 326 0.0640896849963382 432 X1228
SGTC_823 0417-1665 178 µM 1.51886352024033 0.0781907980168233 no 327 0.0643984265285336 410 3429856
SGTC_1236 0330-0013 258 µM 1.51823589427562 0.0782766094928671 no 328 0.0644774708932056 369 4617066
SGTC_2344 7990960 76.95 µM 1.51810369439127 0.0782946934805395 no 329 0.0644941299956114 388 140813
SGTC_1655 st012546 55.1 µM 1.51569165780265 0.0786251991333772 no 330 0.0647986690174384 377 720985 YLR208W SEC13
SGTC_1704 st028805 70.8 µM 1.5144597596691 0.0787944055148743 no 331 0.0649546362291739 393 2876101
SGTC_2366 9070441 60.58 µM 1.51044351560408 0.0793479697140247 no 332 0.0654651460048875 429 6837235
SGTC_1888 azatryptophan 97.5 µM 1.5102969475073 0.0793682269213334 no 333 0.0654838351427976 360 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2310 7668677 200 µM 1.50805447466952 0.0796786478647134 no 334 0.0657702927485913 421 2197143
SGTC_2138 5575593 77.673 µM 1.50644013818029 0.0799026851623554 no 335 0.0659771116819049 341 762213
SGTC_762 1165-0429 115 µM 1.50536616502212 0.080051994610417 no 336 0.0661149814677793 417 5967793
SGTC_3296 9122258 64.045 µM 1.50406715094096 0.0802328721930207 no 337 0.0662820386733165 433 4730474
SGTC_1979 st071809 45.3 µM 1.50321878872965 0.0803511666443025 no 338 0.0663913170012354 406 4976333
SGTC_1023 4482-3888 16 µM 1.50247353579878 0.0804551923769626 no 339 0.0664874287791583 395 3303168
SGTC_3173 9105693 49.47 µM 1.50048738691026 0.0807329247994557 no 340 0.0667440991597484 442 17096658
SGTC_174 3553-0389 74.3 µM 1.49909462802327 0.080928112160818 no 341 0.0669245425145146 374 738071
SGTC_85 0868-0259 160.055 µM 1.49402179709767 0.0816420532444108 no 342 0.0675849611056398 385 83173
SGTC_2664 lyso-paf C-16 73.48 µM 1.4921093347106 0.0819124388296716 no 343 0.0678352425746794 440 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2748 diazoxide 86.69 µM 1.4882372326931 0.0824619453962702 no 344 0.0683441707092563 354 3019 A potassium channel activatior.
SGTC_65 0798-0905 34.986 µM 1.48204578168525 0.083346360731757 no 345 0.0691640568633418 557 3602145
SGTC_311 1315-0136 58 µM 1.47499034465541 0.0843628625387592 no 346 0.0701075696373371 423 6759207
SGTC_2000 st075254 36.4 µM 1.47156755588472 0.0848593344538515 no 347 0.07056884608524 386 17234175
SGTC_470 aa-861 153 µM 1.46824890482744 0.0853427897516284 no 348 0.071018312245435 490 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_788 1182-0090 188 µM 1.46814139972844 0.0853584853373844 no 349 0.0710329090296291 573 5715185
SGTC_916 4466-0038 42 nM 1.46792921262987 0.0853894706861534 no 350 0.0710617260461695 571 5722064 YGL116W CDC20
SGTC_473 2-arachidonoylglycerol 10 µM 1.46229784513461 0.0862148923989795 no 351 0.0718298043926081 435 5282280 An endocannabinoid.
SGTC_876 0720-0963 56.8 µM 1.46034513504365 0.0865025014187987 no 352 0.0720976216507763 474 765861
SGTC_969 1313-0238 134 µM 1.46028287855767 0.0865116827810603 no 353 0.0721061728000347 499 5212874
SGTC_686 1319-0111 510 µM 1.4601912849158 0.0865251920057327 no 354 0.07211875492505 470 4562600
SGTC_658 3253-0951 102 µM 1.45907577250632 0.0866898464671383 no 355 0.0722721268179664 561 1184878
SGTC_1387 3342-1166 1.8 µM 1.45732369310545 0.0869489335476094 no 356 0.0725135248052842 347 3418228
SGTC_2982 9019404 25.97 µM 1.44915527072107 0.0881644696733118 no 357 0.0736471128394602 388 22333232
SGTC_2568 diosmetin 100 µM 1.44856737115345 0.0882524407420447 no 358 0.0737292194103873 479 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2179 6298986 200 µM 1.44529201271651 0.088743750905906 no 359 0.0741879402247422 410 738374
SGTC_3031 9088762 49.47 µM 1.4428903262975 0.0891053008702181 no 360 0.0745256843283729 456 205253
SGTC_1214 0358-0031 63.7 µM 1.44239842916899 0.0891794861481167 no 361 0.0745950033730655 462 4301366
SGTC_610 4215-0184 155 µM 1.43867781176582 0.0897420987662648 no 362 0.0751209143488004 482 5605015
SGTC_486 niguldipine 82 µM 1.43664121427792 0.0900511778775062 no 363 0.0754099832319588 388 1236 A calcium channel blocker.
SGTC_2428 5615643 7.78 µM 1.43380142567884 0.0904834706225242 no 364 0.0758144690177578 459 2253075
SGTC_2878 9043973 25.97 µM 1.4320602948252 0.0907492787346736 no 365 0.0760632831775768 424 6465167
SGTC_1373 2887-0003 58.5 µM 1.43177142484418 0.0907934347878256 no 366 0.076104623842973 453 776948
SGTC_676 falcarinol 140 µM 1.43093960316035 0.0909206743388385 no 367 0.0762237627726991 485 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_940 3232-1287 54.8 µM 1.42933025631682 0.0911672234568753 no 368 0.0764546668349648 464 1585493 YIL048W NEO1
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.42450318337217 0.0919096959035082 no 369 0.0771504321116774 545 91467 include heat shock
SGTC_962 1254-0300 21.5 µM 1.42389207708822 0.092004011186174 no 370 0.0772388578365528 458 7340576
SGTC_1829 berberine 14.4 µM 1.42364383374523 0.0920423443640444 no 371 0.0772748000821348 454 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1075 aripiprazole 15.2 µM 1.42357139810818 0.092053531940438 no 372 0.0772852901673683 534 60795 An atypical antipschotic. YIL048W NEO1
SGTC_625 k213-0058 121 µM 1.41729767671913 0.0930263230160003 no 373 0.0781979570727065 652 3655420
SGTC_1878 temozolomide 1 mM 1.41718460032712 0.0930439258688676 no 374 0.0782144814858317 430 5394 DNA alkylating agent.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.41399895440786 0.0935408546586909 no 375 0.0786811047415085 428 688803
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.41393939135534 0.0935501645268445 no 376 0.0786898493952589 464 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1980 st071811 45.7 µM 1.41094047861276 0.0940197877737357 no 377 0.0791310826409826 457 4974850
SGTC_389 tpck 16.7 µM 1.40889361054342 0.0943413202789392 no 378 0.0794333145809667 458 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_592 k241-0073 46.5 µM 1.40731746144142 0.0945894619372447 no 379 0.0796666369002265 492 4230158
SGTC_2436 5633522 8.09 µM 1.40677084582248 0.0946756308484357 no 380 0.0797476751045399 503 5724242
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.40627282336206 0.0947541898544689 no 381 0.0798215634285684 557 688664
SGTC_2005 4024620 188 µM 1.39809491480382 0.0960510671891338 no 382 0.0810422833668574 460 236743
SGTC_1011 4112-3381 17.4 µM 1.39569261872531 0.0964344992586969 no 383 0.081403539008427 485 2877139
SGTC_2411 st077133 39.94 µM 1.39520219584537 0.0965129140301082 no 384 0.0814774375270641 562 1403142 YNL221C POP1
SGTC_1349 flufenamic acid 69 µM 1.39009496881042 0.0973323052351139 no 385 0.0822500204388615 460 3371 A non-steroidal anti-inflammatory.
SGTC_664 1222-0054 14.9 µM 1.3864804699552 0.0979152831620644 no 386 0.0828001198841114 493 6813991
SGTC_2452 5863136 48.41 µM 1.38424123669089 0.0982777277166737 no 387 0.0831423002916559 484 2184096
SGTC_1332 1480-0653 17.5 µM 1.38318128388754 0.0984496350056471 no 388 0.0833046435130533 499 5749438
SGTC_2469 5655019 90.81 µM 1.38093692735359 0.0988143599984264 no 389 0.0836491772822121 498 2788239
SGTC_1118 chelidonine 707.474 nM 1.37911372496861 0.0991113713087108 no 390 0.0839298463912881 538 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2566 crystal violet carbinol 226 nM 1.37813299836213 0.0992714077527894 no 391 0.0840811145350298 455 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_868 0527-0199 213 µM 1.37745213453936 0.0993826232020486 no 392 0.0841862518887171 520 2849450
SGTC_1786 berberine 21.6 µM 1.37370820800833 0.0999958012407733 no 393 0.0847661438417835 508 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_348 k064-0012 10.7 µM 1.37367396510329 0.100001422244238 no 394 0.0847714614693472 460 5066323
SGTC_2229 7354935 190 µM 1.37345498531002 0.100037373428697 no 395 0.0848054730557186 419 318112
SGTC_526 4469-0568 170 µM 1.37003409740328 0.10060022625358 no 396 0.0853381290339453 491 2901964
SGTC_874 0599-0792 117 µM 1.36999435596453 0.10060677862359 no 397 0.0853443317447114 579 765305
SGTC_748 act1.228 77.9 µM 1.36907093211331 0.100759115804986 no 398 0.0854885517583235 562 4421505 YNR035C ARC35
SGTC_856 0433-0016 11.3 µM 1.36773366715048 0.100980022421141 no 399 0.085697728770055 532 3911780
SGTC_716 1683-5115 658 µM 1.3673450284044 0.101044288929884 no 400 0.0857585920342333 567 723597
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.36659886824357 0.101167759845625 no 401 0.085875536082813 546 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3112 9123419 49.47 µM 1.36450762031617 0.101514395103777 no 402 0.086203928751867 536 17015854
SGTC_2204 7233102 200 µM 1.36371526810787 0.101645957321046 no 403 0.086328598406189 426 2172480
SGTC_1926 methyl fluorone black 53.6 µM 1.35788553024452 0.10261774599152 no 404 0.0872500047382574 466 72721 Reacts with homocysteine.
SGTC_1524 corynanthine 62.1 µM 1.35354887779859 0.103345012751133 no 405 0.0879401730917779 482 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_415 dibenzyl ketone 100 µM 1.35224637468349 0.103564174528066 no 406 0.0881482564369114 507 7593
SGTC_3087 9117406 49.47 µM 1.35117613106648 0.103744508131078 no 407 0.0883195093404014 487 42546093
SGTC_1218 1348-1416 30.7 µM 1.3488059528529 0.104144688386413 no 408 0.0886996510790189 520 6787668
SGTC_1424 4048-1941 275 µM 1.34794996137224 0.104289488462997 no 409 0.0888372386174614 541 X1424
SGTC_2837 9008476 45.46 µM 1.3420998998734 0.105282996215134 no 410 0.0897818031803824 544 2992805
SGTC_3228 9131799 49.47 µM 1.34120804557364 0.105435058129877 no 411 0.0899264574546784 507 17015818
SGTC_89 0302-0250 142.109 µM 1.34037119926382 0.105577885539436 no 412 0.0900623471533687 563 4203518 YLR208W SEC13
SGTC_1962 st076595 64.5 µM 1.34028858659862 0.105591992908419 no 413 0.0900757703238831 519 279619
SGTC_996 3970-0799 1.8 µM 1.33836051359237 0.105921627923459 no 414 0.0903894721088641 689 6615648 YGL040C HEM2
SGTC_500 h-89 112 µM 1.33825809882424 0.105939158148533 no 415 0.0904061578826929 557 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2763 lisinopril 49.32 µM 1.33728380392789 0.106106032008912 no 416 0.090565007819833 472 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_895 0964-0006 13.7 µM 1.33689803432549 0.10617215774693 no 417 0.0906279612793115 509 6738897
SGTC_3097 9117246 49.47 µM 1.33384042169513 0.106697324066974 no 418 0.0911280802385568 512 16423892
SGTC_1914 st062367 72.6 µM 1.33167724457974 0.107069995487629 no 419 0.0914831349417936 500 978205
SGTC_3012 9080433 71.4286 µM 1.3297545429055 0.10740202514536 no 420 0.0917995787828903 542 17688859
SGTC_569 4130-2812 160 µM 1.32641329481988 0.107980786670156 no 421 0.0923514187385399 403 743552
SGTC_3152 9099253 49.47 µM 1.32521803713963 0.108188370223247 no 422 0.0925494222954953 639 25236131
SGTC_101 0490-5701 117.494 µM 1.32301603802808 0.108571548969199 no 423 0.0929150221962717 475 4661669
SGTC_3010 9080089 71.4286 µM 1.32195863264754 0.108755898894527 no 424 0.0930909631692312 519 17027233
SGTC_1605 st000082 49.1 µM 1.3193153454174 0.109217718624195 no 425 0.0935318548570881 510 1114022
SGTC_1796 st049173 110.4 µM 1.31751358776599 0.109533317724503 no 426 0.093833264763682 460 94134
SGTC_814 3342-0569 96 µM 1.31714044081718 0.109598760589849 no 427 0.0938957767641905 569 4346283
SGTC_3353 9151644 39.2805 µM 1.31561520889811 0.10986654911055 no 428 0.0941516131198817 548 4909158
SGTC_452 diindolylmethane 8 µM 1.31521944759703 0.109936110510551 no 429 0.0942180805032914 464 3071 Inhibits expression of several cancer promoting factors.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.31252140379112 0.110411177268591 no 430 0.0946721345390234 451 77254
SGTC_453 enantio-paf c16 10 µM 1.31103346661394 0.110673799441842 no 431 0.0949232285735186 715 13871343 A lipid and platelet activating factor
SGTC_1834 st055981 52.8 µM 1.3051497548123 0.1117166641291 no 432 0.0959209297030029 545 471719 YDL150W RPC53
SGTC_1684 st024538 14.6195 µM 1.30309369590227 0.112082744663502 no 433 0.0962713877946043 534 6732859
SGTC_1422 4031-0024 15.5 µM 1.30244268705767 0.112198835103109 no 434 0.0963825490865301 535 782427
SGTC_183 3914-0051 30.55 µM 1.3022583294508 0.112231726080547 no 435 0.0964140457126139 539 1596232
SGTC_3034 9090421 49.47 µM 1.30186377769322 0.112302140649819 no 436 0.0964814784290547 485 17173761
SGTC_1938 st074717 56.4 µM 1.30171227603178 0.112329187122261 no 437 0.09650738073573 481 17250979
SGTC_2278 7948257 134.34 µM 1.2998314757143 0.112665340123456 no 438 0.0968293675187831 542 1247028
SGTC_2602 kawain 100 µM 1.29859481958355 0.112886757171998 no 439 0.0970415083720825 605 5369129
SGTC_2653 dihydrofissinolide 100 µM 1.29580535976734 0.113387336031221 no 440 0.097521275527644 508 6857746
SGTC_2216 7189485 200 µM 1.29535707315661 0.113467930146476 no 441 0.0975985395881468 534 731273
SGTC_2846 9008642 19.48 µM 1.28348880573194 0.115616511793511 no 442 0.0996604394744099 500 2992898
SGTC_1117 retinoic acid 1.10837 µM 1.2804250898756 0.116175817423384 no 443 0.100197837327295 606 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2519 cryptotanshinone 88.04 µM 1.27877920502006 0.11647707839406 no 444 0.100487409375014 540 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1985 st071382 65.5 µM 1.27875500864688 0.116481511400974 no 445 0.100491670961748 553 6123237
SGTC_753 1322-0200 289 µM 1.27742694580119 0.116725008778542 no 446 0.100725778340299 557 5403907
SGTC_3245 9134821 49.47 µM 1.27407017613098 0.117342073307263 no 447 0.101319273434921 570 17014901
SGTC_1466 k213-0079 57.5 µM 1.2727632601894 0.117582943334387 no 448 0.101551030998226 577 3657981
SGTC_2351 9026858 72.31 µM 1.2724423449942 0.117642142823541 no 449 0.101607998412314 519 1409300
SGTC_779 1360-0071 233 µM 1.26910284882625 0.118259434692133 no 450 0.102202192184906 612 7566
SGTC_1319 1306-0155 43.7 µM 1.26885838562259 0.1183047124842 no 451 0.10224578840128 624 3122360
SGTC_331 k048-0133 24.5 µM 1.26750994124286 0.118554682323166 no 452 0.10248650561859 508 6813582
SGTC_2356 9061756 188.97 µM 1.26745057618168 0.118565695779044 no 453 0.102497112619235 524 20104043
SGTC_1369 1866-0067 208 µM 1.26611758243633 0.118813184298854 no 454 0.102735494323354 632 3531355
SGTC_3220 9131269 49.47 µM 1.26539126308613 0.118948188896393 no 455 0.102865552796802 542 17722206
SGTC_1146 3579-1023 7 µM 1.26529171983976 0.118966699933121 no 456 0.102883386838907 629 X1146
SGTC_1927 st060202 13.8 µM 1.26388734431377 0.119228074067215 no 457 0.103135232436357 555 688887
SGTC_3043 9092303 49.47 µM 1.26072787778206 0.119817576402134 no 458 0.103703453156141 520 25236084
SGTC_1303 1160-0052 261 µM 1.25979507964641 0.119992012834316 no 459 0.10387164761575 573 3562476
SGTC_3011 9081274 71.4286 µM 1.25916100064739 0.120110689917301 no 460 0.103986092410021 619 6625322
SGTC_3021 9087658 49.47 µM 1.25825796486055 0.120279848913053 no 461 0.104149238962095 521 25237042
SGTC_1307 1187-1599 12.2 µM 1.25815146219794 0.120299810325836 no 462 0.104168492443612 573 1538471
SGTC_1141 3253-0389 52.6 µM 1.25599896469779 0.120703745523334 no 463 0.104558172723446 553 5402031
SGTC_2723 salbutamol 83.58 µM 1.2530314435055 0.12126219120871 no 464 0.105097131855693 472 9884233 β2-adrenoceptor agonist
SGTC_1515 3460-0031 42.1 µM 1.2521378300794 0.121430712066205 no 465 0.105259822518235 496 2876596
SGTC_2289 7946404 165.07 µM 1.24761615270468 0.122285950584346 no 466 0.106085830142238 669 1246120 YPR165W RHO1
SGTC_3104 9120930 49.47 µM 1.24493031950759 0.122795951231238 no 467 0.106578682384581 515 17014836
SGTC_1499 4480-0877 67.3 µM 1.2411023286134 0.123525406147862 no 468 0.107283974723854 544 2861909
SGTC_2398 5228213 48.84 µM 1.24108101781266 0.123529475571869 no 469 0.107287910551611 681 80771 YMR134W ERG29
SGTC_1092 toremifene 6.32 µM 1.23963496246993 0.123805827808008 no 470 0.107555221402522 644 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_694 1315-0438 43.2 µM 1.2394826396191 0.123834963045309 no 471 0.107583406989398 498 6793154
SGTC_417 st075190 100 µM 1.23837590604785 0.124046795334465 no 472 0.107788355104476 618 222757
SGTC_2047 4141938 200 µM 1.23143210719987 0.125381646318688 no 473 0.10908064735245 536 3807862
SGTC_211 3455-0679 143.504 µM 1.22918725452933 0.125815325687383 no 474 0.109500803235132 618 748649
SGTC_1257 0669-0121 16 µM 1.22076908757898 0.127450930800056 no 475 0.111086730541759 662 4307855
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.21863534513658 0.127867844165596 no 476 0.111491313799131 589 616764
SGTC_808 0711-0032 135 µM 1.21518257674353 0.128544488636113 no 477 0.112148232072483 598 4252555
SGTC_3056 9094900 49.47 µM 1.21445270109008 0.128687841122255 no 478 0.112287450582224 581 25236784
SGTC_3305 9127027 53.8275 µM 1.21292731420889 0.128987795422362 no 479 0.112578805783212 609 41905295
SGTC_2560 caryophyllene 100 µM 1.21232028460197 0.129107297367839 no 480 0.112694901012943 646 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2927 9011802 47.9 µM 1.21153528895629 0.12926194810791 no 481 0.11284515921623 586 43912568
SGTC_1990 st072050 59.8 µM 1.21102797541762 0.129361961416583 no 482 0.112942341565926 626 17233948
SGTC_1505 k297-0037 20.6 µM 1.20527421712445 0.130500028302342 no 483 0.114048729750995 628 4089396
SGTC_2871 9038510 12.99 µM 1.20524758839768 0.130505311388235 no 484 0.11405386806562 663 4945164
SGTC_2342 7990637 118.86 µM 1.20299447044015 0.130952861257872 no 485 0.1144892301793 637 2033102 YER133W GLC7
SGTC_3151 9099821 49.47 µM 1.20095078275389 0.131359727048122 no 486 0.114885146782432 581 17174189
SGTC_204 PMA1.184 62.41 µM 1.197764256038 0.131995853882148 no 487 0.115504403069751 667 2252213 YGL008C PMA1
SGTC_977 1348-1378 135 µM 1.19709815757135 0.132129095245742 no 488 0.115634149010288 640 X977
SGTC_2184 6075246 200 µM 1.19682035356024 0.13218469248031 no 489 0.115688291626575 625 2267320
SGTC_141 0443-0274 32.331 µM 1.19446140402842 0.1326574417056 no 490 0.116148764844888 738 1627241
SGTC_1120 ficusin 1.78878 µM 1.19411030226128 0.13272790429008 no 491 0.116217411900113 640 6199 A DNA cross-linker.
SGTC_2291 7917025 104.35 µM 1.19292540824433 0.132965890840949 no 492 0.116449293679136 641 2964612
SGTC_1673 st016611 27.3 µM 1.19272575732061 0.133006019729952 no 493 0.116488397316593 638 5226799
SGTC_51 1013-0126 23.419 µM 1.19071145501923 0.133411351321809 no 494 0.116883439708999 599 1627850
SGTC_677 0929-0063 136 µM 1.19034367872538 0.133485449400783 no 495 0.116955669919155 555 1539583
SGTC_153 4077-0274 519.67 µM 1.1850962222337 0.13454576925588 no 496 0.117989702286898 586 3121976
SGTC_3177 9107506 49.47 µM 1.18499755004212 0.134565762536473 no 497 0.118009207788624 586 8897194
SGTC_1038 k292-0204 154 µM 1.18186204678077 0.135202150587848 no 498 0.118630221745856 594 4454212
SGTC_2972 9093619 59.92 µM 1.18070248908557 0.135438018551506 no 499 0.11886046618071 617 25236256
SGTC_1263 0774-1208 64.8 µM 1.17505008463815 0.136591822039133 no 500 0.119987339394051 726 906585
SGTC_2154 5570129 200 µM 1.17036265322773 0.137553733727268 no 501 0.12092752916059 677 673366
SGTC_2585 alliin 100 µM 1.16907498742322 0.137818784350184 no 502 0.121186710206738 662 87310 A garlic compound which reacts with lipids.
SGTC_111 0083-0039 52.457 µM 1.16863353322037 0.137909732581032 no 503 0.121275655865958 502 759313
SGTC_1081 sertraline 6 µM 1.16843072968114 0.137951527812626 no 504 0.12131653278265 677 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1360 1598-0022 39.8 µM 1.16597564407538 0.138458175160291 no 505 0.121812146500008 733 761525
SGTC_1429 4049-0205 9.46 µM 1.16498975751301 0.138661985490278 no 506 0.122011569424456 705 22774478
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.16478506518673 0.138704326727719 no 507 0.122053002858113 689 676296 Flavone; oxidizing agent.
SGTC_2397 5161689 200 µM 1.16337558795526 0.138996120529266 no 508 0.122338574847601 672 2259942
SGTC_2082 5219693 150 µM 1.1606510433482 0.139561347101336 no 509 0.122891919295318 659 2834649
SGTC_1556 plumbagin 1.48 µM 1.15975862628879 0.139746824885921 no 510 0.123073546711987 578 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_20 0481-0013 4.944 µM 1.15879232261402 0.139947847972025 no 511 0.123270423839368 634 182045
SGTC_2218 6965428 192.983 µM 1.15834858102993 0.140040226689827 no 512 0.123360906758938 650 675684
SGTC_302 1094-0063 18.9 µM 1.15646190816505 0.140433459287958 no 513 0.123746135863793 581 5440289
SGTC_985 1493-0307 8.71 µM 1.15543783221698 0.140647217457551 no 514 0.12395558845131 600 3278274
SGTC_3283 9109332 35.8195 µM 1.15322202945499 0.141110483506052 no 515 0.124409631846586 557 17027281
SGTC_679 0422-0091 41.4 µM 1.14556272419864 0.142719806310494 no 516 0.125988064109474 695 627384 YHR062C RPP1
SGTC_1799 st045822 46.1415 µM 1.14422092879829 0.143003007779621 no 517 0.126266012844436 657 3674992
SGTC_350 k064-0020 19.8 µM 1.14049525140526 0.143791345000913 no 518 0.127040014958496 723 2790705
SGTC_1852 st056254 31.4 µM 1.13781546620333 0.144360185639312 no 519 0.12759877270615 653 442583
SGTC_2023 5144124 124 µM 1.13701440027905 0.144530522742409 no 520 0.127766132902757 669 2830192
SGTC_2401 5128683 200 µM 1.13561431966971 0.14482855821571 no 521 0.128059006591692 611 708373
SGTC_3050 9093513 49.47 µM 1.13402147544274 0.145168130218254 no 522 0.128392769934071 671 25236664
SGTC_3231 9132313 49.47 µM 1.13279166861768 0.145430673989846 no 523 0.128650875491666 685 4905967
SGTC_2842 9000675 19.48 µM 1.13112206792189 0.145787617418557 no 524 0.129001858599389 623 2989072
SGTC_1700 st030840 7.9285 µM 1.13057143454672 0.145905466180037 no 525 0.129117758105592 723 5499307
SGTC_133 0724-0033 378.92 µM 1.13010558874125 0.146005218343054 no 526 0.129215867544943 636 280309
SGTC_492 tmb-8 126 µM 1.12886774238601 0.146270502576156 no 527 0.129476815180949 506 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.12840691272673 0.146369346125368 no 528 0.129574054858429 678 229346 A bile salt which induces apoptosis.
SGTC_3008 9078912 71.4286 µM 1.12769873490076 0.146521330882431 no 529 0.129723586065593 662 16648731
SGTC_978 1416-0512 87.4 µM 1.12517358743504 0.147064124464511 no 530 0.130257741604496 718 6814003
SGTC_2208 7283366 200 µM 1.12154203552469 0.147847106487344 no 531 0.131028604540797 707 898663
SGTC_246 cycloheximide 667 µM 1.12148845039756 0.147858680583987 no 532 0.131040002505418 598 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_91 0417-1751 58.384 µM 1.11321999397119 0.149651892383387 no 533 0.132806978821811 802 6795624
SGTC_2713 st079149 53.4 µM 1.11200656431507 0.149916269423331 no 534 0.133067663978423 726 3103253
SGTC_440 fluspirilene 35.1 µM 1.10874745736137 0.150627891076673 no 535 0.133769571397055 708 3396 An atypical antipsychotic.
SGTC_378 3970-0959 8.33 µM 1.10804963448927 0.150780551695577 no 536 0.133920190342736 700 6615653
SGTC_1049 3226-0134 66 µM 1.10760563588119 0.150877737543773 no 537 0.134016084193788 742 5702385
SGTC_3141 9094609 49.47 µM 1.10633431440404 0.151156244803154 no 538 0.134290922347017 654 25236309 YDL196W YDL196W
SGTC_553 k007-0256 45.7 µM 1.10531427717684 0.151379950597862 no 539 0.134511716800225 711 6287000
SGTC_3355 9151058 44.0485 µM 1.10139495112383 0.152241550814414 no 540 0.13536240094028 691 17015728
SGTC_815 1582-0027 36.9 µM 1.10093263535454 0.152343397682497 no 541 0.135462988517166 708 3128206
SGTC_2115 tiliquinol 12.7705 µM 1.09889584346395 0.152792635650063 no 542 0.135906749940146 687 71208 A bioactive hydroxyquinoline.
SGTC_2666 tannic acid 100 µM 1.09807982340538 0.152972864552536 no 543 0.136084817432448 741 16134267 A thiamine antagonist.
SGTC_1410 3909-8106 77.9 µM 1.09748088489854 0.153105237754633 no 544 0.136215616138974 695 1039210
SGTC_2215 7188065 200 µM 1.09703614038779 0.153203581182847 no 545 0.13631279695547 677 940217
SGTC_2988 9073640 71.4286 µM 1.09690224432002 0.153233196936157 no 546 0.136342063781226 660 9102229
SGTC_1753 st043925 64 µM 1.09675420007453 0.153265946464838 no 547 0.136374428101101 722 670181
SGTC_217 ketoconazole 989 nM 1.09669556338104 0.153278919031796 no 548 0.136387248267141 703 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1838 st055369 84.5 µM 1.09415095971122 0.153842578644067 no 549 0.136944387761724 668 676036
SGTC_3232 9132874 49.47 µM 1.09403434366164 0.153868443304044 no 550 0.136969957997566 676 3784940
SGTC_1087 pterostilbene 9.05 µM 1.09037057310401 0.154682508636542 no 551 0.13777496950538 745 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1342 1486-1464 234 µM 1.09020910972982 0.154718450074299 no 552 0.137810520702488 741 3253938
SGTC_2446 5162541 200 µM 1.08644485267094 0.155557930278046 no 553 0.138641113416447 681 1549321
SGTC_2035 5154463 94.595 µM 1.08043838593638 0.156903664556347 no 554 0.139973505032333 742 2769623
SGTC_1923 st058458 19.1 µM 1.07943009686591 0.157130317864753 no 555 0.140198020067054 776 3534982
SGTC_2304 7443016 91.4 µM 1.0792365390624 0.157173852346984 no 556 0.140241147420886 665 939854
SGTC_2628 lathosterol 100 µM 1.07897830320195 0.15723194638643 no 557 0.140298699968912 721 6710616
SGTC_2467 5474540 200 µM 1.0766521672471 0.157755881940883 no 558 0.140817844562144 714 5413519
SGTC_135 0933-0004 26.348 µM 1.07220662894239 0.158760375047933 no 559 0.141813616817568 683 21230617 YGL099W LSG1
SGTC_503 tyrphostin 8 294 µM 1.06874005346385 0.159546569461883 no 560 0.142593408994686 723 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1794 st048918 76.9 µM 1.06856037152475 0.159587389382264 no 561 0.142633906610824 653 672303
SGTC_3249 9135183 49.47 µM 1.0679211957619 0.159732651939675 no 562 0.142778030282067 755 4902779
SGTC_1252 0493-0875 34.8 µM 1.06674079239689 0.160001144162359 no 563 0.143044450610374 702 3960963
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.06322219948469 0.160803226373433 no 564 0.143840598683842 768 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1657 st012939 43.4 µM 1.06227791756439 0.161018926560726 no 565 0.144054768105996 699 24207257
SGTC_668 1682-0499 62.6 µM 1.06137268666211 0.161225883609693 no 566 0.144260282286582 784 682214
SGTC_1844 rapamycin 4 nM 1.06121263146 0.161262494034353 no 567 0.144296640101864 818 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2841 9004761 38.96 µM 1.06077794540574 0.161361949847918 no 568 0.144395413668317 656 2991039
SGTC_1521 st012942 49.4 µM 1.06074291456018 0.161369966618191 no 569 0.144403375699148 795 24207259
SGTC_556 4058-0063 51.5 µM 1.05856879790516 0.161868019120819 no 570 0.144898101637612 799 6615692
SGTC_405 ebelactone b 50 µM 1.05707240525845 0.162211398054405 no 571 0.145239271967533 764 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2007 4011539 71.82 µM 1.05558204356792 0.162553864122 no 572 0.145579604096191 738 45595301
SGTC_1832 st054113 55 µM 1.05536600018955 0.162603547141097 no 573 0.145628983231604 724 1251267
SGTC_269 exalamide 29 µM 1.05498401247706 0.162691416186148 no 574 0.145716318359414 723 3316 A derivative of salicylamide.
SGTC_1462 k081-0014 26.5 µM 1.05285041393068 0.163182778103599 no 575 0.146204777601525 582 3270634
SGTC_1015 4130-4525 82 µM 1.05129232045458 0.163542211405665 no 576 0.146562176535107 749 1363237
SGTC_502 l-744,832 89.3 µM 1.04872033529409 0.164136661146197 no 577 0.147153426077869 763 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_941 3237-0776 460 µM 1.04827531149625 0.164239659262408 no 578 0.147255890474041 726 760008
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.04815054767171 0.164268542629657 no 579 0.147284625271417 788 688751
SGTC_324 1315-0088 19.6 µM 1.04722475481569 0.164482970588327 no 580 0.147497965300819 665 6787421
SGTC_928 2764-0428 58.7 µM 1.04650844736881 0.164649002915691 no 581 0.147663173435037 797 662578
SGTC_2262 9014885 67.46 µM 1.04614440947215 0.164733424570806 no 582 0.147747182099662 695 6457424
SGTC_1359 1582-0056 520 nM 1.04557325168497 0.164865934552094 no 583 0.147879052104781 811 3661189
SGTC_471 1-acyl-paf 4 µM 1.04548458813639 0.164886510897119 no 584 0.147899529978217 742 16759367
SGTC_2338 7999974 200 µM 1.0444189221427 0.165133952471369 no 585 0.148145806410805 828 315925
SGTC_2675 theaflavin digallate 100 µM 1.04299957291837 0.16546389034864 no 586 0.14847424528018 779 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3081 9117243 49.47 µM 1.03963172272455 0.166248476363422 no 587 0.149255516422269 760 45595589
SGTC_1928 4'-methoxychalcone 40.3 µM 1.03874850590444 0.166454630658066 no 588 0.149460857859762 796 641818
SGTC_2242 6630449 61.2675 µM 1.03732066080997 0.166788257198155 no 589 0.149793220025496 659 691249 YDR170C SEC7
SGTC_1407 3909-7909 12.3 µM 1.03710653774136 0.166838325806959 no 590 0.149843104328209 802 4411780
SGTC_482 fipronil 114 µM 1.03701677699772 0.166859317534352 no 591 0.149864019205812 729 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3143 9086658 49.47 µM 1.03669075099224 0.166935577324829 no 592 0.149940001911129 841 25236626
SGTC_3205 9113483 49.47 µM 1.035747502989 0.167156336288174 no 593 0.150159977300127 775 17018033
SGTC_1790 st045711 43.5 µM 1.03538017594416 0.167242356872692 no 594 0.150245700012813 753 585119
SGTC_745 0469-0705 296 µM 1.03536038657334 0.16724699195405 no 595 0.150250319162433 869 3486736
SGTC_2916 7875993 68.79 µM 1.03288592107708 0.1678272155758 no 596 0.150828644065304 769 1299250
SGTC_3134 9127454 49.47 µM 1.03097256213596 0.168276755858729 no 597 0.151276843401923 795 24262820
SGTC_826 1683-5028 118 µM 1.03008287630927 0.168486049529121 no 598 0.151485551408101 762 722377
SGTC_1364 1653-0028 37.6 µM 1.02939385043834 0.168648254008658 no 599 0.151647318846489 771 5718652
SGTC_1174 0739-0097 51.1 µM 1.028574759079 0.168841207909452 no 600 0.151839771996245 775 728447
SGTC_275 trichlorophene 5.69 µM 1.02843684876157 0.168873709481425 no 601 0.151872191265391 893 62616
SGTC_568 1193-0097 7.48 µM 1.02482757328533 0.169725742845413 no 602 0.152722276805477 782 3646150
SGTC_372 0155-0182 15.9 µM 1.02274401524696 0.170218856602309 no 603 0.153214447258584 826 771486
SGTC_2228 7354201 200 µM 1.02261264938568 0.170249977571055 no 604 0.153245513204909 793 753451
SGTC_1608 st001473 40.5 µM 1.0211259803037 0.170602427998725 no 605 0.153597377791203 744 7292267
SGTC_1559 coumarin 343 70.1 µM 1.01442894959669 0.172195905638496 no 606 0.155189058169482 748 108770 A hepatotoxic, DNA x-linker.
SGTC_1600 coumarin 106 71.1 µM 1.01398368135383 0.172302187519893 no 607 0.155295269536309 820 100336 A hepatotoxic, DNA x-linker.
SGTC_910 3454-3003 490 µM 1.0079978941007 0.173735007194482 no 608 0.156727736606103 812 820824
SGTC_1569 carminic acid 40.6 µM 1.00688181968125 0.174002998257724 no 609 0.156995784791272 822 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1353 1498-1206 8.11 µM 1.00661773536792 0.174066448442774 no 610 0.157059254155121 846 6756808
SGTC_2 0422-0095 29 µM 1.00481687766678 0.17449952335365 no 611 0.157492517681597 670 6790840
SGTC_3221 9128209 49.47 µM 1.00460662978382 0.174550128882238 no 612 0.157543151810969 760 16460723
SGTC_3341 9147222 25.867 µM 1.00290961511829 0.174958932291472 no 613 0.157952236496923 752 1939759
SGTC_1474 0330-0125 5.35 µM 1.0028216521677 0.174980138729739 no 614 0.157973459962515 811 X1474
SGTC_3350 9150499 3.57 µM 1.00008959375814 0.175639605481636 no 615 0.158633575836041 850 4910996 YPR165W RHO1
SGTC_550 4123-0385 25.7 µM 0.999119087739877 0.175874245697887 no 616 0.158868502794681 786 5731123
SGTC_2677 mitomycin C 100 µM 0.997293882284679 0.176316064939256 no 617 0.159310941179236 762 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2969 9091408 28.7 µM 0.996377818024352 0.176538076940782 no 618 0.159533303277395 760 4286311
SGTC_838 0109-0203 71.4 µM 0.995966372267819 0.17663785005347 no 619 0.159633242201228 816 759422
SGTC_200 k038-0079 37.545 µM 0.993439548969143 0.177251371104905 no 620 0.160247898134809 801 3436683
SGTC_2875 9039966 71.43 µM 0.990874609216535 0.177875521564677 no 621 0.160873405995439 802 6463691
SGTC_2104 5389443 200 µM 0.990445013662223 0.177980194380213 no 622 0.160978326423026 831 2244536
SGTC_3335 9143315 29.6265 µM 0.989251589027285 0.178271181228604 no 623 0.161270031690128 795 4899691
SGTC_558 k064-0027 21.3 µM 0.988961396815518 0.178341982654702 no 624 0.16134101460001 835 5088526
SGTC_247 mechlorethamine 29.705 µM 0.988490457251545 0.178456920727717 no 625 0.161456252853962 763 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1194 1488-0194 225 µM 0.986439485440394 0.178958027322113 no 626 0.161958748483086 832 1391452
SGTC_1554 st069299 38.7 µM 0.985761442185343 0.179123885768865 no 627 0.162125095403203 798 24207999
SGTC_2834 9001755 58.44 µM 0.985222289879945 0.179255838625028 no 628 0.162257447061568 741 2989575
SGTC_2948 9070189 9.45 µM 0.982906501700025 0.179823302659623 no 629 0.162826728805153 748 6473636 YDL196W YDL196W
SGTC_948 3448-0295 75.3 µM 0.981039851743671 0.180281529635899 no 630 0.163286544818169 852 678569
SGTC_1929 genistein trimethyl ether 50.5 µM 0.979967406606389 0.180545125603656 no 631 0.16355110381504 834 136420
SGTC_2926 9010726 65.15 µM 0.979386091523064 0.180688107837725 no 632 0.163694623344802 797 2994293
SGTC_1477 0139-0234 16 µM 0.978543907180935 0.180895380262974 no 633 0.16390269326011 838 620880
SGTC_2907 7721985 69.9 µM 0.977933195251688 0.181045777515217 no 634 0.164053682942865 805 3267881
SGTC_2570 licareol 100 µM 0.976325481275041 0.181442076380967 no 635 0.16445159823499 788 443158
SGTC_1219 1469-0211 33.1 µM 0.975625648464906 0.181614753539586 no 636 0.164625004774672 815 6822282
SGTC_3090 9117696 49.47 µM 0.972821674506308 0.18230763869324 no 637 0.165320969195622 827 7923821
SGTC_3267 9137951 49.47 µM 0.972803006496667 0.182312257241141 no 638 0.165325609086677 816 16643986
SGTC_2651 TUB2.036 5 µM 0.972205671844361 0.182460079064786 no 639 0.165474119730924 994 15992207 YFL037W TUB2
SGTC_2576 guaiol 23.12 µM 0.968657970730545 0.183339567301489 no 640 0.166357934563679 892 227829
SGTC_445 e6 berbamine 66 µM 0.968341056460586 0.183418259921844 no 641 0.166437033316549 917 6610268 A calcium/calmodulin antagonist.
SGTC_1376 2910-0861 41.3 µM 0.967365197364923 0.183660706597671 no 642 0.166680750832582 875 1112859
SGTC_1022 4477-0945 21.3 µM 0.967155520163843 0.183712825762929 no 643 0.166733147048649 815 4648966
SGTC_1487 3970-0795 2.82 µM 0.96378923141755 0.184550840514964 no 644 0.167575803323809 858 3765103
SGTC_1732 st034308 51.822 µM 0.963434977733047 0.18463916761175 no 645 0.167664640090334 794 830119
SGTC_903 1134-0042 114 µM 0.962987759106545 0.184750711457377 no 646 0.167776833131383 832 701009
SGTC_2676 harmalol 100 µM 0.962834834360377 0.184788863069677 no 647 0.167815208212869 872 5459187 A monoamine oxidase inhibitor
SGTC_1441 4106-0040 13 µM 0.961130356769948 0.185214426964766 no 648 0.168243313920217 850 2904180
SGTC_1870 st057514 26.5 µM 0.960424393347953 0.185390865849922 no 649 0.168420833038 824 5393161
SGTC_619 1652-1634 108 µM 0.959535161958643 0.1856132566703 no 650 0.168644607428614 796 5400454
SGTC_1702 st027038 51 µM 0.957937769189112 0.186013169472306 no 651 0.169047069843392 845 5521182
SGTC_489 paxilline 115 µM 0.95787249672693 0.186029522010736 no 652 0.169063528319014 788 105008 A toxic potassium channel blocker.
SGTC_2381 9035592 200 µM 0.957339670174968 0.186163042975814 no 653 0.169197919218418 775 4749657
SGTC_590 k048-0076 22.4 µM 0.957317148046473 0.186168688102319 no 654 0.169203601318743 843 6832814
SGTC_3187 9109394 49.47 µM 0.956611435655742 0.186345627244004 no 655 0.169381707324864 834 17098090
SGTC_1727 st034309 9.9045 µM 0.956578200750391 0.186353962605489 no 656 0.169390098036473 915 870305
SGTC_354 2783-3500 4.88 µM 0.955561073632492 0.186609171229214 no 657 0.169647017912221 816 6740761
SGTC_885 0865-0106 16.8 µM 0.954693430869419 0.186827043497935 no 658 0.169866376438324 838 2793380
SGTC_213 1246-0773 967 nM 0.952426697569229 0.187396981449823 no 659 0.170440312528258 872 6251622
SGTC_766 1391-0721 126 µM 0.951602077218803 0.187604586871345 no 660 0.170649413837212 869 1020919 YIL115C NUP159
SGTC_2261 9010538 184.68 µM 0.950985048414294 0.187760022204834 no 661 0.170805982938069 735 6457250
SGTC_2688 kanamycin b 96.69 µM 0.946532098041099 0.188884119044427 no 662 0.171938629348617 1179 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_382 3229-0966 23.2 µM 0.944480209365713 0.189403487744172 no 663 0.172462155224604 892 5722370
SGTC_2365 9042475 200 µM 0.943520292761385 0.189646760809162 no 664 0.172707420317107 839 6464479
SGTC_2872 9044037 25.97 µM 0.942756040991246 0.189840583618197 no 665 0.172902850645645 834 6465195
SGTC_703 3875-0075 71.8 µM 0.942415899674337 0.189926886420435 no 666 0.172989875040479 918 2850814
SGTC_1916 st067606 49.2 µM 0.940888908227851 0.190314621440045 no 667 0.173380896145101 904 19590279
SGTC_80 0159-0065 512.242 µM 0.940655885394303 0.19037383353542 no 668 0.17344061641918 794 1548079
SGTC_2443 5493264 126.67 µM 0.940223007024744 0.190483859802601 no 669 0.173551591433164 886 5340055
SGTC_3158 9100007 49.47 µM 0.939370479435903 0.190700663978134 no 670 0.173770282061456 797 19297233
SGTC_684 1140-0066 328 µM 0.937426583489433 0.191195577385585 no 671 0.174269585999287 887 6813534
SGTC_2325 6158266 200 µM 0.936605896155224 0.191404759512639 no 672 0.174480658978797 826 3623240
SGTC_2416 tofa 880 nM 0.936146354049226 0.191521951821501 no 673 0.174598919726612 779 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_633 0437-0093 97.7 µM 0.935057211900298 0.191799880075685 no 674 0.17487940795527 873 2831118
SGTC_2311 7694451 200 µM 0.933615796890081 0.192168081063651 no 675 0.175251056880823 852 2163142
SGTC_992 3909-8734 162 µM 0.932152413486866 0.192542335781834 no 676 0.17562888202668 853 4288319
SGTC_1418 3966-3099 2.4 µM 0.929410947195043 0.193244653435057 no 677 0.176338078325914 884 740335
SGTC_1334 1486-0610 236 µM 0.925721159815541 0.194192379687683 no 678 0.17729545423178 870 3742339
SGTC_2506 ethyl hematommate 54.16 µM 0.924096135762526 0.194610665408517 no 679 0.177718132520966 790 3940691 An allergen.
SGTC_2539 epi(13)torulosol 80 µM 0.923404405322806 0.194788884984127 no 680 0.177898248419504 851 6708597
SGTC_1716 st033144 30.6155 µM 0.923179589580132 0.194846828577851 no 681 0.177956811739119 919 674617
SGTC_542 3381-0244 89.3 µM 0.922206677672805 0.195097705916399 no 682 0.178210390303182 948 1112843
SGTC_2534 helenine 20.12 µM 0.920894726748503 0.195436319384798 no 683 0.17855269599418 835 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1464 k208-0027 110 µM 0.920001478510439 0.195667070157931 no 684 0.178785993300111 910 X1464
SGTC_1109 tnp00067 928.257 nM 0.919213155302022 0.195870853222118 no 685 0.178992045765532 876 676295
SGTC_2669 eugenol 100 µM 0.916818090397334 0.19649077167671 no 686 0.179618985674372 842 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_273 hydroxyurea 18.1 mM 0.915163690897278 0.196919675982929 no 687 0.180052851433153 967 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_404 fumagillin 50 µM 0.914478202198721 0.197097555388198 no 688 0.180232813266946 907 12015870 A methionine aminopeptidase binder.
SGTC_663 1486-0733 13.9 µM 0.913282714966601 0.197408008327312 no 689 0.180546935383831 905 722445 YPR165W RHO1
SGTC_2451 5856223 45.7 µM 0.912709346860918 0.197557009652361 no 690 0.180697713377905 864 2179896
SGTC_2282 7944268 200 µM 0.911952945794002 0.197753679778752 no 691 0.180896744090968 901 2970414
SGTC_2053 5265679 138 µM 0.909992835595733 0.198263873826144 no 692 0.18141314406569 894 764595
SGTC_338 4055-0136 114 µM 0.90779946663668 0.198835723378544 no 693 0.181992090120372 898 2900563
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.907218161789325 0.198987446204134 no 694 0.182145720664181 902 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3078 9116413 49.47 µM 0.906820828702305 0.199091191813907 no 695 0.182250776735721 891 17177322
SGTC_2695 st077686 51.995 µM 0.906404001562614 0.199200062433432 no 696 0.182361027785117 859 2876092
SGTC_632 0781-2353 4.65 µM 0.905641652569252 0.199399272266002 no 697 0.182562777365699 931 6811515 YHR007C ERG11
SGTC_2079 5212404 121 µM 0.905512585949688 0.199433010603024 no 698 0.182596947609772 943 758462
SGTC_5 0352-0601 109.883 µM 0.903068048702229 0.200072667487949 no 699 0.183244890170495 862 762456
SGTC_2932 9016711 44.54 µM 0.90176813314913 0.200413315348109 no 700 0.183590025579706 961 7117328
SGTC_1278 0874-0585 172 µM 0.898169511051026 0.201358163617029 no 701 0.184547592610367 914 766306
SGTC_2703 st077852 53.4 µM 0.89754348520603 0.201522804148042 no 702 0.184714490130841 878 6281836
SGTC_1720 st037298 9.481 µM 0.896267605356733 0.20185860146803 no 703 0.185054928113339 868 597396
SGTC_2064 5220758 200 µM 0.895748662235241 0.201995277283294 no 704 0.185193507099648 931 788518
SGTC_1390 3413-2614 145 µM 0.894608360368946 0.202295796973456 no 705 0.185498240553834 948 3421432
SGTC_2522 biochanin a 4.94 µM 0.893840503239828 0.202498311681459 no 706 0.185703617382572 903 5280373 A possible chelator.
SGTC_2092 5303694 80.6725 µM 0.893319936559546 0.202635674897584 no 707 0.185842932256012 907 1963699
SGTC_2260 7964312 200 µM 0.893212720730889 0.202663973117782 no 708 0.185871633572514 856 231951
SGTC_1531 st059297 52.4 µM 0.89269168494161 0.202801527345004 no 709 0.186011152235765 921 7566702
SGTC_409 arachidonic acid 100 µM 0.889524483535659 0.203638872594954 no 710 0.186860635475649 912 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1176 0848-0131 83.3 µM 0.888680669716816 0.203862307549387 no 711 0.18708736133989 991 6769040
SGTC_1432 4049-0298 68.4 µM 0.886775929215536 0.204367204012199 no 712 0.187599774742594 932 741646
SGTC_819 1013-0258 27.7 µM 0.885232806074753 0.204776790563404 no 713 0.188015541004104 919 5753198
SGTC_796 1234-0020 70.7 µM 0.876878423167066 0.207002732132783 no 714 0.19027633848426 911 46495034
SGTC_2635 hydroquinidine 100 µM 0.876703266888891 0.207049553481959 no 715 0.190323915937001 927 442912 An experimental heart treatment.
