SGTCid condition conc unit YHL008C|YHL008C.score YHL008C|YHL008C.strain.pval YHL008C|YHL008C.strain.significant YHL008C|YHL008C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2974 9094440 9.66 µM 6.75475805823663 3.33552866459947e-11 yes 1 7.15369010285703e-12 5 25236134
SGTC_2971 9092186 9.93 µM 6.02372111597001 2.84088994125485e-09 yes 2 8.52259854274061e-10 7 25236400
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 5.41305419133966 8.05294925043056e-08 yes 3 3.09793644025993e-08 6 5355888
SGTC_3208 9114115 49.47 µM 5.33596460474231 1.19951079549373e-07 yes 4 4.75189707663846e-08 15 650895
SGTC_1021 4476-0760 85.3 µM 4.77109732574791 1.8913199641218e-06 yes 5 9.16124873873176e-07 10 746768
SGTC_1783 st039459 87.517 µM 4.43307259291908 8.60258151297732e-06 yes 6 4.6449784706246e-06 14 729761
SGTC_674 0498-0004 451 µM 4.41584338987018 9.26795563758975e-06 yes 7 5.03084568416942e-06 14 4231473
SGTC_697 0508-1955 564 µM 4.2638261287354 1.76818965083791e-05 yes 8 1.004779192369e-05 24 6243113
SGTC_93 0109-0045 59.227 µM 4.20150721734337 2.2907611672387e-05 yes 9 1.32571896355225e-05 35 88733
SGTC_769 0302-0231 76 µM 4.1396058616787 2.95261882327855e-05 yes 10 1.73951515161928e-05 33 571869 YER009W NTF2
SGTC_2238 6671620 73.2395 µM 4.13104747585475 3.05725800230343e-05 yes 11 1.80556992789978e-05 23 729941
SGTC_1329 1447-1697 50.6 µM 3.89840422941205 7.68721754020546e-05 yes 12 4.84143409426191e-05 20 2840515
SGTC_333 3486-0131 40.1 µM 3.81473633364719 0.000105863694934673 yes 13 6.81642067916889e-05 14 6744690
SGTC_2282 7944268 200 µM 3.72488979498271 0.000148262055848011 yes 14 9.77002833744676e-05 40 2970414
SGTC_512 prima-1 270 µM 3.6602443670934 0.000188100628585902 yes 15 0.000125987414025502 32 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2241 6772625 37.8075 µM 3.52615677795943 0.000304609677867955 yes 16 0.000210818644476882 39 2285411
SGTC_1956 st077085 54 µM 3.46225425398823 0.000381179631975842 yes 17 0.000267835426053619 32 24208685
SGTC_1019 4262-0212 3.4 µM 3.39435684794838 0.000481858775707616 yes 18 0.000343949965435464 97 4677213
SGTC_891 0929-0073 133 µM 3.3333374048439 0.000592817186416183 yes 19 0.000429054053834223 44 5603632
SGTC_3339 9145883 14.936 µM 3.29605698758884 0.000671769627201536 yes 20 0.000490260616876613 31 2030670
SGTC_1778 st046819 58.9 µM 3.29194263774441 0.000681053250732041 yes 21 0.000497489518720191 51 671715
SGTC_1897 st060201 15 µM 3.2811734041598 0.00070591609556957 yes 22 0.00051688084026972 37 611878
SGTC_2449 5812982 45.77 µM 3.28032189870136 0.000707917232964838 yes 23 0.000518443540272216 26 776185
SGTC_1930 st074634 34.3 µM 3.2699604067078 0.000732690586808104 yes 24 0.000537812692548324 64 684253 YOR116C RPO31
SGTC_2292 7671323 168.05 µM 3.26410577567493 0.000747039283683655 yes 25 0.000549050805342853 69 937504
SGTC_7 0192-1582 4.227 µM 3.26129489370112 0.000754019863349241 yes 26 0.000554523173662211 104 252616
SGTC_834 0312-0008 75.7 µM 3.23871097696079 0.000812324289166442 yes 27 0.000600355901306189 69 6385573 YIL048W NEO1
SGTC_1070 indatraline 8.81 µM 3.14312546652469 0.00110796067248393 no 28 0.000835770877272165 58 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_738 1315-0003 72.4 µM 3.13922861379334 0.00112188239660399 no 29 0.000846966187855739 53 6251474
SGTC_1405 3909-7894 12 µM 3.139043568169 0.00112254745168557 no 30 0.000847501222484933 31 7104060
SGTC_2603 homopterocarpin 100 µM 3.1240001936989 0.0011778375714124 no 31 0.000892051696599961 95 101795 A weak amylase inhibitor.
SGTC_1483 3453-0561 55.9 µM 3.09318318572611 0.00129896385300712 no 32 0.000990109301805771 55 4546991
SGTC_764 1951-2361 146 µM 3.03439310566164 0.00156212820709863 no 33 0.00120510075205893 80 5438930
SGTC_756 0508-1999 28.3 µM 3.02542097056588 0.00160631580842277 no 34 0.00124143640840606 67 6753853
SGTC_1505 k297-0037 20.6 µM 3.01422580024427 0.0016630481092234 no 35 0.0012881798972555 61 4089396
SGTC_1080 nisoldipine 24.4 µM 3.00592976425329 0.00170625951721024 no 36 0.00132385073704373 65 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2166 5933061 31.504 µM 2.98242467782965 0.00183429837062299 no 37 0.00142987503766823 92 2877375
SGTC_2145 5634607 200 µM 2.98064476665551 0.00184434118518598 no 38 0.00143821123034154 37 308662
SGTC_74 000s-0487 160.283 µM 2.96580705036407 0.00193002556593826 no 39 0.0015094491209584 59 677548
SGTC_165 k038-0023 64.381 µM 2.95467318366994 0.00199667883521348 no 40 0.00156500212450067 142 46368543
SGTC_1000 4048-0884 8.67 µM 2.94302841510877 0.00206862049867003 no 41 0.00162509292357394 75 13040088
SGTC_2847 9005661 71.43 µM 2.93056799278357 0.00214819925934731 no 42 0.00169171470906059 27 2991449
SGTC_1125 tnp00248 1.32998 µM 2.92173356104451 0.00220629142510348 no 43 0.00174044588254306 109 24207736
SGTC_2690 usnic acid 100 µM 2.91739941440923 0.00223530868384335 no 44 0.00176481735124989 85 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_515 4092-1064 102 µM 2.89132243055985 0.0024173133270573 no 45 0.00191812156855648 121 717353
SGTC_185 k048-0037 25.491 µM 2.86075697031949 0.0026476447847691 no 46 0.00211315446012433 43 6827589
SGTC_3180 9109287 49.47 µM 2.85861851770491 0.00266447844117365 no 47 0.00212745065782719 59 18891271
SGTC_773 4358-1457 44.6 µM 2.84031503374244 0.00281256331440298 no 48 0.00225345005117518 106 1186886
SGTC_1866 st057638 64 µM 2.84002717960401 0.00281495037178058 no 49 0.00225548450912901 60 688802
SGTC_2759 disulfiram 3.38 µM 2.83757679169329 0.00283534456000866 no 50 0.0022728705302214 97 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_520 3584-0023 682 µM 2.82235351282616 0.00296505892147909 no 51 0.00238362976622304 86 1340790
SGTC_2467 5474540 200 µM 2.80582659587968 0.00311191483909681 no 52 0.00250938462581082 82 5413519
SGTC_3117 9124945 49.47 µM 2.79746790973599 0.00318865489198929 no 53 0.00257524416466927 46 17592065
SGTC_2230 bromochlorosalicylanilide 954.5 nM 2.78747641632147 0.00328261719688863 no 54 0.00265601603001057 28 77254
SGTC_1863 st057641 20.1 µM 2.76320018837919 0.00352137319326008 no 55 0.00286188246211602 72 3921635
SGTC_259 usnic acid 108.925 µM 2.74719710229822 0.00368717614301877 no 56 0.00300535001140695 79 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1769 st044406 64.4 µM 2.74112213783022 0.00375192858061078 no 57 0.003061487111674 70 670903
SGTC_2301 7769476 200 µM 2.70506175940467 0.00415771551144774 no 58 0.00341458457341406 70 977820
SGTC_3136 9095672 49.47 µM 2.69582116074791 0.00426782749927784 no 59 0.00351076768303585 87 17217380
SGTC_2567 aureobasidin a 60 nM 2.6931877395879 0.0042996814412157 no 60 0.00353862025355697 188 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3010 9080089 71.4286 µM 2.68428880779739 0.00440890164139538 no 61 0.00363421441962359 80 17027233
SGTC_3105 9121040 49.47 µM 2.66662522401534 0.0046330633573614 no 62 0.00383085287356258 24 41448907
SGTC_957 1187-1561 14.1 µM 2.6465596451533 0.00490000089552752 no 63 0.00406575819221567 98 1538454
SGTC_1789 tunicamycin 25 nM 2.59841010731256 0.00559722065254077 no 64 0.00468282817442728 135 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_632 0781-2353 4.65 µM 2.59802565258167 0.00560312532096605 no 65 0.00468807445557816 134 6811515 YHR007C ERG11
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.5809085008257 0.00587169030425146 no 66 0.00492703477543834 120 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2431 5490079 200 µM 2.57832294595427 0.00591323472010206 no 67 0.00496405816325088 127 5722345
SGTC_1752 st044819 83.042 µM 2.56964825571582 0.00605452952261578 no 68 0.00509009107344193 125 441209 YML126C ERG13
SGTC_2508 celastrol 40.54 µM 2.56398367355459 0.00614840245618201 no 69 0.00517392059683024 84 122724 Celastrol is a natural product and antioxidant.
SGTC_2423 st077119 87.2 µM 2.55012231551076 0.00638357012696021 no 70 0.00538425655395728 97 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1314 1222-0010 41.1 µM 2.54698381947303 0.00643790943337963 no 71 0.00543292356204389 82 3526027
SGTC_158 k038-0087 26.446 µM 2.51637791216779 0.006989645781505 no 72 0.0059283985588407 266 X158
SGTC_278 4092-0821 23.9 µM 2.51205361251717 0.00707087491537299 no 73 0.00600154259818865 132 877900
SGTC_3119 9125183 49.47 µM 2.50784214847642 0.00715078404068883 no 74 0.00607354588883759 59 22695334
SGTC_2641 levomentholum 100 µM 2.49989290225399 0.00730378791549661 no 75 0.00621154281857969 50 16666
SGTC_2841 9004761 38.96 µM 2.49388332795512 0.00742136623179884 no 76 0.00631770345731516 121 2991039
SGTC_355 1311-2252 105 µM 2.46789035363994 0.00794934559513596 no 77 0.00679559718257947 128 5338538
SGTC_1982 st072467 71.9 µM 2.46583530148793 0.00799246426892862 no 78 0.00683470853473757 162 3163533
SGTC_3336 9143619 71.43 µM 2.44676308682707 0.00840254404295134 no 79 0.00720727770442244 120 45595730
SGTC_192 3455-0609 60.9 µM 2.44587984685946 0.00842197456523703 no 80 0.00722495735329611 103 3769639
SGTC_1848 st056003 16.4 µM 2.42219460710007 0.00895794868506735 no 81 0.0077135432514642 127 146492
SGTC_1617 st002906 78 µM 2.35663137789279 0.0106003253575451 no 82 0.00922077150404048 163 5150859
SGTC_671 0560-0003 407 µM 2.35616807908666 0.0106128077112238 no 83 0.00923228044125733 122 3238678
SGTC_2308 7584454 197.62 µM 2.33511144646387 0.0111938026629033 no 84 0.00976879975715851 171 893577
SGTC_1974 st069448 26.9 µM 2.32979023749526 0.0113449311923995 no 85 0.00990862019976478 123 6323587 YNR016C ACC1
SGTC_2686 alizarin 95.37 µM 2.32552047044445 0.0114674766567251 no 86 0.0100220733126499 143 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1768 st044301 37.178 µM 2.32333596374607 0.0115306170651646 no 87 0.0100805556269433 149 3931349
SGTC_1421 4029-0249 71.4 µM 2.32108514019663 0.0115959898768736 no 88 0.0101411246093405 150 2894095
SGTC_413 propylparaben 100 µM 2.3188633782043 0.0116608339944717 no 89 0.0102012226918931 134 7175 A pharmaceutical preservative.
SGTC_285 1486-1325 46 µM 2.30860941609776 0.0119642001611245 no 90 0.01048263248285 134 22310230
SGTC_3108 9121785 49.47 µM 2.30179886964756 0.0121694543579974 no 91 0.0106732586694677 155 17140271
SGTC_2944 9067346 25.62 µM 2.2925441602958 0.0124532572707469 no 92 0.0109371311783509 180 6473075
SGTC_2692 st077426 47.7 µM 2.29224895433229 0.0124624035421014 no 93 0.0109456407685683 147 25238571
SGTC_1524 corynanthine 62.1 µM 2.29200942745424 0.0124698290004457 no 94 0.0109525495895571 146 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_684 1140-0066 328 µM 2.29187078644605 0.0124741286943955 no 95 0.0109565502308066 192 6813534
SGTC_2664 lyso-paf C-16 73.48 µM 2.28360564682622 0.0127327869854668 no 96 0.0111973588114144 150 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3249 9135183 49.47 µM 2.28203001859507 0.0127826195982925 no 97 0.0112437840210308 149 4902779
SGTC_506 n9-isopropylolomoucine 153 µM 2.26536297461796 0.0133201664671598 no 98 0.011745207234974 133 6610355
SGTC_1152 3909-8331 15.9 µM 2.24612406583752 0.0139648351465151 no 99 0.0123480311317094 138 16001939
SGTC_1914 st062367 72.6 µM 2.23953748146533 0.0141916386916766 no 100 0.0125604826898894 154 978205
SGTC_3341 9147222 25.867 µM 2.23386080464569 0.0143896494606632 no 101 0.0127461166144061 138 1939759
SGTC_1345 1488-0192 31.4 µM 2.23286402586 0.0144246629743802 no 102 0.0127789562654426 150 658348
SGTC_1341 1486-1360 280 µM 2.22804663977373 0.0145949173905593 no 103 0.0129387025074482 166 3976547
SGTC_2627 acetyl isogambogic acid 100 µM 2.22423908499968 0.0147307035086851 no 104 0.0130661813365951 195 6857789 A caspase activator and apoptosis inducer.
SGTC_2810 7959871 45.46 µM 2.21292301635508 0.0151406927249516 no 105 0.0134514767904185 213 2974535
SGTC_884 0851-0618 334 µM 2.20030561578572 0.0156093537370056 no 106 0.0138926095619838 176 9642473
SGTC_1017 4239-0030 168 µM 2.16646227312045 0.0169283463543662 no 107 0.015137939887168 203 1149593
SGTC_2506 ethyl hematommate 54.16 µM 2.16006416545216 0.0171881316617243 no 108 0.0153838513131061 150 3940691 An allergen.
SGTC_2638 epoxomicin 18 µM 2.15593423851562 0.0173576238800294 no 109 0.0155444002474089 179 9915668 A protesome inhibitor.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.15013698518349 0.0175979500493617 no 110 0.0157721904191407 206 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1006 4099-6547 255 µM 2.14945570421115 0.017626378290699 no 111 0.015799146911816 184 3146833
SGTC_2266 7929956 200 µM 2.14544815984948 0.0177943982008602 no 112 0.0159585160184867 196 2967153
SGTC_1773 st048542 73.5835 µM 2.1340433658787 0.0182800497787746 no 113 0.0164196155694672 221 3237138
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.13314650826918 0.0183187152150885 no 114 0.01645635479562 204 688664
SGTC_349 k015-0014 24 µM 2.12535804732506 0.0186574316127117 no 115 0.016778374042983 182 2196908
SGTC_2869 9037858 32.47 µM 2.12106454654528 0.0188464229887762 no 116 0.0169581854867625 140 27187042
SGTC_2557 derrustone 83.84 µM 2.12016431030495 0.0188862554873495 no 117 0.0169960955283295 243 629853 An antioxidant.
SGTC_1680 diphenhydramine 100 µM 2.11812059804311 0.0189769489656228 no 118 0.0170824277479739 201 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_638 3970-0837 4.09 µM 2.11293493687808 0.0192087360068332 no 119 0.0173031685387979 211 4118451 YLR208W SEC13
SGTC_412 gemfibrozil 100 µM 2.11260496401024 0.0192235661158022 no 120 0.0173172967484492 134 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2083 5306046 65.942 µM 2.11113797498392 0.0192896154824247 no 121 0.017380227096166 225 539837
SGTC_1671 st016596 74.5 µM 2.10712327420996 0.0194713592964429 no 122 0.0175534476886725 189 2829167
SGTC_1992 st073643 23.3 µM 2.09315827883236 0.0201149196434808 no 123 0.0181675138562716 156 3161292
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.08815542241961 0.0203498177868247 no 124 0.0183919084899809 173 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1713 st033146 12.748 µM 2.06723684131921 0.0213573455706798 no 125 0.0193559211449769 219 674619
SGTC_174 3553-0389 74.3 µM 2.05674965895861 0.0218781251240979 no 126 0.0198551563559247 182 738071
SGTC_199 4063-0024 41.6 µM 2.04778033966557 0.0223319992461131 no 127 0.020290763801738 159 306215
SGTC_2479 5617353 43.85 µM 2.04676595884339 0.0223838263383577 no 128 0.0203405347580701 238 2731746
SGTC_2148 5546263 113.568 µM 2.0448910162541 0.022479888619119 no 129 0.0204328019060896 199 792097
SGTC_19 0279-0214 38.434 µM 2.03472403574463 0.0230068655618767 no 130 0.0209393241562235 309 3566274 YBR002C RER2
SGTC_3190 9110366 49.47 µM 2.02030370324743 0.0237721177552956 no 131 0.021675947461747 155 17123768
SGTC_579 4491-1009 110 µM 2.00257724287027 0.024742031613948 no 132 0.022611342270512 290 1271041
SGTC_2034 5197015 53.07 µM 1.99145610389141 0.0253673156387203 no 133 0.0232153832587711 217 780676
SGTC_1530 rhein 70.4 µM 1.98363062545 0.02581519176139 no 134 0.0236485162577216 216 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3095 9117207 49.47 µM 1.97911033436386 0.0260769038808717 no 135 0.0239017925959919 156 17015229
SGTC_2272 7805186 180 µM 1.97890820104757 0.0260886584750533 no 136 0.023913171374569 180 2956062 YPR165W RHO1
SGTC_2044 5102272 200 µM 1.97677300316646 0.0262130968130246 no 137 0.0240336472949373 169 592666
SGTC_476 mead acid 10 µM 1.9766137785458 0.0262223961997696 no 138 0.0240426517458682 131 5312531 An omega 9 fatty acid.
SGTC_856 0433-0016 11.3 µM 1.9755667647462 0.0262836149306645 no 139 0.0241019329687424 230 3911780
SGTC_464 bw-b 70c 158 µM 1.97139108477228 0.026528955942556 no 140 0.0243395800041966 261 5353454
SGTC_2729 fluphenazine 10.66 µM 1.97057669842135 0.0265770273009739 no 141 0.0243861570426216 229 3372 An atypical antipsychotic.
SGTC_3284 9108171 64.8615 µM 1.95748722355338 0.0273597061398132 no 142 0.0251451062347514 192 8687505
SGTC_1806 st050005 60.3 µM 1.95411924901133 0.0275641733684073 no 143 0.0253435580783353 239 5194765
SGTC_530 4358-1714 28 µM 1.94388796361109 0.0281931336345869 no 144 0.025954481516565 287 1564641
SGTC_2671 danthron 100 µM 1.94255479813091 0.0282759619510743 no 145 0.0260349864492781 242 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_14 0354-0009 295 µM 1.93369140225194 0.0288318004767854 no 146 0.0265755407876415 240 1713507
SGTC_3294 9122953 26.2835 µM 1.93366063597078 0.02883374558866 no 147 0.026577433345572 237 16459826
SGTC_2839 9003951 25.97 µM 1.93167937306688 0.0289592352864303 no 148 0.0266995461191791 196 2990634
SGTC_1967 st070177 51.4 µM 1.93153605201545 0.0289683305669206 no 149 0.0267083976863092 210 5729214
SGTC_237 nikkomycin 200 µM 1.9250223820264 0.0293842064516106 no 150 0.0271132791028453 247 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1150 3909-7983 10.9 µM 1.92347687627661 0.0294836061277947 no 151 0.0272100939052553 279 23965914
SGTC_3038 9091290 49.47 µM 1.91390035236086 0.0301057649484714 no 152 0.0278164446895592 232 25236843
SGTC_2981 9013952 38.96 µM 1.9108873580313 0.0303037469568855 no 153 0.0280095290125844 260 2996344
SGTC_2463 5473429 200 µM 1.91018408796217 0.0303501133866069 no 154 0.0280547575900398 219 5399405
SGTC_2932 9016711 44.54 µM 1.90530222400765 0.0306735964007389 no 155 0.028370398276059 296 7117328
SGTC_2122 5258151 111.688 µM 1.90215595311867 0.0308835842560464 no 156 0.0285753846510753 264 2173356
SGTC_190 3970-0790 3.722 µM 1.90124337848891 0.0309447132880815 no 157 0.0286350708378479 214 2832352
SGTC_836 0330-0104 1.35 µM 1.89821815048914 0.0311480755131628 no 158 0.0288336753979047 235 46494820
SGTC_690 glyoxal 20.3 µM 1.89100047072953 0.0316377315299093 no 159 0.0293121406955573 333 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1181 1222-0449 220 µM 1.88957454119343 0.0317352169161506 no 160 0.029407442375961 241 658318
SGTC_2140 5586273 200 µM 1.88772163698664 0.0318622635912938 no 161 0.0295316650309848 189 854421
SGTC_2516 gossypol 71.55 µM 1.88553939850589 0.0320124299407592 no 162 0.0296785252251861 258 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3164 9100705 49.47 µM 1.88149852334684 0.0322920375788669 no 163 0.0299520679796368 182 17174235
SGTC_2407 paclitaxel 400 µM 1.88134657185615 0.0323025910311166 no 164 0.0299623948306501 296 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2017 5132927 60.65 µM 1.87704321411541 0.0326026548981742 no 165 0.0302560856455719 287 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2751 anetholtrithion 17.25 µM 1.86597579188665 0.0333849336207515 no 166 0.031022376241996 261 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_126 0417-1624 672.48 µM 1.86415778668475 0.0335149018255859 no 167 0.031149774730633 344 41912 YDL195W SEC31
SGTC_287 k060-0039 29.6 µM 1.853941760171 0.0342530078891838 no 168 0.0318737462909034 245 5861974
SGTC_556 4058-0063 51.5 µM 1.85263781612714 0.0343481719238025 no 169 0.0319671441992372 276 6615692
SGTC_2522 biochanin a 4.94 µM 1.84892341333529 0.034620446891272 no 170 0.032234436176167 240 5280373 A possible chelator.
SGTC_2219 9098279 200 µM 1.83875423767831 0.0353749538937421 no 171 0.0329756709649005 242 902349
SGTC_55 0767-0285 6.563 µM 1.83641939089239 0.0355500791774258 no 172 0.0331478269417935 332 3116166
SGTC_1827 berberine 7.24 µM 1.83214555085622 0.0358724797198034 no 173 0.0334648692352822 257 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1135 dihydrocapsaicin 536.708 nM 1.83070818164091 0.0359814456131607 no 174 0.033572055624478 304 107982 A Capsaicinoid.
SGTC_577 r071-0003 38.6 µM 1.8300733421891 0.0360296585609138 no 175 0.0336194862662503 390 4568517 YMR134W ERG29
SGTC_1999 st074831 12.5 µM 1.81783400758964 0.0369695647230684 no 176 0.0345447535744752 299 17112523
SGTC_1740 st038286 13.222 µM 1.8136488495454 0.0372955219057329 no 177 0.0348659023278916 293 716786
SGTC_2026 5148700 152 µM 1.81175210929104 0.0374440189980324 no 178 0.0350122539843497 267 79838
SGTC_1573 oleylamine 1.06 µM 1.80180882805271 0.0382304054252734 no 179 0.0357877441598042 311 5356789 An amine of the fatty acid oleic acid.
SGTC_583 1488-1091 88.9 µM 1.791995201343 0.0390196915028648 no 180 0.036566867344263 352 4303273
SGTC_1242 0402-0103 60.1 µM 1.78899168858048 0.0392638913646543 no 181 0.0368080770518787 265 432868
SGTC_1148 3909-7663 27.7 µM 1.7837971280569 0.0396891684435435 no 182 0.0372283182145249 282 4084526
SGTC_1698 5-fluorocytosine 1.055 µM 1.75870148820075 0.0417967885620171 no 183 0.0393141122487373 267 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2511 berberine 10.47 µM 1.75813199767471 0.0418456482203235 no 184 0.0393625262435679 260 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2121 5257820 149.641 µM 1.7524504653435 0.0423356339777028 no 185 0.039848190164526 311 791256
SGTC_1053 3366-3204 134 µM 1.73984571225124 0.0434392670580904 no 186 0.0409430566552657 341 3632071 YPR165W RHO1
SGTC_955 1216-0110 33 µM 1.73114371784186 0.0442146520538852 no 187 0.0417130673335708 399 3619719
SGTC_806 3966-4455 5.86 µM 1.72844619631875 0.0444572653923806 no 188 0.0419541296441159 279 714982
SGTC_770 0389-1121 67.2 µM 1.72304225696361 0.0449465185732358 no 189 0.0424404418335244 371 6753108
SGTC_114 0364-0001 490.298 µM 1.71775063571921 0.0454297936939991 no 190 0.0429210545287458 349 4003655
SGTC_86 0417-1630 471.922 µM 1.7107572347187 0.0460748910812981 no 191 0.0435629685743756 487 3634867
SGTC_576 1073-0113 22.7 µM 1.7077337358424 0.0463560586702243 no 192 0.0438428796994346 483 5439563
SGTC_125 0133-0007 11.75 µM 1.70276281296311 0.0468213177738666 no 193 0.0443062323295327 297 26541
SGTC_98 0074-0023 107.663 µM 1.69605023733948 0.0474555248022995 no 194 0.0449381832586596 349 3563821
SGTC_3004 9076122 71.4286 µM 1.69449130773688 0.0476037935856131 no 195 0.045085981021647 347 44782551
SGTC_1726 st035556 14.5795 µM 1.6930221220382 0.0477438662846224 no 196 0.0452256282311439 361 5919439
SGTC_1304 1165-0502 251 µM 1.68853694352892 0.0481735274816279 no 197 0.0456541017282146 389 767425
SGTC_2737 bleomycin 30.5 nM 1.68727466015765 0.048295005169604 no 198 0.0457752755612062 388 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_652 0437-0092 114 µM 1.68663407083083 0.0483567468863132 no 199 0.0458368682120254 287 3091274
SGTC_2236 dapsone 200 µM 1.67067548334545 0.0499153565096636 no 200 0.047392896975738 333 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_814 3342-0569 96 µM 1.66438163141501 0.0505409614548805 no 201 0.04801809423377 376 4346283
SGTC_1146 3579-1023 7 µM 1.66344643707508 0.050634449912873 no 202 0.0481115521211477 382 X1146
SGTC_865 0488-0499 301 µM 1.66267172713784 0.0507119995126969 no 203 0.0481890823135924 354 9634651
SGTC_89 0302-0250 142.109 µM 1.66165106199889 0.0508143139537345 no 204 0.048291379388911 373 4203518 YLR208W SEC13
SGTC_1417 3966-0327 90.4 µM 1.65722500567828 0.0512598978150616 no 205 0.0487369963938051 366 651118
SGTC_1802 st050112 57.9 µM 1.65379261921782 0.0516075815964686 no 206 0.0490848280675214 325 4662563
SGTC_62 0180-0423 3.232 µM 1.65230256168509 0.0517590995391369 no 207 0.0492364436825925 335 30102 YGL099W LSG1
SGTC_624 k048-0052 28 µM 1.6511860389986 0.0518728658026508 no 208 0.0493502964762289 325 6835531
SGTC_258 haloperidol 50.781 µM 1.65100573533332 0.0518912561735309 no 209 0.049368701894888 379 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3207 9114163 49.47 µM 1.63938000032624 0.0530880191894966 no 210 0.0505670720956024 406 849233
SGTC_3233 9132340 49.47 µM 1.63854846365515 0.0531744500901739 no 211 0.05065366648609 346 17682950
SGTC_73 0327-0325 16.231 µM 1.63270361191137 0.0537851227698641 no 212 0.0512656737139331 427 53298
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.63185183670392 0.0538745784428322 no 213 0.0513553511226404 359 165521
SGTC_3246 9135460 32.98 µM 1.62766290625201 0.054316226416647 no 214 0.0517981912643272 267 41446951
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.62664654433142 0.0544238142847286 no 215 0.0519060939835693 344 16623 A steroid.
SGTC_529 4076-0302 30.3 µM 1.62311185306911 0.0547992951060955 no 216 0.0522827481185844 377 5816522
SGTC_630 4356-0227 183 µM 1.62216611103988 0.0549001052159952 no 217 0.0523838928757595 328 779312
SGTC_1805 st050013 60.3 µM 1.6104911473398 0.0561566906114397 no 218 0.0536453382681943 315 4037144
SGTC_2504 purpurogallin 52.29 µM 1.61035524592562 0.0561714502079659 no 219 0.0536601624500873 334 5281571 An antioxidant.
SGTC_2008 4012253 172 µM 1.60595478789826 0.0566510178059032 no 220 0.0541419221197142 404 603940
SGTC_1482 3346-2049 8.48 µM 1.60433718048089 0.0568281154078134 no 221 0.0543198749037832 350 3826804
SGTC_950 1165-0508 94.1 µM 1.60405109038028 0.0568594822237536 no 222 0.0543513957420184 374 6148369
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.60324431946499 0.056948009738834 no 223 0.0544403620988049 375 390807
SGTC_1078 idebenone 36.1 µM 1.60202899796012 0.0570815726287608 no 224 0.0545745986253239 433 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2852 9023854 51.95 µM 1.60153044733738 0.0571364342323699 no 225 0.0546297409452148 393 19798528
SGTC_1363 1636-0063 10.4 µM 1.601516733664 0.0571379439013805 no 226 0.0546312583719353 395 6072185
SGTC_547 1120-0019 610 nM 1.59887050790268 0.0574298415610173 no 227 0.0549246891533246 372 3676939
SGTC_2424 5537928 59.2 µM 1.59830160476118 0.0574927486090753 no 228 0.0549879352233574 418 5382802
SGTC_3128 9127691 49.47 µM 1.59796675081926 0.0575298007608388 no 229 0.0550251884846116 320 41316314
SGTC_1614 st002383 48.6 µM 1.59739565815821 0.0575930364549297 no 230 0.0550887698447207 380 1947235
SGTC_2434 5670830 169.91 µM 1.59570598442781 0.0577804500695309 no 231 0.0552772259504498 392 1549830
SGTC_1654 st012436 41.8 µM 1.59524938371791 0.0578311770763292 no 232 0.0553282397537405 320 4323132
SGTC_3114 9122766 49.47 µM 1.59460123471666 0.0579032446547734 no 233 0.0554007181643598 362 17176985
SGTC_2327 6189656 200 µM 1.59154961970132 0.0582435022694452 no 234 0.0557429689117141 341 5349088
SGTC_1317 1273-0028 910 nM 1.5912694952332 0.0582748149272957 no 235 0.0557744694084592 366 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_622 1348-1566 26.3 µM 1.58715108642102 0.058736703676992 no 236 0.0562392149474533 405 7340407
SGTC_722 3534-0461 190 µM 1.58703247305253 0.0587500488783714 no 237 0.05625264507501 392 658262
SGTC_1129 3453-1384 223 µM 1.58074993067695 0.0594603055503716 no 238 0.0569676134370014 424 1084452
SGTC_706 4262-0057 46.9 µM 1.57715168434025 0.0598701171778103 no 239 0.0573803135964331 385 883298
SGTC_2063 5246145 200 µM 1.57209436458522 0.0604498416541317 no 240 0.0579643341274664 403 711240
SGTC_1655 st012546 55.1 µM 1.57080421366734 0.0605984336073976 no 241 0.058114066514709 352 720985 YLR208W SEC13
SGTC_592 k241-0073 46.5 µM 1.57002783055765 0.060687990437682 no 242 0.0582043183884595 397 4230158
SGTC_2693 st077581 40.7 µM 1.56788776609826 0.0609353857256124 no 243 0.0584536636897593 489 25238761
SGTC_2220 6782180 200 µM 1.56419289379359 0.0613643745680297 no 244 0.0588861377764216 284 833803
SGTC_2022 5136654 200 µM 1.56071651155058 0.0617701466185511 no 245 0.0592953268330044 392 1713771
SGTC_3126 9127922 49.47 µM 1.55647279067152 0.0622683200083473 no 246 0.0597978539613451 403 45595682
SGTC_2939 9044578 71.43 µM 1.55463152151932 0.0624854402842143 no 247 0.0600169260355521 391 2653634
SGTC_2268 7933382 153.85 µM 1.55437017300405 0.0625163059689553 no 248 0.0600480718495125 465 935025 YOR257W CDC31
SGTC_3048 9093155 49.47 µM 1.55265203412272 0.0627195169872382 no 249 0.0602531436582708 313 25236002
SGTC_779 1360-0071 233 µM 1.55201219027972 0.0627953252418208 no 250 0.0603296534056042 422 7566
SGTC_2310 7668677 200 µM 1.54925509994575 0.0631228003438119 no 251 0.0606602043321284 391 2197143
SGTC_1358 1509-0022 2.48 µM 1.54550183712659 0.0635707321589031 no 252 0.0611124624384595 395 3258434
SGTC_3351 9150312 21.596 µM 1.5435722634975 0.0638019771191611 no 253 0.0613459943354942 413 4904905
SGTC_2135 5326629 150.42 µM 1.54295494379777 0.0638760962519331 no 254 0.0614208541522902 381 5020077
SGTC_2647 atorvastatin 60.16 µM 1.54176759605448 0.0640188446477207 no 255 0.0615650395154308 384 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_410 α-linolenic acid 100 µM 1.54109313269608 0.0641000421255413 no 256 0.0616470604946638 425 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_929 2805-0021 398 µM 1.54033840611178 0.0641909972524389 no 257 0.0617389433543999 378 3098024
SGTC_1983 st071813 46.9 µM 1.53564788091172 0.0647585221232397 no 258 0.062312382087972 397 11838595
SGTC_84 0443-0269 128.823 µM 1.52904291879585 0.0655642788102715 no 259 0.0631269022538028 420 6150058
SGTC_2050 5263056 171 µM 1.52739156275782 0.0657669418640694 no 260 0.0633318366115255 474 763468 YGL055W OLE1
SGTC_2263 7948595 193.29 µM 1.52651035644322 0.0658752866309914 no 261 0.0634414066180742 322 2971371
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.5227555447023 0.066338493722186 no 262 0.0639099378931639 419 3256 An antibiotic and ribosome inhibitor.
SGTC_1272 0839-0021 27 µM 1.52220626774033 0.0664064654537952 no 263 0.0639787025722148 422 5027250
SGTC_2900 5328528 85.29 µM 1.52130489416288 0.0665181251496433 no 264 0.0640916713281452 469 795359
SGTC_1250 0485-0349 40.2 µM 1.51915765749626 0.0667847044398825 no 265 0.0643614082649122 423 6842794 YDL195W SEC31
SGTC_2519 cryptotanshinone 88.04 µM 1.5146255840857 0.0673500739746352 no 266 0.0649336247017295 362 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2087 5276107 200 µM 1.51144425308035 0.0677491453318441 no 267 0.065337650858929 384 144405
SGTC_1067 clotrimazole 1.36 µM 1.50959005196615 0.0679825804469408 no 268 0.0655740306586812 446 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1076 itraconazole 331 nM 1.5083952322471 0.0681333312908171 no 269 0.0657267012703986 422 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_391 gliotoxin 8.33 µM 1.50252068967453 0.068878280496858 no 270 0.0664813443744866 451 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1702 st027038 51 µM 1.50084881182682 0.0690914345762433 no 271 0.0666973351716461 440 5521182
SGTC_2886 9058944 51.95 µM 1.50045883087429 0.0691412277739895 no 272 0.0667477950446904 224 4949929
SGTC_1273 0849-0096 14.1 µM 1.49890845211016 0.0693394553585592 no 273 0.0669486917000954 441 5286025
SGTC_2115 tiliquinol 12.7705 µM 1.49877135093478 0.069357005821148 no 274 0.0669664796294711 382 71208 A bioactive hydroxyquinoline.
SGTC_2694 st077685 81.9 µM 1.49821837334639 0.0694278277852341 no 275 0.0670382617573765 420 2838096
SGTC_871 0574-0004 149 µM 1.49596529065906 0.0697169646430821 no 276 0.0673313501935356 475 9551173
SGTC_487 nimodipine 119 µM 1.4950153998975 0.0698391410095882 no 277 0.0674552115462815 288 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2877 9040724 71.43 µM 1.48980004940441 0.0705128852477128 no 278 0.0681384090736177 412 6463895
SGTC_338 4055-0136 114 µM 1.48872427692342 0.0706524783027108 no 279 0.0682799947328719 432 2900563
SGTC_2569 tetrandrine 100 µM 1.48466890074467 0.0711806169251835 no 280 0.0688157768892911 383 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1306 1185-0270 9.02 µM 1.4822571040089 0.0714961437071376 no 281 0.0691359487128499 470 1548076
SGTC_2920 7982904 15.77 µM 1.48140932752527 0.071607309874268 no 282 0.0692487653345108 370 6456808
SGTC_2270 7924575 90.91 µM 1.48116780320838 0.0716390044303755 no 283 0.0692809317760802 447 1262135
SGTC_786 4544-0069 423 µM 1.48099102090206 0.0716622098956912 no 284 0.0693044831091256 452 748821 YLR208W SEC13
SGTC_2460 5552655 174.22 µM 1.47972382215088 0.0718287185641382 no 285 0.0694734827406081 432 5401989
SGTC_2743 auranofin 4.32 µM 1.47239454249061 0.0727976054354197 no 286 0.0704571830308003 403 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1954 st077032 68.9 µM 1.47199456456865 0.072850766660765 no 287 0.0705111726841381 389 698907
SGTC_1094 duloxetine 25.4 µM 1.46838812180197 0.0733314433550076 no 288 0.0709994131223503 448 60834 A selective serotonin reuptake inhibitor.
SGTC_1936 st074407 74.3 µM 1.46464338751652 0.0738331153713406 no 289 0.0715091190012955 483 809813
SGTC_1572 epiandrosterone 68.9 µM 1.46394667349623 0.0739267410010693 no 290 0.0716042596726469 472 441302 A steroid.
SGTC_2049 5262831 67.185 µM 1.46206874625124 0.0741795519099655 no 291 0.0718611861010546 429 763417
SGTC_2717 st081029 62.2815 µM 1.4612979914718 0.0742835036244547 no 292 0.071966840420457 392 5292846
SGTC_718 1130-0073 349 µM 1.46052218444896 0.0743882490385404 no 293 0.0720733075356603 461 6740020
SGTC_2315 7733312 200 µM 1.45811074815419 0.0747145486508154 no 294 0.0724050096393161 407 726316
SGTC_1941 st076221 61.8 µM 1.45596338626972 0.0750060337855396 no 295 0.0727013707004689 518 2828568
SGTC_2763 lisinopril 49.32 µM 1.45353305706502 0.0753369745868434 no 296 0.073037904150418 394 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1362 1611-0397 101 µM 1.44699944000577 0.0762321827302055 no 297 0.0739485402049477 454 27816
SGTC_3201 9113999 49.47 µM 1.44318358226876 0.0767587470675996 no 298 0.0744843815614002 455 16649224
SGTC_2212 7123476 200 µM 1.44285466085884 0.0768042653020814 no 299 0.074530708713408 351 1085715
SGTC_1226 3909-7979 35.4 µM 1.43822377890896 0.0774472964827955 no 300 0.0751852851863867 511 6615510
SGTC_2178 5812956 200 µM 1.43059600608064 0.0785153695569023 no 301 0.076273016394674 423 5403383
SGTC_2324 6149169 200 µM 1.42910863136307 0.0787249328655527 no 302 0.0764865065342168 419 2888231
SGTC_1144 3486-0183 12.5 µM 1.42816549069592 0.0788580358709121 no 303 0.0766221154359897 487 6744069
SGTC_527 4476-4215 268 µM 1.42753258623289 0.0789474515894992 no 304 0.076713219692738 472 4418754
SGTC_394 menadione 8.33 µM 1.42401477917243 0.0794458419230972 no 305 0.0772210969416935 476 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_841 0251-0215 91.2 µM 1.42115008976739 0.0798534570269371 no 306 0.0776365653749837 547 3888614
SGTC_974 1326-0144 138 µM 1.42076751045779 0.0799080135353545 no 307 0.077692179404248 495 5411856
SGTC_2589 lobaric acid 100 µM 1.41745073516918 0.0803821737694536 no 308 0.0781755941014336 466 73157 A novel microtubule depolymerizer.
SGTC_3017 9080681 49.47 µM 1.41612541482639 0.0805722325194359 no 309 0.0783693941195876 448 16451914
SGTC_1291 0993-0025 5.79 µM 1.41591156354292 0.0806029318323978 no 310 0.0784006994418762 461 4353356
SGTC_580 1123-0028 41 µM 1.41372859905751 0.0809168117507007 no 311 0.0787208024428922 533 1677248 YPR107C YTH1
SGTC_1737 st035557 69.7 µM 1.41366521483136 0.0809259392855694 no 312 0.0787301116788974 393 5716916
SGTC_2443 5493264 126.67 µM 1.41259427150956 0.0810802761377194 no 313 0.0788875271821693 466 5340055
SGTC_2595 hexamethylquercetagetin 100 µM 1.40667073618268 0.0819379491622152 no 314 0.0797625235586374 450 386331
SGTC_231 b-estradiol 524 µM 1.40556883023337 0.0820982463594987 no 315 0.0799260985805122 404 450 A steroid.
SGTC_480 am 92016 50 µM 1.4053644385157 0.082128005724657 no 316 0.0799564678606469 422 2129 K+ channel blocker.
SGTC_3090 9117696 49.47 µM 1.40442134525804 0.0822654250437577 no 317 0.0800967091811291 432 7923821
SGTC_334 1502-1024 68.5 µM 1.40399276387809 0.0823279313812034 no 318 0.0801605021760206 490 3296216
SGTC_1404 3909-7820 48.3 µM 1.40301539268191 0.0824706095918136 no 319 0.0803061244596701 463 23741373
SGTC_2819 7996655 46.38 µM 1.40008457146816 0.0828995716299943 no 320 0.0807439973117944 416 6456960
SGTC_2967 9089538 49.85 µM 1.39859348085366 0.0831184544278825 no 321 0.0809674611912284 527 728216
SGTC_1371 2421-0008 32.7 µM 1.39770077098018 0.0832497064912956 no 322 0.0811014713279155 500 2827552
SGTC_2302 7771753 200 µM 1.39404767712999 0.0837884321569137 no 323 0.0816516038988383 533 2203047
SGTC_3083 9117465 49.47 µM 1.39381999849451 0.0838220946557931 no 324 0.0816859837557483 494 16420915
SGTC_1346 1488-2224 62.4 µM 1.38329682339368 0.0853890631302629 no 325 0.0832869358259746 501 3722427
SGTC_3079 9117512 49.47 µM 1.38291237334069 0.0854467228717521 no 326 0.0833458679408838 465 7185044
SGTC_1495 4469-0029 237 µM 1.38180238279639 0.0856133626695849 no 327 0.0835161936140396 631 793680
SGTC_3258 9138477 49.47 µM 1.38171707163889 0.0856261802594314 no 328 0.0835292952452744 460 4970355
SGTC_2025 5147754 141 µM 1.37842613010175 0.0861217257941871 no 329 0.0840358802045397 459 315777 YLR208W SEC13
SGTC_1443 4112-3303 14 µM 1.37691371753337 0.0863501810843537 no 330 0.0842694627959462 510 704433
SGTC_1893 st059353 36.1 µM 1.37625385491248 0.0864499975524211 no 331 0.0843715269611345 516 3112488
SGTC_935 2996-0153 430 µM 1.37282376532554 0.086970252384221 no 332 0.084903570374979 477 23738523
SGTC_1479 0549-0158 134 µM 1.3727603601756 0.0869798912535264 no 333 0.0849134288109315 546 5440202
SGTC_2375 9072683 200 µM 1.37159251719585 0.0871575698159596 no 334 0.0850951622779445 556 16798029
SGTC_2938 9059746 27.26 µM 1.36736789210435 0.0878025787091327 no 335 0.0857550105399174 456 6471769
SGTC_232 clozapine 119 µM 1.36725550370682 0.087819786477208 no 336 0.085772616747351 499 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3155 9099265 49.47 µM 1.3672376947941 0.0878225134276116 no 337 0.0857754068513799 451 25236499
SGTC_840 0245-0196 390 µM 1.36664130499391 0.0879138707746122 no 338 0.0858688818645661 554 3827528
SGTC_1407 3909-7909 12.3 µM 1.36574314198745 0.0880515886471243 no 339 0.086009799063131 513 4411780
SGTC_1935 st074532 41.6 µM 1.36395935860159 0.0883255780425924 no 340 0.0862901785508256 589 2829742
SGTC_3230 9131665 49.47 µM 1.36322128642642 0.088439131690199 no 341 0.0864063902848539 349 15943720
SGTC_956 1185-0240 191 µM 1.36273422446834 0.0885141265456995 no 342 0.0864831437576282 478 1416193
SGTC_504 lovastatin 124 µM 1.3582521434716 0.0892064755207096 no 343 0.0871918449958685 429 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1611 st001856 99.4 µM 1.35693434813256 0.0894108004930642 no 344 0.0874010358972534 488 647478
SGTC_3326 9140064 16.379 µM 1.35558177830627 0.089620879076167 no 345 0.0876161363628272 476 1868434
SGTC_2127 5253358 187.912 µM 1.35525660197335 0.0896714395295659 no 346 0.0876679083118536 454 20612
SGTC_2502 avocadyne acetate 18.59 µM 1.35332391968117 0.0899723827551742 no 347 0.0879760854208926 572 3952079
SGTC_2531 methyl deoxycholate 70.07 µM 1.34939416203149 0.0905866094265493 no 348 0.0886051974867612 499 16667744 Haematoxylin.
SGTC_553 k007-0256 45.7 µM 1.34886464828478 0.0906696105696815 no 349 0.0886902225034212 530 6287000
SGTC_1423 4048-0112 5.59 µM 1.34500458026527 0.091276381445665 no 350 0.0893118777223647 512 X1423
SGTC_822 1487-0950 154 µM 1.34391853907519 0.091447639633604 no 351 0.089487365165594 495 1958375
SGTC_1258 0671-0043 57.1 µM 1.34302022560481 0.0915894748556284 no 352 0.08963271239812 528 4298767
SGTC_2420 aureobasidin a 50 nM 1.34266830495489 0.0916450842240627 no 353 0.0896897010315456 554 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3068 9116768 49.47 µM 1.34138690895076 0.0918477776842151 no 354 0.0898974328396303 480 41904888
SGTC_2553 4-methylesculetin 85.09 µM 1.34026867241667 0.0920249334541598 no 355 0.0900790062662955 515 5319502
SGTC_167 3672-0051 66.205 µM 1.34019850506514 0.0920360580936312 no 356 0.0900904087540507 476 3237971
SGTC_1916 st067606 49.2 µM 1.33577427325903 0.0927395075439804 no 357 0.0908115321453165 570 19590279
SGTC_1469 k284-2957 126 µM 1.33332093722315 0.093131295852494 no 358 0.0912132528296259 491 23884841
SGTC_1313 1220-0047 237 µM 1.3272743977266 0.0941021250459917 no 359 0.0922089648709074 580 3528706
SGTC_2365 9042475 200 µM 1.32698163900033 0.0941493190318693 no 360 0.0922573782348878 552 6464479
SGTC_3137 9097352 49.47 µM 1.32635250011167 0.0942507980467314 no 361 0.0923614822727958 573 44120435
SGTC_3055 9094636 49.47 µM 1.32499872513722 0.0944694331455663 no 362 0.0925857870761529 493 25236176
SGTC_1171 0368-0077 21.4 µM 1.32477380317067 0.094505794312736 no 363 0.092623093039481 486 3239779
SGTC_1871 st057448 67.3 µM 1.32276093160531 0.0948316571127956 no 364 0.09295744666547 551 691747
SGTC_2027 5150920 200 µM 1.31929910855073 0.095394025097177 no 365 0.0935345678707376 521 786715
SGTC_2861 9024595 19.48 µM 1.31923075996463 0.0954051528828787 no 366 0.0935459888546827 397 16482810
SGTC_1882 5615643 20 µM 1.31450129916129 0.0961774755499102 no 367 0.0943387805921639 482 2253075
SGTC_3029 9088683 49.47 µM 1.31179598702742 0.0966213152926272 no 368 0.0947944896543317 524 25236615
SGTC_930 2810-3379 265 µM 1.31116650132421 0.0967248055995318 no 369 0.0949007585988908 603 1015764
SGTC_2776 terbinafine 19.92 µM 1.30860266398912 0.0971471531494318 no 370 0.0953344890353924 523 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2726 cimetidine 79.27 µM 1.30779367583011 0.0972807003521385 no 371 0.0954716499150166 451 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_408 cantharidin 100 µM 1.30671348479599 0.0974592274722498 no 372 0.0956550185870549 569 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2727 riluzole 51.77 µM 1.30625270781095 0.0975354548434905 no 373 0.0957333169421508 481 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_136 0097-0015 404.482 µM 1.3060274922634 0.0975727286620825 no 374 0.0957716042487389 595 4861337
SGTC_3002 9075603 71.4286 µM 1.30475757192004 0.0977830996478565 no 375 0.0959877053022058 565 20105405
SGTC_137 0438-0332 85.389 µM 1.3027194570945 0.098121422021007 no 376 0.096335278430938 685 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2754 granisetron 64.02 µM 1.30102960541681 0.098402583182938 no 377 0.0966241606161293 566 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3267 9137951 49.47 µM 1.30050309830139 0.0984903049976014 no 378 0.0967142975291138 468 16643986
SGTC_2523 spermine 47.74 µM 1.29911868659244 0.0987212362299954 no 379 0.0969516005546738 524 1103 A DNA binding polyamine.
SGTC_2030 5175110 200 µM 1.2981719751435 0.0988793834617961 no 380 0.0971141229795244 546 2831986
SGTC_117 lucigenin 22.078 µM 1.29633149057493 0.0991873649481854 no 381 0.0974306519281915 610 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_828 2074-0507 139 µM 1.29590105328977 0.0992594942133488 no 382 0.0975047881629632 583 X828
SGTC_1324 1418-0026 34.4 µM 1.29483058253142 0.0994390414866078 no 383 0.0976893397427852 573 1372513
SGTC_2071 5230951 39.92 µM 1.29152910404849 0.0999942848175762 no 384 0.0982601348939927 583 1799272
SGTC_845 0330-0138 4.51 µM 1.28930126880296 0.100370239800895 no 385 0.0986466850304345 555 9039800
SGTC_3216 9129716 49.47 µM 1.28811821539703 0.100570303030709 no 386 0.0988524077237758 513 8056934
SGTC_3254 9136651 49.47 µM 1.28501291369966 0.101096816515199 no 387 0.0993938857081044 582 16454030
SGTC_1746 st038117 42 µM 1.28488855101526 0.10111794435294 no 388 0.0994156161568614 562 2898218
SGTC_895 0964-0006 13.7 µM 1.282077633907 0.101596346606723 no 389 0.09990770699889 547 6738897
SGTC_1747 st037496 66.6 µM 1.272288657556 0.103275236887493 no 390 0.101635288550569 597 723305
SGTC_2532 xanthone 78.9 µM 1.27211548786168 0.103305117167931 no 391 0.101666044529632 512 7020 An insecticide.
SGTC_2412 st077135 33.4 µM 1.27014952253897 0.103644782973352 no 392 0.102015687065025 575 13258915
SGTC_728 3030-5151 22.5 µM 1.26750289421783 0.104103327732133 no 393 0.102487764697906 528 3125388
SGTC_2707 st078556 66.6 µM 1.26600325146763 0.104363802038464 no 394 0.102755959084814 549 17250899
SGTC_740 k014-0057 261 µM 1.26591891691628 0.104378464197151 no 395 0.102771056512486 632 4012779
SGTC_441 propafenone 146 µM 1.264613203026 0.104605662290542 no 396 0.103005008899596 506 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1978 st071761 42 µM 1.26035525639984 0.105349046036351 no 397 0.103770617451823 539 5147680
SGTC_739 1486-1183 203 µM 1.25980180271125 0.105445952027581 no 398 0.103870434660741 590 4346692
SGTC_2658 polymyxin b sulfate 77.05 µM 1.25799315588892 0.105763083421072 no 399 0.104197115722129 608 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_18 0111-0177 500 nM 1.25681796680363 0.105969512397858 no 400 0.104409779298768 689 721752
SGTC_1416 3966-0321 25.3 µM 1.25669236733754 0.105991591903381 no 401 0.1044325265132 598 582530 YLR208W SEC13
SGTC_3043 9092303 49.47 µM 1.2519506765526 0.106827581072052 no 402 0.105293918629561 528 25236084
SGTC_1861 st057647 17.4 µM 1.24923102636099 0.107309213734557 no 403 0.105790293509077 602 688668
SGTC_1578 josamycin 24.2 µM 1.24909501794501 0.107333340990582 no 404 0.105815161316822 532 5282165 A P450 substrate.
