SGTCid condition conc unit NEM1|YHR004C.score NEM1|YHR004C.strain.pval NEM1|YHR004C.strain.significant NEM1|YHR004C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_232 clozapine 119 µM 12.8022227015301 1.87282975806257e-33 yes 1 7.96623617351641e-38 13 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1547 harmine 94.2 µM 12.7563245828717 3.14064220289123e-33 yes 2 1.43723419769175e-37 2 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_221 trifluoperazine 10.304 µM 12.6975724119359 6.0709892103135e-33 yes 3 3.04962146860813e-37 33 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1130 3454-2858 15.9 µM 10.8148731879769 1.85451142459572e-24 yes 4 1.46348600237657e-27 11 715628 YIL048W NEO1 SGTC_1991 st073000 8.92 µM 10.4413076074049 6.21489491278852e-23 yes 5 8.02916573532386e-26 8 4301969 YIL048W NEO1 SGTC_3152 9099253 49.47 µM 10.2508579990297 3.55506226418098e-22 yes 6 5.86488234809102e-25 21 25236131 SGTC_733 4069-0007 56.1 µM 9.69919159904972 4.65616766281371e-20 yes 7 1.51948420746734e-22 15 5717425 YNL287W SEC21 SGTC_660 4031-1742 102 µM 9.16504868277665 4.06706561194983e-18 yes 8 2.47623073852298e-20 5 6738706 SGTC_301 4119-0100 24.5 µM 9.16374428831833 4.11046557186382e-18 yes 9 2.50635788537796e-20 16 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2006 4011487 200 µM 9.13020977113362 5.39741852443237e-18 yes 10 3.41833465213939e-20 23 45595294 SGTC_1781 st038725 66.3 µM 9.02671277588887 1.24343869582271e-17 yes 11 8.84529894035933e-20 23 4270275 YIL048W NEO1 SGTC_3341 9147222 25.867 µM 8.49593047316407 7.77006578122378e-16 yes 12 9.81767564256259e-18 1 1939759 SGTC_1844 rapamycin 4 nM 8.35124950696605 2.29966013476873e-15 yes 13 3.37722831082831e-17 52 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_64 000l-0018 272.079 µM 8.3149740720385 3.01016506607437e-15 yes 14 4.58861656367923e-17 46 6811119 SGTC_1161 k007-0610 110 µM 8.18119198508909 8.04569665192279e-15 yes 15 1.40524853774773e-16 22 5843850 SGTC_115 0527-0192 112.043 µM 7.95516059774053 4.09055384376996e-14 yes 16 8.94496481909305e-16 9 4233931 SGTC_1026 k007-1105 30.6 µM 7.91058284656946 5.60805726907944e-14 yes 17 1.28093310660416e-15 19 7066794 SGTC_535 2293-4129 48.2 µM 7.71865535641145 2.13958916052605e-13 yes 18 5.87816538275385e-15 14 396118 YIL048W NEO1 SGTC_1760 st045453 10.4495 µM 7.59807441937129 4.88266363420988e-13 yes 19 1.50284739043961e-14 60 3323419 YIL048W NEO1 SGTC_2776 terbinafine 19.92 µM 7.32731637503953 2.97534280521446e-12 yes 20 1.17403532510702e-13 17 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_649 1123-0311 367 µM 7.2227362165349 5.88024728677281e-12 yes 21 2.54758954082289e-13 19 693629 YIL048W NEO1 SGTC_2697 mebhydrolin 72.4 µM 6.84147824953318 6.50981133329542e-11 yes 22 3.91900533953984e-12 22 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1797 st048695 56.8 µM 6.78721323957914 9.07403907700019e-11 yes 23 5.71600901477019e-12 34 592262 YIL048W NEO1 SGTC_788 1182-0090 188 µM 6.75763804650883 1.08629910330797e-10 yes 24 7.01296924834775e-12 26 5715185 SGTC_1658 st012944 20 µM 6.71610900674796 1.39680985145386e-10 yes 25 9.33205967522072e-12 19 24207260 SGTC_384 k007-0144 5.16 µM 6.67088806813586 1.83360055557697e-10 yes 26 1.2713004744655e-11 18 6824886 SGTC_743 1275-0778 158 µM 6.6548915835503 2.01801264707309e-10 yes 27 1.41754479874415e-11 9 2849257 YMR203W TOM40 SGTC_108 0509-0257 621.132 µM 6.45942220089422 6.39489977190451e-10 yes 28 5.25517513761972e-11 9 536624 SGTC_15 0266-0086 27.098 µM 6.4253388499655 7.79340599340275e-10 yes 29 6.57880448007084e-11 14 1712902 YIL048W NEO1 SGTC_2385 9074692 200 µM 6.26566542319455 1.94266591181178e-09 yes 30 1.85618330013745e-10 10 17046906 SGTC_525 k781-2675 26.7 µM 6.04093297279497 6.7721790556493e-09 yes 31 7.66128130165887e-10 24 3651118 YDL195W SEC31 SGTC_3334 9142812 21.919 µM 6.02026783759254 7.57987185494549e-09 yes 32 8.70643475562939e-10 4 45283678 SGTC_288 1315-0019 35.1 µM 5.859575942049 1.79801420097493e-08 yes 33 2.3202531798033e-09 7 6811474 SGTC_3037 9091026 49.47 µM 5.70376243848777 4.06863799968609e-08 yes 34 5.85956891413201e-09 56 25236398 YIL048W NEO1 SGTC_2688 kanamycin b 96.69 µM 5.35118043675878 2.39340692225138e-07 yes 35 4.36911692000019e-08 213 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2322 7413319 38.22 µM 5.34010273237528 2.52613053209597e-07 yes 36 4.64469629630893e-08 81 1840400 SGTC_1581 himbacine 57.9 µM 5.32541121320829 2.71313908957873e-07 yes 37 5.03624538466656e-08 24 5281825 An alkaloid muscarinic receptor antagonist. SGTC_940 3232-1287 54.8 µM 5.31073013656705 2.91331349222131e-07 yes 38 5.45934545030239e-08 13 1585493 YIL048W NEO1 SGTC_2567 aureobasidin a 60 nM 5.22285807173462 4.44401137517475e-07 yes 39 8.80912134821471e-08 56 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1351 1496-0003 46.5 µM 5.06287476722717 9.42753371924763e-07 yes 40 2.06490576774633e-07 7 3891978 SGTC_2036 5160441 105 µM 4.92035575230511 1.8091882467751e-06 yes 41 4.31935238766661e-07 56 134534 YIL048W NEO1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 4.89122143802982 2.0627194699522e-06 yes 42 5.01060722151284e-07 45 6708739 YPR165W RHO1 SGTC_875 0709-0210 25.7 µM 4.88859300287503 2.08719689651627e-06 yes 43 5.07796080252318e-07 19 6251364 SGTC_1255 0566-0045 221 µM 4.66150586455684 5.65830733355572e-06 yes 44 1.56952060924573e-06 14 2788469 SGTC_1873 rapamycin 2 nM 4.53920963828937 9.50971089997701e-06 yes 45 2.82327382731628e-06 58 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_888 0916-0002 6.97 µM 4.51168988349691 1.06698267411073e-05 yes 46 3.21565861302624e-06 35 2802138 YIL048W NEO1 SGTC_842 0271-0008 11.1 µM 4.50225351507503 1.10977614149851e-05 yes 47 3.36183557176367e-06 13 1221709 SGTC_2809 7964133 12.99 µM 4.33882222048809 2.16716835556898e-05 yes 48 7.16241702620907e-06 24 1253665 SGTC_1230 0170-0365 3.77 µM 4.33705538489307 2.1826396626658e-05 yes 49 7.22021235533982e-06 53 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_45 0kpi-0036 14.9 µM 4.29196942996182 2.61477729327933e-05 yes 50 8.85476673398881e-06 16 2795021 SGTC_1621 st003705 32.4 µM 4.26813505907142 2.87482275759998e-05 yes 51 9.85569888954293e-06 19 24207032 SGTC_206 4546-0025 72.014 µM 4.26582662777376 2.90127049328763e-05 yes 52 9.95817003879091e-06 57 6620745 YIL048W NEO1 SGTC_528 3492-0019 172 µM 4.18989559334156 3.91142371127321e-05 yes 53 1.39541418333933e-05 202 2869262 SGTC_3342 9147791 14.508 µM 4.15744893287045 4.43754706689246e-05 yes 54 1.60910592021322e-05 12 1838168 SGTC_1959 st077091 55.8 µM 4.14129223007735 4.72381418917912e-05 yes 55 1.72677310816338e-05 40 821356 YKL052C ASK1 SGTC_2679 rapamycin 1 nM 4.04492402457946 6.82772399376376e-05 yes 56 2.6170047636683e-05 136 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1002 4049-0206 172 µM 4.04076465236366 6.93594618752305e-05 yes 57 2.66386019693632e-05 28 4662749 SGTC_2249 haloperidol 116.36 µM 3.96036999542584 9.37329095935761e-05 yes 58 3.74168624403532e-05 112 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_637 1181-0519 7.26 µM 3.94209995645207 0.000100297426763266 yes 59 4.03856497279806e-05 102 6252091 YGR060W ERG25 SGTC_2540 epiandrosterone 100 µM 3.91267244465123 0.000111786267097425 yes 60 4.56401555619448e-05 59 441302 A steroid. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 3.88644185510795 0.000123057568693716 yes 61 5.08621388256947e-05 46 676296 Flavone; oxidizing agent. SGTC_1044 1222-0021 1.78 µM 3.86539194804715 0.000132864731465976 yes 62 5.54554715819453e-05 40 4306703 SGTC_900 1112-0045 141 µM 3.85461615354179 0.000138164263614125 yes 63 5.7955671578775e-05 25 56211 YIL048W NEO1 SGTC_3142 9086498 49.47 µM 3.8478668946778 0.000141583763714936 yes 64 5.95753782432378e-05 40 25236367 SGTC_1508 1080-0625 72.9 µM 3.82205352264179 0.000155407356444363 yes 65 6.61724772758987e-05 21 767111 SGTC_2973 9094665 17.96 µM 3.74420091341858 0.00020513833029057 yes 66 9.04844014539635e-05 37 25237061 YIL048W NEO1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 3.72723272009481 0.000217790328542578 yes 67 9.67968440780455e-05 40 5357218 A potent inhibitor of glutathione S-transferases. SGTC_352 k048-0007 5.11 µM 3.67877724153418 0.0002580451385035 yes 68 0.000117177422223091 89 6811911 SGTC_2183 6420625 130.508 µM 3.65006109917801 0.000285069775916125 yes 69 0.00013108896890767 71 2897619 SGTC_1163 k060-0048 49.9 µM 3.57832028740345 0.000364526756618891 yes 70 0.000172904760966083 34 6809982 SGTC_2147 5545932 89.7195 µM 3.57815719985767 0.000364728800695898 yes 71 0.000173012661266124 21 797404 SGTC_2257 7960413 200 µM 3.57414904290035 0.00036972719599578 yes 72 0.000175684376263535 70 2974689 YIL048W NEO1 SGTC_2691 st077356 60.2 µM 3.51977916783552 0.000444122060645754 yes 73 0.0002159531207899 48 2839272 SGTC_3 0833-0587 95.581 µM 3.50661344886491 0.000464113708496306 yes 74 0.000226923961588976 34 5382644 SGTC_2699 st077704 54.6 µM 3.50026329596018 0.000474051357054009 yes 75 0.000232399411049948 67 645852 SGTC_1884 5633444 25 µM 3.43169509096139 0.000594653182799588 yes 76 0.00029991076518566 79 5724239 SGTC_197 4544-0043 41.561 µM 3.42135722860491 0.000615120501524394 yes 77 0.00031154715132929 65 896523 SGTC_1745 st081495 74 µM 3.41983661074405 0.000618185386454343 yes 78 0.000313293789461376 102 13842402 YBL026W LSM2 SGTC_1854 st056233 32.9 µM 3.41645436206491 0.000625053121280063 yes 79 0.000317211483922205 32 5393174 SGTC_114 0364-0001 490.298 µM 3.3998672672996 0.000659765023098029 yes 80 0.000337092858365305 73 4003655 SGTC_1717 st033143 58.0435 µM 3.30498154725845 0.000894926815674311 yes 81 0.000474913266415959 75 674616 SGTC_2916 7875993 68.79 µM 3.30356923911479 0.000898947031878456 yes 82 0.000477311961753953 50 1299250 SGTC_16 erodoxin 22.806 µM 3.27832626173112 0.00097366033415252 yes 83 0.000522123119610936 94 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_813 k007-0158 173 µM 3.24516878783993 0.00108046304021206 no 84 0.000586905128561331 79 6523916 SGTC_2837 9008476 45.46 µM 3.2195142444835 0.00117035464201575 no 85 0.000642039904782042 66 2992805 SGTC_1 0258-0098 57.368 µM 3.20959265904078 0.00120691848706472 no 86 0.000664615981899814 27 6790032 YDR047W HEM12 SGTC_1124 fisetin 1.16336 µM 3.18254295482552 0.00131197899028376 no 87 0.000729939296374985 65 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.18192448441084 0.00131447602167707 no 88 0.000731499794756901 77 688788 SGTC_313 3474-0040 5.03 µM 3.15154631393686 0.0014426070266306 no 89 0.000812042019819445 118 1043375 YIL048W NEO1 SGTC_2742 clothiapine 36.27 µM 3.11840218472308 0.00159533119394795 no 90 0.000909172438808562 40 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_445 e6 berbamine 66 µM 3.10176966262262 0.001677398988138 no 91 0.000961837877296601 175 6610268 A calcium/calmodulin antagonist. SGTC_659 k018-0002 107 µM 3.06136396736697 0.00189302096052125 no 92 0.00110165542043808 52 6797879 YHR007C ERG11 SGTC_330 1488-0319 80.1 µM 3.04969835715121 0.00195979957437115 no 93 0.00114535654729231 45 6846614 SGTC_562 3772-2733 112 µM 3.04810083952684 0.00196910910266549 no 94 0.00115146317192475 134 2876874 YIL048W NEO1 SGTC_3219 9131112 49.47 µM 3.04431513843007 0.00199133082093409 no 95 0.00116605353480075 72 17612988 YMR079W SEC14 SGTC_69 0096-0274 206.684 µM 3.03560528799937 0.00204332389520641 no 96 0.00120026696850201 103 6741392 SGTC_1293 1000-1278 195 µM 3.03005760985803 0.00207707966965546 no 97 0.00122253547570224 52 678847 SGTC_1071 trifluoperazine 6.31 µM 3.01415390439626 0.00217667127480531 no 98 0.0012884852186673 63 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2757 clomiphene 4.22 µM 3.00753909930253 0.00221935410647987 no 99 0.00131686121118464 94 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2896 9052656 71.43 µM 3.00127865295583 0.00226044755240057 no 100 0.0013442420920123 209 6469436 SGTC_805 3852-0218 479 µM 2.98832343973603 0.00234768203317887 no 101 0.00140256261710634 123 6615355 SGTC_834 0312-0008 75.7 µM 2.98477366259008 0.00237211077816634 no 102 0.00141894111884502 89 6385573 YIL048W NEO1 SGTC_1962 st076595 64.5 µM 2.98213097749056 0.00239044627192652 no 103 0.00143124753365072 88 279619 SGTC_1450 4112-4260 37.6 µM 2.92062323181132 0.0028550912117505 no 104 0.00174666005211125 71 1633175 SGTC_2775 cyproheptadine 69.59 µM 2.91121424839845 0.0029329443715882 no 105 0.00180013526767091 51 2913 A selective serotonin reuptake inhibitor. SGTC_2806 7952793 58.44 µM 2.88024973761289 0.00320284992964538 no 106 0.00198680139439411 80 2972490 SGTC_1754 st042065 16.137 µM 2.85999931365004 0.0033912475708492 no 107 0.00211820962476273 280 1126236 YIL048W NEO1 SGTC_1279 0874-0590 65.2 µM 2.78930564865541 0.00412948683328805 no 108 0.00264105944301472 89 3523074 SGTC_2938 9059746 27.26 µM 2.77147256455291 0.0043370948711402 no 109 0.00279016873278147 103 6471769 SGTC_2773 thioridazine 9.09 µM 2.76199498182384 0.00445118447646167 no 110 0.00287246807078627 67 5452 An antipsychotic. SGTC_2012 4023501 200 µM 2.75931214171892 0.00448396323224821 no 111 0.00289615896257254 98 3477460 SGTC_2736 butenafine 14.65 µM 2.75507596871512 0.00453615955323822 no 112 0.00293392546087814 94 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_65 0798-0905 34.986 µM 2.7520006472611 0.00457439151618603 no 113 0.00296162019154374 187 3602145 SGTC_3218 9131285 49.47 µM 2.74658656690815 0.00464239802213764 no 114 0.00301094958501718 127 17156417 SGTC_1103 duloxetine 36.1 µM 2.74655141350643 0.00464284251782947 no 115 0.00301127228321942 107 60835 A selective serotonin reuptake inhibitor. SGTC_1220 1838-0075 193 µM 2.71574599901274 0.00504727205764106 no 116 0.00330633146752046 77 5529645 SGTC_3126 9127922 49.47 µM 2.67656002513612 0.00560689399211525 no 117 0.00371911203287664 120 45595682 SGTC_553 k007-0256 45.7 µM 2.6724560526019 0.00566857888663134 no 118 0.00376491183882621 109 6287000 SGTC_832 4083-0019 164 µM 2.66576067344273 0.00577050794699812 no 119 0.00384071773447013 248 1990758 SGTC_1174 0739-0097 51.1 µM 2.64663080701766 0.00607075567092589 no 120 0.00406490281662168 115 728447 SGTC_2829 7992743 58.44 µM 2.62983951487282 0.00634562393559265 no 121 0.0042712592244935 136 16462845 SGTC_964 1287-0107 19.4 µM 2.6267659770786 0.00639711277126155 no 122 0.0043100297646164 134 51516812 YPR165W RHO1 SGTC_887 0885-0007 9.62 µM 2.62168659022743 0.00648301486749071 no 123 0.00437479259513443 116 5719458 SGTC_835 0312-0010 67.2 µM 2.62124650167309 0.00649050541905234 no 124 0.00438044450803836 70 1626196 SGTC_2409 alverine citrate 63.97 µM 2.6101919399143 0.00668118860654836 no 125 0.00452457169352107 144 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3336 9143619 71.43 µM 2.60502538532909 0.00677199359141703 no 126 0.00459337265840832 95 45595730 SGTC_1138 3761-0006 1.03 µM 2.59823201142613 0.00689304937652748 no 127 0.00468525782488806 50 12061087 SGTC_439 amiodarone 34.4 µM 2.58517427629021 0.00713111118107103 no 128 0.00486648936775159 200 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1649 st011737 51.3 µM 2.56246885514533 0.00756237307439176 no 129 0.00519654543659001 77 1761035 SGTC_526 4469-0568 170 µM 2.56015400507447 0.00760760546231783 no 130 0.00523128936335791 122 2901964 SGTC_2369 9071472 200 µM 2.54816852453558 0.00784563321663289 no 131 0.00541450721416176 109 17296037 SGTC_2766 oltipraz 83.91 µM 2.53973093403191 0.00801710721026129 no 132 0.00554688894463812 120 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.52643175228886 0.00829407330717858 no 133 0.00576138870619699 145 1273210 SGTC_208 k072-0098 12.366 µM 2.52141695246536 0.00840067196298847 no 134 0.00584416310411447 173 5948901 SGTC_2570 licareol 100 µM 2.51836490333553 0.00846613589339336 no 135 0.00589505516256526 135 443158 SGTC_102 gallobenzophenone 83.616 µM 2.51137036531983 0.00861785419714417 no 136 0.0060131723861609 132 70837 SGTC_1176 0848-0131 83.3 µM 2.50981381958092 0.00865193980580975 no 137 0.00603974151707665 123 6769040 SGTC_38 0929-0051 58.268 µM 2.50818366515373 0.00868776401705442 no 138 0.00606767859427484 131 1379719 SGTC_2576 guaiol 23.12 µM 2.4990128805438 0.00889173502779225 no 139 0.00622698921656084 132 227829 SGTC_1004 4084-0029 199 µM 2.49781425340784 0.0089187018409533 no 140 0.00624808258569948 117 716894 YLR208W SEC13 SGTC_3314 9135860 59.4275 µM 2.49767609799807 0.00892181467388922 no 141 0.00625051789847665 95 25252478 SGTC_2485 5633444 17.78 µM 2.47695713903166 0.00939955231620396 no 142 0.00662539067553643 158 5724239 SGTC_608 k048-0125 159 µM 2.47275839543348 0.00949904867505432 no 143 0.00670373749418063 106 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1126 isoteolin 1.0172 µM 2.47181325150505 0.00952157202652397 no 144 0.00672148598133822 145 133323 SGTC_1600 coumarin 106 71.1 µM 2.45710585730637 0.00987812246404018 no 145 0.00700307043011326 132 100336 A hepatotoxic, DNA x-linker. SGTC_1501 4491-0275 38.4 µM 2.45336087971346 0.00997075323604118 no 146 0.00707641363574748 85 5104718 SGTC_1809 st050081 57.6 µM 2.42462024224425 0.0107072284139549 no 147 0.00766220379580959 129 5036894 SGTC_1728 st035614 33.7865 µM 2.41407143637609 0.0109891876656083 no 148 0.00788768454106253 200 15945546 SGTC_559 1550-0661 158 µM 2.4124114818261 0.0110341398301451 no 149 0.00792369251283626 105 5830875 SGTC_373 0844-0104 25.9 µM 2.39995678807328 0.0113765488293881 no 150 0.00819850368557954 179 5375804 SGTC_793 0488-0545 106 µM 2.39566974762 0.011496527029881 no 151 0.00829501524355681 136 292548 SGTC_2970 9090938 41.86 µM 2.39298020739018 0.0115723569080012 no 152 0.0083560712990073 201 17217104 SGTC_1268 0828-0275 2.46 µM 2.39114331360247 0.0116243962355186 no 153 0.00839799761359204 137 745337 SGTC_2112 5488546 200 µM 2.39049759446686 0.011642737705602 no 154 0.0084127796836188 124 600757 SGTC_2250 alverine citrate 130 µM 2.38746951734001 0.011729084936347 no 155 0.00848240478368552 353 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_365 0121-0052 13.6 µM 2.35838796254511 0.0125870568387549 no 156 0.00917724966780849 232 3101739 SGTC_1718 roemerine 11.9335 µM 2.35692093910102 0.0126317408412593 no 157 0.00921358481008761 196 235224 An aporphine alkaloid with mutagenic activity. SGTC_2831 7999036 19.48 µM 2.35648078030445 0.0126451743665814 no 158 0.00922451116328311 194 2988270 SGTC_1830 st055982 50.3 µM 2.35547753164273 0.0126758394554054 no 159 0.00924945786059454 127 455313 An antimicrobial agent. SGTC_1665 st014639 11.4 µM 2.33879382953682 0.0131953031419627 no 160 0.00967305311419021 157 981133 YIL048W NEO1 SGTC_2129 girgensonine 121.053 µM 2.3379893960395 0.0132208081875834 no 161 0.00969389911702968 171 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1254 0550-0035 264 µM 2.31888903338015 0.0138390318629454 no 162 0.0102005269570216 149 15121435 SGTC_2380 9035439 200 µM 2.31449107499766 0.0139848616724309 no 163 0.0103204001298682 160 6462575 SGTC_1987 st072290 61.9 µM 2.30883443508557 0.0141743736246627 no 164 0.0104763851926609 128 54697379 SGTC_2858 9025781 8.96 µM 2.30546148389251 0.0142884258893753 no 165 0.0105703707408316 283 4894980 YPL153C RAD53 SGTC_188 3229-0966 278.469 µM 2.27694841737872 0.0152845386467372 no 166 0.0113946530533824 181 5722370 SGTC_2196 6573537 42.6665 µM 2.27652171755811 0.0152998874366425 no 167 0.011407401137367 99 2903087 SGTC_1834 st055981 52.8 µM 2.26441212529959 0.0157410327304155 no 168 0.0117743894491439 166 471719 YDL150W RPC53 SGTC_145 3737-0113 38.366 µM 2.25269372870878 0.0161782702199384 no 169 0.0121392333209606 254 6849351 SGTC_157 1348-1695 65.819 µM 2.22870805763837 0.0171057504497715 no 170 0.0129166678942207 246 5380510 SGTC_1430 4049-0248 69.1 µM 2.21451491947691 0.0176756898757603 no 171 0.0133966887704893 176 22774488 SGTC_542 3381-0244 89.3 µM 2.19314205744455 0.0185644755963387 no 172 0.0141485728302783 200 1112843 SGTC_1226 3909-7979 35.4 µM 2.1871423524537 0.0188207090879338 no 173 0.0143660668383737 198 6615510 SGTC_2983 9022671 12.99 µM 2.18508734976923 0.0189091625661439 no 174 0.0144412213007387 155 6405161 SGTC_2289 7946404 165.07 µM 2.18425336550838 0.0189451604960258 no 175 0.0144718177455833 266 1246120 YPR165W RHO1 SGTC_945 3381-0768 11.3 µM 2.17209261096732 0.0194767221702288 no 176 0.0149243391028532 186 1126236 YIL048W NEO1 SGTC_164 4100-3994 89.624 µM 2.16605265484009 0.0197454110994862 no 177 0.0151535817603248 224 4615967 SGTC_1679 SEC14.276 6.7 µM 2.15334021133911 0.0203212200516594 no 178 0.0156459753593599 240 1005053 YMR079W SEC14 SGTC_311 1315-0136 58 µM 2.14324832779294 0.0207884082772732 no 179 0.0160465817773679 143 6759207 SGTC_524 r073-0010 27.8 µM 2.14179444437024 0.0208564572862607 no 180 0.0161050133467873 198 2772106 SGTC_2435 5706476 10.6 µM 2.13577178657523 0.0211403597103776 no 181 0.0163490099237816 208 5725375 SGTC_1091 telmisartan 47.6 µM 2.13396078919252 0.021226365140189 no 182 0.016422995335295 173 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1606 st000094 49.2 µM 2.13211024527719 0.0213145541812706 no 183 0.0164988922927653 189 1242210 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 2.12982157735486 0.021424050710991 no 184 0.0165931732862887 75 4000243 SGTC_447 ml7 120 µM 2.12921363060002 0.0214532164611796 no 185 0.0166182948405278 188 4216 Selective myosin light chain kinase inhibitor. SGTC_234 nsc-17383 10.7 µM 2.12657625533919 0.0215801313215139 no 186 0.0167276535648391 199 408974 SGTC_2525 harmine 47.85 µM 2.12044811133025 0.021877479562042 no 187 0.0169841365102809 128 5280953 A monoamine oxidase inhibitor SGTC_994 3910-0338 138 µM 2.10734098967327 0.0225250876074757 no 188 0.017544016361362 218 3479481 SGTC_2443 5493264 126.67 µM 2.1032032454796 0.022732856165609 no 189 0.0177240033581558 173 5340055 SGTC_960 1222-0186 7.7 µM 2.10224747914057 0.0227810770126058 no 190 0.0177658013413871 201 3126296 SGTC_568 1193-0097 7.48 µM 2.1007124125052 0.0228587054153521 no 191 0.0178331095291965 340 3646150 SGTC_623 k072-0108 16.9 µM 2.09921043923422 0.0229348758794659 no 192 0.0178991770874759 196 5382803 SGTC_1188 1403-0014 4.57 µM 2.09108228570564 0.0233508026079043 no 193 0.0182603441816884 273 9614867 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.07685453769193 0.0240941322385284 no 194 0.0189074934098135 179 16623 A steroid. SGTC_1678 st019265 80.2 µM 2.07493767319227 0.0241957823093784 no 195 0.0189961557931016 231 5367020 SGTC_561 1550-0330 72.9 µM 2.06912826326606 0.0245060539828219 no 196 0.0192670260827007 168 6812934 SGTC_3042 9091578 49.47 µM 2.06561241867545 0.0246954468960928 no 197 0.0194325454394047 125 25236497 SGTC_958 1222-0007 33 µM 2.06135435941218 0.0249264644404034 no 198 0.0196346228496614 228 7312461 SGTC_3316 9136639 10.545 µM 2.06078497793121 0.024957492691732 no 199 0.0196617791227221 171 4903665 SGTC_96 0929-0093 37.281 µM 2.05456041612478 0.0252988152335639 no 200 0.0199607411451359 183 6991579 SGTC_426 0988-0037 14.6 µM 2.04783999955529 0.0256717097602323 no 201 0.0202878397853329 252 5383008 SGTC_1394 3474-0001 65.7 µM 2.03788191322881 0.0262327041708387 no 202 0.020780871908627 186 5017666 YIL048W NEO1 SGTC_425 3825-7017 13.1 µM 2.03714732642751 0.026274490359981 no 203 0.02081764023546 240 3397440 SGTC_1511 0906-3109 28.5 µM 2.02562186427251 0.0269374224158753 no 204 0.0214017746110736 314 2882180 SGTC_2658 polymyxin b sulfate 77.05 µM 2.02253194742822 0.027117505911988 no 205 0.0215607132957188 218 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2363 9053361 176 µM 2.02048053065022 0.0272376185670437 no 206 0.0216667838220275 238 6469797 YMR079W SEC14 SGTC_978 1416-0512 87.4 µM 2.01889521065014 0.0273307444839235 no 207 0.0217490560663314 245 6814003 SGTC_1261 0712-0010 12.7 µM 2.01385309276197 0.0276286990093175 no 208 0.0220124797875925 245 2840123 SGTC_1764 st044502 93.5 µM 2.00360191227525 0.0282428248721116 no 209 0.0225563604288836 237 8407 SGTC_1491 4138-0063 26.5 µM 2.00340155776392 0.0282549399744864 no 210 0.022567102202588 147 23883227 SGTC_731 3966-0296 387 µM 1.99995847116278 0.0284638144698635 no 211 0.0227523742233561 208 660956 SGTC_3204 9114183 49.47 µM 1.99964682227372 0.0284827838570111 no 212 0.0227692070906981 222 17027248 SGTC_2790 5423970 71.43 µM 1.99621836291658 0.0286921618164341 no 213 0.0229550797630409 285 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2221 6807166 181.081 µM 1.98821432169709 0.0291859587365915 no 214 0.0233939958549326 119 674925 SGTC_1318 1280-3875 124 µM 1.98475680403268 0.0294014377860799 no 215 0.0235857677580251 258 373245 SGTC_576 1073-0113 22.7 µM 1.98322100210559 0.0294975746798209 no 216 0.0236713744727648 351 5439563 SGTC_3071 9117417 49.47 µM 1.98033958561654 0.0296786473521749 no 217 0.0238326917677151 157 45595590 YGL055W OLE1 SGTC_2175 5807670 165.306 µM 1.98013693566523 0.0296914168294169 no 218 0.0238440719085032 207 241186 SGTC_951 1171-0579 82.7 µM 1.97997914638602 0.0297013626807789 no 219 0.0238529359872506 330 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_694 1315-0438 43.2 µM 1.97726034452133 0.0298731701752912 no 220 0.0240061048341418 181 6793154 SGTC_1416 3966-0321 25.3 µM 1.97303260653968 0.030141967901946 no 221 0.0242459237689784 239 582530 YLR208W SEC13 SGTC_1540 guanosine 70.6 µM 1.96722496604515 0.0305144812617488 no 222 0.0245786404949452 183 6802 Guanosine is a purine nucleoside SGTC_39 0986-0283 58.349 µM 1.96120950761868 0.030904336957146 no 223 0.0249272941157312 275 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1236 0330-0013 258 µM 1.95757659331748 0.0311417726985303 no 224 0.0251398580707718 192 4617066 SGTC_914 3820-6779 408 µM 1.95541214517172 0.0312839501512365 no 225 0.02526722187866 233 2893481 SGTC_1399 3562-5772 25 µM 1.95255340029424 0.0314725566261747 no 226 0.0254362687533985 182 23847490 SGTC_1923 st058458 19.1 µM 1.9518807435946 0.0315170716830585 no 227 0.025476182503027 285 3534982 SGTC_3311 9131146 2.8755 µM 1.94754260466412 0.031805412686405 no 228 0.0257348585706137 327 4900406 YPR165W RHO1 SGTC_139 0099-0334 718.624 µM 1.90795160423875 0.0345388825282546 no 229 0.0281987358070615 309 97690 SGTC_1151 3909-8316 15.3 µM 1.90410475780705 0.0348144687375174 no 230 0.0284482710999869 259 800431 SGTC_1498 4478-3555 97.6 µM 1.90348135164917 0.0348592987855658 no 231 0.0284888823757769 167 3437919 SGTC_1171 0368-0077 21.4 µM 1.90334463320913 0.0348691367420544 no 232 0.0284977952305203 220 3239779 SGTC_602 3130-1533 38.1 µM 1.90093221104875 0.0350431045608945 no 233 0.0286554461755988 279 720941 SGTC_795 0685-0265 78 µM 1.89457151841099 0.035505212451411 no 234 0.0290745955413525 276 302754 SGTC_281 1672-3440 14.9 µM 1.88624682917391 0.0361175420132645 no 235 0.0296308503405977 234 6833000 SGTC_3118 9124250 49.47 µM 1.8854213548168 0.0361787289131673 no 236 0.0296864865716979 213 1504786 SGTC_2597 laccaic acid a 100 µM 1.87067839293003 0.0372858927391535 no 237 0.0306948357301381 301 5491415 A textile dye. SGTC_2187 6125751 200 µM 1.86466506365526 0.0377453577833951 no 238 0.031114183344019 255 874498 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.864592636861 0.0377509197921463 no 239 0.0311192628672759 158 88881 An O-methylated flavonoid and antioxidant. SGTC_3154 9100113 49.47 µM 1.86363790584079 0.0378243008200833 no 240 0.0311862853639927 266 25237525 SGTC_848 0368-0089 85.6 µM 1.8591988617978 0.0381670179639259 no 241 0.0314994780518782 266 762535 SGTC_263 alizarin 107.927 µM 1.85636222985579 0.0383873438326628 no 242 0.0317009722730439 359 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2342 7990637 118.86 µM 1.85148683191799 0.0387684456928941 no 243 0.0320497737078848 293 2033102 YER133W GLC7 SGTC_1619 st003326 88.7 µM 1.85122241283593 0.0387892026950648 no 244 0.0320687813246566 208 2849032 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.84055630386364 0.0396340724891623 no 245 0.0328433030607819 334 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_357 1325-0123 420 µM 1.83865354203487 0.0397863530611324 no 246 0.0329830803540986 226 1098503 SGTC_592 k241-0073 46.5 µM 1.837472680879 0.0398810979189897 no 247 0.033070072935915 272 4230158 SGTC_2902 5787006 60.46 µM 1.83655271136307 0.0399550374957713 no 248 0.0331379768896942 279 591003 SGTC_2753 fluvastatin 17.09 µM 1.83472919802184 0.0401019257526371 no 249 0.0332729119009368 302 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2073 5212005 126 µM 1.82584274246196 0.0408240412563082 no 250 0.0339369764663781 175 691789 SGTC_1284 0929-0043 16 µM 1.82580999378929 0.0408267218037954 no 251 0.0339394437133324 288 1239883 SGTC_3039 9090270 49.47 µM 1.81001029670447 0.0421367089021988 no 252 0.0351470952067192 220 17173750 SGTC_2675 theaflavin digallate 100 µM 1.80981924009402 0.042152755562311 no 253 0.0351619116190815 283 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_370 0180-0345 38.7 µM 1.80656214145516 0.042427077689995 no 254 0.0354152884353142 241 3989527 SGTC_1660 st012960 28.1 µM 1.79602613214913 0.0433243538491123 no 255 0.0362451805350354 314 24207266 SGTC_395 anisomycin 6.25 µM 1.7877968844811 0.0440357855027432 no 256 0.0369043918576067 222 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2792 7535235 81.82 µM 1.78503212157066 0.0442769070891278 no 257 0.0371280534005082 278 1281891 SGTC_1468 k284-1086 134 µM 1.78438619384394 0.0443333930632949 no 258 0.037180466457282 367 15996457 SGTC_1402 3909-7673 35.9 µM 1.78425987987423 0.0443444459265573 no 259 0.0371907231223925 291 5328014 SGTC_2933 9026794 32.47 µM 1.78283494949751 0.0444692856338244 no 260 0.0373065873662482 326 17586027 SGTC_800 3448-7362 155 µM 1.78168255468959 0.0445704551747105 no 261 0.0374005066711666 590 15991913 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.77760197403892 0.0449301836539152 no 262 0.0377346246796534 324 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2167 5876490 200 µM 1.77178893535773 0.0454466713888373 no 263 0.0382147999754285 311 686534 SGTC_1483 3453-0561 55.9 µM 1.7714034713647 0.0454810879287315 no 264 0.0382468158772568 325 4546991 SGTC_459 nigericin 15.3 µM 1.76999977880594 0.0456065951967984 no 265 0.0383635887868324 355 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_235 0330-0087 5 mM 1.76396768579526 0.0461491106516119 no 266 0.0388687099150063 332 46494818 YHR062C RPP1 SGTC_3007 9078383 71.4286 µM 1.75647920588434 0.0468298089687485 no 267 0.0395033094757042 292 6496995 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.75211166129903 0.047230519785725 no 268 0.039877304739721 321 5282309 SGTC_2312 7706453 155.7 µM 1.75112851638316 0.0473210986449084 no 269 0.039961887597013 319 976098 SGTC_1615 st002656 86.5 µM 1.74410461476975 0.0479722796688899 no 270 0.0405704247621847 294 1584458 SGTC_2295 7971645 200 µM 1.7417191378701 0.0481950602174616 no 271 0.0407788010219884 325 2978226 YKL099C UTP11 SGTC_3265 9137266 49.47 µM 1.7408822153033 0.0482734165854366 no 272 0.0408521133702299 244 17224265 SGTC_3095 9117207 49.47 µM 1.73863955465696 0.0484838868300157 no 273 0.0410490921786749 221 17015229 SGTC_607 4491-0986 66.8 µM 1.73257221032235 0.0490569772490746 no 274 0.041585866069229 310 698981 YDR232W HEM1 SGTC_1977 st070720 65.3 µM 1.73231132581514 0.0490817398906041 no 275 0.0416090732568255 270 682188 SGTC_860 0443-0016 25.1 µM 1.72843517668732 0.0494508337699069 no 276 0.04195511671465 310 5337942 SGTC_449 xestospongin c 11.1929 µM 1.72642001352894 0.0496435947036028 no 277 0.0421359389090983 344 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_791 1348-1292 225 µM 1.72495943343659 0.0497836812605997 no 278 0.0422673917405474 400 5437054 SGTC_374 0880-0231 82.3 µM 1.71592966029697 0.0506567555771115 no 279 0.0430874586460935 326 6833587 SGTC_2074 5212007 75.395 µM 1.71277258592204 0.0509648696494001 no 280 0.0433771926958526 251 758611 SGTC_1238 0333-0287 48.8 µM 1.7100088835986 0.0512358155232029 no 281 0.043632115160443 320 7226 SGTC_2505 galangin 7.89 µM 1.70553978445603 0.0516763775433354 no 282 0.0440468994524972 238 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2504 purpurogallin 52.29 µM 1.70428585385483 0.0518005290540255 no 283 0.0441638482380869 297 5281571 An antioxidant. SGTC_1348 1493-0373 93.8 µM 1.70109916046166 0.0521171100616167 no 284 0.0444621842737739 294 3010129 SGTC_427 1354-0053 47.3 µM 1.69978032466149 0.0522485781803425 no 285 0.0445861268795343 338 6813657 SGTC_2937 9044753 11.33 µM 1.69187375626037 0.0530422751067652 no 286 0.0453350233972823 379 6465530 YGL099W LSG1 SGTC_2522 biochanin a 4.94 µM 1.68897695998215 0.0533354505251323 no 287 0.0456119226812372 294 5280373 A possible chelator. SGTC_233 rapamycin 362 pM 1.68465440465397 0.0537753087824151 no 288 0.0460276341138245 323 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_746 1095-0025 46.6 µM 1.67900902256834 0.0543540967112264 no 289 0.0465751426750445 339 6749286 SGTC_504 lovastatin 124 µM 1.67022049624313 0.0552649279950636 no 290 0.0474378731240146 274 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1018 4259-0013 28.1 µM 1.66959621640046 0.0553300833618032 no 291 0.0474996397552029 321 6801262 SGTC_1646 st011709 75.6 µM 1.6658339517361 0.0557240318747104 no 292 0.0478732458709365 278 5757843 SGTC_1427 4048-4900 550 nM 1.6613967702232 0.0561914922619489 no 293 0.0483168930220079 328 24132586 SGTC_634 1611-4317 11.2 µM 1.66071893848452 0.0562631738009643 no 294 0.0483849539964809 366 2843522 SGTC_1410 3909-8106 77.9 µM 1.65677106300047 0.056682100157411 no 295 0.048782884739052 297 1039210 SGTC_1359 1582-0056 520 nM 1.65073166350658 0.0573277176191885 no 296 0.04939668967399 380 3661189 SGTC_1895 st058434 18.3 µM 1.65052835828801 0.0573495513938402 no 297 0.0494174590613892 338 5393175 SGTC_1892 st058411 7.36 µM 1.64130748145117 0.0583467145754228 no 298 0.0503668019371602 406 3934738 SGTC_2164 5685496 200 µM 1.63529778821141 0.0590039102408606 no 299 0.050993318508064 342 759046 SGTC_2991 9074669 71.4286 µM 1.63437670302737 0.0591051476230159 no 300 0.0510898884602531 432 17333109 SGTC_1851 st056236 18.9 µM 1.63189911235457 0.0593781382389396 no 301 0.0513503705341128 345 5393171 SGTC_1288 0973-0013 65.5 µM 1.62886304621867 0.0597140105710821 no 302 0.0516710072621609 361 4315430 SGTC_1397 3532-0190 20.1 µM 1.62650769500362 0.0599756010293186 no 303 0.0519208488695008 275 5322280 SGTC_1009 4106-0057 9.87 µM 1.61846019206116 0.0608761502577795 no 304 0.0527817295627187 366 2928005 SGTC_2030 5175110 200 µM 1.61774521971356 0.0609566673231224 no 305 0.0528587581938121 346 2831986 SGTC_670 4204-0025 119 µM 1.61340626789738 0.061447088168305 no 306 0.053328136149107 396 719039 SGTC_1908 st060353 56.5 µM 1.61049388663116 0.0617779921667586 no 307 0.0536450394985279 423 4227716 SGTC_1571 st070080 73.4 µM 1.60160601007518 0.0627964347535893 no 308 0.0546213804777109 364 4315245 SGTC_2452 5863136 48.41 µM 1.6005357494035 0.0629199510958252 no 309 0.0547398913939649 365 2184096 SGTC_1107 amlodipine 47 µM 1.59776591454001 0.0632404901997647 no 310 0.055047541541962 391 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_319 1348-1596 45.5 µM 1.59681152122158 0.0633512314011927 no 311 0.0551538634937055 392 5380505 SGTC_2237 6667747 47.222 µM 1.59431305243803 0.0636418513358295 no 312 0.0554329678363589 332 729940 YDL015C TSC13 SGTC_1885 st057546 99.9 µM 1.59066822011992 0.0640676744784031 no 313 0.0558421313004255 400 702008 SGTC_1306 1185-0270 9.02 µM 1.58966839262794 0.0641848699196548 no 314 0.055954785918987 406 1548076 SGTC_1417 3966-0327 90.4 µM 1.58908297081569 0.0642535678353788 no 315 0.0560208309365465 411 651118 SGTC_1565 sinapyl alcohol 95.1 µM 1.58598162795893 0.0646184570569084 no 316 0.0563717386104447 363 5280507 A phenol propionate derived from cinnamic acid. SGTC_2463 5473429 200 µM 1.58551977283585 0.0646729341487605 no 317 0.0564241440342571 335 5399405 SGTC_2910 7948405 25.97 µM 1.5837967638337 0.064876482630051 no 318 0.0566199879906381 335 2971328 SGTC_905 2-aminofluorene 215 µM 1.58164461291881 0.0651314261918106 no 319 0.056865361705491 405 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2586 curcumin 80 µM 1.58003031355215 0.0653231656788198 no 320 0.0570499622736431 462 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.57953042779717 0.0653826286501682 no 321 0.0571072214579905 379 688798 SGTC_2193 5925765 200 µM 1.57927012099124 0.0654136095772037 no 322 0.0571370560884807 298 877370 SGTC_2880 9042983 58.44 µM 1.57278319055006 0.0661893474482677 no 323 0.0578845145912311 388 6464714 SGTC_2671 danthron 100 µM 1.57139344890575 0.0663564624420794 no 324 0.0580456433652871 375 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1927 st060202 13.8 µM 1.57038657734954 0.0664777416695562 no 325 0.0581626016284173 362 688887 SGTC_1746 st038117 42 µM 1.57005807004487 0.0665173479855144 no 326 0.0582008010920529 397 2898218 SGTC_772 k072-0172 35.3 µM 1.56967631942853 0.066563396498995 no 327 0.0582452165486204 344 5861980 SGTC_2315 7733312 200 µM 1.55770177203187 0.0680203835825442 no 328 0.0596519801271876 344 726316 SGTC_1343 1487-0095 224 µM 1.55606295103301 0.0682216859333675 no 329 0.0598465619274329 362 4560101 YGL055W OLE1 SGTC_2974 9094440 9.66 µM 1.55435671119892 0.0684317578210006 no 330 0.060049676482461 443 25236134 SGTC_3105 9121040 49.47 µM 1.55292200582237 0.0686087843984212 no 331 0.0602208844076271 185 41448907 SGTC_839 0122-0028 230 µM 1.55271239214892 0.0686346779237313 no 332 0.0602459302296706 459 759448 SGTC_278 4092-0821 23.9 µM 1.54476003621905 0.0696226078185035 no 333 0.0612021585646058 377 877900 SGTC_577 r071-0003 38.6 µM 1.54146353201137 0.0700353317180192 no 334 0.0616020059580838 536 4568517 YMR134W ERG29 SGTC_156 3474-0145 5.642 µM 1.53952407402407 0.0702790307800518 no 335 0.0618382026571425 405 2265471 SGTC_141 0443-0274 32.331 µM 1.53554732415678 0.0707807608683096 no 336 0.0623247209495892 537 1627241 SGTC_218 alverine citrate 93.75 µM 1.53345423951285 0.0710459398423545 no 337 0.0625819866880362 358 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2050 5263056 171 µM 1.5313778498445 0.0713097569082038 no 338 0.0628380175956867 469 763468 YGL055W OLE1 SGTC_740 k014-0057 261 µM 1.53095554523445 0.0713635050103644 no 339 0.0628901899439295 446 4012779 SGTC_1025 k007-0731 70 µM 1.52229098903763 0.0724731481356593 no 340 0.0639680924545997 400 6256118 SGTC_2130 NSC 7 2.4545 µM 1.51780513138297 0.0730528072481269 no 341 0.0645317655675547 433 21448 SGTC_3125 9127534 49.47 µM 1.5165795086362 0.0732117967936199 no 342 0.0646864411085206 293 1639235 SGTC_1500 4488-1866 171 µM 1.51528032161362 0.0733806181067535 no 343 0.0648507147831714 461 2900003 SGTC_1081 sertraline 6 µM 1.51334735116956 0.0736323464997226 no 344 0.06509572542839 465 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1531 st059297 52.4 µM 1.51239193170531 0.07375701316911 no 345 0.0652170931202373 419 7566702 SGTC_1169 aniline yellow 25.8 µM 1.51062258400705 0.0739883101637503 no 346 0.0654423183144123 367 6051 A DNA damaging agent. SGTC_1941 st076221 61.8 µM 1.50998358622013 0.0740719788711569 no 347 0.0655238062333339 488 2828568 SGTC_1704 st028805 70.8 µM 1.50494523134243 0.0747342216759639 no 348 0.0661690790735429 401 2876101 SGTC_331 k048-0133 24.5 µM 1.50453754370113 0.0747880052042916 no 349 0.0662215070027789 362 6813582 SGTC_1553 gossypol 38.6 µM 1.49419641086324 0.0761621384334617 no 350 0.0675621452220522 281 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_629 3448-6466 76.7 µM 1.492249245748 0.0764230148783682 no 351 0.0678169083644847 461 573744 SGTC_658 3253-0951 102 µM 1.49203076526068 0.0764523287314878 no 352 0.0678455401441749 545 1184878 SGTC_2666 tannic acid 100 µM 1.49195703036598 0.0764622237827679 no 353 0.0678552051791188 461 16134267 A thiamine antagonist. SGTC_916 4466-0038 42 nM 1.48859677570449 0.0769141968046624 no 354 0.0682967905909168 564 5722064 YGL116W CDC20 SGTC_706 4262-0057 46.9 µM 1.48856792804414 0.0769180857494573 no 355 0.0683005911631774 421 883298 SGTC_1094 duloxetine 25.4 µM 1.48337275814622 0.0776208852504474 no 356 0.0689877005491685 438 60834 A selective serotonin reuptake inhibitor. SGTC_1933 st074711 15.9 µM 1.48329327209155 0.077631675817721 no 357 0.0689982545460932 470 17250958 SGTC_2734 clemastine 41.6 µM 1.48261645604053 0.0777236025916034 no 358 0.0690881712247936 250 26987 Clemastine is a selective histamine H1 antagonist. SGTC_366 0181-0206 4.31 µM 1.47813717534616 0.0783340734186931 no 359 0.0696855327248724 464 274874 SGTC_2447 5741742 33.78 µM 1.47771638115632 0.0783916087923789 no 360 0.0697418539547261 448 1776504 SGTC_1654 st012436 41.8 µM 1.47452188065546 0.0788294396279025 no 361 0.070170565429888 376 4323132 SGTC_830 4076-0286 57.8 µM 1.47322995090253 0.0790070337425422 no 362 0.0703445207965437 609 6866659 SGTC_3050 9093513 49.47 µM 1.4666440417877 0.0799170733493658 no 363 0.0712364563147629 425 25236664 SGTC_3069 9117009 49.47 µM 1.46453987373899 0.0802094914285697 no 364 0.0715232483183873 311 41904981 SGTC_507 nimesulide 162 µM 1.46449122761251 0.0802162613749166 no 365 0.0715298891071974 449 4495 A COX2 inhibitor. SGTC_2346 9031566 143.75 µM 1.46341047254271 0.0803667784593175 no 366 0.0716775473880922 418 4771086 SGTC_1785 bathophenanthroline 24 µM 1.45425244547066 0.0816507964506202 no 367 0.072938164744964 474 72812 An iron chelator. SGTC_3271 9137798 49.47 µM 1.45399261976456 0.0816874501164719 no 368 0.0729741761734158 371 6498326 SGTC_270 tamoxifen 5.46 µM 1.45245120354722 0.0819051531391495 no 369 0.0731880939049599 482 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_491 tetrandrine 80.3 µM 1.44880084493924 0.082422457562571 no 370 0.0736966038837818 374 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_55 0767-0285 6.563 µM 1.44648636635961 0.0827517219826202 no 371 0.0740204166324232 508 3116166 SGTC_489 paxilline 115 µM 1.43187838911242 0.0848527685020646 no 372 0.0760893140142529 421 105008 A toxic potassium channel blocker. SGTC_556 4058-0063 51.5 µM 1.42905394263167 0.0852635792265743 no 373 0.0764943649299891 499 6615692 SGTC_1614 st002383 48.6 µM 1.42527343579544 0.0858157769383289 no 374 0.0770390878978605 474 1947235 SGTC_2466 5983409 37.09 µM 1.42378488630756 0.0860339340778845 no 375 0.0772543760392103 454 2879657 SGTC_1497 4476-2978 41.3 µM 1.42312678708966 0.0861305152059234 no 376 0.0773497021666352 513 1528379 SGTC_1789 tunicamycin 25 nM 1.42035347809449 0.0865384108696832 no 377 0.0777523997074602 451 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1625 st003711 30.1 µM 1.41815653199178 0.0868625593606461 no 378 0.0780725347215896 455 24207034 YER133W GLC7 SGTC_938 3126-1755 342 µM 1.41043852490409 0.088008505139387 no 379 0.0792051183065066 491 1777771 SGTC_939 1165-0479 45.3 µM 1.40439041742384 0.0889143586576874 no 380 0.0801013114070797 498 1377347 SGTC_2694 st077685 81.9 µM 1.40396649783623 0.0889781104452214 no 381 0.080164413042619 474 2838096 SGTC_2415 st077333 57.7 µM 1.40309041266114 0.0891099696495735 no 382 0.0802949398666173 560 2766255 SGTC_275 trichlorophene 5.69 µM 1.39893763932122 0.0897369807034641 no 383 0.0809158421232702 663 62616 SGTC_3337 9144342 33.5465 µM 1.39645258154444 0.0901137551686553 no 384 0.0812891252145995 474 17682949 SGTC_2351 9026858 72.31 µM 1.39520478591335 0.090303383563304 no 385 0.0814770471143279 444 1409300 SGTC_922 1866-0035 480 µM 1.39162895951388 0.0908484458097786 no 386 0.0820173923534503 579 3156169 SGTC_1183 1254-0324 198 µM 1.39000927941479 0.0910961349264399 no 387 0.08226302978578 490 5799357 SGTC_1020 4335-0961 93.3 µM 1.38759045778386 0.0914669644839444 no 388 0.082630894382547 461 669075 SGTC_291 SEC14.278 35.5 µM 1.384238820895 0.0919826515951207 no 389 0.0831426700262043 502 1068044 SGTC_396 dithiazanine 1.25 µM 1.38256558859318 0.0922409015359355 no 390 0.0833990532487306 446 10578 An antihelmenthic. SGTC_1422 4031-0024 15.5 µM 1.37966745685134 0.092689473998215 no 391 0.0838445286106881 481 782427 SGTC_1969 st069479 40.1 µM 1.37727805639264 0.0930605168909369 no 392 0.0842131484509999 421 3895485 SGTC_70 0141-0289 43.283 µM 1.3728174570716 0.0937561258395767 no 393 0.0849045511640815 726 352408 SGTC_103 0844-0104 51.839 µM 1.37200799304587 0.0938827682722435 no 394 0.0850304747773224 621 5375804 SGTC_878 0828-0289 13.7 µM 1.36779607200656 0.0945437707687703 no 395 0.0856879587922741 568 745350 YLR208W SEC13 SGTC_1942 st076330 65.2 µM 1.36648780734343 0.0947497814535729 no 396 0.0858929526139579 493 24208414 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.36501967361369 0.0949813602175087 no 397 0.0861234333320187 538 688667 SGTC_2180 6301957 200 µM 1.3642668997953 0.0951002619550172 no 398 0.0862417897597715 474 845462 SGTC_2378 9074213 121.43 µM 1.35408359322747 0.096719516169034 no 399 0.0878548549619644 537 657714 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.34700395767616 0.0978571260487773 no 400 0.0889894790242627 542 6728940 SGTC_1961 st076550 68.7 µM 1.34679208126325 0.0978913224781488 no 401 0.0890236029058039 459 1579337 SGTC_803 4488-1585 147 µM 1.34428049329131 0.0982973552189787 no 402 0.0894288504983156 492 747204 SGTC_3038 9091290 49.47 µM 1.34427486848441 0.0982982659285993 no 403 0.089429759604701 518 25236843 SGTC_2140 5586273 200 µM 1.34323343029097 0.0984669911696225 no 404 0.0895981999766267 469 854421 SGTC_3262 9137218 49.47 µM 1.34027168078313 0.0989479883011238 no 405 0.0900785174181501 334 17650664 SGTC_1010 4112-3296 15.2 µM 1.33975273449151 0.0990324434349095 no 406 0.0901628733820645 558 704384 SGTC_3252 9135871 49.47 µM 1.33286815399161 0.100157857824639 no 407 0.0912875374868739 511 17682838 SGTC_966 1300-0360 30.2 µM 1.32853400036425 0.10087112946966 no 408 0.0920008795235041 527 70588 SGTC_910 3454-3003 490 µM 1.32798534695045 0.100961684790446 no 409 0.0920914738449273 558 820824 SGTC_610 4215-0184 155 µM 1.32776631848916 0.100997852014949 no 410 0.0921276585325824 559 5605015 SGTC_1944 st076371 56.9 µM 1.3268891572563 0.101142788512219 no 411 0.0922726758043153 514 24208455 SGTC_572 0960-0087 17.7 µM 1.32279743155175 0.101820881926846 no 412 0.0929513758078804 588 6796365 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.32211713258624 0.101933943258627 no 413 0.0930645747936953 515 689007 SGTC_1916 st067606 49.2 µM 1.32125998893296 0.102076525088325 no 414 0.0932073450432602 583 19590279 