SGTCid condition conc unit VPS29|YHR012W.score VPS29|YHR012W.strain.pval VPS29|YHR012W.strain.significant VPS29|YHR012W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_232 clozapine 119 µM 22.0182421477262 2.97536034583153e-91 yes 1 9.62952991930952e-108 3 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_221 trifluoperazine 10.304 µM 21.0289717911448 1.981579134745e-83 yes 2 1.78144262862825e-98 10 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2697 mebhydrolin 72.4 µM 20.4810463811488 2.99371614567806e-79 yes 3 1.58879344989245e-93 4 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3152 9099253 49.47 µM 16.7936032186411 5.59618001472314e-54 yes 4 1.35914367582754e-63 4 25236131 SGTC_1844 rapamycin 4 nM 15.9970156394647 3.58927560420436e-49 yes 5 6.70242730590921e-58 11 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_301 4119-0100 24.5 µM 15.5610732491765 1.22381722980001e-46 yes 6 6.69178615211431e-55 5 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_206 4546-0025 72.014 µM 15.070442036256 7.1652098198379e-44 yes 7 1.26705933682328e-51 7 6620745 YIL048W NEO1 SGTC_1760 st045453 10.4495 µM 14.4675793200462 1.36645787298483e-40 yes 8 9.70933876562102e-48 14 3323419 YIL048W NEO1 SGTC_1803 st050068 52.4 µM 13.7274578206389 9.58644590502541e-37 yes 9 3.47653216415206e-43 5 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1754 st042065 16.137 µM 12.2222901022711 1.54096421381559e-29 yes 10 1.18165969315902e-34 14 1126236 YIL048W NEO1 SGTC_888 0916-0002 6.97 µM 10.7026901540151 4.23645122550171e-23 yes 11 4.94327659277199e-27 8 2802138 YIL048W NEO1 SGTC_1712 st032288 53.4 µM 10.4683533046687 3.51028445371417e-22 yes 12 6.03623723369824e-26 22 2883011 SGTC_1781 st038725 66.3 µM 9.57894514508195 7.07275993593347e-19 yes 13 4.90205571858921e-22 19 4270275 YIL048W NEO1 SGTC_43 0570-0105 72.5 µM 9.43806296123368 2.22168626521161e-18 yes 14 1.89867083465389e-21 12 1114046 YDL195W SEC31 SGTC_2679 rapamycin 1 nM 8.60209996751926 1.40796638271176e-15 yes 15 3.91352853698755e-18 35 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_445 e6 berbamine 66 µM 8.2083034012979 2.40430702046989e-14 yes 16 1.12167878739979e-16 11 6610268 A calcium/calmodulin antagonist. SGTC_449 xestospongin c 11.1929 µM 7.85430015305223 2.76125745236277e-13 yes 17 2.01005255547465e-15 5 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_535 2293-4129 48.2 µM 7.80727694709775 3.78902300331465e-13 yes 18 2.92183845006091e-15 13 396118 YIL048W NEO1 SGTC_1801 st050089 28.441 µM 7.52221506512172 2.48055608635485e-12 yes 19 2.69279484412851e-14 31 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_528 3492-0019 172 µM 7.45292311156176 3.87692603428865e-12 yes 20 4.56472473329514e-14 89 2869262 SGTC_1800 st050079 29.0735 µM 7.33788474845914 8.06587332585115e-12 yes 21 1.08497948139252e-13 19 3645560 SGTC_3037 9091026 49.47 µM 7.24014250796158 1.49018984892555e-11 yes 22 2.24106763846697e-13 22 25236398 YIL048W NEO1 SGTC_1130 3454-2858 15.9 µM 7.12841976581037 2.97687193787265e-11 yes 23 5.0763875930064e-13 28 715628 YIL048W NEO1 SGTC_1991 st073000 8.92 µM 6.65127941389747 5.09093322377028e-10 yes 24 1.45278037591114e-11 25 4301969 YIL048W NEO1 SGTC_447 ml7 120 µM 6.5703251157467 8.08922278269542e-10 yes 25 2.51027596731806e-11 5 4216 Selective myosin light chain kinase inhibitor. SGTC_900 1112-0045 141 µM 6.56231627493018 8.46593877297573e-10 yes 26 2.64891481622143e-11 7 56211 YIL048W NEO1 SGTC_2688 kanamycin b 96.69 µM 6.56065544116409 8.54617354354259e-10 yes 27 2.67858889022163e-11 125 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_313 3474-0040 5.03 µM 6.28968846600055 3.86300180260556e-09 yes 28 1.59051849902918e-10 21 1043375 YIL048W NEO1 SGTC_168 3970-0862 530.542 µM 6.02991965940014 1.55017614276287e-08 yes 29 8.20206039804227e-10 40 3135186 SGTC_2416 tofa 880 nM 5.92526360500747 2.67117248432449e-08 yes 30 1.55898409892877e-09 18 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3308 9128332 17.569 µM 5.89434981756501 3.13156186933296e-08 yes 31 1.88079765902116e-09 38 17332805 YDL196W YDL196W SGTC_2835 9006588 71.43 µM 5.87799970529932 3.40524469613535e-08 yes 32 2.07626829215257e-09 7 2345538 SGTC_227 fluconazole 