SGTC_3103 9120822 49.47 µM 1.24628899787945 0.107831988705368 no 405 0.10632915778168 622 17141819
SGTC_3195 9113082 49.47 µM 1.24431912426225 0.108183043283365 no 406 0.106691067621509 546 17018038
SGTC_2634 4'-methoxyflavone 100 µM 1.24314342110963 0.108392958999666 no 407 0.106907493783112 549 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_631 k072-0230 41.5 µM 1.24111265310367 0.108756232155776 no 408 0.1072820679622 639 5773147
SGTC_2977 9011197 71.43 µM 1.23341489517742 0.110141190164985 no 409 0.108710505280046 515 2704722
SGTC_1064 honokiol 6.76 µM 1.2305937689002 0.110651913482859 no 410 0.109237418451394 601 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2368 9071271 200 µM 1.22992411826224 0.110773392717655 no 411 0.109362760837637 580 27209959
SGTC_703 3875-0075 71.8 µM 1.22879825003798 0.110977848301675 no 412 0.109573728909775 624 2850814
SGTC_1126 isoteolin 1.0172 µM 1.22160765840074 0.112290023904506 no 413 0.110928015564115 593 133323
SGTC_2233 sulbentine 40.3845 µM 1.22115544564958 0.112372914978448 no 414 0.111013584967374 670 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1844 rapamycin 4 nM 1.21955555209143 0.112666528088266 no 415 0.111316702348522 717 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1627 st003713 25.6 µM 1.21213161382066 0.114036141399967 no 416 0.112731001963271 685 16195070 YER133W GLC7
SGTC_986 1493-0483 84 µM 1.21197426802689 0.114065297309141 no 417 0.112761115391503 607 40079
SGTC_1720 st037298 9.481 µM 1.21165452936943 0.114124560699278 no 418 0.112822325868463 567 597396
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.2073939435767 0.114916351923807 no 419 0.113640233424047 597 688662
SGTC_2187 6125751 200 µM 1.20696431953832 0.114996409992437 no 420 0.11372294265697 623 874498
SGTC_1952 st077036 64.1 µM 1.2065819767997 0.115067690802356 no 421 0.113796585589778 621 2937007
SGTC_256 clotrimazole 625 nM 1.20510028380837 0.115344222142633 no 422 0.114082295134996 609 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.20483625893294 0.115393547175679 no 423 0.114133259696792 544 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2089 5281248 129.67 µM 1.20363073352978 0.115618953480603 no 424 0.114366167599352 633 2737878
SGTC_3086 9117350 49.47 µM 1.20236490178577 0.115855972185262 no 425 0.114611090706341 532 2679265
SGTC_687 k029-0044 34.9 µM 1.1996495830607 0.116365561193628 no 426 0.115137730612063 651 5829338
SGTC_1308 1187-1617 41.4 µM 1.19916177329003 0.116457277618106 no 427 0.11523252403195 659 2882570
SGTC_1724 st037281 8.293 µM 1.19864525585055 0.116554447445439 no 428 0.115332956516452 634 574124 YDL195W SEC31
SGTC_2161 5662504 8.5105 µM 1.19653832632702 0.11695140911209 no 429 0.11574327574485 596 2859334
SGTC_175 3793-3120 23.7 µM 1.19578392581422 0.117093776639811 no 430 0.115890445124843 571 5322297
SGTC_1618 st003135 44.5 µM 1.19239271912193 0.117735268506612 no 431 0.1165536469152 619 1270615
SGTC_2940 9060638 45.86 µM 1.19099014843849 0.118001309154026 no 432 0.116828726181949 628 4027022
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.19097946692524 0.118003336861656 no 433 0.116830822858663 669 6708561
SGTC_2778 tioconazole 65.09 nM 1.18870246005284 0.118436151531957 no 434 0.117278386114543 653 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_798 1287-0182 476 µM 1.18760686661053 0.118644801865952 no 435 0.117494165643531 695 1649755
SGTC_2299 7976368 114.88 µM 1.18587594061505 0.118974977200619 no 436 0.117835647906834 610 2979718
SGTC_523 1934-0222 13.7 µM 1.18059950452195 0.119985462810986 no 437 0.118880930281869 641 1361595
SGTC_20 0481-0013 4.944 µM 1.17885835027956 0.12032023339396 no 438 0.119227292421898 617 182045
SGTC_1917 st066507 28.5 µM 1.17726492236553 0.120627176858774 no 439 0.119544891489518 668 3156428
SGTC_471 1-acyl-paf 4 µM 1.17384376116456 0.121288059698744 no 440 0.120228806018858 627 16759367
SGTC_2710 st078562 53.7235 µM 1.17131373029389 0.121778433378229 no 441 0.120736347220348 633 17250908
SGTC_384 k007-0144 5.16 µM 1.1638990892382 0.123223565496136 no 442 0.122232454370624 699 6824886
SGTC_124 0136-0217 7.121 µM 1.1625205753142 0.12349356072736 no 443 0.122512035989956 752 3976905
SGTC_507 nimesulide 162 µM 1.15655890726532 0.124665980709753 no 444 0.123726309649659 675 4495 A COX2 inhibitor.
SGTC_2461 5755302 26.15 µM 1.15549232614326 0.124876551987865 no 445 0.123944436651047 686 2788904
SGTC_1552 6-methylflavone 10.6 µM 1.1543573590846 0.125100897230502 no 446 0.124176844708492 597 689013
SGTC_2798 7813637 45.45 µM 1.1542567120959 0.125120805371977 no 447 0.124197468974287 648 956368
SGTC_987 1497-1013 404 µM 1.15163890891872 0.125639388491097 no 448 0.124734742861738 622 1676435
SGTC_1157 4092-0394 27.6 µM 1.15041136344635 0.125883079291097 no 449 0.124987241021044 720 3659885
SGTC_3251 9135047 49.47 µM 1.15001569974336 0.125961696158917 no 450 0.12506870251977 598 17682963
SGTC_482 fipronil 114 µM 1.14969462234967 0.126025518170708 no 451 0.125134835014022 600 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2736 butenafine 14.65 µM 1.14164922533047 0.127632102707799 no 452 0.126799926985906 697 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2183 6420625 130.508 µM 1.14130390279993 0.127701377374941 no 453 0.126871739298546 731 2897619
SGTC_1048 3161-0300 24.5 µM 1.14125039834244 0.127712113166944 no 454 0.126882868469417 678 2165101
SGTC_1836 st055642 81 µM 1.14092417615459 0.12777758396989 no 455 0.126950738874324 661 8571
SGTC_146 3448-8650 53.125 µM 1.1400660431771 0.1279499173976 no 456 0.127129393772414 813 2891488 YIL048W NEO1
SGTC_1231 0242-0792 125 µM 1.13949571799117 0.128064541493337 no 457 0.127248226629415 654 3707635
SGTC_36 0335-0881 14.2 µM 1.13741722665428 0.128482880772568 no 458 0.127681954599752 726 23828853
SGTC_1633 st005664 67.9 µM 1.13594395242563 0.128779981480418 no 459 0.127990010937554 691 2063822
SGTC_2910 7948405 25.97 µM 1.13160117289939 0.129658518791209 no 460 0.128901073386785 617 2971328
SGTC_2174 5790901 200 µM 1.13124587862834 0.129730577512576 no 461 0.128975808366333 658 786020
SGTC_2788 5282734 71.43 µM 1.12994620109282 0.129994406826341 no 462 0.129249447236995 747 743706
SGTC_118 0083-0097 135.343 µM 1.12942680855788 0.130099945219312 no 463 0.12935891450661 888 5207356
SGTC_525 k781-2675 26.7 µM 1.12733247078541 0.130526107459863 no 464 0.129800969323476 699 3651118 YDL195W SEC31
SGTC_557 1315-0110 16.2 µM 1.1136733115731 0.13332918987918 no 465 0.13270968137657 690 6833801
SGTC_3253 9135987 49.47 µM 1.11304328091589 0.133459474122387 no 466 0.132844920784957 623 4182430
SGTC_2480 5767542 37.17 µM 1.11208739787459 0.133657308647671 no 467 0.133050287292076 715 2867358
SGTC_2775 cyproheptadine 69.59 µM 1.11187120912199 0.133702080140517 no 468 0.133096764607921 705 2913 A selective serotonin reuptake inhibitor.
SGTC_2928 9011484 9.79 µM 1.10737408752735 0.134635747562611 no 469 0.134066112216065 647 2994751
SGTC_1867 st057372 64 µM 1.10624674129775 0.134870500726291 no 470 0.134309868407992 679 688837
SGTC_1832 st054113 55 µM 1.10587101387168 0.134948802753194 no 471 0.134391176236018 673 1251267
SGTC_1040 k898-0338 155 µM 1.10446476268232 0.135242143838676 no 472 0.134695790468986 768 20969351
SGTC_1145 3546-0597 10.2 µM 1.10288065956116 0.135573107680915 no 473 0.135039497085655 723 875334
SGTC_417 st075190 100 µM 1.10175768930888 0.135808063708554 no 474 0.135283514638796 727 222757
SGTC_1875 nocodazole 6 µM 1.10041601218034 0.136089144604269 no 475 0.135575452523234 707 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1037 k284-1091 78.7 µM 1.09844561716158 0.13650266305218 no 476 0.136004976154881 651 3334711
SGTC_1163 k060-0048 49.9 µM 1.09811141999446 0.136572884746989 no 477 0.136077919624698 744 6809982
SGTC_342 k048-0088 23.3 µM 1.09660564810537 0.136889584759262 no 478 0.136406908698135 687 6820570
SGTC_755 1995-0008 37.3 µM 1.09530534890357 0.137163472497514 no 479 0.136691442462393 738 689533
SGTC_293 4049-0273 38.5 µM 1.09339951767716 0.137565582128771 no 480 0.137109212613809 668 1380311
SGTC_22 0964-0034 14.468 µM 1.0931822836456 0.137611467178575 no 481 0.137156886997748 736 138402
SGTC_116 0155-0182 31.788 µM 1.09159379817473 0.137947310967041 no 482 0.137505841650301 833 771486
SGTC_2137 5261020 140 µM 1.08835405837254 0.138634001137512 no 483 0.138219417162254 701 763655
SGTC_594 1487-1584 10.8 µM 1.08688239240816 0.138946701034913 no 484 0.138544394395514 705 5013332
SGTC_1522 st012842 45.6 µM 1.08531908088622 0.139279399432782 no 485 0.138890178878981 652 3491067 YOR116C RPO31
SGTC_3270 9137563 49.47 µM 1.08430284482888 0.139495961652598 no 486 0.139115272183477 664 17015724
SGTC_1047 2043-3044 82 µM 1.08430171599018 0.139496202337971 no 487 0.139115522355914 739 669592
SGTC_2608 thymoquinone 42.66 µM 1.08421756387947 0.139514145627867 no 488 0.139134172949747 670 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.0804205896527 0.140325387036183 no 489 0.139977465599272 736 442882
SGTC_451 chloral hydrate 100 µM 1.08018396194328 0.140376049484371 no 490 0.140030134387344 781 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1822 st052468 42 µM 1.07830217723954 0.140779385326822 no 491 0.140449462880296 691 2873678
SGTC_1670 st016595 4.04 µM 1.07792437886957 0.140860456134623 no 492 0.140533752438123 736 597879
SGTC_793 0488-0545 106 µM 1.07782954087236 0.140880812155749 no 493 0.140554916874421 735 292548
SGTC_1800 st050079 29.0735 µM 1.07710915661968 0.141035500532381 no 494 0.140715751412939 844 3645560
SGTC_2580 diallyl disulphide 81.36 µM 1.07660632693281 0.141143541575216 no 495 0.140828088233923 676 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3176 9106582 49.47 µM 1.07642314026148 0.141182916120078 no 496 0.140869028954301 566 17018027
SGTC_1630 st005209 31.3 µM 1.07557551758181 0.141365202947323 no 497 0.141058570791543 814 3367314
SGTC_1460 k062-0059 9.15 µM 1.07316218463668 0.141885079421197 no 498 0.141599177112343 720 1373085
SGTC_575 k072-0246 11.9 µM 1.07151365002889 0.142240947494837 no 499 0.141969268228458 757 6796779
SGTC_1493 4348-0038 111 µM 1.07033792159515 0.142495119886935 no 500 0.142233615492797 789 800424
SGTC_1803 st050068 52.4 µM 1.06907135039709 0.142769274439145 no 501 0.14251876001767 887 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_818 4072-2707 53.5 µM 1.06767179493209 0.143072628411486 no 502 0.142834292777074 707 882871
SGTC_1189 1431-2119 7.28 µM 1.0639755849212 0.14387587525652 no 503 0.143669879990645 760 3107275
SGTC_2856 9022925 19.48 µM 1.06271857038577 0.144149736940884 no 504 0.143954798367924 736 4944862
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.05992632030814 0.144759332215338 no 505 0.144589060210817 721 803109
SGTC_2348 9022543 33.42 µM 1.05919499873795 0.144919278532096 no 506 0.144755491132982 758 3162678 YDL140C RPO21
SGTC_2924 9010168 62.78 µM 1.05787217355399 0.145208893927211 no 507 0.145056861456244 739 2993929
SGTC_1847 st056231 15 µM 1.05554715654809 0.145718869443019 no 508 0.145587577153249 796 5393180
SGTC_2258 7960471 200 µM 1.05441611565366 0.1459673898113 no 509 0.145846223579594 638 2974708
SGTC_348 k064-0012 10.7 µM 1.05189436911635 0.146522510750921 no 510 0.146424007826788 713 5066323
SGTC_227 fluconazole 33.516 µM 1.05086484507405 0.146749550324968 no 511 0.14666033420589 792 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1500 4488-1866 171 µM 1.04933951591137 0.147086362842301 no 512 0.147010942522101 803 2900003
SGTC_878 0828-0289 13.7 µM 1.04412194627046 0.148242386361794 no 513 0.148214486682672 771 745350 YLR208W SEC13
SGTC_479 n-linoleoylglycine 10 µM 1.04009894992799 0.149137875361918 no 514 0.149146965741797 717 6433346 An anti-infammatory.
SGTC_3040 9091894 49.47 µM 1.03823314733122 0.14955441292796 no 515 0.149580762023266 691 25236966
SGTC_1383 3049-0032 20.7 µM 1.03719445264451 0.149786636014174 no 516 0.149822621431544 775 712864
SGTC_3269 9137823 49.47 µM 1.0349233780845 0.150295222271277 no 517 0.150352347921916 687 17682936
SGTC_2996 9066192 71.4286 µM 1.03376005938509 0.150556181982883 no 518 0.150624173940021 742 6472854
SGTC_492 tmb-8 126 µM 1.03261645988209 0.150813012214754 no 519 0.150891711109074 608 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3118 9124250 49.47 µM 1.0313552327806 0.151096597345863 no 520 0.151187133005992 696 1504786
SGTC_3280 9140961 49.47 µM 1.03095612366187 0.151186410323027 no 521 0.151280697905779 735 4901226
SGTC_2346 9031566 143.75 µM 1.03001988797268 0.151397234194069 no 522 0.15150033485523 780 4771086
SGTC_1401 3807-4679 7.6 µM 1.02908197799306 0.15160863101728 no 523 0.15172057706209 746 3291456
SGTC_2466 5983409 37.09 µM 1.02866989810441 0.151701572282633 no 524 0.151817409869299 746 2879657
SGTC_2946 9065502 71.43 µM 1.0281639927115 0.15181572689692 no 525 0.151936346453106 613 16489101
SGTC_1700 st030840 7.9285 µM 1.02756085459839 0.151951896077594 no 526 0.152078222972912 808 5499307
SGTC_869 0564-0080 44.1 µM 1.02616706567995 0.15226687905898 no 527 0.152406421218556 767 6843321
SGTC_2061 5245884 80.95 µM 1.02258129150718 0.153079220532355 no 528 0.153252929463732 782 573863
SGTC_1212 0520-0165 585 µM 1.02188068003761 0.153238275852268 no 529 0.153418688783488 752 5403258
SGTC_142 0335-0849 62.6745 µM 1.02183528554214 0.153248585249107 no 530 0.153429432869349 884 3889043 YPR107C YTH1
SGTC_1938 st074717 56.4 µM 1.0209251311997 0.153455384436022 no 531 0.153644955710525 715 17250979
SGTC_247 mechlorethamine 29.705 µM 1.01637876755968 0.154491145326243 no 532 0.154724526252434 738 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1246 0422-0085 105 µM 1.01394066095664 0.155048498492184 no 533 0.155305533880711 815 264295
SGTC_3252 9135871 49.47 µM 1.01306171636868 0.155249751142629 no 534 0.155515341496134 775 17682838
SGTC_462 ag-879 158 µM 1.01145569291738 0.155617928797187 no 535 0.155899188529873 820 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_141 0443-0274 32.331 µM 1.01059267787971 0.155816010954408 no 536 0.156105710878339 887 1627241
SGTC_159 3970-0959 50 µM 1.0101415874477 0.155919612895825 no 537 0.156213730017885 978 6615653
SGTC_3069 9117009 49.47 µM 1.00960779212449 0.156042268316601 no 538 0.15634161745738 665 41904981
SGTC_2837 9008476 45.46 µM 1.00882300478585 0.15622271208805 no 539 0.15652976310456 791 2992805
SGTC_2199 6590217 200 µM 1.0084520056821 0.156308062620965 no 540 0.15661875864893 722 703109
SGTC_2965 9082772 38.63 µM 1.00805772332752 0.156398803264023 no 541 0.156713375900207 824 16459634
SGTC_1602 st001878 87.6 µM 1.00702137198953 0.156637475881065 no 542 0.156962251952876 798 595405 YLR310C CDC25
SGTC_2072 5231554 129 µM 1.00529303653461 0.157036046112696 no 543 0.157377883584893 851 789545
SGTC_121 0557-0495 61.343 µM 1.00349823003507 0.157450650635833 no 544 0.157810265244406 994 3104427
SGTC_1478 0453-0656 35.7 µM 1.00067187929629 0.158105001458177 no 545 0.158492733426768 819 5258496
SGTC_1190 1486-1332 13 µM 0.998006071103102 0.158723817261522 no 546 0.15913820735881 804 4150046
SGTC_1379 2144-0755 36.5 µM 0.994774563869219 0.159476075319709 no 547 0.159922960010328 860 5392327
SGTC_2057 5236571 38.335 µM 0.994708610833859 0.159491452698054 no 548 0.159939002630754 830 54684039 YBR257W POP4
SGTC_3297 9117502 71.43 µM 0.994426311810424 0.159557283516198 no 549 0.160007681812719 827 7453720
SGTC_1243 0416-0003 5.65 µM 0.993209850053043 0.159841160140485 no 550 0.160303849558396 768 2141977
SGTC_1539 benzyladenosine 56 µM 0.991994883046263 0.16012501752063 no 551 0.160600010769254 781 92208 A nucleotide analog.
SGTC_783 0848-0141 92.7 µM 0.991374384981712 0.160270113912595 no 552 0.160751401595346 770 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_794 k038-0031 316 µM 0.988541543650849 0.16093363291262 no 553 0.161443749488706 883 6624242
SGTC_1609 st001574 46.4 µM 0.988446285261316 0.160955975816123 no 554 0.161467064430798 818 3960012
SGTC_2362 9071156 126 µM 0.987297023349736 0.16122569533703 no 555 0.161748524746173 808 653133
SGTC_1693 xanthone 101.9 µM 0.987226428331785 0.161242272842018 no 556 0.161765824256285 841 7020 An insecticide.
SGTC_1259 0671-0132 43 µM 0.986113952749323 0.161503657212403 no 557 0.162038598770443 792 X1259
SGTC_2260 7964312 200 µM 0.984423891819373 0.161901277894597 no 558 0.16245356780387 766 231951
SGTC_3139 9095020 49.47 µM 0.98362500288501 0.16208945431906 no 559 0.162649963472087 653 25236292
SGTC_2384 9036245 200 µM 0.983265716943523 0.162174129700262 no 560 0.16273833922507 841 6462766
SGTC_1885 st057546 99.9 µM 0.98319468815354 0.162190872951523 no 561 0.162755814306341 855 702008
SGTC_120 rhodamine 6G 52.259 µM 0.982112607322023 0.162446085477891 no 562 0.163022187559262 966 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_177 1327-0068 8.361 µM 0.980716663180848 0.162775709595134 no 563 0.163366242167516 827 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2150 5556613 200 µM 0.980714570902079 0.162776203970917 no 564 0.163366758199619 855 743190
SGTC_2888 9058547 12.99 µM 0.979320379414039 0.163105848756833 no 565 0.163710851996497 714 16476514
SGTC_2032 5185112 25.99 µM 0.978912695004712 0.163202324218182 no 566 0.163811559492744 766 5718189
SGTC_2020 4017018 200 µM 0.977412015045434 0.163557768285028 no 567 0.164182608540073 805 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1093 fluphenazine 7.97 µM 0.976990466569813 0.163657704663195 no 568 0.164286936052844 842 6602611 An atypical antipsychotic.
SGTC_906 1165-0455 526 µM 0.976129587700739 0.163861916093433 no 569 0.164500125358569 806 3252859
SGTC_2208 7283366 200 µM 0.975758166189621 0.163950073047443 no 570 0.164592160070298 842 898663
SGTC_2958 9077254 16.72 µM 0.975418966627911 0.164030608996549 no 571 0.164676239635297 780 16457351
SGTC_2052 5265182 7.135 µM 0.974512000759882 0.164246075394958 no 572 0.164901191722911 833 1239884
SGTC_13 0199-0087 65 µM 0.974484805915168 0.164252538862605 no 573 0.164907939852176 860 4589825
SGTC_416 estradiol valerate 100 µM 0.97301872269949 0.164601230692788 no 574 0.165271998457206 815 13791 A steroid.
SGTC_1118 chelidonine 707.474 nM 0.972922516409634 0.164624129064021 no 575 0.165295906628417 890 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1846 st056244 14.8 µM 0.972131154596059 0.164812561973136 no 576 0.16549265242416 847 5393182
SGTC_2211 7117706 200 µM 0.970896946579674 0.165106720706234 no 577 0.165799799420693 795 822771
SGTC_617 3770-0098 35 µM 0.970519279922508 0.16519680091171 no 578 0.165893859742056 793 5962639
SGTC_2643 anethole 100 µM 0.967079294628702 0.166018762550663 no 579 0.166752197674237 872 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1666 st014829 29 µM 0.966432220656568 0.166173671381582 no 580 0.166913973848109 867 3858230
SGTC_879 0831-1030 162 µM 0.965043030563634 0.166506557328846 no 581 0.167261629703777 854 1549252
SGTC_2041 5107442 45.335 µM 0.964823768033925 0.166559137620511 no 582 0.167316544510286 842 793005
SGTC_521 r062-0005 13.8 µM 0.96292884846141 0.167013995640831 no 583 0.167791615555657 811 2832033
SGTC_1667 st014849 34.6 µM 0.962464586994197 0.167125559396057 no 584 0.167908141842002 863 5348460
SGTC_1222 0366-0074 1.18 µM 0.960688239510516 0.167552865800657 no 585 0.168354473104461 896 286520
SGTC_2851 9015922 71.43 µM 0.959420892524128 0.167858160211304 no 586 0.168673377093943 826 2996893
SGTC_582 0987-0078 156 µM 0.958335926696838 0.168119804704832 no 587 0.168946696563871 952 1625765
SGTC_1041 0206-0046 107 µM 0.9580487124006 0.16818911165702 no 588 0.16901909783236 836 50494
SGTC_754 3474-0146 171 µM 0.958023463792995 0.16819520521324 no 589 0.169025463479533 776 24762078
SGTC_2887 9044784 58.44 µM 0.956008990031706 0.168681840589465 no 590 0.169533846277394 954 6465546
SGTC_2046 4110841 106 µM 0.954918667750894 0.168945606234304 no 591 0.169809414298949 867 44119630 YMR134W ERG29
SGTC_1637 st007924 17.4 µM 0.954231597917017 0.169111954948709 no 592 0.169983211752387 821 683336
SGTC_1970 st070122 35.8 µM 0.954191583665431 0.16912164616952 no 593 0.169993337052639 823 102928
SGTC_1123 mangostin 811.285 nM 0.951434366847647 0.169790287013818 no 594 0.170691960716652 818 5281650 An antioxidant.
SGTC_1474 0330-0125 5.35 µM 0.95036048464375 0.170051167673887 no 595 0.170964557602226 869 X1474
SGTC_2194 5927483 104.545 µM 0.949250641073889 0.170321054323635 no 596 0.171246575493871 918 760979
SGTC_2045 5106652 78.05 µM 0.948838188606472 0.170421422510024 no 597 0.171351457900328 869 673349
SGTC_1082 camptothecin 424.86 nM 0.946902603749319 0.17089294299863 no 598 0.171844205521578 756 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2107 5363541 170.161 µM 0.946143727489446 0.171078037540526 no 599 0.172037641606303 891 244052
SGTC_1456 k015-0012 13 µM 0.944752897720271 0.17141760210851 no 600 0.172392522068511 930 2989616
SGTC_3009 9080819 71.4286 µM 0.944663194995207 0.171439517386187 no 601 0.172415426398351 860 17027216
SGTC_1249 0481-0015 10.2 µM 0.940471675382659 0.172465544152599 no 602 0.173487835961 815 4227577
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.93788904431187 0.173099682848212 no 603 0.174150716978313 852 641818 YHR062C RPP1
SGTC_2536 dehydroabietamide 32.04 µM 0.937359071407308 0.173229995709835 no 604 0.17428694333781 906 3983547
SGTC_1361 1608-0041 5.61 µM 0.936685129032754 0.173395798839635 no 605 0.174460273957283 866 X1361
SGTC_745 0469-0705 296 µM 0.935684833023911 0.173642077583957 no 606 0.174717740954648 962 3486736
SGTC_2104 5389443 200 µM 0.934719084484278 0.173880061592466 no 607 0.174966544497241 894 2244536
SGTC_3291 9121177 71.43 µM 0.933819969768523 0.174101811758572 no 608 0.175198383300797 768 17015612
SGTC_60 0986-0278 202 µM 0.933631575446299 0.174148298534686 no 609 0.175246985888882 755 3110598
SGTC_151 3013-0144 2.285 µM 0.931949615978578 0.174563675867169 no 610 0.175681282200297 873 906558 YHR107C CDC12
SGTC_1449 4112-4002 201 µM 0.931395855207572 0.174700570393272 no 611 0.175824417050481 817 2059539
SGTC_261 5-fluorouridine 15.376 µM 0.931265579836675 0.174732785509565 no 612 0.175858101067816 874 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1194 1488-0194 225 µM 0.92873764011847 0.175358652989918 no 613 0.176512534480756 890 1391452
SGTC_327 1273-0057 3.96 µM 0.928462580396278 0.175426837928193 no 614 0.176583834787507 847 3108138
SGTC_3167 9103034 49.47 µM 0.927841331642416 0.175580901986482 no 615 0.176744940380868 833 5127859
SGTC_1725 st036284 20.55 µM 0.927438974876757 0.175680728551563 no 616 0.176849331281265 955 707914
SGTC_395 anisomycin 6.25 µM 0.925518201695688 0.176157776665383 no 617 0.177348210111048 822 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_459 nigericin 15.3 µM 0.925362791283615 0.176196410612369 no 618 0.177388613386121 926 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.924572127025143 0.176393047279762 no 619 0.177594258613816 944 16486 A toxic proline analog.
SGTC_1448 4255-0083 152 µM 0.924295657888688 0.176461837365571 no 620 0.177666201434625 927 5399660
SGTC_555 4296-0685 37 µM 0.921966476845187 0.177042049610703 no 621 0.178273030988589 918 2908540 YHR072W ERG7
SGTC_2477 5967686 25.23 µM 0.916646548070871 0.178371788484792 no 622 0.179663942042926 867 776118
SGTC_39 0986-0283 58.349 µM 0.913409188846405 0.179184051837128 no 623 0.180513687309325 958 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1081 sertraline 6 µM 0.913352834050535 0.179198211999359 no 624 0.180528501660371 933 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2785 7756463 72.73 µM 0.91310181209889 0.179261294356616 no 625 0.18059449869338 909 2201551
SGTC_1075 aripiprazole 15.2 µM 0.91211187179274 0.179510204600383 no 626 0.18085491472674 943 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2815 7968870 71.43 µM 0.91166725331571 0.179622069977896 no 627 0.180971953671159 892 2977326 YHR190W ERG9
SGTC_3183 9108214 49.47 µM 0.905657400122092 0.181138436179768 no 628 0.182558608491962 831 4974831
SGTC_1337 1486-1011 40.3 µM 0.90422900460779 0.181500015494235 no 629 0.182936991687523 946 X1337
SGTC_2866 9034245 58.44 µM 0.904145141517489 0.181521258351193 no 630 0.182959222292165 907 6462273
SGTC_971 1315-0384 26.7 µM 0.900236877950725 0.182512962855365 no 631 0.183997102336816 886 6769120
SGTC_2891 9063876 19.48 µM 0.898982989459797 0.182831847165059 no 632 0.18433086068825 873 6472478
SGTC_1759 st043059 70 µM 0.898635569738577 0.182920263161258 no 633 0.18442340300567 912 669426
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.897960599325054 0.183092114881936 no 634 0.184603277723569 965 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2446 5162541 200 µM 0.896058300058717 0.183576993976986 no 635 0.185110813414104 873 1549321
SGTC_1574 spiramycin 23.7 µM 0.894670173556821 0.183931319570602 no 636 0.185481713668063 939 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_344 k064-0035 6.43 µM 0.893396519032816 0.184256800049931 no 637 0.185822433068593 883 5088750
SGTC_2197 6588183 93.1375 µM 0.889289433787836 0.18530879872712 no 638 0.186923774326432 905 884136
SGTC_1955 wogonin 32.4 µM 0.889044619938696 0.185371623486687 no 639 0.18698955003423 917 5281703 A flavanone.
SGTC_2789 5281112 71.43 µM 0.887500408540092 0.18576820767773 no 640 0.187404773170487 895 765948
SGTC_1862 st057513 3.81 µM 0.887339488590524 0.185809565378573 no 641 0.187448075715853 937 5393163
SGTC_618 k072-0232 33.2 µM 0.883947425823521 0.186682680891045 no 642 0.188362297046247 901 5872756 YGL099W LSG1
SGTC_797 k781-0471 270 µM 0.883807059137789 0.18671886585918 no 643 0.188400187536321 955 23738129
SGTC_152 4469-0003 551.229 µM 0.881454000408151 0.18732610449256 no 644 0.18903607044317 939 697280
SGTC_2383 9036125 200 µM 0.880406302210919 0.187596869559158 no 645 0.18931962182123 908 79580
SGTC_2662 daunorubicin 22.37 µM 0.878288471346053 0.188144935591256 no 646 0.189893595292537 899 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_499 genistein 192 µM 0.87647499328252 0.188615023716977 no 647 0.19038593254079 943 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1876 myriocin 605 nM 0.874519656163567 0.189122694933135 no 648 0.190917660255419 967 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_438 sphingosine 6.67 µM 0.874031772874566 0.1892494968865 no 649 0.19105047545263 883 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1739 st037196 92.5 µM 0.87345515985674 0.189399427363678 no 650 0.191207518350495 987 612214
SGTC_2173 5763948 167 µM 0.873333412904037 0.189431093258394 no 651 0.191240686743662 967 2867177
SGTC_390 dec-rvkr-cmk 16.7 µM 0.872736361611554 0.189586431071941 no 652 0.191403396753048 973 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1471 k673-0312 37 µM 0.870983790099438 0.190042858802897 no 653 0.191881501987497 961 24099884
SGTC_1705 st027868 56.3335 µM 0.869212628977239 0.190504813396819 no 654 0.192365420533735 984 292948
SGTC_3131 9127911 49.47 µM 0.86919038867519 0.19051061849648 no 655 0.19237150179358 895 45595681
SGTC_2090 5301565 104.445 µM 0.868846400145422 0.190600419223596 no 656 0.192465575002157 975 2056344
SGTC_359 0081-0058 15.9 µM 0.867877797811982 0.190853419525937 no 657 0.192730617247259 870 3494159
SGTC_3013 9080133 71.4286 µM 0.867630755802918 0.190917980211034 no 658 0.192798251944425 999 17050193
SGTC_1465 k213-0056 144 µM 0.867453596520279 0.190964286352172 no 659 0.192846763206688 897 24048857 YMR208W ERG12
SGTC_2388 9080168 200 µM 0.861226889391737 0.192596205336752 no 660 0.194556546567123 883 15943073
SGTC_2088 5278280 127.392 µM 0.859989680425257 0.192921469911123 no 661 0.194897365527532 975 791502
SGTC_1937 st074714 47.2 µM 0.858356178932761 0.19335143410123 no 662 0.195347908527021 984 17250970
SGTC_233 rapamycin 362 pM 0.8575801954337 0.193555890291666 no 663 0.195562157338675 1026 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_923 1900-2434 73.3 µM 0.857032988471916 0.193700147671792 no 664 0.195713326767951 926 5910570
SGTC_941 3237-0776 460 µM 0.856990297251347 0.19371140489651 no 665 0.19572512347325 931 760008
SGTC_2661 dactinomycin 12.96 µM 0.85538768668486 0.194134284906001 no 666 0.196168279018298 999 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1706 st031321 9.9705 µM 0.853880763107121 0.194532428584329 no 667 0.196585529658937 999 6103185
SGTC_271 rotenone 740 µM 0.852396481245059 0.194925075523522 no 668 0.196997036245898 1013 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3091 9116372 49.47 µM 0.85108441773814 0.195272565374965 no 669 0.197361230329938 922 17169793
SGTC_1662 st014054 52 µM 0.847896554173494 0.196118413177416 no 670 0.198247791875569 974 2838777
SGTC_194 1486-1323 56.904 µM 0.847870530737472 0.196125327204411 no 671 0.198255039007055 979 5178754
SGTC_1764 st044502 93.5 µM 0.846978473905018 0.196362422370729 no 672 0.198503559959572 967 8407
SGTC_1514 1189-1591 158 µM 0.846544594497009 0.196477803705989 no 673 0.198624503708236 985 767698 YMR146C TIF34
SGTC_2818 7996756 12.99 µM 0.846192416997885 0.19657148829489 no 674 0.198722705744295 934 2241621
SGTC_3071 9117417 49.47 µM 0.845530700755167 0.196747588096972 no 675 0.19890729948255 900 45595590 YGL055W OLE1
SGTC_2184 6075246 200 µM 0.842764844270569 0.197484687736705 no 676 0.199679986651713 953 2267320
SGTC_3213 9129884 49.47 µM 0.842621939136106 0.197522817206043 no 677 0.199719958539635 929 17190742
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.842517427688489 0.197550705418063 no 678 0.199749194405627 1003 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1003 4049-0218 100 µM 0.841212161536049 0.197899207829318 no 679 0.20011454430657 983 295161
SGTC_2779 methotrexate 400 µM 0.837507394456171 0.19889039136568 no 680 0.201153711139291 1076 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.8363840221515 0.199191531676885 no 681 0.201469449159065 1003 2333 A French combination drug.
SGTC_1991 st073000 8.92 µM 0.835914649491449 0.19931743683229 no 682 0.201601460210938 1020 4301969 YIL048W NEO1
SGTC_2802 7925815 54.55 µM 0.834571664672969 0.199677945515116 no 683 0.201979460806289 964 1262923
SGTC_197 4544-0043 41.561 µM 0.834277208199991 0.199757041345076 no 684 0.202062396089895 1044 896523
SGTC_407 eburnamonine 100 µM 0.833811818570984 0.199882091048225 no 685 0.20219351718751 943 3195
SGTC_3056 9094900 49.47 µM 0.833427604907331 0.199985364323847 no 686 0.202301805731343 979 25236784
SGTC_1130 3454-2858 15.9 µM 0.83335341593227 0.200005309366978 no 687 0.202322719487888 921 715628 YIL048W NEO1
SGTC_69 0096-0274 206.684 µM 0.832242939039592 0.200303994062184 no 688 0.202635915704394 1081 6741392
SGTC_2713 st079149 53.4 µM 0.831042104968602 0.200627283519724 no 689 0.202974921925839 994 3103253
SGTC_139 0099-0334 718.624 µM 0.829493626004997 0.201044628328133 no 690 0.203412571042512 1100 97690
SGTC_1841 st054148 70 µM 0.827067330658392 0.201699607754194 no 691 0.204099449898324 920 675442
SGTC_2205 7238770 200 µM 0.826822718709864 0.201765711694728 no 692 0.204168775585261 1017 279867
SGTC_1961 st076550 68.7 µM 0.826816842817417 0.201767299755634 no 693 0.204170441049566 931 1579337
SGTC_2552 juarezic acid 87.02 µM 0.825975827693219 0.201994675744167 no 694 0.204408902019626 1142 1549512
SGTC_49 0717-0965 32.132 µM 0.825799313437979 0.202042417422682 no 695 0.204458971816331 1102 5889349 YGL099W LSG1
SGTC_299 1273-0059 1.44 µM 0.825718838016305 0.20206418579081 no 696 0.20448180178888 978 2848077
SGTC_286 k060-0067 22.9 µM 0.824261033061947 0.202458760754842 no 697 0.204895627281314 970 5985051
SGTC_1757 st041620 31.8375 µM 0.823138645890626 0.202762863932213 no 698 0.205214577117211 1019 5289815
SGTC_393 acivicin 6.25 µM 0.820977856406118 0.203349083076887 no 699 0.205829440717811 930 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2330 7979373 200 µM 0.820415799772073 0.203501733831613 no 700 0.205989555738748 986 1863007
SGTC_3332 9141069 11.198 µM 0.819957259799999 0.203626320780132 no 701 0.206120236310261 974 17332883
SGTC_1235 benzylparaben 21.5 µM 0.81986899391768 0.203650308154956 no 702 0.206145397088127 959 7180
SGTC_945 3381-0768 11.3 µM 0.818005323481257 0.204157177542548 no 703 0.206677073767635 1058 1126236 YIL048W NEO1
SGTC_3033 9090887 49.47 µM 0.817048694974498 0.204417646928512 no 704 0.206950300338154 1045 19325384
SGTC_787 4152-0075 138 µM 0.817026765457004 0.204423620183184 no 705 0.206956566222285 996 9566539
SGTC_77 0828-0286 12.516 µM 0.815699384297558 0.204785371309801 no 706 0.207336045630223 1040 745345
SGTC_680 0417-1641 114 µM 0.814732354337776 0.205049155500912 no 707 0.207612764608981 964 2835990
SGTC_1575 cyproterone acetate 48 µM 0.813391385131287 0.205415275984783 no 708 0.207996848501016 996 9880 An androgen receptor antagonist and liver toxin.
SGTC_910 3454-3003 490 µM 0.812196551201127 0.205741824470173 no 709 0.20833942908557 1017 820824
SGTC_1010 4112-3296 15.2 µM 0.811785933009464 0.205854117636928 no 710 0.208457237580815 1063 704384
SGTC_26 0302-0163 425.158 µM 0.811313197998475 0.205983443122197 no 711 0.208592916352099 1050 3100915
SGTC_747 3448-8087 38.7 µM 0.808427596873836 0.206773897385001 no 712 0.209422235314227 1024 5168703
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.807529264074392 0.207020344248562 no 713 0.209680810752814 990 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1834 st055981 52.8 µM 0.80661081707778 0.207272488792673 no 714 0.209945369841987 1048 471719 YDL150W RPC53
SGTC_2630 antimycin a 100 µM 0.806489813593179 0.207305721846576 no 715 0.209980239571531 1088 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1073 triclabendazole 3.09 µM 0.806412635151616 0.20732692019831 no 716 0.21000248195962 1053 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2192 5915882 198.485 µM 0.806246119968149 0.207372660748101 no 717 0.210050475404237 992 2876149
SGTC_189 3970-0742 2.116 µM 0.806235956517579 0.207375452769665 no 718 0.210053404949376 1046 2891807
SGTC_1912 st060209 90.8 µM 0.80482624462511 0.207762932788565 no 719 0.210459977297631 994 688787
SGTC_2708 st078559 56 µM 0.80198072326562 0.208546367701119 no 720 0.211282054534359 940 17250902
SGTC_440 fluspirilene 35.1 µM 0.799940803348155 0.209109073105697 no 721 0.211872547759444 1038 3396 An atypical antipsychotic.
SGTC_2985 9022375 71.43 µM 0.798224943105276 0.209583079213812 no 722 0.212369982581214 1090 4939335
SGTC_444 curcumin 90.4 µM 0.796365322391721 0.210097512071105 no 723 0.212909863977225 999 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2773 thioridazine 9.09 µM 0.794143191390927 0.210713199084955 no 724 0.21355603786865 1099 5452 An antipsychotic.
SGTC_862 0452-0056 10.2 µM 0.79281888662974 0.211080627711234 no 725 0.213941675539574 1019 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1280 0880-0253 10.1 µM 0.79233652780021 0.211214551510707 no 726 0.21408223913866 1029 6836607
SGTC_198 3454-2873 16.191 µM 0.791358073588382 0.211486365849142 no 727 0.214367534320378 1058 710957
SGTC_2803 7707263 71.43 µM 0.790458781137643 0.211736369617719 no 728 0.214629942616327 1009 2199229
SGTC_2908 7930301 100 µM 0.790450181608653 0.211738761125785 no 729 0.214632452809613 1058 2223178
SGTC_1402 3909-7673 35.9 µM 0.790044975140181 0.211851465977248 no 730 0.21475075148603 1042 5328014
SGTC_3287 9117173 37.0625 µM 0.789659134712488 0.211958816938341 no 731 0.214863431516605 1037 2789709
SGTC_1403 3909-7815 62.9 µM 0.787827054444362 0.212468983924863 no 732 0.215398936897438 1031 6615483
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.787038662661762 0.212688742629385 no 733 0.215629616871414 1085 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1557 sumaresinolic acid 42.3 µM 0.786912470932384 0.212723930010578 no 734 0.215666553311771 1011 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2701 st077767 14.721 µM 0.786020192792409 0.212972830372405 no 735 0.215927828629527 1078 5721188
SGTC_2902 5787006 60.46 µM 0.784618952976619 0.213364048022389 no 736 0.216338507152579 1021 591003
SGTC_1687 st020778 55.3625 µM 0.783457085579664 0.213688751820953 no 737 0.216679372475549 1119 4259299
SGTC_825 1988-2224 89.6 µM 0.780834732567702 0.214422670512003 no 738 0.217449851579199 1036 1180859
SGTC_1038 k292-0204 154 µM 0.778255741057476 0.2151458811846 no 739 0.218209130871644 1036 4454212
SGTC_467 ro 31-8220 72.8 µM 0.777379712543068 0.215391862265973 no 740 0.218467389078753 1059 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3084 9116877 49.47 µM 0.775042544693668 0.216048916149345 no 741 0.21915726011269 1014 27241325
SGTC_2628 lathosterol 100 µM 0.774889378660904 0.21609201660045 no 742 0.219202514420235 1128 6710616
SGTC_3317 9138495 8.753 µM 0.774195111178909 0.216287443773402 no 743 0.219407709456071 1104 17020139
SGTC_187 1488-2104 32.728 µM 0.772797841844109 0.216681066755381 no 744 0.219821015427811 1122 2852859
SGTC_664 1222-0054 14.9 µM 0.772628114790596 0.216728908553931 no 745 0.219871250346287 1097 6813991
SGTC_1027 k015-0025 8.67 µM 0.772349138419245 0.216807558265333 no 746 0.219953834615259 1110 3598955
SGTC_1604 st002052 72.4 µM 0.772081627113473 0.216882991213861 no 747 0.220033041640459 1114 6254834 YHR062C RPP1
SGTC_3179 9107801 49.47 µM 0.76981447284845 0.217522893187471 no 748 0.220704976653001 1105 4818259
SGTC_653 0203-0016 55.2 µM 0.769163629562551 0.217706794165877 no 749 0.220898089292807 1090 295302
SGTC_1014 4130-3005 69.3 µM 0.768281352854032 0.217956231670543 no 750 0.221160025254946 1112 743608
SGTC_2253 7938677 135.83 µM 0.767948913545908 0.218050261726512 no 751 0.221258768040897 1083 2301972
SGTC_908 3448-7491 47.7 µM 0.767264232139594 0.218243996695132 no 752 0.221462214966544 1126 1203031
SGTC_2848 9016370 25.97 µM 0.764682428650933 0.218975425967118 no 753 0.222230335942021 1105 7894410
SGTC_2172 5754775 163.918 µM 0.764514161793998 0.219023145141271 no 754 0.222280450289458 1030 2263357
SGTC_1664 st014217 9.02 µM 0.764481600310821 0.219032380015662 no 755 0.222290148710121 1168 3982782
SGTC_1338 1486-1223 76 µM 0.76340822840735 0.219336928052925 no 756 0.222609987093046 1101 3444526
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.760792555060679 0.220080091780589 no 757 0.223390490949581 1095 6708514
SGTC_946 3434-1334 87.4 µM 0.759769601251856 0.220371125319979 no 758 0.22369615829427 1062 4047976
SGTC_2791 5663188 71.43 µM 0.759768463722889 0.220371449073257 no 759 0.223696498329964 1059 54690634
SGTC_3320 9137005 35.139 µM 0.759675031020984 0.220398041980591 no 760 0.223724428691139 1038 4908713
SGTC_609 0986-0026 86.3 µM 0.758525677397961 0.220725322588731 no 761 0.22406817357515 1078 2848610
SGTC_615 k087-0205 167 µM 0.758171431139874 0.220826250965341 no 762 0.224174180828043 1087 9642773
SGTC_2909 7941780 10.49 µM 0.756929911988415 0.221180180971479 no 763 0.224545926878216 1115 1243215
SGTC_2894 9048625 32.47 µM 0.756784843473805 0.221221558003014 no 764 0.22458938731681 1131 4092861
SGTC_2401 5128683 200 µM 0.755067737610705 0.221711654186647 no 765 0.225104169903946 1080 708373
SGTC_24 0417-1663 219 µM 0.752886672793106 0.222335066991146 no 766 0.225759008674332 1094 4329390
SGTC_2131 toluylene red 5.2905 µM 0.752743909462188 0.222375907812123 no 767 0.225801909208006 1074 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1771 st048882 4.1505 µM 0.751868331564252 0.222626481124983 no 768 0.226065122138585 1109 4580403
SGTC_2607 solasodine 47.35 µM 0.750398716188624 0.223047417963443 no 769 0.22650730196151 1113 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2766 oltipraz 83.91 µM 0.749083303226459 0.223424571239411 no 770 0.226903498968279 1080 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_835 0312-0010 67.2 µM 0.748872189704921 0.223485135169771 no 771 0.226967121879143 1087 1626196
SGTC_2323 6148992 148.28 µM 0.748567616534862 0.223572527117458 no 772 0.227058928284698 1043 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_289 k017-0060 526 µM 0.747384097184263 0.223912301749618 no 773 0.227415870989803 1121 5512909
SGTC_846 0335-0850 148 µM 0.747368928704923 0.223916658347143 no 774 0.227420447767486 1106 6819598
SGTC_2560 caryophyllene 100 µM 0.7462475927234 0.224238854955535 no 775 0.227758931572747 1188 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_931 2812-0076 566 µM 0.746037341510557 0.224299296318033 no 776 0.227822429054189 1160 3450959
SGTC_1626 st003712 1.76 µM 0.744725496538155 0.224676623995218 no 777 0.228218841225363 1071 24207035
SGTC_2370 9071495 200 µM 0.744183106331788 0.224832737534013 no 778 0.228382853461925 1064 21791103
SGTC_2813 7971799 71.43 µM 0.743391450435376 0.225060706357878 no 779 0.22862235947434 1097 2234054
SGTC_2284 7945075 39.21 µM 0.743107271027622 0.225142571885795 no 780 0.228708368945102 1202 1245402
SGTC_859 0439-0102 54.6 µM 0.742230172327166 0.22539535013553 no 781 0.22897394534734 1157 610143
SGTC_2640 pentamidine 10.38 µM 0.738517123909449 0.226467222050509 no 782 0.230100132642911 1151 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.738308639933939 0.226527491813453 no 783 0.230163458697928 1162 4174840
SGTC_1762 st045503 25.4615 µM 0.738201802256218 0.22655838058102 no 784 0.230195913932199 1168 4645554
SGTC_1164 k060-0068 93.7 µM 0.736717600004231 0.226987737045231 no 785 0.230647050778631 1170 5963676
SGTC_2440 5628896 157.78 µM 0.736590515913463 0.227024521796497 no 786 0.230685702096243 1123 5522048
SGTC_2335 9018011 154.17 µM 0.735778999239104 0.227259496213894 no 787 0.230932601847751 1168 6458208
SGTC_1516 st013856 110 µM 0.735468423539996 0.227349459567086 no 788 0.231027131920279 1080 5281404 A mutagen and neurotoxin.
SGTC_1351 1496-0003 46.5 µM 0.735435093589461 0.227359115326814 no 789 0.231037277856271 1154 3891978
SGTC_1787 fluconazole 80 µM 0.735230817641708 0.227418299563759 no 790 0.231099466720563 1080 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3271 9137798 49.47 µM 0.735159177092905 0.227439057813151 no 791 0.231121278864201 1073 6498326
SGTC_940 3232-1287 54.8 µM 0.734723664324123 0.227565273034666 no 792 0.231253902609041 1121 1585493 YIL048W NEO1
SGTC_2667 digitoxin 100 µM 0.730681092575937 0.228738724379232 no 793 0.232486983496899 1109 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1838 st055369 84.5 µM 0.729774045811552 0.229002481862881 no 794 0.232764155789446 1141 676036
SGTC_517 1365-0151 113 µM 0.728928709191532 0.2292484483786 no 795 0.23302263613331 1157 768657
SGTC_2678 equilin 100 µM 0.72871070646444 0.229311904371859 no 796 0.233089321127631 1166 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_269 exalamide 29 µM 0.726852645543723 0.229853146146243 no 797 0.233658114383894 1096 3316 A derivative of salicylamide.
SGTC_2588 indole-3-carbinol 100 µM 0.723520130287664 0.230825676775631 no 798 0.234680195593239 1144 3712 Induces cell cycle arrest.
SGTC_2265 7929201 200 µM 0.723434948444856 0.230850565545596 no 799 0.234706353196141 1169 1265108
SGTC_3293 9120939 62.045 µM 0.722321718477338 0.231175971246593 no 800 0.23504835152446 1148 934087
SGTC_2543 pimpinellin 60.67 µM 0.720537192997246 0.231698135362643 no 801 0.235597154223652 1094 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2459 5811157 9.22 µM 0.719626487218736 0.231964867048143 no 802 0.235877499620075 1142 2870684 YBR192W RIM2
SGTC_1444 4112-3581 28 µM 0.716115923738288 0.232994655235778 no 803 0.236959886032308 1180 2877249
SGTC_3324 9138759 60.749 µM 0.714639469125391 0.233428515505725 no 804 0.237415924771023 1172 45595710
SGTC_3028 9087778 49.47 µM 0.712139827563632 0.234164062706824 no 805 0.238189096798476 1142 17217395
SGTC_337 1315-0038 354 µM 0.710854050111319 0.234542916222659 no 806 0.238587341371416 1148 1626437
SGTC_2617 dihydrotanshinone i 20.83 µM 0.710381806491842 0.234682147593005 no 807 0.238733701107591 1205 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1545 lovastatin 49.4 µM 0.710353194407213 0.23469058474896 no 808 0.238742570263612 1223 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_959 1222-0044 107 µM 0.7101479677376 0.234751107080326 no 809 0.238806191581156 1166 6083612
SGTC_3129 9127257 49.47 µM 0.708804047324302 0.235147648856527 no 810 0.239223042908812 1096 837894
SGTC_2389 9091542 195.52 µM 0.708568359336802 0.235217229872152 no 811 0.239296188528298 1145 3626624 YOL127W RPL25
SGTC_1523 st012844 44.7 µM 0.705776398927691 0.236042351183694 no 812 0.240163600645776 1182 4274103
SGTC_2336 9001819 198.65 µM 0.701863777312497 0.237201345484989 no 813 0.241382060230925 1225 2989602
SGTC_2555 cholic acid 100 µM 0.701796894623506 0.237221184571337 no 814 0.241402917838025 1170 6708657 Influences liver metabolism.
SGTC_2793 7325131 81.82 µM 0.701750803342064 0.237234856934177 no 815 0.241417292139732 1161 4176441
SGTC_2730 imipramine 71.33 µM 0.701748960241079 0.237235403674459 no 816 0.241417866949857 1204 3696 A tricyclic antidepressant.
SGTC_751 0833-0568 350 µM 0.70167222079082 0.23725816839614 no 817 0.241441800434544 1210 6954252
SGTC_614 0462-0418 107 µM 0.701644720954862 0.237266326501496 no 818 0.241450377391654 1082 5188303
SGTC_1052 3253-3998 198 µM 0.701270221603505 0.237377440868004 no 819 0.241567196919018 1182 5450317
SGTC_641 4092-0595 30 µM 0.700630501106407 0.237567312708566 no 820 0.241766819225041 1195 786260
SGTC_998 3996-0085 177 µM 0.700616747114506 0.237571395868548 no 821 0.241771112087875 1220 715391
SGTC_3065 9113888 49.47 µM 0.700226295274634 0.23768732572259 no 822 0.241892996230408 1232 16648368
SGTC_1447 4239-0816 81.9 µM 0.699765515314633 0.237824176758515 no 823 0.242036876997089 1166 1341554
SGTC_2003 4023581 200 µM 0.697782607882459 0.238413590443862 no 824 0.242656578698256 1199 16641307
SGTC_554 4483-2211 187 µM 0.697127742551261 0.238608422890835 no 825 0.24286142689685 1171 747107
SGTC_2685 mycophenolic acid 18.85 µM 0.696641093670758 0.238753264791965 no 826 0.243013715952077 1166 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3041 9091929 49.47 µM 0.694765607580283 0.239311917644551 no 827 0.243601102412328 1264 25236887
SGTC_2980 9014342 25.29 µM 0.691003823171948 0.240434593344854 no 828 0.244781569228714 1209 2996599
SGTC_1119 parthenolide 318.541 nM 0.690123532120086 0.240697723019001 no 829 0.245058252920555 1275 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1186 1319-0216 26 µM 0.688748486151287 0.241109054365261 no 830 0.245490779102794 1254 4565136
SGTC_691 1548-0686 185 µM 0.688492110265503 0.241185788912741 no 831 0.245571468499829 1179 46495133
SGTC_2176 5809774 33.9695 µM 0.688421655051712 0.241206878825325 no 832 0.245593645423404 1201 2870539
SGTC_1098 clofazimine 15.1 µM 0.688397663855364 0.241214060527347 no 833 0.245601197287866 1234 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1399 3562-5772 25 µM 0.688178456887302 0.241279684943085 no 834 0.245670204262552 1154 23847490
SGTC_3100 9120536 49.47 µM 0.688173429570591 0.241281190094449 no 835 0.245671786998222 1108 16421196
SGTC_2055 5235184 200 µM 0.686537148296264 0.241771354826596 no 836 0.246187223538064 1206 2836034
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.685767054144724 0.24200223126158 no 837 0.246430007470972 1266 94937 An inhibitor of serotonin biosynthesis.
SGTC_322 k048-0136 19.3 µM 0.685500935260093 0.242082042258217 no 838 0.246513935331072 1214 6823282
SGTC_3156 9099931 49.47 µM 0.685309321426716 0.242139517483023 no 839 0.24657437546983 1227 18111053
SGTC_1503 4585-0012 61.3 µM 0.683597055535423 0.242653445785666 no 840 0.24711482225274 1217 2922052
SGTC_225 nsc-122657 1.016 µM 0.682510550002517 0.242979861166861 no 841 0.247458087026285 1157 275685
SGTC_2400 5203494 178.7 µM 0.68210804107622 0.243100845904348 no 842 0.247585318206654 1196 6777674
SGTC_2232 chlorophetanol 41.5365 µM 0.681879515102886 0.243169549944415 no 843 0.247657569742322 1278 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3348 9149464 3.537 µM 0.680022892758296 0.243728113721938 no 844 0.248244982825069 1227 1951442
SGTC_1228 0124-0032 52.5 µM 0.679939897611702 0.243753098927871 no 845 0.24827125883227 1254 X1228
SGTC_1529 apigenin 74 µM 0.679557312435304 0.243868291843783 no 846 0.248392403289191 1276 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2105 5350118 200 µM 0.6790420560472 0.244023477267581 no 847 0.248555607468072 1238 2133313
SGTC_648 0375-0473 33.3 µM 0.676840935570742 0.244687012305102 no 848 0.249253441179784 1227 1713139
SGTC_2441 5730946 39.09 µM 0.676805890503444 0.244697584607617 no 849 0.249264560135464 1237 1774275
SGTC_2151 5563267 85.4165 µM 0.676092878818971 0.244912737471044 no 850 0.249490838824824 1232 5310824
SGTC_1196 1588-0294 184 µM 0.675749557018754 0.245016371886938 no 851 0.249599833051887 1211 6144269
SGTC_1168 k815-0004 80.5 µM 0.675225713199381 0.245174543758613 no 852 0.249766186257613 1216 642433
SGTC_572 0960-0087 17.7 µM 0.674955154449724 0.245256259040639 no 853 0.249852128647096 1219 6796365
SGTC_1782 st039423 80.636 µM 0.672963001841435 0.245858387840812 no 854 0.250485414562224 1208 2068169
SGTC_2679 rapamycin 1 nM 0.666439663447443 0.247835609498068 no 855 0.252565058759306 1234 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2831 7999036 19.48 µM 0.66556611426331 0.248101024924112 no 856 0.252844235751155 1250 2988270
SGTC_3263 9137018 49.47 µM 0.66495246265024 0.248287564819714 no 857 0.253040449350673 1195 43844957
SGTC_1984 st072354 53.1 µM 0.664588251779146 0.248398314225082 no 858 0.253156942756131 1190 5762938
SGTC_2113 5491891 107.031 µM 0.664333286143744 0.248475859955255 no 859 0.253238510687066 1251 789979
SGTC_1286 0929-0070 131 µM 0.664044191251346 0.24856380142581 no 860 0.253331013874823 1299 1420408
SGTC_96 0929-0093 37.281 µM 0.663852388169372 0.248622156278886 no 861 0.253392395899294 1222 6991579
SGTC_1248 0469-0687 58.6 µM 0.662633192284211 0.248993259336384 no 862 0.25378275330432 1253 4017482
SGTC_1054 3429-0080 167 µM 0.662478588871864 0.249040339106769 no 863 0.253832276171205 1264 1162877
SGTC_2602 kawain 100 µM 0.661167622076218 0.249439744482058 no 864 0.254252411416069 1235 5369129
SGTC_922 1866-0035 480 µM 0.658897306494639 0.250132234083371 no 865 0.254980857812487 1239 3156169
SGTC_1723 st034307 2.5525 µM 0.658191205159002 0.250347816185563 no 866 0.255207637713642 1280 867466
SGTC_3045 9092950 49.47 µM 0.658115770917718 0.250370853081902 no 867 0.255231871305407 1291 44120432
SGTC_972 1319-0219 195 µM 0.656133405804919 0.250976651003845 no 868 0.25586914608245 1227 23903702
SGTC_911 3456-4043 236 µM 0.655307945136125 0.251229134983492 no 869 0.256134753213322 1327 914281
SGTC_2745 rifampicin 24.3 µM 0.654273138583751 0.251545841305353 no 870 0.256467924221676 1189 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3134 9127454 49.47 µM 0.65417632110126 0.25157548343656 no 871 0.256499107563933 1338 24262820
SGTC_2252 omeprazole 400 µM 0.653975958394887 0.251636833358999 no 872 0.256563647417871 1214 4594 A proton pump inhibitor.