SGTC_2013 4024628 200 µM 0.876484202297508 0.207108120861562 no 716 0.19038343042643 882 5230760
SGTC_3216 9129716 49.47 µM 0.875540891896022 0.207360428821479 no 717 0.190639835332456 873 8056934
SGTC_1547 harmine 94.2 µM 0.875231093711696 0.207443330405134 no 718 0.190724089009678 1010 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_140 0062-0056 502.533 µM 0.874985510610123 0.207509062036586 no 719 0.190790894788438 1008 3758964
SGTC_2588 indole-3-carbinol 100 µM 0.87298004850965 0.208046295243013 no 720 0.191336976306442 967 3712 Induces cell cycle arrest.
SGTC_600 1495-0418 41.6 µM 0.872861067719837 0.208078194190033 no 721 0.191369404504872 910 5377768
SGTC_2297 7971671 152.32 µM 0.871517969582082 0.208438481207861 no 722 0.191735699291797 934 909016
SGTC_1425 4048-4433 7.33 µM 0.870714451795241 0.208654201195756 no 723 0.19195504280529 1001 23734946
SGTC_38 0929-0051 58.268 µM 0.870310657821145 0.20876265721147 no 724 0.192065328055596 997 1379719
SGTC_2504 purpurogallin 52.29 µM 0.870065366669839 0.208828556781498 no 725 0.192132341533072 900 5281571 An antioxidant.
SGTC_1238 0333-0287 48.8 µM 0.869086712996515 0.209091602456819 no 726 0.192399851824157 935 7226
SGTC_2456 5770359 74.46 µM 0.868834814744918 0.209159340037063 no 727 0.192468743840902 976 3118787
SGTC_2794 7785382 27.27 µM 0.867383650290224 0.209549822025669 no 728 0.192865918531545 1012 2205081
SGTC_373 0844-0104 25.9 µM 0.866955197301189 0.209665192881653 no 729 0.192983279112217 998 5375804
SGTC_2915 7971052 15.16 µM 0.866645811344991 0.209748525411099 no 730 0.193068052312235 799 5741558
SGTC_734 2023-0417 80 µM 0.864370818594435 0.210361888267934 no 731 0.193692109016125 937 3935732
SGTC_3301 9125354 19.7965 µM 0.864243359746701 0.210396283687063 no 732 0.193727108791515 876 41905162
SGTC_374 0880-0231 82.3 µM 0.862515535486192 0.210862871498312 no 733 0.194201943918617 969 6833587
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.859123823423796 0.211780544111846 no 734 0.195136102478764 863 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1467 k284-1082 293 µM 0.858854334026464 0.211853558117666 no 735 0.195210443239268 981 3334705
SGTC_1754 st042065 16.137 µM 0.85849538597703 0.211950832437192 no 736 0.195309488594284 1006 1126236 YIL048W NEO1
SGTC_1469 k284-2957 126 µM 0.85838462507192 0.211980853730406 no 737 0.195340057266942 971 23884841
SGTC_1665 st014639 11.4 µM 0.858201932510347 0.21203037724074 no 738 0.195390484559065 1016 981133 YIL048W NEO1
SGTC_3225 9130819 49.47 µM 0.858014204535617 0.212081272776872 no 739 0.195442309976337 975 4547121
SGTC_886 0866-0150 153 µM 0.857906960308781 0.212110351310693 no 740 0.19547192026863 1023 271463
SGTC_3284 9108171 64.8615 µM 0.856485824997594 0.212495902435986 no 741 0.195864555086303 902 8687505
SGTC_1667 st014849 34.6 µM 0.85583234058594 0.212673328749755 no 742 0.196045261908955 981 5348460
SGTC_881 0833-0569 170 µM 0.851981422902949 0.213720639573658 no 743 0.197112201438328 928 5418700
SGTC_2303 7774051 200 µM 0.850334025983682 0.214169588032651 no 744 0.197569702129808 939 2953184
SGTC_485 niflumic acid 177 µM 0.850046238868474 0.214248072015559 no 745 0.197649689668701 952 4488 A COX2 inhibitor.
SGTC_2840 9008771 71.43 µM 0.849900241317038 0.214287894194843 no 746 0.197690275704544 943 2992978
SGTC_722 3534-0461 190 µM 0.849869940723063 0.214296159500917 no 747 0.197698699634401 1002 658262
SGTC_2516 gossypol 71.55 µM 0.849808605744425 0.214312890841901 no 748 0.197715752160752 993 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2326 6164455 177.58 µM 0.849622833064649 0.21436357171681 no 749 0.19776740663608 918 2888790
SGTC_1269 0831-0796 3.05 µM 0.849078835442869 0.214512020466523 no 750 0.197918713187188 983 927758
SGTC_1739 st037196 92.5 µM 0.847701185558617 0.214888227572322 no 751 0.198302202971985 1019 612214
SGTC_493 zm226600 134 µM 0.845438941106651 0.215506829433002 no 752 0.198932905101505 981 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1623 st003709 20.3 µM 0.844410100292025 0.215788503242418 no 753 0.199220140118756 980 16192618
SGTC_1478 0453-0656 35.7 µM 0.843949973553433 0.215914544768709 no 754 0.199348680546431 995 5258496
SGTC_1831 st055328 12 µM 0.843683203954671 0.215987639921675 no 755 0.199423227830391 988 1103068
SGTC_1031 k035-0009 16 µM 0.843526349734835 0.216030624836071 no 756 0.199467067705536 1050 5180959
SGTC_588 3970-1144 52.9 µM 0.843345403960579 0.216080218044847 no 757 0.199517648240807 967 1888707
SGTC_2964 9083345 53.42 µM 0.84311536149882 0.216143277082545 no 758 0.199581964125124 921 17741579
SGTC_432 NS 1619 61.3 µM 0.843058636001738 0.216158828263843 no 759 0.199597825508183 907 4552 A K+/calcium channel activator.
SGTC_384 k007-0144 5.16 µM 0.842832863900577 0.216220729653849 no 760 0.199660962622936 994 6824886
SGTC_2257 7960413 200 µM 0.841935599326743 0.216466839885626 no 761 0.199912001203035 1010 2974689 YIL048W NEO1
SGTC_3344 9148862 3.898 µM 0.841665716957936 0.216540897479435 no 762 0.199987546579225 1006 4905352
SGTC_1816 st051957 91.6 µM 0.84092114682741 0.216745288678846 no 763 0.200196055366721 993 674121
SGTC_517 1365-0151 113 µM 0.839299551462371 0.21719081706382 no 764 0.200650617436771 947 768657
SGTC_898 1000-0849 28.3 µM 0.838317809491603 0.217460804573064 no 765 0.200926118081445 1017 6751807
SGTC_2753 fluvastatin 17.09 µM 0.837647751980773 0.217645187360145 no 766 0.201114282742578 964 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_562 3772-2733 112 µM 0.834893637815923 0.2184039963093 no 767 0.201888798625388 1048 2876874 YIL048W NEO1
SGTC_534 k292-0788 63.4 µM 0.834558949004133 0.218496312937952 no 768 0.201983041823298 1065 4146317
SGTC_2567 aureobasidin a 60 nM 0.834348548543748 0.218554358829415 no 769 0.20204230081966 949 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2970 9090938 41.86 µM 0.832617776748344 0.219032185988664 no 770 0.202530165000907 1041 17217104
SGTC_344 k064-0035 6.43 µM 0.83099632287648 0.219480377501724 no 771 0.202987853320027 954 5088750
SGTC_822 1487-0950 154 µM 0.830663947495257 0.219572315522173 no 772 0.203081749256021 1005 1958375
SGTC_1449 4112-4002 201 µM 0.829570666710771 0.219874882811251 no 773 0.203390783603657 927 2059539
SGTC_1445 4239-0156 97.7 µM 0.829317602655775 0.219944952801674 no 774 0.203462356418304 1075 4008346
SGTC_322 k048-0136 19.3 µM 0.828426799611531 0.220191705945809 no 775 0.203714417197659 978 6823282
SGTC_2472 5377652 49.4 µM 0.827734486539529 0.220383586797807 no 776 0.203910441953055 992 1610903
SGTC_2816 7982706 58.44 µM 0.826677008903826 0.220676861254562 no 777 0.204210077993608 965 2981853
SGTC_282 k297-0036 65.7 µM 0.824986180787504 0.221146249470255 no 778 0.204689718181838 992 5061378
SGTC_2811 7967822 32.47 µM 0.8238907161752 0.221450664419565 no 779 0.205000827989402 975 2232244
SGTC_1330 1469-0054 61.8 µM 0.821981492754375 0.221981784245626 no 780 0.20554371507573 1062 7102664
SGTC_3281 9140613 49.47 µM 0.821678716777804 0.222066079144661 no 781 0.205629887677806 962 16013766
SGTC_360 0957-0399 1.01 µM 0.820352872824996 0.222435418284097 no 782 0.206007486553378 1021 6752301 YPR165W RHO1
SGTC_1181 1222-0449 220 µM 0.81998113064728 0.22253903701488 no 783 0.206113432079009 1016 658318
SGTC_2078 5212016 200 µM 0.819916280849486 0.222557115947243 no 784 0.206131917406696 980 1899708
SGTC_919 tnp00227 403.569 nM 0.818815898592233 0.222864009937963 no 785 0.206445729369118 1026 1269246 A methoxyflavone. YNL221C POP1
SGTC_32 0928-0142 34.1 µM 0.815215866783736 0.223869733249233 no 786 0.207474378576179 1016 2244242
SGTC_644 1498-1197 63.3 µM 0.814456224816223 0.224082279795513 no 787 0.207691820064441 1042 6741615
SGTC_967 1306-0166 352 µM 0.813984448306784 0.224214339748741 no 788 0.207826930091526 1015 4437607
SGTC_1423 4048-0112 5.59 µM 0.810346902326467 0.225234046513027 no 789 0.208870412939209 1048 X1423
SGTC_433 pimozide 108 µM 0.810111502639525 0.225300126054811 no 790 0.208938046928081 983 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3316 9136639 10.545 µM 0.80821468177791 0.225832987113668 no 791 0.209483503665034 1016 4903665
SGTC_268 camptothecin 39.6153 µM 0.808120852693147 0.225859364371699 no 792 0.209510507226859 1064 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3269 9137823 49.47 µM 0.807795056681722 0.22595096576199 no 793 0.20960428565859 949 17682936
SGTC_71 0417-1750 47.813 µM 0.806954556769582 0.226187379188845 no 794 0.209846332499667 1033 6811472
SGTC_3243 9134147 49.47 µM 0.806625369853049 0.226280010026625 no 795 0.209941176379306 1092 24282180
SGTC_3092 9117248 49.47 µM 0.806148231900663 0.226414311259601 no 796 0.21007869196822 1099 17141857
SGTC_2150 5556613 200 µM 0.805835397282892 0.226502390041763 no 797 0.210168882525574 1046 743190
SGTC_1520 flindersine 88 µM 0.805704895066813 0.226539138739903 no 798 0.210206513176797 1068 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_731 3966-0296 387 µM 0.804805785439256 0.2267924144727 no 799 0.210465881291362 1046 660956
SGTC_2345 9052315 157.45 µM 0.799386649116945 0.228322343265826 no 800 0.212033124741787 1010 6469265
SGTC_2543 pimpinellin 60.67 µM 0.799380416131716 0.228324106293406 no 801 0.212034931275329 972 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_966 1300-0360 30.2 µM 0.799244195400703 0.228362638843491 no 802 0.212074414977269 1002 70588
SGTC_2924 9010168 62.78 µM 0.797114560465552 0.228965520369874 no 803 0.212692250384475 1053 2993929
SGTC_3242 9133940 49.47 µM 0.79705469608768 0.228982480361049 no 804 0.212709633009566 1102 17248444
SGTC_1966 st070145 16.1 µM 0.796476780054143 0.229146244202801 no 805 0.212877483262185 1033 3748532
SGTC_1014 4130-3005 69.3 µM 0.794180038955584 0.229797719689428 no 806 0.213545313649456 1067 743608
SGTC_2296 7971656 126.45 µM 0.792416211380505 0.23029873637259 no 807 0.214059014938234 1049 666570
SGTC_2705 st078069 42.8 µM 0.79228404083736 0.230336304110925 no 808 0.214097537542297 985 1530061
SGTC_50 0929-0078 56.389 µM 0.791350709823856 0.230601688689443 no 809 0.214369682266013 965 1377751
SGTC_2332 7982454 138.89 µM 0.79117260891706 0.230652349543086 no 810 0.214421636553298 1037 2981748
SGTC_1843 st055809 45.5 µM 0.790463498493476 0.230854117859451 no 811 0.214628565632468 992 16413835
SGTC_1164 k060-0068 93.7 µM 0.790104439513846 0.230956321084496 no 812 0.214733388688983 1103 5963676
SGTC_956 1185-0240 191 µM 0.786604333147768 0.231953920190708 no 813 0.215756760950431 1042 1416193
SGTC_2081 5214970 32.255 µM 0.785304873664224 0.232324901582261 no 814 0.216137419506754 1036 2063512
SGTC_2425 5628681 7.85 µM 0.78495637459669 0.232424450338175 no 815 0.216239573557047 1104 5714958
SGTC_1317 1273-0028 910 nM 0.783253689943543 0.232911163154801 no 816 0.216739076036323 1054 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1747 st037496 66.6 µM 0.77982482866667 0.233893019846528 no 817 0.217746994912096 1080 723305
SGTC_772 k072-0172 35.3 µM 0.779619280491684 0.233951951474832 no 818 0.217807501887814 1028 5861980
SGTC_3052 9092717 49.47 µM 0.778330871694129 0.234321531653243 no 819 0.218186990124973 1061 25237534
SGTC_2246 7293507 91.5585 µM 0.777780966384983 0.234479370376491 no 820 0.218349075313717 1110 887656
SGTC_3161 9100388 49.47 µM 0.776145173627099 0.234949237742996 no 821 0.218831636850277 1114 25236368
SGTC_1284 0929-0043 16 µM 0.776121294216593 0.234956100748545 no 822 0.218838685856678 1056 1239883
SGTC_75 0159-0059 199.013 µM 0.775021681305931 0.235272252366191 no 823 0.219163424075713 1043 5377270
SGTC_3204 9114183 49.47 µM 0.774398863667382 0.235451423882754 no 824 0.219347477712262 1042 17027248
SGTC_1042 0350-0096 82 µM 0.77432492858269 0.235472698448153 no 825 0.219369332734982 1040 3122515
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.77422476337502 0.235501522332813 no 826 0.219398943311064 1119 6728940
SGTC_1318 1280-3875 124 µM 0.773755960410957 0.235636452561319 no 827 0.219537560137727 1068 373245
SGTC_836 0330-0104 1.35 µM 0.773199940079655 0.235796540837416 no 828 0.219702030807085 1110 46494820
SGTC_2424 5537928 59.2 µM 0.770971752709799 0.236438677405777 no 829 0.220361837433253 1140 5382802
SGTC_1991 st073000 8.92 µM 0.770573978670263 0.236553412226487 no 830 0.220479744903107 1094 4301969 YIL048W NEO1
SGTC_980 1473-0395 201 µM 0.770077833277539 0.236696564425191 no 831 0.220626862092536 1030 768876
SGTC_2312 7706453 155.7 µM 0.769778448202908 0.236782968666582 no 832 0.220715663048396 1057 976098
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.769536550966647 0.236852794256985 no 833 0.220787427419226 1119 94937 An inhibitor of serotonin biosynthesis.
SGTC_1468 k284-1086 134 µM 0.768731667265084 0.237085211924467 no 834 0.221026310830445 1112 15996457
SGTC_2117 5521686 200 µM 0.767327971820243 0.237490841746809 no 835 0.221443270779893 1078 803312
SGTC_1207 2099-0101 141 µM 0.765857299198934 0.237916234468961 no 836 0.221880607942109 1131 5837381
SGTC_2374 9071832 200 µM 0.765095694334299 0.238136693109769 no 837 0.222107281790728 1067 17381698
SGTC_2857 9024691 58.44 µM 0.764522670004809 0.238302637884145 no 838 0.222277916163121 1087 16478292
SGTC_1762 st045503 25.4615 µM 0.761505836741777 0.239177340284503 no 839 0.223177496988044 1129 4645554
SGTC_897 1000-0139 31.4 µM 0.761467226060156 0.239188546447863 no 840 0.223189023612875 1087 6151020
SGTC_2505 galangin 7.89 µM 0.761115743346015 0.239290572155011 no 841 0.223293968952008 1001 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1748 st037455 53.6035 µM 0.757867043127669 0.240234704423148 no 842 0.224265290878973 1082 580690
SGTC_1500 4488-1866 171 µM 0.757822983625002 0.240247522865105 no 843 0.22427848060227 1158 2900003
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.757166787714496 0.240438477185633 no 844 0.224474972578426 1063 5379071
SGTC_775 4577-0580 57.3 µM 0.755080337693069 0.241046187213596 no 845 0.225100390008247 1128 2006902
SGTC_1710 st031758 61.5 µM 0.754057375007738 0.241344445373696 no 846 0.225407385375807 1089 5394341
SGTC_3303 9125618 40.5795 µM 0.752633976120867 0.241759789344106 no 847 0.22583494743677 1139 22695467
SGTC_2521 angolensin 13.4 µM 0.752567961891461 0.241779061527304 no 848 0.225854787983795 1108 821428 A flavenoid.
SGTC_54 0159-0055 9 µM 0.751436398052173 0.242109539682654 no 849 0.226195032215339 1114 3319099
SGTC_1295 1013-0063 9.78 µM 0.750682525723256 0.242329847255044 no 850 0.226421870946016 1127 6826038
SGTC_2556 citropten 84.59 µM 0.747926204767047 0.243136263464124 no 851 0.227252335206753 1134 2775 A potential DNA crosslinker.
SGTC_495 decylubiquinone 155 µM 0.747334194177399 0.243309656975888 no 852 0.227430928394538 1091 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1052 3253-3998 198 µM 0.745543476140223 0.243834545527803 no 853 0.227971619365146 1129 5450317
SGTC_2482 5981709 142.65 µM 0.745512006378005 0.243843775287446 no 854 0.227981127833579 1074 877755
SGTC_960 1222-0186 7.7 µM 0.744421836683821 0.244163627287209 no 855 0.228310656132112 1108 3126296
SGTC_747 3448-8087 38.7 µM 0.744005296237835 0.244285898513336 no 856 0.228436635495817 1137 5168703
SGTC_527 4476-4215 268 µM 0.743485734446279 0.244438456859157 no 857 0.228593827578439 1074 4418754
SGTC_2704 st078022 71.1 µM 0.741147473047175 0.245125672859474 no 858 0.229302013977659 1131 54697681
SGTC_3044 9093193 49.47 µM 0.739370396846462 0.245648650414393 no 859 0.229841056506395 1124 25236277
SGTC_201 4262-0159 12.803 µM 0.739130185242823 0.245719388475197 no 860 0.229913974554805 1083 1341029
SGTC_2701 st077767 14.721 µM 0.738737155426781 0.245835152375741 no 861 0.230033309649314 1146 5721188
SGTC_45 0kpi-0036 14.9 µM 0.738646058033962 0.245861988588526 no 862 0.230060974370738 1110 2795021
SGTC_430 0958-0115 16.4 µM 0.738028551971216 0.246043940005294 no 863 0.230248549481937 1047 6833180
SGTC_1652 st011932 78 µM 0.736410996035037 0.246520903637623 no 864 0.230740307384333 1107 1551076
SGTC_707 0865-0008 204 µM 0.735813013734227 0.24669735413089 no 865 0.230922250152009 1151 723043
SGTC_315 k915-0449 187 µM 0.733475932799237 0.247387619873628 no 866 0.231634100765533 1169 20970215 YNL149C PGA2
SGTC_3150 9097574 49.47 µM 0.733003170735669 0.247527377372268 no 867 0.231778247759076 1114 17217476
SGTC_2301 7769476 200 µM 0.732447765419819 0.247691619669075 no 868 0.231947656825417 1114 977820
SGTC_1224 0823-0416 294 µM 0.731525780750516 0.247964393829013 no 869 0.232229031664725 1147 3598164
SGTC_1631 benzylvanillin 81.9 µM 0.730377714374806 0.248304279443919 no 870 0.232579668351279 1130 75506
SGTC_1681 tripelennamine 100 µM 0.729868764788062 0.248455033641629 no 871 0.232735203300032 1156 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1712 st032288 53.4 µM 0.728332670503411 0.248910330429743 no 872 0.2332049839049 1158 2883011
SGTC_3240 9133527 49.47 µM 0.727169146659709 0.249255493062893 no 873 0.233561172097975 1114 17617455
SGTC_3045 9092950 49.47 µM 0.726675564858185 0.249401992343156 no 874 0.233712362806363 1167 44120432
SGTC_1970 st070122 35.8 µM 0.725387965633866 0.249784378070045 no 875 0.234107026924391 1179 102928
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.725347415651682 0.24979642548475 no 876 0.234119461956565 1138 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_785 1270-0111 65.3 µM 0.724863475751141 0.249940228016107 no 877 0.234267894890819 1167 6741994
SGTC_1134 3477-0009 42.5 µM 0.724454376020737 0.250061826083657 no 878 0.234393413640842 1172 3973534
SGTC_1941 st076221 61.8 µM 0.723878821281105 0.250232953249984 no 879 0.234570066607777 1169 2828568
SGTC_172 1112-0046 2.638 µM 0.723658931555687 0.250298348488873 no 880 0.234637576014376 1069 2802135 YIL048W NEO1
SGTC_2625 euphol 100 µM 0.721754924426243 0.250864979215282 no 881 0.235222583534788 1153 6708538 A triterpene alcohol.
SGTC_11 0438-0307 1.3 µM 0.720442217022707 0.251256034796783 no 882 0.235626382386312 1158 4011476
SGTC_974 1326-0144 138 µM 0.72006519464569 0.251368409329786 no 883 0.235742427996457 1178 5411856
SGTC_3212 9128307 49.47 µM 0.718240786203187 0.251912563960008 no 884 0.236304416818669 1092 27243542
SGTC_867 0518-0118 155 µM 0.717698341937927 0.252074475166023 no 885 0.236471652930416 1198 6848158
SGTC_2339 9000433 200 µM 0.71700672408256 0.252280991971975 no 886 0.236684973850688 1137 2988954
SGTC_3202 9113761 49.47 µM 0.716895645323725 0.252314168355673 no 887 0.236719244574437 1181 4798415
SGTC_584 0986-0246 15.4 µM 0.714558710114903 0.253012684012628 no 888 0.237440883037226 1265 53315 YDR232W HEM1
SGTC_3248 9135562 49.47 µM 0.714288443198535 0.253093533046041 no 889 0.237524418478791 1204 17650701
SGTC_2646 retinol 96.75 µM 0.713789502860892 0.253242824316444 no 890 0.237678675805251 1179 445354 A vitamin A analog and teratogen.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.713113088687487 0.253445292634075 no 891 0.237887890433132 1224 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_755 1995-0008 37.3 µM 0.712865358534766 0.253519465975368 no 892 0.237964538524849 1178 689533
SGTC_1983 st071813 46.9 µM 0.711431633816902 0.253948964044066 no 893 0.238408400975673 1142 11838595
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.710684077228861 0.25417305944401 no 894 0.238640014426952 1162 6708514
SGTC_1119 parthenolide 318.541 nM 0.710417546019152 0.254252982705541 no 895 0.238722622844585 1241 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1250 0485-0349 40.2 µM 0.709479632866942 0.254534334345873 no 896 0.239013443073217 1167 6842794 YDL195W SEC31
SGTC_3129 9127257 49.47 µM 0.707114083294108 0.255244666774661 no 897 0.239747792359631 1102 837894
SGTC_1968 st069590 43.6 µM 0.706261463411421 0.255500947215957 no 898 0.240012776896078 1145 6384066
SGTC_2993 9054257 71.4286 µM 0.706249746751341 0.255504469945218 no 899 0.240016419412416 1204 6470217 YGL055W OLE1
SGTC_2214 7179297 48.276 µM 0.706235158647158 0.255508856037898 no 900 0.240020954655484 1173 769744
SGTC_1887 st057648 70.8 µM 0.705926251651731 0.255601741954401 no 901 0.240117000606141 1169 688672
SGTC_2119 5528445 120.635 µM 0.704382174610034 0.256066298108142 no 902 0.24059740191346 1168 791935
SGTC_1614 st002383 48.6 µM 0.703607463227862 0.25629954615593 no 903 0.24083863114546 1209 1947235
SGTC_1166 k206-0078 225 µM 0.701367568199326 0.256974550276651 no 904 0.241536828138224 1198 5404595
SGTC_316 k060-0003 58.6 µM 0.698370935971559 0.257879045302214 no 905 0.242472623794995 1210 6152314
SGTC_93 0109-0045 59.227 µM 0.696566121883201 0.258424601286952 no 906 0.243037181775739 1272 88733
SGTC_2341 7987486 176.74 µM 0.693603138704239 0.259321541384499 no 907 0.243965562420862 1202 1258686
SGTC_660 4031-1742 102 µM 0.692595074591976 0.259627064046394 no 908 0.24428185109079 1135 6738706
SGTC_1676 st018489 23.4 µM 0.692223287839446 0.25973979154299 no 909 0.244398558108336 1198 3696235
SGTC_2057 5236571 38.335 µM 0.690327786852155 0.260314908806922 no 910 0.244994038767635 1203 54684039 YBR257W POP4
SGTC_699 0375-0592 111 µM 0.689376603180351 0.260603756126271 no 911 0.245293151520111 1239 762578
SGTC_1771 st048882 4.1505 µM 0.688539607869347 0.260858064098978 no 912 0.245556518464141 1188 4580403
SGTC_166 k072-0058 166.424 µM 0.68799102731027 0.261024810970487 no 913 0.245729215880893 1228 5846229
SGTC_1792 st045773 43.6 µM 0.687550393402873 0.261158785989439 no 914 0.245867978066956 1163 2919270
SGTC_3080 9117754 49.47 µM 0.685241612211719 0.261861349626819 no 915 0.246595734668967 1257 9550191
SGTC_1133 3473-0247 50 µM 0.685003278628442 0.261933929850297 no 916 0.246670926033098 1189 711311
SGTC_3211 9128781 49.47 µM 0.684984359941396 0.261939691639413 no 917 0.246676895176102 1177 17194361
SGTC_1913 st060213 96.1 µM 0.684367679490339 0.262127540605147 no 918 0.246871509897148 1236 688959
SGTC_1751 st044839 27.194 µM 0.684196087684764 0.262179821997591 no 919 0.246925676202946 1209 5291326
SGTC_1394 3474-0001 65.7 µM 0.68358762501386 0.262365254299045 no 920 0.247117800585379 1152 5017666 YIL048W NEO1
SGTC_1845 st056753 3.01 µM 0.682959611309079 0.262556715293872 no 921 0.247316182102041 1176 5375839
SGTC_2515 chrysin 20.77 µM 0.681975909074409 0.26285675784065 no 922 0.2476270921289 1215 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2404 5161160 200 µM 0.676274213052129 0.264599299208386 no 923 0.249433280930873 1196 2831543
SGTC_2757 clomiphene 4.22 µM 0.675266417613867 0.264907909715576 no 924 0.249753257948745 1283 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_161 4065-0411 162.148 µM 0.674346206810123 0.265189859451259 no 925 0.250045616933312 1229 1906281 YLR208W SEC13
SGTC_728 3030-5151 22.5 µM 0.673534192785153 0.265438784529721 no 926 0.250303751588342 1248 3125388
SGTC_1185 1319-0113 81.3 µM 0.671902261493244 0.265939415770403 no 927 0.250822960294457 1246 4672763
SGTC_2458 5808907 16.39 µM 0.671485434011144 0.266067363533806 no 928 0.250955667809887 1293 2731747
SGTC_922 1866-0035 480 µM 0.670960664901159 0.266228488964813 no 929 0.251122794081606 1227 3156169
SGTC_1054 3429-0080 167 µM 0.669181841249465 0.266775027310925 no 930 0.251689744132979 1249 1162877
SGTC_935 2996-0153 430 µM 0.667201228809384 0.267384231106677 no 931 0.252321803169255 1245 23738523
SGTC_1152 3909-8331 15.9 µM 0.666740894565988 0.267525922784771 no 932 0.252468826179239 1222 16001939
SGTC_1494 4358-1428 177 µM 0.666667418266864 0.267548542420259 no 933 0.252492297449799 1281 1564571
SGTC_2592 piperlongumine 83.33 µM 0.666344896741956 0.267647841886499 no 934 0.252595337331401 1212 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_912 3474-0017 2.18 µM 0.665738291614738 0.267834656679477 no 935 0.252789196857262 1282 3360550
SGTC_1193 1488-0126 41.5 µM 0.663932635002607 0.268391129102614 no 936 0.253366713853689 1268 1384710
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.662043647795302 0.268973904225344 no 937 0.253971624551932 1276 165521
SGTC_1907 st060210 83.7 µM 0.661849451328874 0.26903385214504 no 938 0.254033855050412 1271 688793
SGTC_314 1671-0008 2.74 µM 0.661417882512498 0.269167100268323 no 939 0.254172180451362 1187 3913060
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.66110718319487 0.269263050077976 no 940 0.254271789500575 1389 16725076
SGTC_1245 0418-0076 17.2 µM 0.660720748925882 0.269382412200852 no 941 0.254395707445773 1255 6790114
SGTC_1560 lithocholic acid 53.1 µM 0.656974356447825 0.27054097438825 no 942 0.25559870265918 1208 9903 A bile acid which acts as a detergent.
SGTC_2387 9077560 195.08 µM 0.655371323848992 0.271037467403876 no 943 0.25611435485355 1235 5303272
SGTC_151 3013-0144 2.285 µM 0.655315728407075 0.271054694636302 no 944 0.25613224813163 1234 906558 YHR107C CDC12
SGTC_1068 loratadine 26.9 µM 0.654662693520109 0.271257089938679 no 945 0.256342474853635 1245 3957 A H1 histamine antagonist.
SGTC_2809 7964133 12.99 µM 0.654632792392512 0.271266359007625 no 946 0.256352102856573 1270 1253665
SGTC_299 1273-0059 1.44 µM 0.654433777757959 0.271328055698675 no 947 0.256416189304303 1218 2848077
SGTC_1815 st051655 58.2 µM 0.653907907406894 0.271491114845315 no 948 0.256585569593022 1231 5984156
SGTC_64 000l-0018 272.079 µM 0.653704290890845 0.271554264303042 no 949 0.256651169131441 1221 6811119
SGTC_1848 st056003 16.4 µM 0.653607608879576 0.271584251743094 no 950 0.256682320425125 1312 146492
SGTC_1693 xanthone 101.9 µM 0.653532158222053 0.271607655091773 no 951 0.256706632267451 1306 7020 An insecticide.
SGTC_2799 7812892 81.82 µM 0.652780839664645 0.271840754488186 no 952 0.256948788834133 1254 20205235
SGTC_39 0986-0283 58.349 µM 0.647781347108132 0.273394396128596 no 953 0.258563190712483 1307 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1679 SEC14.276 6.7 µM 0.647402302596582 0.273512367015232 no 954 0.258685803034025 1292 1005053 YMR079W SEC14
SGTC_1995 st072814 61.1 µM 0.646634194675856 0.273751504229164 no 955 0.258934360828173 1222 5769371
SGTC_571 k831-0106 44.2 µM 0.645587133772127 0.274077655141416 no 956 0.259273385988508 1265 4783639
SGTC_1308 1187-1617 41.4 µM 0.644249347356472 0.274494643836334 no 957 0.25970687795015 1270 2882570
SGTC_3147 9097027 49.47 µM 0.644003932009479 0.274571173890556 no 958 0.259786442128463 1306 25236841
SGTC_2798 7813637 45.45 µM 0.641223547236807 0.275438940462081 no 959 0.260688726441275 1276 956368
SGTC_2913 7966556 36.57 µM 0.638456692585742 0.276303821498918 no 960 0.261588218331839 1255 2976516
SGTC_3329 9141233 27.5565 µM 0.638452250544945 0.276305211090843 no 961 0.261589663698914 1286 4909101 YNL103W MET4
SGTC_3180 9109287 49.47 µM 0.638175117275299 0.276391912740913 no 962 0.261679846415241 1266 18891271
SGTC_784 4579-0127 173 µM 0.63811482299885 0.276410777682769 no 963 0.261699469058085 1361 1948547
SGTC_2738 aclarubicin 5.55 µM 0.636872093475077 0.276799744894135 no 964 0.262104080798739 1223 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_905 2-aminofluorene 215 µM 0.636319897771636 0.276972664975542 no 965 0.262283969214654 1303 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1212 0520-0165 585 µM 0.634423178101665 0.277567025222306 no 966 0.262902343593693 1460 5403258
SGTC_2886 9058944 51.95 µM 0.633356109520237 0.277901677893074 no 967 0.263250559922934 1178 4949929
SGTC_845 0330-0138 4.51 µM 0.631211021455238 0.278575012938506 no 968 0.263951278245927 1293 9039800
SGTC_532 1548-0774 215 µM 0.627789268731502 0.279650730104399 no 969 0.26507099848554 1411 5932993
SGTC_2679 rapamycin 1 nM 0.627512575557433 0.279737803844454 no 970 0.265161647751735 1277 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_829 1635-0120 117 µM 0.62735852614543 0.279786288002837 no 971 0.265212123712025 1314 285054
SGTC_1900 st060200 72.8 µM 0.626819732102398 0.279955895363005 no 972 0.265388703787696 1293 688945
SGTC_1493 4348-0038 111 µM 0.623201680791133 0.281096113875983 no 973 0.266575998670736 1352 800424
SGTC_1706 st031321 9.9705 µM 0.622469699212848 0.281327068323284 no 974 0.266816531035215 1337 6103185
SGTC_538 2922-0838 53.3 µM 0.621983879940046 0.281480404321499 no 975 0.266976233910606 1356 777039
SGTC_162 k030-0015 37.8 µM 0.621457110891631 0.281646710582273 no 976 0.267149452702188 1358 1809920 YMR134W ERG29
SGTC_1032 k061-1018 98.7 µM 0.620821019956021 0.281847593984641 no 977 0.267358695673894 1440 4005393
SGTC_1853 st056710 91.2 µM 0.618346783689249 0.282629636609284 no 978 0.268173384516592 1449 269167
SGTC_628 1636-0253 16 µM 0.618323873758825 0.282636882721272 no 979 0.268180933875425 1292 4456143
SGTC_2462 5162487 171.77 µM 0.618024848037262 0.282731468841794 no 980 0.268279479663059 1282 2259986
SGTC_2678 equilin 100 µM 0.617076766057147 0.283031461270269 no 981 0.268592046373378 1370 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1393 3470-5649 58.2 µM 0.615908101388267 0.283401460660586 no 982 0.268977587178957 1265 4108395
SGTC_2069 5228469 200 µM 0.615006519670582 0.283687059910404 no 983 0.269275207409642 1277 2835210
SGTC_2938 9059746 27.26 µM 0.614083473990023 0.283979601159548 no 984 0.269580084097519 1306 6471769
SGTC_2211 7117706 200 µM 0.612066109162566 0.284619467440717 no 985 0.270247009639721 1289 822771
SGTC_736 0958-0254 92.6 µM 0.611650709371623 0.284751309056849 no 986 0.270384440026918 1371 6812352
SGTC_2922 7999257 32.47 µM 0.610970536462962 0.284967248572861 no 987 0.270609543045812 1320 2988377
SGTC_1077 5-fluorocytosine 377 nM 0.610687054278839 0.285057270807224 no 988 0.270703389017071 1330 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_603 3794-0023 45.9 µM 0.610367191286227 0.285158862361263 no 989 0.270809298260819 1325 3802260
SGTC_1351 1496-0003 46.5 µM 0.610096773441605 0.285244763120928 no 990 0.270898851944592 1306 3891978
SGTC_1375 2910-0797 186 µM 0.610052511133643 0.285258824631505 no 991 0.27091351160323 1342 742508
SGTC_2936 9038235 15.59 µM 0.609030600027955 0.285583563166168 no 992 0.271252078185739 1315 4749415
SGTC_2477 5967686 25.23 µM 0.607317933419592 0.286128201216474 no 993 0.271819969626702 1302 776118
SGTC_120 rhodamine 6G 52.259 µM 0.605797822859621 0.286612018264333 no 994 0.272324507810924 1333 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1169 aniline yellow 25.8 µM 0.603478325963671 0.287351008856503 no 995 0.273095264935191 1329 6051 A DNA damaging agent.
SGTC_817 1391-0715 46 µM 0.601215081134321 0.288072945311245 no 996 0.273848370479382 1301 1353946
SGTC_1397 3532-0190 20.1 µM 0.600589063619973 0.288272785232436 no 997 0.274056861954769 1302 5322280
SGTC_1018 4259-0013 28.1 µM 0.600374773123231 0.28834120695577 no 998 0.274128248167689 1354 6801262
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.599597240979857 0.28858953277222 no 999 0.274387343178491 1310 803109
SGTC_1508 1080-0625 72.9 µM 0.599565985222162 0.288599517245753 no 1000 0.274397760979899 1295 767111
SGTC_1301 naphtanilide LB 4.81 µM 0.599134759615813 0.288737286413798 no 1001 0.274541511950136 1415 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.597438394628458 0.289279546162463 no 1002 0.27510736305254 1315 6312947
SGTC_930 2810-3379 265 µM 0.597285688597766 0.289328383619856 no 1003 0.275158328885536 1488 1015764
SGTC_171 k064-0041 9.68 µM 0.596709543776523 0.289512677414665 no 1004 0.27535065980665 1296 53325
SGTC_156 3474-0145 5.642 µM 0.593799009847076 0.290444523409187 no 1005 0.276323275697253 1300 2265471
SGTC_2737 bleomycin 30.5 nM 0.593009812957656 0.290697436998233 no 1006 0.276587292536186 1367 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1819 st053448 58.6 µM 0.592414483031081 0.290888290254719 no 1007 0.276786535172973 1350 2857616
SGTC_181 1447-1644 8.07 µM 0.590207223097671 0.291596413095766 no 1008 0.277525865082597 1322 534600
SGTC_2062 5245942 200 µM 0.588947513844657 0.292000907048491 no 1009 0.277948241503325 1407 1376160
SGTC_1873 rapamycin 2 nM 0.588406239115246 0.292174791132625 no 1010 0.278129825473822 1360 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2967 9089538 49.85 µM 0.586278733588252 0.292858717040411 no 1011 0.278844109874601 1416 728216
SGTC_2771 fluoxetine 41.05 µM 0.58382028042593 0.293649956425294 no 1012 0.279670616120007 1404 3386 A selective serotonin reuptake inhibitor.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.581230329496577 0.294484586404853 no 1013 0.280542614551362 1322 1241132 A phosphatase inhibitor.
SGTC_2680 butyl paraben 22.24 µM 0.580730006013293 0.294645945279379 no 1014 0.280711217635498 1395 7184 An antifungal and steroid mimetic.
SGTC_1874 staurosporine 7.6 µM 0.580310900127565 0.294781142121942 no 1015 0.280852489063655 1411 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1061 3448-9325 110 µM 0.580184050959127 0.294822067268564 no 1016 0.280895253919086 1331 723482
SGTC_1279 0874-0590 65.2 µM 0.579779332856409 0.294952658336364 no 1017 0.281031718194647 1387 3523074
SGTC_2277 7947813 106.88 µM 0.577884206014592 0.295564516400948 no 1018 0.281671149572233 1455 1246798
SGTC_687 k029-0044 34.9 µM 0.576779492061707 0.295921451862853 no 1019 0.282044212500988 1425 5829338
SGTC_2859 9028643 45.46 µM 0.576536960931615 0.295999840683852 no 1020 0.282126147331687 1330 17151580
SGTC_2252 omeprazole 400 µM 0.576248994396649 0.296092927121035 no 1021 0.28222344658426 1343 4594 A proton pump inhibitor.
SGTC_277 nystatin 15.5 µM 0.575887792118549 0.296209706320798 no 1022 0.282345513843109 1339 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_412 gemfibrozil 100 µM 0.574051180843421 0.296803822035698 no 1023 0.282966583889573 1360 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_680 0417-1641 114 µM 0.571969647711285 0.29747782486842 no 1024 0.283671268866735 1359 2835990
SGTC_2575 plumbagin 510 nM 0.570757270623882 0.297870715777901 no 1025 0.284082095607693 1337 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_383 2324-0395 7.37 µM 0.570703763560957 0.297888061079921 no 1026 0.28410023359468 1431 3146421
SGTC_2700 st077718 96.8 µM 0.569922994764893 0.298141214066908 no 1027 0.284364963966894 1385 904970
SGTC_781 4335-2806 94.4 µM 0.569891713723311 0.298151358533682 no 1028 0.284375572688802 1494 845254
SGTC_1828 st055811 49 µM 0.567875543944861 0.298805535379826 no 1029 0.285059739594344 1360 5877589
SGTC_643 k048-0106 28.4 µM 0.567745370964359 0.298847794384333 no 1030 0.285103939439849 1423 6763920
SGTC_2100 5377183 190 µM 0.56744301659773 0.298945960366057 no 1031 0.285206615564031 1435 2844202
SGTC_1372 2752-0194 270 µM 0.566473168716963 0.299260941561489 no 1032 0.285536083795862 1339 823334
SGTC_1570 verbenone 133 µM 0.565515879648832 0.299571991556906 no 1033 0.285861463214235 1434 29025 A natural terpanoid with antifungal properties.
SGTC_3330 9141424 71.43 µM 0.563532498926055 0.30021691320798 no 1034 0.286536168295263 1444 27261020
SGTC_777 1315-0167 517 µM 0.563414096623089 0.300255433080893 no 1035 0.286576470193106 1341 4221767
SGTC_3099 9120367 49.47 µM 0.563113484697369 0.300353241325377 no 1036 0.286678804867625 1388 24824940
SGTC_1256 0570-0116 285 µM 0.561531640215491 0.300868153324886 no 1037 0.287217583562592 1370 410638
SGTC_2986 9022445 71.43 µM 0.561456056345581 0.300892766871338 no 1038 0.28724333953904 1420 6459286
SGTC_3307 9126885 69.2785 µM 0.560887505349604 0.301077942039135 no 1039 0.287437114130842 1362 24824909
SGTC_339 3091-4833 71.4 µM 0.560514491424619 0.301199459328093 no 1040 0.287564278997772 1390 3240077
SGTC_3347 9188721 44.724 µM 0.558424495116294 0.301880728768714 no 1041 0.288277275035643 1403 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1037 k284-1091 78.7 µM 0.558134312280445 0.301975373461432 no 1042 0.288376335925571 1367 3334711
SGTC_2848 9016370 25.97 µM 0.557375511354801 0.302222923436515 no 1043 0.28863544669135 1431 7894410
SGTC_2476 5806916 10.51 µM 0.556240758921259 0.302593293046357 no 1044 0.28902313960477 1379 2870194
SGTC_2116 5511452 16.8835 µM 0.554186143613255 0.303264411909979 no 1045 0.289725730139697 1422 870744
SGTC_3060 1327-0027 12.5 µM 0.554099803800028 0.303292628481398 no 1046 0.289755272201623 1350 16000455 YPR107C YTH1
SGTC_2945 9067681 61.76 µM 0.552646258019411 0.303767835434432 no 1047 0.290252830019342 1455 16456930
SGTC_2354 9060492 162 µM 0.548991567891236 0.304964126432933 no 1048 0.291505618249068 1492 6471895
SGTC_2016 5121758 140 µM 0.547827624929205 0.30534555919822 no 1049 0.291905134127431 1375 2795203
SGTC_1221 2958-7315 257 µM 0.546170488771568 0.305888979812187 no 1050 0.292474374952785 1425 4562705
SGTC_3271 9137798 49.47 µM 0.543979593598638 0.306608091036637 no 1051 0.293227757718771 1436 6498326
SGTC_2719 novobiocin 32.65 µM 0.543842290700512 0.306653182412878 no 1052 0.293275001986575 1490 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2726 cimetidine 79.27 µM 0.543321359592376 0.306824286990026 no 1053 0.29345428016366 1420 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3030 9087619 49.47 µM 0.543033315577946 0.306918915751586 no 1054 0.293553432156168 1385 25236973
SGTC_3111 9122088 49.47 µM 0.538566989349884 0.308387844858611 no 1055 0.295092835148656 1370 16876704
SGTC_536 3852-0578 10.6 µM 0.538199186892382 0.308508948594841 no 1056 0.295219770673833 1517 2869208
SGTC_1740 st038286 13.222 µM 0.538176837064202 0.308516308237706 no 1057 0.295227484828672 1465 716786
SGTC_1275 0867-0008 21.1 µM 0.537577327985957 0.308713751107234 no 1058 0.295434442998678 1449 3422836
SGTC_1999 st074831 12.5 µM 0.5373762264242 0.308779994470912 no 1059 0.295503880763791 1395 17112523
SGTC_1093 fluphenazine 7.97 µM 0.535741569993348 0.309318685120344 no 1060 0.296068584701132 1475 6602611 An atypical antipsychotic.
SGTC_1172 0370-0043 85 µM 0.535716729895366 0.309326874183017 no 1061 0.296077169712404 1473 376585
SGTC_859 0439-0102 54.6 µM 0.535480281919756 0.309404828990462 no 1062 0.296158894454171 1459 610143
SGTC_988 1497-1057 103 µM 0.535147468254467 0.309514569248303 no 1063 0.296273944102609 1473 3533044
SGTC_1648 st011736 69.8 µM 0.534977912434339 0.309570484240394 no 1064 0.296332565373753 1489 2855514
SGTC_488 nitrendipine 139 µM 0.533742025601727 0.309978179887093 no 1065 0.296760014469723 1471 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1309 pyrazolanthrone 13.4 µM 0.532699423497864 0.310322296382302 no 1066 0.29712083264219 1515 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1111 tnp00062 510.699 nM 0.532410360671405 0.310417732566276 no 1067 0.297220905466579 1545 676306
SGTC_1249 0481-0015 10.2 µM 0.53195978255441 0.310566519646747 no 1068 0.297376925192611 1390 4227577
SGTC_1479 0549-0158 134 µM 0.530806346964449 0.310947541097993 no 1069 0.297776490683347 1455 5440202
SGTC_725 1497-0963 19 µM 0.530415118534269 0.31107682405584 no 1070 0.297912073032313 1544 3549977
SGTC_3185 9108267 49.47 µM 0.530219820632384 0.311141369733359 no 1071 0.297979765116699 1388 4910486
SGTC_1793 st048256 72.231 µM 0.52997234778334 0.311223167499692 no 1072 0.298065551596061 1382 672022
SGTC_487 nimodipine 119 µM 0.528774032064826 0.311619381348252 no 1073 0.298481106904568 1413 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3066 9117245 49.47 µM 0.526878359115736 0.312246616513624 no 1074 0.299139031471698 1541 17176980
SGTC_102 gallobenzophenone 83.616 µM 0.526789621602561 0.312275991098883 no 1075 0.29916984541098 1517 70837
SGTC_997 3996-0078 137 µM 0.526691045075182 0.31230862407058 no 1076 0.299204077618846 1455 735687
SGTC_2002 4023503 131 µM 0.526096528551696 0.312505465224037 no 1077 0.299410570256016 1521 4736863 YCR052W RSC6
SGTC_1891 st059073 26.2 µM 0.525923232667976 0.312562852612292 no 1078 0.299470773046979 1568 688754
SGTC_252 miconazole 1.30953 nM 0.524718488777273 0.312961932292961 no 1079 0.299889451288177 1417 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2491 paeonol 100 µM 0.524646773102504 0.312985695521275 no 1080 0.299914382608935 1417 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3041 9091929 49.47 µM 0.523522572637582 0.313358304596656 no 1081 0.300305323517884 1490 25236887
SGTC_1884 5633444 25 µM 0.521742025021693 0.313948845637777 no 1082 0.300924980057535 1467 5724239
SGTC_2843 9000894 45.46 µM 0.520415339112592 0.314389167839239 no 1083 0.301387060609493 1350 2242070
SGTC_2273 7815444 169.05 µM 0.520166950507507 0.314471636491509 no 1084 0.301473609070766 1554 2824616
SGTC_576 1073-0113 22.7 µM 0.518385289135841 0.315063445329921 no 1085 0.302094738256427 1553 5439563
SGTC_117 lucigenin 22.078 µM 0.518048475545951 0.315175377074484 no 1086 0.302212223968446 1406 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_582 0987-0078 156 µM 0.515554878558156 0.316004590297445 no 1087 0.303082665691707 1456 1625765
SGTC_2814 7977482 42.97 µM 0.51073346965111 0.317610512218145 no 1088 0.304768850507136 1577 6456762
SGTC_2234 tolnaftate 200 µM 0.510375170908908 0.317729992490923 no 1089 0.304894324150027 1474 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2740 felodipine 17.08 µM 0.509977185050675 0.31786272930187 no 1090 0.305033722835473 1541 3333 L-type calcium channel blocker
SGTC_398 bronopol 33.3 µM 0.507914559895501 0.318551033689309 no 1091 0.305756631714583 1488 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2372 9071633 200 µM 0.506614003666646 0.318985355627045 no 1092 0.306212840336437 1506 21321366
SGTC_924 2046-0044 21.3 µM 0.505843538793206 0.319242770401795 no 1093 0.306483245577985 1428 3623589
SGTC_2293 7624732 200 µM 0.503766609472136 0.319937113034491 no 1094 0.307212697197271 1409 894453
SGTC_892 0929-0076 29 µM 0.502797644217039 0.320261265978729 no 1095 0.307553275050323 1468 5751038
SGTC_2485 5633444 17.78 µM 0.501492075677531 0.320698241516621 no 1096 0.30801242671097 1427 5724239
SGTC_1128 3448-9350 235 µM 0.50077807575929 0.320937323433315 no 1097 0.308263658535521 1463 619386
SGTC_1446 4239-0190 62 µM 0.500412811536641 0.321059660390411 no 1098 0.308392217099702 1454 1340085
SGTC_186 3455-3465 67.277 µM 0.499073745128211 0.321508316339157 no 1099 0.308863716428546 1461 755278
SGTC_613 3914-0030 117 µM 0.498417547645326 0.321728271312817 no 1100 0.309094885563383 1410 1145395
SGTC_231 b-estradiol 524 µM 0.497665652696022 0.321980380554169 no 1101 0.309359860528549 1422 450 A steroid.
