SGTCid condition conc unit YHL044W|YHL044W.score YHL044W|YHL044W.strain.pval YHL044W|YHL044W.strain.significant YHL044W|YHL044W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2367 9070478 135.38 µM 6.64077823061461 4.37429656410908e-13 yes 1 1.5601561111367e-11 7 572802 SGTC_138 0850-0259 40.9225 µM 5.56464272408016 1.04730808382704e-09 yes 2 1.31345026619291e-08 122 6813004 SGTC_3311 9131146 2.8755 µM 5.46115545235325 2.0652863514639e-09 yes 3 2.36522798035456e-08 72 4900406 YPR165W RHO1 SGTC_2293 7624732 200 µM 4.8325029364168 9.8547254451887e-08 yes 4 6.74135613119813e-07 10 894453 SGTC_101 0490-5701 117.494 µM 4.65996435322872 2.63382252284018e-07 yes 5 1.58132075066345e-06 6 4661669 SGTC_514 4466-0038 2.65 nM 4.53158558808663 5.35608485656236e-07 yes 6 2.92713046009186e-06 127 5722064 SGTC_1596 piperlongumine 63 µM 4.53052810148693 5.38707934024626e-07 yes 7 2.94182138323205e-06 4 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2412 st077135 33.4 µM 4.32121895534826 1.64686230041295e-06 yes 8 7.75848006740986e-06 16 13258915 SGTC_2523 spermine 47.74 µM 4.22702846759393 2.67986619144449e-06 yes 9 1.18398859362761e-05 27 1103 A DNA binding polyamine. SGTC_1464 k208-0027 110 µM 4.20656447351848 2.97499427624309e-06 yes 10 1.29641068314321e-05 21 X1464 SGTC_3350 9150499 3.57 µM 4.16054456225357 3.75648499602567e-06 yes 11 1.58744829261925e-05 48 4910996 YPR165W RHO1 SGTC_511 blebbistatin 171 µM 4.14870327846587 3.98731048586645e-06 yes 12 1.67181931641115e-05 19 3476986 A myosin inhibitor. SGTC_2584 androsterone 48.74 µM 4.14527166721732 4.05669869090309e-06 yes 13 1.69705533370986e-05 122 2754130 A steroid. SGTC_951 1171-0579 82.7 µM 4.06495535670628 6.05218771214504e-06 yes 14 2.40208284301798e-05 75 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1068 loratadine 26.9 µM 4.02197526961768 7.47492159672187e-06 yes 15 2.88560592488604e-05 20 3957 A H1 histamine antagonist. SGTC_3075 9116269 49.47 µM 4.01526973197727 7.72381576014637e-06 yes 16 2.96889235320111e-05 20 17015205 YNL244C SUI1 SGTC_1454 4239-0054 42.6 µM 3.98804351483045 8.8179428086919e-06 yes 17 3.33102228722947e-05 36 1340767 SGTC_1601 4'-hydroxyflavanone 55.5 µM 3.81036503164405 2.05149732317782e-05 yes 18 6.93808761296811e-05 34 165506 SGTC_690 glyoxal 20.3 µM 3.77879114418087 2.37490017237826e-05 yes 19 7.87957636456076e-05 90 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1334 1486-0610 236 µM 3.77222477323218 2.4479731380029e-05 yes 20 8.08991985929697e-05 22 3742339 SGTC_2003 4023581 200 µM 3.56526509951096 6.20903966376932e-05 yes 21 0.000181744296322916 46 16641307 SGTC_2806 7952793 58.44 µM 3.53634988175263 7.04475662182693e-05 yes 22 0.00020284849894745 38 2972490 SGTC_2496 diffractaic acid 79.83 µM 3.52801130151668 7.30477688316597e-05 yes 23 0.000209347140054376 28 94870 An apoptosis inducer which activates caspases. SGTC_2194 5927483 104.545 µM 3.52015190556611 7.55810503137272e-05 yes 24 0.00021564985392531 27 760979 SGTC_715 0868-0130 184 µM 3.46460021156853 9.59893137772409e-05 yes 25 0.00026551012657877 15 2876258 SGTC_2171 5739187 198.077 µM 3.44687378404782 0.000103523357781534 yes 26 0.000283556730328103 23 2262761 SGTC_2177 5811945 192 µM 3.42425026844448 0.000113946670477009 yes 27 0.000308249087660728 40 5343475 SGTC_2411 st077133 39.94 µM 3.40970413463019 0.000121160421153117 yes 28 0.000325166941526767 57 1403142 YNL221C POP1 SGTC_2858 9025781 8.96 µM 3.37463012796498 0.000140354791575834 yes 29 0.000369574806368901 136 4894980 YPL153C RAD53 SGTC_1134 3477-0009 42.5 µM 3.36819910108389 0.000144169689867726 yes 30 0.000378304677300158 68 3973534 SGTC_405 ebelactone b 50 µM 3.36450930506646 0.000146402121038549 yes 31 0.000383399492899056 37 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3074 9116018 49.47 µM 3.35224834404092 0.000154055113662527 yes 32 0.000400790396328477 35 17027303 SGTC_1032 k061-1018 98.7 µM 3.30300857621182 0.000188722746814452 yes 33 0.000478267311892781 49 4005393 SGTC_936 3005-4620 401 µM 3.23803932447529 0.000245678741459435 yes 34 0.000601771094293821 54 777207 SGTC_541 4513-1321 94 µM 3.23046575525367 0.00025327343815551 yes 35 0.000617943542423848 45 747515 SGTC_2302 7771753 200 µM 3.22666669571962 0.000257164998908821 yes 36 0.000626206280524072 78 2203047 SGTC_598 3937-0236 20.2 µM 3.20692905005266 0.000278295859852069 yes 37 0.000670800398046959 60 1379313 SGTC_3171 9103192 49.47 µM 3.17058817338518 0.00032148985750962 yes 38 0.000760653272680876 16 13018434 SGTC_1169 aniline yellow 25.8 µM 3.15330516932573 0.000344150061046983 yes 39 0.000807164742587665 29 6051 A DNA damaging agent. SGTC_3153 9100258 49.47 µM 3.14709145250703 0.000352653597086425 yes 40 0.000824516879109389 62 25236848 SGTC_1254 0550-0035 264 µM 3.14520916651557 0.000355267803151399 yes 41 0.000829840609002614 52 15121435 SGTC_1707 st032323 6.317 µM 3.14497744135315 0.000355590875690483 yes 42 0.000830498186645486 100 3132057 YMR211W DML1 SGTC_1992 st073643 23.3 µM 3.13102831387365 0.000375549338748996 yes 43 0.00087097682556855 32 3161292 SGTC_69 0096-0274 206.684 µM 3.05782610929429 0.000498445260097522 yes 44 0.00111474454483597 101 6741392 SGTC_3028 9087778 49.47 µM 3.00420504959811 0.000611045909890141 yes 45 0.00133137899976227 45 17217395 SGTC_1689 st020265 53.493 µM 2.99842770026752 0.000624487248612556 yes 46 0.00135688268282577 46 5758320 YPR016C TIF6 SGTC_989 1501-0895 10.3 µM 2.99131441947643 0.000641411618493658 yes 47 0.0013888966020893 34 2830112 SGTC_684 1140-0066 328 µM 2.9859825885599 0.000654373972210625 yes 48 0.00141334368478892 86 6813534 SGTC_3049 9092223 49.47 µM 2.97541425798784 0.000680784203664626 yes 49 0.00146296565780055 70 8623917 SGTC_1727 st034309 9.9045 µM 2.96886302941589 0.000697645754435167 yes 50 0.00149451899303155 110 870305 SGTC_3321 9137793 26.8275 µM 2.96043093829733 0.000719915104671997 yes 51 0.00153604495202164 127 4904192 SGTC_1989 st071868 50.2 µM 2.88171512991852 0.000961745690519515 yes 52 0.0019775856764437 50 16414057 SGTC_3108 9121785 49.47 µM 2.88030730765133 0.000966681239544666 yes 53 0.00198643860705165 57 17140271 SGTC_2893 9048488 25.97 µM 2.86918052574302 0.00100651548033372 no 54 0.00205768419624906 75 6467338 SGTC_1785 bathophenanthroline 24 µM 2.85184600800603 0.00107158353845115 no 55 0.00217330759571639 116 72812 An iron chelator. SGTC_375 3970-0961 9.27 µM 2.8424652920763 0.0011083828179125 no 56 0.00223830525373401 79 2898222 SGTC_1326 1431-2094 10.8 µM 2.83924512383236 0.00112127974399956 no 57 0.00226102022540884 82 616278 SGTC_724 3910-0327 137 µM 2.8343786406383 0.00114103133059486 no 58 0.00229574468798545 74 2885483 SGTC_863 0466-0191 129 µM 2.83241701211227 0.00114908273044336 no 59 0.00230987781195868 132 765160 YPR165W RHO1 SGTC_1706 st031321 9.9705 µM 2.82835409735264 0.00116592449960448 no 60 0.00233940114823734 49 6103185 SGTC_1135 dihydrocapsaicin 536.708 nM 2.80804528289989 0.00125354862163181 no 61 0.00249216087897956 105 107982 A Capsaicinoid. SGTC_1418 3966-3099 2.4 µM 2.78539232884272 0.00135836538426125 no 62 0.00267314961913224 82 740335 SGTC_1643 st009866 20.2 µM 2.76389132466669 0.00146519848464082 no 63 0.00285582793629908 66 3156273 YOR207C RET1 SGTC_1845 st056753 3.01 µM 2.75920204995212 0.00148949380358079 no 64 0.00289713488309415 97 5375839 SGTC_2544 sphondin 68.51 µM 2.74409550711198 0.00157028187244499 no 65 0.0030338940784941 84 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_377 3970-0964 33.1 µM 2.74299232583195 0.00157633527254795 no 66 0.00304410541519654 138 16481235 SGTC_1627 st003713 25.6 µM 2.73915699471308 0.00159754648249978 no 67 0.00307984759018455 201 16195070 YER133W GLC7 SGTC_2326 6164455 177.58 µM 2.73333688154986 0.00163023168011133 no 68 0.00313480848636246 88 2888790 SGTC_2836 9010338 19.48 µM 2.70203903561955 0.00181667827429955 no 69 0.00344578354437531 121 2994051 SGTC_2685 mycophenolic acid 18.85 µM 2.69127589279339 0.00188514740447115 no 70 0.00355896517467701 52 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_165 k038-0023 64.381 µM 2.68272004797428 0.00194123899962183 no 71 0.00365130461210789 174 46368543 SGTC_1185 1319-0113 81.3 µM 2.6766136890534 0.00198219446652794 no 72 0.00371851647475296 64 4672763 SGTC_3187 9109394 49.47 µM 2.6364944285163 0.00227136525649632 no 73 0.00418837879005511 115 17098090 SGTC_1266 0828-0227 32.9 µM 2.61728365478381 0.00242292988306209 no 74 0.00443163267974276 100 3913820 SGTC_2737 bleomycin 30.5 nM 2.5597244055297 0.00293338672590422 no 75 0.00523775997491247 189 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2532 xanthone 78.9 µM 2.55246059598707 0.00300426354954993 no 76 0.00534825040332359 115 7020 An insecticide. SGTC_2452 5863136 48.41 µM 2.55226128244247 0.00300622992341359 no 77 0.00535131117626614 107 2184096 SGTC_2110 5483698 200 µM 2.55194960097507 0.00300930721352851 no 78 0.00535610065760131 104 2848765 YHR062C RPP1 SGTC_3285 9112818 20.8695 µM 2.55133967167444 0.00301533737296372 no 79 0.00536548421952579 106 17017947 YPR165W RHO1 SGTC_2119 5528445 120.635 µM 2.54787174551685 0.00304983093023881 no 80 0.00541911545413653 113 791935 SGTC_1030 k029-0042 36.7 µM 2.54592375052255 0.00306936207334876 no 81 0.00544944960531486 141 6080581 SGTC_3111 9122088 49.47 µM 2.53998699064288 0.00312958236769039 no 82 0.00554282961330391 44 16876704 SGTC_1770 st043884 66.3 µM 2.53611986789862 0.00316937896396681 no 83 0.00560441799754429 98 670149 SGTC_3105 9121040 49.47 µM 2.5339478751452 0.00319193015976143 no 84 0.00563927536477761 26 41448907 SGTC_2161 5662504 8.5105 µM 2.51200629795348 0.00342797152973079 no 85 0.00600234731276151 105 2859334 SGTC_266 formosanin C 406 nM 2.49400443139174 0.00363321726217978 no 86 0.00631554837598944 183 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1003 4049-0218 100 µM 2.48554043721375 0.00373347634686442 no 87 0.00646774451304056 145 295161 SGTC_1264 0783-0040 158 µM 2.46363647238936 0.00400455214854775 no 88 0.00687677627837797 128 2855798 SGTC_683 panaxydol 45 µM 2.46092997901919 0.00403924188154897 no 89 0.00692887043507186 120 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2876 9059903 25.97 µM 2.44770403030939 0.00421266115161264 no 90 0.0071884850009332 102 6916095 SGTC_2939 9044578 71.43 µM 2.44492232819631 0.00424997156324703 no 91 0.00724416702006754 155 2653634 SGTC_807 1315-0151 48 µM 2.44199498602343 0.00428955424789319 no 92 0.00730317474221151 143 4011080 SGTC_1103 duloxetine 36.1 µM 2.42843834046418 0.00447719345326622 no 93 0.00758200167452997 157 60835 A selective serotonin reuptake inhibitor. SGTC_675 1309-0189 238 µM 2.40422096920158 0.00483070506656779 no 94 0.0081034867605696 107 4246530 SGTC_3201 9113999 49.47 µM 2.40416035841049 0.00483162019089911 no 95 0.00810483051571435 148 16649224 SGTC_713 1488-1073 324 µM 2.3887265926352 0.00506973626370296 no 96 0.00845343947899246 91 3312542 SGTC_2191 5911152 200 µM 2.37974661109097 0.00521304007818656 no 97 0.00866227317579586 122 2875902 SGTC_1055 3448-0672 86 µM 2.37690570584444 0.00525912019614797 no 98 0.0087292752383819 149 748378 SGTC_1029 k015-0030 64.7 µM 2.33905572583235 0.0059085502794879 no 99 0.00966627481964313 159 2208316 SGTC_2691 st077356 60.2 µM 2.32324703992623 0.00620021440720089 no 100 0.0100829425373513 164 2839272 SGTC_380 3970-0968 6 µM 2.31797955901538 0.00630019147419664 no 101 0.0102252160023475 137 2891601 SGTC_1017 4239-0030 168 µM 2.31673215764726 0.00632407521231003 no 102 0.0102591633397508 168 1149593 SGTC_3081 9117243 49.47 µM 2.30703801188721 0.00651243502399989 no 103 0.0105263505592727 127 45595589 SGTC_1983 st071813 46.9 µM 2.30475451367527 0.00655751964583817 no 104 0.0105901629553269 133 11838595 SGTC_2863 9028737 58.44 µM 2.29386437977315 0.00677634914753206 no 105 0.0108991450087154 78 6460917 SGTC_2995 9067767 71.4286 µM 2.29070638932385 0.00684100191299904 no 106 0.0109902004224337 123 11673567 SGTC_343 4130-2827 29.8 µM 2.27397462058606 0.00719271950529811 no 107 0.0114837562526878 169 1118244 SGTC_1205 4161-2785 76 µM 2.27354132255001 0.00720203591673362 no 108 0.011496789448659 161 3498106 SGTC_2368 9071271 200 µM 2.26751025385326 0.00733282028429485 no 109 0.0116795366146563 183 27209959 SGTC_672 1441-0018 53.7 µM 2.26376185409295 0.0074151556294227 no 110 0.0117943829268944 137 251141 SGTC_1597 7-benzyloxygramine 47.5 µM 2.24969827933982 0.00773137571063091 no 111 0.0122340524149501 357 260807 SGTC_3088 9117578 49.47 µM 2.23707553941253 0.0080252435811417 no 112 0.0126407016768511 114 678341 SGTC_2787 5284540 71.43 µM 2.23418423499306 0.00809392185124235 no 113 0.0127354766519441 175 736958 SGTC_2529 gangaleoidin 93.61 µM 2.21802509791973 0.00848734738571601 no 114 0.0132765606008702 127 4565183 SGTC_1005 4092-0690 4.4 µM 2.21664419243389 0.00852173389235748 no 115 0.0133237075841539 159 1529343 SGTC_2176 5809774 33.9695 µM 2.21195190425683 0.00863949363753256 no 116 0.0134849941590064 142 2870539 SGTC_2130 NSC 7 2.4545 µM 2.17189569556852 0.00970422457562503 no 117 0.0149317656153014 216 21448 SGTC_154 3389-1638 511.116 µM 2.17064726135714 0.00973917527249803 no 118 0.0149789233106462 180 5238686 SGTC_665 3914-0008 307 µM 2.16525531447812 0.0098913923786958 no 119 0.0151840691948353 181 1069549 SGTC_1116 jasmonic acid  1.58368 µM 2.16504246064984 0.00989744372583937 no 120 0.0151922168672974 183 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_303 1348-1668 34.2 µM 2.16170313821045 0.00999280332270105 no 121 0.0153205327997294 137 5380509 SGTC_1673 st016611 27.3 µM 2.15617555517294 0.0101524150721606 no 122 0.0155349797761165 235 5226799 SGTC_2146 5545642 200 µM 2.15374864303231 0.0102231931109276 no 123 0.0156299445993256 135 825326 SGTC_1193 1488-0126 41.5 µM 2.15035676227368 0.0103228342229718 no 124 0.0157635028386898 193 1384710 SGTC_521 r062-0005 13.8 µM 2.15013005884944 0.0103295240310796 no 125 0.0157724642773094 166 2832033 SGTC_2810 7959871 45.46 µM 2.14627863146504 0.0104437550488715 no 126 0.0159253776935747 234 2974535 SGTC_155 k072-0202 43.6 µM 2.14567475872041 0.0104617650368372 no 127 0.0159494681803192 154 5857737 SGTC_696 1560-0013 611 µM 2.14463845085912 0.010492735117141 no 128 0.0159908827498728 180 1650269 SGTC_805 3852-0218 479 µM 2.13970171821623 0.0106413687334531 no 129 0.0161894400568697 230 6615355 SGTC_547 1120-0019 610 nM 2.13812657745685 0.0106891769053776 no 130 0.0162532356993768 206 3676939 SGTC_2137 5261020 140 µM 2.11631206114221 0.0113707684533257 no 131 0.0171591378113081 196 763655 SGTC_121 0557-0495 61.343 µM 2.09337457166304 0.0121278718935801 no 132 0.0181578652594565 321 3104427 SGTC_1402 3909-7673 35.9 µM 2.08954117055347 0.0122585739723493 no 133 0.0183295179553872 190 5328014 SGTC_3045 9092950 49.47 µM 2.06567681798482 0.0131000118137242 no 134 0.0194295028147029 203 44120432 SGTC_1263 0774-1208 64.8 µM 2.05987196196577 0.0133120789630328 no 135 0.0197053913801582 278 906585 SGTC_833 3852-0053 558 µM 2.05729785597948 0.013407063004138 no 136 0.0198287917378359 211 3123681 SGTC_1654 st012436 41.8 µM 2.05651001004415 0.0134362510969257 no 137 0.0198666912110543 159 4323132 SGTC_1777 st045864 34.765 µM 2.05449674681422 0.0135110877722427 no 138 0.0199638189612354 183 4691462 SGTC_2639 lactacystin 53 µM 2.05229135402159 0.0135934789485966 no 139 0.0200706778817637 215 3870 A proteasome inhibitor. SGTC_1831 st055328 12 µM 2.05139439572056 0.0136271122078371 no 140 0.0201142771931642 210 1103068 SGTC_14 0354-0009 295 µM 2.04952348814169 0.0136974968260036 no 141 0.0202054767398276 205 1713507 SGTC_2263 7948595 193.29 µM 2.0405681207916 0.0140387629876377 no 142 0.0206468867910013 146 2971371 SGTC_2507 purpurin 79.67 µM 2.03547025894934 0.0142362835847569 no 143 0.0209017890711479 246 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3266 9136860 49.47 µM 2.0348422598555 0.0142607807282785 no 144 0.0209333736737329 231 4871271 YPR165W RHO1 SGTC_1878 temozolomide 1 mM 2.0327140907901 0.0143440670683461 no 145 0.0210407084307335 166 5394 DNA alkylating agent. SGTC_1630 st005209 31.3 µM 2.02475848365343 0.0146591315164043 no 146 0.0214460850184267 249 3367314 SGTC_2783 7738165 71.43 µM 2.02343391743775 0.0147121621277727 no 147 0.0215142151297717 179 17201110 SGTC_2131 toluylene red 5.2905 µM 2.0107543253847 0.0152282106182349 no 148 0.0221757063630734 241 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2874 9043904 71.43 µM 2.01067563918487 0.0152314610141593 no 149 0.0221798643950764 152 4463428 SGTC_92 0063-0024 660.874 µM 2.00961686214343 0.0152752553238514 no 150 0.0222358775975183 229 3594437 SGTC_454 lyso-paf C-16 6.67 µM 2.00848851350617 0.015322046331606 no 151 0.0222957027233143 222 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_119 0121-0043 24.815 µM 2.00339427533407 0.0155348324814649 no 152 0.0225674927227954 414 1092378 SGTC_464 bw-b 70c 158 µM 1.99442436343913 0.0159156724210833 no 153 0.0230528490948083 257 5353454 SGTC_2688 kanamycin b 96.69 µM 1.98824946540376 0.0161824710318169 no 154 0.0233920533584434 802 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2477 5967686 25.23 µM 1.97044075538359 0.0169734913621525 no 155 0.024393939289557 232 776118 SGTC_796 1234-0020 70.7 µM 1.9690995779856 0.0170343794234313 no 156 0.0244708286560772 232 46495034 SGTC_1617 st002906 78 µM 1.96843976677662 0.017064402623965 no 157 0.0245087300638057 242 5150859 SGTC_1920 st075728 45.7 µM 1.96829087668712 0.0170711837781986 no 158 0.0245172895385698 230 3400306 SGTC_2651 TUB2.036 5 µM 1.96758515174323 0.0171033571479425 no 159 0.0245578947766971 449 15992207 YFL037W TUB2 SGTC_2582 agaric acid 100 µM 1.96481258643505 0.0172302581162063 no 160 0.0247179664483857 677 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2552 juarezic acid 87.02 µM 1.95879613428722 0.0175084016277133 no 161 0.0250683332496957 273 1549512 SGTC_2086 5274770 176.623 µM 1.95282514428379 0.0177882242927223 no 162 0.0254201590113273 233 689278 SGTC_1342 1486-1464 234 µM 1.95157846873236 0.0178471271162424 no 163 0.0254941358039422 224 3253938 SGTC_732 3970-1727 52.7 µM 1.94999622476068 0.0179221243498323 no 164 0.0255882845067447 189 1275699 SGTC_2062 5245942 200 µM 1.93994446134187 0.0184048751278692 no 165 0.0261932199382118 250 1376160 SGTC_853 0419-0306 21 µM 1.93645746214153 0.018574910899149 no 166 0.0264058487965342 210 762713 SGTC_1714 st033236 13.627 µM 1.93569222080278 0.0186124046273088 no 167 0.0264527038982544 241 2916566 SGTC_1223 0764-0573 147 µM 1.92026824342248 0.0193819654340606 no 168 0.0274120127337246 280 1609797 SGTC_189 3970-0742 2.116 µM 1.91623544262448 0.0195875794144608 no 169 0.0276675669583767 184 2891807 SGTC_237 nikkomycin 200 µM 1.91528502346455 0.0196363057334854 no 170 0.0277280822471619 253 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1437 4092-1038 11.6 µM 1.89451642400302 0.0207270526408066 no 171 0.0290782482217734 247 3977136 SGTC_505 gw-5074 63.9 µM 1.8916121840769 0.0208835949727427 no 172 0.0292713356605403 273 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1891 st059073 26.2 µM 1.89067309218795 0.0209344269025323 no 173 0.0293339982528255 264 688754 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.8818626749954 0.0214164447600617 no 174 0.0299273317009205 255 6708760 SGTC_986 1493-0483 84 µM 1.88038303280986 0.0214983092282585 no 175 0.0300279471357513 219 40079 SGTC_2598 perillyl alcohol 100 µM 1.87260100691713 0.0219332332540147 no 176 0.0305617510977164 286 10819 An apoptosis inducer. SGTC_1097 itavastatin 7.23 µM 1.86779152005088 0.0222057241805549 no 177 0.0308955679575794 279 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3245 9134821 49.47 µM 1.86591996779447 0.0223125300220522 no 178 0.0310262817437208 269 17014901 SGTC_391 gliotoxin 8.33 µM 1.85039792162975 0.023215156306161 no 179 0.0321281091765912 305 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1916 st067606 49.2 µM 1.84009709218389 0.0238309759565204 no 180 0.0328769920680296 338 19590279 SGTC_912 3474-0017 2.18 µM 1.83404320418098 0.0241992640797086 no 181 0.0333237905717701 277 3360550 SGTC_2512 diallyl trisulfide 49.23 µM 1.8321417742757 0.0243159194551271 no 182 0.0334651504899416 193 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1712 st032288 53.4 µM 1.82800073877968 0.024571612434425 no 183 0.0337747203849548 498 2883011 SGTC_1840 st055363 71 µM 1.8216547909208 0.0249678262562443 no 184 0.0342536908550663 241 676033 SGTC_1106 tegaserod maleate 11.7 µM 1.8157634378199 0.025340438406041 no 185 0.0347033340470455 306 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2034 5197015 53.07 µM 1.81478273771275 0.0254029150717777 no 186 0.0347786521169992 267 780676 SGTC_2555 cholic acid 100 µM 1.80695755719328 0.0259060640354411 no 187 0.0353844485565381 255 6708657 Influences liver metabolism. SGTC_1360 1598-0022 39.8 µM 1.80522352692385 0.0260186813426785 no 188 0.0355198553917378 359 761525 SGTC_1129 3453-1384 223 µM 1.7912327096745 0.0269423852952726 no 189 0.0366279796237395 340 1084452 SGTC_2417 cerulenin 830 nM 1.78636799927902 0.0272699110546537 no 190 0.0370198467217141 255 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2828 7998861 71.43 µM 1.78567222118922 0.0273170259865764 no 191 0.0370761728414977 232 2988188 SGTC_1049 3226-0134 66 µM 1.78373449731515 0.0274485978044204 no 192 0.0372334088744305 328 5702385 SGTC_268 camptothecin 39.6153 µM 1.77974600569764 0.0277210806973261 no 193 0.0375587688361564 414 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1721 st082152 9.2685 µM 1.76588483953304 0.0286856243868013 no 194 0.0387075855740047 276 5296051 SGTC_1153 4055-0057 267 µM 1.76389393627534 0.0288264289793347 no 195 0.0388749189780123 319 882706 SGTC_1151 3909-8316 15.3 µM 1.75862491888693 0.0292018495381616 no 196 0.0393206188011269 300 800431 SGTC_1335 1486-0900 202 µM 1.75734734484273 0.0292934866569163 no 197 0.0394293112440829 343 X1335 SGTC_1195 1502-0147 41.1 µM 1.75065383715238 0.0297775064902397 no 198 0.0400027778124089 335 817940 SGTC_1075 aripiprazole 15.2 µM 1.7452247945373 0.0301749472193846 no 199 0.0404728734453574 370 60795 An atypical antipschotic. YIL048W NEO1 SGTC_799 1310-0557 151 µM 1.74455494292952 0.0302242880030622 no 200 0.0405311848319686 327 5354492 SGTC_3309 9129340 25.759 µM 1.74151279842657 0.0304492123712912 no 201 0.0407968659246604 304 17158987 SGTC_3119 9125183 49.47 µM 1.74128701031065 0.0304659614045782 no 202 0.0408166409872152 188 22695334 SGTC_1682 st012968 530 nM 1.73961246113667 0.0305904183397019 no 203 0.0409635448415659 258 24207270 SGTC_1474 0330-0125 5.35 µM 1.73544846395607 0.0309017239447546 no 204 0.0413307011345872 298 X1474 SGTC_285 1486-1325 46 µM 1.7351219522823 0.0309262448303588 no 205 0.0413596033948354 328 22310230 SGTC_2782 7736369 71.43 µM 1.73313089816839 0.0310761208721395 no 206 0.0415362028233223 353 2950836 YOL077C BRX1 SGTC_839 0122-0028 230 µM 1.73302466950049 0.0310841340626297 no 207 0.0415456420700416 390 759448 SGTC_2709 st078560 56 µM 1.7280054453542 0.0314647043692091 no 208 0.0419936240582934 287 17250903 SGTC_2069 5228469 200 µM 1.72468369316166 0.0317186800215948 no 209 0.0422922456770422 293 2835210 SGTC_740 k014-0057 261 µM 1.72270132006192 0.031871054404886 no 210 0.0424712757509011 347 4012779 SGTC_953 1188-0045 9.7 µM 1.71564781508256 0.0324181301180233 no 211 0.0431132606977988 349 6144426 SGTC_1941 st076221 61.8 µM 1.71522300194612 0.0324513248425933 no 212 0.0431521745993945 398 2828568 SGTC_3199 9111318 49.47 µM 1.7117349982497 0.0327249376969196 no 213 0.0434727579000708 321 8548020 SGTC_611 3453-1652 23.7 µM 1.70559727629907 0.0332110224219789 no 214 0.0440415434251228 361 1560575 SGTC_3332 9141069 11.198 µM 1.70364168184799 0.0333671418914609 no 215 0.044224024684517 274 17332883 SGTC_3060 1327-0027 12.5 µM 1.7028601009611 0.0334297060337481 no 216 0.0442971261462024 298 16000455 YPR107C YTH1 SGTC_2327 6189656 200 µM 1.69991585624591 0.0336662553236698 no 217 0.0445733769670007 298 5349088 SGTC_528 3492-0019 172 µM 1.69354676415677 0.0341826813485628 no 218 0.0451757207089474 585 2869262 SGTC_1432 4049-0298 68.4 µM 1.68963597406679 0.0345029951488927 no 219 0.0455488095886457 286 741646 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.68534992825965 0.0348568722524065 no 220 0.0459605390615434 312 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1877 wortmannin 25 µM 1.68424919978682 0.0349482331320419 no 221 0.0460667592577081 412 312145 A covalent inhibitor of PI 3-kinase. SGTC_1293 1000-1278 195 µM 1.68212729603805 0.0351249065893684 no 222 0.0462720791947684 355 678847 SGTC_439 amiodarone 34.4 µM 1.67759477088214 0.0355047476374067 no 223 0.0467131171655193 408 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.67287645430459 0.0359037296423731 no 224 0.0471758099591759 350 2333 A French combination drug. SGTC_2406 ethylparaben 405.7 µM 1.67030916347398 0.0361223587598699 no 225 0.0474291055552198 308 8434 A possible steroid mimic. SGTC_820 1582-0060 59.9 µM 1.6659568944657 0.0364954855032038 no 226 0.0478610001529771 370 3848840 SGTC_1082 camptothecin 424.86 nM 1.66354322853896 0.0367037685704717 no 227 0.0481018725969644 338 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1581 himbacine 57.9 µM 1.66099845169287 0.0369244174974119 no 228 0.04835687883595 378 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2121 5257820 149.641 µM 1.6607191850686 0.0369486976511833 no 229 0.0483849292230779 355 791256 SGTC_2687 chenodiol 100 µM 1.65693239527837 0.0372792211044735 no 230 0.0487665719611901 318 5702181 A cholesterol synthesis inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 1.65085910223924 0.0378143586037236 no 231 0.0493836742581224 334 16667744 Haematoxylin. SGTC_2526 patulin 37.61 µM 1.63617298813066 0.039134338078578 no 232 0.0509016940056405 452 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2673 kobusone 100 µM 1.63476112752835 0.0392631875976539 no 233 0.0510495663031864 283 6710676 An epoxy ketone and protein crosslinker. SGTC_582 0987-0078 156 µM 1.63306566697711 0.0394183750816023 no 234 0.0512275932395046 495 1625765 SGTC_1761 st044296 37 µM 1.62792459973697 0.0398919958831936 no 235 0.0517704372876242 363 1826700 SGTC_2314 7727897 200 µM 1.62774473386821 0.0399086494050416 no 236 0.0517895117428539 344 900724 SGTC_1986 st071812 45 µM 1.62262270512812 0.0403852670588474 no 237 0.0523350418947712 303 11838594 SGTC_1027 k015-0025 8.67 µM 1.61962155510147 0.0406666724360307 no 238 0.052656798197058 374 3598955 SGTC_1745 st081495 74 µM 1.61532407546267 0.0410723980471422 no 239 0.0531202662957901 444 13842402 YBL026W LSM2 SGTC_1506 4226-2149 212 µM 1.61200369511462 0.0413881183609019 no 240 0.0534805678222057 418 991114 SGTC_3280 9140961 49.47 µM 1.59676387194081 0.0428625252722248 no 241 0.0551591759989897 321 4901226 SGTC_2534 helenine 20.12 µM 1.59099020491456 0.0434320797098613 no 242 0.0558058900855192 318 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1327 1436-0082 2.18 µM 1.58868158916683 0.0436615206793072 no 243 0.0560661487752191 355 15992205 SGTC_1126 isoteolin 1.0172 µM 1.5855383887966 0.0439754778248019 no 244 0.0564220309902792 387 133323 SGTC_1423 4048-0112 5.59 µM 1.58380886646971 0.0441490053642368 no 245 0.0566186104922816 380 X1423 SGTC_1743 st037606 46.3785 µM 1.58309627668677 0.0442206617670118 no 246 0.0566997610681939 386 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_933 2914-0560 114 µM 1.57802219365132 0.0447336143212192 no 247 0.0572802556288233 428 463887 SGTC_2950 9072895 21.46 µM 1.57745817810795 0.0447909268688707 no 248 0.0573450689560799 432 17332245 SGTC_856 0433-0016 11.3 µM 1.57638679233745 0.0448999587605356 no 249 0.0574683451698177 397 3911780 SGTC_1788 fluconazole 20 µM 1.57469064983918 0.0450730071597804 no 250 0.0576639335493878 383 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2340 7987427 183.45 µM 1.57434342909387 0.045108498346261 no 251 0.0577040373156546 370 2239331 SGTC_997 3996-0078 137 µM 1.5683305921694 0.0457266749762705 no 252 0.0584019999923614 403 735687 SGTC_2558 carylophyllene oxide 100 µM 1.56810871300223 0.0457496158857631 no 253 0.0584278817393834 402 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1196 1588-0294 184 µM 1.5654813224317 0.0460219754783543 no 254 0.0587350467280569 354 6144269 SGTC_3256 9138902 49.47 µM 1.56496305924211 0.0460758529881011 no 255 0.058795785633003 317 17228773 SGTC_991 3996-0057 64.7 µM 1.56169017228955 0.0464172664106759 no 256 0.0591804975520609 378 715343 SGTC_2887 9044784 58.44 µM 1.55820472653418 0.0467830828951224 no 257 0.0595923624556935 397 6465546 SGTC_1911 st060208 74.3 µM 1.55735214484758 0.0468729171276068 no 258 0.059693450686443 423 688783 SGTC_61 0978-8327 98.565 µM 1.55533584096592 0.0470859201847855 no 259 0.0599330528146098 408 6150059 YHR072W ERG7 SGTC_3247 9135149 49.47 µM 1.54930954396917 0.0477271691731243 no 260 0.060653663288748 327 8934436 YOR116C RPO31 SGTC_706 4262-0057 46.9 µM 1.54914910309967 0.0477443365373765 no 261 0.0606729406454687 398 883298 SGTC_2778 tioconazole 65.09 nM 1.54581795806872 0.0481018914243859 no 262 0.0610742693686075 450 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_881 0833-0569 170 µM 1.53778549578769 0.0489728869253225 no 263 0.0620505355554533 420 5418700 SGTC_829 1635-0120 117 µM 1.53755887682895 0.0489976417867629 no 264 0.062078254430884 446 285054 SGTC_2588 indole-3-carbinol 100 µM 1.53449167950006 0.0493336732056699 no 265 0.0624543693277576 454 3712 Induces cell cycle arrest. SGTC_2696 st077691 74.316 µM 1.5319467426296 0.0496138820799486 no 266 0.0627677887748805 376 757133 SGTC_1965 Pectolinarigenin 58.4 µM 1.52872328410525 0.0499706206844781 no 267 0.0631665287684239 385 5320438 An anti-inflammatory. SGTC_355 1311-2252 105 µM 1.52709278966403 0.0501518441488447 no 268 0.063368969814973 421 5338538 SGTC_2517 totarol 10 µM 1.52660045799172 0.0502066678730585 no 269 0.0634301965409994 374 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.52559781870869 0.050318464740511 no 270 0.0635550278524688 495 368090 SGTC_2903 5923464 63.88 µM 1.52451802709098 0.050439086080801 no 271 0.063689678557065 362 2876576 SGTC_2004 4023728 41.89 µM 1.51825367391052 0.0511434161523811 no 272 0.0644752306564592 436 360084 YDR527W RBA50 SGTC_2654 protoveratrine a 100 µM 1.51682453787353 0.0513051918601258 no 273 0.0646554950235505 387 5702278 A heart drug and vasodilator. SGTC_25 0118-0223 35.662 µM 1.51602213091314 0.0513962012185935 no 274 0.0647568782388825 408 5333628 SGTC_2480 5767542 37.17 µM 1.51526524737216 0.0514821649308091 no 275 0.0648526227211848 382 2867358 SGTC_2850 9015429 58.44 µM 1.51323449167926 0.0517133748108704 no 276 0.0651100529225135 382 6457570 SGTC_1686 st019653 115.5 µM 1.51250424785949 0.0517967175639305 no 277 0.0652028164099955 377 97252 SGTC_659 k018-0002 107 µM 1.50577144156979 0.0525701719074517 no 278 0.0660629284676608 422 6797879 YHR007C ERG11 SGTC_63 0099-0242 26.702 µM 1.50323741300473 0.0528636405850315 no 279 0.0663889164942795 489 3898502 YLR359W ADE13 SGTC_1355 1499-0035 1.68 µM 1.49976243795435 0.0532681925782529 no 280 0.0668379752162587 421 1548538 SGTC_660 4031-1742 102 µM 1.49865395337897 0.0533977558942439 no 281 0.0669817140556718 474 6738706 SGTC_682 0kpi-0099 17 µM 1.49687723560861 0.0536059453014649 no 282 0.0672126022841873 477 1714895 YML126C ERG13 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.49669607130063 0.0536272095597939 no 283 0.0672361794978749 327 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2387 9077560 195.08 µM 1.48799408548989 0.0546565016791503 no 284 0.0683762267100103 425 5303272 SGTC_1779 st039427 55 µM 1.48402615092237 0.0551309944954032 no 285 0.0689009915308585 510 1124498 SGTC_3117 9124945 49.47 µM 1.48320531579441 0.055229556484609 no 286 0.0690099346549926 359 17592065 SGTC_1302 1159-0335 255 µM 1.47879653770051 0.0557613250169192 no 287 0.0695973507475306 413 649284 SGTC_595 3909-8003 73.7 µM 1.45872195153713 0.0582338902220539 no 288 0.072320825870578 440 699517 SGTC_920 mycophenolic acid 780.421 nM 1.45263943656631 0.0589998310634621 no 289 0.0731619452390188 452 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.44990711393095 0.0593464612958246 no 290 0.0735422116390538 466 688751 SGTC_2638 epoxomicin 18 µM 1.44929787705531 0.0594239680906777 no 291 0.0736272068520146 474 9915668 A protesome inhibitor. SGTC_2818 7996756 12.99 µM 1.44905827280735 0.0594544721489587 no 292 0.073660654836107 340 2241621 SGTC_233 rapamycin 362 pM 1.44604628226687 0.0598389769867748 no 293 0.0740821104770943 436 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_41 0478-0632 82.643 µM 1.44295855871353 0.0602351689589255 no 294 0.0745160727759352 534 3750424 SGTC_1105 epirubicin 18.1 µM 1.44262997654631 0.0602774505925795 no 295 0.0745623671645477 444 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3013 9080133 71.4286 µM 1.43990199630218 0.0606293820536714 no 296 0.0749475641122882 494 17050193 SGTC_1724 st037281 8.293 µM 1.43836685722575 0.0608281329500225 no 297 0.075164995617482 489 574124 YDL195W SEC31 SGTC_449 xestospongin c 11.1929 µM 1.43709450949449 0.0609932466652266 no 298 0.0753455705553771 485 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_510 ag-490 170 µM 1.43706301081534 0.0609973387170753 no 299 0.0753500451215319 471 5328779 SGTC_2455 5377712 9.75 µM 1.43641866727615 0.061081093688048 no 300 0.0754416222357546 410 2243908 SGTC_1006 4099-6547 255 µM 1.43286188630975 0.061545040299805 no 301 0.0759486556232909 460 3146833 SGTC_3298 9116858 71.43 µM 1.42896355852407 0.0620566945365456 no 302 0.0765073538529411 467 2506942 SGTC_1834 st055981 52.8 µM 1.42692977044043 0.062324942782883 no 303 0.0768000693658799 466 471719 YDL150W RPC53 SGTC_229 benomyl 22.8748 µM 1.42279578744639 0.0628729844583965 no 304 0.0773976814516984 495 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2988 9073640 71.4286 µM 1.42267385694658 0.0628892055933542 no 305 0.0774153613002132 438 9102229 SGTC_2796 7949634 45.45 µM 1.42174013489826 0.0630135322639313 no 306 0.0775508521265156 453 2971588 SGTC_2975 9084847 53.72 µM 1.4185870800376 0.063434782022849 no 307 0.0780097173842988 474 27211724 SGTC_2294 7971431 200 µM 1.41800639851766 0.0635125998328502 no 308 0.0780944483484108 391 5741572 SGTC_3168 9103419 49.47 µM 1.41586298282372 0.0638004848454597 no 309 0.0784078124113885 329 16649256 SGTC_3140 9094243 49.47 µM 1.4153117592915 0.0638746842443972 no 310 0.0784885543469944 468 19291112 SGTC_187 1488-2104 32.728 µM 1.41503447999894 0.0639120337693686 no 311 0.0785291933904231 483 2852859 SGTC_427 1354-0053 47.3 µM 1.41498309112707 0.0639189577163812 no 312 0.0785367268786906 474 6813657 SGTC_550 4123-0385 25.7 µM 1.41252411607042 0.0642509532211156 no 313 0.0788978474846359 458 5731123 SGTC_2011 4012611 177 µM 1.41029266379056 0.0645533885492385 no 314 0.0792266419236625 481 2049887 SGTC_2739 tacrine 100.86 µM 1.40992815880816 0.0646028958906272 no 315 0.0792804485166945 423 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2377 9073351 62.6 µM 1.4070269228945 0.0649979961104464 no 316 0.0797097027760882 466 7337946 YHR072W ERG7 SGTC_1455 4262-0120 131 µM 1.40490967106271 0.0652875126104844 no 317 0.0800240702007789 481 1529587 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.40450591542592 0.0653428362311712 no 318 0.0800841257117129 497 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1554 st069299 38.7 µM 1.40425045678536 0.0653778586007028 no 319 0.0801221407925342 483 24207999 SGTC_656 4090-1979 187 µM 1.40340231580244 0.0654942398016077 no 320 0.0802484514123498 522 22330961 SGTC_2471 5466956 24.79 µM 1.40331068792753 0.0655068225127137 no 321 0.0802621062281893 436 724419 SGTC_1158 4092-0494 91.8 µM 1.40096664425116 0.0658293539184696 no 322 0.0806120239520844 493 1148199 SGTC_301 4119-0100 24.5 µM 1.40041188488547 0.0659058664959502 no 323 0.0806950065328591 536 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_90 0870-0863 4.608 µM 1.39953451248758 0.0660270146215864 no 324 0.0808263782116249 527 1738164 SGTC_1007 4101-0031 70 µM 1.39771443845517 0.0662788817227485 no 325 0.0810994183587584 505 1146276 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.39708792887098 0.0663657518622228 no 326 0.0811935656534375 419 15053 SGTC_32 0928-0142 34.1 µM 1.39210258767703 0.0670601510830164 no 327 0.0819456673896178 430 2244242 SGTC_637 1181-0519 7.26 µM 1.39025852847075 0.0673184257385253 no 328 0.082225193145411 605 6252091 YGR060W ERG25 SGTC_172 1112-0046 2.638 µM 1.38618043934836 0.0678923234190401 no 329 0.0828459064120379 431 2802135 YIL048W NEO1 SGTC_1070 indatraline 8.81 µM 1.38069517329574 0.0686701987298814 no 330 0.0836863530039259 510 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2906 7926292 26.41 µM 1.37699851577978 0.0691982930122547 no 331 0.0842563533601985 499 2966319 SGTC_390 dec-rvkr-cmk 16.7 µM 1.37497694201118 0.0694884099701671 no 332 0.0845692966790805 520 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2185 6113692 200 µM 1.37445073253154 0.0695640799539456 no 333 0.0846508977016673 450 874150 SGTC_2213 7173844 200 µM 1.37126608881962 0.0700233927920247 no 334 0.0851460114001749 506 892728 SGTC_2192 5915882 198.485 µM 1.36953889263015 0.0702734757804422 no 335 0.0854154430542913 434 2876149 SGTC_552 k242-0005 476 µM 1.36929621329605 0.0703086686023782 no 336 0.0854533506008874 471 4088318 SGTC_1450 4112-4260 37.6 µM 1.36907850168354 0.0703402521920456 no 337 0.0854873688040053 509 1633175 SGTC_361 000s-0510 1.45 µM 1.36806407913578 0.0704875591057324 no 338 0.0856460096198402 507 660 SGTC_1572 epiandrosterone 68.9 µM 1.36019053856683 0.0716389715810716 no 339 0.086884817928288 544 441302 A steroid. SGTC_747 3448-8087 38.7 µM 1.35839048846273 0.0719042231319606 no 340 0.0871699053882588 530 5168703 SGTC_2239 6685329 187.64 µM 1.3560613640052 0.0722485548571748 no 341 0.087539822240366 518 805680 SGTC_945 3381-0768 11.3 µM 1.35331424730433 0.0726563040685608 no 342 0.0879776297649636 529 1126236 YIL048W NEO1 SGTC_2475 5812728 15.03 µM 1.35146050746218 0.0729324453712272 no 343 0.0882739812472552 534 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.34902320727209 0.0732967380380218 no 344 0.0886647560179801 589 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_318 1488-0629 67.2 µM 1.34758016173532 0.0735130788737307 no 345 0.0888967273828654 481 3662576 SGTC_2813 7971799 71.43 µM 1.34404114726612 0.0740457134866164 no 346 0.0894675407480081 475 2234054 SGTC_3055 9094636 49.47 µM 1.34382631484201 0.0740781412237322 no 347 0.0895022789788238 478 25236176 SGTC_1322 1348-1070 12 µM 1.34343389594545 0.0741374026386839 no 348 0.0895657586950149 468 6758089 SGTC_533 1222-0222 6.71 µM 1.33891158365578 0.074822958550169 no 349 0.0902997290936543 571 3982874 SGTC_2682 pyrogallin 40.03 µM 1.3367991420637 0.0751448448500813 no 350 0.0906441046645989 572 822798 An ATP competetive kinase inhibitor. SGTC_1809 st050081 57.6 µM 1.33324106017111 0.0756893981554172 no 351 0.0912263543850699 511 5036894 SGTC_3181 9108277 49.47 µM 1.33267722681033 0.0757759663273394 no 352 0.0913188748799455 499 17097298 SGTC_3211 9128781 49.47 µM 1.33147743038012 0.0759604280586751 no 353 0.0915159832518085 534 17194361 SGTC_575 k072-0246 11.9 µM 1.33136717856778 0.0759773957723881 no 354 0.0915341117601086 544 6796779 SGTC_864 0469-0573 172 µM 1.32992706694261 0.0761992935403008 no 355 0.0917711512041364 508 689425 SGTC_2055 5235184 200 µM 1.32979057367568 0.0762203504957771 no 356 0.0917936412884148 528 2836034 SGTC_1558 st069300 45.6 µM 1.3284974272224 0.0764200653025724 no 357 0.0920069164716336 426 24208000 SGTC_484 loperamide 105 µM 1.32796839042822 0.0765018849273256 no 358 0.0920942747783794 408 3955 An opioid-receptor agonist. SGTC_1971 st069429 63.5 µM 1.32444342087014 0.0770487508183805 no 359 0.0926779110036255 487 1246522 YGL099W LSG1 SGTC_2695 st077686 51.995 µM 1.32267886625962 0.0773236183113488 no 360 0.0929710972634676 490 2876092 SGTC_1547 harmine 94.2 µM 1.32155097686827 0.0774997012675929 no 361 0.0931588584636197 598 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_142 0335-0849 62.6745 µM 1.32025495852107 0.0777024078280756 no 362 0.0933749541338779 661 3889043 YPR107C YTH1 SGTC_2164 5685496 200 µM 1.31979661460206 0.0777741923612215 no 363 0.0934514661079117 564 759046 SGTC_313 3474-0040 5.03 µM 1.31447877078825 0.0786107418490003 no 364 0.0943425688073442 593 1043375 YIL048W NEO1 SGTC_1053 3366-3204 134 µM 1.30128720048978 0.0807153300831471 no 365 0.0965800833676734 578 3632071 YPR165W RHO1 SGTC_1393 3470-5649 58.2 µM 1.30106531334715 0.0807510903894589 no 366 0.096618049728585 437 4108395 SGTC_1378 2093-0007 380 nM 1.29907805499036 0.08107189923077 no 367 0.0969585716985014 552 3618014 SGTC_2629 bisabolol 100 µM 1.2954292349096 0.0816634417375718 no 368 0.0975860991796551 579 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_767 0929-0023 86 µM 1.29159709584142 0.0822882009560382 no 369 0.0982483551569933 646 1204563 SGTC_2734 clemastine 41.6 µM 1.29013194273429 0.0825280158692234 no 370 0.0985024254438865 382 26987 Clemastine is a selective histamine H1 antagonist. SGTC_522 1273-0010 11.6 µM 1.28934814542284 0.0826565229100426 no 371 0.0986385400535198 531 5705015 SGTC_3152 9099253 49.47 µM 1.28902432186168 0.0827096591582552 no 372 0.0986948155776411 657 25236131 SGTC_1277 0873-0036 22 µM 1.28844929985882 0.0828040779352959 no 373 0.0987948034095805 605 5965735 SGTC_2016 5121758 140 µM 1.28596311136234 0.0832132443168481 no 374 0.0992279680209109 602 2795203 SGTC_854 0422-0053 192 µM 1.28437766399751 0.0834749632138847 no 375 0.0995049221706146 545 3596728 SGTC_1312 1218-2183 165 µM 1.28042673206482 0.0841298573051 no 376 0.100197548709956 576 6744073 SGTC_3190 9110366 49.47 µM 1.27975976701922 0.0842407908143001 no 377 0.100314818802076 475 17123768 SGTC_96 0929-0093 37.281 µM 1.27849949420179 0.0844507063887156 no 378 0.100536681497449 521 6991579 SGTC_421 streptovitacin 30 mM 1.27694949967473 0.0847094169050101 no 379 0.100810038396539 603 91467 include heat shock SGTC_3234 9132280 49.47 µM 1.27662973994353 0.0847628620705272 no 380 0.100866498568959 586 17612295 SGTC_2234 tolnaftate 200 µM 1.27314359601363 0.085347183386597 no 381 0.101483545626049 485 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3249 9135183 49.47 µM 1.27096514632348 0.0857138476099853 no 382 0.101870524142679 603 4902779 SGTC_1242 0402-0103 60.1 µM 1.26786266385878 0.0862380736631779 no 383 0.102423499669839 529 432868 SGTC_1492 4158-0558 28.5 µM 1.26729463316851 0.0863343129058343 no 384 0.102524979403409 545 3967268 SGTC_504 lovastatin 124 µM 1.26456701996486 0.0867975608894145 no 385 0.103013290866431 496 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_838 0109-0203 71.4 µM 1.2573921279277 0.0880249840895022 no 386 0.104305839176535 589 759422 SGTC_3351 9150312 21.596 µM 1.25705749919606 0.0880825439707753 no 387 0.104366407740198 580 4904905 SGTC_2952 9073731 13.78 µM 1.25522656174057 0.0883979825759365 no 388 0.104698262874952 617 16457353 SGTC_2949 9072542 2.23 µM 1.25446933376253 0.0885286855228297 no 389 0.104835732662019 595 16457352 SGTC_2700 st077718 96.8 µM 1.25398886158684 0.0886116930696834 no 390 0.104923026988966 531 904970 SGTC_622 1348-1566 26.3 µM 1.25376909843633 0.0886496792051778 no 391 0.104962972072435 645 7340407 SGTC_1220 1838-0075 193 µM 1.25019375972007 0.0892693825466922 no 392 0.105614387916801 591 5529645 SGTC_2469 5655019 90.81 µM 1.24923015587735 0.0894369513728417 no 393 0.105790452655059 614 2788239 SGTC_2646 retinol 96.75 µM 1.24861084614542 0.0895447715602183 no 394 0.105903721685451 568 445354 A vitamin A analog and teratogen. SGTC_2564 betulinic acid 100 µM 1.24655754303855 0.089902937717398 no 395 0.106279888781976 633 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1165 k072-0275 30.3 µM 1.24407224922031 0.0903378807554028 no 396 0.106736486703289 559 6153523 YGL055W OLE1 SGTC_298 1391-0729 10 µM 1.23999565413786 0.0910546929135362 no 397 0.107488500788681 550 3237558 SGTC_2442 5158906 48.48 µM 1.23924087650613 0.0911878715722805 no 398 0.107628153392289 601 1893835 SGTC_841 0251-0215 91.2 µM 1.23886962209442 0.0912534314743318 no 399 0.107696892623537 650 3888614 SGTC_1508 1080-0625 72.9 µM 1.23646083846642 0.091679648317199 no 400 0.108143656924504 544 767111 SGTC_153 4077-0274 519.67 µM 1.23274765459189 0.0923395558999035 no 401 0.108834963171824 538 3121976 SGTC_125 0133-0007 11.75 µM 1.23196094291548 0.0924798205881778 no 402 0.10898183712313 626 26541 SGTC_606 k015-0008 38.6 µM 1.22957273086121 0.0929065861404338 no 403 0.109428573364433 644 1970475 SGTC_763 3453-1109 128 µM 1.22903445555782 0.0930029748979817 no 404 0.109529443908868 615 1560353 SGTC_1851 st056236 18.9 µM 1.2269744507145 0.0933725420077911 no 405 0.109916096928618 620 5393171 SGTC_2181 6316240 54.2555 µM 1.22680268250105 0.093403406343071 no 406 0.109948381183996 548 12779990 SGTC_599 1935-0052 86.5 µM 1.22530303310989 0.0936731924533186 no 407 0.110230533013747 631 9557311 SGTC_2909 7941780 10.49 µM 1.22267978133771 0.0941464967466563 no 408 0.110725333235536 617 1243215 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.22210220054548 0.0942509442419507 no 409 0.110834490533097 643 688801 SGTC_3277 9138724 49.47 µM 1.22209534177799 0.0942521850684531 no 410 0.110835787238217 485 15943418 SGTC_219 mitoxanthrone 164.414 µM 1.21749828176514 0.0950865567069219 no 411 0.111707344890681 610 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2133 5320837 200 µM 1.21737143578389 0.0951096562767696 no 412 0.111731462958313 560 2841355 SGTC_226 1,3-diallylurea 8.28947 mM 1.20940269689963 0.096569118749318 no 413 0.113254086524719 552 74537 YKL182W FAS1 SGTC_891 0929-0073 133 µM 1.20839583743257 0.0967546879552008 no 414 0.113447520084682 623 5603632 SGTC_2716 st080858 38.6235 µM 1.20749949721295 0.0969201081342551 no 415 0.113619919290048 612 5296050 SGTC_1274 0865-0114 173 µM 1.20181024745614 0.097974906601895 no 416 0.114718527133156 617 870624 SGTC_1783 st039459 87.517 µM 1.20080145308429 0.098162813904267 no 417 0.114914114040251 688 729761 SGTC_2754 granisetron 64.02 µM 1.20057396366555 0.0982052246297855 no 418 0.114958252862025 633 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2280 7785178 200 µM 1.20055489649574 0.0982087799211783 no 419 0.114961952932953 593 2954328 