SGTC_2157 5649910 96.377 µM 0.653704609645921 0.251719931400792 no 873 0.256651066430659 1229 2858091
SGTC_92 0063-0024 660.874 µM 0.653576999140549 0.251759015945864 no 874 0.256692183404038 1295 3594437
SGTC_528 3492-0019 172 µM 0.653306963373849 0.251841733063059 no 875 0.256779202072278 1302 2869262
SGTC_364 0083-0097 67.7 µM 0.648603408203832 0.253284820207639 no 876 0.258297376001926 1308 5207356
SGTC_2914 7968218 45.32 µM 0.648372605350194 0.253355744041799 no 877 0.258371992155284 1238 2977111
SGTC_2311 7694451 200 µM 0.648367144000198 0.253357422396525 no 878 0.258373757887982 1251 2163142
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.647722879587371 0.25355545551229 no 879 0.258582101669037 1247 75037 A free radical scavenger.
SGTC_2369 9071472 200 µM 0.646732258380984 0.253860109879006 no 880 0.258902620781403 1305 17296037
SGTC_573 3702-0553 84.7 µM 0.646201344227231 0.254023465579211 no 881 0.25907448455285 1251 1222756
SGTC_2709 st078560 56 µM 0.64583638694104 0.254135790387071 no 882 0.259192660146343 1296 17250903
SGTC_386 1509-0011 3.07 µM 0.645382519864836 0.254275515759066 no 883 0.259339664183508 1303 3107280
SGTC_1977 st070720 65.3 µM 0.645295191656726 0.254302404827822 no 884 0.259367954055907 1271 682188
SGTC_889 0919-1524 82.7 µM 0.644244243029975 0.254626117373666 no 885 0.259708532655594 1256 3905452
SGTC_223 busulfan 5 mM 0.644172091249666 0.254648349434891 no 886 0.259731923188068 1286 2478 A DNA alkylator.
SGTC_1801 st050089 28.441 µM 0.643772444562458 0.25477151060649 no 887 0.259861502377647 1291 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_612 0302-0167 22.4 µM 0.642332309728158 0.255215582886998 no 888 0.260328720051148 1312 235821
SGTC_1588 farnesol 29.9 µM 0.642191645121615 0.255258979158986 no 889 0.260374378543536 1303 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1661 st013063 9.66 µM 0.641527365925852 0.25546396726544 no 890 0.260590053443302 1315 721395
SGTC_3355 9151058 44.0485 µM 0.641281046305034 0.255540000220488 no 891 0.260670050652714 1276 17015728
SGTC_1175 0741-0056 27.6 µM 0.640066296288401 0.255915137225759 no 892 0.261064749728451 1333 765927
SGTC_2704 st078022 71.1 µM 0.639455513752498 0.256103866549869 no 893 0.261263322458367 1307 54697681
SGTC_2863 9028737 58.44 µM 0.6385172961644 0.25639391330556 no 894 0.261568499332769 1288 6460917
SGTC_415 dibenzyl ketone 100 µM 0.638349506876767 0.256445802827629 no 895 0.261623095943916 1319 7593
SGTC_1786 berberine 21.6 µM 0.636798441905946 0.256925734951234 no 896 0.262128070565045 1251 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_667 1498-1044 59 µM 0.636442925740465 0.257035804927461 no 897 0.26224388500293 1319 6739982
SGTC_2539 epi(13)torulosol 80 µM 0.63606307574229 0.257153435904539 no 898 0.262367655491988 1264 6708597
SGTC_253 dyclonine 31.25 µM 0.634703115054168 0.25757481445296 no 899 0.262811030820667 1353 3180 An oral anasthetic.
SGTC_2768 sulfasalazine 50.2 µM 0.633633065944751 0.257906616920587 no 900 0.263160158143598 1370 5384001 An antioxidant and salicylic acid derivative.
SGTC_633 0437-0093 97.7 µM 0.633049057730226 0.258087800582652 no 901 0.263350803714921 1297 2831118
SGTC_1376 2910-0861 41.3 µM 0.63074853726493 0.258802159391452 no 902 0.264102478643577 1335 1112859
SGTC_1215 3852-0577 11.2 µM 0.630732701708824 0.258807080200034 no 903 0.264107656558239 1375 2884876
SGTC_613 3914-0030 117 µM 0.630138250007429 0.258991837686796 no 904 0.264302067948803 1115 1145395
SGTC_2906 7926292 26.41 µM 0.629861175655619 0.259077976582035 no 905 0.264392708122589 1274 2966319
SGTC_3226 9131256 49.47 µM 0.62846130179178 0.259513405960056 no 906 0.264850894894352 1201 17178073
SGTC_43 0570-0105 72.5 µM 0.625368351828968 0.260476803191456 no 907 0.265864664271744 1341 1114046 YDL195W SEC31
SGTC_3062 9077494 49.47 µM 0.624032779058568 0.260893378251426 no 908 0.266303029116951 1306 16459633
SGTC_2123 5259487 200 µM 0.623966903526947 0.260913934182543 no 909 0.26632466040187 1286 2173474
SGTC_1155 4088-0394 48.2 µM 0.623411127576504 0.261087392761491 no 910 0.266507193718106 1264 2326248
SGTC_1378 2093-0007 380 nM 0.620347641294673 0.262044574575106 no 911 0.267514467864933 1331 3618014
SGTC_1036 k216-0215 33.5 µM 0.618425041916993 0.262646205284295 no 912 0.268147597403648 1299 622330
SGTC_2328 6201408 200 µM 0.616649616939564 0.263202408357294 no 913 0.268732930046612 1291 2890418
SGTC_2596 sinensetin 100 µM 0.616448065595522 0.263265588136598 no 914 0.268799419237205 1306 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1695 st026914 34.495 µM 0.615792321438421 0.263471196145363 no 915 0.26901579793816 1291 3289191
SGTC_2558 carylophyllene oxide 100 µM 0.613721099462412 0.264121163849603 no 916 0.269699821584528 1368 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1531 st059297 52.4 µM 0.613005048394662 0.264346056842016 no 917 0.269936500825619 1336 7566702
SGTC_490 phenamil 164 µM 0.61285842552626 0.264392119288217 no 918 0.26998497749208 1292 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1051 3253-3903 78 µM 0.612237999329656 0.264587075077985 no 919 0.270190151914049 1282 5509239
SGTC_375 3970-0961 9.27 µM 0.612053658290719 0.264645014433748 no 920 0.270251128363959 1312 2898222
SGTC_1492 4158-0558 28.5 µM 0.610749561811385 0.26505508302621 no 921 0.270682694679593 1369 3967268
SGTC_2488 5268135 45.7 µM 0.608950758284862 0.265621239728925 no 922 0.271278539216333 1366 1270356 YLR208W SEC13
SGTC_3042 9091578 49.47 µM 0.608631562862526 0.265721767554901 no 923 0.271384339335942 1291 25236497
SGTC_1472 k841-0093 193 µM 0.608565866187691 0.265742460545358 no 924 0.271406117625504 1374 X1472
SGTC_1892 st058411 7.36 µM 0.607349099238835 0.266125862676892 no 925 0.271809630282704 1360 3934738
SGTC_711 k292-0785 179 µM 0.606268248987716 0.266466672342918 no 926 0.272168319503197 1324 4146315
SGTC_1004 4084-0029 199 µM 0.605542029801698 0.266695785005307 no 927 0.272409453507229 1346 716894 YLR208W SEC13
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.603614891336598 0.267304254361281 no 928 0.273049855012874 1355 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2576 guaiol 23.12 µM 0.603223644798049 0.267427870941175 no 929 0.273179960030321 1327 227829
SGTC_1117 retinoic acid 1.10837 µM 0.60308647106767 0.267471218591071 no 930 0.273225583016928 1379 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1104 tacrolimus 29.8 µM 0.601418255548692 0.267998667245156 no 931 0.273780721288639 1359 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3260 9137109 49.47 µM 0.601048832382175 0.268115540537143 no 932 0.27390373100606 1250 17478346
SGTC_1809 st050081 57.6 µM 0.600603783570683 0.268256373345786 no 933 0.274051958660889 1387 5036894
SGTC_2606 farnesol 9.78 µM 0.600397927955522 0.268321527605686 no 934 0.274120534196855 1391 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2004 4023728 41.89 µM 0.599389983388823 0.268640661610047 no 935 0.274456427484907 1315 360084 YDR527W RBA50
SGTC_405 ebelactone b 50 µM 0.598854552613333 0.268810266494269 no 936 0.274634940109346 1330 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1295 1013-0063 9.78 µM 0.597803756092382 0.269143276660198 no 937 0.274985442068387 1357 6826038
SGTC_893 0958-0369 48.9 µM 0.597679853548197 0.269182556517483 no 938 0.275026785317926 1396 6819948
SGTC_1794 st048918 76.9 µM 0.59673735881824 0.269481442382057 no 939 0.275341372960826 1301 672303
SGTC_2858 9025781 8.96 µM 0.595949163394997 0.269731524187269 no 940 0.275604594193047 1357 4894980 YPL153C RAD53
SGTC_2835 9006588 71.43 µM 0.589625018099569 0.271742272479835 no 941 0.277721037538905 1358 2345538
SGTC_2953 9074162 66.49 µM 0.588599573911932 0.27206901177664 no 942 0.278064959901245 1377 16451992
SGTC_1653 st012112 65 µM 0.588356657339837 0.272146441369188 no 943 0.278146461796821 1378 720429
SGTC_435 c-PAF 6.7 µM 0.58796587943892 0.272271024701048 no 944 0.278277597671121 1323 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2520 obtusaquinone 4.71 µM 0.58745417586633 0.272434203008198 no 945 0.278449358919026 1429 5967872
SGTC_1793 st048256 72.231 µM 0.585370246113255 0.273099253337994 no 946 0.279149395366873 1299 672022
SGTC_584 0986-0246 15.4 µM 0.584816022865435 0.273276259506029 no 947 0.279335714700737 1433 53315 YDR232W HEM1
SGTC_3240 9133527 49.47 µM 0.584729500395386 0.273303897921902 no 948 0.279364807364114 1323 17617455
SGTC_791 1348-1292 225 µM 0.582965069273268 0.273867823042406 no 949 0.279958407643366 1369 5437054
SGTC_726 3448-4391 34.2 µM 0.581715373290754 0.274267582767566 no 950 0.280379207341413 1466 1356692
SGTC_3353 9151644 39.2805 µM 0.578473692986501 0.275305890765242 no 951 0.28147217667357 1360 4909158
SGTC_2086 5274770 176.623 µM 0.577668123104509 0.275564214043505 no 952 0.281744102250961 1374 689278
SGTC_218 alverine citrate 93.75 µM 0.577353232408093 0.275665222899728 no 953 0.28185043015522 1397 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1735 st034310 56.75 µM 0.576779284342015 0.275849377524159 no 954 0.282044282670489 1461 871153
SGTC_1183 1254-0324 198 µM 0.575621781227982 0.276220952999305 no 955 0.282435427687524 1426 5799357
SGTC_305 1682-2595 20.8 µM 0.575599042621881 0.276228254884635 no 956 0.282443114160156 1380 226033
SGTC_1426 4048-4480 71.7 µM 0.574785767651887 0.276489478299292 no 957 0.282718096689428 1413 14224343
SGTC_1636 st007707 68.9 µM 0.574001367813929 0.276741541737066 no 958 0.282983437838232 1426 403051
SGTC_3313 9133968 57.047 µM 0.573784157323635 0.27681136127177 no 959 0.283056935375475 1352 1494643
SGTC_1521 st012942 49.4 µM 0.572050516625924 0.27736892694956 no 960 0.283643875710617 1500 24207259
SGTC_3152 9099253 49.47 µM 0.571662593220084 0.277493764261889 no 961 0.283775290600306 1378 25236131
SGTC_1292 0kpi-0043 232 µM 0.571037059680326 0.277695124520773 no 962 0.283987260883854 1348 3333905
SGTC_855 0428-0020 25 µM 0.570619115930163 0.277829701049669 no 963 0.284128928837314 1371 6812414
SGTC_644 1498-1197 63.3 µM 0.570274659314483 0.277940638890097 no 964 0.284245712686815 1447 6741615
SGTC_2204 7233102 200 µM 0.570190221945831 0.277967836613279 no 965 0.284274343657087 1354 2172480
SGTC_272 doxorubicin 8.13 µM 0.56935563987327 0.278236729752547 no 966 0.284557407350801 1368 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3338 9144300 39.5675 µM 0.566711810287198 0.279089378786397 no 967 0.285454997768221 1395 4901274
SGTC_1200 1643-0193 18.4 µM 0.565162093140947 0.279589760697271 no 968 0.285981758691237 1375 5403974
SGTC_1969 st069479 40.1 µM 0.561130449096725 0.28089355853663 no 969 0.287354306033379 1453 3895485
SGTC_1452 4194-0072 190 µM 0.560845710698067 0.280985751402158 no 970 0.287451361099644 1497 1343545
SGTC_2472 5377652 49.4 µM 0.558671895408371 0.28169007288497 no 971 0.288192831671538 1370 1610903
SGTC_1092 toremifene 6.32 µM 0.558269613057668 0.281820506626354 no 972 0.288330145754397 1390 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3024 9090631 49.47 µM 0.557292323655567 0.28213749857279 no 973 0.288663859794292 1369 25236383
SGTC_484 loperamide 105 µM 0.557013274010875 0.282228042139391 no 974 0.288759179974987 1377 3955 An opioid-receptor agonist.
SGTC_560 2332-1943 155 µM 0.556902856800554 0.282263873202714 no 975 0.288796901328316 1403 21177716
SGTC_2286 7945697 125 µM 0.555912367035097 0.282585391074735 no 976 0.289135381751498 1344 1245733
SGTC_1663 st014140 55.4 µM 0.554894315334101 0.282916039043263 no 977 0.289483475203475 1473 4207120
SGTC_1734 st037168 69.4 µM 0.553445715300825 0.283386842664819 no 978 0.289979121260856 1402 708907
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.552127792059024 0.283815501608976 no 979 0.290430400947018 1368 6708760
SGTC_607 4491-0986 66.8 µM 0.551260800107454 0.284097662812686 no 980 0.290727453135007 1481 698981 YDR232W HEM1
SGTC_3006 9075424 71.4286 µM 0.549146288641535 0.284786389434598 no 981 0.29145253056286 1361 7465181
SGTC_864 0469-0573 172 µM 0.547971741065146 0.285169300271795 no 982 0.291855653367339 1362 689425
SGTC_2801 7907800 81.82 µM 0.547694159266013 0.285259829739898 no 983 0.291950961643993 1419 6620925
SGTC_3018 9082602 49.47 µM 0.5471770256338 0.285428522235631 no 984 0.292128559172145 1401 17332089
SGTC_646 4092-0839 27.3 µM 0.544924140442532 0.286163982362577 no 985 0.292902846229315 1495 877796
SGTC_1681 tripelennamine 100 µM 0.544076162546696 0.286441039895015 no 986 0.29319453162443 1389 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_160 3453-0671 289.699 µM 0.543699829824802 0.28656403884042 no 987 0.29332402478132 1342 5322268
SGTC_281 1672-3440 14.9 µM 0.541947386335212 0.287137129546276 no 988 0.29392737571957 1442 6833000
SGTC_409 arachidonic acid 100 µM 0.541241917637056 0.287367987677339 no 989 0.294170424331057 1433 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_803 4488-1585 147 µM 0.540446489590903 0.287628389443035 no 990 0.294444577130854 1406 747204
SGTC_2269 7935389 174.42 µM 0.539089343485905 0.288072939904838 no 991 0.294912604152231 1392 97605
SGTC_1172 0370-0043 85 µM 0.537160083350878 0.288705451122552 no 992 0.295578520535292 1471 376585
SGTC_1715 st032160 10.2275 µM 0.537053694492275 0.288740349909297 no 993 0.295615262531821 1442 5289825
SGTC_799 1310-0557 151 µM 0.5353903929934 0.289286221584969 no 994 0.296189965945548 1445 5354492
SGTC_1699 st031318 29.054 µM 0.53528361883282 0.289321279892265 no 995 0.296226876021198 1480 5340658
SGTC_1334 1486-0610 236 µM 0.534103376576352 0.289708934454007 no 996 0.2966350068801 1457 3742339
SGTC_211 3455-0679 143.504 µM 0.533926028493278 0.289767206091261 no 997 0.296696356562056 1430 748649
SGTC_453 enantio-paf c16 10 µM 0.53365265122118 0.289857041014271 no 998 0.29679093681628 1411 13871343 A lipid and platelet activating factor
SGTC_3151 9099821 49.47 µM 0.532509590433938 0.29023280540093 no 999 0.297186550635603 1396 17174189
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.532315928586786 0.290296491478178 no 1000 0.297253600955094 1422 521171
SGTC_1032 k061-1018 98.7 µM 0.530171322763909 0.291002186460273 no 1001 0.29799657601934 1589 4005393
SGTC_3277 9138724 49.47 µM 0.529843340370536 0.291110181589986 no 1002 0.298110276486109 1412 15943418
SGTC_1934 st074720 32.6 µM 0.528869260075448 0.291431028393232 no 1003 0.298448073826419 1398 17250992
SGTC_817 1391-0715 46 µM 0.525591997835904 0.292511716636283 no 1004 0.299585858913456 1418 1353946
SGTC_1547 harmine 94.2 µM 0.522928958844153 0.293391231915876 no 1005 0.300511845691239 1453 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_67 0335-0847 266 µM 0.521955534635911 0.29371302782633 no 1006 0.30085064518019 1689 4552207 YOR254C SEC63
SGTC_866 0495-0101 262 µM 0.520521925918864 0.294187249361377 no 1007 0.301349924960288 1394 635694
SGTC_1366 1683-0113 21.9 µM 0.520043987951237 0.294345424420793 no 1008 0.301516458250633 1444 708623
SGTC_44 0929-0055 61.211 µM 0.519647759221827 0.294476587320041 no 1009 0.30165455206106 1397 1379590
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.519644525488413 0.294477657888096 no 1010 0.301655679200253 1479 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3265 9137266 49.47 µM 0.519518059188601 0.29451952755358 no 1011 0.301699761351843 1504 17224265
SGTC_1550 gossypolone 36.6 µM 0.519452648009666 0.294541184552341 no 1012 0.301722562756138 1436 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_448 monastrol 171 µM 0.51103197061185 0.297335302835259 no 1013 0.304664335147938 1488 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3014 9081533 49.47 µM 0.507113763507444 0.298639543105828 no 1014 0.306037499165286 1578 21367265
SGTC_304 1310-0298 97 µM 0.504670340440175 0.299454191698706 no 1015 0.306895198085567 1414 1550234
SGTC_2860 9025725 38.96 µM 0.504592275678166 0.299480235453872 no 1016 0.306922618117876 1420 40546248
SGTC_1109 tnp00067 928.257 nM 0.504571050784962 0.299487316622984 no 1017 0.306930073489828 1453 676295
SGTC_2342 7990637 118.86 µM 0.504396154897294 0.29954566926912 no 1018 0.306991509766278 1514 2033102 YER133W GLC7
SGTC_564 3555-0129 330 µM 0.504013929333974 0.299673213774046 no 1019 0.307125794310677 1430 563260
SGTC_3266 9136860 49.47 µM 0.503920078728498 0.299704534459841 no 1020 0.307158770122264 1418 4871271 YPR165W RHO1
SGTC_2669 eugenol 100 µM 0.502723467383382 0.300104008491586 no 1021 0.307579354020911 1505 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_531 3788-1495 174 µM 0.498132108371057 0.301639007229908 no 1022 0.309195465406305 1476 2896655
SGTC_161 4065-0411 162.148 µM 0.498036842506955 0.301670894201479 no 1023 0.309229037290829 1539 1906281 YLR208W SEC13
SGTC_994 3910-0338 138 µM 0.495941801381362 0.302372520020316 no 1024 0.309967736340865 1575 3479481
SGTC_2969 9091408 28.7 µM 0.495125515919465 0.302646090683006 no 1025 0.310255761768594 1422 4286311
SGTC_2716 st080858 38.6235 µM 0.494970857251767 0.302697935625922 no 1026 0.310310346033751 1490 5296050
SGTC_1957 st077035 62.4 µM 0.49464732257686 0.302806404337746 no 1027 0.310424545855996 1526 705593
SGTC_3166 9102297 49.47 µM 0.493397781222012 0.303225490737273 no 1028 0.310865774903879 1434 25237072
SGTC_600 1495-0418 41.6 µM 0.492471699350564 0.303536258575078 no 1029 0.311192961865465 1499 5377768
SGTC_1487 3970-0795 2.82 µM 0.492264965781965 0.303605652142294 no 1030 0.311266021720268 1532 3765103
SGTC_774 k060-0086 136 µM 0.491843633617104 0.303747101227443 no 1031 0.311414943955279 1551 5911235
SGTC_1365 1672-3266 55.4 µM 0.489913319830202 0.304395519287647 no 1032 0.312097618585009 1546 6415873
SGTC_1284 0929-0043 16 µM 0.488745264811103 0.30478818348431 no 1033 0.312511026632258 1490 1239883
SGTC_2689 tacrolimus 100 µM 0.488499043212301 0.304870984342316 no 1034 0.312598201632799 1506 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1931 st074438 57.1 µM 0.48813553199006 0.304993246317644 no 1035 0.312726922307611 1454 2787313
SGTC_246 cycloheximide 667 µM 0.487405468695374 0.305238858777337 no 1036 0.312985509426669 1443 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2213 7173844 200 µM 0.485691937634271 0.305815680054427 no 1037 0.313592800389306 1476 892728
SGTC_2765 myclobutanil 7.74 µM 0.485283793516162 0.305953143632218 no 1038 0.313737524981241 1493 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3089 9117425 49.47 µM 0.483093962688264 0.306691148509617 no 1039 0.314514510296791 1438 9401657
SGTC_1766 st045414 44.774 µM 0.482754224311509 0.306805715650483 no 1040 0.314635128409865 1508 253960
SGTC_2078 5212016 200 µM 0.48256068235469 0.306870990630691 no 1041 0.314703850911275 1532 1899708
SGTC_619 1652-1634 108 µM 0.482289943702388 0.306962311649369 no 1042 0.31479999503419 1501 5400454
SGTC_95 0471-0001 561.058 µM 0.481791756086246 0.307130383232009 no 1043 0.314976943142056 1413 4015405
SGTC_748 act1.228 77.9 µM 0.479718779986244 0.307830169835264 no 1044 0.315713686125889 1437 4421505 YNR035C ARC35
SGTC_1311 1190-0148 100 µM 0.478116958366249 0.308371385391863 no 1045 0.31628348132406 1615 1961333
SGTC_358 0075-0058 9.45 µM 0.47806486684023 0.308388992821615 no 1046 0.316302018501251 1709 1069125
SGTC_1045 1348-1485 165 µM 0.478040892473811 0.308397096532911 no 1047 0.316310550122285 1493 6810614
SGTC_1195 1502-0147 41.1 µM 0.476224883692785 0.309011207075876 no 1048 0.316957086754352 1480 817940
SGTC_57 miconazole 162.5 nM 0.474852348650269 0.309475704905912 no 1049 0.317446108825272 1444 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1043 0916-0009 19.3 µM 0.474271348403146 0.309672420712183 no 1050 0.317653210149816 1706 3101130
SGTC_725 1497-0963 19 µM 0.473971932071893 0.309773818771539 no 1051 0.317759961341582 1649 3549977
SGTC_188 3229-0966 278.469 µM 0.473523273398684 0.309925785203912 no 1052 0.317919950406732 1632 5722370
SGTC_683 panaxydol 45 µM 0.472833801872272 0.310159381336143 no 1053 0.31816587817984 1571 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_16 erodoxin 22.806 µM 0.472822105325391 0.310163344841417 no 1054 0.318170050916066 1524 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1161 k007-0610 110 µM 0.471179288949051 0.310720250384601 no 1055 0.318756353728532 1569 5843850
SGTC_3302 9125395 16.351 µM 0.470965677876163 0.310792695248994 no 1056 0.318832622515234 1553 17599668
SGTC_522 1273-0010 11.6 µM 0.470138389199314 0.311073334246962 no 1057 0.319128074263681 1561 5705015
SGTC_423 5-fluorouracil 457 µM 0.468079031847905 0.311772401683551 no 1058 0.319864036704262 1441 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2085 5307070 144.047 µM 0.467828493067404 0.311857495695264 no 1059 0.319953621429105 1475 2840351
SGTC_3039 9090270 49.47 µM 0.466589131795217 0.312278585072519 no 1060 0.320396932095306 1590 17173750
SGTC_1900 st060200 72.8 µM 0.46590021822926 0.312512758683528 no 1061 0.320643462471882 1528 688945
SGTC_2824 7998404 51.95 µM 0.465885596356063 0.312517729731559 no 1062 0.320648695823607 1558 837851
SGTC_350 k064-0020 19.8 µM 0.465760136770256 0.312560384056245 no 1063 0.320693600847358 1621 2790705
SGTC_2926 9010726 65.15 µM 0.465148168263189 0.312768479899665 no 1064 0.320912676801592 1482 2994293
SGTC_2344 7990960 76.95 µM 0.462251108421066 0.313754415132977 no 1065 0.321950628126135 1549 140813
SGTC_85 0868-0259 160.055 µM 0.461833157245538 0.313896763474824 no 1066 0.322100485592117 1569 83173
SGTC_2471 5466956 24.79 µM 0.461215822987992 0.314107069586415 no 1067 0.322321885288838 1564 724419
SGTC_2387 9077560 195.08 µM 0.459662816496786 0.314636396300096 no 1068 0.322879131518878 1493 5303272
SGTC_1217 1183-1422 255 µM 0.458718835925203 0.314958328971078 no 1069 0.323218042986238 1629 2849664
SGTC_251 melphalan 456.522 µM 0.456158930843439 0.315832059600649 no 1070 0.324137847851176 1633 460612 A DNA alkylator.
SGTC_463 ikarugamyin 104 µM 0.456104967946856 0.315850488977698 no 1071 0.32415724895571 1590 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_205 1486-1330 71.903 µM 0.455997253486333 0.315887276926403 no 1072 0.324195976612884 1570 4118834
SGTC_380 3970-0968 6 µM 0.454945007318039 0.316246748673167 no 1073 0.324574401203607 1509 2891601
SGTC_2721 ifenprodil 61.44 µM 0.453671847761046 0.316681921833482 no 1074 0.32503251621519 1622 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1988 st071872 53.4 µM 0.453040900288587 0.316897677366911 no 1075 0.325259645199026 1585 16414116
SGTC_2680 butyl paraben 22.24 µM 0.45207116427155 0.317229404687287 no 1076 0.325608858125801 1569 7184 An antifungal and steroid mimetic.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.450831559587953 0.317653662580314 no 1077 0.326055476755902 1576 66535 A nucleotide analog.
SGTC_980 1473-0395 201 µM 0.450204728558816 0.317868288350049 no 1078 0.326281413522878 1513 768876
SGTC_3093 9117344 49.47 µM 0.448441001929122 0.318472513222573 no 1079 0.326917478101858 1552 24824913
SGTC_2978 9011784 42.97 µM 0.448426149350323 0.318477603534925 no 1080 0.326922836626252 1731 2994934
SGTC_702 1488-0190 94 µM 0.448218965294101 0.318548613736863 no 1081 0.326997588364515 1661 949357
SGTC_3349 9149703 23.001 µM 0.445321484956674 0.319542392712649 no 1082 0.328043721752977 1512 4910494
SGTC_1612 st002233 45.4 µM 0.444009598138108 0.319992771311433 no 1083 0.328517822282491 1567 1035021
SGTC_968 1309-0633 340 µM 0.443787220811784 0.320069141106443 no 1084 0.328598214242667 1612 3761976
SGTC_526 4469-0568 170 µM 0.443620112902974 0.320126535053908 no 1085 0.328658630894416 1522 2901964
SGTC_455 paf C-16 10 µM 0.441820338521572 0.320744948085394 no 1086 0.329309609873515 1561 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_750 4073-0104 132 µM 0.441706928629387 0.320783933078705 no 1087 0.329350647629989 1472 22330957
SGTC_1886 st057356 49.9 µM 0.440512090300961 0.321194782400205 no 1088 0.3297831287985 1495 24207747
SGTC_3116 9124943 49.47 µM 0.440312814305976 0.321263325461187 no 1089 0.329855280486072 1476 41905195 YPL160W CDC60
SGTC_1100 amiodarone 5.07 µM 0.440046916199233 0.321354793375557 no 1090 0.32995156384367 1674 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_610 4215-0184 155 µM 0.438562149943505 0.321865746242241 no 1091 0.330489413887073 1596 5605015
SGTC_2186 6124449 200 µM 0.438535147294345 0.321875041791557 no 1092 0.330499198724502 1611 3834182 YLR033W RSC58
SGTC_2921 7974240 10.71 µM 0.438264776470452 0.321968121964721 no 1093 0.330597178260409 1620 2979074 YDR527W RBA50
SGTC_778 3456-2434 196 µM 0.437936299764685 0.322081221195123 no 1094 0.33071623037642 1726 5539063
SGTC_1707 st032323 6.317 µM 0.437275316340394 0.322308857182005 no 1095 0.330955847131524 1571 3132057 YMR211W DML1
SGTC_356 1634-0012 32.5 µM 0.437079093824995 0.322376447060212 no 1096 0.331026994177763 1658 735457
SGTC_1696 st025591 34.7925 µM 0.432255715714673 0.324039726673262 no 1097 0.332777784571492 1582 2787147
SGTC_3058 9093861 49.47 µM 0.432209698084101 0.324055612255461 no 1098 0.332794505706801 1596 17217477
SGTC_2513 baicalein 25.65 µM 0.430298726715743 0.324715574475497 no 1099 0.333489176605708 1495 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_328 k915-0120 63.5 µM 0.428448810109078 0.325354975808253 no 1100 0.334162197431291 1671 6624543
SGTC_2804 7954240 19.48 µM 0.426983299760038 0.325861877081547 no 1101 0.334695745786198 1694 828705
SGTC_2757 clomiphene 4.22 µM 0.42694096868912 0.325876523647255 no 1102 0.334711162226441 1731 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2264 7948757 110.76 µM 0.426529594476374 0.326018873263848 no 1103 0.334860994014859 1536 2971411
SGTC_2994 9053520 71.4286 µM 0.424556527518988 0.326701974443934 no 1104 0.335579994712394 1702 4647384
SGTC_767 0929-0023 86 µM 0.423569307494457 0.327043981086214 no 1105 0.335939971550793 1588 1204563
SGTC_1335 1486-0900 202 µM 0.420688683861789 0.328042756958913 no 1106 0.336991212736816 1581 X1335
SGTC_637 1181-0519 7.26 µM 0.420280698015156 0.328184314340173 no 1107 0.337140204385848 1579 6252091 YGR060W ERG25
SGTC_3061 glucosamine 200 µM 0.420266100698673 0.328189379575929 no 1108 0.33714553562827 1685 91431 and experimental redox chemotherapeutic
SGTC_1169 aniline yellow 25.8 µM 0.41993748723574 0.328303416062156 no 1109 0.337265560727336 1666 6051 A DNA damaging agent.
SGTC_1946 st076057 65.1 µM 0.417389623874279 0.329188125954429 no 1110 0.338196721589658 1541 953009
SGTC_3168 9103419 49.47 µM 0.416246003251305 0.329585543844424 no 1111 0.338615000044473 1616 16649256
SGTC_857 0438-0306 1.35 µM 0.415793773148744 0.32974275079556 no 1112 0.338780457866878 1610 4686136
SGTC_367 0335-0881 7.1 µM 0.415622478902124 0.32980230499003 no 1113 0.338843137568739 1670 23828853
SGTC_663 1486-0733 13.9 µM 0.415237313145184 0.329936232054339 no 1114 0.33898409306928 1608 722445 YPR165W RHO1
SGTC_262 fenpropimorph 62.5 µM 0.414059371111868 0.330345952810772 no 1115 0.339415313306316 1563 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2893 9048488 25.97 µM 0.413941365983474 0.33038700947285 no 1116 0.339458524146684 1535 6467338
SGTC_1697 st025554 27.742 µM 0.412551711385293 0.330870655326777 no 1117 0.339967543253571 1602 1269519
SGTC_3054 9094397 49.47 µM 0.411754758181287 0.331148148939692 no 1118 0.340259592448028 1537 2598354
SGTC_758 0868-0029 16 µM 0.41162195882354 0.331194397781229 no 1119 0.340308267042248 1731 762687
SGTC_2646 retinol 96.75 µM 0.411306966718924 0.331304107554235 no 1120 0.340423730896999 1620 445354 A vitamin A analog and teratogen.
SGTC_2612 dictamnine 15.46 µM 0.410325469148183 0.331646049816066 no 1121 0.340783605623748 1612 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1511 0906-3109 28.5 µM 0.410203514489993 0.331688547198632 no 1122 0.340828331504022 1600 2882180
SGTC_2316 5844804 197.44 µM 0.408918131185151 0.332136594712424 no 1123 0.341299871356028 1740 776813
SGTC_143 4032-1194 15.74 µM 0.408645374039306 0.332231700878028 no 1124 0.341399963582652 1601 1806963
SGTC_42 0133-0086 60.653 µM 0.40773571170498 0.332548964040587 no 1125 0.34173385810705 1523 162923 Model of phenazepam hydroxylation.
SGTC_2829 7992743 58.44 µM 0.406041750473921 0.333140086955359 no 1126 0.342355962016761 1803 16462845
SGTC_2226 7298446 200 µM 0.402685017040957 0.334312673339093 no 1127 0.343589978779591 1699 3283010
SGTC_1677 st019204 53.9 µM 0.399846500294268 0.335305498145779 no 1128 0.344634789483104 1559 3945625
SGTC_15 0266-0086 27.098 µM 0.399044854344419 0.335586097760875 no 1129 0.344930077164133 1694 1712902 YIL048W NEO1
SGTC_1489 4065-0444 182 µM 0.395386832679142 0.336867674835571 no 1130 0.346278712551044 1738 2877968
SGTC_2955 9076254 12.21 µM 0.394977141439812 0.337011327305999 no 1131 0.3464298788972 1744 16459619
SGTC_1434 4073-0095 163 µM 0.393419768896853 0.33755761488659 no 1132 0.347004735477056 1654 24133745
SGTC_1233 0325-0408 14.2 µM 0.392371458838846 0.33792552895005 no 1133 0.347391885635611 1701 12874
SGTC_1331 1472-0049 76.2 µM 0.392047773400138 0.338039160645759 no 1134 0.347511457724959 1602 24051409
SGTC_2496 diffractaic acid 79.83 µM 0.390162880452851 0.33870115642187 no 1135 0.348208053964358 1750 94870 An apoptosis inducer which activates caspases.
SGTC_831 k061-1017 217 µM 0.389018683878728 0.339103254580128 no 1136 0.348631162579494 1733 1240153
SGTC_2621 lithochol-11-enic acid 100 µM 0.388919413896797 0.339138149085806 no 1137 0.348667880180609 1788 6708711
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.388038432706984 0.339447884229968 no 1138 0.348993796212457 1719 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3181 9108277 49.47 µM 0.387457646731811 0.339652136166274 no 1139 0.349208716993398 1606 17097298
SGTC_2783 7738165 71.43 µM 0.386552415318997 0.339970583598864 no 1140 0.34954379575268 1539 17201110
SGTC_2188 6126565 140.678 µM 0.386195687203039 0.340096106821489 no 1141 0.349675873787425 1699 874518
SGTC_91 0417-1751 58.384 µM 0.385680954498136 0.340277258932921 no 1142 0.349866484846119 1653 6795624
SGTC_657 3534-0529 86.7 µM 0.385207423963861 0.340443943146953 no 1143 0.350041871720423 1745 1049549
SGTC_2228 7354201 200 µM 0.384772387879557 0.340597104671869 no 1144 0.350203029168635 1735 753451
SGTC_1435 4092-0789 56.7 µM 0.382847326834445 0.341275168954753 no 1145 0.350916484114586 1748 2248285
SGTC_3189 9110682 49.47 µM 0.37742429983031 0.343188072865991 no 1146 0.352929155621683 1645 17122418
SGTC_6 0844-0013 19.835 µM 0.377079505437298 0.343309831311182 no 1147 0.353057260621744 1728 1584900
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.376542668822439 0.343499438669503 no 1148 0.353256750191219 1605 23665772 A membrane-active detergent.
SGTC_2080 5212524 12.4 µM 0.376418451119283 0.343543317203883 no 1149 0.353302915487683 1786 260183
SGTC_2385 9074692 200 µM 0.376175650275828 0.34362909001319 no 1150 0.353393158237771 1625 17046906
SGTC_1596 piperlongumine 63 µM 0.376171807798658 0.343630447486966 no 1151 0.353394586452731 1771 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_689 0833-0039 98 µM 0.375376898190811 0.343911317200216 no 1152 0.353690091722289 1763 5374726
SGTC_753 1322-0200 289 µM 0.374901464125477 0.34407934607759 no 1153 0.353866875071057 1683 5403907
SGTC_2571 chrysanthemic acid 100 µM 0.374699965647419 0.344150569373293 no 1154 0.353941808904673 1582 2743 An insecticide.
SGTC_2451 5856223 45.7 µM 0.373726155046931 0.344494858297957 no 1155 0.354304032089649 1612 2179896
SGTC_1624 st003710 6.25 µM 0.372679572487382 0.344865019293311 no 1156 0.354693470866357 1772 24207033
SGTC_1268 0828-0275 2.46 µM 0.372646387012153 0.344876758943611 no 1157 0.354705821840101 1722 745337
SGTC_382 3229-0966 23.2 µM 0.372228311319982 0.345024669642356 no 1158 0.354861434375295 1751 5722370
SGTC_1143 3454-2408 5.08 µM 0.369376351094273 0.346034293378105 no 1159 0.355923611344307 1669 X1143
SGTC_969 1313-0238 134 µM 0.367844318472359 0.34657710173827 no 1160 0.356494660467796 1671 5212874
SGTC_2836 9010338 19.48 µM 0.365668800153338 0.34734844228416 no 1161 0.357306114980431 1544 2994051
SGTC_2110 5483698 200 µM 0.364803844703443 0.34765529237385 no 1162 0.357628917472576 1693 2848765 YHR062C RPP1
SGTC_2281 7943571 200 µM 0.36343942468201 0.348139534537279 no 1163 0.358138327802877 1837 1244024
SGTC_478 N-arachidonylglycine 10 µM 0.361195252544157 0.348936545342018 no 1164 0.358976745424531 1754 5283389
SGTC_2419 paclitaxel 166.5 µM 0.359972390487588 0.349371121992904 no 1165 0.359433890322812 1719 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_599 1935-0052 86.5 µM 0.357928317256516 0.350097978777301 no 1166 0.36019847930777 1691 9557311
SGTC_3174 9107204 49.47 µM 0.357188585202876 0.350361157388259 no 1167 0.360475315358085 1755 3938802
SGTC_1925 st057770 10.1 µM 0.357043982615134 0.350412611860361 no 1168 0.360529439733758 1581 5989122
SGTC_1382 3002-2117 298 µM 0.357035984809517 0.350415457829155 no 1169 0.360532433373338 1814 1497314
SGTC_2149 5554786 194.827 µM 0.356033647499097 0.350772199682309 no 1170 0.360907683480028 1710 745063 YPR165W RHO1
SGTC_1023 4482-3888 16 µM 0.355862014278564 0.350833298864702 no 1171 0.360971952119983 1793 3303168
SGTC_937 3122-0005 46.7 µM 0.355625491662538 0.35091750414436 no 1172 0.361060525245445 1815 759535
SGTC_3318 9139014 38.6185 µM 0.355435354959437 0.350985200715246 no 1173 0.361131733149765 1693 16643984
SGTC_1880 MG-132 525 µM 0.354599259727997 0.351282941482174 no 1174 0.361444915408355 1785 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_280 3448-3607 3.04 µM 0.35342098751578 0.351702689395138 no 1175 0.36188642698898 1806 626179
SGTC_3197 9113331 49.47 µM 0.352919102475146 0.351881535968436 no 1176 0.362074544722324 1806 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1318 1280-3875 124 µM 0.351182985378541 0.352500453323386 no 1177 0.36272553696942 1727 373245
SGTC_634 1611-4317 11.2 µM 0.350059923910319 0.352901027546026 no 1178 0.363146863191298 1807 2843522
SGTC_3306 9127676 59.7925 µM 0.34977547272897 0.353002511665013 no 1179 0.363253603825274 1669 41905287
SGTC_1657 st012939 43.4 µM 0.346318189756661 0.354236806283496 no 1180 0.364551800000226 1795 24207257
SGTC_458 nppb 133 µM 0.346000262407403 0.354350387602798 no 1181 0.364671258765746 1853 4549 A chloride channel blocker.
SGTC_2082 5219693 150 µM 0.34506500659931 0.354684588039626 no 1182 0.3650227501211 1660 2834649
SGTC_2738 aclarubicin 5.55 µM 0.343087512063721 0.355391585849193 no 1183 0.365766312769173 1769 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2068 5226020 147 µM 0.340836990846678 0.356196802470708 no 1184 0.366613150681983 1680 1810509
SGTC_1902 st060212 70.5 µM 0.337641650575339 0.357341168691884 no 1185 0.367816625453387 1699 688944
SGTC_546 peri-Naphthalide 147 µM 0.335314586686699 0.35817538276705 no 1186 0.368693895725445 1806 223824 A penicillin ester.
SGTC_2329 6138490 200 µM 0.335010717624597 0.358284364916367 no 1187 0.368808500716298 1732 720019
SGTC_404 fumagillin 50 µM 0.334150791352377 0.358592838631265 no 1188 0.369132887296845 1751 12015870 A methionine aminopeptidase binder.
SGTC_1616 st002734 56.1 µM 0.331333805999619 0.359603996103873 no 1189 0.370196179283542 1759 4026101
SGTC_2304 7443016 91.4 µM 0.329739537674784 0.360176695435693 no 1190 0.370798388130021 1708 939854
SGTC_662 k832-1615 104 µM 0.329080862788374 0.360413398935942 no 1191 0.371047284339359 1789 5878478
SGTC_1278 0874-0585 172 µM 0.328523496362283 0.360613737706087 no 1192 0.371257940850725 1787 766306
SGTC_679 0422-0091 41.4 µM 0.328087677041879 0.360770414466833 no 1193 0.37142268553959 1670 627384 YHR062C RPP1
SGTC_345 1362-0200 395 µM 0.326080759163183 0.361492201371651 no 1194 0.372181627043578 1671 1419823
SGTC_2338 7999974 200 µM 0.325850800507885 0.361574937416452 no 1195 0.372268620608822 1920 315925
SGTC_3301 9125354 19.7965 µM 0.324639772682133 0.36201075572603 no 1196 0.372726860984753 1697 41905162
SGTC_234 nsc-17383 10.7 µM 0.322641395912321 0.362730312159001 no 1197 0.373483419756199 1849 408974
SGTC_2624 nerol 100 µM 0.322333467721205 0.362841231192264 no 1198 0.373600040714316 1827 637566 A natural product oil.
SGTC_913 3487-1245 167 µM 0.322065967777762 0.362937596879453 no 1199 0.373701359768482 1650 4016153
SGTC_1029 k015-0030 64.7 µM 0.321939210402776 0.362983263701876 no 1200 0.373749373808023 1786 2208316
SGTC_1062 mesoridazine 14.2 µM 0.321520772763045 0.363134027870426 no 1201 0.373907886431943 1739 4078 A neuroleptic.
SGTC_1262 0737-0114 49.6 µM 0.321503551694148 0.363140233120855 no 1202 0.37391441057754 1880 765919
SGTC_3122 9126309 49.47 µM 0.321175217004516 0.363258548499337 no 1203 0.374038806007896 1883 17591206
SGTC_1009 4106-0057 9.87 µM 0.320866961647767 0.363369640167899 no 1204 0.374155605966173 1871 2928005
SGTC_909 3448-9333 149 µM 0.320602126260106 0.363465092960136 no 1205 0.374255963043047 1669 3344074
SGTC_1608 st001473 40.5 µM 0.320229083451758 0.363599560586502 no 1206 0.374397338838706 1678 7292267
SGTC_574 1315-0397 40 µM 0.319149967219571 0.363988635171057 no 1207 0.374806397433167 1758 6794277
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.317764200092721 0.364488478174137 no 1208 0.375331904209533 1739 61125 An anti-inflammatory.
SGTC_3305 9127027 53.8275 µM 0.317375591036412 0.364628689983803 no 1209 0.375479313054349 1766 41905295
SGTC_3165 9101544 49.47 µM 0.316490584227435 0.364948071787511 no 1210 0.37581508543275 1821 5002184
SGTC_2993 9054257 71.4286 µM 0.316107704260311 0.365086274804897 no 1211 0.375960379599754 1727 6470217 YGL055W OLE1
SGTC_1962 st076595 64.5 µM 0.315726539755611 0.365223876023997 no 1212 0.37610504025633 1752 279619
SGTC_1987 st072290 61.9 µM 0.31543160067283 0.365330361587408 no 1213 0.37621698833995 1761 54697379
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.31430004569281 0.365738997366847 no 1214 0.376646581761326 1743 91467 include heat shock
SGTC_3111 9122088 49.47 µM 0.314009954259771 0.365843781962004 no 1215 0.376756739237241 1846 16876704
SGTC_2899 9053889 58.44 µM 0.31335729223938 0.366079568095813 no 1216 0.377004613635325 1902 6470052
SGTC_3161 9100388 49.47 µM 0.313190441797187 0.366139854002292 no 1217 0.377067989877576 1806 25236368
SGTC_795 0685-0265 78 µM 0.311458635282853 0.366765780087231 no 1218 0.377725992170455 1740 302754
SGTC_1002 4049-0206 172 µM 0.307462853567169 0.368211323663439 no 1219 0.379245546553251 1730 4662749
SGTC_1238 0333-0287 48.8 µM 0.306431400513523 0.368584773881552 no 1220 0.379638101679348 1751 7226
SGTC_1445 4239-0156 97.7 µM 0.304770084154414 0.369186534728695 no 1221 0.380270633804583 1891 4008346
SGTC_1159 4092-0538 61.2 µM 0.304115898481765 0.369423581496433 no 1222 0.380519797451576 1798 717301
SGTC_2922 7999257 32.47 µM 0.302915426312705 0.369858706431896 no 1223 0.380977157423799 1755 2988377
SGTC_1488 4013-0813 75.9 µM 0.302231760068647 0.370106583644994 no 1224 0.381237697296249 1768 2910057
SGTC_863 0466-0191 129 µM 0.301971923347993 0.370200806932805 no 1225 0.381336733169356 1874 765160 YPR165W RHO1
SGTC_2347 9049783 174.81 µM 0.300113599887059 0.370874908223561 no 1226 0.382045252936638 1853 6467988 YPL169C MEX67
SGTC_2064 5220758 200 µM 0.299727671740224 0.371014952297058 no 1227 0.382192444732675 1796 788518
SGTC_1271 0832-2808 169 µM 0.297992459097428 0.371644830227078 no 1228 0.382854459543645 1905 3663794
SGTC_1428 4049-0204 61.7 µM 0.297889434060181 0.371682238891223 no 1229 0.382893776233278 1881 X1428
SGTC_1921 5740136 50 µM 0.297603852771526 0.371785940547946 no 1230 0.383002766833746 1932 1774243
SGTC_877 0771-0151 33.1 µM 0.295189981538731 0.372662848103159 no 1231 0.383924377383863 1805 6166523
SGTC_3282 9108498 15.4605 µM 0.293431348009557 0.373302138006721 no 1232 0.384596233596264 1760 16459645
SGTC_2070 5230947 200 µM 0.29132498423084 0.374068292238558 no 1233 0.385401390535453 1904 2835538
SGTC_3078 9116413 49.47 µM 0.289302321199388 0.374804470267488 no 1234 0.386175018085884 1781 17177322
SGTC_138 0850-0259 40.9225 µM 0.288586867376774 0.375064979657747 no 1235 0.386448773214671 1840 6813004
SGTC_3019 9081971 49.47 µM 0.287364265011715 0.375510282682128 no 1236 0.386916710086872 1917 16451803
SGTC_3310 9130229 44.1445 µM 0.286936489729639 0.375666128581552 no 1237 0.387080474977581 1884 7761258
SGTC_2840 9008771 71.43 µM 0.285770781048306 0.376090919224429 no 1238 0.387526844307701 1953 2992978
SGTC_981 1488-1094 54.9 µM 0.285402877268629 0.376225016582006 no 1239 0.38766775171359 1786 3449522
SGTC_2303 7774051 200 µM 0.283809283015009 0.376806038583778 no 1240 0.388278270057246 1895 2953184
SGTC_2242 6630449 61.2675 µM 0.282157182308936 0.377408686645196 no 1241 0.388911494240566 1844 691249 YDR170C SEC7
SGTC_1685 st024049 53.0905 µM 0.281874974392851 0.377511659457799 no 1242 0.389019689658767 1835 1941139
SGTC_1350 1495-0454 146 µM 0.280022300839591 0.378187884067366 no 1243 0.389730197728525 1902 1069057
SGTC_2673 kobusone 100 µM 0.279953909500417 0.378212854017839 no 1244 0.389756433163933 1865 6710676 An epoxy ketone and protein crosslinker.
SGTC_1648 st011736 69.8 µM 0.276746888005868 0.379384319851493 no 1245 0.39098723298894 1897 2855514
SGTC_1755 st041960 45.185 µM 0.27634556213701 0.379530995034836 no 1246 0.391141332148914 1844 2257073
SGTC_2227 7312221 64.1025 µM 0.27632652590229 0.379537952762597 no 1247 0.391148642014717 1892 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2158 5657123 3.6195 µM 0.276267641542321 0.379559475193529 no 1248 0.39117125370287 1895 2858827
SGTC_2484 5809818 12.04 µM 0.275910409045035 0.379690052865822 no 1249 0.391308439434038 1806 2870548
SGTC_1201 1889-3372 45.9 µM 0.275821885322948 0.379722412686569 no 1250 0.391342436729057 1808 5392199
SGTC_2111 5486399 200 µM 0.274786451566709 0.38010097768596 no 1251 0.391740153825264 1789 689674
SGTC_744 1594-0068 283 µM 0.274597317188922 0.380170139538751 no 1252 0.391812813852799 1801 668392
SGTC_1225 1216-0074 20.6 µM 0.273571809693943 0.380545209407462 no 1253 0.392206850192743 1795 4241466
SGTC_2065 5221596 34.26 µM 0.270740832835512 0.381581194987507 no 1254 0.393295184596654 1860 788581
SGTC_1425 4048-4433 7.33 µM 0.267917855047384 0.382615098760378 no 1255 0.394381274815101 1922 23734946
SGTC_1431 4049-0260 9.09 µM 0.267692407549034 0.382697704156917 no 1256 0.394468047248114 1894 3854841
SGTC_1285 0929-0069 65.5 µM 0.267323761403976 0.382832789944182 no 1257 0.394609946654577 1846 1206237
SGTC_1223 0764-0573 147 µM 0.266046805387105 0.383300824670992 no 1258 0.395101581027811 1828 1609797
SGTC_1839 st053978 48 µM 0.26601067857153 0.383314068488882 no 1259 0.395115492463652 1950 3788398
SGTC_1491 4138-0063 26.5 µM 0.265841150670621 0.383376217958766 no 1260 0.395180774747147 1953 23883227
SGTC_314 1671-0008 2.74 µM 0.265277850562768 0.383582747123027 no 1261 0.395397713065886 1869 3913060
SGTC_1432 4049-0298 68.4 µM 0.264706490430557 0.383792265220056 no 1262 0.395617788582365 1975 741646
SGTC_2023 5144124 124 µM 0.263260861116061 0.38432252994663 no 1263 0.396174762110357 1821 2830192
SGTC_2843 9000894 45.46 µM 0.26298313016461 0.384424428005638 no 1264 0.396281790884554 1843 2242070
SGTC_1849 st056239 19.2 µM 0.262669476296281 0.384539515601291 no 1265 0.396402672620393 1736 5393181
SGTC_119 0121-0043 24.815 µM 0.262456647113372 0.384617613847381 no 1266 0.396484702344455 1940 1092378
SGTC_3121 9125696 49.47 µM 0.262440662741631 0.384623479545054 no 1267 0.396490863308692 1997 1235365
SGTC_741 4582-0002 126 µM 0.262184414107446 0.384717517312955 no 1268 0.39658963447575 1808 2912688
SGTC_2964 9083345 53.42 µM 0.260511230270081 0.385331706497646 no 1269 0.397234726897355 1784 17741579
SGTC_1451 4152-0210 104 µM 0.259541886380952 0.385687663164918 no 1270 0.397608584119086 1965 659563
SGTC_3060 1327-0027 12.5 µM 0.258156119817845 0.386196703235782 no 1271 0.398143210810145 1968 16000455 YPR107C YTH1
SGTC_824 1304-0008 100 µM 0.256690433241424 0.386735313930826 no 1272 0.398708878664439 1859 768245
SGTC_2399 5884133 200 µM 0.255607126817557 0.387133547841418 no 1273 0.39912710738832 1801 722445
SGTC_1877 wortmannin 25 µM 0.250144706728899 0.389143388395326 no 1274 0.401237721851013 1967 312145 A covalent inhibitor of PI 3-kinase.
SGTC_290 2043-6722 48.1 µM 0.248949399117917 0.389583587272152 no 1275 0.401699961460295 1898 773758 YLR208W SEC13
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.24727046827209 0.39020213045198 no 1276 0.402349456082055 1892 7104
SGTC_2257 7960413 200 µM 0.247266596409651 0.390203557225852 no 1277 0.40235095422491 1915 2974689 YIL048W NEO1
SGTC_3096 9117468 49.47 µM 0.244211384221645 0.391329856574668 no 1278 0.403533555309892 1942 41316311
SGTC_2674 ligustilide 100 µM 0.240763036814698 0.392602179641367 no 1279 0.404869389663537 1901 5319022 A signalling regulator.