SGTC_1969 st069479 40.1 µM 0.496519893385555 0.322364709488643 no 1102 0.309763827718856 1568 3895485
SGTC_309 k408-0051 1.48 µM 0.496348635504144 0.322422171877043 no 1103 0.30982422888884 1474 3640463
SGTC_1742 st038235 28.8875 µM 0.496117578240393 0.322499705556693 no 1104 0.309905728919118 1504 564103 YBR002C RER2
SGTC_3154 9100113 49.47 µM 0.494649714220194 0.322992442866098 no 1105 0.310423701597363 1437 25237525
SGTC_2120 5538279 151.968 µM 0.493674652228212 0.323319926681369 no 1106 0.31076798472203 1523 2058197
SGTC_1178 0988-0033 191 µM 0.492868549566307 0.323590767323671 no 1107 0.31105273543799 1515 5392207
SGTC_1883 5-benzylidenerhodanine 20 µM 0.491598977835917 0.324017517410644 no 1108 0.311501433089625 1561 1273210
SGTC_1571 st070080 73.4 µM 0.490649141641084 0.324336943887444 no 1109 0.311837311614163 1600 4315245
SGTC_356 1634-0012 32.5 µM 0.489451357451006 0.324739938718868 no 1110 0.312261092023447 1533 735457
SGTC_2869 9037858 32.47 µM 0.487899411740544 0.325262396490183 no 1111 0.312810545603958 1431 27187042
SGTC_1787 fluconazole 80 µM 0.487683092692795 0.325335246947098 no 1112 0.312887164651115 1431 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2889 9059656 51.95 µM 0.487601182907927 0.325362833709506 no 1113 0.312916178767875 1559 3949838
SGTC_2321 7390090 138.78 µM 0.486856847454838 0.325613565615296 no 1114 0.313179890663714 1435 649046
SGTC_654 1124-0271 80.9 µM 0.486810501585766 0.3256291799886 no 1115 0.31319631378402 1459 5403748
SGTC_2941 9056145 11.23 µM 0.484025283568522 0.326568107832639 no 1116 0.314183962798849 1434 2119517
SGTC_1405 3909-7894 12 µM 0.483810676970412 0.326640499799681 no 1117 0.314260118484115 1580 7104060
SGTC_2255 7941087 197.44 µM 0.481383598053187 0.327459665720559 no 1118 0.315121945869391 1609 935561
SGTC_2086 5274770 176.623 µM 0.480973983834035 0.327597997146613 no 1119 0.315267494568857 1507 689278
SGTC_3009 9080819 71.4286 µM 0.479704439030135 0.328026887298467 no 1120 0.315718785507909 1503 17027216
SGTC_448 monastrol 171 µM 0.478811144144392 0.328328805005843 no 1121 0.316036493968396 1539 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.47682508710922 0.32900045843544 no 1122 0.316743339973046 1762 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1130 3454-2858 15.9 µM 0.474452653229414 0.329803502568249 no 1123 0.317588576734011 1487 715628 YIL048W NEO1
SGTC_3135 9127742 49.47 µM 0.472591098310127 0.330434169491747 no 1124 0.318252467261037 1502 3643468
SGTC_3244 9134489 49.47 µM 0.471946571979268 0.330652637755946 no 1125 0.318482462406789 1465 16584271
SGTC_1280 0880-0253 10.1 µM 0.471367773059385 0.330848876279406 no 1126 0.318689062775298 1502 6836607
SGTC_857 0438-0306 1.35 µM 0.47083739695131 0.331028738142676 no 1127 0.318878428278638 1528 4686136
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.470405513339416 0.331175227910225 no 1128 0.319032662955583 1496 4330530
SGTC_1399 3562-5772 25 µM 0.470180344817182 0.331251612636363 no 1129 0.319113087777202 1481 23847490
SGTC_1555 citronellol 128 µM 0.470166754564079 0.331256223131435 no 1130 0.319117942163733 1616 8842 A terpine precursor.
SGTC_1876 myriocin 605 nM 0.470050136346709 0.33129578692774 no 1131 0.319159599020819 1621 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1127 asiatic acid 681.4 nM 0.468469651628645 0.331832166357294 no 1132 0.319724384414127 1501 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2971 9092186 9.93 µM 0.468423595404533 0.331847801935848 no 1133 0.319740848860004 1414 25236400
SGTC_230 MPP+ 141.667 µM 0.468214265464004 0.331918870825137 no 1134 0.319815685815849 1482 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3142 9086498 49.47 µM 0.4671376730067 0.332284476525743 no 1135 0.320200691163053 1502 25236367
SGTC_443 clozapine 122 µM 0.46444223651013 0.333200533672841 no 1136 0.321165467717116 1550 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2445 5742597 35.57 µM 0.463413222945307 0.333550511915085 no 1137 0.321534101200789 1490 1774255
SGTC_19 0279-0214 38.434 µM 0.462724022749885 0.333784997139447 no 1138 0.321781098391943 1557 3566274 YBR002C RER2
SGTC_2139 5578692 56.4705 µM 0.461829061145094 0.334089585051613 no 1139 0.322101954402618 1617 650991 YMR113W FOL3
SGTC_2140 5586273 200 µM 0.458983539041935 0.335058744954472 no 1140 0.323122993454531 1528 854421
SGTC_1079 idarubicin 2.36 µM 0.458030165089349 0.335383701940449 no 1141 0.323465384808276 1551 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3275 9138069 49.47 µM 0.456965859327604 0.335746615506665 no 1142 0.323847792468357 1585 17617007
SGTC_194 1486-1323 56.904 µM 0.455666023959204 0.336190049261627 no 1143 0.324315078794325 1510 5178754
SGTC_2227 7312221 64.1025 µM 0.454569706492177 0.336564230985492 no 1144 0.32470941638704 1570 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2136 5328288 199.296 µM 0.453388292737394 0.336967637969147 no 1145 0.32513458254489 1519 262395
SGTC_2152 5568786 200 µM 0.453167733437645 0.337042971210827 no 1146 0.325213982482179 1533 5399883
SGTC_3069 9117009 49.47 µM 0.45268180311723 0.337208966443321 no 1147 0.325388942289678 1507 41904981
SGTC_672 1441-0018 53.7 µM 0.451031143690016 0.337773073127706 no 1148 0.325983551487923 1509 251141
SGTC_2720 fluspirilene 36.88 µM 0.450996941761727 0.337784765368693 no 1149 0.325995876573442 1588 3396 An atypical antipsychotic.
SGTC_2777 climbazole 1.536 µM 0.450169983195455 0.338067516321647 no 1150 0.326293939106892 1584 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_993 3909-8757 62.7 µM 0.449580170164544 0.338269239090155 no 1151 0.326506594557424 1570 4288324 YLR208W SEC13
SGTC_609 0986-0026 86.3 µM 0.448597138207685 0.338605550367793 no 1152 0.326861149299342 1601 2848610
SGTC_3251 9135047 49.47 µM 0.448002814401578 0.338808940707383 no 1153 0.327075582724854 1648 17682963
SGTC_3356 9151811 4.48 µM 0.447291154999288 0.339052547642904 no 1154 0.327332426229441 1520 1859254 YPR165W RHO1
SGTC_27 0485-0001 32.618 µM 0.444348325679291 0.34006061630036 no 1155 0.328395383636096 1569 2054479
SGTC_546 peri-Naphthalide 147 µM 0.443787318016738 0.340252920050101 no 1156 0.328598179100225 1650 223824 A penicillin ester.
SGTC_942 3253-1115 227 µM 0.443331510311218 0.340409193669155 no 1157 0.328762983613758 1652 46497897
SGTC_2741 miltefosine 3.04 µM 0.44089200135772 0.341246044349411 no 1158 0.32964559227882 1559 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_289 k017-0060 526 µM 0.439718672822678 0.3416488222546 no 1159 0.330070438349244 1556 5512909
SGTC_1398 3558-0053 112 µM 0.439639740908604 0.3416759243262 no 1160 0.330099026382076 1539 4532369
SGTC_2004 4023728 41.89 µM 0.43764646064694 0.342360607500422 no 1161 0.330821293024469 1664 360084 YDR527W RBA50
SGTC_800 3448-7362 155 µM 0.437032639851007 0.342571556809987 no 1162 0.331043838515602 1624 15991913
SGTC_109 0132-0036 33.701 µM 0.435994629872891 0.342928397217583 no 1163 0.331420312908077 1533 67274 A color developer.
SGTC_3193 9111931 49.47 µM 0.435399623041355 0.343133008064915 no 1164 0.331636191969249 1601 17087244
SGTC_1885 st057546 99.9 µM 0.434204574070608 0.343544100227577 no 1165 0.332069945915548 1636 702008
SGTC_2106 5357045 167.29 µM 0.433830772236697 0.343672724625638 no 1166 0.332205666954215 1653 668842
SGTC_2683 piperine 63.03 µM 0.42997105000985 0.345001902622476 no 1167 0.333608350166143 1575 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2431 5490079 200 µM 0.426404037820562 0.346231982904914 no 1168 0.33490672982538 1557 5722345
SGTC_478 N-arachidonylglycine 10 µM 0.425663690581161 0.346487494778018 no 1169 0.335176461681475 1593 5283389
SGTC_535 2293-4129 48.2 µM 0.425629408505983 0.346499328050892 no 1170 0.335188953783445 1695 396118 YIL048W NEO1
SGTC_1785 bathophenanthroline 24 µM 0.425555383560786 0.346524880030686 no 1171 0.335215928477155 1525 72812 An iron chelator.
SGTC_3027 9089541 49.47 µM 0.422040961757777 0.34773879225109 no 1172 0.33649755964509 1573 9943819
SGTC_882 0843-0131 351 µM 0.420793747273023 0.348169967446097 no 1173 0.336952848949901 1617 5425421
SGTC_1895 st058434 18.3 µM 0.418547904057897 0.348946873895497 no 1174 0.337773284878539 1717 5393175
SGTC_1367 1812-0510 76.9 µM 0.418467410766175 0.348974730789722 no 1175 0.337802704474607 1617 1142582 YDR527W RBA50
SGTC_844 0330-0132 15.3 µM 0.416182689934449 0.349765759538954 no 1176 0.338638162668805 1672 2828079
SGTC_132 0417-1715 25.805 µM 0.416172592165579 0.349769257095642 no 1177 0.338641856905842 1742 6769098
SGTC_2254 7938975 95.19 µM 0.416124304833114 0.3497859825193 no 1178 0.338659522889434 1711 2969277
SGTC_2508 celastrol 40.54 µM 0.415751592957771 0.34991508962128 no 1179 0.338795891957002 1544 122724 Celastrol is a natural product and antioxidant.
SGTC_1827 berberine 7.24 µM 0.415391388115571 0.350039880787464 no 1180 0.338927704990573 1478 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_352 k048-0007 5.11 µM 0.415046546791902 0.350159364515206 no 1181 0.33905391439244 1585 6811911
SGTC_2190 6049624 200 µM 0.413555760833809 0.350676076012103 no 1182 0.339599738848816 1646 2265554
SGTC_2358 9037157 4 µM 0.413038823285355 0.350855312907956 no 1183 0.339789084881708 1644 2388925
SGTC_2328 6201408 200 µM 0.412216882252524 0.351140371494623 no 1184 0.340090232095414 1585 2890418
SGTC_1089 terbinafine 2.25 µM 0.412187604744956 0.351150526816543 no 1185 0.340100960830708 1677 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3023 9089636 49.47 µM 0.410752018806895 0.35164861057739 no 1186 0.340627189608277 1676 17249241
SGTC_1692 fluoroquinolonic acid 71 µM 0.410718268641448 0.351660323435567 no 1187 0.340639564816161 1648 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2611 pyromycin 23.93 µM 0.409622899219666 0.352040543348945 no 1188 0.341041298113141 1575 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1810 st050138 53 µM 0.408886985209745 0.352296073781178 no 1189 0.341311300263079 1702 3444541
SGTC_79 0052-0007 94.094 µM 0.408519434190099 0.35242372300757 no 1190 0.341446182818949 1705 2801472
SGTC_447 ml7 120 µM 0.407565581738599 0.35275507025705 no 1191 0.341796318621856 1685 4216 Selective myosin light chain kinase inhibitor.
SGTC_2525 harmine 47.85 µM 0.4074435873695 0.352797456466962 no 1192 0.34184110958313 1679 5280953 A monoamine oxidase inhibitor
SGTC_2417 cerulenin 830 nM 0.405228662386292 0.3535673361071 no 1193 0.342654719136875 1629 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1607 st000305 50.6 µM 0.404432701060827 0.353844148671994 no 1194 0.342947278648012 1663 5457690
SGTC_1025 k007-0731 70 µM 0.404191652009059 0.353927993884993 no 1195 0.343035896005229 1588 6256118
SGTC_1012 4112-3522 18 µM 0.404046131450226 0.353978614407517 no 1196 0.343089398206654 1732 3112398
SGTC_2623 humulene 100 µM 0.400733989774237 0.355131466471928 no 1197 0.344307991573363 1582 6187145 An anti-inflammatory.
SGTC_514 4466-0038 2.65 nM 0.397176376442837 0.356371238055585 no 1198 0.34561870070396 1671 5722064
SGTC_2856 9022925 19.48 µM 0.396531579918483 0.356596102414665 no 1199 0.345856457839345 1644 4944862
SGTC_3234 9132280 49.47 µM 0.394380608484903 0.357346585739047 no 1200 0.346650029139814 1637 17612295
SGTC_1453 4237-0541 195 µM 0.39415894205694 0.357423957551788 no 1201 0.346731848247968 1760 739892
SGTC_250 brefeldin a 552.239 µM 0.394005711767216 0.357477445420493 no 1202 0.346788411130088 1608 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_308 4092-1169 104 µM 0.391922643478932 0.358204856306847 no 1203 0.347557685824649 1644 2268590 YDL196W YDL196W
SGTC_611 3453-1652 23.7 µM 0.391487653212785 0.358356820709814 no 1204 0.347718406617347 1725 1560575
SGTC_1797 st048695 56.8 µM 0.391071197086208 0.358502331210991 no 1205 0.347872305038844 1732 592262 YIL048W NEO1
SGTC_303 1348-1668 34.2 µM 0.38907557158255 0.359199891052474 no 1206 0.348610121812335 1663 5380509
SGTC_139 0099-0334 718.624 µM 0.388610626746347 0.359362477483615 no 1207 0.34878210225209 1687 97690
SGTC_1789 tunicamycin 25 nM 0.387992429198783 0.359578694251801 no 1208 0.349010818119061 1661 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1262 0737-0114 49.6 µM 0.387255241832584 0.359836586897802 no 1209 0.349283628619541 1751 765919
SGTC_1444 4112-3581 28 µM 0.386409534678621 0.360132521980426 no 1210 0.349596694903865 1659 2877249
SGTC_2232 chlorophetanol 41.5365 µM 0.386139444785236 0.360227051179492 no 1211 0.34969669911691 1745 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3084 9116877 49.47 µM 0.385801154974526 0.36034546183302 no 1212 0.349821969928026 1739 27241325
SGTC_2492 derrusnin 100 µM 0.384529013257092 0.360790865933478 no 1213 0.35029319813339 1604 1715307 Part of coumarin class of compounds.
SGTC_1206 3978-0017 132 µM 0.38227390061901 0.361580893116046 no 1214 0.351129105790109 1734 3873677
SGTC_749 1000-0129 128 µM 0.382256312485863 0.361587057041385 no 1215 0.351135628060812 1789 708470
SGTC_1557 sumaresinolic acid 42.3 µM 0.382150811746349 0.361624031513627 no 1216 0.351174752200016 1598 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1504 k297-0033 30 µM 0.381938700366749 0.361698373351045 no 1217 0.351253416849947 1591 4388117
SGTC_1690 st023502 41.2 µM 0.380960533485225 0.362041273586823 no 1218 0.351616266956213 1744 24207482
SGTC_1725 st036284 20.55 µM 0.380376745505801 0.362245975549178 no 1219 0.351832887031959 1806 707914
SGTC_3331 9141060 1.957 µM 0.380279073663172 0.362280227478833 no 1220 0.351869133796461 1610 4906567 YPR165W RHO1
SGTC_342 k048-0088 23.3 µM 0.375024062611468 0.364124693634748 no 1221 0.353821285563001 1612 6820570
SGTC_1126 isoteolin 1.0172 µM 0.375021573094634 0.364125568185158 no 1222 0.353822211294595 1592 133323
SGTC_1204 4049-0315 18.3 µM 0.373650090152573 0.364607468308865 no 1223 0.354332331102124 1774 588402
SGTC_1718 roemerine 11.9335 µM 0.373120117896832 0.364793742871387 no 1224 0.354529523106639 1656 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.36827310734602 0.366498845293438 no 1225 0.356334801413892 1664 6857784
SGTC_2571 chrysanthemic acid 100 µM 0.367988018430573 0.366599217592858 no 1226 0.356441084113752 1590 2743 An insecticide.
SGTC_1498 4478-3555 97.6 µM 0.367621712392176 0.36672819769464 no 1227 0.356577661366255 1753 3437919
SGTC_873 0591-4978 488 µM 0.367391627638331 0.366809220585332 no 1228 0.356663457901563 1823 3305145
SGTC_1758 st042942 75.2445 µM 0.36705890277588 0.36692639803582 no 1229 0.35678754083681 1717 669317
SGTC_2220 6782180 200 µM 0.365622789185518 0.367432303785069 no 1230 0.357323283764275 1756 833803
SGTC_3085 9117376 49.47 µM 0.365585914079273 0.367445296967903 no 1231 0.357337043751329 1720 16480349
SGTC_1920 st075728 45.7 µM 0.364672425836013 0.367767218884531 no 1232 0.357677972083983 1826 3400306
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.36433993821924 0.367884413749157 no 1233 0.357802089956766 1716 6708739 YPR165W RHO1
SGTC_1628 st004252 77.7 µM 0.36334470049905 0.368235287504083 no 1234 0.358173702751456 1788 692968
SGTC_714 4296-0578 26.1 µM 0.361280618516523 0.36896333533174 no 1235 0.358944840428438 1788 1589775
SGTC_2882 9058044 58.44 µM 0.361004098360986 0.369060905956412 no 1236 0.359048191667605 1588 18076804
SGTC_1731 st035964 63 µM 0.360566249593533 0.369215418922175 no 1237 0.359211861643776 1650 6739575
SGTC_593 1203-0218 61.7 µM 0.360428743316259 0.369263948035393 no 1238 0.359263267485211 1784 3666956
SGTC_2202 7226349 200 µM 0.359697285597579 0.36952213121246 no 1239 0.35953676107343 1666 844334
SGTC_1632 st005650 90 µM 0.359329678965405 0.369651907826344 no 1240 0.359674237151193 1692 2759605
SGTC_2084 5306078 60.6385 µM 0.358382389791445 0.369986398875521 no 1241 0.360028584276279 1749 679340
SGTC_3130 9127414 49.47 µM 0.356100866871844 0.370792415780414 no 1242 0.360882514028663 1683 1494646
SGTC_1779 st039427 55 µM 0.354215936962919 0.371458752390808 no 1243 0.36158853045769 1879 1124498
SGTC_286 k060-0067 22.9 µM 0.353157573152467 0.371833060880588 no 1244 0.361985156423564 1691 5985051
SGTC_2113 5491891 107.031 µM 0.35300571039187 0.37188677969684 no 1245 0.36204207975872 1628 789979
SGTC_2992 9074591 71.4286 µM 0.352722376860107 0.37198701068389 no 1246 0.362148290973987 1707 17741321
SGTC_74 000s-0487 160.283 µM 0.351673992076253 0.372357958669483 no 1247 0.362541383729748 1657 677548
SGTC_889 0919-1524 82.7 µM 0.350115192424928 0.372909724691188 no 1248 0.363126124850328 1676 3905452
SGTC_2364 9055074 200 µM 0.3497171991679 0.373050643622309 no 1249 0.363275472357295 1641 6470630
SGTC_2774 tamoxifen 10.92 µM 0.347329202168136 0.37389652658466 no 1250 0.364172007296764 1698 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2974 9094440 9.66 µM 0.347038266757517 0.373999624145747 no 1251 0.364281285229319 1793 25236134
SGTC_2188 6126565 140.678 µM 0.34595032487222 0.374385233370944 no 1252 0.364690023606437 1771 874518
SGTC_125 0133-0007 11.75 µM 0.345254080617138 0.3746320755908 no 1253 0.364951682454255 1876 26541
SGTC_1320 1313-0481 95.3 µM 0.342616988530713 0.375567479327259 no 1254 0.365943309913851 1841 6813365 YLR208W SEC13
SGTC_692 k241-0027 77.8 µM 0.342323838519978 0.375671507960734 no 1255 0.366053598774702 1801 3600480
SGTC_3288 9119690 36.221 µM 0.339121848756168 0.376808368609238 no 1256 0.367258969865693 1671 17595618 YKL019W RAM2
SGTC_1045 1348-1485 165 µM 0.338678408891675 0.376965895625468 no 1257 0.367426003803207 1708 6810614
SGTC_795 0685-0265 78 µM 0.338259958225888 0.377114564294043 no 1258 0.367583647872492 1699 302754
SGTC_2702 st077768 96.8 µM 0.337581369471414 0.377355694483183 no 1259 0.36783934190466 1691 6484119
SGTC_2767 sibutramine 71.45 µM 0.337325118597285 0.37744676328685 no 1260 0.367935913152943 1845 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1772 st048439 82.2 µM 0.334991695904736 0.378276349583997 no 1261 0.368815675194534 1722 2927068 YDL195W SEC31
SGTC_2619 obliquin 87.91 µM 0.334184317482458 0.378563522415957 no 1262 0.36912023861982 1793 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2148 5546263 113.568 µM 0.332023666906811 0.379332364118042 no 1263 0.3699356940823 1737 792097
SGTC_1495 4469-0029 237 µM 0.329030092338906 0.380398380413049 no 1264 0.371066471420494 1699 793680
SGTC_2317 5986382 200 µM 0.326165834860559 0.381419197837968 no 1265 0.372149444483876 1850 877883
SGTC_987 1497-1013 404 µM 0.325004113922436 0.38183346929245 no 1266 0.37258897905792 1763 1676435
SGTC_599 1935-0052 86.5 µM 0.322942693916361 0.382568907742447 no 1267 0.373369321048256 1746 9557311
SGTC_877 0771-0151 33.1 µM 0.321865347488846 0.382953433877671 no 1268 0.373777353019543 1773 6166523
SGTC_1896 st058441 89 µM 0.321603873958253 0.383046776338728 no 1269 0.373876404323858 1693 688759
SGTC_2371 9071574 200 µM 0.321520471191889 0.383076551410306 no 1270 0.373908000680878 1831 45596039
SGTC_3229 9132204 49.47 µM 0.321391338321831 0.383122653647402 no 1271 0.373956923130888 1796 17682924
SGTC_1102 cgs 12066b 26.1 µM 0.319582810255824 0.383768497080145 no 1272 0.37464230347588 1772 6438352 A 5-HT1B full agonist.
SGTC_1937 st074714 47.2 µM 0.31791887432795 0.384362990575483 no 1273 0.37527323758187 1652 17250970
SGTC_1955 wogonin 32.4 µM 0.317896074886969 0.384371138286447 no 1274 0.375281885035529 1848 5281703 A flavanone.
SGTC_2076 5212012 200 µM 0.31722545197478 0.38461081794915 no 1275 0.37553626931394 1756 604802
SGTC_2244 6635614 200 µM 0.316387752437953 0.384910272515093 no 1276 0.375854106010212 1753 836499
SGTC_564 3555-0129 330 µM 0.316335922538806 0.384928802537196 no 1277 0.375873773878385 1843 563260
SGTC_2490 carminic acid 95.39 µM 0.315698783698091 0.38515661137545 no 1278 0.376115574995934 1765 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_365 0121-0052 13.6 µM 0.313535650109626 0.385930334581322 no 1279 0.376936870091618 1803 3101739
SGTC_1685 st024049 53.0905 µM 0.312253198411715 0.386389264526572 no 1280 0.377424052621964 1792 1941139
SGTC_2797 7859098 81.82 µM 0.308567837316728 0.387708966995103 no 1281 0.37882514488729 1741 972681
SGTC_2991 9074669 71.4286 µM 0.306733423300434 0.388366342965362 no 1282 0.379523143598956 1834 17333109
SGTC_1668 st014914 51.6 µM 0.306096986636389 0.388594489645702 no 1283 0.379765401101132 1783 2839556
SGTC_950 1165-0508 94.1 µM 0.30570009161052 0.388736786083133 no 1284 0.379916501775146 1709 6148369
SGTC_2376 9072922 81.32 µM 0.304997192062558 0.388988829143151 no 1285 0.380184145454888 1798 17087968
SGTC_400 oxethazaine 37.5 µM 0.304960127276786 0.38900212099159 no 1286 0.380198260239804 1762 4621 A local anesthetic.
SGTC_3136 9095672 49.47 µM 0.3044369310536 0.389189758885867 no 1287 0.380397517636774 1914 17217380
SGTC_3163 9099914 49.47 µM 0.304052299305482 0.389327718820327 no 1288 0.380544023499524 1831 16268368
SGTC_187 1488-2104 32.728 µM 0.303906168854521 0.38938013663165 no 1289 0.380599688940278 1845 2852859
SGTC_586 0957-0265 8.15 µM 0.303838890753551 0.389404270340065 no 1290 0.380625318003737 1868 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_362 0310-0100 9.03 µM 0.303586299377593 0.389494882628705 no 1291 0.380721545376988 1749 790235
SGTC_2696 st077691 74.316 µM 0.300548428549691 0.390585129554058 no 1292 0.381879431060809 1788 757133
SGTC_2103 5378138 10 µM 0.300288416330447 0.390678484207017 no 1293 0.381978584097026 1831 244142
SGTC_386 1509-0011 3.07 µM 0.299485900149307 0.390966658921021 no 1294 0.382284664342214 1763 3107280
SGTC_3293 9120939 62.045 µM 0.296654113635026 0.3919839996854 no 1295 0.383365296377117 1837 934087
SGTC_1581 himbacine 57.9 µM 0.296568633190217 0.392014720706737 no 1296 0.383397930548692 1743 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1170 0310-0127 64.8 µM 0.294857584833246 0.392629799827636 no 1297 0.384051337259656 1825 774975
SGTC_2752 diclazuril 33.15 µM 0.294541482732698 0.392743460035042 no 1298 0.384172084908345 1897 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2999 9069765 71.4286 µM 0.292862734451318 0.393347237295375 no 1299 0.384813537076832 1846 2097066
SGTC_2075 5212009 200 µM 0.292816668290122 0.393363809037604 no 1300 0.384831143478576 1884 780898
SGTC_70 0141-0289 43.283 µM 0.292021323321343 0.393649955172379 no 1301 0.38513516027512 1849 352408
SGTC_1717 st033143 58.0435 µM 0.291746380693755 0.393748886335191 no 1302 0.385240272209213 1905 674616
SGTC_2835 9006588 71.43 µM 0.291255656984852 0.393925477912672 no 1303 0.385427899273867 1754 2345538
SGTC_2788 5282734 71.43 µM 0.290376397271867 0.394241942388269 no 1304 0.385764149221333 1913 743706
SGTC_1750 st081859 2.357 µM 0.2901658506988 0.394317732997346 no 1305 0.385844680018178 1828 5291695
SGTC_690 glyoxal 20.3 µM 0.289313506370305 0.394624592889346 no 1306 0.386170738737257 1809 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_25 0118-0223 35.662 µM 0.288456948326212 0.394933035679279 no 1307 0.38649849039674 1874 5333628
SGTC_3061 glucosamine 200 µM 0.287019880148699 0.395450665463838 no 1308 0.387048549107655 1936 91431 and experimental redox chemotherapeutic
SGTC_1901 st060216 58.6 µM 0.286515875265745 0.395632251008675 no 1309 0.387241518098281 1749 688792
SGTC_2030 5175110 200 µM 0.286179928556541 0.395753300252944 no 1310 0.387370157923383 1856 2831986
SGTC_1033 k072-0102 21.3 µM 0.28506411638889 0.396155424872154 no 1311 0.387797510453259 1920 5965931
SGTC_715 0868-0130 184 µM 0.28493693284028 0.396201267242024 no 1312 0.387846229990468 1953 2876258
SGTC_2614 arthonioic acid 13.39 µM 0.284644178563793 0.396306793810173 no 1313 0.387958380549268 1776 6710684
SGTC_1821 st053465 65.6 µM 0.283868236804436 0.396586527471231 no 1314 0.388255679473912 1796 675086
SGTC_872 0588-0139 234 µM 0.283834706860266 0.396598616504675 no 1315 0.388268527812794 1779 2047100
SGTC_191 3914-0123 66.505 µM 0.282812231362378 0.396967311992581 no 1316 0.388660388841114 1777 3144412
SGTC_1820 st053765 18.6 µM 0.282238336930093 0.397174293555205 no 1317 0.388880382043933 1758 3690829
SGTC_317 4495-0002 170 µM 0.281913441814382 0.397291483522175 no 1318 0.389004941164654 1774 15991618
SGTC_236 1509-0011 5.31 µM 0.281705427010755 0.397366519522724 no 1319 0.389084696403864 1891 3107280
SGTC_1053 3366-3204 134 µM 0.279480092992142 0.398169488785348 no 1320 0.389938206552077 1740 3632071 YPR165W RHO1
SGTC_537 1334-0398 209 µM 0.278310767223375 0.398591590781102 no 1321 0.390386905729378 1958 5846986
SGTC_2170 morpholine 200 µM 0.277208296130415 0.398989668333507 no 1322 0.390810084886545 1900 121171 Reacts with secondary amines.
SGTC_199 4063-0024 41.6 µM 0.275278717508225 0.399686648518675 no 1323 0.39155105701677 1908 306215
SGTC_1993 st073995 70.8 µM 0.275167793903031 0.399726724807193 no 1324 0.39159366447309 1849 3098394
SGTC_614 0462-0418 107 µM 0.271818810775371 0.400937195595385 no 1325 0.392880670352609 1855 5188303
SGTC_1471 k673-0312 37 µM 0.270028203467488 0.401584791572195 no 1326 0.393569278022407 1937 24099884
SGTC_82 0054-0107 293.755 µM 0.269702639443469 0.401702565055536 no 1327 0.393694514895212 1961 3104697
SGTC_1958 st076513 41.9 µM 0.268046097749514 0.402301960640004 no 1328 0.394331917850861 1812 732122 YGL099W LSG1
SGTC_3201 9113999 49.47 µM 0.268008958554441 0.402315401557947 no 1329 0.394346211494986 1880 16649224
SGTC_2659 sanguinarine 24.21 µM 0.267596559894011 0.402464659092384 no 1330 0.394504939615574 1845 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3222 9128301 49.47 µM 0.26729211620834 0.402574854108229 no 1331 0.394622128186647 1808 4911358
SGTC_3279 9140807 49.47 µM 0.265794225913306 0.403117136070129 no 1332 0.39519884518537 1840 45595718
SGTC_2795 7780010 54.55 µM 0.265293988663598 0.403298278775872 no 1333 0.395391497503902 1839 953673
SGTC_1865 st057639 52.2 µM 0.264780712780835 0.403484164516972 no 1334 0.395589197862047 1889 688818
SGTC_3317 9138495 8.753 µM 0.264631094909953 0.403538353574995 no 1335 0.395646831787296 1847 17020139
SGTC_566 0958-0068 16.5 µM 0.263885929650332 0.403808267367809 no 1336 0.395933908991389 1891 6815365
SGTC_730 1436-0052 41.2 µM 0.263456786857503 0.403963732286167 no 1337 0.396099263198212 1865 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_42 0133-0086 60.653 µM 0.260771027789022 0.40493704185524 no 1338 0.397134544037026 1774 162923 Model of phenazepam hydroxylation.
SGTC_1956 st077085 54 µM 0.260697888205285 0.404963555637893 no 1339 0.397162747364293 1815 24208685
SGTC_1774 st048371 48.465 µM 0.260555840235825 0.405015050600708 no 1340 0.397217523964459 1781 4242727
SGTC_2193 5925765 200 µM 0.257337523585939 0.406182187809473 no 1341 0.398459113963419 1932 877370
SGTC_107 0358-0022 2.6945 µM 0.257151854461136 0.406249547114075 no 1342 0.398530774502967 1945 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1948 st076329 66.6 µM 0.256810318279401 0.406373461011857 no 1343 0.398662602160626 1935 24208413
SGTC_3115 9123671 49.47 µM 0.255683101815705 0.406782496714465 no 1344 0.399097772176333 1980 3286988
SGTC_1216 1165-0504 9.65 µM 0.253312810865923 0.407642941105282 no 1345 0.400013248619972 1978 6304004
SGTC_2098 5376439 882.5 nM 0.252086997411265 0.408088101399861 no 1346 0.400486910026693 1945 2844116
SGTC_636 0kpi-0074 126 µM 0.251862570531064 0.408169616013536 no 1347 0.400573645744793 1853 616434
SGTC_3182 9108849 49.47 µM 0.251470211234172 0.408312135299974 no 1348 0.40072529517371 1877 17133045
SGTC_2962 9082311 13.18 µM 0.251138032290529 0.408432804356985 no 1349 0.400853696201045 1799 16459453
SGTC_2175 5807670 165.306 µM 0.249430971209522 0.40905305699771 no 1350 0.401513715246855 1971 241186
SGTC_2336 9001819 198.65 µM 0.248382106811697 0.409434270040615 no 1351 0.401919388290203 1928 2989602
SGTC_2206 7254556 146.969 µM 0.241761330097825 0.411842574598194 no 1352 0.404482552123729 1980 4398905
SGTC_818 4072-2707 53.5 µM 0.240690684916255 0.412232335948333 no 1353 0.404897429562203 1845 882871
SGTC_545 4218-0007 221 µM 0.240003267362236 0.412482631462806 no 1354 0.40516386181881 1894 2840508
SGTC_2987 9018338 71.43 µM 0.238212542321544 0.413134819011103 no 1355 0.40585812486184 1889 5055682
SGTC_2399 5884133 200 µM 0.235914500041048 0.413972124153832 no 1356 0.406749508192042 1837 722445
SGTC_2435 5706476 10.6 µM 0.235541676855059 0.414108001445015 no 1357 0.406894167571325 2013 5725375
SGTC_1817 st052116 64.4 µM 0.234944772925952 0.414325567496174 no 1358 0.407125799116772 1981 4361398
SGTC_1285 0929-0069 65.5 µM 0.233862504557927 0.414720111476057 no 1359 0.407545861547993 1901 1206237
SGTC_256 clotrimazole 625 nM 0.22921777184656 0.416414334121975 no 1360 0.409349830165806 1921 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_359 0081-0058 15.9 µM 0.229032813399512 0.416481832343382 no 1361 0.409421706240759 2000 3494159
SGTC_465 cgp-37157 41 µM 0.228685984448456 0.416608409773975 no 1362 0.409556494469635 2021 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2905 7799065 20.05 µM 0.228600802910538 0.416639498640929 no 1363 0.409589600229624 2009 1296806
SGTC_2921 7974240 10.71 µM 0.228185123079281 0.416791217571927 no 1364 0.409751163222395 1940 2979074 YDR527W RBA50
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.227836235676388 0.416918567510834 no 1365 0.409886777717977 1954 688761
SGTC_2240 6690706 185.951 µM 0.227355310683318 0.41709412774438 no 1366 0.410073733636278 1791 805876
SGTC_986 1493-0483 84 µM 0.224915109725679 0.417985169868668 no 1367 0.411022657283477 2027 40079
SGTC_1714 st033236 13.627 µM 0.224808286882929 0.41802418600483 no 1368 0.411064209541383 1967 2916566
SGTC_3169 9102970 49.47 µM 0.222585954115925 0.41883605659731 no 1369 0.411928884606907 1964 17027839
SGTC_1809 st050081 57.6 µM 0.221412421732318 0.419264915400267 no 1370 0.412385660646016 1996 5036894
SGTC_477 mead ethanolamide 10 µM 0.220989492007792 0.419419495509609 no 1371 0.412550307443374 1990 16061185
SGTC_768 0384-0033 77.3 µM 0.220510136890178 0.419594714041581 no 1372 0.412736939284641 1844 3965305 YMR134W ERG29
SGTC_1357 1503-1303 39.5 µM 0.219910130198216 0.419814056770878 no 1373 0.412970573336317 1901 292895
SGTC_1428 4049-0204 61.7 µM 0.219569092444093 0.419938740075287 no 1374 0.413103382322374 2013 X1428
SGTC_3137 9097352 49.47 µM 0.219236203046139 0.420060452093752 no 1375 0.41323302771807 1989 44120435
SGTC_3155 9099265 49.47 µM 0.219087313097237 0.420114892157915 no 1376 0.413291016696353 1952 25236499
SGTC_3255 9139072 49.47 µM 0.218614178548286 0.420287899034949 no 1377 0.413475303533284 1920 17646060
SGTC_1553 gossypol 38.6 µM 0.218142218522308 0.420460491779403 no 1378 0.413659151882812 1996 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_840 0245-0196 390 µM 0.216410677916622 0.42109383577144 no 1379 0.41433382185082 2013 3827528
SGTC_1575 cyproterone acetate 48 µM 0.216312055860298 0.421129914832276 no 1380 0.414372256150334 1866 9880 An androgen receptor antagonist and liver toxin.
SGTC_1138 3761-0006 1.03 µM 0.216062809708432 0.421221099892594 no 1381 0.41446939427499 2018 12061087
SGTC_179 1273-0063 6.77 µM 0.215547317473058 0.42140970272786 no 1382 0.414670312459816 1884 3108139
SGTC_2058 5236698 133 µM 0.214537936556556 0.421779056504886 no 1383 0.415063793242011 1911 766665
SGTC_2231 micatex 6.853 µM 0.214397269490564 0.421830535023792 no 1384 0.415118635397217 1973 20737 An antifungal of unknown mechanism.
SGTC_2784 7567673 72.73 µM 0.214389591609019 0.421833344859743 no 1385 0.415121628836128 1958 3471247
SGTC_2373 9071805 200 µM 0.213997278445037 0.421976923041811 no 1386 0.415274589754828 2079 10149009
SGTC_529 4076-0302 30.3 µM 0.213742214393085 0.422070276564625 no 1387 0.415374044829138 1894 5816522
SGTC_2044 5102272 200 µM 0.213674381081878 0.422095104315061 no 1388 0.415400495439613 1939 592666
SGTC_3247 9135149 49.47 µM 0.21321667453888 0.422262638115621 no 1389 0.415578981446389 1953 8934436 YOR116C RPO31
SGTC_1522 st012842 45.6 µM 0.212765077926555 0.42242794929126 no 1390 0.415755101913437 1832 3491067 YOR116C RPO31
SGTC_1649 st011737 51.3 µM 0.212349054832715 0.422580250540093 no 1391 0.415917363859347 1915 1761035
SGTC_110 0850-0284 111.64 µM 0.211496056946407 0.422892559384203 no 1392 0.416250104364546 2038 3906265
SGTC_1683 st010134 710 nM 0.211244449563615 0.422984689875426 no 1393 0.416348263759848 1846 3818134
SGTC_947 3447-0010 211 µM 0.210605152109326 0.423218798876598 no 1394 0.416597695841538 1986 748350
SGTC_3004 9076122 71.4286 µM 0.209424803132256 0.423651110666284 no 1395 0.417058315968135 2017 44782551
SGTC_2957 9076800 11.52 µM 0.208079857159782 0.424143819366323 no 1396 0.417583307298625 1896 16459615
SGTC_1455 4262-0120 131 µM 0.207788102837887 0.424250716581977 no 1397 0.417697211217727 2001 1529587
SGTC_2091 4-phenylthiadiazole 200 µM 0.207509009437336 0.424352980119484 no 1398 0.417806178644112 1920 270010
SGTC_2171 5739187 198.077 µM 0.206525221750397 0.424713493596252 no 1399 0.418190332636325 1899 2262761
SGTC_3306 9127676 59.7925 µM 0.205317786722429 0.425156049720828 no 1400 0.418661924140066 1899 41905287
SGTC_659 k018-0002 107 µM 0.20519407456589 0.425201398758615 no 1401 0.418710249381281 2070 6797879 YHR007C ERG11
SGTC_355 1311-2252 105 µM 0.204967862129997 0.425284323777257 no 1402 0.41879861711524 1909 5338538
SGTC_2286 7945697 125 µM 0.204944753056957 0.425292795293932 no 1403 0.418807644685305 1877 1245733
SGTC_2327 6189656 200 µM 0.204305750586989 0.425527059797684 no 1404 0.419057288216069 2011 5349088
SGTC_3314 9135860 59.4275 µM 0.203413577063883 0.425854183230121 no 1405 0.41940589433996 2069 25252478
SGTC_1847 st056231 15 µM 0.202889819227481 0.426046247532015 no 1406 0.419610575936245 1977 5393180
SGTC_2937 9044753 11.33 µM 0.202186559769773 0.426304163453367 no 1407 0.41988543995106 1955 6465530 YGL099W LSG1
SGTC_909 3448-9333 149 µM 0.200961298876282 0.426753595311728 no 1408 0.420364417850253 1886 3344074
SGTC_3094 9117742 49.47 µM 0.200904740847342 0.426774343382187 no 1409 0.420386530317967 2053 17149698
SGTC_1868 st057644 42.7 µM 0.19990950222423 0.427139475505332 no 1410 0.420775679375144 2000 688665
SGTC_2063 5246145 200 µM 0.199829662115311 0.427168769871601 no 1411 0.420806901080513 1991 711240
SGTC_507 nimesulide 162 µM 0.198148862316693 0.427785569989203 no 1412 0.421464298029522 2051 4495 A COX2 inhibitor.
SGTC_1229 0139-0193 12.2 µM 0.197130303999832 0.428159434519393 no 1413 0.421862784766162 2090 3090752
SGTC_995 3931-2021 34.6 µM 0.196948259329836 0.428226261301383 no 1414 0.421934013857609 1961 730143
SGTC_297 0986-0032 24 µM 0.194160115729859 0.429250017062944 no 1415 0.423025255787839 1953 2847425
SGTC_618 k072-0232 33.2 µM 0.193827859443599 0.429372047425602 no 1416 0.423155335996051 1974 5872756 YGL099W LSG1
SGTC_2884 9058502 51.95 µM 0.193487087768841 0.429497212312795 no 1417 0.423288758729033 1961 6471554
SGTC_295 k015-0027 31 µM 0.19064127830879 0.430542749111334 no 1418 0.424403323918147 2003 3887424
SGTC_1451 4152-0210 104 µM 0.190386711749202 0.430636299491629 no 1419 0.424503054862717 2061 659563
SGTC_642 0335-0876 158 µM 0.190336142095746 0.430654883740645 no 1420 0.424522866993037 1959 6812350
SGTC_921 1561-0023 372 µM 0.190306131060376 0.430665912810229 no 1421 0.424534624777855 1929 24050882
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.18996869772421 0.430789923440066 no 1422 0.42466682972024 1935 5282362
SGTC_2493 resveratrol 26.09 µM 0.188316923941167 0.431397067540205 no 1423 0.425314109654047 1960 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2046 4110841 106 µM 0.187598816411076 0.431661073672924 no 1424 0.425595577069268 2111 44119630 YMR134W ERG29
SGTC_2355 9061122 103.12 µM 0.187431732625373 0.431722504989396 no 1425 0.425661072204851 2065 5302957
SGTC_1161 k007-0610 110 µM 0.183613348059877 0.433126848947684 no 1426 0.427158395461268 2098 5843850
SGTC_893 0958-0369 48.9 µM 0.182957048256221 0.433368311649302 no 1427 0.427415860108875 2111 6819948
SGTC_589 1227-0070 34.1 µM 0.182929638891495 0.433378396514111 no 1428 0.427426613402234 2010 2841384
SGTC_3164 9100705 49.47 µM 0.182917448353457 0.43338288185375 no 1429 0.427431396034296 2073 17174235
SGTC_2021 4019055 173 µM 0.182720354676762 0.433455400932843 no 1430 0.427508721954718 2024 44827708 YER133W GLC7
SGTC_2952 9073731 13.78 µM 0.182695298989401 0.433464620137894 no 1431 0.427518552272229 1943 16457353
SGTC_1057 3448-5381 134 µM 0.180539448005196 0.434257997532454 no 1432 0.428364544064036 2068 5497911
SGTC_518 1021-0119 62.6 µM 0.179844380988518 0.434513846626446 no 1433 0.428637370315783 1900 1097762
SGTC_1568 digitonin 820 nM 0.179603800023785 0.434602409118397 no 1434 0.428731810605004 2127 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_954 1189-0853 2.85 µM 0.179232538154425 0.434739084209353 no 1435 0.428877557814976 2089 2828194
SGTC_87 0100-0052 35.5 µM 0.178384774048603 0.435051206436951 no 1436 0.429210403039281 2006 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_251 melphalan 456.522 µM 0.177055170973074 0.435540809287151 no 1437 0.429732526950939 2039 460612 A DNA alkylator.
SGTC_265 mycophenolic acid 32.932 µM 0.176943486140867 0.435581939763552 no 1438 0.429776390251465 2078 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3342 9147791 14.508 µM 0.175994327722768 0.435931516993086 no 1439 0.430149199357719 2040 1838168
SGTC_3079 9117512 49.47 µM 0.174636675877751 0.43643163023992 no 1440 0.430682564111779 2060 7185044
SGTC_689 0833-0039 98 µM 0.174338945686622 0.436541317637814 no 1441 0.430799546821375 2083 5374726
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.174167765701129 0.43660438462153 no 1442 0.430866808784927 1955 61125 An anti-inflammatory.
SGTC_1730 st033808 45.1 µM 0.172340896941841 0.437277548771246 no 1443 0.431584767106955 1941 1045166
SGTC_2807 7945238 51.95 µM 0.171925193593413 0.437430752473964 no 1444 0.431748169931494 1998 17148797
SGTC_1766 st045414 44.774 µM 0.171770769888095 0.437487666322519 no 1445 0.431808873091679 2048 253960
SGTC_3256 9138902 49.47 µM 0.171478921630169 0.437595232404041 no 1446 0.431923601529097 2094 17228773
SGTC_1144 3486-0183 12.5 µM 0.171426209552728 0.437614660908567 no 1447 0.431944323780673 2005 6744069
SGTC_1331 1472-0049 76.2 µM 0.170167477865634 0.438078646111535 no 1448 0.432439213781457 1960 24051409
SGTC_3287 9117173 37.0625 µM 0.170148898952921 0.438085495184456 no 1449 0.432446519166656 2141 2789709
SGTC_1578 josamycin 24.2 µM 0.169991010734071 0.438143701057109 no 1450 0.432508603077953 1934 5282165 A P450 substrate.
SGTC_1653 st012112 65 µM 0.169830754296822 0.43820278134764 no 1451 0.432571619910677 2087 720429
SGTC_1070 indatraline 8.81 µM 0.167028392792823 0.439236124083156 no 1452 0.433673854257726 1996 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_638 3970-0837 4.09 µM 0.166737238175296 0.439343508305775 no 1453 0.433788401918087 1967 4118451 YLR208W SEC13
SGTC_2759 disulfiram 3.38 µM 0.166217492803446 0.439535212914357 no 1454 0.433992896835484 2012 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2066 5222451 176 µM 0.166012536751266 0.439610813485997 no 1455 0.434073542088404 2091 2281147
SGTC_47 0149-0135 24.25 µM 0.165649592249137 0.439744695450432 no 1456 0.434216358707929 2007 5239155
SGTC_656 4090-1979 187 µM 0.164682845498071 0.44010133990208 no 1457 0.434596809961959 2121 22330961
SGTC_846 0335-0850 148 µM 0.164560517662148 0.440146471575742 no 1458 0.434644954896813 2104 6819598
SGTC_3101 9120531 49.47 µM 0.164277434705252 0.440250915279968 no 1459 0.434756372424173 2115 24824904
SGTC_1074 carmofur 3.8 µM 0.160914565182829 0.441491964993006 no 1460 0.436080345222832 2122 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1056 3448-1962 115 µM 0.159736021269108 0.441927037180553 no 1461 0.436544512173346 2034 715507
SGTC_336 4111-0029 111 µM 0.159421958722136 0.442042988599901 no 1462 0.436668219795556 2004 3131175
SGTC_1184 1269-1718 139 µM 0.158422918567298 0.442411865696963 no 1463 0.437061777707483 2116 5403821
SGTC_2267 7931562 200 µM 0.156899675121747 0.442974391167867 no 1464 0.437661957951286 1881 934880
SGTC_2946 9065502 71.43 µM 0.156037953320357 0.443292671302854 no 1465 0.438001552592315 2150 16489101
SGTC_1550 gossypolone 36.6 µM 0.155150889900054 0.443620349677518 no 1466 0.438351181770636 2142 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_244 nsc-207895 1.295 µM 0.155002482387049 0.443675174706169 no 1467 0.438409680148953 2042 42640
SGTC_1898 st060199 18.6 µM 0.154495942867164 0.443862309758831 no 1468 0.438609354968894 1990 688866
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.15413115313276 0.443997084780836 no 1469 0.438753162561448 2121 165506
SGTC_555 4296-0685 37 µM 0.153740812511565 0.444141306992891 no 1470 0.438907051792206 2131 2908540 YHR072W ERG7
SGTC_164 4100-3994 89.624 µM 0.153182846712319 0.444347475834258 no 1471 0.439127042180623 2150 4615967
SGTC_1726 st035556 14.5795 µM 0.152389959090848 0.444640474382305 no 1472 0.439439688035907 2109 5919439
SGTC_2820 7989630 71.43 µM 0.151673269437947 0.444905341262701 no 1473 0.439722320558122 2157 2984098
SGTC_2243 6634756 200 µM 0.151639152326753 0.44491795053236 no 1474 0.439735775691763 2128 885676
SGTC_2654 protoveratrine a 100 µM 0.150803677102068 0.445226749384769 no 1475 0.440065292767098 2114 5702278 A heart drug and vasodilator.