33.516 µM 5.65499620180683 1.04459715550922e-07 yes 33 7.79248595184106e-09 45 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2249 haloperidol 116.36 µM 5.50294053195209 2.19150057905907e-07 yes 34 1.8675421819171e-08 53 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_562 3772-2733 112 µM 5.50097524271549 2.21231505238921e-07 yes 35 1.88848123644953e-08 39 2876874 YIL048W NEO1 SGTC_2617 dihydrotanshinone i 20.83 µM 5.43885594024026 2.97786401373261e-07 yes 36 2.68118954744711e-08 13 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1304 1165-0502 251 µM 5.43580680232497 3.02137380238694e-07 yes 37 2.72745178180259e-08 37 767425 SGTC_2021 4019055 173 µM 5.37860631966768 3.96069422602238e-07 yes 38 3.75323241273557e-08 57 44827708 YER133W GLC7 SGTC_2873 9040596 71.43 µM 5.35265787181698 4.47426903331254e-07 yes 39 4.33358139418148e-08 21 6463863 SGTC_3154 9100113 49.47 µM 5.30714951934609 5.533643486775e-07 yes 40 5.56764173828235e-08 11 25237525 SGTC_146 3448-8650 53.125 µM 5.29974390649082 5.72743376862085e-07 yes 41 5.79826117358679e-08 69 2891488 YIL048W NEO1 SGTC_654 1124-0271 80.9 µM 5.15297766131489 1.12258114423298e-06 yes 42 1.28191257964331e-07 6 5403748 SGTC_1687 st020778 55.3625 µM 5.06152656284235 1.69229036996886e-06 yes 43 2.07956389316871e-07 131 4259299 SGTC_1067 clotrimazole 1.36 µM 5.03948303712878 1.86638192323988e-06 yes 44 2.33395498726673e-07 22 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_15 0266-0086 27.098 µM 4.94711944837478 2.80105066685721e-06 yes 45 3.76598804300195e-07 33 1712902 YIL048W NEO1 SGTC_1495 4469-0029 237 µM 4.90237486421891 3.40138624157159e-06 yes 46 4.73424652474742e-07 74 793680 SGTC_1939 st074455 53.6 µM 4.8278262723227 4.68381026651844e-06 yes 47 6.90157126047717e-07 14 1644229 SGTC_2556 citropten 84.59 µM 4.71394546241643 7.5696183471132e-06 yes 48 1.21482859162231e-06 14 2775 A potential DNA crosslinker. SGTC_1740 st038286 13.222 µM 4.69680798336859 8.1292749580589e-06 yes 49 1.32129329210498e-06 15 716786 SGTC_1742 st038235 28.8875 µM 4.66576437138681 9.24493228901403e-06 yes 50 1.53735943243293e-06 90 564103 YBR002C RER2 SGTC_1917 st066507 28.5 µM 4.65677284501683 9.59439442971046e-06 yes 51 1.60602253314338e-06 24 3156428 SGTC_1062 mesoridazine 14.2 µM 4.54975707759783 1.48464778312396e-05 yes 52 2.68539410418068e-06 10 4078 A neuroleptic. SGTC_308 4092-1169 104 µM 4.43062852427198 2.3876378495359e-05 yes 53 4.69794134086491e-06 37 2268590 YDL196W YDL196W SGTC_264 promethazine 12.5 mM 4.40377397265866 2.65336867326388e-05 yes 54 5.3191891707762e-06 40 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2006 4011487 200 µM 4.33359477528722 3.48636405123623e-05 yes 55 7.33470423374427e-06 72 45595294 SGTC_1818 st052136 56.3 µM 4.31964734170273 3.6790305381254e-05 yes 56 7.81393692837851e-06 35 674169 SGTC_61 0978-8327 98.565 µM 4.25292479559639 4.7484066874716e-05 yes 57 1.05498225681192e-05 24 6150059 YHR072W ERG7 SGTC_2610 ononetin 44.17 µM 4.24797471074561 4.8384609067836e-05 yes 58 1.0785586876999e-05 31 259632 SGTC_649 1123-0311 367 µM 4.08502865155512 8.88235974594558e-05 yes 59 2.20356890479363e-05 63 693629 YIL048W NEO1 SGTC_2059 5238311 157 µM 4.01901362656306 0.000112922883086273 yes 60 2.92211456217709e-05 23 703021 SGTC_1547 harmine 94.2 µM 3.94870352029475 0.000145262807104225 yes 61 3.92877980472478e-05 39 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_699 0375-0592 111 µM 3.91795647574306 0.000161973834557752 yes 62 4.46514126946994e-05 19 762578 SGTC_852 0418-0143 439 µM 3.90463982416788 0.000169755885788073 yes 63 4.71829102128717e-05 71 5369229 SGTC_443 clozapine 122 µM 3.87639710957618 0.000187432366721129 yes 64 5.30073048338958e-05 11 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2290 7904846 200 µM 3.87237270857883 0.000190086878525508 yes 65 5.38904842304125e-05 23 2962154 SGTC_940 3232-1287 54.8 µM 3.83088943954866 0.000219574412913171 yes 66 6.38404359097187e-05 44 1585493 YIL048W NEO1 SGTC_1658 st012944 20 µM 3.80545120185499 0.000239713695214801 yes 67 7.07729600540549e-05 82 24207260 SGTC_1597 7-benzyloxygramine 47.5 µM 3.74733738880157 0.000292360726551044 yes 68 8.93608119213359e-05 135 260807 SGTC_653 0203-0016 