SGTC_2780 5215298 71.43 µM 0.238782792971336 0.39333334246108 no 1280 0.405637006775547 2050 2834131
SGTC_1668 st014914 51.6 µM 0.238543131463295 0.393421857945288 no 1281 0.405729933289144 1942 2839556
SGTC_1940 st075990 51.1 µM 0.238506099190904 0.393435535766723 no 1282 0.405744292681246 1939 1084979
SGTC_2777 climbazole 1.536 µM 0.237670058671682 0.393744361208848 no 1283 0.40606850401004 1932 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2933 9026794 32.47 µM 0.235880378219701 0.394405676667103 no 1284 0.406762747294628 1927 17586027
SGTC_2116 5511452 16.8835 µM 0.235551666029991 0.394527174215125 no 1285 0.406890291499015 1917 870744
SGTC_1971 st069429 63.5 µM 0.235342758131855 0.394604395417712 no 1286 0.406971355359598 2009 1246522 YGL099W LSG1
SGTC_1415 3966-0071 78.1 µM 0.235167185527928 0.394669297687545 no 1287 0.407039486996431 1913 2893185
SGTC_1719 st032227 49.2 µM 0.234685554238294 0.394847352792438 no 1288 0.407226400342619 1801 3125804
SGTC_2676 harmalol 100 µM 0.234173453046032 0.395036696460994 no 1289 0.407425161741952 1971 5459187 A monoamine oxidase inhibitor
SGTC_3303 9125618 40.5795 µM 0.232699931922597 0.395581652497833 no 1290 0.407997211040641 1941 22695467
SGTC_2915 7971052 15.16 µM 0.231168584882269 0.396148210835087 no 1291 0.408591917340378 1989 5741558
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.231146716260127 0.396156303245009 no 1292 0.408600411657514 1945 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2175 5807670 165.306 µM 0.230055364924789 0.396560210898153 no 1293 0.409024374139059 2008 241186
SGTC_1206 3978-0017 132 µM 0.229967894055379 0.396592588560224 no 1294 0.409058358981293 1949 3873677
SGTC_800 3448-7362 155 µM 0.22945702256412 0.396781703746847 no 1295 0.409256860276187 2008 15991913
SGTC_2540 epiandrosterone 100 µM 0.229162371780204 0.396890789065781 no 1296 0.409371358678184 2019 441302 A steroid.
SGTC_2313 7726885 200 µM 0.22884024365166 0.397010056251952 no 1297 0.409496543352851 1896 726423
SGTC_2455 5377712 9.75 µM 0.227986583123036 0.397326168627872 no 1298 0.409828335497196 1809 2243908
SGTC_3322 9139058 2.11 µM 0.226100398908974 0.398024865693128 no 1299 0.410561667169542 1972 4908926 YPR165W RHO1
SGTC_2947 9072639 7.68 µM 0.2259503548347 0.398080460424728 no 1300 0.410620016437319 1857 16488146
SGTC_2416 tofa 880 nM 0.225629441048022 0.398199373203474 no 1301 0.410744820303372 1762 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1020 4335-0961 93.3 µM 0.222239689133057 0.399456001860138 no 1302 0.412063649544642 1819 669075
SGTC_2975 9084847 53.72 µM 0.220558657915777 0.400079571217863 no 1303 0.41271804723881 1865 27211724
SGTC_1461 k072-0203 53.8 µM 0.21815405189861 0.400971989353745 no 1304 0.413654542051791 2016 5418714
SGTC_1563 conessine 56.1 µM 0.215681252471744 0.401890255214084 no 1305 0.414618107823776 2034 441082 An anti-amoebic, histamine inhibitor.
SGTC_1086 cerivastatin 2.18 µM 0.215528981931714 0.40194681813632 no 1306 0.41467745932944 2030 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.215481164472768 0.401964580992764 no 1307 0.414696097861819 1986 616764
SGTC_3016 9080866 49.47 µM 0.21516560540702 0.402081807487555 no 1308 0.41481910289324 1928 17066299
SGTC_41 0478-0632 82.643 µM 0.215117264297471 0.40209976642155 no 1309 0.414837947012248 2082 3750424
SGTC_1103 duloxetine 36.1 µM 0.214913562804146 0.40217544468882 no 1310 0.414917355185872 2008 60835 A selective serotonin reuptake inhibitor.
SGTC_31 0508-1974 57.237 µM 0.214524535983688 0.402319984379631 no 1311 0.415069017679313 1995 6810525
SGTC_1068 loratadine 26.9 µM 0.213787220564819 0.402593964443283 no 1312 0.415356495540432 1898 3957 A H1 histamine antagonist.
SGTC_2865 9030313 51.95 µM 0.210512963428438 0.403811226474553 no 1313 0.416633667496427 1850 42562754
SGTC_668 1682-0499 62.6 µM 0.209399011530455 0.40422557057853 no 1314 0.417068382172601 1914 682214
SGTC_943 3253-1379 105 µM 0.209149643706822 0.40431833984782 no 1315 0.417165710745325 1980 668464
SGTC_3319 9138450 16.7555 µM 0.207580340514501 0.404902271836002 no 1316 0.417778327997943 1923 2029690
SGTC_1635 st007035 42.4 µM 0.207357632031811 0.404985158042346 no 1317 0.417865284101841 1984 3716403
SGTC_3219 9131112 49.47 µM 0.206935705880795 0.405142199480096 no 1318 0.418030035373092 2047 17612988 YMR079W SEC14
SGTC_2600 tangeritin 87.95 µM 0.206691966542409 0.405232926527305 no 1319 0.418125215850542 1902 68077 A bioactive flavone.
SGTC_2469 5655019 90.81 µM 0.206091468168974 0.405456471642374 no 1320 0.418359731568868 2029 2788239
SGTC_3142 9086498 49.47 µM 0.205839280556157 0.405550361711476 no 1321 0.418458228353307 2079 25236367
SGTC_148 3253-0744 288.01 µM 0.204974042368761 0.405872533295774 no 1322 0.418796202809357 2050 6893655
SGTC_454 lyso-paf C-16 6.67 µM 0.203155389248085 0.406549916703005 no 1323 0.419506789954388 1858 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2507 purpurin 79.67 µM 0.202783241469762 0.406688563017758 no 1324 0.419652228585556 1843 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2734 clemastine 41.6 µM 0.202371130033693 0.406842111727183 no 1325 0.419813298172812 2046 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2393 9031399 185.94 µM 0.200750579280663 0.407446051836176 no 1326 0.420446804073541 2012 1526623 YDL150W RPC53
SGTC_2427 5545055 42.75 µM 0.200733788026438 0.40745231068527 no 1327 0.420453369194443 1968 5372858
SGTC_1357 1503-1303 39.5 µM 0.194319067309654 0.409845077346871 no 1328 0.422963028315321 1964 292895
SGTC_445 e6 berbamine 66 µM 0.193169594403197 0.410274202032279 no 1329 0.423413075195275 1966 6610268 A calcium/calmodulin antagonist.
SGTC_2823 7987624 58.44 µM 0.192571735738407 0.410497438941947 no 1330 0.423647191093721 1973 2239440
SGTC_3192 9110362 49.47 µM 0.191705511520575 0.410820933402138 no 1331 0.423986444248666 2002 16649480
SGTC_2744 captopril 92.04 µM 0.191647229269769 0.410842701292962 no 1332 0.424009272278335 2080 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3209 9113616 49.47 µM 0.191618249466525 0.410853525088227 no 1333 0.424020623201319 2126 16649353
SGTC_3238 9133470 49.47 µM 0.191096867730461 0.411048269854228 no 1334 0.424224850803832 2077 3534688
SGTC_1473 k844-0725 134 µM 0.190377919822376 0.411316844828959 no 1335 0.424506499341677 2064 54682906
SGTC_1210 3013-0140 750 nM 0.19020159410811 0.411382720590738 no 1336 0.424575581003099 2098 905973
SGTC_154 3389-1638 511.116 µM 0.189356169157706 0.411698608306541 no 1337 0.424906837445862 1824 5238686
SGTC_997 3996-0078 137 µM 0.18918287423907 0.411763365938557 no 1338 0.424974744835834 1961 735687
SGTC_3250 9135583 49.47 µM 0.189078343358304 0.411802428674861 no 1339 0.425015707409412 2082 7699353
SGTC_905 2-aminofluorene 215 µM 0.188714833421281 0.411938277562664 no 1340 0.425158162548196 2052 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1818 st052136 56.3 µM 0.187026792837765 0.412569260645942 no 1341 0.42581981296706 1990 674169
SGTC_1513 0337-0559 19 µM 0.186704012500534 0.412689940486008 no 1342 0.425946354951338 1903 775073
SGTC_1265 0819-1001 68.8 µM 0.18495530205849 0.413343884647143 no 1343 0.426632047205541 2046 3106768
SGTC_3066 9117245 49.47 µM 0.184400037567474 0.413551580601834 no 1344 0.426849820174675 2025 17176980
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.184300422505823 0.413588844045822 no 1345 0.42688889124631 2088 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2378 9074213 121.43 µM 0.183135735487994 0.414024581294611 no 1346 0.427345758521115 2068 657714
SGTC_2948 9070189 9.45 µM 0.182344256854413 0.414320752815322 no 1347 0.427656284440006 2102 6473636 YDL196W YDL196W
SGTC_324 1315-0088 19.6 µM 0.182328738195549 0.4143265603893 no 1348 0.427662373424178 2035 6787421
SGTC_796 1234-0020 70.7 µM 0.182272202448405 0.414347718016074 no 1349 0.427684556238664 2087 46495034
SGTC_2784 7567673 72.73 µM 0.18180170483516 0.414523804088066 no 1350 0.42786917327725 2043 3471247
SGTC_3082 9117008 49.47 µM 0.18108849144313 0.414790760494936 no 1351 0.428149058877088 1957 41448529
SGTC_217 ketoconazole 989 nM 0.178538781754613 0.415745440102094 no 1352 0.429149933497118 2042 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1683 st010134 710 nM 0.178344204876417 0.415818315399214 no 1353 0.429226332384088 1898 3818134
SGTC_325 2810-4341 181 µM 0.177434509972686 0.416159063757722 no 1354 0.429583551153774 2098 774970
SGTC_1147 3809-1045 12.3 µM 0.176906904292872 0.41635672019682 no 1355 0.429790757660288 1960 325925
SGTC_2998 9066762 71.4286 µM 0.176606264763895 0.416469357976154 no 1356 0.429908836435349 2059 4945196
SGTC_707 0865-0008 204 µM 0.176360331593967 0.416561504540627 no 1357 0.430005433477303 2031 723043
SGTC_2868 9035608 32.47 µM 0.176132291610641 0.416646950959495 no 1358 0.430095006219985 2052 6462614
SGTC_2002 4023503 131 µM 0.174987222014291 0.41707606718031 no 1359 0.430544837013085 2152 4736863 YCR052W RSC6
SGTC_1332 1480-0653 17.5 µM 0.174333962357679 0.417320921325605 no 1360 0.430801504898627 2125 5749438
SGTC_730 1436-0052 41.2 µM 0.174098386788056 0.417409227401849 no 1361 0.430894070498308 2110 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1733 st037357 54.9 µM 0.173409120999852 0.417667624271269 no 1362 0.431164928097922 1861 1272339 YGL099W LSG1
SGTC_3316 9136639 10.545 µM 0.173245518831463 0.41772896184279 no 1363 0.431229222846939 2047 4903665
SGTC_2962 9082311 13.18 µM 0.172730693662444 0.417921992665147 no 1364 0.431431558178654 1975 16459453
SGTC_1375 2910-0797 186 µM 0.170932542308463 0.418596354338356 no 1365 0.432138404075284 2006 742508
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.170561112883426 0.418735681602575 no 1366 0.432284438604435 2138 688664
SGTC_719 2810-4230 27.3 µM 0.170365215894231 0.418809168825944 no 1367 0.432361462952135 2040 721079
SGTC_872 0588-0139 234 µM 0.169819449179444 0.419013918302673 no 1368 0.4325760654299 2109 2047100
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.167872991977697 0.419744328145149 no 1369 0.433341598924898 1989 688803
SGTC_1072 oxiconazole 14.9 nM 0.16689716689587 0.420110611638688 no 1370 0.433725481187104 2093 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2439 5492030 7.2 µM 0.166837945959865 0.420132842905713 no 1371 0.433748780274775 2118 5722370
SGTC_776 4476-4378 112 µM 0.166399303751127 0.420297515102698 no 1372 0.433921360921149 1950 2892008
SGTC_3036 9090181 49.47 µM 0.165892882424512 0.420487649844496 no 1373 0.434120624442857 2027 25236586
SGTC_1458 k015-0034 6.33 µM 0.165211504332242 0.420743500976023 no 1374 0.434388755273992 1935 3598957
SGTC_2255 7941087 197.44 µM 0.164015935833958 0.421192506671925 no 1375 0.434859299358815 2126 935561
SGTC_66 0109-0187 42.4 µM 0.163172099072607 0.421509478333946 no 1376 0.435191466739917 2060 759417
SGTC_765 1319-0117 244 µM 0.163117087012042 0.421530144364772 no 1377 0.435213123244062 2123 3487746 YGL099W LSG1
SGTC_2711 st079103 59.1 µM 0.162099071484813 0.421912614732024 no 1378 0.435613918687369 2096 54693780
SGTC_1413 3910-0535 34.4 µM 0.162010578152921 0.421945865330092 no 1379 0.435648761880069 2109 2876951
SGTC_447 ml7 120 µM 0.161125380608475 0.422278501173562 no 1380 0.43599732528948 2141 4216 Selective myosin light chain kinase inhibitor.
SGTC_2749 bexarotene 57.39 µM 0.159800566793173 0.422776437699569 no 1381 0.43651908879172 1981 82146 An retinoic acid receptor inhibitor.
SGTC_977 1348-1378 135 µM 0.159472962369102 0.422899588183925 no 1382 0.436648129299713 2104 X977
SGTC_3323 9138564 53.9225 µM 0.15777437149106 0.423538229690172 no 1383 0.437317297137185 2120 43912313 YNL103W MET4
SGTC_2405 ticlatone 3.52 µM 0.157290699017425 0.423720119202144 no 1384 0.437507875064414 2137 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1830 st055982 50.3 µM 0.157152949918719 0.423771924001453 no 1385 0.437562153988869 2159 455313 An antimicrobial agent.
SGTC_3212 9128307 49.47 µM 0.156494762799924 0.424019473750002 no 1386 0.437821523532509 1814 27243542
SGTC_2481 5478948 45.16 µM 0.154593146818584 0.424734855740728 no 1387 0.43857103654503 2015 77792
SGTC_263 alizarin 107.927 µM 0.153698178980605 0.425071625804552 no 1388 0.438923860342121 2111 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2430 5571206 200 µM 0.153683423010343 0.425077178830668 no 1389 0.438929678006083 2140 1731771
SGTC_1933 st074711 15.9 µM 0.152169803189439 0.425646869110219 no 1390 0.439526505067756 2148 17250958
SGTC_3178 9107506 49.47 µM 0.15076135166466 0.426177116032388 no 1391 0.440081987312541 2090 8897194
SGTC_1613 st002381 52.1 µM 0.150285975255327 0.426356113589914 no 1392 0.440269498723477 2176 551167
SGTC_1153 4055-0057 267 µM 0.149590677308353 0.426617947403344 no 1393 0.440543781923856 1978 882706
SGTC_1187 1391-0724 117 µM 0.148053711318052 0.427196849373055 no 1394 0.441150189885593 2033 6997986
SGTC_2890 9046729 58.44 µM 0.143796290066422 0.428801232500701 no 1395 0.442830666263882 2011 903329
SGTC_965 1291-5240 308 µM 0.143569893196419 0.42888658197273 no 1396 0.442920058029473 2127 2834598
SGTC_1400 3771-8998 51.5 µM 0.142256863153145 0.429381647288545 no 1397 0.443438559070293 2117 670767
SGTC_541 4513-1321 94 µM 0.141591362651096 0.429632610305432 no 1398 0.443701394899581 1980 747515
SGTC_2235 salicylic acid 500 µM 0.139440625713666 0.430443856143467 no 1399 0.444550985621196 2169 338 A COX inhibitor and kinase inhibitor.
SGTC_3113 9123498 49.47 µM 0.139106553384279 0.43056989277678 no 1400 0.444682974863352 2189 8897275
SGTC_2361 9034121 116 µM 0.138166240368931 0.43092468587998 no 1401 0.445054517720622 2045 6496917
SGTC_1071 trifluoperazine 6.31 µM 0.137977685872469 0.430995836818837 no 1402 0.445129026473207 2111 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_772 k072-0172 35.3 µM 0.136466566726643 0.431566137530558 no 1403 0.445726226570711 1943 5861980
SGTC_2435 5706476 10.6 µM 0.136322258572721 0.431620607324741 no 1404 0.445783264171822 2184 5725375
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.136103035598318 0.431703356559235 no 1405 0.44586991390025 2117 6708784 An antioxidant flavonoid
SGTC_2337 9009472 200 µM 0.135786464499369 0.431822856695522 no 1406 0.445995045856782 2162 5742383
SGTC_2666 tannic acid 100 µM 0.135549074593586 0.431912471389406 no 1407 0.446088883168276 2138 16134267 A thiamine antagonist.
SGTC_2141 5621638 7.665 µM 0.135383324679212 0.431975044062715 no 1408 0.446154403862331 2153 2856238
SGTC_1105 epirubicin 18.1 µM 0.134915162584754 0.432151790342611 no 1409 0.446339475575818 2024 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.134761905185189 0.432209652902693 no 1410 0.446400063136859 2029 688667
SGTC_2181 6316240 54.2555 µM 0.134280639072878 0.432391365089084 no 1411 0.446590331180913 2041 12779990
SGTC_2951 9072950 58.06 µM 0.133998127824539 0.432498039842334 no 1412 0.446702027432021 2191 16488155
SGTC_2092 5303694 80.6725 µM 0.133655644315152 0.432627366401561 no 1413 0.446837440538369 2050 1963699
SGTC_1184 1269-1718 139 µM 0.133438528944892 0.432709355938464 no 1414 0.446923288077753 2147 5403821
SGTC_90 0870-0863 4.608 µM 0.133307217645475 0.432758944587698 no 1415 0.446975209846576 2079 1738164
SGTC_1985 st071382 65.5 µM 0.132899414638887 0.432912954839728 no 1416 0.447136464924216 2197 6123237
SGTC_635 k038-0028 24.7 µM 0.132140639423515 0.433199539816084 no 1417 0.447436526059762 2097 4035102
SGTC_1197 1601-0112 267 µM 0.132113570510272 0.433209764236748 no 1418 0.447447231142355 2037 7350313
SGTC_2033 5192550 145 µM 0.129726886901392 0.434111433002674 no 1419 0.448391254822124 2064 182073
SGTC_309 k408-0051 1.48 µM 0.129546499038387 0.434179595999927 no 1420 0.44846261699637 2101 3640463
SGTC_899 1083-0020 478 µM 0.128366088476427 0.434625684875452 no 1421 0.448929633285611 2154 767123
SGTC_914 3820-6779 408 µM 0.128166412451842 0.434701152675336 no 1422 0.449008639896074 2128 2893481
SGTC_282 k297-0036 65.7 µM 0.127811098292018 0.434835449982603 no 1423 0.44914923346755 2143 5061378
SGTC_2060 5238662 140 µM 0.12726366519311 0.43504237677085 no 1424 0.449365858700433 2076 790130
SGTC_2740 felodipine 17.08 µM 0.126978775101573 0.435150070746546 no 1425 0.449478598783936 2196 3333 L-type calcium channel blocker
SGTC_166 k072-0058 166.424 µM 0.12650067368868 0.435330813153015 no 1426 0.449667807902232 2206 5846229
SGTC_268 camptothecin 39.6153 µM 0.126049662838747 0.435501326574711 no 1427 0.449846306393001 2192 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.122931742341624 0.436680443393236 no 1428 0.451080574752131 2179 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3157 9099274 49.47 µM 0.121592886280365 0.437186937435587 no 1429 0.451610723805189 2197 17217662
SGTC_47 0149-0135 24.25 µM 0.120887876136162 0.437453686735331 no 1430 0.451889922591268 2185 5239155
SGTC_1227 3909-8010 46.6 µM 0.1203436932403 0.437659604507442 no 1431 0.452105446697867 2101 15982272
SGTC_2096 5468907 200 µM 0.119763244783347 0.437879263707744 no 1432 0.452335349366998 2173 759785
SGTC_2988 9073640 71.4286 µM 0.119521654614809 0.437970694358922 no 1433 0.452431042551501 2137 9102229
SGTC_3290 9121031 71.43 µM 0.118296356521652 0.438434463631992 no 1434 0.452916422102397 2086 17014854
SGTC_2051 5263410 176 µM 0.117448025410231 0.438755602340229 no 1435 0.453252514303944 2225 227584
SGTC_3185 9108267 49.47 µM 0.116598263012111 0.4390773232928 no 1436 0.453589207126115 2070 4910486
SGTC_501 nsc-95397 161 µM 0.115166240698507 0.439619579433497 no 1437 0.454156678306086 2165 262093
SGTC_708 3448-5400 146 µM 0.114534616021218 0.43985878940147 no 1438 0.454407003661308 2211 3462195
SGTC_2134 5324836 1.464 µM 0.114130032208899 0.440012025610596 no 1439 0.454567357751662 2136 699272
SGTC_823 0417-1665 178 µM 0.113738000161966 0.440160516408548 no 1440 0.454722744097474 2114 3429856
SGTC_1154 4088-0362 150 µM 0.113069150634271 0.440413877361267 no 1441 0.454987866171478 2211 6618304
SGTC_3247 9135149 49.47 µM 0.112182805999742 0.440749663276011 no 1442 0.455339230965149 2208 8934436 YOR116C RPO31
SGTC_912 3474-0017 2.18 µM 0.109780577100258 0.441659945652806 no 1443 0.456291697578563 2167 3360550
SGTC_1504 k297-0033 30 µM 0.108441346737011 0.442167557559213 no 1444 0.456822802271741 2079 4388117
SGTC_2809 7964133 12.99 µM 0.107754741068702 0.442427840340999 no 1445 0.457095122583564 2129 1253665
SGTC_901 1112-0062 60.1 µM 0.106263252900417 0.442993328512342 no 1446 0.457686743202825 2215 1908457
SGTC_1266 0828-0227 32.9 µM 0.105366502244602 0.443333381751455 no 1447 0.458042497703188 2152 3913820
SGTC_1326 1431-2094 10.8 µM 0.105000109605545 0.443472332067066 no 1448 0.458187860874387 2180 616278
SGTC_3000 9075062 71.4286 µM 0.104930014405411 0.443498915681324 no 1449 0.458215671188259 2102 17057871
SGTC_2367 9070478 135.38 µM 0.104111988747579 0.443809170792615 no 1450 0.458540238459487 2167 572802
SGTC_335 4077-0256 27.6 µM 0.103258267949122 0.44413300083806 no 1451 0.458878997933807 2218 3121989
SGTC_672 1441-0018 53.7 µM 0.102797169857396 0.444307918296685 no 1452 0.459061975746482 2155 251141
SGTC_1315 1237-0019 3.69 µM 0.102606759605323 0.44438015355015 no 1453 0.45913753888544 2220 825140
SGTC_2677 mitomycin C 100 µM 0.101229757245589 0.444902596834086 no 1454 0.459684037588978 2210 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3248 9135562 49.47 µM 0.100406571854719 0.445214964280704 no 1455 0.460010776274736 2156 17650701
SGTC_94 0334-0113 514.748 µM 0.100331596556641 0.445243416238759 no 1456 0.460040536809837 2212 6795178
SGTC_486 niguldipine 82 µM 0.0995545719681253 0.445538301552027 no 1457 0.460348980447044 2246 1236 A calcium channel blocker.
SGTC_784 4579-0127 173 µM 0.0994876498948717 0.445563700276533 no 1458 0.460375546603647 2236 1948547
SGTC_2091 4-phenylthiadiazole 200 µM 0.0994571542634601 0.445575274261956 no 1459 0.460387652559228 2159 270010
SGTC_508 roscovitine 141 µM 0.0989217101804229 0.445778498524254 no 1460 0.460600215608661 2233 160355 A CDKinase inhibitor.
SGTC_885 0865-0106 16.8 µM 0.0987518901559307 0.445842955570246 no 1461 0.46066763389595 2204 2793380
SGTC_17 0960-0276 49.807 µM 0.0986481572750493 0.445882329223036 no 1462 0.460708816245721 2240 6821114
SGTC_1102 cgs 12066b 26.1 µM 0.0981333397944958 0.44607774520836 no 1463 0.460913206978228 2146 6438352 A 5-HT1B full agonist.
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0979409652457921 0.446150770689019 no 1464 0.460989585388629 2238 88881 An O-methylated flavonoid and antioxidant.
SGTC_195 4234-0266 16.654 µM 0.0961041885227964 0.446848103730731 no 1465 0.461718912373814 2114 2303354
SGTC_2808 7946468 45.46 µM 0.0946569522068301 0.447397663486942 no 1466 0.462293655774452 2181 2970879
SGTC_1564 D-Arginine 115 µM 0.0945055979106142 0.447455143180246 no 1467 0.462353767930098 2113 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1860 st056228 74.6 µM 0.0920806998873476 0.44837619431429 no 1468 0.463316961278048 2124 688679
SGTC_475 α-linolenic acid 10 µM 0.0920059552130071 0.448404589096689 no 1469 0.463346654043924 2227 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_781 4335-2806 94.4 µM 0.091843844087116 0.448466174461313 no 1470 0.463411054353133 2225 845254
SGTC_2358 9037157 4 µM 0.0913759693518209 0.44864392515065 no 1471 0.463596927766869 2165 2388925
SGTC_1674 st016616 23.6 µM 0.0901039708568873 0.449127223194873 no 1472 0.464102296885126 2246 625830
SGTC_973 1325-0077 65.9 µM 0.0900062775904787 0.449164345052293 no 1473 0.464141113141565 2196 2835149
SGTC_2340 7987427 183.45 µM 0.0889273444684208 0.449574351669895 no 1474 0.464569825947824 2196 2239331
SGTC_2322 7413319 38.22 µM 0.0889131941542202 0.449579729305729 no 1475 0.464575448832887 2167 1840400
SGTC_2741 miltefosine 3.04 µM 0.0884289092320984 0.44976378082602 no 1476 0.464767892523564 2204 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_433 pimozide 108 µM 0.0872924252033651 0.450195741688256 no 1477 0.465219537425161 2224 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3052 9092717 49.47 µM 0.0861427318503475 0.450632783261658 no 1478 0.46567647737395 2178 25237534
SGTC_2820 7989630 71.43 µM 0.0857034603084108 0.450799782688599 no 1479 0.465851075661935 2260 2984098
SGTC_3342 9147791 14.508 µM 0.0850163044754269 0.451061038628232 no 1480 0.46612421427053 2244 1838168
SGTC_2031 5180455 200 µM 0.084939511250567 0.451090236652379 no 1481 0.466154739918963 2254 29949
SGTC_886 0866-0150 153 µM 0.0848745280686892 0.451114944514205 no 1482 0.466180571178324 2251 271463
SGTC_363 0455-0021 3.06 µM 0.0825981570549372 0.451980583625421 no 1483 0.467085533363184 2220 4597466
SGTC_2103 5378138 10 µM 0.0809198221816372 0.452618953084478 no 1484 0.467752857919043 2255 244142
SGTC_2237 6667747 47.222 µM 0.0806153060905791 0.452734791639888 no 1485 0.46787394666243 2111 729940 YDL015C TSC13
SGTC_1096 rimcazole 32.2 µM 0.0805620768242368 0.452755040577014 no 1486 0.467895113222103 2164 18528119 A dopamine reuptake inhibitor.
SGTC_1804 st050076 49.1 µM 0.0779088851319354 0.453764495437057 no 1487 0.468950265791558 2216 3895976
SGTC_2376 9072922 81.32 µM 0.0759336461569451 0.454516205279135 no 1488 0.469735944180757 2223 17087968
SGTC_2259 7964009 200 µM 0.0739414766935835 0.455274523324994 no 1489 0.470528476265014 2223 313134
SGTC_439 amiodarone 34.4 µM 0.0736836419147593 0.455372679941717 no 1490 0.470631057631671 2201 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3064 1327-0027 10 µM 0.0735192684486027 0.455435257651912 no 1491 0.47069645578033 2210 16000455 YPR107C YTH1
SGTC_123 0083-0120 66.675 µM 0.0732362241412451 0.455543016470003 no 1492 0.470809070537463 2194 16001701
SGTC_3020 9089140 49.47 µM 0.0724115717359184 0.455856991476619 no 1493 0.471137188028698 2210 17217859
SGTC_3257 9139206 32.98 µM 0.0723071096682495 0.455896765936621 no 1494 0.471178753406067 2264 4910041
SGTC_1913 st060213 96.1 µM 0.0720134899772264 0.456008565483203 no 1495 0.471295586138059 2260 688959
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0719733857494302 0.456023835964248 no 1496 0.471311544001274 2258 165506
SGTC_422 cantharidin 155 µM 0.0715045269641604 0.456202368069475 no 1497 0.47149811089315 2281 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1025 k007-0731 70 µM 0.070062677232523 0.456751451040472 no 1498 0.472071886462423 2241 6256118
SGTC_1058 3448-5425 97.3 µM 0.0696064027717157 0.456925226022352 no 1499 0.472253470314669 2272 7279705
SGTC_2332 7982454 138.89 µM 0.0695585344436416 0.456943457452457 no 1500 0.472272520840105 2275 2981748
SGTC_312 4092-0653 6.84 µM 0.069375754751065 0.457013072899976 no 1501 0.47234526365852 2246 1148278
SGTC_3234 9132280 49.47 µM 0.0690013691240088 0.457155669568891 no 1502 0.472494264847706 2193 17612295
SGTC_184 1494-0393 24.714 µM 0.0685987210272319 0.457309037054273 no 1503 0.472654518471425 2247 3090647
SGTC_1831 st055328 12 µM 0.067914548857746 0.457569650805933 no 1504 0.472926828590096 2275 1103068
SGTC_3153 9100258 49.47 µM 0.0674008740166693 0.457765330990384 no 1505 0.473131286704151 2230 25236848
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0659908759285902 0.458302510587356 no 1506 0.473692544787781 2277 65057 A dermal irritant. YDR527W RBA50
SGTC_1721 st082152 9.2685 µM 0.0656232749564503 0.45844257137794 no 1507 0.47383887915807 2290 5296051
SGTC_2583 asiatic acid 100 µM 0.0652327878713246 0.4585913577289 no 1508 0.473994327884378 2256 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1777 st045864 34.765 µM 0.0650678232076305 0.458654215560653 no 1509 0.474059999741279 2295 4691462
SGTC_3143 9086658 49.47 µM 0.0646047826303733 0.4588306572084 no 1510 0.474244338339628 2168 25236626
SGTC_1772 st048439 82.2 µM 0.0643607591517517 0.458923645639539 no 1511 0.474341487437998 2167 2927068 YDL195W SEC31
SGTC_2705 st078069 42.8 µM 0.0639519967504363 0.459079415087845 no 1512 0.47450422477975 2237 1530061
SGTC_315 k915-0449 187 µM 0.0629359475632048 0.459466633985215 no 1513 0.474908754777874 2210 20970215 YNL149C PGA2
SGTC_1247 0448-0043 5.84 µM 0.0619076140979743 0.459858573605006 no 1514 0.475318201978786 2226 3089013 YGL099W LSG1
SGTC_2016 5121758 140 µM 0.0612721802064551 0.460100782776168 no 1515 0.475571223070473 2304 2795203
SGTC_1821 st053465 65.6 µM 0.0602318718454452 0.460497350403392 no 1516 0.475985480862749 2233 675086
SGTC_180 1486-1293 102.781 µM 0.0597552668991421 0.46067904631041 no 1517 0.476175276857998 2308 4140536
SGTC_377 3970-0964 33.1 µM 0.0587557029626182 0.461060136277284 no 1518 0.476573345691754 2277 16481235
SGTC_1749 st037932 54.2 µM 0.056846647848872 0.461788074496445 no 1519 0.477333677190924 2213 594497
SGTC_157 1348-1695 65.819 µM 0.055719436698777 0.462217949533473 no 1520 0.47778265765457 2306 5380510
SGTC_2364 9055074 200 µM 0.0547395678560235 0.462591669751238 no 1521 0.478172973006365 2247 6470630
SGTC_1176 0848-0131 83.3 µM 0.0543626287939942 0.462735442446221 no 1522 0.478323126353321 2308 6769040
SGTC_140 0062-0056 502.533 µM 0.0540071973970857 0.462871016113331 no 1523 0.478464714959533 2306 3758964
SGTC_2021 4019055 173 µM 0.052768244222909 0.46334362876237 no 1524 0.478958281836993 2292 44827708 YER133W GLC7
SGTC_1275 0867-0008 21.1 µM 0.0516706405161864 0.463762365308952 no 1525 0.479395565725985 2262 3422836
SGTC_1770 st043884 66.3 µM 0.0506586175675905 0.464148488323856 no 1526 0.479798776339926 2319 670149
SGTC_3047 9092122 49.47 µM 0.0506009628157804 0.464170486697533 no 1527 0.479821747796973 2280 17173831
SGTC_1398 3558-0053 112 µM 0.0505343186686088 0.46419591514316 no 1528 0.479848300993896 2267 4532369
SGTC_1665 st014639 11.4 µM 0.0494105101686937 0.464624732481112 no 1529 0.480296076245227 2320 981133 YIL048W NEO1
SGTC_2248 tofa 1.1 µM 0.0485063520053354 0.46496976657291 no 1530 0.480656351117206 2285 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2456 5770359 74.46 µM 0.0480994892578458 0.465125037307453 no 1531 0.480818476624661 2315 3118787
SGTC_1299 1079-1439 3.74 µM 0.0466416226358567 0.465681445322946 no 1532 0.481399429022415 2301 323161
SGTC_1254 0550-0035 264 µM 0.0463227958870201 0.465803137421402 no 1533 0.481526485159468 2295 15121435
SGTC_3115 9123671 49.47 µM 0.045742581744489 0.46602460594675 no 1534 0.481757711993736 2340 3286988
SGTC_265 mycophenolic acid 32.932 µM 0.045549544993891 0.46609829067234 no 1535 0.481834642328737 2294 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_966 1300-0360 30.2 µM 0.0439489209353008 0.466709314950419 no 1536 0.482472559839899 2311 70588
SGTC_2898 9056270 58.44 µM 0.0432777862293317 0.466965538203698 no 1537 0.48274004932476 2321 19154699
SGTC_414 piperonyl butoxide 100 µM 0.0424729308748584 0.467272830860856 no 1538 0.483060845152163 2322 5794 A potent inhibitor of cytochrome P450.
SGTC_2834 9001755 58.44 µM 0.0422313370413385 0.467365074865821 no 1539 0.483157140745206 2206 2989575
SGTC_839 0122-0028 230 µM 0.0419932692690037 0.46745597428431 no 1540 0.483252031865508 2291 759448
SGTC_1506 4226-2149 212 µM 0.0411459689750505 0.467779505577004 no 1541 0.483589763834737 2251 991114
SGTC_2753 fluvastatin 17.09 µM 0.041049226985781 0.46781644668462 no 1542 0.483628325725018 2281 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2495 cafestol 54.53 µM 0.0408069159843737 0.46790897480467 no 1543 0.483724912897436 2271 16667697 An anti-infammatory.
SGTC_2217 6934799 96.0675 µM 0.0405924536212605 0.467990870177431 no 1544 0.483810400168836 2325 675606
SGTC_2280 7785178 200 µM 0.0391398543956842 0.468545600453195 no 1545 0.484389443043271 2311 2954328
SGTC_3278 9139605 49.47 µM 0.0390790113703533 0.468568837017252 no 1546 0.48441369734239 2298 7958859
SGTC_64 000l-0018 272.079 µM 0.0388985320315299 0.468637764523735 no 1547 0.484485643476967 2332 6811119
SGTC_1672 st016598 6.51 µM 0.0387496391703699 0.468694629433927 no 1548 0.484544998384506 2208 4665860 YNL267W PIK1
SGTC_252 miconazole 1.30953 nM 0.0386680713951975 0.468725781931782 no 1549 0.484577514848668 2343 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_938 3126-1755 342 µM 0.0386085363239305 0.46874851978429 no 1550 0.484601248183178 2329 1777771
SGTC_2366 9070441 60.58 µM 0.0359451901103361 0.469765817907494 no 1551 0.485663031317103 2345 6837235
SGTC_2505 galangin 7.89 µM 0.0351562962170898 0.470067183906727 no 1552 0.485977555618297 2333 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2007 4011539 71.82 µM 0.0346928400936852 0.470244237164655 no 1553 0.486162335134871 2328 45595301
SGTC_63 0099-0242 26.702 µM 0.033829563623639 0.470574048684058 no 1554 0.486506530535037 2351 3898502 YLR359W ADE13
SGTC_1198 1612-1005 86.7 µM 0.0323988813452467 0.471120679791038 no 1555 0.487076977289141 2326 6998509
SGTC_1968 st069590 43.6 µM 0.0321975700807859 0.471197600629876 no 1556 0.487157246985314 2337 6384066
SGTC_2889 9059656 51.95 µM 0.0316743815790732 0.471397515466753 no 1557 0.48736586258555 2323 3949838
SGTC_2298 7976326 193.81 µM 0.0302990285774248 0.471923083952489 no 1558 0.487914285650666 2320 2235818
SGTC_802 4112-3352 742 µM 0.0302737579238602 0.471932741176568 no 1559 0.487924362560165 2328 704594
SGTC_2605 digitonin 300 nM 0.0299940572683784 0.472039630367865 no 1560 0.48803589632638 2356 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1388 3346-4487 254 µM 0.0296342605542003 0.472177131682466 no 1561 0.488179370667042 2321 3345614
SGTC_2067 5224629 34.075 µM 0.0290787107542013 0.472389449266465 no 1562 0.488400907487136 2316 2835000
SGTC_1185 1319-0113 81.3 µM 0.0273472158653868 0.473051234443375 no 1563 0.489091399059933 2324 4672763
SGTC_1948 st076329 66.6 µM 0.0252990335082823 0.473834154904665 no 1564 0.489908222417134 2367 24208413
SGTC_216 k038-0035 28.382 µM 0.0222715791448337 0.474991587647685 no 1565 0.49111565990708 2357 4444231 YPR107C YTH1
SGTC_3030 9087619 49.47 µM 0.0213937400820986 0.475327236142202 no 1566 0.491465783557559 2359 25236973
SGTC_1581 himbacine 57.9 µM 0.0212937605577935 0.475365465194872 no 1567 0.491505660532837 2354 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_473 2-arachidonoylglycerol 10 µM 0.0196647435195537 0.475988382215548 no 1568 0.49215540796681 2345 5282280 An endocannabinoid.
SGTC_2402 5553605 200 µM 0.019353190966328 0.476107522992112 no 1569 0.492279675801949 2359 6758546
SGTC_3133 9127736 49.47 µM 0.0179447413000443 0.476646154569232 no 1570 0.492841468177543 2372 27243420
SGTC_2774 tamoxifen 10.92 µM 0.0177466302575354 0.476721921363836 no 1571 0.492920490464428 2379 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2995 9067767 71.4286 µM 0.0176689124546919 0.476751644464026 no 1572 0.492951490521265 2352 11673567
SGTC_1441 4106-0040 13 µM 0.0176436133499945 0.476761320110602 no 1573 0.492961581830711 2374 2904180
SGTC_2586 curcumin 80 µM 0.0174637499231194 0.47683010930115 no 1574 0.493033325902129 2371 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_875 0709-0210 25.7 µM 0.0174302489518167 0.476842921902738 no 1575 0.493046688822039 2377 6251364
SGTC_591 4299-0174 154 µM 0.0170443545173383 0.476990510738688 no 1576 0.493200615557363 2356 5509088
SGTC_1162 k048-0130 20.1 µM 0.0148376494697435 0.477834545171423 no 1577 0.494080851474728 2372 6797406
SGTC_270 tamoxifen 5.46 µM 0.0140082379457876 0.478151809623064 no 1578 0.494411704375988 2382 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2142 5622915 118.518 µM 0.0135138777536243 0.478340917663887 no 1579 0.494608906883702 2374 5322196
SGTC_2010 4012422 159 µM 0.0134762899463656 0.478355296361005 no 1580 0.494623900883849 2377 952393
SGTC_2136 5328288 199.296 µM 0.0112085974854738 0.479222822264612 no 1581 0.495528510186764 2370 262395
SGTC_2931 9014674 55.67 µM 0.0108420053734059 0.479363074685629 no 1582 0.495674750390561 2380 2996810
SGTC_366 0181-0206 4.31 µM 0.0104175359284799 0.479525473262015 no 1583 0.495844079630912 2384 274874
SGTC_578 3460-0051 92 µM 0.00994113127422432 0.479707745876182 no 1584 0.496034127741741 2375 2876744
SGTC_2903 5923464 63.88 µM 0.00978282161433393 0.47976831615754 no 1585 0.496097281087224 2379 2876576
SGTC_1270 0831-1170 17.3 µM 0.00945331877032909 0.479894387534961 no 1586 0.496228727622594 2388 6764716
SGTC_832 4083-0019 164 µM 0.0084299210232514 0.480285963428943 no 1587 0.496636987914701 2380 1990758
SGTC_858 0438-0351 2.77 µM 0.00804733505707396 0.480432354666009 no 1588 0.496789612451784 2388 2799119
SGTC_3158 9100007 49.47 µM 0.00679810693331893 0.48091037283124 no 1589 0.497287968606711 2392 19297233
SGTC_1895 st058434 18.3 µM 0.00633019146927014 0.4810894281705 no 1590 0.497474635845664 2392 5393175
SGTC_3215 9129942 49.47 µM 0.00618605636264835 0.481144584545597 no 1591 0.497532136307747 2392 17682944
SGTC_2879 9041815 71.43 µM 0.00599739208321285 0.481216781504434 no 1592 0.497607401068987 2390 4942971
SGTC_563 tetrahydrosecaminediol 614 µM 0.00522760863128851 0.481511364157992 no 1593 0.497914495390333 2396 334274 A psychoactive constituent of the cannabis plant.
SGTC_717 1532-0246 73.2 µM 0.00522148116395831 0.481513709073204 no 1594 0.49791693986276 2394 9561992
SGTC_660 4031-1742 102 µM 0.00502487882594304 0.481588946992195 no 1595 0.497995371818386 2395 6738706
SGTC_3106 9121286 49.47 µM 0.0047923004551729 0.481677953456855 no 1596 0.498088156045994 2382 15943471
SGTC_2156 5649887 115 µM 0.00371093648801158 0.482091797429835 no 1597 0.498519553932931 2394 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_727 3032-0951 202 µM 0.00367630400033288 0.482105051795772 no 1598 0.498533370202294 2391 3652836
SGTC_2919 7978188 46.38 µM 0.0026186323697111 0.482509847849364 no 1599 0.498955318024833 2398 2980291
SGTC_1981 st071826 47 µM 0.00252979371616973 0.48254384933872 no 1600 0.498990759402425 2380 11838600
SGTC_1730 st033808 45.1 µM 0.00244279291929989 0.482577147542629 no 1601 0.499025467591437 2392 1045166
SGTC_1260 0700-1617 7.75 µM 0.00234967990908681 0.482612785235908 no 1602 0.499062614201406 2398 2853078
SGTC_424 splitomicin 100 mM 0.00112043089592139 0.483083275898124 no 1603 0.499553012836871 2398 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_23 0213-0011 39.996 µM 0.00103792043469555 0.483114857332982 no 1604 0.499585929729252 2402 627608
SGTC_1656 st012921 11 µM 0.000194650896167626 0.483437630468861 no 1605 0.499922345528091 2404 6732821
SGTC_419 nsc-638432 893 µM -0.00106326339701623 0.483919134755741 no 1606 0.499575819355652 2410 368090
SGTC_97 0535-0701 19.132 µM -0.00115248635951252 0.483953288409915 no 1607 0.499540224565385 2408 2832013 YGL099W LSG1
SGTC_2564 betulinic acid 100 µM -0.0012211756717168 0.483979582069155 no 1608 0.49951282151384 2407 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_283 0987-0079 11.7 µM -0.00214945944458008 0.484334927646635 no 1609 0.499142490407856 2401 411556
SGTC_904 1141-0088 396 µM -0.00333106928227189 0.484787264006506 no 1610 0.498671098081943 2414 1378119
SGTC_3224 9130643 49.47 µM -0.00452003397894324 0.485242435665826 no 1611 0.498196773477149 2426 17644395
SGTC_1101 ebselen 5.29 µM -0.00579989847883567 0.485732427993732 no 1612 0.497686188247081 2420 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1950 st077106 7.18 µM -0.00585316306594166 0.485752820654979 no 1613 0.497664939111929 2438 13831864
SGTC_3008 9078912 71.4286 µM -0.00623026413984454 0.485897197087252 no 1614 0.497514500296163 2422 16648731
SGTC_3344 9148862 3.898 µM -0.00660334012121439 0.486040034296957 no 1615 0.497365667578406 2424 4905352
SGTC_3276 9139060 49.47 µM -0.00674869364319266 0.486095685354101 no 1616 0.497307681205153 2416 4870619
SGTC_82 0054-0107 293.755 µM -0.00726863574079865 0.486294756199436 no 1617 0.497100259415878 2444 3104697
SGTC_2728 chlorpromazine 9.18 µM -0.007402426733808 0.4863459814695 no 1618 0.497046885968102 2422 2726 A thorazine and dopamine antagonist.
SGTC_1397 3532-0190 20.1 µM -0.00839752552496469 0.486726987256119 no 1619 0.496649911391222 2415 5322280
SGTC_953 1188-0045 9.7 µM -0.00839896232906799 0.486727537391927 no 1620 0.49664933820953 2424 6144426
SGTC_2681 menadione 3.18 µM -0.00872237880037982 0.486851370489202 no 1621 0.496520318433207 2433 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2190 6049624 200 µM -0.00930156221374723 0.487073137481392 no 1622 0.496289267067416 2421 2265554
SGTC_2566 crystal violet carbinol 226 nM -0.00975082029712199 0.487245159345367 no 1623 0.496110047156791 2463 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1791 st048313 56.1 µM -0.00992194503441355 0.487310683992659 no 1624 0.496041781566524 2426 1204976
SGTC_2691 st077356 60.2 µM -0.0111913753854608 0.487796766761344 no 1625 0.495535380379706 2435 2839272
SGTC_1202 1988-0068 29.6 µM -0.0123677832005711 0.488247246090534 no 1626 0.495066094150176 2431 2850480
SGTC_295 k015-0027 31 µM -0.0125002776164254 0.488297982844031 no 1627 0.495013240611685 2450 3887424
SGTC_387 norethindrone acetate 66.7 µM -0.0136822868707369 0.488750623881822 no 1628 0.494541727577837 2445 541197
SGTC_3279 9140807 49.47 µM -0.0150929338891219 0.489290838847701 no 1629 0.493979019130409 2432 45595718
SGTC_183 3914-0051 30.55 µM -0.0153791124452447 0.489400434915177 no 1630 0.493864863655606 2425 1596232
SGTC_1122 capsaicin 818.572 nM -0.017569399331344 0.490239261706878 no 1631 0.492991184351958 2474 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_819 1013-0258 27.7 µM -0.0181322155182644 0.490454813785963 no 1632 0.492766688952592 2442 5753198
SGTC_732 3970-1727 52.7 µM -0.0185005821458397 0.490595895449895 no 1633 0.492619756580266 2441 1275699
SGTC_1634 st006576 41 µM -0.0186189972644887 0.49064124780564 no 1634 0.492572523918544 2449 3915356
SGTC_603 3794-0023 45.9 µM -0.0192609933144843 0.490887130942865 no 1635 0.492316450488635 2445 3802260
SGTC_1218 1348-1416 30.7 µM -0.0202874134559452 0.491280254854295 no 1636 0.491907048164612 2438 6787668
SGTC_1368 1852-0141 284 µM -0.0213136176835179 0.491673304537144 no 1637 0.491497740483268 2442 2838987
SGTC_505 gw-5074 63.9 µM -0.0219160195264494 0.491904036136961 no 1638 0.491257473055036 2510 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1485 3909-9022 254 µM -0.0220755790125391 0.491965150974484 no 1639 0.491193833426635 2433 714516
SGTC_3218 9131285 49.47 µM -0.0223515289631194 0.492070846396966 no 1640 0.491083772482118 2457 17156417
SGTC_2458 5808907 16.39 µM -0.0227115841217151 0.492208756959039 no 1641 0.490940167713471 2450 2731747
SGTC_1320 1313-0481 95.3 µM -0.0233512240060149 0.492453758084732 no 1642 0.490685055994155 2452 6813365 YLR208W SEC13
SGTC_1649 st011737 51.3 µM -0.0236051101960369 0.492551004851223 no 1643 0.490583797970607 2464 1761035
SGTC_2675 theaflavin digallate 100 µM -0.0240327013555671 0.492714787335603 no 1644 0.490413262162421 2470 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1050 3232-1156 69.3 µM -0.0243594754663194 0.492839954166447 no 1645 0.490282936309346 2477 700529
SGTC_2146 5545642 200 µM -0.0251073536710069 0.493126422408859 no 1646 0.48998466732561 2445 825326
SGTC_2582 agaric acid 100 µM -0.0264406715486741 0.493637146924647 no 1647 0.489452927137134 2444 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3007 9078383 71.4286 µM -0.0272813850124242 0.493959185804809 no 1648 0.489117651975434 2471 6496995
SGTC_1744 st037937 38.9 µM -0.0289926986902383 0.49461472375192 no 1649 0.488435206874588 2498 1016152
SGTC_2468 5987765 72.9 µM -0.0293447515519166 0.494749583420961 no 1650 0.488294817839074 2509 26772094
SGTC_2825 7998094 58.44 µM -0.0295566063050975 0.494830738176873 no 1651 0.488210336665884 2482 2987815
SGTC_3099 9120367 49.47 µM -0.0302037739692306 0.495078648647174 no 1652 0.487952269356944 2467 24824940
SGTC_3076 9116187 49.47 µM -0.0302474403184764 0.495095375981941 no 1653 0.48793485695969 2480 27241210
SGTC_2854 9024559 71.43 µM -0.0305498455527126 0.495211219049659 no 1654 0.487814270454909 2482 3163529
SGTC_544 k015-0020 52.4 µM -0.0322551414026285 0.495864477924526 no 1655 0.48713429127418 2491 3008304
SGTC_2864 9034755 47.6 µM -0.0323675939652559 0.495907556274759 no 1656 0.487089452604877 2459 4930451
SGTC_1133 3473-0247 50 µM -0.0331000691169568 0.496188154147879 no 1657 0.486797393817007 2533 711311
SGTC_249 wiskostatin 11.211 µM -0.0336341283363881 0.496392743692369 no 1658 0.486584453589583 2455 2775510 A n-wasp and actin depolymerizer.
SGTC_1470 k295-0292 231 µM -0.0336861983601354 0.496412690937213 no 1659 0.486563692420174 2549 5045612
SGTC_1998 st075797 76.8 µM -0.0347089375249086 0.496804488721495 no 1660 0.486155917054285 2448 24208315
SGTC_1132 3456-3614 2.5 µM -0.0351121832841198 0.496958967681865 no 1661 0.485995143273788 2505 3125502
SGTC_3283 9109332 35.8195 µM -0.0369851283271749 0.497676477681991 no 1662 0.485248431751869 2457 17027281
SGTC_147 4466-0538 29.23 µM -0.0375195221116863 0.497881201070442 no 1663 0.485035387355336 2576 6742687 YHR072W ERG7
SGTC_178 4092-0806 87.505 µM -0.0375517584604246 0.497893550660877 no 1664 0.485022535969363 2478 2169044
SGTC_1526 st051518 75 µM -0.0381596357942201 0.498126425913761 no 1665 0.484780201704586 2536 673993
SGTC_2360 9040895 200 µM -0.0392088450971618 0.498528375046744 no 1666 0.484361940846444 2490 4914414
SGTC_2438 5259590 200 µM -0.0394612629533779 0.498625075855866 no 1667 0.484261318565392 2525 1201127
SGTC_1891 st059073 26.2 µM -0.0398875020431636 0.498788367435238 no 1668 0.484091407549618 2491 688754
SGTC_2244 6635614 200 µM -0.0400531178018495 0.498851814649336 no 1669 0.484025389178644 2480 836499
SGTC_2529 gangaleoidin 93.61 µM -0.0406294470161676 0.499072605950361 no 1670 0.483795654104496 2505 4565183
SGTC_519 k048-0011 62.8 µM -0.0408938233018814 0.499173888411426 no 1671 0.483690270810617 2566 6836379
SGTC_1013 4112-3890 241 µM -0.0408990297879538 0.499175883014945 no 1672 0.483688195459447 2480 705171
SGTC_2986 9022445 71.43 µM -0.0414469530643791 0.49938579239134 no 1673 0.483469790900639 2464 6459286
SGTC_1689 st020265 53.493 µM -0.0421895528786928 0.499670282598871 no 1674 0.483173795370771 2491 5758320 YPR016C TIF6
SGTC_421 streptovitacin 30 mM -0.0422980310209882 0.499711840624609 no 1675 0.483130557450403 2645 91467 include heat shock
SGTC_1239 0337-0584 35.4 µM -0.0427496418343848 0.499884852961483 no 1676 0.482950553626134 2534 914301 YML130C ERO1
SGTC_854 0422-0053 192 µM -0.0430502079231154 0.5 no 1677 0.482830755395017 2485 3596728
SGTC_1121 fusaric acid 630.51 nM -0.0442227706599876 0.499550790641285 no 1678 0.482363415722307 2515 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3255 9139072 49.47 µM -0.0442981208600378 0.499521923956147 no 1679 0.48233338477121 2539 17646060
SGTC_1044 1222-0021 1.78 µM -0.0443474372406275 0.499503030836709 no 1680 0.482313729697645 2608 4306703
SGTC_643 k048-0106 28.4 µM -0.0448248102344358 0.499320149170882 no 1681 0.482123474628871 2561 6763920
SGTC_303 1348-1668 34.2 µM -0.0449596241309851 0.499268501971015 no 1682 0.482069745833 2506 5380509
SGTC_3210 9128157 49.47 µM -0.0452498960098127 0.499157298865382 no 1683 0.481954061844032 2602 17590849
SGTC_2239 6685329 187.64 µM -0.0457981652916798 0.498947257185724 no 1684 0.481735560581623 2616 805680
SGTC_276 colchicine 750 µM -0.0462734826245102 0.498765163594258 no 1685 0.481546137231293 2572 2833 A microtubule depolymerizer.
SGTC_1519 esterone 74 µM -0.0463777242610378 0.498725228761374 no 1686 0.481504595434673 2487 698 A steroid.
SGTC_1979 st071809 45.3 µM -0.0477618853895179 0.498194959832568 no 1687 0.480953006461226 2595 4976333
SGTC_3350 9150499 3.57 µM -0.049054475742857 0.49769977431697 no 1688 0.480437941396901 2509 4910996 YPR165W RHO1
SGTC_1829 berberine 14.4 µM -0.0493296786986533 0.497594345741606 no 1689 0.480328284060512 2609 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1932 st074806 40.9 µM -0.0510222712132709 0.496945927835668 no 1690 0.479653886898639 2688 17251235
SGTC_2015 5119600 184 µM -0.0516330734039687 0.496711936563451 no 1691 0.479410532856567 2529 2828786
SGTC_1837 st055472 66.5 µM -0.0516921710478782 0.496689296996632 no 1692 0.479386987749975 2614 676091
SGTC_1136 pergolide 1.05886 µM -0.0538019571138013 0.495881071930227 no 1693 0.478546475114321 2519 47811 A dopamine receptor agonist.
