SGTCid condition conc unit PAU13|YHL046C.score PAU13|YHL046C.strain.pval PAU13|YHL046C.strain.significant PAU13|YHL046C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1908 st060353 56.5 µM 6.23762785820217 5.17164454032569e-12 yes 1 2.22127982913366e-10 7 4227716
SGTC_2497 7-hydroxyflavone 100 µM 4.6909071198544 1.55732843266802e-07 yes 2 1.35998215894807e-06 9 5281894
SGTC_1127 asiatic acid 681.4 nM 4.67788041266278 1.67881484158026e-07 yes 3 1.44927749635861e-06 10 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2489 cantharidin 73.42 µM 4.58939798794182 2.78193160395972e-07 yes 4 2.22263086804906e-06 25 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_916 4466-0038 42 nM 4.48657405261726 4.94694196022537e-07 yes 5 3.6188784186916e-06 51 5722064 YGL116W CDC20
SGTC_420 mitomycin C 81.9 mM 4.26142332254278 1.67244719524683e-06 yes 6 1.01564524604169e-05 15 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1097 itavastatin 7.23 µM 4.06287196566349 4.6663756169279e-06 yes 7 2.42363098276664e-05 20 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1912 st060209 90.8 µM 4.03844272901372 5.27787204923438e-06 yes 8 2.69036132382861e-05 35 688787
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 3.94979762326602 8.20420654066037e-06 yes 9 3.91086491054995e-05 26 2333 A French combination drug.
SGTC_912 3474-0017 2.18 µM 3.89901458982537 1.05205367915943e-05 yes 10 4.82924777479873e-05 23 3360550
SGTC_2278 7948257 134.34 µM 3.59415312797519 4.40221128272627e-05 yes 11 0.000162724200472104 35 1247028
SGTC_2493 resveratrol 26.09 µM 3.47704805993087 7.41847852835732e-05 yes 12 0.000253483467706261 16 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2160 5660466 132.927 µM 3.46850471462978 7.70170001543937e-05 yes 13 0.000261681671790101 31 2859134
SGTC_1354 1498-1681 81 µM 3.40508155018447 0.000101453407317807 yes 14 0.000330721490094641 39 5754243
SGTC_1099 5-nonyloxytryptamine 2.85 µM 3.27106453692351 0.000178935365664233 yes 15 0.000535717282599054 46 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2162 5663267 200 µM 3.25405185020009 0.000192022733856305 yes 16 0.000568857560855896 29 6456493
SGTC_1106 tegaserod maleate 11.7 µM 3.23511823069557 0.000207637084276168 yes 17 0.000607961849918511 55 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1119 parthenolide 318.541 nM 3.19605043829872 0.000243675084965745 yes 18 0.000696613771298755 81 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2751 anetholtrithion 17.25 µM 3.16318912669014 0.000278420218474543 yes 19 0.000780254587526762 60 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1065 prochlorperazine maleate 2.48 µM 3.13054764093734 0.000317456327149228 yes 20 0.00087240347971428 41 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2629 bisabolol 100 µM 3.10364837538777 0.000353390017564268 yes 21 0.000955751803183067 59 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2636 apigenin dimethyl ether 100 µM 3.09924652535448 0.000359618252971003 yes 22 0.000970067555265076 90 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1363 1636-0063 10.4 µM 3.09343968340757 0.000367990482638243 yes 23 0.000989253833898612 67 6072185
SGTC_739 1486-1183 203 µM 3.08682660464161 0.000377745460980807 yes 24 0.00101152783701853 44 4346692
SGTC_1553 gossypol 38.6 µM 3.06239762596541 0.000415900751409031 yes 25 0.00109785783802151 9 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_580 1123-0028 41 µM 3.04946177438535 0.000437524040384503 yes 26 0.00114625902643961 88 1677248 YPR107C YTH1
SGTC_493 zm226600 134 µM 3.00371719546979 0.000522628965317884 yes 27 0.00133351553779489 54 5240098 A potassium channel opener. YCR052W RSC6
SGTC_963 1269-2853 151 µM 2.99618427693393 0.000538031674321287 yes 28 0.00136690585669135 71 3668223
SGTC_959 1222-0044 107 µM 2.99159385039529 0.000547622606412999 yes 29 0.00138762609300456 61 6083612
SGTC_2713 st079149 53.4 µM 2.9879088948674 0.000555435849107633 yes 30 0.00140446636329885 64 3103253
SGTC_887 0885-0007 9.62 µM 2.95411944215194 0.000632039548782569 yes 31 0.00156781309776985 82 5719458
SGTC_247 mechlorethamine 29.705 µM 2.95197521101764 0.000637215511867719 yes 32 0.00157874138963911 45 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2354 9060492 162 µM 2.92736928791391 0.000699478586830421 yes 33 0.00170921359692629 68 6471895
SGTC_1068 loratadine 26.9 µM 2.91158101383477 0.000742334488182018 yes 34 0.00179802320311613 76 3957 A H1 histamine antagonist.
SGTC_814 3342-0569 96 µM 2.8725245524791 0.000858952374262272 yes 35 0.00203603217825978 84 4346283
SGTC_1575 cyproterone acetate 48 µM 2.7851899609096 0.00118308314106933 no 36 0.00267481862070853 82 9880 An androgen receptor antagonist and liver toxin.
SGTC_1348 1493-0373 93.8 µM 2.75520640648746 0.00131797697872774 no 37 0.00293275598432011 77 3010129
SGTC_1561 5-methoxyflavone 52.9 µM 2.73711695891085 0.00140601592548825 no 38 0.00309901263770535 34 94525
SGTC_2750 bromebric acid 70.15 µM 2.73288277503572 0.00142738401332227 no 39 0.00313913364422106 115 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_153 4077-0274 519.67 µM 2.7212320686355 0.00148771930979241 no 40 0.00325195423593558 73 3121976
SGTC_2625 euphol 100 µM 2.72048094617805 0.00149168785497037 no 41 0.00325935142630294 118 6708538 A triterpene alcohol.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.71916533656991 0.00149866214099128 no 42 0.00327234426564046 73 7104
SGTC_170 4197-0004 226 µM 2.6898315432665 0.00166209927021091 no 43 0.0035744047910674 70 218692
SGTC_171 k064-0041 9.68 µM 2.68978084878071 0.00166239525436031 no 44 0.00357494778883217 77 53325
SGTC_996 3970-0799 1.8 µM 2.68952465033954 0.00166389182563446 no 45 0.00357769310934964 194 6615648 YGL040C HEM2
SGTC_360 0957-0399 1.01 µM 2.66432818197333 0.00181721278405678 no 46 0.00385711314715329 141 6752301 YPR165W RHO1
SGTC_1041 0206-0046 107 µM 2.63824919754842 0.00198933490779628 no 47 0.00416676590402148 100 50494
SGTC_2272 7805186 180 µM 2.63470465022526 0.00201383843125391 no 48 0.00421052611736304 63 2956062 YPR165W RHO1
SGTC_550 4123-0385 25.7 µM 2.62604786240945 0.00207483882640992 no 49 0.00431913349445685 116 5731123
SGTC_1042 0350-0096 82 µM 2.61830075647391 0.00213084545381441 no 50 0.00441844403669006 94 3122515
SGTC_1340 1486-1359 257 µM 2.614516076602 0.00215870172793922 no 51 0.00446769776363282 92 4309068
SGTC_2523 spermine 47.74 µM 2.58444191323502 0.00239206258715643 no 52 0.0048768366253517 98 1103 A DNA binding polyamine.
SGTC_2491 paeonol 100 µM 2.55513391424601 0.0026412067190113 no 53 0.00530734759702575 59 11092 Increases levels of cortical cytochrome oxidase.
SGTC_442 cape 100 µM 2.55392400786864 0.00265197843763677 no 54 0.00532582504497907 77 5281787
SGTC_1676 st018489 23.4 µM 2.5483270434829 0.00270232597059139 no 55 0.00541204723663168 127 3696235
SGTC_1267 0828-0272 9.49 µM 2.54464896246527 0.00273588042667244 no 56 0.00546938218839927 103 745334
SGTC_1245 0418-0076 17.2 µM 2.5353764847666 0.00282214689830857 no 57 0.00561632663236581 115 6790114
SGTC_1152 3909-8331 15.9 µM 2.52905310475533 0.00288237577210166 no 58 0.00571853604322274 87 16001939
SGTC_2277 7947813 106.88 µM 2.52692357458989 0.00290291849785659 no 59 0.00575332696963143 128 1246798
SGTC_405 ebelactone b 50 µM 2.51783226480967 0.00299211138527749 no 60 0.00590397693202276 115 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_206 4546-0025 72.014 µM 2.50927801606289 0.00307828219455145 no 61 0.00604891134660879 177 6620745 YIL048W NEO1
SGTC_1266 0828-0227 32.9 µM 2.50914258823728 0.00307966420906542 no 62 0.0060512310333395 116 3913820
SGTC_804 1595-0054 20.9 µM 2.48590378792587 0.00332525196476735 no 63 0.00646114482222533 129 761523 Stimulates phospholipase C.
SGTC_1111 tnp00062 510.699 nM 2.46740205413233 0.00353321745780305 no 64 0.00680487245135236 102 676306
SGTC_1141 3253-0389 52.6 µM 2.4576149714257 0.00364788580584193 no 65 0.00699315171277274 71 5402031
SGTC_2805 7950783 58.44 µM 2.45187271833847 0.00371670764601532 no 66 0.00710574607392301 140 1178958 YDL195W SEC31
SGTC_34 0469-0683 81.75 µM 2.43921173661418 0.00387258212084341 no 67 0.00735967047216978 124 3690923
SGTC_672 1441-0018 53.7 µM 2.42957018505572 0.0039951853082186 no 68 0.00755836889203736 107 251141
SGTC_421 streptovitacin 30 mM 2.42896439487353 0.00400300342059498 no 69 0.00757100963860405 136 91467 include heat shock
SGTC_2237 6667747 47.222 µM 2.42406021225897 0.00406680110088566 no 70 0.00767403025220533 96 729940 YDL015C TSC13
SGTC_1218 1348-1416 30.7 µM 2.4212057008034 0.00410435258655373 no 71 0.00773456054139051 116 6787668
SGTC_2797 7859098 81.82 µM 2.42114476950797 0.00410515751742315 no 72 0.00773585716496168 143 972681
SGTC_705 1124-0212 310 µM 2.41854548381874 0.00413962712329687 no 73 0.00779134864890704 113 9554485
SGTC_2060 5238662 140 µM 2.41275691806043 0.00421732248721202 no 74 0.00791618737151274 130 790130
SGTC_769 0302-0231 76 µM 2.41155638256192 0.00423359868545762 no 75 0.00794229780247822 198 571869 YER009W NTF2
SGTC_2163 5671233 125 µM 2.35818229768665 0.00501644109316283 no 76 0.00918233599013691 154 701023
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.35094397339888 0.00513198260319437 no 77 0.00936292659421398 184 676296 Flavone; oxidizing agent.
SGTC_1717 st033143 58.0435 µM 2.3449147260454 0.00523002628287635 no 78 0.00951571586415553 192 674616
SGTC_623 k072-0108 16.9 µM 2.31298567927513 0.00577753066425797 no 79 0.0103617132579271 154 5382803
SGTC_2794 7785382 27.27 µM 2.30945952187702 0.00584101039308856 no 80 0.0104590476861768 200 2205081
SGTC_1484 3473-2379 286 µM 2.30183831609898 0.00598032926393471 no 81 0.010672145934253 148 671917
SGTC_204 PMA1.184 62.41 µM 2.29680397150109 0.00607396746715814 no 82 0.0108149774551498 161 2252213 YGL008C PMA1
SGTC_1784 st039334 36.3 µM 2.29000665016848 0.00620245742827073 no 83 0.0110104655730027 149 3496984
SGTC_1034 k072-0165 12.7 µM 2.28689028234015 0.00626216689515175 no 84 0.0111011139864445 164 5835461
SGTC_1483 3453-0561 55.9 µM 2.28481620187945 0.00630218774281494 no 85 0.0111618036189684 159 4546991
SGTC_1115 galangin 695.678 nM 2.25837335755044 0.00683262402880995 no 86 0.0119611961519123 163 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1706 st031321 9.9705 µM 2.22874772421171 0.00747340647595239 no 87 0.0129153474657104 113 6103185
SGTC_997 3996-0078 137 µM 2.22266959507362 0.00761123367634952 no 88 0.0131190437850729 185 735687
SGTC_2439 5492030 7.2 µM 2.21760462118455 0.00772779124897573 no 89 0.0132909012667806 133 5722370
SGTC_685 1278-0033 54.9 µM 2.20040957083046 0.00813529410072177 no 90 0.0138889246993683 185 3590572
SGTC_1704 st028805 70.8 µM 2.19646040807187 0.00823150885368487 no 91 0.014029502999776 129 2876101
SGTC_1158 4092-0494 91.8 µM 2.19439846088661 0.0082821408338877 no 92 0.0141033882334853 154 1148199
SGTC_1253 0550-0034 176 µM 2.18636802625859 0.00848194773679149 no 93 0.0143943454475033 162 5969915
SGTC_1248 0469-0687 58.6 µM 2.17495860428278 0.00877309886277529 no 94 0.0148166093035525 189 4017482
SGTC_823 0417-1665 178 µM 2.16362798478867 0.00907087279628242 no 95 0.0152464559982429 192 3429856
SGTC_986 1493-0483 84 µM 2.16254096411467 0.00909990019066218 no 96 0.0152882515673786 149 40079
SGTC_1367 1812-0510 76.9 µM 2.15721370303144 0.00924333647226222 no 97 0.0154945086304178 187 1142582 YDR527W RBA50
SGTC_985 1493-0307 8.71 µM 2.15456012078662 0.00931551949655089 no 98 0.0155981362761805 128 3278274
SGTC_918 glabranin 770.725 nM 2.14262757737638 0.00964623889011466 no 99 0.0160715074695388 197 124049 Also referred to as licorice root.
SGTC_1973 st070275 50.2 µM 2.1340711934393 0.00988965944895045 no 100 0.0164184767545807 152 17118334
SGTC_763 3453-1109 128 µM 2.12994134239908 0.0100090568108301 no 101 0.0165882281930949 188 1560353
SGTC_2309 7664088 163.95 µM 2.11892856675377 0.0103336158076388 no 102 0.0170482521564237 241 704922
SGTC_2565 isoliquiritigenin 100 µM 2.11868135697681 0.0103410054537323 no 103 0.0170587024651177 180 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2514 salinomycin 42.74 µM 2.11801328791868 0.0103609985664243 no 104 0.0170869711709273 255 23682228 A polyether potassium ionophore.
SGTC_1798 st045719 60.953 µM 2.11569410243581 0.0104306659453241 no 105 0.0171854162462373 133 3980186
SGTC_2496 diffractaic acid 79.83 µM 2.11347030117721 0.0104978511121635 no 106 0.0172802671786988 204 94870 An apoptosis inducer which activates caspases.
SGTC_271 rotenone 740 µM 2.09998394940325 0.0109134322985482 no 107 0.0178651265376772 217 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2089 5281248 129.67 µM 2.07373427522999 0.011763510677128 no 108 0.0190519980719877 209 2737878
SGTC_1971 st069429 63.5 µM 2.06784149070148 0.0119620570627991 no 109 0.0193274653687216 162 1246522 YGL099W LSG1
SGTC_1734 st037168 69.4 µM 2.03309004620312 0.0131930535938874 no 110 0.0210217132247786 227 708907
SGTC_2462 5162487 171.77 µM 2.02678297421391 0.0134278312752084 no 111 0.0213423062043547 200 2259986
SGTC_2585 alliin 100 µM 2.01498206820855 0.0138768143830889 no 112 0.0219532639903927 239 87310 A garlic compound which reacts with lipids.
SGTC_3024 9090631 49.47 µM 2.01107693209431 0.0140282146130927 no 113 0.0221586656628915 147 25236383
SGTC_1078 idebenone 36.1 µM 2.0092926191207 0.0140978640981428 no 114 0.0222530551012911 297 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3217 9129673 49.47 µM 2.00680029682059 0.0141956489715879 no 115 0.0223854656308026 249 17248312
SGTC_1689 st020265 53.493 µM 2.00125670001541 0.0144152461878839 no 116 0.0226823667138227 198 5758320 YPR016C TIF6
SGTC_150 3970-0969 77.2 µM 1.99820339684571 0.014537440415856 no 117 0.0228473067166329 312 6615640
SGTC_1503 4585-0012 61.3 µM 1.99432632250082 0.0146938861087337 no 118 0.0230582022176159 196 2922052
SGTC_1559 coumarin 343 70.1 µM 1.98072511714485 0.0152542204429181 no 119 0.0238110542170375 183 108770 A hepatotoxic, DNA x-linker.
SGTC_1523 st012844 44.7 µM 1.97909315757539 0.0153226704868361 no 120 0.0239027593594489 233 4274103
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.9743902849256 0.0155214024535821 no 121 0.0241686909328911 184 6857784
SGTC_551 k048-0028 34.9 µM 1.97348708964204 0.0155598214709766 no 122 0.0242200470156174 239 6836383
SGTC_276 colchicine 750 µM 1.9669128048288 0.015841937117685 no 123 0.0245966320278285 244 2833 A microtubule depolymerizer.
SGTC_2483 5729050 27.16 µM 1.94085588014776 0.017003642051338 no 124 0.0261378803981121 301 2865180
SGTC_1320 1313-0481 95.3 µM 1.93507173813719 0.0172711735243642 no 125 0.0264907465321587 219 6813365 YLR208W SEC13
SGTC_2094 5332512 191.667 µM 1.91995847869129 0.0179872287381973 no 126 0.0274315721514513 265 755774
SGTC_3327 9140648 26.9345 µM 1.91929121748447 0.0180194181016834 no 127 0.0274737444393971 215 8029710
SGTC_2834 9001755 58.44 µM 1.91562409759905 0.0181972017004593 no 128 0.02770648000394 236 2989575
SGTC_3341 9147222 25.867 µM 1.91523029575682 0.0182163819697639 no 129 0.0277315702371543 228 1939759
SGTC_3238 9133470 49.47 µM 1.91445497964443 0.0182541943885248 no 130 0.0277810231619649 197 3534688
SGTC_993 3909-8757 62.7 µM 1.9126794195079 0.0183410410595088 no 131 0.0278945527311893 207 4288324 YLR208W SEC13
SGTC_549 1661-1316 519 µM 1.91058801954691 0.0184437874123421 no 132 0.0280287725869714 248 2857282
SGTC_1086 cerivastatin 2.18 µM 1.90553784058374 0.0186939155942663 no 133 0.0283550967199545 191 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2305 7443522 69.23 µM 1.90273100507856 0.0188341782670948 no 134 0.0285378270302497 243 5415886
SGTC_2981 9013952 38.96 µM 1.87419522785186 0.0203116943060314 no 135 0.0304517608248753 267 2996344
SGTC_2760 etidronate 98.04 µM 1.86788972932119 0.0206511122042465 no 136 0.0308887213876852 280 3305 A chelator and antioxidant.
SGTC_855 0428-0020 25 µM 1.86312868965927 0.0209105657915159 no 137 0.0312220813398488 227 6812414
SGTC_1694 st024011 44.9 µM 1.85505918768572 0.0213566154668543 no 138 0.0317938874928863 284 2787533
SGTC_2602 kawain 100 µM 1.85133269372603 0.0215653011071084 no 139 0.0320608527138697 304 5369129
SGTC_533 1222-0222 6.71 µM 1.84879384040851 0.0217084631038557 no 140 0.032243793564443 287 3982874
SGTC_1583 clindamycin 39.6 µM 1.84133109056008 0.0221339325437619 no 141 0.0327865271324191 250 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_67 0335-0847 266 µM 1.83058104698119 0.0227591738718157 no 142 0.0335815497994899 443 4552207 YOR254C SEC63
SGTC_2787 5284540 71.43 µM 1.82827065179321 0.0228954762094794 no 143 0.0337544710662516 279 736958
SGTC_712 r015-0009 80.6 µM 1.8249842920199 0.0230905401286841 no 144 0.0340016998942774 241 6813872 YLR060W FRS1
SGTC_1716 st033144 30.6155 µM 1.8247933847227 0.0231019144279141 no 145 0.0340161072629546 290 674617
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.82447649757558 0.0231208050497294 no 146 0.0340400331461067 328 6728940
SGTC_1128 3448-9350 235 µM 1.82074215674394 0.0233444020965268 no 147 0.0343230303547229 273 619386
SGTC_1652 st011932 78 µM 1.81419609429886 0.0237407443561649 no 148 0.0348237706341661 250 1551076
SGTC_972 1319-0219 195 µM 1.81332129153857 0.0237941368643627 no 149 0.0348911406254682 280 23903702
SGTC_183 3914-0051 30.55 µM 1.80393022015531 0.0243736947678447 no 150 0.0356211233830074 281 1596232
SGTC_3284 9108171 64.8615 µM 1.80127282166423 0.024539828024552 no 151 0.0358299446949303 240 8687505
SGTC_409 arachidonic acid 100 µM 1.80007611715197 0.0246149524760337 no 152 0.0359243100633961 276 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2533 agelasine 13.65 µM 1.79740607181236 0.0247832633504874 no 153 0.0361355887603801 323 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2432 5630864 12.22 µM 1.79401979323064 0.0249981107022252 no 154 0.0364050048256041 297 5714970
SGTC_2301 7769476 200 µM 1.79177062622206 0.0251416736544438 no 155 0.0365848579469522 254 977820
SGTC_1773 st048542 73.5835 µM 1.78906680316164 0.0253151710346789 no 156 0.0368020288359393 326 3237138
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.78286349388332 0.025717014678826 no 157 0.0373042634679743 253 229346 A bile salt which induces apoptosis.
SGTC_2798 7813637 45.45 µM 1.78236268108076 0.0257496884214387 no 158 0.0373450535581228 304 956368
SGTC_2115 tiliquinol 12.7705 µM 1.78060818825097 0.0258644282311907 no 159 0.0374882405879932 244 71208 A bioactive hydroxyquinoline.
SGTC_1182 1222-0449 220 µM 1.77991871881799 0.0259096348941505 no 160 0.0375446318880258 262 658318
SGTC_1673 st016611 27.3 µM 1.77846707626006 0.0260050313489691 no 161 0.0376635873276997 332 5226799
SGTC_1118 chelidonine 707.474 nM 1.77709031430399 0.0260957782247212 no 162 0.0377766907571679 308 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_591 4299-0174 154 µM 1.77531715412087 0.0262130430501213 no 163 0.0379227672698907 257 5509088
SGTC_396 dithiazanine 1.25 µM 1.76405424424619 0.0269682258516675 no 164 0.0388614234826018 241 10578 An antihelmenthic.
SGTC_2139 5578692 56.4705 µM 1.76281922050942 0.0270521286865214 no 165 0.038965492313445 251 650991 YMR113W FOL3
SGTC_2978 9011784 42.97 µM 1.75838349534054 0.0273552733575741 no 166 0.0393411397404155 372 2994934
SGTC_1767 st044992 70.3 µM 1.75322403518349 0.0277114381276677 no 167 0.0397817794595947 338 9600693
SGTC_2033 5192550 145 µM 1.75153665313308 0.0278287557831271 no 168 0.039926756704936 274 182073
SGTC_268 camptothecin 39.6153 µM 1.75113135353431 0.0278569963667547 no 169 0.0399616432989246 431 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_106 0092-0003 11.579 µM 1.74924890546619 0.0279884752723134 no 170 0.0401240018875988 224 1072148
SGTC_2763 lisinopril 49.32 µM 1.74831037615311 0.0280542193376949 no 171 0.0402051487408107 244 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.74527952479683 0.0282674095405326 no 172 0.0404681121219145 286 4213774
SGTC_1650 st011916 45.8 µM 1.73054400610998 0.0293232100399509 no 173 0.0417665629841128 263 242528
SGTC_974 1326-0144 138 µM 1.72645511307573 0.0296219169805924 no 174 0.0421327840105 353 5411856
SGTC_867 0518-0118 155 µM 1.7201534324402 0.030087217119663 no 175 0.0427022776203196 312 6848158
SGTC_1755 st041960 45.185 µM 1.71496159808458 0.0304751072943283 no 176 0.043176133915919 304 2257073
SGTC_2848 9016370 25.97 µM 1.71375539149745 0.0305658154815729 no 177 0.0432868295856804 354 7894410
SGTC_664 1222-0054 14.9 µM 1.70708670935569 0.0310713528152951 no 178 0.0439029685252349 334 6813991
SGTC_1063 disulfiram 1.84 µM 1.70459660917701 0.0312618867844333 no 179 0.0441348421026115 333 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2179 6298986 200 µM 1.70329239240617 0.0313620659714534 no 180 0.0442566817890203 274 738374
SGTC_68 0986-0284 82.829 µM 1.70211195222779 0.0314529663748038 no 181 0.0443671918883773 350 423278 YIL048W NEO1
SGTC_80 0159-0065 512.242 µM 1.69633653847297 0.031900850217194 no 182 0.0449110822854285 195 1548079
SGTC_2928 9011484 9.79 µM 1.69454654070414 0.0320407293558517 no 183 0.0450807378621047 296 2994751
SGTC_1772 st048439 82.2 µM 1.69351285976473 0.032121736629279 no 184 0.0451789445851316 360 2927068 YDL195W SEC31
SGTC_1974 st069448 26.9 µM 1.69091276091577 0.0323262483689342 no 185 0.0454267328562737 289 6323587 YNR016C ACC1
SGTC_585 0kpi-0023 191 µM 1.68887668677045 0.032487145653892 no 186 0.04562153190204 301 64601
SGTC_1792 st045773 43.6 µM 1.68848905331522 0.0325178524627231 no 187 0.045658694274289 336 2919270
SGTC_866 0495-0101 262 µM 1.68652056988616 0.0326741577454635 no 188 0.0458477882680303 295 635694
SGTC_537 1334-0398 209 µM 1.68290296265674 0.0329630253420816 no 189 0.0461969389915082 339 5846986
SGTC_938 3126-1755 342 µM 1.68133724232566 0.033088699777461 no 190 0.0463487139528947 319 1777771
SGTC_3315 9136395 68.55 µM 1.67706197963072 0.0334338707913406 no 191 0.0467651812809487 339 16876844
SGTC_1741 st038134 10.228 µM 1.67647179213541 0.0334817526860571 no 192 0.0468229084640411 385 1272587
SGTC_2882 9058044 58.44 µM 1.67580459399261 0.0335359504212231 no 193 0.0468882370005254 309 18076804
SGTC_1044 1222-0021 1.78 µM 1.67499896955764 0.033601489004252 no 194 0.0469672169189353 359 4306703
SGTC_3209 9113616 49.47 µM 1.67483454424931 0.0336148781592849 no 195 0.0469833495631778 370 16649353
SGTC_927 2425-1185 123 µM 1.66987515445843 0.0340207893712406 no 196 0.0474720334944541 329 730375
SGTC_2167 5876490 200 µM 1.66865453173126 0.0341213094151889 no 197 0.0475929324911687 351 686534
SGTC_3354 9151612 71.43 µM 1.66642473663328 0.0343055667056995 no 198 0.0478144236327507 344 27261949
SGTC_2350 9023895 38.85 µM 1.66409093902202 0.0344992932271415 no 199 0.0480471287665144 337 2997209
SGTC_3309 9129340 25.759 µM 1.66200670762153 0.0346730623624285 no 200 0.0482557147872076 345 17158987
SGTC_269 exalamide 29 µM 1.66118367962731 0.0347418785512484 no 201 0.0483382811557995 304 3316 A derivative of salicylamide.
SGTC_1459 k035-0031 35.7 µM 1.65737434204776 0.0350618526341625 no 202 0.0487219077614104 278 3877128 YMR208W ERG12
SGTC_2701 st077767 14.721 µM 1.6564329836551 0.0351412957464101 no 203 0.0488170830741247 391 5721188
SGTC_1195 1502-0147 41.1 µM 1.65371988008858 0.0353710865228637 no 204 0.0490922207160856 374 817940
SGTC_3333 9141820 12.094 µM 1.64536648359863 0.0360863399360324 no 205 0.04994712850724 310 1939433
SGTC_1140 3229-1848 2.98 µM 1.64424232928271 0.0361834928267113 no 206 0.0500630782797388 299 2849525
SGTC_3189 9110682 49.47 µM 1.63739691759286 0.0367797266691157 no 207 0.0507737809330103 349 17122418
SGTC_1646 st011709 75.6 µM 1.63599758807749 0.0369025916904488 no 208 0.0509200460929349 297 5757843
SGTC_2879 9041815 71.43 µM 1.63276473806657 0.0371877283531641 no 209 0.0512592429658733 222 4942971
SGTC_737 1950-0117 57.9 µM 1.62568653596128 0.0378183119712787 no 210 0.0520081778530384 353 5393513
SGTC_248 streptozotocin 5.23457 mM 1.62276966497057 0.0380806969584353 no 211 0.0523193263649723 373 5300 DNA alkylating agent.
SGTC_495 decylubiquinone 155 µM 1.62135973593706 0.0382080574110049 no 212 0.0524702553316726 355 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_314 1671-0008 2.74 µM 1.61818232612973 0.0384963500351573 no 213 0.0528116552841607 420 3913060
SGTC_2819 7996655 46.38 µM 1.60633205866626 0.0395872214313112 no 214 0.0541004850337846 325 6456960
SGTC_1428 4049-0204 61.7 µM 1.60594422433413 0.0396233438994183 no 215 0.0541430827176015 364 X1428
SGTC_3216 9129716 49.47 µM 1.60192732298287 0.039999052440542 no 216 0.0545858408379977 352 8056934
SGTC_861 0443-0273 110 µM 1.60157222242164 0.0400324044891457 no 217 0.0546251187108395 338 6149169
SGTC_147 4466-0538 29.23 µM 1.60085328925406 0.0400999979133315 no 218 0.0547047087347496 406 6742687 YHR072W ERG7
SGTC_33 0986-0033 35.816 µM 1.60037018159488 0.0401454713129094 no 219 0.0547582430065854 321 2848082
SGTC_465 cgp-37157 41 µM 1.59782996254624 0.0403852638301627 no 220 0.0550404122263667 239 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_917 harmaline 728.087 nM 1.58769932023119 0.0413531727039356 no 221 0.0561771734202396 391 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1867 st057372 64 µM 1.58732899195921 0.0413889080181698 no 222 0.056219076138989 361 688837
SGTC_674 0498-0004 451 µM 1.57887252003631 0.0422117593052016 no 223 0.0571826501389351 390 4231473
SGTC_2136 5328288 199.296 µM 1.57534791795124 0.0425586039580272 no 224 0.0575880795340941 318 262395
SGTC_1814 st052110 31.539 µM 1.57012550328179 0.0430767582613132 no 225 0.0581929582177812 349 674163
SGTC_2806 7952793 58.44 µM 1.56598432308101 0.0434912480678835 no 226 0.0586761436524379 391 2972490
SGTC_2898 9056270 58.44 µM 1.56209449617001 0.0438835063922906 no 227 0.0591328646431596 314 19154699
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.55746526059053 0.044354041725131 no 228 0.0596800311431079 282 77254
SGTC_784 4579-0127 173 µM 1.55702847986449 0.0443986471069362 no 229 0.0597318619069121 404 1948547
SGTC_2977 9011197 71.43 µM 1.54978522849067 0.0451436335438056 no 230 0.0605965368066646 320 2704722
SGTC_545 4218-0007 221 µM 1.54683087529088 0.0454503698374719 no 231 0.0609520164856159 378 2840508
SGTC_2913 7966556 36.57 µM 1.5430332878259 0.0458471146226197 no 232 0.061411349743331 354 2976516
SGTC_2856 9022925 19.48 µM 1.52915087274693 0.0473211868948019 no 233 0.0631135231032497 409 4944862
SGTC_1383 3049-0032 20.7 µM 1.52672698428236 0.047582414735946 no 234 0.0634144572448187 422 712864
SGTC_2358 9037157 4 µM 1.52611628167761 0.0476484133598062 no 235 0.0634904539580242 401 2388925
SGTC_2490 carminic acid 95.39 µM 1.52459566072572 0.047813065429172 no 236 0.0636799901942774 321 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1315 1237-0019 3.69 µM 1.52433615007273 0.0478412105642023 no 237 0.0637123805616696 408 825140
SGTC_2479 5617353 43.85 µM 1.51150701890837 0.0492492040703155 no 238 0.065329660841401 421 2731746
SGTC_357 1325-0123 420 µM 1.50987004010381 0.0494312184230648 no 239 0.0655382943828791 383 1098503
SGTC_2218 6965428 192.983 µM 1.50920244324888 0.0495056019580859 no 240 0.0656235280183824 394 675684
SGTC_207 4185-0010 4.486 µM 1.50741880814092 0.0497047725457804 no 241 0.0658516704012571 502 3761753
SGTC_2097 5376186 200 µM 1.50511345576818 0.049963147572889 no 242 0.066147455074574 440 742755
SGTC_1969 st069479 40.1 µM 1.50508268503523 0.0499666034679972 no 243 0.0661514100143565 366 3895485
SGTC_715 0868-0130 184 µM 1.50177205605063 0.0503395388129869 no 244 0.0665779937112675 372 2876258
SGTC_1451 4152-0210 104 µM 1.49208247705383 0.051443807520749 no 245 0.0678387624913613 437 659563
SGTC_151 3013-0144 2.285 µM 1.49195570027398 0.0514583822441886 no 246 0.067855379534905 442 906558 YHR107C CDC12
SGTC_435 c-PAF 6.7 µM 1.49110646435487 0.0515560982140726 no 247 0.0679667727082845 438 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2693 st077581 40.7 µM 1.49097649381971 0.0515710660751658 no 248 0.0679838332260896 530 25238761
SGTC_358 0075-0058 9.45 µM 1.48892412275405 0.0518078826694215 no 249 0.0682536752635884 545 1069125
SGTC_1916 st067606 49.2 µM 1.48702755020871 0.0520274897741633 no 250 0.0685037673551789 468 19590279
SGTC_1496 4469-0713 57.4 µM 1.48152070524111 0.0526693290424634 no 251 0.0692339358196806 421 746691
SGTC_1304 1165-0502 251 µM 1.48021391991291 0.0528225574603256 no 252 0.0694080833830825 503 767425
SGTC_2644 guaiazulene 100 µM 1.46327765395839 0.0548405900142109 no 253 0.071695709864199 394 3515 A coloring agent.
SGTC_2212 7123476 200 µM 1.46284867222037 0.0548924855753159 no 254 0.0717543957302611 336 1085715
SGTC_2447 5741742 33.78 µM 1.45607443738224 0.0557171468985985 no 255 0.0726860216056929 457 1776504
SGTC_1204 4049-0315 18.3 µM 1.45605844709441 0.0557191049783477 no 256 0.07268823157417 448 588402
SGTC_924 2046-0044 21.3 µM 1.45082448674376 0.0563629492398207 no 257 0.0734143696584433 441 3623589
SGTC_3226 9131256 49.47 µM 1.45055705948827 0.0563960030385965 no 258 0.0734516198541158 289 17178073
SGTC_923 1900-2434 73.3 µM 1.44179277986243 0.0574877401385083 no 259 0.0746804201671518 450 5910570
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.44164848067145 0.0575058531430829 no 260 0.0747007821818209 535 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_249 wiskostatin 11.211 µM 1.43822995563372 0.0579362742281022 no 261 0.0751844091946642 445 2775510 A n-wasp and actin depolymerizer.
SGTC_3255 9139072 49.47 µM 1.43468803538102 0.0583848986280109 no 262 0.0756880075836121 448 17646060
SGTC_2752 diclazuril 33.15 µM 1.42814309072893 0.0592210642385341 no 263 0.07662533842313 644 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_535 2293-4129 48.2 µM 1.42664748300004 0.0594134512072894 no 264 0.0768407651466929 554 396118 YIL048W NEO1
SGTC_1007 4101-0031 70 µM 1.42655783452812 0.0594249986527196 no 265 0.0768536926883691 483 1146276
SGTC_2996 9066192 71.4286 µM 1.42475333050662 0.0596578076284875 no 266 0.0771142585715174 485 6472854
SGTC_1968 st069590 43.6 µM 1.42413214694331 0.0597381150859582 no 267 0.0772041110822755 454 6384066
SGTC_505 gw-5074 63.9 µM 1.4235201797978 0.0598173138298117 no 268 0.0772927082250358 475 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3210 9128157 49.47 µM 1.42197958915227 0.0600170561039179 no 269 0.0775160881696419 469 17590849
SGTC_1832 st054113 55 µM 1.41770503564199 0.0605740005678446 no 270 0.0781384496475361 427 1251267
SGTC_747 3448-8087 38.7 µM 1.41520284389152 0.060901889913245 no 271 0.0785045154753145 502 5168703
SGTC_3194 9111903 49.47 µM 1.41516631139615 0.0609066874204543 no 272 0.0785098697214761 479 17087251
SGTC_1212 0520-0165 585 µM 1.41446727106868 0.0609985434735656 no 273 0.0786123752408289 479 5403258
SGTC_592 k241-0073 46.5 µM 1.40731759438311 0.0619442620685272 no 274 0.0796666171986088 491 4230158
SGTC_848 0368-0089 85.6 µM 1.40624433432639 0.0620872092955713 no 275 0.0798257917249754 488 762535
SGTC_2156 5649887 115 µM 1.40598781724836 0.062121412816848 no 276 0.0798638712030416 545 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2584 androsterone 48.74 µM 1.40327407384945 0.0624841594102147 no 277 0.0802675631209004 642 2754130 A steroid.
SGTC_1066 ketoconazole 628 nM 1.39757979297675 0.0632506814976557 no 278 0.0811196449467455 522 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3055 9094636 49.47 µM 1.39669659292955 0.0633702244487863 no 279 0.0812524145953966 441 25236176
SGTC_541 4513-1321 94 µM 1.3893422914771 0.0643724850176491 no 280 0.0823643447427956 491 747515
SGTC_1786 berberine 21.6 µM 1.38836470341934 0.0645066352967877 no 281 0.0825130093570162 497 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1860 st056228 74.6 µM 1.38822494278065 0.0645258317903585 no 282 0.0825342796508879 465 688679
SGTC_1570 verbenone 133 µM 1.38439665669805 0.0650533845392108 no 283 0.0831185160517977 493 29025 A natural terpanoid with antifungal properties.
SGTC_64 000l-0018 272.079 µM 1.382729001294 0.0652842380800355 no 284 0.0833739879691606 622 6811119
SGTC_1733 st037357 54.9 µM 1.37919579193347 0.0657754394968226 no 285 0.0839171975817651 523 1272339 YGL099W LSG1
SGTC_2829 7992743 58.44 µM 1.37535705487379 0.0663123585062644 no 286 0.0845103880519429 496 16462845
SGTC_321 4534-3890 65.3 µM 1.37336111701129 0.0665928655890722 no 287 0.0848200556603115 487 699746
SGTC_350 k064-0020 19.8 µM 1.37172618428603 0.066823320921036 no 288 0.0850743469614156 531 2790705
SGTC_417 st075190 100 µM 1.37165060350879 0.0668339894694945 no 289 0.0850861163141105 523 222757
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.37138197099804 0.0668719187577109 no 290 0.085127957339251 496 688669
SGTC_1155 4088-0394 48.2 µM 1.37046303324544 0.0670017931450265 no 291 0.0852712036541857 510 2326248
SGTC_1426 4048-4480 71.7 µM 1.36944388672615 0.0671460582077884 no 292 0.0854302818809864 518 14224343
SGTC_1006 4099-6547 255 µM 1.36426077269518 0.0678834726885384 no 293 0.086242753604693 505 3146833
SGTC_2341 7987486 176.74 µM 1.36390837792176 0.0679338349348823 no 294 0.0862982018555914 539 1258686
SGTC_667 1498-1044 59 µM 1.36210999171179 0.0681912994541601 no 295 0.0865815877505316 501 6739982
SGTC_135 0933-0004 26.348 µM 1.35963142642372 0.06854737473572 no 296 0.0869732940411602 503 21230617 YGL099W LSG1
SGTC_2260 7964312 200 µM 1.35763712943623 0.0688349189997134 no 297 0.0872894276498029 451 231951
SGTC_458 nppb 133 µM 1.35554825466563 0.069137096010847 no 298 0.0876214726711602 470 4549 A chloride channel blocker.
SGTC_2845 9003024 42.97 µM 1.35081467180348 0.0698256387715126 no 299 0.0883774035012389 526 2990173
SGTC_787 4152-0075 138 µM 1.34995392104081 0.0699514079671551 no 300 0.0885153819640619 501 9566539
SGTC_21 0849-0113 22.993 µM 1.34949710055298 0.0700182273761404 no 301 0.088588675506317 528 1560156
SGTC_654 1124-0271 80.9 µM 1.34785869447372 0.070258281976251 no 302 0.0888519177450521 544 5403748
SGTC_2886 9058944 51.95 µM 1.34657658028497 0.0704465747524392 no 303 0.0890583205339646 314 4949929
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.34493298833592 0.0706885217220025 no 304 0.089323437981744 495 5282362
SGTC_1009 4106-0057 9.87 µM 1.34388744280916 0.0708427645246802 no 305 0.0894923936146148 534 2928005
SGTC_1470 k295-0292 231 µM 1.34161889956124 0.0711783175373876 no 306 0.0898597975055121 536 5045612
SGTC_1744 st037937 38.9 µM 1.34134570539333 0.071218809418954 no 307 0.0899041184284006 517 1016152
SGTC_569 4130-2812 160 µM 1.33973190671009 0.0714583618844358 no 308 0.0901662602123495 390 743552
SGTC_3150 9097574 49.47 µM 1.33934589493469 0.0715157530590705 no 309 0.0902290471538227 477 17217476
SGTC_1031 k035-0009 16 µM 1.33543955542012 0.0720985286204254 no 310 0.0908662629364722 586 5180959
SGTC_2379 9035213 200 µM 1.33450501981712 0.0722384874684879 no 311 0.0910192014113471 567 646551
SGTC_576 1073-0113 22.7 µM 1.33128229725904 0.0727227294426168 no 312 0.0915480704549611 704 5439563
SGTC_1475 4092-1048 11.7 µM 1.32882874485174 0.0730930605322777 no 313 0.091952238211476 563 2881759
SGTC_2448 5185112 27.17 µM 1.32723039380991 0.0733350855302367 no 314 0.0922162405754414 480 5718189
SGTC_2876 9059903 25.97 µM 1.31912971767447 0.0745711392988601 no 315 0.0935628748121848 550 6916095
SGTC_1921 5740136 50 µM 1.31661795801222 0.074957611911061 no 316 0.0939833581195 585 1774243
SGTC_1023 4482-3888 16 µM 1.31647489164213 0.0749796707604922 no 317 0.0940073501778184 513 3303168
SGTC_1392 3455-1037 33.9 µM 1.31385051512521 0.0753851921958959 no 318 0.0944482571198801 542 981132
SGTC_2919 7978188 46.38 µM 1.31243469476251 0.0756046593269387 no 319 0.0946867535114542 557 2980291
SGTC_1450 4112-4260 37.6 µM 1.30975895013325 0.0760207569219449 no 320 0.0951386970372218 559 1633175
SGTC_1520 flindersine 88 µM 1.30574715349867 0.0766478838361116 no 321 0.0958192784007748 560 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2346 9031566 143.75 µM 1.30551264078784 0.076684664388284 no 322 0.0958591728239713 518 4771086
SGTC_232 clozapine 119 µM 1.2969960306649 0.0780295076384167 no 323 0.0973162762752183 539 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2716 st080858 38.6235 µM 1.29628306127192 0.0781428980468174 no 324 0.0974389910695353 524 5296050
SGTC_3277 9138724 49.47 µM 1.295219576395 0.0783122665237521 no 325 0.0976222467196473 439 15943418
SGTC_1299 1079-1439 3.74 µM 1.29512846307602 0.0783267899852168 no 326 0.0976379587642715 539 323161
SGTC_1184 1269-1718 139 µM 1.29080678463218 0.0790180138754721 no 327 0.0983853422983286 558 5403821
SGTC_703 3875-0075 71.8 µM 1.28938833606522 0.0792458894859372 no 328 0.098631557180576 579 2850814
SGTC_2814 7977482 42.97 µM 1.2869727270943 0.0796351048028939 no 329 0.0990518971279158 631 6456762
SGTC_3249 9135183 49.47 µM 1.28386818066596 0.0801374469297204 no 330 0.0995940411898217 590 4902779
SGTC_352 k048-0007 5.11 µM 1.28351158132878 0.080195300776915 no 331 0.0996564523720471 623 6811911
SGTC_1976 st070609 63.5 µM 1.28004108823055 0.080759995146486 no 332 0.100265342884682 582 682556
SGTC_2765 myclobutanil 7.74 µM 1.27572451564925 0.0814665410058984 no 333 0.101026459596785 572 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_801 0866-0028 10.1 µM 1.26871784364296 0.0826233183205105 no 334 0.102270858003842 606 6849771
SGTC_2456 5770359 74.46 µM 1.26634936764842 0.0830171284427366 no 335 0.102694014837246 564 3118787
SGTC_82 0054-0107 293.755 µM 1.26516959079503 0.083213817735638 no 336 0.102905270392803 552 3104697
SGTC_758 0868-0029 16 µM 1.26417925790521 0.083379193764686 no 337 0.103082846968886 569 762687
SGTC_2907 7721985 69.9 µM 1.25810931322453 0.084398217257871 no 338 0.104176112819969 564 3267881
SGTC_1352 1496-0991 99 µM 1.25761230725032 0.0844820668162638 no 339 0.104266000115202 569 3000039
SGTC_3350 9150499 3.57 µM 1.25695583615299 0.0845929154058893 no 340 0.104384814029777 637 4910996 YPR165W RHO1
SGTC_1877 wortmannin 25 µM 1.25636604785642 0.0846925972584472 no 341 0.104491642745773 638 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2709 st078560 56 µM 1.25630601090094 0.0847027492185819 no 342 0.104502521716719 567 17250903
SGTC_1813 st051246 8.6015 µM 1.25468942316018 0.0849764496607609 no 343 0.10479576340531 532 5291959
SGTC_2190 6049624 200 µM 1.25423154415863 0.085054092360367 no 344 0.10487892876238 503 2265554
SGTC_600 1495-0418 41.6 µM 1.2530981143043 0.0852465171427425 no 345 0.10508500111414 551 5377768
SGTC_1056 3448-1962 115 µM 1.24542493076405 0.0865577963391146 no 346 0.10648779693417 564 715507
SGTC_5 0352-0601 109.883 µM 1.24372807464838 0.0868497992709297 no 347 0.10679982984675 523 762456
SGTC_522 1273-0010 11.6 µM 1.24015233487354 0.087467537867218 no 348 0.107459527338035 562 5705015
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.23829786607995 0.087789201242735 no 349 0.107802817378242 666 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_25 0118-0223 35.662 µM 1.23661059578948 0.0880826294079165 no 350 0.108115842150594 568 5333628
SGTC_3125 9127534 49.47 µM 1.23386549937034 0.0885615825654737 no 351 0.108626513684889 485 1639235
SGTC_1795 st049545 62.3 µM 1.23363061182689 0.0886026547088239 no 352 0.108670290362316 564 5291882
SGTC_2820 7989630 71.43 µM 1.22702009371899 0.0897643877677099 no 353 0.109907519358531 484 2984098
SGTC_1288 0973-0013 65.5 µM 1.22612518546469 0.0899225252546063 no 354 0.110075784753919 624 4315430
SGTC_1472 k841-0093 193 µM 1.22518834942155 0.0900882934385989 no 355 0.110252131554779 645 X1472
SGTC_808 0711-0032 135 µM 1.22260528875609 0.0905465282197532 no 356 0.110739407298923 591 4252555
SGTC_554 4483-2211 187 µM 1.2223550222404 0.0905910172606047 no 357 0.110786700143924 584 747107
SGTC_3270 9137563 49.47 µM 1.21335863340346 0.0922010693698516 no 358 0.112496367334419 550 17015724
SGTC_1664 st014217 9.02 µM 1.21212167895757 0.0924240889103855 no 359 0.112732903164778 655 3982782
SGTC_3048 9093155 49.47 µM 1.21105196016441 0.0926172779627472 no 360 0.11293774563816 542 25236002
SGTC_1321 1326-2144 215 µM 1.21079402494099 0.092663905206216 no 361 0.112987177871222 577 3513030
SGTC_3186 9110464 49.47 µM 1.21064470558465 0.0926909057695615 no 362 0.113015801372973 614 17018021
SGTC_491 tetrandrine 80.3 µM 1.20900274100188 0.0929881966983071 no 363 0.113330896164291 567 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1548 st061468 90.8 µM 1.20857384610431 0.093065967555425 no 364 0.113413304681513 625 390799
SGTC_571 k831-0106 44.2 µM 1.20368557556424 0.0939557489992915 no 365 0.114355564758794 578 4783639
SGTC_2946 9065502 71.43 µM 1.20017606608417 0.0945984239979812 no 366 0.115035484255104 450 16489101
SGTC_1710 st031758 61.5 µM 1.1993613716617 0.0947480763628691 no 367 0.115193730461851 587 5394341
SGTC_2690 usnic acid 100 µM 1.19870515203002 0.0948687450791795 no 368 0.115321307018722 694 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1873 rapamycin 2 nM 1.19766048452795 0.0950610769479315 no 369 0.115524609390615 656 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_612 0302-0167 22.4 µM 1.19563687686631 0.095434456461004 no 370 0.115919147081469 695 235821
SGTC_1319 1306-0155 43.7 µM 1.19131601337324 0.0962353180108482 no 371 0.116764774896894 691 3122360
SGTC_1997 st073024 93.8 µM 1.18966576135779 0.0965424883000569 no 372 0.11708889383118 623 686268
SGTC_3065 9113888 49.47 µM 1.188920769178 0.0966813934456415 no 373 0.117235423212343 583 16648368
SGTC_1837 st055472 66.5 µM 1.18826751638684 0.0968033143567591 no 374 0.117364015602191 625 676091
SGTC_2692 st077426 47.7 µM 1.18813911650263 0.0968272917515407 no 375 0.117389302778347 647 25238571
SGTC_817 1391-0715 46 µM 1.18492173322241 0.097429530386734 no 376 0.11802419679396 606 1353946
SGTC_415 dibenzyl ketone 100 µM 1.18194560345679 0.0979890526473575 no 377 0.1186136427216 661 7593
SGTC_3271 9137798 49.47 µM 1.18193111716292 0.097991781865194 no 378 0.118616516924188 558 6498326
SGTC_2647 atorvastatin 60.16 µM 1.18134172120112 0.0981028713110642 no 379 0.118733499778284 611 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1829 berberine 14.4 µM 1.18054461650794 0.0982532564675703 no 380 0.118891838116151 619 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_252 miconazole 1.30953 nM 1.17804422780735 0.0987260859078406 no 381 0.119389487300915 620 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_208 k072-0098 12.366 µM 1.17724302281755 0.0988779474100196 no 382 0.119549260619957 728 5948901
SGTC_2240 6690706 185.951 µM 1.17262682556996 0.0997562379733468 no 383 0.120472743540428 550 805876
SGTC_2768 sulfasalazine 50.2 µM 1.1723911247893 0.0998012355065186 no 384 0.120520030565253 641 5384001 An antioxidant and salicylic acid derivative.
SGTC_3020 9089140 49.47 µM 1.172248764936 0.0998284205450364 no 385 0.12054859757283 622 17217859
SGTC_56 0957-0365 83.25 µM 1.16766776495035 0.100706097963694 no 386 0.121470402116288 655 6752360
SGTC_2861 9024595 19.48 µM 1.165574891348 0.101108940891908 no 387 0.12189318222275 534 16482810
SGTC_1998 st075797 76.8 µM 1.16487370671893 0.101244169433197 no 388 0.122035058993966 721 24208315
SGTC_2284 7945075 39.21 µM 1.16232238561253 0.101737322299019 no 389 0.122552268455872 727 1245402
SGTC_966 1300-0360 30.2 µM 1.15907949693769 0.102366671472577 no 390 0.123211891191755 651 70588
SGTC_2004 4023728 41.89 µM 1.15824453547487 0.102529170257444 no 391 0.123382129320516 662 360084 YDR527W RBA50
SGTC_2955 9076254 12.21 µM 1.15817228913719 0.102543239527653 no 392 0.123396867181205 604 16459619
SGTC_1227 3909-8010 46.6 µM 1.15513157964309 0.103136661333248 no 393 0.124018273957432 639 15982272
SGTC_792 4534-1957 155 µM 1.15511169385099 0.103140550415753 no 394 0.124022345060475 661 1717904
SGTC_897 1000-0139 31.4 µM 1.15474196402475 0.103212878214375 no 395 0.124098054739924 656 6151020
SGTC_2109 5483026 200 µM 1.15348307200056 0.103459423108928 no 396 0.12435608088152 673 759335
SGTC_2002 4023503 131 µM 1.15292187994249 0.103569466154846 no 397 0.124471225246908 778 4736863 YCR052W RSC6
SGTC_2463 5473429 200 µM 1.15168191431963 0.103812909689636 no 398 0.124725903396995 641 5399405
SGTC_2492 derrusnin 100 µM 1.14903089623929 0.104334778176183 no 399 0.125271620469029 594 1715307 Part of coumarin class of compounds.
SGTC_860 0443-0016 25.1 µM 1.14337148851754 0.105455221960135 no 400 0.126442192497759 672 5337942
SGTC_877 0771-0151 33.1 µM 1.14319808444986 0.105489689203491 no 401 0.126478178712385 689 6166523
SGTC_1049 3226-0134 66 µM 1.14188027081337 0.105751895134729 no 402 0.126751895215073 712 5702385
SGTC_105 0111-0055 734.78 µM 1.14169749119503 0.105788300045284 no 403 0.126789892005685 582 5179370
SGTC_1415 3966-0071 78.1 µM 1.13841873909909 0.106442880962978 no 404 0.127472836452012 657 2893185
SGTC_2186 6124449 200 µM 1.13738699722944 0.106649464983785 no 405 0.127688270279987 661 3834182 YLR033W RSC58
SGTC_3199 9111318 49.47 µM 1.13680372788802 0.106766380031108 no 406 0.127810172300434 674 8548020
SGTC_2665 lovastatin 100 µM 1.13624852157112 0.106877755801833 no 407 0.127926284323511 659 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2650 prasterone 100 µM 1.13170390158436 0.107792570232757 no 408 0.128879470345161 578 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1824 st053723 68.6 µM 1.13122650940597 0.107888993806178 no 409 0.128979883482013 662 675225
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.13047369800675 0.108041172685097 no 410 0.129138337623838 501 6708630 An antioxidant.
SGTC_408 cantharidin 100 µM 1.12904349374978 0.108330710368947 no 411 0.12943974320334 699 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3295 9122362 53.5725 µM 1.12531594024788 0.109087958011065 no 412 0.130227588672926 645 4730473
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.12177019111925 0.109811795647306 no 413 0.130980081775396 749 1273210
SGTC_1235 benzylparaben 21.5 µM 1.12056233564921 0.110059155558538 no 414 0.131237102395274 662 7180
SGTC_326 k292-0812 17.5 µM 1.12029100872839 0.110114776258107 no 415 0.131294886165681 665 3579357
SGTC_2669 eugenol 100 µM 1.11936686674053 0.110304372169359 no 416 0.131491830038243 627 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2568 diosmetin 100 µM 1.11684894320684 0.1108221340321 no 417 0.132029459040585 723 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2318 6029776 164 µM 1.11420486160475 0.111367709707613 no 418 0.132595655130384 688 818325
SGTC_1393 3470-5649 58.2 µM 1.1120914486461 0.11180516844369 no 419 0.133049416544033 581 4108395
SGTC_492 tmb-8 126 µM 1.11168807238234 0.111888803426994 no 420 0.133136144981804 523 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2113 5491891 107.031 µM 1.11084345354235 0.112064069390049 no 421 0.133317869358324 709 789979
SGTC_502 l-744,832 89.3 µM 1.11077739857844 0.112077784656212 no 422 0.133332088637715 716 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1096 rimcazole 32.2 µM 1.1106628085188 0.112101580312029 no 423 0.133356758268238 660 18528119 A dopamine reuptake inhibitor.
