SGTCid condition conc unit PRS3|YHL011C.score PRS3|YHL011C.strain.pval PRS3|YHL011C.strain.significant PRS3|YHL011C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1877 wortmannin 25 µM 9.4684884855349 8.34854983500622e-19 yes 1 1.41961114789674e-21 18 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1304 1165-0502 251 µM 8.64670973519869 5.49855638983494e-16 yes 2 2.65027857005862e-18 16 767425
SGTC_1874 staurosporine 7.6 µM 8.08324587964908 3.38096960869298e-14 yes 3 3.15326453915154e-16 6 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1154 4088-0362 150 µM 7.85981142100517 1.60700946559543e-13 yes 4 1.92356101435503e-15 1 6618304
SGTC_221 trifluoperazine 10.304 µM 7.56672414621035 1.16471996305193e-12 yes 5 1.91376740991042e-14 91 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2322 7413319 38.22 µM 7.42495412079903 2.95798895416305e-12 yes 6 5.6409507093815e-14 41 1840400
SGTC_974 1326-0144 138 µM 7.35232994066321 4.73689557977849e-12 yes 7 9.7390636552947e-14 5 5411856
SGTC_2132 5317594 122.667 µM 7.35096640360174 4.77875538500916e-12 yes 8 9.83894406414248e-14 7 794577
SGTC_2651 TUB2.036 5 µM 7.13096315728376 1.93595940312553e-11 yes 9 4.98344989497637e-13 45 15992207 YFL037W TUB2
SGTC_337 1315-0038 354 µM 7.0996126024901 2.35522978298087e-11 yes 10 6.25535388770023e-13 3 1626437
SGTC_1781 st038725 66.3 µM 7.04802761768816 3.24591061151782e-11 yes 11 9.0735813956448e-13 38 4270275 YIL048W NEO1
SGTC_2430 5571206 200 µM 7.03184260596936 3.58792008025539e-11 yes 12 1.01911827989211e-12 15 1731771
SGTC_3063 1327-0034 4 µM 6.03171484549599 1.141698768617e-08 yes 13 8.11144288716207e-10 22 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2932 9016711 44.54 µM 5.77970597922065 4.27259063374898e-08 yes 14 3.74156430969462e-09 13 7117328
SGTC_2976 9009005 19.48 µM 5.74414999903041 5.12506156495109e-08 yes 15 4.61919341025322e-09 13 2993148
SGTC_3059 1327-0034 3 µM 5.53619276037818 1.45416028767863e-07 yes 16 1.54558676178098e-08 29 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3303 9125618 40.5795 µM 5.46855091511423 2.02559982320402e-07 yes 17 2.26864867381285e-08 17 22695467
SGTC_2239 6685329 187.64 µM 5.35994733371647 3.42135765076499e-07 yes 18 4.16231084600167e-08 6 805680
SGTC_1562 morin hydrate 59.1 µM 5.20304918521683 7.17044971176977e-07 yes 19 9.80224780179443e-08 2 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_445 e6 berbamine 66 µM 5.062525719001 1.36714814021026e-06 yes 20 2.06869114360654e-07 60 6610268 A calcium/calmodulin antagonist.
SGTC_161 4065-0411 162.148 µM 5.05829259288991 1.39363152294993e-06 yes 21 2.11513507606291e-07 38 1906281 YLR208W SEC13
SGTC_1907 st060210 83.7 µM 5.04700408363135 1.46668360203868e-06 yes 22 2.24395881015534e-07 7 688793
SGTC_2233 sulbentine 40.3845 µM 5.01522852688179 1.69257310802393e-06 yes 23 2.64852338844513e-07 34 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2150 5556613 200 µM 4.95895227497528 2.17688031006065e-06 yes 24 3.54371870901989e-07 4 743190
SGTC_108 0509-0257 621.132 µM 4.90220439803696 2.79823193053153e-06 yes 25 4.73835773308048e-07 25 536624
SGTC_682 0kpi-0099 17 µM 4.88501427692157 3.01778613795397e-06 yes 26 5.17106798026802e-07 40 1714895 YML126C ERG13
SGTC_1256 0570-0116 285 µM 4.86232242660043 3.33295755070675e-06 yes 27 5.80082210005203e-07 5 410638
SGTC_2077 5212015 200 µM 4.66856111852365 7.6502476898338e-06 yes 28 1.51658274090074e-06 41 780900
SGTC_163 TUB2.036 7.546 µM 4.65183756003595 8.20708332384585e-06 yes 29 1.64495096787506e-06 78 15992207 YJR013W GPI14
SGTC_375 3970-0961 9.27 µM 4.47382603481903 1.70914435454179e-05 yes 30 3.84161297707891e-06 11 2898222
SGTC_2345 9052315 157.45 µM 4.42071958610393 2.11655684790513e-05 yes 31 4.91863814598257e-06 15 6469265
SGTC_2137 5261020 140 µM 4.39189907759059 2.37464187165342e-05 yes 32 5.61824289816667e-06 32 763655
SGTC_845 0330-0138 4.51 µM 4.3659247598918 2.63255664925009e-05 yes 33 6.32930256259336e-06 11 9039800
SGTC_2688 kanamycin b 96.69 µM 4.35560151748614 2.74225677118592e-05 yes 34 6.63509982574256e-06 315 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2041 5107442 45.335 µM 4.3530046652794 2.77052634766271e-05 yes 35 6.71421458025581e-06 18 793005
SGTC_2469 5655019 90.81 µM 4.28792508268047 3.57604469903469e-05 yes 36 9.01749477185796e-06 18 2788239
SGTC_1199 1638-0010 4.46 µM 4.26941925657324 3.84278142132245e-05 yes 37 9.79912893489325e-06 18 3111136
SGTC_1694 st024011 44.9 µM 4.25636020701315 4.04221520599246e-05 yes 38 1.03890926035403e-05 31 2787533
SGTC_3093 9117344 49.47 µM 4.21852372529855 4.67672780754807e-05 yes 39 1.22953549539556e-05 11 24824913
SGTC_1803 st050068 52.4 µM 4.21443474669214 4.7506699365193e-05 yes 40 1.25202267286024e-05 163 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 4.1328756307751 6.47740412667955e-05 yes 41 1.79126300914882e-05 31 5379071
SGTC_3237 9133362 49.47 µM 4.1292200607208 6.56720593340069e-05 yes 42 1.81997944888156e-05 31 43845137
SGTC_2064 5220758 200 µM 4.09859467624063 7.36698974641464e-05 yes 43 2.07833104800087e-05 32 788518
SGTC_1800 st050079 29.0735 µM 4.00974393745129 0.000102377536521178 yes 44 3.03923143945333e-05 115 3645560
SGTC_1545 lovastatin 49.4 µM 4.00854238492755 0.00010282960502969 yes 45 3.05473373147596e-05 21 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1173 0443-0020 122 µM 4.00303255846978 0.000104926722742463 yes 46 3.12678460575651e-05 32 5331295
SGTC_232 clozapine 119 µM 3.99798727267854 0.000106882198802039 yes 47 3.19416926293132e-05 64 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_440 fluspirilene 35.1 µM 3.95812400124044 0.000123580341309525 yes 48 3.77703700387725e-05 12 3396 An atypical antipsychotic.
SGTC_59 0330-0160 1.33 µM 3.8947378329918 0.000155251933357189 yes 49 4.91524978001324e-05 117 4293482
SGTC_1240 0356-0016 42.1 µM 3.87704090492893 0.000165366616666814 yes 50 5.28672935865147e-05 38 4305613
SGTC_18 0111-0177 500 nM 3.87441492008711 0.000166919012840626 yes 51 5.3440587561806e-05 76 721752
SGTC_823 0417-1665 178 µM 3.82150911915644 0.000201253291815719 yes 52 6.63187541691019e-05 43 3429856
SGTC_2806 7952793 58.44 µM 3.81990126483518 0.000202393421278087 yes 53 6.67525525984972e-05 24 2972490
SGTC_831 k061-1017 217 µM 3.80970839930984 0.000209762717687127 yes 54 6.9565394928836e-05 70 1240153
SGTC_1018 4259-0013 28.1 µM 3.77662599744867 0.000235443573288659 yes 55 7.94835798983823e-05 27 6801262
SGTC_581 0958-0271 211 µM 3.70821362074225 0.000298117924370976 yes 56 0.000104363270585593 58 4591145
SGTC_830 4076-0286 57.8 µM 3.70549294447196 0.0003009056643262 yes 57 0.000105490001590427 74 6866659
SGTC_1237 0330-0133 46.1 µM 3.67791763703942 0.000330562587524607 yes 58 0.000117572929656961 33 X1237 YHR072W ERG7
SGTC_3060 1327-0027 12.5 µM 3.64525516345907 0.000369200486979846 yes 59 0.000133563313200508 44 16000455 YPR107C YTH1
SGTC_1242 0402-0103 60.1 µM 3.6107910670928 0.000414488460708297 yes 60 0.000152632252611665 32 432868
SGTC_888 0916-0002 6.97 µM 3.60929569324763 0.000416565523254734 yes 61 0.000153514738485534 55 2802138 YIL048W NEO1
SGTC_592 k241-0073 46.5 µM 3.58955452014996 0.000444906332159363 yes 62 0.000165621774650573 27 4230158
SGTC_90 0870-0863 4.608 µM 3.57353490592325 0.000469207025536464 yes 63 0.000176097134358454 60 1738164
SGTC_129 0088-0017 176.636 µM 3.55946602528875 0.000491556852996903 yes 64 0.000185804800772014 78 182446
SGTC_34 0469-0683 81.75 µM 3.44933914448851 0.000703671022614718 yes 65 0.000280980213476488 43 3690923
SGTC_2618 avocadyne 43.43 µM 3.44649133264121 0.000710137026132219 yes 66 0.000283958391182493 49 3015189
SGTC_1656 st012921 11 µM 3.43655328925413 0.000733133045568768 yes 67 0.000294583220189449 46 6732821
SGTC_2290 7904846 200 µM 3.41343386437316 0.000789309834031797 yes 68 0.000320748631972664 44 2962154
SGTC_528 3492-0019 172 µM 3.37157853658617 0.000901202846956175 yes 69 0.000373693629901922 269 2869262
SGTC_3124 9127567 49.47 µM 3.37096523906854 0.000902945723942018 yes 70 0.000374526543574512 33 17592030
SGTC_55 0767-0285 6.563 µM 3.36580582956711 0.000917730914846723 yes 71 0.000381602055531483 66 3116166
SGTC_1309 pyrazolanthrone 13.4 µM 3.35910990789234 0.000937250943071093 yes 72 0.000390969807741399 38 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_134 0269-0018 6.916 µM 3.35861794743796 0.000938700045636757 yes 73 0.000391666421941896 170 4378915
SGTC_2499 avocadenofuran 51.48 µM 3.33712392935418 0.0010040579030252 no 74 0.000423250969401072 64 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1557 sumaresinolic acid 42.3 µM 3.33423761058096 0.00101314567894214 no 75 0.000427667785384127 38 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1232 0279-0259 161 µM 3.33028099156181 0.00102572603928312 no 76 0.000433791918346033 45 1560000
SGTC_2947 9072639 7.68 µM 3.32901267532585 0.00102978897701129 no 77 0.000435772189192457 75 16488146
SGTC_1772 st048439 82.2 µM 3.31713471596154 0.00106856183040331 no 78 0.000454728765714045 58 2927068 YDL195W SEC31
SGTC_1313 1220-0047 237 µM 3.3166513540685 0.00107016763628501 no 79 0.00045551613138086 65 3528706
SGTC_1071 trifluoperazine 6.31 µM 3.29432380945847 0.00114679994953751 no 80 0.000493293867602162 47 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1801 st050089 28.441 µM 3.29395607097964 0.00114810314907994 no 81 0.000493939680518466 169 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_639 0833-0042 114 µM 3.28729266611881 0.00117195327484631 no 82 0.000505778230510695 78 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1487 3970-0795 2.82 µM 3.28096478784474 0.00119502160326291 no 83 0.000517263293475818 32 3765103
SGTC_2510 benzyl isothiocyanate 8.31 µM 3.25895489514845 0.00127853376272002 no 84 0.000559117224129683 35 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2124 5246320 200 µM 3.25333003553442 0.00130071579458325 no 85 0.000570304684234706 44 579342
SGTC_2167 5876490 200 µM 3.24040730011447 0.00135301643160083 no 86 0.000596795371926152 65 686534
SGTC_638 3970-0837 4.09 µM 3.2378531061693 0.00136357842399075 no 87 0.000602164007440416 73 4118451 YLR208W SEC13
SGTC_2967 9089538 49.85 µM 3.22639024602209 0.00141191298739518 no 88 0.000626811506963318 63 728216
SGTC_1699 st031318 29.054 µM 3.22303045335449 0.00142637357247529 no 89 0.000634210337948145 40 5340658
SGTC_1101 ebselen 5.29 µM 3.21646847286307 0.00145500703061841 no 90 0.000648893959758373 50 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2255 7941087 197.44 µM 3.20693407713426 0.00149754629059053 no 91 0.00067078867623547 59 935561
SGTC_3166 9102297 49.47 µM 3.20662202015308 0.00149895756671652 no 92 0.000671516668090472 58 25237072
SGTC_3235 9132602 49.47 µM 3.20542402017231 0.00150438679282352 no 93 0.000674318235308636 61 4912240
SGTC_1150 3909-7983 10.9 µM 3.19415747438565 0.00155633032837082 no 94 0.000701197978977163 56 23965914
SGTC_679 0422-0091 41.4 µM 3.19303327461518 0.00156160208004303 no 95 0.000703933612349927 67 627384 YHR062C RPP1
SGTC_2775 cyproheptadine 69.59 µM 3.18142815670549 0.00161698168261325 no 96 0.000732754330854446 33 2913 A selective serotonin reuptake inhibitor.
SGTC_2706 st078239 82.5 µM 3.1734836506501 0.00165591840146912 no 97 0.000753106923051741 40 15434492
SGTC_2112 5488546 200 µM 3.17097285186572 0.00166840048666064 no 98 0.00075964670635355 45 600757
SGTC_1726 st035556 14.5795 µM 3.15079546513973 0.00177186314394237 no 99 0.000814132360348243 79 5919439
SGTC_1521 st012942 49.4 µM 3.13824755009512 0.00183911413091197 no 100 0.00084980634913104 81 24207259
SGTC_1891 st059073 26.2 µM 3.13811798150289 0.00183982050415679 no 101 0.000850182101986071 52 688754
SGTC_1687 st020778 55.3625 µM 3.13803833708684 0.0018402548265792 no 102 0.000850413149045206 225 4259299
SGTC_439 amiodarone 34.4 µM 3.12600592301942 0.00190695187980298 no 103 0.000885989914072802 141 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_543 3844-1095 191 µM 3.12418712940644 0.00191722260449664 no 104 0.000891485126450013 86 4230703
SGTC_470 aa-861 153 µM 3.11852293251953 0.00194953112296793 no 105 0.000908799983732325 96 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2508 celastrol 40.54 µM 3.10088987490821 0.00205330108358522 no 106 0.00096470015933494 43 122724 Celastrol is a natural product and antioxidant.
SGTC_7 0192-1582 4.227 µM 3.09308663210347 0.00210080277977585 no 107 0.000990431502136021 122 252616
SGTC_1275 0867-0008 21.1 µM 3.08009071758219 0.00218213133794488 no 108 0.00103468776822365 42 3422836
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 3.07942203815205 0.00218639213375847 no 109 0.00103701322554949 81 6728940
SGTC_1499 4480-0877 67.3 µM 3.06376553323354 0.0022883349173227 no 110 0.00109285069724884 30 2861909
SGTC_364 0083-0097 67.7 µM 3.0177565358971 0.00261330529506228 no 111 0.0012732670087767 70 5207356
SGTC_486 niguldipine 82 µM 2.99388462760432 0.00279785352404428 no 112 0.0013772504030896 42 1236 A calcium channel blocker.
SGTC_1444 4112-3581 28 µM 2.98654418571493 0.00285691942946752 no 113 0.00141075030529508 48 2877249
SGTC_3201 9113999 49.47 µM 2.95951742887069 0.00308421028410443 no 114 0.00154060636230302 84 16649224
SGTC_1824 st053723 68.6 µM 2.95385710238075 0.00313382675273087 no 115 0.001569146426517 79 675225
SGTC_8 0354-0001 70 µM 2.94852006978459 0.00318126626468697 no 116 0.00159649703195324 146 4993152
SGTC_1032 k061-1018 98.7 µM 2.94667762313803 0.00319779274872929 no 117 0.00160603941014719 72 4005393
SGTC_1712 st032288 53.4 µM 2.9464070250787 0.00320022647010143 no 118 0.00160744525747363 275 2883011
SGTC_871 0574-0004 149 µM 2.94196141718302 0.00324044896526486 no 119 0.0016307027959595 105 9551173
SGTC_176 1486-1328 72.834 µM 2.92678790689626 0.00338118181841801 no 120 0.00171241174960076 126 22310231
SGTC_1617 st002906 78 µM 2.91685123980705 0.00347629575785617 no 121 0.00176792182844834 80 5150859
SGTC_1738 st035555 74 µM 2.91496147874493 0.00349465422313937 no 122 0.00177866223898145 89 5331140
SGTC_2088 5278280 127.392 µM 2.90239166218452 0.00361899795985982 no 123 0.00185162612396903 84 791502
SGTC_836 0330-0104 1.35 µM 2.89670447968395 0.00367655045836635 no 124 0.00188552399392467 59 46494820
SGTC_451 chloral hydrate 100 µM 2.89255167129666 0.00371909284689103 no 125 0.0019106316048813 123 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2327 6189656 200 µM 2.85094129216576 0.00417036703701387 no 126 0.0021795008441838 63 5349088
SGTC_2657 nystatin 74.44 µM 2.84793336670135 0.00420481285961101 no 127 0.00220020684409621 58 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2496 diffractaic acid 79.83 µM 2.83204222478603 0.00439105118306812 no 128 0.00231258702428224 78 94870 An apoptosis inducer which activates caspases.
SGTC_343 4130-2827 29.8 µM 2.82538180576398 0.00447127652880358 no 129 0.00236121535285272 90 1118244
SGTC_3046 9092212 49.47 µM 2.81572253931189 0.00458994943439643 no 130 0.00243338389273043 38 25236637
SGTC_422 cantharidin 155 µM 2.7947492748209 0.00485735250895983 no 131 0.00259699902292059 137 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1307 1187-1599 12.2 µM 2.73019491597539 0.00576963115938717 no 132 0.00316484445218662 63 1538471
SGTC_1799 st045822 46.1415 µM 2.72852805336757 0.00579507817398547 no 133 0.00318088393914773 68 3674992
SGTC_2679 rapamycin 1 nM 2.70182949958837 0.00621646050873889 no 134 0.00344795572768712 261 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1669 st015249 58.4 µM 2.69160767291843 0.00638483942055918 no 135 0.00355542702275207 48 722793
SGTC_13 0199-0087 65 µM 2.6652104923052 0.00683847511872426 no 136 0.00384700736552084 67 4589825
SGTC_1625 st003711 30.1 µM 2.65738005651311 0.00697840699660205 no 137 0.00393753038540636 121 24207034 YER133W GLC7
SGTC_371 0195-0006 7.36 µM 2.63492038359715 0.00739388676961859 no 138 0.00420785101877632 92 3928593
SGTC_3101 9120531 49.47 µM 2.63308046614991 0.00742887019252861 no 139 0.00423071491698678 124 24824904
SGTC_2090 5301565 104.445 µM 2.61345229962277 0.00781124573343627 no 140 0.00448162973247277 137 2056344
SGTC_3306 9127676 59.7925 µM 2.60737584455251 0.00793308022991205 no 141 0.00456195758006239 101 41905287
SGTC_184 1494-0393 24.714 µM 2.60028998683321 0.00807726146920588 no 142 0.00465725062605834 163 3090647
SGTC_2343 7990716 14.84 µM 2.59512506057089 0.00818380242837516 no 143 0.00472782532946287 91 6456862
SGTC_309 k408-0051 1.48 µM 2.58782727063979 0.0083364437229123 no 144 0.00482916993283787 175 3640463
SGTC_146 3448-8650 53.125 µM 2.58439668366635 0.00840905800434871 no 145 0.00487747629779517 266 2891488 YIL048W NEO1
SGTC_2418 pentamidine 31.67 µM 2.57370476318547 0.00863894475689282 no 146 0.00503080449576926 132 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2742 clothiapine 36.27 µM 2.57260447587471 0.00866291195928577 no 147 0.00504682430476355 72 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_214 4373-3496 70 µM 2.56952809639508 0.0087302334598752 no 148 0.00509185666943755 193 3779166
SGTC_2795 7780010 54.55 µM 2.56759245732988 0.00877282645253433 no 149 0.00512037377806524 114 953673
SGTC_313 3474-0040 5.03 µM 2.55382196665131 0.00908113330011099 no 150 0.00532738601068933 191 1043375 YIL048W NEO1
SGTC_301 4119-0100 24.5 µM 2.55062770092398 0.00915399078718014 no 151 0.00537645614223824 175 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2461 5755302 26.15 µM 2.55053255212407 0.00915616884673999 no 152 0.00537792395585639 131 2788904
SGTC_1186 1319-0216 26 µM 2.55048597684054 0.00915723517103988 no 153 0.00537864257965801 110 4565136
SGTC_1357 1503-1303 39.5 µM 2.54236629210663 0.00934480196923865 no 154 0.00550523594598867 141 292895
SGTC_1292 0kpi-0043 232 µM 2.53270455046244 0.00957236269881802 no 155 0.00565931546408968 99 3333905
SGTC_3231 9132313 49.47 µM 2.52880826820794 0.00966549267815314 no 156 0.00572252650559187 77 4905967
SGTC_1438 4092-1045 4 µM 2.52566898274996 0.00974110372742142 no 157 0.00577391152278266 69 1351342
SGTC_852 0418-0143 439 µM 2.50429204520941 0.0102698515120746 no 158 0.0061348354822782 186 5369229
SGTC_738 1315-0003 72.4 µM 2.49459003747435 0.010517970519385 no 159 0.00630513647430966 119 6251474
SGTC_1316 1272-0050 65.9 µM 2.48950496666142 0.0106500902744869 no 160 0.00639605655971989 82 7340392
SGTC_1574 spiramycin 23.7 µM 2.48909379438183 0.0106608361984636 no 161 0.00640345869195735 133 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1062 mesoridazine 14.2 µM 2.48292892227997 0.0108230900020854 no 162 0.00651535427058417 106 4078 A neuroleptic.
SGTC_2270 7924575 90.91 µM 2.482445437463 0.0108359053056637 no 163 0.00652420246672726 113 1262135
SGTC_1346 1488-2224 62.4 µM 2.47976283816646 0.0109072508030715 no 164 0.00657348972681914 92 3722427
SGTC_2921 7974240 10.71 µM 2.47687079805395 0.0109846240854046 no 165 0.00662699357535994 162 2979074 YDR527W RBA50
SGTC_535 2293-4129 48.2 µM 2.46927880585709 0.0111900154533137 no 166 0.00676928447882249 187 396118 YIL048W NEO1
SGTC_567 1080-0542 68.4 µM 2.46228705430717 0.0113821132977871 no 167 0.00690270626945915 88 5950415
SGTC_2111 5486399 200 µM 2.45498897413138 0.011585677563616 no 168 0.00704444547992632 181 689674
SGTC_773 4358-1457 44.6 µM 2.4522632192554 0.0116625134769808 no 169 0.00709803873367149 158 1186886
SGTC_563 tetrahydrosecaminediol 614 µM 2.44786600441661 0.0117873984300948 no 170 0.00718525438691679 128 334274 A psychoactive constituent of the cannabis plant.
SGTC_149 3970-0822 46.1 µM 2.44258229842672 0.0119389941178614 no 171 0.00729130216252048 262 3114250 YBL034C STU1
SGTC_662 k832-1615 104 µM 2.43673053295821 0.0121088588787266 no 172 0.00741035953552795 127 5878478
SGTC_1927 st060202 13.8 µM 2.42835372865673 0.0123556648159116 no 173 0.00758377097038037 117 688887
SGTC_1870 st057514 26.5 µM 2.41508389512486 0.0127555531941373 no 174 0.00786579287373007 142 5393161
SGTC_1778 st046819 58.9 µM 2.40916893726415 0.0129373790575306 no 175 0.00799444746411333 155 671715
SGTC_414 piperonyl butoxide 100 µM 2.40861337754693 0.0129545715456935 no 176 0.00800662580856468 97 5794 A potent inhibitor of cytochrome P450.
SGTC_1287 0971-0001 34.6 µM 2.40517091233625 0.0130615439976429 no 177 0.00808245187057469 174 4665869
SGTC_781 4335-2806 94.4 µM 2.40287181571421 0.0131334114944107 no 178 0.00813344417418838 128 845254
SGTC_2235 salicylic acid 500 µM 2.4013771979282 0.0131803148448753 no 179 0.00816674514763747 57 338 A COX inhibitor and kinase inhibitor.
SGTC_488 nitrendipine 139 µM 2.3940037046422 0.0134138302782343 no 180 0.00833279023045888 149 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1294 1000-1494 117 µM 2.39122354420472 0.0135027996487361 no 181 0.00839616253485523 140 712797 YDL207W GLE1
SGTC_2408 sulbentine 18.36 µM 2.38527106969268 0.0136950022343483 no 182 0.00853327042125872 167 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2043 5101342 149 µM 2.38416722525489 0.0137309031093052 no 183 0.00855891092574694 139 678451
SGTC_2561 acetosyringone 100 µM 2.38221499180846 0.0137945953437103 no 184 0.00860442363600646 160 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2796 7949634 45.45 µM 2.37980527265175 0.0138735644503654 no 185 0.00866089442292867 133 2971588
SGTC_2380 9035439 200 µM 2.37660160894254 0.0139791554059356 no 186 0.00873647414328467 148 6462575
SGTC_2555 cholic acid 100 µM 2.3712052716203 0.0141585821492551 no 187 0.00886509050690633 107 6708657 Influences liver metabolism.
SGTC_2113 5491891 107.031 µM 2.36952107205265 0.0142149860830547 no 188 0.00890557005759594 143 789979
SGTC_3033 9090887 49.47 µM 2.36469249014614 0.0143777697822688 no 189 0.00902252360023387 163 19325384
SGTC_1949 st076024 69.1 µM 2.35780346953147 0.0146127933977418 no 190 0.00919171129378391 155 2921930
SGTC_505 gw-5074 63.9 µM 2.35503246245963 0.0147082563050458 no 191 0.00926054380672211 165 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1226 3909-7979 35.4 µM 2.35416772684875 0.0147381566033456 no 192 0.00928211620442883 162 6615510
SGTC_3137 9097352 49.47 µM 2.35351177094967 0.0147608727045689 no 193 0.00929850953084417 192 44120435
SGTC_517 1365-0151 113 µM 2.35239410501587 0.0147996474428295 no 194 0.00932650004690867 151 768657
SGTC_2580 diallyl disulphide 81.36 µM 2.35099975508659 0.0148481438530597 no 195 0.00936152308911142 134 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_401 neomycin 50 µM 2.33166365205274 0.0155348815893509 no 196 0.00985919620250298 111 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_844 0330-0132 15.3 µM 2.32614986477434 0.0157356350189801 no 197 0.0100052785867605 113 2828079
SGTC_2697 mebhydrolin 72.4 µM 2.31017095113822 0.0163300318518194 no 198 0.0104393458008046 226 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_397 arbidol 50 µM 2.29933617443485 0.0167439246628986 no 199 0.0107429285945637 148 131410 A RNA synthesis inhibitor.
SGTC_1178 0988-0033 191 µM 2.28954512492061 0.0171256333806518 no 200 0.011023849592997 199 5392207
SGTC_2640 pentamidine 10.38 µM 2.28708953577224 0.0172225239077178 no 201 0.0110952987724003 182 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3211 9128781 49.47 µM 2.28355715046072 0.0173627229331888 no 202 0.0111987852464106 218 17194361
SGTC_1327 1436-0082 2.18 µM 2.2802660546233 0.0174942212459862 no 203 0.0112959568917373 149 15992205
SGTC_565 1418-0001 44.5 µM 2.27350385993503 0.0177670801221113 no 204 0.011497916891936 179 2862145
SGTC_1603 st002045 67.8 µM 2.2647607643517 0.0181252447555834 no 205 0.01176368218121 133 5887985
SGTC_127 0180-0333 59.125 µM 2.26407278112836 0.0181536876464955 no 206 0.0117848193773945 221 771601
SGTC_1568 digitonin 820 nM 2.25614236018008 0.0184843063409426 no 207 0.0120308584887805 178 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1373 2887-0003 58.5 µM 2.2509049043307 0.0187054556200564 no 208 0.0121957805295556 170 776948
SGTC_3155 9099265 49.47 µM 2.24610866236682 0.0189099462208609 no 209 0.0123485243196105 150 25236499
SGTC_2520 obtusaquinone 4.71 µM 2.21567631094038 0.0202522510386824 no 210 0.013356839205188 143 5967872
SGTC_571 k831-0106 44.2 µM 2.21254497054821 0.020394842844783 no 211 0.0134645162615412 144 4783639
SGTC_389 tpck 16.7 µM 2.21141679293636 0.0204464247313491 no 212 0.0135034940064397 171 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1789 tunicamycin 25 nM 2.18707659400122 0.0215865066244878 no 213 0.0143684664952552 192 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1474 0330-0125 5.35 µM 2.18587000849998 0.0216443929262842 no 214 0.0144125585101235 143 X1474
SGTC_349 k015-0014 24 µM 2.17678930854229 0.0220842641304697 no 215 0.0147481455634014 173 2196908
SGTC_1007 4101-0031 70 µM 2.17562358401278 0.0221412748402368 no 216 0.014791709188541 165 1146276
SGTC_413 propylparaben 100 µM 2.16611567004215 0.0226109213225479 no 217 0.0151511745292203 152 7175 A pharmaceutical preservative.
SGTC_2807 7945238 51.95 µM 2.15888722298012 0.0229735675182027 no 218 0.0154294586805657 205 17148797
SGTC_46 0329-0187a 2.197 µM 2.15884689806171 0.0229756042526411 no 219 0.0154310233546903 271 46494817
SGTC_195 4234-0266 16.654 µM 2.15263331158594 0.0232912630524375 no 220 0.015673754194615 225 2303354
SGTC_595 3909-8003 73.7 µM 2.15122672256228 0.0233632241820054 no 221 0.0157291543992382 174 699517
SGTC_684 1140-0066 328 µM 2.14395855408922 0.0237380516425052 no 222 0.0160181039062762 219 6813534
SGTC_562 3772-2733 112 µM 2.12633319050416 0.0246680545651718 no 223 0.0167377631585939 251 2876874 YIL048W NEO1
SGTC_1667 st014849 34.6 µM 2.11995922949596 0.0250118183935155 no 224 0.0170047418553638 155 5348460
SGTC_3090 9117696 49.47 µM 2.11518265892904 0.0252720556790008 no 225 0.0172071911666236 154 7923821
SGTC_598 3937-0236 20.2 µM 2.11513210756454 0.0252748219060589 no 226 0.0172093446916083 217 1379313
SGTC_1991 st073000 8.92 µM 2.10692473483795 0.0257273149272797 no 227 0.0175620520897255 277 4301969 YIL048W NEO1
SGTC_1651 st011928 86.1 µM 2.0966514987743 0.0263032405705801 no 228 0.0180122184496205 164 720198
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.07634661665897 0.02747327325409 no 229 0.0189309523698355 214 688664
SGTC_513 4245-1575 41.7 µM 2.07415762489898 0.0276019621892335 no 230 0.0190323371292087 362 719745
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.07358476028916 0.0276357232359371 no 231 0.0190589458777954 206 390807
SGTC_3041 9091929 49.47 µM 2.07261173803023 0.0276931459396147 no 232 0.0191042138777487 202 25236887
SGTC_2594 a-mangostin 100 µM 2.07256869302784 0.0276956885263651 no 233 0.0191062185738961 221 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2457 5731572 11.68 µM 2.06865229811102 0.0279278379744371 no 234 0.0192893632648039 140 2865357
SGTC_1194 1488-0194 225 µM 2.06716418694187 0.0280164716232636 no 235 0.0193593427718279 223 1391452
SGTC_168 3970-0862 530.542 µM 2.06559288803456 0.0281103141733393 no 236 0.019433468268583 429 3135186
SGTC_1982 st072467 71.9 µM 2.06026403454324 0.0284305197278322 no 237 0.0196866531022607 256 3163533
SGTC_2238 6671620 73.2395 µM 2.0511453349534 0.0289854912529786 no 238 0.0201263977673715 202 729941
SGTC_1706 st031321 9.9705 µM 2.04995431057158 0.0290586383124583 no 239 0.0201844447895479 157 6103185
SGTC_2952 9073731 13.78 µM 2.04626221415296 0.0292863646484797 no 240 0.0203652896004232 249 16457353
SGTC_972 1319-0219 195 µM 2.04256994256483 0.0295155820975809 no 241 0.0205475145437717 199 23903702
SGTC_446 go6976 132 µM 2.0416546421114 0.0295726340269465 no 242 0.0205929004965038 168 3501 A protein kinase C inhibitor.
SGTC_1497 4476-2978 41.3 µM 2.04094011023022 0.0296172353678704 no 243 0.020628390166277 250 1528379
SGTC_1762 st045503 25.4615 µM 2.03917214572974 0.029727832359351 no 244 0.0207164249089805 219 4645554
SGTC_2396 5342950 42.78 µM 2.03686102903113 0.0298729233884845 no 245 0.0208319852087221 271 1886677
SGTC_1760 st045453 10.4495 µM 2.02146594094507 0.0308544791096839 no 246 0.021615777311646 319 3323419 YIL048W NEO1
SGTC_1844 rapamycin 4 nM 2.0198359042115 0.0309599519035336 no 247 0.0217002057727927 394 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1335 1486-0900 202 µM 2.01329032434829 0.0313864978225892 no 248 0.0220420478319157 254 X1335
SGTC_79 0052-0007 94.094 µM 2.00462713544766 0.0319584987422837 no 249 0.0225014617280733 222 2801472
SGTC_408 cantharidin 100 µM 1.99950189557296 0.032300935460762 no 250 0.0227770384865478 239 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2056 5235370 200 µM 1.99934611897712 0.0323113907186469 no 251 0.0227854587085357 242 5511916
SGTC_2175 5807670 165.306 µM 1.99815727733729 0.0323912742235277 no 252 0.0228498058278963 199 241186
SGTC_2371 9071574 200 µM 1.99448753559468 0.0326388887792083 no 253 0.0230494003931567 169 45596039
SGTC_2365 9042475 200 µM 1.98470004402182 0.0333069387035523 no 254 0.0235889269618832 250 6464479
SGTC_2311 7694451 200 µM 1.9788363775483 0.0337125323409779 no 255 0.02391721566214 227 2163142
SGTC_683 panaxydol 45 µM 1.96827457400602 0.0344533495325411 no 256 0.024518226908382 241 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2754 granisetron 64.02 µM 1.96691524474654 0.0345496586836562 no 257 0.0245964913593813 254 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2608 thymoquinone 42.66 µM 1.96492218975244 0.0346912673573299 no 258 0.0247116220188845 203 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_52 0329-0193 875 nM 1.96084054074852 0.0349827606027629 no 259 0.0249488135999497 239 3739292
SGTC_1076 itraconazole 331 nM 1.96024887154876 0.0350251813323188 no 260 0.0249833544067328 229 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_404 fumagillin 50 µM 1.95991089976719 0.0350494317324384 no 261 0.0250031027046607 242 12015870 A methionine aminopeptidase binder.
SGTC_3341 9147222 25.867 µM 1.95919597444026 0.0351007749827065 no 262 0.0250449201995595 211 1939759
SGTC_2304 7443016 91.4 µM 1.94927804182933 0.0358194314105882 no 263 0.0256311147027026 191 939854
SGTC_578 3460-0051 92 µM 1.94816023031462 0.0359011790034189 no 264 0.025697896899152 250 2876744
SGTC_253 dyclonine 31.25 µM 1.93944293869715 0.0365439472147837 no 265 0.0262237131602652 259 3180 An oral anasthetic.
SGTC_2598 perillyl alcohol 100 µM 1.93507705424965 0.0368693864083515 no 266 0.0264904204000367 267 10819 An apoptosis inducer.
SGTC_1997 st073024 93.8 µM 1.93107712259051 0.03716962337083 no 267 0.0267367578468826 218 686268
SGTC_491 tetrandrine 80.3 µM 1.92941663597165 0.0372948458123485 no 268 0.0268395800439766 176 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1846 st056244 14.8 µM 1.92890776432306 0.0373332903222308 no 269 0.0268711568833231 265 5393182
SGTC_236 1509-0011 5.31 µM 1.92229012448145 0.0378361975414838 no 270 0.0272846309627071 621 3107280
SGTC_900 1112-0045 141 µM 1.92217756112118 0.0378447993733555 no 271 0.0272917096342898 178 56211 YIL048W NEO1
SGTC_449 xestospongin c 11.1929 µM 1.92038259998878 0.0379821819088234 no 272 0.0274047948777866 300 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_723 4182-0001 115 µM 1.91438166030739 0.0384444378468695 no 273 0.0277857035784398 230 744821 YLR208W SEC13
SGTC_2489 cantharidin 73.42 µM 1.90856847345686 0.0388965936273426 no 274 0.0281588910687956 304 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2534 helenine 20.12 µM 1.9043500459057 0.0392274115086305 no 275 0.0284323052205982 196 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3267 9137951 49.47 µM 1.90124252504018 0.0394725715994219 no 276 0.0286351267054446 158 16643986
SGTC_2771 fluoxetine 41.05 µM 1.89235596143207 0.0401805398753493 no 277 0.0292217847123452 227 3386 A selective serotonin reuptake inhibitor.
SGTC_2467 5474540 200 µM 1.89215055768279 0.0401970250059322 no 278 0.0292354618796596 269 5413519
SGTC_179 1273-0063 6.77 µM 1.89194814174423 0.0402132757175581 no 279 0.029248945299659 224 3108139
SGTC_3240 9133527 49.47 µM 1.88772638652289 0.0405534321465717 no 280 0.0295313460559768 226 17617455
SGTC_1056 3448-1962 115 µM 1.88687286944853 0.0406224850014427 no 281 0.029588713510537 237 715507
SGTC_386 1509-0011 3.07 µM 1.88550449805224 0.0407333906970959 no 282 0.0296808788692338 388 3107280
SGTC_233 rapamycin 362 pM 1.88086191971202 0.0411115011291377 no 283 0.0299953522466824 232 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2004 4023728 41.89 µM 1.87244235273887 0.0418044830521303 no 284 0.0305727151242966 291 360084 YDR527W RBA50
SGTC_1903 st060211 78.3 µM 1.86528489737224 0.042400997014581 no 285 0.0310707404666531 285 688960
SGTC_1955 wogonin 32.4 µM 1.86151834098185 0.0427176620286652 no 286 0.0313355065070877 245 5281703 A flavanone.
SGTC_196 k015-0023 18.111 µM 1.86042443714582 0.0428099870047438 no 287 0.0314127499794479 278 5211998
SGTC_1225 1216-0074 20.6 µM 1.85525020457434 0.0432488776528066 no 288 0.0317802527134012 252 4241466
SGTC_782 0083-0095 30.5 µM 1.85313315198535 0.0434294953971809 no 289 0.0319316380742272 314 3591729 An indicator and reagent.
SGTC_3233 9132340 49.47 µM 1.85303107273833 0.0434382197213017 no 290 0.0319389525418533 242 17682950
SGTC_1770 st043884 66.3 µM 1.8528441254793 0.0434542010590566 no 291 0.0319523517972374 250 670149
SGTC_2695 st077686 51.995 µM 1.85092175324574 0.0436188120956954 no 292 0.0320904053772854 257 2876092
SGTC_960 1222-0186 7.7 µM 1.85025528972564 0.0436759981132603 no 293 0.0321383817175547 279 3126296
SGTC_2745 rifampicin 24.3 µM 1.84797915881191 0.0438717581763432 no 294 0.0323026789281323 136 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3355 9151058 44.0485 µM 1.84582275385826 0.0440578734117307 no 295 0.0324589728116113 254 17015728
SGTC_2141 5621638 7.665 µM 1.84146643745112 0.0444358008692325 no 296 0.0327766172963067 238 2856238
SGTC_2581 avocatin a 64 µM 1.84121955390643 0.0444572969526232 no 297 0.032794695485694 312 6710728 A skin care supplement.
SGTC_2142 5622915 118.518 µM 1.83994787688636 0.0445681542886317 no 298 0.0328879450342808 220 5322196
SGTC_2560 caryophyllene 100 µM 1.83304911808717 0.0451734338876511 no 299 0.0333976334536348 302 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_274 sirtinol 40.1 µM 1.83149194243397 0.045310967423225 no 300 0.0335135746387375 262 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2434 5670830 169.91 µM 1.82885357827437 0.0455447628140503 no 301 0.0337107730428605 303 1549830
SGTC_2997 9067075 71.4286 µM 1.82740196915552 0.0456738084312557 no 302 0.0338196767478345 313 27209819
SGTC_1086 cerivastatin 2.18 µM 1.82608673360528 0.0457909843144648 no 303 0.0339185991005921 221 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_564 3555-0129 330 µM 1.82538097493489 0.0458539607198312 no 304 0.0339717791233802 187 563260
SGTC_1006 4099-6547 255 µM 1.82354386539918 0.046018216484121 no 305 0.0341105298436703 279 3146833
SGTC_644 1498-1197 63.3 µM 1.82341566364185 0.046029696610616 no 306 0.0341202298592794 304 6741615
SGTC_159 3970-0959 50 µM 1.81738358817959 0.0465724587840591 no 307 0.0345791994678934 506 6615653
SGTC_2189 6047310 154.431 µM 1.81550356095966 0.0467426683485791 no 308 0.034723279613296 262 711535
SGTC_378 3970-0959 8.33 µM 1.80793600535184 0.0474328556159926 no 309 0.0353082305738173 279 6615653
SGTC_1251 0490-5699 265 µM 1.80647668706472 0.0475668849764193 no 310 0.035421956222569 328 3883818
SGTC_636 0kpi-0074 126 µM 1.80484540938918 0.0477170666551249 no 311 0.0355494381544292 261 616434
SGTC_1323 1348-1351 11.2 µM 1.80310770045265 0.0478774642370584 no 312 0.0356856510222342 241 6989654
SGTC_493 zm226600 134 µM 1.79998961565103 0.048166358010976 no 313 0.0359311389665831 287 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2747 doxorubicin 7.63 µM 1.79061202831953 0.0490436135566043 no 314 0.0366777877361513 152 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.78755970795223 0.0493318899612365 no 315 0.0369235354744886 361 91467 include heat shock
SGTC_2277 7947813 106.88 µM 1.78561454262277 0.0495163058117808 no 316 0.0370808453027273 303 1246798
SGTC_2517 totarol 10 µM 1.78294014022346 0.0497707565031307 no 317 0.0372980240064832 273 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2890 9046729 58.44 µM 1.77847158791884 0.0501982344553154 no 318 0.0376632171418965 256 903329
SGTC_1136 pergolide 1.05886 µM 1.77682494773729 0.0503564940437823 no 319 0.0377985229235111 403 47811 A dopamine receptor agonist.
SGTC_87 0100-0052 35.5 µM 1.77539754851595 0.0504940037452623 no 320 0.0379161342574522 541 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1411 3909-8223 150 µM 1.77514458904265 0.0505184039852555 no 321 0.0379370081053784 286 X1411
SGTC_2818 7996756 12.99 µM 1.7614747618737 0.0518510107700823 no 322 0.0390790405031543 211 2241621
SGTC_42 0133-0086 60.653 µM 1.75804601531482 0.0521896078726803 no 323 0.039369840059462 281 162923 Model of phenazepam hydroxylation.
SGTC_1754 st042065 16.137 µM 1.75160642763521 0.0528302772612292 no 324 0.0399207532886954 499 1126236 YIL048W NEO1
SGTC_968 1309-0633 340 µM 1.75152801200248 0.0528381170461729 no 325 0.0399275002411117 284 3761976
SGTC_14 0354-0009 295 µM 1.74997293029528 0.0529937806614744 no 326 0.0400614924206811 311 1713507
SGTC_667 1498-1044 59 µM 1.74903587578424 0.0530877552427961 no 327 0.0401424091158501 303 6739982
SGTC_115 0527-0192 112.043 µM 1.74459635793023 0.0535347793866745 no 328 0.0405275776295518 415 4233931
SGTC_2273 7815444 169.05 µM 1.74435996214108 0.0535586659371274 no 329 0.0405481709530071 303 2824616
SGTC_1185 1319-0113 81.3 µM 1.74151080686439 0.0538472227094581 no 330 0.0407970403164468 274 4672763
SGTC_1258 0671-0043 57.1 µM 1.74066194280227 0.0539334315774068 no 331 0.0408714264616173 327 4298767
SGTC_1356 1502-0781 85.8 µM 1.73992179523774 0.0540086885664489 no 332 0.0409363755168061 305 567702
SGTC_311 1315-0136 58 µM 1.72783818440567 0.05524912412012 no 333 0.0420086197018429 275 6759207
SGTC_3224 9130643 49.47 µM 1.72718877750942 0.0553164204979418 no 334 0.0420668828372305 318 17644395
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.71993371952591 0.0560726525172781 no 335 0.0427222451667724 318 66535 A nucleotide analog.
SGTC_3174 9107204 49.47 µM 1.71716008793956 0.0563639077203823 no 336 0.0429749628894739 328 3938802
SGTC_2412 st077135 33.4 µM 1.71037867864582 0.057081036505575 no 337 0.0435979355589345 330 13258915
SGTC_3272 9137413 49.47 µM 1.70459327349411 0.0576984994076563 no 338 0.0441351533761951 297 17614870
SGTC_1695 st026914 34.495 µM 1.69927844807185 0.0582703558963947 no 339 0.0446333656834237 320 3289191
SGTC_210 3551-0445 56.827 µM 1.69695524748151 0.0585217183414647 no 340 0.0448525608610121 348 2865180 YOR207C RET1
SGTC_2833 9001315 45.46 µM 1.66893288641508 0.0616211426491135 no 341 0.047565340614869 381 2989378
SGTC_2193 5925765 200 µM 1.66556240802245 0.0620024147934453 no 342 0.0479003018872021 266 877370
SGTC_407 eburnamonine 100 µM 1.66200239294141 0.0624071239482001 no 343 0.0482561473425916 291 3195
SGTC_1970 st070122 35.8 µM 1.66144707000459 0.0624704393963584 no 344 0.0483118454829985 364 102928
SGTC_1892 st058411 7.36 µM 1.65296704154458 0.0634435283814732 no 345 0.0491687857116877 396 3934738
SGTC_1752 st044819 83.042 µM 1.64386458724767 0.0645011265620822 no 346 0.0501020882439376 352 441209 YML126C ERG13
SGTC_2960 9079389 5.97 µM 1.64346701041023 0.0645476306224317 no 347 0.0501431727498792 361 16457355
SGTC_3245 9134821 49.47 µM 1.64249167235216 0.0646618250027862 no 348 0.0502440752911597 371 17014901
SGTC_1710 st031758 61.5 µM 1.63995285084029 0.0649598107120301 no 349 0.0505074853419043 297 5394341
SGTC_2726 cimetidine 79.27 µM 1.63760151453423 0.0652367407384882 no 350 0.0507524234636274 269 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1067 clotrimazole 1.36 µM 1.63634505026653 0.0653850966012334 no 351 0.0508836962809003 382 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2667 digitoxin 100 µM 1.63460281632161 0.065591242118684 no 352 0.051066168444014 232 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_421 streptovitacin 30 mM 1.63384541961113 0.0656810162171666 no 353 0.0511456563151058 391 91467 include heat shock
SGTC_1660 st012960 28.1 µM 1.63067195814056 0.0660582021134204 no 354 0.0514797783062145 382 24207266
SGTC_259 usnic acid 108.925 µM 1.62842170102057 0.0663266746606034 no 355 0.0517177496222121 368 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3128 9127691 49.47 µM 1.62147872875671 0.0671603502188497 no 356 0.0524575041435107 310 41316314
SGTC_2698 st077697 67.5 µM 1.6177441947321 0.0676121123960379 no 357 0.0528588686857208 340 3154499
SGTC_992 3909-8734 162 µM 1.61717645970094 0.0676809957513859 no 358 0.0529200980785299 349 4288319
SGTC_2626 ethyl orsellinate 100 µM 1.61683739311797 0.0677221605888287 no 359 0.0529566927364958 329 75653 A natural product.
SGTC_924 2046-0044 21.3 µM 1.60897222546999 0.0686824792804213 no 360 0.0538112074862238 362 3623589
SGTC_2271 7849410 118.62 µM 1.60613361469911 0.0690316344828044 no 361 0.0541222777606796 341 972430
SGTC_2958 9077254 16.72 µM 1.59954193850838 0.0698477002159407 no 362 0.0548501188840712 341 16457351
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.59950412006473 0.0698524035601509 no 363 0.0548543169394676 441 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2236 dapsone 200 µM 1.59511314009846 0.0704001527936468 no 364 0.0553434687984635 372 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3291 9121177 71.43 µM 1.5899446539316 0.0710491158502788 no 365 0.0559236405286613 308 17015612
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.58865957060218 0.0712111838637683 no 366 0.0560686356089486 371 140250 A respiratory chain inhibitor.
SGTC_192 3455-0609 60.9 µM 1.58783607695897 0.0713151877139807 no 367 0.0561617055965789 359 3769639
SGTC_1047 2043-3044 82 µM 1.58666063251144 0.0714638434480462 no 368 0.0562947635126661 394 669592
SGTC_2379 9035213 200 µM 1.58599376364221 0.0715482864712764 no 369 0.0563703621254757 394 646551
SGTC_559 1550-0661 158 µM 1.58598120241407 0.0715498777852994 no 370 0.0563717868781787 362 5830875
SGTC_1818 st052136 56.3 µM 1.5840945037768 0.0717892019383555 no 371 0.056586107477403 394 674169
SGTC_2937 9044753 11.33 µM 1.58175632630794 0.0720866467003835 no 372 0.0568526043265386 426 6465530 YGL099W LSG1
SGTC_975 1335-0046 28.5 µM 1.5797848495198 0.0723381759993056 no 373 0.0570780731881126 405 16486740
SGTC_100 0086-0128 49.5915 µM 1.57772715702667 0.0726014217543016 no 374 0.0573141522970329 445 93297
SGTC_35 0133-0054 64.071 µM 1.57651479298482 0.0727568656614922 no 375 0.0574536061521815 373 99677
SGTC_1473 k844-0725 134 µM 1.57624881832351 0.0727910018069118 no 376 0.0574842359315762 420 54682906
SGTC_3271 9137798 49.47 µM 1.57516766875356 0.0729298866764913 no 377 0.0576088739240365 296 6498326
SGTC_737 1950-0117 57.9 µM 1.57340922503004 0.0731562101281529 no 378 0.0578120461552833 380 5393513
SGTC_2751 anetholtrithion 17.25 µM 1.5710283181916 0.0734635046772102 no 379 0.0580880355941998 401 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2705 st078069 42.8 µM 1.57054642297459 0.0735258209974595 no 380 0.0581440215963306 354 1530061
SGTC_328 k915-0120 63.5 µM 1.56703323988202 0.0739813506945759 no 381 0.0585534611245222 378 6624543
SGTC_2642 cholecalciferol 100 µM 1.56372081990725 0.0744128209193295 no 382 0.0589415730704575 345 9821465 A vitamin D precursor, similar to steriods.
SGTC_355 1311-2252 105 µM 1.56291849309133 0.0745176191246625 no 383 0.0590358836484644 407 5338538
SGTC_1547 harmine 94.2 µM 1.56287995197419 0.0745226561171144 no 384 0.0590404169936832 466 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2610 ononetin 44.17 µM 1.55922251796842 0.0750018348234768 no 385 0.0594718614922156 444 259632
SGTC_84 0443-0269 128.823 µM 1.55831957174135 0.0751204952350856 no 386 0.0595787558389203 406 6150058
SGTC_2421 5690543 90.72 µM 1.55695627154831 0.0752999240912089 no 387 0.0597404339324763 386 3397993
SGTC_466 geldanamycin 89.2 µM 1.55477042642503 0.0755882926386097 no 388 0.0600003774029509 272 5288382 HSP90 inhibitor.
SGTC_2075 5212009 200 µM 1.55412349716518 0.0756738002186374 no 389 0.0600774806786382 338 780898
SGTC_718 1130-0073 349 µM 1.55410449111157 0.0756763134488956 no 390 0.0600797470586563 401 6740020
SGTC_2836 9010338 19.48 µM 1.551959201013 0.0759604007524751 no 391 0.0603359930396509 371 2994051
SGTC_860 0443-0016 25.1 µM 1.54981246806356 0.0762454912474616 no 392 0.0605932667934254 386 5337942
SGTC_2450 5739737 12.93 µM 1.54460992207111 0.0769397772755054 no 393 0.061220322383029 378 2262825
SGTC_2350 9023895 38.85 µM 1.54266929680245 0.0771999830916444 no 394 0.061455517526061 403 2997209
SGTC_3236 9132701 49.47 µM 1.54198421712632 0.0772920004729851 no 395 0.06153871447936 376 24282524
SGTC_234 nsc-17383 10.7 µM 1.53637263188911 0.0780488668726459 no 396 0.0622235075349299 457 408974
SGTC_891 0929-0073 133 µM 1.53368387146282 0.0784135018136309 no 397 0.062553721745546 374 5603632
SGTC_3028 9087778 49.47 µM 1.53187319452657 0.0786597826889853 no 398 0.0627768647157004 377 17217395
SGTC_2484 5809818 12.04 µM 1.53175531991231 0.0786758358127185 no 399 0.0627914127440633 385 2870548
SGTC_988 1497-1057 103 µM 1.53134184405735 0.0787321659472837 no 400 0.0628424645065019 418 3533044
SGTC_1749 st037932 54.2 µM 1.52706625672412 0.0793164463342427 no 401 0.0633722682974537 398 594497
SGTC_1222 0366-0074 1.18 µM 1.52605160658591 0.0794555840376306 no 402 0.0634985063687098 412 286520
SGTC_3210 9128157 49.47 µM 1.52552082063433 0.0795284436021526 no 403 0.0635646222204855 415 17590849
SGTC_1683 st010134 710 nM 1.52456483406875 0.079659796827073 no 404 0.0636838370987943 417 3818134
SGTC_1888 azatryptophan 97.5 µM 1.52350585591926 0.0798054927027895 no 405 0.0638160983806895 351 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2086 5274770 176.623 µM 1.51577374661991 0.0808754026754794 no 406 0.0647882863226953 397 689278
SGTC_1460 k062-0059 9.15 µM 1.51407088472494 0.0811124800606605 no 407 0.0650039310762392 391 1373085
SGTC_31 0508-1974 57.237 µM 1.51202770148032 0.0813976296624235 no 408 0.0652634077719704 409 6810525
SGTC_997 3996-0078 137 µM 1.5103232535456 0.0816360827974974 no 409 0.0654804805121545 432 735687
SGTC_1106 tegaserod maleate 11.7 µM 1.5075577240371 0.0820241017526126 no 410 0.0658338798103254 445 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_804 1595-0054 20.9 µM 1.50264174776875 0.0827172680732001 no 411 0.0664657258628205 404 761523 Stimulates phospholipase C.