SGTC_620 0109-0052 432 µM 1.32112431444195 0.102099107199801 no 415 0.0932299585118695 530 493037 SGTC_3090 9117696 49.47 µM 1.31556001092865 0.103028381978819 no 416 0.0941608814410069 495 7923821 SGTC_3182 9108849 49.47 µM 1.31082118225273 0.103824628619304 no 417 0.0949590921768164 563 17133045 SGTC_1381 2324-0066 62.1 µM 1.31070989777018 0.103843380803447 no 418 0.0949778967133421 533 10885928 SGTC_3010 9080089 71.4286 µM 1.30989383837368 0.103980967366515 no 419 0.0951158759391358 530 17027233 SGTC_1308 1187-1617 41.4 µM 1.30888083803872 0.104151941752114 no 420 0.0952873592126856 571 2882570 SGTC_569 4130-2812 160 µM 1.30785374201471 0.104325503194472 no 421 0.0954614609316841 421 743552 SGTC_3009 9080819 71.4286 µM 1.30669907849133 0.104520871502115 no 422 0.0956574658904132 536 17027216 SGTC_2950 9072895 21.46 µM 1.30511229252217 0.104789786859134 no 423 0.0959273067988854 568 17332245 SGTC_1305 1181-0477 144 µM 1.30027999223027 0.105611810436303 no 424 0.0967525114433509 526 6252086 SGTC_2583 asiatic acid 100 µM 1.29632885554426 0.106287396045899 no 425 0.0974311056460789 517 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2298 7976326 193.81 µM 1.29522645736107 0.106476445439607 no 426 0.0976210602061245 474 2235818 SGTC_2784 7567673 72.73 µM 1.2927227262876 0.10690670985278 no 427 0.0980534873455702 586 3471247 SGTC_2254 7938975 95.19 µM 1.28835512837391 0.107660278438491 no 428 0.0988111855011726 669 2969277 SGTC_1827 berberine 7.24 µM 1.28793815225015 0.10773242152566 no 429 0.0988837466436591 503 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2519 cryptotanshinone 88.04 µM 1.28301185076942 0.108587382440703 no 430 0.0997439621232503 536 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_858 0438-0351 2.77 µM 1.28145608725048 0.108858396922501 no 431 0.100016757306522 589 2799119 SGTC_179 1273-0063 6.77 µM 1.28121862278184 0.108899806047149 no 432 0.100058443365931 509 3108139 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.28105274678747 0.108928738269472 no 433 0.100087569843235 638 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2995 9067767 71.4286 µM 1.27761073076534 0.109530344846432 no 434 0.100693357524556 490 11673567 SGTC_1976 st070609 63.5 µM 1.2765720651988 0.109712353903015 no 435 0.100876684687974 587 682556 SGTC_2235 salicylic acid 500 µM 1.27625348741233 0.109768222906235 no 436 0.10093296323159 539 338 A COX inhibitor and kinase inhibitor. SGTC_2331 7980721 200 µM 1.27601745610231 0.109809628897622 no 437 0.100974674239094 563 2981221 SGTC_2311 7694451 200 µM 1.27524657734633 0.10994493904668 no 438 0.101110990013766 573 2163142 SGTC_2686 alizarin 95.37 µM 1.27293388193176 0.11035159766677 no 439 0.101520752470709 530 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_356 1634-0012 32.5 µM 1.26771739616983 0.111272808966017 no 440 0.102449445057603 606 735457 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.26769717440484 0.111276390731923 no 441 0.102453057124244 490 77254 SGTC_2914 7968218 45.32 µM 1.26719810768718 0.111364813729676 no 442 0.102542231122814 523 2977111 SGTC_2201 6605497 169.863 µM 1.26632670369824 0.111519326770733 no 443 0.102698070163012 524 670741 SGTC_60 0986-0278 202 µM 1.26516143982875 0.111726185233882 no 444 0.102906731034793 437 3110598 SGTC_558 k064-0027 21.3 µM 1.26494164756194 0.111765233660253 no 445 0.102946123187335 578 5088526 SGTC_1058 3448-5425 97.3 µM 1.26417531685286 0.111901456784224 no 446 0.103083554083255 563 7279705 SGTC_3270 9137563 49.47 µM 1.26402899021916 0.111927481334685 no 447 0.103109810901029 508 17015724 SGTC_91 0417-1751 58.384 µM 1.25492143234452 0.113555809372473 no 448 0.104753641408413 696 6795624 SGTC_272 doxorubicin 8.13 µM 1.25024649889055 0.114398163888457 no 449 0.105604757805983 642 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1429 4049-0205 9.46 µM 1.2494187562613 0.114547773355434 no 450 0.105755975874322 617 22774478 SGTC_3093 9117344 49.47 µM 1.24937500109457 0.11455568571027 no 451 0.105763973741385 542 24824913 SGTC_1221 2958-7315 257 µM 1.24601653121044 0.115164167344551 no 452 0.106379163101856 575 4562705 SGTC_339 3091-4833 71.4 µM 1.24451297411369 0.115437322515151 no 453 0.106655413679585 578 3240077 SGTC_3049 9092223 49.47 µM 1.24355390584112 0.115611799292164 no 454 0.106831894843678 557 8623917 SGTC_2057 5236571 38.335 µM 1.24206680267094 0.115882708184305 no 455 0.107105957856603 625 54684039 YBR257W POP4 SGTC_1377 2944-0135 198 µM 1.23904036002199 0.116435433389554 no 456 0.107665275889895 607 1894137 SGTC_902 1120-0002 2.07 µM 1.23849670591125 0.116534919827417 no 457 0.107765971373934 612 3280475 SGTC_3352 9151559 45.5865 µM 1.23792323021643 0.116639928814409 no 458 0.107872263909968 563 17159339 SGTC_2740 felodipine 17.08 µM 1.23760232398845 0.116698719141124 no 459 0.107931776154311 506 3333 L-type calcium channel blocker SGTC_2231 micatex 6.853 µM 1.23741369695572 0.116733285595977 no 460 0.10796676817738 546 20737 An antifungal of unknown mechanism. SGTC_1037 k284-1091 78.7 µM 1.23720334320615 0.116771842095832 no 461 0.108005800337161 528 3334711 SGTC_1035 k081-0041 55.2 µM 1.23639509046874 0.116920073652287 no 462 0.108155870079245 631 731709 SGTC_1570 verbenone 133 µM 1.23470923841291 0.117229683823879 no 463 0.10846936819187 628 29025 A natural terpanoid with antifungal properties. SGTC_1185 1319-0113 81.3 µM 1.23379966234815 0.117396970315358 no 464 0.108638782643414 537 4672763 SGTC_2886 9058944 51.95 µM 1.23312364774836 0.117521410344629 no 465 0.108764817980743 406 4949929 SGTC_1685 st024049 53.0905 µM 1.23242268236507 0.117650541877721 no 466 0.108895616110852 558 1941139 SGTC_2473 5854593 8.94 µM 1.23153838284056 0.117813590370346 no 467 0.109060785128861 560 2872951 SGTC_2028 5153890 36.43 µM 1.22697500650967 0.118657534202082 no 468 0.109915992476601 587 2830968 YPR165W RHO1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.22518310903794 0.11899009012564 no 469 0.110253118556136 690 688664 SGTC_2475 5812728 15.03 µM 1.21842950013479 0.12024939649744 no 470 0.111530400188258 627 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_722 3534-0461 190 µM 1.21823895944384 0.120285061198423 no 471 0.11156658929274 598 658262 SGTC_1818 st052136 56.3 µM 1.21818870697724 0.120294468510752 no 472 0.111576135067541 606 674169 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.21574344827212 0.120752849755103 no 473 0.112041333744104 583 140250 A respiratory chain inhibitor. SGTC_3224 9130643 49.47 µM 1.2153219534009 0.120831986048663 no 474 0.112121661017443 577 17644395 SGTC_862 0452-0056 10.2 µM 1.2139400699286 0.121091692718451 no 475 0.112385305078531 604 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.21148739486369 0.121553606917121 no 476 0.112854331385043 645 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2010 4012422 159 µM 1.21144930350336 0.121560790445802 no 477 0.112861626618471 634 952393 SGTC_2935 9038016 29.96 µM 1.20510898239635 0.122760652314286 no 478 0.114080616327715 651 6463195 SGTC_2820 7989630 71.43 µM 1.20468965860105 0.12284029825685 no 479 0.114161564871142 498 2984098 SGTC_2424 5537928 59.2 µM 1.20237261064204 0.123281049339045 no 480 0.114609598007196 666 5382802 SGTC_2278 7948257 134.34 µM 1.19978922988812 0.123773767602307 no 481 0.115110604014294 619 1247028 SGTC_2064 5220758 200 µM 1.19534727952983 0.124624183514396 no 482 0.115975687303375 675 788518 SGTC_3064 1327-0027 10 µM 1.1940053889878 0.124881891227008 no 483 0.116237930020963 445 16000455 YPR107C YTH1 SGTC_2629 bisabolol 100 µM 1.19322493883713 0.125031946434317 no 484 0.116390645071061 657 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1289 0976-0073 69.1 µM 1.19303324356172 0.125068822465216 no 485 0.116428176922992 666 3391136 SGTC_699 0375-0592 111 µM 1.19132724858349 0.125397335884231 no 486 0.116762570419498 648 762578 SGTC_2215 7188065 200 µM 1.18904943285509 0.12583689974722 no 487 0.11721010761941 572 940217 SGTC_683 panaxydol 45 µM 1.18865035841185 0.125914022054542 no 488 0.117288641285983 669 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3132 9126706 49.47 µM 1.18698180950107 0.126236831015519 no 489 0.117617397867067 595 850858 SGTC_2859 9028643 45.46 µM 1.18231911000798 0.127141965398328 no 490 0.118539552870618 586 17151580 SGTC_2290 7904846 200 µM 1.18213261576221 0.127178261790149 no 491 0.118576542325053 640 2962154 SGTC_639 0833-0042 114 µM 1.18200457512098 0.127203185838771 no 492 0.118601942755181 672 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2873 9040596 71.43 µM 1.17952504924506 0.127686513911789 no 493 0.119094584112196 637 6463863 SGTC_3277 9138724 49.47 µM 1.17919960738341 0.127750046165351 no 494 0.119159351198769 517 15943418 SGTC_1088 bifonazole 369 nM 1.17875435490901 0.127837003248415 no 495 0.119248002400512 644 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1162 k048-0130 20.1 µM 1.17857977976646 0.127871108712292 no 496 0.119282773574323 636 6797406 SGTC_2513 baicalein 25.65 µM 1.17498203931659 0.128575380951545 no 497 0.120000950744965 647 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_650 1328-0195 38 µM 1.17456526048325 0.128657140745002 no 498 0.120084344265149 657 2780821 SGTC_1743 st037606 46.3785 µM 1.17411368705056 0.128745766930616 no 499 0.12017474594697 630 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2406 ethylparaben 405.7 µM 1.16923464461165 0.129706033392532 no 500 0.121154553246509 543 8434 A possible steroid mimic. SGTC_741 4582-0002 126 µM 1.16871305044973 0.129808983426756 no 501 0.121259631081457 643 2912688 SGTC_1545 lovastatin 49.4 µM 1.16853517148548 0.129844105353861 no 502 0.121295480367573 679 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1729 st035615 45.989 µM 1.16824753491716 0.129900912671627 no 503 0.121353465698217 629 17385451 SGTC_934 2950-0684 338 µM 1.16779950607141 0.129989431229467 no 504 0.121443823703471 681 1121253 SGTC_2848 9016370 25.97 µM 1.16751880711632 0.130044911130781 no 505 0.121500458879448 716 7894410 SGTC_2359 9039622 200 µM 1.16421076339792 0.130699977866025 no 506 0.122169304688526 687 6463596 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.16400141656295 0.130741509838798 no 507 0.122211718851849 724 66535 A nucleotide analog. SGTC_143 4032-1194 15.74 µM 1.16381396017643 0.130778706742699 no 508 0.122249706730536 743 1806963 SGTC_207 4185-0010 4.486 µM 1.1633064469545 0.130879449118647 no 509 0.122352595455138 739 3761753 SGTC_1012 4112-3522 18 µM 1.16183458947453 0.131171918990875 no 510 0.1226513304476 650 3112398 SGTC_2143 5623677 140.463 µM 1.15904864901451 0.131726742841107 no 511 0.123218177765026 608 5375313 SGTC_3321 9137793 26.8275 µM 1.15088299648517 0.133362263600856 no 512 0.124890186952925 686 4904192 SGTC_1627 st003713 25.6 µM 1.15033958189736 0.133471599198143 no 513 0.125002017062787 735 16195070 YER133W GLC7 SGTC_756 0508-1999 28.3 µM 1.14711019406157 0.134122627260043 no 514 0.125668040622767 646 6753853 SGTC_2399 5884133 200 µM 1.14703820339236 0.134137165024921 no 515 0.125682916015815 637 722445 SGTC_705 1124-0212 310 µM 1.14651018599331 0.134243825718032 no 516 0.125792057512987 680 9554485 SGTC_160 3453-0671 289.699 µM 1.14636465367016 0.134273233809474 no 517 0.125822150745182 681 5322268 SGTC_1963 st076565 50.3 µM 1.14391103399271 0.134769709224567 no 518 0.126330267288273 655 4914280 SGTC_1344 1488-0097 29.1 µM 1.14361545266035 0.134829603256776 no 519 0.126391575164724 645 747966 SGTC_1686 st019653 115.5 µM 1.14276234291142 0.135002572408098 no 520 0.126568638810678 661 97252 SGTC_1832 st054113 55 µM 1.14167507562581 0.135223237811681 no 521 0.126794552369206 640 1251267 SGTC_2918 7977171 22.06 µM 1.14125114244351 0.135309343775679 no 522 0.126882713688345 649 2236483 SGTC_2220 6782180 200 µM 1.13958185372613 0.135648761850774 no 523 0.127230274450237 575 833803 SGTC_2122 5258151 111.688 µM 1.1392800853897 0.135710182891515 no 524 0.127293175926021 668 2173356 SGTC_1325 1431-0015 227 µM 1.13684976036043 0.136205538589544 no 525 0.127800548675432 638 1103340 SGTC_1612 st002233 45.4 µM 1.13561077763019 0.136458547151745 no 526 0.128059748118646 672 1035021 SGTC_2248 tofa 1.1 µM 1.13335871634026 0.136919255916254 no 527 0.128531821721439 633 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_959 1222-0044 107 µM 1.13286529641915 0.137020337636721 no 528 0.128635412740622 676 6083612 SGTC_2985 9022375 71.43 µM 1.13024399359692 0.137558191121105 no 529 0.129186713400923 687 4939335 SGTC_2348 9022543 33.42 µM 1.1298911794165 0.137630693387852 no 530 0.129261040574337 695 3162678 YDL140C RPO21 SGTC_522 1273-0010 11.6 µM 1.12845030579406 0.137927059371853 no 531 0.129564896329276 655 5705015 SGTC_2986 9022445 71.43 µM 1.12569105758407 0.138495809432892 no 532 0.130148155086722 681 6459286 SGTC_1730 st033808 45.1 µM 1.12566168835136 0.138501871749481 no 533 0.130154373006676 767 1045166 SGTC_2925 9010536 32.5 µM 1.1235178624419 0.138944882816502 no 534 0.13060880930949 749 2994177 SGTC_296 1222-0039 74.9 µM 1.12284087541394 0.139084979068567 no 535 0.1307525409044 636 5984176 SGTC_170 4197-0004 226 µM 1.1224151371114 0.139173130932562 no 536 0.130842985683857 616 218692 SGTC_1810 st050138 53 µM 1.12068750762089 0.139531237936212 no 537 0.131210450775595 652 3444541 SGTC_212 3807-4682 38.772 µM 1.11739856822878 0.140214707683941 no 538 0.13191197353203 843 3125501 YBL034C STU1 SGTC_1666 st014829 29 µM 1.11087797251237 0.141576457112794 no 539 0.133310439069478 721 3858230 SGTC_671 0560-0003 407 µM 1.11000572457436 0.141759292971834 no 540 0.133498279840398 665 3238678 SGTC_2088 5278280 127.392 µM 1.10852984933717 0.142069021971341 no 541 0.133816527680322 726 791502 SGTC_3148 9097893 49.47 µM 1.10756289890416 0.142272195570704 no 542 0.134025316921487 653 17174100 SGTC_584 0986-0246 15.4 µM 1.10656530733521 0.142482013371054 no 543 0.134240956836169 758 53315 YDR232W HEM1 SGTC_2908 7930301 100 µM 1.10424604984347 0.142970618236565 no 544 0.134743209358715 786 2223178 SGTC_2588 indole-3-carbinol 100 µM 1.10411389374714 0.142998494009716 no 545 0.134771867527728 749 3712 Induces cell cycle arrest. SGTC_462 ag-879 158 µM 1.10349610645477 0.143128853002386 no 546 0.134905890730803 739 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_590 k048-0076 22.4 µM 1.10186741904172 0.143472906231542 no 547 0.135259657431057 702 6832814 SGTC_2288 7946289 167.31 µM 1.10167150988188 0.143514328788836 no 548 0.13530225361082 765 1246052 SGTC_2965 9082772 38.63 µM 1.099526999528 0.143968286706824 no 549 0.135769131936723 744 16459634 SGTC_329 k048-0121 21.3 µM 1.09818287557194 0.144253309086673 no 550 0.136062321138821 679 6832902 SGTC_196 k015-0023 18.111 µM 1.09563521351717 0.144794585659562 no 551 0.13661922252076 730 5211998 SGTC_687 k029-0044 34.9 µM 1.08756604588793 0.146517978877406 no 552 0.138393363503354 761 5829338 SGTC_970 1315-0089 19.5 µM 1.08071360501078 0.147992274825087 no 553 0.139912264660591 689 6811083 YLR033W RSC58 SGTC_1489 4065-0444 182 µM 1.07806826308217 0.148564064948662 no 554 0.140501646778402 710 2877968 SGTC_135 0933-0004 26.348 µM 1.07771522489779 0.148640485649415 no 555 0.140580430971685 682 21230617 YGL099W LSG1 SGTC_2158 5657123 3.6195 µM 1.07740576043841 0.148707495738694 no 556 0.140649515887566 730 2858827 SGTC_2382 9035899 200 µM 1.07523806094984 0.149177446017998 no 557 0.141134079545088 739 6462679 SGTC_2269 7935389 174.42 µM 1.07459986224977 0.149315994227576 no 558 0.141276956779282 696 97605 SGTC_2433 5607874 27.82 µM 1.07355841241942 0.149542269700815 no 559 0.141510322669485 715 2252428 SGTC_417 st075190 100 µM 1.07031807402899 0.150247759984989 no 560 0.142238080817098 764 222757 SGTC_2678 equilin 100 µM 1.06900603749978 0.150534048011788 no 561 0.142533474454774 751 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1324 1418-0026 34.4 µM 1.06567406450957 0.15126272083204 no 562 0.143285502814791 752 1372513 SGTC_1518 st038567 90.8 µM 1.0656709177158 0.151263410114884 no 563 0.143286214312289 723 77966 SGTC_2336 9001819 198.65 µM 1.06170589170957 0.152133580859666 no 564 0.144184611914734 755 2989602 SGTC_759 3486-0358 89.3 µM 1.06129766077201 0.152223360217999 no 565 0.144277324246725 813 875103 SGTC_1981 st071826 47 µM 1.06127233748395 0.152228930549073 no 566 0.144283076680274 693 11838600 SGTC_643 k048-0106 28.4 µM 1.06122108239733 0.152240205478652 no 567 0.144294720249633 740 6763920 SGTC_786 4544-0069 423 µM 1.06031454613303 0.152439714038447 no 568 0.144500761898503 766 748821 YLR208W SEC13 SGTC_1049 3226-0134 66 µM 1.05919733679672 0.152685825658661 no 569 0.144754958842433 786 5702385 SGTC_2095 5432005 200 µM 1.05844298249082 0.152852152418663 no 570 0.144926766153408 702 783734 SGTC_807 1315-0151 48 µM 1.05670252003729 0.153236363330879 no 571 0.14532368726692 836 4011080 SGTC_3350 9150499 3.57 µM 1.05520880264974 0.153566614582785 no 572 0.145664919568267 805 4910996 YPR165W RHO1 SGTC_517 1365-0151 113 µM 1.05504692533832 0.153602432895401 no 573 0.145701931960198 736 768657 SGTC_3200 9114385 49.47 µM 1.05317880259775 0.154016189454702 no 574 0.146129525829479 695 17018030 YLR208W SEC13 SGTC_1211 1056-0033 32.3 µM 1.05072310510604 0.154561204339993 no 575 0.146692890530216 777 6741922 SGTC_2899 9053889 58.44 µM 1.05068382477207 0.154569932520742 no 576 0.146701913707916 735 6470052 SGTC_321 4534-3890 65.3 µM 1.04891774272857 0.154962696606714 no 577 0.147107989358858 751 699746 SGTC_679 0422-0091 41.4 µM 1.04843489187628 0.15507019383768 no 578 0.147219142429937 791 627384 YHR062C RPP1 SGTC_3313 9133968 57.047 µM 1.04816667462063 0.155129928393242 no 579 0.147280910805333 801 1494643 SGTC_3004 9076122 71.4286 µM 1.04476558580703 0.155888701016656 no 580 0.148065662009688 768 44782551 SGTC_104 0074-0074 590.992 µM 1.04419501755876 0.15601623231535 no 581 0.148197585839444 616 3943124 SGTC_990 3985-0011 41.3 µM 1.04208105006828 0.156489337667989 no 582 0.148687051737438 693 5399565 YGL099W LSG1 SGTC_398 bronopol 33.3 µM 1.04168029525409 0.156579132893141 no 583 0.148779963811311 766 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1409 3909-8004 61.9 µM 1.04007264517713 0.156939692318067 no 584 0.149153075711395 784 2119279 SGTC_3040 9091894 49.47 µM 1.03745916985537 0.157527000349797 no 585 0.149760957441071 693 25236966 SGTC_2373 9071805 200 µM 1.03701534363884 0.157626881588341 no 586 0.149864353204194 785 10149009 SGTC_1250 0485-0349 40.2 µM 1.03334445971693 0.15845459363344 no 587 0.150721364033899 718 6842794 YDL195W SEC31 SGTC_3048 9093155 49.47 µM 1.03160250567065 0.158848365601071 no 588 0.151129183057385 692 25236002 SGTC_3183 9108214 49.47 µM 1.02887651932346 0.159465865987661 no 589 0.151768851742706 680 4974831 SGTC_345 1362-0200 395 µM 1.02813746916828 0.159633548734376 no 590 0.151942583752292 725 1419823 SGTC_430 0958-0115 16.4 µM 1.0257295153281 0.160180688417454 no 591 0.152509548947722 739 6833180 SGTC_2397 5161689 200 µM 1.02530991242072 0.160276156636262 no 592 0.152608490068227 801 2259942 SGTC_390 dec-rvkr-cmk 16.7 µM 1.02418296758267 0.160532743597211 no 593 0.15287443104792 805 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_358 0075-0058 9.45 µM 1.02227067108063 0.16096875598702 no 594 0.153326405234077 851 1069125 SGTC_1267 0828-0272 9.49 µM 1.01569870740004 0.162473080886914 no 595 0.154886441878644 823 745334 SGTC_729 4092-0585 94.1 µM 1.01500702588648 0.162631937451684 no 596 0.155051239198556 735 2169061 SGTC_2489 cantharidin 73.42 µM 1.01225058429251 0.163266005035959 no 597 0.155709127819267 775 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1924 st058459 75.1 µM 1.01191433864342 0.163343461798787 no 598 0.155789506421857 765 688683 SGTC_824 1304-0008 100 µM 1.01173552163993 0.163384663388083 no 599 0.155832263278773 787 768245 SGTC_2268 7933382 153.85 µM 1.00872512577847 0.16407930818134 no 600 0.156553239160527 872 935025 YOR257W CDC31 SGTC_408 cantharidin 100 µM 1.00770280474575 0.164315642513425 no 601 0.156798579064233 798 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1791 st048313 56.1 µM 1.00650252015428 0.164593398989153 no 602 0.157086949978569 746 1204976 SGTC_1603 st002045 67.8 µM 1.00577102227858 0.164762823196839 no 603 0.157262864848121 818 5887985 SGTC_1113 artemisinin 1.17947 µM 1.0056737441238 0.164785362562091 no 604 0.157286268619061 841 2240 An anti-malaria and mitochondrial poison. SGTC_1084 voriconazole 435 nM 1.00405471799994 0.165160784419136 no 605 0.157676119962495 817 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2543 pimpinellin 60.67 µM 1.00031693903001 0.166029618079354 no 606 0.158578576117758 777 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.999559266379974 0.166206095791539 no 607 0.158761922065752 1015 16725076 SGTC_2056 5235370 200 µM 0.99806146219263 0.16655532190315 no 608 0.15912477798331 764 5511916 SGTC_372 0155-0182 15.9 µM 0.995255474917872 0.167210836135185 no 609 0.159806013536057 870 771486 SGTC_289 k017-0060 526 µM 0.991880201850229 0.168001543074194 no 610 0.160627983985591 773 5512909 SGTC_565 1418-0001 44.5 µM 0.9906853162436 0.168282038270531 no 611 0.160919631649917 864 2862145 SGTC_397 arbidol 50 µM 0.989584744776651 0.168540659905698 no 612 0.16118856474077 869 131410 A RNA synthesis inhibitor. SGTC_2756 carbadox 75.1 µM 0.988816496172595 0.168721340848165 no 613 0.16137646587006 786 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3346 9158254 43.5805 µM 0.986114886358318 0.169357708477376 no 614 0.162038369727764 809 17639500 SGTC_1447 4239-0816 81.9 µM 0.984008256623482 0.169854995351364 no 615 0.162555726634864 759 1341554 SGTC_2958 9077254 16.72 µM 0.983412981679028 0.169995684272951 no 616 0.162702111843942 770 16457351 SGTC_566 0958-0068 16.5 µM 0.982741572759712 0.170154456519915 no 617 0.162867322170536 746 6815365 SGTC_1739 st037196 92.5 µM 0.978835659426335 0.17107999571104 no 618 0.163830593581399 881 612214 SGTC_1909 st060837 51.5 µM 0.977788515548091 0.171328671627247 no 619 0.164089466121014 777 678937 SGTC_948 3448-0295 75.3 µM 0.973470973079306 0.172356441422212 no 620 0.165159639955939 858 678569 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.973191049620971 0.172423211319054 no 621 0.165229179185017 852 688669 SGTC_166 k072-0058 166.424 µM 0.969789208558964 0.173235967743011 no 622 0.166075786490381 849 5846229 SGTC_2866 9034245 58.44 µM 0.96927720875136 0.173358503895995 no 623 0.166203448777332 822 6462273 SGTC_1712 st032288 53.4 µM 0.968582152988151 0.173524938833605 no 624 0.166376855733441 931 2883011 SGTC_1780 st038448 24.544 µM 0.967847379276286 0.173700994987126 no 625 0.166560298757833 835 728868 YDL195W SEC31 SGTC_2069 5228469 200 µM 0.967837669156401 0.173703322350155 no 626 0.166562723852398 785 2835210 SGTC_3190 9110366 49.47 µM 0.967028113168897 0.173897429960446 no 627 0.166764989960928 741 17123768 SGTC_641 4092-0595 30 µM 0.966700422902196 0.17397603960775 no 628 0.166846907823025 855 786260 SGTC_2915 7971052 15.16 µM 0.966059432598494 0.174129872140384 no 629 0.167007221233265 679 5741558 SGTC_3175 9106517 49.47 µM 0.965984901577734 0.174147764596865 no 630 0.167025868087869 812 41468073 SGTC_2362 9071156 126 µM 0.965527556933399 0.174257583647833 no 631 0.167140320162232 826 653133 SGTC_1285 0929-0069 65.5 µM 0.964556946182689 0.174490795554018 no 632 0.167383386330511 830 1206237 SGTC_2493 resveratrol 26.09 µM 0.962754666759811 0.174924360808197 no 633 0.167835327804557 781 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3253 9135987 49.47 µM 0.961468837989569 0.175234103621169 no 634 0.168158243310168 790 4182430 SGTC_1767 st044992 70.3 µM 0.958899666498379 0.175854031444252 no 635 0.168804646405101 814 9600693 SGTC_1656 st012921 11 µM 0.956369736525056 0.176465846115738 no 636 0.169442734425424 789 6732821 SGTC_2238 6671620 73.2395 µM 0.956353624982574 0.176469746690554 no 637 0.169446802962825 820 729941 SGTC_500 h-89 112 µM 0.954055952161161 0.17702656746531 no 638 0.170027660443305 903 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2008 4012253 172 µM 0.953373891420984 0.177192072321782 no 639 0.17020033248882 863 603940 SGTC_2846 9008642 19.48 µM 0.951674191645739 0.177604936557933 no 640 0.170631121028468 783 2992898 SGTC_1846 st056244 14.8 µM 0.951276729734955 0.17770156923953 no 641 0.170731958275097 871 5393182 SGTC_1167 k781-0610 148 µM 0.950674195628117 0.177848123220293 no 642 0.170884895657558 879 4525169 SGTC_1077 5-fluorocytosine 377 nM 0.94988016061369 0.17804137223708 no 643 0.171086574323004 836 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2783 7738165 71.43 µM 0.949804241873405 0.17805985596349 no 644 0.171105865057923 736 17201110 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.936701887297182 0.181267958916658 no 645 0.174455962587633 867 5357218 A potent inhibitor of glutathione S-transferases. SGTC_780 0109-0199 192 µM 0.936386438978662 0.181345639812625 no 646 0.174537128782565 915 610414 SGTC_465 cgp-37157 41 µM 0.936228166055153 0.18138462324848 no 647 0.174577862113172 757 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1334 1486-0610 236 µM 0.936226085765113 0.181385135669558 no 648 0.174578397539581 861 3742339 SGTC_3202 9113761 49.47 µM 0.934623355345509 0.181780192648663 no 649 0.17499121921272 949 4798415 SGTC_3061 glucosamine 200 µM 0.932834603900983 0.182221737020359 no 650 0.175452685815407 859 91431 and experimental redox chemotherapeutic SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.930029356288772 0.182915547005441 no 651 0.176177942576913 869 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2808 7946468 45.46 µM 0.928469385708826 0.183302080235263 no 652 0.176582070511362 888 2970879 SGTC_2263 7948595 193.29 µM 0.922964086303875 0.184670262698335 no 653 0.178012960621117 822 2971371 SGTC_326 k292-0812 17.5 µM 0.922614382066407 0.184757385486855 no 654 0.178104099022195 880 3579357 SGTC_797 k781-0471 270 µM 0.922380193199195 0.184815743892438 no 655 0.178165148750993 911 23738129 SGTC_2217 6934799 96.0675 µM 0.922379296057042 0.184815967476696 no 656 0.178165382648636 891 675606 SGTC_347 4534-1311 26.2 µM 0.922091337288719 0.184887740763827 no 657 0.178240467571736 863 2862016 SGTC_728 3030-5151 22.5 µM 0.921077651803661 0.18514053812806 no 658 0.178504943551535 859 3125388 SGTC_441 propafenone 146 µM 0.920364310854201 0.185318562881415 no 659 0.178691206131226 877 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3244 9134489 49.47 µM 0.920183209334742 0.185363776347841 no 660 0.178738513559297 875 16584271 SGTC_1509 1326-1131 80 µM 0.919944042073475 0.185423496891827 no 661 0.178801001030373 870 768313 SGTC_907 3448-6986 75.5 µM 0.915700807722799 0.186485025921792 no 662 0.179911920633635 947 590582 SGTC_199 4063-0024 41.6 µM 0.915228437947092 0.186603430949182 no 663 0.180035859177585 918 306215 SGTC_1486 3970-0793 4.53 µM 0.912818529726861 0.187208226986707 no 664 0.180668995593144 922 2844330 SGTC_3026 9090633 49.47 µM 0.911637480139377 0.187505067960242 no 665 0.180979792694972 904 25236842 SGTC_506 n9-isopropylolomoucine 153 µM 0.911522970726179 0.18753386382545 no 666 0.181009944031274 915 6610355 SGTC_3114 9122766 49.47 µM 0.91002391883417 0.187911084814076 no 667 0.181404947849886 813 17176985 SGTC_1478 0453-0656 35.7 µM 0.908787785963426 0.188222497126901 no 668 0.181731077527523 926 5258496 SGTC_2300 7976697 71.57 µM 0.907074196117692 0.188654718951705 no 669 0.182183781249909 793 2236109 SGTC_486 niguldipine 82 µM 0.905809073837928 0.188974215284754 no 670 0.182518458721411 870 1236 A calcium channel blocker. SGTC_1179 1021-1431 9.29 µM 0.904945895870291 0.18919239503321 no 671 0.182747025440671 938 2840958 SGTC_2109 5483026 200 µM 0.9020231533877 0.189932308248317 no 672 0.183522284248454 906 759335 SGTC_2488 5268135 45.7 µM 0.900247511559613 0.190382692157347 no 673 0.183994273507103 949 1270356 YLR208W SEC13 SGTC_1437 4092-1038 11.6 µM 0.899669002154861 0.190529570124785 no 674 0.184148212109277 953 3977136 SGTC_1747 st037496 66.6 µM 0.896824179200498 0.191252855025601 no 675 0.184906371807408 924 723305 SGTC_1322 1348-1070 12 µM 0.895247313436889 0.191654490911454 no 676 0.185327448876544 910 6758089 SGTC_2436 5633522 8.09 µM 0.894849254323769 0.19175596023434 no 677 0.185433838310806 954 5724242 SGTC_519 k048-0011 62.8 µM 0.890292285663748 0.19291992049365 no 678 0.186654481148459 909 6836379 SGTC_277 nystatin 15.5 µM 0.888919032476246 0.193271527036123 no 679 0.187023297980047 983 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1390 3413-2614 145 µM 0.885554915545632 0.194134523671106 no 680 0.187928707565841 964 3421432 SGTC_1705 st027868 56.3335 µM 0.884124710734791 0.194502123965356 no 681 0.188314447593158 961 292948 SGTC_385 1494-0393 12.4 µM 0.882690929549918 0.194871068415021 no 682 0.188701642103867 935 3090647 SGTC_2398 5228213 48.84 µM 0.882176927971426 0.195003436260548 no 683 0.188840568321179 1006 80771 YMR134W ERG29 SGTC_3260 9137109 49.47 µM 0.881964100316297 0.195058260531589 no 684 0.188898110600937 821 17478346 SGTC_2584 androsterone 48.74 µM 0.881002903107862 0.195305981029653 no 685 0.189158124340976 1064 2754130 A steroid. SGTC_44 0929-0055 61.211 µM 0.878122089104286 0.196049570808194 no 686 0.189938733407556 872 1379590 SGTC_1998 st075797 76.8 µM 0.877925425292543 0.196100395805771 no 687 0.189992095165119 1007 24208315 SGTC_2440 5628896 157.78 µM 0.876322786188341 0.196514873189369 no 688 0.190427290546651 932 5522048 SGTC_3044 9093193 49.47 µM 0.874328151204185 0.1970314700654 no 689 0.190969786397516 957 25236277 SGTC_575 k072-0246 11.9 µM 0.873445757380778 0.197260266048386 no 690 0.191210079808603 958 6796779 SGTC_2746 daunorubicin 9.88 µM 0.872085073239522 0.197613392822763 no 691 0.19158098430621 825 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1374 2889-5571 141 µM 0.87198618625488 0.197639071005623 no 692 0.191607956757585 944 2853281 SGTC_1241 0364-0022 50.8 µM 0.870920907037763 0.197915822077802 no 693 0.191898670195606 953 4563895 SGTC_1464 k208-0027 110 µM 0.870037953379264 0.198145383744976 no 694 0.192139831725395 963 X1464 SGTC_604 1000-0114 314 µM 0.869640393880535 0.198248798850797 no 695 0.192248477843371 1005 1572745 SGTC_2929 9013348 24.6 µM 0.868857451316651 0.198452556903624 no 696 0.192462552315528 913 2995952 SGTC_894 0960-0238 55.9 µM 0.867512828396775 0.198802784987013 no 697 0.192830543000572 973 6741907 YDL195W SEC31 SGTC_3281 9140613 49.47 µM 0.866485347878317 0.199070659352973 no 698 0.193112029006128 883 16013766 SGTC_172 1112-0046 2.638 µM 0.86564797108448 0.199289132544936 no 699 0.193341620099371 857 2802135 YIL048W NEO1 SGTC_2845 9003024 42.97 µM 0.86331644313892 0.199898192841781 no 700 0.193981752972214 965 2990173 SGTC_443 clozapine 122 µM 0.86328715068384 0.199905851963457 no 701 0.193989803570803 874 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_440 fluspirilene 35.1 µM 0.860644802410533 0.200597474629764 no 702 0.194716851220211 956 3396 An atypical antipsychotic. SGTC_2375 9072683 200 µM 0.859785102155439 0.200822806669182 no 703 0.194953756492115 1057 16798029 SGTC_3018 9082602 49.47 µM 0.858980745074451 0.201033770453967 no 704 0.195175569618914 992 17332089 SGTC_2192 5915882 198.485 µM 0.858524640304958 0.201153454956221 no 705 0.195301415238167 936 2876149 SGTC_1341 1486-1360 280 µM 0.857712159114203 0.201366760493836 no 706 0.195525712140192 952 3976547 SGTC_305 1682-2595 20.8 µM 0.85583062913673 0.20186125003068 no 707 0.19604573530554 974 226033 SGTC_2022 5136654 200 µM 0.853486485512513 0.202478336277854 no 708 0.196694789489903 940 1713771 SGTC_2738 aclarubicin 5.55 µM 0.852917105913678 0.202628393205632 no 709 0.196852637428551 888 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1231 0242-0792 125 µM 0.85247124160605 0.202745944732491 no 710 0.196976297006397 955 3707635 SGTC_1811 st050069 61.5 µM 0.852072710241824 0.202851051473341 no 711 0.197086868676105 972 3877702 SGTC_2068 5226020 147 µM 0.851843193660802 0.202911597838131 no 712 0.197150564599628 1048 1810509 SGTC_3288 9119690 36.221 µM 0.851130737595514 0.203099612154879 no 713 0.197348366234049 902 17595618 YKL019W RAM2 SGTC_3291 9121177 71.43 µM 0.85030417029483 0.203317870254143 no 714 0.197577999308874 874 17015612 SGTC_648 0375-0473 33.3 µM 0.846441413062421 0.204339699272876 no 715 0.198653272040368 999 1713139 SGTC_1738 st035555 74 µM 0.845327476376128 0.204634939947303 no 716 0.19896401211489 978 5331140 SGTC_1925 st057770 10.1 µM 0.844849575346819 0.204761681835723 no 717 0.199097415540875 896 5989122 SGTC_2007 4011539 71.82 µM 0.841743972503925 0.205586441061643 no 718 0.199965639547994 958 45595301 SGTC_768 0384-0033 77.3 µM 0.841732558480244 0.205589475932484 no 719 0.199968834725232 959 3965305 YMR134W ERG29 SGTC_1975 st070967 30.8 µM 0.840507214491662 0.205915436886086 no 720 0.200312029110432 1054 261391 SGTC_224 benfluorex 43.875 µM 0.839470593470176 0.206191433767641 no 721 0.200602642102834 978 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.839206053214733 0.206261901833993 no 722 0.200676845541301 1008 688751 SGTC_2944 9067346 25.62 µM 0.838630599788189 0.206415240045309 no 723 0.200838316899994 912 6473075 SGTC_702 1488-0190 94 µM 0.838368299151207 0.206485156395358 no 724 0.200911943922936 992 949357 SGTC_2151 5563267 85.4165 µM 0.835820457888055 0.207165014285913 no 725 0.201627957839074 993 5310824 SGTC_2639 lactacystin 53 µM 0.833581318292904 0.207763590888503 no 726 0.202258478282421 996 3870 A proteasome inhibitor. SGTC_2712 st079126 47.7 µM 0.832686336526373 0.208003126809998 no 727 0.202510826213687 958 3152970 SGTC_2313 7726885 200 µM 0.830750568083214 0.208521779695551 no 728 0.203057276470229 949 726423 SGTC_1038 k292-0204 154 µM 0.830324673934638 0.208635992309541 no 729 0.203177620665664 933 4454212 SGTC_2954 9074818 52.69 µM 0.82961518214763 0.208826339551543 no 730 0.203378195083735 966 16648742 SGTC_3133 9127736 49.47 µM 0.829104556372183 0.208963396979138 no 731 0.203522622858108 1007 27243420 SGTC_1573 oleylamine 1.06 µM 0.827692302100602 0.209342736966943 no 732 0.20392238988426 990 5356789 An amine of the fatty acid oleic acid. SGTC_3343 9148379 18.9835 µM 0.826056159952826 0.209782720920085 no 733 0.204386117495604 1033 1955036 SGTC_672 1441-0018 53.7 µM 0.824453442102766 0.210214243215624 no 734 0.204840979830626 959 251141 SGTC_2619 obliquin 87.91 µM 0.823468755838287 0.210479622503787 no 735 0.205120738849223 1041 6708593 A bioactive alkalod. YER133W GLC7 SGTC_611 3453-1652 23.7 µM 0.823466514996281 0.210480226649302 no 736 0.205121375753239 1038 1560575 SGTC_1642 st009582 77.7 µM 0.823204451986693 0.210550887553253 no 737 0.205195868799045 996 6739311 SGTC_2114 5491910 81.25 µM 0.822753753649215 0.210672443368749 no 738 0.20532402020234 998 2849228 SGTC_1329 1447-1697 50.6 µM 0.82075587620487 0.211211777423789 no 739 0.205892668162251 983 2840515 SGTC_3096 9117468 49.47 µM 0.820390391999227 0.211310528636647 no 740 0.205996795483798 921 41316311 SGTC_2960 9079389 5.97 µM 0.819221314986384 0.211626586436851 no 741 0.206330077980225 1012 16457355 SGTC_876 0720-0963 56.8 µM 0.816567083825997 0.212345179363664 no 742 0.207087936121089 1038 765861 SGTC_2971 9092186 9.93 µM 0.816480516266561 0.212368640206579 no 743 0.207112681309234 928 25236400 SGTC_227 fluconazole 33.516 µM 0.816423766753927 0.212384020824436 no 744 0.207128904009062 1047 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2282 7944268 200 µM 0.815742424373793 0.21256873343139 no 745 0.207323734634097 1007 2970414 SGTC_1872 amphotericin b 148 nM 0.813688027262517 0.213126250224351 no 746 0.207911847374826 1048 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2148 5546263 113.568 µM 0.812438758531401 0.213465690046763 no 747 0.208269956961763 1018 792097 SGTC_1245 0418-0076 17.2 µM 0.812169704974486 0.213538836023171 no 748 0.208347130207522 996 6790114 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.81193802089753 0.213601834285171 no 749 0.20841359819459 1025 6312947 SGTC_2401 5128683 200 µM 0.811916638460369 0.21360764902584 no 750 0.208419733245424 998 708373 SGTC_2713 st079149 53.4 µM 0.811590262119813 0.213696415265339 no 751 0.208513390394824 1015 3103253 SGTC_2999 9069765 71.4286 µM 0.810986659350543 0.213860636795734 no 752 0.208686665977956 1053 2097066 SGTC_1681 tripelennamine 100 µM 0.808944616180059 0.214416757737584 no 753 0.209273501969476 980 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1505 k297-0037 20.6 µM 0.807600373159646 0.214783301438265 no 754 0.209660335927284 997 4089396 SGTC_1388 3346-4487 254 µM 0.807567883209882 0.214792165192932 no 755 0.209669690789284 1076 3345614 SGTC_2207 7258803 200 µM 0.80607385277473 0.215199989050091 no 756 0.210100133489684 995 3666799 SGTC_1902 st060212 70.5 µM 0.80589094192694 0.215249948886453 no 757 0.210152867284478 1084 688944 SGTC_20 0481-0013 4.944 µM 0.805411967135285 0.215380806815761 no 758 0.21029099411148 1055 182045 SGTC_3046 9092212 49.47 µM 0.805111021265115 0.215463050099181 no 759 0.210377808193495 1007 25236637 SGTC_1955 wogonin 32.4 µM 0.805032491946551 0.215484513795628 no 760 0.210400465066278 1007 5281703 A flavanone. SGTC_1835 st008666 49.2 µM 0.803368022711716 0.215939739503643 no 761 0.210881025970812 928 690455 SGTC_923 1900-2434 73.3 µM 0.803253502610155 0.215971080769608 no 762 0.210914113542791 995 5910570 SGTC_2096 5468907 200 µM 0.801694723746798 0.216397941257605 no 763 0.21136478432202 1058 759785 SGTC_255 tunicamycin 200.472 nM 0.79995267165151 0.216875567099936 no 764 0.211869109465719 1027 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3164 9100705 49.47 µM 0.799001902264933 0.217136500457481 no 765 0.212144654484955 1013 17174235 SGTC_2796 7949634 45.45 µM 0.7971508268665 0.217645037760518 no 766 0.2126817202308 977 2971588 SGTC_1008 4106-0037 6 µM 0.796739721324797 0.217758072059622 no 767 0.212801104871254 1030 2905394 SGTC_1021 4476-0760 85.3 µM 0.7964154737728 0.217847248462553 no 768 0.212895293626572 1046 746768 SGTC_2856 9022925 19.48 µM 0.795977906476325 0.217967624089249 no 769 0.213022438528189 1022 4944862 SGTC_2878 9043973 25.97 µM 0.795365327252014 0.218136210254346 no 770 0.213200511439403 1035 6465167 SGTC_1692 fluoroquinolonic acid 71 µM 0.794384909690541 0.218406184478525 no 771 0.213485693215871 1026 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2596 sinensetin 100 µM 0.793476962082448 0.218656374449286 no 772 0.213749993253826 1003 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1775 st081588 35.1725 µM 0.792115199901644 0.219031924621731 no 773 0.214146754016552 1108 1426443 YGL099W LSG1 SGTC_1361 1608-0041 5.61 µM 0.791993565222232 0.219065487374278 no 774 0.214182214130551 1049 X1361 SGTC_2700 st077718 96.8 µM 0.789074895949635 0.219871724513891 no 775 0.21503411673957 1007 904970 SGTC_2308 7584454 197.62 µM 0.787704920244292 0.220250745566145 no 776 0.215434663453584 1075 893577 SGTC_2861 9024595 19.48 µM 0.787662119810491 0.220262592877682 no 777 0.215447184200742 1004 16482810 SGTC_1340 1486-1359 257 µM 0.786872722469635 0.220481166363483 no 778 0.215678188484645 1049 4309068 SGTC_3176 9106582 49.47 µM 0.786011065137231 0.220719889491236 no 779 0.215930502320803 964 17018027 SGTC_3232 9132874 49.47 µM 0.785828675624611 0.220770439687388 no 780 0.21598393224805 1051 3784940 SGTC_52 0329-0193 875 nM 0.78546545995051 0.220871126534215 no 781 0.216090356939075 1031 3739292 SGTC_2506 ethyl hematommate 54.16 µM 0.784209456734241 0.221219505173848 no 782 0.216458608550522 999 3940691 An allergen. SGTC_2630 antimycin a 100 µM 0.783863420161056 0.221315540822218 no 783 0.216560127895251 1122 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_789 1309-1135 70.6 µM 0.783594175815273 0.221390280788081 no 784 0.216639137179458 1101 3092424 SGTC_1368 1852-0141 284 µM 0.780867899283096 0.222147884710086 no 785 0.21744009693107 1016 2838987 SGTC_773 4358-1457 44.6 µM 0.780853574153104 0.222151869418775 no 786 0.217444310057781 1117 1186886 SGTC_2764 methyldopa 94.69 µM 0.77843964819858 0.222823914570563 no 787 0.218154936348101 1064 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_127 0180-0333 59.125 µM 0.775973963422688 0.223511563919356 no 788 0.218882179589848 1084 771601 SGTC_2444 5485484 36.41 µM 0.775273946107594 0.22370700996794 no 789 0.219088900633591 1104 6790631 SGTC_819 1013-0258 27.7 µM 0.775162171340555 0.223738226670554 no 790 0.219121919060117 1084 5753198 SGTC_1506 4226-2149 212 µM 0.774727069264181 0.223859766514598 no 791 0.219250476080367 1110 991114 SGTC_1400 3771-8998 51.5 µM 0.771979888183752 0.224628020003447 no 792 0.220063169663625 1032 670767 SGTC_911 3456-4043 236 µM 0.771421176812104 0.22478444732423 no 793 0.220228663444386 1099 914281 SGTC_26 0302-0163 425.158 µM 0.770092120801888 0.225156802908361 no 794 0.220622624765035 1103 3100915 SGTC_3089 9117425 49.47 µM 0.767009460645404 0.226021801562805 no 795 0.221537945319008 1050 9401657 SGTC_2745 rifampicin 24.3 µM 0.766243726204327 0.226236958595365 no 796 0.22176564753767 988 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3137 9097352 49.47 µM 0.76506472999366 0.226568460577849 no 797 0.222116500396807 1175 44120435 SGTC_3153 9100258 49.47 µM 0.765031878235268 0.226577701532632 no 798 0.222126281157723 1032 25236848 SGTC_1382 3002-2117 298 µM 0.764810205457939 0.226640061993922 no 799 0.222192284916022 1138 1497314 SGTC_928 2764-0428 58.7 µM 0.763339186299323 0.227054130974173 no 800 0.22263056891667 1088 662578 SGTC_1724 st037281 8.293 µM 0.762564295144254 0.227272422171485 no 801 0.222861642534446 1099 574124 YDL195W SEC31 SGTC_857 0438-0306 1.35 µM 0.761997381888281 0.227432199706757 no 802 0.223030783372159 1088 4686136 SGTC_2035 5154463 94.595 µM 0.758378187872507 0.22845371510649 no 803 0.224112305964213 1092 2769623 SGTC_2329 6138490 200 µM 0.757212332665196 0.228783325177326 no 804 0.224461331397627 979 720019 SGTC_467 ro 31-8220 72.8 µM 0.756823657495179 0.228893270557786 no 805 0.224577758727206 1081 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_362 0310-0100 9.03 µM 0.755916671169148 0.229149947024877 no 806 0.224849578953039 1085 790235 SGTC_591 4299-0174 154 µM 0.755429066267121 0.229288005550412 no 807 0.224995789278618 1077 5509088 SGTC_2897 9048598 12.99 µM 0.755334340657977 0.229314831193828 no 808 0.225024199389399 1104 6467404 SGTC_3230 9131665 49.47 µM 0.754019254288744 0.229687436366872 no 809 0.225418830141911 1053 15943720 SGTC_3166 9102297 49.47 µM 0.75366039694559 0.229789170755325 no 810 0.225526583959652 1078 25237072 SGTC_977 1348-1378 135 µM 0.753547818992167 0.229821091280271 no 811 0.225560393661282 1148 X977 SGTC_3056 9094900 49.47 µM 0.753187638885984 0.22992323397408 no 812 0.225668583148198 1069 25236784 SGTC_3297 9117502 71.43 µM 0.75128217661438 0.230464022480473 no 813 0.226241426698482 1122 7453720 SGTC_2839 9003951 25.97 µM 0.750932734920228 0.230563274486248 no 814 0.226346569241369 1112 2990634 SGTC_2252 omeprazole 400 µM 0.749230430054531 0.231047122001616 no 815 0.22685916556347 1034 4594 A proton pump inhibitor. SGTC_1567 st069303 68.4 µM 0.748768074217451 0.231178635583391 no 816 0.226998502684482 1127 5581319 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.747994808308252 0.231398678470654 no 817 0.227231644530804 1138 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1050 3232-1156 69.3 µM 0.74664648021135 0.231782642028066 no 818 0.22763849186624 1071 700529 SGTC_1496 4469-0713 57.4 µM 0.746047389452682 0.23195335899993 no 819 0.227819394271831 1094 746691 SGTC_2358 9037157 4 µM 0.743737082328925 0.232612359604685 no 820 0.228517775338753 1115 2388925 SGTC_501 nsc-95397 161 µM 0.742991088011289 0.232825371892201 no 821 0.2287435380185 1099 262093 SGTC_2650 prasterone 100 µM 0.737921255187285 0.234275886701907 no 822 0.230281150928612 1095 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_518 1021-0119 62.6 µM 0.733547320459366 0.235531308986277 no 823 0.231612338732649 1057 1097762 SGTC_3155 9099265 49.47 µM 0.732680494176733 0.235780548499067 no 824 0.231876661786113 1056 25236499 SGTC_1617 st002906 78 µM 0.732488738754428 0.235835703782674 no 825 0.231935156832517 1137 5150859 SGTC_190 3970-0790 3.722 µM 0.731953574391833 0.235989672602539 no 826 0.232098452336886 1123 2832352 SGTC_954 1189-0853 2.85 µM 0.729866271846263 0.236590726511907 no 827 0.23273596528506 1151 2828194 SGTC_342 k048-0088 23.3 µM 0.729500920874202 0.236696018524408 no 828 0.232847652344425 1135 6820570 SGTC_730 1436-0052 41.2 µM 0.728643999422273 0.236943079367196 no 829 0.233109728304605 1178 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_18 0111-0177 500 nM 0.728503854197667 0.236983498417631 no 830 0.233152605096007 1241 721752 SGTC_185 k048-0037 25.491 µM 0.727668539450759 0.237224488743114 no 831 0.233408256622967 1167 6827589 SGTC_770 0389-1121 67.2 µM 0.727337577868165 0.237320009180906 no 832 0.233509591780894 1188 6753108 SGTC_549 1661-1316 519 µM 0.727300839636773 0.237330613683467 no 833 0.233520841945849 1179 2857282 SGTC_1048 3161-0300 24.5 µM 0.726888320745964 0.237449705259979 no 834 0.233647186180122 1187 2165101 SGTC_2969 9091408 28.7 µM 0.725790931175995 0.237766674296639 no 835 0.233983473642584 1074 4286311 SGTC_2568 diosmetin 100 µM 0.725426179111447 0.237872080329256 no 836 0.234095308738015 1151 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2741 miltefosine 3.04 µM 0.72524245314847 0.237925183150861 no 837 0.234151651390813 1042 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3308 9128332 17.569 µM 0.72499668457945 0.237996228479468 no 838 0.234227032189843 1176 17332805 YDL196W YDL196W SGTC_2607 solasodine 47.35 µM 0.724882814047457 0.238029149443222 no 839 0.234261962493959 1154 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_302 1094-0063 18.9 µM 0.724029943966601 0.238275800962793 no 840 0.234523675932001 1105 5440289 SGTC_1766 st045414 44.774 µM 0.720872232928527 0.239190234117403 no 841 0.235494064104854 1212 253960 SGTC_79 0052-0007 94.094 µM 0.720313446764411 0.239352250986668 no 842 0.235666013687072 1177 2801472 SGTC_1731 st035964 63 µM 0.719003208273355 0.239732382136519 no 843 0.2360694714607 1108 6739575 SGTC_1527 coumarin 137 µM 0.71503632832572 0.240885273631179 no 844 0.237293297871101 1138 323 A hepatotoxic, DNA x-linker. SGTC_3226 