SGTC_2606 farnesol 9.78 µM 1.10942951176373 0.112357914096456 no 424 0.133622468508884 710 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_413 propylparaben 100 µM 1.10891134571708 0.112465736842503 no 425 0.13373421442563 670 7175 A pharmaceutical preservative.
SGTC_2642 cholecalciferol 100 µM 1.10755363504144 0.112748607030315 no 426 0.134027318307428 687 9821465 A vitamin D precursor, similar to steriods.
SGTC_1819 st053448 58.6 µM 1.10574994377676 0.11312517957689 no 427 0.134417383136 698 2857616
SGTC_3013 9080133 71.4286 µM 1.1039056461588 0.113511156975782 no 428 0.134817034692578 762 17050193
SGTC_797 k781-0471 270 µM 1.10374283840957 0.11354527468074 no 429 0.134852353568165 731 23738129
SGTC_2008 4012253 172 µM 1.10153648219248 0.114008355904736 no 430 0.13533161779331 714 603940
SGTC_1886 st057356 49.9 µM 1.09974976500275 0.114384345939465 no 431 0.135720582688176 666 24207747
SGTC_2711 st079103 59.1 µM 1.09863094542409 0.114620235134309 no 432 0.135964537063159 680 54693780
SGTC_1556 plumbagin 1.48 µM 1.09828598120027 0.114693036329034 no 433 0.13603981572223 636 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_879 0831-1030 162 µM 1.09110572162153 0.116215832458274 no 434 0.137613182747062 748 1549252
SGTC_297 0986-0032 24 µM 1.09029175392681 0.116389360702257 no 435 0.137792323223366 686 2847425
SGTC_3116 9124943 49.47 µM 1.08760173552258 0.116964147948985 no 436 0.138385482128143 654 41905195 YPL160W CDC60
SGTC_2208 7283366 200 µM 1.08736691376046 0.117014418577537 no 437 0.138437343651618 734 898663
SGTC_1497 4476-2978 41.3 µM 1.08676133294585 0.117144131931563 no 438 0.138571150226628 776 1528379
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.0855707379869 0.117399450274842 no 439 0.138834475902074 689 75037 A free radical scavenger.
SGTC_296 1222-0039 74.9 µM 1.07870497075879 0.118879475582639 no 440 0.140359634536338 673 5984176
SGTC_812 4251-0442 148 µM 1.0775423748647 0.119131390546169 no 441 0.140619015211943 710 5723007
SGTC_3188 9110789 49.47 µM 1.07548381013399 0.11957837080831 no 442 0.141079088391109 725 849217
SGTC_3250 9135583 49.47 µM 1.07425640428688 0.119845442156775 no 443 0.141353889269447 696 7699353
SGTC_2276 7947513 42.08 µM 1.07281260799375 0.120160135882095 no 444 0.141677601372633 657 2105100
SGTC_2941 9056145 11.23 µM 1.07265115350492 0.120195363100873 no 445 0.141713832112387 639 2119517
SGTC_71 0417-1750 47.813 µM 1.06670967660742 0.121496778249841 no 446 0.143051478071514 774 6811472
SGTC_3314 9135860 59.4275 µM 1.05944851405336 0.12310066486278 no 447 0.144697782636676 776 25252478
SGTC_1642 st009582 77.7 µM 1.0592834940868 0.123137287067094 no 448 0.144735344894975 703 6739311
SGTC_1285 0929-0069 65.5 µM 1.05782615239357 0.123461040444379 no 449 0.145067353742459 739 1206237
SGTC_644 1498-1197 63.3 µM 1.0536039390474 0.124402383863364 no 450 0.146032142508551 778 6741615
SGTC_3124 9127567 49.47 µM 1.05188885346117 0.12478619238158 no 451 0.146425273259248 721 17592030
SGTC_1033 k072-0102 21.3 µM 1.05053071657608 0.125090708030664 no 452 0.146737088105729 774 5965931
SGTC_3101 9120531 49.47 µM 1.04986610866463 0.1252399125508 no 453 0.146889837766262 754 24824904
SGTC_2406 ethylparaben 405.7 µM 1.04841074607088 0.125567075409946 no 454 0.147224702312235 645 8434 A possible steroid mimic.
SGTC_1597 7-benzyloxygramine 47.5 µM 1.0483581613423 0.12557890751407 no 455 0.147236811109459 851 260807
SGTC_1465 k213-0056 144 µM 1.04817351321244 0.125620461402379 no 456 0.147279335714366 733 24048857 YMR208W ERG12
SGTC_1645 Cervolide 78 µM 1.04549870646539 0.126223485931104 no 457 0.147896269059546 724 23173 A fragrance.
SGTC_2428 5615643 7.78 µM 1.04523808518741 0.126282349646509 no 458 0.147956472664705 719 2253075
SGTC_298 1391-0729 10 µM 1.04288864272482 0.12681385647517 no 459 0.148499935140586 742 3237558
SGTC_2110 5483698 200 µM 1.04076080747289 0.127296572135031 no 460 0.148993286951651 742 2848765 YHR062C RPP1
SGTC_1169 aniline yellow 25.8 µM 1.04027841779378 0.127406183409023 no 461 0.14910528407491 733 6051 A DNA damaging agent.
SGTC_1815 st051655 58.2 µM 1.03851976300322 0.127806350565641 no 462 0.14951406963469 745 5984156
SGTC_1104 tacrolimus 29.8 µM 1.03735612596332 0.128071606121539 no 463 0.149784958769661 806 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2649 anisomycin 9.56 µM 1.03637056766331 0.128296566854824 no 464 0.150014647937908 750 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_57 miconazole 162.5 nM 1.03596212450111 0.128389877297205 no 465 0.150109906403314 723 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2967 9089538 49.85 µM 1.03484780574977 0.128644687355999 no 466 0.150369996542847 785 728216
SGTC_94 0334-0113 514.748 µM 1.03209031089519 0.129276748663844 no 467 0.151014906190778 780 6795178
SGTC_636 0kpi-0074 126 µM 1.03096699661392 0.129534846007676 no 468 0.151278148401755 734 616434
SGTC_1636 st007707 68.9 µM 1.02930097291261 0.129918295493005 no 469 0.151669133133388 803 403051
SGTC_3075 9116269 49.47 µM 1.02864677906728 0.130069078406418 no 470 0.151822843724559 762 17015205 YNL244C SUI1
SGTC_237 nikkomycin 200 µM 1.02829839283001 0.130149426170749 no 471 0.151904743420524 793 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3052 9092717 49.47 µM 1.02727364332196 0.130385961591722 no 472 0.152145814758792 737 25237534
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.02597237146104 0.130686752949563 no 473 0.152452303643862 713 521171
SGTC_1826 st055655 41.6 µM 1.02541934213106 0.13081473183268 no 474 0.152582682763369 789 676168
SGTC_2621 lithochol-11-enic acid 100 µM 1.02534398042998 0.130832178310304 no 475 0.152600455344681 818 6708711
SGTC_889 0919-1524 82.7 µM 1.0249031297886 0.130934268878999 no 476 0.152704448850379 725 3905452
SGTC_3203 9113543 49.47 µM 1.02445622735684 0.131037817072461 no 477 0.152809917900141 729 17018012
SGTC_1057 3448-5381 134 µM 1.02392235518694 0.131161590474787 no 478 0.152935975134315 796 5497911
SGTC_946 3434-1334 87.4 µM 1.02348179047193 0.131263792191596 no 479 0.153040052637802 749 4047976
SGTC_366 0181-0206 4.31 µM 1.02195130359576 0.131619260163152 no 480 0.153401974409061 803 274874
SGTC_2685 mycophenolic acid 18.85 µM 1.02097397560126 0.131846599768967 no 481 0.153633384360258 770 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2603 homopterocarpin 100 µM 1.01922638834922 0.132253786955745 no 482 0.154047750792268 772 101795 A weak amylase inhibitor.
SGTC_1989 st071868 50.2 µM 1.01824440595978 0.132482968507137 no 483 0.154280910564998 814 16414057
SGTC_1389 3405-0187 19 µM 1.01193289655991 0.133962521380555 no 484 0.155785069489505 719 799890
SGTC_2910 7948405 25.97 µM 1.01105666697386 0.134168822466219 no 485 0.155994654358912 747 2971328
SGTC_138 0850-0259 40.9225 µM 1.01013714108518 0.134385551875779 no 486 0.156214794998982 873 6813004
SGTC_1243 0416-0003 5.65 µM 1.00871483212246 0.134721258964781 no 487 0.156555708205074 742 2141977
SGTC_1233 0325-0408 14.2 µM 1.00243261953299 0.136210928856725 no 488 0.158067347167426 798 12874
SGTC_454 lyso-paf C-16 6.67 µM 1.00070300592472 0.136623035008353 no 489 0.15848520687157 814 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1888 azatryptophan 97.5 µM 1.0003162354058 0.136715305354459 no 490 0.158578746320318 725 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.998262748361081 0.1372059113286 no 491 0.159075983108071 833 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1961 st076550 68.7 µM 0.995416698826272 0.137887857455189 no 492 0.159766820125365 734 1579337
SGTC_127 0180-0333 59.125 µM 0.992509236775813 0.138586902621075 no 493 0.160474587946662 869 771601
SGTC_425 3825-7017 13.1 µM 0.98761866314595 0.139768188436231 no 494 0.161669721259368 843 3397440
SGTC_2537 larixol 68.93 µM 0.986816078280653 0.139962699428837 no 495 0.161866405577645 867 6708759
SGTC_3178 9107506 49.47 µM 0.986631301674249 0.140007507125385 no 496 0.161911709662827 804 8897194
SGTC_1139 k015-0024 46.9 µM 0.986037247527595 0.140151629267484 no 497 0.162057417614441 819 2766652
SGTC_1947 st076332 61.6 µM 0.985232173548943 0.14034710724752 no 498 0.162255020175659 773 24208416
SGTC_1760 st045453 10.4495 µM 0.984276724035451 0.140579337676353 no 499 0.162489735343654 861 3323419 YIL048W NEO1
SGTC_1657 st012939 43.4 µM 0.983757626513361 0.140705618197488 no 500 0.162617349120637 783 24207257
SGTC_1703 st026983 48.3 µM 0.981292440565255 0.14130637305624 no 501 0.16322427474655 864 1104023
SGTC_1123 mangostin 811.285 nM 0.981148082727043 0.141341606227886 no 502 0.163259861022998 789 5281650 An antioxidant.
SGTC_2594 a-mangostin 100 µM 0.979861066829308 0.141655989194777 no 503 0.16357735168714 819 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_702 1488-0190 94 µM 0.979586905681896 0.141723020458133 no 504 0.163645035563251 824 949357
SGTC_2723 salbutamol 83.58 µM 0.978789145305392 0.141918191757272 no 505 0.163842087068662 749 9884233 β2-adrenoceptor agonist
SGTC_1591 genipin 88.4 µM 0.97574174086369 0.14266541106164 no 506 0.164596230879858 807 442424 A DNA cross-linking agent.
SGTC_1274 0865-0114 173 µM 0.974791842279493 0.142898867688317 no 507 0.164831762231598 816 870624
SGTC_2206 7254556 146.969 µM 0.974554163723432 0.14295732232029 no 508 0.164890729757934 811 4398905
SGTC_1236 0330-0013 258 µM 0.97429964186244 0.143019937306693 no 509 0.164953891217764 804 4617066
SGTC_251 melphalan 456.522 µM 0.972129909588854 0.143554465948777 no 510 0.165492962073092 923 460612 A DNA alkylator.
SGTC_260 nsc-65238 3.989 µM 0.97059052935707 0.143934519715581 no 511 0.165876111970916 821 3246252
SGTC_2133 5320837 200 µM 0.970497642855062 0.143957473924879 no 512 0.165899249637892 763 2841355
SGTC_36 0335-0881 14.2 µM 0.970328181248455 0.143999357814915 no 513 0.165941467240111 869 23828853
SGTC_210 3551-0445 56.827 µM 0.968669543979261 0.144409738120316 no 514 0.166355046451628 834 2865180 YOR207C RET1
SGTC_1702 st027038 51 µM 0.96672781404196 0.144891161762552 no 515 0.166840059437271 838 5521182
SGTC_1746 st038117 42 µM 0.965166156237479 0.145279135219034 no 516 0.167230797688691 812 2898218
SGTC_1407 3909-7909 12.3 µM 0.964031366941046 0.145561496871028 no 517 0.167515100056848 876 4411780
SGTC_3040 9091894 49.47 µM 0.962433607389196 0.145959681352075 no 518 0.167915919353431 769 25236966
SGTC_1946 st076057 65.1 µM 0.962246779016386 0.146006289397651 no 519 0.167962828024657 714 953009
SGTC_1425 4048-4433 7.33 µM 0.96143885692922 0.146207956706224 no 520 0.168165777343828 897 23734946
SGTC_3086 9117350 49.47 µM 0.961028088804181 0.146310561195223 no 521 0.168269022410906 802 2679265
SGTC_3304 9125678 46.087 µM 0.96017204116433 0.146524546009499 no 522 0.168484317856556 818 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3062 9077494 49.47 µM 0.95887779837955 0.146848464431066 no 523 0.168810155263866 808 16459633
SGTC_1539 benzyladenosine 56 µM 0.958827238063087 0.146861128226436 no 524 0.168822892496399 823 92208 A nucleotide analog.
SGTC_954 1189-0853 2.85 µM 0.956868918902945 0.147352190299715 no 525 0.169316710381622 882 2828194
SGTC_1476 4112-3294 3.34 µM 0.955768938751798 0.147628500011195 no 526 0.169594492186197 864 704369
SGTC_216 k038-0035 28.382 µM 0.955374709296771 0.147727612974026 no 527 0.169694119446379 798 4444231 YPR107C YTH1
SGTC_353 1988-1175 58.3 µM 0.953655280408309 0.148160414357228 no 528 0.170129081803166 801 2788357
SGTC_2935 9038016 29.96 µM 0.953183333848999 0.148279357357468 no 529 0.170248594550235 891 6463195
SGTC_1022 4477-0945 21.3 µM 0.953098816627326 0.148300664672196 no 530 0.170270002831721 836 4648966
SGTC_2744 captopril 92.04 µM 0.950827107981739 0.148874143891741 no 531 0.170846074594143 801 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2 0422-0095 29 µM 0.950328630829213 0.149000179450986 no 532 0.170972647703246 736 6790840
SGTC_1727 st034309 9.9045 µM 0.949708950524001 0.149156959519593 no 533 0.171130080286251 925 870305
SGTC_1217 1183-1422 255 µM 0.948431326613275 0.149480547952917 no 534 0.171454958929807 909 2849664
SGTC_1334 1486-0610 236 µM 0.946987359006781 0.149846830479158 no 535 0.17182261019677 853 3742339
SGTC_1378 2093-0007 380 nM 0.944759619882738 0.1504131008548 no 536 0.172390805736999 829 3618014
SGTC_312 4092-0653 6.84 µM 0.944181089158221 0.150560390834755 no 537 0.172538558594453 932 1148278
SGTC_2754 granisetron 64.02 µM 0.944071627322947 0.15058826987624 no 538 0.172566523493793 845 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2789 5281112 71.43 µM 0.943834797531255 0.150648600269127 no 539 0.172627037771813 826 765948
SGTC_439 amiodarone 34.4 µM 0.943520143769335 0.150728780558214 no 540 0.17270745840282 857 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1138 3761-0006 1.03 µM 0.94325590596181 0.150796135765311 no 541 0.172775011942742 866 12061087
SGTC_2262 9014885 67.46 µM 0.942511792527654 0.150985920722616 no 542 0.172965338244367 813 6457424
SGTC_3175 9106517 49.47 µM 0.941931897025358 0.151133932319704 no 543 0.173113754131579 839 41468073
SGTC_706 4262-0057 46.9 µM 0.935277586150323 0.152839276208982 no 544 0.174822631616273 858 883298
SGTC_1145 3546-0597 10.2 µM 0.934520829217483 0.153034020244633 no 545 0.17501764833827 882 875334
SGTC_3183 9108214 49.47 µM 0.926274239473225 0.155166859412997 no 546 0.177151739884112 803 4974831
SGTC_3287 9117173 37.0625 µM 0.923931805748448 0.155776251392929 no 547 0.177760911089603 858 2789709
SGTC_3015 9080845 49.47 µM 0.921215301081142 0.15648493276818 no 548 0.178469015619872 955 5296973
SGTC_2837 9008476 45.46 µM 0.920082498962864 0.15678108427821 no 549 0.178764824583546 886 2992805
SGTC_1900 st060200 72.8 µM 0.919049445867032 0.157051479478609 no 550 0.179034854981739 886 688945
SGTC_1723 st034307 2.5525 µM 0.918900594632633 0.157090465627645 no 551 0.179073784442229 897 867466
SGTC_2724 maprotiline 69.64 µM 0.917819332808059 0.157373853738009 no 552 0.179356729558074 907 4011 A tricyclic antidepressant.
SGTC_3096 9117468 49.47 µM 0.916341919057693 0.157761612321024 no 553 0.179743794074133 784 41316311
SGTC_244 nsc-207895 1.295 µM 0.915945974709093 0.157865637491225 no 554 0.179847615801419 783 42640
SGTC_3001 9076041 71.4286 µM 0.915601945001773 0.157956059860794 no 555 0.179937855414977 875 16004211
SGTC_2383 9036125 200 µM 0.912933320705404 0.158658617198605 no 556 0.180638805822822 871 79580
SGTC_2044 5102272 200 µM 0.911998016876207 0.158905334794422 no 557 0.180884880754495 816 592666
SGTC_1495 4469-0029 237 µM 0.90923051328226 0.159636828073893 no 558 0.181614230374567 971 793680
SGTC_1872 amphotericin b 148 nM 0.90793616970047 0.159979697881017 no 559 0.181955973229937 945 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_385 1494-0393 12.4 µM 0.907057248590846 0.160212797200812 no 560 0.182188262039456 918 3090647
SGTC_577 r071-0003 38.6 µM 0.905923679564451 0.160513759533982 no 561 0.182488124930789 1032 4568517 YMR134W ERG29
SGTC_621 3584-0052 32.1 µM 0.902847733429808 0.16133228220629 no 562 0.183303356707108 939 2273927
SGTC_790 1575-0012 79.1 µM 0.902062219446482 0.161541746520441 no 563 0.183511908460705 947 378741 YLR208W SEC13
SGTC_2994 9053520 71.4286 µM 0.900977151935397 0.161831380942627 no 564 0.183800233966972 914 4647384
SGTC_2185 6113692 200 µM 0.89859200997684 0.162469229668433 no 565 0.184435008073951 836 874150
SGTC_1508 1080-0625 72.9 µM 0.897133647855914 0.162860038357623 no 566 0.184823802940755 867 767111
SGTC_2778 tioconazole 65.09 nM 0.893624925028792 0.163802800619225 no 567 0.18576130290069 867 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2718 lomofungin 53.02 µM 0.892507987356787 0.164103653498357 no 568 0.186060356735507 888 5351222 A RNA synthesis inhibitor.
SGTC_3297 9117502 71.43 µM 0.89210416187581 0.164212514122579 no 569 0.18616855217394 934 7453720
SGTC_280 3448-3607 3.04 µM 0.883852293351355 0.166447250823262 no 570 0.188387976529343 953 626179
SGTC_2780 5215298 71.43 µM 0.882500263361723 0.166815265355656 no 571 0.188753168703201 974 2834131
SGTC_1505 k297-0037 20.6 µM 0.878155305859756 0.168001488070111 no 572 0.189929721451808 921 4089396
SGTC_1811 st050069 61.5 µM 0.876744239942995 0.168387890064405 no 573 0.190312785829426 942 3877702
SGTC_2841 9004761 38.96 µM 0.876361706465517 0.168492740261564 no 574 0.190416714528711 890 2991039
SGTC_294 k038-0071 157 µM 0.876062662948267 0.168574735575068 no 575 0.190497984506792 943 24152826
SGTC_209 4077-0173 175.592 µM 0.875901250100444 0.168619004330023 no 576 0.190541859943162 841 15993494
SGTC_3283 9109332 35.8195 µM 0.873224784885911 0.169354135224106 no 577 0.191270284028907 851 17027281
SGTC_2860 9025725 38.96 µM 0.872943931837874 0.169431394760156 no 578 0.191346819544516 882 40546248
SGTC_1805 st050013 60.3 µM 0.871386107754749 0.169860345359683 no 579 0.191771684276163 917 4037144
SGTC_3257 9139206 32.98 µM 0.869331354466056 0.170427190536533 no 580 0.192332958910096 926 4910041
SGTC_1406 3909-7906 11.9 µM 0.867278463611665 0.17099473031826 no 581 0.192894726918203 955 X1406
SGTC_3047 9092122 49.47 µM 0.867147822919654 0.171030887961379 no 582 0.192930510275109 913 17173831
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.867003625397775 0.171070803428831 no 583 0.192970011644928 1034 65057 A dermal irritant. YDR527W RBA50
SGTC_2080 5212524 12.4 µM 0.85982892567047 0.173064360518668 no 584 0.194941675927122 945 260183
SGTC_1861 st057647 17.4 µM 0.858898116500327 0.173324074742788 no 585 0.195198364330208 965 688668
SGTC_629 3448-6466 76.7 µM 0.858542066891738 0.17342348522569 no 586 0.195296606096007 977 573744
SGTC_2126 5251174 33.877 µM 0.857731235095987 0.173650008130779 no 587 0.195520444153501 1037 790722
SGTC_180 1486-1293 102.781 µM 0.857693405893451 0.173660581107941 no 588 0.195530891077831 965 4140536
SGTC_2416 tofa 880 nM 0.856821566850024 0.173904367039742 no 589 0.195771752337831 856 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_742 0kpi-0133 140 µM 0.856169349744672 0.174086883934567 no 590 0.19595205677092 985 2728852
SGTC_75 0159-0059 199.013 µM 0.85567039519382 0.174226593905663 no 591 0.196090059996841 949 5377270
SGTC_231 b-estradiol 524 µM 0.848084985621295 0.176359319491899 no 592 0.198195321351686 907 450 A steroid.
SGTC_2221 6807166 181.081 µM 0.847067424833288 0.176646669825189 no 593 0.19847877040499 935 674925
SGTC_669 0108-0021 26.2 µM 0.844510085482229 0.177370146335354 no 594 0.199192214985427 1071 17201
SGTC_734 2023-0417 80 µM 0.842370757839588 0.177976801462246 no 595 0.199790227937249 959 3935732
SGTC_2645 abamectin 100 µM 0.841532952146084 0.178214736477105 no 596 0.200024716355955 957 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2374 9071832 200 µM 0.8412979766211 0.178281505003562 no 597 0.200090511947217 958 17381698
SGTC_1562 morin hydrate 59.1 µM 0.840502560429979 0.17850764027588 no 598 0.200313333294425 955 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_665 3914-0008 307 µM 0.839752947107886 0.178720919169778 no 599 0.200523460196041 973 1069549
SGTC_1680 diphenhydramine 100 µM 0.838872448699804 0.178971642107595 no 600 0.200770444966035 950 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1021 4476-0760 85.3 µM 0.838565068348533 0.179059221112923 no 601 0.200856709866296 970 746768
SGTC_317 4495-0002 170 µM 0.837748914785104 0.179291890920631 no 602 0.201085867566797 932 15991618
SGTC_1171 0368-0077 21.4 µM 0.83665019560348 0.179605414894445 no 603 0.201394610902879 938 3239779
SGTC_1672 st016598 6.51 µM 0.834995096123458 0.180078354224791 no 604 0.201860234734334 936 4665860 YNL267W PIK1
SGTC_2675 theaflavin digallate 100 µM 0.834337545006461 0.180266464146461 no 605 0.202045400236877 1001 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_373 0844-0104 25.9 µM 0.834114901731995 0.180330185091049 no 606 0.202108119309808 1045 5375804
SGTC_386 1509-0011 3.07 µM 0.832709106402723 0.18073285277996 no 607 0.202504403715493 1053 3107280
SGTC_2678 equilin 100 µM 0.832594476089634 0.180765711646554 no 608 0.20253673771346 1035 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2123 5259487 200 µM 0.831890064388835 0.180967714008406 no 609 0.20273550025423 1014 2173474
SGTC_2616 abietic acid 100 µM 0.831097645428881 0.181195122986039 no 610 0.202959234889392 1035 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_635 k038-0028 24.7 µM 0.83084587507839 0.181267413679636 no 611 0.203030351561484 987 4035102
SGTC_293 4049-0273 38.5 µM 0.830329796177793 0.181415651601332 no 612 0.203176173029105 947 1380311
SGTC_1574 spiramycin 23.7 µM 0.829374693839044 0.18169019425324 no 613 0.203446208298113 1037 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_904 1141-0088 396 µM 0.829118169744403 0.18176397596088 no 614 0.203518771594896 976 1378119
SGTC_173 1273-0061 2.693 µM 0.828517308385048 0.181936869642606 no 615 0.20368879842767 963 2847414 YPL266W DIM1
SGTC_930 2810-3379 265 µM 0.827922510535172 0.182108119849323 no 616 0.203857192845447 1054 1015764
SGTC_796 1234-0020 70.7 µM 0.827800976683717 0.182143123454835 no 617 0.203891610745179 1017 46495034
SGTC_2093 5331342 194.4 µM 0.826354963070431 0.182559920116046 no 618 0.20430138166535 1013 33839
SGTC_1603 st002045 67.8 µM 0.82571547978814 0.182744433567025 no 619 0.204482754513438 1019 5887985
SGTC_378 3970-0959 8.33 µM 0.825043793038882 0.182938364170994 no 620 0.204673364192806 997 6615653
SGTC_2176 5809774 33.9695 µM 0.820010490731847 0.184395672321371 no 621 0.206105063358671 1037 2870539
SGTC_2982 9019404 25.97 µM 0.819886561759256 0.184431644736477 no 622 0.206140389112691 945 22333232
SGTC_2146 5545642 200 µM 0.816960826412648 0.185282155047637 no 623 0.206975407550763 1055 825326
SGTC_968 1309-0633 340 µM 0.816903541147621 0.185298832128086 no 624 0.206991776984611 1013 3761976
SGTC_1649 st011737 51.3 µM 0.816668504057806 0.185367266678749 no 625 0.207058947547101 987 1761035
SGTC_594 1487-1584 10.8 µM 0.812963178411892 0.186448200101681 no 626 0.208119584891246 1051 5013332
SGTC_2166 5933061 31.504 µM 0.81218050740425 0.186677022686723 no 627 0.208344031396947 1159 2877375
SGTC_586 0957-0265 8.15 µM 0.811356681880032 0.18691806497576 no 628 0.208580433952689 942 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1461 k072-0203 53.8 µM 0.811312025501012 0.186931136441476 no 629 0.208593252933063 976 5418714
SGTC_1151 3909-8316 15.3 µM 0.810833213447898 0.187071326100126 no 630 0.208730729050885 1010 800431
SGTC_828 2074-0507 139 µM 0.808515732946061 0.187750771600525 no 631 0.209396876404274 1056 X828
SGTC_256 clotrimazole 625 nM 0.80771943230851 0.187984584687955 no 632 0.209626057211645 1002 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2747 doxorubicin 7.63 µM 0.807300579149468 0.188107642197232 no 633 0.209746665217101 880 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_905 2-aminofluorene 215 µM 0.806376505508522 0.188379307404419 no 634 0.21001289479308 1107 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.805965897603617 0.188500098218439 no 635 0.210131256377952 1003 756377
SGTC_1675 st018485 24.5 µM 0.805224697622819 0.188718262036525 no 636 0.21034501341636 1026 3323024
SGTC_729 4092-0585 94.1 µM 0.805022716079323 0.188777739989245 no 637 0.210403285649179 1009 2169061
SGTC_2959 9079155 11 µM 0.804569125302196 0.188911351968317 no 638 0.210534182373248 1001 16189457
SGTC_2742 clothiapine 36.27 µM 0.80392424071341 0.189101412689457 no 639 0.210720364703881 992 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2053 5265679 138 µM 0.802989844313237 0.189377007330783 no 640 0.210990302245211 1055 764595
SGTC_2745 rifampicin 24.3 µM 0.80164048134083 0.189775429901877 no 641 0.2113804769178 931 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2803 7707263 71.43 µM 0.801493728658938 0.189818792207485 no 642 0.21142293661345 995 2199229
SGTC_2452 5863136 48.41 µM 0.800459555822209 0.190124541068813 no 643 0.21172229361753 1051 2184096
SGTC_2200 6600604 21.907 µM 0.798956555382307 0.190569436006981 no 644 0.212157801818905 1034 2904777
SGTC_2980 9014342 25.29 µM 0.798250828378886 0.190778554716819 no 645 0.212362473269396 958 2996599
SGTC_1273 0849-0096 14.1 µM 0.796894411845018 0.191180878831677 no 646 0.212756178308187 1012 5286025
SGTC_1708 st033234 31.827 µM 0.796756284962335 0.191221877544368 no 647 0.212796294051198 1094 674664
SGTC_2472 5377652 49.4 µM 0.796079811146163 0.191422745798321 no 648 0.212992823905135 1023 1610903
SGTC_2999 9069765 71.4286 µM 0.795785461048634 0.191510188782447 no 649 0.213078371847797 1073 2097066
SGTC_800 3448-7362 155 µM 0.794555367377443 0.1918758791398 no 650 0.213436094886005 1182 15991913
SGTC_1316 1272-0050 65.9 µM 0.793861159959142 0.192082446263934 no 651 0.213638131485343 1046 7340392
SGTC_3247 9135149 49.47 µM 0.792982539750785 0.192344081940877 no 652 0.213893997792622 986 8934436 YOR116C RPO31
SGTC_2756 carbadox 75.1 µM 0.792436567651906 0.192506771341358 no 653 0.214053082230548 1005 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1417 3966-0327 90.4 µM 0.789850149010927 0.193278617934567 no 654 0.214807643808781 1091 651118
SGTC_2034 5197015 53.07 µM 0.789637413590177 0.193342187009172 no 655 0.214869775928659 1031 780676
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.78854181586358 0.193669772821763 no 656 0.215189924636626 1044 364106
SGTC_907 3448-6986 75.5 µM 0.785520469777133 0.194574913145267 no 657 0.216074236730063 1093 590582
SGTC_1881 5652484 16 µM 0.783440995504337 0.195199378878617 no 658 0.216684095115287 1024 2255129
SGTC_1173 0443-0020 122 µM 0.782280689995129 0.195548347187225 no 659 0.217024816304177 1047 5331295
SGTC_523 1934-0222 13.7 µM 0.782189420768652 0.19557581297498 no 660 0.217051630442482 1051 1361595
SGTC_2127 5253358 187.912 µM 0.781025956148287 0.195926141378722 no 661 0.217393614366398 1001 20612
SGTC_1191 1487-1166 10.6 µM 0.780250276242732 0.196159916135888 no 662 0.217621787218509 1137 3955771
SGTC_3082 9117008 49.47 µM 0.779616387532361 0.19635108333971 no 663 0.217808353554067 1047 41448529
SGTC_2971 9092186 9.93 µM 0.777573674794567 0.196967889473639 no 664 0.218410192732377 1001 25236400
SGTC_2740 felodipine 17.08 µM 0.777044437792152 0.197127886026103 no 665 0.218566276545861 1023 3333 L-type calcium channel blocker
SGTC_2831 7999036 19.48 µM 0.776444151581461 0.197309457014031 no 666 0.218743392065049 1076 2988270
SGTC_2143 5623677 140.463 µM 0.775638604141225 0.197553273090868 no 667 0.21898120002149 1071 5375313
SGTC_2009 4012297 12.05 µM 0.77532936052629 0.197646920613933 no 668 0.219072532195644 1025 45595307
SGTC_1915 st067105 30.6 µM 0.772179424747124 0.198602336101878 no 669 0.220004082986908 1094 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1808 st050063 61.5 µM 0.77201434533632 0.198652483478124 no 670 0.220052965576993 1070 4011993
SGTC_490 phenamil 164 µM 0.769303535441767 0.199477057782369 no 671 0.220856569459693 1004 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2770 toltrazuril 17.5 µM 0.769287884777636 0.199481824376133 no 672 0.220861213881437 1093 68591 Kills coccidiodes.
SGTC_2395 5646831 180.19 µM 0.767480986852256 0.200032597162188 no 673 0.221397796685311 1059 6808628
SGTC_2215 7188065 200 µM 0.766847379818206 0.200225947505557 no 674 0.221586131246111 1088 940217
SGTC_511 blebbistatin 171 µM 0.765805850771877 0.200544022507945 no 675 0.221895916199103 1091 3476986 A myosin inhibitor.
SGTC_44 0929-0055 61.211 µM 0.765246672339082 0.200714916434138 no 676 0.222062336222665 1053 1379590
SGTC_2601 securinine 100 µM 0.765115223207262 0.200755102090226 no 677 0.222101467828412 1075 442872 A GABA receptor antagonist.
SGTC_327 1273-0057 3.96 µM 0.762846901931833 0.201449316895343 no 678 0.22277735297236 1046 3108138
SGTC_2385 9074692 200 µM 0.76281596012555 0.20145879650306 no 679 0.222786580708941 1093 17046906
SGTC_1261 0712-0010 12.7 µM 0.762454384930807 0.201569591716924 no 680 0.222894428974301 1107 2840123
SGTC_3251 9135047 49.47 µM 0.760573361331112 0.202146570663191 no 681 0.223455967897019 1075 17682963
SGTC_2912 7964298 10.93 µM 0.759097429625646 0.202599984185142 no 682 0.223897138320414 1120 2975850
SGTC_714 4296-0578 26.1 µM 0.758996268823745 0.202631083527932 no 683 0.223927394388305 1117 1589775
SGTC_2021 4019055 173 µM 0.758945717814845 0.20264662523253 no 684 0.223942514501938 1128 44827708 YER133W GLC7
SGTC_3329 9141233 27.5565 µM 0.758022832903781 0.202930487701145 no 685 0.224218656933888 1092 4909101 YNL103W MET4
SGTC_3324 9138759 60.749 µM 0.75765741171285 0.203042950158377 no 686 0.224328050412202 1098 45595710
SGTC_2952 9073731 13.78 µM 0.756667437884001 0.203347812596055 no 687 0.224624563834895 1157 16457353
SGTC_935 2996-0153 430 µM 0.756637010459841 0.203357187045654 no 688 0.224633680868467 1104 23738523
SGTC_1310 1188-0297 994 nM 0.755230352955211 0.203790848598831 no 689 0.225055389728554 1079 1588352
SGTC_1594 piperine 70.1 µM 0.754962686737195 0.203873430394034 no 690 0.225135685490155 1080 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_328 k915-0120 63.5 µM 0.754406343513837 0.204045140138675 no 691 0.22530263184203 1083 6624543
SGTC_2373 9071805 200 µM 0.752966520588746 0.204489926850675 no 692 0.225735016336924 1115 10149009
SGTC_1222 0366-0074 1.18 µM 0.75036568119875 0.205294833083675 no 693 0.226517247181609 1158 286520
SGTC_3230 9131665 49.47 µM 0.749568915259534 0.205541791835572 no 694 0.226757189112489 1060 15943720
SGTC_2122 5258151 111.688 µM 0.749421843850466 0.205587396106486 no 695 0.226801494578213 1094 2173356
SGTC_3179 9107801 49.47 µM 0.748555009480928 0.205856308291177 no 696 0.227062728835258 1132 4818259
SGTC_2788 5282734 71.43 µM 0.745484621798003 0.2068104912127 no 697 0.227989402161334 1146 743706
SGTC_3298 9116858 71.43 µM 0.744909319974463 0.206989568292551 no 698 0.228163270269291 1126 2506942
SGTC_2121 5257820 149.641 µM 0.744216202523824 0.207205440253017 no 699 0.228372843676716 1174 791256
SGTC_1435 4092-0789 56.7 µM 0.743761005007086 0.207347284278231 no 700 0.228510537613012 1121 2248285
SGTC_2037 5169046 200 µM 0.743227358236818 0.207513646945068 no 701 0.228672021247586 1109 5718022
SGTC_1358 1509-0022 2.48 µM 0.7429498195818 0.207600199903422 no 702 0.228756030871335 1137 3258434
SGTC_2648 atorvastatin 78.68 µM 0.741649205860461 0.208006092267098 no 703 0.229149951199962 1122 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3133 9127736 49.47 µM 0.741396425740389 0.208085033611064 no 704 0.229226555517711 1130 27243420
SGTC_2894 9048625 32.47 µM 0.741264699703331 0.208126177676207 no 705 0.229266480420283 1157 4092861
SGTC_1416 3966-0321 25.3 µM 0.739378568488802 0.208715829079127 no 706 0.229838576170324 1154 582530 YLR208W SEC13
SGTC_3346 9158254 43.5805 µM 0.736079103454945 0.209749688083293 no 707 0.230841279504489 1096 17639500
SGTC_693 4161-2696 114 µM 0.735238472348183 0.210013573108059 no 708 0.231097136187184 1113 805759
SGTC_785 1270-0111 65.3 µM 0.733824411370369 0.210457905012917 no 709 0.231527880287391 1151 6741994
SGTC_2296 7971656 126.45 µM 0.733682009874135 0.210502681543572 no 710 0.231571282702427 1150 666570
SGTC_2522 biochanin a 4.94 µM 0.733367468962426 0.210601605167815 no 711 0.23166716739455 1107 5280373 A possible chelator.
SGTC_1130 3454-2858 15.9 µM 0.733095971730556 0.210687013415447 no 712 0.231749948433018 1072 715628 YIL048W NEO1
SGTC_748 act1.228 77.9 µM 0.729374299009874 0.211859833053794 no 713 0.232886367341717 1126 4421505 YNR035C ARC35
SGTC_4 0960-0234 25.671 µM 0.729132694110642 0.211936102383737 no 714 0.232960248651129 1131 6821112
SGTC_2617 dihydrotanshinone i 20.83 µM 0.72874386957804 0.212058879416009 no 715 0.233079176158214 1177 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1214 0358-0031 63.7 µM 0.72799045321231 0.212296899993532 no 716 0.233309715173611 1131 4301366
SGTC_1604 st002052 72.4 µM 0.726741361689056 0.212691858938944 no 717 0.233692205223355 1178 6254834 YHR062C RPP1
SGTC_2220 6782180 200 µM 0.726690647808232 0.21270790357204 no 718 0.233707741893531 1090 833803
SGTC_359 0081-0058 15.9 µM 0.724165235010449 0.213507775904037 no 719 0.234482149458269 1170 3494159
SGTC_1402 3909-7673 35.9 µM 0.723006508035677 0.213875364599865 no 720 0.234837942930862 1156 5328014
SGTC_1373 2887-0003 58.5 µM 0.721957958598234 0.214208318508945 no 721 0.235160162806476 1127 776948
SGTC_2708 st078559 56 µM 0.721068914415319 0.214490859593077 no 722 0.235433557787181 1084 17250902
SGTC_863 0466-0191 129 µM 0.720883589818244 0.214549783621838 no 723 0.235490570082643 1172 765160 YPR165W RHO1
SGTC_2430 5571206 200 µM 0.718425502000967 0.215332223312567 no 724 0.23624748361992 1209 1731771
SGTC_2555 cholic acid 100 µM 0.718390557189813 0.215343358600379 no 725 0.236258253748298 1139 6708657 Influences liver metabolism.
SGTC_3195 9113082 49.47 µM 0.717956675064466 0.215481644501427 no 726 0.236392000445034 1129 17018038
SGTC_1177 0983-0204 23.6 µM 0.716262551848789 0.216022084468497 no 727 0.236914622690425 1192 766818
SGTC_486 niguldipine 82 µM 0.71531465739397 0.216324813260862 no 728 0.237207316764207 1154 1236 A calcium channel blocker.
SGTC_3234 9132280 49.47 µM 0.714753150909702 0.216504257196227 no 729 0.237380794287207 1175 17612295
SGTC_2049 5262831 67.185 µM 0.713821941932945 0.216802038913706 no 730 0.23766864495082 1192 763417
SGTC_1990 st072050 59.8 µM 0.71374286738363 0.216827336252405 no 731 0.237693096898581 1192 17233948
SGTC_306 1672-3436 11.6 µM 0.712589791799042 0.217196419250959 no 732 0.238049815202474 1186 6797378
SGTC_1926 methyl fluorone black 53.6 µM 0.71163038700947 0.217503787409425 no 733 0.238346842527935 1040 72721 Reacts with homocysteine.
SGTC_2052 5265182 7.135 µM 0.711041289022301 0.217692643320783 no 734 0.238529325096575 1165 1239884
SGTC_559 1550-0661 158 µM 0.710319763850749 0.217924082239983 no 735 0.238752933274864 1174 5830875
SGTC_2827 7993847 71.43 µM 0.709748018635043 0.218107577939404 no 736 0.238930204492308 1113 2985692
SGTC_1796 st049173 110.4 µM 0.708279626485318 0.218579251026254 no 737 0.239385813237962 1139 94134
SGTC_517 1365-0151 113 µM 0.706354877268102 0.219198402435813 no 738 0.239983737147168 1217 768657
SGTC_713 1488-1073 324 µM 0.704498589575082 0.219796485130836 no 739 0.240561164053292 1163 3312542
SGTC_51 1013-0126 23.419 µM 0.702927719244125 0.220303339340419 no 740 0.24105039781166 1242 1627850
SGTC_2571 chrysanthemic acid 100 µM 0.70290751863885 0.22030986159259 no 741 0.241056692634003 1135 2743 An insecticide.
SGTC_3232 9132874 49.47 µM 0.701242770051319 0.220847746152959 no 742 0.241575761231369 1170 3784940
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.701207928380387 0.220859011613872 no 743 0.241586631344215 1147 689007
SGTC_969 1313-0238 134 µM 0.70068687249611 0.221027525407814 no 744 0.241749225154854 1209 5212874
SGTC_851 0394-0702 453 µM 0.700206247766868 0.221183028651487 no 745 0.241899255195799 1195 762646
SGTC_2290 7904846 200 µM 0.699772041258987 0.221323567356459 no 746 0.242034838915502 1217 2962154
SGTC_3100 9120536 49.47 µM 0.697287697148105 0.222128651118792 no 747 0.242811382919333 1097 16421196
SGTC_2458 5808907 16.39 µM 0.6967023833601 0.222318572612551 no 748 0.242994533472509 1262 2731747
SGTC_776 4476-4378 112 µM 0.695888403129496 0.222582845288421 no 749 0.243249360220404 1158 2892008
SGTC_803 4488-1585 147 µM 0.695233443387528 0.222795619201945 no 750 0.243454508437822 1170 747204
SGTC_1778 st046819 58.9 µM 0.694003669312253 0.223195443491535 no 751 0.243839953902923 1241 671715
SGTC_319 1348-1596 45.5 µM 0.693228222836822 0.223447766577817 no 752 0.244083169644354 1244 5380505
SGTC_1628 st004252 77.7 µM 0.692738087947364 0.223607335589975 no 753 0.244236965986344 1181 692968
SGTC_2362 9071156 126 µM 0.692682128873548 0.223625557826435 no 754 0.244254528354123 1204 653133
SGTC_369 0957-0393 4.5 µM 0.692068953394307 0.223825284575466 no 755 0.244447013824374 1192 6997992
SGTC_1954 st077032 68.9 µM 0.692011556737209 0.223843985305202 no 756 0.244465035724145 1135 698907
SGTC_1560 lithocholic acid 53.1 µM 0.691787286188353 0.223917064675572 no 757 0.24453546099723 1141 9903 A bile acid which acts as a detergent.
SGTC_2229 7354935 190 µM 0.690123771870654 0.224459549898744 no 758 0.245058177541818 1163 318112
SGTC_3185 9108267 49.47 µM 0.688832434509641 0.22488117897009 no 759 0.245464361061852 1182 4910486
SGTC_2159 5658611 73.75 µM 0.688722539466691 0.224917081051729 no 760 0.245498944676628 1227 793844
SGTC_553 k007-0256 45.7 µM 0.68872159986937 0.224917388026804 no 761 0.245499240376155 1231 6287000
SGTC_449 xestospongin c 11.1929 µM 0.688296534405599 0.225056285171895 no 762 0.245633031831537 1180 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_112 phenothiazine 287.218 µM 0.688069783623368 0.225130399601838 no 763 0.245704418774019 1204 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1077 5-fluorocytosine 377 nM 0.686973658986809 0.225488867388459 no 764 0.246049663861149 1193 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1198 1612-1005 86.7 µM 0.68528113129626 0.226043012103841 no 765 0.246583268062323 1267 6998509
SGTC_2118 5526350 200 µM 0.684319930228522 0.226358058068294 no 766 0.246886582245839 1206 743594
SGTC_1055 3448-0672 86 µM 0.683484427081033 0.226632106288856 no 767 0.247150393650494 1188 748378
SGTC_507 nimesulide 162 µM 0.681170154261481 0.227392173536689 no 768 0.247881915348295 1244 4495 A COX2 inhibitor.
SGTC_1234 0326-0494 15.5 µM 0.680374033493515 0.227653971843989 no 769 0.248133829162933 1243 1547813
SGTC_383 2324-0395 7.37 µM 0.679209998659653 0.22803706117092 no 770 0.248502406440355 1222 3146421
SGTC_982 1491-0518 27.5 µM 0.679181775779204 0.228046353953118 no 771 0.248511346488304 1191 3091256
SGTC_2874 9043904 71.43 µM 0.678229050478131 0.228360177141281 no 772 0.248813237946577 1168 4463428
SGTC_2769 toremifene 3.73 µM 0.677867198368723 0.228479433070799 no 773 0.248927949692574 1241 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2245 6637752 200 µM 0.677624268934275 0.228559515171548 no 774 0.249004977218202 1191 681890
SGTC_2303 7774051 200 µM 0.676557342567156 0.228911415874825 no 775 0.249343425976161 1223 2953184
SGTC_2444 5485484 36.41 µM 0.675433383863126 0.229282456003183 no 776 0.249700230779275 1271 6790631
SGTC_1163 k060-0048 49.9 µM 0.674934981928056 0.229447095804857 no 777 0.249858537032865 1243 6809982
SGTC_950 1165-0508 94.1 µM 0.674911884979867 0.229454727150441 no 778 0.249865874554561 1203 6148369
SGTC_48 0382-0018 55 µM 0.674493154773264 0.229593102338103 no 779 0.249998918106374 1330 762596
SGTC_657 3534-0529 86.7 µM 0.673728435614427 0.229845934970302 no 780 0.25024199004061 1257 1049549
SGTC_1301 naphtanilide LB 4.81 µM 0.672913903964254 0.230115408041419 no 781 0.250501033032178 1269 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1588 farnesol 29.9 µM 0.672265630473141 0.230330003867186 no 782 0.250707302956067 1251 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_864 0469-0573 172 µM 0.672037558129224 0.230405528501108 no 783 0.25077989319474 1193 689425
SGTC_401 neomycin 50 µM 0.670598511471132 0.230882378329562 no 784 0.251238165517137 1200 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2927 9011802 47.9 µM 0.66820112266048 0.231678011659929 no 785 0.252002609466198 1225 43912568
SGTC_1376 2910-0861 41.3 µM 0.667426222102923 0.231935508117305 no 786 0.252249960523137 1253 1112859
SGTC_3028 9087778 49.47 µM 0.665788533431954 0.232480229707948 no 787 0.252773137547992 1202 17217395
SGTC_1763 st044482 94.5 µM 0.665382042181512 0.232615545361119 no 788 0.252903083937879 1239 88505
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.665286674347531 0.232647298413305 no 789 0.252933576046428 1120 88881 An O-methylated flavonoid and antioxidant.
SGTC_2357 9067248 200 µM 0.66249583182759 0.233577585330011 no 790 0.253826752622631 1242 9150235
SGTC_2468 5987765 72.9 µM 0.662326212355827 0.233634191942722 no 791 0.253881090677714 1277 26772094
SGTC_2317 5986382 200 µM 0.661851548334513 0.2337926406031 no 792 0.254033183019631 1301 877883
SGTC_1463 k081-0032 34.1 µM 0.661788227910534 0.233813782237123 no 793 0.25405347582921 1111 977755
SGTC_2316 5844804 197.44 µM 0.660085077048596 0.234382833262713 no 794 0.254599617292336 1297 776813
SGTC_1284 0929-0043 16 µM 0.659684031500228 0.234516940644107 no 795 0.254728308096243 1238 1239883
SGTC_3167 9103034 49.47 µM 0.659076313162861 0.234720239118079 no 796 0.254923382660442 1254 5127859
SGTC_2949 9072542 2.23 µM 0.65885265211232 0.234795084404532 no 797 0.254995196421046 1266 16457352
SGTC_2327 6189656 200 µM 0.658184851041819 0.235018633903367 no 798 0.25520967895617 1302 5349088
SGTC_830 4076-0286 57.8 µM 0.656169688661583 0.235693931099523 no 799 0.255857474705828 1300 6866659
SGTC_1323 1348-1351 11.2 µM 0.655963646558418 0.235763037723181 no 800 0.255923757494237 1227 6989654
SGTC_2488 5268135 45.7 µM 0.65543977224329 0.235938795734985 no 801 0.256092325774757 1269 1270356 YLR208W SEC13
SGTC_3106 9121286 49.47 µM 0.655300270530789 0.235985610246907 no 802 0.256137223332995 1278 15943471
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.653582448727462 0.236562502796634 no 803 0.256690427439941 1224 688662
SGTC_287 k060-0039 29.6 µM 0.652785733120182 0.236830325337926 no 804 0.256947211246027 1295 5861974
SGTC_2858 9025781 8.96 µM 0.652640821873038 0.236879056366354 no 805 0.256993930932202 1283 4894980 YPL153C RAD53
SGTC_3080 9117754 49.47 µM 0.652014564820255 0.237089718652554 no 806 0.257195888307532 1346 9550191
SGTC_1963 st076565 50.3 µM 0.651943315720465 0.237113692165846 no 807 0.257218870171505 1273 4914280
SGTC_1226 3909-7979 35.4 µM 0.650829826683604 0.237488525967898 no 808 0.257578172022391 1276 6615510
SGTC_2717 st081029 62.2815 µM 0.649121001809448 0.23806439971546 no 809 0.2581300840052 1245 5292846
SGTC_1052 3253-3998 198 µM 0.648880218152017 0.238145605248735 no 810 0.258207900966021 1256 5450317
SGTC_310 1273-0058 1.06 µM 0.647556692460361 0.238592242033853 no 811 0.258635857774175 1281 2734232
SGTC_1892 st058411 7.36 µM 0.64510722542569 0.23942004684523 no 812 0.259428850908433 1249 3934738
SGTC_1732 st034308 51.822 µM 0.645074222147737 0.239431211102014 no 813 0.259439543994111 1236 830119
SGTC_219 mitoxanthrone 164.414 µM 0.642889526944158 0.240170875638072 no 814 0.260147892792801 1274 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2311 7694451 200 µM 0.642526812163626 0.240293799135993 no 815 0.260265593069463 1264 2163142
SGTC_2997 9067075 71.4286 µM 0.641146301283326 0.240761965575177 no 816 0.260713817133392 1283 27209819
SGTC_2546 rhodinyl acetate 100 µM 0.641125543527334 0.240769008845287 no 817 0.260720559788571 1272 6708682
SGTC_381 3461-2219 42.7 µM 0.640952153158563 0.240827845942748 no 818 0.260776884962987 1266 2883159
SGTC_1431 4049-0260 9.09 µM 0.640187159989849 0.241087526842681 no 819 0.261025464686725 1272 3854841
SGTC_1364 1653-0028 37.6 µM 0.639584267366628 0.241292289093053 no 820 0.26122145665976 1270 5718652
SGTC_2761 levamisole 97.89 µM 0.639157481977994 0.241437296617477 no 821 0.261360244326637 1327 26879 An alkaline phosphatase inhibitor.
SGTC_3165 9101544 49.47 µM 0.634760250801654 0.242934082652369 no 822 0.262792395676237 1296 5002184
SGTC_2003 4023581 200 µM 0.634664559116309 0.242966711136514 no 823 0.262823606437894 1318 16641307
SGTC_1448 4255-0083 152 µM 0.634621729283797 0.242981315811866 no 824 0.262837576412948 1355 5399660
SGTC_1008 4106-0037 6 µM 0.634329055398712 0.243081128282341 no 825 0.26293304916824 1274 2905394
SGTC_1411 3909-8223 150 µM 0.630235243239502 0.244479588958933 no 826 0.264270341997395 1295 X1411
SGTC_290 2043-6722 48.1 µM 0.62923704416802 0.244821233395546 no 827 0.264596940097473 1298 773758 YLR208W SEC13
SGTC_3111 9122088 49.47 µM 0.628348213016389 0.245125661630144 no 828 0.264887927113818 1220 16876704
SGTC_2239 6685329 187.64 µM 0.627982055462437 0.245251131244523 no 829 0.265007847666379 1320 805680
SGTC_3208 9114115 49.47 µM 0.626820493950231 0.245649386865235 no 830 0.265388454063627 1264 650895
SGTC_72 0744-0168 198.391 µM 0.62482370047077 0.246334822925937 no 831 0.266043386860205 1281 677577
SGTC_485 niflumic acid 177 µM 0.623443763153415 0.24680911016115 no 832 0.266496473477644 1336 4488 A COX2 inhibitor.
SGTC_1076 itraconazole 331 nM 0.623289757550717 0.246862072504014 no 833 0.266547063652779 1311 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3201 9113999 49.47 µM 0.622730273012341 0.247054529750718 no 834 0.266730892769368 1348 16649224
SGTC_1251 0490-5699 265 µM 0.622303394929246 0.247201425633598 no 835 0.266871194638671 1342 3883818
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.622234442374239 0.247225157741016 no 836 0.266893860747883 1298 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2792 7535235 81.82 µM 0.620974357538127 0.247659068534191 no 837 0.267308247507251 1275 1281891
SGTC_2746 daunorubicin 9.88 µM 0.620778889217278 0.24772641456312 no 838 0.267372557556097 1229 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_995 3931-2021 34.6 µM 0.620568829218117 0.24779879886213 no 839 0.267441677039193 1321 730143
SGTC_1807 st050092 58.9 µM 0.614642347241629 0.249845642574052 no 840 0.26939547081511 1292 5008496
SGTC_3069 9117009 49.47 µM 0.613752436753548 0.250153766353218 no 841 0.269689465918057 1220 41904981
SGTC_84 0443-0269 128.823 µM 0.611458766403131 0.25094885807561 no 842 0.270447954014335 1278 6150058
SGTC_1296 1068-0102 11.9 µM 0.609309168878199 0.251695219814831 no 843 0.27115976539243 1312 767053
SGTC_2815 7968870 71.43 µM 0.607201203866519 0.252428263230288 no 844 0.271858696707654 1320 2977326 YHR190W ERG9
SGTC_104 0074-0074 590.992 µM 0.6050085501834 0.253191949292388 no 845 0.272586657795349 1198 3943124
SGTC_109 0132-0036 33.701 µM 0.603351383767774 0.253769934002753 no 846 0.273137478371034 1233 67274 A color developer.
SGTC_478 N-arachidonylglycine 10 µM 0.601835283034094 0.254299324141268 no 847 0.273641893225829 1284 5283389
SGTC_1903 st060211 78.3 µM 0.600198791465037 0.254871401271736 no 848 0.274186879493873 1370 688960
SGTC_2506 ethyl hematommate 54.16 µM 0.599521876788135 0.255108230744242 no 849 0.274412463016318 1295 3940691 An allergen.