SGTC_3322 9139058 2.11 µM 0.149514475303279 0.445703314644413 no 1476 0.440573844054324 2095 4908926 YPR165W RHO1
SGTC_744 1594-0068 283 µM 0.149130099960894 0.445845417727342 no 1477 0.440725487561291 2041 668392
SGTC_291 SEC14.278 35.5 µM 0.148209272958158 0.446185874579447 no 1478 0.441088806939307 2123 1068044
SGTC_3098 9119039 49.47 µM 0.14760412833371 0.446409635983774 no 1479 0.441327598426822 2175 17161528
SGTC_702 1488-0190 94 µM 0.14724453275726 0.44654260999091 no 1480 0.441469505793319 2177 949357
SGTC_2634 4'-methoxyflavone 100 µM 0.145875368750551 0.447048964837457 no 1481 0.44200988822692 2014 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2949 9072542 2.23 µM 0.144965197507588 0.447385619242815 no 1482 0.442369174922432 2038 16457352
SGTC_2177 5811945 192 µM 0.144347434589201 0.447614139184369 no 1483 0.442613061551656 2108 5343475
SGTC_1824 st053723 68.6 µM 0.143898579693025 0.447780188380028 no 1484 0.442790278628219 1998 675225
SGTC_794 k038-0031 316 µM 0.143733821129534 0.447841141392913 no 1485 0.442855331546538 2136 6624242
SGTC_1098 clofazimine 15.1 µM 0.143328273991909 0.44799118023383 no 1486 0.443015463469139 2125 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_403 arphamenine a 50 µM 0.142781116038406 0.448193622115909 no 1487 0.443231525739683 2064 5487158 An arginine aminopeptidase inhibitor.
SGTC_1917 st066507 28.5 µM 0.142719078099528 0.448216576262047 no 1488 0.443256024408616 2010 3156428
SGTC_2011 4012611 177 µM 0.142559353495638 0.448275675443142 no 1489 0.44331910036136 2040 2049887
SGTC_1615 st002656 86.5 µM 0.14253309868345 0.448285390010685 no 1490 0.443329468640341 2168 1584458
SGTC_2931 9014674 55.67 µM 0.141832535388538 0.448544617524622 no 1491 0.443606142161887 2090 2996810
SGTC_1872 amphotericin b 148 nM 0.140611612515787 0.448996444711972 no 1492 0.44408838696417 2134 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_7 0192-1582 4.227 µM 0.140290720033309 0.449115208463089 no 1493 0.444215148077658 2102 252616
SGTC_944 3370-0224 231 µM 0.139639037281267 0.449356413200998 no 1494 0.444472597744573 2035 4580514
SGTC_2770 toltrazuril 17.5 µM 0.137533323347521 0.450135920189558 no 1495 0.445304627388947 2164 68591 Kills coccidiodes.
SGTC_1626 st003712 1.76 µM 0.137123802828507 0.450287541623295 no 1496 0.445466469122179 2100 24207035
SGTC_3289 9119912 71.43 µM 0.13638572211395 0.450560827939674 no 1497 0.445758180155373 2100 17014829
SGTC_1135 dihydrocapsaicin 536.708 nM 0.135611027774321 0.450847696255373 no 1498 0.446064393546132 2050 107982 A Capsaicinoid.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.135185612110081 0.451005238058776 no 1499 0.446232561268925 2159 1377
SGTC_2667 digitoxin 100 µM 0.13395612599734 0.4514605900748 no 1500 0.446718634022834 2194 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_290 2043-6722 48.1 µM 0.133390455176787 0.451670113198639 no 1501 0.446942296809136 2139 773758 YLR208W SEC13
SGTC_2616 abietic acid 100 µM 0.133250336106011 0.451722015051284 no 1502 0.44699770164438 2201 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2186 6124449 200 µM 0.13294545830286 0.451834948444718 no 1503 0.447118257718344 2135 3834182 YLR033W RSC58
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.132600763077822 0.451962635774455 no 1504 0.447254564451006 2106 23665772 A membrane-active detergent.
SGTC_2108 5365811 200 µM 0.131977848487235 0.452193398014536 no 1505 0.447500906407153 2128 780283
SGTC_1798 st045719 60.953 µM 0.131909742528488 0.452218629233769 no 1506 0.44752784127348 2166 3980186
SGTC_2818 7996756 12.99 µM 0.129563949685018 0.453087792370877 no 1507 0.4484557133765 2116 2241621
SGTC_3063 1327-0034 4 µM 0.129452054959497 0.453129257253328 no 1508 0.448499980124402 2156 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2780 5215298 71.43 µM 0.129255659474626 0.453202036858364 no 1509 0.448577677824815 2214 2834131
SGTC_2917 7979103 53.79 µM 0.128602683540029 0.453444025861203 no 1510 0.448836021393002 2132 2980565
SGTC_169 k015-0017 16.025 µM 0.127932882891432 0.453692267963935 no 1511 0.44910104403531 2158 1840002
SGTC_2146 5545642 200 µM 0.127775858340346 0.453750467162214 no 1512 0.449163177844066 2166 825326
SGTC_2003 4023581 200 µM 0.127247694873218 0.453946231668552 no 1513 0.449372178556639 2075 16641307
SGTC_1196 1588-0294 184 µM 0.126918509970533 0.454068250163106 no 1514 0.449502448138775 2047 6144269
SGTC_2930 9013230 14.89 µM 0.126426160110723 0.454250756865218 no 1515 0.449697297757999 2139 2995857
SGTC_2126 5251174 33.877 µM 0.12590204855054 0.454445047766595 no 1516 0.449904730536404 2192 790722
SGTC_2418 pentamidine 31.67 µM 0.123946368346829 0.455170124515527 no 1517 0.450678869675096 2202 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2017 5132927 60.65 µM 0.122594589722063 0.455671389638271 no 1518 0.451214069451178 2107 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3320 9137005 35.139 µM 0.122390196473104 0.455747188688901 no 1519 0.451295001111684 2025 4908713
SGTC_2838 9002687 71.43 µM 0.12059411483602 0.456413332893901 no 1520 0.452006265251303 2029 6457060
SGTC_1588 farnesol 29.9 µM 0.119689136673579 0.456749024507302 no 1521 0.452364703086166 2102 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1346 1488-2224 62.4 µM 0.118168110136099 0.4573133018521 no 1522 0.452967228655098 2205 3722427
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.117862501435235 0.457426688378603 no 1523 0.453088302807185 2191 688798
SGTC_2440 5628896 157.78 µM 0.117267849370869 0.457647325306194 no 1524 0.453323900847941 2112 5522048
SGTC_3103 9120822 49.47 µM 0.117082163281571 0.457716224083996 no 1525 0.453397472076304 2192 17141819
SGTC_1606 st000094 49.2 µM 0.116984091724928 0.457752614023922 no 1526 0.453436329940152 2210 1242210
SGTC_1071 trifluoperazine 6.31 µM 0.116665153552962 0.457870960069526 no 1527 0.45356270254597 2157 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2225 6654152 15.4 µM 0.115503375901846 0.458302083878904 no 1528 0.454023072402337 2176 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2151 5563267 85.4165 µM 0.113811991231312 0.458929827005188 no 1529 0.45469341636723 2072 5310824
SGTC_205 1486-1330 71.903 µM 0.112233626826294 0.45951571603676 no 1530 0.455319083623193 2131 4118834
SGTC_3351 9150312 21.596 µM 0.111483368309614 0.459794242987063 no 1531 0.455616526774279 2206 4904905
SGTC_878 0828-0289 13.7 µM 0.110171692587592 0.460281238517534 no 1532 0.456136605814837 2065 745350 YLR208W SEC13
SGTC_1187 1391-0724 117 µM 0.109821935514169 0.460411105501603 no 1533 0.456275297121734 2099 6997986
SGTC_2496 diffractaic acid 79.83 µM 0.108095485040798 0.461052208942904 no 1534 0.456959974792628 2217 94870 An apoptosis inducer which activates caspases.
SGTC_3048 9093155 49.47 µM 0.107970437496417 0.461098648290591 no 1535 0.457009571275721 2239 25236002
SGTC_2408 sulbentine 18.36 µM 0.106629888646883 0.461596525845069 no 1536 0.457541303023445 2086 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2744 captopril 92.04 µM 0.106452829932768 0.461662289666119 no 1537 0.457611539468077 2220 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2888 9058547 12.99 µM 0.103065465995594 0.462920637045655 no 1538 0.458955506582894 2163 16476514
SGTC_2032 5185112 25.99 µM 0.102856879511405 0.462998135592151 no 1539 0.459038280641543 2199 5718189
SGTC_3188 9110789 49.47 µM 0.102196680350321 0.463243436257785 no 1540 0.459300281328896 2202 849217
SGTC_1664 st014217 9.02 µM 0.101776383394659 0.463399607213382 no 1541 0.459467085806198 2232 3982782
SGTC_2600 tangeritin 87.95 µM 0.101550986978254 0.46348336073692 no 1542 0.459556542479861 2190 68077 A bioactive flavone.
SGTC_2475 5812728 15.03 µM 0.101443994849827 0.463523117781974 no 1543 0.45959900687068 2241 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1839 st053978 48 µM 0.100938660258964 0.46371089922415 no 1544 0.459799576683533 2232 3788398
SGTC_970 1315-0089 19.5 µM 0.100932249270767 0.463713281588074 no 1545 0.459802121302468 2225 6811083 YLR033W RSC58
SGTC_2028 5153890 36.43 µM 0.100151603484847 0.464003384219585 no 1546 0.460111983789853 2182 2830968 YPR165W RHO1
SGTC_1270 0831-1170 17.3 µM 0.0981235144167025 0.464757149268233 no 1547 0.460917107910161 2224 6764716
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0955516163973445 0.465713209385708 no 1548 0.46193834690605 2161 6708760
SGTC_733 4069-0007 56.1 µM 0.0954987406738777 0.465732867147722 no 1549 0.461959345243313 2225 5717425 YNL287W SEC21
SGTC_1651 st011928 86.1 µM 0.0949715053787327 0.465928883517586 no 1550 0.462168730004113 2192 720198
SGTC_1300 1094-0077 113 µM 0.0939848266927095 0.466295734647992 no 1551 0.462560604962431 2162 5532636
SGTC_621 3584-0052 32.1 µM 0.0935885221309598 0.466443090367525 no 1552 0.462718013803075 2239 2273927
SGTC_3117 9124945 49.47 µM 0.092680172029838 0.46678085445241 no 1553 0.463078824814654 2077 17592065
SGTC_1752 st044819 83.042 µM 0.0924748088612664 0.466857220737227 no 1554 0.463160402530535 2164 441209 YML126C ERG13
SGTC_2335 9018011 154.17 µM 0.0918996241896077 0.467071115217719 no 1555 0.463388895026418 2202 6458208
SGTC_926 2268-1401 59.4 µM 0.0918681003507372 0.467082838293617 no 1556 0.463401418242319 2259 2931578
SGTC_1880 MG-132 525 µM 0.0914559956073796 0.467236094306758 no 1557 0.463565135031985 2244 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_596 1155-0152 116 µM 0.0913384645974125 0.467279803343217 no 1558 0.463611827690766 2222 280313
SGTC_3088 9117578 49.47 µM 0.0912120107053219 0.467326831183485 no 1559 0.463662065787299 2228 678341
SGTC_1260 0700-1617 7.75 µM 0.0892263379584145 0.468065356579238 no 1560 0.464451017095123 2165 2853078
SGTC_2460 5552655 174.22 µM 0.0887263063342553 0.468251349288785 no 1561 0.464649712775172 2109 5401989
SGTC_1755 st041960 45.185 µM 0.0876866255172083 0.468638093072479 no 1562 0.465062874982691 2171 2257073
SGTC_1096 rimcazole 32.2 µM 0.0867755587918395 0.468977018920706 no 1563 0.465424957791552 2135 18528119 A dopamine reuptake inhibitor.
SGTC_158 k038-0087 26.446 µM 0.0852451127861804 0.469546410478952 no 1564 0.46603326313156 2146 X158
SGTC_2379 9035213 200 µM 0.0851007503893048 0.469600122715314 no 1565 0.466090646874255 2275 646551
SGTC_1546 5-methoxyflavanone 78.7 µM 0.0843922667805913 0.46986373287238 no 1566 0.466372277784383 2269 147795
SGTC_1327 1436-0082 2.18 µM 0.0840809768100848 0.469979560763194 no 1567 0.466496024692644 2112 15992205
SGTC_212 3807-4682 38.772 µM 0.0837103790388737 0.470117459806154 no 1568 0.46664335241639 2220 3125501 YBL034C STU1
SGTC_2715 st079500 56.4 µM 0.0824280482200173 0.470594641313265 no 1569 0.467153166340699 2229 28246688
SGTC_2755 lomerizine 42.69 µM 0.0822199840327536 0.470672070249512 no 1570 0.467235891143325 2202 3949 A calcium channel blocker.
SGTC_2448 5185112 27.17 µM 0.0820342164196683 0.470741202683186 no 1571 0.467309752186694 2162 5718189
SGTC_2853 9015042 58.44 µM 0.0802365545367461 0.471410238278439 no 1572 0.468024558777137 2244 6457456
SGTC_2717 st081029 62.2815 µM 0.0789988083745997 0.471870937130937 no 1573 0.46851678544101 2263 5292846
SGTC_1314 1222-0010 41.1 µM 0.0781793442754745 0.472175968858339 no 1574 0.468842696300388 2183 3526027
SGTC_105 0111-0055 734.78 µM 0.0779312983893601 0.472268302993095 no 1575 0.468941351299001 2198 5179370
SGTC_1435 4092-0789 56.7 µM 0.0778354331349519 0.472303988867875 no 1576 0.468979480185194 2281 2248285
SGTC_2851 9015922 71.43 µM 0.0776134532759878 0.472386621801649 no 1577 0.469067770248911 2241 2996893
SGTC_1234 0326-0494 15.5 µM 0.0774048082453463 0.472464291873256 no 1578 0.469150757917235 2236 1547813
SGTC_2603 homopterocarpin 100 µM 0.0769413029577498 0.472636839810761 no 1579 0.46933511995308 2198 101795 A weak amylase inhibitor.
SGTC_3000 9075062 71.4286 µM 0.0761490934715466 0.472931765497394 no 1580 0.469650241275979 2173 17057871
SGTC_1363 1636-0063 10.4 µM 0.0759237860112725 0.47301564622759 no 1581 0.469739866487064 2258 6072185
SGTC_2096 5468907 200 µM 0.0755525907108271 0.473153842807454 no 1582 0.469887527864925 2253 759785
SGTC_3213 9129884 49.47 µM 0.0748540469808944 0.473413920458893 no 1583 0.470165419562084 2185 17190742
SGTC_2347 9049783 174.81 µM 0.0733730859589567 0.473965340414318 no 1584 0.470754617073386 2224 6467988 YPL169C MEX67
SGTC_756 0508-1999 28.3 µM 0.0728436844820549 0.474162469535513 no 1585 0.470965254040519 2139 6753853
SGTC_1640 st009078 66.4 µM 0.0699763801177731 0.475230254111988 no 1586 0.472106229738909 2280 690618
SGTC_2824 7998404 51.95 µM 0.0696880455895291 0.475337639906731 no 1587 0.472220978443146 2239 837851
SGTC_2783 7738165 71.43 µM 0.0691066846241665 0.475554164365757 no 1588 0.472452350095539 2194 17201110
SGTC_3192 9110362 49.47 µM 0.0684078109740912 0.475814465280509 no 1589 0.47273050206992 2275 16649480
SGTC_1162 k048-0130 20.1 µM 0.0657618054713977 0.476800083154274 no 1590 0.473783732599804 2197 6797406
SGTC_1567 st069303 68.4 µM 0.064120666156515 0.477411467361071 no 1591 0.474437073246105 2203 5581319
SGTC_1512 0259-0544 12.2 µM 0.0639458451214473 0.477476597726859 no 1592 0.474506673911704 2189 18476
SGTC_1539 benzyladenosine 56 µM 0.0636903774609393 0.477571774438427 no 1593 0.474608383432658 2288 92208 A nucleotide analog.
SGTC_914 3820-6779 408 µM 0.0632629619092687 0.477731014698777 no 1594 0.474778554386794 2290 2893481
SGTC_2466 5983409 37.09 µM 0.0629509886533964 0.477847247396277 no 1595 0.474902766125972 2181 2879657
SGTC_2876 9059903 25.97 µM 0.0606827779376228 0.478692376670191 no 1596 0.475805923808073 2292 6916095
SGTC_1627 st003713 25.6 µM 0.0593868271941171 0.479175287721927 no 1597 0.476322002458898 2239 16195070 YER133W GLC7
SGTC_2697 mebhydrolin 72.4 µM 0.0583075667945786 0.479577476656944 no 1598 0.47675182017055 2279 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1378 2093-0007 380 nM 0.0578622704013844 0.479743423491693 no 1599 0.476929168301474 2242 3618014
SGTC_2583 asiatic acid 100 µM 0.0578017855175855 0.479765964424116 no 1600 0.476953257960785 2266 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2904 7225135 42.03 µM 0.0576857523178529 0.479809206756775 no 1601 0.476999471400077 2301 4446116
SGTC_763 3453-1109 128 µM 0.0569530307092168 0.48008227710226 no 1602 0.477291305217166 2304 1560353
SGTC_957 1187-1561 14.1 µM 0.0562226353803538 0.480354489794277 no 1603 0.477582224627144 2304 1538454
SGTC_1713 st033146 12.748 µM 0.0558516350979884 0.480492762247808 no 1604 0.477730000123345 2303 674619
SGTC_2817 7995342 71.43 µM 0.0552929225975312 0.480700999796751 no 1605 0.477952550245676 2269 18879975
SGTC_1047 2043-3044 82 µM 0.0547031000305499 0.480920838081559 no 1606 0.47818749979784 2283 669592
SGTC_249 wiskostatin 11.211 µM 0.0543004536416899 0.481070915519288 no 1607 0.478347894067261 2298 2775510 A n-wasp and actin depolymerizer.
SGTC_2698 st077697 67.5 µM 0.0533849976690306 0.481412141212816 no 1608 0.478712579146425 2245 3154499
SGTC_2271 7849410 118.62 µM 0.0530727964776018 0.481528513745887 no 1609 0.478836953081013 2334 972430
SGTC_2471 5466956 24.79 µM 0.0530648468681516 0.481531476971662 no 1610 0.478840120053622 2237 724419
SGTC_3166 9102297 49.47 µM 0.0512877575463753 0.482193914300226 no 1611 0.47954811166458 2253 25237072
SGTC_3175 9106517 49.47 µM 0.050930803961374 0.482326980217515 no 1612 0.479690329671676 2264 41468073
SGTC_598 3937-0236 20.2 µM 0.050567843631306 0.482462287360695 no 1613 0.479834943546625 2288 1379313
SGTC_577 r071-0003 38.6 µM 0.0501953865672795 0.482601136869269 no 1614 0.479983343953767 2315 4568517 YMR134W ERG29
SGTC_1659 st012954 42.1 µM 0.049801522238306 0.482747969158781 no 1615 0.480140276809741 2291 24207262
SGTC_843 0310-0051 143 µM 0.049763216556642 0.482762249609758 no 1616 0.480155539641195 2233 2065037
SGTC_729 4092-0585 94.1 µM 0.0493044283601546 0.482933288674935 no 1617 0.480338345245425 2304 2169061
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0486998959330101 0.483158666877904 no 1618 0.480579229406186 2328 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2157 5649910 96.377 µM 0.0481909656204087 0.48334840744133 no 1619 0.480782025107114 2300 2858091
SGTC_1618 st003135 44.5 µM 0.047352228018546 0.483661115721318 no 1620 0.481116251398042 2314 1270615
SGTC_652 0437-0092 114 µM 0.0457704071755867 0.484250896464014 no 1621 0.481746622867292 2311 3091274
SGTC_2419 paclitaxel 166.5 µM 0.0454245153421882 0.484379866616742 no 1622 0.481884470367551 2247 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_904 1141-0088 396 µM 0.0449086178053389 0.484572228582282 no 1623 0.482090073880575 2223 1378119
SGTC_1612 st002233 45.4 µM 0.0443164418662742 0.484793036788331 no 1624 0.482326082917984 2320 1035021
SGTC_1002 4049-0206 172 µM 0.0435956593790575 0.48506180557758 no 1625 0.482613355861832 2308 4662749
SGTC_2866 9034245 58.44 µM 0.0433445561195338 0.48515543975104 no 1626 0.482713436964713 2333 6462273
SGTC_1137 ixabepilone 100 µM 0.0427915678021046 0.48536164705797 no 1627 0.48293384287665 2337 154225 A novel microtubule stabilizer.
SGTC_1465 k213-0056 144 µM 0.0425392897308733 0.485455721925193 no 1628 0.483034395703647 2227 24048857 YMR208W ERG12
SGTC_2294 7971431 200 µM 0.0416528357098538 0.485786288330084 no 1629 0.483387726477038 2306 5741572
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0413335355344099 0.485905360543832 no 1630 0.48351499920771 2311 364106
SGTC_2038 4100038 30.985 µM 0.0412760976113222 0.485926780210534 no 1631 0.483537894085056 2289 3596803
SGTC_896 0964-0007 44.5 µM 0.0411885446473841 0.485959430412546 no 1632 0.483572792985636 2339 6756758
SGTC_1030 k029-0042 36.7 µM 0.040802914608821 0.486103240466706 no 1633 0.48372650788691 2203 6080581
SGTC_2484 5809818 12.04 µM 0.0402005620826046 0.486327874786093 no 1634 0.48396661475836 2303 2870548
SGTC_1924 st058459 75.1 µM 0.0393261741662516 0.486653966508691 no 1635 0.484315169393319 2341 688683
SGTC_1982 st072467 71.9 µM 0.0391284706800557 0.486727698724754 no 1636 0.484393981012502 2256 3163533
SGTC_2639 lactacystin 53 µM 0.037900784962894 0.487185566103992 no 1637 0.484883393595187 2309 3870 A proteasome inhibitor.
SGTC_1741 st038134 10.228 µM 0.0376093680038636 0.487294253034672 no 1638 0.484999569310353 2309 1272587
SGTC_2480 5767542 37.17 µM 0.0360392371071276 0.487879865422851 no 1639 0.485625536287889 2328 2867358
SGTC_3120 9124077 49.47 µM 0.0360327651176302 0.487882279338475 no 1640 0.48562811656223 2349 18774327 YGL155W CDC43
SGTC_521 r062-0005 13.8 µM 0.0355608562191634 0.488058292598215 no 1641 0.48581626038911 2337 2832033
SGTC_1773 st048542 73.5835 µM 0.0342333489554382 0.488553440530397 no 1642 0.48634553674874 2309 3237138
SGTC_2768 sulfasalazine 50.2 µM 0.0320294385074505 0.489375517334286 no 1643 0.487224287201073 2348 5384001 An antioxidant and salicylic acid derivative.
SGTC_1248 0469-0687 58.6 µM 0.0319991446771579 0.489386817505728 no 1644 0.4872363664991 2309 4017482
SGTC_29 0299-0004 12.984 µM 0.0313820008147482 0.489617025676133 no 1645 0.487482447675244 2344 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2172 5754775 163.918 µM 0.0312404814838112 0.489669815974846 no 1646 0.487538878051025 2324 2263357
SGTC_229 benomyl 22.8748 µM 0.0290498339357505 0.490487005567277 no 1647 0.488412422806233 2297 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2721 ifenprodil 61.44 µM 0.0283059071183996 0.490764526032397 no 1648 0.488709084644923 2337 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1986 st071812 45 µM 0.0261001830101278 0.491587392921697 no 1649 0.48958871554622 2358 11838594
SGTC_1837 st055472 66.5 µM 0.0259311368086865 0.491650458777286 no 1650 0.48965613240502 2322 676091
SGTC_802 4112-3352 742 µM 0.024990646022402 0.492001330269245 no 1651 0.490031212336379 2337 704594
SGTC_115 0527-0192 112.043 µM 0.0248601206699133 0.492050026217775 no 1652 0.490083268245092 2278 4233931
SGTC_1062 mesoridazine 14.2 µM 0.024423623321096 0.492212874000376 no 1653 0.49025735262949 2358 4078 A neuroleptic.
SGTC_3093 9117344 49.47 µM 0.0243647538798546 0.492234837024004 no 1654 0.490280831151825 2333 24824913
SGTC_2274 7947094 46.08 µM 0.0234226383548183 0.49258632484159 no 1655 0.490656573581269 2366 2971028
SGTC_422 cantharidin 155 µM 0.0226835661633122 0.492862064571498 no 1656 0.490951342382835 2371 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2947 9072639 7.68 µM 0.0226380712154025 0.492879038350447 no 1657 0.490969487581606 2362 16488146
SGTC_2747 doxorubicin 7.63 µM 0.0223142287619248 0.492999861592108 no 1658 0.491098649398992 2369 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1106 tegaserod maleate 11.7 µM 0.0173859572921957 0.494838636262812 no 1659 0.493064355960584 2298 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_88 0180-0332 8.668 µM 0.0172352104086679 0.494894882971676 no 1660 0.493124486256118 2381 3101745
SGTC_3086 9117350 49.47 µM 0.017041779173558 0.494967056223286 no 1661 0.493201642821679 2383 2679265
SGTC_2912 7964298 10.93 µM 0.0165729969095565 0.495141969398844 no 1662 0.49338863347218 2365 2975850
SGTC_17 0960-0276 49.807 µM 0.0153509111200422 0.495597961319655 no 1663 0.493876113028618 2376 6821114
SGTC_666 0272-0154 136 µM 0.0152087513070917 0.495651005219707 no 1664 0.493932819968367 2367 6870312
SGTC_1745 st081495 74 µM 0.0128649090341016 0.496525570325402 no 1665 0.494867785421788 2377 13842402 YBL026W LSM2
SGTC_3328 9140624 29.0385 µM 0.0111542771017587 0.497163874481128 no 1666 0.495550179529871 2383 4904392
SGTC_329 k048-0121 21.3 µM 0.00969214508975694 0.4977094593461 no 1667 0.496133454071729 2364 6832902
SGTC_328 k915-0120 63.5 µM 0.00915850703172481 0.497908583969847 no 1668 0.496346335396929 2383 6624543
SGTC_248 streptozotocin 5.23457 mM 0.00889873816309316 0.49800551573794 no 1669 0.496449963957686 2386 5300 DNA alkylating agent.
SGTC_1426 4048-4480 71.7 µM 0.00821487392357909 0.498260697633316 no 1670 0.49672277632387 2395 14224343
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0070960569257459 0.498678182336192 no 1671 0.497169106626017 2383 5377381
SGTC_401 neomycin 50 µM 0.0067040494170061 0.498824459652296 no 1672 0.497325491271648 2361 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_15 0266-0086 27.098 µM 0.0063973030371728 0.49893892195152 no 1673 0.497447862745853 2395 1712902 YIL048W NEO1
SGTC_2977 9011197 71.43 µM 0.00488828807147081 0.499502011425533 no 1674 0.498049862976049 2392 2704722
SGTC_971 1315-0384 26.7 µM 0.00461767115298564 0.49960299236279 no 1675 0.498157822286844 2393 6769120
SGTC_2237 6667747 47.222 µM 0.00444492869049949 0.499667451375823 no 1676 0.498226735851171 2372 729940 YDL015C TSC13
SGTC_2009 4012297 12.05 µM 0.00419606640144998 0.499760314588862 no 1677 0.498326016613388 2392 45595307
SGTC_113 0099-0221 2.5 µM 0.00383430751563224 0.499895305302148 no 1678 0.498470336364118 2396 89219
SGTC_1611 st001856 99.4 µM 0.00327316915210637 0.499895305302148 no 1679 0.49869419676597 2398 647478
SGTC_424 splitomicin 100 mM 0.0026394792410698 0.499658843254594 no 1680 0.498947001355176 2389 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2329 6138490 200 µM 0.00120796565163939 0.499124673043491 no 1681 0.499518091545487 2397 720019
SGTC_1935 st074532 41.6 µM 0.0011646918610377 0.499108525420478 no 1682 0.499535355278042 2402 2829742
SGTC_68 0986-0284 82.829 µM 0.00106028844988068 0.499069567274247 no 1683 0.499577006187177 2399 423278 YIL048W NEO1
SGTC_3334 9142812 21.919 µM 0.000541549180954152 0.498875999788529 no 1684 0.499783953145361 2398 45283678
SGTC_1699 st031318 29.054 µM 0.000484008749723962 0.498854528600127 no 1685 0.49980690845319 2404 5340658
SGTC_2523 spermine 47.74 µM 0.000439871025754632 0.498838058628709 no 1686 0.499824516855562 2404 1103 A DNA binding polyamine.
SGTC_708 3448-5400 146 µM 0 0.498673921070362 no 1687 0.5 2405 3462195
SGTC_2165 5727197 32.143 µM -0.000202350972672216 0.498598414023481 no 1688 0.499919273642072 2406 1361712
SGTC_2980 9014342 25.29 µM -0.000404378478259507 0.49852302772808 no 1689 0.499838676332135 2410 2996599
SGTC_3022 9087993 49.47 µM -0.00099713214328101 0.498301842799594 no 1690 0.499602201894818 2407 17173644
SGTC_3036 9090181 49.47 µM -0.00244528676445587 0.497761468927114 no 1691 0.499024472694135 2407 25236586
SGTC_2746 daunorubicin 9.88 µM -0.00305555921449736 0.49753374905256 no 1692 0.498781010135905 2412 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_182 3448-4371 550.524 µM -0.00471618130472444 0.496914101156412 no 1693 0.49811852285026 2406 3491403
SGTC_1237 0330-0133 46.1 µM -0.00483353078167592 0.496870313398604 no 1694 0.498071707716026 2414 X1237 YHR072W ERG7
SGTC_2858 9025781 8.96 µM -0.00531948125433071 0.496688986354238 no 1695 0.497877844026248 2420 4894980 YPL153C RAD53
SGTC_3346 9158254 43.5805 µM -0.00579017910480783 0.496513351308949 no 1696 0.497690065651213 2419 17639500
SGTC_2034 5197015 53.07 µM -0.0075430967722396 0.495859278112304 no 1697 0.49699076830912 2436 780676
SGTC_496 calpeptin 138 µM -0.00811627927485696 0.49564540655657 no 1698 0.496762108586557 2443 73364 A calpain inhibitor.
SGTC_2722 naftopidil 47.16 µM -0.00904558437770616 0.495298657681229 no 1699 0.496391383151928 2419 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3018 9082602 49.47 µM -0.00910761029666492 0.49527551425636 no 1700 0.496366639409652 2403 17332089
SGTC_2827 7993847 71.43 µM -0.0092787927194648 0.495211641886946 no 1701 0.496298350389401 2433 2985692
SGTC_1485 3909-9022 254 µM -0.00969146113369921 0.49505766566649 no 1702 0.496133726917904 2421 714516
SGTC_2860 9025725 38.96 µM -0.0100698378133166 0.494916485139391 no 1703 0.495982783831645 2433 40546248
SGTC_2223 6903751 107.57 µM -0.010991259920486 0.494572685310489 no 1704 0.495615209989149 2433 5598863
SGTC_175 3793-3120 23.7 µM -0.0116950885743011 0.494310076372476 no 1705 0.495334441050293 2433 5322297
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0129485636865379 0.493842392346074 no 1706 0.494834414823605 2418 279621
SGTC_1129 3453-1384 223 µM -0.0132579751494613 0.493726949130712 no 1707 0.494710988105868 2477 1084452
SGTC_533 1222-0222 6.71 µM -0.0134646519944469 0.493649837090552 no 1708 0.494628543333713 2502 3982874
SGTC_853 0419-0306 21 µM -0.0135679076125203 0.493611312053874 no 1709 0.494587354064594 2434 762713
SGTC_675 1309-0189 238 µM -0.0140091278909074 0.493446691881608 no 1710 0.494411349374087 2440 4246530
SGTC_530 4358-1714 28 µM -0.0170067941950221 0.492328287543532 no 1711 0.493215597786391 2494 1564641
SGTC_2438 5259590 200 µM -0.0171933114047131 0.492258701427685 no 1712 0.493141199063858 2455 1201127
SGTC_368 fentichlor 4.58 µM -0.0184041168798332 0.491806978157014 no 1713 0.492658234102303 2457 7329 A pesticide.
SGTC_1259 0671-0132 43 µM -0.0189534077350176 0.491602053985445 no 1714 0.492439136983092 2451 X1259
SGTC_1908 st060353 56.5 µM -0.0190310145265581 0.491573101364367 no 1715 0.492408181936017 2444 4227716
SGTC_2427 5545055 42.75 µM -0.0195953102600658 0.491362581951429 no 1716 0.49218310249329 2444 5372858
SGTC_932 2857-0803 154 µM -0.0200541483813856 0.491191406932822 no 1717 0.492000088536037 2559 674898
SGTC_167 3672-0051 66.205 µM -0.0201615051867952 0.491151356432675 no 1718 0.491957268024861 2442 3237971
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0213914845590531 0.490692507134434 no 1719 0.491466683175191 2455 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3123 9126162 49.47 µM -0.0225668964514804 0.490254025979168 no 1720 0.49099787495214 2450 25239884
SGTC_1337 1486-1011 40.3 µM -0.0237992728887024 0.489794307160549 no 1721 0.490506360018487 2455 X1337
SGTC_1361 1608-0041 5.61 µM -0.0238859222254272 0.489761984479262 no 1722 0.490471801758563 2450 X1361
SGTC_2806 7952793 58.44 µM -0.0243236338277406 0.489598706562491 no 1723 0.490297230818917 2478 2972490
SGTC_408 cantharidin 100 µM -0.0245412018748217 0.489517548617 no 1724 0.490210459628837 2484 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3005 9076496 71.4286 µM -0.0245873061896788 0.48950035069009 no 1725 0.490192072216676 2459 21368410
SGTC_6 0844-0013 19.835 µM -0.0262624677243184 0.48887549196444 no 1726 0.4895239954977 2453 1584900
SGTC_1763 st044482 94.5 µM -0.0277532045711417 0.488319449145003 no 1727 0.488929494456551 2501 88505
SGTC_832 4083-0019 164 µM -0.0279108237206978 0.48826065872459 no 1728 0.488866637863392 2510 1990758
SGTC_1910 st062352 60.4 µM -0.0284269127886932 0.488068164278651 no 1729 0.488660829785024 2455 2245730
SGTC_1247 0448-0043 5.84 µM -0.0294164204418209 0.487699098728574 no 1730 0.488266238426513 2493 3089013 YGL099W LSG1
SGTC_2805 7950783 58.44 µM -0.0304335997710723 0.487319723208004 no 1731 0.487860624258476 2482 1178958 YDL195W SEC31
SGTC_1411 3909-8223 150 µM -0.0318726933799753 0.486783006769041 no 1732 0.487286787549078 2471 X1411
SGTC_2900 5328528 85.29 µM -0.0320828396162315 0.486704633764281 no 1733 0.487202994184084 2454 795359
SGTC_1292 0kpi-0043 232 µM -0.0324518060722401 0.486567030784151 no 1734 0.487055874474564 2474 3333905
SGTC_563 tetrahydrosecaminediol 614 µM -0.0334854026823418 0.486181568067118 no 1735 0.486643753138412 2490 334274 A psychoactive constituent of the cannabis plant.
SGTC_3100 9120536 49.47 µM -0.033933937931739 0.48601429827904 no 1736 0.48646491510412 2455 16421196
SGTC_1020 4335-0961 93.3 µM -0.033965255411235 0.486002619314906 no 1737 0.48645242843542 2457 669075
SGTC_2024 5144227 134 µM -0.0346014116977852 0.485765385516198 no 1738 0.486198787901668 2484 3475211
SGTC_698 k064-0052 127 µM -0.0352786818856344 0.485512825163712 no 1739 0.485928761069259 2454 5088751
SGTC_1736 st036774 51 µM -0.0353773285540812 0.485476039385962 no 1740 0.485889431293187 2458 1272247
SGTC_1526 st051518 75 µM -0.0354145386089747 0.485462163624462 no 1741 0.485874595925355 2528 673993
SGTC_511 blebbistatin 171 µM -0.036220212111376 0.485161729461746 no 1742 0.485553384814183 2533 3476986 A myosin inhibitor.
SGTC_2051 5263410 176 µM -0.0373767571634165 0.484730470712236 no 1743 0.485092302407531 2462 227584
SGTC_509 pifithrin 175 µM -0.0420155183297125 0.483000929018353 no 1744 0.48324316360139 2480 4817 A p53 inhibitor.
SGTC_2739 tacrine 100.86 µM -0.0421399224994736 0.482954549729411 no 1745 0.483193577434693 2527 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_979 1426-2828 121 µM -0.0445203575662478 0.482067141633589 no 1746 0.482244812536323 2552 747872
SGTC_392 N-ethylmaleimide 8.33 µM -0.0473808970131249 0.481000872191667 no 1747 0.481104826947058 2508 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_759 3486-0358 89.3 µM -0.047871326585342 0.480818077428876 no 1748 0.480909395626038 2490 875103
SGTC_124 0136-0217 7.121 µM -0.0496407059983662 0.480158621452384 no 1749 0.480204353952777 2513 3976905
SGTC_2033 5192550 145 µM -0.0498892939566324 0.480065975867573 no 1750 0.480105304432853 2509 182073
SGTC_649 1123-0311 367 µM -0.0499464242090204 0.480044684297795 no 1751 0.480082541138068 2528 693629 YIL048W NEO1
SGTC_2563 tomatine 8.54 µM -0.0512803177044269 0.479547578940372 no 1752 0.479551075831571 2468 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0517543263628863 0.479370936592479 no 1753 0.479362224513509 2497 442882
SGTC_2213 7173844 200 µM -0.053174349496876 0.478841780307301 no 1754 0.478796496414897 2491 892728
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0535997509385716 0.478683266271072 no 1755 0.478627027475352 2523 1273210
SGTC_727 3032-0951 202 µM -0.0536626803271937 0.478659817667277 no 1756 0.478601958360731 2541 3652836
SGTC_811 0416-0114 265 µM -0.0543532278469865 0.478402512311724 no 1757 0.478326871251786 2565 6612453
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0544362957736883 0.478371560922542 no 1758 0.478293780933571 2674 5282309
SGTC_605 1315-0399 119 µM -0.0545640828062216 0.478323947298698 no 1759 0.478242876938926 2566 24020461
SGTC_2333 9017922 200 µM -0.0551752858622227 0.478096216490884 no 1760 0.477999408980087 2555 3163164
SGTC_2288 7946289 167.31 µM -0.0555989204174792 0.477938376839268 no 1761 0.477830662279185 2522 1246052
SGTC_606 k015-0008 38.6 µM -0.0558215413419382 0.477855433128006 no 1762 0.477741987094399 2533 1970475
SGTC_1321 1326-2144 215 µM -0.0561238289372158 0.477742808885252 no 1763 0.477621580553389 2565 3513030
SGTC_847 0342-0274 5.54 µM -0.0568325125490879 0.477478779380983 no 1764 0.47733930725767 2511 18097
SGTC_1305 1181-0477 144 µM -0.0585382457034333 0.476843326562035 no 1765 0.476659949522779 2557 6252086
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0586215802411681 0.476812282658161 no 1766 0.476626760846384 2484 2333 A French combination drug.
SGTC_3217 9129673 49.47 µM -0.0587453763668755 0.476766166204217 no 1767 0.476577458303681 2572 17248312
SGTC_710 3448-4187 58 µM -0.0590491468946856 0.476653007120388 no 1768 0.476456481406753 2528 3946412
SGTC_2973 9094665 17.96 µM -0.0593190663912426 0.476552459633479 no 1769 0.476348987535089 2598 25237061 YIL048W NEO1
SGTC_1516 st013856 110 µM -0.0595238829885911 0.476476164569172 no 1770 0.476267421662954 2650 5281404 A mutagen and neurotoxin.
SGTC_491 tetrandrine 80.3 µM -0.0607517858489112 0.476018783646733 no 1771 0.47577844433405 2552 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_444 curcumin 90.4 µM -0.0625142120699457 0.475362353757398 no 1772 0.475076672240685 2571 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3139 9095020 49.47 µM -0.0632682634869029 0.475081521534533 no 1773 0.474776443591821 2502 25236292
SGTC_209 4077-0173 175.592 µM -0.0635817249680029 0.474964782355065 no 1774 0.474651641828752 2592 15993494
SGTC_501 nsc-95397 161 µM -0.0646275394453806 0.47457531621611 no 1775 0.474235278617006 2602 262093
SGTC_972 1319-0219 195 µM -0.0657711980425474 0.474149440299878 no 1776 0.473779993600821 2571 23903702
SGTC_2995 9067767 71.4286 µM -0.0662904088558608 0.473956106148738 no 1777 0.473573309526965 2581 11673567
SGTC_2652 actinonin 100 µM -0.067223195807935 0.473608787577836 no 1778 0.473202009652548 2516 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2656 pseudo-anisatin 100 µM -0.0677794494905649 0.473401678823873 no 1779 0.472980601532925 2524 6708809 A neurotoxin.
SGTC_2056 5235370 200 µM -0.0677904534172209 0.473397581827534 no 1780 0.472976221675183 2573 5511916
SGTC_2219 9098279 200 µM -0.0686748811331727 0.473068299785201 no 1781 0.47262420646933 2534 902349
SGTC_48 0382-0018 55 µM -0.0690218224876313 0.472939134764567 no 1782 0.472486124543786 2533 762596
SGTC_3015 9080845 49.47 µM -0.0699865817162151 0.472579973366909 no 1783 0.472102169843626 2602 5296973
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.0706098686417312 0.472347947408154 no 1784 0.471854127989684 2506 6708630 An antioxidant.
SGTC_622 1348-1566 26.3 µM -0.0711549867159282 0.472145028421674 no 1785 0.471637202980004 2597 7340407
SGTC_961 1252-1571 372 µM -0.0712736346268226 0.472100862957892 no 1786 0.471589989185676 2561 6813498
SGTC_431 k089-0097 107 µM -0.0715844160559939 0.471985179396732 no 1787 0.471466321220375 2520 5499420
SGTC_2582 agaric acid 100 µM -0.0723537095144163 0.471698832038801 no 1788 0.471160211323862 2528 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3312 9133330 71.43 µM -0.0730059352935551 0.471456071209617 no 1789 0.470900697217767 2676 17617324
SGTC_953 1188-0045 9.7 µM -0.0758587378070549 0.470394373468868 no 1790 0.469765742342806 2621 6144426
SGTC_1409 3909-8004 61.9 µM -0.0763244838008912 0.470221061423404 no 1791 0.469580473699248 2571 2119279
SGTC_2636 apigenin dimethyl ether 100 µM -0.0763349485050953 0.470217167392766 no 1792 0.469576311030293 2631 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3343 9148379 18.9835 µM -0.0800441911558717 0.468837099895675 no 1793 0.468101054621522 2600 1955036
SGTC_888 0916-0002 6.97 µM -0.0801810690843054 0.468786179907735 no 1794 0.468046623180626 2723 2802138 YIL048W NEO1
SGTC_2444 5485484 36.41 µM -0.0816123927744773 0.468253743612601 no 1795 0.467477473081456 2625 6790631
SGTC_333 3486-0131 40.1 µM -0.0823104088591815 0.467994110027419 no 1796 0.46719993871808 2682 6744690
SGTC_1088 bifonazole 369 nM -0.0828703720724898 0.46778583632977 no 1797 0.466977306323031 2523 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2595 hexamethylquercetagetin 100 µM -0.0829657988927388 0.467750343989065 no 1798 0.466939367177768 2623 386331
SGTC_2248 tofa 1.1 µM -0.0830947013169952 0.467702401388658 no 1799 0.466888119506828 2555 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3239 9133757 49.47 µM -0.083680205533812 0.467484641067768 no 1800 0.466655347816345 2547 17036923
SGTC_2879 9041815 71.43 µM -0.0846067429595368 0.467140063821349 no 1801 0.466287019093222 2556 4942971
SGTC_1778 st046819 58.9 µM -0.0852231797005756 0.466910825967944 no 1802 0.466041981440515 2561 671715
SGTC_1760 st045453 10.4495 µM -0.0860787917006667 0.466592662849329 no 1803 0.465701891404861 2557 3323419 YIL048W NEO1
SGTC_2684 capsaicin 100 µM -0.0894508023927847 0.465338975482388 no 1804 0.464361825389608 2656 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1311 1190-0148 100 µM -0.0897080537986197 0.465243345372878 no 1805 0.464259607872163 2646 1961333
SGTC_2457 5731572 11.68 µM -0.0905050953680488 0.464947067544215 no 1806 0.463942922527303 2596 2865357
SGTC_1356 1502-0781 85.8 µM -0.0911694187169065 0.464700138829181 no 1807 0.463678987029434 2550 567702
SGTC_549 1661-1316 519 µM -0.0925013700853184 0.464205094100801 no 1808 0.46314985135949 2604 2857282
SGTC_3033 9090887 49.47 µM -0.0930610448712344 0.46399709694956 no 1809 0.462927532389321 2574 19325384
SGTC_439 amiodarone 34.4 µM -0.095180428497702 0.463209540336689 no 1810 0.462085757599522 2654 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1004 4084-0029 199 µM -0.095464621201285 0.463103946073214 no 1811 0.461972895037474 2632 716894 YLR208W SEC13
SGTC_544 k015-0020 52.4 µM -0.0974061355710968 0.462382629502305 no 1812 0.461201936210034 2618 3008304
SGTC_1354 1498-1681 81 µM -0.0974237799415736 0.462376074782534 no 1813 0.461194930444841 2647 5754243
SGTC_1401 3807-4679 7.6 µM -0.0983686194102708 0.462025090662337 no 1814 0.460819795942088 2573 3291456
SGTC_841 0251-0215 91.2 µM -0.0988113436211384 0.461860639900321 no 1815 0.460644030833417 2647 3888614
SGTC_758 0868-0029 16 µM -0.100825386003077 0.461112602689808 no 1816 0.45984453720466 2645 762687
SGTC_1043 0916-0009 19.3 µM -0.101363585460964 0.460912732750591 no 1817 0.459630921070573 2568 3101130
SGTC_2954 9074818 52.69 µM -0.103210966713348 0.460226750293072 no 1818 0.458897768109204 2669 16648742
SGTC_2733 amorolfine 100 µM -0.103790001631842 0.460011763286994 no 1819 0.458668000578458 2620 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2041 5107442 45.335 µM -0.105304570741672 0.459449481865978 no 1820 0.45806706810799 2631 793005
SGTC_1563 conessine 56.1 µM -0.105641549990016 0.459324389835391 no 1821 0.457933378530085 2666 441082 An anti-amoebic, histamine inhibitor.
SGTC_3278 9139605 49.47 µM -0.106085328726578 0.459159658290008 no 1822 0.45775732571743 2802 7958859
SGTC_2284 7945075 39.21 µM -0.106826145015508 0.45888468145428 no 1823 0.457463452716726 2686 1245402
SGTC_927 2425-1185 123 µM -0.107669254944002 0.458571759116658 no 1824 0.457129029350456 2576 730375
SGTC_2249 haloperidol 116.36 µM -0.108463402802801 0.458277032647345 no 1825 0.456814054769823 2590 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1149 3909-7961 23.3 µM -0.10869228124537 0.458192094863091 no 1826 0.456723282128346 2626 735261
SGTC_1197 1601-0112 267 µM -0.109242182393314 0.457988031969092 no 1827 0.456505201890932 2584 7350313
SGTC_3354 9151612 71.43 µM -0.11037634731354 0.457567189581336 no 1828 0.456055455304656 2684 27261949
SGTC_1534 6-azauridine 81.6 µM -0.111695197625891 0.457077877825495 no 1829 0.455532543621262 2573 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2586 curcumin 80 µM -0.112325120176509 0.456844190737847 no 1830 0.4552828124089 2696 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1382 3002-2117 298 µM -0.112555009322716 0.456758910751729 no 1831 0.455191677830254 2641 1497314
SGTC_1034 k072-0165 12.7 µM -0.112757947362884 0.456683630238895 no 1832 0.455111229394009 2631 5835461
SGTC_2955 9076254 12.21 µM -0.113613872762452 0.456366139120819 no 1833 0.454771944844681 2621 16459619
SGTC_2094 5332512 191.667 µM -0.113773311156277 0.456307001204278 no 1834 0.454708747900316 2708 755774
SGTC_2285 7945142 200 µM -0.114309631602244 0.456108079606731 no 1835 0.454496173816835 2698 2970608
SGTC_1939 st074455 53.6 µM -0.114560016381773 0.456015215495055 no 1836 0.454396936645762 2763 1644229
SGTC_3075 9116269 49.47 µM -0.115024084117454 0.455843105807077 no 1837 0.454213016187115 2740 17015205 YNL244C SUI1
SGTC_395 anisomycin 6.25 µM -0.115127766353306 0.455804654109388 no 1838 0.454171925930447 2655 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2124 5246320 200 µM -0.115507499717025 0.455663829351384 no 1839 0.454021438176067 2700 579342
SGTC_94 0334-0113 514.748 µM -0.115671965527248 0.455602838656095 no 1840 0.453956262672866 2615 6795178
SGTC_674 0498-0004 451 µM -0.116030906387181 0.455469732239246 no 1841 0.453814023732339 2633 4231473
SGTC_2107 5363541 170.161 µM -0.116730658145149 0.455210256942533 no 1842 0.453536747331928 2614 244052
SGTC_1954 st077032 68.9 µM -0.118408979380267 0.454587995889782 no 1843 0.452871805658353 2700 698907
SGTC_968 1309-0633 340 µM -0.118582155780665 0.454523794635278 no 1844 0.452803201606611 2626 3761976
SGTC_276 colchicine 750 µM -0.11999461126765 0.454000203047407 no 1845 0.452243708350357 2734 2833 A microtubule depolymerizer.
SGTC_964 1287-0107 19.4 µM -0.120374461830491 0.453859407567202 no 1846 0.452093260394044 2727 51516812 YPR165W RHO1
SGTC_1290 0986-0249 10.2 µM -0.120501172996079 0.453812442071898 no 1847 0.452043075250286 2655 53329
SGTC_78 0336-0123 156.75 µM -0.120760968013404 0.453716151065468 no 1848 0.451940183397712 2604 6765896
SGTC_3295 9122362 53.5725 µM -0.121254343608834 0.453533292725286 no 1849 0.451744790816588 2692 4730473
SGTC_567 1080-0542 68.4 µM -0.122287447350921 0.453150428490758 no 1850 0.451335686474134 2620 5950415
SGTC_34 0469-0683 81.75 µM -0.122741468590122 0.452982183735394 no 1851 0.451155912467843 2700 3690923
SGTC_483 fpl-64176 144 µM -0.123323718641213 0.452766434120783 no 1852 0.450925379716673 2630 3423
SGTC_396 dithiazanine 1.25 µM -0.1235239926413 0.452692226890482 no 1853 0.450846088198002 2638 10578 An antihelmenthic.