9131256 49.47 µM 0.714437380022813 0.241059607248547 no 845 0.237478382349872 1079 17178073 SGTC_1201 1889-3372 45.9 µM 0.713966139448055 0.241196817667154 no 846 0.237624058808155 1102 5392199 SGTC_1398 3558-0053 112 µM 0.712638866843772 0.241583505718479 no 847 0.238034627249787 1098 4532369 SGTC_871 0574-0004 149 µM 0.711580439017012 0.241892109524875 no 848 0.238362311754199 1127 9551173 SGTC_1074 carmofur 3.8 µM 0.711222650621091 0.241996477560962 no 849 0.238473137279881 1216 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2387 9077560 195.08 µM 0.710982147276466 0.242066646891385 no 850 0.238547649426289 1165 5303272 SGTC_3081 9117243 49.47 µM 0.710882221952121 0.242095804379089 no 851 0.238578611788094 1171 45595589 SGTC_1751 st044839 27.194 µM 0.708887009811942 0.24267839130438 no 852 0.239197298459981 1177 5291326 SGTC_3214 9129694 49.47 µM 0.708247473278175 0.24286529166431 no 853 0.239395794954168 1143 17158655 SGTC_3231 9132313 49.47 µM 0.70755262182316 0.243068445700633 no 854 0.239611561778376 1162 4905967 SGTC_724 3910-0327 137 µM 0.706898327666864 0.243259825963763 no 855 0.239814831658009 1189 2885483 SGTC_2163 5671233 125 µM 0.702035807448562 0.244684655842157 no 856 0.24132841651229 1224 701023 SGTC_3211 9128781 49.47 µM 0.701930000501206 0.244715709578694 no 857 0.241361409256012 1126 17194361 SGTC_24 0417-1663 219 µM 0.70074120240472 0.245064760859183 no 858 0.241732268908812 1176 4329390 SGTC_1557 sumaresinolic acid 42.3 µM 0.700074973313397 0.24526049405189 no 859 0.241940242125391 1142 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2640 pentamidine 10.38 µM 0.6994524559718 0.245443460982903 no 860 0.242134657760504 1213 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1670 st016595 4.04 µM 0.698940582200768 0.245593963085602 no 861 0.242294582228501 1191 597879 SGTC_1214 0358-0031 63.7 µM 0.698095013686448 0.245842687286616 no 862 0.24255888811507 1202 4301366 SGTC_3181 9108277 49.47 µM 0.695299300040657 0.246666008823413 no 863 0.243433876417355 1172 17097298 SGTC_3324 9138759 60.749 µM 0.691221413916571 0.247869565618018 no 864 0.244713204357074 1215 45595710 SGTC_48 0382-0018 55 µM 0.689261635427315 0.248449092465208 no 865 0.245329318000112 1312 762596 SGTC_1066 ketoconazole 628 nM 0.688651417458144 0.248629687564593 no 866 0.24552132793806 1232 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1903 st060211 78.3 µM 0.688478304631205 0.248680933344389 no 867 0.245575813962853 1228 688960 SGTC_2788 5282734 71.43 µM 0.687810794996542 0.248878585749932 no 868 0.245785968640628 1232 743706 SGTC_3149 9097855 49.47 µM 0.686411360335393 0.249293235501249 no 869 0.246226871345741 1207 25236625 YMR079W SEC14 SGTC_2843 9000894 45.46 µM 0.686311586902305 0.249322812194816 no 870 0.246258321924223 1084 2242070 SGTC_3097 9117246 49.47 µM 0.684637522186343 0.249819347660968 no 871 0.246786341644599 1242 16423892 SGTC_3328 9140624 29.0385 µM 0.684544678859167 0.249846900785404 no 872 0.246815643252675 1218 4904392 SGTC_2377 9073351 62.6 µM 0.684121859214718 0.249972401417664 no 873 0.246949109840352 1182 7337946 YHR072W ERG7 SGTC_1237 0330-0133 46.1 µM 0.684078285900845 0.249985336678255 no 874 0.246962866319281 1174 X1237 YHR072W ERG7 SGTC_2219 9098279 200 µM 0.683981660657587 0.250014022307198 no 875 0.246993373222372 1215 902349 SGTC_2469 5655019 90.81 µM 0.681465160096966 0.250761723346724 no 876 0.24778860232089 1253 2788239 SGTC_2439 5492030 7.2 µM 0.680572307953923 0.251027291292441 no 877 0.248071077076185 1188 5722370 SGTC_1202 1988-0068 29.6 µM 0.678377012082028 0.251680887423448 no 878 0.248766340333881 1167 2850480 SGTC_815 1582-0027 36.9 µM 0.675154883159779 0.252641823452336 no 879 0.24978868374646 1248 3128206 SGTC_446 go6976 132 µM 0.675062634788342 0.252669363125795 no 880 0.249817985875514 1197 3501 A protein kinase C inhibitor. SGTC_2021 4019055 173 µM 0.67470041875967 0.25277751377944 no 881 0.249933059222433 1249 44827708 YER133W GLC7 SGTC_3162 9099653 49.47 µM 0.673902768431286 0.253015762544395 no 882 0.25018656597226 1206 25237511 SGTC_1152 3909-8331 15.9 µM 0.673029952498187 0.253276597704186 no 883 0.250464117796458 1214 16001939 SGTC_3075 9116269 49.47 µM 0.671488068869373 0.253737724483071 no 884 0.250954828819797 1252 17015205 YNL244C SUI1 SGTC_2816 7982706 58.44 µM 0.670024714709346 0.25417577305671 no 885 0.251421017664796 1235 2981853 SGTC_1672 st016598 6.51 µM 0.669803620573285 0.25424199107487 no 886 0.251491492629455 1209 4665860 YNL267W PIK1 SGTC_1116 jasmonic acid  1.58368 µM 0.668078422272656 0.254759000994308 no 887 0.252041767343137 1279 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_11 0438-0307 1.3 µM 0.667609934620838 0.25489949302456 no 888 0.252191307248523 1237 4011476 SGTC_2620 irigenin 100 µM 0.66735729301638 0.254975273067651 no 889 0.252271969135164 1268 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3022 9087993 49.47 µM 0.666941489951163 0.255100019176829 no 890 0.252404753839839 1261 17173644 SGTC_13 0199-0087 65 µM 0.666813085654637 0.255138548518509 no 891 0.252445766576169 1264 4589825 SGTC_1825 st052143 62.6 µM 0.666701987743228 0.255171887314934 no 892 0.252481254432309 1258 674173 SGTC_2212 7123476 200 µM 0.665955523337112 0.255395949011603 no 893 0.252719764705476 1197 1085715 SGTC_2708 st078559 56 µM 0.665348465763178 0.255578241584772 no 894 0.252913819158594 1166 17250902 SGTC_1144 3486-0183 12.5 µM 0.663926614158751 0.256005473517169 no 895 0.253368640705758 1269 6744069 SGTC_3094 9117742 49.47 µM 0.661647844453354 0.256690964820433 no 896 0.254098468686259 1216 17149698 SGTC_988 1497-1057 103 µM 0.660881268190109 0.256921778166537 no 897 0.254344229862253 1260 3533044 SGTC_2327 6189656 200 µM 0.660586050248895 0.257010696016429 no 898 0.254438908732088 1298 5349088 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.660229848551673 0.257118003108784 no 899 0.254553170185067 1266 3256 An antibiotic and ribosome inhibitor. SGTC_2093 5331342 194.4 µM 0.659954034014615 0.257201109270768 no 900 0.25464166371597 1246 33839 SGTC_2451 5856223 45.7 µM 0.65782732117666 0.25784238152759 no 901 0.255324548186829 1238 2179896 SGTC_1792 st045773 43.6 µM 0.657327571902356 0.257993192294764 no 902 0.255485155756333 1209 2919270 SGTC_686 1319-0111 510 µM 0.657135173829019 0.258051265007267 no 903 0.25554700200541 1315 4562600 SGTC_490 phenamil 164 µM 0.655137380197439 0.258654671966929 no 904 0.256189653534215 1200 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3177 9107506 49.47 µM 0.653942442691964 0.259015935735444 no 905 0.256574444157709 1203 8897194 SGTC_861 0443-0273 110 µM 0.653772427138842 0.259067357494729 no 906 0.256629216568548 1270 6149169 SGTC_1575 cyproterone acetate 48 µM 0.653002784764037 0.259300204363831 no 907 0.256877241613679 1219 9880 An androgen receptor antagonist and liver toxin. SGTC_1716 st033144 30.6155 µM 0.65233327316558 0.25950284568216 no 908 0.257093099912212 1279 674617 SGTC_2669 eugenol 100 µM 0.65127484849409 0.259823366223633 no 909 0.257434540638689 1249 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.650116384275349 0.260174415515009 no 910 0.257808523323672 1250 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2103 5378138 10 µM 0.650014797016774 0.260205211145992 no 911 0.257841331801424 1296 244142 SGTC_3305 9127027 53.8275 µM 0.648920958627657 0.260536921344632 no 912 0.258194733520096 1205 41905295 SGTC_2066 5222451 176 µM 0.644180052100504 0.261977129929616 no 913 0.259729342345443 1276 2281147 SGTC_1979 st071809 45.3 µM 0.643964989189825 0.262042559111749 no 914 0.259799068629745 1352 4976333 SGTC_2474 5321570 43.32 µM 0.643955828013291 0.262045346427732 no 915 0.259802039020691 1300 2841384 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.64329198053906 0.262247364495003 no 916 0.260017329462057 1300 4213774 SGTC_1713 st033146 12.748 µM 0.643101228862631 0.262305427649665 no 917 0.260079208593441 1292 674619 SGTC_1638 st008370 60.6 µM 0.642545900825158 0.262474502164154 no 918 0.260259398150067 1276 24207134 SGTC_386 1509-0011 3.07 µM 0.641363839289274 0.262834576891212 no 919 0.260643160569761 1304 3107280 SGTC_2013 4024628 200 µM 0.639878119761421 0.263287508678895 no 920 0.261125919904298 1313 5230760 SGTC_3283 9109332 35.8195 µM 0.637703598462513 0.263951144311276 no 921 0.261833321332821 1211 17027281 SGTC_2520 obtusaquinone 4.71 µM 0.637645391893798 0.263968919908439 no 922 0.261852270221761 1345 5967872 SGTC_2107 5363541 170.161 µM 0.637320993903453 0.26406799838929 no 923 0.261957889422594 1266 244052 SGTC_53 0973-0023 39.979 µM 0.636415031377773 0.26434480014227 no 924 0.262252973096508 1268 674768 SGTC_1734 st037168 69.4 µM 0.636372987851718 0.264357649426675 no 925 0.26226667134826 1281 708907 SGTC_400 oxethazaine 37.5 µM 0.6346761350089 0.264876504484646 no 926 0.262819830748629 1267 4621 A local anesthetic. SGTC_646 4092-0839 27.3 µM 0.632490165399757 0.265545681253369 no 927 0.263533316387969 1336 877796 SGTC_1493 4348-0038 111 µM 0.630874443287537 0.266040842422911 no 928 0.264061311696679 1339 800424 SGTC_859 0439-0102 54.6 µM 0.627744900253931 0.26700126402865 no 929 0.265085533273755 1314 610143 SGTC_912 3474-0017 2.18 µM 0.627671708511618 0.26702374668926 no 930 0.265109511237077 1369 3360550 SGTC_1000 4048-0884 8.67 µM 0.627468714434386 0.267086106361552 no 931 0.265176018827511 1302 13040088 SGTC_1315 1237-0019 3.69 µM 0.627265107929039 0.267148661556828 no 932 0.265242735579851 1296 825140 SGTC_619 1652-1634 108 µM 0.625821072216032 0.267592533069853 no 933 0.265716154348745 1266 5400454 SGTC_2101 5377231 179.231 µM 0.624855507802402 0.267889538083595 no 934 0.266032947889157 1340 2844213 SGTC_2072 5231554 129 µM 0.624377607386106 0.268036600365379 no 935 0.26618981372883 1340 789545 SGTC_2204 7233102 200 µM 0.624204340380502 0.268089929128421 no 936 0.266246698385228 1256 2172480 SGTC_1454 4239-0054 42.6 µM 0.620669066746839 0.2691791936402 no 937 0.267408693118734 1404 1340767 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.620573139507947 0.269208781001331 no 938 0.267440258663355 1285 17037758 SGTC_1495 4469-0029 237 µM 0.620473418557656 0.269239540206892 no 939 0.267473074547957 1311 793680 SGTC_2636 apigenin dimethyl ether 100 µM 0.618878862209213 0.269731624896042 no 940 0.2679980822679 1320 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_130 0136-0219 337.655 µM 0.618545891711308 0.269834437372503 no 941 0.268107778262292 1286 234244 SGTC_1499 4480-0877 67.3 µM 0.618487433996737 0.269852489591966 no 942 0.268127039288767 1253 2861909 SGTC_1096 rimcazole 32.2 µM 0.617942421074113 0.270020823122504 no 943 0.268306647184262 1254 18528119 A dopamine reuptake inhibitor. SGTC_2711 st079103 59.1 µM 0.617707994747195 0.270093244556117 no 944 0.268383920511369 1312 54693780 SGTC_146 3448-8650 53.125 µM 0.617318164907684 0.270213696379562 no 945 0.268512443860864 1318 2891488 YIL048W NEO1 SGTC_1432 4049-0298 68.4 µM 0.617289704560395 0.270222491270331 no 946 0.268521828190031 1349 741646 SGTC_2815 7968870 71.43 µM 0.616720311748472 0.270398476597063 no 947 0.268709610697731 1308 2977326 YHR190W ERG9 SGTC_1271 0832-2808 169 µM 0.614971939177887 0.270939213339331 no 948 0.269286626029213 1335 3663794 SGTC_136 0097-0015 404.482 µM 0.614271151790796 0.271156104266052 no 949 0.269518081192014 1311 4861337 SGTC_3261 9137475 49.47 µM 0.61322811764384 0.271479079449163 no 950 0.26986275770206 1240 17027690 SGTC_3278 9139605 49.47 µM 0.612898059379524 0.271581321781985 no 951 0.269971873260097 1351 7958859 SGTC_2205 7238770 200 µM 0.612769025444164 0.271621297908919 no 952 0.270014537215397 1353 279867 SGTC_3208 9114115 49.47 µM 0.610850569000743 0.272216002118131 no 953 0.270649255949807 1280 650895 SGTC_2184 6075246 200 µM 0.60766185214198 0.273205905114728 no 954 0.271705884506741 1351 2267320 SGTC_2134 5324836 1.464 µM 0.604458583509709 0.274202117966329 no 955 0.272769398420485 1342 699272 SGTC_2428 5615643 7.78 µM 0.603020419340723 0.274649968202878 no 956 0.273247552687997 1356 2253075 SGTC_2558 carylophyllene oxide 100 µM 0.602663560753886 0.274761151272726 no 957 0.273366263670312 1385 6708694 An oxygenated terpenoid and antifungal agent. SGTC_266 formosanin C 406 nM 0.597943439224976 0.276233839482005 no 958 0.274938836894357 1325 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.597597282077288 0.276341993528163 no 959 0.275054339098996 1378 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1313 1220-0047 237 µM 0.597290752821494 0.276437783493457 no 960 0.27515663861986 1394 3528706 SGTC_1260 0700-1617 7.75 µM 0.595797404709162 0.276904685466425 no 961 0.275655288856461 1370 2853078 SGTC_1228 0124-0032 52.5 µM 0.590246852688982 0.278643467771446 no 962 0.277512582500194 1435 X1228 SGTC_2778 tioconazole 65.09 nM 0.589795101410436 0.278785218337996 no 963 0.277664013616583 1314 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_817 1391-0715 46 µM 0.589434731602348 0.278898320377003 no 964 0.277784841772517 1316 1353946 SGTC_2015 5119600 184 µM 0.588903237203455 0.279065170589536 no 965 0.277963093022615 1398 2828786 SGTC_1453 4237-0541 195 µM 0.587647663179848 0.279459521298871 no 966 0.278384405825498 1332 739892 SGTC_2759 disulfiram 3.38 µM 0.584752243878341 0.280369944954806 no 967 0.279357159861309 1315 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2555 cholic acid 100 µM 0.58394306994886 0.280624634779851 no 968 0.279629307373599 1355 6708657 Influences liver metabolism. SGTC_4 0960-0234 25.671 µM 0.582556774325189 0.2810612353052 no 969 0.280095855709018 1363 6821112 SGTC_1921 5740136 50 µM 0.581315859866243 0.281452327569677 no 970 0.280513796736286 1437 1774243 SGTC_992 3909-8734 162 µM 0.580912025860342 0.281579658344494 no 971 0.280649873432842 1356 4288319 SGTC_3199 9111318 49.47 µM 0.579340241198805 0.282075513830416 no 972 0.281179808886167 1398 8548020 SGTC_2638 epoxomicin 18 µM 0.578663744355677 0.282289059609713 no 973 0.28140804201043 1404 9915668 A protesome inhibitor. SGTC_2032 5185112 25.99 µM 0.577870809608396 0.282539459639917 no 974 0.281675672125591 1310 5718189 SGTC_622 1348-1566 26.3 µM 0.576468892684274 0.282982430636371 no 975 0.282149145038188 1437 7340407 SGTC_502 l-744,832 89.3 µM 0.575602261046018 0.28325643140741 no 976 0.282442026210089 1352 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1935 st074532 41.6 µM 0.575361907770494 0.283332445838874 no 977 0.282523280325638 1438 2829742 SGTC_2799 7812892 81.82 µM 0.575348978065622 0.283336535280961 no 978 0.282527651675662 1406 20205235 SGTC_606 k015-0008 38.6 µM 0.57479889244061 0.283510544064024 no 979 0.282713657947146 1471 1970475 SGTC_1065 prochlorperazine maleate 2.48 µM 0.574642556876759 0.283560007093254 no 980 0.282766532081085 1396 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_704 1310-0270 142 µM 0.573620141710531 0.283883591065077 no 981 0.283112439426693 1337 5718033 SGTC_2575 plumbagin 510 nM 0.573478751434265 0.283928353552518 no 982 0.283160291094201 1334 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2471 5466956 24.79 µM 0.572550518598943 0.284222304925966 no 983 0.283474535535383 1402 724419 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.571367117886475 0.284597273337718 no 984 0.283875406870172 1402 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3345 9148410 3.559 µM 0.569787050044569 0.285098296320482 no 985 0.284411069936211 1385 4903596 SGTC_182 3448-4371 550.524 µM 0.568048042959189 0.285650202837041 no 986 0.285001173104405 1443 3491403 SGTC_2641 levomentholum 100 µM 0.564678194058816 0.28672113228939 no 987 0.286146334359323 1352 16666 SGTC_2277 7947813 106.88 µM 0.563956066658229 0.286950869971927 no 988 0.28639201589298 1481 1246798 SGTC_2857 9024691 58.44 µM 0.563945780464107 0.286954143052581 no 989 0.286395516175777 1408 16478292 SGTC_2265 7929201 200 µM 0.563631936244189 0.287054017202108 no 990 0.286502323795904 1357 1265108 SGTC_2108 5365811 200 µM 0.562634512445535 0.287371535044219 no 991 0.286841892969566 1467 780283 SGTC_1239 0337-0584 35.4 µM 0.561239271631331 0.287815971694441 no 992 0.287317217209717 1495 914301 YML130C ERO1 SGTC_2292 7671323 168.05 µM 0.559383744498243 0.288407529336782 no 993 0.287949926448877 1380 937504 SGTC_2472 5377652 49.4 µM 0.559173497971772 0.288474593830124 no 994 0.288021659094692 1369 1610903 SGTC_407 eburnamonine 100 µM 0.558053240209977 0.288832057804164 no 995 0.288404014694454 1346 3195 SGTC_1466 k213-0079 57.5 µM 0.557772032188794 0.28892182143131 no 996 0.288500031467369 1385 3657981 SGTC_492 tmb-8 126 µM 0.556068890950111 0.289465756707867 no 997 0.289081880369451 1327 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1156 4092-0367 4.88 µM 0.555460861319556 0.289660060663261 no 998 0.289289736835125 1408 1357585 SGTC_324 1315-0088 19.6 µM 0.55448649018205 0.28997156151429 no 999 0.289622974460351 1374 6787421 SGTC_937 3122-0005 46.7 µM 0.552871867809356 0.290488092507616 no 1000 0.290175576143414 1412 759535 SGTC_2182 6325192 200 µM 0.550329749607728 0.291302208671835 no 1001 0.291046611442842 1363 736248 SGTC_2919 7978188 46.38 µM 0.549154874728623 0.29167882310916 no 1002 0.291449584642163 1435 2980291 SGTC_884 0851-0618 334 µM 0.54902534874282 0.291720357464241 no 1003 0.291494026999754 1411 9642473 SGTC_662 k832-1615 104 µM 0.548565273207379 0.291867909526439 no 1004 0.29165191153834 1445 5878478 SGTC_2724 maprotiline 69.64 µM 0.547881691458647 0.29208720704253 no 1005 0.291886570495049 1441 4011 A tricyclic antidepressant. SGTC_1354 1498-1681 81 µM 0.547738840592011 0.292133044225163 no 1006 0.291935619240946 1430 5754243 SGTC_1338 1486-1223 76 µM 0.547157546300746 0.292319601185163 no 1007 0.292135249878869 1487 3444526 SGTC_1456 k015-0012 13 µM 0.547044336874935 0.292355940356412 no 1008 0.29217413614667 1503 2989616 SGTC_229 benomyl 22.8748 µM 0.546956775320718 0.292384048240381 no 1009 0.292204214287365 1392 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_967 1306-0166 352 µM 0.546930570641753 0.292392460373672 no 1010 0.292213216098167 1451 4437607 SGTC_3194 9111903 49.47 µM 0.546910994875843 0.292398744590187 no 1011 0.292219940834136 1463 17087251 SGTC_2771 fluoxetine 41.05 µM 0.545852245328325 0.292738718096277 no 1012 0.292583753403333 1458 3386 A selective serotonin reuptake inhibitor. SGTC_1950 st077106 7.18 µM 0.543368438295454 0.293537009314085 no 1013 0.293438075965377 1394 13831864 SGTC_3068 9116768 49.47 µM 0.543263170996723 0.293570864295628 no 1014 0.29347430889097 1395 41904888 SGTC_237 nikkomycin 200 µM 0.541630381779078 0.294096216454863 no 1015 0.294036578880903 1491 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1033 k072-0102 21.3 µM 0.54114933169026 0.294251077800624 no 1016 0.294202329003867 1481 5965931 SGTC_2617 dihydrotanshinone i 20.83 µM 0.540981647215489 0.294305068231841 no 1017 0.294260116338125 1420 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_685 1278-0033 54.9 µM 0.540638030453204 0.294415718985719 no 1018 0.294378549740302 1493 3590572 SGTC_1693 xanthone 101.9 µM 0.538286256895001 0.295173547223243 no 1019 0.295189718912411 1469 7020 An insecticide. SGTC_2323 6148992 148.28 µM 0.537953865602149 0.295280728363009 no 1020 0.295304449622523 1397 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1700 st030840 7.9285 µM 0.536304890810417 0.295812712709801 no 1021 0.295873925507142 1504 5499307 SGTC_1373 2887-0003 58.5 µM 0.536024981714959 0.295903059333948 no 1022 0.295970642579481 1435 776948 SGTC_1831 st055328 12 µM 0.53432001072042 0.296453648502651 no 1023 0.296560074930931 1492 1103068 SGTC_1455 4262-0120 131 µM 0.532854685062607 0.296927223437754 no 1024 0.297067087838842 1511 1529587 SGTC_1105 epirubicin 18.1 µM 0.532137194469419 0.297159233594398 no 1025 0.297315489074745 1384 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.530040275869594 0.297837774771944 no 1026 0.298042003199964 1573 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1795 st049545 62.3 µM 0.529941061006929 0.297869897175533 no 1027 0.298076397960421 1438 5291882 SGTC_1339 1486-1321 22.7 µM 0.529903120444473 0.297882181458895 no 1028 0.298089551271828 1439 3469382 SGTC_1709 st033179 39.1045 µM 0.529520307323495 0.298006140483075 no 1029 0.298222280496444 1429 573381 SGTC_3320 9137005 35.139 µM 0.528028143377618 0.298489543551666 no 1030 0.298739901316857 1428 4908713 SGTC_973 1325-0077 65.9 µM 0.527046869478878 0.298807632437137 no 1031 0.299080520521609 1547 2835149 SGTC_1117 retinoic acid 1.10837 µM 0.525723358086868 0.299236904552183 no 1032 0.299540216060854 1544 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_969 1313-0238 134 µM 0.523377107562545 0.299998582161572 no 1033 0.300355925847865 1479 5212874 SGTC_496 calpeptin 138 µM 0.520800052866218 0.30083619655672 no 1034 0.301253033131789 1402 73364 A calpain inhibitor. SGTC_1972 st070201 17.4 µM 0.519767835787197 0.301171991435149 no 1035 0.301612699920122 1515 2829099 SGTC_1276 0871-0068 94.2 µM 0.518655986396883 0.30153388062103 no 1036 0.302000329793652 1507 3414906 SGTC_1380 2291-0730 164 µM 0.518102447234368 0.301714121679696 no 1037 0.302193396441553 1434 2999191 SGTC_2887 9044784 58.44 µM 0.516555540478668 0.302218075501212 no 1038 0.302733229167236 1429 6465546 SGTC_621 3584-0052 32.1 µM 0.515912241131766 0.302427761775563 no 1039 0.302957852046161 1487 2273927 SGTC_581 0958-0271 211 µM 0.515829900933574 0.302454605637352 no 1040 0.302986608419067 1431 4591145 SGTC_1273 0849-0096 14.1 µM 0.515509235092057 0.302559156609848 no 1041 0.303098608937565 1447 5286025 SGTC_2891 9063876 19.48 µM 0.515146731016068 0.302677368164397 no 1042 0.303225244796565 1465 6472478 SGTC_2608 thymoquinone 42.66 µM 0.514159755043289 0.302999323051623 no 1043 0.303570151222865 1393 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1645 Cervolide 78 µM 0.514041022375919 0.303038064372172 no 1044 0.303611655078708 1421 23173 A fragrance. SGTC_29 0299-0004 12.984 µM 0.51381729897596 0.30311106917459 no 1045 0.30368986608174 1387 16871 A napthoquinone isolated from Swertia calycina. SGTC_2523 spermine 47.74 µM 0.513795953695619 0.303118034918634 no 1046 0.303697328604257 1504 1103 A DNA binding polyamine. SGTC_1554 st069299 38.7 µM 0.511431489379759 0.303890088712357 no 1047 0.30452447496034 1469 24207999 SGTC_2536 dehydroabietamide 32.04 µM 0.509692542232646 0.304458455346821 no 1048 0.30513343929904 1585 3983547 SGTC_485 niflumic acid 177 µM 0.508081756555516 0.30498535467502 no 1049 0.305698004375442 1501 4488 A COX2 inhibitor. SGTC_1769 st044406 64.4 µM 0.507927269047427 0.305035909904209 no 1050 0.305752175088495 1475 670903 SGTC_303 1348-1668 34.2 µM 0.50682841953159 0.305395609981349 no 1051 0.306137606905264 1477 5380509 SGTC_2772 vinpocetine 57.06 µM 0.506066526378035 0.30564512031309 no 1052 0.30640497417487 1514 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_495 decylubiquinone 155 µM 0.505273195635513 0.305905021995737 no 1053 0.306683483253006 1422 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3144 9087057 49.47 µM 0.502230425885052 0.306902764150506 no 1054 0.307752721459369 1532 17249618 SGTC_3086 9117350 49.47 µM 0.500578626609552 0.30744499908875 no 1055 0.308333853836782 1422 2679265 SGTC_2754 granisetron 64.02 µM 0.50040412524885 0.307502307134655 no 1056 0.308395274615683 1566 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1089 terbinafine 2.25 µM 0.498736564418701 0.30805018814648 no 1057 0.308982490995739 1535 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_779 1360-0071 233 µM 0.4982250006547 0.308218349476267 no 1058 0.309162731510437 1644 7566 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.496895602943804 0.308655537511664 no 1059 0.309631336209605 1470 688662 SGTC_2888 9058547 12.99 µM 0.493432858935553 0.309795574322146 no 1060 0.310853384799566 1426 16476514 SGTC_2255 7941087 197.44 µM 0.49070151821 0.310696104831313 no 1061 0.31181878627165 1592 935561 SGTC_2038 4100038 30.985 µM 0.490247700593846 0.310845839874939 no 1062 0.311979315202339 1524 3596803 SGTC_2912 7964298 10.93 µM 0.48743938544035 0.311773126604946 no 1063 0.312973494136733 1495 2975850 SGTC_600 1495-0418 41.6 µM 0.487248643959707 0.311836151544756 no 1064 0.313041068480305 1508 5377768 SGTC_1259 0671-0132 43 µM 0.486707170465898 0.31201509563435 no 1065 0.313232931529503 1489 X1259 SGTC_474 dl-dihydrosphingosine 5 µM 0.486041915085129 0.31223500743412 no 1066 0.313468724070053 1537 3058739 A sphingolipid protein kinase C inhibitor. SGTC_588 3970-1144 52.9 µM 0.483190395560546 0.313178384407235 no 1067 0.314480277114157 1525 1888707 SGTC_2046 4110841 106 µM 0.483166220052015 0.313186387706315 no 1068 0.314488859147783 1517 44119630 YMR134W ERG29 SGTC_2716 st080858 38.6235 µM 0.482978134746155 0.313248656328667 no 1069 0.314555630739465 1507 5296050 SGTC_1034 k072-0165 12.7 µM 0.481973345047059 0.313581398061927 no 1070 0.314912440786376 1609 5835461 SGTC_283 0987-0079 11.7 µM 0.477325076638907 0.315122669407893 no 1071 0.316565328447322 1564 411556 SGTC_1364 1653-0028 37.6 µM 0.477013558805038 0.315226077958226 no 1072 0.316676233313565 1531 5718652 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.476331497384305 0.315452539243919 no 1073 0.31691911460608 1482 803109 SGTC_801 0866-0028 10.1 µM 0.474094707757214 0.316195694998134 no 1074 0.317716186175771 1529 6849771 SGTC_2105 5350118 200 µM 0.473896662040148 0.316261529982861 no 1075 0.317786799821577 1501 2133313 SGTC_134 0269-0018 6.916 µM 0.473654957825337 0.316341885956026 no 1076 0.317872988982949 1461 4378915 SGTC_1611 st001856 99.4 µM 0.472747573490824 0.31664362852835 no 1077 0.318196640646256 1469 647478 SGTC_1300 1094-0077 113 µM 0.47079224417846 0.31729427056538 no 1078 0.318894551811307 1478 5532636 SGTC_2483 5729050 27.16 µM 0.469441080029065 0.317744205011906 no 1079 0.319377195367477 1665 2865180 SGTC_2539 epi(13)torulosol 80 µM 0.469110759646459 0.31785424189974 no 1080 0.319495234306133 1484 6708597 SGTC_766 1391-0721 126 µM 0.464380661284736 0.319431700856262 no 1081 0.321187521454298 1639 1020919 YIL115C NUP159 SGTC_3293 9120939 62.045 µM 0.462887017935715 0.319930503240367 no 1082 0.321722676676723 1581 934087 SGTC_1860 st056228 74.6 µM 0.462215328059368 0.320154920394887 no 1083 0.321963456133804 1505 688679 SGTC_2054 5233173 129 µM 0.459121258105269 0.321189523541731 no 1084 0.323073545892702 1570 6889 SGTC_3106 9121286 49.47 µM 0.458684770437101 0.321335589429547 no 1085 0.32323027605192 1588 15943471 SGTC_1868 st057644 42.7 µM 0.454492193749656 0.322739994857403 no 1086 0.324737304613714 1518 688665 SGTC_2384 9036245 200 µM 0.453784947281918 0.322977154388636 no 1087 0.324991809426216 1625 6462766 SGTC_2698 st077697 67.5 µM 0.453757017217286 0.322986521599156 no 1088 0.325001861823166 1494 3154499 SGTC_3107 9121808 49.47 µM 0.45213528323463 0.323530612583855 no 1089 0.325585763430275 1559 662681 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.451783237475025 0.323648773679028 no 1090 0.325712573321086 1585 368090 SGTC_3098 9119039 49.47 µM 0.451765958834459 0.323654573562212 no 1091 0.32571879775445 1541 17161528 SGTC_2149 5554786 194.827 µM 0.451762354268479 0.323655783504327 no 1092 0.325720096264394 1559 745063 YPR165W RHO1 SGTC_2285 7945142 200 µM 0.449326231955299 0.324473940750459 no 1093 0.326598168644677 1564 2970608 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.449041523205764 0.324569613911175 no 1094 0.326700851494748 1638 756377 SGTC_2605 digitonin 300 nM 0.448970942577873 0.324593333525405 no 1095 0.326726309083528 1616 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1407 3909-7909 12.3 µM 0.448822143156653 0.324643341997937 no 1096 0.326779981899103 1544 4411780 SGTC_2262 9014885 67.46 µM 0.448614274373378 0.324713207779903 no 1097 0.326854967378062 1597 6457424 SGTC_181 1447-1644 8.07 µM 0.448543340786426 0.324737050339875 no 1098 0.326880557183257 1606 534600 SGTC_2646 retinol 96.75 µM 0.446443767610188 0.325443094452127 no 1099 0.327638361680385 1576 445354 A vitamin A analog and teratogen. SGTC_1448 4255-0083 152 µM 0.44575753727316 0.325673995930603 no 1100 0.327886198834699 1701 5399660 SGTC_1815 st051655 58.2 µM 0.443488221096537 0.326438047146595 no 1101 0.328706318582587 1624 5984156 SGTC_2275 7947463 200 µM 0.442428995174913 0.326794925337506 no 1102 0.329089400527881 1547 1225414 SGTC_83 0170-0301 39.027 µM 0.439899590756338 0.327647782065473 no 1103 0.330004916153422 1577 3089716 SGTC_2106 5357045 167.29 µM 0.439315551039832 0.327844834821258 no 1104 0.330216453811574 1637 668842 SGTC_2994 9053520 71.4286 µM 0.438767916618539 0.328029648126189 no 1105 0.3304148548809 1674 4647384 SGTC_763 3453-1109 128 µM 0.438073728714096 0.328263980193024 no 1106 0.330666418954084 1628 1560353 SGTC_718 1130-0073 349 µM 0.437788155689773 0.328360398672029 no 1107 0.330769928877066 1639 6740020 SGTC_595 3909-8003 73.7 µM 0.434186742266361 0.329577329125403 no 1108 0.332076419837827 1610 699517 SGTC_1180 1193-0155 285 µM 0.433503818178891 0.329808295801193 no 1109 0.33232439641507 1541 2921347 SGTC_432 NS 1619 61.3 µM 0.432449357002145 0.330165044735319 no 1110 0.332707426006705 1602 4552 A K+/calcium channel activator. SGTC_1917 st066507 28.5 µM 0.432377289519408 0.330189432496837 no 1111 0.3327336106673 1556 3156428 SGTC_1257 0669-0121 16 µM 0.432055901222875 0.330298199637075 no 1112 0.332850392312322 1694 4307855 SGTC_97 0535-0701 19.132 µM 0.43180309345224 0.330383767211348 no 1113 0.332942265508083 1500 2832013 YGL099W LSG1 SGTC_935 2996-0153 430 µM 0.43027042891749 0.330902716270854 no 1114 0.333499467640001 1704 23738523 SGTC_798 1287-0182 476 µM 0.430064523210743 0.330972459237916 no 1115 0.333574352951743 1709 1649755 SGTC_2545 solidagenone 89.61 µM 0.429862678768269 0.331040832295122 no 1116 0.333647767669528 1538 6708572 An anti ulcer agent SGTC_3335 9143315 29.6265 µM 0.429549635250654 0.331146884222234 no 1117 0.333761640236271 1563 4899691 SGTC_1691 st019933 84.6 µM 0.428174494381285 0.331612910607312 no 1118 0.334262042109716 1657 6176082 SGTC_1187 1391-0724 117 µM 0.427776904783784 0.331747699789116 no 1119 0.334406776485731 1608 6997986 SGTC_2499 avocadenofuran 51.48 µM 0.427060603175004 0.331990592368412 no 1120 0.334667593579963 1517 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_674 0498-0004 451 µM 0.426642266454506 0.332132479929174 no 1121 0.334819953717878 1554 4231473 SGTC_2027 5150920 200 µM 0.426317705149846 0.332242578198423 no 1122 0.334938179158173 1641 786715 SGTC_2477 5967686 25.23 µM 0.425464230982361 0.33253216432233 no 1123 0.335249145648683 1532 776118 SGTC_478 N-arachidonylglycine 10 µM 0.424806849142265 0.332755283952374 no 1124 0.335488742176691 1596 5283389 SGTC_976 1348-1067 47.6 µM 0.423821878041437 0.333089700356011 no 1125 0.335847860668779 1586 5310671 YGL099W LSG1 SGTC_1623 st003709 20.3 µM 0.42379684700113 0.333098200600793 no 1126 0.335856988890896 1553 16192618 SGTC_1039 k821-0043 94 µM 0.421381426287168 0.333918851657312 no 1127 0.336738289902098 1697 15992768 SGTC_971 1315-0384 26.7 µM 0.421353531172548 0.333928333810031 no 1128 0.336748473086389 1552 6769120 SGTC_73 0327-0325 16.231 µM 0.418003605993131 0.335067815253581 no 1129 0.337972240374827 1743 53298 SGTC_1676 st018489 23.4 µM 0.414621820386814 0.336219675825559 no 1130 0.339209385975531 1613 3696235 SGTC_3110 9122132 49.47 µM 0.413960318370537 0.336445168520405 no 1131 0.339451584063873 1692 918317 SGTC_1209 2323-2347 50.3 µM 0.407936297240036 0.33850133472366 no 1132 0.341660221879509 1655 5412760 SGTC_1891 st059073 26.2 µM 0.407367094276877 0.338695869931119 no 1133 0.341869195614683 1754 688754 SGTC_2803 7707263 71.43 µM 0.406783536038 0.338895355991444 no 1134 0.342083489968526 1581 2199229 SGTC_1788 fluconazole 20 µM 0.406612883641651 0.338953701083316 no 1135 0.342146166586974 1590 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1172 0370-0043 85 µM 0.405585288752438 0.339305111610399 no 1136 0.342523669953973 1662 376585 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.404947023541365 0.339523451997179 no 1137 0.34275822610571 1583 688664 SGTC_2634 4'-methoxyflavone 100 µM 0.404226120499523 0.33977012625995 no 1138 0.343023223754237 1603 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2411 st077133 39.94 µM 0.403847557915507 0.339899688016657 no 1139 0.343162410981393 1770 1403142 YNL221C POP1 SGTC_1996 st072960 66.8 µM 0.402505440716446 0.340359175361029 no 1140 0.343656042539192 1726 1719405 SGTC_56 0957-0365 83.25 µM 0.399468401904441 0.341399810668557 no 1141 0.344774050901539 1607 6752360 SGTC_2946 9065502 71.43 µM 0.399172118682835 0.341501396270367 no 1142 0.344883192810788 1577 16489101 SGTC_2828 7998861 71.43 µM 0.395087865688476 0.342902917337549 no 1143 0.346389021863458 1768 2988188 SGTC_1013 4112-3890 241 µM 0.395018153779831 0.342926857985034 no 1144 0.34641474521463 1601 705171 SGTC_2747 doxorubicin 7.63 µM 0.393084207115172 0.343591270184092 no 1145 0.347128644051071 1682 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3024 9090631 49.47 µM 0.392806148436532 0.343686837740177 no 1146 0.347231331579574 1748 25236383 SGTC_2236 dapsone 200 µM 0.392721770147267 0.343715840166623 no 1147 0.347262494839517 1671 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3013 9080133 71.4286 µM 0.392582214231772 0.343763810213754 no 1148 0.347314039004956 1693 17050193 SGTC_696 1560-0013 611 µM 0.387626022932627 0.345469045274922 no 1149 0.349146404129013 1701 1650269 SGTC_186 3455-3465 67.277 µM 0.38507764931201 0.34634706783106 no 1150 0.350089943417157 1647 755278 SGTC_3034 9090421 49.47 µM 0.384596855160088 0.346512814566993 no 1151 0.350268062231364 1734 17173761 SGTC_3100 9120536 49.47 µM 0.384248918592757 0.346632778930758 no 1152 0.350396982117005 1731 16421196 SGTC_3221 9128209 49.47 µM 0.382252632296561 0.347321371521374 no 1153 0.351136992804201 1663 16460723 SGTC_80 0159-0065 512.242 µM 0.380327036424215 0.347986058253724 no 1154 0.351851334282381 1715 1548079 SGTC_1079 idarubicin 2.36 µM 0.375603880465877 0.34961839621132 no 1155 0.353605702737615 1706 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1926 methyl fluorone black 53.6 µM 0.374601605474536 0.349965144817781 no 1156 0.353978389423853 1592 72721 Reacts with homocysteine. SGTC_2097 5376186 200 µM 0.37331951004091 0.350408882951977 no 1157 0.35445532872638 1763 742755 SGTC_1383 3049-0032 20.7 µM 0.372801954072113 0.350588068952852 no 1158 0.354647924195418 1778 712864 SGTC_2266 7929956 200 µM 0.372797455398603 0.350589626610052 no 1159 0.354649598426886 1632 2967153 SGTC_1504 k297-0033 30 µM 0.371878085605163 0.35090800934514 no 1160 0.354991811018544 1610 4388117 SGTC_1345 1488-0192 31.4 µM 0.370622606147319 0.351342957775333 no 1161 0.355459321055183 1771 658348 SGTC_2725 haloperidol 53.21 µM 0.369288420573413 0.351805386613486 no 1162 0.355956377797643 1657 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1525 8-methoxypsoralen 92.5 µM 0.368643431469063 0.352029018580379 no 1163 0.356196759226511 1841 4114 Related to psoralen; DNA damaging agent. SGTC_3168 9103419 49.47 µM 0.367195891255491 0.352531099001597 no 1164 0.356736451947913 1705 16649256 SGTC_3111 9122088 49.47 µM 0.366190623989714 0.352879928007919 no 1165 0.357111419006743 1766 16876704 SGTC_2456 5770359 74.46 µM 0.365888557591029 0.352984769611803 no 1166 0.357224117474918 1763 3118787 SGTC_1032 k061-1018 98.7 µM 0.365754373371031 0.353031346028937 no 1167 0.357274184490805 1829 4005393 SGTC_383 2324-0395 7.37 µM 0.364794968114965 0.353364427397834 no 1168 0.357632230755329 1745 3146421 SGTC_638 3970-0837 4.09 µM 0.364158702355354 0.353585384836247 no 1169 0.357869751771224 1645 4118451 YLR208W SEC13 SGTC_975 1335-0046 28.5 µM 0.363240795299295 0.353904235404852 no 1170 0.35821250777064 1576 16486740 SGTC_2081 5214970 32.255 µM 0.36269378261636 0.354094298282339 no 1171 0.358416822341064 1773 2063512 SGTC_1251 0490-5699 265 µM 0.359537841888159 0.355191557705547 no 1172 0.35959638697148 1830 3883818 SGTC_1583 clindamycin 39.6 µM 0.358764970116214 0.35546045378076 no 1173 0.359885460109864 1611 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1195 1502-0147 41.1 µM 0.358198862614093 0.355657458494141 no 1174 0.360097249175559 1660 817940 SGTC_3188 9110789 49.47 µM 0.35621295599028 0.356348856162928 no 1175 0.360840545003555 1762 849217 SGTC_1136 pergolide 1.05886 µM 0.356186027956144 0.356358234467633 no 1176 0.360850627393506 1688 47811 A dopamine receptor agonist. SGTC_2780 5215298 71.43 µM 0.355833847326122 0.356480897434998 no 1177 0.360982499705611 1849 2834131 SGTC_1366 1683-0113 21.9 µM 0.355662320414827 0.356540644882727 no 1178 0.361046733103233 1677 708623 SGTC_1896 st058441 89 µM 0.355476984471722 0.356605206345823 no 1179 0.36111614211167 1644 688759 SGTC_1888 azatryptophan 97.5 µM 0.354070466459162 0.357095298312374 no 1180 0.361643037292606 1671 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_274 sirtinol 40.1 µM 0.353836112643543 0.357176980308382 no 1181 0.361730854020495 1628 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_431 k089-0097 107 µM 0.353725866916674 0.357215407767372 no 1182 0.361772167661124 1680 5499420 SGTC_2076 5212012 200 µM 0.352922910603497 0.357495331401995 no 1183 0.362073117225168 1698 604802 SGTC_1203 3992-3522 103 µM 0.35199096814626 0.357820317852154 no 1184 0.362422517980559 1912 5322312 SGTC_1413 3910-0535 34.4 µM 0.350848291649696 0.358218932030731 no 1185 0.362851082858887 1771 2876951 SGTC_1951 sophoraflavanone G 9.2 µM 0.350640453679906 0.358291451385164 no 1186 0.362929051713138 1660 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3303 9125618 40.5795 µM 0.350587432052 0.358309952645285 no 1187 0.362948943288675 1785 22695467 SGTC_2127 5253358 187.912 µM 0.349272861810032 0.35876876240421 no 1188 0.36344223511008 1649 20612 SGTC_183 3914-0051 30.55 µM 0.348734188766034 0.358956828359555 no 1189 0.363644437376493 1845 1596232 SGTC_1389 3405-0187 19 µM 0.346309231949824 0.359803872020877 no 1190 0.364555165647496 1647 799890 SGTC_929 2805-0021 398 µM 0.346256907942307 0.35982215654048 no 1191 0.364574825149518 1721 3098024 SGTC_1758 st042942 75.2445 µM 0.346221326677021 0.359834590525611 no 1192 0.364588194167605 1758 669317 SGTC_2993 9054257 71.4286 µM 0.34388265406878 0.360652171762519 no 1193 0.365467268636373 1675 6470217 YGL055W OLE1 SGTC_1655 st012546 55.1 µM 0.342917065621665 0.360989919881253 no 1194 0.365830426420161 1724 720985 YLR208W SEC13 SGTC_466 geldanamycin 89.2 µM 0.341893208112329 0.361348168061407 no 1195 0.366215630562745 1806 5288382 HSP90 inhibitor. SGTC_3167 9103034 49.47 µM 0.341365383331071 0.36153290170627 no 1196 0.366414265875383 1730 5127859 SGTC_3236 9132701 49.47 µM 0.340660346027205 0.361779708399736 no 1197 0.366679647073614 1680 24282524 SGTC_2625 euphol 100 µM 0.340201327236594 0.361940424300029 no 1198 0.366852459372707 1844 6708538 A triterpene alcohol. SGTC_1356 1502-0781 85.8 µM 0.337488296931108 0.362890831944754 no 1199 0.367874416453987 1724 567702 SGTC_309 k408-0051 1.48 µM 0.336348354287804 0.363290420277063 no 1200 0.368304095131161 1731 3640463 SGTC_3246 9135460 32.98 µM 0.334657397207669 0.363883431760635 no 1201 0.368941771080857 1789 41446951 SGTC_3002 9075603 71.4286 µM 0.333671849933637 0.364229209556553 no 1202 0.369313596904292 1733 20105405 SGTC_3257 9139206 32.98 µM 0.333622556751175 0.364246506901316 no 1203 0.369332197377529 1800 4910041 SGTC_2063 5246145 200 µM 0.333454475554294 0.364305489923566 no 1204 0.369395624062551 1767 711240 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.333331051551597 0.364348803898009 no 1205 0.369442201288248 1701 16486 A toxic proline analog. SGTC_3289 9119912 71.43 µM 0.333140501106099 0.364415678385907 no 1206 0.369514114168466 1755 17014829 SGTC_110 0850-0284 111.64 µM 0.332507316790554 0.364637926743235 no 1207 0.369753107854261 1724 3906265 SGTC_2137 5261020 140 µM 0.332190691499493 0.364749079622517 no 1208 0.369872636082181 1731 763655 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.332140473249229 0.364766710033306 no 1209 0.36989159497295 1880 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_376 3970-0862 59.1 µM 0.330804115258173 0.36523597789761 no 1210 0.370396226107228 1828 3135186 SGTC_1121 fusaric acid 630.51 nM 0.330219956181084 0.365441171320293 no 1211 0.370616884481837 1690 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2186 6124449 200 µM 0.32551423295324 0.367095517735075 no 1212 0.372395956167639 1810 3834182 YLR033W RSC58 SGTC_2243 6634756 200 µM 0.325078287281054 0.367248904528909 no 1213 0.37256091076389 1852 885676 SGTC_2781 5567276 71.43 µM 0.321578506878663 0.368481062630491 no 1214 0.37388601431474 1801 2853274 SGTC_2928 9011484 9.79 µM 0.321104995656776 0.368647874668385 no 1215 0.374065412316316 1732 2994751 SGTC_2125 5246583 200 µM 0.320804941119081 0.368753592916834 no 1216 0.374179107344012 1901 835267 SGTC_2479 5617353 43.85 µM 0.319978399756242 0.369044859669918 no 1217 0.374492352456731 1805 2731746 SGTC_2707 st078556 66.6 µM 0.319031292652606 0.369378705317307 no 1218 0.374851391789484 1888 17250899 SGTC_632 0781-2353 4.65 µM 0.317696758481096 0.36984928224902 no 1219 0.375357485144559 1802 6811515 YHR007C ERG11 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.316364169141803 0.370319367949131 no 1220 0.375863055112852 1798 6708630 An antioxidant. SGTC_1529 apigenin 74 µM 0.316107555154451 0.37040991365324 no 1221 0.375960436185435 1865 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_271 rotenone 740 µM 0.31522234319732 0.370722313901725 no 1222 0.376296421137435 1833 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3012 9080433 71.4286 µM 0.314583794745277 0.370947717045488 no 1223 0.37653884241688 1893 17688859 SGTC_667 1498-1044 59 µM 0.313912386853606 0.371184767107227 no 1224 0.376793791119088 1773 6739982 SGTC_2684 capsaicin 100 µM 0.313613983262817 0.371290138415014 no 1225 0.37690711894094 1788 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_276 colchicine 750 µM 0.31279001941693 0.371581143934859 no 1226 0.377220099271547 1784 2833 A microtubule depolymerizer. SGTC_1240 0356-0016 42.1 µM 0.312130874524745 0.371813991962004 no 1227 0.377470531681127 1796 4305613 SGTC_1882 5615643 20 µM 0.311986078971966 0.371865148395593 no 1228 0.377525551528759 1799 2253075 SGTC_2616 abietic acid 100 µM 0.309904441756189 0.372600842832394 no 1229 0.3783168124788 1942 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_778 3456-2434 196 µM 0.308473210861387 0.373106939944136 no 1230 0.378861140825381 1914 5539063 SGTC_3318 9139014 38.6185 µM 0.308248023230573 0.373186588436933 no 1231 0.378946806507144 1773 16643984 SGTC_264 promethazine 12.5 mM 0.307044780147463 0.373612265294284 no 1232 0.379404643869766 1881 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1441 4106-0040 13 µM 0.307028420750753 0.373618053897491 no 1233 0.37941086983311 1773 2904180 SGTC_1207 2099-0101 141 µM 0.306783149463827 0.373704844021419 no 1234 0.379504217490576 1890 5837381 SGTC_1883 5-benzylidenerhodanine 20 µM 0.305968668944335 0.373993096798981 no 1235 0.379814250524702 1894 1273210 SGTC_1295 1013-0063 9.78 µM 0.303047613485661 0.375027466041577 no 1236 0.380926788144043 1897 6826038 SGTC_748 act1.228 77.9 µM 0.299768057585185 0.37618985484239 no 1237 0.382177040898869 1701 4421505 YNR035C ARC35 SGTC_1418 3966-3099 2.4 µM 0.299319204436079 0.376349031704957 no 1238 0.382348251440684 1849 740335 SGTC_2324 6149169 200 µM 0.299037338769739 0.376449000522861 no 1239 0.382455778038835 1858 2888231 SGTC_116 0155-0182 31.788 µM 0.298360906862912 0.37668894327867 no 1240 0.382713861404096 1757 771486 SGTC_3129 9127257 49.47 µM 0.2981765935371 0.376754330846202 no 1241 0.382784192674167 1663 837894 SGTC_532 1548-0774 215 µM 0.29764954309563 0.37694132840119 no 1242 0.382985328738584 1901 5932993 SGTC_3275 9138069 49.47 µM 0.296914079909616 0.377202319063101 no 1243 0.383266053219762 1828 17617007 SGTC_1080 nisoldipine 24.4 µM 0.296012265767906 0.377522418538254 no 1244 0.383610357112656 1775 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2400 5203494 178.7 µM 0.295456813448844 0.377719618565388 no 1245 0.38382246918269 1732 6777674 SGTC_837 0091-0265 12.5 µM 0.293931566535825 0.378261284707764 no 1246 0.384405098189353 1768 759367 SGTC_1850 st056238 17 µM 0.292326398021285 0.378831592164945 no 1247 0.38501853857718 1786 5393177 SGTC_570 0987-0065 62.6 µM 0.29155754553142 0.379104854745405 no 1248 0.385312469715707 1908 3104428 SGTC_268 camptothecin 39.6153 µM 0.288539922584941 0.380177949439325 no 1249 0.386466737745775 1799 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1272 0839-0021 27 µM 0.288102436348299 0.380333600401066 no 1250 0.386634163861603 1823 5027250 SGTC_3021 9087658 49.47 µM 0.286498504533765 0.380904420577166 no 1251 0.387248169349576 1907 25237042 SGTC_2628 lathosterol 100 µM 0.284830560062372 0.38149829712431 no 1252 0.387886979010427 1807 6710616 SGTC_2335 9018011 154.17 µM 0.284389044682194 0.381655546752103 no 1253 0.388056126819937 1909 6458208 SGTC_2116 5511452 16.8835 µM 0.283399725797439 0.382007972353525 no 1254 0.388435219278556 1830 870744 SGTC_2744 captopril 92.04 µM 0.283053811854075 0.38213122055496 no 1255 0.38856779351803 1925 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2581 avocatin a 64 µM 0.281764209495 0.38259080756504 no 1256 0.389062158057615 1797 6710728 A skin care supplement. SGTC_54 0159-0055 9 µM 0.278969514443915 0.383587344613937 no 1257 0.390134110152238 1932 3319099 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.278588849325268 0.383723142591094 no 1258 0.390280185501591 1750 4330530 SGTC_2176 5809774 33.9695 µM 0.277235830725846 0.384205932167325 no 1259 0.390799514264372 1956 2870539 SGTC_557 1315-0110 16.2 µM 0.275129025617465 0.384958048446778 no 1260 0.391608556272304 1773 6833801 SGTC_2877 9040724 71.43 µM 0.271015749644055 0.386427708096288 no 1261 0.393189459481023 1975 6463895 SGTC_249 wiskostatin 11.211 µM 0.270664666710278 0.386553224674429 no 1262 0.39332447729525 1919 2775510 A n-wasp and actin depolymerizer. SGTC_1880 MG-132 525 µM 0.269242376547857 0.387061832669798 no 1263 0.393871586036634 1927 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1714 st033236 13.627 µM 0.26684997974761 