SGTC_3217 9129673 49.47 µM 1.5003664036987 0.0830395863219855 no 412 0.0667597585823969 427 17248312
SGTC_2403 6032726 181.2 µM 1.49988169171408 0.083108371018472 no 413 0.0668225256332709 420 2881040
SGTC_2488 5268135 45.7 µM 1.49977451845282 0.0831235855859627 no 414 0.0668364100357189 518 1270356 YLR208W SEC13
SGTC_990 3985-0011 41.3 µM 1.49827736804255 0.0833363436232515 no 415 0.0670306008098798 375 5399565 YGL099W LSG1
SGTC_2381 9035592 200 µM 1.49800089320267 0.083375677830238 no 416 0.0670665091960115 356 4749657
SGTC_2557 derrustone 83.84 µM 1.49587095087967 0.0836791737375647 no 417 0.067343643794678 482 629853 An antioxidant.
SGTC_205 1486-1330 71.903 µM 1.49577664426144 0.0836926306690054 no 418 0.0673559348086063 341 4118834
SGTC_3050 9093513 49.47 µM 1.49494420655802 0.0838114845497921 no 419 0.0674645019167338 406 25236664
SGTC_1618 st003135 44.5 µM 1.49385613612481 0.083967028282711 no 420 0.0676066126766978 391 1270615
SGTC_926 2268-1401 59.4 µM 1.49038354894184 0.0844648974622794 no 421 0.0680617077965722 441 2931578
SGTC_1408 3909-7976 48.8 µM 1.48909061123205 0.0846508323034128 no 422 0.0682317548987815 472 24152374
SGTC_2782 7736369 71.43 µM 1.48220467722172 0.0856462590202304 no 423 0.069142921220424 468 2950836 YOL077C BRX1
SGTC_1717 st033143 58.0435 µM 1.48177451585348 0.085708732521902 no 424 0.0692001510527823 478 674616
SGTC_3108 9121785 49.47 µM 1.48099679061067 0.0858217702561292 no 425 0.0693037143583336 416 17140271
SGTC_1837 st055472 66.5 µM 1.48056155763236 0.0858850774548559 no 426 0.0693617228533139 438 676091
SGTC_1674 st016616 23.6 µM 1.47933123572543 0.086064224050807 no 427 0.0695259042674833 436 625830
SGTC_986 1493-0483 84 µM 1.47452960657536 0.0867660622052323 no 428 0.0701695261487306 400 40079
SGTC_1276 0871-0068 94.2 µM 1.47178657316501 0.0871689170549021 no 429 0.0705392602588011 404 3414906
SGTC_1964 st076914 61 µM 1.46639105810372 0.0879654008842331 no 430 0.0712708904922992 406 24208661
SGTC_3292 9120825 59.784 µM 1.46569021458581 0.0880692561030819 no 431 0.0713663506106887 423 24824900
SGTC_605 1315-0399 119 µM 1.46478227183582 0.0882039364302494 no 432 0.0714901650772751 480 24020461
SGTC_2658 polymyxin b sulfate 77.05 µM 1.46298905229989 0.0884703858451665 no 433 0.0717351872998473 457 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1203 3992-3522 103 µM 1.4621302041793 0.0885982118440787 no 434 0.0718527666311184 485 5322312
SGTC_717 1532-0246 73.2 µM 1.45511488050566 0.0896474875200012 no 435 0.0728187301324467 464 9561992
SGTC_1104 tacrolimus 29.8 µM 1.45352014746366 0.0898872940278528 no 436 0.0730396949514099 478 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.45181539094091 0.0901441720973565 no 437 0.0732764716163932 518 688788
SGTC_1180 1193-0155 285 µM 1.45174417004294 0.0901549157415269 no 438 0.0732863763767704 441 2921347
SGTC_3127 9126946 49.47 µM 1.45111345789091 0.0902500999329762 no 439 0.0733741348365233 396 27243249
SGTC_2312 7706453 155.7 µM 1.45101234880041 0.090265365793628 no 440 0.0733882108155642 449 976098
SGTC_548 1436-0017 110 µM 1.44829906502794 0.0906757449959151 no 441 0.0737667145256365 551 9677137
SGTC_2385 9074692 200 µM 1.44626895463866 0.0909836999495372 no 442 0.0740508899110199 459 17046906
SGTC_800 3448-7362 155 µM 1.4452251835289 0.0911423351228098 no 443 0.0741973224332567 732 15991913
SGTC_2739 tacrine 100.86 µM 1.44021223300901 0.091907075950243 no 444 0.0749036816476788 410 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2232 chlorophetanol 41.5365 µM 1.43537315712881 0.092649789613006 no 445 0.0755903954663599 608 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.43214395145986 0.0931478801335953 no 446 0.0760513141298622 447 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1611 st001856 99.4 µM 1.42964751437633 0.0935342985858339 no 447 0.0764091055771966 445 647478
SGTC_2024 5144227 134 µM 1.4272013232463 0.0939140866825089 no 448 0.0767609366026769 505 3475211
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.42569222334539 0.0941489518262871 no 449 0.0769786011331335 417 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1236 0330-0013 258 µM 1.42529249478363 0.0942112351496198 no 450 0.0770363343656922 435 4617066
SGTC_2224 6650123 117.647 µM 1.42051281653813 0.0949583319821713 no 451 0.0777292200091848 413 2908370
SGTC_1369 1866-0067 208 µM 1.4158991697922 0.0956836079325464 no 452 0.0784025140323983 538 3531355
SGTC_1788 fluconazole 20 µM 1.41352598183881 0.0960582622451345 no 453 0.0787505637457306 464 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2172 5754775 163.918 µM 1.4124214468978 0.0962330021507004 no 454 0.0789129526036015 446 2263357
SGTC_1471 k673-0312 37 µM 1.40820206216243 0.0969026694531505 no 455 0.0795356229109552 458 24099884
SGTC_2910 7948405 25.97 µM 1.40797739088185 0.0969384231996007 no 456 0.0795688824458127 421 2971328
SGTC_1446 4239-0190 62 µM 1.40714772007388 0.0970705393009356 no 457 0.0796917951432413 519 1340085
SGTC_2785 7756463 72.73 µM 1.40633006221012 0.0972008717274214 no 458 0.0798130686437644 469 2201551
SGTC_1171 0368-0077 21.4 µM 1.4059885453952 0.0972553465750498 no 459 0.0798637630915726 433 3239779
SGTC_1350 1495-0454 146 µM 1.40534561004663 0.0973579610279824 no 460 0.0799592659033308 545 1069057
SGTC_2274 7947094 46.08 µM 1.40483437780319 0.0974396119326743 no 461 0.0800352669040066 496 2971028
SGTC_2873 9040596 71.43 µM 1.40450938125292 0.097491544513683 no 462 0.0800836100519596 485 6463863
SGTC_839 0122-0028 230 µM 1.404074454121 0.097561075128039 no 463 0.080148339877906 548 759448
SGTC_2788 5282734 71.43 µM 1.40371738994229 0.097618185182223 no 464 0.0802015109839819 543 743706
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.39925479513438 0.0983340165170069 no 465 0.0808682950833289 533 23847180
SGTC_2387 9077560 195.08 µM 1.39666333963133 0.0987514644701456 no 466 0.0812574166960719 487 5303272
SGTC_994 3910-0338 138 µM 1.39641666260944 0.0987912682559003 no 467 0.08129453014316 518 3479481
SGTC_1428 4049-0204 61.7 µM 1.39593653025945 0.0988687760385902 no 468 0.0813668044521299 491 X1428
SGTC_2296 7971656 126.45 µM 1.39298865533703 0.0993456269667934 no 469 0.0818116106477752 485 666570
SGTC_427 1354-0053 47.3 µM 1.39134107066274 0.0996128731425476 no 470 0.0820610125675264 483 6813657
SGTC_1910 st062352 60.4 µM 1.39040606011423 0.0997647698222712 no 471 0.0822028036429643 489 2245730
SGTC_307 1501-1223 22.3 µM 1.38897357008376 0.0999978123798615 no 472 0.0824203935529499 480 2830329
SGTC_560 2332-1943 155 µM 1.38886827907323 0.100014957164758 no 473 0.0824364039583003 471 21177716
SGTC_832 4083-0019 164 µM 1.38469653340862 0.100695980731458 no 474 0.0830726397694665 690 1990758
SGTC_16 erodoxin 22.806 µM 1.38091897817924 0.1013155663679 no 475 0.0836519369893871 568 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2025 5147754 141 µM 1.38059505061585 0.101368825212388 no 476 0.0837017529997389 457 315777 YLR208W SEC13
SGTC_282 k297-0036 65.7 µM 1.37772287965291 0.101841948168969 no 477 0.0841444322674556 437 5061378
SGTC_332 4112-0506 40.9 µM 1.37771471797296 0.101843294901095 no 478 0.0841456927025139 491 2790355
SGTC_3019 9081971 49.47 µM 1.37663525387275 0.102021527995659 no 479 0.0843125228197946 524 16451803
SGTC_1252 0493-0875 34.8 µM 1.37433292897879 0.102402428852574 no 480 0.0846691739707154 482 3960963
SGTC_2018 5133068 143 µM 1.37303397785284 0.102617785484038 no 481 0.0848708919955749 486 785362
SGTC_212 3807-4682 38.772 µM 1.37302672907787 0.102618988201114 no 482 0.0848720186896807 659 3125501 YBL034C STU1
SGTC_2183 6420625 130.508 µM 1.372665255352 0.102678976934549 no 483 0.0849282176226587 593 2897619
SGTC_2027 5150920 200 µM 1.37166654410357 0.102844851541991 no 484 0.085083633961282 479 786715
SGTC_1842 st055362 61.2 µM 1.37060226350476 0.103021830681991 no 485 0.0852494884927144 535 676032
SGTC_1512 0259-0544 12.2 µM 1.36943954018965 0.103215432599465 no 486 0.0854309608060527 538 18476
SGTC_3330 9141424 71.43 µM 1.36872561683121 0.103334436878801 no 487 0.0855425298410687 537 27261020
SGTC_72 0744-0168 198.391 µM 1.36640257133993 0.103722355961497 no 488 0.0859063210867775 492 677577
SGTC_1805 st050013 60.3 µM 1.3633302450193 0.104237016530393 no 489 0.0863892270602785 450 4037144
SGTC_2263 7948595 193.29 µM 1.36283503154335 0.104320145110663 no 490 0.0864672539315083 421 2971371
SGTC_3198 9112019 49.47 µM 1.362763266231 0.104332195917259 no 491 0.0864785657939792 483 45595555
SGTC_2665 lovastatin 100 µM 1.36140861448617 0.104559857855772 no 492 0.0866922976378217 491 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_574 1315-0397 40 µM 1.35845188663004 0.105058013217215 no 493 0.087160169806546 584 6794277
SGTC_2435 5706476 10.6 µM 1.35730940701091 0.105250959845205 no 494 0.0873414597905762 534 5725375
SGTC_799 1310-0557 151 µM 1.3558213410984 0.105502654783175 no 495 0.0875780097067573 525 5354492
SGTC_1432 4049-0298 68.4 µM 1.35496266123415 0.105648091819408 no 496 0.0877147268197509 480 741646
SGTC_1596 piperlongumine 63 µM 1.35485835035641 0.105665769117212 no 497 0.0877313458074203 546 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_791 1348-1292 225 µM 1.3504757636929 0.106410408374732 no 498 0.088431711375424 609 5437054
SGTC_3133 9127736 49.47 µM 1.34306682841242 0.107677854385477 no 499 0.0896251677436326 518 27243420
SGTC_2515 chrysin 20.77 µM 1.34158715585271 0.107932279510644 no 500 0.0898649465268963 517 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_21 0849-0113 22.993 µM 1.34068490394375 0.108087631255231 no 501 0.0900113889489727 542 1560156
SGTC_2458 5808907 16.39 µM 1.3404959062446 0.108120193682758 no 502 0.090042087178783 533 2731747
SGTC_3280 9140961 49.47 µM 1.3370875235734 0.108708636648402 no 503 0.0905970346096918 483 4901226
SGTC_345 1362-0200 395 µM 1.3332745844074 0.109369650009979 no 504 0.0912208555189814 491 1419823
SGTC_3205 9113483 49.47 µM 1.33304399500111 0.109409717504012 no 505 0.0912586832814426 562 17018033
SGTC_611 3453-1652 23.7 µM 1.33124641652243 0.109722428404031 no 506 0.0915539715010586 552 1560575
SGTC_379 3970-0972 5.9 µM 1.32810529254624 0.110270404761472 no 507 0.0920716626425739 520 2898042 YBL034C STU1
SGTC_118 0083-0097 135.343 µM 1.31809340063439 0.112030092920404 no 508 0.0937361917063627 770 5207356
SGTC_305 1682-2595 20.8 µM 1.3163011114573 0.112347212301572 no 509 0.0940364989845749 555 226033
SGTC_150 3970-0969 77.2 µM 1.31528026721667 0.112528122223349 no 510 0.0942078637096533 626 6615640
SGTC_2010 4012422 159 µM 1.31382016496444 0.112787237200506 no 511 0.0944533649855062 541 952393
SGTC_1935 st074532 41.6 µM 1.31376356797581 0.112797289674238 no 512 0.0944628906788662 628 2829742
SGTC_206 4546-0025 72.014 µM 1.31339965405947 0.11286194152207 no 513 0.0945241570129311 618 6620745 YIL048W NEO1
SGTC_889 0919-1524 82.7 µM 1.31210069988182 0.11309292552157 no 514 0.0947430799418283 501 3905452
SGTC_2493 resveratrol 26.09 µM 1.30653613181517 0.114086251625661 no 515 0.0956851500305701 492 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2000 st075254 36.4 µM 1.30575041876488 0.114227007748453 no 516 0.0958187230121491 492 17234175
SGTC_1463 k081-0032 34.1 µM 1.30349380258548 0.114631955532179 no 517 0.0962031154077619 432 977755
SGTC_587 k089-0003 57 µM 1.30323267223917 0.114678881010332 no 518 0.0962476694684272 385 9659696
SGTC_3356 9151811 4.48 µM 1.30277605821798 0.114760968015669 no 519 0.0963256133987679 548 1859254 YPR165W RHO1
SGTC_710 3448-4187 58 µM 1.29850955114492 0.115529992723558 no 520 0.0970561482176483 647 3946412
SGTC_1267 0828-0272 9.49 µM 1.29510803578833 0.116145723243495 no 521 0.097641481604212 583 745334
SGTC_2335 9018011 154.17 µM 1.28535404338331 0.117924261121456 no 522 0.0993342964161854 597 6458208
SGTC_143 4032-1194 15.74 µM 1.28417417333035 0.118140697330546 no 523 0.0995405098428562 654 1806963
SGTC_130 0136-0219 337.655 µM 1.28388182018979 0.118194370202381 no 524 0.0995916545995077 576 234244
SGTC_1372 2752-0194 270 µM 1.28316081180913 0.118326813230152 no 525 0.0997178711084669 515 823334
SGTC_1332 1480-0653 17.5 µM 1.28315554504451 0.118327781075288 no 526 0.0997187935145276 560 5749438
SGTC_3013 9080133 71.4286 µM 1.28229471270343 0.118486046845701 no 527 0.0998696410108392 609 17050193
SGTC_1279 0874-0590 65.2 µM 1.27992494875066 0.11892250539712 no 528 0.100285766157704 569 3523074
SGTC_625 k213-0058 121 µM 1.27848777093715 0.119187754478947 no 529 0.100538746979795 765 3655420
SGTC_841 0251-0215 91.2 µM 1.27444915175788 0.119935366762849 no 530 0.101252141187302 624 3888614
SGTC_2473 5854593 8.94 µM 1.27427875865014 0.119966981737883 no 531 0.101282320838274 528 2872951
SGTC_3252 9135871 49.47 µM 1.27092722366939 0.12059002463003 no 532 0.101877270198632 557 17682838
SGTC_283 0987-0079 11.7 µM 1.27033140080706 0.120701024858776 no 533 0.101983303739078 605 411556
SGTC_729 4092-0585 94.1 µM 1.27020936667868 0.120723768366835 no 534 0.102005031022899 526 2169061
SGTC_338 4055-0136 114 µM 1.26697500449758 0.121327656445039 no 535 0.102582113784921 569 2900563
SGTC_2059 5238311 157 µM 1.26687108629856 0.121347094179128 no 536 0.10260069439387 566 703021
SGTC_1724 st037281 8.293 µM 1.26281600146522 0.12210730175324 no 537 0.103327656366945 593 574124 YDL195W SEC31
SGTC_1527 coumarin 137 µM 1.26259235036403 0.122149326760747 no 538 0.103367859213528 520 323 A hepatotoxic, DNA x-linker.
SGTC_2407 paclitaxel 400 µM 1.26220279518436 0.12222255010785 no 539 0.103437911588624 598 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3017 9080681 49.47 µM 1.25396722013534 0.123777778884441 no 540 0.1049269601425 568 16451914
SGTC_3044 9093193 49.47 µM 1.25256496882521 0.124043958091131 no 541 0.105182035204967 587 25236277
SGTC_358 0075-0058 9.45 µM 1.25199907689662 0.124151490609245 no 542 0.10528510016435 672 1069125
SGTC_3311 9131146 2.8755 µM 1.25172418069964 0.124203750754924 no 543 0.105335192913028 595 4900406 YPR165W RHO1
SGTC_685 1278-0033 54.9 µM 1.25071029066092 0.124396633061932 no 544 0.105520097314141 605 3590572
SGTC_2659 sanguinarine 24.21 µM 1.24994800121383 0.124541788781575 no 545 0.105659271506255 582 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.2477343348281 0.124963987848311 no 546 0.106064181525431 574 6312947
SGTC_1202 1988-0068 29.6 µM 1.24701278720671 0.125101820032441 no 547 0.106196404468143 603 2850480
SGTC_1403 3909-7815 62.9 µM 1.24497693438012 0.125491287007164 no 548 0.106570114453036 527 6615483
SGTC_697 0508-1955 564 µM 1.24435111726469 0.125611178241564 no 549 0.106685182698103 639 6243113
SGTC_1472 k841-0093 193 µM 1.24305196481884 0.125860319142563 no 550 0.106924342536846 629 X1472
SGTC_2748 diazoxide 86.69 µM 1.24029557319681 0.126390058304846 no 551 0.107433044588012 526 3019 A potassium channel activatior.
SGTC_1010 4112-3296 15.2 µM 1.23988177583061 0.126469718177443 no 552 0.107509562733658 637 704384
SGTC_2261 9010538 184.68 µM 1.23766025954443 0.12689797881803 no 553 0.107921030223555 507 6457250
SGTC_98 0074-0023 107.663 µM 1.2369327590655 0.127038444468124 no 554 0.10805602347797 622 3563821
SGTC_107 0358-0022 2.6945 µM 1.23622157114825 0.127175865052682 no 555 0.108188107285959 431 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1385 3091-4834 14.1 µM 1.22859379495511 0.128656260998035 no 556 0.109612071558388 551 4072814
SGTC_3314 9135860 59.4275 µM 1.22665806158381 0.129033842147304 no 557 0.109975568314538 622 25252478
SGTC_2878 9043973 25.97 µM 1.22607058029772 0.129148587172978 no 558 0.110086057886184 563 6465167
SGTC_2730 imipramine 71.33 µM 1.22403181560791 0.129547341013735 no 559 0.110470112856393 700 3696 A tricyclic antidepressant.
SGTC_230 MPP+ 141.667 µM 1.22127479213204 0.130087931588164 no 560 0.110990997184853 575 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_154 3389-1638 511.116 µM 1.21946923677516 0.13044280543921 no 561 0.111333072559613 525 5238686
SGTC_1123 mangostin 811.285 nM 1.21796257162376 0.130739445787424 no 562 0.111619098144245 595 5281650 An antioxidant.
SGTC_2980 9014342 25.29 µM 1.21062230075229 0.132191305888281 no 563 0.113020096672936 593 2996599
SGTC_2647 atorvastatin 60.16 µM 1.20855299251837 0.132602603112913 no 564 0.113417312610391 587 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1839 st053978 48 µM 1.20686222971876 0.132939314150591 no 565 0.113742602824784 609 3788398
SGTC_262 fenpropimorph 62.5 µM 1.20446257511807 0.133418208986679 no 566 0.114205419372776 556 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_5 0352-0601 109.883 µM 1.20271283354806 0.133768149059975 no 567 0.114543732955442 563 762456
SGTC_2924 9010168 62.78 µM 1.20221022886685 0.133868784173239 no 568 0.114641043615663 633 2993929
SGTC_1399 3562-5772 25 µM 1.20005923220807 0.134300059943539 no 569 0.115058168561668 529 23847490
SGTC_542 3381-0244 89.3 µM 1.19746797445859 0.134820874125706 no 570 0.1155621014772 693 1112843
SGTC_2219 9098279 200 µM 1.19626093189079 0.135063948808804 no 571 0.115797374754659 593 902349
SGTC_2017 5132927 60.65 µM 1.19610744815868 0.135094878944375 no 572 0.115827315723583 618 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3006 9075424 71.4286 µM 1.19396785463809 0.135526556965236 no 573 0.116245271321018 582 7465181
SGTC_1630 st005209 31.3 µM 1.19144299370606 0.136037179939276 no 574 0.116739861613744 714 3367314
SGTC_2888 9058547 12.99 µM 1.1903353802764 0.136261596592656 no 575 0.116957300075612 526 16476514
SGTC_2845 9003024 42.97 µM 1.19009334893736 0.13631066894527 no 576 0.117004852062287 642 2990173
SGTC_1201 1889-3372 45.9 µM 1.18291695830203 0.13777119295517 no 577 0.118421030017149 605 5392199
SGTC_2026 5148700 152 µM 1.18097387495573 0.138168475490427 no 578 0.118806550910441 623 79838
SGTC_2998 9066762 71.4286 µM 1.18016655821458 0.138333768823676 no 579 0.118966988423935 681 4945196
SGTC_2681 menadione 3.18 µM 1.17708828163263 0.13896526424252 no 580 0.119580135901923 631 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1162 k048-0130 20.1 µM 1.17426676368057 0.139545808141792 no 581 0.120144095759763 640 6797406
SGTC_2988 9073640 71.4286 µM 1.17422285751614 0.139554855107198 no 582 0.120152886428246 598 9102229
SGTC_155 k072-0202 43.6 µM 1.17274499895134 0.139859603924722 no 583 0.120449040146954 616 5857737
SGTC_2978 9011784 42.97 µM 1.16970576492388 0.140487744280988 no 584 0.121059698694048 757 2994934
SGTC_652 0437-0092 114 µM 1.1679915052768 0.140842886189446 no 585 0.12140509570765 616 3091274
SGTC_3122 9126309 49.47 µM 1.16580063232801 0.141297653670424 no 586 0.121847530756571 623 17591206
SGTC_2616 abietic acid 100 µM 1.16430905952116 0.141607833779141 no 587 0.122149393227747 701 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1414 3917-0015 5.4 µM 1.16367346708297 0.141740148503967 no 588 0.122278182971301 617 6618702
SGTC_2072 5231554 129 µM 1.16328609513811 0.141820830878795 no 589 0.122356722668815 660 789545
SGTC_2398 5228213 48.84 µM 1.16218908221787 0.142049487005082 no 590 0.122579334229522 745 80771 YMR134W ERG29
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.16189163980093 0.142111527460321 no 591 0.122639741726387 666 5282309
SGTC_1939 st074455 53.6 µM 1.16181087316474 0.142128376908055 no 592 0.1226561482044 654 1644229
SGTC_1642 st009582 77.7 µM 1.1611643933942 0.14226329353852 no 593 0.122787525935653 611 6739311
SGTC_2907 7721985 69.9 µM 1.16076168055074 0.142347381196188 no 594 0.12286941517899 628 3267881
SGTC_1722 st034304 3.6505 µM 1.15873994794688 0.142770033136659 no 595 0.123281101086184 653 4036148 YLR033W RSC58
SGTC_99 0109-0120 622.8 µM 1.15500145096832 0.14355381479943 no 596 0.12404491614362 596 759414
SGTC_3119 9125183 49.47 µM 1.15441446893726 0.143677139796433 no 597 0.124165143001821 512 22695334
SGTC_1425 4048-4433 7.33 µM 1.15419708497391 0.143722830330811 no 598 0.124209688707699 703 23734946
SGTC_1873 rapamycin 2 nM 1.15148523581976 0.144293640490048 no 599 0.124766332888945 700 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_575 k072-0246 11.9 µM 1.14685674050299 0.145271406048712 no 600 0.125720417045169 679 6796779
SGTC_416 estradiol valerate 100 µM 1.14666806877039 0.145311357121954 no 601 0.125759416126934 647 13791 A steroid.
SGTC_1883 5-benzylidenerhodanine 20 µM 1.14541188656866 0.145577541025518 no 602 0.126019288353457 726 1273210
SGTC_576 1073-0113 22.7 µM 1.14324882501186 0.146036659796478 no 603 0.126467647882198 848 5439563
SGTC_664 1222-0054 14.9 µM 1.14253661464037 0.146188042048263 no 604 0.126615517795355 683 6813991
SGTC_857 0438-0306 1.35 µM 1.14214747478231 0.146270799293734 no 605 0.126696362299395 665 4686136
SGTC_1980 st071811 45.7 µM 1.14147661585733 0.146413542772926 no 606 0.12683581883333 654 4974850
SGTC_958 1222-0007 33 µM 1.13586132352023 0.147612015811941 no 607 0.128007303623406 723 7312461
SGTC_1413 3910-0535 34.4 µM 1.13535857827926 0.147719636422965 no 608 0.128112553789661 707 2876951
SGTC_2168 5727979 200 µM 1.13253545491336 0.148324946690572 no 609 0.128704693598792 607 695210
SGTC_3102 9121669 49.47 µM 1.1324871511547 0.148335317990983 no 610 0.128714841632037 629 41905072
SGTC_1911 st060208 74.3 µM 1.13149651273887 0.148548124960284 no 611 0.128923085185389 710 688783
SGTC_2617 dihydrotanshinone i 20.83 µM 1.13049582176111 0.148763298553674 no 612 0.129133679021575 710 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1273 0849-0096 14.1 µM 1.12368363737188 0.150233622617322 no 613 0.13057363017385 697 5286025
SGTC_630 4356-0227 183 µM 1.12342906582208 0.150288755766715 no 614 0.130627655555413 659 779312
SGTC_2095 5432005 200 µM 1.12227029194996 0.150539884458194 no 615 0.130873766763452 644 783734
SGTC_140 0062-0056 502.533 µM 1.12110716432023 0.150792237623625 no 616 0.131121124735812 726 3758964
SGTC_2906 7926292 26.41 µM 1.1187702237964 0.151300113166887 no 617 0.131619088877531 689 2966319
SGTC_2005 4024620 188 µM 1.11824342137875 0.151414757448141 no 618 0.13173152196569 685 236743
SGTC_1515 3460-0031 42.1 µM 1.11719665805505 0.151642728524162 no 619 0.131955124610169 602 2876596
SGTC_105 0111-0055 734.78 µM 1.11666471082089 0.151758666911607 no 620 0.13206885591524 596 5179370
SGTC_1038 k292-0204 154 µM 1.11544556212157 0.1520246036352 no 621 0.132329767098373 652 4454212
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.11029064051267 0.153152482324532 no 622 0.133436902473036 677 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2552 juarezic acid 87.02 µM 1.10982912122561 0.153253730905534 no 623 0.133536333961066 816 1549512
SGTC_1849 st056239 19.2 µM 1.10661628301945 0.153959795528428 no 624 0.134229932131735 697 5393181
SGTC_61 0978-8327 98.565 µM 1.10192648778001 0.154994299709708 no 625 0.13524681602446 740 6150059 YHR072W ERG7
SGTC_1741 st038134 10.228 µM 1.1004600942353 0.155318705798676 no 626 0.135565853778865 742 1272587
SGTC_506 n9-isopropylolomoucine 153 µM 1.09635472679176 0.156229306365836 no 627 0.13646178416971 713 6610355
SGTC_759 3486-0358 89.3 µM 1.09605464667323 0.156296003991465 no 628 0.136527430297128 772 875103
SGTC_2953 9074162 66.49 µM 1.09535865165313 0.156450772253772 no 629 0.136679770690268 652 16451992
SGTC_1606 st000094 49.2 µM 1.09357881342723 0.156847013372369 no 630 0.137069872729707 762 1242210
SGTC_790 1575-0012 79.1 µM 1.09305984429803 0.156962674461081 no 631 0.137183762641027 746 378741 YLR208W SEC13
SGTC_1665 st014639 11.4 µM 1.09166765732664 0.157273224061381 no 632 0.137489603026806 761 981133 YIL048W NEO1
SGTC_2443 5493264 126.67 µM 1.09155528474064 0.157298308173207 no 633 0.137514309707387 710 5340055
SGTC_876 0720-0963 56.8 µM 1.08818790437786 0.158051204181383 no 634 0.138256081686277 757 765861
SGTC_735 3076-0345 636 µM 1.08702586823924 0.158311566256331 no 635 0.138512688792302 775 2888990
SGTC_3338 9144300 39.5675 µM 1.08657787624535 0.158412017015384 no 636 0.138611703428048 726 4901274
SGTC_22 0964-0034 14.468 µM 1.08453354483563 0.158870936723808 no 637 0.139064151036284 748 138402
SGTC_276 colchicine 750 µM 1.08269518975936 0.159284361381975 no 638 0.139471869914646 734 2833 A microtubule depolymerizer.
SGTC_1208 2323-2347 50.3 µM 1.08122556725946 0.159615368658768 no 639 0.139798393830703 748 5412760
SGTC_2646 retinol 96.75 µM 1.08084384254291 0.159701419204914 no 640 0.139883291204737 702 445354 A vitamin A analog and teratogen.
SGTC_2802 7925815 54.55 µM 1.07637695242161 0.160710626327142 no 641 0.140879352832604 726 1262923
SGTC_2074 5212007 75.395 µM 1.07418764119188 0.161206776227431 no 642 0.141369295194526 670 758611
SGTC_120 rhodamine 6G 52.259 µM 1.07196587998627 0.161711300581551 no 643 0.141867678827153 872 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1691 st019933 84.6 µM 1.06677786482949 0.162893413697649 no 644 0.143036078153532 728 6176082
SGTC_3004 9076122 71.4286 µM 1.06466518724113 0.163376402859564 no 645 0.143513734592772 744 44782551
SGTC_1636 st007707 68.9 µM 1.06436330426795 0.16344549363024 no 646 0.143582075301268 777 403051
SGTC_583 1488-1091 88.9 µM 1.06361704956178 0.163616367440491 no 647 0.143751107782429 864 4303273
SGTC_302 1094-0063 18.9 µM 1.06329778313504 0.163689506943198 no 648 0.143823465099109 670 5440289
SGTC_1097 itavastatin 7.23 µM 1.05948600957187 0.164564370419954 no 649 0.144689248728313 764 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_596 1155-0152 116 µM 1.0536381959278 0.165912417003154 no 650 0.146024297400009 790 280313
SGTC_3140 9094243 49.47 µM 1.05361570637868 0.16591761506525 no 651 0.146029447660574 782 19291112
SGTC_708 3448-5400 146 µM 1.05336895016876 0.16597465531814 no 652 0.146085964535738 757 3462195
SGTC_1398 3558-0053 112 µM 1.04852055979343 0.167097981075534 no 653 0.147199417425548 684 4532369
SGTC_1966 st070145 16.1 µM 1.04347673882195 0.168271776153445 no 654 0.148363774309312 738 3748532
SGTC_3080 9117754 49.47 µM 1.04329166195979 0.168314947773211 no 655 0.148406615814583 828 9550191
SGTC_293 4049-0273 38.5 µM 1.04283143053768 0.168422333705287 no 656 0.148513185833897 713 1380311
SGTC_744 1594-0068 283 µM 1.04196975025041 0.1686235082539 no 657 0.148712851895579 810 668392
SGTC_2411 st077133 39.94 µM 1.03748469065746 0.169673117998086 no 658 0.149755013446753 816 1403142 YNL221C POP1
SGTC_2543 pimpinellin 60.67 µM 1.03582466838809 0.17006266266636 no 659 0.150141973439441 744 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2452 5863136 48.41 µM 1.03550493431618 0.170137757985983 no 660 0.150216581630563 747 2184096
SGTC_1360 1598-0022 39.8 µM 1.03454941902618 0.170362304624067 no 661 0.150439693121735 847 761525
SGTC_2972 9093619 59.92 µM 1.0339199246752 0.170510339829514 no 662 0.150586799747523 749 25236256
SGTC_3180 9109287 49.47 µM 1.03391392803133 0.170511750427808 no 663 0.150588201564618 717 18891271
SGTC_1338 1486-1223 76 µM 1.03233239910493 0.170884036374339 no 664 0.150958214169135 808 3444526
SGTC_2353 9059630 146.67 µM 1.03225758793791 0.170901659514289 no 665 0.150975731875392 770 4779114
SGTC_1931 st074438 57.1 µM 1.02977126280251 0.171488020382964 no 666 0.151558696881339 736 2787313
SGTC_1865 st057639 52.2 µM 1.02952493627988 0.171546182553442 no 667 0.151616534062763 768 688818
SGTC_1054 3429-0080 167 µM 1.02389280207077 0.172879469737768 no 668 0.152942955192792 798 1162877
SGTC_273 hydroxyurea 18.1 mM 1.0119233537683 0.175734842830526 no 669 0.155787351024057 864 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2293 7624732 200 µM 1.00970117005643 0.176268226099059 no 670 0.156319240865128 723 894453
SGTC_712 r015-0009 80.6 µM 1.00843762020283 0.176571968098775 no 671 0.156622210119218 746 6813872 YLR060W FRS1
SGTC_2908 7930301 100 µM 1.00684766122065 0.176954644892543 no 672 0.157003993400158 865 2223178
SGTC_2911 7942208 15.64 µM 1.00599002141497 0.177161282017636 no 673 0.157210185081798 744 1243384
SGTC_3258 9138477 49.47 µM 1.00503709766197 0.177391055245967 no 674 0.15743949343105 791 4970355
SGTC_2959 9079155 11 µM 1.00281990840376 0.177926401586891 no 675 0.157973880712143 736 16189457
SGTC_1082 camptothecin 424.86 nM 1.00276065670622 0.177940722033352 no 676 0.157988177883657 702 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1124 fisetin 1.16336 µM 1.00138492944706 0.178273423656231 no 677 0.158320373603172 738 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3146 9095609 49.47 µM 1.00036052434666 0.178521417078473 no 678 0.158568033319501 794 17173999
SGTC_878 0828-0289 13.7 µM 0.999989457381251 0.178611300521772 no 679 0.158657804950001 807 745350 YLR208W SEC13
SGTC_2767 sibutramine 71.45 µM 0.999311694226301 0.178775548445963 no 680 0.158821861096816 831 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_296 1222-0039 74.9 µM 0.998827552823143 0.17889293261682 no 681 0.15893911813466 754 5984176
SGTC_1697 st025554 27.742 µM 0.99846618636892 0.178980580573511 no 682 0.159026676555194 767 1269519
SGTC_580 1123-0028 41 µM 0.997879737600921 0.179122878825063 no 683 0.159168839251151 894 1677248 YPR107C YTH1
SGTC_2885 9057732 51.95 µM 0.997062571814209 0.179321277806909 no 684 0.159367069476598 781 6471414
SGTC_213 1246-0773 967 nM 0.995311728048903 0.179746828653755 no 685 0.15979233772788 828 6251622
SGTC_3078 9116413 49.47 µM 0.992463193898702 0.180440532871751 no 686 0.160485812684705 761 17177322
SGTC_1704 st028805 70.8 µM 0.991995953523374 0.180554480165634 no 687 0.160599749671796 789 2876101
SGTC_2945 9067681 61.76 µM 0.986441119540799 0.181912609787071 no 688 0.161958347717392 787 16456930
SGTC_126 0417-1624 672.48 µM 0.9862397771204 0.181961956706373 no 689 0.162007732126507 978 41912 YDL195W SEC31
SGTC_1884 5633444 25 µM 0.985610583235481 0.182116219485814 no 690 0.162162121326699 831 5724239
SGTC_297 0986-0032 24 µM 0.983109452991911 0.182730242837017 no 691 0.162776786165808 784 2847425
SGTC_763 3453-1109 128 µM 0.981517419152917 0.183121756893828 no 692 0.163168824349167 862 1560353
SGTC_1670 st016595 4.04 µM 0.977168565010113 0.184193894475637 no 693 0.164242853868863 846 597879
SGTC_700 3453-2283 142 µM 0.976988530406191 0.184238363061575 no 694 0.164287415326147 875 565664
SGTC_2912 7964298 10.93 µM 0.97655694885066 0.184344991000762 no 695 0.164394270614243 865 2975850
SGTC_3232 9132874 49.47 µM 0.975855317158496 0.184518420332723 no 696 0.16456808376397 802 3784940
SGTC_1063 disulfiram 1.84 µM 0.975781837517213 0.184536588899915 no 697 0.164586293545517 803 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2716 st080858 38.6235 µM 0.974608854517907 0.184826771160719 no 698 0.16487715988226 870 5296050
SGTC_648 0375-0473 33.3 µM 0.97269106215928 0.185301821067598 no 699 0.165353434363074 854 1713139
SGTC_341 1486-1430 230 µM 0.971361199417854 0.185631681620898 no 700 0.165684221499858 804 2054753 YPL210C SRP72
SGTC_2176 5809774 33.9695 µM 0.970777511221839 0.185776575233022 no 701 0.165829541840129 870 2870539
SGTC_1861 st057647 17.4 µM 0.969098531245988 0.186193752904033 no 702 0.166248015231976 837 688668
SGTC_1539 benzyladenosine 56 µM 0.968504478667407 0.186341496625143 no 703 0.166396241674193 809 92208 A nucleotide analog.
SGTC_1728 st035614 33.7865 µM 0.965834502761463 0.187006428828382 no 704 0.167063500331688 889 15945546
SGTC_3187 9109394 49.47 µM 0.965064247616665 0.187198526058549 no 705 0.167256316460421 824 17098090
SGTC_702 1488-0190 94 µM 0.964199488678007 0.18741433733933 no 706 0.167472960346727 845 949357
SGTC_2828 7998861 71.43 µM 0.963966524048455 0.187472502826726 no 707 0.167531354751853 772 2988188
SGTC_937 3122-0005 46.7 µM 0.961373338876651 0.188120709883341 no 708 0.168182242334358 887 759535
SGTC_1635 st007035 42.4 µM 0.96085182418423 0.188251237479699 no 709 0.168313338378528 949 3716403
SGTC_2367 9070478 135.38 µM 0.955890618946021 0.189495748111799 no 710 0.169563749490497 834 572802
SGTC_673 1082-0474 110 µM 0.954481512296447 0.189850141407616 no 711 0.169919981578234 923 3098046
SGTC_321 4534-3890 65.3 µM 0.954233572389893 0.189912540952656 no 712 0.169982712137139 861 699746
SGTC_2846 9008642 19.48 µM 0.95318847691672 0.190175700834724 no 713 0.170247291862634 780 2992898
SGTC_2620 irigenin 100 µM 0.949683522906534 0.191059899049096 no 714 0.171136542266953 878 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1326 1431-2094 10.8 µM 0.94966004764193 0.191065829663841 no 715 0.171142508230129 835 616278
SGTC_2283 7944793 200 µM 0.949362886650005 0.191140911946602 no 716 0.171218039708815 855 2970533
SGTC_2985 9022375 71.43 µM 0.949163666550385 0.191191258088746 no 717 0.171268688801862 846 4939335
SGTC_2087 5276107 200 µM 0.944344128023564 0.192411709656154 no 718 0.172496911394441 849 144405
SGTC_23 0213-0011 39.996 µM 0.943486902201898 0.192629282844718 no 719 0.172715955827526 853 627608
SGTC_1111 tnp00062 510.699 nM 0.942273280365669 0.192937570201582 no 720 0.173026372173377 902 676306
SGTC_2073 5212005 126 µM 0.938539778405852 0.193887851813166 no 721 0.173983542269718 770 691789
SGTC_502 l-744,832 89.3 µM 0.937390039021387 0.194181066461133 no 722 0.17427898143602 884 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1965 Pectolinarigenin 58.4 µM 0.932314363879843 0.195478725814154 no 723 0.175587043316438 878 5320438 An anti-inflammatory.
SGTC_2323 6148992 148.28 µM 0.93214075024536 0.195523205250483 no 724 0.175631895384423 780 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1502 4534-4282 27.7 µM 0.929243783686573 0.196266308403479 no 725 0.176381380775967 851 3278949
SGTC_1358 1509-0022 2.48 µM 0.928374664161956 0.196489580404035 no 726 0.176606628058855 902 3258434
SGTC_2819 7996655 46.38 µM 0.925115690920254 0.197328162304317 no 727 0.177452865988267 776 6456960
SGTC_642 0335-0876 158 µM 0.92434763775297 0.197526108461347 no 728 0.177652673826673 886 6812350
SGTC_1475 4092-1048 11.7 µM 0.923316551869244 0.197792033285487 no 729 0.177921132335509 900 2881759
SGTC_2934 9036370 36.88 µM 0.920427993507348 0.198538165292267 no 730 0.17867457279093 915 6462800
SGTC_2587 piperic acid 92.2 µM 0.919707495887233 0.198724538389971 no 731 0.17886281721537 804 5370536
SGTC_1052 3253-3998 198 µM 0.914954451199012 0.19995666278731 no 732 0.180107771312894 935 5450317
SGTC_409 arachidonic acid 100 µM 0.914190976906114 0.2001550043577 no 733 0.180308252275411 887 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2862 9027634 71.43 µM 0.912770204735347 0.200524418749004 no 734 0.180681705903941 811 5012562
SGTC_419 nsc-638432 893 µM 0.912249176806041 0.200659993550654 no 735 0.180818780893409 890 368090
SGTC_955 1216-0110 33 µM 0.909236730747612 0.201444929560216 no 736 0.18161258976001 877 3619719
SGTC_1107 amlodipine 47 µM 0.90909196151061 0.201482697542201 no 737 0.181650792703534 860 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2957 9076800 11.52 µM 0.908764802619248 0.201568063700015 no 738 0.181737144708497 806 16459615
SGTC_1037 k284-1091 78.7 µM 0.905601748942074 0.202394521959775 no 739 0.182573341380134 844 3334711
SGTC_43 0570-0105 72.5 µM 0.904630491594708 0.202648702941735 no 740 0.182830588024561 957 1114046 YDL195W SEC31
SGTC_290 2043-6722 48.1 µM 0.90449630857671 0.202683834035959 no 741 0.182866145437938 903 773758 YLR208W SEC13
SGTC_981 1488-1094 54.9 µM 0.904436746607742 0.202699429404648 no 742 0.182881930260529 850 3449522
SGTC_2831 7999036 19.48 µM 0.902282172506375 0.203264052888382 no 743 0.183453496639322 946 2988270
SGTC_1147 3809-1045 12.3 µM 0.901072166452407 0.203581555890603 no 744 0.183774975322839 879 325925
SGTC_96 0929-0093 37.281 µM 0.898045827679925 0.204376954602854 no 745 0.184580558969289 877 6991579
SGTC_913 3487-1245 167 µM 0.89648434387055 0.204788074711691 no 746 0.184997069163811 869 4016153
SGTC_3212 9128307 49.47 µM 0.894762059456918 0.20524210166248 no 747 0.185457147982013 786 27243542
SGTC_110 0850-0284 111.64 µM 0.89437866839803 0.205343252164037 no 748 0.185559660908974 786 3906265
SGTC_2242 6630449 61.2675 µM 0.889391196864687 0.206661798490471 no 749 0.186896437200462 818 691249 YDR170C SEC7
SGTC_792 4534-1957 155 µM 0.887586546126306 0.207140129640082 no 750 0.187381596629281 928 1717904
SGTC_1795 st049545 62.3 µM 0.884394699221542 0.207987745325577 no 751 0.188241591718516 939 5291882
SGTC_3183 9108214 49.47 µM 0.878939485716543 0.209441143868563 no 752 0.189717043916288 861 4974831
SGTC_1751 st044839 27.194 µM 0.877709297644276 0.209769719020745 no 753 0.190050748768013 940 5291326
SGTC_1257 0669-0121 16 µM 0.876325913383821 0.210139573645722 no 754 0.19042644076354 1026 4307855
SGTC_3178 9107506 49.47 µM 0.875713371217413 0.210303462104311 no 755 0.190592937222132 922 8897194
SGTC_2190 6049624 200 µM 0.873456498752352 0.210907945988973 no 756 0.191207153605193 893 2265554
SGTC_443 clozapine 122 µM 0.870515604605509 0.211697165992031 no 757 0.192009347617284 868 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1850 st056238 17 µM 0.870322198465569 0.21174912907473 no 758 0.192062175506928 1029 5393177
SGTC_3199 9111318 49.47 µM 0.868155332419696 0.212331818393389 no 759 0.192654651638219 918 8548020
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.867607843292399 0.212479191182612 no 760 0.192804525623235 1016 368090
SGTC_1238 0333-0287 48.8 µM 0.866477351900822 0.212783685176232 no 761 0.193114220547467 941 7226
SGTC_275 trichlorophene 5.69 µM 0.866458805081475 0.212788682821564 no 762 0.193119303927046 1035 62616
SGTC_3289 9119912 71.43 µM 0.865476884233624 0.213053370070783 no 763 0.193388548996806 927 17014829
SGTC_207 4185-0010 4.486 µM 0.863640863865117 0.213548803993682 no 764 0.193892604341556 1031 3761753
SGTC_1605 st000082 49.1 µM 0.863008000100387 0.213719732165441 no 765 0.194066534199469 967 1114022
SGTC_70 0141-0289 43.283 µM 0.860834598442141 0.214307345778801 no 766 0.194664573251805 1074 352408
SGTC_2055 5235184 200 µM 0.858220662180018 0.215015308173781 no 767 0.19538531438151 935 2836034
SGTC_616 4092-0450 108 µM 0.858122824590961 0.215041832992701 no 768 0.195412322592905 981 787165
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.854225182132308 0.216100070209834 no 769 0.196490116429899 1000 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_946 3434-1334 87.4 µM 0.854103426632661 0.216133176189281 no 770 0.196523842733991 942 4047976
SGTC_2513 baicalein 25.65 µM 0.851466310760877 0.216850942707492 no 771 0.197255184949861 975 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.850529215542927 0.217106331454792 no 772 0.197515462290521 998 4174840
SGTC_2389 9091542 195.52 µM 0.848395263819216 0.217688550311048 no 773 0.198108939714663 947 3626624 YOL127W RPL25
SGTC_67 0335-0847 266 µM 0.848201836308765 0.217741368791261 no 774 0.198162787381233 1048 4552207 YOR254C SEC63
SGTC_1681 tripelennamine 100 µM 0.847189588642996 0.218017899786375 no 775 0.198444727863601 934 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_815 1582-0027 36.9 µM 0.846924883167136 0.218090246763812 no 776 0.198518495955689 982 3128206
SGTC_1629 st005085 44.9 µM 0.846431742374549 0.218225064574918 no 777 0.198655968483291 956 24207091
SGTC_3111 9122088 49.47 µM 0.845812502644838 0.2183944240692 no 778 0.198828674810649 883 16876704
SGTC_2207 7258803 200 µM 0.8457597847388 0.218408845693588 no 779 0.198843382045467 947 3666799
SGTC_2588 indole-3-carbinol 100 µM 0.842696834802769 0.219247694164526 no 780 0.19969900892861 998 3712 Induces cell cycle arrest.
SGTC_2099 5377090 177.372 µM 0.841722725299421 0.219514860640597 no 781 0.199971587394876 943 2243829
SGTC_361 000s-0510 1.45 µM 0.841584991444224 0.219552651630864 no 782 0.200010146570691 956 660
SGTC_1848 st056003 16.4 µM 0.838210702003513 0.220479645232087 no 783 0.200956188769462 1074 146492
SGTC_789 1309-1135 70.6 µM 0.837328735456974 0.220722310621545 no 784 0.201203905662192 1024 3092424
SGTC_1648 st011736 69.8 µM 0.832054029120891 0.222176789269091 no 785 0.202689224225943 987 2855514
SGTC_2994 9053520 71.4286 µM 0.831305107564802 0.222383743851577 no 786 0.202900644982312 997 4647384
SGTC_1895 st058434 18.3 µM 0.830069382502636 0.222725460441236 no 787 0.203249778342189 1040 5393175
SGTC_872 0588-0139 234 µM 0.829563964432301 0.222865310513447 no 788 0.203392678981182 1042 2047100
SGTC_166 k072-0058 166.424 µM 0.829552916224488 0.22286836813071 no 789 0.203395803393133 1069 5846229
SGTC_1757 st041620 31.8375 µM 0.828534082778948 0.223150435366093 no 790 0.203684050597992 1009 5289815
SGTC_2162 5663267 200 µM 0.826927782733198 0.223595557128354 no 791 0.204138997580168 1033 6456493
SGTC_2653 dihydrofissinolide 100 µM 0.826383271150456 0.223746561237611 no 792 0.204293355027152 1023 6857746
SGTC_2964 9083345 53.42 µM 0.826347329514918 0.223756530621603 no 793 0.204303546160369 954 17741579
SGTC_3296 9122258 64.045 µM 0.82601786702576 0.22384792771287 no 794 0.204396978275224 984 4730474
SGTC_2601 securinine 100 µM 0.82570991296932 0.223933377273052 no 795 0.204484333817845 961 442872 A GABA receptor antagonist.
SGTC_518 1021-0119 62.6 µM 0.824959358020453 0.224141715145546 no 796 0.204697332439328 915 1097762
SGTC_885 0865-0106 16.8 µM 0.823320500310551 0.224597009109049 no 797 0.205162879355964 1035 2793380
SGTC_2856 9022925 19.48 µM 0.820717288987195 0.225321289289534 no 798 0.205903660278059 992 4944862
SGTC_1570 verbenone 133 µM 0.820474898210019 0.225388795866366 no 799 0.205972716687387 1019 29025 A natural terpanoid with antifungal properties.
SGTC_2571 chrysanthemic acid 100 µM 0.818335032576788 0.225985251564566 no 800 0.206582953728263 951 2743 An insecticide.
SGTC_2727 riluzole 51.77 µM 0.816067322212767 0.226618314839467 no 801 0.207230816216735 1011 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2135 5326629 150.42 µM 0.81566437892792 0.226730906772369 no 802 0.207346058732556 964 5020077
SGTC_812 4251-0442 148 µM 0.813711460324787 0.227277045665197 no 803 0.207905133637511 1027 5723007
SGTC_340 k038-0059 454 µM 0.813693834842542 0.227281978051332 no 804 0.20791018345033 1028 23733424
SGTC_2804 7954240 19.48 µM 0.812470423211248 0.227624489870016 no 805 0.208260875618711 1025 828705
SGTC_3144 9087057 49.47 µM 0.812086270570609 0.227732098891673 no 806 0.208371065314042 977 17249618
SGTC_1976 st070609 63.5 µM 0.809467217156574 0.2284665120037 no 807 0.209123226123754 1018 682556
SGTC_1096 rimcazole 32.2 µM 0.807535976747604 0.229008905577229 no 808 0.209678877886063 959 18528119 A dopamine reuptake inhibitor.
SGTC_2267 7931562 200 µM 0.80608691847832 0.229416351075557 no 809 0.210096366902168 929 934880
SGTC_1045 1348-1485 165 µM 0.805859826937519 0.229480241370057 no 810 0.210161838611249 1130 6810614
SGTC_1782 st039423 80.636 µM 0.805298158219601 0.229638304958225 no 811 0.210323822181475 966 2068169
SGTC_1518 st038567 90.8 µM 0.805113559599996 0.229690267612532 no 812 0.210377075870144 1044 77966
SGTC_740 k014-0057 261 µM 0.803917691868656 0.230027051821282 no 813 0.210722255892759 1062 4012779
SGTC_1863 st057641 20.1 µM 0.802983999637169 0.23029019329359 no 814 0.210991991349938 1082 3921635
SGTC_846 0335-0850 148 µM 0.802125457339649 0.230532303831215 no 815 0.211240195193396 1027 6819598
SGTC_2030 5175110 200 µM 0.800080088868714 0.231109674339738 no 816 0.211832198257928 1060 2831986
SGTC_2254 7938975 95.19 µM 0.799735538588431 0.231207014006355 no 817 0.21193201892443 1072 2969277
SGTC_725 1497-0963 19 µM 0.799707395450872 0.23121496579714 no 818 0.211940173570201 1070 3549977
SGTC_1862 st057513 3.81 µM 0.798869461501179 0.231451792354071 no 819 0.212183054115338 1063 5393163
SGTC_810 3825-7150 143 µM 0.798538789067149 0.231545288016919 no 820 0.212278946405621 1091 22330411 YGL099W LSG1
SGTC_1594 piperine 70.1 µM 0.798338897893082 0.231601816265272 no 821 0.212336925485955 1021 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1825 st052143 62.6 µM 0.798174079895699 0.231648431775697 no 822 0.212384738438392 1008 674173
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.797614342394469 0.231806781481682 no 823 0.212547162698585 1096 16486 A toxic proline analog.
SGTC_3114 9122766 49.47 µM 0.795805526822465 0.232318907354533 no 824 0.213072539429003 956 17176985
SGTC_3351 9150312 21.596 µM 0.794513223882759 0.232685179336982 no 825 0.213448356817084 1033 4904905
SGTC_1816 st051957 91.6 µM 0.793370740398676 0.233009255745669 no 826 0.21378092642254 1049 674121
SGTC_1893 st059353 36.1 µM 0.793348477076069 0.233015573439792 no 827 0.213787410128996 1008 3112488
SGTC_303 1348-1668 34.2 µM 0.792070569816378 0.233378366362822 no 828 0.214159764612349 1034 5380509
SGTC_1447 4239-0816 81.9 µM 0.791711015336143 0.233480498951601 no 829 0.214264598980788 988 1341554
SGTC_2066 5222451 176 µM 0.790958802092789 0.233694247670303 no 830 0.21448401637843 1107 2281147
SGTC_3021 9087658 49.47 µM 0.78911891473195 0.234217526474678 no 831 0.215021253920367 1055 25237042
SGTC_1832 st054113 55 µM 0.78847997532663 0.234399397627817 no 832 0.215208003542505 1051 1251267
SGTC_1116 jasmonic acid 1.58368 µM 0.786459899253472 0.23497491674419 no 833 0.215799051642048 1060 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2358 9037157 4 µM 0.786152410538778 0.235062588610756 no 834 0.215889101290444 1046 2388925
SGTC_223 busulfan 5 mM 0.785391619461877 0.235279584699235 no 835 0.216111996424587 995 2478 A DNA alkylator.
SGTC_2201 6605497 169.863 µM 0.783332780336639 0.235867369841631 no 836 0.216715859176405 1059 670741
SGTC_1484 3473-2379 286 µM 0.782788318897057 0.236022945259692 no 837 0.216875714099248 1213 671917
SGTC_3153 9100258 49.47 µM 0.780387569586943 0.236709613692788 no 838 0.217581391148989 1002 25236848
SGTC_3213 9129884 49.47 µM 0.780138424485653 0.236780937689819 no 839 0.217654700762729 1034 17190742
SGTC_2531 methyl deoxycholate 70.07 µM 0.779303532165866 0.237020032569861 no 840 0.217900467241447 1052 16667744 Haematoxylin.
