SGTCid condition conc unit YHL037C|YHL037C.score YHL037C|YHL037C.strain.pval YHL037C|YHL037C.strain.significant YHL037C|YHL037C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2067 5224629 34.075 µM 5.47636385597836 4.26880563734887e-09 yes 1 2.17077257689818e-08 6 2835000
SGTC_3233 9132340 49.47 µM 4.67547213359061 4.37950101194017e-07 yes 2 1.46639050649917e-06 10 17682950
SGTC_305 1682-2595 20.8 µM 4.4337981839001 1.54892994814766e-06 yes 3 4.62936507948456e-06 16 226033
SGTC_789 1309-1135 70.6 µM 4.24480663519412 3.9840205075284e-06 yes 4 1.09391000829587e-05 23 3092424
SGTC_829 1635-0120 117 µM 4.19597661810152 5.0543219672834e-06 yes 5 1.35849138825032e-05 36 285054
SGTC_3204 9114183 49.47 µM 4.02283239289954 1.15157549026546e-05 yes 6 2.87512090472027e-05 31 17027248
SGTC_2993 9054257 71.4286 µM 3.77460523575014 3.54902869862796e-05 yes 7 8.0130622512655e-05 51 6470217 YGL055W OLE1
SGTC_2916 7875993 68.79 µM 3.69393107483815 5.04582659477779e-05 yes 8 0.000110406838995862 36 1299250
SGTC_2585 alliin 100 µM 3.65389572440315 5.99341207552696e-05 yes 9 0.000129145600326285 37 87310 A garlic compound which reacts with lipids.
SGTC_2074 5212007 75.395 µM 3.64703269476697 6.17182541927378e-05 yes 10 0.00013264308989552 18 758611
SGTC_3082 9117008 49.47 µM 3.48914167473355 0.000119564536886637 yes 11 0.000242287124048641 29 41448529
SGTC_622 1348-1566 26.3 µM 3.43023522096175 0.000152004973408186 yes 12 0.000301529110379683 34 7340407
SGTC_1651 st011928 86.1 µM 3.38777392705053 0.0001803166393772 yes 13 0.000352311584067101 26 720198
SGTC_1707 st032323 6.317 µM 3.35184151559291 0.000208052407926771 yes 14 0.000401379796760638 86 3132057 YMR211W DML1
SGTC_2069 5228469 200 µM 3.33781190226678 0.000219925600930053 yes 15 0.000422204454932867 33 2835210
SGTC_2229 7354935 190 µM 3.30948220772511 0.00024585341292309 yes 16 0.00046734353229697 17 318112
SGTC_1429 4049-0205 9.46 µM 3.21115524437242 0.000359636175592777 yes 17 0.000661012469807532 31 22774478
SGTC_3114 9122766 49.47 µM 3.2074725277908 0.000364725258681904 yes 18 0.000669534246684244 48 17176985
SGTC_1939 st074455 53.6 µM 3.19723640121191 0.000379223902337024 yes 19 0.000693755812283388 60 1644229
SGTC_2286 7945697 125 µM 3.17148997158266 0.000418090874070045 yes 20 0.000758295521816102 97 1245733
SGTC_1231 0242-0792 125 µM 3.15377701789338 0.000446941897942406 yes 21 0.000805860908870222 50 3707635
SGTC_2806 7952793 58.44 µM 3.09353389404509 0.000559452759305671 yes 22 0.000988939794141471 60 2972490
SGTC_1720 st037298 9.481 µM 3.06178858355427 0.000628773659572114 yes 23 0.00110009395844625 81 597396
SGTC_745 0469-0705 296 µM 3.03132579867056 0.000702671162254506 yes 24 0.00121741185712981 58 3486736
SGTC_2522 biochanin a 4.94 µM 3.01121968627193 0.000755746721976925 yes 25 0.00130100262021799 39 5280373 A possible chelator.
SGTC_354 2783-3500 4.88 µM 2.96771330247358 0.000883462977034978 yes 26 0.00150012015645669 108 6740761
SGTC_1680 diphenhydramine 100 µM 2.96311690771096 0.000898055802050116 yes 27 0.00152270440017703 81 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_563 tetrahydrosecaminediol 614 µM 2.93673700985437 0.000986179424381694 yes 28 0.00165842628118923 58 334274 A psychoactive constituent of the cannabis plant.
SGTC_1702 st027038 51 µM 2.92812112293448 0.0010166378397945 no 29 0.00170508584651682 53 5521182
SGTC_1945 st075991 56.6 µM 2.92373842968451 0.00103246031580818 no 30 0.00172927619430468 69 1084980
SGTC_2825 7998094 58.44 µM 2.89656756121678 0.00113570057041524 no 31 0.00188634699067541 76 2987815
SGTC_1873 rapamycin 2 nM 2.81190712502995 0.00152099246158231 no 32 0.00246243606445142 146 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_444 curcumin 90.4 µM 2.78085890364424 0.00168987992804784 no 33 0.00271076474272493 76 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1681 tripelennamine 100 µM 2.78044086697811 0.00169226601007472 no 34 0.00271425726353341 62 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3198 9112019 49.47 µM 2.74072161004751 0.00193347601387903 no 35 0.00306522125446442 75 45595555
SGTC_1876 myriocin 605 nM 2.73278968409782 0.00198523469133165 no 36 0.00314002095621536 91 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3180 9109287 49.47 µM 2.7113534566024 0.00213146890078482 no 37 0.00335045768008301 77 18891271
SGTC_1389 3405-0187 19 µM 2.70215103470506 0.00219719083940888 no 38 0.00344462299512263 75 799890
SGTC_2964 9083345 53.42 µM 2.66062757014786 0.00251717765688858 no 39 0.00389975874974233 91 17741579
SGTC_2335 9018011 154.17 µM 2.64513147151757 0.00264700298256392 no 40 0.00408295913760196 106 6458208
SGTC_1377 2944-0135 198 µM 2.63788944655766 0.00270972513013647 no 41 0.00417118868520273 130 1894137
SGTC_2089 5281248 129.67 µM 2.61983411997659 0.00287198297781488 no 42 0.00439862735907152 106 2737878
SGTC_3232 9132874 49.47 µM 2.61655293250457 0.00290239376244995 no 43 0.00444112956984833 83 3784940
SGTC_744 1594-0068 283 µM 2.59566225539813 0.00310291611137011 no 44 0.00472044079222697 131 668392
SGTC_602 3130-1533 38.1 µM 2.55750938914593 0.00350157217670397 no 45 0.0052712355967031 115 720941
SGTC_1366 1683-0113 21.9 µM 2.53916093590787 0.00370920178029963 no 46 0.00555593475567681 87 708623
SGTC_1047 2043-3044 82 µM 2.49584391836083 0.00424381088755596 no 47 0.00628289393466475 140 669592
SGTC_1919 st067113 52.3 µM 2.4779376403118 0.0044842365085237 no 48 0.00660721193444338 139 1268243
SGTC_1713 st033146 12.748 µM 2.46483776030803 0.00466775688156076 no 49 0.00685376512530072 148 674619
SGTC_766 1391-0721 126 µM 2.44856589606162 0.00490502804611255 no 50 0.00717130959039571 121 1020919 YIL115C NUP159
SGTC_2986 9022445 71.43 µM 2.44535473305341 0.00495310235881745 no 51 0.00723548657669457 129 6459286
SGTC_2936 9038235 15.59 µM 2.42552693161156 0.00525935177830935 no 52 0.00764309076027926 143 4749415
SGTC_976 1348-1067 47.6 µM 2.4251408205083 0.00526547906368449 no 53 0.00765122485499852 147 5310671 YGL099W LSG1
SGTC_2517 totarol 10 µM 2.42096401695845 0.0053321687076721 no 54 0.00773970472138698 114 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2394 5221648 200 µM 2.40932936173198 0.0055219123703637 no 55 0.00799093385422867 148 788586
SGTC_1309 pyrazolanthrone 13.4 µM 2.40189885781478 0.00564620932562091 no 56 0.0081551086706796 125 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2873 9040596 71.43 µM 2.39819050037044 0.00570916687050719 no 57 0.00823814691559206 157 6463863
SGTC_2588 indole-3-carbinol 100 µM 2.38335919411683 0.00596723498794216 no 58 0.00857772299544847 185 3712 Induces cell cycle arrest.
SGTC_546 peri-Naphthalide 147 µM 2.3782018225643 0.00605936841254246 no 59 0.00869865048009666 121 223824 A penicillin ester.
SGTC_2127 5253358 187.912 µM 2.37297936260019 0.0061539471049224 no 60 0.00882262489826786 131 20612
SGTC_2246 7293507 91.5585 µM 2.37232659307727 0.00616586022934447 no 61 0.00883822916816595 149 887656
SGTC_1978 st071761 42 µM 2.37071315824658 0.00619539330661671 no 62 0.0088769016904235 91 5147680
SGTC_1540 guanosine 70.6 µM 2.35614704965358 0.00646774089090923 no 63 0.00923280313752398 92 6802 Guanosine is a purine nucleoside
SGTC_822 1487-0950 154 µM 2.3289418243558 0.0070048907511808 no 64 0.00993107391874138 131 1958375
SGTC_1149 3909-7961 23.3 µM 2.32742909783832 0.00703588204324413 no 65 0.00997121928648391 157 735261
SGTC_1259 0671-0132 43 µM 2.32599524574046 0.00706536907723014 no 66 0.0100094021553484 162 X1259
SGTC_3283 9109332 35.8195 µM 2.32326440678524 0.0071218302847295 no 67 0.0100824763340057 109 17027281
SGTC_2048 5246248 200 µM 2.30348529130408 0.00754278868155683 no 68 0.0106257768969301 94 677046
SGTC_1419 3993-2473 62.6 µM 2.29336224582474 0.00776659891341642 no 69 0.0109135791657031 142 704026
SGTC_2196 6573537 42.6665 µM 2.28913335114406 0.00786181275829814 no 70 0.0110358027871509 97 2903087
SGTC_959 1222-0044 107 µM 2.28798925928969 0.00788774789329327 no 71 0.0110690733076644 153 6083612
SGTC_2172 5754775 163.918 µM 2.27949523123774 0.00808266139438592 no 72 0.01131882156285 163 2263357
SGTC_1766 st045414 44.774 µM 2.27894074260581 0.0080955312568673 no 73 0.0113352940329669 186 253960
SGTC_3203 9113543 49.47 µM 2.2748409048096 0.00819124998946988 no 74 0.0114577377137713 166 17018012
SGTC_1661 st013063 9.66 µM 2.25102207724416 0.0087672579349991 no 75 0.0121920695573684 187 721395
SGTC_2331 7980721 200 µM 2.24306183436134 0.00896752321792927 no 76 0.0124464136824576 166 2981221
SGTC_152 4469-0003 551.229 µM 2.23608885477892 0.00914623196581358 no 77 0.0126729756827466 140 697280
SGTC_1874 staurosporine 7.6 µM 2.23218956241605 0.00924751900995213 no 78 0.0128012184855456 185 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2816 7982706 58.44 µM 2.22393879101195 0.00946508011035318 no 79 0.013076281358912 202 2981853
SGTC_2397 5161689 200 µM 2.21291069853264 0.00976285723455467 no 80 0.0134519014820914 185 2259942
SGTC_229 benomyl 22.8748 µM 2.19953325061147 0.0101350293752581 no 81 0.0139200137614758 176 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_561 1550-0330 72.9 µM 2.19570992275302 0.0102436467798261 no 82 0.0140563562433911 132 6812934
SGTC_293 4049-0273 38.5 µM 2.19262865453152 0.0103319203218453 no 83 0.0141670724348767 128 1380311
SGTC_1107 amlodipine 47 µM 2.17695081069897 0.0107914126735701 no 84 0.0147421188709832 200 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1351 1496-0003 46.5 µM 2.16496148198261 0.0111547073381586 no 85 0.015195317575235 161 3891978
SGTC_347 4534-1311 26.2 µM 2.15760168021595 0.0113829494530722 no 86 0.0154794069797912 159 2862016
SGTC_1450 4112-4260 37.6 µM 2.15492649840322 0.011466912005863 no 87 0.0155837932095628 186 1633175
SGTC_3026 9090633 49.47 µM 2.15332097787389 0.0115175603411767 no 88 0.0156467306118846 175 25236842
SGTC_1522 st012842 45.6 µM 2.14859474400252 0.0116677852435858 no 89 0.0158332693493355 186 3491067 YOR116C RPO31
SGTC_1671 st016596 74.5 µM 2.12671303381085 0.0123856763953128 no 90 0.0167219669486933 184 2829167
SGTC_2789 5281112 71.43 µM 2.12471447271202 0.0124531123956974 no 91 0.0168052225427115 230 765948
SGTC_2452 5863136 48.41 µM 2.10256897347208 0.013221888700314 no 92 0.0177517322369491 180 2184096
SGTC_2888 9058547 12.99 µM 2.08977277368627 0.0136845352191256 no 93 0.0183191080934905 132 16476514
SGTC_1995 st072814 61.1 µM 2.08767552166154 0.0137616784943521 no 94 0.0184135571880735 185 5769371
SGTC_2448 5185112 27.17 µM 2.07813114460608 0.0141175056134235 no 95 0.0188486409030663 165 5718189
SGTC_615 k087-0205 167 µM 2.07364823427337 0.0142873527382778 no 96 0.0190559960437796 177 9642773
SGTC_435 c-PAF 6.7 µM 2.06943709693646 0.0144485032376902 no 97 0.0192525441924121 235 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1886 st057356 49.9 µM 2.06813148326638 0.0144987827835983 no 98 0.0193138304683772 189 24207747
SGTC_1470 k295-0292 231 µM 2.06236512001578 0.0147226524888623 no 99 0.0195864937387084 200 5045612
SGTC_2387 9077560 195.08 µM 2.06191805422351 0.0147401326345124 no 100 0.0196077691775483 196 5303272
SGTC_2955 9076254 12.21 µM 2.0594676814589 0.0148362589199704 no 101 0.0197247289642127 173 16459619
SGTC_2221 6807166 181.081 µM 2.05253359625248 0.0151112042364977 no 102 0.02005891673831 106 674925
SGTC_3083 9117465 49.47 µM 2.0462359590682 0.0153646962026716 no 103 0.0203665805182773 235 16420915
SGTC_3170 9103054 49.47 µM 2.03647527470866 0.0157647954984312 no 104 0.0208513267194753 187 16432970
SGTC_876 0720-0963 56.8 µM 2.03452253104726 0.0158459041112668 no 105 0.0209494696354777 196 765861
SGTC_1455 4262-0120 131 µM 2.03127206552029 0.0159817081452197 no 106 0.0211137017299145 227 1529587
SGTC_2797 7859098 81.82 µM 2.01339468091767 0.0167465882696955 no 107 0.0220365623714595 229 972681
SGTC_3044 9093193 49.47 µM 2.01085635765399 0.0168576889496924 no 108 0.0221703156291682 253 25236277
SGTC_1999 st074831 12.5 µM 2.00786362436739 0.0169894879851691 no 109 0.0223288927759053 238 17112523
SGTC_780 0109-0199 192 µM 2.00741954848764 0.0170091198088304 no 110 0.0223525045282804 252 610414
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.00193992475199 0.0172529648244954 no 111 0.0226455965234775 296 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1367 1812-0510 76.9 µM 1.99791474365587 0.0174339837613248 no 112 0.022862951967085 237 1142582 YDR527W RBA50
SGTC_1436 4092-1007 8.32 µM 1.99101843208655 0.0177478920591875 no 113 0.0232394304424583 206 2881121
SGTC_1509 1326-1131 80 µM 1.98982124427405 0.0178028743567446 no 114 0.0233053151707151 184 768313
SGTC_1835 st008666 49.2 µM 1.97850496466863 0.0183298044237374 no 115 0.0239358845359792 177 690455
SGTC_423 5-fluorouracil 457 µM 1.97500874662163 0.0184952650674759 no 116 0.0241335777133842 233 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2049 5262831 67.185 µM 1.97492957167387 0.0184990267495507 no 117 0.024138070485057 243 763417
SGTC_298 1391-0729 10 µM 1.9562919843016 0.0194028335522363 no 118 0.0252153839553224 195 3237558
SGTC_337 1315-0038 354 µM 1.94861103705191 0.0197860830874984 no 119 0.0256709465317779 222 1626437
SGTC_644 1498-1197 63.3 µM 1.94679631755307 0.0198775631269902 no 120 0.0257795793148106 265 6741615
SGTC_1249 0481-0015 10.2 µM 1.94555472957613 0.0199403581726866 no 121 0.0258541247291004 217 4227577
SGTC_948 3448-0295 75.3 µM 1.9310136106825 0.0206884101154582 no 122 0.0267406846309181 269 678569
SGTC_266 formosanin C 406 nM 1.92440841873527 0.0210359785484385 no 123 0.0271517050125125 292 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_529 4076-0302 30.3 µM 1.92335362076033 0.0210919375207545 no 124 0.0272178273773116 236 5816522
SGTC_1204 4049-0315 18.3 µM 1.92013235742361 0.0212636116827908 no 125 0.027420591526167 257 588402
SGTC_896 0964-0007 44.5 µM 1.90715693485173 0.0219671392587614 no 126 0.0282501341561667 201 6756758
SGTC_1694 st024011 44.9 µM 1.90318513631238 0.0221863800358865 no 127 0.02850819597434 272 2787533
SGTC_232 clozapine 119 µM 1.90308865378295 0.0221917286998007 no 128 0.0285144891033 281 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3175 9106517 49.47 µM 1.89679691637802 0.0225428779308446 no 129 0.0289273732374135 217 41468073
SGTC_2948 9070189 9.45 µM 1.89224881081009 0.0227996204321108 no 130 0.0292289188603596 239 6473636 YDL196W YDL196W
SGTC_594 1487-1584 10.8 µM 1.88755553827634 0.0230671364027392 no 131 0.0295428218848217 255 5013332
SGTC_2075 5212009 200 µM 1.88613220458775 0.0231487867669741 no 132 0.0296385707573162 203 780898
SGTC_2278 7948257 134.34 µM 1.86888945522949 0.0241574057830464 no 133 0.0308190978367251 246 1247028
SGTC_2586 curcumin 80 µM 1.86496631647249 0.0243919752115018 no 134 0.0310930628777915 347 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_370 0180-0345 38.7 µM 1.85897159392526 0.0247540987995877 no 135 0.0315155824418983 226 3989527
SGTC_1910 st062352 60.4 µM 1.85822091204648 0.024799761405363 no 136 0.0315688247568387 308 2245730
SGTC_833 3852-0053 558 µM 1.85241214991896 0.0251554916898916 no 137 0.0319833309656145 286 3123681
SGTC_1105 epirubicin 18.1 µM 1.84857047821167 0.0253930983857956 no 138 0.0322599294105559 255 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3058 9093861 49.47 µM 1.84449542075873 0.0256471917445981 no 139 0.0325554862864648 275 17217477
SGTC_3354 9151612 71.43 µM 1.82812571554685 0.0266894435974795 no 140 0.0337653431799525 272 27261949
SGTC_133 0724-0033 378.92 µM 1.8275621691667 0.0267259451684296 no 141 0.0338076439121834 249 280309
SGTC_682 0kpi-0099 17 µM 1.82665235906822 0.0267849626350488 no 142 0.0338760277812798 329 1714895 YML126C ERG13
SGTC_3315 9136395 68.55 µM 1.82444478491033 0.0269286158363971 no 143 0.0340424283043164 270 16876844
SGTC_2765 myclobutanil 7.74 µM 1.81977211110397 0.0272348022384642 no 144 0.0343968582513011 299 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3153 9100258 49.47 µM 1.81356581569893 0.0276459677225123 no 145 0.0348722986554231 297 25236848
SGTC_42 0133-0086 60.653 µM 1.80474170885667 0.0282394587947691 no 146 0.0355575548962706 261 162923 Model of phenazepam hydroxylation.
SGTC_3319 9138450 16.7555 µM 1.79716393327497 0.0287575530428672 no 147 0.036154799218279 261 2029690
SGTC_1451 4152-0210 104 µM 1.79681447154891 0.0287816352125117 no 148 0.0361825390799008 304 659563
SGTC_3234 9132280 49.47 µM 1.79573098271416 0.0288564073950806 no 149 0.036268655942108 289 17612295
SGTC_1210 3013-0140 750 nM 1.78875954856059 0.0293413812856869 no 150 0.0368267740728719 266 905973
SGTC_1770 st043884 66.3 µM 1.78741259701933 0.0294358590469519 no 151 0.0369354135587551 272 670149
SGTC_3063 1327-0034 4 µM 1.78103450262744 0.0298866667392472 no 152 0.0374534072053583 282 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_258 haloperidol 50.781 µM 1.77851117863843 0.0300665908131917 no 153 0.0376599688138927 333 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1101 ebselen 5.29 µM 1.77557024540388 0.0302774246719568 no 154 0.0379018889450241 299 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2739 tacrine 100.86 µM 1.77272331994472 0.0304826848490222 no 155 0.0381372824713037 262 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_381 3461-2219 42.7 µM 1.76697612926553 0.0309005640555803 no 156 0.0386161130392629 316 2883159
SGTC_2475 5812728 15.03 µM 1.76301048553849 0.0311916624481338 no 157 0.038949360599681 312 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1982 st072467 71.9 µM 1.75097031168039 0.0320894000902786 no 158 0.0399755120232062 354 3163533
SGTC_1058 3448-5425 97.3 µM 1.75067456932659 0.0321117168434873 no 159 0.0400009911743146 298 7279705
SGTC_2705 st078069 42.8 µM 1.75042613077242 0.0321304739479336 no 160 0.0400224051495255 268 1530061
SGTC_556 4058-0063 51.5 µM 1.74962157170471 0.0321912802231746 no 161 0.0400918174552602 310 6615692
SGTC_1464 k208-0027 110 µM 1.74723440948385 0.0323722543661042 no 162 0.0402983426307616 308 X1464
SGTC_2807 7945238 51.95 µM 1.74495926553899 0.03254551677332 no 163 0.0404959799099847 329 17148797
SGTC_2455 5377712 9.75 µM 1.73205688388475 0.033542616136655 no 164 0.0416317174449541 275 2243908
SGTC_1594 piperine 70.1 µM 1.72919881015675 0.0337668572925576 no 165 0.0418867596212217 328 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1086 cerivastatin 2.18 µM 1.72570130387638 0.0340429443133189 no 166 0.0422005816790716 264 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1220 1838-0075 193 µM 1.72266825814271 0.0342838680073247 no 167 0.0424742667939391 320 5529645
SGTC_3340 9146634 11.102 µM 1.72187203366639 0.0343473461540762 no 168 0.042546351034473 286 4907387
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.71981989636108 0.0345113959861977 no 169 0.0427325924025454 358 23847180
SGTC_2262 9014885 67.46 µM 1.70896617385453 0.0353897911013674 no 170 0.0437286077173848 214 6457424
SGTC_565 1418-0001 44.5 µM 1.70550418448744 0.0356737977381803 no 171 0.0440502162629121 372 2862145
SGTC_3136 9095672 49.47 µM 1.70472887672552 0.0357376559792208 no 172 0.0441225008109157 274 17217380
SGTC_3165 9101544 49.47 µM 1.70151593273988 0.0360032894032733 no 173 0.0444230742900072 329 5002184
SGTC_2927 9011802 47.9 µM 1.69989183457494 0.0361381774628488 no 174 0.04457563655231 327 43912568
SGTC_3330 9141424 71.43 µM 1.69677080453455 0.0363985535681227 no 175 0.0448700002187355 354 27261020
SGTC_38 0929-0051 58.268 µM 1.68882470689775 0.037068403413428 no 176 0.0456265137938928 359 1379719
SGTC_2697 mebhydrolin 72.4 µM 1.68383271348943 0.0374943539710774 no 177 0.0461070015331066 390 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2313 7726885 200 µM 1.68328948067752 0.0375409464460969 no 178 0.0461595329015226 337 726423
SGTC_2056 5235370 200 µM 1.68246040295369 0.0376121466499912 no 179 0.046239798522038 352 5511916
SGTC_2991 9074669 71.4286 µM 1.67324611832157 0.0384109039999257 no 180 0.047139427419728 411 17333109
SGTC_54 0159-0055 9 µM 1.66998964126651 0.0386964835672499 no 181 0.0474607065543979 333 3319099
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.66690893136015 0.0389682390577844 no 182 0.0477662573392989 343 165521
SGTC_2379 9035213 200 µM 1.6659944867168 0.0390492024586405 no 183 0.0478572562752209 357 646551
SGTC_2193 5925765 200 µM 1.66569311978108 0.0390759149685683 no 184 0.0478872765284938 265 877370
SGTC_2822 7994718 71.43 µM 1.66236994339822 0.0393714616741174 no 185 0.0482193107890641 274 1018011
SGTC_302 1094-0063 18.9 µM 1.66185595473584 0.0394173352436337 no 186 0.0482708299072679 275 5440289
SGTC_2310 7668677 200 µM 1.65715736394582 0.0398387039212411 no 187 0.0487438320009312 347 2197143
SGTC_1365 1672-3266 55.4 µM 1.65444553432854 0.0400835620728091 no 188 0.0490185105777742 350 6415873
SGTC_763 3453-1109 128 µM 1.64809958226471 0.0406613349486789 no 189 0.0496661190159174 363 1560353
SGTC_404 fumagillin 50 µM 1.64618290693698 0.0408371633787848 no 190 0.0498630536669602 371 12015870 A methionine aminopeptidase binder.
SGTC_2445 5742597 35.57 µM 1.64561472140357 0.0408894049106542 no 191 0.0499215531574865 342 1774255
SGTC_2131 toluylene red 5.2905 µM 1.64045089236856 0.0413666799773066 no 192 0.0504557255381822 369 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1547 harmine 94.2 µM 1.63891197448992 0.0415097869960607 no 193 0.0506157967522375 432 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_49 0717-0965 32.132 µM 1.63234384307716 0.0421250863546985 no 194 0.0513035360298093 360 5889349 YGL099W LSG1
SGTC_161 4065-0411 162.148 µM 1.63180057890455 0.0421763078626122 no 195 0.0513607516730174 437 1906281 YLR208W SEC13
SGTC_1493 4348-0038 111 µM 1.62779209832918 0.0425558060088323 no 196 0.051784488284369 386 800424
SGTC_3142 9086498 49.47 µM 1.61875693870958 0.0434213281567306 no 197 0.0527497852752801 333 25236367
SGTC_3004 9076122 71.4286 µM 1.61750330038148 0.043542535211626 no 198 0.0528848419220166 372 44782551
SGTC_1176 0848-0131 83.3 µM 1.61012397550627 0.044261544558493 no 199 0.0536853969812493 392 6769040
SGTC_2928 9011484 9.79 µM 1.60177337748353 0.0450867000459162 no 200 0.0546028660930921 339 2994751
SGTC_456 gingerol 170 µM 1.60006706269448 0.0452568215675988 no 201 0.0547918534485868 369 442793 A herb.
SGTC_2298 7976326 193.81 µM 1.59863177667172 0.0454003207641202 no 202 0.0549512223651701 305 2235818
SGTC_340 k038-0059 454 µM 1.58910808080102 0.0463617885525231 no 203 0.0560179968639396 399 23733424
SGTC_1816 st051957 91.6 µM 1.58448538665848 0.0468343317310351 no 204 0.0565416522684936 348 674121
SGTC_1395 3486-0190 4.35 µM 1.58098951290228 0.0471942478414071 no 205 0.0569402178042927 380 6748079
SGTC_2524 avocatin b 10.57 µM 1.57857922437909 0.0474436867988311 no 206 0.0572163015487494 337 6710748
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.57599293103492 0.0477125140204305 no 207 0.0575137161664245 445 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2612 dictamnine 15.46 µM 1.57562903927364 0.0477504357377313 no 208 0.0575556598482191 396 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3355 9151058 44.0485 µM 1.56841325852793 0.0485073994983366 no 209 0.0583923594347629 370 17015728
SGTC_3059 1327-0034 3 µM 1.55821680279343 0.0495933733934965 no 210 0.0595909315715251 415 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1031 k035-0009 16 µM 1.55452366530513 0.0499914646706781 no 211 0.0600297781032731 435 5180959
SGTC_2329 6138490 200 µM 1.54929080549186 0.0505598845679942 no 212 0.0606559145147806 369 720019
SGTC_1117 retinoic acid 1.10837 µM 1.54522037462017 0.0510055858386605 no 213 0.0611464838556685 430 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1730 st033808 45.1 µM 1.54478792431856 0.0510531211925982 no 214 0.0611987845672561 462 1045166
SGTC_2924 9010168 62.78 µM 1.54397800739313 0.0511422428893791 no 215 0.0612968302787025 428 2993929
SGTC_729 4092-0585 94.1 µM 1.54237296434587 0.0513192244736074 no 216 0.0614914937308154 362 2169061
SGTC_512 prima-1 270 µM 1.54120768495382 0.051448020099494 no 217 0.0616331238692785 402 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2768 sulfasalazine 50.2 µM 1.53838239661322 0.0517613599829121 no 218 0.0619775719068705 386 5384001 An antioxidant and salicylic acid derivative.
SGTC_2963 9082507 9 µM 1.53798817749545 0.0518052013704238 no 219 0.0620257527442943 385 16459611
SGTC_1968 st069590 43.6 µM 1.5330409222507 0.0523579019195446 no 220 0.0626328861774099 389 6384066
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.53166248887642 0.0525127296997888 no 221 0.0628028717550445 215 4000243
SGTC_2681 menadione 3.18 µM 1.53063993871361 0.0526278187393591 no 222 0.0629292026293101 402 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1637 st007924 17.4 µM 1.52840858026708 0.0528796553193828 no 223 0.0632055629053111 401 683336
SGTC_1837 st055472 66.5 µM 1.52762193065318 0.0529686660855423 no 224 0.0633032167591746 405 676091
SGTC_3317 9138495 8.753 µM 1.5247478733325 0.0532948811923643 no 225 0.0636609980061803 414 17020139
SGTC_202 3594-0513 34.79 µM 1.5240933798539 0.053369390539876 no 226 0.0637426931032264 349 708429
SGTC_51 1013-0126 23.419 µM 1.52355873574987 0.0534303171462828 no 227 0.0638094888798763 388 1627850
SGTC_1240 0356-0016 42.1 µM 1.52199218866347 0.0536091540292785 no 228 0.0640055189792729 408 4305613
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.52005517833564 0.0538309382404124 no 229 0.0642485541442042 421 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1338 1486-1223 76 µM 1.51828653268549 0.0540340789842737 no 230 0.0644710906048855 430 3444526
SGTC_421 streptovitacin 30 mM 1.51386414143906 0.0545446759930348 no 231 0.06503015023811 454 91467 include heat shock
SGTC_1757 st041620 31.8375 µM 1.51342099380765 0.0545960502197435 no 232 0.0650863778265727 408 5289815
SGTC_864 0469-0573 172 µM 1.51038956002104 0.054948512009643 no 233 0.0654720254884117 399 689425
SGTC_3238 9133470 49.47 µM 1.5081887515757 0.0552055225812031 no 234 0.0657531126750085 377 3534688
SGTC_2489 cantharidin 73.42 µM 1.5073556858162 0.0553030554408133 no 235 0.065859755541321 459 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.50636551297315 0.0554191588730383 no 236 0.0659866843798064 416 16623 A steroid.
SGTC_1297 1068-0111 14.1 µM 1.49956753478474 0.0562214649578732 no 237 0.0668632312933135 405 767057
SGTC_3199 9111318 49.47 µM 1.49933012826682 0.0562496486041105 no 238 0.0668940050418962 402 8548020
SGTC_2488 5268135 45.7 µM 1.49652259722271 0.0565837892188653 no 239 0.0672587618766075 520 1270356 YLR208W SEC13
SGTC_2114 5491910 81.25 µM 1.49170914935925 0.0571603027476403 no 240 0.0678877047636424 416 2849228
SGTC_3106 9121286 49.47 µM 1.49036312184033 0.0573223428585933 no 241 0.0680643918218905 370 15943471
SGTC_2476 5806916 10.51 µM 1.48823466185867 0.0575793127161807 no 242 0.0683445095818331 394 2870194
SGTC_269 exalamide 29 µM 1.48708184412234 0.0577188706553137 no 243 0.0684965980570232 392 3316 A derivative of salicylamide.
SGTC_858 0438-0351 2.77 µM 1.48537316585279 0.0579262091184419 no 244 0.0687224999773921 446 2799119
SGTC_3079 9117512 49.47 µM 1.4852736340183 0.0579383047655389 no 245 0.0687356766258096 377 7185044
SGTC_2600 tangeritin 87.95 µM 1.48501495548906 0.0579697500645699 no 246 0.0687699312227501 406 68077 A bioactive flavone.
SGTC_3150 9097574 49.47 µM 1.48212521683944 0.0583219430360108 no 247 0.0691534900975638 371 17217476
SGTC_230 MPP+ 141.667 µM 1.48159040159986 0.0583873086955351 no 248 0.0692246572619954 417 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2580 diallyl disulphide 81.36 µM 1.47862774649088 0.0587504501455322 no 249 0.0696199164050955 407 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2038 4100038 30.985 µM 1.47243588445786 0.0595151273026331 no 250 0.0704516044392921 452 3596803
SGTC_2389 9091542 195.52 µM 1.47094298053202 0.0597006587897483 no 251 0.0706532688792833 471 3626624 YOL127W RPL25
SGTC_2086 5274770 176.623 µM 1.46451838793275 0.06050425469242 no 252 0.0715261813343177 428 689278
SGTC_2011 4012611 177 µM 1.46383199608576 0.0605906074496607 no 253 0.0716199288966738 457 2049887
SGTC_2845 9003024 42.97 µM 1.46076270903401 0.0609779245945529 no 254 0.0720402864736713 462 2990173
SGTC_1178 0988-0033 191 µM 1.46041429856017 0.0610220129946916 no 255 0.0720881227079205 485 5392207
SGTC_2161 5662504 8.5105 µM 1.45978410014758 0.0611018225687989 no 256 0.0721747098526195 421 2859334
SGTC_1313 1220-0047 237 µM 1.45783818314447 0.0613487722858048 no 257 0.0724425754314446 498 3528706
SGTC_1860 st056228 74.6 µM 1.45545744079548 0.0616519639621198 no 258 0.0727713321227419 428 688679
SGTC_1698 5-fluorocytosine 1.055 µM 1.45502876616964 0.0617066805085052 no 259 0.0728306489727093 408 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2840 9008771 71.43 µM 1.45288956234613 0.0619802979323646 no 260 0.0731272097106705 380 2992978
SGTC_3087 9117406 49.47 µM 1.45184399849121 0.0621143760378443 no 261 0.0732724934245107 421 42546093
SGTC_1415 3966-0071 78.1 µM 1.45174803285861 0.062126693540255 no 262 0.0732858391449263 439 2893185
SGTC_1413 3910-0535 34.4 µM 1.44985678773392 0.0623698300612498 no 263 0.073549229850378 447 2876951
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.44583790997084 0.0628889560422832 no 264 0.0741113351571772 462 94937 An inhibitor of serotonin biosynthesis.
SGTC_1697 st025554 27.742 µM 1.44340649044163 0.0632046576889493 no 265 0.0744529984123674 418 1269519
SGTC_1290 0986-0249 10.2 µM 1.44296191368638 0.0632625158759605 no 266 0.0745156002024288 404 53329
SGTC_1276 0871-0068 94.2 µM 1.43845945398793 0.0638508017612477 no 267 0.0751518669336835 422 3414906
SGTC_1575 cyproterone acetate 48 µM 1.43708599466355 0.0640311006562124 no 268 0.0753467801154641 460 9880 An androgen receptor antagonist and liver toxin.
SGTC_2028 5153890 36.43 µM 1.43634664308483 0.0641283217372323 no 269 0.0754518639186784 449 2830968 YPR165W RHO1
SGTC_637 1181-0519 7.26 µM 1.43193328019289 0.0647110459406564 no 270 0.0760814583473175 582 6252091 YGR060W ERG25
SGTC_235 0330-0087 5 mM 1.42538060962058 0.0655838111321411 no 271 0.07702360501694 505 46494818 YHR062C RPP1
SGTC_1966 st070145 16.1 µM 1.42436645482527 0.0657197005607433 no 272 0.0771702097464324 460 3748532
SGTC_2663 amphotericin b 100 µM 1.42115720995407 0.066151154690734 no 273 0.0776355306283871 439 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1487 3970-0795 2.82 µM 1.41235383598631 0.0673459555329007 no 274 0.0789229010005227 481 3765103
SGTC_1468 k284-1086 134 µM 1.40419864820812 0.0684676046834185 no 275 0.0801298521473134 552 15996457
SGTC_1648 st011736 69.8 µM 1.39627077840821 0.0695717506610396 no 276 0.0813164849639087 462 2855514
SGTC_1579 chlormadinone acetate 49.4 µM 1.39083757571195 0.070336337386659 no 277 0.0821373429004957 498 45114258 A steroidal progestin.
SGTC_2999 9069765 71.4286 µM 1.38830333397451 0.0706951705903574 no 278 0.0825223487182857 509 2097066
SGTC_2525 harmine 47.85 µM 1.38715761593217 0.0708578583356658 no 279 0.0826968531979119 423 5280953 A monoamine oxidase inhibitor
SGTC_3235 9132602 49.47 µM 1.38600919574265 0.0710212182599776 no 280 0.0828720477837871 525 4912240
SGTC_1606 st000094 49.2 µM 1.38275495834502 0.071485696650406 no 281 0.0833700070327771 508 1242210
SGTC_3281 9140613 49.47 µM 1.38076944966502 0.0717702318645882 no 282 0.083674929837163 435 16013766
SGTC_607 4491-0986 66.8 µM 1.38031748451566 0.0718351223731021 no 283 0.0837444569240432 518 698981 YDR232W HEM1
SGTC_885 0865-0106 16.8 µM 1.37715628281718 0.0722902478363782 no 284 0.0842319673434496 496 2793380
SGTC_566 0958-0068 16.5 µM 1.37652594019589 0.0723812633764305 no 285 0.0843294309725295 432 6815365
SGTC_2929 9013348 24.6 µM 1.37337913861894 0.0728369456365062 no 286 0.0848172558261817 494 2995952
SGTC_449 xestospongin c 11.1929 µM 1.37322903951372 0.0728587359525201 no 287 0.0848405773145831 525 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2750 bromebric acid 70.15 µM 1.3714288796578 0.0731204592877274 no 288 0.0851206499406053 568 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_588 3970-1144 52.9 µM 1.37075924317647 0.073218000399195 no 289 0.0852250099990777 534 1888707
SGTC_2108 5365811 200 µM 1.36833473980663 0.0735719931456071 no 290 0.0856036607151863 505 780283
SGTC_1958 st076513 41.9 µM 1.36798921156575 0.0736225488001707 no 291 0.0856577265384894 517 732122 YGL099W LSG1
SGTC_2320 7373003 200 µM 1.36735125944202 0.0737159599753022 no 292 0.0857576159595097 478 5415828
SGTC_2566 crystal violet carbinol 226 nM 1.36500950368317 0.0740596247886056 no 293 0.0861250315103394 463 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1414 3917-0015 5.4 µM 1.35877095364617 0.0749811377402718 no 294 0.0871095901152697 457 6618702
SGTC_1734 st037168 69.4 µM 1.35833988575141 0.0750451335264754 no 295 0.0871779298021774 501 708907
SGTC_1815 st051655 58.2 µM 1.35457708426116 0.0756055241718698 no 296 0.087776169309515 458 5984156
SGTC_3155 9099265 49.47 µM 1.35211563851611 0.0759738264068258 no 297 0.0881691626425001 459 25236499
SGTC_732 3970-1727 52.7 µM 1.35127370672155 0.0761001163800808 no 298 0.0883038857011663 480 1275699
SGTC_2754 granisetron 64.02 µM 1.35035694980872 0.0762378118130534 no 299 0.0884507564319745 535 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1856 st057054 55.7 µM 1.34970773101622 0.0763354380737142 no 300 0.0885548757576363 525 1266018
SGTC_163 TUB2.036 7.546 µM 1.34842255601076 0.0765289767400453 no 301 0.0887612566227605 695 15992207 YJR013W GPI14
SGTC_105 0111-0055 734.78 µM 1.34204193773353 0.0774953853122293 no 302 0.0897911990888766 418 5179370
SGTC_2009 4012297 12.05 µM 1.33834089512347 0.0780601764302388 no 303 0.0903926682416554 501 45595307
SGTC_1252 0493-0875 34.8 µM 1.33746946259375 0.0781936129478256 no 304 0.0905347218914049 499 3960963
SGTC_1655 st012546 55.1 µM 1.33746460024824 0.0781943579706668 no 305 0.0905355149750149 475 720985 YLR208W SEC13
SGTC_2080 5212524 12.4 µM 1.33703795963241 0.0782597500614459 no 306 0.0906051232176968 494 260183
SGTC_418 lividomycin a 100 µM 1.33621942000489 0.078385325426826 no 307 0.0907387826710134 542 72394 An antibiotic.
SGTC_39 0986-0283 58.349 µM 1.3341250599459 0.0787073249025294 no 308 0.091081437112199 595 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1060 3448-7350 82 µM 1.32976160120086 0.0793814074933163 no 309 0.0917984156271547 567 570178
SGTC_339 3091-4833 71.4 µM 1.32863859004079 0.0795555992486364 no 310 0.0919836170402714 510 3240077
SGTC_2544 sphondin 68.51 µM 1.32002907378386 0.080900653596082 no 311 0.0934126555951332 494 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2913 7966556 36.57 µM 1.3187428951313 0.0811030569854762 no 312 0.0936275405188129 498 2976516
SGTC_3343 9148379 18.9835 µM 1.31845728158148 0.0811480552327954 no 313 0.0936753081407895 530 1955036
SGTC_943 3253-1379 105 µM 1.31783214140808 0.0812466114406756 no 314 0.0937799228997381 529 668464
SGTC_1607 st000305 50.6 µM 1.31732104625529 0.0813272550056634 no 315 0.0938655167310433 542 5457690
SGTC_169 k015-0017 16.025 µM 1.3167591138905 0.0814159896353054 no 316 0.0939596908770605 479 1840002
SGTC_2175 5807670 165.306 µM 1.31139349138779 0.0822669547509557 no 317 0.0948624283222134 516 241186
SGTC_2546 rhodinyl acetate 100 µM 1.30810894607826 0.0827911649724536 no 318 0.0954181797756453 553 6708682
SGTC_1819 st053448 58.6 µM 1.30633303179615 0.0830756439974221 no 319 0.0957196643526946 527 2857616
SGTC_837 0091-0265 12.5 µM 1.30552885844123 0.0832047039602045 no 320 0.0958564135444096 576 759367
SGTC_3034 9090421 49.47 µM 1.30334362245381 0.0835561689054205 no 321 0.0962287372896787 482 17173761
SGTC_1879 gemcitabine 100 µM 1.3022149761474 0.0837381323640308 no 322 0.0964214535179548 549 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1324 1418-0026 34.4 µM 1.30060108301574 0.083998845589071 no 323 0.0966975180763632 566 1372513
SGTC_67 0335-0847 266 µM 1.2981337602384 0.084398601903106 no 324 0.0971206875472366 699 4552207 YOR254C SEC63
SGTC_157 1348-1695 65.819 µM 1.29807735420923 0.0844077574846915 no 325 0.0971303775867249 625 5380510
SGTC_1203 3992-3522 103 µM 1.29456684925051 0.0849790349564601 no 326 0.0977348472533257 589 5322312
SGTC_1219 1469-0211 33.1 µM 1.2938136162218 0.0851019881274847 no 327 0.0978649041407742 523 6822282
SGTC_2543 pimpinellin 60.67 µM 1.29095903183303 0.0855691632459425 no 328 0.0983589419383062 523 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_812 4251-0442 148 µM 1.29052542942881 0.0856402933641163 no 329 0.0984341442306612 530 5723007
SGTC_2673 kobusone 100 µM 1.2870252663267 0.0862160979069386 no 330 0.099042740862109 521 6710676 An epoxy ketone and protein crosslinker.
SGTC_874 0599-0792 117 µM 1.28282555865415 0.0869107988754787 no 331 0.099776598816664 644 765305
SGTC_1631 benzylvanillin 81.9 µM 1.27696829525515 0.0878866585865672 no 332 0.100806720366611 579 75506
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.27538109903216 0.0881524981773822 no 333 0.101087192664637 602 5106787 A p450 inhibitor.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.27437106395671 0.0883219808369992 no 334 0.101265971112751 666 368090
SGTC_646 4092-0839 27.3 µM 1.26978929137895 0.0890938468130294 no 335 0.102079848110572 567 877796
SGTC_895 0964-0006 13.7 µM 1.26823535720941 0.0893567663386723 no 336 0.10235695700696 557 6738897
SGTC_1279 0874-0590 65.2 µM 1.26820523274501 0.0893618689760548 no 337 0.102362334421667 577 3523074
SGTC_2436 5633522 8.09 µM 1.26820088520537 0.0893626054026732 no 338 0.102363110503005 593 5724242
SGTC_3174 9107204 49.47 µM 1.26698220484211 0.0895692148428092 no 339 0.102580826451516 564 3938802
SGTC_1660 st012960 28.1 µM 1.26634808685024 0.089676860682175 no 340 0.102694244011045 562 24207266
SGTC_975 1335-0046 28.5 µM 1.26611696156112 0.089716119679704 no 341 0.102735605449401 558 16486740
SGTC_3298 9116858 71.43 µM 1.26237956080408 0.0903527304253801 no 342 0.10340612016261 600 2506942
SGTC_2716 st080858 38.6235 µM 1.26189982487537 0.0904346886508598 no 343 0.103492417519822 559 5296050
SGTC_1695 st026914 34.495 µM 1.25910255186348 0.0909136751748977 no 344 0.103996646420563 574 3289191
SGTC_1907 st060210 83.7 µM 1.25497448976413 0.0916239717308736 no 345 0.104744010389846 637 688793
SGTC_33 0986-0033 35.816 µM 1.25195842136417 0.0921455265425594 no 346 0.105292507501378 532 2848082
SGTC_604 1000-0114 314 µM 1.24817996291727 0.0928020152876049 no 347 0.105982580023153 616 1572745
SGTC_1128 3448-9350 235 µM 1.24707992581304 0.0929937898495956 no 348 0.106184096358164 526 619386
SGTC_41 0478-0632 82.643 µM 1.24530010835211 0.0933046938522756 no 349 0.106510727931426 664 3750424
SGTC_2853 9015042 58.44 µM 1.2447746494314 0.0933966293024976 no 350 0.106607298541478 542 6457456
SGTC_702 1488-0190 94 µM 1.24467196950122 0.0934146022221829 no 351 0.10662617678428 587 949357
SGTC_1750 st081859 2.357 µM 1.24438023341794 0.0934656811492117 no 352 0.106679827157699 768 5291695
SGTC_1349 flufenamic acid 69 µM 1.24323431191352 0.0936665157133885 no 353 0.106890751105304 543 3371 A non-steroidal anti-inflammatory.
SGTC_845 0330-0138 4.51 µM 1.24237743149749 0.0938169009279265 no 354 0.107048669219968 584 9039800
SGTC_2141 5621638 7.665 µM 1.23974163329502 0.0942806090507062 no 355 0.107535486364798 569 2856238
SGTC_2288 7946289 167.31 µM 1.23697889518121 0.0947684615691837 no 356 0.108047458961534 657 1246052
SGTC_905 2-aminofluorene 215 µM 1.23657529161984 0.0948398865400554 no 357 0.108122398811661 634 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3101 9120531 49.47 µM 1.23642364660272 0.0948667331253528 no 358 0.108150565453792 609 24824904
SGTC_1767 st044992 70.3 µM 1.23588888548674 0.0949614496347415 no 359 0.108249934479353 596 9600693
SGTC_3299 9121982 43.1275 µM 1.23000507399079 0.0960081897327793 no 360 0.109347602397869 606 17594604 YPL160W CDC60
SGTC_1255 0566-0045 221 µM 1.22685522741811 0.0965720276819798 no 361 0.109938504516159 612 2788469
SGTC_548 1436-0017 110 µM 1.22252966014066 0.0973502840798008 no 362 0.110753697307251 692 9677137
SGTC_819 1013-0258 27.7 µM 1.22157771803827 0.0975221735906431 no 363 0.110933679531535 600 5753198
SGTC_2477 5967686 25.23 µM 1.21716848740873 0.098321239636959 no 364 0.111770058625652 596 776118
SGTC_2505 galangin 7.89 µM 1.21011110770463 0.0996101811607489 no 365 0.113118130735498 526 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2684 capsaicin 100 µM 1.20935764805045 0.0997485171960988 no 366 0.113262736086897 575 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2720 fluspirilene 36.88 µM 1.20519767258733 0.100514820570485 no 367 0.114063500331246 550 3396 An atypical antipsychotic.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.20133814708516 0.101229611247193 no 368 0.114810029314196 652 442882
SGTC_911 3456-4043 236 µM 1.19832286443407 0.101790618578428 no 369 0.115395674350009 654 914281
SGTC_658 3253-0951 102 µM 1.19457981899378 0.102490173749594 no 370 0.11612561896402 733 1184878
SGTC_1556 plumbagin 1.48 µM 1.19291535069918 0.102802374272135 no 371 0.116451263327566 556 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_497 capsazepine 133 µM 1.18891011229637 0.103556458657106 no 372 0.1172375202115 609 2733484 A calcium channel blocker.
SGTC_2312 7706453 155.7 µM 1.1879346633391 0.103740717189578 no 373 0.117429575910943 628 976098
SGTC_1943 st076331 65.2 µM 1.186357382849 0.104039162407071 no 374 0.117740597119133 652 24208415
SGTC_3287 9117173 37.0625 µM 1.18491975919398 0.104311724309453 no 375 0.11802458707789 574 2789709
SGTC_691 1548-0686 185 µM 1.1843584113809 0.104418291712974 no 376 0.118135607846897 649 46495133
SGTC_2539 epi(13)torulosol 80 µM 1.18421712912238 0.104445125444334 no 377 0.118163561626802 607 6708597
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.18172961678266 0.104918397205005 no 378 0.118656501398151 668 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_954 1189-0853 2.85 µM 1.18138518434961 0.104984050773155 no 379 0.118724870463687 659 2828194
SGTC_2115 tiliquinol 12.7705 µM 1.17485452527715 0.106234516643746 no 380 0.120026460768476 620 71208 A bioactive hydroxyquinoline.
SGTC_2875 9039966 71.43 µM 1.1734858228406 0.106497948638888 no 381 0.120300519420218 593 6463691
SGTC_1811 st050069 61.5 µM 1.17346734618871 0.106501508034192 no 382 0.120304222058796 599 3877702
SGTC_2597 laccaic acid a 100 µM 1.1728922483721 0.106612339473121 no 383 0.120419509234519 663 5491415 A textile dye.
SGTC_522 1273-0010 11.6 µM 1.16904543013817 0.107355830184216 no 384 0.12119266407316 619 5705015
SGTC_1633 st005664 67.9 µM 1.16819151392794 0.10752137587146 no 385 0.121364761368214 658 2063822
SGTC_779 1360-0071 233 µM 1.16664434187492 0.107821789067593 no 386 0.121677014211697 711 7566
SGTC_3290 9121031 71.43 µM 1.16652934442948 0.107844142146146 no 387 0.121700245707836 583 17014854
SGTC_1889 st059080 5.18 µM 1.16577255757861 0.10799132881382 no 388 0.121853207642604 703 176925 Isolated from Daphnopsis sellowiana.
SGTC_2912 7964298 10.93 µM 1.16111803743239 0.108899762722474 no 389 0.122796950192823 714 2975850
SGTC_2960 9079389 5.97 µM 1.16035612210829 0.109048989293478 no 390 0.122951921752992 668 16457355
SGTC_206 4546-0025 72.014 µM 1.15805890401759 0.109499805335048 no 391 0.123419999616586 742 6620745 YIL048W NEO1
SGTC_507 nimesulide 162 µM 1.15457345675389 0.110186357985712 no 392 0.124132570745717 677 4495 A COX2 inhibitor.
SGTC_1784 st039334 36.3 µM 1.15289570839504 0.110517934280456 no 393 0.124476596896075 654 3496984
SGTC_814 3342-0569 96 µM 1.15208495859321 0.110678420246444 no 394 0.124643081692443 689 4346283
SGTC_1938 st074717 56.4 µM 1.15202241980389 0.110690806583535 no 395 0.124655930289265 592 17250979
SGTC_2263 7948595 193.29 µM 1.15119463187902 0.110854850599777 no 396 0.12482608657965 595 2971371
SGTC_1076 itraconazole 331 nM 1.14928784712913 0.111233383594511 no 397 0.125218653800849 671 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_135 0933-0004 26.348 µM 1.14928765745908 0.111233421293592 no 398 0.125218692892787 638 21230617 YGL099W LSG1
SGTC_2118 5526350 200 µM 1.14912121964948 0.111266506228988 no 399 0.125252999836356 673 743594
SGTC_1305 1181-0477 144 µM 1.14769166082099 0.111550967755398 no 400 0.125547937487536 656 6252086
SGTC_1303 1160-0052 261 µM 1.14670061223792 0.111748477272135 no 401 0.125752688680531 666 3562476
SGTC_2205 7238770 200 µM 1.13981094231199 0.113128459716712 no 402 0.127182536995988 646 279867
SGTC_1281 0884-0031 11.8 µM 1.13570773070525 0.113956077000587 no 403 0.128039452042068 702 1548255
SGTC_2687 chenodiol 100 µM 1.13430403616767 0.114240189908236 no 404 0.128333518358453 643 5702181 A cholesterol synthesis inhibitor.
SGTC_1394 3474-0001 65.7 µM 1.13407321811996 0.114286956577073 no 405 0.128381918332346 590 5017666 YIL048W NEO1
SGTC_50 0929-0078 56.389 µM 1.1329278439549 0.114519225603685 no 406 0.128622277995912 651 1377751
SGTC_839 0122-0028 230 µM 1.13186870965058 0.114734304977659 no 407 0.128844817739991 719 759448
SGTC_888 0916-0002 6.97 µM 1.13045856555058 0.115021110082233 no 408 0.1291415241345 701 2802138 YIL048W NEO1
SGTC_3117 9124945 49.47 µM 1.12965933958137 0.115183888517361 no 409 0.129309898282881 600 17592065
SGTC_2008 4012253 172 µM 1.12880261326652 0.115358559855622 no 410 0.129490555009254 696 603940
SGTC_140 0062-0056 502.533 µM 1.12772612801557 0.115578302929171 no 411 0.129717799809305 721 3758964
SGTC_3061 glucosamine 200 µM 1.12591921118999 0.115947817298441 no 412 0.130099858447383 648 91431 and experimental redox chemotherapeutic
SGTC_1892 st058411 7.36 µM 1.12530496569617 0.116073621280255 no 413 0.130229913112045 747 3934738
SGTC_1929 genistein trimethyl ether 50.5 µM 1.12129675956155 0.116896923529288 no 414 0.131080782214245 689 136420
SGTC_3264 9137442 49.47 µM 1.12059693945957 0.117041092863238 no 415 0.131229734177122 649 17015726
SGTC_1971 st069429 63.5 µM 1.11861577920838 0.117449913038192 no 416 0.131652044432338 662 1246522 YGL099W LSG1
SGTC_3118 9124250 49.47 µM 1.11802093533349 0.117572858539301 no 417 0.131779026067675 612 1504786
SGTC_3081 9117243 49.47 µM 1.1168165875056 0.117822058465254 no 418 0.13203637750608 666 45595589
SGTC_1300 1094-0077 113 µM 1.11300237985118 0.118613747954349 no 419 0.132853703693754 657 5532636
SGTC_2184 6075246 200 µM 1.10997399628604 0.119245000721228 no 420 0.133505116036014 696 2267320
SGTC_2887 9044784 58.44 µM 1.10847886783861 0.119557526215085 no 421 0.133827530298976 754 6465546
SGTC_538 2922-0838 53.3 µM 1.10811846786513 0.119632946677641 no 422 0.133905328083296 769 777039
SGTC_1430 4049-0248 69.1 µM 1.10695697589961 0.119876239003265 no 423 0.134156265158598 776 22774488
SGTC_1306 1185-0270 9.02 µM 1.10638232420028 0.11999673752024 no 424 0.134280536415206 747 1548076
SGTC_668 1682-0499 62.6 µM 1.10589503373299 0.120098984162727 no 425 0.134385977300595 739 682214
SGTC_683 panaxydol 45 µM 1.10387764214559 0.120522940368515 no 426 0.134823109321561 734 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3246 9135460 32.98 µM 1.10083724007826 0.121163872075724 no 427 0.135483750357577 621 41446951
SGTC_881 0833-0569 170 µM 1.09853426810474 0.121650942963179 no 428 0.135985631269532 704 5418700
SGTC_1123 mangostin 811.285 nM 1.09400988677576 0.122611837726705 no 429 0.13697532103811 682 5281650 An antioxidant.