0.387917785926443 no 1264 0.394792335393046 1910 2916566 SGTC_655 k060-0012 42 µM 0.266555458790021 0.388023197573747 no 1265 0.394905726895822 1813 5994525 SGTC_454 lyso-paf C-16 6.67 µM 0.265122530402463 0.388536172871439 no 1266 0.395457535720702 1746 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2823 7987624 58.44 µM 0.265098254515471 0.388544865095232 no 1267 0.395466885972372 1849 2239440 SGTC_2561 acetosyringone 100 µM 0.265035480964472 0.388567342050859 no 1268 0.395491064502795 1934 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1333 1482-0047 286 µM 0.264876739404764 0.388624183370645 no 1269 0.395552208889647 1948 3811116 SGTC_1424 4048-1941 275 µM 0.264253332544609 0.388847432592338 no 1270 0.395792358833497 1962 X1424 SGTC_2418 pentamidine 31.67 µM 0.263515693267042 0.38911163717892 no 1271 0.396076564697537 1949 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_548 1436-0017 110 µM 0.263139933920149 0.389246244830942 no 1272 0.396221362687189 1949 9677137 SGTC_2979 9012552 45.46 µM 0.261995430768935 0.389656320145874 no 1273 0.396662482452311 1995 17100905 SGTC_3351 9150312 21.596 µM 0.259694664788988 0.390481055635703 no 1274 0.397549654183873 1920 4904905 SGTC_2211 7117706 200 µM 0.25898494278684 0.39073556315782 no 1275 0.397823429081545 1937 822771 SGTC_711 k292-0785 179 µM 0.256612484536334 0.391586669966701 no 1276 0.398738968200261 1835 4146315 SGTC_3120 9124077 49.47 µM 0.255770654147997 0.391888797169128 no 1277 0.399063967469562 1982 18774327 YGL155W CDC43 SGTC_3119 9125183 49.47 µM 0.255403720523242 0.392020507567766 no 1278 0.399205648749736 1970 22695334 SGTC_479 n-linoleoylglycine 10 µM 0.253815997258271 0.392590561421146 no 1279 0.39981885702289 1855 6433346 An anti-infammatory. SGTC_3186 9110464 49.47 µM 0.253543025934008 0.392688591904399 no 1280 0.399924308568798 1937 17018021 SGTC_2659 sanguinarine 24.21 µM 0.251415517431175 0.393452863566435 no 1281 0.400746435874333 1867 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1701 st028638 40.4 µM 0.249579959509289 0.394112587066659 no 1282 0.401456099105799 1945 3490878 SGTC_1539 benzyladenosine 56 µM 0.248813775853279 0.394388053504556 no 1283 0.401752417284554 1865 92208 A nucleotide analog. SGTC_1978 st071761 42 µM 0.248740878844987 0.394414264960971 no 1284 0.40178061282956 1815 5147680 SGTC_84 0443-0269 128.823 µM 0.24662677306352 0.395174638005281 no 1285 0.402598541274283 1958 6150058 SGTC_2225 6654152 15.4 µM 0.245589402595478 0.395547891650741 no 1286 0.403000046770883 1938 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3238 9133470 49.47 µM 0.244559895901351 0.39591841059693 no 1287 0.403398609804206 1993 3534688 SGTC_516 3992-2719 87.3 µM 0.24452935471157 0.395929403794143 no 1288 0.403410435049608 1746 5350887 YDR037W KRS1 SGTC_1626 st003712 1.76 µM 0.24421214279605 0.396043588035514 no 1289 0.403533261573522 1909 24207035 SGTC_1350 1495-0454 146 µM 0.243959425687222 0.396134562980631 no 1290 0.403631122098015 1958 1069057 SGTC_2667 digitoxin 100 µM 0.242226027379125 0.396758716547521 no 1291 0.404302514261645 2007 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_738 1315-0003 72.4 µM 0.241543781678912 0.397004448890514 no 1292 0.404566843952293 1967 6251474 SGTC_2055 5235184 200 µM 0.240518321284177 0.397373877756062 no 1293 0.404964230865269 1883 2836034 SGTC_49 0717-0965 32.132 µM 0.240475215239994 0.397389409011534 no 1294 0.404980937490188 1963 5889349 YGL099W LSG1 SGTC_1423 4048-0112 5.59 µM 0.239748807253769 0.397651160750937 no 1295 0.405262497718208 1978 X1423 SGTC_2094 5332512 191.667 µM 0.238372388267096 0.398147261870018 no 1296 0.405796140611413 1963 755774 SGTC_540 1187-0821 17.3 µM 0.235126697528404 0.399317753210235 no 1297 0.40705519892251 1812 847520 SGTC_175 3793-3120 23.7 µM 0.232525486254465 0.4002564806827 no 1298 0.408064947221414 1866 5322297 SGTC_1327 1436-0082 2.18 µM 0.232440380809522 0.40028720338192 no 1299 0.408097994139957 1894 15992205 SGTC_1296 1068-0102 11.9 µM 0.231361351159307 0.400676781885037 no 1300 0.408517043978519 1990 767053 SGTC_1520 flindersine 88 µM 0.231053726368485 0.400787866465337 no 1301 0.40863653172531 2021 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_21 0849-0113 22.993 µM 0.230625693746298 0.400942444156533 no 1302 0.408802802459126 1873 1560156 SGTC_3053 9095903 49.47 µM 0.230354510366388 0.401040386076462 no 1303 0.408908153064968 2007 17174018 SGTC_477 mead ethanolamide 10 µM 0.227819394017315 0.401956281191133 no 1304 0.409893324438455 1975 16061185 SGTC_1680 diphenhydramine 100 µM 0.224977251251704 0.402983740137976 no 1305 0.410998485752467 1864 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1994 st072947 40.9 µM 0.224961660654761 0.40298937812713 no 1306 0.411004550080919 1930 5286565 YDL195W SEC31 SGTC_2082 5219693 150 µM 0.2248223028568 0.403039774639972 no 1307 0.4110587575105 1905 2834649 SGTC_2393 9031399 185.94 µM 0.22289150881745 0.403738180741528 no 1308 0.411809972572849 1975 1526623 YDL150W RPC53 SGTC_123 0083-0120 66.675 µM 0.222349948688805 0.403934128902548 no 1309 0.412020735843148 1824 16001701 SGTC_3074 9116018 49.47 µM 0.222051397251997 0.404042161578085 no 1310 0.412136936341057 1912 17027303 SGTC_2040 5100729 123 µM 0.218267859818988 0.405411889353766 no 1311 0.413610207444545 1952 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2367 9070478 135.38 µM 0.217174792419641 0.405807821520045 no 1312 0.414036064305334 1886 572802 SGTC_297 0986-0032 24 µM 0.214997857035297 0.406596640353093 no 1313 0.414884494666496 1917 2847425 SGTC_854 0422-0053 192 µM 0.213707502804774 0.407064383131434 no 1314 0.415387580058888 2005 3596728 SGTC_1216 1165-0504 9.65 µM 0.213682078287546 0.407073600643497 no 1315 0.415397494007227 2043 6304004 SGTC_382 3229-0966 23.2 µM 0.213223854972818 0.407239735681045 no 1316 0.415576181249186 2011 5722370 SGTC_2798 7813637 45.45 µM 0.21310271982525 0.40728365765146 no 1317 0.415623421628321 1947 956368 SGTC_2531 methyl deoxycholate 70.07 µM 0.213034408178222 0.407308427047279 no 1318 0.415650062395404 1893 16667744 Haematoxylin. SGTC_1613 st002381 52.1 µM 0.212614125170973 0.407460827310787 no 1319 0.415813976524343 2077 551167 SGTC_2 0422-0095 29 µM 0.212504600211231 0.407500544834017 no 1320 0.415856694644554 1950 6790840 SGTC_1114 scopoletin 1.73284 µM 0.212092360502572 0.407650045674708 no 1321 0.416017489784962 2043 5280460 A coumarin with genotoxic properties. SGTC_2594 a-mangostin 100 µM 0.211517198475499 0.407858653597653 no 1322 0.416241856673817 2027 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.211092144228945 0.408012835092243 no 1323 0.416407685058647 2010 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_429 1112-0049 25.5 µM 0.210418032903033 0.408257387181593 no 1324 0.416670709737646 1854 2836170 SGTC_614 0462-0418 107 µM 0.207582198418425 0.409286553052292 no 1325 0.417777602599787 1987 5188303 SGTC_1877 wortmannin 25 µM 0.206806611768216 0.409568134045423 no 1326 0.418080446167213 2049 312145 A covalent inhibitor of PI 3-kinase. SGTC_816 0325-0417 81.3 µM 0.205629689133952 0.409995511341492 no 1327 0.418540092256638 1912 68101 SGTC_1523 st012844 44.7 µM 0.205062725514995 0.410201431703681 no 1328 0.418761559138135 1941 4274103 SGTC_3136 9095672 49.47 µM 0.204395011215683 0.410443976317485 no 1329 0.419022414185935 2095 17217380 SGTC_749 1000-0129 128 µM 0.203235812143212 0.410865132165385 no 1330 0.419475361422432 2048 708470 SGTC_1414 3917-0015 5.4 µM 0.202271781420753 0.411215458481775 no 1331 0.419852129584094 2017 6618702 SGTC_3016 9080866 49.47 µM 0.201832277787741 0.411375196503555 no 1332 0.420023923385923 1963 17066299 SGTC_1507 4075-3230 155 µM 0.201819756729051 0.41137974750986 no 1333 0.420028817858477 2081 659771 SGTC_2718 lomofungin 53.02 µM 0.201291843870913 0.411571637873827 no 1334 0.420235189847855 2034 5351222 A RNA synthesis inhibitor. SGTC_1160 4092-0570 10.5 µM 0.201063985470202 0.411654468368117 no 1335 0.420324271160206 1865 4994975 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.200848244173139 0.411732897713126 no 1336 0.420408619048698 1981 521171 SGTC_2226 7298446 200 µM 0.197812996742596 0.412836686456731 no 1337 0.421595688586777 2053 3283010 SGTC_1411 3909-8223 150 µM 0.197713459655509 0.412872895531674 no 1338 0.421634629156414 2056 X1411 SGTC_767 0929-0023 86 µM 0.197150185723545 0.413077814301128 no 1339 0.421855005747206 2051 1204563 SGTC_2824 7998404 51.95 µM 0.196977490375674 0.41314064552726 no 1340 0.421922576378114 1966 837851 SGTC_1332 1480-0653 17.5 µM 0.196146030898829 0.413443184028561 no 1341 0.422247934255822 2087 5749438 SGTC_2949 9072542 2.23 µM 0.195234232185763 0.413775014199471 no 1342 0.422604790625876 1929 16457352 SGTC_1771 st048882 4.1505 µM 0.194953254979721 0.413877282430736 no 1343 0.422714771252424 1868 4580403 SGTC_1045 1348-1485 165 µM 0.194418185508104 0.414072049637257 no 1344 0.422924225804879 2060 6810614 SGTC_1053 3366-3204 134 µM 0.193703006210589 0.414332410463771 no 1345 0.423204218906519 1894 3632071 YPR165W RHO1 SGTC_3187 9109394 49.47 µM 0.192289119718209 0.414847246137009 no 1346 0.423757870289208 1919 17098090 SGTC_2084 5306078 60.6385 µM 0.189656494436689 0.415806247876396 no 1347 0.424789157185492 2010 679340 SGTC_865 0488-0499 301 µM 0.188685547997625 0.416160067110398 no 1348 0.42516963957642 2113 9634651 SGTC_908 3448-7491 47.7 µM 0.188558413963285 0.416206400621929 no 1349 0.425219464446508 1957 1203031 SGTC_552 k242-0005 476 µM 0.188394180268745 0.416266256686173 no 1350 0.425283830745506 1964 4088318 SGTC_2170 morpholine 200 µM 0.18717768519186 0.416709676798755 no 1351 0.425760660130907 2036 121171 Reacts with secondary amines. SGTC_2923 7992654 58.14 µM 0.186411318649328 0.41698907668526 no 1352 0.426061108499398 1947 2985126 SGTC_790 1575-0012 79.1 µM 0.186159362780221 0.417080943255157 no 1353 0.426159895329741 2086 378741 YLR208W SEC13 SGTC_315 k915-0449 187 µM 0.18587914417172 0.417183120125458 no 1354 0.426269768854074 2015 20970215 YNL149C PGA2 SGTC_955 1216-0110 33 µM 0.185493759050157 0.417323653281118 no 1355 0.426420887442397 1956 3619719 SGTC_1281 0884-0031 11.8 µM 0.185466590693731 0.417333560795244 no 1356 0.426431541203111 1945 1548255 SGTC_747 3448-8087 38.7 µM 0.184656771769948 0.417628902415993 no 1357 0.426749127060664 1932 5168703 SGTC_2819 7996655 46.38 µM 0.184533078975759 0.417674017373882 no 1358 0.426797639723261 2046 6456960 SGTC_292 k038-0015 474 µM 0.183937070869336 0.417891416927327 no 1359 0.427031411292664 2056 46368540 SGTC_3276 9139060 49.47 µM 0.181359079277387 0.418832051760466 no 1360 0.428042868107466 2027 4870619 SGTC_2898 9056270 58.44 µM 0.180663178977197 0.419086045518415 no 1361 0.428315981027473 1997 19154699 SGTC_1620 st003704 16.5 µM 0.17824072895429 0.419970467864636 no 1362 0.429266962367986 2094 2834414 SGTC_1759 st043059 70 µM 0.177702970972193 0.420166855156898 no 1363 0.429478125944439 1929 669426 SGTC_1915 st067105 30.6 µM 0.174189048851892 0.421450614119296 no 1364 0.430858445860952 2053 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2664 lyso-paf C-16 73.48 µM 0.17299550914641 0.421886846774183 no 1365 0.431327478792684 2063 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1773 st048542 73.5835 µM 0.172899753710939 0.421921849056959 no 1366 0.431365112624139 1927 3237138 SGTC_1812 st052057 4.327 µM 0.172496909837878 0.42206911068947 no 1367 0.431523445270797 2029 3645418 SGTC_2497 7-hydroxyflavone 100 µM 0.171313480516149 0.422501782262573 no 1368 0.431988640618319 2105 5281894 SGTC_2526 patulin 37.61 µM 0.167329420699566 0.423959072051311 no 1369 0.433555428050405 2019 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3171 9103192 49.47 µM 0.167308724933527 0.423966644884209 no 1370 0.433563569699661 2148 13018434 SGTC_2533 agelasine 13.65 µM 0.166956394693172 0.424095571116445 no 1371 0.433702179630339 2124 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3227 9130768 49.47 µM 0.166321564282958 0.424327891550859 no 1372 0.433951948275095 2057 17720899 SGTC_3327 9140648 26.9345 µM 0.16458433641036 0.424963775911966 no 1373 0.434635580404328 2110 8029710 SGTC_46 0329-0187a 2.197 µM 0.164393078941519 0.425033794600059 no 1374 0.434710855829496 2039 46494817 SGTC_1558 st069300 45.6 µM 0.163215985411924 0.425464776396301 no 1375 0.435174190218895 2122 24208000 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.163030098800369 0.425532845199281 no 1376 0.435247368141702 2105 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1922 5578187 25 µM 0.160912503840685 0.426308431906715 no 1377 0.436081157001284 2116 1350412 SGTC_3189 9110682 49.47 µM 0.160287105510828 0.426537543895328 no 1378 0.436327457930246 1992 17122418 SGTC_2340 7987427 183.45 µM 0.158852920057602 0.427063045062222 no 1379 0.436892376969431 2041 2239331 SGTC_2920 7982904 15.77 µM 0.158366500782236 0.427241303828579 no 1380 0.437084004567572 2016 6456808 SGTC_1796 st049173 110.4 µM 0.158192487360158 0.427305078385918 no 1381 0.43715256171737 2122 94134 SGTC_2900 5328528 85.29 µM 0.157137698897771 0.42769169070291 no 1382 0.43756816360328 2080 795359 SGTC_2017 5132927 60.65 µM 0.153385876662753 0.429067408863268 no 1383 0.439046990941027 2032 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1312 1218-2183 165 µM 0.152717257659459 0.429312669064694 no 1384 0.439310625382873 2156 6744073 SGTC_219 mitoxanthrone 164.414 µM 0.150425186577195 0.430153644151573 no 1385 0.44021458566687 2106 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1198 1612-1005 86.7 µM 0.150376861686611 0.430171378278434 no 1386 0.440233647689155 2125 6998509 SGTC_1934 st074720 32.6 µM 0.149876296628253 0.430355082458007 no 1387 0.440431106505693 2096 17250992 SGTC_2470 5664817 21.68 µM 0.149294175614642 0.430568736108747 no 1388 0.440660755477799 2180 2859561 SGTC_547 1120-0019 610 nM 0.149156445346178 0.430619289698548 no 1389 0.440715093519502 2033 3676939 SGTC_1248 0469-0687 58.6 µM 0.148886045841721 0.430718542544063 no 1390 0.440821776144953 2072 4017482 SGTC_1982 st072467 71.9 µM 0.147715595483562 0.431148218460431 no 1391 0.441283611622982 1998 3163533 SGTC_2518 prenyletin 46.28 µM 0.146662562182563 0.431534859876774 no 1392 0.441699185019789 2131 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2603 homopterocarpin 100 µM 0.145024349211809 0.432136491546536 no 1393 0.442345823564771 2033 101795 A weak amylase inhibitor. SGTC_2341 7987486 176.74 µM 0.144533024357275 0.432316960733963 no 1394 0.442539790275487 2151 1258686 SGTC_2870 9038528 12.99 µM 0.143956584125021 0.43252871176571 no 1395 0.442767376649504 2066 6463316 SGTC_273 hydroxyurea 18.1 mM 0.143853588332384 0.432566548546458 no 1396 0.442808042767686 2059 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_574 1315-0397 40 µM 0.143420845414037 0.432725528773075 no 1397 0.442978910449043 2129 6794277 SGTC_213 1246-0773 967 nM 0.141359674924328 0.43348290649672 no 1398 0.443792904534196 2086 6251622 SGTC_2144 5628481 200 µM 0.140715966964316 0.433719487380781 no 1399 0.444047165397637 2045 2818399 SGTC_140 0062-0056 502.533 µM 0.13831478556325 0.434602198317834 no 1400 0.444995820316858 2126 3758964 SGTC_2834 9001755 58.44 µM 0.137342888184887 0.434959575590017 no 1401 0.445379885872225 2015 2989575 SGTC_1484 3473-2379 286 µM 0.135945031030016 0.435473676030289 no 1402 0.445932368141142 2166 671917 SGTC_2860 9025725 38.96 µM 0.13549400758341 0.435639575632187 no 1403 0.446110650912103 1975 40546248 SGTC_19 0279-0214 38.434 µM 0.133996955931627 0.436190316007812 no 1404 0.446702490771217 2164 3566274 YBR002C RER2 SGTC_2092 5303694 80.6725 µM 0.133938051176329 0.436211988623637 no 1405 0.446725780434894 2049 1963699 SGTC_3170 9103054 49.47 µM 0.133874074680325 0.436235527483829 no 1406 0.44675107556309 2057 16432970 SGTC_1270 0831-1170 17.3 µM 0.133594417353129 0.436338424401965 no 1407 0.446861649461525 2153 6764716 SGTC_3201 9113999 49.47 µM 0.133266953433332 0.436458916719372 no 1408 0.446991130890978 2109 16649224 SGTC_2448 5185112 27.17 µM 0.133241560641766 0.436468260396123 no 1409 0.447001171607268 2046 5718189 SGTC_3240 9133527 49.47 µM 0.133236487405492 0.436470127177394 no 1410 0.447003177650179 2063 17617455 SGTC_598 3937-0236 20.2 µM 0.133125362188176 0.436511017895583 no 1411 0.447047118769318 2128 1379313 SGTC_3041 9091929 49.47 µM 0.132279255147673 0.436822381908035 no 1412 0.447381707585365 2123 25236887 SGTC_3287 9117173 37.0625 µM 0.130663688724638 0.437417012465933 no 1413 0.448020679107101 2198 2789709 SGTC_2942 9052777 62.25 µM 0.12963717154008 0.437794909215331 no 1414 0.448426746376334 2102 6469503 SGTC_1206 3978-0017 132 µM 0.12701719787235 0.438759669261657 no 1415 0.44946339343157 2089 3873677 SGTC_2685 mycophenolic acid 18.85 µM 0.125313865231828 0.439387087684258 no 1416 0.450137537921673 2164 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2763 lisinopril 49.32 µM 0.124757410217732 0.439592089610638 no 1417 0.450357802803185 2207 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2416 tofa 880 nM 0.124248285299506 0.439779668990987 no 1418 0.450559346130459 1910 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_697 0508-1955 564 µM 0.124194470895873 0.43979949688533 no 1419 0.450580649966411 2189 6243113 SGTC_418 lividomycin a 100 µM 0.123855593213952 0.439924359691785 no 1420 0.450714806808624 2201 72394 An antibiotic. SGTC_338 4055-0136 114 µM 0.123842389605372 0.439929224811927 no 1421 0.450720034043062 2161 2900563 SGTC_2441 5730946 39.09 µM 0.122334359844176 0.440484946495877 no 1422 0.451317110565456 2124 1774275 SGTC_2320 7373003 200 µM 0.121928072633123 0.44063468685353 no 1423 0.451477991373631 2068 5415828 SGTC_846 0335-0850 148 µM 0.121676247107999 0.440727503400941 no 1424 0.45157771275073 2196 6819598 SGTC_530 4358-1714 28 µM 0.120795735732936 0.44105206328763 no 1425 0.451926413882332 2125 1564641 SGTC_906 1165-0455 526 µM 0.12009119309908 0.441311788945639 no 1426 0.4522054543951 2183 3252859 SGTC_3103 9120822 49.47 µM 0.120076640932375 0.441317153786047 no 1427 0.452211218162309 2183 17141819 SGTC_1112 tnp00069 1.16933 µM 0.119849822476632 0.441400774671289 no 1428 0.452301056860433 2173 145826 SGTC_1219 1469-0211 33.1 µM 0.118106501203346 0.442043569734573 no 1429 0.452991636146928 2200 6822282 SGTC_2181 6316240 54.2555 µM 0.116100232205221 0.44278350734001 no 1430 0.45378655239315 2088 12779990 SGTC_1036 k216-0215 33.5 µM 0.115963858426831 0.442833811003866 no 1431 0.453840592648303 2203 622330 SGTC_415 dibenzyl ketone 100 µM 0.115284048272595 0.443084583655316 no 1432 0.454109990845692 2174 7593 SGTC_3157 9099274 49.47 µM 0.11498419757592 0.44319520172107 no 1433 0.454228823733615 2207 17217662 SGTC_1064 honokiol 6.76 µM 0.114393738409484 0.443413041233095 no 1434 0.454462838719416 2094 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3099 9120367 49.47 µM 0.112222826951209 0.444214107325494 no 1435 0.455323365101921 2209 24824940 SGTC_3084 9116877 49.47 µM 0.109518383581911 0.445212365147769 no 1436 0.456395670740803 2228 27241325 SGTC_2786 7743617 45.45 µM 0.108199389929835 0.445699355472688 no 1437 0.456918764440731 2084 583674 SGTC_2354 9060492 162 µM 0.108013797814413 0.445767885188527 no 1438 0.456992373586814 2183 6471895 SGTC_2087 5276107 200 µM 0.107684500404399 0.445889481937182 no 1439 0.457122982448354 2202 144405 SGTC_3067 9117431 49.47 µM 0.106952556481568 0.446159778623075 no 1440 0.457413309111688 2099 17150885 SGTC_1438 4092-1045 4 µM 0.105518479699294 0.446689435607111 no 1441 0.457982203582868 2221 1351342 SGTC_717 1532-0246 73.2 µM 0.104610939959403 0.447024672414379 no 1442 0.45834226675418 2123 9561992 SGTC_3237 9133362 49.47 µM 0.104544499484906 0.447049216402748 no 1443 0.458368628123189 2226 43845137 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.104452476955695 0.447083211074787 no 1444 0.458405139902494 2231 688801 SGTC_1828 st055811 49 µM 0.103567063740151 0.447410317458863 no 1445 0.458756463196321 2224 5877589 SGTC_1893 st059353 36.1 µM 0.102345358057443 0.44786172216543 no 1446 0.459241276888091 2079 3112488 SGTC_300 r073-0011 5.04 µM 0.0995631994318073 0.448889945464962 no 1447 0.460345555602619 2249 2735780 SGTC_3055 9094636 49.47 µM 0.0979051000922348 0.449502905461409 no 1448 0.461003825079221 2200 25236176 SGTC_1440 4100-1550 40 µM 0.0977565874426933 0.449557812967511 no 1449 0.461062790204113 2208 742806 SGTC_808 0711-0032 135 µM 0.0959703075827695 0.450218304623185 no 1450 0.461772077400512 2238 4252555 SGTC_2190 6049624 200 µM 0.0958012522971621 0.450280821376191 no 1451 0.461839211373481 2214 2265554 SGTC_669 0108-0021 26.2 µM 0.0952886913789957 0.450470374266885 no 1452 0.46204276237675 2284 17201 SGTC_2159 5658611 73.75 µM 0.0928914381436857 0.451357064587148 no 1453 0.462994903854608 2248 793844 SGTC_2551 apiole 73.87 µM 0.0922946996212881 0.451577822718595 no 1454 0.46323194974326 2246 10659 A possible DNA adduct former. SGTC_2651 TUB2.036 5 µM 0.0914631278739643 0.451885480281545 no 1455 0.463562301544956 2241 15992207 YFL037W TUB2 SGTC_784 4579-0127 173 µM 0.0900335266642922 0.452414458938403 no 1456 0.464130286291051 2252 1948547 SGTC_2188 6126565 140.678 µM 0.0892367331410391 0.452709323872304 no 1457 0.464446886494512 2225 874518 SGTC_33 0986-0033 35.816 µM 0.0884344774460131 0.453006236511216 no 1458 0.464765679796489 2256 2848082 SGTC_1118 chelidonine 707.474 nM 0.0875802649491943 0.453322407099638 no 1459 0.465105144092842 2254 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_734 2023-0417 80 µM 0.0869921407465922 0.453540107354 no 1460 0.465338879600377 2220 3935732 SGTC_692 k241-0027 77.8 µM 0.0865356040725053 0.453709108753155 no 1461 0.465520327127972 2241 3600480 SGTC_88 0180-0332 8.668 µM 0.0863108620006088 0.453792307175816 no 1462 0.465609652036031 2268 3101745 SGTC_2350 9023895 38.85 µM 0.0858316434579181 0.453969718318558 no 1463 0.465800125724771 2196 2997209 SGTC_578 3460-0051 92 µM 0.0847633872362324 0.454365229671924 no 1464 0.466224750749714 2260 2876744 SGTC_895 0964-0006 13.7 µM 0.0847111217223107 0.454384581628458 no 1465 0.466245526948232 2245 6738897 SGTC_2830 7992007 71.43 µM 0.0842252789547905 0.454564476130766 no 1466 0.466438659947418 2219 1952075 SGTC_1555 citronellol 128 µM 0.083698313533589 0.454759607780321 no 1467 0.466648149023598 2261 8842 A terpine precursor. SGTC_1683 st010134 710 nM 0.0822998397424444 0.455277505756297 no 1468 0.467204140928315 2247 3818134 SGTC_3198 9112019 49.47 µM 0.0812000268789724 0.455684853822301 no 1469 0.46764143907098 2236 45595555 SGTC_1568 digitonin 820 nM 0.0810505051803243 0.455740237191498 no 1470 0.467700893631689 2275 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_394 menadione 8.33 µM 0.0810153606318737 0.455753254982168 no 1471 0.467714868321335 2280 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3060 1327-0027 12.5 µM 0.0802246823578172 0.456046140367458 no 1472 0.468029279872062 2264 16000455 YPR107C YTH1 SGTC_1127 asiatic acid 681.4 nM 0.0801978608419098 0.456056076092484 no 1473 0.46803994574224 2177 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2486 5283202 22.39 µM 0.0794847766976647 0.456320240048113 no 1474 0.468323519867987 2147 1377751 SGTC_885 0865-0106 16.8 µM 0.0787682001931683 0.456585717207317 no 1475 0.46860849900149 2238 2793380 SGTC_2388 9080168 200 µM 0.078704779228236 0.456609214332398 no 1476 0.468633722000392 2256 15943073 SGTC_1958 st076513 41.9 µM 0.078389389393788 0.456726066814902 no 1477 0.468759156798151 2205 732122 YGL099W LSG1 SGTC_2652 actinonin 100 µM 0.0782640665123164 0.456772500200038 no 1478 0.468809000262762 2284 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_972 1319-0219 195 µM 0.0776544339653156 0.45699838358342 no 1479 0.469051470512837 2171 23903702 SGTC_198 3454-2873 16.191 µM 0.0768708465313889 0.457288741793735 no 1480 0.469363145000117 2204 710957 SGTC_1141 3253-0389 52.6 µM 0.0759382094249318 0.457634360045142 no 1481 0.469734128941348 2256 5402031 SGTC_2318 6029776 164 µM 0.0756011193794365 0.457759287346621 no 1482 0.469868222939536 2236 818325 SGTC_2241 6772625 37.8075 µM 0.075428853428903 0.457823131604448 no 1483 0.469936751439434 2289 2285411 SGTC_869 0564-0080 44.1 µM 0.0745200460054297 0.458159966783572 no 1484 0.470298295553545 2122 6843321 SGTC_613 3914-0030 117 µM 0.0744024028754835 0.458203571561369 no 1485 0.470345098443337 2251 1145395 SGTC_1752 st044819 83.042 µM 0.0738744719755743 0.458399256913738 no 1486 0.470555134372021 2206 441209 YML126C ERG13 SGTC_348 k064-0012 10.7 µM 0.0728506127204671 0.458778794101364 no 1487 0.470962497397349 2262 5066323 SGTC_924 2046-0044 21.3 µM 0.069997830242586 0.459836496990693 no 1488 0.472097693309371 2297 3623589 SGTC_2332 7982454 138.89 µM 0.0694721463956733 0.460031431745801 no 1489 0.472306901514228 2277 2981748 SGTC_2939 9044578 71.43 µM 0.0690073981682534 0.460203778279809 no 1490 0.472491865326638 2273 2653634 SGTC_2553 4-methylesculetin 85.09 µM 0.0677934247045157 0.460654001566896 no 1491 0.472975039023762 2265 5319502 SGTC_1297 1068-0111 14.1 µM 0.0671457451109939 0.460894225542003 no 1492 0.473232838355049 2236 767057 SGTC_1314 1222-0010 41.1 µM 0.0663686437231607 0.461182470809915 no 1493 0.473542166913627 2233 3526027 SGTC_991 3996-0057 64.7 µM 0.0659832780833437 0.461325419605927 no 1494 0.473695569297514 2226 715343 SGTC_225 nsc-122657 1.016 µM 0.0645313184212832 0.461864059021574 no 1495 0.474273585289386 2261 275685 SGTC_942 3253-1115 227 µM 0.0641011545150153 0.462023652162578 no 1496 0.474444841284314 2260 46497897 SGTC_949 1165-0505 146 µM 0.0639919969728739 0.462064151176117 no 1497 0.47448829961935 2227 6244267 SGTC_3248 9135562 49.47 µM 0.0639900207116691 0.462064884400991 no 1498 0.474489086420935 2285 17650701 SGTC_3163 9099914 49.47 µM 0.0633926718675763 0.462286516381978 no 1499 0.474726911259286 2298 16268368 SGTC_2407 paclitaxel 400 µM 0.0632941083709503 0.462323087133948 no 1500 0.474766153598666 2187 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_727 3032-0951 202 µM 0.0631608763132735 0.462372521727839 no 1501 0.474819199362554 2232 3652836 SGTC_81 0411-0046 9.971 µM 0.0621371948740285 0.462752369137031 no 1502 0.47522678849357 2293 12925265 SGTC_785 1270-0111 65.3 µM 0.0613399775924343 0.463048208262063 no 1503 0.47554422660664 2319 6741994 SGTC_631 k072-0230 41.5 µM 0.0603123059725027 0.463429596750838 no 1504 0.475953450520265 2255 5773147 SGTC_167 3672-0051 66.205 µM 0.0602161999890911 0.463465265233763 no 1505 0.475991721701037 2297 3237971 SGTC_597 k018-0003 82.8 µM 0.0602102037468453 0.463467490670644 no 1506 0.475994109522988 2274 6786234 SGTC_2330 7979373 200 µM 0.0601775976347221 0.463479592077066 no 1507 0.476007093935145 2251 1863007 SGTC_2425 5628681 7.85 µM 0.0592828277566959 0.463811689404377 no 1508 0.476363419260951 2257 5714958 SGTC_1657 st012939 43.4 µM 0.0589906916328888 0.463920122337139 no 1509 0.476479761101192 2286 24207257 SGTC_828 2074-0507 139 µM 0.0581358923955177 0.464237415780932 no 1510 0.476820192365454 2291 X828 SGTC_1605 st000082 49.1 µM 0.0574474210589075 0.464492986417815 no 1511 0.477094394402176 2272 1114022 SGTC_1317 1273-0028 910 nM 0.0551286240944505 0.465353864944617 no 1512 0.478017996042133 2282 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1578 josamycin 24.2 µM 0.0548707133856277 0.465449627188755 no 1513 0.478120732024296 2152 5282165 A P450 substrate. SGTC_355 1311-2252 105 µM 0.0543854627274525 0.465629806173487 no 1514 0.478314030388059 2224 5338538 SGTC_2850 9015429 58.44 µM 0.0534301536025663 0.46598454366793 no 1515 0.478694590209177 2269 6457570 SGTC_2721 ifenprodil 61.44 µM 0.0529179880506976 0.46617473862061 no 1516 0.478898626042356 2287 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2426 5582046 32.21 µM 0.0523868257578438 0.466371996257434 no 1517 0.4791102356128 2299 2251934 SGTC_1208 2323-2347 50.3 µM 0.0516306596543962 0.466652827754825 no 1518 0.479411494520645 2312 5412760 SGTC_2208 7283366 200 µM 0.050736089037014 0.466985082544188 no 1519 0.479767909388208 2307 898663 SGTC_456 gingerol 170 µM 0.0499048147630101 0.467293848901913 no 1520 0.480099120230211 2276 442793 A herb. SGTC_2271 7849410 118.62 µM 0.0496336040678532 0.467394590965265 no 1521 0.48020718372492 2337 972430 SGTC_481 bay k-8644 50 µM 0.0494983705023424 0.467444824678061 no 1522 0.480261067880271 2269 2303 A calcium channel antagonist. SGTC_1062 mesoridazine 14.2 µM 0.0493111365941661 0.467514375237128 no 1523 0.480335672298538 2320 4078 A neuroleptic. SGTC_2005 4024620 188 µM 0.0492992354540885 0.46751879610958 no 1524 0.480340414398969 2314 236743 SGTC_247 mechlorethamine 29.705 µM 0.0486860107280669 0.467746593837947 no 1525 0.480584762238437 2298 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1842 st055362 61.2 µM 0.0479700734960745 0.468012560066044 no 1526 0.480870046514774 2246 676032 SGTC_189 3970-0742 2.116 µM 0.0475479158387968 0.468169395709489 no 1527 0.481038271089037 2329 2891807 SGTC_822 1487-0950 154 µM 0.0474852038862279 0.468192694227092 no 1528 0.481063261310714 2338 1958375 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0470914912007091 0.468338967424605 no 1529 0.481220154426943 2332 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1866 st057638 64 µM 0.0469615835067478 0.468387232019834 no 1530 0.481271922824137 2279 688802 SGTC_1391 3442-0225 151 µM 0.0437183242619616 0.469592348647243 no 1531 0.482564466266103 2309 5227075 SGTC_2751 anetholtrithion 17.25 µM 0.0435425818174228 0.469657658342315 no 1532 0.482634510657036 2306 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2948 9070189 9.45 µM 0.0430798124681899 0.469829637346217 no 1533 0.482818955837071 2326 6473636 YDL196W YDL196W SGTC_3315 9136395 68.55 µM 0.0430322328919744 0.469847319666909 no 1534 0.4828379197557 2325 16876844 SGTC_202 3594-0513 34.79 µM 0.0425073446516768 0.470042391383109 no 1535 0.483047128429319 2323 708429 SGTC_868 0527-0199 213 µM 0.0400401002688086 0.470959424222388 no 1536 0.484030578260347 2210 2849450 SGTC_893 0958-0369 48.9 µM 0.0390532622876492 0.471326258534297 no 1537 0.484423961904475 2344 6819948 SGTC_596 1155-0152 116 µM 0.0389220661831682 0.471375029506261 no 1538 0.484476261813507 2333 280313 SGTC_1610 st001799 48.1 µM 0.0386216400238686 0.471486711845013 no 1539 0.484596024459308 2317 621897 SGTC_62 0180-0423 3.232 µM 0.0371837547683683 0.472021271386104 no 1540 0.485169245735841 2295 30102 YGL099W LSG1 SGTC_3117 9124945 49.47 µM 0.0367644667363807 0.472177158739956 no 1541 0.485336403159992 2324 17592065 SGTC_505 gw-5074 63.9 µM 0.036497345654167 0.472276474074589 no 1542 0.485442897581037 2315 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1630 st005209 31.3 µM 0.0359229941765985 0.472490023173563 no 1543 0.485671880498386 2345 3367314 SGTC_2233 sulbentine 40.3845 µM 0.0358296990961868 0.47252471188051 no 1544 0.485709075905467 2319 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3340 9146634 11.102 µM 0.0356860922134959 0.472578107783426 no 1545 0.485766330147564 2285 4907387 SGTC_452 diindolylmethane 8 µM 0.0340534348071122 0.473185196783383 no 1546 0.48641727028462 2335 3071 Inhibits expression of several cancer promoting factors. SGTC_2692 st077426 47.7 µM 0.0333039354892428 0.473463912322281 no 1547 0.48671610771784 2338 25238571 SGTC_1403 3909-7815 62.9 µM 0.0329863463144651 0.473582017807924 no 1548 0.48684273788984 2320 6615483 SGTC_2296 7971656 126.45 µM 0.0325930225502561 0.473728290791373 no 1549 0.486999567037114 2311 666570 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0317937932593351 0.474025526674438 no 1550 0.487318248198674 2318 5379071 SGTC_2737 bleomycin 30.5 nM 0.0317339080430514 0.474047798758817 no 1551 0.487342126894266 2342 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2061 5245884 80.95 µM 0.029799264910075 0.474767360743815 no 1552 0.488113572512237 2356 573863 SGTC_1210 3013-0140 750 nM 0.0288797313244479 0.475109396705682 no 1553 0.488480255469439 2361 905973 SGTC_2676 harmalol 100 µM 0.0288681628185552 0.475113699923131 no 1554 0.488484868712118 2350 5459187 A monoamine oxidase inhibitor SGTC_3269 9137823 49.47 µM 0.0287520234499973 0.47515690125111 no 1555 0.488531182391966 2337 17682936 SGTC_99 0109-0120 622.8 µM 0.0281846169745019 0.475367968352313 no 1556 0.488757453113584 2353 759414 SGTC_2242 6630449 61.2675 µM 0.0279807547838901 0.47544380386528 no 1557 0.488838750297339 2304 691249 YDR170C SEC7 SGTC_1086 cerivastatin 2.18 µM 0.0271517998967945 0.47575217924877 no 1558 0.489169329813392 2369 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2807 7945238 51.95 µM 0.0256416409885456 0.476314003153799 no 1559 0.489771586136111 2346 17148797 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0256286620033183 0.476318831926951 no 1560 0.489776762301009 2349 688803 SGTC_881 0833-0569 170 µM 0.0241969615504261 0.47685151084063 no 1561 0.490347750876776 2341 5418700 SGTC_2031 5180455 200 µM 0.023825535598463 0.476989710491424 no 1562 0.490495885683221 2363 29949 SGTC_2118 5526350 200 µM 0.0236260930129768 0.477063919953861 no 1563 0.490575429371663 2342 743594 SGTC_2976 9009005 19.48 µM 0.0234361606838526 0.477134591538295 no 1564 0.490651180432939 2365 2993148 SGTC_2053 5265679 138 µM 0.0221276948979021 0.477621475682056 no 1565 0.49117304727394 2370 764595 SGTC_2989 9073649 71.4286 µM 0.0221067184621303 0.477629281352318 no 1566 0.491181413614526 2362 21367202 SGTC_3217 9129673 49.47 µM 0.021306180344285 0.477927180890667 no 1567 0.491500706878728 2360 17248312 SGTC_353 1988-1175 58.3 µM 0.0212555389282144 0.477946026199309 no 1568 0.491520905306536 2328 2788357 SGTC_3003 9075612 71.4286 µM 0.0211547256830801 0.477983542214838 no 1569 0.491561114931129 2339 6501993 SGTC_2434 5670830 169.91 µM 0.0207477702670688 0.478134986058227 no 1570 0.491723431023072 2341 1549830 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0201281850960808 0.47836556370921 no 1571 0.491970558120901 2349 75037 A free radical scavenger. SGTC_1641 st009299 47.1 µM 0.0195469750914265 0.478581866686165 no 1572 0.492202381743073 2372 4046054 SGTC_2376 9072922 81.32 µM 0.019433709888894 0.478624020173459 no 1573 0.492247559439518 2333 17087968 SGTC_736 0958-0254 92.6 µM 0.0192742673151531 0.478683359725596 no 1574 0.492311155911413 2349 6812352 SGTC_2179 6298986 200 µM 0.0180167000813042 0.479151403475475 no 1575 0.492812765417525 2374 738374 SGTC_1015 4130-4525 82 µM 0.0169675477518697 0.479541900997839 no 1576 0.493231252593049 2371 1363237 SGTC_2844 9010103 25.97 µM 0.0161349136999944 0.479851823787264 no 1577 0.493563380015705 2347 2480525 SGTC_2612 dictamnine 15.46 µM 0.0159298407298464 0.479928157861531 no 1578 0.493645181780201 2342 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3228 9131799 49.47 µM 0.015414647299859 0.48011993095689 no 1579 0.493850688979925 2348 17015818 SGTC_1574 spiramycin 23.7 µM 0.0143782155964465 0.480505741145349 no 1580 0.494264119515241 2371 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0142171335877545 0.480565705336728 no 1581 0.494328375371012 2379 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2113 5491891 107.031 µM 0.012477964088943 0.481213154169799 no 1582 0.495022141727005 2376 789979 SGTC_1878 temozolomide 1 mM 0.0123948531820926 0.481244095513421 no 1583 0.495055295617741 2381 5394 DNA alkylating agent. SGTC_2166 5933061 31.504 µM 0.0116343548145311 0.481527226529049 no 1584 0.49535866866658 2376 2877375 SGTC_2890 9046729 58.44 µM 0.0111702231842341 0.481700025780817 no 1585 0.495543818359665 2373 903329 SGTC_1006 4099-6547 255 µM 0.0111347518034571 0.481713232150491 no 1586 0.495557968513189 2371 3146833 SGTC_3101 9120531 49.47 µM 0.0108173982142363 0.48183138713452 no 1587 0.495684566651099 2386 24824904 SGTC_1794 st048918 76.9 µM 0.00910374371566905 0.482469430927809 no 1588 0.496368181888344 2387 672303 SGTC_90 0870-0863 4.608 µM 0.00906448662863649 0.48248404802418 no 1589 0.496383842553985 2383 1738164 SGTC_3242 9133940 49.47 µM 0.00898598584446709 0.482513277301884 no 1590 0.496415158560379 2386 17248444 SGTC_361 000s-0510 1.45 µM 0.00857462162604925 0.482666447737789 no 1591 0.496579262812767 2379 660 SGTC_1631 benzylvanillin 81.9 µM 0.0085075301987986 0.48269142930586 no 1592 0.496606027443487 2377 75506 SGTC_2210 7115885 190.385 µM 0.00819510774292418 0.482807761050631 no 1593 0.496730661623624 2390 2927039 SGTC_1783 st039459 87.517 µM 0.0078635544554978 0.48293121783733 no 1594 0.496862927983893 2385 729761 SGTC_159 3970-0959 50 µM 0.00768669034207787 0.482997075417807 no 1595 0.49693348442384 2380 6615653 SGTC_3127 9126946 49.47 µM 0.00658130396031479 0.483408690400214 no 1596 0.497374458543663 2369 27243249 SGTC_3141 9094609 49.47 µM 0.00631116789904888 0.483509284222092 no 1597 0.497482225000551 2394 25236309 YDL196W YDL196W SGTC_1814 st052110 31.539 µM 0.00557214700304409 0.483784487687734 no 1598 0.497777046471228 2395 674163 SGTC_1001 4048-4355 44.4 µM 0.0052233122848027 0.483914392692108 no 1599 0.497916209361197 2386 21824233 SGTC_657 3534-0529 86.7 µM 0.00499865811920099 0.483998054135333 no 1600 0.498005832235555 2392 1049549 SGTC_2785 7756463 72.73 µM 0.00420658606574236 0.484293028181745 no 1601 0.498321819911565 2393 2201551 SGTC_1181 1222-0449 220 µM 0.00328095752968854 0.484637750624718 no 1602 0.49869108966954 2399 658318 SGTC_1782 st039423 80.636 µM 0.00292239052563461 0.484771291195076 no 1603 0.498834136518964 2398 2068169 SGTC_2043 5101342 149 µM 0.00282345590595306 0.484808137568066 no 1604 0.498873605558851 2396 678451 SGTC_688 0527-0193 473 µM 0.00251827185605871 0.484921798550294 no 1605 0.498995355944931 2404 4007154 SGTC_154 3389-1638 511.116 µM 0.00179463628408115 0.485191310076443 no 1606 0.499284044092653 2394 5238686 SGTC_1912 st060209 90.8 µM 0.000650608726586282 0.485617406549599 no 1607 0.499740444689278 2402 688787 SGTC_1253 0550-0034 176 µM 0.000505994110473117 0.485671269873564 no 1608 0.499798137564312 2403 5969915 SGTC_67 0335-0847 266 µM 0.000226487900298606 0.485775375813733 no 1609 0.499909644401344 2403 4552207 YOR254C SEC63 SGTC_1134 3477-0009 42.5 µM 0 0.485859735065098 no 1610 0.5 2406 3973534 SGTC_757 1066-0008 322 µM -0.000209346610432248 0.485937710315831 no 1611 0.49991648278645 2406 6842497 SGTC_2306 7482397 179.52 µM -0.00136517399159361 0.486368230490074 no 1612 0.499455374543819 2408 891448 SGTC_1111 tnp00062 510.699 nM -0.00299202998892821 0.486974225225966 no 1613 0.498806354514155 2413 676306 SGTC_2037 5169046 200 µM -0.0030083365558074 0.486980299485273 no 1614 0.498799849164457 2417 5718022 SGTC_399 oxolinic acid 75 µM -0.00333265443122877 0.487101109775332 no 1615 0.498670465702514 2420 4628 A DNA gyrase inhibitor. SGTC_879 0831-1030 162 µM -0.00345964019521229 0.487148413032187 no 1616 0.498619806004436 2417 1549252 SGTC_401 neomycin 50 µM -0.00384601478719028 0.487292341901457 no 1617 0.498465665872943 2416 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3184 9108758 49.47 µM -0.00411264552998448 0.487391665810137 no 1618 0.49835929643889 2411 902885 SGTC_2801 7907800 81.82 µM -0.00434218738715561 0.487477174185169 no 1619 0.498267723305401 2417 6620925 SGTC_3001 9076041 71.4286 µM -0.00492638034970356 0.487694798916343 no 1620 0.498034666538687 2417 16004211 SGTC_2904 7225135 42.03 µM -0.00527565787409934 0.487824914232894 no 1621 0.49789532678017 2410 4446116 SGTC_633 0437-0093 97.7 µM -0.00665521360496433 0.488338848557961 no 1622 0.497344973507239 2415 2831118 SGTC_609 0986-0026 86.3 µM -0.00673297881793733 0.488367819492403 no 1623 0.497313950370943 2413 2848610 SGTC_1357 1503-1303 39.5 µM -0.00735483688852786 0.488599490948095 no 1624 0.497065871052679 2423 292895 SGTC_194 1486-1323 56.904 µM -0.00788097984669228 0.488795507018172 no 1625 0.496855976473998 2424 5178754 SGTC_450 aminopyrene 156 nM -0.00792777483651495 0.488812940757772 no 1626 0.496837308557236 2418 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_673 1082-0474 110 µM -0.00920672019593905 0.48928942728752 no 1627 0.496327101938157 2422 3098046 SGTC_2842 9000675 19.48 µM -0.00940426547951013 0.489363026547198 no 1628 0.49624829618443 2428 2989072 SGTC_1953 st076800 12.1 µM -0.0104537815990309 0.489754049789859 no 1629 0.495829620487792 2435 297591 SGTC_1482 3346-2049 8.48 µM -0.0106238708727386 0.489817421701649 no 1630 0.49576176845331 2452 3826804 SGTC_3223 9129970 49.47 µM -0.0115195504521876 0.49015113846701 no 1631 0.495404465911558 2431 17248386 SGTC_337 1315-0038 354 µM -0.0122222358085704 0.490412953320068 no 1632 0.495124154769998 2434 1626437 SGTC_2977 9011197 71.43 µM -0.0126314641580388 0.490565430387833 no 1633 0.494960908885435 2447 2704722 SGTC_68 0986-0284 82.829 µM -0.0127984367414564 0.490627644192266 no 1634 0.494894301846716 2509 423278 YIL048W NEO1 SGTC_66 0109-0187 42.4 µM -0.0139517799231386 0.491057384763055 no 1635 0.494434225667392 2428 759417 SGTC_1556 plumbagin 1.48 µM -0.0141964730758369 0.491148559823217 no 1636 0.494336616891002 2432 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1901 st060216 58.6 µM -0.0148631231231278 0.491396962478713 no 1637 0.494070690077885 2426 688792 SGTC_1055 3448-0672 86 µM -0.0163073546685173 0.491935113635661 no 1638 0.493494595072694 2471 748378 SGTC_378 3970-0959 8.33 µM -0.0183299752859019 0.492688809224371 no 1639 0.492687807330191 2460 6615653 SGTC_2704 st078022 71.1 µM -0.0192001701894994 0.493013080921909 no 1640 0.49234071091846 2440 54697681 SGTC_1886 st057356 49.9 µM -0.0195619325841206 0.493147890374796 no 1641 0.492196415707574 2447 24207747 SGTC_644 1498-1197 63.3 µM -0.0207470384189 0.493589521193352 no 1642 0.491723722925417 2464 6741615 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0213218928046575 0.493803744091424 no 1643 0.491494439937616 2464 115019 SGTC_3029 9088683 49.47 µM -0.0219009642754482 0.494019540317775 no 1644 0.491263477789947 2475 25236615 SGTC_1133 3473-0247 50 µM -0.0220890467302342 0.494089631326994 no 1645 0.491188461894442 2489 711311 SGTC_2714 st079313 56.9 µM -0.022283586395151 0.494162128879007 no 1646 0.491110870895775 2451 2939799 SGTC_886 0866-0150 153 µM -0.0223805085920631 0.494198248176547 no 1647 0.491072214174181 2449 271463 SGTC_2947 9072639 7.68 µM -0.0234805921320873 0.494608211653808 no 1648 0.490633459726143 2456 16488146 SGTC_51 1013-0126 23.419 µM -0.0245198802793006 0.494995524007864 no 1649 0.490218963155903 2438 1627850 SGTC_3298 9116858 71.43 µM -0.0245687289029297 0.495013728582855 no 1650 0.490199481243659 2478 2506942 SGTC_2696 st077691 74.316 µM -0.0257446514003093 0.495451966479384 no 1651 0.489730504489566 2492 757133 SGTC_963 1269-2853 151 µM -0.0271454128028755 0.495974003521415 no 1652 0.489171876956351 2465 3668223 SGTC_335 4077-0256 27.6 µM -0.0289729865798491 0.496655115618829 no 1653 0.488443067566654 2528 3121989 SGTC_1817 st052116 64.4 µM -0.0296074805301604 0.496891585337652 no 1654 0.488190049665018 2469 4361398 SGTC_1166 k206-0078 225 µM -0.0298485381755865 0.496981425466328 no 1655 0.488093924063581 2466 5404595 SGTC_1689 st020265 53.493 µM -0.0298763778529319 0.496991801086601 no 1656 0.48808282259028 2464 5758320 YPR016C TIF6 SGTC_2199 6590217 200 µM -0.0300152325021145 0.497043551110039 no 1657 0.488027452432131 2471 703109 SGTC_1980 st071811 45.7 µM -0.0303019956059346 0.497150425594687 no 1658 0.487913102520799 2565 4974850 SGTC_1948 st076329 66.6 µM -0.0307315786061208 0.497310528377079 no 1659 0.487741803482169 2452 24208413 SGTC_682 0kpi-0099 17 µM -0.0308175303080914 0.49734256206865 no 1660 0.487707529947807 2501 1714895 YML126C ERG13 SGTC_777 1315-0167 517 µM -0.031195632863591 0.497483478858165 no 1661 0.487556761345488 2506 4221767 SGTC_1966 st070145 16.1 µM -0.0312530503245296 0.497504878065041 no 1662 0.487533866256303 2459 3748532 SGTC_3210 9128157 49.47 µM -0.0324245494262015 0.497941491531292 no 1663 0.487066742583682 2548 17590849 SGTC_2626 ethyl orsellinate 100 µM -0.0324979886013786 0.497968862133094 no 1664 0.487037460023752 2482 75653 A natural product. SGTC_1910 st062352 60.4 µM -0.0329835986572453 0.498149848053267 no 1665 0.486843833450326 2458 2245730 SGTC_1042 0350-0096 82 µM -0.0330320239367638 0.498167896081936 no 1666 0.486824525080138 2459 3122515 SGTC_1102 cgs 12066b 26.1 µM -0.0336724024314158 0.498406564519941 no 1667 0.486569193078867 2515 6438352 A 5-HT1B full agonist. SGTC_2515 chrysin 20.77 µM -0.0340056576646828 0.498530768650134 no 1668 0.486436319573942 2490 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_771 0250-0039 27.3 µM -0.0351497461569077 0.498957171113592 no 1669 0.485980167100194 2464 3005115 SGTC_645 0845-0943 5.41 µM -0.0352729265708496 0.49900308060702 no 1670 0.485931055679533 2489 1885106 SGTC_3083 9117465 49.47 µM -0.035438922941878 0.499064947681659 no 1671 0.485864874086608 2532 16420915 SGTC_882 0843-0131 351 µM -0.0356905528673351 0.49915873054161 no 1672 0.485764551737052 2453 5425421 SGTC_2769 toremifene 3.73 µM -0.0366676340080444 0.499522890577973 no 1673 0.485375007799819 2523 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2921 7974240 10.71 µM -0.0378026693587238 0.499945920933378 no 1674 0.484922508027338 2495 2979074 YDR527W RBA50 SGTC_2847 9005661 71.43 µM -0.0380928690348116 0.499945920933378 no 1675 0.484806818435615 2475 2991449 SGTC_1433 4060-0023 7.6 µM -0.0382522957019852 0.499886502223476 no 1676 0.484743262719376 2519 3840627 SGTC_2959 9079155 11 µM -0.0391809209093575 0.499540401423104 no 1677 0.484373072431933 2545 16189457 SGTC_105 0111-0055 734.78 µM -0.0396143086115245 0.499378876909039 no 1678 0.484200309885723 2550 5179370 SGTC_1647 st011722 22.4 µM -0.0401233460390691 0.499189157714176 no 1679 0.483997394669102 2505 2854783 SGTC_1479 0549-0158 134 µM -0.0401825085631699 0.499167107742615 no 1680 0.483973811255759 2483 5440202 SGTC_3329 9141233 27.5565 µM -0.0402896047371891 0.499127192826176 no 1681 0.483931120634667 2519 4909101 YNL103W MET4 SGTC_421 streptovitacin 30 mM -0.0415285301233323 0.498665444078082 no 1682 0.483437274359033 2642 91467 include heat shock SGTC_1874 staurosporine 7.6 µM -0.0416292680595435 0.498627899017343 no 1683 0.483397120461187 2505 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2982 9019404 25.97 µM -0.0418958166916815 0.498528556317203 no 1684 0.483290875634099 2494 22333232 SGTC_2924 