SGTC_513 4245-1575 41.7 µM 0.598897704619603 0.255326709358061 no 850 0.274620551108714 1319 719745
SGTC_1107 amlodipine 47 µM 0.598839429418275 0.255347112382963 no 851 0.274639983014167 1245 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1192 1488-0095 21.4 µM 0.598083016239348 0.2556120213173 no 852 0.274892271014582 1341 915875
SGTC_1550 gossypolone 36.6 µM 0.597310159529084 0.255882837237961 no 853 0.275150161368111 1331 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3090 9117696 49.47 µM 0.597168589129749 0.255932460996827 no 854 0.275197414131955 1386 7923821
SGTC_1494 4358-1428 177 µM 0.596132911970782 0.256295642916182 no 855 0.275543219511723 1415 1564571
SGTC_2164 5685496 200 µM 0.592959303261617 0.257410205961564 no 856 0.276604194189431 1344 759046
SGTC_2386 9075165 157.42 µM 0.592699371604366 0.257501604729448 no 857 0.276691181033798 1314 16452277
SGTC_1878 temozolomide 1 mM 0.592537704076973 0.257558459761466 no 858 0.276745290277079 1352 5394 DNA alkylating agent.
SGTC_3262 9137218 49.47 µM 0.592095707227348 0.25771393392801 no 859 0.276893250677926 1243 17650664
SGTC_250 brefeldin a 552.239 µM 0.59041057828698 0.258307131454925 no 860 0.277457710164747 1287 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_825 1988-2224 89.6 µM 0.590394350878314 0.258312847250155 no 861 0.277463148514373 1359 1180859
SGTC_834 0312-0008 75.7 µM 0.589776407940773 0.258530554626249 no 862 0.277670280706354 1366 6385573 YIL048W NEO1
SGTC_934 2950-0684 338 µM 0.587247114531668 0.259422639042853 no 863 0.278518876947923 1420 1121253
SGTC_999 SEC7.066 22.7 µM 0.586948738150561 0.25952798145823 no 864 0.278619067629913 1391 740511 YDR170C SEC7
SGTC_2255 7941087 197.44 µM 0.586578950312354 0.259658566485531 no 865 0.278743261646105 1422 935561
SGTC_1984 st072354 53.1 µM 0.586108494445309 0.259824749927384 no 866 0.278901304169917 1312 5762938
SGTC_2334 9017922 200 µM 0.585245963750583 0.260129572026614 no 867 0.279191171482208 1429 3163164
SGTC_2329 6138490 200 µM 0.58289946981621 0.260959765119643 no 868 0.27998048878381 1394 720019
SGTC_2372 9071633 200 µM 0.582846896994179 0.260978381056137 no 869 0.279998185696278 1383 21321366
SGTC_1030 k029-0042 36.7 µM 0.581991022141482 0.261281540736036 no 870 0.280286364083864 1414 6080581
SGTC_593 1203-0218 61.7 µM 0.581597709846839 0.261420916646911 no 871 0.280418842940422 1415 3666956
SGTC_3014 9081533 49.47 µM 0.581390479021802 0.261494367247417 no 872 0.280488656415476 1410 21367265
SGTC_2828 7998861 71.43 µM 0.581360942924972 0.261504836842435 no 873 0.280498607442306 1336 2988188
SGTC_3266 9136860 49.47 µM 0.580269268205583 0.261891951286876 no 874 0.280866524150594 1306 4871271 YPR165W RHO1
SGTC_3012 9080433 71.4286 µM 0.579494179055589 0.262166980865502 no 875 0.281127886589401 1394 17688859
SGTC_354 2783-3500 4.88 µM 0.577190087985662 0.262985428432288 no 876 0.281905526094542 1325 6740761
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.575406805339199 0.263619772454235 no 877 0.282508101346306 1442 23847180
SGTC_313 3474-0040 5.03 µM 0.57458676055752 0.263911738162514 no 878 0.282785404062691 1325 1043375 YIL048W NEO1
SGTC_690 glyoxal 20.3 µM 0.573458748566248 0.264313620511436 no 879 0.28316706111343 1283 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1401 3807-4679 7.6 µM 0.57244151123474 0.264676303629141 no 880 0.283511449911224 1381 3291456
SGTC_475 α-linolenic acid 10 µM 0.571192384200161 0.265122010055234 no 881 0.283934620053669 1453 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_587 k089-0003 57 µM 0.570339724231503 0.265426470119994 no 882 0.284223651455806 1351 9659696
SGTC_913 3487-1245 167 µM 0.570295734464655 0.265442182397128 no 883 0.284238566753032 1321 4016153
SGTC_3176 9106582 49.47 µM 0.568164991159864 0.266203806518044 no 884 0.284961470369821 1313 17018027
SGTC_647 0140-0236 81 µM 0.568049716684312 0.26624504235725 no 885 0.285000604873002 1417 990837
SGTC_1633 st005664 67.9 µM 0.567895025191969 0.266300383481972 no 886 0.285053125076314 1375 2063822
SGTC_1148 3909-7663 27.7 µM 0.567122284735844 0.266576919745221 no 887 0.285315551733974 1438 4084526
SGTC_754 3474-0146 171 µM 0.563962749953733 0.2677091132459 no 888 0.286389741649264 1316 24762078
SGTC_540 1187-0821 17.3 µM 0.562939823976705 0.268076189005431 no 889 0.286737930555067 1372 847520
SGTC_1468 k284-1086 134 µM 0.562728049704229 0.268152215592929 no 890 0.286810040459111 1398 15996457
SGTC_2045 5106652 78.05 µM 0.561196156749824 0.268702485373811 no 891 0.287331911323953 1410 673349
SGTC_605 1315-0399 119 µM 0.560362103278089 0.269002323259312 no 892 0.28761623757374 1446 24020461
SGTC_960 1222-0186 7.7 µM 0.560263009531961 0.269037958104504 no 893 0.287650027162114 1453 3126296
SGTC_2872 9044037 25.97 µM 0.559875027633577 0.269177502063254 no 894 0.28778234163963 1420 6465195
SGTC_957 1187-1561 14.1 µM 0.559660151555481 0.269254801337478 no 895 0.287855633757402 1369 1538454
SGTC_47 0149-0135 24.25 µM 0.558994347620293 0.269494387556898 no 896 0.288082788893645 1310 5239155
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.558147649148922 0.269799222028837 no 897 0.288371782712944 1418 688798
SGTC_2399 5884133 200 µM 0.556013720361435 0.270568259526141 no 898 0.289100737676815 1389 722445
SGTC_720 r052-1644 49.9 µM 0.554895600678403 0.270971650650298 no 899 0.289483035592951 1389 1422863 YOR257W CDC31
SGTC_2324 6149169 200 µM 0.554866741223812 0.270982066429533 no 900 0.289492906113224 1351 2888231
SGTC_835 0312-0010 67.2 µM 0.554052580843182 0.27127599053023 no 901 0.28977143062365 1373 1626196
SGTC_74 000s-0487 160.283 µM 0.553456121977843 0.271491421926105 no 902 0.28997555914351 1320 677548
SGTC_1471 k673-0312 37 µM 0.5532702253803 0.271558582216262 no 903 0.290039193063206 1394 24099884
SGTC_1621 st003705 32.4 µM 0.553141734221107 0.271605008038533 no 904 0.290083180459288 1473 24207032
SGTC_2738 aclarubicin 5.55 µM 0.55274087472348 0.271749870102191 no 905 0.290220429954838 1395 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1180 1193-0155 285 µM 0.551433592793239 0.272222560909288 no 906 0.290668238890581 1384 2921347
SGTC_212 3807-4682 38.772 µM 0.551222655101461 0.272298870642469 no 907 0.290740525789305 1516 3125501 YBL034C STU1
SGTC_1847 st056231 15 µM 0.54903424302488 0.273091186635593 no 908 0.291490975133734 1418 5393180
SGTC_3323 9138564 53.9225 µM 0.548638668203445 0.273234526594699 no 909 0.29162672183873 1498 43912313 YNL103W MET4
SGTC_2279 7948423 32.93 µM 0.548533481888232 0.273272648038314 no 910 0.291662822866461 1541 1247112
SGTC_2288 7946289 167.31 µM 0.546490446941819 0.274013603362601 no 911 0.292364426324289 1524 1246052
SGTC_3018 9082602 49.47 µM 0.545602974340852 0.274335775483858 no 912 0.292669439686869 1403 17332089
SGTC_1132 3456-3614 2.5 µM 0.544019116514426 0.274911215084002 no 913 0.293214159015128 1604 3125502
SGTC_846 0335-0850 148 µM 0.542727687722294 0.275380850576386 no 914 0.293658653908311 1398 6819598
SGTC_2421 5690543 90.72 µM 0.541326443085158 0.275890867376171 no 915 0.294141298663425 1452 3397993
SGTC_2764 methyldopa 94.69 µM 0.540930597570804 0.276035028916585 no 916 0.29427771008043 1515 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2063 5246145 200 µM 0.540678611910208 0.276126817922914 no 917 0.294364561500047 1465 711240
SGTC_3192 9110362 49.47 µM 0.540512856361381 0.276187204674298 no 918 0.294421698603173 1487 16649480
SGTC_2857 9024691 58.44 µM 0.540257120118905 0.276280385193155 no 919 0.294509862725828 1441 16478292
SGTC_1224 0823-0416 294 µM 0.540059980571611 0.276352225841102 no 920 0.294577834169825 1490 3598164
SGTC_1512 0259-0544 12.2 µM 0.539166558322096 0.276677917309904 no 921 0.294885966555998 1433 18476
SGTC_833 3852-0053 558 µM 0.537941255065092 0.277124899566781 no 922 0.295308802775552 1495 3123681
SGTC_38 0929-0051 58.268 µM 0.537566536598145 0.277261664822768 no 923 0.295438168934571 1499 1379719
SGTC_1924 st058459 75.1 µM 0.537200590528487 0.277395260172053 no 924 0.295564531703349 1404 688683
SGTC_2972 9093619 59.92 µM 0.535710947038697 0.277939406523332 no 925 0.296079168347713 1375 25236256
SGTC_2103 5378138 10 µM 0.535266568726523 0.278101832653959 no 926 0.296232770158574 1475 244142
SGTC_597 k018-0003 82.8 µM 0.535140036354091 0.278148090371482 no 927 0.296276513454399 1529 6786234
SGTC_656 4090-1979 187 µM 0.533890091073147 0.278605247018227 no 928 0.296708789032753 1499 22330961
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.530951253355878 0.279681540791914 no 929 0.297726279726161 1494 688751
SGTC_3072 9116419 49.47 µM 0.530165009764915 0.279969829406722 no 930 0.297998764337236 1388 17170162
SGTC_1246 0422-0085 105 µM 0.530069133497733 0.280004993805818 no 931 0.298031999481836 1462 264295
SGTC_1871 st057448 67.3 µM 0.529744826634733 0.280123955230505 no 932 0.298144431745042 1516 691747
SGTC_52 0329-0193 875 nM 0.529431810665237 0.280238798181558 no 933 0.298252967947467 1516 3739292
SGTC_1029 k015-0030 64.7 µM 0.529160837441396 0.280338234414415 no 934 0.298346940634469 1481 2208316
SGTC_1419 3993-2473 62.6 µM 0.528912542639623 0.280429363580483 no 935 0.298433060345087 1478 704026
SGTC_659 k018-0002 107 µM 0.528373823609163 0.280627133555802 no 936 0.298619951017475 1470 6797879 YHR007C ERG11
SGTC_2075 5212009 200 µM 0.527980980736901 0.280771393241504 no 937 0.298756268349826 1460 780898
SGTC_1423 4048-0112 5.59 µM 0.526415557021849 0.281346603754003 no 938 0.299299754485277 1505 X1423
SGTC_1526 st051518 75 µM 0.525874305804049 0.281545617227408 no 939 0.299487771176659 1449 673993
SGTC_933 2914-0560 114 µM 0.52239817520299 0.282825376793721 no 940 0.300696563137289 1587 463887
SGTC_3002 9075603 71.4286 µM 0.52140784954778 0.283190482211602 no 941 0.301041342227459 1425 20105405
SGTC_2345 9052315 157.45 µM 0.521116531207453 0.283297926174202 no 942 0.301142797795659 1470 6469265
SGTC_2933 9026794 32.47 µM 0.519314060241988 0.283963147418928 no 943 0.301770875035455 1510 17586027
SGTC_1634 st006576 41 µM 0.519134146493622 0.284029587523091 no 944 0.301833598912631 1559 3915356
SGTC_2435 5706476 10.6 µM 0.518729254596673 0.284179136698074 no 945 0.301974779031968 1503 5725375
SGTC_1507 4075-3230 155 µM 0.518253277428309 0.284354989764331 no 946 0.302140783507809 1392 659771
SGTC_169 k015-0017 16.025 µM 0.517678446735939 0.284567434251558 no 947 0.302341319288666 1540 1840002
SGTC_1684 st024538 14.6195 µM 0.517204424556303 0.284742679184946 no 948 0.302506731854709 1455 6732859
SGTC_3025 9087895 49.47 µM 0.516611074384466 0.284962111970632 no 949 0.302713841715104 1491 17173641
SGTC_1618 st003135 44.5 µM 0.516425376530321 0.285030803324943 no 950 0.302778672906739 1436 1270615
SGTC_2249 haloperidol 116.36 µM 0.516119800085673 0.285143856061522 no 951 0.302885369875243 1482 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2426 5582046 32.21 µM 0.515532115878696 0.285361338989135 no 952 0.303090616640345 1497 2251934
SGTC_2925 9010536 32.5 µM 0.515321891855649 0.285439155285221 no 953 0.303164051790491 1545 2994177
SGTC_2619 obliquin 87.91 µM 0.515237728069342 0.28547031209308 no 954 0.30319345399229 1492 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1342 1486-1464 234 µM 0.513421656306567 0.286143002455792 no 955 0.303828199996129 1460 3253938
SGTC_2128 5255449 168.493 µM 0.513363052319002 0.286164722469378 no 956 0.303848692893439 1419 736008
SGTC_568 1193-0097 7.48 µM 0.511280884852204 0.286936930337843 no 957 0.304577193978661 1402 3646150
SGTC_3021 9087658 49.47 µM 0.511025573390738 0.287031684920389 no 958 0.304666574865924 1468 25237042
SGTC_2474 5321570 43.32 µM 0.510317066328314 0.287294713073165 no 959 0.304914674118993 1527 2841384
SGTC_2207 7258803 200 µM 0.509339847052376 0.287657685730876 no 960 0.305257016029025 1494 3666799
SGTC_977 1348-1378 135 µM 0.508511613553663 0.287965489558433 no 961 0.305547298319236 1438 X977
SGTC_2608 thymoquinone 42.66 µM 0.506690596519381 0.288642796648197 no 962 0.30618596478631 1406 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2686 alizarin 95.37 µM 0.505981593536583 0.288906705240245 no 963 0.306434785612578 1441 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_193 1273-0060 1.558 µM 0.503302801714218 0.289904841950274 no 964 0.307375698470465 1407 2847393 YHR072W ERG7
SGTC_542 3381-0244 89.3 µM 0.501161351984092 0.290703922544575 no 965 0.308128785740124 1572 1112843
SGTC_3140 9094243 49.47 µM 0.500888093045252 0.290805963007193 no 966 0.308224941407921 1463 19291112
SGTC_128 0906-2981 13.371 µM 0.499793786688609 0.291214767036817 no 967 0.308610143025259 1544 6740226
SGTC_1330 1469-0054 61.8 µM 0.499208425396153 0.291433552682345 no 968 0.308816279825897 1595 7102664
SGTC_1756 st041558 35.5 µM 0.497780479228581 0.291967585730273 no 969 0.309319388142394 1664 3955792
SGTC_845 0330-0138 4.51 µM 0.497049531443701 0.292241126777106 no 970 0.309577061475973 1555 9039800
SGTC_1521 st012942 49.4 µM 0.496353569515963 0.292501685883071 no 971 0.309822488633809 1658 24207259
SGTC_3202 9113761 49.47 µM 0.496290741271997 0.292525213274153 no 972 0.309844648843906 1645 4798415
SGTC_3144 9087057 49.47 µM 0.495288093438343 0.292900795331864 no 973 0.310198387179676 1552 17249618
SGTC_283 0987-0079 11.7 µM 0.493225059264136 0.293674290914032 no 974 0.310926786656337 1532 411556
SGTC_2782 7736369 71.43 µM 0.491681961109001 0.294253463684725 no 975 0.311472096211921 1500 2950836 YOL077C BRX1
SGTC_2646 retinol 96.75 µM 0.489190060153432 0.295189863964223 no 976 0.312353572995594 1509 445354 A vitamin A analog and teratogen.
SGTC_2895 9054447 58.44 µM 0.489166092355514 0.295198877180698 no 977 0.312362056512112 1508 2697450
SGTC_1666 st014829 29 µM 0.488817303454224 0.295330055416506 no 978 0.31248552326278 1476 3858230
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.488266542402014 0.295537249244104 no 979 0.312680528400401 1672 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1569 carminic acid 40.6 µM 0.488076592124743 0.295608723181005 no 980 0.312747795285428 1548 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_865 0488-0499 301 µM 0.486460301812088 0.296217217400496 no 981 0.313320422537992 1509 9634651
SGTC_883 0850-0245 24.6 µM 0.486420066673757 0.296232372283894 no 982 0.313334682990427 1576 6823229 YPR165W RHO1
SGTC_3213 9129884 49.47 µM 0.48599781419991 0.296391438466993 no 983 0.313484357845516 1390 17190742
SGTC_1685 st024049 53.0905 µM 0.48512315970654 0.296721052919412 no 984 0.313794492289225 1499 1941139
SGTC_92 0063-0024 660.874 µM 0.483082038539825 0.297490903635381 no 985 0.314518743420065 1512 3594437
SGTC_1434 4073-0095 163 µM 0.482345658913661 0.297768868015854 no 986 0.314780208543065 1515 24133745
SGTC_1011 4112-3381 17.4 µM 0.481958876261448 0.297914915965017 no 987 0.314917580047985 1545 2877139
SGTC_2014 4013930 200 µM 0.480569892743864 0.298439660921005 no 988 0.31541110882903 1469 64556
SGTC_2640 pentamidine 10.38 µM 0.479509475642716 0.298840559460593 no 989 0.315788114406955 1578 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_330 1488-0319 80.1 µM 0.478528184240397 0.2992117617872 no 990 0.316137159589888 1522 6846614
SGTC_282 k297-0036 65.7 µM 0.476614072292504 0.299936432328579 no 991 0.316818480423796 1529 5061378
SGTC_15 0266-0086 27.098 µM 0.476518728410529 0.299972549672154 no 992 0.316852433989129 1573 1712902 YIL048W NEO1
SGTC_2065 5221596 34.26 µM 0.473629510274802 0.301067950316179 no 993 0.317882063883995 1555 788581
SGTC_2655 perillic acid 100 µM 0.473597524813633 0.301080087173985 no 994 0.317893470437349 1491 5702197 An apoptosis inducer.
SGTC_2908 7930301 100 µM 0.473327840814803 0.301182427318939 no 995 0.317989651155956 1414 2223178
SGTC_2010 4012422 159 µM 0.472199104118208 0.301610932204708 no 996 0.31839233956882 1566 952393
SGTC_176 1486-1328 72.834 µM 0.470165831262172 0.302383519251805 no 997 0.319118271964775 1501 22310231
SGTC_981 1488-1094 54.9 µM 0.469319502914655 0.302705361859071 no 998 0.319420638434867 1488 3449522
SGTC_2232 chlorophetanol 41.5365 µM 0.467956343819391 0.303224067750782 no 999 0.319907904741251 1619 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_69 0096-0274 206.684 µM 0.467907493808148 0.303242663408899 no 1000 0.319925372135112 1603 6741392
SGTC_642 0335-0876 158 µM 0.465599774302984 0.304121719679348 no 1001 0.320751002278107 1564 6812350
SGTC_182 3448-4371 550.524 µM 0.465459828489286 0.3041750643252 no 1002 0.320801099110021 1650 3491403
SGTC_11 0438-0307 1.3 µM 0.465148159279929 0.304293881595719 no 1003 0.320912680017928 1621 4011476
SGTC_411 enrofloxacin 100 µM 0.464979151009508 0.304358321052964 no 1004 0.320973193550283 1692 71188 A bacterial gyrase inhibitor.
SGTC_2404 5161160 200 µM 0.464753606616439 0.304444326060173 no 1005 0.321053957289658 1577 2831543
SGTC_1531 st059297 52.4 µM 0.463418438746846 0.304953676131874 no 1006 0.321532232250135 1539 7566702
SGTC_2576 guaiol 23.12 µM 0.463361028256361 0.30497558601206 no 1007 0.32155280409716 1677 227829
SGTC_107 0358-0022 2.6945 µM 0.463335060340113 0.304985496519937 no 1008 0.321562109335903 1608 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_773 4358-1457 44.6 µM 0.461357792683016 0.305740529170732 no 1009 0.322270963936772 1682 1186886
SGTC_1331 1472-0049 76.2 µM 0.460894500804368 0.305917559862815 no 1010 0.322437148676762 1505 24051409
SGTC_838 0109-0203 71.4 µM 0.459008926803521 0.306638533201291 no 1011 0.323113877829965 1525 759422
SGTC_1571 st070080 73.4 µM 0.458657898268538 0.306772836217876 no 1012 0.323239926099977 1641 4315245
SGTC_548 1436-0017 110 µM 0.458418776944885 0.306864338551942 no 1013 0.323325802050131 1656 9677137
SGTC_1834 st055981 52.8 µM 0.458151844268862 0.306966497412635 no 1014 0.323421677047129 1630 471719 YDL150W RPC53
SGTC_1906 st060206 94.7 µM 0.458078976349843 0.306994387587048 no 1015 0.323447851270243 1627 5133468
SGTC_2332 7982454 138.89 µM 0.457429990919053 0.307242835825064 no 1016 0.323681005959816 1516 2981748
SGTC_3278 9139605 49.47 µM 0.456451080699736 0.307617755117932 no 1017 0.324032820457115 1606 7958859
SGTC_1699 st031318 29.054 µM 0.456341545283497 0.307659719323075 no 1018 0.324072196618889 1600 5340658
SGTC_2000 st075254 36.4 µM 0.455745270982286 0.307888202598658 no 1019 0.324286581832002 1519 17234175
SGTC_2401 5128683 200 µM 0.455018243278557 0.308166889395302 no 1020 0.324548057115457 1465 708373
SGTC_2294 7971431 200 µM 0.454021456383547 0.308549161027489 no 1021 0.324906691803336 1546 5741572
SGTC_539 4859-0462 2.54 µM 0.452935373974563 0.308965914187249 no 1022 0.32529763898746 1658 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1295 1013-0063 9.78 µM 0.451738239155371 0.309425565610736 no 1023 0.325728783554458 1650 6826038
SGTC_1889 st059080 5.18 µM 0.447804592677999 0.310938024740839 no 1024 0.327147114289931 1688 176925 Isolated from Daphnopsis sellowiana.
SGTC_279 1273-0055 2.93 µM 0.446587846223726 0.311406504176392 no 1025 0.327586336264762 1614 2847562
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.446259839977305 0.311532847540985 no 1026 0.327704781060294 1560 1241132 A phosphatase inhibitor.
SGTC_3240 9133527 49.47 µM 0.44463123336753 0.312160492213488 no 1027 0.328293136116486 1545 17617455
SGTC_1028 k015-0029 4.8 µM 0.444236126492535 0.312312843782402 no 1028 0.328435937838901 1532 4588309
SGTC_1791 st048313 56.1 µM 0.444014521809428 0.31239830767761 no 1029 0.328516042408505 1657 1204976
SGTC_1794 st048918 76.9 µM 0.441185961198431 0.313490053490981 no 1030 0.329539187878315 1627 672303
SGTC_1606 st000094 49.2 µM 0.438718101204927 0.314443915854133 no 1031 0.330432904745786 1693 1242210
SGTC_1390 3413-2614 145 µM 0.438489844586227 0.314532202974972 no 1032 0.330515615138284 1584 3421432
SGTC_2338 7999974 200 µM 0.437987826699037 0.314726415221174 no 1033 0.330697553975381 1699 315925
SGTC_438 sphingosine 6.67 µM 0.437759163927255 0.314814893428027 no 1034 0.330780438069212 1416 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1725 st036284 20.55 µM 0.43670297345274 0.315223711051905 no 1035 0.331163386274991 1729 707914
SGTC_221 trifluoperazine 10.304 µM 0.436549265842912 0.315283225243638 no 1036 0.33121913153821 1558 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3135 9127742 49.47 µM 0.434774458880352 0.315970761304043 no 1037 0.331863072903201 1563 3643468
SGTC_134 0269-0018 6.916 µM 0.433835047578959 0.316334934454326 no 1038 0.332204114526256 1514 4378915
SGTC_111 0083-0039 52.457 µM 0.433728251771892 0.316376346313458 no 1039 0.332242894224661 1543 759313
SGTC_2015 5119600 184 µM 0.431752570735876 0.317142864540441 no 1040 0.332960627235794 1689 2828786
SGTC_3105 9121040 49.47 µM 0.431634333139569 0.317188762907463 no 1041 0.333003600492114 1521 41448907
SGTC_2478 5763493 32.33 µM 0.430159099371077 0.317761666584156 no 1042 0.333539955969991 1632 1365576 YLR208W SEC13
SGTC_815 1582-0027 36.9 µM 0.429936667594398 0.317848085366682 no 1043 0.33362085576636 1649 3128206
SGTC_2721 ifenprodil 61.44 µM 0.429329142330909 0.318084170507258 no 1044 0.333841855831901 1662 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1015 4130-4525 82 µM 0.428955757373156 0.318229305099242 no 1045 0.333977711055544 1530 1363237
SGTC_1136 pergolide 1.05886 µM 0.428255484683965 0.318501576073738 no 1046 0.334232562263361 1590 47811 A dopamine receptor agonist.
SGTC_2351 9026858 72.31 µM 0.427939357214993 0.318624520799547 no 1047 0.33434763601916 1503 1409300
SGTC_2436 5633522 8.09 µM 0.426252776013976 0.319280784130304 no 1048 0.334961832357201 1697 5724242
SGTC_459 nigericin 15.3 µM 0.426217797758413 0.319294400476416 no 1049 0.334974574945665 1608 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2180 6301957 200 µM 0.425631500441695 0.319522670746618 no 1050 0.335188191494316 1646 845462
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.424854121041489 0.319825442798485 no 1051 0.335471510712633 1549 2374 Ca(2+)-ATPase inhibitor.
SGTC_762 1165-0429 115 µM 0.424791897348575 0.319849682741355 no 1052 0.335494192448523 1682 5967793
SGTC_3301 9125354 19.7965 µM 0.42439844533609 0.320002974228372 no 1053 0.335637627171805 1555 41905162
SGTC_1464 k208-0027 110 µM 0.423370904235913 0.320403455890409 no 1054 0.336012334876425 1678 X1464
SGTC_2516 gossypol 71.55 µM 0.421830091514773 0.321004375949221 no 1055 0.336574519941144 1718 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3063 1327-0034 4 µM 0.421543564529794 0.32111617382604 no 1056 0.336679103284085 1591 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1698 5-fluorocytosine 1.055 µM 0.421275515890877 0.321220776452998 no 1057 0.33677695340373 1696 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3352 9151559 45.5865 µM 0.421073110589007 0.321299771989175 no 1058 0.336850847999506 1547 17159339
SGTC_2682 pyrogallin 40.03 µM 0.41915178281249 0.322050037550546 no 1059 0.337552604081763 1628 822798 An ATP competetive kinase inhibitor.
SGTC_2413 inermin 26.06 µM 0.418791526359338 0.322190796167649 no 1060 0.337684249092378 1743 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_487 nimodipine 119 µM 0.417135645860653 0.322838105968151 no 1061 0.33828959664641 1663 4497 L-type voltage-gated calcium channels inhibitor
SGTC_229 benomyl 22.8748 µM 0.41663129450956 0.323035371667888 no 1062 0.338474057763641 1578 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3222 9128301 49.47 µM 0.416574700544664 0.323057510233472 no 1063 0.338494758821229 1587 4911358
SGTC_443 clozapine 122 µM 0.41631980410655 0.323157229013963 no 1064 0.33858800141623 1674 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1552 6-methylflavone 10.6 µM 0.415566530846041 0.323451993502699 no 1065 0.33886361095396 1683 689013
SGTC_3104 9120930 49.47 µM 0.414789901330479 0.323756013609191 no 1066 0.339147856480047 1611 17014836
SGTC_501 nsc-95397 161 µM 0.414112830995146 0.324021156185084 no 1067 0.339395738186856 1672 262093
SGTC_361 000s-0510 1.45 µM 0.413699527051589 0.324183051030468 no 1068 0.339547086752976 1607 660
SGTC_1854 st056233 32.9 µM 0.412528512362236 0.324641928421095 no 1069 0.339976043345367 1723 5393174
SGTC_632 0781-2353 4.65 µM 0.411032095463702 0.32522870646095 no 1070 0.340524500232468 1642 6811515 YHR007C ERG11
SGTC_2893 9048488 25.97 µM 0.410940783833547 0.325264525814609 no 1071 0.340557978105135 1543 6467338
SGTC_1936 st074407 74.3 µM 0.410559874796488 0.325413964668902 no 1072 0.34069764554175 1570 809813
SGTC_1607 st000305 50.6 µM 0.409466083800143 0.325843238518379 no 1073 0.341098825870186 1658 5457690
SGTC_1498 4478-3555 97.6 µM 0.4086014103755 0.326182755429557 no 1074 0.341416097736765 1667 3437919
SGTC_1825 st052143 62.6 µM 0.408580433220971 0.326190993971044 no 1075 0.341423796211032 1674 674173
SGTC_1325 1431-0015 227 µM 0.408487823975315 0.326227366224378 no 1076 0.341457783968359 1528 1103340
SGTC_3157 9099274 49.47 µM 0.408095425023119 0.326381499130489 no 1077 0.34160180934253 1705 17217662
SGTC_1810 st050138 53 µM 0.407366028037296 0.326668082430155 no 1078 0.341869587112929 1708 3444541
SGTC_3344 9148862 3.898 µM 0.40625905767907 0.327103211390737 no 1079 0.342276132411084 1689 4905352
SGTC_2150 5556613 200 µM 0.406234017814677 0.327113056806005 no 1080 0.342285330653947 1635 743190
SGTC_451 chloral hydrate 100 µM 0.405596080741971 0.327363927615673 no 1081 0.342519704526289 1656 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1932 st074806 40.9 µM 0.405065432651075 0.327572666112593 no 1082 0.34271470734597 1687 17251235
SGTC_2257 7960413 200 µM 0.404830699195347 0.327665019288587 no 1083 0.342800980686686 1699 2974689 YIL048W NEO1
SGTC_100 0086-0128 49.5915 µM 0.403865133076504 0.328045021000805 no 1084 0.343155948598678 1525 93297
SGTC_891 0929-0073 133 µM 0.403685174973594 0.328115863799359 no 1085 0.343222121321784 1679 5603632
SGTC_1715 st032160 10.2275 µM 0.403575853233334 0.328158902713584 no 1086 0.343262322566181 1703 5289825
SGTC_543 3844-1095 191 µM 0.403562662932588 0.328164095761953 no 1087 0.343267173198935 1701 4230703
SGTC_2940 9060638 45.86 µM 0.402998303614755 0.328386316277183 no 1088 0.343474736221879 1628 4027022
SGTC_2641 levomentholum 100 µM 0.401282964474303 0.329062115855281 no 1089 0.344105902225922 1636 16666
SGTC_2783 7738165 71.43 µM 0.400776747750251 0.329261659185012 no 1090 0.344292249849072 1518 17201110
SGTC_2914 7968218 45.32 µM 0.399935366217221 0.329593427247655 no 1091 0.344602061389606 1713 2977111
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.398491766861066 0.330162970357493 no 1092 0.34513386298815 1612 688667
SGTC_142 0335-0849 62.6745 µM 0.398439699870588 0.330183519707167 no 1093 0.345153049454718 1654 3889043 YPR107C YTH1
SGTC_3336 9143619 71.43 µM 0.395747232230986 0.331246856485896 no 1094 0.346145753910582 1687 45595730
SGTC_894 0960-0238 55.9 µM 0.395360711932011 0.33139961702912 no 1095 0.346288349756389 1659 6741907 YDL195W SEC31
SGTC_322 k048-0136 19.3 µM 0.39456446895659 0.331714396561713 no 1096 0.346582169982749 1647 6823282
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.394455824934139 0.331757356132178 no 1097 0.346622267684791 1587 4174840
SGTC_2238 6671620 73.2395 µM 0.39434480974368 0.331801255585587 no 1098 0.346663242298788 1546 729941
SGTC_3064 1327-0027 10 µM 0.394177674789267 0.331867351195448 no 1099 0.346724933548353 1592 16000455 YPR107C YTH1
SGTC_710 3448-4187 58 µM 0.391946545434782 0.332750179740497 no 1100 0.347548855291483 1638 3946412
SGTC_1799 st045822 46.1415 µM 0.391704468967964 0.332846022116885 no 1101 0.347638293815388 1746 3674992
SGTC_2730 imipramine 71.33 µM 0.391369066384298 0.33297883201219 no 1102 0.347762226988671 1696 3696 A tricyclic antidepressant.
SGTC_377 3970-0964 33.1 µM 0.391346427951864 0.332987796943403 no 1103 0.347770592605206 1697 16481235
SGTC_3068 9116768 49.47 µM 0.390808048987488 0.33320102579516 no 1104 0.347969562485962 1626 41904888
SGTC_2293 7624732 200 µM 0.390366235950794 0.333376049307504 no 1105 0.348132875566927 1567 894453
SGTC_1534 6-azauridine 81.6 µM 0.389671794335389 0.333651224543058 no 1106 0.348389627948662 1641 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_429 1112-0049 25.5 µM 0.38879919544476 0.333997122194964 no 1107 0.348712348019588 1576 2836170
SGTC_2563 tomatine 8.54 µM 0.386403761216447 0.334947395287597 no 1108 0.349598832492417 1904 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3074 9116018 49.47 µM 0.386229153940398 0.335016703739932 no 1109 0.349663482005799 1669 17027303
SGTC_2250 alverine citrate 130 µM 0.38459435370627 0.335665892144168 no 1110 0.350268989025945 1618 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_567 1080-0542 68.4 µM 0.383275136300841 0.336190118771137 no 1111 0.350757886315619 1734 5950415
SGTC_1303 1160-0052 261 µM 0.382436603382854 0.336523498197863 no 1112 0.351068772218137 1672 3562476
SGTC_2736 butenafine 14.65 µM 0.382290887145308 0.33658144439627 no 1113 0.351122806657067 1738 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_468 gf-109203x 121 µM 0.381717938028937 0.336809323630548 no 1114 0.351335296604304 1732 2396 A protein kinase C inhibitor.
SGTC_161 4065-0411 162.148 µM 0.380495684365698 0.337295651149641 no 1115 0.351788749733803 1710 1906281 YLR208W SEC13
SGTC_2890 9046729 58.44 µM 0.378371504687624 0.338141496417104 no 1116 0.352577316716653 1596 903329
SGTC_1493 4348-0038 111 µM 0.377710729184099 0.338404783205737 no 1117 0.352822748259074 1705 800424
SGTC_1833 st055984 71 µM 0.377407153236088 0.338525769903932 no 1118 0.352935525878069 1678 676288
SGTC_1137 ixabepilone 100 µM 0.376642849035464 0.33883044832803 no 1119 0.353219519959653 1597 154225 A novel microtubule stabilizer.
SGTC_428 3448-4153 16.5 µM 0.376580172263179 0.338855438166759 no 1120 0.353242812526091 1591 3834874
SGTC_2651 TUB2.036 5 µM 0.374720250262772 0.339597329541947 no 1121 0.35393426514741 1734 15992207 YFL037W TUB2
SGTC_1360 1598-0022 39.8 µM 0.374507514545504 0.339682225905689 no 1122 0.354013383456534 1758 761525
SGTC_2700 st077718 96.8 µM 0.37335898087634 0.340140711216848 no 1123 0.35444064217172 1631 904970
SGTC_2355 9061122 103.12 µM 0.37321003768499 0.340200185464586 no 1124 0.354496063015843 1775 5302957
SGTC_2453 5731132 22.18 µM 0.370609194739852 0.3412393632784 no 1125 0.355464316313082 1807 1362040
SGTC_1782 st039423 80.636 µM 0.370432503934235 0.341310004642422 no 1126 0.355530129482398 1611 2068169
SGTC_1842 st055362 61.2 µM 0.369740987257864 0.341586527947777 no 1127 0.355787744584068 1734 676032
SGTC_2090 5301565 104.445 µM 0.368779090594851 0.34197131205318 no 1128 0.35614619558451 1688 2056344
SGTC_27 0485-0001 32.618 µM 0.368229890084748 0.342191080446357 no 1129 0.356350912326844 1741 2054479
SGTC_291 SEC14.278 35.5 µM 0.367850085520502 0.342343094535101 no 1130 0.356492510256644 1761 1068044
SGTC_3 0833-0587 95.581 µM 0.366963587354196 0.342698008519913 no 1131 0.356823089567815 1693 5382644
SGTC_2605 digitonin 300 nM 0.36489691758355 0.34352594902002 no 1132 0.35759417765848 1797 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_570 0987-0065 62.6 µM 0.364037408812814 0.343870503225551 no 1133 0.357915037472987 1760 3104428
SGTC_471 1-acyl-paf 4 µM 0.363824085315437 0.343956039043926 no 1134 0.357994687983947 1619 16759367
SGTC_2073 5212005 126 µM 0.362381041042272 0.344534862640189 no 1135 0.358533652586017 1783 691789
SGTC_3260 9137109 49.47 µM 0.361706101073029 0.3448057148335 no 1136 0.358785833673129 1780 17478346
SGTC_1143 3454-2408 5.08 µM 0.361347023003925 0.344949844647171 no 1137 0.358920022848671 1683 X1143
SGTC_945 3381-0768 11.3 µM 0.361078214822794 0.345057755892344 no 1138 0.359020489136836 1748 1126236 YIL048W NEO1
SGTC_872 0588-0139 234 µM 0.360002774816257 0.345489610069876 no 1139 0.3594225292493 1677 2047100
SGTC_217 ketoconazole 989 nM 0.359883893828894 0.345537360332592 no 1140 0.35946698101795 1688 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1244 0416-0015 52.5 µM 0.358909995030964 0.345928633315732 no 1141 0.359831211094076 1686 96201
SGTC_2248 tofa 1.1 µM 0.358228008075423 0.346202725982231 no 1142 0.360086344384555 1715 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1640 st009078 66.4 µM 0.357596432558862 0.346456630006529 no 1143 0.360322674209119 1766 690618
SGTC_1439 4092-1168 46 µM 0.357568828300123 0.34646772895948 no 1144 0.360333004690279 1721 2886240
SGTC_390 dec-rvkr-cmk 16.7 µM 0.357035362708254 0.346682247448529 no 1145 0.360532666230938 1730 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1061 3448-9325 110 µM 0.352050887274022 0.34868898469074 no 1146 0.362400049850073 1748 723482
SGTC_1270 0831-1170 17.3 µM 0.351706105388496 0.348827950463979 no 1147 0.362529340662318 1692 6764716
SGTC_1627 st003713 25.6 µM 0.350658472667323 0.349250327565538 no 1148 0.362922291800259 1677 16195070 YER133W GLC7
SGTC_984 1492-0255 2.91 µM 0.349294548869392 0.349800504479256 no 1149 0.363434095212047 1727 1585198
SGTC_1346 1488-2224 62.4 µM 0.348492650253215 0.35012412015182 no 1150 0.363735116280599 1827 3722427
SGTC_2767 sibutramine 71.45 µM 0.347909914607622 0.350359358333453 no 1151 0.363953919554461 1826 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_488 nitrendipine 139 µM 0.347404558882606 0.350563406348172 no 1152 0.364143704443453 1757 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2391 6285546 200 µM 0.347009268978183 0.350723043032532 no 1153 0.364292177658435 1663 846083
SGTC_2528 xanthyletin 44.79 µM 0.346653140590331 0.350866887025241 no 1154 0.364425959018452 1687 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_347 4534-1311 26.2 µM 0.34663842092465 0.350872832912851 no 1155 0.364431488887967 1681 2862016
SGTC_760 0568-0725 82.9 µM 0.344534213267162 0.351723185374846 no 1156 0.365222285350944 1828 3916171
SGTC_1611 st001856 99.4 µM 0.344531702116325 0.351724200625524 no 1157 0.365223229426702 1671 647478
SGTC_168 3970-0862 530.542 µM 0.344094187537615 0.351901102580505 no 1158 0.365387726994683 1730 3135186
SGTC_2897 9048598 12.99 µM 0.344048990727717 0.351919379008626 no 1159 0.365404721589547 1691 6467404
SGTC_1371 2421-0008 32.7 µM 0.343333011903515 0.352208948055812 no 1160 0.365673974274284 1714 2827552
SGTC_2161 5662504 8.5105 µM 0.342918230918087 0.352376740468929 no 1161 0.36582998807967 1684 2859334
SGTC_2915 7971052 15.16 µM 0.342458569998897 0.352562721843148 no 1162 0.366002908739326 1746 5741558
SGTC_379 3970-0972 5.9 µM 0.342084928987993 0.352713925056978 no 1163 0.366143489475576 1745 2898042 YBL034C STU1
SGTC_1328 1441-0025 69.2 µM 0.34058413042 0.353321495105051 no 1164 0.366708339005741 1623 4562601
SGTC_102 gallobenzophenone 83.616 µM 0.339320549564662 0.353833322118618 no 1165 0.367184131836098 1803 70837
SGTC_2467 5474540 200 µM 0.338961886460277 0.353978650661997 no 1166 0.367319221211468 1687 5413519
SGTC_717 1532-0246 73.2 µM 0.338447883028264 0.354186959439136 no 1167 0.367512847683283 1703 9561992
SGTC_518 1021-0119 62.6 µM 0.338268548660825 0.354259648064145 no 1168 0.367580411349892 1652 1097762
SGTC_2205 7238770 200 µM 0.338131773487247 0.354315089971715 no 1169 0.367631943727455 1814 279867
SGTC_709 3807-1509 243 µM 0.337723196891001 0.354480725150751 no 1170 0.367785896113155 1731 1886677 YPL242C IQG1
SGTC_639 0833-0042 114 µM 0.337710022131724 0.354486066599221 no 1171 0.367790860739494 1675 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_141 0443-0274 32.331 µM 0.337372654264689 0.354622855549167 no 1172 0.367917998129612 1859 1627241
SGTC_578 3460-0051 92 µM 0.33718525941291 0.354698844641512 no 1173 0.367988624303851 1859 2876744
SGTC_2843 9000894 45.46 µM 0.33629526503699 0.355059818537254 no 1174 0.368324110086513 1690 2242070
SGTC_1265 0819-1001 68.8 µM 0.335551766857162 0.355361474640925 no 1175 0.368604450733434 1708 3106768
SGTC_2963 9082507 9 µM 0.334933411176054 0.355612426305486 no 1176 0.368837658902365 1768 16459611
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.334124071264988 0.355940981028115 no 1177 0.369142968304006 1730 5379071
SGTC_3094 9117742 49.47 µM 0.333136193364086 0.356342158970235 no 1178 0.369515739943685 1664 17149698
SGTC_1202 1988-0068 29.6 µM 0.329825815619032 0.357687662990037 no 1179 0.370765789927341 1649 2850480
SGTC_406 estrone 100 µM 0.328735292634595 0.358131294890025 no 1180 0.371177887951326 1853 5870 A steroid.
SGTC_631 k072-0230 41.5 µM 0.328623898415959 0.358176621584675 no 1181 0.371219991067523 1779 5773147
SGTC_3023 9089636 49.47 µM 0.327895301818149 0.35847313934035 no 1182 0.371495413071018 1819 17249241
SGTC_2699 st077704 54.6 µM 0.325447054676406 0.359470129490512 no 1183 0.37242137378615 1741 645852
SGTC_741 4582-0002 126 µM 0.325342139377743 0.359512875179497 no 1184 0.372461070721508 1707 2912688
SGTC_3264 9137442 49.47 µM 0.324258256901241 0.359954584728011 no 1185 0.372871259954977 1832 17015726
SGTC_9 0092-0002 10.449 µM 0.322855396351564 0.360526563621196 no 1186 0.373402378669518 1748 759368
SGTC_1453 4237-0541 195 µM 0.320511396240937 0.361482963167761 no 1187 0.374290346358209 1870 739892
SGTC_101 0490-5701 117.494 µM 0.320195977385931 0.361611726701982 no 1188 0.3744098861946 1841 4661669
SGTC_2359 9039622 200 µM 0.320076113111002 0.361660663041499 no 1189 0.374455316435523 1816 6463596
SGTC_1855 st056195 39.6 µM 0.320057298273812 0.361668344678839 no 1190 0.374462447680923 1864 4028379
SGTC_2025 5147754 141 µM 0.319430166331614 0.361924419174597 no 1191 0.37470016931336 1840 315777 YLR208W SEC13
SGTC_1787 fluconazole 80 µM 0.318163130550219 0.362441971811871 no 1192 0.375180599140366 1753 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2891 9063876 19.48 µM 0.316816332507085 0.362992381101065 no 1193 0.375691485291075 1912 6472478
SGTC_1292 0kpi-0043 232 µM 0.316180208376401 0.363252450762176 no 1194 0.375932864600045 1739 3333905
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.315317225660714 0.363605368878173 no 1195 0.376260403712543 1738 91467 include heat shock
SGTC_3261 9137475 49.47 µM 0.314823430028504 0.363807359460659 no 1196 0.376447860534034 1778 17027690
SGTC_3168 9103419 49.47 µM 0.31349186338011 0.364352234711519 no 1197 0.376953500732352 1841 16649256
SGTC_2154 5570129 200 µM 0.3124375422997 0.364783856056425 no 1198 0.377354011353343 1787 673366
SGTC_2591 skatole 100 µM 0.312370720531557 0.364811217548699 no 1199 0.377379399748698 1754 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2144 5628481 200 µM 0.310809383750983 0.365450733449106 no 1200 0.377972767783611 1764 2818399
SGTC_2567 aureobasidin a 60 nM 0.310576911871234 0.365545984845021 no 1201 0.378061140706371 1797 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_39 0986-0283 58.349 µM 0.310370318731308 0.365630639826788 no 1202 0.378139681321708 1894 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_58 0957-0393 9 µM 0.309955981908051 0.365800440966792 no 1203 0.378297215130813 1748 6997992
SGTC_2667 digitoxin 100 µM 0.306677099940992 0.367145098484013 no 1204 0.379544580992675 1882 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2545 solidagenone 89.61 µM 0.306614812698173 0.367170658094102 no 1205 0.379568288748155 1769 6708572 An anti ulcer agent
SGTC_893 0958-0369 48.9 µM 0.30588453141716 0.367470373369641 no 1206 0.379846281986869 1910 6819948
SGTC_3032 9089427 49.47 µM 0.305618880480318 0.367579419404137 no 1207 0.379947421672842 1755 17173707
SGTC_1859 st055998 20 µM 0.305420817504483 0.367660728464206 no 1208 0.380022834344208 1921 676301
SGTC_2227 7312221 64.1025 µM 0.305117223530637 0.36778537175522 no 1209 0.380138436900842 1841 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_718 1130-0073 349 µM 0.304584768954093 0.368004009487051 no 1210 0.38034121088552 1833 6740020
SGTC_584 0986-0246 15.4 µM 0.304448087163867 0.368060140981513 no 1211 0.380393268541006 1843 53315 YDR232W HEM1
SGTC_196 k015-0023 18.111 µM 0.30377759069855 0.368335536432236 no 1212 0.380648670233749 1764 5211998
SGTC_2117 5521686 200 µM 0.303613650240272 0.368402882592077 no 1213 0.380711125418369 1732 803312
SGTC_2233 sulbentine 40.3845 µM 0.303148876679129 0.368593831898386 no 1214 0.380888203661203 1794 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_761 k216-0224 480 µM 0.303053020768443 0.36863321773704 no 1215 0.380924727768172 1951 1340404
SGTC_2283 7944793 200 µM 0.302157855432652 0.369001095087797 no 1216 0.38126586500311 1707 2970533
SGTC_1752 st044819 83.042 µM 0.301773926788354 0.369158911292245 no 1217 0.381412204094816 1734 441209 YML126C ERG13
SGTC_827 3253-0474 693 µM 0.300743869658252 0.369582431445531 no 1218 0.381804906666593 1909 5402065
SGTC_1558 st069300 45.6 µM 0.30054108500784 0.369665827413231 no 1219 0.381882231340098 1897 24208000
SGTC_1659 st012954 42.1 µM 0.300228636428184 0.36979433509408 no 1220 0.382001381654394 1833 24207262
SGTC_1740 st038286 13.222 µM 0.297914136390084 0.370746723017801 no 1221 0.382884349154234 1806 716786
SGTC_108 0509-0257 621.132 µM 0.297351940588885 0.370978179435675 no 1222 0.383098915486505 1863 536624
SGTC_1016 4226-1401 38 µM 0.296725920599894 0.371235967253287 no 1223 0.383337883017864 1766 2901613
SGTC_3081 9117243 49.47 µM 0.296619335701936 0.371279863445504 no 1224 0.383378573571728 1906 45595589
SGTC_1644 st010134 20.9 µM 0.296518151746252 0.371321536849437 no 1225 0.38341720341657 1900 3818134
SGTC_110 0850-0284 111.64 µM 0.296495735000247 0.371330769565847 no 1226 0.38342576180198 1817 3906265
SGTC_1101 ebselen 5.29 µM 0.296148387566066 0.371473839947059 no 1227 0.383558381233643 1917 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1059 3448-6867 171 µM 0.296148087144813 0.371473963696509 no 1228 0.383558495942272 1952 3934407
SGTC_849 0386-0493 241 µM 0.295985806606704 0.371540812198003 no 1229 0.383620460353113 1788 726119
SGTC_2825 7998094 58.44 µM 0.295543278182907 0.371723123376105 no 1230 0.383789448372977 1778 2987815
SGTC_2211 7117706 200 µM 0.295304554374604 0.371821483853158 no 1231 0.383880618846495 1869 822771
SGTC_462 ag-879 158 µM 0.293555348175957 0.372542457624925 no 1232 0.38454885004252 1896 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2850 9015429 58.44 µM 0.291171860058988 0.373525583519813 no 1233 0.385459941514835 1744 6457570
SGTC_2525 harmine 47.85 µM 0.288832727606357 0.374491214874919 no 1234 0.386354692978644 1854 5280953 A monoamine oxidase inhibitor
SGTC_1856 st057054 55.7 µM 0.288737365590774 0.374530598594682 no 1235 0.386391183166718 1923 1266018
SGTC_3071 9117417 49.47 µM 0.288580949560721 0.374595199949133 no 1236 0.386451037793064 1940 45595590 YGL055W OLE1
SGTC_1005 4092-0690 4.4 µM 0.286863121224264 0.375304911140778 no 1237 0.387108564607855 1761 1529343
SGTC_3274 9138298 49.47 µM 0.286197112047353 0.375580182848844 no 1238 0.387363577766295 1874 17015756
SGTC_617 3770-0098 35 µM 0.285345166084606 0.375932397387262 no 1239 0.387689856480572 1818 5962639
SGTC_810 3825-7150 143 µM 0.284986844947398 0.376080566692577 no 1240 0.387827110209947 1969 22330411 YGL099W LSG1
SGTC_1179 1021-1431 9.29 µM 0.284662951479794 0.376214515539715 no 1241 0.387951188595753 1830 2840958
SGTC_2847 9005661 71.43 µM 0.284024580114872 0.376478562990733 no 1242 0.388195771897492 1855 2991449
SGTC_444 curcumin 90.4 µM 0.28311684282238 0.37685412690729 no 1243 0.388543635436057 1847 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2023 5144124 124 µM 0.283016290940122 0.37689573605339 no 1244 0.388582174484071 1787 2830192
SGTC_2219 9098279 200 µM 0.282544050662655 0.377091171849266 no 1245 0.388763187160482 1904 902349
SGTC_1901 st060216 58.6 µM 0.282458330509946 0.377126650359684 no 1246 0.38879604682678 1757 688792
SGTC_3149 9097855 49.47 µM 0.28173177160633 0.377427405727618 no 1247 0.389074595328048 1933 25236625 YMR079W SEC14
SGTC_2306 7482397 179.52 µM 0.279505600510272 0.378349380130979 no 1248 0.389928420319309 1911 891448
SGTC_555 4296-0685 37 µM 0.279437632213581 0.378377540302279 no 1249 0.38995449723967 1849 2908540 YHR072W ERG7
SGTC_255 tunicamycin 200.472 nM 0.279129464369923 0.378505226449518 no 1250 0.390072736049857 1942 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.277407618910005 0.379218899012839 no 1251 0.390733566035275 2032 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1491 4138-0063 26.5 µM 0.275709877012698 0.379922984381582 no 1252 0.391385454406 1938 23883227
SGTC_2480 5767542 37.17 µM 0.274260736952868 0.380524285035738 no 1253 0.391942127700901 1865 2867358
SGTC_1375 2910-0797 186 µM 0.272933917884398 0.381075083573544 no 1254 0.39245200664289 1847 742508
SGTC_3276 9139060 49.47 µM 0.272081635996398 0.381429016088799 no 1255 0.392779624716793 1854 4870619
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.271295048288711 0.381755755381314 no 1256 0.393082057303271 1889 616764
SGTC_2203 7227154 166.4 µM 0.271105187953755 0.38183463376634 no 1257 0.39315506577139 1848 896304
SGTC_512 prima-1 270 µM 0.270415062389776 0.382121391041617 no 1258 0.393420476748994 1909 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2196 6573537 42.6665 µM 0.270403390069122 0.382126241618344 no 1259 0.393424966158478 1946 2903087
SGTC_2720 fluspirilene 36.88 µM 0.26962801041585 0.382448501590482 no 1260 0.393723224488119 1901 3396 An atypical antipsychotic.
SGTC_1957 st077035 62.4 µM 0.269126490382711 0.382656984581105 no 1261 0.393916172919562 1886 705593
SGTC_556 4058-0063 51.5 µM 0.268410308619033 0.382954761876851 no 1262 0.394191752712255 1836 6615692
SGTC_3152 9099253 49.47 µM 0.268357008166676 0.382976926148543 no 1263 0.39421226432889 1895 25236131
SGTC_281 1672-3440 14.9 µM 0.267723182516444 0.383240523316957 no 1264 0.394456201969629 1914 6833000
SGTC_1322 1348-1070 12 µM 0.266713029218946 0.383660740375508 no 1265 0.394845060673022 1923 6758089
SGTC_1643 st009866 20.2 µM 0.266678018583991 0.383675307023717 no 1266 0.394858539904431 1926 3156273 YOR207C RET1
SGTC_3328 9140624 29.0385 µM 0.265057320821337 0.384349799871992 no 1267 0.395482652384953 1958 4904392
SGTC_3019 9081971 49.47 µM 0.264999804834858 0.38437374299941 no 1268 0.395504806080668 1960 16451803
SGTC_759 3486-0358 89.3 µM 0.262112472225723 0.385576265667093 no 1269 0.396617365704178 1988 875103
SGTC_3299 9121982 43.1275 µM 0.26091109329733 0.38607694357182 no 1270 0.397080534930795 1819 17594604 YPL160W CDC60
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.260190797301493 0.386377219934298 no 1271 0.397358301277818 1816 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_253 dyclonine 31.25 µM 0.260105157236903 0.386412926019684 no 1272 0.397391329955323 1899 3180 An oral anasthetic.