SGTC_1232 0279-0259 161 µM -0.0540181331531383 0.495798259269638 no 1694 0.478460358583289 2515 1560000
SGTC_209 4077-0173 175.592 µM -0.0540665444845605 0.495779713894151 no 1695 0.478441073438758 2578 15993494
SGTC_3202 9113761 49.47 µM -0.0552943040353699 0.495309387870315 no 1696 0.477951999973554 2614 4798415
SGTC_244 nsc-207895 1.295 µM -0.0562966568921695 0.494925414693819 no 1697 0.477552741013367 2485 42640
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0568105028938354 0.49472857654894 no 1698 0.477348073676301 2536 6728940
SGTC_1865 st057639 52.2 µM -0.0568864476288677 0.494699484631588 no 1699 0.477317825028063 2502 688818
SGTC_3125 9127534 49.47 µM -0.0574149246768299 0.494497043334426 no 1700 0.477107337220431 2496 1639235
SGTC_1812 st052057 4.327 µM -0.0578868842491394 0.494316253125776 no 1701 0.47691936522821 2499 3645418
SGTC_1959 st077091 55.8 µM -0.0583878028620124 0.494124371060563 no 1702 0.476719865052008 2495 821356 YKL052C ASK1
SGTC_1167 k781-0610 148 µM -0.0589803322430672 0.493897398299933 no 1703 0.476483886716437 2546 4525169
SGTC_2876 9059903 25.97 µM -0.0597420006918879 0.493605638481082 no 1704 0.47618055987064 2517 6916095
SGTC_2028 5153890 36.43 µM -0.0597996472424576 0.493583556901341 no 1705 0.47615760326777 2513 2830968 YPR165W RHO1
SGTC_1158 4092-0494 91.8 µM -0.0602063542963272 0.493427767843318 no 1706 0.475995642450577 2618 1148199
SGTC_960 1222-0186 7.7 µM -0.0602963955932722 0.493393277676699 no 1707 0.475959786312339 2578 3126296
SGTC_606 k015-0008 38.6 µM -0.0605395465843845 0.493300139347994 no 1708 0.475862959987154 2543 1970475
SGTC_982 1491-0518 27.5 µM -0.0607464258107364 0.49322089510794 no 1709 0.475780578737807 2558 3091256
SGTC_1864 st057645 30.4 µM -0.0623399066832577 0.492610527988725 no 1710 0.475146074661808 2512 688666
SGTC_1359 1582-0056 520 nM -0.0625989370277406 0.492511310569183 no 1711 0.475042937944077 2579 3661189
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0630627512590061 0.492333655127338 no 1712 0.474858267711332 2602 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1091 telmisartan 47.6 µM -0.0630854842203193 0.492324947726797 no 1713 0.474849216594055 2612 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_558 k064-0027 21.3 µM -0.0652652394133392 0.491490054231835 no 1714 0.473981409121884 2574 5088526
SGTC_842 0271-0008 11.1 µM -0.0654288703290035 0.491427381502546 no 1715 0.473916269061667 2635 1221709
SGTC_788 1182-0090 188 µM -0.0676380318615804 0.490581265784806 no 1716 0.473036889830176 2731 5715185
SGTC_2960 9079389 5.97 µM -0.0681937933047196 0.490368413951195 no 1717 0.472815683848444 2559 16457355
SGTC_2551 apiole 73.87 µM -0.0702234848542113 0.489591083369516 no 1718 0.472007891127172 2519 10659 A possible DNA adduct former.
SGTC_1360 1598-0022 39.8 µM -0.0704332914189149 0.48951073392669 no 1719 0.471924397157509 2606 761525
SGTC_3150 9097574 49.47 µM -0.0713158036356889 0.489172763667901 no 1720 0.471573208885959 2550 17217476
SGTC_2870 9038528 12.99 µM -0.0714821847274446 0.489109046591376 no 1721 0.471507001405918 2684 6463316
SGTC_323 4013-0906 34.3 µM -0.0714965553976743 0.489103543232074 no 1722 0.471501282969345 2637 2910086
SGTC_860 0443-0016 25.1 µM -0.0715003271323094 0.48910209881747 no 1723 0.471499782106062 2542 5337942
SGTC_1367 1812-0510 76.9 µM -0.0722376893522761 0.488819723088914 no 1724 0.471206375870731 2577 1142582 YDR527W RBA50
SGTC_3067 9117431 49.47 µM -0.0744756643379941 0.487962716772566 no 1725 0.470315952212499 2579 17150885
SGTC_942 3253-1115 227 µM -0.0749380341875404 0.487785664449774 no 1726 0.470132007357382 2618 46497897
SGTC_983 1491-0821 12.2 µM -0.0765733761161407 0.487159472997472 no 1727 0.469481469766029 2619 46495113
SGTC_2790 5423970 71.43 µM -0.0771945791596381 0.486921615336927 no 1728 0.46923437699225 2623 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2084 5306078 60.6385 µM -0.0772884233284302 0.486885682955888 no 1729 0.469197050102584 2600 679340
SGTC_801 0866-0028 10.1 µM -0.078296244736295 0.486499800829045 no 1730 0.468796202280468 2536 6849771
SGTC_2945 9067681 61.76 µM -0.0791705411295164 0.486165053975026 no 1731 0.468448487898119 2526 16456930
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0792979457301536 0.486116274656018 no 1732 0.46839782011396 2592 4213774
SGTC_1594 piperine 70.1 µM -0.0822951506147947 0.484968798220017 no 1733 0.467206005295325 2569 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3102 9121669 49.47 µM -0.0824682310269214 0.484902538293748 no 1734 0.467137190113232 2581 41905072
SGTC_3001 9076041 71.4286 µM -0.082706232699374 0.484811425410505 no 1735 0.467042564438741 2559 16004211
SGTC_896 0964-0007 44.5 µM -0.0831488918753661 0.484641966723145 no 1736 0.466866575158068 2532 6756758
SGTC_1553 gossypol 38.6 µM -0.0841761835934246 0.484248709875761 no 1737 0.466458176854939 2538 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_87 0100-0052 35.5 µM -0.0869956336597226 0.483169477972497 no 1738 0.465337491392533 2581 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_540 1187-0821 17.3 µM -0.087247969100902 0.483072894655775 no 1739 0.465237205435234 2576 847520
SGTC_2442 5158906 48.48 µM -0.0876531379455022 0.482917815267318 no 1740 0.465076183348409 2672 1893835
SGTC_2403 6032726 181.2 µM -0.0879878263617073 0.482789714387187 no 1741 0.464943175885099 2606 2881040
SGTC_2983 9022671 12.99 µM -0.0887282429120343 0.482506328742491 no 1742 0.46464894322753 2769 6405161
SGTC_2699 st077704 54.6 µM -0.0892010339398691 0.482325378203989 no 1743 0.464461071844974 2606 645852
SGTC_2999 9069765 71.4286 µM -0.0899367075646913 0.482043822292243 no 1744 0.464168755459098 2627 2097066
SGTC_2319 6033012 152.6 µM -0.0901643560865396 0.481956698797568 no 1745 0.464078304321923 2604 847246
SGTC_427 1354-0053 47.3 µM -0.0906730182146153 0.481762031546507 no 1746 0.463876205319726 2810 6813657
SGTC_3145 9085516 49.47 µM -0.0907126154803151 0.481746877679243 no 1747 0.463860473129579 2640 25236195
SGTC_1527 coumarin 137 µM -0.0911202617930089 0.481590873037701 no 1748 0.463698516516589 2799 323 A hepatotoxic, DNA x-linker.
SGTC_2408 sulbentine 18.36 µM -0.0917329505914553 0.481356404752868 no 1749 0.463455108485265 2702 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_127 0180-0333 59.125 µM -0.0922748194152175 0.481149043751604 no 1750 0.463239847097486 2549 771601
SGTC_3203 9113543 49.47 µM -0.0937117602710147 0.480599183677391 no 1751 0.46266906402314 2716 17018012
SGTC_681 1642-0006 26.6 µM -0.0942173587973724 0.48040571996954 no 1752 0.462468247892754 2558 4446530
SGTC_248 streptozotocin 5.23457 mM -0.0952464318093413 0.480011966749318 no 1753 0.462059545173208 2666 5300 DNA alkylating agent.
SGTC_775 4577-0580 57.3 µM -0.0954974582675174 0.479915919680565 no 1754 0.461959854521847 2774 2006902
SGTC_949 1165-0505 146 µM -0.0958153465311142 0.479794291801564 no 1755 0.461833614334941 2578 6244267
SGTC_51 1013-0126 23.419 µM -0.0976842734675132 0.479079256257647 no 1756 0.461091501890473 2581 1627850
SGTC_1738 st035555 74 µM -0.0981299939201093 0.478908737261472 no 1757 0.460914535377437 2668 5331140
SGTC_2853 9015042 58.44 µM -0.0991075280572503 0.478534776195556 no 1758 0.460526447496392 2578 6457456
SGTC_1389 3405-0187 19 µM -0.0991919115671422 0.478502495700599 no 1759 0.460492948411054 2633 799890
SGTC_782 0083-0095 30.5 µM -0.100683552105475 0.477931899452775 no 1760 0.459900834267962 2566 3591729 An indicator and reagent.
SGTC_360 0957-0399 1.01 µM -0.101060892305654 0.477787562883366 no 1761 0.459751061236198 2685 6752301 YPR165W RHO1
SGTC_1220 1838-0075 193 µM -0.101284748227441 0.477701937029908 no 1762 0.459662211540157 2618 5529645
SGTC_1972 st070201 17.4 µM -0.102532190448166 0.47722480397213 no 1763 0.459167131599865 2644 2829099
SGTC_3289 9119912 71.43 µM -0.103021427228644 0.477037685108974 no 1764 0.458972982483154 2663 17014829
SGTC_2629 bisabolol 100 µM -0.103683942807949 0.476784300214162 no 1765 0.458710084875078 2678 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_536 3852-0578 10.6 µM -0.104072616292965 0.476635652992364 no 1766 0.458555860930281 2745 2869208
SGTC_2206 7254556 146.969 µM -0.104782200978528 0.476364282468768 no 1767 0.458274316926815 2641 4398905
SGTC_2497 7-hydroxyflavone 100 µM -0.105292573186505 0.476169104680833 no 1768 0.458071827978505 2757 5281894
SGTC_3237 9133362 49.47 µM -0.105373970977581 0.476137976865939 no 1769 0.458039534605037 2596 43845137
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.106853165959487 0.475572334644768 no 1770 0.457452734268619 2636 6857784
SGTC_1510 1123-0200 71.5 µM -0.107684839790928 0.475254325208795 no 1771 0.45712284783547 2779 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_659 k018-0002 107 µM -0.109246546893284 0.474657213672418 no 1772 0.456503471066354 2637 6797879 YHR007C ERG11
SGTC_1776 st049249 45.9 µM -0.109306020156982 0.474634475459893 no 1773 0.456479885906947 2625 1822314
SGTC_2165 5727197 32.143 µM -0.111252633096874 0.473890279534843 no 1774 0.455708007731854 3017 1361712
SGTC_1569 carminic acid 40.6 µM -0.111397628843704 0.473834850842778 no 1775 0.455650520134098 2640 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1298 1079-1278 263 µM -0.11153497019859 0.473782348723896 no 1776 0.455596068189272 2629 2840950
SGTC_3144 9087057 49.47 µM -0.111662326558291 0.473733664022496 no 1777 0.455545575756654 2564 17249618
SGTC_1001 4048-4355 44.4 µM -0.112123263228037 0.473557464373968 no 1778 0.455362836169747 2610 21824233
SGTC_2001 4023502 57.655 µM -0.112398650074213 0.473452196271364 no 1779 0.455253662815477 2697 108941 YCR052W RSC6
SGTC_168 3970-0862 530.542 µM -0.112792967533516 0.473301469531968 no 1780 0.455097346929271 2673 3135186
SGTC_2524 avocatin b 10.57 µM -0.113414420372268 0.473063928700417 no 1781 0.454851003835779 2697 6710748
SGTC_1216 1165-0504 9.65 µM -0.11471698283597 0.472566075322292 no 1782 0.454334726220901 2609 6304004
SGTC_524 r073-0010 27.8 µM -0.115003538787671 0.472456556280596 no 1783 0.454221158554997 2592 2772106
SGTC_1446 4239-0190 62 µM -0.117123462032654 0.471646406401314 no 1784 0.453381108838985 2629 1340085
SGTC_3112 9123419 49.47 µM -0.117198727468978 0.471617645098347 no 1785 0.453351287651749 2602 17015854
SGTC_1703 st026983 48.3 µM -0.117311674609851 0.47157448470242 no 1786 0.45330653695544 2640 1104023
SGTC_1824 st053723 68.6 µM -0.118025104413707 0.471301870106267 no 1787 0.45302388322809 2655 675225
SGTC_813 k007-0158 173 µM -0.118392961958058 0.471161310246499 no 1788 0.452878151051683 2686 6523916
SGTC_873 0591-4978 488 µM -0.118815432907679 0.470999886816101 no 1789 0.452710790802835 2805 3305145
SGTC_746 1095-0025 46.6 µM -0.119668996880349 0.470673760082065 no 1790 0.452372680366538 2724 6749286
SGTC_2095 5432005 200 µM -0.12013889568951 0.47049423117032 no 1791 0.452186560603943 2658 783734
SGTC_2125 5246583 200 µM -0.120536168754515 0.470342454230223 no 1792 0.452029214987434 2622 835267
SGTC_1889 st059080 5.18 µM -0.120680922344621 0.470287152640663 no 1793 0.451971885152164 2607 176925 Isolated from Daphnopsis sellowiana.
SGTC_1269 0831-0796 3.05 µM -0.122011668663448 0.46977878196525 no 1794 0.451444888530409 2697 927758
SGTC_1736 st036774 51 µM -0.122659115855809 0.469531462453097 no 1795 0.451188520069645 2894 1272247
SGTC_701 4424-0219 185 µM -0.123626340665939 0.469162012442774 no 1796 0.450805567817601 2679 2911779
SGTC_2345 9052315 157.45 µM -0.124588364817325 0.468794575260084 no 1797 0.450424720075941 2725 6469265
SGTC_226 1,3-diallylurea 8.28947 mM -0.124894476369191 0.468677664039032 no 1798 0.450303545675233 2721 74537 YKL182W FAS1
SGTC_1267 0828-0272 9.49 µM -0.125113545181057 0.468593998150786 no 1799 0.450216830027107 2728 745334
SGTC_1908 st060353 56.5 µM -0.126650512998425 0.468007044732037 no 1800 0.449608507610418 2756 4227716
SGTC_214 4373-3496 70 µM -0.126963191151893 0.467887644385246 no 1801 0.449484765966935 2658 3779166
SGTC_2201 6605497 169.863 µM -0.127047487141027 0.467855455325103 no 1802 0.449451406867766 2671 670741
SGTC_1031 k035-0009 16 µM -0.128110699518963 0.467449477761035 no 1803 0.449030684415745 2835 5180959
SGTC_1370 2001-0092 44.6 µM -0.128212987835219 0.467410421716073 no 1804 0.448990211047116 2715 790957
SGTC_1660 st012960 28.1 µM -0.130474464742486 0.466547018346214 no 1805 0.448095527805973 2708 24207266
SGTC_2195 6536160 144.242 µM -0.130564920588339 0.466512486691641 no 1806 0.448059747214388 2643 3834386
SGTC_1494 4358-1428 177 µM -0.132318300740514 0.465843181307338 no 1807 0.44736626637406 2733 1564571
SGTC_2750 bromebric acid 70.15 µM -0.134397345860139 0.465049687470607 no 1808 0.446544190146048 2749 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1874 staurosporine 7.6 µM -0.135152885232102 0.464761360582552 no 1809 0.446245498674865 2758 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_260 nsc-65238 3.989 µM -0.135709564363322 0.464548934030174 no 1810 0.446025443204257 2745 3246252
SGTC_2130 NSC 7 2.4545 µM -0.136754531211101 0.464150206151221 no 1811 0.445612412359009 2726 21448
SGTC_2892 9047358 58.44 µM -0.138638344344132 0.463431491014023 no 1812 0.444867970741117 2709 6466771
SGTC_12 0849-0099 9.267 µM -0.140256394246409 0.462814265434521 no 1813 0.444228708019692 2620 6071388
SGTC_313 3474-0040 5.03 µM -0.140468521647506 0.462733353362516 no 1814 0.444144910978583 2643 1043375 YIL048W NEO1
SGTC_1192 1488-0095 21.4 µM -0.141189742463625 0.462458268580331 no 1815 0.443860024614734 2727 915875
SGTC_2859 9028643 45.46 µM -0.141723377485657 0.462254743473041 no 1816 0.4436492543807 2761 17151580
SGTC_1384 3089-0840 101 µM -0.141755431349769 0.462242518640994 no 1817 0.443636594548293 2696 1069836
SGTC_1137 ixabepilone 100 µM -0.141980890773822 0.462156533024406 no 1818 0.443547549857965 2636 154225 A novel microtubule stabilizer.
SGTC_2124 5246320 200 µM -0.142636327378339 0.461906572957296 no 1819 0.44328870285513 2760 579342
SGTC_2470 5664817 21.68 µM -0.143132107589734 0.461717510114344 no 1820 0.443092923905789 2660 2859561
SGTC_713 1488-1073 324 µM -0.143379641356927 0.461623117815553 no 1821 0.442995180342566 2636 3312542
SGTC_780 0109-0199 192 µM -0.145087252216131 0.460972012036977 no 1822 0.442320991523649 2855 610414
SGTC_843 0310-0051 143 µM -0.145132094439283 0.460954915263218 no 1823 0.442303289424391 2672 2065037
SGTC_3141 9094609 49.47 µM -0.14643686947298 0.460457481836188 no 1824 0.441788261687784 2662 25236309 YDL196W YDL196W
SGTC_933 2914-0560 114 µM -0.146667509196613 0.460369558985671 no 1825 0.441697232559385 2841 463887
SGTC_173 1273-0061 2.693 µM -0.14680248214629 0.460318106447196 no 1826 0.441643962721792 2779 2847414 YPL266W DIM1
SGTC_2047 4141938 200 µM -0.146853259893154 0.460298749822249 no 1827 0.441623922517716 2675 3807862
SGTC_1390 3413-2614 145 µM -0.148454033983579 0.459688578551007 no 1828 0.440992229742763 2727 3421432
SGTC_381 3461-2219 42.7 µM -0.148702929662407 0.459593714821936 no 1829 0.440894024703558 2752 2883159
SGTC_3080 9117754 49.47 µM -0.149652401254324 0.459231855802325 no 1830 0.440519431722396 2837 9550191
SGTC_3182 9108849 49.47 µM -0.149655069863493 0.459230838799554 no 1831 0.440518378956621 2739 17133045
SGTC_1903 st060211 78.3 µM -0.149687049577204 0.459218651401553 no 1832 0.440505762998767 2826 688960
SGTC_1939 st074455 53.6 µM -0.151615082939283 0.458483953386229 no 1833 0.439745268237952 2905 1644229
SGTC_2963 9082507 9 µM -0.152169603969107 0.458272673282797 no 1834 0.439526583630302 2803 16459611
SGTC_2398 5228213 48.84 µM -0.152490004556221 0.458150601642846 no 1835 0.439400236726877 2764 80771 YMR134W ERG29
SGTC_2191 5911152 200 µM -0.152956137940369 0.457973013306206 no 1836 0.439216432516884 2700 2875902
SGTC_876 0720-0963 56.8 µM -0.153022271777718 0.457947818196454 no 1837 0.439190355896411 2876 765861
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.153862287040996 0.457627811027468 no 1838 0.438859160264492 2681 2724 A muscle relaxant with antifungal properties.
SGTC_552 k242-0005 476 µM -0.153862482698956 0.457627736493978 no 1839 0.43885908312675 2777 4088318
SGTC_2473 5854593 8.94 µM -0.154323030362222 0.457452300670862 no 1840 0.438677519614365 2647 2872951
SGTC_1427 4048-4900 550 nM -0.154619402896275 0.457339408248479 no 1841 0.438560686328813 2801 24132586
SGTC_61 0978-8327 98.565 µM -0.155070799397864 0.45716747165668 no 1842 0.438382751194474 2661 6150059 YHR072W ERG7
SGTC_3199 9111318 49.47 µM -0.155274330602229 0.457089949392763 no 1843 0.43830252568527 2787 8548020
SGTC_1424 4048-1941 275 µM -0.155517741980601 0.456997239458034 no 1844 0.438206584012892 2786 X1424
SGTC_155 k072-0202 43.6 µM -0.156384715498738 0.4566670477379 no 1845 0.437864892105512 2648 5857737
SGTC_2639 lactacystin 53 µM -0.156601409037916 0.456584523454275 no 1846 0.437779495998098 2782 3870 A proteasome inhibitor.
SGTC_670 4204-0025 119 µM -0.157079226802195 0.45640256078952 no 1847 0.43759120447278 2800 719039
SGTC_2687 chenodiol 100 µM -0.157808618956087 0.456124811153545 no 1848 0.437303803409832 2775 5702181 A cholesterol synthesis inhibitor.
SGTC_3077 9117319 49.47 µM -0.15873203812343 0.455773207569295 no 1849 0.436939997703644 2665 17154678
SGTC_3328 9140624 29.0385 µM -0.158779107979943 0.455755286048575 no 1850 0.436921454699037 2855 4904392
SGTC_1784 st039334 36.3 µM -0.159288775059058 0.455561239622901 no 1851 0.436720682026527 2931 3496984
SGTC_1386 3228-0095 33.8 µM -0.159626227117734 0.455432766748971 no 1852 0.436587758820031 2813 870181
SGTC_954 1189-0853 2.85 µM -0.16037610490329 0.455147294146973 no 1853 0.436292405747102 2644 2828194
SGTC_816 0325-0417 81.3 µM -0.160559419187087 0.455077511351583 no 1854 0.436220209462 2751 68101
SGTC_150 3970-0969 77.2 µM -0.16103951427272 0.454894758697348 no 1855 0.4360311394458 2808 6615640
SGTC_2828 7998861 71.43 µM -0.161131505561484 0.45485974244735 no 1856 0.435994913301336 2743 2988188
SGTC_1835 st008666 49.2 µM -0.16171609192725 0.454637229342731 no 1857 0.435764715910566 2708 690455
SGTC_3170 9103054 49.47 µM -0.162887045897212 0.454191568014194 no 1858 0.435303685242421 2756 16432970
SGTC_628 1636-0253 16 µM -0.166846338698333 0.452685104258445 no 1859 0.433745478334755 2793 4456143
SGTC_2620 irigenin 100 µM -0.167541712288623 0.452420592560326 no 1860 0.433471914835619 2852 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2883 9059145 45.46 µM -0.168318658707455 0.452125076526535 no 1861 0.433166297874221 2674 16476510
SGTC_2842 9000675 19.48 µM -0.168509131713449 0.45205263306621 no 1862 0.433091380162887 2768 2989072
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.169320178041343 0.451744182045857 no 1863 0.43277240267266 2694 364106
SGTC_1965 Pectolinarigenin 58.4 µM -0.169600392885232 0.451637619611625 no 1864 0.432662206774087 2728 5320438 An anti-inflammatory.
SGTC_1024 4507-0395 26 µM -0.170079210252973 0.451455539024421 no 1865 0.432473921557079 2874 4201836
SGTC_626 0214-0009 33 µM -0.170257535865937 0.451387729488287 no 1866 0.432403802543425 2818 3437874
SGTC_2916 7875993 68.79 µM -0.171087458689118 0.451072164342222 no 1867 0.432077498498253 2716 1299250
SGTC_2288 7946289 167.31 µM -0.171252398722231 0.451009452156719 no 1868 0.432012653883507 2848 1246052
SGTC_768 0384-0033 77.3 µM -0.172340066482876 0.450595938477213 no 1869 0.431585093528414 2720 3965305 YMR134W ERG29
SGTC_1840 st055363 71 µM -0.173090052208533 0.450310837249102 no 1870 0.431290322060203 2756 676033
SGTC_2585 alliin 100 µM -0.17420886650593 0.449885576412485 no 1871 0.430850658811814 2888 87310 A garlic compound which reacts with lipids.
SGTC_1579 chlormadinone acetate 49.4 µM -0.175147260421857 0.449528937637261 no 1872 0.430481961862086 2880 45114258 A steroidal progestin.
SGTC_1055 3448-0672 86 µM -0.175283438419859 0.449477186254946 no 1873 0.430428462266456 2865 748378
SGTC_3259 9138485 49.47 µM -0.175794260874288 0.449283067346356 no 1874 0.430227789291076 2983 17646153
SGTC_1906 st060206 94.7 µM -0.176024733487903 0.449195488847362 no 1875 0.430137255656768 2843 5133468
SGTC_3231 9132313 49.47 µM -0.177833410758949 0.448508286331799 no 1876 0.429426903775912 2772 4905967
SGTC_403 arphamenine a 50 µM -0.177971721714823 0.448455741753585 no 1877 0.429372591989836 2712 5487158 An arginine aminopeptidase inhibitor.
SGTC_2164 5685496 200 µM -0.178248417446034 0.448350627267751 no 1878 0.429263943443809 2742 759046
SGTC_2314 7727897 200 µM -0.17833221242431 0.448318794943558 no 1879 0.429231041200902 2743 900724
SGTC_1022 4477-0945 21.3 µM -0.178796504972119 0.448142423930988 no 1880 0.429048744845802 2737 4648966
SGTC_2970 9090938 41.86 µM -0.179645795573374 0.447819830088716 no 1881 0.428715324917455 2949 17217104
SGTC_346 4513-0042 7.16 µM -0.179693189263482 0.447801829123154 no 1882 0.428696720296223 2729 2827372
SGTC_1559 coumarin 343 70.1 µM -0.182975451052033 0.446555431329041 no 1883 0.427408640319775 2865 108770 A hepatotoxic, DNA x-linker.
SGTC_890 0929-0006 47.2 µM -0.183290934396564 0.446435658089969 no 1884 0.427284873603972 2747 1378169
SGTC_993 3909-8757 62.7 µM -0.183645174357324 0.446301176727573 no 1885 0.427145910878235 2781 4288324 YLR208W SEC13
SGTC_2144 5628481 200 µM -0.184839802059248 0.445847701635012 no 1886 0.426677344098284 2738 2818399
SGTC_1763 st044482 94.5 µM -0.185132483697907 0.445736611832328 no 1887 0.426562561833084 2863 88505
SGTC_1420 4'-methoxyflavone 42 µM -0.185890779498359 0.445448814055831 no 1888 0.426265206536532 2744 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2114 5491910 81.25 µM -0.186115633896879 0.445363480059508 no 1889 0.426177041017723 2849 2849228
SGTC_1591 genipin 88.4 µM -0.186808280304417 0.445100631276685 no 1890 0.425905477231638 2889 442424 A DNA cross-linking agent.
SGTC_629 3448-6466 76.7 µM -0.187343186998911 0.444897658827085 no 1891 0.425695782016687 2768 573744
SGTC_1480 1070-0044 41.2 µM -0.187537065199071 0.444824094545457 no 1892 0.425619782673915 2830 3124987
SGTC_2594 a-mangostin 100 µM -0.187740217241303 0.444747013477329 no 1893 0.425540150993367 2897 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_477 mead ethanolamide 10 µM -0.188449998292565 0.44447772085765 no 1894 0.425261954380085 2721 16061185
SGTC_2321 7390090 138.78 µM -0.189445831549737 0.444099942578432 no 1895 0.424871703193188 2828 649046
SGTC_700 3453-2283 142 µM -0.189891128229885 0.443931031699604 no 1896 0.424697222315937 2919 565664
SGTC_2 0422-0095 29 µM -0.189986949457146 0.443894685919507 no 1897 0.424659678552161 2706 6790840
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.190210144430024 0.443810028059698 no 1898 0.424572231067024 2874 5024745
SGTC_1873 rapamycin 2 nM -0.191946531173641 0.443151504379796 no 1899 0.423892044224289 2751 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1643 st009866 20.2 µM -0.192773890657111 0.44283778387927 no 1900 0.423568026085451 2823 3156273 YOR207C RET1
SGTC_200 k038-0079 37.545 µM -0.193133009865052 0.442701623187498 no 1901 0.423427400584741 2776 3436683
SGTC_1904 st060225 78 µM -0.193635055161538 0.442511283159696 no 1902 0.423230823800921 2747 66595
SGTC_164 4100-3994 89.624 µM -0.194444144289856 0.442204561794148 no 1903 0.422914063658367 2768 4615967
SGTC_2011 4012611 177 µM -0.194605250988028 0.442143491235891 no 1904 0.422850995980365 2748 2049887
SGTC_673 1082-0474 110 µM -0.195808474766269 0.441687429958058 no 1905 0.422380038288112 2763 3098046
SGTC_2152 5568786 200 µM -0.196004688239085 0.441613065930249 no 1906 0.422303248245023 2725 5399883
SGTC_1287 0971-0001 34.6 µM -0.196091840623137 0.441580036226769 no 1907 0.422269141262383 2748 4665869
SGTC_2415 st077333 57.7 µM -0.196361621111447 0.441477795248377 no 1908 0.422163566682552 2977 2766255
SGTC_2521 angolensin 13.4 µM -0.19726588536295 0.441135127106026 no 1909 0.421809737154278 2897 821428 A flavenoid.
SGTC_2246 7293507 91.5585 µM -0.197452216277008 0.441064523049159 no 1910 0.421736835570164 2934 887656
SGTC_78 0336-0123 156.75 µM -0.198376860118843 0.440714187006803 no 1911 0.421375110308549 2703 6765896
SGTC_224 benfluorex 43.875 µM -0.19860779926049 0.440626694271113 no 1912 0.421284776112554 2853 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2054 5233173 129 µM -0.19867048054338 0.440602947575663 no 1913 0.421260258405405 2916 6889
SGTC_1790 st045711 43.5 µM -0.200841903918468 0.43978044004554 no 1914 0.420411097939075 2900 585119
SGTC_565 1418-0001 44.5 µM -0.201356786362213 0.439585447111462 no 1915 0.420209801308753 2924 2862145
SGTC_1353 1498-1206 8.11 µM -0.201476379862306 0.43954015753381 no 1916 0.420163048438986 2755 6756808
SGTC_2644 guaiazulene 100 µM -0.201776618857093 0.439426461721752 no 1917 0.420045680515331 2867 3515 A coloring agent.
SGTC_1743 st037606 46.3785 µM -0.202315245860129 0.439222504627095 no 1918 0.419835140971842 2778 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_570 0987-0065 62.6 µM -0.203445608477638 0.438794532792559 no 1919 0.419393377351878 2720 3104428
SGTC_2518 prenyletin 46.28 µM -0.206056221446828 0.437806390762299 no 1920 0.418373497555159 2873 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2796 7949634 45.45 µM -0.207504472673756 0.437258380597875 no 1921 0.417807950000958 2746 2971588
SGTC_495 decylubiquinone 155 µM -0.208242560152555 0.436979138654867 no 1922 0.417519789362173 2838 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1745 st081495 74 µM -0.210188657692519 0.43624301900245 no 1923 0.416760215844214 2784 13842402 YBL026W LSM2
SGTC_509 pifithrin 175 µM -0.210565656834459 0.436100442925186 no 1924 0.416613106654471 2791 4817 A p53 inhibitor.
SGTC_1878 temozolomide 1 mM -0.210632963325994 0.436074989375406 no 1925 0.416586844153042 2805 5394 DNA alkylating agent.
SGTC_2200 6600604 21.907 µM -0.210764617176836 0.436025202107547 no 1926 0.416535474858469 2772 2904777
SGTC_2812 7970281 58.44 µM -0.211982217390977 0.435564792864991 no 1927 0.41606045376517 2918 2233435
SGTC_40 0327-0103 19.753 µM -0.212201718535988 0.435481802516367 no 1928 0.415974833036397 2824 409036
SGTC_1502 4534-4282 27.7 µM -0.212204930861325 0.435480588001651 no 1929 0.415973580035464 2810 3278949
SGTC_2210 7115885 190.385 µM -0.214090045105339 0.434767970087002 no 1930 0.415238419342951 2787 2927039
SGTC_254 nsc-64875 3.808 µM -0.214369556529445 0.434662326116196 no 1931 0.415129440100809 2935 56993
SGTC_3292 9120825 59.784 µM -0.214829697124999 0.434488421816152 no 1932 0.414950049233089 2874 24824900
SGTC_2214 7179297 48.276 µM -0.215060531414372 0.434401185697472 no 1933 0.414860062625501 2776 769744
SGTC_2262 9014885 67.46 µM -0.216422929429793 0.433886378016062 no 1934 0.414329047333883 2800 6457424
SGTC_699 0375-0592 111 µM -0.216856855030675 0.433722434578398 no 1935 0.414159951075208 2847 762578
SGTC_2703 st077852 53.4 µM -0.218165878104021 0.433227935708679 no 1936 0.413649935026166 2948 6281836
SGTC_33 0986-0033 35.816 µM -0.221994239311651 0.43178232983563 no 1937 0.412159183909518 2793 2848082
SGTC_1240 0356-0016 42.1 µM -0.223022336646158 0.431394270520926 no 1938 0.411759061077214 2859 4305613
SGTC_2941 9056145 11.23 µM -0.22374675751387 0.431120874802617 no 1939 0.411477180456482 2771 2119517
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.224331458428898 0.430900233316657 no 1940 0.411249699812711 2877 688761
SGTC_1333 1482-0047 286 µM -0.224745250587321 0.430744098620654 no 1941 0.411088730049908 2912 3811116
SGTC_3299 9121982 43.1275 µM -0.225365496049322 0.43051008392814 no 1942 0.410847475693624 2833 17594604 YPL160W CDC60
SGTC_685 1278-0033 54.9 µM -0.225542378720312 0.43044335168252 no 1943 0.410778680535688 2930 3590572
SGTC_3154 9100113 49.47 µM -0.229549245162067 0.428932223271914 no 1944 0.409221025070122 2831 25237525
SGTC_1089 terbinafine 2.25 µM -0.229894712824555 0.428801983861484 no 1945 0.409086792430554 2928 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2747 doxorubicin 7.63 µM -0.230354067508892 0.428628821678748 no 1946 0.408908325113733 2807 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1856 st057054 55.7 µM -0.231282774886461 0.428278770380166 no 1947 0.408547563798249 3062 1266018
SGTC_191 3914-0123 66.505 µM -0.231400647913284 0.428234345338756 no 1948 0.408501780929619 2813 3144412
SGTC_2177 5811945 192 µM -0.231839756082776 0.428068858330891 no 1949 0.40833123864277 2971 5343475
SGTC_2896 9052656 71.43 µM -0.232856656343166 0.427685667025442 no 1950 0.407936358256122 2921 6469436
SGTC_1336 1486-0901 104 µM -0.233055081826922 0.427610903700085 no 1951 0.407859317014825 2893 5006114
SGTC_2844 9010103 25.97 µM -0.235153631578914 0.426820365702713 no 1952 0.407044746776443 3018 2480525
SGTC_2325 6158266 200 µM -0.236843574976138 0.426183965943943 no 1953 0.406389072589944 2902 3623240
SGTC_734 2023-0417 80 µM -0.237010320385916 0.426121183260891 no 1954 0.406324391917361 2950 3935732
SGTC_1785 bathophenanthroline 24 µM -0.23804582244372 0.425731339860179 no 1955 0.40592277716552 2844 72812 An iron chelator.
SGTC_1319 1306-0155 43.7 µM -0.238934744951054 0.425396738270958 no 1956 0.405578091567519 2824 3122360
SGTC_596 1155-0152 116 µM -0.238963523389668 0.425385906601966 no 1957 0.405566933758983 2847 280313
SGTC_3314 9135860 59.4275 µM -0.239768505576732 0.425082949127998 no 1958 0.405254861878886 2956 25252478
SGTC_2278 7948257 134.34 µM -0.240177519015601 0.424929032624495 no 1959 0.405096320448393 2985 1247028
SGTC_1621 st003705 32.4 µM -0.240370683872684 0.424856346424151 no 1960 0.405021451468621 2994 24207032
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.240411706251555 0.42484091040033 no 1961 0.405005552007016 2900 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_72 0744-0168 198.391 µM -0.241529847334836 0.424420217376526 no 1962 0.404572243137422 2815 677577
SGTC_1926 methyl fluorone black 53.6 µM -0.24238223675971 0.42409956942064 no 1963 0.404241998545022 2833 72721 Reacts with homocysteine.
SGTC_3331 9141060 1.957 µM -0.243585628878635 0.423646968449784 no 1964 0.403775879795962 2837 4906567 YPR165W RHO1
SGTC_1995 st072814 61.1 µM -0.24622469294063 0.422654758475905 no 1965 0.402754150829539 2853 5769371
SGTC_353 1988-1175 58.3 µM -0.248004001406482 0.421986067607172 no 1966 0.40206565541497 2763 2788357
SGTC_3022 9087993 49.47 µM -0.248414505001008 0.421831826036708 no 1967 0.401906855942182 2878 17173644
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.24875407071702 0.421704247543599 no 1968 0.401775510359752 3053 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3191 9110352 49.47 µM -0.249010036559449 0.421608083853599 no 1969 0.401676508925889 2825 17122424
SGTC_849 0386-0493 241 µM -0.249045838290101 0.42159463389036 no 1970 0.401662662180094 2855 726119
SGTC_3241 9133421 49.47 µM -0.249220778938562 0.421528913654478 no 1971 0.401595003576294 2875 17018221
SGTC_1381 2324-0066 62.1 µM -0.249300465396214 0.421498978438746 no 1972 0.401564185676217 2964 10885928
SGTC_1807 st050092 58.9 µM -0.250098437165822 0.421199235397813 no 1973 0.401255612271948 2859 5008496
SGTC_2845 9003024 42.97 µM -0.250172629721502 0.421171368681619 no 1974 0.401226925348458 3079 2990173
SGTC_2881 9058953 51.95 µM -0.250472572518238 0.421058714225018 no 1975 0.401110956391844 2808 17122249
SGTC_2956 9076196 2.52 µM -0.251381934411192 0.420717209738061 no 1976 0.400759416804738 2969 16423868
SGTC_1457 k015-0032 57.3 µM -0.252421617606059 0.420326837106919 no 1977 0.400357596294228 2824 4302660
SGTC_1364 1653-0028 37.6 µM -0.253582891387586 0.419890903184765 no 1978 0.399908907691065 2923 5718652
SGTC_1520 flindersine 88 µM -0.253705513269174 0.419844877529354 no 1979 0.399861537210462 3134 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.253903734553643 0.419770478245331 no 1980 0.399784964781504 2918 71034 A hepatoprotective.
SGTC_2203 7227154 166.4 µM -0.254478836948671 0.419554638720766 no 1981 0.399562825861425 2848 896304
SGTC_2769 toremifene 3.73 µM -0.254754569016009 0.419451163330932 no 1982 0.399456333180955 3047 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1438 4092-1045 4 µM -0.255784251055764 0.419064798553964 no 1983 0.399058717654704 2857 1351342
SGTC_2040 5100729 123 µM -0.255822133203156 0.419050585625442 no 1984 0.399044091318019 2859 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1340 1486-1359 257 µM -0.255964266657069 0.418997259795776 no 1985 0.39898921470674 2865 4309068
SGTC_907 3448-6986 75.5 µM -0.256014889240933 0.418978267502719 no 1986 0.39896967020643 3038 590582
SGTC_2120 5538279 151.968 µM -0.258079817258158 0.418203720973161 no 1987 0.398172653790073 2896 2058197
SGTC_1691 st019933 84.6 µM -0.25889265140931 0.417898916831582 no 1988 0.397859034133456 2912 6176082
SGTC_1305 1181-0477 144 µM -0.259443589683635 0.417692348878665 no 1989 0.397646500515988 3006 6252086
SGTC_365 0121-0052 13.6 µM -0.260404632238254 0.417332071443363 no 1990 0.39727583508637 3008 3101739
SGTC_3214 9129694 49.47 µM -0.262552140897567 0.416527260583839 no 1991 0.396447896069475 3021 17158655
SGTC_469 w7 172 µM -0.262655006486142 0.416488718924334 no 1992 0.396408249504183 2881 45115570 A P450 inhibitor.
SGTC_88 0180-0332 8.668 µM -0.262682717519469 0.416478336296805 no 1993 0.396397569271178 2832 3101745
SGTC_2871 9038510 12.99 µM -0.262796543417196 0.416435689205875 no 1994 0.396353699939642 3060 4945164
SGTC_1779 st039427 55 µM -0.262955250315182 0.416376228215553 no 1995 0.396292535333611 3075 1124498
SGTC_510 ag-490 170 µM -0.263319304666689 0.416239839156034 no 1996 0.3961522408003 2942 5328779
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.263737876140237 0.416083038306029 no 1997 0.395990953788249 2856 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1204 4049-0315 18.3 µM -0.26396492432095 0.415997989486642 no 1998 0.395903473374198 3118 588402
SGTC_2722 naftopidil 47.16 µM -0.264675298903217 0.415731919322181 no 1999 0.395629803840222 2937 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2102 5377816 72.7585 µM -0.264792201855333 0.415688137124114 no 2000 0.395584772278818 3061 1379702
SGTC_1245 0418-0076 17.2 µM -0.265352020132583 0.41547848991348 no 2001 0.3953691470026 3056 6790114
SGTC_1385 3091-4834 14.1 µM -0.265479487755971 0.415430757726974 no 2002 0.395320054756435 2980 4072814
SGTC_186 3455-3465 67.277 µM -0.26645049893357 0.415067188863961 no 2003 0.394946138925503 2864 755278
SGTC_2476 5806916 10.51 µM -0.268180769952986 0.414419516135661 no 2004 0.394280088180989 2872 2870194
SGTC_2656 pseudo-anisatin 100 µM -0.269098451518173 0.414076105094982 no 2005 0.393926961004436 2896 6708809 A neurotoxin.
SGTC_3335 9143315 29.6265 µM -0.269746299086479 0.413833709767688 no 2006 0.393677719411955 2918 4899691
SGTC_2312 7706453 155.7 µM -0.271132641342129 0.413315113447164 no 2007 0.393144508674422 2923 976098
SGTC_398 bronopol 33.3 µM -0.271820374505891 0.413057905545873 no 2008 0.392880069140303 2861 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1993 st073995 70.8 µM -0.272368735020233 0.412852848876257 no 2009 0.39266925504602 2914 3098394
SGTC_1414 3917-0015 5.4 µM -0.272937262111799 0.412640276121588 no 2010 0.392450721268225 2970 6618702
SGTC_1814 st052110 31.539 µM -0.275430807565254 0.411708240784642 no 2011 0.391492639010484 3025 674163
SGTC_2168 5727979 200 µM -0.277046061341125 0.411104757982814 no 2012 0.390872368996214 2837 695210
SGTC_2155 5570423 76 µM -0.277820501547315 0.410815490121137 no 2013 0.390575076263724 2919 797402
SGTC_737 1950-0117 57.9 µM -0.279159163927871 0.410315589203697 no 2014 0.390061340386742 3038 5393513
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.279173929830353 0.410310075937023 no 2015 0.390055674773596 2907 115019
SGTC_3264 9137442 49.47 µM -0.279459594101526 0.410203418604327 no 2016 0.389946071221769 3136 17015726
SGTC_1178 0988-0033 191 µM -0.280719884026827 0.4097329485629 no 2017 0.389462628255512 3041 5392207
SGTC_1833 st055984 71 µM -0.28096603181615 0.409641075995049 no 2018 0.389368226732548 2930 676288
SGTC_2100 5377183 190 µM -0.28154119730904 0.409426419718447 no 2019 0.389147667239252 2985 2844202
SGTC_1619 st003326 88.7 µM -0.282213656644658 0.409175487049196 no 2020 0.388889843634212 3068 2849032
SGTC_830 4076-0286 57.8 µM -0.282668137356371 0.409005915619682 no 2021 0.388715621607225 2905 6866659
SGTC_3273 9137859 49.47 µM -0.282857945829748 0.408935101164526 no 2022 0.388642866469481 2961 2377234
SGTC_1625 st003711 30.1 µM -0.283204823884883 0.408805694283441 no 2023 0.388509915372088 3105 24207034 YER133W GLC7
SGTC_1173 0443-0020 122 µM -0.283387242885661 0.408737644747303 no 2024 0.388440003226735 2905 5331295
SGTC_2742 clothiapine 36.27 µM -0.283573161218132 0.408668292652211 no 2025 0.388368753679998 2962 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_688 0527-0193 473 µM -0.284794071543437 0.408212934324846 no 2026 0.387900957226186 2925 4007154
SGTC_122 0236-0016 402.397 µM -0.287307300415293 0.407275975561176 no 2027 0.386938516639418 2954 6808838
SGTC_3235 9132602 49.47 µM -0.287514497748428 0.407198753755446 no 2028 0.386859201375602 3022 4912240
SGTC_2216 7189485 200 µM -0.289351661591117 0.406514206576541 no 2029 0.38615614098747 3025 731273
SGTC_1828 st055811 49 µM -0.290759967769898 0.405989649676697 no 2030 0.38561745211517 3069 5877589
SGTC_300 r073-0011 5.04 µM -0.291358320504862 0.405766830086307 no 2031 0.385388643896802 2999 2735780
SGTC_1820 st053765 18.6 µM -0.291501351210085 0.40571357163543 no 2032 0.385333955305429 2975 3690829
SGTC_201 4262-0159 12.803 µM -0.291572173265692 0.405687201209792 no 2033 0.385306876939692 2991 1341029
SGTC_621 3584-0052 32.1 µM -0.292007739401285 0.405525028599914 no 2034 0.385140353277214 3026 2273927
SGTC_2171 5739187 198.077 µM -0.292662134901584 0.405281410612677 no 2035 0.384890207588763 2868 2262761
SGTC_2066 5222451 176 µM -0.294336489260397 0.404658250182412 no 2036 0.384250396250151 2909 2281147
SGTC_3256 9138902 49.47 µM -0.297419242778506 0.403511545774558 no 2037 0.383073227199154 2930 17228773
SGTC_1312 1218-2183 165 µM -0.301666383478986 0.401933079115672 no 2038 0.381453198581421 2939 6744073
SGTC_516 3992-2719 87.3 µM -0.302796661661427 0.401513274959724 no 2039 0.381022413837034 2869 5350887 YDR037W KRS1
SGTC_3027 9089541 49.47 µM -0.302918699463994 0.401467954874822 no 2040 0.380975910181053 3040 9943819
SGTC_1679 SEC14.276 6.7 µM -0.303852540625497 0.401121206569522 no 2041 0.380620118150001 3068 1005053 YMR079W SEC14
SGTC_1251 0490-5699 265 µM -0.30434315164637 0.400939067008737 no 2042 0.380433236542137 3123 3883818
SGTC_2968 9090663 33.37 µM -0.304918001392757 0.400725681179001 no 2043 0.380214302554898 3011 25236811
SGTC_2935 9038016 29.96 µM -0.305625004477054 0.400463280284005 no 2044 0.379945090027846 3099 6463195
SGTC_1568 digitonin 820 nM -0.306628687077685 0.400090845342353 no 2045 0.379563007845941 3111 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2950 9072895 21.46 µM -0.306948835425901 0.399972067487647 no 2046 0.379441158395802 3073 17332245
SGTC_3261 9137475 49.47 µM -0.307036551483013 0.399939525673064 no 2047 0.379407775482759 3002 17027690
SGTC_2159 5658611 73.75 µM -0.308379527352049 0.399441381416946 no 2048 0.378896779101544 3058 793844
SGTC_1525 8-methoxypsoralen 92.5 µM -0.309197890617779 0.399137909655333 no 2049 0.378585499192551 3189 4114 Related to psoralen; DNA damaging agent.
SGTC_939 1165-0479 45.3 µM -0.310011791579946 0.39883615308808 no 2050 0.378275994716716 3080 1377347
SGTC_1850 st056238 17 µM -0.31195582969029 0.398115639283428 no 2051 0.377537046055271 2923 5393177
SGTC_562 3772-2733 112 µM -0.312670764671913 0.397850751995632 no 2052 0.377265404535903 3076 2876874 YIL048W NEO1
SGTC_2355 9061122 103.12 µM -0.312735930754039 0.397826609948353 no 2053 0.377240647520597 3074 5302957
SGTC_978 1416-0512 87.4 µM -0.31380180724282 0.397431790794558 no 2054 0.376835785845501 3029 6814003
SGTC_2724 maprotiline 69.64 µM -0.313831397087782 0.397420831699281 no 2055 0.37682454839198 3070 4011 A tricyclic antidepressant.
SGTC_1556 plumbagin 1.48 µM -0.314815546994781 0.397056381461483 no 2056 0.376450853361651 2970 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_642 0335-0876 158 µM -0.314959919356899 0.397002925063334 no 2057 0.376396042951957 2962 6812350
SGTC_1108 betulinic acid 729.144 nM -0.315126491006904 0.396941251394032 no 2058 0.376332807764966 3007 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1497 4476-2978 41.3 µM -0.315393212156486 0.396842502430732 no 2059 0.376231559982297 3046 1528379
SGTC_3236 9132701 49.47 µM -0.315597517376843 0.396766866375753 no 2060 0.376154011148104 3027 24282524
SGTC_2000 st075254 36.4 µM -0.315967796679472 0.396629794777258 no 2061 0.376013475706377 2967 17234175
SGTC_1669 st015249 58.4 µM -0.316518007204545 0.396426139054481 no 2062 0.375804679717226 3062 722793
SGTC_1141 3253-0389 52.6 µM -0.319665256224228 0.395261756398863 no 2063 0.374611050179475 3070 5402031
SGTC_2250 alverine citrate 130 µM -0.320375453771521 0.394999134619609 no 2064 0.374341865387954 2928 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3206 9114350 49.47 µM -0.320675028457984 0.394888370108122 no 2065 0.374228336536176 3085 17087243
SGTC_695 3505-6186 243 µM -0.321946458856022 0.394418367057296 no 2066 0.373746628135695 3083 1819379
SGTC_1754 st042065 16.137 µM -0.322206597881889 0.394322221734135 no 2067 0.373648093213816 3033 1126236 YIL048W NEO1
SGTC_1127 asiatic acid 681.4 nM -0.323446584617869 0.393864021041917 no 2068 0.373178527212266 2963 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_274 sirtinol 40.1 µM -0.323530192954104 0.393833131315199 no 2069 0.373146872648641 3007 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2432 5630864 12.22 µM -0.326585845573329 0.392704657363868 no 2070 0.371990575305946 3120 5714970
SGTC_21 0849-0113 22.993 µM -0.327264183676223 0.392454264267689 no 2071 0.371734039741566 2984 1560156
SGTC_1484 3473-2379 286 µM -0.327412052555678 0.392399687736734 no 2072 0.37167812588249 3019 671917
SGTC_694 1315-0438 43.2 µM -0.329595936836079 0.39159389066935 no 2073 0.370852646569931 3018 6793154
SGTC_488 nitrendipine 139 µM -0.329619985627671 0.391585019866199 no 2074 0.370843559745384 2983 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2267 7931562 200 µM -0.329780048533191 0.391525979395293 no 2075 0.370783081887499 2941 934880
SGTC_1688 st021091 57.6 µM -0.330869461596186 0.391124207198846 no 2076 0.37037154504154 3115 3656366
SGTC_2811 7967822 32.47 µM -0.332304074029889 0.390595303792238 no 2077 0.36982983195056 3144 2232244
SGTC_2478 5763493 32.33 µM -0.332902890866007 0.390374595775483 no 2078 0.369603793598599 2988 1365576 YLR208W SEC13
SGTC_1792 st045773 43.6 µM -0.336087877235316 0.389201289410108 no 2079 0.368402299914138 2970 2919270
SGTC_1120 ficusin 1.78878 µM -0.336942396872754 0.38888666712725 no 2080 0.368080162017411 3139 6199 A DNA cross-linker.
SGTC_1845 st056753 3.01 µM -0.3370607243036 0.388843106346 no 2081 0.368035562097659 2945 5375839
SGTC_9 0092-0002 10.449 µM -0.341574030592972 0.387182636402129 no 2082 0.366335741760872 3060 759368
SGTC_1659 st012954 42.1 µM -0.342510880287336 0.3868382217585 no 2083 0.365983228665467 3126 24207262
SGTC_3011 9081274 71.4286 µM -0.343480683141198 0.386481786375393 no 2084 0.365618435257971 3016 6625322
SGTC_1244 0416-0015 52.5 µM -0.343525165019805 0.386465440073519 no 2085 0.365601706216468 3027 96201
SGTC_2417 cerulenin 830 nM -0.34368382439268 0.386407137207573 no 2086 0.365542038623796 3131 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2243 6634756 200 µM -0.343812755650231 0.386359760478169 no 2087 0.365493553384953 3240 885676
SGTC_401 neomycin 50 µM -0.345131908833346 0.385875125492365 no 2088 0.364997602901089 3047 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2038 4100038 30.985 µM -0.345745399842313 0.385649799694002 no 2089 0.364767030912231 3106 3596803
SGTC_1059 3448-6867 171 µM -0.345823756302863 0.385621023350055 no 2090 0.364737585256014 3036 3934407
SGTC_1079 idarubicin 2.36 µM -0.346021969886434 0.385548232389797 no 2091 0.364663101928695 3147 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.348271785554595 0.384722304509891 no 2092 0.363818040458476 3117 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2334 9017922 200 µM -0.348391145597637 0.384678500921982 no 2093 0.363773225653261 3143 3163164
SGTC_3088 9117578 49.47 µM -0.349140427448724 0.384403557847755 no 2094 0.36349194361095 3091 678341
SGTC_777 1315-0167 517 µM -0.34914207809768 0.384402952219257 no 2095 0.363491324034899 3092 4221767
SGTC_202 3594-0513 34.79 µM -0.349513807477422 0.384266570684532 no 2096 0.363351803391502 3031 708429
SGTC_2374 9071832 200 µM -0.349661416836814 0.384212419156143 no 2097 0.363296406413842 2992 17381698
SGTC_678 1218-2179 85.9 µM -0.351204636152066 0.383646413843361 no 2098 0.362717416125313 3083 6820081 YOR116C RPO31
SGTC_903 1134-0042 114 µM -0.35489043075199 0.382295584165991 no 2099 0.361335838816073 3046 701009
SGTC_318 1488-0629 67.2 µM -0.355769573196546 0.381973592601221 no 2100 0.361006568622419 3110 3662576
SGTC_1638 st008370 60.6 µM -0.35821926653377 0.381076807934465 no 2101 0.360089615025405 3061 24207134
SGTC_1408 3909-7976 48.8 µM -0.360189599288539 0.380355970690843 no 2102 0.359352676017056 3077 24152374
SGTC_2684 capsaicin 100 µM -0.360283750633428 0.380321536227803 no 2103 0.359317474831063 3142 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_291 SEC14.278 35.5 µM -0.360704886556302 0.380167523599904 no 2104 0.359160035682976 3163 1068044
SGTC_2444 5485484 36.41 µM -0.360996780535928 0.380060786885069 no 2105 0.359050926893341 3159 6790631
SGTC_1910 st062352 60.4 µM -0.363942579786836 0.378984110599525 no 2106 0.357950443875018 2971 2245730
SGTC_465 cgp-37157 41 µM -0.364503249535568 0.378779294375685 no 2107 0.357741123842125 3098 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1303 1160-0052 261 µM -0.366240704910577 0.378144807292359 no 2108 0.357092735434936 3087 3562476
SGTC_1716 st033144 30.6155 µM -0.367416247461196 0.377715706747231 no 2109 0.356654277044465 3215 674617
SGTC_2287 7945887 168.79 µM -0.368651150242208 0.377265100812105 no 2110 0.356193882173568 3139 1245853
SGTC_235 0330-0087 5 mM -0.369949617493154 0.376791480898441 no 2111 0.355710015292647 3082 46494818 YHR062C RPP1
SGTC_101 0490-5701 117.494 µM -0.370238543318372 0.376686119503922 no 2112 0.35560238020966 3133 4661669
SGTC_952 1185-0122 232 µM -0.370322626174448 0.376655459079013 no 2113 0.355571058536055 3012 678600
SGTC_163 TUB2.036 7.546 µM -0.373213444291933 0.375601810028137 no 2114 0.354494795403952 3167 15992207 YJR013W GPI14
SGTC_2954 9074818 52.69 µM -0.374078649648319 0.375286638785431 no 2115 0.354172901293887 3218 16648742
SGTC_809 3998-0021 90 µM -0.376839416016858 0.374281522660425 no 2116 0.353146473346741 3209 715485
SGTC_655 k060-0012 42 µM -0.3774257674463 0.374068158570727 no 2117 0.352928610378869 3067 5994525
SGTC_1463 k081-0032 34.1 µM -0.377432603858234 0.374065671135004 no 2118 0.352926070546469 3128 977755
SGTC_976 1348-1067 47.6 µM -0.37756475948564 0.374017587200553 no 2119 0.352876973981991 3064 5310671 YGL099W LSG1
SGTC_58 0957-0393 9 µM -0.378311841364248 0.373745803375043 no 2120 0.352599474919036 3196 6997992
SGTC_2697 mebhydrolin 72.4 µM -0.379167213918322 0.373434701144078 no 2121 0.352281848237546 3248 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2833 9001315 45.46 µM -0.379867804415671 0.37317995515927 no 2122 0.352021773712044 3029 2989378
SGTC_2575 plumbagin 510 nM -0.383369183197731 0.371907630245976 no 2123 0.350723024675478 3026 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_602 3130-1533 38.1 µM -0.383468674242746 0.37187149771896 no 2124 0.35068614634719 3183 720941
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.384526142643201 0.371487522847359 no 2125 0.35029426173048 3059 279621
SGTC_1418 3966-3099 2.4 µM -0.384990476014716 0.371318960215799 no 2126 0.350122235881862 3166 740335
SGTC_456 gingerol 170 µM -0.385093855091616 0.371281434827365 no 2127 0.35008394026979 3265 442793 A herb.