9010168 62.78 µM -0.0421450185848741 0.4984356788307 no 1685 0.483191546195291 2524 2993929 SGTC_1436 4092-1007 8.32 µM -0.0422528947721026 0.498395473427299 no 1686 0.483148548124676 2489 2881121 SGTC_2020 4017018 200 µM -0.0426082312588323 0.498263039806053 no 1687 0.483006916927548 2519 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_391 gliotoxin 8.33 µM -0.0430444942350419 0.498100445210904 no 1688 0.482833032715766 2545 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_503 tyrphostin 8 294 µM -0.0430990662800653 0.498080106308439 no 1689 0.48281128180495 2478 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3356 9151811 4.48 µM -0.0433577047454051 0.497983712289025 no 1690 0.482708196348637 2487 1859254 YPR165W RHO1 SGTC_307 1501-1223 22.3 µM -0.0459519020503012 0.497016867784762 no 1691 0.481674292991943 2510 2830329 SGTC_1708 st033234 31.827 µM -0.0466034105174993 0.49677405633155 no 1692 0.481414656892954 2563 674664 SGTC_2146 5545642 200 µM -0.0467908138477169 0.496704212982423 no 1693 0.481339975251709 2483 825326 SGTC_2491 paeonol 100 µM -0.0474054281858055 0.496475153078598 no 1694 0.481095051409731 2484 11092 Increases levels of cortical cytochrome oxidase. SGTC_1726 st035556 14.5795 µM -0.0480784133239169 0.496224340364723 no 1695 0.48082687498938 2709 5919439 SGTC_1622 st003707 19.4 µM -0.0493818510811473 0.495738570580186 no 1696 0.480307495626918 2588 10140899 SGTC_1057 3448-5381 134 µM -0.0494415714722511 0.495716313919911 no 1697 0.480283699704723 2536 5497911 SGTC_703 3875-0075 71.8 µM -0.0501697425030153 0.495444939441851 no 1698 0.479993561581666 2510 2850814 SGTC_2025 5147754 141 µM -0.0505057218409055 0.495319727504468 no 1699 0.479859694928058 2528 315777 YLR208W SEC13 SGTC_50 0929-0078 56.389 µM -0.0509583620075553 0.495151039433168 no 1700 0.479679349859369 2595 1377751 SGTC_1139 k015-0024 46.9 µM -0.0511478002648495 0.495080440620033 no 1701 0.479603873354868 2485 2766652 SGTC_111 0083-0039 52.457 µM -0.0539739327735674 0.49402723253437 no 1702 0.478477966296516 2483 759313 SGTC_1937 st074714 47.2 µM -0.0551933609542514 0.493572803560058 no 1703 0.477992209033039 2501 17250970 SGTC_290 2043-6722 48.1 µM -0.0562280592114289 0.493187222082395 no 1704 0.477580064249097 2544 773758 YLR208W SEC13 SGTC_1476 4112-3294 3.34 µM -0.0570370422953195 0.492885758035364 no 1705 0.477257843836144 2605 704369 SGTC_2569 tetrandrine 100 µM -0.0574592944572422 0.492728409196616 no 1706 0.477089665412946 2550 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2884 9058502 51.95 µM -0.0576848154683578 0.492644371085391 no 1707 0.476999844527626 2547 6471554 SGTC_1930 st074634 34.3 µM -0.0581118208846867 0.492485252757003 no 1708 0.476829779301023 2512 684253 YOR116C RPO31 SGTC_2449 5812982 45.77 µM -0.0598650782861336 0.491831935710256 no 1709 0.476131546739802 2486 776185 SGTC_1028 k015-0029 4.8 µM -0.062764925832147 0.490751413220919 no 1710 0.474976847954212 2527 4588309 SGTC_3027 9089541 49.47 µM -0.0630623576757483 0.490640589789071 no 1711 0.474858424416426 2589 9943819 SGTC_2476 5806916 10.51 µM -0.0634514012045588 0.490495632834545 no 1712 0.474703528717427 2551 2870194 SGTC_2325 6158266 200 µM -0.0634902591523138 0.490481154498199 no 1713 0.474688057833131 2574 3623240 SGTC_2349 9023730 187.07 µM -0.0640158685485184 0.49028531550308 no 1714 0.474478795724844 2555 4126287 SGTC_43 0570-0105 72.5 µM -0.0658468968372479 0.489603103637929 no 1715 0.473749859474647 2531 1114046 YDL195W SEC31 SGTC_1974 st069448 26.9 µM -0.0658936832432897 0.48958567216111 no 1716 0.473731234848141 2537 6323587 YNR016C ACC1 SGTC_187 1488-2104 32.728 µM -0.0666743686662124 0.489294810723445 no 1717 0.473420469867697 2586 2852859 SGTC_1385 3091-4834 14.1 µM -0.0679749164750733 0.488810275896085 no 1718 0.472902800920947 2587 4072814 SGTC_2879 9041815 71.43 µM -0.0680547245503662 0.488780542962192 no 1719 0.472871035663732 2518 4942971 SGTC_284 0988-0104 32.6 µM -0.0683502249538148 0.488670453218744 no 1720 0.472753421922418 2589 4666532 SGTC_742 0kpi-0133 140 µM -0.0690928360405366 0.488393794603184 no 1721 0.472457861706996 2603 2728852 SGTC_2310 7668677 200 µM -0.069227462976917 0.488343640139673 no 1722 0.472404281623536 2586 2197143 SGTC_1132 3456-3614 2.5 µM -0.0694784981794762 0.488250118962691 no 1723 0.472304373627309 2640 3125502 SGTC_2689 tacrolimus 100 µM -0.0694983632997955 0.488242718396929 no 1724 0.472296467701411 2611 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3284 9108171 64.8615 µM -0.0697598548454736 0.48814530253268 no 1725 0.47219240024477 2587 8687505 SGTC_230 MPP+ 141.667 µM -0.0709879265651231 0.487687807171928 no 1726 0.471703682226866 2570 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2246 7293507 91.5585 µM -0.0711705375453945 0.487619780204417 no 1727 0.471631014785427 2660 887656 SGTC_363 0455-0021 3.06 µM -0.0719267283072665 0.487338084875192 no 1728 0.471330109510337 2544 4597466 SGTC_3215 9129942 49.47 µM -0.0722406936997807 0.48722112868936 no 1729 0.471205180432757 2559 17682944 SGTC_2743 auranofin 4.32 µM -0.0727818387594624 0.487019547712678 no 1730 0.470989861596665 2561 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_806 3966-4455 5.86 µM -0.0733235550711533 0.486817757261616 no 1731 0.470774323956072 2558 714982 SGTC_1744 st037937 38.9 µM -0.0735775240177146 0.486723154460526 no 1732 0.470673277944304 2619 1016152 SGTC_1829 berberine 14.4 µM -0.0737684244763091 0.48665204500596 no 1733 0.470597326082316 2687 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2984 9022109 38.96 µM -0.074002303742641 0.486564926741755 no 1734 0.470504276083778 2510 6459207 SGTC_725 1497-0963 19 µM -0.0741155086750313 0.486522758987568 no 1735 0.470459237531394 2567 3549977 SGTC_3052 9092717 49.47 µM -0.0750176952710634 0.486186708537322 no 1736 0.470100316386632 2635 25237534 SGTC_184 1494-0393 24.714 µM -0.0758429908981215 0.485879307359615 no 1737 0.46977200640494 2530 3090647 SGTC_1521 st012942 49.4 µM -0.0767955047222288 0.485524531151137 no 1738 0.469393113445674 2763 24207259 SGTC_511 blebbistatin 171 µM -0.0769097296514483 0.485481987348932 no 1739 0.469347678666555 2678 3476986 A myosin inhibitor. SGTC_2726 cimetidine 79.27 µM -0.0772176283409658 0.485367309345935 no 1740 0.469225209064062 2550 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1473 k844-0725 134 µM -0.0791758519427209 0.484637990459869 no 1741 0.468446375820242 2552 54682906 SGTC_3082 9117008 49.47 µM -0.0799151581633546 0.484362657204296 no 1742 0.468152366958981 2592 41448529 SGTC_1837 st055472 66.5 µM -0.0801060039682658 0.484291583400104 no 1743 0.468076473809997 2682 676091 SGTC_1335 1486-0900 202 µM -0.0805559906044492 0.484124003692213 no 1744 0.467897533406543 2550 X1335 SGTC_2849 9019321 12.99 µM -0.0806811428035953 0.484077396207514 no 1745 0.467847766890996 2636 16489627 SGTC_1005 4092-0690 4.4 µM -0.0808158121852853 0.48402724470578 no 1746 0.467794216448618 2583 1529343 SGTC_231 b-estradiol 524 µM -0.0813106563833986 0.483842964609778 no 1747 0.467597449742433 2544 450 A steroid. SGTC_308 4092-1169 104 µM -0.0820162766472864 0.483580197436099 no 1748 0.46731688508442 2560 2268590 YDL196W YDL196W SGTC_787 4152-0075 138 µM -0.0830737503384323 0.483186416331864 no 1749 0.466896448939333 2590 9566539 SGTC_23 0213-0011 39.996 µM -0.0831652901629918 0.48315232957992 no 1750 0.466860055767945 2612 627608 SGTC_2560 caryophyllene 100 µM -0.0838303130085368 0.482904698245249 no 1751 0.466595673272403 2548 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_913 3487-1245 167 µM -0.083922122761766 0.482870512008196 no 1752 0.466559175092532 2551 4016153 SGTC_1721 st082152 9.2685 µM -0.0841920669342614 0.482769996452019 no 1753 0.466451862732402 2558 5296051 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0852838037850483 0.482363492016566 no 1754 0.466017883662556 2788 6710655 SGTC_375 3970-0961 9.27 µM -0.0858678543436824 0.482146030314788 no 1755 0.465785732808464 2608 2898222 SGTC_1223 0764-0573 147 µM -0.0859867730689941 0.482101753515333 no 1756 0.465738465921139 2573 1609797 SGTC_550 4123-0385 25.7 µM -0.0864050865158477 0.481946005364503 no 1757 0.465572201800057 2574 5731123 SGTC_527 4476-4215 268 µM -0.0865055026905514 0.481908618418272 no 1758 0.465532290978491 2581 4418754 SGTC_1199 1638-0010 4.46 µM -0.0867713962467737 0.481809621709139 no 1759 0.465426612166612 2552 3111136 SGTC_1445 4239-0156 97.7 µM -0.0875309829279028 0.481526820823274 no 1760 0.465124729559769 2733 4008346 SGTC_1503 4585-0012 61.3 µM -0.0876346970013128 0.481488207868229 no 1761 0.465083512019182 2740 2922052 SGTC_2374 9071832 200 µM -0.0884797383060709 0.481173603820162 no 1762 0.464747693830629 2555 17381698 SGTC_2840 9008771 71.43 µM -0.0885387184795495 0.48115164627413 no 1763 0.464724256129866 2691 2992978 SGTC_1234 0326-0494 15.5 µM -0.0885543392334655 0.481145830881632 no 1764 0.464718048732948 2663 1547813 SGTC_1353 1498-1206 8.11 µM -0.0888310472195893 0.481042816958671 no 1765 0.464608091553185 2553 6756808 SGTC_2490 carminic acid 95.39 µM -0.0894564046660653 0.480810011135386 no 1766 0.464359599330176 2544 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_918 glabranin 770.725 nM -0.0918500604195115 0.479918970732225 no 1767 0.463408584833573 2617 124049 Also referred to as licorice root. SGTC_1337 1486-1011 40.3 µM -0.0918827949883761 0.479906785946258 no 1768 0.463395580620106 2568 X1337 SGTC_3076 9116187 49.47 µM -0.091956347125275 0.479879407708692 no 1769 0.463366361264202 2638 27241210 SGTC_1294 1000-1494 117 µM -0.0923196651224388 0.479744171612831 no 1770 0.463222032290832 2573 712797 YDL207W GLE1 SGTC_1371 2421-0008 32.7 µM -0.0924088639278246 0.479710969930039 no 1771 0.463186598584098 2633 2827552 SGTC_956 1185-0240 191 µM -0.092581132647371 0.479646848266117 no 1772 0.463118166664003 2616 1416193 SGTC_2345 9052315 157.45 µM -0.093609340161838 0.479264141062862 no 1773 0.4627097449107 2642 6469265 SGTC_529 4076-0302 30.3 µM -0.0949896178134966 0.478750420607895 no 1774 0.46216153670784 2578 5816522 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.094992715230143 0.47874926783118 no 1775 0.462160306579839 2567 15053 SGTC_890 0929-0006 47.2 µM -0.095207212246511 0.478669438136642 no 1776 0.462075120733955 2576 1378169 SGTC_2956 9076196 2.52 µM -0.0954343674194778 0.478584898368934 no 1777 0.461984909694928 2607 16423868 SGTC_2800 7887935 81.82 µM -0.0964495514320071 0.478207091724539 no 1778 0.4615817695875 2671 2961002 SGTC_3017 9080681 49.47 µM -0.0966317999680284 0.478139268933675 no 1779 0.461509400969496 2644 16451914 SGTC_1059 3448-6867 171 µM -0.0967080050592556 0.478110909815463 no 1780 0.461479141257036 2546 3934407 SGTC_3150 9097574 49.47 µM -0.0984523202822877 0.477461807376479 no 1781 0.460786565428028 2608 17217476 SGTC_2049 5262831 67.185 µM -0.0986693171257996 0.47738106167991 no 1782 0.460700415669954 2603 763417 SGTC_3206 9114350 49.47 µM -0.0990930394529469 0.477223394995127 no 1783 0.460532199299928 2603 17087243 SGTC_1711 st032263 62.8 µM -0.0992973534087485 0.477147371234239 no 1784 0.460451089853638 2625 3958979 SGTC_2294 7971431 200 µM -0.100009279871789 0.476882475007729 no 1785 0.460168479055933 2671 5741572 SGTC_1736 st036774 51 µM -0.100446764370382 0.476719699220222 no 1786 0.459994822435421 2820 1272247 SGTC_1363 1636-0063 10.4 µM -0.100469898735165 0.47671109167583 no 1787 0.459985639612238 2593 6072185 SGTC_448 monastrol 171 µM -0.100477837432493 0.476708137947366 no 1788 0.45998248847579 2611 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2717 st081029 62.2815 µM -0.10104533336388 0.476496994680726 no 1789 0.459757236743961 2583 5292846 SGTC_2719 novobiocin 32.65 µM -0.101279715066754 0.476409792244737 no 1790 0.459664209208308 2620 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_539 4859-0462 2.54 µM -0.101685102440383 0.476258969290328 no 1791 0.459503313688595 2722 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1451 4152-0210 104 µM -0.101733084829613 0.476241117834937 no 1792 0.459484270239758 2574 659563 SGTC_2412 st077135 33.4 µM -0.101909928483134 0.476175325012337 no 1793 0.459414084603058 2875 13258915 SGTC_520 3584-0023 682 µM -0.1019968477622 0.476142987846079 no 1794 0.459379588578716 2684 1340790 SGTC_1106 tegaserod maleate 11.7 µM -0.102245387204168 0.476050522907079 no 1795 0.4592809513606 2635 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1379 2144-0755 36.5 µM -0.102504934521955 0.475953964048807 no 1796 0.459177948150335 2632 5392327 SGTC_487 nimodipine 119 µM -0.102505252632717 0.475953845703576 no 1797 0.459177821907482 2562 4497 L-type voltage-gated calcium channels inhibitor SGTC_2833 9001315 45.46 µM -0.102566106319225 0.47593120663548 no 1798 0.459153672083659 2652 2989378 SGTC_1845 st056753 3.01 µM -0.102626801621368 0.475908626567657 no 1799 0.459129585264913 2544 5375839 SGTC_1252 0493-0875 34.8 µM -0.103118533867863 0.475725693563394 no 1800 0.458934447768899 2589 3960963 SGTC_811 0416-0114 265 µM -0.104342480915439 0.475270386134307 no 1801 0.458448783492294 2675 6612453 SGTC_2541 muurolladie-3-one 83.07 µM -0.104400597627637 0.475248767557176 no 1802 0.458425724218427 2759 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1651 st011928 86.1 µM -0.105021181551869 0.475017923861302 no 1803 0.4581795006067 2685 720198 SGTC_3033 9090887 49.47 µM -0.108633566714815 0.473674364252423 no 1804 0.456746567955215 2610 19325384 SGTC_1748 st037455 53.6035 µM -0.108709952375081 0.4736459572026 no 1805 0.456716273894521 2713 580690 SGTC_2128 5255449 168.493 µM -0.11054437693166 0.472963793961046 no 1806 0.455988828898884 2622 736008 SGTC_3349 9149703 23.001 µM -0.111799865646646 0.472496963838372 no 1807 0.455491047027526 2577 4910494 SGTC_3330 9141424 71.43 µM -0.113044241628362 0.472034303053356 no 1808 0.454997740121514 2723 27261020 SGTC_1939 st074455 53.6 µM -0.113689303610561 0.471794482888389 no 1809 0.454742046011898 2756 1644229 SGTC_2154 5570129 200 µM -0.114176240477613 0.471613457007441 no 1810 0.454549043038111 2590 673366 SGTC_1406 3909-7906 11.9 µM -0.114771462273994 0.471392182594403 no 1811 0.454313134678233 2643 X1406 SGTC_1727 st034309 9.9045 µM -0.11629368935359 0.470826333192286 no 1812 0.453709893422614 2925 870305 SGTC_2835 9006588 71.43 µM -0.117928740992844 0.470218609750618 no 1813 0.45306206006115 2843 2345538 SGTC_995 3931-2021 34.6 µM -0.118220707898688 0.470110097418834 no 1814 0.452946391241741 2704 730143 SGTC_1108 betulinic acid 729.144 nM -0.118497336030568 0.470007287938788 no 1815 0.452836802882818 2628 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2303 7774051 200 µM -0.119102487830627 0.469782388863953 no 1816 0.452597079885731 2721 2953184 SGTC_2810 7959871 45.46 µM -0.119159410805775 0.469761234461119 no 1817 0.452574531478833 2718 2974535 SGTC_1765 st044815 90.4 µM -0.120492927643518 0.469265681391992 no 1818 0.452046340876084 2693 645695 SGTC_716 1683-5115 658 µM -0.123388036023405 0.468189984476257 no 1819 0.450899915274494 2614 723597 SGTC_360 0957-0399 1.01 µM -0.123928342891471 0.467989255316606 no 1820 0.450686005773451 2741 6752301 YPR165W RHO1 SGTC_594 1487-1584 10.8 µM -0.124377651624809 0.467822339028508 no 1821 0.450508133677721 2660 5013332 SGTC_1989 st071868 50.2 µM -0.124437257380044 0.467800196167728 no 1822 0.450484537729941 2716 16414057 SGTC_162 k030-0015 37.8 µM -0.124505421786125 0.467774873987529 no 1823 0.45045755390978 2691 1809920 YMR134W ERG29 SGTC_855 0428-0020 25 µM -0.124509850296201 0.4677732288588 no 1824 0.450455800830917 2646 6812414 SGTC_712 r015-0009 80.6 µM -0.126518395292406 0.467027140030945 no 1825 0.44966079435512 2733 6813872 YLR060W FRS1 SGTC_1710 st031758 61.5 µM -0.127599906700074 0.46662545246652 no 1826 0.449232802485895 2786 5394341 SGTC_2670 beta-carotene 100 µM -0.130412407793826 0.465581012712161 no 1827 0.448120075212588 2647 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1404 3909-7820 48.3 µM -0.130689628717303 0.465478077716777 no 1828 0.448010418529153 2654 23741373 SGTC_2157 5649910 96.377 µM -0.13071471476095 0.465468763123238 no 1829 0.448000495764281 2651 2858091 SGTC_2765 myclobutanil 7.74 µM -0.131559684578843 0.465155032010847 no 1830 0.447666287660809 2730 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_820 1582-0060 59.9 µM -0.132563728594317 0.464782265986226 no 1831 0.447269209786757 2679 3848840 SGTC_1222 0366-0074 1.18 µM -0.132696352165228 0.464733029849682 no 1832 0.447216763951704 2735 286520 SGTC_1772 st048439 82.2 µM -0.134340991905623 0.464122506966033 no 1833 0.446566470077663 2706 2927068 YDL195W SEC31 SGTC_2967 9089538 49.85 µM -0.136315705514606 0.463389565841729 no 1834 0.445785854285751 2830 728216 SGTC_3207 9114163 49.47 µM -0.137020374257323 0.4631280486513 no 1835 0.445507345336159 2835 849233 SGTC_280 3448-3607 3.04 µM -0.137070364012746 0.463109497019873 no 1836 0.445487588711853 2648 626179 SGTC_2715 st079500 56.4 µM -0.138953918447116 0.462410552467344 no 1837 0.444743281719703 2643 28246688 SGTC_1907 st060210 83.7 µM -0.139212906548884 0.462314456853303 no 1838 0.444640954932542 2804 688793 SGTC_2429 5902844 64.44 µM -0.13933600343177 0.462268783438861 no 1839 0.444592320367627 2797 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.139406645735228 0.462242572803181 no 1840 0.444564410551829 2713 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_560 2332-1943 155 µM -0.14008810485844 0.46198973732116 no 1841 0.444295189431095 2649 21177716 SGTC_583 1488-1091 88.9 µM -0.140155945619793 0.461964567829261 no 1842 0.444268389278273 2646 4303273 SGTC_368 fentichlor 4.58 µM -0.141543084774069 0.461449961100047 no 1843 0.443720462951315 2732 7329 A pesticide. SGTC_1115 galangin 695.678 nM -0.142832604411497 0.460971627537254 no 1844 0.443211193239827 2662 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2445 5742597 35.57 µM -0.142971237217927 0.460920206524686 no 1845 0.443156448584523 2672 1774255 SGTC_1993 st073995 70.8 µM -0.143759138797395 0.460627974302447 no 1846 0.442845335072567 2693 3098394 SGTC_1516 st013856 110 µM -0.143847010363825 0.460595384106311 no 1847 0.442810639985967 2797 5281404 A mutagen and neurotoxin. SGTC_1997 st073024 93.8 µM -0.143935076028447 0.460562722187741 no 1848 0.442775868701908 2651 686268 SGTC_941 3237-0776 460 µM -0.146334869637204 0.459672786482903 no 1849 0.441828520070894 2813 760008 SGTC_468 gf-109203x 121 µM -0.147594832900027 0.459205624270363 no 1850 0.441331266593304 2746 2396 A protein kinase C inhibitor. SGTC_2174 5790901 200 µM -0.149127804258424 0.458637313641767 no 1851 0.440726393286453 2759 786020 SGTC_3036 9090181 49.47 µM -0.149660658663518 0.458439790993742 no 1852 0.440516174177508 2653 25236586 SGTC_480 am 92016 50 µM -0.150845811075722 0.458000506271515 no 1853 0.440048673847097 2729 2129 K+ channel blocker. SGTC_419 nsc-638432 893 µM -0.151652012396859 0.457701711606188 no 1854 0.439730703918838 2739 368090 SGTC_1346 1488-2224 62.4 µM -0.151815111555991 0.457641266630498 no 1855 0.43966638149663 2657 3722427 SGTC_1477 0139-0234 16 µM -0.153425443037511 0.457044526375262 no 1856 0.439031390885811 2659 620880 SGTC_169 k015-0017 16.025 µM -0.155179189334961 0.456394751125921 no 1857 0.438340027022952 2776 1840002 SGTC_2381 9035592 200 µM -0.158080628529602 0.455320004461089 no 1858 0.43719663243293 2724 4749657 SGTC_1434 4073-0095 163 µM -0.15828657723127 0.455243729592121 no 1859 0.437115492311388 2697 24133745 SGTC_3059 1327-0034 3 µM -0.159132441930559 0.454930473676052 no 1860 0.436782264457995 2714 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2893 9048488 25.97 µM -0.159188673930674 0.454909649815904 no 1861 0.436760113485134 2697 6467338 SGTC_2455 5377712 9.75 µM -0.15932119496196 0.454860575056836 no 1862 0.436707911435532 2765 2243908 SGTC_2760 etidronate 98.04 µM -0.161014642852289 0.454233523826205 no 1863 0.436040933896568 2729 3305 A chelator and antioxidant. SGTC_1175 0741-0056 27.6 µM -0.16132166973661 0.454119849835066 no 1864 0.435920028403608 2859 765927 SGTC_1971 st069429 63.5 µM -0.162651403720177 0.453627571078544 no 1865 0.435396455771029 2799 1246522 YGL099W LSG1 SGTC_2730 imipramine 71.33 µM -0.16355545665715 0.453292923678829 no 1866 0.435040556413806 2704 3696 A tricyclic antidepressant. SGTC_1372 2752-0194 270 µM -0.164591046069641 0.452909627045091 no 1867 0.434632939648738 2686 823334 SGTC_2216 7189485 200 µM -0.164640243324732 0.452891419042498 no 1868 0.43461357691761 2789 731273 SGTC_155 k072-0202 43.6 µM -0.164769391113683 0.45284362165867 no 1869 0.434562748529117 2659 5857737 SGTC_2173 5763948 167 µM -0.165044794438105 0.452741697625135 no 1870 0.434454362310481 2685 2867177 SGTC_1737 st035557 69.7 µM -0.165192526402862 0.45268702477576 no 1871 0.434396223760029 2648 5716916 SGTC_3057 9095946 49.47 µM -0.165981378858418 0.452395100378351 no 1872 0.434085802206546 2682 24540043 SGTC_195 4234-0266 16.654 µM -0.166016037601757 0.45238227507993 no 1873 0.434072164565304 2735 2303354 SGTC_1859 st055998 20 µM -0.166261206112287 0.452291553091563 no 1874 0.433975697060319 2703 676301 SGTC_545 4218-0007 221 µM -0.166437250280842 0.452226411363692 no 1875 0.433906430631657 2802 2840508 SGTC_1995 st072814 61.1 µM -0.168248931417121 0.451556108949104 no 1876 0.433193723930753 2711 5769371 SGTC_2516 gossypol 71.55 µM -0.168764547980105 0.451365361561573 no 1877 0.432990922446676 2842 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1142 3253-1408 9.78 µM -0.168860738974404 0.451329777870041 no 1878 0.432953090709769 2685 256655 SGTC_936 3005-4620 401 µM -0.169475864791983 0.451102235189202 no 1879 0.432711177427886 2896 777207 SGTC_1472 k841-0093 193 µM -0.170928696152299 0.450564878742882 no 1880 0.432139916217119 2812 X1472 SGTC_3161 9100388 49.47 µM -0.171074414764328 0.450510987012675 no 1881 0.432082626672073 2726 25236368 SGTC_1463 k081-0032 34.1 µM -0.171466873929241 0.450365846721623 no 1882 0.431928337722989 2762 977755 SGTC_1663 st014140 55.4 µM -0.171990402585101 0.450172244299653 no 1883 0.431722537097868 2717 4207120 SGTC_896 0964-0007 44.5 µM -0.172478963178873 0.449991583863749 no 1884 0.431530499232428 2670 6756758 SGTC_1913 st060213 96.1 µM -0.173277745373119 0.449696231707093 no 1885 0.431216557849791 2838 688959 SGTC_3128 9127691 49.47 µM -0.174091553035631 0.449395352494012 no 1886 0.430896755767186 2881 41316314 SGTC_2955 9076254 12.21 µM -0.174456636043272 0.449260384235298 no 1887 0.430753303768212 2778 16459619 SGTC_2060 5238662 140 µM -0.175994921196551 0.448691757218186 no 1888 0.430148966234429 2819 790130 SGTC_3251 9135047 49.47 µM -0.176591803152134 0.44847114815211 no 1889 0.429914516516566 2822 17682963 SGTC_1386 3228-0095 33.8 µM -0.177327631422078 0.448199206115767 no 1890 0.4296255239875 2853 870181 SGTC_3000 9075062 71.4286 µM -0.177389735412012 0.448176255288994 no 1891 0.429601134708455 2761 17057871 SGTC_106 0092-0003 11.579 µM -0.178860405374344 0.447632813023953 no 1892 0.429023656653371 2818 1072148 SGTC_2961 9083290 32.55 µM -0.179592367865208 0.447362374663284 no 1893 0.428736298411461 2726 17741490 SGTC_2361 9034121 116 µM -0.18023939029458 0.44712333949965 no 1894 0.428482317897149 2764 6496917 SGTC_1687 st020778 55.3625 µM -0.18062775728455 0.446979870899296 no 1895 0.428329883538779 2749 4259299 SGTC_1848 st056003 16.4 µM -0.181469668982287 0.446668879919119 no 1896 0.427999469260229 2710 146492 SGTC_2895 9054447 58.44 µM -0.181797063767455 0.446547953487086 no 1897 0.427870994449536 2737 2697450 SGTC_1697 st025554 27.742 µM -0.183342800837884 0.445977087859972 no 1898 0.427264526656321 2708 1269519 SGTC_2804 7954240 19.48 µM -0.187455204507019 0.444458859206263 no 1899 0.425651871343371 2888 828705 SGTC_2862 9027634 71.43 µM -0.187616654484712 0.444399271125521 no 1900 0.425588584848048 2709 5012562 SGTC_2964 9083345 53.42 µM -0.187969102663055 0.444269193651337 no 1901 0.425450435963264 2785 17741579 SGTC_2851 9015922 71.43 µM -0.188091314934753 0.444224090368494 no 1902 0.425402534634173 2914 2996893 SGTC_708 3448-5400 146 µM -0.188282865435211 0.444153398787011 no 1903 0.425327458271939 2771 3462195 SGTC_2337 9009472 200 µM -0.189783869097479 0.443599516093665 no 1904 0.424739248381449 2893 5742383 SGTC_387 norethindrone acetate 66.7 µM -0.190350108693249 0.443390597587045 no 1905 0.424517395153802 2800 541197 SGTC_2086 5274770 176.623 µM -0.193649983794467 0.442173397853536 no 1906 0.42322497875883 2820 689278 SGTC_2321 7390090 138.78 µM -0.194397502135897 0.441897741876057 no 1907 0.422932322810884 2840 649046 SGTC_921 1561-0023 372 µM -0.196024482537367 0.441297871595472 no 1908 0.422295501718606 2719 24050882 SGTC_3073 9114972 49.47 µM -0.19691064649213 0.440971198076072 no 1909 0.421948731048848 2853 41905075 SGTC_1232 0279-0259 161 µM -0.19743472714522 0.440778021028628 no 1910 0.421743678042725 2779 1560000 SGTC_2302 7771753 200 µM -0.198010678138475 0.440565740737529 no 1911 0.421518354599394 2826 2203047 SGTC_2218 6965428 192.983 µM -0.199086077430753 0.44016942278725 no 1912 0.421097705918708 2743 675684 SGTC_2234 tolnaftate 200 µM -0.200386641403854 0.439690204786872 no 1913 0.420589103114106 2789 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2206 7254556 146.969 µM -0.200450984578988 0.439666498585032 no 1914 0.42056394429523 2806 4398905 SGTC_1671 st016596 74.5 µM -0.200592284109275 0.439614439818551 no 1915 0.420508695918002 2787 2829167 SGTC_1090 efavirenz 20.7 µM -0.200903771640811 0.439499682640413 no 1916 0.420386909250408 2809 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_151 3013-0144 2.285 µM -0.204580624489829 0.438145455774841 no 1917 0.418949897319915 2993 906558 YHR107C CDC12 SGTC_2002 4023503 131 µM -0.204907284670142 0.438025177889888 no 1918 0.418822281818793 2815 4736863 YCR052W RSC6 SGTC_769 0302-0231 76 µM -0.205784051919152 0.437702376212444 no 1919 0.418479799655967 2850 571869 YER009W NTF2 SGTC_2906 7926292 26.41 µM -0.205957927640331 0.43763836485525 no 1920 0.418411887786231 2903 2966319 SGTC_1519 esterone 74 µM -0.206765486684343 0.437341088007726 no 1921 0.418096505649634 2763 698 A steroid. SGTC_1876 myriocin 605 nM -0.206808959031445 0.437325086065329 no 1922 0.418079529557212 2897 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2934 9036370 36.88 µM -0.207650651510695 0.437015283729052 no 1923 0.417750876037771 2878 6462800 SGTC_874 0599-0792 117 µM -0.209226313603848 0.436435432650008 no 1924 0.417135785848135 2925 765305 SGTC_214 4373-3496 70 µM -0.209405261349704 0.436369587648454 no 1925 0.417065942925607 2809 3779166 SGTC_2610 ononetin 44.17 µM -0.210013623030904 0.436145750158678 no 1926 0.416828520248004 2846 259632 SGTC_537 1334-0398 209 µM -0.210143629291001 0.436097918968851 no 1927 0.416777787198844 2927 5846986 SGTC_723 4182-0001 115 µM -0.213775082837712 0.434762234638197 no 1928 0.41536122839641 2801 744821 YLR208W SEC13 SGTC_1820 st053765 18.6 µM -0.213857524595535 0.434731920330807 no 1929 0.415329082177406 2839 3690829 SGTC_2450 5739737 12.93 µM -0.214064193380785 0.434655928719579 no 1930 0.415248499050739 2859 2262825 SGTC_968 1309-0633 340 µM -0.214941649542046 0.434333317131929 no 1931 0.414906406033625 2886 3761976 SGTC_1177 0983-0204 23.6 µM -0.21604522691486 0.433927630364957 no 1932 0.414476246973949 2920 766818 SGTC_3139 9095020 49.47 µM -0.217232508425907 0.433491250781796 no 1933 0.414013575732778 2729 25236292 SGTC_2972 9093619 59.92 µM -0.217322594478858 0.433458143390446 no 1934 0.413978474998259 2796 25236256 SGTC_1756 st041558 35.5 µM -0.217466052634802 0.433405422260806 no 1935 0.413922580010234 2972 3955792 SGTC_710 3448-4187 58 µM -0.219020942497432 0.432834073667115 no 1936 0.413316867024511 2824 3946412 SGTC_2283 7944793 200 µM -0.21912210492465 0.432796906103675 no 1937 0.413277465964669 2875 2970533 SGTC_2360 9040895 200 µM -0.219294298278621 0.432733642802774 no 1938 0.413210401565175 2857 4914414 SGTC_1659 st012954 42.1 µM -0.219707910240906 0.43258169010624 no 1939 0.413049321854834 2932 24207262 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.219709117037993 0.432581246767895 no 1940 0.413048851893395 2785 23665772 A membrane-active detergent. SGTC_3338 9144300 39.5675 µM -0.220336494852656 0.432350779888635 no 1941 0.412804549843774 2864 4901274 SGTC_3292 9120825 59.784 µM -0.220682176335789 0.432223803824121 no 1942 0.412669955275663 2887 24824900 SGTC_228 caffeine 993.056 µM -0.220763170364734 0.432194054029003 no 1943 0.41263842091858 2926 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1524 corynanthine 62.1 µM -0.22110886001742 0.432067083606156 no 1944 0.412503835845102 2986 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2299 7976368 114.88 µM -0.222212873324651 0.431661630995258 no 1945 0.41207408658223 2945 2979718 SGTC_41 0478-0632 82.643 µM -0.222907648389678 0.431406509386276 no 1946 0.411803691797009 2807 3750424 SGTC_484 loperamide 105 µM -0.223748066896224 0.431097945709795 no 1947 0.411476671001835 2764 3955 An opioid-receptor agonist. SGTC_350 k064-0020 19.8 µM -0.224812824031236 0.43070707544044 no 1948 0.411062444648036 2991 2790705 SGTC_852 0418-0143 439 µM -0.224829280262443 0.430701034921651 no 1949 0.411056043397187 2907 5369229 SGTC_2279 7948423 32.93 µM -0.226665287980376 0.430027201513007 no 1950 0.410342010389737 3007 1247112 SGTC_112 phenothiazine 287.218 µM -0.227375142073986 0.429766732387169 no 1951 0.410066023930211 2814 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_735 3076-0345 636 µM -0.227382966785199 0.429763861409954 no 1952 0.410062981983489 2960 2888990 SGTC_765 1319-0117 244 µM -0.228155562715561 0.429480405322753 no 1953 0.409762653083628 2794 3487746 YGL099W LSG1 SGTC_438 sphingosine 6.67 µM -0.228539606425864 0.429339517855585 no 1954 0.40961338460921 2798 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_341 1486-1430 230 µM -0.229964829990115 0.42881674957572 no 1955 0.409059549467445 2793 2054753 YPL210C SRP72 SGTC_1401 3807-4679 7.6 µM -0.232250390502105 0.427978672971269 no 1956 0.408171770793472 2795 3291456 SGTC_2978 9011784 42.97 µM -0.232556766596478 0.42786635461394 no 1957 0.408052801054635 2948 2994934 SGTC_2563 tomatine 8.54 µM -0.233397197104303 0.427558280405645 no 1958 0.407726494734733 2865 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_809 3998-0021 90 µM -0.233654108797391 0.427464113826069 no 1959 0.407626758727448 2988 715485 SGTC_2812 7970281 58.44 µM -0.234529777029981 0.427143183714337 no 1960 0.407286859492118 2954 2233435 SGTC_2145 5634607 200 µM -0.234859913219055 0.42702220217016 no 1961 0.407158731988411 2812 308662 SGTC_2115 tiliquinol 12.7705 µM -0.236330457658692 0.426483390721943 no 1962 0.406588127209321 2927 71208 A bioactive hydroxyquinoline. SGTC_2885 9057732 51.95 µM -0.236567174133275 0.426396669959349 no 1963 0.406496294315078 2982 6471414 SGTC_630 4356-0227 183 µM -0.238647935052854 0.425634539563587 no 1964 0.405689296021212 2838 779312 SGTC_2395 5646831 180.19 µM -0.238746177012034 0.42559856284883 no 1965 0.405651203928085 3000 6808628 SGTC_2286 7945697 125 µM -0.238997649699663 0.42550647506965 no 1966 0.405553702604361 2893 1245733 SGTC_161 4065-0411 162.148 µM -0.239791168669677 0.425215919880172 no 1967 0.405246076823541 2962 1906281 YLR208W SEC13 SGTC_236 1509-0011 5.31 µM -0.240040935826429 0.425124473445232 no 1968 0.405149260973676 2932 3107280 SGTC_3195 9113082 49.47 µM -0.24030309149099 0.425028495579626 no 1969 0.405047649279071 2874 17018038 SGTC_2070 5230947 200 µM -0.240931687017691 0.424798378451059 no 1970 0.40480403135932 2930 2835538 SGTC_677 0929-0063 136 µM -0.240997497524085 0.424774287929449 no 1971 0.404778528030222 2825 1539583 SGTC_3173 9105693 49.47 µM -0.241667511937543 0.424529039196559 no 1972 0.404518902588122 2996 17096658 SGTC_1956 st077085 54 µM -0.242203393862696 0.424332908673284 no 1973 0.404311282705221 2876 24208685 SGTC_856 0433-0016 11.3 µM -0.243518065913542 0.42385182371143 no 1974 0.403802045844019 2901 3911780 SGTC_1269 0831-0796 3.05 µM -0.243851899520753 0.423729680233495 no 1975 0.403672761659275 2950 927758 SGTC_983 1491-0821 12.2 µM -0.243896927892935 0.42371320575422 no 1976 0.403655324266928 2987 46495113 SGTC_279 1273-0055 2.93 µM -0.244404886168849 0.423527368881035 no 1977 0.403458628946608 2902 2847562 SGTC_840 0245-0196 390 µM -0.244712917865392 0.423414683561889 no 1978 0.403339362549373 2969 3827528 SGTC_3272 9137413 49.47 µM -0.245405923467508 0.423161188545695 no 1979 0.403071071479927 2816 17614870 SGTC_831 k061-1017 217 µM -0.245488696546778 0.423130913046023 no 1980 0.403039029652561 2896 1240153 SGTC_919 tnp00227 403.569 nM -0.246098042362844 0.422908049623895 no 1981 0.40280316922745 2861 1269246 A methoxyflavone. YNL221C POP1 SGTC_1740 st038286 13.222 µM -0.246728547351336 0.422677473371627 no 1982 0.402559155919976 3051 716786 SGTC_147 4466-0538 29.23 µM -0.247918949978917 0.422242214319971 no 1983 0.402098558786265 3049 6742687 YHR072W ERG7 SGTC_920 mycophenolic acid 780.421 nM -0.248593432880163 0.421995638362692 no 1984 0.401837644432813 2879 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_512 prima-1 270 µM -0.250960978756825 0.42113035885015 no 1985 0.400922139159536 3002 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2260 7964312 200 µM -0.251682040378375 0.42086690410342 no 1986 0.40064341996708 3020 231951 SGTC_2811 7967822 32.47 µM -0.251981027693804 0.42075767330248 no 1987 0.40052786422237 3006 2232244 SGTC_2767 sibutramine 71.45 µM -0.253106983866752 0.420346375901035 no 1988 0.400092771107622 3040 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2827 7993847 71.43 µM -0.25320519188887 0.420310505882214 no 1989 0.400054827336079 2956 2985692 SGTC_1652 st011932 78 µM -0.25448887039749 0.419841709304624 no 1990 0.399558950632091 2955 1551076 SGTC_2930 9013230 14.89 µM -0.254831406564608 0.419716635041442 no 1991 0.399426658470952 2993 2995857 SGTC_691 1548-0686 185 µM -0.256278361047743 0.419188381143901 no 1992 0.398867952409256 2874 46495133 SGTC_2067 5224629 34.075 µM -0.256543622550752 0.419091555288107 no 1993 0.398765550607377 3005 2835000 SGTC_1970 st070122 35.8 µM -0.256632992360203 0.41905893458917 no 1994 0.398731051770493 3032 102928 SGTC_3123 9126162 49.47 µM -0.256859686414021 0.41897619193331 no 1995 0.398643546112743 2833 25239884 SGTC_153 4077-0274 519.67 µM -0.2580596271474 0.41853827690613 no 1996 0.398180444674555 3173 3121976 SGTC_120 rhodamine 6G 52.259 µM -0.25871851265902 0.418297861369454 no 1997 0.397926217365812 2851 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2353 9059630 146.67 µM -0.260134211652896 0.417781401483137 no 1998 0.39738012449905 2972 4779114 SGTC_1826 st055655 41.6 µM -0.260411576211719 0.417680232947051 no 1999 0.39727315719567 2927 676168 SGTC_2836 9010338 19.48 µM -0.261064664732303 0.417442040877538 no 2000 0.397021320222464 2889 2994051 SGTC_37 0566-0070 1.56 µM -0.261178111597878 0.417400668034897 no 2001 0.396977578435912 2966 1626686 SGTC_2532 xanthone 78.9 µM -0.261304795111343 0.417354469010933 no 2002 0.396928734517581 2975 7020 An insecticide. SGTC_3015 9080845 49.47 µM -0.262528661104552 0.416908207629434 no 2003 0.396456945826554 2998 5296973 SGTC_1120 ficusin 1.78878 µM -0.262908674274362 0.416769664209261 no 2004 0.396310485172184 3014 6199 A DNA cross-linker. SGTC_1634 st006576 41 µM -0.262977089403234 0.416744722839769 no 2005 0.396284118890904 3054 3915356 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.263229535704811 0.416652694100695 no 2006 0.396186833547298 2860 229346 A bile salt which induces apoptosis. SGTC_2871 9038510 12.99 µM -0.263255277691198 0.416643310173236 no 2007 0.396176913709652 3061 4945164 SGTC_2011 4012611 177 µM -0.263472944761053 0.416563964194794 no 2008 0.39609303701242 2875 2049887 SGTC_551 k048-0028 34.9 µM -0.26399853546662 0.416372385114936 no 2009 0.395890523630216 3037 6836383 SGTC_751 0833-0568 350 µM -0.264065646841582 0.416347924286153 no 2010 0.395864667220037 2946 6954252 SGTC_2825 7998094 58.44 µM -0.265912356155329 0.415674961045102 no 2011 0.395153354379269 2937 2987815 SGTC_1490 4089-0339 670 nM -0.265953288416521 0.415660047626826 no 2012 0.395137592097314 2943 742542 SGTC_1644 st010134 20.9 µM -0.268454613429998 0.414748936518781 no 2013 0.394174703112231 2941 3818134 SGTC_1637 st007924 17.4 µM -0.268666471189564 0.414671788025201 no 2014 0.394093177748222 2865 683336 SGTC_1263 0774-1208 64.8 µM -0.269001621376752 0.414549749031298 no 2015 0.393964217482203 3039 906585 SGTC_2239 6685329 187.64 µM -0.269845352379123 0.414242555901056 no 2016 0.39363961520909 3013 805680 SGTC_1667 st014849 34.6 µM -0.270780766302204 0.413902043354176 no 2017 0.393279826842578 2845 5348460 SGTC_3130 9127414 49.47 µM -0.271008146302142 0.413819281484716 no 2018 0.39319238340226 2857 1494646 SGTC_1342 1486-1464 234 µM -0.27148858782101 0.41364442276842 no 2019 0.393007637915309 2883 3253938 SGTC_150 3970-0969 77.2 µM -0.271763266623785 0.413544459951121 no 2020 0.392902025749956 2985 6615640 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.274106457423246 0.412691939803785 no 2021 0.392001405759328 2932 2374 Ca(2+)-ATPase inhibitor. SGTC_1833 st055984 71 µM -0.274269869952823 0.412632500939419 no 2022 0.39193861865225 2921 676288 SGTC_205 1486-1330 71.903 µM -0.274947206687275 0.412386151205511 no 2023 0.391678399266696 2882 4118834 SGTC_2953 9074162 66.49 µM -0.275222519423799 0.412286028862245 no 2024 0.391572643399497 3010 16451992 SGTC_625 k213-0058 121 µM -0.275687274162262 0.412117025540837 no 2025 0.391394135370485 2950 3655420 SGTC_222 nsc-310342 10.666 µM -0.276292726251313 0.411896883511282 no 2026 0.391161621089627 2958 432556 SGTC_2309 7664088 163.95 µM -0.276301504883561 0.411893691809419 no 2027 0.391158250080871 3075 704922 SGTC_782 0083-0095 30.5 µM -0.276584020799337 0.41179097885611 no 2028 0.391049767886624 2843 3591729 An indicator and reagent. SGTC_1347 1493-0251 600 nM -0.276739489911132 0.41173445827612 no 2029 0.390990073518698 3023 3986378 SGTC_132 0417-1715 25.805 µM -0.277847714147785 0.411331618012835 no 2030 0.390564631030854 3021 6769098 SGTC_2368 9071271 200 µM -0.278112629580837 0.411235334898896 no 2031 0.390462950522073 2915 27209959 SGTC_1196 1588-0294 184 µM -0.280775541803857 0.410267801385534 no 2032 0.389441282057506 2951 6144269 SGTC_2307 7538926 6.34 µM -0.281279634147131 0.410084707456567 no 2033 0.389247964796921 2939 96582 SGTC_605 1315-0399 119 µM -0.282400495568733 0.409677664011833 no 2034 0.388818217522233 3037 24020461 SGTC_2131 toluylene red 5.2905 µM -0.28259570830723 0.409606781989366 no 2035 0.388743385282314 2931 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1047 2043-3044 82 µM -0.282866297324717 0.409508535619388 no 2036 0.38863966536296 2923 669592 SGTC_1030 k029-0042 36.7 µM -0.284091009021218 0.409063934331956 no 2037 0.388170318496978 2966 6080581 SGTC_1168 k815-0004 80.5 µM -0.286920465858812 0.408037218181903 no 2038 0.387086609774823 2892 642433 SGTC_1067 clotrimazole 1.36 µM -0.287060639752334 0.407986370070101 no 2039 0.387032944645713 2921 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_603 3794-0023 45.9 µM -0.287777247581195 0.407726444646218 no 2040 0.386758627376763 3022 3802260 SGTC_3258 9138477 49.47 µM -0.290626022312787 0.406693549983524 no 2041 0.385668677896045 2948 4970355 SGTC_269 exalamide 29 µM -0.291450053166146 0.406394897605149 no 2042 0.385353569137708 2930 3316 A derivative of salicylamide. SGTC_1304 1165-0502 251 µM -0.291662541319151 0.40631789463675 no 2043 0.385272326097051 2945 767425 SGTC_1946 st076057 65.1 µM -0.292098147848132 0.406160047774283 no 2044 0.385105791384545 2890 953009 SGTC_1395 3486-0190 4.35 µM -0.296134704445777 0.404698085364265 no 2045 0.383563605814296 3091 6748079 SGTC_317 4495-0002 170 µM -0.296433965765082 0.404589751410132 no 2046 0.383449344685883 2965 15991618 SGTC_322 k048-0136 19.3 µM -0.298387921107009 0.403882590854984 no 2047 0.382703553488471 3010 6823282 SGTC_2420 aureobasidin a 50 nM -0.299438559799083 0.403502481419567 no 2048 0.382302722285428 3200 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2194 5927483 104.545 µM -0.299766842667318 0.403383730985985 no 2049 0.382177504286054 2926 760979 SGTC_2654 protoveratrine a 100 µM -0.30003167505614 0.403287939115317 no 2050 0.382076497387981 2939 5702278 A heart drug and vasodilator. SGTC_700 3453-2283 142 µM -0.301520814895246 0.402749414220447 no 2051 0.381508690059339 3118 565664 SGTC_2517 totarol 10 µM -0.301553476861923 0.402737604577885 no 2052 0.381496238941016 3024 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2162 5663267 200 µM -0.30177570648186 0.402657254994703 no 2053 0.381411525703769 3094 6456493 SGTC_567 1080-0542 68.4 µM -0.302500005285877 0.402395405285629 no 2054 0.381135464712289 2975 5950415 SGTC_217 ketoconazole 989 nM -0.303316655649384 0.402100221010819 no 2055 0.380824277168585 3028 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2229 7354935 190 µM -0.304466992229127 0.401684518142063 no 2056 0.380386068086431 3030 318112 SGTC_1761 st044296 37 µM -0.304830832397358 0.401553058536025 no 2057 0.380247498773496 2927 1826700 SGTC_1947 st076332 61.6 µM -0.304913457966658 0.401523206526399 no 2058 0.380216032787827 3037 24208416 SGTC_2421 5690543 90.72 µM -0.306484800570428 0.400955601598998 no 2059 0.379617775391939 3044 3397993 SGTC_2552 juarezic acid 87.02 µM -0.306635628625227 0.400901130027344 no 2060 0.379560365744595 2912 1549512 SGTC_2080 5212524 12.4 µM -0.307242695222785 0.400681907339459 no 2061 0.379329324988267 3022 260183 SGTC_3264 9137442 49.47 µM -0.307273505037161 0.400670782193691 no 2062 0.379317600367329 3181 17015726 SGTC_737 1950-0117 57.9 µM -0.309407701913593 0.399900339543287 no 2063 0.378505706183829 3089 5393513 SGTC_72 0744-0168 198.391 µM -0.311207809113522 0.399250805561324 no 2064 0.377821323397078 2911 677577 SGTC_1973 st070275 50.2 µM -0.311213449366544 0.399248770821997 no 2065 0.377819179630499 2976 17118334 SGTC_946 3434-1334 87.4 µM -0.312604072941541 0.398747182579722 no 2066 0.377290741677122 3106 4047976 SGTC_932 2857-0803 154 µM -0.31298180416745 0.398610966395381 no 2067 0.377147243167338 3180 674898 SGTC_3235 9132602 49.47 µM -0.312982830507972 0.398610596296676 no 2068 0.377146853287976 3072 4912240 SGTC_695 3505-6186 243 µM -0.313606737741727 0.398385632045218 no 2069 0.376909870779443 3063 1819379 SGTC_334 1502-1024 68.5 µM -0.313927852018995 0.398269859987611 no 2070 0.376787918042328 3046 3296216 SGTC_2936 9038235 15.59 µM -0.314442424886438 0.398084358541546 no 2071 0.376592519265614 2912 4749415 SGTC_1449 4112-4002 201 µM -0.315511673289815 0.397698972502817 no 2072 0.376186594674147 2986 2059539 SGTC_3339 9145883 14.936 µM -0.316008070645427 0.397520091375848 no 2073 0.375998191156079 3099 2030670 SGTC_1787 fluconazole 80 µM -0.316244047388564 0.397435062647741 no 2074 0.375908638492129 3048 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2690 usnic acid 100 µM -0.317876483038748 0.396846986124001 no 2075 0.375289315951983 3211 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.318083314821627 0.396772492752152 no 2076 0.375210869858872 3003 1241132 A phosphatase inhibitor. SGTC_76 0433-0009 400.328 µM -0.321086573212717 0.395691252837509 no 2077 0.374072392532739 3083 2841569 SGTC_95 0471-0001 561.058 µM -0.322762309707767 0.395088298526041 no 2078 0.373437629511036 2978 4015405 SGTC_1017 4239-0030 168 µM -0.323176989933462 0.394939129268138 no 2079 0.373280603032262 2989 1149593 SGTC_423 5-fluorouracil 457 µM -0.323676269884885 0.394759548130102 no 2080 0.37309156919572 2895 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1290 0986-0249 10.2 µM -0.323912121924979 0.394674724582398 no 2081 0.373002283188304 3032 53329 SGTC_1068 loratadine 26.9 µM -0.32555974131489 0.394082302214911 no 2082 0.372378737908763 3024 3957 A H1 histamine antagonist. SGTC_2228 7354201 200 µM -0.326552864358671 0.393725330524318 no 2083 0.372003049672231 3008 753451 SGTC_2197 6588183 93.1375 µM -0.327529070705663 0.393374526449137 no 2084 0.371633879570073 2992 884136 SGTC_2041 5107442 45.335 µM -0.329055863249104 0.392826040409356 no 2085 0.371056732082279 3144 793005 SGTC_1299 1079-1439 3.74 µM -0.329405972717038 0.392700296780567 no 2086 0.370924426953762 3011 323161 SGTC_1148 3909-7663 27.7 µM -0.330975588854774 0.392136698833057 no 2087 0.370331462312901 3115 4084526 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.332070021999054 0.391743857374493 no 2088 0.369918192959055 2988 4620898 SGTC_1242 0402-0103 60.1 µM -0.332588279958631 0.391557869675732 no 2089 0.369722545720508 2960 432868 SGTC_1635 st007035 42.4 µM -0.332807359345176 0.391479255910686 no 2090 0.369639851335386 3067 3716403 SGTC_867 0518-0118 155 µM -0.333689910413923 0.391162608953845 no 2091 0.369306781971908 3083 6848158 SGTC_838 0109-0203 71.4 µM -0.333766005057729 0.391135310636504 no 2092 0.369278068909068 2980 759422 SGTC_2524 avocatin b 10.57 µM -0.334134170441832 0.391003241959543 no 2093 0.369139158056109 3085 6710748 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.334957486669086 0.390707946591999 no 2094 0.368828578107978 3137 5282362 SGTC_3322 9139058 2.11 µM -0.33743421648105 0.38982000889603 no 2095 0.367894797272113 3179 4908926 YPR165W RHO1 SGTC_754 3474-0146 171 µM -0.337464702420724 0.389809082887874 no 2096 0.367883308261485 2974 24762078 SGTC_1968 st069590 43.6 µM -0.341498336899656 0.388364219560601 no 2097 0.366364228333193 3131 6384066 SGTC_986 1493-0483 84 µM -0.343089290273331 0.387794757295631 no 2098 0.365765643913072 3121 40079 SGTC_872 0588-0139 234 µM -0.343878064843047 0.387512514479985 no 2099 0.365468994359109 3013 2047100 SGTC_351 caspofungin 25 nM -0.344842187889256 0.38716760843416 no 2100 0.365106507431418 3045 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_316 k060-0003 58.6 µM -0.345553451584434 0.386913217538103 no 2101 0.36483916671905 3136 6152314 SGTC_476 mead acid 10 µM -0.348054362728471 0.386019126860985 no 2102 0.36389967860765 2997 5312531 An omega 9 fatty acid. SGTC_2693 st077581 40.7 µM -0.348304517829477 0.385929728127645 no 2103 0.363805750645092 3153 25238761 SGTC_482 fipronil 114 µM -0.349876735352121 0.385367998546384 no 2104 0.363215603691267 3072 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2177 5811945 192 µM -0.351619593025341 0.384745582798529 no 2105 0.362561784658779 3161 5343475 SGTC_1776 st049249 45.9 µM -0.35280079050683 0.384323917913971 no 2106 0.362118895548203 3062 1822314 SGTC_1596 piperlongumine 63 µM -0.353610554195077 0.38403492681719 no 2107 0.361815381838468 3179 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_579 4491-1009 110 µM -0.353716688852124 0.383997053910978 no 2108 0.361775607134752 3152 1271041 SGTC_1487 3970-0795 2.82 µM -0.354548102082125 0.383700412216751 no 2109 0.361464080915868 3127 3765103 SGTC_109 0132-0036 33.701 µM -0.35479527918491 0.383612234505903 no 2110 0.361371482636928 2971 67274 A color developer. SGTC_2602 kawain 100 µM -0.35608600635378 0.383151879802275 no 2111 0.36088807831147 3095 5369129 SGTC_2396 5342950 42.78 µM -0.3566201098267 0.382961433039942 no 2112 0.360688110323194 3116 1886677 SGTC_2998 9066762 71.4286 µM -0.358367581890916 0.382338529977215 no 2113 0.360034124340038 3231 4945196 SGTC_1178 0988-0033 191 µM -0.358870960661693 0.382159152212758 no 2114 0.359845812280693 3166 5392207 SGTC_1839 st053978 48 µM -0.361310455008609 0.381290203419371 no 2115 0.358933689458933 3130 3788398 SGTC_974 1326-0144 138 µM -0.361327866118624 0.381284003720066 no 2116 0.358927182356854 3073 5411856 SGTC_1421 4029-0249 71.4 µM -0.361542374380303 0.381207624719148 no 2117 0.35884701695322 3188 2894095 SGTC_2213 7173844 200 µM -0.364550307390723 0.380137092043599 no 2118 0.357723557241874 3068 892728 SGTC_177 1327-0068 8.361 µM -0.364687590058187 0.380088254551849 no 2119 0.357672311627375 3152 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1164 k060-0068 93.7 µM -0.364886925496711 0.380017345559886 no 2120 0.357597907187186 3043 5963676 SGTC_950 1165-0508 94.1 µM -0.365508999123345 0.379796083135099 no 2121 0.357365745249947 3117 6148369 SGTC_2755 lomerizine 42.69 µM -0.366709537628598 0.379369180574996 no 2122 0.35691784573687 3088 3949 A calcium channel blocker. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.368368075860025 0.378779658693171 no 2123 0.356299399112025 3237 165506 SGTC_1011 4112-3381 17.4 µM -0.368633008845539 0.378685515225613 no 2124 0.356200644110727 3218 2877139 SGTC_1808 st050063 61.5 µM -0.37131229208013 0.377733842056355 no 2125 0.355202471801904 3204 4011993 SGTC_2482 5981709 142.65 µM -0.372710335839497 0.377237555305112 no 2126 0.354682021495088 3084 877755 SGTC_2782 7736369 71.43 µM -0.373001557082676 0.377134201157868 no 2127 0.354573642537769 3082 2950836 YOL077C BRX1 SGTC_515 4092-1064 102 µM -0.373180571626418 0.377070673430995 no 2128 0.354507027519811 3268 717353 SGTC_471 1-acyl-paf 4 µM -0.373681082467094 0.376893072473867 no 2129 0.354320800693928 3060 16759367 SGTC_843 0310-0051 143 µM -0.374156546903102 0.376724383089623 no 2130 0.354143925227567 3103 2065037 SGTC_1129 3453-1384 223 µM -0.374283559786802 0.376679324342155 no 2131 0.35409668103821 3249 1084452 SGTC_499 genistein 192 µM -0.374766804722166 0.376507905034414 no 2132 0.35391695197006 3134 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_349 k015-0014 24 µM -0.376016483430711 0.376064725094492 no 2133 0.353452320881969 3002 2196908 SGTC_2297 7971671 152.32 µM -0.376861356273965 0.37576519606036 no 2134 0.353138320423577 3242 909016 SGTC_1821 st053465 65.6 µM -0.379789560371523 0.374727653107194 no 2135 0.352050816182757 3131 675086 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.382480385941062 0.373775018547998 no 2136 0.351052537375051 3052 442882 SGTC_755 1995-0008 37.3 µM -0.384187954589826 0.37317088628935 no 2137 0.350419572699988 3200 689533 SGTC_3121 9125696 49.47 µM -0.384753969146048 0.372970700879734 no 2138 0.350209852913265 3122 1235365 SGTC_1662 st014054 52 µM -0.385485616697968 0.372711985980784 no 2139 0.349938830443445 3113 2838777 SGTC_2123 5259487 200 µM -0.385662811200602 0.372649337588671 no 2140 0.349873204195133 3195 2173474 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.386103766221169 0.372493449392719 no 2141 0.349709910338406 3107 65057 A dermal irritant. YDR527W RBA50 SGTC_982 1491-0518 27.5 µM -0.387365642838762 0.372047461172053 no 2142 0.349242767621101 3073 3091256 SGTC_776 4476-4378 112 µM -0.390003590085555 0.371115679815225 no 2143 0.348266946110929 3165 2892008 SGTC_2462 5162487 171.77 µM -0.392182284052257 0.370346685905158 no 2144 0.347461766529577 3190 2259986 SGTC_1143 3454-2408 5.08 µM -0.392856649049369 0.370108766199827 no 2145 0.347212680786218 3171 X1143 SGTC_152 4469-0003 551.229 µM -0.392877162378806 0.370101529761982 no 2146 0.347205104946832 3204 697280 SGTC_3354 9151612 71.43 µM -0.394296235930265 0.36960103835288 no 2147 0.346681170979346 3207 27261949 SGTC_1779 st039427 55 µM -0.396825687831052 0.368709477048113 no 2148 0.345748003283617 3313 1124498 SGTC_1757 st041620 31.8375 µM -0.397051609368248 0.368629880285778 no 2149 0.345664701573543 3164 5289815 SGTC_2682 pyrogallin 40.03 µM -0.397236405460167 0.368564777046275 no 2150 0.345596569178672 3134 822798 An ATP competetive kinase inhibitor. SGTC_1563 conessine 56.1 µM -0.397239061983211 0.368563841186799 no 2151 0.345595589782747 3190 441082 An anti-amoebic, histamine inhibitor. SGTC_1275 0867-0008 21.1 µM -0.398020033529297 0.368288748611849 no 2152 0.34530770926265 3062 3422836 SGTC_359 0081-0058 15.9 µM -0.39865193816061 0.36806621337306 no 2153 0.345074843035351 3449 3494159 SGTC_2189 6047310 154.431 µM -0.400045341533021 0.367575660793617 no 2154 0.344561560608376 3090 711535 SGTC_1262 0737-0114 49.6 µM -0.400079204730855 0.367563741820323 no 2155 0.344549090114417 3274 765919 SGTC_203 k066-0004 30.888 µM -0.40014919329765 0.367539108052073 no 2156 0.344523316592628 3197 6795412 SGTC_1702 st027038 51 µM -0.401837968403732 0.366944877927581 no 2157 0.343901638640402 3153 5521182 SGTC_428 3448-4153 16.5 µM -0.402206504694461 0.36681524319069 no 2158 0.343766027746364 3025 3834874 SGTC_758 0868-0029 16 µM -0.405652740672367 0.365603746952992 no 2159 0.342498885586247 3218 762687 SGTC_1604 st002052 72.4 µM -0.406787749691171 0.365205036371567 no 2160 0.342081942447681 3247 6254834 YHR062C RPP1 SGTC_1515 3460-0031 42.1 µM -0.407304863321848 0.365023430866737 no 2161 0.341892045651123 3165 2876596 SGTC_654 1124-0271 80.9 µM -0.408419386117483 0.364632123789521 no 2162 0.341482901609699 3136 5403748 SGTC_953 1188-0045 9.7 µM -0.409754969132375 0.364163388584085 no 2163 0.340992851114982 3215 6144426 SGTC_2907 7721985 69.9 µM -0.40991335268204 0.364107815871884 no 2164 0.340934754984127 3188 3267881 SGTC_2379 9035213 200 µM -0.411710339900159 0.363477499674203 no 2165 0.340275872665889 3268 646551 SGTC_2089 5281248 129.67 µM -0.413690724995757 0.362783282246254 no 2166 0.339550310276262 3155 2737878 SGTC_293 4049-0273 38.5 µM -0.415654111165632 0.362095468655079 no 2167 0.338831562408222 3153 1380311 SGTC_2508 celastrol 40.54 µM -0.415890120234512 0.362012819863254 no 2168 0.338745204665221 3175 122724 Celastrol is a natural product and antioxidant. SGTC_463 ikarugamyin 104 µM -0.416475679987339 0.36180778856032 no 2169 0.338530979939548 3207 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3072 9116419 49.47 µM -0.417274341670048 0.361528204453086 no 2170 0.338238876937237 3168 17170162 SGTC_3268 9137683 49.47 µM -0.41810703366351 0.361236786208207 no 2171 0.337934431310431 3121 1953228 SGTC_2951 9072950 58.06 µM -0.422371177097526 0.359745723647017 no 2172 0.336377056305514 3229 16488155 SGTC_333 3486-0131 40.1 µM -0.422398984849442 0.359736006956809 no 2173 0.336366909370243 3292 6744690 SGTC_128 0906-2981 13.371 µM -0.422884958476435 0.359566210849977 no 2174 0.336189598823326 3301 6740226 SGTC_2423 st077119 87.2 µM -0.424664161799721 0.358944805231835 no 2175 0.335540756397698 3193 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1967 st070177 51.4 µM -0.425039801385637 0.358813656769967 no 2176 0.335403830211406 3298 5729214 SGTC_2461 5755302 26.15 µM -0.425818149272369 0.358541962229654 no 2177 0.33512018048506 3277 2788904 SGTC_178 4092-0806 87.505 µM -0.426471886688583 0.358313820231165 no 2178 0.334882014599121 3247 2169044 SGTC_891 0929-0073 133 µM -0.426904904080709 0.358162733184388 no 2179 0.33472429672016 3266 5603632 SGTC_1853 st056710 91.2 µM -0.427209394531033 0.358056504645382 no 2180 0.334613409651485 3294 269167 SGTC_1212 0520-0165 585 µM -0.428655684796743 0.357552083002896 no 2181 0.334086907516864 3511 5403258 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.429391239978652 0.357295639298075 no 2182 0.333819263862894 3223 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1862 st057513 3.81 µM -0.429610336017947 0.357219266180822 no 2183 0.333739558555876 3116 5393163 SGTC_2749 bexarotene 57.39 µM -0.430147980354385 0.357031876841785 no 2184 0.333543999840543 3207 82146 An retinoic acid receptor inhibitor. SGTC_2549 cedrol 20.94 µM -0.431388896702409 0.356599502381788 no 2185 0.333092810955014 3277 6708665 A sedative which affects the nervous system. SGTC_1898 st060199 18.6 µM -0.432683877490672 0.356148486585262 no 2186 0.332622222083401 3145 688866 SGTC_1502 4534-4282 27.7 µM -0.432973678453254 0.356047582258458 no 2187 0.332516946086884 3192 3278949 SGTC_2155 5570423 76 µM -0.433047476112153 0.35602188863625 no 2188 0.332490139720915 3152 797402 SGTC_1098 clofazimine 15.1 µM -0.435617004679999 0.355127682048132 no 2189 0.331557315556515 3279 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2139 5578692 56.4705 µM -0.437081754619717 0.35461829942634 no 2190 0.331026029376685 3238 650991 YMR113W FOL3 SGTC_2356 9061756 188.97 µM -0.43839746266824 0.354160969242408 no 2191 0.330549092730118 3218 20104043 SGTC_1311 1190-0148 100 µM -0.438658999740646 0.354070085962778 no 2192 0.330454319782918 3307 1961333 SGTC_1682 st012968 530 nM -0.43866503453085 0.354067988990963 no 2193 0.330452133089878 3152 24207270 SGTC_422 cantharidin 155 µM -0.438819464564823 0.354014329074085 no 2194 0.330396177674233 3124 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_665 3914-0008 307 µM -0.438935772457641 0.353973917399441 no 2195 0.330354037750119 3153 1069549 SGTC_220 paclitaxel 373.376 µM -0.439083452854975 0.353922607584314 no 2196 0.330300534242896 3253 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1369 1866-0067 208 µM -0.439583945699738 0.353748736973367 no 2197 0.330119235223105 3310 3531355 SGTC_1492 4158-0558 28.5 µM -0.440120502475687 0.353562371674672 no 2198 0.329924916667687 3258 3967268 SGTC_1847 st056231 15 µM -0.440579257951888 0.353403057371233 no 2199 0.329758810892102 3158 5393180 SGTC_318 1488-0629 67.2 µM -0.442098805109049 0.352875540197467 no 2200 0.329208854512382 3273 3662576 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.442610845803833 0.352697846749963 no 2201 0.329023619257341 3136 6708514 SGTC_286 k060-0067 22.9 µM -0.443204532739595 0.352491859840804 no 2202 0.328808900303701 3208 5985051 SGTC_457 grayanotoxin iii 135 µM -0.444498536933138 0.352043039275824 no 2203 0.328341093202467 3274 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_265 mycophenolic acid 32.932 µM -0.444910673517411 0.351900134459865 no 2204 0.32819215444797 3415 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2748 diazoxide 86.69 µM -0.446695151481255 0.351281623667114 no 2205 0.32754759153273 3221 3019 A potassium channel activatior. SGTC_3312 9133330 71.43 µM -0.447028519278743 0.351166119975801 no 2206 0.327427234200022 3316 17617324 SGTC_497 capsazepine 133 µM -0.448603885960814 0.350620480545878 no 2207 0.326858715022235 3208 2733484 A calcium channel blocker. SGTC_92 0063-0024 660.874 µM -0.451445886137524 0.349636913306441 no 2208 0.325834109080859 3265 3594437 SGTC_761 k216-0224 480 µM -0.453571431173164 0.348901957557587 no 2209 0.325068659912391 3358 1340404 SGTC_709 3807-1509 243 µM -0.453959516586679 0.348767829242922 no 2210 0.324928982528517 3254 1886677 YPL242C IQG1 SGTC_1458 k015-0034 6.33 µM -0.454027414610268 0.348744364578996 no 2211 0.324904547606001 3246 3598957 SGTC_1215 3852-0577 11.2 µM -0.455441614687749 0.348255767272416 no 2212 0.32439578119423 3345 2884876 SGTC_1750 st081859 2.357 µM -0.456799450156527 0.347786880441358 no 2213 0.323907600515965 3293 5291695 SGTC_1793 st048256 72.231 µM -0.458075447604415 0.347346465922124 no 2214 0.323449118821006 3248 672022 SGTC_732 3970-1727 52.7 µM -0.458581811171625 0.347171750018431 no 2215 0.323267250336066 3314 1275699 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.459185841484042 0.346963377617672 no 2216 0.323050358526765 3245 6708561 SGTC_1367 1812-0510 76.9 µM -0.4592340038107 0.346946765045686 no 2217 0.32303306725761 3252 1142582 YDR527W RBA50 SGTC_2305 7443522 69.23 µM -0.460497365241097 0.346511100500178 no 2218 0.3225796311193 3234 5415886 SGTC_864 0469-0573 172 µM -0.460499046270754 0.34651052093969 no 2219 0.322579027952399 3215 689425 SGTC_3030 9087619 49.47 µM -0.461915702690705 0.346022234996581 no 2220 0.32207088641786 3239 25236973 SGTC_543 3844-1095 191 µM -0.462524371312718 0.345812520735885 no 2221 0.32185266466552 3289 4230703 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.462534303383348 0.345809099073975 no 2222 0.321849104298085 3207 390807 SGTC_563 tetrahydrosecaminediol 614 µM -0.464696493055682 0.345064511106132 no 2223 0.321074410060371 3351 334274 A psychoactive constituent of the cannabis plant. SGTC_664 1222-0054 14.9 µM -0.465343609750165 0.344841781537343 no 2224 0.320842704768693 3246 6813991 SGTC_2195 6536160 144.242 µM -0.465461183017017 0.344801320040802 no 2225 0.320800614209935 3195 3834386 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.467709749105301 0.344027843768713 no 2226 0.319996084173422 3352 1377 SGTC_3300 9124615 50.48 µM -0.469889061336151 0.343278812122631 no 2227 0.319217139915946 3380 24824903 SGTC_1283 0922-0125 16.4 µM -0.4717174619794 0.342650863545032 no 2228 0.318564235722449 3284 3360884 SGTC_2795 7780010 54.55 µM -0.472423307814178 0.34240856299104 no 2229 0.318312335497636 3340 953673 SGTC_889 0919-1524 82.7 µM -0.472766032787076 0.34229093681388 no 2230 0.318190055081637 3295 3905452 SGTC_2593 nobiletin 86.24 µM -0.472848395081612 0.342262671641042 no 2231 0.318160672093343 3270 72344 An anti-infammatory. SGTC_1258 0671-0043 57.1 µM -0.47482739931273 0.341583781049289 no 2232 0.317455001005675 3270 4298767 SGTC_122 0236-0016 402.397 µM -0.474862692047365 0.341571678640028 no 2233 0.317442422371389 3296 6808838 SGTC_3043 9092303 49.47 µM -0.47561061509945 0.341315242898808 no 2234 0.317175905749842 3268 25236084 SGTC_1190 1486-1332 13 µM -0.475776268018552 0.341258456414214 no 2235 0.31711688942538 3288 4150046 SGTC_3263 9137018 49.47 µM -0.475994334515666 0.341183707825603 no 2236 0.317039207073178 3281 43844957 SGTC_1480 1070-0044 41.2 µM -0.478806038126622 0.340220474314895 no 2237 0.316038310360971 3308 3124987 SGTC_1597 7-benzyloxygramine 47.5 µM -0.478835697599427 0.340210319113326 no 2238 0.316027759491013 3313 260807 SGTC_1070 indatraline 8.81 µM -0.479233201835488 0.340074227557313 no 2239 0.315886368356933 3270 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.480601316084398 0.339605992402913 no 2240 0.315399939951134 3354 6708760 SGTC_1014 4130-3005 69.3 µM -0.48095338343632 0.339485537855565 no 2241 0.315274815289829 3215 743608 SGTC_2414 st077232 92.9 µM -0.483584225073871 0.338585954731619 no 2242 0.31434048618765 3175 729801 SGTC_2647 atorvastatin 60.16 µM -0.484850391284328 0.33815333283048 no 2243 0.313891237278791 3306 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3280 9140961 49.47 µM -0.484868034906278 0.33814730589022 no 2244 0.31388497908511 3219 4901226 SGTC_1331 1472-0049 76.2 µM -0.48671666078743 0.337516058071223 no 2245 0.313229568340219 3227 24051409 SGTC_3282 9108498 15.4605 µM -0.488217138934334 0.337004027654219 no 2246 0.312698022996465 3315 16459645 SGTC_2853 9015042 58.44 µM -0.490153521085544 0.336343693471441 no 2247 0.312012633801387 3175 6457456 SGTC_2572 astragaloside iv 100 µM -0.492037783954049 0.33570161697754 no 2248 0.311346316585826 3372 45006101 An anti-inflammatory agent. SGTC_6 0844-0013 19.835 µM -0.49314038700652 0.335326119033864 no 2249 0.310956697912755 3400 1584900 SGTC_933 2914-0560 114 µM -0.494025767263448 0.335024716616589 no 2250 0.310643990948167 3393 463887 SGTC_952 1185-0122 232 µM -0.496643040388486 0.334134362399386 no 2251 0.309720398012847 3304 678600 SGTC_1093 fluphenazine 7.97 µM -0.497232260319022 0.333934047687823 no 2252 0.309512637205733 3314 6602611 An atypical antipsychotic. SGTC_513 4245-1575 41.7 µM -0.499274563971392 0.333240100465257 no 2253 0.308792985900888 3294 719745 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.499789562211791 0.333065200984583 no 2254 0.308611630471967 3242 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3213 9129884 49.47 µM -0.499835548258418 0.333049585345473 no 2255 0.308595438862275 3331 17190742 SGTC_1906 st060206 94.7 µM -0.500225819464772 0.332917071273011 no 2256 0.308458040011182 3382 5133468 SGTC_1244 0416-0015 52.5 µM -0.501324247783916 0.332544219064055 no 2257 0.308071471447634 3280 96201 SGTC_652 0437-0092 114 µM -0.501364100628413 0.33253069446395 no 2258 0.308057450082336 3340 3091274 SGTC_616 4092-0450 108 µM -0.502526314067451 0.332136377605076 no 2259 0.307648673590425 3336 787165 SGTC_3234 9132280 49.47 µM -0.50321190193205 0.331903857809403 no 2260 0.307407648882923 3363 17612295 SGTC_1530 rhein 70.4 µM -0.50321766920902 0.331901902089363 no 2261 0.30740562169627 3358 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1900 st060200 72.8 µM -0.505532792663645 0.331117199552831 no 2262 0.306592336041495 3265 688945 SGTC_2587 piperic acid 92.2 µM -0.506406572431126 0.330821227591796 no 2263 0.306285630804918 3275 5370536 SGTC_2467 5474540 200 µM -0.507419651864021 0.330478203559868 no 2264 0.305930199890043 3278 5413519 SGTC_1031 k035-0009 16 µM -0.507582370928388 0.33042312089658 no 2265 0.305873128210707 3411 5180959 SGTC_2673 kobusone 100 µM -0.509422820797333 0.329800359062967 no 2266 0.305227941833564 3388 6710676 An epoxy ketone and protein crosslinker. SGTC_2941 9056145 11.23 µM -0.509669889756668 0.329716793017171 no 2267 0.305141375567174 3362 2119517 SGTC_926 2268-1401 59.4 µM -0.511027182087138 0.329257868222503 no 2268 0.304666011647832 3379 2931578 SGTC_2703 st077852 53.4 µM -0.511469250810239 0.329108452366643 no 2269 0.304511257232454 3376 6281836 SGTC_2160 5660466 132.927 µM -0.511535429772818 0.329086086730637 no 2270 0.304488093060533 3371 2859134 SGTC_210 3551-0445 56.827 µM -0.512699339372122 0.328692835527569 no 2271 0.304080825942915 3424 2865180 YOR207C RET1 SGTC_1292 0kpi-0043 232 µM -0.513698761986361 0.328355310985947 no 2272 0.303731308828136 3341 3333905 SGTC_2402 5553605 200 µM -0.514479163876008 0.3280918513777 no 2273 0.303458512150443 3459 6758546 SGTC_1762 st045503 25.4615 µM -0.514682930553713 0.328023074881843 no 2274 0.303387301653183 3360 4645554 SGTC_812 4251-0442 148 µM -0.515136127753795 0.327870130076615 no 2275 0.303228949257813 3393 5723007 SGTC_1405 3909-7894 12 µM -0.516959396590716 0.327255105944639 no 2276 0.302592251572186 3389 7104060 SGTC_2963 9082507 9 µM -0.517365567951473 0.327118160200642 no 2277 0.302450495456392 3404 16459611 SGTC_2677 mitomycin C 100 µM -0.518020638251125 0.326897344113014 no 2278 0.302221934958388 3376 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3192 9110362 49.47 µM -0.518274783242582 0.326811691295294 no 2279 0.302133282135381 3434 16649480 SGTC_121 0557-0495 61.343 µM -0.518293907195022 0.326805246444287 no 2280 0.302126611642587 3359 3104427 SGTC_1159 4092-0538 61.2 µM -0.52103979564601 0.325880407840317 no 2281 0.301169524560309 3382 717301 SGTC_2276 7947513 42.08 µM -0.521400974952575 0.325758839107059 no 2282 0.301043736221095 3331 2105100 SGTC_2546 rhodinyl acetate 100 µM -0.523842602576798 0.324937502262857 no 2283 0.300194009601108 3424 6708682 SGTC_59 0330-0160 1.33 µM -0.524205159594477 0.324815614442744 no 2284 0.300067926313553 3406 4293482 SGTC_312 4092-0653 6.84 µM -0.524686183823662 0.324653928151508 no 2285 0.299900681703787 3385 1148278 SGTC_1024 4507-0395 26 µM -0.524995853414588 0.32454985663669 no 2286 0.299793036753958 3475 4201836 SGTC_2975 9084847 53.72 µM -0.525173698418551 0.32449009396721 no 2287 0.299731223558427 3365 27211724 SGTC_1165 k072-0275 30.3 µM -0.52749032252326 0.323712033711809 no 2288 0.298926567531661 3445 6153523 YGL055W OLE1 SGTC_1861 st057647 17.4 µM -0.528458384086011 0.323387128892745 no 2289 0.298590612047726 3453 688668 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.528724792598642 0.323297739380659 no 2290 0.298498187942517 3417 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1732 st034308 51.822 µM -0.52877370540224 0.323281328507053 no 2291 0.298481220221473 3303 830119 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.530082370852256 0.3228423822059 no 2292 0.298027410702557 3239 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2585 alliin 100 µM -0.530621897719893 0.322661488466025 no 2293 0.297840409069571 3500 87310 A garlic compound which reacts with lipids. SGTC_22 0964-0034 14.468 µM -0.532099854973025 0.322166170770744 no 2294 0.297328418917812 3377 138402 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.534463109985147 0.321374813465916 no 2295 0.296510582841632 3322 4174840 SGTC_2281 7943571 200 µM -0.536169884364867 0.320803788217333 no 2296 0.295920572511988 3501 1244024 SGTC_3147 9097027 49.47 µM -0.537484262077765 0.320364333445171 no 2297 0.295466576518648 3343 25236841 SGTC_2867 9039098 71.43 µM -0.539389567264549 0.319727752524793 no 2298 0.294809039094285 3391 6463460 SGTC_2453 5731132 22.18 µM -0.542774418503145 0.31859815055089 no 2299 0.293642564274848 3469 1362040 SGTC_409 arachidonic acid 100 µM -0.544842933767221 0.317908668030029 no 2300 0.292930773673954 3372 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_510 ag-490 170 µM -0.545262315361045 0.317768955571458 no 2301 0.292786559212045 3503 5328779 SGTC_1023 4482-3888 16 µM -0.545601814495483 0.317655874092429 no 2302 0.29266983840808 3462 3303168 SGTC_1778 st046819 58.9 µM -0.545713346831673 0.317618728249356 no 2303 0.292631497979027 3371 671715 SGTC_1320 1313-0481 95.3 µM -0.54673920177915 0.317277153418339 no 2304 0.292278958891162 3483 6813365 YLR208W SEC13 SGTC_320 4092-0846 5.34 µM -0.546896046359569 0.317224943208493 no 2305 0.292225076049513 3393 1359356 SGTC_2709 st078560 56 µM -0.548687070114312 0.316629007796038 no 2306 0.291610110503818 3493 17250903 SGTC_1078 idebenone 36.1 µM -0.548883380843829 0.31656371733927 no 2307 0.29154274199959 3424 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2058 5236698 133 µM -0.549876717222243 0.316233433931656 no 2308 0.29120196729271 3356 766665 SGTC_1349 flufenamic acid 69 µM -0.552034263048707 0.315516557136303 no 2309 0.290462439385836 3397 3371 A non-steroidal anti-inflammatory. SGTC_1579 chlormadinone acetate 49.4 µM -0.553883722699639 0.314902598625601 no 2310 0.289829212784054 3476 45114258 A steroidal progestin. SGTC_3279 9140807 49.47 µM -0.557470591002289 0.31371333684278 no 2311 0.28860297345762 3452 45595718 SGTC_2614 arthonioic acid 13.39 µM -0.56108952081395 0.3125154033974 no 2312 0.287368255769522 3429 6710684 SGTC_2701 st077767 14.721 µM -0.561167631858698 0.312489568948276 no 2313 0.287341633174506 3426 5721188 SGTC_1513 0337-0559 19 µM -0.56121036165371 0.312475436884598 no 2314 0.287327070068071 3341 775073 SGTC_1461 k072-0203 53.8 µM -0.562805085204447 0.311948209878797 no 2315 0.28678380859867 3399 5418714 SGTC_144 4161-2749 112.381 µM -0.564675006410584 0.311330491026758 no 2316 0.286147418638105 3406 797501 YMR168C CEP3 SGTC_1742 st038235 28.8875 µM -0.564765104372464 0.311300741020491 no 2317 0.286116772561746 3428 564103 YBR002C RER2 SGTC_1786 berberine 21.6 µM -0.565166141050986 0.311168335179582 no 2318 0.285980382173493 3452 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3216 9129716 49.47 µM -0.567054859573192 0.31054508660234 no 2319 0.285338455126016 3388 8056934 SGTC_451 chloral hydrate 100 µM -0.567648384865859 0.310349344357125 no 2320 0.285136872902665 3486 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_899 1083-0020 478 µM -0.568262277449029 0.310146941561259 no 2321 0.284928444665876 3508 767123 SGTC_464 bw-b 70c 158 µM -0.568862041010729 0.309949252691244 no 2322 0.284724883708288 3492 5353454 SGTC_1653 st012112 65 µM -0.569925283229936 0.309598931040625 no 2323 0.284364187859201 3502 720429 SGTC_2635 hydroquinidine 100 µM -0.570143227272232 0.30952714323796 no 2324 0.2842902791788 3451 442912 An experimental heart treatment. SGTC_3158 9100007 49.47 µM -0.570902443976429 0.309277124347671 no 2325 0.284032887093247 3392 19297233 SGTC_3102 9121669 49.47 µM -0.571459518431676 0.309093729396869 no 2326 0.283844096863278 3409 41905072 SGTC_3079 9117512 49.47 µM -0.572066274718532 0.308894032767502 no 2327 0.283638538035896 3492 7185044 SGTC_2496 diffractaic acid 79.83 µM -0.572235141485586 0.308838465102894 no 2328 0.283581341502421 3565 94870 An apoptosis inducer which activates caspases. SGTC_999 SEC7.066 22.7 µM -0.572474574793092 0.308759684159909 no 2329 0.283500252987411 3451 740511 YDR170C SEC7 SGTC_1123 mangostin 811.285 nM -0.573154841825533 0.308535903350301 no 2330 0.283269928639306 3422 5281650 An antioxidant. SGTC_89 0302-0250 142.109 µM -0.575428752194258 0.307788393658883 no 2331 0.282500681691689 3535 4203518 YLR208W SEC13 SGTC_2512 diallyl trisulfide 49.23 µM -0.577165230560131 0.307218092209848 no 2332 0.281913921217723 3489 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.577859512247097 0.306990203636008 no 2333 0.2816794860801 3549 5393153 SGTC_1330 1469-0054 61.8 µM -0.577996039928984 0.30694539903938 no 2334 0.281633396421435 3487 7102664 SGTC_42 0133-0086 60.653 µM -0.578316739648822 0.306840165631859 no 2335 0.281525147403839 3435 162923 Model of phenazepam hydroxylation. SGTC_3310 9130229 44.1445 µM -0.580219377449027 0.306216167527944 no 2336 0.28088334392893 3477 7761258 SGTC_3108 9121785 49.47 µM -0.580836757744902 0.306013809183511 no 2337 0.280675239454501 3466 17140271 SGTC_962 1254-0300 21.5 µM -0.582229513475025 0.305557523971597 no 2338 0.280206048131917 3442 7340576 SGTC_585 0kpi-0023 191 µM -0.584550590273347 0.304797779317372 no 2339 0.279424969491602 3452 64601 SGTC_2826 7992541 19.48 µM -0.585156051973598 0.304599735200226 no 2340 0.279221396206983 3546 2985066 SGTC_2261 9010538 184.68 µM -0.5880209535317 0.303663414537964 no 2341 0.278259114276187 3457 6457250 SGTC_442 cape 100 µM -0.588740535178068 0.303428439488208 no 2342 0.278017670774332 3495 5281787 SGTC_2739 tacrine 100.86 µM -0.589649761029002 0.303131653493504 no 2343 0.277712741608268 3502 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3179 9107801 49.47 µM -0.590713411719685 0.302784625624484 no 2344 0.277356230071191 3479 4818259 SGTC_2161 5662504 8.5105 µM -0.591968999704742 0.302375205217074 no 2345 0.276935673724741 3465 2859334 SGTC_2383 9036125 200 µM -0.592533990254961 0.302191054915594 no 2346 0.276746533334043 3452 79580 SGTC_1022 4477-0945 21.3 µM -0.593142872446365 0.301992655157661 no 2347 0.276542770333393 3483 4648966 SGTC_1467 k284-1082 293 µM -0.593807654753393 0.301776107596336 no 2348 0.276320384326928 3503 3334705 SGTC_2913 7966556 36.57 µM -0.596235343371328 0.30098590087011 no 2349 0.275509008860973 3489 2976516 SGTC_3331 9141060 1.957 µM -0.596269634762918 0.300974745789819 no 2350 0.27549755648405 3441 4906567 YPR165W RHO1 SGTC_94 0334-0113 514.748 µM -0.596367693124121 0.30094284817446 no 2351 0.275464808994114 3460 6795178 SGTC_661 1304-0007 33.6 µM -0.597486054431576 0.30057916190165 no 2352 0.275091457484286 3494 3117130 SGTC_1246 0422-0085 105 µM -0.597987329912504 0.30041621371066 no 2353 0.274924193602534 3536 264295 SGTC_1170 0310-0127 64.8 µM -0.598270754961336 0.300324099203365 no 2354 0.274829643488692 3460 774975 SGTC_796 1234-0020 70.7 µM -0.60015125724136 0.299713250481155 no 2355 0.274202717403139 3493 46495034 SGTC_3205 9113483 49.47 µM -0.601798096371177 0.299178765883797 no 2356 0.273654271216826 3523 17018033 SGTC_1904 st060225 78 µM -0.604291530006936 0.298370341903477 no 2357 0.272824918291803 3520 66595 SGTC_1661 st013063 9.66 µM -0.604831709451034 0.298195335409361 no 2358 0.272645411064383 3546 721395 SGTC_2077 5212015 200 µM -0.606233543592939 0.297741389609311 no 2359 0.272179840676923 3464 780900 SGTC_3317 9138495 8.753 µM -0.606281046927006 0.297726012472461 no 2360 0.272164071023683 3544 17020139 SGTC_1154 4088-0362 150 µM -0.606296580778474 0.297720984142763 no 2361 0.272158914358892 3530 6618304 SGTC_904 1141-0088 396 µM -0.606326196130688 0.2977113977187 no 2362 0.272149083290653 3498 1378119 SGTC_2446 5162541 200 µM -0.60648512647087 0.297659954724812 no 2363 0.272096328027264 3479 1549321 SGTC_3088 9117578 49.47 µM -0.606911341132872 0.297522016462769 no 2364 0.2719548756351 3575 678341 SGTC_3296 9122258 64.045 µM -0.607438069151957 0.297351588825564 no 2365 0.271780115352577 3512 4730474 SGTC_2390 9097792 176.6 µM -0.608377400561997 0.297047770351316 no 2366 0.27146859835835 3445 4497149 SGTC_684 1140-0066 328 µM -0.610053881090743 0.296505880594081 no 2367 0.270913057868052 3541 6813534 SGTC_211 3455-0679 143.504 µM -0.612009909561795 0.295874205606257 no 2368 0.270265600607461 3552 748649 SGTC_2882 9058044 58.44 µM -0.61237242677217 0.295757203116452 no 2369 0.270145690255063 3504 18076804 SGTC_473 2-arachidonoylglycerol 10 µM -0.612945139892233 0.295572403195827 no 2370 0.269956307335638 3445 5282280 An endocannabinoid. SGTC_191 3914-0123 66.505 µM -0.613624788577034 0.295353166804133 no 2371 0.269731649558062 3419 3144412 SGTC_2291 7917025 104.35 µM -0.616346145469999 0.294476080764549 no 2372 0.268833044518182 3498 2964612 SGTC_483 fpl-64176 144 µM -0.618462724316455 0.293794745307119 no 2373 0.268135181003688 3562 3423 SGTC_3131 9127911 49.47 µM -0.619665508502535 0.293407889402732 no 2374 0.267739014121185 3606 45595681 SGTC_2733 amorolfine 100 µM -0.619879682845452 0.293339028481512 no 2375 0.267668501423662 3535 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_433 pimozide 108 µM -0.62140720891267 0.292848118579962 no 2376 0.267165865036799 3463 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_961 1252-1571 372 µM -0.623497610465351 0.292176932875178 no 2377 0.266478786014303 3569 6813498 SGTC_2656 pseudo-anisatin 100 µM -0.624231873075604 0.291941345967636 no 2378 0.266237658815691 3553 6708809 A neurotoxin. SGTC_546 peri-Naphthalide 147 µM -0.625192097283574 0.291633393218477 no 2379 0.265922494002549 3476 223824 A penicillin ester. SGTC_1607 st000305 50.6 µM -0.625894170805599 0.291408327656088 no 2380 0.265692179108115 3558 5457690 SGTC_818 4072-2707 53.5 µM -0.626009099182023 0.291371492482919 no 2381 0.265654486543029 3514 882871 SGTC_3353 9151644 39.2805 µM -0.627613752345023 0.290857419448829 no 2382 0.265128498734737 3562 4909158 SGTC_564 3555-0129 330 µM -0.628614481299064 0.290537036760567 no 2383 0.264800738700688 3490 563260 SGTC_1072 oxiconazole 14.9 nM -0.628665957146441 0.290520561270165 no 2384 0.264783884837181 3587 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1135 dihydrocapsaicin 536.708 nM -0.629433588920155 0.290274922987664 no 2385 0.264532616912123 3539 107982 A Capsaicinoid. SGTC_3309 9129340 25.759 µM -0.632730967228147 0.289220886606327 no 2386 0.263454671887148 3566 17158987 SGTC_2284 7945075 39.21 µM -0.633329204823383 0.289029847617965 no 2387 0.263259342772279 3591 1245402 SGTC_1512 0259-0544 12.2 µM -0.633578245704023 0.288950337323227 no 2388 0.263178050844973 3566 18476 SGTC_1316 1272-0050 65.9 µM -0.633987794290508 0.288819604752758 no 2389 0.263044393880774 3583 7340392 SGTC_3005 9076496 71.4286 µM -0.634319367584196 0.288713783183669 no 2390 0.26293620972033 3588 21368410 SGTC_3023 9089636 49.47 µM -0.634904806548123 0.288526985013418 no 2391 0.262745251027018 3650 17249241 SGTC_2034 5197015 53.07 µM -0.634923992056045 0.288520864386462 no 2392 0.262738994291803 3588 780676 SGTC_1911 st060208 74.3 µM -0.635472493470029 0.288345905455965 no 2393 0.262560150471424 3565 688783 SGTC_256 clotrimazole 625 nM -0.635765761278269 0.288252380514606 no 2394 0.262464553433074 3560 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_531 3788-1495 174 µM -0.636891902477348 0.287893380049561 no 2395 0.262097628808667 3555 2896655 SGTC_420 mitomycin C 81.9 mM -0.636915169921061 0.287885964891085 no 2396 0.262090050473598 3565 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2655 perillic acid 100 µM -0.63735261981044 0.287746569708269 no 2397 0.2619475915329 3537 5702197 An apoptosis inducer. SGTC_1326 1431-2094 10.8 µM -0.639423703334427 0.287087043800784 no 2398 0.261273666532506 3561 616278 SGTC_3267 9137951 49.47 µM -0.641090256887691 0.286556858668168 no 2399 0.260732022006268 3549 16643986 SGTC_25 0118-0223 35.662 µM -0.641450091529161 0.286442444511818 no 2400 0.260615148484199 3612 5333628 SGTC_1749 st037932 54.2 µM -0.642263441946747 0.286183908961525 no 2401 0.26035107341105 3567 594497 SGTC_2876 9059903 25.97 µM -0.642999421182812 0.285950062556042 no 2402 0.260112237731647 3572 6916095 SGTC_2391 6285546 200 µM -0.643683654316811 0.285732739208623 no 2403 0.259890295753726 3534 846083 SGTC_1452 4194-0072 190 µM -0.643850027906936 0.285679908182142 no 2404 0.259836344582774 3626 1343545 SGTC_1286 0929-0070 131 µM -0.644239305880581 0.285556313245833 no 2405 0.259710133171236 3638 1420408 SGTC_173 1273-0061 2.693 µM -0.645092926901457 0.28528537950142 no 2406 0.259433483612569 3544 2847414 YPL266W DIM1 SGTC_582 0987-0078 156 µM -0.646380195002347 0.284877040741644 no 2407 0.259016581657686 3645 1625765 SGTC_509 pifithrin 175 µM -0.646541631099565 0.284825850722628 no 2408 0.25896432250787 3623 4817 A p53 inhibitor. SGTC_635 k038-0028 24.7 µM -0.648324869393557 0.284260693167386 no 2409 0.25838742608549 3593 4035102 SGTC_508 roscovitine 141 µM -0.648827399358316 0.284101524393071 no 2410 0.258224972679356 3618 160355 A CDKinase inhibitor. SGTC_1733 st037357 54.9 µM -0.649399713785024 0.283920304379598 no 2411 0.258040024478291 3564 1272339 YGL099W LSG1 SGTC_2437 5741531 144.16 µM -0.650931828411852 0.283435441721484 no 2412 0.257545247152451 3663 2262990 SGTC_1914 st062367 72.6 µM -0.654456402305977 0.282321542087435 no 2413 0.256408903354631 3585 978205 SGTC_1019 4262-0212 3.4 µM -0.655011890950165 0.28214617882882 no 2414 0.256230049105332 3648 4677213 SGTC_1104 tacrolimus 29.8 µM -0.655587638321913 0.281964475413676 no 2415 0.256044740690922 3642 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2343 7990716 14.84 µM -0.65572541600896 0.281921001722969 no 2416 0.256000406324223 3588 6456862 SGTC_599 1935-0052 86.5 µM -0.656905838094194 0.281548669579423 no 2417 0.255620732060099 3585 9557311 SGTC_2138 5575593 77.673 µM -0.657641919219279 0.281316612876282 no 2418 0.255384125822389 3609 762213 SGTC_1650 st011916 45.8 µM -0.657882660517544 0.281240736891753 no 2419 0.25530676668069 3602 242528 SGTC_1843 st055809 45.5 µM -0.659513304649808 0.280727056590573 no 2420 0.254783102670439 3604 16413835 SGTC_1471 k673-0312 37 µM -0.660665810236737 0.280364271875802 no 2421 0.254413327214282 3613 24099884 SGTC_2683 piperine 63.03 µM -0.661192860405696 0.280198443158968 no 2422 0.254244319660914 3572 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1192 1488-0095 21.4 µM -0.661433614869474 0.280122709061853 no 2423 0.254167137260438 3597 915875 SGTC_332 4112-0506 40.9 µM -0.661557165506909 0.280083847607529 no 2424 0.254127533483831 3616 2790355 SGTC_379 3970-0972 5.9 µM -0.662161087934255 0.279893928256131 no 2425 0.25393399459569 3611 2898042 YBL034C STU1 SGTC_2124 5246320 200 µM -0.663104898334929 0.279597247286812 no 2426 0.25363168685622 3614 579342 SGTC_675 1309-0189 238 µM -0.663144785104061 0.279584712490187 no 2427 0.253618915065905 3581 4246530 SGTC_251 melphalan 456.522 µM -0.663200038701601 0.279567348972272 no 2428 0.253601223357203 3668 460612 A DNA alkylator. SGTC_901 1112-0062 60.1 µM -0.66545361444896 0.278859606216243 no 2429 0.252880201294404 3626 1908457 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.665904593416282 0.27871807957482 no 2430 0.252736042154132 3599 2346 DNA damaging agent; causes G2/M arrest. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.666009846971892 0.278685053839069 no 2431 0.252702403217934 3682 94937 An inhibitor of serotonin biosynthesis. SGTC_698 k064-0052 127 µM -0.6661661541672 0.278636012359807 no 2432 0.252652451938174 3674 5088751 SGTC_3256 9138902 49.47 µM -0.666901928450567 0.278405219189131 no 2433 0.25241738953328 3631 17228773 SGTC_2507 purpurin 79.67 µM -0.667230013141582 0.278302337632228 no 2434 0.252312611437639 3606 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_204 PMA1.184 62.41 µM -0.66804181668009 0.278047850092003 no 2435 0.252053450057403 3654 2252213 YGL008C PMA1 SGTC_2864 9034755 47.6 µM -0.668937945005005 0.277767059970123 no 2436 0.251767531870424 3623 4930451 SGTC_2099 5377090 177.372 µM -0.66930151163894 0.277653180605231 no 2437 0.251651581361764 3606 2243829 SGTC_148 3253-0744 288.01 µM -0.670566027408266 0.277257276163994 no 2438 0.251248515354154 3609 6893655 SGTC_174 3553-0389 74.3 µM -0.67079699891363 0.27718499164143 no 2439 0.251174929782513 3618 738071 SGTC_1444 4112-3581 28 µM -0.671870202290859 0.276849244395879 no 2440 0.250833165829052 3653 2877249 SGTC_1855 st056195 39.6 µM -0.673474652179296 0.276347670639971 no 2441 0.250322684767507 3599 4028379 SGTC_666 0272-0154 136 µM -0.674298722329434 0.276090228027469 no 2442 0.250060708091305 3656 6870312 SGTC_1852 st056254 31.4 µM -0.674490759476595 0.276030251821604 no 2443 0.249999679274407 3589 442583 SGTC_2253 7938677 135.83 µM -0.67457370543807 0.27600434847858 no 2444 0.249973321746335 3667 2301972 SGTC_77 0828-0286 12.516 µM -0.675482659808299 0.275720567730753 no 2445 0.249684582268856 3615 745345 SGTC_3299 9121982 43.1275 µM -0.676785858850888 0.275313951919853 no 2446 0.249270915814752 3650 17594604 YPL160W CDC60 SGTC_1624 st003710 6.25 µM -0.67823716557412 0.274861472120391 no 2447 0.248810665680065 3652 24207033 SGTC_993 3909-8757 62.7 µM -0.678471060052951 0.274788584196607 no 2448 0.248736533524763 3608 4288324 YLR208W SEC13 SGTC_523 1934-0222 13.7 µM -0.679299034226964 0.274530641366729 no 2449 0.248474204126105 3650 1361595 SGTC_1957 st077035 62.4 µM -0.680532430344943 0.274146617125853 no 2450 0.248083697301252 3708 705593 SGTC_2153 5569715 200 µM -0.680812929439172 0.274059319337628 no 2451 0.247994933909293 3658 2054701 SGTC_2214 7179297 48.276 µM -0.681635988534151 0.273803243673777 no 2452 0.24773457630885 3660 769744 SGTC_1278 0874-0585 172 µM -0.68182723171146 0.273743759759565 no 2453 0.247674101416905 3659 766306 SGTC_2894 9048625 32.47 µM -0.683036321068728 0.273367834919677 no 2454 0.247291945904047 3701 4092861 SGTC_294 k038-0071 157 µM -0.68333899311028 0.273273769459464 no 2455 0.247196330051726 3649 24152826 SGTC_877 0771-0151 33.1 µM -0.684012296986322 0.273064575280703 no 2456 0.246983700381469 3663 6166523 SGTC_254 nsc-64875 3.808 µM -0.685001026007695 0.272757523070511 no 2457 0.246671636766278 3661 56993 SGTC_827 3253-0474 693 µM -0.685239497656319 0.27268349076734 no 2458 0.246596401731647 3652 5402065 SGTC_2001 4023502 57.655 µM -0.685517136948415 0.272597311634562 no 2459 0.246508825248303 3645 108941 YCR052W RSC6 SGTC_2366 9070441 60.58 µM -0.686449343874028 0.272308053894855 no 2460 0.246214898741921 3651 6837235 SGTC_3087 9117406 49.47 µM -0.687182498002614 0.272080668123408 no 2461 0.245983866020644 3643 42546093 SGTC_2787 5284540 71.43 µM -0.687779102962004 0.271895702401585 no 2462 0.245795948768407 3663 736958 SGTC_2770 toltrazuril 17.5 µM -0.687899244589485 0.271858462403466 no 2463 0.245758116160347 3643 68591 Kills coccidiodes. SGTC_1475 4092-1048 11.7 µM -0.687975866476616 0.271834713435216 no 2464 0.245733989554823 3658 2881759 SGTC_2832 7992762 51.95 µM -0.691292387493356 0.270807747565745 no 2465 0.244690907381047 3585 2985177 SGTC_3307 9126885 69.2785 µM -0.691744636275541 0.270667858225686 no 2466 0.244548855128202 3658 24824909 SGTC_1426 4048-4480 71.7 µM -0.692455015969222 0.27044819686122 no 2467 0.244325813154171 3641 14224343 SGTC_1936 st074407 74.3 µM -0.69279136451262 0.270344223311213 no 2468 0.244220246137921 3699 809813 SGTC_1905 st060207 84.5 µM -0.693945169011106 0.269987706066947 no 2469 0.24385829773005 3604 1948547 SGTC_460 trequinsin 123 µM -0.695291986956934 0.269571846891165 no 2470 0.243436167463364 3715 5537 A vasodilator. SGTC_799 1310-0557 151 µM -0.695570171105685 0.26948599152816 no 2471 0.243349026021048 3685 5354492 SGTC_1534 6-azauridine 81.6 µM -0.697260313696641 0.268964661289158 no 2472 0.242819949809713 3708 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1546 5-methoxyflavanone 78.7 µM -0.697534997572496 0.268879981964974 no 2473 0.24273402259355 3700 147795 SGTC_2922 7999257 32.47 µM -0.697711595689802 0.268825547510437 no 2474 0.242678787474732 3658 2988377 SGTC_3146 9095609 49.47 µM -0.699637417041503 0.268232293465668 no 2475 0.242076884544585 3716 17173999 SGTC_2293 7624732 200 µM -0.701525809547542 0.267651209800021 no 2476 0.241487466719305 3644 894453 SGTC_2004 4023728 41.89 µM -0.702032691011074 0.267495343666429 no 2477 0.241329388245431 3660 360084 YDR527W RBA50 SGTC_2287 7945887 168.79 µM -0.704340820156776 0.266786172816677 no 2478 0.240610275517539 3702 1245853 SGTC_246 cycloheximide 667 µM -0.704854167991742 0.266628576358269 no 2479 0.240450497365518 3574 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2102 5377816 72.7585 µM -0.705760237382012 0.266350530300877 no 2480 0.240168626732552 3690 1379702 SGTC_2992 9074591 71.4286 µM -0.706066807757418 0.266256486097515 no 2481 0.240073296036976 3678 17741321 SGTC_2156 5649887 115 µM -0.706554301132712 0.266106976177328 no 2482 0.239921748270825 3735 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1940 st075990 51.1 µM -0.706557413385537 0.266106021813419 no 2483 0.239920780927957 3769 1084979 SGTC_1392 3455-1037 33.9 µM -0.707265656772488 0.265888885981487 no 2484 0.239700701768219 3693 981132 SGTC_642 0335-0876 158 µM -0.707279009013362 0.265884793265374 no 2485 0.239696553758569 3706 6812350 SGTC_2622 2-methoxyxanthone 59.94 µM -0.707298925942659 0.265878688406563 no 2486 0.239690366434381 3692 71034 A hepatoprotective. SGTC_3220 9131269 49.47 µM -0.707719422175234 0.265749816138337 no 2487 0.239559756880568 3735 17722206 SGTC_3239 9133757 49.47 µM -0.70900082624507 0.265357291116798 no 2488 0.239161982053037 3691 17036923 SGTC_2185 6113692 200 µM -0.70904901859417 0.265342534379706 no 2489 0.239147029178284 3672 874150 SGTC_87 0100-0052 35.5 µM -0.71012002347805 0.265014694877884 no 2490 0.238814855161889 3755 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1063 disulfiram 1.84 µM -0.710703414371067 0.264836202873818 no 2491 0.238634021701075 3689 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_845 0330-0138 4.51 µM -0.711503606629644 0.264591478605001 no 2492 0.238386108330164 3661 9039800 SGTC_2514 salinomycin 42.74 µM -0.711793802458343 0.264502755915246 no 2493 0.238296235516244 3758 23682228 A polyether potassium ionophore. SGTC_2582 agaric acid 100 µM -0.71273933648966 0.264213779207234 no 2494 0.23800353513511 3605 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1799 st045822 46.1415 µM -0.713070703606202 0.264112543941209 no 2495 0.237901003482698 3695 3674992 SGTC_1488 4013-0813 75.9 µM -0.715400140610014 0.263401440735304 no 2496 0.237180912819609 3673 2910057 SGTC_416 estradiol valerate 100 µM -0.715471911227821 0.263379546974751 no 2497 0.237158745651446 3716 13791 A steroid. SGTC_1648 st011736 69.8 µM -0.715659968907176 0.263322184036753 no 2498 0.237100667306172 3721 2855514 SGTC_3020 9089140 49.47 µM -0.717631384385146 0.262721230504435 no 2499 0.236492300526843 3727 17217859 SGTC_215 1287-0124 461.5 µM -0.71775478115048 0.262683638378835 no 2500 0.236454249628855 3714 5560863 SGTC_2932 9016711 44.54 µM -0.718312481143311 0.262513772567229 no 2501 0.236282318070114 3692 7117328 SGTC_2023 5144124 124 µM -0.719237403120105 0.262232181267442 no 2502 0.235997328630558 3715 2830192 SGTC_3031 9088762 49.47 µM -0.719248324338125 0.262228857241351 no 2503 0.235993964687475 3686 205253 SGTC_2580 diallyl disulphide 81.36 µM -0.720393109176983 0.261880545659401 no 2504 0.235641495751662 3732 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3035 9091303 49.47 µM -0.720732352784237 0.261777373185219 no 2505 0.235537101501941 3748 25237002 SGTC_1699 st031318 29.054 µM -0.723368844777976 0.260976261300492 no 2506 0.234726653392011 3776 5340658 SGTC_851 0394-0702 453 µM -0.724241498734087 0.260711378789091 no 2507 0.234458742728223 3703 762646 SGTC_2224 6650123 117.647 µM -0.724274674856914 0.260701311348445 no 2508 0.23444856077355 3687 2908370 SGTC_2642 cholecalciferol 100 µM -0.725091012120168 0.26045365325137 no 2509 0.234198098970973 3692 9821465 A vitamin D precursor, similar to steriods. SGTC_3259 9138485 49.47 µM -0.725290779047543 0.260393066982193 no 2510 0.234136830714349 3824 17646153 SGTC_3062 9077494 49.47 µM -0.727399716649209 0.259753901439298 no 2511 0.233490564016819 3686 16459633 SGTC_171 k064-0041 9.68 µM -0.727721342224325 0.259656496079715 no 2512 0.233392091512865 3699 53325 SGTC_2624 nerol 100 µM -0.728768635669918 0.259339450536354 no 2513 0.233071600092093 3668 637566 A natural product oil. SGTC_853 0419-0306 21 µM -0.729753644630466 0.259041442911906 no 2514 0.2327703920244 3721 762713 SGTC_1200 1643-0193 18.4 µM -0.730120619834733 0.258930462405829 no 2515 0.232658229196267 3720 5403974 SGTC_1696 st025591 34.7925 µM -0.731199615345132 0.25860429551444 no 2516 0.232328617545759 3717 2787147 SGTC_369 0957-0393 4.5 µM -0.731754148771137 0.258436749773769 no 2517 0.232159319739277 3742 6997992 SGTC_1715 st032160 10.2275 µM -0.732152781755961 0.258316342265544 no 2518 0.232037660418962 3637 5289825 SGTC_1323 1348-1351 11.2 µM -0.732159131107482 0.258314424672543 no 2519 0.232035722939311 3693 6989654 SGTC_411 enrofloxacin 100 µM -0.734808023952874 0.257515065959707 no 2520 0.231228209829553 3779 71188 