SGTC_633 0437-0093 97.7 µM 0.778000653635602 0.237393413404547 no 841 0.218284313938984 1107 2831118
SGTC_938 3126-1755 342 µM 0.77797867113918 0.237399715949691 no 842 0.218290793637791 1107 1777771
SGTC_2794 7785382 27.27 µM 0.77770240432342 0.237478931531388 no 843 0.218372237228086 1106 2205081
SGTC_3293 9120939 62.045 µM 0.777232027235375 0.237613838850723 no 844 0.218510944882877 1038 934087
SGTC_523 1934-0222 13.7 µM 0.776267616821032 0.237890569712675 no 845 0.218795494674698 1074 1361595
SGTC_1684 st024538 14.6195 µM 0.77387266168597 0.238578549141409 no 846 0.219503048912591 1065 6732859
SGTC_1454 4239-0054 42.6 µM 0.771910236383693 0.239143089982237 no 847 0.220083797066354 1123 1340767
SGTC_1260 0700-1617 7.75 µM 0.769521561388056 0.239831236245449 no 848 0.220791874861592 1061 2853078
SGTC_3160 9100216 49.47 µM 0.768595623075475 0.240098277297103 no 849 0.221066702328689 1062 17191039
SGTC_1943 st076331 65.2 µM 0.768519791502956 0.240120154337456 no 850 0.221089218543815 1164 24208415
SGTC_1647 st011722 22.4 µM 0.765644957083393 0.240950331016449 no 851 0.221943793312766 1062 2854783
SGTC_948 3448-0295 75.3 µM 0.765081848707035 0.241113124570617 no 852 0.222111403840324 1108 678569
SGTC_912 3474-0017 2.18 µM 0.76214089598148 0.241964319239095 no 853 0.222987958458803 1118 3360550
SGTC_1359 1582-0056 520 nM 0.760198731499062 0.242527328800848 no 854 0.223567901561954 1112 3661189
SGTC_15 0266-0086 27.098 µM 0.76007662749108 0.242562748939248 no 855 0.223604391261867 1195 1712902 YIL048W NEO1
SGTC_3073 9114972 49.47 µM 0.759534148702962 0.242720145974248 no 856 0.223766547180349 1010 41905075
SGTC_2886 9058944 51.95 µM 0.759298582712276 0.242788511275916 no 857 0.223836982578187 966 4949929
SGTC_3003 9075612 71.4286 µM 0.758764262681682 0.242943618759362 no 858 0.223996793612083 1068 6501993
SGTC_1495 4469-0029 237 µM 0.757578916695864 0.243287903520493 no 859 0.224351552845731 1150 793680
SGTC_452 diindolylmethane 8 µM 0.756871003066461 0.243493643349365 no 860 0.224563574567762 1020 3071 Inhibits expression of several cancer promoting factors.
SGTC_464 bw-b 70c 158 µM 0.750207505852759 0.245434843028997 no 861 0.226564869459875 1137 5353454
SGTC_1506 4226-2149 212 µM 0.749377535791643 0.245677209685768 no 862 0.226814843399589 1142 991114
SGTC_2892 9047358 58.44 µM 0.748404989110488 0.245961374818506 no 863 0.227107957063001 1088 6466771
SGTC_2446 5162541 200 µM 0.748334516116472 0.245981972935552 no 864 0.227129205054989 1048 1549321
SGTC_1333 1482-0047 286 µM 0.747585612876565 0.246200922414725 no 865 0.22735507268436 1132 3811116
SGTC_1525 8-methoxypsoralen 92.5 µM 0.745104477552958 0.24692705358864 no 866 0.228104281259397 1162 4114 Related to psoralen; DNA damaging agent.
SGTC_750 4073-0104 132 µM 0.744960828149254 0.246969129215909 no 867 0.228147700395758 957 22330957
SGTC_1835 st008666 49.2 µM 0.743666825856808 0.247348321817876 no 868 0.228539031942298 1017 690455
SGTC_2060 5238662 140 µM 0.7429504118881 0.247558392525008 no 869 0.228755851564603 1072 790130
SGTC_870 0573-2213 57.6 µM 0.740191523745785 0.248368257831797 no 870 0.229591895030524 1131 3916321
SGTC_244 nsc-207895 1.295 µM 0.740027089986424 0.248416571540479 no 871 0.229641778435593 1006 42640
SGTC_2629 bisabolol 100 µM 0.739273164570709 0.248638153021589 no 872 0.229870570538957 1121 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1361 1608-0041 5.61 µM 0.738417378868152 0.248889799133467 no 873 0.230130428527137 1127 X1361
SGTC_3263 9137018 49.47 µM 0.738107961521914 0.248980817502058 no 874 0.230224423056336 1096 43844957
SGTC_641 4092-0595 30 µM 0.733603346666026 0.250307900903443 no 875 0.231595260330396 1142 786260
SGTC_2114 5491910 81.25 µM 0.732790596999105 0.250547739988095 no 876 0.231843078602476 1144 2849228
SGTC_579 4491-1009 110 µM 0.732184688687641 0.250726620227911 no 877 0.232027924235312 1293 1271041
SGTC_3064 1327-0027 10 µM 0.731010623188602 0.251073427970188 no 878 0.232386332114496 1026 16000455 YPR107C YTH1
SGTC_3130 9127414 49.47 µM 0.725418148008943 0.252728869143021 no 879 0.234097771453571 1189 1494646
SGTC_757 1066-0008 322 µM 0.725077961293799 0.252829753701395 no 880 0.2342021019513 1133 6842497
SGTC_2654 protoveratrine a 100 µM 0.724590234740478 0.252974429125078 no 881 0.234351725749911 1148 5702278 A heart drug and vasodilator.
SGTC_1645 Cervolide 78 µM 0.723800413429661 0.253208807958769 no 882 0.234594137748418 1102 23173 A fragrance.
SGTC_2816 7982706 58.44 µM 0.72229908521928 0.253654640523884 no 883 0.235055307601895 1146 2981853
SGTC_1319 1306-0155 43.7 µM 0.721854395150332 0.253786774235261 no 884 0.235192001160059 1191 3122360
SGTC_1011 4112-3381 17.4 µM 0.721410086706012 0.253918830633404 no 885 0.235328621239796 1193 2877139
SGTC_647 0140-0236 81 µM 0.721151195074258 0.253995794471276 no 886 0.235408247835021 1191 990837
SGTC_1565 sinapyl alcohol 95.1 µM 0.719978686785499 0.254344513341981 no 887 0.235769059129543 1150 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1737 st035557 69.7 µM 0.719718326710987 0.254421981774195 no 888 0.235849220048716 1026 5716916
SGTC_2248 tofa 1.1 µM 0.719630670190719 0.254448066178862 no 889 0.23587621154255 1097 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1253 0550-0034 176 µM 0.718582433365495 0.254760103987623 no 890 0.236199120089224 1118 5969915
SGTC_1026 k007-1105 30.6 µM 0.718104252177145 0.254902514870398 no 891 0.23634650426214 1141 7066794
SGTC_3168 9103419 49.47 µM 0.717685924795521 0.255027134380113 no 892 0.236475481910372 1120 16649256
SGTC_2606 farnesol 9.78 µM 0.717368857885158 0.255121609677952 no 893 0.236573264986017 1168 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_835 0312-0010 67.2 µM 0.717319598409112 0.255136288991208 no 894 0.236588458549029 1135 1626196
SGTC_1631 benzylvanillin 81.9 µM 0.715077041075912 0.255805038122219 no 895 0.23728071986487 1149 75506
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.714891502229066 0.255860408293941 no 896 0.237338044157489 1171 5355888
SGTC_2536 dehydroabietamide 32.04 µM 0.713617483160833 0.256240781399189 no 897 0.237731871854625 1177 3983547
SGTC_485 niflumic acid 177 µM 0.711910441959619 0.256750900016656 no 898 0.238260117827543 1147 4488 A COX2 inhibitor.
SGTC_2186 6124449 200 µM 0.711418578294089 0.256897982691093 no 899 0.238412444876893 1135 3834182 YLR033W RSC58
SGTC_1013 4112-3890 241 µM 0.710858252165205 0.257065591197939 no 900 0.238586039273612 1103 705171
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.710643090142882 0.257129967013666 no 901 0.238652716905594 1208 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2289 7946404 165.07 µM 0.710606972014867 0.257140774268227 no 902 0.238663910731857 1225 1246120 YPR165W RHO1
SGTC_1526 st051518 75 µM 0.710443730659835 0.257189622239602 no 903 0.238714506510164 1092 673993
SGTC_377 3970-0964 33.1 µM 0.70927667663051 0.257538989319991 no 904 0.239076399519247 1188 16481235
SGTC_2145 5634607 200 µM 0.706275400900793 0.258438576260389 no 905 0.240008443999802 1150 308662
SGTC_2576 guaiol 23.12 µM 0.705746282936026 0.258597339974655 no 906 0.240172966478464 1186 227829
SGTC_527 4476-4215 268 µM 0.705702558316544 0.258610461959895 no 907 0.240186564839945 1135 4418754
SGTC_3307 9126885 69.2785 µM 0.696461159447507 0.261391570517654 no 908 0.243070036592778 1193 24824909
SGTC_1183 1254-0324 198 µM 0.696344314638952 0.261426831895857 no 909 0.243106613595871 1213 5799357
SGTC_814 3342-0569 96 µM 0.695251409072564 0.261756766723116 no 910 0.243448879932048 1234 4346283
SGTC_2391 6285546 200 µM 0.694450694792671 0.261998628089295 no 911 0.243699805571977 1179 846083
SGTC_1620 st003704 16.5 µM 0.693174678195549 0.262384294479388 no 912 0.244099968538566 1183 2834414
SGTC_1560 lithocholic acid 53.1 µM 0.693041471724904 0.262424571881596 no 913 0.244141762940267 1139 9903 A bile acid which acts as a detergent.
SGTC_2518 prenyletin 46.28 µM 0.692874632922457 0.2624750230969 no 914 0.244194115148917 1125 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_490 phenamil 164 µM 0.69276698020598 0.262507579372705 no 915 0.244227898617558 1135 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1119 parthenolide 318.541 nM 0.691738025622323 0.262818859521717 no 916 0.244550931227726 1269 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1916 st067606 49.2 µM 0.685706076811825 0.264647438559757 no 917 0.246449236986225 1231 19590279
SGTC_1161 k007-0610 110 µM 0.685664017412377 0.264660211503812 no 918 0.246462501102526 1242 5843850
SGTC_720 r052-1644 49.9 µM 0.685357166711742 0.264753407933384 no 919 0.246559283041009 1198 1422863 YOR257W CDC31
SGTC_2020 4017018 200 µM 0.684246415258037 0.265090903874611 no 920 0.246909788662067 1232 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1268 0828-0275 2.46 µM 0.683692669896547 0.265259238059201 no 921 0.247084626558264 1248 745337
SGTC_3076 9116187 49.47 µM 0.68263511874148 0.265580875919259 no 922 0.247418718514124 1162 27241210
SGTC_731 3966-0296 387 µM 0.682316268343321 0.265677888141776 no 923 0.247519494183362 1252 660956
SGTC_400 oxethazaine 37.5 µM 0.680396784837293 0.266262282398711 no 924 0.248126628136867 1184 4621 A local anesthetic.
SGTC_2614 arthonioic acid 13.39 µM 0.676518612084397 0.26744498921751 no 925 0.249355716599083 1183 6710684
SGTC_779 1360-0071 233 µM 0.674330458255064 0.268113466723401 no 926 0.250050621966242 1289 7566
SGTC_2719 novobiocin 32.65 µM 0.674274527007932 0.268130564646586 no 927 0.25006839785096 1237 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2228 7354201 200 µM 0.673337779515297 0.268417005552312 no 928 0.250366211467135 1252 753451
SGTC_2401 5128683 200 µM 0.671484564385294 0.268984139100889 no 929 0.250955944715992 1188 708373
SGTC_235 0330-0087 5 mM 0.6704614031656 0.269297511403903 no 930 0.251281851505549 1256 46494818 YHR062C RPP1
SGTC_2134 5324836 1.464 µM 0.670277536717969 0.269353845148274 no 931 0.251340442061297 1200 699272
SGTC_676 falcarinol 140 µM 0.669312141846948 0.269649723650428 no 932 0.251648191546543 1279 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2170 morpholine 200 µM 0.668705264585848 0.269835805396024 no 933 0.251841754287131 1259 121171 Reacts with secondary amines.
SGTC_3095 9117207 49.47 µM 0.667375983215779 0.270243616436511 no 934 0.252266001375197 1201 17015229
SGTC_2139 5578692 56.4705 µM 0.666034074873725 0.270655613673054 no 935 0.252694660337419 1198 650991 YMR113W FOL3
SGTC_312 4092-0653 6.84 µM 0.664398857122293 0.271158087406734 no 936 0.253217532073315 1247 1148278
SGTC_1469 k284-2957 126 µM 0.664248948147058 0.27120417507028 no 937 0.253265494916969 1264 23884841
SGTC_2634 4'-methoxyflavone 100 µM 0.663226993772007 0.271518466346446 no 938 0.253592592819551 1237 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1303 1160-0052 261 µM 0.662717288683225 0.271675288537771 no 939 0.25375581751184 1261 3562476
SGTC_3040 9091894 49.47 µM 0.66150952093957 0.272047065263124 no 940 0.254142805419842 1189 25236966
SGTC_442 cape 100 µM 0.661273668702707 0.27211969513594 no 941 0.254218412319066 1234 5281787
SGTC_194 1486-1323 56.904 µM 0.659970928355236 0.272521043066605 no 942 0.254636242799346 1228 5178754
SGTC_1995 st072814 61.1 µM 0.659898502027759 0.272543364773225 no 943 0.254659482787564 1215 5769371
SGTC_945 3381-0768 11.3 µM 0.659550100854393 0.272650754277937 no 944 0.254771292451873 1265 1126236 YIL048W NEO1
SGTC_3091 9116372 49.47 µM 0.658102210694264 0.273097269853729 no 945 0.255236227716202 1261 17169793
SGTC_867 0518-0118 155 µM 0.657304047734015 0.273343570596834 no 946 0.255492717166951 1289 6848158
SGTC_325 2810-4341 181 µM 0.654210556281157 0.274299212379714 no 947 0.256488080741514 1259 774970
SGTC_3344 9148862 3.898 µM 0.652877510124405 0.274711525156481 no 948 0.256917624435519 1308 4905352
SGTC_279 1273-0055 2.93 µM 0.6520755689548 0.274959713662444 no 949 0.2571762118726 1298 2847562
SGTC_1029 k015-0030 64.7 µM 0.650956179175698 0.275306332281019 no 950 0.257537387356566 1302 2208316
SGTC_984 1492-0255 2.91 µM 0.649919823136909 0.275627431135883 no 951 0.257872006391268 1240 1585198
SGTC_1779 st039427 55 µM 0.649387829841269 0.275792332503847 no 952 0.25804386417567 1317 1124498
SGTC_2033 5192550 145 µM 0.64907332338129 0.275889842517639 no 953 0.258145491852726 1247 182073
SGTC_910 3454-3003 490 µM 0.64468107565587 0.2772533881712 no 954 0.259566941245374 1239 820824
SGTC_347 4534-1311 26.2 µM 0.643974520161529 0.277473041262521 no 955 0.25979597835618 1279 2862016
SGTC_2894 9048625 32.47 µM 0.643952891940019 0.277479766358519 no 956 0.259802991007524 1350 4092861
SGTC_2820 7989630 71.43 µM 0.643629696236555 0.277580270570654 no 957 0.259907794372707 1178 2984098
SGTC_3185 9108267 49.47 µM 0.642580906911392 0.277906535189303 no 958 0.260248037682841 1243 4910486
SGTC_801 0866-0028 10.1 µM 0.641081846334981 0.278373198021722 no 959 0.260734754058326 1300 6849771
SGTC_131 0141-0277 33.849 µM 0.641008033542771 0.278396186065543 no 960 0.260758731757851 1272 1547771
SGTC_2194 5927483 104.545 µM 0.639114872665072 0.278986102584623 no 961 0.261374102660613 1291 760979
SGTC_2857 9024691 58.44 µM 0.638805547897347 0.279082547178846 no 962 0.261474719350008 1301 16478292
SGTC_2299 7976368 114.88 µM 0.63863295009043 0.279136368620323 no 963 0.261530870344869 1288 2979718
SGTC_1418 3966-3099 2.4 µM 0.638328807201175 0.279231222247423 no 964 0.261629831774025 1294 740335
SGTC_1727 st034309 9.9045 µM 0.637767898939013 0.279406194859302 no 965 0.261812389417022 1350 870305
SGTC_2476 5806916 10.51 µM 0.636858787556833 0.279689900806652 no 966 0.262108414715033 1217 2870194
SGTC_1387 3342-1166 1.8 µM 0.636503811966607 0.2798007158044 no 967 0.26222404859032 1285 3418228
SGTC_3286 9117135 37.221 µM 0.635537409837377 0.280102511611339 no 968 0.262538988029987 1249 3438150
SGTC_1685 st024049 53.0905 µM 0.634991515256781 0.280273057646632 no 969 0.262716974381769 1277 1941139
SGTC_2154 5570129 200 µM 0.634491469785694 0.28042932382534 no 970 0.262880065999663 1297 673366
SGTC_1941 st076221 61.8 µM 0.632831064875885 0.280948509248986 no 971 0.263421984092812 1280 2828568
SGTC_183 3914-0051 30.55 µM 0.631241213372619 0.281446068571063 no 972 0.263941409107937 1290 1596232
SGTC_1461 k072-0203 53.8 µM 0.630682516248866 0.281621019115748 no 973 0.264124066555943 1240 5418714
SGTC_854 0422-0053 192 µM 0.629909043747667 0.281863310996758 no 974 0.264377047757768 1288 3596728
SGTC_1439 4092-1168 46 µM 0.629716423180349 0.281923665410931 no 975 0.264440067730752 1299 2886240
SGTC_2983 9022671 12.99 µM 0.62944790453754 0.28200781159787 no 976 0.264527932152034 1344 6405161
SGTC_2058 5236698 133 µM 0.626198185500674 0.283027139971597 no 977 0.265592478617769 1298 766665
SGTC_1370 2001-0092 44.6 µM 0.625193733887804 0.283342560325152 no 978 0.265921956997682 1419 790957
SGTC_2506 ethyl hematommate 54.16 µM 0.624549936268657 0.28354481582877 no 979 0.266133243167967 1264 3940691 An allergen.
SGTC_749 1000-0129 128 µM 0.621723344783934 0.284433635703268 no 980 0.267061899251129 1378 708470
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.621716561678695 0.284435770246405 no 981 0.267064129757459 1337 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1426 4048-4480 71.7 µM 0.621589922508074 0.284475623130077 no 982 0.267105774576001 1329 14224343
SGTC_2439 5492030 7.2 µM 0.621558720334872 0.284485442749382 no 983 0.267116035797576 1273 5722370
SGTC_277 nystatin 15.5 µM 0.621093668212814 0.284631818242216 no 984 0.267268997538557 1277 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1334 1486-0610 236 µM 0.620999842921591 0.284661354179328 no 985 0.267299863264613 1310 3742339
SGTC_1822 st052468 42 µM 0.620283173924566 0.284887007817734 no 986 0.267535685338567 1293 2873678
SGTC_2780 5215298 71.43 µM 0.618984736539944 0.285296056894884 no 987 0.267963207066605 1302 2834131
SGTC_180 1486-1293 102.781 µM 0.616524770674653 0.286071790667877 no 988 0.26877411424639 1386 4140536
SGTC_2031 5180455 200 µM 0.615846200730798 0.286285949380719 no 989 0.268998015861804 1278 29949
SGTC_752 1896-0090 130 µM 0.615587934325546 0.286367479029076 no 990 0.269083258294153 1319 772567
SGTC_786 4544-0069 423 µM 0.613305781879375 0.287088388418981 no 991 0.269837085515956 1382 748821 YLR208W SEC13
SGTC_828 2074-0507 139 µM 0.612140950310816 0.28745667814417 no 992 0.270222252994541 1391 X828
SGTC_2770 toltrazuril 17.5 µM 0.610660983048627 0.287924927687503 no 993 0.270712020639653 1308 68591 Kills coccidiodes.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.610369618124867 0.288017155581565 no 994 0.270808494636906 1338 3256 An antibiotic and ribosome inhibitor.
SGTC_1621 st003705 32.4 µM 0.610063204124129 0.288114162112331 no 995 0.270909970052807 1339 24207032
SGTC_603 3794-0023 45.9 µM 0.608991698677603 0.28845350741649 no 996 0.271264970652131 1328 3802260
SGTC_3255 9139072 49.47 µM 0.608189881099711 0.288707565854394 no 997 0.271530772526529 1330 17646060
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.608006338879651 0.288765736605626 no 998 0.27159163486292 1334 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1336 1486-0901 104 µM 0.606791021080277 0.289151051184276 no 999 0.271994803824901 1360 5006114
SGTC_3094 9117742 49.47 µM 0.606085201267649 0.289374941149376 no 1000 0.272229088712764 1278 17149698
SGTC_1139 k015-0024 46.9 µM 0.604160358769388 0.289985925454249 no 1001 0.2728685166981 1325 2766652
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.602651435561753 0.290465310992493 no 1002 0.273370297631101 1398 6710655
SGTC_2445 5742597 35.57 µM 0.602027229167088 0.290663730033912 no 1003 0.273578006243409 1307 1774255
SGTC_2884 9058502 51.95 µM 0.601930177736113 0.290694585863618 no 1004 0.273610307732824 1334 6471554
SGTC_2859 9028643 45.46 µM 0.599219995088452 0.291556859782351 no 1005 0.274513095381022 1290 17151580
SGTC_2639 lactacystin 53 µM 0.598773351259301 0.291699078742684 no 1006 0.27466201764156 1378 3870 A proteasome inhibitor.
SGTC_3278 9139605 49.47 µM 0.598381445062759 0.291823894939484 no 1007 0.274792721811987 1372 7958859
SGTC_2441 5730946 39.09 µM 0.598054335575633 0.291928093411129 no 1008 0.274901839180651 1379 1774275
SGTC_3309 9129340 25.759 µM 0.597286409453687 0.292172779041153 no 1009 0.27515808828803 1394 17158987
SGTC_3323 9138564 53.9225 µM 0.596867763626723 0.292306213066676 no 1010 0.275297835647784 1359 43912313 YNL103W MET4
SGTC_1711 st032263 62.8 µM 0.59659352925992 0.292393634518782 no 1011 0.275389396227504 1366 3958979
SGTC_1969 st069479 40.1 µM 0.592729397818362 0.293626747105612 no 1012 0.276681131993916 1385 3895485
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.591922835720199 0.293884438704367 no 1013 0.276951130716171 1322 75037 A free radical scavenger.
SGTC_1228 0124-0032 52.5 µM 0.591573472666077 0.29399609049529 no 1014 0.277068120916765 1433 X1228
SGTC_484 loperamide 105 µM 0.590974118993734 0.294187681635335 no 1015 0.277268881078035 1335 3955 An opioid-receptor agonist.
SGTC_2067 5224629 34.075 µM 0.590842464636456 0.294229774376719 no 1016 0.277312989694343 1336 2835000
SGTC_148 3253-0744 288.01 µM 0.590185791900849 0.294439768368147 no 1017 0.277533048269651 1307 6893655
SGTC_3083 9117465 49.47 µM 0.587729566240263 0.295225844789943 no 1018 0.27835691344563 1326 16420915
SGTC_425 3825-7017 13.1 µM 0.587518299700477 0.295293502422119 no 1019 0.278427831927894 1439 3397440
SGTC_1847 st056231 15 µM 0.587066436416529 0.295438234565665 no 1020 0.278579544076064 1370 5393180
SGTC_95 0471-0001 561.058 µM 0.586767292936095 0.295534068390988 no 1021 0.278680003016113 1269 4015405
SGTC_2761 levamisole 97.89 µM 0.583687848074657 0.296521431479333 no 1022 0.279715172217861 1439 26879 An alkaline phosphatase inhibitor.
SGTC_1250 0485-0349 40.2 µM 0.581428811554107 0.297246706556072 no 1023 0.280475742030274 1365 6842794 YDL195W SEC31
SGTC_3317 9138495 8.753 µM 0.581388865998423 0.297259538570057 no 1024 0.280489199855888 1347 17020139
SGTC_3354 9151612 71.43 µM 0.581313839605582 0.29728364055181 no 1025 0.280514477407786 1403 27261949
SGTC_1321 1326-2144 215 µM 0.581019600287927 0.297378172581264 no 1026 0.280613621823131 1376 3513030
SGTC_2372 9071633 200 µM 0.58088053421029 0.297422855951688 no 1027 0.280660486262939 1388 21321366
SGTC_1831 st055328 12 µM 0.580651549648656 0.297496437742648 no 1028 0.280737660945138 1391 1103068
SGTC_1836 st055642 81 µM 0.580603823518641 0.297511775081432 no 1029 0.28075374737834 1303 8571
SGTC_3229 9132204 49.47 µM 0.580370349094795 0.297586809965309 no 1030 0.280832448025134 1397 17682924
SGTC_489 paxilline 115 µM 0.58005820348182 0.297687141982517 no 1031 0.280937684183093 1313 105008 A toxic potassium channel blocker.
SGTC_951 1171-0579 82.7 µM 0.579972386951587 0.297714728434223 no 1032 0.280966619539233 1320 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1730 st033808 45.1 µM 0.579785442269403 0.297774827425822 no 1033 0.28102965796315 1428 1045166
SGTC_2866 9034245 58.44 µM 0.578333685670324 0.298241726487834 no 1034 0.281519428000277 1362 6462273
SGTC_840 0245-0196 390 µM 0.577979321160132 0.29835574416399 no 1035 0.281639040226862 1436 3827528
SGTC_2707 st078556 66.6 µM 0.577925806746576 0.298372964285964 no 1036 0.281657105616147 1377 17250899
SGTC_736 0958-0254 92.6 µM 0.577881605932493 0.298387187774818 no 1037 0.281672027342971 1417 6812352
SGTC_2709 st078560 56 µM 0.577320103636167 0.298567901835934 no 1038 0.281861617741547 1436 17250903
SGTC_613 3914-0030 117 µM 0.57384696136552 0.299686803472207 no 1039 0.283035683423448 1250 1145395
SGTC_438 sphingosine 6.67 µM 0.572766788147738 0.300035177084062 no 1040 0.28340130459316 1236 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3281 9140613 49.47 µM 0.569528783104191 0.301080582988994 no 1041 0.284498671609272 1286 16013766
SGTC_3283 9109332 35.8195 µM 0.569098436824051 0.301219645908062 no 1042 0.284644669570233 1326 17027281
SGTC_255 tunicamycin 200.472 nM 0.568364308553034 0.301456940270061 no 1043 0.28489381020467 1386 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3186 9110464 49.47 µM 0.566702591324317 0.301994372320239 no 1044 0.285458129999084 1411 17018021
SGTC_2257 7960413 200 µM 0.56475714847256 0.302624113057217 no 1045 0.286119478632514 1377 2974689 YIL048W NEO1
SGTC_2315 7733312 200 µM 0.56424929424868 0.302788602507569 no 1046 0.28629224219373 1363 726316
SGTC_688 0527-0193 473 µM 0.562748631330729 0.303274887620753 no 1047 0.286803031963953 1411 4007154
SGTC_1482 3346-2049 8.48 µM 0.561797102368767 0.303583408345468 no 1048 0.287127133282051 1397 3826804
SGTC_1914 st062367 72.6 µM 0.560485332457594 0.304008962051466 no 1049 0.287574220755842 1391 978205
SGTC_2711 st079103 59.1 µM 0.55939862435272 0.304361704309898 no 1050 0.287944850007662 1428 54693780
SGTC_1668 st014914 51.6 µM 0.558726800217207 0.304579867555764 no 1051 0.288174092989914 1400 2839556
SGTC_3084 9116877 49.47 µM 0.555959281235522 0.305479303914856 no 1052 0.28911934553722 1346 27241325
SGTC_2847 9005661 71.43 µM 0.555538785226673 0.305616066995542 no 1053 0.289263094426897 1327 2991449
SGTC_637 1181-0519 7.26 µM 0.555301318606438 0.305693313165622 no 1054 0.289344288545647 1398 6252091 YGR060W ERG25
SGTC_3001 9076041 71.4286 µM 0.554659966861459 0.305901983448186 no 1055 0.289563631772432 1393 16004211
SGTC_3336 9143619 71.43 µM 0.553061427627412 0.306422358555945 no 1056 0.290110674039155 1423 45595730
SGTC_1430 4049-0248 69.1 µM 0.550118980654765 0.30738123894075 no 1057 0.291118884439079 1485 22774488
SGTC_761 k216-0224 480 µM 0.548868556734814 0.307789124766483 no 1058 0.291547828977356 1531 1340404
SGTC_2298 7976326 193.81 µM 0.548530445385355 0.307899456863586 no 1059 0.291663865056486 1327 2235818
SGTC_2809 7964133 12.99 µM 0.548016993618487 0.308067039052768 no 1060 0.291840117184979 1442 1253665
SGTC_963 1269-2853 151 µM 0.546130776767918 0.308683012521865 no 1061 0.292488022703303 1372 3668223
SGTC_1806 st050005 60.3 µM 0.544790745099705 0.309120948143934 no 1062 0.292948722310371 1380 5194765
SGTC_1688 st021091 57.6 µM 0.544468871321113 0.309226180128783 no 1063 0.293059431862731 1447 3656366
SGTC_1014 4130-3005 69.3 µM 0.54405935097634 0.309360089518104 no 1064 0.293200315789166 1400 743608
SGTC_2218 6965428 192.983 µM 0.543982036974466 0.309385373328305 no 1065 0.293226917014632 1453 675684
SGTC_1390 3413-2614 145 µM 0.543787624782431 0.309448955462785 no 1066 0.293293812850251 1417 3421432
SGTC_2063 5246145 200 µM 0.54305853082294 0.309687455045607 no 1067 0.293544751815277 1459 711240
SGTC_803 4488-1585 147 µM 0.542059830970838 0.310014277578715 no 1068 0.293888644790436 1402 747204
SGTC_678 1218-2179 85.9 µM 0.54052965003867 0.310515317488394 no 1069 0.294415909471455 1454 6820081 YOR116C RPO31
SGTC_1084 voriconazole 435 nM 0.540419743938635 0.310551318510044 no 1070 0.294453797355644 1440 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2989 9073649 71.4286 µM 0.540128998113563 0.310646564436152 no 1071 0.294554036893323 1424 21367202
SGTC_1098 clofazimine 15.1 µM 0.539401167160381 0.310885051481903 no 1072 0.294805037935947 1472 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2700 st077718 96.8 µM 0.538965097896985 0.311027975576881 no 1073 0.2949554687585 1424 904970
SGTC_1739 st037196 92.5 µM 0.538312540328744 0.311241908144536 no 1074 0.295180647597833 1483 612214
SGTC_1220 1838-0075 193 µM 0.538285626316022 0.311250732925743 no 1075 0.295189936548423 1410 5529645
SGTC_1066 ketoconazole 628 nM 0.536320441091243 0.311895386419472 no 1076 0.295868552839638 1499 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2347 9049783 174.81 µM 0.531671899753128 0.313422572827523 no 1077 0.297476628702134 1500 6467988 YPL169C MEX67
SGTC_1379 2144-0755 36.5 µM 0.531375961974098 0.313519906099206 no 1078 0.29757913782989 1484 5392327
SGTC_1132 3456-3614 2.5 µM 0.531314597985723 0.313540090203069 no 1079 0.297600395562526 1632 3125502
SGTC_175 3793-3120 23.7 µM 0.530991495363125 0.31364637569876 no 1080 0.297712336308105 1423 5322297
SGTC_2752 diclazuril 33.15 µM 0.529445713473002 0.314155078834075 no 1081 0.298248146859689 1461 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2737 bleomycin 30.5 nM 0.529306282699335 0.314200981650826 no 1082 0.298296498987262 1443 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.528561955321164 0.314446074608159 no 1083 0.29855467892154 1522 94937 An inhibitor of serotonin biosynthesis.
SGTC_317 4495-0002 170 µM 0.527944570473263 0.314649429863067 no 1084 0.298768904222716 1400 15991618
SGTC_89 0302-0250 142.109 µM 0.52665302648078 0.315075022597467 no 1085 0.299217280632577 1507 4203518 YLR208W SEC13
SGTC_2337 9009472 200 µM 0.526627156302751 0.315083549912697 no 1086 0.299226264922175 1537 5742383
SGTC_2749 bexarotene 57.39 µM 0.524744020761925 0.315704532544923 no 1087 0.299880575545728 1416 82146 An retinoic acid receptor inhibitor.
SGTC_1851 st056236 18.9 µM 0.522329518752819 0.316501500183674 no 1088 0.300720459937258 1494 5393171
SGTC_2683 piperine 63.03 µM 0.521469024885633 0.31678573433089 no 1089 0.301020039042784 1435 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2339 9000433 200 µM 0.520870555587892 0.316983481597557 no 1090 0.301228474139449 1407 2988954
SGTC_1207 2099-0101 141 µM 0.520461566046986 0.317118650712663 no 1091 0.301370954543045 1481 5837381
SGTC_3067 9117431 49.47 µM 0.520164245953183 0.317216928922149 no 1092 0.301474551506528 1453 17150885
SGTC_961 1252-1571 372 µM 0.520034548617825 0.317259804001695 no 1093 0.30151974772048 1559 6813498
SGTC_1159 4092-0538 61.2 µM 0.519467072080017 0.317447428069465 no 1094 0.301717534664295 1494 717301
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.519031547452669 0.3175914568606 no 1095 0.301869370951488 1383 88881 An O-methylated flavonoid and antioxidant.
SGTC_1288 0973-0013 65.5 µM 0.517875227445823 0.317973987939914 no 1096 0.302272663530899 1498 4315430
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.517310973105633 0.318160723806918 no 1097 0.302469547635871 1516 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2433 5607874 27.82 µM 0.517276208956266 0.31817223026141 no 1098 0.302481679699108 1419 2252428
SGTC_360 0957-0399 1.01 µM 0.516513461836844 0.318424733194335 no 1099 0.302747919620032 1544 6752301 YPR165W RHO1
SGTC_1913 st060213 96.1 µM 0.515713518457058 0.318689640374279 no 1100 0.30302725575173 1522 688959
SGTC_1981 st071826 47 µM 0.509524516687483 0.320742298249539 no 1101 0.305192309030513 1436 11838600
SGTC_1215 3852-0577 11.2 µM 0.507387409854269 0.321452374901989 no 1102 0.305941508931651 1573 2884876
SGTC_1457 k015-0032 57.3 µM 0.505079555802935 0.322219917505045 no 1103 0.306751479994227 1469 4302660
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.504835966364504 0.322300974432888 no 1104 0.306837026013942 1517 364106
SGTC_1204 4049-0315 18.3 µM 0.502253832251572 0.323160725429737 no 1105 0.307744490143016 1584 588402
SGTC_3318 9139014 38.6185 µM 0.501736290285609 0.323333160819012 no 1106 0.307926516692583 1473 16643984
SGTC_2664 lyso-paf C-16 73.48 µM 0.501497815143298 0.323412629092752 no 1107 0.308010407556164 1490 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3016 9080866 49.47 µM 0.501289899097524 0.323481920578784 no 1108 0.308083556518183 1443 17066299
SGTC_2773 thioridazine 9.09 µM 0.499393234853389 0.324114297921602 no 1109 0.308751192090204 1485 5452 An antipsychotic.
SGTC_3195 9113082 49.47 µM 0.497228869594532 0.324836551327845 no 1110 0.309513832611835 1520 17018038
SGTC_1417 3966-0327 90.4 µM 0.497214881991054 0.324841221167544 no 1111 0.309518763988253 1522 651118
SGTC_1721 st082152 9.2685 µM 0.495747128140087 0.325331391870921 no 1112 0.310036415999541 1434 5296051
SGTC_516 3992-2719 87.3 µM 0.495730882188024 0.325336819058165 no 1113 0.31004214778259 1386 5350887 YDR037W KRS1
SGTC_2069 5228469 200 µM 0.49450148956186 0.325747622232888 no 1114 0.310476027317848 1437 2835210
SGTC_1392 3455-1037 33.9 µM 0.494158544563543 0.325862255540774 no 1115 0.310597107193813 1535 981132
SGTC_2101 5377231 179.231 µM 0.493922339689885 0.325941219310705 no 1116 0.310680513425161 1576 2844213
SGTC_1845 st056753 3.01 µM 0.493337155047425 0.326136881352091 no 1117 0.310887189707932 1416 5375839
SGTC_1900 st060200 72.8 µM 0.493167735524391 0.326193537316666 no 1118 0.310947036659862 1492 688945
SGTC_2216 7189485 200 µM 0.493042876180973 0.326235294378874 no 1119 0.310991146059173 1542 731273
SGTC_2361 9034121 116 µM 0.492512561540388 0.326412673268862 no 1120 0.311178522006033 1487 6496917
SGTC_1280 0880-0253 10.1 µM 0.492073751570451 0.326559475493479 no 1121 0.311333603637635 1472 6836607
SGTC_2596 sinensetin 100 µM 0.489254593658732 0.327503254014462 no 1122 0.312330731547714 1468 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1059 3448-6867 171 µM 0.488978747900484 0.327595659141855 no 1123 0.312428371403463 1513 3934407
SGTC_822 1487-0950 154 µM 0.488764754877291 0.32766735159571 no 1124 0.312504126603038 1517 1958375
SGTC_1664 st014217 9.02 µM 0.488741382663172 0.327675182195633 no 1125 0.312512401029189 1548 3982782
SGTC_666 0272-0154 136 µM 0.488628351009935 0.327713053261144 no 1126 0.312552418771498 1498 6870312
SGTC_2428 5615643 7.78 µM 0.488378942081763 0.327796623572758 no 1127 0.312640727361923 1529 2253075
SGTC_1375 2910-0797 186 µM 0.487895531727436 0.327958626108101 no 1128 0.312811919812593 1526 742508
SGTC_849 0386-0493 241 µM 0.486368311525925 0.328470647236196 no 1129 0.313353026865133 1459 726119
SGTC_2121 5257820 149.641 µM 0.481936242005294 0.32995838022196 no 1130 0.31492561972781 1563 791256
SGTC_2093 5331342 194.4 µM 0.481672631135597 0.330046952777939 no 1131 0.315019260673743 1556 33839
SGTC_81 0411-0046 9.971 µM 0.480658104295032 0.330387919969775 no 1132 0.315379756000764 1442 12925265
SGTC_2808 7946468 45.46 µM 0.48054699897928 0.330425269355965 no 1133 0.315419246124243 1550 2970879
SGTC_447 ml7 120 µM 0.480531415508778 0.330430508061807 no 1134 0.315424785120323 1592 4216 Selective myosin light chain kinase inhibitor.
SGTC_940 3232-1287 54.8 µM 0.480287546330661 0.330512494057137 no 1135 0.315511471498454 1498 1585493 YIL048W NEO1
SGTC_26 0302-0163 425.158 µM 0.479026412080118 0.330936602525707 no 1136 0.315959919528961 1530 3100915
SGTC_2226 7298446 200 µM 0.478900073904769 0.330979100924089 no 1137 0.316004859194089 1576 3283010
SGTC_1490 4089-0339 670 nM 0.477382332923779 0.331489817911857 no 1138 0.316544946173296 1560 742542
SGTC_1984 st072354 53.1 µM 0.47626531977159 0.331865891057294 no 1139 0.316942684579963 1521 5762938
SGTC_333 3486-0131 40.1 µM 0.474241343638826 0.33254774973984 no 1140 0.317663907093948 1620 6744690
SGTC_1065 prochlorperazine maleate 2.48 µM 0.473488615017134 0.332801478554584 no 1141 0.317932310798097 1534 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_920 mycophenolic acid 780.421 nM 0.472893152672821 0.333002250517743 no 1142 0.318144705172279 1519 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1564 D-Arginine 115 µM 0.472336760874653 0.333189892343694 no 1143 0.318343217604132 1426 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2922 7999257 32.47 µM 0.472278549256142 0.333209526489238 no 1144 0.318363989671553 1484 2988377
SGTC_1005 4092-0690 4.4 µM 0.471614140457925 0.333433656719148 no 1145 0.318601115849601 1487 1529343
SGTC_1743 st037606 46.3785 µM 0.470751186355 0.333724852579449 no 1146 0.31890921338247 1538 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2140 5586273 200 µM 0.469907702561574 0.33400957518711 no 1147 0.319210480480116 1514 854421
SGTC_1485 3909-9022 254 µM 0.469776998931081 0.334053703474645 no 1148 0.319257174586099 1515 714516
SGTC_2855 9016525 58.44 µM 0.467894736105584 0.334689449062349 no 1149 0.31992993399747 1485 43811474
SGTC_1181 1222-0449 220 µM 0.467233012149746 0.334913063057482 no 1150 0.320166588657587 1592 658318
SGTC_2841 9004761 38.96 µM 0.466255137214001 0.335243619977235 no 1151 0.320516443455151 1431 2991039
SGTC_3069 9117009 49.47 µM 0.46424903478215 0.335922154026197 no 1152 0.321234666819876 1487 41904981
SGTC_1023 4482-3888 16 µM 0.464206568889882 0.33593652326851 no 1153 0.321249877669428 1634 3303168
SGTC_1166 k206-0078 225 µM 0.462979736316156 0.336351751756197 no 1154 0.3216894459636 1506 5404595
SGTC_2792 7535235 81.82 µM 0.462547772608113 0.336497999898448 no 1155 0.321844275986699 1478 1281891
SGTC_2916 7875993 68.79 µM 0.460642853647345 0.337143235161974 no 1156 0.322527430442803 1667 1299250
SGTC_1172 0370-0043 85 µM 0.459103157531692 0.337665112377521 no 1157 0.323080044663716 1590 376585
SGTC_962 1254-0300 21.5 µM 0.458723262520516 0.337793925179106 no 1158 0.323216453390545 1559 7340576
SGTC_746 1095-0025 46.6 µM 0.458490706795441 0.337872788327885 no 1159 0.323299968799723 1636 6749286
SGTC_93 0109-0045 59.227 µM 0.457400365273852 0.338242634424392 no 1160 0.323691650930265 1558 88733
SGTC_755 1995-0008 37.3 µM 0.456058909878015 0.338697873063761 no 1161 0.324173808440979 1543 689533
SGTC_807 1315-0151 48 µM 0.453588125274406 0.339536979452876 no 1162 0.325062650964959 1669 4011080
SGTC_1675 st018485 24.5 µM 0.450459583943978 0.340600609342247 no 1163 0.326189545022905 1557 3323024
SGTC_1284 0929-0043 16 µM 0.449115309500126 0.34105802102957 no 1164 0.326674238523025 1544 1239883
SGTC_2419 paclitaxel 166.5 µM 0.449051272632634 0.341079816473027 no 1165 0.326697335056438 1576 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1493 4348-0038 111 µM 0.448985119790078 0.341102332661847 no 1166 0.326721195467805 1606 800424
SGTC_1953 st076800 12.1 µM 0.447184860768213 0.34171529690034 no 1167 0.327370795679141 1506 297591
SGTC_1448 4255-0083 152 µM 0.44600778411383 0.3421163017287 no 1168 0.327795811551532 1700 5399660
SGTC_1682 st012968 530 nM 0.440963552368426 0.343836776038829 no 1169 0.329619691748447 1514 24207270
SGTC_1607 st000305 50.6 µM 0.440186362213803 0.344102147017304 no 1170 0.329901068169524 1610 5457690
SGTC_2288 7946289 167.31 µM 0.436875209104132 0.345233596866824 no 1171 0.331100925877483 1702 1246052
SGTC_2982 9019404 25.97 µM 0.435353768389071 0.345753951357262 no 1172 0.331652831174854 1401 22333232
SGTC_2472 5377652 49.4 µM 0.433353226737847 0.346438608793307 no 1173 0.332379087559635 1545 1610903
SGTC_2071 5230951 39.92 µM 0.431689796676808 0.347008276882236 no 1174 0.332983442089277 1582 1799272
SGTC_530 4358-1714 28 µM 0.431327416045495 0.347132425830573 no 1175 0.3331151592301 1639 1564641
SGTC_1628 st004252 77.7 µM 0.43074468182052 0.347332100707587 no 1176 0.333327013074798 1694 692968
SGTC_1200 1643-0193 18.4 µM 0.430324105518512 0.347476238229664 no 1177 0.333479947226406 1588 5403974
SGTC_2512 diallyl trisulfide 49.23 µM 0.430042557514992 0.347572741089069 no 1178 0.333582341990089 1568 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_164 4100-3994 89.624 µM 0.42905359287227 0.347911794992797 no 1179 0.333942111738673 1708 4615967
SGTC_1190 1486-1332 13 µM 0.428179580323006 0.348211540308256 no 1180 0.334260190836018 1539 4150046
SGTC_410 α-linolenic acid 100 µM 0.42488411924158 0.34934258053047 no 1181 0.335460576004474 1663 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1804 st050076 49.1 µM 0.423394933503019 0.349854126170951 no 1182 0.336003570393978 1625 3895976
SGTC_2787 5284540 71.43 µM 0.422590241448602 0.350130657015529 no 1183 0.336297123846363 1588 736958
SGTC_2203 7227154 166.4 µM 0.4223917398275 0.35019888393565 no 1184 0.336369553037723 1597 896304
SGTC_696 1560-0013 611 µM 0.422265618646564 0.350242235513018 no 1185 0.3364155752386 1640 1650269
SGTC_2342 7990637 118.86 µM 0.421982817768977 0.350339449625319 no 1186 0.336518779492636 1628 2033102 YER133W GLC7
SGTC_1925 st057770 10.1 µM 0.421879485372907 0.350374973061622 no 1187 0.336556492288759 1504 5989122
SGTC_2728 chlorpromazine 9.18 µM 0.421606208703977 0.350468925959589 no 1188 0.336656236864029 1618 2726 A thorazine and dopamine antagonist.
SGTC_2474 5321570 43.32 µM 0.421604488643349 0.3504695173478 no 1189 0.336656864713693 1675 2841384
SGTC_2019 4016004 108 µM 0.419334776711652 0.351250201004634 no 1190 0.337485742013402 1543 45595336
SGTC_2874 9043904 71.43 µM 0.418959806927206 0.351379235084028 no 1191 0.337622753488719 1588 4463428
SGTC_1904 st060225 78 µM 0.416481954587483 0.352232340186769 no 1192 0.338528684684602 1568 66595
SGTC_403 arphamenine a 50 µM 0.414695761873878 0.352847774136301 no 1193 0.339182317641056 1647 5487158 An arginine aminopeptidase inhibitor.
SGTC_2929 9013348 24.6 µM 0.411572992815485 0.353924651119643 no 1194 0.34032621509397 1603 2995952
SGTC_3012 9080433 71.4286 µM 0.408774353692462 0.354890747158086 no 1195 0.341352631220337 1722 17688859
SGTC_492 tmb-8 126 µM 0.408418713737259 0.355013581811325 no 1196 0.341483148386033 1667 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2868 9035608 32.47 µM 0.40701651456626 0.355498034790125 no 1197 0.341997929449917 1563 6462614
SGTC_1142 3253-1408 9.78 µM 0.406532956913971 0.355665155801477 no 1198 0.342175523293085 1653 256655
SGTC_2179 6298986 200 µM 0.406140713440978 0.355800738359009 no 1199 0.342319606275619 1727 738374
SGTC_2861 9024595 19.48 µM 0.405967843173255 0.355860498346766 no 1200 0.342383114082599 1626 16482810
SGTC_323 4013-0906 34.3 µM 0.404581399991604 0.356339909628621 no 1201 0.342892616463124 1733 2910086
SGTC_3043 9092303 49.47 µM 0.403943608842823 0.356560524576126 no 1202 0.343127093636888 1540 25236084
SGTC_1810 st050138 53 µM 0.403537338768154 0.356701080330737 no 1203 0.343276486040127 1719 3444541
SGTC_1735 st034310 56.75 µM 0.402963136137843 0.356899768275081 no 1204 0.343487671863794 1705 871153
SGTC_3113 9123498 49.47 µM 0.402099969215316 0.357198517859266 no 1205 0.343805227713976 1647 8897275
SGTC_3273 9137859 49.47 µM 0.400211892543918 0.357852302660286 no 1206 0.34450022800024 1671 2377234
SGTC_2251 lansoprazole 556 µM 0.399531624585507 0.35808796156156 no 1207 0.344750763221879 1582 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_671 0560-0003 407 µM 0.398012275537073 0.358614490684107 no 1208 0.345310568561976 1683 3238678
SGTC_2627 acetyl isogambogic acid 100 µM 0.397268948662941 0.358872187986847 no 1209 0.345584571356535 1555 6857789 A caspase activator and apoptosis inducer.
SGTC_250 brefeldin a 552.239 µM 0.39584732259203 0.359365217584541 no 1210 0.346108831927821 1603 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2348 9022543 33.42 µM 0.393972514347641 0.360015771902299 no 1211 0.346800665957152 1661 3162678 YDL140C RPO21
SGTC_1451 4152-0210 104 µM 0.392591300764752 0.360495309606538 no 1212 0.347310682860906 1738 659563
SGTC_2382 9035899 200 µM 0.391977240666631 0.360708573066242 no 1213 0.347537515116462 1633 6462679
SGTC_41 0478-0632 82.643 µM 0.391333700593121 0.360932121435937 no 1214 0.347775295799204 1757 3750424
SGTC_996 3970-0799 1.8 µM 0.388387079586242 0.361956303493398 no 1215 0.348864802134865 1733 6615648 YGL040C HEM2
SGTC_3249 9135183 49.47 µM 0.38807701521152 0.362064132854545 no 1216 0.348979520409666 1683 4902779
SGTC_808 0711-0032 135 µM 0.382191609434857 0.364112935032096 no 1217 0.351159622503409 1793 4252555
SGTC_19 0279-0214 38.434 µM 0.382057543601984 0.36415965098595 no 1218 0.351209341288909 1686 3566274 YBR002C RER2
SGTC_3026 9090633 49.47 µM 0.381552323303196 0.364335715821555 no 1219 0.351396726888462 1620 25236842
SGTC_3089 9117425 49.47 µM 0.380966283755385 0.364539981320204 no 1220 0.351614133503316 1599 9401657
SGTC_982 1491-0518 27.5 µM 0.379289664546026 0.365124583278154 no 1221 0.352236386898599 1668 3091256
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.378828388826676 0.365285475514082 no 1222 0.352407652322602 1650 4620898
SGTC_1887 st057648 70.8 µM 0.376206566689998 0.366200412564912 no 1223 0.353381666953743 1789 688672
SGTC_3024 9090631 49.47 µM 0.376168224628079 0.366213798450915 no 1224 0.353395918287572 1789 25236383
SGTC_1365 1672-3266 55.4 µM 0.373932756512308 0.366994520523004 no 1225 0.354227172604716 1758 6415873
SGTC_1397 3532-0190 20.1 µM 0.371765125277524 0.367752076703038 no 1226 0.35503386577471 1694 5322280
SGTC_1530 rhein 70.4 µM 0.371328412010476 0.367904764155667 no 1227 0.355196469287306 1680 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2870 9038528 12.99 µM 0.370727464993707 0.368114906548609 no 1228 0.355420265832882 1638 6463316
SGTC_785 1270-0111 65.3 µM 0.370086135704324 0.368339213569277 no 1229 0.355659155998958 1656 6741994
SGTC_973 1325-0077 65.9 µM 0.369734734108281 0.368462136467443 no 1230 0.355790074410319 1787 2835149
SGTC_3081 9117243 49.47 µM 0.369326708071968 0.368604883908636 no 1231 0.355942110202918 1787 45595589
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.369207307819944 0.368646659380436 no 1232 0.35598660461973 1634 229346 A bile salt which induces apoptosis.
SGTC_1352 1496-0991 99 µM 0.368477122830264 0.368902168499248 no 1233 0.356258750179742 1658 3000039
SGTC_2669 eugenol 100 µM 0.36756049271322 0.369223001234318 no 1234 0.356600488925543 1777 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1318 1280-3875 124 µM 0.36666040102581 0.369538133969011 no 1235 0.356936173861859 1694 373245
SGTC_959 1222-0044 107 µM 0.364004351529 0.370468558566353 no 1236 0.357927379963172 1822 6083612
SGTC_3149 9097855 49.47 µM 0.363685325774891 0.370580365656744 no 1237 0.35804650119903 1816 25236625 YMR079W SEC14
SGTC_2713 st079149 53.4 µM 0.363128175501727 0.370775653066183 no 1238 0.358254569046473 1696 3103253
SGTC_3032 9089427 49.47 µM 0.361736450083021 0.371263613768077 no 1239 0.358774492902832 1650 17173707
SGTC_2732 terfenadine 20 µM 0.361051264817044 0.371503926537952 no 1240 0.359030562162294 1713 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1137 ixabepilone 100 µM 0.359734081152704 0.371966038658832 no 1241 0.359523001417411 1623 154225 A novel microtubule stabilizer.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.358116120157014 0.372533925986029 no 1242 0.360128207933484 1638 23665772 A membrane-active detergent.
SGTC_533 1222-0222 6.71 µM 0.356433606459078 0.373124764677898 no 1243 0.360757932736175 1799 3982874
SGTC_655 k060-0012 42 µM 0.356302175130975 0.373170931251297 no 1244 0.360807140279179 1666 5994525
SGTC_3196 9111891 49.47 µM 0.356047423938018 0.373260420350181 no 1245 0.360902525016116 1679 18891510
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.355194579304241 0.373560057678483 no 1246 0.361221912702239 1764 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2028 5153890 36.43 µM 0.352887709298279 0.374370933022262 no 1247 0.362086312694653 1676 2830968 YPR165W RHO1
SGTC_3312 9133330 71.43 µM 0.352620879370606 0.374464760903395 no 1248 0.362186341194969 1774 17617324
SGTC_545 4218-0007 221 µM 0.35098797696976 0.375039115279233 no 1249 0.362798684153929 1721 2840508
SGTC_3346 9158254 43.5805 µM 0.349430743457239 0.375587112287022 no 1250 0.363382978116455 1691 17639500
SGTC_261 5-fluorouridine 15.376 µM 0.347271522490135 0.376347366468306 no 1251 0.364193671420456 1780 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3215 9129942 49.47 µM 0.347235472083048 0.376360063772954 no 1252 0.364207211946624 1840 17682944
SGTC_3332 9141069 11.198 µM 0.346981937860365 0.376449364775241 no 1253 0.36430244414021 1651 17332883
SGTC_1954 st077032 68.9 µM 0.346244064041915 0.376709299736243 no 1254 0.364579650994225 1624 698907
SGTC_78 0336-0123 156.75 µM 0.343356824307357 0.377726940256976 no 1255 0.365665018260703 1656 6765896
SGTC_2295 7971645 200 µM 0.34263171453929 0.377982647154534 no 1256 0.365937769988838 1779 2978226 YKL099C UTP11
SGTC_1723 st034307 2.5525 µM 0.342587152228802 0.377998363610152 no 1257 0.365954534417502 1672 867466
SGTC_1713 st033146 12.748 µM 0.339599760553957 0.379052430924135 no 1258 0.367078979239556 1830 674619
SGTC_3261 9137475 49.47 µM 0.339370454006255 0.379133376432936 no 1259 0.367165336781337 1736 17027690
SGTC_561 1550-0330 72.9 µM 0.338464986785882 0.379453059288861 no 1260 0.367506404109827 1689 6812934
SGTC_764 1951-2361 146 µM 0.338391445268524 0.379479027365551 no 1261 0.367534109992088 1655 5438930
SGTC_1947 st076332 61.6 µM 0.337026523664379 0.379961090276597 no 1262 0.36804845280382 1828 24208416
SGTC_2120 5538279 151.968 µM 0.336147916509513 0.380271495438678 no 1263 0.368379663207768 1750 2058197
SGTC_2158 5657123 3.6195 µM 0.333001169209467 0.381383848540311 no 1264 0.36956670028854 1784 2858827
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.332675956260187 0.381498865098022 no 1265 0.369689450428242 1704 115019
SGTC_1031 k035-0009 16 µM 0.332424933512452 0.381587650307669 no 1266 0.369784206898443 1850 5180959
SGTC_1311 1190-0148 100 µM 0.331914227510909 0.38176830312345 no 1267 0.369977013423875 1835 1961333
SGTC_549 1661-1316 519 µM 0.326970619078294 0.383518338974879 no 1268 0.371845053736811 1852 2857282
SGTC_2619 obliquin 87.91 µM 0.322156974791418 0.385224654385513 no 1269 0.373666888708076 1808 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2744 captopril 92.04 µM 0.320852451340022 0.385687459528355 no 1270 0.374161104300886 1866 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1885 st057546 99.9 µM 0.320462446035357 0.385825853156247 no 1271 0.374308897087481 1837 702008
SGTC_353 1988-1175 58.3 µM 0.319161107921582 0.386287738866128 no 1272 0.374802173627291 1690 2788357
SGTC_906 1165-0455 526 µM 0.31871553559056 0.38644592353733 no 1273 0.374971116432302 1701 3252859
SGTC_918 glabranin 770.725 nM 0.317302413196186 0.386947727306511 no 1274 0.375507073219683 1785 124049 Also referred to as licorice root.