55.2 µM 3.74439896226979 0.000295289455856934 yes 69 9.04130627167864e-05 22 295302 SGTC_2776 terbinafine 19.92 µM 3.69999193057504 0.000343009331961268 yes 70 0.000107803161261077 63 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 3.69600420888919 0.000347628057540005 yes 71 0.000109509671252004 15 616764 SGTC_1192 1488-0095 21.4 µM 3.68957460440616 0.000355196956850424 yes 72 0.000112314674611016 20 915875 SGTC_3299 9121982 43.1275 µM 3.65379322028594 0.000400190931252486 yes 73 0.000129197195596348 41 17594604 YPL160W CDC60 SGTC_1797 st048695 56.8 µM 3.59701930944925 0.000482558427377432 yes 74 0.000160942298446271 80 592262 YIL048W NEO1 SGTC_1836 st055642 81 µM 3.58842792558095 0.000496310551929906 yes 75 0.000166338966287502 29 8571 SGTC_2322 7413319 38.22 µM 3.57778831844473 0.00051384405116844 yes 76 0.000173256949178471 182 1840400 SGTC_805 3852-0218 479 µM 3.51442374649192 0.000630699341947802 yes 77 0.000220354589954425 88 6615355 SGTC_3216 9129716 49.47 µM 3.43665622305403 0.000807529859800419 yes 78 0.000294471301044805 41 8056934 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 3.4321752235283 0.000818993041945193 yes 79 0.000299380281272131 53 551469 SGTC_2300 7976697 71.57 µM 3.42893598694958 0.000827372620982483 yes 80 0.000302976213434392 49 2236109 SGTC_1305 1181-0477 144 µM 3.42580328846903 0.000835551567069025 yes 81 0.000306492074946007 31 6252086 SGTC_2665 lovastatin 100 µM 3.393652595375 0.000923897092004603 yes 82 0.00034483561380583 29 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1943 st076331 65.2 µM 3.38935287287068 0.000936341862827418 yes 83 0.000350288962857344 31 24208415 SGTC_3333 9141820 12.094 µM 3.38201211725013 0.000957944753175586 yes 84 0.000359784852557461 28 1939433 SGTC_214 4373-3496 70 µM 3.26900102063086 0.0013536971318947 no 85 0.00053963956113544 110 3779166 SGTC_658 3253-0951 102 µM 3.2377785869846 0.00148677550206662 no 86 0.00060232130631018 95 1184878 SGTC_1954 st077032 68.9 µM 3.23327747475238 0.00150691547426679 no 87 0.000611893174968987 50 698907 SGTC_2332 7982454 138.89 µM 3.21298868211865 0.00160082155043507 no 88 0.00065680732951264 89 2981748 SGTC_1660 st012960 28.1 µM 3.2106772970255 0.001611851426006 no 89 0.000662112756175275 71 24207266 SGTC_702 1488-0190 94 µM 3.19812199676828 0.00167298396101122 no 90 0.000691628741100145 37 949357 SGTC_2477 5967686 25.23 µM 3.18583488639863 0.00173484761469685 no 91 0.000721684735936203 56 776118 SGTC_2752 diclazuril 33.15 µM 3.17841721490547 0.00177319503684477 no 92 0.000740407493376994 182 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_459 nigericin 15.3 µM 3.17754797981235 0.00177773887410693 no 93 0.000742630562391859 95 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1075 aripiprazole 15.2 µM 3.16711775183499 0.00183309402707474 no 94 0.000769789822242816 67 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1230 0170-0365 3.77 µM 3.15864986906065 0.00187918234292764 no 95 0.000792508948973984 122 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2630 antimycin a 100 µM 3.15831065609902 0.00188105033484287 no 96 0.000793431779974579 74 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_770 0389-1121 67.2 µM 3.15217942697849 0.00191510626669603 no 97 0.000810283291809926 63 6753108 SGTC_825 1988-2224 89.6 µM 3.14773797045138 0.00194012521034804 no 98 0.000822695574809232 69 1180859 SGTC_2991 9074669 71.4286 µM 3.14479330311716 0.0019568759582726 no 99 0.000831021066395538 112 17333109 SGTC_2811 7967822 32.47 µM 3.11327332912736 0.00214458451144057 no 100 0.000925122878256126 46 2232244 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 3.11126871407183 0.0021570573953548 no 101 0.000931426691923626 49 390807 SGTC_2531 methyl deoxycholate 70.07 µM 3.1052812697335 0.00219470437989633 no 102 0.000950490804352043 63 16667744 Haematoxylin. SGTC_2541 muurolladie-3-one 83.07 µM 3.10325642692435 0.00220757002443982 no 103 0.000957018589810173 63 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2845 9003024 42.97 µM 3.09599462178568 0.00225427489657245 no 104 0.000980769596174366 85 2990173 SGTC_1656 st012921 11 µM 3.09411615520172 0.00226650125230254 no 105 0.000987000926687075 59 6732821 SGTC_2258 