A bacterial gyrase inhibitor. SGTC_2606 farnesol 9.78 µM -0.734825352602823 0.25750984091128 no 2521 0.23122293236976 3749 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2244 6635614 200 µM -0.734832757822968 0.257507608057426 no 2522 0.231220677122147 3655 836499 SGTC_836 0330-0104 1.35 µM -0.736301010290096 0.257065093008265 no 2523 0.230773765760065 3740 46494820 SGTC_2121 5257820 149.641 µM -0.737326833201104 0.256756156193856 no 2524 0.23046180903434 3798 791256 SGTC_367 0335-0881 7.1 µM -0.738936403240214 0.256271807929735 no 2525 0.229972807982433 3709 23828853 SGTC_82 0054-0107 293.755 µM -0.740380433252876 0.25583767928936 no 2526 0.229534594040408 3730 3104697 SGTC_2438 5259590 200 µM -0.74240078971972 0.255230930515199 no 2527 0.228922270615885 3773 1201127 SGTC_493 zm226600 134 µM -0.743195838138264 0.254992369872624 no 2528 0.228681561358567 3749 5240098 A potassium channel opener. YCR052W RSC6 SGTC_612 0302-0167 22.4 µM -0.743522869944876 0.254894275235713 no 2529 0.228582590313402 3759 235821 SGTC_1336 1486-0901 104 µM -0.743952229811572 0.254765516836829 no 2530 0.228452687821178 3773 5006114 SGTC_3045 9092950 49.47 µM -0.743987112396624 0.254755057583664 no 2531 0.228442135944376 3723 44120432 SGTC_119 0121-0043 24.815 µM -0.745036707001193 0.254440450550367 no 2532 0.228124764850545 3824 1092378 SGTC_3140 9094243 49.47 µM -0.745079728158074 0.254427559670395 no 2533 0.228111761622885 3765 19291112 SGTC_2911 7942208 15.64 µM -0.745191371030717 0.254394108543384 no 2534 0.228078019293549 3742 1243384 SGTC_2227 7312221 64.1025 µM -0.745956809952834 0.254164825097953 no 2535 0.227846752841596 3769 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3222 9128301 49.47 µM -0.748740281961636 0.253331964322059 no 2536 0.227006879790168 3783 4911358 SGTC_413 propylparaben 100 µM -0.74943234889141 0.253125109397239 no 2537 0.226798329758118 3714 7175 A pharmaceutical preservative. SGTC_2178 5812956 200 µM -0.75046178836356 0.252817580152928 no 2538 0.226488314698442 3740 5403383 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.750791622398926 0.252719088919964 no 2539 0.226389036018527 3743 641818 YHR062C RPP1 SGTC_3113 9123498 49.47 µM -0.751004645766363 0.252655489081064 no 2540 0.226324929931037 3780 8897275 SGTC_381 3461-2219 42.7 µM -0.754282804418225 0.251677832472748 no 2541 0.225339712714433 3731 2883159 SGTC_435 c-PAF 6.7 µM -0.754536207431084 0.251602342494956 no 2542 0.225263656268681 3785 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1277 0873-0036 22 µM -0.755186755034172 0.251408596015485 no 2543 0.225068467329998 3815 5965735 SGTC_593 1203-0218 61.7 µM -0.755270021846105 0.251383803137108 no 2544 0.225043491050337 3786 3666956 SGTC_2996 9066192 71.4286 µM -0.756280528649846 0.251083025528765 no 2545 0.224740509902541 3811 6472854 SGTC_1494 4358-1428 177 µM -0.757882134801189 0.250606697333523 no 2546 0.224260773112675 3772 1564571 SGTC_925 2064-1272 59.6 µM -0.758120452633825 0.250535860979876 no 2547 0.2241894383546 3767 6815817 SGTC_1929 genistein trimethyl ether 50.5 µM -0.759643773284055 0.250083327811209 no 2548 0.223733773184182 3741 136420 SGTC_1462 k081-0014 26.5 µM -0.760346422126194 0.249874738013463 no 2549 0.223523770053727 3511 3270634 SGTC_1387 3342-1166 1.8 µM -0.76085644229593 0.24972339022967 no 2550 0.223371408785369 3779 3418228 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.761395870994422 0.249563368493138 no 2551 0.223210326461562 3748 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_31 0508-1974 57.237 µM -0.761432244373072 0.249552580276888 no 2552 0.223199467149848 3722 6810525 SGTC_1735 st034310 56.75 µM -0.761917525743695 0.249408671235939 no 2553 0.223054614645148 3903 871153 SGTC_2945 9067681 61.76 µM -0.76235841276003 0.249277965485921 no 2554 0.222923059914833 3843 16456930 SGTC_998 3996-0085 177 µM -0.765240796072309 0.248424349757806 no 2555 0.222064085467441 3814 715391 SGTC_794 k038-0031 316 µM -0.765792081736923 0.248261264564943 no 2556 0.221900013218224 3786 6624242 SGTC_1985 st071382 65.5 µM -0.766725818633314 0.247985170244207 no 2557 0.221622274789898 3805 6123237 SGTC_3151 9099821 49.47 µM -0.76686673884377 0.247943516134835 no 2558 0.221580375576777 3729 17174189 SGTC_601 0986-0029 62.9 µM -0.767725696784811 0.247689700541433 no 2559 0.221325083147572 3759 24747981 SGTC_987 1497-1013 404 µM -0.768963471300026 0.247324191691489 no 2560 0.220957497979724 3775 1676435 SGTC_1378 2093-0007 380 nM -0.771057624325506 0.246706455567849 no 2561 0.220336388267007 3849 3618014 SGTC_2372 9071633 200 µM -0.771980085222929 0.246434609147212 no 2562 0.220063111311984 3844 21321366 SGTC_455 paf C-16 10 µM -0.772285600235106 0.246344610201717 no 2563 0.219972646060188 3763 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2339 9000433 200 µM -0.77306683670122 0.246114552859904 no 2564 0.21974141324411 3809 2988954 SGTC_1964 st076914 61 µM -0.77311011695206 0.246101811126291 no 2565 0.219728607100817 3831 24208661 SGTC_149 3970-0822 46.1 µM -0.773708198096771 0.245925771887144 no 2566 0.219551685440667 3812 3114250 YBL034C STU1 SGTC_1128 3448-9350 235 µM -0.773728556865123 0.24591978067558 no 2567 0.219545664442228 3853 619386 SGTC_1442 4112-3290 3 µM -0.774919596113519 0.245569416072018 no 2568 0.219193585971704 3794 704353 SGTC_1813 st051246 8.6015 µM -0.776773947818617 0.245024460885235 no 2569 0.2186460748737 3714 5291959 SGTC_2045 5106652 78.05 µM -0.777114387696502 0.244924483454674 no 2570 0.218545643074231 3783 673349 SGTC_402 epigallocatechin gallate 10 µM -0.777491937232086 0.244813633657648 no 2571 0.218434294772559 3774 65064 An antioxidant. SGTC_1816 st051957 91.6 µM -0.778873908231205 0.244408112816304 no 2572 0.218026997579039 3785 674121 SGTC_1205 4161-2785 76 µM -0.779616821284831 0.244190264636637 no 2573 0.217808225860362 3894 3498106 SGTC_75 0159-0059 199.013 µM -0.780188581533552 0.244022675785796 no 2574 0.217639941173896 3837 5377270 SGTC_2874 9043904 71.43 µM -0.781698138255683 0.243580507374926 no 2575 0.217195998034734 3795 4463428 SGTC_2457 5731572 11.68 µM -0.782076485889465 0.243469752384395 no 2576 0.217084812418931 3866 2865357 SGTC_10 0279-0212 42.575 µM -0.782516755319746 0.243340905072436 no 2577 0.216955471158197 3799 39851 YBR002C RER2 SGTC_536 3852-0578 10.6 µM -0.783156625894793 0.24315370908401 no 2578 0.216767571000153 3831 2869208 SGTC_328 k915-0120 63.5 µM -0.784480712480371 0.242766591112299 no 2579 0.21637904747691 3813 6624543 SGTC_2872 9044037 25.97 µM -0.78837004948912 0.241631412589202 no 2580 0.215240142226083 3808 6465195 SGTC_3085 9117376 49.47 µM -0.790032391357012 0.241147106363218 no 2581 0.214754425885982 3917 16480349 SGTC_1954 st077032 68.9 µM -0.794065064960981 0.239974424283963 no 2582 0.213578777043348 3725 698907 SGTC_1301 naphtanilide LB 4.81 µM -0.79496950778433 0.239711844252524 no 2583 0.213315619813848 3867 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1194 1488-0194 225 µM -0.795172987640598 0.239652791099856 no 2584 0.213256441252597 3773 1391452 SGTC_2059 5238311 157 µM -0.796294286443231 0.239327514488048 no 2585 0.212930502862965 3840 703021 SGTC_1224 0823-0416 294 µM -0.797894978308068 0.238863589321759 no 2586 0.212465718886141 3900 3598164 SGTC_3347 9188721 44.724 µM -0.799135699106276 0.238504332457568 no 2587 0.212105865801812 3874 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2352 9027995 87.8 µM -0.799708592062104 0.238338548338142 no 2588 0.211939826841061 3800 2997347 SGTC_3011 9081274 71.4286 µM -0.799768327558045 0.238321265677453 no 2589 0.211922518351967 3832 6625322 SGTC_2564 betulinic acid 100 µM -0.801083237125562 0.237941010227887 no 2590 0.211541729930482 3832 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_404 fumagillin 50 µM -0.804912551065327 0.236835517706312 no 2591 0.210435072553464 3823 12015870 A methionine aminopeptidase binder. SGTC_1140 3229-1848 2.98 µM -0.805163189368993 0.236763259024217 no 2592 0.210362757713879 3865 2849525 SGTC_1668 st014914 51.6 µM -0.80522036235643 0.236746777828151 no 2593 0.210346264053163 3847 2839556 SGTC_2403 6032726 181.2 µM -0.806460886056568 0.236389328802801 no 2594 0.209988576160925 3905 2881040 SGTC_3193 9111931 49.47 µM -0.806642994134248 0.236336880536356 no 2595 0.209936097911111 3861 17087244 SGTC_917 harmaline 728.087 nM -0.806733718882739 0.236310753632027 no 2596 0.209909956554747 3858 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1572 epiandrosterone 68.9 µM -0.807732830148347 0.236023134883177 no 2597 0.209622200001341 3758 441302 A steroid. SGTC_3066 9117245 49.47 µM -0.807940319550971 0.235963428154398 no 2598 0.20956246956171 3910 17176980 SGTC_1698 5-fluorocytosine 1.055 µM -0.80850330035076 0.235801467884788 no 2599 0.209400453457444 3862 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1703 st026983 48.3 µM -0.809339153863031 0.235561119738655 no 2600 0.209160045319427 3832 1104023 SGTC_2085 5307070 144.047 µM -0.809944419089246 0.235387161235582 no 2601 0.208986060456155 3799 2840351 SGTC_458 nppb 133 µM -0.810304427184967 0.235283725409001 no 2602 0.208882615753738 3844 4549 A chloride channel blocker. SGTC_1076 itraconazole 331 nM -0.810493145051068 0.235229513909137 no 2603 0.208828401627953 3839 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3143 9086658 49.47 µM -0.810628463626328 0.235190646250495 no 2604 0.208789532944532 3931 25236626 SGTC_2389 9091542 195.52 µM -0.810813477886974 0.235137510201646 no 2605 0.208736396654295 3848 3626624 YOL127W RPL25 SGTC_2854 9024559 71.43 µM -0.811389475541558 0.234972126281229 no 2606 0.208571020558574 3886 3163529 SGTC_1753 st043925 64 µM -0.811864039924104 0.234835914799268 no 2607 0.208434825275531 3900 670181 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.812179644023556 0.234745352941375 no 2608 0.208344279067377 3885 5377381 SGTC_883 0850-0245 24.6 µM -0.813870906528603 0.234260378242374 no 2609 0.207859454576629 3949 6823229 YPR165W RHO1 SGTC_2247 cerulenin 830 nM -0.816339112947575 0.233553608913691 no 2610 0.207153104966898 3862 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2347 9049783 174.81 µM -0.817106390182749 0.233334140751488 no 2611 0.206933815719628 3884 6467988 YPL169C MEX67 SGTC_3191 9110352 49.47 µM -0.817991963318876 0.233080978141242 no 2612 0.206680888146733 3809 17122424 SGTC_538 2922-0838 53.3 µM -0.819921417327895 0.232529925306169 no 2613 0.206130453226171 3847 777039 SGTC_1235 benzylparaben 21.5 µM -0.822383197034687 0.231827893021181 no 2614 0.205429419740619 3871 7180 SGTC_833 3852-0053 558 µM -0.822473339094308 0.231802209396323 no 2615 0.205403777161805 3929 3123681 SGTC_2591 skatole 100 µM -0.823416397074433 0.231533604721847 no 2616 0.205135620842252 3917 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2589 lobaric acid 100 µM -0.825196973678384 0.231026928806469 no 2617 0.204629885651274 3896 73157 A novel microtubule depolymerizer. SGTC_880 0833-0487 87.2 µM -0.825199136041655 0.231026313866896 no 2618 0.204629271928964 3862 76075 SGTC_424 splitomicin 100 mM -0.825425320242216 0.230961995948789 no 2619 0.204565082339274 3969 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1465 k213-0056 144 µM -0.825764543728056 0.230865552831702 no 2620 0.20446883540607 3758 24048857 YMR208W ERG12 SGTC_3135 9127742 49.47 µM -0.826671553263001 0.230607795476458 no 2621 0.20421162452772 3952 3643468 SGTC_1864 st057645 30.4 µM -0.827640898605214 0.230332501152021 no 2622 0.203936949499839 3901 688666 SGTC_1459 k035-0031 35.7 µM -0.828529846658724 0.230080201296311 no 2623 0.203685249584553 3714 3877128 YMR208W ERG12 SGTC_1899 st063254 59.6 µM -0.829853501938272 0.229704810221295 no 2624 0.203310808539551 3809 3093813 SGTC_2430 5571206 200 µM -0.831991145014094 0.229099295644174 no 2625 0.202706971361604 3905 1731771 SGTC_1307 1187-1599 12.2 µM -0.832017547754373 0.229091822334144 no 2626 0.202699519874276 3878 1538471 SGTC_1562 morin hydrate 59.1 µM -0.832696437462429 0.228899709201563 no 2627 0.202507977116715 3961 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2223 6903751 107.57 µM -0.835050978032294 0.228234119139941 no 2628 0.201844503150136 3834 5598863 SGTC_2200 6600604 21.907 µM -0.835312113679519 0.228160367452099 no 2629 0.20177099933201 3853 2904777 SGTC_1990 st072050 59.8 µM -0.836078518615095 0.227943991601537 no 2630 0.201555366136488 3886 17233948 SGTC_1428 4049-0204 61.7 µM -0.837881483778833 0.227435423595547 no 2631 0.201048634489911 3943 X1428 SGTC_2643 anethole 100 µM -0.840393924764875 0.226727798596732 no 2632 0.200343777162711 3890 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2940 9060638 45.86 µM -0.840428198954866 0.226718153923154 no 2633 0.200334171923672 3907 4027022 SGTC_1587 estradiol valerate 56.1 µM -0.840489617793955 0.226700871390611 no 2634 0.200316960170196 3930 13791 A steroid. SGTC_2304 7443016 91.4 µM -0.842340231659918 0.226180479418964 no 2635 0.199798768823187 3828 939854 SGTC_628 1636-0253 16 µM -0.842413259080945 0.226159957986782 no 2636 0.19977833692784 3903 4456143 SGTC_1153 4055-0057 267 µM -0.842585048471471 0.226111687607096 no 2637 0.199730277981451 3929 882706 SGTC_2988 9073640 71.4286 µM -0.842835676529948 0.226041275126107 no 2638 0.199660175997884 3945 9102229 SGTC_2029 5175081 200 µM -0.84291394725988 0.226019287964284 no 2639 0.199638286297895 3885 1380876 SGTC_3165 9101544 49.47 µM -0.842965267898321 0.226004872054054 no 2640 0.199623934419162 3901 5002184 SGTC_2203 7227154 166.4 µM -0.84300510837827 0.225993681265959 no 2641 0.199612793408739 3876 896304 SGTC_2141 5621638 7.665 µM -0.845049788979377 0.225419771898793 no 2642 0.199041520456353 3940 2856238 SGTC_3295 9122362 53.5725 µM -0.845348206567239 0.225336079875725 no 2643 0.198958226616094 3954 4730473 SGTC_131 0141-0277 33.849 µM -0.845410249948647 0.225318681850485 no 2644 0.19894091180466 3855 1547771 SGTC_656 4090-1979 187 µM -0.846410016358097 0.225038435159014 no 2645 0.198662026350373 3923 22330961 SGTC_2100 5377183 190 µM -0.846421769542611 0.225035141773467 no 2646 0.198658749195067 3918 2844202 SGTC_2394 5221648 200 µM -0.847271741603858 0.224797041663378 no 2647 0.198421836849122 3972 788586 SGTC_1841 st054148 70 µM -0.847395746595214 0.224762316463241 no 2648 0.198387287246544 3943 675442 SGTC_1085 doxorubicin 7.67 µM -0.848239261538109 0.224526187147444 no 2649 0.19815236800184 3905 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2256 7954252 200 µM -0.848590508291603 0.224427902428067 no 2650 0.198054595190594 3926 2972920 SGTC_1218 1348-1416 30.7 µM -0.8487468890353 0.224384152335757 no 2651 0.198011074525503 3849 6787668 SGTC_129 0088-0017 176.636 µM -0.849727283985486 0.2241099810094 no 2652 0.197738362839486 3751 182446 SGTC_693 4161-2696 114 µM -0.852814391009656 0.223247903319364 no 2653 0.196881121034804 3940 805759 SGTC_2927 9011802 47.9 µM -0.852923016458669 0.223217603971106 no 2654 0.196850998466422 3930 43912568 SGTC_410 α-linolenic acid 100 µM -0.853637340515888 0.223018412910987 no 2655 0.196652981116932 3982 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1158 4092-0494 91.8 µM -0.853644460667969 0.223016427948356 no 2656 0.196651007951329 4001 1148199 SGTC_2245 6637752 200 µM -0.85386205648643 0.222955771235841 no 2657 0.196590712693892 3985 681890 SGTC_1608 st001473 40.5 µM -0.854909622791827 0.222663884640089 no 2658 0.196300591478007 3875 7292267 SGTC_1376 2910-0861 41.3 µM -0.855578798034577 0.222477544368463 no 2659 0.196115400777964 3861 1112859 SGTC_618 k072-0232 33.2 µM -0.856047778831422 0.222347003780527 no 2660 0.195985676002457 3962 5872756 YGL099W LSG1 SGTC_168 3970-0862 530.542 µM -0.856596059379412 0.222194445560118 no 2661 0.195834082145087 3902 3135186 SGTC_3203 9113543 49.47 µM -0.857691386651235 0.2218898513666 no 2662 0.195531448721919 4019 17018012 SGTC_2478 5763493 32.33 µM -0.858031457941535 0.22179533114209 no 2663 0.195437546539436 3858 1365576 YLR208W SEC13 SGTC_1229 0139-0193 12.2 µM -0.85831626003803 0.221716190268652 no 2664 0.195358926641596 3955 3090752 SGTC_1046 2001-0062 216 µM -0.858349012004639 0.221707090178989 no 2665 0.195349886661079 3816 739778 SGTC_3306 9127676 59.7925 µM -0.860188845554087 0.221196237725001 no 2666 0.194842476197877 3922 41905287 SGTC_615 k087-0205 167 µM -0.860748106251295 0.221041085660589 no 2667 0.194688395852073 3900 9642773 SGTC_1945 st075991 56.6 µM -0.860812308351568 0.221023278474829 no 2668 0.194670712456275 3945 1084980 SGTC_2627 acetyl isogambogic acid 100 µM -0.866631429234145 0.219412691790588 no 2669 0.193071993630883 3944 6857789 A caspase activator and apoptosis inducer. SGTC_617 3770-0098 35 µM -0.867013202901254 0.219307262657389 no 2670 0.192967387837099 3862 5962639 SGTC_927 2425-1185 123 µM -0.867193801168347 0.219257399487022 no 2671 0.192917916063802 3881 730375 SGTC_2598 perillyl alcohol 100 µM -0.868722940554989 0.21883546545299 no 2672 0.192499345310481 3962 10819 An apoptosis inducer. SGTC_1157 4092-0394 27.6 µM -0.870343669567954 0.218388769592383 no 2673 0.192056310347207 4031 3659885 SGTC_2702 st077768 96.8 µM -0.870505527428578 0.218344188137101 no 2674 0.192012099926574 3915 6484119 SGTC_2198 6589944 200 µM -0.871534216346839 0.218060972911138 no 2675 0.191731265849172 3926 5290268 SGTC_2404 5161160 200 µM -0.871860171351761 0.217971276259513 no 2676 0.191642332000771 3895 2831543 SGTC_2768 sulfasalazine 50.2 µM -0.873398285700052 0.217548303426626 no 2677 0.191223012544856 3896 5384001 An antioxidant and salicylic acid derivative. SGTC_1298 1079-1278 263 µM -0.873752565125131 0.217450945735062 no 2678 0.191126508937289 3955 2840950 SGTC_541 4513-1321 94 µM -0.8742928652303 0.217302517106184 no 2679 0.190979391914114 3934 747515 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.875003841187152 0.217107290415549 no 2680 0.190785907840102 3881 279621 SGTC_1590 st077108 57.8 µM -0.875171976420394 0.217061137029149 no 2681 0.190740169328036 3941 5489485 SGTC_3054 9094397 49.47 µM -0.875991312926458 0.21683630901308 no 2682 0.190517378191344 3958 2598354 SGTC_405 ebelactone b 50 µM -0.877006424850102 0.216557946549192 no 2683 0.190241574188657 3905 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_739 1486-1183 203 µM -0.879692775870388 0.215822297687801 no 2684 0.189512881973412 3924 4346692 SGTC_2090 5301565 104.445 µM -0.886217229741362 0.214041638939077 no 2685 0.187750240432869 3945 2056344 SGTC_2273 7815444 169.05 µM -0.88761662846036 0.213660830740694 no 2686 0.187373502967422 3891 2824616 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.888150821458772 0.2135155688372 no 2687 0.187229814159695 3973 91467 include heat shock SGTC_3159 9100096 49.47 µM -0.888971300165245 0.21329257002365 no 2688 0.187009252114415 3917 25236875 SGTC_1309 pyrazolanthrone 13.4 µM -0.889898113007324 0.213040833949591 no 2689 0.186760298632472 3957 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_681 1642-0006 26.6 µM -0.89091706529877 0.212764271582411 no 2690 0.186486832213012 3967 4446530 SGTC_2952 9073731 13.78 µM -0.891406269860597 0.212631566984207 no 2691 0.186355627652657 4037 16457353 SGTC_364 0083-0097 67.7 µM -0.892028493591661 0.212462848655833 no 2692 0.186188830028967 4054 5207356 SGTC_98 0074-0023 107.663 µM -0.89280616666097 0.212252089648429 no 2693 0.18598049170151 3961 3563821 SGTC_3197 9113331 49.47 µM -0.892839050953868 0.212243180292631 no 2694 0.185971685197983 3979 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1431 4049-0260 9.09 µM -0.893962221713194 0.211939010408516 no 2695 0.185671052241418 3941 3854841 SGTC_2334 9017922 200 µM -0.894163963655441 0.211884402978054 no 2696 0.185617085042926 4040 3163164 SGTC_61 0978-8327 98.565 µM -0.896795987841193 0.211172722234707 no 2697 0.184913894640645 3906 6150059 YHR072W ERG7 SGTC_2014 4013930 200 µM -0.896833326046273 0.211162636334882 no 2698 0.184903931022535 3903 64556 SGTC_323 4013-0906 34.3 µM -0.897028159507155 0.21111001195824 no 2699 0.184851945553666 3972 2910086 SGTC_245 methotrexate 289.6 µM -0.898706104391295 0.210657118499075 no 2700 0.184404612326708 3953 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_571 k831-0106 44.2 µM -0.899336105625277 0.210487222408776 no 2701 0.184236830620265 3858 4783639 SGTC_1225 1216-0074 20.6 µM -0.903535565378263 0.2093567861511 no 2702 0.183120860674707 3982 4241466 SGTC_1819 st053448 58.6 µM -0.905216619969378 0.208905272826025 no 2703 0.182675319353466 3891 2857616 SGTC_1988 st071872 53.4 µM -0.906571083733002 0.208541895971483 no 2704 0.182316829439285 3999 16414116 SGTC_176 1486-1328 72.834 µM -0.908568229071051 0.208006780292142 no 2705 0.181789041693724 4054 22310231 SGTC_1256 0570-0116 285 µM -0.908828555484204 0.207937088126379 no 2706 0.181720315434188 3996 410638 SGTC_870 0573-2213 57.6 µM -0.910259667261978 0.207554210486001 no 2707 0.181342791829788 3965 3916321 SGTC_2319 6033012 152.6 µM -0.910494054503629 0.207491542580693 no 2708 0.181281007913374 3933 847246 SGTC_2413 inermin 26.06 µM -0.910643322524434 0.207451638754254 no 2709 0.181241668091473 4095 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_444 curcumin 90.4 µM -0.911396833990077 0.20725027175892 no 2710 0.181043160586917 3940 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_587 k089-0003 57 µM -0.912003011705179 0.207088361889608 no 2711 0.180883566075968 3873 9659696 SGTC_892 0929-0076 29 µM -0.913093942322556 0.206797163269165 no 2712 0.180596568007568 3968 5751038 SGTC_2865 9030313 51.95 µM -0.913465302086821 0.206698092724362 no 2713 0.180498937215182 3933 42562754 SGTC_1043 0916-0009 19.3 µM -0.9136345839482 0.206652941406908 no 2714 0.180454443859751 4028 3101130 SGTC_2611 pyromycin 23.93 µM -0.916174035513185 0.205976313272447 no 2715 0.179787810711205 3988 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1073 triclabendazole 3.09 µM -0.918270995357899 0.205418577317284 no 2716 0.179238504115304 4063 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2119 5528445 120.635 µM -0.918772954736855 0.205285202537529 no 2717 0.179107170685676 4011 791935 SGTC_1247 0448-0043 5.84 µM -0.919204225943011 0.205170651290958 no 2718 0.17899438058313 4036 3089013 YGL099W LSG1 SGTC_2104 5389443 200 µM -0.919645722130671 0.205053423509392 no 2719 0.178878962653763 4058 2244536 SGTC_1863 st057641 20.1 µM -0.923425884283351 0.204051330951055 no 2720 0.177892653899328 4007 3921635 SGTC_804 1595-0054 20.9 µM -0.923664579572825 0.203988152704494 no 2721 0.177830489569003 3939 761523 Stimulates phospholipase C. SGTC_2863 9028737 58.44 µM -0.923684410392256 0.203982904376287 no 2722 0.177825325569148 3980 6460917 SGTC_2981 9013952 38.96 µM -0.926035510579235 0.203361244019187 no 2723 0.177213763090618 3975 2996344 SGTC_3285 9112818 20.8695 µM -0.926136753036745 0.203334499656912 no 2724 0.177187458014879 3978 17017947 YPR165W RHO1 SGTC_1155 4088-0394 48.2 µM -0.927341344514865 0.203016454001908 no 2725 0.176874667216236 3986 2326248 SGTC_2357 9067248 200 µM -0.928285974374906 0.202767253387906 no 2726 0.176629623767509 4003 9150235 SGTC_589 1227-0070 34.1 µM -0.928705372129926 0.202656671649366 no 2727 0.176520897966715 4055 2841384 SGTC_2649 anisomycin 9.56 µM -0.928730701657035 0.202649994219655 no 2728 0.176514332827813 3991 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1481 3346-2004 36 µM -0.928900528986486 0.202605227334726 no 2729 0.176470319413652 4029 2770522 SGTC_2621 lithochol-11-enic acid 100 µM -0.9292094458772 0.202523811269722 no 2730 0.176390276560149 3921 6708711 SGTC_3250 9135583 49.47 µM -0.929352439131163 0.202486131549219 no 2731 0.176353233634765 4027 7699353 SGTC_1439 4092-1168 46 µM -0.929579596466074 0.202426282624326 no 2732 0.176294397817295 4017 2886240 SGTC_2460 5552655 174.22 µM -0.929690932157587 0.202396952979641 no 2733 0.176265565396105 4026 5401989 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.931309182067747 0.201970937344383 no 2734 0.175846826814097 4042 551469 SGTC_514 4466-0038 2.65 nM -0.931840878762742 0.2018310816933 no 2735 0.175709382526874 3866 5722064 SGTC_2623 humulene 100 µM -0.932301188749847 0.201710050197099 no 2736 0.175590446779746 4024 6187145 An anti-inflammatory. SGTC_1690 st023502 41.2 µM -0.932405280045539 0.201682687004718 no 2737 0.175563558552361 4012 24207482 SGTC_2657 nystatin 74.44 µM -0.933344379067743 0.201435920135202 no 2738 0.175321094207802 4044 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_325 2810-4341 181 µM -0.933612566985422 0.201365481677079 no 2739 0.175251890229092 4015 774970 SGTC_47 0149-0135 24.25 µM -0.935604931049528 0.200842657809319 no 2740 0.174738317386938 4045 5239155 SGTC_1384 3089-0840 101 µM -0.937978201163022 0.200220943183405 no 2741 0.174127806395909 4014 1069836 SGTC_1723 st034307 2.5525 µM -0.939965996216169 0.199701100761087 no 2742 0.173617501472456 4074 867466 SGTC_2722 naftopidil 47.16 µM -0.941940821129722 0.199185455186351 no 2743 0.173111469521455 3927 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1510 1123-0200 71.5 µM -0.942036116017485 0.19916059308476 no 2744 0.173087074806835 4096 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1016 4226-1401 38 µM -0.942137437587106 0.199134160693533 no 2745 0.173061139712738 3987 2901613 SGTC_1931 st074438 57.1 µM -0.942825613637857 0.198954687833276 no 2746 0.172885054076815 3989 2787313 SGTC_389 tpck 16.7 µM -0.943157567245755 0.19886815086111 no 2747 0.172800156961069 4044 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2662 daunorubicin 22.37 µM -0.945827593133674 0.198172927429994 no 2748 0.172118264635546 3923 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2051 5263410 176 µM -0.946320890595195 0.198044643021585 no 2749 0.171992470642576 4041 227584 SGTC_1591 genipin 88.4 µM -0.94692074052839 0.197888716707896 no 2750 0.171839584191872 4077 442424 A DNA cross-linking agent. SGTC_1725 st036284 20.55 µM -0.950860373948338 0.196866483915587 no 2751 0.170837629848697 4133 707914 SGTC_810 3825-7150 143 µM -0.953129068740384 0.196279269832439 no 2752 0.17026233974853 4099 22330411 YGL099W LSG1 SGTC_1889 st059080 5.18 µM -0.954749146680485 0.195860590104766 no 2753 0.169852284835649 3957 176925 Isolated from Daphnopsis sellowiana. SGTC_223 busulfan 5 mM -0.955991610107296 0.195539865471624 no 2754 0.169538236627394 4050 2478 A DNA alkylator. SGTC_2571 chrysanthemic acid 100 µM -0.957132974803612 0.195245519300507 no 2755 0.169250070922188 4071 2743 An insecticide. SGTC_2648 atorvastatin 78.68 µM -0.95803931433727 0.195011975586124 no 2756 0.169021467242269 4055 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3134 9127454 49.47 µM -0.958666450979354 0.19485047576179 no 2757 0.16886340232958 4078 24262820 SGTC_253 dyclonine 31.25 µM -0.958752775851086 0.194828251807081 no 2758 0.168841652255517 4138 3180 An oral anasthetic. SGTC_996 3970-0799 1.8 µM -0.95904767224245 0.194752343670942 no 2759 0.168767364902241 4062 6615648 YGL040C HEM2 SGTC_3169 9102970 49.47 µM -0.959087320002972 0.194742139466886 no 2760 0.168757378836444 4092 17027839 SGTC_3008 9078912 71.4286 µM -0.959227090157485 0.194706169205347 no 2761 0.168722178011625 4026 16648731 SGTC_200 k038-0079 37.545 µM -0.959315425223809 0.194683438000137 no 2762 0.168699933441272 4007 3436683 SGTC_3304 9125678 46.087 µM -0.960687058926843 0.194330683602818 no 2763 0.168354769995536 3987 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1770 st043884 66.3 µM -0.962139248308408 0.193957636470169 no 2764 0.16798983054564 4052 670149 SGTC_2191 5911152 200 µM -0.962858890250519 0.19377293234603 no 2765 0.167809171230341 4046 2875902 SGTC_1628 st004252 77.7 µM -0.962982869347162 0.193741122560553 no 2766 0.167778060084807 4083 692968 SGTC_1485 3909-9022 254 µM -0.963214527629758 0.193681693651925 no 2767 0.167719938024856 4068 714516 SGTC_3174 9107204 49.47 µM -0.963468030770189 0.193616673468737 no 2768 0.167656350044286 4093 3938802 SGTC_2083 5306046 65.942 µM -0.963912135369627 0.193502798637984 no 2769 0.167544989587651 4067 539837 SGTC_1897 st060201 15 µM -0.966760271505665 0.192773466997041 no 2770 0.166831944594159 4098 611878 SGTC_1695 st026914 34.495 µM -0.968785054755192 0.192255996878298 no 2771 0.166326222433562 4015 3289191 SGTC_909 3448-9333 149 µM -0.974611902540412 0.190771587300599 no 2772 0.164876403628431 3978 3344074 SGTC_201 4262-0159 12.803 µM -0.976838008065395 0.190206340957629 no 2773 0.164324678040666 4096 1341029 SGTC_1633 st005664 67.9 µM -0.977188389756404 0.190117466859912 no 2774 0.16423794740472 4058 2063822 SGTC_414 piperonyl butoxide 100 µM -0.977335234967757 0.190080227253296 no 2775 0.164201607363771 4052 5794 A potent inhibitor of cytochrome P450. SGTC_762 1165-0429 115 µM -0.978856398361531 0.189694727519754 no 2776 0.163825469226962 4075 5967793 SGTC_2665 lovastatin 100 µM -0.978879140601978 0.189688967734811 no 2777 0.163819849998222 4085 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1362 1611-0397 101 µM -0.979467356539723 0.189540031338614 no 2778 0.163674555099352 4030 27816 SGTC_1233 0325-0408 14.2 µM -0.979999948183496 0.189405241110017 no 2779 0.163543072116498 4111 12874 SGTC_71 0417-1750 47.813 µM -0.981418368294394 0.189046550075392 no 2780 0.163193235872639 4089 6811472 SGTC_1919 st067113 52.3 µM -0.981560512526669 0.189010627625829 no 2781 0.163158204536882 4109 1268243 SGTC_2370 9071495 200 µM -0.985916614547416 0.187911800590099 no 2782 0.162087016565601 4079 21791103 SGTC_3273 9137859 49.47 µM -0.98658657305893 0.187743154157094 no 2783 0.161922677601269 4140 2377234 SGTC_406 estrone 100 µM -0.987935875607287 0.187403782566461 no 2784 0.161592027007651 4078 5870 A steroid. SGTC_1741 st038134 10.228 µM -0.988422217257202 0.187281552740829 no 2785 0.161472955536236 4151 1272587 SGTC_2502 avocadyne acetate 18.59 µM -0.989759867998553 0.186945621945148 no 2786 0.161145752430642 4006 3952079 SGTC_2333 9017922 200 µM -0.989838944221293 0.186925774823637 no 2787 0.161126423127021 4133 3163164 SGTC_3063 1327-0034 4 µM -0.990854843681111 0.186670913020117 no 2788 0.160878232366246 3977 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2987 9018338 71.43 µM -0.992691303011375 0.186210741122292 no 2789 0.160430207260813 4113 5055682 SGTC_979 1426-2828 121 µM -0.996594317170656 0.185235078248534 no 2790 0.159480732740402 4184 747872 SGTC_260 nsc-65238 3.989 µM -0.997161018183149 0.185093680557271 no 2791 0.159343179537237 4070 3246252 SGTC_753 1322-0200 289 µM -0.99756880016837 0.184991976279385 no 2792 0.15924424822759 4168 5403907 SGTC_985 1493-0307 8.71 µM -1.00181151260136 0.183935868840049 no 2793 0.158217317937506 4110 3278274 SGTC_2592 piperlongumine 83.33 µM -1.00294184451309 0.183655138192631 no 2794 0.157944460743358 4113 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2957 9076800 11.52 µM -1.00882968822085 0.182197147005268 no 2795 0.156528160182508 4071 16459615 SGTC_2838 9002687 71.43 µM -1.01040607094655 0.181808022600058 no 2796 0.156150390227924 4081 6457060 SGTC_3274 9138298 49.47 µM -1.0106377032292 0.181750888842025 no 2797 0.156094931708122 4058 17015756 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.01193547367885 0.181430992285976 no 2798 0.155784453343822 4030 5355888 SGTC_327 1273-0057 3.96 µM -1.01244044423913 0.181306613863657 no 2799 0.155663754401401 3971 3108138 SGTC_1446 4239-0190 62 µM -1.01285265101145 0.181205123520713 no 2800 0.155565273754591 4113 1340085 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.01320777171961 0.181117717002262 no 2801 0.155480464546997 4056 2333 A French combination drug. SGTC_931 2812-0076 566 µM -1.01346492989867 0.181054438673656 no 2802 0.155419069598163 4062 3450959 SGTC_117 lucigenin 22.078 µM -1.01612852417873 0.180399829049115 no 2803 0.154784093727134 4122 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2644 guaiazulene 100 µM -1.01717236883063 0.180143697441741 no 2804 0.154535719060261 4109 3515 A coloring agent. SGTC_2172 5754775 163.918 µM -1.01737096725613 0.180094992550242 no 2805 0.154488493963274 4075 2263357 SGTC_1559 coumarin 343 70.1 µM -1.01758254904152 0.180043112675603 no 2806 0.15443819202523 4136 108770 A hepatotoxic, DNA x-linker. SGTC_3266 9136860 49.47 µM -1.01773980593554 0.18000455934914 no 2807 0.15440081242652 3949 4871271 YPR165W RHO1 SGTC_3080 9117754 49.47 µM -1.02169224202565 0.179037277353402 no 2808 0.15346329203609 4141 9550191 SGTC_3332 9141069 11.198 µM -1.02457837293674 0.178333022820942 no 2809 0.152781086726239 4046 17332883 SGTC_3229 9132204 49.47 µM -1.02569718686351 0.178060487393642 no 2810 0.152517170389992 4163 17682924 SGTC_3156 9099931 49.47 µM -1.02632694311913 0.177907198636909 no 2811 0.152368750709829 4149 18111053 SGTC_1522 st012842 45.6 µM -1.02689044367554 0.177770107731455 no 2812 0.152236027333677 3965 3491067 YOR116C RPO31 SGTC_640 3381-0960 37.1 µM -1.0270622345027 0.177728326958715 no 2813 0.152195580074539 4174 1745025 SGTC_2595 hexamethylquercetagetin 100 µM -1.02728607838669 0.17767389580196 no 2814 0.152142887899912 4094 386331 SGTC_2009 4012297 12.05 µM -1.02841728503441 0.177398986050361 no 2815 0.151876790581163 4132 45595307 SGTC_943 3253-1379 105 µM -1.02849661866978 0.177379716198378 no 2816 0.151858140289065 4153 668464 SGTC_488 nitrendipine 139 µM -1.02851721703902 0.177374713145397 no 2817 0.151853298132773 4158 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2464 5717415 7.67 µM -1.0287617305697 0.177315331068068 no 2818 0.151795827014483 4111 5285744 SGTC_2126 5251174 33.877 µM -1.03073671827909 0.176836149706934 no 2819 0.151332150473941 4144 790722 SGTC_3180 9109287 49.47 µM -1.03129708736931 0.17670033936918 no 2820 0.151200761893298 4167 18891271 SGTC_2480 5767542 37.17 µM -1.03256272951785 0.17639384270222 no 2821 0.150904288729964 4078 2867358 SGTC_1137 ixabepilone 100 µM -1.035400413666 0.175707872769009 no 2822 0.150240976308912 4084 154225 A novel microtubule stabilizer. SGTC_282 k297-0036 65.7 µM -1.03561640353058 0.175655729586796 no 2823 0.150190568095913 4131 5061378 SGTC_469 w7 172 µM -1.03601783274294 0.175558844621969 no 2824 0.150096911568545 4199 45115570 A P450 inhibitor. SGTC_86 0417-1630 471.922 µM -1.03694934027003 0.175334155724318 no 2825 0.149879733713237 4129 3634867 SGTC_2258 7960471 200 µM -1.03976540155451 0.174656003076033 no 2826 0.149224453495322 4178 2974708 SGTC_2761 levamisole 97.89 µM -1.04049502888944 0.174480569136633 no 2827 0.149054986203432 4116 26879 An alkaline phosphatase inhibitor. SGTC_2680 butyl paraben 22.24 µM -1.04266434089448 0.173959634154544 no 2828 0.148551889345861 4205 7184 An antifungal and steroid mimetic. SGTC_1514 1189-1591 158 µM -1.04337054764038 0.17379026043361 no 2829 0.148388354382618 4153 767698 YMR146C TIF34 SGTC_701 4424-0219 185 µM -1.04576713141164 0.173216255945418 no 2830 0.147834279950344 4193 2911779 SGTC_2537 larixol 68.93 µM -1.04779669386578 0.17273110177969 no 2831 0.147366143035656 4134 6708759 SGTC_903 1134-0042 114 µM -1.04917886138374 0.172401199610592 no 2832 0.147047902857182 4158 701009 SGTC_1552 6-methylflavone 10.6 µM -1.05515247375959 0.17098001617857 no 2833 0.145677798154205 4054 689013 SGTC_285 1486-1325 46 µM -1.0558865305701 0.170805895090426 no 2834 0.145510029296718 4199 22310230 SGTC_2251 lansoprazole 556 µM -1.05695433941321 0.170552809414619 no 2835 0.145266213399179 4073 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3077 9117319 49.47 µM -1.05776397500993 0.170361074549953 no 2836 0.14508153026983 4132 17154678 SGTC_3091 9116372 49.47 µM -1.06264561851021 0.169207949430911 no 2837 0.143971345533696 4224 17169793 SGTC_1550 gossypolone 36.6 µM -1.06324048374728 0.169067775724615 no 2838 0.143836453812512 4177 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2240 6690706 185.951 µM -1.06961473429595 0.167570433972576 no 2839 0.142396380102651 4026 805876 SGTC_1321 1326-2144 215 µM -1.07071842470995 0.167312042081844 no 2840 0.142148027881377 4168 3513030 SGTC_2710 st078562 53.7235 µM -1.07080931521686 0.167290774585082 no 2841 0.142127588788276 4101 17250908 SGTC_1836 st055642 81 µM -1.07147559268351 0.167134925327 no 2842 0.141977819715716 4174 8571 SGTC_1560 lithocholic acid 53.1 µM -1.07393646464305 0.166560113326549 no 2843 0.14142557934037 4070 9903 A bile acid which acts as a detergent. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.07563076727309 0.166165099668784 no 2844 0.141046210819877 4191 7104 SGTC_2000 st075254 36.4 µM -1.08589401585534 0.163785250537507 no 2845 0.138762942371586 4088 17234175 SGTC_1182 1222-0449 220 µM -1.08769381244424 0.163370203708762 no 2846 0.138365150108629 4174 658318 SGTC_2481 5478948 45.16 µM -1.09023279274496 0.162785858273827 no 2847 0.137805305756476 4218 77792 SGTC_1694 st024011 44.9 µM -1.0928619923967 0.162182183296381 no 2848 0.137227199069741 4220 2787533 SGTC_624 k048-0052 28 µM -1.09762003842934 0.161093427268236 no 2849 0.13618521953713 4170 6835531 SGTC_2492 derrusnin 100 µM -1.09827439131662 0.160944069422518 no 2850 0.136042345380954 4190 1715307 Part of coumarin class of compounds. SGTC_1319 1306-0155 43.7 µM -1.09903534996807 0.160770492231488 no 2851 0.135876323559993 4245 3122360 SGTC_475 α-linolenic acid 10 µM -1.099784311012 0.160599771138055 no 2852 0.135713054836231 4208 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1999 st074831 12.5 µM -1.10189173195777 0.16012003300465 no 2853 0.135254371758331 4166 17112523 SGTC_340 k038-0059 454 µM -1.1046682403105 0.159489414107227 no 2854 0.13465168499274 4169 23733424 SGTC_533 1222-0222 6.71 µM -1.10472712785676 0.159476056809724 no 2855 0.134638922474536 4226 3982874 SGTC_192 3455-0609 60.9 µM -1.10600877908923 0.159185524862318 no 2856 0.134361359768153 4259 3769639 SGTC_2259 7964009 200 µM -1.10769273780036 0.158804322908972 no 2857 0.133997268392252 4236 313134 SGTC_1871 st057448 67.3 µM -1.10787369764296 0.158763394211088 no 2858 0.133958183156988 4252 691747 SGTC_2805 7950783 58.44 µM -1.1104992343668 0.158170339983835 no 2859 0.133391978926081 4223 1178958 YDL195W SEC31 SGTC_676 falcarinol 140 µM -1.11102645183773 0.158051428020475 no 2860 0.133278481796744 4241 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3326 9140064 16.379 µM -1.11146349785925 0.15795289839594 no 2861 0.133184446776042 4108 1868434 SGTC_3241 9133421 49.47 µM -1.11228225314322 0.157768423084804 no 2862 0.133008405926391 4262 17018221 SGTC_1932 st074806 40.9 µM -1.11230722284956 0.157762799337323 no 2863 0.133003039699585 4277 17251235 SGTC_27 0485-0001 32.618 µM -1.11394732627937 0.157393698989965 no 2864 0.132650892272561 4157 2054479 SGTC_2909 7941780 10.49 µM -1.11410501222134 0.157358242176279 no 2865 0.132617069319388 4188 1243215 SGTC_2774 tamoxifen 10.92 µM -1.11466560924493 0.157232230437271 no 2866 0.132496871787445 4190 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_783 0848-0141 92.7 µM -1.11760428711805 0.156572756340857 no 2867 0.131868018488727 4132 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_626 0214-0009 33 µM -1.1184680523133 0.156379263998562 no 2868 0.131683571886405 4270 3437874 SGTC_2601 securinine 100 µM -1.1185905515351 0.156351835661582 no 2869 0.131657428081806 4186 442872 A GABA receptor antagonist. SGTC_1173 0443-0020 122 µM -1.12145659753915 0.155711014494158 no 2870 0.131046778175587 4201 5331295 SGTC_1706 st031321 9.9705 µM -1.12242081519804 0.155495814340499 no 2871 0.130841779134244 4235 6103185 SGTC_2674 ligustilide 100 µM -1.12288883882477 0.155391428657522 no 2872 0.130742354161399 4270 5319022 A signalling regulator. SGTC_1217 1183-1422 255 µM -1.12489742818831 0.154943967956797 no 2873 0.130316250962127 4247 2849664 SGTC_346 4513-0042 7.16 µM -1.12555841218977 0.154796904448117 no 2874 0.130176239796841 4186 2827372 SGTC_472 calcifediol 10 µM -1.12637138748191 0.15461615062544 no 2875 0.130004176276242 4275 5283731 A vitamin D metabolite. SGTC_63 0099-0242 26.702 µM -1.127711320697 0.154318539513685 no 2876 0.129720927541684 4243 3898502 YLR359W ADE13 SGTC_1822 st052468 42 µM -1.12821677955249 0.154206371059334 no 2877 0.1296141896027 4212 2873678 SGTC_257 daunorubicin 18.5 µM -1.12871148031727 0.154096642204808 no 2878 0.129509782376713 4246 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_774 k060-0086 136 µM -1.12912274658365 0.154005459163954 no 2879 0.129423028474595 4234 5911235 SGTC_663 1486-0733 13.9 µM -1.12922178313446 0.153983506816615 no 2880 0.12940214338585 4238 722445 YPR165W RHO1 SGTC_2735 sertaconazole 140 nM -1.13066405760824 0.153664048274367 no 2881 0.129098257385784 4339 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3172 9105863 49.47 µM -1.13140198765553 0.153500769268009 no 2882 0.12894296764657 4282 2348785 SGTC_715 0868-0130 184 µM -1.13162940205929 0.153450473308918 no 2883 0.128895136764279 4282 2876258 SGTC_980 1473-0395 201 µM -1.13458507259553 0.152797777287831 no 2884 0.128274605254628 4104 768876 SGTC_781 4335-2806 94.4 µM -1.13523967221622 0.152653472502217 no 2885 0.12813745566736 4284 845254 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.14003987708915 0.151598042774455 no 2886 0.127134844043294 4275 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3070 9117005 49.47 µM -1.14348742268988 0.150843024646831 no 2887 0.126418136879968 4317 8779016 SGTC_668 1682-0499 62.6 µM -1.14448053110457 0.150625997478017 no 2888 0.126212203720651 4210 682214 SGTC_2600 tangeritin 87.95 µM -1.14493721375087 0.150526266988706 no 2889 0.12611758352011 4171 68077 A bioactive flavone. SGTC_2727 riluzole 51.77 µM -1.14556489250128 0.150389266107313 no 2890 0.125987615297876 4279 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1303 1160-0052 261 µM -1.14568468418604 0.150363129108482 no 2891 0.125962821645619 4185 3562476 SGTC_1838 st055369 84.5 µM -1.14851633453636 0.149746180945063 no 2892 0.125377736861792 4235 676036 SGTC_984 1492-0255 2.91 µM -1.15065777779866 0.149280735204357 no 2893 0.124936526562593 4209 1585198 SGTC_1328 1441-0025 69.2 µM -1.15156628443862 0.149083562139927 no 2894 0.124749671318674 4221 4562601 SGTC_863 0466-0191 129 µM -1.15158976212483 0.149078469087903 no 2895 0.124744845183667 4289 765160 YPR165W RHO1 SGTC_1061 3448-9325 110 µM -1.15435691170292 0.148479000937308 no 2896 0.124176936379242 4189 723482 SGTC_2852 9023854 51.95 µM -1.15500526946618 0.148338775803948 no 2897 0.124044134297864 4288 19798528 SGTC_1420 4'-methoxyflavone 42 µM -1.15708494310806 0.147889587321053 no 2898 0.12361882883752 4239 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3112 9123419 49.47 µM -1.15819093906388 0.14765107466767 no 2899 0.123393062579321 4303 17015854 SGTC_3245 9134821 49.47 µM -1.15830957876013 0.14762550483042 no 2900 0.123368861898316 4263 17014901 SGTC_957 1187-1561 14.1 µM -1.15914738324664 0.147445021330828 no 2901 0.123198057267401 4200 1538454 SGTC_3255 9139072 49.47 µM -1.16004249311195 0.147252356284531 no 2902 0.123015752882747 4272 17646060 SGTC_2052 5265182 7.135 µM -1.16146283377514 0.146946986089739 no 2903 0.122726864571072 4254 1239884 SGTC_306 1672-3436 11.6 µM -1.1631941702814 0.146575327239222 no 2904 0.122375365638831 4286 6797378 SGTC_2926 9010726 65.15 µM -1.16363566667232 0.146480654072574 no 2905 0.122285845449513 4274 2994293 SGTC_1719 st032227 49.2 µM -1.16377836421913 0.146450063216705 no 2906 0.122256921157639 4254 3125804 SGTC_707 0865-0008 204 µM -1.16673652702322 0.145816871585796 no 2907 0.121658393449259 4281 723043 SGTC_78 0336-0123 156.75 µM -1.16813419913522 0.145518342355544 no 2908 0.121376318676516 4091 6765896 SGTC_3301 9125354 19.7965 µM -1.16866417475739 0.145405252242268 no 2909 0.121269480625005 4244 41905162 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.17110002692662 0.144886232528914 no 2910 0.120779286525497 4274 5106787 A p450 inhibitor. SGTC_2681 menadione 3.18 µM -1.17305733032245 0.144470084625222 no 2911 0.120386408066861 4268 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_32 0928-0142 34.1 µM -1.17329813307309 0.144418942555152 no 2912 0.120338135346324 4243 2244242 SGTC_124 0136-0217 7.121 µM -1.17421031868714 0.14422532178171 no 2913 0.120155396971884 4304 3976905 SGTC_2091 4-phenylthiadiazole 200 µM -1.17893048002606 0.143226215478959 no 2914 0.119212929759104 4276 270010 SGTC_412 gemfibrozil 100 µM -1.1848703131762 0.141975601175243 no 2915 0.118034363317068 4204 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_9 0092-0002 10.449 µM -1.18581360626361 0.141777675931564 no 2916 0.117847958501109 4270 759368 SGTC_1425 4048-4433 7.33 µM -1.18721204134406 0.14148459513292 no 2917 0.117571996204411 4329 23734946 SGTC_1938 st074717 56.4 µM -1.1900632607138 0.140888315750483 no 2918 0.117010764464013 4164 17250979 SGTC_3051 9093778 49.47 µM -1.19230558835623 0.140420573941621 no 2919 0.116570722049298 4345 17217378 SGTC_1184 1269-1718 139 µM -1.19313784532108 0.140247236609356 no 2920 0.11640769597106 4323 5403821 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.19420938329114 0.140024277402827 no 2921 0.116198036763994 4344 279621 SGTC_1149 3909-7961 23.3 µM -1.19423845927367 0.140018230804618 no 2922 0.116192351437419 4323 735261 SGTC_2729 fluphenazine 10.66 µM -1.19706847575557 0.139430553699998 no 2923 0.115639932989137 4213 3372 An atypical antipsychotic. SGTC_720 r052-1644 49.9 µM -1.19891129062618 0.139048780708589 no 2924 0.115281220518241 4303 1422863 YOR257W CDC31 SGTC_898 1000-0849 28.3 µM -1.20208647941066 0.138392652593762 no 2925 0.114665012107829 4292 6751807 SGTC_744 1594-0068 283 µM -1.20413094388888 0.137971298401752 no 2926 0.114269485752081 4265 668392 SGTC_2962 9082311 13.18 µM -1.20657673427142 0.137468383527202 no 2927 0.113797595587903 4264 16459453 SGTC_1986 st071812 45 µM -1.21028145136988 0.13670898851855 no 2928 0.113085456335174 4239 11838594 SGTC_3209 9113616 49.47 µM -1.21491808964299 0.135762615697416 no 2929 0.112198666815995 4347 16649353 SGTC_947 3447-0010 211 µM -1.21525220780715 0.135694593400773 no 2930 0.112134956899527 4262 748350 SGTC_3178 9107506 49.47 µM -1.21618364458223 0.13550508774519 no 2931 0.111957486335362 4280 8897194 SGTC_2521 angolensin 13.4 µM -1.21776565051444 0.135183636156972 no 2932 0.111656520495732 4349 821428 A flavenoid. SGTC_1564 D-Arginine 115 µM -1.21846469168336 0.135041762989129 no 2933 0.111523717229881 4315 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_261 