SGTC_1786 berberine 21.6 µM 1.09182447366825 0.123077881184798 no 430 0.137455129832232 691 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_485 niflumic acid 177 µM 1.09123335773218 0.123204150841335 no 431 0.137585106629265 676 4488 A COX2 inhibitor.
SGTC_630 4356-0227 183 µM 1.0883440334146 0.123822652435605 no 432 0.138221629140882 686 779312
SGTC_2366 9070441 60.58 µM 1.0857961633081 0.12436986145361 no 433 0.138784592110896 732 6837235
SGTC_2678 equilin 100 µM 1.08430180047623 0.124691593187087 no 434 0.139115503632165 736 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_894 0960-0238 55.9 µM 1.08413907931213 0.124726661641658 no 435 0.139151568982218 740 6741907 YDL195W SEC31
SGTC_1602 st001878 87.6 µM 1.082239797441 0.125136490528481 no 436 0.139572994453632 717 595405 YLR310C CDC25
SGTC_1998 st075797 76.8 µM 1.08153040230292 0.125289805457069 no 437 0.139730622240495 815 24208315
SGTC_3211 9128781 49.47 µM 1.08134755413002 0.125329343968776 no 438 0.139771270762953 686 17194361
SGTC_505 gw-5074 63.9 µM 1.08060534499505 0.125489926365333 no 439 0.139936351964745 730 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_757 1066-0008 322 µM 1.07927567402906 0.12577796938288 no 440 0.140232426882735 766 6842497
SGTC_670 4204-0025 119 µM 1.07918950474338 0.125796651900705 no 441 0.140251628677949 761 719039
SGTC_1134 3477-0009 42.5 µM 1.07551784407035 0.126594510185127 no 442 0.14107147378235 788 3973534
SGTC_2096 5468907 200 µM 1.07114620321398 0.127549063405923 no 443 0.142051848115172 723 759785
SGTC_1228 0124-0032 52.5 µM 1.06846510662303 0.128136953893536 no 444 0.142655381046306 752 X1228
SGTC_785 1270-0111 65.3 µM 1.06843302231985 0.128144000472684 no 445 0.142662613921829 716 6741994
SGTC_3128 9127691 49.47 µM 1.06718634756541 0.12841801232969 no 446 0.142943848130076 620 41316314
SGTC_417 st075190 100 µM 1.06676411027088 0.128510909773292 no 447 0.143039184451339 767 222757
SGTC_1280 0880-0253 10.1 µM 1.06665179785206 0.128535627750499 no 448 0.143064550534649 750 6836607
SGTC_2725 haloperidol 53.21 µM 1.06480362606275 0.128942851632858 no 449 0.143482401954973 739 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3162 9099653 49.47 µM 1.06196453184114 0.129570155589464 no 450 0.14412589357552 678 25237511
SGTC_3039 9090270 49.47 µM 1.06172146868123 0.129623958993567 no 451 0.144181075062454 697 17173750
SGTC_1115 galangin 695.678 nM 1.06126889538101 0.1297241798798 no 452 0.144283858599692 799 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_972 1319-0219 195 µM 1.05985889071807 0.130036764813495 no 453 0.144604400140969 735 23903702
SGTC_2057 5236571 38.335 µM 1.05939212992124 0.130140356106154 no 454 0.1447106161956 758 54684039 YBR257W POP4
SGTC_606 k015-0008 38.6 µM 1.05905533822051 0.130215137963191 no 455 0.144787289120687 823 1970475
SGTC_1521 st012942 49.4 µM 1.05465147880584 0.131195715808622 no 456 0.145792375305542 805 24207259
SGTC_2348 9022543 33.42 µM 1.05381938582561 0.131381563744424 no 457 0.145982808126463 765 3162678 YDL140C RPO21
SGTC_1167 k781-0610 148 µM 1.05323993083304 0.13151109231232 no 458 0.146115520886221 797 4525169
SGTC_1190 1486-1332 13 µM 1.05187901456451 0.131815651505537 no 459 0.146427530572182 750 4150046
SGTC_3099 9120367 49.47 µM 1.05093721141501 0.132026702127714 no 460 0.146643714214543 754 24824940
SGTC_978 1416-0512 87.4 µM 1.05027178703458 0.132175958876214 no 461 0.146796586305512 785 6814003
SGTC_1081 sertraline 6 µM 1.04828179113313 0.132623015107313 no 462 0.147254398228623 776 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_9 0092-0002 10.449 µM 1.04768272782538 0.132757799525312 no 463 0.147392403977353 768 759368
SGTC_97 0535-0701 19.132 µM 1.04704108903448 0.132902267686009 no 464 0.147540313906139 711 2832013 YGL099W LSG1
SGTC_1950 st077106 7.18 µM 1.04536377248993 0.133280435029082 no 465 0.147927436806754 763 13831864
SGTC_395 anisomycin 6.25 µM 1.04408937408403 0.133568255062148 no 466 0.148222020801636 688 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1343 1487-0095 224 µM 1.0439350788268 0.133603131286982 no 467 0.148257713592219 764 4560101 YGL055W OLE1
SGTC_352 k048-0007 5.11 µM 1.0438664918328 0.133618636401288 no 468 0.148273581520246 808 6811911
SGTC_2219 9098279 200 µM 1.04329490176289 0.133747900995594 no 469 0.148405865795339 748 902349
SGTC_21 0849-0113 22.993 µM 1.04302048338522 0.133809991005462 no 470 0.14846940304539 764 1560156
SGTC_3249 9135183 49.47 µM 1.037404153213 0.135085097356022 no 471 0.149773771782509 796 4902779
SGTC_861 0443-0273 110 µM 1.03586127022558 0.135436840752433 no 472 0.150133434177485 772 6149169
SGTC_600 1495-0418 41.6 µM 1.03422813015663 0.135809844043301 no 473 0.1505147631976 746 5377768
SGTC_1033 k072-0102 21.3 µM 1.03337496988841 0.136004982266764 no 474 0.150714227655393 793 5965931
SGTC_321 4534-3890 65.3 µM 1.03234125067606 0.136241675720205 no 475 0.150956141583809 772 699746
SGTC_1472 k841-0093 193 µM 1.03169388046836 0.136390049263445 no 476 0.151107772542014 808 X1472
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.03075821477208 0.136604693760943 no 477 0.151327108835574 836 91467 include heat shock
SGTC_1088 bifonazole 369 nM 1.02950959870346 0.136891489641175 no 478 0.151620135793021 763 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_205 1486-1330 71.903 µM 1.02838002829173 0.137151296108161 no 479 0.151885549675455 724 4118834
SGTC_143 4032-1194 15.74 µM 1.0269063381168 0.137490757836776 no 480 0.152232284770357 850 1806963
SGTC_2651 TUB2.036 5 µM 1.02605147276574 0.137687937106969 no 481 0.152433661205696 939 15992207 YFL037W TUB2
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.02303543983107 0.138385142252852 no 482 0.153145544857562 759 6710655
SGTC_1089 terbinafine 2.25 µM 1.02239326902389 0.138533900659984 no 483 0.153297402491833 775 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_427 1354-0053 47.3 µM 1.02080936618919 0.138901276282101 no 484 0.153672383010373 759 6813657
SGTC_925 2064-1272 59.6 µM 1.01943925846274 0.139219598207282 no 485 0.153997238134766 738 6815817
SGTC_253 dyclonine 31.25 µM 1.01615015802393 0.13998579149312 no 486 0.154778943448162 847 3180 An oral anasthetic.
SGTC_540 1187-0821 17.3 µM 1.01494445348163 0.140267375768546 no 487 0.155066153162545 771 847520
SGTC_1274 0865-0114 173 µM 1.01458282573511 0.140351906465565 no 488 0.155152364716305 783 870624
SGTC_366 0181-0206 4.31 µM 1.01388561927604 0.14051497650441 no 489 0.155318667066145 812 274874
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.01276709843998 0.140776856614042 no 490 0.155585709806747 751 689007
SGTC_272 doxorubicin 8.13 µM 1.01267571387721 0.14079826717351 no 491 0.155607540910056 822 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3131 9127911 49.47 µM 1.01118674467315 0.141147430192776 no 492 0.155963529405014 753 45595681
SGTC_1169 aniline yellow 25.8 µM 1.0092807590665 0.141595239619416 no 493 0.156420002557098 763 6051 A DNA damaging agent.
SGTC_2994 9053520 71.4286 µM 1.00908976335442 0.14164016687345 no 494 0.156465793439589 801 4647384
SGTC_3193 9111931 49.47 µM 1.00900090384975 0.141661072275441 no 495 0.156487100356283 791 17087244
SGTC_1328 1441-0025 69.2 µM 1.00645891582717 0.142259994588571 no 496 0.157097432572284 744 4562601
SGTC_853 0419-0306 21 µM 1.0062289107287 0.142314270902331 no 497 0.157152734010011 720 762713
SGTC_662 k832-1615 104 µM 1.00613464278994 0.142336520179238 no 498 0.157175403086413 775 5878478
SGTC_1461 k072-0203 53.8 µM 1.00510549932142 0.142579573431539 no 499 0.157423026167306 763 5418714
SGTC_1216 1165-0504 9.65 µM 1.00373864613334 0.142902817422142 no 500 0.15775230208378 821 6304004
SGTC_408 cantharidin 100 µM 1.00347775911958 0.142964570238696 no 501 0.157815201329429 801 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_86 0417-1630 471.922 µM 1.00274035547669 0.143139213619376 no 502 0.157993076675587 895 3634867
SGTC_3076 9116187 49.47 µM 1.0017110534449 0.143383229798449 no 503 0.158241583298846 763 27241210
SGTC_1871 st057448 67.3 µM 0.999462029759707 0.143917381716709 no 504 0.158785461994882 837 691747
SGTC_2085 5307070 144.047 µM 0.998808586618331 0.144072828343589 no 505 0.15894371282517 750 2840351
SGTC_179 1273-0063 6.77 µM 0.996975623796441 0.144509473224388 no 506 0.159388171066095 752 3108139
SGTC_584 0986-0246 15.4 µM 0.995874813961378 0.144772134135619 no 507 0.159655487007404 879 53315 YDR232W HEM1
SGTC_1912 st060209 90.8 µM 0.9950540825459 0.144968175469981 no 508 0.159854980705125 754 688787
SGTC_3228 9131799 49.47 µM 0.992942145255013 0.145473457773179 no 509 0.160369074789339 779 17015818
SGTC_2218 6965428 192.983 µM 0.992882269771222 0.145487800265085 no 510 0.160383665590557 808 675684
SGTC_2022 5136654 200 µM 0.992648285737542 0.145543857601518 no 511 0.160440692479891 778 1713771
SGTC_458 nppb 133 µM 0.991433936944219 0.145835021667843 no 512 0.160736867902296 790 4549 A chloride channel blocker.
SGTC_281 1672-3440 14.9 µM 0.990699773001499 0.146011241705537 no 513 0.160916100980153 875 6833000
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.986834098953998 0.146941471606487 no 514 0.161861987656717 787 115019
SGTC_2858 9025781 8.96 µM 0.984667503630703 0.147464572219213 no 515 0.162393709966568 905 4894980 YPL153C RAD53
SGTC_199 4063-0024 41.6 µM 0.981855213096928 0.148145427570126 no 516 0.163085591380158 842 306215
SGTC_2737 bleomycin 30.5 nM 0.981749531972262 0.148171053905718 no 517 0.163111628411831 872 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1965 Pectolinarigenin 58.4 µM 0.978753390487351 0.148898814409909 no 518 0.163850922323061 820 5320438 An anti-inflammatory.
SGTC_2339 9000433 200 µM 0.976663122584313 0.149407950956878 no 519 0.164367978879144 722 2988954
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.975771487204513 0.149625484024787 no 520 0.164588858672931 842 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2874 9043904 71.43 µM 0.974579882461834 0.149916530665859 no 521 0.16488434833647 739 4463428
SGTC_3351 9150312 21.596 µM 0.974350034358751 0.149972713928338 no 522 0.164941384707836 804 4904905
SGTC_1659 st012954 42.1 µM 0.973736831405106 0.150122671788491 no 523 0.165093612362007 816 24207262
SGTC_2124 5246320 200 µM 0.972843077217575 0.150341416985951 no 524 0.165315649704422 809 579342
SGTC_3202 9113761 49.47 µM 0.97271873910618 0.150371865400418 no 525 0.165346554602303 894 4798415
SGTC_2374 9071832 200 µM 0.971001223327159 0.1507928779047 no 526 0.165773834697866 818 17381698
SGTC_2225 6654152 15.4 µM 0.968534068771468 0.151399020481922 no 527 0.166388856410232 778 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1925 st057770 10.1 µM 0.965462660559099 0.15215588012829 no 528 0.167156564799182 748 5989122
SGTC_3219 9131112 49.47 µM 0.964947350326137 0.152283109116039 no 529 0.16728559161124 803 17612988 YMR079W SEC14
SGTC_3075 9116269 49.47 µM 0.964322530508002 0.152437470490978 no 530 0.167442124243129 825 17015205 YNL244C SUI1
SGTC_53 0973-0023 39.979 µM 0.959708189364692 0.153580655089135 no 531 0.168601050247427 837 674768
SGTC_2627 acetyl isogambogic acid 100 µM 0.959044985841049 0.153745426522386 no 532 0.168768041538838 792 6857789 A caspase activator and apoptosis inducer.
SGTC_3129 9127257 49.47 µM 0.958981872079764 0.153761113091264 no 533 0.168783938801281 710 837894
SGTC_2620 irigenin 100 µM 0.958599009181017 0.153856294208813 no 534 0.168880395951462 866 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1094 duloxetine 25.4 µM 0.957536637890219 0.154120607782498 no 535 0.169148231519758 835 60834 A selective serotonin reuptake inhibitor.
SGTC_1166 k206-0078 225 µM 0.957515794107388 0.154125796631929 no 536 0.169153489194989 868 5404595
SGTC_1690 st023502 41.2 µM 0.956661947005548 0.154338452578413 no 537 0.169368955394683 827 24207482
SGTC_1400 3771-8998 51.5 µM 0.956342476993471 0.154418068429037 no 538 0.169449618124805 808 670767
SGTC_805 3852-0218 479 µM 0.955360032643874 0.154663075738731 no 539 0.169697829165083 784 6615355
SGTC_675 1309-0189 238 µM 0.954937654894263 0.154768489514619 no 540 0.169804613032841 808 4246530
SGTC_361 000s-0510 1.45 µM 0.954294915798536 0.154928990426133 no 541 0.169967190436752 822 660
SGTC_2249 haloperidol 116.36 µM 0.95408075128888 0.154982494698412 no 542 0.170021384356056 960 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_679 0422-0091 41.4 µM 0.952150554215291 0.155465262333712 no 543 0.170510316696193 879 627384 YHR062C RPP1
SGTC_412 gemfibrozil 100 µM 0.951429332077887 0.155645903816999 no 544 0.170693238105436 804 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3304 9125678 46.087 µM 0.94943526394225 0.15614606992318 no 545 0.171199641105189 826 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_282 k297-0036 65.7 µM 0.948583691276071 0.15635998967977 no 546 0.171416194426511 830 5061378
SGTC_330 1488-0319 80.1 µM 0.948403238806469 0.156405345110171 no 547 0.171462105620121 847 6846614
SGTC_3284 9108171 64.8615 µM 0.947773864302755 0.156563601666771 no 548 0.171622294239058 812 8687505
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.947140041024024 0.156723083378207 no 549 0.171783711759346 926 1273210
SGTC_217 ketoconazole 989 nM 0.944192169638538 0.157466227171111 no 550 0.172535727955962 856 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1460 k062-0059 9.15 µM 0.943961144893341 0.157524565066542 no 551 0.172594752061329 823 1373085
SGTC_474 dl-dihydrosphingosine 5 µM 0.943848892376075 0.157552915968597 no 552 0.17262343590645 860 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2302 7771753 200 µM 0.943823887995367 0.157559231622071 no 553 0.172629825680699 860 2203047
SGTC_2638 epoxomicin 18 µM 0.943323482129032 0.157685660053704 no 554 0.172757734200314 912 9915668 A protesome inhibitor.
SGTC_1457 k015-0032 57.3 µM 0.942485174513843 0.157897609262777 no 555 0.172972148965233 856 4302660
SGTC_2698 st077697 67.5 µM 0.941404740995214 0.15817105092808 no 556 0.173248742475187 811 3154499
SGTC_23 0213-0011 39.996 µM 0.940812654914273 0.15832103085861 no 557 0.173400437290078 855 627608
SGTC_3220 9131269 49.47 µM 0.940278527219789 0.158456409514477 no 558 0.173537355453438 845 17722206
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.936927239518038 0.159307550731398 no 559 0.174397993186326 856 7104
SGTC_245 methotrexate 289.6 µM 0.935420662712226 0.159691156306952 no 560 0.174785776208482 893 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3270 9137563 49.47 µM 0.935160802319084 0.15975738319795 no 561 0.174852717877374 828 17015724
SGTC_933 2914-0560 114 µM 0.933688886153653 0.160132848467105 no 562 0.175232199778912 941 463887
SGTC_656 4090-1979 187 µM 0.933602738102175 0.160154841488938 no 563 0.175254426196446 933 22330961
SGTC_3269 9137823 49.47 µM 0.932994424216993 0.160310196158267 no 564 0.175411423613179 796 17682936
SGTC_2743 auranofin 4.32 µM 0.932008253435582 0.160562259259868 no 565 0.175666130044938 853 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_93 0109-0045 59.227 µM 0.930693564061721 0.160898693400126 no 566 0.176006049909969 1027 88733
SGTC_1323 1348-1351 11.2 µM 0.928053541427771 0.161575674346323 no 567 0.176689898543087 843 6989654
SGTC_2972 9093619 59.92 µM 0.925046409003305 0.162349052125873 no 568 0.177470883748043 842 25236256
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.922993506104188 0.162878401716233 no 569 0.178005294701621 918 4174840
SGTC_2772 vinpocetine 57.06 µM 0.922692322153583 0.1629561575555 no 570 0.17808378406787 854 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_106 0092-0003 11.579 µM 0.921245954640429 0.163329898469266 no 571 0.178461015333685 826 1072148
SGTC_2473 5854593 8.94 µM 0.919534489897336 0.163772859162166 no 572 0.178908037072115 860 2872951
SGTC_3028 9087778 49.47 µM 0.919336369403608 0.163824186948359 no 573 0.178959830129433 919 17217395
SGTC_2411 st077133 39.94 µM 0.918527153294083 0.164033941861758 no 574 0.179171474990133 942 1403142 YNL221C POP1
SGTC_643 k048-0106 28.4 µM 0.917893753090428 0.164198245472433 no 575 0.17933724621952 877 6763920
SGTC_154 3389-1638 511.116 µM 0.917500420240236 0.164300329463524 no 576 0.179440236404765 778 5238686
SGTC_1433 4060-0023 7.6 µM 0.916715694762387 0.164504116808776 no 577 0.179645819809699 905 3840627
SGTC_650 1328-0195 38 µM 0.915970472262693 0.164697797121853 no 578 0.179841191133185 903 2780821
SGTC_2275 7947463 200 µM 0.914850784042495 0.164989077187432 no 579 0.180134985091614 867 1225414
SGTC_2520 obtusaquinone 4.71 µM 0.913861526431855 0.165246703894279 no 580 0.180394806016785 915 5967872
SGTC_3149 9097855 49.47 µM 0.913188782949054 0.165422051277535 no 581 0.18057163117925 873 25236625 YMR079W SEC14
SGTC_2652 actinonin 100 µM 0.913107634470435 0.165443210374552 no 582 0.180592967742535 871 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2167 5876490 200 µM 0.910073390789333 0.166235632166722 no 583 0.181391903264479 906 686534
SGTC_1494 4358-1428 177 µM 0.908548633218808 0.166634761142642 no 584 0.181794215663172 938 1564571
SGTC_1388 3346-4487 254 µM 0.907708870495686 0.166854845965951 no 585 0.182016028051318 948 3345614
SGTC_1792 st045773 43.6 µM 0.90738934425608 0.166938636555661 no 586 0.182100471171387 874 2919270
SGTC_2529 gangaleoidin 93.61 µM 0.9034559877849 0.167972318411905 no 587 0.183141968455288 908 4565183
SGTC_2835 9006588 71.43 µM 0.902124563654031 0.168323146508171 no 588 0.183495350847824 836 2345538
SGTC_402 epigallocatechin gallate 10 µM 0.889071884509213 0.171787436516169 no 589 0.186982223978621 934 65064 An antioxidant.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.885648799913765 0.172703436012154 no 590 0.187903403121643 909 688662
SGTC_1654 st012436 41.8 µM 0.884620585247242 0.172979187849183 no 591 0.188180650172498 885 4323132
SGTC_1392 3455-1037 33.9 µM 0.883061804085844 0.173397764368678 no 592 0.188601439923025 905 981132
SGTC_1230 0170-0365 3.77 µM 0.882857061172421 0.173452791458259 no 593 0.188656752919461 1056 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.879908979247872 0.174246355455413 no 594 0.189454310006523 913 4330530
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.879074836864778 0.174471307796495 no 595 0.189680350139484 945 2724 A muscle relaxant with antifungal properties.
SGTC_2200 6600604 21.907 µM 0.879018740630965 0.174486442501003 no 596 0.189695557332113 943 2904777
SGTC_2648 atorvastatin 78.68 µM 0.878263959059987 0.174690162857209 no 597 0.189900244857116 928 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2062 5245942 200 µM 0.877485226628647 0.174900505908186 no 598 0.190111569822791 1017 1376160
SGTC_277 nystatin 15.5 µM 0.877045642483942 0.175019312717327 no 599 0.19023092375486 997 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_204 PMA1.184 62.41 µM 0.874955273485387 0.175584979100315 no 600 0.190799121162473 1000 2252213 YGL008C PMA1
SGTC_1226 3909-7979 35.4 µM 0.874811924120383 0.17562381270161 no 601 0.190838124045747 974 6615510
SGTC_727 3032-0951 202 µM 0.870280457770428 0.176854199485633 no 602 0.192073577929299 904 3652836
SGTC_3071 9117417 49.47 µM 0.869516715174497 0.177062106621863 no 603 0.192282284751293 871 45595590 YGL055W OLE1
SGTC_130 0136-0219 337.655 µM 0.865090140499443 0.178270154456463 no 604 0.193494657902082 948 234244
SGTC_1378 2093-0007 380 nM 0.864393324019485 0.178460793368964 no 605 0.193685929501815 920 3618014
SGTC_3014 9081533 49.47 µM 0.864376924202768 0.17846528166793 no 606 0.19369043253317 958 21367265
SGTC_1002 4049-0206 172 µM 0.864109962486058 0.178538353703537 no 607 0.193763743364594 985 4662749
SGTC_882 0843-0131 351 µM 0.861269135428436 0.179317104019604 no 608 0.194544915288052 1003 5425421
SGTC_1967 st070177 51.4 µM 0.860635106558456 0.179491200221666 no 609 0.194719522103064 937 5729214
SGTC_765 1319-0117 244 µM 0.859060743239261 0.179923959488976 no 610 0.195153502098967 967 3487746 YGL099W LSG1
SGTC_949 1165-0505 146 µM 0.853006473402302 0.181594248439161 no 611 0.196827857189737 991 6244267
SGTC_924 2046-0044 21.3 µM 0.852811867167868 0.181648098072754 no 612 0.196881820946297 1016 3623589
SGTC_1791 st048313 56.1 µM 0.85119421869028 0.182096105429771 no 613 0.197330736889351 921 1204976
SGTC_2318 6029776 164 µM 0.850948519732358 0.182164212073293 no 614 0.19739897527641 963 818325
SGTC_3277 9138724 49.47 µM 0.850605640409565 0.18225928328612 no 615 0.197494227580356 862 15943418
SGTC_3145 9085516 49.47 µM 0.850284714013394 0.18234829563106 no 616 0.197583406507358 934 25236195
SGTC_1410 3909-8106 77.9 µM 0.847015704044555 0.183256537166535 no 617 0.198493184139892 981 1039210
SGTC_2985 9022375 71.43 µM 0.845978565532135 0.183545277818978 no 618 0.198782350893588 991 4939335
SGTC_1063 disulfiram 1.84 µM 0.841461455587868 0.184806150746952 no 619 0.200044734759073 997 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.837320627025478 0.185966708922214 no 620 0.201206183916742 988 688667
SGTC_3110 9122132 49.47 µM 0.836260170912622 0.18626465032296 no 621 0.201504277285839 1012 918317
SGTC_762 1165-0429 115 µM 0.83590000686556 0.186365907786061 no 622 0.201605579282515 987 5967793
SGTC_2791 5663188 71.43 µM 0.835331978466579 0.186525674063776 no 623 0.201765408496863 963 54690634
SGTC_1000 4048-0884 8.67 µM 0.82920931226683 0.188253143531453 no 624 0.20349298822584 947 13040088
SGTC_1261 0712-0010 12.7 µM 0.828886681438888 0.188344444620166 no 625 0.203584266235168 1030 2840123
SGTC_1822 st052468 42 µM 0.828618386063636 0.188420390152947 no 626 0.203660190369164 1007 2873678
SGTC_3017 9080681 49.47 µM 0.8263131594745 0.189073701505221 no 627 0.204313235244255 976 16451914
SGTC_1506 4226-2149 212 µM 0.824482888780762 0.189593400590595 no 628 0.204832617236416 1050 991114
SGTC_11 0438-0307 1.3 µM 0.823306661445368 0.189927849708239 no 629 0.205166813210692 997 4011476
SGTC_1790 st045711 43.5 µM 0.819791705409006 0.190929453690331 no 630 0.206167430187758 1017 585119
SGTC_2177 5811945 192 µM 0.816336566546759 0.191917164006597 no 631 0.207153832961715 1035 5343475
SGTC_1915 st067105 30.6 µM 0.815668003243837 0.192108644741001 no 632 0.207345022002734 1016 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2355 9061122 103.12 µM 0.813725900713051 0.192665537748593 no 633 0.207900996428359 1038 5302957
SGTC_2619 obliquin 87.91 µM 0.813434839242878 0.192749083815493 no 634 0.207984395688572 1049 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2760 etidronate 98.04 µM 0.810974653310579 0.193456137677832 no 635 0.208690113399275 1047 3305 A chelator and antioxidant.
SGTC_2795 7780010 54.55 µM 0.81062544005472 0.193556629142575 no 636 0.208790401383667 970 953673
SGTC_1705 st027868 56.3335 µM 0.810058812335154 0.193719752676186 no 637 0.208953187438283 1059 292948
SGTC_2375 9072683 200 µM 0.809191183356672 0.193969692285546 no 638 0.209202592746397 1108 16798029
SGTC_2130 NSC 7 2.4545 µM 0.808034643061728 0.19430316454003 no 639 0.209535319751417 1050 21448
SGTC_585 0kpi-0023 191 µM 0.807516030464943 0.194452812543808 no 640 0.209684621307699 1001 64601
SGTC_69 0096-0274 206.684 µM 0.807089403936746 0.194575970132816 no 641 0.209807488202686 1167 6741392
SGTC_2933 9026794 32.47 µM 0.803220097880764 0.195695118944711 no 642 0.210923765534383 1005 17586027
SGTC_1988 st071872 53.4 µM 0.801895745513879 0.196079067285872 no 643 0.211306633683284 1050 16414116
SGTC_1339 1486-1321 22.7 µM 0.801613695202221 0.196160896606424 no 644 0.211388226531601 1004 3469382
SGTC_1052 3253-3998 198 µM 0.801324579663038 0.19624479720303 no 645 0.211471882391218 1073 5450317
SGTC_902 1120-0002 2.07 µM 0.801066340855786 0.196319755843411 no 646 0.211546620427472 1062 3280475
SGTC_2290 7904846 200 µM 0.800814882045516 0.196392763139508 no 647 0.21161941109358 1036 2962154
SGTC_1147 3809-1045 12.3 µM 0.799437818711601 0.196792864567826 no 648 0.212018294373227 1032 325925
SGTC_605 1315-0399 119 µM 0.79923701709825 0.19685124805453 no 649 0.21207649573396 1064 24020461
SGTC_1009 4106-0057 9.87 µM 0.796127849218177 0.197756582874254 no 650 0.21297886434377 1088 2928005
SGTC_3074 9116018 49.47 µM 0.79489125196065 0.198117356392184 no 651 0.213338381701953 1038 17027303
SGTC_1878 temozolomide 1 mM 0.792782996838574 0.198733348997481 no 652 0.213952132289404 1028 5394 DNA alkylating agent.
SGTC_334 1502-1024 68.5 µM 0.792687577307756 0.198761256083674 no 653 0.213979934905821 1082 3296216
SGTC_1667 st014849 34.6 µM 0.790779316897137 0.199319855699842 no 654 0.214536390743778 1075 5348460
SGTC_1018 4259-0013 28.1 µM 0.7879294546209 0.200155845667561 no 655 0.215368985564433 1040 6801262
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.786733517103289 0.200507293570725 no 656 0.215718939558448 1129 6708561
SGTC_914 3820-6779 408 µM 0.78497188484842 0.201025655606817 no 657 0.216235026508591 1085 2893481
SGTC_2092 5303694 80.6725 µM 0.78344428270859 0.201475804161361 no 658 0.216683130274603 1036 1963699
SGTC_249 wiskostatin 11.211 µM 0.781890690940006 0.201934230229871 no 659 0.217139408163603 1085 2775510 A n-wasp and actin depolymerizer.
SGTC_2126 5251174 33.877 µM 0.778796232362374 0.202849185936508 no 660 0.218049878743833 1127 790722
SGTC_1390 3413-2614 145 µM 0.778523233240455 0.202930023804274 no 661 0.218130307723478 1131 3421432
SGTC_2351 9026858 72.31 µM 0.776482308465633 0.203534972136692 no 662 0.218732131350446 1040 1409300
SGTC_316 k060-0003 58.6 µM 0.775910547609977 0.203704639842602 no 663 0.218900902192969 1076 6152314
SGTC_2433 5607874 27.82 µM 0.774826002916196 0.204026705651753 no 664 0.219221240935702 1090 2252428
SGTC_2968 9090663 33.37 µM 0.7732433144653 0.204497243959316 no 665 0.219689198131494 1027 25236811
SGTC_1747 st037496 66.6 µM 0.773138652400432 0.204528383073461 no 666 0.219720164014437 1090 723305
SGTC_2702 st077768 96.8 µM 0.772110880791934 0.204834316113181 no 667 0.220024379165453 1004 6484119
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.771990059055426 0.204870298547645 no 668 0.220060157649548 1027 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2583 asiatic acid 100 µM 0.771916699560117 0.204892147884231 no 669 0.220081882947919 1101 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1498 4478-3555 97.6 µM 0.77189948795113 0.204897274377496 no 670 0.220086980316854 1062 3437919
SGTC_1927 st060202 13.8 µM 0.770959800331467 0.205177276913947 no 671 0.220365379809062 1065 688887
SGTC_3248 9135562 49.47 µM 0.767649967824128 0.206165330372648 no 672 0.221347583924119 1100 17650701
SGTC_2718 lomofungin 53.02 µM 0.767355391582101 0.206253403964907 no 673 0.221435121587515 1084 5351222 A RNA synthesis inhibitor.
SGTC_2143 5623677 140.463 µM 0.766788459995229 0.206422970205649 no 674 0.221603649338413 1079 5375313
SGTC_1490 4089-0339 670 nM 0.76653821138683 0.206497844510539 no 675 0.221678062288568 1057 742542
SGTC_1853 st056710 91.2 µM 0.765055613153975 0.20694176734605 no 676 0.222119214675252 1139 269167
SGTC_2861 9024595 19.48 µM 0.764502219356402 0.207107610376522 no 677 0.222284007310189 1037 16482810
SGTC_2889 9059656 51.95 µM 0.762626783257157 0.207670232193418 no 678 0.22284300342869 1133 3949838
SGTC_377 3970-0964 33.1 µM 0.762029010482155 0.207849750753171 no 679 0.223021344929518 1133 16481235
SGTC_3332 9141069 11.198 µM 0.759447544506823 0.208626048673573 no 680 0.223792440799209 1074 17332883
SGTC_1646 st011709 75.6 µM 0.758667927814821 0.208860830453882 no 681 0.224025613529593 1079 5757843
SGTC_1718 roemerine 11.9335 µM 0.758644491121255 0.2088678908299 no 682 0.22403262526155 1068 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1636 st007707 68.9 µM 0.75824817832885 0.208987302569026 no 683 0.224151212018867 1120 403051
SGTC_2634 4'-methoxyflavone 100 µM 0.756393222960475 0.209546747543528 no 684 0.224706735011121 1062 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_770 0389-1121 67.2 µM 0.756097645860971 0.209635973371347 no 685 0.224795326660427 1140 6753108
SGTC_1638 st008370 60.6 µM 0.755241738861412 0.209894471922496 no 686 0.225051974491123 1129 24207134
SGTC_2174 5790901 200 µM 0.7551654405326 0.209917524413722 no 687 0.225074860969469 1093 786020
SGTC_750 4073-0104 132 µM 0.754512278060538 0.210114929360916 no 688 0.22527083781445 947 22330957
SGTC_2496 diffractaic acid 79.83 µM 0.753297312167678 0.210482417811491 no 689 0.225635636809668 1105 94870 An apoptosis inducer which activates caspases.
SGTC_1140 3229-1848 2.98 µM 0.753115054814167 0.210537577372418 no 690 0.225690389220836 1120 2849525
SGTC_207 4185-0010 4.486 µM 0.752899136355234 0.21060293532798 no 691 0.225755263579416 1173 3761753
SGTC_1928 4'-methoxychalcone 40.3 µM 0.748901774561609 0.211815075231109 no 692 0.22695820533679 1153 641818
SGTC_769 0302-0231 76 µM 0.74713103177855 0.212353328356093 no 693 0.227492235075848 1143 571869 YER009W NTF2
SGTC_1074 carmofur 3.8 µM 0.745252883142934 0.21292510220229 no 694 0.228059429409593 1174 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1480 1070-0044 41.2 µM 0.742626022351717 0.213726315286247 no 695 0.228854064640622 1123 3124987
SGTC_1526 st051518 75 µM 0.742069668271691 0.213896232702425 no 696 0.229022563035773 1025 673993
SGTC_1256 0570-0116 285 µM 0.740254261109255 0.214451227255337 no 697 0.229572864326421 1123 410638
SGTC_1211 1056-0033 32.3 µM 0.738987437317698 0.214839007972282 no 698 0.229957312900135 1128 6741922
SGTC_1322 1348-1070 12 µM 0.738593216198758 0.214959763963424 no 699 0.230077022386172 1107 6758089
SGTC_1208 2323-2347 50.3 µM 0.737570601802341 0.215273190164497 no 700 0.230387712735719 1131 5412760
SGTC_10 0279-0212 42.575 µM 0.736782749900035 0.21551484360114 no 701 0.230627237511691 1174 39851 YBR002C RER2
SGTC_380 3970-0968 6 µM 0.735327265508695 0.215961689809057 no 702 0.231070103395288 1104 2891601
SGTC_2953 9074162 66.49 µM 0.734259083119325 0.216289972230424 no 703 0.231395425154824 1067 16451992
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.733397184477138 0.216555068333884 no 704 0.231658107966957 1115 390807
SGTC_3137 9097352 49.47 µM 0.732431827637937 0.216852208367561 no 705 0.231952519166122 1227 44120435
SGTC_908 3448-7491 47.7 µM 0.729240664970565 0.217836134664424 no 706 0.232927230209753 1183 1203031
SGTC_2820 7989630 71.43 µM 0.729109750757969 0.217876554150298 no 707 0.232967265265644 1040 2984098
SGTC_2645 abamectin 100 µM 0.728896714285597 0.217942337955105 no 708 0.233032422412253 1139 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2846 9008642 19.48 µM 0.727421719197941 0.218398117622755 no 709 0.233483826734757 1128 2992898
SGTC_3295 9122362 53.5725 µM 0.726763697576591 0.218601626024677 no 710 0.233685362597612 1147 4730473
SGTC_2189 6047310 154.431 µM 0.726319973780665 0.218738919477153 no 711 0.233821318723651 1111 711535
SGTC_1560 lithocholic acid 53.1 µM 0.725929496178682 0.218859778959016 no 712 0.233940996568778 1096 9903 A bile acid which acts as a detergent.
SGTC_794 k038-0031 316 µM 0.7249300077648 0.219169312652934 no 713 0.23424748525642 1188 6624242
SGTC_1459 k035-0031 35.7 µM 0.723840696423102 0.219506950246156 no 714 0.234581770734628 1055 3877128 YMR208W ERG12
SGTC_645 0845-0943 5.41 µM 0.723148110209253 0.219721776153125 no 715 0.234794447208352 1124 1885106
SGTC_1505 k297-0037 20.6 µM 0.721015036763906 0.220384169246122 no 716 0.235450131642331 1160 4089396
SGTC_1229 0139-0193 12.2 µM 0.719618075568816 0.220818593596281 no 717 0.23588008986126 1190 3090752
SGTC_3300 9124615 50.48 µM 0.7189652683857 0.221021770330072 no 718 0.236081159842065 1156 24824903
SGTC_860 0443-0016 25.1 µM 0.717808345662731 0.221382108385066 no 719 0.23643773340694 1200 5337942
SGTC_107 0358-0022 2.6945 µM 0.716738044341411 0.221715766053759 no 720 0.23676787331288 1102 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1588 farnesol 29.9 µM 0.716534626747108 0.22177921229873 no 721 0.236830647165556 1159 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_517 1365-0151 113 µM 0.714644080603444 0.222369372314557 no 722 0.237414499654675 1197 768657
SGTC_2903 5923464 63.88 µM 0.714237804805146 0.222496313739774 no 723 0.237540071839141 1200 2876576
SGTC_2340 7987427 183.45 µM 0.713596229365208 0.222696858986772 no 724 0.237738444915373 1122 2239331
SGTC_429 1112-0049 25.5 µM 0.713213826617886 0.222816440377009 no 725 0.237856725834105 1126 2836170
SGTC_1625 st003711 30.1 µM 0.712247387101934 0.223118819275518 no 726 0.238155798838327 1206 24207034 YER133W GLC7
SGTC_1515 3460-0031 42.1 µM 0.711490412774325 0.223355823940209 no 727 0.23839019487032 1115 2876596
SGTC_7 0192-1582 4.227 µM 0.711182013312053 0.223452423239998 no 728 0.238485726534911 1212 252616
SGTC_2575 plumbagin 510 nM 0.7109234369585 0.223533434869825 no 729 0.238565840845597 1134 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1653 st012112 65 µM 0.710912736550274 0.223536787653501 no 730 0.238569156453865 1150 720429
SGTC_1503 4585-0012 61.3 µM 0.710148300961606 0.223776384027295 no 731 0.238806088272493 1163 2922052
SGTC_3078 9116413 49.47 µM 0.706734056858605 0.224848287878921 no 732 0.239865880519232 1143 17177322
SGTC_1010 4112-3296 15.2 µM 0.705928444414117 0.225101634161538 no 733 0.240116318754467 1214 704384
SGTC_1552 6-methylflavone 10.6 µM 0.704977489028494 0.225400895429536 no 734 0.240412122630001 1162 689013
SGTC_2276 7947513 42.08 µM 0.704724795857913 0.225480454666334 no 735 0.24049075865181 1096 2105100
SGTC_1271 0832-2808 169 µM 0.703364179597198 0.22590911131132 no 736 0.240914411818129 1197 3663794
SGTC_18 0111-0177 500 nM 0.703255905318808 0.225943242466134 no 737 0.240948142456713 1274 721752
SGTC_2380 9035439 200 µM 0.702999042249536 0.226024224726735 no 738 0.241028173170371 1254 6462575
SGTC_935 2996-0153 430 µM 0.702764272991077 0.226098255731271 no 739 0.241101332766726 1195 23738523
SGTC_2805 7950783 58.44 µM 0.701912949050364 0.226366823031122 no 740 0.241366726472138 1178 1178958 YDL195W SEC31
SGTC_633 0437-0093 97.7 µM 0.70185510872214 0.226385076463043 no 741 0.241384763506779 1204 2831118
SGTC_2662 daunorubicin 22.37 µM 0.700542401164006 0.226799568281901 no 742 0.241794317483064 1160 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3103 9120822 49.47 µM 0.700426425783987 0.226836208470691 no 743 0.241830518969766 1249 17141819
SGTC_432 NS 1619 61.3 µM 0.699583471987343 0.227102623816015 no 744 0.242093733692601 1177 4552 A K+/calcium channel activator.
SGTC_799 1310-0557 151 µM 0.699424231872934 0.227152971417695 no 745 0.242143474310627 1200 5354492
SGTC_3135 9127742 49.47 µM 0.697339776556411 0.227812602159618 no 746 0.242795090370451 1162 3643468
SGTC_2315 7733312 200 µM 0.696821173587569 0.227976882576459 no 747 0.242957356776199 1178 726316
SGTC_1236 0330-0013 258 µM 0.695654439995394 0.228346718019627 no 748 0.243322632040328 1185 4617066
SGTC_1926 methyl fluorone black 53.6 µM 0.695018443518881 0.22854846039677 no 749 0.243521871635775 1061 72721 Reacts with homocysteine.
SGTC_1891 st059073 26.2 µM 0.692717932729212 0.229279033373736 no 750 0.244243291483536 1249 688754
SGTC_1113 artemisinin 1.17947 µM 0.690644838762195 0.229938505688951 no 751 0.244894381068538 1215 2240 An anti-malaria and mitochondrial poison.
SGTC_2967 9089538 49.85 µM 0.688251687493939 0.230701109973768 no 752 0.245647149901967 1219 728216
SGTC_1062 mesoridazine 14.2 µM 0.685338044863592 0.231631478930887 no 753 0.246565314822227 1215 4078 A neuroleptic.
SGTC_1787 fluconazole 80 µM 0.684640059376905 0.231854666027708 no 754 0.246785540926459 1143 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1760 st045453 10.4495 µM 0.680541456511166 0.233167644870662 no 755 0.248080840724642 1236 3323419 YIL048W NEO1
SGTC_947 3447-0010 211 µM 0.6799032617425 0.233372459969875 no 756 0.248282858107115 1239 748350
SGTC_1212 0520-0165 585 µM 0.679777763068568 0.233412747853567 no 757 0.248322594405919 1344 5403258
SGTC_2248 tofa 1.1 µM 0.679605373966141 0.233468094904176 no 758 0.248377183018337 1171 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1116 jasmonic acid 1.58368 µM 0.678070067793288 0.233961339561603 no 759 0.24886363402434 1262 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_635 k038-0028 24.7 µM 0.677573582549986 0.234120967794734 no 760 0.249021050343398 1247 4035102
SGTC_2376 9072922 81.32 µM 0.677008756345873 0.234302642090509 no 761 0.249200199345935 1251 17087968
SGTC_919 tnp00227 403.569 nM 0.676488213314963 0.234470141934644 no 762 0.249365363485011 1236 1269246 A methoxyflavone. YNL221C POP1
SGTC_973 1325-0077 65.9 µM 0.674684245614514 0.23505113325942 no 763 0.249938197966761 1262 2835149
SGTC_1050 3232-1156 69.3 µM 0.674465263342378 0.235121713444869 no 764 0.250007781412704 1196 700529
SGTC_743 1275-0778 158 µM 0.674392481159358 0.235145174464929 no 765 0.250030910835042 1229 2849257 YMR203W TOM40
SGTC_1867 st057372 64 µM 0.67349663970615 0.235434050929219 no 766 0.25031569291642 1234 688837
SGTC_3038 9091290 49.47 µM 0.672003328855054 0.235916024702143 no 767 0.250790788554367 1257 25236843
SGTC_2447 5741742 33.78 µM 0.671094640754565 0.236209574412013 no 768 0.251080120416138 1268 1776504
SGTC_625 k213-0058 121 µM 0.6701505512891 0.236514773414457 no 769 0.251380911228502 1296 3655420
SGTC_1299 1079-1439 3.74 µM 0.669895210325571 0.236597355621719 no 770 0.25146229662875 1211 323161
SGTC_1160 4092-0570 10.5 µM 0.66944592206952 0.236742702644153 no 771 0.251605533085154 1234 4994975
SGTC_673 1082-0474 110 µM 0.666431786466424 0.237719059451408 no 772 0.252567575432555 1265 3098046
SGTC_87 0100-0052 35.5 µM 0.664461957688377 0.23835832975263 no 773 0.253197344700025 1306 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2826 7992541 19.48 µM 0.664124060557606 0.238468082335013 no 774 0.25330545590418 1308 2985066
SGTC_963 1269-2853 151 µM 0.664027402072657 0.238499483127758 no 775 0.25333638654084 1230 3668223
SGTC_2346 9031566 143.75 µM 0.663969507476647 0.238518292040161 no 776 0.253354913715222 1214 4771086
SGTC_2238 6671620 73.2395 µM 0.662268007322503 0.239071441284487 no 777 0.253899738223983 1218 729941
SGTC_1555 citronellol 128 µM 0.662208898934437 0.239090669722415 no 778 0.253918675919863 1230 8842 A terpine precursor.
SGTC_3127 9126946 49.47 µM 0.661823390003764 0.239216099636865 no 779 0.254042207043151 1197 27243249
SGTC_2369 9071472 200 µM 0.661536775972364 0.239309376217834 no 780 0.254134069063376 1278 17296037
SGTC_849 0386-0493 241 µM 0.661437547452041 0.239341674092252 no 781 0.254165876633327 1220 726119
SGTC_2 0422-0095 29 µM 0.658891944190119 0.24017105558168 no 782 0.254982579636555 1142 6790840
SGTC_1048 3161-0300 24.5 µM 0.65773221220117 0.240549425914878 no 783 0.255355109890173 1263 2165101
SGTC_2024 5144227 134 µM 0.657562297110388 0.240604889098729 no 784 0.255409714065806 1249 3475211
SGTC_12 0849-0099 9.267 µM 0.655435281120006 0.241299772093491 no 785 0.256093771144456 1203 6071388
SGTC_2504 purpurogallin 52.29 µM 0.654817377343756 0.241501841665861 no 786 0.25629267050036 1232 5281571 An antioxidant.
SGTC_931 2812-0076 566 µM 0.653200909065917 0.242030900539706 no 787 0.256813382131687 1286 3450959
SGTC_1030 k029-0042 36.7 µM 0.651183164938959 0.242692175232277 no 788 0.257464128224848 1297 6080581
SGTC_2852 9023854 51.95 µM 0.643406494886378 0.245249945359395 no 789 0.25998018508266 1340 19798528
SGTC_3216 9129716 49.47 µM 0.642895938391683 0.245418374413787 no 790 0.260145812536719 1234 8056934
SGTC_244 nsc-207895 1.295 µM 0.642259322037482 0.245628476788145 no 791 0.260352410697823 1182 42640
SGTC_1 0258-0098 57.368 µM 0.641265838495619 0.245956548885964 no 792 0.260674990106355 1204 6790032 YDR047W HEM12
SGTC_527 4476-4215 268 µM 0.640730366998881 0.246133471888435 no 793 0.260848940443016 1285 4418754
SGTC_2689 tacrolimus 100 µM 0.640291880383948 0.246278401319024 no 794 0.260991429257099 1295 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1159 4092-0538 61.2 µM 0.639278825410589 0.246613413055482 no 795 0.261320780425705 1316 717301
SGTC_838 0109-0203 71.4 µM 0.638753194123911 0.246787332578961 no 796 0.261491750873329 1282 759422
SGTC_2700 st077718 96.8 µM 0.638629565173396 0.246828248143439 no 797 0.26153197161692 1272 904970
SGTC_2412 st077135 33.4 µM 0.638260464321348 0.246950425353521 no 798 0.261652071693111 1353 13258915
SGTC_1839 st053978 48 µM 0.638141163296494 0.246989922472789 no 799 0.261690896571887 1326 3788398
SGTC_1096 rimcazole 32.2 µM 0.638087889236377 0.247007561065116 no 800 0.261708234837224 1224 18528119 A dopamine reuptake inhibitor.
SGTC_452 diindolylmethane 8 µM 0.638070371334731 0.247013361241958 no 801 0.261713936240241 1282 3071 Inhibits expression of several cancer promoting factors.
SGTC_1571 st070080 73.4 µM 0.637235899121187 0.247289739366287 no 802 0.261985598644488 1344 4315245
SGTC_2058 5236698 133 µM 0.636123171512165 0.247658533042547 no 803 0.262348071868316 1278 766665
SGTC_210 3551-0445 56.827 µM 0.634307614270804 0.248260897129077 no 804 0.262940044146738 1328 2865180 YOR207C RET1
SGTC_1780 st038448 24.544 µM 0.633872080284796 0.24840551432599 no 805 0.263082153851371 1369 728868 YDL195W SEC31
SGTC_2407 paclitaxel 400 µM 0.632834396600184 0.248750253603192 no 806 0.263420896123641 1422 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_835 0312-0010 67.2 µM 0.630794011886404 0.249428852469124 no 807 0.264087609626356 1264 1626196
SGTC_2779 methotrexate 400 µM 0.630512055760767 0.249522703818195 no 808 0.26417980881368 1339 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2356 9061756 188.97 µM 0.630151865195751 0.249642623414764 no 809 0.264297614378776 1282 20104043
SGTC_3347 9188721 44.724 µM 0.629534162513517 0.249848348730077 no 810 0.264499705277756 1288 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2244 6635614 200 µM 0.629507023088914 0.249857389554199 no 811 0.264508586159358 1263 836499
SGTC_60 0986-0278 202 µM 0.62911358222022 0.249988474096647 no 812 0.26463734954764 1124 3110598
SGTC_2635 hydroquinidine 100 µM 0.627592488878504 0.250495606996658 no 813 0.265135465207532 1326 442912 An experimental heart treatment.
SGTC_2902 5787006 60.46 µM 0.626430577562549 0.25088335546327 no 814 0.265516279302217 1291 591003
SGTC_490 phenamil 164 µM 0.625977106613313 0.251034772149235 no 815 0.265664978735773 1267 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1842 st055362 61.2 µM 0.622707804585114 0.252127841147817 no 816 0.266738276529823 1310 676032
SGTC_1795 st049545 62.3 µM 0.622516309187436 0.252191944079343 no 817 0.266801211523954 1283 5291882
SGTC_726 3448-4391 34.2 µM 0.619281759069624 0.253276004578711 no 818 0.267865379493715 1403 1356692
SGTC_384 k007-0144 5.16 µM 0.618846923275922 0.253421926530384 no 819 0.268008603460561 1328 6824886
SGTC_2296 7971656 126.45 µM 0.618639897016681 0.253491415808731 no 820 0.268076806245804 1312 666570
SGTC_3069 9117009 49.47 µM 0.614603429426831 0.254848272082272 no 821 0.269408324530811 1217 41904981
SGTC_1840 st055363 71 µM 0.612933119882786 0.255410855660714 no 822 0.269960281390675 1261 676033
SGTC_991 3996-0057 64.7 µM 0.612166533757805 0.255669269683328 no 823 0.270213790526131 1331 715343
SGTC_995 3931-2021 34.6 µM 0.61208987453808 0.255695118797403 no 824 0.270239148186765 1333 730143
SGTC_324 1315-0088 19.6 µM 0.611549626719973 0.255877326409041 no 825 0.270417887378202 1270 6787421
SGTC_3065 9113888 49.47 µM 0.609840776304643 0.256454110629978 no 826 0.270983643569292 1394 16648368
SGTC_704 1310-0270 142 µM 0.608632047443794 0.256862498669311 no 827 0.271384178701653 1290 5718033
SGTC_2370 9071495 200 µM 0.606673063155327 0.257525090315119 no 828 0.272033950972974 1287 21791103
SGTC_3356 9151811 4.48 µM 0.60649251489355 0.257586202208635 no 829 0.272093875641347 1310 1859254 YPR165W RHO1
SGTC_559 1550-0661 158 µM 0.60642125853599 0.257610323100669 no 830 0.272117527708875 1369 5830875
SGTC_2788 5282734 71.43 µM 0.605037337483068 0.25807902482146 no 831 0.27257709414594 1425 743706
SGTC_2252 omeprazole 400 µM 0.60427698508079 0.258336726513301 no 832 0.272829752531899 1297 4594 A proton pump inhibitor.
SGTC_1383 3049-0032 20.7 µM 0.603350421713149 0.258650941249796 no 833 0.273137798305615 1371 712864
SGTC_2140 5586273 200 µM 0.602902655382959 0.258802857956878 no 834 0.273286724696456 1333 854421
SGTC_1106 tegaserod maleate 11.7 µM 0.600259814525074 0.259700452055973 no 835 0.27416654790691 1363 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2879 9041815 71.43 µM 0.600172361513131 0.25973018136335 no 836 0.274195685623369 1292 4942971
SGTC_286 k060-0067 22.9 µM 0.60012772232335 0.259745356957357 no 837 0.274210559160436 1300 5985051
SGTC_1361 1608-0041 5.61 µM 0.598969473806849 0.260139276460865 no 838 0.274596620556414 1320 X1361
SGTC_356 1634-0012 32.5 µM 0.598779307119152 0.260203981435205 no 839 0.274660031546351 1350 735457
SGTC_115 0527-0192 112.043 µM 0.598497826258379 0.260299771644156 no 840 0.274753904456994 1356 4233931
SGTC_676 falcarinol 140 µM 0.597679384978951 0.260578396998729 no 841 0.275026941673839 1436 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_492 tmb-8 126 µM 0.597105457463565 0.260773873063639 no 842 0.275218487238145 1257 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_868 0527-0199 213 µM 0.597010294337194 0.260806292310409 no 843 0.275250253823162 1352 2849450
SGTC_1340 1486-1359 257 µM 0.596418081648199 0.261008088151129 no 844 0.275447982028748 1347 4309068
SGTC_969 1313-0238 134 µM 0.596361879976721 0.261027242980569 no 845 0.27546675029466 1361 5212874
SGTC_2545 solidagenone 89.61 µM 0.595834249858915 0.261207106763161 no 846 0.275642980391851 1235 6708572 An anti ulcer agent
SGTC_2796 7949634 45.45 µM 0.595574528213746 0.261295666635328 no 847 0.275729748580775 1314 2971588
SGTC_610 4215-0184 155 µM 0.595474122972086 0.261329906942723 no 848 0.275763295709205 1379 5605015
SGTC_203 k066-0004 30.888 µM 0.595155551607405 0.26143856175992 no 849 0.275869749191223 1405 6795412
SGTC_3212 9128307 49.47 µM 0.595134229638538 0.261445834850748 no 850 0.275876874839367 1294 27243542
SGTC_262 fenpropimorph 62.5 µM 0.594401046697787 0.261695992498829 no 851 0.276121954285882 1303 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1129 3453-1384 223 µM 0.594214762445214 0.261759571136331 no 852 0.276184240135678 1427 1084452
SGTC_1847 st056231 15 µM 0.592667606250457 0.262287920107403 no 853 0.276701812315976 1361 5393180
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.592425759042611 0.262370559508574 no 854 0.276782760709438 1373 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_725 1497-0963 19 µM 0.591828958986784 0.262574543639206 no 855 0.276982564571356 1397 3549977
SGTC_3227 9130768 49.47 µM 0.59095658736621 0.262872863112095 no 856 0.277274754562007 1381 17720899
SGTC_368 fentichlor 4.58 µM 0.590145699637113 0.263150312653961 no 857 0.277546486411287 1319 7329 A pesticide.