SGTC_1935 st074532 41.6 µM 1.20038837248834 0.0982398342301583 no 420 0.114994271273319 718 2829742 SGTC_20 0481-0013 4.944 µM 1.19714033368988 0.0988469853456261 no 421 0.115625930669221 607 182045 SGTC_1013 4112-3890 241 µM 1.19522475227696 0.0992063468610792 no 422 0.115999615095046 642 705171 SGTC_2291 7917025 104.35 µM 1.19366053445805 0.0995005006897151 no 423 0.116305392095001 640 2964612 SGTC_3123 9126162 49.47 µM 1.19040304287643 0.100115122562255 no 424 0.116944008829554 617 25239884 SGTC_1275 0867-0008 21.1 µM 1.18954172319241 0.100278098303958 no 425 0.117113281368563 633 3422836 SGTC_2947 9072639 7.68 µM 1.18944969166507 0.100295523614975 no 426 0.11713137830479 672 16488146 SGTC_2473 5854593 8.94 µM 1.1890460253889 0.100371980163629 no 427 0.117210778015326 603 2872951 SGTC_927 2425-1185 123 µM 1.18626078664653 0.100900678708147 no 428 0.117759663684052 610 730375 SGTC_1588 farnesol 29.9 µM 1.1819915807126 0.101715003016852 no 429 0.118604520773162 641 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_473 2-arachidonoylglycerol 10 µM 1.17930523088444 0.102229854012873 no 430 0.119138328048441 614 5282280 An endocannabinoid. SGTC_1568 digitonin 820 nM 1.17838651696361 0.102406363920789 no 431 0.119321275225857 691 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1999 st074831 12.5 µM 1.17770984154882 0.102536513308661 no 432 0.119456151035896 663 17112523 SGTC_2427 5545055 42.75 µM 1.17747697603348 0.102581329649253 no 433 0.119502590956585 693 5372858 SGTC_495 decylubiquinone 155 µM 1.17679807056466 0.102712070277306 no 434 0.119638056456742 616 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1726 st035556 14.5795 µM 1.17636769790384 0.102795012243958 no 435 0.119723986998372 690 5919439 SGTC_589 1227-0070 34.1 µM 1.17271946787705 0.103500059381323 no 436 0.120454160929823 649 2841384 SGTC_84 0443-0269 128.823 µM 1.17081867188926 0.103868789758759 no 437 0.120835835435022 672 6150058 SGTC_862 0452-0056 10.2 µM 1.1699883249343 0.104030165238756 no 438 0.121002833618394 635 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3329 9141233 27.5565 µM 1.16915158125195 0.104192967728763 no 439 0.121171282499877 609 4909101 YNL103W MET4 SGTC_2702 st077768 96.8 µM 1.1675797021992 0.104499302310905 no 440 0.121488170816901 589 6484119 SGTC_2804 7954240 19.48 µM 1.1675542081257 0.104504276077761 no 441 0.121493315178001 682 828705 SGTC_1100 amiodarone 5.07 µM 1.16600892554278 0.104806073357914 no 442 0.121805418397421 676 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2905 7799065 20.05 µM 1.1651933396115 0.104965613400051 no 443 0.121970370520002 616 1296806 SGTC_397 arbidol 50 µM 1.16198190087791 0.105595524823352 no 444 0.122621408422982 685 131410 A RNA synthesis inhibitor. SGTC_2031 5180455 200 µM 1.15925752224137 0.106132040604805 no 445 0.123175615373842 616 29949 SGTC_2324 6149169 200 µM 1.1586406281405 0.106253799410381 no 446 0.123301350480573 616 2888231 SGTC_580 1123-0028 41 µM 1.15577384371649 0.106820951776747 no 447 0.123886837235141 732 1677248 YPR107C YTH1 SGTC_160 3453-0671 289.699 µM 1.15561502059292 0.106852436401885 no 448 0.123919330661711 667 5322268 SGTC_1731 st035964 63 µM 1.15280741968247 0.107410112586522 no 449 0.124494719144377 640 6739575 SGTC_136 0097-0015 404.482 µM 1.14665079061329 0.108640346540332 no 450 0.125762988001875 708 4861337 SGTC_2984 9022109 38.96 µM 1.14613373461512 0.108744125478631 no 451 0.125869910584179 629 6459207 SGTC_1603 st002045 67.8 µM 1.14584502967112 0.108802102805023 no 452 0.125929639774287 674 5887985 SGTC_726 3448-4391 34.2 µM 1.14518901295091 0.108933925795482 no 453 0.126065434330305 713 1356692 SGTC_1764 st044502 93.5 µM 1.14030136353114 0.109919687771172 no 454 0.127080384974892 675 8407 SGTC_3258 9138477 49.47 µM 1.13612826673869 0.110766388293531 no 455 0.127951443244076 665 4970355 SGTC_491 tetrandrine 80.3 µM 1.13494530853901 0.111007252538056 no 456 0.128199117182039 628 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_792 4534-1957 155 µM 1.13479538861963 0.111037804765616 no 457 0.128230529414747 681 1717904 SGTC_2661 dactinomycin 12.96 µM 1.13324522903025 0.11135406539267 no 458 0.128555642680143 719 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_985 1493-0307 8.71 µM 1.12636531450986 0.112765473235929 no 459 0.130005461016739 623 3278274 SGTC_2556 citropten 84.59 µM 1.12441814479171 0.113167242424691 no 460 0.130417839017764 721 2775 A potential DNA crosslinker. SGTC_1244 0416-0015 52.5 µM 1.12284410421928 0.113492767744876 no 461 0.130751855135066 670 96201 SGTC_2861 9024595 19.48 µM 1.1222401651202 0.113617844694794 no 462 0.130880169651823 569 16482810 SGTC_1113 artemisinin 1.17947 µM 1.11982533958587 0.114118941685432 no 463 0.131394099428162 733 2240 An anti-malaria and mitochondrial poison. SGTC_2742 clothiapine 36.27 µM 1.11478717430605 0.11516946775062 no 464 0.132470816945956 635 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_171 k064-0041 9.68 µM 1.11240532268207 0.115668502649775 no 465 0.132981958557783 577 53325 SGTC_1812 st052057 4.327 µM 1.11037280378124 0.116095559931095 no 466 0.133419206244353 716 3645418 SGTC_2667 digitoxin 100 µM 1.10579484536632 0.117061541523478 no 467 0.134407663303664 615 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_749 1000-0129 128 µM 1.10422063088552 0.11739502413276 no 468 0.134748721157915 750 708470 SGTC_653 0203-0016 55.2 µM 1.10290904280887 0.117673385112862 no 469 0.135033333417732 706 295302 SGTC_2068 5226020 147 µM 1.10256091463245 0.117747347448696 no 470 0.135108945794696 733 1810509 SGTC_1520 flindersine 88 µM 1.10028760634961 0.118231137067229 no 471 0.135603415187902 728 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_564 3555-0129 330 µM 1.09812837112247 0.118691950363313 no 472 0.136074219145977 623 563260 SGTC_984 1492-0255 2.91 µM 1.09769737518243 0.118784083098726 no 473 0.136168328156811 677 1585198 SGTC_1900 st060200 72.8 µM 1.09673549258851 0.118989884067361 no 474 0.136378518165043 712 688945 SGTC_1633 st005664 67.9 µM 1.09391400814096 0.11959501084878 no 475 0.136996347216817 719 2063822 SGTC_2204 7233102 200 µM 1.09256340344395 0.119885443428597 no 476 0.137292769106509 644 2172480 SGTC_118 0083-0097 135.343 µM 1.09081487870325 0.120262182375857 no 477 0.13767717407677 926 5207356 SGTC_540 1187-0821 17.3 µM 1.08867316274794 0.120724774210696 no 478 0.138149020294343 685 847520 SGTC_1687 st020778 55.3625 µM 1.08849810349612 0.120762640771028 no 479 0.138187636677678 843 4259299 SGTC_709 3807-1509 243 µM 1.08833628455427 0.120797650793161 no 480 0.138223338921544 720 1886677 YPL242C IQG1 SGTC_2612 dictamnine 15.46 µM 1.08797788818776 0.120875216371912 no 481 0.138302434588063 676 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_783 0848-0141 92.7 µM 1.08518306155346 0.121481286451968 no 482 0.138920292378234 671 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2489 cantharidin 73.42 µM 1.0851282136203 0.121493201794937 no 483 0.138932436492044 714 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3356 9151811 4.48 µM 1.08370294215797 0.121803120484654 no 484 0.139248265351649 707 1859254 YPR165W RHO1 SGTC_486 niguldipine 82 µM 1.07706421926738 0.12325399754607 no 485 0.140725788359583 668 1236 A calcium channel blocker. SGTC_661 1304-0007 33.6 µM 1.07552255034402 0.123592651226759 no 486 0.14107042084255 716 3117130 SGTC_1801 st050089 28.441 µM 1.07529662177985 0.123642334952849 no 487 0.141120974102844 827 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1383 3049-0032 20.7 µM 1.07480204385695 0.123751145906461 no 488 0.141231682606313 720 712864 SGTC_451 chloral hydrate 100 µM 1.07378307146183 0.12397553898922 no 489 0.14145995946081 788 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1561 5-methoxyflavone 52.9 µM 1.07223318997578 0.124317391923415 no 490 0.141807653190101 683 94525 SGTC_3142 9086498 49.47 µM 1.07127941069482 0.124528091690179 no 491 0.142021907349656 688 25236367 SGTC_82 0054-0107 293.755 µM 1.07122656596814 0.124539772935212 no 492 0.142033784636558 730 3104697 SGTC_3271 9137798 49.47 µM 1.07048134520434 0.124704584407598 no 493 0.142201350732292 653 6498326 SGTC_2575 plumbagin 510 nM 1.07034406545578 0.124734961529839 no 494 0.142232233260419 709 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3062 9077494 49.47 µM 1.06873683999898 0.125090991449272 no 495 0.142594133193217 711 16459633 SGTC_2212 7123476 200 µM 1.06561730061898 0.125784050862386 no 496 0.14329833763108 647 1085715 SGTC_1897 st060201 15 µM 1.06051073676084 0.126924334290261 no 497 0.14445615400805 695 611878 SGTC_1451 4152-0210 104 µM 1.05873878991434 0.127321682214032 no 498 0.144859378435027 762 659563 SGTC_2706 st078239 82.5 µM 1.05751755142926 0.127596040425512 no 499 0.145137724349249 750 15434492 SGTC_892 0929-0076 29 µM 1.05311255263347 0.12858906244402 no 500 0.146144705217912 771 5751038 SGTC_755 1995-0008 37.3 µM 1.05203298402476 0.128833246455734 no 501 0.146392208429903 774 689533 SGTC_3165 9101544 49.47 µM 1.0503566701703 0.129213043428147 no 502 0.146777079626623 757 5002184 SGTC_1864 st057645 30.4 µM 1.04779834409971 0.129794169901837 no 503 0.147365762798946 737 688666 SGTC_817 1391-0715 46 µM 1.04194688596144 0.131130130867415 no 504 0.148718152384991 723 1353946 SGTC_1892 st058411 7.36 µM 1.04111339163324 0.131321198133482 no 505 0.148911462526819 816 3934738 SGTC_617 3770-0098 35 µM 1.03495678888243 0.132738470049905 no 506 0.150344545843845 723 5962639 SGTC_2759 disulfiram 3.38 µM 1.03456674853935 0.132828612226497 no 507 0.150435644739861 710 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1569 carminic acid 40.6 µM 1.03431491183537 0.132886836567092 no 508 0.150494483947471 786 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2398 5228213 48.84 µM 1.03356825175454 0.133059566749962 no 509 0.150669023941397 856 80771 YMR134W ERG29 SGTC_1340 1486-1359 257 µM 1.03202796874462 0.13341637942878 no 510 0.151029507719116 762 4309068 SGTC_2881 9058953 51.95 µM 1.03200903844279 0.133420768798753 no 511 0.151033941684395 814 17122249 SGTC_3001 9076041 71.4286 µM 1.02682828716831 0.134625764788102 no 512 0.152250663518911 747 16004211 SGTC_3195 9113082 49.47 µM 1.02666151707278 0.13466467770358 no 513 0.152289938005438 755 17018038 SGTC_485 niflumic acid 177 µM 1.02266063111925 0.135600529529707 no 514 0.153234165800791 743 4488 A COX2 inhibitor. SGTC_3132 9126706 49.47 µM 1.0208261105874 0.136031130794065 no 515 0.153668415690362 748 850858 SGTC_77 0828-0286 12.516 µM 1.0200613784936 0.13621090592754 no 516 0.153849676026345 767 745345 SGTC_1115 galangin 695.678 nM 1.01748863428812 0.136816906294281 no 517 0.154460518197144 838 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1502 4534-4282 27.7 µM 1.015922888529 0.137186612670049 no 518 0.154833054198269 746 3278949 SGTC_133 0724-0033 378.92 µM 1.01556313486234 0.137271654598629 no 519 0.154918733739531 757 280309 SGTC_3343 9148379 18.9835 µM 1.01503880327772 0.137395665458834 no 520 0.155043665505688 801 1955036 SGTC_1966 st070145 16.1 µM 1.01409373118551 0.137619379768767 no 521 0.15526901450876 757 3748532 SGTC_2030 5175110 200 µM 1.01135369695413 0.138269396317257 no 522 0.155923587110872 781 2831986 SGTC_860 0443-0016 25.1 µM 1.01128555639481 0.138285587886002 no 523 0.155939888501092 813 5337942 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.01050044256041 0.13847223998201 no 524 0.156127793753346 778 616764 SGTC_1446 4239-0190 62 µM 1.01041549468092 0.138492445685051 no 525 0.156148133698609 828 1340085 SGTC_2313 7726885 200 µM 1.00912083010452 0.138800643263224 no 526 0.15645834464041 753 726423 SGTC_1162 k048-0130 20.1 µM 1.00849507262664 0.138949773440443 no 527 0.156608426009291 788 6797406 SGTC_412 gemfibrozil 100 µM 1.00798878673487 0.139070511024988 no 528 0.156729922707334 743 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2195 6536160 144.242 µM 1.00607592411074 0.139527329428278 no 529 0.15718952454374 716 3834386 SGTC_419 nsc-638432 893 µM 1.00574612386335 0.139606193378265 no 530 0.157268854842473 789 368090 SGTC_2895 9054447 58.44 µM 1.00529095956962 0.139715084959901 no 531 0.15737838349007 769 2697450 SGTC_1023 4482-3888 16 µM 1.0048418585309 0.139822582576345 no 532 0.157486502235361 795 3303168 SGTC_3175 9106517 49.47 µM 1.00434660481749 0.139941192546887 no 533 0.157605788580616 776 41468073 SGTC_868 0527-0199 213 µM 1.00275524615233 0.140322775112995 no 534 0.157989483468611 808 2849450 SGTC_2463 5473429 200 µM 1.00206339582103 0.140488890019626 no 535 0.158156487656865 771 5399405 SGTC_462 ag-879 158 µM 0.999270106481613 0.141160922663913 no 536 0.158831931249209 836 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2396 5342950 42.78 µM 0.999181955898106 0.141182166079353 no 537 0.158853277618411 805 1886677 SGTC_1194 1488-0194 225 µM 0.995864904081192 0.141983118210131 no 538 0.159657894811905 826 1391452 SGTC_861 0443-0273 110 µM 0.995373858770082 0.14210194938903 no 539 0.159777233897184 816 6149169 SGTC_2061 5245884 80.95 µM 0.993588412147177 0.142534588212067 no 540 0.160211643977183 811 573863 SGTC_2235 salicylic acid 500 µM 0.991848415118143 0.142957070202607 no 541 0.160635738018135 815 338 A COX inhibitor and kinase inhibitor. SGTC_1803 st050068 52.4 µM 0.991717268277618 0.142988947721922 no 542 0.160667732469077 948 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1122 capsaicin 818.572 nM 0.991203970538894 0.143113759846346 no 543 0.160792996085859 828 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2186 6124449 200 µM 0.989912949152263 0.143428006472295 no 544 0.161108334814773 814 3834182 YLR033W RSC58 SGTC_1429 4049-0205 9.46 µM 0.989313464595673 0.143574084866112 no 545 0.161254899157351 855 22774478 SGTC_937 3122-0005 46.7 µM 0.986961047378205 0.144148276124762 no 546 0.161830867399887 857 759535 SGTC_1863 st057641 20.1 µM 0.986848462647529 0.144175795209542 no 547 0.161858466331678 867 3921635 SGTC_2100 5377183 190 µM 0.985952931744466 0.144394815957248 no 548 0.162078105274324 882 2844202 SGTC_1883 5-benzylidenerhodanine 20 µM 0.985944456780563 0.144396889756791 no 549 0.162080184780494 863 1273210 SGTC_224 benfluorex 43.875 µM 0.98500563139019 0.144626741929999 no 550 0.162310652416236 774 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1775 st081588 35.1725 µM 0.982736475328658 0.145183315646731 no 551 0.162868576887688 848 1426443 YGL099W LSG1 SGTC_2252 omeprazole 400 µM 0.982457379641428 0.145251871043754 no 552 0.162937285035614 741 4594 A proton pump inhibitor. SGTC_466 geldanamycin 89.2 µM 0.982181078320719 0.14531976150084 no 553 0.163005323822964 716 5288382 HSP90 inhibitor. SGTC_2934 9036370 36.88 µM 0.981595234163411 0.145463780851296 no 554 0.163149648159171 843 6462800 SGTC_1694 st024011 44.9 µM 0.980188353499541 0.145810029355921 no 555 0.16349657618691 866 2787533 SGTC_538 2922-0838 53.3 µM 0.978174590938537 0.146306601234121 no 556 0.163993990573311 907 777039 SGTC_286 k060-0067 22.9 µM 0.976535813218664 0.146711543074828 no 557 0.164399504742906 810 5985051 SGTC_3015 9080845 49.47 µM 0.972895071821923 0.147613858891827 no 558 0.165302727277805 885 5296973 SGTC_2152 5568786 200 µM 0.972404909400393 0.147735623313168 no 559 0.165424575266414 824 5399883 SGTC_1088 bifonazole 369 nM 0.970869712098138 0.148117426754214 no 560 0.165806581190634 813 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1156 4092-0367 4.88 µM 0.968045052350561 0.148821643110021 no 561 0.166510935022385 842 1357585 SGTC_1882 5615643 20 µM 0.967531707964941 0.148949864953501 no 562 0.166639149084666 795 2253075 SGTC_1426 4048-4480 71.7 µM 0.967467859122736 0.148965818112993 no 563 0.166655100570816 849 14224343 SGTC_1325 1431-0015 227 µM 0.965841895676917 0.149372463171794 no 564 0.167061650375561 788 1103340 SGTC_1409 3909-8004 61.9 µM 0.963492201934614 0.149961417507976 no 565 0.167650287831562 859 2119279 SGTC_348 k064-0012 10.7 µM 0.958214061067095 0.151290030537528 no 566 0.168977414140733 796 5066323 SGTC_1848 st056003 16.4 µM 0.957706592472747 0.151418181775265 no 567 0.16910536577024 903 146492 SGTC_1086 cerivastatin 2.18 µM 0.957619152597331 0.15144027028852 no 568 0.169127418883815 828 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3297 9117502 71.43 µM 0.956384296776879 0.151752440606725 no 569 0.169439057678747 867 7453720 SGTC_600 1495-0418 41.6 µM 0.953729454978766 0.152425028949514 no 570 0.17011030319655 823 5377768 SGTC_2918 7977171 22.06 µM 0.95128756156669 0.153045412230942 no 571 0.170729209702316 848 2236483 SGTC_1157 4092-0394 27.6 µM 0.951205669284966 0.153066246611283 no 572 0.170749990536974 917 3659885 SGTC_1473 k844-0725 134 µM 0.950187118571774 0.153325535251179 no 573 0.17100859136606 936 54682906 SGTC_1512 0259-0544 12.2 µM 0.947413287950941 0.154033133433941 no 574 0.171714111325029 892 18476 SGTC_1358 1509-0022 2.48 µM 0.94723379916312 0.154078994941906 no 575 0.171759828006894 882 3258434 SGTC_2274 7947094 46.08 µM 0.944769302245999 0.154709616535296 no 576 0.172388333613411 926 2971028 SGTC_1645 Cervolide 78 µM 0.94447455771209 0.154785150514823 no 577 0.172463598609362 818 23173 A fragrance. SGTC_1291 0993-0025 5.79 µM 0.943415742248532 0.15505669335876 no 578 0.172734147091466 889 4353356 SGTC_992 3909-8734 162 µM 0.943403059788578 0.155059947796071 no 579 0.172737389351898 842 4288319 SGTC_1906 st060206 94.7 µM 0.943354299767731 0.155072460491468 no 580 0.172749855172311 922 5133468 SGTC_2967 9089538 49.85 µM 0.943306456830299 0.155084738494816 no 581 0.172762087091651 874 728216 SGTC_1171 0368-0077 21.4 µM 0.943175208375872 0.155118424274154 no 582 0.172795645986759 817 3239779 SGTC_1516 st013856 110 µM 0.941261087656893 0.155610244875942 no 583 0.173285539267035 819 5281404 A mutagen and neurotoxin. SGTC_893 0958-0369 48.9 µM 0.937154673922296 0.156668827129241 no 584 0.174339500574474 890 6819948 SGTC_446 go6976 132 µM 0.936479660640829 0.156843289709058 no 585 0.174513139956058 837 3501 A protein kinase C inhibitor. SGTC_2572 astragaloside iv 100 µM 0.935928307174911 0.156985886237365 no 586 0.174655050745657 854 45006101 An anti-inflammatory agent. SGTC_450 aminopyrene 156 nM 0.935510072517115 0.15709411111778 no 587 0.174762747443399 866 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1025 k007-0731 70 µM 0.934716396569876 0.157299622295111 no 588 0.174967237291933 854 6256118 SGTC_1917 st066507 28.5 µM 0.927958986937057 0.15905651360861 no 589 0.176714422241769 880 3156428 SGTC_932 2857-0803 154 µM 0.927841927169565 0.159087061389136 no 590 0.17674478590106 929 674898 SGTC_2491 paeonol 100 µM 0.927476645982571 0.159182409450115 no 591 0.176839555912325 858 11092 Increases levels of cortical cytochrome oxidase. SGTC_935 2996-0153 430 µM 0.925795619385344 0.159621684291743 no 592 0.177276102083033 885 23738523 SGTC_1620 st003704 16.5 µM 0.925753399676758 0.15963272707172 no 593 0.177287074881962 892 2834414 SGTC_362 0310-0100 9.03 µM 0.924429204271939 0.159979330866746 no 594 0.177631447688364 855 790235 SGTC_916 4466-0038 42 nM 0.922304974956637 0.160536368134595 no 595 0.178184759882407 978 5722064 YGL116W CDC20 SGTC_1822 st052468 42 µM 0.921044912175847 0.160867392752589 no 596 0.178513489614699 882 2873678 SGTC_2768 sulfasalazine 50.2 µM 0.920850550239929 0.160918492217469 no 597 0.178564229443225 905 5384001 An antioxidant and salicylic acid derivative. SGTC_1404 3909-7820 48.3 µM 0.920329784982009 0.161055458211632 no 598 0.17870022438828 892 23741373 SGTC_206 4546-0025 72.014 µM 0.91947025778055 0.1612816880335 no 599 0.178924827727526 929 6620745 YIL048W NEO1 SGTC_2977 9011197 71.43 µM 0.918046134571343 0.161656977029689 no 600 0.179297356677798 815 2704722 SGTC_353 1988-1175 58.3 µM 0.91660554879811 0.162037182931811 no 601 0.179674687833888 844 2788357 SGTC_1573 oleylamine 1.06 µM 0.915672703325864 0.162283694150494 no 602 0.179919293056421 871 5356789 An amine of the fatty acid oleic acid. SGTC_1217 1183-1422 255 µM 0.911906368444868 0.163281456961916 no 603 0.180909004410215 952 2849664 SGTC_2378 9074213 121.43 µM 0.905513992191656 0.164984003453531 no 604 0.182596575287254 908 657714 SGTC_1370 2001-0092 44.6 µM 0.905149056425939 0.165081546125512 no 605 0.182693213112967 1000 790957 SGTC_342 k048-0088 23.3 µM 0.904777587068924 0.1651808734782 no 606 0.182791613873711 884 6820570 SGTC_2583 asiatic acid 100 µM 0.904234681861422 0.165326110703044 no 607 0.182935486810091 885 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1323 1348-1351 11.2 µM 0.903655596211697 0.165481117915151 no 608 0.183089025632638 872 6989654 SGTC_2243 6634756 200 µM 0.900394828053824 0.166355701029866 no 609 0.183955086091825 875 885676 SGTC_18 0111-0177 500 nM 0.899498406620899 0.16659665576571 no 610 0.184193622071004 1008 721752 SGTC_1590 st077108 57.8 µM 0.898575753080757 0.166844896713998 no 611 0.184439339306539 905 5489485 SGTC_140 0062-0056 502.533 µM 0.897855906407273 0.167038737874544 no 612 0.184631187396368 990 3758964 SGTC_1428 4049-0204 61.7 µM 0.896484856291658 0.167408337404126 no 613 0.18499693238489 954 X1428 SGTC_2986 9022445 71.43 µM 0.893239758941096 0.168285229352277 no 614 0.185864395275444 928 6459286 SGTC_317 4495-0002 170 µM 0.88985824159927 0.169202122318654 no 615 0.186771004365109 879 15991618 SGTC_1642 st009582 77.7 µM 0.886408848185609 0.170140717959735 no 616 0.187698626472267 905 6739311 SGTC_781 4335-2806 94.4 µM 0.886165142050115 0.170207157462235 no 617 0.187764272184372 1020 845254 SGTC_512 prima-1 270 µM 0.882064855908045 0.171327475088549 no 618 0.188870867933571 967 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1782 st039423 80.636 µM 0.880921906218361 0.171640600502557 no 619 0.189180044897273 863 2068169 SGTC_39 0986-0283 58.349 µM 0.880788580048295 0.171677150677585 no 620 0.189216130970923 993 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_872 0588-0139 234 µM 0.880218590976606 0.17183346413476 no 621 0.189370452051363 976 2047100 SGTC_2436 5633522 8.09 µM 0.877899343339081 0.172470430143745 no 622 0.189999172801634 974 5724242 SGTC_2441 5730946 39.09 µM 0.877765936687472 0.172507115142502 no 623 0.190035376757433 946 1774275 SGTC_2659 sanguinarine 24.21 µM 0.877327454800173 0.172627726699645 no 624 0.190154402032759 894 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1842 st055362 61.2 µM 0.876847159100608 0.172759901509306 no 625 0.190284830162821 986 676032 SGTC_1648 st011736 69.8 µM 0.876302747022219 0.172909798779972 no 626 0.190432736038589 917 2855514 SGTC_1796 st049173 110.4 µM 0.876284914401772 0.172914710177364 no 627 0.190437581998828 897 94134 SGTC_759 3486-0358 89.3 µM 0.875856581645158 0.17303270678362 no 628 0.19055400287287 1007 875103 SGTC_1754 st042065 16.137 µM 0.875149192839246 0.173227689704459 no 629 0.190746366844204 991 1126236 YIL048W NEO1 SGTC_2330 7979373 200 µM 0.874693058865485 0.173353491525143 no 630 0.190870468935653 906 1863007 SGTC_3027 9089541 49.47 µM 0.873178462133686 0.173771634618731 no 631 0.191282906191165 926 9943819 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.870321492914845 0.174562118699347 no 632 0.19206236824075 892 77254 SGTC_742 0kpi-0133 140 µM 0.868267577636149 0.175131817489217 no 633 0.19262393354576 971 2728852 SGTC_3312 9133330 71.43 µM 0.867655158877759 0.175301913357793 no 634 0.19279157027107 1006 17617324 SGTC_86 0417-1630 471.922 µM 0.86723135594099 0.175419683548712 no 635 0.192907629556048 1051 3634867 SGTC_480 am 92016 50 µM 0.866782117237472 0.175544576808943 no 636 0.19303070105813 909 2129 K+ channel blocker. SGTC_1292 0kpi-0043 232 µM 0.865939154639059 0.175779081648262 no 637 0.193261764814358 913 3333905 SGTC_3183 9108214 49.47 µM 0.863365017626106 0.176496411618212 no 638 0.193968403440636 881 4974831 SGTC_3019 9081971 49.47 µM 0.86006558303325 0.177418562412176 no 639 0.194876445880897 1017 16451803 SGTC_739 1486-1183 203 µM 0.860058353699277 0.177420586254568 no 640 0.194878438311066 995 4346692 SGTC_3128 9127691 49.47 µM 0.858888772460415 0.177748200860968 no 641 0.195200942168534 854 41316314 SGTC_1734 st037168 69.4 µM 0.858000207564983 0.177997354158324 no 642 0.195446174406388 923 708907 SGTC_2961 9083290 32.55 µM 0.857163503375927 0.178232166939036 no 643 0.195677264749455 917 17741490 SGTC_557 1315-0110 16.2 µM 0.855401930808077 0.178727172754817 no 644 0.196164337540443 1020 6833801 SGTC_1613 st002381 52.1 µM 0.855104996684795 0.178810697071031 no 645 0.196246511834538 1018 551167 SGTC_81 0411-0046 9.971 µM 0.850976933818139 0.179974420137207 no 646 0.197391083054659 894 12925265 SGTC_2060 5238662 140 µM 0.850958947915796 0.179979500842965 no 647 0.197396078749434 909 790130 SGTC_2253 7938677 135.83 µM 0.849941953328405 0.180266930707056 no 648 0.197678679618158 983 2301972 SGTC_2105 5350118 200 µM 0.849861542189883 0.18028966932738 no 649 0.197701034566117 982 2133313 SGTC_3016 9080866 49.47 µM 0.847476964605106 0.180964796904245 no 650 0.19836466068971 1016 17066299 SGTC_1804 st050076 49.1 µM 0.847170422788518 0.181051700565971 no 651 0.198450068446312 963 3895976 SGTC_302 1094-0063 18.9 µM 0.846459230058013 0.181253422197886 no 652 0.19864830424972 910 5440289 SGTC_987 1497-1013 404 µM 0.845643405972633 0.181484994575418 no 653 0.198875851700759 1001 1676435 SGTC_3154 9100113 49.47 µM 0.845630775159929 0.18148858129783 no 654 0.198879375887521 965 25237525 SGTC_3325 9138760 55.175 µM 0.842885518319082 0.182269193774548 no 655 0.199646236752861 959 43844959 SGTC_1410 3909-8106 77.9 µM 0.842882765252697 0.182269977659322 no 656 0.199647006687208 983 1039210 SGTC_1833 st055984 71 µM 0.841460405962053 0.18267524987016 no 657 0.200045028653976 947 676288 SGTC_2370 9071495 200 µM 0.840166213240831 0.183044492114349 no 658 0.200407599660072 918 21791103 SGTC_1824 st053723 68.6 µM 0.838394420901433 0.183550751392128 no 659 0.200904610897897 1018 675225 SGTC_316 k060-0003 58.6 µM 0.838005717682418 0.183661933284854 no 660 0.201013746144342 969 6152314 SGTC_1594 piperine 70.1 µM 0.837967473425433 0.183672874665968 no 661 0.201024485811573 977 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2795 7780010 54.55 µM 0.835762103579717 0.184304500464397 no 662 0.201644374900525 930 953673 SGTC_657 3534-0529 86.7 µM 0.834921637318744 0.184545568262526 no 663 0.201880915591517 1013 1049549 SGTC_791 1348-1292 225 µM 0.834719280714246 0.184603638729381 no 664 0.201937891605768 1050 5437054 SGTC_2025 5147754 141 µM 0.833394061961513 0.184984218828905 no 665 0.202311261275386 995 315777 YLR208W SEC13 SGTC_123 0083-0120 66.675 µM 0.832947770721422 0.185112495674245 no 666 0.20243709310375 978 16001701 SGTC_1190 1486-1332 13 µM 0.83218063632799 0.185333121084101 no 667 0.202653495990853 991 4150046 SGTC_565 1418-0001 44.5 µM 0.830447288511602 0.185832227276831 no 668 0.203142969306767 1042 2862145 SGTC_2842 9000675 19.48 µM 0.830063420021915 0.185942872351574 no 669 0.20325146380969 958 2989072 SGTC_192 3455-0609 60.9 µM 0.829709313873373 0.18604497503346 no 670 0.203351577104919 994 3769639 SGTC_1074 carmofur 3.8 µM 0.827763790909078 0.186606565411011 no 671 0.203902142299408 1076 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3272 9137413 49.47 µM 0.825710796612239 0.187200315130345 no 672 0.204484083128196 1023 17614870 SGTC_3242 9133940 49.47 µM 0.824795712637821 0.187465344015218 no 673 0.204743790583316 1050 17248444 SGTC_3176 9106582 49.47 µM 0.824428746628477 0.187571690731369 no 674 0.204847993281842 906 17018027 SGTC_1954 st077032 68.9 µM 0.824175544057918 0.187645090543031 no 675 0.204919910398258 945 698907 SGTC_2275 7947463 200 µM 0.824091411671529 0.187669483248286 no 676 0.204943809838998 993 1225414 SGTC_2045 5106652 78.05 µM 0.822798282293299 0.188044649764458 no 677 0.205311356827601 1028 673349 SGTC_1118 chelidonine 707.474 nM 0.821898490649746 0.188305972914694 no 678 0.20556733604288 1072 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2190 6049624 200 µM 0.821174109811583 0.188516514855977 no 679 0.20577355072803 977 2265554 SGTC_1889 st059080 5.18 µM 0.819386020801039 0.189036845614285 no 680 0.206283104031885 1041 176925 Isolated from Daphnopsis sellowiana. SGTC_1391 3442-0225 151 µM 0.815864309161017 0.190064241274261 no 681 0.207288873585094 974 5227075 SGTC_97 0535-0701 19.132 µM 0.814528687243853 0.190454780657589 no 682 0.207671072462432 968 2832013 YGL099W LSG1 SGTC_708 3448-5400 146 µM 0.814473809698108 0.190470837529423 no 683 0.207686785009773 1037 3462195 SGTC_1179 1021-1431 9.29 µM 0.814012449131747 0.190605861993063 no 684 0.207818909608063 1040 2840958 SGTC_21 0849-0113 22.993 µM 0.813373025991767 0.190793096406634 no 685 0.208002109882741 1025 1560156 SGTC_2506 ethyl hematommate 54.16 µM 0.812513998314589 0.191044812497565 no 686 0.208248378780946 945 3940691 An allergen. SGTC_2027 5150920 200 µM 0.810857645074942 0.191530739062254 no 687 0.20872371296992 1031 786715 SGTC_3235 9132602 49.47 µM 0.808479657104038 0.192229695056034 no 688 0.209407256090522 1067 4912240 SGTC_1636 st007707 68.9 µM 0.808386381177724 0.192257143176102 no 689 0.209434094701089 1050 403051 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.801283024923406 0.194354470808468 no 690 0.211483907888395 966 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2878 9043973 25.97 µM 0.801212601131368 0.194375333538788 no 691 0.21150428869487 1026 6465167 SGTC_418 lividomycin a 100 µM 0.800546596425595 0.19457270183548 no 692 0.211697088839155 1083 72394 An antibiotic. SGTC_2358 9037157 4 µM 0.798456276539305 0.195192952881981 no 693 0.212302878309191 1024 2388925 SGTC_2187 6125751 200 µM 0.798027912852434 0.195320207468761 no 694 0.212427146096679 1019 874498 SGTC_150 3970-0969 77.2 µM 0.797606465327694 0.195445456639039 no 695 0.212549448978228 1039 6615640 SGTC_111 0083-0039 52.457 µM 0.796121347005265 0.195887204751401 no 696 0.212980753814676 975 759313 SGTC_1226 3909-7979 35.4 µM 0.795976604927974 0.195930290626579 no 697 0.213022816788059 1063 6615510 SGTC_1611 st001856 99.4 µM 0.794141858892501 0.19647694408083 no 698 0.213556425688632 1022 647478 SGTC_1939 st074455 53.6 µM 0.793077018910748 0.196794631294734 no 699 0.213866475601425 1040 1644229 SGTC_432 NS 1619 61.3 µM 0.792887630779926 0.196851166421916 no 700 0.213921647265748 972 4552 A K+/calcium channel activator. SGTC_1752 st044819 83.042 µM 0.79262031122652 0.196930981953052 no 701 0.213999535648262 1032 441209 YML126C ERG13 SGTC_3241 9133421 49.47 µM 0.791762273476759 0.197187304820046 no 702 0.214249651953202 1081 17018221 SGTC_1389 3405-0187 19 µM 0.791344109307783 0.197312296736312 no 703 0.214371607589395 1001 799890 SGTC_2602 kawain 100 µM 0.788728425567682 0.19809522803794 no 704 0.215135375161991 1087 5369129 SGTC_3215 9129942 49.47 µM 0.787597943002478 0.198434185923319 no 705 0.215465959137572 1006 17682944 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.787568129069231 0.198443129908161 no 706 0.215474681531997 1103 165521 SGTC_134 0269-0018 6.916 µM 0.786847422966753 0.198659411019668 no 707 0.21568559434648 971 4378915 SGTC_3009 9080819 71.4286 µM 0.786808444686898 0.198671112301108 no 708 0.215697004651911 1072 17027216 SGTC_2118 5526350 200 µM 0.786359471693707 0.198805923978083 no 709 0.215828459974155 1059 743594 SGTC_3032 9089427 49.47 µM 0.785099743384535 0.199184472884114 no 710 0.216197545089549 1046 17173707 SGTC_2862 9027634 71.43 µM 0.784834693857141 0.199264175632598 no 711 0.216275247898105 1022 5012562 SGTC_1787 fluconazole 80 µM 0.784322472005231 0.19941825971113 no 712 0.216425458379812 1017 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2350 9023895 38.85 µM 0.783895479428503 0.199546760338841 no 713 0.216550721269874 1038 2997209 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.782129991104254 0.200078601310843 no 714 0.217069091411816 1022 17037758 SGTC_1769 st044406 64.4 µM 0.782016199147683 0.200112909544734 no 715 0.217102526775819 1054 670903 SGTC_340 k038-0059 454 µM 0.781306326122762 0.200327015832835 no 716 0.217311175148927 1068 23733424 SGTC_2426 5582046 32.21 µM 0.779690492999073 0.200814883546396 no 717 0.217786538047494 1058 2251934 SGTC_2731 amoxapine 43.43 µM 0.779678879020833 0.200818392728194 no 718 0.217789956940292 1077 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.778782949957494 0.201089210011423 no 719 0.218053791511908 1116 1377 SGTC_2083 5306046 65.942 µM 0.778338985465092 0.20122349066615 no 720 0.218184599101338 1083 539837 SGTC_2276 7947513 42.08 µM 0.776528471298276 0.20177165177018 no 721 0.21871850839674 1023 2105100 SGTC_2851 9015922 71.43 µM 0.776014582005529 0.201927402461483 no 722 0.218870188023739 1055 2996893 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.775398888906653 0.20211410281233 no 723 0.219051995738098 1073 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1367 1812-0510 76.9 µM 0.775143297228723 0.202191637756529 no 724 0.219127494782168 1061 1142582 YDR527W RBA50 SGTC_2008 4012253 172 µM 0.77380912386893 0.202596654348847 no 725 0.219521838105807 1068 603940 SGTC_1108 betulinic acid 729.144 nM 0.773610917432888 0.202656865457391 no 726 0.2195804569936 1102 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_770 0389-1121 67.2 µM 0.773147505052391 0.202797682496277 no 727 0.219717544724074 1121 6753108 SGTC_2919 7978188 46.38 µM 0.771017367689613 0.203445718529335 no 728 0.220348318632998 1090 2980291 SGTC_2866 9034245 58.44 µM 0.770937980119497 0.203469893880254 no 729 0.220371846839739 1088 6462273 SGTC_3334 9142812 21.919 µM 0.77086868773072 0.203490996415605 no 730 0.220392384300272 1040 45283678 SGTC_8 0354-0001 70 µM 0.770323207226591 0.203657164454714 no 731 0.220554096703659 1143 4993152 SGTC_1337 1486-1011 40.3 µM 0.767590994957748 0.204490686631635 no 732 0.221365106994343 1124 X1337 SGTC_761 k216-0224 480 µM 0.766534022340442 0.204813683520945 no 733 0.221679308048552 1129 1340404 SGTC_1424 4048-1941 275 µM 0.766324774262042 0.20487766293272 no 734 0.221741540399784 1148 X1424 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.765578612510129 0.205105905074434 no 735 0.221963537176225 1169 65057 A dermal irritant. YDR527W RBA50 SGTC_804 1595-0054 20.9 µM 0.765443519273528 0.205147244663969 no 736 0.222003743450182 1043 761523 Stimulates phospholipase C. SGTC_802 4112-3352 742 µM 0.765092797343975 0.205254591434629 no 737 0.222108144264312 1116 704594 SGTC_886 0866-0150 153 µM 0.76434426714486 0.205483808453283 no 738 0.222331055977827 1135 271463 SGTC_666 0272-0154 136 µM 0.762027493983349 0.206194219838188 no 739 0.223021797470116 1097 6870312 SGTC_1114 scopoletin 1.73284 µM 0.760121221859158 0.206779846300982 no 740 0.223591064237862 1099 5280460 A coumarin with genotoxic properties. SGTC_2401 5128683 200 µM 0.759427434358227 0.206993229144357 no 741 0.223798453736779 1071 708373 SGTC_1650 st011916 45.8 µM 0.75778420915265 0.207499142656905 no 742 0.224290088554757 1100 242528 SGTC_3220 9131269 49.47 µM 0.757149265959374 0.207694823523673 no 743 0.224480220649458 1125 17722206 SGTC_1227 3909-8010 46.6 µM 0.753751561407409 0.208743800995297 no 744 0.225499207315047 1063 15982272 SGTC_760 0568-0725 82.9 µM 0.753631820370119 0.208780825657549 no 745 0.225535165878933 1131 3916171 SGTC_2424 5537928 59.2 µM 0.750782385695034 0.209663029498301 no 746 0.226391815893643 1174 5382802 SGTC_1970 st070122 35.8 µM 0.750214798276384 0.209839019781494 no 747 0.226562673785942 1132 102928 SGTC_370 0180-0345 38.7 µM 0.748187978323054 0.210468178611304 no 748 0.227173390586323 1038 3989527 SGTC_93 0109-0045 59.227 µM 0.747003112183785 0.210836493166452 no 749 0.227530841116666 1226 88733 SGTC_1369 1866-0067 208 µM 0.74601337047813 0.211144443016996 no 750 0.227829669122706 1150 3531355 SGTC_518 1021-0119 62.6 µM 0.745872658486584 0.211188245767307 no 751 0.227872171549029 1031 1097762 SGTC_228 caffeine 993.056 µM 0.743804934598168 0.211832528876264 no 752 0.228497247198484 1082 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1843 st055809 45.5 µM 0.743358967755171 0.211971638519202 no 753 0.228632189732011 1079 16413835 SGTC_1865 st057639 52.2 µM 0.742764311141671 0.212157211795748 no 754 0.228812193049095 1137 688818 SGTC_1356 1502-0781 85.8 µM 0.7424629043263 0.212251307466064 no 755 0.228903459647679 1067 567702 SGTC_714 4296-0578 26.1 µM 0.741442516705183 0.212570041527826 no 756 0.229212586707672 1138 1589775 SGTC_1749 st037932 54.2 µM 0.740314223055399 0.212922806982578 no 757 0.229554676341312 1068 594497 SGTC_3313 9133968 57.047 µM 0.737553824324746 0.213787295494736 no 758 0.230392812018126 1130 1494643 SGTC_2257 7960413 200 µM 0.737292468410342 0.213869251489916 no 759 0.230472255682973 1133 2974689 YIL048W NEO1 SGTC_2270 7924575 90.91 µM 0.736220040970147 0.214205734802152 no 760 0.230798398883115 1118 1262135 SGTC_2780 5215298 71.43 µM 0.734640457804969 0.21470190308711 no 761 0.231279245754597 1154 2834131 SGTC_210 3551-0445 56.827 µM 0.732848993590083 0.21526543349871 no 762 0.231825267775045 1160 2865180 YOR207C RET1 SGTC_297 0986-0032 24 µM 0.729437950814086 0.216340795172227 no 763 0.232866905173502 1125 2847425 SGTC_3261 9137475 49.47 µM 0.728656763445734 0.216587508360336 no 764 0.233105823427451 1008 17027690 SGTC_2825 7998094 58.44 µM 0.728603932134221 0.21660419932389 no 765 0.233121986261482 1100 2987815 SGTC_3269 9137823 49.47 µM 0.728284295664655 0.216705197743639 no 766 0.233219786827905 1083 17682936 SGTC_2268 7933382 153.85 µM 0.727199228496162 0.217048259303381 no 767 0.233551959382976 1213 935025 YOR257W CDC31 SGTC_305 1682-2595 20.8 µM 0.724982528466986 0.217750079530042 no 768 0.234231374484838 1158 226033 SGTC_2738 aclarubicin 5.55 µM 0.720147874127063 0.219285292367562 no 769 0.235716976966339 1067 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1199 1638-0010 4.46 µM 0.719106589090854 0.219616757969826 no 770 0.236037623895911 1147 3111136 SGTC_1746 st038117 42 µM 0.718984925465078 0.219655505137882 no 771 0.236075103921381 1145 2898218 SGTC_1679 SEC14.276 6.7 µM 0.717286811631805 0.220196726364698 no 772 0.23659857158039 1200 1005053 YMR079W SEC14 SGTC_1125 tnp00248 1.32998 µM 0.717126975804906 0.220247708436471 no 773 0.236647876102768 1256 24207736 SGTC_1672 st016598 6.51 µM 0.716215083975546 0.220538699653815 no 774 0.236929275257895 1105 4665860 YNL267W PIK1 SGTC_3205 9113483 49.47 µM 0.71560904494131 0.220732212843067 no 775 0.237116393516184 1161 17018033 SGTC_98 0074-0023 107.663 µM 0.714896213651639 0.220959950080561 no 776 0.237336588416928 1162 3563821 SGTC_344 k064-0035 6.43 µM 0.714525820083015 0.221078337482238 no 777 0.237451047989706 1146 5088750 SGTC_900 1112-0045 141 µM 0.711220090662856 0.22213654074892 no 778 0.238473930332656 1087 56211 YIL048W NEO1 SGTC_2833 9001315 45.46 µM 0.70935222189756 0.22273574372231 no 779 0.239052964533741 1156 2989378 SGTC_2745 rifampicin 24.3 µM 0.708570271347911 0.222986862828481 no 780 0.239295595087693 1097 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1444 4112-3581 28 µM 0.7057636689689 0.223889514596273 no 781 0.24016755953692 1197 2877249 SGTC_293 4049-0273 38.5 µM 0.705580035657684 0.223948646526892 no 782 0.240224671635591 1114 1380311 SGTC_51 1013-0126 23.419 µM 0.704748369422621 0.224216563208843 no 783 0.240483422161374 1240 1627850 SGTC_2474 5321570 43.32 µM 0.703782127400284 0.224528061170034 no 784 0.240784232818488 1188 2841384 SGTC_2386 9075165 157.42 µM 0.703022831180861 0.224773015953127 no 785 0.241020760656168 1172 16452277 SGTC_2723 salbutamol 83.58 µM 0.702815457642411 0.22483994258245 no 786 0.241085381402168 1146 9884233 β2-adrenoceptor agonist SGTC_389 tpck 16.7 µM 0.702651815707258 0.224892763481861 no 787 0.241136381364943 1170 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_470 aa-861 153 µM 0.702190051778754 0.22504185113493 no 788 0.24128032440432 1176 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1124 fisetin 1.16336 µM 0.701982102463872 0.22510900908524 no 789 0.241345162505231 1150 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3287 9117173 37.0625 µM 0.700939395085379 0.22544592620275 no 790 0.241670418878067 1158 2789709 SGTC_2820 7989630 71.43 µM 0.70086615407032 0.225469602389476 no 791 0.241693274215963 1086 2984098 SGTC_710 3448-4187 58 µM 0.700561368684991 0.225568143659891 no 792 0.241788397088537 1211 3946412 SGTC_1198 1612-1005 86.7 µM 0.700157660111798 0.225698705660355 no 793 0.241914424949695 1233 6998509 SGTC_2966 9084041 48.03 µM 0.699651714202389 0.22586239223484 no 794 0.24207241908926 1128 17741380 SGTC_1698 5-fluorocytosine 1.055 µM 0.699145682631859 0.226026173651948 no 795 0.242230495930436 1208 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_757 1066-0008 322 µM 0.699065728125316 0.226052057747657 no 796 0.242255477663434 1170 6842497 SGTC_1020 4335-0961 93.3 µM 0.698757138698772 0.226151974747509 no 797 0.242351909320989 1118 669075 SGTC_1977 st070720 65.3 µM 0.698687258864088 0.226174604339276 no 798 0.242373749082494 1177 682188 SGTC_2945 9067681 61.76 µM 0.698148981352396 0.226348960747425 no 799 0.242542014361128 1258 16456930 SGTC_798 1287-0182 476 µM 0.696184392428943 0.22698596525048 no 800 0.243156680337645 1230 1649755 SGTC_201 4262-0159 12.803 µM 0.695921468248125 0.227071293250031 no 801 0.243239005955158 1154 1341029 SGTC_826 1683-5028 118 µM 0.695903253811349 0.227077205135119 no 802 0.243244709734335 1202 722377 SGTC_2882 9058044 58.44 µM 0.693539270710593 0.227845222539768 no 803 0.243985594988132 1161 18076804 SGTC_1168 k815-0004 80.5 µM 0.692541114318024 0.228169944723099 no 804 0.244298787814963 1194 642433 SGTC_1505 k297-0037 20.6 µM 0.6922136074548 0.228276546560786 no 805 0.244401597264544 1203 4089396 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.691890358126388 0.228381790038063 no 806 0.244503093065844 1169 689007 SGTC_2823 7987624 58.44 µM 0.691610421052473 0.228472953943206 no 807 0.244591007764089 1228 2239440 SGTC_3299 9121982 43.1275 µM 0.688406842740057 0.229517681201235 no 808 0.245598307976073 1228 17594604 YPL160W CDC60 SGTC_2484 5809818 12.04 µM 0.687928693714817 0.229673840877577 no 809 0.245748843105543 1209 2870548 SGTC_1765 st044815 90.4 µM 0.687092493019016 0.229947080373682 no 810 0.246012222272783 1194 645695 SGTC_1884 5633444 25 µM 0.68371653971836 0.231052065289155 no 811 0.247077088606854 1222 5724239 SGTC_956 1185-0240 191 µM 0.682856331543514 0.231334093497653 no 812 0.247348815012241 1220 1416193 SGTC_1757 st041620 31.8375 µM 0.681343084774659 0.231830692865558 no 813 0.247827213580266 1231 5289815 SGTC_2096 5468907 200 µM 0.681051307943022 0.231926512965001 no 814 0.247919512818615 1228 759785 SGTC_855 0428-0020 25 µM 0.680411639149958 0.232136658644253 no 815 0.248121926659657 1209 6812414 SGTC_2617 dihydrotanshinone i 20.83 µM 0.679241491244522 0.23252135284016 no 816 0.248492430863635 1258 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_923 1900-2434 73.3 µM 0.677405244773912 0.233125745502848 no 817 0.249074435783211 1216 5910570 SGTC_38 0929-0051 58.268 µM 0.676119806229644 0.233549360553351 no 818 0.249482291260863 1225 1379719 SGTC_1011 4112-3381 17.4 µM 0.674490759476595 0.234086824122676 no 819 0.249999679274407 1275 2877139 SGTC_3101 9120531 49.47 µM 0.672972132040586 0.234588473869299 no 820 0.250482510221844 1289 24824904 SGTC_721 1187-1332 279 µM 0.671789371795264 0.234979587781354 no 821 0.250858897901019 1178 25730 SGTC_581 0958-0271 211 µM 0.671652652734045 0.235024821115522 no 822 0.250902425059647 1244 4591145 SGTC_2046 4110841 106 µM 0.670850586867621 0.235290280491944 no 823 0.25115785874201 1246 44119630 YMR134W ERG29 SGTC_2994 9053520 71.4286 µM 0.670738779096479 0.235327298600746 no 824 0.251193477050204 1220 4647384 SGTC_1400 3771-8998 51.5 µM 0.668174181431065 0.236177285814553 no 825 0.252011207055952 1192 670767 SGTC_3248 9135562 49.47 µM 0.666953550645587 0.236582433907522 no 826 0.25240090179652 1268 17650701 SGTC_1188 1403-0014 4.57 µM 0.666014603215024 0.236894346544746 no 827 0.252700883182839 1276 9614867 SGTC_1922 5578187 25 µM 0.665919749420802 0.236925868967701 no 828 0.252731198164196 1284 1350412 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.662953027745038 0.237912951996971 no 829 0.25368031908911 1208 390807 SGTC_404 fumagillin 50 µM 0.662443030299685 0.238082864392503 no 830 0.253843667079987 1242 12015870 A methionine aminopeptidase binder. SGTC_821 1114-0266 29.2 µM 0.661111678381269 0.238526735145323 no 831 0.254270348214587 1246 3123235 SGTC_903 1134-0042 114 µM 0.660676048049926 0.238672071953597 no 832 0.254410043725634 1243 701009 SGTC_2381 9035592 200 µM 0.659995699680636 0.238899149517373 no 833 0.254628294490123 1199 4749657 SGTC_109 0132-0036 33.701 µM 0.65973339201207 0.238986730604158 no 834 0.254712467050178 1149 67274 A color developer. SGTC_669 0108-0021 26.2 µM 0.659036083810926 0.23921963799592 no 835 0.254936298840677 1359 17201 SGTC_1048 3161-0300 24.5 µM 0.657905769492 0.239597436754392 no 836 0.255299341551274 1262 2165101 SGTC_278 4092-0821 23.9 µM 0.656814081261697 0.239962634012758 no 837 0.255650234439451 1252 877900 SGTC_2057 5236571 38.335 µM 0.655708110604275 0.240332918424076 no 838 0.256005974670392 1256 54684039 YBR257W POP4 SGTC_2898 9056270 58.44 µM 0.65478072505608 0.240643651454075 no 839 0.256304471171592 1197 19154699 SGTC_456 gingerol 170 µM 0.65441038556065 0.240767799771075 no 840 0.256423722579156 1306 442793 A herb. SGTC_1203 3992-3522 103 µM 0.651164550705711 0.241857385706117 no 841 0.257470135518182 1452 5322312 SGTC_2955 9076254 12.21 µM 0.64975671824077 0.24233080790198 no 842 0.25792469030178 1198 16459619 SGTC_2618 avocadyne 43.43 µM 0.649459599407647 0.242430786376526 no 843 0.258020675908955 1229 3015189 SGTC_369 0957-0393 4.5 µM 0.649337174011368 0.242471988192762 no 844 0.258060231385996 1244 6997992 SGTC_2413 inermin 26.06 µM 0.648842451816241 0.242638523752688 no 845 0.258220107471781 1378 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3086 9117350 49.47 µM 0.648557800622394 0.242734372349435 no 846 0.258312119571532 1199 2679265 SGTC_3077 9117319 49.47 µM 0.648212396382213 0.242850705410662 no 847 0.258423792608357 1268 17154678 SGTC_3218 9131285 49.47 µM 0.647187466477869 0.243196082029385 no 848 0.258755311018522 1300 17156417 SGTC_1868 st057644 42.7 µM 0.646331353938218 0.243484774694045 no 849 0.259032393276065 1271 688665 SGTC_1480 1070-0044 41.2 µM 0.645639418224018 0.243718239937058 no 850 0.259256451500457 