5-fluorouridine 15.376 µM -1.22197078089469 0.134331729017126 no 2934 0.110859338365441 4325 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3225 9130819 49.47 µM -1.22339130290715 0.134044783751384 no 2935 0.110590968334478 4261 4547121 SGTC_2791 5663188 71.43 µM -1.22670528453499 0.133376998054486 no 2936 0.109966690392442 4339 54690634 SGTC_1879 gemcitabine 100 µM -1.231772256724 0.132360406004974 no 2937 0.109017084780881 4280 60750 A nucleoside analog which inhibits DNA replication. SGTC_2202 7226349 200 µM -1.23227680768025 0.132259470550545 no 2938 0.108922850117864 4291 844334 SGTC_1755 st041960 45.185 µM -1.23401077363563 0.131912995102698 no 2939 0.108599444845032 4336 2257073 SGTC_2026 5148700 152 µM -1.23586102215371 0.13154397546621 no 2940 0.108255113829594 4287 79838 SGTC_3247 9135149 49.47 µM -1.23672439154105 0.131372026289857 no 2941 0.108094710046384 4348 8934436 YOR116C RPO31 SGTC_2903 5923464 63.88 µM -1.23688219397738 0.131340615042321 no 2942 0.108065410731805 4325 2876576 SGTC_209 4077-0173 175.592 µM -1.23725950092252 0.13126553151174 no 2943 0.107995379006124 4302 15993494 SGTC_2142 5622915 118.518 µM -1.23818545447106 0.131081393762382 no 2944 0.107823651820115 4327 5322196 SGTC_647 0140-0236 81 µM -1.23859356078559 0.131000293265527 no 2945 0.10774802697264 4332 990837 SGTC_2556 citropten 84.59 µM -1.23864348286215 0.130990374933885 no 2946 0.107738778699315 4340 2775 A potential DNA crosslinker. SGTC_216 k038-0035 28.382 µM -1.24027175758086 0.130667159818709 no 2947 0.107437447434142 4237 4444231 YPR107C YTH1 SGTC_2078 5212016 200 µM -1.24207206933637 0.130310437391032 no 2948 0.107104986352084 4211 1899708 SGTC_2150 5556613 200 µM -1.24272219057984 0.130181784968185 no 2949 0.106985111891184 4345 743190 SGTC_745 0469-0705 296 µM -1.24431477681777 0.129866999699289 no 2950 0.106691867326266 4364 3486736 SGTC_689 0833-0039 98 µM -1.2457889867601 0.129576082348643 no 2951 0.10642093693871 4272 5374726 SGTC_2468 5987765 72.9 µM -1.24609977495605 0.129514809751997 no 2952 0.106363883724947 4366 26772094 SGTC_392 N-ethylmaleimide 8.33 µM -1.24610820849314 0.129513147340855 no 2953 0.106362335838906 4278 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_841 0251-0215 91.2 µM -1.25225819731456 0.128304801437001 no 2954 0.10523789792694 4353 3888614 SGTC_1881 5652484 16 µM -1.25496120886968 0.127776199500708 no 2955 0.104746421086589 4310 2255129 SGTC_1109 tnp00067 928.257 nM -1.25569718682183 0.127632533918507 no 2956 0.10461288978165 4335 676295 SGTC_3243 9134147 49.47 µM -1.25833870752652 0.127117824417451 no 2957 0.104134644075275 4423 24282180 SGTC_2484 5809818 12.04 µM -1.25949186633475 0.126893580921926 no 2958 0.103926363124128 4291 2870548 SGTC_226 1,3-diallylurea 8.28947 mM -1.26007369622249 0.126780542746901 no 2959 0.103821389065078 4255 74537 YKL182W FAS1 SGTC_2565 isoliquiritigenin 100 µM -1.26506263154657 0.12581416783947 no 2960 0.102924438541626 4394 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1087 pterostilbene 9.05 µM -1.26686556351415 0.125466200501198 no 2961 0.10260168193804 4340 5281727 Similar to reservatol, lowers cholesterol. SGTC_3196 9111891 49.47 µM -1.26697148320546 0.125445778824256 no 2962 0.102582743353096 4329 18891510 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.26736860300265 0.125369233431482 no 2963 0.102511760417599 4373 23847180 SGTC_2797 7859098 81.82 µM -1.26800975227774 0.125245719841714 no 2964 0.102397233960817 4320 972681 SGTC_2943 9068529 45.32 µM -1.26982301049588 0.124896866456394 no 2965 0.102073841127842 4329 3270634 SGTC_521 r062-0005 13.8 µM -1.27053633050219 0.124759816804408 no 2966 0.101946825082651 4266 2832033 SGTC_1412 3909-8563 178 µM -1.27746809008211 0.1234334943735 no 2967 0.100718519570811 4439 23767530 SGTC_2883 9059145 45.46 µM -1.27753325125949 0.12342107347875 no 2968 0.100707024465291 4325 16476510 SGTC_2442 5158906 48.48 µM -1.28201273692171 0.122569301001279 no 2969 0.0999190891075777 4358 1893835 SGTC_1688 st021091 57.6 µM -1.28282854654014 0.122414620141641 no 2970 0.099776075304517 4373 3656366 SGTC_1375 2910-0797 186 µM -1.28481940202182 0.122037720979821 no 2971 0.0994277003723784 4347 742508 SGTC_2044 5102272 200 µM -1.2866481807492 0.121692224195628 no 2972 0.0991084711125146 4346 592666 SGTC_2487 5918373 44.05 µM -1.28893438474661 0.121261277142158 no 2973 0.0987104494252934 4414 2876279 SGTC_2841 9004761 38.96 µM -1.29052933184587 0.120961267541634 no 2974 0.098433467223125 4312 2991039 SGTC_2317 5986382 200 µM -1.29173681298143 0.120734487935149 no 2975 0.098224152082819 4380 877883 SGTC_1768 st044301 37.178 µM -1.29315618384936 0.120468295742095 no 2976 0.0979785232592728 4364 3931349 SGTC_1370 2001-0092 44.6 µM -1.29384540573032 0.120339186617543 no 2977 0.0978594126466095 4374 790957 SGTC_3160 9100216 49.47 µM -1.29481975480253 0.120156832122458 no 2978 0.0976912077751991 4345 17191039 SGTC_580 1123-0028 41 µM -1.29582530571124 0.119968842300428 no 2979 0.0975178388040022 4416 1677248 YPR107C YTH1 SGTC_2728 chlorpromazine 9.18 µM -1.29674095477372 0.119797840244534 no 2980 0.0973601663689046 4437 2726 A thorazine and dopamine antagonist. SGTC_2024 5144227 134 µM -1.30057112516363 0.119084400010396 no 2981 0.0967026480002577 4354 3475211 SGTC_250 brefeldin a 552.239 µM -1.31363751653646 0.116673131785347 no 2982 0.0944841086174253 4266 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.31418338773429 0.116573155734745 no 2983 0.0943922487547291 4420 1609 A potent and irreversible inhibitor of serine proteases. SGTC_193 1273-0060 1.558 µM -1.31475507440288 0.11646851674165 no 2984 0.0942961152541846 4208 2847393 YHR072W ERG7 SGTC_1460 k062-0059 9.15 µM -1.31522389919223 0.116382754865539 no 2985 0.0942173326736325 4266 1373085 SGTC_1419 3993-2473 62.6 µM -1.31795194356873 0.115884603904695 no 2986 0.093759867800041 4444 704026 SGTC_2663 amphotericin b 100 µM -1.31858733428278 0.115768796918148 no 2987 0.0936535551622616 4404 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1798 st045719 60.953 µM -1.32001713094164 0.115508501292669 no 2988 0.0934146492370866 4327 3980186 SGTC_3014 9081533 49.47 µM -1.32097256655886 0.115334795420057 no 2989 0.0932552558064457 4416 21367265 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.32534038997124 0.114543054660107 no 2990 0.0925291391980008 4389 616764 SGTC_17 0960-0276 49.807 µM -1.32969138029906 0.113758218929878 no 2991 0.0918099880069864 4374 6821114 SGTC_1056 3448-1962 115 µM -1.33317528006451 0.113132558786579 no 2992 0.0912371447857798 4355 715507 SGTC_1249 0481-0015 10.2 µM -1.33380785047811 0.113019221789976 no 2993 0.0911334187509645 4316 4227577 SGTC_2990 9074105 71.4286 µM -1.33507986538118 0.112791561533076 no 2994 0.090925104288972 4301 6502001 SGTC_726 3448-4391 34.2 µM -1.33607205204711 0.112614211279138 no 2995 0.0907628619415563 4488 1356692 SGTC_93 0109-0045 59.227 µM -1.33770987087012 0.112321892189181 no 2996 0.0904955159994691 4513 88733 SGTC_3249 9135183 49.47 µM -1.33901629997571 0.112089108824657 no 2997 0.0902826832870357 4356 4902779 SGTC_2465 5809242 33.21 µM -1.33904882210867 0.112083318338559 no 2998 0.0902773897945206 4452 2731748 SGTC_2705 st078069 42.8 µM -1.33937389496289 0.112025451664136 no 2999 0.0902244917029041 4427 1530061 SGTC_1983 st071813 46.9 µM -1.34012367425605 0.111892063856852 no 3000 0.0901025702547315 4449 11838595 SGTC_2752 diclazuril 33.15 µM -1.34199852406986 0.111559020078967 no 3001 0.0897982371064749 4321 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2731 amoxapine 43.43 µM -1.34391323494723 0.111219628185214 no 3002 0.0894882228594016 4557 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_764 1951-2361 146 µM -1.3446183837453 0.111094823549061 no 3003 0.0893742517440632 4399 5438930 SGTC_1636 st007707 68.9 µM -1.34596686759241 0.110856434073357 no 3004 0.0891566010258374 4408 403051 SGTC_2419 paclitaxel 166.5 µM -1.35182477191059 0.109825108296802 no 3005 0.088215688792198 4350 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_113 0099-0221 2.5 µM -1.35195379635923 0.10980247039502 no 3006 0.0881950481705277 4370 89219 SGTC_3212 9128307 49.47 µM -1.35232834820966 0.109736772614993 no 3007 0.0881351498193945 4316 27243542 SGTC_1875 nocodazole 6 µM -1.35418402098587 0.109411696951621 no 3008 0.0878388377974325 4439 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1282 0886-0010 32.4 µM -1.35475890147378 0.109311130196419 no 3009 0.0877471923608975 4425 2836211 YNL267W PIK1 SGTC_85 0868-0259 160.055 µM -1.35523618791868 0.109227686527616 no 3010 0.0876711592339868 4332 83173 SGTC_2653 dihydrofissinolide 100 µM -1.35907788984592 0.108557710704419 no 3011 0.0870609541352942 4455 6857746 SGTC_1051 3253-3903 78 µM -1.36409282347647 0.107687583586291 no 3012 0.08626917658146 4399 5509239 SGTC_2534 helenine 20.12 µM -1.3649746503208 0.107535101182598 no 3013 0.0861305087945469 4425 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1310 1188-0297 994 nM -1.36852669502054 0.106922469776312 no 3014 0.0855736359592901 4286 1588352 SGTC_2875 9039966 71.43 µM -1.3696888715269 0.106722573565109 no 3015 0.0853920220094464 4400 6463691 SGTC_101 0490-5701 117.494 µM -1.36982861424775 0.106698555770805 no 3016 0.0853702037985264 4277 4661669 SGTC_1640 st009078 66.4 µM -1.37038053988022 0.106603733601202 no 3017 0.0852840717544232 4382 690618 SGTC_133 0724-0033 378.92 µM -1.37173648263525 0.106371037645269 no 3018 0.0850727434086381 4248 280309 SGTC_2071 5230951 39.92 µM -1.37180338332649 0.106359566190744 no 3019 0.0850623268742163 4454 1799272 SGTC_1435 4092-0789 56.7 µM -1.37227119477698 0.106279375574682 no 3020 0.0849895146653944 4406 2248285 SGTC_2016 5121758 140 µM -1.37234262278266 0.106267135477373 no 3021 0.0849784014122846 4352 2795203 SGTC_470 aa-861 153 µM -1.37848058043484 0.10521911818156 no 3022 0.0840274797685562 4382 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_680 0417-1641 114 µM -1.37941350757119 0.105060483815549 no 3023 0.0838836484626461 4441 2835990 SGTC_1274 0865-0114 173 µM -1.38572432835165 0.103991940131427 no 3024 0.0829155482608963 4415 870624 SGTC_1865 st057639 52.2 µM -1.38722096273858 0.10373969121323 no 3025 0.082687197589797 4420 688818 SGTC_100 0086-0128 49.5915 µM -1.39057693427823 0.103175676246863 no 3026 0.0821768774033453 4433 93297 SGTC_298 1391-0729 10 µM -1.39076630595572 0.103143916359402 no 3027 0.0821481517857953 4369 3237558 SGTC_3348 9149464 3.537 µM -1.39159916559417 0.103004320148088 no 3028 0.0820219058446393 4368 1951442 SGTC_1125 tnp00248 1.32998 µM -1.39215529350746 0.102911183589968 no 3029 0.0819376886851003 4462 24207736 SGTC_165 k038-0023 64.381 µM -1.39808915365763 0.101921227770711 no 3030 0.0810431482743227 4423 46368543 SGTC_2232 chlorophetanol 41.5365 µM -1.40637658722086 0.100550246855447 no 3031 0.0798061643972208 4509 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1358 1509-0022 2.48 µM -1.40641164813026 0.100544475488471 no 3032 0.0798009617057768 4463 3258434 SGTC_1443 4112-3303 14 µM -1.40645798288431 0.100536848707654 no 3033 0.0797940864810618 4481 704433 SGTC_802 4112-3352 742 µM -1.40873829354437 0.100162026958548 no 3034 0.0794562836493531 4477 704594 SGTC_393 acivicin 6.25 µM -1.40953427201648 0.100031430002291 no 3035 0.0793386234149691 4299 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1965 Pectolinarigenin 58.4 µM -1.4109754184752 0.0997952961412467 no 3036 0.0791259311372024 4421 5320438 An anti-inflammatory. SGTC_826 1683-5028 118 µM -1.41264636145084 0.0995220198663544 no 3037 0.0788798650886475 4484 722377 SGTC_2794 7785382 27.27 µM -1.41294331056469 0.0994735122728777 no 3038 0.0788361965616595 4438 2205081 SGTC_944 3370-0224 231 µM -1.41301409957383 0.0994619512116083 no 3039 0.0788257892270645 4424 4580514 SGTC_1928 4'-methoxychalcone 40.3 µM -1.41361178791312 0.0993643775886445 no 3040 0.0787379591338275 4457 641818 SGTC_125 0133-0007 11.75 µM -1.41639427454935 0.0989110530909302 no 3041 0.0783300496561877 4523 26541 SGTC_3047 9092122 49.47 µM -1.41931729612885 0.0984364642121699 no 3042 0.0779032658995562 4435 17173831 SGTC_1629 st005085 44.9 µM -1.42220657535917 0.0979689945808883 no 3043 0.0774831452500405 4407 24207091 SGTC_1840 st055363 71 µM -1.42455953328613 0.0975895023687621 no 3044 0.0771422822790938 4476 676033 SGTC_252 miconazole 1.30953 nM -1.42675739874173 0.0972359987111658 no 3045 0.0768249172684339 4361 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2720 fluspirilene 36.88 µM -1.42751740437019 0.0971139786513933 no 3046 0.0767154060769461 4435 3396 An atypical antipsychotic. SGTC_2165 5727197 32.143 µM -1.4279407806896 0.097046053697117 no 3047 0.0766544521842293 4507 1361712 SGTC_844 0330-0132 15.3 µM -1.42970583149965 0.0967632511017175 no 3048 0.0764007329348011 4515 2828079 SGTC_3286 9117135 37.221 µM -1.42992977425538 0.0967274135216889 no 3049 0.0763685877566827 4407 3438150 SGTC_1790 st045711 43.5 µM -1.43059607116468 0.0966208436145509 no 3050 0.076273007062778 4435 585119 SGTC_2405 ticlatone 3.52 µM -1.43194795268165 0.0964048839238523 no 3051 0.0760793586173916 4255 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_897 1000-0139 31.4 µM -1.43882439748088 0.0953118780087315 no 3052 0.075100141029438 4419 6151020 SGTC_2905 7799065 20.05 µM -1.44180719963978 0.0948406112590064 no 3053 0.0746783856295843 4347 1296806 SGTC_1040 k898-0338 155 µM -1.44213737921663 0.0947885503896 no 3054 0.0746318109932321 4446 20969351 SGTC_2495 cafestol 54.53 µM -1.44528592747841 0.0942931624396792 no 3055 0.0741887944991783 4460 16667697 An anti-infammatory. SGTC_2881 9058953 51.95 µM -1.44613379113422 0.0941600877363546 no 3056 0.0740698397882285 4410 17122249 SGTC_2732 terfenadine 20 µM -1.44699583542485 0.0940249294355646 no 3057 0.073949044984184 4534 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2427 5545055 42.75 µM -1.44832515997618 0.0938167878117487 no 3058 0.0737630671816744 4401 5372858 SGTC_180 1486-1293 102.781 µM -1.44950185550512 0.0936328283297458 no 3059 0.0735987412664781 4400 4140536 SGTC_1824 st053723 68.6 µM -1.45146680741983 0.0933262302291606 no 3060 0.0733249592307984 4482 675225 SGTC_262 fenpropimorph 62.5 µM -1.45378045633485 0.0929661753228887 no 3061 0.073003591778205 4490 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2431 5490079 200 µM -1.46057413098646 0.0919148653105721 no 3062 0.0720661749339007 4507 5722345 SGTC_651 3253-0966 34.4 µM -1.46071209480241 0.0918936072328734 no 3063 0.0720472342203061 4487 781462 SGTC_1673 st016611 27.3 µM -1.46619411440277 0.0910518576266055 no 3064 0.0712977057864046 4473 5226799 SGTC_2529 gangaleoidin 93.61 µM -1.46675341121792 0.0909663016318486 no 3065 0.0712215737510091 4468 4565183 SGTC_377 3970-0964 33.1 µM -1.46831062366737 0.0907284080290635 no 3066 0.0710099332505472 4470 16481235 SGTC_2789 5281112 71.43 µM -1.4690400732454 0.0906171297601147 no 3067 0.0709109601501648 4481 765948 SGTC_2272 7805186 180 µM -1.47024211012942 0.0904339788915645 no 3068 0.0707480967412154 4475 2956062 YPR165W RHO1 SGTC_2280 7785178 200 µM -1.47370126528326 0.0899084512301736 no 3069 0.0702810210207633 4460 2954328 SGTC_1075 aripiprazole 15.2 µM -1.47616025229174 0.0895362553036418 no 3070 0.069950438553706 4537 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1784 st039334 36.3 µM -1.4763343586805 0.0895099458039467 no 3071 0.0699270773903759 4473 3496984 SGTC_3254 9136651 49.47 µM -1.47762964441166 0.0893143935427479 no 3072 0.0697534675951818 4449 16454030 SGTC_1609 st001574 46.4 µM -1.47883004691226 0.0891334499497216 no 3073 0.0695928715788409 4475 3960012 SGTC_287 k060-0039 29.6 µM -1.47916271782538 0.0890833528544167 no 3074 0.0695484155726522 4514 5861974 SGTC_792 4534-1957 155 µM -1.4794994013432 0.0890326728384367 no 3075 0.0695034456152587 4448 1717904 SGTC_3185 9108267 49.47 µM -1.48076796725356 0.0888419119618384 no 3076 0.0693342076129443 4476 4910486 SGTC_1101 ebselen 5.29 µM -1.48084173711474 0.0888308281731188 no 3077 0.0693243758306933 4490 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1119 parthenolide 318.541 nM -1.48947001227321 0.0875415368861189 no 3078 0.0681818221361873 4532 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_981 1488-1094 54.9 µM -1.48973671699915 0.0875019078635113 no 3079 0.0681467381592216 4456 3449522 SGTC_866 0495-0101 262 µM -1.4915230904761 0.0872368199599498 no 3080 0.0679121067696815 4500 635694 SGTC_1054 3429-0080 167 µM -1.49184755558419 0.0871887355542496 no 3081 0.0678695568943147 4504 1162877 SGTC_997 3996-0078 137 µM -1.49705433323928 0.0864198171442436 no 3082 0.0671895604980811 4548 735687 SGTC_3032 9089427 49.47 µM -1.50061637086307 0.0858967163722374 no 3083 0.0667274072943825 4476 17173707 SGTC_1060 3448-7350 82 µM -1.50267997830195 0.085594752658069 no 3084 0.0664607940771526 4429 570178 SGTC_873 0591-4978 488 µM -1.51188145466978 0.0842579868335618 no 3085 0.06528201134801 4522 3305145 SGTC_1227 3909-8010 46.6 µM -1.51284832246018 0.0841184376624122 no 3086 0.0651590955559455 4487 15982272 SGTC_1408 3909-7976 48.8 µM -1.51366967169857 0.0840000277162 no 3087 0.0650548203612048 4538 24152374 SGTC_1302 1159-0335 255 µM -1.51469014353954 0.0838530856252333 no 3088 0.0649254458332866 4519 649284 SGTC_2528 xanthyletin 44.79 µM -1.51885685369822 0.0832551062811614 no 3089 0.0643992657292519 4532 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2316 5844804 197.44 µM -1.51942845663809 0.0831733242236873 no 3090 0.0643273418109205 4518 776813 SGTC_343 4130-2827 29.8 µM -1.52027390861496 0.0830524720017443 no 3091 0.0642210743571197 4488 1118244 SGTC_2075 5212009 200 µM -1.52322117356387 0.0826322109775902 no 3092 0.0638516902523784 4447 780898 SGTC_2931 9014674 55.67 µM -1.52366979348321 0.082568381270055 no 3093 0.0637956094005747 4459 2996810 SGTC_1191 1487-1166 10.6 µM -1.52859064137142 0.0818706767402324 no 3094 0.0631829787558863 4527 3955771 SGTC_821 1114-0266 29.2 µM -1.53400175817703 0.0811085986450494 no 3095 0.0625146101236944 4536 3123235 SGTC_14 0354-0009 295 µM -1.54330355919919 0.0798111022370318 no 3096 0.0613785702335028 4606 1713507 SGTC_1674 st016616 23.6 µM -1.54434275131538 0.0796671271170345 no 3097 0.0612526604759312 4480 625830 SGTC_678 1218-2179 85.9 µM -1.54509298712023 0.0795633077115281 no 3098 0.0611618865200342 4563 6820081 YOR116C RPO31 SGTC_2018 5133068 143 µM -1.54675974769704 0.0793330238425151 no 3099 0.0609605948988598 4484 785362 SGTC_2661 dactinomycin 12.96 µM -1.5489493657564 0.0790312678806207 no 3100 0.0606969462643633 4513 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_825 1988-2224 89.6 µM -1.55140783603189 0.0786934976623234 no 3101 0.060401989268472 4509 1180859 SGTC_107 0358-0022 2.6945 µM -1.56411447920972 0.0769651444599168 no 3102 0.0588953431096828 4550 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3109 9122853 49.47 µM -1.5644847735986 0.0769152133227922 no 3103 0.0588518830151766 4541 1234709 SGTC_2222 6885208 172.143 µM -1.56615516508326 0.0766902808714456 no 3104 0.0586561480291726 4551 609514 SGTC_930 2810-3379 265 µM -1.5683612046269 0.0763939858503408 no 3105 0.0583984298192965 4518 1015764 SGTC_2566 crystal violet carbinol 226 nM -1.57537657140593 0.0754575340163361 no 3106 0.0575847744815072 4489 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_8 0354-0001 70 µM -1.58234882835085 0.07453552998087 no 3107 0.0567849798070906 4534 4993152 SGTC_2997 9067075 71.4286 µM -1.58480559052177 0.0742127073272846 no 3108 0.0565052559118754 4498 27209819 SGTC_2817 7995342 71.43 µM -1.5857076239969 0.0740944470139984 no 3109 0.0564028244516524 4516 18879975 SGTC_1474 0330-0125 5.35 µM -1.58835234300503 0.0737485432099465 no 3110 0.0561033437654525 4598 X1474 SGTC_1867 st057372 64 µM -1.5907351534605 0.0734379527770884 no 3111 0.0558345960448777 4524 688837 SGTC_2033 5192550 145 µM -1.59158585786521 0.0733273092972027 no 3112 0.055738894891221 4548 182073 SGTC_12 0849-0099 9.267 µM -1.59260137830479 0.0731953966916468 no 3113 0.055624822073458 4493 6071388 SGTC_1707 st032323 6.317 µM -1.59343788029129 0.0730868744051231 no 3114 0.0555309967645714 4352 3132057 YMR211W DML1 SGTC_2855 9016525 58.44 µM -1.60373181930233 0.0717614676142138 no 3115 0.0543865894772393 4484 43811474 SGTC_1952 st077036 64.1 µM -1.6055591331967 0.0715281288919875 no 3116 0.0541854053622153 4564 2937007 SGTC_2314 7727897 200 µM -1.60982212436383 0.0709860303337269 no 3117 0.0537183469018781 4520 900724 SGTC_3290 9121031 71.43 µM -1.61060395543075 0.0708869529835954 no 3118 0.0536330355795838 4554 17014854 SGTC_2814 7977482 42.97 µM -1.61115351445773 0.0708173738542413 no 3119 0.0535731334219516 4538 6456762 SGTC_3092 9117248 49.47 µM -1.62253084597108 0.069388659997801 no 3120 0.0523448669941571 4660 17141857 SGTC_2695 st077686 51.995 µM -1.62557738065136 0.0690098837262145 no 3121 0.0520197951321152 4522 2876092 SGTC_380 3970-0968 6 µM -1.63147150845804 0.0682815921079841 no 3122 0.0513954334793325 4455 2891601 SGTC_74 000s-0487 160.283 µM -1.63200557854298 0.06821589539685 no 3123 0.0513391555057875 4434 677548 SGTC_2019 4016004 108 µM -1.63487293063565 0.0678640121584174 no 3124 0.0510378440682278 4570 45595336 SGTC_1469 k284-2957 126 µM -1.63709272478755 0.0675925616137957 no 3125 0.0508055482470053 4565 23884841 SGTC_2458 5808907 16.39 µM -1.63740717524234 0.0675541765455725 no 3126 0.0507727099869206 4659 2731747 SGTC_2917 7979103 53.79 µM -1.63861932138619 0.0674063670703057 no 3127 0.0506462829183212 4551 2980565 SGTC_1984 st072354 53.1 µM -1.63961932410223 0.0672846147063764 no 3128 0.0505421713126713 4458 5762938 SGTC_2079 5212404 121 µM -1.64751904490521 0.0663287757097175 no 3129 0.0497257024676746 4521 758462 SGTC_2645 abamectin 100 µM -1.64795501003797 0.0662763331730485 no 3130 0.0496809518568673 4523 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1616 st002734 56.1 µM -1.65148663888256 0.0658526940930762 no 3131 0.0493196233865516 4548 4026101 SGTC_760 0568-0725 82.9 µM -1.6587416616731 0.0649889997154441 no 3132 0.0485839302020158 4580 3916171 SGTC_2966 9084041 48.03 µM -1.66411020879008 0.064355566133829 no 3133 0.048045203655659 4522 17741380 SGTC_3124 9127567 49.47 µM -1.6655062601834 0.0641916349249094 no 3134 0.0479058978608804 4531 17592030 SGTC_2723 salbutamol 83.58 µM -1.66559016530455 0.0641817927234086 no 3135 0.0478975356513245 4586 9884233 β2-adrenoceptor agonist SGTC_2048 5246248 200 µM -1.66572454261593 0.0641660324990303 no 3136 0.0478841456821518 4581 677046 SGTC_1960 st011366 51.8 µM -1.66823367282054 0.0638723054370665 no 3137 0.0476346744265175 4608 3972846 SGTC_2557 derrustone 83.84 µM -1.67210895086953 0.0634207087131529 no 3138 0.0472514199588983 4540 629853 An antioxidant. SGTC_354 2783-3500 4.88 µM -1.67247206167964 0.0633785220845057 no 3139 0.0472156362848341 4555 6740761 SGTC_1722 st034304 3.6505 µM -1.67332334050423 0.0632797051753275 no 3140 0.0471318300102552 4518 4036148 YLR033W RSC58 SGTC_2301 7769476 200 µM -1.6767550441444 0.0628825671632593 no 3141 0.0467951960024646 4571 977820 SGTC_2111 5486399 200 µM -1.67846174412936 0.0626857816308492 no 3142 0.0466284963547317 4546 689674 SGTC_1003 4049-0218 100 µM -1.68308118357418 0.0621555594351644 no 3143 0.0461796882660165 4576 295161 SGTC_989 1501-0895 10.3 µM -1.68488187120013 0.0619498255841417 no 3144 0.0460056824528119 4578 2830112 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.68654320599464 0.0617604848968276 no 3145 0.045845610255203 4632 165521 SGTC_1150 3909-7983 10.9 µM -1.68930352688831 0.0614468930844868 no 3146 0.0455806389266169 4584 23965914 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.6922619403189 0.061112178835154 no 3147 0.0452980205715202 4580 2724278 An inhibitor of dopamine biosynthesis. SGTC_1470 k295-0292 231 µM -1.69241228438931 0.0610952070635166 no 3148 0.0452836958691175 4635 5045612 SGTC_2511 berberine 10.47 µM -1.69440737827721 0.060870337127447 no 3149 0.0450939492235531 4573 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3344 9148862 3.898 µM -1.69478758454531 0.0608275570330474 no 3150 0.0450578617763375 4615 4905352 SGTC_1569 carminic acid 40.6 µM -1.69644094819399 0.0606417970210176 no 3151 0.044901202242392 4636 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1213 1315-0166 115 µM -1.69769999767957 0.0605006371528074 no 3152 0.0447821991077074 4574 768401 SGTC_1007 4101-0031 70 µM -1.70440896523119 0.0597527834683078 no 3153 0.0441523550919886 4584 1146276 SGTC_2371 9071574 200 µM -1.70541374846256 0.0596414057824076 no 3154 0.044058642994776 4603 45596039 SGTC_2618 avocadyne 43.43 µM -1.70680097540888 0.0594879026011992 no 3155 0.0439295255408587 4536 3015189 SGTC_544 k015-0020 52.4 µM -1.70722987074703 0.059440506041097 no 3156 0.0438896675233854 4621 3008304 SGTC_719 2810-4230 27.3 µM -1.7128399724377 0.0588232648044697 no 3157 0.0433709920483298 4619 721079 SGTC_1197 1601-0112 267 µM -1.71795680875223 0.0582646906623079 no 3158 0.042902246825235 4563 7350313 SGTC_1774 st048371 48.465 µM -1.71808608811453 0.0582506321686446 no 3159 0.0428904569836092 4588 4242727 SGTC_3355 9151058 44.0485 µM -1.71938027782136 0.058110042235324 no 3160 0.0427725754938957 4609 17015728 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.72328932125647 0.0576870149804545 no 3161 0.0424181089564466 4612 5024745 SGTC_573 3702-0553 84.7 µM -1.72778494398252 0.057203507638441 no 3162 0.0420133938378074 4552 1222756 SGTC_314 1671-0008 2.74 µM -1.72887160376758 0.0570871166168267 no 3163 0.0419160386416602 4475 3913060 SGTC_1457 k015-0032 57.3 µM -1.72926807930515 0.0570446969736696 no 3164 0.0418805634166917 4602 4302660 SGTC_244 nsc-207895 1.295 µM -1.73160322005464 0.0567953592706289 no 3165 0.0416721162530091 4409 42640 SGTC_627 1391-0720 175 µM -1.73523541324229 0.0564092339967372 no 3166 0.0413495581662894 4595 997839 SGTC_2152 5568786 200 µM -1.73637592861875 0.056288417715197 no 3167 0.0412486928186025 4637 5399883 SGTC_1189 1431-2119 7.28 µM -1.73648491618697 0.0562768832062079 no 3168 0.0412390645830545 4609 3107275 SGTC_2062 5245942 200 µM -1.73861071398808 0.0560522755277685 no 3169 0.0410516303383802 4637 1376160 SGTC_2098 5376439 882.5 nM -1.73907505056009 0.056003308831395 no 3170 0.041010781276325 4634 2844116 SGTC_653 0203-0016 55.2 µM -1.7504122941265 0.0548181744336613 no 3171 0.0400235980626645 4656 295302 SGTC_2459 5811157 9.22 µM -1.75745963908294 0.0540915319369191 no 3172 0.0394197477751322 4561 2870684 YBR192W RIM2 SGTC_1684 st024538 14.6195 µM -1.76191772974415 0.0536358147654951 no 3173 0.0390415992960189 4601 6732859 SGTC_586 0957-0265 8.15 µM -1.76446428260502 0.0533768677747412 no 3174 0.0388269218439263 4535 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_248 streptozotocin 5.23457 mM -1.7656118283771 0.0532605035312061 no 3175 0.0387304971100815 4647 5300 DNA alkylating agent. SGTC_1029 k015-0030 64.7 µM -1.76992279707913 0.0528251553391318 no 3176 0.0383700012794968 4633 2208316 SGTC_1588 farnesol 29.9 µM -1.77043820093756 0.0527732961523923 no 3177 0.0383270853628149 4636 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_336 4111-0029 111 µM -1.77385651462981 0.0524303719879956 no 3178 0.0380434436077385 4637 3131175 SGTC_2344 7990960 76.95 µM -1.77768357777059 0.0520485437285814 no 3179 0.0377279191698961 4600 140813 SGTC_258 haloperidol 50.781 µM -1.78326523455475 0.051495622836384 no 3180 0.0372715688981899 4605 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2706 st078239 82.5 µM -1.78688252797734 0.0511397939407429 no 3181 0.03697823849491 4602 15434492 SGTC_1949 st076024 69.1 µM -1.78973205065552 0.05086086973759 no 3182 0.0367484986619051 4587 2921930 SGTC_304 1310-0298 97 µM -1.79006146252218 0.0508287036617276 no 3183 0.0367220156062478 4367 1550234 SGTC_3319 9138450 16.7555 µM -1.79842298009781 0.0500176369681513 no 3184 0.0360550019130121 4578 2029690 SGTC_1887 st057648 70.8 µM -1.80320298296074 0.0495586335140107 no 3185 0.0356781710945613 4626 688672 SGTC_1147 3809-1045 12.3 µM -1.80521591674478 0.049366348665333 no 3186 0.0355204505898585 4647 325925 SGTC_2338 7999974 200 µM -1.81191293472641 0.0487309022185226 no 3187 0.0349998252329524 4599 315925 SGTC_2326 6164455 177.58 µM -1.81372467026641 0.0485601240146242 no 3188 0.0348600624887318 4551 2888790 SGTC_721 1187-1332 279 µM -1.83521224974166 0.0465709398038823 no 3189 0.0332371234071429 4641 25730 SGTC_57 miconazole 162.5 nM -1.83977830776088 0.0461567847159676 no 3190 0.0329003956992671 4496 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_295 k015-0027 31 µM -1.8416040270921 0.0459920165857214 no 3191 0.0327665457817134 4686 3887424 SGTC_2822 7994718 71.43 µM -1.85378873602039 0.0449044332787747 no 3192 0.031884695300958 4646 1018011 SGTC_1677 st019204 53.9 µM -1.85658686856214 0.0446576237155728 no 3193 0.0316849767966312 4637 3945625 SGTC_534 k292-0788 63.4 µM -1.85688931825194 0.0446310116675053 no 3194 0.0316634512972239 4683 4146317 SGTC_1777 st045864 34.765 µM -1.857451895096 0.0445815454383823 no 3195 0.0316234445586473 4664 4691462 SGTC_636 0kpi-0074 126 µM -1.86325567242031 0.0440738049814255 no 3196 0.0312131517518768 4673 616434 SGTC_403 arphamenine a 50 µM -1.86332115150456 0.044068103288443 no 3197 0.0312085480055935 4662 5487158 An arginine aminopeptidase inhibitor. SGTC_371 0195-0006 7.36 µM -1.87080680343092 0.0434201889241314 no 3198 0.0306859321389047 4502 3928593 SGTC_163 TUB2.036 7.546 µM -1.87104550985899 0.0433996550986796 no 3199 0.0306693866483046 4594 15992207 YJR013W GPI14 SGTC_1360 1598-0022 39.8 µM -1.87363254841879 0.043177617334421 no 3200 0.0304905443266881 4653 761525 SGTC_1052 3253-3998 198 µM -1.87467399492427 0.0430884925180212 no 3201 0.0304187932949691 4617 5450317 SGTC_2364 9055074 200 µM -1.87905316393716 0.0427153573560127 no 3202 0.0301186171966406 4642 6470630 SGTC_2868 9035608 32.47 µM -1.88180073485768 0.0424825820819833 no 3203 0.0299315380058884 4638 6462614 SGTC_138 0850-0259 40.9225 µM -1.88261771028503 0.0424135658234775 no 3204 0.0298760972617902 4592 6813004 SGTC_3006 9075424 71.4286 µM -1.88385235247721 0.0423094381266208 no 3205 0.0297924748957248 4621 7465181 SGTC_1092 toremifene 6.32 µM -1.88723162040789 0.0420254936068105 no 3206 0.0295645895192547 4661 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1355 1499-0035 1.68 µM -1.88727523564779 0.0420218389242191 no 3207 0.0295616577521617 4665 1548538 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.89266945501372 0.0415718170259616 no 3208 0.0292009204410513 4605 2724 A muscle relaxant with antifungal properties. SGTC_1396 3511-0007 98.6 µM -1.89562231596971 0.0413271281162004 no 3209 0.0290050021119466 4669 X1396 SGTC_7 0192-1582 4.227 µM -1.89657450475519 0.0412484743315834 no 3210 0.0289420590654813 4685 252616 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.89840750623869 0.0410974043216261 no 3211 0.0288212107908565 4593 5711223 A potent inhibitor of glutathione S-transferases. SGTC_850 0388-0143 75.9 µM -1.90746340259203 0.0403576180090538 no 3212 0.0282303029268136 4671 67273 SGTC_2264 7948757 110.76 µM -1.92250264721825 0.0391529660783711 no 3213 0.0272712704102473 4625 2971411 SGTC_3138 9097216 49.47 µM -1.92285631072839 0.0391249935757877 no 3214 0.0272490489340793 4615 25237486 SGTC_2135 5326629 150.42 µM -1.92333417924291 0.0390872231016885 no 3215 0.0272190473719213 4633 5020077 SGTC_1664 st014217 9.02 µM -1.92740789283057 0.0387664426440014 no 3216 0.0269644083817523 4714 3982782 SGTC_1287 0971-0001 34.6 µM -1.92933765765549 0.0386152355481788 no 3217 0.0268444788265306 4656 4665869 SGTC_2869 9037858 32.47 µM -1.93547552044561 0.0381374944738335 no 3218 0.0264659848999331 4627 27187042 SGTC_1857 st056007 79.3 µM -1.94044660836735 0.0377541122194073 no 3219 0.0261627184616184 4659 619834 SGTC_2802 7925815 54.55 µM -1.94409068042543 0.0374750755027406 no 3220 0.0259422584577894 4647 1262923 SGTC_1186 1319-0216 26 µM -1.94619708911911 0.0373145515809962 no 3221 0.0258155347293092 4694 4565136 SGTC_2365 9042475 200 µM -1.94645431822025 0.0372949873645099 no 3222 0.0258000951123797 4665 6464479 SGTC_2065 5221596 34.26 µM -1.94762908976874 0.037205743616066 no 3223 0.0257296802108942 4642 788581 SGTC_1204 4049-0315 18.3 µM -1.96100124042828 0.0362021485661239 no 3224 0.0249394390986077 4653 588402 SGTC_259 usnic acid 108.925 µM -1.96866952453104 0.0356367058900897 no 3225 0.0244955265460743 4687 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1992 st073643 23.3 µM -1.97441336714302 0.0352179262462089 no 3226 0.0241673796674003 4675 3161292 SGTC_3078 9116413 49.47 µM -1.97758117165323 0.0349886964429753 no 3227 0.023987987530205 4647 17177322 SGTC_1720 st037298 9.481 µM -1.98475819960941 0.0344738779929486 no 3228 0.0235856900861421 4653 597396 SGTC_1393 3470-5649 58.2 µM -1.98476593499445 0.0344733264986015 no 3229 0.02358525957131 4682 4108395 SGTC_1669 st015249 58.4 µM -1.98505435839476 0.0344527685229021 no 3230 0.0235692120103606 4756 722793 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.99253747355602 0.0339229052202122 no 3231 0.0231560589154631 4671 97141 SGTC_3325 9138760 55.175 µM -2.00517930151291 0.0330430013243062 no 3232 0.0224719410227858 4638 43844959 SGTC_3294 9122953 26.2835 µM -2.00760445308387 0.0328763731810404 no 3233 0.0223426704940435 4661 16459826 SGTC_2821 7996764 71.43 µM -2.01662856075483 0.0322624145603269 no 3234 0.0218671450942558 4643 2987135 SGTC_2047 4141938 200 µM -2.01998284455237 0.0320366304504249 no 3235 0.0216925835259374 4706 3807862 SGTC_1849 st056239 19.2 µM -2.02189076530444 0.031908787352787 no 3236 0.021593819002434 4681 5393181 SGTC_2889 9059656 51.95 µM -2.02417262786722 0.0317564413498238 no 3237 0.02147619644676 4712 3949838 SGTC_1548 st061468 90.8 µM -2.02983241451816 0.0313811643775385 no 3238 0.0211867884396122 4730 390799 SGTC_1943 st076331 65.2 µM -2.03024329107119 0.0313540642220385 no 3239 0.0211659076942742 4662 24208415 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.03376599420069 0.0311225108477262 no 3240 0.0209875973464443 4671 61125 An anti-inflammatory. SGTC_1561 5-methoxyflavone 52.9 µM -2.03865155975087 0.0308037173974446 no 3241 0.0207424077352163 4681 94525 SGTC_2120 5538279 151.968 µM -2.05160520134861 0.0299715300188404 no 3242 0.0201040231480204 4706 2058197 SGTC_1291 0993-0025 5.79 µM -2.05402481902277 0.0298181706491475 no 3243 0.0199866448143983 4678 4353356 SGTC_118 0083-0097 135.343 µM -2.05636770527476 0.0296702955433762 no 3244 0.0198735433585274 4666 5207356 SGTC_1097 itavastatin 7.23 µM -2.05641972858104 0.0296670189260884 no 3245 0.0198710381406103 4699 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1643 st009866 20.2 µM -2.06409796934149 0.0291866975364681 no 3246 0.0195042142366846 4692 3156273 YOR207C RET1 SGTC_2968 9090663 33.37 µM -2.079060203519 0.02826927005695 no 3247 0.0188059086596542 4648 25236811 SGTC_2813 7971799 71.43 µM -2.08744413720493 0.0277657775492597 no 3248 0.0184240028743321 4678 2234054 SGTC_2328 6201408 200 µM -2.09654869093511 0.0272274942974008 no 3249 0.0180167726824658 4650 2890418 SGTC_1243 0416-0003 5.65 µM -2.10986499071703 0.0264559019249374 no 3250 0.0174349932671138 4683 2141977 SGTC_1763 st044482 94.5 µM -2.11240941400474 0.0263105682027013 no 3251 0.0173256741206869 4705 88505 SGTC_2408 sulbentine 18.36 µM -2.11751293350356 0.0260210739720762 no 3252 0.0171081694050938 4592 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_126 0417-1624 672.48 µM -2.12109789176597 0.0258193163429143 no 3253 0.016956782668648 4728 41912 YDL195W SEC31 SGTC_3065 9113888 49.47 µM -2.1227972910515 0.0257241342930248 no 3254 0.0168854209762681 4710 16648368 SGTC_1122 capsaicin 818.572 nM -2.13432026443695 0.0250864593896119 no 3255 0.0164082867860577 4712 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_752 1896-0090 130 µM -2.1352589233819 0.0250351033090535 no 3256 0.0163699331055556 4729 772567 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.1352964930041 0.0250330496287334 no 3257 0.0163683996069044 4691 6857784 SGTC_2168 5727979 200 µM -2.13854429087316 0.024856047263328 no 3258 0.0162362967127057 4662 695210 SGTC_823 0417-1665 178 µM -2.14102508924575 0.0247215538686797 no 3259 0.0161360074300513 4721 3429856 SGTC_1352 1496-0991 99 µM -2.14328901921847 0.0245993510193103 no 3260 0.0160449490063883 4717 3000039 SGTC_2687 chenodiol 100 µM -2.1635989133093 0.0235255636985857 no 3261 0.0152475725079555 4723 5702181 A cholesterol synthesis inhibitor. SGTC_3323 9138564 53.9225 µM -2.16479514496158 0.0234635678476441 no 3262 0.0152016883965258 4731 43912313 YNL103W MET4 SGTC_2432 5630864 12.22 µM -2.16572027533282 0.023415716388102 no 3263 0.0151662843616882 4710 5714970 SGTC_2355 9061122 103.12 µM -2.1678702561446 0.0233048278224666 no 3264 0.0150842797477704 4722 5302957 SGTC_2544 sphondin 68.51 µM -2.16937508860713 0.0232274769867747 no 3265 0.0150271093342156 4681 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_690 glyoxal 20.3 µM -2.16963205322888 0.0232142902142546 no 3266 0.0150173655747845 4550 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1856 st057054 55.7 µM -2.18234201108146 0.0225698678200216 no 3267 0.0145421503187078 4704 1266018 SGTC_2386 9075165 157.42 µM -2.18298529182562 0.0225376571161484 no 3268 0.0145184465875379 4719 16452277 SGTC_1618 st003135 44.5 µM -2.18693566813634 0.0223407004547893 no 3269 0.0143736103231678 4713 1270615 SGTC_1632 st005650 90 µM -2.18718659712307 0.0223282389087366 no 3270 0.0143644524564958 4721 2759605 SGTC_1280 0880-0253 10.1 µM -2.18964931928375 0.0222062469591712 no 3271 0.0142748396328335 4729 6836607 SGTC_1920 st075728 45.7 µM -2.19427305652209 0.0219787272115085 no 3272 0.0141078926131879 4702 3400306 SGTC_555 4296-0685 37 µM -2.19428839494246 0.0219779757431153 no 3273 0.0141073416083386 4717 2908540 YHR072W ERG7 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -2.20639417159295 0.0213916089687558 no 3274 0.0136782063876513 4714 688761 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.20788197196487 0.0213204655619059 no 3275 0.0136262509367656 4687 364106 SGTC_2892 9047358 58.44 µM -2.20989281146675 0.021224629580717 no 3276 0.0135563011297515 4726 6466771 SGTC_3116 9124943 49.47 µM -2.22182361268368 0.0206634752770841 no 3277 0.0131476141544135 4724 41905195 YPL160W CDC60 SGTC_1266 0828-0227 32.9 µM -2.23287059866551 0.0201551447204592 no 3278 0.0127787394797469 4698 3913820 SGTC_714 4296-0578 26.1 µM -2.2341245616697 0.0200981191320746 no 3279 0.0127374391606471 4759 1589775 SGTC_814 3342-0569 96 µM -2.24793205710665 0.0194792030881357 no 3280 0.0122902613300973 4754 4346283 SGTC_299 1273-0059 1.44 µM -2.26709891849563 0.0186469452555961 no 3281 0.0116920918192697 4514 2848077 SGTC_2136 5328288 199.296 µM -2.2741617361443 0.0183479928118511 no 3282 0.0114781319621279 4706 262395 SGTC_3019 9081971 49.47 µM -2.277619915849 0.0182031114388309 no 3283 0.0113746164314536 4724 16451803 SGTC_2110 5483698 200 µM -2.27784732395664 0.0181936183736624 no 3284 0.0113678378185905 4722 2848765 YHR062C RPP1 SGTC_1041 0206-0046 107 µM -2.27931389758207 0.0181324981000093 no 3285 0.0113242062414482 4727 50494 SGTC_1193 1488-0126 41.5 µM -2.27997514620954 0.0181049974903983 no 3286 0.0113045812882736 4723 1384710 SGTC_1145 3546-0597 10.2 µM -2.28454517619199 0.0179159051755212 no 3287 0.0111697553699873 4733 875334 SGTC_1870 st057514 26.5 µM -2.28516325801936 0.0178904608063482 no 3288 0.0111516283617717 4738 5393161 SGTC_1265 0819-1001 68.8 µM -2.3096338128307 0.0169075622709554 no 3289 0.0104542179849003 4696 3106768 SGTC_2762 leflunomide 42.06 µM -2.30994354055076 0.0168954235788091 no 3290 0.0104456400499069 4716 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2133 5320837 200 µM -2.33373756091131 0.0159849115206936 no 3291 0.00980473401540831 4725 2841355 SGTC_2117 5521686 200 µM -2.34109732953959 0.0157119367229778 no 3292 0.00961357700033005 4747 803312 SGTC_3233 9132340 49.47 µM -2.3525295792343 0.0152958457804654 no 3293 0.00932310334659883 4747 17682950 SGTC_1594 piperine 70.1 µM -2.37569401432529 0.0144816914144512 no 3294 0.00875799064660607 4746 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3028 9087778 49.47 µM -2.3927734306634 0.0139055547993305 no 3295 0.00836078169197064 4730 17217395 SGTC_3145 9085516 49.47 µM -2.4089208987301 0.0133791401861496 no 3296 0.00799988266718736 4727 25236195 SGTC_2171 5739187 198.077 µM -2.44197069278879 0.012355143246032 no 3297 0.00730366619926336 4735 2262761 SGTC_3115 9123671 49.47 µM -2.44314308454661 0.0123201008534096 no 3298 0.00727998169862598 4789 3286988 SGTC_1100 amiodarone 5.07 µM -2.44925439082661 0.0121388268722262 no 3299 0.0071576151651342 4768 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1027 k015-0025 8.67 µM -2.45153883953655 0.0120716614912911 no 3300 0.00711234171465368 4738 3598955 SGTC_344 k064-0035 6.43 µM -2.45983766149796 0.0118303708114863 no 3301 0.00694999368510053 4719 5088750 SGTC_2003 4023581 200 µM -2.46099240440351 0.0117971301975054 no 3302 0.00692766496635654 4742 16641307 SGTC_3058 9093861 49.47 µM -2.46975030932707 0.0115476516298516 no 3303 0.00676036946412067 4756 17217477 SGTC_775 4577-0580 57.3 µM -2.47940133722704 0.0112780499159619 no 3304 0.0065801566767277 4749 2006902 SGTC_2777 climbazole 1.536 µM -2.48879045832319 0.0110210316739066 no 3305 0.00640892435985532 4583 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3302 9125395 16.351 µM -2.50879405840549 0.0104903903877997 no 3306 0.00605720448123108 4730 17599668 SGTC_1675 st018485 24.5 µM -2.50890237638947 0.010487578698446 no 3307 0.00605534746136976 4743 3323024 SGTC_1131 3454-3128 32.3 µM -2.53843083166681 0.00974516189674044 no 3308 0.00556754057499755 4727 710982 SGTC_2132 5317594 122.667 µM -2.54896085457222 0.00949174459513559 no 3309 0.00540222135867728 4731 794577 SGTC_2779 methotrexate 400 µM -2.58029033243355 0.00877153101659549 no 3310 0.00493586407584125 4750 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -2.58702472227752 0.0086231279219223 no 3311 0.00484043230299122 4772 6708784 An antioxidant flavonoid SGTC_1415 3966-0071 78.1 µM -2.58954544730957 0.00856814877882264 no 3312 0.00480513682032862 4727 2893185 SGTC_1365 1672-3266 55.4 µM -2.61389881040329 0.00805262145910564 no 3313 0.00447577719626931 4772 6415873 SGTC_750 4073-0104 132 µM -2.61694221284681 0.00799015296052158 no 3314 0.00443606799670752 4569 22330957 SGTC_5 0352-0601 109.883 µM -2.62463935704807 0.00783406010135231 no 3315 0.00433703942213183 4707 762456 SGTC_3104 9120930 49.47 µM -2.64071567604817 0.00751667142929714 no 3316 0.00413655581579238 4761 17014836 SGTC_713 1488-1073 324 µM -2.6455598882095 0.00742328122546463 no 3317 0.0040777924544244 4772 3312542 SGTC_34 0469-0683 81.75 µM -2.64782465101506 0.00737997133464948 no 3318 0.0040505766438387 4777 3690923 SGTC_142 0335-0849 62.6745 µM -2.70295005028754 0.00639226347301332 no 3319 0.00343635367442461 4743 3889043 YPR107C YTH1 SGTC_2750 bromebric acid 70.15 µM -2.73556875759044 0.00586459033001028 no 3320 0.00311362875864352 4775 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3025 9087895 49.47 µM -2.74751225858017 0.00568126846045645 no 3321 0.00300246320375525 4780 17173641 SGTC_1602 st001878 87.6 µM -2.75309760658592 0.00559729785861969 no 3322 0.00295171463536891 4775 595405 YLR310C CDC25 SGTC_3122 9126309 49.47 µM -2.75445429857136 0.00557706836862656 no 3323 0.00293950499754704 4798 17591206 SGTC_849 0386-0493 241 µM -2.76988557907536 0.00535150331206151 no 3324 0.0028037994038279 4783 726119 SGTC_965 1291-5240 308 µM -2.77461732484225 0.00528398163783736 no 3325 0.00276333477847433 4768 2834598 SGTC_158 k038-0087 26.446 µM -2.78756929744672 0.00510301778891642 no 3326 0.00265525475447576 4735 X158 SGTC_2980 9014342 25.29 µM -2.82964650000569 0.00455259673796743 no 3327 0.00232997300765618 4765 2996599 SGTC_554 4483-2211 187 µM -2.86543817852395 0.00412678876277277 no 3328 0.00208216287571192 4793 747107 SGTC_2793 7325131 81.82 µM -2.86570024258007 0.00412380708572654 no 3329 0.0020804401512966 4768 4176441 SGTC_2267 7931562 200 µM -2.91095617968643 0.00363691284715407 no 3330 0.00180162274081062 4768 934880 SGTC_2417 cerulenin 830 nM -2.91145719286434 0.00363182430052195 no 3331 0.00179873598947705 4777 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_829 1635-0120 117 µM -2.93733569925001 0.00337752080751325 no 3332 0.00165522768113133 4781 285054 SGTC_847 0342-0274 5.54 µM -2.96507984918533 0.0031227639458672 no 3333 0.00151302187727516 4797 18097 SGTC_1526 st051518 75 µM -3.01033770152874 0.00274412523685665 no 3334 0.001304786849774 4773 673993 SGTC_1146 3579-1023 7 µM -3.03198003967513 0.00257814366828715 no 3335 0.00121477634454132 4792 X1146 SGTC_1264 0783-0040 158 µM -3.12159492404816 0.00198317914406028 no 3336 0.00089937124459508 4772 2855798 SGTC_1082 camptothecin 424.86 nM -3.24079986081205 0.00138492185759038 no 3337 0.000595974183827264 4741 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2818 7996756 12.99 µM -3.37718258939645 0.000905478508283068 yes 3338 0.000366162099233669 4795 2241621 SGTC_35 0133-0054 64.071 µM -3.40803760384215 0.000820757675749509 yes 3339 0.000327159385009923 4780 99677 SGTC_137 0438-0332 85.389 µM -3.61570056263928 0.000415239146920417 yes 3340 0.00014976822929525 4781 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3333 9141820 12.094 µM -3.78870963145605 0.000229109992627275 yes 3341 7.57158909943507e-05 4796 1939433 SGTC_2270 7924575 90.91 µM -3.826575040026 0.000200491416853448 yes 3342 6.49692755205296e-05 4801 1262135 SGTC_58 0957-0393 9 µM -3.93990821904386 0.000133532258339141 yes 3343 4.07563941329796e-05 4613 6997992 SGTC_40 0327-0103 19.753 µM -4.07717404628489 8.046971801982e-05 yes 3344 2.27931849871925e-05 4763 409036 SGTC_2274 7947094 46.08 µM -4.18093655096364 5.43084010098725e-05 yes 3345 1.4515543571665e-05 4804 2971028 SGTC_310 1273-0058 1.06 µM -4.33187806243899 3.01666299172134e-05 yes 3346 7.39214091221586e-06 4655 2734232 SGTC_36 0335-0881 14.2 µM -4.39696261343332 2.32748537904007e-05 yes 3347 5.48881222688444e-06 4801 23828853 SGTC_453 enantio-paf c16 10 µM -4.50306628281982 1.51345584919964e-05 yes 3348 3.34899911142806e-06 4620 13871343 A lipid and platelet activating factor