SGTC_2052 5265182 7.135 µM 0.589809930428736 0.26326524165707 no 858 0.277659042154791 1405 1239884
SGTC_450 aminopyrene 156 nM 0.588977104419019 0.263550416711665 no 859 0.277938316282826 1358 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1813 st051246 8.6015 µM 0.587308156620024 0.26412236944205 no 860 0.278498382017576 1332 5291959
SGTC_2915 7971052 15.16 µM 0.586742233591097 0.264316456189294 no 861 0.278688419294236 1230 5741558
SGTC_851 0394-0702 453 µM 0.58469998219183 0.265017462056373 no 862 0.279374733020363 1361 762646
SGTC_626 0214-0009 33 µM 0.584610413285711 0.26504822832631 no 863 0.279404852100011 1436 3437874
SGTC_3338 9144300 39.5675 µM 0.584408330404688 0.265117648995378 no 864 0.279472811724963 1376 4901274
SGTC_2675 theaflavin digallate 100 µM 0.581914854663029 0.265974981365476 no 865 0.280312017107238 1367 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2692 st077426 47.7 µM 0.581481261323252 0.266124207091827 no 866 0.280458071957224 1360 25238571
SGTC_730 1436-0052 41.2 µM 0.580946825407592 0.266308197169046 no 867 0.28063814605207 1367 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_967 1306-0166 352 µM 0.579072850692483 0.266953858055481 no 868 0.281270009074387 1377 4437607
SGTC_1499 4480-0877 67.3 µM 0.577887692494586 0.267362601254249 no 869 0.281669972561425 1330 2861909
SGTC_1977 st070720 65.3 µM 0.57761159605942 0.267457868075734 no 870 0.281763188092143 1365 682188
SGTC_1739 st037196 92.5 µM 0.57725918997467 0.267579490337731 no 871 0.281882188843535 1409 612214
SGTC_364 0083-0097 67.7 µM 0.576361713383203 0.267889353006837 no 872 0.282185358731249 1411 5207356
SGTC_1848 st056003 16.4 µM 0.573587961181812 0.268848159413403 no 873 0.283123330159586 1411 146492
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.572797604013614 0.269121678315336 no 874 0.283390870783857 1324 6708514
SGTC_1017 4239-0030 168 µM 0.572633094515473 0.269178627667743 no 875 0.283446573468187 1338 1149593
SGTC_2515 chrysin 20.77 µM 0.572629922800846 0.269179725700794 no 876 0.283447647457857 1436 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_564 3555-0129 330 µM 0.572510834338889 0.269220955205972 no 877 0.283487973990958 1305 563260
SGTC_2165 5727197 32.143 µM 0.572391749684912 0.269262186560103 no 878 0.283528301983978 1488 1361712
SGTC_964 1287-0107 19.4 µM 0.571076640076379 0.269717734917767 no 879 0.283973846300162 1455 51516812 YPR165W RHO1
SGTC_2139 5578692 56.4705 µM 0.570397599701778 0.269953102625532 no 880 0.28420402860196 1367 650991 YMR113W FOL3
SGTC_385 1494-0393 12.4 µM 0.570397555713988 0.269953117875827 no 881 0.284204043515908 1401 3090647
SGTC_2921 7974240 10.71 µM 0.569791355829585 0.270163324566197 no 882 0.284409609564398 1427 2979074 YDR527W RBA50
SGTC_511 blebbistatin 171 µM 0.569245909942336 0.270352534064702 no 883 0.284594634263296 1447 3476986 A myosin inhibitor.
SGTC_2395 5646831 180.19 µM 0.568953606426468 0.270453958363795 no 884 0.284693812330919 1439 6808628
SGTC_2617 dihydrotanshinone i 20.83 µM 0.567775109638914 0.270863069275501 no 885 0.285093841474088 1387 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_843 0310-0051 143 µM 0.567136357261715 0.27108493885624 no 886 0.285310771602696 1398 2065037
SGTC_1709 st033179 39.1045 µM 0.566673174864387 0.27124588116852 no 887 0.285468124632271 1369 573381
SGTC_3104 9120930 49.47 µM 0.56575590165906 0.27156474723205 no 888 0.285779863960772 1377 17014836
SGTC_3040 9091894 49.47 µM 0.565426409219602 0.271679332222682 no 889 0.28589188292656 1336 25236966
SGTC_2082 5219693 150 µM 0.565124433071449 0.271784369222685 no 890 0.285994565390084 1366 2834649
SGTC_1385 3091-4834 14.1 µM 0.564352119104617 0.27205309672185 no 891 0.286257258889146 1407 4072814
SGTC_1057 3448-5381 134 µM 0.564010622353523 0.272171963005195 no 892 0.286373451507759 1443 5497911
SGTC_1624 st003710 6.25 µM 0.563064338504801 0.272501475020337 no 893 0.286695536921669 1469 24207033
SGTC_2923 7992654 58.14 µM 0.562981400343574 0.272530364927394 no 894 0.286723774661511 1406 2985126
SGTC_776 4476-4378 112 µM 0.562436711491529 0.272720134551238 no 895 0.286909256215093 1391 2892008
SGTC_733 4069-0007 56.1 µM 0.5617208257718 0.272969648851226 no 896 0.287153121442504 1427 5717425 YNL287W SEC21
SGTC_2282 7944268 200 µM 0.561604270560179 0.273010283633485 no 897 0.287192835059952 1463 2970414
SGTC_1626 st003712 1.76 µM 0.560774061148464 0.273299807252626 no 898 0.287475785788785 1400 24207035
SGTC_1798 st045719 60.953 µM 0.560283813782849 0.273470845372729 no 899 0.287642933046495 1342 3980186
SGTC_3024 9090631 49.47 µM 0.559091888545411 0.273886906652704 no 900 0.288049505156711 1365 25236383
SGTC_3096 9117468 49.47 µM 0.55879619316979 0.273990172456886 no 901 0.288150410414193 1323 41316311
SGTC_1621 st003705 32.4 µM 0.557019163803324 0.274611170079501 no 902 0.288757167935873 1460 24207032
SGTC_2441 5730946 39.09 µM 0.556929080392618 0.274642668952643 no 903 0.288787942466094 1455 1774275
SGTC_1721 st082152 9.2685 µM 0.555111662442519 0.275278533883539 no 904 0.289409143098315 1341 5296051
SGTC_1608 st001473 40.5 µM 0.555089921235362 0.275286144922401 no 905 0.289416578126936 1360 7292267
SGTC_2493 resveratrol 26.09 µM 0.554909410705528 0.27534934102766 no 906 0.28947831233879 1356 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_256 clotrimazole 625 nM 0.554858233178105 0.275367259399939 no 907 0.289495816068018 1385 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2844 9010103 25.97 µM 0.55399786607917 0.275668578625152 no 908 0.289790153068705 1398 2480525
SGTC_2203 7227154 166.4 µM 0.552821426163203 0.276080855581778 no 909 0.290192847663474 1397 896304
SGTC_1765 st044815 90.4 µM 0.551736086173964 0.276461475334485 no 910 0.290564591160178 1345 645695
SGTC_1844 rapamycin 4 nM 0.550494690161795 0.276897137876328 no 911 0.290990058921326 1402 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1310 1188-0297 994 nM 0.55029358120853 0.276967747820836 no 912 0.291059013046475 1384 1588352
SGTC_801 0866-0028 10.1 µM 0.549540208217994 0.277232337628855 no 913 0.291317389488538 1413 6849771
SGTC_1012 4112-3522 18 µM 0.549231367558606 0.277340840326881 no 914 0.291423340260475 1429 3112398
SGTC_1314 1222-0010 41.1 µM 0.548594034751625 0.2775648153538 no 915 0.291642040245082 1421 3526027
SGTC_1275 0867-0008 21.1 µM 0.543784578050747 0.279257825502193 no 916 0.29329486126498 1436 3422836
SGTC_2424 5537928 59.2 µM 0.543151998517205 0.279480877088166 no 917 0.293512576625138 1404 5382802
SGTC_2854 9024559 71.43 µM 0.542121624217145 0.279844378778518 no 918 0.293867361455616 1376 3163529
SGTC_1568 digitonin 820 nM 0.541247336980408 0.280152994863846 no 919 0.29416855690088 1549 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_84 0443-0269 128.823 µM 0.541183288348152 0.280175609977301 no 920 0.294190627516926 1383 6150058
SGTC_3344 9148862 3.898 µM 0.541109367162993 0.280201712118015 no 921 0.294216101082054 1491 4905352
SGTC_2398 5228213 48.84 µM 0.540331072970985 0.280476605280904 no 922 0.294484366501711 1494 80771 YMR134W ERG29
SGTC_1242 0402-0103 60.1 µM 0.540037217110378 0.280580428978056 no 923 0.294585683215035 1386 432868
SGTC_2661 dactinomycin 12.96 µM 0.539933987954591 0.28061690580549 no 924 0.294621278762951 1420 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1678 st019265 80.2 µM 0.53975458150613 0.280680305931776 no 925 0.294683146537156 1544 5367020
SGTC_487 nimodipine 119 µM 0.535529955354162 0.282175238218258 no 926 0.296141724708337 1394 4497 L-type voltage-gated calcium channels inhibitor
SGTC_212 3807-4682 38.772 µM 0.53545804733405 0.282200716831306 no 927 0.296166580041849 1539 3125501 YBL034C STU1
SGTC_1645 Cervolide 78 µM 0.535088167672289 0.28233179092706 no 928 0.296294445746046 1388 23173 A fragrance.
SGTC_628 1636-0253 16 µM 0.534893772571411 0.282400690374968 no 929 0.296361657388752 1484 4456143
SGTC_1029 k015-0030 64.7 µM 0.534850197834008 0.282416135676966 no 930 0.296376724209301 1463 2208316
SGTC_424 splitomicin 100 mM 0.534299757030973 0.282611277379903 no 931 0.296567080146218 1393 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1020 4335-0961 93.3 µM 0.534224526984139 0.282637952891609 no 932 0.296593100892625 1365 669075
SGTC_612 0302-0167 22.4 µM 0.53198477240491 0.28343269204608 no 933 0.297368271085859 1522 235821
SGTC_2607 solasodine 47.35 µM 0.531857825333169 0.283477769133942 no 934 0.297412234666298 1432 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1751 st044839 27.194 µM 0.529169579999695 0.284433132441972 no 935 0.298343908531536 1461 5291326
SGTC_2946 9065502 71.43 µM 0.528304220264232 0.284740995672049 no 936 0.298644101467902 1329 16489101
SGTC_537 1334-0398 209 µM 0.527687764704332 0.284960404888983 no 937 0.298858033382183 1523 5846986
SGTC_2558 carylophyllene oxide 100 µM 0.526842478058696 0.285261390816376 no 938 0.299151490929703 1487 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2354 9060492 162 µM 0.526273865994179 0.285463944861243 no 939 0.299348969114145 1530 6471895
SGTC_2713 st079149 53.4 µM 0.523453330012713 0.286469702325445 no 940 0.300329410180969 1473 3103253
SGTC_982 1491-0518 27.5 µM 0.52262603450521 0.286765021108769 no 941 0.300617259788405 1435 3091256
SGTC_1814 st052110 31.539 µM 0.521051764960001 0.28732738466456 no 942 0.301165355613995 1508 674163
SGTC_506 n9-isopropylolomoucine 153 µM 0.520582089544457 0.287495264009531 no 943 0.30132896440789 1560 6610355
SGTC_1004 4084-0029 199 µM 0.518055178656449 0.288399270426035 no 944 0.302209885621395 1507 716894 YLR208W SEC13
SGTC_535 2293-4129 48.2 µM 0.517033500334072 0.288765157524264 no 945 0.302566386723548 1559 396118 YIL048W NEO1
SGTC_3021 9087658 49.47 µM 0.51414911355953 0.289799302176751 no 946 0.303573870926514 1462 25237042
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.514121443831492 0.289809231065207 no 947 0.303583542905004 1521 5377381
SGTC_1368 1852-0141 284 µM 0.51368150285434 0.289967119065671 no 948 0.303737343153654 1442 2838987
SGTC_103 0844-0104 51.839 µM 0.512889103119705 0.290251600751254 no 949 0.304014448162133 1495 5375804
SGTC_1898 st060199 18.6 µM 0.51224801246169 0.290481856164272 no 950 0.3042387222858 1447 688866
SGTC_108 0509-0257 621.132 µM 0.512101215822663 0.29053459196808 no 951 0.304290086837015 1431 536624
SGTC_1610 st001799 48.1 µM 0.511590827082472 0.290717980892219 no 952 0.304468703320151 1415 621897
SGTC_699 0375-0592 111 µM 0.51088292045139 0.290972429990266 no 953 0.304716520696403 1496 762578
SGTC_1742 st038235 28.8875 µM 0.510746675965566 0.291021413480898 no 954 0.304764226189422 1484 564103 YBR002C RER2
SGTC_3008 9078912 71.4286 µM 0.510603424398187 0.291072920356655 no 955 0.304814388765881 1453 16648731
SGTC_2667 digitoxin 100 µM 0.510357642407742 0.291161302519211 no 956 0.304900463093941 1466 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1899 st063254 59.6 µM 0.510253568902812 0.291198730686869 no 957 0.304936913514215 1391 3093813
SGTC_2958 9077254 16.72 µM 0.508147209933119 0.291956727221812 no 958 0.305675054571366 1466 16457351
SGTC_410 α-linolenic acid 100 µM 0.503722249079999 0.293552083441627 no 959 0.307228285631506 1512 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_85 0868-0259 160.055 µM 0.502359614234216 0.294044173609321 no 960 0.307707291002638 1505 83173
SGTC_1152 3909-8331 15.9 µM 0.502323684326272 0.294057154184001 no 961 0.307719925840894 1462 16001939
SGTC_2642 cholecalciferol 100 µM 0.499886279070992 0.294938345340978 no 962 0.30857757706022 1508 9821465 A vitamin D precursor, similar to steriods.
SGTC_1157 4092-0394 27.6 µM 0.498357432028939 0.295491687164289 no 963 0.309116067230936 1580 3659885
SGTC_1818 st052136 56.3 µM 0.496754688735655 0.296072286627401 no 964 0.30968102578228 1423 674169
SGTC_382 3229-0966 23.2 µM 0.496722159854766 0.296084075749331 no 965 0.309692496703839 1564 5722370
SGTC_2223 6903751 107.57 µM 0.496043123363982 0.296330221427398 no 966 0.309931993120967 1493 5598863
SGTC_2164 5685496 200 µM 0.495568257082846 0.296502412653764 no 967 0.31009952657711 1512 759046
SGTC_3302 9125395 16.351 µM 0.495491057943616 0.296530410160022 no 968 0.31012676626308 1523 17599668
SGTC_2821 7996764 71.43 µM 0.495019503184668 0.296701453349035 no 969 0.310293176791213 1543 2987135
SGTC_3329 9141233 27.5565 µM 0.494091305063743 0.297038262952244 no 970 0.310620849122204 1578 4909101 YNL103W MET4
SGTC_2838 9002687 71.43 µM 0.493974142252473 0.297080789534937 no 971 0.310662220604794 1451 6457060
SGTC_2120 5538279 151.968 µM 0.49323403879336 0.297349489187254 no 972 0.310923614628027 1524 2058197
SGTC_2886 9058944 51.95 µM 0.491742057055191 0.297891500645927 no 973 0.311450851383338 1423 4949929
SGTC_2084 5306078 60.6385 µM 0.491076346823609 0.298133487045233 no 974 0.311686225077501 1519 679340
SGTC_1405 3909-7894 12 µM 0.490248857809593 0.298434404981194 no 975 0.311978905814912 1571 7104060
SGTC_549 1661-1316 519 µM 0.490030341891686 0.298513891767803 no 976 0.312056214160573 1580 2857282
SGTC_887 0885-0007 9.62 µM 0.489047099725145 0.298871672509954 no 977 0.312404175994437 1566 5719458
SGTC_2390 9097792 176.6 µM 0.48884765022058 0.298944271669863 no 978 0.312474780064478 1441 4497149
SGTC_406 estrone 100 µM 0.487961375954402 0.299266970294495 no 979 0.312788599701309 1607 5870 A steroid.
SGTC_327 1273-0057 3.96 µM 0.487571695604175 0.299408905621538 no 980 0.312926624056092 1466 3108138
SGTC_2250 alverine citrate 130 µM 0.486754278140015 0.299706737016893 no 981 0.313216237619409 1471 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2201 6605497 169.863 µM 0.485452091678838 0.300181474115653 no 982 0.313677844344194 1546 670741
SGTC_2328 6201408 200 µM 0.484116338372213 0.300668801625788 no 983 0.314151653316604 1478 2890418
SGTC_2677 mitomycin C 100 µM 0.483075724466392 0.301048699678906 no 984 0.31452098495279 1509 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1762 st045503 25.4615 µM 0.480736506452678 0.301903469304616 no 985 0.31535189081842 1505 4645554
SGTC_958 1222-0007 33 µM 0.480731068904682 0.301905457499474 no 986 0.31535382336229 1595 7312461
SGTC_826 1683-5028 118 µM 0.478225461311773 0.302822237533369 no 987 0.316244871184157 1521 722377
SGTC_236 1509-0011 5.31 µM 0.478035359934623 0.302891844825264 no 988 0.316312518969335 1533 3107280
SGTC_348 k064-0012 10.7 µM 0.476205270084781 0.303562314366192 no 989 0.316964072660265 1477 5066323
SGTC_1882 5615643 20 µM 0.475889385754242 0.303678108410211 no 990 0.317076592216344 1460 2253075
SGTC_2483 5729050 27.16 µM 0.475853627232286 0.303691217690518 no 991 0.317089330644177 1654 2865180
SGTC_101 0490-5701 117.494 µM 0.475024229172767 0.303995350641932 no 992 0.317384851840777 1570 4661669
SGTC_2911 7942208 15.64 µM 0.473297542009706 0.304628946754016 no 993 0.318000457758466 1488 1243384
SGTC_2236 dapsone 200 µM 0.471339036408526 0.305348317066528 no 994 0.318699321697567 1533 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1449 4112-4002 201 µM 0.471027283044241 0.305462895344332 no 995 0.318810625904394 1455 2059539
SGTC_1975 st070967 30.8 µM 0.470596610752039 0.305621211076519 no 996 0.318964414203276 1605 261391
SGTC_2435 5706476 10.6 µM 0.469890126299156 0.305880994446393 no 997 0.319216759464451 1593 5725375
SGTC_3 0833-0587 95.581 µM 0.468147881576658 0.306522057454318 no 998 0.319839420063994 1503 5382644
SGTC_3171 9103192 49.47 µM 0.466599474437187 0.307092294882172 no 999 0.320393231544441 1577 13018434
SGTC_1866 st057638 64 µM 0.464627294071148 0.307819272764744 no 1000 0.321099191434236 1534 688802
SGTC_878 0828-0289 13.7 µM 0.464546323128854 0.307849136131124 no 1001 0.321128189564911 1518 745350 YLR208W SEC13
SGTC_741 4582-0002 126 µM 0.463394159889635 0.308274210022463 no 1002 0.321540932003406 1492 2912688
SGTC_1774 st048371 48.465 µM 0.463346349901093 0.308291854385299 no 1003 0.321558063866237 1488 4242727
SGTC_288 1315-0019 35.1 µM 0.463159761339499 0.308360719468888 no 1004 0.321624928203945 1536 6811474
SGTC_2015 5119600 184 µM 0.462030712670851 0.308777566365693 no 1005 0.322029647981099 1644 2828786
SGTC_1207 2099-0101 141 µM 0.461238293021558 0.309070276434141 no 1006 0.32231382556859 1619 5837381
SGTC_3308 9128332 17.569 µM 0.460048752816224 0.309509905564727 no 1007 0.322740613534145 1657 17332805 YDL196W YDL196W
SGTC_1164 k060-0068 93.7 µM 0.457702967606282 0.310377657440896 no 1008 0.32358292783828 1560 5963676
SGTC_1213 1315-0166 115 µM 0.454636676342507 0.311513531499951 no 1009 0.324685322167494 1484 768401
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.454559904409557 0.311541993916111 no 1010 0.324712943013585 1666 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_144 4161-2749 112.381 µM 0.453113484013682 0.312078449953022 no 1011 0.325233513144069 1472 797501 YMR168C CEP3
SGTC_2159 5658611 73.75 µM 0.452797951302021 0.312195529414879 no 1012 0.325347119491613 1571 793844
SGTC_3019 9081971 49.47 µM 0.451408338633373 0.312711375415887 no 1013 0.325847637264096 1661 16451803
SGTC_237 nikkomycin 200 µM 0.449545836838528 0.313403340846628 no 1014 0.326518975080352 1630 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_841 0251-0215 91.2 µM 0.449068529071958 0.313580778382969 no 1015 0.326691111015044 1587 3888614
SGTC_2813 7971799 71.43 µM 0.448930772045928 0.313631997112276 no 1016 0.326740798474452 1587 2234054
SGTC_619 1652-1634 108 µM 0.448065633311526 0.313953741984299 no 1017 0.327052914814677 1549 5400454
SGTC_3060 1327-0027 12.5 µM 0.447152815259443 0.314293372193231 no 1018 0.327382363631228 1623 16000455 YPR107C YTH1
SGTC_151 3013-0144 2.285 µM 0.446733857269613 0.314449305650408 no 1019 0.32753361648127 1621 906558 YHR107C CDC12
SGTC_1032 k061-1018 98.7 µM 0.445870601498639 0.314770708246207 no 1020 0.327845359634944 1722 4005393
SGTC_2516 gossypol 71.55 µM 0.444901118863306 0.315131827975835 no 1021 0.328195607019123 1678 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_554 4483-2211 187 µM 0.443902721787548 0.31550390270387 no 1022 0.328556458321517 1573 747107
SGTC_386 1509-0011 3.07 µM 0.44360524604255 0.315614799814392 no 1023 0.328664006116899 1559 3107280
SGTC_710 3448-4187 58 µM 0.442613351619004 0.315984691847439 no 1024 0.329022712859698 1575 3946412
SGTC_824 1304-0008 100 µM 0.44235398631427 0.3160814433998 no 1025 0.329116535207473 1581 768245
SGTC_1265 0819-1001 68.8 µM 0.440592739449456 0.316738777727905 no 1026 0.329753930031044 1533 3106768
SGTC_1418 3966-3099 2.4 µM 0.438862003559204 0.317385288914815 no 1027 0.330380764971196 1626 740335
SGTC_3048 9093155 49.47 µM 0.437413422044783 0.317926830914157 no 1028 0.330905775941999 1571 25236002
SGTC_1921 5740136 50 µM 0.437275727026478 0.317978327521933 no 1029 0.330955698229928 1706 1774243
SGTC_1296 1068-0102 11.9 µM 0.43542259555137 0.318671722919893 no 1030 0.331627856095546 1626 767053
SGTC_2979 9012552 45.46 µM 0.435045592470714 0.3188128658931 no 1031 0.331764667102565 1610 17100905
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.43417463088651 0.319139038260719 no 1032 0.332080816961105 1619 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2859 9028643 45.46 µM 0.434089809718148 0.319170811009311 no 1033 0.332111612542324 1620 17151580
SGTC_1218 1348-1416 30.7 µM 0.432123422148124 0.319907762496106 no 1034 0.332825856144115 1579 6787668
SGTC_2031 5180455 200 µM 0.431089826206871 0.32029541308985 no 1035 0.333201528923829 1547 29949
SGTC_3261 9137475 49.47 µM 0.429088581966899 0.321046538001564 no 1036 0.333929380650389 1578 17027690
SGTC_2519 cryptotanshinone 88.04 µM 0.429055778085266 0.321058856361117 no 1037 0.333941316624206 1649 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_178 4092-0806 87.505 µM 0.42877339312127 0.321164904379382 no 1038 0.334044071762903 1560 2169044
SGTC_1561 5-methoxyflavone 52.9 µM 0.428653083294294 0.321210090461136 no 1039 0.334087854265474 1600 94525
SGTC_1828 st055811 49 µM 0.425105372081843 0.32254373075362 no 1040 0.335379930963104 1683 5877589
SGTC_109 0132-0036 33.701 µM 0.424852585779494 0.322638844552605 no 1041 0.335472070338019 1561 67274 A color developer.
SGTC_2939 9044578 71.43 µM 0.424739217419617 0.322681504492498 no 1042 0.335513395767082 1537 2653634
SGTC_1174 0739-0097 51.1 µM 0.423545027663436 0.32313101374367 no 1043 0.335948826770976 1601 728447
SGTC_2017 5132927 60.65 µM 0.423275856965986 0.323232368960757 no 1044 0.336047003479617 1537 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1531 st059297 52.4 µM 0.422657688307291 0.323465187717035 no 1045 0.336272515246545 1608 7566702
SGTC_2757 clomiphene 4.22 µM 0.421082843622906 0.32405862834684 no 1046 0.336847294496811 1739 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3286 9117135 37.221 µM 0.420703278284758 0.324201724966105 no 1047 0.336985883498197 1530 3438150
SGTC_866 0495-0101 262 µM 0.420132062581823 0.324417122968438 no 1048 0.337194490654553 1525 635694
SGTC_2210 7115885 190.385 µM 0.419211945006912 0.324764210858858 no 1049 0.337530621532911 1602 2927039
SGTC_165 k038-0023 64.381 µM 0.415881647110869 0.326021740561367 no 1050 0.338748304907189 1552 46368543
SGTC_2866 9034245 58.44 µM 0.414824675165171 0.326421270989834 no 1051 0.33913512733626 1710 6462273
SGTC_3053 9095903 49.47 µM 0.410686722398818 0.327987310865071 no 1052 0.340651132064506 1674 17174018
SGTC_246 cycloheximide 667 µM 0.409625734616962 0.328389338817661 no 1053 0.341040257981281 1582 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1772 st048439 82.2 µM 0.408256435878573 0.328908485313489 no 1054 0.341542709429154 1602 2927068 YDL195W SEC31
SGTC_3030 9087619 49.47 µM 0.407902016705118 0.329042911200308 no 1055 0.34167280605543 1577 25236973
SGTC_2113 5491891 107.031 µM 0.407221525949076 0.329301073129325 no 1056 0.341922646474397 1558 789979
SGTC_326 k292-0812 17.5 µM 0.407129979976044 0.329335809698495 no 1057 0.341956262627656 1716 3579357
SGTC_213 1246-0773 967 nM 0.405647257330636 0.329898624856757 no 1058 0.342500900346538 1642 6251622
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.405010680983069 0.330140376217181 no 1059 0.342734829902214 1599 3256 An antibiotic and ribosome inhibitor.
SGTC_1934 st074720 32.6 µM 0.403798081908475 0.330601078804353 no 1060 0.343180603544269 1550 17250992
SGTC_2762 leflunomide 42.06 µM 0.403584077414155 0.330682412177868 no 1061 0.343259298199318 1646 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_175 3793-3120 23.7 µM 0.403010118822504 0.330900587198165 no 1062 0.343470390278891 1608 5322297
SGTC_1372 2752-0194 270 µM 0.40290864730752 0.330939164860617 no 1063 0.343507714835075 1568 823334
SGTC_3023 9089636 49.47 µM 0.402494991439071 0.331096448025272 no 1064 0.343659886837456 1694 17249241
SGTC_671 0560-0003 407 µM 0.401878257229268 0.331331002421671 no 1065 0.343886812518122 1675 3238678
SGTC_3218 9131285 49.47 µM 0.401763119966115 0.331374798393592 no 1066 0.343929183195117 1748 17156417
SGTC_920 mycophenolic acid 780.421 nM 0.400766685086718 0.331753919096629 no 1067 0.344295954482732 1588 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3266 9136860 49.47 µM 0.399883092665789 0.33209025004446 no 1068 0.344621312876619 1608 4871271 YPR165W RHO1
SGTC_2101 5377231 179.231 µM 0.399719457494234 0.332152551054816 no 1069 0.344681579613371 1713 2844213
SGTC_467 ro 31-8220 72.8 µM 0.397605125838875 0.332957959753712 no 1070 0.345460640761202 1712 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2327 6189656 200 µM 0.396864858838738 0.333240130859287 no 1071 0.345733559628086 1750 5349088
SGTC_811 0416-0114 265 µM 0.396142324021165 0.333515633958015 no 1072 0.346000018394422 1629 6612453
SGTC_697 0508-1955 564 µM 0.395360977500493 0.333813663086085 no 1073 0.346288251774847 1744 6243113
SGTC_2970 9090938 41.86 µM 0.395192853446335 0.333877804387273 no 1074 0.346350283234516 1772 17217104
SGTC_2625 euphol 100 µM 0.394655971391645 0.334082663688142 no 1075 0.346548400131211 1774 6708538 A triterpene alcohol.
SGTC_141 0443-0274 32.331 µM 0.394578159163271 0.334112358780002 no 1076 0.34657711740306 1726 1627241
SGTC_684 1140-0066 328 µM 0.394007177408933 0.334330291451995 no 1077 0.346787870092159 1622 6813534
SGTC_102 gallobenzophenone 83.616 µM 0.393018577912027 0.334707752758071 no 1078 0.347152880012385 1740 70837
SGTC_3240 9133527 49.47 µM 0.391929657417526 0.335123711431282 no 1079 0.347555094529495 1620 17617455
SGTC_792 4534-1957 155 µM 0.391666158234069 0.335224396367866 no 1080 0.347652449027304 1672 1717904
SGTC_261 5-fluorouridine 15.376 µM 0.38857847413848 0.336405103227051 no 1081 0.348793996467328 1718 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_764 1951-2361 146 µM 0.388212929008838 0.336544992045393 no 1082 0.348929233034846 1573 5438930
SGTC_1605 st000082 49.1 µM 0.387217846949466 0.336925910092291 no 1083 0.349297469399113 1699 1114022
SGTC_2721 ifenprodil 61.44 µM 0.387203729727436 0.336931315378428 no 1084 0.349302694587448 1731 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_66 0109-0187 42.4 µM 0.387158226268208 0.336948738243393 no 1085 0.349319536915791 1564 759417
SGTC_2073 5212005 126 µM 0.386673436538223 0.337134381578986 no 1086 0.349498991969369 1707 691789
SGTC_1520 flindersine 88 µM 0.385962235787836 0.337406797571115 no 1087 0.34976231866576 1808 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3041 9091929 49.47 µM 0.38381524858697 0.338229689099939 no 1088 0.350557692684392 1691 25236887
SGTC_3111 9122088 49.47 µM 0.383681183416811 0.338281098933646 no 1089 0.350607380321196 1739 16876704
SGTC_2761 levamisole 97.89 µM 0.383341329407376 0.338411435910471 no 1090 0.350733349487128 1769 26879 An alkaline phosphatase inhibitor.
SGTC_1079 idarubicin 2.36 µM 0.382727047643537 0.338647067440807 no 1091 0.350961078772863 1688 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3051 9093778 49.47 µM 0.382608506120192 0.338692545901487 no 1092 0.351005031182954 1673 17217378
SGTC_2864 9034755 47.6 µM 0.381653961922236 0.339058842498419 no 1093 0.351359026343153 1654 4930451
SGTC_593 1203-0218 61.7 µM 0.381313150889445 0.339189662143376 no 1094 0.351485448249752 1755 3666956
SGTC_1035 k081-0041 55.2 µM 0.380854441361212 0.339365767501192 no 1095 0.351655629866927 1770 731709
SGTC_867 0518-0118 155 µM 0.37794979616055 0.340481716858759 no 1096 0.352733944643958 1679 6848158
SGTC_2462 5162487 171.77 µM 0.377832415245138 0.340526843442302 no 1097 0.352777545856311 1749 2259986
SGTC_551 k048-0028 34.9 µM 0.37682204005792 0.34091537214575 no 1098 0.353152930240427 1746 6836383
SGTC_1714 st033236 13.627 µM 0.376523029542618 0.341030385747174 no 1099 0.353264048952212 1754 2916566
SGTC_1880 MG-132 525 µM 0.3757920422732 0.341311620249568 no 1100 0.353535752139174 1747 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1669 st015249 58.4 µM 0.375435100624009 0.341448979317712 no 1101 0.353668452147686 1785 722793
SGTC_970 1315-0089 19.5 µM 0.375321616582518 0.341492654896802 no 1102 0.353710645776502 1576 6811083 YLR033W RSC58
SGTC_2949 9072542 2.23 µM 0.375308802803185 0.341497586553815 no 1103 0.35371541008219 1613 16457352
SGTC_818 4072-2707 53.5 µM 0.375166718025368 0.341552272732736 no 1104 0.353768240318489 1589 882871
SGTC_3179 9107801 49.47 µM 0.374975984818557 0.341625688150365 no 1105 0.353839163535037 1640 4818259
SGTC_3084 9116877 49.47 µM 0.37426987604569 0.341897529715309 no 1106 0.354101770786023 1758 27241325
SGTC_1119 parthenolide 318.541 nM 0.373404188497152 0.342230918647947 no 1107 0.354423821304072 1747 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2492 derrusnin 100 µM 0.370757779960768 0.343250851108494 no 1108 0.355408975148738 1630 1715307 Part of coumarin class of compounds.
SGTC_2727 riluzole 51.77 µM 0.370712959783799 0.343268134778316 no 1109 0.355425668283224 1687 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1754 st042065 16.137 µM 0.370432169113135 0.343376421444653 no 1110 0.355530254199473 1660 1126236 YIL048W NEO1
SGTC_576 1073-0113 22.7 µM 0.369167748345792 0.343864203371437 no 1111 0.356001346861542 1736 5439563
SGTC_1301 naphtanilide LB 4.81 µM 0.368171314506726 0.344248785874601 no 1112 0.356372749058219 1781 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_283 0987-0079 11.7 µM 0.367339101655687 0.344570109327617 no 1113 0.356683045385073 1771 411556
SGTC_3244 9134489 49.47 µM 0.366327521153427 0.344960838987142 no 1114 0.357060347914575 1629 16584271
SGTC_2001 4023502 57.655 µM 0.365438719657731 0.345304280956579 no 1115 0.357391971361937 1718 108941 YCR052W RSC6
SGTC_2061 5245884 80.95 µM 0.364064295668542 0.345835623214239 no 1116 0.357904998924932 1665 573863
SGTC_665 3914-0008 307 µM 0.363864267059053 0.345912978157044 no 1117 0.357979684492637 1627 1069549
SGTC_24 0417-1663 219 µM 0.363485884293322 0.346059323699585 no 1118 0.35812097780685 1675 4329390
SGTC_1308 1187-1617 41.4 µM 0.363335731236161 0.34611740415282 no 1119 0.358177052404957 1662 2882570
SGTC_3263 9137018 49.47 µM 0.363202163388005 0.346169072351359 no 1120 0.35822693583462 1583 43844957
SGTC_342 k048-0088 23.3 µM 0.362613633993695 0.346396767923283 no 1121 0.358446762039449 1628 6820570
SGTC_3205 9113483 49.47 µM 0.361247284457088 0.346925607541693 no 1122 0.358957298706737 1789 17018033
SGTC_791 1348-1292 225 µM 0.360927884153368 0.347049273090183 no 1123 0.359076679046407 1781 5437054
SGTC_1151 3909-8316 15.3 µM 0.360829836283677 0.347087238575662 no 1124 0.359113328573181 1677 800431
SGTC_73 0327-0325 16.231 µM 0.360364274331854 0.347267531516169 no 1125 0.35928736967963 1846 53298
SGTC_13 0199-0087 65 µM 0.359489147371007 0.347606525624899 no 1126 0.359614597554868 1732 4589825
SGTC_372 0155-0182 15.9 µM 0.35722391850522 0.3484845629972 no 1127 0.360462090619088 1752 771486
SGTC_2569 tetrandrine 100 µM 0.354867156224496 0.349398942544453 no 1128 0.361344557353605 1621 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2083 5306046 65.942 µM 0.350528543137293 0.351084527149058 no 1129 0.362971036466893 1677 539837
SGTC_1202 1988-0068 29.6 µM 0.349069493970827 0.351652039952526 no 1130 0.363518569042615 1620 2850480
SGTC_271 rotenone 740 µM 0.348748480403015 0.351776946055106 no 1131 0.363639072218914 1769 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2486 5283202 22.39 µM 0.347784729700761 0.352152036703012 no 1132 0.364000929279011 1643 1377751
SGTC_300 r073-0011 5.04 µM 0.346872449252254 0.352507227763718 no 1133 0.364343572698778 1741 2735780
SGTC_1817 st052116 64.4 µM 0.346379790177592 0.35269909521142 no 1134 0.364528655634748 1763 4361398
SGTC_1732 st034308 51.822 µM 0.346370701218796 0.352702635283924 no 1135 0.364532070485947 1663 830119
SGTC_3194 9111903 49.47 µM 0.345237320518774 0.353144177345743 no 1136 0.364957981921931 1753 17087251
SGTC_659 k018-0002 107 µM 0.344846375615857 0.353296527435065 no 1137 0.365104933210198 1833 6797879 YHR007C ERG11
SGTC_898 1000-0849 28.3 µM 0.344570852482301 0.35340391212327 no 1138 0.365208510805422 1782 6751807
SGTC_1500 4488-1866 171 µM 0.343556971053324 0.353799171175954 no 1139 0.365589744548044 1804 2900003
SGTC_950 1165-0508 94.1 µM 0.342498019916015 0.354212168853659 no 1140 0.365988066936393 1661 6148369
SGTC_413 propylparaben 100 µM 0.341759864296243 0.354500155730424 no 1141 0.366265808209899 1665 7175 A pharmaceutical preservative.
SGTC_2418 pentamidine 31.67 µM 0.341297212313306 0.354680698984231 no 1142 0.366439923158006 1647 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1708 st033234 31.827 µM 0.340713019804215 0.354908718309603 no 1143 0.366659818073854 1793 674664
SGTC_1483 3453-0561 55.9 µM 0.339429523284134 0.355409869212113 no 1144 0.367143090469229 1766 4546991
SGTC_2429 5902844 64.44 µM 0.336962208557889 0.356373952794184 no 1145 0.368072694482384 1850 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2023 5144124 124 µM 0.336785395815542 0.356443076311742 no 1146 0.36813934152715 1697 2830192
SGTC_2004 4023728 41.89 µM 0.335816966033871 0.356821759739411 no 1147 0.368504447689872 1850 360084 YDR527W RBA50
SGTC_1643 st009866 20.2 µM 0.334748554790727 0.357239702490252 no 1148 0.368907385472461 1809 3156273 YOR207C RET1
SGTC_1411 3909-8223 150 µM 0.334682173791994 0.357265675169472 no 1149 0.368932424986307 1823 X1411
SGTC_1244 0416-0015 52.5 µM 0.33413250742666 0.357480766754471 no 1150 0.369139785482604 1727 96201
SGTC_2237 6667747 47.222 µM 0.3328317568948 0.35798994757938 no 1151 0.369630642533627 1688 729940 YDL015C TSC13
SGTC_2576 guaiol 23.12 µM 0.332595314871703 0.358082530350179 no 1152 0.369719890206731 1889 227829
SGTC_128 0906-2981 13.371 µM 0.331852322379819 0.35837351560558 no 1153 0.370000386652277 1814 6740226
SGTC_3320 9137005 35.139 µM 0.331253247867797 0.358608196799725 no 1154 0.370226601185992 1727 4908713
SGTC_52 0329-0193 875 nM 0.330898074102043 0.358747357640023 no 1155 0.370360738373845 1815 3739292
SGTC_2764 methyldopa 94.69 µM 0.33048591448112 0.358908869648882 no 1156 0.370516416964675 1847 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1214 0358-0031 63.7 µM 0.330008510498247 0.359095980343352 no 1157 0.370696765791866 1894 4301366
SGTC_314 1671-0008 2.74 µM 0.32932507749061 0.35936389957858 no 1158 0.370954995618572 1742 3913060
SGTC_439 amiodarone 34.4 µM 0.327952765776659 0.359902081616972 no 1159 0.371473688317545 1800 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1284 0929-0043 16 µM 0.327761935073168 0.359976942079235 no 1160 0.371545835115956 1721 1239883
SGTC_416 estradiol valerate 100 µM 0.326728812671732 0.36038231606284 no 1161 0.371936502927895 1770 13791 A steroid.
SGTC_598 3937-0236 20.2 µM 0.326543776767686 0.36045493657826 no 1162 0.372006486862718 1796 1379313
SGTC_3247 9135149 49.47 µM 0.325203240059217 0.360981203405908 no 1163 0.37251362831821 1748 8934436 YOR116C RPO31
SGTC_475 α-linolenic acid 10 µM 0.325088836399948 0.36102612811018 no 1164 0.372556918876516 1810 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_706 4262-0057 46.9 µM 0.324421877588523 0.361288071583609 no 1165 0.372809329374208 1696 883298
SGTC_1064 honokiol 6.76 µM 0.32358352525862 0.361617420934991 no 1166 0.373126681199959 1749 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1171 0368-0077 21.4 µM 0.323050280412269 0.361826961225239 no 1167 0.373328581747864 1729 3239779
SGTC_3242 9133940 49.47 µM 0.322906396447739 0.361883507995882 no 1168 0.373383065968784 1796 17248444
SGTC_209 4077-0173 175.592 µM 0.322150551203372 0.362180606635236 no 1169 0.373669321760937 1766 15993494
SGTC_2883 9059145 45.46 µM 0.321932959638327 0.362266150336823 no 1170 0.373751741566727 1705 16476510
SGTC_1923 st058458 19.1 µM 0.321207904050093 0.362551247498374 no 1171 0.37402642135177 1860 3534982
SGTC_124 0136-0217 7.121 µM 0.320228319285829 0.362936548441833 no 1172 0.374397628459716 1908 3976905
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.320191398939005 0.362951073070995 no 1173 0.374411621458159 1777 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_944 3370-0224 231 µM 0.31824074677641 0.36371874823131 no 1174 0.375151163336987 1695 4580514
SGTC_1355 1499-0035 1.68 µM 0.31711088642869 0.364163653039238 no 1175 0.375579732346764 1721 1548538
SGTC_1484 3473-2379 286 µM 0.315611472786313 0.36475435943735 no 1176 0.376148714227801 1791 671917
SGTC_2253 7938677 135.83 µM 0.315602221776727 0.364758004947467 no 1177 0.376152225541763 1876 2301972
SGTC_2603 homopterocarpin 100 µM 0.315578694059692 0.364767276480416 no 1178 0.376161155770176 1737 101795 A weak amylase inhibitor.
SGTC_3183 9108214 49.47 µM 0.315293763235515 0.364879565029502 no 1179 0.376269309959209 1830 4974831
SGTC_2405 ticlatone 3.52 µM 0.314650907961907 0.365132950787634 no 1180 0.376513360974907 1529 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1315 1237-0019 3.69 µM 0.31379671290038 0.365469728661361 no 1181 0.376837720554791 1836 825140
SGTC_3085 9117376 49.47 µM 0.313639128160929 0.365531869903782 no 1182 0.376897568993258 1802 16480349
SGTC_1370 2001-0092 44.6 µM 0.313222274757263 0.3656962669738 no 1183 0.377055898234142 1892 790957
SGTC_2215 7188065 200 µM 0.312737436624357 0.365887506635956 no 1184 0.377240075436705 1852 940217
SGTC_3031 9088762 49.47 µM 0.311965371203361 0.366192109072418 no 1185 0.377533420331844 1738 205253
SGTC_331 k048-0133 24.5 µM 0.310846732615707 0.366633594362066 no 1186 0.377958570410698 1742 6813582
SGTC_2952 9073731 13.78 µM 0.308551204088289 0.367540106782324 no 1187 0.378831472097321 1717 16457353
SGTC_2257 7960413 200 µM 0.308481804718629 0.367567524368413 no 1188 0.378857871675571 1831 2974689 YIL048W NEO1
SGTC_1875 nocodazole 6 µM 0.30810245155526 0.367717407223815 no 1189 0.379002187921509 1901 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_740 k014-0057 261 µM 0.308085341971343 0.367724167714406 no 1190 0.3790086972696 1877 4012779
SGTC_2961 9083290 32.55 µM 0.307770255199885 0.367848674919965 no 1191 0.379128578291206 1781 17741490
SGTC_912 3474-0017 2.18 µM 0.307646324622422 0.367897650156263 no 1192 0.379175733327611 1854 3360550
SGTC_1356 1502-0781 85.8 µM 0.306565208834323 0.368324979559193 no 1193 0.379587169282835 1772 567702
SGTC_2353 9059630 146.67 µM 0.305701108092357 0.368666647267091 no 1194 0.379916114770072 1842 4779114
SGTC_1519 esterone 74 µM 0.305474633286638 0.368756213187397 no 1195 0.380002343481137 1671 698 A steroid.
SGTC_1044 1222-0021 1.78 µM 0.303852367977843 0.369397992429942 no 1196 0.380620183919168 1824 4306703
SGTC_3018 9082602 49.47 µM 0.303301861988481 0.369615859196843 no 1197 0.380829913661144 1791 17332089
SGTC_294 k038-0071 157 µM 0.302660381160883 0.369869782735414 no 1198 0.38107434683842 1776 24152826
SGTC_181 1447-1644 8.07 µM 0.302489491067202 0.369937437384998 no 1199 0.381139471694656 1895 534600
SGTC_3172 9105863 49.47 µM 0.301338464021684 0.370393228788535 no 1200 0.381578206568037 1821 2348785
SGTC_164 4100-3994 89.624 µM 0.30133732629431 0.370393679403595 no 1201 0.381578640308881 1920 4615967
SGTC_1026 k007-1105 30.6 µM 0.299531153427927 0.371109266822384 no 1202 0.382267402750329 1765 7066794
SGTC_1168 k815-0004 80.5 µM 0.299428753710618 0.371149849933539 no 1203 0.382306462842964 1770 642433
SGTC_1986 st071812 45 µM 0.299257965455505 0.371217540014584 no 1204 0.382371612221024 1783 11838594
SGTC_2423 st077119 87.2 µM 0.299229846969265 0.371228684855045 no 1205 0.38238233869879 1782 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1016 4226-1401 38 µM 0.29853899647193 0.371502539274168 no 1206 0.382645908687181 1764 2901613
SGTC_2160 5660466 132.927 µM 0.296652994770452 0.37225048469438 no 1207 0.383365723524656 1910 2859134
SGTC_828 2074-0507 139 µM 0.296445656850865 0.372332739670581 no 1208 0.383444881111669 1884 X828
SGTC_1662 st014054 52 µM 0.296410650816462 0.372346627818557 no 1209 0.383458246215249 1835 2838777
SGTC_1224 0823-0416 294 µM 0.295722649445449 0.372619616285129 no 1210 0.383720949328823 1854 3598164
SGTC_2766 oltipraz 83.91 µM 0.293862060398338 0.373358189896549 no 1211 0.38443165506957 1881 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_176 1486-1328 72.834 µM 0.291986651350606 0.374103117530274 no 1212 0.385148415077138 1736 22310231
SGTC_131 0141-0277 33.849 µM 0.290072033905637 0.374864104307173 no 1213 0.385880565070456 1891 1547771
SGTC_917 harmaline 728.087 nM 0.289656410580482 0.375029363088569 no 1214 0.386039553305847 1843 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2401 5128683 200 µM 0.289473288692016 0.375102182696243 no 1215 0.386109608929685 1705 708373
SGTC_2896 9052656 71.43 µM 0.289066918243056 0.375263794441447 no 1216 0.386265084411125 1828 6469436
SGTC_2984 9022109 38.96 µM 0.288418044007656 0.375521894265878 no 1217 0.386513378591984 1845 6459207
SGTC_899 1083-0020 478 µM 0.286613240363428 0.376240075708465 no 1218 0.387204237626308 1911 767123
SGTC_3206 9114350 49.47 µM 0.285393548248194 0.376725667982638 no 1219 0.387671324927391 1844 17087243
SGTC_1693 xanthone 101.9 µM 0.284623588298706 0.377032310278842 no 1220 0.38796626877819 1864 7020 An insecticide.
SGTC_1534 6-azauridine 81.6 µM 0.283283893111535 0.377566038691908 no 1221 0.388479611619921 1807 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_234 nsc-17383 10.7 µM 0.282794512594383 0.377761064020248 no 1222 0.388667180512122 1906 408974
SGTC_1489 4065-0444 182 µM 0.282736016717421 0.377784377573032 no 1223 0.388689602445348 1944 2877968
SGTC_781 4335-2806 94.4 µM 0.282451669980627 0.377897710407438 no 1224 0.388798600084323 1931 845254
SGTC_1740 st038286 13.222 µM 0.282363073072043 0.377933024860711 no 1225 0.388832563416251 1837 716786
SGTC_255 tunicamycin 200.472 nM 0.279749280126467 0.378975332429823 no 1226 0.389834933540243 1940 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_307 1501-1223 22.3 µM 0.279646503014066 0.379016335113392 no 1227 0.38987436282063 1826 2830329
SGTC_1435 4092-0789 56.7 µM 0.278363887005205 0.379528146074142 no 1228 0.390366519186284 1907 2248285
SGTC_443 clozapine 122 µM 0.277379409028332 0.379921132294664 no 1229 0.390744395387178 1950 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_493 zm226600 134 µM 0.277131881932465 0.380019960268342 no 1230 0.390839420972283 1857 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1997 st073024 93.8 µM 0.276696231217161 0.380193917737058 no 1231 0.391006682993595 1931 686268
SGTC_1930 st074634 34.3 µM 0.276667025387419 0.380205580635487 no 1232 0.39101789688645 1730 684253 YOR116C RPO31
SGTC_2771 fluoxetine 41.05 µM 0.275820943697964 0.380543497574415 no 1233 0.391342798362037 1897 3386 A selective serotonin reuptake inhibitor.
SGTC_113 0099-0221 2.5 µM 0.275726271579775 0.38058131438935 no 1234 0.391379157859914 1918 89219
SGTC_724 3910-0327 137 µM 0.274851915036144 0.380930630349445 no 1235 0.39171500550908 1775 2885483
SGTC_1360 1598-0022 39.8 µM 0.274658530599779 0.38100790287694 no 1236 0.391789296995038 1893 761525
SGTC_1545 lovastatin 49.4 µM 0.274180324907012 0.381199004614952 no 1237 0.391973023709555 1848 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2391 6285546 200 µM 0.272603563706212 0.38182931884919 no 1238 0.392578986112371 1774 846083
SGTC_2162 5663267 200 µM 0.271723594511465 0.382181225112488 no 1239 0.392917278925307 1911 6456493
SGTC_2352 9027995 87.8 µM 0.270351875323025 0.382729979932574 no 1240 0.39344477993606 1867 2997347
SGTC_2589 lobaric acid 100 µM 0.269934743697357 0.382896899749624 no 1241 0.393605228686121 1763 73157 A novel microtubule depolymerizer.
SGTC_2711 st079103 59.1 µM 0.269716541076794 0.382984224599631 no 1242 0.393689167036854 1931 54693780
SGTC_465 cgp-37157 41 µM 0.269502333467286 0.383069956428563 no 1243 0.393771573389018 1926 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_451 chloral hydrate 100 µM 0.269176428580395 0.383200403592606 no 1244 0.393896959164976 1865 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_657 3534-0529 86.7 µM 0.269062654698827 0.383245946011646 no 1245 0.393940734117171 1924 1049549
SGTC_469 w7 172 µM 0.26740506267417 0.383909644361169 no 1246 0.394578650937859 1882 45115570 A P450 inhibitor.
SGTC_473 2-arachidonoylglycerol 10 µM 0.267138504550162 0.384016405837977 no 1247 0.39468126107004 1778 5282280 An endocannabinoid.
SGTC_359 0081-0058 15.9 µM 0.266772039861775 0.384163196115963 no 1248 0.39482234162957 1948 3494159
SGTC_3130 9127414 49.47 µM 0.266064190465378 0.384446777720748 no 1249 0.395094886563447 1882 1494646
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.264787197779589 0.384958528258891 no 1250 0.395586699843538 1727 641818 YHR062C RPP1
SGTC_1800 st050079 29.0735 µM 0.264628847814531 0.38502200046444 no 1251 0.395647697402691 1853 3645560
SGTC_2155 5570423 76 µM 0.264386226096168 0.385119257712993 no 1252 0.395741162012676 1840 797402
SGTC_2371 9071574 200 µM 0.264248713306087 0.38517438424632 no 1253 0.39579413841288 1939 45596039
SGTC_16 erodoxin 22.806 µM 0.263418529549574 0.38550724001845 no 1254 0.396114005136341 1887 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2145 5634607 200 µM 0.261742016907247 0.386179681747266 no 1255 0.396760172317456 1792 308662
SGTC_1001 4048-4355 44.4 µM 0.261107852800293 0.386434131410567 no 1256 0.397004668016422 1821 21824233
SGTC_2951 9072950 58.06 µM 0.260471947499914 0.386689328747932 no 1257 0.397249875670337 1949 16488155
SGTC_2030 5175110 200 µM 0.260305850573418 0.386755993751509 no 1258 0.397313930010545 1889 2831986
SGTC_2759 disulfiram 3.38 µM 0.258812649375355 0.387355457883583 no 1259 0.397889898773022 1812 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1909 st060837 51.5 µM 0.256050095483722 0.388465226846164 no 1260 0.398956077836958 1803 678937
SGTC_1162 k048-0130 20.1 µM 0.254442119341851 0.389111600685127 no 1261 0.399577007425112 1833 6797406
SGTC_3191 9110352 49.47 µM 0.253465771871222 0.389504222508832 no 1262 0.399954153909388 1870 17122424
SGTC_2581 avocatin a 64 µM 0.25157688833303 0.390264125384485 no 1263 0.400684062296757 1852 6710728 A skin care supplement.
SGTC_2787 5284540 71.43 µM 0.249278239199237 0.39118944366073 no 1264 0.401572781362766 1846 736958
SGTC_3011 9081274 71.4286 µM 0.249023284485227 0.391292113415035 no 1265 0.401671385118399 1832 6625322
SGTC_2125 5246583 200 µM 0.248718846585164 0.39141471987186 no 1266 0.40178913470066 2024 835267
SGTC_977 1348-1378 135 µM 0.24758901563238 0.391869831592635 no 1267 0.402226205210281 1891 X977
SGTC_1183 1254-0324 198 µM 0.246973893256449 0.392117673758755 no 1268 0.402464214243203 1937 5799357
SGTC_40 0327-0103 19.753 µM 0.246749069566684 0.3922082695736 no 1269 0.402551214203587 1805 409036
SGTC_2549 cedrol 20.94 µM 0.245739429040159 0.392615190160465 no 1270 0.402941973962529 1962 6708665 A sedative which affects the nervous system.