7960471 200 µM 3.08588114457588 0.00232081235995582 no 106 0.001014749647026 38 2974708 SGTC_1857 st056007 79.3 µM 3.06488501167236 0.00246465742049217 no 107 0.00108876849996496 31 619834 SGTC_1612 st002233 45.4 µM 3.0616702040076 0.0024873803783265 no 108 0.00110052907732143 60 1035021 SGTC_3137 9097352 49.47 µM 3.04552837302539 0.00260436354502637 no 109 0.00116135930986554 86 44120435 SGTC_2824 7998404 51.95 µM 3.04529003982147 0.00260612742725032 no 110 0.00116228009605521 65 837851 SGTC_1092 toremifene 6.32 µM 3.01122733953447 0.00286960686191012 no 111 0.00130096982721212 70 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_582 0987-0078 156 µM 3.00311996824722 0.00293575605607755 no 112 0.00133613533692089 141 1625765 SGTC_49 0717-0965 32.132 µM 2.99846884369403 0.00297432271492598 no 113 0.00135669949080506 61 5889349 YGL099W LSG1 SGTC_2257 7960413 200 µM 2.99496619207938 0.00300366708490559 no 114 0.00137237631052036 116 2974689 YIL048W NEO1 SGTC_684 1140-0066 328 µM 2.99355303944066 0.0030155797988155 no 115 0.00137874787606474 84 6813534 SGTC_811 0416-0114 265 µM 2.9877934561018 0.00306457391178507 no 116 0.00140499692149263 73 6612453 SGTC_2950 9072895 21.46 µM 2.96805741850425 0.00323794322434347 no 117 0.00149844170998262 97 17332245 SGTC_2654 protoveratrine a 100 µM 2.96223263358418 0.00329077036823534 no 118 0.00152708465952552 38 5702278 A heart drug and vasodilator. SGTC_2401 5128683 200 µM 2.96177539362207 0.00329494987615866 no 119 0.00152935410605123 83 708373 SGTC_2718 lomofungin 53.02 µM 2.94096296144143 0.00349031828119982 no 120 0.00163596827278193 49 5351222 A RNA synthesis inhibitor. SGTC_1665 st014639 11.4 µM 2.93955249505455 0.00350392748468597 no 121 0.00164343293398897 72 981133 YIL048W NEO1 SGTC_1949 st076024 69.1 µM 2.91620719505166 0.00373620825868902 no 122 0.00177157559467342 80 2921930 SGTC_3110 9122132 49.47 µM 2.90665012000633 0.0038352173890683 no 123 0.00182660779681923 51 918317 SGTC_3040 9091894 49.47 µM 2.90148715764511 0.00388967716776711 no 124 0.00185698001115495 52 25236966 SGTC_2952 9073731 13.78 µM 2.87910823494226 0.00413383002322082 no 125 0.00199400720072783 107 16457353 SGTC_1515 3460-0031 42.1 µM 2.8655978954738 0.00428778109124534 no 126 0.00208111279413924 50 2876596 SGTC_1258 0671-0043 57.1 µM 2.8653701356952 0.00429041978735053 no 127 0.0020826103788709 85 4298767 SGTC_518 1021-0119 62.6 µM 2.85989844141663 0.004354249660082 no 128 0.00211888348158469 104 1097762 SGTC_2383 9036125 200 µM 2.85701682454509 0.00438820507847081 no 129 0.00213821584896127 32 79580 SGTC_1026 k007-1105 30.6 µM 2.84710980453412 0.00450675625938632 no 130 0.00220590710026451 170 7066794 SGTC_1451 4152-0210 104 µM 2.8339667432813 0.00466844193867707 no 131 0.00229870581006486 93 659563 SGTC_439 amiodarone 34.4 µM 2.81524024184251 0.00490775483563665 no 132 0.0024370391076159 174 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3030 9087619 49.47 µM 2.80535159547777 0.00503848537701124 no 133 0.00251308602939452 67 25236973 SGTC_1970 st070122 35.8 µM 2.802182678016 0.0050810305840181 no 134 0.00253790614835994 94 102928 SGTC_507 nimesulide 162 µM 2.79931217654054 0.00511984510387406 no 135 0.00256058000938885 72 4495 A COX2 inhibitor. SGTC_1436 4092-1007 8.32 µM 2.78132216579023 0.00536917003967575 no 136 0.0027068991217716 60 2881121 SGTC_124 0136-0217 7.121 µM 2.74426870755431 0.00591696133227639 no 137 0.00303229369496559 136 3976905 SGTC_164 4100-3994 89.624 µM 2.73817051564621 0.00601171731438303 no 138 0.00308910166758131 114 4615967 SGTC_1068 loratadine 26.9 µM 2.72407385281972 0.00623592254060448 no 139 0.00322410427899806 91 3957 A H1 histamine antagonist. SGTC_1655 st012546 55.1 µM 2.71942422197085 0.00631148147050888 no 140 0.00326978386196259 83 720985 YLR208W SEC13 SGTC_3044 9093193 49.47 µM 2.70713457467395 0.00651511064340727 no 141 0.0033933370158703 108 25236277 SGTC_66 0109-0187 42.4 µM 2.70436000750694 0.00656187909473147 no 142 0.00342180497833355 98 759417 SGTC_2957 9076800 11.52 µM 2.69332425329645 0.00675085102976344 no 143 0.00353717154489892 81 16459615 SGTC_2146 5545642 200 µM 2.68857089519375 0.00683371651376234 no 144 0.00358792981361537 83 825326 SGTC_1394 