1285 3124987 SGTC_2440 5628896 157.78 µM 0.645108478039334 0.243897465774445 no 851 0.2594284450652 1298 5522048 SGTC_45 0kpi-0036 14.9 µM 0.645090407767025 0.243903566883555 no 852 0.259434299813431 1280 2795021 SGTC_850 0388-0143 75.9 µM 0.643077316814555 0.244583766914941 no 853 0.260086966108013 1248 67273 SGTC_3127 9126946 49.47 µM 0.640309931181504 0.245520499523938 no 854 0.260985562754121 1236 27243249 SGTC_601 0986-0029 62.9 µM 0.639297350610977 0.245863729018596 no 855 0.261314755839331 1276 24747981 SGTC_65 0798-0905 34.986 µM 0.638002190105232 0.246303118349272 no 856 0.261736127213996 1457 3602145 SGTC_2589 lobaric acid 100 µM 0.637144332481551 0.246594382194338 no 857 0.262015416961037 1267 73157 A novel microtubule depolymerizer. SGTC_535 2293-4129 48.2 µM 0.635865844632376 0.247028802528158 no 858 0.262431933159667 1299 396118 YIL048W NEO1 SGTC_2306 7482397 179.52 µM 0.635021095561281 0.247316066255587 no 859 0.262707328281523 1337 891448 SGTC_1071 trifluoperazine 6.31 µM 0.634412141241548 0.247523256792813 no 860 0.262905944044905 1333 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1839 st053978 48 µM 0.631184600506222 0.248622941429398 no 861 0.263959914883586 1335 3788398 SGTC_1350 1495-0454 146 µM 0.631166954422072 0.248628960931306 no 862 0.263965683221217 1325 1069057 SGTC_1146 3579-1023 7 µM 0.630460459456485 0.248870027043099 no 863 0.264196682494392 1370 X1146 SGTC_2777 climbazole 1.536 µM 0.630415988559973 0.248885205305442 no 864 0.264211226373916 1277 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.630175593501918 0.248967262535868 no 865 0.264289852868081 1303 551469 SGTC_296 1222-0039 74.9 µM 0.628511085986601 0.24953582567869 no 866 0.26483459332179 1256 5984176 SGTC_2912 7964298 10.93 µM 0.628290231063762 0.249611317198369 no 867 0.264906914991235 1312 2975850 SGTC_1386 3228-0095 33.8 µM 0.627300407536113 0.249949802675948 no 868 0.265231168172058 1314 870181 SGTC_178 4092-0806 87.505 µM 0.625661097430874 0.250510925495603 no 869 0.265768627504695 1300 2169044 SGTC_2784 7567673 72.73 µM 0.62524150412042 0.250654656163469 no 870 0.265906282804272 1318 3471247 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.624657956172032 0.25085462168517 no 871 0.266097786479007 1302 688669 SGTC_2435 5706476 10.6 µM 0.624582972004677 0.25088032277856 no 872 0.266122399191904 1325 5725375 SGTC_333 3486-0131 40.1 µM 0.624065622274397 0.251057684237803 no 873 0.266292244853666 1367 6744690 SGTC_2208 7283366 200 µM 0.624064300599885 0.251058137428457 no 874 0.266292678829005 1313 898663 SGTC_1433 4060-0023 7.6 µM 0.623939442497168 0.251100952133748 no 875 0.266333677933004 1328 3840627 SGTC_2594 a-mangostin 100 µM 0.623480978932346 0.251258195578626 no 876 0.266484248983706 1333 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_640 3381-0960 37.1 µM 0.621316605847257 0.252001232977728 no 877 0.267195664911942 1358 1745025 SGTC_3226 9131256 49.47 µM 0.618671751257828 0.252910793196623 no 878 0.268066311607536 1219 17178073 SGTC_3073 9114972 49.47 µM 0.616434089842498 0.253681667658582 no 879 0.268804029964305 1270 41905075 SGTC_705 1124-0212 310 µM 0.613533608304755 0.254682717000474 no 880 0.269761783745157 1337 9554485 SGTC_2760 etidronate 98.04 µM 0.610926912392712 0.255584133274305 no 881 0.270623983612294 1302 3305 A chelator and antioxidant. SGTC_1306 1185-0270 9.02 µM 0.610902971748619 0.2555924198563 no 882 0.270631908677422 1312 1548076 SGTC_185 k048-0037 25.491 µM 0.610316323578263 0.255795520397239 no 883 0.270826142879461 1329 6827589 SGTC_1160 4092-0570 10.5 µM 0.607345762084826 0.256825235583158 no 884 0.271810737383128 1316 4994975 SGTC_1800 st050079 29.0735 µM 0.605537876556117 0.257452975267319 no 885 0.272410832857052 1294 3645560 SGTC_2899 9053889 58.44 µM 0.603583096644247 0.258132615890291 no 886 0.273060426864506 1319 6470052 SGTC_979 1426-2828 121 µM 0.602692074107724 0.258442716226516 no 887 0.273356777606786 1396 747872 SGTC_1548 st061468 90.8 µM 0.602514584730621 0.258504510450293 no 888 0.273415828923428 1328 390799 SGTC_1407 3909-7909 12.3 µM 0.602410411700225 0.258540782615674 no 889 0.273450490584436 1315 4411780 SGTC_500 h-89 112 µM 0.602177100804408 0.258622029051376 no 890 0.273528128387535 1422 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1377 2944-0135 198 µM 0.601668753486275 0.258799097875872 no 891 0.273697326580273 1403 1894137 SGTC_2980 9014342 25.29 µM 0.600669332562667 0.259147401530438 no 892 0.274030124469325 1340 2996599 SGTC_221 trifluoperazine 10.304 µM 0.600426753447824 0.259231978211361 no 893 0.274110931210561 1327 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2026 5148700 152 µM 0.599080005084887 0.259701789532751 no 894 0.274559767274088 1331 79838 SGTC_1495 4469-0029 237 µM 0.598048293471823 0.260061997769963 no 895 0.274903854909907 1337 793680 SGTC_2921 7974240 10.71 µM 0.597347356230816 0.260306867453492 no 896 0.275137746674515 1375 2979074 YDR527W RBA50 SGTC_1720 st037298 9.481 µM 0.597176464724994 0.260366585739016 no 897 0.275194785344433 1351 597396 SGTC_3170 9103054 49.47 µM 0.594216483554601 0.261402074086763 no 898 0.276183664635396 1290 16432970 SGTC_1964 st076914 61 µM 0.593880172263385 0.261519859312562 no 899 0.276296130747308 1340 24208661 SGTC_3103 9120822 49.47 µM 0.593465188944913 0.261665235133994 no 900 0.276434936592466 1409 17141819 SGTC_2605 digitonin 300 nM 0.592545539225506 0.261987552028627 no 901 0.276742667775893 1402 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.591053619542219 0.262510869495673 no 902 0.277242247395097 1394 6708739 YPR165W RHO1 SGTC_2789 5281112 71.43 µM 0.590945552764871 0.262548796619675 no 903 0.277278451429343 1330 765948 SGTC_1218 1348-1416 30.7 µM 0.590630101178117 0.262659523571308 no 904 0.277384145791869 1343 6787668 SGTC_1414 3917-0015 5.4 µM 0.589426650973989 0.263082167073735 no 905 0.277787551415359 1348 6618702 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.589349769305203 0.263109179196474 no 906 0.277813332464853 1391 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2908 7930301 100 µM 0.589185895033839 0.263166760614788 no 907 0.277868289003852 1286 2223178 SGTC_779 1360-0071 233 µM 0.588123742550721 0.263540131096799 no 908 0.278224618894474 1486 7566 SGTC_207 4185-0010 4.486 µM 0.587389643395062 0.263798341346768 no 909 0.278471023912292 1401 3761753 SGTC_2846 9008642 19.48 µM 0.587098352756556 0.263900834945463 no 910 0.278568826910622 1354 2992898 SGTC_2516 gossypol 71.55 µM 0.586311828519798 0.26417768293494 no 911 0.278832991817709 1417 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_183 3914-0051 30.55 µM 0.585946251640809 0.264306412365471 no 912 0.278955817291271 1388 1596232 SGTC_198 3454-2873 16.191 µM 0.585192158760775 0.264572049555531 no 913 0.279209258365618 1332 710957 SGTC_1855 st056195 39.6 µM 0.584881255393151 0.264681608082846 no 914 0.279313781626488 1389 4028379 SGTC_321 4534-3890 65.3 µM 0.580902827889189 0.266085590750853 no 915 0.280652973171116 1391 699746 SGTC_2362 9071156 126 µM 0.580044584315832 0.266388957773318 no 916 0.280942276155828 1428 653133 SGTC_341 1486-1430 230 µM 0.579626798890697 0.26653669747509 no 917 0.281083158444706 1323 2054753 YPL210C SRP72 SGTC_635 k038-0028 24.7 µM 0.579407245829191 0.26661435370725 no 918 0.281157208065313 1416 4035102 SGTC_543 3844-1095 191 µM 0.579193534674947 0.266689954634201 no 919 0.281229296408186 1416 4230703 SGTC_112 phenothiazine 287.218 µM 0.578681597141433 0.266871098049065 no 920 0.281402017778458 1386 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2126 5251174 33.877 µM 0.578600755144886 0.266899708774513 no 921 0.281429297544343 1466 790722 SGTC_2343 7990716 14.84 µM 0.578571817580473 0.266909950421061 no 922 0.281439062704635 1403 6456862 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.577505032934815 0.267287647703484 no 923 0.281799169853893 1345 2346 DNA damaging agent; causes G2/M arrest. SGTC_2948 9070189 9.45 µM 0.575102089053341 0.26813940163726 no 924 0.282611127590944 1343 6473636 YDL196W YDL196W SGTC_549 1661-1316 519 µM 0.574922512800563 0.268203109531784 no 925 0.282671851761579 1430 2857282 SGTC_469 w7 172 µM 0.574508232398949 0.268350111977782 no 926 0.282811965656274 1403 45115570 A P450 inhibitor. SGTC_143 4032-1194 15.74 µM 0.572926259837346 0.268911828594045 no 927 0.283347311760572 1393 1806963 SGTC_11 0438-0307 1.3 µM 0.5724257799066 0.269089658628313 no 928 0.283516777376008 1428 4011476 SGTC_260 nsc-65238 3.989 µM 0.570689081169039 0.26970719803758 no 929 0.284105210773411 1378 3246252 SGTC_616 4092-0450 108 µM 0.57054914599307 0.269756987399784 no 930 0.284152649440923 1413 787165 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.569951603390684 0.269969646658668 no 931 0.284355261739593 1369 23665772 A membrane-active detergent. SGTC_2805 7950783 58.44 µM 0.569721512193142 0.270051556114277 no 932 0.284433298527505 1426 1178958 YDL195W SEC31 SGTC_2113 5491891 107.031 µM 0.568233170320297 0.270581686505971 no 933 0.284938325449737 1360 789979 SGTC_2251 lansoprazole 556 µM 0.56749254846522 0.270845681123532 no 934 0.285189793895065 1304 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2058 5236698 133 µM 0.567325153625231 0.27090536681107 no 935 0.285246645269534 1384 766665 SGTC_314 1671-0008 2.74 µM 0.56569121734424 0.271488301591698 no 936 0.285801853319377 1322 3913060 SGTC_475 α-linolenic acid 10 µM 0.565465535039707 0.271568866705759 no 937 0.285878580060532 1461 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3174 9107204 49.47 µM 0.565361743427116 0.271605922712666 no 938 0.28591387008527 1410 3938802 SGTC_2283 7944793 200 µM 0.564951547190881 0.271752396891805 no 939 0.286053360531807 1330 2970533 SGTC_707 0865-0008 204 µM 0.564460412297067 0.271927824605157 no 940 0.286220417329586 1461 723043 SGTC_188 3229-0966 278.469 µM 0.563098043098574 0.27241474181904 no 941 0.286684061983187 1495 5722370 SGTC_3133 9127736 49.47 µM 0.562508073516256 0.272625734031903 no 942 0.2868849522446 1422 27243420 SGTC_487 nimodipine 119 µM 0.56052256313686 0.273336412085537 no 943 0.287561526973911 1318 4497 L-type voltage-gated calcium channels inhibitor SGTC_2540 epiandrosterone 100 µM 0.559340061149599 0.273760103082474 no 944 0.287964829792457 1437 441302 A steroid. SGTC_3054 9094397 49.47 µM 0.5586215419021 0.274017707405212 no 945 0.28821001752622 1353 2598354 SGTC_1316 1272-0050 65.9 µM 0.558572237132841 0.274035388597221 no 946 0.288226845911156 1411 7340392 SGTC_3149 9097855 49.47 µM 0.55631198307249 0.274846543495789 no 947 0.288998798372108 1492 25236625 YMR079W SEC14 SGTC_3345 9148410 3.559 µM 0.555931064117038 0.274983363274077 no 948 0.289128990663909 1411 4903596 SGTC_2382 9035899 200 µM 0.555531731641236 0.275126832902827 no 949 0.289265506020597 1413 6462679 SGTC_615 k087-0205 167 µM 0.554912314301291 0.275349446128534 no 950 0.289477319266362 1356 9642773 SGTC_2586 curcumin 80 µM 0.554465909168268 0.275509935206836 no 951 0.289630015166909 1470 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1462 k081-0014 26.5 µM 0.554421598661609 0.275525867982278 no 952 0.289645173938513 1249 3270634 SGTC_668 1682-0499 62.6 µM 0.551858863884406 0.276448123469009 no 953 0.290522526972579 1424 682214 SGTC_983 1491-0821 12.2 µM 0.551824601921247 0.276460463624256 no 954 0.290534264986296 1442 46495113 SGTC_2205 7238770 200 µM 0.549393519024133 0.277336757349295 no 955 0.291367710392174 1438 279867 SGTC_2383 9036125 200 µM 0.545347499134988 0.278798166160766 no 956 0.292757270748153 1417 79580 SGTC_3143 9086658 49.47 µM 0.5449831680851 0.278929945029905 no 957 0.292882547057735 1453 25236626 SGTC_922 1866-0035 480 µM 0.544332791758392 0.279165262034853 no 958 0.293106242715286 1486 3156169 SGTC_2189 6047310 154.431 µM 0.543390464792216 0.27950638276796 no 959 0.293430494723823 1368 711535 SGTC_539 4859-0462 2.54 µM 0.542580699132614 0.279799678140407 no 960 0.293709265449746 1480 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2400 5203494 178.7 µM 0.542485110393772 0.279834310025052 no 961 0.293742181010221 1383 6777674 SGTC_3025 9087895 49.47 µM 0.541987818531241 0.280014512845008 no 962 0.293913448802816 1445 17173641 SGTC_2178 5812956 200 µM 0.541782334370922 0.280088990217904 no 963 0.29398423122529 1426 5403383 SGTC_200 k038-0079 37.545 µM 0.541582232768341 0.280161525917803 no 964 0.294053167110165 1441 3436683 SGTC_2051 5263410 176 µM 0.541302072348394 0.280263097777097 no 965 0.294149696163098 1440 227584 SGTC_712 r015-0009 80.6 µM 0.541134620093852 0.280323815927768 no 966 0.294207398696555 1456 6813872 YLR060W FRS1 SGTC_3136 9095672 49.47 µM 0.540066152001659 0.280711392159998 no 967 0.294575706222124 1336 17217380 SGTC_2636 apigenin dimethyl ether 100 µM 0.539433337061798 0.280941061665955 no 968 0.294793941685456 1435 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_607 4491-0986 66.8 µM 0.539412543954896 0.280948609714128 no 969 0.294801113756384 1500 698981 YDR232W HEM1 SGTC_3066 9117245 49.47 µM 0.53929850576507 0.280990008144416 no 970 0.294840449856139 1521 17176980 SGTC_3041 9091929 49.47 µM 0.539264632573776 0.281002305443273 no 971 0.294852134471447 1465 25236887 SGTC_2456 5770359 74.46 µM 0.539006695822941 0.281095955143542 no 972 0.294941117195194 1494 3118787 SGTC_2992 9074591 71.4286 µM 0.538647728631544 0.281226311288724 no 973 0.295064973873388 1426 17741321 SGTC_2021 4019055 173 µM 0.53703168833359 0.281813524991404 no 974 0.295622862745747 1431 44827708 YER133W GLC7 SGTC_1997 st073024 93.8 µM 0.534884974012277 0.282594480109102 no 975 0.296364699634937 1404 686268 SGTC_413 propylparaben 100 µM 0.529773705687401 0.284458088969904 no 976 0.29813441903252 1388 7175 A pharmaceutical preservative. SGTC_3219 9131112 49.47 µM 0.52900353032044 0.284739409184883 no 977 0.298401500446391 1404 17612988 YMR079W SEC14 SGTC_2342 7990637 118.86 µM 0.528622967135261 0.284878465639157 no 978 0.298533512331632 1481 2033102 YER133W GLC7 SGTC_2135 5326629 150.42 µM 0.528470622519016 0.284934140906926 no 979 0.298586365928903 1411 5020077 SGTC_2174 5790901 200 µM 0.528205141890057 0.285031174819787 no 980 0.298678480476321 1434 786020 SGTC_2726 cimetidine 79.27 µM 0.528108730703073 0.285066417277992 no 981 0.298711935729979 1450 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_15 0266-0086 27.098 µM 0.528018162001339 0.285099525947505 no 982 0.298743365158333 1507 1712902 YIL048W NEO1 SGTC_2409 alverine citrate 63.97 µM 0.527364201811047 0.285338644729341 no 983 0.298970349024477 1558 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3118 9124250 49.47 µM 0.527349564974714 0.285343997741907 no 984 0.298975430238497 1383 1504786 SGTC_1747 st037496 66.6 µM 0.527265782675735 0.285374639689527 no 985 0.299004516226054 1432 723305 SGTC_2103 5378138 10 µM 0.525903131769257 0.285873225914609 no 986 0.299477756431276 1486 244142 SGTC_2933 9026794 32.47 µM 0.525344368014493 0.286077794068432 no 987 0.299671909731976 1498 17586027 SGTC_2288 7946289 167.31 µM 0.524261367264451 0.286474487767183 no 988 0.300048381608011 1566 1246052 SGTC_2336 9001819 198.65 µM 0.524152277364956 0.286514460908517 no 989 0.300086315212396 1543 2989602 SGTC_2081 5214970 32.255 µM 0.524053550550748 0.286550639049162 no 990 0.300120647152446 1512 2063512 SGTC_1014 4130-3005 69.3 µM 0.523380822002792 0.286797216053188 no 991 0.300354633673067 1426 743608 SGTC_882 0843-0131 351 µM 0.522461020476759 0.287134516046347 no 992 0.300674689746667 1453 5425421 SGTC_801 0866-0028 10.1 µM 0.522204831392232 0.287228496456751 no 993 0.300763861239847 1458 6849771 SGTC_1421 4029-0249 71.4 µM 0.521797872900646 0.287377815044666 no 994 0.300905535424915 1536 2894095 SGTC_3292 9120825 59.784 µM 0.521402916571232 0.287522764979223 no 995 0.301043060075293 1509 24824900 SGTC_939 1165-0479 45.3 µM 0.520839115416606 0.287729741249609 no 996 0.301239425930426 1411 1377347 SGTC_573 3702-0553 84.7 µM 0.520676393944198 0.287789490794963 no 997 0.301296110788826 1430 1222756 SGTC_778 3456-2434 196 µM 0.520244172069431 0.287948226395558 no 998 0.301446700811613 1601 5539063 SGTC_681 1642-0006 26.6 µM 0.519586272114438 0.288189922692805 no 999 0.301675984123852 1439 4446530 SGTC_208 k072-0098 12.366 µM 0.519555891079654 0.288201086250804 no 1000 0.301686574047717 1441 5948901 SGTC_1154 4088-0362 150 µM 0.517286630572675 0.289035505605458 no 1001 0.302478042719413 1431 6618304 SGTC_1412 3909-8563 178 µM 0.516292932549726 0.28940125115685 no 1002 0.302824915802458 1542 23767530 SGTC_1002 4049-0206 172 µM 0.516004013596235 0.289507632921682 no 1003 0.302925803001561 1444 4662749 SGTC_3307 9126885 69.2785 µM 0.515607689361425 0.289653591849489 no 1004 0.303064219365784 1410 24824909 SGTC_1056 3448-1962 115 µM 0.514978419561177 0.289885411279107 no 1005 0.303284050150197 1489 715507 SGTC_1080 nisoldipine 24.4 µM 0.514595942770596 0.290026356067242 no 1006 0.303417700427118 1446 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2245 6637752 200 µM 0.514086881494717 0.290213997747254 no 1007 0.303595624394389 1558 681890 SGTC_2699 st077704 54.6 µM 0.51399605637891 0.290247482165063 no 1008 0.303627373926984 1488 645852 SGTC_2504 purpurogallin 52.29 µM 0.512775785289366 0.290697533856806 no 1009 0.304054085019895 1447 5281571 An antioxidant. SGTC_673 1082-0474 110 µM 0.512302859535794 0.290872042678903 no 1010 0.304219532133484 1441 3098046 SGTC_1406 3909-7906 11.9 µM 0.511866915460497 0.291032948682118 no 1011 0.304372077183506 1481 X1406 SGTC_2154 5570129 200 µM 0.511703422492808 0.291093304298012 no 1012 0.304429295233888 1461 673366 SGTC_1750 st081859 2.357 µM 0.511385781148864 0.291210582558282 no 1013 0.304540474668137 1487 5291695 SGTC_1608 st001473 40.5 µM 0.510940926018925 0.291374867252003 no 1014 0.304696211273353 1420 7292267 SGTC_367 0335-0881 7.1 µM 0.508446267964371 0.292296942987532 no 1015 0.305570206085569 1538 23828853 SGTC_3157 9099274 49.47 µM 0.506336592885112 0.293077778840982 no 1016 0.30631018931351 1458 17217662 SGTC_3348 9149464 3.537 µM 0.505855701876881 0.293255902199777 no 1017 0.30647897595733 1451 1951442 SGTC_562 3772-2733 112 µM 0.505841035981044 0.2932613352766 no 1018 0.306484124146153 1466 2876874 YIL048W NEO1 SGTC_58 0957-0393 9 µM 0.505449737246874 0.29340631167282 no 1019 0.306621496359543 1443 6997992 SGTC_1287 0971-0001 34.6 µM 0.503191397091804 0.294243676035891 no 1020 0.307414856342086 1497 4665869 SGTC_2563 tomatine 8.54 µM 0.502350598075863 0.294555715588993 no 1021 0.307710461534903 1611 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1886 st057356 49.9 µM 0.498650256577307 0.295930807324461 no 1022 0.30901289682566 1428 24207747 SGTC_515 4092-1064 102 µM 0.498086849621702 0.296140434477585 no 1023 0.309211414483119 1597 717353 SGTC_2849 9019321 12.99 µM 0.497091917703542 0.296510785669855 no 1024 0.30956211693526 1486 16489627 SGTC_3164 9100705 49.47 µM 0.496436015850212 0.296755053095849 no 1025 0.309793409956729 1546 17174235 SGTC_1974 st069448 26.9 µM 0.494827597983564 0.297354440994149 no 1026 0.310360910794025 1561 6323587 YNR016C ACC1 SGTC_309 k408-0051 1.48 µM 0.494408327292698 0.29751077590725 no 1027 0.310508917080399 1477 3640463 SGTC_1396 3511-0007 98.6 µM 0.493816940989817 0.297731351938792 no 1028 0.310717733868346 1467 X1396 SGTC_786 4544-0069 423 µM 0.493256129830582 0.297940592908266 no 1029 0.310915811005278 1549 748821 YLR208W SEC13 SGTC_2624 nerol 100 µM 0.492189697426185 0.298338668086067 no 1030 0.311292623480777 1575 637566 A natural product oil. SGTC_44 0929-0055 61.211 µM 0.490913017110513 0.29881554222179 no 1031 0.311743984963135 1439 1379590 SGTC_1717 st033143 58.0435 µM 0.48994334354053 0.299177972443911 no 1032 0.312086995451863 1606 674616 SGTC_938 3126-1755 342 µM 0.489647889112747 0.299288442663435 no 1033 0.312191541350397 1520 1777771 SGTC_339 3091-4833 71.4 µM 0.487657331496496 0.300033192672171 no 1034 0.312896289667447 1535 3240077 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.487113647748811 0.30023675295036 no 1035 0.313088897637772 1466 2374 Ca(2+)-ATPase inhibitor. SGTC_1271 0832-2808 169 µM 0.486003292907377 0.300652674018028 no 1036 0.313482415624042 1599 3663794 SGTC_2047 4141938 200 µM 0.485128872916878 0.300980400623783 no 1037 0.313792466075407 1519 3807862 SGTC_2122 5258151 111.688 µM 0.484312571813394 0.301286489944424 no 1038 0.314082027555946 1460 2173356 SGTC_3003 9075612 71.4286 µM 0.483993906489251 0.301406018262584 no 1039 0.314195096832249 1507 6501993 SGTC_2756 carbadox 75.1 µM 0.483789886687395 0.301482555346779 no 1040 0.314267496581698 1479 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2317 5986382 200 µM 0.481577467254086 0.302313095280203 no 1041 0.315053068103594 1646 877883 SGTC_2156 5649887 115 µM 0.480716933805139 0.302636415674196 no 1042 0.315358847102497 1601 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3198 9112019 49.47 µM 0.479747721449629 0.303000754415822 no 1043 0.315703395177034 1545 45595555 SGTC_911 3456-4043 236 µM 0.478772130005466 0.30336768921933 no 1044 0.316050372801315 1605 914281 SGTC_1453 4237-0541 195 µM 0.476290927111898 0.304301800849918 no 1045 0.316933564121412 1593 739892 SGTC_158 k038-0087 26.446 µM 0.475562395330147 0.304576318134022 no 1046 0.317193085636054 1553 X158 SGTC_1033 k072-0102 21.3 µM 0.47502240455143 0.3047798625445 no 1047 0.317385502096463 1630 5965931 SGTC_2001 4023502 57.655 µM 0.474821415275732 0.304855638986755 no 1048 0.31745713378885 1577 108941 YCR052W RSC6 SGTC_524 r073-0010 27.8 µM 0.474814090655467 0.304858400653716 no 1049 0.317459744380365 1463 2772106 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.473499968617289 0.305354055614921 no 1050 0.317928261684742 1649 5024745 SGTC_2692 st077426 47.7 µM 0.473062761906734 0.305519038588459 no 1051 0.318084201469935 1588 25238571 SGTC_2923 7992654 58.14 µM 0.472863991337351 0.305594059099771 no 1052 0.318155108212569 1518 2985126 SGTC_2284 7945075 39.21 µM 0.472387748871182 0.305773836985267 no 1053 0.31832502366253 1647 1245402 SGTC_1578 josamycin 24.2 µM 0.472009582657118 0.305916625187958 no 1054 0.318459974357719 1452 5282165 A P450 substrate. SGTC_727 3032-0951 202 µM 0.471149842698636 0.306241356021439 no 1055 0.318766866911857 1545 3652836 SGTC_1295 1013-0063 9.78 µM 0.469929913252692 0.306702394681885 no 1056 0.319202545956006 1615 6826038 SGTC_2216 7189485 200 µM 0.467467715373515 0.307633845933284 no 1057 0.320082642541134 1588 731273 SGTC_117 lucigenin 22.078 µM 0.467453304866721 0.307639301098308 no 1058 0.320087796470366 1467 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2095 5432005 200 µM 0.467337063378011 0.307683306415012 no 1059 0.320129371600854 1522 783734 SGTC_584 0986-0246 15.4 µM 0.466969719712672 0.307822389186138 no 1060 0.320260771211705 1594 53315 YDR232W HEM1 SGTC_3315 9136395 68.55 µM 0.466678236724535 0.307932769423096 no 1061 0.320365051337466 1593 16876844 SGTC_2074 5212007 75.395 µM 0.466552183521231 0.307980509264914 no 1062 0.320410152167714 1599 758611 SGTC_1321 1326-2144 215 µM 0.463882306311988 0.308992428091817 no 1063 0.321366035102951 1598 3513030 SGTC_191 3914-0123 66.505 µM 0.463609056867286 0.309096075243536 no 1064 0.321463932164142 1465 3144412 SGTC_2300 7976697 71.57 µM 0.462788978397961 0.309407233151851 no 1065 0.321757816069552 1469 2236109 SGTC_173 1273-0061 2.693 µM 0.462621609620691 0.309470753779831 no 1066 0.321817808176115 1457 2847414 YPL266W DIM1 SGTC_1375 2910-0797 186 µM 0.4623553914851 0.309571801934867 no 1067 0.321913241677964 1571 742508 SGTC_1759 st043059 70 µM 0.46231481166152 0.309587206043148 no 1068 0.321927789707838 1486 669426 SGTC_1250 0485-0349 40.2 µM 0.459427494330146 0.310684089483266 no 1069 0.322963604023068 1526 6842794 YDL195W SEC31 SGTC_2505 galangin 7.89 µM 0.459163219889597 0.310784570885647 no 1070 0.323058480277986 1480 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.459160873783777 0.31078546297611 no 1071 0.323059322596907 1610 756377 SGTC_967 1306-0166 352 µM 0.458910252097387 0.310880766538792 no 1072 0.323149308157292 1645 4437607 SGTC_2736 butenafine 14.65 µM 0.458626615303733 0.310988640015201 no 1073 0.323251160256207 1599 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_17 0960-0276 49.807 µM 0.457205089454929 0.311529522933653 no 1074 0.323761820279036 1546 6821114 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.456834129379858 0.311670738248561 no 1075 0.32389513630477 1659 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3095 9117207 49.47 µM 0.455766655321658 0.312077253678749 no 1076 0.324278892271985 1624 17015229 SGTC_1504 k297-0033 30 µM 0.455312128382821 0.312250416139579 no 1077 0.324442351007194 1477 4388117 SGTC_772 k072-0172 35.3 µM 0.454070467177638 0.312723666799929 no 1078 0.32488905437665 1448 5861980 SGTC_1346 1488-2224 62.4 µM 0.454010953958979 0.312746357618751 no 1079 0.324910471343117 1603 3722427 SGTC_252 miconazole 1.30953 nM 0.453467925479378 0.312953432808065 no 1080 0.32510591721768 1548 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2354 9060492 162 µM 0.452886945769773 0.313175045446473 no 1081 0.325315075729561 1652 6471895 SGTC_597 k018-0003 82.8 µM 0.452143542522432 0.313458712397963 no 1082 0.325582788606495 1642 6786234 SGTC_440 fluspirilene 35.1 µM 0.451170749197755 0.313830076448517 no 1083 0.325933244898172 1640 3396 An atypical antipsychotic. SGTC_2487 5918373 44.05 µM 0.450650999352739 0.314028568418233 no 1084 0.326120551859991 1597 2876279 SGTC_1683 st010134 710 nM 0.449643474675216 0.314413494364425 no 1085 0.326483767589139 1514 3818134 SGTC_3116 9124943 49.47 µM 0.449188196452344 0.314587500171277 no 1086 0.32664795078859 1466 41905195 YPL160W CDC60 SGTC_1934 st074720 32.6 µM 0.449176682581901 0.314591901268031 no 1087 0.326652103375405 1497 17250992 SGTC_54 0159-0055 9 µM 0.448192252558827 0.314968290146956 no 1088 0.327007226789974 1668 3319099 SGTC_639 0833-0042 114 µM 0.447229485222475 0.315336582429833 no 1089 0.327354687190956 1528 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1628 st004252 77.7 µM 0.44645740976684 0.315632061033949 no 1090 0.327633435484054 1674 692968 SGTC_1662 st014054 52 µM 0.446192593661247 0.315733435148206 no 1091 0.327729066203812 1525 2838777 SGTC_2847 9005661 71.43 µM 0.445693048956248 0.315924703333744 no 1092 0.327909493165611 1541 2991449 SGTC_636 0kpi-0074 126 µM 0.44273197580797 0.317059464519519 no 1093 0.328979805543906 1556 616434 SGTC_619 1652-1634 108 µM 0.442729916713361 0.317060254219325 no 1094 0.328980550315641 1556 5400454 SGTC_1176 0848-0131 83.3 µM 0.44182203073011 0.317408525948254 no 1095 0.32930899755765 1685 6769040 SGTC_2773 thioridazine 9.09 µM 0.441768013839062 0.317429252324057 no 1096 0.32932854348296 1567 5452 An antipsychotic. SGTC_3184 9108758 49.47 µM 0.441627662238378 0.317483108155133 no 1097 0.329379331664657 1567 902885 SGTC_536 3852-0578 10.6 µM 0.440454082576275 0.317933586233164 no 1098 0.329804130951953 1663 2869208 SGTC_993 3909-8757 62.7 µM 0.440264859289543 0.318006244766754 no 1099 0.329872644462686 1585 4288324 YLR208W SEC13 SGTC_1667 st014849 34.6 µM 0.439367910144941 0.318350753302617 no 1100 0.330197487264665 1583 5348460 SGTC_2761 levamisole 97.89 µM 0.438524522257064 0.318674832909003 no 1101 0.330503048906742 1690 26879 An alkaline phosphatase inhibitor. SGTC_57 miconazole 162.5 nM 0.438048898796575 0.318857656828603 no 1102 0.330675418389891 1503 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_281 1672-3440 14.9 µM 0.437118763650088 0.319215316941686 no 1103 0.331012610061572 1609 6833000 SGTC_940 3232-1287 54.8 µM 0.436068483576361 0.319619378113235 no 1104 0.331393521376179 1580 1585493 YIL048W NEO1 SGTC_897 1000-0139 31.4 µM 0.435456787380037 0.319854807117843 no 1105 0.331615449300725 1689 6151020 SGTC_1035 k081-0041 55.2 µM 0.435159207084505 0.319969365767938 no 1106 0.331723435024066 1631 731709 SGTC_2142 5622915 118.518 µM 0.434537728085567 0.320208670154766 no 1107 0.331949001966769 1545 5322196 SGTC_2236 dapsone 200 µM 0.433394401929106 0.320649110397798 no 1108 0.332364133378185 1591 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1234 0326-0494 15.5 µM 0.432832776315775 0.320865556384232 no 1109 0.332568129957376 1668 1547813 SGTC_1201 1889-3372 45.9 µM 0.431413929793351 0.321412639540103 no 1110 0.33308371157333 1578 5392199 SGTC_3270 9137563 49.47 µM 0.430957663692751 0.321588650441264 no 1111 0.33324957704652 1642 17015724 SGTC_1269 0831-0796 3.05 µM 0.430280591923632 0.321849913973548 no 1112 0.333495771654474 1649 927758 SGTC_2797 7859098 81.82 µM 0.430150719556284 0.321900038252439 no 1113 0.33354300361955 1565 972681 SGTC_1652 st011932 78 µM 0.427939046169379 0.322754131144957 no 1114 0.334347749250735 1659 1551076 SGTC_3005 9076496 71.4286 µM 0.427641579018894 0.32286907701003 no 1115 0.334456044684291 1624 21368410 SGTC_445 e6 berbamine 66 µM 0.425070033713144 0.323863466055028 no 1116 0.335392811031036 1580 6610268 A calcium/calmodulin antagonist. SGTC_3328 9140624 29.0385 µM 0.423772228941598 0.324365791571898 no 1117 0.335865966603246 1710 4904392 SGTC_1725 st036284 20.55 µM 0.422221376975929 0.324966480363591 no 1118 0.336431719809089 1744 707914 SGTC_2794 7785382 27.27 µM 0.421605275828067 0.325205240207683 no 1119 0.336656577378614 1685 2205081 SGTC_2129 girgensonine 121.053 µM 0.419634695396861 0.325969387737294 no 1120 0.337376169217577 1675 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2210 7115885 190.385 µM 0.418663125131765 0.326346410660984 no 1121 0.337731174305833 1603 2927039 SGTC_3231 9132313 49.47 µM 0.418502564730623 0.326408734065628 no 1122 0.337789855885313 1623 4905967 SGTC_1866 st057638 64 µM 0.418451021529723 0.326428742191898 no 1123 0.337808694719018 1599 688802 SGTC_1357 1503-1303 39.5 µM 0.418141990421164 0.326548712878143 no 1124 0.337921652872486 1586 292895 SGTC_2769 toremifene 3.73 µM 0.416730919688411 0.32709674033932 no 1125 0.338437617845489 1626 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3260 9137109 49.47 µM 0.415503739151082 0.327573652415301 no 1126 0.338886589237163 1685 17478346 SGTC_2242 6630449 61.2675 µM 0.41399792884043 0.328159231327396 no 1127 0.339437811829332 1624 691249 YDR170C SEC7 SGTC_1503 4585-0012 61.3 µM 0.413511701968005 0.328348405360391 no 1128 0.339615875335994 1668 2922052 SGTC_2867 9039098 71.43 µM 0.412784550498319 0.328631396939983 no 1129 0.339882235812502 1582 6463460 SGTC_1031 k035-0009 16 µM 0.412057399979032 0.328914486464926 no 1130 0.340148675902644 1735 5180959 SGTC_1247 0448-0043 5.84 µM 0.411385776709478 0.329176045700765 no 1131 0.340394840815938 1614 3089013 YGL099W LSG1 SGTC_957 1187-1561 14.1 µM 0.408732871924376 0.330210018570686 no 1132 0.341367853737382 1598 1538454 SGTC_2763 lisinopril 49.32 µM 0.408517950313475 0.330293841470156 no 1133 0.341446727407735 1630 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_644 1498-1197 63.3 µM 0.408493104497011 0.330303532289153 no 1134 0.341455845972966 1676 6741615 SGTC_3204 9114183 49.47 µM 0.407544986528928 0.330673419562307 no 1135 0.341803880119869 1572 17027248 SGTC_2447 5741742 33.78 µM 0.40669132365025 0.331006598810092 no 1136 0.342117356873293 1688 1776504 SGTC_3346 9158254 43.5805 µM 0.405291305921364 0.331553306648166 no 1137 0.342631698199462 1609 17639500 SGTC_2380 9035439 200 µM 0.404674914402948 0.331794121852506 no 1138 0.342858241961759 1700 6462575 SGTC_2533 agelasine 13.65 µM 0.402464735874937 0.332658177421371 no 1139 0.343671017977082 1781 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2758 dehydroepiandrosterone 69.35 µM 0.40046695465304 0.33343996339713 no 1140 0.344406308999348 1632 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2316 5844804 197.44 µM 0.400236290449877 0.333530275241548 no 1141 0.344491243785566 1758 776813 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.399993320264285 0.333625415675781 no 1142 0.344580718340171 1598 88881 An O-methylated flavonoid and antioxidant. SGTC_2625 euphol 100 µM 0.399166442128362 0.333949278525384 no 1143 0.344885284010344 1765 6708538 A triterpene alcohol. SGTC_1281 0884-0031 11.8 µM 0.394271470793918 0.335869015920773 no 1144 0.3466903119672 1606 1548255 SGTC_1795 st049545 62.3 µM 0.392696590365442 0.336487576080667 no 1145 0.347271794636597 1750 5291882 SGTC_2900 5328528 85.29 µM 0.391824680143452 0.33683022368427 no 1146 0.347593879061134 1580 795359 SGTC_988 1497-1057 103 µM 0.390077880900219 0.337517096870731 no 1147 0.348239479176467 1742 3533044 SGTC_943 3253-1379 105 µM 0.388994109622654 0.337943527893229 no 1148 0.348640251879265 1729 668464 SGTC_2224 6650123 117.647 µM 0.388014990334642 0.338328960460634 no 1149 0.349002470162371 1658 2908370 SGTC_2332 7982454 138.89 µM 0.386290657161001 0.339008160022046 no 1150 0.349640709528966 1619 2981748 SGTC_2567 aureobasidin a 60 nM 0.385638811681833 0.33926505269052 no 1151 0.349882092461058 1702 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2779 methotrexate 400 µM 0.385233579873792 0.339424792450642 no 1152 0.350032183224296 1650 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_554 4483-2211 187 µM 0.384291472100281 0.339796276734811 no 1153 0.350381213968943 1655 747107 SGTC_2092 5303694 80.6725 µM 0.384244709446381 0.339814719862071 no 1154 0.350398541824852 1631 1963699 SGTC_1482 3346-2049 8.48 µM 0.383944223957745 0.339933240078056 no 1155 0.350509893857263 1704 3826804 SGTC_448 monastrol 171 µM 0.383584702769166 0.340075066481443 no 1156 0.350643139850753 1672 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.383418123362744 0.340140787551013 no 1157 0.350704883857254 1687 279621 SGTC_2084 5306078 60.6385 µM 0.383093693072994 0.340268799940304 no 1158 0.350825147891003 1699 679340 SGTC_570 0987-0065 62.6 µM 0.382243381794742 0.340604399649063 no 1159 0.351140423223499 1715 3104428 SGTC_379 3970-0972 5.9 µM 0.380500277347544 0.341292760144099 no 1160 0.351787045353539 1684 2898042 YBL034C STU1 SGTC_2184 6075246 200 µM 0.380119383286833 0.341443247503769 no 1161 0.351928399010955 1693 2267320 SGTC_3114 9122766 49.47 µM 0.379049527541603 0.341866071398571 no 1162 0.352325542777467 1600 17176985 SGTC_1063 disulfiram 1.84 µM 0.378985414524065 0.341891416183257 no 1163 0.352349347447231 1659 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2308 7584454 197.62 µM 0.374380278592436 0.343713749237723 no 1164 0.354060706654155 1764 893577 SGTC_124 0136-0217 7.121 µM 0.370980382809831 0.34506148470568 no 1165 0.355326071525689 1757 3976905 SGTC_1376 2910-0861 41.3 µM 0.370214053046521 0.345365533967319 no 1166 0.355611503255137 1697 1112859 SGTC_3096 9117468 49.47 µM 0.370189926092831 0.345375108207579 no 1167 0.355620491039265 1686 41316311 SGTC_2920 7982904 15.77 µM 0.369788301410402 0.345534498479562 no 1168 0.355770116241511 1629 6456808 SGTC_1260 0700-1617 7.75 µM 0.366661277851149 0.346776435668836 no 1169 0.356935846800042 1701 2853078 SGTC_1059 3448-6867 171 µM 0.364849160796153 0.347496896285071 no 1170 0.357612002917556 1802 3934407 SGTC_1262 0737-0114 49.6 µM 0.364643550273253 0.347578677686758 no 1171 0.357688750756349 1803 765919 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.363309582628849 0.348109434297912 no 1172 0.358186817904522 1721 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1309 pyrazolanthrone 13.4 µM 0.362726071543124 0.348341694267711 no 1173 0.358404760985726 1769 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2403 6032726 181.2 µM 0.36166366209386 0.348764720313206 no 1174 0.358801692412843 1658 2881040 SGTC_3104 9120930 49.47 µM 0.361463654482194 0.348844379615962 no 1175 0.358876435202637 1697 17014836 SGTC_3090 9117696 49.47 µM 0.360727292144477 0.349137716407795 no 1176 0.35915166015751 1789 7923821 SGTC_2889 9059656 51.95 µM 0.360458339412645 0.34924487872017 no 1177 0.359252202958852 1742 3949838 SGTC_1699 st031318 29.054 µM 0.360096627132032 0.349389019370791 no 1178 0.359387437501027 1746 5340658 SGTC_3065 9113888 49.47 µM 0.359670608028889 0.34955881384729 no 1179 0.359546737233805 1757 16648368 SGTC_677 0929-0063 136 µM 0.359468406648087 0.349639413909945 no 1180 0.359622354185397 1653 1539583 SGTC_3094 9117742 49.47 µM 0.357405361567469 0.350462156944304 no 1181 0.360394181760757 1630 17149698 SGTC_2855 9016525 58.44 µM 0.355493984553131 0.351225041406184 no 1182 0.361109775326656 1662 43811474 SGTC_139 0099-0334 718.624 µM 0.352500704342898 0.352420948351945 no 1183 0.362231395167229 1764 97690 SGTC_2840 9008771 71.43 µM 0.352282071789479 0.352508356113018 no 1184 0.36231336605051 1849 2992978 SGTC_33 0986-0033 35.816 µM 0.350916135174702 0.353054624168669 no 1185 0.362825633100393 1718 2848082 SGTC_3282 9108498 15.4605 µM 0.350350257107292 0.353281020063877 no 1186 0.363037926284326 1667 16459645 SGTC_764 1951-2361 146 µM 0.350180986159866 0.353348751898508 no 1187 0.363101437666281 1638 5438930 SGTC_2364 9055074 200 µM 0.348748310377257 0.35392220657301 no 1188 0.363639136047343 1644 6470630 SGTC_2798 7813637 45.45 µM 0.347221038673627 0.354533890101781 no 1189 0.364212633180025 1757 956368 SGTC_1668 st014914 51.6 µM 0.346655447909496 0.354760508678279 no 1190 0.364425092209617 1718 2839556 SGTC_50 0929-0078 56.389 µM 0.345384977069775 0.355269743024843 no 1191 0.364902484834153 1750 1377751 SGTC_3050 9093513 49.47 µM 0.344800336921665 0.355504167355291 no 1192 0.365122239882583 1692 25236664 SGTC_1073 triclabendazole 3.09 µM 0.343142158672958 0.356169347589608 no 1193 0.365745758169604 1732 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1895 st058434 18.3 µM 0.342804320610309 0.356304925510961 no 1194 0.365872837662267 1837 5393175 SGTC_980 1473-0395 201 µM 0.342131471178422 0.356575001074977 no 1195 0.366125977207317 1685 768876 SGTC_2647 atorvastatin 60.16 µM 0.341837622093841 0.356692971965443 no 1196 0.366236547457403 1780 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1379 2144-0755 36.5 µM 0.341726396574651 0.356737628986359 no 1197 0.366278402565217 1846 5392327 SGTC_1251 0490-5699 265 µM 0.340470224019173 0.357242118174612 no 1198 0.366751221305719 1857 3883818 SGTC_3034 9090421 49.47 µM 0.3403317758519 0.357297735382074 no 1199 0.366803345074419 1828 17173761 SGTC_105 0111-0055 734.78 µM 0.33992735484402 0.357460216191977 no 1200 0.366955617902612 1729 5179370 SGTC_664 1222-0054 14.9 µM 0.336060969293215 0.359014881895151 no 1201 0.368412445208072 1720 6813991 SGTC_1491 4138-0063 26.5 µM 0.335680649341774 0.359167934479913 no 1202 0.368555849769547 1828 23883227 SGTC_1422 4031-0024 15.5 µM 0.335621573073982 0.3591917106376 no 1203 0.368578126884495 1805 782427 SGTC_1477 0139-0234 16 µM 0.334934111013563 0.359468430452261 no 1204 0.368837394936622 1759 620880 SGTC_1813 st051246 8.6015 µM 0.334646730035043 0.359584129981451 no 1205 0.368945794920217 1844 5291959 SGTC_623 k072-0108 16.9 µM 0.333226983777625 0.360155908260437 no 1206 0.369481475431675 1745 5382803 SGTC_830 4076-0286 57.8 µM 0.33237789792853 0.360498012566932 no 1207 0.369801962846048 1757 6866659 SGTC_1145 3546-0597 10.2 µM 0.332166807242684 0.36058308024515 no 1208 0.369881653063719 1737 875334 SGTC_425 3825-7017 13.1 µM 0.331993049208141 0.360653108373057 no 1209 0.369947253782417 1781 3397440 SGTC_2162 5663267 200 µM 0.331931628519988 0.360677863315082 no 1210 0.369970443493406 1825 6456493 SGTC_1498 4478-3555 97.6 µM 0.32643239827399 0.362896623288723 no 1211 0.372048614267959 1854 3437919 SGTC_257 daunorubicin 18.5 µM 0.324316198084092 0.3637516736355 no 1212 0.372849328788083 1869 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3048 9093155 49.47 µM 0.3213475500893 0.364952298996171 no 1213 0.373973512920534 1845 25236002 SGTC_2648 atorvastatin 78.68 µM 0.320603135456568 0.365253574680208 no 1214 0.374255580600608 1832 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1189 1431-2119 7.28 µM 0.320482478652718 0.365302414123255 no 1215 0.374301305262709 1755 3107275 SGTC_948 3448-0295 75.3 µM 0.320000082015708 0.365497700381256 no 1216 0.374484134190223 1720 678569 SGTC_295 k015-0027 31 µM 0.319542348465328 0.365683034647849 no 1217 0.374657641874989 1780 3887424 SGTC_3043 9092303 49.47 µM 0.319106853456471 0.365859393739157 no 1218 0.374822743417673 1683 25236084 SGTC_1112 tnp00069 1.16933 µM 0.318888843277182 0.365947690309164 no 1219 0.374905402392528 1847 145826 SGTC_152 4469-0003 551.229 µM 0.318562711788983 0.366079790477844 no 1220 0.375029066495157 1874 697280 SGTC_2271 7849410 118.62 µM 0.316308066992256 0.3669934720469 no 1221 0.37588434434315 1909 972430 SGTC_435 c-PAF 6.7 µM 0.315325821233973 0.367391757449846 no 1222 0.376257140882374 1881 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1758 st042942 75.2445 µM 0.315147446281986 0.367464101045999 no 1223 0.376324852800294 1853 669317 SGTC_744 1594-0068 283 µM 0.314719369153752 0.367637735633538 no 1224 0.376487368290207 1741 668392 SGTC_3162 9099653 49.47 µM 0.31381916653853 0.368002959735995 no 1225 0.376829193223833 1843 25237511 SGTC_753 1322-0200 289 µM 0.313580212119396 0.368099926762152 no 1226 0.376919945226053 1771 5403907 SGTC_819 1013-0258 27.7 µM 0.313082195390283 0.368302047544137 no 1227 0.377109107815129 1749 5753198 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.312586861041416 0.368503115839142 no 1228 0.377297280809653 1734 2724 A muscle relaxant with antifungal properties. SGTC_1660 st012960 28.1 µM 0.312496616322276 0.368539752251701 no 1229 0.377331567093251 1766 24207266 SGTC_1996 st072960 66.8 µM 0.31247517999109 0.368548454878657 no 1230 0.377339711447443 1883 1719405 SGTC_2013 4024628 200 µM 0.312060086257095 0.36871698608623 no 1231 0.37749742970839 1799 5230760 SGTC_3089 9117425 49.47 µM 0.311051667842392 0.369126516749675 no 1232 0.377880671596981 1705 9401657 SGTC_3033 9090887 49.47 µM 0.310644147985032 0.369292057576581 no 1233 0.378035580606755 1713 19325384 SGTC_1678 st019265 80.2 µM 0.310394854966373 0.369393336182493 no 1234 0.378130353105582 1916 5367020 SGTC_275 trichlorophene 5.69 µM 0.309715821883052 0.369669248361136 no 1235 0.378388534945606 1788 62616 SGTC_1479 0549-0158 134 µM 0.306964662918085 0.370787815011021 no 1236 0.379435134713903 1755 5440202 SGTC_2829 7992743 58.44 µM 0.306433869129857 0.371003751297992 no 1237 0.379637162013745 1960 16462845 SGTC_1691 st019933 84.6 µM 0.305297934750253 0.371466005888355 no 1238 0.380069624366208 1904 6176082 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.302360953760852 0.372662032428706 no 1239 0.381188458458823 1777 4620898 SGTC_1930 st074634 34.3 µM 0.30127532988251 0.373104442635002 no 1240 0.381602275700278 1687 684253 YOR116C RPO31 SGTC_3281 9140613 49.47 µM 0.300989627147925 0.373220899205265 no 1241 0.381711202158533 1688 16013766 SGTC_954 1189-0853 2.85 µM 0.299945300880965 0.37364668018366 no 1242 0.382109439559721 1815 2828194 SGTC_1789 tunicamycin 25 nM 0.299924253240808 0.373655263078784 no 1243 0.382117467030275 1900 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_884 0851-0618 334 µM 0.299445462244883 0.373850523400577 no 1244 0.382300089336403 1898 9642473 SGTC_1060 3448-7350 82 µM 0.297308478368928 0.374722421295292 no 1245 0.383115504670127 1896 570178 SGTC_1401 3807-4679 7.6 µM 0.29695568711622 0.374866423271688 no 1246 0.383250170214405 1773 3291456 SGTC_1248 0469-0687 58.6 µM 0.295860159506646 0.375313705757245 no 1247 0.383668438874729 1843 4017482 SGTC_1484 3473-2379 286 µM 0.295695976228106 0.375380753039951 no 1248 0.383731135178129 1831 671917 SGTC_199 4063-0024 41.6 µM 0.295476792850228 0.37547026649901 no 1249 0.38381483899104 1870 306215 SGTC_2070 5230947 200 µM 0.29405721845851 0.376050176129246 no 1250 0.384357090524598 1900 2835538 SGTC_1028 k015-0029 4.8 µM 0.292648822064604 0.376625796170003 no 1251 0.384895296004888 1753 4588309 SGTC_2711 st079103 59.1 µM 0.292067178843389 0.3768635973789 no 1252 0.385117630301868 1893 54693780 SGTC_1946 st076057 65.1 µM 0.290851447048243 0.377360792544891 no 1253 0.385582468144798 1788 953009 SGTC_3290 9121031 71.43 µM 0.29009641006365 0.377669680778834 no 1254 0.385871241062608 1753 17014854 SGTC_2397 5161689 200 µM 0.290031044489573 0.377696425743701 no 1255 0.385896243884979 1857 2259942 SGTC_809 3998-0021 90 µM 0.28983707976946 0.37777579175985 no 1256 0.385970439635105 1910 715485 SGTC_1948 st076329 66.6 µM 0.288728406253078 0.378229535058254 no 1257 0.386394611500733 1854 24208413 SGTC_2249 haloperidol 116.36 µM 0.28681888210853 0.379011433486611 no 1258 0.387125502139309 1840 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_944 3370-0224 231 µM 0.286044688192652 0.379328586237087 no 1259 0.387421947298162 1740 4580514 SGTC_2827 7993847 71.43 µM 0.284882487356545 0.379804840570047 no 1260 0.387867086677084 1814 2985692 SGTC_459 nigericin 15.3 µM 0.284542359417579 0.379944254970916 no 1261 0.387997388401502 1823 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3006 9075424 71.4286 µM 0.284221389479662 0.380075831045242 no 1262 0.388120362334368 1753 7465181 SGTC_1902 st060212 70.5 µM 0.282853029401358 0.380636922151447 no 1263 0.388644750927362 1838 688944 SGTC_899 1083-0020 478 µM 0.278802254462372 0.382299395957486 no 1264 0.390198292112285 1925 767123 SGTC_1443 4112-3303 14 µM 0.278548442495122 0.382403635256135 no 1265 0.390295692013443 1804 704433 SGTC_3337 9144342 33.5465 µM 0.278533389710428 0.382409817626883 no 1266 0.390301468709769 1887 17682949 SGTC_1635 st007035 42.4 µM 0.277745060694544 0.382733636266621 no 1267 0.390604033750236 1804 3716403 SGTC_3339 9145883 14.936 µM 0.277641340134383 0.382776247239279 no 1268 0.390643847211227 1907 2030670 SGTC_2645 abamectin 100 µM 0.27761999224341 0.382785017657234 no 1269 0.390652041808146 1895 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3196 9111891 49.47 µM 0.27742897154066 0.382863497938978 no 1270 0.390725369135888 1832 18891510 SGTC_2752 diclazuril 33.15 µM 0.277252610431858 0.382935959640566 no 1271 0.390793072519356 1927 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_914 3820-6779 408 µM 0.277191313326458 0.382961145815833 no 1272 0.390816604681331 1774 2893481 SGTC_1624 st003710 6.25 µM 0.276999492453272 0.383039965689206 no 1273 0.390890247933513 1910 24207033 SGTC_1016 4226-1401 38 µM 0.276997323472701 0.383040856958668 no 1274 0.39089108066393 1845 2901613 SGTC_1958 st076513 41.9 µM 0.27630140077576 0.383326854881952 no 1275 0.391158290058384 1792 732122 YGL099W LSG1 SGTC_1299 1079-1439 