SGTC_340 k038-0059 454 µM -0.386153284735324 0.370896944913517 no 2128 0.349691574446037 3145 23733424
SGTC_2706 st078239 82.5 µM -0.386513883142124 0.370766105334875 no 2129 0.349558061354669 3114 15434492
SGTC_108 0509-0257 621.132 µM -0.386752248112084 0.370679625156778 no 2130 0.349469815926646 3125 536624
SGTC_3169 9102970 49.47 µM -0.387349775886215 0.370462867378481 no 2131 0.349248640100675 3162 17027839
SGTC_665 3914-0008 307 µM -0.388898102663645 0.369901391449092 no 2132 0.348675762882837 3076 1069549
SGTC_215 1287-0124 461.5 µM -0.389146122218728 0.369811476854702 no 2133 0.348584028252437 3117 5560863
SGTC_1087 pterostilbene 9.05 µM -0.389468134206596 0.369694748383576 no 2134 0.348464939359067 3213 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2849 9019321 12.99 µM -0.38948562619602 0.369688407928651 no 2135 0.348458470767646 3193 16489627
SGTC_3081 9117243 49.47 µM -0.389645455427806 0.369630475048161 no 2136 0.348399367467994 3251 45595589
SGTC_115 0527-0192 112.043 µM -0.390421528672961 0.369349215917752 no 2137 0.34811243545853 3186 4233931
SGTC_3244 9134489 49.47 µM -0.39071383605528 0.369243298003533 no 2138 0.348004385269298 3151 16584271
SGTC_2715 st079500 56.4 µM -0.392878909112562 0.368459090820034 no 2139 0.347204459858157 3055 28246688
SGTC_406 estrone 100 µM -0.393332900964417 0.368294720598234 no 2140 0.347036810510187 3267 5870 A steroid.
SGTC_3198 9112019 49.47 µM -0.394166764994485 0.367992878397518 no 2141 0.346728960608376 3092 45595555
SGTC_1034 k072-0165 12.7 µM -0.395540615633415 0.367495749580258 no 2142 0.34622197660903 3238 5835461
SGTC_2782 7736369 71.43 µM -0.395582588016648 0.367480565334089 no 2143 0.346206492119673 3126 2950836 YOL077C BRX1
SGTC_351 caspofungin 25 nM -0.396998023213938 0.366968628255938 no 2144 0.345684459165767 3126 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2700 st077718 96.8 µM -0.398239217793466 0.366519905387086 no 2145 0.345226929971855 3145 904970
SGTC_733 4069-0007 56.1 µM -0.399207837486295 0.366169851830274 no 2146 0.344870034383587 3176 5717425 YNL287W SEC21
SGTC_59 0330-0160 1.33 µM -0.399296694114225 0.366137745130204 no 2147 0.344837301361133 3162 4293482
SGTC_2972 9093619 59.92 µM -0.399617427490827 0.366021861851367 no 2148 0.344719159198549 3064 25236256
SGTC_182 3448-4371 550.524 µM -0.399798098071706 0.3659565896495 no 2149 0.344652615843173 3180 3491403
SGTC_292 k038-0015 474 µM -0.401371241632535 0.36538841253808 no 2150 0.34407340966608 3209 46368540
SGTC_1012 4112-3522 18 µM -0.402286279367844 0.365058061286309 no 2151 0.343736675576782 3261 3112398
SGTC_2934 9036370 36.88 µM -0.405332139807242 0.363959152921193 no 2152 0.342616692427219 3190 6462800
SGTC_1742 st038235 28.8875 µM -0.406083327591364 0.3636883052512 no 2153 0.342340687772498 3209 564103 YBR002C RER2
SGTC_2167 5876490 200 µM -0.407144085917751 0.36330595508761 no 2154 0.341951082771477 3289 686534
SGTC_2297 7971671 152.32 µM -0.409364465443679 0.362506060830521 no 2155 0.341136106550021 3298 909016
SGTC_1188 1403-0014 4.57 µM -0.409984930007904 0.362282644836902 no 2156 0.340908501186152 3139 9614867
SGTC_1107 amlodipine 47 µM -0.411331887499658 0.361797795825127 no 2157 0.340414595362911 3193 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_951 1171-0579 82.7 µM -0.41202270450879 0.361549216242219 no 2158 0.340161390898873 3139 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_153 4077-0274 519.67 µM -0.41224443825215 0.3614694412398 no 2159 0.340080134324556 3406 3121976
SGTC_3140 9094243 49.47 µM -0.413217627993167 0.361119379891074 no 2160 0.339723586974394 3221 19291112
SGTC_3177 9107506 49.47 µM -0.413524419538255 0.36100904948814 no 2161 0.339611217516611 3206 8897194
SGTC_3037 9091026 49.47 µM -0.413610202200918 0.360978201828358 no 2162 0.339579800193713 3227 25236398 YIL048W NEO1
SGTC_2936 9038235 15.59 µM -0.414163639174446 0.360779206253602 no 2163 0.339377134429304 3101 4749415
SGTC_10 0279-0212 42.575 µM -0.414777158576172 0.360558651295431 no 2164 0.339152521077776 3159 39851 YBR002C RER2
SGTC_853 0419-0306 21 µM -0.415620692573278 0.360255483800114 no 2165 0.338843791242692 3108 762713
SGTC_343 4130-2827 29.8 µM -0.418175110546923 0.359337958335157 no 2166 0.337909545987393 3167 1118244
SGTC_550 4123-0385 25.7 µM -0.418176264829697 0.359337543909309 no 2167 0.337909124048513 3137 5731123
SGTC_1344 1488-0097 29.1 µM -0.418275330963186 0.359301976494093 no 2168 0.337872911970876 3231 747966
SGTC_2846 9008642 19.48 µM -0.419086175741978 0.359010907190347 no 2169 0.337576576755313 3239 2992898
SGTC_2913 7966556 36.57 µM -0.419489547337241 0.358866139182587 no 2170 0.33742919613187 3267 2976516
SGTC_2528 xanthyletin 44.79 µM -0.421483322285767 0.358150881588428 no 2171 0.336701093519486 3109 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_133 0724-0033 378.92 µM -0.42346565863972 0.357440220747407 no 2172 0.335977774485097 3052 280309
SGTC_2696 st077691 74.316 µM -0.423566858383465 0.357403954218552 no 2173 0.335940864774342 3284 757133
SGTC_1973 st070275 50.2 µM -0.423584756272518 0.35739754036093 no 2174 0.335934337196084 3212 17118334
SGTC_958 1222-0007 33 µM -0.425472387688314 0.356721318402326 no 2175 0.335246173187678 3298 7312461
SGTC_2598 perillyl alcohol 100 µM -0.426404643519377 0.356387514496439 no 2176 0.334906509185031 3291 10819 An apoptosis inducer.
SGTC_2377 9073351 62.6 µM -0.427158638844809 0.356117619064389 no 2177 0.334631892478474 3132 7337946 YHR072W ERG7
SGTC_514 4466-0038 2.65 nM -0.427914909385193 0.355846981609173 no 2178 0.334356535937508 3155 5722064
SGTC_2515 chrysin 20.77 µM -0.428794247657472 0.355532394712384 no 2179 0.33403648272236 3229 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1297 1068-0111 14.1 µM -0.429149097942443 0.355405473409602 no 2180 0.333907361834269 3140 767057
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.429519358562796 0.355273057299612 no 2181 0.333772654482687 3125 15053
SGTC_2682 pyrogallin 40.03 µM -0.429625092468003 0.355235246945428 no 2182 0.333734190552355 3197 822798 An ATP competetive kinase inhibitor.
SGTC_900 1112-0045 141 µM -0.430935692447131 0.354766695931541 no 2183 0.333257565031445 3202 56211 YIL048W NEO1
SGTC_2224 6650123 117.647 µM -0.431532210581567 0.354553508138007 no 2184 0.333040718529977 3201 2908370
SGTC_2648 atorvastatin 78.68 µM -0.432331072579987 0.354268076651276 no 2185 0.332750403342357 3263 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2170 morpholine 200 µM -0.432705738311141 0.354134237663467 no 2186 0.332614280242632 3268 121171 Reacts with secondary amines.
SGTC_336 4111-0029 111 µM -0.434507951849659 0.353490698672191 no 2187 0.331959810836194 3190 3131175
SGTC_2489 cantharidin 73.42 µM -0.434517841418395 0.353487168432979 no 2188 0.331956220875417 3223 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2483 5729050 27.16 µM -0.434562135089793 0.353471357255517 no 2189 0.331940142250017 3342 2865180
SGTC_3149 9097855 49.47 µM -0.435555662423636 0.353116771792243 no 2190 0.331579572692647 3292 25236625 YMR079W SEC14
SGTC_2118 5526350 200 µM -0.438380413813565 0.352109328096948 no 2191 0.33055527108517 3260 743594
SGTC_399 oxolinic acid 75 µM -0.439777764143534 0.351611347972114 no 2192 0.330049036950597 3167 4628 A DNA gyrase inhibitor.
SGTC_264 promethazine 12.5 mM -0.439900356244832 0.351567671397205 no 2193 0.330004638931137 3308 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2390 9097792 176.6 µM -0.440114668597176 0.351491321841658 no 2194 0.32992702920928 3210 4497149
SGTC_2797 7859098 81.82 µM -0.440661006394519 0.351296714122798 no 2195 0.329729215011721 3154 972681
SGTC_1213 1315-0166 115 µM -0.440936682326944 0.351198532041771 no 2196 0.329629418256335 3234 768401
SGTC_2979 9012552 45.46 µM -0.44152468832953 0.350989146683388 no 2197 0.329416596210132 3275 17100905
SGTC_1811 st050069 61.5 µM -0.442717543570724 0.350564517219715 no 2198 0.3289850256789 3275 3877702
SGTC_1307 1187-1599 12.2 µM -0.444164926971136 0.350049532165309 no 2199 0.328461673831674 3152 1538471
SGTC_2688 kanamycin b 96.69 µM -0.446055710951003 0.349377198694545 no 2200 0.327778501888032 3370 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2069 5228469 200 µM -0.447517788326471 0.348857630337894 no 2201 0.327250623591057 3268 2835210
SGTC_2592 piperlongumine 83.33 µM -0.448355498674559 0.348560066573633 no 2202 0.326948326518092 3227 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2695 st077686 51.995 µM -0.448540564461969 0.348494341763904 no 2203 0.326881558778969 3221 2876092
SGTC_1509 1326-1131 80 µM -0.448645917318263 0.348456928471083 no 2204 0.32684355221918 3275 768313
SGTC_3021 9087658 49.47 µM -0.449368960211717 0.348200198621248 no 2205 0.32658275943626 3313 25237042
SGTC_1422 4031-0024 15.5 µM -0.449669000688685 0.3480936840708 no 2206 0.326474563349861 3238 782427
SGTC_1063 disulfiram 1.84 µM -0.450185275945531 0.347910434095507 no 2207 0.326288426098936 3220 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1455 4262-0120 131 µM -0.450338379190499 0.347856097496437 no 2208 0.32623323475618 3361 1529587
SGTC_1486 3970-0793 4.53 µM -0.452230914356107 0.347184691910367 no 2209 0.32555131976859 3283 2844330
SGTC_1467 k284-1082 293 µM -0.453625745131356 0.346690161202131 no 2210 0.325049110076776 3277 3334705
SGTC_1947 st076332 61.6 µM -0.453926787719091 0.346583462195955 no 2211 0.32494076115723 3311 24208416
SGTC_1097 itavastatin 7.23 µM -0.455880372187971 0.345891346194692 no 2212 0.324238002266899 3229 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2917 7979103 53.79 µM -0.459180632177747 0.344723299840156 no 2213 0.323052228798144 3324 2980565
SGTC_2296 7971656 126.45 µM -0.459251924772556 0.344698083845713 no 2214 0.323026633360109 3276 666570
SGTC_3173 9105693 49.47 µM -0.460107767551524 0.344395428497232 no 2215 0.322719434481138 3377 17096658
SGTC_851 0394-0702 453 µM -0.460207520677094 0.344360158849987 no 2216 0.322683636649348 3342 762646
SGTC_503 tyrphostin 8 294 µM -0.461797756858926 0.343798083030357 no 2217 0.322113179820725 3280 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2014 4013930 200 µM -0.46240016484541 0.343585249389398 no 2218 0.321897190565036 3333 64556
SGTC_3245 9134821 49.47 µM -0.463067870338681 0.343349403754201 no 2219 0.321657859628786 3217 17014901
SGTC_2904 7225135 42.03 µM -0.463992151632801 0.343023031571629 no 2220 0.32132668432314 3334 4446116
SGTC_2043 5101342 149 µM -0.465203763414433 0.342595377724154 no 2221 0.320892771957641 3238 678451
SGTC_2957 9076800 11.52 µM -0.467194565477759 0.341893136846473 no 2222 0.320180340725994 3234 16459615
SGTC_341 1486-1430 230 µM -0.467463744124823 0.341798227947892 no 2223 0.320084062857926 3172 2054753 YPL210C SRP72
SGTC_967 1306-0166 352 µM -0.470027838408141 0.340894663545829 no 2224 0.319167564263213 3347 4437607
SGTC_1949 st076024 69.1 µM -0.471781109331313 0.340277350801732 no 2225 0.318541517996634 3168 2921930
SGTC_2363 9053361 176 µM -0.472559852013224 0.340003298803404 no 2226 0.318263615689544 3400 6469797 YMR079W SEC14
SGTC_947 3447-0010 211 µM -0.474793279310532 0.339217789256797 no 2227 0.317467161868435 3320 748350
SGTC_3094 9117742 49.47 µM -0.475189433236889 0.339078532401656 no 2228 0.317325979011749 3241 17149698
SGTC_460 trequinsin 123 µM -0.475349688578772 0.339022205353297 no 2229 0.317268874146537 3342 5537 A vasodilator.
SGTC_354 2783-3500 4.88 µM -0.475610154836811 0.338930663536559 no 2230 0.317176069731754 3225 6740761
SGTC_2012 4023501 200 µM -0.475680121071697 0.33890607526829 no 2231 0.317151142643723 3267 3477460
SGTC_1714 st033236 13.627 µM -0.476136102671613 0.338745846246795 no 2232 0.316988708986972 3411 2916566
SGTC_3205 9113483 49.47 µM -0.476227669407186 0.33871367379775 no 2233 0.316956094553687 3362 17018033
SGTC_1887 st057648 70.8 µM -0.476467145582791 0.338629538160994 no 2234 0.31687080414765 3334 688672
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.478511143179822 0.337911744516016 no 2235 0.316143222541173 3400 5393153
SGTC_296 1222-0039 74.9 µM -0.479225134978286 0.33766114963639 no 2236 0.315889237447584 3263 5984176
SGTC_1990 st072050 59.8 µM -0.480141859597535 0.337339505666123 no 2237 0.315563262532097 3234 17233948
SGTC_339 3091-4833 71.4 µM -0.480693432982579 0.337146036685691 no 2238 0.315367199579594 3303 3240077
SGTC_1237 0330-0133 46.1 µM -0.482117806892518 0.336646624910565 no 2239 0.314861130413867 3248 X1237 YHR072W ERG7
SGTC_2411 st077133 39.94 µM -0.484692128084469 0.335744751385151 no 2240 0.313947375638232 3480 1403142 YNL221C POP1
SGTC_1989 st071868 50.2 µM -0.486393875879922 0.33514908899215 no 2241 0.313343965886404 3363 16414057
SGTC_881 0833-0569 170 µM -0.486558906372363 0.335091345421343 no 2242 0.31328547551871 3254 5418700
SGTC_948 3448-0295 75.3 µM -0.487855665783846 0.334637749727663 no 2243 0.312826039535139 3329 678569
SGTC_2733 amorolfine 100 µM -0.488849090394931 0.334290421174295 no 2244 0.312474270225694 3321 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_347 4534-1311 26.2 µM -0.488861830169415 0.334285967919372 no 2245 0.312469760210219 3310 2862016
SGTC_2421 5690543 90.72 µM -0.490662903438568 0.333656628305485 no 2246 0.311832444085944 3336 3397993
SGTC_3127 9126946 49.47 µM -0.491041930277953 0.333524246456133 no 2247 0.311698395752323 3278 27243249
SGTC_1026 k007-1105 30.6 µM -0.491199907875807 0.333469076095892 no 2248 0.311642532050685 3353 7066794
SGTC_156 3474-0145 5.642 µM -0.491805576770959 0.333257592330847 no 2249 0.311428396882757 3364 2265471
SGTC_616 4092-0450 108 µM -0.491842267061359 0.33324478274134 no 2250 0.311415427022357 3319 787165
SGTC_468 gf-109203x 121 µM -0.494033611210294 0.332480077410693 no 2251 0.310641221159754 3290 2396 A protein kinase C inhibitor.
SGTC_3031 9088762 49.47 µM -0.494562955769475 0.332295458334383 no 2252 0.310454328279123 3233 205253
SGTC_2359 9039622 200 µM -0.495978179484111 0.331802071798058 no 2253 0.309954903079669 3285 6463596
SGTC_1476 4112-3294 3.34 µM -0.498402167605263 0.330957679552984 no 2254 0.309100304642209 3396 704369
SGTC_3232 9132874 49.47 µM -0.498542879280229 0.330908689218962 no 2255 0.309050727148432 3298 3784940
SGTC_2053 5265679 138 µM -0.499104947218841 0.330713027906795 no 2256 0.308852726255886 3264 764595
SGTC_807 1315-0151 48 µM -0.501147223139523 0.330002481437155 no 2257 0.308133757143048 3458 4011080
SGTC_3124 9127567 49.47 µM -0.502248490894987 0.329619583682646 no 2258 0.307746368529237 3399 17592030
SGTC_474 dl-dihydrosphingosine 5 µM -0.502558219640084 0.329511926815827 no 2259 0.307637455050199 3414 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1156 4092-0367 4.88 µM -0.507139654303421 0.327921146017323 no 2260 0.306028416567467 3314 1357585
SGTC_500 h-89 112 µM -0.509462466397216 0.327115800415067 no 2261 0.305214050355945 3437 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_686 1319-0111 510 µM -0.510020290962106 0.326922515869807 no 2262 0.305018623175062 3435 4562600
SGTC_144 4161-2749 112.381 µM -0.510089613235345 0.326898499151375 no 2263 0.304994340826318 3309 797501 YMR168C CEP3
SGTC_3049 9092223 49.47 µM -0.510701684457631 0.32668647805164 no 2264 0.30477998052547 3360 8623917
SGTC_2752 diclazuril 33.15 µM -0.511049084104232 0.326566163914345 no 2265 0.304658343614153 3364 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3075 9116269 49.47 µM -0.511070021000724 0.326558913462302 no 2266 0.304651013555493 3439 17015205 YNL244C SUI1
SGTC_1496 4469-0713 57.4 µM -0.51259558498116 0.326030786765338 no 2267 0.304117121097032 3399 746691
SGTC_551 k048-0028 34.9 µM -0.513498275096737 0.325718453555127 no 2268 0.30380140853432 3420 6836383
SGTC_1349 flufenamic acid 69 µM -0.513740160200544 0.325634781424978 no 2269 0.303716834952146 3322 3371 A non-steroidal anti-inflammatory.
SGTC_1872 amphotericin b 148 nM -0.515461429967074 0.325039619108492 no 2270 0.303115307652286 3369 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_432 NS 1619 61.3 µM -0.516816686387261 0.324571326829228 no 2271 0.302642065313064 3414 4552 A K+/calcium channel activator.
SGTC_1915 st067105 30.6 µM -0.517160083907343 0.324452714007379 no 2272 0.302522206835306 3393 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_820 1582-0060 59.9 µM -0.518823804915583 0.323878301000708 no 2273 0.301941808008776 3300 3848840
SGTC_537 1334-0398 209 µM -0.518919859386114 0.323845150211929 no 2274 0.301908314122956 3419 5846986
SGTC_2256 7954252 200 µM -0.519264150781789 0.323726338162953 no 2275 0.301788274535053 3349 2972920
SGTC_651 3253-0966 34.4 µM -0.519364668603045 0.323691653700089 no 2276 0.301753232344632 3323 781462
SGTC_45 0kpi-0036 14.9 µM -0.519580315775099 0.323617248118433 no 2277 0.30167806031317 3403 2795021
SGTC_924 2046-0044 21.3 µM -0.519991875206766 0.323475265738928 no 2278 0.301534618982557 3370 3623589
SGTC_5 0352-0601 109.883 µM -0.520610347824446 0.323261949468766 no 2279 0.301319119663317 3334 762456
SGTC_2794 7785382 27.27 µM -0.521351329483336 0.323006455324991 no 2280 0.30106102490284 3420 2205081
SGTC_535 2293-4129 48.2 µM -0.521906046944285 0.322815240638683 no 2281 0.300867873931502 3434 396118 YIL048W NEO1
SGTC_376 3970-0862 59.1 µM -0.521924176032326 0.322808992215181 no 2282 0.300861562380182 3398 3135186
SGTC_2698 st077697 67.5 µM -0.521958596363214 0.322797128942825 no 2283 0.300849579278485 3320 3154499
SGTC_3275 9138069 49.47 µM -0.522134216427962 0.322736602737254 no 2284 0.300788442221523 3387 17617007
SGTC_2619 obliquin 87.91 µM -0.522832747707813 0.322495905400781 no 2285 0.300545324222868 3368 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1960 st011366 51.8 µM -0.523092471607542 0.322406429659567 no 2286 0.300454952116504 3381 3972846
SGTC_1170 0310-0127 64.8 µM -0.523613917005293 0.322226821060651 no 2287 0.300273549902585 3346 774975
SGTC_567 1080-0542 68.4 µM -0.52446753460852 0.321932887417499 no 2288 0.299976697389734 3396 5950415
SGTC_2163 5671233 125 µM -0.524765081768691 0.321830456559221 no 2289 0.299873254149089 3492 701023
SGTC_1077 5-fluorocytosine 377 nM -0.52545804210556 0.321591956874145 no 2290 0.299632406845007 3387 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_882 0843-0131 351 µM -0.528987403046807 0.320378381156935 no 2291 0.298407094226122 3443 5425421
SGTC_2635 hydroquinidine 100 µM -0.529892877198354 0.3200673412894 no 2292 0.298093102466575 3363 442912 An experimental heart treatment.
SGTC_518 1021-0119 62.6 µM -0.534956157200124 0.31833038654702 no 2293 0.296340087290445 3315 1097762
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.536289605831698 0.317873609506079 no 2294 0.295879206555658 3431 5377381
SGTC_944 3370-0224 231 µM -0.537045954684424 0.317614642879503 no 2295 0.295617935600343 3362 4580514
SGTC_1015 4130-4525 82 µM -0.537053995315489 0.317611890323237 no 2296 0.295615158637856 3307 1363237
SGTC_1160 4092-0570 10.5 µM -0.537533903079908 0.317447621342184 no 2297 0.295449436421036 3380 4994975
SGTC_389 tpck 16.7 µM -0.538891448990116 0.316983137863594 no 2298 0.29498087891421 3390 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_112 phenothiazine 287.218 µM -0.538967546969574 0.316957109513409 no 2299 0.294954623803125 3443 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_636 0kpi-0074 126 µM -0.539813576394458 0.316667796900634 no 2300 0.294662801666124 3387 616434
SGTC_1943 st076331 65.2 µM -0.540268729398401 0.31651219678658 no 2301 0.294505860205728 3461 24208415
SGTC_2474 5321570 43.32 µM -0.541552024239915 0.316073660265667 no 2302 0.294063574730602 3399 2841384
SGTC_2295 7971645 200 µM -0.54226092332385 0.315831521156344 no 2303 0.293819385534311 3348 2978226 YKL099C UTP11
SGTC_3288 9119690 36.221 µM -0.543085103698852 0.315550104673665 no 2304 0.293535604238964 3364 17595618 YKL019W RAM2
SGTC_383 2324-0395 7.37 µM -0.544814391838288 0.314959986754086 no 2305 0.292940589701637 3449 3146421
SGTC_962 1254-0300 21.5 µM -0.545342128552239 0.314779991048514 no 2306 0.292759117258218 3379 7340576
SGTC_921 1561-0023 372 µM -0.547508773223503 0.314041472772799 no 2307 0.292014622390615 3431 24050882
SGTC_3025 9087895 49.47 µM -0.548118363161996 0.313833823136441 no 2308 0.291805316221846 3455 17173641
SGTC_3005 9076496 71.4286 µM -0.548922127559345 0.313560120367887 no 2309 0.291529446038106 3439 21368410
SGTC_2290 7904846 200 µM -0.549383936055147 0.313402908918813 no 2310 0.291370997916967 3412 2962154
SGTC_3325 9138760 55.175 µM -0.549956631869135 0.313207995667806 no 2311 0.291174559799704 3328 43844959
SGTC_449 xestospongin c 11.1929 µM -0.550255737559452 0.313106217751679 no 2312 0.291071989332507 3431 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3227 9130768 49.47 µM -0.550862627359066 0.312899752636655 no 2313 0.290863924240154 3434 17720899
SGTC_675 1309-0189 238 µM -0.551169456429843 0.312795391102784 no 2314 0.290758757936169 3377 4246530
SGTC_548 1436-0017 110 µM -0.551936406001985 0.312534594774612 no 2315 0.290495962167875 3512 9677137
SGTC_2714 st079313 56.9 µM -0.552541199855985 0.312329004643507 no 2316 0.290288807589245 3419 2939799
SGTC_2381 9035592 200 µM -0.553197689184854 0.312105907565608 no 2317 0.290064024569097 3393 4749657
SGTC_1994 st072947 40.9 µM -0.554558869055005 0.311643552599674 no 2318 0.289598214490942 3471 5286565 YDL195W SEC31
SGTC_2153 5569715 200 µM -0.554767387409233 0.311572750908434 no 2319 0.289526888346682 3431 2054701
SGTC_1944 st076371 56.9 µM -0.556237763374942 0.311073687679487 no 2320 0.289024163369797 3328 24208455
SGTC_808 0711-0032 135 µM -0.556823833129087 0.310874865296949 no 2321 0.288823899267067 3440 4252555
SGTC_936 3005-4620 401 µM -0.557339503792759 0.310699971241733 no 2322 0.288647745061485 3497 777207
SGTC_56 0957-0365 83.25 µM -0.561576319635953 0.309264641530508 no 2323 0.287202359107329 3464 6752360
SGTC_1732 st034308 51.822 µM -0.562132002026136 0.309076605007158 no 2324 0.2870130429705 3380 830119
SGTC_1437 4092-1038 11.6 µM -0.562244064489922 0.309038690417816 no 2325 0.286974871430862 3417 3977136
SGTC_1718 roemerine 11.9335 µM -0.562570535076485 0.308928245775965 no 2326 0.286863680331612 3451 235224 An aporphine alkaloid with mutagenic activity.
SGTC_991 3996-0057 64.7 µM -0.564023857088574 0.308436798237422 no 2327 0.286368948036186 3422 715343
SGTC_1253 0550-0034 176 µM -0.564197620451129 0.308378062298632 no 2328 0.286309823536109 3454 5969915
SGTC_2663 amphotericin b 100 µM -0.565019154708852 0.308100431607529 no 2329 0.286030367839659 3451 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2642 cholecalciferol 100 µM -0.565553833665526 0.30791980024441 no 2330 0.285848559412583 3443 9821465 A vitamin D precursor, similar to steriods.
SGTC_605 1315-0399 119 µM -0.565563504568545 0.307916533537591 no 2331 0.285845271493552 3516 24020461
SGTC_979 1426-2828 121 µM -0.565728513777248 0.307860797892254 no 2332 0.285789174341547 3507 747872
SGTC_1302 1159-0335 255 µM -0.566078478613894 0.307742603912133 no 2333 0.285670216309083 3421 649284
SGTC_1622 st003707 19.4 µM -0.56648879703907 0.307604052059634 no 2334 0.285530773243235 3469 10140899
SGTC_2036 5160441 105 µM -0.567496421951825 0.307263924722637 no 2335 0.285188478428369 3431 134534 YIL048W NEO1
SGTC_210 3551-0445 56.827 µM -0.568145006855968 0.307045080248525 no 2336 0.284968254652564 3514 2865180 YOR207C RET1
SGTC_2352 9027995 87.8 µM -0.56928909779242 0.306659210489665 no 2337 0.284579982100893 3410 2997347
SGTC_927 2425-1185 123 µM -0.569415363632107 0.306616637682745 no 2338 0.284537146480519 3380 730375
SGTC_1631 benzylvanillin 81.9 µM -0.570484040956692 0.306256418373353 no 2339 0.284174721638424 3468 75506
SGTC_2058 5236698 133 µM -0.572444539228579 0.305596079655891 no 2340 0.283510424476895 3401 766665
SGTC_549 1661-1316 519 µM -0.572459526410352 0.305591034075905 no 2341 0.28350534907309 3521 2857282
SGTC_1236 0330-0013 258 µM -0.573241867387129 0.305327702683993 no 2342 0.283240470060256 3403 4617066
SGTC_2093 5331342 194.4 µM -0.574042408965669 0.305058349324189 no 2343 0.282969551768405 3499 33839
SGTC_229 benomyl 22.8748 µM -0.574689543705855 0.304840688983881 no 2344 0.282750640201474 3466 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2418 pentamidine 31.67 µM -0.575323738859118 0.304627447791906 no 2345 0.282536184787476 3488 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_130 0136-0219 337.655 µM -0.575799052724753 0.304467672205307 no 2346 0.282375506949182 3452 234244
SGTC_2655 perillic acid 100 µM -0.576250859199421 0.304315833153223 no 2347 0.282222816445498 3408 5702197 An apoptosis inducer.
SGTC_2029 5175081 200 µM -0.577724440817994 0.303820839612163 no 2348 0.281725087708444 3474 1380876
SGTC_288 1315-0019 35.1 µM -0.578422842405566 0.303586363764114 no 2349 0.281489337887175 3507 6811474
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.57942041095307 0.303251588164451 no 2350 0.281152767540915 3437 2374 Ca(2+)-ATPase inhibitor.
SGTC_3340 9146634 11.102 µM -0.57956175177907 0.303204168725621 no 2351 0.281105096186131 3487 4907387
SGTC_2942 9052777 62.25 µM -0.580006055146058 0.303055127826871 no 2352 0.280955267228342 3528 6469503
SGTC_1870 st057514 26.5 µM -0.580831292993907 0.302778390042135 no 2353 0.280677081167178 3427 5393161
SGTC_2129 girgensonine 121.053 µM -0.581536170606669 0.30254210388623 no 2354 0.280439573863138 3444 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1548 st061468 90.8 µM -0.58155953213343 0.302534274147192 no 2355 0.280431703902753 3454 390799
SGTC_11 0438-0307 1.3 µM -0.582129283535253 0.302343347084929 no 2356 0.280239800884926 3502 4011476
SGTC_850 0388-0143 75.9 µM -0.584067909460165 0.30169410731166 no 2357 0.279587312008257 3426 67273
SGTC_1964 st076914 61 µM -0.584309203109452 0.301613342709087 no 2358 0.279506150752773 3510 24208661
SGTC_27 0485-0001 32.618 µM -0.58490677690753 0.30141336767617 no 2359 0.279305200778349 3460 2054479
SGTC_1761 st044296 37 µM -0.584954305547829 0.301397465020827 no 2360 0.279289221031784 3480 1826700
SGTC_2406 ethylparaben 405.7 µM -0.585168037097938 0.301325957036031 no 2361 0.279217367198144 3250 8434 A possible steroid mimic.
SGTC_1615 st002656 86.5 µM -0.587433384705613 0.300568511656746 no 2362 0.278456338886802 3533 1584458
SGTC_2755 lomerizine 42.69 µM -0.589438049666654 0.299898946469348 no 2363 0.277783729143821 3461 3949 A calcium channel blocker.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.589674997622819 0.299819849649599 no 2364 0.277704280284097 3487 97141
SGTC_1005 4092-0690 4.4 µM -0.590457678872995 0.299558645938089 no 2365 0.277441925471644 3438 1529343
SGTC_566 0958-0068 16.5 µM -0.590824228761183 0.299436352948603 no 2366 0.277319099593495 3525 6815365
SGTC_2748 diazoxide 86.69 µM -0.592279643249388 0.298951002771691 no 2367 0.276831672575 3440 3019 A potassium channel activatior.
SGTC_2485 5633444 17.78 µM -0.593220187043233 0.298637541356695 no 2368 0.276516902193933 3472 5724239
SGTC_2305 7443522 69.23 µM -0.5933427336923 0.2985967104106 no 2369 0.276475902615399 3485 5415886
SGTC_266 formosanin C 406 nM -0.593816829378042 0.298438771823961 no 2370 0.276317315803554 3462 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_179 1273-0063 6.77 µM -0.593882929512594 0.298416754475078 no 2371 0.27629520860218 3427 3108139
SGTC_2379 9035213 200 µM -0.594002481654771 0.298376934630113 no 2372 0.276255226571904 3518 646551
SGTC_589 1227-0070 34.1 µM -0.595953177608435 0.297727548288069 no 2373 0.275603253315895 3529 2841384
SGTC_1560 lithocholic acid 53.1 µM -0.596267638054968 0.297622924838333 no 2374 0.275498223322892 3470 9903 A bile acid which acts as a detergent.
SGTC_131 0141-0277 33.849 µM -0.596290388304251 0.29761535630341 no 2375 0.275490625488648 3502 1547771
SGTC_2517 totarol 10 µM -0.597214488437191 0.297308001684371 no 2376 0.275182093619279 3465 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2862 9027634 71.43 µM -0.599861416084783 0.296428440348837 no 2377 0.274299299240018 3470 5012562
SGTC_677 0929-0063 136 µM -0.600178159950147 0.296323267834578 no 2378 0.274193753644697 3492 1539583
SGTC_402 epigallocatechin gallate 10 µM -0.60044999675345 0.296233020031817 no 2379 0.274103188006943 3444 65064 An antioxidant.
SGTC_3311 9131146 2.8755 µM -0.602478214433843 0.295560065110209 no 2380 0.273427930223973 3476 4900406 YPR165W RHO1
SGTC_1603 st002045 67.8 µM -0.603409105301894 0.295251434573006 no 2381 0.273118283215732 3537 5887985
SGTC_2059 5238311 157 µM -0.60391941339972 0.295082308366612 no 2382 0.272948610590317 3475 703021
SGTC_2611 pyromycin 23.93 µM -0.605829281505078 0.294449736603132 no 2383 0.272314061694478 3482 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2966 9084041 48.03 µM -0.609110612978025 0.293364383438094 no 2384 0.271225561704791 3398 17741380
SGTC_1263 0774-1208 64.8 µM -0.609307843425978 0.293299205397316 no 2385 0.271160204586777 3595 906585
SGTC_1717 st033143 58.0435 µM -0.609884672161145 0.293108621396783 no 2386 0.27096910339984 3575 674616
SGTC_1066 ketoconazole 628 nM -0.6109535401146 0.292755619724282 no 2387 0.270615169180665 3567 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_228 caffeine 993.056 µM -0.612155107288846 0.292359029001227 no 2388 0.270217570146354 3538 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2289 7946404 165.07 µM -0.612488369206271 0.292249076438072 no 2389 0.270107345422277 3547 1246120 YPR165W RHO1
SGTC_2453 5731132 22.18 µM -0.613010964169439 0.292076696274578 no 2390 0.269934545034976 3576 1362040
SGTC_1393 3470-5649 58.2 µM -0.613442333050252 0.291934443086409 no 2391 0.269791951011402 3455 4108395
SGTC_2487 5918373 44.05 µM -0.61344764744482 0.291932690751443 no 2392 0.269790194511417 3589 2876279
SGTC_676 falcarinol 140 µM -0.615520411242536 0.291249604529489 no 2393 0.269105546942515 3606 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2882 9058044 58.44 µM -0.616468414498564 0.290937435749194 no 2394 0.2687927060214 3510 18076804
SGTC_2436 5633522 8.09 µM -0.619851852578775 0.289824577449089 no 2395 0.267677663463464 3574 5724242
SGTC_3262 9137218 49.47 µM -0.621707263051372 0.289215156975007 no 2396 0.267067187464816 3427 17650664
SGTC_898 1000-0849 28.3 µM -0.622012681365716 0.289114898305186 no 2397 0.266966764701154 3530 6751807
SGTC_709 3807-1509 243 µM -0.62362695171697 0.288585258739002 no 2398 0.26643630315092 3593 1886677 YPL242C IQG1
SGTC_196 k015-0023 18.111 µM -0.624141940525639 0.288416387945164 no 2399 0.26626718616012 3548 5211998
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.624433265135082 0.288320879865115 no 2400 0.266171542242783 3560 229346 A bile salt which induces apoptosis.
SGTC_2307 7538926 6.34 µM -0.624660361305192 0.288246438830558 no 2401 0.266096997040073 3528 96582
SGTC_330 1488-0319 80.1 µM -0.625054168714936 0.288117372145967 no 2402 0.265967753291655 3524 6846614
SGTC_2857 9024691 58.44 µM -0.625645421106402 0.287923645942496 no 2403 0.265773769761474 3548 16478292
SGTC_1339 1486-1321 22.7 µM -0.625839381949034 0.28786010729961 no 2404 0.265710148928073 3523 3469382
SGTC_2976 9009005 19.48 µM -0.625990207136186 0.287810703823281 no 2405 0.265660682299777 3589 2993148
SGTC_1756 st041558 35.5 µM -0.626070413785769 0.287784433401563 no 2406 0.265634378565528 3643 3955792
SGTC_1854 st056233 32.9 µM -0.626579035834294 0.28761786865326 no 2407 0.265467606945247 3525 5393174
SGTC_1084 voriconazole 435 nM -0.627115787309759 0.287442141446731 no 2408 0.265291669623275 3565 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2587 piperic acid 92.2 µM -0.627237889866074 0.287402173349358 no 2409 0.265251654903127 3487 5370536
SGTC_2601 securinine 100 µM -0.627928932196451 0.287176022501961 no 2410 0.265025248400602 3503 442872 A GABA receptor antagonist.
SGTC_1330 1469-0054 61.8 µM -0.628058073962461 0.287133768849217 no 2411 0.264982948518085 3566 7102664
SGTC_3146 9095609 49.47 µM -0.631491919080117 0.286011336608603 no 2412 0.2638594656587 3548 17173999
SGTC_2822 7994718 71.43 µM -0.63162028555673 0.285969417500647 no 2413 0.263817513949207 3534 1018011
SGTC_2534 helenine 20.12 µM -0.631635872627004 0.285964327616003 no 2414 0.263812420138614 3569 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3286 9117135 37.221 µM -0.632249246998886 0.285764067289665 no 2415 0.263612010948241 3490 3438150
SGTC_1640 st009078 66.4 µM -0.632860757321767 0.285564481981094 no 2416 0.263412288153606 3572 690618
SGTC_472 calcifediol 10 µM -0.632946233816868 0.285536589368997 no 2417 0.263384377192683 3548 5283731 A vitamin D metabolite.
SGTC_2735 sertaconazole 140 nM -0.633636569292263 0.28531136726943 no 2418 0.263159014712052 3611 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1028 k015-0029 4.8 µM -0.633837578709313 0.285245803814648 no 2419 0.263093412994076 3571 4588309
SGTC_2293 7624732 200 µM -0.635258256920538 0.284782624478407 no 2420 0.2626299968097 3553 894453
SGTC_2283 7944793 200 µM -0.636436663591211 0.284398704712925 no 2421 0.262245925221855 3545 2970533
SGTC_2626 ethyl orsellinate 100 µM -0.63681371422689 0.284275915501473 no 2422 0.262123095976923 3559 75653 A natural product.
SGTC_925 2064-1272 59.6 µM -0.637226731072744 0.284141442728726 no 2423 0.261988584105077 3514 6815817
SGTC_3321 9137793 26.8275 µM -0.637332744005142 0.284106931239743 no 2424 0.261954063381572 3574 4904192
SGTC_378 3970-0959 8.33 µM -0.637821814622386 0.283947744975314 no 2425 0.261794838753893 3575 6615653
SGTC_2855 9016525 58.44 µM -0.638024293079955 0.283881853308686 no 2426 0.261728933243667 3593 43811474
SGTC_3229 9132204 49.47 µM -0.639364764260403 0.283445814428924 no 2427 0.261292832826982 3570 17682924
SGTC_2475 5812728 15.03 µM -0.639467141680051 0.283412525506712 no 2428 0.261259541355147 3583 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1898 st060199 18.6 µM -0.640418166141568 0.283103381108587 no 2429 0.260950387851686 3589 688866
SGTC_1131 3454-3128 32.3 µM -0.641394387550591 0.282786214482534 no 2430 0.26063323925296 3565 710982
SGTC_149 3970-0822 46.1 µM -0.642388485151813 0.282463415538998 no 2431 0.260310487156037 3632 3114250 YBL034C STU1
SGTC_2013 4024628 200 µM -0.643224194618497 0.282192184857014 no 2432 0.260039318091915 3602 5230760
SGTC_1929 genistein trimethyl ether 50.5 µM -0.645314418711796 0.281514349097527 no 2433 0.259361725336703 3618 136420
SGTC_2982 9019404 25.97 µM -0.647290936052033 0.280874110524607 no 2434 0.258721833310848 3483 22333232
SGTC_135 0933-0004 26.348 µM -0.648067168256174 0.280622864039343 no 2435 0.258470753946322 3572 21230617 YGL099W LSG1
SGTC_561 1550-0330 72.9 µM -0.649128844510801 0.280279402789667 no 2436 0.258127549589242 3548 6812934
SGTC_2659 sanguinarine 24.21 µM -0.649254419266723 0.280238791763529 no 2437 0.258086971111348 3549 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2372 9071633 200 µM -0.649657130240908 0.280108573785313 no 2438 0.257956860599534 3622 21321366
SGTC_762 1165-0429 115 µM -0.651110560933155 0.279638846025364 no 2439 0.257487559822647 3596 5967793
SGTC_2541 muurolladie-3-one 83.07 µM -0.651362782582398 0.27955737058714 no 2440 0.257406164718518 3623 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_932 2857-0803 154 µM -0.653209378869413 0.278961213874421 no 2441 0.256810652326368 3668 674898
SGTC_1701 st028638 40.4 µM -0.654021834632659 0.27869911600717 no 2442 0.256548869242196 3587 3490878
SGTC_1851 st056236 18.9 µM -0.654903101508518 0.278414955324881 no 2443 0.256265071618623 3631 5393171
SGTC_1440 4100-1550 40 µM -0.65514539437189 0.278336853793766 no 2444 0.256187073847074 3614 742806
SGTC_1241 0364-0022 50.8 µM -0.656229251808533 0.277987610178647 no 2445 0.255838315187412 3589 4563895
SGTC_3356 9151811 4.48 µM -0.656645905555771 0.277853411751614 no 2446 0.255704312232693 3583 1859254 YPR165W RHO1
SGTC_1852 st056254 31.4 µM -0.657117051121529 0.277701700372772 no 2447 0.25555282794222 3564 442583
SGTC_1327 1436-0082 2.18 µM -0.657145411584953 0.277692569443828 no 2448 0.255543710887711 3583 15992205
SGTC_236 1509-0011 5.31 µM -0.657420218205706 0.27760410035649 no 2449 0.255455377445608 3687 3107280
SGTC_1565 sinapyl alcohol 95.1 µM -0.66034949086561 0.276661929954614 no 2450 0.254514788637311 3590 5280507 A phenol propionate derived from cinnamic acid.
SGTC_821 1114-0266 29.2 µM -0.66185263317866 0.276179068819749 no 2451 0.254032835358243 3607 3123235
SGTC_310 1273-0058 1.06 µM -0.662890171565187 0.275846017179817 no 2452 0.253700448424038 3636 2734232
SGTC_771 0250-0039 27.3 µM -0.663183670796212 0.275751839231857 no 2453 0.253606464146823 3598 3005115
SGTC_868 0527-0199 213 µM -0.663851042197584 0.275537752128167 no 2454 0.253392826673241 3563 2849450
SGTC_2911 7942208 15.64 µM -0.664017231909763 0.275484452588961 no 2455 0.253339641100141 3597 1243384
SGTC_1430 4049-0248 69.1 µM -0.664138152712624 0.275445674657312 no 2456 0.253300946591854 3657 22774488
SGTC_2445 5742597 35.57 µM -0.664574038894897 0.275305913187136 no 2457 0.253161489340723 3579 1774255
SGTC_2056 5235370 200 µM -0.667993220745808 0.274210807407932 no 2458 0.252068959943522 3607 5511916
SGTC_1406 3909-7906 11.9 µM -0.668123974356872 0.274168971997947 no 2459 0.252027229745406 3640 X1406
SGTC_2570 licareol 100 µM -0.67051509004879 0.273404476511969 no 2460 0.25126474510092 3581 443158
SGTC_654 1124-0271 80.9 µM -0.673263066980259 0.272527189700974 no 2461 0.25038997239677 3637 5403748
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.674490759476595 0.27213570321891 no 2462 0.249999679274407 3644 6708739 YPR165W RHO1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.676982592613452 0.271341968210059 no 2463 0.249208499500095 3606 756377
SGTC_1911 st060208 74.3 µM -0.678134876379055 0.270975316487765 no 2464 0.248843089630942 3647 688783
SGTC_279 1273-0055 2.93 µM -0.678937066551854 0.270720209055964 no 2465 0.248588869226955 3683 2847562
SGTC_1958 st076513 41.9 µM -0.680092818455177 0.270352875131334 no 2466 0.248222845716341 3614 732122 YGL099W LSG1
SGTC_1462 k081-0014 26.5 µM -0.680422289541989 0.270248204620604 no 2467 0.24811855577727 3447 3270634
SGTC_934 2950-0684 338 µM -0.681788760808997 0.269814303292522 no 2468 0.247686266047022 3650 1121253
SGTC_257 daunorubicin 18.5 µM -0.68480463622199 0.268857895915999 no 2469 0.246733604691055 3685 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1966 st070145 16.1 µM -0.686953011426297 0.268177633812854 no 2470 0.246056169695275 3610 3748532
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.687094178288744 0.268132965044537 no 2471 0.246011691309035 3694 1377
SGTC_2712 st079126 47.7 µM -0.688804420365429 0.267592098824626 no 2472 0.245473176773876 3644 3152970
SGTC_1750 st081859 2.357 µM -0.689781448892678 0.267283359359396 no 2473 0.245165818242294 3667 5291695
SGTC_2650 prasterone 100 µM -0.690334115761331 0.267108797133675 no 2474 0.244992049212723 3624 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_103 0844-0104 51.839 µM -0.691097775334634 0.266867686697446 no 2475 0.244752049122193 3701 5375804
SGTC_1855 st056195 39.6 µM -0.691999449816816 0.266583142412679 no 2476 0.244468837251346 3620 4028379
SGTC_712 r015-0009 80.6 µM -0.692954587805574 0.266281893900302 no 2477 0.244169025417574 3644 6813872 YLR060W FRS1
SGTC_2339 9000433 200 µM -0.693113803970274 0.26623169421641 no 2478 0.244119067746257 3650 2988954
SGTC_2760 etidronate 98.04 µM -0.694640579486875 0.265750556497975 no 2479 0.243640287401011 3664 3305 A chelator and antioxidant.
SGTC_3034 9090421 49.47 µM -0.69490121934385 0.265668464284551 no 2480 0.243558604249225 3604 17173761
SGTC_2386 9075165 157.42 µM -0.696038077661697 0.265310545087598 no 2481 0.243202491889426 3645 16452277
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.696210237737223 0.265256364962192 no 2482 0.243148588586201 3807 16725076
SGTC_1290 0986-0249 10.2 µM -0.696829037910667 0.265061670088792 no 2483 0.242954895659178 3623 53329
SGTC_1562 morin hydrate 59.1 µM -0.697369819959986 0.264891581743998 no 2484 0.242785691845739 3702 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_716 1683-5115 658 µM -0.698532281200582 0.264526148931764 no 2485 0.242422188537175 3694 723597
SGTC_2665 lovastatin 100 µM -0.69908618191329 0.264352114266604 no 2486 0.242249086757912 3677 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3085 9117376 49.47 µM -0.699498825980395 0.264222500097796 no 2487 0.24212017322933 3732 16480349
SGTC_1011 4112-3381 17.4 µM -0.699562004181093 0.26420265827393 no 2488 0.242100439104109 3719 2877139
SGTC_400 oxethazaine 37.5 µM -0.701736102413751 0.263520320997028 no 2489 0.241421876956641 3670 4621 A local anesthetic.
SGTC_1282 0886-0010 32.4 µM -0.702146035113154 0.263391765117838 no 2490 0.241294047905969 3733 2836211 YNL267W PIK1
SGTC_2961 9083290 32.55 µM -0.702612779886579 0.263245431827824 no 2491 0.241148547972303 3649 17741490
SGTC_352 k048-0007 5.11 µM -0.703031176117429 0.263114292022118 no 2492 0.241018160444276 3676 6811911
SGTC_2198 6589944 200 µM -0.703371302178747 0.26300770938989 no 2493 0.240912193013458 3651 5290268
SGTC_1296 1068-0102 11.9 µM -0.705195728199658 0.262436380233495 no 2494 0.240344219680005 3677 767053
SGTC_2683 piperine 63.03 µM -0.706789315589585 0.261937859913587 no 2495 0.23984870763261 3660 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2154 5570129 200 µM -0.708136107238522 0.261516923367184 no 2496 0.239430369442932 3702 673366
SGTC_1347 1493-0251 600 nM -0.70947569981073 0.261098581645577 no 2497 0.239014663009918 3724 3986378
SGTC_3023 9089636 49.47 µM -0.709654295676215 0.261042833894012 no 2498 0.238959270424825 3758 17249241
SGTC_1945 st075991 56.6 µM -0.709943528171598 0.260952564487051 no 2499 0.238869578112207 3617 1084980
SGTC_2827 7993847 71.43 µM -0.710664528156579 0.260727610431905 no 2500 0.238646072915268 3683 2985692
SGTC_2786 7743617 45.45 µM -0.71076179774053 0.260697269684942 no 2501 0.238615928755269 3638 583674
SGTC_861 0443-0273 110 µM -0.711194019750568 0.260562471115744 no 2502 0.23848200695655 3714 6149169
SGTC_2320 7373003 200 µM -0.711604812495639 0.260434389032909 no 2503 0.238354763056683 3714 5415828
SGTC_2499 avocadenofuran 51.48 µM -0.712096977185744 0.260280978498881 no 2504 0.238202363000785 3686 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1919 st067113 52.3 µM -0.712237949531174 0.260237045196969 no 2505 0.238158720391168 3710 1268243
SGTC_1191 1487-1166 10.6 µM -0.713096545595175 0.25996955071549 no 2506 0.237893008469576 3763 3955771
SGTC_2725 haloperidol 53.21 µM -0.713839794418341 0.259738107075626 no 2507 0.237663124679844 3661 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2878 9043973 25.97 µM -0.713928112307159 0.259710612435815 no 2508 0.237635816425984 3752 6465167
SGTC_1369 1866-0067 208 µM -0.717375512677424 0.258638561590958 no 2509 0.236571212427079 3704 3531355
SGTC_1924 st058459 75.1 µM -0.71790786580456 0.258473218223746 no 2510 0.236407048791884 3661 688683
SGTC_457 grayanotoxin iii 135 µM -0.719682879266314 0.257922313318706 no 2511 0.235860134941374 3657 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_302 1094-0063 18.9 µM -0.72011206101548 0.257789201149595 no 2512 0.235728001046143 3669 5440289
SGTC_2112 5488546 200 µM -0.720273301592355 0.257739201055724 no 2513 0.235678369818105 3697 600757
SGTC_3109 9122853 49.47 µM -0.720313351436863 0.257726782530746 no 2514 0.235666043027155 3759 1234709
SGTC_2561 acetosyringone 100 µM -0.721976349446628 0.25721139989582 no 2515 0.235154509184757 3722 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_666 0272-0154 136 µM -0.722180839840303 0.257148062932296 no 2516 0.235091650838843 3746 6870312
SGTC_1540 guanosine 70.6 µM -0.7226344783858 0.25700758608009 no 2517 0.234952239926595 3650 6802 Guanosine is a purine nucleoside
SGTC_1817 st052116 64.4 µM -0.723089675372603 0.256866666766405 no 2518 0.23481239600781 3708 4361398
SGTC_2739 tacrine 100.86 µM -0.724405085513826 0.256459669843953 no 2519 0.234408539317706 3711 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2746 daunorubicin 9.88 µM -0.726182536224579 0.255910248610879 no 2520 0.233863438218756 3601 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1193 1488-0126 41.5 µM -0.728254086831744 0.255270695176237 no 2521 0.233229031134155 3736 1384710
SGTC_2806 7952793 58.44 µM -0.729021345347784 0.255034030348905 no 2522 0.232994302807759 3741 2972490
SGTC_25 0118-0223 35.662 µM -0.729972864054787 0.254740689044222 no 2523 0.232703385871695 3740 5333628
SGTC_250 brefeldin a 552.239 µM -0.730170921214793 0.254679652721539 no 2524 0.232642857351765 3614 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3354 9151612 71.43 µM -0.7334364341202 0.253674407478189 no 2525 0.231646142153459 3741 27261949
SGTC_2231 micatex 6.853 µM -0.734336266914948 0.253397772441621 no 2526 0.231371909779821 3759 20737 An antifungal of unknown mechanism.