SGTC_3195 9113082 49.47 µM -0.124254392329042 0.452421606990213 no 1854 0.450556928512454 2598 17018038
SGTC_1315 1237-0019 3.69 µM -0.124651932386172 0.452274323969406 no 1855 0.450399556443566 2691 825140
SGTC_351 caspofungin 25 nM -0.125411828442852 0.451992811419356 no 1856 0.450098762152132 2660 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1947 st076332 61.6 µM -0.125720223562455 0.451878569649344 no 1857 0.449976696398209 2691 24208416
SGTC_587 k089-0003 57 µM -0.125931846590328 0.451800178400639 no 1858 0.449892936706086 2619 9659696
SGTC_270 tamoxifen 5.46 µM -0.126237592654204 0.451686924595325 no 1859 0.449771927371796 2736 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.12717823911874 0.451338517032889 no 1860 0.449399664090387 2635 16623 A steroid.
SGTC_112 phenothiazine 287.218 µM -0.127201268800781 0.451329987500764 no 1861 0.449390550591054 2619 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1008 4106-0037 6 µM -0.127393344595673 0.451258849024146 no 1862 0.449314541783508 2606 2905394
SGTC_3133 9127736 49.47 µM -0.127551732948272 0.451200188431597 no 1863 0.449251865270343 2602 27243420
SGTC_63 0099-0242 26.702 µM -0.129487574622748 0.450483318041051 no 1864 0.448485928096953 2629 3898502 YLR359W ADE13
SGTC_505 gw-5074 63.9 µM -0.130500765167896 0.450108183053534 no 1865 0.448085124401848 2748 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2537 larixol 68.93 µM -0.131320426007362 0.449804735267208 no 1866 0.447760917048178 2610 6708759
SGTC_958 1222-0007 33 µM -0.131634717674901 0.449688388683646 no 1867 0.447636611862203 2774 7312461
SGTC_1678 st019265 80.2 µM -0.131850370403398 0.449608559420979 no 1868 0.447551322239436 2698 5367020
SGTC_2956 9076196 2.52 µM -0.134020945710175 0.448805180668309 no 1869 0.446693005785352 2713 16423868
SGTC_366 0181-0206 4.31 µM -0.13587117841539 0.448120533478931 no 1870 0.445961560219198 2701 274874
SGTC_1697 st025554 27.742 µM -0.136117724952568 0.448029314741557 no 1871 0.445864107728307 2638 1269519
SGTC_2861 9024595 19.48 µM -0.136259470310855 0.447976872204363 no 1872 0.445808081497115 2643 16482810
SGTC_18 0111-0177 500 nM -0.136425100286461 0.447915594057667 no 1873 0.445742616009707 2652 721752
SGTC_1833 st055984 71 µM -0.136956170465044 0.447719122333808 no 1874 0.445532719737686 2687 676288
SGTC_2863 9028737 58.44 µM -0.138042212898578 0.447317376194988 no 1875 0.445103527906601 2770 6460917
SGTC_2627 acetyl isogambogic acid 100 µM -0.140349141400075 0.44646418273185 no 1876 0.444192069649912 2749 6857789 A caspase activator and apoptosis inducer.
SGTC_2199 6590217 200 µM -0.140724067218505 0.446325543628175 no 1877 0.444043965701501 2692 703109
SGTC_3156 9099931 49.47 µM -0.141117232326752 0.446180167094694 no 1878 0.443888665225976 2667 18111053
SGTC_2161 5662504 8.5105 µM -0.141713091121199 0.445959856441505 no 1879 0.443653317043485 2683 2859334
SGTC_1801 st050089 28.441 µM -0.142134120139049 0.445804196765876 no 1880 0.443487033892853 2646 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1562 morin hydrate 59.1 µM -0.142289940413281 0.445746590184861 no 1881 0.443425496033179 2830 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_410 α-linolenic acid 100 µM -0.144352636588081 0.444984122110436 no 1882 0.442611007763534 2780 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_61 0978-8327 98.565 µM -0.145366857044997 0.444609293690766 no 1883 0.44221061545998 2652 6150059 YHR072W ERG7
SGTC_2709 st078560 56 µM -0.147633745510031 0.443771692644021 no 1884 0.441315910922485 2748 17250903
SGTC_746 1095-0025 46.6 µM -0.147774148684283 0.443719822773382 no 1885 0.441260505839623 2797 6749286
SGTC_705 1124-0212 310 µM -0.148282510960278 0.443532023941147 no 1886 0.44105990850304 2674 9554485
SGTC_1205 4161-2785 76 µM -0.14886094301685 0.443318355406569 no 1887 0.44083168035766 2821 3498106
SGTC_2968 9090663 33.37 µM -0.149471637752681 0.443092787161729 no 1888 0.440590743865488 2768 25236811
SGTC_1644 st010134 20.9 µM -0.149605629854478 0.44304329785653 no 1889 0.440537883098389 2687 3818134
SGTC_2765 myclobutanil 7.74 µM -0.149813618232656 0.442966480161206 no 1890 0.440455832411978 2757 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_261 5-fluorouridine 15.376 µM -0.149920518327033 0.442926998890607 no 1891 0.440413661693801 2850 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1145 3546-0597 10.2 µM -0.150347153804622 0.442769435821239 no 1892 0.44024536619745 2715 875334
SGTC_3238 9133470 49.47 µM -0.152008443987668 0.442155982170622 no 1893 0.439590137855097 2804 3534688
SGTC_2087 5276107 200 µM -0.153350412552696 0.441660543498261 no 1894 0.439060973653925 2676 144405
SGTC_2891 9063876 19.48 µM -0.155192530332664 0.440980604514095 no 1895 0.438334768438004 2741 6472478
SGTC_2502 avocadyne acetate 18.59 µM -0.155850437461892 0.440737808289023 no 1896 0.438075456491507 2647 3952079
SGTC_1370 2001-0092 44.6 µM -0.15622844586992 0.440598316885229 no 1897 0.437926477731403 2801 790957
SGTC_3254 9136651 49.47 µM -0.156732277414236 0.44041240610895 no 1898 0.437727923875159 2678 16454030
SGTC_952 1185-0122 232 µM -0.1568625593609 0.440364334998517 no 1899 0.437676583900936 2646 678600
SGTC_2540 epiandrosterone 100 µM -0.157300854710071 0.440202620321103 no 1900 0.437503873341943 2707 441302 A steroid.
SGTC_1438 4092-1045 4 µM -0.161819802177486 0.438535883200253 no 1901 0.43572387934122 2687 1351342
SGTC_2710 st078562 53.7235 µM -0.162387821420718 0.438326455409969 no 1902 0.435500230325725 2666 17250908
SGTC_880 0833-0487 87.2 µM -0.16271703406445 0.438205083133998 no 1903 0.435370617247373 2701 76075
SGTC_2831 7999036 19.48 µM -0.162820724016761 0.438166856505496 no 1904 0.435329795301289 2986 2988270
SGTC_862 0452-0056 10.2 µM -0.165095155937676 0.437328503797071 no 1905 0.434434542848088 2689 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_765 1319-0117 244 µM -0.166185849226367 0.436926575202873 no 1906 0.434005347639011 2707 3487746 YGL099W LSG1
SGTC_1513 0337-0559 19 µM -0.166574581321429 0.436783340246268 no 1907 0.433852397699155 2723 775073
SGTC_1808 st050063 61.5 µM -0.166711900501296 0.43673274463714 no 1908 0.433798370669132 2787 4011993
SGTC_76 0433-0009 400.328 µM -0.167798929574039 0.436332262536272 no 1909 0.433370732317904 2848 2841569
SGTC_108 0509-0257 621.132 µM -0.167829751672227 0.436320908040964 no 1910 0.433358608007677 2804 536624
SGTC_2464 5717415 7.67 µM -0.168767245437906 0.435975571574279 no 1911 0.432989861533231 2706 5285744
SGTC_2682 pyrogallin 40.03 µM -0.168807059023657 0.435960906866708 no 1912 0.432974202857551 2740 822798 An ATP competetive kinase inhibitor.
SGTC_2405 ticlatone 3.52 µM -0.168864176133467 0.435939868832198 no 1913 0.432951738892952 2628 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1782 st039423 80.636 µM -0.169682974370263 0.435638299547916 no 1914 0.43262973218792 2762 2068169
SGTC_2791 5663188 71.43 µM -0.170342382489915 0.43539546198688 no 1915 0.432370440940314 2858 54690634
SGTC_2323 6148992 148.28 µM -0.170649989399319 0.435282189161655 no 1916 0.432249494272334 2763 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_281 1672-3440 14.9 µM -0.170655876122211 0.435280021493139 no 1917 0.432247179758374 2801 6833000
SGTC_1548 st061468 90.8 µM -0.171451228991409 0.434987166541309 no 1918 0.431934488077763 2813 390799
SGTC_908 3448-7491 47.7 µM -0.17194862874845 0.434804038296704 no 1919 0.43173895783402 2729 1203031
SGTC_2708 st078559 56 µM -0.173289958802389 0.434310269075044 no 1920 0.431211758003348 2741 17250902
SGTC_1395 3486-0190 4.35 µM -0.173377212928153 0.434278152705336 no 1921 0.431177467650822 2785 6748079
SGTC_1419 3993-2473 62.6 µM -0.17350725291765 0.434230288583156 no 1922 0.431126363671026 2734 704026
SGTC_3252 9135871 49.47 µM -0.173539506312406 0.434218417150135 no 1923 0.431113688695905 2859 17682838
SGTC_3299 9121982 43.1275 µM -0.174773840642023 0.433764143220533 no 1924 0.430628672040607 2751 17594604 YPL160W CDC60
SGTC_1286 0929-0070 131 µM -0.175014873900598 0.433675445575931 no 1925 0.430533973141724 2835 1420408
SGTC_2279 7948423 32.93 µM -0.175181497339724 0.433614131896113 no 1926 0.430468511248583 2751 1247112
SGTC_657 3534-0529 86.7 µM -0.175280389961071 0.433577742389961 no 1927 0.43042965988584 2870 1049549
SGTC_1124 fisetin 1.16336 µM -0.176026751151058 0.433303122132631 no 1928 0.430136463099946 2791 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2073 5212005 126 µM -0.1761544479191 0.433256139901054 no 1929 0.430086303196558 2690 691789
SGTC_2743 auranofin 4.32 µM -0.17726974290856 0.432845840414944 no 1930 0.429648258020083 2753 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2544 sphondin 68.51 µM -0.177460560387284 0.432775648905348 no 1931 0.429573320880051 2953 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3198 9112019 49.47 µM -0.179426586495647 0.432052577314604 no 1932 0.428801378556368 2722 45595555
SGTC_1147 3809-1045 12.3 µM -0.182138750153216 0.431055462735818 no 1933 0.427736919546968 2731 325925
SGTC_1310 1188-0297 994 nM -0.182203253152762 0.431031753825551 no 1934 0.427711610040952 2782 1588352
SGTC_469 w7 172 µM -0.182245601178365 0.431016188397137 no 1935 0.427694993803204 2734 45115570 A P450 inhibitor.
SGTC_441 propafenone 146 µM -0.182386922476668 0.430964245155914 no 1936 0.427639544016578 2710 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1973 st070275 50.2 µM -0.18274295152681 0.430833390467579 no 1937 0.427499856373005 2684 17118334
SGTC_237 nikkomycin 200 µM -0.183492124296422 0.430558064805398 no 1938 0.427205948884814 2872 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2185 6113692 200 µM -0.184615657697785 0.430145222583344 no 1939 0.426765251992769 2856 874150
SGTC_2670 beta-carotene 100 µM -0.185288908362655 0.42989787325858 no 1940 0.426501218623395 2802 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2350 9023895 38.85 µM -0.185602593027967 0.429782636285649 no 1941 0.426378209979273 2865 2997209
SGTC_1084 voriconazole 435 nM -0.185958897500063 0.429651749516279 no 1942 0.426238497045696 2760 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1705 st027868 56.3335 µM -0.187430506501028 0.429111242953455 no 1943 0.425661552840641 2815 292948
SGTC_2413 inermin 26.06 µM -0.18748351627234 0.429091775493722 no 1944 0.4256407733253 3044 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2258 7960471 200 µM -0.187830205901885 0.428964460459334 no 1945 0.425504878145262 2792 2974708
SGTC_2074 5212007 75.395 µM -0.188901101837016 0.428571241449975 no 1946 0.425085164991558 2756 758611
SGTC_2781 5567276 71.43 µM -0.189176923973228 0.428469974628057 no 1947 0.424977076548034 2898 2853274
SGTC_450 aminopyrene 156 nM -0.19010073798687 0.42813083492483 no 1948 0.424615095898218 2794 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.191808596974443 0.427504005824456 no 1949 0.423946068296033 2783 688788
SGTC_2187 6125751 200 µM -0.192078331008716 0.427405023039289 no 1950 0.423840424107849 2794 874498
SGTC_548 1436-0017 110 µM -0.192581160255444 0.427220514815614 no 1951 0.423643500331089 2850 9677137
SGTC_2545 solidagenone 89.61 µM -0.19262373678792 0.427204892508204 no 1952 0.423626826894398 2693 6708572 An anti ulcer agent
SGTC_1675 st018485 24.5 µM -0.193140554767512 0.427015269234646 no 1953 0.423424446222739 2825 3323024
SGTC_1489 4065-0444 182 µM -0.195373266802062 0.426196269616081 no 1954 0.422550371665525 2776 2877968
SGTC_280 3448-3607 3.04 µM -0.195980649372358 0.425973525485561 no 1955 0.422312655929671 2827 626179
SGTC_1642 st009582 77.7 µM -0.197821634173289 0.425298529567447 no 1956 0.421592309515888 2871 6739311
SGTC_2153 5569715 200 µM -0.198127828933653 0.425186284630414 no 1957 0.421472526029005 2761 2054701
SGTC_232 clozapine 119 µM -0.199807762014123 0.424570562564155 no 1958 0.42081546526545 2743 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1199 1638-0010 4.46 µM -0.200419360753466 0.424346447556509 no 1959 0.420576309483739 2754 3111136
SGTC_1510 1123-0200 71.5 µM -0.201279160062639 0.424031422999388 no 1960 0.420240148479284 2969 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2674 ligustilide 100 µM -0.201956812950976 0.423783169830362 no 1961 0.419975243356424 2857 5319022 A signalling regulator.
SGTC_1624 st003710 6.25 µM -0.202058477540762 0.423745928359809 no 1962 0.419935504201117 2954 24207033
SGTC_2181 6316240 54.2555 µM -0.202225749333263 0.423684655335939 no 1963 0.419870121956136 2839 12779990
SGTC_419 nsc-638432 893 µM -0.203123167792769 0.423355955164997 no 1964 0.419519381948554 2848 368090
SGTC_901 1112-0062 60.1 µM -0.203151033237983 0.423345749656756 no 1965 0.419508492257963 2770 1908457
SGTC_1322 1348-1070 12 µM -0.203471411068097 0.423228417399607 no 1966 0.419383294474496 2757 6758089
SGTC_2524 avocatin b 10.57 µM -0.203677659853231 0.423152886325579 no 1967 0.419302700547092 2871 6710748
SGTC_1434 4073-0095 163 µM -0.20407790607714 0.423006318845979 no 1968 0.419146309700198 2783 24133745
SGTC_2298 7976326 193.81 µM -0.205047737786751 0.422651217217634 no 1969 0.418767413982364 2794 2235818
SGTC_1525 8-methoxypsoralen 92.5 µM -0.205164975135845 0.422608295286656 no 1970 0.418721616566737 3026 4114 Related to psoralen; DNA damaging agent.
SGTC_769 0302-0231 76 µM -0.205717227547035 0.422406121745581 no 1971 0.418505900369954 2849 571869 YER009W NTF2
SGTC_2865 9030313 51.95 µM -0.207405044213262 0.421788357526501 no 1972 0.417846771769087 2750 42562754
SGTC_227 fluconazole 33.516 µM -0.208288904533939 0.421464929105905 no 1973 0.4175016972831 2797 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_669 0108-0021 26.2 µM -0.209065137406658 0.4211809281687 no 1974 0.417198694811637 2757 17201
SGTC_2909 7941780 10.49 µM -0.209414045475911 0.42105328624571 no 1975 0.417062514567303 2826 1243215
SGTC_152 4469-0003 551.229 µM -0.210270667464035 0.420739941274265 no 1976 0.416728213741322 2780 697280
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.210490235621041 0.420659633203268 no 1977 0.416642535903332 2892 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1157 4092-0394 27.6 µM -0.211346600034351 0.420346445533831 no 1978 0.416308411245582 2963 3659885
SGTC_2897 9048598 12.99 µM -0.213498929126022 0.419559523617692 no 1979 0.415468912149102 2800 6467404
SGTC_2423 st077119 87.2 µM -0.215178066138995 0.418945830543705 no 1980 0.414814245537201 2725 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1859 st055998 20 µM -0.215240362018768 0.418923066352584 no 1981 0.41478996198512 2897 676301
SGTC_3285 9112818 20.8695 µM -0.217496572001789 0.418098784523383 no 1982 0.413910689104648 2774 17017947 YPR165W RHO1
SGTC_2934 9036370 36.88 µM -0.217581058640626 0.41806792520963 no 1983 0.413877771971059 2900 6462800
SGTC_2928 9011484 9.79 µM -0.217650074754749 0.418042716983512 no 1984 0.413850882811513 2920 2994751
SGTC_522 1273-0010 11.6 µM -0.217846156221219 0.417971099808431 no 1985 0.413774490308558 3023 5705015
SGTC_3138 9097216 49.47 µM -0.217899086514879 0.417951767911451 no 1986 0.41375386945111 2729 25237486
SGTC_2065 5221596 34.26 µM -0.218603832554348 0.417694390217585 no 1987 0.413479333531381 2921 788581
SGTC_2622 2-methoxyxanthone 59.94 µM -0.218782709461064 0.417629068849324 no 1988 0.41340965822369 2851 71034 A hepatoprotective.
SGTC_1442 4112-3290 3 µM -0.219005311108598 0.41754778347459 no 1989 0.413322955264802 2789 704353
SGTC_2361 9034121 116 µM -0.219752393171516 0.417275004234107 no 1990 0.413031999006714 2826 6496917
SGTC_349 k015-0014 24 µM -0.220161933518961 0.417125487205496 no 1991 0.412872520954307 2773 2196908
SGTC_36 0335-0881 14.2 µM -0.22115379120431 0.416763424565355 no 1992 0.412486343837393 2771 23828853
SGTC_2810 7959871 45.46 µM -0.222433040988219 0.416296558067675 no 1993 0.411988396501101 2909 2974535
SGTC_3121 9125696 49.47 µM -0.222842676619478 0.416147085096491 no 1994 0.411828975945778 2794 1235365
SGTC_69 0096-0274 206.684 µM -0.224513549695483 0.415537521876033 no 1995 0.411178862437387 3096 6741392
SGTC_1107 amlodipine 47 µM -0.228464916183627 0.414096806456309 no 1996 0.409642413869083 2865 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2776 terbinafine 19.92 µM -0.234370300041944 0.411945791897765 no 1997 0.407348756862167 2823 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1777 st045864 34.765 µM -0.23477163129203 0.411799703642995 no 1998 0.407192993672669 2824 4691462
SGTC_3241 9133421 49.47 µM -0.235730149812056 0.411450843612234 no 1999 0.406821036461446 2848 17018221
SGTC_510 ag-490 170 µM -0.235818317122138 0.411418757967299 no 2000 0.406786826975165 2886 5328779
SGTC_583 1488-1091 88.9 µM -0.23797374963092 0.410634542701459 no 2001 0.405950727077052 2880 4303273
SGTC_1431 4049-0260 9.09 µM -0.238000926394419 0.410624657199192 no 2002 0.405940187843681 2796 3854841
SGTC_2322 7413319 38.22 µM -0.240338504587042 0.409774580148717 no 2003 0.405033923632155 2958 1840400
SGTC_208 k072-0098 12.366 µM -0.240389579212833 0.409756011213413 no 2004 0.405014127989523 2813 5948901
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.243481300461739 0.408632348696424 no 2005 0.403816284692155 2781 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1994 st072947 40.9 µM -0.243743914656734 0.408536938029816 no 2006 0.403714579950207 2938 5286565 YDL195W SEC31
SGTC_1413 3910-0535 34.4 µM -0.244861920007067 0.408130814943395 no 2007 0.403281673826793 2953 2876951
SGTC_3172 9105863 49.47 µM -0.245346951766401 0.4079546545047 no 2008 0.403093900084934 2878 2348785
SGTC_1472 k841-0093 193 µM -0.245415694353988 0.407929689140214 no 2009 0.4030672890924 2941 X1472
SGTC_3339 9145883 14.936 µM -0.246001678505483 0.407716891446564 no 2010 0.402840466582248 2988 2030670
SGTC_951 1171-0579 82.7 µM -0.247415027917803 0.407203751650577 no 2011 0.402293522528423 2789 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1182 1222-0449 220 µM -0.249200257983088 0.40655582212803 no 2012 0.401602939939277 2913 658318
SGTC_2754 granisetron 64.02 µM -0.249682684691371 0.406380774505484 no 2013 0.40141637489462 2995 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_197 4544-0043 41.561 µM -0.250013540858786 0.406260734781239 no 2014 0.401288438507572 2850 896523
SGTC_3308 9128332 17.569 µM -0.250279323104436 0.406164311261153 no 2015 0.40118567275067 3006 17332805 YDL196W YDL196W
SGTC_1480 1070-0044 41.2 µM -0.250509903324116 0.406080663344426 no 2016 0.401096523533779 2930 3124987
SGTC_1476 4112-3294 3.34 µM -0.250723999534447 0.406002999193598 no 2017 0.401013752138687 2965 704369
SGTC_2847 9005661 71.43 µM -0.25105963524168 0.405881253610035 no 2018 0.400884001495714 2922 2991449
SGTC_320 4092-0846 5.34 µM -0.251833955065915 0.405600418297129 no 2019 0.400584705302491 2939 1359356
SGTC_1826 st055655 41.6 µM -0.253233233627564 0.405093042233673 no 2020 0.400043993268772 2919 676168
SGTC_1470 k295-0292 231 µM -0.253678009192645 0.404931800720903 no 2021 0.399872162276637 2955 5045612
SGTC_307 1501-1223 22.3 µM -0.254618175026185 0.404591021829528 no 2022 0.39950901005695 2945 2830329
SGTC_2520 obtusaquinone 4.71 µM -0.255558160436937 0.40425038067304 no 2023 0.399146014425222 3022 5967872
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.255690279845701 0.404202507754358 no 2024 0.399095000648877 2840 4620898
SGTC_3116 9124943 49.47 µM -0.256066055443519 0.404066354872882 no 2025 0.398949916081766 2885 41905195 YPL160W CDC60
SGTC_1850 st056238 17 µM -0.257864772696121 0.403414795916066 no 2026 0.398255636467843 2821 5393177
SGTC_3114 9122766 49.47 µM -0.25897050392337 0.403014393883481 no 2027 0.397828999388491 2913 17176985
SGTC_219 mitoxanthrone 164.414 µM -0.25968701124028 0.402754989989834 no 2028 0.397552606267469 2919 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3219 9131112 49.47 µM -0.261758984736178 0.402005095143409 no 2029 0.396753631095838 2947 17612988 YMR079W SEC14
SGTC_2890 9046729 58.44 µM -0.262293643775508 0.401811648163851 no 2030 0.396547531032526 2896 903329
SGTC_1552 6-methylflavone 10.6 µM -0.263760905423057 0.401280896479133 no 2031 0.395982080493567 2893 689013
SGTC_2775 cyproheptadine 69.59 µM -0.263934624320244 0.401218069283314 no 2032 0.395915147494606 2957 2913 A selective serotonin reuptake inhibitor.
SGTC_1377 2944-0135 198 µM -0.266239124349529 0.400384865821195 no 2033 0.395027526574158 2956 1894137
SGTC_1183 1254-0324 198 µM -0.266931214506963 0.400134725483097 no 2034 0.394761061320611 3023 5799357
SGTC_973 1325-0077 65.9 µM -0.268592194282664 0.399534569214586 no 2035 0.39412175984977 2941 2835149
SGTC_66 0109-0187 42.4 µM -0.270799399203648 0.398737414655518 no 2036 0.393272660992157 2782 759417
SGTC_2899 9053889 58.44 µM -0.271102836602417 0.398627858085867 no 2037 0.393155969978333 2971 6470052
SGTC_934 2950-0684 338 µM -0.272548727091417 0.398105926815329 no 2038 0.392600064973861 3094 1121253
SGTC_1158 4092-0494 91.8 µM -0.2731441202375 0.397891057310336 no 2039 0.392371216338343 3018 1148199
SGTC_3065 9113888 49.47 µM -0.27336370277815 0.397811820691214 no 2040 0.392286825755635 3090 16648368
SGTC_2380 9035439 200 µM -0.273667378802816 0.397702245785378 no 2041 0.392170124475053 3041 6462575
SGTC_629 3448-6466 76.7 µM -0.274179705419867 0.397517402136148 no 2042 0.391973261732262 2926 573744
SGTC_2159 5658611 73.75 µM -0.274697481179074 0.397330615854541 no 2043 0.391774333237576 2981 793844
SGTC_2205 7238770 200 µM -0.276009433125885 0.396857438035816 no 2044 0.391270410488712 3017 279867
SGTC_1016 4226-1401 38 µM -0.276919760519378 0.396529202127975 no 2045 0.390920859512356 2855 2901613
SGTC_2465 5809242 33.21 µM -0.277058007962093 0.396479360781917 no 2046 0.390867782432828 2878 2731748
SGTC_1255 0566-0045 221 µM -0.277853097778682 0.396192745691241 no 2047 0.390562564597555 3037 2788469
SGTC_1724 st037281 8.293 µM -0.279200776255368 0.395707060875934 no 2048 0.390045373975851 2872 574124 YDL195W SEC31
SGTC_3014 9081533 49.47 µM -0.280426488237352 0.395265471670014 no 2049 0.389575158645895 3058 21367265
SGTC_1957 st077035 62.4 µM -0.28079250228625 0.3951336332516 no 2050 0.389434777339854 3002 705593
SGTC_2194 5927483 104.545 µM -0.281076523908425 0.395031336811363 no 2051 0.389325853411556 2895 760979
SGTC_620 0109-0052 432 µM -0.281149469119289 0.395005065206476 no 2052 0.389297879906018 3039 493037
SGTC_3159 9100096 49.47 µM -0.281368827673343 0.394926064935315 no 2053 0.389213762313165 2805 25236875
SGTC_2800 7887935 81.82 µM -0.282825292272107 0.39440164028102 no 2054 0.388655382566643 3085 2961002
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.285255456298135 0.393527045130367 no 2055 0.387724218202084 3029 5024745
SGTC_1621 st003705 32.4 µM -0.285270343953802 0.393521688841306 no 2056 0.387718515692268 3065 24207032
SGTC_2833 9001315 45.46 µM -0.285514884083054 0.393433710941642 no 2057 0.387624851457621 2898 2989378
SGTC_3 0833-0587 95.581 µM -0.287605570894229 0.392681769672941 no 2058 0.386824340015221 2963 5382644
SGTC_1365 1672-3266 55.4 µM -0.288305973343898 0.3924299506974 no 2059 0.38655626756446 3024 6415873
SGTC_1643 st009866 20.2 µM -0.289004121644073 0.392178986981472 no 2060 0.386289111733532 3003 3156273 YOR207C RET1
SGTC_2343 7990716 14.84 µM -0.289177635356584 0.392116620874528 no 2061 0.386222722736955 2903 6456862
SGTC_2441 5730946 39.09 µM -0.289588304847976 0.391969024810297 no 2062 0.386065607592226 3037 1774275
SGTC_1233 0325-0408 14.2 µM -0.289768288402532 0.391904342983705 no 2063 0.385996754840529 3015 12874
SGTC_185 k048-0037 25.491 µM -0.290366086368566 0.391689530002527 no 2064 0.385768092867214 3062 6827589
SGTC_1835 st008666 49.2 µM -0.291111099569449 0.39142186285874 no 2065 0.385483175579833 2916 690455
SGTC_631 k072-0230 41.5 µM -0.291611876471375 0.391241973420573 no 2066 0.385291696914305 3025 5773147
SGTC_1481 3346-2004 36 µM -0.292000719202618 0.391102309097082 no 2067 0.385143037039772 2941 2770522
SGTC_2745 rifampicin 24.3 µM -0.292048820219256 0.391085033175346 no 2068 0.385124648538352 2974 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2360 9040895 200 µM -0.292195798687077 0.39103224584098 no 2069 0.385068461851348 2974 4914414
SGTC_2867 9039098 71.43 µM -0.292674437659553 0.390860356514581 no 2070 0.384885505261416 2898 6463460
SGTC_2564 betulinic acid 100 µM -0.293833931513792 0.390444046321004 no 2071 0.38444240269793 3212 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_170 4197-0004 226 µM -0.294482389274158 0.390211275681818 no 2072 0.384194659230221 3061 218692
SGTC_3233 9132340 49.47 µM -0.294970954344348 0.390035926172952 no 2073 0.3840080340505 2929 17682950
SGTC_298 1391-0729 10 µM -0.2955887554584 0.389814224958305 no 2074 0.38377208097806 2924 3237558
SGTC_2895 9054447 58.44 µM -0.296460760457195 0.389501362344013 no 2075 0.383439114684045 2935 2697450
SGTC_1856 st057054 55.7 µM -0.29787349425811 0.388994646208961 no 2076 0.382899859330876 3165 1266018
SGTC_3077 9117319 49.47 µM -0.298511204865635 0.388765975404764 no 2077 0.382656512746603 2909 17154678
SGTC_834 0312-0008 75.7 µM -0.301168419535577 0.387813564794615 no 2078 0.381643035029913 2935 6385573 YIL048W NEO1
SGTC_634 1611-4317 11.2 µM -0.301923233300329 0.387543143882425 no 2079 0.381355292078402 2972 2843522
SGTC_2749 bexarotene 57.39 µM -0.304538861571141 0.386606487070741 no 2080 0.380358695275291 3038 82146 An retinoic acid receptor inhibitor.
SGTC_2914 7968218 45.32 µM -0.30455022694101 0.386602418567082 no 2081 0.380354366612032 3037 2977111
SGTC_938 3126-1755 342 µM -0.305401300262416 0.386297792132079 no 2082 0.380030265800141 3116 1777771
SGTC_1686 st019653 115.5 µM -0.305945074517959 0.386103194563318 no 2083 0.379823232925327 3076 97252
SGTC_2394 5221648 200 µM -0.306059181229515 0.386062363443339 no 2084 0.379779793089686 3078 788586
SGTC_1282 0886-0010 32.4 µM -0.309265158535399 0.384915677142396 no 2085 0.378559916071125 3121 2836211 YNL267W PIK1
SGTC_1217 1183-1422 255 µM -0.309628375970837 0.384785827910732 no 2086 0.378421787564183 3094 2849664
SGTC_1165 k072-0275 30.3 µM -0.310032384942167 0.38464141099842 no 2087 0.378268164631284 3062 6153523 YGL055W OLE1
SGTC_541 4513-1321 94 µM -0.312156878383766 0.383882254109683 no 2088 0.377460650920278 2962 747515
SGTC_724 3910-0327 137 µM -0.312692549887706 0.383690909868236 no 2089 0.377257128135645 3025 2885483
SGTC_1211 1056-0033 32.3 µM -0.313374710535276 0.383447280108636 no 2090 0.376997997684775 3102 6741922
SGTC_3203 9113543 49.47 µM -0.314010251592986 0.38322034172749 no 2091 0.376756626324678 3105 17018012
SGTC_155 k072-0202 43.6 µM -0.314965239350455 0.382879410991641 no 2092 0.376394023284554 2953 5857737
SGTC_812 4251-0442 148 µM -0.315339425457376 0.382745851232362 no 2093 0.376251976815495 3094 5723007
SGTC_1617 st002906 78 µM -0.315738446573268 0.382603442374408 no 2094 0.376100521082882 2938 5150859
SGTC_1215 3852-0577 11.2 µM -0.316496518725336 0.382332933539086 no 2095 0.375812833565395 3125 2884876
SGTC_1450 4112-4260 37.6 µM -0.317291885699775 0.382049178221534 no 2096 0.375511066900301 3112 1633175
SGTC_2832 7992762 51.95 µM -0.318053481105086 0.381777530622501 no 2097 0.375222184718751 2913 2985177
SGTC_2135 5326629 150.42 µM -0.318334523988778 0.381677302296689 no 2098 0.375115599480851 3007 5020077
SGTC_2357 9067248 200 µM -0.320382815511941 0.380947060052284 no 2099 0.37433907540232 3057 9150235
SGTC_3057 9095946 49.47 µM -0.320599725382575 0.38086975366909 no 2100 0.374256872873783 2925 24540043
SGTC_2793 7325131 81.82 µM -0.320675489027169 0.380842752729508 no 2101 0.374228162004152 3026 4176441
SGTC_1933 st074711 15.9 µM -0.320896201480823 0.380764097682818 no 2102 0.374144526307252 2941 17250958
SGTC_3230 9131665 49.47 µM -0.322050331743215 0.380352881913482 no 2103 0.373707282388361 2958 15943720
SGTC_3053 9095903 49.47 µM -0.322225864959381 0.380290351388816 no 2104 0.373640795598492 3044 17174018
SGTC_264 promethazine 12.5 mM -0.32387505099559 0.379703011750532 no 2105 0.373016316599875 3047 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1017 4239-0030 168 µM -0.325249588977645 0.379213696929758 no 2106 0.372496090259319 2991 1149593
SGTC_1811 st050069 61.5 µM -0.327067528602469 0.378566835026787 no 2107 0.371808405382229 3021 3877702
SGTC_397 arbidol 50 µM -0.330156521449319 0.377468485854675 no 2108 0.370640848677312 3131 131410 A RNA synthesis inhibitor.
SGTC_2488 5268135 45.7 µM -0.330218733902117 0.377446375197085 no 2109 0.370617346226223 3113 1270356 YLR208W SEC13
SGTC_1972 st070201 17.4 µM -0.330827196643135 0.37723014528361 no 2110 0.370387508294134 3123 2829099
SGTC_456 gingerol 170 µM -0.330954219986757 0.377185009745397 no 2111 0.3703395329117 3178 442793 A herb.
SGTC_2334 9017922 200 µM -0.331274510425858 0.377071207553171 no 2112 0.370218571533295 3115 3163164
SGTC_2290 7904846 200 µM -0.332481838629917 0.376642328590399 no 2113 0.369762725569971 3051 2962154
SGTC_343 4130-2827 29.8 µM -0.333155530991662 0.37640307911187 no 2114 0.369508441791452 3031 1118244
SGTC_369 0957-0393 4.5 µM -0.333406756540824 0.376313873117167 no 2115 0.369413631833832 3037 6997992
SGTC_474 dl-dihydrosphingosine 5 µM -0.336768115973141 0.375120947852255 no 2116 0.368145855130533 3142 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1090 efavirenz 20.7 µM -0.337389162600591 0.374900672610593 no 2117 0.367911776611243 3046 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1496 4469-0713 57.4 µM -0.337947844331131 0.374702552053769 no 2118 0.367701245928839 3107 746691
SGTC_2640 pentamidine 10.38 µM -0.338564415336559 0.374483941101475 no 2119 0.36746894669558 3105 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_210 3551-0445 56.827 µM -0.339921745590913 0.374002829351376 no 2120 0.366957730049033 3134 2865180 YOR207C RET1
SGTC_2430 5571206 200 µM -0.340134365667122 0.373927482974959 no 2121 0.36687767145283 3163 1731771
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.340684701806631 0.373732482215541 no 2122 0.36667047831638 3009 390807
SGTC_1802 st050112 57.9 µM -0.34169983071199 0.373372876122914 no 2123 0.366288399760417 3008 4662563
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.341744281457274 0.373357132109223 no 2124 0.36627167222459 3209 551469
SGTC_1267 0828-0272 9.49 µM -0.343864725233766 0.3726063379572 no 2125 0.365474010573027 3144 745334
SGTC_2532 xanthone 78.9 µM -0.344678578511439 0.372318301935657 no 2126 0.365168012116312 3115 7020 An insecticide.
SGTC_56 0957-0365 83.25 µM -0.34516139428873 0.372147459252533 no 2127 0.364986520088807 3133 6752360
SGTC_479 n-linoleoylglycine 10 µM -0.34534237817696 0.372083425215741 no 2128 0.364918495445226 3022 6433346 An anti-infammatory.
SGTC_833 3852-0053 558 µM -0.345381919940076 0.372069435387521 no 2129 0.364903633835387 3179 3123681
SGTC_2716 st080858 38.6235 µM -0.347838149482376 0.371200756061777 no 2130 0.363980868709199 3156 5296050
SGTC_193 1273-0060 1.558 µM -0.347902101405931 0.371178147325959 no 2131 0.363956853526058 3057 2847393 YHR072W ERG7
SGTC_1177 0983-0204 23.6 µM -0.349467320262229 0.370624938869796 no 2132 0.363369250378559 3167 766818
SGTC_300 r073-0011 5.04 µM -0.350264682044845 0.370343223321383 no 2133 0.363070034043478 3129 2735780
SGTC_1984 st072354 53.1 µM -0.351173152093979 0.370022336899198 no 2134 0.362729225290873 2981 5762938
SGTC_2507 purpurin 79.67 µM -0.351221497756202 0.370005262956832 no 2135 0.362711091661552 3002 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_790 1575-0012 79.1 µM -0.351619954498453 0.369864552182285 no 2136 0.362561649096536 3169 378741 YLR208W SEC13
SGTC_406 estrone 100 µM -0.354751409328693 0.368759319929935 no 2137 0.361387916710585 3207 5870 A steroid.
SGTC_1195 1502-0147 41.1 µM -0.3547942810321 0.36874419606938 no 2138 0.361371856551809 3034 817940
SGTC_1530 rhein 70.4 µM -0.355879348710496 0.36836148423537 no 2139 0.360965461005076 3013 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_143 4032-1194 15.74 µM -0.356040894649943 0.368304516880162 no 2140 0.360904969846282 2965 1806963
SGTC_1076 itraconazole 331 nM -0.356116756706419 0.36827776597972 no 2141 0.360876564367362 3077 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1019 4262-0212 3.4 µM -0.356315331999827 0.368207746278655 no 2142 0.360802214278334 3124 4677213
SGTC_2315 7733312 200 µM -0.356733420376489 0.368060338308706 no 2143 0.360645691823254 3025 726316
SGTC_2694 st077685 81.9 µM -0.357194303208452 0.367897864546398 no 2144 0.360473175180793 2982 2838096
SGTC_1379 2144-0755 36.5 µM -0.359351083152231 0.367137855310223 no 2145 0.35966623199978 3219 5392327
SGTC_1737 st035557 69.7 µM -0.359834758108465 0.366967488550612 no 2146 0.359485354315186 3048 5716916
SGTC_1818 st052136 56.3 µM -0.361284881833374 0.36645686281013 no 2147 0.358943247066334 3139 674169
SGTC_1687 st020778 55.3625 µM -0.362377439194601 0.366072301390408 no 2148 0.358534998198202 3061 4259299
SGTC_2685 mycophenolic acid 18.85 µM -0.362395125118422 0.366066077354271 no 2149 0.358528390941028 3069 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1674 st016616 23.6 µM -0.36263073998914 0.365983163054146 no 2150 0.358440371983306 3004 625830
SGTC_2201 6605497 169.863 µM -0.363018038153009 0.365846884084932 no 2151 0.358295704840259 3070 670741
SGTC_1509 1326-1131 80 µM -0.364209276501907 0.365427828088369 no 2152 0.357850870188543 3146 768313
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.365105588019152 0.365112627835098 no 2153 0.357516294895895 2964 4000243
SGTC_1104 tacrolimus 29.8 µM -0.366671345052218 0.364562226581622 no 2154 0.356932091673083 3093 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2353 9059630 146.67 µM -0.369202373964536 0.363673099659798 no 2155 0.355988443259554 3155 4779114
SGTC_1213 1315-0166 115 µM -0.370824490037822 0.363103650827558 no 2156 0.355384129703252 3146 768401
SGTC_1934 st074720 32.6 µM -0.371668040054936 0.362807639474411 no 2157 0.355070011693067 3020 17250992
SGTC_3321 9137793 26.8275 µM -0.371982332625856 0.362697371563375 no 2158 0.354953001765141 3140 4904192
SGTC_3146 9095609 49.47 µM -0.372946728697864 0.362359089331569 no 2159 0.354594046204817 3103 17173999
SGTC_1825 st052143 62.6 µM -0.373329075737391 0.362225002784868 no 2160 0.354451769442495 3223 674173
SGTC_134 0269-0018 6.916 µM -0.373429036413991 0.362189950031548 no 2161 0.354414576003251 3123 4378915
SGTC_2221 6807166 181.081 µM -0.374684135060014 0.361749928764503 no 2162 0.353947696268799 3123 674925
SGTC_3337 9144342 33.5465 µM -0.374954088705099 0.361655310384349 no 2163 0.353847305823111 3161 17682949
SGTC_2346 9031566 143.75 µM -0.37541538236602 0.361493647170565 no 2164 0.353675783312537 3118 4771086
SGTC_2263 7948595 193.29 µM -0.375660944566683 0.361407598461961 no 2165 0.353584488197024 3024 2971371
SGTC_1921 5740136 50 µM -0.375873094651085 0.361333263508261 no 2166 0.353505621818592 3230 1774243
SGTC_1005 4092-0690 4.4 µM -0.37651317306674 0.361109019113893 no 2167 0.353267712042804 3095 1529343
SGTC_1922 5578187 25 µM -0.376611908022377 0.361074432660741 no 2168 0.353231018498423 3262 1350412
SGTC_363 0455-0021 3.06 µM -0.37733883512813 0.36081982803406 no 2169 0.352960907646387 3043 4597466
SGTC_2459 5811157 9.22 µM -0.379626204774141 0.36001908462041 no 2170 0.352111452974386 3088 2870684 YBR192W RIM2
SGTC_1767 st044992 70.3 µM -0.379670702980876 0.360003513132914 no 2171 0.352094935086918 3119 9600693
SGTC_142 0335-0849 62.6745 µM -0.37976330542733 0.359971109024953 no 2172 0.352060561634797 3220 3889043 YPR107C YTH1
SGTC_2097 5376186 200 µM -0.380063861487941 0.359865943240837 no 2173 0.351949005424458 3177 742755
SGTC_743 1275-0778 158 µM -0.380072818985095 0.359862809139015 no 2174 0.351945680900984 3153 2849257 YMR203W TOM40
SGTC_1841 st054148 70 µM -0.380923158997644 0.359565330101481 no 2175 0.351630133672306 3142 675442
SGTC_3262 9137218 49.47 µM -0.381664106616195 0.359306189752941 no 2176 0.351355263478799 3024 17650664
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.38182771278114 0.359248978556431 no 2177 0.35129458078163 3171 368090
SGTC_1381 2324-0066 62.1 µM -0.383954039167652 0.358505714101454 no 2178 0.350506256395164 3189 10885928
SGTC_2942 9052777 62.25 µM -0.383975050637809 0.358498372140501 no 2179 0.350498469707487 3094 6469503
SGTC_304 1310-0298 97 µM -0.388770597227383 0.356824054967023 no 2180 0.348722926576352 3143 1550234
SGTC_1443 4112-3303 14 µM -0.389031730797904 0.356732961582546 no 2181 0.348626336940363 3099 704433
SGTC_989 1501-0895 10.3 µM -0.389087690964398 0.356713441597375 no 2182 0.348605639338069 3216 2830112
SGTC_379 3970-0972 5.9 µM -0.389551794747994 0.356551567713044 no 2183 0.348434001832541 3135 2898042 YBL034C STU1
SGTC_906 1165-0455 526 µM -0.391774519469176 0.355776666369981 no 2184 0.347612411809373 3094 3252859
SGTC_2306 7482397 179.52 µM -0.391801750318654 0.355767176653323 no 2185 0.347602350845243 3251 891448
SGTC_292 k038-0015 474 µM -0.392362689618789 0.355571714027704 no 2186 0.347395124858253 3196 46368540
SGTC_732 3970-1727 52.7 µM -0.393332510079657 0.355233863946744 no 2187 0.347036954842582 3185 1275699
SGTC_1694 st024011 44.9 µM -0.393525697746154 0.355166577987786 no 2188 0.346965623892387 3199 2787533
SGTC_2690 usnic acid 100 µM -0.394482409656896 0.354833428283213 no 2189 0.34661245579158 3340 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_516 3992-2719 87.3 µM -0.394615234791221 0.354787184199198 no 2190 0.346563434213838 3007 5350887 YDR037W KRS1
SGTC_2173 5763948 167 µM -0.395290367507799 0.354552164682696 no 2191 0.346314303707277 3135 2867177
SGTC_1997 st073024 93.8 µM -0.397451434924399 0.35380025110274 no 2192 0.345517296349908 3217 686268
SGTC_1222 0366-0074 1.18 µM -0.398182818287068 0.35354590529167 no 2193 0.345247715061089 3227 286520
SGTC_2395 5646831 180.19 µM -0.398968570390817 0.353272725059096 no 2194 0.344958181416589 3275 6808628
SGTC_380 3970-0968 6 µM -0.39975161702617 0.353000560620323 no 2195 0.344669734965526 3078 2891601
SGTC_223 busulfan 5 mM -0.400006283696815 0.35291206202309 no 2196 0.344575944294676 3184 2478 A DNA alkylator.
SGTC_2883 9059145 45.46 µM -0.400469532123222 0.352751100090034 no 2197 0.344405359971914 3051 16476510
SGTC_3160 9100216 49.47 µM -0.400776413646597 0.352644484463553 no 2198 0.34429237285122 3156 17191039
SGTC_2305 7443522 69.23 µM -0.400809855260551 0.35263286700277 no 2199 0.344280061213764 3096 5415886
SGTC_1108 betulinic acid 729.144 nM -0.403395907135985 0.351734901649991 no 2200 0.343328498600946 3161 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_805 3852-0218 479 µM -0.404258053779064 0.351435718406194 no 2201 0.343011483724515 3087 6615355
SGTC_902 1120-0002 2.07 µM -0.404786854312032 0.351252258877516 no 2202 0.342817096233067 3105 3280475
SGTC_325 2810-4341 181 µM -0.40729993316432 0.350380857663974 no 2203 0.341893855937017 3233 774970
SGTC_821 1114-0266 29.2 µM -0.409354856600589 0.349668904752084 no 2204 0.341139631822142 3203 3123235
SGTC_2572 astragaloside iv 100 µM -0.40980999008687 0.349511289673799 no 2205 0.340972668638442 3266 45006101 An anti-inflammatory agent.
SGTC_2300 7976697 71.57 µM -0.409946487360283 0.349464025018032 no 2206 0.340922601442587 3072 2236109
SGTC_2127 5253358 187.912 µM -0.41013429245827 0.34939899791252 no 2207 0.340853719117364 3053 20612
SGTC_3049 9092223 49.47 µM -0.415166306408923 0.34765832525461 no 2208 0.339010081200562 3214 8623917
SGTC_1529 apigenin 74 µM -0.419009882335949 0.346330914454585 no 2209 0.337604455020347 3354 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1388 3346-4487 254 µM -0.419118281816557 0.346293505056028 no 2210 0.337564845186714 3212 3345614
SGTC_104 0074-0074 590.992 µM -0.41930356819687 0.346229564937362 no 2211 0.337497144576347 3154 3943124
SGTC_1281 0884-0031 11.8 µM -0.420421683529289 0.345843809760841 no 2212 0.337088715238581 3162 1548255
SGTC_1385 3091-4834 14.1 µM -0.421073935472298 0.345618853546272 no 2213 0.336850546836423 3238 4072814
SGTC_2499 avocadenofuran 51.48 µM -0.421316724415713 0.345535131595649 no 2214 0.33676190967205 3093 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1519 esterone 74 µM -0.422658250709796 0.345072663649575 no 2215 0.336272310051825 3106 698 A steroid.
SGTC_2449 5812982 45.77 µM -0.423073812444114 0.344929452832182 no 2216 0.336120704089433 3232 776185
SGTC_1666 st014829 29 µM -0.424625840754481 0.344394789619794 no 2217 0.335554726213774 3139 3858230
SGTC_3035 9091303 49.47 µM -0.42465277091074 0.344385515104018 no 2218 0.335544908886575 3201 25237002
SGTC_1175 0741-0056 27.6 µM -0.424818325216457 0.344328501671195 no 2219 0.33548455890784 3328 765927
SGTC_1064 honokiol 6.76 µM -0.427433509288458 0.343428357115648 no 2220 0.334531802419602 3227 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_8 0354-0001 70 µM -0.427670095160936 0.343346968114492 no 2221 0.334445662544276 3177 4993152
SGTC_650 1328-0195 38 µM -0.429523674780141 0.342709561275981 no 2222 0.333771084292886 3260 2780821
SGTC_2624 nerol 100 µM -0.430274001329175 0.342451666987547 no 2223 0.333498168457414 3164 637566 A natural product oil.