SGTC_2053 5265679 138 µM 0.245058924004783 0.39288952385435 no 1271 0.403205403597492 1850 764595
SGTC_2686 alizarin 95.37 µM 0.244547475993871 0.393095740200453 no 1272 0.403403418658395 1818 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2158 5657123 3.6195 µM 0.24448042759085 0.393122776408769 no 1273 0.403429379328955 1977 2858827
SGTC_3213 9129884 49.47 µM 0.243407087820508 0.393555653794891 no 1274 0.403845026806082 1779 17190742
SGTC_317 4495-0002 170 µM 0.24329641065175 0.393600297334249 no 1275 0.403887892378822 1844 15991618
SGTC_477 mead ethanolamide 10 µM 0.242507040210635 0.393918744006062 no 1276 0.404193651172768 1946 16061185
SGTC_700 3453-2283 142 µM 0.241998882890596 0.394123781640212 no 1277 0.404390514416364 1939 565664
SGTC_2781 5567276 71.43 µM 0.24180587995574 0.394201664557135 no 1278 0.404465291276418 1931 2853274
SGTC_2148 5546263 113.568 µM 0.24160539111078 0.394282572760352 no 1279 0.404542972165331 1872 792097
SGTC_611 3453-1652 23.7 µM 0.241051951670537 0.394505939479917 no 1280 0.404757425899747 1984 1560575
SGTC_1497 4476-2978 41.3 µM 0.240389352198163 0.394773408528432 no 1281 0.405014215975949 1934 1528379
SGTC_1612 st002233 45.4 µM 0.237822858829621 0.395809882403376 no 1282 0.406009244238501 1974 1035021
SGTC_2869 9037858 32.47 µM 0.237493592242957 0.39594290964805 no 1283 0.406136944838677 1978 27187042
SGTC_580 1123-0028 41 µM 0.235839053817055 0.396611544145783 no 1284 0.406778781106789 1958 1677248 YPR107C YTH1
SGTC_3091 9116372 49.47 µM 0.235188059044152 0.396874708593358 no 1285 0.407031386799298 1922 17169793
SGTC_2032 5185112 25.99 µM 0.234787665498316 0.397036590904822 no 1286 0.407186770840982 1956 5718189
SGTC_2945 9067681 61.76 µM 0.234508475894736 0.397149479994158 no 1287 0.407295126909937 1937 16456930
SGTC_652 0437-0092 114 µM 0.233919139059772 0.397387804037123 no 1288 0.407523877273958 1854 3091274
SGTC_1005 4092-0690 4.4 µM 0.232405707175741 0.398000001527373 no 1289 0.408111458292625 1852 1529343
SGTC_3327 9140648 26.9345 µM 0.23205645507929 0.398141313028624 no 1290 0.408247082763826 1993 8029710
SGTC_2726 cimetidine 79.27 µM 0.231058749580243 0.398545069937578 no 1291 0.408634580539109 1995 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2729 fluphenazine 10.66 µM 0.231052048590567 0.398547782098364 no 1292 0.408637183431791 1904 3372 An atypical antipsychotic.
SGTC_956 1185-0240 191 µM 0.231048695789134 0.398549139114169 no 1293 0.408638485775604 1899 1416193
SGTC_3070 9117005 49.47 µM 0.229685606098972 0.399100938683517 no 1294 0.409168040290093 1978 8779016
SGTC_1623 st003709 20.3 µM 0.22896164499606 0.399394091294972 no 1295 0.409449363564039 1833 16192618
SGTC_3094 9117742 49.47 µM 0.228721357132692 0.399491403290233 no 1296 0.409542747083968 1996 17149698
SGTC_1745 st081495 74 µM 0.228502322335003 0.399580113640456 no 1297 0.409627875457074 1903 13842402 YBL026W LSM2
SGTC_3271 9137798 49.47 µM 0.227959482566205 0.399799989198948 no 1298 0.409838869726512 2007 6498326
SGTC_351 caspofungin 25 nM 0.227812591136448 0.399859492580777 no 1299 0.409895968873855 1925 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2671 danthron 100 µM 0.22657824486779 0.400359598365927 no 1300 0.410375855221152 1905 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1574 spiramycin 23.7 µM 0.225376364699197 0.400846707274134 no 1301 0.410843248459425 1912 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2138 5575593 77.673 µM 0.225118606357383 0.40095119402307 no 1302 0.410943503338657 1874 762213
SGTC_3176 9106582 49.47 µM 0.224332840766869 0.401269761228358 no 1303 0.411249162042938 2022 17018027
SGTC_957 1187-1561 14.1 µM 0.222896627143546 0.401852204333695 no 1304 0.41180798075436 2010 1538454
SGTC_2349 9023730 187.07 µM 0.221901691102283 0.402255819346477 no 1305 0.412195207020635 2004 4126287
SGTC_516 3992-2719 87.3 µM 0.221820520245678 0.402288752476157 no 1306 0.412226802263448 1785 5350887 YDR037W KRS1
SGTC_1570 verbenone 133 µM 0.221565239908009 0.402392330874735 no 1307 0.412326172228185 2043 29025 A natural terpanoid with antifungal properties.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.220899610942911 0.402662437873701 no 1308 0.41258530017997 1873 6312947
SGTC_1789 tunicamycin 25 nM 0.220607414382627 0.402781023624279 no 1309 0.412699063725713 2026 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2876 9059903 25.97 µM 0.217896057361511 0.403881832438194 no 1310 0.413755049557924 2019 6916095
SGTC_2255 7941087 197.44 µM 0.217602169245282 0.404001196691931 no 1311 0.413869547089338 2041 935561
SGTC_2598 perillyl alcohol 100 µM 0.217344586511393 0.404105822669011 no 1312 0.413969906223513 1972 10819 An apoptosis inducer.
SGTC_1485 3909-9022 254 µM 0.215982295628965 0.40465927729509 no 1313 0.414500773958586 2017 714516
SGTC_2222 6885208 172.143 µM 0.215750490549313 0.404753471211036 no 1314 0.414591121080297 1963 609514
SGTC_1752 st044819 83.042 µM 0.215748961485365 0.404754092563986 no 1315 0.41459171705518 1883 441209 YML126C ERG13
SGTC_446 go6976 132 µM 0.215438590249877 0.404880220501461 no 1316 0.414712692820595 2045 3501 A protein kinase C inhibitor.
SGTC_2740 felodipine 17.08 µM 0.215227825237825 0.404965876329494 no 1317 0.414794848920564 2052 3333 L-type calcium channel blocker
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.214935562372082 0.405084660777653 no 1318 0.414908779010983 1904 15053
SGTC_3102 9121669 49.47 µM 0.213054668611782 0.405849321540402 no 1319 0.415642161015801 1929 41905072
SGTC_701 4424-0219 185 µM 0.212626632371451 0.406023386197189 no 1320 0.415809098392777 2058 2911779
SGTC_2640 pentamidine 10.38 µM 0.212327910522888 0.40614487504228 no 1321 0.415925611180852 2059 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1482 3346-2049 8.48 µM 0.212127872744593 0.406226234568657 no 1322 0.416003637591419 2009 3826804
SGTC_778 3456-2434 196 µM 0.210992049427835 0.406688274215094 no 1323 0.41644673767332 2058 5539063
SGTC_309 k408-0051 1.48 µM 0.209119147431663 0.4074504323266 no 1324 0.417177613828052 1953 3640463
SGTC_4 0960-0234 25.671 µM 0.207377236949611 0.408159599446646 no 1325 0.417857629237685 1920 6821112
SGTC_2066 5222451 176 µM 0.207350511738583 0.408170482172456 no 1326 0.417868064273072 1988 2281147
SGTC_2420 aureobasidin a 50 nM 0.204460408747171 0.409347772202446 no 1327 0.418996863845643 2049 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2803 7707263 71.43 µM 0.203315095703059 0.409814544999003 no 1328 0.419444378635107 1900 2199229
SGTC_3272 9137413 49.47 µM 0.203068828351936 0.409914928080139 no 1329 0.419540617734784 2030 17614870
SGTC_1330 1469-0054 61.8 µM 0.202877268530176 0.409993015453731 no 1330 0.419615480944749 2069 7102664
SGTC_2467 5474540 200 µM 0.202732591935757 0.41005199373239 no 1331 0.419672023718778 2012 5413519
SGTC_627 1391-0720 175 µM 0.201895649414018 0.41039321824873 no 1332 0.419999151653958 1964 997839
SGTC_1049 3226-0134 66 µM 0.201588913862691 0.410518292453543 no 1333 0.420119056378944 2035 5702385
SGTC_756 0508-1999 28.3 µM 0.201270270439647 0.410648231838671 no 1334 0.420243623812458 1847 6753853
SGTC_2146 5545642 200 µM 0.200577533308004 0.41093075646227 no 1335 0.420514463435348 2037 825326
SGTC_373 0844-0104 25.9 µM 0.199955880338825 0.41118432959981 no 1336 0.420757543308173 2072 5375804
SGTC_2490 carminic acid 95.39 µM 0.199614947133607 0.411323412507687 no 1337 0.420890868465344 1967 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2033 5192550 145 µM 0.198805168339138 0.411653804527376 no 1338 0.421207576471806 1912 182073
SGTC_75 0159-0059 199.013 µM 0.198461588772549 0.411794004897952 no 1339 0.421341967352294 2043 5377270
SGTC_1287 0971-0001 34.6 µM 0.198301609401634 0.41185928959427 no 1340 0.421404546286768 1968 4665869
SGTC_3236 9132701 49.47 µM 0.197997688606403 0.411983320908811 no 1341 0.421523436078828 1924 24282524
SGTC_3273 9137859 49.47 µM 0.197915136480489 0.412017012286793 no 1342 0.421555730613767 2098 2377234
SGTC_655 k060-0012 42 µM 0.197437294592784 0.412212043034813 no 1343 0.421742673549442 1944 5994525
SGTC_2012 4023501 200 µM 0.196134945490607 0.412743705623332 no 1344 0.422252272438792 1917 3477460
SGTC_167 3672-0051 66.205 µM 0.19416912639004 0.41354652187124 no 1345 0.423021728180414 1977 3237971
SGTC_1406 3909-7906 11.9 µM 0.192118417750582 0.414384391237299 no 1346 0.423824724178271 2020 X1406
SGTC_116 0155-0182 31.788 µM 0.189867232012124 0.415304619302201 no 1347 0.424706585211606 1936 771486
SGTC_716 1683-5115 658 µM 0.189739656807097 0.415356782798145 no 1348 0.424756571804455 2091 723597
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.189529253077453 0.415442816834653 no 1349 0.424839014962206 2036 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_678 1218-2179 85.9 µM 0.187883833662142 0.416115767958523 no 1350 0.425483857959853 2058 6820081 YOR116C RPO31
SGTC_478 N-arachidonylglycine 10 µM 0.187485852939147 0.416278572948127 no 1351 0.425639857370549 2065 5283389
SGTC_263 alizarin 107.927 µM 0.187197223051256 0.4163966539518 no 1352 0.425753001019398 2010 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2029 5175081 200 µM 0.186795440108978 0.416561039416796 no 1353 0.425910511129056 2023 1380876
SGTC_1692 fluoroquinolonic acid 71 µM 0.186205794189783 0.416802313552515 no 1354 0.426141690159173 2035 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1944 st076371 56.9 µM 0.185428857479541 0.417120272072244 no 1355 0.426446337941201 1905 24208455
SGTC_2707 st078556 66.6 µM 0.184015271506862 0.417698915896528 no 1356 0.427000737284672 2106 17250899
SGTC_222 nsc-310342 10.666 µM 0.183009253128769 0.418110832756387 no 1357 0.427395379144569 2101 432556
SGTC_1961 st076550 68.7 µM 0.18287038223372 0.418167700874962 no 1358 0.427449861269584 1999 1579337
SGTC_1358 1509-0022 2.48 µM 0.182860219918595 0.418171862445839 no 1359 0.427453848225017 1997 3258434
SGTC_1347 1493-0251 600 nM 0.180649338483148 0.419077457785824 no 1360 0.428321413214236 2089 3986378
SGTC_3098 9119039 49.47 µM 0.179421849094208 0.419580433084874 no 1361 0.428803238328011 2114 17161528
SGTC_810 3825-7150 143 µM 0.179333659325686 0.419616574740076 no 1362 0.428837859459428 2128 22330411 YGL099W LSG1
SGTC_2785 7756463 72.73 µM 0.179011751361661 0.419748503808015 no 1363 0.428964237244105 1975 2201551
SGTC_2265 7929201 200 µM 0.178904815059201 0.419792332016762 no 1364 0.429006220958301 2063 1265108
SGTC_2459 5811157 9.22 µM 0.178560027536569 0.419933651132737 no 1365 0.42914159168977 2115 2870684 YBR192W RIM2
SGTC_1014 4130-3005 69.3 µM 0.178080674357132 0.420130142237418 no 1366 0.429329809533652 1927 743608
SGTC_1872 amphotericin b 148 nM 0.177571448451385 0.420338900244147 no 1367 0.429529774492023 2065 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1317 1273-0028 910 nM 0.176121998179575 0.420933227278481 no 1368 0.430099049503093 1995 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_660 4031-1742 102 µM 0.175364870520042 0.421243748753664 no 1369 0.430396471038676 1969 6738706
SGTC_1098 clofazimine 15.1 µM 0.174949554285916 0.42141410360993 no 1370 0.430559635992426 2069 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1321 1326-2144 215 µM 0.174792804222698 0.421478403343818 no 1371 0.430621221346513 2095 3513030
SGTC_2472 5377652 49.4 µM 0.174291923288041 0.421683881472087 no 1372 0.430818023190761 1951 1610903
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.174007133849833 0.421800721147272 no 1373 0.430929927880919 1931 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1133 3473-0247 50 µM 0.173232151362787 0.422118705623673 no 1374 0.431234476268889 1860 711311
SGTC_1895 st058434 18.3 µM 0.17263491857903 0.422363791948991 no 1375 0.431469201454887 2127 5393175
SGTC_252 miconazole 1.30953 nM 0.171780409997569 0.422714508759054 no 1376 0.431805083567348 2075 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2051 5263410 176 µM 0.170035277656662 0.42343095522091 no 1377 0.432491196521169 2135 227584
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.168007998713559 0.424263551939248 no 1378 0.433288493231992 2091 229346 A bile salt which induces apoptosis.
SGTC_59 0330-0160 1.33 µM 0.16689889985275 0.424719198479936 no 1379 0.43372479939935 2043 4293482
SGTC_425 3825-7017 13.1 µM 0.166859157436494 0.4247355275647 no 1380 0.433740435090552 2048 3397440
SGTC_19 0279-0214 38.434 µM 0.166260574753172 0.424981484618925 no 1381 0.43397594547885 2080 3566274 YBR002C RER2
SGTC_1682 st012968 530 nM 0.164580292045972 0.425672066942822 no 1382 0.434637172167318 1929 24207270
SGTC_3088 9117578 49.47 µM 0.163883997149126 0.425958305354053 no 1383 0.434911232595105 2121 678341
SGTC_2557 derrustone 83.84 µM 0.163266216923437 0.426212300003883 no 1384 0.435154415976784 1922 629853 An antioxidant.
SGTC_1727 st034309 9.9045 µM 0.162998997680659 0.426322174224406 no 1385 0.435259611926164 2132 870305
SGTC_349 k015-0014 24 µM 0.162692654317089 0.426448142392001 no 1386 0.435380215468625 1964 2196908
SGTC_906 1165-0455 526 µM 0.161744630744818 0.426838016478543 no 1387 0.435753478501672 2016 3252859
SGTC_1197 1601-0112 267 µM 0.161585805747335 0.426903340158653 no 1388 0.435816017891513 1964 7350313
SGTC_921 1561-0023 372 µM 0.161319627826606 0.427012821886578 no 1389 0.435920832476733 2111 24050882
SGTC_1724 st037281 8.293 µM 0.161100730163111 0.427102860969869 no 1390 0.436007032585078 2009 574124 YDL195W SEC31
SGTC_632 0781-2353 4.65 µM 0.161012673538294 0.427139082335534 no 1391 0.436041709420857 2054 6811515 YHR007C ERG11
SGTC_2715 st079500 56.4 µM 0.160752816232465 0.427245976073071 no 1392 0.436144044497245 2002 28246688
SGTC_148 3253-0744 288.01 µM 0.160601511014316 0.427308218771192 no 1393 0.436203632365427 2157 6893655
SGTC_468 gf-109203x 121 µM 0.160188589373038 0.427478092288367 no 1394 0.436366258842293 2129 2396 A protein kinase C inhibitor.
SGTC_1077 5-fluorocytosine 377 nM 0.159757418314326 0.427655487858168 no 1395 0.436536084212939 2051 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_737 1950-0117 57.9 µM 0.159515315451364 0.427755102013801 no 1396 0.436631446412509 2146 5393513
SGTC_2451 5856223 45.7 µM 0.15918027353208 0.427892963897111 no 1397 0.436763422567019 2007 2179896
SGTC_2536 dehydroabietamide 32.04 µM 0.159098833237539 0.427926475996761 no 1398 0.436795503726869 2113 3983547
SGTC_2502 avocadyne acetate 18.59 µM 0.158737847885063 0.428075025147744 no 1399 0.436937708960964 2137 3952079
SGTC_2561 acetosyringone 100 µM 0.158201728699944 0.428295662461292 no 1400 0.437148920801809 2171 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3262 9137218 49.47 µM 0.157661581348946 0.428517980217562 no 1401 0.437361737713314 2123 17650664
SGTC_1327 1436-0082 2.18 µM 0.1571287767565 0.428737298014065 no 1402 0.437571679350244 2007 15992205
SGTC_1158 4092-0494 91.8 µM 0.154672492948163 0.429748659103625 no 1403 0.438539758216414 2100 1148199
SGTC_2026 5148700 152 µM 0.154362674252582 0.429876258106156 no 1404 0.438661891250565 2037 79838
SGTC_2908 7930301 100 µM 0.15372546464976 0.430138716246887 no 1405 0.438913102774951 2105 2223178
SGTC_720 r052-1644 49.9 µM 0.152168739920391 0.430780040016153 no 1406 0.439526924367973 2047 1422863 YOR257W CDC31
SGTC_1553 gossypol 38.6 µM 0.149609558655372 0.431834741784007 no 1407 0.440536333176534 2127 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_992 3909-8734 162 µM 0.149504687961999 0.431877972003659 no 1408 0.440577705241729 2012 4288319
SGTC_3254 9136651 49.47 µM 0.149452983500865 0.431899286125181 no 1409 0.440598103174728 2125 16454030
SGTC_590 k048-0076 22.4 µM 0.148882443237603 0.432134492993475 no 1410 0.440823197534799 2147 6832814
SGTC_1417 3966-0327 90.4 µM 0.146887501388918 0.432957102101949 no 1411 0.441610408679041 2056 651118
SGTC_111 0083-0039 52.457 µM 0.146672950408136 0.433045589013987 no 1412 0.441695085053466 2167 759313
SGTC_2444 5485484 36.41 µM 0.146315481408956 0.433193026826009 no 1413 0.441836172491592 2104 6790631
SGTC_575 k072-0246 11.9 µM 0.145631573823591 0.433475129877336 no 1414 0.442106120697795 2099 6796779
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.144300638399873 0.434024220601833 no 1415 0.442631537107043 2135 88881 An O-methylated flavonoid and antioxidant.
SGTC_3239 9133757 49.47 µM 0.144232496013443 0.434052336860488 no 1416 0.442658440555652 2091 17036923
SGTC_3090 9117696 49.47 µM 0.143881670261664 0.43419709649873 no 1417 0.442796955040888 2140 7923821
SGTC_2098 5376439 882.5 nM 0.14272614418744 0.434673958277128 no 1418 0.443253234012437 2114 2844116
SGTC_3144 9087057 49.47 µM 0.141877317969946 0.435024311946615 no 1419 0.44358845534926 2210 17249618
SGTC_2808 7946468 45.46 µM 0.141020244519192 0.435378121434495 no 1420 0.443926974673878 2075 2970879
SGTC_1562 morin hydrate 59.1 µM 0.140649676163874 0.435531112225738 no 1421 0.444073351184292 2059 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1616 st002734 56.1 µM 0.140569790734059 0.435564094545329 no 1422 0.444104907362699 2068 4026101
SGTC_3112 9123419 49.47 µM 0.140296744337394 0.435676830669759 no 1423 0.44421276826381 2196 17015854
SGTC_542 3381-0244 89.3 µM 0.13604715670331 0.437432079890919 no 1424 0.44589200091815 2184 1112843
SGTC_844 0330-0132 15.3 µM 0.134980704357572 0.437872762005064 no 1425 0.446313565195146 2167 2828079
SGTC_390 dec-rvkr-cmk 16.7 µM 0.1347861256234 0.437953174646917 no 1426 0.446390487938223 2093 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2439 5492030 7.2 µM 0.134757361392816 0.437965062123188 no 1427 0.446401859462692 2171 5722370
SGTC_1100 amiodarone 5.07 µM 0.132896912022774 0.438734053816674 no 1428 0.447137454545585 2191 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2899 9053889 58.44 µM 0.132301144997871 0.438980355132857 no 1429 0.447373050880182 2204 6470052
SGTC_731 3966-0296 387 µM 0.132189045556151 0.439026701798897 no 1430 0.447417382732539 2134 660956
SGTC_94 0334-0113 514.748 µM 0.130896844297831 0.439561012831486 no 1431 0.447928455544979 2116 6795178
SGTC_104 0074-0074 590.992 µM 0.129718485845571 0.440048347133843 no 1432 0.448394578277009 2191 3943124
SGTC_2324 6149169 200 µM 0.129229637569005 0.440250547066229 no 1433 0.44858797272189 2159 2888231
SGTC_504 lovastatin 124 µM 0.128110143193771 0.44071365669425 no 1434 0.449030904543554 2005 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3100 9120536 49.47 µM 0.126953723829626 0.441192126507877 no 1435 0.44948851256539 2208 16421196
SGTC_1782 st039423 80.636 µM 0.126809086264585 0.441251976517584 no 1436 0.4495457520003 1991 2068169
SGTC_1857 st056007 79.3 µM 0.126706327038261 0.441294498379793 no 1437 0.449586418975849 2190 619834
SGTC_2270 7924575 90.91 µM 0.126426290879677 0.441410381032824 no 1438 0.449697246003998 2209 1262135
SGTC_2688 kanamycin b 96.69 µM 0.126068181541871 0.441558578703404 no 1439 0.449838976966727 2095 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1827 berberine 7.24 µM 0.125796394447316 0.441671058793161 no 1440 0.449946547957874 1960 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2610 ononetin 44.17 µM 0.125456989264333 0.441811529481744 no 1441 0.450080886769384 2064 259632
SGTC_313 3474-0040 5.03 µM 0.12509838927859 0.44195995233411 no 1442 0.450222829224985 2129 1043375 YIL048W NEO1
SGTC_247 mechlorethamine 29.705 µM 0.12454069235954 0.442190796657389 no 1443 0.450443591656797 2095 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.123733506546357 0.442524945254288 no 1444 0.450763140560033 2046 688788
SGTC_3161 9100388 49.47 µM 0.122375399861488 0.443087249282542 no 1445 0.451300860064585 2113 25236368
SGTC_586 0957-0265 8.15 µM 0.121998993072544 0.443243115295974 no 1446 0.451449907863048 2200 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2918 7977171 22.06 µM 0.121337488768238 0.443517058397611 no 1447 0.451711863812779 2159 2236483
SGTC_1425 4048-4433 7.33 µM 0.120715280438795 0.443774752834937 no 1448 0.451958277734233 2189 23734946
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.120034106111087 0.444056895949678 no 1449 0.45222806525136 2207 1241132 A phosphatase inhibitor.
SGTC_2998 9066762 71.4286 µM 0.119985112254383 0.444077190350836 no 1450 0.45224747072612 2153 4945196
SGTC_125 0133-0007 11.75 µM 0.119823242621392 0.444144241580387 no 1451 0.4523115848215 2211 26541
SGTC_1386 3228-0095 33.8 µM 0.119500644891083 0.444277875947626 no 1452 0.452439364574502 2168 870181
SGTC_1444 4112-3581 28 µM 0.119403447023218 0.44431814088196 no 1453 0.452477865252306 2128 2877249
SGTC_3215 9129942 49.47 µM 0.118793005674482 0.444571033839173 no 1454 0.452719675054501 2205 17682944
SGTC_1990 st072050 59.8 µM 0.116153948354427 0.445664597906701 no 1455 0.453765266758778 2104 17233948
SGTC_114 0364-0001 490.298 µM 0.115227013502999 0.446048796739302 no 1456 0.454132593800077 2046 4003655
SGTC_746 1095-0025 46.6 µM 0.114573007535395 0.446319901664676 no 1457 0.454391787826808 2189 6749286
SGTC_1513 0337-0559 19 µM 0.114282007693448 0.446440537828728 no 1458 0.454507122414249 2037 775073
SGTC_462 ag-879 158 µM 0.114194815563299 0.446476684945034 no 1459 0.454541680803495 2201 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1797 st048695 56.8 µM 0.112307952539982 0.447259027492637 no 1460 0.455289618241493 2218 592262 YIL048W NEO1
SGTC_3245 9134821 49.47 µM 0.112237439023984 0.447288268230293 no 1461 0.455317572325163 2165 17014901
SGTC_2277 7947813 106.88 µM 0.112197617485663 0.447304781661312 no 1462 0.455333359107196 2187 1246798
SGTC_1045 1348-1485 165 µM 0.110574465795565 0.447977957231853 no 1463 0.455976898318222 2207 6810614
SGTC_739 1486-1183 203 µM 0.108418655872502 0.448872275442383 no 1464 0.456831801558572 2227 4346692
SGTC_1369 1866-0067 208 µM 0.10813355624524 0.448990565991224 no 1465 0.456944875086236 2196 3531355
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.10726121412222 0.449352537158683 no 1466 0.457290876811703 2202 16486 A toxic proline analog.
SGTC_1053 3366-3204 134 µM 0.107238264650969 0.449362060422822 no 1467 0.457299979821543 2109 3632071 YPR165W RHO1
SGTC_1733 st037357 54.9 µM 0.106977592882151 0.449470232547339 no 1468 0.457403378009255 2206 1272339 YGL099W LSG1
SGTC_2748 diazoxide 86.69 µM 0.106314007673866 0.449745620385051 no 1469 0.457666609030205 2184 3019 A potassium channel activatior.
SGTC_3265 9137266 49.47 µM 0.106224987185746 0.449782565728655 no 1470 0.457701923098162 2255 17224265
SGTC_100 0086-0128 49.5915 µM 0.105803692671803 0.449957417563905 no 1471 0.457869053454787 2054 93297
SGTC_523 1934-0222 13.7 µM 0.105681276067225 0.450008226523798 no 1472 0.457917618340272 2118 1361595
SGTC_705 1124-0212 310 µM 0.105491420527892 0.450087027605699 no 1473 0.457992938715872 2229 9554485
SGTC_2292 7671323 168.05 µM 0.105438008983402 0.450109196855404 no 1474 0.458014128665078 2110 937504
SGTC_3323 9138564 53.9225 µM 0.105212197142148 0.45020292511198 no 1475 0.458103716260613 2212 43912313 YNL103W MET4
SGTC_55 0767-0285 6.563 µM 0.10506021567037 0.450266009986131 no 1476 0.458164013919112 2220 3116166
SGTC_3022 9087993 49.47 µM 0.10335806473855 0.450972628812934 no 1477 0.458839396663726 2229 17173644
SGTC_1371 2421-0008 32.7 µM 0.102580731059414 0.451295377410963 no 1478 0.459147868268764 2122 2827552
SGTC_160 3453-0671 289.699 µM 0.101620048275119 0.451694296941409 no 1479 0.459529132802798 2195 5322268
SGTC_1688 st021091 57.6 µM 0.101265053255373 0.451841719511846 no 1480 0.45967002850649 2237 3656366
SGTC_1093 fluphenazine 7.97 µM 0.100312925480835 0.45223715251083 no 1481 0.460047948101716 2214 6602611 An atypical antipsychotic.
SGTC_1422 4031-0024 15.5 µM 0.100009713755248 0.452363090871552 no 1482 0.460168306824953 2230 782427
SGTC_2373 9071805 200 µM 0.0999257445229014 0.452397968165865 no 1483 0.46020163873318 2268 10149009
SGTC_291 SEC14.278 35.5 µM 0.0989792730225255 0.452791118037331 no 1484 0.460577363506215 2217 1068044
SGTC_2040 5100729 123 µM 0.0979011287680085 0.453239019139436 no 1485 0.461005401833617 2162 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2173 5763948 167 µM 0.0977522166125465 0.453300887459576 no 1486 0.461064525601556 2244 2867177
SGTC_2368 9071271 200 µM 0.0975664875816718 0.453378053622585 no 1487 0.461138268269982 2138 27209959
SGTC_2186 6124449 200 µM 0.0965066173279698 0.453818439063207 no 1488 0.461559109295857 2197 3834182 YLR033W RSC58
SGTC_962 1254-0300 21.5 µM 0.0954246482657235 0.454268065327695 no 1489 0.461988769461174 2173 7340576
SGTC_609 0986-0026 86.3 µM 0.0941645370303891 0.454791794721838 no 1490 0.462489227457541 2196 2848610
SGTC_2341 7987486 176.74 µM 0.0940520898241434 0.454838534037949 no 1491 0.46253388919334 2234 1258686
SGTC_1647 st011722 22.4 µM 0.0935653657575349 0.455040850846138 no 1492 0.462727211500723 2211 2854783
SGTC_2363 9053361 176 µM 0.0933074721810245 0.455148054313225 no 1493 0.462829648020506 2244 6469797 YMR079W SEC14
SGTC_142 0335-0849 62.6745 µM 0.0932761503406367 0.455161074673552 no 1494 0.462842089368187 2225 3889043 YPR107C YTH1
SGTC_2117 5521686 200 µM 0.0932480897101608 0.455172739403227 no 1495 0.462853235361604 2176 803312
SGTC_393 acivicin 6.25 µM 0.0928644302703992 0.455332229487431 no 1496 0.463005632064795 2167 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_64 000l-0018 272.079 µM 0.0925426556873079 0.455465999128502 no 1497 0.46313345113334 2104 6811119
SGTC_2773 thioridazine 9.09 µM 0.0913966952395854 0.455942444095975 no 1498 0.463588693788705 2267 5452 An antipsychotic.
SGTC_1761 st044296 37 µM 0.0911029321785553 0.456064589372334 no 1499 0.463705401396304 2238 1826700
SGTC_1232 0279-0259 161 µM 0.0906481845160909 0.456253679461232 no 1500 0.463886071900198 2155 1560000
SGTC_3007 9078383 71.4286 µM 0.0902152416272078 0.456433712044258 no 1501 0.46405808632435 2156 6496995
SGTC_2202 7226349 200 µM 0.0897567121572017 0.456624394161502 no 1502 0.464240273989776 2232 844334
SGTC_495 decylubiquinone 155 µM 0.0893696959365606 0.456785344857765 no 1503 0.46439405310911 2110 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_937 3122-0005 46.7 µM 0.0892362224169284 0.45684085491549 no 1504 0.464447089434322 2249 759535
SGTC_1529 apigenin 74 µM 0.0889795120125717 0.456947620102195 no 1505 0.464549096285182 2239 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_834 0312-0008 75.7 µM 0.0865342139381505 0.45796476788358 no 1506 0.465520879638784 2256 6385573 YIL048W NEO1
SGTC_1992 st073643 23.3 µM 0.0862403432931594 0.458087025173981 no 1507 0.465637680421273 2257 3161292
SGTC_2531 methyl deoxycholate 70.07 µM 0.0850669319036711 0.458575232085517 no 1508 0.466104089751621 2183 16667744 Haematoxylin.
SGTC_1120 ficusin 1.78878 µM 0.0849459724348576 0.458625561776381 no 1509 0.466152171561796 2171 6199 A DNA cross-linker.
SGTC_2996 9066192 71.4286 µM 0.0847340023642586 0.458713761415955 no 1510 0.466236431594231 2156 6472854
SGTC_2291 7917025 104.35 µM 0.0837910913210103 0.459106126347856 no 1511 0.466611265603497 2193 2964612
SGTC_939 1165-0479 45.3 µM 0.0822605935234938 0.45974308301839 no 1512 0.467219744994869 2278 1377347
SGTC_329 k048-0121 21.3 µM 0.0810965980320217 0.460227579442841 no 1513 0.467682565577835 2156 6832902
SGTC_2990 9074105 71.4286 µM 0.0806157760093275 0.460427731989269 no 1514 0.467873759800157 2278 6502001
SGTC_3012 9080433 71.4286 µM 0.0801443466213887 0.460623984384177 no 1515 0.468061226327916 2254 17688859
SGTC_3015 9080845 49.47 µM 0.0784988332094705 0.46130907370496 no 1516 0.468715629162192 2242 5296973
SGTC_2649 anisomycin 9.56 µM 0.0783229517324894 0.461382306628928 no 1517 0.468785580349415 2200 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2456 5770359 74.46 µM 0.0772263747333297 0.461838925021963 no 1518 0.469221730146631 2267 3118787
SGTC_290 2043-6722 48.1 µM 0.07710319643079 0.461890220040012 no 1519 0.469270725094298 2244 773758 YLR208W SEC13
SGTC_1635 st007035 42.4 µM 0.0758793423572416 0.462399902675195 no 1520 0.46975754594025 2267 3716403
SGTC_1947 st076332 61.6 µM 0.0758372577858825 0.462417430193755 no 1521 0.469774287017642 2267 24208416
SGTC_1511 0906-3109 28.5 µM 0.0756576943728604 0.462492216165025 no 1522 0.469845717238908 2272 2882180
SGTC_2332 7982454 138.89 µM 0.0753428456877998 0.462623350001013 no 1523 0.469970966203829 2260 2981748
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0752025069906854 0.462681802092235 no 1524 0.470026794857491 2272 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1673 st016611 27.3 µM 0.0738040003674654 0.463264334126315 no 1525 0.47058317193811 2235 5226799
SGTC_1496 4469-0713 57.4 µM 0.0726953505990659 0.463726185625438 no 1526 0.47102427422313 2280 746691
SGTC_2801 7907800 81.82 µM 0.0711091425935321 0.464387067580965 no 1527 0.471655445927739 2204 6620925
SGTC_1471 k673-0312 37 µM 0.0706451854052994 0.464580390603489 no 1528 0.471840073736288 2284 24099884
SGTC_185 k048-0037 25.491 µM 0.0701929041804518 0.464768856500956 no 1529 0.472020061020045 2292 6827589
SGTC_3167 9103034 49.47 µM 0.0701839994477647 0.464772567188671 no 1530 0.47202360475469 2257 5127859
SGTC_723 4182-0001 115 µM 0.0694458844304192 0.465080157433382 no 1531 0.472317353279542 2184 744821 YLR208W SEC13
SGTC_2469 5655019 90.81 µM 0.0694067581543744 0.465096462875737 no 1532 0.47233292483252 2266 2788239
SGTC_2969 9091408 28.7 µM 0.0690857418717409 0.465230245067869 no 1533 0.472460685124274 2076 4286311
SGTC_289 k017-0060 526 µM 0.0685047735729381 0.465472371156591 no 1534 0.472691910121688 2271 5512909
SGTC_2767 sibutramine 71.45 µM 0.0678810705186052 0.465732321735437 no 1535 0.472940153764352 2265 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2834 9001755 58.44 µM 0.0673801400918454 0.465941113019271 no 1536 0.473139539581967 2148 2989575
SGTC_664 1222-0054 14.9 µM 0.0669249881418672 0.466130831646277 no 1537 0.473320709985429 2283 6813991
SGTC_398 bronopol 33.3 µM 0.0663805422985762 0.466357780290081 no 1538 0.473537430513628 2180 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_489 paxilline 115 µM 0.0663427546144355 0.466373532242773 no 1539 0.473552472460639 2178 105008 A toxic potassium channel blocker.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0662642378707304 0.46640626244109 no 1540 0.473583727333244 2246 803109
SGTC_145 3737-0113 38.366 µM 0.0654710180868664 0.466736933799667 no 1541 0.473899490514637 2289 6849351
SGTC_1264 0783-0040 158 µM 0.0646141355200896 0.467094170201083 no 1542 0.474240614856214 2242 2855798
SGTC_3047 9092122 49.47 µM 0.0640770216685201 0.46731810779011 no 1543 0.474454449145134 2247 17173831
SGTC_539 4859-0462 2.54 µM 0.0638055670275725 0.467431288661613 no 1544 0.474562522723493 2303 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_568 1193-0097 7.48 µM 0.0636238043071009 0.467507074666688 no 1545 0.474634888521723 2274 3646150
SGTC_2491 paeonol 100 µM 0.0615130126112831 0.468387255264708 no 1546 0.475475325733294 2196 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3160 9100216 49.47 µM 0.0614841840504466 0.46839927758732 no 1547 0.475486804936937 2310 17191039
SGTC_2142 5622915 118.518 µM 0.0614072195728036 0.468431374085443 no 1548 0.475517451412485 2233 5322196
SGTC_981 1488-1094 54.9 µM 0.0612044017553453 0.468515956187463 no 1549 0.475598212106667 2301 3449522
SGTC_1155 4088-0394 48.2 µM 0.0601069856262828 0.468973641531173 no 1550 0.476035213149856 2265 2326248
SGTC_1194 1488-0194 225 µM 0.0596447822406822 0.469166419107091 no 1551 0.476219275382252 2239 1391452
SGTC_2233 sulbentine 40.3845 µM 0.0584793523574892 0.469652533102568 no 1552 0.47668340438785 2279 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0584410832429113 0.469668496354479 no 1553 0.476698645489451 2295 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2982 9019404 25.97 µM 0.0580924097976168 0.469813941262704 no 1554 0.476837510144239 2241 22333232
SGTC_2122 5258151 111.688 µM 0.0574081532637976 0.470099382285086 no 1555 0.477110034175028 2256 2173356
SGTC_2841 9004761 38.96 µM 0.0563973518739177 0.470521071192988 no 1556 0.477512633249078 2237 2991039
SGTC_3177 9107506 49.47 µM 0.054958983711113 0.471121190463246 no 1557 0.478085570316893 2303 8897194
SGTC_454 lyso-paf C-16 6.67 µM 0.0542767796741574 0.471405844212184 no 1558 0.478357324706366 2240 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1193 1488-0126 41.5 µM 0.0538571286318743 0.471580953406822 no 1559 0.47852449672867 2313 1384710
SGTC_2289 7946404 165.07 µM 0.0537947640553011 0.471606976952093 no 1560 0.478549340579774 2277 1246120 YPR165W RHO1
SGTC_1773 st048542 73.5835 µM 0.0532178400002738 0.471847722061747 no 1561 0.478779170745949 2266 3237138
SGTC_72 0744-0168 198.391 µM 0.0527982205800241 0.47202283185884 no 1562 0.478946339648205 2188 677577
SGTC_208 k072-0098 12.366 µM 0.0525875053017508 0.472110766698443 no 1563 0.479030286260277 2325 5948901
SGTC_2144 5628481 200 µM 0.052567072624709 0.472119293652173 no 1564 0.479038426460004 2298 2818399
SGTC_1042 0350-0096 82 µM 0.0524293071759362 0.472176786188079 no 1565 0.47909331123725 2284 3122515
SGTC_2474 5321570 43.32 µM 0.0516931722955089 0.472484001175098 no 1566 0.479386588843284 2287 2841384
SGTC_3152 9099253 49.47 µM 0.0509697130341517 0.47278594213105 no 1567 0.479674827332005 2276 25236131
SGTC_1146 3579-1023 7 µM 0.0508348226632645 0.472842241337993 no 1568 0.479728571132817 2316 X1146
SGTC_414 piperonyl butoxide 100 µM 0.0502799964734549 0.473073814890522 no 1569 0.479949632053196 2293 5794 A potent inhibitor of cytochrome P450.
SGTC_2170 morpholine 200 µM 0.0502358333102473 0.473092248119351 no 1570 0.479967228369297 2273 121171 Reacts with secondary amines.
SGTC_2940 9060638 45.86 µM 0.0499968137571918 0.473192013306168 no 1571 0.480062463700784 2243 4027022
SGTC_265 mycophenolic acid 32.932 µM 0.0498127453200366 0.473268843405669 no 1572 0.480135804998089 2284 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1258 0671-0043 57.1 µM 0.0493617360688797 0.473457098702465 no 1573 0.480315510581305 2266 4298767
SGTC_1728 st035614 33.7865 µM 0.0482601474896492 0.473916936469874 no 1574 0.480754457610012 2195 15945546
SGTC_1931 st074438 57.1 µM 0.0480170435543792 0.474018420411667 no 1575 0.480851329740959 2321 2787313
SGTC_1628 st004252 77.7 µM 0.0475902098070074 0.474196606592731 no 1576 0.481021417316195 2307 692968
SGTC_793 0488-0545 106 µM 0.0468750480180816 0.474495169861941 no 1577 0.481306407512353 2240 292548
SGTC_3252 9135871 49.47 µM 0.0464894183249871 0.474656167167144 no 1578 0.481460083961063 2311 17682838
SGTC_1078 idebenone 36.1 µM 0.0462590278317521 0.474752355327629 no 1579 0.481551897690655 2267 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_547 1120-0019 610 nM 0.0456211866940534 0.475018662021273 no 1580 0.481806091106011 2316 3676939
SGTC_3303 9125618 40.5795 µM 0.0447135586951567 0.475397627333269 no 1581 0.482167813115986 2269 22695467
SGTC_1622 st003707 19.4 µM 0.0438137046120695 0.475773368746828 no 1582 0.482526451437199 2260 10140899
SGTC_2322 7413319 38.22 µM 0.0428091233696321 0.476192865276886 no 1583 0.482926845630465 2281 1840400
SGTC_3305 9127027 53.8275 µM 0.0422281509823768 0.476435481820398 no 1584 0.483158410665971 2266 41905295
SGTC_1342 1486-1464 234 µM 0.0414721807359601 0.476751191281038 no 1585 0.483459735161907 2334 3253938
SGTC_1223 0764-0573 147 µM 0.0411292662073848 0.476894404598653 no 1586 0.483596421639061 2331 1609797
SGTC_35 0133-0054 64.071 µM 0.0410534042683761 0.476926087649452 no 1587 0.483626660633979 2299 99677
SGTC_1778 st046819 58.9 µM 0.0405919963318465 0.477118793623547 no 1588 0.48381058245068 2331 671715
SGTC_2070 5230947 200 µM 0.0404014136661428 0.477198391603991 no 1589 0.483886551614206 2333 2835538
SGTC_1488 4013-0813 75.9 µM 0.0390647826498532 0.477756668858605 no 1590 0.484419369449384 2311 2910057
SGTC_2885 9057732 51.95 µM 0.0377524158021599 0.478304854056518 no 1591 0.484942541995023 2295 6471414
SGTC_685 1278-0033 54.9 µM 0.0365883456986941 0.478791129008135 no 1592 0.485406618047332 2328 3590572
SGTC_3312 9133330 71.43 µM 0.0357523290677863 0.479140383464641 no 1593 0.485739922317619 2316 17617324
SGTC_3243 9134147 49.47 µM 0.0356541387712637 0.479181404516634 no 1594 0.485779069619516 2351 24282180
SGTC_2895 9054447 58.44 µM 0.0345575267256723 0.479639552040113 no 1595 0.486216285008397 2327 2697450
SGTC_674 0498-0004 451 µM 0.0340638800108979 0.479845798806152 no 1596 0.486413105667364 2318 4231473
SGTC_2463 5473429 200 µM 0.0331162687851172 0.480241728093185 no 1597 0.486790934625544 2247 5399405
SGTC_1015 4130-4525 82 µM 0.03307502170619 0.480258962322069 no 1598 0.486807380819866 2330 1363237
SGTC_2406 ethylparaben 405.7 µM 0.0320295867833824 0.480695787663406 no 1599 0.48722422807787 2271 8434 A possible steroid mimic.
SGTC_1241 0364-0022 50.8 µM 0.0319581348777967 0.4807256440355 no 1600 0.487252718678694 2314 4563895
SGTC_1285 0929-0069 65.5 µM 0.0311384954577128 0.481068140277235 no 1601 0.48757954480403 2325 1206237
SGTC_1559 coumarin 343 70.1 µM 0.0309209339648912 0.481159053334933 no 1602 0.487666297507253 2335 108770 A hepatotoxic, DNA x-linker.
SGTC_1421 4029-0249 71.4 µM 0.0305960013621959 0.481294835695742 no 1603 0.487795865554595 2351 2894095
SGTC_722 3534-0461 190 µM 0.0284502810273868 0.482191539913915 no 1604 0.488651510975664 2342 658262
SGTC_2216 7189485 200 µM 0.0270248626169565 0.482787277464565 no 1605 0.489219951885164 2350 731273
SGTC_1362 1611-0397 101 µM 0.0269835070441775 0.48280456213998 no 1606 0.489236444357208 2355 27816
SGTC_524 r073-0010 27.8 µM 0.0266701791153267 0.48293551945753 no 1607 0.489361399143356 2352 2772106
SGTC_166 k072-0058 166.424 µM 0.0264368256577831 0.483033052154304 no 1608 0.48945446088947 2372 5846229
SGTC_846 0335-0850 148 µM 0.025691601205732 0.483344533848874 no 1609 0.489751661457165 2365 6819598
SGTC_1486 3970-0793 4.53 µM 0.0249486237764836 0.483655086474203 no 1610 0.490047971561634 2364 2844330
SGTC_221 trifluoperazine 10.304 µM 0.0231695191100144 0.484398763578623 no 1611 0.49075752615217 2353 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_687 k029-0044 34.9 µM 0.0226097596530658 0.484632757950212 no 1612 0.490980779370673 2367 5829338
SGTC_274 sirtinol 40.1 µM 0.0225038789898029 0.484677019486993 no 1613 0.491023008899134 2341 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2628 lathosterol 100 µM 0.0218034709275817 0.484969817407156 no 1614 0.49130236272319 2349 6710616
SGTC_1136 pergolide 1.05886 µM 0.0211098520011899 0.485259785190558 no 1615 0.491579012943274 2340 47811 A dopamine receptor agonist.
SGTC_2110 5483698 200 µM 0.0195136835855092 0.485927093651477 no 1616 0.492215660599617 2350 2848765 YHR062C RPP1
SGTC_1808 st050063 61.5 µM 0.0192158343816295 0.486051619575934 no 1617 0.492334462962621 2370 4011993
SGTC_2706 st078239 82.5 µM 0.0186717462505296 0.486279097507692 no 1618 0.492551483775386 2373 15434492
SGTC_2294 7971431 200 µM 0.017416308159834 0.486804000820897 no 1619 0.493052249549282 2364 5741572
SGTC_1137 ixabepilone 100 µM 0.016863940544403 0.48703495506174 no 1620 0.493272579975462 2378 154225 A novel microtubule stabilizer.
SGTC_2333 9017922 200 µM 0.0166109525246504 0.487140735087478 no 1621 0.49337349345666 2372 3163164
SGTC_2251 lansoprazole 556 µM 0.0164674316146784 0.48720074483592 no 1622 0.493430742185136 2348 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2416 tofa 880 nM 0.0162339217837534 0.487298381863282 no 1623 0.493523886677698 2342 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2647 atorvastatin 60.16 µM 0.0161545783610319 0.487331557753299 no 1624 0.49355553597334 2355 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1172 0370-0043 85 µM 0.0154821777779424 0.487612712314822 no 1625 0.493823751431568 2353 376585
SGTC_2606 farnesol 9.78 µM 0.0154573491728002 0.487623094155046 no 1626 0.493833655426771 2371 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2047 4141938 200 µM 0.0149912385780228 0.48781799532458 no 1627 0.494019585100131 2360 3807862
SGTC_44 0929-0055 61.211 µM 0.0149691460010844 0.487827233267171 no 1628 0.49402839777429 2354 1379590
SGTC_1897 st060201 15 µM 0.0138536435550898 0.488293685542587 no 1629 0.494473372630385 2362 611878
SGTC_1861 st057647 17.4 µM 0.013738793419919 0.488341711553994 no 1630 0.494519186844943 2382 688668
SGTC_3097 9117246 49.47 µM 0.0132407428522672 0.488549979535879 no 1631 0.494717862194423 2383 16423892
SGTC_350 k064-0020 19.8 µM 0.0129079408211656 0.488689147886157 no 1632 0.494850619647861 2384 2790705
SGTC_1805 st050013 60.3 µM 0.0113294150434079 0.489349260970285 no 1633 0.495480314015044 2371 4037144
SGTC_1398 3558-0053 112 µM 0.0112672344409525 0.48937526446757 no 1634 0.495505118903131 2375 4532369
SGTC_2403 6032726 181.2 µM 0.00752956914323921 0.490938409155543 no 1635 0.496996164899027 2390 2881040
SGTC_1109 tnp00067 928.257 nM 0.00679976216925683 0.491243641784732 no 1636 0.497287308278374 2380 676295
SGTC_3316 9136639 10.545 µM 0.00649104669900523 0.491372759718445 no 1637 0.497410465212161 2350 4903665
SGTC_259 usnic acid 108.925 µM 0.00486508427578114 0.492052820927831 no 1638 0.498059119841141 2397 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2307 7538926 6.34 µM 0.00408655058896614 0.492378452103853 no 1639 0.498369706726685 2391 96582
SGTC_501 nsc-95397 161 µM 0.00323139005395234 0.49273613923575 no 1640 0.498710864126511 2397 262093
SGTC_694 1315-0438 43.2 µM 0.00282934754587219 0.492904303184857 no 1641 0.498871255143975 2399 6793154
SGTC_2111 5486399 200 µM 0.00266883482772467 0.492971441843854 no 1642 0.498935290211744 2401 689674
SGTC_1699 st031318 29.054 µM 0.00266231528133632 0.492974168819538 no 1643 0.498937891125207 2396 5340658
SGTC_567 1080-0542 68.4 µM 0.00265191992901438 0.492978516956009 no 1644 0.498942038256128 2402 5950415
SGTC_2833 9001315 45.46 µM 0.000882795248569613 0.493718512794883 no 1645 0.499647815696153 2399 2989378
SGTC_2595 hexamethylquercetagetin 100 µM 0.000315059732286266 0.493955991953823 no 1646 0.499874309354018 2405 386331
SGTC_1987 st072290 61.9 µM -0.000347834415493874 0.494233277900761 no 1647 0.499861234147879 2410 54697379
SGTC_2095 5432005 200 µM -0.000570340012273927 0.494326351725218 no 1648 0.499772467267235 2406 783734
SGTC_2179 6298986 200 µM -0.000825131335764987 0.494432931009494 no 1649 0.499670820260632 2409 738374
SGTC_2285 7945142 200 µM -0.000883615233180787 0.494457394897042 no 1650 0.499647488569749 2409 2970608
SGTC_2043 5101342 149 µM -0.000897381280958287 0.494463153255105 no 1651 0.499641996713435 2408 678451
SGTC_1403 3909-7815 62.9 µM -0.000988543440694119 0.494501286549869 no 1652 0.499605628289725 2408 6615483
SGTC_2877 9040724 71.43 µM -0.00101399935651844 0.49451193481406 no 1653 0.499595472853707 2406 6463895
SGTC_1463 k081-0032 34.1 µM -0.00157491637110397 0.494746568583277 no 1654 0.499371699531206 2392 977755
SGTC_453 enantio-paf c16 10 µM -0.00198803710364913 0.49491937975954 no 1655 0.499206888466782 2413 13871343 A lipid and platelet activating factor
SGTC_900 1112-0045 141 µM -0.00262072452577844 0.495184038993361 no 1656 0.498954483378184 2409 56211 YIL048W NEO1
SGTC_2072 5231554 129 µM -0.00267100739838575 0.495205072895051 no 1657 0.498934423484539 2409 789545
SGTC_158 k038-0087 26.446 µM -0.00300205606125354 0.49534355467354 no 1658 0.498802354707962 2415 X158
SGTC_2656 pseudo-anisatin 100 µM -0.00302445780794765 0.495352925623626 no 1659 0.498793417744624 2409 6708809 A neurotoxin.
SGTC_582 0987-0078 156 µM -0.00493716787945412 0.496153046733851 no 1660 0.498030362989305 2413 1625765
SGTC_1184 1269-1718 139 µM -0.00603669000869311 0.496613003877018 no 1661 0.497591723748781 2416 5403821
SGTC_927 2425-1185 123 µM -0.0061565455183707 0.496663142667011 no 1662 0.497543909207072 2419 730375
SGTC_984 1492-0255 2.91 µM -0.00734668635851166 0.49716101338897 no 1663 0.497069122555864 2426 1585198
SGTC_2518 prenyletin 46.28 µM -0.00790414088462891 0.497394214489207 no 1664 0.496846736844492 2423 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2723 salbutamol 83.58 µM -0.00806952784248871 0.497463401330843 no 1665 0.496780759098828 2415 9884233 β2-adrenoceptor agonist
SGTC_1558 st069300 45.6 µM -0.00842409584630888 0.497611729123602 no 1666 0.49663931174156 2422 24208000
SGTC_1731 st035964 63 µM -0.00865765089532982 0.497709433284549 no 1667 0.496546140156249 2442 6739575
SGTC_1335 1486-0900 202 µM -0.00901349949735995 0.497858297333785 no 1668 0.496404182645461 2428 X1335
SGTC_250 brefeldin a 552.239 µM -0.0092907778101432 0.497974292861396 no 1669 0.496293569236085 2418 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_480 am 92016 50 µM -0.00931331752635398 0.497983722045999 no 1670 0.496284577579324 2431 2129 K+ channel blocker.
SGTC_3293 9120939 62.045 µM -0.0105041099210046 0.498481875367554 no 1671 0.495809543494597 2428 934087
SGTC_2851 9015922 71.43 µM -0.0105462077335692 0.498499486516469 no 1672 0.495792749827473 2430 2996893
SGTC_1922 5578187 25 µM -0.010796272726012 0.498604098467551 no 1673 0.495692994009426 2429 1350412
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0109728058518027 0.498677949225702 no 1674 0.495622571653452 2424 165506
SGTC_2211 7117706 200 µM -0.0115019290464335 0.498899302555468 no 1675 0.495411495369646 2418 822771
SGTC_1427 4048-4900 550 nM -0.0128881657839008 0.499479222087784 no 1676 0.494858508090135 2446 24132586
SGTC_1888 azatryptophan 97.5 µM -0.013110742391711 0.499572335121968 no 1677 0.494769720373084 2472 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1726 st035556 14.5795 µM -0.0140829716637184 0.499979059189979 no 1678 0.494381892876877 2551 5919439
SGTC_2241 6772625 37.8075 µM -0.0141830850624235 0.499979059189979 no 1679 0.494341957397921 2419 2285411
SGTC_803 4488-1585 147 µM -0.015073835883694 0.499606420946168 no 1680 0.493986637265601 2423 747204
SGTC_3151 9099821 49.47 µM -0.0155372280413644 0.49941256478228 no 1681 0.49380179219526 2456 17174189
SGTC_2701 st077767 14.721 µM -0.016121086122404 0.499168312928115 no 1682 0.493568895703645 2449 5721188
SGTC_401 neomycin 50 µM -0.0161971489007519 0.499136492759846 no 1683 0.4935385550069 2458 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3064 1327-0027 10 µM -0.016725226956742 0.498915576293156 no 1684 0.493327910886588 2429 16000455 YPR107C YTH1
SGTC_3210 9128157 49.47 µM -0.0175027355338608 0.498590313548627 no 1685 0.493017775270492 2485 17590849
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0176826794495741 0.498515035981378 no 1686 0.492945999142845 2439 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1954 st077032 68.9 µM -0.0182237463745312 0.498288686885821 no 1687 0.492730179456657 2477 698907
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.0186998399297502 0.498089519101898 no 1688 0.492540277975407 2428 6708630 An antioxidant.