3474-0001 65.7 µM 2.68739267167975 0.00685439497123538 no 145 0.00360061204460745 103 5017666 YIL048W NEO1 SGTC_1218 1348-1416 30.7 µM 2.6772723818875 0.00703429960128802 no 146 0.00371121331653329 83 6787668 SGTC_218 alverine citrate 93.75 µM 2.6740511489776 0.00709243012760538 no 147 0.00374705102487557 88 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1608 st001473 40.5 µM 2.67202866181681 0.00712914426736611 no 148 0.00376971042193158 107 7292267 SGTC_1926 methyl fluorone black 53.6 µM 2.66551217248167 0.00724858081154577 no 149 0.00384355743734669 129 72721 Reacts with homocysteine. SGTC_2036 5160441 105 µM 2.64192667512745 0.00769574275815411 no 150 0.00412179503024761 166 134534 YIL048W NEO1 SGTC_2485 5633444 17.78 µM 2.63818873227783 0.00776879683599385 no 151 0.00416750897104984 138 5724239 SGTC_1738 st035555 74 µM 2.62225684401901 0.00808705568609526 no 152 0.0043674787056182 125 5331140 SGTC_149 3970-0822 46.1 µM 2.60726793885685 0.00839688144053576 no 153 0.00456339558314568 239 3114250 YBL034C STU1 SGTC_1600 coumarin 106 71.1 µM 2.60524353256475 0.0084395153754033 no 154 0.00459044890287507 110 100336 A hepatotoxic, DNA x-linker. SGTC_2285 7945142 200 µM 2.60487755863508 0.00844724302115748 no 155 0.00459535487555163 103 2970608 SGTC_2870 9038528 12.99 µM 2.59821403875836 0.00858903516530646 no 156 0.00468550307718115 99 6463316 SGTC_195 4234-0266 16.654 µM 2.59786310336119 0.00859656020925783 no 157 0.00469029418393984 124 2303354 SGTC_2975 9084847 53.72 µM 2.59198621772156 0.00872343933154158 no 158 0.00477117971581061 125 27211724 SGTC_2395 5646831 180.19 µM 2.58956844895927 0.00877611264139696 no 159 0.00480481580781961 116 6808628 SGTC_867 0518-0118 155 µM 2.58607643010044 0.00885268157873341 no 160 0.00485377010682593 99 6848158 SGTC_2947 9072639 7.68 µM 2.58294978936457 0.00892173506644387 no 161 0.00489797892312505 160 16488146 SGTC_688 0527-0193 473 µM 2.57933409051144 0.00900217770046664 no 162 0.00494954985254422 67 4007154 SGTC_788 1182-0090 188 µM 2.56805810426219 0.00925714177474351 no 163 0.00511350060500206 203 5715185 SGTC_16 erodoxin 22.806 µM 2.56374628416223 0.00935629491189097 no 164 0.0051774603658048 166 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3283 9109332 35.8195 µM 2.540922910326 0.00989675686552555 no 165 0.00552801468039688 82 17027281 SGTC_2508 celastrol 40.54 µM 2.53905802223403 0.00994209915591788 no 166 0.0055575693808311 86 122724 Celastrol is a natural product and antioxidant. SGTC_45 0kpi-0036 14.9 µM 2.52911958583477 0.0101868103726447 no 167 0.0057174529294842 102 2795021 SGTC_3059 1327-0034 3 µM 2.52739616211294 0.0102297760802514 no 168 0.00574558995442835 148 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2189 6047310 154.431 µM 2.52439286798717 0.0103050272982319 no 169 0.00579491623163957 91 711535 SGTC_726 3448-4391 34.2 µM 2.51079743355948 0.0106517469487871 no 170 0.00602293985133146 117 1356692 SGTC_2361 9034121 116 µM 2.49566972040754 0.0110494450864094 no 171 0.00628597986363762 100 6496917 SGTC_2549 cedrol 20.94 µM 2.48838519244142 0.01124551518162 no 172 0.00641623309457567 99 6708665 A sedative which affects the nervous system. SGTC_2754 granisetron 64.02 µM 2.46528693432513 0.0118873590810107 no 173 0.00684517850081667 154 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2203 7227154 166.4 µM 2.45878406594015 0.0120736951961855 no 174 0.00697042197443502 84 896304 SGTC_1898 st060199 18.6 µM 2.45526844998889 0.0121754838949232 no 175 0.00703897071741302 94 688866 SGTC_342 k048-0088 23.3 µM 2.43190933620574 0.0128708834757865 no 176 0.00750973317983504 118 6820570 SGTC_1033 k072-0102 21.3 µM 2.42882383443484 0.0129652592863185 no 177 0.00757394530865982 148 5965931 SGTC_377 3970-0964 33.1 µM 2.42346180718266 0.0131306905981599 no 178 0.00768668485154395 207 16481235 SGTC_1222 0366-0074 1.18 µM 2.41928131158531 0.0132609313783402 no 179 0.00777560421906357 115 286520 SGTC_1549 4'-methoxyflavonol 74.6 µM 2.40357616752216 0.0137602357121167 no 180 0.00811779220482298 100 97141 SGTC_2090 5301565 104.445 µM 2.39677017698648 0.0139816013937877 no 181 0.00827014723033789 170 2056344 SGTC_225 nsc-122657 1.016 µM 2.39671159604666 0.0139835199941603 no 