SGTC_3276 9139060 49.47 µM -0.430301495492946 0.342442218379067 no 2224 0.333488169693776 3199 4870619
SGTC_83 0170-0301 39.027 µM -0.430435021934526 0.342396332258606 no 2225 0.333439612004066 3228 3089716
SGTC_126 0417-1624 672.48 µM -0.431329927088936 0.342088859789815 no 2226 0.333114246451901 3298 41912 YDL195W SEC31
SGTC_3107 9121808 49.47 µM -0.431419946667128 0.34205793655813 no 2227 0.333081524489662 3249 662681
SGTC_44 0929-0055 61.211 µM -0.431695559534753 0.341963265512889 no 2228 0.33298134758751 3117 1379590
SGTC_2238 6671620 73.2395 µM -0.432963255497852 0.341527949057864 no 2229 0.332520732204976 3109 729941
SGTC_2340 7987427 183.45 µM -0.434585993121954 0.340971021741221 no 2230 0.331931481900367 3274 2239331
SGTC_3261 9137475 49.47 µM -0.435341796854083 0.340711746295775 no 2231 0.331657175321622 3182 17027690
SGTC_2197 6588183 93.1375 µM -0.435588643947606 0.340627082681527 no 2232 0.33156760575751 3157 884136
SGTC_184 1494-0393 24.714 µM -0.435761459401238 0.340567815216444 no 2233 0.331504904633544 3115 3090647
SGTC_2828 7998861 71.43 µM -0.436673294932699 0.340255164294063 no 2234 0.331174149516412 3256 2988188
SGTC_983 1491-0821 12.2 µM -0.437405429661414 0.340004208782696 no 2235 0.330908673554067 3277 46495113
SGTC_662 k832-1615 104 µM -0.43885554232807 0.339507359612959 no 2236 0.330383105982069 3246 5878478
SGTC_2975 9084847 53.72 µM -0.438877530296709 0.339499828063518 no 2237 0.330375139404614 3239 27211724
SGTC_3013 9080133 71.4286 µM -0.439437846780882 0.339307924226263 no 2238 0.33017215411876 3380 17050193
SGTC_420 mitomycin C 81.9 mM -0.439583898704827 0.33925790947509 no 2239 0.330119252244716 3169 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_84 0443-0269 128.823 µM -0.439804377197093 0.339182413082232 no 2240 0.330039398549779 3287 6150058
SGTC_2406 ethylparaben 405.7 µM -0.440563191404146 0.338922628777513 no 2241 0.32976462768636 3044 8434 A possible steroid mimic.
SGTC_216 k038-0035 28.382 µM -0.44083784894928 0.338828617095435 no 2242 0.329665195285867 3243 4444231 YPR107C YTH1
SGTC_1186 1319-0216 26 µM -0.442428975645109 0.338284192941963 no 2243 0.329089407592728 3338 4565136
SGTC_2569 tetrandrine 100 µM -0.443029955692819 0.33807864786617 no 2244 0.328872033782281 3181 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_313 3474-0040 5.03 µM -0.443037556441676 0.338076048593771 no 2245 0.328869284970363 3141 1043375 YIL048W NEO1
SGTC_783 0848-0141 92.7 µM -0.444286823611199 0.337648934395335 no 2246 0.328417613202324 3231 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_390 dec-rvkr-cmk 16.7 µM -0.44752800113798 0.336541778153523 no 2247 0.327246937501857 3249 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2384 9036245 200 µM -0.44816385795274 0.336324741147236 no 2248 0.327017472190572 3210 6462766
SGTC_1886 st057356 49.9 µM -0.448501551492932 0.336209498378419 no 2249 0.32689563335466 3174 24207747
SGTC_425 3825-7017 13.1 µM -0.450265027932767 0.335607936977692 no 2250 0.326259676270996 3367 3397440
SGTC_1344 1488-0097 29.1 µM -0.450626211669471 0.33548478100232 no 2251 0.326129485918552 3293 747966
SGTC_519 k048-0011 62.8 µM -0.45180822527797 0.335081863115359 no 2252 0.325703571835769 3260 6836379
SGTC_319 1348-1596 45.5 µM -0.452352691886932 0.334896332308886 no 2253 0.32550746105595 3350 5380505
SGTC_347 4534-1311 26.2 µM -0.45266115155861 0.334791240392364 no 2254 0.325396378761568 3229 2862016
SGTC_1960 st011366 51.8 µM -0.453103082924335 0.334640697344836 no 2255 0.325237257757744 3223 3972846
SGTC_1564 D-Arginine 115 µM -0.454590145598908 0.334134327682059 no 2256 0.324702062786412 3234 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1974 st069448 26.9 µM -0.45599465107048 0.333656347179774 no 2257 0.324196912309017 3313 6323587 YNR016C ACC1
SGTC_866 0495-0101 262 µM -0.458031741774299 0.332963565306643 no 2258 0.32346481843969 3199 635694
SGTC_2068 5226020 147 µM -0.462782501550348 0.331350125105814 no 2259 0.321760137561497 3248 1810509
SGTC_127 0180-0333 59.125 µM -0.462849935466602 0.33132724580832 no 2260 0.321735967611149 3294 771601
SGTC_3153 9100258 49.47 µM -0.464376269299792 0.330809552590112 no 2261 0.321189094508472 3200 25236848
SGTC_2210 7115885 190.385 µM -0.46474913551452 0.330683135066552 no 2262 0.321055558403344 3256 2927039
SGTC_547 1120-0019 610 nM -0.466269452795529 0.330167882795967 no 2263 0.320511320611096 3238 3676939
SGTC_2147 5545932 89.7195 µM -0.468268070253765 0.329491019177873 no 2264 0.319796449516922 3278 797404
SGTC_2391 6285546 200 µM -0.469200807737204 0.329175323702085 no 2265 0.319463054093117 3212 846083
SGTC_147 4466-0538 29.23 µM -0.469414482838089 0.32910302010019 no 2266 0.319386699111736 3409 6742687 YHR072W ERG7
SGTC_557 1315-0110 16.2 µM -0.469730890378171 0.328995965531459 no 2267 0.319273647633341 3206 6833801
SGTC_2022 5136654 200 µM -0.4704768191119 0.328743640594935 no 2268 0.31900719601137 3324 1713771
SGTC_1113 artemisinin 1.17947 µM -0.47102288266 0.328558973427759 no 2269 0.318812197075104 3317 2240 An anti-malaria and mitochondrial poison.
SGTC_623 k072-0108 16.9 µM -0.471324132386675 0.328457115043833 no 2270 0.318704642455889 3279 5382803
SGTC_681 1642-0006 26.6 µM -0.47246018470948 0.328073108422014 no 2271 0.318299177285296 3327 4446530
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.474296155517645 0.327452900571454 no 2272 0.317644366325349 3253 689007
SGTC_865 0488-0499 301 µM -0.474854514066427 0.327264376208577 no 2273 0.317445337055395 3382 9634651
SGTC_2072 5231554 129 µM -0.476115729461503 0.326838701230299 no 2274 0.316995965753376 3377 789545
SGTC_3003 9075612 71.4286 µM -0.476328209075672 0.326767009026903 no 2275 0.31692028576026 3288 6501993
SGTC_2474 5321570 43.32 µM -0.476884043279411 0.326579496681358 no 2276 0.31672234756988 3301 2841384
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.477678129238877 0.326311685388913 no 2277 0.316439656536746 3265 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1132 3456-3614 2.5 µM -0.477697683198646 0.326305091801964 no 2278 0.316432696766866 3420 3125502
SGTC_2584 androsterone 48.74 µM -0.478182357013945 0.326141677349389 no 2279 0.316260209357136 3330 2754130 A steroid.
SGTC_2984 9022109 38.96 µM -0.478194843326996 0.326137467857864 no 2280 0.316255766212458 3368 6459207
SGTC_2855 9016525 58.44 µM -0.47883336565129 0.325922233350657 no 2281 0.316028589037807 3271 43811474
SGTC_508 roscovitine 141 µM -0.479670722447479 0.325640063185525 no 2282 0.315730774646979 3313 160355 A CDKinase inhibitor.
SGTC_1452 4194-0072 190 µM -0.479733948183293 0.325618761606302 no 2283 0.315708292630278 3378 1343545
SGTC_2864 9034755 47.6 µM -0.481935506024592 0.324877383461109 no 2284 0.314925881149369 3354 4930451
SGTC_3108 9121785 49.47 µM -0.481943387190148 0.324874730709178 no 2285 0.31492308175119 3331 17140271
SGTC_1392 3455-1037 33.9 µM -0.482145848146497 0.324806586639055 no 2286 0.314851171054993 3377 981132
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.482853896394079 0.324568318707039 no 2287 0.314599739545329 3289 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1427 4048-4900 550 nM -0.483658399156327 0.324297679629789 no 2288 0.314314160860746 3362 24132586
SGTC_2207 7258803 200 µM -0.48605777574048 0.323491067917175 no 2289 0.31346310154547 3333 3666799
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.48684094165626 0.323227965905289 no 2290 0.313185527000097 3365 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_287 k060-0039 29.6 µM -0.487216637369524 0.323101783531171 no 2291 0.3130524081307 3372 5861974
SGTC_1511 0906-3109 28.5 µM -0.487262678770772 0.323086321317347 no 2292 0.313036096127273 3329 2882180
SGTC_1482 3346-2049 8.48 µM -0.48808789011007 0.322809240124311 no 2293 0.312743794167717 3340 3826804
SGTC_1347 1493-0251 600 nM -0.489097914423719 0.322470238127109 no 2294 0.312386188960476 3360 3986378
SGTC_1416 3966-0321 25.3 µM -0.491441441445189 0.321684231411427 no 2295 0.311557129844897 3297 582530 YLR208W SEC13
SGTC_1067 clotrimazole 1.36 µM -0.491897501122384 0.321531363963477 no 2296 0.311395902459906 3275 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2182 6325192 200 µM -0.49202195929222 0.321489651857185 no 2297 0.31135190996925 3347 736248
SGTC_858 0438-0351 2.77 µM -0.49396660313086 0.320838197859521 no 2298 0.310664882833897 3306 2799119
SGTC_1719 st032227 49.2 µM -0.494478299379814 0.320666871590464 no 2299 0.310484214177114 3258 3125804
SGTC_499 genistein 192 µM -0.494967247670688 0.320503197482881 no 2300 0.310311620026679 3353 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2647 atorvastatin 60.16 µM -0.495793433530321 0.320226713341185 no 2301 0.310020079109308 3329 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1781 st038725 66.3 µM -0.500305512558503 0.318718504180506 no 2302 0.308429986563763 3255 4270275 YIL048W NEO1
SGTC_1029 k015-0030 64.7 µM -0.500606836024404 0.318617890208559 no 2303 0.308323925224605 3361 2208316
SGTC_1977 st070720 65.3 µM -0.502896732012348 0.317853715601548 no 2304 0.30751843944178 3385 682188
SGTC_1912 st060209 90.8 µM -0.504637161030503 0.317273425024403 no 2305 0.3069068521297 3301 688787
SGTC_1272 0839-0021 27 µM -0.50493248208987 0.317175004141999 no 2306 0.306803129459213 3345 5027250
SGTC_1488 4013-0813 75.9 µM -0.504997219250879 0.317153431084075 no 2307 0.306780394538228 3286 2910057
SGTC_95 0471-0001 561.058 µM -0.505746050412099 0.316903935230059 no 2308 0.306517467980781 3306 4015405
SGTC_1298 1079-1278 263 µM -0.506921099260393 0.316512599816949 no 2309 0.306105090321494 3361 2840950
SGTC_683 panaxydol 45 µM -0.507123765514263 0.316445125089407 no 2310 0.306033990405981 3367 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_468 gf-109203x 121 µM -0.507741101276101 0.316239629946755 no 2311 0.305817460065553 3319 2396 A protein kinase C inhibitor.
SGTC_391 gliotoxin 8.33 µM -0.508189797997178 0.316090305992349 no 2312 0.305660122402348 3440 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_737 1950-0117 57.9 µM -0.509090061292819 0.315790793495082 no 2313 0.305344548963696 3396 5393513
SGTC_2489 cantharidin 73.42 µM -0.509890559209259 0.315524573922925 no 2314 0.30506406818751 3395 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2442 5158906 48.48 µM -0.510804500456445 0.315220743813688 no 2315 0.304743978756433 3378 1893835
SGTC_221 trifluoperazine 10.304 µM -0.511215364213182 0.31508419719547 no 2316 0.304600130703639 3379 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2985 9022375 71.43 µM -0.512757792596599 0.314571811531093 no 2317 0.304060378802733 3457 4939335
SGTC_178 4092-0806 87.505 µM -0.51304658301934 0.314475916685317 no 2318 0.303959367907833 3385 2169044
SGTC_2518 prenyletin 46.28 µM -0.514499954341257 0.313993504839638 no 2319 0.303451246148555 3363 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1641 st009299 47.1 µM -0.514882813174264 0.313866476843918 no 2320 0.303317455776006 3367 4046054
SGTC_57 miconazole 162.5 nM -0.516038201344646 0.313483266594849 no 2321 0.302913864245484 3349 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1246 0422-0085 105 µM -0.51730303108239 0.313063988330434 no 2322 0.302472319239995 3430 264295
SGTC_1459 k035-0031 35.7 µM -0.518092755798602 0.312802325057899 no 2323 0.302196777170968 3280 3877128 YMR208W ERG12
SGTC_192 3455-0609 60.9 µM -0.518349449567713 0.312717293781798 no 2324 0.30210723866888 3423 3769639
SGTC_1010 4112-3296 15.2 µM -0.518588049721763 0.312638265055655 no 2325 0.302024022164493 3441 704384
SGTC_1989 st071868 50.2 µM -0.519011395226972 0.312498066498003 no 2326 0.3018763974223 3397 16414057
SGTC_1646 st011709 75.6 µM -0.520330164160696 0.312061506179577 no 2327 0.301416737687544 3401 5757843
SGTC_3260 9137109 49.47 µM -0.521964289778077 0.311520917382541 no 2328 0.30084759719251 3323 17478346
SGTC_2070 5230947 200 µM -0.52198974037258 0.311512501222093 no 2329 0.300838736981619 3437 2835538
SGTC_1072 oxiconazole 14.9 nM -0.522295087629107 0.311411534777297 no 2330 0.300732444475152 3402 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3016 9080866 49.47 µM -0.52355058692289 0.310996539171434 no 2331 0.300295578747588 3304 17066299
SGTC_2031 5180455 200 µM -0.523777690092268 0.310921497612773 no 2332 0.300216586176977 3351 29949
SGTC_801 0866-0028 10.1 µM -0.523831341975325 0.310903770602489 no 2333 0.300197925985652 3343 6849771
SGTC_3333 9141820 12.094 µM -0.524445482320004 0.310700885001258 no 2334 0.299984364582421 3289 1939433
SGTC_59 0330-0160 1.33 µM -0.531090599604942 0.308509314312362 no 2335 0.297677999036041 3417 4293482
SGTC_918 glabranin 770.725 nM -0.531188714661296 0.308477006600688 no 2336 0.297644006273577 3373 124049 Also referred to as licorice root.
SGTC_1701 st028638 40.4 µM -0.531368902967384 0.30841767734918 no 2337 0.297581583177991 3432 3490878
SGTC_490 phenamil 164 µM -0.531605173902628 0.308339889772217 no 2338 0.297499740290239 3348 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2517 totarol 10 µM -0.532812317643819 0.307942595688975 no 2339 0.297081753156141 3383 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2287 7945887 168.79 µM -0.533600150580293 0.307683426118276 no 2340 0.296809102027178 3385 1245853
SGTC_2006 4011487 200 µM -0.535354178946169 0.307106756657918 no 2341 0.296202484311136 3467 45595294
SGTC_253 dyclonine 31.25 µM -0.53538647270361 0.307096143949888 no 2342 0.296191321088104 3429 3180 An oral anasthetic.
SGTC_767 0929-0023 86 µM -0.536271576846449 0.30680533482129 no 2343 0.295885435729938 3455 1204563
SGTC_283 0987-0079 11.7 µM -0.537785113347135 0.306308330140995 no 2344 0.295362705288914 3433 411556
SGTC_3207 9114163 49.47 µM -0.538193740169484 0.306174209106142 no 2345 0.295221650628898 3540 849233
SGTC_2403 6032726 181.2 µM -0.53828963486746 0.30614273794948 no 2346 0.295188553051054 3362 2881040
SGTC_2052 5265182 7.135 µM -0.538906178588598 0.305940432011931 no 2347 0.294975796865485 3425 1239884
SGTC_825 1988-2224 89.6 µM -0.539177403254654 0.305851454048371 no 2348 0.294882225356879 3335 1180859
SGTC_3277 9138724 49.47 µM -0.541041046328874 0.305240377387134 no 2349 0.294239645647693 3330 15943418
SGTC_1587 estradiol valerate 56.1 µM -0.541495527763333 0.30509143803439 no 2350 0.29408303968701 3452 13791 A steroid.
SGTC_2099 5377090 177.372 µM -0.541804039972864 0.304990353044534 no 2351 0.293976753998905 3399 2243829
SGTC_86 0417-1630 471.922 µM -0.541884612117743 0.304963955779403 no 2352 0.293948998976191 3426 3634867
SGTC_1708 st033234 31.827 µM -0.544091779641956 0.304241232639228 no 2353 0.29318915847648 3488 674664
SGTC_130 0136-0219 337.655 µM -0.546857419886569 0.303336719644215 no 2354 0.292238345471062 3390 234244
SGTC_842 0271-0008 11.1 µM -0.547370828805467 0.303168939681775 no 2355 0.292061996086453 3481 1221709
SGTC_449 xestospongin c 11.1929 µM -0.547616766088048 0.303088583074886 no 2356 0.291977537332991 3427 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2382 9035899 200 µM -0.548577662334326 0.302774714888558 no 2357 0.29164765942818 3385 6462679
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.54967109790796 0.302417731095962 no 2358 0.291272491940382 3433 140250 A respiratory chain inhibitor.
SGTC_1044 1222-0021 1.78 µM -0.550377411625245 0.302187234865526 no 2359 0.291030269226208 3401 4306703
SGTC_2990 9074105 71.4286 µM -0.550799411899207 0.302049558243914 no 2360 0.290885593679652 3414 6502001
SGTC_2415 st077333 57.7 µM -0.552217038330293 0.301587267262583 no 2361 0.290399831106473 3543 2766255
SGTC_1 0258-0098 57.368 µM -0.552284749777491 0.301565194382428 no 2362 0.290376638670395 3368 6790032 YDR047W HEM12
SGTC_3029 9088683 49.47 µM -0.552301806337414 0.301559634323396 no 2363 0.290370796616612 3458 25236615
SGTC_1703 st026983 48.3 µM -0.553667857313835 0.301114481945723 no 2364 0.289903088388092 3489 1104023
SGTC_1721 st082152 9.2685 µM -0.554952563457604 0.300696107648176 no 2365 0.289463553628136 3425 5296051
SGTC_2960 9079389 5.97 µM -0.556880758662627 0.300068669138968 no 2366 0.288804450898046 3467 16457355
SGTC_2626 ethyl orsellinate 100 µM -0.557177867929437 0.299972041881241 no 2367 0.288702954774186 3379 75653 A natural product.
SGTC_266 formosanin C 406 nM -0.558761136072094 0.299457361662244 no 2368 0.288162374660929 3409 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1791 st048313 56.1 µM -0.559190196275956 0.299317954077384 no 2369 0.288015961600481 3431 1204976
SGTC_429 1112-0049 25.5 µM -0.559566654391733 0.299195661888576 no 2370 0.287887527473018 3300 2836170
SGTC_3292 9120825 59.784 µM -0.560015726253324 0.299049810832471 no 2371 0.287734355500177 3512 24824900
SGTC_561 1550-0330 72.9 µM -0.560101891338816 0.299021829540457 no 2372 0.287704970228459 3371 6812934
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.561610375632661 0.298532156334303 no 2373 0.287190754826645 3439 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2450 5739737 12.93 µM -0.563146027302378 0.298034039276195 no 2374 0.286667725838427 3463 2262825
SGTC_228 caffeine 993.056 µM -0.563351367583138 0.297967462072584 no 2375 0.286597823057895 3480 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1159 4092-0538 61.2 µM -0.563540343429759 0.297906196678591 no 2376 0.286533498269986 3479 717301
SGTC_2396 5342950 42.78 µM -0.564814017827535 0.297493425203398 no 2377 0.286100135707729 3428 1886677
SGTC_640 3381-0960 37.1 µM -0.565694298931916 0.297208297044846 no 2378 0.285800805718928 3476 1745025
SGTC_3345 9148410 3.559 µM -0.566219980737815 0.297038085247481 no 2379 0.285622124411279 3471 4903596
SGTC_1325 1431-0015 227 µM -0.566895257305 0.296819501240342 no 2380 0.285392673291253 3377 1103340
SGTC_77 0828-0286 12.516 µM -0.567309959698736 0.29668530042989 no 2381 0.285251805765215 3455 745345
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.567948374340661 0.296478758985789 no 2382 0.285035011676986 3471 17037758
SGTC_2671 danthron 100 µM -0.568911047904519 0.296167437172946 no 2383 0.284708253738204 3432 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1840 st055363 71 µM -0.569333717281756 0.296030796287122 no 2384 0.28456484461054 3412 676033
SGTC_1362 1611-0397 101 µM -0.571284426103523 0.295400544899491 no 2385 0.283903428455987 3438 27816
SGTC_2018 5133068 143 µM -0.571527440107091 0.295322073153847 no 2386 0.283821082597441 3452 785362
SGTC_1507 4075-3230 155 µM -0.571630064588624 0.295288937523981 no 2387 0.283786311488221 3418 659771
SGTC_696 1560-0013 611 µM -0.572375958433714 0.295048153024261 no 2388 0.283533649894316 3549 1650269
SGTC_393 acivicin 6.25 µM -0.574834989532508 0.294254986205473 no 2389 0.282701450251858 3390 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2272 7805186 180 µM -0.574958739043819 0.294215096524391 no 2390 0.282659601259612 3482 2956062 YPR165W RHO1
SGTC_999 SEC7.066 22.7 µM -0.575801980796822 0.293943350714543 no 2391 0.282374517263067 3459 740511 YDR170C SEC7
SGTC_1101 ebselen 5.29 µM -0.577987989551929 0.293239421486553 no 2392 0.281636114004787 3543 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_565 1418-0001 44.5 µM -0.578655135505712 0.293024745733775 no 2393 0.281410946997191 3527 2862145
SGTC_3106 9121286 49.47 µM -0.579341219300704 0.292804052193478 no 2394 0.281179478963765 3551 15943471
SGTC_318 1488-0629 67.2 µM -0.580706950237467 0.292364965462574 no 2395 0.280718988339827 3485 3662576
SGTC_2808 7946468 45.46 µM -0.582062013062931 0.29192961140217 no 2396 0.280262455536268 3453 2970879
SGTC_305 1682-2595 20.8 µM -0.582279435247254 0.291859786203178 no 2397 0.280189237550152 3474 226033
SGTC_1326 1431-2094 10.8 µM -0.58380830183723 0.29136901007562 no 2398 0.279674646105131 3446 616278
SGTC_381 3461-2219 42.7 µM -0.58524799393195 0.290907211886676 no 2399 0.27919048903521 3487 2883159
SGTC_2839 9003951 25.97 µM -0.58589441116602 0.290699977281582 no 2400 0.278973236636094 3494 2990634
SGTC_1268 0828-0275 2.46 µM -0.586576883284742 0.290481258816181 no 2401 0.278743955937367 3505 745337
SGTC_3025 9087895 49.47 µM -0.586787753431739 0.290413694792182 no 2402 0.278673131371135 3505 17173641
SGTC_804 1595-0054 20.9 µM -0.587439957160346 0.29020477149733 no 2403 0.27845413238595 3420 761523 Stimulates phospholipase C.
SGTC_2105 5350118 200 µM -0.58877446984935 0.289777500753274 no 2404 0.27800628709136 3491 2133313
SGTC_1271 0832-2808 169 µM -0.590674006745308 0.289169835854411 no 2405 0.277369433730338 3539 3663794
SGTC_2368 9071271 200 µM -0.590777125753151 0.289136865070529 no 2406 0.277334881681248 3453 27209959
SGTC_3054 9094397 49.47 µM -0.590875674777255 0.289105357123654 no 2407 0.277301862861975 3444 2598354
SGTC_2513 baicalein 25.65 µM -0.591203738546744 0.289000480701087 no 2408 0.277191959054566 3455 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2589 lobaric acid 100 µM -0.592034882815813 0.288734858118653 no 2409 0.276913614950557 3437 73157 A novel microtubule depolymerizer.
SGTC_2001 4023502 57.655 µM -0.592908497813598 0.288455786439522 no 2410 0.276621195318452 3485 108941 YCR052W RSC6
SGTC_2714 st079313 56.9 µM -0.594643845427326 0.287901816241049 no 2411 0.276040782654216 3500 2939799
SGTC_2256 7954252 200 µM -0.594796249123503 0.287853188839768 no 2412 0.275989837563762 3454 2972920
SGTC_3338 9144300 39.5675 µM -0.59507545529007 0.287764112676806 no 2413 0.275896517270679 3453 4901274
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.596021038796722 0.287462536490407 no 2414 0.275580585969136 3472 6708561
SGTC_1258 0671-0043 57.1 µM -0.596263220050689 0.287385321355379 no 2415 0.275499698802817 3472 4298767
SGTC_1338 1486-1223 76 µM -0.597269905784867 0.287064462921621 no 2416 0.275163596684598 3492 3444526
SGTC_998 3996-0085 177 µM -0.597786175190675 0.286899979495803 no 2417 0.274991308199015 3484 715391
SGTC_2178 5812956 200 µM -0.598038145599456 0.286819717946102 no 2418 0.274907240396633 3493 5403383
SGTC_2037 5169046 200 µM -0.600556116625522 0.286018239609447 no 2419 0.274067836930966 3509 5718022
SGTC_2434 5670830 169.91 µM -0.600866033098288 0.285919665801401 no 2420 0.273964609214748 3495 1549830
SGTC_1150 3909-7983 10.9 µM -0.602111822941765 0.28552358577854 no 2421 0.273549852557391 3449 23965914
SGTC_2400 5203494 178.7 µM -0.6036735137435 0.285027439068975 no 2422 0.273030363379828 3516 6777674
SGTC_594 1487-1584 10.8 µM -0.604517888567651 0.284759353845996 no 2423 0.272749689860676 3446 5013332
SGTC_2836 9010338 19.48 µM -0.605052011738321 0.284589834292844 no 2424 0.272572219163255 3413 2994051
SGTC_682 0kpi-0099 17 µM -0.605293080797501 0.284513339788027 no 2425 0.27249213901351 3542 1714895 YML126C ERG13
SGTC_1230 0170-0365 3.77 µM -0.606523053890288 0.284123205484065 no 2426 0.272083739168735 3606 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3162 9099653 49.47 µM -0.607333865801074 0.283866164622548 no 2427 0.271814683992026 3507 25237511
SGTC_53 0973-0023 39.979 µM -0.609631923609585 0.283138247512036 no 2428 0.271052829771491 3550 674768
SGTC_907 3448-6986 75.5 µM -0.611259582478172 0.282623223821443 no 2429 0.270513871918374 3581 590582
SGTC_1502 4534-4282 27.7 µM -0.612225554526583 0.282317784083585 no 2430 0.270194268197596 3500 3278949
SGTC_3227 9130768 49.47 µM -0.612389585255505 0.282265933451731 no 2431 0.27014001537786 3541 17720899
SGTC_3309 9129340 25.759 µM -0.612915958301915 0.282099576222556 no 2432 0.269965955402592 3521 17158987
SGTC_617 3770-0098 35 µM -0.613924811780602 0.281780865783039 no 2433 0.269632506728953 3510 5962639
SGTC_346 4513-0042 7.16 µM -0.614167032206077 0.281704370923508 no 2434 0.269552478180333 3551 2827372
SGTC_1613 st002381 52.1 µM -0.614579130805859 0.281574250390185 no 2435 0.269416349997683 3549 551167
SGTC_1264 0783-0040 158 µM -0.614734472455585 0.281525208637625 no 2436 0.269365045067253 3493 2855798
SGTC_531 3788-1495 174 µM -0.615620161210641 0.281245673198699 no 2437 0.269072620870252 3515 2896655
SGTC_2868 9035608 32.47 µM -0.616117045174465 0.281088908553273 no 2438 0.268908636533139 3548 6462614
SGTC_678 1218-2179 85.9 µM -0.616157637881534 0.281076103602923 no 2439 0.268895242125539 3520 6820081 YOR116C RPO31
SGTC_1976 st070609 63.5 µM -0.61708616815699 0.28078327613876 no 2440 0.268588945760637 3515 682556
SGTC_1080 nisoldipine 24.4 µM -0.617322181107111 0.280708869050623 no 2441 0.268511119598752 3498 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2644 guaiazulene 100 µM -0.617545511571593 0.280638469114643 no 2442 0.268437485974973 3535 3515 A coloring agent.
SGTC_364 0083-0097 67.7 µM -0.61916310388144 0.280128814454509 no 2443 0.267904457701476 3555 5207356
SGTC_3042 9091578 49.47 µM -0.619208586217102 0.280114490824624 no 2444 0.2678894780916 3527 25236497
SGTC_2259 7964009 200 µM -0.619651726350156 0.279974952471001 no 2445 0.26774355194479 3571 313134
SGTC_504 lovastatin 124 µM -0.619834253085042 0.279917487270124 no 2446 0.267683457498221 3493 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2785 7756463 72.73 µM -0.620233590964725 0.27979178299899 no 2447 0.267552004638615 3506 2201551
SGTC_871 0574-0004 149 µM -0.620351407832996 0.279754701633055 no 2448 0.267513228249666 3481 9551173
SGTC_3280 9140961 49.47 µM -0.620640166774789 0.279663828501194 no 2449 0.267418202663611 3495 4901226
SGTC_376 3970-0862 59.1 µM -0.624639738592636 0.278406629264769 no 2450 0.266103766089341 3546 3135186
SGTC_691 1548-0686 185 µM -0.627144403274332 0.27762073425915 no 2451 0.265282291495435 3514 46495133
SGTC_773 4358-1457 44.6 µM -0.629626737388549 0.276842916879344 no 2452 0.264469412980265 3600 1186886
SGTC_73 0327-0325 16.231 µM -0.629733061888117 0.276809624892137 no 2453 0.264434623716976 3605 53298
SGTC_2236 dapsone 200 µM -0.63034044118763 0.276619481835419 no 2454 0.264235934520921 3587 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1336 1486-0901 104 µM -0.633246772105168 0.275710527766036 no 2455 0.26328625328593 3522 5006114
SGTC_438 sphingosine 6.67 µM -0.634132566643283 0.275433788010859 no 2456 0.262997155446916 3411 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_279 1273-0055 2.93 µM -0.634438145413083 0.275338350865245 no 2457 0.262897460988547 3598 2847562
SGTC_820 1582-0060 59.9 µM -0.635156730467403 0.275113989390465 no 2458 0.262663100228798 3524 3848840
SGTC_463 ikarugamyin 104 µM -0.63533402505521 0.275058647128575 no 2459 0.262605293463933 3598 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1140 3229-1848 2.98 µM -0.636291069807116 0.274760001651469 no 2460 0.262293362217545 3569 2849525
SGTC_3174 9107204 49.47 µM -0.637542449531803 0.274369750382405 no 2461 0.261885784370564 3617 3938802
SGTC_665 3914-0008 307 µM -0.639510504900281 0.273756553016158 no 2462 0.261245440998223 3551 1069549
SGTC_1288 0973-0013 65.5 µM -0.639962064025795 0.273615954025415 no 2463 0.261098631396224 3594 4315430
SGTC_602 3130-1533 38.1 µM -0.640339493284833 0.273498463782745 no 2464 0.260975955227192 3599 720941
SGTC_3194 9111903 49.47 µM -0.641833243631304 0.273033718230781 no 2465 0.260490731152581 3603 17087251
SGTC_1768 st044301 37.178 µM -0.643938920945485 0.27237925147561 no 2466 0.259807520960972 3570 3931349
SGTC_861 0443-0273 110 µM -0.644923842183096 0.272073395266751 no 2467 0.259488270092089 3580 6149169
SGTC_3145 9085516 49.47 µM -0.644924332704199 0.272073242983496 no 2468 0.259488111145818 3574 25236195
SGTC_1842 st055362 61.2 µM -0.645572311595395 0.271872113656531 no 2469 0.259278186869133 3591 676032
SGTC_475 α-linolenic acid 10 µM -0.645722330287614 0.271825559171056 no 2470 0.25922959816222 3686 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_259 usnic acid 108.925 µM -0.64572570397265 0.27182451227932 no 2471 0.259228505532538 3656 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1094 duloxetine 25.4 µM -0.645750354460414 0.271816863021539 no 2472 0.25922052209288 3601 60834 A selective serotonin reuptake inhibitor.
SGTC_2728 chlorpromazine 9.18 µM -0.645842824298555 0.271788169792202 no 2473 0.259190575445841 3586 2726 A thorazine and dopamine antagonist.
SGTC_1909 st060837 51.5 µM -0.646087204531263 0.271712346289044 no 2474 0.259111440750212 3538 678937
SGTC_579 4491-1009 110 µM -0.646269210543675 0.271655882387424 no 2475 0.259052512061334 3716 1271041
SGTC_1065 prochlorperazine maleate 2.48 µM -0.647560910718403 0.271255324911537 no 2476 0.258634493233974 3626 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2268 7933382 153.85 µM -0.647811114899648 0.271177770403206 no 2477 0.258553562780304 3620 935025 YOR257W CDC31
SGTC_1036 k216-0215 33.5 µM -0.649380827541715 0.270691467011942 no 2478 0.258046126629674 3597 622330
SGTC_2055 5235184 200 µM -0.649410629172744 0.270682238558871 no 2479 0.258036497747079 3604 2836034
SGTC_630 4356-0227 183 µM -0.652288159980985 0.269791915277655 no 2480 0.257107648317369 3610 779312
SGTC_1902 st060212 70.5 µM -0.653216066923958 0.269505128940537 no 2481 0.256808496786809 3632 688944
SGTC_3302 9125395 16.351 µM -0.653348414847365 0.269464236886821 no 2482 0.256765843392259 3560 17599668
SGTC_828 2074-0507 139 µM -0.655103960616213 0.268922113468137 no 2483 0.256200411128097 3650 X828
SGTC_2598 perillyl alcohol 100 µM -0.655745434504448 0.26872415904629 no 2484 0.255993965067829 3607 10819 An apoptosis inducer.
SGTC_326 k292-0812 17.5 µM -0.656079264526684 0.268621170370525 no 2485 0.255886562627144 3572 3579357
SGTC_2531 methyl deoxycholate 70.07 µM -0.656211380114307 0.268580417354207 no 2486 0.25584406384893 3577 16667744 Haematoxylin.
SGTC_137 0438-0332 85.389 µM -0.656608409730656 0.268457966372824 no 2487 0.255716370029049 3631 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_540 1187-0821 17.3 µM -0.65692022352198 0.268361817147655 no 2488 0.255616106905318 3604 847520
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.657501657197459 0.26818257565331 no 2489 0.255429202879061 3579 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.657776978697689 0.268097721926742 no 2490 0.255340724675405 3679 688801
SGTC_2852 9023854 51.95 µM -0.658215321829546 0.267962653037386 no 2491 0.255199890377784 3657 19798528
SGTC_2601 securinine 100 µM -0.659978353298363 0.267419747514925 no 2492 0.254633860363978 3571 442872 A GABA receptor antagonist.
SGTC_1473 k844-0725 134 µM -0.663809158994303 0.266242009975149 no 2493 0.253406231450238 3683 54682906
SGTC_1946 st076057 65.1 µM -0.664313688084731 0.266087094152395 no 2494 0.253244781018104 3523 953009
SGTC_1352 1496-0991 99 µM -0.665101796152067 0.265845196692548 no 2495 0.252992692955088 3616 3000039
SGTC_3311 9131146 2.8755 µM -0.665165473085987 0.265825656919662 no 2496 0.252972330709436 3603 4900406 YPR165W RHO1
SGTC_357 1325-0123 420 µM -0.666272906427558 0.265485948655262 no 2497 0.252618339977986 3606 1098503
SGTC_2025 5147754 141 µM -0.669830606736648 0.26439610656308 no 2498 0.251482890083072 3635 315777 YLR208W SEC13
SGTC_3051 9093778 49.47 µM -0.670130179811092 0.264304441412711 no 2499 0.251387403764426 3634 17217378
SGTC_1408 3909-7976 48.8 µM -0.671414244089064 0.263911719194697 no 2500 0.250978336627078 3661 24152374
SGTC_2546 rhodinyl acetate 100 µM -0.671836274185684 0.263782709174345 no 2501 0.250843966538397 3615 6708682
SGTC_771 0250-0039 27.3 µM -0.672294658186348 0.263642622603639 no 2502 0.250698064893617 3619 3005115
SGTC_1930 st074634 34.3 µM -0.672946869216401 0.263443366064064 no 2503 0.250490546436331 3603 684253 YOR116C RPO31
SGTC_1028 k015-0029 4.8 µM -0.673175217174467 0.263373621810836 no 2504 0.250417912919536 3628 4588309
SGTC_1723 st034307 2.5525 µM -0.674119522244318 0.26308530311223 no 2505 0.250117664457612 3660 867466
SGTC_2495 cafestol 54.53 µM -0.674242760437962 0.263047687475053 no 2506 0.25007849409609 3641 16667697 An anti-infammatory.
SGTC_1770 st043884 66.3 µM -0.675581394249828 0.26263927730532 no 2507 0.249653228842836 3632 670149
SGTC_2642 cholecalciferol 100 µM -0.676140926939945 0.262468663015236 no 2508 0.249475587025835 3619 9821465 A vitamin D precursor, similar to steriods.
SGTC_1287 0971-0001 34.6 µM -0.67638725182658 0.262393570926189 no 2509 0.24939740449372 3646 4665869
SGTC_1013 4112-3890 241 µM -0.676488967147978 0.262362566241734 no 2510 0.24936512425776 3597 705171
SGTC_2997 9067075 71.4286 µM -0.676793750521528 0.262269673947255 no 2511 0.2492684119208 3632 27209819
SGTC_2536 dehydroabietamide 32.04 µM -0.679810158838467 0.261351238223438 no 2512 0.248312336698076 3657 3983547
SGTC_673 1082-0474 110 µM -0.680452475439963 0.261155879284215 no 2513 0.248109001978887 3669 3098046
SGTC_2095 5432005 200 µM -0.681097560784501 0.26095975380237 no 2514 0.247904880200217 3654 783734
SGTC_1812 st052057 4.327 µM -0.681361615362231 0.260879495065935 no 2515 0.247821352325507 3643 3645418
SGTC_1572 epiandrosterone 68.9 µM -0.683360051090407 0.260272487384694 no 2516 0.247189678449421 3606 441302 A steroid.
SGTC_837 0091-0265 12.5 µM -0.683989295625389 0.260081510524249 no 2517 0.246990962606843 3615 759367
SGTC_2686 alizarin 95.37 µM -0.685588894800919 0.259596354734475 no 2518 0.246486193192739 3633 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.685694023465157 0.259564485755373 no 2519 0.246453038166208 3602 641818 YHR062C RPP1
SGTC_1463 k081-0032 34.1 µM -0.68622104978297 0.259404752068018 no 2520 0.246286862896019 3510 977755
SGTC_2302 7771753 200 µM -0.686374954910662 0.259358115338453 no 2521 0.246238346813035 3643 2203047
SGTC_813 k007-0158 173 µM -0.687381371243962 0.259053255276608 no 2522 0.245921216822598 3668 6523916
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.687760806999255 0.25893836606505 no 2523 0.245801710442836 3657 688669
SGTC_2192 5915882 198.485 µM -0.689375810520195 0.25844965475417 no 2524 0.245293400864808 3618 2876149
SGTC_1722 st034304 3.6505 µM -0.689532235432205 0.258402344880378 no 2525 0.245244197395237 3674 4036148 YLR033W RSC58
SGTC_310 1273-0058 1.06 µM -0.690502618300617 0.258108958080056 no 2526 0.244939081977183 3669 2734232
SGTC_2711 st079103 59.1 µM -0.690932769875185 0.257978960777238 no 2527 0.244803895702225 3654 54693780
SGTC_963 1269-2853 151 µM -0.690991717332368 0.257961148748783 no 2528 0.24478537306632 3653 3668223
SGTC_1756 st041558 35.5 µM -0.691230690695527 0.257888945209405 no 2529 0.244710289912881 3724 3955792
SGTC_827 3253-0474 693 µM -0.691361034703113 0.257849567421471 no 2530 0.244669342294511 3668 5402065
SGTC_1324 1418-0026 34.4 µM -0.692784717584021 0.257419666639962 no 2531 0.244222332117809 3696 1372513
SGTC_570 0987-0065 62.6 µM -0.693360843829172 0.257245803237449 no 2532 0.244041564318267 3543 3104428
SGTC_653 0203-0016 55.2 µM -0.694766072071064 0.256821989565226 no 2533 0.243600956842863 3690 295302
SGTC_3214 9129694 49.47 µM -0.696256418370745 0.256372901896359 no 2534 0.243134130533126 3639 17158655
SGTC_2388 9080168 200 µM -0.697001862323002 0.256148430100396 no 2535 0.242900814167437 3641 15943073
SGTC_1000 4048-0884 8.67 µM -0.698448549550832 0.255713089076124 no 2536 0.242448361687164 3661 13040088
SGTC_458 nppb 133 µM -0.700310988653908 0.255153208205546 no 2537 0.241866555363214 3707 4549 A chloride channel blocker.
SGTC_157 1348-1695 65.819 µM -0.700998969488708 0.254946551730236 no 2538 0.241651829161093 3684 5380510
SGTC_1417 3966-0327 90.4 µM -0.701048726729269 0.254931608990042 no 2539 0.241636303406357 3719 651118
SGTC_2966 9084041 48.03 µM -0.701067052967598 0.254926105500126 no 2540 0.241630585205584 3622 17741380
SGTC_1171 0368-0077 21.4 µM -0.701469087738224 0.254805387458743 no 2541 0.241505159751704 3655 3239779
SGTC_258 haloperidol 50.781 µM -0.701504148638039 0.254794861223104 no 2542 0.241494223246737 3688 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3047 9092122 49.47 µM -0.703618786900782 0.254160410464065 no 2543 0.240835104238629 3649 17173831
SGTC_2383 9036125 200 µM -0.705291929397027 0.253659008557053 no 2544 0.240314290951406 3639 79580
SGTC_1358 1509-0022 2.48 µM -0.70616851182184 0.25339652472022 no 2545 0.240041674840859 3700 3258434
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.70656657412348 0.253277376096994 no 2546 0.239917933621974 3752 6710655
SGTC_900 1112-0045 141 µM -0.706882803217283 0.253182742915223 no 2547 0.239819655788477 3608 56211 YIL048W NEO1
SGTC_1691 st019933 84.6 µM -0.708967019032903 0.252559496075514 no 2548 0.239172471886253 3664 6176082
SGTC_3200 9114385 49.47 µM -0.709151162552484 0.252504470191613 no 2549 0.239115338164253 3671 17018030 YLR208W SEC13
SGTC_472 calcifediol 10 µM -0.709154074348578 0.252503600137585 no 2550 0.239114434788907 3704 5283731 A vitamin D metabolite.
SGTC_116 0155-0182 31.788 µM -0.709916774966611 0.252275757150744 no 2551 0.238877873629929 3661 771486
SGTC_3028 9087778 49.47 µM -0.713721254693277 0.251140858690288 no 2552 0.237699780355776 3675 17217395
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.714376449331211 0.250945683256821 no 2553 0.237497215335024 3748 4213774
SGTC_46 0329-0187a 2.197 µM -0.714810083646121 0.250816552419503 no 2554 0.237363201735839 3724 46494817
SGTC_2027 5150920 200 µM -0.717355941774399 0.250059138035644 no 2555 0.23657724877148 3678 786715
SGTC_1348 1493-0373 93.8 µM -0.719341402960211 0.249469289781901 no 2556 0.23596529577201 3699 3010129
SGTC_1506 4226-2149 212 µM -0.720144986207895 0.24923076861539 no 2557 0.235717865922158 3737 991114
SGTC_1226 3909-7979 35.4 µM -0.720663644237842 0.249076883935116 no 2558 0.23555824288194 3720 6615510
SGTC_3298 9116858 71.43 µM -0.723219694321422 0.248319248544096 no 2559 0.2347724605212 3726 2506942
SGTC_1475 4092-1048 11.7 µM -0.72394286662691 0.248105117195875 no 2560 0.234550405757313 3714 2881759
SGTC_740 k014-0057 261 µM -0.724085430232009 0.248062915732521 no 2561 0.234506644386885 3732 4012779
SGTC_1953 st076800 12.1 µM -0.727093331713601 0.247173414738688 no 2562 0.233584391703757 3738 297591
SGTC_136 0097-0015 404.482 µM -0.727982832399192 0.246910697486757 no 2563 0.233312047724016 3724 4861337
SGTC_2553 4-methylesculetin 85.09 µM -0.729201296265387 0.246551062475217 no 2564 0.232939269205941 3770 5319502
SGTC_1114 scopoletin 1.73284 µM -0.729354134017967 0.246505971550733 no 2565 0.232892533175756 3723 5280460 A coumarin with genotoxic properties.
SGTC_2012 4023501 200 µM -0.729796319420823 0.246375540786202 no 2566 0.232757347296488 3722 3477460
SGTC_626 0214-0009 33 µM -0.730346368940201 0.246213345143468 no 2567 0.232589245843072 3756 3437874
SGTC_2473 5854593 8.94 µM -0.731169965097973 0.245970594626273 no 2568 0.232337671633405 3654 2872951
SGTC_1759 st043059 70 µM -0.731339467309431 0.245920650704823 no 2569 0.232285914580549 3725 669426
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.73191808389436 0.245750202008771 no 2570 0.232109283867929 3748 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_945 3381-0768 11.3 µM -0.732731687098813 0.2455106383641 no 2571 0.231861046760345 3726 1126236 YIL048W NEO1
SGTC_1949 st076024 69.1 µM -0.732968907153744 0.245440813080217 no 2572 0.231788696800441 3704 2921930
SGTC_2250 alverine citrate 130 µM -0.733249297970631 0.245358294325245 no 2573 0.231703196371591 3660 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_764 1951-2361 146 µM -0.733957612403939 0.24514990447944 no 2574 0.231487286177667 3710 5438930
SGTC_1936 st074407 74.3 µM -0.733965688133998 0.245147529105928 no 2575 0.231484825160149 3774 809813
SGTC_2658 polymyxin b sulfate 77.05 µM -0.734456273033398 0.24500325300076 no 2576 0.231335350492448 3738 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.734701145250323 0.24493125562925 no 2577 0.231260761343767 3677 756377
SGTC_578 3460-0051 92 µM -0.735325435065959 0.244747753352036 no 2578 0.23107066064987 3799 2876744
SGTC_3055 9094636 49.47 µM -0.736096516886705 0.24452120558225 no 2579 0.230835981179752 3741 25236176
SGTC_2707 st078556 66.6 µM -0.737056383094108 0.244239349907652 no 2580 0.230544031072131 3716 17250899
SGTC_849 0386-0493 241 µM -0.737984014049091 0.243967126324466 no 2581 0.230262081733469 3709 726119
SGTC_3046 9092212 49.47 µM -0.738481975596812 0.243821061539362 no 2582 0.230110808099039 3752 25236637
SGTC_1232 0279-0259 161 µM -0.739782800748207 0.243439719236402 no 2583 0.229715898385632 3762 1560000
SGTC_891 0929-0073 133 µM -0.740251147177511 0.243302500468082 no 2584 0.229573808883263 3779 5603632
SGTC_375 3970-0961 9.27 µM -0.740797775419055 0.243142399137272 no 2585 0.229408032107 3725 2898222
SGTC_165 k038-0023 64.381 µM -0.741428384941864 0.242957771410879 no 2586 0.229216869576981 3751 46368543
SGTC_1371 2421-0008 32.7 µM -0.741462850570383 0.242947682866857 no 2587 0.229206424265482 3726 2827552
SGTC_3082 9117008 49.47 µM -0.741968522431618 0.242799692102075 no 2588 0.229053203721787 3806 41448529
SGTC_2143 5623677 140.463 µM -0.742129360415832 0.242752631220156 no 2589 0.229004481233289 3701 5375313
SGTC_2128 5255449 168.493 µM -0.743761072789301 0.242275474591485 no 2590 0.228510517105914 3751 736008
SGTC_937 3122-0005 46.7 µM -0.74512612456448 0.24187668752743 no 2591 0.228097738686681 3762 759535
SGTC_2133 5320837 200 µM -0.74535685478368 0.241809317062456 no 2592 0.228028009556113 3728 2841355
SGTC_1735 st034310 56.75 µM -0.746001169411885 0.241621238828124 no 2593 0.22783335431014 3870 871153
SGTC_1235 benzylparaben 21.5 µM -0.747025866089102 0.241322289091882 no 2594 0.227523973734805 3741 7180
SGTC_646 4092-0839 27.3 µM -0.747132811627196 0.241291099893753 no 2595 0.227491697944843 3787 877796
SGTC_3206 9114350 49.47 µM -0.752008714003782 0.239871439067025 no 2596 0.226022909228324 3687 17087243
SGTC_2370 9071495 200 µM -0.752334678396263 0.239776694482946 no 2597 0.225924909129756 3754 21791103
SGTC_1630 st005209 31.3 µM -0.752911651947418 0.239609041818104 no 2598 0.225751502885689 3735 3367314
SGTC_1660 st012960 28.1 µM -0.757735655619834 0.238209825919474 no 2599 0.224304624555291 3763 24207266
SGTC_3349 9149703 23.001 µM -0.758520440757446 0.237982620892892 no 2600 0.224069740418548 3741 4910494
SGTC_466 geldanamycin 89.2 µM -0.762392644747431 0.236863310921974 no 2601 0.222912847401615 3656 5288382 HSP90 inhibitor.