SGTC_1692 fluoroquinolonic acid 71 µM -0.734904187555858 0.253223258602078 no 2527 0.231198923944614 3747 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1884 5633444 25 µM -0.73558452232017 0.25301428475271 no 2528 0.230991792351939 3761 5724239
SGTC_1629 st005085 44.9 µM -0.737377881998721 0.252463865679321 no 2529 0.230446291056563 3740 24207091
SGTC_2670 beta-carotene 100 µM -0.737821908086022 0.252327682438688 no 2530 0.230311339216252 3660 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2341 7987486 176.74 µM -0.738195994034581 0.252212979971882 no 2531 0.230197678431729 3729 1258686
SGTC_2526 patulin 37.61 µM -0.738714737667122 0.252053967989152 no 2532 0.230040117367129 3788 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_790 1575-0012 79.1 µM -0.739888890668218 0.251694246919995 no 2533 0.229683707931155 3820 378741 YLR208W SEC13
SGTC_3050 9093513 49.47 µM -0.74004300922888 0.251647050303687 no 2534 0.229636948833295 3747 25236664
SGTC_1049 3226-0134 66 µM -0.740231488623064 0.251589337525657 no 2535 0.22957977201288 3778 5702385
SGTC_2618 avocadyne 43.43 µM -0.740586958212279 0.251480511038488 no 2536 0.229471959011549 3676 3015189
SGTC_208 k072-0098 12.366 µM -0.740862108841856 0.251396291164219 no 2537 0.229388526026137 3740 5948901
SGTC_2076 5212012 200 µM -0.74212112570235 0.251011113441502 no 2538 0.229006975625505 3650 604802
SGTC_2048 5246248 200 µM -0.743230592020282 0.250671947522034 no 2539 0.228671042498911 3719 677046
SGTC_2918 7977171 22.06 µM -0.743776130447177 0.250505264470237 no 2540 0.228505961528484 3687 2236483
SGTC_1042 0350-0096 82 µM -0.745432042611168 0.249999679274407 no 2541 0.228005289583829 3749 3122515
SGTC_3221 9128209 49.47 µM -0.748825543352919 0.248965265504189 no 2542 0.226981180965172 3791 16460723
SGTC_1953 st076800 12.1 µM -0.749913450680156 0.248634130180052 no 2543 0.226653416462695 3784 297591
SGTC_1354 1498-1681 81 µM -0.749937958775729 0.248626673151805 no 2544 0.226646035746495 3812 5754243
SGTC_2437 5741531 144.16 µM -0.749955459664214 0.248621348265074 no 2545 0.226640765363241 3781 2262990
SGTC_8 0354-0001 70 µM -0.750295014688448 0.248518045989563 no 2546 0.226538522240115 3782 4993152
SGTC_870 0573-2213 57.6 µM -0.750753118039028 0.248378714197103 no 2547 0.226400624404297 3754 3916321
SGTC_298 1391-0729 10 µM -0.75130643841489 0.248210477752638 no 2548 0.22623412765714 3716 3237558
SGTC_2273 7815444 169.05 µM -0.751432860463294 0.248172047799562 no 2549 0.226196096369058 3701 2824616
SGTC_1590 st077108 57.8 µM -0.751477429530161 0.248158500388189 no 2550 0.22618268960849 3708 5489485
SGTC_3296 9122258 64.045 µM -0.754513311614788 0.247236629405708 no 2551 0.225270527627383 3783 4730474
SGTC_1419 3993-2473 62.6 µM -0.754545890586468 0.247226746469112 no 2552 0.225260750252344 3820 704026
SGTC_838 0109-0203 71.4 µM -0.757402157063587 0.246361110493863 no 2553 0.224404482105962 3774 759422
SGTC_1466 k213-0079 57.5 µM -0.758091266711852 0.24615250861771 no 2554 0.224198173771661 3723 3657981
SGTC_1881 5652484 16 µM -0.758323111454249 0.246082347695101 no 2555 0.224128787410101 3723 2255129
SGTC_3035 9091303 49.47 µM -0.759280279400474 0.245792802852291 no 2556 0.223842455886604 3803 25237002
SGTC_1439 4092-1168 46 µM -0.759458352302232 0.245738955697829 no 2557 0.223789209304633 3761 2886240
SGTC_1704 st028805 70.8 µM -0.760706705440246 0.24536164626771 no 2558 0.223416134411233 3791 2876101
SGTC_2525 harmine 47.85 µM -0.761330499929687 0.245173223766154 no 2559 0.223229843819923 3772 5280953 A monoamine oxidase inhibitor
SGTC_1712 st032288 53.4 µM -0.762583565184574 0.244794959863836 no 2560 0.222855894525399 3739 2883011
SGTC_2005 4024620 188 µM -0.762597406347439 0.244790783374826 no 2561 0.222851765933885 3760 236743
SGTC_2404 5161160 200 µM -0.762859741101258 0.244711632668191 no 2562 0.222773524026697 3735 2831543
SGTC_418 lividomycin a 100 µM -0.763646687923268 0.244474280567515 no 2563 0.22253890937296 3770 72394 An antibiotic.
SGTC_2409 alverine citrate 63.97 µM -0.764548711696702 0.244202372585996 no 2564 0.222270159883076 3956 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2343 7990716 14.84 µM -0.765673358021384 0.243863585295822 no 2565 0.221935341620695 3766 6456862
SGTC_331 k048-0133 24.5 µM -0.766431678829318 0.243635292773239 no 2566 0.221709744726655 3759 6813582
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.766884513055668 0.243499022056264 no 2567 0.221575091166699 3807 368090
SGTC_1610 st001799 48.1 µM -0.766891319347872 0.243496974163193 no 2568 0.221573067622684 3712 621897
SGTC_3243 9134147 49.47 µM -0.767109030256812 0.243431473705891 no 2569 0.221508346675428 3823 24282180
SGTC_533 1222-0222 6.71 µM -0.772959900989546 0.241674752816029 no 2570 0.219773056165183 3880 3982874
SGTC_2907 7721985 69.9 µM -0.773793300701333 0.241425086127705 no 2571 0.219526517424301 3796 3267881
SGTC_2799 7812892 81.82 µM -0.776365883643176 0.240655286128061 no 2572 0.218766491245473 3794 20205235
SGTC_1459 k035-0031 35.7 µM -0.776438047845236 0.240633711547494 no 2573 0.218745193407433 3658 3877128 YMR208W ERG12
SGTC_294 k038-0071 157 µM -0.777665343234765 0.240266954280136 no 2574 0.218383164186217 3814 24152826
SGTC_373 0844-0104 25.9 µM -0.779656495555317 0.239672579292982 no 2575 0.217796546214157 3856 5375804
SGTC_1558 st069300 45.6 µM -0.77982660313956 0.239621838043253 no 2576 0.217746472604808 3733 24208000
SGTC_597 k018-0003 82.8 µM -0.781894984494343 0.239005331638446 no 2577 0.217138146415467 3888 6786234
SGTC_1139 k015-0024 46.9 µM -0.781931340571916 0.238994503024891 no 2578 0.21712746261354 3781 2766652
SGTC_1373 2887-0003 58.5 µM -0.782585190572475 0.238799800395404 no 2579 0.216935370420078 3809 776948
SGTC_3184 9108758 49.47 µM -0.783428909212181 0.238548687194317 no 2580 0.216687642633398 3808 902885
SGTC_2353 9059630 146.67 µM -0.785459691078829 0.237944865357266 no 2581 0.216092047503158 3851 4779114
SGTC_466 geldanamycin 89.2 µM -0.785555949054918 0.237916265340236 no 2582 0.216063840168535 3684 5288382 HSP90 inhibitor.
SGTC_1481 3346-2004 36 µM -0.78793135382414 0.237211086343003 no 2583 0.215368430083638 3829 2770522
SGTC_1352 1496-0991 99 µM -0.788644221265743 0.236999683811764 no 2584 0.215159988645925 3807 3000039
SGTC_1780 st038448 24.544 µM -0.789275645125511 0.23681252008059 no 2585 0.214975459036275 3884 728868 YDL195W SEC31
SGTC_1843 st055809 45.5 µM -0.789830163937263 0.236648219240952 no 2586 0.21481348026271 3857 16413835
SGTC_1722 st034304 3.6505 µM -0.791955992027468 0.236018929602493 no 2587 0.214193168521028 3840 4036148 YLR033W RSC58
SGTC_3092 9117248 49.47 µM -0.792028510173526 0.235997478988787 no 2588 0.214172026291817 3877 17141857
SGTC_1909 st060837 51.5 µM -0.792225449913637 0.235939230323971 no 2589 0.214114615822205 3839 678937
SGTC_2133 5320837 200 µM -0.792776755637491 0.235776213341361 no 2590 0.213953950738778 3811 2841355
SGTC_1709 st033179 39.1045 µM -0.793791790781843 0.235476237531967 no 2591 0.213658326259542 3792 573381
SGTC_3307 9126885 69.2785 µM -0.794027952339344 0.235406474343577 no 2592 0.213589579392834 3809 24824909
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.794893048646155 0.235151018448953 no 2593 0.213337859092959 3870 5282309
SGTC_2556 citropten 84.59 µM -0.796150920229872 0.234779852513571 no 2594 0.212972160242752 3863 2775 A potential DNA crosslinker.
SGTC_491 tetrandrine 80.3 µM -0.796591191986306 0.234650016065857 no 2595 0.212844247261488 3813 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1277 0873-0036 22 µM -0.79771656403635 0.234318323591767 no 2596 0.212517494675723 3885 5965735
SGTC_789 1309-1135 70.6 µM -0.798732172089374 0.234019205898517 no 2597 0.212222863842625 3821 3092424
SGTC_1061 3448-9325 110 µM -0.799446264043633 0.233809017666343 no 2598 0.212015846739959 3745 723482
SGTC_284 0988-0104 32.6 µM -0.79950000621775 0.23379320324813 no 2599 0.212000271524808 3833 4666532
SGTC_1294 1000-1494 117 µM -0.802059118056035 0.233040833900622 no 2600 0.211259380940835 3823 712797 YDL207W GLE1
SGTC_1450 4112-4260 37.6 µM -0.80208153226851 0.2330342501506 no 2601 0.211252898492252 3798 1633175
SGTC_1775 st081588 35.1725 µM -0.804274402548337 0.232390635669269 no 2602 0.210619258747646 3860 1426443 YGL099W LSG1
SGTC_3026 9090633 49.47 µM -0.804470679773501 0.23233307592287 no 2603 0.210562597985375 3851 25236842
SGTC_2593 nobiletin 86.24 µM -0.804516957829628 0.232319505696561 no 2604 0.210549239868395 3856 72344 An anti-infammatory.
SGTC_111 0083-0039 52.457 µM -0.806211337015654 0.23182296252957 no 2605 0.210060501451986 3733 759313
SGTC_2781 5567276 71.43 µM -0.808655481535717 0.231107740864159 no 2606 0.209356671011129 3897 2853274
SGTC_3098 9119039 49.47 µM -0.808722215007512 0.231088230161673 no 2607 0.209337473525894 3837 17161528
SGTC_307 1501-1223 22.3 µM -0.809727043718287 0.230794561995509 no 2608 0.209048535688105 3850 2830329
SGTC_1468 k284-1086 134 µM -0.811941489920496 0.230148111141 no 2609 0.208412602872244 3853 15996457
SGTC_2006 4011487 200 µM -0.812380390069169 0.230020105869662 no 2610 0.208286697488365 3902 45595294
SGTC_397 arbidol 50 µM -0.812591502476798 0.229958549109109 no 2611 0.208226152573206 3908 131410 A RNA synthesis inhibitor.
SGTC_230 MPP+ 141.667 µM -0.81337474644267 0.229730249169459 no 2612 0.208001616830756 3847 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1651 st011928 86.1 µM -0.815147089311477 0.229214115573757 no 2613 0.207494060040568 3863 720198
SGTC_2929 9013348 24.6 µM -0.815472104096009 0.229119536858498 no 2614 0.207401063037437 3885 2995952
SGTC_640 3381-0960 37.1 µM -0.816638714669416 0.228780235643101 no 2615 0.20706746189002 3892 1745025
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.817072824408149 0.228654049652539 no 2616 0.206943406005409 3798 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_100 0086-0128 49.5915 µM -0.817178804384604 0.228623249580593 no 2617 0.206913126704423 3912 93297
SGTC_3132 9126706 49.47 µM -0.819387456540105 0.227981898022911 no 2618 0.20628269458828 3920 850858
SGTC_1116 jasmonic acid 1.58368 µM -0.822052098339596 0.227209484351894 no 2619 0.205523623212618 3915 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1980 st071811 45.7 µM -0.823130460674376 0.226897313540145 no 2620 0.205216904200908 3986 4974850
SGTC_2414 st077232 92.9 µM -0.823692050515316 0.226734836984548 no 2621 0.205057278743846 3842 729801
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.82559423198965 0.226184994763764 no 2622 0.204517154111117 3894 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_203 k066-0004 30.888 µM -0.826186502597919 0.226013947699149 no 2623 0.204349151814146 3923 6795412
SGTC_306 1672-3436 11.6 µM -0.827141197443567 0.225738386924185 no 2624 0.204078518004722 3886 6797378
SGTC_2584 androsterone 48.74 µM -0.827226677163423 0.225713723541354 no 2625 0.204054296908775 3867 2754130 A steroid.
SGTC_2895 9054447 58.44 µM -0.830743386205388 0.224700373138132 no 2626 0.203059305488532 3904 2697450
SGTC_3304 9125678 46.087 µM -0.830845384850426 0.224671020473379 no 2627 0.20303049004894 3832 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_113 0099-0221 2.5 µM -0.831290853433576 0.224542851224852 no 2628 0.202904670204357 3843 89219
SGTC_2850 9015429 58.44 µM -0.833148523823539 0.224008813789663 no 2629 0.202380484970958 3944 6457570
SGTC_2756 carbadox 75.1 µM -0.83349068309971 0.223910529633995 no 2630 0.202284025104232 3892 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3072 9116419 49.47 µM -0.833609566879564 0.223876386386281 no 2631 0.202250516409909 3901 17170162
SGTC_1372 2752-0194 270 µM -0.833677160642735 0.22385697487583 no 2632 0.202231465848798 3838 823334
SGTC_452 diindolylmethane 8 µM -0.83591199924927 0.223215714999213 no 2633 0.201602205738592 3894 3071 Inhibits expression of several cancer promoting factors.
SGTC_1230 0170-0365 3.77 µM -0.836265086587988 0.223114496603347 no 2634 0.2015028948832 3960 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2610 ononetin 44.17 µM -0.836337081344202 0.223093861309419 no 2635 0.201482648928591 3888 259632
SGTC_1561 5-methoxyflavone 52.9 µM -0.83867547900288 0.222424215806751 no 2636 0.200825721057867 3818 94525
SGTC_3135 9127742 49.47 µM -0.839299820896701 0.222245617501095 no 2637 0.200650541858095 3972 3643468
SGTC_693 4161-2696 114 µM -0.839420224025227 0.222211184577034 no 2638 0.200616769442591 3920 805759
SGTC_2317 5986382 200 µM -0.839946527371824 0.222060707924844 no 2639 0.200469184317475 3912 877883
SGTC_1788 fluconazole 20 µM -0.840580544209033 0.221879511920573 no 2640 0.200291480970799 3935 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1199 1638-0010 4.46 µM -0.850452055766007 0.21906924076017 no 2641 0.197536902596402 3882 3111136
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.850824726196763 0.218963549571799 no 2642 0.197433362070104 3944 279621
SGTC_2274 7947094 46.08 µM -0.852175768414137 0.218580633269857 no 2643 0.197058271807698 3863 2971028
SGTC_2279 7948423 32.93 µM -0.852720799770975 0.21842626810373 no 2644 0.196907076753424 3831 1247112
SGTC_1628 st004252 77.7 µM -0.85334448855842 0.218249702436341 no 2645 0.196734147837013 3936 692968
SGTC_729 4092-0585 94.1 µM -0.856735361386682 0.217291189876672 no 2646 0.195795577931186 3925 2169061
SGTC_1753 st043925 64 µM -0.857447669410867 0.217090148147956 no 2647 0.19559876199372 3969 670181
SGTC_1281 0884-0031 11.8 µM -0.857706202753012 0.217017206321211 no 2648 0.195527357055179 3920 1548255
SGTC_317 4495-0002 170 µM -0.858891573937158 0.216682950622194 no 2649 0.195200169293581 3951 15991618
SGTC_80 0159-0065 512.242 µM -0.860859907190487 0.216128570394264 no 2650 0.194657602782247 3811 1548079
SGTC_2261 9010538 184.68 µM -0.86166241958952 0.215902779055502 no 2651 0.194436655668299 3917 6457250
SGTC_1203 3992-3522 103 µM -0.864648213520453 0.215063910521745 no 2652 0.193615950620013 4036 5322312
SGTC_1857 st056007 79.3 µM -0.865371846519284 0.214860888740354 no 2653 0.193417364146229 3920 619834
SGTC_2731 amoxapine 43.43 µM -0.866019020184128 0.214679412660506 no 2654 0.193239865701858 4002 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1177 0983-0204 23.6 µM -0.866206911925652 0.214626742013656 no 2655 0.193188351806428 3969 766818
SGTC_3196 9111891 49.47 µM -0.867297620097275 0.214321138243648 no 2656 0.192889480169839 3920 18891510
SGTC_2309 7664088 163.95 µM -0.867398442297959 0.214292901818208 no 2657 0.192861867527065 3936 704922
SGTC_3186 9110464 49.47 µM -0.86749877088511 0.214264805783132 no 2658 0.192834392469514 3941 17018021
SGTC_1380 2291-0730 164 µM -0.868254948354474 0.214053114663376 no 2659 0.192627389645521 3971 2999191
SGTC_1808 st050063 61.5 µM -0.870065286292075 0.213546807222215 no 2660 0.1921323634946 3889 4011993
SGTC_766 1391-0721 126 µM -0.870798068472884 0.213342064459798 no 2661 0.191932210048003 3988 1020919 YIL115C NUP159
SGTC_3097 9117246 49.47 µM -0.871252075292114 0.213215270273486 no 2662 0.191808265862786 3934 16423892
SGTC_2718 lomofungin 53.02 µM -0.872555817696743 0.21285140788774 no 2663 0.19145261576207 3892 5351222 A RNA synthesis inhibitor.
SGTC_715 0868-0130 184 µM -0.872989004793378 0.212730589660829 no 2664 0.191334535408811 3960 2876258
SGTC_1205 4161-2785 76 µM -0.87346560409593 0.212597709804892 no 2665 0.191204673115965 4032 3498106
SGTC_1111 tnp00062 510.699 nM -0.874974801522547 0.212177252911378 no 2666 0.190793808299829 4003 676306
SGTC_1030 k029-0042 36.7 µM -0.876996417497419 0.211614800491694 no 2667 0.190244291969855 3924 6080581
SGTC_368 fentichlor 4.58 µM -0.877189622166664 0.211561092969747 no 2668 0.19019182596291 3993 7329 A pesticide.
SGTC_996 3970-0799 1.8 µM -0.87751193832367 0.211471512474117 no 2669 0.190104318665584 3973 6615648 YGL040C HEM2
SGTC_926 2268-1401 59.4 µM -0.878274879865647 0.211259558639379 no 2670 0.189897282300473 3913 2931578
SGTC_880 0833-0487 87.2 µM -0.87827678031694 0.211259030827849 no 2671 0.189896766755826 3929 76075
SGTC_396 dithiazanine 1.25 µM -0.879017370736937 0.211053405784224 no 2672 0.189695928707643 3937 10578 An antihelmenthic.
SGTC_2193 5925765 200 µM -0.88121817611664 0.210443044562232 no 2673 0.189099871631515 3934 877370
SGTC_134 0269-0018 6.916 µM -0.884047861753954 0.209659797093242 no 2674 0.18833518832304 3908 4378915
SGTC_176 1486-1328 72.834 µM -0.885139305828213 0.209358147780018 no 2675 0.188040751196249 4024 22310231
SGTC_1113 artemisinin 1.17947 µM -0.885593515895467 0.20923269016392 no 2676 0.187918303445019 3979 2240 An anti-malaria and mitochondrial poison.
SGTC_1410 3909-8106 77.9 µM -0.886010215530554 0.209117632258891 no 2677 0.187806011216635 3983 1039210
SGTC_2572 astragaloside iv 100 µM -0.886246885250447 0.209052300288278 no 2678 0.187742251910968 4029 45006101 An anti-inflammatory agent.
SGTC_3200 9114385 49.47 µM -0.88659370217628 0.208956584226105 no 2679 0.187648842878621 4010 17018030 YLR208W SEC13
SGTC_2764 methyldopa 94.69 µM -0.888408139596479 0.208456248760444 no 2680 0.187160624290174 3940 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3330 9141424 71.43 µM -0.888594117209179 0.208405004937909 no 2681 0.1871106269082 4034 27261020
SGTC_1229 0139-0193 12.2 µM -0.888731573553907 0.208367135323828 no 2682 0.187073679074638 4014 3090752
SGTC_446 go6976 132 µM -0.888979241511353 0.208298912343041 no 2683 0.18700711809821 3965 3501 A protein kinase C inhibitor.
SGTC_2732 terfenadine 20 µM -0.889744959820048 0.20808806981714 no 2684 0.18680142333303 3955 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_743 1275-0778 158 µM -0.890908443606392 0.207767942758678 no 2685 0.186489145062007 3952 2849257 YMR203W TOM40
SGTC_593 1203-0218 61.7 µM -0.891571454859827 0.207585648538376 no 2686 0.186311337988992 4005 3666956
SGTC_1796 st049173 110.4 µM -0.894971654365147 0.206652253699852 no 2687 0.185401120362206 3889 94134
SGTC_1684 st024538 14.6195 µM -0.895105913005131 0.206615449199218 no 2688 0.185365236691278 3948 6732859
SGTC_2380 9035439 200 µM -0.896201477445522 0.206315265768629 no 2689 0.185072583381271 4075 6462575
SGTC_720 r052-1644 49.9 µM -0.896483727944198 0.20623797134105 no 2690 0.184997233571139 3989 1422863 YOR257W CDC31
SGTC_212 3807-4682 38.772 µM -0.897381701662963 0.205992175031052 no 2691 0.184757636626497 4036 3125501 YBL034C STU1
SGTC_2702 st077768 96.8 µM -0.897754110355444 0.205890289092949 no 2692 0.184658327320798 3956 6484119
SGTC_170 4197-0004 226 µM -0.898334088280952 0.205731674590968 no 2693 0.184503732149017 4012 218692
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.898866500330843 0.205586132438784 no 2694 0.184361886719602 3862 17037758
SGTC_608 k048-0125 159 µM -0.8993755612917 0.205447030804877 no 2695 0.184226325963274 4012 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2428 5615643 7.78 µM -0.900898642265529 0.205031180659728 no 2696 0.18382110659673 4014 2253075
SGTC_1567 st069303 68.4 µM -0.901087596147787 0.204979625074792 no 2697 0.18377087369916 4047 5581319
SGTC_1799 st045822 46.1415 µM -0.901304915585573 0.204920339550245 no 2698 0.18371311046678 3915 3674992
SGTC_2997 9067075 71.4286 µM -0.902001524414967 0.204730370882811 no 2699 0.183528028973688 3992 27209819
SGTC_3057 9095946 49.47 µM -0.902718681347226 0.204534908120006 no 2700 0.18333760952278 3994 24540043
SGTC_3345 9148410 3.559 µM -0.903246591969045 0.204391095858664 no 2701 0.183197517482647 3939 4903596
SGTC_792 4534-1957 155 µM -0.903432547450976 0.204340452610658 no 2702 0.183148186241351 3920 1717904
SGTC_1412 3909-8563 178 µM -0.90428121524199 0.204109420686066 no 2703 0.182923152434044 4047 23767530
SGTC_1256 0570-0116 285 µM -0.904698607227629 0.203995851615402 no 2704 0.182812539584851 3988 410638
SGTC_604 1000-0114 314 µM -0.905535244628225 0.203768322571505 no 2705 0.182590948460788 3973 1572745
SGTC_297 0986-0032 24 µM -0.906558258937068 0.203490312787792 no 2706 0.18232022175298 3936 2847425
SGTC_1115 galangin 695.678 nM -0.908938987023508 0.202844213350747 no 2707 0.181691166382299 4011 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_489 paxilline 115 µM -0.910348363523494 0.202462304579053 no 2708 0.181319410156857 3967 105008 A toxic potassium channel blocker.
SGTC_1583 clindamycin 39.6 µM -0.910354821815154 0.202460555519965 no 2709 0.181317707727457 3956 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_326 k292-0812 17.5 µM -0.911426483449801 0.202170449188459 no 2710 0.181035352423608 3959 3579357
SGTC_3334 9142812 21.919 µM -0.91218201623163 0.201966070718882 no 2711 0.180836454620727 4012 45283678
SGTC_2373 9071805 200 µM -0.913350678128838 0.201650180785057 no 2712 0.180529068416647 3941 10149009
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.913803293508636 0.201527918156321 no 2713 0.180410107771604 3985 4620898
SGTC_3242 9133940 49.47 µM -0.914003366018868 0.201473887773144 no 2714 0.180357538504655 4005 17248444
SGTC_1219 1469-0211 33.1 µM -0.914223449980974 0.20141446324455 no 2715 0.180299722309779 3999 6822282
SGTC_1442 4112-3290 3 µM -0.914646721171878 0.201300205980452 no 2716 0.180188561399964 3955 704353
SGTC_1751 st044839 27.194 µM -0.915680830778489 0.201021223279567 no 2717 0.17991716102117 3952 5291326
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.917025499371801 0.200658804864366 no 2718 0.179564639118415 3995 688751
SGTC_1498 4478-3555 97.6 µM -0.917746946438857 0.200464520455217 no 2719 0.179375681691974 3924 3437919
SGTC_1409 3909-8004 61.9 µM -0.91794544368256 0.200411085327113 no 2720 0.179323714330267 3996 2119279
SGTC_1694 st024011 44.9 µM -0.918237672896289 0.200332433280186 no 2721 0.179247224799068 4014 2787533
SGTC_749 1000-0129 128 µM -0.918435604724913 0.200279171443534 no 2722 0.179195428792813 4058 708470
SGTC_2371 9071574 200 µM -0.918852176687796 0.200167103135851 no 2723 0.179086448464318 3999 45596039
SGTC_206 4546-0025 72.014 µM -0.920168802278175 0.19981314571228 no 2724 0.178742277316264 4046 6620745 YIL048W NEO1
SGTC_1976 st070609 63.5 µM -0.920790033161982 0.199646266790732 no 2725 0.17858002979284 3887 682556
SGTC_29 0299-0004 12.984 µM -0.921513732440284 0.199451967958492 no 2726 0.178391137492619 3889 16871 A napthoquinone isolated from Swertia calycina.
SGTC_847 0342-0274 5.54 µM -0.924673664132364 0.198604923767752 no 2727 0.177567841236183 4010 18097
SGTC_1641 st009299 47.1 µM -0.927256652417083 0.197914147930902 no 2728 0.176896647416304 3913 4046054
SGTC_3194 9111903 49.47 µM -0.928312373873653 0.197632231691004 no 2729 0.176622778641883 4042 17087251
SGTC_1570 verbenone 133 µM -0.929290435979017 0.197371270057925 no 2730 0.176369295173643 4035 29025 A natural terpanoid with antifungal properties.
SGTC_2382 9035899 200 µM -0.929700267109695 0.197261982954731 no 2731 0.176263148074483 3993 6462679
SGTC_3003 9075612 71.4286 µM -0.929837680587912 0.197225347958622 no 2732 0.176227566755088 4029 6501993
SGTC_1252 0493-0875 34.8 µM -0.93076839480605 0.196977324106911 no 2733 0.17598669085611 3997 3960963
SGTC_985 1493-0307 8.71 µM -0.931434252003281 0.196799997291978 no 2734 0.17581448994963 4023 3278274
SGTC_759 3486-0358 89.3 µM -0.931966678952091 0.196658274341264 no 2735 0.175676872973712 3982 875103
SGTC_3217 9129673 49.47 µM -0.933521078362473 0.196244873641453 no 2736 0.175275496268485 4042 17248312
SGTC_2800 7887935 81.82 µM -0.934386883749992 0.196014836793031 no 2737 0.175052180538193 4042 2961002
SGTC_71 0417-1750 47.813 µM -0.935068044683437 0.195833973363174 no 2738 0.174876616766968 4028 6811472
SGTC_1690 st023502 41.2 µM -0.936205000037085 0.195532312032814 no 2739 0.174583824656888 4021 24207482
SGTC_2075 5212009 200 µM -0.936461220960773 0.19546436950166 no 2740 0.174517884891806 3918 780898
SGTC_1033 k072-0102 21.3 µM -0.939190407826117 0.194741556576365 no 2741 0.173816496496432 4006 5965931
SGTC_656 4090-1979 187 µM -0.939626159661791 0.194626300370275 no 2742 0.173704676500284 4092 22330961
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.940870532675269 0.194297392727693 no 2743 0.173385605049455 3997 6312947
SGTC_2357 9067248 200 µM -0.942077870321432 0.19397859783724 no 2744 0.173076386735275 4024 9150235
SGTC_761 k216-0224 480 µM -0.94227819636286 0.193925733026599 no 2745 0.173025114058711 4028 1340404
SGTC_1436 4092-1007 8.32 µM -0.942437582041695 0.193883678398428 no 2746 0.172984326822719 3999 2881121
SGTC_3138 9097216 49.47 µM -0.943244397713535 0.193670881750462 no 2747 0.172777954458931 3992 25237486
SGTC_2772 vinpocetine 57.06 µM -0.94459112498927 0.193316001479979 no 2748 0.172433829867405 4039 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1214 0358-0031 63.7 µM -0.945372582099571 0.193110259358222 no 2749 0.172234347394091 4170 4301366
SGTC_392 N-ethylmaleimide 8.33 µM -0.94884388202708 0.192197951998425 no 2750 0.171350009842774 3970 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_919 tnp00227 403.569 nM -0.949176150958571 0.192110765440953 no 2751 0.171265514523783 4006 1269246 A methoxyflavone. YNL221C POP1
SGTC_2651 TUB2.036 5 µM -0.949394898257576 0.192053379894982 no 2752 0.171209902071354 4019 15992207 YFL037W TUB2
SGTC_647 0140-0236 81 µM -0.950438393499698 0.191779776708569 no 2753 0.170944771662911 4030 990837
SGTC_2275 7947463 200 µM -0.952013952223446 0.191367119612902 no 2754 0.170544953010803 4021 1225414
SGTC_54 0159-0055 9 µM -0.952546553394552 0.191227748347731 no 2755 0.170409934012329 4027 3319099
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.953310245583668 0.191028013714991 no 2756 0.170216450943038 4016 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3272 9137413 49.47 µM -0.954920509847132 0.190607287704836 no 2757 0.169808948485505 3960 17614870
SGTC_2545 solidagenone 89.61 µM -0.956458190044002 0.190206057668947 no 2758 0.16942039898136 3842 6708572 An anti ulcer agent
SGTC_321 4534-3890 65.3 µM -0.957713513029788 0.1898788887146 no 2759 0.169103620423121 4052 699746
SGTC_2943 9068529 45.32 µM -0.961714054006248 0.188838556830827 no 2760 0.168096630368844 4031 3270634
SGTC_2245 6637752 200 µM -0.962128514725947 0.188730978390413 no 2761 0.167992526057291 4117 681890
SGTC_874 0599-0792 117 µM -0.963602486458441 0.188348696814848 no 2762 0.167622629878191 4073 765305
SGTC_3343 9148379 18.9835 µM -0.964657636521793 0.188075332203034 no 2763 0.167358160267381 4089 1955036
SGTC_539 4859-0462 2.54 µM -0.965206731829106 0.187933171428418 no 2764 0.167220637919491 4106 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_222 nsc-310342 10.666 µM -0.966259849600377 0.187660704943901 no 2765 0.166957085727952 4018 432556
SGTC_3110 9122132 49.47 µM -0.967700865265408 0.187288275753257 no 2766 0.166596892935666 4154 918317
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.967904085089075 0.187235790566036 no 2767 0.166546136982258 4054 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_32 0928-0142 34.1 µM -0.968392370938173 0.187109719117223 no 2768 0.166424224069354 4036 2244242
SGTC_742 0kpi-0133 140 µM -0.968754917329164 0.187016146550366 no 2769 0.166333742474734 4107 2728852
SGTC_1374 2889-5571 141 µM -0.96910860212837 0.186924889046277 no 2770 0.166245503107166 4114 2853281
SGTC_2196 6573537 42.6665 µM -0.969221063334197 0.186895877659282 no 2771 0.166217451959242 4079 2903087
SGTC_1396 3511-0007 98.6 µM -0.969654394970064 0.186784118038199 no 2772 0.166109394831427 4055 X1396
SGTC_3130 9127414 49.47 µM -0.970440193343602 0.186581560028575 no 2773 0.165913561132124 4068 1494646
SGTC_3172 9105863 49.47 µM -0.971145585413291 0.186399844536708 no 2774 0.165737893136684 4074 2348785
SGTC_918 glabranin 770.725 nM -0.971476945757585 0.186314520919477 no 2775 0.16565541402118 4066 124049 Also referred to as licorice root.
SGTC_3063 1327-0034 4 µM -0.973768930635028 0.185725009139955 no 2776 0.165085641471889 3959 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3059 1327-0034 3 µM -0.975112993853451 0.185379847148033 no 2777 0.164752106932612 3952 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2331 7980721 200 µM -0.975529048911878 0.185273082946748 no 2778 0.164648949785819 4031 2981221
SGTC_1140 3229-1848 2.98 µM -0.975851456751908 0.18519037589149 no 2779 0.164569040420421 4087 2849525
SGTC_1826 st055655 41.6 µM -0.976395037167006 0.185050983522587 no 2780 0.164434369951552 4087 676168
SGTC_1065 prochlorperazine maleate 2.48 µM -0.976560579955841 0.185008545714298 no 2781 0.16439337140092 4103 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2792 7535235 81.82 µM -0.9768961529716 0.184922538272141 no 2782 0.164310283268482 4068 1281891
SGTC_623 k072-0108 16.9 µM -0.977557316641427 0.184753154586506 no 2783 0.164146658331517 4026 5382803
SGTC_1928 4'-methoxychalcone 40.3 µM -0.979808059485989 0.184177259564313 no 2784 0.163590436523609 4107 641818
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.97993164091313 0.184145671315842 no 2785 0.163559931564231 4071 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2180 6301957 200 µM -0.982564800554507 0.183473419501845 no 2786 0.162910837781724 4086 845462
SGTC_3312 9133330 71.43 µM -0.982710725904419 0.183436209210681 no 2787 0.162874915126224 4115 17617324
SGTC_3123 9126162 49.47 µM -0.982737154278611 0.183429470600357 no 2788 0.162868409765859 4128 25239884
SGTC_2563 tomatine 8.54 µM -0.983449482272251 0.183247901947523 no 2789 0.162693133445799 3959 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2826 7992541 19.48 µM -0.984100963843264 0.183081940894958 no 2790 0.16253293653827 4088 2985066
SGTC_1728 st035614 33.7865 µM -0.98461708706929 0.182950528166076 no 2791 0.162406096637411 4045 15945546
SGTC_827 3253-0474 693 µM -0.985548221577809 0.182713596258866 no 2792 0.162177428609476 4118 5402065
SGTC_1475 4092-1048 11.7 µM -0.987106913351928 0.182317408197409 no 2793 0.161795114490779 4098 2881759
SGTC_2349 9023730 187.07 µM -0.988185279406647 0.182043623668865 no 2794 0.161530958098704 4094 4126287
SGTC_964 1287-0107 19.4 µM -0.98834968355391 0.182001905972448 no 2795 0.161490710398347 4096 51516812 YPR165W RHO1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.989030951726512 0.181829097293746 no 2796 0.161323999158136 4009 1241132 A phosphatase inhibitor.
SGTC_3309 9129340 25.759 µM -0.98974501389183 0.181648080379942 no 2797 0.161149383520696 4090 17158987
SGTC_1392 3455-1037 33.9 µM -0.990286160692723 0.181510973170867 no 2798 0.161017134504988 4088 981132
SGTC_3329 9141233 27.5565 µM -0.990390622763458 0.181484513686135 no 2799 0.160991613535483 4055 4909101 YNL103W MET4
SGTC_1142 3253-1408 9.78 µM -0.990646915680009 0.181419606778664 no 2800 0.160929010188284 4082 256655
SGTC_2761 levamisole 97.89 µM -0.994331939926051 0.180487971165632 no 2801 0.160030645398573 4048 26879 An alkaline phosphatase inhibitor.
SGTC_1815 st051655 58.2 µM -0.994580641827812 0.180425203464475 no 2802 0.159970133210099 4044 5984156
SGTC_2221 6807166 181.081 µM -0.99556450778743 0.18017702839486 no 2803 0.159730893404475 4031 674925
SGTC_1571 st070080 73.4 µM -0.996368334509677 0.179974426408974 no 2804 0.159535606333097 4123 4315245
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.99647849171678 0.179946672782951 no 2805 0.159508856181013 4094 688669
SGTC_3171 9103192 49.47 µM -1.00059684502278 0.178911000811467 no 2806 0.158510878006755 4129 13018434
SGTC_1515 3460-0031 42.1 µM -1.00355124932017 0.178170351146781 no 2807 0.15779748134868 4026 2876596
SGTC_2234 tolnaftate 200 µM -1.00406164890616 0.178042593394899 no 2808 0.157674449691942 4109 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2024 5144227 134 µM -1.00436888691115 0.177965716727376 no 2809 0.157600420461404 4149 3475211
SGTC_1310 1188-0297 994 nM -1.00499368978203 0.177809443998079 no 2810 0.157449944188782 3979 1588352
SGTC_3101 9120531 49.47 µM -1.00767725822353 0.177139227322572 no 2811 0.156804713039648 4119 24824904
SGTC_1620 st003704 16.5 µM -1.00812118737365 0.177028510790537 no 2812 0.156698143681525 4046 2834414
SGTC_1261 0712-0010 12.7 µM -1.00888832537585 0.176837288617697 no 2813 0.156514097400145 4136 2840123
SGTC_1106 tegaserod maleate 11.7 µM -1.0099457203614 0.176573929050721 no 2814 0.156260648124686 4106 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1074 carmofur 3.8 µM -1.01067917135682 0.176391398211424 no 2815 0.156085004578734 4143 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1842 st055362 61.2 µM -1.01248161435567 0.175943339231297 no 2816 0.15565391656838 4074 676032
SGTC_1907 st060210 83.7 µM -1.0126415090547 0.175903626757031 no 2817 0.15561571271149 4146 688793
SGTC_3046 9092212 49.47 µM -1.01922892530472 0.174272469996889 no 2818 0.154047148725122 4161 25236637
SGTC_107 0358-0022 2.6945 µM -1.0197822579737 0.174135894332207 no 2819 0.153915869698314 4143 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1395 3486-0190 4.35 µM -1.02074821493429 0.173897636270392 no 2820 0.153686872407954 4093 6748079
SGTC_3163 9099914 49.47 µM -1.0235178470382 0.17321564280193 no 2821 0.153031532994128 4116 16268368
SGTC_2923 7992654 58.14 µM -1.023984170482 0.173100983196373 no 2822 0.152921375855208 4122 2985126
SGTC_2108 5365811 200 µM -1.02534264180299 0.172767237905886 no 2823 0.152600771046054 4122 780283
SGTC_106 0092-0003 11.579 µM -1.02551552857496 0.172724793025313 no 2824 0.152560001069351 4024 1072148
SGTC_2397 5161689 200 µM -1.02620953028864 0.172554477780022 no 2825 0.152396415055111 4195 2259942
SGTC_1767 st044992 70.3 µM -1.02625876068202 0.17254240019813 no 2826 0.152384815179319 4155 9600693
SGTC_429 1112-0049 25.5 µM -1.03090567279484 0.171404811050201 no 2827 0.151292528065045 4092 2836170
SGTC_162 k030-0015 37.8 µM -1.0310919535672 0.171359308675371 no 2828 0.151248850383372 4209 1809920 YMR134W ERG29
SGTC_1257 0669-0121 16 µM -1.03195066517345 0.17114965302138 no 2829 0.151047614756075 4146 4307855
SGTC_485 niflumic acid 177 µM -1.03246600889764 0.171023909919459 no 2830 0.150926931602504 4181 4488 A COX2 inhibitor.
SGTC_3239 9133757 49.47 µM -1.03522432954893 0.170351888746949 no 2831 0.150282079568713 4148 17036923
SGTC_145 3737-0113 38.366 µM -1.03620866724411 0.170112480512199 no 2832 0.150052402066302 4084 6849351
SGTC_2179 6298986 200 µM -1.03638539352908 0.170069520414678 no 2833 0.150011190958688 4112 738374
SGTC_2249 haloperidol 116.36 µM -1.03661425531008 0.170013897120263 no 2834 0.14995783350031 4115 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3211 9128781 49.47 µM -1.03891831992067 0.16945455969703 no 2835 0.149421362710811 4140 17194361
SGTC_496 calpeptin 138 µM -1.03934186354442 0.169351868384316 no 2836 0.149322885780562 4145 73364 A calpain inhibitor.
SGTC_102 gallobenzophenone 83.616 µM -1.04298320126039 0.168470647270268 no 2837 0.148478036537147 4145 70837
SGTC_2097 5376186 200 µM -1.04436131991264 0.168137906451793 no 2838 0.148159126154031 4110 742755
SGTC_2992 9074591 71.4286 µM -1.04460834610213 0.168078307762189 no 2839 0.148102010310665 4097 17741321
SGTC_83 0170-0301 39.027 µM -1.04521534551828 0.167931918005384 no 2840 0.147961726314119 4138 3089716
SGTC_588 3970-1144 52.9 µM -1.04685065279338 0.1675379402644 no 2841 0.147584232205922 4016 1888707
SGTC_538 2922-0838 53.3 µM -1.04821141260959 0.16721056066712 no 2842 0.147270606783001 4159 777039
SGTC_79 0052-0007 94.094 µM -1.04877175850452 0.167075869308988 no 2843 0.147141589234737 4151 2801472
SGTC_1128 3448-9350 235 µM -1.04885854716085 0.167055014020996 no 2844 0.147121613250174 4199 619386
SGTC_273 hydroxyurea 18.1 mM -1.05044424508066 0.166674266833358 no 2845 0.146756956183668 4216 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2984 9022109 38.96 µM -1.05118734071158 0.166496032535064 no 2846 0.146586278088242 4163 6459207
SGTC_928 2764-0428 58.7 µM -1.05329179221884 0.165991939782907 no 2847 0.146103639755582 4174 662578
SGTC_2074 5212007 75.395 µM -1.05335910013773 0.165975833379102 no 2848 0.146088220885116 4021 758611
SGTC_2832 7992762 51.95 µM -1.05523466669014 0.165527427125682 no 2849 0.14565900647781 4086 2985177
SGTC_698 k064-0052 127 µM -1.05588924878911 0.165371115729333 no 2850 0.145509408288684 4228 5088751
SGTC_68 0986-0284 82.829 µM -1.05698180948509 0.165110429730955 no 2851 0.145259944706502 4208 423278 YIL048W NEO1
SGTC_639 0833-0042 114 µM -1.05773577848708 0.164930687243593 no 2852 0.145087959422379 4145 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1328 1441-0025 69.2 µM -1.05782362009491 0.164909754482437 no 2853 0.145067931091755 4119 4562601
SGTC_442 cape 100 µM -1.05922227938819 0.164576684098749 no 2854 0.144749280407806 4145 5281787
SGTC_2452 5863136 48.41 µM -1.0638709121404 0.1634728144211 no 2855 0.14369359087595 4108 2184096
SGTC_2625 euphol 100 µM -1.06398718471752 0.163445265984892 no 2856 0.143667252522205 4192 6708538 A triterpene alcohol.
SGTC_2306 7482397 179.52 µM -1.0641003718702 0.163418451474123 no 2857 0.143641616216128 4167 891448
SGTC_3337 9144342 33.5465 µM -1.0661605970773 0.16293087487884 no 2858 0.143175525355154 4161 17682949
SGTC_2333 9017922 200 µM -1.07094164459919 0.161803031772421 no 2859 0.142097834643119 4202 3163164
SGTC_1018 4259-0013 28.1 µM -1.07180857908869 0.161599069187165 no 2860 0.14190300947742 4230 6801262
SGTC_431 k089-0097 107 µM -1.07213582139594 0.161522122894166 no 2861 0.141829515742334 3972 5499420
SGTC_1650 st011916 45.8 µM -1.07273652153239 0.161380939130825 no 2862 0.14169467455887 4091 242528
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.07373334782858 0.161146830682787 no 2863 0.141471105268761 4221 23847180
SGTC_2927 9011802 47.9 µM -1.07378980410716 0.16113357834454 no 2864 0.141458450349499 4182 43912568
SGTC_569 4130-2812 160 µM -1.07402343150307 0.161078745073133 no 2865 0.141406089913061 3976 743552
SGTC_2512 diallyl trisulfide 49.23 µM -1.07461324798103 0.160940367000099 no 2866 0.141273959031849 4189 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_992 3909-8734 162 µM -1.07499488940227 0.160850870670774 no 2867 0.141188508207676 4188 4288319
SGTC_1546 5-methoxyflavanone 78.7 µM -1.07855589548011 0.160017367817297 no 2868 0.140392875769423 4166 147795
SGTC_1825 st052143 62.6 µM -1.07886117843149 0.159946043787837 no 2869 0.140324808636326 4229 674173
SGTC_625 k213-0058 121 µM -1.07936150404645 0.159829196414635 no 2870 0.140213302464563 4226 3655420
SGTC_426 0988-0037 14.6 µM -1.08006669306773 0.159664599540554 no 2871 0.140056241178686 4219 5383008
SGTC_1138 3761-0006 1.03 µM -1.08072899912091 0.159510112946366 no 2872 0.139908839778047 4206 12061087
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.08227742495356 0.159149315862725 no 2873 0.139564636988931 4269 688801
SGTC_3347 9188721 44.724 µM -1.08491515484279 0.158535933100101 no 2874 0.138979617598141 4193 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_902 1120-0002 2.07 µM -1.08769827533765 0.157890424132834 no 2875 0.138364164683936 4163 3280475
SGTC_2035 5154463 94.595 µM -1.08776761122583 0.1578743646317 no 2876 0.138348855657342 4197 2769623
SGTC_2098 5376439 882.5 nM -1.09097033567687 0.15713372231673 no 2877 0.137642967869624 4222 2844116
SGTC_2905 7799065 20.05 µM -1.09172817141568 0.15695880474982 no 2878 0.137476299415656 4090 1296806
SGTC_2830 7992007 71.43 µM -1.091863780587 0.156927518045399 no 2879 0.137446489852639 4062 1952075
SGTC_2396 5342950 42.78 µM -1.09483162053905 0.156243828381871 no 2880 0.13679520531815 4165 1886677
SGTC_2465 5809242 33.21 µM -1.09489383802468 0.156229516614716 no 2881 0.136781574471662 4235 2731748
SGTC_1997 st073024 93.8 µM -1.09512976102512 0.156175255552654 no 2882 0.13672989598743 4193 686268
SGTC_3160 9100216 49.47 µM -1.09812491190279 0.155487466008154 no 2883 0.136074974297728 4156 17191039
SGTC_316 k060-0003 58.6 µM -1.09835507283353 0.155434695959636 no 2884 0.136024736148144 4228 6152314
SGTC_420 mitomycin C 81.9 mM -1.09938672681023 0.155198309144263 no 2885 0.135799708911937 4179 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2930 9013230 14.89 µM -1.1010632087655 0.154814676857028 no 2886 0.13543457403759 4209 2995857
SGTC_961 1252-1571 372 µM -1.10180112206507 0.154646017592566 no 2887 0.135274071235398 4215 6813498
SGTC_2009 4012297 12.05 µM -1.1022979584631 0.154532527877433 no 2888 0.135166078315626 4187 45595307
SGTC_2240 6690706 185.951 µM -1.10294126917961 0.154385661614343 no 2889 0.13502633541628 4065 805876
SGTC_598 3937-0236 20.2 µM -1.10309602086392 0.154350345957834 no 2890 0.134992734336696 4262 1379313
SGTC_826 1683-5028 118 µM -1.10374160377922 0.154203076047146 no 2891 0.134852621428288 4244 722377
SGTC_1760 st045453 10.4495 µM -1.10412283222236 0.154116154146956 no 2892 0.134769929079433 4244 3323419 YIL048W NEO1
SGTC_3051 9093778 49.47 µM -1.10791591385513 0.15325307927552 no 2893 0.13394906607005 4259 17217378
SGTC_2062 5245942 200 µM -1.10824843015909 0.153177571753498 no 2894 0.133877270174365 4246 1376160
SGTC_1343 1487-0095 224 µM -1.10957273267351 0.152877094917711 no 2895 0.133591593306226 4212 4560101 YGL055W OLE1
SGTC_2185 6113692 200 µM -1.10966388138405 0.152856428170942 no 2896 0.133571946251749 4216 874150
SGTC_571 k831-0106 44.2 µM -1.11031439913277 0.15270898579814 no 2897 0.13343178520331 4064 4783639
SGTC_833 3852-0053 558 µM -1.11300030773834 0.152101213335564 no 2898 0.132854148660493 4277 3123681
SGTC_2326 6164455 177.58 µM -1.11362772938549 0.151959470950231 no 2899 0.13271946265059 4170 2888790
SGTC_204 PMA1.184 62.41 µM -1.11412654492585 0.151846844918687 no 2900 0.13261245110838 4198 2252213 YGL008C PMA1
SGTC_255 tunicamycin 200.472 nM -1.11805698845874 0.150961342708515 no 2901 0.131771327383263 4128 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1644 st010134 20.9 µM -1.12071020574086 0.150365537775154 no 2902 0.131205618291683 4192 3818134
SGTC_2544 sphondin 68.51 µM -1.12164257558562 0.150156537890627 no 2903 0.131007220752446 4207 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1391 3442-0225 151 µM -1.12215081954892 0.150042691585607 no 2904 0.130899159637675 4183 5227075
SGTC_1039 k821-0043 94 µM -1.12269117687413 0.149921715043479 no 2905 0.130784338263193 4216 15992768
SGTC_2486 5283202 22.39 µM -1.12576785624407 0.149234140257537 no 2906 0.130131896596398 4259 1377751
SGTC_3225 9130819 49.47 µM -1.12750461887773 0.148846940664402 no 2907 0.129764594375775 4163 4547121
SGTC_1534 6-azauridine 81.6 µM -1.12937732910261 0.148430185331126 no 2908 0.129369346156972 4256 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1301 naphtanilide LB 4.81 µM -1.13080326170404 0.1481133802788 no 2909 0.129068953406053 4286 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3073 9114972 49.47 µM -1.13408763581092 0.14738540050186 no 2910 0.128378894732116 4224 41905075
SGTC_2816 7982706 58.44 µM -1.13471200519233 0.147247281052361 no 2911 0.12824800278578 4246 2981853
SGTC_129 0088-0017 176.636 µM -1.13620538471567 0.146917276138346 no 2912 0.127935308735682 4107 182446
SGTC_361 000s-0510 1.45 µM -1.13904192787429 0.146291827690939 no 2913 0.127342833446665 4161 660
SGTC_1920 st075728 45.7 µM -1.1391424352832 0.14626969898561 no 2914 0.127321875300419 4216 3400306
SGTC_1377 2944-0135 198 µM -1.14284786912768 0.145455442961225 no 2915 0.126550879984111 4255 1894137
SGTC_590 k048-0076 22.4 µM -1.14316985673917 0.14538483156733 no 2916 0.126484037430429 4255 6832814
SGTC_329 k048-0121 21.3 µM -1.1488045673254 0.144152880378928 no 2917 0.125318287820242 4249 6832902
SGTC_2018 5133068 143 µM -1.15008894055777 0.143873057932663 no 2918 0.125053620487238 4192 785362
SGTC_3012 9080433 71.4286 µM -1.15095719790042 0.143684101091582 no 2919 0.124874922356998 4249 17688859
SGTC_2771 fluoxetine 41.05 µM -1.15161470477707 0.143541120866534 no 2920 0.12473971804933 4257 3386 A selective serotonin reuptake inhibitor.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.15265080494306 0.143316007420219 no 2921 0.124526870614109 4287 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1606 st000094 49.2 µM -1.15332167710179 0.143170374278567 no 2922 0.124389187959561 4271 1242210
SGTC_984 1492-0255 2.91 µM -1.15569384251324 0.142656225714667 no 2923 0.12390320383696 4220 1585198
SGTC_3148 9097893 49.47 µM -1.15625619780777 0.142534522825702 no 2924 0.123788189568478 4213 17174100
SGTC_1180 1193-0155 285 µM -1.15754181127803 0.142256558850769 no 2925 0.123525533584847 4320 2921347
SGTC_2202 7226349 200 µM -1.15951152585911 0.141831396499223 no 2926 0.123123870584375 4210 844334
SGTC_2652 actinonin 100 µM -1.16394652544862 0.140877255700825 no 2927 0.122222841631738 4279 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1632 st005650 90 µM -1.1643751590392 0.140785271264057 no 2928 0.122136004988565 4283 2759605
SGTC_207 4185-0010 4.486 µM -1.1651023621269 0.140629307280571 no 2929 0.12198878042369 4327 3761753
SGTC_128 0906-2981 13.371 µM -1.16517436343034 0.140613871470741 no 2930 0.121974210316358 4241 6740226
SGTC_714 4296-0578 26.1 µM -1.17028353575782 0.139521490377678 no 2931 0.120943442649412 4307 1589775
SGTC_2391 6285546 200 µM -1.17035195311264 0.139506901481228 no 2932 0.120929681268652 4256 846083
SGTC_1675 st018485 24.5 µM -1.17190520213753 0.139175975343425 no 2933 0.120617559126445 4288 3323024
SGTC_829 1635-0120 117 µM -1.17198216534134 0.139159591917236 no 2934 0.120602108293672 4263 285054
SGTC_2139 5578692 56.4705 µM -1.17505781607333 0.138505941601523 no 2935 0.119985792916058 4228 650991 YMR113W FOL3
SGTC_1883 5-benzylidenerhodanine 20 µM -1.17954574108501 0.137555907804012 no 2936 0.119090467012288 4246 1273210
SGTC_1951 sophoraflavanone G 9.2 µM -1.18002364435621 0.137455004753519 no 2937 0.118995405530363 4230 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1316 1272-0050 65.9 µM -1.18085507564082 0.137279579329955 no 2938 0.1188301502236 4224 7340392
SGTC_2616 abietic acid 100 µM -1.18111201594109 0.137225397900922 no 2939 0.118779113565367 4312 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2207 7258803 200 µM -1.18137376304803 0.137170217873202 no 2940 0.118727138043061 4265 3666799
SGTC_76 0433-0009 400.328 µM -1.18144119317237 0.137156005095806 no 2941 0.118713750943568 4338 2841569
SGTC_3222 9128301 49.47 µM -1.1830249422716 0.136822475128423 no 2942 0.118399631232708 4269 4911358
SGTC_2565 isoliquiritigenin 100 µM -1.18584052074262 0.136230897674071 no 2943 0.117842642969913 4354 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1781 st038725 66.3 µM -1.18721714768625 0.135942294439771 no 2944 0.117570989375647 4270 4270275 YIL048W NEO1
SGTC_805 3852-0218 479 µM -1.18747598294904 0.135888077655964 no 2945 0.117519962251203 4238 6615355
SGTC_443 clozapine 122 µM -1.18879545511274 0.135611925288392 no 2946 0.117260083465658 4234 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2636 apigenin dimethyl ether 100 µM -1.18879669731964 0.135611665488151 no 2947 0.117259838996721 4264 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_812 4251-0442 148 µM -1.18958384948266 0.13544710582357 no 2948 0.117104998381391 4298 5723007
SGTC_1283 0922-0125 16.4 µM -1.19131193116095 0.135086318398711 no 2949 0.116765575881178 4269 3360884
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.19343742244942 0.134643464652976 no 2950 0.11634905311931 4328 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1477 0139-0234 16 µM -1.19643888060422 0.134019798689509 no 2951 0.115762668139748 4284 620880
SGTC_1512 0259-0544 12.2 µM -1.19675149363846 0.133954955879182 no 2952 0.115701714866336 4256 18476
SGTC_3147 9097027 49.47 µM -1.2012487493827 0.13302451192572 no 2953 0.114827362162983 4272 25236841
SGTC_1905 st060207 84.5 µM -1.20236149526609 0.132794982473208 no 2954 0.114611750329871 4274 1948547
SGTC_542 3381-0244 89.3 µM -1.20663428766717 0.131916155845381 no 2955 0.113786508001106 4306 1112843
SGTC_848 0368-0089 85.6 µM -1.20822938041716 0.131589108328367 no 2956 0.11347952178055 4284 762535
SGTC_4 0960-0234 25.671 µM -1.20828887305845 0.131576921176189 no 2957 0.11346808346152 4304 6821112
SGTC_2568 diosmetin 100 µM -1.20864177295624 0.131504645146768 no 2958 0.11340025026551 4340 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2795 7780010 54.55 µM -1.20888914566271 0.131453998064438 no 2959 0.113352718386044 4258 953673
SGTC_1453 4237-0541 195 µM -1.21055329140201 0.131113630916313 no 2960 0.113033327401791 4296 739892
SGTC_894 0960-0238 55.9 µM -1.21152304279317 0.130915568986542 no 2961 0.112847504420907 4301 6741907 YDL195W SEC31
SGTC_425 3825-7017 13.1 µM -1.21586363273187 0.13003158168924 no 2962 0.112018436877546 4347 3397440
SGTC_999 SEC7.066 22.7 µM -1.21609630217698 0.129984314100146 no 2963 0.111974119512709 4256 740511 YDR170C SEC7
SGTC_3308 9128332 17.569 µM -1.21753443701917 0.129692416080017 no 2964 0.111700471134542 4293 17332805 YDL196W YDL196W
SGTC_1151 3909-8316 15.3 µM -1.21894139918928 0.129407284811904 no 2965 0.111433217576325 4338 800431
SGTC_308 4092-1169 104 µM -1.22472568118276 0.128239622759812 no 2966 0.110339297339507 4253 2268590 YDL196W YDL196W
SGTC_2787 5284540 71.43 µM -1.22676427784768 0.127829844163263 no 2967 0.109955600363085 4335 736958
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.22828786474027 0.127524182535568 no 2968 0.109669462418115 4306 5379071
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.22852286826339 0.127477081463651 no 2969 0.109625375103009 4331 5106787 A p450 inhibitor.