SGTC_2175 5807670 165.306 µM 0.259802463076261 0.386539136614239 no 1273 0.397508075460524 1957 241186
SGTC_1504 k297-0033 30 µM 0.259100478180714 0.386831880643493 no 1274 0.397778857929847 1781 4388117
SGTC_2434 5670830 169.91 µM 0.258730618328714 0.386986146718802 no 1275 0.397921546865594 1839 1549830
SGTC_1663 st014140 55.4 µM 0.258440332120481 0.387107235665413 no 1276 0.398033546499294 1903 4207120
SGTC_2339 9000433 200 µM 0.258153843393144 0.387226751317089 no 1277 0.39814408920907 1763 2988954
SGTC_367 0335-0881 7.1 µM 0.257726440146923 0.387405072712642 no 1278 0.398309019489121 1912 23828853
SGTC_2058 5236698 133 µM 0.255513587768764 0.388328699239669 no 1279 0.399163225155199 1834 766665
SGTC_1290 0986-0249 10.2 µM 0.255463573107485 0.388349582272789 no 1280 0.399182537421379 1952 53329
SGTC_1437 4092-1038 11.6 µM 0.254934145836154 0.388570658178915 no 1281 0.399386981407009 1851 3977136
SGTC_515 4092-1064 102 µM 0.254394307933825 0.388796118480982 no 1282 0.399595473983206 1989 717353
SGTC_22 0964-0034 14.468 µM 0.254143711076589 0.38890079160224 no 1283 0.399692267556566 1850 138402
SGTC_1359 1582-0056 520 nM 0.254094086284225 0.388921520600083 no 1284 0.399711435970453 1901 3661189
SGTC_1753 st043925 64 µM 0.253575746737233 0.389138057462046 no 1285 0.399911667810923 1979 670181
SGTC_3219 9131112 49.47 µM 0.253541974075166 0.389152167220904 no 1286 0.399924714926484 1932 17612988 YMR079W SEC14
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.252314289210206 0.389665176354083 no 1287 0.400399072086108 1872 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1868 st057644 42.7 µM 0.252194877638876 0.389715084798892 no 1288 0.40044521859852 1869 688665
SGTC_3042 9091578 49.47 µM 0.252166568650456 0.389726916897054 no 1289 0.400456158789725 1947 25236497
SGTC_3303 9125618 40.5795 µM 0.251042702630334 0.39019673330996 no 1290 0.400890547072686 1918 22695467
SGTC_818 4072-2707 53.5 µM 0.249833680832999 0.390702327002429 no 1291 0.401357985972895 1826 882871
SGTC_457 grayanotoxin iii 135 µM 0.248054743388794 0.391446586215143 no 1292 0.402046025477883 1911 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3107 9121808 49.47 µM 0.247973148614148 0.391480732814048 no 1293 0.402077591182413 1985 662681
SGTC_320 4092-0846 5.34 µM 0.247908101500901 0.391507954980862 no 1294 0.40210275572633 1939 1359356
SGTC_1174 0739-0097 51.1 µM 0.244275066426339 0.393029217262612 no 1295 0.403508896376297 1878 728447
SGTC_618 k072-0232 33.2 µM 0.24405247709722 0.393122475577994 no 1296 0.403595088774972 1888 5872756 YGL099W LSG1
SGTC_266 formosanin C 406 nM 0.243512668303561 0.393348664889193 no 1297 0.40380413626999 1958 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1403 3909-7815 62.9 µM 0.242631313274578 0.393718045382906 no 1298 0.404145510720051 1876 6615483
SGTC_167 3672-0051 66.205 µM 0.241411945978737 0.394229246239151 no 1299 0.404617927482414 1848 3237971
SGTC_419 nsc-638432 893 µM 0.241332356056893 0.394262619427063 no 1300 0.404648767671619 1887 368090
SGTC_1730 st033808 45.1 µM 0.241120812797712 0.394351326301916 no 1301 0.40473074115694 1849 1045166
SGTC_610 4215-0184 155 µM 0.241120575716238 0.394351425720858 no 1302 0.404730833028887 1888 5605015
SGTC_2863 9028737 58.44 µM 0.240610347121656 0.394565403492089 no 1303 0.404928564958259 2021 6460917
SGTC_2556 citropten 84.59 µM 0.240378675149839 0.394662571728956 no 1304 0.405018354195565 1778 2775 A potential DNA crosslinker.
SGTC_418 lividomycin a 100 µM 0.240183670009843 0.394744366183441 no 1305 0.4050939363242 1980 72394 An antibiotic.
SGTC_3095 9117207 49.47 µM 0.239484063459651 0.395037852690312 no 1306 0.405365126250815 2004 17015229
SGTC_1991 st073000 8.92 µM 0.239337687585261 0.395099265235776 no 1307 0.405421871984594 1961 4301969 YIL048W NEO1
SGTC_536 3852-0578 10.6 µM 0.236688080918832 0.396211366702891 no 1308 0.406449391156016 2005 2869208
SGTC_2695 st077686 51.995 µM 0.236386428058184 0.396338031169347 no 1309 0.406566413327302 1841 2876092
SGTC_2689 tacrolimus 100 µM 0.234481785760637 0.397138045337689 no 1310 0.407305485969649 1864 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1153 4055-0057 267 µM 0.234360419370523 0.397189038035557 no 1311 0.407352591896444 1831 882706
SGTC_1281 0884-0031 11.8 µM 0.234259026796689 0.397231639981754 no 1312 0.40739194641489 1850 1548255
SGTC_1738 st035555 74 µM 0.233037314610852 0.397745060979607 no 1313 0.40786621521937 1909 5331140
SGTC_2475 5812728 15.03 µM 0.231481001239416 0.398399353640808 no 1314 0.408470571742021 1954 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1362 1611-0397 101 µM 0.230888632764937 0.398648467572088 no 1315 0.408700660952994 1869 27816
SGTC_2611 pyromycin 23.93 µM 0.230507276367799 0.398808864595293 no 1316 0.40884880499413 1831 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1527 coumarin 137 µM 0.228431878142014 0.399682067982542 no 1317 0.409655254658858 1960 323 A hepatotoxic, DNA x-linker.
SGTC_2013 4024628 200 µM 0.228076497688961 0.399831641269809 no 1318 0.409793385365851 1936 5230760
SGTC_2849 9019321 12.99 µM 0.227861505223159 0.399922134897233 no 1319 0.409876954940722 1906 16489627
SGTC_3112 9123419 49.47 µM 0.227277348401908 0.400168042595154 no 1320 0.410104042804484 2020 17015854
SGTC_799 1310-0557 151 µM 0.225780056310171 0.400798525902668 no 1321 0.410686244669749 1917 5354492
SGTC_1605 st000082 49.1 µM 0.225729504047099 0.400819817089807 no 1322 0.410705904678695 1970 1114022
SGTC_113 0099-0221 2.5 µM 0.225028249961573 0.401115195891936 no 1323 0.410978648756379 2001 89219
SGTC_1929 genistein trimethyl ether 50.5 µM 0.224872436403589 0.401180834595326 no 1324 0.411039256355834 2065 136420
SGTC_2443 5493264 126.67 µM 0.224708005983867 0.401250106300512 no 1325 0.411103218003228 1982 5340055
SGTC_2729 fluphenazine 10.66 µM 0.223783460218084 0.401639659251318 no 1326 0.411462900220367 1920 3372 An atypical antipsychotic.
SGTC_2337 9009472 200 µM 0.222881956545106 0.40201959767102 no 1327 0.411813689886561 2007 5742383
SGTC_303 1348-1668 34.2 µM 0.222755303984488 0.402072982777338 no 1328 0.411862978100756 1940 5380509
SGTC_2273 7815444 169.05 µM 0.222245692034522 0.40228780690229 no 1329 0.412061313151168 2047 2824616
SGTC_939 1165-0479 45.3 µM 0.220268988182918 0.403121354301055 no 1330 0.412830835442746 2040 1377347
SGTC_365 0121-0052 13.6 µM 0.219844140537646 0.403300564032715 no 1331 0.412996270652583 1951 3101739
SGTC_2659 sanguinarine 24.21 µM 0.218848733561359 0.40372052724611 no 1332 0.413383941509503 1924 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_958 1222-0007 33 µM 0.218440920462037 0.403892616094808 no 1333 0.413542792668928 1968 7312461
SGTC_340 k038-0059 454 µM 0.216017442654883 0.404915657219951 no 1334 0.414487075634463 1939 23733424
SGTC_683 panaxydol 45 µM 0.215852017323229 0.404985513258817 no 1335 0.414551549985518 2001 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_746 1095-0025 46.6 µM 0.213753535685334 0.40587192509266 no 1336 0.415369630293668 1969 6749286
SGTC_3246 9135460 32.98 µM 0.210495518639392 0.407249087149394 no 1337 0.416640474461961 1989 41446951
SGTC_921 1561-0023 372 µM 0.210293952729384 0.407334326812701 no 1338 0.416719127394716 1852 24050882
SGTC_2588 indole-3-carbinol 100 µM 0.210149767860694 0.407395303454905 no 1339 0.416775391745705 2045 3712 Induces cell cycle arrest.
SGTC_86 0417-1630 471.922 µM 0.20991148006641 0.407496081704581 no 1340 0.416868381023675 2042 3634867
SGTC_1635 st007035 42.4 µM 0.208065451038173 0.408277023465531 no 1341 0.417588931435996 1980 3716403
SGTC_775 4577-0580 57.3 µM 0.207949289909534 0.408326176340947 no 1342 0.41763428125568 1992 2006902
SGTC_1750 st081859 2.357 µM 0.205835948881752 0.40922067483598 no 1343 0.418459529637876 1947 5291695
SGTC_3200 9114385 49.47 µM 0.204506579767843 0.409783589834845 no 1344 0.418978825369139 1890 17018030 YLR208W SEC13
SGTC_789 1309-1135 70.6 µM 0.202962249475133 0.410437762606073 no 1345 0.419582269308412 2008 3092424
SGTC_3045 9092950 49.47 µM 0.202499347610227 0.410633894813267 no 1346 0.419763184188821 2082 44120432
SGTC_120 rhodamine 6G 52.259 µM 0.20197704437617 0.410855222301561 no 1347 0.419967335132312 2065 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.200333515643885 0.411551857172275 no 1348 0.420609876057023 1952 5106787 A p450 inhibitor.
SGTC_2741 miltefosine 3.04 µM 0.199729153747378 0.411808095492937 no 1349 0.420846205876531 1975 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1904 st060225 78 µM 0.199125277731766 0.412064165376316 no 1350 0.42108237419147 1970 66595
SGTC_85 0868-0259 160.055 µM 0.198440551388352 0.412354564637408 no 1351 0.421350196406667 1972 83173
SGTC_837 0091-0265 12.5 µM 0.198206963045003 0.412453642766236 no 1352 0.421441569920909 1928 759367
SGTC_2918 7977171 22.06 µM 0.197863250357401 0.412599441048134 no 1353 0.421576028825227 1950 2236483
SGTC_1501 4491-0275 38.4 µM 0.196284063935306 0.413269465303712 no 1354 0.422193916956942 2081 5104718
SGTC_538 2922-0838 53.3 µM 0.196205781816315 0.413302685779291 no 1355 0.422224551390109 2078 777039
SGTC_467 ro 31-8220 72.8 µM 0.194903878404806 0.413855263571982 no 1356 0.422734098946882 2066 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_686 1319-0111 510 µM 0.194850776690858 0.413877805606894 no 1357 0.422754884996822 2049 4562600
SGTC_2081 5214970 32.255 µM 0.192346423278943 0.414941241510448 no 1358 0.42373542835733 2060 2063512
SGTC_1039 k821-0043 94 µM 0.192182739582494 0.415010769117649 no 1359 0.423799532854262 2052 15992768
SGTC_1142 3253-1408 9.78 µM 0.190704024623575 0.415639000405723 no 1360 0.424378742684685 2093 256655
SGTC_2394 5221648 200 µM 0.190608437726683 0.415679617888469 no 1361 0.424416189524267 2037 788586
SGTC_10 0279-0212 42.575 µM 0.190471365127794 0.415737865350988 no 1362 0.424469889870197 2028 39851 YBR002C RER2
SGTC_263 alizarin 107.927 µM 0.189690615646819 0.416069671347258 no 1363 0.424775787463106 1997 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1555 citronellol 128 µM 0.189458086041772 0.416168504270762 no 1364 0.424866901310773 2090 8842 A terpine precursor.
SGTC_2226 7298446 200 µM 0.188965688784722 0.416377807200785 no 1365 0.425059854325374 2073 3283010
SGTC_2630 antimycin a 100 µM 0.187526388514301 0.416989745234093 no 1366 0.42562396781227 1981 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2085 5307070 144.047 µM 0.187507460326468 0.416997794153292 no 1367 0.425631387466075 1924 2840351
SGTC_2975 9084847 53.72 µM 0.18636333414783 0.417484380606325 no 1368 0.426079921900158 1924 27211724
SGTC_323 4013-0906 34.3 µM 0.185969958981544 0.417651708719514 no 1369 0.426234159802149 2090 2910086
SGTC_2519 cryptotanshinone 88.04 µM 0.18388414715468 0.418539188963914 no 1370 0.427052170740101 2055 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1748 st037455 53.6035 µM 0.183573868797784 0.418671243093896 no 1371 0.42717388219368 1985 580690
SGTC_1617 st002906 78 µM 0.183460164035332 0.418719638012243 no 1372 0.427218486370469 1941 5150859
SGTC_2518 prenyletin 46.28 µM 0.183440006995684 0.418728217361647 no 1373 0.427226393683959 2079 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2586 curcumin 80 µM 0.182819897042859 0.418992170816994 no 1374 0.42746966807006 2051 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1884 5633444 25 µM 0.18212793623484 0.419286751058577 no 1375 0.427741162711032 2003 5724239
SGTC_2046 4110841 106 µM 0.182094147143878 0.419301136846256 no 1376 0.427754420924553 2122 44119630 YMR134W ERG29
SGTC_627 1391-0720 175 µM 0.181574529093895 0.419522379069095 no 1377 0.427958319688413 1999 997839
SGTC_473 2-arachidonoylglycerol 10 µM 0.181009208162621 0.419763109495237 no 1378 0.428180174168744 1923 5282280 An endocannabinoid.
SGTC_2411 st077133 39.94 µM 0.180493180389398 0.41998287564953 no 1379 0.428382703869675 2108 1403142 YNL221C POP1
SGTC_2384 9036245 200 µM 0.180461004654326 0.419996579494095 no 1380 0.428395332772671 2059 6462766
SGTC_155 k072-0202 43.6 µM 0.180403773128576 0.420020954994574 no 1381 0.428417796197855 2104 5857737
SGTC_1275 0867-0008 21.1 µM 0.179572157740589 0.420375183186608 no 1382 0.428744232117494 2009 3422836
SGTC_2061 5245884 80.95 µM 0.178162687934007 0.420975696741718 no 1383 0.429297605793323 1991 573863
SGTC_783 0848-0141 92.7 µM 0.177925626355154 0.421076716436867 no 1384 0.429390692513841 1997 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1237 0330-0133 46.1 µM 0.176485517974695 0.421690505165329 no 1385 0.42995626254635 1981 X1237 YHR072W ERG7
SGTC_2363 9053361 176 µM 0.176198973461657 0.421812656076104 no 1386 0.430068813614992 2101 6469797 YMR079W SEC14
SGTC_3053 9095903 49.47 µM 0.175539080354178 0.42209399015715 no 1387 0.430328032897846 2124 17174018
SGTC_2184 6075246 200 µM 0.174254726468356 0.42264166622517 no 1388 0.43083263893231 2017 2267320
SGTC_599 1935-0052 86.5 µM 0.173790698376994 0.422839574602059 no 1389 0.431014977386409 2037 9557311
SGTC_829 1635-0120 117 µM 0.1737065803836 0.422875453084759 no 1390 0.43104803287653 2093 285054
SGTC_3146 9095609 49.47 µM 0.172735851378296 0.423289540130399 no 1391 0.431429531016438 2025 17173999
SGTC_700 3453-2283 142 µM 0.17203070758784 0.423590388789331 no 1392 0.431706693852497 2065 565664
SGTC_1686 st019653 115.5 µM 0.171878971888066 0.42365513245385 no 1393 0.431766339275963 2101 97252
SGTC_2124 5246320 200 µM 0.171661549884495 0.423747907208481 no 1394 0.431851807882676 2013 579342
SGTC_2068 5226020 147 µM 0.171625608123691 0.423763244094953 no 1395 0.431865936899036 1968 1810509
SGTC_1937 st074714 47.2 µM 0.170905378073654 0.42407060133402 no 1396 0.432149083895852 1891 17250970
SGTC_3005 9076496 71.4286 µM 0.170815515102442 0.424108953485207 no 1397 0.432184414543351 2125 21368410
SGTC_862 0452-0056 10.2 µM 0.170697226967673 0.424159438160078 no 1398 0.432230921693399 2083 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2431 5490079 200 µM 0.170568824266419 0.424214241080631 no 1399 0.432281406633715 1987 5722345
SGTC_1444 4112-3581 28 µM 0.170228075734953 0.424359681374173 no 1400 0.432415386348605 2007 2877249
SGTC_3127 9126946 49.47 µM 0.169639073941338 0.424611106866091 no 1401 0.432646995665126 1938 27243249
SGTC_3117 9124945 49.47 µM 0.169625994286234 0.424616690489181 no 1402 0.43265213915517 1908 17592065
SGTC_1067 clotrimazole 1.36 µM 0.168932143255602 0.424912912819659 no 1403 0.432925007937804 1994 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3084 9116877 49.47 µM 0.168568920847223 0.425067998455356 no 1404 0.433067864123864 2115 27241325
SGTC_735 3076-0345 636 µM 0.167995299059108 0.425312942251201 no 1405 0.43329348866439 2093 2888990
SGTC_1721 st082152 9.2685 µM 0.166823339067462 0.425813473594542 no 1406 0.43375452704924 2080 5296051
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.166668544144391 0.425879593775603 no 1407 0.433815428714909 2100 5355888
SGTC_3166 9102297 49.47 µM 0.165910274911776 0.426203516248579 no 1408 0.434113780676983 1965 25237072
SGTC_1519 esterone 74 µM 0.164999709128463 0.426592563552254 no 1409 0.434472105500117 1895 698 A steroid.
SGTC_3326 9140064 16.379 µM 0.164650978015901 0.426741580950187 no 1410 0.434609352049513 2046 1868434
SGTC_2106 5357045 167.29 µM 0.164240322154295 0.426917073014765 no 1411 0.434770979794092 2075 668842
SGTC_2064 5220758 200 µM 0.164213145857146 0.426928687202402 no 1412 0.434781676345826 2022 788518
SGTC_1027 k015-0025 8.67 µM 0.163387528931114 0.427281556807336 no 1413 0.435106660706413 2063 3598955
SGTC_2973 9094665 17.96 µM 0.162675364143304 0.427585983595631 no 1414 0.435387022572635 2102 25237061 YIL048W NEO1
SGTC_1116 jasmonic acid 1.58368 µM 0.16264205818218 0.427600221844383 no 1415 0.435400135111429 2088 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_205 1486-1330 71.903 µM 0.162625038033506 0.427607497968985 no 1416 0.435406835962137 2029 4118834
SGTC_1003 4049-0218 100 µM 0.162020632795812 0.42786589754362 no 1417 0.435644802959337 2065 295161
SGTC_2714 st079313 56.9 µM 0.161852178265551 0.427937921926226 no 1418 0.435711131191379 2016 2939799
SGTC_2656 pseudo-anisatin 100 µM 0.161778077029121 0.427969605395431 no 1419 0.435740308800872 2036 6708809 A neurotoxin.
SGTC_2076 5212012 200 µM 0.161581167820059 0.428053800131545 no 1420 0.435817844159283 2101 604802
SGTC_2018 5133068 143 µM 0.161031141834367 0.42828899841261 no 1421 0.436034436536392 2038 785362
SGTC_16 erodoxin 22.806 µM 0.160972014867443 0.428314283392355 no 1422 0.436057721034596 2080 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1492 4158-0558 28.5 µM 0.15929993183114 0.429029452280735 no 1423 0.436716287231921 2118 3967268
SGTC_2371 9071574 200 µM 0.158472270488797 0.429383538805172 no 1424 0.437042334741708 2128 45596039
SGTC_1064 honokiol 6.76 µM 0.157853319661896 0.429648372844958 no 1425 0.437286191146306 2022 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3293 9120939 62.045 µM 0.157687523215488 0.429719318502732 no 1426 0.437351516258064 2065 934087
SGTC_2158 5657123 3.6195 µM 0.155330250191737 0.430728259409143 no 1427 0.438280484410464 2144 2858827
SGTC_2703 st077852 53.4 µM 0.154448106511802 0.431105944062314 no 1428 0.438628212579655 2043 6281836
SGTC_42 0133-0086 60.653 µM 0.153945247505237 0.431321268421015 no 1429 0.438826453482996 2074 162923 Model of phenazepam hydroxylation.
SGTC_3049 9092223 49.47 µM 0.153658815416356 0.431443927845637 no 1430 0.438939379783953 2045 8623917
SGTC_3162 9099653 49.47 µM 0.152640146524339 0.431880208084485 no 1431 0.439341031802803 2132 25237511
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.152232425957462 0.432054851855428 no 1432 0.439501809894855 2141 4000243
SGTC_166 k072-0058 166.424 µM 0.152232297373425 0.432054906935445 no 1433 0.439501860601492 2169 5846229
SGTC_558 k064-0027 21.3 µM 0.150226931911232 0.432914081488028 no 1434 0.440292789205624 2088 5088526
SGTC_2057 5236571 38.335 µM 0.148939416486277 0.433465869361524 no 1435 0.440800719107327 2124 54684039 YBR257W POP4
SGTC_890 0929-0006 47.2 µM 0.148928651814927 0.433470483303157 no 1436 0.440804966224303 1973 1378169
SGTC_2839 9003951 25.97 µM 0.147982299198206 0.433876143290828 no 1437 0.441178368811839 2214 2990634
SGTC_188 3229-0966 278.469 µM 0.147971880073383 0.433880609902506 no 1438 0.441182480180169 2151 5722370
SGTC_651 3253-0966 34.4 µM 0.14645809792352 0.434529647993024 no 1439 0.441779883092086 2066 781462
SGTC_3335 9143315 29.6265 µM 0.146344713900515 0.434578268818529 no 1440 0.441824634605847 2020 4899691
SGTC_2001 4023502 57.655 µM 0.144059354178295 0.435558476453318 no 1441 0.442726800261596 2072 108941 YCR052W RSC6
SGTC_1060 3448-7350 82 µM 0.141458055549835 0.43667467427251 no 1442 0.443754046800511 2147 570178
SGTC_2673 kobusone 100 µM 0.140091601807132 0.43726121200327 no 1443 0.444293807972811 2135 6710676 An epoxy ketone and protein crosslinker.
SGTC_2844 9010103 25.97 µM 0.138978605644105 0.437739057370866 no 1444 0.444733527593219 2039 2480525
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.138697752560912 0.437859651089197 no 1445 0.444844497065677 2015 61125 An anti-inflammatory.
SGTC_1774 st048371 48.465 µM 0.13860725331293 0.437898511215522 no 1446 0.444880255663875 2079 4242727
SGTC_324 1315-0088 19.6 µM 0.138486109789951 0.437950530846012 no 1447 0.444928123311329 2121 6787421
SGTC_2930 9013230 14.89 µM 0.13821541076051 0.438066774227647 no 1448 0.445035087982996 2126 2995857
SGTC_2137 5261020 140 µM 0.137998793917855 0.438159797525565 no 1449 0.445120685371095 2084 763655
SGTC_1668 st014914 51.6 µM 0.136727066920902 0.438705992969775 no 1450 0.445623267068783 2133 2839556
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.136163615051508 0.438948027925631 no 1451 0.445845969102081 2145 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2275 7947463 200 µM 0.134916316688774 0.439483895325426 no 1452 0.446339019326267 2177 1225414
SGTC_1207 2099-0101 141 µM 0.13400883010688 0.439873841705949 no 1453 0.446697796001916 2156 5837381
SGTC_2088 5278280 127.392 µM 0.133655160324835 0.440025829194418 no 1454 0.446837631905643 2080 791502
SGTC_1951 sophoraflavanone G 9.2 µM 0.133542341317861 0.440074314353114 no 1455 0.446882240296609 1971 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1979 st071809 45.3 µM 0.132052572386717 0.440714642281767 no 1456 0.447471354524897 2122 4976333
SGTC_2282 7944268 200 µM 0.131847001686743 0.440803012262757 no 1457 0.447552654532127 2123 2970414
SGTC_1700 st030840 7.9285 µM 0.13158326742754 0.440916389698462 no 1458 0.447656960546851 2180 5499307
SGTC_496 calpeptin 138 µM 0.129720921986437 0.441717135747358 no 1459 0.448393614540121 2061 73364 A calpain inhibitor.
SGTC_882 0843-0131 351 µM 0.128122215738748 0.442404715969607 no 1460 0.449026127659543 2184 5425421
SGTC_1026 k007-1105 30.6 µM 0.127219450273636 0.442793059015974 no 1461 0.449383355684666 2127 7066794
SGTC_1925 st057770 10.1 µM 0.127105332609819 0.44284215298636 no 1462 0.449428515442831 1938 5989122
SGTC_983 1491-0821 12.2 µM 0.126717747643842 0.44300890045917 no 1463 0.449581899243725 2179 46495113
SGTC_3037 9091026 49.47 µM 0.126514034608699 0.443096546281552 no 1464 0.449662520148973 2188 25236398 YIL048W NEO1
SGTC_146 3448-8650 53.125 µM 0.126490013067792 0.443106881531373 no 1465 0.449672026984332 2072 2891488 YIL048W NEO1
SGTC_1835 st008666 49.2 µM 0.126355271896264 0.443164854535903 no 1466 0.449725353080153 2039 690455
SGTC_1186 1319-0216 26 µM 0.126275590464482 0.443199138408472 no 1467 0.449756888780699 2202 4565136
SGTC_1282 0886-0010 32.4 µM 0.125988125653099 0.443322827054817 no 1468 0.449870662015408 2175 2836211 YNL267W PIK1
SGTC_3154 9100113 49.47 µM 0.125380208110024 0.443584416367496 no 1469 0.450111278050976 2070 25237525
SGTC_1941 st076221 61.8 µM 0.125223571558057 0.443651821680665 no 1470 0.450173278358808 2207 2828568
SGTC_433 pimozide 108 µM 0.125078521447161 0.443714242461542 no 1471 0.450230693574435 2055 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1967 st070177 51.4 µM 0.123058418816634 0.444583716733802 no 1472 0.451030418961872 2138 5729214
SGTC_416 estradiol valerate 100 µM 0.122662965707305 0.444753955427067 no 1473 0.451186995711891 2079 13791 A steroid.
SGTC_1623 st003709 20.3 µM 0.121704740105958 0.445166504373566 no 1474 0.451566429543325 2036 16192618
SGTC_1985 st071382 65.5 µM 0.121318180881503 0.445332948199566 no 1475 0.451719510059453 2211 6123237
SGTC_227 fluconazole 33.516 µM 0.119243032148365 0.446226625209185 no 1476 0.452541407555436 2054 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1372 2752-0194 270 µM 0.116644884495687 0.447345919956769 no 1477 0.453570733896674 2191 823334
SGTC_2271 7849410 118.62 µM 0.115736378925688 0.447737408053256 no 1478 0.453930736880644 2239 972430
SGTC_2870 9038528 12.99 µM 0.113883542576779 0.448535979247555 no 1479 0.454665055901603 2113 6463316
SGTC_1820 st053765 18.6 µM 0.113179329214942 0.448839549599028 no 1480 0.454944191626853 2090 3690829
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.113159595820634 0.448848056648429 no 1481 0.454952013860499 2133 15053
SGTC_2138 5575593 77.673 µM 0.113041941122072 0.448898777976271 no 1482 0.454998652045466 2150 762213
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.112398575156084 0.449176149910439 no 1483 0.455253692515287 2191 94937 An inhibitor of serotonin biosynthesis.
SGTC_3339 9145883 14.936 µM 0.111721162590904 0.449468227069033 no 1484 0.455522249528239 2202 2030670
SGTC_1972 st070201 17.4 µM 0.110801796624836 0.44986467003662 no 1485 0.455886760312964 2212 2829099
SGTC_1935 st074532 41.6 µM 0.110762500972136 0.449881615968433 no 1486 0.455902341107228 2186 2829742
SGTC_1651 st011928 86.1 µM 0.110098811677639 0.450167840381181 no 1487 0.456165505286639 2176 720198
SGTC_2214 7179297 48.276 µM 0.108482739372446 0.450864900143683 no 1488 0.456806385845457 2197 769744
SGTC_2172 5754775 163.918 µM 0.108157745190926 0.451005098116297 no 1489 0.456935281359069 2112 2263357
SGTC_1852 st056254 31.4 µM 0.107682619700452 0.451210071644296 no 1490 0.457123728403161 2120 442583
SGTC_1454 4239-0054 42.6 µM 0.107470024405149 0.451301791435972 no 1491 0.457208052314345 2202 1340767
SGTC_2486 5283202 22.39 µM 0.10718305170998 0.451425603923082 no 1492 0.457321880371925 2083 1377751
SGTC_1088 bifonazole 369 nM 0.105899749866469 0.45197933373231 no 1493 0.457830946265299 2203 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_346 4513-0042 7.16 µM 0.105678803057343 0.452074679166394 no 1494 0.457918599434585 2182 2827372
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.103601782341634 0.452971112715776 no 1495 0.458742686586556 2171 5377381
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.102462848141564 0.453462774068406 no 1496 0.459194650245573 2152 641818 YHR062C RPP1
SGTC_1766 st045414 44.774 µM 0.102374555030272 0.453500891911393 no 1497 0.459229689842438 2225 253960
SGTC_1345 1488-0192 31.4 µM 0.101059334603586 0.454068748522663 no 1498 0.459751679504107 2216 658348
SGTC_1909 st060837 51.5 µM 0.100079380350136 0.454491912479167 no 1499 0.460140652615862 2134 678937
SGTC_404 fumagillin 50 µM 0.0983103357204314 0.45525595200325 no 1500 0.460842935611422 2110 12015870 A methionine aminopeptidase binder.
SGTC_1289 0976-0073 69.1 µM 0.0982972030191704 0.455261624558841 no 1501 0.460848149547472 2171 3391136
SGTC_2513 baicalein 25.65 µM 0.0968349154232952 0.455893303702267 no 1502 0.461428747860233 2132 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3136 9095672 49.47 µM 0.0966074907644045 0.455991556689323 no 1503 0.461519053777109 2249 17217380
SGTC_2877 9040724 71.43 µM 0.0949408380734611 0.456711672954889 no 1504 0.462180909455775 2243 6463895
SGTC_731 3966-0296 387 µM 0.0939252428666022 0.457150554481857 no 1505 0.462584270783437 2221 660956
SGTC_2635 hydroquinidine 100 µM 0.0933846792643853 0.457384176162696 no 1506 0.462798980751557 2186 442912 An experimental heart treatment.
SGTC_3306 9127676 59.7925 µM 0.0931942572368086 0.457466476584575 no 1507 0.462874618298273 2116 41905287
SGTC_2964 9083345 53.42 µM 0.0929544815330118 0.457570110264873 no 1508 0.462969861531015 2144 17741579
SGTC_1242 0402-0103 60.1 µM 0.092684900076496 0.457686629762253 no 1509 0.46307694668092 2223 432868
SGTC_2743 auranofin 4.32 µM 0.0919423187581778 0.458007609791918 no 1510 0.463371934164552 2207 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1720 st037298 9.481 µM 0.0912676224834955 0.45829927033204 no 1511 0.463639972051263 2167 597396
SGTC_1199 1638-0010 4.46 µM 0.0905417887486751 0.458613061854757 no 1512 0.463928343841372 2149 3111136
SGTC_423 5-fluorouracil 457 µM 0.0897202125326218 0.458968275755441 no 1513 0.464254776720333 2179 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_348 k064-0012 10.7 µM 0.0895255980103768 0.459052423439123 no 1514 0.46433210549444 2233 5066323
SGTC_2950 9072895 21.46 µM 0.0892190107341522 0.459184989770086 no 1515 0.464453928622707 2147 17332245
SGTC_2408 sulbentine 18.36 µM 0.0892039597149299 0.459191497849249 no 1516 0.46445990926419 2115 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2041 5107442 45.335 µM 0.0881874437232854 0.459631065833317 no 1517 0.464863848445508 2240 793005
SGTC_648 0375-0473 33.3 µM 0.0873337290350288 0.460000272445281 no 1518 0.465203122270842 2179 1713139
SGTC_2267 7931562 200 µM 0.0868816749334983 0.46019578659945 no 1519 0.465382782858869 2106 934880
SGTC_1939 st074455 53.6 µM 0.0859194166040428 0.460611996924022 no 1520 0.465765238184114 2262 1644229
SGTC_477 mead ethanolamide 10 µM 0.0845336320456033 0.461211472841938 no 1521 0.4663160820112 2261 16061185
SGTC_1474 0330-0125 5.35 µM 0.0818061199473043 0.462391622291744 no 1522 0.467400444687421 2265 X1474
SGTC_152 4469-0003 551.229 µM 0.0814148036058299 0.462560965817677 no 1523 0.467556038308781 2277 697280
SGTC_2566 crystal violet carbinol 226 nM 0.0809136734510656 0.462777841563927 no 1524 0.467755302890274 2039 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0807034239033254 0.46286883525133 no 1525 0.467838906910017 2270 5024745
SGTC_1821 st053465 65.6 µM 0.080255178037994 0.463062837603262 no 1526 0.468017152958019 2187 675086
SGTC_3009 9080819 71.4286 µM 0.0801636934592653 0.46310243352454 no 1527 0.468053532810177 2178 17027216
SGTC_24 0417-1663 219 µM 0.0800212580347697 0.463164082476635 no 1528 0.468110174359291 2172 4329390
SGTC_3148 9097893 49.47 µM 0.0789862155116082 0.463612096436866 no 1529 0.468521793617038 2187 17174100
SGTC_356 1634-0012 32.5 µM 0.0773045244571147 0.464340107748678 no 1530 0.469190645842107 2281 735457
SGTC_2524 avocatin b 10.57 µM 0.0763886653437212 0.464736637486773 no 1531 0.469554943501475 2245 6710748
SGTC_130 0136-0219 337.655 µM 0.0761729566123365 0.464830035702672 no 1532 0.469640748830609 2296 234244
SGTC_2035 5154463 94.595 µM 0.0749291630774049 0.465368614812259 no 1533 0.470135536496232 2259 2769623
SGTC_3236 9132701 49.47 µM 0.0741354783049336 0.465712324074273 no 1534 0.470451292658616 2181 24282524
SGTC_184 1494-0393 24.714 µM 0.0738920529921478 0.465817745792024 no 1535 0.470548139678349 2231 3090647
SGTC_3114 9122766 49.47 µM 0.0722128512519196 0.466545033109468 no 1536 0.471216259027788 2151 17176985
SGTC_2403 6032726 181.2 µM 0.0708415336959639 0.467139054181891 no 1537 0.471761937866695 2220 2881040
SGTC_3288 9119690 36.221 µM 0.0701305398654236 0.467447068136816 no 1538 0.472044879620001 2208 17595618 YKL019W RAM2
SGTC_1882 5615643 20 µM 0.0699748952123507 0.467514498509165 no 1539 0.472106820681889 2297 2253075
SGTC_531 3788-1495 174 µM 0.0687920607503592 0.468026971544372 no 1540 0.472577568860669 2241 2896655
SGTC_1054 3429-0080 167 µM 0.0681862811019853 0.468289451273578 no 1541 0.472818673824131 2270 1162877
SGTC_1515 3460-0031 42.1 µM 0.0679442406322008 0.468394329435036 no 1542 0.472915010583884 2247 2876596
SGTC_1355 1499-0035 1.68 µM 0.0664742844085393 0.469031320620717 no 1543 0.473500115242117 2272 1548538
SGTC_233 rapamycin 362 pM 0.0662715468013467 0.46911918124244 no 1544 0.473580817887135 2288 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_944 3370-0224 231 µM 0.0649502065238875 0.469691848592744 no 1545 0.474106822963173 2255 4580514
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.0643473519697606 0.46995314596035 no 1546 0.47434682506556 2259 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1433 4060-0023 7.6 µM 0.0628269444089993 0.470612198766721 no 1547 0.474952154856278 2259 3840627
SGTC_2956 9076196 2.52 µM 0.062069663522478 0.47094048832622 no 1548 0.47525367770129 2314 16423868
SGTC_2098 5376439 882.5 nM 0.0616569177781665 0.47111942645713 no 1549 0.47541802464415 2262 2844116
SGTC_304 1310-0298 97 µM 0.0614756693177645 0.471198005152385 no 1550 0.475490195410128 2268 1550234
SGTC_2304 7443016 91.4 µM 0.0608162370839352 0.471483905706691 no 1551 0.475752779467141 2287 939854
SGTC_2328 6201408 200 µM 0.0605849849720063 0.471584169848658 no 1552 0.475844865906252 2234 2890418
SGTC_144 4161-2749 112.381 µM 0.0605806623349394 0.471586044034639 no 1553 0.475846587227177 2254 797501 YMR168C CEP3
SGTC_727 3032-0951 202 µM 0.0591042011434273 0.472226236760444 no 1554 0.476434556232633 2248 3652836
SGTC_2670 beta-carotene 100 µM 0.0589940416949015 0.472274004731341 no 1555 0.476478426943335 2306 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_619 1652-1634 108 µM 0.0588094811854556 0.472354035809743 no 1556 0.476551928319606 2228 5400454
SGTC_2201 6605497 169.863 µM 0.0587349695145016 0.472386346664342 no 1557 0.476581602880687 2271 670741
SGTC_2168 5727979 200 µM 0.058643722569256 0.472425914763997 no 1558 0.476617942506349 2296 695210
SGTC_809 3998-0021 90 µM 0.0570640910270081 0.473110945075013 no 1559 0.477247070500066 2309 715485
SGTC_2132 5317594 122.667 µM 0.055972844571561 0.473584226624183 no 1560 0.477681720064634 2265 794577
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0558173608043061 0.473651664118984 no 1561 0.477743652291374 2300 1377
SGTC_343 4130-2827 29.8 µM 0.054954953611858 0.47402572698697 no 1562 0.478087175667754 2233 1118244
SGTC_684 1140-0066 328 µM 0.0537242756108659 0.474559564226694 no 1563 0.478577420794085 2240 6813534
SGTC_2934 9036370 36.88 µM 0.0530422369680529 0.474855435212499 no 1564 0.478849127413392 2284 6462800
SGTC_2826 7992541 19.48 µM 0.0530291034976558 0.474861132699069 no 1565 0.47885435954642 2334 2985066
SGTC_407 eburnamonine 100 µM 0.0523801897687976 0.475142647098562 no 1566 0.47911287935965 2295 3195
SGTC_55 0767-0285 6.563 µM 0.0503636655040844 0.476017542452192 no 1567 0.479916295175326 2324 3116166
SGTC_2960 9079389 5.97 µM 0.0497438694519962 0.476286472481342 no 1568 0.480163248472057 2321 16457355
SGTC_1960 st011366 51.8 µM 0.0495227628170915 0.476382413456904 no 1569 0.48025134867423 2318 3972846
SGTC_1257 0669-0121 16 µM 0.0490153767070118 0.476602579897439 no 1570 0.480453520914275 2277 4307855
SGTC_1161 k007-0610 110 µM 0.0482249172637398 0.476945592539905 no 1571 0.480768496090993 2327 5843850
SGTC_3173 9105693 49.47 µM 0.0478613400488961 0.477103369296267 no 1572 0.480913375116173 2293 17096658
SGTC_1036 k216-0215 33.5 µM 0.0476193642584861 0.477208378294611 no 1573 0.481009799544489 2332 622330
SGTC_2679 rapamycin 1 nM 0.0467913730748404 0.477567709329239 no 1574 0.481339752396459 2285 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2823 7987624 58.44 µM 0.0448214230823767 0.47842269962514 no 1575 0.482124824550284 2280 2239440
SGTC_1260 0700-1617 7.75 µM 0.0428563477224943 0.479275673197315 no 1576 0.482908023113668 2277 2853078
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0422683311844023 0.479530930162841 no 1577 0.483142395383879 2280 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_432 NS 1619 61.3 µM 0.0419195210086189 0.479682352032429 no 1578 0.483281427280337 2221 4552 A K+/calcium channel activator.
SGTC_2274 7947094 46.08 µM 0.0419150854275767 0.479684277579969 no 1579 0.48328319526724 2337 2971028
SGTC_2541 muurolladie-3-one 83.07 µM 0.0418510762375959 0.479712064914068 no 1580 0.483308708851768 2307 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1988 st071872 53.4 µM 0.0413379904606529 0.479934806573962 no 1581 0.483513223466979 2343 16414116
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0409190196412353 0.480116695540611 no 1582 0.483680227332108 2317 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1075 aripiprazole 15.2 µM 0.0399098836127574 0.480554811492454 no 1583 0.484082485699405 2326 60795 An atypical antipschotic. YIL048W NEO1
SGTC_910 3454-3003 490 µM 0.0397628932625599 0.480618629259242 no 1584 0.484141079853766 2339 820824
SGTC_1907 st060210 83.7 µM 0.039725517025747 0.480634856716449 no 1585 0.484155979042871 2311 688793
SGTC_3229 9132204 49.47 µM 0.039626515871806 0.48067783971633 no 1586 0.48419544371437 2308 17682924
SGTC_2551 apiole 73.87 µM 0.0392985924455221 0.480820214735225 no 1587 0.484326164408403 2331 10659 A possible DNA adduct former.
SGTC_1283 0922-0125 16.4 µM 0.0389383859482268 0.480976608963862 no 1588 0.484469756100994 2322 3360884
SGTC_3312 9133330 71.43 µM 0.037821353541037 0.481461619898348 no 1589 0.484915059443742 2309 17617324
SGTC_2628 lathosterol 100 µM 0.0355755260486792 0.48243683139131 no 1590 0.485810411674633 2310 6710616
SGTC_3057 9095946 49.47 µM 0.0349601261863533 0.482704076659702 no 1591 0.486055768058207 2348 24540043
SGTC_1630 st005209 31.3 µM 0.0345114974323384 0.48289890434393 no 1592 0.486234637092733 2349 3367314
SGTC_1388 3346-4487 254 µM 0.0343971303487381 0.482948571619431 no 1593 0.486280235884652 2311 3345614
SGTC_2993 9054257 71.4286 µM 0.0341175271166441 0.483069998673253 no 1594 0.486391716001554 2351 6470217 YGL055W OLE1
SGTC_3058 9093861 49.47 µM 0.032651253807588 0.483706802341583 no 1595 0.486976348484452 2323 17217477
SGTC_925 2064-1272 59.6 µM 0.032620854939427 0.483720005039668 no 1596 0.48698846942144 2293 6815817
SGTC_2356 9061756 188.97 µM 0.0322508216048683 0.48388071766042 no 1597 0.487136013728021 2332 20104043
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0321761812816738 0.483913135711969 no 1598 0.487165775462732 2338 390807
SGTC_1211 1056-0033 32.3 µM 0.0317881947332573 0.484081649122556 no 1599 0.487320480559063 2355 6741922
SGTC_871 0574-0004 149 µM 0.0309157723207815 0.484460576918265 no 1600 0.48766835572132 2245 9551173
SGTC_616 4092-0450 108 µM 0.0308286426521307 0.484498421579495 no 1601 0.487703098869337 2317 787165
SGTC_2677 mitomycin C 100 µM 0.0303129027201363 0.484722435413882 no 1602 0.487908753209757 2347 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1276 0871-0068 94.2 µM 0.0292494120590714 0.485184382252835 no 1603 0.488332836474187 2344 3414906
SGTC_1948 st076329 66.6 µM 0.0288784409188241 0.485345525138426 no 1604 0.488480770052175 2361 24208413
SGTC_2947 9072639 7.68 µM 0.0287061701402922 0.485420357139612 no 1605 0.488549467668368 2348 16488146
SGTC_640 3381-0960 37.1 µM 0.0280044606106639 0.485725175158784 no 1606 0.488829296745309 2337 1745025
SGTC_1247 0448-0043 5.84 µM 0.0274724263577115 0.485956292919226 no 1607 0.489041466061439 2322 3089013 YGL099W LSG1
SGTC_2451 5856223 45.7 µM 0.0272740523702983 0.486042468566775 no 1608 0.489120576188287 2330 2179896
SGTC_399 oxolinic acid 75 µM 0.0269785348667206 0.486170845538498 no 1609 0.489238427247142 2337 4628 A DNA gyrase inhibitor.
SGTC_2598 perillyl alcohol 100 µM 0.0263783873509381 0.486431562480888 no 1610 0.489477766273305 2332 10819 An apoptosis inducer.
SGTC_3132 9126706 49.47 µM 0.026164597167709 0.486524438924871 no 1611 0.489563026788257 2319 850858
SGTC_2809 7964133 12.99 µM 0.0261372609272426 0.486536314606244 no 1612 0.489573928641997 2324 1253665
SGTC_2287 7945887 168.79 µM 0.0260260682865937 0.486584620141668 no 1613 0.489618273002336 2343 1245853
SGTC_2192 5915882 198.485 µM 0.0255830747361719 0.486777072241345 no 1614 0.48979494302815 2350 2876149
SGTC_1256 0570-0116 285 µM 0.0251863151386117 0.486949441288674 no 1615 0.489953176216153 2341 410638
SGTC_2715 st079500 56.4 µM 0.0251528821956822 0.486963966076293 no 1616 0.489966509806504 2363 28246688
SGTC_1225 1216-0074 20.6 µM 0.0250856748377608 0.48699316405479 no 1617 0.489993313205614 2341 4241466
SGTC_2995 9067767 71.4286 µM 0.0247502672357292 0.487138881638275 no 1618 0.490127079943922 2322 11673567
SGTC_873 0591-4978 488 µM 0.0232027264615414 0.487811231512309 no 1619 0.490744281896136 2356 3305145
SGTC_325 2810-4341 181 µM 0.0230010220280226 0.487898867305251 no 1620 0.490824728852677 2365 774970
SGTC_2627 acetyl isogambogic acid 100 µM 0.0228851824181354 0.487949197133024 no 1621 0.490870930009361 2333 6857789 A caspase activator and apoptosis inducer.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0224099025721687 0.488155698040086 no 1622 0.491060490613045 2357 551469
SGTC_3258 9138477 49.47 µM 0.0223454041010721 0.488183721760812 no 1623 0.491086215338427 2370 4970355
SGTC_2812 7970281 58.44 µM 0.0223344746253008 0.488188470477247 no 1624 0.491090574480515 2356 2233435
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0222733981061161 0.488215007468888 no 1625 0.491114934426482 2350 17037758
SGTC_2671 danthron 100 µM 0.0194080910070018 0.489460004559175 no 1626 0.492257777967432 2352 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_675 1309-0189 238 µM 0.01919688622029 0.489551778810876 no 1627 0.492342020791205 2348 4246530
SGTC_1210 3013-0140 750 nM 0.0186249637847634 0.489800297502055 no 1628 0.492570144034022 2378 905973
SGTC_1616 st002734 56.1 µM 0.0171836108584262 0.490426629050579 no 1629 0.493145068450281 2345 4026101
SGTC_854 0422-0053 192 µM 0.0165752425847229 0.490690999127 no 1630 0.493387737700451 2366 3596728
SGTC_3212 9128307 49.47 µM 0.0164283794006135 0.490754820020289 no 1631 0.493446319657212 2333 27243542
SGTC_97 0535-0701 19.132 µM 0.0159370362442239 0.490968339907283 no 1632 0.493642311549648 2371 2832013 YGL099W LSG1
SGTC_603 3794-0023 45.9 µM 0.014530867598189 0.491579423811999 no 1633 0.494203226539249 2379 3802260
SGTC_655 k060-0012 42 µM 0.0143503664635767 0.491657866318534 no 1634 0.494275228565675 2376 5994525
SGTC_696 1560-0013 611 µM 0.0131860480235254 0.492163865532617 no 1635 0.494739680369382 2368 1650269
SGTC_2376 9072922 81.32 µM 0.0129117105182374 0.492283091278465 no 1636 0.494849115881632 2353 17087968
SGTC_3319 9138450 16.7555 µM 0.01276987009043 0.492344734709738 no 1637 0.49490569736037 2366 2029690
SGTC_3225 9130819 49.47 µM 0.0122596200398186 0.492566489376916 no 1638 0.495109241736862 2384 4547121
SGTC_641 4092-0595 30 µM 0.0120658777520602 0.492650690378813 no 1639 0.495186528010044 2366 786260
SGTC_2310 7668677 200 µM 0.0119615127699572 0.492696047861151 no 1640 0.495228160609478 2374 2197143
SGTC_156 3474-0145 5.642 µM 0.0117079183147038 0.492806261524216 no 1641 0.495329323074802 2386 2265471
SGTC_3248 9135562 49.47 µM 0.01045855849737 0.493349248610372 no 1642 0.495827714885249 2377 17650701
SGTC_2799 7812892 81.82 µM 0.00949286888384473 0.493768957645811 no 1643 0.496212950118068 2378 20205235
SGTC_3198 9112019 49.47 µM 0.00828646998845584 0.494293293639472 no 1644 0.496694214598652 2386 45595555
SGTC_2352 9027995 87.8 µM 0.00817976758061069 0.494339670092383 no 1645 0.496736781257843 2357 2997347
SGTC_275 trichlorophene 5.69 µM 0.00813071748142176 0.494360988939857 no 1646 0.496756348765557 2355 62616
SGTC_295 k015-0027 31 µM 0.0078724020061407 0.49447326192755 no 1647 0.496859398431114 2375 3887424
SGTC_2517 totarol 10 µM 0.00687907989345299 0.494904998641893 no 1648 0.497255665824704 2380 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_66 0109-0187 42.4 µM 0.0062297918238711 0.495187207936738 no 1649 0.497514688719318 2391 759417
SGTC_1187 1391-0724 117 µM 0.00621295100804131 0.495194527732351 no 1650 0.497521407102768 2387 6997986
SGTC_3351 9150312 21.596 µM 0.00477557121529209 0.495819285019367 no 1651 0.498094829970732 2397 4904905
SGTC_2813 7971799 71.43 µM 0.00453546517216333 0.49592364817872 no 1652 0.498190617384839 2388 2234054
SGTC_1156 4092-0367 4.88 µM 0.00445273968552519 0.495959605244332 no 1653 0.498223619745841 2388 1357585
SGTC_452 diindolylmethane 8 µM 0.00428364765704919 0.496033102081052 no 1654 0.498291077061615 2392 3071 Inhibits expression of several cancer promoting factors.
SGTC_2438 5259590 200 µM 0.00412989410584269 0.496099932076082 no 1655 0.498352415311141 2394 1201127
SGTC_2731 amoxapine 43.43 µM 0.0037536692407694 0.496263461152641 no 1656 0.498502506149838 2399 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1563 conessine 56.1 µM 0.00328744094760849 0.496466111790393 no 1657 0.498688503173959 2401 441082 An anti-amoebic, histamine inhibitor.
SGTC_318 1488-0629 67.2 µM 0.00296572901195442 0.496605947530229 no 1658 0.498816847039332 2391 3662576
SGTC_744 1594-0068 283 µM 0.00292019366095881 0.496625740020826 no 1659 0.498835012937427 2396 668392
SGTC_1759 st043059 70 µM 0.00254933556312772 0.496786938279772 no 1660 0.498982963358577 2399 669426
SGTC_1206 3978-0017 132 µM 0.0025032170431035 0.496806984326973 no 1661 0.499001361927412 2390 3873677
SGTC_2084 5306078 60.6385 µM 0.00191124230797492 0.497064294962159 no 1662 0.499237525099458 2397 679340
SGTC_716 1683-5115 658 µM 0.00183464879459291 0.497097587564997 no 1663 0.499268081436748 2401 723597
SGTC_2948 9070189 9.45 µM 0.00101056493915156 0.497455790101746 no 1664 0.499596842987301 2401 6473636 YDL196W YDL196W
SGTC_573 3702-0553 84.7 µM 0.00070346601535948 0.497589276588425 no 1665 0.499719357686794 2403 1222756
SGTC_3056 9094900 49.47 µM 0.000582619534724159 0.497641804923298 no 1666 0.49976756844736 2405 25236784
SGTC_164 4100-3994 89.624 µM 0 0.497895052690432 no 1667 0.5 2405 4615967
SGTC_942 3253-1115 227 µM 0 0.497895052690432 no 1668 0.5 2405 46497897
SGTC_1333 1482-0047 286 µM 0 0.497895052690432 no 1669 0.5 2405 3811116
SGTC_1167 k781-0610 148 µM -0.00016473321690783 0.497966657587054 no 1670 0.499934280955086 2405 4525169
SGTC_2753 fluvastatin 17.09 µM -0.000894107355928555 0.498283696768643 no 1671 0.499643302820028 2408 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2370 9071495 200 µM -0.000974298319591676 0.498318553678168 no 1672 0.499611311268085 2408 21791103
SGTC_1327 1436-0082 2.18 µM -0.00117037109776892 0.498403781427895 no 1673 0.499533089591933 2409 15992205
SGTC_2622 2-methoxyxanthone 59.94 µM -0.00130961167695468 0.49846430573965 no 1674 0.499477540680499 2412 71034 A hepatoprotective.
SGTC_201 4262-0159 12.803 µM -0.00228550846940275 0.498888503981846 no 1675 0.499088214833132 2410 1341029
SGTC_3296 9122258 64.045 µM -0.00292277893196869 0.499165510426833 no 1676 0.498833981567917 2415 4730474
SGTC_2087 5276107 200 µM -0.00326262891934179 0.499313235376599 no 1677 0.498698401688012 2414 144405
SGTC_1510 1123-0200 71.5 µM -0.00456651679430864 0.499880006053431 no 1678 0.498178229708175 2417 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2624 nerol 100 µM -0.0051186221435026 0.499880006053431 no 1679 0.497957974126508 2417 637566 A natural product oil.
SGTC_1977 st070720 65.3 µM -0.00529684513781659 0.4998025364941 no 1680 0.497886874402966 2435 682188
SGTC_2974 9094440 9.66 µM -0.00676178919169009 0.499165758546488 no 1681 0.497302456956373 2467 25236134
SGTC_2129 girgensonine 121.053 µM -0.00713765199219604 0.499002379791458 no 1682 0.49715251301559 2424 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_376 3970-0862 59.1 µM -0.00716231791302872 0.498991658099008 no 1683 0.497142672988411 2424 3135186
SGTC_2228 7354201 200 µM -0.00728124932233631 0.498939961438405 no 1684 0.497095227458055 2423 753451
SGTC_414 piperonyl butoxide 100 µM -0.00728567769075614 0.498938036532106 no 1685 0.497093460841518 2420 5794 A potent inhibitor of cytochrome P450.
SGTC_3087 9117406 49.47 µM -0.00781053574040173 0.498709893423907 no 1686 0.496884078741453 2443 42546093
SGTC_2323 6148992 148.28 µM -0.0078969695412052 0.498672322778299 no 1687 0.496849597707303 2434 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2007 4011539 71.82 µM -0.00824998142973692 0.498518877325689 no 1688 0.496708770929905 2423 45595301
SGTC_1048 3161-0300 24.5 µM -0.00951468543995539 0.497969144033502 no 1689 0.496204246964474 2422 2165101
SGTC_2252 omeprazole 400 µM -0.0100072471538259 0.497755041505587 no 1690 0.496007752633956 2468 4594 A proton pump inhibitor.