SGTC_1299 1079-1439 3.74 µM 0.316906883612869 0.387088214877947 no 1275 0.375657129340982 1706 323161
SGTC_1443 4112-3303 14 µM 0.316727422395297 0.387151962323623 no 1276 0.375725219591442 1744 704433
SGTC_1578 josamycin 24.2 µM 0.316719937209091 0.387154621245567 no 1277 0.375728059666319 1689 5282165 A P450 substrate.
SGTC_3110 9122132 49.47 µM 0.316664995117874 0.387174138187557 no 1278 0.375748906334817 1854 918317
SGTC_582 0987-0078 156 µM 0.316599014451597 0.387197576711958 no 1279 0.375773941847327 1794 1625765
SGTC_859 0439-0102 54.6 µM 0.315938476139757 0.387432244516112 no 1280 0.376024603395961 1880 610143
SGTC_762 1165-0429 115 µM 0.315460083119869 0.387602227705206 no 1281 0.376206176990781 1861 5967793
SGTC_1588 farnesol 29.9 µM 0.315066784686136 0.387741991122665 no 1282 0.376355473547534 1730 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_11 0438-0307 1.3 µM 0.314198430772076 0.388050622813795 no 1283 0.376685167222675 1872 4011476
SGTC_1769 st044406 64.4 µM 0.313218742993523 0.388398909857125 no 1284 0.377057239756842 1752 670903
SGTC_853 0419-0306 21 µM 0.313033599235255 0.388464740074442 no 1285 0.377127567760251 1715 762713
SGTC_2131 toluylene red 5.2905 µM 0.311822876910984 0.388895306689004 no 1286 0.377587568515992 1690 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1391 3442-0225 151 µM 0.310576537937213 0.389338682162456 no 1287 0.3780612828605 1774 5227075
SGTC_1963 st076565 50.3 µM 0.310389950939596 0.389405071462797 no 1288 0.378132217518854 1725 4914280
SGTC_2366 9070441 60.58 µM 0.310337348881899 0.389423788322509 no 1289 0.3781522159516 1698 6837235
SGTC_1508 1080-0625 72.9 µM 0.310321369902521 0.389429474012396 no 1290 0.378158290960053 1785 767111
SGTC_2465 5809242 33.21 µM 0.309321058107735 0.389785455124268 no 1291 0.378538656927675 1816 2731748
SGTC_645 0845-0943 5.41 µM 0.306603871407592 0.390752886727587 no 1292 0.379572453266316 1775 1885106
SGTC_1491 4138-0063 26.5 µM 0.306273287950124 0.390870634488062 no 1293 0.379698287861427 1875 23883227
SGTC_1129 3453-1384 223 µM 0.30596212112922 0.3909814755408 no 1294 0.37981674327211 1790 1084452
SGTC_77 0828-0286 12.516 µM 0.304457553730298 0.391517543827895 no 1295 0.380389662963423 1773 745345
SGTC_1102 cgs 12066b 26.1 µM 0.302554710154145 0.39219581054509 no 1296 0.381114616821738 1798 6438352 A 5-HT1B full agonist.
SGTC_1176 0848-0131 83.3 µM 0.302253059203223 0.392303363871569 no 1297 0.381229579549096 1931 6769040
SGTC_3193 9111931 49.47 µM 0.300776497959114 0.392829948773116 no 1298 0.381792465471403 1775 17087244
SGTC_1036 k216-0215 33.5 µM 0.300173490653861 0.393045055285679 no 1299 0.38202241231178 1726 622330
SGTC_1293 1000-1278 195 µM 0.2990509935295 0.39344556265539 no 1300 0.382450568788679 1856 678847
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.298703430177094 0.393569596267326 no 1301 0.382583169789554 1724 4330530
SGTC_2853 9015042 58.44 µM 0.297446146951195 0.394018368266104 no 1302 0.383062958403427 1707 6457456
SGTC_2753 fluvastatin 17.09 µM 0.296738455365235 0.394271032147499 no 1303 0.383333097747708 1801 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1514 1189-1591 158 µM 0.295863394987201 0.39458351245795 no 1304 0.38366720337956 1860 767698 YMR146C TIF34
SGTC_1609 st001574 46.4 µM 0.294095872526916 0.395214893869446 no 1305 0.384342322372281 1742 3960012
SGTC_818 4072-2707 53.5 µM 0.293368996780531 0.395474623045463 no 1306 0.384620060206178 1733 882871
SGTC_2712 st079126 47.7 µM 0.292734765587625 0.39570128616108 no 1307 0.384862447126698 1779 3152970
SGTC_2229 7354935 190 µM 0.290649984239825 0.39644659867324 no 1308 0.385659513807383 1866 318112
SGTC_2364 9055074 200 µM 0.288230003691413 0.397312220036007 no 1309 0.386585341619616 1743 6470630
SGTC_477 mead ethanolamide 10 µM 0.286879895438919 0.397795370773646 no 1310 0.387102142433782 1811 16061185
SGTC_1912 st060209 90.8 µM 0.286196944154148 0.398039831992373 no 1311 0.387363642058294 1733 688787
SGTC_1946 st076057 65.1 µM 0.285526812595679 0.398279743325671 no 1312 0.387620282742809 1795 953009
SGTC_1020 4335-0961 93.3 µM 0.285236567138231 0.398383664974325 no 1313 0.3877314534674 1715 669075
SGTC_83 0170-0301 39.027 µM 0.285047904350554 0.398451219071542 no 1314 0.387803720615837 1863 3089716
SGTC_2918 7977171 22.06 µM 0.284949310084014 0.398486523729097 no 1315 0.387841488626841 1801 2236483
SGTC_1081 sertraline 6 µM 0.284011066817601 0.398822531626841 no 1316 0.388200949813129 1910 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1481 3346-2004 36 µM 0.283712410232843 0.398929503614195 no 1317 0.388315391692162 1820 2770522
SGTC_209 4077-0173 175.592 µM 0.28057035509625 0.400055374814604 no 1318 0.389519978121913 1840 15993494
SGTC_1048 3161-0300 24.5 µM 0.279824433045476 0.400322778420013 no 1319 0.38980610268772 1783 2165101
SGTC_2481 5478948 45.16 µM 0.279269688657315 0.400521677563857 no 1320 0.390018933091282 1794 77792
SGTC_2797 7859098 81.82 µM 0.278804615956449 0.400688445527006 no 1321 0.39019738592539 1788 972681
SGTC_1377 2944-0135 198 µM 0.276882597047453 0.401377843816866 no 1322 0.390935127960509 1824 1894137
SGTC_272 doxorubicin 8.13 µM 0.276059478285184 0.401673177767237 no 1323 0.391251191673847 1853 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1021 4476-0760 85.3 µM 0.274419823565508 0.402261650992543 no 1324 0.391881005267435 1749 746768
SGTC_2356 9061756 188.97 µM 0.271601754908726 0.403273574824315 no 1325 0.39296412497139 1949 20104043
SGTC_3176 9106582 49.47 µM 0.271568695092874 0.403285449939583 no 1326 0.39297683639037 1940 17018027
SGTC_1235 benzylparaben 21.5 µM 0.269705000395325 0.403955034646471 no 1327 0.3936936066526 1845 7180
SGTC_3279 9140807 49.47 µM 0.268900452500868 0.404244178207704 no 1328 0.39400314437313 1834 45595718
SGTC_2920 7982904 15.77 µM 0.267718343331237 0.404669107013688 no 1329 0.394458064564532 1811 6456808
SGTC_3250 9135583 49.47 µM 0.26752657715395 0.404738051170574 no 1330 0.394531877011685 1928 7699353
SGTC_86 0417-1630 471.922 µM 0.267010736365886 0.40492352194715 no 1331 0.394730447344065 1953 3634867
SGTC_1117 retinoic acid 1.10837 µM 0.265751813766329 0.405376257703725 no 1332 0.395215178038751 1967 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2414 st077232 92.9 µM 0.26493367659351 0.405670545430139 no 1333 0.395530277415286 1720 729801
SGTC_2344 7990960 76.95 µM 0.26474026201674 0.405740125347621 no 1334 0.395604779574408 1816 140813
SGTC_698 k064-0052 127 µM 0.263647089342852 0.406133444620835 no 1335 0.396025934907835 1887 5088751
SGTC_2662 daunorubicin 22.37 µM 0.26304530045877 0.406350006382298 no 1336 0.396257831729022 1843 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2023 5144124 124 µM 0.262606207881288 0.406508037789639 no 1337 0.396427057381196 1825 2830192
SGTC_1088 bifonazole 369 nM 0.262311226333686 0.406614211537987 no 1338 0.396540753808509 1891 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2464 5717415 7.67 µM 0.261523845945721 0.406897649737099 no 1339 0.396844281399501 1767 5285744
SGTC_2511 berberine 10.47 µM 0.261478551112873 0.406913956283778 no 1340 0.396861744026359 1810 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1302 1159-0335 255 µM 0.260691858992157 0.407197198231044 no 1341 0.397165072310886 1812 649284
SGTC_2173 5763948 167 µM 0.260642411351936 0.40721500306492 no 1342 0.39718414013142 1926 2867177
SGTC_1001 4048-4355 44.4 µM 0.257462970423081 0.40836023956075 no 1343 0.398410698653565 1829 21824233
SGTC_144 4161-2749 112.381 µM 0.256328159468233 0.408769189290012 no 1344 0.398848727648852 1898 797501 YMR168C CEP3
SGTC_300 r073-0011 5.04 µM 0.251379545154562 0.410553667903384 no 1345 0.400760340334376 1994 2735780
SGTC_472 calcifediol 10 µM 0.250276261200115 0.410951767898201 no 1346 0.401186856609182 1882 5283731 A vitamin D metabolite.
SGTC_1153 4055-0057 267 µM 0.249524276155388 0.411223160652722 no 1347 0.401477632492197 1812 882706
SGTC_1853 st056710 91.2 µM 0.248669277879283 0.411531782683218 no 1348 0.401808307581094 2019 269167
SGTC_3172 9105863 49.47 µM 0.248181087481031 0.411708025513436 no 1349 0.401997149340377 1918 2348785
SGTC_2558 carylophyllene oxide 100 µM 0.247278786801442 0.412033814191489 no 1350 0.402346237391635 1910 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2935 9038016 29.96 µM 0.246116444767995 0.412453583891512 no 1351 0.402796046729853 1996 6463195
SGTC_795 0685-0265 78 µM 0.246086497134507 0.41246440054404 no 1352 0.402807637728357 1848 302754
SGTC_817 1391-0715 46 µM 0.244377539764791 0.413081761152902 no 1353 0.403469217599817 1827 1353946
SGTC_2591 skatole 100 µM 0.243817513380017 0.413284117453317 no 1354 0.403686077939748 1866 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1348 1493-0373 93.8 µM 0.243640263328412 0.413348168639192 no 1355 0.403754721068528 1913 3010129
SGTC_747 3448-8087 38.7 µM 0.243466916050813 0.413410811746883 no 1356 0.403821855648259 1832 5168703
SGTC_1092 toremifene 6.32 µM 0.243252661230685 0.413488240800939 no 1357 0.403904836968617 1967 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2843 9000894 45.46 µM 0.243099728320598 0.413543510929674 no 1358 0.403964070836095 1879 2242070
SGTC_1466 k213-0079 57.5 µM 0.242888942108235 0.413619692115555 no 1359 0.404045716013208 1876 3657981
SGTC_142 0335-0849 62.6745 µM 0.241339496106873 0.414179783928314 no 1360 0.404646000959296 1900 3889043 YPR107C YTH1
SGTC_1297 1068-0111 14.1 µM 0.240131374997039 0.414616615236858 no 1361 0.405114205973481 1818 767057
SGTC_3315 9136395 68.55 µM 0.24009259279268 0.414630639822759 no 1362 0.405129238196153 2022 16876844
SGTC_1122 capsaicin 818.572 nM 0.239972123106115 0.41467420527782 no 1363 0.405175933885598 1934 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_546 peri-Naphthalide 147 µM 0.238621119902657 0.415162840352832 no 1364 0.405699693416083 1950 223824 A penicillin ester.
SGTC_880 0833-0487 87.2 µM 0.2385941574839 0.415172593543383 no 1365 0.40571014798043 1835 76075
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.236792513628577 0.415824425334525 no 1366 0.406408879836864 1838 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_980 1473-0395 201 µM 0.235964304789268 0.416124147765595 no 1367 0.406730184380557 1838 768876
SGTC_2159 5658611 73.75 µM 0.232564674492704 0.417354957227862 no 1368 0.40804973043 1990 793844
SGTC_2778 tioconazole 65.09 nM 0.232041443286193 0.417544461227984 no 1369 0.408252912514352 1893 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3011 9081274 71.4286 µM 0.230430240323929 0.418128127197204 no 1370 0.408878732469191 1868 6625322
SGTC_923 1900-2434 73.3 µM 0.230414564445443 0.418133806747006 no 1371 0.408884822403858 1834 5910570
SGTC_3262 9137218 49.47 µM 0.229958871124296 0.418298917098069 no 1372 0.409061864677464 1931 17650664
SGTC_12 0849-0099 9.267 µM 0.227288706981532 0.419266680190007 no 1373 0.410099626929266 2003 6071388
SGTC_3112 9123419 49.47 µM 0.227245825128161 0.419282226111151 no 1374 0.410116298167942 2021 17015854
SGTC_1666 st014829 29 µM 0.226740914758038 0.419465280300228 no 1375 0.410312605095306 1883 3858230
SGTC_2321 7390090 138.78 µM 0.225719674027398 0.41983558221416 no 1376 0.410709727644882 1832 649046
SGTC_310 1273-0058 1.06 µM 0.225593758911252 0.419881243960827 no 1377 0.410758697699834 1967 2734232
SGTC_2694 st077685 81.9 µM 0.225196933240484 0.42002515552529 no 1378 0.410913037551099 1856 2838096
SGTC_2568 diosmetin 100 µM 0.223372069977172 0.42068709214191 no 1379 0.411622970058265 2059 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_999 SEC7.066 22.7 µM 0.222229191858987 0.421101765163261 no 1380 0.412067735203509 1934 740511 YDR170C SEC7
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.221650295128495 0.421311840987037 no 1381 0.412293063161478 1888 6857784
SGTC_1384 3089-0840 101 µM 0.219879463910419 0.421954596723784 no 1382 0.412982515180374 2015 1069836
SGTC_882 0843-0131 351 µM 0.219306812330161 0.422162495718563 no 1383 0.413205527797752 2043 5425421
SGTC_2956 9076196 2.52 µM 0.218057604016366 0.422616091273442 no 1384 0.413692114806255 2032 16423868
SGTC_285 1486-1325 46 µM 0.216289989207946 0.423258098774229 no 1385 0.414380855924354 2012 22310230
SGTC_1702 st027038 51 µM 0.216148688064006 0.423309428953609 no 1386 0.414435924511662 1953 5521182
SGTC_2330 7979373 200 µM 0.215922838843775 0.423391475443476 no 1387 0.414523947089572 1804 1863007
SGTC_356 1634-0012 32.5 µM 0.215421472323175 0.423573623707746 no 1388 0.414719365241025 2081 735457
SGTC_2690 usnic acid 100 µM 0.215383966611809 0.423587250324964 no 1389 0.414733984730373 2017 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3294 9122953 26.2835 µM 0.215044143418573 0.423710719432677 no 1390 0.414866451044478 1944 16459826
SGTC_185 k048-0037 25.491 µM 0.214857406449249 0.42377857039564 no 1391 0.41493924701423 2041 6827589
SGTC_695 3505-6186 243 µM 0.214679643243768 0.423843162836992 no 1392 0.415008547440985 1959 1819379
SGTC_387 norethindrone acetate 66.7 µM 0.214215517616635 0.424011818218252 no 1393 0.415189497819091 1884 541197
SGTC_2556 citropten 84.59 µM 0.213162926913682 0.424394363356911 no 1394 0.41559994186864 1839 2775 A potential DNA crosslinker.
SGTC_3301 9125354 19.7965 µM 0.212938674978855 0.424475872901792 no 1395 0.415687397909049 1889 41905162
SGTC_3206 9114350 49.47 µM 0.212096461020341 0.424782023832785 no 1396 0.416015890298369 2036 17087243
SGTC_1511 0906-3109 28.5 µM 0.212047560390373 0.424799800964872 no 1397 0.416034965029411 2005 2882180
SGTC_929 2805-0021 398 µM 0.211698951229984 0.424926537321848 no 1398 0.416170953177303 1926 3098024
SGTC_2084 5306078 60.6385 µM 0.211372126447504 0.425045361047753 no 1399 0.416298452622646 1975 679340
SGTC_3037 9091026 49.47 µM 0.210003725711618 0.425542944496209 no 1400 0.416832382589429 2000 25236398 YIL048W NEO1
SGTC_188 3229-0966 278.469 µM 0.209501471438329 0.425725606037854 no 1401 0.417028393415428 2041 5722370
SGTC_1719 st032227 49.2 µM 0.209294056757597 0.425801043966966 no 1402 0.417109345532385 1869 3125804
SGTC_2582 agaric acid 100 µM 0.208053970562871 0.42625212711335 no 1403 0.417593413415659 1898 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2482 5981709 142.65 µM 0.207993775981009 0.426274025440025 no 1404 0.41761691356666 1959 877755
SGTC_411 enrofloxacin 100 µM 0.207327742296502 0.426516338537697 no 1405 0.417876954797934 2084 71188 A bacterial gyrase inhibitor.
SGTC_1921 5740136 50 µM 0.206549995326349 0.426799329716167 no 1406 0.41818065797557 2076 1774243
SGTC_1967 st070177 51.4 µM 0.204630535816104 0.427497905629175 no 1407 0.418930398036802 2019 5729214
SGTC_1248 0469-0687 58.6 µM 0.204567394001991 0.427520889592965 no 1408 0.418955066220718 1975 4017482
SGTC_610 4215-0184 155 µM 0.204372922917839 0.42759167967055 no 1409 0.419031044000545 1976 5605015
SGTC_911 3456-4043 236 µM 0.204072837321168 0.427700919417434 no 1410 0.419148290168841 1996 914281
SGTC_3177 9107506 49.47 µM 0.203967135905843 0.427739399078617 no 1411 0.419189590382433 2056 8897194
SGTC_136 0097-0015 404.482 µM 0.202433782498909 0.428297679885403 no 1412 0.41978881022381 2077 4861337
SGTC_1561 5-methoxyflavone 52.9 µM 0.20164047290368 0.428586573508209 no 1413 0.420098901128903 2052 94525
SGTC_1652 st011932 78 µM 0.200092727753749 0.429150314316563 no 1414 0.42070403038655 2031 1551076
SGTC_2975 9084847 53.72 µM 0.19974789440728 0.429275933942075 no 1415 0.420838877095397 1891 27211724
SGTC_3350 9150499 3.57 µM 0.199315757880092 0.429433367426553 no 1416 0.421007876730873 1991 4910996 YPR165W RHO1
SGTC_1531 st059297 52.4 µM 0.198692210674193 0.429660554320633 no 1417 0.421251758762577 1982 7566702
SGTC_2029 5175081 200 µM 0.198236294392373 0.429826680315595 no 1418 0.421430096049718 1996 1380876
SGTC_1999 st074831 12.5 µM 0.197578752739677 0.430066296093689 no 1419 0.421687329970291 1929 17112523
SGTC_650 1328-0195 38 µM 0.19725393255261 0.430184673834817 no 1420 0.421814413758049 2059 2780821
SGTC_2447 5741742 33.78 µM 0.196317205068427 0.430526090691157 no 1421 0.422180947855703 1996 1776504
SGTC_1058 3448-5425 97.3 µM 0.196185202310949 0.430574207015115 no 1422 0.422232604922703 2057 7279705
SGTC_2858 9025781 8.96 µM 0.195754052384832 0.430731372648539 no 1423 0.422401337536983 2055 4894980 YPL153C RAD53
SGTC_1540 guanosine 70.6 µM 0.195713308735077 0.430746225362025 no 1424 0.422417283498858 2060 6802 Guanosine is a purine nucleoside
SGTC_1790 st045711 43.5 µM 0.195106833619848 0.430967321719049 no 1425 0.422654656465128 2084 585119
SGTC_1808 st050063 61.5 µM 0.194183128301786 0.43130410895886 no 1426 0.423016246546828 2055 4011993
SGTC_3204 9114183 49.47 µM 0.19351826782738 0.431546551099548 no 1427 0.423276550398312 1886 17027248
SGTC_1227 3909-8010 46.6 µM 0.193503420400189 0.431551965525763 no 1428 0.42328236379391 1975 15982272
SGTC_3334 9142812 21.919 µM 0.191202210120407 0.43239130503736 no 1429 0.424183586067436 2012 45283678
SGTC_1259 0671-0132 43 µM 0.191100169839851 0.432428530129628 no 1430 0.424223557288445 1926 X1259
SGTC_976 1348-1067 47.6 µM 0.190229201877436 0.432746290428861 no 1431 0.424564764557156 1998 5310671 YGL099W LSG1
SGTC_1353 1498-1206 8.11 µM 0.189063085787623 0.433171799401896 no 1432 0.425021686469724 1980 6756808
SGTC_367 0335-0881 7.1 µM 0.188780350156692 0.433274979677629 no 1433 0.42513248661113 2031 23828853
SGTC_539 4859-0462 2.54 µM 0.188694512982465 0.433306305612171 no 1434 0.425166126170484 2096 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1419 3993-2473 62.6 µM 0.186974178949626 0.433934222756347 no 1435 0.425840439061484 2000 704026
SGTC_3287 9117173 37.0625 µM 0.186385145313793 0.434149256799293 no 1436 0.426071370322162 2121 2789709
SGTC_475 α-linolenic acid 10 µM 0.184967590589345 0.434666832513836 no 1437 0.426627227935489 2083 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1193 1488-0126 41.5 µM 0.184828185168829 0.434717738099882 no 1438 0.426681900074266 1988 1384710
SGTC_3062 9077494 49.47 µM 0.184463766704597 0.434850815047829 no 1439 0.426824824675566 2037 16459633
SGTC_1192 1488-0095 21.4 µM 0.18442929952202 0.434863402024684 no 1440 0.426838343171902 1984 915875
SGTC_137 0438-0332 85.389 µM 0.184244057392257 0.434931051225747 no 1441 0.426910999118456 2059 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2840 9008771 71.43 µM 0.181080315169132 0.43608672143784 no 1442 0.428152267693761 2099 2992978
SGTC_2133 5320837 200 µM 0.180313401953535 0.436366946547541 no 1443 0.428453267437341 2051 2841355
SGTC_2914 7968218 45.32 µM 0.180027882719687 0.436471281588633 no 1444 0.428565339281254 2053 2977111
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.179802234745974 0.436553741474799 no 1445 0.428653914568792 1913 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2551 apiole 73.87 µM 0.179535749613813 0.43665112827814 no 1446 0.428758524599546 2072 10659 A possible DNA adduct former.
SGTC_1429 4049-0205 9.46 µM 0.176328091511303 0.437823664260522 no 1447 0.430018096970567 2078 22774478
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.173871455413295 0.43872203951269 no 1448 0.430983243091956 2092 688801
SGTC_1654 st012436 41.8 µM 0.17381468448666 0.438742804008674 no 1449 0.431005551755436 2088 4323132
SGTC_1231 0242-0792 125 µM 0.172963324756045 0.439054216963049 no 1450 0.431340127842401 1951 3707635
SGTC_2318 6029776 164 µM 0.172530076125146 0.439212706462961 no 1451 0.431510409268589 2036 818325
SGTC_1027 k015-0025 8.67 µM 0.172189900030599 0.439337155324005 no 1452 0.431644118949346 1988 3598955
SGTC_1041 0206-0046 107 µM 0.171959480798391 0.439421454516098 no 1453 0.431734692027074 1997 50494
SGTC_1051 3253-3903 78 µM 0.171322531207484 0.439654497679005 no 1454 0.431985082514803 2069 5509239
SGTC_1833 st055984 71 µM 0.171059014406128 0.439750917690923 no 1455 0.432088681284252 1974 676288
SGTC_2826 7992541 19.48 µM 0.171058209733314 0.439751212123782 no 1456 0.432088997639788 2114 2985066
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.170156591491074 0.440081138585628 no 1457 0.432443494392963 2006 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_608 k048-0125 159 µM 0.169663070797766 0.440261748770732 no 1458 0.432637559085722 2100 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1750 st081859 2.357 µM 0.169296997796533 0.440395725881125 no 1459 0.432781518654934 2005 5291695
SGTC_1344 1488-0097 29.1 µM 0.167822437414223 0.440935461342807 no 1460 0.433361485169305 2036 747966
SGTC_2241 6772625 37.8075 µM 0.167783043133029 0.440949882397726 no 1461 0.433376981499671 2165 2285411
SGTC_1867 st057372 64 µM 0.167535054642183 0.441040665281352 no 1462 0.433474533836617 2110 688837
SGTC_1115 galangin 695.678 nM 0.166645931987358 0.441366178073248 no 1463 0.433824325249532 2104 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1759 st043059 70 µM 0.166535992655246 0.441406430235625 no 1464 0.433867580294764 1960 669426
SGTC_1243 0416-0003 5.65 µM 0.164939994703972 0.441990842007347 no 1465 0.434495606137609 1986 2141977
SGTC_237 nikkomycin 200 µM 0.164275350501381 0.442234254260816 no 1466 0.434757192757148 2115 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_766 1391-0721 126 µM 0.162734911214568 0.442798492135634 no 1467 0.435363579100105 2098 1020919 YIL115C NUP159
SGTC_1396 3511-0007 98.6 µM 0.161323966439138 0.443315400117693 no 1468 0.435919123997377 2002 X1396
SGTC_2166 5933061 31.504 µM 0.159770964392558 0.443884463128721 no 1469 0.436530748640145 2076 2877375
SGTC_66 0109-0187 42.4 µM 0.158818592231818 0.444233496014936 no 1470 0.43690590012361 2092 759417
SGTC_1798 st045719 60.953 µM 0.157472535384796 0.444726883288336 no 1471 0.437436225707345 2114 3980186
SGTC_45 0kpi-0036 14.9 µM 0.157112001801907 0.444859048805476 no 1472 0.437578289491571 2033 2795021
SGTC_1732 st034308 51.822 µM 0.157048369793524 0.444882375860999 no 1473 0.437603363730822 1912 830119
SGTC_661 1304-0007 33.6 µM 0.156900318045642 0.44493665134951 no 1474 0.43766170459949 1996 3117130
SGTC_1271 0832-2808 169 µM 0.1553671793635 0.445498757577656 no 1475 0.438265928506871 2126 3663794
SGTC_699 0375-0592 111 µM 0.15354525299861 0.446166886615899 no 1476 0.438984153321971 2196 762578
SGTC_1134 3477-0009 42.5 µM 0.153236017449459 0.446280303380691 no 1477 0.439106077626916 2164 3973534
SGTC_1263 0774-1208 64.8 µM 0.152828114994288 0.446429914430399 no 1478 0.439266912807692 2152 906585
SGTC_2466 5983409 37.09 µM 0.152371067655636 0.446597559969871 no 1479 0.439447137634959 2023 2879657
SGTC_1733 st037357 54.9 µM 0.150480847696172 0.447290996068519 no 1480 0.440192630000149 1992 1272339 YGL099W LSG1
SGTC_2249 haloperidol 116.36 µM 0.149157719076607 0.447776488050143 no 1481 0.44071459099582 2039 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_594 1487-1584 10.8 µM 0.146965483244467 0.448581051051579 no 1482 0.44157963240875 1997 5013332
SGTC_1301 naphtanilide LB 4.81 µM 0.146036689004452 0.448921987797357 no 1483 0.441946212627889 2143 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2973 9094665 17.96 µM 0.145463744592969 0.449132319947671 no 1484 0.442172369433642 2141 25237061 YIL048W NEO1
SGTC_2470 5664817 21.68 µM 0.144921152930685 0.4493315225586 no 1485 0.442386562559445 2185 2859561
SGTC_2801 7907800 81.82 µM 0.144878411026261 0.449347215010829 no 1486 0.44240343604184 2029 6620925
SGTC_2151 5563267 85.4165 µM 0.144262090243448 0.449573502550123 no 1487 0.442646756358758 2028 5310824
SGTC_704 1310-0270 142 µM 0.143876052806152 0.449715247912694 no 1488 0.442799173005001 2014 5718033
SGTC_260 nsc-65238 3.989 µM 0.143722391723182 0.449771671029676 no 1489 0.442859844366024 2129 3246252
SGTC_2564 betulinic acid 100 µM 0.143165287535047 0.449976243724807 no 1490 0.443079821952456 2194 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_507 nimesulide 162 µM 0.140225249958783 0.451056065758499 no 1491 0.444241011209568 2146 4495 A COX2 inhibitor.
SGTC_2927 9011802 47.9 µM 0.140215115247213 0.451059788683918 no 1492 0.444245014821504 2004 43912568
SGTC_3066 9117245 49.47 µM 0.140174578186339 0.451074679772781 no 1493 0.444261028620826 2095 17176980
SGTC_1928 4'-methoxychalcone 40.3 µM 0.139511700293031 0.451318194443102 no 1494 0.4445229054295 2198 641818
SGTC_511 blebbistatin 171 µM 0.137482834588244 0.452063631548849 no 1495 0.44532457995888 2152 3476986 A myosin inhibitor.
SGTC_869 0564-0080 44.1 µM 0.136848599537796 0.452296694262931 no 1496 0.445575234048878 1987 6843321
SGTC_496 calpeptin 138 µM 0.136538604768276 0.452410614202697 no 1497 0.445697754053202 2049 73364 A calpain inhibitor.
SGTC_2160 5660466 132.927 µM 0.136146318659476 0.45255478099133 no 1498 0.445852805700535 2172 2859134
SGTC_3138 9097216 49.47 µM 0.134371562445204 0.453207089223521 no 1499 0.446554383779248 2224 25237486
SGTC_476 mead acid 10 µM 0.13406222434204 0.45332079882126 no 1500 0.446676685270908 2075 5312531 An omega 9 fatty acid.
SGTC_2757 clomiphene 4.22 µM 0.133762717798595 0.453430898082694 no 1501 0.446795104539819 2185 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_887 0885-0007 9.62 µM 0.133259442119348 0.453615911381427 no 1502 0.446994100981235 2147 5719458
SGTC_392 N-ethylmaleimide 8.33 µM 0.133017436012322 0.453704880817437 no 1503 0.44708979554615 2066 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_141 0443-0274 32.331 µM 0.131903520872062 0.454114422695091 no 1504 0.447530301855621 2176 1627241
SGTC_732 3970-1727 52.7 µM 0.131888822008392 0.454119827204279 no 1505 0.447536115068192 2177 1275699
SGTC_802 4112-3352 742 µM 0.131311840300099 0.454331979756881 no 1506 0.447764312844796 2142 704594
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.12826922052879 0.455450946051214 no 1507 0.448967961160779 2179 165521
SGTC_1768 st044301 37.178 µM 0.127633503950625 0.455684784722205 no 1508 0.449219507822719 2084 3931349
SGTC_56 0957-0365 83.25 µM 0.126543546347015 0.456085744725309 no 1509 0.449650840536566 2184 6752360
SGTC_833 3852-0053 558 µM 0.123427024107094 0.457232457427522 no 1510 0.450884479268832 2137 3123681
SGTC_2199 6590217 200 µM 0.122616657203457 0.457530687631518 no 1511 0.45120533172064 2149 703109
SGTC_2899 9053889 58.44 µM 0.120151697984809 0.458437985124765 no 1512 0.452181489956574 2223 6470052
SGTC_754 3474-0146 171 µM 0.120108063842094 0.458454047861657 no 1513 0.452198772307555 1987 24762078
SGTC_584 0986-0246 15.4 µM 0.117400876156407 0.459450757888917 no 1514 0.453271194901087 2219 53315 YDR232W HEM1
SGTC_1774 st048371 48.465 µM 0.11688575257052 0.459640440899654 no 1515 0.453475294279093 2148 4242727
SGTC_177 1327-0068 8.361 µM 0.116679823790912 0.459716272248318 no 1516 0.453556889666557 2207 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2252 omeprazole 400 µM 0.115891499028571 0.460006578994213 no 1517 0.453869266545334 2141 4594 A proton pump inhibitor.
SGTC_3156 9099931 49.47 µM 0.115445427014111 0.460170857950695 no 1518 0.454046037043081 2121 18111053
SGTC_2208 7283366 200 µM 0.114214671007457 0.46062415471997 no 1519 0.454533811116108 2185 898663
SGTC_2302 7771753 200 µM 0.114150930372808 0.460647632277842 no 1520 0.454559074722471 2080 2203047
SGTC_2191 5911152 200 µM 0.113192644726984 0.46100061366562 no 1521 0.454938913424335 2201 2875902
SGTC_1362 1611-0397 101 µM 0.11162704226928 0.461577364204743 no 1522 0.455559564696317 2149 27816
SGTC_3051 9093778 49.47 µM 0.109264399874147 0.462447888011356 no 1523 0.456496391139495 2219 17217378
SGTC_2329 6138490 200 µM 0.107628847293736 0.463050618672123 no 1524 0.457145056536975 2072 720019
SGTC_2308 7584454 197.62 µM 0.107603776542304 0.463059858360453 no 1525 0.45715500057041 2185 893577
SGTC_2035 5154463 94.595 µM 0.107518330680151 0.463091349115326 no 1526 0.457188891918409 2191 2769623
SGTC_1388 3346-4487 254 µM 0.107217407243134 0.463202255169775 no 1527 0.457308253024559 2152 3345614
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.10699784652494 0.463283176604282 no 1528 0.457395344086277 2207 165506
SGTC_2008 4012253 172 µM 0.106599396924387 0.463430033314272 no 1529 0.457553398522192 2159 603940
SGTC_2996 9066192 71.4286 µM 0.102217585267743 0.46504536356484 no 1530 0.459291984920213 2116 6472854
SGTC_2600 tangeritin 87.95 µM 0.101556279417921 0.465289200946877 no 1531 0.459554441961357 2189 68077 A bioactive flavone.
SGTC_1264 0783-0040 158 µM 0.101039420241688 0.465479786879743 no 1532 0.459759583726946 2132 2855798
SGTC_1158 4092-0494 91.8 µM 0.101036373135174 0.465480910489077 no 1533 0.459760793157455 2173 1148199
SGTC_1450 4112-4260 37.6 µM 0.100833470354196 0.46555573076304 no 1534 0.459841328368154 2224 1633175
SGTC_2670 beta-carotene 100 µM 0.100274406976601 0.465761891326315 no 1535 0.460063237670427 2226 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_376 3970-0862 59.1 µM 0.100075904013102 0.465835093617533 no 1536 0.460142032545986 2230 3135186
SGTC_2215 7188065 200 µM 0.0993565507449499 0.46610038046969 no 1537 0.460427589743938 2212 940217
SGTC_2644 guaiazulene 100 µM 0.0991049006024177 0.466193188885043 no 1538 0.460527490564089 2216 3515 A coloring agent.
SGTC_2146 5545642 200 µM 0.0986490907419883 0.466361295954071 no 1539 0.460708445653902 2210 825326
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0976773325660671 0.46671970973304 no 1540 0.461094257730634 2114 688667
SGTC_1989 st071868 50.2 µM 0.0974554902261306 0.46680153568582 no 1541 0.461182339784608 2256 16414057
SGTC_478 N-arachidonylglycine 10 µM 0.0974151902096268 0.466816400389645 no 1542 0.461198341029459 2237 5283389
SGTC_412 gemfibrozil 100 µM 0.0955119797831726 0.467518453917365 no 1543 0.461954087635661 2234 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2913 7966556 36.57 µM 0.0948519702935357 0.467761940978237 no 1544 0.462216203295935 2229 2976516
SGTC_2109 5483026 200 µM 0.0947292707495282 0.467807207949647 no 1545 0.462264933910612 2154 759335
SGTC_680 0417-1641 114 µM 0.0942112583826285 0.467998320421714 no 1546 0.462470670828828 2148 2835990
SGTC_1975 st070967 30.8 µM 0.0938733118632822 0.468123004424848 no 1547 0.462604897123602 2253 261391
SGTC_2285 7945142 200 µM 0.0934115851876665 0.46829336166912 no 1548 0.4627882935563 2161 2970608
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0904446945979368 0.469388153614218 no 1549 0.463966920526699 2212 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_722 3534-0461 190 µM 0.0902910651750541 0.469444849728496 no 1550 0.464027960054226 2152 658262
SGTC_2891 9063876 19.48 µM 0.0902815223802449 0.469448371466171 no 1551 0.464031751593429 2276 6472478
SGTC_2746 daunorubicin 9.88 µM 0.0890312498020984 0.469909801100536 no 1552 0.4645285374879 2244 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2054 5233173 129 µM 0.0887605431264733 0.470009714323638 no 1553 0.46463610794852 2183 6889
SGTC_2325 6158266 200 µM 0.0884872866763582 0.470110570540041 no 1554 0.464744694232014 2161 3623240
SGTC_1212 0520-0165 585 µM 0.0871315908670651 0.470610972502438 no 1555 0.465283457493252 2267 5403258
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0861846005487495 0.470960544434082 no 1556 0.465659836068731 2126 688803
SGTC_394 menadione 8.33 µM 0.0857601855826662 0.471117220219066 no 1557 0.465828528564081 2264 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2541 muurolladie-3-one 83.07 µM 0.0854989951294094 0.471213642744981 no 1558 0.465932347159134 2220 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0854640311295207 0.47122655037857 no 1559 0.465946244908067 2167 803109
SGTC_1812 st052057 4.327 µM 0.0842080514599771 0.471690239390248 no 1560 0.46644550839425 2240 3645418
SGTC_2051 5263410 176 µM 0.0839915921894308 0.471770156827525 no 1561 0.466531558304338 2282 227584
SGTC_726 3448-4391 34.2 µM 0.0826123020424779 0.472279421610734 no 1562 0.467079909549761 2208 1356692
SGTC_2061 5245884 80.95 µM 0.0812866019570672 0.472768942469056 no 1563 0.467607014409165 2235 573863
SGTC_2611 pyromycin 23.93 µM 0.0805671663684222 0.473034614635947 no 1564 0.467893089366486 2186 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1924 st058459 75.1 µM 0.0799984878883988 0.473244623923151 no 1565 0.468119229304 2287 688683
SGTC_1637 st007924 17.4 µM 0.0798482545623087 0.473300105363715 no 1566 0.46817897261209 2257 683336
SGTC_3322 9139058 2.11 µM 0.0795408097845263 0.473413646892708 no 1567 0.468301236453036 2216 4908926 YPR165W RHO1
SGTC_390 dec-rvkr-cmk 16.7 µM 0.0773210663725133 0.474233477349082 no 1568 0.469184066266015 2205 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_936 3005-4620 401 µM 0.0760101469016747 0.474717698169809 no 1569 0.469705512747047 2282 777207
SGTC_186 3455-3465 67.277 µM 0.0757527116605309 0.474812792710351 no 1570 0.469807919296101 2275 755278
SGTC_2948 9070189 9.45 µM 0.0753650393001612 0.474955998517693 no 1571 0.469962137335234 2275 6473636 YDL196W YDL196W
SGTC_2291 7917025 104.35 µM 0.0736449017658911 0.475591454488431 no 1572 0.470646470838913 2224 2964612
SGTC_1412 3909-8563 178 µM 0.0734296517474004 0.475670976900036 no 1573 0.470732111298358 2277 23767530
SGTC_2810 7959871 45.46 µM 0.0730088849171877 0.475826428663048 no 1574 0.470899523620046 2227 2974535
SGTC_2946 9065502 71.43 µM 0.0726134048457353 0.475972541620503 no 1575 0.471056879678624 2291 16489101
SGTC_1854 st056233 32.9 µM 0.0719488070970105 0.47621808930668 no 1576 0.471321324109455 2285 5393174
SGTC_231 b-estradiol 524 µM 0.0719145204354711 0.476230757381114 no 1577 0.47133496716699 2245 450 A steroid.
SGTC_1944 st076371 56.9 µM 0.0716020820987199 0.476346196733514 no 1578 0.471459291527782 2152 24208455
SGTC_366 0181-0206 4.31 µM 0.0712154150724744 0.476489064763263 no 1579 0.47161315655651 2283 274874
SGTC_2940 9060638 45.86 µM 0.0705347803336352 0.476740557060728 no 1580 0.471884009386367 2182 4027022
SGTC_681 1642-0006 26.6 µM 0.0700028304451167 0.476937117249996 no 1581 0.472095703398476 2294 4446530
SGTC_2155 5570423 76 µM 0.0695400133256365 0.477108136836094 no 1582 0.472279891848425 2191 797402
SGTC_225 nsc-122657 1.016 µM 0.0688345042665159 0.477368843736825 no 1583 0.472560676390118 2249 275685
SGTC_971 1315-0384 26.7 µM 0.0684842955928901 0.477498260020819 no 1584 0.47270006051252 2208 6769120
SGTC_3088 9117578 49.47 µM 0.0677075553457868 0.477785305439072 no 1585 0.473009217409857 2284 678341
SGTC_219 mitoxanthrone 164.414 µM 0.0657741488150293 0.478499848186765 no 1586 0.47377881895645 2260 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_589 1227-0070 34.1 µM 0.0656240339005298 0.478555330140002 no 1587 0.473838577034431 2237 2841384
SGTC_2406 ethylparaben 405.7 µM 0.0649393890784924 0.478808377752058 no 1588 0.474111129408005 1998 8434 A possible steroid mimic.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0644237359109089 0.478998970981688 no 1589 0.474316415378921 2266 688751
SGTC_71 0417-1750 47.813 µM 0.0642298586901561 0.479070632186825 no 1590 0.474393601338735 2296 6811472
SGTC_1661 st013063 9.66 µM 0.0640338664529741 0.479143075835343 no 1591 0.474471630301053 2286 721395
SGTC_1878 temozolomide 1 mM 0.062516177125079 0.479704075035157 no 1592 0.475075889827498 2303 5394 DNA alkylating agent.
SGTC_719 2810-4230 27.3 µM 0.0617930184652188 0.47997139785957 no 1593 0.475363831660995 2307 721079
SGTC_3139 9095020 49.47 µM 0.0612717563389246 0.480164093206867 no 1594 0.47557139185203 2311 25236292
SGTC_1148 3909-7663 27.7 µM 0.0611791490428592 0.480198327899214 no 1595 0.475608267637605 2299 4084526
SGTC_3150 9097574 49.47 µM 0.0601153424659173 0.480591602043957 no 1596 0.476031885271028 2282 17217476
SGTC_2648 atorvastatin 78.68 µM 0.0594333783112444 0.48084372444313 no 1597 0.476303463995276 2297 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2110 5483698 200 µM 0.0590683574111559 0.480978675959226 no 1598 0.476448830873432 2232 2848765 YHR062C RPP1
SGTC_864 0469-0573 172 µM 0.0576573409559446 0.481500361819484 no 1599 0.477010787059946 2211 689425
SGTC_2268 7933382 153.85 µM 0.0574379789497079 0.481581467963539 no 1600 0.477098155049196 2315 935025 YOR257W CDC31
SGTC_3167 9103034 49.47 µM 0.0566993935288235 0.481854555549521 no 1601 0.477392328567054 2296 5127859
SGTC_3352 9151559 45.5865 µM 0.0554866781515631 0.482302968287845 no 1602 0.477875371447519 2259 17159339
SGTC_2021 4019055 173 µM 0.0550988135001305 0.482446389586151 no 1603 0.478029870700141 2284 44827708 YER133W GLC7
SGTC_2834 9001755 58.44 µM 0.0544303672692521 0.482693567279623 no 1604 0.478296142563317 2180 2989575
SGTC_1339 1486-1321 22.7 µM 0.0541002394556791 0.482815644227639 no 1605 0.478427650735297 2208 3469382
SGTC_344 k064-0035 6.43 µM 0.0540458381385449 0.482835761278176 no 1606 0.478449322015381 2244 5088750
SGTC_756 0508-1999 28.3 µM 0.0540000425750205 0.482852696042945 no 1607 0.478467565161381 2261 6753853
SGTC_1920 st075728 45.7 µM 0.05391278217975 0.482884964194582 no 1608 0.478502326385522 2311 3400306
SGTC_2540 epiandrosterone 100 µM 0.0534635850201963 0.483051075251143 no 1609 0.47868127203891 2329 441302 A steroid.
SGTC_772 k072-0172 35.3 µM 0.052999479625673 0.483222702394655 no 1610 0.47886616116549 2205 5861980
SGTC_2105 5350118 200 µM 0.0527394654987163 0.48331885752225 no 1611 0.478969746922255 2262 2133313
SGTC_1889 st059080 5.18 µM 0.0526644240059248 0.483346608596284 no 1612 0.478999642600117 2303 176925 Isolated from Daphnopsis sellowiana.
SGTC_123 0083-0120 66.675 µM 0.0525341289836397 0.483394793154599 no 1613 0.479051550936727 2271 16001701
SGTC_2360 9040895 200 µM 0.0522671562123631 0.483493523431819 no 1614 0.479157911538381 2254 4914414
SGTC_1070 indatraline 8.81 µM 0.0520457289480389 0.483575411109546 no 1615 0.479246128166731 2236 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_522 1273-0010 11.6 µM 0.0516810182976705 0.483710288999827 no 1616 0.479391431114377 2249 5705015
SGTC_2234 tolnaftate 200 µM 0.0516778571208604 0.483711458079585 no 1617 0.479392690558499 2320 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_675 1309-0189 238 µM 0.0514635104121338 0.483790729010777 no 1618 0.479478088887634 2261 4246530
SGTC_1612 st002233 45.4 µM 0.0497269557928164 0.484432974964809 no 1619 0.480169987705541 2313 1035021
SGTC_2986 9022445 71.43 µM 0.049133652023313 0.484652411290857 no 1620 0.480406392673742 2319 6459286
SGTC_1571 st070080 73.4 µM 0.0480654633888112 0.485047497799838 no 1621 0.480832035300066 2307 4315245
SGTC_622 1348-1566 26.3 µM 0.047336941448375 0.485316961637824 no 1622 0.481122343026156 2278 7340407
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.047249203285347 0.485349414460689 no 1623 0.481157306367 2339 6708630 An antioxidant.
SGTC_995 3931-2021 34.6 µM 0.0469195073221503 0.485471364137708 no 1624 0.481288690310126 2265 730143
SGTC_3107 9121808 49.47 µM 0.0462085356227543 0.485734346699009 no 1625 0.481572019650183 2322 662681
SGTC_2765 myclobutanil 7.74 µM 0.0453642948637903 0.486046632433806 no 1626 0.481908470122212 2269 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3082 9117008 49.47 µM 0.0439119591077057 0.486583873199377 no 1627 0.482487291253869 2256 41448529
SGTC_1320 1313-0481 95.3 µM 0.0408702103885485 0.487709139395077 no 1628 0.483699683131231 2312 6813365 YLR208W SEC13
SGTC_1421 4029-0249 71.4 µM 0.0408162588164884 0.487729099179033 no 1629 0.483721188749423 2337 2894095
SGTC_1120 ficusin 1.78878 µM 0.0402631660416115 0.487933721714214 no 1630 0.483941659596619 2271 6199 A DNA cross-linker.
SGTC_1489 4065-0444 182 µM 0.0391847265493766 0.488332710922217 no 1631 0.484371555366243 2349 2877968
SGTC_1934 st074720 32.6 µM 0.0388439848243025 0.488458777252692 no 1632 0.484507388230112 2336 17250992
SGTC_104 0074-0074 590.992 µM 0.0368438511302693 0.489198801965642 no 1633 0.485304754810708 2352 3943124
SGTC_2009 4012297 12.05 µM 0.0352946830531391 0.489772000667825 no 1634 0.485922381500002 2285 45595307
SGTC_3304 9125678 46.087 µM 0.0340825157377983 0.490220522462362 no 1635 0.486405675402435 2328 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3282 9108498 15.4605 µM 0.0340666318500127 0.490226399844771 no 1636 0.486412008479189 2306 16459645
SGTC_365 0121-0052 13.6 µM 0.0334964357083695 0.490437386159056 no 1637 0.486639354065632 2331 3101739
SGTC_380 3970-0968 6 µM 0.032467365550944 0.490818173650209 no 1638 0.487049670409887 2336 2891601
SGTC_1973 st070275 50.2 µM 0.0320997945916676 0.49095418821467 no 1639 0.487196233609614 2351 17118334
SGTC_402 epigallocatechin gallate 10 µM 0.0317868756529836 0.491069980382092 no 1640 0.487321006530155 2255 65064 An antioxidant.
SGTC_3228 9131799 49.47 µM 0.031523992484351 0.49116725795227 no 1641 0.48742582920782 2285 17015818
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0309040753557136 0.491396654822365 no 1642 0.48767301990657 2309 5282362
SGTC_432 NS 1619 61.3 µM 0.0304777564503171 0.49155441340744 no 1643 0.4878430164601 2245 4552 A K+/calcium channel activator.
SGTC_1923 st058458 19.1 µM 0.0295715461540047 0.491889759342589 no 1644 0.488204379132607 2361 3534982
SGTC_295 k015-0027 31 µM 0.0295566934199035 0.491895255691373 no 1645 0.488210301927282 2310 3887424
SGTC_1840 st055363 71 µM 0.0291766483538191 0.49203589430741 no 1646 0.488361852608841 2254 676033
SGTC_2962 9082311 13.18 µM 0.0284086795928675 0.492320090090436 no 1647 0.488668100841205 2333 16459453
SGTC_1068 loratadine 26.9 µM 0.0274406257115969 0.492678335238602 no 1648 0.489054147902645 2303 3957 A H1 histamine antagonist.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0274164334513662 0.492687288081415 no 1649 0.489063795588333 2368 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_109 0132-0036 33.701 µM 0.0271384666997118 0.49279015565055 no 1650 0.489174647030063 2339 67274 A color developer.
SGTC_2990 9074105 71.4286 µM 0.0265045830482685 0.493024739698536 no 1651 0.489427439070329 2369 6502001
SGTC_713 1488-1073 324 µM 0.0263783366707267 0.493071460528862 no 1652 0.489477786484751 2370 3312542
SGTC_335 4077-0256 27.6 µM 0.0262968195706713 0.493101628150736 no 1653 0.489510295825229 2352 3121989
SGTC_2624 nerol 100 µM 0.0259910578388147 0.493214783952961 no 1654 0.489632235427003 2349 637566 A natural product oil.
SGTC_520 3584-0023 682 µM 0.024496454059009 0.493767912165677 no 1655 0.490228306059317 2231 1340790
SGTC_2455 5377712 9.75 µM 0.0226905838320033 0.49443625084469 no 1656 0.490948543458485 2271 2243908
SGTC_2192 5915882 198.485 µM 0.0224443891014953 0.49452736687207 no 1657 0.49104673593797 2358 2876149
SGTC_3007 9078383 71.4286 µM 0.0223354952806392 0.49456766828239 no 1658 0.491090167399495 2349 6496995
SGTC_979 1426-2828 121 µM 0.0216548676367271 0.494819568608466 no 1659 0.491361632864812 2337 747872
SGTC_3022 9087993 49.47 µM 0.0205573194141518 0.495225775570146 no 1660 0.491799393718703 2364 17173644
SGTC_1614 st002383 48.6 µM 0.0198757390890249 0.495478033677183 no 1661 0.492071249362152 2372 1947235
SGTC_2003 4023581 200 µM 0.019838537887613 0.495491802180166 no 1662 0.492086087568591 2342 16641307
SGTC_3104 9120930 49.47 µM 0.0193769075016044 0.495662656226099 no 1663 0.492270216047177 2300 17014836
SGTC_2987 9018338 71.43 µM 0.0177463430496064 0.496266150675788 no 1664 0.492920605025773 2373 5055682
SGTC_2842 9000675 19.48 µM 0.0169075641959967 0.496576597742892 no 1665 0.493255179137333 2349 2989072
SGTC_2923 7992654 58.14 µM 0.015932985783741 0.496937309248426 no 1666 0.493643927244445 2372 2985126
SGTC_2768 sulfasalazine 50.2 µM 0.0157321919506649 0.497011627494707 no 1667 0.493724022354584 2380 5384001 An antioxidant and salicylic acid derivative.
SGTC_346 4513-0042 7.16 µM 0.0157130855169069 0.497018699214595 no 1668 0.493731643776766 2379 2827372
SGTC_289 k017-0060 526 µM 0.0148362747061192 0.497343227543738 no 1669 0.4940813998657 2387 5512909
SGTC_151 3013-0144 2.285 µM 0.0145087634760618 0.497464447625074 no 1670 0.49421204387863 2371 906558 YHR107C CDC12
SGTC_3277 9138724 49.47 µM 0.0130135291564973 0.498017873974861 no 1671 0.49480849953443 2324 15943418
SGTC_2237 6667747 47.222 µM 0.0119844490394164 0.498398766424346 no 1672 0.495219011017667 2300 729940 YDL015C TSC13
SGTC_3072 9116419 49.47 µM 0.011102330206247 0.498725265407956 no 1673 0.495570902059654 2387 17170162
SGTC_904 1141-0088 396 µM 0.00989706112300715 0.499171373455256 no 1674 0.496051708323479 2367 1378119
SGTC_2037 5169046 200 µM 0.00983312295164065 0.499195039020052 no 1675 0.496077214722192 2372 5718022
SGTC_1277 0873-0036 22 µM 0.00812178424987425 0.499828461064724 no 1676 0.496759912491653 2391 5965735
SGTC_2954 9074818 52.69 µM 0.0080927303920498 0.49983921484954 no 1677 0.496771502923035 2380 16648742
SGTC_1983 st071813 46.9 µM 0.00775374454319882 0.49996468462666 no 1678 0.496906734465124 2363 11838595
SGTC_1708 st033234 31.827 µM 0.00756291912390416 0.49996468462666 no 1679 0.496982860560508 2382 674664
SGTC_2821 7996764 71.43 µM 0.00741575101573033 0.49991021288341 no 1680 0.497041570494585 2387 2987135
SGTC_69 0096-0274 206.684 µM 0.00699222028551908 0.499753450283248 no 1681 0.497210530424304 2379 6741392
SGTC_454 lyso-paf C-16 6.67 µM 0.0057333903911309 0.499287516412657 no 1682 0.497712720694089 2390 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.00554819331349703 0.499218969019916 no 1683 0.497786602463044 2343 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3135 9127742 49.47 µM 0.00526529690087082 0.499114260007345 no 1684 0.497899460153048 2382 3643468
SGTC_91 0417-1751 58.384 µM 0.00515918760138996 0.499074985576367 no 1685 0.497941791063919 2391 6795624
SGTC_3036 9090181 49.47 µM 0.00422458976413966 0.498729061582887 no 1686 0.49831463753889 2393 25236586
SGTC_777 1315-0167 517 µM 0.00368344961768631 0.498528769050237 no 1687 0.498530519532714 2383 4221767
SGTC_2896 9052656 71.43 µM 0.0012690863364702 0.497635144523634 no 1688 0.499493707938806 2399 6469436
SGTC_1133 3473-0247 50 µM 0.000153258016798336 0.497222148460564 no 1689 0.499938858897528 2404 711311
SGTC_770 0389-1121 67.2 µM 8.74866470354607e-05 0.497197804914647 no 1690 0.499965097877572 2404 6753108
SGTC_424 splitomicin 100 mM 0 0.497165424045093 no 1691 0.5 2405 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3216 9129716 49.47 µM 0 0.497165424045093 no 1692 0.5 2405 8056934
SGTC_967 1306-0166 352 µM -0.000149936875442142 0.497109928918012 no 1693 0.499940183841219 2406 4437607
SGTC_1979 st071809 45.3 µM -0.00056249664449672 0.496957231237868 no 1694 0.49977559631776 2405 4976333
SGTC_1103 duloxetine 36.1 µM -0.000835744095226582 0.496856096434407 no 1695 0.499666586383631 2408 60835 A selective serotonin reuptake inhibitor.