SGTC_471 1-acyl-paf 4 µM -0.0194655217807942 0.497769206696368 no 1689 0.492234870731038 2440 16759367
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0201039811932136 0.497502117128105 no 1690 0.491980212127628 2460 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1565 sinapyl alcohol 95.1 µM -0.0214484635096693 0.496939677661031 no 1691 0.491443957076839 2458 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1675 st018485 24.5 µM -0.0224059406668017 0.496539138332753 no 1692 0.491062070787842 2492 3323024
SGTC_945 3381-0768 11.3 µM -0.0224527897801933 0.496519540131698 no 1693 0.491043385396394 2446 1126236 YIL048W NEO1
SGTC_536 3852-0578 10.6 µM -0.0224703206122703 0.496512206531427 no 1694 0.491036393370304 2437 2869208
SGTC_2133 5320837 200 µM -0.022877103497625 0.496342039070324 no 1695 0.490874152188741 2460 2841355
SGTC_514 4466-0038 2.65 nM -0.0229638427389596 0.496305753959977 no 1696 0.49083955732638 2500 5722064
SGTC_2592 piperlongumine 83.33 µM -0.0230131502625092 0.496285127450853 no 1697 0.490819891667547 2473 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_211 3455-0679 143.504 µM -0.0236742482407168 0.49600857543373 no 1698 0.490556223587239 2470 748649
SGTC_153 4077-0274 519.67 µM -0.0239702248787722 0.495884762423769 no 1699 0.490438179492441 2449 3121976
SGTC_2195 6536160 144.242 µM -0.0248530819588964 0.495515447864413 no 1700 0.490086075417175 2450 3834386
SGTC_1139 k015-0024 46.9 µM -0.0251628806719904 0.495385854538543 no 1701 0.489962522253664 2443 2766652
SGTC_1917 st066507 28.5 µM -0.026407349400885 0.494865280140828 no 1702 0.489466216110581 2430 3156428
SGTC_1329 1447-1697 50.6 µM -0.0268557458838994 0.494677713258183 no 1703 0.48928739522127 2512 2840515
SGTC_1554 st069299 38.7 µM -0.0279866189283464 0.494204667740398 no 1704 0.488836411757996 2480 24207999
SGTC_2823 7987624 58.44 µM -0.0280375514755208 0.494183362783113 no 1705 0.488816100581901 2478 2239440
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0291321861641882 0.493725483936867 no 1706 0.488379582919356 2449 688798
SGTC_3050 9093513 49.47 µM -0.0291594323755465 0.493714087119949 no 1707 0.488368717869457 2456 25236664
SGTC_2917 7979103 53.79 µM -0.0292651895133202 0.493669850018708 no 1708 0.488326544873959 2462 2980565
SGTC_883 0850-0245 24.6 µM -0.0296324942054054 0.493516210927549 no 1709 0.488180075028927 2588 6823229 YPR165W RHO1
SGTC_2555 cholic acid 100 µM -0.0302280944882194 0.493267080618145 no 1710 0.487942571301824 2573 6708657 Influences liver metabolism.
SGTC_1600 coumarin 106 71.1 µM -0.0312049682810273 0.492858475276546 no 1711 0.48755303886505 2588 100336 A hepatotoxic, DNA x-linker.
SGTC_533 1222-0222 6.71 µM -0.0318169769382863 0.492602488980861 no 1712 0.487309003925781 2599 3982874
SGTC_3181 9108277 49.47 µM -0.0337696537571685 0.491785759151356 no 1713 0.486530417465508 2464 17097298
SGTC_1901 st060216 58.6 µM -0.0342631238523249 0.491579364850651 no 1714 0.486333665247809 2462 688792
SGTC_788 1182-0090 188 µM -0.0348239067791516 0.491344819638761 no 1715 0.486110078668741 2609 5715185
SGTC_1935 st074532 41.6 µM -0.0348715711137338 0.491324884358677 no 1716 0.486091074892674 2600 2829742
SGTC_1407 3909-7909 12.3 µM -0.0373239092606547 0.490299241163838 no 1717 0.485113370969423 2484 4411780
SGTC_2894 9048625 32.47 µM -0.0382385947980182 0.489916707615976 no 1718 0.484748724593207 2479 4092861
SGTC_3279 9140807 49.47 µM -0.0383173553434942 0.48988376934642 no 1719 0.48471732669218 2474 45595718
SGTC_3133 9127736 49.47 µM -0.0384873426285973 0.48981267958388 no 1720 0.484649561563517 2466 27243420
SGTC_1277 0873-0036 22 µM -0.0388471406748996 0.489662210825356 no 1721 0.484506130177423 2510 5965735
SGTC_1846 st056244 14.8 µM -0.0399783921828971 0.489189127307539 no 1722 0.484055176529261 2528 5393182
SGTC_1863 st057641 20.1 µM -0.0400784330414008 0.489147291461247 no 1723 0.484015297962045 2467 3921635
SGTC_589 1227-0070 34.1 µM -0.0404480329646916 0.488992730396269 no 1724 0.483867968395099 2516 2841384
SGTC_440 fluspirilene 35.1 µM -0.0404612242353039 0.488987214037999 no 1725 0.483862710144047 2694 3396 An atypical antipsychotic.
SGTC_2611 pyromycin 23.93 µM -0.0427013285720282 0.488050473065168 no 1726 0.482969810245005 2504 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_139 0099-0334 718.624 µM -0.0429417961601542 0.487949920931472 no 1727 0.482873965472181 2497 97690
SGTC_2818 7996756 12.99 µM -0.0430943966676371 0.487886111037944 no 1728 0.48281314298157 2476 2241621
SGTC_2685 mycophenolic acid 18.85 µM -0.0433632875082647 0.48777367510385 no 1729 0.482705971241223 2518 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_597 k018-0003 82.8 µM -0.0437710792148833 0.487603160028175 no 1730 0.482543440212229 2539 6786234
SGTC_1826 st055655 41.6 µM -0.045346129071039 0.486944586178933 no 1731 0.481915709774839 2524 676168
SGTC_2659 sanguinarine 24.21 µM -0.0455248195897694 0.486869872725664 no 1732 0.481844496115964 2485 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2973 9094665 17.96 µM -0.0468820353621965 0.486302413655956 no 1733 0.481303623026629 2528 25237061 YIL048W NEO1
SGTC_3282 9108498 15.4605 µM -0.0474827394873408 0.486051264880249 no 1734 0.48106424335588 2545 16459645
SGTC_624 k048-0052 28 µM -0.0475657640250572 0.486016553530568 no 1735 0.481031158740291 2527 6835531
SGTC_1022 4477-0945 21.3 µM -0.0479098477407803 0.485872698274132 no 1736 0.480894045521339 2491 4648966
SGTC_3113 9123498 49.47 µM -0.0479466269438481 0.48585732165461 no 1737 0.480879389585059 2480 8897275
SGTC_938 3126-1755 342 µM -0.0480577261062554 0.485810873534286 no 1738 0.480835118466227 2485 1777771
SGTC_1247 0448-0043 5.84 µM -0.0480993400879751 0.485793475691797 no 1739 0.48081853606603 2529 3089013 YGL099W LSG1
SGTC_3072 9116419 49.47 µM -0.0487712802312433 0.485512556838367 no 1740 0.480550784991519 2517 17170162
SGTC_1788 fluconazole 20 µM -0.0500157204728459 0.484992311247083 no 1741 0.480054930437357 2584 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1475 4092-1048 11.7 µM -0.0501369657280461 0.484941625303618 no 1742 0.480006621187885 2528 2881759
SGTC_2626 ethyl orsellinate 100 µM -0.0503752619833942 0.484842007512806 no 1743 0.479911674714391 2508 75653 A natural product.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0506573312805564 0.484724091984828 no 1744 0.479799288836194 2540 5393153
SGTC_979 1426-2828 121 µM -0.0525289255612209 0.483941729823278 no 1745 0.479053623939669 2569 747872
SGTC_1201 1889-3372 45.9 µM -0.0550986135629716 0.482867652468441 no 1746 0.478029950342543 2559 5392199
SGTC_1629 st005085 44.9 µM -0.0552618089646732 0.482799444223943 no 1747 0.477964943839994 2513 24207091
SGTC_2738 aclarubicin 5.55 µM -0.0552644224707713 0.482798351901527 no 1748 0.477963902792811 2565 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1619 st003326 88.7 µM -0.0558983162493546 0.482533418000537 no 1749 0.477711406086446 2508 2849032
SGTC_971 1315-0384 26.7 µM -0.0562227921161013 0.482397807314766 no 1750 0.477582162197376 2539 6769120
SGTC_2100 5377183 190 µM -0.0574255449170275 0.48189514950761 no 1751 0.477103107336479 2567 2844202
SGTC_2274 7947094 46.08 µM -0.0574378726399108 0.4818899976189 no 1752 0.477098197390766 2503 2971028
SGTC_2326 6164455 177.58 µM -0.0575779209074776 0.481831470145885 no 1753 0.477042418526647 2556 2888790
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0581667464473112 0.481585398777535 no 1754 0.476807904173973 2498 17037758
SGTC_2192 5915882 198.485 µM -0.0586128666259379 0.481398968930703 no 1755 0.476630231108916 2501 2876149
SGTC_1103 duloxetine 36.1 µM -0.0587795642337081 0.481329308453096 no 1756 0.476563842845709 2626 60835 A selective serotonin reuptake inhibitor.
SGTC_2829 7992743 58.44 µM -0.0588279062598699 0.481309107138177 no 1757 0.47654459048252 2512 16462845
SGTC_1354 1498-1681 81 µM -0.0589626833878133 0.481252786310069 no 1758 0.476490915358827 2564 5754243
SGTC_3301 9125354 19.7965 µM -0.0596351381232471 0.480971785730849 no 1759 0.476223115991996 2518 41905162
SGTC_2602 kawain 100 µM -0.0606200627405416 0.480560229574376 no 1760 0.475830897575354 2492 5369129
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0606455987020893 0.480549559506384 no 1761 0.475820728909549 2589 6708760
SGTC_2526 patulin 37.61 µM -0.0607746177873687 0.480495649769538 no 1762 0.475769352508226 2580 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_513 4245-1575 41.7 µM -0.0616287033665609 0.480138785031811 no 1763 0.475429259200829 2638 719745
SGTC_2745 rifampicin 24.3 µM -0.0619359141948637 0.480010426232103 no 1764 0.475306933497716 2547 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1473 k844-0725 134 µM -0.0626515519183434 0.479711426606035 no 1765 0.475021988760469 2507 54682906
SGTC_1270 0831-1170 17.3 µM -0.0651954378734955 0.478648662639684 no 1766 0.474009196726339 2513 6764716
SGTC_1206 3978-0017 132 µM -0.0651964691000621 0.478648231852513 no 1767 0.474008786199863 2758 3873677
SGTC_1352 1496-0991 99 µM -0.0655480103899448 0.478501379569683 no 1768 0.473868840866718 2526 3000039
SGTC_1380 2291-0730 164 µM -0.0657693162274514 0.478408933127265 no 1769 0.473780742714442 2578 2999191
SGTC_389 tpck 16.7 µM -0.0664905272651444 0.47810766857125 no 1770 0.473493649584477 2559 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2532 xanthone 78.9 µM -0.067109900494851 0.47784895372189 no 1771 0.473247106105438 2567 7020 An insecticide.
SGTC_2078 5212016 200 µM -0.0672590857507385 0.477786639792747 no 1772 0.473187723968893 2502 1899708
SGTC_1578 josamycin 24.2 µM -0.0674011392773248 0.477727305255702 no 1773 0.473131181120561 2532 5282165 A P450 substrate.
SGTC_3189 9110682 49.47 µM -0.0676462523566181 0.477624924790987 no 1774 0.473033617821181 2574 17122418
SGTC_2136 5328288 199.296 µM -0.0692913403969236 0.476937831999063 no 1775 0.472378859266918 2534 262395
SGTC_1233 0325-0408 14.2 µM -0.0697825739301301 0.476732675012085 no 1776 0.472183358675415 2592 12874
SGTC_777 1315-0167 517 µM -0.0700345426050977 0.476627446120133 no 1777 0.472083083051367 2597 4221767
SGTC_1794 st048918 76.9 µM -0.0700803237069785 0.476608326876078 no 1778 0.472064863799534 2510 672303
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0707648231690147 0.476322470559106 no 1779 0.471792464327315 2510 756377
SGTC_1039 k821-0043 94 µM -0.0708904760175024 0.476269997534069 no 1780 0.47174246167142 2511 15992768
SGTC_1446 4239-0190 62 µM -0.0715731993104137 0.475984897353531 no 1781 0.471470784605643 2548 1340085
SGTC_3196 9111891 49.47 µM -0.0722093779105762 0.475719244953589 no 1782 0.471217641082479 2506 18891510
SGTC_3224 9130643 49.47 µM -0.0723743705961383 0.475650349859285 no 1783 0.471151990297933 2616 17644395
SGTC_3052 9092717 49.47 µM -0.072414120742292 0.475633751716666 no 1784 0.471136173784926 2628 25237534
SGTC_510 ag-490 170 µM -0.0724754820979914 0.475608129641492 no 1785 0.471111758299173 2531 5328779
SGTC_2956 9076196 2.52 µM -0.072620798425172 0.475547451693284 no 1786 0.47105393783395 2542 16423868
SGTC_571 k831-0106 44.2 µM -0.0730484211132884 0.475368897851424 no 1787 0.470883792963039 2553 4783639
SGTC_3200 9114385 49.47 µM -0.0732571660469845 0.475281738204454 no 1788 0.470800738307371 2591 17018030 YLR208W SEC13
SGTC_1424 4048-1941 275 µM -0.0737318298051645 0.475083550854941 no 1789 0.470611885594797 2620 X1424
SGTC_3280 9140961 49.47 µM -0.0743307592129587 0.474833487412788 no 1790 0.470373601204694 2538 4901226
SGTC_1955 wogonin 32.4 µM -0.0751738994132096 0.474481478542352 no 1791 0.470038175415518 2766 5281703 A flavanone.
SGTC_1221 2958-7315 257 µM -0.0753593767223707 0.474404044905204 no 1792 0.46996438997096 2605 4562705
SGTC_1670 st016595 4.04 µM -0.0763297975054315 0.473998926484906 no 1793 0.469578360003835 2530 597879
SGTC_550 4123-0385 25.7 µM -0.0765926515184718 0.473889198281881 no 1794 0.469473802510134 2564 5731123
SGTC_355 1311-2252 105 µM -0.0767111200019067 0.473839744352841 no 1795 0.469426679063948 2571 5338538
SGTC_2997 9067075 71.4286 µM -0.0771595317713214 0.47365256131555 no 1796 0.469248317299074 2605 27209819
SGTC_58 0957-0393 9 µM -0.0773059563822046 0.473591439727712 no 1797 0.469190076291038 2542 6997992
SGTC_2350 9023895 38.85 µM -0.0776498084171763 0.473447909046828 no 1798 0.469053310284415 2623 2997209
SGTC_2208 7283366 200 µM -0.0782706176515126 0.473188779662805 no 1799 0.468806394729045 2546 898663
SGTC_2935 9038016 29.96 µM -0.0788674713097481 0.472939660171378 no 1800 0.468569018378307 2563 6463195
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0793405022732435 0.47274223028701 no 1801 0.468380895833332 2551 688669
SGTC_1085 doxorubicin 7.67 µM -0.0796910804327116 0.472595913093463 no 1802 0.46824147683758 2555 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_455 paf C-16 10 µM -0.0802551692847863 0.472360492912504 no 1803 0.468017156438816 2547 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1387 3342-1166 1.8 µM -0.0817777019885949 0.471725118533274 no 1804 0.467411743953814 2623 3418228
SGTC_825 1988-2224 89.6 µM -0.0840951272541656 0.470758162918077 no 1805 0.466490399405054 2554 1180859
SGTC_1225 1216-0074 20.6 µM -0.0845638265474367 0.470562616904544 no 1806 0.466304079125784 2583 4241466
SGTC_648 0375-0473 33.3 µM -0.0854229623519448 0.470204195353635 no 1807 0.465962569282164 2568 1713139
SGTC_1956 st077085 54 µM -0.0855862952698354 0.470136057465606 no 1808 0.465897646635894 2597 24208685
SGTC_3132 9126706 49.47 µM -0.0860478711319599 0.46994350576423 no 1809 0.46571418132757 2758 850858
SGTC_2132 5317594 122.667 µM -0.0861032823667073 0.469920390799359 no 1810 0.465692157183029 2571 794577
SGTC_394 menadione 8.33 µM -0.0877539284628615 0.469231865592869 no 1811 0.465036128096893 2550 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1331 1472-0049 76.2 µM -0.088072742383327 0.469098890978985 no 1812 0.464909430300294 2560 24051409
SGTC_1246 0422-0085 105 µM -0.0881762515437407 0.469055718916297 no 1813 0.464868296152707 2583 264295
SGTC_2181 6316240 54.2555 µM -0.0885699910260873 0.468891499623989 no 1814 0.464711829010438 2617 12779990
SGTC_990 3985-0011 41.3 µM -0.0890612107467507 0.468686631086117 no 1815 0.464516632094316 2628 5399565 YGL099W LSG1
SGTC_2102 5377816 72.7585 µM -0.0893243713549915 0.468576880493882 no 1816 0.464412062971985 2647 1379702
SGTC_1524 corynanthine 62.1 µM -0.0899325557345966 0.468323247595571 no 1817 0.464170405114752 2746 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2497 7-hydroxyflavone 100 µM -0.0905186863100599 0.468078824024187 no 1818 0.463937522690087 2718 5281894
SGTC_2347 9049783 174.81 µM -0.0908008806064514 0.467961149859648 no 1819 0.463825405160397 2641 6467988 YPL169C MEX67
SGTC_1428 4049-0204 61.7 µM -0.0910011830698944 0.467877626038901 no 1820 0.463745825502375 2652 X1428
SGTC_129 0088-0017 176.636 µM -0.0910407160532831 0.467861141407031 no 1821 0.463730119320167 2558 182446
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0911393914386176 0.467819995564902 no 1822 0.463690916515413 2857 5282309
SGTC_1334 1486-0610 236 µM -0.0913240247739776 0.467743007743826 no 1823 0.463617564370931 2686 3742339
SGTC_1478 0453-0656 35.7 µM -0.0921628507713835 0.467393251981918 no 1824 0.463284326587121 2582 5258496
SGTC_1132 3456-3614 2.5 µM -0.0956352201715392 0.465945688266983 no 1825 0.461905145870037 2757 3125502
SGTC_1170 0310-0127 64.8 µM -0.0959333582498561 0.465821420988029 no 1826 0.461786750350813 2650 774975
SGTC_2860 9025725 38.96 µM -0.0985066114172518 0.464749000127155 no 1827 0.460765011171465 2598 40546248
SGTC_1188 1403-0014 4.57 µM -0.0989435798795332 0.464566915745503 no 1828 0.460591533454188 2596 9614867
SGTC_2910 7948405 25.97 µM -0.0995469998274977 0.464315483379204 no 1829 0.460351986362279 2630 2971328
SGTC_2658 polymyxin b sulfate 77.05 µM -0.10012324176885 0.464075388814947 no 1830 0.460123241890449 2608 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1996 st072960 66.8 µM -0.100806624424348 0.463790670410854 no 1831 0.45985198405096 2566 1719405
SGTC_1426 4048-4480 71.7 µM -0.100839853536209 0.463776826604096 no 1832 0.459838794760665 2616 14224343
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.101165884035023 0.463640999144906 no 1833 0.459709389167588 2716 61125 An anti-inflammatory.
SGTC_3116 9124943 49.47 µM -0.101353495134302 0.463562840466394 no 1834 0.45963492590364 2593 41905195 YPL160W CDC60
SGTC_279 1273-0055 2.93 µM -0.101639903934836 0.463443525434327 no 1835 0.459521252343163 2609 2847562
SGTC_2922 7999257 32.47 µM -0.102395069215968 0.463128946949367 no 1836 0.459221548649076 2583 2988377
SGTC_2552 juarezic acid 87.02 µM -0.103008228293525 0.462873540804692 no 1837 0.458978220230934 2570 1549512
SGTC_1804 st050076 49.1 µM -0.103511215990879 0.462664037023616 no 1838 0.458778624119375 2670 3895976
SGTC_1567 st069303 68.4 µM -0.103782471823205 0.462551058192259 no 1839 0.458670988402279 2673 5581319
SGTC_952 1185-0122 232 µM -0.10414789223653 0.46239886432099 no 1840 0.458525992484347 2566 678600
SGTC_2385 9074692 200 µM -0.104438618006631 0.462277783936868 no 1841 0.458410638748188 2619 17046906
SGTC_2295 7971645 200 µM -0.106087402440658 0.461591170800563 no 1842 0.457756503067437 2674 2978226 YKL099C UTP11
SGTC_1143 3454-2408 5.08 µM -0.107026907591446 0.461199978129183 no 1843 0.457383816591869 2569 X1143
SGTC_1963 st076565 50.3 µM -0.109942716795366 0.459986129514671 no 1844 0.456227402380124 2606 4914280
SGTC_2800 7887935 81.82 µM -0.109955160506201 0.459980950000576 no 1845 0.456222467973518 2704 2961002
SGTC_601 0986-0029 62.9 µM -0.110331221392871 0.459824423320456 no 1846 0.456073348657724 2620 24747981
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.110392243572225 0.459799024830692 no 1847 0.456049152133284 2704 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2308 7584454 197.62 µM -0.111399216511085 0.459379928989418 no 1848 0.455649890664332 2660 893577
SGTC_2582 agaric acid 100 µM -0.11203018078558 0.459117348575103 no 1849 0.455399738195542 2646 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1672 st016598 6.51 µM -0.112795069955314 0.458799058257997 no 1850 0.455096513502853 2666 4665860 YNL267W PIK1
SGTC_560 2332-1943 155 µM -0.112999106871414 0.458714157633893 no 1851 0.455015631646406 2592 21177716
SGTC_2231 micatex 6.853 µM -0.113080386320348 0.458680337435592 no 1852 0.454983412345554 2628 20737 An antifungal of unknown mechanism.
SGTC_2863 9028737 58.44 µM -0.113929379673408 0.458327091109709 no 1853 0.454646887791608 2732 6460917
SGTC_2321 7390090 138.78 µM -0.115153878146932 0.457817663897861 no 1854 0.454161577655463 2693 649046
SGTC_2425 5628681 7.85 µM -0.115479309527219 0.457682286536941 no 1855 0.454032609678853 2688 5714958
SGTC_336 4111-0029 111 µM -0.116104434328131 0.457422252427662 no 1856 0.453784887249421 2661 3131175
SGTC_1689 st020265 53.493 µM -0.116181050694277 0.457390383453517 no 1857 0.453754527199118 2669 5758320 YPR016C TIF6
SGTC_503 tyrphostin 8 294 µM -0.116953717937047 0.457069003862812 no 1858 0.453448364717854 2602 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1821 st053465 65.6 µM -0.117941014375204 0.456658393294395 no 1859 0.453057197622798 2703 675086
SGTC_2309 7664088 163.95 µM -0.118074620916867 0.45660283069343 no 1860 0.453004266168149 2648 704922
SGTC_1656 st012921 11 µM -0.119291434425097 0.456096836847462 no 1861 0.452522234690731 2711 6732821
SGTC_2710 st078562 53.7235 µM -0.119654963900279 0.455945682282675 no 1862 0.452378238777396 2597 17250908
SGTC_45 0kpi-0036 14.9 µM -0.120582768642864 0.455559932552485 no 1863 0.452010758935789 2708 2795021
SGTC_936 3005-4620 401 µM -0.120997367157573 0.455387570078838 no 1864 0.451846560288792 2677 777207
SGTC_2279 7948423 32.93 µM -0.121555214703492 0.455155667446578 no 1865 0.451625641934758 2603 1247112
SGTC_2614 arthonioic acid 13.39 µM -0.1216139849306 0.455131236981852 no 1866 0.451602368665864 2610 6710684
SGTC_2393 9031399 185.94 µM -0.12264927838778 0.454700899013003 no 1867 0.451192415241516 2724 1526623 YDL150W RPC53
SGTC_830 4076-0286 57.8 µM -0.123598963476114 0.45430619240696 no 1868 0.450816406610151 2652 6866659
SGTC_2431 5490079 200 µM -0.123604216798751 0.454304009154483 no 1869 0.450814326785579 2663 5722345
SGTC_345 1362-0200 395 µM -0.124374331649879 0.453983968558022 no 1870 0.450509447951172 2646 1419823
SGTC_198 3454-2873 16.191 µM -0.125529564664217 0.453503938509435 no 1871 0.450052160465774 2654 710957
SGTC_901 1112-0062 60.1 µM -0.126347021345309 0.453164304508824 no 1872 0.44972861840464 2624 1908457
SGTC_146 3448-8650 53.125 µM -0.126607573384906 0.45305605845987 no 1873 0.449625501244384 2664 2891488 YIL048W NEO1
SGTC_2094 5332512 191.667 µM -0.127096951498786 0.452852756313025 no 1874 0.449431832123897 2744 755774
SGTC_2881 9058953 51.95 µM -0.129066231272222 0.452034784694271 no 1875 0.448652621007633 2617 17122249
SGTC_1981 st071826 47 µM -0.130117308124886 0.451598286333464 no 1876 0.448236808315435 2726 11838600
SGTC_695 3505-6186 243 µM -0.130412146706196 0.451475854243239 no 1877 0.448120178489504 2746 1819379
SGTC_2191 5911152 200 µM -0.130935306077377 0.451258623026982 no 1878 0.447913242443949 2656 2875902
SGTC_2506 ethyl hematommate 54.16 µM -0.131546113707628 0.451005016139401 no 1879 0.447671655009484 2702 3940691 An allergen.
SGTC_399 oxolinic acid 75 µM -0.131805580162662 0.450897291900541 no 1880 0.447569036366035 2629 4628 A DNA gyrase inhibitor.
SGTC_2382 9035899 200 µM -0.132392313258378 0.450653707762713 no 1881 0.447336997145564 2669 6462679
SGTC_2134 5324836 1.464 µM -0.133235308048443 0.450303768311289 no 1882 0.447003643987976 2690 699272
SGTC_1712 st032288 53.4 µM -0.133472793360293 0.450205191652404 no 1883 0.446909739743265 2672 2883011
SGTC_2019 4016004 108 µM -0.133778968408303 0.450078107428927 no 1884 0.446788679231763 2723 45595336
SGTC_319 1348-1596 45.5 µM -0.134735386085566 0.449681159716574 no 1885 0.446410547113756 2820 5380505
SGTC_3032 9089427 49.47 µM -0.134796074902246 0.449655973370831 no 1886 0.446386554644324 2742 17173707
SGTC_2112 5488546 200 µM -0.13637844937426 0.448999347150013 no 1887 0.445761054700656 2649 600757
SGTC_2654 protoveratrine a 100 µM -0.136569672698084 0.448920006045701 no 1888 0.445685474763961 2650 5702278 A heart drug and vasodilator.
SGTC_1006 4099-6547 255 µM -0.137261391337238 0.448633019849254 no 1889 0.445412093389082 2744 3146833
SGTC_65 0798-0905 34.986 µM -0.138404174810275 0.44815895093336 no 1890 0.444960498875297 3020 3602145
SGTC_1989 st071868 50.2 µM -0.138436211505798 0.448145661988929 no 1891 0.44494783993925 2770 16414057
SGTC_2995 9067767 71.4286 µM -0.138575189828594 0.448088013920461 no 1892 0.4448929248851 2728 11673567
SGTC_3274 9138298 49.47 µM -0.140353842755026 0.447350327692702 no 1893 0.444190212462962 2635 17015756
SGTC_1382 3002-2117 298 µM -0.140817225424243 0.447158172151711 no 1894 0.444007167371496 2722 1497314
SGTC_3138 9097216 49.47 µM -0.140904646406559 0.447121921805189 no 1895 0.443972635735441 2596 25237486
SGTC_367 0335-0881 7.1 µM -0.141196742042664 0.447000803424836 no 1896 0.443857259882716 2779 23828853
SGTC_3029 9088683 49.47 µM -0.141549441941896 0.446854561883674 no 1897 0.443717952087703 2790 25236615
SGTC_2815 7968870 71.43 µM -0.141648811642639 0.446813361082933 no 1898 0.443678704752236 2677 2977326 YHR190W ERG9
SGTC_387 norethindrone acetate 66.7 µM -0.141839083917764 0.446734471735292 no 1899 0.443603555823184 2710 541197
SGTC_583 1488-1091 88.9 µM -0.141919021364826 0.446701329263866 no 1900 0.443571984757734 2652 4303273
SGTC_897 1000-0139 31.4 µM -0.14219200184802 0.446588152977184 no 1901 0.443464174599952 2764 6151020
SGTC_634 1611-4317 11.2 µM -0.142368923161479 0.446514804644903 no 1902 0.443394304019683 2638 2843522
SGTC_1416 3966-0321 25.3 µM -0.143090980453407 0.446215471932238 no 1903 0.443109164097908 2713 582530 YLR208W SEC13
SGTC_1066 ketoconazole 628 nM -0.143171143415656 0.446182241834481 no 1904 0.443077509614103 2809 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_569 4130-2812 160 µM -0.14532810119087 0.445288256884431 no 1905 0.442225914350956 2647 743552
SGTC_541 4513-1321 94 µM -0.145977568456775 0.44501912927709 no 1906 0.441969548248301 2691 747515
SGTC_1642 st009582 77.7 µM -0.146590769178329 0.44476505313098 no 1907 0.441727520048822 2742 6739311
SGTC_2882 9058044 58.44 µM -0.146991027646167 0.444599220600453 no 1908 0.441569551147851 2750 18076804
SGTC_686 1319-0111 510 µM -0.147792040392313 0.444267379267467 no 1909 0.441253445600562 2793 4562600
SGTC_1269 0831-0796 3.05 µM -0.148058383763777 0.444157047919091 no 1910 0.441148346168276 2755 927758
SGTC_1440 4100-1550 40 µM -0.149167217506405 0.443697765947416 no 1911 0.440710843592147 2677 742806
SGTC_2563 tomatine 8.54 µM -0.149243373624515 0.443666224642817 no 1912 0.440680798005733 2644 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2400 5203494 178.7 µM -0.149596508981269 0.443519972513747 no 1913 0.440541481309372 2640 6777674
SGTC_1893 st059353 36.1 µM -0.149878950831357 0.443403003861034 no 1914 0.440430059458217 2719 3112488
SGTC_2957 9076800 11.52 µM -0.151208123889997 0.442852615047451 no 1915 0.439905771021854 2718 16459615
SGTC_2362 9071156 126 µM -0.151591959877762 0.442693695316979 no 1916 0.439754387602334 2837 653133
SGTC_3107 9121808 49.47 µM -0.151664140390802 0.442663811426428 no 1917 0.439725920872225 2659 662681
SGTC_2893 9048488 25.97 µM -0.151669216731062 0.442661709752385 no 1918 0.439723918864265 2687 6467338
SGTC_1832 st054113 55 µM -0.151807818384412 0.442604327402821 no 1919 0.439669257715722 2675 1251267
SGTC_614 0462-0418 107 µM -0.153906844185763 0.441735459436068 no 1920 0.438841593763171 2701 5188303
SGTC_2930 9013230 14.89 µM -0.155276031664509 0.441168850556349 no 1921 0.438301855191453 2780 2995857
SGTC_1908 st060353 56.5 µM -0.155655871675368 0.44101168319628 no 1922 0.438152141197075 2834 4227716
SGTC_2005 4024620 188 µM -0.156282543619243 0.440752403882845 no 1923 0.437905157719456 2683 236743
SGTC_2650 prasterone 100 µM -0.156525406784254 0.440651928474688 no 1924 0.437809447168715 2676 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_515 4092-1064 102 µM -0.157340138711318 0.440314892035683 no 1925 0.437488394037408 2862 717353
SGTC_268 camptothecin 39.6153 µM -0.157791961253545 0.440128001743218 no 1926 0.437310366645514 2678 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1514 1189-1591 158 µM -0.163296803085305 0.43785208179613 no 1927 0.435142375443626 2894 767698 YMR146C TIF34
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.164318080987145 0.437430068684017 no 1928 0.434740374292331 2676 4620898
SGTC_2099 5377090 177.372 µM -0.164781732214173 0.437238501887053 no 1929 0.434557891528117 2777 2243829
SGTC_2747 doxorubicin 7.63 µM -0.166054160868546 0.436712848213315 no 1930 0.434057163782116 2679 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.169496577075377 0.435291312424111 no 1931 0.432703032253906 2718 77254
SGTC_2977 9011197 71.43 µM -0.170936054095837 0.434697131337826 no 1932 0.432137023393628 2932 2704722
SGTC_2334 9017922 200 µM -0.171188946215211 0.434592758815876 no 1933 0.432037599420107 2860 3163164
SGTC_1075 aripiprazole 15.2 µM -0.171795502870727 0.434342442015447 no 1934 0.431799150575745 2698 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2171 5739187 198.077 µM -0.172997127869642 0.433846627285785 no 1935 0.431326842606926 2670 2262761
SGTC_893 0958-0369 48.9 µM -0.174541335276346 0.433209609046076 no 1936 0.430720024219167 2864 6819948
SGTC_358 0075-0058 9.45 µM -0.176295047868686 0.432486375961777 no 1937 0.430031076166636 2632 1069125
SGTC_502 l-744,832 89.3 µM -0.176436381273639 0.43242809971821 no 1938 0.429975562418366 2851 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1199 1638-0010 4.46 µM -0.177425117147478 0.432020453752715 no 1939 0.429587239827315 2715 3111136
SGTC_264 promethazine 12.5 mM -0.177449953401526 0.43201021494216 no 1940 0.429577486349993 2734 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3140 9094243 49.47 µM -0.177683404788364 0.431913976231601 no 1941 0.429485809456895 2679 19291112
SGTC_1974 st069448 26.9 µM -0.177816705446949 0.431859025774082 no 1942 0.429433463688933 2847 6323587 YNR016C ACC1
SGTC_1320 1313-0481 95.3 µM -0.178918038122566 0.431405074548416 no 1943 0.429001029475567 2814 6813365 YLR208W SEC13
SGTC_2742 clothiapine 36.27 µM -0.179231351430318 0.431275948477704 no 1944 0.428878023705817 2746 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1111 tnp00062 510.699 nM -0.179932668605384 0.4309869406944 no 1945 0.428602713951428 2863 676306
SGTC_1209 2323-2347 50.3 µM -0.180519618549445 0.43074509122468 no 1946 0.428372327006746 2713 5412760
SGTC_599 1935-0052 86.5 µM -0.180533842053854 0.4307392308305 no 1947 0.428366744363563 2719 9557311
SGTC_3292 9120825 59.784 µM -0.181614576978387 0.430293989158933 no 1948 0.427942604164213 2772 24824900
SGTC_1652 st011932 78 µM -0.18202713851186 0.43012404520779 no 1949 0.427780714112047 2803 1551076
SGTC_2724 maprotiline 69.64 µM -0.182144636633251 0.430075647291504 no 1950 0.427734609814114 2748 4011 A tricyclic antidepressant.
SGTC_216 k038-0035 28.382 µM -0.182426749911828 0.429959448066245 no 1951 0.4276239173111 2719 4444231 YPR107C YTH1
SGTC_2669 eugenol 100 µM -0.182635189434787 0.429873598112625 no 1952 0.427542135764293 2747 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1884 5633444 25 µM -0.18301431386233 0.429717456696667 no 1953 0.427393393732953 2889 5724239
SGTC_1759 st043059 70 µM -0.183402292066069 0.429557680256929 no 1954 0.42724118878085 2747 669426
SGTC_3201 9113999 49.47 µM -0.185472263321671 0.428705424282214 no 1955 0.42642931674241 2940 16649224
SGTC_852 0418-0143 439 µM -0.18569229225124 0.42861485265484 no 1956 0.426343036544988 2822 5369229
SGTC_1711 st032263 62.8 µM -0.185796113493105 0.428572117494167 no 1957 0.426302326225762 2783 3958979
SGTC_2055 5235184 200 µM -0.186822251555966 0.428149781087828 no 1958 0.425899999926305 2890 2836034
SGTC_1781 st038725 66.3 µM -0.187798300377092 0.427748136691053 no 1959 0.425517384083064 2728 4270275 YIL048W NEO1
SGTC_2810 7959871 45.46 µM -0.19035325159428 0.426697128933995 no 1960 0.424516163828767 2853 2974535
SGTC_183 3914-0051 30.55 µM -0.190368243075105 0.426690963548726 no 1961 0.42451029048003 2862 1596232
SGTC_2623 humulene 100 µM -0.190512194334077 0.426631763172851 no 1962 0.424453894239984 2813 6187145 An anti-inflammatory.
SGTC_2010 4012422 159 µM -0.190744402522629 0.426536270360834 no 1963 0.424362924563615 2829 952393
SGTC_798 1287-0182 476 µM -0.192836690718051 0.425676036984536 no 1964 0.423543433854687 2894 1649755
SGTC_1717 st033143 58.0435 µM -0.194027827899545 0.425186464847716 no 1965 0.423077046214179 2890 674616
SGTC_2571 chrysanthemic acid 100 µM -0.195393259755557 0.4246253973782 no 1966 0.422542546428371 2809 2743 An insecticide.
SGTC_3296 9122258 64.045 µM -0.196028425151693 0.42436445452004 no 1967 0.422293958774545 2854 4730474
SGTC_1902 st060212 70.5 µM -0.197344120792383 0.423824037292767 no 1968 0.421779127378091 2758 688944
SGTC_2966 9084041 48.03 µM -0.200684979644699 0.422452437462127 no 1969 0.420472452643032 2710 17741380
SGTC_3043 9092303 49.47 µM -0.20177714251326 0.422004249672298 no 1970 0.420045475816494 2775 25236084
SGTC_442 cape 100 µM -0.201835452568645 0.421980323974466 no 1971 0.420022682368389 2869 5281787
SGTC_782 0083-0095 30.5 µM -0.202105396722415 0.421869564632143 no 1972 0.41991716447571 2726 3591729 An indicator and reagent.
SGTC_3067 9117431 49.47 µM -0.202847136351534 0.421565257256408 no 1973 0.419627257121706 2809 17150885
SGTC_3231 9132313 49.47 µM -0.205793601508239 0.420356899676552 no 1974 0.418476069742358 2830 4905967
SGTC_928 2764-0428 58.7 µM -0.206072974661541 0.420242366348733 no 1975 0.418366954394562 2893 662578
SGTC_3335 9143315 29.6265 µM -0.206212257912106 0.420185267556695 no 1976 0.41831255659464 2818 4899691
SGTC_295 k015-0027 31 µM -0.206508092722366 0.420063996450192 no 1977 0.418197021951289 2863 3887424
SGTC_138 0850-0259 40.9225 µM -0.207238327450218 0.419764684966273 no 1978 0.417911868001119 2843 6813004
SGTC_147 4466-0538 29.23 µM -0.209493525524083 0.418840609216047 no 1979 0.417031494570764 2980 6742687 YHR072W ERG7
SGTC_2959 9079155 11 µM -0.209543336922567 0.418820203845164 no 1980 0.417012054113448 2951 16189457
SGTC_182 3448-4371 550.524 µM -0.21164851029358 0.417958014353412 no 1981 0.416190630398025 2753 3491403
SGTC_1911 st060208 74.3 µM -0.211719274618174 0.417929039119596 no 1982 0.416163024997764 2889 688783
SGTC_1964 st076914 61 µM -0.211935057842385 0.417840687047609 no 1983 0.416078849792557 2760 24208661
SGTC_2226 7298446 200 µM -0.212749713239191 0.417507165204244 no 1984 0.415761094364136 2880 3283010
SGTC_1186 1319-0216 26 µM -0.213013610931337 0.417399137578404 no 1985 0.415658173162654 2952 4565136
SGTC_2511 berberine 10.47 µM -0.214735583310041 0.416694394391313 no 1986 0.414986739096752 2799 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2487 5918373 44.05 µM -0.215291063213366 0.416467112844572 no 1987 0.414770198396709 2784 2876279
SGTC_2670 beta-carotene 100 µM -0.215570368796268 0.416352842019504 no 1988 0.414661327501929 2885 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1658 st012944 20 µM -0.215816471074706 0.416252161346338 no 1989 0.41456540439949 2843 24207260
SGTC_890 0929-0006 47.2 µM -0.216048953936906 0.416157057436244 no 1990 0.414474794406232 2800 1378169
SGTC_1809 st050081 57.6 µM -0.216346590059463 0.416035307846717 no 1991 0.414358797629941 2945 5036894
SGTC_749 1000-0129 128 µM -0.21680277364386 0.415848719243478 no 1992 0.414181025157491 2950 708470
SGTC_2847 9005661 71.43 µM -0.217360087958611 0.415620791808076 no 1993 0.413963866405773 2804 2991449
SGTC_188 3229-0966 278.469 µM -0.217544484165182 0.415545384677106 no 1994 0.413892021805548 2836 5722370
SGTC_2109 5483026 200 µM -0.2183643062238 0.415210163683536 no 1995 0.413572636989408 2834 759335
SGTC_773 4358-1457 44.6 µM -0.218671501199652 0.415084569130959 no 1996 0.413452975232253 2937 1186886
SGTC_649 1123-0311 367 µM -0.21965127661658 0.414684052725358 no 1997 0.413071376754471 2892 693629 YIL048W NEO1
SGTC_2156 5649887 115 µM -0.220756660771625 0.414232295965687 no 1998 0.412640955354128 2902 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.221884062235585 0.413771657866617 no 1999 0.412202068897187 2812 65057 A dermal irritant. YDR527W RBA50
SGTC_997 3996-0078 137 µM -0.223790237583765 0.412993095444721 no 2000 0.411460263305366 2870 735687
SGTC_3013 9080133 71.4286 µM -0.224078849556436 0.412875243884369 no 2001 0.411347974827577 3005 17050193
SGTC_2828 7998861 71.43 µM -0.224146331854866 0.412847689353916 no 2002 0.411321720953607 2899 2988188
SGTC_558 k064-0027 21.3 µM -0.225250216215555 0.412397009760994 no 2003 0.410892313073374 2920 5088526
SGTC_3073 9114972 49.47 µM -0.225481195291186 0.412302723209368 no 2004 0.410802476358913 2921 41905075
SGTC_2079 5212404 121 µM -0.225836525373476 0.412157685979706 no 2005 0.41066428385515 2916 758462
SGTC_1465 k213-0056 144 µM -0.225949284991903 0.412111662710643 no 2006 0.410620432485804 2794 24048857 YMR208W ERG12
SGTC_1304 1165-0502 251 µM -0.226084351653188 0.412056536327921 no 2007 0.410567907545571 2842 767425
SGTC_91 0417-1751 58.384 µM -0.226317293132317 0.411961467195096 no 2008 0.410477324657837 2769 6795624
SGTC_2060 5238662 140 µM -0.226947701671296 0.411704207931583 no 2009 0.410232204534325 2909 790130
SGTC_500 h-89 112 µM -0.228555446423831 0.411048286033231 no 2010 0.409607228267402 3000 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2790 5423970 71.43 µM -0.230319473946798 0.410328890542093 no 2011 0.408921764659681 2985 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1859 st055998 20 µM -0.231457344453898 0.40986501065805 no 2012 0.408479759964197 2960 676301
SGTC_2630 antimycin a 100 µM -0.231797666901746 0.409726294618536 no 2013 0.408347584626671 2759 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2360 9040895 200 µM -0.232715949914203 0.409352057239395 no 2014 0.407990991490747 2885 4914414
SGTC_2988 9073640 71.4286 µM -0.232927195282411 0.409265977901614 no 2015 0.407908970199488 3009 9102229
SGTC_2404 5161160 200 µM -0.23309576176914 0.40919729270974 no 2016 0.407843522945011 2775 2831543
SGTC_2753 fluvastatin 17.09 µM -0.233227510846512 0.409143611318557 no 2017 0.407792372127427 2893 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1332 1480-0653 17.5 µM -0.235175997631264 0.408349896443503 no 2018 0.407036067358137 2934 5749438
SGTC_2190 6049624 200 µM -0.235828344559794 0.408084247148134 no 2019 0.406782936309573 2846 2265554
SGTC_728 3030-5151 22.5 µM -0.235983278146555 0.40802116115875 no 2020 0.406722822941787 2815 3125388
SGTC_1962 st076595 64.5 µM -0.23881775325461 0.406867439612363 no 2021 0.405623451696222 2820 279619
SGTC_2214 7179297 48.276 µM -0.238831031605822 0.40686203679414 no 2022 0.405618303337844 2813 769744
SGTC_3066 9117245 49.47 µM -0.239906791938632 0.406424380468945 no 2023 0.405201257699506 2876 17176980
SGTC_31 0508-1974 57.237 µM -0.241091704796817 0.40594245242067 no 2024 0.404742020899623 2933 6810525
SGTC_1627 st003713 25.6 µM -0.244554045652198 0.404535067374867 no 2025 0.403400874955745 2910 16195070 YER133W GLC7
SGTC_426 0988-0037 14.6 µM -0.24655217412149 0.403723421262325 no 2026 0.40262741074348 3000 5383008
SGTC_1920 st075728 45.7 µM -0.246662814947933 0.403678490685066 no 2027 0.402584593410571 3044 3400306
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.247392608275424 0.403382157853389 no 2028 0.402302197088463 2960 16725076
SGTC_3285 9112818 20.8695 µM -0.248157911240339 0.403071465903126 no 2029 0.402006114940652 2823 17017947 YPR165W RHO1
SGTC_3095 9117207 49.47 µM -0.248344459420002 0.402995741741394 no 2030 0.401933951274406 2972 17015229
SGTC_3325 9138760 55.175 µM -0.248350249171652 0.402993391607314 no 2031 0.401931711639956 2880 43844959
SGTC_3314 9135860 59.4275 µM -0.248657412664407 0.402868715052561 no 2032 0.401812897010652 2977 25252478
SGTC_96 0929-0093 37.281 µM -0.248900482519206 0.402770060873525 no 2033 0.401718881022696 2844 6991579
SGTC_3350 9150499 3.57 µM -0.25018225133283 0.402249934970218 no 2034 0.401223205143216 2830 4910996 YPR165W RHO1
SGTC_1177 0983-0204 23.6 µM -0.250370205617683 0.402173679974628 no 2035 0.401150534235337 2991 766818
SGTC_708 3448-5400 146 µM -0.252019847296708 0.401504563345101 no 2036 0.400512861454556 2907 3462195
SGTC_1657 st012939 43.4 µM -0.252046924273875 0.401493582965534 no 2037 0.400502396993355 3007 24207257
SGTC_2481 5478948 45.16 µM -0.252866926677732 0.401161088726059 no 2038 0.400185523866589 2994 77792
SGTC_3033 9090887 49.47 µM -0.253897756788336 0.400743209714255 no 2039 0.399787273922232 2858 19325384
SGTC_1948 st076329 66.6 µM -0.254374206433921 0.400550104391952 no 2040 0.399603238003087 2799 24208413
SGTC_2293 7624732 200 µM -0.254466382746406 0.400512748082542 no 2041 0.399567636074635 2810 894453
SGTC_1375 2910-0797 186 µM -0.254561242135528 0.400474305352325 no 2042 0.399530998713832 2924 742508
SGTC_3225 9130819 49.47 µM -0.254616251771049 0.400452012580836 no 2043 0.399509752852558 2987 4547121
SGTC_1518 st038567 90.8 µM -0.255689979009668 0.400016947364547 no 2044 0.399095116805342 2826 77966
SGTC_621 3584-0052 32.1 µM -0.259374294802311 0.398525040099038 no 2045 0.397673230502027 2952 2273927
SGTC_2780 5215298 71.43 µM -0.260211794198399 0.398186113463231 no 2046 0.397350203547862 3009 2834131
SGTC_3157 9099274 49.47 µM -0.261178500662574 0.397794993674004 no 2047 0.396977428426198 2982 17217662
SGTC_3126 9127922 49.47 µM -0.261650331568006 0.397604132869924 no 2048 0.396795518185968 3111 45595682
SGTC_1557 sumaresinolic acid 42.3 µM -0.26235810509815 0.397317876642994 no 2049 0.396522684469618 2868 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.262474972230292 0.397270615505104 no 2050 0.396477639202813 2857 23665772 A membrane-active detergent.
SGTC_2399 5884133 200 µM -0.264483119499474 0.3964587557368 no 2051 0.395703835269029 2891 722445
SGTC_2273 7815444 169.05 µM -0.265468385845637 0.396060593187581 no 2052 0.395324330424902 3061 2824616
SGTC_1824 st053723 68.6 µM -0.265880301259356 0.395894163416617 no 2053 0.395165698266384 2923 675225
SGTC_3009 9080819 71.4286 µM -0.266644404996136 0.395585486203639 no 2054 0.394871481385659 2936 17027216
SGTC_2867 9039098 71.43 µM -0.267060005399534 0.395417622380623 no 2055 0.39471148029365 2857 6463460
SGTC_653 0203-0016 55.2 µM -0.26732419266578 0.395310925435947 no 2056 0.394609780644955 2923 295302
SGTC_231 b-estradiol 524 µM -0.267648016386138 0.395180153904887 no 2057 0.394485133569275 2887 450 A steroid.
SGTC_3336 9143619 71.43 µM -0.268409693638206 0.394872608113189 no 2058 0.394191989373695 2956 45595730
SGTC_1112 tnp00069 1.16933 µM -0.268611416195979 0.394791168665813 no 2059 0.394114363112832 2980 145826
SGTC_2482 5981709 142.65 µM -0.271412023405104 0.393660983740606 no 2060 0.3930370778259 2931 877755
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.271992421498177 0.393426875788223 no 2061 0.392813923262582 2880 688803
SGTC_92 0063-0024 660.874 µM -0.272561814044071 0.393197244441101 no 2062 0.392595034400166 2832 3594437
SGTC_1715 st032160 10.2275 µM -0.27575894916523 0.391908558200263 no 2063 0.391366607694374 3006 5289825
SGTC_2905 7799065 20.05 µM -0.277022887513389 0.391399421882203 no 2064 0.390881265967766 3072 1296806
SGTC_892 0929-0076 29 µM -0.27706027411989 0.391384364735877 no 2065 0.390866912408078 2914 5751038
SGTC_1195 1502-0147 41.1 µM -0.27788723767004 0.391051353664026 no 2066 0.390549460537804 2903 817940
SGTC_2182 6325192 200 µM -0.277969902552398 0.391018069617325 no 2067 0.390517731439279 2898 736248
SGTC_618 k072-0232 33.2 µM -0.279323209668505 0.390473290026429 no 2068 0.389998398054825 2990 5872756 YGL099W LSG1
SGTC_1830 st055982 50.3 µM -0.279328263053047 0.390471256166967 no 2069 0.389996459179145 2996 455313 An antimicrobial agent.
SGTC_1755 st041960 45.185 µM -0.279529543274007 0.390390248406782 no 2070 0.38991923448482 3026 2257073
SGTC_112 phenothiazine 287.218 µM -0.279549407229075 0.390382254165777 no 2071 0.389911613564846 3036 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_519 k048-0011 62.8 µM -0.279921566496684 0.390232487384729 no 2072 0.389768840359944 3015 6836379
SGTC_371 0195-0006 7.36 µM -0.280453171498082 0.390018583660084 no 2073 0.389564924040668 2815 3928593
SGTC_735 3076-0345 636 µM -0.281481376936701 0.389604955656435 no 2074 0.389170604975876 3061 2888990
SGTC_1102 cgs 12066b 26.1 µM -0.282692649593778 0.389117843512611 no 2075 0.38870622564691 2941 6438352 A 5-HT1B full agonist.
SGTC_1527 coumarin 137 µM -0.282735072155251 0.389100786473314 no 2076 0.388689964506556 3092 323 A hepatotoxic, DNA x-linker.
SGTC_2220 6782180 200 µM -0.282814466577396 0.389068864557993 no 2077 0.388659532077133 2957 833803
SGTC_3093 9117344 49.47 µM -0.28314686572806 0.388935225801001 no 2078 0.388532128611993 3043 24824913
SGTC_1946 st076057 65.1 µM -0.285495608558276 0.387991305460434 no 2079 0.387632234169163 2881 953009
SGTC_306 1672-3436 11.6 µM -0.285615667783446 0.387943073393355 no 2080 0.387586250991846 3007 6797378
SGTC_715 0868-0130 184 µM -0.285873551507631 0.387839478161195 no 2081 0.387487485795878 3084 2876258
SGTC_74 000s-0487 160.283 µM -0.287040616285505 0.387370753032917 no 2082 0.3870406104341 2869 677548
SGTC_333 3486-0131 40.1 µM -0.288774969136833 0.386674492890198 no 2083 0.386376794084198 3078 6744690
SGTC_1056 3448-1962 115 µM -0.289319820625397 0.386455836103439 no 2084 0.386168322964565 2999 715507
SGTC_2533 agelasine 13.65 µM -0.291351280311772 0.385640900216174 no 2085 0.385391335812928 3118 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_754 3474-0146 171 µM -0.291526005696112 0.385570831280238 no 2086 0.385324528754946 2900 24762078
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.291928433205629 0.385409462713924 no 2087 0.385170671684818 2931 66535 A nucleotide analog.
SGTC_2204 7233102 200 µM -0.292111823333962 0.38533593206722 no 2088 0.385100563515848 2934 2172480
SGTC_171 k064-0041 9.68 µM -0.292778041036952 0.38506884542098 no 2089 0.384845906926474 2942 53325
SGTC_486 niguldipine 82 µM -0.294041915003532 0.384562308313014 no 2090 0.384362937400656 2918 1236 A calcium channel blocker.
SGTC_2495 cafestol 54.53 µM -0.294657031842651 0.384315852183242 no 2091 0.384127945069974 3116 16667697 An anti-infammatory.
SGTC_3115 9123671 49.47 µM -0.29475695599399 0.384275820430152 no 2092 0.384089775188106 2960 3286988
SGTC_1735 st034310 56.75 µM -0.295603229674437 0.383936834620771 no 2093 0.38376655344379 3109 871153
SGTC_3297 9117502 71.43 µM -0.296864603132144 0.383431740107954 no 2094 0.383284940585965 3003 7453720
SGTC_3333 9141820 12.094 µM -0.296907223760779 0.383414676891348 no 2095 0.383268670483479 2953 1939433
SGTC_592 k241-0073 46.5 µM -0.297682876476604 0.383104182990736 no 2096 0.382972606923957 3055 4230158
SGTC_2621 lithochol-11-enic acid 100 µM -0.2982153885839 0.382891061769262 no 2097 0.382769388730328 3018 6708711
SGTC_120 rhodamine 6G 52.259 µM -0.300484351283234 0.381983378865509 no 2098 0.381903865560609 2906 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2269 7935389 174.42 µM -0.301550775348574 0.381556986920322 no 2099 0.381497268784404 2915 97605
SGTC_875 0709-0210 25.7 µM -0.301966662182301 0.381390740397114 no 2100 0.381338738524865 3067 6251364
SGTC_2021 4019055 173 µM -0.302477350876728 0.381186627731547 no 2101 0.381144098352836 3088 44827708 YER133W GLC7
SGTC_2523 spermine 47.74 µM -0.30355840391124 0.380754660256544 no 2102 0.38073217290439 3056 1103 A DNA binding polyamine.
SGTC_1237 0330-0133 46.1 µM -0.304201530917733 0.380497749849372 no 2103 0.380487179286605 2918 X1237 YHR072W ERG7
SGTC_2904 7225135 42.03 µM -0.306371706863667 0.379631217648714 no 2104 0.379660823964276 3059 4446116
SGTC_842 0271-0008 11.1 µM -0.307762073676069 0.379076373625193 no 2105 0.379131691269378 3069 1221709
SGTC_3168 9103419 49.47 µM -0.309097276090721 0.378543778062451 no 2106 0.378623765584022 3022 16649256
SGTC_2135 5326629 150.42 µM -0.310228145609854 0.378092868668078 no 2107 0.37819373427267 2996 5020077
SGTC_2755 lomerizine 42.69 µM -0.311616615062019 0.377539474034666 no 2108 0.377665952791384 2990 3949 A calcium channel blocker.