SGTC_1418 3966-3099 2.4 µM -0.0105145155631722 0.497534547073116 no 1691 0.49580539247322 2422 740335
SGTC_3102 9121669 49.47 µM -0.0109729439093056 0.497335282603959 no 1692 0.495622516579793 2430 41905072
SGTC_1940 st075990 51.1 µM -0.0113486394600783 0.497171979987723 no 1693 0.495472645075445 2535 1084979
SGTC_45 0kpi-0036 14.9 µM -0.0130274512940837 0.496442261353452 no 1694 0.494802945875898 2419 2795021
SGTC_470 aa-861 153 µM -0.0135117907553827 0.496231738655576 no 1695 0.494609739399529 2435 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1917 st066507 28.5 µM -0.0139582050486986 0.49603770141633 no 1696 0.494431662662724 2407 3156428
SGTC_802 4112-3352 742 µM -0.0148827004690095 0.49563586574975 no 1697 0.494062880710653 2514 704594
SGTC_426 0988-0037 14.6 µM -0.014910102576271 0.495623955378763 no 1698 0.494051950064332 2427 5383008
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0152403671221703 0.495480405660637 no 1699 0.493920208544672 2425 16725076
SGTC_2881 9058953 51.95 µM -0.0155755361238807 0.495334724815743 no 1700 0.493786511330569 2434 17122249
SGTC_888 0916-0002 6.97 µM -0.0166601857570287 0.494863287386914 no 1701 0.493353854956254 2513 2802138 YIL048W NEO1
SGTC_3253 9135987 49.47 µM -0.0171640481525263 0.494644288567931 no 1702 0.493152871689953 2438 4182430
SGTC_671 0560-0003 407 µM -0.017372808418252 0.494553553447249 no 1703 0.493069600810195 2455 3238678
SGTC_1098 clofazimine 15.1 µM -0.0174161923197248 0.494534697195212 no 1704 0.493052295755791 2492 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1324 1418-0026 34.4 µM -0.0182817503661492 0.494158496185446 no 1705 0.492707043066385 2479 1372513
SGTC_2735 sertaconazole 140 nM -0.0184181356049286 0.49409921898032 no 1706 0.492652642387936 2438 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2840 9008771 71.43 µM -0.0189942238947673 0.493848834804898 no 1707 0.492422856622021 2460 2992978
SGTC_2766 oltipraz 83.91 µM -0.0195633032184177 0.493601499302244 no 1708 0.492195869008222 2442 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_174 3553-0389 74.3 µM -0.0196959480700158 0.493543849023096 no 1709 0.492142961562869 2455 738071
SGTC_395 anisomycin 6.25 µM -0.0207900659347912 0.493068327337849 no 1710 0.49170656113173 2464 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0207911688410545 0.493067848001437 no 1711 0.491706121230874 2456 6708760
SGTC_941 3237-0776 460 µM -0.0209398162444644 0.49300324413247 no 1712 0.491646832404493 2449 760008
SGTC_2781 5567276 71.43 µM -0.0218486437884977 0.492608261296411 no 1713 0.491284345651014 2475 2853274
SGTC_445 e6 berbamine 66 µM -0.0218758965635424 0.492596417158885 no 1714 0.491273475964733 2470 6610268 A calcium/calmodulin antagonist.
SGTC_2407 paclitaxel 400 µM -0.0223073709042406 0.492408897996823 no 1715 0.491101384607536 2619 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2369 9071472 200 µM -0.0231323157064795 0.492050380899848 no 1716 0.490772364185948 2482 17296037
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0238425888860448 0.491741704680066 no 1717 0.490489084337854 2420 368090
SGTC_2308 7584454 197.62 µM -0.0242150869174484 0.491579823460654 no 1718 0.490340522019642 2452 893577
SGTC_3103 9120822 49.47 µM -0.0244293840058583 0.491486694269038 no 1719 0.490255055134282 2442 17141819
SGTC_1384 3089-0840 101 µM -0.0244637098407805 0.491471776996623 no 1720 0.490241365198816 2430 1069836
SGTC_2958 9077254 16.72 µM -0.0246352467532927 0.49139723090883 no 1721 0.490172952490335 2490 16457351
SGTC_2445 5742597 35.57 µM -0.0255119887250854 0.491016223296231 no 1722 0.489823292990327 2462 1774255
SGTC_3343 9148379 18.9835 µM -0.025942037194533 0.490829339198285 no 1723 0.489651785242661 2461 1955036
SGTC_270 tamoxifen 5.46 µM -0.0268729621810731 0.49042479854805 no 1724 0.489280529390375 2442 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2504 purpurogallin 52.29 µM -0.0269476945836562 0.490392323426272 no 1725 0.48925072626843 2492 5281571 An antioxidant.
SGTC_1387 3342-1166 1.8 µM -0.027436194642588 0.490180046283004 no 1726 0.489055914978109 2504 3418228
SGTC_1800 st050079 29.0735 µM -0.0303146715173855 0.488929265913311 no 1727 0.487908047885894 2452 3645560
SGTC_225 nsc-122657 1.016 µM -0.0308128360566297 0.4887128099078 no 1728 0.487709401794249 2533 275685
SGTC_1573 oleylamine 1.06 µM -0.0309910173902426 0.488635389665652 no 1729 0.487638351658807 2452 5356789 An amine of the fatty acid oleic acid.
SGTC_1631 benzylvanillin 81.9 µM -0.0310891519899851 0.488592750115426 no 1730 0.487599220473548 2519 75506
SGTC_2899 9053889 58.44 µM -0.0311554982377131 0.488563922699579 no 1731 0.487572764965682 2470 6470052
SGTC_1103 duloxetine 36.1 µM -0.0312279715810683 0.488532433131622 no 1732 0.487543866346327 2487 60835 A selective serotonin reuptake inhibitor.
SGTC_2048 5246248 200 µM -0.0314256100744114 0.488446559842098 no 1733 0.487465058674371 2481 677046
SGTC_2917 7979103 53.79 µM -0.0318443095362803 0.488264638047113 no 1734 0.487298105319385 2474 2980565
SGTC_2455 5377712 9.75 µM -0.0321640623877764 0.488125709459075 no 1735 0.487170607700771 2512 2243908
SGTC_2030 5175110 200 µM -0.0325030576014895 0.487978421880835 no 1736 0.487035438853035 2501 2831986
SGTC_223 busulfan 5 mM -0.0326323352376064 0.487922253406629 no 1737 0.486983891882136 2517 2478 A DNA alkylator.
SGTC_2353 9059630 146.67 µM -0.0335375386952148 0.487528967894157 no 1738 0.486622965554248 2495 4779114
SGTC_2297 7971671 152.32 µM -0.0335839383195614 0.487508808882325 no 1739 0.486604465203924 2494 909016
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0346289428418597 0.487054799565738 no 1740 0.486187811142474 2471 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3325 9138760 55.175 µM -0.0350173119922493 0.486886074193669 no 1741 0.486032968182594 2489 43844959
SGTC_1691 st019933 84.6 µM -0.0363299533637989 0.486315820127347 no 1742 0.485509633184165 2465 6176082
SGTC_211 3455-0679 143.504 µM -0.0369570104960116 0.486043415937028 no 1743 0.48525964147987 2500 748649
SGTC_1263 0774-1208 64.8 µM -0.0370796320430013 0.485990147826907 no 1744 0.485210756067008 2481 906585
SGTC_1614 st002383 48.6 µM -0.0374053999735841 0.485848631974087 no 1745 0.485080883564617 2460 1947235
SGTC_1157 4092-0394 27.6 µM -0.0379470114580474 0.485613356134813 no 1746 0.484864965148663 2573 3659885
SGTC_2922 7999257 32.47 µM -0.0379515516112246 0.485611383914914 no 1747 0.484863155193372 2474 2988377
SGTC_1980 st071811 45.7 µM -0.0384888692383441 0.485377978316111 no 1748 0.484648952985264 2591 4974850
SGTC_2534 helenine 20.12 µM -0.038564879180359 0.485344960732449 no 1749 0.48461865190227 2481 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1347 1493-0251 600 nM -0.0392757578057897 0.485036170568357 no 1750 0.48433526708403 2491 3986378
SGTC_2596 sinensetin 100 µM -0.0397850966101674 0.484814930412165 no 1751 0.484132229003302 2498 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1768 st044301 37.178 µM -0.0406486976695637 0.484439821010597 no 1752 0.483787980544122 2500 3931349
SGTC_1306 1185-0270 9.02 µM -0.040895295848716 0.484332712381818 no 1753 0.483689683840444 2495 1548076
SGTC_1405 3909-7894 12 µM -0.0410261947446556 0.484275857590119 no 1754 0.483637506525895 2512 7104060
SGTC_832 4083-0019 164 µM -0.0416006254487647 0.48402636242809 no 1755 0.483408537319487 2540 1990758
SGTC_3151 9099821 49.47 µM -0.0416279262547853 0.484014504896819 no 1756 0.483397655300215 2533 17174189
SGTC_62 0180-0423 3.232 µM -0.0416284277588397 0.484014287079206 no 1757 0.483397455402321 2505 30102 YGL099W LSG1
SGTC_2662 daunorubicin 22.37 µM -0.0422307298006949 0.483752693467671 no 1758 0.483157382783244 2437 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2832 7992762 51.95 µM -0.0423743625217805 0.483690311506186 no 1759 0.483100132865446 2498 2985177
SGTC_384 k007-0144 5.16 µM -0.0429741989794882 0.48342979738216 no 1760 0.482861050539585 2525 6824886
SGTC_1692 fluoroquinolonic acid 71 µM -0.0431654264757139 0.483346747120335 no 1761 0.482784832531612 2576 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_79 0052-0007 94.094 µM -0.0434856164636537 0.483207689959884 no 1762 0.48265721503988 2481 2801472
SGTC_2966 9084041 48.03 µM -0.0454117643389423 0.482371215765214 no 1763 0.481889552037906 2472 17741380
SGTC_3054 9094397 49.47 µM -0.0464444175904281 0.481922793961671 no 1764 0.481478017285683 2502 2598354
SGTC_2120 5538279 151.968 µM -0.0472804175263975 0.481559784086638 no 1765 0.481144867588139 2501 2058197
SGTC_301 4119-0100 24.5 µM -0.0479032406451271 0.481289350276412 no 1766 0.480896678348194 2497 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2188 6126565 140.678 µM -0.0484762874177342 0.481040537278913 no 1767 0.480668331059193 2491 874518
SGTC_2511 berberine 10.47 µM -0.0507241724808424 0.480064593146997 no 1768 0.479772657292894 2506 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3252 9135871 49.47 µM -0.0507855148558931 0.480037962325542 no 1769 0.479748216726303 2579 17682838
SGTC_2204 7233102 200 µM -0.0527207513055638 0.479197856409552 no 1770 0.478977202433048 2487 2172480
SGTC_1164 k060-0068 93.7 µM -0.0530132242288998 0.479070898871421 no 1771 0.478860685559873 2493 5963676
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0532218023755928 0.478980359930069 no 1772 0.47877759222395 2498 2724 A muscle relaxant with antifungal properties.
SGTC_2198 6589944 200 µM -0.0542845979339533 0.478519041942242 no 1773 0.478354210263542 2513 5290268
SGTC_3170 9103054 49.47 µM -0.0551677588522746 0.478135718192305 no 1774 0.478002407255905 2543 16432970
SGTC_626 0214-0009 33 µM -0.0556896450909488 0.477909210191815 no 1775 0.477794524361073 2563 3437874
SGTC_900 1112-0045 141 µM -0.0567076857827567 0.477467382850521 no 1776 0.47738902575039 2505 56211 YIL048W NEO1
SGTC_694 1315-0438 43.2 µM -0.0570177225890911 0.477332833059204 no 1777 0.477265538761206 2545 6793154
SGTC_2420 aureobasidin a 50 nM -0.0570758440666816 0.477307609784101 no 1778 0.477242389345045 2685 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_976 1348-1067 47.6 µM -0.0575298897438134 0.47711056839463 no 1779 0.477061548478831 2516 5310671 YGL099W LSG1
SGTC_3026 9090633 49.47 µM -0.0576329556997184 0.477065841823866 no 1780 0.477020499219686 2515 25236842
SGTC_1779 st039427 55 µM -0.0584993773141701 0.476689860401232 no 1781 0.476675429239155 2499 1124498
SGTC_1314 1222-0010 41.1 µM -0.0590274464326025 0.476460716326853 no 1782 0.476465123564242 2548 3526027
SGTC_1307 1187-1599 12.2 µM -0.0600231589675494 0.476028669829306 no 1783 0.476068594876382 2528 1538471
SGTC_2520 obtusaquinone 4.71 µM -0.0602537112918044 0.475928635594144 no 1784 0.475976783979881 2565 5967872
SGTC_2705 st078069 42.8 µM -0.0610057510426343 0.475602344013199 no 1785 0.47567731445955 2563 1530061
SGTC_81 0411-0046 9.971 µM -0.061095908632887 0.475563227942646 no 1786 0.475641413751919 2506 12925265
SGTC_1849 st056239 19.2 µM -0.0612289678238398 0.475505498871992 no 1787 0.475588430009583 2527 5393181
SGTC_3007 9078383 71.4286 µM -0.062371595701224 0.475009779547322 no 1788 0.475133457126578 2543 6496995
SGTC_3034 9090421 49.47 µM -0.0623884412457258 0.475002471539499 no 1789 0.475126749789363 2501 17173761
SGTC_1670 st016595 4.04 µM -0.0624648437700984 0.474969326367689 no 1790 0.475096328926213 2504 597879
SGTC_2281 7943571 200 µM -0.0625223176565111 0.474944392988416 no 1791 0.475073444892762 2537 1244024
SGTC_1176 0848-0131 83.3 µM -0.0635407951214303 0.474502572435653 no 1792 0.47466793752423 2564 6769040
SGTC_2027 5150920 200 µM -0.0637108484675835 0.474428805494648 no 1793 0.474600233235177 2583 786715
SGTC_884 0851-0618 334 µM -0.0641777438689521 0.474226276826682 no 1794 0.474414349337294 2530 9642473
SGTC_2295 7971645 200 µM -0.0654291805726868 0.473683464878305 no 1795 0.473916145556987 2589 2978226 YKL099C UTP11
SGTC_1122 capsaicin 818.572 nM -0.0659174204298519 0.473471703535243 no 1796 0.473721785624653 2637 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2544 sphondin 68.51 µM -0.0673567539853724 0.472847473879806 no 1797 0.473148848141144 2655 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2246 7293507 91.5585 µM -0.0674699393094441 0.472798388944585 no 1798 0.473103796216841 2638 887656
SGTC_1590 st077108 57.8 µM -0.0675952455630589 0.472744048023112 no 1799 0.473053920117823 2502 5489485
SGTC_943 3253-1379 105 µM -0.0683038036738166 0.472436780828474 no 1800 0.472771898154449 2589 668464
SGTC_3142 9086498 49.47 µM -0.0683051013405901 0.472436218108493 no 1801 0.472771381666551 2534 25236367
SGTC_3108 9121785 49.47 µM -0.0690824787804606 0.472099126226758 no 1802 0.472461983806595 2496 17140271
SGTC_2549 cedrol 20.94 µM -0.0710079182782778 0.471264290145683 no 1803 0.471695726763093 2545 6708665 A sedative which affects the nervous system.
SGTC_2231 micatex 6.853 µM -0.0714098963715896 0.47109001545287 no 1804 0.471535766776728 2552 20737 An antifungal of unknown mechanism.
SGTC_1545 lovastatin 49.4 µM -0.0717841325632708 0.470927773036229 no 1805 0.471386850310202 2570 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2461 5755302 26.15 µM -0.0729461127837862 0.470424051240654 no 1806 0.470924499482292 2568 2788904
SGTC_2096 5468907 200 µM -0.073321295936435 0.470261418323401 no 1807 0.470775222801002 2605 759785
SGTC_606 k015-0008 38.6 µM -0.0735346430539659 0.4701689396647 no 1808 0.470690338757539 2568 1970475
SGTC_46 0329-0187a 2.197 µM -0.0736420913475037 0.470122365123297 no 1809 0.470647588997428 2564 46494817
SGTC_1718 roemerine 11.9335 µM -0.073740539410702 0.470079692180882 no 1810 0.470608420397899 2545 235224 An aporphine alkaloid with mutagenic activity.
SGTC_687 k029-0044 34.9 µM -0.0740137026182631 0.469961289643098 no 1811 0.470499741027036 2546 5829338
SGTC_3131 9127911 49.47 µM -0.0754751988450193 0.469327849770838 no 1812 0.469918314848041 2698 45595681
SGTC_3347 9188721 44.724 µM -0.0759096214245356 0.469139577771907 no 1813 0.469745501079129 2600 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1297 1068-0111 14.1 µM -0.0761060936157843 0.469054432039208 no 1814 0.469667346099873 2521 767057
SGTC_1229 0139-0193 12.2 µM -0.0769747103021768 0.468678014078173 no 1815 0.469321831759128 2552 3090752
SGTC_103 0844-0104 51.839 µM -0.0777058864617787 0.468361178121024 no 1816 0.469031005774044 2652 5375804
SGTC_121 0557-0495 61.343 µM -0.0793224513467999 0.467660753660905 no 1817 0.468388074486146 2556 3104427
SGTC_2929 9013348 24.6 µM -0.0804661819376619 0.467165258960471 no 1818 0.467933245948118 2621 2995952
SGTC_1962 st076595 64.5 µM -0.0820635890104585 0.466473304785259 no 1819 0.467298073594848 2553 279619
SGTC_2801 7907800 81.82 µM -0.0826554198669154 0.466216965042985 no 1820 0.467062766655467 2620 6620925
SGTC_1687 st020778 55.3625 µM -0.0830071017901939 0.466064647657023 no 1821 0.466922946346221 2566 4259299
SGTC_2790 5423970 71.43 µM -0.0833574744978601 0.46591290224997 no 1822 0.466783650608548 2636 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2796 7949634 45.45 µM -0.0839066984245139 0.465675044935732 no 1823 0.466565306885855 2548 2971588
SGTC_2777 climbazole 1.536 µM -0.0857697884635189 0.464868271730188 no 1824 0.465824711632714 2558 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_29 0299-0004 12.984 µM -0.0873672566294968 0.464176635527101 no 1825 0.465189797627179 2559 16871 A napthoquinone isolated from Swertia calycina.
SGTC_764 1951-2361 146 µM -0.0887424777273142 0.463581309531234 no 1826 0.464643286671516 2578 5438930
SGTC_1572 epiandrosterone 68.9 µM -0.0892853154064029 0.463346340320813 no 1827 0.464427582032615 2591 441302 A steroid.
SGTC_2909 7941780 10.49 µM -0.0909552022057709 0.462623604429855 no 1828 0.463764093454298 2571 1243215
SGTC_766 1391-0721 126 µM -0.0922339541755396 0.462070237058277 no 1829 0.463256080740967 2693 1020919 YIL115C NUP159
SGTC_1429 4049-0205 9.46 µM -0.0923270504275292 0.462029953422318 no 1830 0.463219098510248 2554 22774478
SGTC_2532 xanthone 78.9 µM -0.0930014195693601 0.461738159119338 no 1831 0.462951216729401 2634 7020 An insecticide.
SGTC_2976 9009005 19.48 µM -0.0934187137889315 0.461557609448028 no 1832 0.462785462037317 2591 2993148
SGTC_2739 tacrine 100.86 µM -0.0935539012849402 0.461499119901382 no 1833 0.462731765189744 2654 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1736 st036774 51 µM -0.0936020520450079 0.461478287435142 no 1834 0.462712639738548 2768 1272247
SGTC_1112 tnp00069 1.16933 µM -0.0953221558884931 0.460734152845467 no 1835 0.462029472463249 2690 145826
SGTC_3039 9090270 49.47 µM -0.0954233346605639 0.460690386125321 no 1836 0.461989291133292 2589 17173750
SGTC_1809 st050081 57.6 µM -0.0960744332346497 0.460408752996505 no 1837 0.461730728340879 2704 5036894
SGTC_1353 1498-1206 8.11 µM -0.0962939009104401 0.460313826573173 no 1838 0.461643577473332 2570 6756808
SGTC_847 0342-0274 5.54 µM -0.097305795235422 0.45987618093936 no 1839 0.461241776955291 2682 18097
SGTC_391 gliotoxin 8.33 µM -0.0974888314643654 0.459797022704462 no 1840 0.461169101591461 2683 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_315 k915-0449 187 µM -0.0985222192782536 0.459350140318758 no 1841 0.460758814677643 2606 20970215 YNL149C PGA2
SGTC_76 0433-0009 400.328 µM -0.1010777648682 0.458245231617551 no 1842 0.459744364349497 2742 2841569
SGTC_3010 9080089 71.4286 µM -0.102228053682582 0.457748000651992 no 1843 0.45928783039012 2632 17027233
SGTC_230 MPP+ 141.667 µM -0.104879628610486 0.456602067619049 no 1844 0.458235661909832 2627 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1452 4194-0072 190 µM -0.105569071679546 0.456304169236004 no 1845 0.457962132406124 2729 1343545
SGTC_3294 9122953 26.2835 µM -0.106014724281104 0.456111622247137 no 1846 0.457785334868259 2591 16459826
SGTC_1996 st072960 66.8 µM -0.106021499270345 0.456108695150153 no 1847 0.457782647185685 2579 1719405
SGTC_565 1418-0001 44.5 µM -0.108231853614151 0.455153851739073 no 1848 0.456905888915823 2700 2862145
SGTC_836 0330-0104 1.35 µM -0.109115176876593 0.454772340076858 no 1849 0.456555568679372 2612 46494820
SGTC_582 0987-0078 156 µM -0.109164987768023 0.454750827747031 no 1850 0.456535815008294 2606 1625765
SGTC_1239 0337-0584 35.4 µM -0.109583310047896 0.454570167947051 no 1851 0.456369923792449 2714 914301 YML130C ERO1
SGTC_2903 5923464 63.88 µM -0.10971009816082 0.454515414134829 no 1852 0.456319645794886 2600 2876576
SGTC_1923 st058458 19.1 µM -0.113379877670172 0.452930987963724 no 1853 0.454864696062931 2781 3534982
SGTC_3121 9125696 49.47 µM -0.113519186624918 0.452870855964537 no 1854 0.454809476337709 2567 1235365
SGTC_489 paxilline 115 µM -0.114842273833784 0.452299806193833 no 1855 0.454285070515372 2659 105008 A toxic potassium channel blocker.
SGTC_3004 9076122 71.4286 µM -0.115753869988297 0.451906414953789 no 1856 0.453923805541437 2694 44782551
SGTC_3265 9137266 49.47 µM -0.116006094092825 0.451797578200213 no 1857 0.453823856009791 2584 17224265
SGTC_2469 5655019 90.81 µM -0.117437363275681 0.45118004274572 no 1858 0.4532567386468 2779 2788239
SGTC_2694 st077685 81.9 µM -0.117959612743641 0.450954742309956 no 1859 0.453049829380475 2605 2838096
SGTC_3061 glucosamine 200 µM -0.118026790662995 0.450925762641735 no 1860 0.453023215181184 2590 91431 and experimental redox chemotherapeutic
SGTC_2607 solasodine 47.35 µM -0.119504166678654 0.45028850852281 no 1861 0.452437969581013 2648 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1369 1866-0067 208 µM -0.120157521274 0.450006730105481 no 1862 0.452179183509778 2622 3531355
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.120272819289654 0.449957007051644 no 1863 0.452133517427533 2587 6708784 An antioxidant flavonoid
SGTC_331 k048-0133 24.5 µM -0.12036810188556 0.449915916376623 no 1864 0.452095779329975 2612 6813582
SGTC_12 0849-0099 9.267 µM -0.121330951241922 0.449500717233916 no 1865 0.451714452780739 2583 6071388
SGTC_1268 0828-0275 2.46 µM -0.121471511684563 0.449440109483804 no 1866 0.451658788986079 2722 745337
SGTC_450 aminopyrene 156 nM -0.121901755420077 0.449254601576642 no 1867 0.451488412686851 2634 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1728 st035614 33.7865 µM -0.122597769399251 0.448954525191077 no 1868 0.451212810440503 2759 15945546
SGTC_2905 7799065 20.05 µM -0.123411379040484 0.448603786156484 no 1869 0.45089067339191 2688 1296806
SGTC_2639 lactacystin 53 µM -0.125480385181958 0.44771203973362 no 1870 0.450071626327032 2722 3870 A proteasome inhibitor.
SGTC_2875 9039966 71.43 µM -0.125960586500928 0.447505109469362 no 1871 0.449881561716924 2733 6463691
SGTC_3214 9129694 49.47 µM -0.126180454749318 0.447410367733529 no 1872 0.449794541273518 2706 17158655
SGTC_118 0083-0097 135.343 µM -0.127530741148211 0.446828592206937 no 1873 0.449260171950019 2662 5207356
SGTC_3292 9120825 59.784 µM -0.127536658811988 0.446826042812093 no 1874 0.449257830264955 2642 24824900
SGTC_1481 3346-2004 36 µM -0.127613485604421 0.446792945181793 no 1875 0.449227429213165 2639 2770522
SGTC_2658 polymyxin b sulfate 77.05 µM -0.127686289160596 0.446761581137616 no 1876 0.449198620467146 2664 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2258 7960471 200 µM -0.127693805234486 0.446758343203845 no 1877 0.449195646332845 2690 2974708
SGTC_1641 st009299 47.1 µM -0.128465210005154 0.44642604000544 no 1878 0.448890414226239 2628 4046054
SGTC_3348 9149464 3.537 µM -0.129670702966231 0.445906817145614 no 1879 0.448413481237043 2606 1951442
SGTC_3191 9110352 49.47 µM -0.130768614973445 0.445434011602858 no 1880 0.447979175687609 2605 17122424
SGTC_1959 st077091 55.8 µM -0.132615351125717 0.444638907314433 no 1881 0.447248795607809 2612 821356 YKL052C ASK1
SGTC_2387 9077560 195.08 µM -0.132964446536494 0.444488630722412 no 1882 0.447110749167663 2617 5303272
SGTC_2182 6325192 200 µM -0.133045825095871 0.444453600492543 no 1883 0.447078569715301 2631 736248
SGTC_2759 disulfiram 3.38 µM -0.133294505469151 0.444346556182489 no 1884 0.446980236413378 2647 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1228 0124-0032 52.5 µM -0.133519822068968 0.444249572298959 no 1885 0.446891144439321 2709 X1228
SGTC_284 0988-0104 32.6 µM -0.135763653440302 0.443283934483423 no 1886 0.446004062656734 2737 4666532
SGTC_2302 7771753 200 µM -0.137130849719875 0.442695723249882 no 1887 0.445463684127135 2712 2203047
SGTC_506 n9-isopropylolomoucine 153 µM -0.137171645351631 0.442678173608249 no 1888 0.445447561378308 2639 6610355
SGTC_1919 st067113 52.3 µM -0.138171543831508 0.442248068192753 no 1889 0.445052422044843 2775 1268243
SGTC_3322 9139058 2.11 µM -0.139819401494264 0.44153939248579 no 1890 0.444401341849742 2805 4908926 YPR165W RHO1
SGTC_2904 7225135 42.03 µM -0.140166445834415 0.441390166786357 no 1891 0.444264241243873 2742 4446116
SGTC_527 4476-4215 268 µM -0.140373740773004 0.441301035941386 no 1892 0.444182352117185 2673 4418754
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.141077146430105 0.440998613980646 no 1893 0.443904498787372 2657 16486 A toxic proline analog.
SGTC_23 0213-0011 39.996 µM -0.141945454392731 0.440625341450348 no 1894 0.443561545187962 2761 627608
SGTC_2349 9023730 187.07 µM -0.142403736085088 0.440428354292238 no 1895 0.443380555746642 2763 4126287
SGTC_1828 st055811 49 µM -0.144901009104556 0.439355190265165 no 1896 0.442394514847572 2762 5877589
SGTC_1696 st025591 34.7925 µM -0.145281187970699 0.439191853225549 no 1897 0.442244433481154 2671 2787147
SGTC_2592 piperlongumine 83.33 µM -0.145468931989394 0.439111196187959 no 1898 0.442170321741943 2749 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_341 1486-1430 230 µM -0.145621723909018 0.439045556848764 no 1899 0.442110008798114 2652 2054753 YPL210C SRP72
SGTC_566 0958-0068 16.5 µM -0.145808415326547 0.438965356576086 no 1900 0.442036316218918 2793 6815365
SGTC_2393 9031399 185.94 µM -0.146234385155386 0.438782374709085 no 1901 0.441868180945526 2781 1526623 YDL150W RPC53
SGTC_1455 4262-0120 131 µM -0.147685076077314 0.438159306574859 no 1902 0.441295655019752 2855 1529587
SGTC_844 0330-0132 15.3 µM -0.148260760363456 0.437912094001548 no 1903 0.441068490875838 2780 2828079
SGTC_503 tyrphostin 8 294 µM -0.148853473378951 0.437657594202009 no 1904 0.440834627478645 2714 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1567 st069303 68.4 µM -0.148947080770292 0.437617403307453 no 1905 0.440797695228099 2775 5581319
SGTC_529 4076-0302 30.3 µM -0.14903860752834 0.437578106367585 no 1906 0.440761584377172 2693 5816522
SGTC_1221 2958-7315 257 µM -0.149489977201919 0.437384320174224 no 1907 0.440583508769359 2753 4562705
SGTC_561 1550-0330 72.9 µM -0.15173777584717 0.436419499063925 no 1908 0.439696880659067 2694 6812934
SGTC_1620 st003704 16.5 µM -0.1519145309841 0.436343646537347 no 1909 0.439627173624244 2688 2834414
SGTC_2965 9082772 38.63 µM -0.153161920983679 0.435808409522512 no 1910 0.439135292979378 2773 16459634
SGTC_1887 st057648 70.8 µM -0.155265508406122 0.434906057333613 no 1911 0.438306003061051 2837 688672
SGTC_1252 0493-0875 34.8 µM -0.156056238341274 0.43456695421776 no 1912 0.437994346201004 2672 3960963
SGTC_2643 anethole 100 µM -0.160820052836812 0.432525028057577 no 1913 0.436117565466301 2713 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_936 3005-4620 401 µM -0.161049525820058 0.432426713482475 no 1914 0.436027196875154 2871 777207
SGTC_1851 st056236 18.9 µM -0.161620573795051 0.432182073925642 no 1915 0.43580232738733 2704 5393171
SGTC_316 k060-0003 58.6 µM -0.16300419526188 0.431589432177875 no 1916 0.435257565755507 2830 6152314
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.163388380459517 0.431424902726268 no 1917 0.435106325499996 2832 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3308 9128332 17.569 µM -0.164343761576006 0.431015807078101 no 1918 0.434730266622243 2846 17332805 YDL196W YDL196W
SGTC_2887 9044784 58.44 µM -0.164932349667265 0.43076380957319 no 1919 0.434498614861815 2707 6465546
SGTC_2077 5212015 200 µM -0.166000959247896 0.430306368272053 no 1920 0.434078097638072 2660 780900
SGTC_1724 st037281 8.293 µM -0.168374194781493 0.429290789120728 no 1921 0.433144453924136 2703 574124 YDL195W SEC31
SGTC_1350 1495-0454 146 µM -0.16924560956219 0.428918001495903 no 1922 0.432801727983783 2852 1069057
SGTC_2684 capsaicin 100 µM -0.169288996298688 0.428899442484321 no 1923 0.432784665373429 2799 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1762 st045503 25.4615 µM -0.170019786591738 0.428586864948112 no 1924 0.432497287873942 2771 4645554
SGTC_2243 6634756 200 µM -0.170297280509078 0.428468185486814 no 1925 0.43238817493162 2990 885676
SGTC_300 r073-0011 5.04 µM -0.170354568294427 0.428443685273883 no 1926 0.432365649534417 2724 2735780
SGTC_2270 7924575 90.91 µM -0.170540812904727 0.428364036123896 no 1927 0.432292420193224 2929 1262135
SGTC_2869 9037858 32.47 µM -0.173595183847782 0.427058226111473 no 1928 0.431091808642771 2682 27187042
SGTC_133 0724-0033 378.92 µM -0.174933350515056 0.426486381574832 no 1929 0.43056600219529 2682 280309
SGTC_1757 st041620 31.8375 µM -0.175750714473335 0.426137169837735 no 1930 0.430244895483725 2784 5289815
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.176507054430075 0.425814081660862 no 1931 0.429947803528314 2689 6312947
SGTC_1711 st032263 62.8 µM -0.177199679971851 0.425518254251715 no 1932 0.429675773515868 2761 3958979
SGTC_1466 k213-0079 57.5 µM -0.178112237146944 0.425128555836782 no 1933 0.429317415921607 2709 3657981
SGTC_3161 9100388 49.47 µM -0.179258845547595 0.424639011922854 no 1934 0.428867229935678 2743 25236368
SGTC_2165 5727197 32.143 µM -0.179469692905927 0.424549003371208 no 1935 0.428784456254895 3132 1361712
SGTC_333 3486-0131 40.1 µM -0.180399673145449 0.424152051454892 no 1936 0.428419405453813 2865 6744690
SGTC_3119 9125183 49.47 µM -0.180735951136922 0.424008533781996 no 1937 0.428287419267454 2802 22695334
SGTC_1885 st057546 99.9 µM -0.181914188060654 0.423505762127238 no 1938 0.427825034909829 2881 702008
SGTC_1841 st054148 70 µM -0.182106738904881 0.423423609562664 no 1939 0.427749480141198 2810 675442
SGTC_2821 7996764 71.43 µM -0.182560883049321 0.423229860392667 no 1940 0.427571289624651 2916 2987135
SGTC_3130 9127414 49.47 µM -0.183601366771528 0.422786034257904 no 1941 0.427163095410771 2716 1494646
SGTC_2335 9018011 154.17 µM -0.184324648731348 0.42247757061468 no 1942 0.426879389157425 2844 6458208
SGTC_2589 lobaric acid 100 µM -0.184755621100054 0.422293793089029 no 1943 0.42671035887126 2765 73157 A novel microtubule depolymerizer.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.186805594884799 0.421419864650072 no 1944 0.425906530028235 2716 107982 A Capsaicinoid.
SGTC_126 0417-1624 672.48 µM -0.187625950725595 0.421070245271335 no 1945 0.42558494088914 2761 41912 YDL195W SEC31
SGTC_557 1315-0110 16.2 µM -0.188723677235185 0.420602513415777 no 1946 0.425154696648648 2741 6833801
SGTC_2083 5306046 65.942 µM -0.18879863703558 0.420570577767877 no 1947 0.425125320059946 2778 539837
SGTC_3243 9134147 49.47 µM -0.190781595059212 0.419725954763876 no 1948 0.424348354422323 2773 24282180
SGTC_2307 7538926 6.34 µM -0.191296456419318 0.419506714524832 no 1949 0.424146668597854 2802 96582
SGTC_1 0258-0098 57.368 µM -0.19176472711291 0.419307335395887 no 1950 0.423963250908401 2808 6790032 YDR047W HEM12
SGTC_2833 9001315 45.46 µM -0.192284691033554 0.419085970729557 no 1951 0.42375960471597 2781 2989378
SGTC_811 0416-0114 265 µM -0.19238810110993 0.4190419489241 no 1952 0.423719106123102 2824 6612453
SGTC_1108 betulinic acid 729.144 nM -0.194576092791256 0.418110756427756 no 1953 0.4228624102554 2778 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_774 k060-0086 136 µM -0.194818497071046 0.418007619162492 no 1954 0.422767520584661 2724 5911235
SGTC_2704 st078022 71.1 µM -0.195512843200494 0.417712222601661 no 1955 0.422495742135336 2899 54697681
SGTC_3215 9129942 49.47 µM -0.195879546954744 0.417556234078074 no 1956 0.422352223157817 2843 17682944
SGTC_1421 4029-0249 71.4 µM -0.196806381435196 0.417162034905728 no 1957 0.421989528561305 2902 2894095
SGTC_1525 8-methoxypsoralen 92.5 µM -0.197441050579863 0.416892146842938 no 1958 0.421741204050519 3010 4114 Related to psoralen; DNA damaging agent.
SGTC_680 0417-1641 114 µM -0.198025809760806 0.416643517260626 no 1959 0.421512435154939 2740 2835990
SGTC_3242 9133940 49.47 µM -0.199756160436912 0.415907997478088 no 1960 0.420835644564689 2910 17248444
SGTC_2762 leflunomide 42.06 µM -0.199813327572758 0.415883702467003 no 1961 0.42081328881198 2768 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2846 9008642 19.48 µM -0.200769878225448 0.415477233296561 no 1962 0.42043925851172 2899 2992898
SGTC_2024 5144227 134 µM -0.202579461799843 0.414708530659841 no 1963 0.419731872128145 2920 3475211
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.203461682362717 0.414333885696076 no 1964 0.419387096154144 2845 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_786 4544-0069 423 µM -0.20498176810603 0.413688547048319 no 1965 0.418793184759882 2893 748821 YLR208W SEC13
SGTC_73 0327-0325 16.231 µM -0.207969361819453 0.412420871848636 no 1966 0.417626445014741 2940 53298
SGTC_2775 cyproheptadine 69.59 µM -0.210747326476648 0.411242963863162 no 1967 0.41654222134073 2823 2913 A selective serotonin reuptake inhibitor.
SGTC_1168 k815-0004 80.5 µM -0.211094273740629 0.411095907815469 no 1968 0.416406854225265 2768 642433
SGTC_2155 5570423 76 µM -0.212059517688079 0.41068684813793 no 1969 0.416030300812788 2800 797402
SGTC_1803 st050068 52.4 µM -0.21390068291903 0.409906852406466 no 1970 0.415312253833082 2784 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2587 piperic acid 92.2 µM -0.214453672376501 0.409672652053571 no 1971 0.415096645290629 2873 5370536
SGTC_726 3448-4391 34.2 µM -0.215812194542011 0.409097432022656 no 1972 0.414567071216985 2959 1356692
SGTC_1462 k081-0014 26.5 µM -0.215933351392113 0.409046141759503 no 1973 0.41451984982891 2810 3270634
SGTC_1441 4106-0040 13 µM -0.220507853885299 0.407110729339693 no 1974 0.412737828195663 2788 2904180
SGTC_650 1328-0195 38 µM -0.22054630461948 0.407094470872449 no 1975 0.412722857073437 2816 2780821
SGTC_2802 7925815 54.55 µM -0.22145857220782 0.406708775638516 no 1976 0.412367695170462 2801 1262923
SGTC_1020 4335-0961 93.3 µM -0.221490381591162 0.406695328662556 no 1977 0.412355312507889 2761 669075
SGTC_1934 st074720 32.6 µM -0.222429317078934 0.406298456313569 no 1978 0.411989845825696 2788 17250992
SGTC_598 3937-0236 20.2 µM -0.222513643847954 0.406262817500993 no 1979 0.411957026614667 2872 1379313
SGTC_3218 9131285 49.47 µM -0.223641350555452 0.405786292369725 no 1980 0.41151819269836 2941 17156417
SGTC_1400 3771-8998 51.5 µM -0.224716519244889 0.405332097721782 no 1981 0.411099906379126 2805 670767
SGTC_277 nystatin 15.5 µM -0.226649340540397 0.404515916893185 no 1982 0.410348211156844 2763 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1357 1503-1303 39.5 µM -0.227404289327365 0.404197233993169 no 1983 0.41005469262679 2826 292895
SGTC_2222 6885208 172.143 µM -0.227791551698361 0.404033785443718 no 1984 0.409904147410624 2842 609514
SGTC_991 3996-0057 64.7 µM -0.229863080884171 0.403159757819582 no 1985 0.409099082685836 2901 715343
SGTC_3244 9134489 49.47 µM -0.230663694735637 0.402822089044327 no 1986 0.408788040180675 2879 16584271
SGTC_2871 9038510 12.99 µM -0.231020227821035 0.402671740121499 no 1987 0.408649543757761 2961 4945164
SGTC_992 3909-8734 162 µM -0.231798258591628 0.402343696903418 no 1988 0.408347354833656 2866 4288319
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.232788977858056 0.40192607681363 no 1989 0.407962636111048 2842 688801
SGTC_1790 st045711 43.5 µM -0.23296956557973 0.401849965320182 no 1990 0.407892519358915 2979 585119
SGTC_145 3737-0113 38.366 µM -0.23398906772993 0.401420350248004 no 1991 0.407496732896582 2954 6849351
SGTC_1671 st016596 74.5 µM -0.235152221443335 0.400930346373269 no 1992 0.407045293998214 2859 2829167
SGTC_309 k408-0051 1.48 µM -0.236332294409902 0.400433374123442 no 1993 0.406587414631699 2848 3640463
SGTC_892 0929-0076 29 µM -0.236570180467734 0.400333211022447 no 1994 0.406495128056713 2843 5751038
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.236646574586271 0.400301046291243 no 1995 0.406465492484163 2811 4620898
SGTC_2696 st077691 74.316 µM -0.237410058631912 0.399979628634347 no 1996 0.406169343556873 2965 757133
SGTC_2465 5809242 33.21 µM -0.237437956241439 0.399967885355897 no 1997 0.406158523328365 2811 2731748
SGTC_1420 4'-methoxyflavone 42 µM -0.237704161095552 0.399855833076079 no 1998 0.406055278039675 2883 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2779 methotrexate 400 µM -0.23901680984732 0.399303427137504 no 1999 0.405546274046688 2901 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_896 0964-0007 44.5 µM -0.2391734335421 0.39923752815334 no 2000 0.405485550939329 2789 6756758
SGTC_345 1362-0200 395 µM -0.240239194515101 0.39878918852081 no 2001 0.40507241519599 2845 1419823
SGTC_1208 2323-2347 50.3 µM -0.240735063045984 0.398580634207271 no 2002 0.404880230808926 2992 5412760
SGTC_1662 st014054 52 µM -0.241985456277595 0.398054867672323 no 2003 0.404395716296599 2842 2838777
SGTC_1804 st050076 49.1 µM -0.242349570829625 0.397901799187894 no 2004 0.404254653179278 2952 3895976
SGTC_1863 st057641 20.1 µM -0.244071145331679 0.397178287373061 no 2005 0.403587859767336 2827 3921635
SGTC_1012 4112-3522 18 µM -0.244702275293716 0.396913136093866 no 2006 0.403343483083166 2997 3112398
SGTC_2062 5245942 200 µM -0.244809751864558 0.396867987618236 no 2007 0.403301871374275 2808 1376160
SGTC_583 1488-1091 88.9 µM -0.245120707709598 0.39673736989096 no 2008 0.403181484753226 2891 4303273
SGTC_394 menadione 8.33 µM -0.247257467319377 0.395840133105134 no 2009 0.40235448655685 2960 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1134 3477-0009 42.5 µM -0.247347060398903 0.395802524508839 no 2010 0.402319820523512 3114 3973534
SGTC_2029 5175081 200 µM -0.2473737688339 0.395791313264173 no 2011 0.402309486442053 2830 1380876
SGTC_2836 9010338 19.48 µM -0.247587791755379 0.395701477219475 no 2012 0.402226678728518 2862 2994051
SGTC_2415 st077333 57.7 µM -0.249319746384678 0.394974694117336 no 2013 0.401556729048531 3096 2766255
SGTC_2382 9035899 200 µM -0.249992129058406 0.394692639308963 no 2014 0.401296717762234 2865 6462679
SGTC_770 0389-1121 67.2 µM -0.251340208623774 0.394127305815557 no 2015 0.400775545332482 3022 6753108
SGTC_63 0099-0242 26.702 µM -0.251573983658751 0.394029292077884 no 2016 0.400685184998023 3005 3898502 YLR359W ADE13
SGTC_2177 5811945 192 µM -0.252002616815068 0.393849598548419 no 2017 0.40051952056987 3007 5343475
SGTC_1133 3473-0247 50 µM -0.252286819444788 0.393730466294452 no 2018 0.400409687633296 2907 711311
SGTC_49 0717-0965 32.132 µM -0.253771668177578 0.393108208344478 no 2019 0.399835981292328 3145 5889349 YGL099W LSG1
SGTC_214 4373-3496 70 µM -0.254608201879857 0.392757760943678 no 2020 0.399512861868779 2894 3779166
SGTC_2719 novobiocin 32.65 µM -0.256706033007403 0.391879303600808 no 2021 0.398702856959762 2972 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1269 0831-0796 3.05 µM -0.257340073654555 0.391613910142224 no 2022 0.398458129767104 2981 927758
SGTC_2795 7780010 54.55 µM -0.258009262647367 0.391333859180087 no 2023 0.398199879316517 3003 953673
SGTC_1735 st034310 56.75 µM -0.258610975200259 0.391082094725124 no 2024 0.397967707139592 3060 871153
SGTC_955 1216-0110 33 µM -0.258686807242207 0.39105036883623 no 2025 0.397938449732883 2811 3619719
SGTC_246 cycloheximide 667 µM -0.259447447433159 0.390732179565385 no 2026 0.397645012431868 2850 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2772 vinpocetine 57.06 µM -0.260345215326736 0.390356721478078 no 2027 0.39729874896562 3066 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1231 0242-0792 125 µM -0.260947631995184 0.390104840367799 no 2028 0.397066445973574 2836 3707635
SGTC_1964 st076914 61 µM -0.2626388572306 0.389397955917095 no 2029 0.396414473696673 2849 24208661
SGTC_2552 juarezic acid 87.02 µM -0.26324409135727 0.389145073881314 no 2030 0.396181224426089 2824 1549512
SGTC_1336 1486-0901 104 µM -0.263400889555953 0.389079567304203 no 2031 0.396120802520246 2944 5006114
SGTC_2423 st077119 87.2 µM -0.264222250543143 0.388736473673544 no 2032 0.395804333335813 2829 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1546 5-methoxyflavanone 78.7 µM -0.264494437707333 0.388622796529253 no 2033 0.395699475160043 2942 147795
SGTC_1092 toremifene 6.32 µM -0.265107216012931 0.388366908697665 no 2034 0.395463434299249 2868 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3038 9091290 49.47 µM -0.266470086384442 0.387797966529133 no 2035 0.39493859720739 3036 25236843
SGTC_1485 3909-9022 254 µM -0.266509206749701 0.387781638939632 no 2036 0.39492353488706 2892 714516
SGTC_3066 9117245 49.47 µM -0.267731127367288 0.387271748375574 no 2037 0.394453144014059 2923 17176980
SGTC_1955 wogonin 32.4 µM -0.268152756145106 0.387095853594266 no 2038 0.394290869363858 3103 5281703 A flavanone.
SGTC_755 1995-0008 37.3 µM -0.268297076545174 0.387035651440313 no 2039 0.3942353281692 2959 689533
SGTC_114 0364-0001 490.298 µM -0.270017997866956 0.386317992014335 no 2040 0.393573203711381 2949 4003655
SGTC_1458 k015-0034 6.33 µM -0.270039612086454 0.386308980909031 no 2041 0.393564889592853 2936 3598957
SGTC_2012 4023501 200 µM -0.273170295571825 0.385004429084395 no 2042 0.392361156294066 2971 3477460
SGTC_852 0418-0143 439 µM -0.273571473951588 0.384837352265844 no 2043 0.392206979214985 2991 5369229
SGTC_1891 st059073 26.2 µM -0.274056279972351 0.384635475983791 no 2044 0.392020685732714 3092 688754
SGTC_2776 terbinafine 19.92 µM -0.275586737295934 0.383998389372242 no 2045 0.391432748720666 2921 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3197 9113331 49.47 µM -0.276123070520872 0.38377520289572 no 2046 0.391226770765783 3118 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_681 1642-0006 26.6 µM -0.278036678364314 0.382979200271799 no 2047 0.390492101543609 2969 4446530
SGTC_633 0437-0093 97.7 µM -0.278139141864424 0.382936592476294 no 2048 0.390452774922865 2903 2831118
SGTC_1788 fluconazole 20 µM -0.278307030924536 0.382866781577954 no 2049 0.390388339673896 2997 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1674 st016616 23.6 µM -0.27872084415102 0.382694727814671 no 2050 0.390229532427215 2839 625830
SGTC_1349 flufenamic acid 69 µM -0.280803295120111 0.381829245897565 no 2051 0.389430638067058 2876 3371 A non-steroidal anti-inflammatory.
SGTC_422 cantharidin 155 µM -0.281095910340225 0.381707680067636 no 2052 0.389318418920199 2859 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1509 1326-1131 80 µM -0.281106949194355 0.381703094247845 no 2053 0.389314185654607 3007 768313
SGTC_1677 st019204 53.9 µM -0.28135779705955 0.381598890163286 no 2054 0.389217992107152 3006 3945625
SGTC_1896 st058441 89 µM -0.282715727465186 0.381034944816708 no 2055 0.388697379563147 2949 688759
SGTC_3160 9100216 49.47 µM -0.285171256411135 0.380015811404218 no 2056 0.387756470255609 2876 17191039
SGTC_807 1315-0151 48 µM -0.285218391120206 0.379996256915708 no 2057 0.387738415609108 3148 4011080
SGTC_1705 st027868 56.3335 µM -0.287331566348808 0.379119892727591 no 2058 0.386929227381294 2990 292948
SGTC_2859 9028643 45.46 µM -0.287501147723679 0.379049591744635 no 2059 0.386864311630736 2985 17151580
SGTC_2526 patulin 37.61 µM -0.288493231979215 0.378638397454336 no 2060 0.38648460524794 3060 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2050 5263056 171 µM -0.288590762044097 0.378597981071988 no 2061 0.386447282839354 3076 763468 YGL055W OLE1
SGTC_392 N-ethylmaleimide 8.33 µM -0.289005308114631 0.378426208326871 no 2062 0.386288657760468 2950 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3092 9117248 49.47 µM -0.290336842223718 0.377874631888343 no 2063 0.385779278037931 2940 17141857
SGTC_2365 9042475 200 µM -0.290779336383758 0.377691387568701 no 2064 0.385610044993797 3043 6464479
SGTC_1875 nocodazole 6 µM -0.292057802737556 0.377162107787242 no 2065 0.385121214646819 2990 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2507 purpurin 79.67 µM -0.292327473432785 0.377050494664192 no 2066 0.385018127495222 2898 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_98 0074-0023 107.663 µM -0.292820727370092 0.376846369987179 no 2067 0.384829592096165 2995 3563821
SGTC_663 1486-0733 13.9 µM -0.293061122575955 0.376746899028643 no 2068 0.384737716216511 2918 722445 YPR165W RHO1
SGTC_1395 3486-0190 4.35 µM -0.293149910238417 0.376710162453246 no 2069 0.384703784378475 3080 6748079
SGTC_2623 humulene 100 µM -0.293367968155373 0.376619944058311 no 2070 0.384620453283887 3003 6187145 An anti-inflammatory.
SGTC_1619 st003326 88.7 µM -0.293516087743275 0.376558665505753 no 2071 0.38456385224568 3086 2849032
SGTC_3051 9093778 49.47 µM -0.294403404107676 0.37619163904519 no 2072 0.38422483300691 2960 17217378
SGTC_581 0958-0271 211 µM -0.294960735140265 0.375961163785872 no 2073 0.384011937371563 2927 4591145
SGTC_497 capsazepine 133 µM -0.295347583941571 0.375801214708079 no 2074 0.383864185046217 2933 2733484 A calcium channel blocker.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.296120975349945 0.375481507152173 no 2075 0.383568847970915 2999 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_158 k038-0087 26.446 µM -0.296200548269336 0.375448617835509 no 2076 0.383538465078683 2892 X158
SGTC_476 mead acid 10 µM -0.2962341810519 0.375434716905533 no 2077 0.383525623472713 2915 5312531 An omega 9 fatty acid.
SGTC_579 4491-1009 110 µM -0.297457937193648 0.374929030402646 no 2078 0.383058458324721 3048 1271041
SGTC_1427 4048-4900 550 nM -0.297658544612863 0.374846154905727 no 2079 0.382981893262045 3051 24132586
SGTC_3027 9089541 49.47 µM -0.298494127104356 0.374501018943841 no 2080 0.382663028915776 3029 9943819
SGTC_3091 9116372 49.47 µM -0.299709149236432 0.373999335495186 no 2081 0.382199509586444 3092 17169793
SGTC_125 0133-0007 11.75 µM -0.30118765171981 0.373389148654646 no 2082 0.381635702706051 3074 26541
SGTC_116 0155-0182 31.788 µM -0.301935602153814 0.373080585800453 no 2083 0.381350577486887 2953 771486
SGTC_364 0083-0097 67.7 µM -0.303855009244778 0.372289117782877 no 2084 0.38061917774354 3077 5207356
SGTC_2361 9034121 116 µM -0.303972442821556 0.372240711485394 no 2085 0.380574442906082 2960 6496917
SGTC_1999 st074831 12.5 µM -0.304366798296645 0.372078172339269 no 2086 0.380424229858223 2967 17112523
SGTC_2333 9017922 200 µM -0.304998780417819 0.37181773957391 no 2087 0.380183540590722 3079 3163164
SGTC_1379 2144-0755 36.5 µM -0.305114274771834 0.37177015197653 no 2088 0.380139559782167 3120 5392327
SGTC_688 0527-0193 473 µM -0.306260061142003 0.3712981553063 no 2089 0.379703322831172 2964 4007154
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.30696334949471 0.371008537607781 no 2090 0.379435634580016 2876 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_431 k089-0097 107 µM -0.307686852190323 0.370710671768106 no 2091 0.379160312569464 3062 5499420
SGTC_2225 6654152 15.4 µM -0.308597990934567 0.370335666458146 no 2092 0.378813674660883 3010 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1046 2001-0062 216 µM -0.309009045702748 0.370166525372754 no 2093 0.378657322936084 2929 739778
SGTC_236 1509-0011 5.31 µM -0.310509562972404 0.369549304850706 no 2094 0.378086744216801 3068 3107280
SGTC_254 nsc-64875 3.808 µM -0.312666573103665 0.368662632560244 no 2095 0.377266996957008 3105 56993
SGTC_2153 5569715 200 µM -0.313391489710819 0.368364801044573 no 2096 0.376991624523961 2980 2054701
SGTC_2722 naftopidil 47.16 µM -0.313780775106397 0.368204896016625 no 2097 0.376843773367337 3073 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2235 salicylic acid 500 µM -0.314445923298243 0.367931728897685 no 2098 0.376591190921694 2974 338 A COX inhibitor and kinase inhibitor.
SGTC_2680 butyl paraben 22.24 µM -0.315257099476607 0.367598680500738 no 2099 0.376283227513464 2976 7184 An antifungal and steroid mimetic.
SGTC_215 1287-0124 461.5 µM -0.31542033197458 0.367531673394288 no 2100 0.376221265732096 3002 5560863
SGTC_1149 3909-7961 23.3 µM -0.315745894823969 0.367398041557864 no 2101 0.376097694144995 2993 735261
SGTC_400 oxethazaine 37.5 µM -0.31575634489146 0.367393752447027 no 2102 0.376093727897157 3026 4621 A local anesthetic.