SGTC_2516 gossypol 71.55 µM -0.00165872364181423 0.49655149511527 no 1696 0.499338265311224 2409 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3260 9137109 49.47 µM -0.00267952684006567 0.496173678088277 no 1697 0.49893102473121 2411 17478346
SGTC_1604 st002052 72.4 µM -0.00336237238355373 0.495920946965083 no 1698 0.498658610021272 2440 6254834 YHR062C RPP1
SGTC_88 0180-0332 8.668 µM -0.00408554344938148 0.495653292563441 no 1699 0.498370108513893 2410 3101745
SGTC_1416 3966-0321 25.3 µM -0.00441863887102059 0.495530010550004 no 1700 0.498237223868709 2415 582530 YLR208W SEC13
SGTC_1409 3909-8004 61.9 µM -0.00518593155027093 0.495246029346043 no 1701 0.497931121914695 2419 2119279
SGTC_897 1000-0139 31.4 µM -0.00527547221410081 0.49521288977899 no 1702 0.497895400846762 2403 6151020
SGTC_1410 3909-8106 77.9 µM -0.00630761535653794 0.494830889504999 no 1703 0.497483642231752 2420 1039210
SGTC_2933 9026794 32.47 µM -0.00686551408348519 0.494624410922731 no 1704 0.49726107767207 2425 17586027
SGTC_2495 cafestol 54.53 µM -0.00710419422765715 0.494536075725308 no 1705 0.497165860394061 2461 16667697 An anti-infammatory.
SGTC_3071 9117417 49.47 µM -0.00734389282346364 0.49444736386996 no 1706 0.497070236985042 2427 45595590 YGL055W OLE1
SGTC_2397 5161689 200 µM -0.00771864362645905 0.494308670079855 no 1707 0.49692073728586 2429 2259942
SGTC_1857 st056007 79.3 µM -0.0080701074963657 0.494178595316439 no 1708 0.496780527857918 2426 619834
SGTC_1272 0839-0021 27 µM -0.010242671042394 0.493374556270962 no 1709 0.495913836905206 2442 5027250
SGTC_49 0717-0965 32.132 µM -0.0105005613339407 0.49327911596961 no 1710 0.495810959097941 2516 5889349 YGL099W LSG1
SGTC_395 anisomycin 6.25 µM -0.0106302106530504 0.493231135362732 no 1711 0.495759239389707 2432 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_64 000l-0018 272.079 µM -0.0107058871617257 0.493203129053288 no 1712 0.495729050548674 2433 6811119
SGTC_1548 st061468 90.8 µM -0.0124278002340938 0.492565893991151 no 1713 0.495042152658 2433 390799
SGTC_2352 9027995 87.8 µM -0.0126471091858267 0.492484734803179 no 1714 0.494954667920894 2427 2997347
SGTC_2655 perillic acid 100 µM -0.0130418561053898 0.492338652453269 no 1715 0.494797199675794 2432 5702197 An apoptosis inducer.
SGTC_2272 7805186 180 µM -0.0144464788296907 0.491818858034943 no 1716 0.494236889253532 2425 2956062 YPR165W RHO1
SGTC_2649 anisomycin 9.56 µM -0.0146210852568598 0.491754244166485 no 1717 0.494167238723951 2429 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1516 st013856 110 µM -0.0188331190795966 0.490195632236113 no 1718 0.492487116649498 2525 5281404 A mutagen and neurotoxin.
SGTC_672 1441-0018 53.7 µM -0.0193911974033708 0.489989132849287 no 1719 0.492264516272101 2456 251141
SGTC_2436 5633522 8.09 µM -0.0210225547257346 0.489385515807906 no 1720 0.491613831790509 2454 5724242
SGTC_2165 5727197 32.143 µM -0.021048546542607 0.489375898792429 no 1721 0.491603464849725 2550 1361712
SGTC_856 0433-0016 11.3 µM -0.021619272231207 0.489164730905021 no 1722 0.491375830053375 2468 3911780
SGTC_1073 triclabendazole 3.09 µM -0.0227224101352233 0.488756579734884 no 1723 0.490935849873235 2459 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2240 6690706 185.951 µM -0.0230440642504186 0.488637572783727 no 1724 0.490807562040452 2443 805876
SGTC_862 0452-0056 10.2 µM -0.0230983596660493 0.488617484435517 no 1725 0.490785907067558 2454 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2723 salbutamol 83.58 µM -0.0231228674267325 0.488608417004844 no 1726 0.490776132496274 2440 9884233 β2-adrenoceptor agonist
SGTC_532 1548-0774 215 µM -0.0242105355742141 0.488206005349822 no 1727 0.490342337210725 2473 5932993
SGTC_1579 chlormadinone acetate 49.4 µM -0.0245253001366495 0.488089552080503 no 1728 0.490216801595686 2448 45114258 A steroidal progestin.
SGTC_359 0081-0058 15.9 µM -0.0263137764939457 0.487427890052559 no 1729 0.489503533331711 2472 3494159
SGTC_3242 9133940 49.47 µM -0.0271075981970291 0.48713421994715 no 1730 0.48918695725202 2536 17248444
SGTC_654 1124-0271 80.9 µM -0.0272296934239373 0.487089052084157 no 1731 0.489138266277382 2475 5403748
SGTC_1673 st016611 27.3 µM -0.0282852286583843 0.486698574737067 no 1732 0.488717330855136 2505 5226799
SGTC_2602 kawain 100 µM -0.0283045348801009 0.486691432845591 no 1733 0.488709631869541 2446 5369129
SGTC_1784 st039334 36.3 µM -0.0284446545715449 0.486639598925287 no 1734 0.488653754698728 2477 3496984
SGTC_1057 3448-5381 134 µM -0.0284599114201262 0.486633955033567 no 1735 0.488647670559916 2482 5497911
SGTC_933 2914-0560 114 µM -0.0292650648428053 0.486336112373869 no 1736 0.488326594589005 2460 463887
SGTC_1445 4239-0156 97.7 µM -0.0300250981893055 0.486054967540105 no 1737 0.488023518365495 2483 4008346
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0307535728322705 0.48578550312725 no 1738 0.487733033200835 2469 5106787 A p450 inhibitor.
SGTC_2497 7-hydroxyflavone 100 µM -0.0315913328367183 0.485475621844352 no 1739 0.487398977667955 2472 5281894
SGTC_1753 st043925 64 µM -0.0317701946074343 0.485409463316672 no 1740 0.487327657945108 2458 670181
SGTC_2094 5332512 191.667 µM -0.0334117485938856 0.484802293891712 no 1741 0.486673120435647 2489 755774
SGTC_534 k292-0788 63.4 µM -0.0341010079275873 0.484547364667211 no 1742 0.486398302371962 2459 4146317
SGTC_2212 7123476 200 µM -0.035340165683117 0.484089066152305 no 1743 0.485904247868634 2462 1085715
SGTC_3100 9120536 49.47 µM -0.0360642210770627 0.483821286281229 no 1744 0.485615575601141 2460 16421196
SGTC_2448 5185112 27.17 µM -0.0362010513746378 0.483770682682615 no 1745 0.485561023832372 2509 5718189
SGTC_1479 0549-0158 134 µM -0.0367727910934837 0.483559240483779 no 1746 0.485333084466069 2474 5440202
SGTC_1881 5652484 16 µM -0.0373949081562946 0.483329172865302 no 1747 0.485085066267786 2460 2255129
SGTC_3010 9080089 71.4286 µM -0.0384357739878163 0.482944258527547 no 1748 0.484670119263625 2472 17027233
SGTC_1214 0358-0031 63.7 µM -0.0393732577652079 0.482597588683346 no 1749 0.48429640029165 2552 4301366
SGTC_2822 7994718 71.43 µM -0.0396117805953283 0.48250938799579 no 1750 0.484201317627288 2469 1018011
SGTC_820 1582-0060 59.9 µM -0.0403977881364465 0.482218745146504 no 1751 0.483887996811436 2496 3848840
SGTC_2188 6126565 140.678 µM -0.040421866673265 0.482209841748577 no 1752 0.483878398704883 2483 874518
SGTC_1434 4073-0095 163 µM -0.0407911719883982 0.482073286717362 no 1753 0.483731188617756 2480 24133745
SGTC_1783 st039459 87.517 µM -0.0412599648965477 0.481899947997165 no 1754 0.483544324628975 2542 729761
SGTC_1773 st048542 73.5835 µM -0.0421664067110542 0.481564795953498 no 1755 0.483183021145776 2477 3237138
SGTC_2123 5259487 200 µM -0.0450053835526256 0.480515184748929 no 1756 0.482051508924833 2499 2173474
SGTC_3299 9121982 43.1275 µM -0.0450449465990434 0.480500558650222 no 1757 0.482035741543313 2522 17594604 YPL160W CDC60
SGTC_3218 9131285 49.47 µM -0.0466354449156709 0.479912587830896 no 1758 0.48140189089726 2509 17156417
SGTC_1734 st037168 69.4 µM -0.046750908838107 0.479869905148024 no 1759 0.481355877644376 2563 708907
SGTC_3248 9135562 49.47 µM -0.0472436629086136 0.479687755044032 no 1760 0.481159514191971 2503 17650701
SGTC_1389 3405-0187 19 µM -0.0483343510220749 0.479284589438733 no 1761 0.480724889189705 2525 799890
SGTC_1459 k035-0031 35.7 µM -0.0496730261746512 0.478789786085944 no 1762 0.48019147595505 2474 3877128 YMR208W ERG12
SGTC_784 4579-0127 173 µM -0.0514188282455544 0.478144549026176 no 1763 0.479495890923652 2640 1948547
SGTC_701 4424-0219 185 µM -0.0518609260831791 0.477981161571374 no 1764 0.479319754411804 2509 2911779
SGTC_2863 9028737 58.44 µM -0.0528647145710159 0.477610202162278 no 1765 0.478919849378962 2557 6460917
SGTC_1291 0993-0025 5.79 µM -0.0530814968587526 0.477530090779615 no 1766 0.478833487016826 2537 4353356
SGTC_2336 9001819 198.65 µM -0.0539423909343962 0.477211958400718 no 1767 0.478490531364949 2542 2989602
SGTC_3147 9097027 49.47 µM -0.0539863136738134 0.477195727702593 no 1768 0.478473034222846 2534 25236841
SGTC_624 k048-0052 28 µM -0.0540016001689809 0.477190078917885 no 1769 0.478466944676648 2542 6835531
SGTC_54 0159-0055 9 µM -0.0548848084543545 0.476863716734448 no 1770 0.478115117366268 2495 3319099
SGTC_169 k015-0017 16.025 µM -0.0551475718670997 0.476766623663696 no 1771 0.478010448456351 2522 1840002
SGTC_1167 k781-0610 148 µM -0.0587630236598571 0.475430829380977 no 1772 0.476570430193567 2545 4525169
SGTC_2992 9074591 71.4286 µM -0.0591199702759128 0.475298963706186 no 1773 0.476428276240446 2501 17741321
SGTC_2453 5731132 22.18 µM -0.0593125194784144 0.475227831977479 no 1774 0.47635159478476 2544 1362040
SGTC_125 0133-0007 11.75 µM -0.0593292677972739 0.475221644833221 no 1775 0.476344924918096 2580 26541
SGTC_631 k072-0230 41.5 µM -0.060451559347356 0.474807062898299 no 1776 0.475897997643569 2571 5773147
SGTC_776 4476-4378 112 µM -0.0612113577646879 0.474526403785895 no 1777 0.475595442253795 2608 2892008
SGTC_2383 9036125 200 µM -0.0617571499647896 0.474324803428203 no 1778 0.475378113844778 2521 79580
SGTC_1177 0983-0204 23.6 µM -0.0633367872951011 0.473741366857542 no 1779 0.474749161265322 2536 766818
SGTC_2394 5221648 200 µM -0.063362931879589 0.473731710866603 no 1780 0.474738751993407 2575 788586
SGTC_2181 6316240 54.2555 µM -0.0643894470545861 0.473352599819467 no 1781 0.474330066310612 2565 12779990
SGTC_620 0109-0052 432 µM -0.065875847119045 0.472803687638911 no 1782 0.473738335005296 2535 493037
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0658786792198248 0.472802641822327 no 1783 0.473737207609553 2528 5024745
SGTC_1488 4013-0813 75.9 µM -0.0664994345735832 0.472573418554645 no 1784 0.47349010392991 2516 2910057
SGTC_2032 5185112 25.99 µM -0.0665267056715789 0.472563348498526 no 1785 0.473479248374889 2559 5718189
SGTC_2130 NSC 7 2.4545 µM -0.0687355883912934 0.471747760900086 no 1786 0.472600044871008 2560 21448
SGTC_2334 9017922 200 µM -0.0689990595777591 0.471650487056027 no 1787 0.472495184032613 2621 3163164
SGTC_2917 7979103 53.79 µM -0.0690741241591454 0.47162277344152 no 1788 0.472465308875501 2589 2980565
SGTC_497 capsazepine 133 µM -0.0695647035015972 0.471441656433989 no 1789 0.472270065689263 2535 2733484 A calcium channel blocker.
SGTC_1126 isoteolin 1.0172 µM -0.0721963285592986 0.470470188416475 no 1790 0.471222833468173 2542 133323
SGTC_2300 7976697 71.57 µM -0.0723393805127627 0.470417385574078 no 1791 0.471165912828016 2563 2236109
SGTC_2900 5328528 85.29 µM -0.0725260156337955 0.470348496245705 no 1792 0.4710916512496 2514 795359
SGTC_1657 st012939 43.4 µM -0.0728811226755972 0.470217424302765 no 1793 0.470950357955875 2600 24207257
SGTC_1169 aniline yellow 25.8 µM -0.0731704162726852 0.470110646845163 no 1794 0.470835253829995 2577 6051 A DNA damaging agent.
SGTC_848 0368-0089 85.6 µM -0.0737980130833447 0.469879010016488 no 1795 0.470585554022932 2528 762535
SGTC_2789 5281112 71.43 µM -0.0744726277776887 0.469630030941889 no 1796 0.470317160269958 2575 765948
SGTC_2070 5230947 200 µM -0.0763965093053902 0.468920052301509 no 1797 0.469551823331203 2532 2835538
SGTC_1755 st041960 45.185 µM -0.0772602270343349 0.468601342676239 no 1798 0.469208265261753 2629 2257073
SGTC_3343 9148379 18.9835 µM -0.0781313209145675 0.468279931650209 no 1799 0.4688617964261 2593 1955036
SGTC_326 k292-0812 17.5 µM -0.0785596098953761 0.468121911704294 no 1800 0.468691457419169 2520 3579357
SGTC_405 ebelactone b 50 µM -0.0787905209706695 0.468036717675503 no 1801 0.468599621888911 2570 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_487 nimodipine 119 µM -0.0792717233542102 0.467859184040826 no 1802 0.468408248499992 2528 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1573 oleylamine 1.06 µM -0.0805995866431572 0.467369318659944 no 1803 0.467880197474095 2542 5356789 An amine of the fatty acid oleic acid.
SGTC_2409 alverine citrate 63.97 µM -0.0807686234416796 0.467306962400284 no 1804 0.467812980692856 2851 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_847 0342-0274 5.54 µM -0.0823670817465951 0.466717344392272 no 1805 0.46717740601887 2613 18097
SGTC_1328 1441-0025 69.2 µM -0.0824083776471637 0.466702112672731 no 1806 0.467160987156262 2547 4562601
SGTC_2431 5490079 200 µM -0.0836361467940161 0.466249280525772 no 1807 0.466672863310342 2590 5722345
SGTC_1974 st069448 26.9 µM -0.0839108566747991 0.466147966571757 no 1808 0.466563653813637 2589 6323587 YNR016C ACC1
SGTC_3284 9108171 64.8615 µM -0.0846855467675315 0.465862270024016 no 1809 0.466255693347636 2621 8687505
SGTC_2813 7971799 71.43 µM -0.0847253691901245 0.4658475844595 no 1810 0.466239863391629 2630 2234054
SGTC_182 3448-4371 550.524 µM -0.0852704818615166 0.465646564524965 no 1811 0.46602317905152 2524 3491403
SGTC_1351 1496-0003 46.5 µM -0.0872410647118844 0.464919950748155 no 1812 0.465239949424952 2619 3891978
SGTC_1266 0828-0227 32.9 µM -0.0893802341194478 0.464131306455093 no 1813 0.46438986573995 2643 3913820
SGTC_2993 9054257 71.4286 µM -0.0920812074544785 0.463135744430692 no 1814 0.463316759644688 2573 6470217 YGL055W OLE1
SGTC_160 3453-0671 289.699 µM -0.0926314214156933 0.462932967075519 no 1815 0.46309819019035 2585 5322268
SGTC_884 0851-0618 334 µM -0.0930025009654847 0.462796213840413 no 1816 0.462950787176468 2608 9642473
SGTC_2827 7993847 71.43 µM -0.0932075596029316 0.462720645859062 no 1817 0.462869334420867 2636 2985692
SGTC_3173 9105693 49.47 µM -0.0936744910708464 0.462548577817087 no 1818 0.462683867166074 2665 17096658
SGTC_2628 lathosterol 100 µM -0.0937520109105893 0.462520011803366 no 1819 0.462653076725214 2670 6710616
SGTC_92 0063-0024 660.874 µM -0.0940864871745529 0.462396759722078 no 1820 0.462520227217476 2534 3594437
SGTC_2294 7971431 200 µM -0.0954665080273153 0.461888270339133 no 1821 0.461972145725081 2660 5741572
SGTC_2437 5741531 144.16 µM -0.0955792770712045 0.461846721635125 no 1822 0.461927362168898 2661 2262990
SGTC_3058 9093861 49.47 µM -0.0956487557145366 0.461821123083304 no 1823 0.461899770610751 2658 17217477
SGTC_2521 angolensin 13.4 µM -0.0957988544007719 0.461765821608034 no 1824 0.46184016361602 2688 821428 A flavenoid.
SGTC_1140 3229-1848 2.98 µM -0.0965516847304733 0.461488464411525 no 1825 0.461541213573126 2601 2849525
SGTC_886 0866-0150 153 µM -0.0971859840285987 0.461254790863345 no 1826 0.461289349238785 2683 271463
SGTC_1249 0481-0015 10.2 µM -0.0977414037478909 0.461050187246064 no 1827 0.461068818752051 2591 4227577
SGTC_170 4197-0004 226 µM -0.0983613782160729 0.460821815350628 no 1828 0.460822670818734 2690 218692
SGTC_1234 0326-0494 15.5 µM -0.0990006936499435 0.460586332608746 no 1829 0.460568859679072 2685 1547813
SGTC_705 1124-0212 310 µM -0.0996200550287194 0.46035821283939 no 1830 0.460322985708797 2570 9554485
SGTC_3253 9135987 49.47 µM -0.100197300081756 0.46014561686762 no 1831 0.460093844726019 2670 4182430
SGTC_3115 9123671 49.47 µM -0.101069885061856 0.459824270578208 no 1832 0.459747491921031 2573 3286988
SGTC_1829 berberine 14.4 µM -0.101362412415944 0.459716547587423 no 1833 0.459631386649887 2750 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1776 st049249 45.9 µM -0.101684428728358 0.459597968728271 no 1834 0.459503581074868 2616 1822314
SGTC_3075 9116269 49.47 µM -0.102719252421348 0.459216931010158 no 1835 0.459092896623748 2704 17015205 YNL244C SUI1
SGTC_950 1165-0508 94.1 µM -0.104181748644783 0.45867848177103 no 1836 0.45851255880945 2656 6148369
SGTC_3123 9126162 49.47 µM -0.104517276988873 0.458554960495893 no 1837 0.458379429156483 2606 25239884
SGTC_2102 5377816 72.7585 µM -0.104628939949992 0.458513853823392 no 1838 0.458335124988529 2703 1379702
SGTC_1145 3546-0597 10.2 µM -0.105484467361511 0.45819892184085 no 1839 0.457995697237141 2640 875334
SGTC_824 1304-0008 100 µM -0.107031423227085 0.45762953182211 no 1840 0.457382025402581 2609 768245
SGTC_2949 9072542 2.23 µM -0.108040689880084 0.457258096555089 no 1841 0.456981707622027 2676 16457352
SGTC_1633 st005664 67.9 µM -0.109645879590358 0.456667423795871 no 1842 0.456345111668454 2598 2063822
SGTC_939 1165-0479 45.3 µM -0.109661403408807 0.456661711854326 no 1843 0.456338955681943 2607 1377347
SGTC_2324 6149169 200 µM -0.11015376233693 0.456480554543834 no 1844 0.456143715676743 2670 2888231
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.110564842909323 0.456329309514924 no 1845 0.455980713898996 2696 7104
SGTC_730 1436-0052 41.2 µM -0.111726321675719 0.455902011763238 no 1846 0.45552020415646 2601 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_29 0299-0004 12.984 µM -0.112239943602893 0.455713071038647 no 1847 0.455316579416575 2597 16871 A napthoquinone isolated from Swertia calycina.
SGTC_270 tamoxifen 5.46 µM -0.113143816098284 0.455380597267324 no 1848 0.454958268887951 2632 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_606 k015-0008 38.6 µM -0.113484621232487 0.455255246127875 no 1849 0.454823177396151 2677 1970475
SGTC_1345 1488-0192 31.4 µM -0.113528980668773 0.45523893066267 no 1850 0.454805594176391 2635 658348
SGTC_204 PMA1.184 62.41 µM -0.115556022484049 0.454493462716738 no 1851 0.454002209152462 2581 2252213 YGL008C PMA1
SGTC_3200 9114385 49.47 µM -0.115885890929735 0.454372164893511 no 1852 0.453871488879669 2724 17018030 YLR208W SEC13
SGTC_2977 9011197 71.43 µM -0.116363952455928 0.454196381695161 no 1853 0.453682051522892 2833 2704722
SGTC_1977 st070720 65.3 µM -0.120879302211313 0.452536535084236 no 1854 0.451893318191855 2727 682188
SGTC_547 1120-0019 610 nM -0.121824235883506 0.452189280564222 no 1855 0.451519109724643 2612 3676939
SGTC_2939 9044578 71.43 µM -0.122151578122243 0.452068993787594 no 1856 0.451389487123156 2632 2653634
SGTC_2276 7947513 42.08 µM -0.124755322189215 0.451112366865512 no 1857 0.45035862934871 2715 2105100
SGTC_3241 9133421 49.47 µM -0.125133698809171 0.450973373137909 no 1858 0.450208852584907 2610 17018221
SGTC_1109 tnp00067 928.257 nM -0.126207493255736 0.450578955838403 no 1859 0.449783840018555 2644 676295
SGTC_2760 etidronate 98.04 µM -0.127219040117497 0.45020744743847 no 1860 0.449383517994492 2674 3305 A chelator and antioxidant.
SGTC_1245 0418-0076 17.2 µM -0.127805716290156 0.449992000250375 no 1861 0.449151363110572 2794 6790114
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.127895758194109 0.449958935143116 no 1862 0.449115733974846 2602 6708784 An antioxidant flavonoid
SGTC_1462 k081-0014 26.5 µM -0.12884690362583 0.449609677631105 no 1863 0.448739395549371 2652 3270634
SGTC_2259 7964009 200 µM -0.128974057580066 0.449562990064137 no 1864 0.448689088203858 2812 313134
SGTC_3288 9119690 36.221 µM -0.130395085911519 0.449041273716688 no 1865 0.448126927136485 2673 17595618 YKL019W RAM2
SGTC_577 r071-0003 38.6 µM -0.131148364386817 0.448764750723449 no 1866 0.447828971143202 2643 4568517 YMR134W ERG29
SGTC_1523 st012844 44.7 µM -0.133190122053264 0.448015362015333 no 1867 0.447021511352729 2771 4274103
SGTC_1195 1502-0147 41.1 µM -0.133433188692455 0.447926161285363 no 1868 0.446925399647924 2644 817940
SGTC_858 0438-0351 2.77 µM -0.133747692631435 0.447810748363937 no 1869 0.44680104533412 2654 2799119
SGTC_450 aminopyrene 156 nM -0.133896098646497 0.447756289620229 no 1870 0.446742367668046 2657 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1659 st012954 42.1 µM -0.134028385775977 0.447707746657301 no 1871 0.446690064167103 2753 24207262
SGTC_614 0462-0418 107 µM -0.135144784691368 0.447298113646033 no 1872 0.446248700944053 2662 5188303
SGTC_1700 st030840 7.9285 µM -0.137180947742049 0.446551142604935 no 1873 0.445443885014383 2766 5499307
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.137440453849438 0.446455955767282 no 1874 0.445341328440431 2665 688662
SGTC_993 3909-8757 62.7 µM -0.138307416057996 0.446137976438525 no 1875 0.444998732337039 2701 4288324 YLR208W SEC13
SGTC_1468 k284-1086 134 µM -0.138309236670076 0.446137308721447 no 1876 0.444998012931737 2670 15996457
SGTC_2152 5568786 200 µM -0.13898653754447 0.445888916413098 no 1877 0.444730393637425 2629 5399883
SGTC_3181 9108277 49.47 µM -0.139360765408499 0.445751681748615 no 1878 0.444582537215252 2671 17097298
SGTC_2062 5245942 200 µM -0.142643079145697 0.444548291045948 no 1879 0.443286036552511 2628 1376160
SGTC_1156 4092-0367 4.88 µM -0.144006377197932 0.444048616283052 no 1880 0.442747716926811 2677 1357585
SGTC_1813 st051246 8.6015 µM -0.14531907536059 0.443567571371069 no 1881 0.44222947731392 2688 5291959
SGTC_2740 felodipine 17.08 µM -0.146535672617606 0.443121817346299 no 1882 0.441749265582172 2754 3333 L-type calcium channel blocker
SGTC_2970 9090938 41.86 µM -0.146979183704093 0.442959335384778 no 1883 0.441574225430353 2824 17217104
SGTC_2815 7968870 71.43 µM -0.147223399183615 0.442869870214842 no 1884 0.441477845979086 2693 2977326 YHR190W ERG9
SGTC_385 1494-0393 12.4 µM -0.147634465658587 0.442719287929271 no 1885 0.441315626738725 2704 3090647
SGTC_1175 0741-0056 27.6 µM -0.14908456900801 0.442188150829659 no 1886 0.4407434509791 2841 765927
SGTC_503 tyrphostin 8 294 µM -0.149418750645185 0.442065763034244 no 1887 0.440611608469351 2719 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_315 k915-0449 187 µM -0.149503455536615 0.442034742324688 no 1888 0.440578191444177 2701 20970215 YNL149C PGA2
SGTC_550 4123-0385 25.7 µM -0.149601995605859 0.44199865532987 no 1889 0.440539316819441 2679 5731123
SGTC_348 k064-0012 10.7 µM -0.150669229514232 0.441607847611916 no 1890 0.440118323688625 2632 5066323
SGTC_711 k292-0785 179 µM -0.152599319610232 0.440901217345337 no 1891 0.439357130793795 2657 4146315
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.153035852328971 0.440741423230488 no 1892 0.439185001107767 2803 521171
SGTC_2278 7948257 134.34 µM -0.154870725945612 0.440069868033557 no 1893 0.438461616236034 2720 1247028
SGTC_1852 st056254 31.4 µM -0.155087923007346 0.439990386293044 no 1894 0.438376001516168 2716 442583
SGTC_479 n-linoleoylglycine 10 µM -0.155904659143961 0.439691529106424 no 1895 0.438054086376986 2689 6433346 An anti-infammatory.
SGTC_3042 9091578 49.47 µM -0.156147323852578 0.439602740712225 no 1896 0.437958448389478 2656 25236497
SGTC_2666 tannic acid 100 µM -0.157369176478199 0.43915572429021 no 1897 0.437476952177964 2747 16134267 A thiamine antagonist.
SGTC_703 3875-0075 71.8 µM -0.157429168745556 0.439133778032256 no 1898 0.437453313367006 2707 2850814
SGTC_2163 5671233 125 µM -0.157979714532593 0.438932387157279 no 1899 0.437236391715522 2770 701023
SGTC_433 pimozide 108 µM -0.159468302966405 0.438387937493302 no 1900 0.436649964646207 2667 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1269 0831-0796 3.05 µM -0.159538039375122 0.438362434325474 no 1901 0.436622495501051 2783 927758
SGTC_541 4513-1321 94 µM -0.159921548312806 0.438222186587094 no 1902 0.436471436939964 2712 747515
SGTC_3220 9131269 49.47 µM -0.16212217861652 0.437417575095727 no 1903 0.435604820612474 2651 17722206
SGTC_3163 9099914 49.47 µM -0.163642798696518 0.436861745169151 no 1904 0.435006175175183 2743 16268368
SGTC_2378 9074213 121.43 µM -0.164388270503973 0.436589299455773 no 1905 0.434712748372665 2705 657714
SGTC_2583 asiatic acid 100 µM -0.167849719030519 0.435324648612919 no 1906 0.433350753597082 2843 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1004 4084-0029 199 µM -0.168653622710573 0.435031034077557 no 1907 0.433034549908729 2839 716894 YLR208W SEC13
SGTC_1440 4100-1550 40 µM -0.169990202333672 0.434542946495184 no 1908 0.432508920956869 2715 742806
SGTC_2047 4141938 200 µM -0.170111992020554 0.434498476700889 no 1909 0.432461031352288 2716 3807862
SGTC_905 2-aminofluorene 215 µM -0.170304217948656 0.434428289788533 no 1910 0.432385447138058 2710 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3097 9117246 49.47 µM -0.170817725174798 0.434240804480465 no 1911 0.432183545621803 2688 16423892
SGTC_2524 avocatin b 10.57 µM -0.171604066844082 0.433953733966937 no 1912 0.43187440500373 2822 6710748
SGTC_2919 7978188 46.38 µM -0.171800812688754 0.433881913212951 no 1913 0.43179706329586 2810 2980291
SGTC_428 3448-4153 16.5 µM -0.174235718213387 0.432993248642486 no 1914 0.430840107880053 2666 3834874
SGTC_3342 9147791 14.508 µM -0.174315126911902 0.432964272623942 no 1915 0.430808905841828 2704 1838168
SGTC_1748 st037455 53.6035 µM -0.174874969995169 0.432759997638953 no 1916 0.43058893911908 2887 580690
SGTC_2044 5102272 200 µM -0.175498775649508 0.432532405221876 no 1917 0.430343866370523 2819 592666
SGTC_2281 7943571 200 µM -0.177099657377831 0.431948434018453 no 1918 0.429715055522382 2843 1244024
SGTC_448 monastrol 171 µM -0.178391144829935 0.43147743224322 no 1919 0.42920790158455 2755 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_935 2996-0153 430 µM -0.181840216047957 0.430220045070371 no 1920 0.427854061392915 2793 23738523
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.183617339963327 0.429572455268913 no 1921 0.427156829543099 2706 2333 A French combination drug.
SGTC_1671 st016596 74.5 µM -0.184187719135499 0.429364647302052 no 1922 0.426933096686085 2762 2829167
SGTC_917 harmaline 728.087 nM -0.184189991587336 0.429363819411918 no 1923 0.426932205357331 2841 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.184443147393321 0.429271592695069 no 1924 0.42683291183869 2734 16623 A steroid.
SGTC_2685 mycophenolic acid 18.85 µM -0.184551870073965 0.429231985323975 no 1925 0.426790269730217 2797 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_619 1652-1634 108 µM -0.18494529674396 0.429088667035574 no 1926 0.426635971060447 2783 5400454
SGTC_114 0364-0001 490.298 µM -0.185940790631813 0.428726068237905 no 1927 0.426245596828 2789 4003655
SGTC_2180 6301957 200 µM -0.188164865192962 0.427916188835904 no 1928 0.425373707003224 2786 845462
SGTC_2082 5219693 150 µM -0.188904019954743 0.427647098438839 no 1929 0.425084021417871 2733 2834649
SGTC_751 0833-0568 350 µM -0.189239948142021 0.427524814394408 no 1930 0.424952379596041 2816 6954252
SGTC_1926 methyl fluorone black 53.6 µM -0.18929374758828 0.427505231052032 no 1931 0.42493129772094 2736 72721 Reacts with homocysteine.
SGTC_2007 4011539 71.82 µM -0.189331747259193 0.427491399036521 no 1932 0.424916407282253 2729 45595301
SGTC_2851 9015922 71.43 µM -0.189460552409027 0.427444514166529 no 1933 0.42486593487422 2917 2996893
SGTC_837 0091-0265 12.5 µM -0.19072789373775 0.426983258677369 no 1934 0.424369391897717 2746 759367
SGTC_2941 9056145 11.23 µM -0.191193135084931 0.42681395667563 no 1935 0.42418714090895 2706 2119517
SGTC_2416 tofa 880 nM -0.192376149625807 0.42638351676316 no 1936 0.423723786653755 2778 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2221 6807166 181.081 µM -0.193061885116337 0.426134051969232 no 1937 0.423455251156996 2794 674925
SGTC_2951 9072950 58.06 µM -0.193440804907857 0.425996216813022 no 1938 0.42330688059071 2751 16488155
SGTC_733 4069-0007 56.1 µM -0.195911279054288 0.425097784108078 no 1939 0.422339804466117 2763 5717425 YNL287W SEC21
SGTC_1906 st060206 94.7 µM -0.197079732205297 0.424672990109405 no 1940 0.421882571867409 2889 5133468
SGTC_2638 epoxomicin 18 µM -0.199772470957121 0.42369437219563 no 1941 0.420829266154452 2864 9915668 A protesome inhibitor.
SGTC_2607 solasodine 47.35 µM -0.199939958746938 0.423633517843859 no 1942 0.420763769395199 2792 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2539 epi(13)torulosol 80 µM -0.2005225622939 0.423421851168794 no 1943 0.420535957080903 2859 6708597
SGTC_226 1,3-diallylurea 8.28947 mM -0.200873227356895 0.423294461103592 no 1944 0.420398851242481 2850 74537 YKL182W FAS1
SGTC_1962 st076595 64.5 µM -0.202577923257552 0.422675291408636 no 1945 0.419732473451661 2758 279619
SGTC_189 3970-0742 2.116 µM -0.202596485421126 0.422668550416332 no 1946 0.419725218632416 2778 2891807
SGTC_17 0960-0276 49.807 µM -0.20284412773875 0.422578619373392 no 1947 0.419628432943609 2756 6821114
SGTC_1374 2889-5571 141 µM -0.205302339034449 0.421686142142486 no 1948 0.418667958348616 2835 2853281
SGTC_2652 actinonin 100 µM -0.206858386712728 0.421121411612443 no 1949 0.418060228072912 2747 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2011 4012611 177 µM -0.207299809085653 0.420961237342551 no 1950 0.417887861618133 2771 2049887
SGTC_1218 1348-1416 30.7 µM -0.208469861490919 0.420536736159173 no 1951 0.417431056356169 2753 6787668
SGTC_1698 5-fluorocytosine 1.055 µM -0.208484602618535 0.420531388588676 no 1952 0.417425301917653 2880 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2979 9012552 45.46 µM -0.208583638252564 0.420495462271346 no 1953 0.417386642208453 2869 17100905
SGTC_551 k048-0028 34.9 µM -0.208651332329337 0.420470905846063 no 1954 0.417360217499361 2935 6836383
SGTC_1940 st075990 51.1 µM -0.211388017594776 0.419478417348567 no 1955 0.416292253034399 3036 1084979
SGTC_3143 9086658 49.47 µM -0.211558683670113 0.419416540348127 no 1956 0.416225672660483 2856 25236626
SGTC_941 3237-0776 460 µM -0.211593238784994 0.41940401222581 no 1957 0.416212192286412 2954 760008
SGTC_2825 7998094 58.44 µM -0.213356577108825 0.418764814210979 no 1958 0.415524423568106 2857 2987815
SGTC_3305 9127027 53.8275 µM -0.213618226054764 0.41866998649444 no 1959 0.415422392563579 2828 41905295
SGTC_1239 0337-0584 35.4 µM -0.214243434949911 0.418443415270381 no 1960 0.415178613075995 2948 914301 YML130C ERO1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.214530776344129 0.418339293878216 no 1961 0.415066584768629 2897 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2492 derrusnin 100 µM -0.214694805763339 0.418279858534814 no 1962 0.415002636277203 2734 1715307 Part of coumarin class of compounds.
SGTC_1042 0350-0096 82 µM -0.215659118047984 0.417930481964564 no 1963 0.414626735184954 2753 3122515
SGTC_643 k048-0106 28.4 µM -0.217046917229407 0.417427787084697 no 1964 0.414085890837493 2904 6763920
SGTC_2463 5473429 200 µM -0.217085151017584 0.417413939775555 no 1965 0.414070992907642 2846 5399405
SGTC_1072 oxiconazole 14.9 nM -0.218058918219831 0.417061300541003 no 1966 0.413691602832791 2798 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2057 5236571 38.335 µM -0.218822596765419 0.416784789296978 no 1967 0.413394121876591 2935 54684039 YBR257W POP4
SGTC_1765 st044815 90.4 µM -0.22058781829379 0.416145799079954 no 1968 0.412706693511805 2875 645695
SGTC_1608 st001473 40.5 µM -0.22137578228013 0.41586063646457 no 1969 0.41239992379734 2783 7292267
SGTC_3223 9129970 49.47 µM -0.222469512541107 0.415464891081221 no 1970 0.41197420204085 2787 17248386
SGTC_1909 st060837 51.5 µM -0.222548840174703 0.41543619122358 no 1971 0.411943328706765 2860 678937
SGTC_1624 st003710 6.25 µM -0.223059235151792 0.415251546779686 no 1972 0.411744702335675 2986 24207033
SGTC_3061 glucosamine 200 µM -0.223536863402239 0.415078773231689 no 1973 0.411558848012234 2829 91431 and experimental redox chemotherapeutic
SGTC_3134 9127454 49.47 µM -0.226768200279327 0.41391032742853 no 1974 0.41030199602995 2836 24262820
SGTC_1089 terbinafine 2.25 µM -0.227020880645398 0.41381899062503 no 1975 0.410203752812693 2925 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_572 0960-0087 17.7 µM -0.228258650047336 0.413371639448429 no 1976 0.409722584253241 2828 6796365
SGTC_2213 7173844 200 µM -0.22830146815675 0.413356166255054 no 1977 0.409705941636081 2828 892728
SGTC_426 0988-0037 14.6 µM -0.22837303443133 0.413330304628817 no 1978 0.409678125495351 2921 5383008
SGTC_1899 st063254 59.6 µM -0.228718062843223 0.413205628332305 no 1979 0.409544027385497 2776 3093813
SGTC_1780 st038448 24.544 µM -0.229929403580229 0.412767978759537 no 1980 0.409073313807757 3002 728868 YDL195W SEC31
SGTC_3068 9116768 49.47 µM -0.231618516924648 0.41215789412521 no 1981 0.408417162072561 2915 41904888
SGTC_2148 5546263 113.568 µM -0.232436835699424 0.411862404798217 no 1982 0.408099370740149 2802 792097
SGTC_2738 aclarubicin 5.55 µM -0.23314463078674 0.411606865116789 no 1983 0.407824549648145 2896 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_742 0kpi-0133 140 µM -0.233211735566489 0.411582639802925 no 1984 0.407798496705878 2982 2728852
SGTC_2369 9071472 200 µM -0.234710182420773 0.411041777543283 no 1985 0.407216842028745 2964 17296037
SGTC_2222 6885208 172.143 µM -0.235062691474033 0.410914564428606 no 1986 0.407080037658939 2855 609514
SGTC_2720 fluspirilene 36.88 µM -0.236617762816424 0.41035348384087 no 1987 0.406476669371931 2916 3396 An atypical antipsychotic.
SGTC_1919 st067113 52.3 µM -0.237356235139403 0.41008710204549 no 1988 0.40619021947231 2960 1268243
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.237432344437046 0.410059650249664 no 1989 0.406160699889234 2855 689007
SGTC_27 0485-0001 32.618 µM -0.238048819718624 0.409837310576893 no 1990 0.405921614829589 2791 2054479
SGTC_656 4090-1979 187 µM -0.238700636497256 0.409602256072203 no 1991 0.405668861583054 2949 22330961
SGTC_113 0099-0221 2.5 µM -0.239039095595293 0.409480215663353 no 1992 0.405537633709093 2999 89219
SGTC_199 4063-0024 41.6 µM -0.239797474733213 0.409206793803555 no 1993 0.405243632367928 2955 306215
SGTC_2784 7567673 72.73 µM -0.240394656609248 0.408991520196453 no 1994 0.405012160091666 2779 3471247
SGTC_1146 3579-1023 7 µM -0.240521947919967 0.408945637455077 no 1995 0.404962825296641 2932 X1146
SGTC_1998 st075797 76.8 µM -0.240658614948784 0.408896376581704 no 1996 0.404909858399022 2826 24208315
SGTC_2373 9071805 200 µM -0.241319203031683 0.408658291568168 no 1997 0.404653864376285 2965 10149009
SGTC_458 nppb 133 µM -0.242835456852765 0.408111940480382 no 1998 0.404066433465686 3022 4549 A chloride channel blocker.
SGTC_2717 st081029 62.2815 µM -0.244080569348092 0.407663423128129 no 1999 0.403584210463851 2938 5292846
SGTC_459 nigericin 15.3 µM -0.245121505055202 0.407288547656838 no 2000 0.403181176072496 2950 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1315 1237-0019 3.69 µM -0.245745670457496 0.407063805689242 no 2001 0.402939558057282 2942 825140
SGTC_2687 chenodiol 100 µM -0.246444533945729 0.406812203644453 no 2002 0.4026690679636 2932 5702181 A cholesterol synthesis inhibitor.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.247996525496841 0.406253599514332 no 2003 0.402068547550608 2884 2374 Ca(2+)-ATPase inhibitor.
SGTC_3085 9117376 49.47 µM -0.249243511023489 0.405804913531442 no 2004 0.401586212118936 2924 16480349
SGTC_896 0964-0007 44.5 µM -0.249879520355766 0.405576114475568 no 2005 0.401340260655697 2816 6756758
SGTC_3209 9113616 49.47 µM -0.250851069335928 0.405226670126421 no 2006 0.400964627985806 3050 16649353
SGTC_2942 9052777 62.25 µM -0.250864073301319 0.405221993403814 no 2007 0.400959600846744 2885 6469503
SGTC_2597 laccaic acid a 100 µM -0.250956064975085 0.40518891007108 no 2008 0.400924038706151 2990 5491415 A textile dye.
SGTC_1996 st072960 66.8 µM -0.251210605629273 0.405097372131369 no 2009 0.400825642661337 2953 1719405
SGTC_2522 biochanin a 4.94 µM -0.251591629038821 0.404960358152519 no 2010 0.400678364799985 2969 5280373 A possible chelator.
SGTC_2483 5729050 27.16 µM -0.251601924866344 0.404956655989621 no 2011 0.400674385325721 3010 2865180
SGTC_2002 4023503 131 µM -0.252134146146274 0.404765292010541 no 2012 0.400468688771577 2932 4736863 YCR052W RSC6
SGTC_521 r062-0005 13.8 µM -0.252409965173886 0.404666128257452 no 2013 0.400362099184752 2822 2832033
SGTC_3105 9121040 49.47 µM -0.253868600540723 0.404141814767393 no 2014 0.399798536689447 2780 41448907
SGTC_286 k060-0067 22.9 µM -0.253927068901362 0.404120801616561 no 2015 0.399775951029809 2881 5985051
SGTC_1876 myriocin 605 nM -0.254684159080318 0.403848733304785 no 2016 0.399483526052803 3007 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2743 auranofin 4.32 µM -0.256396574685138 0.403233530529812 no 2017 0.398822316244386 2889 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_369 0957-0393 4.5 µM -0.257899201277905 0.402693893755101 no 2018 0.398242350651944 2916 6997992
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.258114760024177 0.402616495536316 no 2019 0.398159170302043 2885 2724 A muscle relaxant with antifungal properties.
SGTC_2171 5739187 198.077 µM -0.258301117857241 0.402549585232251 no 2020 0.398087261803677 2802 2262761
SGTC_38 0929-0051 58.268 µM -0.258452083599066 0.402495384271029 no 2021 0.398029012323538 2995 1379719
SGTC_3327 9140648 26.9345 µM -0.258514453643458 0.402472992212223 no 2022 0.398004947774365 3005 8029710
SGTC_139 0099-0334 718.624 µM -0.260770098137285 0.401663387574795 no 2023 0.397134902516307 2835 97690
SGTC_2999 9069765 71.4286 µM -0.262938735649248 0.40088540953113 no 2024 0.396298899859467 2957 2097066
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.263005635683662 0.400861416013019 no 2025 0.396273117674121 2991 16725076
SGTC_2693 st077581 40.7 µM -0.263351009672604 0.400737554507964 no 2026 0.396140023373631 2981 25238761
SGTC_1632 st005650 90 µM -0.263824035234921 0.400567929502968 no 2027 0.3959577565464 2995 2759605
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.264077285840094 0.400477122590442 no 2028 0.395860183038467 3049 1273210
SGTC_1270 0831-1170 17.3 µM -0.264703314887786 0.400252673307505 no 2029 0.395619011825566 2854 6764716
SGTC_190 3970-0790 3.722 µM -0.26519335209324 0.400077003961975 no 2030 0.395430257941547 2946 2832352
SGTC_1322 1348-1070 12 µM -0.265284279445706 0.400044410397408 no 2031 0.395395236989409 2894 6758089
SGTC_1347 1493-0251 600 nM -0.265966343805925 0.399799941729464 no 2032 0.395132564736363 3006 3986378
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.269885106717775 0.39839612434742 no 2033 0.39362432264307 2956 279621
SGTC_336 4111-0029 111 µM -0.270152935959946 0.398300227713084 no 2034 0.393521299263411 2921 3131175
SGTC_1046 2001-0062 216 µM -0.270693587082572 0.398106665541565 no 2035 0.393313354750108 2856 739778
SGTC_2766 oltipraz 83.91 µM -0.272566329861345 0.397436386338163 no 2036 0.392593298541735 3032 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_965 1291-5240 308 µM -0.272681145406497 0.39739530217796 no 2037 0.3925491647165 3010 2834598
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.272697613563392 0.397389409511777 no 2038 0.392542834652485 3049 5377381
SGTC_1209 2323-2347 50.3 µM -0.274736503523177 0.396660031497287 no 2039 0.391759342070567 2941 5412760
SGTC_552 k242-0005 476 µM -0.275970185611518 0.396218878168269 no 2040 0.391285482875697 3014 4088318
SGTC_220 paclitaxel 373.376 µM -0.276448071536141 0.396048026241414 no 2041 0.391101969461036 2998 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_327 1273-0057 3.96 µM -0.278013887444571 0.395488361848085 no 2042 0.39050084910215 2943 3108138
SGTC_2715 st079500 56.4 µM -0.27804665171842 0.395476653319678 no 2043 0.390488273611147 2862 28246688
SGTC_877 0771-0151 33.1 µM -0.279216699604149 0.395058590942969 no 2044 0.390039264327515 2993 6166523
SGTC_2830 7992007 71.43 µM -0.280479271399289 0.394607604925641 no 2045 0.389554913262341 2766 1952075
SGTC_3188 9110789 49.47 µM -0.280708250431506 0.394525829564324 no 2046 0.389467090082558 3065 849217
SGTC_2440 5628896 157.78 µM -0.280840625938835 0.394478556373333 no 2047 0.389416321030373 2902 5522048
SGTC_2865 9030313 51.95 µM -0.281299877261954 0.394314563195469 no 2048 0.389240202220979 2875 42562754
SGTC_1296 1068-0102 11.9 µM -0.282752483459849 0.393795978279495 no 2049 0.388683290574969 2993 767053
SGTC_1198 1612-1005 86.7 µM -0.282943850373222 0.393727673714954 no 2050 0.388609939840312 3103 6998509
SGTC_942 3253-1115 227 µM -0.284943345939729 0.393014189985701 no 2051 0.387843773315706 3107 46497897
SGTC_3347 9188721 44.724 µM -0.285430842574343 0.392840290034252 no 2052 0.387657040462047 2972 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1342 1486-1464 234 µM -0.28554572756828 0.392799311336057 no 2053 0.387613038190393 2906 3253938
SGTC_2523 spermine 47.74 µM -0.285654550628135 0.392760495984417 no 2054 0.387571359040309 3026 1103 A DNA binding polyamine.
SGTC_634 1611-4317 11.2 µM -0.2859171441931 0.392666837677103 no 2055 0.387470791238454 2924 2843522
SGTC_2505 galangin 7.89 µM -0.290086516317963 0.391180598776628 no 2056 0.385875025464096 2870 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1992 st073643 23.3 µM -0.290234561368982 0.391127854827832 no 2057 0.385818398712135 2883 3161292
SGTC_2415 st077333 57.7 µM -0.290675755974606 0.390970682487223 no 2058 0.38564965764034 3157 2766255
SGTC_2097 5376186 200 µM -0.291005439317532 0.390853246838738 no 2059 0.385523579741218 3051 742755
SGTC_331 k048-0133 24.5 µM -0.291148985812248 0.390802117623835 no 2060 0.385468688297629 2908 6813582
SGTC_2417 cerulenin 830 nM -0.291981168159648 0.39050574335629 no 2061 0.385150511267089 3015 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3002 9075603 71.4286 µM -0.293790483087677 0.389861591802242 no 2062 0.384459003869814 2922 20105405
SGTC_1118 chelidonine 707.474 nM -0.293883901722264 0.389828341132615 no 2063 0.384423309885864 3057 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1556 plumbagin 1.48 µM -0.294304354385882 0.389678698612028 no 2064 0.384262672801951 2915 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_453 enantio-paf c16 10 µM -0.294683888547486 0.389543633361529 no 2065 0.384117686005733 3031 13871343 A lipid and platelet activating factor
SGTC_3222 9128301 49.47 µM -0.294899411915905 0.389466940754802 no 2066 0.384035360600689 2943 4911358
SGTC_1623 st003709 20.3 µM -0.296670126992592 0.388837006389297 no 2067 0.383359182993021 2915 16192618
SGTC_281 1672-3440 14.9 µM -0.2977507149765 0.388452729137306 no 2068 0.382946716486244 3022 6833000
SGTC_724 3910-0327 137 µM -0.297760183748992 0.388449362346998 no 2069 0.382943102788366 3000 2885483
SGTC_1641 st009299 47.1 µM -0.297818173567053 0.388428743219625 no 2070 0.382920971558798 2967 4046054
SGTC_627 1391-0720 175 µM -0.298714642878691 0.388110030486165 no 2071 0.382578891748833 3017 997839
SGTC_85 0868-0259 160.055 µM -0.299205616550013 0.387935511463608 no 2072 0.382391582051609 2984 83173
SGTC_2898 9056270 58.44 µM -0.299571780646627 0.387805371353632 no 2073 0.382251905940592 2925 19154699
SGTC_3099 9120367 49.47 µM -0.300812928255516 0.387364343054151 no 2074 0.381778574716774 2919 24824940
SGTC_3079 9117512 49.47 µM -0.301143982320935 0.387246731122 no 2075 0.381652351847397 2947 7185044
SGTC_2187 6125751 200 µM -0.301723080686535 0.387041022615913 no 2076 0.381431585979412 2962 874498
SGTC_1290 0986-0249 10.2 µM -0.302232132310119 0.386860222453493 no 2077 0.381237555423268 3002 53329
SGTC_165 k038-0023 64.381 µM -0.303719625779788 0.386332049339339 no 2078 0.380670752345038 2956 46368543
SGTC_646 4092-0839 27.3 µM -0.303734370884023 0.386326814760184 no 2079 0.380665135065192 3077 877796
SGTC_925 2064-1272 59.6 µM -0.305039080262599 0.385863718998406 no 2080 0.380168194038926 2954 6815817
SGTC_1677 st019204 53.9 µM -0.305548889241196 0.385682810681118 no 2081 0.379974070384065 3045 3945625
SGTC_2477 5967686 25.23 µM -0.306396888016974 0.385381949081495 no 2082 0.379651238750993 2906 776118
SGTC_1090 efavirenz 20.7 µM -0.307144969482695 0.385116594404935 no 2083 0.379366515081913 2994 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_254 nsc-64875 3.808 µM -0.307323535047891 0.385053262715988 no 2084 0.37929856177077 3099 56993
SGTC_3192 9110362 49.47 µM -0.308428065514254 0.38466158808632 no 2085 0.378878314502125 2925 16649480
SGTC_1796 st049173 110.4 µM -0.30855246601822 0.3846174821194 no 2086 0.378830992063353 3051 94134
SGTC_771 0250-0039 27.3 µM -0.309370340310282 0.384327543523209 no 2087 0.378519914738305 2962 3005115
SGTC_640 3381-0960 37.1 µM -0.3111194053013 0.383707712707632 no 2088 0.377854924710786 3014 1745025
SGTC_1163 k060-0048 49.9 µM -0.311880850638841 0.383437965777566 no 2089 0.3775655380654 2955 6809982
SGTC_3171 9103192 49.47 µM -0.311901381234912 0.38343069346281 no 2090 0.377557736380701 3045 13018434
SGTC_1188 1403-0014 4.57 µM -0.312953449058594 0.383058086717812 no 2091 0.377158014565681 2974 9614867
SGTC_1415 3966-0071 78.1 µM -0.315036329047484 0.382320720640548 no 2092 0.376367035316536 3001 2893185
SGTC_1431 4049-0260 9.09 µM -0.317067523642338 0.381602062578195 no 2093 0.375596183413145 2941 3854841
SGTC_2045 5106652 78.05 µM -0.318033110085298 0.381260570818251 no 2094 0.375229910778441 3081 673349
SGTC_894 0960-0238 55.9 µM -0.318260671789988 0.381180104215582 no 2095 0.375143606931474 3064 6741907 YDL195W SEC31
SGTC_1864 st057645 30.4 µM -0.31911343307683 0.380878610607474 no 2096 0.374820248831451 3033 688666
SGTC_1644 st010134 20.9 µM -0.320330186123232 0.380448553009487 no 2097 0.374359021270384 3077 3818134
SGTC_794 k038-0031 316 µM -0.320693085674507 0.38032031586092 no 2098 0.374221493799525 2985 6624242
SGTC_674 0498-0004 451 µM -0.321025595309966 0.380202829087409 no 2099 0.37409549719694 3035 4231473
SGTC_2423 st077119 87.2 µM -0.321566450460453 0.380011750490148 no 2100 0.373890581760742 2976 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_292 k038-0015 474 µM -0.325104000718554 0.378762694306775 no 2101 0.372551180577463 3094 46368540
SGTC_3251 9135047 49.47 µM -0.325270093750816 0.378704080333014 no 2102 0.372488331502007 3054 17682963
SGTC_2266 7929956 200 µM -0.326554743423464 0.3782508237882 no 2103 0.372002338956699 2929 2967153
SGTC_20 0481-0013 4.944 µM -0.327252799971551 0.378004602165418 no 2104 0.371738344389374 3014 182045
SGTC_101 0490-5701 117.494 µM -0.327436909132836 0.377939670612908 no 2105 0.371668727097135 3026 4661669
SGTC_2762 leflunomide 42.06 µM -0.327567833702632 0.377893498280695 no 2106 0.371619223075136 2978 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_660 4031-1742 102 µM -0.327793837811496 0.377813798959205 no 2107 0.371533773428027 2980 6738706
SGTC_3027 9089541 49.47 µM -0.329681679548504 0.377148263625932 no 2108 0.370820249055955 3078 9943819
SGTC_2961 9083290 32.55 µM -0.331374933109713 0.376551638183985 no 2109 0.370180648390736 3060 17741490
SGTC_2689 tacrolimus 100 µM -0.332378874739769 0.376198033977018 no 2110 0.369801594096677 3056 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2205 7238770 200 µM -0.333352510893844 0.37585520307341 no 2111 0.369434102915211 3116 279867
SGTC_3117 9124945 49.47 µM -0.335085405271591 0.375245269242782 no 2112 0.368780330998188 2935 17592065
SGTC_3136 9095672 49.47 µM -0.335487973334284 0.375103620308186 no 2113 0.368628507741216 2931 17217380
SGTC_1897 st060201 15 µM -0.3356389283645 0.375050509111166 no 2114 0.368571582318913 3007 611878
SGTC_3109 9122853 49.47 µM -0.336195276023974 0.374854787238773 no 2115 0.368361807494392 3032 1234709
SGTC_3340 9146634 11.102 µM -0.337207192858056 0.374498879789378 no 2116 0.367980357702472 3097 4907387
SGTC_124 0136-0217 7.121 µM -0.337292923261041 0.374468731933636 no 2117 0.367948046946113 3164 3976905
SGTC_2491 paeonol 100 µM -0.337987095497829 0.374224648396265 no 2118 0.367686456219412 2944 11092 Increases levels of cortical cytochrome oxidase.