SGTC_1716 st033144 30.6155 µM -0.312573838223298 0.377158105138727 no 2109 0.377302228452586 3127 674617
SGTC_2591 skatole 100 µM -0.312690315734565 0.377111707304342 no 2110 0.377257976908009 3073 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3294 9122953 26.2835 µM -0.313124635156233 0.376938715472093 no 2111 0.377092986692264 2941 16459826
SGTC_817 1391-0715 46 µM -0.313822534495039 0.376660790046491 no 2112 0.376827914163253 3000 1353946
SGTC_2446 5162541 200 µM -0.314504754188496 0.376389170521568 no 2113 0.376568853102752 2932 1549321
SGTC_617 3770-0098 35 µM -0.314669740243672 0.376323492019043 no 2114 0.376506210860057 2982 5962639
SGTC_886 0866-0150 153 µM -0.316106591438049 0.375751654445703 no 2115 0.375960801915923 3133 271463
SGTC_2464 5717415 7.67 µM -0.316720379094232 0.375507462511838 no 2116 0.375727892003384 2981 5285744
SGTC_2691 st077356 60.2 µM -0.317664830907246 0.375131815149712 no 2117 0.375369595621532 3134 2839272
SGTC_642 0335-0876 158 µM -0.317665734914426 0.37513145564551 no 2118 0.37536925272006 2967 6812350
SGTC_2235 salicylic acid 500 µM -0.318393035281702 0.374842259114668 no 2119 0.37509341032941 2982 338 A COX inhibitor and kinase inhibitor.
SGTC_872 0588-0139 234 µM -0.318795427540099 0.374682286057685 no 2120 0.37494082290622 2959 2047100
SGTC_1748 st037455 53.6035 µM -0.319706706561982 0.374320082274371 no 2121 0.374595337658114 3150 580690
SGTC_3353 9151644 39.2805 µM -0.320140606554756 0.374147660086421 no 2122 0.37443087229937 3088 4909158
SGTC_2180 6301957 200 µM -0.320160744762773 0.37413965822234 no 2123 0.374423239671901 3102 845462
SGTC_2751 anetholtrithion 17.25 µM -0.320240093811066 0.374108129614147 no 2124 0.374393165889807 3100 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2909 7941780 10.49 µM -0.320641757912981 0.373948545033693 no 2125 0.374240944429036 3129 1243215
SGTC_1849 st056239 19.2 µM -0.321313765277737 0.373681599082989 no 2126 0.373986312932559 2965 5393181
SGTC_1743 st037606 46.3785 µM -0.321844517546257 0.373470807649861 no 2127 0.373785243505047 2986 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3105 9121040 49.47 µM -0.323760738072726 0.372710084678012 no 2128 0.373059591469019 3002 41448907
SGTC_1758 st042942 75.2445 µM -0.325318470469267 0.372092043868036 no 2129 0.372470026543936 3019 669317
SGTC_1447 4239-0816 81.9 µM -0.325429639618097 0.372047949333625 no 2130 0.372427963050163 2985 1341554
SGTC_1135 dihydrocapsaicin 536.708 nM -0.325478460193563 0.372028585493707 no 2131 0.372409491104143 2924 107982 A Capsaicinoid.
SGTC_1881 5652484 16 µM -0.326043334666094 0.371804561317087 no 2132 0.372195784320045 3123 2255129
SGTC_1185 1319-0113 81.3 µM -0.32645603122598 0.371640916975162 no 2133 0.372039675296234 3080 4672763
SGTC_2944 9067346 25.62 µM -0.328909858904894 0.370668393757344 no 2134 0.371111911111776 3152 6473075
SGTC_2163 5671233 125 µM -0.329296286365339 0.370515316429251 no 2135 0.370965875397189 3203 701023
SGTC_1148 3909-7663 27.7 µM -0.33153044620034 0.369630690740839 no 2136 0.370121923660589 3116 4084526
SGTC_1295 1013-0063 9.78 µM -0.332880535336306 0.369096450802405 no 2137 0.369612231441748 3110 6826038
SGTC_3163 9099914 49.47 µM -0.333255865743424 0.368947974731314 no 2138 0.36947057552832 3075 16268368
SGTC_2280 7785178 200 µM -0.334226720768016 0.368564007238151 no 2139 0.369104240988783 2994 2954328
SGTC_2871 9038510 12.99 µM -0.335549601210411 0.368041026980183 no 2140 0.368605267406346 3202 4945164
SGTC_1687 st020778 55.3625 µM -0.335949014797454 0.367883173022642 no 2141 0.36845465719748 3025 4259299
SGTC_518 1021-0119 62.6 µM -0.336108029211352 0.367820334461512 no 2142 0.368394701930513 3030 1097762
SGTC_1663 st014140 55.4 µM -0.336668083884338 0.367599042896886 no 2143 0.368183562778947 3031 4207120
SGTC_224 benfluorex 43.875 µM -0.336784127828519 0.36755319653593 no 2144 0.368139819491133 3103 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2358 9037157 4 µM -0.337399542489275 0.367310091562145 no 2145 0.367907864746621 3086 2388925
SGTC_1984 st072354 53.1 µM -0.33754148796447 0.367254026910641 no 2146 0.367854371185269 2959 5762938
SGTC_43 0570-0105 72.5 µM -0.339563367342377 0.366455746624004 no 2147 0.367092684584651 2993 1114046 YDL195W SEC31
SGTC_3158 9100007 49.47 µM -0.339769541728327 0.366374377048355 no 2148 0.367015043466535 3004 19297233
SGTC_80 0159-0065 512.242 µM -0.341525099941982 0.365681765375608 no 2149 0.366354156242935 3020 1548079
SGTC_759 3486-0358 89.3 µM -0.341623461842228 0.365642972069811 no 2150 0.366317139196974 3186 875103
SGTC_251 melphalan 456.522 µM -0.34185315927093 0.365552386221372 no 2151 0.366230700812329 3069 460612 A DNA alkylator.
SGTC_1412 3909-8563 178 µM -0.342882714161254 0.365146452518134 no 2152 0.365843348220488 3114 23767530
SGTC_2914 7968218 45.32 µM -0.343752476402939 0.364803639674458 no 2153 0.365516221427379 3100 2977111
SGTC_2377 9073351 62.6 µM -0.344160746331256 0.36464275918329 no 2154 0.365362700494223 2990 7337946 YHR072W ERG7
SGTC_76 0433-0009 400.328 µM -0.344535477448454 0.364495115780025 no 2155 0.365221810077966 3105 2841569
SGTC_214 4373-3496 70 µM -0.346188819531924 0.363843942145145 no 2156 0.364600408284493 3064 3779166
SGTC_1684 st024538 14.6195 µM -0.348297835237802 0.363013870727651 no 2157 0.36380825971091 3022 6732859
SGTC_1764 st044502 93.5 µM -0.348428456694525 0.362962481533653 no 2158 0.36375921724754 3145 8407
SGTC_126 0417-1624 672.48 µM -0.348879478302705 0.362785059239846 no 2159 0.363589896147086 3141 41912 YDL195W SEC31
SGTC_1501 4491-0275 38.4 µM -0.352031768418806 0.361545839691769 no 2160 0.362407218877142 3135 5104718
SGTC_2855 9016525 58.44 µM -0.352960848764753 0.361180878446393 no 2161 0.36205889600851 2983 43811474
SGTC_530 4358-1714 28 µM -0.353253660554246 0.361065882312902 no 2162 0.361949141169416 3095 1564641
SGTC_3122 9126309 49.47 µM -0.354068484473299 0.360745942185507 no 2163 0.361643779948979 3109 17591206
SGTC_2076 5212012 200 µM -0.354643486966582 0.360520226424166 no 2164 0.361428346562698 3027 604802
SGTC_1845 st056753 3.01 µM -0.355092591977071 0.360343965192051 no 2165 0.361260113123577 2972 5375839
SGTC_1399 3562-5772 25 µM -0.355265878743491 0.360275962885949 no 2166 0.361195207572512 2970 23847490
SGTC_1067 clotrimazole 1.36 µM -0.356514447681792 0.359786122223485 no 2167 0.360727667140289 3052 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_420 mitomycin C 81.9 mM -0.357005729053233 0.359593444961343 no 2168 0.360543758410778 3026 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_859 0439-0102 54.6 µM -0.35753793002297 0.359384759576429 no 2169 0.360344568029529 3165 610143
SGTC_577 r071-0003 38.6 µM -0.35756217763661 0.359375252657933 no 2170 0.360335493616917 3030 4568517 YMR134W ERG29
SGTC_1969 st069479 40.1 µM -0.357898153885802 0.359243533242012 no 2171 0.360209766163316 3197 3895485
SGTC_3027 9089541 49.47 µM -0.358174434765805 0.359135229915561 no 2172 0.360106388956644 3132 9943819
SGTC_690 glyoxal 20.3 µM -0.358944484728993 0.35883342669225 no 2173 0.35981831005629 3088 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1036 k216-0215 33.5 µM -0.360356679805927 0.358280178654773 no 2174 0.359290208984747 3018 622330
SGTC_2848 9016370 25.97 µM -0.363366173719484 0.357102158911533 no 2175 0.358165683424661 3170 7894410
SGTC_1283 0922-0125 16.4 µM -0.363482952057373 0.357056475199369 no 2176 0.358122072819878 3135 3360884
SGTC_491 tetrandrine 80.3 µM -0.367241784778912 0.355587116879314 no 2177 0.356719336856135 3132 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1260 0700-1617 7.75 µM -0.367242388860145 0.355586880910739 no 2178 0.356719111577779 3156 2853078
SGTC_3222 9128301 49.47 µM -0.36758363214945 0.355453591970637 no 2179 0.356591860645251 3041 4911358
SGTC_1799 st045822 46.1415 µM -0.36881486987588 0.354972820055966 no 2180 0.356132860148629 3192 3674992
SGTC_581 0958-0271 211 µM -0.369303950076278 0.354781908744997 no 2181 0.35595059080208 3052 4591145
SGTC_2690 usnic acid 100 µM -0.370208183445022 0.354429039425225 no 2182 0.355613689794457 3299 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_771 0250-0039 27.3 µM -0.370743462645323 0.354220210147111 no 2183 0.355414307557867 3067 3005115
SGTC_1250 0485-0349 40.2 µM -0.371778643899891 0.35381647772121 no 2184 0.355028832743297 3070 6842794 YDL195W SEC31
SGTC_2461 5755302 26.15 µM -0.372286710739976 0.353618385986723 no 2185 0.354839695990171 3197 2788904
SGTC_3005 9076496 71.4286 µM -0.372295114790308 0.353615109638908 no 2186 0.354836567736311 3163 21368410
SGTC_1318 1280-3875 124 µM -0.372760042439879 0.353433872902421 no 2187 0.354663522185074 3117 373245
SGTC_2484 5809818 12.04 µM -0.373848491733816 0.353009706792478 no 2188 0.35425851991081 3086 2870548
SGTC_415 dibenzyl ketone 100 µM -0.374935767000065 0.352586180482434 no 2189 0.35385411898315 3120 7593
SGTC_2744 captopril 92.04 µM -0.375648247161174 0.352308747135849 no 2190 0.353589208632046 3142 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1583 clindamycin 39.6 µM -0.375972007190344 0.352182703856087 no 2191 0.353468853425155 3073 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2679 rapamycin 1 nM -0.376433637552573 0.352003014246749 no 2192 0.353297271359947 3146 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2584 androsterone 48.74 µM -0.377516714573882 0.351581556311797 no 2193 0.352894822655597 3183 2754130 A steroid.
SGTC_2232 chlorophetanol 41.5365 µM -0.378096496496007 0.351356020587344 no 2194 0.35267945543462 3166 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1217 1183-1422 255 µM -0.378220568797509 0.351307763137663 no 2195 0.352633373361698 3211 2849664
SGTC_445 e6 berbamine 66 µM -0.379229433512005 0.350915458095235 no 2196 0.352258748165338 3159 6610268 A calcium/calmodulin antagonist.
SGTC_369 0957-0393 4.5 µM -0.381296098788617 0.350112315362456 no 2197 0.351491774060894 3114 6997992
SGTC_1397 3532-0190 20.1 µM -0.381646308757361 0.349976283850941 no 2198 0.351361865060538 3003 5322280
SGTC_2862 9027634 71.43 µM -0.38190209976814 0.349876939512344 no 2199 0.35126699136941 3040 5012562
SGTC_2551 apiole 73.87 µM -0.381959201290196 0.349854763775606 no 2200 0.351245813500267 3063 10659 A possible DNA adduct former.
SGTC_809 3998-0021 90 µM -0.38274052464284 0.349551383394395 no 2201 0.350956081944577 3217 715485
SGTC_1191 1487-1166 10.6 µM -0.383230326500074 0.34936124699539 no 2202 0.350774497014876 3189 3955771
SGTC_2616 abietic acid 100 µM -0.383885431953654 0.349107000407357 no 2203 0.350531682133327 3241 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2680 butyl paraben 22.24 µM -0.384584845504051 0.34883563257435 no 2204 0.35027251184559 3135 7184 An antifungal and steroid mimetic.
SGTC_2014 4013930 200 µM -0.384741628550417 0.348774812391291 no 2205 0.350214424865589 3180 64556
SGTC_2150 5556613 200 µM -0.38537482957191 0.3485292169543 no 2206 0.349979864148957 3104 743190
SGTC_2344 7990960 76.95 µM -0.385595314559319 0.348443713814474 no 2207 0.349898201910051 3095 140813
SGTC_1834 st055981 52.8 µM -0.386270507459472 0.348181924792723 no 2208 0.34964817019431 3241 471719 YDL150W RPC53
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.388243074911736 0.34741752618622 no 2209 0.348918079572218 3178 688801
SGTC_1263 0774-1208 64.8 µM -0.388699998631907 0.347240549938096 no 2210 0.34874904168836 3262 906585
SGTC_862 0452-0056 10.2 µM -0.389182861134887 0.347053563242961 no 2211 0.348570440435945 3165 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2228 7354201 200 µM -0.389582563502326 0.346898808163207 no 2212 0.348422623852883 3108 753451
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.390302963512758 0.346619951222131 no 2213 0.348156266085078 3085 364106
SGTC_3208 9114115 49.47 µM -0.392429256029254 0.345797377637709 no 2214 0.347370536470969 3162 650895
SGTC_1024 4507-0395 26 µM -0.393022922988894 0.345567842459713 no 2215 0.347151275415984 3252 4201836
SGTC_2817 7995342 71.43 µM -0.393191553758664 0.345502653469143 no 2216 0.347089003761013 3026 18879975
SGTC_1251 0490-5699 265 µM -0.393781179653186 0.345274752943647 no 2217 0.346871300281132 3272 3883818
SGTC_110 0850-0284 111.64 µM -0.394559784963996 0.344973894581217 no 2218 0.34658389868796 2997 3906265
SGTC_1868 st057644 42.7 µM -0.395158133949045 0.344742755052484 no 2219 0.346363093938139 3060 688665
SGTC_587 k089-0003 57 µM -0.396451214165391 0.34424344196714 no 2220 0.345886095529917 3161 9659696
SGTC_1976 st070609 63.5 µM -0.396823723578803 0.344099650604811 no 2221 0.345748727574773 3058 682556
SGTC_341 1486-1430 230 µM -0.397531015259241 0.343826692874814 no 2222 0.345487959956469 3043 2054753 YPL210C SRP72
SGTC_3080 9117754 49.47 µM -0.399565277306694 0.343042085321778 no 2223 0.344738367692116 3311 9550191
SGTC_736 0958-0254 92.6 µM -0.400099568648722 0.342836123072315 no 2224 0.344541590959692 3215 6812352
SGTC_318 1488-0629 67.2 µM -0.400643778934924 0.342626385208921 no 2225 0.344341204370749 3192 3662576
SGTC_2007 4011539 71.82 µM -0.400999385071203 0.342489361314072 no 2226 0.344210288324204 3086 45595301
SGTC_552 k242-0005 476 µM -0.401219727165246 0.34240446842058 no 2227 0.344129178966547 3234 4088318
SGTC_1887 st057648 70.8 µM -0.401263181298715 0.342387727452083 no 2228 0.344113184063799 3209 688672
SGTC_312 4092-0653 6.84 µM -0.402522420393046 0.341902732583732 no 2229 0.343649795735839 3190 1148278
SGTC_1679 SEC14.276 6.7 µM -0.402786422012104 0.341801085625563 no 2230 0.343552675339441 3211 1005053 YMR079W SEC14
SGTC_1581 himbacine 57.9 µM -0.402885980272508 0.341762756283785 no 2231 0.343516052723609 3106 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1307 1187-1599 12.2 µM -0.40619658588733 0.340489123816408 no 2232 0.342299081220727 3090 1538471
SGTC_3036 9090181 49.47 µM -0.407150221584034 0.340122584356173 no 2233 0.341948829696949 3113 25236586
SGTC_1771 st048882 4.1505 µM -0.409294851529453 0.339298826505756 no 2234 0.341161646669952 3114 4580403
SGTC_2091 4-phenylthiadiazole 200 µM -0.411085686872958 0.33861154979551 no 2235 0.340504852429166 3104 270010
SGTC_1294 1000-1494 117 µM -0.411291279687371 0.338532682869545 no 2236 0.340429481543812 3153 712797 YDL207W GLE1
SGTC_162 k030-0015 37.8 µM -0.412481689058023 0.338076172311104 no 2237 0.339993199590755 3188 1809920 YMR134W ERG29
SGTC_472 calcifediol 10 µM -0.412736957499913 0.337978310283196 no 2238 0.339899672237429 3172 5283731 A vitamin D metabolite.
SGTC_2217 6934799 96.0675 µM -0.413379067343167 0.337732193645394 no 2239 0.339664454323874 3215 675606
SGTC_1749 st037932 54.2 µM -0.415133450795651 0.337060103536686 no 2240 0.339022106459657 3237 594497
SGTC_3259 9138485 49.47 µM -0.41532280823577 0.336987593275015 no 2241 0.33895280328522 3427 17646153
SGTC_3141 9094609 49.47 µM -0.418447295300556 0.335792016038764 no 2242 0.337810056656619 3072 25236309 YDL196W YDL196W
SGTC_562 3772-2733 112 µM -0.420318881974199 0.335076652177951 no 2243 0.337126258967547 3250 2876874 YIL048W NEO1
SGTC_1469 k284-2957 126 µM -0.420431509946242 0.33503362219884 no 2244 0.337085126658615 3180 23884841
SGTC_2717 st081029 62.2815 µM -0.423417328487168 0.333893669037354 no 2245 0.335995402083409 3253 5292846
SGTC_2900 5328528 85.29 µM -0.423696715547651 0.333787080266932 no 2246 0.335893505407089 3167 795359
SGTC_1253 0550-0034 176 µM -0.42412450705898 0.333623899804376 no 2247 0.335737506763668 3243 5969915
SGTC_1479 0549-0158 134 µM -0.424506035846326 0.333478392738996 no 2248 0.335598402181042 3180 5440202
SGTC_528 3492-0019 172 µM -0.424918342091906 0.33332117595993 no 2249 0.335448101530205 3232 2869262
SGTC_62 0180-0423 3.232 µM -0.42735783055827 0.332391572808303 no 2250 0.33455935855147 3179 30102 YGL099W LSG1
SGTC_2920 7982904 15.77 µM -0.430007660430064 0.331382983016338 no 2251 0.333595034397448 3220 6456808
SGTC_2207 7258803 200 µM -0.430717000878723 0.331113197753089 no 2252 0.333337077843642 3237 3666799
SGTC_1288 0973-0013 65.5 µM -0.431691140057384 0.330742843773204 no 2253 0.332982953839228 3282 4315430
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.431847269052457 0.330683501121671 no 2254 0.332926210873314 3258 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_929 2805-0021 398 µM -0.43242828379014 0.330462702181687 no 2255 0.332715082564133 3237 3098024
SGTC_1173 0443-0020 122 µM -0.433384929736916 0.330099283335192 no 2256 0.332367573505682 3153 5331295
SGTC_2641 levomentholum 100 µM -0.435532795582632 0.329283917906894 no 2257 0.331587869741977 3230 16666
SGTC_2415 st077333 57.7 µM -0.436689415991793 0.328845181435422 no 2258 0.331168303019875 3386 2766255
SGTC_1793 st048256 72.231 µM -0.437330226245909 0.328602206736372 no 2259 0.330935938798871 3211 672022
SGTC_1072 oxiconazole 14.9 nM -0.438495714953718 0.328160476557858 no 2260 0.330513487865568 3253 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_641 4092-0595 30 µM -0.439551670268221 0.327760467834359 no 2261 0.330130925504475 3258 786260
SGTC_320 4092-0846 5.34 µM -0.440506343930194 0.327398995855261 no 2262 0.329785209293333 3244 1359356
SGTC_2372 9071633 200 µM -0.440541458757544 0.327385703267617 no 2263 0.329772495922186 3306 21321366
SGTC_1614 st002383 48.6 µM -0.44112145267179 0.327166180394816 no 2264 0.32956253679483 3253 1947235
SGTC_2777 climbazole 1.536 µM -0.441409978441878 0.327056998049746 no 2265 0.32945810980613 3253 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2027 5150920 200 µM -0.441880751181381 0.326878882581026 no 2266 0.329287750185796 3218 786715
SGTC_974 1326-0144 138 µM -0.442785631755791 0.326536634481048 no 2267 0.3289603984995 3206 5411856
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.443055316617127 0.326434661248993 no 2268 0.328862862036438 3294 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1896 st058441 89 µM -0.44343585126168 0.326290795563713 no 2269 0.328725254545863 3189 688759
SGTC_2300 7976697 71.57 µM -0.444813391679744 0.325770216117793 no 2270 0.328227307894341 3127 2236109
SGTC_2666 tannic acid 100 µM -0.445561710742919 0.325487564836629 no 2271 0.327956936942362 3293 16134267 A thiamine antagonist.
SGTC_3002 9075603 71.4286 µM -0.448453117700481 0.324396381233391 no 2272 0.326913106991314 3260 20105405
SGTC_800 3448-7362 155 µM -0.449110741619918 0.32414841145651 no 2273 0.326675886023803 3293 15991913
SGTC_2151 5563267 85.4165 µM -0.4493733449638 0.32404941358637 no 2274 0.326581178167817 3219 5310824
SGTC_1615 st002656 86.5 µM -0.452038848757423 0.323045260179691 no 2275 0.325620497946412 3290 1584458
SGTC_1696 st025591 34.7925 µM -0.452215658903848 0.322978697426378 no 2276 0.325556814256989 3191 2787147
SGTC_1061 3448-9325 110 µM -0.452292633936755 0.322949720825959 no 2277 0.325529090888607 3286 723482
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.452569808431067 0.322845389733502 no 2278 0.325429271572724 3112 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2943 9068529 45.32 µM -0.456575823375722 0.321339048212449 no 2279 0.323987979935824 3274 3270634
SGTC_804 1595-0054 20.9 µM -0.457259538492536 0.321082250124264 no 2280 0.323742254228544 3204 761523 Stimulates phospholipase C.
SGTC_2417 cerulenin 830 nM -0.458344903567715 0.320674771146607 no 2281 0.323352334195194 3351 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1316 1272-0050 65.9 µM -0.458774023998726 0.320513725869527 no 2282 0.323198225113506 3268 7340392
SGTC_865 0488-0499 301 µM -0.460249064566332 0.319960413411506 no 2283 0.322668728516892 3359 9634651
SGTC_422 cantharidin 155 µM -0.460294880296833 0.319943233565909 no 2284 0.322652287753636 3156 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1597 7-benzyloxygramine 47.5 µM -0.462252832444367 0.319209407800583 no 2285 0.321950010033097 3275 260807
SGTC_419 nsc-638432 893 µM -0.462598538376679 0.319079913248189 no 2286 0.321826078258084 3253 368090
SGTC_1454 4239-0054 42.6 µM -0.462688441892315 0.319046240799244 no 2287 0.321793852082978 3385 1340767
SGTC_2665 lovastatin 100 µM -0.463288107258312 0.318821680431117 no 2288 0.321578934598761 3268 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1396 3511-0007 98.6 µM -0.464219682546316 0.318472959639228 no 2289 0.321245180459422 3288 X1396
SGTC_1850 st056238 17 µM -0.465244595072961 0.318089485215215 no 2290 0.320878153244601 3298 5393177
SGTC_2512 diallyl trisulfide 49.23 µM -0.465251865637763 0.318086765605096 no 2291 0.320875550237154 3304 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_118 0083-0097 135.343 µM -0.465287356728863 0.318073490033063 no 2292 0.320862843843918 3334 5207356
SGTC_1065 prochlorperazine maleate 2.48 µM -0.466649390747962 0.317564192986196 no 2293 0.320375371963622 3335 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_557 1315-0110 16.2 µM -0.467272022398686 0.317331491015739 no 2294 0.320152635254683 3200 6833801
SGTC_2311 7694451 200 µM -0.468071920222117 0.317032643640941 no 2295 0.319866579451334 3228 2163142
SGTC_755 1995-0008 37.3 µM -0.469473950414308 0.31650912334034 no 2296 0.319365450240898 3327 689533
SGTC_2865 9030313 51.95 µM -0.470827324989192 0.316004119593584 no 2297 0.318882024830055 3167 42562754
SGTC_1341 1486-1360 280 µM -0.471632185914266 0.315703953132158 no 2298 0.318594674479992 3200 3976547
SGTC_1668 st014914 51.6 µM -0.471994223774619 0.315568973612994 no 2299 0.318465455768664 3323 2839556
SGTC_968 1309-0633 340 µM -0.47228251574939 0.315461506558749 no 2300 0.318362574261318 3328 3761976
SGTC_1003 4049-0218 100 µM -0.472790471509367 0.315272193069048 no 2301 0.318181336376944 3376 295161
SGTC_1768 st044301 37.178 µM -0.47327008071506 0.315093488758544 no 2302 0.318010252446776 3255 3931349
SGTC_2783 7738165 71.43 µM -0.47332806493929 0.315071886535384 no 2303 0.317989571218588 3257 17201110
SGTC_758 0868-0029 16 µM -0.474974238982086 0.314458862801611 no 2304 0.317402667470214 3335 762687
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.47594981347923 0.314095806804816 no 2305 0.317055066254019 3400 688751
SGTC_1286 0929-0070 131 µM -0.48325672818342 0.311382305971029 no 2306 0.314456730293984 3356 1420408
SGTC_2342 7990637 118.86 µM -0.483880278844904 0.311151214835808 no 2307 0.314235418570587 3357 2033102 YER133W GLC7
SGTC_159 3970-0959 50 µM -0.484603628214147 0.3108832310226 no 2308 0.313978769763134 3416 6615653
SGTC_2357 9067248 200 µM -0.485681248817929 0.310484184091141 no 2309 0.313596590191122 3338 9150235
SGTC_2254 7938975 95.19 µM -0.487052811612356 0.309976611732788 no 2310 0.313110452909026 3435 2969277
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.487087006040456 0.309963962068223 no 2311 0.313098337166666 3320 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2712 st079126 47.7 µM -0.487451254487492 0.309829228327702 no 2312 0.312969289474657 3241 3152970
SGTC_2746 daunorubicin 9.88 µM -0.487953312077549 0.309643561516901 no 2313 0.312791455651837 3263 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2450 5739737 12.93 µM -0.488657661354823 0.309383166718523 no 2314 0.312542041520621 3338 2262825
SGTC_479 n-linoleoylglycine 10 µM -0.48892415365753 0.309284670642355 no 2315 0.312447697438314 3277 6433346 An anti-infammatory.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.48981934922305 0.308953904973191 no 2316 0.312130868725659 3284 688761
SGTC_403 arphamenine a 50 µM -0.490679374252241 0.308636280297286 no 2317 0.311826618425757 3296 5487158 An arginine aminopeptidase inhibitor.
SGTC_1980 st071811 45.7 µM -0.492231078557067 0.308063566619091 no 2318 0.311277998209602 3408 4974850
SGTC_2804 7954240 19.48 µM -0.49392732545575 0.307438038501044 no 2319 0.310678752802339 3367 828705
SGTC_873 0591-4978 488 µM -0.494729622917208 0.307142368604887 no 2320 0.310395494116317 3457 3305145
SGTC_525 k781-2675 26.7 µM -0.497918003910963 0.30596859798017 no 2321 0.309270918486922 3386 3651118 YDL195W SEC31
SGTC_379 3970-0972 5.9 µM -0.498132757853863 0.305889609855624 no 2322 0.309195236532709 3338 2898042 YBL034C STU1
SGTC_880 0833-0487 87.2 µM -0.50044390814873 0.305040123252902 no 2323 0.308381271406409 3307 76075
SGTC_1775 st081588 35.1725 µM -0.500585164746689 0.304988236952232 no 2324 0.308331552655406 3396 1426443 YGL099W LSG1
SGTC_197 4544-0043 41.561 µM -0.500768417199859 0.304920930597757 no 2325 0.30826705766395 3340 896523
SGTC_857 0438-0306 1.35 µM -0.502188237521269 0.304399671993307 no 2326 0.307767558084629 3398 4686136
SGTC_1649 st011737 51.3 µM -0.503311022997401 0.303987744876011 no 2327 0.307372808839371 3328 1761035
SGTC_2044 5102272 200 µM -0.503542424019054 0.303902879452713 no 2328 0.30729148050582 3358 592666
SGTC_761 k216-0224 480 µM -0.503764199253387 0.303821554166896 no 2329 0.307213544149646 3444 1340404
SGTC_57 miconazole 162.5 nM -0.503810562114643 0.303804554068453 no 2330 0.307197252391593 3328 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3108 9121785 49.47 µM -0.505995056031732 0.303004036535121 no 2331 0.306430060189693 3372 17140271
SGTC_1806 st050005 60.3 µM -0.508855521532414 0.30195723594874 no 2332 0.305426749345048 3310 5194765
SGTC_916 4466-0038 42 nM -0.508935223960259 0.301928091752639 no 2333 0.305398814515979 3475 5722064 YGL116W CDC20
SGTC_1900 st060200 72.8 µM -0.508972867557656 0.301914327336768 no 2334 0.305385621240844 3277 688945
SGTC_226 1,3-diallylurea 8.28947 mM -0.509518366613895 0.301714896760283 no 2335 0.305194463876954 3334 74537 YKL182W FAS1
SGTC_713 1488-1073 324 µM -0.509875248581087 0.301584455310462 no 2336 0.305069431696472 3371 3312542
SGTC_2234 tolnaftate 200 µM -0.51054798773307 0.301338636103619 no 2337 0.304833802075447 3327 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2942 9052777 62.25 µM -0.511070001446836 0.301147954227171 no 2338 0.30465102040132 3367 6469503
SGTC_2629 bisabolol 100 µM -0.512038383503545 0.300794366370785 no 2339 0.304312073219935 3418 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1810 st050138 53 µM -0.512987559100249 0.300447973299309 no 2340 0.303980011624163 3384 3444541
SGTC_2941 9056145 11.23 µM -0.513419709348796 0.300290323684267 no 2341 0.303828880806891 3368 2119517
SGTC_36 0335-0881 14.2 µM -0.51345889912936 0.300276028992339 no 2342 0.303815177084269 3335 23828853
SGTC_1609 st001574 46.4 µM -0.514220483433106 0.299998297943089 no 2343 0.303548924157765 3298 3960012
SGTC_2428 5615643 7.78 µM -0.516843197881248 0.299042749143284 no 2344 0.302632811059908 3374 2253075
SGTC_1604 st002052 72.4 µM -0.517263322162565 0.298889811325481 no 2345 0.302486177013894 3442 6254834 YHR062C RPP1
SGTC_2541 muurolladie-3-one 83.07 µM -0.520972393455002 0.297541142829299 no 2346 0.301193001421744 3454 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_815 1582-0027 36.9 µM -0.522098132559691 0.2971323591139 no 2347 0.300801003321312 3400 3128206
SGTC_1640 st009078 66.4 µM -0.522577452681134 0.296958384095345 no 2348 0.30063416724336 3401 690618
SGTC_832 4083-0019 164 µM -0.522736926556076 0.296900511462642 no 2349 0.300578668725652 3424 1990758
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.523648442110377 0.296569824059594 no 2350 0.300261540938191 3398 4213774
SGTC_2330 7979373 200 µM -0.523803932770264 0.296513430680274 no 2351 0.300207458875573 3310 1863007
SGTC_3307 9126885 69.2785 µM -0.524688402466106 0.296192744567861 no 2352 0.299899910414229 3285 24824909
SGTC_48 0382-0018 55 µM -0.525469552346338 0.29590965196415 no 2353 0.299628407052418 3548 762596
SGTC_3255 9139072 49.47 µM -0.526831855240708 0.295416244140692 no 2354 0.299155179677664 3407 17646060
SGTC_1097 itavastatin 7.23 µM -0.527549167623702 0.295156595418977 no 2355 0.298906141063859 3386 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1949 st076024 69.1 µM -0.528172139788219 0.294931180735561 no 2356 0.298689932209617 3260 2921930
SGTC_2856 9022925 19.48 µM -0.528554110372962 0.294793008702088 no 2357 0.298557400588248 3392 4944862
SGTC_1491 4138-0063 26.5 µM -0.528961710714961 0.294645598418261 no 2358 0.298416005765547 3382 23883227
SGTC_1363 1636-0063 10.4 µM -0.529314617388969 0.294517995787607 no 2359 0.29829360856394 3360 6072185
SGTC_3086 9117350 49.47 µM -0.529832837906737 0.294330665850169 no 2360 0.298113917663701 3371 2679265
SGTC_907 3448-6986 75.5 µM -0.53184113532948 0.293605212942113 no 2361 0.297418014873272 3472 590582
SGTC_2987 9018338 71.43 µM -0.53193655803985 0.293570764214769 no 2362 0.297384968058083 3469 5055682
SGTC_2811 7967822 32.47 µM -0.532990311013527 0.293190471433923 no 2363 0.297020143669586 3422 2232244
SGTC_1441 4106-0040 13 µM -0.53325257372473 0.29309585799089 no 2364 0.296929376382666 3393 2904180
SGTC_934 2950-0684 338 µM -0.533950984592003 0.29284396958516 no 2365 0.296687723195462 3460 1121253
SGTC_3134 9127454 49.47 µM -0.534663873485206 0.292586963229606 no 2366 0.296441153469959 3472 24262820
SGTC_2178 5812956 200 µM -0.53566108535718 0.292227630424839 no 2367 0.296096401491864 3394 5403383
SGTC_3148 9097893 49.47 µM -0.536855908545375 0.291797361418779 no 2368 0.295683574611012 3295 17174100
SGTC_786 4544-0069 423 µM -0.537262492327327 0.291651013454821 no 2369 0.295543154996979 3408 748821 YLR208W SEC13
SGTC_1458 k015-0034 6.33 µM -0.53796410699659 0.291398550975899 no 2370 0.295300914318436 3375 3598957
SGTC_999 SEC7.066 22.7 µM -0.537995018438686 0.291387430436327 no 2371 0.295290243883024 3361 740511 YDR170C SEC7
SGTC_3352 9151559 45.5865 µM -0.53867303999835 0.291143558748082 no 2372 0.29505623975039 3357 17159339
SGTC_2556 citropten 84.59 µM -0.540392136256295 0.290525659516547 no 2373 0.294463314894163 3352 2775 A potential DNA crosslinker.
SGTC_1550 gossypolone 36.6 µM -0.540785935063941 0.290384201828115 no 2374 0.294327569185281 3410 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_629 3448-6466 76.7 µM -0.541929091935622 0.289973747699241 no 2375 0.293933677346979 3429 573744
SGTC_2696 st077691 74.316 µM -0.5427906214048 0.289664592658426 no 2376 0.29363698563286 3445 757133
SGTC_3037 9091026 49.47 µM -0.543409074468283 0.289442759662554 no 2377 0.293424089579449 3454 25236398 YIL048W NEO1
SGTC_1704 st028805 70.8 µM -0.544593251909557 0.289018229755005 no 2378 0.293016648446575 3407 2876101
SGTC_3068 9116768 49.47 µM -0.548582342662889 0.287590292586346 no 2379 0.291646053085817 3435 41904888
SGTC_2664 lyso-paf C-16 73.48 µM -0.549014075955342 0.287435949311759 no 2380 0.291497895016002 3377 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_196 k015-0023 18.111 µM -0.550927131710214 0.286752509820573 no 2381 0.290841813763262 3402 5211998
SGTC_813 k007-0158 173 µM -0.551455890072772 0.286563746782283 no 2382 0.290660598257281 3409 6523916
SGTC_2776 terbinafine 19.92 µM -0.553448790776368 0.285852825415431 no 2383 0.289978068549506 3441 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_985 1493-0307 8.71 µM -0.554667158239111 0.285418614394389 no 2384 0.289561171878104 3478 3278274
SGTC_1189 1431-2119 7.28 µM -0.555508399442208 0.285118989901228 no 2385 0.289273483276929 3481 3107275
SGTC_2121 5257820 149.641 µM -0.555638513906649 0.285072660483797 no 2386 0.289228998586611 3490 791256
SGTC_20 0481-0013 4.944 µM -0.557426994025889 0.284436206410995 no 2387 0.288617863231907 3436 182045
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.557765474003104 0.284315830319833 no 2388 0.288502270899832 3392 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1453 4237-0541 195 µM -0.558434077373812 0.284078121627179 no 2389 0.288274004175319 3435 739892
SGTC_1402 3909-7673 35.9 µM -0.558764796598001 0.283960576105652 no 2390 0.28816112538982 3441 5328014
SGTC_721 1187-1332 279 µM -0.559015262399559 0.283871570060386 no 2391 0.288075652023453 3379 25730
SGTC_2016 5121758 140 µM -0.561416859406505 0.283018812193146 no 2392 0.287256696727182 3456 2795203
SGTC_3260 9137109 49.47 µM -0.561723561385542 0.282909997216468 no 2393 0.287152189373689 3374 17478346
SGTC_2884 9058502 51.95 µM -0.561935092947416 0.282834959516465 no 2394 0.287080121412072 3470 6471554
SGTC_1082 camptothecin 424.86 nM -0.562493706998398 0.282636845393694 no 2395 0.286889845012575 3289 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2514 salinomycin 42.74 µM -0.565358656180119 0.281621832275348 no 2396 0.285914919807035 3500 23682228 A polyether potassium ionophore.
SGTC_2119 5528445 120.635 µM -0.567308537912205 0.280932022109409 no 2397 0.285252288665921 3484 791935
SGTC_3318 9139014 38.6185 µM -0.568661564487192 0.280453841986173 no 2398 0.284792918119324 3446 16643984
SGTC_955 1216-0110 33 µM -0.569018035602063 0.280327925293802 no 2399 0.284671950207787 3449 3619719
SGTC_1634 st006576 41 µM -0.569413588790507 0.280188235649822 no 2400 0.284537748573268 3508 3915356
SGTC_2297 7971671 152.32 µM -0.569887881219893 0.280020783712655 no 2401 0.284376872465527 3512 909016
SGTC_1019 4262-0212 3.4 µM -0.570051737472279 0.279962944505441 no 2402 0.284321303870286 3499 4677213
SGTC_1564 D-Arginine 115 µM -0.572053075273293 0.279256965135115 no 2403 0.283643009027111 3414 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_127 0180-0333 59.125 µM -0.57294166369793 0.278943789834781 no 2404 0.28334209668818 3484 771601
SGTC_1664 st014217 9.02 µM -0.573368337530627 0.278793473074754 no 2405 0.283197661916609 3531 3982782
SGTC_1272 0839-0021 27 µM -0.576741776804331 0.27760640387665 no 2406 0.282056953177747 3456 5027250
SGTC_2247 cerulenin 830 nM -0.577148420178735 0.27746347833669 no 2407 0.281919598672911 3563 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_639 0833-0042 114 µM -0.578600743842417 0.276953314699098 no 2408 0.281429301358399 3429 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2384 9036245 200 µM -0.579116607310455 0.276772215839414 no 2409 0.281255247477795 3421 6462766
SGTC_767 0929-0023 86 µM -0.579258922166249 0.276722265044415 no 2410 0.281207239167351 3535 1204563
SGTC_1812 st052057 4.327 µM -0.580005855657352 0.276460172862758 no 2411 0.2809553344917 3452 3645418
SGTC_1108 betulinic acid 729.144 nM -0.580016817633059 0.276456327311513 no 2412 0.28095163835765 3451 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2537 larixol 68.93 µM -0.580111564907885 0.276423090281376 no 2413 0.280919692666311 3509 6708759
SGTC_961 1252-1571 372 µM -0.58026127687009 0.276370575816083 no 2414 0.28086921825401 3520 6813498
SGTC_3123 9126162 49.47 µM -0.581355593664373 0.275986870994165 no 2415 0.280500409683673 3484 25239884
SGTC_2839 9003951 25.97 µM -0.581932377453064 0.275784736251828 no 2416 0.280306115373034 3489 2990634
SGTC_672 1441-0018 53.7 µM -0.582365322186774 0.275633057937362 no 2417 0.280160317256106 3426 251141
SGTC_1916 st067606 49.2 µM -0.582704381968287 0.275514300021195 no 2418 0.280046161422642 3451 19590279
SGTC_2212 7123476 200 µM -0.585015853415963 0.274705363206526 no 2419 0.279268528498779 3451 1085715
SGTC_496 calpeptin 138 µM -0.586837095303144 0.274068816180083 no 2420 0.278656560273109 3466 73364 A calpain inhibitor.
SGTC_2430 5571206 200 µM -0.58750098313667 0.273836960392901 no 2421 0.278433645185867 3542 1731771
SGTC_667 1498-1044 59 µM -0.587531472150178 0.273826314757962 no 2422 0.278423409909573 3458 6739982
SGTC_297 0986-0032 24 µM -0.587869726546366 0.273708222574865 no 2423 0.278309868940786 3435 2847425
SGTC_3184 9108758 49.47 µM -0.589313327443294 0.273204512549965 no 2424 0.277825553073942 3496 902885
SGTC_2460 5552655 174.22 µM -0.589633073297059 0.273093007038013 no 2425 0.277718336739527 3498 5401989
SGTC_2077 5212015 200 µM -0.590561236614629 0.272769454898935 no 2426 0.277407221986997 3448 780900
SGTC_428 3448-4153 16.5 µM -0.592274379477701 0.272172763525307 no 2427 0.276833434687297 3418 3834874
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.592484004503394 0.272099795250021 no 2428 0.276763264379566 3625 6728940
SGTC_1737 st035557 69.7 µM -0.592765416089483 0.272001854119563 no 2429 0.276669077794922 3435 5716916
SGTC_2343 7990716 14.84 µM -0.592785576152129 0.271994838381682 no 2430 0.276662330959133 3467 6456862
SGTC_608 k048-0125 159 µM -0.593457855798896 0.271760935413261 no 2431 0.276437389729919 3537 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_374 0880-0231 82.3 µM -0.596355447456889 0.270753937533634 no 2432 0.27546889844247 3504 6833587
SGTC_3331 9141060 1.957 µM -0.596636845678422 0.270656242751067 no 2433 0.275374932870191 3443 4906567 YPR165W RHO1
SGTC_1373 2887-0003 58.5 µM -0.597344418910194 0.270410667933126 no 2434 0.275138727018489 3468 776948
SGTC_2267 7931562 200 µM -0.598189008678308 0.270117685160846 no 2435 0.274856912264712 3419 934880
SGTC_90 0870-0863 4.608 µM -0.599382997659877 0.269703769141479 no 2436 0.274458756158263 3493 1738164
SGTC_1972 st070201 17.4 µM -0.599687581053153 0.269598231152686 no 2437 0.274357233185865 3518 2829099
SGTC_26 0302-0163 425.158 µM -0.602209313636874 0.268725247722154 no 2438 0.273517408420996 3481 3100915
SGTC_923 1900-2434 73.3 µM -0.602695417689481 0.26855712969233 no 2439 0.273355665246428 3500 5910570
SGTC_3055 9094636 49.47 µM -0.60341874503924 0.268307066398911 no 2440 0.27311507760975 3582 25236176
SGTC_1126 isoteolin 1.0172 µM -0.604124638769644 0.268063143101696 no 2441 0.272880389831334 3512 133323
SGTC_1862 st057513 3.81 µM -0.607352009859176 0.266949340985851 no 2442 0.271808664686603 3499 5393163
SGTC_2774 tamoxifen 10.92 µM -0.60855223031733 0.266535728496843 no 2443 0.271410637992825 3566 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2782 7736369 71.43 µM -0.608892995036878 0.266418355385094 no 2444 0.271297683827335 3533 2950836 YOL077C BRX1
SGTC_1933 st074711 15.9 µM -0.609422992296401 0.266235854933385 no 2445 0.271122050831904 3527 17250958
SGTC_1222 0366-0074 1.18 µM -0.609477003634414 0.266217260101207 no 2446 0.27110415548366 3559 286520
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.609880358706266 0.266078415236886 no 2447 0.270970532181799 3494 688664
SGTC_2719 novobiocin 32.65 µM -0.610379220525192 0.265906745312582 no 2448 0.270805314907496 3560 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_328 k915-0120 63.5 µM -0.611923235383797 0.265375769883026 no 2449 0.270294273894711 3525 6624543
SGTC_1437 4092-1038 11.6 µM -0.61515251168681 0.264266987699067 no 2450 0.269227002927956 3533 3977136
SGTC_2149 5554786 194.827 µM -0.617769600055629 0.263370135948579 no 2451 0.268363612633188 3528 745063 YPR165W RHO1
SGTC_2065 5221596 34.26 µM -0.617930546924215 0.263315031726156 no 2452 0.268310560959638 3540 788581
SGTC_696 1560-0013 611 µM -0.62224742150763 0.261839240718506 no 2453 0.266889594168085 3614 1650269
SGTC_1803 st050068 52.4 µM -0.622991442903674 0.261585314655619 no 2454 0.26664507253924 3641 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3147 9097027 49.47 µM -0.6241430652002 0.261192528411709 no 2455 0.26626681688811 3532 25236841
SGTC_457 grayanotoxin iii 135 µM -0.624603079413306 0.261035715150246 no 2456 0.266115799047168 3540 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1090 efavirenz 20.7 µM -0.625695153508913 0.260663634291773 no 2457 0.26575745636736 3571 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3010 9080089 71.4286 µM -0.627875299933498 0.259921653274135 no 2458 0.265042816447605 3575 17027233
SGTC_2528 xanthyletin 44.79 µM -0.6280902342523 0.259848562554746 no 2459 0.26497241507394 3566 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2323 6148992 148.28 µM -0.629311668201135 0.259433402287641 no 2460 0.264572516959171 3495 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_353 1988-1175 58.3 µM -0.629545860568776 0.259353840448078 no 2461 0.264495877349374 3436 2788357
SGTC_5 0352-0601 109.883 µM -0.629744320038292 0.259286427964314 no 2462 0.264430940198571 3486 762456
SGTC_223 busulfan 5 mM -0.631994084198995 0.258522864285908 no 2463 0.263695371428354 3545 2478 A DNA alkylator.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.634170555636941 0.257785285784409 no 2464 0.262984760562472 3564 6708784 An antioxidant flavonoid
SGTC_3154 9100113 49.47 µM -0.634589466513108 0.257643447657817 no 2465 0.262848099938604 3525 25237525
SGTC_1700 st030840 7.9285 µM -0.634594537918555 0.257641730789914 no 2466 0.26284644572464 3571 5499307
SGTC_194 1486-1323 56.904 µM -0.634623692929062 0.257631860800647 no 2467 0.262836935914737 3546 5178754
SGTC_2983 9022671 12.99 µM -0.634916379627159 0.257532787011509 no 2468 0.262741476831077 3574 6405161
SGTC_1914 st062367 72.6 µM -0.635716399543896 0.257262083072427 no 2469 0.26248064271968 3548 978205
SGTC_1215 3852-0577 11.2 µM -0.637048477445231 0.256811674268777 no 2470 0.262046633640927 3629 2884876
SGTC_1852 st056254 31.4 µM -0.637899999899516 0.256523968454266 no 2471 0.261769388911353 3523 442583
SGTC_3311 9131146 2.8755 µM -0.638560509689265 0.256300916204628 no 2472 0.261554439119942 3542 4900406 YPR165W RHO1
SGTC_1181 1222-0449 220 µM -0.639436990958279 0.256005087168351 no 2473 0.261269345653103 3640 658318
SGTC_228 caffeine 993.056 µM -0.64022710690768 0.255738560813838 no 2474 0.261012481172729 3578 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2507 purpurin 79.67 µM -0.64112026549981 0.255437450069813 no 2475 0.260722274242516 3527 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2799 7812892 81.82 µM -0.641167461757786 0.255421543940373 no 2476 0.260706943757219 3583 20205235
SGTC_2770 toltrazuril 17.5 µM -0.643238259066569 0.254724151682566 no 2477 0.260034755739089 3585 68591 Kills coccidiodes.
SGTC_136 0097-0015 404.482 µM -0.643348386592453 0.254687091453182 no 2478 0.259999033003496 3613 4861337
SGTC_1801 st050089 28.441 µM -0.644784820338112 0.25420395999859 no 2479 0.259533320137451 3603 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_122 0236-0016 402.397 µM -0.647162422386168 0.253405332456847 no 2480 0.258763414402115 3642 6808838
SGTC_3223 9129970 49.47 µM -0.647547131135449 0.253276234301907 no 2481 0.258638950726358 3636 17248386
SGTC_579 4491-1009 110 µM -0.649087858880167 0.252759553288515 no 2482 0.258140794483956 3721 1271041
SGTC_2714 st079313 56.9 µM -0.64914983269189 0.25273878206957 no 2483 0.258120767196169 3599 2939799
SGTC_2784 7567673 72.73 µM -0.652512774425625 0.25161300343485 no 2484 0.25703521737175 3628 3471247
SGTC_2419 paclitaxel 166.5 µM -0.652687993580139 0.251554419746743 no 2485 0.256978722191037 3559 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1141 3253-0389 52.6 µM -0.655143557682618 0.250734172360066 no 2486 0.256187665058824 3585 5402031
SGTC_903 1134-0042 114 µM -0.655201275655753 0.250714909516675 no 2487 0.256169086565539 3586 701009
SGTC_2317 5986382 200 µM -0.656757590467985 0.250195799348182 no 2488 0.255668398688628 3645 877883
SGTC_3237 9133362 49.47 µM -0.657095365701294 0.250083209453936 no 2489 0.255559799281381 3566 43845137
SGTC_2596 sinensetin 100 µM -0.65731238602901 0.25001088471867 no 2490 0.255490036962233 3574 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2378 9074213 121.43 µM -0.659467504737497 0.249293267249487 no 2491 0.254797803146029 3608 657714
SGTC_3000 9075062 71.4286 µM -0.65968171543815 0.249221998654782 no 2492 0.254729051392252 3590 17057871
SGTC_926 2268-1401 59.4 µM -0.659696116871831 0.249217207639827 no 2493 0.254724429544846 3609 2931578
SGTC_2819 7996655 46.38 µM -0.659923422750835 0.249141594860131 no 2494 0.25465148615969 3500 6456960
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.661054718606875 0.248765453451103 no 2495 0.254288611472465 3605 5379071
SGTC_2168 5727979 200 µM -0.66107628714899 0.248758285125118 no 2496 0.254281695776977 3554 695210
SGTC_1462 k081-0014 26.5 µM -0.661271319014203 0.248693471088813 no 2497 0.254219165615528 3433 3270634
SGTC_1311 1190-0148 100 µM -0.661612792682553 0.248580012388114 no 2498 0.254109703420624 3661 1961333
SGTC_3062 9077494 49.47 µM -0.662292062247826 0.248354398979954 no 2499 0.253892031495199 3590 16459633
SGTC_1273 0849-0096 14.1 µM -0.664280060835696 0.247694730443309 no 2500 0.253255540130062 3626 5286025
SGTC_29 0299-0004 12.984 µM -0.664537724033869 0.247609299786517 no 2501 0.253173106360665 3521 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2157 5649910 96.377 µM -0.667674834409727 0.24657042490675 no 2502 0.252170588631675 3604 2858091
SGTC_3139 9095020 49.47 µM -0.667756895790167 0.246543281109884 no 2503 0.252144392631407 3448 25236292
SGTC_2199 6590217 200 µM -0.667991512694898 0.246465684695951 no 2504 0.252069505094482 3574 703109
SGTC_3156 9099931 49.47 µM -0.668250845453639 0.246379929072225 no 2505 0.251986742141779 3636 18111053
SGTC_15 0266-0086 27.098 µM -0.668976057176107 0.246140202465832 no 2506 0.251755375620741 3705 1712902 YIL048W NEO1
SGTC_2564 betulinic acid 100 µM -0.671032448743611 0.245461120750973 no 2507 0.251099929188267 3661 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3188 9110789 49.47 µM -0.671790695405919 0.245210979395523 no 2508 0.250858476523493 3653 849217
SGTC_3035 9091303 49.47 µM -0.672179636303106 0.245082723161301 no 2509 0.250734671637215 3656 25237002
SGTC_346 4513-0042 7.16 µM -0.672191606443571 0.245078776488383 no 2510 0.250730861900945 3631 2827372
SGTC_2593 nobiletin 86.24 µM -0.672200868941021 0.245075722575429 no 2511 0.250727913947179 3588 72344 An anti-infammatory.
SGTC_1779 st039427 55 µM -0.672810478329376 0.244874774927059 no 2512 0.250533935331821 3676 1124498
SGTC_692 k241-0027 77.8 µM -0.673375478766557 0.244688611087314 no 2513 0.250354222376464 3678 3600480
SGTC_2907 7721985 69.9 µM -0.674120974082866 0.244443092058719 no 2514 0.250117202982368 3598 3267881
SGTC_14 0354-0009 295 µM -0.677012717854302 0.243491991794728 no 2515 0.249198942614103 3675 1713507
SGTC_2965 9082772 38.63 µM -0.677360888777573 0.243377612675087 no 2516 0.2490885035405 3660 16459634
SGTC_1596 piperlongumine 63 µM -0.678649751314652 0.242954455709611 no 2517 0.248679905790169 3656 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2457 5731572 11.68 µM -0.678690037711757 0.242941235372206 no 2518 0.248667139872659 3675 2865357
SGTC_738 1315-0003 72.4 µM -0.682330491188879 0.241748196483129 no 2519 0.247514998451896 3648 6251474
SGTC_1130 3454-2858 15.9 µM -0.682509069001957 0.241689755406789 no 2520 0.247458555099553 3634 715628 YIL048W NEO1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.682960103169852 0.241542184870955 no 2521 0.247316026696192 3707 5024745
SGTC_2932 9016711 44.54 µM -0.683903569614835 0.241233657344346 no 2522 0.247018029907781 3629 7117328
SGTC_2466 5983409 37.09 µM -0.684340532992171 0.241090836440047 no 2523 0.246880078796145 3634 2879657
SGTC_2898 9056270 58.44 µM -0.686686095106481 0.240324978860699 no 2524 0.24614028059107 3596 19154699
SGTC_2088 5278280 127.392 µM -0.687806485811453 0.239959624524349 no 2525 0.245787325631855 3698 791502
SGTC_1041 0206-0046 107 µM -0.688532871409225 0.239722915413838 no 2526 0.245558638758595 3657 50494
SGTC_1953 st076800 12.1 µM -0.689884769598441 0.239282708384854 no 2527 0.245133327200758 3645 297591
SGTC_2976 9009005 19.48 µM -0.690464086572441 0.239094205616931 no 2528 0.24495119353087 3680 2993148
SGTC_2975 9084847 53.72 µM -0.690601746601811 0.239049424639295 no 2529 0.244907924779277 3678 27211724
SGTC_1620 st003704 16.5 µM -0.69108482690472 0.238892314301768 no 2530 0.244756117451445 3641 2834414
SGTC_400 oxethazaine 37.5 µM -0.691186809163782 0.238859154226742 no 2531 0.244724076142512 3643 4621 A local anesthetic.