SGTC_1215 3852-0577 11.2 µM -0.316525711881459 0.367078020033025 no 2103 0.375801756175039 3126 2884876
SGTC_637 1181-0519 7.26 µM -0.31657712028191 0.36705692628213 no 2104 0.375782249423095 2972 6252091 YGR060W ERG25
SGTC_1911 st060208 74.3 µM -0.317002532458545 0.366882387755738 no 2105 0.375620840330619 3072 688783
SGTC_2104 5389443 200 µM -0.317061910179384 0.36685802839345 no 2106 0.375598313077231 3143 2244536
SGTC_1335 1486-0900 202 µM -0.317371509670175 0.366731025702502 no 2107 0.375480861312114 2930 X1335
SGTC_2866 9034245 58.44 µM -0.317686368176324 0.36660188064065 no 2108 0.375361426286996 3032 6462273
SGTC_1277 0873-0036 22 µM -0.318346582405893 0.36633113056406 no 2109 0.375111026551274 3045 5965735
SGTC_2450 5739737 12.93 µM -0.318673284127234 0.36619717665351 no 2110 0.374987137705138 3062 2262825
SGTC_1300 1094-0077 113 µM -0.319138047555407 0.366006642919197 no 2111 0.374810916585798 2973 5532636
SGTC_2990 9074105 71.4286 µM -0.32062832832311 0.365395912629907 no 2112 0.374246033618225 3054 6502001
SGTC_3174 9107204 49.47 µM -0.321096042683734 0.36520430939384 no 2113 0.374068804569497 3097 3938802
SGTC_1745 st081495 74 µM -0.321252598327079 0.365140182532605 no 2114 0.374009487537092 2985 13842402 YBL026W LSM2
SGTC_3060 1327-0027 12.5 µM -0.321727617562386 0.364945632674059 no 2115 0.373829526779776 3038 16000455 YPR107C YTH1
SGTC_2197 6588183 93.1375 µM -0.321755192566692 0.364934340065513 no 2116 0.373819080849846 2984 884136
SGTC_2661 dactinomycin 12.96 µM -0.321781615306561 0.36492351944609 no 2117 0.373809071506294 3002 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1524 corynanthine 62.1 µM -0.321980717307637 0.364841986812876 no 2118 0.373733651318309 3140 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3137 9097352 49.47 µM -0.322308984686046 0.364707574068147 no 2119 0.373609313616614 3273 44120435
SGTC_699 0375-0592 111 µM -0.322382537305539 0.364677459406331 no 2120 0.373581455924302 3109 762578
SGTC_3307 9126885 69.2785 µM -0.323237074951921 0.364327647156812 no 2121 0.373257852452995 2970 24824909
SGTC_2234 tolnaftate 200 µM -0.323696835351995 0.364139487054084 no 2122 0.373083783499051 3004 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1084 voriconazole 435 nM -0.324257893153736 0.363909914657794 no 2123 0.372871397637403 3094 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_53 0973-0023 39.979 µM -0.324547243003546 0.363791538206257 no 2124 0.372761880673413 3040 674768
SGTC_704 1310-0270 142 µM -0.326066432364742 0.363170233381091 no 2125 0.372187046693765 3042 5718033
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.32781051824672 0.36245739611897 no 2126 0.371527466991253 3030 688761
SGTC_2906 7926292 26.41 µM -0.32897370112243 0.361982248439294 no 2127 0.371087783067963 3104 2966319
SGTC_195 4234-0266 16.654 µM -0.328974583324622 0.361981888149806 no 2128 0.371087449658702 3018 2303354
SGTC_2437 5741531 144.16 µM -0.329510571179597 0.361763014478201 no 2129 0.370884902524497 3166 2262990
SGTC_658 3253-0951 102 µM -0.329979368640098 0.36157161544796 no 2130 0.370707775627609 3029 1184878
SGTC_2610 ononetin 44.17 µM -0.330017977234796 0.361555854005336 no 2131 0.370693189268025 3036 259632
SGTC_2989 9073649 71.4286 µM -0.330223071612771 0.36147213090649 no 2132 0.370615707555703 3039 21367202
SGTC_3345 9148410 3.559 µM -0.330469990037123 0.361371343302895 no 2133 0.370522432280867 3117 4903596
SGTC_885 0865-0106 16.8 µM -0.330959821081598 0.361171431669347 no 2134 0.370337417483442 2987 2793380
SGTC_1241 0364-0022 50.8 µM -0.331288872960943 0.361037159098446 no 2135 0.370213147656838 3016 4563895
SGTC_3145 9085516 49.47 µM -0.331552034275135 0.360929786085258 no 2136 0.370113771828166 3088 25236195
SGTC_2460 5552655 174.22 µM -0.332352422099327 0.360603285514506 no 2137 0.369811580095415 3115 5401989
SGTC_520 3584-0023 682 µM -0.334524086887221 0.359717915124156 no 2138 0.368992059038145 3034 1340790
SGTC_2824 7998404 51.95 µM -0.336843227951161 0.358773250515267 no 2139 0.368117542090514 2975 837851
SGTC_901 1112-0062 60.1 µM -0.337945725399725 0.358324468369503 no 2140 0.367702044340746 3004 1908457
SGTC_2983 9022671 12.99 µM -0.338090784450465 0.35826543524382 no 2141 0.367647387509776 3193 6405161
SGTC_821 1114-0266 29.2 µM -0.338444702216361 0.358121419345926 no 2142 0.367514046008585 3069 3123235
SGTC_1739 st037196 92.5 µM -0.338670034099441 0.35802973801495 no 2143 0.367429158642704 3195 612214
SGTC_1836 st055642 81 µM -0.340211705479026 0.357402694305234 no 2144 0.366848551853218 3020 8571
SGTC_2487 5918373 44.05 µM -0.341738271203948 0.356782173637723 no 2145 0.366273933965464 3126 2876279
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.343533702099213 0.356052849055296 no 2146 0.365598495563959 3114 140250 A respiratory chain inhibitor.
SGTC_2773 thioridazine 9.09 µM -0.344694176212531 0.355581731068398 no 2147 0.365162148417184 3040 5452 An antipsychotic.
SGTC_2217 6934799 96.0675 µM -0.344893328131113 0.355500903462827 no 2148 0.365087283301037 3085 675606
SGTC_994 3910-0338 138 µM -0.345043601972282 0.355439917767972 no 2149 0.365030795817544 3192 3479481
SGTC_2418 pentamidine 31.67 µM -0.346635737022247 0.35479400856484 no 2150 0.364432497176821 3104 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2464 5717415 7.67 µM -0.346844053424554 0.354709528040204 no 2151 0.364354239629467 3029 5285744
SGTC_2707 st078556 66.6 µM -0.346990553913586 0.354650120587705 no 2152 0.364299207652 3072 17250899
SGTC_673 1082-0474 110 µM -0.347764412729072 0.354336371578502 no 2153 0.364008558948073 3058 3098046
SGTC_1043 0916-0009 19.3 µM -0.349036242831321 0.353820942637428 no 2154 0.363531050342957 3199 3101130
SGTC_3190 9110366 49.47 µM -0.350479170920051 0.353236497878458 no 2155 0.362989559645616 3131 17123768
SGTC_1565 sinapyl alcohol 95.1 µM -0.353432504924699 0.352041357059237 no 2156 0.361882110398094 3117 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1460 k062-0059 9.15 µM -0.353724242122152 0.351923377322617 no 2157 0.361772776550985 2933 1373085
SGTC_1313 1220-0047 237 µM -0.355681377866415 0.351132272570374 no 2158 0.361039596275238 3086 3528706
SGTC_1785 bathophenanthroline 24 µM -0.356086417220061 0.350968629761073 no 2159 0.36088792446878 3038 72812 An iron chelator.
SGTC_355 1311-2252 105 µM -0.356367310005587 0.350855160510232 no 2160 0.360782753665639 3044 5338538
SGTC_2111 5486399 200 µM -0.356914227099683 0.350634266435875 no 2161 0.36057800926742 3037 689674
SGTC_1473 k844-0725 134 µM -0.357425521703043 0.350427805574188 no 2162 0.36038663668045 3076 54682906
SGTC_1089 terbinafine 2.25 µM -0.358426927039238 0.350023565957967 no 2163 0.360011921781282 3140 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1286 0929-0070 131 µM -0.358664013112344 0.349927885729534 no 2164 0.359923226446669 3148 1420408
SGTC_965 1291-5240 308 µM -0.360266189995281 0.349281549276925 no 2165 0.359324040289713 3166 2834598
SGTC_148 3253-0744 288.01 µM -0.362219152713888 0.348494292698623 no 2166 0.358594134087177 3061 6893655
SGTC_363 0455-0021 3.06 µM -0.362478072486289 0.34838996873141 no 2167 0.358497403326074 3018 4597466
SGTC_397 arbidol 50 µM -0.362607865587051 0.348337676803734 no 2168 0.358448916874302 3192 131410 A RNA synthesis inhibitor.
SGTC_261 5-fluorouridine 15.376 µM -0.362974127555049 0.348190130237023 no 2169 0.358312105705483 3260 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_412 gemfibrozil 100 µM -0.364708942995311 0.347491582087823 no 2170 0.357664341118382 3120 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1456 k015-0012 13 µM -0.365358469230557 0.347230174143336 no 2171 0.357421919150529 3250 2989616
SGTC_870 0573-2213 57.6 µM -0.36542365765103 0.347203942460474 no 2172 0.357397592122299 3068 3916321
SGTC_2319 6033012 152.6 µM -0.365436746974849 0.347198675432427 no 2173 0.357392707515589 3043 847246
SGTC_532 1548-0774 215 µM -0.365867024027982 0.34702555219104 no 2174 0.357232151944453 3264 5932993
SGTC_83 0170-0301 39.027 µM -0.366453692601189 0.34678955580396 no 2175 0.357013280444474 3079 3089716
SGTC_1806 st050005 60.3 µM -0.368177135289844 0.346096618711292 no 2176 0.356370579073455 3057 5194765
SGTC_1713 st033146 12.748 µM -0.369180456185666 0.345693454863259 no 2177 0.355996611131836 3219 674619
SGTC_2737 bleomycin 30.5 nM -0.369973979654101 0.345374717654151 no 2178 0.35570093908225 3080 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_185 k048-0037 25.491 µM -0.370869048341625 0.345015324006416 no 2179 0.355367534788087 3182 6827589
SGTC_2380 9035439 200 µM -0.370968956668333 0.344975216847539 no 2180 0.355330326778639 3198 6462575
SGTC_2298 7976326 193.81 µM -0.371505457249077 0.344759874065488 no 2181 0.355130546017881 3022 2235818
SGTC_1647 st011722 22.4 µM -0.371805811912985 0.344639338442283 no 2182 0.355018718071444 3189 2854783
SGTC_956 1185-0240 191 µM -0.372826617941491 0.344229795728894 no 2183 0.35463874531154 3061 1416193
SGTC_2985 9022375 71.43 µM -0.373230752137851 0.344067709366551 no 2184 0.354488355111058 3243 4939335
SGTC_3289 9119912 71.43 µM -0.373696905367875 0.343880784568701 no 2185 0.354314913979371 3174 17014829
SGTC_329 k048-0121 21.3 µM -0.374208671195653 0.34367561331441 no 2186 0.354124536608225 3134 6832902
SGTC_931 2812-0076 566 µM -0.374303901087499 0.343637439923096 no 2187 0.354089115020213 3020 3450959
SGTC_3046 9092212 49.47 µM -0.374843399615585 0.34342120928001 no 2188 0.353888467687579 3125 25236637
SGTC_929 2805-0021 398 µM -0.374877789210866 0.34340742769002 no 2189 0.353875679072988 3137 3098024
SGTC_1987 st072290 61.9 µM -0.375160060132297 0.343294315818535 no 2190 0.353770715938221 3114 54697379
SGTC_2755 lomerizine 42.69 µM -0.375337363626363 0.343223273770648 no 2191 0.353704790881821 3101 3949 A calcium channel blocker.
SGTC_1287 0971-0001 34.6 µM -0.375984956573038 0.342963843009637 no 2192 0.353464039900097 3104 4665869
SGTC_2757 clomiphene 4.22 µM -0.376148594793531 0.342898299978282 no 2193 0.353403214566424 3269 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2119 5528445 120.635 µM -0.376907435729318 0.342594418534002 no 2194 0.353121197677844 3207 791935
SGTC_6 0844-0013 19.835 µM -0.377949137365253 0.342177430074498 no 2195 0.352734189348475 3165 1584900
SGTC_908 3448-7491 47.7 µM -0.378241579856563 0.342060401228158 no 2196 0.352625569794091 3043 1203031
SGTC_191 3914-0123 66.505 µM -0.379222105840419 0.341668127747745 no 2197 0.35226146865853 3032 3144412
SGTC_3059 1327-0034 3 µM -0.379728191627861 0.341465727721188 no 2198 0.352073595516483 3068 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2419 paclitaxel 166.5 µM -0.380124077671872 0.341307431898028 no 2199 0.351926656752344 3039 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3342 9147791 14.508 µM -0.380246825929305 0.341258356431629 no 2200 0.351881101471691 3069 1838168
SGTC_922 1866-0035 480 µM -0.381018080006264 0.340950066027386 no 2201 0.351594916380111 3061 3156169
SGTC_3093 9117344 49.47 µM -0.381075409738042 0.340927154072728 no 2202 0.351573646701393 3201 24824913
SGTC_3239 9133757 49.47 µM -0.381135791641133 0.340903022945399 no 2203 0.35155124515102 3067 17036923
SGTC_2078 5212016 200 µM -0.382177080873333 0.340486982804283 no 2204 0.351165010348472 3133 1899708
SGTC_1000 4048-0884 8.67 µM -0.382734686836601 0.340264274813215 no 2205 0.350958246408049 3193 13040088
SGTC_2388 9080168 200 µM -0.383683784318274 0.339885333126349 no 2206 0.350606416342955 3058 15943073
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.383921475159381 0.339790456731098 no 2207 0.350518324487876 3267 165506
SGTC_1181 1222-0449 220 µM -0.384154013351367 0.339697646881801 no 2208 0.350432150062135 3252 658318
SGTC_2937 9044753 11.33 µM -0.385048518374897 0.339340725724491 no 2209 0.350100734557059 3025 6465530 YGL099W LSG1
SGTC_2614 arthonioic acid 13.39 µM -0.385057801191393 0.339337022493895 no 2210 0.35009729585703 3089 6710684
SGTC_3349 9149703 23.001 µM -0.385421819376374 0.339191815521611 no 2211 0.349962459694368 3066 4910494
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.385826502061172 0.339030415498434 no 2212 0.349812583178126 3212 688664
SGTC_129 0088-0017 176.636 µM -0.387148761133617 0.338503263588082 no 2213 0.349323040310998 3201 182446
SGTC_2663 amphotericin b 100 µM -0.387474977275136 0.33837325790286 no 2214 0.349202303097632 3141 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2838 9002687 71.43 µM -0.387545847052995 0.338345016984876 no 2215 0.349176075206667 3046 6457060
SGTC_1085 doxorubicin 7.67 µM -0.387716890863202 0.338276861434086 no 2216 0.349112777306848 3199 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_154 3389-1638 511.116 µM -0.389067661260699 0.337738808442481 no 2217 0.348613047535177 3143 5238686
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.389379328608664 0.337614708866107 no 2218 0.348497780621738 3097 4330530
SGTC_334 1502-1024 68.5 µM -0.389661309286395 0.337502445128694 no 2219 0.348393505065495 3184 3296216
SGTC_2157 5649910 96.377 µM -0.389846717254829 0.337428637342545 no 2220 0.348324948032176 3071 2858091
SGTC_1830 st055982 50.3 µM -0.391203250827674 0.336888814642747 no 2221 0.347823502795877 3203 455313 An antimicrobial agent.
SGTC_2390 9097792 176.6 µM -0.391409597462735 0.336806729894355 no 2222 0.347747249658877 3114 4497149
SGTC_595 3909-8003 73.7 µM -0.392835520831856 0.336239709811011 no 2223 0.347220483775593 3207 699517
SGTC_3139 9095020 49.47 µM -0.393929369467393 0.33580499191218 no 2224 0.346816593128727 3015 25236292
SGTC_1189 1431-2119 7.28 µM -0.395420452418309 0.335212758731713 no 2225 0.346266308751802 3153 3107275
SGTC_1928 4'-methoxychalcone 40.3 µM -0.396667834358668 0.33471763389976 no 2226 0.345806211393056 3292 641818
SGTC_59 0330-0160 1.33 µM -0.396878172407061 0.334634172439928 no 2227 0.345728650523024 3154 4293482
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.396896631339326 0.334626848384987 no 2228 0.34572184421353 3056 23665772 A membrane-active detergent.
SGTC_2047 4141938 200 µM -0.397002256390562 0.334584940146369 no 2229 0.345682898348462 3131 3807862
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.397694787675699 0.334310219598171 no 2230 0.345427590021494 3279 5393153
SGTC_3134 9127454 49.47 µM -0.3979670227818 0.334202250815849 no 2231 0.345327247173385 3224 24262820
SGTC_202 3594-0513 34.79 µM -0.401968513135725 0.332616841428833 no 2232 0.343853599586615 3128 708429
SGTC_1554 st069299 38.7 µM -0.403826859412914 0.331881570463084 no 2233 0.343170021874924 3192 24207999
SGTC_1812 st052057 4.327 µM -0.404070594019756 0.331785182669061 no 2234 0.343080404059392 3086 3645418
SGTC_2638 epoxomicin 18 µM -0.40567725019145 0.331150089932209 no 2235 0.342489880036745 3229 9915668 A protesome inhibitor.
SGTC_1737 st035557 69.7 µM -0.408443913858952 0.330057597975853 no 2236 0.341473899508269 3150 5716916
SGTC_3022 9087993 49.47 µM -0.409703609755781 0.329560652009908 no 2237 0.341011690882754 3209 17173644
SGTC_2583 asiatic acid 100 µM -0.410401778561833 0.32928535617332 no 2238 0.340755620904441 3293 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1404 3909-7820 48.3 µM -0.410637033057079 0.3291926135066 no 2239 0.340669352254799 3230 23741373
SGTC_1447 4239-0816 81.9 µM -0.411308018120443 0.32892815370554 no 2240 0.340423345469204 3128 1341554
SGTC_3129 9127257 49.47 µM -0.412827093235979 0.32832974702943 no 2241 0.339866649918008 3114 837894
SGTC_2698 st077697 67.5 µM -0.413501922123287 0.328064053943433 no 2242 0.339619457227919 3150 3154499
SGTC_1105 epirubicin 18.1 µM -0.41435068885344 0.327730001690623 no 2243 0.339308648301478 3112 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_615 k087-0205 167 µM -0.415005624999068 0.32747233024267 no 2244 0.339068892668579 3143 9642773
SGTC_305 1682-2595 20.8 µM -0.418343951632111 0.326160211748174 no 2245 0.33784782963686 3200 226033
SGTC_733 4069-0007 56.1 µM -0.421205700618069 0.325037120357397 no 2246 0.336802441013318 3233 5717425 YNL287W SEC21
SGTC_2194 5927483 104.545 µM -0.421479656035549 0.32492968987039 no 2247 0.33670243182938 3135 760979
SGTC_2135 5326629 150.42 µM -0.421879821686566 0.324772792723011 no 2248 0.336556369543091 3156 5020077
SGTC_3334 9142812 21.919 µM -0.422253489311271 0.324626312996874 no 2249 0.336420001418222 3242 45283678
SGTC_1351 1496-0003 46.5 µM -0.42281627261991 0.324405750090913 no 2250 0.336214657081733 3277 3891978
SGTC_3237 9133362 49.47 µM -0.423887885323247 0.323985939930088 no 2251 0.335823789855178 3233 43845137
SGTC_1683 st010134 710 nM -0.424039268937679 0.32392665259379 no 2252 0.335768587478021 3107 3818134
SGTC_528 3492-0019 172 µM -0.424043922700292 0.323924830081632 no 2253 0.335766890529101 3229 2869262
SGTC_1874 staurosporine 7.6 µM -0.424625484513233 0.323697111373298 no 2254 0.335554856081463 3244 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1893 st059353 36.1 µM -0.424757360281527 0.323645482737084 no 2255 0.335506782134162 3203 3112488
SGTC_178 4092-0806 87.505 µM -0.425474504645299 0.32336478410737 no 2256 0.335245401729399 3245 2169044
SGTC_1230 0170-0365 3.77 µM -0.427109505024292 0.322725201965395 no 2257 0.334649785080193 3306 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_660 4031-1742 102 µM -0.427878969066978 0.322424382989634 no 2258 0.334369619717661 3195 6738706
SGTC_738 1315-0003 72.4 µM -0.428013903420086 0.322371642902021 no 2259 0.334320499005756 3291 6251474
SGTC_307 1501-1223 22.3 µM -0.428115017188532 0.322332124182673 no 2260 0.334283692000822 3227 2830329
SGTC_1147 3809-1045 12.3 µM -0.428157703498874 0.322315441515212 no 2261 0.334268153989532 3164 325925
SGTC_1311 1190-0148 100 µM -0.428397246540167 0.322221829923178 no 2262 0.334180964500863 3293 1961333
SGTC_2251 lansoprazole 556 µM -0.428976405182906 0.321995545740336 no 2263 0.333970197830809 3092 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.429608097331849 0.321748811320646 no 2264 0.333740372933229 3175 115019
SGTC_179 1273-0063 6.77 µM -0.430399700007221 0.321439727948707 no 2265 0.333452456762904 3132 3108139
SGTC_552 k242-0005 476 µM -0.430440472518309 0.321423811558319 no 2266 0.333437629925928 3270 4088318
SGTC_1200 1643-0193 18.4 µM -0.431079678367689 0.32117432725504 no 2267 0.333205218107586 3272 5403974
SGTC_839 0122-0028 230 µM -0.434543531378504 0.319823778854867 no 2268 0.331946895369048 3166 759448
SGTC_2878 9043973 25.97 µM -0.435227513111064 0.319557377353043 no 2269 0.331698646945476 3299 6465167
SGTC_1982 st072467 71.9 µM -0.436499230870227 0.319062308248491 no 2270 0.331237278569311 3114 3163533
SGTC_572 0960-0087 17.7 µM -0.439607704852481 0.31785356445972 no 2271 0.330110629675576 3214 6796365
SGTC_732 3970-1727 52.7 µM -0.439855710312497 0.317757209771674 no 2272 0.330020807648149 3268 1275699
SGTC_3043 9092303 49.47 µM -0.440200145456653 0.31762341084708 no 2273 0.329896077200997 3221 25236084
SGTC_3044 9093193 49.47 µM -0.440330211005159 0.317572891910984 no 2274 0.329848981425947 3256 25236277
SGTC_1870 st057514 26.5 µM -0.44038835044431 0.317550310991125 no 2275 0.329827930436425 3140 5393161
SGTC_711 k292-0785 179 µM -0.441815422939457 0.316996259787545 no 2276 0.32931138855105 3172 4146315
SGTC_1801 st050089 28.441 µM -0.442573783540566 0.316701998207318 no 2277 0.329037025450518 3247 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1848 st056003 16.4 µM -0.442806940594981 0.316611551134392 no 2278 0.328952691344152 3289 146492
SGTC_3285 9112818 20.8695 µM -0.443027528634228 0.316525989969643 no 2279 0.328872911530319 3189 17017947 YPR165W RHO1
SGTC_2482 5981709 142.65 µM -0.444077965211703 0.316118683880565 no 2280 0.328493108394433 3202 877755
SGTC_724 3910-0327 137 µM -0.445652406769285 0.315508613020362 no 2281 0.32792417419278 3263 2885483
SGTC_2688 kanamycin b 96.69 µM -0.445787133158421 0.315456432022287 no 2282 0.327875508496948 3369 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2785 7756463 72.73 µM -0.446234125109859 0.315283333534028 no 2283 0.327714067568409 3145 2201551
SGTC_563 tetrahydrosecaminediol 614 µM -0.447218582778402 0.314902243426543 no 2284 0.327358622713982 3322 334274 A psychoactive constituent of the cannabis plant.
SGTC_2979 9012552 45.46 µM -0.447584787085085 0.314760533552061 no 2285 0.327226442173222 3288 17100905
SGTC_743 1275-0778 158 µM -0.45087821967661 0.313487303488628 no 2286 0.326038661012286 3280 2849257 YMR203W TOM40
SGTC_816 0325-0417 81.3 µM -0.451289436373883 0.313328484021831 no 2287 0.325890478682912 3269 68101
SGTC_1144 3486-0183 12.5 µM -0.452040055914731 0.313038670188559 no 2288 0.325620063133793 3232 6744069
SGTC_2326 6164455 177.58 µM -0.452124394707462 0.313006114235562 no 2289 0.325589685268397 3227 2888790
SGTC_1114 scopoletin 1.73284 µM -0.452136864012978 0.313001301033027 no 2290 0.325585194065914 3304 5280460 A coumarin with genotoxic properties.
SGTC_1166 k206-0078 225 µM -0.452144740338968 0.312998260755653 no 2291 0.3255823571788 3213 5404595
SGTC_1062 mesoridazine 14.2 µM -0.452300457483533 0.312938156241616 no 2292 0.325526273209913 3236 4078 A neuroleptic.
SGTC_186 3455-3465 67.277 µM -0.452601287266961 0.312822054476792 no 2293 0.325417935838335 3152 755278
SGTC_1701 st028638 40.4 µM -0.452743983438431 0.312766989035801 no 2294 0.325366552040599 3307 3490878
SGTC_3272 9137413 49.47 µM -0.453168319924523 0.312603265283052 no 2295 0.325213771340129 3223 17614870
SGTC_3223 9129970 49.47 µM -0.45345144421985 0.312494046660011 no 2296 0.325111849877052 3176 17248386
SGTC_1150 3909-7983 10.9 µM -0.453708067080697 0.312395065513188 no 2297 0.32501947992728 3215 23965914
SGTC_677 0929-0063 136 µM -0.453959159043922 0.312298230770669 no 2298 0.324929111201849 3257 1539583
SGTC_3163 9099914 49.47 µM -0.456020447440944 0.311503776166431 no 2299 0.324187637297719 3279 16268368
SGTC_2131 toluylene red 5.2905 µM -0.458541007038027 0.310533502567912 no 2300 0.323281904222322 3190 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2855 9016525 58.44 µM -0.459797278993361 0.31005039976535 no 2301 0.32283086824327 3223 43811474
SGTC_1945 st075991 56.6 µM -0.460057986291357 0.309950185098795 no 2302 0.322737299810925 3222 1084980
SGTC_2466 5983409 37.09 µM -0.461759847430398 0.309296344803854 no 2303 0.322126773997064 3244 2879657
SGTC_1518 st038567 90.8 µM -0.461817092981635 0.309274362038161 no 2304 0.322106246052593 3289 77966
SGTC_2174 5790901 200 µM -0.462110958528948 0.309161525983457 no 2305 0.322000876004283 3285 786020
SGTC_781 4335-2806 94.4 µM -0.464912339929828 0.308086779660115 no 2306 0.320997116616897 3339 845254
SGTC_1626 st003712 1.76 µM -0.464931820327265 0.308079311775276 no 2307 0.32099014118744 3336 24207035
SGTC_2818 7996756 12.99 µM -0.46611692044219 0.307625148666176 no 2308 0.320565906213132 3159 2241621
SGTC_2852 9023854 51.95 µM -0.466991041671024 0.307290350041197 no 2309 0.320253143685456 3364 19798528
SGTC_3245 9134821 49.47 µM -0.467802304139802 0.306979770675906 no 2310 0.319962986365592 3223 17014901
SGTC_1751 st044839 27.194 µM -0.468201309497327 0.30682706838996 no 2311 0.319820317907979 3319 5291326
SGTC_1637 st007924 17.4 µM -0.468419553007515 0.306743559169799 no 2312 0.319742293976471 3229 683336
SGTC_1742 st038235 28.8875 µM -0.468739602676704 0.306621112736632 no 2313 0.319627887893192 3304 564103 YBR002C RER2
SGTC_2920 7982904 15.77 µM -0.470246393257783 0.306044926329096 no 2314 0.319089495968054 3278 6456808
SGTC_980 1473-0395 201 µM -0.472237228898414 0.305284379871988 no 2315 0.318378734656355 3199 768876
SGTC_1944 st076371 56.9 µM -0.472654139064362 0.305125216540884 no 2316 0.318229975325898 3208 24208455
SGTC_2495 cafestol 54.53 µM -0.472720733096764 0.305099796423491 no 2317 0.318206216365708 3367 16667697 An anti-infammatory.
SGTC_3281 9140613 49.47 µM -0.473394000840079 0.304842851068018 no 2318 0.317966054556313 3269 16013766
SGTC_1109 tnp00067 928.257 nM -0.474480457474903 0.304428419577842 no 2319 0.317578665281229 3269 676295
SGTC_1578 josamycin 24.2 µM -0.474673566425973 0.304354783960488 no 2320 0.317509830831777 3223 5282165 A P450 substrate.
SGTC_20 0481-0013 4.944 µM -0.476469651063805 0.30367028760284 no 2321 0.316869911861911 3312 182045
SGTC_3254 9136651 49.47 µM -0.476615222054084 0.303614839924382 no 2322 0.31681807098371 3262 16454030
SGTC_920 mycophenolic acid 780.421 nM -0.476658187477195 0.3035984753507 no 2323 0.316802770784155 3246 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_234 nsc-17383 10.7 µM -0.476659385537818 0.303598019041709 no 2324 0.316802344153335 3375 408974
SGTC_3120 9124077 49.47 µM -0.479215803032634 0.302625046903348 no 2325 0.315892556498482 3308 18774327 YGL155W CDC43
SGTC_1050 3232-1156 69.3 µM -0.479722684629564 0.302432293949824 no 2326 0.315712297712128 3260 700529
SGTC_3332 9141069 11.198 µM -0.480245736859287 0.302233449492683 no 2327 0.315526334222626 3201 17332883
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.480625917584384 0.30208895614907 no 2328 0.315391195895106 3273 16623 A steroid.
SGTC_794 k038-0031 316 µM -0.481194071592011 0.301873078594264 no 2329 0.315189286962479 3374 6624242
SGTC_782 0083-0095 30.5 µM -0.481464243493727 0.301770447568483 no 2330 0.315093293411209 3277 3591729 An indicator and reagent.
SGTC_1695 st026914 34.495 µM -0.483292231451498 0.301076456694693 no 2331 0.314444127618819 3238 3289191
SGTC_2553 4-methylesculetin 85.09 µM -0.48447953928819 0.300626084043221 no 2332 0.314022790888757 3299 5319502
SGTC_2666 tannic acid 100 µM -0.484935731366773 0.300453121007433 no 2333 0.313860967643636 3367 16134267 A thiamine antagonist.
SGTC_460 trequinsin 123 µM -0.485152203885147 0.300371062220926 no 2334 0.313784191708727 3361 5537 A vasodilator.
SGTC_588 3970-1144 52.9 µM -0.485531455851966 0.300227322634111 no 2335 0.313649702505745 3327 1888707
SGTC_2130 NSC 7 2.4545 µM -0.485645940350934 0.300183938187116 no 2336 0.313609109218743 3346 21448
SGTC_464 bw-b 70c 158 µM -0.486277252036436 0.299944750545769 no 2337 0.313385302724607 3365 5353454
SGTC_525 k781-2675 26.7 µM -0.486399316005509 0.299898513622745 no 2338 0.313342037713661 3362 3651118 YDL195W SEC31
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.486715715693848 0.299778678797696 no 2339 0.313229903262696 3320 3256 An antibiotic and ribosome inhibitor.
SGTC_1506 4226-2149 212 µM -0.487499617076114 0.2994818734609 no 2340 0.312952157066753 3330 991114
SGTC_3259 9138485 49.47 µM -0.487575593167039 0.299453114030613 no 2341 0.312925243413704 3512 17646153
SGTC_192 3455-0609 60.9 µM -0.487902408307391 0.299329418112492 no 2342 0.31280948429282 3383 3769639
SGTC_2105 5350118 200 µM -0.488005596891474 0.299290367188553 no 2343 0.312772938351344 3299 2133313
SGTC_157 1348-1695 65.819 µM -0.488122617078242 0.29924608459805 no 2344 0.312731495946157 3351 5380510
SGTC_2429 5902844 64.44 µM -0.491275896429851 0.298053946813632 no 2345 0.311615662684004 3342 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2396 5342950 42.78 µM -0.491290551319182 0.29804841139986 no 2346 0.311610480866385 3303 1886677
SGTC_31 0508-1974 57.237 µM -0.491830226335589 0.297844599131464 no 2347 0.311419683341509 3343 6810525
SGTC_909 3448-9333 149 µM -0.491902258363465 0.297817400510868 no 2348 0.311394220858401 3244 3344074
SGTC_368 fentichlor 4.58 µM -0.492505094458028 0.297589819658252 no 2349 0.311181160698023 3299 7329 A pesticide.
SGTC_2771 fluoxetine 41.05 µM -0.493089434672185 0.297369297109475 no 2350 0.310974697897023 3411 3386 A selective serotonin reuptake inhibitor.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.494752601011399 0.296742048313251 no 2351 0.310387383138595 3232 279621
SGTC_1408 3909-7976 48.8 µM -0.494879678493642 0.296694147060388 no 2352 0.310342528053728 3315 24152374
SGTC_1883 5-benzylidenerhodanine 20 µM -0.495426627506584 0.296488017658468 no 2353 0.310149501315215 3347 1273210
SGTC_1688 st021091 57.6 µM -0.495478634432226 0.296468421156461 no 2354 0.310131149991534 3382 3656366
SGTC_3011 9081274 71.4286 µM -0.495891051332075 0.29631304117203 no 2355 0.309985640042824 3279 6625322
SGTC_678 1218-2179 85.9 µM -0.49610267313407 0.29623332617349 no 2356 0.309910986666596 3320 6820081 YOR116C RPO31
SGTC_1361 1608-0041 5.61 µM -0.496596981179023 0.296047165519394 no 2357 0.309736641198562 3292 X1361
SGTC_1440 4100-1550 40 µM -0.498599271934597 0.295293635488515 no 2358 0.309030859080502 3322 742806
SGTC_2147 5545932 89.7195 µM -0.499245600045193 0.295050588848712 no 2359 0.308803186865478 3342 797404
SGTC_1249 0481-0015 10.2 µM -0.499820240926922 0.294834577043257 no 2360 0.308600828506634 3241 4227577
SGTC_2470 5664817 21.68 µM -0.500574355191079 0.294551210512647 no 2361 0.308335357221466 3372 2859561
SGTC_2884 9058502 51.95 µM -0.501320645270852 0.29427090778625 no 2362 0.308072738928099 3379 6471554
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.502115733180392 0.293972412471344 no 2363 0.307793056838743 3342 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.50299039794492 0.293644203883867 no 2364 0.307485511555861 3348 97141
SGTC_1844 rapamycin 4 nM -0.503184268734719 0.29357147891795 no 2365 0.307417361979739 3312 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2101 5377231 179.231 µM -0.504939190398255 0.292913551050833 no 2366 0.306800773546578 3373 2844213
SGTC_1018 4259-0013 28.1 µM -0.504970385167121 0.292901862187087 no 2367 0.306789818259104 3368 6801262
SGTC_1781 st038725 66.3 µM -0.505448401394957 0.292722773771415 no 2368 0.306621965380097 3267 4270275 YIL048W NEO1
SGTC_1082 camptothecin 424.86 nM -0.506331756782298 0.292391959235286 no 2369 0.30631188651975 3090 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1922 5578187 25 µM -0.507143926382918 0.292087957078492 no 2370 0.306026917915854 3455 1350412
SGTC_1966 st070145 16.1 µM -0.508988152883658 0.291398193909189 no 2371 0.305380264133417 3254 3748532
SGTC_1318 1280-3875 124 µM -0.510713645000252 0.290753527830372 no 2372 0.304775792357396 3353 373245
SGTC_1090 efavirenz 20.7 µM -0.51330176112229 0.289787826638175 no 2373 0.303870126125327 3354 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1579 chlormadinone acetate 49.4 µM -0.51349013233859 0.28971759866285 no 2374 0.303804255780514 3409 45114258 A steroidal progestin.
SGTC_662 k832-1615 104 µM -0.513894661216987 0.289566810454167 no 2375 0.303662820157956 3361 5878478
SGTC_2505 galangin 7.89 µM -0.514147459402685 0.289472598599899 no 2376 0.30357444913467 3266 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_264 promethazine 12.5 mM -0.515079454586486 0.289125390661437 no 2377 0.303248749502736 3457 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1045 1348-1485 165 µM -0.51629699631799 0.288672099713788 no 2378 0.30282349688829 3358 6810614
SGTC_2853 9015042 58.44 µM -0.516455959914523 0.288612942256938 no 2379 0.302767995149166 3231 6457456
SGTC_1667 st014849 34.6 µM -0.516502847470923 0.288595494392943 no 2380 0.302751625347137 3377 5348460
SGTC_1254 0550-0035 264 µM -0.516581981823812 0.288566047932398 no 2381 0.302723998154974 3394 15121435
SGTC_1797 st048695 56.8 µM -0.517150249013767 0.288354633225646 no 2382 0.302525639282123 3384 592262 YIL048W NEO1
SGTC_3079 9117512 49.47 µM -0.517542463494916 0.288208758718593 no 2383 0.302388767215143 3394 7185044
SGTC_3196 9111891 49.47 µM -0.518058056980486 0.288017049408248 no 2384 0.302208881534737 3384 18891510
SGTC_1081 sertraline 6 µM -0.518292390181289 0.287929938928122 no 2385 0.302127140779179 3424 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3204 9114183 49.47 µM -0.519099268502972 0.287630087055767 no 2386 0.30184575921058 3286 17027248
SGTC_3113 9123498 49.47 µM -0.519306217518766 0.287553204515064 no 2387 0.301773609145752 3408 8897275
SGTC_2032 5185112 25.99 µM -0.522922272372283 0.286211393612912 no 2388 0.300514172324402 3320 5718189
SGTC_1910 st062352 60.4 µM -0.523461304852895 0.286011629572299 no 2389 0.300326636017376 3308 2245730
SGTC_2116 5511452 16.8835 µM -0.523912036179527 0.285844640596244 no 2390 0.300169861429117 3414 870744
SGTC_1190 1486-1332 13 µM -0.524324311184742 0.285691939699884 no 2391 0.300026495236189 3370 4150046
SGTC_2036 5160441 105 µM -0.52497420901799 0.285451305469842 no 2392 0.299800560043102 3343 134534 YIL048W NEO1
SGTC_32 0928-0142 34.1 µM -0.526031194935765 0.285060147130021 no 2393 0.299433266434677 3397 2244242
SGTC_1712 st032288 53.4 µM -0.527295908412228 0.284592451230732 no 2394 0.298994057582601 3429 2883011
SGTC_562 3772-2733 112 µM -0.527549297637855 0.284498791001375 no 2395 0.298906095933702 3420 2876874 YIL048W NEO1
SGTC_1880 MG-132 525 µM -0.527900631905086 0.284368951723204 no 2396 0.298784153053205 3404 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1094 duloxetine 25.4 µM -0.528077608240817 0.284303558980861 no 2397 0.298722735772664 3320 60834 A selective serotonin reuptake inhibitor.
SGTC_1409 3909-8004 61.9 µM -0.528136142182275 0.284281932275885 no 2398 0.298702423610811 3362 2119279
SGTC_1442 4112-3290 3 µM -0.528911542199641 0.28399551721725 no 2399 0.298433407365171 3357 704353
SGTC_3089 9117425 49.47 µM -0.52968403991272 0.283710311568914 no 2400 0.298165507728205 3375 9401657
SGTC_2314 7727897 200 µM -0.529901015684248 0.283630228938626 no 2401 0.298090280962128 3304 900724
SGTC_387 norethindrone acetate 66.7 µM -0.530384886089416 0.283451678356835 no 2402 0.297922551422575 3346 541197
SGTC_646 4092-0839 27.3 µM -0.530850597714928 0.283279879353413 no 2403 0.297761157116077 3472 877796
SGTC_1876 myriocin 605 nM -0.531738100537973 0.282952621737275 no 2404 0.297453699789341 3461 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_911 3456-4043 236 µM -0.532240799468285 0.282767337193495 no 2405 0.297279614296868 3393 914281
SGTC_3164 9100705 49.47 µM -0.53266690400369 0.282610329434554 no 2406 0.29713209004028 3462 17174235
SGTC_564 3555-0129 330 µM -0.533971665869815 0.282129821485641 no 2407 0.296680568756801 3380 563260
SGTC_273 hydroxyurea 18.1 mM -0.534235040158772 0.282032875702268 no 2408 0.296589464508071 3398 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3035 9091303 49.47 µM -0.535639747470079 0.281516086307188 no 2409 0.29610377641155 3420 25237002
SGTC_508 roscovitine 141 µM -0.536114496326777 0.281341530364112 no 2410 0.295939710990572 3404 160355 A CDKinase inhibitor.
SGTC_806 3966-4455 5.86 µM -0.537035150218362 0.281003172756466 no 2411 0.295621667117003 3325 714982
SGTC_880 0833-0487 87.2 µM -0.537250203029765 0.280924165146034 no 2412 0.295547398834951 3402 76075
SGTC_1091 telmisartan 47.6 µM -0.537434687158874 0.280856396629779 no 2413 0.295483694255377 3448 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2732 terfenadine 20 µM -0.538072847959345 0.280622035213511 no 2414 0.295263378407834 3393 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.53977201159439 0.279998487478894 no 2415 0.294677135560852 3383 6708561
SGTC_2710 st078562 53.7235 µM -0.540500246816959 0.279731450363686 no 2416 0.294426045411343 3365 17250908
SGTC_2702 st077768 96.8 µM -0.540947746224464 0.279567417796191 no 2417 0.294271799916672 3383 6484119
SGTC_1219 1469-0211 33.1 µM -0.542237701728825 0.279094841307887 no 2418 0.293827383018166 3420 6822282
SGTC_1469 k284-2957 126 µM -0.543144506351898 0.278762865189947 no 2419 0.293515155657573 3396 23884841
SGTC_1931 st074438 57.1 µM -0.543433644154941 0.278657053880084 no 2420 0.293415633196681 3409 2787313
SGTC_3268 9137683 49.47 µM -0.544096077325202 0.278414707165419 no 2421 0.293187679842813 3356 1953228
SGTC_1818 st052136 56.3 µM -0.544386707927783 0.278308414341397 no 2422 0.293087695343066 3420 674169
SGTC_1479 0549-0158 134 µM -0.544421277508253 0.278295772466542 no 2423 0.293075803559187 3413 5440202
SGTC_575 k072-0246 11.9 µM -0.545798216973293 0.277792462260218 no 2424 0.292602324526886 3426 6796779
SGTC_3205 9113483 49.47 µM -0.546143097752109 0.277666468248244 no 2425 0.292483788341884 3464 17018033
SGTC_3231 9132313 49.47 µM -0.547490929464211 0.277174337788446 no 2426 0.292020750199537 3398 4905967
SGTC_3097 9117246 49.47 µM -0.548110062736885 0.276948418312065 no 2427 0.291808165750521 3482 16423892
SGTC_719 2810-4230 27.3 µM -0.548252645448772 0.276896403174701 no 2428 0.291759219031806 3388 721079
SGTC_516 3992-2719 87.3 µM -0.548324203773633 0.276870300016983 no 2429 0.291734655467533 3272 5350887 YDR037W KRS1
SGTC_181 1447-1644 8.07 µM -0.549541608238111 0.276426398053419 no 2430 0.291316909239045 3419 534600
SGTC_2652 actinonin 100 µM -0.549663168456901 0.276382092746629 no 2431 0.291275211794642 3393 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2991 9074669 71.4286 µM -0.551385428702376 0.275754751480863 no 2432 0.290684743653203 3476 17333109
SGTC_2864 9034755 47.6 µM -0.551691639215681 0.275643286203358 no 2433 0.290579819587552 3463 4930451
SGTC_272 doxorubicin 8.13 µM -0.552532073870979 0.275337469105833 no 2434 0.29029193291631 3434 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_336 4111-0029 111 µM -0.552961730954764 0.275181190149159 no 2435 0.290144807660641 3388 3131175
SGTC_3050 9093513 49.47 µM -0.553487679786345 0.2749899465156 no 2436 0.289964757298554 3453 25236664
SGTC_2664 lyso-paf C-16 73.48 µM -0.555168935128827 0.274379054018354 no 2437 0.289389557492047 3395 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2017 5132927 60.65 µM -0.555180335904829 0.274374913777452 no 2438 0.289385658829911 3351 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3088 9117578 49.47 µM -0.555310611253669 0.27432760591318 no 2439 0.289341111020695 3486 678341
SGTC_456 gingerol 170 µM -0.555439760637114 0.274280710904493 no 2440 0.289296951417633 3522 442793 A herb.
SGTC_274 sirtinol 40.1 µM -0.555821032106747 0.274142291768843 no 2441 0.289166603060857 3418 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1337 1486-1011 40.3 µM -0.555834574596205 0.27413737585499 no 2442 0.289161973688479 3465 X1337
SGTC_2811 7967822 32.47 µM -0.556515944690627 0.273890095233667 no 2443 0.288929098739566 3455 2232244
SGTC_218 alverine citrate 93.75 µM -0.557165689124077 0.273654394855759 no 2444 0.288707114871417 3478 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2657 nystatin 74.44 µM -0.558047249636717 0.273334761732398 no 2445 0.288406059982308 3457 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1309 pyrazolanthrone 13.4 µM -0.558246738461673 0.27326245743513 no 2446 0.288337954640435 3464 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2265 7929201 200 µM -0.559549439543212 0.272790529294549 no 2447 0.287893399977262 3372 1265108
SGTC_898 1000-0849 28.3 µM -0.561943150567139 0.271924417558351 no 2448 0.287077376382435 3435 6751807
SGTC_2473 5854593 8.94 µM -0.563407837462918 0.27139512821234 no 2449 0.286578600767317 3387 2872951
SGTC_3311 9131146 2.8755 µM -0.563593953999023 0.271327908635072 no 2450 0.286515251214249 3408 4900406 YPR165W RHO1
SGTC_1213 1315-0166 115 µM -0.56367360958686 0.271299142018627 no 2451 0.286488140415254 3410 768401
SGTC_3138 9097216 49.47 µM -0.565253415569564 0.27072892912859 no 2452 0.285950704680209 3479 25237486
SGTC_3073 9114972 49.47 µM -0.565475960594531 0.270648652158443 no 2453 0.285875035398317 3424 41905075
SGTC_2457 5731572 11.68 µM -0.565586291724698 0.270608857659295 no 2454 0.285837524374533 3476 2865357
SGTC_841 0251-0215 91.2 µM -0.566071268822286 0.27043396960982 no 2455 0.285672666782245 3440 3888614
SGTC_2312 7706453 155.7 µM -0.566587091838753 0.270248020192184 no 2456 0.285497373441346 3413 976098
SGTC_3156 9099931 49.47 µM -0.566939434437581 0.270121040710981 no 2457 0.285377665475419 3402 18111053
SGTC_964 1287-0107 19.4 µM -0.567221426038197 0.270019436278674 no 2458 0.285281876400035 3501 51516812 YPR165W RHO1
SGTC_351 caspofungin 25 nM -0.568873085998216 0.269424710749735 no 2459 0.284721135668357 3458 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2748 diazoxide 86.69 µM -0.570183671170616 0.268953266273124 no 2460 0.284276564947482 3408 3019 A potassium channel activatior.
SGTC_697 0508-1955 564 µM -0.570251269635368 0.26892896094934 no 2461 0.284253643506569 3495 6243113
SGTC_753 1322-0200 289 µM -0.570469381095014 0.268850545539864 no 2462 0.28417969180268 3516 5403907
SGTC_1754 st042065 16.137 µM -0.571809804317043 0.26836888897768 no 2463 0.283725417194241 3465 1126236 YIL048W NEO1
SGTC_2676 harmalol 100 µM -0.573042441285553 0.267926346796867 no 2464 0.283307978947406 3493 5459187 A monoamine oxidase inhibitor
SGTC_2926 9010726 65.15 µM -0.573629969671603 0.267715541356084 no 2465 0.2831091134276 3467 2994293
SGTC_2148 5546263 113.568 µM -0.574151077359209 0.267528637660122 no 2466 0.282932785937153 3404 792097
SGTC_857 0438-0306 1.35 µM -0.574275366770248 0.267484068973222 no 2467 0.282890737851483 3510 4686136
SGTC_2612 dictamnine 15.46 µM -0.577284796938485 0.266406067727213 no 2468 0.281873541048942 3417 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2569 tetrandrine 100 µM -0.580634721729058 0.265208689306979 no 2469 0.280743332864822 3389 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_914 3820-6779 408 µM -0.581143400548093 0.265027109259791 no 2470 0.280571905058687 3437 2893481
SGTC_1793 st048256 72.231 µM -0.5822701281049 0.264625133057284 no 2471 0.280192371586076 3456 672022
SGTC_728 3030-5151 22.5 µM -0.583103021992409 0.264328185713448 no 2472 0.279911974749452 3506 3125388
SGTC_661 1304-0007 33.6 µM -0.583231665899084 0.264282336097142 no 2473 0.279868678432834 3463 3117130
SGTC_3031 9088762 49.47 µM -0.583325610875194 0.264248855988597 no 2474 0.279837062419861 3429 205253
SGTC_2289 7946404 165.07 µM -0.583609391821924 0.264147735258833 no 2475 0.279741569994549 3473 1246120 YPR165W RHO1
SGTC_3036 9090181 49.47 µM -0.585784500068912 0.263373325873379 no 2476 0.279010170518919 3503 25236586
SGTC_1183 1254-0324 198 µM -0.586199788849761 0.263225601437241 no 2477 0.278870631788367 3520 5799357
SGTC_119 0121-0043 24.815 µM -0.586615467302596 0.263077780783401 no 2478 0.278730996139738 3564 1092378
SGTC_1121 fusaric acid 630.51 nM -0.588302126515415 0.262478418456622 no 2479 0.278164759249596 3418 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2325 6158266 200 µM -0.589146371238651 0.262178674840355 no 2480 0.277881544416899 3462 3623240
SGTC_2987 9018338 71.43 µM -0.589196121812926 0.262161016695325 no 2481 0.277864859216971 3543 5055682
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.59206125249895 0.261145115007598 no 2482 0.276904786178025 3485 688788
SGTC_137 0438-0332 85.389 µM -0.593845604456805 0.260513453639874 no 2483 0.276307691866852 3533 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_370 0180-0345 38.7 µM -0.594395247721598 0.260319038298001 no 2484 0.276123893122808 3438 3989527
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.594423340056741 0.260309103714105 no 2485 0.276114500758694 3417 803109
SGTC_1159 4092-0538 61.2 µM -0.596269139474696 0.25965678284609 no 2486 0.275497721894959 3544 717301
SGTC_453 enantio-paf c16 10 µM -0.596751196710071 0.259486558881483 no 2487 0.27533675284297 3519 13871343 A lipid and platelet activating factor
SGTC_1220 1838-0075 193 µM -0.597952424254682 0.259062632510321 no 2488 0.274935839179067 3481 5529645
SGTC_1822 st052468 42 µM -0.600582495755619 0.258135703478503 no 2489 0.274059049759306 3445 2873678
SGTC_374 0880-0231 82.3 µM -0.601457891315507 0.257827565390461 no 2490 0.273767525080822 3515 6833587
SGTC_668 1682-0499 62.6 µM -0.601531692533811 0.25780159618605 no 2491 0.273742954773022 3492 682214
SGTC_574 1315-0397 40 µM -0.602004598795197 0.257635221953284 no 2492 0.273585538109105 3566 6794277
SGTC_757 1066-0008 322 µM -0.602065005497779 0.257613974149459 no 2493 0.273565433711371 3526 6842497
SGTC_2939 9044578 71.43 µM -0.602208216600089 0.257563603882118 no 2494 0.273517773495612 3496 2653634
SGTC_2347 9049783 174.81 µM -0.602339100151794 0.257517573939786 no 2495 0.273474219445585 3529 6467988 YPL169C MEX67
SGTC_2653 dihydrofissinolide 100 µM -0.602585924705003 0.257430780772504 no 2496 0.27339209311332 3528 6857746
SGTC_2056 5235370 200 µM -0.603100102065139 0.257250024720616 no 2497 0.273221049277247 3465 5511916
SGTC_177 1327-0068 8.361 µM -0.60378865605846 0.257008070952754 no 2498 0.27299208119118 3519 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1385 3091-4834 14.1 µM -0.603915244188353 0.256963601524393 no 2499 0.27294999660195 3502 4072814
SGTC_813 k007-0158 173 µM -0.607060048348551 0.255860142553239 no 2500 0.271905531198462 3513 6523916
SGTC_189 3970-0742 2.116 µM -0.609029621112796 0.255170314127935 no 2501 0.27125240260854 3567 2891807
SGTC_1396 3511-0007 98.6 µM -0.609403696192551 0.255039407062801 no 2502 0.271128444271217 3502 X1396
SGTC_740 k014-0057 261 µM -0.610697934176257 0.254586761439961 no 2503 0.270699786958099 3500 4012779
SGTC_2253 7938677 135.83 µM -0.612255438271252 0.254042599797498 no 2504 0.270184383805767 3584 2301972
SGTC_1197 1601-0112 267 µM -0.61285134569752 0.253834562841591 no 2505 0.269987318345634 3494 7350313
SGTC_2028 5153890 36.43 µM -0.614644468587201 0.253209106395657 no 2506 0.269394770189211 3517 2830968 YPR165W RHO1
SGTC_2499 avocadenofuran 51.48 µM -0.615068512112509 0.253061315002158 no 2507 0.269254737860647 3428 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_534 k292-0788 63.4 µM -0.615081168565496 0.253056904560985 no 2508 0.269250558868352 3589 4146317
SGTC_2531 methyl deoxycholate 70.07 µM -0.615935136321176 0.252759412686501 no 2509 0.268968665255231 3489 16667744 Haematoxylin.
SGTC_1697 st025554 27.742 µM -0.617108803341686 0.252350849657604 no 2510 0.268581481231493 3533 1269519
SGTC_526 4469-0568 170 µM -0.617691745172684 0.252148052340564 no 2511 0.268389277230186 3557 2901964
SGTC_1771 st048882 4.1505 µM -0.618448513872295 0.251884911371186 no 2512 0.26813986332966 3433 4580403
SGTC_1294 1000-1494 117 µM -0.619211585657464 0.251619725554786 no 2513 0.267888490240571 3512 712797 YDL207W GLE1
SGTC_3291 9121177 71.43 µM -0.619521756140828 0.251511976015754 no 2514 0.267786347012974 3486 17015612
SGTC_3115 9123671 49.47 µM -0.621502469622279 0.250824475057114 no 2515 0.26713453504471 3626 3286988
SGTC_289 k017-0060 526 µM -0.621590236353395 0.250794034468457 no 2516 0.267105671365086 3517 5512909
SGTC_1193 1488-0126 41.5 µM -0.622665532551264 0.250421242774295 no 2517 0.266752168595356 3573 1384710
SGTC_1655 st012546 55.1 µM -0.623088672245052 0.250274626120302 no 2518 0.266613126617046 3521 720985 YLR208W SEC13
SGTC_2564 betulinic acid 100 µM -0.625286806517529 0.249513712032757 no 2519 0.265891418780488 3607 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1681 tripelennamine 100 µM -0.625305111212715 0.24950738077832 no 2520 0.265885413005267 3561 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2581 avocatin a 64 µM -0.625965894203381 0.249278885375059 no 2521 0.265668655975886 3522 6710728 A skin care supplement.
SGTC_403 arphamenine a 50 µM -0.62637274444879 0.24913825398633 no 2522 0.265535241235543 3530 5487158 An arginine aminopeptidase inhibitor.
SGTC_1789 tunicamycin 25 nM -0.628063301759865 0.248554350163239 no 2523 0.264981236245653 3569 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1102 cgs 12066b 26.1 µM -0.629669952951059 0.24800010321717 no 2524 0.264455272613177 3519 6438352 A 5-HT1B full agonist.