SGTC_406 estrone 100 µM -0.339681170307433 0.373629192787269 no 2119 0.367048321696622 3183 5870 A steroid.
SGTC_3239 9133757 49.47 µM -0.340688851512287 0.373275142730337 no 2120 0.36666891616317 2997 17036923
SGTC_3049 9092223 49.47 µM -0.341812410246895 0.37288050508954 no 2121 0.366246034750143 3105 8623917
SGTC_1709 st033179 39.1045 µM -0.343950429731953 0.372129917929395 no 2122 0.365441782736502 3004 573381
SGTC_1012 4112-3522 18 µM -0.344569435733095 0.371912696138956 no 2123 0.365209043430314 3176 3112398
SGTC_3152 9099253 49.47 µM -0.347378997426151 0.370927277167783 no 2124 0.364153304860623 3078 25236131
SGTC_320 4092-0846 5.34 µM -0.348608685207018 0.370496245145954 no 2125 0.363691553237572 3106 1359356
SGTC_2264 7948757 110.76 µM -0.349317686228289 0.370247798866243 no 2126 0.363425411034785 2960 2971411
SGTC_1787 fluconazole 80 µM -0.351806280353031 0.369376181239423 no 2127 0.362491774129879 3125 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_106 0092-0003 11.579 µM -0.352152385838137 0.369255012575486 no 2128 0.362361991582713 3070 1072148
SGTC_3169 9102970 49.47 µM -0.352552035101629 0.369115114836338 no 2129 0.362212150880875 3055 17027839
SGTC_1164 k060-0068 93.7 µM -0.353775224522949 0.36868704359739 no 2130 0.36175367112227 3028 5963676
SGTC_2376 9072922 81.32 µM -0.353872589335919 0.368652976491302 no 2131 0.361717185047665 3149 17087968
SGTC_2814 7977482 42.97 µM -0.354865238888514 0.368305715946786 no 2132 0.361345275582599 3180 6456762
SGTC_3020 9089140 49.47 µM -0.355701486283386 0.36801325333346 no 2133 0.361032065923505 3119 17217859
SGTC_3023 9089636 49.47 µM -0.357094408213415 0.367526273610641 no 2134 0.360510565244981 3130 17249241
SGTC_187 1488-2104 32.728 µM -0.357742259220054 0.367299850790563 no 2135 0.360268102453651 3099 2852859
SGTC_901 1112-0062 60.1 µM -0.359554570495406 0.36666669636309 no 2136 0.359590130946525 3044 1908457
SGTC_1802 st050112 57.9 µM -0.359609536440418 0.366647498955473 no 2137 0.359569575505993 3044 4662563
SGTC_1555 citronellol 128 µM -0.359696445343717 0.366617145830006 no 2138 0.359537075287533 3124 8842 A terpine precursor.
SGTC_2955 9076254 12.21 µM -0.361936507857814 0.365835087400317 no 2139 0.358699738744141 3141 16459619
SGTC_2368 9071271 200 µM -0.362525267029207 0.365629630086517 no 2140 0.358479772726471 3057 27209959
SGTC_2182 6325192 200 µM -0.363400375510642 0.365324317648263 no 2141 0.358152910651862 3128 736248
SGTC_1197 1601-0112 267 µM -0.364962379707166 0.364779569618396 no 2142 0.357569744373228 3036 7350313
SGTC_306 1672-3436 11.6 µM -0.365335816906145 0.364649373994861 no 2143 0.357430372685292 3149 6797378
SGTC_2346 9031566 143.75 µM -0.365478775544589 0.364599536842782 no 2144 0.357377023667509 3108 4771086
SGTC_3086 9117350 49.47 µM -0.366356070154567 0.364293751213767 no 2145 0.357049697697652 3112 2679265
SGTC_465 cgp-37157 41 µM -0.366391896387896 0.364281265626616 no 2146 0.357036332863792 3102 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2605 digitonin 300 nM -0.366979119068506 0.364076636684314 no 2147 0.356817296792545 3206 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1552 6-methylflavone 10.6 µM -0.367637345086012 0.363847311335168 no 2148 0.356571832338553 3137 689013
SGTC_2185 6113692 200 µM -0.367819069973323 0.363784007134505 no 2149 0.356504074280986 3176 874150
SGTC_2803 7707263 71.43 µM -0.368653363161168 0.363493427300595 no 2150 0.356193057343866 3045 2199229
SGTC_612 0302-0167 22.4 µM -0.368868715840477 0.363418433863062 no 2151 0.356112791340094 3115 235821
SGTC_2585 alliin 100 µM -0.369534243468065 0.363186706643468 no 2152 0.355864776958305 3249 87310 A garlic compound which reacts with lipids.
SGTC_2204 7233102 200 µM -0.371043185319917 0.3626615001981 no 2153 0.355302683325333 3063 2172480
SGTC_1581 himbacine 57.9 µM -0.371106294893723 0.362639539727201 no 2154 0.35527918132078 3049 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_510 ag-490 170 µM -0.371435024259364 0.362525157866985 no 2155 0.355156771411252 3146 5328779
SGTC_3096 9117468 49.47 µM -0.371456841686608 0.362517566895552 no 2156 0.355148647721194 3168 41316311
SGTC_2390 9097792 176.6 µM -0.371586646090717 0.362472404964528 no 2157 0.3551003165849 3074 4497149
SGTC_2528 xanthyletin 44.79 µM -0.371808534875643 0.362395209196096 no 2158 0.355017704316017 3029 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_635 k038-0028 24.7 µM -0.372597606162661 0.362120734291846 no 2159 0.354723977379186 3091 4035102
SGTC_318 1488-0629 67.2 µM -0.372751543960241 0.362067195979012 no 2160 0.354666685040728 3133 3662576
SGTC_2850 9015429 58.44 µM -0.372947677144382 0.36199898636396 no 2161 0.354593693249291 3119 6457570
SGTC_721 1187-1332 279 µM -0.372982550505195 0.361986858846997 no 2162 0.354580715539998 2993 25730
SGTC_2354 9060492 162 µM -0.373851453773464 0.36168473488546 no 2163 0.354257417986893 3220 6471895
SGTC_499 genistein 192 µM -0.374063346636133 0.361611071268613 no 2164 0.354178593777241 3131 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3313 9133968 57.047 µM -0.375899619476032 0.360972914201751 no 2165 0.353495761709082 3095 1494643
SGTC_2196 6573537 42.6665 µM -0.37676759823121 0.360671401405639 no 2166 0.353173161057319 3181 2903087
SGTC_1246 0422-0085 105 µM -0.377048944469741 0.360573687759079 no 2167 0.353068616055524 3212 264295
SGTC_264 promethazine 12.5 mM -0.377374242336032 0.360460720732453 no 2168 0.352947752962286 3179 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3126 9127922 49.47 µM -0.37771181908295 0.360343502464455 no 2169 0.352822343387977 3269 45595682
SGTC_3227 9130768 49.47 µM -0.378182944854975 0.360179933321116 no 2170 0.352647347156833 3068 17720899
SGTC_37 0566-0070 1.56 µM -0.378892036631708 0.359933793527971 no 2171 0.35238401897436 3135 1626686
SGTC_2184 6075246 200 µM -0.379329532417131 0.359781959039567 no 2172 0.352221585904534 3132 2267320
SGTC_415 dibenzyl ketone 100 µM -0.381042327000944 0.359187740589986 no 2173 0.351585920541105 3132 7593
SGTC_2733 amorolfine 100 µM -0.383273210680169 0.358414292579382 no 2174 0.350758600124707 3136 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2309 7664088 163.95 µM -0.383331688725651 0.358394026018342 no 2175 0.350736923109858 3258 704922
SGTC_899 1083-0020 478 µM -0.383439857631313 0.358356539296057 no 2176 0.350696827650795 3244 767123
SGTC_291 SEC14.278 35.5 µM -0.384230513654259 0.358082573167535 no 2177 0.350403802123419 3194 1068044
SGTC_3120 9124077 49.47 µM -0.386015112691752 0.35746446974284 no 2178 0.349742738159691 3125 18774327 YGL155W CDC43
SGTC_1653 st012112 65 µM -0.386406672963346 0.357328901125141 no 2179 0.349597754435596 3242 720429
SGTC_48 0382-0018 55 µM -0.387882331231115 0.356818150760205 no 2180 0.349051557057173 3332 762596
SGTC_1187 1391-0724 117 µM -0.388218011182989 0.356702002020851 no 2181 0.348927352709171 3139 6997986
SGTC_247 mechlorethamine 29.705 µM -0.388430106453164 0.356628621709404 no 2182 0.348848884054677 3071 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1714 st033236 13.627 µM -0.388685300507683 0.356540337197205 no 2183 0.34875447875862 3269 2916566
SGTC_668 1682-0499 62.6 µM -0.389539597917233 0.356244848533365 no 2184 0.348438512137124 3140 682214
SGTC_1298 1079-1278 263 µM -0.389565416992839 0.35623591944491 no 2185 0.348428964444913 3132 2840950
SGTC_1905 st060207 84.5 µM -0.390272098858269 0.355991556153539 no 2186 0.348167676322248 3054 1948547
SGTC_51 1013-0126 23.419 µM -0.390407214768222 0.355944841199523 no 2187 0.348117726849741 3361 1627850
SGTC_2269 7935389 174.42 µM -0.391303050385725 0.355635169865213 no 2188 0.347786622194404 3064 97605
SGTC_111 0083-0039 52.457 µM -0.393069978239683 0.355024659857106 no 2189 0.347133898525845 3037 759313
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.393313039928022 0.354940706104943 no 2190 0.347044144134401 3223 756377
SGTC_1501 4491-0275 38.4 µM -0.393421673029332 0.354903186399283 no 2191 0.347004032409259 3198 5104718
SGTC_3297 9117502 71.43 µM -0.394914778966966 0.354387640124247 no 2192 0.346452891315784 3189 7453720
SGTC_2164 5685496 200 µM -0.396175159326664 0.353952657907245 no 2193 0.345987907627125 3226 759046
SGTC_36 0335-0881 14.2 µM -0.396365745486973 0.353886899421286 no 2194 0.345917616139351 3146 23828853
SGTC_3116 9124943 49.47 µM -0.396714570566474 0.353766554600164 no 2195 0.345788977142698 3119 41905195 YPL160W CDC60
SGTC_1771 st048882 4.1505 µM -0.396783423642988 0.353742801981781 no 2196 0.345763587749613 3088 4580403
SGTC_468 gf-109203x 121 µM -0.397682861376945 0.353432570407902 no 2197 0.345431986171711 3137 2396 A protein kinase C inhibitor.
SGTC_1022 4477-0945 21.3 µM -0.401505041765368 0.352115322526531 no 2198 0.344024163460734 3112 4648966
SGTC_2721 ifenprodil 61.44 µM -0.402431526962265 0.351796291836386 no 2199 0.343683235821147 3247 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_819 1013-0258 27.7 µM -0.403224069559027 0.351523466413115 no 2200 0.343391697172763 3129 5753198
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.40475881930341 0.350995360595411 no 2201 0.342827400880279 3221 6708760
SGTC_208 k072-0098 12.366 µM -0.405476489335196 0.350748509721081 no 2202 0.342563648373375 3135 5948901
SGTC_2763 lisinopril 49.32 µM -0.406750997231433 0.350310283376479 no 2203 0.34209544037255 3188 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1610 st001799 48.1 µM -0.407563745043698 0.350030932434979 no 2204 0.341796992958848 3056 621897
SGTC_2936 9038235 15.59 µM -0.407940397888826 0.349901499946287 no 2205 0.341658716568056 3086 4749415
SGTC_2504 purpurogallin 52.29 µM -0.411409608148512 0.348710166864489 no 2206 0.340386104897236 3115 5281571 An antioxidant.
SGTC_2563 tomatine 8.54 µM -0.412021164373666 0.348500311526932 no 2207 0.340161955322941 3335 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2981 9013952 38.96 µM -0.412797207253485 0.348234079387159 no 2208 0.339877598873782 3149 2996344
SGTC_3008 9078912 71.4286 µM -0.417151147900169 0.346741790167992 no 2209 0.338283927555582 3151 16648731
SGTC_1764 st044502 93.5 µM -0.418348014249772 0.346331985929032 no 2210 0.337846344685086 3246 8407
SGTC_1705 st027868 56.3335 µM -0.418678803695487 0.346218756095427 no 2211 0.337725444319245 3204 292948
SGTC_2812 7970281 58.44 µM -0.419328702034251 0.345996334740458 no 2212 0.337487961488661 3285 2233435
SGTC_481 bay k-8644 50 µM -0.422013497472377 0.345078053516617 no 2213 0.33650758276508 3160 2303 A calcium channel antagonist.
SGTC_2122 5258151 111.688 µM -0.422654374749053 0.344858988671814 no 2214 0.33627372421202 3157 2173356
SGTC_3246 9135460 32.98 µM -0.42288369647516 0.344780614485343 no 2215 0.33619005922529 3223 41446951
SGTC_3207 9114163 49.47 µM -0.423736015392044 0.344489379942104 no 2216 0.335879173128364 3379 849233
SGTC_952 1185-0122 232 µM -0.42389685790819 0.344434430920793 no 2217 0.33582051788303 3135 678600
SGTC_269 exalamide 29 µM -0.424528246809755 0.344218759738434 no 2218 0.335590304804866 3151 3316 A derivative of salicylamide.
SGTC_780 0109-0199 192 µM -0.425682757502655 0.343824530520192 no 2219 0.335169513933362 3307 610414
SGTC_1395 3486-0190 4.35 µM -0.428404573286332 0.342895788199062 no 2220 0.33417829783405 3316 6748079
SGTC_3065 9113888 49.47 µM -0.430406899487269 0.34221315644342 no 2221 0.333449838668375 3338 16648368
SGTC_370 0180-0345 38.7 µM -0.430821388646457 0.342071913366711 no 2222 0.333299123159781 3064 3989527
SGTC_181 1447-1644 8.07 µM -0.431143553821148 0.341962146260832 no 2223 0.333181996853085 3238 534600
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.43340244531788 0.341192879449209 no 2224 0.332361212177125 3200 6708561
SGTC_216 k038-0035 28.382 µM -0.433497056327252 0.341160673983889 no 2225 0.332326852078389 3224 4444231 YPR107C YTH1
SGTC_3269 9137823 49.47 µM -0.435765840719369 0.340388729732806 no 2226 0.331503315059458 3138 17682936
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.437751495092898 0.339713667491802 no 2227 0.330783217958861 3121 6708514
SGTC_555 4296-0685 37 µM -0.438034088069172 0.339617636168905 no 2228 0.330680786484556 3232 2908540 YHR072W ERG7
SGTC_573 3702-0553 84.7 µM -0.440040763297814 0.338936023445008 no 2229 0.329953791980919 3191 1222756
SGTC_586 0957-0265 8.15 µM -0.440916657540499 0.338638671184535 no 2230 0.329636666970751 3239 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1756 st041558 35.5 µM -0.442041565388682 0.338256930252361 no 2231 0.329229564094797 3342 3955792
SGTC_2663 amphotericin b 100 µM -0.443194516957686 0.337865845058237 no 2232 0.32881252224661 3248 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2525 harmine 47.85 µM -0.443813138125282 0.337656078695214 no 2233 0.328588844427337 3190 5280953 A monoamine oxidase inhibitor
SGTC_1295 1013-0063 9.78 µM -0.444058090679383 0.337573032414251 no 2234 0.328500292725323 3313 6826038
SGTC_1838 st055369 84.5 µM -0.445008901554605 0.337250753906702 no 2235 0.328156660629775 3230 676036
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.44539665822034 0.337119357568431 no 2236 0.328016563397629 3211 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2799 7812892 81.82 µM -0.448157948851659 0.336184234024694 no 2237 0.327019604341057 3318 20205235
SGTC_1793 st048256 72.231 µM -0.448956612556102 0.335913951524004 no 2238 0.326731477849609 3229 672022
SGTC_2393 9031399 185.94 µM -0.450694300647704 0.335326179125703 no 2239 0.326104945303882 3332 1526623 YDL150W RPC53
SGTC_2545 solidagenone 89.61 µM -0.451847419307529 0.334936359413544 no 2240 0.325689452972776 3161 6708572 An anti ulcer agent
SGTC_1843 st055809 45.5 µM -0.452848590123882 0.334598050869047 no 2241 0.325328886083499 3290 16413835
SGTC_842 0271-0008 11.1 µM -0.453075176610082 0.334521502989473 no 2242 0.325247304712382 3326 1221709
SGTC_444 curcumin 90.4 µM -0.453533171683466 0.334366799182228 no 2243 0.325082431371195 3312 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1093 fluphenazine 7.97 µM -0.453595563285818 0.334345726419008 no 2244 0.325059973709423 3219 6602611 An atypical antipsychotic.
SGTC_2292 7671323 168.05 µM -0.45473689484787 0.333960333866917 no 2245 0.324649267213087 3339 937504
SGTC_357 1325-0123 420 µM -0.455288026788243 0.333774296214126 no 2246 0.324451019460596 3289 1098503
SGTC_1074 carmofur 3.8 µM -0.4553103603485 0.333766758257645 no 2247 0.324442986900606 3240 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1381 2324-0066 62.1 µM -0.456213410888743 0.333462019569524 no 2248 0.324118261302299 3282 10885928
SGTC_989 1501-0895 10.3 µM -0.458637039957613 0.332644698024516 no 2249 0.323247416597279 3328 2830112
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.458698054444996 0.332624132321879 no 2250 0.323225505683882 3281 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1024 4507-0395 26 µM -0.458752887189708 0.332605650683335 no 2251 0.32320581521935 3353 4201836
SGTC_2656 pseudo-anisatin 100 µM -0.460912288672798 0.331878138002279 no 2252 0.322430767438438 3239 6708809 A neurotoxin.
SGTC_2386 9075165 157.42 µM -0.461008685063632 0.331845676347787 no 2253 0.322396187007484 3273 16452277
SGTC_3052 9092717 49.47 µM -0.461809797661517 0.331575949127095 no 2254 0.322108862084683 3330 25237534
SGTC_1987 st072290 61.9 µM -0.462290547308594 0.331414127065776 no 2255 0.32193648870629 3245 54697379
SGTC_1649 st011737 51.3 µM -0.46234277454574 0.331396549084281 no 2256 0.321917764872203 3257 1761035
SGTC_3031 9088762 49.47 µM -0.462714304276385 0.331271515037359 no 2257 0.3217845818849 3162 205253
SGTC_615 k087-0205 167 µM -0.463121304793314 0.331134565293116 no 2258 0.321638709892895 3230 9642773
SGTC_2514 salinomycin 42.74 µM -0.463125839332092 0.331133039614072 no 2259 0.321637084835523 3341 23682228 A polyether potassium ionophore.
SGTC_2915 7971052 15.16 µM -0.46344551430096 0.331025489678001 no 2260 0.321522530482232 3254 5741558
SGTC_3203 9113543 49.47 µM -0.464126493227227 0.330796430835956 no 2261 0.321278560770979 3314 17018012
SGTC_2881 9058953 51.95 µM -0.464451548053704 0.330687115445102 no 2262 0.321162132756454 3187 17122249
SGTC_544 k015-0020 52.4 µM -0.464537390173561 0.330658249294509 no 2263 0.321131388791784 3259 3008304
SGTC_2643 anethole 100 µM -0.46474632830915 0.330587993826012 no 2264 0.321056563672877 3286 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2107 5363541 170.161 µM -0.468112087808293 0.329457080862422 no 2265 0.319852217725197 3319 244052
SGTC_3157 9099274 49.47 µM -0.470757884104553 0.328569172476981 no 2266 0.318906821625732 3360 17217662
SGTC_1205 4161-2785 76 µM -0.470917142490865 0.328515757427175 no 2267 0.318849952906598 3303 3498106
SGTC_2876 9059903 25.97 µM -0.471304996480064 0.328385686378819 no 2268 0.318711474058268 3309 6916095
SGTC_3047 9092122 49.47 µM -0.472201812400921 0.328085009082261 no 2269 0.318391373104039 3277 17173831
SGTC_2839 9003951 25.97 µM -0.473260710044152 0.327730133699328 no 2270 0.318013594736422 3319 2990634
SGTC_2800 7887935 81.82 µM -0.474514360706313 0.327310190531017 no 2271 0.317566579883763 3345 2961002
SGTC_2965 9082772 38.63 µM -0.475348516292359 0.327030889245891 no 2272 0.317269291859458 3394 16459634
SGTC_3 0833-0587 95.581 µM -0.475621201826815 0.326939606629398 no 2273 0.317172133931132 3281 5382644
SGTC_987 1497-1013 404 µM -0.475878258383789 0.326853565359104 no 2274 0.317080556149052 3336 1676435
SGTC_3264 9137442 49.47 µM -0.475994509735435 0.326814657046056 no 2275 0.31703914465746 3436 17015726
SGTC_9 0092-0002 10.449 µM -0.476498748791833 0.326645914435635 no 2276 0.316859549264022 3312 759368
SGTC_2680 butyl paraben 22.24 µM -0.476898287350152 0.326512234817518 no 2277 0.316717275801211 3309 7184 An antifungal and steroid mimetic.
SGTC_741 4582-0002 126 µM -0.477434343913713 0.326332913314742 no 2278 0.316526431618897 3226 2912688
SGTC_1662 st014054 52 µM -0.478051355032907 0.326126560600518 no 2279 0.31630682685903 3286 2838777
SGTC_2425 5628681 7.85 µM -0.478289018292657 0.326047090882855 no 2280 0.316222255733881 3302 5714958
SGTC_1184 1269-1718 139 µM -0.479652299403306 0.325591390373126 no 2281 0.315737325702377 3378 5403821
SGTC_694 1315-0438 43.2 µM -0.481370256699884 0.325017504232182 no 2282 0.315126686016051 3243 6793154
SGTC_2262 9014885 67.46 µM -0.481581618113888 0.32494692728074 no 2283 0.315051593458225 3257 6457424
SGTC_287 k060-0039 29.6 µM -0.482173244836066 0.324749407078346 no 2284 0.314841440754877 3366 5861974
SGTC_943 3253-1379 105 µM -0.485155070249042 0.32375464717948 no 2285 0.313783175154467 3386 668464
SGTC_2882 9058044 58.44 µM -0.485378858007376 0.323680040515689 no 2286 0.313703813322481 3307 18076804
SGTC_865 0488-0499 301 µM -0.486702721256013 0.323238834228669 no 2287 0.313234508250136 3397 9634651
SGTC_1229 0139-0193 12.2 µM -0.488091357723838 0.3227763078835 no 2288 0.312742566136305 3390 3090752
SGTC_816 0325-0417 81.3 µM -0.488407996843545 0.322670880223339 no 2289 0.312630439345509 3334 68101
SGTC_2198 6589944 200 µM -0.488501069852566 0.322639893491855 no 2290 0.312597484056004 3315 5290268
SGTC_2684 capsaicin 100 µM -0.488626116655102 0.322598263686886 no 2291 0.312553209845074 3371 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2092 5303694 80.6725 µM -0.488672546328941 0.322582807174302 no 2292 0.312536771591407 3255 1963699
SGTC_2593 nobiletin 86.24 µM -0.491205153344572 0.321740163350588 no 2293 0.311640677233543 3297 72344 An anti-infammatory.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.491957076982235 0.321490161024766 no 2294 0.311374843719528 3345 616764
SGTC_1902 st060212 70.5 µM -0.492248189430097 0.321393392591396 no 2295 0.311271950826403 3386 688944
SGTC_2872 9044037 25.97 µM -0.493448209430791 0.320994623025558 no 2296 0.310847962785079 3298 6465195
SGTC_3194 9111903 49.47 µM -0.496524223758874 0.319973399323895 no 2297 0.309762300500299 3419 17087251
SGTC_246 cycloheximide 667 µM -0.497956253413757 0.319498435929006 no 2298 0.309257438295093 3244 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2909 7941780 10.49 µM -0.498084544785502 0.319455899773577 no 2299 0.309212226711596 3422 1243215
SGTC_2879 9041815 71.43 µM -0.500125839860286 0.318779410003801 no 2300 0.308493236268341 3323 4942971
SGTC_1306 1185-0270 9.02 µM -0.500749412620686 0.318572876805029 no 2301 0.308273745976988 3364 1548076
SGTC_3025 9087895 49.47 µM -0.50283743294694 0.317881715300775 no 2302 0.307539286594127 3392 17173641
SGTC_399 oxolinic acid 75 µM -0.504041803244993 0.317483341411738 no 2303 0.30711600069625 3277 4628 A DNA gyrase inhibitor.
SGTC_1325 1431-0015 227 µM -0.504432511959616 0.317354150655319 no 2304 0.306978738050403 3249 1103340
SGTC_2774 tamoxifen 10.92 µM -0.505470657628061 0.317010988160224 no 2305 0.306614151208882 3382 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2100 5377183 190 µM -0.506700988493532 0.316604501929648 no 2306 0.306182318442587 3336 2844202
SGTC_3276 9139060 49.47 µM -0.507293405807888 0.316408853445696 no 2307 0.305974482363766 3364 4870619
SGTC_2195 6536160 144.242 µM -0.508011703508997 0.316171701304551 no 2308 0.305722567798998 3256 3834386
SGTC_1868 st057644 42.7 µM -0.508246366849687 0.316094241571481 no 2309 0.305640288808049 3271 688665
SGTC_3238 9133470 49.47 µM -0.509703748854609 0.315613356979758 no 2310 0.305129513106185 3406 3534688
SGTC_907 3448-6986 75.5 µM -0.510225903395209 0.315441140305611 no 2311 0.304946603331765 3437 590582
SGTC_797 k781-0471 270 µM -0.510759372295312 0.315265233331319 no 2312 0.304759780477154 3284 23738129
SGTC_1513 0337-0559 19 µM -0.510768966305174 0.315262070168799 no 2313 0.304756421083897 3260 775073
SGTC_1872 amphotericin b 148 nM -0.511424064596488 0.315046115112771 no 2314 0.304527073905815 3361 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1797 st048695 56.8 µM -0.511664958213381 0.31496671972213 no 2315 0.304442757371381 3373 592262 YIL048W NEO1
SGTC_3226 9131256 49.47 µM -0.512456005937122 0.314706060870054 no 2316 0.30416595140502 3333 17178073
SGTC_1363 1636-0063 10.4 µM -0.51383409133254 0.314252187221108 no 2317 0.303683995364218 3328 6072185
SGTC_1740 st038286 13.222 µM -0.514281387478855 0.314104930147916 no 2318 0.30352763635945 3439 716786
SGTC_927 2425-1185 123 µM -0.515515486475228 0.31369879844389 no 2319 0.303096425309559 3246 730375
SGTC_3054 9094397 49.47 µM -0.516978066970079 0.313217767597564 no 2320 0.302585734850708 3328 2598354
SGTC_3045 9092950 49.47 µM -0.517054631047856 0.313192595036903 no 2321 0.302559011532583 3444 44120432
SGTC_133 0724-0033 378.92 µM -0.51712847418552 0.313168317885281 no 2322 0.302533238911973 3236 280309
SGTC_1686 st019653 115.5 µM -0.517851651776852 0.312930604116389 no 2323 0.302280888589325 3397 97252
SGTC_2374 9071832 200 µM -0.520263459054554 0.312138387898727 no 2324 0.301439980328976 3403 17381698
SGTC_3353 9151644 39.2805 µM -0.522200695770013 0.311502684129773 no 2325 0.300765300819836 3416 4909158
SGTC_2332 7982454 138.89 µM -0.522708677375041 0.311336082935013 no 2326 0.30058849938857 3404 2981748
SGTC_921 1561-0023 372 µM -0.522742735586689 0.311324914347651 no 2327 0.300576647211703 3372 24050882
SGTC_3129 9127257 49.47 µM -0.523826855812668 0.310969493476933 no 2328 0.300199486258485 3266 837894
SGTC_628 1636-0253 16 µM -0.524389964200272 0.310784952045829 no 2329 0.300003667648386 3371 4456143
SGTC_1274 0865-0114 173 µM -0.52490691173273 0.310615580306668 no 2330 0.299823952183106 3339 870624
SGTC_1616 st002734 56.1 µM -0.525838568967342 0.31031043520439 no 2331 0.299500187114632 3287 4026101
SGTC_263 alizarin 107.927 µM -0.526554760953331 0.310075950025384 no 2332 0.299251407293175 3379 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1841 st054148 70 µM -0.527029896544142 0.309920430628912 no 2333 0.299086413707438 3365 675442
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.527404072259181 0.309797980930714 no 2334 0.298956508098498 3399 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_132 0417-1715 25.805 µM -0.528272630670623 0.309513824932727 no 2335 0.298655062482902 3464 6769098
SGTC_879 0831-1030 162 µM -0.530302149090891 0.308850295359701 no 2336 0.297951228446087 3431 1549252
SGTC_954 1189-0853 2.85 µM -0.531384536895876 0.308496674859333 no 2337 0.297576167357919 3408 2828194
SGTC_947 3447-0010 211 µM -0.531718629413676 0.308387561321894 no 2338 0.297460443609156 3416 748350
SGTC_460 trequinsin 123 µM -0.53476510822622 0.307393372930721 no 2339 0.296406146623281 3450 5537 A vasodilator.
SGTC_1994 st072947 40.9 µM -0.535269571078345 0.30722888265835 no 2340 0.296231732256504 3434 5286565 YDL195W SEC31
SGTC_1613 st002381 52.1 µM -0.535575714450879 0.307129077350655 no 2341 0.296125908367203 3416 551167
SGTC_1255 0566-0045 221 µM -0.535690462377402 0.30709167224465 no 2342 0.296086248180013 3461 2788469
SGTC_1061 3448-9325 110 µM -0.535992721158701 0.30699315265055 no 2343 0.295981790511794 3426 723482
SGTC_1507 4075-3230 155 µM -0.537856654131775 0.306385922038722 no 2344 0.295338007752045 3377 659771
SGTC_2178 5812956 200 µM -0.538585577517459 0.306148598378458 no 2345 0.295086420690774 3400 5403383
SGTC_322 k048-0136 19.3 µM -0.538709276056285 0.306108332544425 no 2346 0.295043736081861 3423 6823282
SGTC_2829 7992743 58.44 µM -0.539422488837325 0.305876216186231 no 2347 0.294797683503696 3393 16462845
SGTC_902 1120-0002 2.07 µM -0.53981699308659 0.305747857559249 no 2348 0.29466162341167 3421 3280475
SGTC_1529 apigenin 74 µM -0.54271612888569 0.304805307535041 no 2349 0.293662633734512 3513 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2014 4013930 200 µM -0.542994546582915 0.304714858011515 no 2350 0.293566778603502 3449 64556
SGTC_3254 9136651 49.47 µM -0.544809824251786 0.30412542178044 no 2351 0.29294216058215 3377 16454030
SGTC_1087 pterostilbene 9.05 µM -0.546030048681418 0.303729490222003 no 2352 0.29252264106518 3462 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1819 st053448 58.6 µM -0.547728419871642 0.30317879554328 no 2353 0.291939197411206 3348 2857616
SGTC_597 k018-0003 82.8 µM -0.548076522641679 0.303065978826004 no 2354 0.291819680167873 3461 6786234
SGTC_2786 7743617 45.45 µM -0.549439769030943 0.302624344862013 no 2355 0.291351844149444 3338 583674
SGTC_914 3820-6779 408 µM -0.549633491649401 0.302561610365499 no 2356 0.291285391241484 3355 2893481
SGTC_1435 4092-0789 56.7 µM -0.5500561460788 0.302424759579419 no 2357 0.291140432132945 3447 2248285
SGTC_1371 2421-0008 32.7 µM -0.55256316241459 0.301613586978817 no 2358 0.290281286254369 3352 2827552
SGTC_2424 5537928 59.2 µM -0.55315950272658 0.301420778710684 no 2359 0.290077097439805 3383 5382802
SGTC_3162 9099653 49.47 µM -0.556094757473251 0.300472564193527 no 2360 0.289073039390965 3445 25237511
SGTC_2650 prasterone 100 µM -0.556205531953139 0.300436805631634 no 2361 0.289035178965008 3420 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_228 caffeine 993.056 µM -0.556468074136942 0.300352063366415 no 2362 0.288945456793285 3469 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1 0258-0098 57.368 µM -0.55671815292667 0.3002713540291 no 2363 0.2888600060981 3377 6790032 YDR047W HEM12
SGTC_158 k038-0087 26.446 µM -0.55767288790907 0.299963317223329 no 2364 0.288533887271655 3389 X158
SGTC_2764 methyldopa 94.69 µM -0.557729074490346 0.299945193575616 no 2365 0.288514700439173 3513 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3257 9139206 32.98 µM -0.558559372048644 0.299677429049356 no 2366 0.288231237014725 3436 4910041
SGTC_3274 9138298 49.47 µM -0.558602658956394 0.299663472327425 no 2367 0.28821646247635 3424 17015756
SGTC_1901 st060216 58.6 µM -0.564533029735089 0.297754171342303 no 2368 0.286195713993993 3463 688792
SGTC_1971 st069429 63.5 µM -0.564658107197343 0.297713962089459 no 2369 0.286153166939339 3462 1246522 YGL099W LSG1
SGTC_2442 5158906 48.48 µM -0.564895881980499 0.297637530319353 no 2370 0.286072292414725 3473 1893835
SGTC_2119 5528445 120.635 µM -0.566632920598951 0.297079437954734 no 2371 0.285481801823892 3482 791935
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.566914053572195 0.296989157877433 no 2372 0.28538628779429 3418 15053
SGTC_1908 st060353 56.5 µM -0.567814704863448 0.296700016763687 no 2373 0.285080396915519 3534 4227716
SGTC_1179 1021-1431 9.29 µM -0.568425668630023 0.296503949063017 no 2374 0.284872982491852 3425 2840958
SGTC_1437 4092-1038 11.6 µM -0.569643656889436 0.296113255103242 no 2375 0.284459705929944 3434 3977136
SGTC_251 melphalan 456.522 µM -0.570178671777692 0.295941713142683 no 2376 0.284278260188073 3473 460612 A DNA alkylator.
SGTC_2161 5662504 8.5105 µM -0.570219636793616 0.295928580399971 no 2377 0.284264369532387 3411 2859334
SGTC_2307 7538926 6.34 µM -0.57037698696606 0.295878138886521 no 2378 0.284211017338295 3405 96582
SGTC_806 3966-4455 5.86 µM -0.570833917456657 0.295731683737797 no 2379 0.284056114596164 3379 714982
SGTC_1932 st074806 40.9 µM -0.571365426342759 0.295561366678322 no 2380 0.283875980066673 3584 17251235
SGTC_743 1275-0778 158 µM -0.572075320038821 0.295333958242462 no 2381 0.283635474173022 3457 2849257 YMR203W TOM40
SGTC_2589 lobaric acid 100 µM -0.572466434079402 0.29520870257918 no 2382 0.283503009808071 3391 73157 A novel microtubule depolymerizer.
SGTC_909 3448-9333 149 µM -0.573284983509625 0.294946638392728 no 2383 0.283225875585901 3424 3344074
SGTC_2022 5136654 200 µM -0.573301532367997 0.294941341268477 no 2384 0.283220274020997 3456 1713771
SGTC_2817 7995342 71.43 µM -0.574297874921047 0.294622502772891 no 2385 0.282883123487916 3344 18879975
SGTC_1761 st044296 37 µM -0.576664425944375 0.293865823442479 no 2386 0.282083084114477 3458 1826700
SGTC_1114 scopoletin 1.73284 µM -0.576941724084585 0.293777219200777 no 2387 0.281989411693115 3505 5280460 A coumarin with genotoxic properties.
SGTC_324 1315-0088 19.6 µM -0.576993579943249 0.293760651226054 no 2388 0.281971896239556 3452 6787421
SGTC_2306 7482397 179.52 µM -0.577975860027104 0.293446893907712 no 2389 0.281640208618833 3505 891448
SGTC_1875 nocodazole 6 µM -0.57804320728469 0.293425387711717 no 2390 0.281617474288321 3516 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_964 1287-0107 19.4 µM -0.579419073858416 0.292986188153393 no 2391 0.281153218534095 3516 51516812 YPR165W RHO1
SGTC_1376 2910-0861 41.3 µM -0.580118427115898 0.292763059916333 no 2392 0.280917379021734 3487 1112859
SGTC_1261 0712-0010 12.7 µM -0.581050530970592 0.292465795467535 no 2393 0.280603198882042 3533 2840123
SGTC_1424 4048-1941 275 µM -0.581310088277241 0.292383043020672 no 2394 0.280515741317253 3533 X1424
SGTC_121 0557-0495 61.343 µM -0.582818926243571 0.291902208785598 no 2395 0.280007601351079 3503 3104427
SGTC_525 k781-2675 26.7 µM -0.583144719058771 0.291798433982806 no 2396 0.279897940853851 3527 3651118 YDL195W SEC31
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.583286823031709 0.291753174981251 no 2397 0.279850115776059 3541 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2258 7960471 200 µM -0.583769119809398 0.291599591634562 no 2398 0.279687828404928 3447 2974708
SGTC_1821 st053465 65.6 µM -0.584570961677981 0.291344335308874 no 2399 0.27941811887954 3451 675086
SGTC_2313 7726885 200 µM -0.584695710056822 0.291304632598182 no 2400 0.279376169563151 3468 726423
SGTC_1520 flindersine 88 µM -0.585259516633182 0.291125225702789 no 2401 0.279186615685861 3576 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_957 1187-1561 14.1 µM -0.587023690731763 0.290564187709987 no 2402 0.278593897934154 3485 1538454
SGTC_591 4299-0174 154 µM -0.587080838908356 0.290546022060242 no 2403 0.278574707848567 3413 5509088
SGTC_903 1134-0042 114 µM -0.587921408976419 0.290278892073771 no 2404 0.278292522822578 3431 701009
SGTC_657 3534-0529 86.7 µM -0.587992207327416 0.290256397879244 no 2405 0.278268761703992 3504 1049549
SGTC_604 1000-0114 314 µM -0.588041336026369 0.290240789090057 no 2406 0.278252273866804 3528 1572745
SGTC_509 pifithrin 175 µM -0.590211528514333 0.289551685006901 no 2407 0.277524422028408 3548 4817 A p53 inhibitor.
SGTC_1380 2291-0730 164 µM -0.592904770781854 0.288697566084332 no 2408 0.276622442522726 3448 2999191
SGTC_966 1300-0360 30.2 µM -0.593114431018073 0.288631125485189 no 2409 0.276552286646479 3463 70588
SGTC_80 0159-0065 512.242 µM -0.594473648090694 0.288200569124102 no 2410 0.276097681211294 3492 1548079
SGTC_1286 0929-0070 131 µM -0.595072094577218 0.288011096590093 no 2411 0.275897640444198 3553 1420408
SGTC_991 3996-0057 64.7 µM -0.597764652975793 0.28715934116052 no 2412 0.274998489491624 3493 715343
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.598998385003778 0.286769465042869 no 2413 0.274586980764237 3382 4000243
SGTC_2399 5884133 200 µM -0.599495549597296 0.286612425224487 no 2414 0.274421238469349 3484 722445
SGTC_2375 9072683 200 µM -0.5999487013674 0.286469323315782 no 2415 0.274270211979615 3575 16798029
SGTC_2724 maprotiline 69.64 µM -0.601231275221469 0.286064480054004 no 2416 0.273842978174062 3527 4011 A tricyclic antidepressant.
SGTC_2420 aureobasidin a 50 nM -0.602099110260551 0.285790703014623 no 2417 0.273554083378063 3582 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_714 4296-0578 26.1 µM -0.602630771873145 0.285623040619266 no 2418 0.273377172353767 3508 1589775
SGTC_2903 5923464 63.88 µM -0.60266835762108 0.285611189519907 no 2419 0.273364667796589 3535 2876576
SGTC_1519 esterone 74 µM -0.603239920294901 0.285430999890957 no 2420 0.273174547168765 3444 698 A steroid.
SGTC_1152 3909-8331 15.9 µM -0.604141959867423 0.285146734997756 no 2421 0.272874632360837 3490 16001939
SGTC_787 4152-0075 138 µM -0.604661291887344 0.284983136155459 no 2422 0.272702036256884 3466 9566539
SGTC_3243 9134147 49.47 µM -0.607125488023148 0.284207481163684 no 2423 0.271883818237278 3560 24282180
SGTC_821 1114-0266 29.2 µM -0.607388174048309 0.284124855059507 no 2424 0.271796667386522 3522 3123235
SGTC_1961 st076550 68.7 µM -0.607697733740504 0.284027499910713 no 2425 0.271693983194225 3511 1579337
SGTC_1747 st037496 66.6 µM -0.608306079334858 0.283836224434363 no 2426 0.271492244870572 3511 723305
SGTC_483 fpl-64176 144 µM -0.609528004091172 0.283452214378226 no 2427 0.27108725825871 3548 3423
SGTC_1945 st075991 56.6 µM -0.610115781657661 0.283267584308542 no 2428 0.270892556552565 3459 1084980
SGTC_2566 crystal violet carbinol 226 nM -0.611025016178026 0.282982093288925 no 2429 0.270591509552704 3500 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1467 k284-1082 293 µM -0.611127966894892 0.282949776447613 no 2430 0.27055743316765 3530 3334705
SGTC_1002 4049-0206 172 µM -0.612291674385385 0.282584605028176 no 2431 0.270172398537366 3539 4662749
SGTC_1569 carminic acid 40.6 µM -0.6123027943568 0.282581116674104 no 2432 0.270168720606853 3556 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_294 k038-0071 157 µM -0.612378318463278 0.28255742518034 no 2433 0.270143741671482 3531 24152826
SGTC_119 0121-0043 24.815 µM -0.612609830734185 0.282484807014348 no 2434 0.270067178218491 3608 1092378
SGTC_1716 st033144 30.6155 µM -0.612677826617844 0.282463480535233 no 2435 0.270044693353739 3574 674617
SGTC_2115 tiliquinol 12.7705 µM -0.612743551917984 0.282442866946245 no 2436 0.270022960215369 3485 71208 A bioactive hydroxyquinoline.
SGTC_2377 9073351 62.6 µM -0.615345053057622 0.2816275332959 no 2437 0.269163435132733 3474 7337946 YHR072W ERG7
SGTC_25 0118-0223 35.662 µM -0.615392750979884 0.281612594943689 no 2438 0.269147688762734 3578 5333628
SGTC_373 0844-0104 25.9 µM -0.615873757943705 0.281461971347655 no 2439 0.268988921232776 3556 5375804
SGTC_851 0394-0702 453 µM -0.616226506322495 0.281351535642852 no 2440 0.268872518318033 3565 762646
SGTC_1329 1447-1697 50.6 µM -0.616510785256834 0.281262551038217 no 2441 0.268778727943833 3534 2840515
SGTC_2750 bromebric acid 70.15 µM -0.616827141159111 0.281163541721808 no 2442 0.268674373938966 3559 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3208 9114115 49.47 µM -0.619866914099165 0.280213048569348 no 2443 0.267672705020305 3492 650895
SGTC_1820 st053765 18.6 µM -0.621032023686103 0.279849148732757 no 2444 0.267289276549004 3533 3690829
SGTC_2316 5844804 197.44 µM -0.621750712772498 0.279624794218862 no 2445 0.267052899859033 3571 776813
SGTC_2781 5567276 71.43 µM -0.626044692809881 0.278286156571933 no 2446 0.26564281360401 3569 2853274
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.626898359577164 0.278020400828954 no 2447 0.265362931326533 3492 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_314 1671-0008 2.74 µM -0.627928509618442 0.277699868890413 no 2448 0.265025386820014 3502 3913060
SGTC_1127 asiatic acid 681.4 nM -0.630049906536019 0.277040363798089 no 2449 0.264330966298636 3527 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_753 1322-0200 289 µM -0.630191809963702 0.276996275881312 no 2450 0.264284548542667 3607 5403907
SGTC_257 daunorubicin 18.5 µM -0.630475091382132 0.276908273568847 no 2451 0.264191897319911 3572 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_6 0844-0013 19.835 µM -0.631517153384289 0.276584671406868 no 2452 0.263851218515821 3655 1584900
SGTC_2210 7115885 190.385 µM -0.632360322324603 0.276322969286231 no 2453 0.263575727365338 3577 2927039
SGTC_1125 tnp00248 1.32998 µM -0.633212113164059 0.276058714515155 no 2454 0.263297568265078 3608 24207736
SGTC_200 k038-0079 37.545 µM -0.635826948864368 0.275248278626848 no 2455 0.262444610251852 3517 3436683
SGTC_3325 9138760 55.175 µM -0.636601293200015 0.275008505176226 no 2456 0.262192291317254 3540 43844959
SGTC_3077 9117319 49.47 µM -0.637533946581102 0.274719848465152 no 2457 0.261888552708825 3578 17154678
SGTC_2995 9067767 71.4286 µM -0.637834866570994 0.274626745458366 no 2458 0.261790590167085 3538 11673567
SGTC_2126 5251174 33.877 µM -0.63838148322702 0.274457665061327 no 2459 0.261612690774009 3610 790722
SGTC_372 0155-0182 15.9 µM -0.638909670655855 0.274294334042684 no 2460 0.261440848237341 3566 771486
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.642133943323156 0.273298336433313 no 2461 0.260393109232162 3605 676296 Flavone; oxidizing agent.
SGTC_1039 k821-0043 94 µM -0.642161287793703 0.273289897224955 no 2462 0.26038423280596 3572 15992768
SGTC_687 k029-0044 34.9 µM -0.643012187824466 0.273027352065742 no 2463 0.260108095772571 3598 5829338
SGTC_3300 9124615 50.48 µM -0.643259565627278 0.272951047123668 no 2464 0.260027844202914 3618 24824903
SGTC_1105 epirubicin 18.1 µM -0.645029393979213 0.27240544320059 no 2465 0.259454068717412 3535 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1866 st057638 64 µM -0.646543567612814 0.271939083065025 no 2466 0.258963695664224 3567 688802
SGTC_829 1635-0120 117 µM -0.646625414245805 0.271913885909078 no 2467 0.258937202867314 3589 285054
SGTC_1948 st076329 66.6 µM -0.64680052727289 0.271859979831178 no 2468 0.258880525539575 3508 24208413
SGTC_2966 9084041 48.03 µM -0.64681488864082 0.271855559122347 no 2469 0.2588758776039 3500 17741380
SGTC_60 0986-0278 202 µM -0.64899509833979 0.271184863249271 no 2470 0.258170772232283 3434 3110598
SGTC_1223 0764-0573 147 µM -0.650869975532833 0.270608757058314 no 2471 0.257565212219937 3619 1609797
SGTC_2462 5162487 171.77 µM -0.650978450335179 0.270575443988864 no 2472 0.25753019891219 3568 2259986
SGTC_2349 9023730 187.07 µM -0.651062055901282 0.270549769764758 no 2473 0.257503214540296 3587 4126287
SGTC_651 3253-0966 34.4 µM -0.651243656616002 0.270494006648731 no 2474 0.257444606502745 3597 781462
SGTC_585 0kpi-0023 191 µM -0.653130383350834 0.26991500000183 no 2475 0.25683611305328 3560 64601
SGTC_112 phenothiazine 287.218 µM -0.654278596209726 0.269562935510571 no 2476 0.256466166467595 3608 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_278 4092-0821 23.9 µM -0.654428032956992 0.26951713221331 no 2477 0.256418039362004 3593 877900
SGTC_774 k060-0086 136 µM -0.655032306308457 0.26933195843663 no 2478 0.256223477080576 3630 5911235
SGTC_2351 9026858 72.31 µM -0.659441534136497 0.267982726873022 no 2479 0.254806139171184 3559 1409300
SGTC_1219 1469-0211 33.1 µM -0.660411432215137 0.267686393640608 no 2480 0.254494918891743 3594 6822282
SGTC_1680 diphenhydramine 100 µM -0.660813166202572 0.26756370012865 no 2481 0.254366069102057 3602 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_998 3996-0085 177 µM -0.661321032155104 0.267408633458137 no 2482 0.254203228121417 3631 715391
SGTC_883 0850-0245 24.6 µM -0.661789009389484 0.267265786147259 no 2483 0.254053225377132 3644 6823229 YPR165W RHO1
SGTC_3098 9119039 49.47 µM -0.662996302624208 0.266897444851769 no 2484 0.253666461042143 3638 17161528
SGTC_1478 0453-0656 35.7 µM -0.663003674665413 0.266895196453649 no 2485 0.253664100310466 3631 5258496
SGTC_47 0149-0135 24.25 µM -0.664427347332266 0.266461170100917 no 2486 0.253208417272093 3561 5239155
SGTC_1064 honokiol 6.76 µM -0.665422107068194 0.266158115839742 no 2487 0.252890274505385 3619 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2359 9039622 200 µM -0.665666698345069 0.266083627672296 no 2488 0.252812081879167 3592 6463596
SGTC_1583 clindamycin 39.6 µM -0.665939668578539 0.26600050940566 no 2489 0.252724831903705 3550 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2468 5987765 72.9 µM -0.666155406296896 0.265934827501057 no 2490 0.252655886481597 3633 26772094
SGTC_3148 9097893 49.47 µM -0.666617347324721 0.26579421600421 no 2491 0.252508292771346 3555 17174100
SGTC_1091 telmisartan 47.6 µM -0.66758744287432 0.265499048677798 no 2492 0.252198487726006 3688 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1619 st003326 88.7 µM -0.669597894725036 0.264887865937152 no 2493 0.251557078242734 3600 2849032
SGTC_1993 st073995 70.8 µM -0.672749067273615 0.263931341995392 no 2494 0.250553472818922 3631 3098394
SGTC_1341 1486-1360 280 µM -0.673041370948943 0.26384270387294 no 2495 0.250460485723674 3629 3976547
SGTC_1834 st055981 52.8 µM -0.673884445066565 0.263587135249067 no 2496 0.250192391049016 3666 471719 YDL150W RPC53
SGTC_504 lovastatin 124 µM -0.674338826299799 0.263449446990714 no 2497 0.250047962519484 3598 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2549 cedrol 20.94 µM -0.675742934622303 0.263024201105028 no 2498 0.249601935709929 3594 6708665 A sedative which affects the nervous system.
SGTC_556 4058-0063 51.5 µM -0.676777962387847 0.262710959108248 no 2499 0.249273421242637 3698 6615692
SGTC_1986 st071812 45 µM -0.677014903851259 0.262639277724565 no 2500 0.249198249139309 3616 11838594
SGTC_2537 larixol 68.93 µM -0.677864601957009 0.262382302732545 no 2501 0.248928772889984 3650 6708759
SGTC_10 0279-0212 42.575 µM -0.677977087080881 0.262348293404483 no 2502 0.248893110589875 3662 39851 YBR002C RER2
SGTC_173 1273-0061 2.693 µM -0.678245681565861 0.262267094305479 no 2503 0.248807966355637 3601 2847414 YPL266W DIM1
SGTC_569 4130-2812 160 µM -0.679244970572452 0.26196511121519 no 2504 0.248491328766408 3557 743552
SGTC_245 methotrexate 289.6 µM -0.679636544591539 0.261846826983614 no 2505 0.248367312076232 3634 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1210 3013-0140 750 nM -0.679690802302392 0.261830439314569 no 2506 0.248350130541757 3665 905973
SGTC_2621 lithochol-11-enic acid 100 µM -0.680877807114298 0.261472055288102 no 2507 0.247974405908742 3639 6708711
SGTC_1285 0929-0069 65.5 µM -0.680950723076309 0.261450048497928 no 2508 0.247951335589245 3651 1206237
SGTC_2432 5630864 12.22 µM -0.681549834150106 0.261269266608384 no 2509 0.247761822612565 3623 5714970
SGTC_2136 5328288 199.296 µM -0.683319037441218 0.260735784252793 no 2510 0.247202633554418 3631 262395
SGTC_2174 5790901 200 µM -0.683328584610872 0.26073290693785 no 2511 0.247199617828739 3658 786020
SGTC_2326 6164455 177.58 µM -0.684543896612483 0.260366771078605 no 2512 0.246815890139781 3636 2888790
SGTC_1400 3771-8998 51.5 µM -0.685302304129526 0.260138420671876 no 2513 0.246576589064112 3604 670767
SGTC_1817 st052116 64.4 µM -0.686828814268387 0.259679113952584 no 2514 0.246095304890253 3661 4361398
SGTC_1959 st077091 55.8 µM -0.686939432186327 0.259645846756594 no 2515 0.246060448424539 3664 821356 YKL052C ASK1
SGTC_145 3737-0113 38.366 µM -0.687544173358019 0.259464015995106 no 2516 0.245869937152787 3687 6849351
SGTC_2790 5423970 71.43 µM -0.689005938086877 0.259024771156093 no 2517 0.245409765376282 3681 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2413 inermin 26.06 µM -0.689659610767882 0.258828473935715 no 2518 0.245204135392407 3722 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1701 st028638 40.4 µM -0.692015358088489 0.258121684604614 no 2519 0.244463842120795 3644 3490878
SGTC_58 0957-0393 9 µM -0.693527725142338 0.25766846071543 no 2520 0.243989216417398 3620 6997992
SGTC_1879 gemcitabine 100 µM -0.695713122335743 0.257014274806988 no 2521 0.24330425297357 3681 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3270 9137563 49.47 µM -0.69575947780583 0.257000407930547 no 2522 0.243289735162154 3649 17015724
SGTC_1151 3909-8316 15.3 µM -0.696642228989646 0.256736414109596 no 2523 0.243013360611922 3689 800431
SGTC_3335 9143315 29.6265 µM -0.697286131819395 0.256543938887487 no 2524 0.242811872626731 3662 4899691
SGTC_249 wiskostatin 11.211 µM -0.698354132448365 0.25622485829285 no 2525 0.242477876771821 3667 2775510 A n-wasp and actin depolymerizer.