SGTC_1357 1503-1303 39.5 µM -0.691383886229683 0.238795080702164 no 2532 0.244662163859095 3672 292895
SGTC_666 0272-0154 136 µM -0.691468789458277 0.238767479936225 no 2533 0.244635493884194 3698 6870312
SGTC_869 0564-0080 44.1 µM -0.69151757228629 0.238751622160149 no 2534 0.244620170831245 3666 6843321
SGTC_2508 celastrol 40.54 µM -0.692153132268657 0.23854507409328 no 2535 0.244420583906795 3621 122724 Celastrol is a natural product and antioxidant.
SGTC_2314 7727897 200 µM -0.692460941249608 0.238445075665893 no 2536 0.244323953221202 3662 900724
SGTC_1474 0330-0125 5.35 µM -0.693002343191562 0.238269245198225 no 2537 0.244154040506806 3671 X1474
SGTC_2242 6630449 61.2675 µM -0.693518949264013 0.238101533897365 no 2538 0.243991969114005 3679 691249 YDR170C SEC7
SGTC_1359 1582-0056 520 nM -0.694769539288987 0.237695809605809 no 2539 0.243599870232779 3709 3661189
SGTC_466 geldanamycin 89.2 µM -0.696830123718435 0.237028129956109 no 2540 0.242954555859857 3568 5288382 HSP90 inhibitor.
SGTC_2319 6033012 152.6 µM -0.696882527926718 0.23701116316403 no 2541 0.2429381564722 3644 847246
SGTC_1266 0828-0227 32.9 µM -0.697395853477752 0.23684500020838 no 2542 0.24277754789909 3656 3913820
SGTC_3185 9108267 49.47 µM -0.70143366985338 0.235540199254933 no 2543 0.241516207883689 3640 4910486
SGTC_2245 6637752 200 µM -0.701649797639135 0.235470470597537 no 2544 0.241448794005998 3665 681890
SGTC_3049 9092223 49.47 µM -0.702070388175251 0.235334809395937 no 2545 0.24131763407444 3646 8623917
SGTC_3001 9076041 71.4286 µM -0.702096296963109 0.23532645394437 no 2546 0.241309555760601 3688 16004211
SGTC_760 0568-0725 82.9 µM -0.70262712341416 0.23515530118254 no 2547 0.241144077371223 3698 3916171
SGTC_1674 st016616 23.6 µM -0.703284981904532 0.234943285292191 no 2548 0.240939083988409 3674 625830
SGTC_325 2810-4341 181 µM -0.70342833591066 0.234897098909803 no 2549 0.240894426441803 3681 774970
SGTC_2937 9044753 11.33 µM -0.703528929679167 0.234864692192509 no 2550 0.240863092225106 3693 6465530 YGL099W LSG1
SGTC_2037 5169046 200 µM -0.704778629338945 0.234462302145563 no 2551 0.240474004944325 3708 5718022
SGTC_1008 4106-0037 6 µM -0.704915503808242 0.234418253204659 no 2552 0.240431410620705 3655 2905394
SGTC_784 4579-0127 173 µM -0.704930160369272 0.234413536701709 no 2553 0.240426849850772 3782 1948547
SGTC_1122 capsaicin 818.572 nM -0.705544176257415 0.234215992669478 no 2554 0.240235825190443 3751 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1865 st057639 52.2 µM -0.705553834252323 0.234212886191078 no 2555 0.240232821181149 3685 688818
SGTC_2054 5233173 129 µM -0.706064191169276 0.234048763170832 no 2556 0.240074109600274 3702 6889
SGTC_2137 5261020 140 µM -0.707615464968163 0.233550288398201 no 2557 0.239592043219749 3663 763655
SGTC_1855 st056195 39.6 µM -0.707942384150014 0.233445313785665 no 2558 0.239490518841281 3641 4028379
SGTC_3125 9127534 49.47 µM -0.708252112909858 0.233345883213268 no 2559 0.239394354602113 3565 1639235
SGTC_2325 6158266 200 µM -0.709377044347682 0.232984950208774 no 2560 0.239045264606605 3709 3623240
SGTC_1650 st011916 45.8 µM -0.709479450393955 0.232952108747077 no 2561 0.239013499671746 3666 242528
SGTC_2059 5238311 157 µM -0.713245927832413 0.231745993230983 no 2562 0.237846795373095 3700 703021
SGTC_1843 st055809 45.5 µM -0.714187580785054 0.231444998163858 no 2563 0.237555597667481 3695 16413835
SGTC_150 3970-0969 77.2 µM -0.718361060636173 0.230113591730157 no 2564 0.236267344912692 3777 6615640
SGTC_2880 9042983 58.44 µM -0.719664403691614 0.229698684313217 no 2565 0.235865824006679 3709 6464714
SGTC_1504 k297-0033 30 µM -0.720419185676999 0.229458598037255 no 2566 0.235633470416087 3621 4388117
SGTC_79 0052-0007 94.094 µM -0.720439491459957 0.229452140976509 no 2567 0.235627221187868 3725 2801472
SGTC_137 0438-0332 85.389 µM -0.721004671787354 0.229272459460154 no 2568 0.235453320192578 3738 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1346 1488-2224 62.4 µM -0.723358333693906 0.22852503479271 no 2569 0.23472988139718 3697 3722427
SGTC_1227 3909-8010 46.6 µM -0.723985459700139 0.228326116958976 no 2570 0.23453733090059 3702 15982272
SGTC_1877 wortmannin 25 µM -0.724760197915062 0.228080512492047 no 2571 0.234299578774853 3716 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1825 st052143 62.6 µM -0.72482309791093 0.228060578705319 no 2572 0.234280281843263 3727 674173
SGTC_1071 trifluoperazine 6.31 µM -0.725441904162548 0.227864523592336 no 2573 0.234090486735773 3793 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_661 1304-0007 33.6 µM -0.725551837185168 0.227829703661713 no 2574 0.23405677790287 3726 3117130
SGTC_2018 5133068 143 µM -0.72584418674973 0.227737120108981 no 2575 0.23396714765167 3714 785362
SGTC_119 0121-0043 24.815 µM -0.728789227112983 0.22680564364481 no 2576 0.233065301175144 3797 1092378
SGTC_2468 5987765 72.9 µM -0.728805759672994 0.226800420693729 no 2577 0.233060243937854 3761 26772094
SGTC_508 roscovitine 141 µM -0.730635042148703 0.226222934761878 no 2578 0.232501051007154 3769 160355 A CDKinase inhibitor.
SGTC_25 0118-0223 35.662 µM -0.731644198949412 0.225904710103753 no 2579 0.232192881714006 3745 5333628
SGTC_960 1222-0186 7.7 µM -0.733100561590138 0.225445911357865 no 2580 0.231748548821985 3748 3126296
SGTC_2442 5158906 48.48 µM -0.733616981328874 0.225283350128063 no 2581 0.231591104198457 3740 1893835
SGTC_308 4092-1169 104 µM -0.734868541649052 0.224889653129149 no 2582 0.231209779389713 3686 2268590 YDL196W YDL196W
SGTC_1572 epiandrosterone 68.9 µM -0.735275062430436 0.224761859908464 no 2583 0.23108599624063 3669 441302 A steroid.
SGTC_1051 3253-3903 78 µM -0.73606325928159 0.224514200971028 no 2584 0.2308461004154 3739 5509239
SGTC_1118 chelidonine 707.474 nM -0.736366629232867 0.224418920533847 no 2585 0.23075380372674 3729 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2485 5633444 17.78 µM -0.736868789870881 0.224261255670565 no 2586 0.230601072650763 3747 5724239
SGTC_1234 0326-0494 15.5 µM -0.736900551937325 0.224251285355628 no 2587 0.230591414186503 3766 1547813
SGTC_1510 1123-0200 71.5 µM -0.737601777671335 0.224031230255396 no 2588 0.230378237428837 3772 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1994 st072947 40.9 µM -0.738043356569794 0.223892719178391 no 2589 0.230244051401307 3777 5286565 YDL195W SEC31
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.738415716112961 0.223775958127839 no 2590 0.230130933580062 3732 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_184 1494-0393 24.714 µM -0.738687488688035 0.223690760061078 no 2591 0.230048392358307 3724 3090647
SGTC_2601 securinine 100 µM -0.740226442198648 0.22320866111275 no 2592 0.229581302784542 3706 442872 A GABA receptor antagonist.
SGTC_1038 k292-0204 154 µM -0.740549574548571 0.223107510519248 no 2593 0.229483296044255 3695 4454212
SGTC_620 0109-0052 432 µM -0.741048713385421 0.222951315664503 no 2594 0.22933195224524 3715 493037
SGTC_1613 st002381 52.1 µM -0.741845285875925 0.222702174357181 no 2595 0.229090539582002 3714 551167
SGTC_831 k061-1017 217 µM -0.742678387952385 0.222441777660083 no 2596 0.228838208684381 3800 1240153
SGTC_1940 st075990 51.1 µM -0.742831235486928 0.222394022069474 no 2597 0.228791930992439 3823 1084979
SGTC_654 1124-0271 80.9 µM -0.742851195364119 0.222387786249326 no 2598 0.228785888122532 3738 5403748
SGTC_46 0329-0187a 2.197 µM -0.74356272389367 0.222165557256031 no 2599 0.228570530785882 3795 46494817
SGTC_2153 5569715 200 µM -0.748012804843368 0.220778558759587 no 2600 0.227226216991496 3755 2054701
SGTC_2709 st078560 56 µM -0.748841623574722 0.220520781925975 no 2601 0.22697633437376 3742 17250903
SGTC_856 0433-0016 11.3 µM -0.749328657130603 0.220369386624218 no 2602 0.226829569734136 3801 3911780
SGTC_2934 9036370 36.88 µM -0.749949237794371 0.220176564305117 no 2603 0.226642639068108 3766 6462800
SGTC_2147 5545932 89.7195 µM -0.753063922193218 0.219210254910792 no 2604 0.225705751456162 3777 797404
SGTC_1289 0976-0073 69.1 µM -0.754413226335079 0.218792400578943 no 2605 0.225300566030716 3802 3391136
SGTC_2499 avocadenofuran 51.48 µM -0.75477532029562 0.218680344882836 no 2606 0.225191902205566 3755 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2081 5214970 32.255 µM -0.754885328357744 0.218646307693712 no 2607 0.225158894840762 3693 2063512
SGTC_680 0417-1641 114 µM -0.755494066205617 0.218458015495923 no 2608 0.224976295668973 3751 2835990
SGTC_3346 9158254 43.5805 µM -0.75569907276479 0.218394624766609 no 2609 0.224914820068689 3768 17639500
SGTC_953 1188-0045 9.7 µM -0.755894541265141 0.218334193198903 no 2610 0.224856213528231 3772 6144426
SGTC_2695 st077686 51.995 µM -0.756356001455734 0.218191565145283 no 2611 0.224717890111969 3809 2876092
SGTC_1187 1391-0724 117 µM -0.756437831404508 0.218166278761694 no 2612 0.224693366494841 3837 6997986
SGTC_363 0455-0021 3.06 µM -0.757455741621134 0.217851874140601 no 2613 0.224388435889598 3777 4597466
SGTC_2271 7849410 118.62 µM -0.758253255463187 0.217605726609452 no 2614 0.224149692587161 3723 972430
SGTC_322 k048-0136 19.3 µM -0.759054515859583 0.217358584436582 no 2615 0.223909973065616 3805 6823282
SGTC_1298 1079-1278 263 µM -0.759112919233931 0.217340576736201 no 2616 0.22389250575639 3801 2840950
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.759192116740285 0.217316158890435 no 2617 0.223868820565241 3796 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_613 3914-0030 117 µM -0.759629569087091 0.217181313947886 no 2618 0.223738019598821 3523 1145395
SGTC_913 3487-1245 167 µM -0.759769249195742 0.21713826765535 no 2619 0.223696263532566 3731 4016153
SGTC_2931 9014674 55.67 µM -0.761873078869268 0.216490510785228 no 2620 0.223067879444798 3791 2996810
SGTC_89 0302-0250 142.109 µM -0.762035678167897 0.216440494002053 no 2621 0.223019355221995 3839 4203518 YLR208W SEC13
SGTC_2605 digitonin 300 nM -0.762426792127221 0.216320211760539 no 2622 0.222902660395133 3794 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3256 9138902 49.47 µM -0.763162844759823 0.216093952876158 no 2623 0.222683142201082 3793 17228773
SGTC_1196 1588-0294 184 µM -0.763752358910324 0.215912838077679 no 2624 0.222507416119188 3787 6144269
SGTC_2521 angolensin 13.4 µM -0.764247837830391 0.215760681516235 no 2625 0.222359781829891 3812 821428 A flavenoid.
SGTC_2971 9092186 9.93 µM -0.76451409503202 0.21567894230514 no 2626 0.222280470174231 3802 25236400
SGTC_994 3910-0338 138 µM -0.766249331258625 0.215146676129976 no 2627 0.221763980308049 3868 3479481
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.767182474170532 0.214860759540956 no 2628 0.221486515757897 3766 2333 A French combination drug.
SGTC_2259 7964009 200 µM -0.767423665071203 0.214786894149055 no 2629 0.22141483135405 3799 313134
SGTC_544 k015-0020 52.4 µM -0.76822916662244 0.214540313972212 no 2630 0.221175524202039 3794 3008304
SGTC_2646 retinol 96.75 µM -0.769067202332525 0.214283949192229 no 2631 0.220926708579086 3767 445354 A vitamin A analog and teratogen.
SGTC_1591 genipin 88.4 µM -0.76922243377331 0.21423648167459 no 2632 0.22088063743739 3808 442424 A DNA cross-linking agent.
SGTC_22 0964-0034 14.468 µM -0.770973347909372 0.21370150136289 no 2633 0.220361364659825 3792 138402
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.771109389920807 0.213659967225728 no 2634 0.220321047675968 3796 6708739 YPR165W RHO1
SGTC_891 0929-0073 133 µM -0.771673395967827 0.21348782423077 no 2635 0.220153945727842 3856 5603632
SGTC_2872 9044037 25.97 µM -0.7718530258089 0.213433015520005 no 2636 0.220100740825869 3779 6465195
SGTC_2000 st075254 36.4 µM -0.771895569296444 0.213420035839743 no 2637 0.220088140870267 3749 17234175
SGTC_172 1112-0046 2.638 µM -0.774978675263588 0.212480630180918 no 2638 0.219176130267971 3765 2802135 YIL048W NEO1
SGTC_2306 7482397 179.52 µM -0.775093071944877 0.2124458206735 no 2639 0.219142332551752 3776 891448
SGTC_1336 1486-0901 104 µM -0.775422957117156 0.212345459318921 no 2640 0.219044887017238 3817 5006114
SGTC_1783 st039459 87.517 µM -0.775759686196888 0.212243044414296 no 2641 0.218945445549699 3907 729761
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.776399963466706 0.212048386113969 no 2642 0.218756433110385 3838 279621
SGTC_1548 st061468 90.8 µM -0.778223483563745 0.211494568508991 no 2643 0.218218637444126 3789 390799
SGTC_2437 5741531 144.16 µM -0.778565589220911 0.211390762723947 no 2644 0.218117827997663 3828 2262990
SGTC_1539 benzyladenosine 56 µM -0.778812862588856 0.211315750667906 no 2645 0.218044979822145 3770 92208 A nucleotide analog.
SGTC_464 bw-b 70c 158 µM -0.77961889763443 0.211071342740848 no 2646 0.217807614598104 3864 5353454
SGTC_2381 9035592 200 µM -0.779952811816543 0.210970141019118 no 2647 0.21770932556105 3831 4749657
SGTC_1864 st057645 30.4 µM -0.780243969919237 0.210881920904691 no 2648 0.217623642843459 3827 688666
SGTC_651 3253-0966 34.4 µM -0.780869409293837 0.21069248763303 no 2649 0.217439652828485 3830 781462
SGTC_747 3448-8087 38.7 µM -0.782706101076088 0.210136767211892 no 2650 0.216899859331733 3836 5168703
SGTC_2763 lisinopril 49.32 µM -0.783680816741605 0.209842201472375 no 2651 0.216613710731302 3740 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_405 ebelactone b 50 µM -0.783853049963185 0.209790176660387 no 2652 0.216563170703039 3782 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1906 st060206 94.7 µM -0.785486994594854 0.20929700422925 no 2653 0.216084046293267 3794 5133468
SGTC_2361 9034121 116 µM -0.787728336204289 0.20862161273147 no 2654 0.215427813577484 3808 6496917
SGTC_1573 oleylamine 1.06 µM -0.789903093301683 0.207967515099489 no 2655 0.214792182368952 3836 5356789 An amine of the fatty acid oleic acid.
SGTC_2258 7960471 200 µM -0.790045558667011 0.20792470835585 no 2656 0.214750581100083 3827 2974708
SGTC_2843 9000894 45.46 µM -0.790721617585078 0.207721643034275 no 2657 0.214553229170287 3739 2242070
SGTC_718 1130-0073 349 µM -0.791164972463714 0.207588537795255 no 2658 0.214423864367025 3857 6740020
SGTC_2301 7769476 200 µM -0.791460315442455 0.207499897078634 no 2659 0.21433771256018 3872 977820
SGTC_940 3232-1287 54.8 µM -0.791585404439984 0.207462361104745 no 2660 0.214301230059513 3744 1585493 YIL048W NEO1
SGTC_1037 k284-1091 78.7 µM -0.792229065528234 0.207269278524186 no 2661 0.214113561907726 3782 3334711
SGTC_1092 toremifene 6.32 µM -0.79276972446475 0.207107176217573 no 2662 0.213955999366721 3807 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_335 4077-0256 27.6 µM -0.793078865157995 0.207014522254166 no 2663 0.213865937802094 3808 3121989
SGTC_2708 st078559 56 µM -0.793703859698066 0.206827277230965 no 2664 0.213683926379323 3789 17250902
SGTC_248 streptozotocin 5.23457 mM -0.79439176612109 0.206621300088636 no 2665 0.213483698060297 3823 5300 DNA alkylating agent.
SGTC_192 3455-0609 60.9 µM -0.794579941292929 0.206564976697906 no 2666 0.213428945130776 3896 3769639
SGTC_1991 st073000 8.92 µM -0.796137634997961 0.20609908708658 no 2667 0.212976020723212 3898 4301969 YIL048W NEO1
SGTC_3310 9130229 44.1445 µM -0.79953324313548 0.205085658822643 no 2668 0.211990639347582 3906 7761258
SGTC_1043 0916-0009 19.3 µM -0.799895230048935 0.204977797837737 no 2669 0.211885750825131 3838 3101130
SGTC_796 1234-0020 70.7 µM -0.802456259530473 0.204215653482337 no 2670 0.211144540310869 3765 46495034
SGTC_2434 5670830 169.91 µM -0.805774404138917 0.203230710686806 no 2671 0.210186469563721 3880 1549830
SGTC_3321 9137793 26.8275 µM -0.806086363255535 0.203138256217432 no 2672 0.210096526961261 3807 4904192
SGTC_951 1171-0579 82.7 µM -0.806598300500249 0.202986589200869 no 2673 0.209948976602403 3811 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1452 4194-0072 190 µM -0.807280881773162 0.202784472248671 no 2674 0.209752338045048 3842 1343545
SGTC_2560 caryophyllene 100 µM -0.808748586993289 0.202350282202905 no 2675 0.209329887276682 3888 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1013 4112-3890 241 µM -0.810610943343657 0.201800143900267 no 2676 0.208794565201246 3805 705171
SGTC_2465 5809242 33.21 µM -0.810618430248286 0.201797934084761 no 2677 0.208792414769086 3858 2731748
SGTC_1641 st009299 47.1 µM -0.811321534292605 0.201590472287451 no 2678 0.208590523317419 3766 4046054
SGTC_1820 st053765 18.6 µM -0.813044628759442 0.201082586998802 no 2679 0.208096235582138 3868 3690829
SGTC_2827 7993847 71.43 µM -0.815752048672474 0.200286121995313 no 2680 0.207320981800712 3908 2985692
SGTC_1409 3909-8004 61.9 µM -0.816708708562117 0.200005146967129 no 2681 0.207047456705175 3860 2119279
SGTC_2093 5331342 194.4 µM -0.817276409369231 0.199838522957018 no 2682 0.206885242523109 3909 33839
SGTC_391 gliotoxin 8.33 µM -0.817880925010509 0.199661185364022 no 2683 0.206712591635022 3950 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3258 9138477 49.47 µM -0.818359037691438 0.199520995775036 no 2684 0.206576102126562 3899 4970355
SGTC_2752 diclazuril 33.15 µM -0.818890931603323 0.199365106383632 no 2685 0.20642432212931 3867 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.819272791575935 0.199253234718656 no 2686 0.206315396222793 3856 676296 Flavone; oxidizing agent.
SGTC_2792 7535235 81.82 µM -0.822566342762357 0.198289909161842 no 2687 0.205377322537999 3871 1281891
SGTC_987 1497-1013 404 µM -0.822897177532815 0.198193299430892 no 2688 0.205283233950509 3832 1676435
SGTC_219 mitoxanthrone 164.414 µM -0.823508389011027 0.198014889393091 no 2689 0.205109474292588 3837 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3229 9132204 49.47 µM -0.824459887912716 0.197737343996966 no 2690 0.204839149260669 3884 17682924
SGTC_2618 avocadyne 43.43 µM -0.825084969336274 0.19755514024696 no 2691 0.204661676240019 3801 3015189
SGTC_663 1486-0733 13.9 µM -0.825242412798612 0.197509263369863 no 2692 0.204616989342759 3884 722445 YPR165W RHO1
SGTC_1192 1488-0095 21.4 µM -0.825254367346999 0.197505780240673 no 2693 0.204613596541744 3920 915875
SGTC_1973 st070275 50.2 µM -0.825612678419416 0.197401398408288 no 2694 0.204511920393886 3762 17118334
SGTC_2129 girgensonine 121.053 µM -0.827913975845559 0.196731788664123 no 2695 0.203859609722293 3907 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_677 0929-0063 136 µM -0.828976273992136 0.196423155838799 no 2696 0.203558916457113 3844 1539583
SGTC_2128 5255449 168.493 µM -0.8306744353542 0.195930393581965 no 2697 0.203078786043144 3873 736008
SGTC_2440 5628896 157.78 µM -0.832026816175447 0.195538504848233 no 2698 0.202696904142099 3887 5522048
SGTC_2643 anethole 100 µM -0.834646158529663 0.194780834917639 no 2699 0.201958482432017 3882 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_707 0865-0008 204 µM -0.837267485373063 0.19402438147947 no 2700 0.201221115696837 3884 723043
SGTC_193 1273-0060 1.558 µM -0.837274810945312 0.194022270002385 no 2701 0.201219057312745 3740 2847393 YHR072W ERG7
SGTC_1070 indatraline 8.81 µM -0.837854734935242 0.193855160769299 no 2702 0.201056146786511 3865 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_693 4161-2696 114 µM -0.83908124923228 0.19350202101822 no 2703 0.200711858729599 3919 805759
SGTC_1530 rhein 70.4 µM -0.839200041626228 0.193467838998278 no 2704 0.20067853198099 3937 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3003 9075612 71.4286 µM -0.839451369491947 0.193395532586223 no 2705 0.200608033866074 3913 6501993
SGTC_99 0109-0120 622.8 µM -0.839838323263279 0.193284239173168 no 2706 0.200499521410652 3883 759414
SGTC_827 3253-0474 693 µM -0.840256537590502 0.193163998739307 no 2707 0.200382282283877 3881 5402065
SGTC_3267 9137951 49.47 µM -0.840773576700529 0.19301540841589 no 2708 0.200237396287318 3903 16643986
SGTC_1353 1498-1206 8.11 µM -0.840836911528916 0.192997211608808 no 2709 0.20021965277179 3932 6756808
SGTC_855 0428-0020 25 µM -0.842515691254531 0.192515261332622 no 2710 0.199749680174641 3905 6812414
SGTC_1838 st055369 84.5 µM -0.843440750261939 0.192250006661867 no 2711 0.199490994725015 3882 676036
SGTC_292 k038-0015 474 µM -0.844183353465023 0.192037231853309 no 2712 0.199283477587682 3875 46368540
SGTC_1677 st019204 53.9 µM -0.844472623014232 0.19195438774586 no 2713 0.199202677702899 3931 3945625
SGTC_304 1310-0298 97 µM -0.844579979494159 0.191923647415246 no 2714 0.199172695498618 3791 1550234
SGTC_323 4013-0906 34.3 µM -0.845180740962406 0.19175168168701 no 2715 0.19900496676136 3921 2910086
SGTC_1007 4101-0031 70 µM -0.845733321390149 0.191593590933561 no 2716 0.198850765034368 3846 1146276
SGTC_1381 2324-0066 62.1 µM -0.846547765677582 0.191360727723085 no 2717 0.198623619581457 3962 10885928
SGTC_220 paclitaxel 373.376 µM -0.846953038155921 0.191244918217213 no 2718 0.198510648940525 3846 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_360 0957-0399 1.01 µM -0.847335831066913 0.19113557187268 no 2719 0.19840398013496 3933 6752301 YPR165W RHO1
SGTC_3342 9147791 14.508 µM -0.850554792294194 0.190217579873206 no 2720 0.1975083556161 3826 1838168
SGTC_3345 9148410 3.559 µM -0.851431180872726 0.189968118934158 no 2721 0.19726493849932 3872 4903596
SGTC_1970 st070122 35.8 µM -0.851630552700518 0.189911396533289 no 2722 0.197209588280062 3923 102928
SGTC_965 1291-5240 308 µM -0.85505800019741 0.18893789734669 no 2723 0.196259519673134 3908 2834598
SGTC_820 1582-0060 59.9 µM -0.855663941053506 0.188766112100123 no 2724 0.196091845499808 3936 3848840
SGTC_1278 0874-0585 172 µM -0.855815812611667 0.188723071350939 no 2725 0.196049833669624 3965 766306
SGTC_2396 5342950 42.78 µM -0.857701606695801 0.188189136961815 no 2726 0.195528626312929 3915 1886677
SGTC_3289 9119912 71.43 µM -0.861996876437428 0.186976479667242 no 2727 0.194344618347009 3948 17014829
SGTC_3197 9113331 49.47 µM -0.862921498045956 0.186716070645828 no 2728 0.194090314928591 3916 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3226 9131256 49.47 µM -0.862925778977356 0.186714865493216 no 2729 0.19408913799375 3820 17178073
SGTC_966 1300-0360 30.2 µM -0.86424165241006 0.186344653720828 no 2730 0.193727577646645 3904 70588
SGTC_3159 9100096 49.47 µM -0.86469713119034 0.186216613979386 no 2731 0.193602522235281 3886 25236875
SGTC_2756 carbadox 75.1 µM -0.864875322563638 0.186166537403063 no 2732 0.19355361174195 3926 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_681 1642-0006 26.6 µM -0.865611801160647 0.185959655622193 no 2733 0.193351540882445 3934 4446530
SGTC_1350 1495-0454 146 µM -0.866067215310684 0.185831798087226 no 2734 0.193226651342969 3964 1069057
SGTC_3253 9135987 49.47 µM -0.866257368048428 0.185778428840089 no 2735 0.193174519782071 3900 4182430
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.866302684950511 0.185765711367847 no 2736 0.193162097137256 3944 1377
SGTC_149 3970-0822 46.1 µM -0.866666100262155 0.185663744136096 no 2737 0.193062492357437 3937 3114250 YBL034C STU1
SGTC_2622 2-methoxyxanthone 59.94 µM -0.868054853868696 0.185274407018863 no 2738 0.192682152092454 3940 71034 A hepatoprotective.
SGTC_2041 5107442 45.335 µM -0.868238535364637 0.18522294989363 no 2739 0.192631881242661 3949 793005
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.869187678071736 0.184957195446531 no 2740 0.192372242973383 3992 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_714 4296-0578 26.1 µM -0.869998486682129 0.184730361491578 no 2741 0.192150615609649 3962 1589775
SGTC_2432 5630864 12.22 µM -0.872108265768546 0.184140935076299 no 2742 0.191574658639939 3977 5714970
SGTC_2731 amoxapine 43.43 µM -0.872335225636783 0.184077597237262 no 2743 0.191512763027893 4010 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1121 fusaric acid 630.51 nM -0.87483861871685 0.183379873789735 no 2744 0.190830860537045 3923 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_227 fluconazole 33.516 µM -0.874861950621038 0.183373378693904 no 2745 0.190824512144369 3936 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_712 r015-0009 80.6 µM -0.875035578631699 0.183325048928584 no 2746 0.190777273658587 3972 6813872 YLR060W FRS1
SGTC_2188 6126565 140.678 µM -0.876272344611433 0.182981022027294 no 2747 0.190440997846531 3867 874518
SGTC_2166 5933061 31.504 µM -0.878254608893937 0.182430463359694 no 2748 0.189902781358908 4025 2877375
SGTC_808 0711-0032 135 µM -0.87831093206886 0.182414835165671 no 2749 0.189887502390979 3877 4252555
SGTC_1068 loratadine 26.9 µM -0.878662677395506 0.182317254047405 no 2750 0.189792100410072 3988 3957 A H1 histamine antagonist.
SGTC_840 0245-0196 390 µM -0.878866051473002 0.18226084893596 no 2751 0.189736953810176 4044 3827528
SGTC_27 0485-0001 32.618 µM -0.881289792697214 0.181589472183572 no 2752 0.189080494689686 3865 2054479
SGTC_3241 9133421 49.47 µM -0.881306972570678 0.181584718886406 no 2753 0.189075846598682 3946 17018221
SGTC_752 1896-0090 130 µM -0.882432621632925 0.181273445993694 no 2754 0.188771450631334 3919 772567
SGTC_1836 st055642 81 µM -0.886500508592495 0.180151351542386 no 2755 0.187673940108019 3963 8571
SGTC_2050 5263056 171 µM -0.887069975067195 0.179994617351335 no 2756 0.187520613959145 3984 763468 YGL055W OLE1
SGTC_534 k292-0788 63.4 µM -0.88931819935066 0.179376675507195 no 2757 0.186916046638117 3944 4146317
SGTC_3120 9124077 49.47 µM -0.890907401449187 0.178940676672233 no 2758 0.186489424631552 4033 18774327 YGL155W CDC43
SGTC_287 k060-0039 29.6 µM -0.891125671046052 0.178880846370018 no 2759 0.186430877200436 4012 5861974
SGTC_218 alverine citrate 93.75 µM -0.891356500451319 0.178817586974493 no 2760 0.186368973184076 3992 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1364 1653-0028 37.6 µM -0.895962094264701 0.177558356685857 no 2761 0.185136504238859 3965 5718652
SGTC_1080 nisoldipine 24.4 µM -0.897714597753049 0.177080672592881 no 2762 0.184668862474645 3958 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_719 2810-4230 27.3 µM -0.898742026882895 0.17680100163095 no 2763 0.184395042906685 3963 721079
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.898944998621306 0.176745784829816 no 2764 0.184340978914471 3908 279621
SGTC_2305 7443522 69.23 µM -0.900098801563481 0.176432109342803 no 2765 0.184033836876914 3880 5415886
SGTC_2954 9074818 52.69 µM -0.900614856866134 0.176291927426901 no 2766 0.183896566272802 3981 16648742
SGTC_483 fpl-64176 144 µM -0.900807356213337 0.176239654714076 no 2767 0.183845377819746 4006 3423
SGTC_1104 tacrolimus 29.8 µM -0.901510375233503 0.176048835006401 no 2768 0.183658509955376 3998 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1145 3546-0597 10.2 µM -0.901922531510753 0.175937024710061 no 2769 0.183549010697102 3955 875334
SGTC_1723 st034307 2.5525 µM -0.903608269221511 0.175480183795807 no 2770 0.183101577467785 4032 867466
SGTC_3334 9142812 21.919 µM -0.904309934581699 0.175290251806724 no 2771 0.182915540197862 4000 45283678
SGTC_1408 3909-7976 48.8 µM -0.904541354736252 0.175227637878151 no 2772 0.182854208089135 4023 24152374
SGTC_2906 7926292 26.41 µM -0.904937656347079 0.175120445934766 no 2773 0.18274920810028 3988 2966319
SGTC_1746 st038117 42 µM -0.906663505458199 0.174654122156319 no 2774 0.182292383941006 4050 2898218
SGTC_1744 st037937 38.9 µM -0.907687276025805 0.174377872653504 no 2775 0.182021734180136 4066 1016152
SGTC_3124 9127567 49.47 µM -0.908710992916829 0.174101915359454 no 2776 0.181751349977845 3981 17592030
SGTC_909 3448-9333 149 µM -0.909808678762846 0.173806327278895 no 2777 0.181461708405839 3908 3344074
SGTC_463 ikarugamyin 104 µM -0.91010380131052 0.173726910286566 no 2778 0.181383885020195 4042 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1248 0469-0687 58.6 µM -0.911135426670099 0.173449483015738 no 2779 0.181112011142178 3992 4017482
SGTC_1691 st019933 84.6 µM -0.912371021230191 0.173117575189409 no 2780 0.180786719531465 3929 6176082
SGTC_1719 st032227 49.2 µM -0.913589302250896 0.172790714510909 no 2781 0.180466344842651 3988 3125804
SGTC_3288 9119690 36.221 µM -0.913920423029614 0.172701943952501 no 2782 0.180379330697729 3989 17595618 YKL019W RAM2
SGTC_1753 st043925 64 µM -0.914105275158471 0.172652399375926 no 2783 0.180330765463764 4039 670181
SGTC_2260 7964312 200 µM -0.916111405916436 0.172115293598777 no 2784 0.179804233019662 4060 231951
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.918665346993055 0.171433066153661 no 2785 0.179135320243348 4014 2374 Ca(2+)-ATPase inhibitor.
SGTC_1525 8-methoxypsoralen 92.5 µM -0.922791924836094 0.170334402325499 no 2786 0.178057824920416 4066 4114 Related to psoralen; DNA damaging agent.
SGTC_270 tamoxifen 5.46 µM -0.923086599861594 0.170256120691324 no 2787 0.177981038626014 4003 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2176 5809774 33.9695 µM -0.925581219684807 0.169594338374025 no 2788 0.177331828481451 3973 2870539
SGTC_407 eburnamonine 100 µM -0.92587932970826 0.169515365135174 no 2789 0.17725434724319 3860 3195
SGTC_520 3584-0023 682 µM -0.926335353532796 0.169394604130741 no 2790 0.177135864287498 4011 1340790
SGTC_134 0269-0018 6.916 µM -0.927835985643067 0.168997607240633 no 2791 0.176746327137517 3966 4378915
SGTC_996 3970-0799 1.8 µM -0.930325418915895 0.168340339084404 no 2792 0.176101310366475 4027 6615648 YGL040C HEM2
SGTC_397 arbidol 50 µM -0.930401492662626 0.168320279772221 no 2793 0.176081623010355 4049 131410 A RNA synthesis inhibitor.
SGTC_1179 1021-1431 9.29 µM -0.931633741447624 0.167995571543635 no 2794 0.175762919697485 4045 2840958
SGTC_2802 7925815 54.55 µM -0.932616578692061 0.1677368746262 no 2795 0.175508985202327 3980 1262923
SGTC_2794 7785382 27.27 µM -0.932647552272633 0.167728726105438 no 2796 0.175500986376306 3943 2205081
SGTC_2013 4024628 200 µM -0.933034891122593 0.167626846637593 no 2797 0.17540097689598 4070 5230760
SGTC_1198 1612-1005 86.7 µM -0.937778244828462 0.166382463818721 no 2798 0.174179191724797 4103 6998509
SGTC_2938 9059746 27.26 µM -0.93907165938278 0.166044183978494 no 2799 0.173846976939031 4030 6471769
SGTC_1777 st045864 34.765 µM -0.940046624725834 0.165789485348109 no 2800 0.173596822696879 3989 4691462
SGTC_2284 7945075 39.21 µM -0.94076461437372 0.165602080273484 no 2801 0.173412749175479 4037 1245402
SGTC_1345 1488-0192 31.4 µM -0.941514336900721 0.165406538758778 no 2802 0.173220672838413 4057 658348
SGTC_2299 7976368 114.88 µM -0.945744624070713 0.16430600228065 no 2803 0.172139428042179 4067 2979718
SGTC_3182 9108849 49.47 µM -0.945979713868268 0.164244981728168 no 2804 0.172079466619288 4067 17133045
SGTC_3173 9105693 49.47 µM -0.948386621438843 0.163621083776984 no 2805 0.171466333849784 4043 17096658
SGTC_3291 9121177 71.43 µM -0.948413278737525 0.163614182527073 no 2806 0.171459551027924 4051 17015612
SGTC_81 0411-0046 9.971 µM -0.949381632405889 0.163363615691592 no 2807 0.171213274339704 3967 12925265
SGTC_1666 st014829 29 µM -0.949507434147058 0.163331082104593 no 2808 0.171181296402879 4016 3858230
SGTC_2105 5350118 200 µM -0.949966736587794 0.163212337644627 no 2809 0.171064577313126 4020 2133313
SGTC_378 3970-0959 8.33 µM -0.950738037956883 0.163013057653787 no 2810 0.170868686816509 4060 6615653
SGTC_1326 1431-2094 10.8 µM -0.951381908757419 0.162846822893399 no 2811 0.170705270339738 4022 616278
SGTC_1481 3346-2004 36 µM -0.951891922570284 0.162715225640098 no 2812 0.170575898224571 4069 2770522
SGTC_132 0417-1715 25.805 µM -0.95340352925995 0.162325596981411 no 2813 0.170192826971906 3988 6769098
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.955137313837391 0.161879448612833 no 2814 0.169754130681596 3948 5355888
SGTC_1420 4'-methoxyflavone 42 µM -0.956278259401586 0.161586289586316 no 2815 0.169465835348957 4024 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2421 5690543 90.72 µM -0.960376904026573 0.160536024432546 no 2816 0.16843277886051 4061 3397993
SGTC_1291 0993-0025 5.79 µM -0.961335076926513 0.160291140114162 no 2817 0.1681918582196 4052 4353356
SGTC_2336 9001819 198.65 µM -0.963367687699433 0.159772465861484 no 2818 0.167681517947561 4112 2989602
SGTC_2106 5357045 167.29 µM -0.964194215489147 0.159561869876012 no 2819 0.167474281967654 4079 668842
SGTC_870 0573-2213 57.6 µM -0.964671116058169 0.159440440208268 no 2820 0.167354783410031 4038 3916321
SGTC_2365 9042475 200 µM -0.965166249828203 0.159314431984008 no 2821 0.167230774253943 4125 6464479
SGTC_1738 st035555 74 µM -0.965707940507372 0.159176650057152 no 2822 0.167095172513644 4118 5331140
SGTC_233 rapamycin 362 pM -0.966530360372029 0.158967612408449 no 2823 0.166889431243875 4037 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_717 1532-0246 73.2 µM -0.970018041670391 0.158083134774951 no 2824 0.166018749619716 4044 9561992
SGTC_871 0574-0004 149 µM -0.970498236701443 0.157961610570658 no 2825 0.16589910170644 4035 9551173
SGTC_1401 3807-4679 7.6 µM -0.970517608588903 0.157956709364233 no 2826 0.165894276075128 3986 3291456
SGTC_3276 9139060 49.47 µM -0.971641571150655 0.157672510898055 no 2827 0.165614446879698 4136 4870619
SGTC_481 bay k-8644 50 µM -0.972344367487814 0.157494976806737 no 2828 0.165439629227372 4015 2303 A calcium channel antagonist.
SGTC_1180 1193-0155 285 µM -0.972941922810252 0.157344131126578 no 2829 0.165291083774484 4139 2921347
SGTC_2786 7743617 45.45 µM -0.976946817278279 0.156335595598926 no 2830 0.164297741114051 4013 583674
SGTC_1404 3909-7820 48.3 µM -0.977537974091956 0.156187088530749 no 2831 0.164151443728916 4035 23741373
SGTC_1983 st071813 46.9 µM -0.97914923120772 0.155782789691899 no 2832 0.163753124673751 4115 11838595
SGTC_603 3794-0023 45.9 µM -0.980342089401618 0.155483921020745 no 2833 0.163458642569446 4112 3802260
SGTC_1937 st074714 47.2 µM -0.980799385804171 0.155369446529307 no 2834 0.163345840606078 4028 17250970
SGTC_2453 5731132 22.18 µM -0.981802510387113 0.155118530347628 no 2835 0.163098575595091 4114 1362040
SGTC_2034 5197015 53.07 µM -0.982229871421353 0.155011713873182 no 2836 0.16299330725223 4080 780676
SGTC_1979 st071809 45.3 µM -0.982349607933555 0.154981795121897 no 2837 0.162963821460902 4161 4976333
SGTC_70 0141-0289 43.283 µM -0.98358904988255 0.154672317869582 no 2838 0.162658805645203 4060 352408
SGTC_863 0466-0191 129 µM -0.985747654625358 0.154134309683238 no 2839 0.16212847911133 4110 765160 YPR165W RHO1
SGTC_2198 6589944 200 µM -0.985816477960878 0.154117176621422 no 2840 0.162111589120428 4072 5290268
SGTC_1492 4158-0558 28.5 µM -0.986877380104554 0.153853232247474 no 2841 0.161851377236478 4055 3967268
SGTC_2413 inermin 26.06 µM -0.98930335102726 0.153250794059952 no 2842 0.161257372508159 4186 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1725 st036284 20.55 µM -0.99438529138669 0.151993875683054 no 2843 0.160017663080358 4174 707914
SGTC_509 pifithrin 175 µM -0.995233178882561 0.151784835750395 no 2844 0.15981143418048 4135 4817 A p53 inhibitor.
SGTC_1293 1000-1278 195 µM -0.997955550826629 0.151114948513525 no 2845 0.159150456470108 4145 678847
SGTC_2793 7325131 81.82 µM -0.998870171793771 0.150890332150417 no 2846 0.158928793720307 4060 4176441
SGTC_2256 7954252 200 µM -1.00009536280631 0.150589793136481 no 2847 0.15863218002437 4108 2972920
SGTC_1685 st024049 53.0905 µM -1.00079904133891 0.150417361358321 no 2848 0.15846198656492 4110 1941139
SGTC_688 0527-0193 473 µM -1.00112016080426 0.150338716882538 no 2849 0.158384359617661 4131 4007154
SGTC_1182 1222-0449 220 µM -1.00325791891419 0.149815862920247 no 2850 0.157868217072044 4090 658318
SGTC_797 k781-0471 270 µM -1.00537099096658 0.149300240038882 no 2851 0.157359121469681 4064 23738129
SGTC_821 1114-0266 29.2 µM -1.00975299667964 0.148234741988491 no 2852 0.156306822318461 4129 3123235
SGTC_775 4577-0580 57.3 µM -1.01163041149953 0.147779803377026 no 2853 0.155857399729451 4161 2006902
SGTC_1456 k015-0012 13 µM -1.01292339415958 0.147467029673075 no 2854 0.155548376585824 4097 2989616
SGTC_1710 st031758 61.5 µM -1.01354975679418 0.147315671560656 no 2855 0.155398821202662 4131 5394341
SGTC_482 fipronil 114 µM -1.01417529305878 0.147164617084166 no 2856 0.155249557857555 4187 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_123 0083-0120 66.675 µM -1.01507893247862 0.146946589671876 no 2857 0.15503410162585 4071 16001701
SGTC_186 3455-3465 67.277 µM -1.015514955632 0.146841464835332 no 2858 0.154930210563706 4055 755278
SGTC_669 0108-0021 26.2 µM -1.01632824427673 0.146645516426376 no 2859 0.154736551501411 4008 17201
SGTC_1617 st002906 78 µM -1.01663241710464 0.146572276134118 no 2860 0.154664163439989 4097 5150859
SGTC_168 3970-0862 530.542 µM -1.01769396825747 0.146316862781238 no 2861 0.154411707318501 4078 3135186
SGTC_623 k072-0108 16.9 µM -1.02013213347954 0.145731362791858 no 2862 0.153832899414277 4074 5382803
SGTC_993 3909-8757 62.7 µM -1.02116089371662 0.145484789851635 no 2863 0.153589108361168 4050 4288324 YLR208W SEC13
SGTC_1302 1159-0335 255 µM -1.02267386123285 0.145122672279552 no 2864 0.15323103705292 4123 649284
SGTC_1084 voriconazole 435 nM -1.02286205061458 0.145077672998984 no 2865 0.153186537322711 4114 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_698 k064-0052 127 µM -1.02295340886442 0.14505583107482 no 2866 0.153164937611515 4199 5088751
SGTC_71 0417-1750 47.813 µM -1.02340006269621 0.144949076971362 no 2867 0.153059364889893 4127 6811472
SGTC_499 genistein 192 µM -1.02422144498346 0.144752897647748 no 2868 0.152865345931979 4177 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_638 3970-0837 4.09 µM -1.02434881028989 0.144722493680543 no 2869 0.15283527554574 4083 4118451 YLR208W SEC13
SGTC_280 3448-3607 3.04 µM -1.02478998166226 0.144617212854937 no 2870 0.15273114726132 4090 626179
SGTC_1235 benzylparaben 21.5 µM -1.02708022201107 0.144071500763809 no 2871 0.1521913454217 4131 7180
SGTC_2426 5582046 32.21 µM -1.02738086432816 0.143999967793242 no 2872 0.152120579226666 4131 2251934
SGTC_1254 0550-0035 264 µM -1.02951377490614 0.143493164108344 no 2873 0.151619155087753 4181 15121435
SGTC_3195 9113082 49.47 µM -1.03074351741773 0.143201511278793 no 2874 0.151330555839045 4101 17018038
SGTC_1393 3470-5649 58.2 µM -1.0317052921743 0.142973690446522 no 2875 0.151105098746205 4092 4108395
SGTC_447 ml7 120 µM -1.03177816498333 0.142956438653888 no 2876 0.151088025177993 4143 4216 Selective myosin light chain kinase inhibitor.
SGTC_284 0988-0104 32.6 µM -1.03232590948463 0.142826811518739 no 2877 0.150959733718392 4114 4666532
SGTC_1831 st055328 12 µM -1.03304488143476 0.142656782964142 no 2878 0.150791447829982 4125 1103068
SGTC_3341 9147222 25.867 µM -1.03415479888323 0.142394569134129 no 2879 0.150531900759238 4131 1939759
SGTC_1676 st018489 23.4 µM -1.03430935395175 0.142358081957343 no 2880 0.150495782666044 4153 3696235
SGTC_709 3807-1509 243 µM -1.03759601007086 0.141583669385012 no 2881 0.149729088125526 4190 1886677 YPL242C IQG1
SGTC_1854 st056233 32.9 µM -1.03867661032455 0.141329679475977 no 2882 0.149477581350542 4052 5393174
SGTC_1268 0828-0275 2.46 µM -1.0388089426459 0.141298596638203 no 2883 0.149446800753241 4180 745337
SGTC_2878 9043973 25.97 µM -1.03909953175213 0.141230357964137 no 2884 0.149379224355457 4181 6465167
SGTC_2194 5927483 104.545 µM -1.03954369681483 0.141126098421778 no 2885 0.149275973345375 4163 760979
SGTC_1391 3442-0225 151 µM -1.0396340802683 0.141104888968238 no 2886 0.149254968562831 4107 5227075
SGTC_3217 9129673 49.47 µM -1.04241613013973 0.140453108032423 no 2887 0.14860939565112 4175 17248312
SGTC_1245 0418-0076 17.2 µM -1.0427443210934 0.140376354192187 no 2888 0.148533362433516 4183 6790114
SGTC_2479 5617353 43.85 µM -1.04490249307338 0.139872333202621 no 2889 0.148034018717448 4182 2731746
SGTC_2741 miltefosine 3.04 µM -1.04618432554069 0.139573556084009 no 2890 0.147737969146116 4128 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_711 k292-0785 179 µM -1.04874600329239 0.138977766205252 no 2891 0.147147517614158 4074 4146315
SGTC_2097 5376186 200 µM -1.04974557835721 0.138745757348204 no 2892 0.146917551180028 4115 742755
SGTC_2154 5570129 200 µM -1.05003364708104 0.138678943436519 no 2893 0.146851321649513 4180 673366
SGTC_2414 st077232 92.9 µM -1.05058797384858 0.138550436000092 no 2894 0.146723933411601 4085 729801
SGTC_3143 9086658 49.47 µM -1.0525458681409 0.138097194448383 no 2895 0.14627458892555 4194 25236626
SGTC_543 3844-1095 191 µM -1.05310327577572 0.137968342818971 no 2896 0.146146830843625 4145 4230703
SGTC_689 0833-0039 98 µM -1.05400062118142 0.137761082712928 no 2897 0.145941316368087 4097 5374726
SGTC_2261 9010538 184.68 µM -1.05541138405746 0.137435668192176 no 2898 0.145618609305729 4158 6457250
SGTC_470 aa-861 153 µM -1.05677793696897 0.137120952191084 no 2899 0.145306472917245 4127 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1040 k898-0338 155 µM -1.06001265770042 0.136377961892551 no 2900 0.144569420440762 4169 20969351
SGTC_276 colchicine 750 µM -1.06053854957856 0.136257429374905 no 2901 0.144449830954861 4217 2833 A microtubule depolymerizer.
SGTC_2458 5808907 16.39 µM -1.06218566631189 0.13588038795668 no 2902 0.144075702828347 4298 2731747
SGTC_2653 dihydrofissinolide 100 µM -1.06292478394393 0.135711429006947 no 2903 0.143908031320961 4186 6857746
SGTC_117 lucigenin 22.078 µM -1.06674345475349 0.134840790891952 no 2904 0.143043849331384 4162 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2449 5812982 45.77 µM -1.06843580618441 0.134456171206617 no 2905 0.142661986335781 4092 776185
SGTC_1445 4239-0156 97.7 µM -1.06850067688716 0.134441443085634 no 2906 0.142647362608359 4241 4008346
SGTC_823 0417-1665 178 µM -1.07070922474714 0.133940679284148 no 2907 0.142150096843024 4158 3429856
SGTC_2345 9052315 157.45 µM -1.07198609722882 0.133651748053162 no 2908 0.141863138354848 4220 6469265
SGTC_1073 triclabendazole 3.09 µM -1.07202087753459 0.133643883951281 no 2909 0.141855327479572 4218 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2478 5763493 32.33 µM -1.07256027638867 0.133521962338117 no 2910 0.14173422789572 4091 1365576 YLR208W SEC13
SGTC_748 act1.228 77.9 µM -1.07313547733828 0.133392032595083 no 2911 0.141605167607881 4110 4421505 YNR035C ARC35
SGTC_3268 9137683 49.47 µM -1.07334907183767 0.133343806776938 no 2912 0.141557262778 4220 1953228
SGTC_1319 1306-0155 43.7 µM -1.0741574649135 0.133161394690273 no 2913 0.141376056353098 4220 3122360
SGTC_1903 st060211 78.3 µM -1.07692744628936 0.132537657326116 no 2914 0.140756340168989 4202 688960
SGTC_1683 st010134 710 nM -1.07822022808667 0.132247242055274 no 2915 0.140467743415145 4156 3818134
SGTC_2020 4017018 200 µM -1.07839953098362 0.132206997457926 no 2916 0.14042774811678 4219 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2002 4023503 131 µM -1.07962660457446 0.13193180697297 no 2917 0.140154244650372 4178 4736863 YCR052W RSC6
SGTC_1434 4073-0095 163 µM -1.08060131386801 0.131713494892263 no 2918 0.139937248924476 4122 24133745
SGTC_2540 epiandrosterone 100 µM -1.08093258466138 0.131639354771833 no 2919 0.139863551414254 4213 441302 A steroid.
SGTC_1942 st076330 65.2 µM -1.08240163902349 0.131310919872957 no 2920 0.139537050158978 4251 24208414
SGTC_2388 9080168 200 µM -1.08354565124526 0.131055546507691 no 2921 0.139283149680445 4164 15943073
SGTC_2722 naftopidil 47.16 µM -1.08570524541272 0.130574404461724 no 2922 0.138804709629775 4103 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_553 k007-0256 45.7 µM -1.08710118169318 0.130264050597889 no 2923 0.138496047839337 4232 6287000
SGTC_2992 9074591 71.4286 µM -1.08822699688996 0.130014123914265 no 2924 0.138247454704728 4140 17741321
SGTC_2728 chlorpromazine 9.18 µM -1.09039333324485 0.129534139783476 no 2925 0.137769958653874 4239 2726 A thorazine and dopamine antagonist.