SGTC_3070 9117005 49.47 µM -1.22977215595462 0.127226893470242 no 2970 0.109391218878755 4395 8779016
SGTC_320 4092-0846 5.34 µM -1.22990149656112 0.127201010664281 no 2971 0.109366996875567 4266 1359356
SGTC_219 mitoxanthrone 164.414 µM -1.2312132323225 0.126938721554447 no 2972 0.109121561828563 4234 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1016 4226-1401 38 µM -1.23518057131999 0.126147721396589 no 2973 0.108381654179213 4299 2901613
SGTC_3315 9136395 68.55 µM -1.23851430319318 0.125485710336524 no 2974 0.107762710947553 4301 16876844
SGTC_1765 st044815 90.4 µM -1.23886206516398 0.125416791828707 no 2975 0.10769829214765 4343 645695
SGTC_710 3448-4187 58 µM -1.2395779133291 0.125275010190528 no 2976 0.107565777064777 4293 3946412
SGTC_1923 st058458 19.1 µM -1.23992517930281 0.125206270653381 no 2977 0.107501534852781 4324 3534982
SGTC_2433 5607874 27.82 µM -1.2419570263962 0.124804604701394 no 2978 0.107126208956294 4274 2252428
SGTC_1124 fisetin 1.16336 µM -1.24737042182786 0.123738855000299 no 2979 0.106130853375792 4334 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_193 1273-0060 1.558 µM -1.24792701540946 0.123629639258058 no 2980 0.106028893115841 4161 2847393 YHR072W ERG7
SGTC_3204 9114183 49.47 µM -1.24859350532779 0.123498948302481 no 2981 0.105906894505805 4300 17027248
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.24952362931548 0.12331672355886 no 2982 0.105736808243776 4287 676296 Flavone; oxidizing agent.
SGTC_1114 scopoletin 1.73284 µM -1.25350948002888 0.122537971478119 no 2983 0.105010175599885 4349 5280460 A coumarin with genotoxic properties.
SGTC_470 aa-861 153 µM -1.2554515442152 0.122159785470747 no 2984 0.104657443946452 4280 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1927 st060202 13.8 µM -1.25560418583244 0.12213009572652 no 2985 0.104629756498714 4255 688887
SGTC_2723 salbutamol 83.58 µM -1.25611811252095 0.122030171036214 no 2986 0.104536575065625 4327 9884233 β2-adrenoceptor agonist
SGTC_2189 6047310 154.431 µM -1.25632212606269 0.121990519843995 no 2987 0.10449960149513 4299 711535
SGTC_1300 1094-0077 113 µM -1.2568675635614 0.12188455540185 no 2988 0.104400797860234 4296 5532636
SGTC_450 aminopyrene 156 nM -1.25796419560877 0.121671703793477 no 2989 0.104202352631626 4287 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2099 5377090 177.372 µM -1.26020397987513 0.121237783118504 no 2990 0.103797893761851 4354 2243829
SGTC_581 0958-0271 211 µM -1.2614702474285 0.120992947127187 no 2991 0.103569736460207 4339 4591145
SGTC_2077 5212015 200 µM -1.26548913906876 0.120218189322578 no 2992 0.102848019649697 4239 780900
SGTC_301 4119-0100 24.5 µM -1.26675450505318 0.11997497847388 no 2993 0.102621542071403 4371 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1727 st034309 9.9045 µM -1.26695987373679 0.119935538130538 no 2994 0.102584819017881 4399 870305
SGTC_1355 1499-0035 1.68 µM -1.26712129994778 0.119904543202881 no 2995 0.10255596025508 4345 1548538
SGTC_3159 9100096 49.47 µM -1.26727036774956 0.119875926188932 no 2996 0.102529316092815 4282 25236875
SGTC_2132 5317594 122.667 µM -1.26774913379099 0.119784048536806 no 2997 0.10244377618413 4276 794577
SGTC_3175 9106517 49.47 µM -1.26836959449814 0.119665052840777 no 2998 0.102332997266824 4347 41468073
SGTC_2128 5255449 168.493 µM -1.27114435664071 0.119133912424267 no 2999 0.101838648841579 4271 736008
SGTC_916 4466-0038 42 nM -1.27239889245785 0.118894318367004 no 3000 0.101615713698465 4402 5722064 YGL116W CDC20
SGTC_1174 0739-0097 51.1 µM -1.27390381688884 0.118607353754948 no 3001 0.101348752772392 4386 728447
SGTC_1429 4049-0205 9.46 µM -1.27599660468358 0.118209107206263 no 3002 0.100978359666436 4377 22774478
SGTC_2037 5169046 200 µM -1.27609961174503 0.118189529946916 no 3003 0.100960154423545 4397 5718022
SGTC_46 0329-0187a 2.197 µM -1.27777523844359 0.11787138657297 no 3004 0.100664343798466 4385 46494817
SGTC_2294 7971431 200 µM -1.28035705740347 0.117382375614135 no 3005 0.100209794674746 4344 5741572
SGTC_1342 1486-1464 234 µM -1.28108262486519 0.117245208051813 no 3006 0.100082323038424 4384 3253938
SGTC_661 1304-0007 33.6 µM -1.28295982083123 0.11689085362918 no 3007 0.0997530765127359 4356 3117130
SGTC_2949 9072542 2.23 µM -1.28561727092481 0.116390511205828 no 3008 0.0992883330994413 4362 16457352
SGTC_502 l-744,832 89.3 µM -1.28679087807627 0.116170029799088 no 3009 0.099083593614845 4362 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1221 2958-7315 257 µM -1.28699309926175 0.116132069180497 no 3010 0.0990483466984017 4376 4562705
SGTC_2457 5731572 11.68 µM -1.29310814136386 0.114988319726904 no 3011 0.0979868298711208 4409 2865357
SGTC_75 0159-0059 199.013 µM -1.2946784455125 0.114695909235131 no 3012 0.0977155892809896 4435 5377270
SGTC_1387 3342-1166 1.8 µM -1.30220727231106 0.113301296426347 no 3013 0.0964227699209217 4341 3418228
SGTC_620 0109-0052 432 µM -1.30670693532498 0.112473592457694 no 3014 0.0956561311874413 4407 493037
SGTC_1088 bifonazole 369 nM -1.31129084108524 0.111634843111641 no 3015 0.0948797607713891 4358 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3268 9137683 49.47 µM -1.31267878705145 0.111381765761398 no 3016 0.0946456042797347 4452 1953228
SGTC_1090 efavirenz 20.7 µM -1.31520057247104 0.110922996120915 no 3017 0.0942212514105607 4404 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1710 st031758 61.5 µM -1.31535839210602 0.110894330243683 no 3018 0.0941947410866289 4414 5394341
SGTC_534 k292-0788 63.4 µM -1.32033506029919 0.109993104206203 no 3019 0.0933615873867705 4420 4146317
SGTC_3352 9151559 45.5865 µM -1.32077255672826 0.10991412990198 no 3020 0.0932886064084835 4394 17159339
SGTC_888 0916-0002 6.97 µM -1.32181716516753 0.109725727869996 no 3021 0.0931145205110454 4420 2802138 YIL048W NEO1
SGTC_1264 0783-0040 158 µM -1.32446507369136 0.109249198955331 no 3022 0.092674317571763 4297 2855798
SGTC_1731 st035964 63 µM -1.32807100787797 0.10860265341699 no 3023 0.0920773250586201 4302 6739575
SGTC_2356 9061756 188.97 µM -1.32929787336964 0.108383304656399 no 3024 0.0918748578059248 4428 20104043
SGTC_2351 9026858 72.31 µM -1.33200261624045 0.107900855734792 no 3025 0.0914296644059408 4289 1409300
SGTC_369 0957-0393 4.5 µM -1.3389602605914 0.106666921585412 no 3026 0.0902918051257245 4392 6997992
SGTC_2482 5981709 142.65 µM -1.34306788415205 0.105943235414885 no 3027 0.0896249968325603 4337 877755
SGTC_3193 9111931 49.47 µM -1.34437807789893 0.105713151950803 no 3028 0.0894130795327798 4387 17087244
SGTC_897 1000-0139 31.4 µM -1.34610234360982 0.105410904047715 no 3029 0.0891347564746015 4361 6151020
SGTC_2429 5902844 64.44 µM -1.35004847852327 0.104721536310835 no 3030 0.0885002165449594 4389 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_110 0850-0284 111.64 µM -1.35066886967821 0.104613455127071 no 3031 0.0884007643197887 4288 3906265
SGTC_1774 st048371 48.465 µM -1.35530291635693 0.103808691737554 no 3032 0.0876605331162275 4385 4242727
SGTC_220 paclitaxel 373.376 µM -1.35769568908036 0.103394917498321 no 3033 0.0872801326349421 4375 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1647 st011722 22.4 µM -1.36020738293542 0.102961867961091 no 3034 0.0868821534527209 4380 2854783
SGTC_920 mycophenolic acid 780.421 nM -1.36040813407278 0.102927312736012 no 3035 0.0868504029395632 4384 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2952 9073731 13.78 µM -1.3615207564223 0.102735950170719 no 3036 0.0866745893321202 4412 16457353
SGTC_1035 k081-0041 55.2 µM -1.36227305348556 0.102606707409009 no 3037 0.0865558641802083 4422 731709
SGTC_430 0958-0115 16.4 µM -1.36295977175675 0.102488834139555 no 3038 0.0864475946398307 4333 6833180
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.36827666703691 0.101579534651154 no 3039 0.0856127457459889 4416 551469
SGTC_645 0845-0943 5.41 µM -1.37240322044138 0.100877868115595 no 3040 0.0849689740720212 4427 1885106
SGTC_585 0kpi-0023 191 µM -1.37832126199441 0.099877760403685 no 3041 0.0840520607218647 4352 64601
SGTC_1859 st055998 20 µM -1.37932985346871 0.0997080402738227 no 3042 0.0838965380373235 4359 676301
SGTC_2247 cerulenin 830 nM -1.38200752565976 0.0992584790431966 no 3043 0.0834846951920802 4446 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_867 0518-0118 155 µM -1.38224032654926 0.0992194636483607 no 3044 0.0834489608663456 4416 6848158
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.38438280748676 0.0988609289496011 no 3045 0.0831206352171 4415 689007
SGTC_658 3253-0951 102 µM -1.38685310109303 0.0984487139615561 no 3046 0.0827432805772373 4439 1184878
SGTC_1645 Cervolide 78 µM -1.39022671048275 0.0978877986844753 no 3047 0.0822300224669343 4437 23173 A fragrance.
SGTC_2285 7945142 200 µM -1.39158561150531 0.0976625231615509 no 3048 0.0820239592201742 4448 2970608
SGTC_2426 5582046 32.21 µM -1.39209118402265 0.0975788075941444 no 3049 0.0819473937726045 4423 2251934
SGTC_649 1123-0311 367 µM -1.39563693202296 0.0969931608355659 no 3050 0.0814119275171977 4336 693629 YIL048W NEO1
SGTC_917 harmaline 728.087 nM -1.39606444423568 0.096922723854416 no 3051 0.0813475448304289 4368 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1208 2323-2347 50.3 µM -1.39786531310328 0.0966264246818633 no 3052 0.0810767583295103 4447 5412760
SGTC_1605 st000082 49.1 µM -1.4012935414051 0.096064213943932 no 3053 0.0805631558775847 4385 1114022
SGTC_2549 cedrol 20.94 µM -1.40317221701698 0.095757143412073 no 3054 0.0802827451448524 4382 6708665 A sedative which affects the nervous system.
SGTC_1986 st071812 45 µM -1.40635716335401 0.0952382130273658 no 3055 0.0798090468169734 4374 11838594
SGTC_221 trifluoperazine 10.304 µM -1.40868395410099 0.0948604148848775 no 3056 0.079464320829651 4426 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1975 st070967 30.8 µM -1.4201064504848 0.0930217655427032 no 3057 0.0777883463254418 4431 261391
SGTC_1411 3909-8223 150 µM -1.42286521330721 0.0925816705288088 no 3058 0.0773876161142748 4463 X1411
SGTC_887 0885-0007 9.62 µM -1.42447775822906 0.0923251416270149 no 3059 0.0771541095392798 4474 5719458
SGTC_2318 6029776 164 µM -1.4282004062197 0.0917349402799795 no 3060 0.0766170918715104 4477 818325
SGTC_2885 9057732 51.95 µM -1.42842056296421 0.0917001236184295 no 3061 0.0765854219995879 4474 6471414
SGTC_213 1246-0773 967 nM -1.43291319565892 0.090991773596897 no 3062 0.0759413228697793 4486 6251622
SGTC_2807 7945238 51.95 µM -1.4375846093648 0.0902595481646693 no 3063 0.0752759751771599 4434 17148797
SGTC_1729 st035615 45.989 µM -1.43810676484633 0.0901779750912642 no 3064 0.0752018817541668 4462 17385451
SGTC_970 1315-0089 19.5 µM -1.43953084286896 0.0899557786906389 no 3065 0.0750000889066826 4423 6811083 YLR033W RSC58
SGTC_1499 4480-0877 67.3 µM -1.43958629926069 0.0899471341646181 no 3066 0.0749922390599716 4447 2861909
SGTC_1348 1493-0373 93.8 µM -1.44019255620889 0.089852671270783 no 3067 0.0749064643159593 4490 3010129
SGTC_2884 9058502 51.95 µM -1.44196987292439 0.0895761666530304 no 3068 0.0746554364085773 4459 6471554
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.4420084771247 0.0895701678644812 no 3069 0.0746499910905422 4486 688788
SGTC_2991 9074669 71.4286 µM -1.44360146538429 0.0893228904720503 no 3070 0.0744255562486469 4415 17333109
SGTC_2425 5628681 7.85 µM -1.44850154963696 0.0885654411067112 no 3071 0.0737384164551291 4514 5714958
SGTC_277 nystatin 15.5 µM -1.44919714895747 0.0884583051496901 no 3072 0.073641266756266 4478 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.44956674072261 0.0884014200564303 no 3073 0.0735896881736306 4471 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2101 5377231 179.231 µM -1.44975926637512 0.0883717985952794 no 3074 0.0735628310939569 4490 2844213
SGTC_81 0411-0046 9.971 µM -1.45139864744742 0.0881198675591704 no 3075 0.0733344430818571 4458 12925265
SGTC_1356 1502-0781 85.8 µM -1.45254306680925 0.0879443171145541 no 3076 0.0731753316919989 4474 567702
SGTC_3053 9095903 49.47 µM -1.45530202848203 0.0875221732553319 no 3077 0.0727928326628022 4576 17174018
SGTC_2989 9073649 71.4286 µM -1.45861767318273 0.0870168552128828 no 3078 0.0723351832845927 4452 21367202
SGTC_2138 5575593 77.673 µM -1.45890477918188 0.0869732017956307 no 3079 0.0722956587821047 4477 762213
SGTC_483 fpl-64176 144 µM -1.46266350259589 0.0864032097620342 no 3080 0.0717797388194447 4607 3423
SGTC_3298 9116858 71.43 µM -1.46668644910674 0.0857962491420706 no 3081 0.0712306854094858 4531 2506942
SGTC_1597 7-benzyloxygramine 47.5 µM -1.46987717456597 0.0853171234344752 no 3082 0.0707975112754747 4379 260807
SGTC_2838 9002687 71.43 µM -1.47036193559184 0.0852445064938537 no 3083 0.070731877412648 4462 6457060
SGTC_2880 9042983 58.44 µM -1.47171853943009 0.0850415341088521 no 3084 0.0705484495366896 4425 6464714
SGTC_2817 7995342 71.43 µM -1.47185856831152 0.0850206039060192 no 3085 0.070529536917309 4456 18879975
SGTC_1182 1222-0449 220 µM -1.47340829328056 0.0847892233248922 no 3086 0.0703204876970573 4479 658318
SGTC_811 0416-0114 265 µM -1.47353282716318 0.0847706503980893 no 3087 0.070303709478176 4493 6612453
SGTC_2182 6325192 200 µM -1.47424325701467 0.084664755550058 no 3088 0.0702080534494795 4512 736248
SGTC_810 3825-7150 143 µM -1.47977591334131 0.0838434645321433 no 3089 0.069466529363362 4509 22330411 YGL099W LSG1
SGTC_104 0074-0074 590.992 µM -1.48098906049666 0.0836641823429028 no 3090 0.0693047443132753 4336 3943124
SGTC_988 1497-1057 103 µM -1.48190306941819 0.083529297972557 no 3091 0.0691830441162331 4472 3533044
SGTC_2354 9060492 162 µM -1.48459497224352 0.083132991279274 no 3092 0.0688255740625301 4503 6471895
SGTC_2912 7964298 10.93 µM -1.48594568434327 0.0829346705715584 no 3093 0.068646744211999 4484 2975850
SGTC_3187 9109394 49.47 µM -1.48697186632418 0.0827842376377595 no 3094 0.0685111207948012 4492 17098090
SGTC_1323 1348-1351 11.2 µM -1.48831487147785 0.0825876703818419 no 3095 0.0683339374229617 4473 6989654
SGTC_2229 7354935 190 µM -1.4887002810176 0.0825313253277589 no 3096 0.0682831554930674 4452 318112
SGTC_3104 9120930 49.47 µM -1.49183116370302 0.0820746769754949 no 3097 0.0678717060075137 4521 17014836
SGTC_1207 2099-0101 141 µM -1.49328263157664 0.0818636230624988 no 3098 0.0676816100131215 4488 5837381
SGTC_332 4112-0506 40.9 µM -1.50086403003662 0.0807678761381578 no 3099 0.0666953666768405 4481 2790355
SGTC_559 1550-0661 158 µM -1.50087564326276 0.0807662062043947 no 3100 0.0666938645215055 4531 5830875
SGTC_132 0417-1715 25.805 µM -1.5022815610306 0.0805642336269422 no 3101 0.066512204304076 4479 6769098
SGTC_1288 0973-0013 65.5 µM -1.50646682959226 0.0799652409204172 no 3102 0.0659736880488579 4525 4315430
SGTC_3281 9140613 49.47 µM -1.50850104332966 0.0796753245898184 no 3103 0.06571316992549 4479 16013766
SGTC_1501 4491-0275 38.4 µM -1.50934250124097 0.0795556326927751 no 3104 0.065605639370124 4501 5104718
SGTC_3333 9141820 12.094 µM -1.50981581672991 0.0794883664692193 no 3105 0.0655452140018139 4487 1939433
SGTC_731 3966-0296 387 µM -1.51003537259866 0.0794571784436377 no 3106 0.0655171992689333 4499 660956
SGTC_1179 1021-1431 9.29 µM -1.51524285015175 0.0787201655057372 no 3107 0.0648554576048829 4523 2840958
SGTC_2959 9079155 11 µM -1.51605512975005 0.0786056723501126 no 3108 0.0647527064404639 4515 16189457
SGTC_1433 4060-0023 7.6 µM -1.51679789776381 0.0785010875672334 no 3109 0.0646588589917731 4518 3840627
SGTC_611 3453-1652 23.7 µM -1.51771851368676 0.0783716075053849 no 3110 0.064542687414947 4511 1560575
SGTC_2222 6885208 172.143 µM -1.52019418645615 0.0780242196929584 no 3111 0.0642310890495964 4523 609514
SGTC_3327 9140648 26.9345 µM -1.52151745019105 0.0778390183169891 no 3112 0.064065017811264 4518 8029710
SGTC_3162 9099653 49.47 µM -1.5233707633834 0.077580193377815 no 3113 0.063832986144428 4486 25237511
SGTC_1454 4239-0054 42.6 µM -1.5247309447287 0.0773906530582335 no 3114 0.0636631100393219 4564 1340767
SGTC_2109 5483026 200 µM -1.52478219983466 0.0773835175777816 no 3115 0.0636567155574815 4515 759335
SGTC_1868 st057644 42.7 µM -1.52594778541988 0.0772213854203359 no 3116 0.0635114343466179 4530 688665
SGTC_2645 abamectin 100 µM -1.52852745124786 0.0768634735105576 no 3117 0.0631908165944589 4457 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_586 0957-0265 8.15 µM -1.53396248191559 0.0761135276442517 no 3118 0.06251944149913 4416 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2990 9074105 71.4286 µM -1.53779438198334 0.0755881446991877 no 3119 0.0620494488381097 4449 6502001
SGTC_815 1582-0027 36.9 µM -1.53841041435105 0.0755039403614263 no 3120 0.0619741487351672 4528 3128206
SGTC_721 1187-1332 279 µM -1.53917150889806 0.0754000064733629 no 3121 0.0618812155980685 4520 25730
SGTC_169 k015-0017 16.025 µM -1.54120180907034 0.0751232852758514 no 3122 0.0616338386795396 4495 1840002
SGTC_1658 st012944 20 µM -1.54547367967732 0.0745435774180438 no 3123 0.0611158652676771 4366 24207260
SGTC_511 blebbistatin 171 µM -1.54715828349826 0.074315911846402 no 3124 0.0609125412672582 4566 3476986 A myosin inhibitor.
SGTC_2490 carminic acid 95.39 µM -1.55167376193482 0.0737082871770856 no 3125 0.0603701519303742 4518 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1234 0326-0494 15.5 µM -1.55715067734858 0.072976392265747 no 3126 0.0597173577404857 4579 1547813
SGTC_2413 inermin 26.06 µM -1.55883817393983 0.0727520121950919 no 3127 0.0595173432685259 4551 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2657 nystatin 74.44 µM -1.56108996810515 0.0724534228455599 no 3128 0.0592512623673073 4549 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1149 3909-7961 23.3 µM -1.56678956945865 0.0717018480673251 no 3129 0.0585819431266558 4576 735261
SGTC_34 0469-0683 81.75 µM -1.56689813317598 0.07168759063735 no 3130 0.0585692520528371 4513 3690923
SGTC_1394 3474-0001 65.7 µM -1.56939448350201 0.0713603501629358 no 3131 0.0582780243345848 4510 5017666 YIL048W NEO1
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.57323753804422 0.0708588163910241 no 3132 0.0578319131779785 4569 1273210
SGTC_1708 st033234 31.827 µM -1.57802801276602 0.0702374374489782 no 3133 0.0572795872311811 4602 674664
SGTC_2897 9048598 12.99 µM -1.58729394089161 0.0690474442254832 no 3134 0.0562230434506165 4525 6467404
SGTC_3087 9117406 49.47 µM -1.58803729825481 0.068952654631591 no 3135 0.0561389526357285 4530 42546093
SGTC_1901 st060216 58.6 µM -1.59133944756107 0.0685327914096538 no 3136 0.0557666018287107 4509 688792
SGTC_1888 azatryptophan 97.5 µM -1.5923594282274 0.068403501882152 no 3137 0.0556519834495149 4546 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_568 1193-0097 7.48 µM -1.59411082592706 0.0681819393445593 no 3138 0.0554556072878702 4328 3646150
SGTC_428 3448-4153 16.5 µM -1.59586931235616 0.0679600377420821 no 3139 0.0552589871289956 4502 3834874
SGTC_2623 humulene 100 µM -1.60232853083076 0.0671497392771399 no 3140 0.0545414898871943 4527 6187145 An anti-inflammatory.
SGTC_704 1310-0270 142 µM -1.60283900880717 0.0670860205513773 no 3141 0.0544851010278499 4523 5718033
SGTC_385 1494-0393 12.4 µM -1.60340495253161 0.0670154331634767 no 3142 0.0544226391702671 4509 3090647
SGTC_1686 st019653 115.5 µM -1.60602035051153 0.0666899732985842 no 3143 0.0541347193254375 4539 97252
SGTC_2653 dihydrofissinolide 100 µM -1.60671945052103 0.0666031848764793 no 3144 0.054057962433671 4608 6857746
SGTC_2300 7976697 71.57 µM -1.61152369921545 0.0660091333368064 no 3145 0.0535328130177261 4444 2236109
SGTC_374 0880-0231 82.3 µM -1.6175845838213 0.0652655634743737 no 3146 0.0528760768076313 4415 6833587
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.61935876670419 0.0650491348065273 no 3147 0.0526850465856818 4570 6710655
SGTC_2277 7947813 106.88 µM -1.6220398280188 0.0647231354441422 no 3148 0.0523974102796617 4569 1246798
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.62328118820013 0.0645726246070178 no 3149 0.0522646545278662 4555 688798
SGTC_1646 st011709 75.6 µM -1.62906655541821 0.0638747514236548 no 3150 0.0516494651544292 4527 5757843
SGTC_2805 7950783 58.44 µM -1.62912538913772 0.0638676847218386 no 3151 0.0516432387453471 4557 1178958 YDL195W SEC31
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.63191696229483 0.0635330785395714 no 3152 0.0513484901055556 4502 4000243
SGTC_3015 9080845 49.47 µM -1.63196610467875 0.0635272004313169 no 3153 0.0513433134108684 4595 5296973
SGTC_3295 9122362 53.5725 µM -1.63274115711248 0.063434549414009 no 3154 0.0512617237128844 4544 4730473
SGTC_2493 resveratrol 26.09 µM -1.63577209157332 0.0630732361797337 no 3155 0.0509436475044923 4532 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.63657606492496 0.0629776651785424 no 3156 0.0508595400813545 4516 6708630 An antioxidant.
SGTC_1607 st000305 50.6 µM -1.63854500672667 0.0627440869013959 no 3157 0.0506540267293468 4566 5457690
SGTC_1085 doxorubicin 7.67 µM -1.641304474971 0.0624178641868608 no 3158 0.0503671138251466 4575 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_411 enrofloxacin 100 µM -1.64481023363157 0.0620053246698358 no 3159 0.0500044755575557 4597 71188 A bacterial gyrase inhibitor.
SGTC_1518 st038567 90.8 µM -1.64504871787939 0.061977338553594 no 3160 0.0499798824003471 4523 77966
SGTC_669 0108-0021 26.2 µM -1.64573984986177 0.0618962899191829 no 3161 0.049908665430284 4563 17201
SGTC_2767 sibutramine 71.45 µM -1.6462382630924 0.0618378926525117 no 3162 0.0498573572083575 4556 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2143 5623677 140.463 µM -1.64806994923646 0.061623650016048 no 3163 0.0496691590214274 4543 5375313
SGTC_844 0330-0132 15.3 µM -1.65342093730171 0.0610010922373695 no 3164 0.0491226123123585 4610 2828079
SGTC_2117 5521686 200 µM -1.65574051723189 0.0607327542580548 no 3165 0.0488871891587616 4566 803312
SGTC_2491 paeonol 100 µM -1.6607270133703 0.0601590231367005 no 3166 0.0483841427474533 4562 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3044 9093193 49.47 µM -1.66894769150455 0.059222450968087 no 3167 0.0475638734210245 4575 25236277
SGTC_1165 k072-0275 30.3 µM -1.67260982107205 0.0588089276779924 no 3168 0.0472020661216634 4575 6153523 YGL055W OLE1
SGTC_245 methotrexate 289.6 µM -1.67646216676951 0.0583763745664523 no 3169 0.046823850409972 4534 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1758 st042942 75.2445 µM -1.68251025963396 0.0577023218852763 no 3170 0.0462349685749302 4563 669317
SGTC_275 trichlorophene 5.69 µM -1.69012472427936 0.0568624192846289 no 3171 0.0455020478539285 4610 62616
SGTC_785 1270-0111 65.3 µM -1.69091258718717 0.0567760676782725 no 3172 0.0454267494489752 4505 6741994
SGTC_1600 coumarin 106 71.1 µM -1.69121233989593 0.0567432412213526 no 3173 0.0453981275198532 4630 100336 A hepatotoxic, DNA x-linker.
SGTC_804 1595-0054 20.9 µM -1.69202044840772 0.0566548182859225 no 3174 0.0453210374211178 4582 761523 Stimulates phospholipase C.
SGTC_1942 st076330 65.2 µM -1.69704618190704 0.0561073388915232 no 3175 0.0448439648831552 4607 24208414
SGTC_852 0418-0143 439 µM -1.69898546439979 0.0558972016152118 no 3176 0.0446609612092525 4566 5369229
SGTC_990 3985-0011 41.3 µM -1.69985728879918 0.0558029347692106 no 3177 0.0445788862435293 4556 5399565 YGL099W LSG1
SGTC_1209 2323-2347 50.3 µM -1.70193317135892 0.055578982894526 no 3178 0.0443839483160875 4605 5412760
SGTC_3220 9131269 49.47 µM -1.70523655252245 0.055224068545687 no 3179 0.0440751576909445 4593 17722206
SGTC_545 4218-0007 221 µM -1.70888171747618 0.0548345131489859 no 3180 0.0437364308581773 4598 2840508
SGTC_1623 st003709 20.3 µM -1.71367493688444 0.0543255758244382 no 3181 0.0432942211903146 4582 16192618
SGTC_735 3076-0345 636 µM -1.71619567848437 0.0540594304264981 no 3182 0.0430631169538584 4607 2888990
SGTC_1255 0566-0045 221 µM -1.72031375227221 0.0536268565832015 no 3183 0.0426877124886167 4596 2788469
SGTC_1007 4101-0031 70 µM -1.72101667492437 0.0535532943563171 no 3184 0.0426238990388897 4594 1146276
SGTC_2770 toltrazuril 17.5 µM -1.7248923162658 0.0531491354449692 no 3185 0.0422734402794553 4532 68591 Kills coccidiodes.
SGTC_1652 st011932 78 µM -1.72661306712493 0.0529704693651268 no 3186 0.0421185887853703 4541 1551076
SGTC_2394 5221648 200 µM -1.72697546757107 0.052932902009738 no 3187 0.0420860347263488 4613 788586
SGTC_70 0141-0289 43.283 µM -1.73297159556138 0.0523143903364769 no 3188 0.0415503587550405 4563 352408
SGTC_1879 gemcitabine 100 µM -1.73343133702697 0.0522672050216735 no 3189 0.0415095158908348 4579 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1798 st045719 60.953 µM -1.73475157202784 0.0521318912853717 no 3190 0.0413924086554323 4587 3980186
SGTC_2537 larixol 68.93 µM -1.7372218290551 0.051879456821465 no 3191 0.0411740116460707 4569 6708759
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.74112055537981 0.0514830251108832 no 3192 0.0408312244871706 4577 5282362
SGTC_171 k064-0041 9.68 µM -1.74193373276449 0.0514006437289833 no 3193 0.0407600202450405 4583 53325
SGTC_2581 avocatin a 64 µM -1.74262456599425 0.0513307391937271 no 3194 0.0406996080107743 4541 6710728 A skin care supplement.
SGTC_752 1896-0090 130 µM -1.74531263377219 0.0510594563946914 no 3195 0.040465231988351 4627 772567
SGTC_1309 pyrazolanthrone 13.4 µM -1.75023860522635 0.0505652843463504 no 3196 0.0400385749422086 4606 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3120 9124077 49.47 µM -1.75262328332258 0.0503274266102062 no 3197 0.0398333459882552 4698 18774327 YGL155W CDC43
SGTC_1554 st069299 38.7 µM -1.75270276722533 0.0503195139363679 no 3198 0.0398265202387864 4571 24207999
SGTC_1642 st009582 77.7 µM -1.75644321075669 0.0499482701985703 no 3199 0.0395063800575348 4603 6739311
SGTC_587 k089-0003 57 µM -1.75708160968493 0.0498851270679328 no 3200 0.0394519499315781 4546 9659696
SGTC_995 3931-2021 34.6 µM -1.75804644988473 0.0497898169364707 no 3201 0.0393698030913753 4603 730143
SGTC_1046 2001-0062 216 µM -1.75899477895559 0.0496962794432539 no 3202 0.039289197684288 4566 739778
SGTC_723 4182-0001 115 µM -1.7623273613614 0.0493686851049183 no 3203 0.0390070017827015 4604 744821 YLR208W SEC13
SGTC_2350 9023895 38.85 µM -1.76502758959603 0.0491045177788578 no 3204 0.0387795644888457 4578 2997209
SGTC_2094 5332512 191.667 µM -1.76728660425093 0.0488843834895322 no 3205 0.0385901210554025 4630 755774
SGTC_319 1348-1596 45.5 µM -1.77905204516812 0.0477505953747537 no 3206 0.0376156148527716 4669 5380505
SGTC_2254 7938975 95.19 µM -1.78086729039901 0.0475775576407709 no 3207 0.0374670666644574 4641 2969277
SGTC_109 0132-0036 33.701 µM -1.7924424166363 0.0464859439882998 no 3208 0.0365310627049509 4552 67274 A color developer.
SGTC_497 capsazepine 133 µM -1.80070749251293 0.0457188628871663 no 3209 0.0358744980229387 4580 2733484 A calcium channel blocker.
SGTC_2073 5212005 126 µM -1.81289635699443 0.0446062163279615 no 3210 0.0349239041166904 4584 691789
SGTC_3228 9131799 49.47 µM -1.82099385112722 0.0438791789916961 no 3211 0.0343038957795745 4664 17015818
SGTC_682 0kpi-0099 17 µM -1.82450118295825 0.0435672524525153 no 3212 0.0340381688324431 4634 1714895 YML126C ERG13
SGTC_2081 5214970 32.255 µM -1.82955638028385 0.043120816788973 no 3213 0.0336581506734912 4588 2063512
SGTC_2925 9010536 32.5 µM -1.8296063290691 0.0431164242072343 no 3214 0.0336544133276705 4574 2994177
SGTC_2447 5741742 33.78 µM -1.83154118571405 0.0429465475957086 no 3215 0.0335099031107603 4675 1776504
SGTC_1676 st018489 23.4 µM -1.83448851644642 0.0426888175196249 no 3216 0.0332907554391716 4594 3696235
SGTC_1853 st056710 91.2 µM -1.83598703588857 0.0425582594000309 no 3217 0.0331797870141132 4646 269167
SGTC_2019 4016004 108 µM -1.83752044844789 0.0424249956656231 no 3218 0.0330665502928152 4633 45595336
SGTC_627 1391-0720 175 µM -1.84677594913207 0.0416277821247801 no 3219 0.0323898094893279 4635 997839
SGTC_1797 st048695 56.8 µM -1.85114513851897 0.0412556855140204 no 3220 0.0320743379025419 4613 592262 YIL048W NEO1
SGTC_2218 6965428 192.983 µM -1.85406863508114 0.0410082185585339 no 3221 0.0318646706366326 4559 675684
SGTC_1810 st050138 53 µM -1.85753564074608 0.0407163067687567 no 3222 0.031617492696428 4661 3444541
SGTC_3032 9089427 49.47 µM -1.86123138747542 0.040406994784456 no 3223 0.0313557538483002 4622 17173707
SGTC_2654 protoveratrine a 100 µM -1.87508522082037 0.0392644524597525 no 3224 0.0303905002107311 4677 5702278 A heart drug and vasodilator.
SGTC_1490 4089-0339 670 nM -1.88134554023607 0.0387568517081156 no 3225 0.0299624649511865 4665 742542
SGTC_2614 arthonioic acid 13.39 µM -1.8828505708458 0.0386356208547565 no 3226 0.0298603107266036 4527 6710684
SGTC_3188 9110789 49.47 µM -1.88595793096205 0.038386299164833 no 3227 0.0296503119699131 4620 849217
SGTC_2720 fluspirilene 36.88 µM -1.89214321515897 0.037893921381146 no 3228 0.0292359508928452 4659 3396 An atypical antipsychotic.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.89408630442 0.0377403103717393 no 3229 0.0291067776443993 4670 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1587 estradiol valerate 56.1 µM -1.89637214232023 0.0375602544079581 no 3230 0.028955426430097 4689 13791 A steroid.
SGTC_892 0929-0076 29 µM -1.90582117221473 0.0368233805421382 no 3231 0.028336705519068 4662 5751038
SGTC_3223 9129970 49.47 µM -1.90718135947208 0.0367182875178534 no 3232 0.02824855323761 4660 17248386
SGTC_692 k241-0027 77.8 µM -1.90795595036704 0.0366585495121948 no 3233 0.0281984549184086 4679 3600480
SGTC_883 0850-0245 24.6 µM -1.92926748784442 0.0350459013483207 no 3234 0.0268488318708143 4685 6823229 YPR165W RHO1
SGTC_2649 anisomycin 9.56 µM -1.93076334588794 0.034934931118181 no 3235 0.0267561625719604 4699 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2223 6903751 107.57 µM -1.93102471357984 0.0349155711875491 no 3236 0.0267399981315263 4646 5598863
SGTC_2873 9040596 71.43 µM -1.93296630172112 0.0347720301368479 no 3237 0.0266201745961537 4633 6463863
SGTC_1741 st038134 10.228 µM -1.93912620452234 0.0343198343535149 no 3238 0.026242986292432 4661 1272587
SGTC_1325 1431-0015 227 µM -1.96033837079649 0.0327994945184585 no 3239 0.024978126995627 4662 1103340
SGTC_493 zm226600 134 µM -1.96726330122009 0.0323153523664054 no 3240 0.0245764317938417 4678 5240098 A potassium channel opener. YCR052W RSC6
SGTC_105 0111-0055 734.78 µM -1.97413321408967 0.0318408991292329 no 3241 0.0241832987736096 4686 5179370
SGTC_2450 5739737 12.93 µM -1.98210911696027 0.0312972969194486 no 3242 0.0237335146919676 4682 2262825
SGTC_736 0958-0254 92.6 µM -1.99455678856648 0.0304642708951541 no 3243 0.0230456202261209 4701 6812352
SGTC_379 3970-0972 5.9 µM -2.00383150719157 0.0298555990591397 no 3244 0.0225440562657692 4685 2898042 YBL034C STU1
SGTC_650 1328-0195 38 µM -2.00677312829448 0.0296646694663003 no 3245 0.0223869126767302 4683 2780821
SGTC_1211 1056-0033 32.3 µM -2.00697626838415 0.029651521892332 no 3246 0.022376094970229 4694 6741922
SGTC_2126 5251174 33.877 µM -2.01431762788725 0.0291796119758999 no 3247 0.0219880981875821 4657 790722
SGTC_3074 9116018 49.47 µM -2.01451338184877 0.0291671146125307 no 3248 0.0219778306715237 4701 17027303
SGTC_989 1501-0895 10.3 µM -2.02646318530726 0.0284125908671838 no 3249 0.0213586708300872 4686 2830112
SGTC_543 3844-1095 191 µM -2.03832317597443 0.0276798673116997 no 3250 0.0207588117987571 4697 4230703
SGTC_2251 lansoprazole 556 µM -2.04214515398979 0.0274471229681708 no 3251 0.0205685674978763 4683 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_172 1112-0046 2.638 µM -2.05513408677269 0.0266683082433014 no 3252 0.0199330276815511 4686 2802135 YIL048W NEO1
SGTC_1112 tnp00069 1.16933 µM -2.05749716350966 0.0265286219295841 no 3253 0.0198192137433595 4686 145826
SGTC_3274 9138298 49.47 µM -2.06919996743202 0.0258458250404915 no 3254 0.0192636628916258 4673 17015756
SGTC_362 0310-0100 9.03 µM -2.06958014267335 0.0258238927690151 no 3255 0.019245839598678 4698 790235
SGTC_1008 4106-0037 6 µM -2.07331478495091 0.0256092684408983 no 3256 0.0190714968121331 4720 2905394
SGTC_1464 k208-0027 110 µM -2.07605235749941 0.0254528945182146 no 3257 0.0189445544154981 4694 X1464
SGTC_724 3910-0327 137 µM -2.07850191436096 0.02531365113688 no 3258 0.0188315773813735 4703 2885483
SGTC_1507 4075-3230 155 µM -2.07939884745015 0.0252628254670028 no 3259 0.0187903531798171 4664 659771
SGTC_311 1315-0136 58 µM -2.08139807856924 0.0251498445489035 no 3260 0.0186987422043725 4716 6759207
SGTC_1963 st076565 50.3 µM -2.08389590812552 0.0250092820923921 no 3261 0.0185848183203658 4727 4914280
SGTC_65 0798-0905 34.986 µM -2.08862520535471 0.0247449501678491 no 3262 0.0183707372174391 4650 3602145
SGTC_2464 5717415 7.67 µM -2.09312168056778 0.0244958085878607 no 3263 0.0181691468987125 4669 5285744
SGTC_2762 leflunomide 42.06 µM -2.09383594497258 0.0244564269316581 no 3264 0.0181372984722051 4666 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_28 pentachloropyridine N-oxide 1.606 µM -2.09418199493105 0.0244373662536567 no 3265 0.0181218855254617 4711 140250 A respiratory chain inhibitor.
SGTC_2160 5660466 132.927 µM -2.10462614571788 0.0238679358313754 no 3266 0.0176619319341753 4689 2859134
SGTC_2147 5545932 89.7195 µM -2.10697486326851 0.0237414280121071 no 3267 0.0175598792584275 4735 797404
SGTC_1293 1000-1278 195 µM -2.10950691199194 0.0236056775024568 no 3268 0.0174504250150754 4713 678847
SGTC_2215 7188065 200 µM -2.12156406140487 0.0229681821601246 no 3269 0.0169371815126843 4737 940217
SGTC_1134 3477-0009 42.5 µM -2.12288511582359 0.022899224100703 no 3270 0.0168817400011914 4688 3973534
SGTC_48 0382-0018 55 µM -2.14237183997755 0.0219021270894466 no 3271 0.0160817860288758 4704 762596
SGTC_1899 st063254 59.6 µM -2.14424467026994 0.0218082590434302 no 3272 0.0160066437818117 4709 3093813
SGTC_2821 7996764 71.43 µM -2.15471299041173 0.0212898125400267 no 3273 0.0155921503111853 4674 2987135
SGTC_1321 1326-2144 215 µM -2.15530328271173 0.0212608912412255 no 3274 0.0155690545448935 4709 3513030
SGTC_1748 st037455 53.6035 µM -2.15726742981561 0.0211648972054904 no 3275 0.0154924166112935 4699 580690
SGTC_1795 st049545 62.3 µM -2.15930711223621 0.0210655998382226 no 3276 0.0154131743683334 4704 5291882
SGTC_696 1560-0013 611 µM -2.1743535693739 0.0203452068666479 no 3277 0.0148392961007195 4721 1650269
SGTC_1276 0871-0068 94.2 µM -2.18454282214419 0.0198693161969624 no 3278 0.0144611921107755 4724 3414906
SGTC_2591 skatole 100 µM -2.19068188530896 0.0195871760971265 no 3279 0.0142374104300641 4685 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_99 0109-0120 622.8 µM -2.19314322810991 0.0194750165925873 no 3280 0.0141485306711304 4721 759414
SGTC_513 4245-1575 41.7 µM -2.20070245356232 0.0191339593903387 no 3281 0.0138785475065944 4569 719745
SGTC_2874 9043904 71.43 µM -2.20741080653027 0.0188355576253708 no 3282 0.0136426860399624 4671 4463428
SGTC_532 1548-0774 215 µM -2.21289261782766 0.0185946634627725 no 3283 0.013452524886362 4744 5932993
SGTC_3107 9121808 49.47 µM -2.2338337937962 0.0176984217315083 no 3284 0.0127470055444007 4687 662681
SGTC_1 0258-0098 57.368 µM -2.23913308934491 0.0174775560896885 no 3285 0.0125736289226599 4651 6790032 YDR047W HEM12
SGTC_595 3909-8003 73.7 µM -2.241362828685 0.0173853301612182 no 3286 0.0125012911229486 4764 699517
SGTC_1224 0823-0416 294 µM -2.24753732227115 0.0171321084099911 no 3287 0.0123028540657529 4742 3598164
SGTC_1555 citronellol 128 µM -2.24790502834606 0.0171171283962388 no 3288 0.0122911232388109 4739 8842 A terpine precursor.
SGTC_3300 9124615 50.48 µM -2.24857220836364 0.0170899766648635 no 3289 0.0122698631191706 4709 24824903
SGTC_2119 5528445 120.635 µM -2.25959715731027 0.0166466045585389 no 3290 0.0119231320975795 4735 791935
SGTC_1166 k206-0078 225 µM -2.26601683083941 0.0163929975439705 no 3291 0.0117251763835709 4731 5404595
SGTC_38 0929-0051 58.268 µM -2.26689554540688 0.0163585429605696 no 3292 0.0116983037106329 4704 1379719
SGTC_601 0986-0029 62.9 µM -2.26810833457498 0.0163110911135846 no 3293 0.011661302254004 4704 24747981
SGTC_35 0133-0054 64.071 µM -2.26924266703084 0.016266815723388 no 3294 0.0116267864592777 4684 99677
SGTC_2492 derrusnin 100 µM -2.2728773268635 0.0161256400087557 no 3295 0.0115167867409636 4755 1715307 Part of coumarin class of compounds.
SGTC_1678 st019265 80.2 µM -2.28493242193942 0.0156648929348222 no 3296 0.0111583952917431 4717 5367020
SGTC_1711 st032263 62.8 µM -2.29331953820388 0.015351039488526 no 3297 0.0109148075904099 4737 3958979
SGTC_2106 5357045 167.29 µM -2.29626058367204 0.0152422690691221 no 3298 0.0108304931885525 4744 668842
SGTC_2973 9094665 17.96 µM -2.29982541898091 0.0151113167537664 no 3299 0.0107290563777719 4703 25237061 YIL048W NEO1
SGTC_2276 7947513 42.08 µM -2.30187992839163 0.0150362854775568 no 3300 0.0106709722128612 4682 2105100
SGTC_1060 3448-7350 82 µM -2.30471412910328 0.0149333053089184 no 3301 0.0105912945288378 4717 570178
SGTC_963 1269-2853 151 µM -2.32479880343995 0.0142207588435479 no 3302 0.0100413605136187 4733 3668223
SGTC_2225 6654152 15.4 µM -2.3522983612954 0.0132927795603385 no 3303 0.00932890125050851 4742 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2395 5646831 180.19 µM -2.35428051267948 0.0132279600307539 no 3304 0.00927930006603315 4715 6808628
SGTC_2719 novobiocin 32.65 µM -2.3567300760516 0.0131482327918551 no 3305 0.00921832133814152 4751 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1322 1348-1070 12 µM -2.37682577065162 0.0125097012778757 no 3306 0.00873116704511501 4742 6758089
SGTC_2937 9044753 11.33 µM -2.39065395422974 0.0120860702726817 no 3307 0.00840919813697852 4705 6465530 YGL099W LSG1
SGTC_2814 7977482 42.97 µM -2.39089975082563 0.0120786541139356 no 3308 0.00840357067325593 4730 6456762
SGTC_2533 agelasine 13.65 µM -2.39748488407458 0.0118814313687366 no 3309 0.00825403104349702 4743 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_975 1335-0046 28.5 µM -2.39938837156047 0.0118249455182813 no 3310 0.00821124311334663 4751 16486740
SGTC_837 0091-0265 12.5 µM -2.44097945848807 0.0106476047593561 no 3311 0.00732374395118305 4759 759367
SGTC_1813 st051246 8.6015 µM -2.476678071141 0.00971984529408266 no 3312 0.00663057274168394 4753 5291959
SGTC_1922 5578187 25 µM -2.48853236294568 0.00942779320354976 no 3313 0.00641357810763773 4739 1350412
SGTC_2987 9018338 71.43 µM -2.49951237225903 0.00916415689940188 no 3314 0.00621821782299442 4759 5055682
SGTC_1996 st072960 66.8 µM -2.50398199278005 0.00905870096236109 no 3315 0.0061402142096226 4784 1719405
SGTC_357 1325-0123 420 µM -2.51307787841548 0.00884737047305874 no 3316 0.00598414556257607 4755 1098503
SGTC_2867 9039098 71.43 µM -2.55750186546004 0.0078761496825394 no 3317 0.00527134962599846 4752 6463460
SGTC_2271 7849410 118.62 µM -2.61841298736261 0.00669738935506073 no 3318 0.0044169909015743 4733 972430
SGTC_1289 0976-0073 69.1 µM -2.62370288495843 0.00660278411148075 no 3319 0.00434898121632768 4786 3391136
SGTC_3 0833-0587 95.581 µM -2.65384508946265 0.00608593282840669 no 3320 0.00397901757961971 4697 5382644
SGTC_1816 st051957 91.6 µM -2.67215472939029 0.00578977758457117 no 3321 0.00376829441269725 4784 674121
SGTC_2546 rhodinyl acetate 100 µM -2.67468131237125 0.00574993101709433 no 3322 0.00374001584441925 4768 6708682
SGTC_1279 0874-0590 65.2 µM -2.71228724621287 0.00518496366073254 no 3323 0.00334103303528995 4796 3523074
SGTC_2875 9039966 71.43 µM -2.71335539451012 0.00516966445591272 no 3324 0.00333028155038207 4779 6463691
SGTC_763 3453-1109 128 µM -2.72767342910586 0.00496842997170944 no 3325 0.00318913594866091 4778 1560353
SGTC_1508 1080-0625 72.9 µM -2.73013089082803 0.00493460176903282 no 3326 0.00316545919128099 4750 767111
SGTC_1896 st058441 89 µM -2.78229898627858 0.00426327966841481 no 3327 0.0026987644971842 4787 688759
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.78345479159213 0.00424937902148197 no 3328 0.00268916786163053 4734 4330530
SGTC_2872 9044037 25.97 µM -2.81363915163763 0.00390041556577412 no 3329 0.00244920902181772 4798 6465195
SGTC_705 1124-0212 310 µM -2.84521588133132 0.00356304486332709 no 3330 0.00221906663787218 4779 9554485
SGTC_1819 st053448 58.6 µM -2.89333056919377 0.00309919325252472 no 3331 0.00190589941790466 4787 2857616
SGTC_50 0929-0078 56.389 µM -2.90851567493472 0.00296452216665722 no 3332 0.00181574485426274 4738 1377751
SGTC_2079 5212404 121 µM -2.95321393822012 0.00259817236972115 no 3333 0.00157241965093943 4772 758462
SGTC_2597 laccaic acid a 100 µM -2.9683657620243 0.00248359871969031 no 3334 0.0014969392016072 4772 5491415 A textile dye.
SGTC_2462 5162487 171.77 µM -2.97755926969938 0.00241632725064924 no 3335 0.0014527673017361 4785 2259986
SGTC_2291 7917025 104.35 µM -3.0186956397616 0.00213506608984258 no 3336 0.00126932715546895 4759 2964612
SGTC_1274 0865-0114 173 µM -3.06553981122622 0.00185117062913698 no 3337 0.00108638724601828 4794 870624
SGTC_1057 3448-5381 134 µM -3.07299551494595 0.0018092937566407 no 3338 0.0010596083639563 4783 5497911
SGTC_1673 st016611 27.3 µM -3.13325423954421 0.00150118943219397 no 3339 0.000864398127019843 4784 5226799
SGTC_52 0329-0193 875 nM -3.14797214916763 0.00143360204484526 no 3340 0.000822036784297502 4788 3739292
SGTC_2162 5663267 200 µM -3.16624896897925 0.0013535419756603 no 3341 0.000772092823608651 4801 6456493
SGTC_3346 9158254 43.5805 µM -3.19171504079642 0.00124879350618825 no 3342 0.000707153942400391 4795 17639500
SGTC_37 0566-0070 1.56 µM -3.19285547624694 0.00124428091224948 no 3343 0.000704367167934648 4787 1626686
SGTC_1056 3448-1962 115 µM -3.19503948748102 0.00123568060661783 no 3344 0.000699058550040825 4791 715507
SGTC_1682 st012968 530 nM -3.22651012589052 0.00111764602880549 no 3345 0.000626548989791827 4784 24207270
SGTC_2514 salinomycin 42.74 µM -3.30911312931371 0.000855266487401836 yes 3346 0.000467960058232861 4793 23682228 A polyether potassium ionophore.
SGTC_2448 5185112 27.17 µM -3.32386358746506 0.000814859618546762 yes 3347 0.000443898053740432 4793 5718189
SGTC_481 bay k-8644 50 µM -3.34116068398318 0.000769717980604017 yes 3348 0.000417144620553171 4800 2303 A calcium channel antagonist.
SGTC_3285 9112818 20.8695 µM -3.8276546409379 0.000139357096855817 yes 3349 6.46850522386079e-05 4801 17017947 YPR165W RHO1
SGTC_181 1447-1644 8.07 µM -3.86656930734518 0.000120475961453141 yes 3350 5.51885529744685e-05 4790 534600
SGTC_760 0568-0725 82.9 µM -3.90064428864704 0.000105940903820681 yes 3351 4.79685132306726e-05 4804 3916171
SGTC_53 0973-0023 39.979 µM -4.17170193856264 3.67432381854799e-05 yes 3352 1.51166475149614e-05 4802 674768
SGTC_757 1066-0008 322 µM -4.42805469351543 1.27189416835036e-05 yes 3353 4.7543396385866e-06 4810 6842497