SGTC_156 3474-0145 5.642 µM -0.698568553625202 0.2561608218227 no 2526 0.242410850843203 3610 2265471
SGTC_3268 9137683 49.47 µM -0.699086691235258 0.256006115482536 no 2527 0.242248927618454 3683 1953228
SGTC_268 camptothecin 39.6153 µM -0.699374724417669 0.255920135167816 no 2528 0.242158939705225 3679 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_783 0848-0141 92.7 µM -0.702875402038104 0.254876359313666 no 2529 0.241066700849626 3670 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1496 4469-0713 57.4 µM -0.703759280026939 0.254613171505603 no 2530 0.240791348144307 3661 746691
SGTC_2245 6637752 200 µM -0.704840130373498 0.254291525819648 no 2531 0.240454865768354 3672 681890
SGTC_2875 9039966 71.43 µM -0.704963403515675 0.254254855024102 no 2532 0.240416505556323 3726 6463691
SGTC_167 3672-0051 66.205 µM -0.705190276022813 0.254187373156384 no 2533 0.240345915943405 3639 3237971
SGTC_1043 0916-0009 19.3 µM -0.706454922033642 0.25381138394721 no 2534 0.239952638159535 3711 3101130
SGTC_537 1334-0398 209 µM -0.707112369276863 0.25361603511707 no 2535 0.239748324896467 3670 5846986
SGTC_435 c-PAF 6.7 µM -0.708016679154354 0.253347464495734 no 2536 0.239467449888658 3704 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3009 9080819 71.4286 µM -0.708060866015439 0.253334345289964 no 2537 0.23945373023334 3707 17027216
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.708346844024805 0.253249446234777 no 2538 0.239364946803428 3733 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2692 st077426 47.7 µM -0.708822943050582 0.253108138637632 no 2539 0.239217179161014 3670 25238571
SGTC_1189 1431-2119 7.28 µM -0.709190457645065 0.252999087591796 no 2540 0.239103147145801 3707 3107275
SGTC_2714 st079313 56.9 µM -0.710817399235513 0.252516629241918 no 2541 0.238598698607459 3687 2939799
SGTC_3184 9108758 49.47 µM -0.711041255088959 0.252450284285868 no 2542 0.238529335610175 3697 902885
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.711571465217514 0.252293180676233 no 2543 0.238365091057996 3746 65057 A dermal irritant. YDR527W RBA50
SGTC_554 4483-2211 187 µM -0.712496689241073 0.252019156204396 no 2544 0.238078630436059 3708 747107
SGTC_709 3807-1509 243 µM -0.713624062012347 0.251685473521852 no 2545 0.23772983726457 3739 1886677 YPL242C IQG1
SGTC_1938 st074717 56.4 µM -0.714036193277443 0.251563548120484 no 2546 0.237602399689047 3596 17250979
SGTC_1317 1273-0028 910 nM -0.714518663289163 0.251420853278886 no 2547 0.237453259891188 3686 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_201 4262-0159 12.803 µM -0.717128464327148 0.25064972333517 no 2548 0.236647416912567 3690 1341029
SGTC_2265 7929201 200 µM -0.717989888537355 0.250395469617275 no 2549 0.236381760725258 3702 1265108
SGTC_103 0844-0104 51.839 µM -0.718149416675578 0.25034839908632 no 2550 0.236332581574179 3726 5375804
SGTC_1289 0976-0073 69.1 µM -0.71856733186776 0.250225110857982 no 2551 0.236203773872342 3741 3391136
SGTC_1436 4092-1007 8.32 µM -0.719142707529501 0.250055423261528 no 2552 0.236026497783248 3687 2881121
SGTC_2971 9092186 9.93 µM -0.7195208306622 0.249943941882048 no 2553 0.235910036107266 3703 25236400
SGTC_2623 humulene 100 µM -0.721278583736016 0.249426053132139 no 2554 0.235369065392558 3650 6187145 An anti-inflammatory.
SGTC_2427 5545055 42.75 µM -0.721524150361856 0.249353746993927 no 2555 0.235293543710231 3708 5372858
SGTC_2040 5100729 123 µM -0.721546138783088 0.249347273132358 no 2556 0.235286782032857 3728 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_663 1486-0733 13.9 µM -0.723633561510015 0.248733098304005 no 2557 0.234645365685922 3725 722445 YPR165W RHO1
SGTC_2595 hexamethylquercetagetin 100 µM -0.724213749129049 0.248562534982102 no 2558 0.23446725943935 3671 386331
SGTC_1131 3454-3128 32.3 µM -0.724215850224667 0.248561917416117 no 2559 0.234466614580059 3792 710982
SGTC_2741 miltefosine 3.04 µM -0.725054865471525 0.24831537462959 no 2560 0.234209186049359 3658 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1085 doxorubicin 7.67 µM -0.725518061656978 0.248179321322813 no 2561 0.234067134228527 3721 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2053 5265679 138 µM -0.725935217056912 0.248056825479114 no 2562 0.23393924292654 3693 764595
SGTC_2129 girgensonine 121.053 µM -0.726844452660306 0.247789944265157 no 2563 0.233660624108332 3773 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2779 methotrexate 400 µM -0.727793805769294 0.24751145133403 no 2564 0.233369908439638 3767 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3103 9120822 49.47 µM -0.730313591814695 0.246773083331849 no 2565 0.2325992610177 3772 17141819
SGTC_2676 harmalol 100 µM -0.730644712794305 0.246676143337546 no 2566 0.232498096773667 3713 5459187 A monoamine oxidase inhibitor
SGTC_850 0388-0143 75.9 µM -0.730896720575343 0.246602378435197 no 2567 0.23242111963252 3694 67273
SGTC_2320 7373003 200 µM -0.734229980585701 0.245627816454161 no 2568 0.231404292089799 3761 5415828
SGTC_2844 9010103 25.97 µM -0.734977924382799 0.245409420861342 no 2569 0.231176469363535 3736 2480525
SGTC_2490 carminic acid 95.39 µM -0.736458956653098 0.244977275426397 no 2570 0.230725718302247 3661 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_441 propafenone 146 µM -0.738810824977789 0.244291873822604 no 2571 0.230010938827136 3707 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1627 st003713 25.6 µM -0.741831867060406 0.243412974721333 no 2572 0.229094605164771 3795 16195070 YER133W GLC7
SGTC_3005 9076496 71.4286 µM -0.741900658490763 0.243392981433326 no 2573 0.229073763421384 3758 21368410
SGTC_203 k066-0004 30.888 µM -0.742388113159877 0.243251334827855 no 2574 0.22892610972874 3808 6795412
SGTC_1386 3228-0095 33.8 µM -0.742634548062086 0.243179741710405 no 2575 0.228851483070098 3727 870181
SGTC_908 3448-7491 47.7 µM -0.744527344772597 0.242630235220983 no 2576 0.228278752244238 3779 1203031
SGTC_2704 st078022 71.1 µM -0.74570129128867 0.242289759528492 no 2577 0.227923939485509 3762 54697681
SGTC_3039 9090270 49.47 µM -0.746598458293202 0.242029731909531 no 2578 0.227652989659455 3724 17173750
SGTC_2388 9080168 200 µM -0.746820267255042 0.241965467938309 no 2579 0.227586029988721 3722 15943073
SGTC_1477 0139-0234 16 µM -0.747021851445432 0.241907071651822 no 2580 0.227525185390464 3756 620880
SGTC_2835 9006588 71.43 µM -0.747437500849205 0.241786687630144 no 2581 0.227399757941603 3787 2345538
SGTC_653 0203-0016 55.2 µM -0.750213070740242 0.240983636806084 no 2582 0.226563193928264 3785 295302
SGTC_288 1315-0019 35.1 µM -0.750579271113664 0.240877793109277 no 2583 0.22645295005851 3820 6811474
SGTC_1696 st025591 34.7925 µM -0.750880729356382 0.240790680954368 no 2584 0.226362219410382 3746 2787147
SGTC_1575 cyproterone acetate 48 µM -0.751161301396944 0.24070961967334 no 2585 0.226277793385675 3757 9880 An androgen receptor antagonist and liver toxin.
SGTC_1524 corynanthine 62.1 µM -0.751687294597014 0.240557692733396 no 2586 0.226119566417607 3863 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_529 4076-0302 30.3 µM -0.751979730293253 0.240473248715035 no 2587 0.226031624246617 3729 5816522
SGTC_32 0928-0142 34.1 µM -0.755310847762566 0.239512492176055 no 2588 0.2250312456947 3718 2244242
SGTC_3170 9103054 49.47 µM -0.75650400166513 0.239168874751183 no 2589 0.224673537039622 3754 16432970
SGTC_1936 st074407 74.3 µM -0.757195515035865 0.238969848597772 no 2590 0.224466368395663 3798 809813
SGTC_1168 k815-0004 80.5 µM -0.757290511025625 0.23894251464609 no 2591 0.224437917272056 3747 642433
SGTC_2052 5265182 7.135 µM -0.758952405689082 0.238464601155694 no 2592 0.223940514084857 3770 1239884
SGTC_1957 st077035 62.4 µM -0.759203895815173 0.238392325388897 no 2593 0.223865297979508 3811 705593
SGTC_2928 9011484 9.79 µM -0.759832746737029 0.238211652384999 no 2594 0.223677282999589 3786 2994751
SGTC_76 0433-0009 400.328 µM -0.761746510326932 0.237662277354197 no 2595 0.223105655233354 3852 2841569
SGTC_1626 st003712 1.76 µM -0.761945107530027 0.23760530683665 no 2596 0.223046383316506 3730 24207035
SGTC_1216 1165-0504 9.65 µM -0.762247958459025 0.237518444039598 no 2597 0.222956013836185 3751 6304004
SGTC_1025 k007-0731 70 µM -0.763128944603344 0.237265861354297 no 2598 0.222693249777356 3755 6256118
SGTC_3295 9122362 53.5725 µM -0.763674848803413 0.237109422227677 no 2599 0.222530516302936 3806 4730473
SGTC_2570 licareol 100 µM -0.767028227273455 0.236149692950511 no 2600 0.221532366468785 3809 443158
SGTC_82 0054-0107 293.755 µM -0.767114087275807 0.236125148140859 no 2601 0.221506843456782 3767 3104697
SGTC_1330 1469-0054 61.8 µM -0.767668587051227 0.2359666670708 no 2602 0.22134205161193 3814 7102664
SGTC_1882 5615643 20 µM -0.768080155456105 0.235849074996604 no 2603 0.221219782900157 3708 2253075
SGTC_316 k060-0003 58.6 µM -0.768198111608409 0.235815378880276 no 2604 0.221184747619691 3758 6152314
SGTC_1591 genipin 88.4 µM -0.768201379274987 0.23581444545532 no 2605 0.2211837771041 3806 442424 A DNA cross-linking agent.
SGTC_1003 4049-0218 100 µM -0.768720145634522 0.235666283139734 no 2606 0.221029731437012 3777 295161
SGTC_1422 4031-0024 15.5 µM -0.769063263432578 0.235568315164956 no 2607 0.22092787767682 3726 782427
SGTC_39 0986-0283 58.349 µM -0.769114570949689 0.235553667627228 no 2608 0.22091264946331 3838 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2246 7293507 91.5585 µM -0.769248360574805 0.235515475030434 no 2609 0.220872943157671 3832 887656
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.769313221906202 0.235496960454746 no 2610 0.220853694975439 3849 5393153
SGTC_2253 7938677 135.83 µM -0.769353835983535 0.235485367632475 no 2611 0.220841642872455 3823 2301972
SGTC_930 2810-3379 265 µM -0.771874171176383 0.234766583300953 no 2612 0.220094478224772 3801 1015764
SGTC_280 3448-3607 3.04 µM -0.771950435922144 0.234744851980154 no 2613 0.220071891824929 3765 626179
SGTC_2328 6201408 200 µM -0.771987146437673 0.234734391868587 no 2614 0.220061020193229 3800 2890418
SGTC_1956 st077085 54 µM -0.772365325451616 0.234626650425222 no 2615 0.219949042345893 3830 24208685
SGTC_2575 plumbagin 510 nM -0.773090369370893 0.23442016528246 no 2616 0.219734450136585 3734 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_381 3461-2219 42.7 µM -0.77311910626651 0.234411983378653 no 2617 0.219725947316717 3765 2883159
SGTC_2065 5221596 34.26 µM -0.773953766914087 0.234174409649806 no 2618 0.219479066084953 3781 788581
SGTC_1744 st037937 38.9 µM -0.774042209935427 0.234149243474278 no 2619 0.219452915186656 3827 1016152
SGTC_3275 9138069 49.47 µM -0.774314510748517 0.234071770563003 no 2620 0.219372412320804 3895 17617007
SGTC_4 0960-0234 25.671 µM -0.776707806632346 0.233391459691142 no 2621 0.218665590000822 3778 6821112
SGTC_1917 st066507 28.5 µM -0.779983070213426 0.232462223903068 no 2622 0.217700420139973 3773 3156428
SGTC_3000 9075062 71.4286 µM -0.781496344955741 0.232033583678016 no 2623 0.217255312798831 3788 17057871
SGTC_1378 2093-0007 380 nM -0.781552757917073 0.232017613026878 no 2624 0.21723872993111 3872 3618014
SGTC_953 1188-0045 9.7 µM -0.782331169882895 0.231797305140049 no 2625 0.217009986555966 3824 6144426
SGTC_2603 homopterocarpin 100 µM -0.782573096039639 0.231728858405855 no 2626 0.216938922736585 3856 101795 A weak amylase inhibitor.
SGTC_1767 st044992 70.3 µM -0.782607247730983 0.231719196977312 no 2627 0.216928892041602 3840 9600693
SGTC_2682 pyrogallin 40.03 µM -0.786502653359919 0.230618670368311 no 2628 0.215786532606676 3838 822798 An ATP competetive kinase inhibitor.
SGTC_1650 st011916 45.8 µM -0.787060774752795 0.230461229948773 no 2629 0.215623145018834 3760 242528
SGTC_1500 4488-1866 171 µM -0.787092168234549 0.230452375949137 no 2630 0.215613956846283 3917 2900003
SGTC_632 0781-2353 4.65 µM -0.78754328342301 0.230325167553331 no 2631 0.21548195055581 3871 6811515 YHR007C ERG11
SGTC_1622 st003707 19.4 µM -0.789458189509103 0.229785627188227 no 2632 0.214922128731344 3868 10140899
SGTC_1049 3226-0134 66 µM -0.78971851549317 0.229712332909373 no 2633 0.214846087842016 3845 5702385
SGTC_985 1493-0307 8.71 µM -0.789801559962397 0.229688954654061 no 2634 0.214821833946453 3812 3278274
SGTC_50 0929-0078 56.389 µM -0.789999601666625 0.229633208342417 no 2635 0.214764000478506 3709 1377751
SGTC_2731 amoxapine 43.43 µM -0.7905634650673 0.229474529224485 no 2636 0.214599386857726 3865 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2963 9082507 9 µM -0.791565477424869 0.229192700483018 no 2637 0.21430704157851 3853 16459611
SGTC_229 benomyl 22.8748 µM -0.792638516402291 0.228891109950402 no 2638 0.213994230717558 3842 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2755 lomerizine 42.69 µM -0.793015109366972 0.228785316784467 no 2639 0.21388450988853 3828 3949 A calcium channel blocker.
SGTC_1340 1486-1359 257 µM -0.795137379195768 0.228189638458698 no 2640 0.21326679665555 3763 4309068
SGTC_298 1391-0729 10 µM -0.795235768154126 0.228162043828502 no 2641 0.213238184569746 3788 3237558
SGTC_813 k007-0158 173 µM -0.79602815668882 0.227939875226512 no 2642 0.213007834960965 3841 6523916
SGTC_1597 7-benzyloxygramine 47.5 µM -0.79610390603536 0.227918643123667 no 2643 0.212985822015261 3802 260807
SGTC_557 1315-0110 16.2 µM -0.796502465788311 0.227806947465264 no 2644 0.212870021442172 3826 6833801
SGTC_2479 5617353 43.85 µM -0.796631211741866 0.227770873225522 no 2645 0.212832622470352 3847 2731746
SGTC_2370 9071495 200 µM -0.797287206409463 0.227587115371033 no 2646 0.212642124387636 3839 21791103
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.797570313616333 0.227507836902757 no 2647 0.212559942017756 3878 688664
SGTC_197 4544-0043 41.561 µM -0.797629013423631 0.227491401151516 no 2648 0.212542904543277 3821 896523
SGTC_1349 flufenamic acid 69 µM -0.798443332532345 0.227263463501765 no 2649 0.21230663272734 3785 3371 A non-steroidal anti-inflammatory.
SGTC_1121 fusaric acid 630.51 nM -0.798529300435677 0.227239407571292 no 2650 0.212281698404606 3838 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1809 st050081 57.6 µM -0.798693988071384 0.227193327934489 no 2651 0.212233936815084 3883 5036894
SGTC_602 3130-1533 38.1 µM -0.799809608779939 0.226881315727801 no 2652 0.211910557511839 3872 720941
SGTC_2314 7727897 200 µM -0.801534214978596 0.226399460923474 no 2653 0.211411222278819 3854 900724
SGTC_2696 st077691 74.316 µM -0.802938314465888 0.226007582851932 no 2654 0.211005194585561 3846 757133
SGTC_2974 9094440 9.66 µM -0.80408728403957 0.225687195902362 no 2655 0.210673283926057 3899 25236134
SGTC_1030 k029-0042 36.7 µM -0.804191472689677 0.225658155901166 no 2656 0.210643201396315 3840 6080581
SGTC_2143 5623677 140.463 µM -0.805196489309035 0.225378141035422 no 2657 0.210353151023441 3790 5375313
SGTC_3221 9128209 49.47 µM -0.805475440998855 0.225300455205537 no 2658 0.21027268644491 3880 16460723
SGTC_482 fipronil 114 µM -0.805565437756427 0.225275395059157 no 2659 0.210246730426131 3871 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3179 9107801 49.47 µM -0.806220099401123 0.225093148044417 no 2660 0.210057975702723 3839 4818259
SGTC_1441 4106-0040 13 µM -0.806231853572338 0.225089876640413 no 2661 0.210054587602091 3820 2904180
SGTC_2331 7980721 200 µM -0.808565230147021 0.224440988336325 no 2662 0.209382635637752 3819 2981221
SGTC_1663 st014140 55.4 µM -0.809198036390747 0.224265194518426 no 2663 0.209200622113038 3904 4207120
SGTC_456 gingerol 170 µM -0.809218293142077 0.224259568476708 no 2664 0.209194797219766 3851 442793 A herb.
SGTC_2451 5856223 45.7 µM -0.809227382377279 0.224257044089258 no 2665 0.209192183612308 3828 2179896
SGTC_2532 xanthone 78.9 µM -0.811640177166344 0.223587500356922 no 2666 0.208499065136073 3811 7020 An insecticide.
SGTC_2362 9071156 126 µM -0.81228194513033 0.223409603159449 no 2667 0.20831493405703 3862 653133
SGTC_152 4469-0003 551.229 µM -0.813502092219363 0.223071602269105 no 2668 0.207965123611357 3783 697280
SGTC_2852 9023854 51.95 µM -0.813827088930983 0.22298162194898 no 2669 0.207872007102125 3927 19798528
SGTC_2286 7945697 125 µM -0.8172218092468 0.22204297818923 no 2670 0.206900840629762 3887 1245733
SGTC_3048 9093155 49.47 µM -0.818108226499961 0.221798254796067 no 2671 0.206647695946638 3780 25236002
SGTC_2837 9008476 45.46 µM -0.822068237141936 0.220706852656602 no 2672 0.205519030841552 3839 2992805
SGTC_227 fluconazole 33.516 µM -0.822543122805701 0.220576178255356 no 2673 0.205383927197812 3858 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2456 5770359 74.46 µM -0.82354777751373 0.220299873316053 no 2674 0.205098279640423 3875 3118787
SGTC_3015 9080845 49.47 µM -0.827096078211127 0.21932559227896 no 2675 0.20409130345007 3950 5296973
SGTC_593 1203-0218 61.7 µM -0.827475064741505 0.21922167793665 no 2676 0.20398392479488 3898 3666956
SGTC_2357 9067248 200 µM -0.828154257447885 0.219035520867687 no 2677 0.203791572646053 3894 9150235
SGTC_590 k048-0076 22.4 µM -0.83210193663632 0.217955319494107 no 2678 0.20267570440303 3877 6832814
SGTC_363 0455-0021 3.06 µM -0.834101251728353 0.217409421803984 no 2679 0.202111964923174 3876 4597466
SGTC_1563 conessine 56.1 µM -0.835098669030928 0.217137380050912 no 2680 0.201831078008929 3957 441082 An anti-amoebic, histamine inhibitor.
SGTC_1871 st057448 67.3 µM -0.837947937145994 0.216361337280856 no 2681 0.201029972078953 3919 691747
SGTC_618 k072-0232 33.2 µM -0.838837961222301 0.216119254748267 no 2682 0.200780122612389 3939 5872756 YGL099W LSG1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.842293456531764 0.215180863710771 no 2683 0.199811856410476 3931 61125 An anti-inflammatory.
SGTC_351 caspofungin 25 nM -0.842520540383068 0.215119278651039 no 2684 0.199748323628204 3894 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3118 9124250 49.47 µM -0.843491617203284 0.214856038426198 no 2685 0.199476776037873 3843 1504786
SGTC_531 3788-1495 174 µM -0.844942189334591 0.214463164992401 no 2686 0.199071558650264 3869 2896655
SGTC_1746 st038117 42 µM -0.844959716010167 0.214458420617202 no 2687 0.199066665607023 3969 2898218
SGTC_2279 7948423 32.93 µM -0.845053221977979 0.214433110094549 no 2688 0.19904056212382 3826 1247112
SGTC_2438 5259590 200 µM -0.846175290786808 0.214129520094801 no 2689 0.198727482005239 3924 1201127
SGTC_2772 vinpocetine 57.06 µM -0.847333332244164 0.213816459664587 no 2690 0.198404676342997 3887 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1305 1181-0477 144 µM -0.847603981378786 0.213743331873196 no 2691 0.198329278159767 3946 6252086
SGTC_2083 5306046 65.942 µM -0.848470546258886 0.213509289192398 no 2692 0.198087984465488 3922 539837
SGTC_1405 3909-7894 12 µM -0.848528118377777 0.213493745351314 no 2693 0.198071959877182 3918 7104060
SGTC_2897 9048598 12.99 µM -0.850068529439354 0.213078096194925 no 2694 0.197643493529137 3884 6467404
SGTC_474 dl-dihydrosphingosine 5 µM -0.850321263187018 0.213009946149562 no 2695 0.19757324900626 3893 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_256 clotrimazole 625 nM -0.851684150150305 0.212642660841572 no 2696 0.197194709994086 3841 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_956 1185-0240 191 µM -0.851789226397787 0.212614359138028 no 2697 0.19716554351636 3902 1416193
SGTC_102 gallobenzophenone 83.616 µM -0.852147598613981 0.212517850119701 no 2698 0.197066088192819 3902 70837
SGTC_983 1491-0821 12.2 µM -0.852582708825066 0.212400710093923 no 2699 0.196945377387669 3919 46495113
SGTC_1807 st050092 58.9 µM -0.852588121341716 0.212399253178094 no 2700 0.196943876097739 3931 5008496
SGTC_1600 coumarin 106 71.1 µM -0.853082288727656 0.212266260125891 no 2701 0.196806836239677 3987 100336 A hepatotoxic, DNA x-linker.
SGTC_500 h-89 112 µM -0.855114214722958 0.211719928752664 no 2702 0.196243960497674 3948 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_873 0591-4978 488 µM -0.855409679793385 0.211640554567363 no 2703 0.196162193346221 3981 3305145
SGTC_1558 st069300 45.6 µM -0.856567798670664 0.211329603742014 no 2704 0.195841894196722 3831 24208000
SGTC_57 miconazole 162.5 nM -0.858205789049093 0.210890266348101 no 2705 0.195389419985174 3862 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_463 ikarugamyin 104 µM -0.859307488836008 0.210595072868388 no 2706 0.195085446797832 3964 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1034 k072-0165 12.7 µM -0.860453248291691 0.210288331226911 no 2707 0.194769622100426 3957 5835461
SGTC_2001 4023502 57.655 µM -0.860932328107192 0.210160150254219 no 2708 0.194637657641014 3945 108941 YCR052W RSC6
SGTC_3035 9091303 49.47 µM -0.8614771625678 0.210014431980599 no 2709 0.194487646935233 3960 25237002
SGTC_588 3970-1144 52.9 µM -0.862119177814852 0.209842798514371 no 2710 0.194310969535009 3833 1888707
SGTC_765 1319-0117 244 µM -0.86229487061722 0.209795843964541 no 2711 0.19426263733434 3873 3487746 YGL099W LSG1
SGTC_3182 9108849 49.47 µM -0.863102641265548 0.209580043772532 no 2712 0.194040517938757 3965 17133045
SGTC_1615 st002656 86.5 µM -0.865762848633041 0.208870278956925 no 2713 0.193310113239234 3913 1584458
SGTC_767 0929-0023 86 µM -0.866486255622508 0.208677513320462 no 2714 0.193111780212125 3946 1204563
SGTC_2931 9014674 55.67 µM -0.86665347483097 0.208632969487667 no 2715 0.193065952206625 3928 2996810
SGTC_339 3091-4833 71.4 µM -0.866841903430968 0.208582782616659 no 2716 0.19301431952466 3834 3240077
SGTC_2725 haloperidol 53.21 µM -0.867170847103001 0.208495187426164 no 2717 0.192924203503441 3875 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.867198695609144 0.2084877725775 no 2718 0.19291657542418 3847 107982 A Capsaicinoid.
SGTC_2305 7443522 69.23 µM -0.867397797822384 0.208434764828593 no 2719 0.192862044024906 3843 5415886
SGTC_1602 st001878 87.6 µM -0.870245248990022 0.207677546992196 no 2720 0.192083196332319 3942 595405 YLR310C CDC25
SGTC_3070 9117005 49.47 µM -0.87164490959927 0.207305934179386 no 2721 0.191701061371891 3965 8779016
SGTC_94 0334-0113 514.748 µM -0.872097547545736 0.207185842048185 no 2722 0.191577581974934 3950 6795178
SGTC_558 k064-0027 21.3 µM -0.872819572892258 0.206994362296315 no 2723 0.191380714706725 3961 5088526
SGTC_2487 5918373 44.05 µM -0.873000651079601 0.206946357133549 no 2724 0.191331361420841 3961 2876279
SGTC_3131 9127911 49.47 µM -0.873027419869465 0.20693926108898 no 2725 0.191324066186059 3975 45595681
SGTC_2824 7998404 51.95 µM -0.874030548806494 0.20667344897737 no 2726 0.191050808748738 3911 837851
SGTC_2223 6903751 107.57 µM -0.874716783957525 0.206491724853857 no 2727 0.190864012739323 3888 5598863
SGTC_1283 0922-0125 16.4 µM -0.876141515871408 0.206114739454499 no 2728 0.190476552865049 3942 3360884
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.876379196596059 0.206051888653533 no 2729 0.190411961958183 3984 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3030 9087619 49.47 µM -0.88050190088172 0.20496351594442 no 2730 0.189293737933741 3969 25236973
SGTC_834 0312-0008 75.7 µM -0.880886674815508 0.204862112273565 no 2731 0.189189580220082 3937 6385573 YIL048W NEO1
SGTC_1383 3049-0032 20.7 µM -0.881176948994328 0.204785632899125 no 2732 0.189111026803471 4020 712864
SGTC_1758 st042942 75.2445 µM -0.88175009348262 0.20463467474305 no 2733 0.188955982587573 3863 669317
SGTC_659 k018-0002 107 µM -0.88218545885231 0.204520049916976 no 2734 0.188838262049421 3949 6797879 YHR007C ERG11
SGTC_3018 9082602 49.47 µM -0.882235608987907 0.204506848632932 no 2735 0.18882470461623 3933 17332089
SGTC_2565 isoliquiritigenin 100 µM -0.882420340286617 0.204458225215826 no 2736 0.188774770100136 4036 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3345 9148410 3.559 µM -0.886346165631978 0.2034265302868 no 2737 0.187715509554712 3921 4903596
SGTC_1828 st055811 49 µM -0.887309425952047 0.203173863736978 no 2738 0.187456166068128 3984 5877589
SGTC_658 3253-0951 102 µM -0.890192175770755 0.202418828408088 no 2739 0.186681352597918 3959 1184878
SGTC_536 3852-0578 10.6 µM -0.890944925277891 0.202221948646155 no 2740 0.186479358636511 4024 2869208
SGTC_617 3770-0098 35 µM -0.893928655271337 0.201442689171701 no 2741 0.185680032413608 3892 5962639
SGTC_881 0833-0569 170 µM -0.894465395261896 0.201302700242514 no 2742 0.185536468390073 3966 5418700
SGTC_2895 9054447 58.44 µM -0.894642144477737 0.201256614463195 no 2743 0.185489207641496 3997 2697450
SGTC_508 roscovitine 141 µM -0.894723099697786 0.201235508224964 no 2744 0.18546756362304 4023 160355 A CDKinase inhibitor.
SGTC_2400 5203494 178.7 µM -0.894949505261633 0.201176487950001 no 2745 0.185407040627549 3886 6777674
SGTC_350 k064-0020 19.8 µM -0.897484453539613 0.200516376855142 no 2746 0.184730232721544 3956 2790705
SGTC_2984 9022109 38.96 µM -0.898325556963127 0.200297637745166 no 2747 0.184506005618506 3998 6459207
SGTC_1157 4092-0394 27.6 µM -0.902069606430443 0.199325693242284 no 2748 0.183509946548645 4070 3659885
SGTC_811 0416-0114 265 µM -0.905391129631165 0.198465817144305 no 2749 0.182629106682574 4047 6612453
SGTC_512 prima-1 270 µM -0.906348542404883 0.198218378197402 no 2750 0.182375699908819 3992 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1456 k015-0012 13 µM -0.90650961708008 0.198176767493313 no 2751 0.182333088471162 3961 2989616
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.908564015680313 0.197646513765668 no 2752 0.181790154163972 3982 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2426 5582046 32.21 µM -0.909830471569061 0.197320060889565 no 2753 0.181455960959953 3999 2251934
SGTC_1221 2958-7315 257 µM -0.910010935156465 0.197273569560752 no 2754 0.181408371436146 3999 4562705
SGTC_258 haloperidol 50.781 µM -0.910162820714921 0.197234445687024 no 2755 0.181368324196985 4011 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2317 5986382 200 µM -0.910261958080631 0.197208911638649 no 2756 0.181342187911674 4009 877883
SGTC_248 streptozotocin 5.23457 mM -0.911630816844172 0.196856549711733 no 2757 0.180981547113001 3988 5300 DNA alkylating agent.
SGTC_861 0443-0273 110 µM -0.912391253664159 0.196660968262551 no 2758 0.180781396043316 4001 6149169
SGTC_1791 st048313 56.1 µM -0.912477701701083 0.196638741610744 no 2759 0.180758651241381 3986 1204976
SGTC_3106 9121286 49.47 µM -0.913215756050401 0.19644904244485 no 2760 0.180564539427401 4017 15943471
SGTC_1170 0310-0127 64.8 µM -0.914951283231948 0.196003404050265 no 2761 0.180108602901163 4007 774975
SGTC_2938 9059746 27.26 µM -0.916379907793971 0.195637030865177 no 2762 0.17973383491636 4010 6471769
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.91826216713464 0.195154957540357 no 2763 0.179240814487159 4070 4213774
SGTC_462 ag-879 158 µM -0.918661655753337 0.195052735788521 no 2764 0.179136285899479 4017 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_391 gliotoxin 8.33 µM -0.918780862736204 0.195022239232136 no 2765 0.179105102108977 4088 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1196 1588-0294 184 µM -0.920684435388234 0.194535643718734 no 2766 0.178607602329493 4000 6144269
SGTC_2200 6600604 21.907 µM -0.920879284464534 0.194485877682452 no 2767 0.178556727558572 3963 2904777
SGTC_2089 5281248 129.67 µM -0.923062666512666 0.193928754242693 no 2768 0.177987274388835 3985 2737878
SGTC_2402 5553605 200 µM -0.923546942823572 0.193805315620845 no 2769 0.177861124446457 4085 6758546
SGTC_265 mycophenolic acid 32.932 µM -0.924043332580957 0.193678839086473 no 2770 0.17773187759456 4082 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1703 st026983 48.3 µM -0.924713839358487 0.193508078715063 no 2771 0.177557389347058 4005 1104023
SGTC_2572 astragaloside iv 100 µM -0.925086394778825 0.193413238388741 no 2772 0.177460484730635 4076 45006101 An anti-inflammatory agent.
SGTC_2460 5552655 174.22 µM -0.926459857888617 0.193063845024572 no 2773 0.177103524576861 4018 5401989
SGTC_1725 st036284 20.55 µM -0.92647417431453 0.193060205119572 no 2774 0.177099806158359 4099 707914
SGTC_202 3594-0513 34.79 µM -0.927421532882874 0.192819435399973 no 2775 0.176853857463312 3998 708429
SGTC_2319 6033012 152.6 µM -0.92948694768971 0.19229514969654 no 2776 0.17631839319366 3957 847246
SGTC_2677 mitomycin C 100 µM -0.930993261498074 0.19191333676549 no 2777 0.175928524933847 4028 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2301 7769476 200 µM -0.934215977243083 0.191098018713734 no 2778 0.175096247861905 4055 977820
SGTC_665 3914-0008 307 µM -0.935738879876638 0.190713478180822 no 2779 0.174703823630007 3954 1069549
SGTC_1590 st077108 57.8 µM -0.936586130805081 0.190499748826354 no 2780 0.174485744440551 4026 5489485
SGTC_2046 4110841 106 µM -0.938262052474481 0.190077410589022 no 2781 0.174054878054823 4022 44119630 YMR134W ERG29
SGTC_825 1988-2224 89.6 µM -0.93826879274899 0.190075713178449 no 2782 0.174053146549572 3996 1180859
SGTC_2429 5902844 64.44 µM -0.938302867514748 0.190067132236163 no 2783 0.174044393270156 4044 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3074 9116018 49.47 µM -0.939051876860437 0.189878571680952 no 2784 0.173852055062526 4072 17027303
SGTC_33 0986-0033 35.816 µM -0.940307956372853 0.189562616210461 no 2785 0.173529809801008 3934 2848082
SGTC_931 2812-0076 566 µM -0.941056566649954 0.189374463980537 no 2786 0.17333793589258 3992 3450959
SGTC_3230 9131665 49.47 µM -0.94108796765354 0.18936657431085 no 2787 0.173329890554409 3970 15943720
SGTC_40 0327-0103 19.753 µM -0.941097645570677 0.189364142723321 no 2788 0.173327410996361 3893 409036
SGTC_1480 1070-0044 41.2 µM -0.941978896142471 0.189142808085385 no 2789 0.173101722365819 4026 3124987
SGTC_3285 9112818 20.8695 µM -0.942955942858294 0.18889759963167 no 2790 0.172851719217659 3999 17017947 YPR165W RHO1
SGTC_3308 9128332 17.569 µM -0.944001978555363 0.188635294290369 no 2791 0.172584318604315 4042 17332805 YDL196W YDL196W
SGTC_890 0929-0006 47.2 µM -0.947831823159931 0.187676834779089 no 2792 0.171607538534595 4008 1378169
SGTC_215 1287-0124 461.5 µM -0.948090963371157 0.187612091025283 no 2793 0.171541574125776 4043 5560863
SGTC_2217 6934799 96.0675 µM -0.948971122824607 0.187392294481665 no 2794 0.171317649616731 3980 675606
SGTC_2303 7774051 200 µM -0.953613305668077 0.186235667679581 no 2795 0.170139709040855 4055 2953184
SGTC_2459 5811157 9.22 µM -0.954840621268812 0.185930615842279 no 2796 0.169829150774456 4006 2870684 YBR192W RIM2
SGTC_3055 9094636 49.47 µM -0.956620822746061 0.185488694079434 no 2797 0.169379337444125 4067 25236176
SGTC_2103 5378138 10 µM -0.958683731345475 0.184977408574097 no 2798 0.168859048292617 4094 244142
SGTC_863 0466-0191 129 µM -0.959143354432412 0.184863611814229 no 2799 0.168743266114374 4076 765160 YPR165W RHO1
SGTC_944 3370-0224 231 µM -0.95921038998954 0.184847018309583 no 2800 0.168726383666199 4084 4580514
SGTC_599 1935-0052 86.5 µM -0.959527140154494 0.184768624750193 no 2801 0.168646626978796 4038 9557311
SGTC_2015 5119600 184 µM -0.959740794172796 0.184715758474859 no 2802 0.168592843261925 4091 2828786
SGTC_2699 st077704 54.6 µM -0.960129063862568 0.184619709598237 no 2803 0.168495131288234 4048 645852
SGTC_418 lividomycin a 100 µM -0.960251783157363 0.184589358163678 no 2804 0.168464255317563 4064 72394 An antibiotic.
SGTC_1033 k072-0102 21.3 µM -0.960796104945143 0.184454771695733 no 2805 0.168327348718328 4029 5965931
SGTC_2533 agelasine 13.65 µM -0.962858720570103 0.18394533306539 no 2806 0.167809213812259 4111 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1826 st055655 41.6 µM -0.963533830430689 0.183778780406579 no 2807 0.167639847589844 4074 676168
SGTC_2355 9061122 103.12 µM -0.964020226156828 0.183658842620267 no 2808 0.167517892735505 4069 5302957
SGTC_600 1495-0418 41.6 µM -0.965642611962691 0.183259139725486 no 2809 0.167111522485392 4036 5377768
SGTC_629 3448-6466 76.7 µM -0.966028252679444 0.183164210301324 no 2810 0.167015021948149 4051 573744
SGTC_2569 tetrandrine 100 µM -0.966629613359515 0.1830162404117 no 2811 0.166864612602207 4065 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_677 0929-0063 136 µM -0.966929225757307 0.182942546087952 no 2812 0.166789707659773 4021 1539583
SGTC_65 0798-0905 34.986 µM -0.969442616005352 0.182325068160145 no 2813 0.166162199120821 4163 3602145
SGTC_2905 7799065 20.05 µM -0.969884721153302 0.182216588677643 no 2814 0.166051978346208 3979 1296806
SGTC_2546 rhodinyl acetate 100 µM -0.970372732535163 0.182096892017862 no 2815 0.165930367602079 4000 6708682
SGTC_1281 0884-0031 11.8 µM -0.972549886896599 0.181563490977832 no 2816 0.165388529700657 4070 1548255
SGTC_455 paf C-16 10 µM -0.973782691599025 0.181261888911461 no 2817 0.165082224421603 4026 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_570 0987-0065 62.6 µM -0.974893712895757 0.180990349759304 no 2818 0.164806492538249 3835 3104428
SGTC_308 4092-1169 104 µM -0.975056535088153 0.180950576628108 no 2819 0.164766108606303 3992 2268590 YDL196W YDL196W
SGTC_2943 9068529 45.32 µM -0.97621939212769 0.180666680848552 no 2820 0.164477877685513 4046 3270634
SGTC_2256 7954252 200 µM -0.97664021451953 0.180564011628241 no 2821 0.164373651358217 4086 2972920
SGTC_2567 aureobasidin a 60 nM -0.978506500127985 0.180109129808113 no 2822 0.163911939019 4226 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2871 9038510 12.99 µM -0.979553186968176 0.179854329233574 no 2823 0.16365336116833 3981 4945164
SGTC_1113 artemisinin 1.17947 µM -0.980105311660635 0.179720013828955 no 2824 0.163517068751636 4113 2240 An anti-malaria and mitochondrial poison.
SGTC_3164 9100705 49.47 µM -0.983619354985966 0.178866629944968 no 2825 0.162651352478661 4100 17174235
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.984926541268507 0.178549832244976 no 2826 0.162330077599958 4119 688798
SGTC_1213 1315-0166 115 µM -0.985956147391359 0.178300555285586 no 2827 0.162077316253971 4169 768401
SGTC_969 1313-0238 134 µM -0.986829053670129 0.178089388644203 no 2828 0.161863224542935 4096 5212874
SGTC_2671 danthron 100 µM -0.987366296425904 0.17795950150293 no 2829 0.161731550353707 4063 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3014 9081533 49.47 µM -0.988422096506656 0.177704418832458 no 2830 0.1614729850926 4113 21367265
SGTC_271 rotenone 740 µM -0.988560341916681 0.177671035650789 no 2831 0.161439148783459 4127 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2078 5212016 200 µM -0.990255146183315 0.177262099899136 no 2832 0.161024712120877 3935 1899708
SGTC_1028 k015-0029 4.8 µM -0.9904414314137 0.177217187813844 no 2833 0.160979201505851 4034 4588309
SGTC_2641 levomentholum 100 µM -0.992947696221972 0.176613643559818 no 2834 0.160367722141818 4076 16666
SGTC_728 3030-5151 22.5 µM -0.9943722636777 0.176271167510621 no 2835 0.160020833124269 4133 3125388
SGTC_224 benfluorex 43.875 µM -0.994896394771423 0.176145268530602 no 2836 0.159893328252461 4108 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_393 acivicin 6.25 µM -0.995925077196157 0.175898339256621 no 2837 0.159643274910537 3934 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_198 3454-2873 16.191 µM -0.999520548323881 0.175036990451795 no 2838 0.158771295012277 4070 710957
SGTC_3191 9110352 49.47 µM -0.999826522183809 0.174963813600521 no 2839 0.158697234125329 4028 17122424
SGTC_1942 st076330 65.2 µM -1.00220793354993 0.174394937792525 no 2840 0.15812158845029 4151 24208414
SGTC_1278 0874-0585 172 µM -1.00450297518332 0.173847807327371 no 2841 0.157568118949813 4152 766306
SGTC_2880 9042983 58.44 µM -1.00587421928355 0.173521428753714 no 2842 0.157238039587071 4103 6464714
SGTC_3132 9126706 49.47 µM -1.00616440946627 0.173452408759582 no 2843 0.157168244714588 4186 850858
SGTC_796 1234-0020 70.7 µM -1.00618067722728 0.173448540087534 no 2844 0.157164332689479 4018 46495034
SGTC_2734 clemastine 41.6 µM -1.00848418685058 0.172901291941841 no 2845 0.156611037686931 4132 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_793 0488-0545 106 µM -1.01151116432442 0.172183843285102 no 2846 0.155885920202387 4119 292548
SGTC_1182 1222-0449 220 µM -1.0131772725832 0.171789757173293 no 2847 0.15548774709129 4101 658318
SGTC_826 1683-5028 118 µM -1.01499427012506 0.171360638306055 no 2848 0.155054279423035 4144 722377
SGTC_540 1187-0821 17.3 µM -1.01503668832814 0.171350628624378 no 2849 0.155044169566492 4057 847520
SGTC_2211 7117706 200 µM -1.01543134504774 0.17125751699151 no 2850 0.154950128860085 4036 822771
SGTC_626 0214-0009 33 µM -1.01546608836047 0.171249321527289 no 2851 0.154941851860508 4173 3437874
SGTC_798 1287-0182 476 µM -1.01721863523677 0.170836245465925 no 2852 0.154524716431193 4155 1649755
SGTC_74 000s-0487 160.283 µM -1.01940875738788 0.170320929790925 no 2853 0.154004475163578 3999 677548
SGTC_299 1273-0059 1.44 µM -1.01988638990485 0.170208679629304 no 2854 0.153891172517336 3972 2848077
SGTC_1206 3978-0017 132 µM -1.02236369022406 0.16962724094611 no 2855 0.153304399554708 4208 3873677
SGTC_2823 7987624 58.44 µM -1.0240013135337 0.169243580347858 no 2856 0.152917327244279 4128 2239440
SGTC_1160 4092-0570 10.5 µM -1.02546969062393 0.168900044653526 no 2857 0.15257080982262 4113 4994975
SGTC_2478 5763493 32.33 µM -1.0259154391658 0.168795847787268 no 2858 0.152465722270341 4048 1365576 YLR208W SEC13
SGTC_362 0310-0100 9.03 µM -1.02648063896175 0.168663787751915 no 2859 0.15233254254297 4198 790235
SGTC_2678 equilin 100 µM -1.02656634713121 0.168643767671024 no 2860 0.152312353614206 4131 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3202 9113761 49.47 µM -1.02825182524694 0.168250376875056 no 2861 0.151915692892936 4120 4798415
SGTC_473 2-arachidonoylglycerol 10 µM -1.02830744997223 0.168237404127618 no 2862 0.151902613868459 3956 5282280 An endocannabinoid.
SGTC_519 k048-0011 62.8 µM -1.02836052275131 0.168225027142602 no 2863 0.1518901355797 4156 6836379
SGTC_2081 5214970 32.255 µM -1.02981779590092 0.167885408580357 no 2864 0.151547772611186 4078 2063512
SGTC_1364 1653-0028 37.6 µM -1.0306880463868 0.167682806715973 no 2865 0.15134356605478 4109 5718652
SGTC_3320 9137005 35.139 µM -1.03110255329825 0.167586361294455 no 2866 0.151246365292263 4144 4908713
SGTC_2791 5663188 71.43 µM -1.03120584888902 0.167562332549212 no 2867 0.151222149217354 4170 54690634
SGTC_334 1502-1024 68.5 µM -1.03235561600714 0.167295022178039 no 2868 0.150952777998157 4143 3296216
SGTC_2006 4011487 200 µM -1.03266428368463 0.167223306580236 no 2869 0.150880516728981 4167 45595294
SGTC_1794 st048918 76.9 µM -1.03737091598308 0.166132226968465 no 2870 0.149781513671003 4057 672303
SGTC_2091 4-phenylthiadiazole 200 µM -1.03882526856771 0.165796014834066 no 2871 0.149443003624763 4122 270010
SGTC_1470 k295-0292 231 µM -1.04044376398944 0.165422374233859 no 2872 0.149066889072768 4210 5045612
SGTC_2553 4-methylesculetin 85.09 µM -1.04162052771134 0.165151052676473 no 2873 0.148793823803456 4158 5319502
SGTC_2622 2-methoxyxanthone 59.94 µM -1.04452664020981 0.164482237145694 no 2874 0.148120900202656 4140 71034 A hepatoprotective.
SGTC_1040 k898-0338 155 µM -1.04590835238007 0.164164865204783 no 2875 0.147801673863259 4153 20969351
SGTC_2902 5787006 60.46 µM -1.05068416027712 0.163070948622379 no 2876 0.146701836636687 4103 591003
SGTC_2108 5365811 200 µM -1.05170861179395 0.162836912779515 no 2877 0.146466629350741 4154 780283
SGTC_1655 st012546 55.1 µM -1.05299334544148 0.162543724378621 no 2878 0.146172020990843 4142 720985 YLR208W SEC13
SGTC_2297 7971671 152.32 µM -1.05377663100339 0.162365139837013 no 2879 0.145992597508523 4161 909016
SGTC_44 0929-0055 61.211 µM -1.05463970995654 0.162168510813513 no 2880 0.145795067560058 4053 1379590
SGTC_1254 0550-0035 264 µM -1.05545988641798 0.161981799699304 no 2881 0.145607523098497 4197 15121435
SGTC_568 1193-0097 7.48 µM -1.05566123813495 0.161935983902551 no 2882 0.145561506110563 3988 3646150
SGTC_1401 3807-4679 7.6 µM -1.05652274648843 0.161740050662767 no 2883 0.145364727149329 4093 3291456
SGTC_1394 3474-0001 65.7 µM -1.05725727209861 0.161573119235801 no 2884 0.145197093978339 4159 5017666 YIL048W NEO1
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.06058930334694 0.160817278526128 no 2885 0.144438292914723 4096 97141
SGTC_3214 9129694 49.47 µM -1.0621428224865 0.160465667315007 no 2886 0.144085426142885 4209 17158655
SGTC_3197 9113331 49.47 µM -1.06243220868365 0.160400225473321 no 2887 0.144019759163471 4182 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1094 duloxetine 25.4 µM -1.06417952451357 0.160005457788673 no 2888 0.143623690385312 4166 60834 A selective serotonin reuptake inhibitor.
SGTC_1988 st071872 53.4 µM -1.06819797734681 0.159099989380621 no 2889 0.142715608485393 4189 16414116
SGTC_1898 st060199 18.6 µM -1.06850258895561 0.159031489111408 no 2890 0.142646931588358 4148 688866
SGTC_895 0964-0006 13.7 µM -1.07190660820409 0.158267316803339 no 2891 0.141880990897324 4132 6738897
SGTC_2405 ticlatone 3.52 µM -1.07319042629781 0.157979737723371 no 2892 0.141592842643229 4010 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1108 betulinic acid 729.144 nM -1.0737442294007 0.157855790160495 no 2893 0.141468666057578 4160 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3154 9100113 49.47 µM -1.07471294212546 0.157639134603906 no 2894 0.141251633788516 4176 25237525
SGTC_691 1548-0686 185 µM -1.07527024910853 0.157514579764379 no 2895 0.141126875992206 4158 46495133
SGTC_2050 5263056 171 µM -1.07760667382114 0.156993106641026 no 2896 0.140604661315411 4166 763468 YGL055W OLE1
SGTC_2247 cerulenin 830 nM -1.07824340752901 0.156851189420718 no 2897 0.140462572574271 4229 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1079 idarubicin 2.36 µM -1.07873681755964 0.156741274703518 no 2898 0.140352533938266 4181 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_128 0906-2981 13.371 µM -1.08101379494665 0.156234699661141 no 2899 0.139845488663408 4163 6740226
SGTC_2519 cryptotanshinone 88.04 µM -1.08184129738826 0.1560508669343 no 2900 0.139661526378981 4153 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2708 st078559 56 µM -1.0818481496625 0.156049345271583 no 2901 0.139660003735332 4114 17250902
SGTC_2449 5812982 45.77 µM -1.08359710628507 0.155661279807604 no 2902 0.139271737212771 4109 776185
SGTC_2444 5485484 36.41 µM -1.08572322278689 0.155190386486304 no 2903 0.138800731595708 4255 6790631
SGTC_304 1310-0298 97 µM -1.08659817535999 0.154996874965898 no 2904 0.138607215900155 3981 1550234
SGTC_495 decylubiquinone 155 µM -1.08691172937629 0.154927565648815 no 2905 0.13853791104593 4242 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3057 9095946 49.47 µM -1.08718302547455 0.154867613722239 no 2906 0.138477965516628 4229 24540043
SGTC_2038 4100038 30.985 µM -1.08732544778722 0.154836146894198 no 2907 0.138446502988446 4167 3596803
SGTC_621 3584-0052 32.1 µM -1.09144433015222 0.153927947155377 no 2908 0.137538707595025 4194 2273927
SGTC_1510 1123-0200 71.5 µM -1.09411517157723 0.153340923431629 no 2909 0.136952234628143 4237 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_866 0495-0101 262 µM -1.09503229279489 0.15313969206635 no 2910 0.136751244599309 4169 635694
SGTC_2904 7225135 42.03 µM -1.09557732997599 0.153020184963165 no 2911 0.136631893547104 4293 4446116
SGTC_501 nsc-95397 161 µM -1.10109626867458 0.151813562794835 no 2912 0.135427380417652 4229 262093
SGTC_2889 9059656 51.95 µM -1.10203755221701 0.151608399954948 no 2913 0.135222673136866 4267 3949838
SGTC_2691 st077356 60.2 µM -1.10469540136373 0.151030088566263 no 2914 0.1346457983574 4247 2839272
SGTC_2502 avocadyne acetate 18.59 µM -1.10857878871154 0.150187759626598 no 2915 0.133805966369495 4137 3952079
SGTC_266 formosanin C 406 nM -1.11432414982371 0.148947311672444 no 2916 0.132570075116332 4083 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_162 k030-0015 37.8 µM -1.11474324458329 0.148857095967931 no 2917 0.132480231924448 4280 1809920 YMR134W ERG29
SGTC_2206 7254556 146.969 µM -1.11810676040392 0.148134377243303 no 2918 0.13176069972999 4216 4398905
SGTC_471 1-acyl-paf 4 µM -1.12015882887589 0.147694604378413 no 2919 0.131323042519632 4148 16759367
SGTC_805 3852-0218 479 µM -1.12440245244225 0.146787941937397 no 2920 0.130421166066033 4180 6615355
SGTC_2079 5212404 121 µM -1.12535292079927 0.146585384529806 no 2921 0.130219756305536 4190 758462
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.12626483191613 0.146391220593866 no 2922 0.130026719439044 4107 17037758
SGTC_2860 9025725 38.96 µM -1.12771830612946 0.146082104236085 no 2923 0.129719452010543 4253 40546248
SGTC_1174 0739-0097 51.1 µM -1.12783007281265 0.14605835252312 no 2924 0.129695845142975 4253 728447
SGTC_2260 7964312 200 µM -1.12974870016286 0.14565102654996 no 2925 0.129291065002411 4280 231951
SGTC_1420 4'-methoxyflavone 42 µM -1.13132354739501 0.145317256593354 no 2926 0.128959468431209 4216 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1855 st056195 39.6 µM -1.13594543919955 0.144340675117406 no 2927 0.127989699798421 4171 4028379
SGTC_1265 0819-1001 68.8 µM -1.13648485869228 0.144226987540383 no 2928 0.127876849450553 4173 3106768
SGTC_1504 k297-0033 30 µM -1.13944283845186 0.143604639623685 no 2929 0.127259248514311 4113 4388117
SGTC_2805 7950783 58.44 µM -1.13955104344277 0.143581908113157 no 2930 0.127236695644554 4250 1178958 YDL195W SEC31
SGTC_222 nsc-310342 10.666 µM -1.14166118237181 0.143139099389782 no 2931 0.126797440939891 4247 432556
SGTC_284 0988-0104 32.6 µM -1.14248644311121 0.142966171171701 no 2932 0.126625939002596 4222 4666532
SGTC_1382 3002-2117 298 µM -1.14330217809818 0.142795377809624 no 2933 0.126456575500669 4304 1497314
SGTC_916 4466-0038 42 nM -1.14418621810276 0.142610438968842 no 2934 0.126273208722895 4289 5722064 YGL116W CDC20
SGTC_2586 curcumin 80 µM -1.14419892973783 0.142607780909979 no 2935 0.126270573439135 4153 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2098 5376439 882.5 nM -1.14515098955376 0.142408796223557 no 2936 0.126073308249937 4279 2844116
SGTC_153 4077-0274 519.67 µM -1.14632853495617 0.142162943981837 no 2937 0.125829620165044 4279 3121976
SGTC_1985 st071382 65.5 µM -1.14885574279166 0.141636274524399 no 2938 0.125307734755161 4227 6123237
SGTC_2883 9059145 45.46 µM -1.15082196248146 0.141227430201026 no 2939 0.124902743747242 4236 16476510
SGTC_174 3553-0389 74.3 µM -1.15268763373565 0.140840233800534 no 2940 0.124519309502264 4323 738071
SGTC_2486 5283202 22.39 µM -1.15272386362035 0.140832721883262 no 2941 0.124511871662014 4282 1377751
SGTC_2220 6782180 200 µM -1.1535192186992 0.140667881161172 no 2942 0.124348666922027 4159 833803
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.15688505260143 0.139971747721391 no 2943 0.123659663205305 4245 688669
SGTC_1433 4060-0023 7.6 µM -1.15711199432085 0.139924895239249 no 2944 0.123613303441774 4267 3840627
SGTC_1019 4262-0212 3.4 µM -1.16023932226226 0.139280338754243 no 2945 0.122975690648562 4265 4677213
SGTC_514 4466-0038 2.65 nM -1.16051192833961 0.139224249287356 no 2946 0.122920220030017 4063 5722064
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.16105528684968 0.139112497603568 no 2947 0.122809708316408 4251 1377
SGTC_669 0108-0021 26.2 µM -1.16160667410482 0.138999157090288 no 2948 0.122697634914279 4219 17201
SGTC_1827 berberine 7.24 µM -1.16621181266444 0.138055002199422 no 2949 0.121764408864729 4173 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1777 st045864 34.765 µM -1.16942380877254 0.137399067167097 no 2950 0.121116460980815 4247 4691462
SGTC_670 4204-0025 119 µM -1.17001618253864 0.137278328870716 no 2951 0.120997228305913 4276 719039
SGTC_2864 9034755 47.6 µM -1.17225621070785 0.136822418981592 no 2952 0.120547103329635 4189 4930451
SGTC_553 k007-0256 45.7 µM -1.17332330068111 0.13660559996587 no 2953 0.120333090888301 4319 6287000
SGTC_1312 1218-2183 165 µM -1.17707789428279 0.135844583007751 no 2954 0.11958220867606 4321 6744073
SGTC_2848 9016370 25.97 µM -1.18025180930936 0.13520353202717 no 2955 0.118950039309847 4267 7894410
SGTC_3029 9088683 49.47 µM -1.1824992044378 0.134750870926909 no 2956 0.118503840502195 4291 25236615
SGTC_1952 st077036 64.1 µM -1.18298004480093 0.134654157240136 no 2957 0.118408528066659 4285 2937007
SGTC_383 2324-0395 7.37 µM -1.18538676185164 0.134170798931093 no 2958 0.117932281710297 4264 3146421
SGTC_3142 9086498 49.47 µM -1.1896778556809 0.1333119475777 no 2959 0.117086516120469 4145 25236367
SGTC_24 0417-1663 219 µM -1.19721646395398 0.131812290356139 no 2960 0.115611097152227 4313 4329390
SGTC_2729 fluphenazine 10.66 µM -1.20161676778821 0.130942336294213 no 2961 0.114756020957001 4216 3372 An atypical antipsychotic.