182 0.00827146941764157 62 275685 SGTC_835 0312-0010 67.2 µM 2.39146410406496 0.0141563052806974 no 183 0.0083906624264984 103 1626196 SGTC_3282 9108498 15.4605 µM 2.39123028965389 0.0141640467590502 no 184 0.00839600826525179 145 16459645 SGTC_1519 esterone 74 µM 2.38725213125077 0.0142963216446753 no 185 0.00848742257876008 139 698 A steroid. SGTC_1361 1608-0041 5.61 µM 2.38370998549246 0.014414993009028 no 186 0.0085695516416746 129 X1361 SGTC_2895 9054447 58.44 µM 2.37590349210777 0.0146795290269364 no 187 0.00875302040077975 90 2697450 SGTC_1518 st038567 90.8 µM 2.36653149702306 0.0150026219915658 no 188 0.00897782317447215 111 77966 SGTC_1090 efavirenz 20.7 µM 2.34779558424274 0.0156668869128988 no 189 0.00944244117227043 129 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_302 1094-0063 18.9 µM 2.34367000104876 0.0158164991082223 no 190 0.009547528969174 102 5440289 SGTC_1788 fluconazole 20 µM 2.33929915938024 0.0159763405471966 no 191 0.00965997809295445 172 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_576 1073-0113 22.7 µM 2.32454939293484 0.0165259995815975 no 192 0.0100480337623046 244 5439563 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.32441677129481 0.0165310143287803 no 193 0.0100515837741236 124 7104 SGTC_1416 3966-0321 25.3 µM 2.32425679584469 0.0165370651232515 no 194 0.0100558674483116 149 582530 YLR208W SEC13 SGTC_254 nsc-64875 3.808 µM 2.31692423120621 0.0168164487730047 no 195 0.0102539297707721 133 56993 SGTC_145 3737-0113 38.366 µM 2.31239085947572 0.0169911899352202 no 196 0.0103780768114695 235 6849351 SGTC_1463 k081-0032 34.1 µM 2.30320266357963 0.0173501190838016 no 197 0.0106337215196492 86 977755 SGTC_402 epigallocatechin gallate 10 µM 2.30110028270462 0.01743315120335 no 198 0.0106929816823423 180 65064 An antioxidant. SGTC_694 1315-0438 43.2 µM 2.29813529992111 0.0175508277483272 no 199 0.0107770448531258 107 6793154 SGTC_1000 4048-0884 8.67 µM 2.29727717340905 0.0175850120065198 no 200 0.0108014815546173 163 13040088 SGTC_1835 st008666 49.2 µM 2.29231191380231 0.0177839254249479 no 201 0.0109438254193432 125 690455 SGTC_1256 0570-0116 285 µM 2.28607240372986 0.0180366055035009 no 202 0.0111250115627988 158 410638 SGTC_2885 9057732 51.95 µM 2.28451882533694 0.0180999942690601 no 203 0.0111705287528639 137 6471414 SGTC_400 oxethazaine 37.5 µM 2.28041045580572 0.0182685388328773 no 204 0.0112916780360705 141 4621 A local anesthetic. SGTC_187 1488-2104 32.728 µM 2.27965341889874 0.0182997415005493 no 205 0.0113141260188424 167 2852859 SGTC_2385 9074692 200 µM 2.27580830748332 0.0184589267218407 no 206 0.0114287426551755 174 17046906 SGTC_172 1112-0046 2.638 µM 2.2746597387396 0.0185067048959605 no 207 0.0114631747335921 150 2802135 YIL048W NEO1 SGTC_370 0180-0345 38.7 µM 2.27366203238012 0.0185482929224797 no 208 0.0114931573205126 127 3989527 SGTC_1220 1838-0075 193 µM 2.26993357629758 0.0187044135395815 no 209 0.0116058067669817 147 5529645 SGTC_480 am 92016 50 µM 2.26897199474948 0.018744858521057 no 210 0.0116350144861286 120 2129 K+ channel blocker. SGTC_951 1171-0579 82.7 µM 2.26117087066071 0.0190757402818415 no 211 0.0118743390789113 271 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_641 4092-0595 30 µM 2.26002979692538 0.0191245523952704 no 212 0.0119097007935116 159 786260 SGTC_948 3448-0295 75.3 µM 2.25922798799058 0.0191589151500175 no 213 0.0119346033521448 179 678569 SGTC_2908 7930301 100 µM 2.25507516610728 0.0193377318011983 no 214 0.0120643055636787 195 2223178 SGTC_1078 idebenone 36.1 µM 2.24748238539209 0.0196683376960082 no 215 0.0123046075346775 234 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1767 st044992 70.3 µM 2.24720995659527 0.019680288465858 no 216 0.0123133060847815 181 9600693 SGTC_1023 4482-3888 16 µM 2.24480749486533 0.0197859456118999 no 217 0.0123902467122742 146 3303168 SGTC_1146 3579-1023 7 µM 2.24095959674493 0.0199561741746958 no 218 0.0125143461285787 175 X1146 SGTC_1202 1988-0068 29.6 µM 2.23138070375903 0.0203853429175715 no 219 0.0128279609658519 187 2850480 SGTC_1462 k081-0014 26.5 µM 2.22835522577863 0.0205225103218161 no 220 0.0129284181672137 94 3270634 SGTC_1870 st057514 26.5 µM 2.22527881870855 0.0206627877512136 no 