SGTC_793 0488-0545 106 µM -0.632109842636294 0.247159676508608 no 2525 0.263657552028033 3510 292548
SGTC_41 0478-0632 82.643 µM -0.63395521342006 0.246525046587848 no 2526 0.263055025439891 3597 3750424
SGTC_257 daunorubicin 18.5 µM -0.633960290560863 0.246523301745216 no 2527 0.263053368688784 3577 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2873 9040596 71.43 µM -0.6349530531241 0.246182249791303 no 2528 0.262729517106019 3581 6463863
SGTC_2791 5663188 71.43 µM -0.635916280372348 0.245851586344332 no 2529 0.262415495372249 3555 54690634
SGTC_430 0958-0115 16.4 µM -0.637627578329824 0.245264708380475 no 2530 0.261858069488651 3520 6833180
SGTC_1622 st003707 19.4 µM -0.637660841481324 0.24525330847627 no 2531 0.261847240608857 3586 10140899
SGTC_937 3122-0005 46.7 µM -0.638919063285962 0.244822301590353 no 2532 0.261437792927424 3577 759535
SGTC_1747 st037496 66.6 µM -0.639065499569822 0.244772165990672 no 2533 0.261390161332032 3568 723305
SGTC_2100 5377183 190 µM -0.639381947551448 0.244663842122876 no 2534 0.261287244948005 3600 2844202
SGTC_1898 st060199 18.6 µM -0.639805014985395 0.244519061497015 no 2535 0.261149685917684 3586 688866
SGTC_590 k048-0076 22.4 µM -0.639851215316205 0.244503253780519 no 2536 0.261134666281608 3590 6832814
SGTC_1625 st003711 30.1 µM -0.640197929593108 0.244384641010197 no 2537 0.261021964326542 3635 24207034 YER133W GLC7
SGTC_998 3996-0085 177 µM -0.641369570878799 0.243984045935195 no 2538 0.260641299076976 3597 715391
SGTC_1203 3992-3522 103 µM -0.641980445986181 0.243775322628068 no 2539 0.260442939668251 3731 5322312
SGTC_504 lovastatin 124 µM -0.642658376027551 0.243543800925742 no 2540 0.260222897667318 3536 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1172 0370-0043 85 µM -0.644149627947183 0.243034937724912 no 2541 0.259739205678072 3616 376585
SGTC_1557 sumaresinolic acid 42.3 µM -0.645173595610171 0.242685860245177 no 2542 0.259407347610432 3546 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2092 5303694 80.6725 µM -0.645292438285033 0.242645363563321 no 2543 0.25936884603342 3568 1963699
SGTC_199 4063-0024 41.6 µM -0.645872888900867 0.242447622521107 no 2544 0.259180839315354 3618 306215
SGTC_2691 st077356 60.2 µM -0.647801660798783 0.241791178794422 no 2545 0.258556620543021 3625 2839272
SGTC_2449 5812982 45.77 µM -0.647903098299913 0.241756681983515 no 2546 0.258523813344116 3568 776185
SGTC_190 3970-0790 3.722 µM -0.648303711094435 0.241620467909478 no 2547 0.258394267113261 3573 2832352
SGTC_3030 9087619 49.47 µM -0.648525150760191 0.241545193144661 no 2548 0.258322674565178 3559 25236973
SGTC_224 benfluorex 43.875 µM -0.650806391242333 0.240770464904973 no 2549 0.257585736995724 3603 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2108 5365811 200 µM -0.650965878208111 0.240716352421928 no 2550 0.257534256794802 3607 780283
SGTC_967 1306-0166 352 µM -0.650990262092245 0.240708079774254 no 2551 0.257526386483079 3589 4437607
SGTC_2962 9082311 13.18 µM -0.651514766798339 0.240530170092926 no 2552 0.257357123953047 3572 16459453
SGTC_750 4073-0104 132 µM -0.654522702776434 0.239511275542492 no 2553 0.256387552747581 3483 22330957
SGTC_1391 3442-0225 151 µM -0.656450785752642 0.238859406919424 no 2554 0.255767061527872 3569 5227075
SGTC_2953 9074162 66.49 µM -0.656905469891561 0.238705823557392 no 2555 0.255620850443956 3567 16451992
SGTC_3180 9109287 49.47 µM -0.657257312121056 0.238587015262865 no 2556 0.255507739815789 3596 18891271
SGTC_2040 5100729 123 µM -0.657662056202344 0.238450383379977 no 2557 0.255377654590593 3613 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1124 fisetin 1.16336 µM -0.658138916772151 0.238289461688552 no 2558 0.255224435466863 3582 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1682 st012968 530 nM -0.658405812185389 0.238199420952181 no 2559 0.255138700814989 3554 24207270
SGTC_1865 st057639 52.2 µM -0.659516789487045 0.237824818273824 no 2560 0.254781984154494 3609 688818
SGTC_1238 0333-0287 48.8 µM -0.660495773987172 0.237494989297555 no 2561 0.254467864773361 3609 7226
SGTC_3290 9121031 71.43 µM -0.66139687588364 0.237191621743666 no 2562 0.254178914453606 3572 17014854
SGTC_3275 9138069 49.47 µM -0.661997889583382 0.236989401144895 no 2563 0.25398628710728 3624 17617007
SGTC_1280 0880-0253 10.1 µM -0.662205960978029 0.23691941430958 no 2564 0.253919617229038 3589 6836607
SGTC_61 0978-8327 98.565 µM -0.663420051321782 0.236511269881434 no 2565 0.253530783710579 3636 6150059 YHR072W ERG7
SGTC_3211 9128781 49.47 µM -0.665964483692872 0.235657156946655 no 2566 0.252716900989611 3592 17194361
SGTC_3330 9141424 71.43 µM -0.666598312697496 0.235444658737901 no 2567 0.25251437358355 3624 27261020
SGTC_843 0310-0051 143 µM -0.666869277815299 0.235353846950883 no 2568 0.252427818191091 3631 2065037
SGTC_3110 9122132 49.47 µM -0.66739660809573 0.235177171873853 no 2569 0.252259415960267 3701 918317
SGTC_2793 7325131 81.82 µM -0.66762806852953 0.23509964723415 no 2570 0.252185518086833 3601 4176441
SGTC_2099 5377090 177.372 µM -0.668114009712099 0.234936933537916 no 2571 0.252030409847428 3603 2243829
SGTC_3313 9133968 57.047 µM -0.66895714481659 0.234654763895663 no 2572 0.251761407864019 3608 1494643
SGTC_3310 9130229 44.1445 µM -0.669479695000421 0.234479977613954 no 2573 0.251594764524249 3629 7761258
SGTC_1486 3970-0793 4.53 µM -0.671280096754437 0.233878318451595 no 2574 0.251021055749968 3654 2844330
SGTC_1986 st071812 45 µM -0.671605899092677 0.233769533142023 no 2575 0.250917310903249 3607 11838594
SGTC_258 haloperidol 50.781 µM -0.671718614824335 0.233731903921565 no 2576 0.250881424252787 3606 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_730 1436-0052 41.2 µM -0.671866236798183 0.233682626617678 no 2577 0.250834428195533 3651 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_604 1000-0114 314 µM -0.672822998877271 0.233363392047624 no 2578 0.25052995210834 3662 1572745
SGTC_1432 4049-0298 68.4 µM -0.672964869216077 0.233316076001156 no 2579 0.250484820543984 3639 741646
SGTC_2476 5806916 10.51 µM -0.676782023651839 0.232044993900625 no 2580 0.249272132663534 3564 2870194
SGTC_2868 9035608 32.47 µM -0.677090884697476 0.231942314487619 no 2581 0.249174145991633 3635 6462614
SGTC_3143 9086658 49.47 µM -0.677270563872469 0.231882592627586 no 2582 0.249117151906159 3689 25236626
SGTC_788 1182-0090 188 µM -0.677301888491905 0.231872181810659 no 2583 0.24910721647272 3713 5715185
SGTC_1010 4112-3296 15.2 µM -0.67760604711717 0.231771107455709 no 2584 0.2490107554628 3671 704384
SGTC_926 2268-1401 59.4 µM -0.678480318123157 0.231480716899054 no 2585 0.248733599449116 3638 2931578
SGTC_1775 st081588 35.1725 µM -0.678619288206572 0.231434576448678 no 2586 0.248689559144378 3675 1426443 YGL099W LSG1
SGTC_3182 9108849 49.47 µM -0.679225163060963 0.231233475537429 no 2587 0.248497602944924 3659 17133045
SGTC_876 0720-0963 56.8 µM -0.679870254711439 0.23101946505477 no 2588 0.248293308703697 3657 765861
SGTC_393 acivicin 6.25 µM -0.680183172774197 0.230915693679431 no 2589 0.248194242864167 3562 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_973 1325-0077 65.9 µM -0.681582946998605 0.230451812643123 no 2590 0.247751350492712 3679 2835149
SGTC_292 k038-0015 474 µM -0.681947394997232 0.230331121180859 no 2591 0.247636107432387 3639 46368540
SGTC_2800 7887935 81.82 µM -0.682436872856478 0.230169080160574 no 2592 0.247481373413263 3631 2961002
SGTC_1079 idarubicin 2.36 µM -0.683534364712622 0.229805988777128 no 2593 0.247134621531223 3624 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1488 4013-0813 75.9 µM -0.683718125855939 0.229745225073312 no 2594 0.247076587718156 3627 2910057
SGTC_2885 9057732 51.95 µM -0.683746617343003 0.229735804691021 no 2595 0.247067590442453 3662 6471414
SGTC_1146 3579-1023 7 µM -0.683755782333173 0.229732774438484 no 2596 0.247064696283869 3687 X1146
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.684101078062043 0.229618624421522 no 2597 0.246955670582117 3678 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1943 st076331 65.2 µM -0.68453242486528 0.229476071751171 no 2598 0.246819510785798 3700 24208415
SGTC_96 0929-0093 37.281 µM -0.684663185932037 0.229432867274484 no 2599 0.246778242424802 3618 6991579
SGTC_93 0109-0045 59.227 µM -0.685331289029793 0.229212191964579 no 2600 0.246567445896193 3715 88733
SGTC_2810 7959871 45.46 µM -0.685677345863012 0.229097935756984 no 2601 0.246458297717241 3655 2974535
SGTC_2322 7413319 38.22 µM -0.685919201180626 0.229018102318667 no 2602 0.246382030627678 3693 1840400
SGTC_1240 0356-0016 42.1 µM -0.686348559869662 0.228876414801043 no 2603 0.246246667055421 3639 4305613
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.687449208993988 0.22851342756852 no 2604 0.245899848482302 3664 6708739 YPR165W RHO1
SGTC_3320 9137005 35.139 µM -0.687807432775049 0.228395357386503 no 2605 0.245787027426335 3639 4908713
SGTC_2224 6650123 117.647 µM -0.690673758751822 0.227451854838056 no 2606 0.244885291846029 3638 2908370
SGTC_2936 9038235 15.59 µM -0.693361530479785 0.226569124647956 no 2607 0.244041348914944 3661 4749415
SGTC_18 0111-0177 500 nM -0.693540892549654 0.226510286656784 no 2608 0.243985086277907 3744 721752
SGTC_2006 4011487 200 µM -0.693576052301928 0.2264987538517 no 2609 0.243974058119947 3697 45595294
SGTC_245 methotrexate 289.6 µM -0.695254111858611 0.225948716570629 no 2610 0.243448033176829 3654 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_682 0kpi-0099 17 µM -0.695778638485508 0.225776941371128 no 2611 0.243283734472401 3674 1714895 YML126C ERG13
SGTC_2880 9042983 58.44 µM -0.697733903848025 0.22513727035528 no 2612 0.242671810569792 3672 6464714
SGTC_2441 5730946 39.09 µM -0.697765311511813 0.225127003628179 no 2613 0.242661987966953 3702 1774275
SGTC_2320 7373003 200 µM -0.698389548241709 0.224923004384365 no 2614 0.242466805454782 3679 5415828
SGTC_1953 st076800 12.1 µM -0.699099762319499 0.22469103540078 no 2615 0.242244843531148 3671 297591
SGTC_831 k061-1017 217 µM -0.699646156387421 0.224512665432979 no 2616 0.242074154965268 3723 1240153
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.700491017547815 0.224237019316019 no 2617 0.241810356414912 3689 66535 A nucleotide analog.
SGTC_3003 9075612 71.4286 µM -0.700516916843076 0.224228572396093 no 2618 0.241802272111582 3675 6501993
SGTC_1958 st076513 41.9 µM -0.700821714213747 0.224129177900725 no 2619 0.24170714253585 3652 732122 YGL099W LSG1
SGTC_2593 nobiletin 86.24 µM -0.701420284385189 0.223934056867023 no 2620 0.241520383371614 3646 72344 An anti-infammatory.
SGTC_3184 9108758 49.47 µM -0.703346481287011 0.223306813505767 no 2621 0.240919925189343 3689 902885
SGTC_1004 4084-0029 199 µM -0.7039635108267 0.223106096745176 no 2622 0.240727748889104 3688 716894 YLR208W SEC13
SGTC_349 k015-0014 24 µM -0.704726794512767 0.222857946403192 no 2623 0.240490136632023 3667 2196908
SGTC_2348 9022543 33.42 µM -0.704792106549651 0.222836720182769 no 2624 0.240469810753536 3691 3162678 YDL140C RPO21
SGTC_645 0845-0943 5.41 µM -0.70623955403415 0.222366599736477 no 2625 0.240019588184565 3685 1885106
SGTC_1731 st035964 63 µM -0.70720850107047 0.222052209153681 no 2626 0.239718458212036 3679 6739575
SGTC_1816 st051957 91.6 µM -0.70764126157085 0.221911875006239 no 2627 0.239584031260585 3686 674121
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.71100915990398 0.220821476331682 no 2628 0.238539279806153 3648 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2916 7875993 68.79 µM -0.712523228244451 0.220332279369577 no 2629 0.238070416422037 3664 1299250
SGTC_3033 9090887 49.47 µM -0.712544824247329 0.22032530617699 no 2630 0.238063732417141 3714 19325384
SGTC_3017 9080681 49.47 µM -0.713187410607429 0.220117877602681 no 2631 0.237864897756567 3701 16451914
SGTC_3227 9130768 49.47 µM -0.713322985948049 0.220074127838525 no 2632 0.237822958492308 3707 17720899
SGTC_1487 3970-0795 2.82 µM -0.713677415513322 0.219959778027434 no 2633 0.23771333739664 3754 3765103
SGTC_469 w7 172 µM -0.715906559785125 0.219241369908512 no 2634 0.237024523843809 3744 45115570 A P450 inhibitor.
SGTC_2381 9035592 200 µM -0.716935930811551 0.218910080177998 no 2635 0.236706815124599 3695 4749657
SGTC_2389 9091542 195.52 µM -0.717256650521842 0.218806919564599 no 2636 0.236607874938701 3716 3626624 YOL127W RPL25
SGTC_3220 9131269 49.47 µM -0.720270558828855 0.217838852987586 no 2637 0.235679214015973 3751 17722206
SGTC_2734 clemastine 41.6 µM -0.720877736264879 0.217644127137605 no 2638 0.235492370963466 3699 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1032 k061-1018 98.7 µM -0.722098009932141 0.217253081165504 no 2639 0.235117110823691 3815 4005393
SGTC_1857 st056007 79.3 µM -0.723615135016201 0.216767473252079 no 2640 0.234651023484532 3711 619834
SGTC_546 peri-Naphthalide 147 µM -0.724836928944925 0.216376852884988 no 2641 0.234276038773109 3670 223824 A penicillin ester.
SGTC_670 4204-0025 119 µM -0.7279844030451 0.215372451040953 no 2642 0.233311566985444 3748 719039
SGTC_3269 9137823 49.47 µM -0.729956069644151 0.214744645790813 no 2643 0.232708518837061 3669 17682936
SGTC_2733 amorolfine 100 µM -0.730698970539917 0.214508372212525 no 2644 0.232481522254019 3736 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1516 st013856 110 µM -0.731320464560246 0.214310827259856 no 2645 0.23229171670056 3737 5281404 A mutagen and neurotoxin.
SGTC_2181 6316240 54.2555 µM -0.732911343214568 0.21380564097722 no 2646 0.231806252122741 3727 12779990
SGTC_3006 9075424 71.4286 µM -0.733221902212621 0.213707103393824 no 2647 0.231711549469093 3725 7465181
SGTC_2038 4100038 30.985 µM -0.733624331856667 0.213579455435738 no 2648 0.231588863620269 3731 3596803
SGTC_1776 st049249 45.9 µM -0.733703351942942 0.213554396018541 no 2649 0.231564777584906 3763 1822314
SGTC_3279 9140807 49.47 µM -0.734560247768834 0.213282761105771 no 2650 0.231303677694126 3766 45595718
SGTC_1661 st013063 9.66 µM -0.734930898493096 0.213165327732227 no 2651 0.231190789701585 3765 721395
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.736109911151315 0.212792031679158 no 2652 0.230831905799331 3795 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2102 5377816 72.7585 µM -0.736178517167555 0.212770321568465 no 2653 0.230811032150419 3741 1379702
SGTC_2618 avocadyne 43.43 µM -0.736980568248556 0.212516611518214 no 2654 0.230567083186042 3670 3015189
SGTC_3155 9099265 49.47 µM -0.737003587811555 0.212509332429021 no 2655 0.230560083766488 3702 25236499
SGTC_1629 st005085 44.9 µM -0.738689601282023 0.211976588843257 no 2656 0.230047750798164 3742 24207091
SGTC_1656 st012921 11 µM -0.739137514826644 0.211835189341218 no 2657 0.229911749412703 3685 6732821
SGTC_1430 4049-0248 69.1 µM -0.7398771729792 0.211601811345114 no 2658 0.229687263260133 3759 22774488
SGTC_530 4358-1714 28 µM -0.739900650226638 0.211594406235844 no 2659 0.229680139929339 3813 1564641
SGTC_1678 st019265 80.2 µM -0.740435171297767 0.211425850565378 no 2660 0.229517992116336 3739 5367020
SGTC_987 1497-1013 404 µM -0.740561792601107 0.211385933375109 no 2661 0.229479590742575 3729 1676435
SGTC_951 1171-0579 82.7 µM -0.743138053408621 0.210574729719322 no 2662 0.228699051501475 3721 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_140 0062-0056 502.533 µM -0.743787555362324 0.210370505598884 no 2663 0.22850250504319 3727 3758964
SGTC_2561 acetosyringone 100 µM -0.745833560592013 0.209727936904032 no 2664 0.227883981962673 3761 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_780 0109-0199 192 µM -0.746105319377532 0.20964267520738 no 2665 0.227801898126476 3766 610414
SGTC_2485 5633444 17.78 µM -0.748082117955344 0.209023087429821 no 2666 0.227205313670226 3766 5724239
SGTC_139 0099-0334 718.624 µM -0.749307072949003 0.208639691702687 no 2667 0.226836072863805 3780 97690
SGTC_35 0133-0054 64.071 µM -0.750640246484952 0.208222896364747 no 2668 0.226434596490547 3744 99677
SGTC_989 1501-0895 10.3 µM -0.751985126812157 0.207802939269482 no 2669 0.226030001570389 3725 2830112
SGTC_2145 5634607 200 µM -0.752662379565814 0.20759164745075 no 2670 0.225826411097442 3733 308662
SGTC_2342 7990637 118.86 µM -0.755023165439981 0.206856113954935 no 2671 0.225117541387406 3829 2033102 YER133W GLC7
SGTC_1019 4262-0212 3.4 µM -0.755125708792139 0.206824200238489 no 2672 0.225086779440967 3795 4677213
SGTC_1981 st071826 47 µM -0.757553891709253 0.206069349011987 no 2673 0.224359045947465 3776 11838600
SGTC_1291 0993-0025 5.79 µM -0.764306301920024 0.203978828059988 no 2674 0.222342365392111 3812 4353356
SGTC_695 3505-6186 243 µM -0.76473498752488 0.203846536570181 no 2675 0.22221468383233 3776 1819379
SGTC_172 1112-0046 2.638 µM -0.765933554071601 0.203476932878072 no 2676 0.221857919744011 3748 2802135 YIL048W NEO1
SGTC_2471 5466956 24.79 µM -0.766076230335186 0.203432962234569 no 2677 0.221815472673851 3735 724419
SGTC_2054 5233173 129 µM -0.766195100498495 0.203396332596457 no 2678 0.221780111608342 3805 6889
SGTC_163 TUB2.036 7.546 µM -0.766403320369248 0.203332179482587 no 2679 0.221718178876954 3822 15992207 YJR013W GPI14
SGTC_1845 st056753 3.01 µM -0.767940978091199 0.202858796851412 no 2680 0.221261125377452 3750 5375839
SGTC_1449 4112-4002 201 µM -0.768405315201885 0.202715975755956 no 2681 0.221123211792698 3802 2059539
SGTC_1047 2043-3044 82 µM -0.76974680965393 0.202303695750211 no 2682 0.220725048591107 3798 669592
SGTC_1843 st055809 45.5 µM -0.769899505606914 0.202256799684238 no 2683 0.220679753605733 3820 16413835
SGTC_1610 st001799 48.1 µM -0.771218810218483 0.201851884998746 no 2684 0.220288623288441 3716 621897
SGTC_624 k048-0052 28 µM -0.771721110958115 0.201697848909273 no 2685 0.220139812215325 3772 6835531
SGTC_3098 9119039 49.47 µM -0.772788164686701 0.20137085878345 no 2686 0.219823879444728 3778 17161528
SGTC_2152 5568786 200 µM -0.77308449017519 0.201280108596993 no 2687 0.219736189726401 3764 5399883
SGTC_3317 9138495 8.753 µM -0.773285856895611 0.201218453689402 no 2688 0.219676612014945 3757 17020139
SGTC_2216 7189485 200 µM -0.77334162012378 0.201201381983233 no 2689 0.219660115171497 3772 731273
SGTC_2477 5967686 25.23 µM -0.773442335463015 0.201170550555324 no 2690 0.219630321619173 3806 776118
SGTC_2620 irigenin 100 µM -0.773991176633212 0.201002586644632 no 2691 0.219468004532933 3814 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2178 5812956 200 µM -0.7740041412007 0.200998620067029 no 2692 0.219464171159002 3773 5403383
SGTC_1831 st055328 12 µM -0.775206533109555 0.200630946100674 no 2693 0.219108814187497 3761 1103068
SGTC_614 0462-0418 107 µM -0.775467743179635 0.200551125280392 no 2694 0.219031659481377 3637 5188303
SGTC_2481 5478948 45.16 µM -0.775760524354242 0.200461679602048 no 2695 0.218945198060868 3814 77792
SGTC_1490 4089-0339 670 nM -0.775963620418414 0.200399647117671 no 2696 0.218885233149654 3741 742542
SGTC_798 1287-0182 476 µM -0.776759226542913 0.200156752879526 no 2697 0.218650418337218 3806 1649755
SGTC_874 0599-0792 117 µM -0.77693730621339 0.20010241036581 no 2698 0.218597879855359 3796 765305
SGTC_2070 5230947 200 µM -0.777529308882246 0.199921819514422 no 2699 0.218423274765083 3845 2835538
SGTC_2366 9070441 60.58 µM -0.780897344802024 0.198896263915459 no 2700 0.217431436934106 3798 6837235
SGTC_1424 4048-1941 275 µM -0.78247618723234 0.19841660531582 no 2701 0.216967387286904 3876 X1424
SGTC_2051 5263410 176 µM -0.78333991319003 0.198154497551956 no 2702 0.216713765409271 3849 227584
SGTC_446 go6976 132 µM -0.783891876707594 0.197987107284437 no 2703 0.21655177834543 3779 3501 A protein kinase C inhibitor.
SGTC_1480 1070-0044 41.2 µM -0.786360207659474 0.197239598607421 no 2704 0.2158282444519 3810 3124987
SGTC_653 0203-0016 55.2 µM -0.787210500515956 0.196982492046846 no 2705 0.215579325665109 3845 295302
SGTC_2484 5809818 12.04 µM -0.787309745715083 0.196952496093091 no 2706 0.215550283005712 3816 2870548
SGTC_1970 st070122 35.8 µM -0.788317793334672 0.19664797962106 no 2707 0.215255421176172 3814 102928
SGTC_3300 9124615 50.48 µM -0.788891197750289 0.196474889846902 no 2708 0.215087800392055 3849 24824903
SGTC_2942 9052777 62.25 µM -0.789222567098279 0.196374903695319 no 2709 0.214990967213285 3898 6469503
SGTC_947 3447-0010 211 µM -0.790148380107879 0.196095715831489 no 2710 0.214720559150823 3803 748350
SGTC_643 k048-0106 28.4 µM -0.790496904639059 0.19599067729158 no 2711 0.214618814612664 3837 6763920
SGTC_2536 dehydroabietamide 32.04 µM -0.792066676548966 0.195518001684077 no 2712 0.214160899602385 3850 3983547
SGTC_1035 k081-0041 55.2 µM -0.792728297382154 0.195318987920306 no 2713 0.213968069943324 3802 731709
SGTC_1370 2001-0092 44.6 µM -0.794665979074226 0.194736846904351 no 2714 0.21340391362758 3881 790957
SGTC_3241 9133421 49.47 µM -0.796827156173175 0.194088807389387 no 2715 0.212775710603525 3837 17018221
SGTC_725 1497-0963 19 µM -0.798228368268266 0.19366934997455 no 2716 0.212368988933325 3854 3549977
SGTC_50 0929-0078 56.389 µM -0.79949274945915 0.193291328160887 no 2717 0.21200237459336 3724 1377751
SGTC_698 k064-0052 127 µM -0.800022739915079 0.193133006844885 no 2718 0.211848811082008 3880 5088751
SGTC_853 0419-0306 21 µM -0.806903411990693 0.191084771736456 no 2719 0.209861066454556 3853 762713
SGTC_779 1360-0071 233 µM -0.808482029734755 0.19061673497168 no 2720 0.20940657343153 3920 7566
SGTC_1511 0906-3109 28.5 µM -0.809346390084084 0.190360763343683 no 2721 0.209157964747706 3881 2882180
SGTC_634 1611-4317 11.2 µM -0.809629819979561 0.190276874414288 no 2722 0.209076482043461 3845 2843522
SGTC_1478 0453-0656 35.7 µM -0.809726572196008 0.190248243115603 no 2723 0.209048671218925 3864 5258496
SGTC_2107 5363541 170.161 µM -0.812023163945869 0.189569403843365 no 2724 0.208389169999808 3822 244052
SGTC_2292 7671323 168.05 µM -0.81216331539868 0.18952802540665 no 2725 0.20834896314916 3886 937504
SGTC_308 4092-1169 104 µM -0.81231917248073 0.189482016553248 no 2726 0.208304256019286 3798 2268590 YDL196W YDL196W
SGTC_2022 5136654 200 µM -0.81502664565425 0.188683870276006 no 2727 0.20752852903592 3901 1713771
SGTC_990 3985-0011 41.3 µM -0.815177160027422 0.188639560465293 no 2728 0.207485454823734 3870 5399565 YGL099W LSG1
SGTC_115 0527-0192 112.043 µM -0.815335272160799 0.188593020865155 no 2729 0.207440211975674 3890 4233931
SGTC_2902 5787006 60.46 µM -0.816059969563003 0.188379800017178 no 2730 0.207232918748645 3813 591003
SGTC_1477 0139-0234 16 µM -0.816246207095237 0.18832502913897 no 2731 0.207179666957076 3872 620880
SGTC_1653 st012112 65 µM -0.81724462438049 0.188031570618954 no 2732 0.206894322741251 3841 720429
SGTC_1422 4031-0024 15.5 µM -0.818226701557859 0.187743190393789 no 2733 0.206613875521177 3794 782427
SGTC_689 0833-0039 98 µM -0.819078283717724 0.187493350411283 no 2734 0.206370875510126 3835 5374726
SGTC_2016 5121758 140 µM -0.821339746500105 0.186830872976268 no 2735 0.205726386922716 3826 2795203
SGTC_1250 0485-0349 40.2 µM -0.823061286134828 0.186327534126105 no 2736 0.205236571374438 3876 6842794 YDL195W SEC31
SGTC_625 k213-0058 121 µM -0.823220400222756 0.186281055254418 no 2737 0.205191334954119 3925 3655420
SGTC_2986 9022445 71.43 µM -0.823357456672908 0.186241025406592 no 2738 0.205152374309568 3833 6459286
SGTC_2961 9083290 32.55 µM -0.824794710417717 0.185821570210597 no 2739 0.204744075128147 3817 17741490
SGTC_1412 3909-8563 178 µM -0.825410572333726 0.185642013511294 no 2740 0.204569267333604 3941 23767530
SGTC_13 0199-0087 65 µM -0.826944013094239 0.185195401418598 no 2741 0.204134397684585 3904 4589825
SGTC_481 bay k-8644 50 µM -0.827328708242177 0.185083464377493 no 2742 0.204025388146653 3846 2303 A calcium channel antagonist.
SGTC_2446 5162541 200 µM -0.827435454194461 0.185052411322023 no 2743 0.203995146117636 3828 1549321
SGTC_2557 derrustone 83.84 µM -0.828049893184917 0.184873730174815 no 2744 0.203821122306447 3827 629853 An antioxidant.
SGTC_2725 haloperidol 53.21 µM -0.828529180664595 0.184734426057335 no 2745 0.203685438087143 3821 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1608 st001473 40.5 µM -0.831100392039985 0.183988222232687 no 2746 0.202958459146003 3848 7292267
SGTC_1693 xanthone 101.9 µM -0.832426130916478 0.183604207439388 no 2747 0.202584228761807 3925 7020 An insecticide.
SGTC_751 0833-0568 350 µM -0.83255893324727 0.183565767330587 no 2748 0.202546763979748 3949 6954252
SGTC_895 0964-0006 13.7 µM -0.833515746403941 0.183288962613039 no 2749 0.202276960461431 3837 6738897
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.836827198054765 0.182332974984135 no 2750 0.20134485350147 3927 279621
SGTC_3177 9107506 49.47 µM -0.836927138219007 0.182304171634886 no 2751 0.201316762440277 3795 8897194
SGTC_2280 7785178 200 µM -0.837891374474894 0.182026419084551 no 2752 0.201045856773497 3898 2954328
SGTC_424 splitomicin 100 mM -0.838082423229931 0.1819714180612 no 2753 0.200992206900466 3989 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.838495725124505 0.181852468148099 no 2754 0.200876173801739 3913 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_285 1486-1325 46 µM -0.838531707402578 0.181842114608595 no 2755 0.20086607380216 3911 22310230
SGTC_1658 st012944 20 µM -0.839832639335907 0.181468032169468 no 2756 0.200501115084714 3794 24207260
SGTC_1100 amiodarone 5.07 µM -0.840061918578543 0.181402152985058 no 2757 0.200436835221604 3973 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.840593434161667 0.181249489331104 no 2758 0.200287869134309 3871 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_869 0564-0080 44.1 µM -0.841525054270593 0.180982100518119 no 2759 0.200026927631974 3917 6843321
SGTC_70 0141-0289 43.283 µM -0.841776718390171 0.180909911603352 no 2760 0.19995647302016 3914 352408
SGTC_200 k038-0079 37.545 µM -0.842603500166467 0.180672879382805 no 2761 0.199725116440612 3850 3436683
SGTC_1436 4092-1007 8.32 µM -0.843934451831175 0.180291714660866 no 2762 0.199353017545787 3867 2881121
SGTC_722 3534-0461 190 µM -0.844645289891224 0.180088348114998 no 2763 0.199154457131493 3944 658262
SGTC_2911 7942208 15.64 µM -0.845994340938478 0.179702788818227 no 2764 0.198777950618345 3932 1243384
SGTC_65 0798-0905 34.986 µM -0.847008775197868 0.179413205023532 no 2765 0.198495115143701 3942 3602145
SGTC_480 am 92016 50 µM -0.847546708664383 0.179259763841022 no 2766 0.198345231908085 3853 2129 K+ channel blocker.
SGTC_1305 1181-0477 144 µM -0.848115486712968 0.17909761428158 no 2767 0.198186828821827 3948 6252086
SGTC_1581 himbacine 57.9 µM -0.848358499717411 0.179028363288674 no 2768 0.198119173675408 3892 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_262 fenpropimorph 62.5 µM -0.848796403521788 0.178903617143924 no 2769 0.197997295878212 3862 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1410 3909-8106 77.9 µM -0.850661227953285 0.178372995267752 no 2770 0.197478783404123 3939 1039210
SGTC_638 3970-0837 4.09 µM -0.850815664764356 0.178329095929876 no 2771 0.197435879255004 3891 4118451 YLR208W SEC13
SGTC_2807 7945238 51.95 µM -0.85282332010534 0.177759030752931 no 2772 0.196878644831183 3973 17148797
SGTC_961 1252-1571 372 µM -0.854847417932518 0.177185461981665 no 2773 0.19631781172677 3893 6813498
SGTC_1726 st035556 14.5795 µM -0.856269028019811 0.17678331982965 no 2774 0.195924494342178 4043 5919439
SGTC_3126 9127922 49.47 µM -0.857014151877279 0.176572771359018 no 2775 0.195718531760486 3942 45595682
SGTC_1160 4092-0570 10.5 µM -0.85720084866322 0.176520041599114 no 2776 0.195666946774123 3901 4994975
SGTC_1905 st060207 84.5 µM -0.860399660706294 0.17561813183784 no 2777 0.194784386399626 3845 1948547
SGTC_410 α-linolenic acid 100 µM -0.861242080311982 0.175381097013475 no 2778 0.194552364118186 3991 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2728 chlorpromazine 9.18 µM -0.861793060591613 0.17522617535131 no 2779 0.194400702139537 3917 2726 A thorazine and dopamine antagonist.
SGTC_1679 SEC14.276 6.7 µM -0.861801440019039 0.175223819939294 no 2780 0.194398396187085 3933 1005053 YMR079W SEC14
SGTC_1165 k072-0275 30.3 µM -0.865095472003707 0.174299440946326 no 2781 0.193493194883082 3902 6153523 YGL055W OLE1
SGTC_1196 1588-0294 184 µM -0.866500356112783 0.173906143350514 no 2782 0.193107915583038 3936 6144269
SGTC_1380 2291-0730 164 µM -0.866927824907746 0.173786585441445 no 2783 0.192990778359414 3969 2999191
SGTC_3235 9132602 49.47 µM -0.866964126400379 0.173776434757133 no 2784 0.192980832834782 3941 4912240
SGTC_2414 st077232 92.9 µM -0.86843281191601 0.173366074752308 no 2785 0.192578719409778 3897 729801
SGTC_402 epigallocatechin gallate 10 µM -0.869023266445667 0.173201272032342 no 2786 0.192417202492237 3889 65064 An antioxidant.
SGTC_975 1335-0046 28.5 µM -0.871639514813288 0.172472247625882 no 2787 0.191702533360559 3936 16486740
SGTC_3340 9146634 11.102 µM -0.872444244833699 0.172248401652461 no 2788 0.191483036093201 3965 4907387
SGTC_524 r073-0010 27.8 µM -0.8738954210395 0.17184520717206 no 2789 0.191087604286088 3859 2772106
SGTC_2687 chenodiol 100 µM -0.875122922776205 0.171504629268406 no 2790 0.190753512895304 4008 5702181 A cholesterol synthesis inhibitor.
SGTC_1707 st032323 6.317 µM -0.876693815650845 0.171069405068252 no 2791 0.190326483371225 3829 3132057 YMR211W DML1
SGTC_1216 1165-0504 9.65 µM -0.876921076103237 0.171006499897153 no 2792 0.190264753833677 3953 6304004
SGTC_1624 st003710 6.25 µM -0.877515595537388 0.170842008280613 no 2793 0.190103325891511 3966 24207033
SGTC_1499 4480-0877 67.3 µM -0.878011675783303 0.170704830332089 no 2794 0.189968691261618 3863 2861909
SGTC_630 4356-0227 183 µM -0.87940942167938 0.17031869975844 no 2795 0.189589662732173 3919 779312
SGTC_2992 9074591 71.4286 µM -0.880416256344733 0.170040906271277 no 2796 0.189316926580892 3894 17741321
SGTC_3041 9091929 49.47 µM -0.880538091015943 0.170007310849082 no 2797 0.189283939816181 3944 25236887
SGTC_2508 celastrol 40.54 µM -0.882047275331506 0.169591512134047 no 2798 0.188875621260135 3886 122724 Celastrol is a natural product and antioxidant.
SGTC_902 1120-0002 2.07 µM -0.882384331174241 0.169498738330612 no 2799 0.188784503045439 3921 3280475
SGTC_1719 st032227 49.2 µM -0.883467665913618 0.169200773657782 no 2800 0.188491822542296 3950 3125804
SGTC_1648 st011736 69.8 µM -0.884591757216948 0.168891954878806 no 2801 0.188188426977733 3945 2855514
SGTC_2442 5158906 48.48 µM -0.884972868007631 0.168787335517276 no 2802 0.18808563249135 3978 1893835
SGTC_949 1165-0505 146 µM -0.885882331677297 0.168537845420834 no 2803 0.187840468952386 3976 6244267
SGTC_2259 7964009 200 µM -0.885909343212043 0.168530439064984 no 2804 0.187833190489215 4001 313134
SGTC_1765 st044815 90.4 µM -0.886358674121688 0.168407266665177 no 2805 0.18771214041056 3992 645695
SGTC_2683 piperine 63.03 µM -0.88705848887 0.168215545950442 no 2806 0.187523705798152 3925 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_117 lucigenin 22.078 µM -0.887527030241736 0.168087263220255 no 2807 0.187397610034299 3997 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_288 1315-0019 35.1 µM -0.889696274549887 0.167494162849885 no 2808 0.186814497477849 4026 6811474
SGTC_3355 9151058 44.0485 µM -0.890031398395586 0.167402655896414 no 2809 0.186724513395288 3937 17015728
SGTC_2817 7995342 71.43 µM -0.891058409969394 0.167122426810795 no 2810 0.186448917726371 3969 18879975
SGTC_1839 st053978 48 µM -0.893038153885204 0.166583090351676 no 2811 0.185918370410761 3962 3788398
SGTC_1743 st037606 46.3785 µM -0.89343880064703 0.16647408003272 no 2812 0.185811115952834 3929 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_299 1273-0059 1.44 µM -0.898157142894947 0.165193751747039 no 2813 0.184550889033222 3858 2848077
SGTC_2340 7987427 183.45 µM -0.899632486880707 0.164794726686053 no 2814 0.184157931339098 3994 2239331
SGTC_1850 st056238 17 µM -0.899685727623869 0.164780338748782 no 2815 0.184143760416451 3974 5393177
SGTC_778 3456-2434 196 µM -0.900805728960658 0.16447785486635 no 2816 0.183845810493354 3968 5539063
SGTC_611 3453-1652 23.7 µM -0.901479345597707 0.164296101576916 no 2817 0.183666755373905 3957 1560575
SGTC_2543 pimpinellin 60.67 µM -0.904338393805587 0.163526131427146 no 2818 0.182907997101982 3812 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3302 9125395 16.351 µM -0.90544453399331 0.163228866564292 no 2819 0.182614965897613 3922 17599668
SGTC_2835 9006588 71.43 µM -0.905879443561497 0.163112084901474 no 2820 0.182499832922387 4061 2345538
SGTC_2019 4016004 108 µM -0.905958662934115 0.163090818809829 no 2821 0.18247886617607 4011 45595336
SGTC_3085 9117376 49.47 µM -0.90600833996403 0.163077484149348 no 2822 0.18246571907786 4062 16480349
SGTC_1413 3910-0535 34.4 µM -0.906390324748527 0.162974972761293 no 2823 0.182364646017283 3967 2876951
SGTC_1382 3002-2117 298 µM -0.906856088550624 0.162850034702999 no 2824 0.182241452394216 4048 1497314
SGTC_1965 Pectolinarigenin 58.4 µM -0.907806769805103 0.162595214101566 no 2825 0.181990160513092 3962 5320438 An anti-inflammatory.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.908005840710629 0.162541888002077 no 2826 0.181937567903523 4016 688664
SGTC_2433 5607874 27.82 µM -0.908925065023669 0.162295798489279 no 2827 0.181694841014565 3968 2252428
SGTC_136 0097-0015 404.482 µM -0.911922662831114 0.161494984662662 no 2828 0.180904715262389 3981 4861337
SGTC_1399 3562-5772 25 µM -0.912288092881883 0.161397535832152 no 2829 0.180808540378917 3916 23847490
SGTC_919 tnp00227 403.569 nM -0.912301047247985 0.161394082009511 no 2830 0.180805131601639 3963 1269246 A methoxyflavone. YNL221C POP1
SGTC_2998 9066762 71.4286 µM -0.915464835364924 0.160552013444926 no 2831 0.179973827443362 4016 4945196
SGTC_2681 menadione 3.18 µM -0.915634168864636 0.1605070249833 no 2832 0.179929401830799 4012 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2774 tamoxifen 10.92 µM -0.916622653079409 0.16024456923674 no 2833 0.179670204802071 3998 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1690 st023502 41.2 µM -0.917458128172908 0.160022958318581 no 2834 0.17945131236364 3984 24207482
SGTC_3318 9139014 38.6185 µM -0.91752910543121 0.160004140743672 no 2835 0.179432724224095 3980 16643984
SGTC_1443 4112-3303 14 µM -0.919657403445635 0.159440556128278 no 2836 0.178875909507801 4013 704433
SGTC_971 1315-0384 26.7 µM -0.919749627735924 0.159416164059609 no 2837 0.178851805991452 4020 6769120
SGTC_335 4077-0256 27.6 µM -0.919927514459167 0.159369122345435 no 2838 0.178805319724733 3979 3121989
SGTC_398 bronopol 33.3 µM -0.920668799650186 0.159173189132408 no 2839 0.178611685190396 3890 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1445 4239-0156 97.7 µM -0.920912441507756 0.159108825264325 no 2840 0.178548071218309 4104 4008346
SGTC_87 0100-0052 35.5 µM -0.921301206664235 0.159006158892208 no 2841 0.178446595653814 4060 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2867 9039098 71.43 µM -0.921652299573175 0.158913478439538 no 2842 0.178354984534974 3962 6463460
SGTC_2923 7992654 58.14 µM -0.924168507808162 0.158250293595513 no 2843 0.177699294611367 4011 2985126
SGTC_278 4092-0821 23.9 µM -0.924461313732739 0.158173238288642 no 2844 0.177623092249699 4005 877900
SGTC_40 0327-0103 19.753 µM -0.924492978363918 0.158164906845948 no 2845 0.177614852806305 3880 409036
SGTC_2368 9071271 200 µM -0.926280549203249 0.157695037046012 no 2846 0.177150100764212 4006 27209959
SGTC_2634 4'-methoxyflavone 100 µM -0.927591985252576 0.15735090481631 no 2847 0.176809628361977 4019 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1660 st012960 28.1 µM -0.928766310936406 0.15704317079901 no 2848 0.176505103549712 4009 24207266
SGTC_3280 9140961 49.47 µM -0.93124022676338 0.156396173266571 no 2849 0.175864656836906 4051 4901226
SGTC_1194 1488-0194 225 µM -0.931845122519944 0.156238243738515 no 2850 0.175708285783974 3964 1391452
SGTC_628 1636-0253 16 µM -0.935202188726523 0.155363672472248 no 2851 0.174842055389707 4010 4456143
SGTC_3171 9103192 49.47 µM -0.935281398933514 0.155343075991817 no 2852 0.174821649409057 4035 13018434
SGTC_2263 7948595 193.29 µM -0.936372363942281 0.155059583256903 no 2853 0.174540750908158 3987 2971371
SGTC_824 1304-0008 100 µM -0.938067804737862 0.154619692836301 no 2854 0.17410478294948 4042 768245
SGTC_701 4424-0219 185 µM -0.940280619958972 0.154046808882671 no 2855 0.173536818866965 4068 2911779
SGTC_3337 9144342 33.5465 µM -0.940718893628222 0.153933509411752 no 2856 0.173424467057905 4021 17682949
SGTC_1615 st002656 86.5 µM -0.942973146893896 0.153351626910877 no 2857 0.172847319174347 4009 1584458
SGTC_3141 9094609 49.47 µM -0.945675875191931 0.152655904441324 no 2858 0.172156965480991 3976 25236309 YDL196W YDL196W
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.948412641521986 0.151953556912498 no 2859 0.171459713162362 3998 688803
SGTC_868 0527-0199 213 µM -0.948733599062962 0.151871329122622 no 2860 0.171378060467218 3971 2849450
SGTC_337 1315-0038 354 µM -0.948776768092478 0.151860271679266 no 2861 0.171367080015269 3990 1626437
SGTC_2375 9072683 200 µM -0.948950262844448 0.151815837613257 no 2862 0.17132295451591 4040 16798029
SGTC_1612 st002233 45.4 µM -0.950151492328174 0.151508425467186 no 2863 0.17101764108009 4025 1035021
SGTC_3076 9116187 49.47 µM -0.951957599212557 0.151046995807416 no 2864 0.170559242992044 4022 27241210
SGTC_1602 st001878 87.6 µM -0.953516773039047 0.150649406235177 no 2865 0.170164150953755 4059 595405 YLR310C CDC25
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.954875912961144 0.150303394401524 no 2866 0.169820225992442 4105 6710655
SGTC_1338 1486-1223 76 µM -0.95641129642912 0.149913151770421 no 2867 0.169432239877104 4064 3444526
SGTC_2247 cerulenin 830 nM -0.957089980832043 0.149740868656177 no 2868 0.16926092010962 4091 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_721 1187-1332 279 µM -0.957316618001169 0.149683366547931 no 2869 0.169203735045172 3983 25730
SGTC_371 0195-0006 7.36 µM -0.958921903533194 0.149276497217812 no 2870 0.168799044730136 3879 3928593
SGTC_2944 9067346 25.62 µM -0.959706461550227 0.149077915136064 no 2871 0.168601485164321 4006 6473075
SGTC_1938 st074717 56.4 µM -0.962216054446203 0.148443889176447 no 2872 0.167970543124934 3901 17250979
SGTC_859 0439-0102 54.6 µM -0.962291807576926 0.14842477891306 no 2873 0.167951521529678 4056 610143
SGTC_1070 indatraline 8.81 µM -0.96527707219756 0.147672995332358 no 2874 0.16720302625624 4055 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1113 artemisinin 1.17947 µM -0.965841552863164 0.147531128549043 no 2875 0.167061736158801 4095 2240 An anti-malaria and mitochondrial poison.
SGTC_3118 9124250 49.47 µM -0.967282368226628 0.147169433066611 no 2876 0.166701447728382 3988 1504786
SGTC_175 3793-3120 23.7 µM -0.969912559383847 0.146510696590066 no 2877 0.16604503960722 4067 5322297
SGTC_1993 st073995 70.8 µM -0.969967668678269 0.146496915562155 no 2878 0.166031304049299 4038 3098394
SGTC_1298 1079-1278 263 µM -0.970286885008933 0.146417107140142 no 2879 0.165951756334689 4063 2840950
SGTC_1312 1218-2183 165 µM -0.972515464923745 0.145860745180406 no 2880 0.165397087530801 4084 6744073
SGTC_1513 0337-0559 19 µM -0.973781413676527 0.145545336376058 no 2881 0.165082541746675 4031 775073
SGTC_1902 st060212 70.5 µM -0.974372074474445 0.145398331357834 no 2882 0.164935914941117 4051 688944
SGTC_2031 5180455 200 µM -0.975185932128581 0.145195940260675 no 2883 0.164734019510849 4000 29949
SGTC_2417 cerulenin 830 nM -0.97527127538407 0.145174727984812 no 2884 0.164712857503319 4091 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2883 9059145 45.46 µM -0.975449530847318 0.145130428878525 no 2885 0.164668662346143 4035 16476510
SGTC_1271 0832-2808 169 µM -0.97847110932093 0.144380906185903 no 2886 0.163920686741624 4105 3663794
SGTC_1638 st008370 60.6 µM -0.979002427873622 0.144249379256064 no 2887 0.163789389944495 4017 24207134
SGTC_2199 6590217 200 µM -0.979644979783687 0.144090424649607 no 2888 0.163630696929126 3965 703109
SGTC_1529 apigenin 74 µM -0.979718850754237 0.144072158008537 no 2889 0.163612459189201 4099 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2286 7945697 125 µM -0.983612595342262 0.143111532099931 no 2890 0.162653014910437 4104 1245733
SGTC_389 tpck 16.7 µM -0.98528466723883 0.142700346227549 no 2891 0.162242131006494 4099 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3109 9122853 49.47 µM -0.985650917159014 0.142610386992485 no 2892 0.162152221469142 4119 1234709
SGTC_1264 0783-0040 158 µM -0.986848888866875 0.14231640604013 no 2893 0.161858361842823 3961 2855798
SGTC_3016 9080866 49.47 µM -0.987479065014601 0.142161926184691 no 2894 0.161703920481248 4060 17066299
SGTC_850 0388-0143 75.9 µM -0.988841947917396 0.141828220600284 no 2895 0.161370238499702 4036 67273
SGTC_2398 5228213 48.84 µM -0.989891108423728 0.141571692434463 no 2896 0.161113672995791 4101 80771 YMR134W ERG29
SGTC_3321 9137793 26.8275 µM -0.990595959333072 0.141399527376044 no 2897 0.160941455766225 4050 4904192
SGTC_2223 6903751 107.57 µM -0.992352023924323 0.1409712129399 no 2898 0.160512916794422 4054 5598863
SGTC_2079 5212404 121 µM -0.993043572614672 0.140802781928872 no 2899 0.160344360368034 4044 758462
SGTC_1975 st070967 30.8 µM -0.993938520391967 0.140585014558721 no 2900 0.160126399704544 4051 261391
SGTC_932 2857-0803 154 µM -0.99427018246123 0.14050436941895 no 2901 0.16004567405824 4149 674898
SGTC_2570 licareol 100 µM -0.995311257643793 0.140251431297687 no 2902 0.159792452085808 4089 443158
SGTC_2842 9000675 19.48 µM -0.995431742179541 0.140222178528666 no 2903 0.15976316341832 4144 2989072
SGTC_1302 1159-0335 255 µM -0.996808316013594 0.139888250578258 no 2904 0.159428780475325 4094 649284
SGTC_2402 5553605 200 µM -0.998106272290319 0.139573889040022 no 2905 0.159113914475418 4187 6758546
SGTC_483 fpl-64176 144 µM -0.998882630772643 0.139386086885008 no 2906 0.158925775624842 4149 3423
SGTC_455 paf C-16 10 µM -0.999014833958653 0.139354123894753 no 2907 0.158893752694835 4063 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1014 4130-3005 69.3 µM -1.00046641161663 0.139003501442393 no 2908 0.158542422293786 4094 743608
SGTC_679 0422-0091 41.4 µM -1.000559315145 0.138981081454616 no 2909 0.15851995388885 4085 627384 YHR062C RPP1
SGTC_99 0109-0120 622.8 µM -1.00387066353386 0.13818357621296 no 2910 0.157720479274353 4074 759414
SGTC_1613 st002381 52.1 µM -1.00408000853753 0.138133262634266 no 2911 0.157670025283166 4077 551167
SGTC_2074 5212007 75.395 µM -1.00558937839148 0.137770873295366 no 2912 0.157306567694747 3964 758611
SGTC_777 1315-0167 517 µM -1.00636731740962 0.13758434904344 no 2913 0.157119454568503 4108 4221767
SGTC_213 1246-0773 967 nM -1.00686875313618 0.137464212610645 no 2914 0.156998924775253 4094 6251622
SGTC_2984 9022109 38.96 µM -1.00718554976952 0.137388349846168 no 2915 0.156922807925387 4123 6459207
SGTC_3008 9078912 71.4286 µM -1.00721459922796 0.137381394851711 no 2916 0.156915829416186 4080 16648731
SGTC_2595 hexamethylquercetagetin 100 µM -1.00737032658992 0.137344114849782 no 2917 0.156878422739389 4080 386331
SGTC_187 1488-2104 32.728 µM -1.00916343906756 0.136915354442111 no 2918 0.156448128772652 4095 2852859
SGTC_499 genistein 192 µM -1.00976053919094 0.136772781984366 no 2919 0.156305015057727 4151 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_222 nsc-310342 10.666 µM -1.01095069880925 0.136488904717211 no 2920 0.156020013416272 4102 432556
SGTC_940 3232-1287 54.8 µM -1.01104100171425 0.136467382098972 no 2921 0.155998403013844 4037 1585493 YIL048W NEO1
SGTC_43 0570-0105 72.5 µM -1.01244529805087 0.136132983582399 no 2922 0.155662594534213 4105 1114046 YDL195W SEC31
SGTC_826 1683-5028 118 µM -1.01321800285407 0.135949222392574 no 2923 0.155478021620368 4141 722377
SGTC_1587 estradiol valerate 56.1 µM -1.01354043005077 0.135872594444051 no 2924 0.155401047434834 4153 13791 A steroid.
SGTC_979 1426-2828 121 µM -1.01526884082833 0.135462325128535 no 2925 0.154988846585966 4206 747872
SGTC_2026 5148700 152 µM -1.01565463923587 0.13537086496707 no 2926 0.154896937934306 4074 79838
SGTC_2343 7990716 14.84 µM -1.01578554405915 0.135339841341679 no 2927 0.154865760694544 4099 6456862
SGTC_466 geldanamycin 89.2 µM -1.01642849325714 0.135187537149326 no 2928 0.154712691442917 4031 5288382 HSP90 inhibitor.
SGTC_124 0136-0217 7.121 µM -1.01897527957993 0.134585399849591 no 2929 0.154107351318359 4155 3976905
SGTC_286 k060-0067 22.9 µM -1.02071726107057 0.134174604488691 no 2930 0.153694207072187 4109 5985051
SGTC_2300 7976697 71.57 µM -1.02218182885759 0.133829896156589 no 2931 0.153347424726871 4004 2236109
SGTC_723 4182-0001 115 µM -1.02546304150365 0.133059823803595 no 2932 0.152572377751227 4138 744821 YLR208W SEC13
SGTC_1500 4488-1866 171 µM -1.02762178705587 0.132554851358381 no 2933 0.152063885802396 4183 2900003
SGTC_447 ml7 120 µM -1.0285481054908 0.132338572864152 no 2934 0.151846037230257 4141 4216 Selective myosin light chain kinase inhibitor.
SGTC_1540 guanosine 70.6 µM -1.03229581485124 0.131466034231036 no 2935 0.15096678053149 3989 6802 Guanosine is a purine nucleoside
SGTC_2706 st078239 82.5 µM -1.03501547783664 0.130835336540787 no 2936 0.150330841472554 4096 15434492
SGTC_78 0336-0123 156.75 µM -1.03675787000127 0.130432371538963 no 2937 0.149924357243744 3939 6765896
SGTC_17 0960-0276 49.807 µM -1.03867265630012 0.129990527689494 no 2938 0.149478501124694 4110 6821114
SGTC_2424 5537928 59.2 µM -1.03890516679939 0.129936945679458 no 2939 0.14942442159973 4144 5382802
SGTC_875 0709-0210 25.7 µM -1.04156721197605 0.129324567323655 no 2940 0.148806188360548 4142 6251364
SGTC_2043 5101342 149 µM -1.04448378141304 0.128655937545654 no 2941 0.148130809533426 4139 678451
SGTC_840 0245-0196 390 µM -1.04581830197084 0.128350797141539 no 2942 0.147822464776615 4218 3827528
SGTC_311 1315-0136 58 µM -1.04755834852849 0.127953687739421 no 2943 0.147421068001248 4168 6759207
SGTC_2626 ethyl orsellinate 100 µM -1.04783551684339 0.127890511929257 no 2944 0.147357197859149 4116 75653 A natural product.