3.74 µM 0.274209462365967 0.384186944819037 no 1276 0.391961828402892 1785 323161 SGTC_167 3672-0051 66.205 µM 0.272295903976694 0.384974194565726 no 1277 0.392697252716428 1783 3237971 SGTC_2022 5136654 200 µM 0.271117300084067 0.385459315790261 no 1278 0.393150408087669 1837 1713771 SGTC_1646 st011709 75.6 µM 0.270822351606879 0.385580746624226 no 1279 0.393263833995312 1945 5757843 SGTC_2269 7935389 174.42 µM 0.269958630811205 0.385936406545873 no 1280 0.393596040073087 1758 97605 SGTC_3098 9119039 49.47 µM 0.267865825118906 0.386798571879133 no 1281 0.394401300136613 1821 17161528 SGTC_159 3970-0959 50 µM 0.267529823184403 0.386937045523785 no 1282 0.394530627555195 1930 6615653 SGTC_2395 5646831 180.19 µM 0.267240051364221 0.387056478300412 no 1283 0.394642170302075 1875 6808628 SGTC_2150 5556613 200 µM 0.265922679075377 0.38759958305092 no 1284 0.395149379191143 1868 743190 SGTC_2677 mitomycin C 100 µM 0.265356944202922 0.387832882583642 no 1285 0.395367250539814 1841 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1518 st038567 90.8 µM 0.265035489341563 0.387965463202343 no 1286 0.395491061276158 1864 77966 SGTC_3333 9141820 12.094 µM 0.263755876202921 0.388493355280815 no 1287 0.395984018271947 1805 1939433 SGTC_338 4055-0136 114 µM 0.26363322612666 0.388543964223845 no 1288 0.396031276626325 1792 2900563 SGTC_702 1488-0190 94 µM 0.263534990585577 0.388584500393288 no 1289 0.396069128907644 1976 949357 SGTC_650 1328-0195 38 µM 0.262978880723745 0.388813997878534 no 1290 0.396283428546161 1946 2780821 SGTC_2915 7971052 15.16 µM 0.26287209980158 0.388858069070056 no 1291 0.396324580682382 1933 5741558 SGTC_2819 7996655 46.38 µM 0.262552918643539 0.388989811744632 no 1292 0.396447596305772 1923 6456960 SGTC_2116 5511452 16.8835 µM 0.261942785191353 0.389241681083282 no 1293 0.396682776544092 1868 870744 SGTC_634 1611-4317 11.2 µM 0.26022281458051 0.389951952785889 no 1294 0.397345953409996 1983 2843522 SGTC_942 3253-1115 227 µM 0.259695277918489 0.390169875843362 no 1295 0.397549417691277 1937 46497897 SGTC_3319 9138450 16.7555 µM 0.259532367389141 0.39023718044021 no 1296 0.397612255877384 1840 2029690 SGTC_248 streptozotocin 5.23457 mM 0.258384781865216 0.390711385205983 no 1297 0.398054980126493 1978 5300 DNA alkylating agent. SGTC_1298 1079-1278 263 µM 0.258314317732991 0.390740507667534 no 1298 0.39808216859793 1848 2840950 SGTC_7 0192-1582 4.227 µM 0.258117642879223 0.390821795609757 no 1299 0.398158057890057 1877 252616 SGTC_741 4582-0002 126 µM 0.258099274564144 0.390829387685848 no 1300 0.39816514571597 1815 2912688 SGTC_1192 1488-0095 21.4 µM 0.257992644824498 0.390873461199903 no 1301 0.398206291853686 1871 915875 SGTC_1898 st060199 18.6 µM 0.256476465122568 0.391500298638275 no 1302 0.398791475466056 1807 688866 SGTC_2848 9016370 25.97 µM 0.255947107854454 0.391719218417491 no 1303 0.398995839479851 2009 7894410 SGTC_2831 7999036 19.48 µM 0.25554408591221 0.391885914245773 no 1304 0.399151448964159 1983 2988270 SGTC_441 propafenone 146 µM 0.254403250354163 0.392357888204473 no 1305 0.399592020068168 1851 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.253961055796553 0.392540870711132 no 1306 0.399762822434647 1901 4000243 SGTC_2405 ticlatone 3.52 µM 0.252693856125386 0.393065376270164 no 1307 0.400252397972186 1629 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1525 8-methoxypsoralen 92.5 µM 0.25184180454032 0.393418157475412 no 1308 0.400581671560365 2008 4114 Related to psoralen; DNA damaging agent. SGTC_3022 9087993 49.47 µM 0.251168430644616 0.393697021369637 no 1309 0.400841945522834 1907 17173644 SGTC_2808 7946468 45.46 µM 0.249746146020828 0.394286210234485 no 1310 0.401391834670858 1891 2970879 SGTC_1600 coumarin 106 71.1 µM 0.24881452058457 0.394672272204027 no 1311 0.401752129235527 1885 100336 A hepatotoxic, DNA x-linker. SGTC_2311 7694451 200 µM 0.246919428628558 0.395457909877043 no 1312 0.402485289961821 1899 2163142 SGTC_2845 9003024 42.97 µM 0.246368811330229 0.395686256042679 no 1313 0.402698373610074 1949 2990173 SGTC_337 1315-0038 354 µM 0.246024493745934 0.395829065982289 no 1314 0.402831635928924 1868 1626437 SGTC_2478 5763493 32.33 µM 0.245495606151067 0.396048455829718 no 1315 0.40303635494343 1910 1365576 YLR208W SEC13 SGTC_3021 9087658 49.47 µM 0.244386585256016 0.396508599793115 no 1316 0.403465715136251 1997 25237042 SGTC_1489 4065-0444 182 µM 0.243978405960666 0.39667799383492 no 1317 0.403623772091124 1993 2877968 SGTC_2681 menadione 3.18 µM 0.243792935022456 0.396754970553657 no 1318 0.403695596154021 1902 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1927 st060202 13.8 µM 0.242552163383152 0.397270036145015 no 1319 0.404176171352632 1999 688887 SGTC_1798 st045719 60.953 µM 0.242534905413569 0.397277201489883 no 1320 0.404182856724427 1964 3980186 SGTC_964 1287-0107 19.4 µM 0.242153816863836 0.397435434662992 no 1321 0.404330489482917 1967 51516812 YPR165W RHO1 SGTC_898 1000-0849 28.3 µM 0.241862480057539 0.39755641307195 no 1322 0.404443361828988 2004 6751807 SGTC_545 4218-0007 221 µM 0.240349883344396 0.398184681156604 no 1323 0.405029513401335 1891 2840508 SGTC_2608 thymoquinone 42.66 µM 0.240297860774034 0.398206293817098 no 1324 0.405049676645573 1972 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1818 st052136 56.3 µM 0.240228550672269 0.398235089029049 no 1325 0.405076540694639 1884 674169 SGTC_2733 amorolfine 100 µM 0.239679148846736 0.398463360229878 no 1326 0.405289500326585 2038 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3255 9139072 49.47 µM 0.236847038454368 0.399640624585154 no 1327 0.406387729078093 1897 17646060 SGTC_1359 1582-0056 520 nM 0.236758473004526 0.399677454645865 no 1328 0.406422084694783 1933 3661189 SGTC_2337 9009472 200 µM 0.234624793789317 0.40056501707087 no 1329 0.407249981995947 1993 5742383 SGTC_647 0140-0236 81 µM 0.233820661698932 0.400899651403572 no 1330 0.407562104217062 1925 990837 SGTC_1164 k060-0068 93.7 µM 0.233155939523386 0.401176326128017 no 1331 0.407820159084901 1925 5963676 SGTC_1994 st072947 40.9 µM 0.232387841998681 0.401496090090294 no 1332 0.408118395579367 1919 5286565 YDL195W SEC31 SGTC_256 clotrimazole 625 nM 0.230955617546211 0.402092510430515 no 1333 0.408674640980887 1914 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1183 1254-0324 198 µM 0.230163111060551 0.402422631510821 no 1334 0.408982512737397 1966 5799357 SGTC_3268 9137683 49.47 µM 0.230083709456386 0.402455710339706 no 1335 0.409013361654453 1875 1953228 SGTC_1280 0880-0253 10.1 µM 0.22977672490395 0.402583607138752 no 1336 0.409132635841932 1898 6836607 SGTC_845 0330-0138 4.51 µM 0.229523771611244 0.402689001113232 no 1337 0.409230923326851 2004 9039800 SGTC_1240 0356-0016 42.1 µM 0.22678048799666 0.403832453619248 no 1338 0.410297218382129 1924 4305613 SGTC_785 1270-0111 65.3 µM 0.226230076868468 0.404061974750925 no 1339 0.410511239488513 1952 6741994 SGTC_814 3342-0569 96 µM 0.22620111069631 0.404074054544052 no 1340 0.410522503393802 1936 4346283 SGTC_2775 cyproheptadine 69.59 µM 0.226039491878091 0.404141456287892 no 1341 0.410585352509137 2035 2913 A selective serotonin reuptake inhibitor. SGTC_1973 st070275 50.2 µM 0.225779136765019 0.40425004114163 no 1342 0.410686602283109 2019 17118334 SGTC_743 1275-0778 158 µM 0.225491316222901 0.404370089433531 no 1343 0.41079854004328 2001 2849257 YMR203W TOM40 SGTC_163 TUB2.036 7.546 µM 0.224380432284535 0.404833517082123 no 1344 0.411230647656751 2022 15992207 YJR013W GPI14 SGTC_3038 9091290 49.47 µM 0.222897496453506 0.40545236165439 no 1345 0.411807642458897 1993 25236843 SGTC_2644 guaiazulene 100 µM 0.222716209863832 0.405528030685713 no 1346 0.411878192281656 2011 3515 A coloring agent. SGTC_567 1080-0542 68.4 µM 0.222093239345495 0.405788085507054 no 1347 0.412120650334205 2016 5950415 SGTC_2347 9049783 174.81 µM 0.221054359332442 0.406221851368485 no 1348 0.412525053554833 1978 6467988 YPL169C MEX67 SGTC_2298 7976326 193.81 µM 0.220763801284606 0.406343189335678 no 1349 0.412638175277345 1984 2235818 SGTC_19 0279-0214 38.434 µM 0.220078661376502 0.406629341536856 no 1350 0.412904946581173 1945 3566274 YBR002C RER2 SGTC_2328 6201408 200 µM 0.219350796580604 0.406933392630476 no 1351 0.413188397639855 1882 2890418 SGTC_2743 auranofin 4.32 µM 0.218433260239768 0.407316755167747 no 1352 0.413545776610453 1988 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_509 pifithrin 175 µM 0.217086091848928 0.407879786199923 no 1353 0.414070626310963 1999 4817 A p53 inhibitor. SGTC_1405 3909-7894 12 µM 0.216804551545485 0.407997476287445 no 1354 0.414180332352447 2014 7104060 SGTC_2925 9010536 32.5 µM 0.21586872245149 0.40838873319257 no 1355 0.41454503907461 1960 2994177 SGTC_2935 9038016 29.96 µM 0.215683667702102 0.408466112794581 no 1356 0.414617166439004 2045 6463195 SGTC_2664 lyso-paf C-16 73.48 µM 0.215596636358698 0.408502505695133 no 1357 0.414651088970913 1942 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2429 5902844 64.44 µM 0.214122743758523 0.409118946082848 no 1358 0.415225670065714 2037 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_402 epigallocatechin gallate 10 µM 0.212392101328287 0.409843056331684 no 1359 0.415900573721864 1895 65064 An antioxidant. SGTC_1102 cgs 12066b 26.1 µM 0.21218036865314 0.409931667607073 no 1360 0.41598316080212 1932 6438352 A 5-HT1B full agonist. SGTC_1832 st054113 55 µM 0.210477453694263 0.410644513674941 no 1361 0.416647523439057 2053 1251267 SGTC_1951 sophoraflavanone G 9.2 µM 0.209559621877402 0.411028843843331 no 1362 0.417005698444128 1825 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1852 st056254 31.4 µM 0.209038090060216 0.411247266609378 no 1363 0.417209251916504 1963 442583 SGTC_965 1291-5240 308 µM 0.208875837002078 0.411315225435381 no 1364 0.417272583690569 2012 2834598 SGTC_2662 daunorubicin 22.37 µM 0.208595069457362 0.411432829706173 no 1365 0.417382179956385 1994 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1924 st058459 75.1 µM 0.207145669520944 0.41204006192789 no 1366 0.4179480481913 1983 688683 SGTC_2514 salinomycin 42.74 µM 0.206934626360512 0.412128496955769 no 1367 0.41803045691636 2070 23682228 A polyether potassium ionophore. SGTC_2124 5246320 200 µM 0.206584528924563 0.412275210798309 no 1368 0.41816717188048 1944 579342 SGTC_2048 5246248 200 µM 0.206164166862468 0.412451386335065 no 1369 0.418331338628343 2057 677046 SGTC_670 4204-0025 119 µM 0.206091628221681 0.412481789375136 no 1370 0.418359669058791 2007 719039 SGTC_2606 farnesol 9.78 µM 0.205743328585005 0.412627779126742 no 1371 0.418495705607785 2040 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1398 3558-0053 112 µM 0.205556662303522 0.412706025252832 no 1372 0.418568616492396 1930 4532369 SGTC_1037 k284-1091 78.7 µM 0.204685450203697 0.41307126275406 no 1373 0.418908944395194 1898 3334711 SGTC_1522 st012842 45.6 µM 0.204537944615089 0.413133108853291 no 1374 0.418966571588166 1849 3491067 YOR116C RPO31 SGTC_2231 micatex 6.853 µM 0.20445774735127 0.413166734842934 no 1375 0.418997903627013 1989 20737 An antifungal of unknown mechanism. SGTC_4 0960-0234 25.671 µM 0.204243373089704 0.413256623164577 no 1376 0.419081659413655 1930 6821112 SGTC_2468 5987765 72.9 µM 0.202243981645987 0.414095197497134 no 1377 0.41986299554728 1987 26772094 SGTC_2453 5731132 22.18 µM 0.200799241688488 0.414701386876063 no 1378 0.420427777949142 2056 1362040 SGTC_3011 9081274 71.4286 µM 0.200678225864448 0.414752172389186 no 1379 0.420475093298842 1931 6625322 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.200183694786731 0.414959722151654 no 1380 0.420668459376538 1976 5393153 SGTC_3126 9127922 49.47 µM 0.199940281817433 0.415061888868959 no 1381 0.42076364305933 1981 45595682 SGTC_1078 idebenone 36.1 µM 0.199695163761954 0.415164777059875 no 1382 0.420859498176641 1987 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1962 st076595 64.5 µM 0.197559481224879 0.416061474269706 no 1383 0.421694869597788 1946 279619 SGTC_177 1327-0068 8.361 µM 0.196623569067662 0.416454568561503 no 1384 0.42206106259896 2045 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1929 genistein trimethyl ether 50.5 µM 0.196179643424822 0.416641051882121 no 1385 0.422234780328992 2106 136420 SGTC_3061 glucosamine 200 µM 0.195800367079105 0.416800392330189 no 1386 0.422383211373508 2070 91431 and experimental redox chemotherapeutic SGTC_3322 9139058 2.11 µM 0.195033051362006 0.417122796498468 no 1387 0.422683536589468 2026 4908926 YPR165W RHO1 SGTC_294 k038-0071 157 µM 0.194872544505911 0.417190243955422 no 1388 0.422746364212114 1948 24152826 SGTC_1514 1189-1591 158 µM 0.194646735647527 0.4172851364466 no 1389 0.422834756496762 2043 767698 YMR146C TIF34 SGTC_1778 st046819 58.9 µM 0.1924622392896 0.418203383383602 no 1390 0.423690071808625 1927 671715 SGTC_1703 st026983 48.3 µM 0.192154917978315 0.418332600939131 no 1391 0.423810429008285 2081 1104023 SGTC_2266 7929956 200 µM 0.191944135116175 0.418421232646649 no 1392 0.423892982665211 2059 2967153 SGTC_1733 st037357 54.9 µM 0.190366670089084 0.419084669281586 no 1393 0.424510906742277 1835 1272339 YGL099W LSG1 SGTC_179 1273-0063 6.77 µM 0.189653069821377 0.419384864845852 no 1394 0.424790499058152 1943 3108139 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.189015839276932 0.419652973057391 no 1395 0.425040201304877 1939 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_493 zm226600 134 µM 0.188379698196227 0.41992066009433 no 1396 0.425289506639902 2028 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1136 pergolide 1.05886 µM 0.187764657072759 0.420179503538617 no 1397 0.425530571255626 1934 47811 A dopamine receptor agonist. SGTC_921 1561-0023 372 µM 0.185423602507382 0.421165064147717 no 1398 0.426448398639138 1981 24050882 SGTC_1202 1988-0068 29.6 µM 0.184026584087229 0.421753430812131 no 1399 0.426996299989349 1893 2850480 SGTC_769 0302-0231 76 µM 0.181991555800685 0.422610813259959 no 1400 0.427794676367424 2062 571869 YER009W NTF2 SGTC_3173 9105693 49.47 µM 0.181112069715023 0.422981465310708 no 1401 0.428139805501472 2031 17096658 SGTC_577 r071-0003 38.6 µM 0.177756627618075 0.424396211892699 no 1402 0.429457055467529 2034 4568517 YMR134W ERG29 SGTC_3331 9141060 1.957 µM 0.176748851781473 0.424821309030033 no 1403 0.429852833368792 1945 4906567 YPR165W RHO1 SGTC_1872 amphotericin b 148 nM 0.176515378712109 0.42491980446985 no 1404 0.42994453395284 2068 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2771 fluoxetine 41.05 µM 0.174288015381706 0.42585969853525 no 1405 0.430819558719438 2065 3386 A selective serotonin reuptake inhibitor. SGTC_1664 st014217 9.02 µM 0.174136662848166 0.42592358103448 no 1406 0.430879030282778 2140 3982782 SGTC_274 sirtinol 40.1 µM 0.173611513159105 0.426145249968332 no 1407 0.431085391620823 1912 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2767 sibutramine 71.45 µM 0.173271669800736 0.426288712395167 no 1408 0.431218945537971 2103 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1786 berberine 21.6 µM 0.173051556180687 0.426381636981264 no 1409 0.431305451458804 2054 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2557 derrustone 83.84 µM 0.172508862985053 0.426610761292459 no 1410 0.431518747080227 1907 629853 An antioxidant. SGTC_1539 benzyladenosine 56 µM 0.172400556424704 0.426656491138626 no 1411 0.431561317382514 2010 92208 A nucleotide analog. SGTC_1308 1187-1617 41.4 µM 0.172301074907563 0.426698495690771 no 1412 0.431600419668645 1994 2882570 SGTC_590 k048-0076 22.4 µM 0.170846904919494 0.427312591422668 no 1413 0.432172073218707 2106 6832814 SGTC_2620 irigenin 100 µM 0.169490156596126 0.427885704900105 no 1414 0.432705557125558 2063 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_387 norethindrone acetate 66.7 µM 0.167560491698097 0.428701089897958 no 1415 0.433464527362015 1983 541197 SGTC_2159 5658611 73.75 µM 0.166081396667164 0.429326291694841 no 1416 0.43404644706953 2114 793844 SGTC_1139 k015-0024 46.9 µM 0.166044259163314 0.429341991713163 no 1417 0.434061059906396 2132 2766652 SGTC_2597 laccaic acid a 100 µM 0.1656663148594 0.429501775430219 no 1418 0.434209778266038 1997 5491415 A textile dye. SGTC_1661 st013063 9.66 µM 0.16532846230788 0.429644619313549 no 1419 0.434342728693322 2029 721395 SGTC_2439 5492030 7.2 µM 0.164920615361489 0.429817069060554 no 1420 0.434503232935947 2120 5722370 SGTC_629 3448-6466 76.7 µM 0.164737867266849 0.429894344704353 no 1421 0.434575155194875 2042 573744 SGTC_1352 1496-0991 99 µM 0.163928858483038 0.430236468999568 no 1422 0.434893574310221 2013 3000039 SGTC_70 0141-0289 43.283 µM 0.16301016771992 0.430625040557931 no 1423 0.435255214535441 2018 352408 SGTC_2896 9052656 71.43 µM 0.16292964088759 0.43065910357988 no 1424 0.435286916299295 2089 6469436 SGTC_2315 7733312 200 µM 0.162903822037318 0.430670025117888 no 1425 0.435297080739674 1989 726316 SGTC_3172 9105863 49.47 µM 0.159189250178607 0.432241861209015 no 1426 0.436759886489925 2116 2348785 SGTC_1688 st021091 57.6 µM 0.158737115999575 0.432433257366475 no 1427 0.436937997285508 2156 3656366 SGTC_2560 caryophyllene 100 µM 0.157542755469361 0.432938926825898 no 1428 0.437408557292275 2149 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_363 0455-0021 3.06 µM 0.157032188435028 0.433155124724931 no 1429 0.43760974004689 2054 4597466 SGTC_2461 5755302 26.15 µM 0.156256121834589 0.433483785822807 no 1430 0.437915570565711 2141 2788904 SGTC_1567 st069303 68.4 µM 0.155656687185236 0.433737675497314 no 1431 0.438151819773259 2009 5581319 SGTC_35 0133-0054 64.071 µM 0.155028384578196 0.434003821501159 no 1432 0.43839947008251 1992 99677 SGTC_795 0685-0265 78 µM 0.15485956790639 0.434075336547213 no 1433 0.438466014588822 2168 302754 SGTC_1222 0366-0074 1.18 µM 0.154417884695369 0.434262455018134 no 1434 0.438640126419705 2143 286520 SGTC_3141 9094609 49.47 µM 0.149545104867941 0.436327769827032 no 1435 0.440561760473244 1920 25236309 YDL196W YDL196W SGTC_64 000l-0018 272.079 µM 0.148354766006723 0.436832557968986 no 1436 0.441031398231455 1952 6811119 SGTC_1354 1498-1681 81 µM 0.147561106934627 0.437169182943539 no 1437 0.441344575584885 2034 5754243 SGTC_719 2810-4230 27.3 µM 0.147172189080672 0.437334156369319 no 1438 0.441498055719908 2102 721079 SGTC_2712 st079126 47.7 µM 0.147165859730137 0.437336841280035 no 1439 0.441500553568344 2078 3152970 SGTC_1062 mesoridazine 14.2 µM 0.146759444344532 0.437509248737003 no 1440 0.441660948356698 2133 4078 A neuroleptic. SGTC_3317 9138495 8.753 µM 0.145772510789181 0.437927969974145 no 1441 0.442050488637377 2170 17020139 SGTC_2740 felodipine 17.08 µM 0.145673340370819 0.437970048349847 no 1442 0.442089634065952 2146 3333 L-type calcium channel blocker SGTC_382 3229-0966 23.2 µM 0.145244301268094 0.4381520993048 no 1443 0.442258994703001 2143 5722370 SGTC_2960 9079389 5.97 µM 0.144391072592584 0.438514182313235 no 1444 0.442595832988864 2139 16457355 SGTC_2626 ethyl orsellinate 100 µM 0.142781214038889 0.43919749481908 no 1445 0.443231487039642 2064 75653 A natural product. SGTC_1104 tacrolimus 29.8 µM 0.142269984890148 0.439414526594731 no 1446 0.443433376960889 2128 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_913 3487-1245 167 µM 0.142247254551766 0.439424176713745 no 1447 0.443442353758759 2040 4016153 SGTC_3293 9120939 62.045 µM 0.141717961098058 0.439648897341591 no 1448 0.443651393615492 2098 934087 SGTC_2904 7225135 42.03 µM 0.14152001168975 0.439732945163626 no 1449 0.44372957604854 2160 4446116 SGTC_1311 1190-0148 100 µM 0.140946184207792 0.439976603310616 no 1450 0.443956228287638 2135 1961333 SGTC_2264 7948757 110.76 µM 0.140821871169892 0.440029392008459 no 1451 0.444005332272772 2022 2971411 SGTC_1273 0849-0096 14.1 µM 0.14074939802127 0.440060167736977 no 1452 0.44403395975858 2038 5286025 SGTC_866 0495-0101 262 µM 0.140598250328467 0.440124353782212 no 1453 0.444093665271525 1941 635694 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.138783075246568 0.440895304467626 no 1454 0.444810784272466 2024 442882 SGTC_972 1319-0219 195 µM 0.138481814450264 0.441023279291399 no 1455 0.444929820550992 2034 23903702 SGTC_2483 5729050 27.16 µM 0.136940079214635 0.441678300644187 no 1456 0.445539079301191 2154 2865180 SGTC_2852 9023854 51.95 µM 0.136298302260701 0.441951013012791 no 1457 0.445792732980119 2109 19798528 SGTC_2493 resveratrol 26.09 µM 0.135024887175036 0.442492210770867 no 1458 0.446296098698692 2086 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2788 5282734 71.43 µM 0.134742069301224 0.442612422157982 no 1459 0.446407904988903 2145 743706 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.13349571563032 0.443142246044597 no 1460 0.446900676188766 2082 521171 SGTC_758 0868-0029 16 µM 0.132863094761227 0.443411211600631 no 1461 0.447150827098119 2196 762687 SGTC_3113 9123498 49.47 µM 0.129840387659809 0.444696705785563 no 1462 0.448346354315009 2203 8897275 SGTC_3156 9099931 49.47 µM 0.129457110286663 0.444859747495147 no 1463 0.448497980169174 2088 18111053 SGTC_1486 3970-0793 4.53 µM 0.129293395290771 0.444929392783733 no 1464 0.448562748682112 2190 2844330 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.128349284621169 0.445331055925018 no 1465 0.448936282056167 2080 115019 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.127813654927046 0.445558959598718 no 1466 0.449148221814762 2096 6708514 SGTC_2989 9073649 71.4286 µM 0.12751372423809 0.445686584183565 no 1467 0.449266905739577 2215 21367202 SGTC_526 4469-0568 170 µM 0.12642662364963 0.446149207333262 no 1468 0.449697114304729 2043 2901964 SGTC_1232 0279-0259 161 µM 0.125534499487621 0.446528911719584 no 1469 0.450050207206872 2047 1560000 SGTC_23 0213-0011 39.996 µM 0.124718283524472 0.446876351145728 no 1470 0.450373291129941 2185 627608 SGTC_332 4112-0506 40.9 µM 0.124710886717742 0.446879499938341 no 1471 0.450376219169149 2080 2790355 SGTC_2017 5132927 60.65 µM 0.122323361489989 0.447896034276891 no 1472 0.451321465566865 2108 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2932 9016711 44.54 µM 0.121343204383022 0.448313454316683 no 1473 0.451709600336989 2194 7117328 SGTC_2066 5222451 176 µM 0.121221595527872 0.448365247946226 no 1474 0.451757759746732 2187 2281147 SGTC_42 0133-0086 60.653 µM 0.121104134880129 0.44841527567561 no 1475 0.451804277061828 2172 162923 Model of phenazepam hydroxylation. SGTC_2053 5265679 138 µM 0.12066583060414 0.448601961327494 no 1476 0.451977862207578 2140 764595 SGTC_3216 9129716 49.47 µM 0.120360474325305 0.448732027558956 no 1477 0.452098800323392 2113 8056934 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.119526390909293 0.449087332679389 no 1478 0.452429166492039 2136 688761 SGTC_1552 6-methylflavone 10.6 µM 0.118024378131928 0.449727266945487 no 1479 0.453024170961564 2207 689013 SGTC_100 0086-0128 49.5915 µM 0.117808360232179 0.449819312413676 no 1480 0.453109752586939 2005 93297 SGTC_1559 coumarin 343 70.1 µM 0.117590418927593 0.449912180182802 no 1481 0.453196098430894 2163 108770 A hepatotoxic, DNA x-linker. SGTC_1288 0973-0013 65.5 µM 0.117499518066478 0.449950915093278 no 1482 0.453232112963158 2128 4315430 SGTC_3080 9117754 49.47 µM 0.1174583675215 0.449968450426943 no 1483 0.453248416759522 2206 9550191 SGTC_2348 9022543 33.42 µM 0.117133714604674 0.450106797028951 no 1484 0.453377046615352 2118 3162678 YDL140C RPO21 SGTC_2982 9019404 25.97 µM 0.116113379379076 0.450541638961918 no 1485 0.453781342663878 1938 22333232 SGTC_2868 9035608 32.47 µM 0.115946436301876 0.450612791686737 no 1486 0.453847496500991 2214 6462614 SGTC_2166 5933061 31.504 µM 0.115627218670694 0.450748849689791 no 1487 0.453973995104351 2155 2877375 SGTC_2886 9058944 51.95 µM 0.115517710496863 0.450795525962821 no 1488 0.454017391750583 2208 4949929 SGTC_1700 st030840 7.9285 µM 0.114996564463308 0.451017666225352 no 1489 0.454223922570234 2215 5499307 SGTC_655 k060-0012 42 µM 0.114437646172346 0.451255924089291 no 1490 0.454445436336841 2109 5994525 SGTC_1697 st025554 27.742 µM 0.114400885736202 0.451271595087494 no 1491 0.454460005945269 2188 1269519 SGTC_1923 st058458 19.1 µM 0.113919637770056 0.45147675840932 no 1492 0.454650749109641 2238 3534982 SGTC_2865 9030313 51.95 µM 0.113910674179876 0.451480579847166 no 1493 0.454654301937875 2072 42562754 SGTC_1729 st035615 45.989 µM 0.113747646084689 0.451550084225413 no 1494 0.454718920743419 2051 17385451 SGTC_2600 tangeritin 87.95 µM 0.113465754169066 0.45167026776442 no 1495 0.454830655960812 2153 68077 A bioactive flavone. SGTC_447 ml7 120 µM 0.112911445798238 0.451906607925119 no 1496 0.455050380964779 2223 4216 Selective myosin light chain kinase inhibitor. SGTC_3336 9143619 71.43 µM 0.112138423077381 0.452236229647071 no 1497 0.455356826166756 2215 45595730 SGTC_3212 9128307 49.47 µM 0.111037047869656 0.452705919740481 no 1498 0.455793484207068 1904 27243542 SGTC_1341 1486-1360 280 µM 0.110728187425632 0.452837647609299 no 1499 0.455915946543233 2117 3976547 SGTC_996 3970-0799 1.8 µM 0.110706151427801 0.452847046081683 no 1500 0.455924683917367 2182 6615648 YGL040C HEM2 SGTC_2619 obliquin 87.91 µM 0.1096372663038 0.453302962992422 no 1501 0.456348527280805 2170 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2240 6690706 185.951 µM 0.109425458901016 0.453393313588394 no 1502 0.456432520854272 2050 805876 SGTC_1817 st052116 64.4 µM 0.108929891894512 0.453604716818389 no 1503 0.45662904870377 2188 4361398 SGTC_2220 6782180 200 µM 0.107374343920658 0.454268380961921 no 1504 0.45724600370158 2211 833803 SGTC_410 α-linolenic acid 100 µM 0.10577759786166 0.454949754796058 no 1505 0.457879405686138 2188 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2366 9070441 60.58 µM 0.105368135799525 0.455124504538573 no 1506 0.458041849616682 2191 6837235 SGTC_1695 st026914 34.495 µM 0.10513436424694 0.455224277186229 no 1507 0.458134595834203 2114 3289191 SGTC_1564 D-Arginine 115 µM 0.104587517621392 0.455457679887516 no 1508 0.458351559937456 2080 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2793 7325131 81.82 µM 0.104301769278518 0.455579647875106 no 1509 0.458464936946101 2150 4176441 SGTC_3318 9139014 38.6185 µM 0.102544273445635 0.456329903893679 no 1510 0.459162336455962 2104 16643984 SGTC_55 0767-0285 6.563 µM 0.102014630760298 0.456556033301727 no 1511 0.459372531002226 2223 3116166 SGTC_1415 3966-0071 78.1 µM 0.101164724163141 0.456918927831455 no 1512 0.459709849527725 2224 2893185 SGTC_409 arachidonic acid 100 µM 0.100499088335869 0.457203167226588 no 1513 0.459974053288603 2234 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1524 corynanthine 62.1 µM 0.100061311914616 0.457390118184541 no 1514 0.460147824876899 2127 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_478 N-arachidonylglycine 10 µM 0.098576420245333 0.458024306200483 no 1515 0.460737296366935 2236 5283389 SGTC_2088 5278280 127.392 µM 0.0975280755270928 0.458472112184786 no 1516 0.461153519727331 2164 791502 SGTC_79 0052-0007 94.094 µM 0.0974189944836928 0.458518709766009 no 1517 0.461196830528117 2230 2801472 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0972707586407801 0.458582034530493 no 1518 0.461255688541579 2060 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2094 5332512 191.667 µM 0.0968543811635218 0.45875991214707 no 1519 0.461421018485023 2212 755774 SGTC_1938 st074717 56.4 µM 0.0963956136116586 0.458955908481748 no 1520 0.461603187866526 2240 17250979 SGTC_694 1315-0438 43.2 µM 0.0961301664917678 0.459069318321242 no 1521 0.461708596425864 2176 6793154 SGTC_734 2023-0417 80 µM 0.0959424212531739 0.459149532758708 no 1522 0.461783151336577 2192 3935732 SGTC_406 estrone 100 µM 0.0932595826199095 0.460295959748486 no 1523 0.462848670246951 2255 5870 A steroid. SGTC_626 0214-0009 33 µM 0.0928563957098671 0.460468277803694 no 1524 0.463008823600592 2194 3437874 SGTC_1408 3909-7976 48.8 µM 0.088909685843269 0.462155449214185 no 1525 0.464576842925233 2176 24152374 SGTC_1814 st052110 31.539 µM 0.088481156815897 0.462338681802795 no 1526 0.464747130137924 2232 674163 SGTC_1816 st051957 91.6 µM 0.0879797552338067 0.462553083747581 no 1527 0.464946383360443 2212 674121 SGTC_2419 paclitaxel 166.5 µM 0.0876559543283731 0.462691548497856 no 1528 0.465075064082313 2090 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_695 3505-6186 243 µM 0.0870490199906455 0.462951099812651 no 1529 0.465316273819352 2199 1819379 SGTC_2255 7941087 197.44 µM 0.0865903243294723 0.463147268343361 no 1530 0.465498578539391 2265 935561 SGTC_312 4092-0653 6.84 µM 0.0862497367771076 0.463292931853982 no 1531 0.465633946874664 2218 1148278 SGTC_1622 st003707 19.4 µM 0.0862380262616318 0.463297940330156 no 1532 0.465638601352167 2176 10140899 SGTC_2999 9069765 71.4286 µM 0.0848301451777787 0.463900119853038 no 1533 0.466198213762984 2219 2097066 SGTC_1394 3474-0001 65.7 µM 0.0845976551757903 0.463999568573921 no 1534 0.466290631642762 2190 5017666 YIL048W NEO1 SGTC_2023 5144124 124 µM 0.0845469548132421 0.464021256197764 no 1535 0.466310785955371 2204 2830192 SGTC_1556 plumbagin 1.48 µM 0.0845420198775251 0.464023367175155 no 1536 0.466312747686335 2257 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2864 9034755 47.6 µM 0.0843878591112976 0.464089311784371 no 1537 0.466374029939753 2272 4930451 SGTC_651 3253-0966 34.4 µM 0.0841590601972797 0.46418718581306 no 1538 0.466464983947529 2196 781462 SGTC_499 genistein 192 µM 0.0838607262492726 0.464314808315589 no 1539 0.466583582718298 2267 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2715 st079500 56.4 µM 0.0824642819232449 0.464912233518124 no 1540 0.467138760229639 2228 28246688 SGTC_879 0831-1030 162 µM 0.0824259095833427 0.464928651051215 no 1541 0.467154016639825 2252 1549252 SGTC_2301 7769476 200 µM 0.0812317144613662 0.465439614878141 no 1542 0.467628839177758 2204 977820 SGTC_2168 5727979 200 µM 0.0807115344718636 0.465662203707699 no 1543 0.467835681782185 2246 695210 SGTC_1991 st073000 8.92 µM 0.0795932278261446 0.466140771601241 no 1544 0.468280390770604 2233 4301969 YIL048W NEO1 SGTC_3178 9107506 49.47 µM 0.0795156525610923 0.466173970966677 no 1545 0.468311241044824 2226 8897194 SGTC_2809 7964133 12.99 µM 0.0791763593345391 0.466319178774355 no 1546 0.468446174033671 2194 1253665 SGTC_1960 st011366 51.8 µM 0.077710363323763 0.466946634477557 no 1547 0.469029225148839 2266 3972846 SGTC_368 fentichlor 4.58 µM 0.0776321809902489 0.466980099339321 no 1548 0.469060321446355 2173 7329 A pesticide. SGTC_261 5-fluorouridine 15.376 µM 0.0769430060193228 0.467275101182465 no 1549 0.469334442537964 2255 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_605 1315-0399 119 µM 0.0757129229970868 0.467801683677096 no 1550 0.469823747220871 2209 24020461 SGTC_2423 st077119 87.2 µM 0.0723329088492539 0.469248911029214 no 1551 0.471168487902332 2271 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_994 3910-0338 138 µM 0.0716148452300946 0.469556418735689 no 1552 0.471454212812999 2242 3479481 SGTC_2033 5192550 145 µM 0.0712253705068712 0.469723217245531 no 1553 0.471609194972819 2234 182073 SGTC_1468 k284-1086 134 µM 0.0702033501479326 0.470160938292207 no 1554 0.472015903937175 2206 15996457 SGTC_2359 9039622 200 µM 0.0695692265830363 0.47043254520218 no 1555 0.472268265601931 2236 6463596 SGTC_3341 9147222 25.867 µM 0.0692630806616321 0.470563678122469 no 1556 0.472390106248751 2204 1939759 SGTC_2543 pimpinellin 60.67 µM 0.0686270366478338 0.470836128030776 no 1557 0.472643248731846 2221 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1483 3453-0561 55.9 µM 0.0684371530329077 0.470917467464855 no 1558 0.472718823651138 2271 4546991 SGTC_858 0438-0351 2.77 µM 0.0678791510564005 0.47115650281218 no 1559 0.472940917756824 2183 2799119 SGTC_1472 k841-0093 193 µM 0.0678463110877319 0.471170571031988 no 1560 0.472953988875592 2264 X1472 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0675573125046391 0.471294375853906 no 1561 0.473069018705011 2293 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_197 4544-0043 41.561 µM 0.0665054325227874 0.471745016671714 no 1562 0.473487716379776 2288 896523 SGTC_2079 5212404 121 µM 0.0662378634193783 0.471859652995834 no 1563 0.473594226150995 2290 758462 SGTC_2710 st078562 53.7235 µM 0.0661568345524272 0.471894369166382 no 1564 0.473626481242126 2283 17250908 SGTC_3229 9132204 49.47 µM 0.0642938464512028 0.472692609894881 no 1565 0.474368126569892 2211 17682924 SGTC_3185 9108267 49.47 µM 0.0628697048896859 0.473302890723141 no 1566 0.474935129550058 2205 4910486 SGTC_359 0081-0058 15.9 µM 0.0628407387976258 0.473315304084361 no 1567 0.474946662544207 2266 3494159 SGTC_1702 st027038 51 µM 0.0626841345707206 0.47338241696322 no 1568 0.475009015662212 2202 5521182 SGTC_1282 0886-0010 32.4 µM 0.0618826341238502 0.473725912470873 no 1569 0.475328148475821 2289 2836211 YNL267W PIK1 SGTC_3017 9080681 49.47 µM 0.0608499602135022 0.474168509733352 no 1570 0.475739350755519 2214 16451914 SGTC_2954 9074818 52.69 µM 0.0608123527520278 0.474184628649635 no 1571 0.475754326228469 2269 16648742 SGTC_1527 coumarin 137 µM 0.0603939708253997 0.474363953973755 no 1572 0.47592093023918 2250 323 A hepatotoxic, DNA x-linker. SGTC_2151 5563267 85.4165 µM 0.0599816049390522 0.474540705807729 no 1573 0.476085142719958 2205 5310824 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0597489510728622 0.474640430134224 no 1574 0.476177792014177 2221 688803 SGTC_481 bay k-8644 50 µM 0.0574154423777057 0.475640747874987 no 1575 0.477107131027801 2223 2303 A calcium channel antagonist. SGTC_2983 9022671 12.99 µM 0.0569625668742151 0.475834902444654 no 1576 0.477287507003819 2323 6405161 SGTC_2973 9094665 17.96 µM 0.0566046942167692 0.475988331919856 no 1577 0.477430047549281 2283 25237061 YIL048W NEO1 SGTC_2928 9011484 9.79 µM 0.0565375399850911 0.476017123112839 no 1578 0.477456795376918 2243 2994751 SGTC_1349 flufenamic acid 69 µM 0.0556007422646259 0.476418771610015 no 1579 0.477829936589874 2290 3371 A non-steroidal anti-inflammatory. SGTC_2430 5571206 200 µM 0.0542423269275002 0.477001229526078 no 1580 0.47837104914575 2305 1731771 SGTC_1773 st048542 73.5835 µM 0.0537654776448457 0.477205703479339 no 1581 0.478561007283129 2263 3237138 SGTC_1447 4239-0816 81.9 µM 0.0514826539986868 0.478184665148974 no 1582 0.47947046181214 2208 1341554 SGTC_3056 9094900 49.47 µM 0.0510349098258833 0.478376690520005 no 1583 0.479648851382006 2288 25236784 SGTC_2603 homopterocarpin 100 µM 0.0508128688572142 0.478471919753321 no 1584 0.479737318129944 2271 101795 A weak amylase inhibitor. SGTC_2747 doxorubicin 7.63 µM 0.0501179727727594 0.478769955650527 no 1585 0.480014188767036 2324 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3166 9102297 49.47 µM 0.0495465845551551 0.479015028819674 no 1586 0.480241856827866 2258 25237072 SGTC_508 roscovitine 141 µM 0.0495337774680914 0.47902052197732 no 1587 0.480246959850546 2326 160355 A CDKinase inhibitor. SGTC_1197 1601-0112 267 µM 0.049424086950481 0.479067570099315 no 1588 0.480290666502458 2319 7350313 SGTC_3274 9138298 49.47 µM 0.0481607364889884 0.479609463382059 no 1589 0.480794070799124 2323 17015756 SGTC_2375 9072683 200 µM 0.0470652976713653 0.480079364287181 no 1590 0.48123059255945 2341 16798029 SGTC_2134 5324836 1.464 µM 0.0466148881749802 0.48027258061804 no 1591 0.48141008294106 2287 699272 SGTC_2653 dihydrofissinolide 100 µM 0.0454576627775939 0.480769027452692 no 1592 0.481871260100016 2286 6857746 SGTC_2390 9097792 176.6 µM 0.0454090016466504 0.480789903616453 no 1593 0.481890653056876 2244 4497149 SGTC_2054 5233173 129 µM 0.0446624752855602 0.481110178257687 no 1594 0.482188172109099 2294 6889 SGTC_1607 st000305 50.6 µM 0.0446373552023017 0.481120955485708 no 1595 0.482198183587906 2311 5457690 SGTC_254 nsc-64875 3.808 µM 0.0438391963103146 0.481463395425261 no 1596 0.482516291483062 2314 56993 SGTC_700 3453-2283 142 µM 0.0435712625175619 0.481578352096452 no 1597 0.482623079561832 2310 565664 SGTC_3115 9123671 49.47 µM 0.0433817425053008 0.481659666355044 no 1598 0.48269861568442 2344 3286988 SGTC_2029 5175081 200 µM 0.0424045728419059 0.482078936629688 no 1599 0.483088091514657 2318 1380876 SGTC_2015 5119600 184 µM 0.0411596859067631 0.482613103932098 no 1600 0.483584296202548 2304 2828786 SGTC_2640 pentamidine 10.38 µM 0.0407709453185604 0.482779914686393 no 1601 0.483739251184352 2334 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_865 0488-0499 301 µM 0.0387659785259088 0.48364030434374 no 1602 0.484538484818819 2343 9634651 SGTC_2839 9003951 25.97 µM 0.0381300822444241 0.483913202065944 no 1603 0.484791983290735 2365 2990634 SGTC_1465 k213-0056 144 µM 0.036522897871148 0.484602965702461 no 1604 0.485432710513213 2268 24048857 YMR208W ERG12 SGTC_1940 st075990 51.1 µM 0.036403474204049 0.484654221240304 no 1605 0.485480322001489 2274 1084979 SGTC_471 1-acyl-paf 4 µM 0.0346605281438364 0.485402306052747 no 1606 0.486175217989859 2330 16759367 SGTC_1058 3448-5425 97.3 µM 0.0342781045129387 0.485566451952675 no 1607 0.486327692337449 2341 7279705 SGTC_1221 2958-7315 257 µM 0.0336487263899255 0.485836602281574 no 1608 0.486578633103402 2317 4562705 SGTC_1827 berberine 7.24 µM 0.0333942727304649 0.485945824231058 no 1609 0.486680088408071 2340 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0326815595207612 0.486251755565486 no 1610 0.486964264703116 2340 688798 SGTC_2334 9017922 200 µM 0.0324989376945084 0.486330147086114 no 1611 0.487037081590268 2338 3163164 SGTC_2006 4011487 200 µM 0.0316932698027996 0.486675991153568 no 1612 0.487358331055772 2339 45595294 SGTC_2172 5754775 163.918 µM 0.0315155710821703 0.486752272141079 no 1613 0.487429187192723 2323 2263357 SGTC_813 k007-0158 173 µM 0.0313496216876456 0.486823509916079 no 1614 0.487495358725448 2335 6523916 SGTC_2616 abietic acid 100 µM 0.0311900734279774 0.486892000246219 no 1615 0.487558978160673 2365 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1265 0819-1001 68.8 µM 0.0306099768404459 0.487141025364742 no 1616 0.487790292755626 2357 3106768 SGTC_3046 9092212 49.47 µM 0.0303447451398181 0.487254886279373 no 1617 0.487896055763374 2355 25236637 SGTC_2256 7954252 200 µM 0.0295207173508935 0.487608638505705 no 1618 0.488224648042182 2246 2972920 SGTC_1616 st002734 56.1 µM 0.0289624405739567 0.487848310316189 no 1619 0.488447273049454 2271 4026101 SGTC_1853 st056710 91.2 µM 0.0273864917801983 0.488524898664206 no 1620 0.489075736103357 2365 269167 SGTC_1565 sinapyl alcohol 95.1 µM 0.0273850040121953 0.488525537410574 no 1621 0.489076329414389 2328 5280507 A phenol propionate derived from cinnamic acid. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0269006565051293 0.488733484835065 no 1622 0.489269484946321 2346 140250 A respiratory chain inhibitor. SGTC_1441 4106-0040 13 µM 0.0264410056574601 0.488930831948213 no 1623 0.489452793893597 2358 2904180 SGTC_806 3966-4455 5.86 µM 0.0261939753540296 0.489036893393635 no 1624 0.489551310603173 2274 714982 SGTC_1144 3486-0183 12.5 µM 0.0253974105348876 0.489378900467268 no 1625 0.489868988268446 2295 6744069 SGTC_918 glabranin 770.725 nM 0.0252756101253097 0.489431196468757 no 1626 0.48991756400774 2343 124049 Also referred to as licorice root. SGTC_594 1487-1584 10.8 µM 0.0251757230627594 0.489474083931216 no 1627 0.48995740050356 2356 5013332 SGTC_1841 st054148 70 µM 0.0245872790294585 0.489726740440078 no 1628 0.490192083048762 2281 675442 SGTC_2746 daunorubicin 9.88 µM 0.024380820195076 0.489815387351734 no 1629 0.490274423522846 2367 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_926 2268-1401 59.4 µM 0.02429311973203 0.489853043316939 no 1630 0.490309400585772 2365 2931578 SGTC_2260 7964312 200 µM 0.0234456774652535 0.490216914380476 no 1631 0.490647384829406 2366 231951 SGTC_1961 st076550 68.7 µM 0.0224680569527955 0.490636690906207 no 1632 0.491037296211842 2351 1579337 SGTC_746 1095-0025 46.6 µM 0.0222422204960922 0.490733663402299 no 1633 0.491127369412732 2362 6749286 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.0212103461631764 0.491176749453637 no 1634 0.491538930547588 2360 688662 SGTC_790 1575-0012 79.1 µM 0.0210480099555402 0.491246457502501 no 1635 0.491603678869579 2365 378741 YLR208W SEC13 SGTC_2254 7938975 95.19 µM 0.0203978039845674 0.491525662134784 no 1636 0.491863017826709 2366 2969277 SGTC_26 0302-0163 425.158 µM 0.0203961142500308 0.491526387728345 no 1637 0.491863691793047 2358 3100915 SGTC_1184 1269-1718 139 µM 0.0199614484449406 0.491713039693187 no 1638 0.492037063058649 2368 5403821 SGTC_196 k015-0023 18.111 µM 0.0199432109049674 0.491720871204188 no 1639 0.492044337336362 2363 5211998 SGTC_1121 fusaric acid 630.51 nM 0.0194290602820183 0.491941657560824 no 1640 0.492249414014131 2355 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2228 7354201 200 µM 0.0191378102191206 0.492066727147052 no 1641 0.492365584376947 2326 753451 SGTC_1304 1165-0502 251 µM 0.0189724099098343 0.492137754254814 no 1642 0.492431557575008 2365 767425 SGTC_1760 st045453 10.4495 µM 0.018395769130808 0.492385380434961 no 1643 0.492661563808639 2357 3323419 YIL048W NEO1 SGTC_2132 5317594 122.667 µM 0.0179818650824622 0.492563124584463 no 1644 0.492826660320423 2369 794577 SGTC_1107 amlodipine 47 µM 0.0177421839033244 0.492666052323087 no 1645 0.49292226402388 2366 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_424 splitomicin 100 mM 0.0148643231710263 0.493901945632898 no 1646 0.494070211380922 2301 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1181 1222-0449 220 µM 0.0147915710741738 0.493933189728776 no 1647 0.494099232077801 2372 658318 SGTC_2902 5787006 60.46 µM 0.0147777002126381 0.493939146709458 no 1648 0.494104765146176 2356 591003 SGTC_307 1501-1223 22.3 µM 0.0143891215598676 0.494106026255711 no 1649 0.494259769115374 2357 2830329 SGTC_2050 5263056 171 µM 0.0136546395456769 0.494421460750096 no 1650 0.494552756234471 2377 763468 YGL055W OLE1 SGTC_2707 st078556 66.6 µM 0.0134835864068311 0.494494922635389 no 1651 0.494620990281725 2389 17250899 SGTC_1233 0325-0408 14.2 µM 0.0128684243666915 0.494759116700577 no 1652 0.494866383123069 2376 12874 SGTC_3064 1327-0027 10 µM 0.0127659031663104 0.494803146777735 no 1653 0.494907279805135 2359 16000455 YPR107C YTH1 SGTC_869 0564-0080 44.1 µM 0.012078665270964 0.495098298437381 no 1654 0.495181426899822 2354 6843321 SGTC_438 sphingosine 6.67 µM 0.0119151220137613 0.495168536618218 no 1655 0.495246666524732 2383 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2312 7706453 155.7 µM 0.0119022030712919 0.49517408502224 no 1656 0.49525182007166 2386 976098 SGTC_519 k048-0011 62.8 µM 0.0114008731173683 0.495389396013757 no 1657 0.495451808209128 2337 6836379 SGTC_329 k048-0121 21.3 µM 0.0106749292178167 0.495701176478294 no 1658 0.4957414002757 2357 6832902 SGTC_2295 7971645 200 µM 0.0103729244866454 0.495830883119288 no 1659 0.495861876059674 2371 2978226 YKL099C UTP11 SGTC_146 3448-8650 53.125 µM 0.0102957380018776 0.495864033663493 no 1660 0.49589266736764 2366 2891488 YIL048W NEO1 SGTC_1741 st038134 10.228 µM 0.0100318818477639 0.495977356503212 no 1661 0.495997925306283 2383 1272587 SGTC_356 1634-0012 32.5 µM 0.00891446323528272 0.496457276978523 no 1662 0.496443690810349 2394 735457 SGTC_876 0720-0963 56.8 µM 0.00727432174811505 0.497161710957388 no 1663 0.497097991087122 2390 765861 SGTC_2099 5377090 177.372 µM 0.00593249475035869 0.497738026778844 no 1664 0.497633290898352 2385 2243829 SGTC_3076 9116187 49.47 µM 0.0055715289295586 0.497893062757546 no 1665 0.497777293043046 2391 27241210 SGTC_1215 3852-0577 11.2 µM 0.00519542349736382 0.498054601586092 no 1666 0.49792733522669 2395 2884876 SGTC_1385 3091-4834 14.1 µM 0.0049952659572529 0.498140570203747 no 1667 0.498007185495483 2390 4072814 SGTC_22 0964-0034 14.468 µM 0.00498623844547668 0.498144447565155 no 1668 0.498010786906766 2393 138402 SGTC_2924 9010168 62.78 µM 0.00448016244476094 0.498361810005338 no 1669 0.498212679756859 2393 2993929 SGTC_614 0462-0418 107 µM 0.00407797053191872 0.498534554005418 no 1670 0.498373129645688 2373 5188303 SGTC_2774 tamoxifen 10.92 µM 0.00406087603445434 0.498541896207778 no 1671 0.498379949307021 2399 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2170 morpholine 200 µM 0.00380481015430459 0.498651878294135 no 1672 0.498482104022872 2395 121171 Reacts with secondary amines. SGTC_472 calcifediol 10 µM 0.00376672857784038 0.498668234606509 no 1673 0.498497296264959 2392 5283731 A vitamin D metabolite. SGTC_209 4077-0173 175.592 µM 0.00373453561119067 0.498682061720149 no 1674 0.498510139310153 2365 15993494 SGTC_76 0433-0009 400.328 µM 0.00277516381034356 0.499094119549189 no 1675 0.498892871242113 2365 2841569 SGTC_47 0149-0135 24.25 µM 0.00272939566340557 0.499113777360442 no 1676 0.498911130021864 2404 5239155 SGTC_161 4065-0411 162.148 µM 0.00232643700528732 0.499286851644184 no 1677 0.499071886753106 2392 1906281 YLR208W SEC13 SGTC_1496 4469-0713 57.4 µM 0.00153837828377519 0.499625330146281 no 1678 0.499386276101425 2402 746691 SGTC_225 nsc-122657 1.016 µM -0.00020626194722666 0.499625330146281 no 1679 0.499917713388997 2406 275685 SGTC_794 k038-0031 316 µM -0.000874991085451462 0.499338104775769 no 1680 0.499650929105581 2408 6624242 SGTC_1530 rhein 70.4 µM -0.000892943528404035 0.49933039403899 no 1681 0.499643767119849 2406 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2041 5107442 45.335 µM -0.00254909285648124 0.498619064361592 no 1682 0.498983060184205 2410 793005 SGTC_2628 lathosterol 100 µM -0.00274344271181418 0.498535589753897 no 1683 0.498905526081321 2418 6710616 SGTC_697 0508-1955 564 µM -0.0028491036270312 0.498490207686346 no 1684 0.498863373639673 2414 6243113 SGTC_175 3793-3120 23.7 µM -0.00314271585524497 0.498364099381157 no 1685 0.498746239833883 2416 5322297 SGTC_1932 st074806 40.9 µM -0.00345427853422691 0.49823028142311 no 1686 0.498621944984916 2448 17251235 SGTC_1805 st050013 60.3 µM -0.00392836740868035 0.498026657918745 no 1687 0.498432812178553 2412 4037144 SGTC_1730 st033808 45.1 µM -0.00421064399195633 0.497905418978043 no 1688 0.498320201047564 2423 1045166 SGTC_3244 9134489 49.47 µM -0.00565131881689885 0.497286646532432 no 1689 0.497745461984599 2428 16584271 SGTC_1315 1237-0019 3.69 µM -0.00589181817110921 0.497183352219922 no 1690 0.497649518222032 2414 825140 SGTC_2459 5811157 9.22 µM -0.00610371732613182 0.497092341830178 no 1691 0.497564984210564 2419 2870684 YBR192W RIM2 SGTC_2329 6138490 200 µM -0.00611111925680126 0.49708916271405 no 1692 0.497562031322536 2441 720019 SGTC_315 k915-0449 187 µM -0.00727231125007528 0.496590435226176 no 1693 0.49709879313858 2427 20970215 YNL149C PGA2 SGTC_467 ro 31-8220 72.8 µM -0.00754536489545684 0.496473160482355 no 1694 0.496989863484621 2423 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3093 9117344 49.47 µM -0.00766694015824283 0.496420944804492 no 1695 0.496941363375047 2463 24824913 SGTC_1191 1487-1166 10.6 µM -0.00786863687910141 0.496334317687544 no 1696 0.496860900452959 2440 3955771 SGTC_2372 9071633 200 µM -0.00806344526592106 0.496250649218632 no 1697 0.496783185616848 2426 21321366 SGTC_3202 9113761 49.47 µM -0.00832000293596805 0.49614046023418 no 1698 0.49668083734925 2431 4798415 SGTC_3110 9122132 49.47 µM -0.00866493792616215 0.495992314529501 no 1699 0.496543233160592 2477 918317 SGTC_3044 9093193 49.47 µM -0.00936417375043066 0.495692002312616 no 1700 0.496264289766012 2432 25236277 SGTC_137 0438-0332 85.389 µM -0.00945751122921169 0.495651915323857 no 1701 0.496227055148253 2419 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1245 0418-0076 17.2 µM -0.00997095411736421 0.495431400421739 no 1702 0.496022230738338 2440 6790114 SGTC_3251 9135047 49.47 µM -0.00998875197368101 0.495423756572772 no 1703 0.49601513077453 2431 17682963 SGTC_1980 st071811 45.7 µM -0.0101143995174129 0.495369793332671 no 1704 0.495965007189102 2458 4974850 SGTC_67 0335-0847 266 µM -0.0108286974654103 0.495063017532989 no 1705 0.495680059166077 2430 4552207 YOR254C SEC63 SGTC_2951 9072950 58.06 µM -0.0109297887746706 0.495019601194103 no 1706 0.495639731955242 2425 16488155 SGTC_2331 7980721 200 µM -0.0139759619731641 0.493711371487842 no 1707 0.494424579365721 2452 2981221 SGTC_888 0916-0002 6.97 µM -0.0140704250301845 0.493670803766603 no 1708 0.494386897763578 2493 2802138 YIL048W NEO1 SGTC_1670 st016595 4.04 µM -0.014277839640363 0.493581728559824 no 1709 0.494304159617867 2434 597879 SGTC_2391 6285546 200 µM -0.01448436161133 0.493493037019225 no 1710 0.494221777791345 2430 846083 SGTC_1718 roemerine 11.9335 µM -0.0147671838052569 0.493371578619334 no 1711 0.494108960127969 2438 235224 An aporphine alkaloid with mutagenic activity. SGTC_977 1348-1378 135 µM -0.0151339469396548 0.493214072578051 no 1712 0.493962659159051 2433 X977 SGTC_1331 1472-0049 76.2 µM -0.0162420069088842 0.492738223919666 no 1713 0.493520661604649 2439 24051409 SGTC_3302 9125395 16.351 µM -0.0164274952543628 0.49265856822924 no 1714 0.493446672332941 2458 17599668 SGTC_49 0717-0965 32.132 µM -0.0167520854419878 0.492519177668459 no 1715 0.493317197402207 2584 5889349 YGL099W LSG1 SGTC_720 r052-1644 49.9 µM -0.0186304067296742 0.491712578232563 no 1716 0.492567972989866 2466 1422863 YOR257W CDC31 SGTC_2956 9076196 2.52 µM -0.0187381483045171 0.49166631222744 no 1717 0.492524997822343 2432 16423868 SGTC_641 4092-0595 30 µM -0.0206459636125113 0.490847084084614 no 1718 0.491764037303992 2455 786260 SGTC_1353 1498-1206 8.11 µM -0.0214412307406186 0.49050560247653 no 1719 0.49144684187081 2441 6756808 SGTC_2528 xanthyletin 44.79 µM -0.0218129167677452 0.490346005716914 no 1720 0.491298595274176 2466 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2937 9044753 11.33 µM -0.0230502525873157 0.489814722374562 no 1721 0.490805093906807 2453 6465530 YGL099W LSG1 SGTC_2341 7987486 176.74 µM -0.0234779510704251 0.489631082707029 no 1722 0.490634513066925 2459 1258686 SGTC_2724 maprotiline 69.64 µM -0.0234859727016425 0.489627638503183 no 1723 0.490631313781243 2433 4011 A tricyclic antidepressant. SGTC_689 0833-0039 98 µM -0.0235447934644556 0.489602382978173 no 1724 0.490607854179158 2458 5374726 SGTC_62 0180-0423 3.232 µM -0.0235864336184368 0.489584504215336 no 1725 0.490591246773177 2468 30102 YGL099W LSG1 SGTC_1471 k673-0312 37 µM -0.0242263572054025 0.489309747029124 no 1726 0.490336027143902 2452 24099884 SGTC_401 neomycin 50 µM -0.024227749555858 0.489309149215898 no 1727 0.490335471839429 2477 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2115 tiliquinol 12.7705 µM -0.0256671120546179 0.488691164206488 no 1728 0.489761427994254 2500 71208 A bioactive hydroxyquinoline. SGTC_3125 9127534 49.47 µM -0.0264011630036707 0.488376012484273 no 1729 0.489468683265812 2456 1639235 SGTC_290 2043-6722 48.1 µM -0.0268821324739698 0.48816952071822 no 1730 0.489276872294002 2475 773758 YLR208W SEC13 SGTC_223 busulfan 5 mM -0.0270999968586314 0.488075987336191 no 1731 0.48918998863364 2497 2478 A DNA alkylator. SGTC_474 dl-dihydrosphingosine 5 µM -0.0278683330057377 0.487746131079672 no 1732 0.488883582614775 2553 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3222 9128301 49.47 µM -0.0294715350265023 0.487057883784183 no 1733 0.488244260417379 2473 4911358 SGTC_907 3448-6986 75.5 µM -0.0298894583482612 0.486878477463945 no 1734 0.488077606557094 2474 590582 SGTC_2139 5578692 56.4705 µM -0.0303873492057575 0.486664746111642 no 1735 0.487879067034587 2458 650991 YMR113W FOL3 SGTC_1445 4239-0156 97.7 µM -0.0315171358921652 0.486179772926769 no 1736 0.487428563233815 2494 4008346 SGTC_2965 9082772 38.63 µM -0.0319027406153818 0.486014252560858 no 1737 0.487274806529324 2477 16459634 SGTC_1141 3253-0389 52.6 µM -0.0319438296104736 0.485996615300445 no 1738 0.487258422742378 2438 5402031 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.032681000092705 0.485680192980056 no 1739 0.486964487763467 2455 66535 A nucleotide analog. SGTC_1644 st010134 20.9 µM -0.0334602026387751 0.485345738664471 no 1740 0.486653800870798 2479 3818134 SGTC_2165 5727197 32.143 µM -0.0338364978316305 0.48518422650442 no 1741 0.486503765769119 2650 1361712 SGTC_2198 6589944 200 µM -0.0339922579588155 0.485117372375024 no 1742 0.486441662194419 2476 5290268 SGTC_1859 st055998 20 µM -0.0344330447392763 0.484928183633859 no 1743 0.486265916598172 2468 676301 SGTC_883 0850-0245 24.6 µM -0.0347018807783768 0.484812799005517 no 1744 0.486158730593922 2605 6823229 YPR165W RHO1 SGTC_3250 9135583 49.47 µM -0.0348115022432928 0.484765749755514 no 1745 0.48611502436389 2527 7699353 SGTC_2641 levomentholum 100 µM -0.0349014399948307 0.484727148862883 no 1746 0.486079166182199 2458 16666 SGTC_1955 wogonin 32.4 µM -0.0358214804107294 0.484332279794157 no 1747 0.485712352583146 2628 5281703 A flavanone. SGTC_1931 st074438 57.1 µM -0.0371385159632098 0.48376705254715 no 1748 0.485187280950767 2456 2787313 SGTC_1793 st048256 72.231 µM -0.0373176005218276 0.483690197987602 no 1749 0.485115886039923 2468 672022 SGTC_3058 9093861 49.47 µM -0.0374513368926219 0.483632805104591 no 1750 0.485062570217303 2496 17217477 SGTC_2104 5389443 200 µM -0.0377193756661658 0.483517777448449 no 1751 0.484955713720627 2517 2244536 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0378869055041239 0.483445883454257 no 1752 0.484888926724063 2479 5106787 A p450 inhibitor. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0385322785274498 0.483168932203425 no 1753 0.484631648021425 2583 6710655 SGTC_1442 4112-3290 3 µM -0.0388307518474578 0.483040850010451 no 1754 0.484512663444159 2458 704353 SGTC_1419 3993-2473 62.6 µM -0.0392021541283448 0.482881474664158 no 1755 0.48436460810613 2491 704026 SGTC_3192 9110362 49.47 µM -0.0407580282873069 0.482213851323602 no 1756 0.483744400054428 2475 16649480 SGTC_982 1491-0518 27.5 µM -0.0416404765462231 0.481835216103343 no 1757 0.483392652795895 2509 3091256 SGTC_968 1309-0633 340 µM -0.0424147348964038 0.481503015795934 no 1758 0.483084041085609 2477 3761976 SGTC_40 0327-0103 19.753 µM -0.0425597279340265 0.481440807062188 no 1759 0.483026249417878 2505 409036 SGTC_1885 st057546 99.9 µM -0.0430716294635172 0.481221181203266 no 1760 0.482822217356308 2616 702008 SGTC_220 paclitaxel 373.376 µM -0.0431156144807804 0.481202310168498 no 1761 0.482804686159023 2489 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1132 3456-3614 2.5 µM -0.0433170249033425 0.48111589893966 no 1762 0.482724410024771 2527 3125502 SGTC_960 1222-0186 7.7 µM -0.0436550638937176 0.480970871874529 no 1763 0.482589679430177 2527 3126296 SGTC_2279 7948423 32.93 µM -0.0438286865230059 0.480896384461663 no 1764 0.48252048025546 2470 1247112 SGTC_971 1315-0384 26.7 µM -0.0445714260415211 0.480577742632017 no 1765 0.482224459366133 2505 6769120 SGTC_2344 7990960 76.95 µM -0.0448683535256695 0.480450361573082 no 1766 0.482106120828868 2505 140813 SGTC_2038 4100038 30.985 µM -0.0449109166474541 0.480432102276349 no 1767 0.482089157699642 2545 3596803 SGTC_3158 9100007 49.47 µM -0.0457162229076244 0.480086639016159 no 1768 0.481768216658916 2506 19297233 SGTC_488 nitrendipine 139 µM -0.0466330344505297 0.479693360027935 no 1769 0.481402851488628 2478 4507 Dihydropyridine L-type calcium channel blocker. SGTC_349 k015-0014 24 µM -0.0471269684795205 0.479481488365764 no 1770 0.481206016736883 2493 2196908 SGTC_1150 3909-7983 10.9 µM -0.0473945655840216 0.479366705730889 no 1771 0.481099380095367 2497 23965914 SGTC_334 1502-1024 68.5 µM -0.0479318815016135 0.479136235556002 no 1772 0.480885265409701 2582 3296216 SGTC_2432 5630864 12.22 µM -0.0484224663567144 0.478925815761264 no 1773 0.480689777370316 2558 5714970 SGTC_788 1182-0090 188 µM -0.0486074399118627 0.478846479127443 no 1774 0.48061607039166 2668 5715185 SGTC_2697 mebhydrolin 72.4 µM -0.0520618198123529 0.47736502539939 no 1775 0.479239717531628 2519 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_222 nsc-310342 10.666 µM -0.0521607836701631 0.477322588030377 no 1776 0.479200290235035 2491 432556 SGTC_831 k061-1017 217 µM -0.0526838775613982 0.477098280843077 no 1777 0.47899189251336 2547 1240153 SGTC_2482 5981709 142.65 µM -0.0534937261505897 0.476751025097375 no 1778 0.478669264650266 2559 877755 SGTC_3243 9134147 49.47 µM -0.0539075232291993 0.47657359945324 no 1779 0.478504421356722 2499 24282180 SGTC_2826 7992541 19.48 µM -0.0547574372718649 0.476209192570909 no 1780 0.478165854816883 2481 2985066 SGTC_1461 k072-0203 53.8 µM -0.0548823325722878 0.476155644463804 no 1781 0.478116103613797 2481 5418714 SGTC_1904 st060225 78 µM -0.0559413054970481 0.47570163360735 no 1782 0.477694282651587 2495 66595 SGTC_1187 1391-0724 117 µM -0.0565234272200271 0.475452075392148 no 1783 0.477462416566611 2527 6997986 SGTC_1609 st001574 46.4 µM -0.0566842295070358 0.475383140417805 no 1784 0.477398368422751 2510 3960012 SGTC_621 3584-0052 32.1 µM -0.0570976787630022 0.475205900593707 no 1785 0.477233692743724 2511 2273927 SGTC_182 3448-4371 550.524 µM -0.0588628064565478 0.474449271035666 no 1786 0.476530691404013 2489 3491403 SGTC_43 0570-0105 72.5 µM -0.0600879271947459 0.473924171786375 no 1787 0.476042802646103 2523 1114046 YDL195W SEC31 SGTC_969 1313-0238 134 µM -0.0607482546208222 0.473641167444062 no 1788 0.47577985049308 2520 5212874 SGTC_1908 st060353 56.5 µM -0.0620579267032385 0.473079905269771 no 1789 0.475258351005465 2552 4227716 SGTC_258 haloperidol 50.781 µM -0.0627435048089277 0.472786120857973 no 1790 0.474985376895643 2526 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3020 9089140 49.47 µM -0.0628818851269388 0.472726823817202 no 1791 0.474930279934066 2551 17217859 SGTC_1637 st007924 17.4 µM -0.0634474792081523 0.472484468659362 no 1792 0.474705090221276 2522 683336 SGTC_13 0199-0087 65 µM -0.0635459348301189 0.47244228179555 no 1793 0.474665891212555 2518 4589825 SGTC_875 0709-0210 25.7 µM -0.0646096662393851 0.471986507501975 no 1794 0.47424239412342 2517 6251364 SGTC_871 0574-0004 149 µM -0.0649530436823366 0.471839389244523 no 1795 0.474105693485697 2542 9551173 SGTC_420 mitomycin C 81.9 mM -0.0657808120603064 0.471484752075648 no 1796 0.473776166450663 2516 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_27 0485-0001 32.618 µM -0.0689478797308414 0.470128110358051 no 1797 0.472515553327953 2512 2054479 SGTC_3224 9130643 49.47 µM -0.0701362717804873 0.469619140610216 no 1798 0.472042598533622 2609 17644395 SGTC_1912 st060209 90.8 µM -0.0709640380896829 0.469264650511506 no 1799 0.471713188375513 2587 688787 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0730519897211394 0.468370596160348 no 1800 0.470882373088007 2597 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0732484583633938 0.468286477043111 no 1801 0.470804202862682 2583 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2592 piperlongumine 83.33 µM -0.0734892166283265 0.468183397014224 no 1802 0.470708412378379 2598 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3276 9139060 49.47 µM -0.0759679814718857 0.467122245530504 no 1803 0.46972228582308 2526 4870619 SGTC_1463 k081-0032 34.1 µM -0.0775917417711177 0.466427244996701 no 1804 0.469076405844505 2541 977755 SGTC_1656 st012921 11 µM -0.077668829723774 0.466394252403734 no 1805 0.469045744729234 2583 6732821 SGTC_1314 1222-0010 41.1 µM -0.0786618449643921 0.465969276143411 no 1806 0.46865079735432 2586 3526027 SGTC_1066 ketoconazole 628 nM -0.0796118866852009 0.465562727379723 no 1807 0.468272970509596 2619 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_576 1073-0113 22.7 µM -0.0799728939343145 0.465408251931622 no 1808 0.468129407204645 2565 5439563 SGTC_3306 9127676 59.7925 µM -0.0816080240289302 0.464708643355139 no 1809 0.467479210164441 2605 41905287 SGTC_2587 piperic acid 92.2 µM -0.0818549428713814 0.464603005812444 no 1810 0.46738103226277 2598 5370536 SGTC_2792 7535235 81.82 µM -0.0822087449751221 0.464451645510209 no 1811 0.467240359750948 2622 1281891 SGTC_2957 9076800 11.52 µM -0.0823050873055211 0.464410430126975 no 1812 0.467202054531821 2602 16459615 SGTC_1499 4480-0877 67.3 µM -0.082509497271287 0.464322984523905 no 1813 0.467120783178443 2551 2861909 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0827852985456234 0.464205000793361 no 1814 0.4670111295294 2549 688664 SGTC_520 3584-0023 682 µM -0.0831461695287623 0.464050630247162 no 1815 0.46686765746947 2657 1340790 SGTC_649 1123-0311 367 µM -0.0837620628119193 0.463787180782925 no 1816 0.466622805734678 2611 693629 YIL048W NEO1 SGTC_2090 5301565 104.445 µM -0.0842290341331062 0.463587443534136 no 1817 0.466437167152523 2573 2056344 SGTC_3169 9102970 49.47 µM -0.0855872175224241 0.46300656124813 no 1818 0.465897280055423 2545 17027839 SGTC_1736 st036774 51 µM -0.087110778545769 0.462355042421306 no 1819 0.465291728957905 2677 1272247 SGTC_2665 lovastatin 100 µM -0.0879727510922007 0.461986482609062 no 1820 0.464949166816073 2579 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0880185916139736 0.461966883158135 no 1821 0.464930949759994 2602 4330530 SGTC_1257 0669-0121 16 µM -0.0880237473203928 0.46196467880386 no 1822 0.46492890088318 2655 4307855 SGTC_2811 7967822 32.47 µM -0.0880674247373433 0.461946004300069 no 1823 0.464911543522761 2644 2232244 SGTC_24 0417-1663 219 µM -0.0883202347910675 0.461837915713403 no 1824 0.464811078380988 2610 4329390 SGTC_68 0986-0284 82.829 µM -0.0894019394192859 0.461375466332362 no 1825 0.464381241105784 2804 423278 YIL048W NEO1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0904677391264279 0.460919867680585 no 1826 0.463957764624973 2562 16486 A toxic proline analog. SGTC_756 0508-1999 28.3 µM -0.0924847806358648 0.460057781448651 no 1827 0.463156441343358 2576 6753853 SGTC_2704 st078022 71.1 µM -0.0926120025990899 0.460003412863491 no 1828 0.46310590401864 2641 54697681 SGTC_1182 1222-0449 220 µM -0.0934905730270032 0.459627974332148 no 1829 0.462756919264578 2633 658318 SGTC_3067 9117431 49.47 µM -0.0936080966125044 0.45957775583047 no 1830 0.462710238846281 2613 17150885 SGTC_1953 st076800 12.1 µM -0.0944330301730314 0.459225275188012 no 1831 0.462382589373656 2610 297591 SGTC_693 4161-2696 114 µM -0.0945971932714523 0.459155134791131 no 1832 0.462317389642294 2673 805759 SGTC_1296 1068-0102 11.9 µM -0.0946056300227632 0.459151530135425 no 1833 0.462314038892727 2664 767053 SGTC_2211 7117706 200 µM -0.0972133653452877 0.458037521011167 no 1834 0.461278477153877 2574 822771 SGTC_3230 9131665 49.47 µM -0.0982374257306313 0.457600138098269 no 1835 0.460871882370612 2567 15943720 SGTC_2076 5212012 200 µM -0.0986484561734965 0.457424598708607 no 1836 0.460708697581291 2560 604802 SGTC_3072 9116419 49.47 µM -0.100321750868397 0.456710068315413 no 1837 0.460044444952988 2641 17170162 SGTC_265 mycophenolic acid 32.932 µM -0.100530533014847 0.456620923924542 no 1838 0.459961571887405 2796 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_384 k007-0144 5.16 µM -0.100665451917822 0.456563318323461 no 1839 0.459908018697318 2657 6824886 SGTC_1546 5-methoxyflavanone 78.7 µM -0.100939360612814 0.456446371804741 no 1840 0.459799298702515 2631 147795 SGTC_2093 5331342 194.4 µM -0.100978210449315 0.456429785001897 no 1841 0.459783878646559 2646 33839 SGTC_217 ketoconazole 989 nM -0.102479899890207 0.455788702367345 no 1842 0.459187883203777 2599 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2519 cryptotanshinone 88.04 µM -0.102999133893887 0.455567064117861 no 1843 0.458981829175578 2617 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2679 rapamycin 1 nM -0.103703725012566 0.455266327162437 no 1844 0.458702235232196 2624 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_774 k060-0086 136 µM -0.103953340501382 0.455159791224475 no 1845 0.458603188382124 2585 5911235 SGTC_2495 cafestol 54.53 µM -0.10427026856881 0.455024530912616 no 1846 0.458477435760052 2801 16667697 An anti-infammatory. SGTC_2067 5224629 34.075 µM -0.10429086449513 0.455015741049638 no 1847 0.458469263728375 2701 2835000 SGTC_360 0957-0399 1.01 µM -0.104760792534252 0.454815192669925 no 1848 0.4582828109127 2697 6752301 YPR165W RHO1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.104957500510013 0.454731248199513 no 1849 0.458204766034925 2594 6708561 SGTC_3340 9146634 11.102 µM -0.105624041698027 0.454446819030856 no 1850 0.45794032446733 2645 4907387 SGTC_1876 myriocin 605 nM -0.10565661738517 0.454432918798511 no 1851 0.45792740096236 2644 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1708 st033234 31.827 µM -0.105818177776554 0.454363980878869 no 1852 0.457863306992835 2688 674664 SGTC_2524 avocatin b 10.57 µM -0.106457458977837 0.454091212693468 no 1853 0.45760970318086 2678 6710748 SGTC_1022 4477-0945 21.3 µM -0.108571866377417 0.45318919332282 no 1854 0.456771038095023 2606 4648966 SGTC_3031 9088762 49.47 µM -0.108594761759652 0.453179427323244 no 1855 0.456761957846706 2586 205253 SGTC_2304 7443016 91.4 µM -0.109255678105632 0.452897526428708 no 1856 0.45649984991497 2573 939854 SGTC_846 0335-0850 148 µM -0.109733163104917 0.45269387933602 no 1857 0.456310499435288 2611 6819598 SGTC_2303 7774051 200 µM -0.109859344218176 0.452640065236158 no 1858 0.456260462965307 2695 2953184 SGTC_1666 st014829 29 µM -0.110462799607746 0.452382713816063 no 1859 0.456021175445841 2573 3858230 SGTC_1320 1313-0481 95.3 µM -0.111360146913554 0.452000065376886 no 1860 0.455665380799147 2608 6813365 YLR208W SEC13 SGTC_3155 9099265 49.47 µM -0.111545255256112 0.451921136682694 no 1861 0.45559199048976 2697 25236499 SGTC_1623 st003709 20.3 µM -0.114219108815351 0.450781240754234 no 1862 0.454532052197392 2596 16192618 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.114930401328086 0.450478076152574 no 1863 0.454250143989434 2713 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3188 9110789 49.47 µM -0.115768131709121 0.450121058711178 no 1864 0.453918153932656 2709 849217 SGTC_2024 5144227 134 µM -0.117227466457717 0.449499227304005 no 1865 0.453339900943806 2733 3475211 SGTC_417 st075190 100 µM -0.117465759843735 0.449397700780173 no 1866 0.453245487924547 2649 222757 SGTC_1829 berberine 14.4 µM -0.117688242336085 0.449302913585648 no 1867 0.453157341645036 2778 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2462 5162487 171.77 µM -0.117766676277041 0.449269498013261 no 1868 0.453126267120298 2582 2259986 SGTC_1117 retinoic acid 1.10837 µM -0.118141854441359 0.449109664116095 no 1869 0.452977630301223 2673 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2596 sinensetin 100 µM -0.119370496646892 0.448586294278737 no 1870 0.452490917201997 2669 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3071 9117417 49.47 µM -0.119639199228898 0.448471845811531 no 1871 0.45238448311583 2700 45595590 YGL055W OLE1 SGTC_1310 1188-0297 994 nM -0.119737950014964 0.448429785974966 no 1872 0.452345368423753 2666 1588352 SGTC_1574 spiramycin 23.7 µM -0.119819366198807 0.448395109710875 no 1873 0.452313120228678 2594 6419898 An antibiotic and protein synthesis inhibitor. SGTC_270 tamoxifen 5.46 µM -0.120181645653363 0.448240814729997 no 1874 0.452169628515074 2697 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2990 9074105 71.4286 µM -0.120299379242028 0.448190673626803 no 1875 0.452122997917564 2606 6502001 SGTC_1152 3909-8331 15.9 µM -0.120322912235996 0.448180651350157 no 1876 0.452113677312795 2624 16001939 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.120929636336673 0.447922269962806 no 1877 0.451873384012678 2613 4174840 SGTC_1985 st071382 65.5 µM -0.121314480553758 0.44775839046849 no 1878 0.451720975453289 2623 6123237 SGTC_1339 1486-1321 22.7 µM -0.12201720807503 0.447459168694932 no 1879 0.451442695013856 2643 3469382 SGTC_3264 9137442 49.47 µM -0.122234103675463 0.44736682045698 no 1880 0.451356809063221 2782 17015726 SGTC_501 nsc-95397 161 µM -0.122447760245618 0.447275854099582 no 1881 0.451272207924492 2794 262093 SGTC_2859 9028643 45.46 µM -0.122627338758797 0.447199398950531 no 1882 0.45120110231343 2729 17151580 SGTC_1641 st009299 47.1 µM -0.123212701540988 0.446950195695953 no 1883 0.450969333916818 2621 4046054 SGTC_3294 9122953 26.2835 µM -0.125261056381335 0.446078326457806 no 1884 0.450158440902925 2634 16459826 SGTC_2717 st081029 62.2815 µM -0.125821510437679 0.445839817982824 no 1885 0.449936607110857 2648 5292846 SGTC_12 0849-0099 9.267 µM -0.127108581713003 0.445292162467788 no 1886 0.449427229666876 2593 6071388 SGTC_1631 benzylvanillin 81.9 µM -0.130777735454532 0.443731494933473 no 1887 0.447975568121963 2762 75506 SGTC_2976 9009005 19.48 µM -0.131337707855092 0.443493387864138 no 1888 0.447754081788299 2722 2993148 SGTC_1330 1469-0054 61.8 µM -0.132587085263854 0.442962211066787 no 1889 0.447259973352353 2793 7102664 SGTC_1888 azatryptophan 97.5 µM -0.133161245350421 0.442718139388112 no 1890 0.447032929782829 2751 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3286 9117135 37.221 µM -0.133924060509931 0.442393905317393 no 1891 0.446731312068193 2689 3438150 SGTC_3207 9114163 49.47 µM -0.134465596345853 0.442163749279528 no 1892 0.446517207063236 2822 849233 SGTC_2488 5268135 45.7 µM -0.135392840585662 0.441769710185841 no 1893 0.446150642198899 2764 1270356 YLR208W SEC13 SGTC_289 k017-0060 526 µM -0.13565271933433 0.441659283167336 no 1894 0.446047913304697 2661 5512909 SGTC_3197 9113331 49.47 µM -0.135700047491978 0.441639173094511 no 1895 0.446029205087611 2799 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2942 9052777 62.25 µM -0.13576051129285 0.441613481811765 no 1896 0.4460053046931 2669 6469503 SGTC_1475 4092-1048 11.7 µM -0.136539332395175 0.441282579969639 no 1897 0.445697466465335 2693 2881759 SGTC_2549 cedrol 20.94 µM -0.137302977774982 0.440958165708797 no 1898 0.445395658402906 2719 6708665 A sedative which affects the nervous system. SGTC_2345 9052315 157.45 µM -0.137485758622057 0.440880522035437 no 1899 0.445323424410977 2758 6469265 SGTC_949 1165-0505 146 µM -0.137751796060199 0.440767515766686 no 1900 0.445218291113612 2666 6244267 SGTC_2111 5486399 200 µM -0.138325382759054 0.440523886433458 no 1901 0.444991632897399 2643 689674 SGTC_3004 9076122 71.4286 µM -0.138912403018171 0.44027457454359 no 1902 0.4447596849026 2761 44782551 SGTC_1981 st071826 47 µM -0.138987976149267 0.440242479788403 no 1903 0.444729825233802 2744 11838600 SGTC_2807 7945238 51.95 µM -0.140349868337024 0.439664172457257 no 1904 0.444191782486274 2762 17148797 SGTC_378 3970-0959 8.33 µM -0.140614576085851 0.439551783138414 no 1905 0.444087216301363 2767 6615653 SGTC_2970 9090938 41.86 µM -0.141580607281966 0.43914166809622 no 1906 0.443705642878218 2761 17217104 SGTC_667 1498-1044 59 µM -0.141947990242155 0.438985717915451 no 1907 0.443560543671123 2696 6739982 SGTC_832 4083-0019 164 µM -0.141960092698694 0.438980580711659 no 1908 0.44355576389149 2779 1990758 SGTC_1768 st044301 37.178 µM -0.142240310066827 0.43886163800639 no 1909 0.443445096321063 2703 3931349 SGTC_1968 st069590 43.6 µM -0.142979740392875 0.438547801612152 no 1910 0.443153090804364 2769 6384066 SGTC_1943 st076331 65.2 µM -0.143045151779749 0.438520040916147 no 1911 0.443127260935214 2660 24208415 SGTC_3257 9139206 32.98 µM -0.143142056362619 0.438478915013999 no 1912 0.44308899537084 2771 4910041 SGTC_613 3914-0030 117 µM -0.143188995589694 0.438458994439945 no 1913 0.443070460256474 2613 1145395 SGTC_2518 prenyletin 46.28 µM -0.143400569396571 0.438369206408076 no 1914 0.442986916654581 2704 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1857 st056007 79.3 µM -0.143612621957038 0.438279218384978 no 1915 0.442903186551768 2738 619834 SGTC_1837 st055472 66.5 µM -0.143849720822189 0.438178605325849 no 1916 0.442809569799342 2818 676091 SGTC_3085 9117376 49.47 µM -0.144136200678172 0.438057042742359 no 1917 0.442696459584036 2733 16480349 SGTC_3208 9114115 49.47 µM -0.144600997346906 0.437859827060345 no 1918 0.442512954871198 2743 650895 SGTC_1283 0922-0125 16.4 µM -0.146866770693336 0.436898669351241 no 1919 0.441618590301704 2772 3360884 SGTC_1867 st057372 64 µM -0.147022126692111 0.436832779771462 no 1920 0.441557277762301 2677 688837 SGTC_2944 9067346 25.62 µM -0.147245213287127 0.436738167359231 no 1921 0.441469237228405 2809 6473075 SGTC_1324 1418-0026 34.4 µM -0.148089890668029 0.436379967263144 no 1922 0.441135913777874 2761 1372513 SGTC_1085 doxorubicin 7.67 µM -0.149603372060574 0.435738279888402 no 1923 0.440538773804187 2732 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_531 3788-1495 174 µM -0.150044285461219 0.43555137271842 no 1924 0.440364837988677 2631 2896655 SGTC_2875 9039966 71.43 µM -0.150103890907456 0.435526106535476 no 1925 0.440341325133499 2781 6463691 SGTC_127 0180-0333 59.125 µM -0.150419233480272 0.435392440193601 no 1926 0.44021693389163 2642 771601 SGTC_230 MPP+ 141.667 µM -0.151220650551148 0.435052771491479 no 1927 0.439900830416642 2704 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_372 0155-0182 15.9 µM -0.152182718753016 0.434645076512899 no 1928 0.43952141181985 2687 771486 SGTC_283 0987-0079 11.7 µM -0.152577651756039 0.434477736118864 no 1929 0.439365674967669 2750 411556 SGTC_2415 st077333 57.7 µM -0.153107896062421 0.434253080296813 no 1930 0.439156594570308 2737 2766255 SGTC_2265 7929201 200 µM -0.154828015016354 0.433524440608888 no 1931 0.438478452365571 2645 1265108 SGTC_1913 st060213 96.1 µM -0.156177228395981 0.432953073877357 no 1932 0.437946662788142 2795 688959 SGTC_3233 9132340 49.47 µM -0.156603567472252 0.432772556301482 no 1933 0.437778645401749 2693 17682950 SGTC_1285 0929-0069 65.5 µM -0.156746673408584 0.432711966507643 no 1934 0.437722250819821 2717 1206237 SGTC_1457 k015-0032 57.3 µM -0.157594294843521 0.432353123535802 no 1935 0.437388249724589 2668 4302660 SGTC_186 3455-3465 67.277 µM -0.15802998809002 0.432168693238297 no 1936 0.437216584269241 2683 755278 SGTC_1040 k898-0338 155 µM -0.1590272770593 0.43174659343598 no 1937 0.436823691654544 2770 20969351 SGTC_840 0245-0196 390 µM -0.159746187433024 0.43144236490406 no 1938 0.436540507877287 2817 3827528 SGTC_3291 9121177 71.43 µM -0.159890131508761 0.431381455522506 no 1939 0.436483811211468 2724 17015612 SGTC_2219 9098279 200 µM -0.161168965603234 0.430840393602378 no 1940 0.435980161700929 2711 902349 SGTC_2772 vinpocetine 57.06 µM -0.161504523125785 0.430698444023228 no 1941 0.435848024592384 2854 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_574 1315-0397 40 µM -0.162085411880393 0.430452734113261 no 1942 0.435619296960881 2687 6794277 SGTC_1873 rapamycin 2 nM -0.16309011180313 0.430027820089978 no 1943 0.435223742599604 2700 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2671 danthron 100 µM -0.164097821916717 0.429601714367859 no 1944 0.434827068215027 2731 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1057 3448-5381 134 µM -0.164548552137213 0.42941115161779 no 1945 0.434649664256552 2825 5497911 SGTC_1515 3460-0031 42.1 µM -0.164654679865113 0.429366284614867 no 1946 0.434607895109039 2726 2876596 SGTC_2361 9034121 116 µM -0.167481025832089 0.428171744253004 no 1947 0.433495787928148 2745 6496917 SGTC_1120 ficusin 1.78878 µM -0.1675010264062 0.428163293446271 no 1948 0.433487919991698 2837 6199 A DNA cross-linker. SGTC_1259 0671-0132 43 µM -0.167545254374362 0.428144605999137 no 1949 0.433470521442588 2732 X1259 SGTC_2634 4'-methoxyflavone 100 µM -0.168675331581373 0.427667174267828 no 1950 0.433026011637257 2761 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2155 5570423 76 µM -0.168849376668503 0.427593653598644 no 1951 0.432957559451283 2718 797402 SGTC_2136 5328288 199.296 µM -0.168953804280851 0.427549542167208 no 1952 0.432916488884869 2741 262395 SGTC_2010 4012422 159 µM -0.169129585162396 0.427475292335052 no 1953 0.432847357270217 2781 952393 SGTC_460 trequinsin 123 µM -0.17049307429167 0.426899442055993 no 1954 0.432311190271505 2732 5537 A vasodilator. SGTC_1634 st006576 41 µM -0.170634945550599 0.426839533669101 no 1955 0.432255409152427 2835 3915356 SGTC_1723 st034307 2.5525 µM -0.17094925725774 0.42670681436822 no 1956 0.432131832493537 2786 867466 SGTC_2686 alizarin 95.37 µM -0.171044519541203 0.426666591148518 no 1957 0.432094379918594 2772 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3217 9129673 49.47 µM -0.172121421133124 0.426211937053701 no 1958 0.43167103622539 2869 17248312 SGTC_828 2074-0507 139 µM -0.172231470645468 0.426165481067399 no 1959 0.431627778775135 2841 X828 SGTC_74 000s-0487 160.283 µM -0.173011181726596 0.42583636544425 no 1960 0.431321319209634 2678 677548 SGTC_3042 9091578 49.47 µM -0.17514822133422 0.424934587662076 no 1961 0.430481584348592 2690 25236497 SGTC_232 clozapine 119 µM -0.178058322243061 0.423707229437389 no 1962 0.429338586475161 2708 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2536 dehydroabietamide 32.04 µM -0.178138179825831 0.423673559240933 no 1963 0.429307229184223 2870 3983547 SGTC_2082 5219693 150 µM -0.178327708055966 0.423593651055075 no 1964 0.429232809836408 2717 2834649 SGTC_2690 usnic acid 100 µM -0.179594813012197 0.423059499867414 no 1965 0.428735338544151 2910 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2237 6667747 47.222 µM -0.180445596063868 0.422700929480019 no 1966 0.428401380635425 2755 729940 YDL015C TSC13 SGTC_2433 5607874 27.82 µM -0.181412017492556 0.42229369992839 no 1967 0.428022093393134 2728 2252428 SGTC_2871 9038510 12.99 µM -0.182127837775598 0.421992121915551 no 1968 0.427741201344496 2751 4945164 SGTC_2321 7390090 138.78 µM -0.182543755948556 0.421816914884688 no 1969 0.427578009441108 2818 649046 SGTC_777 1315-0167 517 µM -0.182713316324266 0.421745491403004 no 1970 0.42751148336872 2816 4221767 SGTC_810 3825-7150 143 µM -0.185424173746034 0.420603954999284 no 1971 0.426448174632086 2911 22330411 YGL099W LSG1 SGTC_1669 st015249 58.4 µM -0.186036845024462 0.420346052517856 no 1972 0.426207933753157 2805 722793 SGTC_3139 9095020 49.47 µM -0.1860718645922 0.420331312148203 no 1973 0.426194202694272 2681 25236292 SGTC_3121 9125696 49.47 µM -0.18713767908625 0.419882745086278 no 1974 0.425776343165839 2693 1235365 SGTC_1216 1165-0504 9.65 µM -0.187245343199288 0.419837438499163 no 1975 0.425734137374304 2814 6304004 SGTC_553 k007-0256 45.7 µM -0.187875074531352 0.419572459915059 no 1976 0.425487291214876 2780 6287000 SGTC_3275 9138069 49.47 µM -0.187963544409286 0.419535236445492 no 1977 0.42545261455742 2819 17617007 SGTC_3330 9141424 71.43 µM -0.189788035809703 0.418767747471863 no 1978 0.424737615772361 2870 27261020 SGTC_1563 conessine 56.1 µM -0.190211967793271 0.418589460755576 no 1979 0.42457151669108 2853 441082 An anti-amoebic, histamine inhibitor. SGTC_1054 3429-0080 167 µM -0.190279013877362 0.418561265720022 no 1980 0.424545248861031 2893 1162877 SGTC_662 k832-1615 104 µM -0.190326456336772 0.418541314892153 no 1981 0.424526661692159 2817 5878478 SGTC_1208 2323-2347 50.3 µM -0.190472823828408 0.418479764753068 no 1982 0.424469318393912 2875 5412760 SGTC_3079 9117512 49.47 µM -0.192497608879643 0.417628511973314 no 1983 0.423676220362801 2697 7185044 SGTC_2508 celastrol 40.54 µM -0.19318041042862 0.417341537824396 no 1984 0.423408839988951 2727 122724 Celastrol is a natural product and antioxidant. SGTC_169 k015-0017 16.025 µM -0.193318547829398 0.417283485509587 no 1985 0.423354750621411 2890 1840002 SGTC_1880 MG-132 525 µM -0.193453595459328 0.417226733415626 no 1986 0.423301872487266 2845 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1010 4112-3296 15.2 µM -0.193962888901364 0.417012724678049 no 1987 0.423102470191221 2914 704384 SGTC_218 alverine citrate 93.75 µM -0.196156813010371 0.416091103980607 no 1988 0.422243714774551 2867 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_5 0352-0601 109.883 µM -0.196954681669667 0.415756050481241 no 1989 0.421931500928529 2801 762456 SGTC_2803 7707263 71.43 µM -0.197100305273862 0.415694904538013 no 1990 0.421874522269844 2780 2199229 SGTC_2513 baicalein 25.65 µM -0.197127464142152 0.415683501017633 no 1991 0.421863895905041 2793 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1919 st067113 52.3 µM -0.197419896688188 0.415560718350838 no 1992 0.42174948035014 2889 1268243 SGTC_852 0418-0143 439 µM -0.19796868282104 0.415330323628776 no 1993 0.421534783132266 2854 5369229 SGTC_354 2783-3500 4.88 µM -0.199774915345142 0.414572226122105 no 1994 0.420828310251135 2780 6740761 SGTC_1448 4255-0083 152 µM -0.200235427582828 0.414378994375231 no 1995 0.420648230492887 2921 5399660 SGTC_394 menadione 8.33 µM -0.2004206434748 0.414301283300654 no 1996 0.42057580792711 2769 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_748 act1.228 77.9 µM -0.200744417026185 0.414165445616625 no 1997 0.420449213417237 2757 4421505 YNR035C ARC35 SGTC_3254 9136651 49.47 µM -0.201639159368259 0.413790114077603 no 1998 0.420099414608212 2766 16454030 SGTC_115 0527-0192 112.043 µM -0.201800263475806 0.413722541578111 no 1999 0.420036437781327 2845 4233931 SGTC_2451 5856223 45.7 µM -0.202220897530373 0.413546125508397 no 2000 0.419872018370063 2796 2179896 SGTC_873 0591-4978 488 µM -0.202886677285224 0.413266929763012 no 2001 0.419611803855173 2985 3305145 SGTC_1345 1488-0192 31.4 µM -0.203579636169736 0.412976382986323 no 2002 0.419341003931999 2854 658348 SGTC_946 3434-1334 87.4 µM -0.204579776869284 0.412557123775226 no 2003 0.418950228468775 2911 4047976 SGTC_587 k089-0003 57 µM -0.205114018335151 0.412333210471147 no 2004 0.418741522116765 2747 9659696 SGTC_1425 4048-4433 7.33 µM -0.205804768217169 0.412043743070757 no 2005 0.418471708217434 2822 23734946 SGTC_149 3970-0822 46.1 µM -0.206675403669347 0.411678960547385 no 2006 0.418131683844593 2771 3114250 YBL034C STU1 SGTC_3314 9135860 59.4275 µM -0.207100008075078 0.41150108566565 no 2007 0.417965877895435 2803 25252478 SGTC_2979 9012552 45.46 µM -0.210566731269128 0.410049492818944 no 2008 0.416612687414987 2871 17100905 SGTC_2107 5363541 170.161 µM -0.211188435397558 0.40978930138232 no 2009 0.416370117233759 2803 244052 SGTC_1173 0443-0020 122 µM -0.21322024542383 0.408939239499494 no 2010 0.415577588886276 2789 5331295 SGTC_731 3966-0296 387 µM -0.2132353333106 0.408932928676385 no 2011 0.41557170498136 2790 660956 SGTC_2722 naftopidil 47.16 µM -0.213484591131689 0.408828674815308 no 2012 0.415474503299498 2808 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_676 falcarinol 140 µM -0.213591055659529 0.408784147232847 no 2013 0.415432987497612 2937 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2215 7188065 200 µM -0.214896683770389 0.408238178986654 no 2014 0.414923935231018 2911 940217 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.21658213632066 0.407533644846677 no 2015 0.414267004231127 2771 803109 SGTC_3135 9127742 49.47 µM -0.217261890936802 0.407249585853887 no 2016 0.414002127184618 2855 3643468 SGTC_2123 5259487 200 µM -0.217585327512611 0.407114443801483 no 2017 0.413876108777036 2907 2173474 SGTC_2005 4024620 188 µM -0.217824112979744 0.407014678759352 no 2018 0.413783078098667 2783 236743 SGTC_1079 idarubicin 2.36 µM -0.21923919230144 0.406423579832683 no 2019 0.413231863495927 2813 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3342 9147791 14.508 µM -0.219961640442484 0.406121884997917 no 2020 0.412950514770695 2783 1838168 SGTC_766 1391-0721 126 µM -0.220275270355627 0.405990930272388 no 2021 0.412828389287622 2982 1020919 YIL115C NUP159 SGTC_2515 chrysin 20.77 µM -0.220297256055035 0.405981750639206 no 2022 0.412819828513139 2902 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2028 5153890 36.43 µM -0.221664098438548 0.405411158107957 no 2023 0.412287690067337 2810 2830968 YPR165W RHO1 SGTC_2180 6301957 200 µM -0.222500793270624 0.405061976372913 no 2024 0.411962027902643 2881 845462 SGTC_671 0560-0003 407 µM -0.223194640530588 0.404772467181661 no 2025 0.411692011489911 2857 3238678 SGTC_692 k241-0027 77.8 µM -0.224478415284702 0.404236947072884 no 2026 0.411192530244995 2964 3600480 SGTC_1606 st000094 49.2 µM -0.224821940894877 0.404093677494796 no 2027 0.411058898308748 2867 1242210 SGTC_346 4513-0042 7.16 µM -0.22597311268982 0.403613667730979 no 2028 0.41061116621588 2804 2827372 SGTC_1305 1181-0477 144 µM -0.22719559622156 0.403104081681567 no 2029 0.410135825937466 2940 6252086 SGTC_2077 5212015 200 µM -0.227241847867598 0.403084805142427 no 2030 0.410117844421379 2748 780900 SGTC_34 0469-0683 81.75 µM -0.2282348255241 0.402671013559995 no 2031 0.40973184448076 2898 3690923 SGTC_3137 9097352 49.47 µM -0.228459972068444 0.402577206104194 no 2032 0.409644335476323 3111 44120435 SGTC_1638 st008370 60.6 µM -0.230447920392696 0.401749170120963 no 2033 0.408871863951423 2779 24207134 SGTC_2158 5657123 3.6195 µM -0.232553585280353 0.400872582758729 no 2034 0.408054036356665 2788 2858827 SGTC_1159 4092-0538 61.2 µM -0.232728240467842 0.400799896227155 no 2035 0.40798621926576 2825 717301 SGTC_2289 7946404 165.07 µM -0.23337616703433 0.400530277602292 no 2036 0.407734659109201 2819 1246120 YPR165W RHO1 SGTC_1828 st055811 49 µM -0.23461003158588 0.400016966514131 no 2037 0.407255711384951 2969 5877589 SGTC_591 4299-0174 154 µM -0.23552461473298 0.399636593952388 no 2038 0.406900788161119 2864 5509088 SGTC_2998 9066762 71.4286 µM -0.235582310442481 0.399612601658454 no 2039 0.40687840068811 2983 4945196 SGTC_213 1246-0773 967 nM -0.235816366685564 0.399515275152582 no 2040 0.406787583749473 2858 6251622 SGTC_1064 honokiol 6.76 µM -0.236572731840057 0.39920080211161 no 2041 0.40649413829413 2903 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_468 gf-109203x 121 µM -0.236712102375875 0.399142863319601 no 2042 0.406440072713764 2904 2396 A protein kinase C inhibitor. SGTC_371 0195-0006 7.36 µM -0.237210041547571 0.398935879373515 no 2043 0.406246923289834 2759 3928593 SGTC_1808 st050063 61.5 µM -0.238707131360347 0.39831373867542 no 2044 0.405666343285082 2980 4011993 SGTC_2470 5664817 21.68 µM -0.238819501053512 0.398267051976607 no 2045 0.405622774028688 2811 2859561 SGTC_2611 pyromycin 23.93 µM -0.239346448388076 0.398048138436179 no 2046 0.405418475616339 2873 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_407 eburnamonine 100 µM -0.239534138966394 0.397970172529566 no 2047 0.405345713867783 2807 3195 SGTC_1211 1056-0033 32.3 µM -0.240202188659921 0.397692700468719 no 2048 0.405086758520236 2918 6741922 SGTC_1763 st044482 94.5 µM -0.241344443980926 0.397218388746531 no 2049 0.404644083700426 2968 88505 SGTC_2465 5809242 33.21 µM -0.242298235005854 0.396822451594866 no 2050 0.404274540648724 2818 2731748 SGTC_1562 morin hydrate 59.1 µM -0.243848460369002 0.39617915002948 no 2051 0.403674093490516 3023 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_513 4245-1575 41.7 µM -0.244403436200426 0.395948918684187 no 2052 0.403459190379262 2954 719745 SGTC_2379 9035213 200 µM -0.244771185612488 0.395796378079008 no 2053 0.403316802945945 2982 646551 SGTC_357 1325-0123 420 µM -0.245053905358261 0.395679118200274 no 2054 0.403207346524152 2971 1098503 SGTC_3355 9151058 44.0485 µM -0.245848056194176 0.395349789447384 no 2055 0.402899927485701 2821 17015728 SGTC_88 0180-0332 8.668 µM -0.246038887451541 0.395270664196936 no 2056 0.402826064861516 2808 3101745 SGTC_1658 st012944 20 µM -0.247734669075696 0.394567724407208 no 2057 0.402169852891118 2900 24207260 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.248202259284903 0.394373957961998 no 2058 0.40198895919045 2778 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3289 9119912 71.43 µM -0.249231108223009 0.393947701504915 no 2059 0.401591008799554 2944 17014829 SGTC_287 k060-0039 29.6 µM -0.250506300508201 0.393419560282877 no 2060 0.401097916450697 2987 5861974 SGTC_818 4072-2707 53.5 µM -0.250607367579954 0.393377710115541 no 2061 0.401058842482274 2814 882871 SGTC_1739 st037196 92.5 µM -0.250820641780169 0.393289400914727 no 2062 0.400976390889101 3024 612214 SGTC_1830 st055982 50.3 µM -0.25323382389792 0.39229057223543 no 2063 0.400043765215667 2888 455313 An antimicrobial agent. SGTC_1382 3002-2117 298 µM -0.254160347780101 0.39190726721754 no 2064 0.399685841403057 3007 1497314 SGTC_718 1130-0073 349 µM -0.254365940681488 0.391822227177517 no 2065 0.399606430585634 3021 6740020 SGTC_1161 k007-0610 110 µM -0.255186122874166 0.391483024103926 no 2066 0.399289674342439 2947 5843850 SGTC_73 0327-0325 16.231 µM -0.255388596488873 0.391399299697989 no 2067 0.399211488762757 2994 53298 SGTC_2196 6573537 42.6665 µM -0.256805867580961 0.390813388207237 no 2068 0.398664320137402 2964 2903087 SGTC_1111 tnp00062 510.699 nM -0.25742796688446 0.390556285426915 no 2069 0.398424207861767 3013 676306 SGTC_1284 0929-0043 16 µM -0.258346150348452 0.390176903683399 no 2070 0.398069885973454 2919 1239883 SGTC_2073 5212005 126 µM -0.258459233316712 0.390130186462723 no 2071 0.398026253692188 2809 691789 SGTC_1615 st002656 86.5 µM -0.259397748354091 0.389742525227255 no 2072 0.397664183414751 2836 1584458 SGTC_1963 st076565 50.3 µM -0.260484408808161 0.389293808339619 no 2073 0.397245070149027 2897 4914280 SGTC_1836 st055642 81 µM -0.261999281950578 0.388668515112031 no 2074 0.396660997889715 2879 8571 SGTC_1351 1496-0003 46.5 µM -0.262181213448297 0.38859343872578 no 2075 0.39659086821343 2995 3891978 SGTC_1987 st072290 61.9 µM -0.262851106732391 0.38831703448644 no 2076 0.396332671305086 2924 54697379 SGTC_2071 5230951 39.92 µM -0.26290759110114 0.38829373109052 no 2077 0.39631090261656 2930 1799272 SGTC_2941 9056145 11.23 µM -0.263219753462144 0.388164951509778 no 2078 0.39619060321415 2854 2119517 SGTC_2870 9038528 12.99 µM -0.265861297323448 0.387075701564072 no 2079 0.395173016463022 2995 6463316 SGTC_2102 5377816 72.7585 µM -0.267234595255507 0.386509767843271 no 2080 0.394644270621456 3067 1379702 SGTC_679 0422-0091 41.4 µM -0.269552537901516 0.385555095580915 no 2081 0.393752259155706 2870 627384 YHR062C RPP1 SGTC_931 2812-0076 566 µM -0.270655559621157 0.38510104592333 no 2082 0.393327979827311 2856 3450959 SGTC_2650 prasterone 100 µM -0.270978317405115 0.384968215139182 no 2083 0.393203854382899 2893 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.271467314047951 0.384766994568511 no 2084 0.393015817867697 2929 688788 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.273196250868681 0.384055791735159 no 2085 0.392351180888472 2877 229346 A bile salt which induces apoptosis. SGTC_1297 1068-0111 14.1 µM -0.273222350628482 0.384045058512601 no 2086 0.392341150032726 2896 767057 SGTC_811 0416-0114 265 µM -0.273587430059667 0.383894933169925 no 2087 0.392200847464215 2968 6612453 SGTC_2837 9008476 45.46 µM -0.273617912885039 0.383882399029089 no 2088 0.392189133335704 3081 2992805 SGTC_2446 5162541 200 µM -0.273793836096528 0.383810064069276 no 2089 0.392121530386174 2853 1549321 SGTC_1061 3448-9325 110 µM -0.275118586148656 0.383265492159467 no 2090 0.391612566341967 2897 723482 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.275836635939134 0.382970415979771 no 2091 0.391336771737333 2851 5355888 SGTC_2114 5491910 81.25 µM -0.276003154328737 0.382901996420432 no 2092 0.391272821750454 3009 2849228 SGTC_1381 2324-0066 62.1 µM -0.276210804063136 0.382816681813683 no 2093 0.391193079734426 3013 10885928 SGTC_890 0929-0006 47.2 µM -0.277520061797382 0.382278893560219 no 2094 0.390690401733755 2898 1378169 SGTC_1618 st003135 44.5 µM -0.277520287857751 0.382278800723657 no 2095 0.390690314955608 2844 1270615 SGTC_1431 4049-0260 9.09 µM -0.278119698432521 0.382032663668159 no 2096 0.390460237440197 2860 3854841 SGTC_1286 0929-0070 131 µM -0.278280391778293 0.381966685966222 no 2097 0.390398563486507 2998 1420408 SGTC_60 0986-0278 202 µM -0.278493464908844 0.381879207384301 no 2098 0.390316790474156 2893 3110598 SGTC_2338 7999974 200 µM -0.279297548761961 0.381549139803662 no 2099 0.390008243638634 2956 315925 SGTC_411 enrofloxacin 100 µM -0.27936444570691 0.381521683220436 no 2100 0.389982576747882 3062 71188 A bacterial gyrase inhibitor. SGTC_1896 st058441 89 µM -0.279893190547018 0.381304690910228 no 2101 0.389779725835036 2942 688759 SGTC_2188 6126565 140.678 µM -0.280126212511152 0.381209072551404 no 2102 0.389690337386392 3007 874518 SGTC_2569 tetrandrine 100 µM -0.280593377337064 0.381017397731549 no 2103 0.389511148085702 2952 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3099 9120367 49.47 µM -0.280603149770261 0.381013388474585 no 2104 0.389507399947426 2890 24824940 SGTC_2325 6158266 200 µM -0.283037710059032 0.380014980172794 no 2105 0.388573964973931 2987 3623240 SGTC_1004 4084-0029 199 µM -0.28421912832258 0.37953077046445 no 2106 0.388121228696366 3072 716894 YLR208W SEC13 SGTC_560 2332-1943 155 µM -0.285343002627798 0.379070320690272 no 2107 0.387690685143473 2892 21177716 SGTC_2693 st077581 40.7 µM -0.287996317297251 0.377983942858227 no 2108 0.386674778836222 3046 25238761 SGTC_399 oxolinic acid 75 µM -0.28824303103558 