221 0.0130312632352491 179 5393161 SGTC_160 3453-0671 289.699 µM 2.22392920752146 0.0207245828681567 no 222 0.0130766037990197 195 5322268 SGTC_1049 3226-0134 66 µM 2.20328857916134 0.0216893319265499 no 223 0.0137872077137966 188 5702385 SGTC_712 r015-0009 80.6 µM 2.19788563710338 0.0219480438806287 no 224 0.0139786283403808 137 6813872 YLR060W FRS1 SGTC_715 0868-0130 184 µM 2.18760146325661 0.0224476893530239 no 225 0.0143493225844514 128 2876258 SGTC_3203 9113543 49.47 µM 2.18627107699987 0.022513020076569 no 226 0.0143978894353839 188 17018012 SGTC_423 5-fluorouracil 457 µM 2.18569471177973 0.0225413731375291 no 227 0.014418974025224 181 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1142 3253-1408 9.78 µM 2.17469350158338 0.0230883526159626 no 228 0.0148265460991407 151 256655 SGTC_516 3992-2719 87.3 µM 2.17359255562178 0.0231437016804771 no 229 0.0148678739965884 158 5350887 YDR037W KRS1 SGTC_1307 1187-1599 12.2 µM 2.17253767288457 0.0231968397198302 no 230 0.0149075656345237 169 1538471 SGTC_673 1082-0474 110 µM 2.17138756422995 0.0232548916132471 no 231 0.0149509440753553 261 3098046 SGTC_1415 3966-0071 78.1 µM 2.16214256844543 0.0237259910455468 no 232 0.0153035943655474 134 2893185 SGTC_2098 5376439 882.5 nM 2.152928155469 0.0242034910365582 no 233 0.0156621626601645 171 2844116 SGTC_2183 6420625 130.508 µM 2.14798702280271 0.024462852986321 no 234 0.0158573931971336 271 2897619 SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.1453183926893 0.024603898000085 no 235 0.0159636994564586 206 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1766 st045414 44.774 µM 2.14372288160156 0.0246885509934239 no 236 0.0160275488358118 211 253960 SGTC_2852 9023854 51.95 µM 2.14206614095536 0.0247767111109566 no 237 0.016094080029749 177 19798528 SGTC_1022 4477-0945 21.3 µM 2.13210409934035 0.0253124062475254 no 238 0.0164991448574609 195 4648966 SGTC_2601 securinine 100 µM 2.13070819055606 0.0253882387980427 no 239 0.0165565949501398 192 442872 A GABA receptor antagonist. SGTC_824 1304-0008 100 µM 2.11972869823874 0.0259913579669362 no 240 0.0170144656770459 222 768245 SGTC_2133 5320837 200 µM 2.11439216487407 0.0262888023691806 no 241 0.0172408931535366 183 2841355 SGTC_1135 dihydrocapsaicin 536.708 nM 2.11053129850014 0.0265057665563967 no 242 0.0174063091050351 223 107982 A Capsaicinoid. SGTC_39 0986-0283 58.349 µM 2.09804185938732 0.0272178924253002 no 243 0.0179507238954547 236 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.09509561478172 0.0273881890450783 no 244 0.0180812468467863 197 75037 A free radical scavenger. SGTC_3018 9082602 49.47 µM 2.08845746615028 0.027775140464561 no 245 0.0183782941807711 200 17332089 SGTC_2069 5228469 200 µM 2.06914440447806 0.0289269237859024 no 246 0.0192662689565272 179 2835210 SGTC_3054 9094397 49.47 µM 2.06799642150492 0.0289966185040959 no 247 0.0193201797989123 241 2598354 SGTC_1932 st074806 40.9 µM 2.06754110047536 0.0290242999330478 no 248 0.0193415977712894 217 17251235 SGTC_1635 st007035 42.4 µM 2.06743839635868 0.0290305469063147 no 249 0.0193464316864856 453 3716403 SGTC_3041 9091929 49.47 µM 2.06553911073995 0.029146272388911 no 250 0.0194360094557566 205 25236887 SGTC_91 0417-1751 58.384 µM 2.06324443466816 0.0292866003980339 no 251 0.019544705179585 271 6795624 SGTC_1038 k292-0204 154 µM 2.06213080143099 0.0293549052006255 no 252 0.0195976422927969 185 4454212 SGTC_1189 1431-2119 7.28 µM 2.04792757055483 0.0302377232232481 no 253 0.020283548452549 266 3107275 SGTC_836 0330-0104 1.35 µM 2.03938180515212 0.0307794194920684 no 254 0.0207059684424131 193 46494820 SGTC_1227 3909-8010 46.6 µM 2.03826247036173 0.030850962973159 no 255 0.0207618454860586 208 15982272 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.02755271589103 0.0315424721697316 no 256 0.02130295951721 214 2333 A French combination drug. SGTC_2605 digitonin 300 nM 2.02362466582248 0.0317992891676421 no 257 0.021504392574725 255 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2802 7925815 54.55 µM 2.01922784665828 0.0320888008402371 no 258 0.0217317716453197 248 1262923 SGTC_1161 k007-0610 110 µM 2.01681984283361 0.0322482776433505 no 259 0.0218571587118125 355 5843850 SGTC_1959 st077091 55.8 