SGTC_2407 paclitaxel 400 µM -0.762550809948397 0.23681765286377 no 2602 0.222865665047869 3955 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2414 st077232 92.9 µM -0.762863301099996 0.23672745926422 no 2603 0.222772462357051 3748 729801
SGTC_739 1486-1183 203 µM -0.763319839750324 0.236595723538917 no 2604 0.222636336421516 3741 4346692
SGTC_835 0312-0010 67.2 µM -0.765606619870943 0.235936473027173 no 2605 0.221955202182181 3744 1626196
SGTC_2330 7979373 200 µM -0.76564292857892 0.235926013845838 no 2606 0.221944396972226 3749 1863007
SGTC_3310 9130229 44.1445 µM -0.766349729143483 0.235722461942881 no 2607 0.221734118058628 3854 7761258
SGTC_3258 9138477 49.47 µM -0.76802937874128 0.235239127451832 no 2608 0.221234865553285 3827 4970355
SGTC_160 3453-0671 289.699 µM -0.769323067153467 0.234867230169006 no 2609 0.220850773393906 3812 5322268
SGTC_220 paclitaxel 373.376 µM -0.77012595447724 0.234636587244869 no 2610 0.220612590716927 3716 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_700 3453-2283 142 µM -0.770578059821545 0.234506767504053 no 2611 0.220478534992 3835 565664
SGTC_2826 7992541 19.48 µM -0.77281414582866 0.233865271449275 no 2612 0.219816190207261 3845 2985066
SGTC_1711 st032263 62.8 µM -0.77342607389767 0.23368988903143 no 2613 0.219635131948752 3798 3958979
SGTC_1448 4255-0083 152 µM -0.77369516456166 0.233612789049041 no 2614 0.219555540089777 3852 5399660
SGTC_1227 3909-8010 46.6 µM -0.775176516849315 0.233188603944976 no 2615 0.219117681216218 3785 15982272
SGTC_3118 9124250 49.47 µM -0.775577085999739 0.23307397448211 no 2616 0.218999367076998 3761 1504786
SGTC_16 erodoxin 22.806 µM -0.776833450209474 0.232714648202695 no 2617 0.218628519396936 3821 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1198 1612-1005 86.7 µM -0.777354468593787 0.232565724770903 no 2618 0.218474833747447 3853 6998509
SGTC_554 4483-2211 187 µM -0.777455975380069 0.232536717108978 no 2619 0.218444899366531 3838 747107
SGTC_3290 9121031 71.43 µM -0.777465466224921 0.232534005006769 no 2620 0.218442100634371 3793 17014854
SGTC_615 k087-0205 167 µM -0.777977503834147 0.232387711300551 no 2621 0.218291137723058 3796 9642773
SGTC_1240 0356-0016 42.1 µM -0.778710462349594 0.23217838764441 no 2622 0.218075145827875 3800 4305613
SGTC_1656 st012921 11 µM -0.781502155541933 0.231382077226997 no 2623 0.217253604714639 3735 6732821
SGTC_1591 genipin 88.4 µM -0.782447333664328 0.231112817489059 no 2624 0.21697586272143 3834 442424 A DNA cross-linking agent.
SGTC_327 1273-0057 3.96 µM -0.783624638611717 0.230777674788681 no 2625 0.216630197088481 3719 3108138
SGTC_37 0566-0070 1.56 µM -0.783731678133626 0.23074721737921 no 2626 0.216598785280626 3817 1626686
SGTC_1490 4089-0339 670 nM -0.783750071668532 0.230741983842893 no 2627 0.216593387780934 3757 742542
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.784154074788547 0.230627049035228 no 2628 0.216474854515949 3760 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1406 3909-7906 11.9 µM -0.784560642900435 0.230511416814251 no 2629 0.216355606594093 3824 X1406
SGTC_2950 9072895 21.46 µM -0.784794397567228 0.230444949217165 no 2630 0.216287062709345 3749 17332245
SGTC_981 1488-1094 54.9 µM -0.78718005734672 0.229767205372323 no 2631 0.215588234869156 3786 3449522
SGTC_451 chloral hydrate 100 µM -0.789569201442108 0.229089591738695 no 2632 0.214889700375221 3891 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_394 menadione 8.33 µM -0.791768485241964 0.228466818777764 no 2633 0.214247840625042 3772 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1073 triclabendazole 3.09 µM -0.791923355715781 0.228422999858219 no 2634 0.214202683837564 3896 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_233 rapamycin 362 pM -0.793030148403963 0.228109982380915 no 2635 0.213880128926646 3825 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_274 sirtinol 40.1 µM -0.793642598230468 0.227936876154611 no 2636 0.213701763004321 3881 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_750 4073-0104 132 µM -0.793799190998696 0.227892627769812 no 2637 0.213656171853363 3663 22330957
SGTC_3037 9091026 49.47 µM -0.794211417563721 0.227776168108251 no 2638 0.213536181378214 3826 25236398 YIL048W NEO1
SGTC_3071 9117417 49.47 µM -0.796274755389524 0.227193750530335 no 2639 0.212936177647778 3759 45595590 YGL055W OLE1
SGTC_2845 9003024 42.97 µM -0.796401214417379 0.227158082308047 no 2640 0.212899436300906 3853 2990173
SGTC_2898 9056270 58.44 µM -0.797970022203699 0.226715857000856 no 2641 0.212443943363015 3783 19154699
SGTC_3183 9108214 49.47 µM -0.798378850199581 0.226600693868091 no 2642 0.212325336450565 3769 4974831
SGTC_92 0063-0024 660.874 µM -0.800223965640058 0.226081352614355 no 2643 0.211790523442 3911 3594437
SGTC_1892 st058411 7.36 µM -0.801594011942569 0.225696163814056 no 2644 0.211393921286787 3827 3934738
SGTC_3119 9125183 49.47 µM -0.802309735982348 0.225495085588288 no 2645 0.211186905981635 3674 22695334
SGTC_2045 5106652 78.05 µM -0.802982420723388 0.225306191459589 no 2646 0.210992447655583 3817 673349
SGTC_581 0958-0271 211 µM -0.80319810595613 0.225245644659376 no 2647 0.210930120041605 3848 4591145
SGTC_67 0335-0847 266 µM -0.805516354037558 0.224595452031511 no 2648 0.210260886457633 4008 4552207 YOR254C SEC63
SGTC_1881 5652484 16 µM -0.806038802267811 0.224449069571876 no 2649 0.210110238063165 3789 2255129
SGTC_1430 4049-0248 69.1 µM -0.806907470032536 0.224205801284917 no 2650 0.209859897378403 3840 22774488
SGTC_3122 9126309 49.47 µM -0.809608537299536 0.223450331316352 no 2651 0.20908259991016 3880 17591206
SGTC_62 0180-0423 3.232 µM -0.812903474043082 0.222530724010012 no 2652 0.20813670127925 3814 30102 YGL099W LSG1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.813086952541659 0.222479579200954 no 2653 0.208084103266187 3895 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2421 5690543 90.72 µM -0.814008258824611 0.222222865544715 no 2654 0.207820109857107 3904 3397993
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.815241290982438 0.221879556933657 no 2655 0.207467103428778 3905 65057 A dermal irritant. YDR527W RBA50
SGTC_1931 st074438 57.1 µM -0.818756451902361 0.220902507981488 no 2656 0.206462690698467 3837 2787313
SGTC_3176 9106582 49.47 µM -0.81897803047373 0.220841002223154 no 2657 0.206399474097678 3776 17018027
SGTC_2725 haloperidol 53.21 µM -0.819183146425539 0.220784074897749 no 2658 0.206340964523685 3811 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_917 harmaline 728.087 nM -0.819616013135397 0.22066396582763 no 2659 0.206217521033778 3870 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_780 0109-0199 192 µM -0.821071920185706 0.220260264862213 no 2660 0.205802651657911 3927 610414
SGTC_2367 9070478 135.38 µM -0.821299931736858 0.220197079090318 no 2661 0.205737723292328 3821 572802
SGTC_1602 st001878 87.6 µM -0.824472867769187 0.219318885464166 no 2662 0.204835463091636 3882 595405 YLR310C CDC25
SGTC_2235 salicylic acid 500 µM -0.824548255593945 0.219298044407497 no 2663 0.204814054369399 3856 338 A COX inhibitor and kinase inhibitor.
SGTC_3315 9136395 68.55 µM -0.82537293073132 0.219070136292963 no 2664 0.204579949071886 3856 16876844
SGTC_1266 0828-0227 32.9 µM -0.826544494707348 0.218746595910047 no 2665 0.204247644339066 3907 3913820
SGTC_776 4476-4378 112 µM -0.826556093215331 0.218743394228741 no 2666 0.20424435612283 3940 2892008
SGTC_173 1273-0061 2.693 µM -0.82955137397486 0.21791747260646 no 2667 0.203396239540643 3874 2847414 YPL266W DIM1
SGTC_2529 gangaleoidin 93.61 µM -0.830209178293422 0.217736330131083 no 2668 0.20321026341221 3898 4565183
SGTC_3068 9116768 49.47 µM -0.830288921358247 0.217714376836812 no 2669 0.2031877251479 3830 41904888
SGTC_1168 k815-0004 80.5 µM -0.831136712945534 0.217481058480818 no 2670 0.202948200960951 3846 642433
SGTC_497 capsazepine 133 µM -0.83140338533046 0.217407698170318 no 2671 0.202872893636463 3863 2733484 A calcium channel blocker.
SGTC_2662 daunorubicin 22.37 µM -0.832912611173895 0.216992786613787 no 2672 0.202447008327406 3760 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1006 4099-6547 255 µM -0.834127665304517 0.216659080586268 no 2673 0.202104523470152 3917 3146833
SGTC_3215 9129942 49.47 µM -0.835344237587358 0.216325255191963 no 2674 0.201761958280983 3837 17682944
SGTC_2478 5763493 32.33 µM -0.836552580171381 0.215993982931728 no 2675 0.201422054863289 3832 1365576 YLR208W SEC13
SGTC_1945 st075991 56.6 µM -0.836562334009834 0.215991310071701 no 2676 0.201419312532608 3907 1084980
SGTC_1458 k015-0034 6.33 µM -0.839622408358664 0.215153699444156 no 2677 0.200560065526843 3919 3598957
SGTC_1131 3454-3128 32.3 µM -0.840309835433914 0.214965795015397 no 2678 0.200367344117808 3963 710982
SGTC_539 4859-0462 2.54 µM -0.8408210549515 0.214826117771021 no 2679 0.200224094969219 3939 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3149 9097855 49.47 µM -0.840989542527687 0.214780094541157 no 2680 0.200176896445216 3906 25236625 YMR079W SEC14
SGTC_608 k048-0125 159 µM -0.841545625991536 0.214628238202999 no 2681 0.200021167917141 3921 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_262 fenpropimorph 62.5 µM -0.842388877528509 0.214398080561478 no 2682 0.199785158353462 3855 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1987 st072290 61.9 µM -0.843506927108923 0.214093140776693 no 2683 0.199472496624225 3916 54697379
SGTC_387 norethindrone acetate 66.7 µM -0.843806989863415 0.214011343852507 no 2684 0.199388634458379 3890 541197
SGTC_1027 k015-0025 8.67 µM -0.843953960216151 0.213971286461629 no 2685 0.199347566622922 3885 3598955
SGTC_1682 st012968 530 nM -0.845290966374993 0.213607080287867 no 2686 0.198974201778691 3903 24207270
SGTC_2123 5259487 200 µM -0.847820659467038 0.21291897018674 no 2687 0.198268927844893 3905 2173474
SGTC_3017 9080681 49.47 µM -0.848023574206941 0.21286383078444 no 2688 0.198212421021519 3931 16451914
SGTC_2983 9022671 12.99 µM -0.852369870673699 0.211684784577156 no 2689 0.197004418591969 3941 6405161
SGTC_883 0850-0245 24.6 µM -0.853385665418596 0.211409775848213 no 2690 0.196722734050799 4002 6823229 YPR165W RHO1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.853673433299439 0.211331905760034 no 2691 0.196642979061144 3939 688664
SGTC_1202 1988-0068 29.6 µM -0.853916861377381 0.211266047157437 no 2692 0.196575528161505 3863 2850480
SGTC_100 0086-0128 49.5915 µM -0.85449328780497 0.21111014498894 no 2693 0.196415863456803 3969 93297
SGTC_1565 sinapyl alcohol 95.1 µM -0.854758362372158 0.211038474696951 no 2694 0.196342466682519 3949 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1383 3049-0032 20.7 µM -0.855097523154869 0.210946793935345 no 2695 0.196248580347181 3987 712864
SGTC_2349 9023730 187.07 µM -0.858445109817089 0.210043139419729 no 2696 0.195323363847244 3924 4126287
SGTC_3113 9123498 49.47 µM -0.861038874133985 0.209344539739502 no 2697 0.194608316506721 3967 8897275
SGTC_2352 9027995 87.8 µM -0.861284056665506 0.209278573543326 no 2698 0.194540807238788 3874 2997347
SGTC_2292 7671323 168.05 µM -0.861668930914009 0.209175048064497 no 2699 0.19443486359989 3971 937504
SGTC_330 1488-0319 80.1 µM -0.863597621755897 0.208656713065005 no 2700 0.193904485539423 3966 6846614
SGTC_177 1327-0068 8.361 µM -0.86368644671406 0.208632859639282 no 2701 0.193880080482642 3914 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_721 1187-1332 279 µM -0.864010912451775 0.208545739914671 no 2702 0.19379094797247 3862 25730
SGTC_2447 5741742 33.78 µM -0.864395083923957 0.208442616813855 no 2703 0.193685446274292 3972 1776504
SGTC_984 1492-0255 2.91 µM -0.865856303217652 0.208050656717779 no 2704 0.193284484253965 3895 1585198
SGTC_3091 9116372 49.47 µM -0.866907016747021 0.207769080517989 no 2705 0.192996479315025 4009 17169793
SGTC_2910 7948405 25.97 µM -0.867187900065551 0.207693845952624 no 2706 0.192919532446466 3810 2971328
SGTC_2309 7664088 163.95 µM -0.868306530605317 0.207394380609862 no 2707 0.192613274005798 3938 704922
SGTC_1860 st056228 74.6 µM -0.868531976897602 0.207334057957085 no 2708 0.192551587362765 3919 688679
SGTC_3352 9151559 45.5865 µM -0.869042146332692 0.207197590253076 no 2709 0.192412039327455 3918 17159339
SGTC_1689 st020265 53.493 µM -0.869195463051221 0.207156589202205 no 2710 0.192370114275131 3912 5758320 YPR016C TIF6
SGTC_770 0389-1121 67.2 µM -0.869388682177612 0.207104924000497 no 2711 0.192317285711229 4065 6753108
SGTC_3125 9127534 49.47 µM -0.870143208729943 0.206903242835934 no 2712 0.192111073553516 3804 1639235
SGTC_1996 st072960 66.8 µM -0.873621835581018 0.2059749277309 no 2713 0.191162115410209 3934 1719405
SGTC_1421 4029-0249 71.4 µM -0.873804278583009 0.205926308809265 no 2714 0.191112424997075 4001 2894095
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.874560621953613 0.205724824786742 no 2715 0.190906510823266 3731 88881 An O-methylated flavonoid and antioxidant.
SGTC_1340 1486-1359 257 µM -0.876126192446259 0.205308140820896 no 2716 0.190480717542853 3876 4309068
SGTC_3089 9117425 49.47 µM -0.876127756494605 0.205307724792893 no 2717 0.19048029245534 3918 9401657
SGTC_2439 5492030 7.2 µM -0.877145289918592 0.205037172817773 no 2718 0.190203863892371 3922 5722370
SGTC_1483 3453-0561 55.9 µM -0.877179216635199 0.205028155694917 no 2719 0.190194651427337 3951 4546991
SGTC_2769 toremifene 3.73 µM -0.877570526933229 0.204924169359285 no 2720 0.190088414795822 3929 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_879 0831-1030 162 µM -0.877653197428266 0.204902204612483 no 2721 0.190065975292568 3970 1549252
SGTC_2461 5755302 26.15 µM -0.878986818705092 0.204548067873212 no 2722 0.189704211418539 3988 2788904
SGTC_2318 6029776 164 µM -0.880674767155874 0.204100363862523 no 2723 0.189246938931956 3940 818325
SGTC_1041 0206-0046 107 µM -0.880932423274879 0.204032075675625 no 2724 0.18917719853011 3967 50494
SGTC_138 0850-0259 40.9225 µM -0.881003777322623 0.204013166680301 no 2725 0.189157887756795 3919 6813004
SGTC_559 1550-0661 158 µM -0.881409917267118 0.20390555849803 no 2726 0.189047995928537 3992 5830875
SGTC_2650 prasterone 100 µM -0.882608490698524 0.203588189588549 no 2727 0.188723919733837 3909 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2994 9053520 71.4286 µM -0.884870085752208 0.202990147345756 no 2728 0.188113351854012 4008 4647384
SGTC_1905 st060207 84.5 µM -0.88552098278221 0.202818222763382 no 2729 0.187937853905458 3894 1948547
SGTC_720 r052-1644 49.9 µM -0.887776586477179 0.202223112665402 no 2730 0.187330469840224 3975 1422863 YOR257W CDC31
SGTC_2756 carbadox 75.1 µM -0.891010613766415 0.201371683848887 no 2731 0.186461738110532 3955 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1191 1487-1166 10.6 µM -0.892026176243641 0.201104758637185 no 2732 0.186189451061706 4003 3955771
SGTC_399 oxolinic acid 75 µM -0.892345691912858 0.201020822687586 no 2733 0.186103835256103 3921 4628 A DNA gyrase inhibitor.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.897203210293539 0.199747354980194 no 2734 0.184805246246429 3964 3256 An antibiotic and ribosome inhibitor.
SGTC_2935 9038016 29.96 µM -0.897211193401558 0.199745266097195 no 2735 0.184803116721543 3964 6463195
SGTC_224 benfluorex 43.875 µM -0.897572648366787 0.199650700520036 no 2736 0.184706713194143 3965 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2804 7954240 19.48 µM -0.899535689845839 0.199137590820317 no 2737 0.184183697242981 4021 828705
SGTC_1871 st057448 67.3 µM -0.899539092481205 0.199136702112536 no 2738 0.18418279147496 3992 691747
SGTC_2121 5257820 149.641 µM -0.899898018476752 0.199042970451269 no 2739 0.184087262371156 4023 791256
SGTC_3189 9110682 49.47 µM -0.901367237274883 0.198659568785079 no 2740 0.183696547527704 4057 17122418
SGTC_2620 irigenin 100 µM -0.901390297859485 0.198653554536157 no 2741 0.183690419061597 4030 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.901517647835912 0.198620343372262 no 2742 0.183656577460396 4026 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_121 0557-0495 61.343 µM -0.901733565482176 0.198564042601567 no 2743 0.183599209029547 4088 3104427
SGTC_2048 5246248 200 µM -0.902048740149889 0.198481877733223 no 2744 0.183515488466235 3962 677046
SGTC_1663 st014140 55.4 µM -0.902779884534426 0.198291350099982 no 2745 0.183321364564524 4047 4207120
SGTC_2951 9072950 58.06 µM -0.903091562187027 0.198210164135571 no 2746 0.18323865092677 3955 16488155
SGTC_2276 7947513 42.08 µM -0.903678448858462 0.198057346050904 no 2747 0.183082964956513 3934 2105100
SGTC_741 4582-0002 126 µM -0.904454577213975 0.197855361049686 no 2748 0.182877204791028 3939 2912688
SGTC_1125 tnp00248 1.32998 µM -0.905918044210636 0.197474837017768 no 2749 0.182489616420009 4082 24207736
SGTC_1662 st014054 52 µM -0.90938168207637 0.196576002336688 no 2750 0.181574343802352 4010 2838777
SGTC_1304 1165-0502 251 µM -0.914228943450432 0.195322278845827 no 2751 0.180298279320698 3994 767425
SGTC_168 3970-0862 530.542 µM -0.919388237100618 0.193993200186965 no 2752 0.178946269860264 3973 3135186
SGTC_1060 3448-7350 82 µM -0.91981331367254 0.193883943050438 no 2753 0.178835162383219 3960 570178
SGTC_106 0092-0003 11.579 µM -0.920536439725995 0.193698164650221 no 2754 0.178646249850828 3892 1072148
SGTC_2497 7-hydroxyflavone 100 µM -0.921050482273508 0.193566167943209 no 2755 0.178512035627429 4035 5281894
SGTC_1636 st007707 68.9 µM -0.921805330120155 0.193372436306347 no 2756 0.178315063354679 4036 403051
SGTC_129 0088-0017 176.636 µM -0.921950764323461 0.193335124227709 no 2757 0.178277129056308 3830 182446
SGTC_12 0849-0099 9.267 µM -0.922992439742636 0.193068004154602 no 2758 0.178005572559892 3885 6071388
SGTC_24 0417-1663 219 µM -0.92307828917622 0.193045999572378 no 2759 0.177983203934737 3999 4329390
SGTC_875 0709-0210 25.7 µM -0.923093765359844 0.193042032942029 no 2760 0.177979171703572 3999 6251364
SGTC_560 2332-1943 155 µM -0.923180765006419 0.193019735383927 no 2761 0.177956505515136 3963 21177716
SGTC_150 3970-0969 77.2 µM -0.925328093749227 0.192469884734515 no 2762 0.177397634772313 4094 6615640
SGTC_2607 solasodine 47.35 µM -0.926246328171346 0.1922350518047 no 2763 0.177158990700749 4005 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_21 0849-0113 22.993 µM -0.928241131379027 0.191725497165094 no 2764 0.176641251491707 3952 1560156
SGTC_2224 6650123 117.647 µM -0.929313398835543 0.191451938145831 no 2765 0.176363346677629 3970 2908370
SGTC_1167 k781-0610 148 µM -0.931143545902748 0.190985580166647 no 2766 0.175889657885302 4031 4525169
SGTC_3297 9117502 71.43 µM -0.932484072240528 0.190644429810261 no 2767 0.175543207169299 4020 7453720
SGTC_480 am 92016 50 µM -0.932774328307284 0.190570611878138 no 2768 0.175468249287789 3980 2129 K+ channel blocker.
SGTC_3140 9094243 49.47 µM -0.935034788514646 0.189996332194905 no 2769 0.174885185682382 4012 19291112
SGTC_58 0957-0393 9 µM -0.935282710462386 0.189933411349894 no 2770 0.174821311548243 3841 6997992
SGTC_894 0960-0238 55.9 µM -0.935476313598914 0.189884285145394 no 2771 0.174771442305909 4012 6741907 YDL195W SEC31
SGTC_585 0kpi-0023 191 µM -0.935595758809762 0.189853980185117 no 2772 0.174740679529258 3950 64601
SGTC_81 0411-0046 9.971 µM -0.936307245757454 0.189673527380338 no 2773 0.174557509301013 3946 12925265
SGTC_96 0929-0093 37.281 µM -0.936392606953005 0.189651884506177 no 2774 0.174535541506669 4001 6991579
SGTC_1091 telmisartan 47.6 µM -0.936407790011852 0.189648035082026 no 2775 0.174531634314278 4069 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.937739153614723 0.18931067582997 no 2776 0.174189238618546 4057 521171
SGTC_1208 2323-2347 50.3 µM -0.938169702333232 0.18920165656412 no 2777 0.174078602932452 4041 5412760
SGTC_2877 9040724 71.43 µM -0.938996706168336 0.188992359341404 no 2778 0.173866217738177 4009 6463895
SGTC_1085 doxorubicin 7.67 µM -0.93982627719084 0.188782555767323 no 2779 0.173653338890231 4034 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_225 nsc-122657 1.016 µM -0.941901010567066 0.188258471763855 no 2780 0.173121661349543 4024 275685
SGTC_1670 st016595 4.04 µM -0.944440385091345 0.187618241066548 no 2781 0.172472326173157 4020 597879
SGTC_90 0870-0863 4.608 µM -0.945017695628917 0.18747287661234 no 2782 0.172324920966779 4023 1738164
SGTC_1291 0993-0025 5.79 µM -0.947597126448114 0.186824237054376 no 2783 0.171667294809001 4028 4353356
SGTC_543 3844-1095 191 µM -0.948165245370146 0.186681561237703 no 2784 0.171522668554346 4035 4230703
SGTC_1932 st074806 40.9 µM -0.949064368786838 0.186455895767823 no 2785 0.171293937530566 4133 17251235
SGTC_1253 0550-0034 176 µM -0.949448258547923 0.186359597124358 no 2786 0.171196337957163 4064 5969915
SGTC_33 0986-0033 35.816 µM -0.9496679268385 0.186304507255069 no 2787 0.1711405058099 3946 2848082
SGTC_2222 6885208 172.143 µM -0.952029590055169 0.185712871244523 no 2788 0.170540987709554 3971 609514
SGTC_1574 spiramycin 23.7 µM -0.952236333601016 0.185661134081912 no 2789 0.170488569083126 3996 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2420 aureobasidin a 50 nM -0.952798072603132 0.185520605174123 no 2790 0.170346195525992 4167 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1775 st081588 35.1725 µM -0.95655240194218 0.184583089378745 no 2791 0.169396611564027 4042 1426443 YGL099W LSG1
SGTC_2979 9012552 45.46 µM -0.956553767070936 0.184582749021093 no 2792 0.169396266900522 4069 17100905
SGTC_2308 7584454 197.62 µM -0.956613869204755 0.184567764578811 no 2793 0.16938109294491 4105 893577
SGTC_670 4204-0025 119 µM -0.957829593405137 0.184264827136102 no 2794 0.16907434696806 4047 719039
SGTC_3167 9103034 49.47 µM -0.958300991446618 0.184147446193894 no 2795 0.168955502012451 4083 5127859
SGTC_1729 st035615 45.989 µM -0.960225508753485 0.183668712875927 no 2796 0.168470865607835 4079 17385451
SGTC_884 0851-0618 334 µM -0.960645474988239 0.183564347337615 no 2797 0.168365227665009 4066 9642473
SGTC_3226 9131256 49.47 µM -0.963330975498093 0.182897849448861 no 2798 0.167690726656507 3965 17178073
SGTC_1306 1185-0270 9.02 µM -0.965547189012867 0.182348960011876 no 2799 0.167135406128231 4081 1548076
SGTC_484 loperamide 105 µM -0.966392820608244 0.182139794067113 no 2800 0.166923827596495 4019 3955 An opioid-receptor agonist.
SGTC_2813 7971799 71.43 µM -0.96780627061445 0.181790513933043 no 2801 0.166570565768783 4101 2234054
SGTC_1609 st001574 46.4 µM -0.968861696794616 0.181529979133053 no 2802 0.166307099317969 4039 3960012
SGTC_2160 5660466 132.927 µM -0.971674864118184 0.180836683561682 no 2803 0.165606162698553 3936 2859134
SGTC_2976 9009005 19.48 µM -0.971909830148494 0.180778852175555 no 2804 0.165547704482968 4079 2993148
SGTC_528 3492-0019 172 µM -0.972147692270878 0.18072031979484 no 2805 0.165488539332239 4056 2869262
SGTC_3186 9110464 49.47 µM -0.974073107076344 0.180246957094326 no 2806 0.165010120656165 4067 17018021
SGTC_1058 3448-5425 97.3 µM -0.974145183643303 0.180229252213178 no 2807 0.164992228791219 3938 7279705
SGTC_2114 5491910 81.25 µM -0.974339016413103 0.180181644564476 no 2808 0.164944119111042 4122 2849228
SGTC_1514 1189-1591 158 µM -0.974673242102442 0.180099573275731 no 2809 0.164861184966803 4095 767698 YMR146C TIF34
SGTC_2015 5119600 184 µM -0.976534467581482 0.179642966617288 no 2810 0.16439983798657 4102 2828786
SGTC_667 1498-1044 59 µM -0.976745679205098 0.179591196951747 no 2811 0.164347537318929 4076 6739982
SGTC_1009 4106-0057 9.87 µM -0.976881173658053 0.179557991110109 no 2812 0.164313991577153 4053 2928005
SGTC_3001 9076041 71.4286 µM -0.977613226921849 0.179378652400162 no 2813 0.164132826490484 4047 16004211
SGTC_294 k038-0071 157 µM -0.977622246994111 0.179376443361751 no 2814 0.164130595053886 4056 24152826
SGTC_146 3448-8650 53.125 µM -0.977646451593275 0.179370515678997 no 2815 0.164124607280211 4054 2891488 YIL048W NEO1
SGTC_2961 9083290 32.55 µM -0.97975709917185 0.178854093830016 no 2816 0.163603016692684 4006 17741490
SGTC_1415 3966-0071 78.1 µM -0.979901477144568 0.178818802437941 no 2817 0.163567376877351 3995 2893185
SGTC_2885 9057732 51.95 µM -0.981798178770702 0.178355584527571 no 2818 0.16309964279284 4149 6471414
SGTC_3095 9117207 49.47 µM -0.981822385667113 0.178349677540332 no 2819 0.16309367890065 4053 17015229
SGTC_645 0845-0943 5.41 µM -0.985039804431852 0.177565657500737 no 2820 0.162302259704598 4072 1885106
SGTC_188 3229-0966 278.469 µM -0.985642497373045 0.177419035643561 no 2821 0.1621542880514 4111 5722370
SGTC_341 1486-1430 230 µM -0.986923867786173 0.177107560657112 no 2822 0.16183998123653 4047 2054753 YPL210C SRP72
SGTC_1243 0416-0003 5.65 µM -0.990195027259354 0.176313976287718 no 2823 0.16103940133178 4075 2141977
SGTC_1971 st069429 63.5 µM -0.990821845226572 0.176162167316955 no 2824 0.160886290176852 4054 1246522 YGL099W LSG1
SGTC_2241 6772625 37.8075 µM -0.99130665833787 0.17604480724541 no 2825 0.160767931367233 3942 2285411
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.991688192821695 0.175952482935766 no 2826 0.160674826251556 4027 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1492 4158-0558 28.5 µM -0.991792093569493 0.175927346183261 no 2827 0.160649477656508 4060 3967268
SGTC_1788 fluconazole 20 µM -0.992614813872888 0.175728385410299 no 2828 0.160448851368785 4127 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_464 bw-b 70c 158 µM -0.99455534222518 0.175259666863781 no 2829 0.159976288226417 4125 5353454
SGTC_1942 st076330 65.2 µM -0.995018195489802 0.175147985701131 no 2830 0.159863707426002 4145 24208414
SGTC_2167 5876490 200 µM -1.00240363507497 0.173372073930805 no 2831 0.158074343598495 4233 686534
SGTC_1420 4'-methoxyflavone 42 µM -1.00482044221566 0.172793423698145 no 2832 0.157491659321264 4078 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_454 lyso-paf C-16 6.67 µM -1.00596987321907 0.172518650679018 no 2833 0.157215031201826 4099 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2760 etidronate 98.04 µM -1.00685115614208 0.172308167645286 no 2834 0.157003153523727 4047 3305 A chelator and antioxidant.
SGTC_1746 st038117 42 µM -1.00693173823503 0.17228892983284 no 2835 0.156983789387122 4156 2898218
SGTC_1001 4048-4355 44.4 µM -1.01040014522295 0.171462196772507 no 2836 0.15615180916358 4066 21824233
SGTC_2821 7996764 71.43 µM -1.01065313271271 0.171401993785789 no 2837 0.156091237967811 4163 2987135
SGTC_215 1287-0124 461.5 µM -1.01082172825843 0.171361880904301 no 2838 0.156050880800149 4121 5560863
SGTC_2673 kobusone 100 µM -1.01217144155319 0.171040968422107 no 2839 0.15572804421317 4166 6710676 An epoxy ketone and protein crosslinker.
SGTC_2918 7977171 22.06 µM -1.01307676701129 0.170825930665116 no 2840 0.155511747274296 4071 2236483
SGTC_774 k060-0086 136 µM -1.01336848665179 0.170756676723001 no 2841 0.155442092960969 4089 5911235
SGTC_1610 st001799 48.1 µM -1.01586462442819 0.170164831035609 no 2842 0.154846928350285 4014 621897
SGTC_2483 5729050 27.16 µM -1.01624383167799 0.170075034412642 no 2843 0.1547566442599 4133 2865180
SGTC_323 4013-0906 34.3 µM -1.01737258948329 0.169807923315209 no 2844 0.15448810825008 4101 2910086
SGTC_1274 0865-0114 173 µM -1.01749971646682 0.169777856641441 no 2845 0.154457883541301 4101 870624
SGTC_2029 5175081 200 µM -1.01830413506106 0.169587683572944 no 2846 0.15426672195426 4077 1380876
SGTC_929 2805-0021 398 µM -1.01970660973989 0.169256450684284 no 2847 0.15393381298788 4180 3098024
SGTC_982 1491-0518 27.5 µM -1.02052560600659 0.169063214452013 no 2848 0.153739625804506 4025 3091256
SGTC_1051 3253-3903 78 µM -1.02055827590585 0.169055509165839 no 2849 0.153731883009902 4090 5509239
SGTC_1203 3992-3522 103 µM -1.02228118678141 0.168649475465072 no 2850 0.153323917413935 4248 5322312
SGTC_428 3448-4153 16.5 µM -1.02326002870751 0.168419073915452 no 2851 0.153092458639973 4077 3834874
SGTC_1527 coumarin 137 µM -1.02504924638762 0.167998448090649 no 2852 0.152669975785183 4209 323 A hepatotoxic, DNA x-linker.
SGTC_3257 9139206 32.98 µM -1.02623703265149 0.167719586053627 no 2853 0.15238993475853 4112 4910041
SGTC_2071 5230951 39.92 µM -1.02631393998357 0.167701540446861 no 2854 0.152371814292897 4152 1799272
SGTC_2299 7976368 114.88 µM -1.02743633927796 0.167438321940536 no 2855 0.152107523735644 4150 2979718
SGTC_481 bay k-8644 50 µM -1.03015200331896 0.166802562181208 no 2856 0.151469328310094 4082 2303 A calcium channel antagonist.
SGTC_1048 3161-0300 24.5 µM -1.03228098096621 0.166305241138028 no 2857 0.150970254042467 4105 2165101
SGTC_911 3456-4043 236 µM -1.03345780959065 0.16603074984432 no 2858 0.150694852449699 4147 914281
SGTC_1179 1021-1431 9.29 µM -1.03411519033599 0.165877545521463 no 2859 0.150541157840566 4150 2840958
SGTC_2331 7980721 200 µM -1.03432630705411 0.165828363602009 no 2860 0.150491821233843 4103 2981221
SGTC_2061 5245884 80.95 µM -1.0355170001988 0.165551155299274 no 2861 0.150213765674497 4091 573863
SGTC_26 0302-0163 425.158 µM -1.03555312924096 0.165542748692732 no 2862 0.150205334028011 4185 3100915
SGTC_72 0744-0168 198.391 µM -1.03663788906942 0.165290472342983 no 2863 0.149952324182366 4023 677577
SGTC_943 3253-1379 105 µM -1.03696614998379 0.165214179651027 no 2864 0.149875816510925 4163 668464
SGTC_189 3970-0742 2.116 µM -1.03711571391155 0.165179426340919 no 2865 0.149840966326418 4047 2891807
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.03719158664082 0.165161798040163 no 2866 0.149823289139363 4186 5393153
SGTC_1329 1447-1697 50.6 µM -1.03725574184824 0.165146893143407 no 2867 0.149808343041318 4135 2840515
SGTC_1312 1218-2183 165 µM -1.03761844899548 0.165062643365997 no 2868 0.149723862658156 4170 6744073
SGTC_1803 st050068 52.4 µM -1.03840807332786 0.164879325321271 no 2869 0.149540056262277 4180 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_512 prima-1 270 µM -1.03959216671344 0.164604675124887 no 2870 0.149264708873595 4136 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1981 st071826 47 µM -1.04109159101629 0.164257309644714 no 2871 0.148916520938505 4156 11838600
SGTC_1437 4092-1038 11.6 µM -1.04357945333688 0.163682006233734 no 2872 0.148340001571277 4167 3977136
SGTC_1784 st039334 36.3 µM -1.04500223565862 0.163353584935514 no 2873 0.148010968125168 4201 3496984
SGTC_2512 diallyl trisulfide 49.23 µM -1.05086760153688 0.162004203943517 no 2874 0.146659701120627 4167 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_791 1348-1292 225 µM -1.05124391834792 0.161917877384665 no 2875 0.146573288500334 4121 5437054
SGTC_1769 st044406 64.4 µM -1.05160686968409 0.161834645243176 no 2876 0.146489977337075 4111 670903
SGTC_2375 9072683 200 µM -1.05440128266956 0.161194763122652 no 2877 0.145849617636628 4227 16798029
SGTC_890 0929-0006 47.2 µM -1.05593974373614 0.160843182202661 no 2878 0.145497872468102 4117 1378169
SGTC_2324 6149169 200 µM -1.05622204241516 0.160778723544623 no 2879 0.145433391268859 4053 2888231
SGTC_3286 9117135 37.221 µM -1.05681092260942 0.160644315906076 no 2880 0.14529894418579 4124 3438150
SGTC_913 3487-1245 167 µM -1.05740133300609 0.160509632703174 no 2881 0.145164231714008 4082 4016153
SGTC_595 3909-8003 73.7 µM -1.05906150628662 0.160131312860347 no 2882 0.144785884672536 4223 699517
SGTC_852 0418-0143 439 µM -1.05943708605696 0.160045806769364 no 2883 0.144700383694227 4162 5369229
SGTC_2314 7727897 200 µM -1.06104062090305 0.159681075100067 no 2884 0.144335720556521 4164 900724
SGTC_1661 st013063 9.66 µM -1.06132059378137 0.159617449745646 no 2885 0.144272114921852 4204 721395
SGTC_2245 6637752 200 µM -1.06305194635795 0.159224359077264 no 2886 0.143879197343789 4219 681890
SGTC_1814 st052110 31.539 µM -1.06385655388698 0.159041894924666 no 2887 0.143696843569292 4111 674163
SGTC_2077 5212015 200 µM -1.06425369572796 0.158951883956289 no 2888 0.143606894077339 4011 780900
SGTC_3127 9126946 49.47 µM -1.06465747432876 0.158860403017422 no 2889 0.143515480379755 4152 27243249
SGTC_869 0564-0080 44.1 µM -1.06531857472096 0.158710697222031 no 2890 0.143365894985223 4159 6843321
SGTC_1603 st002045 67.8 µM -1.06677576769366 0.15838104345669 no 2891 0.143036551762909 4164 5887985
SGTC_1862 st057513 3.81 µM -1.07370664908194 0.156819257042469 no 2892 0.141477090175589 4154 5393163
SGTC_1200 1643-0193 18.4 µM -1.07444104258743 0.15665436659103 no 2893 0.141312527886917 4199 5403974
SGTC_2036 5160441 105 µM -1.07565507900938 0.156382034185751 no 2894 0.141040772246247 4141 134534 YIL048W NEO1
SGTC_976 1348-1067 47.6 µM -1.07924843099181 0.155577802487193 no 2895 0.140238497474877 4179 5310671 YGL099W LSG1
SGTC_1783 st039459 87.517 µM -1.08091946322207 0.155204738093701 no 2896 0.139866470026989 4280 729761
SGTC_661 1304-0007 33.6 µM -1.0812068087008 0.155140646659146 no 2897 0.139802565003967 4179 3117130
SGTC_524 r073-0010 27.8 µM -1.08180469082546 0.155007347087976 no 2898 0.139669660913401 4108 2772106
SGTC_198 3454-2873 16.191 µM -1.08207320466703 0.154947505759196 no 2899 0.139610000542974 4160 710957
SGTC_1988 st071872 53.4 µM -1.08292164000264 0.154758522688142 no 2900 0.13942160287033 4206 16414116
SGTC_2587 piperic acid 92.2 µM -1.08327385738438 0.154680113466224 no 2901 0.13934344274214 4171 5370536
SGTC_778 3456-2434 196 µM -1.08558606880921 0.154166030133589 no 2902 0.138831082996812 4137 5539063
SGTC_816 0325-0417 81.3 µM -1.08601580018172 0.154070610896334 no 2903 0.138736000972595 4200 68101
SGTC_1447 4239-0816 81.9 µM -1.09109060065192 0.152946737871096 no 2904 0.13761650916611 4187 1341554
SGTC_2049 5262831 67.185 µM -1.09132836915184 0.152894214934129 no 2905 0.137564209504119 4181 763417
SGTC_43 0570-0105 72.5 µM -1.09152430678242 0.152850941403975 no 2906 0.137521121176533 4167 1114046 YDL195W SEC31
SGTC_3264 9137442 49.47 µM -1.09496318938363 0.152092774046784 no 2907 0.13676638180304 4185 17015726
SGTC_1456 k015-0012 13 µM -1.09731715753259 0.151575239108746 no 2908 0.136251386577147 4216 2989616
SGTC_572 0960-0087 17.7 µM -1.09867327491497 0.151277620135408 no 2909 0.135955301817037 4171 6796365
SGTC_860 0443-0016 25.1 µM -1.09882011347316 0.151245417693157 no 2910 0.135923268610864 4210 5337942
SGTC_180 1486-1293 102.781 µM -1.10079820494328 0.150812056647633 no 2911 0.135492246598108 4098 4140536
SGTC_2939 9044578 71.43 µM -1.10286614277957 0.150359896694719 no 2912 0.135042649605009 4125 2653634
SGTC_1439 4092-1168 46 µM -1.10678473911259 0.149505565454434 no 2913 0.134193503917256 4193 2886240
SGTC_462 ag-879 158 µM -1.10743998803666 0.149363025058635 no 2914 0.134051872535648 4234 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_414 piperonyl butoxide 100 µM -1.11310159577086 0.148135199424432 no 2915 0.132832399209367 4196 5794 A potent inhibitor of cytochrome P450.
SGTC_2661 dactinomycin 12.96 µM -1.11420514882285 0.147896662070381 no 2916 0.132595593535615 4172 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3282 9108498 15.4605 µM -1.11587952060004 0.147535231309615 no 2917 0.132236854534881 4178 16459645
SGTC_854 0422-0053 192 µM -1.11800516452415 0.14707724181866 no 2918 0.131782393820141 4219 3596728
SGTC_442 cape 100 µM -1.12119307108978 0.146392166761412 no 2919 0.131102844228704 4219 5281787
SGTC_1265 0819-1001 68.8 µM -1.12126824545866 0.146376037830499 no 2920 0.131086848964264 4168 3106768
SGTC_2742 clothiapine 36.27 µM -1.12131008100459 0.146367062380588 no 2921 0.131077947968695 4215 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1402 3909-7673 35.9 µM -1.12252932582988 0.146105646391007 no 2922 0.130818722939576 4212 5328014
SGTC_2437 5741531 144.16 µM -1.12428688602911 0.145729363448621 no 2923 0.130445669943513 4241 2262990
SGTC_616 4092-0450 108 µM -1.12476542558146 0.145627023976172 no 2924 0.130344224535848 4208 787165
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.12521200680517 0.14553156264404 no 2925 0.130249603202756 4276 23847180
SGTC_830 4076-0286 57.8 µM -1.1253855622311 0.145494474743301 no 2926 0.130212843221187 4289 6866659
SGTC_2470 5664817 21.68 µM -1.12681547955932 0.145189150710177 no 2927 0.129910252176244 4255 2859561
SGTC_1035 k081-0041 55.2 µM -1.12714453273824 0.145118950484279 no 2928 0.129840688754701 4244 731709
SGTC_1220 1838-0075 193 µM -1.12787670604284 0.144962830560815 no 2929 0.129685996356826 4118 5529645
SGTC_946 3434-1334 87.4 µM -1.12849739158347 0.144830571546541 no 2930 0.129554958922511 4206 4047976
SGTC_580 1123-0028 41 µM -1.13004158914087 0.144501878260716 no 2931 0.129229350214821 4260 1677248 YPR107C YTH1
SGTC_2762 leflunomide 42.06 µM -1.13015856805216 0.144476998975053 no 2932 0.129204707235475 4197 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3273 9137859 49.47 µM -1.1354052006152 0.143364103147895 no 2933 0.12810279083401 4324 2377234
SGTC_1341 1486-1360 280 µM -1.13623234635767 0.14318918176812 no 2934 0.127929668194581 4215 3976547
SGTC_2944 9067346 25.62 µM -1.13626533168434 0.143182209157258 no 2935 0.127922767696664 4177 6473075
SGTC_2080 5212524 12.4 µM -1.13695182697064 0.143037146248979 no 2936 0.12777921225694 4161 260183
SGTC_799 1310-0557 151 µM -1.13927032025747 0.142547961006442 no 2937 0.127295211760053 4289 5354492
SGTC_2750 bromebric acid 70.15 µM -1.14306974755694 0.141748758268804 no 2938 0.126504816816448 4274 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1830 st055982 50.3 µM -1.14435411857292 0.141479280789007 no 2939 0.126238403908481 4199 455313 An antimicrobial agent.
SGTC_14 0354-0009 295 µM -1.1451078042016 0.141321309628156 no 2940 0.126082251527738 4322 1713507
SGTC_635 k038-0028 24.7 µM -1.1461443296295 0.141104251100745 no 2941 0.125867718993372 4235 4035102
SGTC_2638 epoxomicin 18 µM -1.15000984594595 0.140296768659445 no 2942 0.125069908011259 4215 9915668 A protesome inhibitor.
SGTC_793 0488-0545 106 µM -1.15016544538466 0.140264330736467 no 2943 0.125037867673137 4273 292548
SGTC_1059 3448-6867 171 µM -1.15127984411844 0.140032160145126 no 2944 0.124808563252796 4197 3934407
SGTC_3007 9078383 71.4286 µM -1.15320311684445 0.139632085603685 no 2945 0.124413512256405 4229 6496995
SGTC_1123 mangostin 811.285 nM -1.15364078278602 0.139541152059993 no 2946 0.124323735482337 4244 5281650 An antioxidant.
SGTC_855 0428-0020 25 µM -1.15412205822289 0.139441204306372 no 2947 0.124225065571647 4264 6812414
SGTC_2681 menadione 3.18 µM -1.15500232640811 0.139258522678195 no 2948 0.124044736895111 4258 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1764 st044502 93.5 µM -1.15607533884952 0.139036061265443 no 2949 0.123825171125026 4287 8407
SGTC_1696 st025591 34.7925 µM -1.15828163197508 0.138579403828822 no 2950 0.123374562315032 4254 2787147
SGTC_1316 1272-0050 65.9 µM -1.1625163596051 0.137705767792109 no 2951 0.122512891681497 4206 7340392
SGTC_1590 st077108 57.8 µM -1.16462463144969 0.137272229844856 no 2952 0.122085484458249 4273 5489485
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.17093453783124 0.135980256290011 no 2953 0.120812545546316 4273 5106787 A p450 inhibitor.
SGTC_163 TUB2.036 7.546 µM -1.17158204379734 0.135848149894915 no 2954 0.120682450346468 4231 15992207 YJR013W GPI14
SGTC_3336 9143619 71.43 µM -1.17446768214958 0.135260480809794 no 2955 0.120103874669991 4297 45595730
SGTC_1082 camptothecin 424.86 nM -1.17462985423286 0.135227505771332 no 2956 0.120071416990323 4147 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2251 lansoprazole 556 µM -1.17607255167003 0.134934399461215 no 2957 0.119782942651452 4198 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_460 trequinsin 123 µM -1.17675856297381 0.134795178637068 no 2958 0.119645942942967 4342 5537 A vasodilator.
SGTC_939 1165-0479 45.3 µM -1.17995680607787 0.134147420329778 no 2959 0.119008697352198 4267 1377347
SGTC_1695 st026914 34.495 µM -1.17999976581476 0.134138734029748 no 2960 0.119000154026015 4250 3289191
SGTC_2764 methyldopa 94.69 µM -1.18150781628992 0.133834056624885 no 2961 0.118700525108857 4275 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2429 5902844 64.44 µM -1.18693489346732 0.132741540558554 no 2962 0.117626651219311 4274 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_114 0364-0001 490.298 µM -1.18838242628612 0.132451180655276 no 2963 0.117341388425665 4305 4003655
SGTC_1242 0402-0103 60.1 µM -1.19500047441116 0.131129246131502 no 2964 0.116043422380752 4215 432868
SGTC_807 1315-0151 48 µM -1.19534108968592 0.131061456766751 no 2965 0.115976896005884 4317 4011080
SGTC_2779 methotrexate 400 µM -1.1960490444611 0.130920636839129 no 2966 0.115838710318168 4294 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1959 st077091 55.8 µM -1.20298412691823 0.129546701369539 no 2967 0.114491231545931 4290 821356 YKL052C ASK1
SGTC_1251 0490-5699 265 µM -1.20428821774012 0.129289462848527 no 2968 0.114239099518252 4329 3883818
SGTC_2693 st077581 40.7 µM -1.20472303179769 0.129203772325848 no 2969 0.114155120829937 4305 25238761
SGTC_712 r015-0009 80.6 µM -1.20750729889703 0.12865599902855 no 2970 0.113618417933812 4323 6813872 YLR060W FRS1
SGTC_711 k292-0785 179 µM -1.20979653227281 0.128206826844895 no 2971 0.11317848859914 4211 4146315
SGTC_2348 9022543 33.42 µM -1.21035645774059 0.128097129413655 no 2972 0.113071071154832 4317 3162678 YDL140C RPO21
SGTC_1616 st002734 56.1 µM -1.21267996901732 0.127642616910012 no 2973 0.112626100567901 4231 4026101
SGTC_423 5-fluorouracil 457 µM -1.21443102455348 0.12730082670659 no 2974 0.112291587112589 4229 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_735 3076-0345 636 µM -1.21500399753735 0.127189125929484 no 2975 0.112182283360329 4354 2888990
SGTC_2854 9024559 71.43 µM -1.21588945789869 0.127016640057785 no 2976 0.112013517248872 4315 3163529
SGTC_1078 idebenone 36.1 µM -1.21810961924546 0.126584873210832 no 2977 0.111591159467452 4347 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2040 5100729 123 µM -1.21943694277861 0.126327230208608 no 2978 0.111339197750343 4321 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_435 c-PAF 6.7 µM -1.22068331953869 0.126085632433279 no 2979 0.111102972886116 4263 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1669 st015249 58.4 µM -1.23025858134927 0.124240304541978 no 2980 0.109300144537765 4400 722793
SGTC_2026 5148700 152 µM -1.23089754131347 0.124117841168276 no 2981 0.109180593653365 4282 79838
SGTC_2110 5483698 200 µM -1.23105314913134 0.124088030091701 no 2982 0.109151493304258 4290 2848765 YHR062C RPP1
SGTC_1992 st073643 23.3 µM -1.23151790934452 0.123999021962005 no 2983 0.109064611289489 4289 3161292
SGTC_2183 6420625 130.508 µM -1.23425323374965 0.123476074077759 no 2984 0.108554278249109 4326 2897619
SGTC_371 0195-0006 7.36 µM -1.23706345174643 0.122940418668715 no 2985 0.108031763501567 4147 3928593
SGTC_2870 9038528 12.99 µM -1.23884789438066 0.12260113312374 no 2986 0.107700916575653 4350 6463316
SGTC_3070 9117005 49.47 µM -1.23942246658219 0.122492026604659 no 2987 0.107594542782356 4404 8779016
SGTC_2109 5483026 200 µM -1.23951446002635 0.122474564138382 no 2988 0.107577518550259 4331 759335
SGTC_2266 7929956 200 µM -1.2424988092273 0.121909013532697 no 2989 0.107026289780806 4266 2967153
SGTC_1501 4491-0275 38.4 µM -1.24866929186967 0.120745496900999 no 2990 0.10589302847515 4309 5104718
SGTC_2881 9058953 51.95 µM -1.24936657959739 0.120614508378924 no 2991 0.105765513130111 4270 17122249
SGTC_2732 terfenadine 20 µM -1.25085435433385 0.120335357998827 no 2992 0.105493809943158 4397 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_604 1000-0114 314 µM -1.25162243928339 0.1201914208909 no 2993 0.105353737035466 4335 1572745
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.2531395313292 0.119907478350795 no 2994 0.105077465803175 4349 16486 A toxic proline analog.