SGTC_1508 1080-0625 72.9 µM -1.09072698099016 0.129460324385351 no 2926 0.137696517348473 4078 767111
SGTC_848 0368-0089 85.6 µM -1.09191972940632 0.129196682043077 no 2927 0.137434192487825 4187 762535
SGTC_1951 sophoraflavanone G 9.2 µM -1.09447983191457 0.128632060321009 no 2928 0.136872293993326 4147 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1348 1493-0373 93.8 µM -1.09539057876126 0.128431611799438 no 2929 0.136672779896368 4189 3010129
SGTC_2868 9035608 32.47 µM -1.09563548384601 0.128377747048461 no 2930 0.136619163346171 4160 6462614
SGTC_1292 0kpi-0043 232 µM -1.09648199698576 0.128191684624615 no 2931 0.136433948808649 4212 3333905
SGTC_1333 1482-0047 286 µM -1.09649969641018 0.128187796315321 no 2932 0.136430078061698 4204 3811116
SGTC_1851 st056236 18.9 µM -1.09667248959154 0.128149840438654 no 2933 0.136392293283315 4198 5393171
SGTC_1438 4092-1045 4 µM -1.09867228078323 0.12771113271926 no 2934 0.135955518707025 4207 1351342
SGTC_772 k072-0172 35.3 µM -1.10034109207335 0.127345834228132 no 2935 0.135591767235494 4234 5861980
SGTC_2272 7805186 180 µM -1.10148157516024 0.127096603866105 no 2936 0.135343559557227 4201 2956062 YPR165W RHO1
SGTC_2734 clemastine 41.6 µM -1.10259754886651 0.126853058311886 no 2937 0.135100987584335 4253 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3328 9140624 29.0385 µM -1.10350109379374 0.126656110508909 no 2938 0.134904808408102 4206 4904392
SGTC_751 0833-0568 350 µM -1.1038441879803 0.126581381278226 no 2939 0.134830366443395 4216 6954252
SGTC_2006 4011487 200 µM -1.10970299203131 0.125310015377466 no 2940 0.133563516582465 4220 45595294
SGTC_1238 0333-0287 48.8 µM -1.11144881068783 0.124932901057506 no 2941 0.133187606132944 4173 7226
SGTC_3349 9149703 23.001 µM -1.11256382485045 0.124692462126293 no 2942 0.132947902130414 4217 4910494
SGTC_448 monastrol 171 µM -1.1137545474639 0.124436054910517 no 2943 0.132692250567739 4126 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2732 terfenadine 20 µM -1.11440988164915 0.124295094289679 no 2944 0.13255169299254 4263 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2264 7948757 110.76 µM -1.11668202944738 0.123807226451024 no 2945 0.132065152096584 4171 2971411
SGTC_88 0180-0332 8.668 µM -1.11763500303304 0.123603006750066 no 2946 0.131861456422315 4288 3101745
SGTC_3016 9080866 49.47 µM -1.11984030760909 0.123131320782193 no 2947 0.13139090960707 4185 17066299
SGTC_275 trichlorophene 5.69 µM -1.12208028548542 0.122653511639315 no 2948 0.130914152669881 4252 62616
SGTC_2570 licareol 100 µM -1.12368133728519 0.122312789717652 no 2949 0.130574118230942 4205 443158
SGTC_1706 st031321 9.9705 µM -1.12536314638775 0.121955597797524 no 2950 0.130217590614777 4239 6103185
SGTC_703 3875-0075 71.8 µM -1.12799304895076 0.121398514282348 no 2951 0.129661427372291 4273 2850814
SGTC_1344 1488-0097 29.1 µM -1.12814818212335 0.121365708910997 no 2952 0.129628671778959 4259 747966
SGTC_2367 9070478 135.38 µM -1.13019437485695 0.120933592218771 no 2953 0.129197164763386 4164 572802
SGTC_2926 9010726 65.15 µM -1.13164509712158 0.120627884088183 no 2954 0.12889183615793 4247 2994293
SGTC_155 k072-0202 43.6 µM -1.13186244051763 0.120582130604733 no 2955 0.128846135771953 4203 5857737
SGTC_187 1488-2104 32.728 µM -1.13313998336247 0.120313438975948 no 2956 0.128577736458265 4242 2852859
SGTC_1059 3448-6867 171 µM -1.13363758755673 0.120208897541481 no 2957 0.128473299734836 4183 3934407
SGTC_2870 9038528 12.99 µM -1.13403613693004 0.120125212660463 no 2958 0.128389695026188 4267 6463316
SGTC_2103 5378138 10 µM -1.13498585940741 0.119925961431203 no 2959 0.128190621608869 4291 244142
SGTC_2087 5276107 200 µM -1.13564609764013 0.119787581183899 no 2960 0.128052353998202 4188 144405
SGTC_2568 diosmetin 100 µM -1.1358409541345 0.119746762466979 no 2961 0.128011566804581 4274 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3057 9095946 49.47 µM -1.13703555748621 0.119496730252719 no 2962 0.127761710738722 4270 24540043
SGTC_95 0471-0001 561.058 µM -1.14255203094264 0.118346902324169 no 2963 0.126612315770938 4226 4015405
SGTC_532 1548-0774 215 µM -1.14324021609291 0.118204010832879 no 2964 0.126469434556935 4349 5932993
SGTC_34 0469-0683 81.75 µM -1.14796958220301 0.117225327335681 no 2965 0.12549056056505 4205 3690923
SGTC_2534 helenine 20.12 µM -1.14837792675746 0.117141095497809 no 2966 0.125406290955371 4248 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2443 5493264 126.67 µM -1.14932559986049 0.116945778172044 no 2967 0.125210872945133 4279 5340055
SGTC_2683 piperine 63.03 µM -1.15520763904751 0.115738639575778 no 2968 0.124002703618936 4223 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_431 k089-0097 107 µM -1.15545463851273 0.115688143566519 no 2969 0.123952149085735 4036 5499420
SGTC_889 0919-1524 82.7 µM -1.15682762024526 0.115407739552715 no 2970 0.123671397444747 4266 3905452
SGTC_742 0kpi-0133 140 µM -1.15716541149269 0.115338826551825 no 2971 0.123602393126007 4277 2728852
SGTC_2337 9009472 200 µM -1.16030423408992 0.114699871712775 no 2972 0.122962480623461 4227 5742383
SGTC_790 1575-0012 79.1 µM -1.16041637490911 0.114677090445028 no 2973 0.12293966150201 4308 378741 YLR208W SEC13
SGTC_2830 7992007 71.43 µM -1.16049862708064 0.114660383065827 no 2974 0.122922926198815 4131 1952075
SGTC_2624 nerol 100 µM -1.1605869210385 0.11464245038335 no 2975 0.122904963391148 4154 637566 A natural product oil.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.16194385675555 0.114367104984331 no 2976 0.122629135488762 4246 140250 A respiratory chain inhibitor.
SGTC_932 2857-0803 154 µM -1.16320893229456 0.11411082399204 no 2977 0.12237237167039 4292 674898
SGTC_299 1273-0059 1.44 µM -1.16531246878777 0.113685592342232 no 2978 0.121946266883511 4073 2848077
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.16717583573114 0.113309855698196 no 2979 0.121569683639489 4344 688664
SGTC_2409 alverine citrate 63.97 µM -1.16845870945704 0.113051687385325 no 2980 0.121310892625687 4353 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1796 st049173 110.4 µM -1.16914234099718 0.112914283456539 no 2981 0.121173143620173 4220 94134
SGTC_2152 5568786 200 µM -1.16923881678158 0.112894902274834 no 2982 0.121153712999634 4255 5399883
SGTC_3251 9135047 49.47 µM -1.17153600679287 0.112434117225892 no 2983 0.120691696722643 4285 17682963
SGTC_190 3970-0790 3.722 µM -1.17546945371882 0.111648244311824 no 2984 0.119903475506354 4226 2832352
SGTC_2438 5259590 200 µM -1.17622495920506 0.111497751022345 no 2985 0.119752496591121 4280 1201127
SGTC_2798 7813637 45.45 µM -1.18053223102821 0.110642534549236 no 2986 0.118894299566572 4257 956368
SGTC_2183 6420625 130.508 µM -1.18062774948542 0.110623622622674 no 2987 0.118875317466982 4281 2897619
SGTC_1952 st077036 64.1 µM -1.18196380279867 0.110359337065078 no 2988 0.118610031888794 4284 2937007
SGTC_1325 1431-0015 227 µM -1.1831328184324 0.110128464975034 no 2989 0.118378256541713 4280 1103340
SGTC_1027 k015-0025 8.67 µM -1.18361241024235 0.110033849374733 no 2990 0.118283262758973 4251 3598955
SGTC_1200 1643-0193 18.4 µM -1.18652259408826 0.109460968370675 no 2991 0.117707992093496 4293 5403974
SGTC_3250 9135583 49.47 µM -1.18671712561062 0.10942275060807 no 2992 0.117669608798447 4311 7699353
SGTC_301 4119-0100 24.5 µM -1.19008252593837 0.108763098876865 no 2993 0.117006978780876 4298 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1257 0669-0121 16 µM -1.19027397003263 0.108725660089771 no 2994 0.116969364072036 4270 4307855
SGTC_2565 isoliquiritigenin 100 µM -1.19312450360434 0.108169306037937 no 2995 0.11641030812773 4358 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2383 9036125 200 µM -1.19349643286629 0.10809686600269 no 2996 0.116337504177686 4199 79580
SGTC_296 1222-0039 74.9 µM -1.19474526694017 0.107853888225171 no 2997 0.116093285303999 4283 5984176
SGTC_396 dithiazanine 1.25 µM -1.19640407642616 0.107531752726449 no 2998 0.115769455667192 4260 10578 An antihelmenthic.
SGTC_2676 harmalol 100 µM -1.19719518041931 0.107378367284702 no 2999 0.115615243982821 4239 5459187 A monoamine oxidase inhibitor
SGTC_1960 st011366 51.8 µM -1.19830495855422 0.107163460702434 no 3000 0.115399158459528 4294 3972846
SGTC_2733 amorolfine 100 µM -1.19898567200088 0.107031795306661 no 3001 0.11526675846347 4424 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_273 hydroxyurea 18.1 mM -1.19985231631906 0.106864335562465 no 3002 0.115098350874315 4349 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1205 4161-2785 76 µM -1.20685218035421 0.105518693420486 no 3003 0.113744538233861 4330 3498106
SGTC_2213 7173844 200 µM -1.20946098808788 0.105020328362352 no 3004 0.113242895078982 4284 892728
SGTC_121 0557-0495 61.343 µM -1.20947607833215 0.105017450611448 no 3005 0.113239998000351 4370 3104427
SGTC_3221 9128209 49.47 µM -1.20980219821136 0.104955272602986 no 3006 0.113177401267376 4320 16460723
SGTC_986 1493-0483 84 µM -1.20988447775933 0.104939589397303 no 3007 0.11316161210804 4233 40079
SGTC_2187 6125751 200 µM -1.20999237659509 0.10491902550126 no 3008 0.113140909078369 4293 874498
SGTC_438 sphingosine 6.67 µM -1.21158198511504 0.104616408039499 no 3009 0.112836216975408 4222 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1756 st041558 35.5 µM -1.21333263122034 0.104283865604259 no 3010 0.112501335934646 4382 3955792
SGTC_3020 9089140 49.47 µM -1.21657831158689 0.103669363417891 no 3011 0.111882349380649 4316 17217859
SGTC_1665 st014639 11.4 µM -1.21752240871377 0.103491112465764 no 3012 0.111702757895511 4364 981133 YIL048W NEO1
SGTC_3006 9075424 71.4286 µM -1.21890083153 0.10323125797664 no 3013 0.111440917021752 4257 7465181
SGTC_1630 st005209 31.3 µM -1.21924750731763 0.10316597873485 no 3014 0.111375132763886 4291 3367314
SGTC_2035 5154463 94.595 µM -1.22028292650489 0.102971187214634 no 3015 0.111178819919428 4318 2769623
SGTC_1829 berberine 14.4 µM -1.22206686638275 0.102636204833129 no 3016 0.110841170856782 4257 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2655 perillic acid 100 µM -1.22221401588835 0.102608608986234 no 3017 0.110813352476786 4327 5702197 An apoptosis inducer.
SGTC_1941 st076221 61.8 µM -1.22237694718796 0.102578059775558 no 3018 0.110782556409927 4182 2828568
SGTC_1091 telmisartan 47.6 µM -1.22374228809039 0.102322321593808 no 3019 0.110524730777543 4337 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1374 2889-5571 141 µM -1.2238142991389 0.102308846290622 no 3020 0.110511144444423 4338 2853281
SGTC_409 arachidonic acid 100 µM -1.22612789812446 0.101876593141509 no 3021 0.110075274426144 4294 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.2272674095013 0.101664185757007 no 3022 0.109861050305468 4331 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2775 cyproheptadine 69.59 µM -1.22788953031736 0.101548357258259 no 3023 0.109744220136035 4313 2913 A selective serotonin reuptake inhibitor.
SGTC_526 4469-0568 170 µM -1.22923657254117 0.101297889901055 no 3024 0.109491560204072 4273 2901964
SGTC_1439 4092-1168 46 µM -1.23030845652837 0.101098906931554 no 3025 0.109290809394121 4310 2886240
SGTC_459 nigericin 15.3 µM -1.23423591440281 0.10037225373064 no 3026 0.108557504129247 4384 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1432 4049-0298 68.4 µM -1.2353545430841 0.100165985582048 no 3027 0.108349291317908 4336 741646
SGTC_545 4218-0007 221 µM -1.2372527189699 0.09981668214883 no 3028 0.107996637511973 4299 2840508
SGTC_1785 bathophenanthroline 24 µM -1.23818971701422 0.0996445836088237 no 3029 0.107822861744651 4238 72812 An iron chelator.
SGTC_1312 1218-2183 165 µM -1.24005785533269 0.0993021096733146 no 3030 0.107476997850465 4381 6744073
SGTC_3042 9091578 49.47 µM -1.24250633522633 0.0988545495990684 no 3031 0.107024902259796 4320 25236497
SGTC_170 4197-0004 226 µM -1.2443515334124 0.0985182405476724 no 3032 0.106685106151739 4318 218692
SGTC_1587 estradiol valerate 56.1 µM -1.25056929441871 0.0973911483853945 no 3033 0.105545829556215 4379 13791 A steroid.
SGTC_2694 st077685 81.9 µM -1.25059193147198 0.0973870623257512 no 3034 0.105541697919525 4246 2838096
SGTC_2736 butenafine 14.65 µM -1.2518930273098 0.0971524217053791 no 3035 0.105304422926622 4269 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3146 9095609 49.47 µM -1.25211846594521 0.0971118081356222 no 3036 0.105263349955497 4370 17173999
SGTC_531 3788-1495 174 µM -1.25216620625197 0.0971032091490415 no 3037 0.105254653571571 4309 2896655
SGTC_484 loperamide 105 µM -1.25526108793657 0.0965469506432047 no 3038 0.104691997983407 4398 3955 An opioid-receptor agonist.
SGTC_768 0384-0033 77.3 µM -1.25646511643728 0.0963311783145587 no 3039 0.104473692859919 4290 3965305 YMR134W ERG29
SGTC_1802 st050112 57.9 µM -1.25698973466862 0.0962372731187122 no 3040 0.104378676376898 4323 4662563
SGTC_2962 9082311 13.18 µM -1.26217177812575 0.0953133144938231 no 3041 0.103443490760882 4305 16459453
SGTC_1239 0337-0584 35.4 µM -1.26343211130619 0.0950895876320081 no 3042 0.103216965033696 4409 914301 YML130C ERO1
SGTC_200 k038-0079 37.545 µM -1.2643158595829 0.0949329407396388 no 3043 0.103058339700283 4312 3436683
SGTC_1904 st060225 78 µM -1.26564160629844 0.0946983050101469 no 3044 0.102820711551464 4292 66595
SGTC_1807 st050092 58.9 µM -1.26595506458938 0.0946428904906725 no 3045 0.102764585220267 4351 5008496
SGTC_430 0958-0115 16.4 µM -1.26642492189987 0.0945598718433493 no 3046 0.102680496538544 4279 6833180
SGTC_1477 0139-0234 16 µM -1.26685342118544 0.094484207522121 no 3047 0.102603853165307 4337 620880
SGTC_2572 astragaloside iv 100 µM -1.27048549255316 0.0938446491162073 no 3048 0.101955873642232 4362 45006101 An anti-inflammatory agent.
SGTC_488 nitrendipine 139 µM -1.2704895791705 0.0938439313225899 no 3049 0.1019551462506 4376 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2064 5220758 200 µM -1.27055299987537 0.0938327923167497 no 3050 0.101943858256671 4394 788518
SGTC_3326 9140064 16.379 µM -1.27183940568104 0.0936070628130992 no 3051 0.101715092398335 4293 1868434
SGTC_2427 5545055 42.75 µM -1.27789379185036 0.0925500643870547 no 3052 0.100643438670373 4273 5372858
SGTC_3324 9138759 60.749 µM -1.28058404732463 0.0920832327464426 no 3053 0.100169903118971 4381 45595710
SGTC_942 3253-1115 227 µM -1.28314082695398 0.0916411807320191 no 3054 0.0997213712317735 4373 46497897
SGTC_1055 3448-0672 86 µM -1.28704681608314 0.090968897281744 no 3055 0.0990389854610157 4328 748378
SGTC_2243 6634756 200 µM -1.29231950299038 0.0900671953325768 no 3056 0.0981232603062116 4409 885676
SGTC_1905 st060207 84.5 µM -1.29382177781623 0.0898115053050682 no 3057 0.0978634942406099 4346 1948547
SGTC_1936 st074407 74.3 µM -1.29393950644585 0.0897914904903648 no 3058 0.0978431584964011 4384 809813
SGTC_1833 st055984 71 µM -1.29661403353071 0.089337692169729 no 3059 0.0973820107114511 4370 676288
SGTC_1546 5-methoxyflavanone 78.7 µM -1.29690121024826 0.0892890672992353 no 3060 0.0973325900259687 4379 147795
SGTC_2470 5664817 21.68 µM -1.29845632076025 0.0890260973660849 no 3061 0.0970652882312447 4402 2859561
SGTC_195 4234-0266 16.654 µM -1.2992122967882 0.0888984698834898 no 3062 0.0969355413001988 4377 2303354
SGTC_1466 k213-0079 57.5 µM -1.29979187699106 0.0888007146728839 no 3063 0.0968361551576629 4309 3657981
SGTC_61 0978-8327 98.565 µM -1.30036864346532 0.0887035135244697 no 3064 0.0967373258106259 4278 6150059 YHR072W ERG7
SGTC_77 0828-0286 12.516 µM -1.30271469065903 0.0883089560866854 no 3065 0.0963360923651997 4264 745345
SGTC_2778 tioconazole 65.09 nM -1.30346906037557 0.0881823647478246 no 3066 0.0962073362733972 4257 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.30393670342518 0.0881039571715226 no 3067 0.0961275823320737 4369 616764
SGTC_3230 9131665 49.47 µM -1.3049575102274 0.087932983729602 no 3068 0.095953658240938 4356 15943720
SGTC_2386 9075165 157.42 µM -1.30809479271607 0.0874090736781752 no 3069 0.0954205797268913 4360 16452277
SGTC_2107 5363541 170.161 µM -1.31370678432062 0.0864777172445481 no 3070 0.0944724485014125 4325 244052
SGTC_854 0422-0053 192 µM -1.31463221056226 0.086324850367594 no 3071 0.0943167696575736 4389 3596728
SGTC_1087 pterostilbene 9.05 µM -1.31562681190766 0.0861607821768556 no 3072 0.0941496649378354 4376 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2594 a-mangostin 100 µM -1.31622547178175 0.0860621405137351 no 3073 0.0940491883959406 4392 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1618 st003135 44.5 µM -1.3163337738372 0.0860443045267685 no 3074 0.0940310198913597 4342 1270615
SGTC_2981 9013952 38.96 µM -1.31679670712731 0.0859680964095716 no 3075 0.09395338845763 4335 2996344
SGTC_1885 st057546 99.9 µM -1.31813805059158 0.0857475695306663 no 3076 0.0937287194255493 4418 702008
SGTC_2892 9047358 58.44 µM -1.32182607278625 0.0851434142581465 no 3077 0.0931130370732686 4377 6466771
SGTC_1611 st001856 99.4 µM -1.32434738825627 0.0847322231885972 no 3078 0.0926938495063174 4352 647478
SGTC_1125 tnp00248 1.32998 µM -1.32458901572946 0.0846928954775465 no 3079 0.0926537505369369 4419 24207736
SGTC_3278 9139605 49.47 µM -1.33033038237033 0.0837624431534464 no 3080 0.0917047205097328 4372 7958859
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.3372630117866 0.082649192337447 no 3081 0.0905684000462829 4382 75037 A free radical scavenger.
SGTC_998 3996-0085 177 µM -1.33986046327509 0.0822349702039827 no 3082 0.0901453569851034 4414 715391
SGTC_3025 9087895 49.47 µM -1.34111270350165 0.0820358317751711 no 3083 0.089941931700377 4362 17173641
SGTC_2735 sertaconazole 140 nM -1.34582938828708 0.0812890182971064 no 3084 0.0891787726655352 4546 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_816 0325-0417 81.3 µM -1.34809838508904 0.0809315903057623 no 3085 0.0888133703938947 4433 68101
SGTC_411 enrofloxacin 100 µM -1.34886787816251 0.0808106442395889 no 3086 0.0886897036917583 4436 71188 A bacterial gyrase inhibitor.
SGTC_2197 6588183 93.1375 µM -1.34926924543151 0.0807476130009197 no 3087 0.0886252501055567 4395 884136
SGTC_980 1473-0395 201 µM -1.35217555729504 0.0802923092064105 no 3088 0.0881595804869816 4298 768876
SGTC_375 3970-0961 9.27 µM -1.35247090063306 0.0802461494345393 no 3089 0.0881123607978005 4364 2898222
SGTC_1957 st077035 62.4 µM -1.3577507825616 0.079424327162665 no 3090 0.0872713884694614 4415 705593
SGTC_215 1287-0124 461.5 µM -1.36146691943752 0.0788497348759267 no 3091 0.0866830903797964 4426 5560863
SGTC_2636 apigenin dimethyl ether 100 µM -1.3623567671955 0.0787126143392227 no 3092 0.086542660266586 4390 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2824 7998404 51.95 µM -1.36474509734746 0.0783454794794229 no 3093 0.0861665900703363 4364 837851
SGTC_2281 7943571 200 µM -1.36484259322455 0.0783305200143506 no 3094 0.0861512642281108 4495 1244024
SGTC_441 propafenone 146 µM -1.36621029314446 0.0781208926354953 no 3095 0.0859364838480432 4404 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2513 baicalein 25.65 µM -1.36903578474166 0.0776891775769514 no 3096 0.0854940446660618 4403 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2674 ligustilide 100 µM -1.37136045501621 0.0773353444847408 no 3097 0.0851313092413142 4473 5319022 A signalling regulator.
SGTC_1165 k072-0275 30.3 µM -1.37325977712569 0.0770471624668262 no 3098 0.084835801099473 4389 6153523 YGL055W OLE1
SGTC_191 3914-0123 66.505 µM -1.37517357575019 0.0767576101705951 no 3099 0.0845388191917761 4444 3144412
SGTC_2090 5301565 104.445 µM -1.37520777483808 0.0767524434810658 no 3100 0.0845335193034814 4427 2056344
SGTC_2224 6650123 117.647 µM -1.37694300691021 0.0764906370974779 no 3101 0.0842649346141265 4439 2908370
SGTC_2304 7443016 91.4 µM -1.3779960591493 0.0763320874364668 no 3102 0.0841022524357148 4368 939854
SGTC_1736 st036774 51 µM -1.37823778674679 0.0762957277593874 no 3103 0.0840649421216744 4463 1272247
SGTC_2919 7978188 46.38 µM -1.38445734597744 0.0753647328098402 no 3104 0.0831092300371028 4436 2980291
SGTC_807 1315-0151 48 µM -1.38449380945616 0.0753593003026443 no 3105 0.0831036511666342 4444 4011080
SGTC_850 0388-0143 75.9 µM -1.38500303749327 0.075283464209674 no 3106 0.0830257692878109 4416 67273
SGTC_338 4055-0136 114 µM -1.38514028642313 0.0752630345559925 no 3107 0.083004787685013 4404 2900563
SGTC_383 2324-0395 7.37 µM -1.38570775375644 0.0751786112819841 no 3108 0.0829180798016419 4412 3146421
SGTC_3077 9117319 49.47 µM -1.38839599156089 0.0747796575900341 no 3109 0.082508248152749 4391 17154678
SGTC_315 k915-0449 187 µM -1.38994852424797 0.074549987652813 no 3110 0.0822722545619147 4463 20970215 YNL149C PGA2
SGTC_2567 aureobasidin a 60 nM -1.39923683515204 0.0731871768359008 no 3111 0.0808709870260144 4522 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1150 3909-7983 10.9 µM -1.39925878111035 0.0731839795797796 no 3112 0.0808676976521112 4428 23965914
SGTC_1502 4534-4282 27.7 µM -1.40503027597608 0.072346847808095 no 3113 0.0800061377640872 4416 3278949
SGTC_3337 9144342 33.5465 µM -1.40985301851203 0.0716529724874184 no 3114 0.0792915438290877 4435 17682949
SGTC_1924 st058459 75.1 µM -1.41108713330316 0.0714762364291436 no 3115 0.0791094617014926 4404 688683
SGTC_1156 4092-0367 4.88 µM -1.41617922646675 0.0707505402139934 no 3116 0.0783615182187007 4490 1357585
SGTC_1262 0737-0114 49.6 µM -1.41677208380046 0.0706664188225309 no 3117 0.0782747870233675 4469 765919
SGTC_189 3970-0742 2.116 µM -1.41771210701219 0.0705331951457727 no 3118 0.0781374169576516 4419 2891807
SGTC_2974 9094440 9.66 µM -1.41911881422813 0.0703341919656792 no 3119 0.0779321898341832 4438 25236134
SGTC_922 1866-0035 480 µM -1.42668893835312 0.0692706717734758 no 3120 0.0768347877365122 4385 3156169
SGTC_8 0354-0001 70 µM -1.42718919930917 0.0692008293406878 no 3121 0.0767626834280765 4455 4993152
SGTC_3275 9138069 49.47 µM -1.42735321859871 0.0691779420940169 no 3122 0.0767390539747542 4508 17617007
SGTC_1729 st035615 45.989 µM -1.42943734207359 0.068887631232945 no 3123 0.0764392859973612 4459 17385451
SGTC_1701 st028638 40.4 µM -1.4304284700375 0.0687499006386123 no 3124 0.0762970409716599 4473 3490878
SGTC_1993 st073995 70.8 µM -1.43184861126496 0.0685529230835604 no 3125 0.0760935758912315 4468 3098394
SGTC_734 2023-0417 80 µM -1.4325185853413 0.0684601470687584 no 3126 0.0759977315359643 4455 3935732
SGTC_1722 st034304 3.6505 µM -1.43530617675677 0.068075169379697 no 3127 0.0755999342035724 4414 4036148 YLR033W RSC58
SGTC_1883 5-benzylidenerhodanine 20 µM -1.43634521049274 0.0679321029378156 no 3128 0.0754520676408962 4441 1273210
SGTC_201 4262-0159 12.803 µM -1.43745188641886 0.0677799781753327 no 3129 0.0752948173190922 4508 1341029
SGTC_3092 9117248 49.47 µM -1.44294516879565 0.0670287578969345 no 3130 0.0745179588707448 4581 17141857
SGTC_1985 st071382 65.5 µM -1.4459654079653 0.0666184849407078 no 3131 0.0740934522330425 4453 6123237
SGTC_1023 4482-3888 16 µM -1.44763880286724 0.0663920072117485 no 3132 0.0738590465867802 4470 3303168
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.44915759022108 0.0661869706112861 no 3133 0.0736467890345465 4419 6857784
SGTC_2063 5246145 200 µM -1.44970136232567 0.0661136806200531 no 3134 0.0735709078458281 4503 711240
SGTC_2644 guaiazulene 100 µM -1.4528303549601 0.0656931738480452 no 3135 0.0731354308329932 4495 3515 A coloring agent.
SGTC_2268 7933382 153.85 µM -1.45315153663931 0.0656501276986482 no 3136 0.0730908422843503 4507 935025 YOR257W CDC31
SGTC_2608 thymoquinone 42.66 µM -1.45388135506236 0.0655523956010889 no 3137 0.0729896014446339 4431 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2947 9072639 7.68 µM -1.45418171173654 0.0655122067543531 no 3138 0.0729479669799045 4413 16488146
SGTC_1523 st012844 44.7 µM -1.45470595596419 0.0654421066982197 no 3139 0.0728753415085291 4507 4274103
SGTC_1138 3761-0006 1.03 µM -1.45839267010545 0.0649507744855378 no 3140 0.0723661699474116 4504 12061087
SGTC_988 1497-1057 103 µM -1.45918275072873 0.0648458531616811 no 3141 0.0722574075460319 4459 3533044
SGTC_3169 9102970 49.47 µM -1.46161116707835 0.0645241874385072 no 3142 0.0719238962545651 4546 17027839
SGTC_1337 1486-1011 40.3 µM -1.46283246976349 0.0643628839896546 no 3143 0.0717566129922328 4462 X1337
SGTC_2003 4023581 200 µM -1.46439430810839 0.0641570611110393 no 3144 0.0715431212103855 4492 16641307
SGTC_1516 st013856 110 µM -1.46771201712209 0.0637215433980153 no 3145 0.0710912325496425 4495 5281404 A mutagen and neurotoxin.
SGTC_177 1327-0068 8.361 µM -1.46795951461273 0.0636891466611601 no 3146 0.0710576102006289 4452 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2408 sulbentine 18.36 µM -1.47318385903503 0.0630082803439236 no 3147 0.0703507330810198 4357 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.47685374832904 0.062533399334034 no 3148 0.0698574226435801 4456 521171
SGTC_570 0987-0065 62.6 µM -1.47866172129162 0.0623004771423975 no 3149 0.069615373869136 4335 3104428
SGTC_3207 9114163 49.47 µM -1.48022059261727 0.0621001905627771 no 3150 0.0694071932950135 4457 849233
SGTC_1131 3454-3128 32.3 µM -1.48123647366674 0.0619699389411748 no 3151 0.0692717850073102 4478 710982
SGTC_3054 9094397 49.47 µM -1.48589764699038 0.0613750360062358 no 3152 0.068653098048235 4476 2598354
SGTC_2891 9063876 19.48 µM -1.48906061699251 0.0609738953329701 no 3153 0.0682357036276542 4518 6472478
SGTC_2045 5106652 78.05 µM -1.49194868152273 0.0606094121398804 no 3154 0.0678562995972129 4480 673349
SGTC_3119 9125183 49.47 µM -1.49409307436901 0.0603398870051611 no 3155 0.0675756469518315 4357 22695334
SGTC_1124 fisetin 1.16336 µM -1.49416266206517 0.0603311563840471 no 3156 0.067566554540044 4505 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1467 k284-1082 293 µM -1.497737284008 0.0598840050493488 no 3157 0.0671007604525158 4462 3334705
SGTC_640 3381-0960 37.1 µM -1.50060044039021 0.0595277270366895 no 3158 0.066729468688439 4541 1745025
SGTC_2206 7254556 146.969 µM -1.50882245870679 0.0585138483158687 no 3159 0.0656720798907165 4528 4398905
SGTC_2769 toremifene 3.73 µM -1.51196047593457 0.0581304852431271 no 3160 0.0652719588018143 4498 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1644 st010134 20.9 µM -1.51357521240741 0.057933987753044 no 3161 0.0650668059378306 4480 3818134
SGTC_806 3966-4455 5.86 µM -1.51375432502499 0.057912223721364 no 3162 0.0650440804817597 4480 714982
SGTC_1476 4112-3294 3.34 µM -1.51768143950188 0.0574366521206192 no 3163 0.064547362632792 4494 704369
SGTC_2036 5160441 105 µM -1.521435939336 0.0569848620730354 no 3164 0.064075237866638 4479 134534 YIL048W NEO1
SGTC_1443 4112-3303 14 µM -1.52779692612446 0.0562258169515214 no 3165 0.0632814828534936 4551 704433
SGTC_3109 9122853 49.47 µM -1.53643024616863 0.0552083962974636 no 3166 0.0622164466723576 4529 1234709
SGTC_3192 9110362 49.47 µM -1.53804432583788 0.0550198035808539 no 3167 0.0620188885982951 4511 16649480
SGTC_616 4092-0450 108 µM -1.54477366917897 0.0542390114528643 no 3168 0.0612005091844795 4528 787165
SGTC_2639 lactacystin 53 µM -1.54524896489183 0.0541841970442858 no 3169 0.0611430273682279 4534 3870 A proteasome inhibitor.
SGTC_2071 5230951 39.92 µM -1.54841979095428 0.05381963625156 no 3170 0.0607606296652463 4554 1799272
SGTC_1569 carminic acid 40.6 µM -1.55115782274309 0.0535064004782816 no 3171 0.0604319334889545 4590 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1603 st002045 67.8 µM -1.55326362357698 0.0532664771292138 no 3172 0.0601800834617858 4508 5887985
SGTC_3214 9129694 49.47 µM -1.55552234872623 0.0530100791646246 no 3173 0.0599108580932781 4524 17158655
SGTC_2950 9072895 21.46 µM -1.55863496022813 0.0526583575583594 no 3174 0.0595414018035142 4463 17332245
SGTC_1423 4048-0112 5.59 µM -1.56538100465096 0.0519024189403676 no 3175 0.0587467998283239 4586 X1423
SGTC_362 0310-0100 9.03 µM -1.56663257950449 0.0517631247533309 no 3176 0.0586002990347542 4547 790235
SGTC_1741 st038134 10.228 µM -1.56677352884436 0.0517474564115418 no 3177 0.0585838184538622 4550 1272587
SGTC_1959 st077091 55.8 µM -1.56715714073194 0.051704832081209 no 3178 0.0585389828466504 4524 821356 YKL052C ASK1
SGTC_795 0685-0265 78 µM -1.56786197514846 0.0516265884538161 no 3179 0.0584566737777454 4529 302754
SGTC_753 1322-0200 289 µM -1.56863700651392 0.0515406609645418 no 3180 0.0583662721954352 4577 5403907
SGTC_595 3909-8003 73.7 µM -1.57168112235546 0.0512042608120022 no 3181 0.0580122611683028 4584 699517
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.57187742615205 0.0511826277094914 no 3182 0.0579894903488537 4522 551469
SGTC_180 1486-1293 102.781 µM -1.57280970571341 0.0510799877514921 no 3183 0.0578814438041573 4454 4140536
SGTC_836 0330-0104 1.35 µM -1.57319045994462 0.0510381154940678 no 3184 0.0578373618299855 4571 46494820
SGTC_879 0831-1030 162 µM -1.5762385705114 0.050703893021981 no 3185 0.0574854163318603 4536 1549252
SGTC_225 nsc-122657 1.016 µM -1.58289482804668 0.0499800999425655 no 3186 0.0567227188847892 4549 275685
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.58476636470969 0.0497780822988902 no 3187 0.0565097135683367 4519 5282362
SGTC_303 1348-1668 34.2 µM -1.58506387273021 0.0497460287396462 no 3188 0.0564759114088719 4553 5380509
SGTC_1563 conessine 56.1 µM -1.5887039922532 0.0493551735667177 no 3189 0.0560636186018934 4592 441082 An anti-amoebic, histamine inhibitor.
SGTC_1769 st044406 64.4 µM -1.58894931533305 0.0493289206152749 no 3190 0.0560359180472059 4521 670903
SGTC_2480 5767542 37.17 µM -1.59978280657514 0.048180663275366 no 3191 0.0548233871617993 4477 2867358
SGTC_847 0342-0274 5.54 µM -1.60361538934934 0.0477796007980214 no 3192 0.0543994282123701 4539 18097
SGTC_2831 7999036 19.48 µM -1.60396625888947 0.047743017846312 no 3193 0.0543607450878929 4513 2988270
SGTC_3187 9109394 49.47 µM -1.60622746150131 0.0475077942742819 no 3194 0.0541119708233489 4559 17098090
SGTC_156 3474-0145 5.642 µM -1.60710273887317 0.0474169924013103 no 3195 0.0540159163003907 4470 2265471
SGTC_2068 5226020 147 µM -1.61135157179116 0.0469781896956279 no 3196 0.0535515580895843 4559 1810509
SGTC_884 0851-0618 334 µM -1.61247462222021 0.0468627512261878 no 3197 0.0534293489917872 4564 9642473
SGTC_98 0074-0023 107.663 µM -1.62311877426371 0.0457798999937213 no 3198 0.0522820084860632 4546 3563821
SGTC_3306 9127676 59.7925 µM -1.62747216944869 0.0453428550672022 no 3199 0.0518184273596865 4518 41905287
SGTC_787 4152-0075 138 µM -1.62795187247383 0.045294902814941 no 3200 0.051767545550016 4586 9566539
SGTC_1590 st077108 57.8 µM -1.63288240194609 0.0448043963255282 no 3201 0.0512468660001324 4574 5489485
SGTC_1267 0828-0272 9.49 µM -1.63347275357843 0.0447459538569572 no 3202 0.051184803289409 4604 745334
SGTC_376 3970-0862 59.1 µM -1.63381407504985 0.0447121924021337 no 3203 0.0511489480093943 4573 3135186
SGTC_1142 3253-1408 9.78 µM -1.63392366052304 0.0447013572217351 no 3204 0.0511374404684943 4568 256655
SGTC_32 0928-0142 34.1 µM -1.63468222264133 0.0446264129365258 no 3205 0.0510578405438561 4569 2244242
SGTC_2657 nystatin 74.44 µM -1.6351990687905 0.0445754076561888 no 3206 0.0510036616579121 4586 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2693 st077581 40.7 µM -1.636002527556 0.0444962110850243 no 3207 0.0509195292037993 4512 25238761
SGTC_174 3553-0389 74.3 µM -1.64171554667903 0.0439363450309048 no 3208 0.0503244841081451 4583 738071
SGTC_2116 5511452 16.8835 µM -1.64242930759997 0.0438667986928827 no 3209 0.0502505326700026 4566 870744
SGTC_2704 st078022 71.1 µM -1.65247067170852 0.0428977837880791 no 3210 0.0492193195390675 4603 54697681
SGTC_3190 9110366 49.47 µM -1.65478922277566 0.0426765144570769 no 3211 0.0489836304343609 4576 17123768
SGTC_56 0957-0365 83.25 µM -1.65491925095654 0.042664132681946 no 3212 0.0489704393470424 4522 6752360
SGTC_2989 9073649 71.4286 µM -1.66750015353255 0.0414797990561056 no 3213 0.047707496956111 4535 21367202
SGTC_47 0149-0135 24.25 µM -1.68609435983566 0.0397783110777242 no 3214 0.0458888130921069 4594 5239155
SGTC_476 mead acid 10 µM -1.68759175660861 0.0396437952058479 no 3215 0.045744811366575 4646 5312531 An omega 9 fatty acid.
SGTC_904 1141-0088 396 µM -1.69292777285118 0.0391674489447049 no 3216 0.045234608070888 4599 1378119
SGTC_2185 6113692 200 µM -1.69792862883333 0.038725261523686 no 3217 0.0447606165651605 4578 874150
SGTC_2359 9039622 200 µM -1.69915067257018 0.038617826161587 no 3218 0.0446453989043817 4542 6463596
SGTC_17 0960-0276 49.807 µM -1.70311034347026 0.0382713810006641 no 3219 0.0442737103084017 4586 6821114
SGTC_1127 asiatic acid 681.4 nM -1.70472658978957 0.0381307003216671 no 3220 0.0441227141710127 4535 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2836 9010338 19.48 µM -1.71091704425451 0.0375957697231157 no 3221 0.0435482138649501 4546 2994051
SGTC_1507 4075-3230 155 µM -1.71662752299515 0.0371077630157647 no 3222 0.0430236251684847 4559 659771
SGTC_2471 5466956 24.79 µM -1.71747674676665 0.0370356341199601 no 3223 0.0429460497790333 4596 724419
SGTC_1932 st074806 40.9 µM -1.73413050625234 0.0356441563414607 no 3224 0.0414474649189253 4620 17251235
SGTC_1144 3486-0183 12.5 µM -1.7380048814023 0.0353266599229649 no 3225 0.0411049768284406 4605 6744069
SGTC_1913 st060213 96.1 µM -1.73941335723389 0.0352118148949254 no 3226 0.0409810402015594 4574 688959
SGTC_285 1486-1325 46 µM -1.74249512324505 0.0349616003527792 no 3227 0.0407109220317901 4634 22310230
SGTC_2239 6685329 187.64 µM -1.74848148324562 0.0344797269444661 no 3228 0.0401903445998203 4605 805680
SGTC_2849 9019321 12.99 µM -1.75493215348016 0.0339666004897879 no 3229 0.0396354567721144 4611 16489627
SGTC_357 1325-0123 420 µM -1.76174773928694 0.0334312867753451 no 3230 0.0390559640343787 4601 1098503
SGTC_1442 4112-3290 3 µM -1.76508169983674 0.0331719699155425 no 3231 0.0387750179057732 4628 704353
SGTC_1776 st049249 45.9 µM -1.76905710020875 0.0328649297841219 no 3232 0.0384421730520254 4621 1822314
SGTC_1243 0416-0003 5.65 µM -1.77132662277138 0.0326906961332338 no 3233 0.0382532013885784 4595 2141977
SGTC_2749 bexarotene 57.39 µM -1.78188203354863 0.0318903269958593 no 3234 0.0373842354876706 4616 82146 An retinoic acid receptor inhibitor.
SGTC_2682 pyrogallin 40.03 µM -1.78825598498969 0.0314149054295179 no 3235 0.036867358784561 4639 822798 An ATP competetive kinase inhibitor.
SGTC_783 0848-0141 92.7 µM -1.78839014090224 0.0314049622930146 no 3236 0.0368565429153201 4576 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_555 4296-0685 37 µM -1.79487832408421 0.0309271793366279 no 3237 0.0363365440856544 4606 2908540 YHR072W ERG7
SGTC_3257 9139206 32.98 µM -1.79567378868698 0.0308690183455109 no 3238 0.0362732064434461 4617 4910041
SGTC_2227 7312221 64.1025 µM -1.79639468400479 0.0308163877730587 no 3239 0.0362158843592854 4711 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3339 9145883 14.936 µM -1.79652114065577 0.0308071631853446 no 3240 0.0362058367922184 4561 2030670
SGTC_37 0566-0070 1.56 µM -1.80188015562216 0.0304183371180292 no 3241 0.0357821315119199 4556 1626686
SGTC_332 4112-0506 40.9 µM -1.816872027614 0.0293521407829624 no 3242 0.0346183553533843 4634 2790355
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.82152813155033 0.0290273914697371 no 3243 0.0342633072082255 4642 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2240 6690706 185.951 µM -1.82938865848165 0.0284859205367115 no 3244 0.0336707027145621 4540 805876
SGTC_1512 0259-0544 12.2 µM -1.83784164553629 0.0279130418787801 no 3245 0.0330428714822543 4612 18476
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.84389967358879 0.0275084054620589 no 3246 0.0325988813447991 4629 97141
SGTC_2266 7929956 200 µM -1.84549981833485 0.0274023465310068 no 3247 0.0324824324486383 4610 2967153
SGTC_3089 9117425 49.47 µM -1.84563722192668 0.0273932552253273 no 3248 0.0324724490616708 4607 9401657
SGTC_1282 0886-0010 32.4 µM -1.85510557632932 0.0267728130421339 no 3249 0.0317905758287468 4655 2836211 YNL267W PIK1
SGTC_877 0771-0151 33.1 µM -1.86162214203713 0.0263526487483704 no 3250 0.0313281850034417 4651 6166523
SGTC_2303 7774051 200 µM -1.87912475459247 0.0252513470671608 no 3251 0.0301137303933693 4642 2953184
SGTC_3121 9125696 49.47 µM -1.88019235775025 0.0251854380492331 no 3252 0.0300409333880554 4728 1235365
SGTC_802 4112-3352 742 µM -1.88107294825572 0.0251311829050892 no 3253 0.0299809981464745 4669 704594
SGTC_2587 piperic acid 92.2 µM -1.88306969402255 0.0250085217621683 no 3254 0.0298454618225073 4601 5370536
SGTC_82 0054-0107 293.755 µM -1.88516753576979 0.0248801913193104 no 3255 0.0297036111626988 4631 3104697
SGTC_2850 9015429 58.44 µM -1.90076607209161 0.0239432030639228 no 3256 0.0286663299410378 4650 6457570
SGTC_2814 7977482 42.97 µM -1.90758233170639 0.0235431668479054 no 3257 0.0282226102611634 4632 6456762
SGTC_3186 9110464 49.47 µM -1.90939166818483 0.0234379287924626 no 3258 0.0281057923995716 4659 17018021
SGTC_1011 4112-3381 17.4 µM -1.91297859354055 0.0232304690967504 no 3259 0.0278753964717541 4679 2877139
SGTC_2978 9011784 42.97 µM -1.91522048388233 0.0231015898595788 no 3260 0.0277321956211992 4635 2994934
SGTC_173 1273-0061 2.693 µM -1.91625517969625 0.0230423118093108 no 3261 0.0276663114229664 4614 2847414 YPL266W DIM1
SGTC_2730 imipramine 71.33 µM -1.93059332819682 0.0222339753362471 no 3262 0.0267666817970777 4641 3696 A tricyclic antidepressant.
SGTC_2890 9046729 58.44 µM -1.93636653794118 0.0219153258259793 no 3263 0.0264114123774303 4644 903329
SGTC_1025 k007-0731 70 µM -1.93692833527416 0.021884524610379 no 3264 0.0263770521050791 4649 6256118
SGTC_1448 4255-0083 152 µM -1.94049429629737 0.0216898677826155 no 3265 0.0261598233403316 4682 5399660
SGTC_918 glabranin 770.725 nM -1.95464117902329 0.0209319767735149 no 3266 0.025312718650664 4654 124049 Also referred to as licorice root.
SGTC_1021 4476-0760 85.3 µM -1.9613977600845 0.0205779900232438 no 3267 0.0249163205478188 4690 746768
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.96279525729328 0.0205054096066844 no 3268 0.0248349845617471 4679 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3309 9129340 25.759 µM -1.964856857077 0.020398734433385 no 3269 0.0247154036610416 4653 17158987
SGTC_3322 9139058 2.11 µM -1.96887221010229 0.0201923142409373 no 3270 0.0244838837459269 4692 4908926 YPR165W RHO1
SGTC_596 1155-0152 116 µM -1.97773528922951 0.0197429460477246 no 3271 0.0239792885028169 4691 280313
SGTC_63 0099-0242 26.702 µM -1.97810291085241 0.0197244920514056 no 3272 0.0239585491352157 4675 3898502 YLR359W ADE13
SGTC_2316 5844804 197.44 µM -1.98709408666172 0.0192776876611662 no 3273 0.0234559857134073 4655 776813
SGTC_2897 9048598 12.99 µM -1.99369188261203 0.0189553168907601 no 3274 0.0230928685133668 4664 6467404
SGTC_1054 3429-0080 167 µM -1.99615602969071 0.0188360994464756 no 3275 0.0229584709310589 4677 1162877
SGTC_2925 9010536 32.5 µM -2.00711827347651 0.0183134395655927 no 3276 0.0223685354705037 4626 2994177
SGTC_2857 9024691 58.44 µM -2.01598970482463 0.0178995593490332 no 3277 0.0219005261727413 4677 16478292
SGTC_460 trequinsin 123 µM -2.02212557120295 0.0176179915050783 no 3278 0.0215816904525646 4753 5537 A vasodilator.
SGTC_2837 9008476 45.46 µM -2.02395370131892 0.0175348351384877 no 3279 0.0214874578575106 4659 2992805
SGTC_2553 4-methylesculetin 85.09 µM -2.03697363777479 0.0169522315117035 no 3280 0.0208263419328689 4680 5319502
SGTC_1870 st057514 26.5 µM -2.04834776155681 0.0164568960772777 no 3281 0.0202629680988813 4694 5393161
SGTC_392 N-ethylmaleimide 8.33 µM -2.05183023925669 0.0163077361026467 no 3282 0.0200930817066568 4688 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2025 5147754 141 µM -2.05770364376367 0.0160587919475875 no 3283 0.0198092951952801 4693 315777 YLR208W SEC13
SGTC_2980 9014342 25.29 µM -2.05933206769001 0.0159903506050002 no 3284 0.0197312192622907 4687 2996599
SGTC_572 0960-0087 17.7 µM -2.06783664774812 0.0156369589310942 no 3285 0.0193276931446264 4688 6796365
SGTC_6 0844-0013 19.835 µM -2.07771206667771 0.0152350328966705 no 3286 0.0188679434930064 4769 1584900
SGTC_365 0121-0052 13.6 µM -2.08185831527668 0.0150689458101136 no 3287 0.0186777066418349 4662 3101739
SGTC_254 nsc-64875 3.808 µM -2.08546575053838 0.0149257102681791 no 3288 0.0185135219621214 4698 56993
SGTC_257 daunorubicin 18.5 µM -2.08864767631181 0.0148003429613225 no 3289 0.0183697250600763 4722 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2364 9055074 200 µM -2.10935020561075 0.0140065760917227 no 3290 0.0174571820955805 4694 6470630
SGTC_3056 9094900 49.47 µM -2.10977362188179 0.0139907322219861 no 3291 0.0174389297874301 4682 25236784
SGTC_311 1315-0136 58 µM -2.11255299452409 0.0138871135642235 no 3292 0.0173195227862563 4722 6759207
SGTC_3348 9149464 3.537 µM -2.12154139753315 0.0135565320036908 no 3293 0.0169381340181607 4678 1951442
SGTC_3313 9133968 57.047 µM -2.12258464306908 0.013518606332536 no 3294 0.0168943364744977 4708 1494643
SGTC_1686 st019653 115.5 µM -2.12346636273366 0.0134866241477145 no 3295 0.0168573956570982 4722 97252
SGTC_1163 k060-0048 49.9 µM -2.15677443457495 0.0123253673244507 no 3296 0.015511622009056 4717 6809982
SGTC_774 k060-0086 136 µM -2.15791346645407 0.012287237086775 no 3297 0.0154672801488884 4711 5911235
SGTC_1376 2910-0861 41.3 µM -2.16178591475695 0.0121583663762713 no 3298 0.0153173408353014 4676 1112859
SGTC_1034 k072-0165 12.7 µM -2.17673825581895 0.0116717028920727 no 3299 0.0147500511122474 4723 5835461
SGTC_1632 st005650 90 µM -2.18179017957417 0.0115111411379438 no 3300 0.0145625108452223 4718 2759605
SGTC_2283 7944793 200 µM -2.18440653121828 0.0114287440301114 no 3301 0.014466194363847 4694 2970533
SGTC_3209 9113616 49.47 µM -2.21102033723054 0.0106192891462036 no 3302 0.0135172143826551 4711 16649353
SGTC_83 0170-0301 39.027 µM -2.21923177933617 0.0103798357300404 no 3303 0.0132354800469027 4738 3089716
SGTC_1175 0741-0056 27.6 µM -2.23218982998364 0.0100115391512828 no 3304 0.0128012096472128 4738 765927
SGTC_3164 9100705 49.47 µM -2.23426462346103 0.00995364074424873 no 3305 0.0127328332867491 4739 17174235
SGTC_1841 st054148 70 µM -2.24879627110994 0.00955625785544704 no 3306 0.0122627303667027 4745 675442
SGTC_2046 4110841 106 µM -2.25728994616567 0.00933047035958043 no 3307 0.0119949815876634 4740 44119630 YMR134W ERG29
SGTC_989 1501-0895 10.3 µM -2.27394397388553 0.00890126963674727 no 3308 0.0114846776545833 4737 2830112
SGTC_521 r062-0005 13.8 µM -2.28317406163873 0.00867092711694203 no 3309 0.0112100586819464 4692 2832033
SGTC_1703 st026983 48.3 µM -2.2962950877312 0.00835248590112945 no 3310 0.010829507394195 4754 1104023
SGTC_1431 4049-0260 9.09 µM -2.31567399440824 0.00790095453842211 no 3311 0.0102880376770078 4766 3854841
SGTC_310 1273-0058 1.06 µM -2.32776869024235 0.00763015427221703 no 3312 0.00996219473082056 4396 2734232
SGTC_2812 7970281 58.44 µM -2.36135087767246 0.00692062905564514 no 3313 0.00910424669227253 4740 2233435
SGTC_578 3460-0051 92 µM -2.38655978714502 0.00642694960783483 no 3314 0.00850342091331106 4770 2876744
SGTC_1763 st044482 94.5 µM -2.39808871808241 0.00621174698558611 no 3315 0.00824043647815158 4750 88505
SGTC_1379 2144-0755 36.5 µM -2.41810218307292 0.00585328912314108 no 3316 0.00780084744296185 4759 5392327
SGTC_3045 9092950 49.47 µM -2.45194741588978 0.00528869699190764 no 3317 0.0071042711929496 4741 44120432
SGTC_1495 4469-0029 237 µM -2.45278663725544 0.00527533508723811 no 3318 0.00708771957077279 4757 793680
SGTC_941 3237-0776 460 µM -2.48151039474998 0.00483573124543174 no 3319 0.00654134472531459 4746 760008
SGTC_2699 st077704 54.6 µM -2.49254298817037 0.00467576119237866 no 3320 0.00634159881887209 4750 645852
SGTC_1384 3089-0840 101 µM -2.49262628559085 0.00467457157384155 no 3321 0.00634011147786858 4764 1069836
SGTC_1028 k015-0029 4.8 µM -2.50931059472136 0.00444166774837101 no 3322 0.00604835343797166 4752 4588309
SGTC_2832 7992762 51.95 µM -2.53269782743483 0.00413264610641556 no 3323 0.00565942399854458 4700 2985177
SGTC_433 pimozide 108 µM -2.53706516642096 0.00407711896131571 no 3324 0.00558930716846523 4723 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2402 5553605 200 µM -2.53869819472211 0.00405652848401015 no 3325 0.00556328804507535 4757 6758546
SGTC_1154 4088-0362 150 µM -2.5608716035066 0.00378601794756035 no 3326 0.00522049678400094 4784 6618304
SGTC_930 2810-3379 265 µM -2.57488060076904 0.00362356099759421 no 3327 0.0050137347713175 4755 1015764
SGTC_278 4092-0821 23.9 µM -2.59119351014434 0.0034422905152855 no 3328 0.00478218468597179 4749 877900
SGTC_983 1491-0821 12.2 µM -2.60694189593462 0.00327506516692837 no 3329 0.00456774304634892 4774 46495113
SGTC_1114 scopoletin 1.73284 µM -2.614133535566 0.00320115935464044 no 3330 0.00447270332885392 4788 5280460 A coumarin with genotoxic properties.
SGTC_1161 k007-0610 110 µM -2.61953574545485 0.00314663355694977 no 3331 0.00440247721758155 4727 5843850
SGTC_946 3434-1334 87.4 µM -2.63541441968814 0.00299117263687835 no 3332 0.00420173068592142 4752 4047976
SGTC_574 1315-0397 40 µM -2.66032734101114 0.00276117304798527 no 3333 0.00390323702764575 4770 6794277
SGTC_3046 9092212 49.47 µM -2.68405852701565 0.00255705416210343 no 3334 0.00363671861304849 4788 25236637
SGTC_1153 4055-0057 267 µM -2.70365783536691 0.00239886823229582 no 3335 0.00342904343532193 4787 882706
SGTC_636 0kpi-0074 126 µM -2.70866980158189 0.00235986487304242 no 3336 0.00337767672240287 4785 616434
SGTC_68 0986-0284 82.829 µM -2.72039283057294 0.00227086785974594 no 3337 0.00326022019590729 4721 423278 YIL048W NEO1
SGTC_344 k064-0035 6.43 µM -2.74898556289121 0.00206641387517517 no 3338 0.00298900095998304 4750 5088750
SGTC_78 0336-0123 156.75 µM -2.76419921224527 0.00196457374259014 no 3339 0.00285313448580894 4739 6765896
SGTC_573 3702-0553 84.7 µM -2.83361815956363 0.00155531038941886 no 3340 0.00230121447345585 4783 1222756
SGTC_2703 st077852 53.4 µM -2.83439349118963 0.00155121475236284 no 3341 0.00229563799221135 4780 6281836
SGTC_260 nsc-65238 3.989 µM -2.84687608726336 0.00148661579508247 no 3342 0.00220752720241999 4790 3246252
SGTC_910 3454-3003 490 µM -2.86119689560303 0.00141553319270918 no 3343 0.00211022425648633 4728 820824
SGTC_2842 9000675 19.48 µM -2.87908731300096 0.00133109669624635 no 3344 0.00199413949293692 4769 2989072
SGTC_3178 9107506 49.47 µM -2.89119208684794 0.00127660503316584 no 3345 0.0019189173363146 4778 8897194
SGTC_2104 5389443 200 µM -2.97564976305968 0.000949699485611064 yes 3346 0.00146184277583726 4792 2244536
SGTC_2338 7999974 200 µM -3.01343529359967 0.000830006937951414 yes 3347 0.00129154059446965 4770 315925
SGTC_631 k072-0230 41.5 µM -3.14528608758275 0.000512791669404148 yes 3348 0.00082962243231574 4796 5773147
SGTC_2287 7945887 168.79 µM -3.17255589500052 0.000463143226786523 yes 3349 0.000755517347718156 4789 1245853
SGTC_591 4299-0174 154 µM -3.3154792008756 0.000268206087040071 yes 3350 0.000457430743874748 4807 5509088
SGTC_1046 2001-0062 216 µM -3.4081460207381 0.000186095780052188 yes 3351 0.000327029421230211 4798 739778
SGTC_343 4130-2827 29.8 µM -3.44155948432495 0.000162761594731455 yes 3352 0.000289185645096593 4795 1118244
SGTC_647 0140-0236 81 µM -3.48494876853176 0.00013653492387207 yes 3353 0.000246115638396409 4805 990837
SGTC_2123 5259487 200 µM -3.70279001865252 5.48598062911562e-05 yes 3354 0.000106620686296126 4806 2173474
SGTC_2809 7964133 12.99 µM -3.81577606565541 3.35265673501469e-05 yes 3355 6.78777906779872e-05 4800 1253665
SGTC_3166 9102297 49.47 µM -4.47896080769092 1.4208581435328e-06 yes 3356 3.75036511895298e-06 4809 25237072