0.377882976814613 no 2109 0.386580355929324 2905 4628 A DNA gyrase inhibitor. SGTC_104 0074-0074 590.992 µM -0.288945030833365 0.377595733474669 no 2110 0.386311721540277 2839 3943124 SGTC_2669 eugenol 100 µM -0.289895070612716 0.37720710527322 no 2111 0.385948256431257 2994 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2537 larixol 68.93 µM -0.290546554596069 0.376940677693567 no 2112 0.385699070282491 2902 6708759 SGTC_3323 9138564 53.9225 µM -0.292989445267677 0.375942168188311 no 2113 0.384765109662139 3089 43912313 YNL103W MET4 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.293071867790723 0.375908493164431 no 2114 0.384733609688114 3152 6728940 SGTC_1387 3342-1166 1.8 µM -0.293776856583886 0.37562049748992 no 2115 0.384464210452618 2984 3418228 SGTC_292 k038-0015 474 µM -0.294224369535087 0.375437719468515 no 2116 0.384293230082128 3047 46368540 SGTC_2443 5493264 126.67 µM -0.294497366923732 0.375326232684553 no 2117 0.384188937573591 3087 5340055 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.294978551927261 0.375129751514382 no 2118 0.384005132089913 2932 641818 YHR062C RPP1 SGTC_108 0509-0257 621.132 µM -0.295531374075226 0.374904058905695 no 2119 0.383793994491673 3014 536624 SGTC_2078 5212016 200 µM -0.296072018821252 0.374683379213366 no 2120 0.383587541130021 2915 1899708 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.296834623516982 0.374372169963523 no 2121 0.383296385200538 2937 279621 SGTC_947 3447-0010 211 µM -0.297126692514654 0.374253001991665 no 2122 0.383184893207646 2920 748350 SGTC_3221 9128209 49.47 µM -0.297752208906629 0.37399782354978 no 2123 0.382946146336465 2963 16460723 SGTC_3335 9143315 29.6265 µM -0.298417772682148 0.373726368463216 no 2124 0.382692163019573 2954 4899691 SGTC_561 1550-0330 72.9 µM -0.298628997156358 0.373640232091559 no 2125 0.382611568972734 2939 6812934 SGTC_1036 k216-0215 33.5 µM -0.299324409363826 0.373356690801027 no 2126 0.382346265941193 2911 622330 SGTC_2206 7254556 146.969 µM -0.299567395559198 0.37325763388985 no 2127 0.382253578575315 2971 4398905 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.299589679749387 0.373248549829815 no 2128 0.382245078582794 3149 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3303 9125618 40.5795 µM -0.300490252557801 0.37288149397213 no 2129 0.381901615215664 3012 22695467 SGTC_745 0469-0705 296 µM -0.301058147059653 0.372650090579078 no 2130 0.381685077538617 3139 3486736 SGTC_1329 1447-1697 50.6 µM -0.301300718026203 0.372551262728624 no 2131 0.381592596720399 3023 2840515 SGTC_3273 9137859 49.47 µM -0.302364549326984 0.372117937559777 no 2132 0.381187088129207 3008 2377234 SGTC_1127 asiatic acid 681.4 nM -0.303737346295516 0.371559002240665 no 2133 0.38066400155852 2926 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1797 st048695 56.8 µM -0.305111305109035 0.370999864888085 no 2134 0.380140690624713 3066 592262 YIL048W NEO1 SGTC_249 wiskostatin 11.211 µM -0.30589516069748 0.37068099399269 no 2135 0.379842235335749 2992 2775510 A n-wasp and actin depolymerizer. SGTC_2930 9013230 14.89 µM -0.306987855044954 0.370236636328458 no 2136 0.379426308226641 3078 2995857 SGTC_102 gallobenzophenone 83.616 µM -0.308169708619032 0.369756215858844 no 2137 0.378976600277088 3123 70837 SGTC_586 0957-0265 8.15 µM -0.308241571776689 0.369727010215018 no 2138 0.378949260851235 3042 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_822 1487-0950 154 µM -0.30836099889819 0.36967847593635 no 2139 0.378903827658819 3103 1958375 SGTC_3069 9117009 49.47 µM -0.308807553219637 0.369497018039458 no 2140 0.378733961574885 3002 41904981 SGTC_2991 9074669 71.4286 µM -0.30958628201773 0.369180650194038 no 2141 0.378437794741698 3141 17333109 SGTC_2713 st079149 53.4 µM -0.310351755315784 0.368869753887897 no 2142 0.378146738831133 3032 3103253 SGTC_1403 3909-7815 62.9 µM -0.310619357334677 0.368761087790065 no 2143 0.37804500481764 2928 6615483 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.311283291145112 0.368491527164319 no 2144 0.377792634241237 2974 97141 SGTC_135 0933-0004 26.348 µM -0.31185280899084 0.368260351470309 no 2145 0.377576194051834 3057 21230617 YGL099W LSG1 SGTC_264 promethazine 12.5 mM -0.311866152184448 0.368254935842634 no 2146 0.377571123550416 3005 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2786 7743617 45.45 µM -0.312217195359109 0.368112466680345 no 2147 0.377437732415054 2989 583674 SGTC_859 0439-0102 54.6 µM -0.3140366791899 0.367374329053364 no 2148 0.376746590462455 3096 610143 SGTC_1915 st067105 30.6 µM -0.314187931900169 0.367312990083943 no 2149 0.376689153949713 2938 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2272 7805186 180 µM -0.315046830150422 0.366964737043566 no 2150 0.376363048806535 3097 2956062 YPR165W RHO1 SGTC_1881 5652484 16 µM -0.315291717558343 0.366865463849204 no 2151 0.376270086493545 3105 2255129 SGTC_3288 9119690 36.221 µM -0.316203722736205 0.366495830812363 no 2152 0.375923941137248 2988 17595618 YKL019W RAM2 SGTC_2233 sulbentine 40.3845 µM -0.316241137813626 0.366480669232053 no 2153 0.375909742628848 3011 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_973 1325-0077 65.9 µM -0.317773614179336 0.365859848524501 no 2154 0.375328333443774 3009 2835149 SGTC_998 3996-0085 177 µM -0.319208070828491 0.365279054607658 no 2155 0.374784368612614 3009 715391 SGTC_6 0844-0013 19.835 µM -0.319509925931463 0.365156876464681 no 2156 0.374669932867295 3040 1584900 SGTC_919 tnp00227 403.569 nM -0.319840943590335 0.365022910289786 no 2157 0.374544454045346 2988 1269246 A methoxyflavone. YNL221C POP1 SGTC_1771 st048882 4.1505 µM -0.322556719974419 0.363924431634218 no 2158 0.373515487731102 2965 4580403 SGTC_1875 nocodazole 6 µM -0.323300412852027 0.363623816840584 no 2159 0.37323387068166 3081 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2551 apiole 73.87 µM -0.324394014882933 0.363181914637989 no 2160 0.372819875201732 2927 10659 A possible DNA adduct former. SGTC_546 peri-Naphthalide 147 µM -0.324469215701065 0.363151534209672 no 2161 0.372791412468083 3018 223824 A penicillin ester. SGTC_2056 5235370 200 µM -0.324501508278169 0.363138488574299 no 2162 0.37277919027402 2994 5511916 SGTC_2781 5567276 71.43 µM -0.325215509927954 0.362850085009144 no 2163 0.372508985472588 3132 2853274 SGTC_2160 5660466 132.927 µM -0.325336079726514 0.362801391448783 no 2164 0.372463363560867 3046 2859134 SGTC_555 4296-0685 37 µM -0.327714551832289 0.361841271392294 no 2165 0.371563749856836 3023 2908540 YHR072W ERG7 SGTC_2936 9038235 15.59 µM -0.327763921645211 0.361821351418953 no 2166 0.371545084035304 2933 4749415 SGTC_680 0417-1641 114 µM -0.328232079096539 0.361632475577423 no 2167 0.37136809729994 2956 2835990 SGTC_351 caspofungin 25 nM -0.329840253797006 0.360983922356774 no 2168 0.370760334873454 3017 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1719 st032227 49.2 µM -0.330727531406289 0.360626267215993 no 2169 0.37042515221861 2981 3125804 SGTC_1748 st037455 53.6035 µM -0.331095660236045 0.360477912923078 no 2170 0.370286114788617 3159 580690 SGTC_1847 st056231 15 µM -0.331779685540762 0.360202309523642 no 2171 0.370027812413286 2975 5393180 SGTC_3134 9127454 49.47 µM -0.332557728114568 0.35988891354999 no 2172 0.369734078393206 3099 24262820 SGTC_36 0335-0881 14.2 µM -0.333532371186266 0.359496459674808 no 2173 0.369366229126571 2999 23828853 SGTC_1493 4348-0038 111 µM -0.333926391223436 0.359337843940545 no 2174 0.369217552214706 3057 800424 SGTC_525 k781-2675 26.7 µM -0.334428571938008 0.359135722443572 no 2175 0.369028091023659 3011 3651118 YDL195W SEC31 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.334638404997227 0.359051278919013 no 2176 0.36894893527638 3161 1273210 SGTC_2183 6420625 130.508 µM -0.337859292052202 0.357755957461482 no 2177 0.367734612854369 3014 2897619 SGTC_2467 5474540 200 µM -0.338144924967251 0.357641165262891 no 2178 0.367626988579657 2997 5413519 SGTC_1614 st002383 48.6 µM -0.338182094160905 0.357626228388119 no 2179 0.367612984278922 3083 1947235 SGTC_1861 st057647 17.4 µM -0.338374871338291 0.357548762125643 no 2180 0.367540354116197 3181 688668 SGTC_1526 st051518 75 µM -0.338445875781984 0.357520230927649 no 2181 0.367513603884404 3038 673993 SGTC_443 clozapine 122 µM -0.338967880126197 0.357310502182459 no 2182 0.367316963580313 3067 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1781 st038725 66.3 µM -0.339583580320321 0.357063184102562 no 2183 0.367085072544186 2999 4270275 YIL048W NEO1 SGTC_3206 9114350 49.47 µM -0.341073095921454 0.356465115240685 no 2184 0.366524277251159 3115 17087243 SGTC_959 1222-0044 107 µM -0.34126154981208 0.356389472528971 no 2185 0.366453345564135 3147 6083612 SGTC_3035 9091303 49.47 µM -0.34155607496355 0.356271265636857 no 2186 0.366342499117666 3028 25237002 SGTC_2601 securinine 100 µM -0.342791797342695 0.355775462356588 no 2187 0.365877548635582 2987 442872 A GABA receptor antagonist. SGTC_1655 st012546 55.1 µM -0.344209514146586 0.355206938690326 no 2188 0.365344363870832 3104 720985 YLR208W SEC13 SGTC_3349 9149703 23.001 µM -0.346824897133753 0.354158980701144 no 2189 0.364361435775095 2987 4910494 SGTC_1696 st025591 34.7925 µM -0.346966316280905 0.354102346832787 no 2190 0.364308312171552 3019 2787147 SGTC_1411 3909-8223 150 µM -0.347103514555306 0.354047406373744 no 2191 0.364256776615006 3120 X1411 SGTC_1998 st075797 76.8 µM -0.348337613278284 0.353553353554236 no 2192 0.363793324615178 3138 24208315 SGTC_2748 diazoxide 86.69 µM -0.348865903337468 0.353341935922313 no 2193 0.363594992028739 3083 3019 A potassium channel activatior. SGTC_1844 rapamycin 4 nM -0.351279898469715 0.352376450203128 no 2194 0.362689186965451 2999 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_737 1950-0117 57.9 µM -0.352118220398654 0.352041382474314 no 2195 0.362374802227158 3163 5393513 SGTC_330 1488-0319 80.1 µM -0.352235351933031 0.351994575472485 no 2196 0.362330883327186 3092 6846614 SGTC_1937 st074714 47.2 µM -0.352621573008114 0.35184025333191 no 2197 0.362186081153763 2984 17250970 SGTC_3129 9127257 49.47 µM -0.352796332069507 0.351770432969298 no 2198 0.362120566889345 3027 837894 SGTC_2199 6590217 200 µM -0.353138254107656 0.35163384151905 no 2199 0.361992397690117 3065 703109 SGTC_2486 5283202 22.39 µM -0.353467119832071 0.351502483890181 no 2200 0.361869137239233 3057 1377751 SGTC_250 brefeldin a 552.239 µM -0.353869671867011 0.351341718145822 no 2201 0.361718278309248 3001 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_322 k048-0136 19.3 µM -0.354413194139367 0.351124695826812 no 2202 0.361514623985739 3126 6823282 SGTC_2425 5628681 7.85 µM -0.354470581118789 0.351101784684683 no 2203 0.361493123739693 3109 5714958 SGTC_1649 st011737 51.3 µM -0.354983603791143 0.350896989885435 no 2204 0.361300937319022 3089 1761035 SGTC_2927 9011802 47.9 µM -0.355016114458357 0.350884013329755 no 2205 0.361288759486724 3122 43912568 SGTC_300 r073-0011 5.04 µM -0.355227817450213 0.350799516837355 no 2206 0.361209463305582 3143 2735780 SGTC_194 1486-1323 56.904 µM -0.355326175207104 0.35076026205901 no 2207 0.361172624123606 3084 5178754 SGTC_906 1165-0455 526 µM -0.355501867182263 0.350690147003597 no 2208 0.361106823177084 3022 3252859 SGTC_1640 st009078 66.4 µM -0.357634956623796 0.349839281175199 no 2209 0.3603082573242 3159 690618 SGTC_1142 3253-1408 9.78 µM -0.360473846083433 0.348708048804968 no 2210 0.359246405823623 3159 256655 SGTC_1009 4106-0057 9.87 µM -0.362547178256965 0.347882721867307 no 2211 0.35847158738934 3201 2928005 SGTC_1228 0124-0032 52.5 µM -0.363458508610581 0.34752017814413 no 2212 0.358131201016346 3113 X1228 SGTC_288 1315-0019 35.1 µM -0.364553620904318 0.347084707092493 no 2213 0.357722320325441 3139 6811474 SGTC_1319 1306-0155 43.7 µM -0.365104284072962 0.346865812290124 no 2214 0.35751678155366 3057 3122360 SGTC_273 hydroxyurea 18.1 mM -0.366855546713419 0.346170005670295 no 2215 0.356863385785517 3034 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1449 4112-4002 201 µM -0.367755452629 0.345812659347938 no 2216 0.356527794169511 3091 2059539 SGTC_608 k048-0125 159 µM -0.369162389290316 0.34525424991429 no 2217 0.356003343984822 3166 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_263 alizarin 107.927 µM -0.369473125803395 0.345130964769368 no 2218 0.355887550420411 3099 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_995 3931-2021 34.6 µM -0.370610301074741 0.344679929108579 no 2219 0.355463904242932 3153 730143 SGTC_2969 9091408 28.7 µM -0.37090609240934 0.344562646097536 no 2220 0.355353738619775 3014 4286311 SGTC_1587 estradiol valerate 56.1 µM -0.371644649472474 0.344269869106667 no 2221 0.355078720464512 3204 13791 A steroid. SGTC_2476 5806916 10.51 µM -0.372373772729578 0.34398092336182 no 2222 0.354807289233148 3033 2870194 SGTC_3131 9127911 49.47 µM -0.374999677244675 0.342941054067096 no 2223 0.353830353345495 3289 45595681 SGTC_2744 captopril 92.04 µM -0.375344296872012 0.342804671298491 no 2224 0.353702213048756 3141 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2571 chrysanthemic acid 100 µM -0.375755958817758 0.342641783468714 no 2225 0.353549166057907 3092 2743 An insecticide. SGTC_793 0488-0545 106 µM -0.375894612990689 0.342586926888273 no 2226 0.35349762276921 3037 292548 SGTC_53 0973-0023 39.979 µM -0.376323201751844 0.342417382746125 no 2227 0.35333831621409 3243 674768 SGTC_848 0368-0089 85.6 µM -0.376478844149853 0.342355820493763 no 2228 0.353280470251726 3176 762535 SGTC_1328 1441-0025 69.2 µM -0.376520914681308 0.342339180781225 no 2229 0.353264834924539 3037 4562601 SGTC_658 3253-0951 102 µM -0.379285646672871 0.341246347848105 no 2230 0.352237878551151 3114 1184878 SGTC_2201 6605497 169.863 µM -0.380304796448163 0.340843837160814 no 2231 0.351859587744484 3098 670741 SGTC_2002 4023503 131 µM -0.381474730035101 0.340381998085357 no 2232 0.351425509339232 3245 4736863 YCR052W RSC6 SGTC_1434 4073-0095 163 µM -0.381722431871454 0.340284246807525 no 2233 0.351333629789591 3163 24133745 SGTC_16 erodoxin 22.806 µM -0.381985066748613 0.340180614182985 no 2234 0.351236220645388 3205 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3262 9137218 49.47 µM -0.382007940489932 0.34017158904582 no 2235 0.351227737422902 3029 17650664 SGTC_2630 antimycin a 100 µM -0.383241213050323 0.339685120726612 no 2236 0.350770461415865 3022 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_885 0865-0106 16.8 µM -0.384339669340701 0.339252055824974 no 2237 0.350363354854259 3065 2793380 SGTC_1762 st045503 25.4615 µM -0.386247164454114 0.33850053303804 no 2238 0.349656813290772 3153 4645554 SGTC_2854 9024559 71.43 µM -0.388629831585931 0.337562703017104 no 2239 0.348774997876074 3169 3163529 SGTC_3308 9128332 17.569 µM -0.390779391613135 0.336717489704501 no 2240 0.347980154627962 3232 17332805 YDL196W YDL196W SGTC_566 0958-0068 16.5 µM -0.391137243103547 0.336576861349535 no 2241 0.347847896526387 3249 6815365 SGTC_162 k030-0015 37.8 µM -0.391580032056815 0.336402885934118 no 2242 0.347684272066821 3157 1809920 YMR134W ERG29 SGTC_2173 5763948 167 µM -0.391813836509961 0.336311036370732 no 2243 0.347597885402447 3127 2867177 SGTC_400 oxethazaine 37.5 µM -0.392211517360463 0.336154830768357 no 2244 0.347450967448841 3162 4621 A local anesthetic. SGTC_2229 7354935 190 µM -0.392754461292327 0.335941612758899 no 2245 0.34725042096363 3164 318112 SGTC_2943 9068529 45.32 µM -0.393310204092383 0.335723423207592 no 2246 0.347045191262322 3111 3270634 SGTC_1098 clofazimine 15.1 µM -0.393550103336085 0.335629253742192 no 2247 0.3469566129683 3212 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_87 0100-0052 35.5 µM -0.393648592666289 0.335590595968635 no 2248 0.346920250052355 3215 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1675 st018485 24.5 µM -0.394106252252332 0.335410984111047 no 2249 0.346751297589022 3125 3323024 SGTC_1513 0337-0559 19 µM -0.394876290422724 0.335108861885325 no 2250 0.34646709428255 3101 775073 SGTC_1435 4092-0789 56.7 µM -0.395017078369057 0.335053635672463 no 2251 0.346415142041461 3193 2248285 SGTC_534 k292-0788 63.4 µM -0.395213665532487 0.334976527334323 no 2252 0.346342604133066 3260 4146317 SGTC_262 fenpropimorph 62.5 µM -0.395700189738197 0.334785725495138 no 2253 0.34616310775625 3151 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1420 4'-methoxyflavone 42 µM -0.395792146570388 0.334749667264474 no 2254 0.346129185436301 3185 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2247 cerulenin 830 nM -0.396163559783108 0.334604043749033 no 2255 0.345992185911725 3306 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_94 0334-0113 514.748 µM -0.398548127542976 0.333669696923411 no 2256 0.345113094763062 3132 6795178 SGTC_245 methotrexate 289.6 µM -0.400175813316359 0.333032511106608 no 2257 0.344513513871943 3183 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_780 0109-0199 192 µM -0.401258075987249 0.332609107142072 no 2258 0.344115063248254 3270 610414 SGTC_762 1165-0429 115 µM -0.40163925825547 0.33246003140482 no 2259 0.343974766669645 3221 5967793 SGTC_1096 rimcazole 32.2 µM -0.40333814536361 0.331795939860312 no 2260 0.343349741786561 3098 18528119 A dopamine reuptake inhibitor. SGTC_383 2324-0395 7.37 µM -0.403760465406691 0.33163093769622 no 2261 0.343194435553935 3225 3146421 SGTC_975 1335-0046 28.5 µM -0.403949898824386 0.331556935896717 no 2262 0.343124780896547 3140 16486740 SGTC_1811 st050069 61.5 µM -0.404007912094972 0.331534274439228 no 2263 0.343103450486074 3217 3877702 SGTC_2830 7992007 71.43 µM -0.4040446055211 0.331519941373038 no 2264 0.343089959247607 2972 1952075 SGTC_1982 st072467 71.9 µM -0.40427818551028 0.331428706905802 no 2265 0.343004082523042 3054 3163533 SGTC_1439 4092-1168 46 µM -0.404351029025209 0.331400256859852 no 2266 0.342977302938539 3181 2886240 SGTC_3320 9137005 35.139 µM -0.404854505828352 0.331203643613836 no 2267 0.342792230483338 3166 4908713 SGTC_1224 0823-0416 294 µM -0.405251280272397 0.331048731593038 no 2268 0.342646407199134 3247 3598164 SGTC_2499 avocadenofuran 51.48 µM -0.405728450154395 0.330862469209478 no 2269 0.342471067887949 3070 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_789 1309-1135 70.6 µM -0.407922058870789 0.330006737276658 no 2270 0.341665448676915 3133 3092424 SGTC_529 4076-0302 30.3 µM -0.40867718072895 0.329712367847309 no 2271 0.341388291077599 3128 5816522 SGTC_120 rhodamine 6G 52.259 µM -0.40958668537893 0.329357955324003 no 2272 0.341054582837229 3074 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1850 st056238 17 µM -0.409925714329081 0.329225882928855 no 2273 0.340930220809103 3161 5393177 SGTC_2580 diallyl disulphide 81.36 µM -0.410187442464048 0.32912393847633 no 2274 0.340834225955868 3106 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3232 9132874 49.47 µM -0.410405300557324 0.32903909131971 no 2275 0.340754329314897 3155 3784940 SGTC_483 fpl-64176 144 µM -0.411875852016422 0.328466599929744 no 2276 0.340215210567693 3200 3423 SGTC_1950 st077106 7.18 µM -0.412498274871267 0.328224409443178 no 2277 0.339987122444741 3192 13831864 SGTC_2860 9025725 38.96 µM -0.413694601950597 0.327759110290325 no 2278 0.339548890441263 3069 40546248 SGTC_2670 beta-carotene 100 µM -0.413830562536321 0.327706246716671 no 2279 0.339499099813847 3215 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1952 st077036 64.1 µM -0.413969084169179 0.327652390919601 no 2280 0.339448374176946 3182 2937007 SGTC_2143 5623677 140.463 µM -0.414488903476171 0.327450322457975 no 2281 0.339258045987977 3214 5375313 SGTC_1372 2752-0194 270 µM -0.416453672298122 0.326687018213912 no 2282 0.33853903042147 3185 823334 SGTC_1685 st024049 53.0905 µM -0.4167738862569 0.326562685079552 no 2283 0.338421902423534 3182 1941139 SGTC_2684 capsaicin 100 µM -0.41810299926821 0.326046821216078 no 2284 0.337935906095099 3249 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_37 0566-0070 1.56 µM -0.418132287904474 0.326035457266244 no 2285 0.3379251996074 3203 1626686 SGTC_431 k089-0097 107 µM -0.418166864648121 0.326022041746113 no 2286 0.337912560215987 3211 5499420 SGTC_2106 5357045 167.29 µM -0.418237912152755 0.32599447654794 no 2287 0.337886589656203 3215 668842 SGTC_2891 9063876 19.48 µM -0.418489164112335 0.325897002778611 no 2288 0.337794753718591 3223 6472478 SGTC_2750 bromebric acid 70.15 µM -0.41852934278303 0.325881416475211 no 2289 0.337780068774694 3272 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3283 9109332 35.8195 µM -0.418936961399518 0.325723308305254 no 2290 0.337631101789058 3138 17027281 SGTC_842 0271-0008 11.1 µM -0.420027634270872 0.325300409467834 no 2291 0.337232633139192 3266 1221709 SGTC_952 1185-0122 232 µM -0.420190480992471 0.325237286361847 no 2292 0.337173154035296 3123 678600 SGTC_3145 9085516 49.47 µM -0.421272743362849 0.324817904237792 no 2293 0.33677796556212 3219 25236195 SGTC_894 0960-0238 55.9 µM -0.42173096528575 0.324640407778121 no 2294 0.336610699928771 3269 6741907 YDL195W SEC31 SGTC_1521 st012942 49.4 µM -0.422834328444536 0.324213173383997 no 2295 0.336208069810564 3323 24207259 SGTC_851 0394-0702 453 µM -0.423021250662314 0.324140817940254 no 2296 0.336139878299178 3278 762646 SGTC_1452 4194-0072 190 µM -0.424202999887638 0.323683530211579 no 2297 0.335708886605871 3282 1343545 SGTC_2822 7994718 71.43 µM -0.424278865639757 0.323654182407478 no 2298 0.335681225241793 3170 1018011 SGTC_2694 st077685 81.9 µM -0.424545104258474 0.323551199701477 no 2299 0.335584159192493 3087 2838096 SGTC_857 0438-0306 1.35 µM -0.424632403685829 0.323517434697093 no 2300 0.335552333701735 3242 4686136 SGTC_2043 5101342 149 µM -0.4270644256301 0.322577380809201 no 2301 0.334666201549866 3174 678451 SGTC_2404 5161160 200 µM -0.42773061989221 0.322320072961248 no 2302 0.334423627155722 3143 2831543 SGTC_1820 st053765 18.6 µM -0.42903609763582 0.321816098048947 no 2303 0.333948477605239 3213 3690829 SGTC_1676 st018489 23.4 µM -0.429532901037815 0.321624394922162 no 2304 0.333767727897133 3156 3696235 SGTC_2163 5671233 125 µM -0.430011257556202 0.321439854826019 no 2305 0.333593726079071 3354 701023 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.430857147142309 0.321113635912673 no 2306 0.333286122005862 3153 91467 include heat shock SGTC_1041 0206-0046 107 µM -0.432034610016489 0.320659774914273 no 2307 0.332858129390013 3209 50494 SGTC_1012 4112-3522 18 µM -0.434055862299853 0.319881294699938 no 2308 0.332123937972968 3305 3112398 SGTC_1413 3910-0535 34.4 µM -0.434367973672779 0.319761156352867 no 2309 0.332010625238553 3283 2876951 SGTC_1711 st032263 62.8 µM -0.434794870543477 0.319596865227868 no 2310 0.331855664246998 3189 3958979 SGTC_717 1532-0246 73.2 µM -0.434816243615001 0.319588640738316 no 2311 0.331847906706637 3212 9561992 SGTC_157 1348-1695 65.819 µM -0.435945105048091 0.319154374095126 no 2312 0.331438279259787 3249 5380510 SGTC_2987 9018338 71.43 µM -0.436032530316409 0.319120752427754 no 2313 0.331406563849426 3316 5055682 SGTC_654 1124-0271 80.9 µM -0.436102437875438 0.319093868722936 no 2314 0.331381204237539 3184 5403748 SGTC_2890 9046729 58.44 µM -0.439585260414634 0.317755718716012 no 2315 0.330118759031995 3153 903329 SGTC_1109 tnp00067 928.257 nM -0.439610677210925 0.317745961936878 no 2316 0.330109553095874 3205 676295 SGTC_2035 5154463 94.595 µM -0.439948882326362 0.31761614674088 no 2317 0.329987065361498 3308 2769623 SGTC_2318 6029776 164 µM -0.441222935844738 0.31712732095103 no 2318 0.329525805172978 3335 818325 SGTC_1693 xanthone 101.9 µM -0.441854508522242 0.316885118841736 no 2319 0.329297245745253 3212 7020 An insecticide. SGTC_558 k064-0027 21.3 µM -0.441918895800508 0.316860431338569 no 2320 0.329273948255729 3261 5088526 SGTC_2127 5253358 187.912 µM -0.441956720040783 0.316845929070482 no 2321 0.329260262478598 3116 20612 SGTC_1487 3970-0795 2.82 µM -0.442543327969281 0.316621052582221 no 2322 0.329048042030087 3270 3765103 SGTC_751 0833-0568 350 µM -0.442702027977839 0.316560226484598 no 2323 0.328990637700439 3249 6954252 SGTC_291 SEC14.278 35.5 µM -0.444234118244111 0.315973266505559 no 2324 0.32843666373525 3297 1068044 SGTC_3102 9121669 49.47 µM -0.445135778780952 0.315628047427808 no 2325 0.328110816980901 3200 41905072 SGTC_132 0417-1715 25.805 µM -0.445170611419278 0.315614714268173 no 2326 0.328098231603536 3348 6769098 SGTC_2101 5377231 179.231 µM -0.445880277863278 0.315343122004901 no 2327 0.327841864593304 3288 2844213 SGTC_453 enantio-paf c16 10 µM -0.448562215349746 0.314317635270207 no 2328 0.326873747968345 3288 13871343 A lipid and platelet activating factor SGTC_612 0302-0167 22.4 µM -0.449842335319645 0.313828662676337 no 2329 0.326412064672486 3238 235821 SGTC_374 0880-0231 82.3 µM -0.451750703735578 0.313100322346762 no 2330 0.325724293270367 3244 6833587 SGTC_2502 avocadyne acetate 18.59 µM -0.452724963442827 0.312728770999527 no 2331 0.325373400803524 3120 3952079 SGTC_1838 st055369 84.5 µM -0.452944994096844 0.312644884693628 no 2332 0.325294175274798 3249 676036 SGTC_1019 4262-0212 3.4 µM -0.453304245928742 0.312507941413307 no 2333 0.325164837922355 3286 4677213 SGTC_1792 st045773 43.6 µM -0.453916238936753 0.312274715287297 no 2334 0.324944557543117 3169 2919270 SGTC_1239 0337-0584 35.4 µM -0.455163850759424 0.311799492392876 no 2335 0.324495682499294 3365 914301 YML130C ERO1 SGTC_1091 telmisartan 47.6 µM -0.456079019026949 0.311451098330996 no 2336 0.324166578456431 3325 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_52 0329-0193 875 nM -0.457168941634332 0.311036397490662 no 2337 0.323774810127204 3386 3739292 SGTC_3163 9099914 49.47 µM -0.45738798009319 0.310953085237554 no 2338 0.323696101167483 3282 16268368 SGTC_3225 9130819 49.47 µM -0.458068094063434 0.310694462619821 no 2339 0.323451760272453 3312 4547121 SGTC_1133 3473-0247 50 µM -0.458595855884763 0.310493838415474 no 2340 0.32326220655686 3209 711311 SGTC_72 0744-0168 198.391 µM -0.459682910831905 0.31008078129047 no 2341 0.322871918772173 3119 677577 SGTC_422 cantharidin 155 µM -0.45992320501105 0.309989507063886 no 2342 0.322785671713066 3154 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1417 3966-0327 90.4 µM -0.46002764156285 0.309949841149112 no 2343 0.322748190024882 3273 651118 SGTC_2897 9048598 12.99 µM -0.460411910147435 0.30980391162978 no 2344 0.322610293706319 3203 6467404 SGTC_1046 2001-0062 216 µM -0.460926962545029 0.309608362761538 no 2345 0.322425503357712 3213 739778 SGTC_2281 7943571 200 µM -0.460941642438779 0.309602790066448 no 2346 0.322420237152463 3402 1244024 SGTC_2785 7756463 72.73 µM -0.463023612765993 0.308812888522884 no 2347 0.321673720930345 3169 2201551 SGTC_1854 st056233 32.9 µM -0.463280030622863 0.308715664381592 no 2348 0.321581828833633 3299 5393174 SGTC_1815 st051655 58.2 µM -0.46444523587537 0.308274030715204 no 2349 0.321164393482789 3297 5984156 SGTC_2753 fluvastatin 17.09 µM -0.465721396204066 0.307790661316123 no 2350 0.320707467564366 3272 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2817 7995342 71.43 µM -0.467179563659259 0.30723876144161 no 2351 0.320185706824006 3140 18879975 SGTC_1579 chlormadinone acetate 49.4 µM -0.468150538623471 0.306871500305228 no 2352 0.319838470075199 3328 45114258 A steroidal progestin. SGTC_385 1494-0393 12.4 µM -0.468949385601217 0.306569490027641 no 2353 0.319552907459994 3243 3090647 SGTC_83 0170-0301 39.027 µM -0.46913547128523 0.306499157744429 no 2354 0.319486403047403 3294 3089716 SGTC_1371 2421-0008 32.7 µM -0.46915934157179 0.306490136331507 no 2355 0.31947787256198 3215 2827552 SGTC_1753 st043925 64 µM -0.469278627973976 0.30644505560163 no 2356 0.319435244806377 3307 670181 SGTC_2450 5739737 12.93 µM -0.471818129235492 0.305486022860689 no 2357 0.318528304751508 3315 2262825 SGTC_1137 ixabepilone 100 µM -0.472738581016003 0.305138746666272 no 2358 0.3181998488351 3311 154225 A novel microtubule stabilizer. SGTC_99 0109-0120 622.8 µM -0.475503920089741 0.304096470881665 no 2359 0.317213919901289 3416 759414 SGTC_2576 guaiol 23.12 µM -0.476890768348652 0.3035743560769 no 2360 0.316719953025705 3258 227829 SGTC_2993 9054257 71.4286 µM -0.478748455390304 0.302875609809895 no 2361 0.316058794900796 3246 6470217 YGL055W OLE1 SGTC_2363 9053361 176 µM -0.479343941715677 0.302651777402576 no 2362 0.315846983290167 3414 6469797 YMR079W SEC14 SGTC_1213 1315-0166 115 µM -0.479584887483415 0.302561231366526 no 2363 0.315761297219147 3293 768401 SGTC_847 0342-0274 5.54 µM -0.479685323612605 0.302523491631648 no 2364 0.315725582655737 3330 18097 SGTC_699 0375-0592 111 µM -0.480121524820268 0.302359609785975 no 2365 0.315570491749823 3378 762578 SGTC_2259 7964009 200 µM -0.480611255744693 0.302175664163278 no 2366 0.315396407107495 3359 313134 SGTC_122 0236-0016 402.397 µM -0.481743281818745 0.301750661332016 no 2367 0.314994162678616 3309 6808838 SGTC_276 colchicine 750 µM -0.483015633508278 0.301273296309373 no 2368 0.314542317933931 3385 2833 A microtubule depolymerizer. SGTC_304 1310-0298 97 µM -0.485419903294497 0.300372184464268 no 2369 0.313689258371513 3318 1550234 SGTC_2226 7298446 200 µM -0.485809552213546 0.300226260174524 no 2370 0.313551100537521 3336 3283010 SGTC_797 k781-0471 270 µM -0.486888267557515 0.29982244643102 no 2371 0.313168756848157 3249 23738129 SGTC_489 paxilline 115 µM -0.487362331911222 0.299645059728033 no 2372 0.313000791279383 3318 105008 A toxic potassium channel blocker. SGTC_2843 9000894 45.46 µM -0.488492506359933 0.299222359866785 no 2373 0.312600516154751 3268 2242070 SGTC_1214 0358-0031 63.7 µM -0.488538167051848 0.299205287865314 no 2374 0.312584349097897 3425 4301366 SGTC_2262 9014885 67.46 µM -0.490202979538452 0.298583135944964 no 2375 0.311995136317545 3275 6457424 SGTC_2978 9011784 42.97 µM -0.490699490564117 0.29839770031577 no 2376 0.311819503431465 3321 2994934 SGTC_1001 4048-4355 44.4 µM -0.491059799448863 0.298263165930759 no 2377 0.311692076676775 3279 21824233 SGTC_1478 0453-0656 35.7 µM -0.492983727063793 0.297545265747505 no 2378 0.311012042776357 3363 5258496 SGTC_211 3455-0679 143.504 µM -0.493312511816575 0.297422660972648 no 2379 0.310895894546457 3363 748649 SGTC_392 N-ethylmaleimide 8.33 µM -0.495540843290019 0.296592318609694 no 2380 0.310109199403829 3257 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_476 mead acid 10 µM -0.496192599189333 0.296349655913157 no 2381 0.309879266014561 3264 5312531 An omega 9 fatty acid. SGTC_2286 7945697 125 µM -0.496907170880776 0.296083710209828 no 2382 0.309627257244973 3301 1245733 SGTC_2032 5185112 25.99 µM -0.49790676391689 0.295711870578459 no 2383 0.309274879823203 3286 5718189 SGTC_2814 7977482 42.97 µM -0.498260704645027 0.295580259269873 no 2384 0.309150150344195 3381 6456762 SGTC_479 n-linoleoylglycine 10 µM -0.498517482084679 0.295484794563151 no 2385 0.309059675184305 3294 6433346 An anti-infammatory. SGTC_896 0964-0007 44.5 µM -0.500960610052136 0.294577198697847 no 2386 0.308199422492059 3370 6756758 SGTC_1901 st060216 58.6 µM -0.501142711595934 0.294509601463865 no 2387 0.308135344591026 3267 688792 SGTC_909 3448-9333 149 µM -0.501933641484281 0.294216086436639 no 2388 0.307857100013238 3262 3344074 SGTC_1050 3232-1156 69.3 µM -0.502028079250918 0.294181049501645 no 2389 0.307823884729024 3291 700529 SGTC_2561 acetosyringone 100 µM -0.502067756193625 0.294166329711066 no 2390 0.307809930178721 3230 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2420 aureobasidin a 50 nM -0.502426894111674 0.294033108242501 no 2391 0.307683632485802 3479 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1984 st072354 53.1 µM -0.503384589101246 0.293677989689186 no 2392 0.307346952227833 3230 5762938 SGTC_3213 9129884 49.47 µM -0.503837137188904 0.293510251472574 no 2393 0.30718791416885 3335 17190742 SGTC_1177 0983-0204 23.6 µM -0.50429961147224 0.293338879939153 no 2394 0.307025425227056 3392 766818 SGTC_730 1436-0052 41.2 µM -0.50500107945423 0.293079036958097 no 2395 0.306779038904203 3377 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_299 1273-0059 1.44 µM -0.505007375854243 0.293076705082349 no 2396 0.306776827727374 3350 2848077 SGTC_2721 ifenprodil 61.44 µM -0.505591057617795 0.292860575555946 no 2397 0.306571880254611 3408 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2394 5221648 200 µM -0.50567256613805 0.292830399932553 no 2398 0.306543265077085 3391 788586 SGTC_2117 5521686 200 µM -0.505793274500331 0.292785714617151 no 2399 0.306500890186644 3259 803312 SGTC_2464 5717415 7.67 µM -0.506079808042773 0.292679654764187 no 2400 0.306400312424775 3274 5285744 SGTC_2729 fluphenazine 10.66 µM -0.506579964002047 0.292494565748241 no 2401 0.306224784797544 3264 3372 An atypical antipsychotic. SGTC_1076 itraconazole 331 nM -0.507221314445944 0.292257305573209 no 2402 0.305999770634539 3370 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2663 amphotericin b 100 µM -0.507562534679589 0.292131111592694 no 2403 0.305880085274946 3349 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_310 1273-0058 1.06 µM -0.509321174249598 0.291481113834631 no 2404 0.305263559192436 3390 2734232 SGTC_1605 st000082 49.1 µM -0.509346133574472 0.291471893660057 no 2405 0.305254813173868 3393 1114022 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.509695682165139 0.291342781906129 no 2406 0.305132339234641 3362 3256 An antibiotic and ribosome inhibitor. SGTC_3122 9126309 49.47 µM -0.512991005678252 0.29012691163306 no 2407 0.303978806160446 3406 17591206 SGTC_2985 9022375 71.43 µM -0.515021613044291 0.289378867722602 no 2408 0.303268958545809 3461 4939335 SGTC_3039 9090270 49.47 µM -0.515371825430246 0.289249946646642 no 2409 0.303146608346273 3429 17173750 SGTC_1705 st027868 56.3335 µM -0.515710658665782 0.289125240193886 no 2410 0.303028254583043 3361 292948 SGTC_2655 perillic acid 100 µM -0.516553301775134 0.288815217851687 no 2411 0.302734010733103 3313 5702197 An apoptosis inducer. SGTC_1128 3448-9350 235 µM -0.516613662466641 0.288793016162185 no 2412 0.302712938202822 3324 619386 SGTC_114 0364-0001 490.298 µM -0.518155631889706 0.288226126189054 no 2413 0.302174843978913 3372 4003655 SGTC_2091 4-phenylthiadiazole 200 µM -0.519294334338492 0.287807830592754 no 2414 0.301777751851168 3287 270010 SGTC_1362 1611-0397 101 µM -0.519578005346362 0.287703670362024 no 2415 0.301678865656434 3334 27816 SGTC_1044 1222-0021 1.78 µM -0.520800222549153 0.287255092252109 no 2416 0.301252974023174 3353 4306703 SGTC_1090 efavirenz 20.7 µM -0.521694354772714 0.286927137665125 no 2417 0.300941577921729 3372 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2352 9027995 87.8 µM -0.522410564772311 0.286664570362809 no 2418 0.300692250872502 3331 2997347 SGTC_2815 7968870 71.43 µM -0.523288084925153 0.286343021102594 no 2419 0.300386895682472 3357 2977326 YHR190W ERG9 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.524307830318357 0.285969571554112 no 2420 0.300032225765436 3390 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3326 9140064 16.379 µM -0.525164051115033 0.285656186628829 no 2421 0.299734576502345 3298 1868434 SGTC_3180 9109287 49.47 µM -0.525980241776804 0.285357605323743 no 2422 0.299450967542346 3403 18891271 SGTC_716 1683-5115 658 µM -0.52603701137619 0.285336843229646 no 2423 0.299431245835698 3439 723597 SGTC_1361 1608-0041 5.61 µM -0.526764216080179 0.285070949538576 no 2424 0.299178667697444 3361 X1361 SGTC_80 0159-0065 512.242 µM -0.527181001751871 0.284918610120378 no 2425 0.299033950205692 3395 1548079 SGTC_1253 0550-0034 176 µM -0.529333512935749 0.284132464076748 no 2426 0.298287055742193 3401 5969915 SGTC_556 4058-0063 51.5 µM -0.529628191524442 0.284024921535838 no 2427 0.298184872089564 3383 6615692 SGTC_386 1509-0011 3.07 µM -0.529741189945935 0.283983688085216 no 2428 0.298145692639349 3394 3107280 SGTC_507 nimesulide 162 µM -0.529744542357217 0.283982464824399 no 2429 0.298144530308214 3479 4495 A COX2 inhibitor. SGTC_2566 crystal violet carbinol 226 nM -0.533574500826211 0.282586601339578 no 2430 0.29681797702184 3407 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3018 9082602 49.47 µM -0.534226121775219 0.282349440821372 no 2431 0.296592549271667 3442 17332089 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.534588370641623 0.282217640062266 no 2432 0.296467263492351 3308 688667 SGTC_465 cgp-37157 41 µM -0.534615220620333 0.282207872135119 no 2433 0.296457978243881 3340 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2223 6903751 107.57 µM -0.534721841447148 0.282169085462105 no 2434 0.296421107989428 3398 5598863 SGTC_3347 9188721 44.724 µM -0.536504795560275 0.281520860466315 no 2435 0.295804861246136 3405 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1846 st056244 14.8 µM -0.536983529820037 0.281346930444662 no 2436 0.295639495448727 3369 5393182 SGTC_1440 4100-1550 40 µM -0.539160698300727 0.280556593427605 no 2437 0.294887988108957 3404 742806 SGTC_1460 k062-0059 9.15 µM -0.540176466335939 0.280188225952687 no 2438 0.294537670345837 3332 1373085 SGTC_2202 7226349 200 µM -0.541604723497216 0.279670666356815 no 2439 0.294045418582139 3325 844334 SGTC_1945 st075991 56.6 µM -0.54293184472272 0.279190171776109 no 2440 0.293588364670629 3354 1084980 SGTC_3304 9125678 46.087 µM -0.543237111903169 0.279079704207719 no 2441 0.293483278731491 3361 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1784 st039334 36.3 µM -0.543404304296214 0.27901921101331 no 2442 0.293425731388032 3514 3496984 SGTC_2525 harmine 47.85 µM -0.543745714701963 0.278895702440683 no 2443 0.293308234733933 3340 5280953 A monoamine oxidase inhibitor SGTC_1557 sumaresinolic acid 42.3 µM -0.543756131078601 0.278891934632172 no 2444 0.293304650272703 3370 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_827 3253-0474 693 µM -0.54498652219536 0.278447052267079 no 2445 0.292881393623524 3459 5402065 SGTC_492 tmb-8 126 µM -0.545100570414993 0.278405832457219 no 2446 0.292842175202091 3359 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2938 9059746 27.26 µM -0.545212938213596 0.278365222900923 no 2447 0.292803537021188 3390 6471769 SGTC_280 3448-3607 3.04 µM -0.545647285771795 0.278208277488495 no 2448 0.29265420689058 3443 626179 SGTC_652 0437-0092 114 µM -0.545923187959298 0.278108606508113 no 2449 0.292559369180865 3423 3091274 SGTC_3147 9097027 49.47 µM -0.548388420870666 0.277218803293255 no 2450 0.29171261272021 3365 25236841 SGTC_3200 9114385 49.47 µM -0.548786545995433 0.277075234401468 no 2451 0.291575972179338 3453 17018030 YLR208W SEC13 SGTC_3240 9133527 49.47 µM -0.550392576005862 0.276496449669384 no 2452 0.291025069796524 3397 17617455 SGTC_328 k915-0120 63.5 µM -0.551102348093285 0.276240849414672 no 2453 0.290781757939307 3439 6624543 SGTC_151 3013-0144 2.285 µM -0.551276840627574 0.276178029629532 no 2454 0.290721955979164 3448 906558 YHR107C CDC12 SGTC_235 0330-0087 5 mM -0.551708740013756 0.276022569892234 no 2455 0.290573960463867 3422 46494818 YHR062C RPP1 SGTC_2207 7258803 200 µM -0.552245615672614 0.275829384466843 no 2456 0.290390042726895 3431 3666799 SGTC_2449 5812982 45.77 µM -0.552560568259996 0.275716085149506 no 2457 0.290282174648175 3431 776185 SGTC_393 acivicin 6.25 µM -0.553005832429645 0.275555947298279 no 2458 0.290129708197928 3336 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1910 st062352 60.4 µM -0.553249061555829 0.275468490033468 no 2459 0.290046438027747 3371 2245730 SGTC_2770 toltrazuril 17.5 µM -0.554936789427166 0.274862014468601 no 2460 0.289468948477163 3468 68591 Kills coccidiodes. SGTC_3106 9121286 49.47 µM -0.557753738952866 0.273851227558091 no 2461 0.288506278103618 3519 15943471 SGTC_523 1934-0222 13.7 µM -0.558601628063057 0.273547345508093 no 2462 0.288216814333163 3366 1361595 SGTC_1230 0170-0365 3.77 µM -0.558841868774822 0.273461273987808 no 2463 0.28813482264687 3540 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_130 0136-0219 337.655 µM -0.559226367789721 0.273323546662844 no 2464 0.288003619991321 3419 234244 SGTC_1344 1488-0097 29.1 µM -0.559333619054778 0.27328513545043 no 2465 0.287967027657351 3452 747966 SGTC_3238 9133470 49.47 µM -0.560123710013943 0.273002252901652 no 2466 0.287697529531272 3492 3534688 SGTC_3159 9100096 49.47 µM -0.560270010027236 0.272949887877971 no 2467 0.287647640029062 3415 25236875 SGTC_2635 hydroquinidine 100 µM -0.560475540405003 0.272876331000682 no 2468 0.287577559395392 3426 442912 An experimental heart treatment. SGTC_2880 9042983 58.44 µM -0.560519778104659 0.272860500140058 no 2469 0.287562476520115 3477 6464714 SGTC_701 4424-0219 185 µM -0.560732656603153 0.272784326016309 no 2470 0.287489900674528 3506 2911779 SGTC_1438 4092-1045 4 µM -0.560852595813388 0.272741412922323 no 2471 0.287449014077242 3427 1351342 SGTC_1849 st056239 19.2 µM -0.561433948971257 0.272533457840229 no 2472 0.287250873059476 3350 5393181 SGTC_3146 9095609 49.47 µM -0.56212923172746 0.272284852569466 no 2473 0.287013986640445 3406 17173999 SGTC_1456 k015-0012 13 µM -0.562728152654817 0.272070792805825 no 2474 0.286810005401975 3531 2989616 SGTC_808 0711-0032 135 µM -0.56289640592242 0.272010672622488 no 2475 0.286752713858782 3455 4252555 SGTC_663 1486-0733 13.9 µM -0.563147105635776 0.271921104969072 no 2476 0.286667358726634 3402 722445 YPR165W RHO1 SGTC_1774 st048371 48.465 µM -0.564174937737107 0.271554044155128 no 2477 0.28631754119855 3358 4242727 SGTC_3097 9117246 49.47 µM -0.564543107712825 0.271422622837833 no 2478 0.286192285700983 3505 16423892 SGTC_231 b-estradiol 524 µM -0.565683312443676 0.27101581846506 no 2479 0.28580454063643 3359 450 A steroid. SGTC_2725 haloperidol 53.21 µM -0.566072542801139 0.270877017800055 no 2480 0.285672233779961 3424 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_880 0833-0487 87.2 µM -0.566585821445168 0.270694035413349 no 2481 0.285497805099256 3447 76075 SGTC_347 4534-1311 26.2 µM -0.56690761486673 0.270579348454094 no 2482 0.285388475153608 3455 2862016 SGTC_2019 4016004 108 µM -0.569277994611493 0.269735295317122 no 2483 0.284583748996539 3416 45595336 SGTC_1238 0333-0287 48.8 µM -0.569646137425783 0.26960432413296 no 2484 0.284458864549526 3428 7226 SGTC_2238 6671620 73.2395 µM -0.571361892759085 0.268994344359909 no 2485 0.283877177458617 3449 729941 SGTC_324 1315-0088 19.6 µM -0.571800977487641 0.268838353781786 no 2486 0.283728407502992 3447 6787421 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.571861310170073 0.268816923359754 no 2487 0.283707968602083 3394 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1494 4358-1428 177 µM -0.572315241052216 0.268655712721992 no 2488 0.28355421306679 3510 1564571 SGTC_2214 7179297 48.276 µM -0.57478418346922 0.267779735227852 no 2489 0.282718632454877 3478 769744 SGTC_259 usnic acid 108.925 µM -0.577264203371959 0.266901278561045 no 2490 0.281880495745986 3561 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_336 4111-0029 111 µM -0.578481720729747 0.266470550829326 no 2491 0.281469467491727 3438 3131175 SGTC_1709 st033179 39.1045 µM -0.579625581668158 0.266066201528828 no 2492 0.281083568956698 3450 573381 SGTC_1167 k781-0610 148 µM -0.580160092657528 0.265877361071986 no 2493 0.28090333137157 3462 4525169 SGTC_722 3534-0461 190 µM -0.580918576485419 0.26560950858653 no 2494 0.280647665866624 3457 658262 SGTC_2614 arthonioic acid 13.39 µM -0.581126250828716 0.265536193928786 no 2495 0.280577683791572 3462 6710684 SGTC_1024 4507-0395 26 µM -0.582158443657275 0.265171954325374 no 2496 0.280229980917361 3544 4201836 SGTC_1914 st062367 72.6 µM -0.582470225384648 0.265061982887449 no 2497 0.280124995671649 3432 978205 SGTC_1893 st059353 36.1 µM -0.58431871235329 0.264410462042659 no 2498 0.279502952468736 3460 3112488 SGTC_3024 9090631 49.47 µM -0.585040703216523 0.264156209463975 no 2499 0.279260174150542 3472 25236383 SGTC_2964 9083345 53.42 µM -0.58583254821732 0.263877500674988 no 2500 0.278994024407314 3418 17741579 SGTC_3160 9100216 49.47 µM -0.588506312005636 0.262937514568443 no 2501 0.278096249192765 3462 17191039 SGTC_928 2764-0428 58.7 µM -0.588593216427682 0.26290699127283 no 2502 0.278067092777342 3500 662578 SGTC_1511 0906-3109 28.5 µM -0.588856089175533 0.262814673943963 no 2503 0.27797890810428 3518 2882180 SGTC_2835 9006588 71.43 µM -0.58986387448684 0.262460907142088 no 2504 0.277640957654579 3542 2345538 SGTC_2322 7413319 38.22 µM -0.590117840460262 0.262371794952335 no 2505 0.277555824449005 3521 1840400 SGTC_3278 9139605 49.47 µM -0.590225589534998 0.262333992380351 no 2506 0.277519709196553 3560 7958859 SGTC_1944 st076371 56.9 µM -0.592170721715492 0.261652044291426 no 2507 0.276868136517061 3391 24208455 SGTC_3186 9110464 49.47 µM -0.592270832198958 0.261616970973001 no 2508 0.276834622185573 3527 17018021 SGTC_2059 5238311 157 µM -0.593129638308576 0.26131619076163 no 2509 0.276547198368066 3450 703021 SGTC_2072 5231554 129 µM -0.593379226692619 0.261228810589222 no 2510 0.27646369398257 3570 789545 SGTC_2389 9091542 195.52 µM -0.594104721180271 0.260974902337241 no 2511 0.276221036682278 3450 3626624 YOL127W RPL25 SGTC_2009 4012297 12.05 µM -0.598248081275035 0.259527246769967 no 2512 0.274837206801978 3491 45595307 SGTC_2153 5569715 200 µM -0.599672385505086 0.259030566202837 no 2513 0.274362297688418 3524 2054701 SGTC_3010 9080089 71.4286 µM -0.600272130507049 0.258821571477698 no 2514 0.274162444573729 3523 17027233 SGTC_2309 7664088 163.95 µM -0.600734287526931 0.258660581946904 no 2515 0.274008488994799 3539 704922 SGTC_1155 4088-0394 48.2 µM -0.600970250653587 0.258578405651443 no 2516 0.273929900501698 3439 2326248 SGTC_2581 avocatin a 64 µM -0.601172124833683 0.258508111872403 no 2517 0.273862674317875 3463 6710728 A skin care supplement. SGTC_2109 5483026 200 µM -0.603097553622126 0.257838163934566 no 2518 0.273221896899633 3509 759335 SGTC_269 exalamide 29 µM -0.605431560722547 0.257027261982187 no 2519 0.272446142984532 3478 3316 A derivative of salicylamide. SGTC_2894 9048625 32.47 µM -0.605778067144264 0.256906988762167 no 2520 0.272331067969556 3603 4092861 SGTC_3078 9116413 49.47 µM -0.606906752432255 0.256515422510461 no 2521 0.271956398341177 3467 17177322 SGTC_3057 9095946 49.47 µM -0.607472818346694 0.256319158668555 no 2522 0.271768588067883 3519 24540043 SGTC_768 0384-0033 77.3 µM -0.608189131735999 0.256070913928379 no 2523 0.271531021000648 3462 3965305 YMR134W ERG29 SGTC_1380 2291-0730 164 µM -0.614742288949217 0.253805694018399 no 2524 0.269362463631086 3498 2999191 SGTC_320 4092-0846 5.34 µM -0.615038062946973 0.253703702959709 no 2525 0.269264791903051 3492 1359356 SGTC_1481 3346-2004 36 µM -0.615054407465403 0.253698067545085 no 2526 0.269259395065691 3544 2770522 SGTC_725 1497-0963 19 µM -0.615771670098822 0.253450827836984 no 2527 0.269022613768669 3568 3549977 SGTC_272 doxorubicin 8.13 µM -0.615867246458399 0.25341789232484 no 2528 0.268991070185927 3551 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1317 1273-0028 910 nM -0.616478506599681 0.253207305934867 no 2529 0.268789376612592 3510 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2522 biochanin a 4.94 µM -0.616585891449013 0.253170320082548 no 2530 0.268753951371376 3534 5280373 A possible chelator. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.61814732918283 0.252632845614981 no 2531 0.26823911303666 3588 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1365 1672-3266 55.4 µM -0.618163939249138 0.252627131369042 no 2532 0.268233639022549 3551 6415873 SGTC_3237 9133362 49.47 µM -0.618706807097411 0.252440409787232 no 2533 0.268054762415724 3520 43845137 SGTC_3210 9128157 49.47 µM -0.618932007730757 0.252362972472524 no 2534 0.267980575748678 3452 17590849 SGTC_2371 9071574 200 µM -0.620498940085425 0.251824515184275 no 2535 0.26746467580338 3530 45596039 SGTC_3296 9122258 64.045 µM -0.620910839210156 0.25168307179041 no 2536 0.267329144496743 3538 4730474 SGTC_2408 sulbentine 18.36 µM -0.620943478715953 0.25167186539768 no 2537 0.267318406274085 3422 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_428 3448-4153 16.5 µM -0.621115741976984 0.251612725186968 no 2538 0.267261736188998 3496 3834874 SGTC_216 k038-0035 28.382 µM -0.621761454028771 0.251391109217344 no 2539 0.267049367862833 3510 4444231 YPR107C YTH1 SGTC_1231 0242-0792 125 µM -0.621858906791581 0.251357671246145 no 2540 0.267017324012332 3536 3707635 SGTC_2892 9047358 58.44 µM -0.623492398720112 0.250797538014425 no 2541 0.266480497913225 3513 6466771 SGTC_1560 lithocholic acid 53.1 µM -0.623944454451314 0.25064264248941 no 2542 0.266332032118209 3510 9903 A bile acid which acts as a detergent. SGTC_408 cantharidin 100 µM -0.624075766855995 0.250597658191508 no 2543 0.266288913865251 3488 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1680 diphenhydramine 100 µM -0.624313549642279 0.250516210728335 no 2544 0.266210843575314 3479 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1229 0139-0193 12.2 µM -0.624703955315002 0.250382515950263 no 2545 0.266082688346159 3589 3090752 SGTC_2305 7443522 69.23 µM -0.625690225504206 0.250044935354215 no 2546 0.265759072845794 3526 5415886 SGTC_308 4092-1169 104 µM -0.625954771765595 0.249954427541368 no 2547 0.265672303734088 3530 2268590 YDL196W YDL196W SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.627604217383658 0.249390503807983 no 2548 0.265131622628219 3539 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_571 k831-0106 44.2 µM -0.627937771459552 0.249276548322278 no 2549 0.265022353025032 3545 4783639 SGTC_2883 9059145 45.46 µM -0.629075567346738 0.24888803987895 no 2550 0.264649792556967 3543 16476510 SGTC_609 0986-0026 86.3 µM -0.629569963169171 0.248719325436062 no 2551 0.264487990398391 3551 2848610 SGTC_2140 5586273 200 µM -0.630015294872026 0.248567406462188 no 2552 0.264342288682765 3557 854421 SGTC_1995 st072814 61.1 µM -0.630937263023649 0.248253046499402 no 2553 0.264040773022333 3488 5769371 SGTC_568 1193-0097 7.48 µM -0.630983468398169 0.248237297609262 no 2554 0.26402566687003 3495 3646150 SGTC_227 fluconazole 33.516 µM -0.633551249866139 0.247362919159504 no 2555 0.263186862206961 3538 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2604 4'-hydroxychalcone 11.32 µM -0.633581132219586 0.247352753349145 no 2556 0.263177108703713 3594 5282362 SGTC_735 3076-0345 636 µM -0.635527958883676 0.246690935233094 no 2557 0.262542068943744 3610 2888990 SGTC_1416 3966-0321 25.3 µM -0.635902999489855 0.246563550280559 no 2558 0.262419823766049 3563 582530 YLR208W SEC13 SGTC_1392 3455-1037 33.9 µM -0.636510982873985 0.246357119702945 no 2559 0.262221712396969 3601 981132 SGTC_1742 st038235 28.8875 µM -0.637402563650394 0.246054565989733 no 2560 0.261931329460616 3545 564103 YBR002C RER2 SGTC_2853 9015042 58.44 µM -0.637634096134932 0.245976029152888 no 2561 0.261855947587187 3523 6457456 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.637955891963838 0.245866896934576 no 2562 0.261751196440071 3602 5357218 A potent inhibitor of glutathione S-transferases. SGTC_771 0250-0039 27.3 µM -0.638821095836836 0.245573604958631 no 2563 0.261469661465281 3546 3005115 SGTC_1575 cyproterone acetate 48 µM -0.638869998452303 0.245557033271075 no 2564 0.26145375333159 3510 9880 An androgen receptor antagonist and liver toxin. SGTC_1790 st045711 43.5 µM -0.638969664666286 0.245523261122233 no 2565 0.261421333220798 3607 585119 SGTC_620 0109-0052 432 µM -0.64108535157714 0.244806944314512 no 2566 0.260733615426961 3602 493037 SGTC_572 0960-0087 17.7 µM -0.64185184785642 0.244547706394266 no 2567 0.26048469075852 3538 6796365 SGTC_2148 5546263 113.568 µM -0.642518759904466 0.244322269371792 no 2568 0.260268206324002 3558 792097 SGTC_2225 6654152 15.4 µM -0.643007172454103 0.244157241814042 no 2569 0.260109722935578 3552 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2040 5100729 123 µM -0.643638591988651 0.243943983370853 no 2570 0.25990490943623 3578 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1123 mangostin 811.285 nM -0.643682942639205 0.243929007963151 no 2571 0.259890526546998 3532 5281650 An antioxidant. SGTC_3316 9136639 10.545 µM -0.644372982988228 0.243696073361272 no 2572 0.259666799779474 3574 4903665 SGTC_463 ikarugamyin 104 µM -0.644432887777776 0.243675857169681 no 2573 0.259647381975882 3622 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2971 9092186 9.93 µM -0.645011713716192 0.243480566251531 no 2574 0.259459797394579 3496 25236400 SGTC_1653 st012112 65 µM -0.645543224742661 0.243301313472364 no 2575 0.259287608190269 3599 720429 SGTC_3002 9075603 71.4286 µM -0.646101757138958 0.243113024584557 no 2576 0.259106728749355 3572 20105405 SGTC_1206 3978-0017 132 µM -0.649071280718361 0.242113282118595 no 2577 0.258146151974044 3645 3873677 SGTC_352 k048-0007 5.11 µM -0.650167831085143 0.241744673444154 no 2578 0.257791908961024 3575 6811911 SGTC_929 2805-0021 398 µM -0.651102359858209 0.241430769371936 no 2579 0.257490206637281 3601 3098024 SGTC_2241 6772625 37.8075 µM -0.653404173018877 0.240658545723022 no 2580 0.256747874624078 3562 2285411 SGTC_1728 st035614 33.7865 µM -0.654728425889114 0.240214888803529 no 2581 0.256321310045435 3563 15945546 SGTC_1249 0481-0015 10.2 µM -0.656033215903183 0.239778188721519 no 2582 0.255901376356981 3566 4227577 SGTC_1976 st070609 63.5 µM -0.656043409352977 0.239774778782528 no 2583 0.255898097110483 3558 682556 SGTC_542 3381-0244 89.3 µM -0.656499360037116 0.239622280052538 no 2584 0.255751439593583 3618 1112843 SGTC_279 1273-0055 2.93 µM -0.656542511872126 0.239607850093984 no 2585 0.255737561986497 3641 2847562 SGTC_625 k213-0058 121 µM -0.657617510970785 0.239248523907678 no 2586 0.255391969785252 3667 3655420 SGTC_1531 st059297 52.4 µM -0.657866262151566 0.239165419000528 no 2587 0.255312035697375 3622 7566702 SGTC_930 2810-3379 265 µM -0.658368023669112 0.238997834266137 no 2588 0.255150838681797 3657 1015764 SGTC_2776 terbinafine 19.92 µM -0.658521507862015 0.238946584476612 no 2589 0.255101540643193 3614 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1163 k060-0048 49.9 µM -0.65884190141549 0.238839621477697 no 2590 0.254998648553607 3622 6809982 SGTC_1178 0988-0033 191 µM -0.659356913051657 0.238667740365007 no 2591 0.254833301777617 3609 5392207 SGTC_2421 5690543 90.72 µM -0.662318605487037 0.2376806137197 no 2592 0.253883527701676 3628 3397993 SGTC_1000 4048-0884 8.67 µM -0.662452826897379 0.237635931088773 no 2593 0.253840528790227 3610 13040088 SGTC_627 1391-0720 175 µM -0.663425617821215 0.237312224444283 no 2594 0.253529001663182 3577 997839 SGTC_1629 st005085 44.9 µM -0.663710133139136 0.237217594701212 no 2595 0.253437926294055 3610 24207091 SGTC_1591 genipin 88.4 µM -0.663736854164217 0.237208708358001 no 2596 0.253429373587915 3607 442424 A DNA cross-linking agent. SGTC_1267 0828-0272 9.49 µM -0.664376588415528 0.236996012961219 no 2597 0.253224656564796 3654 745334 SGTC_1258 0671-0043 57.1 µM -0.664655129936923 0.236903437742902 no 2598 0.25313554956085 3604 4298767 SGTC_530 4358-1714 28 µM -0.66499206740207 0.236791480799005 no 2599 0.253027783410472 3611 1564641 SGTC_3087 9117406 49.47 µM -0.665194418522267 0.236724257937722 no 2600 0.252963074988529 3610 42546093 SGTC_908 3448-7491 47.7 µM -0.665254168838203 0.236704410353086 no 2601 0.252943969526492 3646 1203031 SGTC_2946 9065502 71.43 µM -0.665505501952538 0.2366209337008 no 2602 0.252863612823539 3462 16489101 SGTC_1780 st038448 24.544 µM -0.665575272508625 0.236597763293977 no 2603 0.252841308031358 3651 728868 YDL195W SEC31 SGTC_2246 7293507 91.5585 µM -0.665651283231567 0.236572521983927 no 2604 0.252817009513123 3642 887656 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.667975319542684 0.235801481770008 no 2605 0.252074673421256 3631 688664 SGTC_3053 9095903 49.47 µM -0.670879267809956 0.234839995854411 no 2606 0.251148722360021 3678 17174018 SGTC_1279 0874-0590 65.2 µM -0.671347372711976 0.234685211210283 no 2607 0.250999631288442 3637 3523074 SGTC_632 0781-2353 4.65 µM -0.672428535398256 0.234327927173071 no 2608 0.250655460837669 3661 6811515 YHR007C ERG11 SGTC_1905 st060207 84.5 µM -0.672599401819921 0.234271489739381 no 2609 0.250601091190673 3574 1948547 SGTC_2689 tacrolimus 100 µM -0.674446111612217 0.233661999098781 no 2610 0.250013867523699 3635 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2472 5377652 49.4 µM -0.674789885613006 0.233548636592155 no 2611 0.249904633650525 3630 1610903 SGTC_29 0299-0004 12.984 µM -0.675785711452209 0.233220426453582 no 2612 0.249588353927666 3540 16871 A napthoquinone isolated from Swertia calycina. SGTC_1732 st034308 51.822 µM -0.67632766257449 0.233041914645896 no 2613 0.249416316689353 3562 830119 SGTC_331 k048-0133 24.5 µM -0.677257637687469 0.232735769555199 no 2614 0.24912125184983 3618 6813582 SGTC_603 3794-0023 45.9 µM -0.678270150057423 0.232402707737227 no 2615 0.24880021063438 3624 3802260 SGTC_2751 anetholtrithion 17.25 µM -0.680962569038478 0.231518338601409 no 2616 0.247947587682232 3617 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_141 0443-0274 32.331 µM -0.681499427940763 0.231342223106062 no 2617 0.247777764306292 3731 1627241 SGTC_3179 9107801 49.47 µM -0.681853829813339 0.23122600323213 no 2618 0.247665691193251 3651 4818259 SGTC_1710 st031758 61.5 µM -0.682811221084693 0.230912206478204 no 2619 0.247363069112549 3668 5394341 SGTC_1347 1493-0251 600 nM -0.68400577035354 0.230521011911169 no 2620 0.24698576102524 3674 3986378 SGTC_1081 sertraline 6 µM -0.685227153926087 0.230121412832335 no 2621 0.246600295733458 3647 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2466 5983409 37.09 µM -0.687296852150875 0.229445156938803 no 2622 0.245947841044571 3641 2879657 SGTC_2414 st077232 92.9 µM -0.687496140095419 0.229380100172027 no 2623 0.245885066149667 3626 729801 SGTC_1490 4089-0339 670 nM -0.687760109425041 0.229293944341217 no 2624 0.245801930120905 3623 742542 SGTC_1384 3089-0840 101 µM -0.689134227850147 0.228845744812015 no 2625 0.24536940113978 3633 1069836 SGTC_3144 9087057 49.47 µM -0.689297282626759 0.228792593497808 no 2626 0.245318103821028 3587 17249618 SGTC_1119 parthenolide 318.541 nM -0.689699454949921 0.228661526155618 no 2627 0.245191604350283 3749 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_815 1582-0027 36.9 µM -0.690184556903297 0.22850348829026 no 2628 0.24503906683649 3683 3128206 SGTC_867 0518-0118 155 µM -0.691822906753434 0.227970195930043 no 2629 0.244524274723545 3688 6848158 SGTC_843 0310-0051 143 µM -0.692436000748651 0.227770810452324 no 2630 0.244331782043195 3680 2065037 SGTC_2856 9022925 19.48 µM -0.692581238892906 0.227723591658999 no 2631 0.244286193695929 3651 4944862 SGTC_3148 9097893 49.47 µM -0.692675859233894 0.227692832330495 no 2632 0.244256496079518 3619 17174100 SGTC_2832 7992762 51.95 µM -0.692696301730952 0.227686187158807 no 2633 0.244250080236603 3590 2985177 SGTC_1130 3454-2858 15.9 µM -0.693855942177738 0.227309405656022 no 2634 0.243886277851028 3672 715628 YIL048W NEO1 SGTC_164 4100-3994 89.624 µM -0.698019105653746 0.225959640997287 no 2635 0.242582622910876 3686 4615967 SGTC_3036 9090181 49.47 µM -0.698721190305999 0.225732461209378 no 2636 0.242363144250512 3687 25236586 SGTC_1038 k292-0204 154 µM -0.699752077130709 0.225399122234262 no 2637 0.242041073831299 3634 4454212 SGTC_2356 9061756 188.97 µM -0.700343226076593 0.225208099031456 no 2638 0.241856491406378 3658 20104043 SGTC_825 1988-2224 89.6 µM -0.700946274790359 0.225013325073346 no 2639 0.241668272081401 3687 1180859 SGTC_319 1348-1596 45.5 µM -0.701562480877738 0.224814400166287 no 2640 0.241476028336313 3734 5380505 SGTC_2346 9031566 143.75 µM -0.701718165336742 0.224764157574387 no 2641 0.241427471103758 3663 4771086 SGTC_1909 st060837 51.5 µM -0.701765090713513 0.224749015034564 no 2642 0.241412836345204 3669 678937 SGTC_2800 7887935 81.82 µM -0.702752387760829 0.224430554314137 no 2643 0.241105036803722 3661 2961002 SGTC_624 k048-0052 28 µM -0.703891101570423 0.224063571107517 no 2644 0.240750296717979 3659 6835531 SGTC_773 4358-1457 44.6 µM -0.703936851843116 0.224048833895356 no 2645 0.240736050210668 3677 1186886 SGTC_2652 actinonin 100 µM -0.70436568396776 0.223910724004647 no 2646 0.240602535390606 3667 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3253 9135987 49.47 µM -0.706094692205706 0.223354369753363 no 2647 0.240064626151526 3678 4182430 SGTC_326 k292-0812 17.5 µM -0.707696178626726 0.222839751511434 no 2648 0.23956697550138 3662 3579357 SGTC_482 fipronil 114 µM -0.708136365238382 0.222698421335838 no 2649 0.239430289341636 3722 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_754 3474-0146 171 µM -0.7093612181086 0.222305428304228 no 2650 0.239050173892286 3646 24762078 SGTC_823 0417-1665 178 µM -0.709505863419107 0.222259045111109 no 2651 0.239005307092151 3719 3429856 SGTC_1143 3454-2408 5.08 µM -0.709593113110692 0.222231069554546 no 2652 0.238978245776138 3646 X1143 SGTC_1180 1193-0155 285 µM -0.709671433769036 0.222205958695787 no 2653 0.238953955311079 3675 2921347 SGTC_2250 alverine citrate 130 µM -0.710770561041744 0.221853731717261 no 2654 0.23861321308209 3637 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3107 9121808 49.47 µM -0.711007718216003 0.221777774036142 no 2655 0.23853972649617 3636 662681 SGTC_1959 st077091 55.8 µM -0.71180413153454 0.22152280422442 no 2656 0.238293036973121 3710 821356 YKL052C ASK1 SGTC_1294 1000-1494 117 µM -0.71334180345869 0.221030996614316 no 2657 0.237817137750177 3688 712797 YDL207W GLE1 SGTC_271 rotenone 740 µM -0.715274131126232 0.220413849610009 no 2658 0.237219835029254 3720 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2485 5633444 17.78 µM -0.715912273260592 0.220210256859099 no 2659 0.237022759769959 3703 5724239 SGTC_203 k066-0004 30.888 µM -0.716869552058254 0.219905049120373 no 2660 0.236727295430183 3763 6795412 SGTC_2656 pseudo-anisatin 100 µM -0.718673929076286 0.219330422872851 no 2661 0.236170925211237 3739 6708809 A neurotoxin. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.71934094360015 0.219118222470924 no 2662 0.23596543725365 3724 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_563 tetrahydrosecaminediol 614 µM -0.720127864573336 0.218868027525874 no 2663 0.235723136321172 3749 334274 A psychoactive constituent of the cannabis plant. SGTC_2539 epi(13)torulosol 80 µM -0.720558183207301 0.218731280855841 no 2664 0.235590694909637 3710 6708597 SGTC_455 paf C-16 10 µM -0.721594119372851 0.218402282772279 no 2665 0.235272027854954 3684 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3310 9130229 44.1445 µM -0.722198296069034 0.218210536806701 no 2666 0.235086285394941 3768 7761258 SGTC_2036 5160441 105 µM -0.722215209691209 0.218205170371219 no 2667 0.235081086794138 3710 134534 YIL048W NEO1 SGTC_1967 st070177 51.4 µM -0.723898079320021 0.217671601743153 no 2668 0.234564154615944 3746 5729214 SGTC_3203 9113543 49.47 µM -0.724753570970479 0.217400649460518 no 2669 0.234301611889745 3772 17018012 SGTC_452 diindolylmethane 8 µM -0.725571925631988 0.217141641577831 no 2670 0.234050618460128 3676 3071 Inhibits expression of several cancer promoting factors. SGTC_236 1509-0011 5.31 µM -0.726634365045125 0.216805647388941 no 2671 0.233724985313064 3784 3107280 SGTC_999 SEC7.066 22.7 µM -0.726648659469067 0.216801128858377 no 2672 0.233720605845965 3722 740511 YDR170C SEC7 SGTC_904 1141-0088 396 µM -0.727575545545703 0.216508252330407 no 2673 0.233436727408777 3676 1378119 SGTC_215 1287-0124 461.5 µM -0.72799770848933 0.216374933624315 no 2674 0.233307494517174 3730 5560863 SGTC_685 1278-0033 54.9 µM -0.731475690485695 0.215278399465275 no 2675 0.232244323843063 3756 3590572 SGTC_2296 7971656 126.45 µM -0.733305395488413 0.214702829082516 no 2676 0.231686092493985 3780 666570 SGTC_1225 1216-0074 20.6 µM -0.733460709269318 0.214654013229863 no 2677 0.231638741700417 3736 4241466 SGTC_1290 0986-0249 10.2 µM -0.73499981774898 0.214170612992084 no 2678 0.231169802557944 3680 53329 SGTC_1737 st035557 69.7 µM -0.735351484392073 0.214060251171377 no 2679 0.231062730340555 3649 5716916 SGTC_1008 4106-0037 6 µM -0.736051163687283 0.213840772707846 no 2680 0.230849780782994 3696 2905394 SGTC_414 piperonyl butoxide 100 µM -0.737280644053254 0.213455421531204 no 2681 0.230475850263485 3718 5794 A potent inhibitor of cytochrome P450. SGTC_1047 2043-3044 82 µM -0.738852791905961 0.212963259578513 no 2682 0.229998195508193 3738 669592 SGTC_2801 7907800 81.82 µM -0.740058955826599 0.212586118435581 no 2683 0.229632110988962 3794 6620925 SGTC_3059 1327-0034 3 µM -0.740178101188019 0.212548885461281 no 2684 0.229595966733752 3697 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1042 0350-0096 82 µM -0.740267416681086 0.212520976831117 no 2685 0.229568873837363 3745 3122515 SGTC_3014 9081533 49.47 µM -0.740758668245687 0.212367512525125 no 2686 0.229419889970002 3743 21367265 SGTC_2197 6588183 93.1375 µM -0.741348906287481 0.212183211054694 no 2687 0.229240957760071 3702 884136 SGTC_2232 chlorophetanol 41.5365 µM -0.741422465993345 0.212160248635662 no 2688 0.22921866342753 3806 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_844 0330-0132 15.3 µM -0.741970323787729 0.211989274897133 no 2689 0.229052658006597 3745 2828079 SGTC_1988 st071872 53.4 µM -0.742770313430584 0.211739761445577 no 2690 0.228810375751229 3746 16414116 SGTC_3191 9110352 49.47 µM -0.743184016318547 0.21161079667879 no 2691 0.228685139497397 3709 17122424 SGTC_1261 0712-0010 12.7 µM -0.744902455216291 0.211075595290245 no 2692 0.228165345391169 3743 2840123 SGTC_1276 0871-0068 94.2 µM -0.745455586601773 0.210903493516584 no 2693 0.227998175411918 3741 3414906 SGTC_2981 9013952 38.96 µM -0.745466357046778 0.210900143207968 no 2694 0.227994921001117 3665 2996344 SGTC_824 1304-0008 100 µM -0.745846694780229 0.210781853456208 no 2695 0.227880014442187 3760 768245 SGTC_2607 solasodine 47.35 µM -0.746459530863024 0.210591335723379 no 2696 0.227694934708615 3785 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1332 1480-0653 17.5 µM -0.74649562419368 0.210580118224572 no 2697 0.227684036971301 3707 5749438 SGTC_775 4577-0580 57.3 µM -0.746787228319339 0.210489503014081 no 2698 0.227596003076905 3802 2006902 SGTC_1972 st070201 17.4 µM -0.74681772579232 0.210480027327167 no 2699 0.227586797142464 3712 2829099 SGTC_3092 9117248 49.47 µM -0.749193975893757 0.209742486963609 no 2700 0.226870149760501 3816 17141857 SGTC_1612 st002233 45.4 µM -0.749917454227483 0.209518235907725 no 2701 0.226652210768286 3765 1035021 SGTC_2369 9071472 200 µM -0.750138700366773 0.209449686102759 no 2702 0.226585586677095 3823 17296037 SGTC_255 tunicamycin 200.472 nM -0.750788655643322 0.20924838352615 no 2703 0.226389928890136 3727 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1051 3253-3903 78 µM -0.753780018347207 0.20832337524944 no 2704 0.225490662094774 3763 5509239 SGTC_1338 1486-1223 76 µM -0.754395876184464 0.208133235624607 no 2705 0.225305773528876 3789 3444526 SGTC_602 3130-1533 38.1 µM -0.75457286375148 0.208078611528281 no 2706 0.225252655434996 3775 720941 SGTC_1862 st057513 3.81 µM -0.756344336355007 0.207532344055265 no 2707 0.224721386149587 3750 5393163 SGTC_1500 4488-1866 171 µM -0.756696310368332 0.207423907149868 no 2708 0.224615912905326 3846 2900003 SGTC_2434 5670830 169.91 µM -0.756761727479816 0.207403756998118 no 2709 0.224596312976589 3794 1549830 SGTC_874 0599-0792 117 µM -0.757469498398946 0.20718581936299 no 2710 0.224384316445236 3770 765305 SGTC_2285 7945142 200 µM -0.758108988615337 0.206989023327836 no 2711 0.224192869540021 3804 2970608 SGTC_527 4476-4215 268 µM -0.758565002942208 0.206848757551633 no 2712 0.224056407266614 3769 4418754 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.760194465596081 0.20634800987408 no 2713 0.223569176332132 3752 61125 An anti-inflammatory. SGTC_2940 9060638 45.86 µM -0.762899769427733 0.205518235313451 no 2714 0.222761586868512 3792 4027022 SGTC_2438 5259590 200 µM -0.763337417716519 0.205384185639383 no 2715 0.222631096154962 3807 1201127 SGTC_3091 9116372 49.47 µM -0.76476226371618 0.20494812170133 no 2716 0.222206561190541 3826 17169793 SGTC_1166 k206-0078 225 µM -0.76532425973742 0.204776278313257 no 2717 0.222039240774109 3799 5404595 SGTC_1819 st053448 58.6 µM -0.765638355952759 0.204680273414225 no 2718 0.221945757736302 3724 2857616 SGTC_610 4215-0184 155 µM -0.76592543536018 0.204592549746588 no 2719 0.22186033525033 3814 5605015 SGTC_2020 4017018 200 µM -0.766706435188867 0.20435401065773 no 2720 0.221628038342062 3864 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_902 1120-0002 2.07 µM -0.769276157396442 0.203570315435601 no 2721 0.220864694083769 3765 3280475 SGTC_3301 9125354 19.7965 µM -0.769542260315151 0.203489263843432 no 2722 0.220785733455914 3754 41905162 SGTC_2911 7942208 15.64 µM -0.769826366309936 0.203402749992103 no 2723 0.220701448626952 3790 1243384 SGTC_3138 9097216 49.47 µM -0.771819852243539 0.202796325886138 no 2724 0.220110566011558 3781 25237486 SGTC_1701 st028638 40.4 µM -0.773629826309552 0.202246663317898 no 2725 0.219574864368947 3753 3490878 SGTC_2227 7312221 64.1025 µM -0.774473298529575 0.201990817899056 no 2726 0.219325476220579 3815 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2929 9013348 24.6 µM -0.775611275962926 0.201645949113462 no 2727 0.218989270257966 3828 2995952 SGTC_583 1488-1091 88.9 µM -0.775974973297919 0.201535803545025 no 2728 0.218881881446219 3892 4303273 SGTC_1373 2887-0003 58.5 µM -0.77800940818545 0.200920340979927 no 2729 0.218281733423702 3800 776948 SGTC_2511 berberine 10.47 µM -0.77812424432359 0.200885634107922 no 2730 0.218247885634012 3781 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_559 1550-0661 158 µM -0.778550517811834 0.200756833136653 no 2731 0.218122268576141 3855 5830875 SGTC_2065 5221596 34.26 µM -0.779615610601393 0.200435225986154 no 2732 0.217808582277239 3787 788581 SGTC_3267 9137951 49.47 µM -0.780942043816757 0.200035139472565 no 2733 0.217418291228415 3797 16643986 SGTC_3214 9129694 49.47 µM -0.785511865808479 0.198660443937786 no 2734 0.216076758011327 3772 17158655 SGTC_1523 st012844 44.7 µM -0.786353033873301 0.198408025728112 no 2735 0.215830345248639 3930 4274103 SGTC_2914 7968218 45.32 µM -0.78713144767571 0.198174611343975 no 2736 0.215602460948881 3799 2977111 SGTC_704 1310-0270 142 µM -0.788349009352847 0.197809847132394 no 2737 0.215246293984471 3802 5718033 SGTC_9 0092-0002 10.449 µM -0.788865014779901 0.197655381691332 no 2738 0.215095452692755 3791 759368 SGTC_532 1548-0774 215 µM -0.789681230682986 0.197411197614335 no 2739 0.214856977728707 3946 5932993 SGTC_588 3970-1144 52.9 µM -0.791627217081804 0.19682976097888 no 2740 0.214289036109589 3753 1888707 SGTC_31 0508-1974 57.237 µM -0.792860924180755 0.196461682249651 no 2741 0.213929427973865 3763 6810525 SGTC_687 k029-0044 34.9 µM -0.792983326961484 0.19642518592007 no 2742 0.213893768466194 3846 5829338 SGTC_2012 4023501 200 µM -0.794472638182813 0.195981453397949 no 2743 0.21346016588548 3841 3477460 SGTC_2297 7971671 152.32 µM -0.796064953489059 0.19550770461687 no 2744 0.212997141554865 3805 909016 SGTC_1510 1123-0200 71.5 µM -0.799098195388839 0.194607174924388 no 2745 0.212116737985571 3869 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2290 7904846 200 µM -0.799193565025501 0.19457890192001 no 2746 0.212089091333132 3899 2962154 SGTC_966 1300-0360 30.2 µM -0.802278620214782 0.193665664228798 no 2747 0.211195903404419 3829 70588 SGTC_578 3460-0051 92 µM -0.802713550812227 0.193537126654407 no 2748 0.211070159422213 3905 2876744 SGTC_497 capsazepine 133 µM -0.80314246609988 0.193410417793288 no 2749 0.210946197529017 3827 2733484 A calcium channel blocker. SGTC_3193 9111931 49.47 µM -0.8054040707027 0.192743138779034 no 2750 0.210293271732565 3860 17087244 SGTC_2680 butyl paraben 22.24 µM -0.806238033422471 0.192497436221514 no 2751 0.210052806293789 3883 7184 An antifungal and steroid mimetic. SGTC_2873 9040596 71.43 µM -0.807544491684459 0.192112911913368 no 2752 0.209676426085323 3799 6463863 SGTC_800 3448-7362 155 µM -0.807854741685454 0.192021666449817 no 2753 0.209587103840654 3921 15991913 SGTC_2521 angolensin 13.4 µM -0.807966537016315 0.191988793606178 no 2754 0.209554922993634 3916 821428 A flavenoid. SGTC_2282 7944268 200 µM -0.80978058223282 0.191455864396181 no 2755 0.209033147316392 3839 2970414 SGTC_3070 9117005 49.47 µM -0.810326042034902 0.191295796933709 no 2756 0.208876405904287 3876 8779016 SGTC_592 k241-0073 46.5 µM -0.810441093393617 0.191262045109235 no 2757 0.208843353995162 3831 4230158 SGTC_2821 7996764 71.43 µM -0.810612638293517 0.191211726943429 no 2758 0.208794078366777 3878 2987135 SGTC_3052 9092717 49.47 µM -0.812547785095508 0.190644665035722 no 2759 0.208238689425845 3828 25237534 SGTC_1949 st076024 69.1 µM -0.813406444881574 0.190393380340992 no 2760 0.207992532720423 3806 2921930 SGTC_10 0279-0212 42.575 µM -0.81496804831293 0.189936902563769 no 2761 0.207545299855636 3843 39851 YBR002C RER2 SGTC_2310 7668677 200 µM -0.815804252682694 0.189692745563265 no 2762 0.207306050290082 3831 2197143 SGTC_736 0958-0254 92.6 µM -0.818161806656623 0.189005421207736 no 2763 0.206632400306919 3946 6812352 SGTC_1990 st072050 59.8 µM -0.818232252241631 0.188984907042922 no 2764 0.206612291078297 3859 17233948 SGTC_1235 benzylparaben 21.5 µM -0.819541731588015 0.188603828782311 no 2765 0.206238701286469 3868 7180 SGTC_1956 st077085 54 µM -0.820757585444005 0.188250421436856 no 2766 0.205892181269312 3895 24208685 SGTC_1969 st069479 40.1 µM -0.821675268069861 0.187983953083937 no 2767 0.205630869332742 3868 3895485 SGTC_3327 9140648 26.9345 µM -0.821739054446156 0.187965440034155 no 2768 0.205612713356662 3878 8029710 SGTC_2877 9040724 71.43 µM -0.822813910430765 0.187653648339067 no 2769 0.205306912495923 3809 6463895 SGTC_1436 4092-1007 8.32 µM -0.823615992069996 0.187421190688677 no 2770 0.205078893161055 3844 2881121 SGTC_311 1315-0136 58 µM -0.82452013459414 0.187159367467193 no 2771 0.204822040048048 3940 6759207 SGTC_1172 0370-0043 85 µM -0.82461746642697 0.187131195432254 no 2772 0.204794400968121 3918 376585 SGTC_548 1436-0017 110 µM -0.824912987969972 0.187045674809876 no 2773 0.204710496038859 3934 9677137 SGTC_1751 st044839 27.194 µM -0.825880661483708 0.186765810178854 no 2774 0.204435895832063 3816 5291326 SGTC_3227 9130768 49.47 µM -0.828045663817234 0.186140600696774 no 2775 0.203822319861956 3900 17720899 SGTC_765 1319-0117 244 µM -0.832094845907297 0.184974764534764 no 2776 0.202677705420447 3827 3487746 YGL099W LSG1 SGTC_2448 5185112 27.17 µM -0.832133108323514 0.184963769744209 no 2777 0.202666907832771 3905 5718189 SGTC_2997 9067075 71.4286 µM -0.832162493901153 0.184955326008696 no 2778 0.202658615506986 3905 27209819 SGTC_503 tyrphostin 8 294 µM -0.8323921189517 0.184889353141903 no 2779 0.202593824522046 3831 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1899 st063254 59.6 µM -0.832612881785422 0.184825940241903 no 2780 0.202531545774649 3812 3093813 SGTC_426 0988-0037 14.6 µM -0.832647789176234 0.184815914525323 no 2781 0.202521699202328 3848 5383008 SGTC_56 0957-0365 83.25 µM -0.833602996038226 0.184541701716395 no 2782 0.202252368386752 3890 6752360 SGTC_1148 3909-7663 27.7 µM -0.833897934268915 0.184457084463984 no 2783 0.202169250701882 3934 4084526 SGTC_2357 9067248 200 µM -0.834623714314368 0.18424896225223 no 2784 0.201964802858192 3902 9150235 SGTC_1430 4049-0248 69.1 µM -0.835442936227184 0.18401422061072 no 2785 0.201734181751259 3892 22774488 SGTC_870 0573-2213 57.6 µM -0.835819767998864 0.18390630496385 no 2786 0.201628151923807 3868 3916321 SGTC_1794 st048918 76.9 µM -0.836979108241976 0.183574544745233 no 2787 0.201302155697261 3782 672303 SGTC_631 k072-0230 41.5 µM -0.837401431109141 0.183453784328077 no 2788 0.20118348079981 3902 5773147 SGTC_1810 st050138 53 µM -0.837441883518685 0.183442219829779 no 2789 0.201172115666798 3834 3444541 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.838616083265628 0.183106738728174 no 2790 0.200842391222188 3927 5282309 SGTC_2049 5262831 67.185 µM -0.83940314407028 0.182882081650167 no 2791 0.200621560068294 3940 763417 SGTC_3284 9108171 64.8615 µM -0.839693676215601 0.182799196219762 no 2792 0.200540080285582 3872 8687505 SGTC_2958 9077254 16.72 µM -0.840777036365258 0.182490333004426 no 2793 0.200236427023461 3943 16457351 SGTC_1207 2099-0101 141 µM -0.84170556537887 0.182225871335756 no 2794 0.199976391143516 3919 5837381 SGTC_2834 9001755 58.44 µM -0.84233744423424 0.182046037972764 no 2795 0.199799548724867 3838 2989575 SGTC_2267 7931562 200 µM -0.843993554714622 0.181575233997126 no 2796 0.199336503627467 3796 934880 SGTC_253 dyclonine 31.25 µM -0.844049448555621 0.181559357635494 no 2797 0.199320887104562 3978 3180 An oral anasthetic. SGTC_1825 st052143 62.6 µM -0.84635721972004 0.180904605581645 no 2798 0.198676748105905 3897 674173 SGTC_1621 st003705 32.4 µM -0.84710002299226 0.180694175468907 no 2799 0.198469686157552 3932 24207032 SGTC_1343 1487-0095 224 µM -0.847226301724701 0.180658417002608 no 2800 0.198434497972275 3872 4560101 YGL055W OLE1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.847697403254306 0.180525053902781 no 2801 0.198303256450806 3882 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2147 5545932 89.7195 µM -0.848578509985823 0.180275789127674 no 2802 0.198057934550311 3923 797404 SGTC_1147 3809-1045 12.3 µM -0.849963271550543 0.179884477295837 no 2803 0.197672753235905 3873 325925 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.851827210948598 0.179358600375424 no 2804 0.197155000619334 3884 7104 SGTC_2145 5634607 200 µM -0.851895950394945 0.179339225278406 no 2805 0.197135922337573 3871 308662 SGTC_1619 st003326 88.7 µM -0.853119783520767 0.178994492491427 no 2806 0.196796440741437 3876 2849032 SGTC_812 4251-0442 148 µM -0.853561050975293 0.178870297367277 no 2807 0.196674123538426 3870 5723007 SGTC_3236 9132701 49.47 µM -0.854767614660937 0.178530985913967 no 2808 0.196339905106914 3908 24282524 SGTC_1647 st011722 22.4 µM -0.856699892053287 0.177988433419898 no 2809 0.195805381508939 3871 2854783 SGTC_3228 9131799 49.47 µM -0.857607940729455 0.177733827393857 no 2810 0.195554494412044 3918 17015818 SGTC_3000 9075062 71.4286 µM -0.85866647935229 0.177437315987949 no 2811 0.195262274600878 3881 17057871 SGTC_3223 9129970 49.47 µM -0.860844842158443 0.176828109454296 no 2812 0.194661751935845 3933 17248386 SGTC_190 3970-0790 3.722 µM -0.861039425807031 0.176773756088758 no 2813 0.194608164591468 3832 2832352 SGTC_2764 methyldopa 94.69 µM -0.861754420170789 0.176574126272438 no 2814 0.194411335894554 3892 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_246 cycloheximide 667 µM -0.861859038508484 0.176544928298009 no 2815 0.194382545986926 3779 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2018 5133068 143 µM -0.864340068364728 0.175853391712289 no 2816 0.193700552573965 3905 785362 SGTC_2553 4-methylesculetin 85.09 µM -0.864825019530303 0.17571842215823 no 2817 0.193567418303278 3955 5319502 SGTC_3305 9127027 53.8275 µM -0.868284801812082 0.174757415326344 no 2818 0.192619220079044 3854 41905295 SGTC_961 1252-1571 372 µM -0.8692807118604 0.17448140583277 no 2819 0.192346805073838 3917 6813498 SGTC_395 anisomycin 6.25 µM -0.87045243649737 0.174157025280607 no 2820 0.19202660068226 3945 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_145 3737-0113 38.366 µM -0.870840076030522 0.174049795483427 no 2821 0.191920739897135 3909 6849351 SGTC_3189 9110682 49.47 µM -0.872093486386572 0.173703361383592 no 2822 0.191578689640396 4032 17122418 SGTC_2141 5621638 7.665 µM -0.873452385503992 0.173328266878281 no 2823 0.191208274147989 3971 2856238 SGTC_1364 1653-0028 37.6 µM -0.873743651761374 0.173247936332665 no 2824 0.19112893651828 3936 5718652 SGTC_2373 9071805 200 µM -0.874944026259086 0.172917126109872 no 2825 0.190802181161412 3892 10149009 SGTC_579 4491-1009 110 µM -0.876272983063745 0.172551349805421 no 2826 0.190440824345843 4068 1271041 SGTC_1947 st076332 61.6 µM -0.877379446641849 0.172247188260763 no 2827 0.190140286529103 3865 24208416 SGTC_416 estradiol valerate 100 µM -0.877852559179872 0.17211723636635 no 2828 0.190011868624625 3962 13791 A steroid. SGTC_1610 st001799 48.1 µM -0.881643508424227 0.171078220137258 no 2829 0.188984809522166 3853 621897 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.883673689087035 0.170523445007087 no 2830 0.188436193714628 3974 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2791 5663188 71.43 µM -0.884720312117444 0.170237891219453 no 2831 0.1881537488428 3980 54690634 SGTC_2052 5265182 7.135 µM -0.885262604767471 0.170090056201509 no 2832 0.188007506910066 3964 1239884 SGTC_2658 polymyxin b sulfate 77.05 µM -0.886967335431493 0.169625863670852 no 2833 0.187548243474282 3968 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2497 7-hydroxyflavone 100 µM -0.887034247955393 0.169607660201733 no 2834 0.187530231038117 3987 5281894 SGTC_2221 6807166 181.081 µM -0.887703645888176 0.169425620308429 no 2835 0.187350092116594 3880 674925 SGTC_2037 5169046 200 µM -0.888935050849617 0.169091072635009 no 2836 0.187018993302542 4028 5718022 SGTC_1200 1643-0193 18.4 µM -0.890129835688683 0.16876687967978 no 2837 0.186698087102818 3938 5403974 SGTC_2125 5246583 200 µM -0.890646151046507 0.168626906335192 no 2838 0.186559515966624 3923 835267 SGTC_327 1273-0057 3.96 µM -0.890803631090931 0.168584228274127 no 2839 0.186517263412739 3841 3108138 SGTC_2416 tofa 880 nM -0.89121848507771 0.168471833533519 no 2840 0.186405984727602 3991 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_244 nsc-207895 1.295 µM -0.891327977340575 0.168442177268449 no 2841 0.186376621845348 3767 42640 SGTC_782 0083-0095 30.5 µM -0.891591189330425 0.168370899349558 no 2842 0.186306047187618 3929 3591729 An indicator and reagent. SGTC_3047 9092122 49.47 µM -0.89241880375665 0.168146907416382 no 2843 0.186084248006893 3954 17173831 SGTC_107 0358-0022 2.6945 µM -0.892959697870742 0.168000619322032 no 2844 0.185939377838317 3992 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1018 4259-0013 28.1 µM -0.893309897271108 0.167905949467939 no 2845 0.185845619623097 4031 6801262 SGTC_2319 6033012 152.6 µM -0.893353659762829 0.167894121511596 no 2846 0.185833905236259 3917 847246 SGTC_1092 toremifene 6.32 µM -0.894723082726832 0.167524270204869 no 2847 0.185467568160194 3954 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2520 obtusaquinone 4.71 µM -0.89491592690332 0.167472229386981 no 2848 0.185416016058457 3989 5967872 SGTC_3295 9122362 53.5725 µM -0.895732015564326 0.167252115492364 no 2849 0.185197953506588 4026 4730473 SGTC_1476 4112-3294 3.34 µM -0.897049747650393 0.166897093113135 no 2850 0.184846185963822 3999 704369 SGTC_2741 miltefosine 3.04 µM -0.898973080913656 0.166379783324772 no 2851 0.18433349963095 3935 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.899644965454468 0.166199314015476 no 2852 0.184154609895117 4014 23847180 SGTC_3161 9100388 49.47 µM -0.901763168380388 0.165631189199376 no 2853 0.183591344531784 4030 25236368 SGTC_2128 5255449 168.493 µM -0.902999363114776 0.165300209498964 no 2854 0.18326311647617 3966 736008 SGTC_1077 5-fluorocytosine 377 nM -0.903798371010059 0.165086510401373 no 2855 0.183051162844424 3997 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1186 1319-0216 26 µM -0.903930223636852 0.165051262884163 no 2856 0.183016200872027 4034 4565136 SGTC_877 0771-0151 33.1 µM -0.906416004752888 0.1643876630958 no 2857 0.18235785235088 4000 6166523 SGTC_963 1269-2853 151 µM -0.907262918865893 0.164161967968349 no 2858 0.182133889130232 3959 3668223 SGTC_1101 ebselen 5.29 µM -0.907438046481786 0.164115323093594 no 2859 0.182087598759718 4038 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.907793648740513 0.164020635627928 no 2860 0.181993627305469 4037 5377381 SGTC_3023 9089636 49.47 µM -0.908128024314168 0.163931632604777 no 2861 0.181905292883723 4050 17249241 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.908361485431206 0.163869509251646 no 2862 0.181843633665722 3959 2724278 An inhibitor of dopamine biosynthesis. SGTC_3030 9087619 49.47 µM -0.908705540126074 0.163777985107127 no 2863 0.1817527895035 4005 25236973 SGTC_3037 9091026 49.47 µM -0.90877345507447 0.163759922548178 no 2864 0.181734860604272 3948 25236398 YIL048W NEO1 SGTC_1219 1469-0211 33.1 µM -0.908793811530378 0.163754508827234 no 2865 0.181729486909422 3994 6822282 SGTC_1045 1348-1485 165 µM -0.909448608692499 0.163580430017234 no 2866 0.181556686662057 3989 6810614 SGTC_2799 7812892 81.82 µM -0.916133519852041 0.161810114779268 no 2867 0.179798434345704 4024 20205235 SGTC_1039 k821-0043 94 µM -0.917027015328651 0.161574446381467 no 2868 0.179564241936265 4007 15992768 SGTC_2676 harmalol 100 µM -0.918179898834412 0.161270692590199 no 2869 0.179262345242503 3937 5459187 A monoamine oxidase inhibitor SGTC_2926 9010726 65.15 µM -0.918196762812682 0.161266252151591 no 2870 0.179257931572935 4035 2994293 SGTC_1602 st001878 87.6 µM -0.921085554130559 0.160506784169684 no 2871 0.178502880836554 4010 595405 YLR310C CDC25 SGTC_1856 st057054 55.7 µM -0.921490468150891 0.160400518622786 no 2872 0.178397207731431 4033 1266018 SGTC_941 3237-0776 460 µM -0.921722772243473 0.160339573545326 no 2873 0.178336599583245 4041 760008 SGTC_1509 1326-1131 80 µM -0.922685354305449 0.160087201020602 no 2874 0.178085600166455 3894 768313 SGTC_1374 2889-5571 141 µM -0.927279967172537 0.158886152824667 no 2875 0.17689059634913 4051 2853281 SGTC_71 0417-1750 47.813 µM -0.929578343617368 0.158287570719349 no 2876 0.176294722282446 4018 6811472 SGTC_156 3474-0145 5.642 µM -0.930116711468346 0.158147574018374 no 2877 0.176155329556289 3848 2265471 SGTC_1583 clindamycin 39.6 µM -0.931514592097733 0.157784449938682 no 2878 0.175793719984233 3992 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1529 apigenin 74 µM -0.93286930975399 0.15743306113147 no 2879 0.175443724980292 4030 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2824 7998404 51.95 µM -0.936311746450195 0.156542472216763 no 2880 0.174556350999108 3975 837851 SGTC_1540 guanosine 70.6 µM -0.936610816276623 0.156465257109807 no 2881 0.17447939308673 3900 6802 Guanosine is a purine nucleoside SGTC_2885 9057732 51.95 µM -0.937391923307402 0.156263705919369 no 2882 0.174278496985744 4092 6471414 SGTC_1333 1482-0047 286 µM -0.937680487059799 0.156189290304736 no 2883 0.174204317292353 4016 3811116 SGTC_195 4234-0266 16.654 µM -0.938119377704256 0.156076152746186 no 2884 0.174091532263781 4016 2303354 SGTC_849 0386-0493 241 µM -0.939636292637788 0.155685537278959 no 2885 0.173702076781961 3983 726119 SGTC_284 0988-0104 32.6 µM -0.939867451388375 0.155626069055144 no 2886 0.173642777370421 4001 4666532 SGTC_733 4069-0007 56.1 µM -0.94064402881123 0.155426395388552 no 2887 0.173443655434463 4017 5717425 YNL287W SEC21 SGTC_752 1896-0090 130 µM -0.942785220345473 0.154876727955048 no 2888 0.172895386472595 3994 772567 SGTC_2179 6298986 200 µM -0.943710918174157 0.154639489171861 no 2889 0.172658696567934 3996 738374 SGTC_181 1447-1644 8.07 µM -0.945342282576567 0.154221986264956 no 2890 0.172242079204952 4046 534600 SGTC_1399 3562-5772 25 µM -0.945620691992087 0.154150809561805 no 2891 0.172171043218999 3971 23847490 SGTC_2167 5876490 200 µM -0.946578060828564 0.153906219476868 no 2892 0.171926913877236 4177 686534 SGTC_517 1365-0151 113 µM -0.948603912471583 0.153389498915504 no 2893 0.171411050186196 4096 768657 SGTC_1174 0739-0097 51.1 µM -0.948918375050713 0.153309394186451 no 2894 0.171331064100063 4057 728447 SGTC_834 0312-0008 75.7 µM -0.950639297075626 0.152871505499881 no 2895 0.17089375641893 4026 6385573 YIL048W NEO1 SGTC_2193 5925765 200 µM -0.952814071023985 0.152319321583989 no 2896 0.170342141818947 4025 877370 SGTC_2138 5575593 77.673 µM -0.954373708251161 0.151924139590973 no 2897 0.169947254944156 4004 762213 SGTC_91 0417-1751 58.384 µM -0.955760145122561 0.151573415576822 no 2898 0.169596714049225 4157 6795624 SGTC_2175 5807670 165.306 µM -0.957253186945739 0.151196326303083 no 2899 0.169219738711626 4034 241186 SGTC_306 1672-3436 11.6 µM -0.960342598917154 0.150418034024916 no 2900 0.168441408565725 4092 6797378 SGTC_1501 4491-0275 38.4 µM -0.960539189599756 0.15036859890635 no 2901 0.16839195857231 3968 5104718 SGTC_703 3875-0075 71.8 µM -0.960901606514642 0.150277493141149 no 2902 0.168300821480848 4090 2850814 SGTC_103 0844-0104 51.839 µM -0.963445437894049 0.149639050407998 no 2903 0.167662016544432 3982 5375804 SGTC_646 4092-0839 27.3 µM -0.964190427655393 0.149452418363789 no 2904 0.167475231317727 4090 877796 SGTC_458 nppb 133 µM -0.964812934249282 0.149296589546261 no 2905 0.167319258157867 4063 4549 A chloride channel blocker. SGTC_170 4197-0004 226 µM -0.965767595209483 0.149057825085759 no 2906 0.167080243452549 4087 218692 SGTC_2273 7815444 169.05 µM -0.966109796759868 0.148972301267711 no 2907 0.166994621425417 4014 2824616 SGTC_2922 7999257 32.47 µM -0.968254175082025 0.148437119673747 no 2908 0.166458722312955 4007 2988377 SGTC_193 1273-0060 1.558 µM -0.968277768828455 0.148431238442798 no 2909 0.16645283220889 3860 2847393 YHR072W ERG7 SGTC_2287 7945887 168.79 µM -0.968856558240089 0.148287011973014 no 2910 0.16630838140505 4072 1245853 SGTC_2089 5281248 129.67 µM -0.969508172616413 0.148124750730945 no 2911 0.166145852286533 4032 2737878 SGTC_2698 st077697 67.5 µM -0.969960808880648 0.148012107823999 no 2912 0.166033013759862 4032 3154499 SGTC_1933 st074711 15.9 µM -0.970077906889548 0.147982976190523 no 2913 0.166003830245988 4019 17250958 SGTC_2735 sertaconazole 140 nM -0.971268000353707 0.147687122548894 no 2914 0.165707419663475 4173 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1907 st060210 83.7 µM -0.972053771204704 0.147491999556131 no 2915 0.165511899357945 4109 688793 SGTC_889 0919-1524 82.7 µM -0.972190437504888 0.147458080155752 no 2916 0.165477908453813 4082 3905452 SGTC_2248 tofa 1.1 µM -0.973062472911014 0.147241771546442 no 2917 0.165261126856907 4009 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1252 0493-0875 34.8 µM -0.97472172476298 0.146830781319822 no 2918 0.164849156812496 4046 3960963 SGTC_2545 solidagenone 89.61 µM -0.977102850753062 0.146242331470689 no 2919 0.164259118294967 3864 6708572 An anti ulcer agent SGTC_350 k064-0020 19.8 µM -0.977312545771575 0.146190585334441 no 2920 0.164207221958143 4091 2790705 SGTC_2384 9036245 200 µM -0.980858861792388 0.14531732863382 no 2921 0.16333117329541 4013 6462766 SGTC_2108 5365811 200 µM -0.984173690139458 0.144504253643411 no 2922 0.162515059781671 4091 780283 SGTC_496 calpeptin 138 µM -0.984838819651934 0.144341477838109 no 2923 0.16235162451972 4095 73364 A calpain inhibitor. SGTC_750 4073-0104 132 µM -0.985238714122342 0.144243671979209 no 2924 0.16225341418329 3844 22330957 SGTC_2714 st079313 56.9 µM -0.988935900911639 0.143341533183821 no 2925 0.161347252038245 4043 2939799 SGTC_970 1315-0089 19.5 µM -0.989438548344836 0.143219178628027 no 2926 0.161224311011851 4015 6811083 YLR033W RSC58 SGTC_878 0828-0289 13.7 µM -0.99183555656164 0.142636668805879 no 2927 0.160638874794602 4031 745350 YLR208W SEC13 SGTC_645 0845-0943 5.41 µM -0.993667008893771 0.142192678816524 no 2928 0.160192504678194 4081 1885106 SGTC_3338 9144300 39.5675 µM -0.993993653931551 0.142113590249424 no 2929 0.160112978506368 4099 4901274 SGTC_2203 7227154 166.4 µM -0.997365743863911 0.141298866972504 no 2930 0.159293506350681 4066 896304 SGTC_2144 5628481 200 µM -0.999462361694527 0.140793907046326 no 2931 0.158785381633177 4061 2818399 SGTC_1674 st016616 23.6 µM -0.999514515765313 0.140781361626439 no 2932 0.158772755419104 4036 625830 SGTC_2879 9041815 71.43 µM -1.00105927291527 0.14041012138257 no 2933 0.158399076649387 4100 4942971 SGTC_1348 1493-0373 93.8 µM -1.00127048365033 0.140359414346458 no 2934 0.15834802936799 4090 3010129 SGTC_204 PMA1.184 62.41 µM -1.00358508371404 0.13980454477373 no 2935 0.157789323628097 4100 2252213 YGL008C PMA1 SGTC_1826 st055655 41.6 µM -1.00446864792427 0.139593125321465 no 2936 0.157576387881796 4111 676168 SGTC_2182 6325192 200 µM -1.00637560423528 0.139137569683223 no 2937 0.157117462174979 4034 736248 SGTC_630 4356-0227 183 µM -1.00671623134969 0.139056303397491 no 2938 0.157035579903875 4064 779312 SGTC_2355 9061122 103.12 µM -1.00807354633433 0.138732798236882 no 2939 0.156709578076048 4116 5302957 SGTC_2157 5649910 96.377 µM -1.00807781121313 0.138731782545729 no 2940 0.156708554433959 4103 2858091 SGTC_905 2-aminofluorene 215 µM -1.00842628102233 0.138648810735093 no 2941 0.156624930734324 4099 1539 An established DNA mutagen. YPR165W RHO1 SGTC_958 1222-0007 33 µM -1.0085747724751 0.138613464704383 no 2942 0.156589305571466 4183 7312461 SGTC_2657 nystatin 74.44 µM -1.00893266785275 0.138528298627365 no 2943 0.156503463422255 4115 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.00918921223403 0.138467272343225 no 2944 0.156441949646079 4101 75037 A free radical scavenger. SGTC_1713 st033146 12.748 µM -1.0114380279776 0.137933112558139 no 2945 0.155903414001841 4103 674619 SGTC_2388 9080168 200 µM -1.01803195715396 0.136374971787584 no 2946 0.154331384639793 4088 15943073 SGTC_2959 9079155 11 µM -1.020821446157 0.135719455904318 no 2947 0.15366952084647 4161 16189457 SGTC_128 0906-2981 13.371 µM -1.02269997129946 0.13527922994314 no 2948 0.153224862489764 4104 6740226 SGTC_1363 1636-0063 10.4 µM -1.02505451104107 0.134728835302883 no 2949 0.152668733799928 4124 6072185 SGTC_1289 0976-0073 69.1 µM -1.02565188683189 0.134589438122162 no 2950 0.152527850307074 4174 3391136 SGTC_1072 oxiconazole 14.9 nM -1.02717421326393 0.134234652117863 no 2951 0.152169219097732 4122 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2258 7960471 200 µM -1.02819605727186 0.133996866722398 no 2952 0.15192880635068 4162 2974708 SGTC_643 k048-0106 28.4 µM -1.02872849694314 0.133873081579025 no 2953 0.151803637486689 4127 6763920 SGTC_784 4579-0127 173 µM -1.03132422340295 0.133270735386915 no 2954 0.15119440129063 4177 1948547 SGTC_1835 st008666 49.2 µM -1.03678417184875 0.132009831477772 no 2955 0.149918226883135 4076 690455 SGTC_2812 7970281 58.44 µM -1.03833707291896 0.131652716883524 no 2956 0.149556577361464 4183 2233435 SGTC_113 0099-0221 2.5 µM -1.03917791374431 0.131459630477907 no 2957 0.149361000143568 4059 89219 SGTC_2568 diosmetin 100 µM -1.03961560551783 0.131359198574009 no 2958 0.149259261866488 4193 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2642 cholecalciferol 100 µM -1.04035577215481 0.131189481947883 no 2959 0.149087320814319 4132 9821465 A vitamin D precursor, similar to steriods. SGTC_1395 3486-0190 4.35 µM -1.04081815716974 0.131083536193447 no 2960 0.148979975726827 4126 6748079 SGTC_3150 9097574 49.47 µM -1.04130037414243 0.130973109344277 no 2961 0.148868081565777 4172 17217476 SGTC_442 cape 100 µM -1.04172489236864 0.130875948622834 no 2962 0.148769622377968 4121 5281787 SGTC_234 nsc-17383 10.7 µM -1.04359762701112 0.13044792502048 no 2963 0.148335795634595 4151 408974 SGTC_2437 5741531 144.16 µM -1.04580183248981 0.129945383564047 no 2964 0.147826267475899 4170 2262990 SGTC_1860 st056228 74.6 µM -1.04697316634138 0.129678874726991 no 2965 0.147555977195175 4112 688679 SGTC_1256 0570-0116 285 µM -1.04854787061479 0.129321185580176 no 2966 0.147193129492062 4145 410638 SGTC_2910 7948405 25.97 µM -1.04899998330242 0.129218616058741 no 2967 0.147089063051119 4060 2971328 SGTC_1497 4476-2978 41.3 µM -1.04957997412647 0.129087117779777 no 2968 0.146955634115144 4181 1528379 SGTC_110 0850-0284 111.64 µM -1.05110007308276 0.128742914070499 no 2969 0.1466063152675 3946 3906265 SGTC_1756 st041558 35.5 µM -1.05467773988932 0.127935319368899 no 2970 0.145786367912551 4237 3955792 SGTC_2841 9004761 38.96 µM -1.05553936450842 0.127741349999145 no 2971 0.145589357981092 4123 2991039 SGTC_2621 lithochol-11-enic acid 100 µM -1.05583018297014 0.127675926963102 no 2972 0.145522902947919 4091 6708711 SGTC_2570 licareol 100 µM -1.0576772952924 0.127260941079666 no 2973 0.145101294918353 4155 443158 SGTC_2385 9074692 200 µM -1.05820018855566 0.127143634623945 no 2974 0.144982092667789 4161 17046906 SGTC_3252 9135871 49.47 µM -1.05909363206575 0.126943372664612 no 2975 0.144778569887743 4176 17682838 SGTC_1270 0831-1170 17.3 µM -1.0591577181214 0.126929016463325 no 2976 0.144763978745212 4176 6764716 SGTC_3324 9138759 60.749 µM -1.06201845940718 0.126289320068094 no 2977 0.144113652584065 4199 45595710 SGTC_2765 myclobutanil 7.74 µM -1.06326913403002 0.126010361100048 no 2978 0.143829959223411 4186 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_950 1165-0508 94.1 µM -1.06500783663357 0.125623263315736 no 2979 0.143436191732924 4177 6148369 SGTC_1744 st037937 38.9 µM -1.06514496914333 0.12559276802186 no 2980 0.143405166052019 4236 1016152 SGTC_2593 nobiletin 86.24 µM -1.06593992668624 0.125416088484447 no 2981 0.14322539936547 4162 72344 An anti-infammatory. SGTC_2595 hexamethylquercetagetin 100 µM -1.06631470235632 0.125332854687587 no 2982 0.143140702772509 4150 386331 SGTC_2728 chlorpromazine 9.18 µM -1.06638915191518 0.125316324803408 no 2983 0.143123881739228 4207 2726 A thorazine and dopamine antagonist. SGTC_1925 st057770 10.1 µM -1.06642652960461 0.125308026484916 no 2984 0.143115437177831 4144 5989122 SGTC_1677 st019204 53.9 µM -1.06718976271558 0.125138662998211 no 2985 0.142943077203575 4186 3945625 SGTC_457 grayanotoxin iii 135 µM -1.0680939756429 0.124938222667815 no 2986 0.142739061542091 3996 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2335 9018011 154.17 µM -1.07027715199373 0.124455194483638 no 2987 0.142247287794907 4164 6458208 SGTC_3130 9127414 49.47 µM -1.07122808969286 0.124245208106324 no 2988 0.142033442157483 4166 1494646 SGTC_3167 9103034 49.47 µM -1.07272607161403 0.123914926148728 no 2989 0.141697019544832 4230 5127859 SGTC_1807 st050092 58.9 µM -1.07318363052252 0.123814164079599 no 2990 0.141594366885485 4191 5008496 SGTC_1236 0330-0013 258 µM -1.07445506415673 0.123534474454561 no 2991 0.141309387208082 4181 4617066 SGTC_1043 0916-0009 19.3 µM -1.07540481801837 0.123325836795115 no 2992 0.141096762826648 4206 3101130 SGTC_205 1486-1330 71.903 µM -1.0762223535603 0.12314644208696 no 2993 0.140913912411744 4196 4118834 SGTC_490 phenamil 164 µM -1.07801144709978 0.122754493265395 no 2994 0.140514323839765 4140 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1604 st002052 72.4 µM -1.07896012781578 0.122547014713787 no 2995 0.140302751287694 4251 6254834 YHR062C RPP1 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.0790238080004 0.122533096535361 no 2996 0.140288557234691 4054 6708630 An antioxidant. SGTC_2762 leflunomide 42.06 µM -1.07993868883584 0.122333259195466 no 2997 0.140084741685945 4147 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1131 3454-3128 32.3 µM -1.0811104485702 0.122077646092338 no 2998 0.139823993079644 4221 710982 SGTC_3279 9140807 49.47 µM -1.08123986019894 0.122049438654709 no 2999 0.139795215694107 4218 45595718 SGTC_1175 0741-0056 27.6 µM -1.08171331544826 0.121946280137974 no 3000 0.139689967316148 4263 765927 SGTC_1087 pterostilbene 9.05 µM -1.08263521451497 0.121745588465032 no 3001 0.139485185183094 4215 5281727 Similar to reservatol, lowers cholesterol. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.08359324390194 0.121537277459831 no 3002 0.139272593847732 4149 6857784 SGTC_2683 piperine 63.03 µM -1.08392463926845 0.121465278210513 no 3003 0.139199106969033 4153 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2479 5617353 43.85 µM -1.08717171196964 0.12076140232171 no 3004 0.138480464993074 4221 2731746 SGTC_2802 7925815 54.55 µM -1.09014400115722 0.120119613231327 no 3005 0.137824858155855 4151 1262923 SGTC_1458 k015-0034 6.33 µM -1.09017873653396 0.120112127259723 no 3006 0.137817209008138 4213 3598957 SGTC_2492 derrusnin 100 µM -1.09048343163331 0.120046475188708 no 3007 0.137750123896686 4176 1715307 Part of coumarin class of compounds. SGTC_698 k064-0052 127 µM -1.09151872520656 0.119823591436302 no 3008 0.137522348484352 4268 5088751 SGTC_3177 9107506 49.47 µM -1.0929508887207 0.119515748538616 no 3009 0.137207681598711 4141 8897194 SGTC_2149 5554786 194.827 µM -1.09354914175951 0.119387319673799 no 3010 0.137076382557623 4203 745063 YPR165W RHO1 SGTC_1366 1683-0113 21.9 µM -1.09510260275405 0.119054288135481 no 3011 0.136735844275055 4197 708623 SGTC_202 3594-0513 34.79 µM -1.09520744922632 0.119031834762108 no 3012 0.136712881456744 4222 708429 SGTC_415 dibenzyl ketone 100 µM -1.09797936442675 0.118439300044691 no 3013 0.136106750083534 4170 7593 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.09964946535985 0.118083301264293 no 3014 0.13574244040386 4168 16623 A steroid. SGTC_174 3553-0389 74.3 µM -1.10093065667521 0.117810715929067 no 3015 0.13546341913505 4274 738071 SGTC_1272 0839-0021 27 µM -1.1015507570516 0.117678943851276 no 3016 0.135328513263791 4214 5027250 SGTC_129 0088-0017 176.636 µM -1.10270134514129 0.117434718924985 no 3017 0.135078441224037 4069 182446 SGTC_46 0329-0187a 2.197 µM -1.10483587740683 0.116982592039537 no 3018 0.13461535569873 4245 46494817 SGTC_2816 7982706 58.44 µM -1.1050824802963 0.116930437338993 no 3019 0.134561925645525 4223 2981853 SGTC_642 0335-0876 158 µM -1.10540322767295 0.116862626283559 no 3020 0.134492452908036 4239 6812350 SGTC_433 pimozide 108 µM -1.10543341854994 0.11685624489153 no 3021 0.134485914939965 4101 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3008 9078912 71.4286 µM -1.10713785761575 0.11649638114855 no 3022 0.134117164950419 4194 16648731 SGTC_633 0437-0093 97.7 µM -1.10930004786001 0.116041002901967 no 3023 0.133650382232845 4140 2831118 SGTC_978 1416-0512 87.4 µM -1.11032057238498 0.115826510040061 no 3024 0.133430455594453 4286 6814003 SGTC_2307 7538926 6.34 µM -1.11140217391518 0.115599487562148 no 3025 0.133197638509284 4173 96582 SGTC_2674 ligustilide 100 µM -1.11215599675675 0.115441451155457 no 3026 0.133035541903846 4255 5319022 A signalling regulator. SGTC_3263 9137018 49.47 µM -1.11321074806868 0.115220583904582 no 3027 0.132808963819436 4170 43844957 SGTC_323 4013-0906 34.3 µM -1.11388675650879 0.115079184308871 no 3028 0.132663885806088 4223 2910086 SGTC_3040 9091894 49.47 µM -1.11626539348906 0.114582629702906 no 3029 0.132154275105065 4057 25236966 SGTC_3084 9116877 49.47 µM -1.11853473374904 0.114110314624849 no 3030 0.131669340278879 4148 27241325 SGTC_1268 0828-0275 2.46 µM -1.11875446059095 0.114064656885262 no 3031 0.131622452186604 4269 745337 SGTC_335 4077-0256 27.6 µM -1.12808552487282 0.112137722826012 no 3032 0.129641900853903 4184 3121989 SGTC_1485 3909-9022 254 µM -1.12871920737973 0.11200771156583 no 3033 0.129508152032648 4268 714516 SGTC_955 1216-0110 33 µM -1.13113031233821 0.111514015625783 no 3034 0.129000123830152 4205 3619719 SGTC_895 0964-0006 13.7 µM -1.13118971553926 0.111501871959652 no 3035 0.128987624837004 4195 6738897 SGTC_674 0498-0004 451 µM -1.13144140307745 0.11145043052709 no 3036 0.128934676725249 4201 4231473 SGTC_3007 9078383 71.4286 µM -1.13239755630168 0.111255160935832 no 3037 0.128733665892705 4209 6496995 SGTC_48 0382-0018 55 µM -1.13256461762543 0.111221068128922 no 3038 0.128698567135799 4292 762596 SGTC_1722 st034304 3.6505 µM -1.1357162602114 0.110579302167379 no 3039 0.12803766658925 4195 4036148 YLR033W RSC58 SGTC_1084 voriconazole 435 nM -1.13656470702614 0.11040698811342 no 3040 0.127860150494854 4229 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_358 0075-0058 9.45 µM -1.13694988438552 0.110328824658636 no 3041 0.127779618319705 4052 1069125 SGTC_2968 9090663 33.37 µM -1.13707772834918 0.110302890251002 no 3042 0.127752896732309 4189 25236811 SGTC_596 1155-0152 116 µM -1.13962935213576 0.109786182360108 no 3043 0.127220375712669 4219 280313 SGTC_2278 7948257 134.34 µM -1.14079433273987 0.109550850507859 no 3044 0.126977759777823 4233 1247028 SGTC_1767 st044992 70.3 µM -1.14391201687594 0.108922845262624 no 3045 0.126330063458541 4272 9600693 SGTC_2916 7875993 68.79 µM -1.14974133640158 0.10775557818488 no 3046 0.125125211776319 4076 1299250 SGTC_1021 4476-0760 85.3 µM -1.15147519714375 0.107410133721158 no 3047 0.124768396698052 4243 746768 SGTC_1140 3229-1848 2.98 µM -1.15242761353146 0.107220719757163 no 3048 0.124572699651956 4263 2849525 SGTC_2444 5485484 36.41 µM -1.1545006805512 0.106809266778515 no 3049 0.124147479857588 4322 6790631 SGTC_1241 0364-0022 50.8 µM -1.15620397976373 0.106472057205777 no 3050 0.12379886618058 4255 4563895 SGTC_2972 9093619 59.92 µM -1.15694597917536 0.10632540094629 no 3051 0.123647215900171 4197 25236256 SGTC_976 1348-1067 47.6 µM -1.16334449509896 0.105066783610649 no 3052 0.122344879805334 4254 5310671 YGL099W LSG1 SGTC_403 arphamenine a 50 µM -1.16723386074241 0.104307016629179 no 3053 0.121557970022218 4233 5487158 An arginine aminopeptidase inhibitor. SGTC_1307 1187-1599 12.2 µM -1.16928954932335 0.103907060899435 no 3054 0.121143496135963 4242 1538471 SGTC_1663 st014140 55.4 µM -1.17068445976972 0.10363630063825 no 3055 0.120862816987276 4331 4207120 SGTC_2720 fluspirilene 36.88 µM -1.17399879549912 0.102995022804031 no 3056 0.120197754041512 4243 3396 An atypical antipsychotic. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.17400207763109 0.102994389189054 no 3057 0.120197096721201 4392 16725076 SGTC_1237 0330-0133 46.1 µM -1.17546240255079 0.10271275456198 no 3058 0.119904885231386 4200 X1237 YHR072W ERG7 SGTC_212 3807-4682 38.772 µM -1.17644900738794 0.102522797479878 no 3059 0.119707748971551 4330 3125501 YBL034C STU1 SGTC_1390 3413-2614 145 µM -1.17911753652585 0.102010289117573 no 3060 0.119175688272525 4286 3421432 SGTC_214 4373-3496 70 µM -1.18202889971824 0.101453272205124 no 3061 0.118597116997502 4358 3779166 SGTC_2857 9024691 58.44 µM -1.18372089621065 0.10113057039912 no 3062 0.11826178218621 4343 16478292 SGTC_2996 9066192 71.4286 µM -1.18985410836315 0.099967099717604 no 3063 0.117051869209179 4300 6472854 SGTC_1651 st011928 86.1 µM -1.1930705791652 0.0993608566618738 no 3064 0.116420866344386 4289 720198 SGTC_1975 st070967 30.8 µM -1.19389929657362 0.0992050956787496 no 3065 0.116258681362868 4267 261391 SGTC_1632 st005650 90 µM -1.19579320887141 0.0988497972175807 no 3066 0.11588863336756 4308 2759605 SGTC_1243 0416-0003 5.65 µM -1.19658478213753 0.0987015740802283 no 3067 0.115734217428771 4278 2141977 SGTC_1534 6-azauridine 81.6 µM -1.19877706024552 0.0982919163500483 no 3068 0.115307322346785 4309 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3012 9080433 71.4286 µM -1.19991530073971 0.098079712022764 no 3069 0.115086118472783 4281 17688859 SGTC_1806 st050005 60.3 µM -1.20219902764104 0.0976549652222329 no 3070 0.114643212985445 4334 5194765 SGTC_1204 4049-0315 18.3 µM -1.20248108802796 0.0976025989714387 no 3071 0.11458859452948 4338 588402 SGTC_1469 k284-2957 126 µM -1.2030008832593 0.0975061497247917 no 3072 0.114487989376313 4286 23884841 SGTC_1936 st074407 74.3 µM -1.20428396667536 0.0972683698072033 no 3073 0.114239920773313 4319 809813 SGTC_1755 st041960 45.185 µM -1.21436682931073 0.095414615410515 no 3074 0.112303838120321 4322 2257073 SGTC_1657 st012939 43.4 µM -1.21648834514952 0.0950279040281402 no 3075 0.111899474074044 4310 24207257 SGTC_444 curcumin 90.4 µM -1.21710906798856 0.0949149768439308 no 3076 0.111781360506704 4230 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3259 9138485 49.47 µM -1.21878716686476 0.0946101778082677 no 3077 0.111462491772853 4310 17646153 SGTC_1791 st048313 56.1 µM -1.22014056084689 0.094364882149744 no 3078 0.111205797385339 4308 1204976 SGTC_184 1494-0393 24.714 µM -1.22108271599932 0.0941943985020938 no 3079 0.111027351558271 4265 3090647 SGTC_1397 3532-0190 20.1 µM -1.22136760328165 0.094142892709823 no 3080 0.110973433814345 4243 5322280 SGTC_85 0868-0259 160.055 µM -1.22358334563514 0.0937430097603866 no 3081 0.110554722707458 4210 83173 SGTC_3109 9122853 49.47 µM -1.22374255117755 0.0937143257267757 no 3082 0.110524681138677 4335 1234709 SGTC_429 1112-0049 25.5 µM -1.22581650062993 0.0933412544720006 no 3083 0.110133868160321 4295 2836170 SGTC_2428 5615643 7.78 µM -1.22781238507532 0.0929832630189481 no 3084 0.109758702655747 4311 2253075 SGTC_2757 clomiphene 4.22 µM -1.23060009708639 0.0924849458193156 no 3085 0.109236234460655 4335 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1903 st060211 78.3 µM -1.23290746174035 0.0920739898240675 no 3086 0.108805145616067 4337 688960 SGTC_678 1218-2179 85.9 µM -1.23609442646644 0.0915085971303291 no 3087 0.108211733192223 4330 6820081 YOR116C RPO31 SGTC_1978 st071761 42 µM -1.23613563254338 0.0915013037345495 no 3088 0.108204075910705 4342 5147680 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.23974939949052 0.0908633484349864 no 3089 0.107534049652467 4295 6312947 SGTC_2007 4011539 71.82 µM -1.24982601013055 0.0891019150314026 no 3090 0.105681556213242 4276 45595301 SGTC_901 1112-0062 60.1 µM -1.25158620861179 0.088796850058747 no 3091 0.10536034126853 4329 1908457 SGTC_251 melphalan 456.522 µM -1.25235212449326 0.088664350116732 no 3092 0.105220791621301 4368 460612 A DNA alkylator. SGTC_2120 5538279 151.968 µM -1.26312369221768 0.0868164879655178 no 3093 0.103272365359558 4298 2058197 SGTC_430 0958-0115 16.4 µM -1.26776407769376 0.0860293577756876 no 3094 0.102441107030484 4280 6833180 SGTC_1246 0422-0085 105 µM -1.26794974165852 0.0859979757968462 no 3095 0.10240794951857 4369 264295 SGTC_3029 9088683 49.47 µM -1.26967454310043 0.0857068493549188 no 3096 0.102100292178082 4375 25236615 SGTC_2339 9000433 200 µM -1.27139712762569 0.0854168341199616 no 3097 0.101793701990723 4347 2988954 SGTC_723 4182-0001 115 µM -1.27235103931648 0.0852565495985824 no 3098 0.101624210834809 4358 744821 YLR208W SEC13 SGTC_1772 st048439 82.2 µM -1.27258866968292 0.0852166559645002 no 3099 0.101582020629722 4396 2927068 YDL195W SEC31 SGTC_1015 4130-4525 82 µM -1.27370645663639 0.085029188344036 no 3100 0.101383733681406 4350 1363237 SGTC_1928 4'-methoxychalcone 40.3 µM -1.27383742780135 0.0850072429982817 no 3101 0.101360518854368 4370 641818 SGTC_1427 4048-4900 550 nM -1.2752388297161 0.0847726917292103 no 3102 0.101112360720554 4339 24132586 SGTC_1821 st053465 65.6 µM -1.2768995920745 0.084495360264012 no 3103 0.100818849094139 4363 675086 SGTC_1093 fluphenazine 7.97 µM -1.27702166510943 0.0844750021179251 no 3104 0.100797299289385 4377 6602611 An atypical antipsychotic. SGTC_585 0kpi-0023 191 µM -1.27894902520661 0.0841540634069633 no 3105 0.100457503501306 4284 64601 SGTC_2872 9044037 25.97 µM -1.28290442630778 0.0834982888750228 no 3106 0.0997627809650741 4393 6465195 SGTC_1942 st076330 65.2 µM -1.28293685249844 0.0834929287825893 no 3107 0.0997571002039013 4411 24208414 SGTC_628 1636-0253 16 µM -1.2837083005148 0.0833654836446231 no 3108 0.0996220195069924 4348 4456143 SGTC_1659 st012954 42.1 µM -1.28732302102965 0.0827702700427543 no 3109 0.0989908614081564 4309 24207262 SGTC_2963 9082507 9 µM -1.29159738079306 0.0820705707159165 no 3110 0.0982483057906317 4379 16459611 SGTC_2431 5490079 200 µM -1.29314050467901 0.081819063951142 no 3111 0.0979812341526724 4396 5722345 SGTC_2610 ononetin 44.17 µM -1.29369219896992 0.0817292869112664 no 3112 0.0978858805020575 4336 259632 SGTC_3265 9137266 49.47 µM -1.29707826929892 0.0811798986055625 no 3113 0.0973021288311769 4319 17224265 SGTC_1555 citronellol 128 µM -1.29797671045706 0.0810345957857745 no 3114 0.0971476690245237 4338 8842 A terpine precursor. SGTC_1665 st014639 11.4 µM -1.29859163575762 0.0809352585396975 no 3115 0.0970420549780319 4439 981133 YIL048W NEO1 SGTC_3352 9151559 45.5865 µM -1.29925074012874 0.080828886543563 no 3116 0.09692894673615 4379 17159339 SGTC_2481 5478948 45.16 µM -1.29991534934133 0.0807217330407473 no 3117 0.096814991848002 4376 77792 SGTC_1519 esterone 74 µM -1.30052159153997 0.0806240835093622 no 3118 0.0967111304793827 4334 698 A steroid. SGTC_816 0325-0417 81.3 µM -1.30197056622706 0.0803910536203961 no 3119 0.096463223815137 4404 68101 SGTC_1301 naphtanilide LB 4.81 µM -1.30999833923482 0.0791092068358503 no 3120 0.0950981987085952 4432 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2678 equilin 100 µM -1.31478913523778 0.0783516386289368 no 3121 0.0942903899435313 4364 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1336 1486-0901 104 µM -1.31837888324746 0.0777876067217441 no 3122 0.093688423067491 4382 5006114 SGTC_3354 9151612 71.43 µM -1.31931115154678 0.0776416312751115 no 3123 0.0935325556042272 4381 27261949 SGTC_3300 9124615 50.48 µM -1.31984810945076 0.0775576483436084 no 3124 0.0934428676944007 4423 24824903 SGTC_1388 3346-4487 254 µM -1.32386124069628 0.0769321571758684 no 3125 0.0927745663727907 4447 3345614 SGTC_776 4476-4378 112 µM -1.32588873987458 0.0766176104488709 no 3126 0.0924382766337584 4434 2892008 SGTC_2953 9074162 66.49 µM -1.32607351829145 0.0765889925837181 no 3127 0.0924076733948162 4369 16451992 SGTC_2649 anisomycin 9.56 µM -1.33031861478488 0.0759337629700831 no 3128 0.0917066582618272 4421 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3239 9133757 49.47 µM -1.33062282569446 0.0758869724984146 no 3129 0.0916565740140293 4442 17036923 SGTC_282 k297-0036 65.7 µM -1.33123279595728 0.075793219543792 no 3130 0.0915562116510313 4398 5061378 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.33205310742073 0.0756672760936621 no 3131 0.0914213689239546 4344 676296 Flavone; oxidizing agent. SGTC_506 n9-isopropylolomoucine 153 µM -1.33691299538561 0.0749243993719761 no 3132 0.0906255191895743 4397 6610355 SGTC_1149 3909-7961 23.3 µM -1.33808600019312 0.0747459314710347 no 3133 0.0904342019470421 4448 735261 SGTC_2705 st078069 42.8 µM -1.34134981548253 0.0742510622011655 no 3134 0.0899034515187567 4429 1530061 SGTC_2200 6600604 21.907 µM -1.343770200932 0.0738856949524324 no 3135 0.0895113542051563 4426 2904777 SGTC_1870 st057514 26.5 µM -1.34455730790011 0.0737671744024243 no 3136 0.0893841189791879 4399 5393161 SGTC_974 1326-0144 138 µM -1.34983374772738 0.0729764106535304 no 3137 0.0885346585224153 4424 5411856 SGTC_934 2950-0684 338 µM -1.35054191882856 0.0728707749401472 no 3138 0.0884211084820259 4413 1121253 SGTC_618 k072-0232 33.2 µM -1.35805135834039 0.0717578058135814 no 3139 0.0872236940828792 4449 5872756 YGL099W LSG1 SGTC_2838 9002687 71.43 µM -1.3585527668242 0.0716839593209873 no 3140 0.0871441755323154 4389 6457060 SGTC_787 4152-0075 138 µM -1.36169042875024 0.0712231736164791 no 3141 0.0866478015560335 4423 9566539 SGTC_604 1000-0114 314 µM -1.36718653748117 0.0704215198461372 no 3142 0.0857834219928314 4421 1572745 SGTC_116 0155-0182 31.788 µM -1.37128773142062 0.0698278593703679 no 3143 0.085142639336493 4275 771486 SGTC_1067 clotrimazole 1.36 µM -1.37135391931716 0.0698183101486115 no 3144 0.0851323274353565 4458 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2320 7373003 200 µM -1.37877422244896 0.0687541092671444 no 3145 0.0839821884169544 4423 5415828 SGTC_1799 st045822 46.1415 µM -1.38028096485686 0.0685395518728132 no 3146 0.0837500767416263 4406 3674992 SGTC_2703 st077852 53.4 µM -1.38902283895513 0.067304901396279 no 3147 0.0824129026006673 4452 6281836 SGTC_1802 st050112 57.9 µM -1.39121001892829 0.0669987023149758 no 3148 0.0820808749936303 4435 4662563 SGTC_2643 anethole 100 µM -1.39353763753936 0.0666740268434997 no 3149 0.0817286358928809 4424 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2014 4013930 200 µM -1.3951581149884 0.0664487091518015 no 3150 0.0814840822516174 4405 64556 SGTC_2261 9010538 184.68 µM -1.39571345275607 0.0663716285360276 no 3151 0.0814004007885249 4425 6457250 SGTC_366 0181-0206 4.31 µM -1.39592510337229 0.0663422697602782 no 3152 0.0813685251314137 4430 274874 SGTC_3120 9124077 49.47 µM -1.39596073846648 0.0663373276846015 no 3153 0.0813631592315436 4549 18774327 YGL155W CDC43 SGTC_2755 lomerizine 42.69 µM -1.3985443470856 0.0659797773213284 no 3154 0.0809748326122722 4364 3949 A calcium channel blocker. SGTC_144 4161-2749 112.381 µM -1.39863781907115 0.0659668696053998 no 3155 0.0809608096698896 4421 797501 YMR168C CEP3 SGTC_1738 st035555 74 µM -1.39988734242609 0.0657945085095834 no 3156 0.0807735284970419 4454 5331140 SGTC_2393 9031399 185.94 µM -1.40240198256662 0.0654486936825501 no 3157 0.0803976208382253 4430 1526623 YDL150W RPC53 SGTC_638 3970-0837 4.09 µM -1.40341635991175 0.0653095955730364 no 3158 0.0802463586484694 4426 4118451 YLR208W SEC13 SGTC_3083 9117465 49.47 µM -1.40551352301211 0.0650227460452114 no 3159 0.0799343154718161 4401 16420915 SGTC_2075 5212009 200 µM -1.40575175943912 0.0649902220656076 no 3160 0.0798989256776046 4365 780898 SGTC_516 3992-2719 87.3 µM -1.40881333848106 0.0645733790339974 no 3161 0.0794451849946046 4344 5350887 YDR037W KRS1 SGTC_3353 9151644 39.2805 µM -1.40944163214295 0.0644880923876984 no 3162 0.0793523105038666 4453 4909158 SGTC_1318 1280-3875 124 µM -1.41481756648475 0.0637619190881297 no 3163 0.0785609961277366 4444 373245 SGTC_1553 gossypol 38.6 µM -1.42160320554505 0.0628544253678122 no 3164 0.0775707368430128 4353 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_686 1319-0111 510 µM -1.42487300833265 0.062420738771526 no 3165 0.077096956633268 4462 4562600 SGTC_1034 k072-0165 12.7 µM -1.42926982149668 0.0618412549264633 no 3166 0.0764633481897491 4471 5835461 SGTC_1368 1852-0141 284 µM -1.43508908964459 0.0610807635182856 no 3167 0.0756308560846047 4439 2838987 SGTC_423 5-fluorouracil 457 µM -1.43602750956246 0.0609588134050536 no 3168 0.0754972567591097 4396 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2374 9071832 200 µM -1.43859777350038 0.060625775446949 no 3169 0.0751322587797265 4396 17381698 SGTC_551 k048-0028 34.9 µM -1.43875496449017 0.060605453943549 no 3170 0.0751099801439555 4428 6836383 SGTC_1212 0520-0165 585 µM -1.43897837005236 0.0605765814511003 no 3171 0.0750783256030726 4514 5403258 SGTC_1887 st057648 70.8 µM -1.44343845264332 0.0600024181309273 no 3172 0.0744484992949016 4455 688672 SGTC_2727 riluzole 51.77 µM -1.44536526632119 0.0597556941831016 no 3173 0.0741776571276697 4501 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2565 isoliquiritigenin 100 µM -1.44630486682105 0.0596356692015018 no 3174 0.0740458556581236 4490 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2869 9037858 32.47 µM -1.44955041851703 0.0592225338194944 no 3175 0.0735919654449022 4436 27187042 SGTC_2730 imipramine 71.33 µM -1.44955543403661 0.05922189712129 no 3176 0.0735912656747512 4434 3696 A tricyclic antidepressant. SGTC_1871 st057448 67.3 µM -1.45270608374718 0.0588229956701251 no 3177 0.0731526885619061 4461 691747 SGTC_2349 9023730 187.07 µM -1.45324243371689 0.0587552993089375 no 3178 0.0730782271330062 4506 4126287 SGTC_2376 9072922 81.32 µM -1.45472751716049 0.058568175898904 no 3179 0.0728723557426001 4461 17087968 SGTC_3344 9148862 3.898 µM -1.45767821997359 0.0581977702415518 no 3180 0.0724646290255728 4495 4905352 SGTC_2323 6148992 148.28 µM -1.45871289662364 0.0580683225971225 no 3181 0.0723220724966282 4423 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_544 k015-0020 52.4 µM -1.46110101072451 0.0577704111723258 no 3182 0.0719938614510068 4497 3008304 SGTC_1570 verbenone 133 µM -1.46140272445291 0.0577328587735086 no 3183 0.0719524767360199 4496 29025 A natural terpanoid with antifungal properties. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.46236839294636 0.0576127971389998 no 3184 0.0718201429492566 4498 6708784 An antioxidant flavonoid SGTC_2399 5884133 200 µM -1.46303591753574 0.0575299186048428 no 3185 0.0717287755330646 4437 722445 SGTC_1094 duloxetine 25.4 µM -1.46691239599299 0.0570504748732801 no 3186 0.0711999439827117 4488 60834 A selective serotonin reuptake inhibitor. SGTC_1979 st071809 45.3 µM -1.46755476405251 0.0569713313337709 no 3187 0.0711126016078846 4519 4976333 SGTC_3194 9111903 49.47 µM -1.47404648658131 0.056176355763394 no 3188 0.070234537631596 4481 17087251 SGTC_2277 7947813 106.88 µM -1.474531030489 0.0561173711395634 no 3189 0.070169334606928 4494 1246798 SGTC_2 0422-0095 29 µM -1.47963975117349 0.0554984429908089 no 3190 0.0694847060609087 4395 6790840 SGTC_168 3970-0862 530.542 µM -1.48524442109876 0.0548256425603996 no 3191 0.0687395443850768 4413 3135186 SGTC_1874 staurosporine 7.6 µM -1.49230166537863 0.0539876594496186 no 3192 0.0678100401813978 4483 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1690 st023502 41.2 µM -1.50658890944409 0.0523222411189616 no 3193 0.0659580309610328 4501 24207482 SGTC_2044 5102272 200 µM -1.50992604533913 0.0519391798964585 no 3194 0.0655311479695999 4497 592666 SGTC_2064 5220758 200 µM -1.51063994557446 0.0518575231881637 no 3195 0.0654401053852484 4530 788518 SGTC_1879 gemcitabine 100 µM -1.5251727105572 0.0502173224381983 no 3196 0.0636080126474179 4462 60750 A nucleoside analog which inhibits DNA replication. SGTC_1715 st032160 10.2275 µM -1.52607122086477 0.0501172875980922 no 3197 0.0634960641973097 4412 5289825 SGTC_166 k072-0058 166.424 µM -1.52910865893445 0.049780293008725 no 3198 0.0631187545612929 4384 5846229 SGTC_803 4488-1585 147 µM -1.52912659894848 0.0497783080015665 no 3199 0.0631165312564797 4506 747204 SGTC_277 nystatin 15.5 µM -1.53137485216724 0.0495300451163632 no 3200 0.0628383878157977 4533 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_648 0375-0473 33.3 µM -1.53283189533029 0.0493696798667063 no 3201 0.0626586398567014 4493 1713139 SGTC_3246 9135460 32.98 µM -1.53301629760977 0.0493494137459674 no 3202 0.0626359196884651 4495 41446951 SGTC_2766 oltipraz 83.91 µM -1.54083909534325 0.0484957755365262 no 3203 0.0616779758965548 4496 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2888 9058547 12.99 µM -1.54101585906699 0.048476624039784 no 3204 0.0616564631274597 4453 16476514 SGTC_2080 5212524 12.4 µM -1.5428535046976 0.0482778820700486 no 3205 0.0614331620773022 4465 260183 SGTC_2222 6885208 172.143 µM -1.54717968012769 0.0478125779436428 no 3206 0.0609099621970646 4539 609514 SGTC_1210 3013-0140 750 nM -1.54729748172297 0.0477999581253028 no 3207 0.0608957643595135 4535 905973 SGTC_2675 theaflavin digallate 100 µM -1.5544151334914 0.0470423959045192 no 3208 0.0600427128502552 4454 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2098 5376439 882.5 nM -1.55499422165845 0.0469811869515182 no 3209 0.0599737227575688 4567 2844116 SGTC_1255 0566-0045 221 µM -1.55829261139707 0.0466337678323056 no 3210 0.0595819498246609 4533 2788469 SGTC_837 0091-0265 12.5 µM -1.55987230749323 0.0464681102186034 no 3211 0.0593950298987982 4526 759367 SGTC_2884 9058502 51.95 µM -1.5611238422507 0.0463372014521223 no 3212 0.059247266797747 4507 6471554 SGTC_106 0092-0003 11.579 µM -1.56368096125451 0.0460706509818289 no 3213 0.0589462555170222 4447 1072148 SGTC_3051 9093778 49.47 µM -1.56419249076636 0.0460174779893712 no 3214 0.0588861850861621 4621 17217378 SGTC_2112 5488546 200 µM -1.56636618183568 0.0457920745767856 no 3215 0.0586314576725672 4487 600757 SGTC_962 1254-0300 21.5 µM -1.5668628027467 0.0457407016209009 no 3216 0.0585733819350151 4515 7340576 SGTC_1716 st033144 30.6155 µM -1.57727197619104 0.0446745464646968 no 3217 0.057366478843308 4497 674617 SGTC_1921 5740136 50 µM -1.57917884761476 0.0444814223187073 no 3218 0.0571475201389896 4472 1774243 SGTC_1065 prochlorperazine maleate 2.48 µM -1.58120726850844 0.0442767267764121 no 3219 0.0569153269915195 4569 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3209 9113616 49.47 µM -1.58394964386462 0.0440011912421391 no 3220 0.0566025894243172 4572 16649353 SGTC_711 k292-0785 179 µM -1.58610115132642 0.0437859915024449 no 3221 0.0563581828752549 4486 4146315 SGTC_2541 muurolladie-3-one 83.07 µM -1.58753675011324 0.0436428718130441 no 3222 0.0561955652284479 4468 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1466 k213-0079 57.5 µM -1.58981151790838 0.0434168657483679 no 3223 0.0559386484273306 4530 3657981 SGTC_2490 carminic acid 95.39 µM -1.5926142331051 0.0431397065399545 no 3224 0.0556233792831364 4533 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1052 3253-3998 198 µM -1.59301206196212 0.0431004815088087 no 3225 0.0555787425773262 4496 5450317 SGTC_59 0330-0160 1.33 µM -1.59559874227267 0.0428461427986072 no 3226 0.0552892042620129 4491 4293482 SGTC_502 l-744,832 89.3 µM -1.61611434870688 0.0408716145775645 no 3227 0.0530347962487993 4566 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1957 st077035 62.4 µM -1.61993969126681 0.0405117388096821 no 3228 0.0526226162950126 4571 705593 SGTC_75 0159-0059 199.013 µM -1.62177396439759 0.0403400911335881 no 3229 0.0524258775197834 4586 5377270 SGTC_2353 9059630 146.67 µM -1.63182593710433 0.0394099060050288 no 3230 0.0513580798624631 4596 4779114 SGTC_1488 4013-0813 75.9 µM -1.64005266731374 0.038661675492932 no 3231 0.0504971083589404 4568 2910057 SGTC_2917 7979103 53.79 µM -1.64439737084785 0.0382712144956716 no 3232 0.0500470739254709 4555 2980565 SGTC_2844 9010103 25.97 µM -1.64741042067848 0.0380023227561387 no 3233 0.049736857446276 4521 2480525 SGTC_537 1334-0398 209 µM -1.65801259559988 0.0370683881308695 no 3234 0.0486574620426625 4585 5846986 SGTC_2460 5552655 174.22 µM -1.663799967908 0.0365665520077044 no 3235 0.0480762052068167 4546 5401989 SGTC_1 0258-0098 57.368 µM -1.6685259534077 0.0361608860345367 no 3236 0.047605682130835 4500 6790032 YDR047W HEM12 SGTC_1681 tripelennamine 100 µM -1.67525035079588 0.0355900405957439 no 3237 0.0469425611520897 4486 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_569 4130-2812 160 µM -1.67704483194052 0.0354389591070109 no 3238 0.0467668577182478 4465 743552 SGTC_3151 9099821 49.47 µM -1.67776073433436 0.0353788325776048 no 3239 0.0466969087960149 4519 17174189 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.69418562111645 0.0340221773487126 no 3240 0.0451150081403004 4555 364106 SGTC_2732 terfenadine 20 µM -1.69528777994711 0.0339326947946749 no 3241 0.0450104209136238 4658 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1684 st024538 14.6195 µM -1.69545069594737 0.0339194843352328 no 3242 0.0449949778835363 4573 6732859 SGTC_365 0121-0052 13.6 µM -1.6985279380004 0.0336707518799392 no 3243 0.0447040821569682 4569 3101739 SGTC_131 0141-0277 33.849 µM -1.70340390658972 0.0332797039003526 no 3244 0.0442462535668801 4547 1547771 SGTC_1507 4075-3230 155 µM -1.70645098978285 0.0330372353749155 no 3245 0.0439620719628611 4555 659771 SGTC_981 1488-1094 54.9 µM -1.71198077933788 0.0326009264483687 no 3246 0.043450105314237 4569 3449522 SGTC_1138 3761-0006 1.03 µM -1.71259929552338 0.0325524214381897 no 3247 0.0433931414975166 4622 12061087 SGTC_1626 st003712 1.76 µM -1.71936496119925 0.0320257239354312 no 3248 0.0427739690781318 4591 24207035 SGTC_3182 9108849 49.47 µM -1.72080310210159 0.0319146784165967 no 3249 0.0426432796650033 4590 17133045 SGTC_1625 st003711 30.1 µM -1.72564828667471 0.0315428974345299 no 3250 0.0422053533719264 4605 24207034 YER133W GLC7 SGTC_1209 2323-2347 50.3 µM -1.73318596896115 0.0309716374123486 no 3251 0.0415313100372616 4615 5412760 SGTC_1545 lovastatin 49.4 µM -1.7530082906543 0.0295101094456911 no 3252 0.0398002919989032 4640 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_247 mechlorethamine 29.705 µM -1.76021700619273 0.0289929999042057 no 3253 0.0391855098049691 4589 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2974 9094440 9.66 µM -1.76562593620881 0.0286099600513752 no 3254 0.0387293128874741 4585 25236134 SGTC_1550 gossypolone 36.6 µM -1.76598933391886 0.0285843772081611 no 3255 0.0386988191592366 4632 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.76701306558103 0.0285124097863321 no 3256 0.0386130201003596 4586 1241132 A phosphatase inhibitor. SGTC_728 3030-5151 22.5 µM -1.76724103317541 0.0284964044050061 no 3257 0.0385939352288048 4669 3125388 SGTC_148 3253-0744 288.01 µM -1.77064444083618 0.0282583419509461 no 3258 0.0383099234383899 4509 6893655 SGTC_364 0083-0097 67.7 µM -1.77526815830166 0.0279375751773793 no 3259 0.0379268101786859 4617 5207356 SGTC_3082 9117008 49.47 µM -1.7757365949736 0.0279052476162553 no 3260 0.0378881713358203 4638 41448529 SGTC_3068 9116768 49.47 µM -1.7840240089055 0.0273384529864438 no 3261 0.0372098819799786 4578 41904888 SGTC_325 2810-4341 181 µM -1.79140136711024 0.0268420081075513 no 3262 0.036614454854623 4626 774970 SGTC_66 0109-0187 42.4 µM -1.81130249516951 0.0255402149186448 no 3263 0.0350470198352781 4470 759417 SGTC_1467 k284-1082 293 µM -1.82237731489296 0.0248389609798941 no 3264 0.034198877116427 4613 3334705 SGTC_1704 st028805 70.8 µM -1.82485195521225 0.0246844946262668 no 3265 0.034011686538629 4663 2876101 SGTC_376 3970-0862 59.1 µM -1.82738165301502 0.0245274254148792 no 3266 0.0338212029718478 4644 3135186 SGTC_2402 5553605 200 µM -1.8411768680086 0.0236855667917875 no 3267 0.0327978220184508 4652 6758546 SGTC_2351 9026858 72.31 µM -1.84546899272935 0.0234286465581912 no 3268 0.0324846725045216 4549 1409300 SGTC_95 0471-0001 561.058 µM -1.86383734948665 0.0223554812799989 no 3269 0.0311722744833291 4628 4015405 SGTC_373 0844-0104 25.9 µM -1.86634458139974 0.0222122644217372 no 3270 0.0309965856282923 4658 5375804 SGTC_2418 pentamidine 31.67 µM -1.86923428499326 0.0220481613191449 no 3271 0.0307951131350017 4590 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_887 0885-0007 9.62 µM -1.87958364385262 0.0214688044904647 no 3272 0.0300824220600101 4660 5719458 SGTC_2701 st077767 14.721 µM -1.88066264644163 0.0214091495426078 no 3273 0.0300089119877773 4641 5721188 SGTC_2244 6635614 200 µM -1.88177256042732 0.0213479318724916 no 3274 0.0299334514710417 4624 836499 SGTC_2585 alliin 100 µM -1.89059513711319 0.0208665640656758 no 3275 0.029339204948806 4640 87310 A garlic compound which reacts with lipids. SGTC_1278 0874-0585 172 µM -1.89208559934049 0.0207861572080533 no 3276 0.0292397883508079 4683 766306 SGTC_1303 1160-0052 261 µM -1.89358931344285 0.0207053014493142 no 3277 0.0291397715393035 4617 3562476 SGTC_2962 9082311 13.18 µM -1.89582919983102 0.0205853551623724 no 3278 0.028991316692718 4640 16459453 SGTC_1170 0310-0127 64.8 µM -1.89647533901638 0.0205508638869608 no 3279 0.0289486089712162 4660 774975 SGTC_2913 7966556 36.57 µM -1.89868538155693 0.0204332604599692 no 3280 0.0288029273698571 4565 2976516 SGTC_2931 9014674 55.67 µM -1.91469251933079 0.0195983782457435 no 3281 0.0277658640793942 4611 2996810 SGTC_2292 7671323 168.05 µM -1.91528724342795 0.0195679257935366 no 3282 0.0277279407687742 4656 937504 SGTC_2708 st078559 56 µM -1.91663570069454 0.0194990277567669 no 3283 0.0276421146014529 4639 17250902 SGTC_2591 skatole 100 µM -1.93136544807418 0.018759750674807 no 3284 0.0267189374508931 4640 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3124 9127567 49.47 µM -1.93137714375232 0.0187591732872537 no 3285 0.0267182147910819 4634 17592030 SGTC_738 1315-0003 72.4 µM -1.93356028991229 0.0186516611434593 no 3286 0.0265836068185048 4658 6251474 SGTC_89 0302-0250 142.109 µM -1.94174422740865 0.0182532877224857 no 3287 0.0260840358404063 4723 4203518 YLR208W SEC13 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.97003794872735 0.0169314108816913 no 3288 0.0244170107556448 4655 5379071 SGTC_2333 9017922 200 µM -1.97607417108576 0.016660247661872 no 3289 0.0240731886431079 4645 3163164 SGTC_381 3461-2219 42.7 µM -1.98449777861853 0.0162880533528289 no 3290 0.0236001877404537 4665 2883159 SGTC_1993 st073995 70.8 µM -1.98646546457468 0.0162021451794806 no 3291 0.0234908319393681 4663 3098394 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.99757877648154 0.0157241966171492 no 3292 0.022881173041916 4732 4213774 SGTC_1766 st045414 44.774 µM -1.99997084204034 0.0156229182575804 no 3293 0.022751706260506 4686 253960 SGTC_477 mead ethanolamide 10 µM -2.00117743612604 0.0155720446439735 no 3294 0.0226866358403606 4707 16061185 SGTC_1026 k007-1105 30.6 µM -2.01530539407271 0.0149868677977531 no 3295 0.0219363300479961 4650 7066794 SGTC_1735 st034310 56.75 µM -2.02320697150683 0.0146679039122856 no 3296 0.021525906610834 4686 871153 SGTC_917 harmaline 728.087 nM -2.03735235732842 0.0141114694793888 no 3297 0.020807372271869 4616 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3 0833-0587 95.581 µM -2.04319691435613 0.0138869293518436 no 3298 0.0205164745430896 4599 5382644 SGTC_2623 humulene 100 µM -2.05328371160292 0.0135066513184097 no 3299 0.020022534832178 4669 6187145 An anti-inflammatory. SGTC_1470 k295-0292 231 µM -2.05663003456071 0.0133824947868425 no 3300 0.0198609134435278 4738 5045612 SGTC_2000 st075254 36.4 µM -2.06120481982802 0.0132143548288672 no 3301 0.0196417519555929 4636 17234175 SGTC_990 3985-0011 41.3 µM -2.06398003011021 0.013113247777628 no 3302 0.0195098049253481 4685 5399565 YGL099W LSG1 SGTC_78 0336-0123 156.75 µM -2.07097255550475 0.0128614543115349 no 3303 0.0191806804301841 4591 6765896 SGTC_2719 novobiocin 32.65 µM -2.07106036668558 0.0128583190963342 no 3304 0.0191765775233203 4706 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2907 7721985 69.9 µM -2.07740859469454 0.0126334059600227 no 3305 0.0188819318076038 4687 3267881 SGTC_593 1203-0218 61.7 µM -2.09080524264748 0.0121699227461777 no 3306 0.0182727629823135 4731 3666956 SGTC_2666 tannic acid 100 µM -2.10821142488345 0.0115897873768762 no 3307 0.0175063527416696 4691 16134267 A thiamine antagonist. SGTC_345 1362-0200 395 µM -2.11665063971249 0.0113172639787052 no 3308 0.0171447544653216 4693 1419823 SGTC_2063 5246145 200 µM -2.11895295934134 0.0112438901269985 no 3309 0.017047221304278 4690 711240 SGTC_1692 fluoroquinolonic acid 71 µM -2.12332720002579 0.0111056236938797 no 3310 0.0168632214687714 4722 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1571 st070080 73.4 µM -2.13876659094055 0.0106293488718627 no 3311 0.0162272882354542 4700 4315245 SGTC_1459 k035-0031 35.7 µM -2.14289518637123 0.0105050444056726 no 3312 0.0160607577974749 4541 3877128 YMR208W ERG12 SGTC_1671 st016596 74.5 µM -2.15538573078185 0.0101366583253384 no 3313 0.0155658310209984 4741 2829167 SGTC_688 0527-0193 473 µM -2.16585604644214 0.00983658999428023 no 3314 0.0151610944704604 4740 4007154 SGTC_691 1548-0686 185 µM -2.16826341107291 0.00976870451883903 no 3315 0.0150693253062568 4716 46495133 SGTC_1776 st049249 45.9 µM -2.16941474437917 0.0097363828949131 no 3316 0.0150256052851816 4730 1822314 SGTC_398 bronopol 33.3 µM -2.17670166498071 0.0095339744039835 no 3317 0.0147514169998312 4673 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1926 methyl fluorone black 53.6 µM -2.18373918851558 0.00934199523112538 no 3318 0.0144907091908739 4419 72721 Reacts with homocysteine. SGTC_836 0330-0104 1.35 µM -2.19803684664136 0.00896235345315053 no 3319 0.0139732401413165 4741 46494820 SGTC_126 0417-1624 672.48 µM -2.1994413760306 0.0089257987274306 no 3320 0.0139232766525762 4745 41912 YDL195W SEC31 SGTC_2407 paclitaxel 400 µM -2.2003671357976 0.00890177609834089 no 3321 0.0138904287791675 4712 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1313 1220-0047 237 µM -2.20813832355968 0.00870234466825964 no 3322 0.0136173161079414 4738 3528706 SGTC_396 dithiazanine 1.25 µM -2.2201650565251 0.00840142524599315 no 3323 0.0132037826891106 4711 10578 An antihelmenthic. SGTC_2087 5276107 200 µM -2.23912312258043 0.00794561411845731 no 3324 0.0125739530788327 4723 144405 SGTC_910 3454-3003 490 µM -2.23957129329372 0.00793510706890618 no 3325 0.012559384052985 4659 820824 SGTC_3063 1327-0034 4 µM -2.24358882575521 0.00784146321790549 no 3326 0.0124294344417467 4633 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_147 4466-0538 29.23 µM -2.24435571595842 0.00782369884567782 no 3327 0.0124047616909103 4716 6742687 YHR072W ERG7 SGTC_2546 rhodinyl acetate 100 µM -2.27316243916333 0.00718155433128546 no 3328 0.0115081964301051 4719 6708682 SGTC_3112 9123419 49.47 µM -2.30061174549844 0.00661339100057058 no 3329 0.0107067932702519 4759 17015854 SGTC_2085 5307070 144.047 µM -2.33308835488071 0.00599278158473213 no 3330 0.00982175426272006 4709 2840351 SGTC_2217 6934799 96.0675 µM -2.35610861121134 0.00558471027537204 no 3331 0.00923375860968555 4751 675606 SGTC_835 0312-0010 67.2 µM -2.36012463485477 0.0055161047985644 no 3332 0.00913439806735335 4760 1626196 SGTC_2458 5808907 16.39 µM -2.36101358494759 0.00550102051979624 no 3333 0.00911253148718797 4781 2731747 SGTC_1089 terbinafine 2.25 µM -2.37882710238422 0.00520637745229463 no 3334 0.00868391003209376 4759 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -2.4033351779416 0.00482397104088878 no 3335 0.00812314444710553 4753 94937 An inhibitor of serotonin biosynthesis. SGTC_2622 2-methoxyxanthone 59.94 µM -2.40818253665105 0.00475137267451787 no 3336 0.00801608143557273 4738 71034 A hepatoprotective. SGTC_1740 st038286 13.222 µM -2.40993963539063 0.00472529839027249 no 3337 0.00797758006996191 4726 716786 SGTC_2457 5731572 11.68 µM -2.42301130668563 0.0045352956683063 no 3338 0.00769622379740783 4769 2865357 SGTC_180 1486-1293 102.781 µM -2.44621627570408 0.00421474093404221 no 3339 0.00721821861574343 4711 4140536 SGTC_2790 5423970 71.43 µM -2.49212883328359 0.00363958166904843 no 3340 0.00634899846652519 4740 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_729 4092-0585 94.1 µM -2.50938848909514 0.00344227710732799 no 3341 0.00604701968382433 4761 2169061 SGTC_1300 1094-0077 113 µM -2.51767290851344 0.00335103119798074 no 3342 0.00590664849845913 4773 5532636 SGTC_2218 6965428 192.983 µM -2.55098755893732 0.00300565371537127 no 3343 0.00537090801042819 4724 675684 SGTC_924 2046-0044 21.3 µM -2.66276675919664 0.00206859302475419 no 3344 0.0038750556479156 4761 3623589 SGTC_3026 9090633 49.47 µM -2.66858642349337 0.00202799944401277 no 3345 0.00380855896293502 4769 25236842 SGTC_2365 9042475 200 µM -2.67663561817836 0.00197304574480157 no 3346 0.00371827313159057 4768 6464479 SGTC_2749 bexarotene 57.39 µM -2.73465590955561 0.00161526828756695 no 3347 0.00312227574942556 4761 82146 An retinoic acid receptor inhibitor. SGTC_2360 9040895 200 µM -2.73832479829637 0.00159476702138314 no 3348 0.00308765270524717 4773 4914414 SGTC_2718 lomofungin 53.02 µM -2.93033133302943 0.000800914645468703 yes 3349 0.00169300377431165 4784 5351222 A RNA synthesis inhibitor. SGTC_176 1486-1328 72.834 µM -2.95007031177954 0.000744484653021034 yes 3350 0.00158850809662803 4780 22310231 SGTC_2445 5742597 35.57 µM -2.95912286767304 0.000719850678192665 yes 3351 0.00154258033459121 4788 1774255 SGTC_2627 acetyl isogambogic acid 100 µM -3.09717321201473 0.00042619199760839 yes 3352 0.000976878385763776 4771 6857789 A caspase activator and apoptosis inducer. SGTC_925 2064-1272 59.6 µM -3.1262520046768 0.000380634952973465 yes 3353 0.000885248811500399 4781 6815817 SGTC_3100 9120536 49.47 µM -3.17830064549605 0.000310192074610456 yes 3354 0.00074070526323245 4777 16421196 SGTC_2097 5376186 200 µM -3.80950293148409 2.04701465304044e-05 yes 3355 6.96232278719069e-05 4809 742755 SGTC_2299 7976368 114.88 µM -3.81725360328234 1.97442148879752e-05 yes 3356 6.74727216652215e-05 4802 2979718