SGTC_1671 st016596 74.5 µM -1.25512441538522 0.119536697300243 no 2995 0.104716799256199 4381 2829167
SGTC_1680 diphenhydramine 100 µM -1.25788319233512 0.119022695649013 no 2996 0.104217001528389 4305 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1366 1683-0113 21.9 µM -1.25928019415317 0.118763009242131 no 2997 0.103964572221789 4320 708623
SGTC_345 1362-0200 395 µM -1.26113213658176 0.118419372011875 no 2998 0.103630621951722 4328 1419823
SGTC_3348 9149464 3.537 µM -1.26132376990607 0.118383853651723 no 2999 0.103596110290631 4269 1951442
SGTC_159 3970-0959 50 µM -1.26228341731119 0.118206100676625 no 3000 0.10342341076027 4391 6615653
SGTC_949 1165-0505 146 µM -1.26390235054125 0.117906657823596 no 3001 0.103132539016646 4312 6244267
SGTC_1350 1495-0454 146 µM -1.26541884805091 0.117626648977255 no 3002 0.102860611106895 4373 1069057
SGTC_1919 st067113 52.3 µM -1.26633533391193 0.117457655732928 no 3003 0.102696525920343 4347 1268243
SGTC_2463 5473429 200 µM -1.27358642489154 0.11612666700626 no 3004 0.101405012881781 4327 5399405
SGTC_2200 6600604 21.907 µM -1.27439679124169 0.115978586257249 no 3005 0.101261414468829 4377 2904777
SGTC_1709 st033179 39.1045 µM -1.27475417105884 0.115913323752354 no 3006 0.101198133206514 4341 573381
SGTC_2731 amoxapine 43.43 µM -1.27684762984461 0.115531552896742 no 3007 0.100828023113109 4500 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1007 4101-0031 70 µM -1.27823215511656 0.115279557080701 no 3008 0.100583790763479 4339 1146276
SGTC_965 1291-5240 308 µM -1.27860989072278 0.115210873756142 no 3009 0.100517232626163 4349 2834598
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.27961295479515 0.115028628729683 no 3010 0.100340645719503 4367 66535 A nucleotide analog.
SGTC_2541 muurolladie-3-one 83.07 µM -1.28134922506713 0.114713653442503 no 3011 0.100035515020533 4303 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3325 9138760 55.175 µM -1.28146167203266 0.114693275715745 no 3012 0.100015777070142 4293 43844959
SGTC_2689 tacrolimus 100 µM -1.28227099415474 0.114546685712896 no 3013 0.0998737996761984 4356 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.28286520674463 0.114439142761853 no 3014 0.0997696521764765 4347 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1836 st055642 81 µM -1.28717332196526 0.113661592290388 no 3015 0.0990169418213796 4344 8571
SGTC_1967 st070177 51.4 µM -1.28763905732655 0.11357776013419 no 3016 0.0989358184010516 4379 5729214
SGTC_272 doxorubicin 8.13 µM -1.28818069582242 0.113480320905764 no 3017 0.0988415350758498 4379 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1486 3970-0793 4.53 µM -1.29156491124688 0.11287285982886 no 3018 0.0982539310842637 4391 2844330
SGTC_525 k781-2675 26.7 µM -1.29365442962937 0.112498955790567 no 3019 0.0978924063038245 4313 3651118 YDL195W SEC31
SGTC_1491 4138-0063 26.5 µM -1.2961961673637 0.112045324211039 no 3020 0.0974539548227875 4351 23883227
SGTC_2010 4012422 159 µM -1.2967582688465 0.111945181093367 no 3021 0.0973571867323994 4312 952393
SGTC_3323 9138564 53.9225 µM -1.29771417138423 0.111775025992123 no 3022 0.0971927860641685 4367 43912313 YNL103W MET4
SGTC_591 4299-0174 154 µM -1.29834116722575 0.111663518325448 no 3023 0.0970850630260776 4397 5509088
SGTC_2168 5727979 200 µM -1.30187070409413 0.111037294958689 no 3024 0.096480294341314 4284 695210
SGTC_2386 9075165 157.42 µM -1.30477371232138 0.110524120906103 no 3025 0.0959849564586299 4357 16452277
SGTC_573 3702-0553 84.7 µM -1.30491920950051 0.11049844571928 no 3026 0.0959601797009564 4311 1222756
SGTC_671 0560-0003 407 µM -1.30520418974445 0.110448169017242 no 3027 0.0959116639596832 4291 3238678
SGTC_3144 9087057 49.47 µM -1.30686935626861 0.110154725366311 no 3028 0.0956285425163352 4290 17249618
SGTC_1105 epirubicin 18.1 µM -1.30786188179639 0.109980083981953 no 3029 0.0954600802480039 4392 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2699 st077704 54.6 µM -1.30817980195232 0.109924185875998 no 3030 0.0954061655852217 4370 645852
SGTC_2533 agelasine 13.65 µM -1.31276549348336 0.109120176600717 no 3031 0.0946309904280418 4435 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3006 9075424 71.4286 µM -1.31360145834456 0.108974063471541 no 3032 0.0944901788532989 4339 7465181
SGTC_377 3970-0964 33.1 µM -1.31518198200943 0.108698197920094 no 3033 0.0942243745728766 4351 16481235
SGTC_3218 9131285 49.47 µM -1.31558923259701 0.108627197604209 no 3034 0.0941559747309119 4366 17156417
SGTC_863 0466-0191 129 µM -1.31714128395258 0.108356917832455 no 3035 0.0938956354820351 4432 765160 YPR165W RHO1
SGTC_1776 st049249 45.9 µM -1.32367637099495 0.107224183222051 no 3036 0.0928052746060205 4405 1822314
SGTC_1633 st005664 67.9 µM -1.32631883106244 0.106768594931661 no 3037 0.0923670559627999 4366 2063822
SGTC_3170 9103054 49.47 µM -1.32818832981834 0.106447118229159 no 3038 0.0920579493714453 4364 16432970
SGTC_2067 5224629 34.075 µM -1.33177520057987 0.105832282326982 no 3039 0.0914670347288101 4376 2835000
SGTC_257 daunorubicin 18.5 µM -1.33205913151766 0.105783722766833 no 3040 0.0914203792282041 4415 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1223 0764-0573 147 µM -1.3324418614388 0.105718291506749 no 3041 0.0913575170078759 4388 1609797
SGTC_3096 9117468 49.47 µM -1.3326601153343 0.105680992064282 no 3042 0.0913216838220149 4326 41316311
SGTC_1903 st060211 78.3 µM -1.3339275873305 0.105464570019869 no 3043 0.0911137946910591 4410 688960
SGTC_2101 5377231 179.231 µM -1.33597466165118 0.105115707403903 no 3044 0.0907787777023547 4422 2844213
SGTC_2359 9039622 200 µM -1.34060598450405 0.10432952070534 no 3045 0.0900242066094532 4351 6463596
SGTC_2823 7987624 58.44 µM -1.34224868561317 0.104051691584686 no 3046 0.089757687727477 4369 2239440
SGTC_245 methotrexate 289.6 µM -1.34398582697044 0.103758473854662 no 3047 0.0894764850366842 4353 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1313 1220-0047 237 µM -1.34687453551351 0.103272207346236 no 3048 0.0890103220300934 4385 3528706
SGTC_2692 st077426 47.7 µM -1.34788062122567 0.10310323848501 no 3049 0.0888483909392086 4396 25238571
SGTC_370 0180-0345 38.7 µM -1.35650294385009 0.101663375519107 no 3050 0.0874695996762238 4249 3989527
SGTC_864 0469-0573 172 µM -1.3566061455895 0.101646230727349 no 3051 0.0874531940053769 4384 689425
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.35698628873866 0.101583096122905 no 3052 0.0873927835993989 4346 97141
SGTC_3250 9135583 49.47 µM -1.35849705556457 0.101332468516707 no 3053 0.0871530081265913 4421 7699353
SGTC_2724 maprotiline 69.64 µM -1.36084873902939 0.10094323452263 no 3054 0.0867807478837459 4347 4011 A tricyclic antidepressant.
SGTC_2112 5488546 200 µM -1.36219853154859 0.100720319361908 no 3055 0.0865676195698436 4378 600757
SGTC_1545 lovastatin 49.4 µM -1.36436295993235 0.100363618718798 no 3056 0.0862266797371076 4440 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2630 antimycin a 100 µM -1.36629313885107 0.100046301095401 no 3057 0.0859234868356817 4347 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.36762409713975 0.0998279212964797 no 3058 0.0857148848464103 4434 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3190 9110366 49.47 µM -1.37133744873936 0.0992204865505344 no 3059 0.0851348934208161 4427 17123768
SGTC_1063 disulfiram 1.84 µM -1.37211756613402 0.0990932182281597 no 3060 0.0850134209418985 4431 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1339 1486-1321 22.7 µM -1.3751958477824 0.0985921925327378 no 3061 0.0845353676304 4444 3469382
SGTC_3083 9117465 49.47 µM -1.3888284829344 0.0963956083429152 no 3062 0.0824424559138274 4390 16420915
SGTC_1744 st037937 38.9 µM -1.38911791554494 0.0963493660211174 no 3063 0.0823984483868465 4463 1016152
SGTC_1583 clindamycin 39.6 µM -1.38930550826416 0.0963194032525139 no 3064 0.0823699348171516 4383 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1889 st059080 5.18 µM -1.39216030716058 0.0958642725529019 no 3065 0.0819369297396609 4407 176925 Isolated from Daphnopsis sellowiana.
SGTC_2468 5987765 72.9 µM -1.39288925427731 0.0957483129654657 no 3066 0.0818266411974664 4483 26772094
SGTC_2549 cedrol 20.94 µM -1.39296576731352 0.0957361473969007 no 3067 0.0818150713879661 4365 6708665 A sedative which affects the nervous system.
SGTC_697 0508-1955 564 µM -1.39405971452653 0.0955623341930115 no 3068 0.0816497865353911 4439 6243113
SGTC_2919 7978188 46.38 µM -1.39442746824064 0.0955039553612588 no 3069 0.0815942790804482 4446 2980291
SGTC_1335 1486-0900 202 µM -1.39606406405613 0.0952444732937315 no 3070 0.0813476020678208 4424 X1335
SGTC_2734 clemastine 41.6 µM -1.39774129774691 0.0949790870854591 no 3071 0.0810953839825594 4505 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2316 5844804 197.44 µM -1.40012893349321 0.0946022352721876 no 3072 0.0807373560908775 4441 776813
SGTC_752 1896-0090 130 µM -1.40331785812601 0.0941006329525907 no 3073 0.0802610376282447 4424 772567
SGTC_407 eburnamonine 100 µM -1.40417363856631 0.0939663574061109 no 3074 0.0801335748633788 4288 3195
SGTC_1951 sophoraflavanone G 9.2 µM -1.40509213863238 0.0938223982635042 no 3075 0.0799969407426426 4390 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_13 0199-0087 65 µM -1.40621288638074 0.0936469608593258 no 3076 0.079830459374702 4549 4589825
SGTC_2593 nobiletin 86.24 µM -1.41179130727988 0.0927773392409318 no 3077 0.0790057093729485 4419 72344 An anti-infammatory.
SGTC_1765 st044815 90.4 µM -1.41855518119524 0.091730944887889 no 3078 0.0780143701376368 4465 645695
SGTC_2156 5649887 115 µM -1.41941452114862 0.0915986305454575 no 3079 0.0778891006782127 4472 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2014 4013930 200 µM -1.41981556800027 0.0915369289595778 no 3080 0.0778306907257774 4422 64556
SGTC_2925 9010536 32.5 µM -1.42004744705317 0.0915012681180088 no 3081 0.0777969341701907 4366 2994177
SGTC_176 1486-1328 72.834 µM -1.42107840042385 0.0913428417300929 no 3082 0.0776469842673205 4476 22310231
SGTC_2555 cholic acid 100 µM -1.42182368079254 0.0912284413515798 no 3083 0.0775387215932633 4402 6708657 Influences liver metabolism.
SGTC_1156 4092-0367 4.88 µM -1.42734418025591 0.0903843520647244 no 3084 0.076740355940391 4496 1357585
SGTC_3291 9121177 71.43 µM -1.43056039094545 0.0898952716927751 no 3085 0.0762781231036931 4444 17015612
SGTC_1384 3089-0840 101 µM -1.43057731043958 0.0898927040026529 no 3086 0.0762756970539746 4458 1069836
SGTC_3332 9141069 11.198 µM -1.4315778891556 0.0897409538135245 no 3087 0.076132330625486 4385 17332883
SGTC_2212 7123476 200 µM -1.43216088193174 0.0896526235702948 no 3088 0.0760488920024194 4473 1085715
SGTC_2736 butenafine 14.65 µM -1.43289363074085 0.089541695235652 no 3089 0.0759441188798858 4399 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1978 st071761 42 µM -1.43291845492082 0.0895379389763518 no 3090 0.0759405712853444 4463 5147680
SGTC_1899 st063254 59.6 µM -1.43514271899859 0.0892018509367506 no 3091 0.0756232162251657 4421 3093813
SGTC_2812 7970281 58.44 µM -1.43602317390969 0.0890690731607493 no 3092 0.0754978735959415 4482 2233435
SGTC_148 3253-0744 288.01 µM -1.43964560936911 0.0885243359878724 no 3093 0.0749838444135413 4336 6893655
SGTC_1103 duloxetine 36.1 µM -1.44000137835471 0.0884709700481778 no 3094 0.0749335045525107 4513 60835 A selective serotonin reuptake inhibitor.
SGTC_786 4544-0069 423 µM -1.4407734133684 0.0883552459611675 no 3095 0.0748243534185545 4445 748821 YLR208W SEC13
SGTC_2270 7924575 90.91 µM -1.44253143410493 0.0880921486254205 no 3096 0.074576255221433 4429 1262135
SGTC_2195 6536160 144.242 µM -1.44536134697051 0.0876698643267405 no 3097 0.074178207285498 4460 3834386
SGTC_3076 9116187 49.47 µM -1.44884952821871 0.0871514325184644 no 3098 0.0736898043782746 4461 27241210
SGTC_2978 9011784 42.97 µM -1.45303006513539 0.0865331193575428 no 3099 0.0731077033090766 4448 2994934
SGTC_1733 st037357 54.9 µM -1.45377801218394 0.0864228425841276 no 3100 0.0730039307027503 4384 1272339 YGL099W LSG1
SGTC_1851 st056236 18.9 µM -1.45529937986169 0.0861988575308369 no 3101 0.0727931991287308 4455 5393171
SGTC_513 4245-1575 41.7 µM -1.45725062546976 0.0859122191736998 no 3102 0.072523605317367 4302 719745
SGTC_1734 st037168 69.4 µM -1.45802090948077 0.0857992608918314 no 3103 0.072417389846852 4469 708907
SGTC_1273 0849-0096 14.1 µM -1.46049419182619 0.0854373179815467 no 3104 0.0720771513315298 4498 5286025
SGTC_1122 capsaicin 818.572 nM -1.46125023370852 0.0853269065035951 no 3105 0.0719733909250664 4515 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_385 1494-0393 12.4 µM -1.46896467637318 0.084206401552089 no 3106 0.0709211852275491 4448 3090647
SGTC_3246 9135460 32.98 µM -1.47007492793265 0.0840460534254853 no 3107 0.0707707309550706 4448 41446951
SGTC_1040 k898-0338 155 µM -1.47099811487081 0.0839128967675174 no 3108 0.0706458133419587 4465 20969351
SGTC_1066 ketoconazole 628 nM -1.47185073384147 0.0837900593238932 no 3109 0.0705305949557264 4541 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2706 st078239 82.5 µM -1.47221223468933 0.0837380184228824 no 3110 0.070481787283668 4471 15434492
SGTC_149 3970-0822 46.1 µM -1.47423308555191 0.0834475481477436 no 3111 0.0702094222822779 4450 3114250 YBL034C STU1
SGTC_2083 5306046 65.942 µM -1.476578657929 0.0831113538345632 no 3112 0.0698943080458118 4468 539837
SGTC_2718 lomofungin 53.02 µM -1.47697480071408 0.0830546747925753 no 3113 0.0698411961231632 4456 5351222 A RNA synthesis inhibitor.
SGTC_1302 1159-0335 255 µM -1.47768603418377 0.0829529863829537 no 3114 0.0697459171017344 4495 649284
SGTC_1743 st037606 46.3785 µM -1.48296846959714 0.0822006606302764 no 3115 0.0690413940943834 4441 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1965 Pectolinarigenin 58.4 µM -1.48526146215202 0.0818756962428897 no 3116 0.0687372881474783 4466 5320438 An anti-inflammatory.
SGTC_3131 9127911 49.47 µM -1.48529345257994 0.081871169396658 no 3117 0.0687330527650118 4480 45595681
SGTC_1800 st050079 29.0735 µM -1.49345981695274 0.0807217371135564 no 3118 0.0676584325782893 4306 3645560
SGTC_2953 9074162 66.49 µM -1.4971365334725 0.08020822777988 no 3119 0.0671788676807552 4469 16451992
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.49718513446543 0.0802014564855635 no 3120 0.0671725461578395 4452 2724 A muscle relaxant with antifungal properties.
SGTC_285 1486-1325 46 µM -1.49780779003745 0.0801147437205022 no 3121 0.0670915981417762 4530 22310230
SGTC_1728 st035614 33.7865 µM -1.50242809017989 0.0794735204901528 no 3122 0.0664932931703085 4448 15945546
SGTC_717 1532-0246 73.2 µM -1.50521033275212 0.0790892680866354 no 3123 0.0661350047428104 4478 9561992
SGTC_2815 7968870 71.43 µM -1.50775747610546 0.0787387201171317 no 3124 0.0658083046216609 4423 2977326 YHR190W ERG9
SGTC_2649 anisomycin 9.56 µM -1.51480528711247 0.0777749086457464 no 3125 0.0649108605801812 4553 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2019 4016004 108 µM -1.52487948311269 0.0764128126675958 no 3126 0.0636445800697034 4507 45595336
SGTC_685 1278-0033 54.9 µM -1.52529432398681 0.0763571150877956 no 3127 0.0635928514368351 4563 3590572
SGTC_3324 9138759 60.749 µM -1.53179469585405 0.0754883883643764 no 3128 0.0627865526920343 4526 45595710
SGTC_2735 sertaconazole 140 nM -1.53230196189998 0.0754209141151966 no 3129 0.0627239686045889 4639 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_22 0964-0034 14.468 µM -1.53262310696286 0.0753782206103822 no 3130 0.0626843723832408 4521 138402
SGTC_2906 7926292 26.41 µM -1.53644254612573 0.0748718700152115 no 3131 0.0622149393439138 4508 2966319
SGTC_358 0075-0058 9.45 µM -1.5364991273221 0.0748643884871478 no 3132 0.0622080058291796 4471 1069125
SGTC_2514 salinomycin 42.74 µM -1.53754970683716 0.074725577721699 no 3133 0.0620793762608583 4545 23682228 A polyether potassium ionophore.
SGTC_2819 7996655 46.38 µM -1.5417558540176 0.0741717953338366 no 3134 0.0615664667263827 4489 6456960
SGTC_2751 anetholtrithion 17.25 µM -1.54223354236735 0.0741091015046362 no 3135 0.0615084259277976 4470 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_455 paf C-16 10 µM -1.544303899256 0.073837846995448 no 3136 0.0612573642034537 4487 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_933 2914-0560 114 µM -1.54603292124371 0.0736118955810567 no 3137 0.0610483086266731 4528 463887
SGTC_1806 st050005 60.3 µM -1.5460507710398 0.0736095657005915 no 3138 0.0610461533246649 4562 5194765
SGTC_2363 9053361 176 µM -1.55143785307119 0.0729089789220697 no 3139 0.060398394893044 4548 6469797 YMR079W SEC14
SGTC_1805 st050013 60.3 µM -1.55306329279057 0.0726985970057289 no 3140 0.0602040072440408 4473 4037144
SGTC_2319 6033012 152.6 µM -1.5533418246869 0.0726625931093983 no 3141 0.060170746595957 4473 847246
SGTC_2196 6573537 42.6665 µM -1.55546370211441 0.0723887607653048 no 3142 0.0599178364397588 4548 2903087
SGTC_1297 1068-0111 14.1 µM -1.55740330296675 0.0721391439061009 no 3143 0.0596873812243022 4516 767057
SGTC_1654 st012436 41.8 µM -1.55861375820898 0.0719836991020009 no 3144 0.0595439123562452 4518 4323132
SGTC_2981 9013952 38.96 µM -1.56090681697484 0.0716899322545403 no 3145 0.0592728693198254 4471 2996344
SGTC_1749 st037932 54.2 µM -1.56494623754611 0.0711746748402171 no 3146 0.0587977579114042 4521 594497
SGTC_2902 5787006 60.46 µM -1.56629249528273 0.0710035831224953 no 3147 0.0586400785596973 4502 591003
SGTC_1911 st060208 74.3 µM -1.57050269732799 0.0704705599246357 no 3148 0.0581491036862497 4540 688783
SGTC_1822 st052468 42 µM -1.57372978056674 0.070064088952371 no 3149 0.0577749669419225 4554 2873678
SGTC_2903 5923464 63.88 µM -1.57709568489591 0.0696420568117378 no 3150 0.0573867549820631 4551 2876576
SGTC_2378 9074213 121.43 µM -1.58043307715019 0.0692255346682202 no 3151 0.0570038607889279 4513 657714
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.5827940542532 0.0689320347350336 no 3152 0.0567342061786343 4556 6708784 An antioxidant flavonoid
SGTC_607 4491-0986 66.8 µM -1.58500859065898 0.0686576119633908 no 3153 0.0564821912217641 4537 698981 YDR232W HEM1
SGTC_2829 7992743 58.44 µM -1.58863532071624 0.0682100125870209 no 3154 0.0560713745545445 4514 16462845
SGTC_3165 9101544 49.47 µM -1.59230453445549 0.067759465319294 no 3155 0.0556581472946646 4530 5002184
SGTC_2020 4017018 200 µM -1.60425524519959 0.0663079491640012 no 3156 0.0543289008918666 4566 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2217 6934799 96.0675 µM -1.60971255415233 0.06565317342716 no 3157 0.0537303114932525 4526 675606
SGTC_3128 9127691 49.47 µM -1.61028509652983 0.0655847705420132 no 3158 0.0536678156445201 4548 41316314
SGTC_3179 9107801 49.47 µM -1.6128827268009 0.0652751198971211 no 3159 0.0533849942912217 4532 4818259
SGTC_2761 levamisole 97.89 µM -1.61586160966736 0.0649214195027956 no 3160 0.0530621187447047 4558 26879 An alkaline phosphatase inhibitor.
SGTC_2849 9019321 12.99 µM -1.62182399688532 0.0642179411039216 no 3161 0.0524205193736251 4545 16489627
SGTC_3132 9126706 49.47 µM -1.62508895861526 0.0638352396810665 no 3162 0.0520718026034168 4567 850858
SGTC_2790 5423970 71.43 µM -1.62714604714732 0.063595031132114 no 3163 0.0518530416452955 4562 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_361 000s-0510 1.45 µM -1.62755467735088 0.0635473987637934 no 3164 0.0518096729672385 4459 660
SGTC_1050 3232-1156 69.3 µM -1.62756229782018 0.0635465107403153 no 3165 0.0518088644666668 4508 700529
SGTC_284 0988-0104 32.6 µM -1.62852509292536 0.0634343926038775 no 3166 0.0517067964914031 4542 4666532
SGTC_1677 st019204 53.9 µM -1.63306431265545 0.06290787034703 no 3167 0.0512277356433239 4559 3945625
SGTC_3253 9135987 49.47 µM -1.63362639709132 0.0628429095243751 no 3168 0.0511686608074399 4566 4182430
SGTC_850 0388-0143 75.9 µM -1.63647161958651 0.0625148850733688 no 3169 0.0508704603457483 4562 67273
SGTC_3263 9137018 49.47 µM -1.636786168429 0.0624787029710636 no 3170 0.0508375783991523 4514 43844957
SGTC_332 4112-0506 40.9 µM -1.65199543557029 0.060748606254886 no 3171 0.0492677406679166 4563 2790355
SGTC_2989 9073649 71.4286 µM -1.6539946464387 0.0605240039723259 no 3172 0.0490643002310733 4527 21367202
SGTC_3265 9137266 49.47 µM -1.66440902007065 0.0593644870539517 no 3173 0.0480153593622281 4557 17224265
SGTC_2612 dictamnine 15.46 µM -1.66646107155341 0.0591380828527042 no 3174 0.0478108077907156 4501 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.66723265318785 0.0590531291412943 no 3175 0.0477340761032319 4501 5355888
SGTC_726 3448-4391 34.2 µM -1.66749151792827 0.0590246487264471 no 3176 0.0477083548146851 4638 1356692
SGTC_2958 9077254 16.72 µM -1.67054398003167 0.0586896275619223 no 3177 0.0474058927608339 4577 16457351
SGTC_3058 9093861 49.47 µM -1.679757494715 0.0576874507116526 no 3178 0.046502254134277 4588 17217477
SGTC_2965 9082772 38.63 µM -1.68311315171689 0.0573258087098716 no 3179 0.0461765944870952 4554 16459634
SGTC_3168 9103419 49.47 µM -1.69135225585353 0.0564454399047744 no 3180 0.0453847725912257 4623 16649256
SGTC_2050 5263056 171 µM -1.69957561075741 0.0555774135955037 no 3181 0.0446053905755224 4566 763468 YGL055W OLE1
SGTC_3223 9129970 49.47 µM -1.70135261847854 0.0553912310412256 no 3182 0.0444383964247803 4596 17248386
SGTC_2618 avocadyne 43.43 µM -1.71398465948864 0.0540818904907247 no 3183 0.0432657716427479 4540 3015189
SGTC_2641 levomentholum 100 µM -1.71761606023547 0.0537100557771751 no 3184 0.0429333344889905 4607 16666
SGTC_1761 st044296 37 µM -1.72197070805153 0.0532668378181408 no 3185 0.0425374124230594 4613 1826700
SGTC_3039 9090270 49.47 µM -1.7232787702603 0.0531342704023845 no 3186 0.0424190624980664 4598 17173750
SGTC_648 0375-0473 33.3 µM -1.72585605325265 0.0528738375525427 no 3187 0.0421866563094937 4597 1713139
SGTC_523 1934-0222 13.7 µM -1.72640921178191 0.0528180734263681 no 3188 0.0421369098551638 4574 1361595
SGTC_3304 9125678 46.087 µM -1.7293562168263 0.0525217707067198 no 3189 0.0418726804875782 4546 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1244 0416-0015 52.5 µM -1.73421880029447 0.0520357548125999 no 3190 0.0414396342085109 4583 96201
SGTC_627 1391-0720 175 µM -1.74339438416189 0.0511283913483543 no 3191 0.0406323742950999 4601 997839
SGTC_2844 9010103 25.97 µM -1.75590099600102 0.0499119536643613 no 3192 0.0395526574433805 4559 2480525
SGTC_2996 9066192 71.4286 µM -1.75633111655373 0.0498705327743301 no 3193 0.0395159435516093 4580 6472854
SGTC_1596 piperlongumine 63 µM -1.75840213499359 0.0496714760360207 no 3194 0.039339555064342 4610 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1882 5615643 20 µM -1.75844834863236 0.049667041435917 no 3195 0.0393356263714723 4602 2253075
SGTC_1225 1216-0074 20.6 µM -1.75947057167129 0.0495690310067932 no 3196 0.0392488072100177 4601 4241466
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.76570051767404 0.0489750382688475 no 3197 0.0387230529501514 4619 688662
SGTC_1813 st051246 8.6015 µM -1.7693074346467 0.0486337454441017 no 3198 0.0384212917044428 4580 5291959
SGTC_476 mead acid 10 µM -1.79793805611286 0.0459916491677062 no 3199 0.0360934122665798 4684 5312531 An omega 9 fatty acid.
SGTC_1368 1852-0141 284 µM -1.79851171213101 0.0459399134988243 no 3200 0.0360479771601483 4584 2838987
SGTC_1867 st057372 64 µM -1.8006018646608 0.0457518067152339 no 3201 0.035882827535345 4614 688837
SGTC_2043 5101342 149 µM -1.80996553974875 0.0449166931982588 no 3202 0.0351505656426091 4641 678451
SGTC_612 0302-0167 22.4 µM -1.81253329491629 0.0446898407202761 no 3203 0.0349519170916159 4624 235821
SGTC_2893 9048488 25.97 µM -1.81994987168651 0.0440397891585072 no 3204 0.0343833195539035 4656 6467338
SGTC_118 0083-0097 135.343 µM -1.83209154691245 0.0429920675591726 no 3205 0.0334688912757586 4612 5207356
SGTC_1380 2291-0730 164 µM -1.83395937591377 0.042832692164504 no 3206 0.0333300123227158 4635 2999191
SGTC_306 1672-3436 11.6 µM -1.84026650812215 0.0422980518251262 no 3207 0.0328645599435656 4641 6797378
SGTC_2142 5622915 118.518 µM -1.84183922689837 0.0421655806846544 no 3208 0.0327493351452971 4651 5322196
SGTC_1055 3448-0672 86 µM -1.84248596747204 0.0421112028090711 no 3209 0.0327020486266277 4606 748378
SGTC_723 4182-0001 115 µM -1.8499760462862 0.0414855635564888 no 3210 0.032158501055237 4639 744821 YLR208W SEC13
SGTC_1024 4507-0395 26 µM -1.85022010417873 0.0414653050265317 no 3211 0.0321409162447229 4663 4201836
SGTC_2122 5258151 111.688 µM -1.85071298698866 0.0414244167121825 no 3212 0.0321054273539722 4650 2173356
SGTC_887 0885-0007 9.62 µM -1.85619202516556 0.0409720864244666 no 3213 0.0317130961990441 4650 5719458
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.86116460050537 0.0405650435724197 no 3214 0.0313604678656415 4728 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2125 5246583 200 µM -1.86343022420314 0.0403806767941968 no 3215 0.0312008804979776 4637 835267
SGTC_296 1222-0039 74.9 µM -1.86795202434635 0.0400147462864884 no 3216 0.030884379197657 4662 5984176
SGTC_1804 st050076 49.1 µM -1.87695720380501 0.0392940217667881 no 3217 0.0302619798157248 4669 3895976
SGTC_1944 st076371 56.9 µM -1.88237219976446 0.0388657453758425 no 3218 0.02989274888406 4634 24208455
SGTC_3236 9132701 49.47 µM -1.8876914346719 0.0384487518818153 no 3219 0.0295336934608987 4668 24282524
SGTC_782 0083-0095 30.5 µM -1.88994263432626 0.0382733741593694 no 3220 0.0293828163535408 4635 3591729 An indicator and reagent.
SGTC_2239 6685329 187.64 µM -1.89130484176477 0.0381675697228181 no 3221 0.029291831378279 4637 805680
SGTC_1180 1193-0155 285 µM -1.8977461226913 0.0376704932281825 no 3222 0.0288647667985115 4696 2921347
SGTC_2191 5911152 200 µM -1.90281169789112 0.0372833036715555 no 3223 0.0285325601322883 4668 2875902
SGTC_2629 bisabolol 100 µM -1.90332351683288 0.0372443640610255 no 3224 0.0284991720416245 4647 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2727 riluzole 51.77 µM -1.90552497364636 0.0370772540625909 no 3225 0.0283559321551672 4686 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_751 0833-0568 350 µM -1.91142604281378 0.0366323320015247 no 3226 0.0279749262987757 4667 6954252
SGTC_2203 7227154 166.4 µM -1.91849306436648 0.0361052579581584 no 3227 0.0275242603561558 4677 896304
SGTC_2773 thioridazine 9.09 µM -1.92351159658901 0.0357347485486797 no 3228 0.0272079157652247 4651 5452 An antipsychotic.
SGTC_3224 9130643 49.47 µM -1.92525685141361 0.0356066319458064 no 3229 0.0270986164265791 4645 17644395
SGTC_3026 9090633 49.47 µM -1.92538719910621 0.035597078442235 no 3230 0.0270904679217255 4668 25236842
SGTC_1757 st041620 31.8375 µM -1.92853296136001 0.0353671543122913 no 3231 0.0268944342341365 4648 5289815
SGTC_754 3474-0146 171 µM -1.9568307623413 0.0333531459676117 no 3232 0.0251836845163366 4670 24762078
SGTC_574 1315-0397 40 µM -1.96479387179949 0.0328037383485761 no 3233 0.0247190498887173 4661 6794277
SGTC_2617 dihydrotanshinone i 20.83 µM -1.96667803494922 0.0326748395790688 no 3234 0.0246101703610565 4627 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_119 0121-0043 24.815 µM -1.96738441868175 0.0326266224508825 no 3235 0.0245694546425027 4665 1092378
SGTC_2281 7943571 200 µM -1.97006559364339 0.032444141589732 no 3236 0.0244154267587726 4715 1244024
SGTC_3157 9099274 49.47 µM -1.97012251101226 0.032440276937515 no 3237 0.0244121657821539 4677 17217662
SGTC_2433 5607874 27.82 µM -1.97445089165858 0.0321474934470058 no 3238 0.0241652480845679 4649 2252428
SGTC_1861 st057647 17.4 µM -1.97983483391276 0.0317863566268209 no 3239 0.0238610454086888 4679 688668
SGTC_2963 9082507 9 µM -1.9841896433818 0.0314967082733985 no 3240 0.0236173513301785 4651 16459611
SGTC_1638 st008370 60.6 µM -1.9885560775188 0.031208480757496 no 3241 0.0233751117579079 4642 24207134
SGTC_1389 3405-0187 19 µM -1.98945210550043 0.031149604711623 no 3242 0.0233256616337101 4661 799890
SGTC_2929 9013348 24.6 µM -1.99313976581473 0.0309082630176483 no 3243 0.0231230723148584 4652 2995952
SGTC_2558 carylophyllene oxide 100 µM -2.00389378485739 0.0302132813933903 no 3244 0.0225407197349753 4733 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_709 3807-1509 243 µM -2.0114490561553 0.0297328067915318 no 3245 0.0221390230886724 4731 1886677 YPL242C IQG1
SGTC_3313 9133968 57.047 µM -2.0124496773807 0.02966965070062 no 3246 0.0220862781521192 4686 1494643
SGTC_122 0236-0016 402.397 µM -2.01408124005212 0.0295669103220214 no 3247 0.0220005023937155 4672 6808838
SGTC_3148 9097893 49.47 µM -2.02545582544611 0.0288588230358493 no 3248 0.0214102900368787 4654 17174100
SGTC_3318 9139014 38.6185 µM -2.03176324147072 0.0284722892368292 no 3249 0.0210888150697191 4675 16643984
SGTC_1293 1000-1278 195 µM -2.03390175367406 0.0283422177224351 no 3250 0.0209807510619357 4703 678847
SGTC_2892 9047358 58.44 µM -2.04409649666622 0.0277289186064388 no 3251 0.0204720075937779 4693 6466771
SGTC_2111 5486399 200 µM -2.04928830132542 0.0274208628441741 no 3252 0.0202169659617834 4656 689674
SGTC_1116 jasmonic acid 1.58368 µM -2.05368102200103 0.0271624543963304 no 3253 0.0200032872701085 4731 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_337 1315-0038 354 µM -2.05390012355542 0.0271496187945732 no 3254 0.0199926796888789 4693 1626437
SGTC_2189 6047310 154.431 µM -2.07474106674971 0.0259516249180307 no 3255 0.0190052695611602 4729 711535
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.07548663216542 0.0259096004961336 no 3256 0.018970728262282 4686 2374 Ca(2+)-ATPase inhibitor.
SGTC_655 k060-0012 42 µM -2.07667706451215 0.0258426188148596 no 3257 0.0189156874154947 4720 5994525
SGTC_1400 3771-8998 51.5 µM -2.07791269713629 0.0257732471824183 no 3258 0.0188587004235147 4698 670767
SGTC_2608 thymoquinone 42.66 µM -2.08655766546793 0.0252922432648357 no 3259 0.0184640687278778 4659 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_98 0074-0023 107.663 µM -2.09060529629681 0.0250696323947866 no 3260 0.0182817302972621 4706 3563821
SGTC_2176 5809774 33.9695 µM -2.09534569292085 0.024811011343057 no 3261 0.0180701366856528 4655 2870539
SGTC_2130 NSC 7 2.4545 µM -2.09959510203386 0.0245810826802768 no 3262 0.0178822370043454 4711 21448
SGTC_2729 fluphenazine 10.66 µM -2.10946590927179 0.024053882753737 no 3263 0.0174521928108021 4696 3372 An atypical antipsychotic.
SGTC_575 k072-0246 11.9 µM -2.11743163989803 0.023635389653717 no 3264 0.0171116156471763 4761 6796779
SGTC_637 1181-0519 7.26 µM -2.1266467379242 0.0231589149996881 no 3265 0.0167247230184199 4717 6252091 YGR060W ERG25
SGTC_1440 4100-1550 40 µM -2.1286642149242 0.0230556857501676 no 3266 0.0166410257659033 4732 742806
SGTC_312 4092-0653 6.84 µM -2.13471957073705 0.0227481725668038 no 3267 0.0163919617049585 4614 1148278
SGTC_2655 perillic acid 100 µM -2.1383665129837 0.0225646406300446 no 3268 0.0162435040579408 4743 5702197 An apoptosis inducer.
SGTC_2940 9060638 45.86 µM -2.14156946339674 0.0224044837374929 no 3269 0.016114071601953 4670 4027022
SGTC_3024 9090631 49.47 µM -2.14253243588406 0.0223565201597355 no 3270 0.0160753307243404 4721 25236383
SGTC_2610 ononetin 44.17 µM -2.14721387731012 0.0221245799649454 no 3271 0.015888129207989 4679 259632
SGTC_1039 k821-0043 94 µM -2.15885974695967 0.0215563852851999 no 3272 0.0154305247812219 4684 15992768
SGTC_2093 5331342 194.4 µM -2.15930016254921 0.0215351419554127 no 3273 0.015413443773723 4719 33839
SGTC_195 4234-0266 16.654 µM -2.16451227983258 0.0212850777480362 no 3274 0.0152125275927031 4741 2303354
SGTC_1136 pergolide 1.05886 µM -2.16988424611484 0.0210299185565014 no 3275 0.0150078080337712 4672 47811 A dopamine receptor agonist.
SGTC_2264 7948757 110.76 µM -2.17348919235709 0.0208601449844299 no 3276 0.0148717591836337 4687 2971411
SGTC_1294 1000-1494 117 µM -2.17816005644412 0.0206418992562861 no 3277 0.0146970613483254 4734 712797 YDL207W GLE1
SGTC_1893 st059353 36.1 µM -2.18212235315909 0.0204582804117531 no 3278 0.0145502519405084 4720 3112488
SGTC_994 3910-0338 138 µM -2.18398447958838 0.0203724658659894 no 3279 0.0144816942727109 4732 3479481
SGTC_1738 st035555 74 µM -2.18659963457632 0.0202524638620158 no 3280 0.0143858820273604 4695 5331140
SGTC_2923 7992654 58.14 µM -2.18864168027867 0.020159177374246 no 3281 0.0143114469400879 4685 2985126
SGTC_1573 oleylamine 1.06 µM -2.20425700960292 0.0194578002923225 no 3282 0.0137531372442852 4714 5356789 An amine of the fatty acid oleic acid.
SGTC_1854 st056233 32.9 µM -2.21199550601206 0.0191179709004426 no 3283 0.0134834877253532 4692 5393174
SGTC_641 4092-0595 30 µM -2.21970716761783 0.0187843530496598 no 3284 0.0132193259929467 4751 786260
SGTC_3178 9107506 49.47 µM -2.22555965172658 0.0185344840670264 no 3285 0.0130218456723044 4708 8897194
SGTC_1201 1889-3372 45.9 µM -2.26730276518756 0.0168330596285148 no 3286 0.0116858683354691 4677 5392199
SGTC_899 1083-0020 478 µM -2.26832925500045 0.016792961944386 no 3287 0.0116545730571682 4753 767123
SGTC_254 nsc-64875 3.808 µM -2.2695793842593 0.0167442386142826 no 3288 0.0116165578177499 4727 56993
SGTC_3209 9113616 49.47 µM -2.28050314615456 0.0163236107497039 no 3289 0.0112889322038302 4723 16649353
SGTC_2390 9097792 176.6 µM -2.28552423064761 0.0161333261038553 no 3290 0.0111410536485262 4755 4497149
SGTC_1160 4092-0570 10.5 µM -2.28729391077339 0.0160667148424356 no 3291 0.0110893368377632 4737 4994975
SGTC_2377 9073351 62.6 µM -2.2894614633889 0.0159854488167673 no 3292 0.0110262772535925 4720 7337946 YHR072W ERG7
SGTC_214 4373-3496 70 µM -2.29021167403057 0.0159574040708414 no 3293 0.0110045245112725 4756 3779166
SGTC_1296 1068-0102 11.9 µM -2.29978493254568 0.0156032189080284 no 3294 0.0107302037525479 4749 767053
SGTC_2778 tioconazole 65.09 nM -2.30333705486051 0.0154735265879389 no 3295 0.0106299431560733 4638 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_713 1488-1073 324 µM -2.313842213479 0.0150953720750209 no 3296 0.0103381894312743 4747 3312542
SGTC_2280 7785178 200 µM -2.3198152154492 0.0148839238888467 no 3297 0.0101754378111061 4735 2954328
SGTC_1460 k062-0059 9.15 µM -2.32087453088365 0.014846690528975 no 3298 0.0101468082534541 4627 1373085
SGTC_792 4534-1957 155 µM -2.3321112388588 0.0144566428479572 no 3299 0.00984741997979742 4726 1717904
SGTC_1904 st060225 78 µM -2.34860313665554 0.0139001657051573 no 3300 0.00942198981129333 4730 66595
SGTC_123 0083-0120 66.675 µM -2.3487875321694 0.0138940496466265 no 3301 0.00941732540961372 4725 16001701
SGTC_1897 st060201 15 µM -2.34981493088533 0.0138600151939125 no 3302 0.00939137366348525 4743 611878
SGTC_959 1222-0044 107 µM -2.37362425101209 0.0130911847968968 no 3303 0.00880723274100588 4749 6083612
SGTC_1863 st057641 20.1 µM -2.37661965794891 0.0129971202087932 no 3304 0.00873604672277498 4769 3921635
SGTC_1635 st007035 42.4 µM -2.38079535943681 0.0128669662853651 no 3305 0.00863765292322479 4711 3716403
SGTC_738 1315-0003 72.4 µM -2.38573508399084 0.0127144551291792 no 3306 0.00852251226260956 4752 6251474
SGTC_831 k061-1017 217 µM -2.40858923067433 0.0120290361295464 no 3307 0.00800715549833555 4761 1240153
SGTC_2233 sulbentine 40.3845 µM -2.42528877055223 0.0115486766859346 no 3308 0.00764810713256871 4757 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2088 5278280 127.392 µM -2.43411973875827 0.0113014552238047 no 3309 0.00746402795927135 4772 791502
SGTC_3274 9138298 49.47 µM -2.43588962426736 0.011252464673167 no 3310 0.00742760831342816 4735 17015756
SGTC_2789 5281112 71.43 µM -2.43884767625246 0.0111709976329873 no 3311 0.007367088759574 4731 765948
SGTC_2145 5634607 200 µM -2.45136234824008 0.0108319824574801 no 3312 0.00711583041066101 4764 308662
SGTC_1877 wortmannin 25 µM -2.4543664587266 0.0107519483681856 no 3313 0.00705665368871288 4764 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2786 7743617 45.45 µM -2.46783462408421 0.0103994319162053 no 3314 0.00679665520282108 4722 583674
SGTC_2933 9026794 32.47 µM -2.47729902930176 0.0101577771470705 no 3315 0.00661904692883006 4731 17586027
SGTC_196 k015-0023 18.111 µM -2.50408407896338 0.00950023393285884 no 3316 0.00613844277783732 4754 5211998
SGTC_1964 st076914 61 µM -2.52141718394724 0.00909483610288298 no 3317 0.00584415925904747 4780 24208661
SGTC_2149 5554786 194.827 µM -2.52781127696117 0.00894915741294787 no 3318 0.00573880147856421 4773 745063 YPR165W RHO1
SGTC_839 0122-0028 230 µM -2.55280129477134 0.00839922883032769 no 3319 0.00534302204214838 4777 759448
SGTC_260 nsc-65238 3.989 µM -2.57724787675639 0.00789019194809997 no 3320 0.00497952523303344 4773 3246252
SGTC_3038 9091290 49.47 µM -2.58544180602336 0.00772575288154697 no 3321 0.0048627144320041 4756 25236843
SGTC_798 1287-0182 476 µM -2.59245022126339 0.00758750617129878 no 3322 0.00476474854855307 4779 1649755
SGTC_2479 5617353 43.85 µM -2.6394023837418 0.00671624872627834 no 3323 0.00415261688897302 4763 2731746
SGTC_3124 9127567 49.47 µM -2.66053742470175 0.00635379502184487 no 3324 0.00390080282992498 4752 17592030
SGTC_2850 9015429 58.44 µM -2.67284795352817 0.00615075165256355 no 3325 0.00376051653697178 4758 6457570
SGTC_2089 5281248 129.67 µM -2.69149227685262 0.0058541819126265 no 3326 0.00355665726499849 4775 2737878
SGTC_1807 st050092 58.9 µM -2.74182737457402 0.00511590355901959 no 3327 0.00305492210689559 4779 5008496
SGTC_3319 9138450 16.7555 µM -2.75403723326239 0.00494981268342843 no 3328 0.00294325354894235 4770 2029690
SGTC_1875 nocodazole 6 µM -2.76015427857659 0.00486842267602765 no 3329 0.00288870354837374 4790 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1629 st005085 44.9 µM -2.78125475947022 0.0045967480815807 no 3330 0.00270746127405101 4763 24207091
SGTC_3210 9128157 49.47 µM -2.81809184936172 0.00415473773399162 no 3331 0.0024154993985297 4729 17590849
SGTC_1906 st060206 94.7 µM -2.83564196070331 0.00395784684887559 no 3332 0.00228668423842629 4783 5133468
SGTC_695 3505-6186 243 µM -2.86171868224623 0.00368071531588434 no 3333 0.00210675357841577 4771 1819379
SGTC_226 1,3-diallylurea 8.28947 mM -2.89866144433174 0.00331789170151015 no 3334 0.00187379657877939 4791 74537 YKL182W FAS1
SGTC_2730 imipramine 71.33 µM -2.91919758915607 0.00313041566491932 no 3335 0.00175466853770444 4776 3696 A tricyclic antidepressant.
SGTC_1148 3909-7663 27.7 µM -2.94389794150149 0.00291759031995803 no 3336 0.00162053429122774 4785 4084526
SGTC_1849 st056239 19.2 µM -2.98102757795514 0.00262215282906879 no 3337 0.00143641460238699 4781 5393181
SGTC_2606 farnesol 9.78 µM -3.05596471706807 0.0021067185434323 no 3338 0.00112168826642871 4780 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1864 st057645 30.4 µM -3.066648740146 0.00204124020371307 no 3339 0.00108236538500207 4806 688666
SGTC_190 3970-0790 3.722 µM -3.08325870139731 0.00194310546245232 no 3340 0.00102373539510022 4798 2832352
SGTC_2803 7707263 71.43 µM -3.08748336699721 0.00191883874683468 no 3341 0.00100929533953067 4778 2199229
SGTC_2802 7925815 54.55 µM -3.13624060161775 0.0016580355346875 no 3342 0.00085564373710482 4779 1262923
SGTC_1153 4055-0057 267 µM -3.15864991517669 0.00154936284631757 no 3343 0.000792508823582197 4800 882706
SGTC_1151 3909-8316 15.3 µM -3.23245430989332 0.00123577206839662 no 3344 0.000613658804479821 4800 800431
SGTC_2137 5261020 140 µM -3.23488007662249 0.00122652849920811 no 3345 0.000608469161227156 4802 763655
SGTC_1866 st057638 64 µM -3.35274752522628 0.000846701841578434 yes 3346 0.000400068295502009 4800 688802
SGTC_2792 7535235 81.82 µM -3.56100866316204 0.000427852717880184 yes 3347 0.000184716446421035 4781 1281891
SGTC_2565 isoliquiritigenin 100 µM -3.57200644756817 0.00041229758278792 yes 3348 0.000177128343825304 4779 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2486 5283202 22.39 µM -3.61330386293022 0.000358451736122395 yes 3349 0.000151160031113733 4797 1377751
SGTC_3272 9137413 49.47 µM -3.72287189298919 0.00024559413533742 yes 3350 9.84847376553009e-05 4803 17614870
SGTC_2943 9068529 45.32 µM -3.75656926965227 0.000218197959084042 yes 3351 8.61293032945708e-05 4794 3270634
SGTC_2090 5301565 104.445 µM -3.79715514927618 0.000188991528808283 yes 3352 7.31830937174107e-05 4807 2056344
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -3.85527286354375 0.000153478046296722 yes 3353 5.78003091035513e-05 4793 115019
SGTC_2591 skatole 100 µM -4.41984908960965 1.75605175874072e-05 yes 3354 4.93849251827135e-06 4802 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1625 st003711 30.1 µM -4.60393404878119 8.17681058890615e-06 yes 3355 2.07291900848656e-06 4806 24207034 YER133W GLC7
SGTC_3208 9114115 49.47 µM -4.6460530686005 6.83752288894516e-06 yes 3356 1.69172999389439e-06 4802 650895