SGTC_1398 3558-0053 112 µM -1.0487845014881 0.127674371159355 no 2945 0.147138656091875 4051 4532369
SGTC_1201 1889-3372 45.9 µM -1.04893570248705 0.127639957081344 no 2946 0.147103856078168 4013 5392199
SGTC_988 1497-1057 103 µM -1.05126402657972 0.127110833384791 no 2947 0.146568672062931 4101 3533044
SGTC_2951 9072950 58.06 µM -1.05127303907698 0.127108788218043 no 2948 0.146566603010165 4113 16488155
SGTC_560 2332-1943 155 µM -1.05198611913092 0.126947044640845 no 2949 0.146402959102088 4104 21177716
SGTC_123 0083-0120 66.675 µM -1.05233314000965 0.126868383867085 no 2950 0.146323366076426 4112 16001701
SGTC_765 1319-0117 244 µM -1.05245204470032 0.126841439016072 no 2951 0.146296100672691 4106 3487746 YGL099W LSG1
SGTC_2784 7567673 72.73 µM -1.05387544496487 0.126519193263163 no 2952 0.145969973182209 4118 3471247
SGTC_1783 st039459 87.517 µM -1.05616134661853 0.126002878666369 no 2953 0.145447253465463 4251 729761
SGTC_2924 9010168 62.78 µM -1.05651121800487 0.125923983348244 no 2954 0.145367359212998 4235 2993929
SGTC_2067 5224629 34.075 µM -1.06018109371381 0.125098508978903 no 2955 0.144531110297082 4163 2835000
SGTC_622 1348-1566 26.3 µM -1.06053233263481 0.125019702546711 no 2956 0.144451244318161 4168 7340407
SGTC_1209 2323-2347 50.3 µM -1.0615182408171 0.124798682558231 no 2957 0.144227223861692 4165 5412760
SGTC_2151 5563267 85.4165 µM -1.06280034472307 0.124511670294416 no 2958 0.143936251589503 4196 5310824
SGTC_2539 epi(13)torulosol 80 µM -1.06308764964543 0.124447417450013 no 2959 0.143871102352267 4181 6708597
SGTC_482 fipronil 114 µM -1.06509580926295 0.123998960172443 no 2960 0.143416287756932 4254 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2970 9090938 41.86 µM -1.0717400320219 0.122523254202251 no 2961 0.141918407390741 4240 17217104
SGTC_122 0236-0016 402.397 µM -1.07747607039013 0.121259206928162 no 2962 0.140633817855582 4169 6808838
SGTC_228 caffeine 993.056 µM -1.07790635893971 0.121164755652848 no 2963 0.140537773673065 4189 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1609 st001574 46.4 µM -1.07985281066085 0.120738142737531 no 2964 0.140103864914939 4155 3960012
SGTC_1279 0874-0590 65.2 µM -1.08206765715699 0.120253991866832 no 2965 0.139611232954011 4235 3523074
SGTC_1995 st072814 61.1 µM -1.08375482374546 0.119886107290688 no 2966 0.139236760241709 4152 5769371
SGTC_1933 st074711 15.9 µM -1.08421221149131 0.119786511309997 no 2967 0.13913535925465 4164 17250958
SGTC_1564 D-Arginine 115 µM -1.08478399195144 0.11966208843796 no 2968 0.139008668576601 4189 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2344 7990960 76.95 µM -1.09294936014547 0.117895194216643 no 2969 0.137208017186249 4165 140813
SGTC_1343 1487-0095 224 µM -1.09590152808329 0.117260944094705 no 2970 0.136560935147039 4200 4560101 YGL055W OLE1
SGTC_1514 1189-1591 158 µM -1.0978291633085 0.116848113276536 no 2971 0.136139547172652 4214 767698 YMR146C TIF34
SGTC_1522 st012842 45.6 µM -1.10008400440872 0.116366515296467 no 2972 0.135647761248588 4044 3491067 YOR116C RPO31
SGTC_1994 st072947 40.9 µM -1.10126624780067 0.116114570511519 no 2973 0.135390398206139 4242 5286565 YDL195W SEC31
SGTC_2193 5925765 200 µM -1.10308170871058 0.115728436570532 no 2974 0.134995841679649 4191 877370
SGTC_2425 5628681 7.85 µM -1.10387811572237 0.115559335314536 no 2975 0.134823006591751 4270 5714958
SGTC_2378 9074213 121.43 µM -1.10902547225558 0.114470629388495 no 2976 0.133709596771812 4164 657714
SGTC_2264 7948757 110.76 µM -1.10923377494975 0.114426725984564 no 2977 0.133664672892414 4163 2971411
SGTC_3000 9075062 71.4286 µM -1.11152102095834 0.113945437566654 no 2978 0.133172073480859 4156 17057871
SGTC_344 k064-0035 6.43 µM -1.11173248560637 0.113901013559889 no 2979 0.133126593953177 4147 5088750
SGTC_609 0986-0026 86.3 µM -1.1135280158934 0.113524309913396 no 2980 0.13274086144581 4168 2848610
SGTC_756 0508-1999 28.3 µM -1.11613608001551 0.112978719704171 no 2981 0.132181945108246 4222 6753853
SGTC_3099 9120367 49.47 µM -1.1193263933614 0.112313874822914 no 2982 0.131500459977619 4257 24824940
SGTC_197 4544-0043 41.561 µM -1.11939537806113 0.112299529712072 no 2983 0.131485750944431 4207 896523
SGTC_1866 st057638 64 µM -1.12159830231209 0.111842128131844 no 2984 0.131016636903866 4202 688802
SGTC_2822 7994718 71.43 µM -1.12209412434433 0.111739362659099 no 2985 0.130911210927309 4182 1018011
SGTC_1879 gemcitabine 100 µM -1.12245927943839 0.111663722785231 no 2986 0.130833605982339 4189 60750 A nucleoside analog which inhibits DNA replication.
SGTC_463 ikarugamyin 104 µM -1.1228085991662 0.111591397409739 no 2987 0.130759396226963 4347 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1037 k284-1091 78.7 µM -1.12351093151909 0.111446083512686 no 2988 0.130610280264907 4202 3334711
SGTC_2069 5228469 200 µM -1.12413905293064 0.111316238761706 no 2989 0.13047702006026 4223 2835210
SGTC_3282 9108498 15.4605 µM -1.12427988467975 0.111287141004526 no 2990 0.130447154561956 4186 16459645
SGTC_3267 9137951 49.47 µM -1.12470836362192 0.111198644906157 no 2991 0.130356318211137 4249 16643986
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.13088999665116 0.10992752204837 no 2992 0.129050697086426 4324 5282309
SGTC_302 1094-0063 18.9 µM -1.13338119942451 0.109418217552689 no 2993 0.128527102891139 4205 5440289
SGTC_1024 4507-0395 26 µM -1.13343395304307 0.109407450894889 no 2994 0.12851603124467 4280 4201836
SGTC_2142 5622915 118.518 µM -1.13788489037477 0.108501783426941 no 2995 0.127584275658023 4238 5322196
SGTC_2988 9073640 71.4286 µM -1.13961084437048 0.108152045122266 no 2996 0.127224232694126 4279 9102229
SGTC_1482 3346-2049 8.48 µM -1.14263571360202 0.107541060209951 no 2997 0.126594935549363 4243 3826804
SGTC_259 usnic acid 108.925 µM -1.14379217829926 0.107308127631947 no 2998 0.126354917199909 4313 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_842 0271-0008 11.1 µM -1.14456775095777 0.107152117388741 no 2999 0.126194128794334 4272 1221709
SGTC_1930 st074634 34.3 µM -1.14796972853335 0.106469725149901 no 3000 0.125490530359946 4139 684253 YOR116C RPO31
SGTC_613 3914-0030 117 µM -1.14826387081658 0.106410871758759 no 3001 0.125429824575939 3943 1145395
SGTC_2515 chrysin 20.77 µM -1.14986741236184 0.106090440593854 no 3002 0.125099242322303 4263 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_608 k048-0125 159 µM -1.15133619115703 0.10579755091547 no 3003 0.124796976805525 4282 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_878 0828-0289 13.7 µM -1.15348094786182 0.105370914840124 no 3004 0.124356516567954 4179 745350 YLR208W SEC13
SGTC_3169 9102970 49.47 µM -1.15585587710505 0.104899946361691 no 3005 0.123870056461363 4304 17027839
SGTC_1293 1000-1278 195 µM -1.15879822409034 0.104318570300144 no 3006 0.123269220788443 4285 678847
SGTC_2851 9015922 71.43 µM -1.15956430916085 0.104167584017566 no 3007 0.123113119654387 4273 2996893
SGTC_676 falcarinol 140 µM -1.16142976078048 0.103800588310625 no 3008 0.122733585993441 4285 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2957 9076800 11.52 µM -1.16299395929214 0.103493582683085 no 3009 0.122415976653309 4225 16459615
SGTC_3316 9136639 10.545 µM -1.16511694676334 0.103077958374627 no 3010 0.121985828993423 4249 4903665
SGTC_3221 9128209 49.47 µM -1.16655756167005 0.102796615686263 no 3011 0.121694545042969 4283 16460723
SGTC_1568 digitonin 820 nM -1.17057003912105 0.10201594743366 no 3012 0.120885823076884 4243 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_203 k066-0004 30.888 µM -1.17122666525171 0.101888605996978 no 3013 0.12075383985612 4342 6795412
SGTC_1749 st037932 54.2 µM -1.17476159493265 0.101205054228193 no 3014 0.120045054503672 4296 594497
SGTC_2654 protoveratrine a 100 µM -1.17699290664493 0.100775307884181 no 3015 0.119599168735057 4260 5702278 A heart drug and vasodilator.
SGTC_1341 1486-1360 280 µM -1.17984416249623 0.100228100217934 no 3016 0.119031100636745 4252 3976547
SGTC_589 1227-0070 34.1 µM -1.17988738130595 0.100219822465273 no 3017 0.119022504648103 4325 2841384
SGTC_3181 9108277 49.47 µM -1.18382203824506 0.0994683020766565 no 3018 0.118241758220655 4229 17097298
SGTC_2968 9090663 33.37 µM -1.18442253395862 0.0993539704986355 no 3019 0.118122922245532 4227 25236811
SGTC_1669 st015249 58.4 µM -1.18730630293047 0.0988062527248927 no 3020 0.117553411422899 4360 722793
SGTC_1317 1273-0028 910 nM -1.19044740880928 0.0982121763111263 no 3021 0.116935294425852 4291 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_162 k030-0015 37.8 µM -1.19204027824601 0.0979119191362321 no 3022 0.116622726155746 4351 1809920 YMR134W ERG29
SGTC_978 1416-0512 87.4 µM -1.1936829906041 0.0976029717805936 no 3023 0.116300998272087 4352 6814003
SGTC_1489 4065-0444 182 µM -1.19703352816641 0.096975048293861 no 3024 0.115646743352002 4283 2877968
SGTC_1013 4112-3890 241 µM -1.19990565859154 0.0964391478853762 no 3025 0.115087991044639 4229 705171
SGTC_1913 st060213 96.1 µM -1.20123120704497 0.0961925538031359 no 3026 0.114830763572747 4303 688959
SGTC_2213 7173844 200 µM -1.20317116693431 0.0958324957329519 no 3027 0.114455045045287 4279 892728
SGTC_375 3970-0961 9.27 µM -1.20642693347091 0.0952304525285573 no 3028 0.113826458127442 4237 2898222
SGTC_1530 rhein 70.4 µM -1.20831414478641 0.0948827545216175 no 3029 0.113463224855848 4345 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_132 0417-1715 25.805 µM -1.21595744519232 0.0934841235822558 no 3030 0.112000566580791 4290 6769098
SGTC_3153 9100258 49.47 µM -1.21617142535662 0.0934451881140908 no 3031 0.111959813214978 4228 25236848
SGTC_3353 9151644 39.2805 µM -1.21651258954844 0.0933831352305417 no 3032 0.111894859080857 4320 4909158
SGTC_3273 9137859 49.47 µM -1.22184763266303 0.0924167237557468 no 3033 0.1108826259223 4404 2377234
SGTC_54 0159-0055 9 µM -1.22270105359902 0.0922628206985125 no 3034 0.110721314451104 4303 3319099
SGTC_440 fluspirilene 35.1 µM -1.22271166871856 0.092260907598779 no 3035 0.110719309067431 4364 3396 An atypical antipsychotic.
SGTC_2409 alverine citrate 63.97 µM -1.2247729945696 0.0918899633277052 no 3036 0.110330381322956 4379 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2377 9073351 62.6 µM -1.22823076916214 0.091270204618568 no 3037 0.109680175629245 4288 7337946 YHR072W ERG7
SGTC_2427 5545055 42.75 µM -1.22973283259695 0.0910019479864313 no 3038 0.109398583845639 4243 5372858
SGTC_1058 3448-5425 97.3 µM -1.23019153004497 0.0909201449409276 no 3039 0.109312695441644 4251 7279705
SGTC_2191 5911152 200 µM -1.23039086450859 0.0908846131018618 no 3040 0.109275386337038 4329 2875902
SGTC_795 0685-0265 78 µM -1.23133935243702 0.0907156840195128 no 3041 0.109097984736726 4315 302754
SGTC_7 0192-1582 4.227 µM -1.23190872468232 0.090614388784254 no 3042 0.108991590967266 4352 252616
SGTC_707 0865-0008 204 µM -1.23212004522798 0.0905768147777317 no 3043 0.108952122269353 4346 723043
SGTC_509 pifithrin 175 µM -1.23429631853096 0.090190533549864 no 3044 0.108546253630133 4385 4817 A p53 inhibitor.
SGTC_768 0384-0033 77.3 µM -1.23580300391497 0.0899238196968251 no 3045 0.108265899069314 4268 3965305 YMR134W ERG29
SGTC_596 1155-0152 116 µM -1.23611014713852 0.0898695211190621 no 3046 0.108208811790409 4328 280313
SGTC_1654 st012436 41.8 µM -1.2384766493775 0.0894519739603076 no 3047 0.10776968753742 4322 4323132
SGTC_362 0310-0100 9.03 µM -1.23943316467 0.0892836158804341 no 3048 0.107592562903166 4375 790235
SGTC_1072 oxiconazole 14.9 nM -1.23947175214376 0.0892768289760979 no 3049 0.107585421794939 4297 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3083 9117465 49.47 µM -1.23961973400069 0.0892508049508523 no 3050 0.107558039015706 4299 16420915
SGTC_1895 st058434 18.3 µM -1.24010009565678 0.0891663676560228 no 3051 0.107469186804776 4331 5393175
SGTC_1840 st055363 71 µM -1.24094208580867 0.0890185072554083 no 3052 0.107313572037514 4358 676033
SGTC_2412 st077135 33.4 µM -1.24130147464939 0.088955451220953 no 3053 0.107247200072269 4375 13258915
SGTC_771 0250-0039 27.3 µM -1.24461406819292 0.0883758099901242 no 3054 0.106636823306907 4285 3005115
SGTC_2674 ligustilide 100 µM -1.24690462747307 0.0879766544692822 no 3055 0.106216234897771 4372 5319022 A signalling regulator.
SGTC_2900 5328528 85.29 µM -1.251018024434 0.0872632264164078 no 3056 0.105463950724949 4329 795359
SGTC_2210 7115885 190.385 µM -1.25211220037957 0.0870741817186495 no 3057 0.10526449133079 4420 2927039
SGTC_2921 7974240 10.71 µM -1.2531802954719 0.0868899382875431 no 3058 0.105070049657865 4417 2979074 YDR527W RBA50
SGTC_1053 3366-3204 134 µM -1.2537788918941 0.0867868095060937 no 3059 0.104961191737629 4336 3632071 YPR165W RHO1
SGTC_3122 9126309 49.47 µM -1.25896697512383 0.0858968128556841 no 3060 0.104021130302568 4406 17591206
SGTC_2558 carylophyllene oxide 100 µM -1.2608749267978 0.0855712343612814 no 3061 0.103676956531551 4453 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2726 cimetidine 79.27 µM -1.26179357136228 0.0854148041107368 no 3062 0.103511538014773 4324 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_948 3448-0295 75.3 µM -1.26219192994983 0.0853470367306871 no 3063 0.103439865940417 4316 678569
SGTC_1992 st073643 23.3 µM -1.26229800728234 0.0853289980154073 no 3064 0.103420786741747 4322 3161292
SGTC_2931 9014674 55.67 µM -1.26265641024902 0.0852680718230188 no 3065 0.103356342841786 4298 2996810
SGTC_1769 st044406 64.4 µM -1.26289114102505 0.0852281867718457 no 3066 0.103314152054458 4305 670903
SGTC_2321 7390090 138.78 µM -1.26334334314869 0.0851513887687793 no 3067 0.103232907959241 4354 649046
SGTC_1397 3532-0190 20.1 µM -1.26449460721364 0.0849561023624103 no 3068 0.103026277553789 4275 5322280
SGTC_1001 4048-4355 44.4 µM -1.26551138240854 0.0847839083690256 no 3069 0.102844035361642 4326 21824233
SGTC_2141 5621638 7.665 µM -1.26664824513537 0.084591687223608 no 3070 0.102640546716493 4366 2856238
SGTC_2816 7982706 58.44 µM -1.26744964469443 0.0844563828678723 no 3071 0.10249727905827 4329 2981853
SGTC_1414 3917-0015 5.4 µM -1.26874020631508 0.08423883217725 no 3072 0.102266868695201 4344 6618702
SGTC_819 1013-0258 27.7 µM -1.26877819597742 0.0842324346173966 no 3073 0.102260091925178 4336 5753198
SGTC_2830 7992007 71.43 µM -1.26894492299171 0.0842043616583092 no 3074 0.102230354258847 4212 1952075
SGTC_2697 mebhydrolin 72.4 µM -1.26915756771476 0.0841685674137556 no 3075 0.102192435773149 4393 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_77 0828-0286 12.516 µM -1.2757108901555 0.0830710460862344 no 3076 0.101028868752152 4248 745345
SGTC_2299 7976368 114.88 µM -1.2760537821926 0.0830139177701041 no 3077 0.100968253942982 4368 2979718
SGTC_620 0109-0052 432 µM -1.27634976000094 0.0829646294731488 no 3078 0.100915953728686 4384 493037
SGTC_1381 2324-0066 62.1 µM -1.28069753591918 0.082243141944444 no 3079 0.100149962807359 4383 10885928
SGTC_970 1315-0089 19.5 µM -1.28326535766149 0.0818192525761753 no 3080 0.0996995625374742 4312 6811083 YLR033W RSC58
SGTC_380 3970-0968 6 µM -1.28647528151213 0.0812916850365648 no 3081 0.0991386200566965 4237 2891601
SGTC_2600 tangeritin 87.95 µM -1.28653858719846 0.0812813062864348 no 3082 0.0991275804813258 4269 68077 A bioactive flavone.
SGTC_1205 4161-2785 76 µM -1.28879457298528 0.0809120973944863 no 3083 0.0987347566252456 4377 3498106
SGTC_2712 st079126 47.7 µM -1.28879602777988 0.0809118597156559 no 3084 0.0987345036770252 4352 3152970
SGTC_514 4466-0038 2.65 nM -1.29118314138322 0.0805225716758577 no 3085 0.0983200897583053 4157 5722064
SGTC_1665 st014639 11.4 µM -1.29325820460281 0.0801853234495418 no 3086 0.0979608854420751 4431 981133 YIL048W NEO1
SGTC_1178 0988-0033 191 µM -1.29393223586953 0.0800760070144219 no 3087 0.0978444142828252 4398 5392207
SGTC_1117 retinoic acid 1.10837 µM -1.29681449380116 0.0796098243653078 no 3088 0.0973475112538613 4400 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_226 1,3-diallylurea 8.28947 mM -1.29707346933898 0.0795680378509221 no 3089 0.097302954522838 4297 74537 YKL182W FAS1
SGTC_2440 5628896 157.78 µM -1.29833121704706 0.0793653323143751 no 3090 0.0970867718639676 4338 5522048
SGTC_1308 1187-1617 41.4 µM -1.29972516112794 0.0791411335553034 no 3091 0.0968475917505337 4396 2882570
SGTC_1927 st060202 13.8 µM -1.30067703780108 0.0789883116806225 no 3092 0.0966845126235366 4288 688887
SGTC_342 k048-0088 23.3 µM -1.31099752880687 0.0773456993159965 no 3093 0.0949292992528334 4367 6820570
SGTC_899 1083-0020 478 µM -1.31210052982286 0.0771716915337088 no 3094 0.0947431086276404 4437 767123
SGTC_2091 4-phenylthiadiazole 200 µM -1.31246673083461 0.0771139860316646 no 3095 0.0946813520986424 4378 270010
SGTC_2170 morpholine 200 µM -1.31260346395448 0.0770924482050857 no 3096 0.0946583008884212 4412 121171 Reacts with secondary amines.
SGTC_332 4112-0506 40.9 µM -1.31385497153528 0.076895526515148 no 3097 0.0944475071329693 4347 2790355
SGTC_881 0833-0569 170 µM -1.31789666657984 0.0762621867083598 no 3098 0.0937691208751247 4395 5418700
SGTC_1332 1480-0653 17.5 µM -1.32216382187938 0.0755978333746097 no 3099 0.0930568026298289 4379 5749438
SGTC_1758 st042942 75.2445 µM -1.32518432279342 0.0751302434169127 no 3100 0.0925550118849034 4359 669317
SGTC_382 3229-0966 23.2 µM -1.32618190744082 0.0749762973314137 no 3101 0.0923897253336211 4423 5722370
SGTC_2254 7938975 95.19 µM -1.32627052478628 0.0749626336515674 no 3102 0.0923750531843413 4438 2969277
SGTC_1764 st044502 93.5 µM -1.32648811706165 0.0749290917174391 no 3103 0.0923390342976234 4403 8407
SGTC_1853 st056710 91.2 µM -1.33612290446013 0.0734553337784953 no 3104 0.0907545523470967 4431 269167
SGTC_906 1165-0455 526 µM -1.34014018913426 0.0728474304943167 no 3105 0.0900998861523765 4387 3252859
SGTC_131 0141-0277 33.849 µM -1.34364059907808 0.072320888340566 no 3106 0.0895323171522486 4367 1547771
SGTC_772 k072-0172 35.3 µM -1.35562426030876 0.0705403369870614 no 3107 0.0876093744067455 4448 5861980
SGTC_2020 4017018 200 µM -1.36002707902784 0.0698946907333387 no 3108 0.0869106774524756 4449 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3029 9088683 49.47 µM -1.3616523671513 0.0696575048161904 no 3109 0.0866538101624304 4425 25236615
SGTC_1038 k292-0204 154 µM -1.36654356054436 0.0689474477577458 no 3110 0.0858842090862678 4353 4454212
SGTC_1978 st071761 42 µM -1.36786639428746 0.0687563730530001 no 3111 0.0856769502778207 4430 5147680
SGTC_962 1254-0300 21.5 µM -1.37237813323164 0.0681077519845371 no 3112 0.0849728768614127 4385 7340576
SGTC_2360 9040895 200 µM -1.37485979986224 0.0677529993531305 no 3113 0.084587457187137 4438 4914414
SGTC_2086 5274770 176.623 µM -1.3866136419909 0.0660921532680333 no 3114 0.0827798031092603 4461 689278
SGTC_2367 9070478 135.38 µM -1.38828696902041 0.0658582950816182 no 3115 0.0825248393138303 4364 572802
SGTC_2183 6420625 130.508 µM -1.39279954075476 0.0652308306980279 no 3116 0.0818402086702382 4454 2897619
SGTC_2938 9059746 27.26 µM -1.39585822556925 0.0648081707723223 no 3117 0.0813785962503508 4425 6471769
SGTC_649 1123-0311 367 µM -1.39636611906797 0.0647381945673915 no 3118 0.0813021361794506 4337 693629 YIL048W NEO1
SGTC_2540 epiandrosterone 100 µM -1.39904454982823 0.064370137725761 no 3119 0.0808998120661929 4481 441302 A steroid.
SGTC_1899 st063254 59.6 µM -1.40083335006062 0.0641252365472886 no 3120 0.0806319566144448 4395 3093813
SGTC_1272 0839-0021 27 µM -1.40305664378 0.0638218600315418 no 3121 0.0802999742623515 4473 5027250
SGTC_2459 5811157 9.22 µM -1.40479395119076 0.0635855760559293 no 3122 0.080041279149712 4381 2870684 YBR192W RIM2
SGTC_791 1348-1292 225 µM -1.4104851770827 0.0628163013641013 no 3123 0.0791982351332302 4401 5437054
SGTC_1223 0764-0573 147 µM -1.4161515428728 0.0620576108046644 no 3124 0.0783655699295745 4440 1609797
SGTC_1983 st071813 46.9 µM -1.41640328875298 0.062024070235502 no 3125 0.0783287307928901 4509 11838595
SGTC_1729 st035615 45.989 µM -1.41651895889172 0.0620086640325148 no 3126 0.0783118086512876 4450 17385451
SGTC_2786 7743617 45.45 µM -1.42120595019893 0.0613869080639235 no 3127 0.0776284476960269 4381 583674
SGTC_1457 k015-0032 57.3 µM -1.42415391481441 0.0609983456209247 no 3128 0.0772009610746921 4426 4302660
SGTC_2261 9010538 184.68 µM -1.42496060784979 0.0608923535539413 no 3129 0.0770842941569666 4441 6457250
SGTC_3193 9111931 49.47 µM -1.42596421751971 0.0607606895260946 no 3130 0.0769393355235708 4445 17087244
SGTC_510 ag-490 170 µM -1.42676701801008 0.0606555301122147 no 3131 0.0768235304607517 4585 5328779
SGTC_2862 9027634 71.43 µM -1.42848640771375 0.0604307850104077 no 3132 0.0765759520699373 4413 5012562
SGTC_474 dl-dihydrosphingosine 5 µM -1.43074761139132 0.060136210861594 no 3133 0.0762512812382982 4444 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_19 0279-0214 38.434 µM -1.43266922997227 0.0598867602127861 no 3134 0.0759761934578973 4523 3566274 YBR002C RER2
SGTC_235 0330-0087 5 mM -1.43309449720209 0.0598316647747984 no 3135 0.075915416909063 4495 46494818 YHR062C RPP1
SGTC_3067 9117431 49.47 µM -1.43354184552767 0.0597737514834623 no 3136 0.0758515246298238 4464 17150885
SGTC_1365 1672-3266 55.4 µM -1.43359847632938 0.0597664232460782 no 3137 0.0758434392877579 4465 6415873
SGTC_602 3130-1533 38.1 µM -1.44337449928181 0.0585118840004478 no 3138 0.0744575018139363 4508 720941
SGTC_2400 5203494 178.7 µM -1.44440331778968 0.0583810691374839 no 3139 0.0743127790024992 4372 6777674
SGTC_708 3448-5400 146 µM -1.45171208155808 0.0574583566548479 no 3140 0.0732908392886013 4415 3462195
SGTC_2888 9058547 12.99 µM -1.45691666390748 0.0568083139829742 no 3141 0.0725696927822486 4400 16476514
SGTC_2749 bexarotene 57.39 µM -1.45782376030762 0.0566956143570845 no 3142 0.0724445636494023 4474 82146 An retinoic acid receptor inhibitor.
SGTC_60 0986-0278 202 µM -1.46365743752706 0.0559750288876074 no 3143 0.0716437851752541 4422 3110598
SGTC_1374 2889-5571 141 µM -1.46976716997262 0.0552281096491155 no 3144 0.0708124117786274 4474 2853281
SGTC_1356 1502-0781 85.8 µM -1.47398735654576 0.0547168015422393 no 3145 0.0702424976995402 4489 567702
SGTC_666 0272-0154 136 µM -1.47532598975671 0.0545553999518386 no 3146 0.0700624611680114 4466 6870312
SGTC_1377 2944-0135 198 µM -1.47747405067072 0.0542971911811016 no 3147 0.0697743045924716 4485 1894137
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.48085883594038 0.0538922845721807 no 3148 0.0693220971139191 4534 165521
SGTC_220 paclitaxel 373.376 µM -1.48159815203607 0.0538041624399281 no 3149 0.0692236255188024 4461 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_91 0417-1751 58.384 µM -1.48301606904361 0.0536354743756676 no 3150 0.0690350707416466 4580 6795624
SGTC_547 1120-0019 610 nM -1.48347915218293 0.053580472716516 no 3151 0.0689735757124888 4470 3676939
SGTC_2865 9030313 51.95 µM -1.48610839852138 0.0532690364653441 no 3152 0.0686252255956488 4474 42562754
SGTC_3224 9130643 49.47 µM -1.487010867799 0.0531624696761184 no 3153 0.0685059703181444 4494 17644395
SGTC_3286 9117135 37.221 µM -1.48774999552512 0.0530753168012346 no 3154 0.0684084186699727 4436 3438150
SGTC_858 0438-0351 2.77 µM -1.49160660514441 0.0526224081522284 no 3155 0.0679011528111104 4468 2799119
SGTC_767 0929-0023 86 µM -1.49768875250967 0.0519143776819001 no 3156 0.0671070677188906 4521 1204563
SGTC_2597 laccaic acid a 100 µM -1.49803941375584 0.051873788692439 no 3157 0.0670615052779193 4473 5491415 A textile dye.
SGTC_2575 plumbagin 510 nM -1.49848265044245 0.0518225201977174 no 3158 0.0670039484756638 4416 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2195 6536160 144.242 µM -1.49941466683664 0.0517148466902456 no 3159 0.0668830454992447 4495 3834386
SGTC_3172 9105863 49.47 µM -1.50692496303781 0.0508536783445858 no 3160 0.0659149460048076 4599 2348785
SGTC_3070 9117005 49.47 µM -1.5076848747586 0.0507671828850954 no 3161 0.0658175992196426 4596 8779016
SGTC_822 1487-0950 154 µM -1.50815255746121 0.0507140080820554 no 3162 0.0657577431924846 4500 1958375
SGTC_2187 6125751 200 µM -1.5131400537218 0.0501496920771474 no 3163 0.0651220436865553 4527 874498
SGTC_1920 st075728 45.7 µM -1.5132790645688 0.0501340355350383 no 3164 0.0651043941089932 4479 3400306
SGTC_2256 7954252 200 µM -1.51618445630074 0.0498076974435323 no 3165 0.0647363586547023 4500 2972920
SGTC_1864 st057645 30.4 µM -1.5200801111034 0.0493727932541108 no 3166 0.0642454212991419 4537 688666
SGTC_1632 st005650 90 µM -1.52196074519893 0.0491639302875348 no 3167 0.0640094584502356 4535 2759605
SGTC_1326 1431-2094 10.8 µM -1.53593717329593 0.0476337362352929 no 3168 0.0622768949608252 4524 616278
SGTC_1185 1319-0113 81.3 µM -1.53674964878832 0.0475459697819402 no 3169 0.0621773139276571 4567 4672763
SGTC_953 1188-0045 9.7 µM -1.54496501977523 0.0466657755377938 no 3170 0.0611773623472348 4496 6144426
SGTC_1368 1852-0141 284 µM -1.5456554793766 0.046592399297576 no 3171 0.0610938973728474 4500 2838987
SGTC_3128 9127691 49.47 µM -1.54608361647155 0.0465469470115937 no 3172 0.061042187506208 4525 41316314
SGTC_3187 9109394 49.47 µM -1.54772730891555 0.0463727782795665 no 3173 0.0608439821098016 4521 17098090
SGTC_928 2764-0428 58.7 µM -1.55007373635858 0.0461250533869197 no 3174 0.0605619094810233 4541 662578
SGTC_1817 st052116 64.4 µM -1.5515846702848 0.0459660993718632 no 3175 0.0603808167503351 4546 4361398
SGTC_3305 9127027 53.8275 µM -1.55188776891694 0.0459342656997902 no 3176 0.0603445399983211 4472 41905295
SGTC_2066 5222451 176 µM -1.55650461586948 0.045451556512024 no 3177 0.0597940729508911 4463 2281147
SGTC_2236 dapsone 200 µM -1.56620088715035 0.0444510549433561 no 3178 0.0586507975521936 4558 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3331 9141060 1.957 µM -1.56742291903736 0.0443262295007072 no 3179 0.0585079351390858 4477 4906567 YPR165W RHO1
SGTC_886 0866-0150 153 µM -1.57070479170443 0.0439923976105944 no 3180 0.0581256178340328 4553 271463
SGTC_1125 tnp00248 1.32998 µM -1.57103034532505 0.0439593931470094 no 3181 0.0580878001737966 4560 24207736
SGTC_2954 9074818 52.69 µM -1.57669365655729 0.0433884382097006 no 3182 0.0574330153520956 4532 16648742
SGTC_1040 k898-0338 155 µM -1.57750209724636 0.0433074246202666 no 3183 0.0573400199578442 4514 20969351
SGTC_2727 riluzole 51.77 µM -1.57789068485876 0.0432685278647721 no 3184 0.057295362684812 4579 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2892 9047358 58.44 µM -1.58119266803396 0.0429391439085978 no 3185 0.0569169956480394 4536 6466771
SGTC_2529 gangaleoidin 93.61 µM -1.58195391957468 0.0428634946235827 no 3186 0.0568300452077793 4516 4565183
SGTC_1175 0741-0056 27.6 µM -1.58217537516455 0.0428415077354624 no 3187 0.0568047701192427 4599 765927
SGTC_14 0354-0009 295 µM -1.58219209126596 0.0428398484722988 no 3188 0.0568028626426832 4632 1713507
SGTC_1154 4088-0362 150 µM -1.58243478146585 0.0428157645603512 no 3189 0.0567751749142712 4541 6618304
SGTC_37 0566-0070 1.56 µM -1.58605053313336 0.042458241626378 no 3190 0.0563639234207316 4460 1626686
SGTC_1394 3474-0001 65.7 µM -1.58623140165439 0.0424404210805605 no 3191 0.0563434134683827 4529 5017666 YIL048W NEO1
SGTC_1862 st057513 3.81 µM -1.58689707863659 0.0423748856080326 no 3192 0.0562679783451489 4525 5393163
SGTC_8 0354-0001 70 µM -1.59105880755166 0.0419670196105618 no 3193 0.0557981708683715 4540 4993152
SGTC_2560 caryophyllene 100 µM -1.59218159279501 0.0418575282498523 no 3194 0.0556719539730871 4565 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_338 4055-0136 114 µM -1.59313091485664 0.041765133174008 no 3195 0.0555654126773291 4515 2900563
SGTC_1278 0874-0585 172 µM -1.61107626572242 0.0400494222021553 no 3196 0.0535815503625841 4568 766306
SGTC_805 3852-0218 479 µM -1.61592271402528 0.0395960190606448 no 3197 0.0530555120009019 4537 6615355
SGTC_1846 st056244 14.8 µM -1.61800662496287 0.0394023491558603 no 3198 0.0528305849675427 4567 5393182
SGTC_3207 9114163 49.47 µM -1.62775805304502 0.0385063086915397 no 3199 0.0517880990763871 4526 849233
SGTC_1714 st033236 13.627 µM -1.6280667560874 0.0384782160077237 no 3200 0.0517553658106447 4548 2916566
SGTC_856 0433-0016 11.3 µM -1.63120026967243 0.0381940034165171 no 3201 0.0514240342207452 4585 3911780
SGTC_2011 4012611 177 µM -1.64219654871316 0.0372101477080363 no 3202 0.0502746388608915 4533 2049887
SGTC_2269 7935389 174.42 µM -1.6440669848724 0.03704487555981 no 3203 0.0500811833368846 4579 97605
SGTC_198 3454-2873 16.191 µM -1.64720505124417 0.0367689434045735 no 3204 0.0497579529633544 4567 710957
SGTC_1596 piperlongumine 63 µM -1.64828059900138 0.0366747574711458 no 3205 0.049647552018423 4574 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2512 diallyl trisulfide 49.23 µM -1.65146263376194 0.0363972610874322 no 3206 0.0493220722999034 4613 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2114 5491910 81.25 µM -1.65311809587284 0.036253573803946 no 3207 0.0491534155794164 4580 2849228
SGTC_441 propafenone 146 µM -1.65489075561909 0.0361002294408478 no 3208 0.0489733298966439 4555 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1777 st045864 34.765 µM -1.66173683619571 0.0355129867914084 no 3209 0.0482827759129587 4589 4691462
SGTC_2285 7945142 200 µM -1.66410791160909 0.0353114359276713 no 3210 0.0480454331480742 4578 2970608
SGTC_3206 9114350 49.47 µM -1.6891321042005 0.0332409508864663 no 3211 0.045597058357114 4451 17087243
SGTC_3228 9131799 49.47 µM -1.69488872608099 0.0327790768394749 no 3212 0.0450482657972998 4611 17015818
SGTC_1255 0566-0045 221 µM -1.6960155582638 0.0326892892028141 no 3213 0.0449414668382646 4589 2788469
SGTC_448 monastrol 171 µM -1.69738822995311 0.0325801868145324 no 3214 0.0448116431593851 4512 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1709 st033179 39.1045 µM -1.70275271382415 0.0321566846824696 no 3215 0.0443071776981422 4604 573381
SGTC_1051 3253-3903 78 µM -1.70887378252334 0.0316790151831344 no 3216 0.0437371659258559 4588 5509239
SGTC_2582 agaric acid 100 µM -1.71036239866461 0.0315637387345101 no 3217 0.0435994398383396 4220 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1087 pterostilbene 9.05 µM -1.71383958694658 0.0312958202682125 no 3218 0.0432790953905599 4584 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3078 9116413 49.47 µM -1.71526024237895 0.0311869008043968 no 3219 0.0431487621523888 4549 17177322
SGTC_339 3091-4833 71.4 µM -1.71669838042851 0.0310769605385583 no 3220 0.0430171481162829 4414 3240077
SGTC_1262 0737-0114 49.6 µM -1.71723378026878 0.0310361132214748 no 3221 0.0429682328734494 4612 765919
SGTC_3123 9126162 49.47 µM -1.71948416003538 0.030864910247044 no 3222 0.0427631247298492 4588 25239884
SGTC_1942 st076330 65.2 µM -1.72692344409787 0.0303045038650706 no 3223 0.0420907066891337 4618 24208414
SGTC_1017 4239-0030 168 µM -1.73320668559952 0.029837775793949 no 3224 0.0415294695803251 4620 1149593
SGTC_2804 7954240 19.48 µM -1.73320950704479 0.0298375675600699 no 3225 0.0415292189294959 4601 828705
SGTC_521 r062-0005 13.8 µM -1.73386982849548 0.0297888663567169 no 3226 0.0414705911652886 4542 2832033
SGTC_2572 astragaloside iv 100 µM -1.7379949790368 0.0294861116468395 no 3227 0.0411058492463253 4564 45006101 An anti-inflammatory agent.
SGTC_1232 0279-0259 161 µM -1.74275394615347 0.0291400173763995 no 3228 0.0406883020104396 4593 1560000
SGTC_749 1000-0129 128 µM -1.74292851640292 0.0291273862574476 no 3229 0.0406730510736966 4621 708470
SGTC_3263 9137018 49.47 µM -1.74657360518516 0.0288646813804195 no 3230 0.0403556645122189 4569 43844957
SGTC_1438 4092-1045 4 µM -1.76010934438153 0.027906326403883 no 3231 0.0391946343606186 4635 1351342
SGTC_1547 harmine 94.2 µM -1.766486124674 0.0274641080442952 no 3232 0.0386571636950887 4541 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1073 triclabendazole 3.09 µM -1.78002661527729 0.0265444556645525 no 3233 0.0375358025311564 4648 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1600 coumarin 106 71.1 µM -1.78469092109081 0.0262336804952243 no 3234 0.0371557321893539 4655 100336 A hepatotoxic, DNA x-linker.
SGTC_2854 9024559 71.43 µM -1.78818468959279 0.0260028940462177 no 3235 0.0368731077921437 4604 3163529
SGTC_1827 berberine 7.24 µM -1.7883606357998 0.0259913166987359 no 3236 0.0368589214423823 4544 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2055 5235184 200 µM -1.78872571271243 0.0259673082124735 no 3237 0.0368294999280468 4617 2836034
SGTC_1914 st062367 72.6 µM -1.79567766124649 0.0255136572250994 no 3238 0.0362728983180746 4589 978205
SGTC_3159 9100096 49.47 µM -1.8059460958871 0.0248557428441226 no 3239 0.0354633799363039 4590 25236875
SGTC_3338 9144300 39.5675 µM -1.8078990774013 0.0247322365406625 no 3240 0.035311104695943 4622 4901274
SGTC_159 3970-0959 50 µM -1.81342554419105 0.0243855300772744 no 3241 0.0348831063470101 4638 6615653
SGTC_1952 st077036 64.1 µM -1.8269222754242 0.0235559212170094 no 3242 0.0338557282531487 4642 2937007
SGTC_1329 1447-1697 50.6 µM -1.82846703212103 0.0234625011948187 no 3243 0.033739744569277 4637 2840515
SGTC_2405 ticlatone 3.52 µM -1.833514083183 0.0231594481519834 no 3244 0.0333630780784706 4448 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_601 0986-0029 62.9 µM -1.83894934743506 0.0228367770370264 no 3245 0.0329613182980461 4605 24747981
SGTC_89 0302-0250 142.109 µM -1.84238706130327 0.0226346549077746 no 3246 0.0327092765149613 4690 4203518 YLR208W SEC13
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.84347583067429 0.0225709554374111 no 3247 0.0326297836914063 4651 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1802 st050112 57.9 µM -1.84787984477532 0.0223148344645466 no 3248 0.0323098634334117 4660 4662563
SGTC_1780 st038448 24.544 µM -1.84826427935306 0.0222925940033372 no 3249 0.032282060266443 4649 728868 YDL195W SEC31
SGTC_479 n-linoleoylglycine 10 µM -1.8621973723287 0.0214990606376063 no 3250 0.0312876373465152 4671 6433346 An anti-infammatory.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.86410752526513 0.0213921552432249 no 3251 0.0311533029875748 4645 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2889 9059656 51.95 µM -1.86539425163563 0.0213203947519928 no 3252 0.031063081260532 4673 3949838
SGTC_1897 st060201 15 µM -1.86637442440329 0.0212658673823188 no 3253 0.0309944993891424 4633 611878
SGTC_2315 7733312 200 µM -1.87663865173651 0.0207019149963672 no 3254 0.0302838180475812 4564 726316
SGTC_2808 7946468 45.46 µM -1.88097149517236 0.0204676834661657 no 3255 0.0299878982445636 4627 2970879
SGTC_484 loperamide 105 µM -1.8876023859785 0.0201135705771145 no 3256 0.0295396747695118 4742 3955 An opioid-receptor agonist.
SGTC_1761 st044296 37 µM -1.88968802904389 0.0200032696848995 no 3257 0.0293998480296946 4676 1826700
SGTC_1956 st077085 54 µM -1.893985536562 0.0197776098854435 no 3258 0.029113464841846 4658 24208685
SGTC_2244 6635614 200 µM -1.90594173254784 0.019161134620034 no 3259 0.0283288828975528 4631 836499
SGTC_691 1548-0686 185 µM -1.9129865929705 0.0188055996215359 no 3260 0.0278748844148153 4653 46495133
SGTC_3147 9097027 49.47 µM -1.9240875631513 0.0182567599525646 no 3261 0.0271718043618001 4669 25236841
SGTC_2364 9055074 200 µM -1.92664508724133 0.0181322667404597 no 3262 0.0270119378159715 4653 6470630
SGTC_90 0870-0863 4.608 µM -1.9608125641389 0.0165372842492898 no 3263 0.0249504459322851 4695 1738164
SGTC_1502 4534-4282 27.7 µM -1.96359433896698 0.0164128836568785 no 3264 0.0247885772143638 4687 3278949
SGTC_752 1896-0090 130 µM -1.96500282707058 0.0163502023968346 no 3265 0.0247069551695443 4694 772567
SGTC_143 4032-1194 15.74 µM -1.96746722580545 0.0162410235401488 no 3266 0.0245646853719115 4686 1806963
SGTC_2943 9068529 45.32 µM -1.9711127204135 0.0160806647294953 no 3267 0.0243554920328618 4627 3270634
SGTC_2059 5238311 157 µM -1.9741145223829 0.0159496413134464 no 3268 0.0241843612037617 4635 703021
SGTC_2202 7226349 200 µM -1.97749906910982 0.0158030104733343 no 3269 0.0239926228166571 4706 844334
SGTC_1467 k284-1082 293 µM -1.99452073008096 0.0150829757526641 no 3270 0.0230475884100489 4654 3334705
SGTC_2082 5219693 150 µM -2.00401032135396 0.0146939323250217 no 3271 0.0225344774015919 4662 2834649
SGTC_2189 6047310 154.431 µM -2.01708431321838 0.0141720991700034 no 3272 0.0218433576861694 4714 711535
SGTC_519 k048-0011 62.8 µM -2.02313004666264 0.0139362403626177 no 3273 0.0215298707350628 4682 6836379
SGTC_472 calcifediol 10 µM -2.02521891803752 0.0138555388233414 no 3274 0.0214224449702126 4725 5283731 A vitamin D metabolite.
SGTC_745 0469-0705 296 µM -2.02760791093474 0.0137637366908088 no 3275 0.0213001404849246 4707 3486736
SGTC_427 1354-0053 47.3 µM -2.03782449540468 0.0133770383495227 no 3276 0.0207837438648437 4691 6813657
SGTC_2945 9067681 61.76 µM -2.03937956238988 0.0133190094421187 no 3277 0.0207060802733467 4716 16456930
SGTC_2071 5230951 39.92 µM -2.07559650784682 0.0120277177367573 no 3278 0.018965642348974 4723 1799272
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.08017006382608 0.0118726348409094 no 3279 0.0187549685041496 4668 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_149 3970-0822 46.1 µM -2.08558306156869 0.0116913317808625 no 3280 0.0185082034997649 4687 3114250 YBL034C STU1
SGTC_2313 7726885 200 µM -2.09059118241314 0.0115257349061547 no 3281 0.0182823634269105 4694 726423
SGTC_265 mycophenolic acid 32.932 µM -2.09670981563886 0.0113261859983508 no 3282 0.0180096355364396 4732 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1188 1403-0014 4.57 µM -2.10525182547449 0.0110526276505404 no 3283 0.0176346965742714 4732 9614867
SGTC_2580 diallyl disulphide 81.36 µM -2.10563336524641 0.0110405440599938 no 3284 0.0176181060397505 4677 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_88 0180-0332 8.668 µM -2.10725424155007 0.0109893379619904 no 3285 0.0175477737290586 4740 3101745
SGTC_500 h-89 112 µM -2.1089683159634 0.0109354124844305 no 3286 0.0174736582933449 4682 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3233 9132340 49.47 µM -2.1210797540267 0.0105609013839177 no 3287 0.0169575457026996 4720 17682950
SGTC_194 1486-1323 56.904 µM -2.12519980856878 0.0104360730100164 no 3288 0.0167849720076507 4763 5178754
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.12654926342141 0.0103954680970193 no 3289 0.016728775959353 4719 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2291 7917025 104.35 µM -2.12779397834752 0.0103581369605099 no 3290 0.016677084428766 4644 2964612
SGTC_1170 0310-0127 64.8 µM -2.1314797454642 0.0102482790823232 no 3291 0.0165248196696538 4714 774975
SGTC_820 1582-0060 59.9 µM -2.1468693109677 0.00980048455490626 no 3292 0.0159018437170647 4724 3848840
SGTC_1025 k007-0731 70 µM -2.16752807139032 0.00922629207635324 no 3293 0.0150973058142136 4698 6256118
SGTC_2331 7980721 200 µM -2.17045484338277 0.00914737350648983 no 3294 0.0149862029803644 4686 2981221
SGTC_2502 avocadyne acetate 18.59 µM -2.18346107591706 0.00880377415659 no 3295 0.0145009362061199 4706 3952079
SGTC_1071 trifluoperazine 6.31 µM -2.19295327286595 0.00856020114570597 no 3296 0.0141553729417903 4740 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1770 st043884 66.3 µM -2.19662613719171 0.00846755262632889 no 3297 0.0140235789817208 4731 670149
SGTC_1339 1486-1321 22.7 µM -2.2096888610649 0.00814513615726404 no 3298 0.0135633816723262 4744 3469382
SGTC_2932 9016711 44.54 µM -2.23118061281624 0.00763811440100826 no 3299 0.0128345838222869 4703 7117328
SGTC_544 k015-0020 52.4 µM -2.24225154650041 0.00738794327468966 no 3300 0.012472559693301 4745 3008304
SGTC_1838 st055369 84.5 µM -2.25237688567576 0.00716549137858993 no 3301 0.0121492325732187 4727 676036
SGTC_2005 4024620 188 µM -2.26760953022135 0.00684196078824062 no 3302 0.0116765081520678 4700 236743
SGTC_1074 carmofur 3.8 µM -2.27270423226856 0.00673666949914895 no 3303 0.0115220047230038 4768 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2397 5161689 200 µM -2.2920663835519 0.00634946078864816 no 3304 0.0109509064260661 4720 2259942
SGTC_2072 5231554 129 µM -2.2929060083578 0.0063331247066301 no 3305 0.0109267084197802 4770 789545
SGTC_95 0471-0001 561.058 µM -2.29324274278397 0.00632658352411932 no 3306 0.0109170168054677 4727 4015405
SGTC_3256 9138902 49.47 µM -2.31179192406698 0.00597537191151929 no 3307 0.010394576343031 4790 17228773
SGTC_1386 3228-0095 33.8 µM -2.32260535043403 0.00577870364943208 no 3308 0.0101001815159552 4739 870181
SGTC_2896 9052656 71.43 µM -2.32691300457001 0.00570197244984626 no 3309 0.00998494795812863 4404 6469436
SGTC_2521 angolensin 13.4 µM -2.34408516478204 0.00540500242937416 no 3310 0.009536907754157 4748 821428 A flavenoid.
SGTC_2149 5554786 194.827 µM -2.34414891001053 0.00540392614767955 no 3311 0.00953527786263921 4758 745063 YPR165W RHO1
SGTC_1002 4049-0206 172 µM -2.37089931040841 0.00496873735343101 no 3312 0.0088724322429794 4741 4662749
SGTC_607 4491-0986 66.8 µM -2.38056109249111 0.00481940259841069 no 3313 0.00864314720749581 4742 698981 YDR232W HEM1
SGTC_652 0437-0092 114 µM -2.38719860168081 0.0047191435317941 no 3314 0.00848865856991527 4740 3091274
SGTC_2173 5763948 167 µM -2.39103754444791 0.00466200957187634 no 3315 0.00840041736226638 4743 2867177
SGTC_1162 k048-0130 20.1 µM -2.39356304871127 0.00462476051604602 no 3316 0.00834280665747449 4753 6797406
SGTC_2336 9001819 198.65 µM -2.41257158666883 0.00435281810137465 no 3317 0.00792021320756832 4719 2989602
SGTC_1080 nisoldipine 24.4 µM -2.42325280346684 0.00420636251443264 no 3318 0.00769110902376318 4777 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1366 1683-0113 21.9 µM -2.44121683681464 0.00396996444826345 no 3319 0.00731893135551619 4762 708623
SGTC_736 0958-0254 92.6 µM -2.45040783525698 0.00385367719264302 no 3320 0.00713472440355887 4770 6812352
SGTC_1446 4239-0190 62 µM -2.46762555698239 0.00364401973608973 no 3321 0.00680062561867371 4763 1340085
SGTC_1120 ficusin 1.78878 µM -2.47021194826456 0.00361342576016603 no 3322 0.00675165101657129 4738 6199 A DNA cross-linker.
SGTC_2171 5739187 198.077 µM -2.48913204051431 0.00339654493805304 no 3323 0.00640276984602755 4738 2262761
SGTC_165 k038-0023 64.381 µM -2.49657025714193 0.00331453529558614 no 3324 0.0062700412435339 4740 46368543
SGTC_2112 5488546 200 µM -2.60773091361273 0.00228381263453987 no 3325 0.00455722861445344 4750 600757
SGTC_2140 5586273 200 µM -2.61466512696751 0.00223035990388471 no 3326 0.00446574878835267 4774 854421
SGTC_1093 fluphenazine 7.97 µM -2.62945217889299 0.00212014111364436 no 3327 0.00427612796531323 4784 6602611 An atypical antipsychotic.
SGTC_2241 6772625 37.8075 µM -2.65491757266962 0.00194185011265807 no 3328 0.0039663894905498 4652 2285411
SGTC_3077 9117319 49.47 µM -2.6552734768755 0.00193945782947224 no 3329 0.00396220679048751 4752 17154678
SGTC_2095 5432005 200 µM -2.69652389943508 0.00167965535131506 no 3330 0.00350336847071439 4776 783734
SGTC_1129 3453-1384 223 µM -2.7139864985847 0.0015795515932671 no 3331 0.0033239437779568 4741 1084452
SGTC_26 0302-0163 425.158 µM -2.76475956822271 0.00131860062216704 no 3332 0.00284823827961087 4799 3100915
SGTC_3356 9151811 4.48 µM -2.78522727423526 0.0012250419494572 no 3333 0.00267451081346826 4794 1859254 YPR165W RHO1
SGTC_2266 7929956 200 µM -2.81119088051445 0.00111510846108068 no 3334 0.00246792469800752 4764 2967153
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -2.85651251601311 0.000944631595953184 yes 3335 0.00214161558434206 4772 442882
SGTC_2268 7933382 153.85 µM -2.86974037608273 0.000899592843028156 yes 3336 0.00205404475772153 4770 935025 YOR257W CDC31
SGTC_1722 st034304 3.6505 µM -2.88464795814221 0.000851205600689099 yes 3337 0.00195925788290612 4759 4036148 YLR033W RSC58
SGTC_2242 6630449 61.2675 µM -2.88786239780244 0.000841090994686724 yes 3338 0.00193934755716055 4776 691249 YDR170C SEC7
SGTC_2330 7979373 200 µM -2.92236391152906 0.000739278196011204 yes 3339 0.00173692696589307 4758 1863007
SGTC_1344 1488-0097 29.1 µM -2.97265415021733 0.000611085601250627 yes 3340 0.0014761845791478 4789 747966
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.9845455729038 0.000583938840693738 yes 3341 0.00141999946121216 4771 6708514
SGTC_692 k241-0027 77.8 µM -3.02477874671942 0.000500139242211113 yes 3342 0.00124407536587998 4795 3600480
SGTC_1950 st077106 7.18 µM -3.08981179406381 0.000387873021639495 yes 3343 0.00100141682245784 4763 13831864
SGTC_952 1185-0122 232 µM -3.15984942879793 0.000293427377054911 yes 3344 0.000789253459253913 4773 678600
SGTC_2125 5246583 200 µM -3.34520778952521 0.000136541535023749 yes 3345 0.000411104734083986 4790 835267
SGTC_1258 0671-0043 57.1 µM -3.43882237292246 9.14334102840513e-05 yes 3346 0.000292125224311474 4792 4298767
SGTC_372 0155-0182 15.9 µM -3.47271884872873 7.88838275764594e-05 yes 3347 0.000257607383876778 4707 771486
SGTC_2134 5324836 1.464 µM -3.48200889364116 7.57385918090909e-05 yes 3348 0.00024883358154392 4793 699272
SGTC_903 1134-0042 114 µM -3.57840115536675 4.93711465916302e-05 yes 3349 0.000172851281286298 4804 701009
SGTC_2969 9091408 28.7 µM -3.68950573841843 2.9758377732289e-05 yes 3350 0.000112345080181136 4795 4286311
SGTC_160 3453-0671 289.699 µM -3.69357849748434 2.92034709206042e-05 yes 3351 0.0001105601049451 4788 5322268
SGTC_3158 9100007 49.47 µM -3.90785852225464 1.05637031207565e-05 yes 3352 4.655890180957e-05 4802 19297233
SGTC_1949 st076024 69.1 µM -4.04329503065801 5.4075886372422e-06 yes 3353 2.63526161257104e-05 4791 2921930
SGTC_1126 isoteolin 1.0172 µM -4.43120125589643 7.07600377670686e-07 yes 3354 4.68547875709943e-06 4805 133323
SGTC_1131 3454-3128 32.3 µM -4.55759533054864 3.51437207772559e-07 yes 3355 2.58713036965943e-06 4800 710982
SGTC_1259 0671-0132 43 µM -4.6990500327768 1.57125549012385e-07 yes 3356 1.30687210693949e-06 4810 X1259