SGTC_1141 3253-0389 52.6 µM -1.20469812593049 0.130335508946627 no 2962 0.114159929887265 4287 5402031
SGTC_3244 9134489 49.47 µM -1.20498440597963 0.130279229306858 no 2963 0.114104660965631 4301 16584271
SGTC_932 2857-0803 154 µM -1.20854643250838 0.129580378344615 no 2964 0.113418573424193 4327 674898
SGTC_1930 st074634 34.3 µM -1.21327998897236 0.128655704149901 no 2965 0.112511395504005 4196 684253 YOR116C RPO31
SGTC_2147 5545932 89.7195 µM -1.21343282001625 0.128625925941824 no 2966 0.11248219232399 4336 797404
SGTC_3053 9095903 49.47 µM -1.21348528265965 0.128615705014645 no 2967 0.112472168933665 4416 17174018
SGTC_1646 st011709 75.6 µM -1.21381857397034 0.128550785380751 no 2968 0.112408505975951 4261 5757843
SGTC_2925 9010536 32.5 µM -1.2146620794927 0.128386586083086 no 2969 0.112247500537397 4224 2994177
SGTC_2475 5812728 15.03 µM -1.21557596114201 0.128208851556611 no 2970 0.112073248029311 4237 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_68 0986-0284 82.829 µM -1.21864954128618 0.127612346244181 no 2971 0.111488618558367 4336 423278 YIL048W NEO1
SGTC_693 4161-2696 114 µM -1.22289725772027 0.126791150373936 no 2972 0.110684252230719 4348 805759
SGTC_2202 7226349 200 µM -1.2232370807447 0.126725612913931 no 2973 0.110620081975777 4277 844334
SGTC_3121 9125696 49.47 µM -1.22911349221036 0.125596031970897 no 2974 0.109514628589299 4417 1235365
SGTC_3225 9130819 49.47 µM -1.2314608152756 0.125146792270418 no 2975 0.109075281744214 4267 4547121
SGTC_1972 st070201 17.4 µM -1.23180572284961 0.125080877208493 no 2976 0.109010832519867 4319 2829099
SGTC_3092 9117248 49.47 µM -1.23385098538684 0.124690506629046 no 2977 0.108629218330656 4439 17141857
SGTC_3087 9117406 49.47 µM -1.23567440593036 0.124343196754883 no 2978 0.108289807413657 4344 42546093
SGTC_1830 st055982 50.3 µM -1.24214534676065 0.123116129107905 no 2979 0.107091470043275 4294 455313 An antimicrobial agent.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.24344832106555 0.122870079582582 no 2980 0.106851336697343 4276 6708739 YPR165W RHO1
SGTC_2384 9036245 200 µM -1.24394734237222 0.122775937364531 no 2981 0.106759471880184 4249 6462766
SGTC_1138 3761-0006 1.03 µM -1.246631444965 0.122270439319052 no 2982 0.106266333158925 4352 12061087
SGTC_457 grayanotoxin iii 135 µM -1.24707317610685 0.12218738813479 no 2983 0.106185333693918 4172 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_319 1348-1596 45.5 µM -1.25078383758199 0.121491299209575 no 2984 0.105506676578564 4408 5380505
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.25080458546274 0.121487414934486 no 2985 0.105502890758608 4340 77254
SGTC_3038 9091290 49.47 µM -1.25292577812925 0.121090760491396 no 2986 0.105116359730527 4352 25236843
SGTC_2612 dictamnine 15.46 µM -1.25439197526014 0.12081712061225 no 2987 0.104849783946663 4254 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1211 1056-0033 32.3 µM -1.25729958034164 0.12027575531784 no 2988 0.104322587951591 4386 6741922
SGTC_970 1315-0089 19.5 µM -1.25882098570203 0.119993167797232 no 2989 0.104047499290129 4287 6811083 YLR033W RSC58
SGTC_775 4577-0580 57.3 µM -1.25933630472309 0.119897558055196 no 2990 0.103954442670316 4369 2006902
SGTC_2275 7947463 200 µM -1.25996535841437 0.119780919355551 no 2991 0.103840929600762 4298 1225414
SGTC_1689 st020265 53.493 µM -1.26293924503598 0.119230586636029 no 2992 0.10330550732663 4345 5758320 YPR016C TIF6
SGTC_1886 st057356 49.9 µM -1.26415054015243 0.119006942648341 no 2993 0.10308799966717 4318 24207747
SGTC_191 3914-0123 66.505 µM -1.26611139618584 0.118645533800781 no 2994 0.102736601560312 4356 3144412
SGTC_928 2764-0428 58.7 µM -1.26656619703456 0.118561819559984 no 2995 0.102655222814893 4367 662578
SGTC_809 3998-0021 90 µM -1.26887168970083 0.118138094467512 no 2996 0.102243415477523 4289 715485
SGTC_1960 st011366 51.8 µM -1.27083965299507 0.117777251853114 no 2997 0.101892849376709 4367 3972846
SGTC_1915 st067105 30.6 µM -1.27517667422479 0.116984777802607 no 2998 0.101123357728505 4284 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3190 9110366 49.47 µM -1.27619062636981 0.116800051558635 no 2999 0.100944070688913 4345 17123768
SGTC_2701 st077767 14.721 µM -1.27656336754479 0.116732195945737 no 3000 0.100878220873227 4324 5721188
SGTC_1080 nisoldipine 24.4 µM -1.27673273810937 0.116701372142969 no 3001 0.100848309602808 4350 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3348 9149464 3.537 µM -1.2778037535702 0.116506591322114 no 3002 0.100659315291202 4284 1951442
SGTC_2036 5160441 105 µM -1.27780797395954 0.116505824235044 no 3003 0.100658571061134 4321 134534 YIL048W NEO1
SGTC_1144 3486-0183 12.5 µM -1.27828313592688 0.116419482926951 no 3004 0.100574805916796 4361 6744069
SGTC_2777 climbazole 1.536 µM -1.27958391485764 0.116183351650948 no 3005 0.100345754942962 4180 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1355 1499-0035 1.68 µM -1.2797629081803 0.116150885494885 no 3006 0.100314266268221 4350 1548538
SGTC_1933 st074711 15.9 µM -1.28247882963425 0.11565905628514 no 3007 0.0998373633749964 4327 17250958
SGTC_2893 9048488 25.97 µM -1.28864881975746 0.114547228480706 no 3008 0.098760101451922 4384 6467338
SGTC_2106 5357045 167.29 µM -1.28985942383162 0.114329974211614 no 3009 0.0985497356012907 4372 668842
SGTC_715 0868-0130 184 µM -1.29185424019128 0.11397262600737 no 3010 0.0982038136512518 4411 2876258
SGTC_1343 1487-0095 224 µM -1.29415758474228 0.113560999333803 no 3011 0.0978054971299977 4362 4560101 YGL055W OLE1
SGTC_3141 9094609 49.47 µM -1.30254284673067 0.112071440034423 no 3012 0.0963654404498372 4329 25236309 YDL196W YDL196W
SGTC_2869 9037858 32.47 µM -1.30276238998287 0.112032628866172 no 3013 0.0963279472789033 4337 27187042
SGTC_1492 4158-0558 28.5 µM -1.30383164804974 0.111843741271864 no 3014 0.0961454947120322 4378 3967268
SGTC_1546 5-methoxyflavanone 78.7 µM -1.30458306320765 0.111711137904011 no 3015 0.0960174292729797 4383 147795
SGTC_3339 9145883 14.936 µM -1.30820911010021 0.111072824711964 no 3016 0.0954011964756583 4284 2030670
SGTC_1143 3454-2408 5.08 µM -1.31038057053015 0.110691823191059 no 3017 0.0950335615679709 4381 X1143
SGTC_1720 st037298 9.481 µM -1.31132535007473 0.110526346171229 no 3018 0.0948739336864731 4361 597396
SGTC_2227 7312221 64.1025 µM -1.31731016354079 0.109482231872784 no 3019 0.0938673399014545 4490 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_739 1486-1183 203 µM -1.32011169400626 0.108995916675563 no 3020 0.0933988645009945 4382 4346692
SGTC_1100 amiodarone 5.07 µM -1.32504309075697 0.108143655665717 no 3021 0.0925784298270242 4422 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3316 9136639 10.545 µM -1.32616595877137 0.10795027006695 no 3022 0.0923923660974981 4369 4903665
SGTC_330 1488-0319 80.1 µM -1.32817150851758 0.107605484727684 no 3023 0.0920607272193807 4418 6846614
SGTC_607 4491-0986 66.8 µM -1.32878005174256 0.107501023719719 no 3024 0.0919602726605204 4385 698981 YDR232W HEM1
SGTC_868 0527-0199 213 µM -1.32899416550416 0.10746428687338 no 3025 0.0919249473943097 4347 2849450
SGTC_2177 5811945 192 µM -1.32999466288004 0.107292745159382 no 3026 0.0917600148890252 4408 5343475
SGTC_171 k064-0041 9.68 µM -1.33127941380479 0.107072755977904 no 3027 0.091548544665481 4379 53325
SGTC_524 r073-0010 27.8 µM -1.33437857391138 0.106543423026114 no 3028 0.0910399091733682 4325 2772106
SGTC_566 0958-0068 16.5 µM -1.34627652533129 0.104528817217594 no 3029 0.0891066767547708 4294 6815365
SGTC_1354 1498-1681 81 µM -1.35094918629902 0.103745219569138 no 3030 0.0883558552979065 4382 5754243
SGTC_1402 3909-7673 35.9 µM -1.35312781097544 0.103381327952394 no 3031 0.0880074011492075 4417 5328014
SGTC_1017 4239-0030 168 µM -1.35373443754338 0.103280169358874 no 3032 0.0879105585503893 4424 1149593
SGTC_1929 genistein trimethyl ether 50.5 µM -1.35503461666119 0.10306359887241 no 3033 0.0877032641268118 4377 136420
SGTC_1736 st036774 51 µM -1.35535188903207 0.103010801000673 no 3034 0.0876527351124493 4452 1272247
SGTC_1856 st057054 55.7 µM -1.35640238047663 0.102836127035253 no 3035 0.0874855881434709 4404 1266018
SGTC_1550 gossypolone 36.6 µM -1.35679410096749 0.10277104752594 no 3036 0.0874233212032283 4442 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1505 k297-0037 20.6 µM -1.35842635119489 0.10250019154433 no 3037 0.0871642187264206 4399 4089396
SGTC_760 0568-0725 82.9 µM -1.35944986058655 0.102330615128647 no 3038 0.0870020402075231 4418 3916171
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.35951573624666 0.102319707753232 no 3039 0.086991609712234 4367 688761
SGTC_515 4092-1064 102 µM -1.36071771073802 0.102120839031887 no 3040 0.086801457729747 4389 717353
SGTC_2703 st077852 53.4 µM -1.36225135230321 0.101867503929536 no 3041 0.086559287288711 4435 6281836
SGTC_252 miconazole 1.30953 nM -1.3643650111049 0.101519108557612 no 3042 0.0862263571143178 4308 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2867 9039098 71.43 µM -1.36515507607186 0.101389104841016 no 3043 0.0861021572993535 4382 6463460
SGTC_2395 5646831 180.19 µM -1.36938325949222 0.100695425996391 no 3044 0.0854397521649915 4401 6808628
SGTC_2096 5468907 200 µM -1.36953243906168 0.100671014863297 no 3045 0.0854164509661519 4409 759785
SGTC_53 0973-0023 39.979 µM -1.370571502881 0.100501106445966 no 3046 0.0852542857419964 4310 674768
SGTC_1055 3448-0672 86 µM -1.37569280263682 0.0996667244147226 no 3047 0.0844583805888685 4394 748378
SGTC_1678 st019265 80.2 µM -1.37594535661451 0.0996257086897982 no 3048 0.0844192757037557 4405 5367020
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.37614931099959 0.099592594726359 no 3049 0.0843877057858497 4369 279621
SGTC_2584 androsterone 48.74 µM -1.37843861149025 0.0992214563787636 no 3050 0.0840339545572198 4330 2754130 A steroid.
SGTC_1075 aripiprazole 15.2 µM -1.381625630304 0.0987064665608587 no 3051 0.0835433400312783 4477 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3256 9138902 49.47 µM -1.3826032885985 0.0985488797189132 no 3052 0.0833932700795271 4524 17228773
SGTC_2783 7738165 71.43 µM -1.38571383921702 0.098048721463194 no 3053 0.0829171503247422 4407 17201110
SGTC_3034 9090421 49.47 µM -1.38631021135518 0.0979530411909549 no 3054 0.0828261000632234 4340 17173761
SGTC_1742 st038235 28.8875 µM -1.38947031939114 0.0974471840764745 no 3055 0.0823448901175201 4454 564103 YBR002C RER2
SGTC_707 0865-0008 204 µM -1.39000226560211 0.0973622210776576 no 3056 0.0822640946900282 4462 723043
SGTC_874 0599-0792 117 µM -1.39180161104359 0.0970752305837479 no 3057 0.0819912409977008 4424 765305
SGTC_2 0422-0095 29 µM -1.39380890086301 0.0967558067883515 no 3058 0.0816876597956579 4325 6790840
SGTC_3125 9127534 49.47 µM -1.39478110300038 0.0966013761866754 no 3059 0.0815409295304214 4339 1639235
SGTC_2048 5246248 200 µM -1.39555804206972 0.0964780926044019 no 3060 0.0814238124230415 4443 677046
SGTC_2854 9024559 71.43 µM -1.39885039071794 0.0959569501881396 no 3061 0.0809289258704573 4444 3163529
SGTC_1922 5578187 25 µM -1.39901219519522 0.0959313918020701 no 3062 0.080904663035291 4439 1350412
SGTC_3175 9106517 49.47 µM -1.40609705630994 0.0948171817515135 no 3063 0.0798476531905566 4440 41468073
SGTC_1792 st045773 43.6 µM -1.40771080086579 0.0945647328035709 no 3064 0.079608361131699 4406 2919270
SGTC_1498 4478-3555 97.6 µM -1.41278732583194 0.0937738092189702 no 3065 0.0788591329669658 4434 3437919
SGTC_2480 5767542 37.17 µM -1.4150750788016 0.0934189773686995 no 3066 0.0785232420883728 4367 2867358
SGTC_1483 3453-0561 55.9 µM -1.41514844144019 0.0934076152140625 no 3067 0.0785124888643884 4480 4546991
SGTC_2157 5649910 96.377 µM -1.41626339068559 0.0932350613142357 no 3068 0.0783492011013891 4425 2858091
SGTC_778 3456-2434 196 µM -1.41969697131234 0.0927051466410351 no 3069 0.0778479601248333 4375 5539063
SGTC_138 0850-0259 40.9225 µM -1.42103371754068 0.0924994461619411 no 3070 0.0776534787422657 4384 6813004
SGTC_2661 dactinomycin 12.96 µM -1.42302205555882 0.0921941027722025 no 3071 0.0773648808387115 4420 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1860 st056228 74.6 µM -1.42399632494468 0.0920447596556764 no 3072 0.0772237679580318 4437 688679
SGTC_538 2922-0838 53.3 µM -1.42759937701562 0.0914940136209764 no 3073 0.0767036015206118 4471 777039
SGTC_2340 7987427 183.45 µM -1.42957864270648 0.0911925133828186 no 3074 0.0764189944444597 4453 2239331
SGTC_2832 7992762 51.95 µM -1.43110586818001 0.0909603761632647 no 3075 0.0761999378679349 4393 2985177
SGTC_1427 4048-4900 550 nM -1.43574933147112 0.0902572658130945 no 3076 0.0755368411636924 4439 24132586
SGTC_3234 9132280 49.47 µM -1.43800686959353 0.0899168926891001 no 3077 0.0752160525034075 4481 17612295
SGTC_3298 9116858 71.43 µM -1.44576403297724 0.0887546011999624 no 3078 0.0741216986850182 4523 2506942
SGTC_3337 9144342 33.5465 µM -1.45277195683472 0.0877142244009 no 3079 0.0731435402798219 4459 17682949
SGTC_352 k048-0007 5.11 µM -1.45618486301177 0.0872108603104913 no 3080 0.0726707614237798 4399 6811911
SGTC_1337 1486-1011 40.3 µM -1.45750819990452 0.0870162648454878 no 3081 0.0724880747691713 4459 X1337
SGTC_1282 0886-0010 32.4 µM -1.45897174887372 0.0868014292154631 no 3082 0.0722864417674561 4491 2836211 YNL267W PIK1
SGTC_1494 4358-1428 177 µM -1.45918115412226 0.0867707228748183 no 3083 0.0722576272082914 4491 1564571
SGTC_1990 st072050 59.8 µM -1.46308873782694 0.086199218582577 no 3084 0.0717215495650989 4462 17233948
SGTC_1009 4106-0057 9.87 µM -1.46383670826003 0.086090145828407 no 3085 0.0716192849855755 4474 2928005
SGTC_1453 4237-0541 195 µM -1.46393483810583 0.0860758437134169 no 3086 0.0716058767079755 4475 739892
SGTC_2793 7325131 81.82 µM -1.4664427013109 0.085710933546416 no 3087 0.0712638601815726 4427 4176441
SGTC_2673 kobusone 100 µM -1.46995584294294 0.0852016981512068 no 3088 0.0707868568488329 4581 6710676 An epoxy ketone and protein crosslinker.
SGTC_2645 abamectin 100 µM -1.47143455274001 0.0849880360460095 no 3089 0.0705868173946323 4426 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.47430686750342 0.0845741569754376 no 3090 0.0701994934822519 4455 442882
SGTC_1464 k208-0027 110 µM -1.47772085993821 0.0840841948149062 no 3091 0.0697412543073986 4483 X1464
SGTC_1643 st009866 20.2 µM -1.47821967807105 0.0840127852760107 no 3092 0.0696744942480944 4441 3156273 YOR207C RET1
SGTC_827 3253-0474 693 µM -1.48019796567576 0.0837300270003099 no 3093 0.0694102115927535 4477 5402065
SGTC_1958 st076513 41.9 µM -1.48076322247301 0.0836493658463696 no 3094 0.0693348400170221 4418 732122 YGL099W LSG1
SGTC_1814 st052110 31.539 µM -1.48340044695595 0.0832738099779072 no 3095 0.0689840243774704 4418 674163
SGTC_2125 5246583 200 µM -1.48760807529618 0.0826772463294278 no 3096 0.06842714128482 4486 835267
SGTC_609 0986-0026 86.3 µM -1.48807095623712 0.0826118152756044 no 3097 0.0683660909833085 4478 2848610
SGTC_2702 st077768 96.8 µM -1.49295331535085 0.0819240358725962 no 3098 0.0677247038199087 4458 6484119
SGTC_649 1123-0311 367 µM -1.49556805310453 0.0815574757052848 no 3099 0.0673831267248128 4393 693629 YIL048W NEO1
SGTC_1859 st055998 20 µM -1.49674948972577 0.0813922562862452 no 3100 0.0672292268147054 4419 676301
SGTC_1217 1183-1422 255 µM -1.49717698858483 0.0813325344395092 no 3101 0.0671736056590613 4521 2849664
SGTC_2076 5212012 200 µM -1.49740995259213 0.0813000031464425 no 3102 0.0671433100869295 4474 604802
SGTC_3310 9130229 44.1445 µM -1.4976093810855 0.0812721625801575 no 3103 0.0671173840017779 4509 7761258
SGTC_1455 4262-0120 131 µM -1.50569138977639 0.0801499425213954 no 3104 0.0660732076607301 4536 1529587
SGTC_2776 terbinafine 19.92 µM -1.50937350828284 0.0796425659713333 no 3105 0.0656016795642222 4502 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.50993256711084 0.0795657435606962 no 3106 0.065530315813899 4454 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_469 w7 172 µM -1.51667217172731 0.0786440361873784 no 3107 0.0646747368267653 4599 45115570 A P450 inhibitor.
SGTC_2127 5253358 187.912 µM -1.52043400306025 0.0781330997961235 no 3108 0.0642009669689774 4432 20612
SGTC_2887 9044784 58.44 µM -1.52613293542494 0.0773638662616422 no 3109 0.063488380601999 4433 6465546
SGTC_1811 st050069 61.5 µM -1.52806502119409 0.0771043860496041 no 3110 0.063248197528943 4502 3877702
SGTC_2635 hydroquinidine 100 µM -1.52884763585904 0.076999468858079 no 3111 0.0631511100346317 4441 442912 An experimental heart treatment.
SGTC_1367 1812-0510 76.9 µM -1.53025663141983 0.0768108527285968 no 3112 0.0629766092786124 4566 1142582 YDR527W RBA50
SGTC_3349 9149703 23.001 µM -1.53576596776544 0.0760767127694616 no 3113 0.0622978946201006 4530 4910494
SGTC_3265 9137266 49.47 µM -1.5370202757495 0.0759103204103423 no 3114 0.0621441721343726 4490 17224265
SGTC_2710 st078562 53.7235 µM -1.54007390000521 0.0755063954059952 no 3115 0.0617711704736903 4484 17250908
SGTC_623 k072-0108 16.9 µM -1.54025004184682 0.0754831459074 no 3116 0.061749708094251 4490 5382803
SGTC_2118 5526350 200 µM -1.54130639768125 0.0753438287316974 no 3117 0.0616211162820095 4513 743594
SGTC_2877 9040724 71.43 µM -1.54169858119343 0.075292155646317 no 3118 0.0615734284444925 4483 6463895
SGTC_342 k048-0088 23.3 µM -1.54553124503897 0.0747885949405785 no 3119 0.0611089086487993 4514 6820570
SGTC_1658 st012944 20 µM -1.5462830787118 0.0746901162332697 no 3120 0.0610181083893742 4368 24207260
SGTC_1224 0823-0416 294 µM -1.54677345295431 0.0746259380503724 no 3121 0.0609589418894513 4548 3598164
SGTC_1310 1188-0297 994 nM -1.54696340550601 0.0746010891465367 no 3122 0.0609360350664624 4401 1588352
SGTC_1729 st035615 45.989 µM -1.55110783180625 0.0740605010165215 no 3123 0.0604379223225557 4516 17385451
SGTC_1368 1852-0141 284 µM -1.55329174066141 0.0737768442559362 no 3124 0.0601767262759761 4504 2838987
SGTC_3290 9121031 71.43 µM -1.55426302280596 0.0736509564793863 no 3125 0.0600608449699212 4520 17014854
SGTC_217 ketoconazole 989 nM -1.55608544720859 0.0734151954672971 no 3126 0.0598438875320474 4325 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1149 3909-7961 23.3 µM -1.55664707351028 0.0733426562013549 no 3127 0.0597771504866239 4571 735261
SGTC_1078 idebenone 36.1 µM -1.55932001602454 0.0729981719579979 no 3128 0.0594603282849116 4544 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2991 9074669 71.4286 µM -1.56156477588541 0.0727098290179646 no 3129 0.059195276463125 4486 17333109
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.56292176203458 0.0725359454682019 no 3130 0.0590354991561296 4497 1241132 A phosphatase inhibitor.
SGTC_75 0159-0059 199.013 µM -1.56315812453813 0.0725056906909777 no 3131 0.0590077034599084 4573 5377270
SGTC_122 0236-0016 402.397 µM -1.56506796777314 0.0722615822254453 no 3132 0.0587834866875135 4522 6808838
SGTC_3326 9140064 16.379 µM -1.56678986095428 0.0720420371367773 no 3133 0.0585819090479925 4482 1868434
SGTC_2049 5262831 67.185 µM -1.5677604370301 0.0719185121573855 no 3134 0.0584685255777688 4479 763417
SGTC_1393 3470-5649 58.2 µM -1.56940926097352 0.0717090391346256 no 3135 0.058276303767091 4527 4108395
SGTC_1155 4088-0394 48.2 µM -1.56950268194287 0.071697184595311 no 3136 0.0582654275196737 4527 2326248
SGTC_843 0310-0051 143 µM -1.57271642607131 0.071290295207925 no 3137 0.0578922473189215 4545 2065037
SGTC_193 1273-0060 1.558 µM -1.57309263974447 0.0712427792526013 no 3138 0.0578486844828883 4382 2847393 YHR072W ERG7
SGTC_2144 5628481 200 µM -1.5749518706011 0.0710083144766917 no 3139 0.0576337771741626 4518 2818399
SGTC_2950 9072895 21.46 µM -1.57497966116306 0.0710048143521023 no 3140 0.0576305696500009 4475 17332245
SGTC_2333 9017922 200 µM -1.5756323969774 0.0709226426487047 no 3141 0.0575552727153358 4531 3163164
SGTC_3158 9100007 49.47 µM -1.57831165845651 0.0705861204879866 no 3142 0.0572470144388968 4544 19297233
SGTC_420 mitomycin C 81.9 mM -1.58315346095296 0.0699810923205178 no 3143 0.056693245476115 4512 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_329 k048-0121 21.3 µM -1.58686202569862 0.0695203774660343 no 3144 0.0562719485891048 4543 6832902
SGTC_368 fentichlor 4.58 µM -1.58905298718777 0.069249293997957 no 3145 0.0560242152275854 4526 7329 A pesticide.
SGTC_2338 7999974 200 µM -1.58952450437879 0.0691910607082332 no 3146 0.0559710131374475 4520 315925
SGTC_2674 ligustilide 100 µM -1.60081584550581 0.0678077998725774 no 3147 0.0547088564828935 4596 5319022 A signalling regulator.
SGTC_1465 k213-0056 144 µM -1.60246028342769 0.0676081402013503 no 3148 0.054526931701179 4468 24048857 YMR208W ERG12
SGTC_1815 st051655 58.2 µM -1.60390720160698 0.0674328383561931 no 3149 0.0543672545889597 4504 5984156
SGTC_3161 9100388 49.47 µM -1.60434007878808 0.0673804613091436 no 3150 0.0543195556480785 4623 25236368
SGTC_1366 1683-0113 21.9 µM -1.60673560152638 0.0670911774273721 no 3151 0.0540561901709665 4557 708623
SGTC_1559 coumarin 343 70.1 µM -1.61962063310482 0.0655516265088719 no 3152 0.0526568972858978 4594 108770 A hepatotoxic, DNA x-linker.
SGTC_2686 alizarin 95.37 µM -1.62370428778363 0.0650694563535944 no 3153 0.0522194677410444 4525 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1534 6-azauridine 81.6 µM -1.62381735295382 0.0650561456535631 no 3154 0.0522073977022811 4589 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1567 st069303 68.4 µM -1.62654631157828 0.0647355171475412 no 3155 0.0519167449273977 4560 5581319
SGTC_922 1866-0035 480 µM -1.62667315111838 0.0647206445200184 no 3156 0.0519032669819005 4503 3156169
SGTC_1165 k072-0275 30.3 µM -1.62752165228497 0.0646212213705911 no 3157 0.0518131769073251 4546 6153523 YGL055W OLE1
SGTC_1324 1418-0026 34.4 µM -1.63156464122707 0.0641491124976252 no 3158 0.0513856160240535 4578 1372513
SGTC_934 2950-0684 338 µM -1.63373254073679 0.0638970686771368 no 3159 0.0511575112424073 4563 1121253
SGTC_135 0933-0004 26.348 µM -1.63825026112174 0.0633743058848964 no 3160 0.0506847493956305 4488 21230617 YGL099W LSG1
SGTC_949 1165-0505 146 µM -1.63936197499272 0.0632461770260838 no 3161 0.050568947962758 4531 6244267
SGTC_1509 1326-1131 80 µM -1.64182592308081 0.0629629174691046 no 3162 0.050313042549136 4545 768313
SGTC_727 3032-0951 202 µM -1.64779736374313 0.0622805306867547 no 3163 0.0496971301010536 4591 3652836
SGTC_3302 9125395 16.351 µM -1.64860149100015 0.0621890813452921 no 3164 0.0496146515416634 4526 17599668
SGTC_382 3229-0966 23.2 µM -1.64874662322767 0.062172587352483 no 3165 0.0495997771115976 4587 5722370
SGTC_1423 4048-0112 5.59 µM -1.64999408985792 0.0620309559112646 no 3166 0.0494720724368287 4616 X1423
SGTC_63 0099-0242 26.702 µM -1.65062831851734 0.0619590451977083 no 3167 0.0494072463879598 4579 3898502 YLR359W ADE13
SGTC_2485 5633444 17.78 µM -1.65190520466322 0.0618144654357537 no 3168 0.0492769384608442 4532 5724239
SGTC_384 k007-0144 5.16 µM -1.6519665802964 0.0618075226106176 no 3169 0.0492706819148591 4534 6824886
SGTC_2926 9010726 65.15 µM -1.65636591743627 0.0613114523078981 no 3170 0.0488238694182038 4550 2994293
SGTC_2250 alverine citrate 130 µM -1.66188361951444 0.0606936786109694 no 3171 0.0482680558361877 4435 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2592 piperlongumine 83.33 µM -1.66526493618811 0.0603175118583499 no 3172 0.0479299553725952 4561 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_97 0535-0701 19.132 µM -1.66841860299067 0.0599683177325282 no 3173 0.0476163289375179 4486 2832013 YGL099W LSG1
SGTC_3145 9085516 49.47 µM -1.67423504471931 0.0593284389692581 no 3174 0.047042207300203 4567 25236195
SGTC_898 1000-0849 28.3 µM -1.67813676724248 0.058902210937209 no 3175 0.0466602012578518 4581 6751807
SGTC_2085 5307070 144.047 µM -1.68164799668366 0.058520698185819 no 3176 0.0463185588091466 4525 2840351
SGTC_2282 7944268 200 µM -1.68376839795173 0.0582912472426479 no 3177 0.0461132184279281 4562 2970414
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.68583743512566 0.0580680362536668 no 3178 0.0459135576121697 4580 641818 YHR062C RPP1
SGTC_3247 9135149 49.47 µM -1.69491088371681 0.0570970999613086 no 3179 0.0450461637727281 4614 8934436 YOR116C RPO31
SGTC_374 0880-0231 82.3 µM -1.69730933498552 0.0568425926568997 no 3180 0.0448190966500352 4451 6833587
SGTC_893 0958-0369 48.9 µM -1.6978131449506 0.0567892454951003 no 3181 0.0447715170761758 4453 6819948
SGTC_1044 1222-0021 1.78 µM -1.6994428396792 0.0566169512992243 no 3182 0.0446178879939063 4514 4306703
SGTC_892 0929-0076 29 µM -1.70412632917689 0.0561240964438641 no 3183 0.0441787443599069 4576 5751038
SGTC_526 4469-0568 170 µM -1.7056574397416 0.0559637098519579 no 3184 0.0440359390698329 4559 2901964
SGTC_2012 4023501 200 µM -1.71120142774784 0.0553859899183798 no 3185 0.0435219676109358 4569 3477460
SGTC_2544 sphondin 68.51 µM -1.71341401245222 0.0551567430032234 no 3186 0.043318200106995 4545 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2625 euphol 100 µM -1.71448090197869 0.0550464702720921 no 3187 0.0432202207978692 4581 6708538 A triterpene alcohol.
SGTC_2811 7967822 32.47 µM -1.72075543596641 0.0544014607687133 no 3188 0.0426476060919334 4602 2232244
SGTC_2034 5197015 53.07 µM -1.72482303174742 0.0539865242053883 no 3189 0.0422796848723384 4595 780676
SGTC_1077 5-fluorocytosine 377 nM -1.72726559848409 0.0537385637636903 no 3190 0.0420599872457027 4631 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2838 9002687 71.43 µM -1.73518896536829 0.0529404166371113 no 3191 0.0413536701743589 4588 6457060
SGTC_1053 3366-3204 134 µM -1.73549434978602 0.0529098434467226 no 3192 0.0413266407109242 4596 3632071 YPR165W RHO1
SGTC_2759 disulfiram 3.38 µM -1.73899078519915 0.0525607992609382 no 3193 0.0410181918999894 4513 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1112 tnp00069 1.16933 µM -1.74596302159243 0.0518702281091517 no 3194 0.0404086888067905 4587 145826
SGTC_2735 sertaconazole 140 nM -1.74812318251536 0.0516577422992718 no 3195 0.0402213497590273 4718 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_430 0958-0115 16.4 µM -1.75155832543755 0.0513212677730581 no 3196 0.0399248919356903 4536 6833180
SGTC_1503 4585-0012 61.3 µM -1.75199985205719 0.0512781466804062 no 3197 0.0398869166790129 4627 2922052
SGTC_3319 9138450 16.7555 µM -1.75304486766337 0.0511762015036948 no 3198 0.0397971529173795 4562 2029690
SGTC_1016 4226-1401 38 µM -1.75840678959684 0.0506556601185367 no 3199 0.0393391593548661 4619 2901613
SGTC_3328 9140624 29.0385 µM -1.76248598119672 0.0502624790960772 no 3200 0.038993611447435 4602 4904392
SGTC_1233 0325-0408 14.2 µM -1.7678478529874 0.0497493686470189 no 3201 0.0385431712655992 4626 12874
SGTC_1241 0364-0022 50.8 µM -1.77890089622936 0.0487048244890157 no 3202 0.0376280055817169 4626 4563895
SGTC_2630 antimycin a 100 µM -1.78326606826522 0.0482971630744304 no 3203 0.0372715010732845 4556 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2214 7179297 48.276 µM -1.78461185864534 0.048172032272985 no 3204 0.0371621482810668 4679 769744
SGTC_2231 micatex 6.853 µM -1.78750060907384 0.0479043139430615 no 3205 0.0369283068822015 4641 20737 An antifungal of unknown mechanism.
SGTC_1407 3909-7909 12.3 µM -1.79182796340476 0.0475055012154102 no 3206 0.0365802640051471 4646 4411780
SGTC_2287 7945887 168.79 µM -1.79278286373365 0.0474178559983058 no 3207 0.0365038253007093 4634 1245853
SGTC_2197 6588183 93.1375 µM -1.79357939271829 0.047344845997587 no 3208 0.0364401640693295 4651 884136
SGTC_706 4262-0057 46.9 µM -1.8023178602227 0.0465497778195812 no 3209 0.0357477050564758 4623 883298
SGTC_2153 5569715 200 µM -1.80931790583194 0.0459206398354064 no 3210 0.0352008143849021 4646 2054701
SGTC_1314 1222-0010 41.1 µM -1.81571730247063 0.0453514810403652 no 3211 0.0347068742511168 4637 3526027
SGTC_3159 9100096 49.47 µM -1.81623939267661 0.0453052980858695 no 3212 0.0346668288757718 4592 25236875
SGTC_1554 st069299 38.7 µM -1.81704600964311 0.0452340209019809 no 3213 0.0346050343306377 4587 24207999
SGTC_218 alverine citrate 93.75 µM -1.81728489862441 0.0452129286612425 no 3214 0.0345867505336154 4672 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_211 3455-0679 143.504 µM -1.8207556572516 0.044907376477379 no 3215 0.0343220037823449 4602 748649
SGTC_354 2783-3500 4.88 µM -1.82349216771471 0.0446676385395496 no 3216 0.0341144411267807 4614 6740761
SGTC_1308 1187-1617 41.4 µM -1.83233208491528 0.0439002340493242 no 3217 0.0334509798378823 4664 2882570
SGTC_838 0109-0203 71.4 µM -1.83309213608321 0.0438347525491408 no 3218 0.0333944351964047 4662 759422
SGTC_2471 5466956 24.79 µM -1.83454266141453 0.04371000256671 no 3219 0.0332867405779248 4649 724419
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.83483688437644 0.0436847333960972 no 3220 0.0332649308512564 4583 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3321 9137793 26.8275 µM -1.83951995994782 0.0432841148281463 no 3221 0.0329193724350266 4632 4904192
SGTC_2675 theaflavin digallate 100 µM -1.84397328398705 0.0429059076867758 no 3222 0.0325935168784893 4592 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_467 ro 31-8220 72.8 µM -1.85406954008681 0.0420583508406961 no 3223 0.0318646059071621 4628 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2769 toremifene 3.73 µM -1.86351024029189 0.0412781358545079 no 3224 0.0311952565801797 4636 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2116 5511452 16.8835 µM -1.86583382113997 0.0410879165554957 no 3225 0.0310323094364393 4649 870744
SGTC_2128 5255449 168.493 µM -1.86887870786181 0.0408397244871409 no 3226 0.030819845620412 4567 736008
SGTC_3331 9141060 1.957 µM -1.87375629210294 0.0404446832265338 no 3227 0.0304820116045048 4633 4906567 YPR165W RHO1
SGTC_2930 9013230 14.89 µM -1.87951274396215 0.0399824589335059 no 3228 0.0300872575363801 4600 2995857
SGTC_2080 5212524 12.4 µM -1.88431583916804 0.0396000795980998 no 3229 0.0297611330941645 4615 260183
SGTC_1262 0737-0114 49.6 µM -1.89265368653313 0.0389433610000962 no 3230 0.0292019696018489 4668 765919
SGTC_769 0302-0231 76 µM -1.89583546489453 0.0386951023691121 no 3231 0.0289909023409249 4593 571869 YER009W NTF2
SGTC_1050 3232-1156 69.3 µM -1.89978503771934 0.0383887317030107 no 3232 0.0287306676219022 4628 700529
SGTC_1300 1094-0077 113 µM -1.90113106960541 0.0382847721203059 no 3233 0.0286424234673259 4649 5532636
SGTC_2225 6654152 15.4 µM -1.90163404609327 0.0382459841383407 no 3234 0.0286095068668619 4626 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1230 0170-0365 3.77 µM -1.90608063050849 0.0379044694515715 no 3235 0.0283198726574083 4661 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1634 st006576 41 µM -1.91001168566489 0.0376046255157288 no 3236 0.0280658543723561 4626 3915356
SGTC_429 1112-0049 25.5 µM -1.91105628633468 0.0375252743851271 no 3237 0.0279986739756926 4617 2836170
SGTC_745 0469-0705 296 µM -1.92254464920457 0.0366615712895523 no 3238 0.0272686305399434 4689 3486736
SGTC_919 tnp00227 403.569 nM -1.93940448530151 0.0354235438601461 no 3239 0.0262260524007675 4623 1269246 A methoxyflavone. YNL221C POP1
SGTC_2798 7813637 45.45 µM -1.94298322211215 0.0351652158405596 no 3240 0.0260090927649589 4658 956368
SGTC_3219 9131112 49.47 µM -1.95644558670023 0.0342072546055428 no 3241 0.0252063432292059 4554 17612988 YMR079W SEC14
SGTC_855 0428-0020 25 µM -1.96038483486849 0.0339310358375877 no 3242 0.0249754135153961 4687 6812414
SGTC_1331 1472-0049 76.2 µM -1.96172632860524 0.0338373905224462 no 3243 0.0248971774149264 4667 24051409
SGTC_396 dithiazanine 1.25 µM -1.96638580047001 0.0335137783339607 no 3244 0.0246270312061644 4653 10578 An antihelmenthic.
SGTC_2636 apigenin dimethyl ether 100 µM -1.96843133977402 0.0333725173749112 no 3245 0.0245092144529626 4626 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1693 xanthone 101.9 µM -1.97519017559407 0.0329092477940017 no 3246 0.0241232852000429 4711 7020 An insecticide.
SGTC_2968 9090663 33.37 µM -1.9785916387678 0.0326781146108086 no 3247 0.0239310009007087 4630 25236811
SGTC_2310 7668677 200 µM -1.98421653066368 0.0322988351188811 no 3248 0.0236158532507544 4629 2197143
SGTC_147 4466-0538 29.23 µM -1.99295857791026 0.0317165859102325 no 3249 0.0231329915281129 4669 6742687 YHR072W ERG7
SGTC_3189 9110682 49.47 µM -2.0012218241017 0.0311742261904474 no 3250 0.0226842450354271 4661 17122418
SGTC_3259 9138485 49.47 µM -2.00467658351273 0.0309497579109239 no 3251 0.0224988167312707 4653 17646153
SGTC_686 1319-0111 510 µM -2.01133299889067 0.0305210375433441 no 3252 0.022145147595686 4687 4562600
SGTC_977 1348-1378 135 µM -2.01633799835529 0.0302019300071716 no 3253 0.0218823220380847 4664 X977
SGTC_1449 4112-4002 201 µM -2.01650620225126 0.0301912539193144 no 3254 0.0218735351612725 4702 2059539
SGTC_692 k241-0027 77.8 µM -2.02925814312731 0.0293909353673763 no 3255 0.0212160021046689 4707 3600480
SGTC_116 0155-0182 31.788 µM -2.03045853285185 0.0293165139635348 no 3256 0.0211549760577636 4569 771486
SGTC_1690 st023502 41.2 µM -2.03429972758372 0.0290794196219968 no 3257 0.0209606923208019 4715 24207482
SGTC_1676 st018489 23.4 µM -2.04518767927616 0.0284160147689409 no 3258 0.0204181793481559 4651 3696235
SGTC_2280 7785178 200 µM -2.05526914670906 0.027813024715193 no 3259 0.019926507819098 4687 2954328
SGTC_2944 9067346 25.62 µM -2.06465797548609 0.0272610867650274 no 3260 0.0194776867598082 4615 6473075
SGTC_748 act1.228 77.9 µM -2.06483385915813 0.0272508349704811 no 3261 0.0194693614817004 4692 4421505 YNR035C ARC35
SGTC_62 0180-0423 3.232 µM -2.06799274986861 0.0270672584708282 no 3262 0.019320352429394 4664 30102 YGL099W LSG1
SGTC_1035 k081-0041 55.2 µM -2.07457179202775 0.0266882342731995 no 3263 0.0190131193355368 4686 731709
SGTC_2529 gangaleoidin 93.61 µM -2.07800204785125 0.0264923790072418 no 3264 0.0188545852652644 4678 4565183
SGTC_1130 3454-2858 15.9 µM -2.07874483975248 0.0264501268290237 no 3265 0.018820404625892 4658 715628 YIL048W NEO1
SGTC_1587 estradiol valerate 56.1 µM -2.09619472629481 0.0254736124656365 no 3266 0.0180324602941497 4733 13791 A steroid.
SGTC_1008 4106-0037 6 µM -2.09923075576895 0.0253068351329769 no 3267 0.0178982820297084 4726 2905394
SGTC_1978 st071761 42 µM -2.10560556893093 0.0249596250719715 no 3268 0.017619314259835 4721 5147680
SGTC_1950 st077106 7.18 µM -2.1163182942554 0.0243851449552519 no 3269 0.0171588729257972 4645 13831864
SGTC_1486 3970-0793 4.53 µM -2.11993834886503 0.024193542905948 no 3270 0.0170056224058737 4743 2844330
SGTC_2404 5161160 200 µM -2.14892642726835 0.0227044010542266 no 3271 0.0158201162693433 4686 2831543
SGTC_3165 9101544 49.47 µM -2.15253264425252 0.022524667027009 no 3272 0.0156777135296152 4719 5002184
SGTC_1692 fluoroquinolonic acid 71 µM -2.15401078503323 0.0224513438452396 no 3273 0.0156196630710786 4727 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1442 4112-3290 3 µM -2.1556463187948 0.022370447867744 no 3274 0.0155556464138608 4751 704353
SGTC_2363 9053361 176 µM -2.15766472127542 0.022270953686106 no 3275 0.0154769543588992 4698 6469797 YMR079W SEC14
SGTC_423 5-fluorouracil 457 µM -2.15969243452105 0.0221713767310057 no 3276 0.01539824363182 4660 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3056 9094900 49.47 µM -2.16040971698705 0.0221362424980142 no 3277 0.0153704829432746 4691 25236784
SGTC_1247 0448-0043 5.84 µM -2.20335760626942 0.0201165258937789 no 3278 0.0137847768554107 4696 3089013 YGL099W LSG1
SGTC_3266 9136860 49.47 µM -2.2064756263565 0.0199761844484458 no 3279 0.0136753574909302 4502 4871271 YPR165W RHO1
SGTC_1731 st035964 63 µM -2.20860397823965 0.0198808655117038 no 3280 0.0136010992022211 4632 6739575
SGTC_2149 5554786 194.827 µM -2.2251437789539 0.0191531968095873 no 3281 0.0130357938064368 4741 745063 YPR165W RHO1
SGTC_431 k089-0097 107 µM -2.23191280888992 0.018861990320782 no 3282 0.0128103630764319 4452 5499420
SGTC_1763 st044482 94.5 µM -2.23459105387316 0.0187478155978293 no 3283 0.0127221043507054 4724 88505
SGTC_1452 4194-0072 190 µM -2.26142610673798 0.0176359382673808 no 3284 0.0118664418260452 4744 1343545
SGTC_1015 4130-4525 82 µM -2.26587915691532 0.0174569858230644 no 3285 0.0117293915510925 4731 1363237
SGTC_1476 4112-3294 3.34 µM -2.26784100965465 0.0173786392068929 no 3286 0.0116694494333195 4727 704369
SGTC_1968 st069590 43.6 µM -2.27223824533199 0.0172041257250944 no 3287 0.0115360622269162 4717 6384066
SGTC_2013 4024628 200 µM -2.2747041828965 0.0171069167269248 no 3288 0.0114618407015648 4722 5230760
SGTC_1404 3909-7820 48.3 µM -2.28249892818638 0.0168027235931756 no 3289 0.0112299503448433 4738 23741373
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -2.2831546812823 0.0167773448590651 no 3290 0.0112106292639907 4714 551469
SGTC_398 bronopol 33.3 µM -2.28339584462918 0.0167680196870291 no 3291 0.0112035309094273 4689 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_689 0833-0039 98 µM -2.28792359907142 0.0165937642434002 no 3292 0.0110709853699549 4694 5374726
SGTC_1745 st081495 74 µM -2.29317753538849 0.0163935056346718 no 3293 0.010918892967066 4633 13842402 YBL026W LSM2
SGTC_2849 9019321 12.99 µM -2.29617290579128 0.016280263245635 no 3294 0.010832998531052 4725 16489627
SGTC_690 glyoxal 20.3 µM -2.30090348241536 0.0161027847653376 no 3295 0.010698543617493 4578 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1937 st074714 47.2 µM -2.32074851113572 0.0153762065420616 no 3296 0.0101502104356087 4709 17250970
SGTC_758 0868-0029 16 µM -2.33418003379442 0.0149005741773954 no 3297 0.00979314846287432 4663 762687
SGTC_1553 gossypol 38.6 µM -2.34340972570838 0.0145811168204591 no 3298 0.00955419291653622 4737 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_768 0384-0033 77.3 µM -2.35731239380154 0.0141110500018647 no 3299 0.00920387698949329 4727 3965305 YMR134W ERG29
SGTC_3333 9141820 12.094 µM -2.35902585015741 0.0140540297682864 no 3300 0.00916148967669292 4720 1939433
SGTC_2138 5575593 77.673 µM -2.37426621089852 0.013555542224983 no 3301 0.00879193386463108 4766 762213
SGTC_1640 st009078 66.4 µM -2.38332232590429 0.0132666194897849 no 3302 0.00857858220246299 4759 690618
SGTC_1458 k015-0034 6.33 µM -2.41336462545085 0.0123459326481292 no 3303 0.0079029991529586 4761 3598957
SGTC_157 1348-1695 65.819 µM -2.42114395610561 0.0121167441993945 no 3304 0.00773587447553255 4705 5380510
SGTC_1786 berberine 21.6 µM -2.42656035113444 0.0119593569083655 no 3305 0.0076213574457109 4678 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_875 0709-0210 25.7 µM -2.43644076004164 0.0116768198305451 no 3306 0.00741629938770849 4743 6251364
SGTC_3151 9099821 49.47 µM -2.45718184996025 0.0111025062452512 no 3307 0.00700158912995791 4719 17174189
SGTC_1244 0416-0015 52.5 µM -2.46197969228988 0.0109732088838255 no 3308 0.00690862449920664 4745 96201
SGTC_2756 carbadox 75.1 µM -2.46258897348968 0.0109568834396624 no 3309 0.00689689720012926 4688 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3324 9138759 60.749 µM -2.46571371660878 0.0108734889000846 no 3310 0.00683702873178852 4741 45595710
SGTC_2341 7987486 176.74 µM -2.50044154828806 0.00998320997431873 no 3311 0.00620193000513456 4759 1258686
SGTC_2244 6635614 200 µM -2.50269110399872 0.00992780039378998 no 3312 0.00616265322346163 4745 836499
SGTC_1896 st058441 89 µM -2.51115139406281 0.00972180879679911 no 3313 0.00601690379679847 4770 688759
SGTC_480 am 92016 50 µM -2.51457607165535 0.00963949226687489 no 3314 0.00595877945112356 4765 2129 K+ channel blocker.
SGTC_2507 purpurin 79.67 µM -2.53373848880226 0.00919004639135558 no 3315 0.00564264586752893 4745 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1718 roemerine 11.9335 µM -2.53703464251695 0.00911461404148401 no 3316 0.00558979453464607 4470 235224 An aporphine alkaloid with mutagenic activity.
SGTC_601 0986-0029 62.9 µM -2.55972703270349 0.00860985767081029 no 3317 0.00523772038289456 4735 24747981
SGTC_1060 3448-7350 82 µM -2.5640073102796 0.00851744807230534 no 3318 0.00517356826199792 4748 570178
SGTC_716 1683-5115 658 µM -2.60115948078361 0.00775123261002378 no 3319 0.00464546255074249 4759 723597
SGTC_2117 5521686 200 µM -2.61132201972739 0.00755250344900708 no 3320 0.00450964607183074 4775 803312
SGTC_2722 naftopidil 47.16 µM -2.61953518244534 0.00739518730488178 no 3321 0.00440248448480977 4743 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2156 5649887 115 µM -2.66865687294153 0.00651321291774517 no 3322 0.00380776029808049 4783 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_73 0327-0325 16.231 µM -2.69031246915097 0.00615488092829535 no 3323 0.00356925718894208 4666 53298
SGTC_1191 1487-1166 10.6 µM -2.70317328100108 0.00595044038633886 no 3324 0.00343404656335588 4773 3955771
SGTC_1775 st081588 35.1725 µM -2.70820246177965 0.00587214683131924 no 3325 0.00338243699533722 4764 1426443 YGL099W LSG1
SGTC_1406 3909-7906 11.9 µM -2.80442414743951 0.00454024396524438 no 3326 0.0025203273275724 4786 X1406
SGTC_1638 st008370 60.6 µM -2.80681751881144 0.00451086717264258 no 3327 0.00250167879903765 4757 24207134
SGTC_417 st075190 100 µM -2.84662691837084 0.00404651249496494 no 3328 0.00220925560112448 4790 222757
SGTC_178 4092-0806 87.505 µM -2.86000360132452 0.00390037098241572 no 3329 0.00211818098611616 4711 2169044
SGTC_2104 5389443 200 µM -2.86079629104848 0.00389186107310711 no 3330 0.00211289240703454 4785 2244536
SGTC_2736 butenafine 14.65 µM -2.86835531853607 0.00381154314968539 no 3331 0.00206305931942995 4762 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_788 1182-0090 188 µM -2.89438298635352 0.00354623094805051 no 3332 0.00189952238366623 4766 5715185
SGTC_1785 bathophenanthroline 24 µM -2.92586068099677 0.00324759000413139 no 3333 0.00171752365405146 4752 72812 An iron chelator.
SGTC_2718 lomofungin 53.02 µM -2.92657384915749 0.00324109415420023 no 3334 0.00171359064368975 4783 5351222 A RNA synthesis inhibitor.
SGTC_734 2023-0417 80 µM -2.95994984575622 0.00294985993479893 no 3335 0.0015384456454111 4786 3935732
SGTC_117 lucigenin 22.078 µM -2.9715166772266 0.00285457158803037 no 3336 0.00148166389605919 4761 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2526 patulin 37.61 µM -2.98230775997697 0.00276818639121395 no 3337 0.00143042126442382 4780 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3329 9141233 27.5565 µM -2.9962029008021 0.00266042944301402 no 3338 0.00136682237121107 4781 4909101 YNL103W MET4
SGTC_1766 st045414 44.774 µM -3.02019063732869 0.00248328625005861 no 3339 0.00126307814174137 4789 253960
SGTC_1715 st032160 10.2275 µM -3.02563926776008 0.00244456669862673 no 3340 0.00124054057190351 4740 5289825
SGTC_2016 5121758 140 µM -3.04267857671412 0.00232697925380425 no 3341 0.00117241321843626 4757 2795203
SGTC_1128 3448-9350 235 µM -3.06312601558168 0.00219264617749654 no 3342 0.0010951890011232 4766 619386
SGTC_2969 9091408 28.7 µM -3.0632794359365 0.00219166538748247 no 3343 0.00109462762403247 4765 4286311
SGTC_1707 st032323 6.317 µM -3.06875322848979 0.00215693151296487 no 3344 0.00107477034043647 4707 3132057 YMR211W DML1
SGTC_1000 4048-0884 8.67 µM -3.08209369079146 0.00207436069275642 no 3345 0.00102775065128531 4785 13040088
SGTC_978 1416-0512 87.4 µM -3.18124330756826 0.00154511856117931 no 3346 0.000733222068829359 4796 6814003
SGTC_1572 epiandrosterone 68.9 µM -3.20853785577278 0.00142281432152279 no 3347 0.000667058724775642 4795 441302 A steroid.
SGTC_2243 6634756 200 µM -3.27019297954174 0.00117841168818398 no 3348 0.000537370688333247 4791 885676
SGTC_1679 SEC14.276 6.7 µM -3.27101243240544 0.00117543945381554 no 3349 0.000535815996129841 4776 1005053 YMR079W SEC14
SGTC_1951 sophoraflavanone G 9.2 µM -3.31396990086538 0.00102891034957768 no 3350 0.000459907040737219 4766 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1672 st016598 6.51 µM -3.38730957307185 0.000816907261229831 yes 3351 0.000352908480985302 4786 4665860 YNL267W PIK1
SGTC_172 1112-0046 2.638 µM -3.449725101123 0.000668982460406113 yes 3352 0.00028057883456501 4797 2802135 YIL048W NEO1
SGTC_2068 5226020 147 µM -3.63874133692615 0.000358393753451116 yes 3353 0.000136986903778722 4800 1810509
SGTC_1880 MG-132 525 µM -3.76535928198387 0.000232149184198609 yes 3354 8.31548833728128e-05 4797 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2284 7945075 39.21 µM -4.02545412259543 9.1330684378156e-05 yes 3355 2.84327333443487e-05 4799 1245402
SGTC_1522 st012842 45.6 µM -4.4282565868807 1.93106150904099e-05 yes 3356 4.74989243605576e-06 4798 3491067 YOR116C RPO31