µM 2.01450942764613 0.032401905733059 no 260 0.021978038033847 259 821356 YKL052C ASK1 SGTC_1879 gemcitabine 100 µM 2.00281048423867 0.0331891092254018 no 261 0.0225988170537736 209 60750 A nucleoside analog which inhibits DNA replication. SGTC_202 3594-0513 34.79 µM 1.99921787512021 0.0334339885146323 no 262 0.022792392666608 156 708429 SGTC_1731 st035964 63 µM 1.99854543991993 0.0334799878887539 no 263 0.0228287793669705 237 6739575 SGTC_730 1436-0052 41.2 µM 1.99535884567198 0.0336986827188089 no 264 0.0230018780393037 173 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3210 9128157 49.47 µM 1.99400316202348 0.0337920785743585 no 265 0.0230758544808521 271 17590849 SGTC_1873 rapamycin 2 nM 1.99290787411653 0.0338676906679899 no 266 0.0231357679715797 287 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1337 1486-1011 40.3 µM 1.9911522178569 0.03398918091954 no 267 0.0232320775712668 186 X1337 SGTC_2948 9070189 9.45 µM 1.97891662131452 0.0348458635818935 no 268 0.0239126972779627 218 6473636 YDL196W YDL196W SGTC_587 k089-0003 57 µM 1.96585658888155 0.035779746774062 no 269 0.0246575894212051 117 9659696 SGTC_1826 st055655 41.6 µM 1.94882302407071 0.0370284818684522 no 270 0.0256582815926118 255 676168 SGTC_1184 1269-1718 139 µM 1.94840249522268 0.037059755903327 no 271 0.0256834107475919 210 5403821 SGTC_2072 5231554 129 µM 1.94085363403598 0.037624833622206 no 272 0.0261380166572882 199 789545 SGTC_1244 0416-0015 52.5 µM 1.93655020119621 0.0379501070527596 no 273 0.0264001751751359 257 96201 SGTC_1881 5652484 16 µM 1.93577249162256 0.0380091340251807 no 274 0.026447785722132 253 2255129 SGTC_339 3091-4833 71.4 µM 1.93551121731475 0.0380289811472139 no 275 0.0264637967483483 191 3240077 SGTC_129 0088-0017 176.636 µM 1.93061173106903 0.0384027280007206 no 276 0.0267655430197653 278 182446 SGTC_3307 9126885 69.2785 µM 1.92958394853882 0.0384815089076353 no 277 0.0268292046244269 282 24824909 SGTC_2382 9035899 200 µM 1.92763749620792 0.0386310680211957 no 278 0.0269501157666441 236 6462679 SGTC_2658 polymyxin b sulfate 77.05 µM 1.92578497325204 0.0387738494599663 no 279 0.0270656142631415 247 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2389 9091542 195.52 µM 1.91594252475022 0.0395396721435437 no 280 0.0276862059415457 274 3626624 YOL127W RPL25 SGTC_2914 7968218 45.32 µM 1.91126560172907 0.0399078629178025 no 281 0.0279852285954164 178 2977111 SGTC_2346 9031566 143.75 µM 1.90139159058467 0.0406943477613846 no 282 0.028625370102341 225 4771086 SGTC_1623 st003709 20.3 µM 1.89161586088514 0.0414853494565551 no 283 0.0292710905375736 352 16192618 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.89100465724218 0.041535215870291 no 284 0.0293118612690034 252 521171 SGTC_126 0417-1624 672.48 µM 1.8905351504686 0.0415735546012113 no 285 0.0293432120381687 333 41912 YDL195W SEC31 SGTC_2197 6588183 93.1375 µM 1.88874697139154 0.0417198353778086 no 286 0.0294628707048573 185 884136 SGTC_2015 5119600 184 µM 1.88487321143552 0.0420381555054522 no 287 0.0297234788152383 260 2828786 SGTC_744 1594-0068 283 µM 1.8829187464449 0.0421995051747337 no 288 0.0298556901437092 308 668392 SGTC_293 4049-0273 38.5 µM 1.88009200928954 0.0424337508643782 no 289 0.0300477696623441 218 1380311 SGTC_1177 0983-0204 23.6 µM 1.87329396340944 0.0430013977719436 no 290 0.0305139015057057 242 766818 SGTC_583 1488-1091 88.9 µM 1.8628722866615 0.0438835199471054 no 291 0.0312401183628859 318 4303273 SGTC_3130 9127414 49.47 µM 1.86105656979472 0.0440386904221027 no 292 0.0313680942259485 225 1494646 SGTC_2466 5983409 37.09 µM 1.85383186648136 0.0446604984825286 no 293 0.0318816089648894 244 2879657 SGTC_2553 4-methylesculetin 85.09 µM 1.84822712816281 0.0451477357611498 no 294 0.0322847462613072 281 5319502 SGTC_119 0121-0043 24.815 µM 1.84652255954324 0.0452967645262989 no 295 0.0324081834213125 471 1092378 SGTC_117 lucigenin 22.078 µM 1.84414825928979 0.0455050064945668 no 296 0.0325807682175479 361 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1425 4048-4433 7.33 µM 1.8437951722092 0.0455360402363735 no 297 0.0326064982875966 286 23734946 SGTC_1475 4092-1048 11.7 µM 1.84374060850189 0.0455408375002784 no 298 0.0326104759344871 301 2881759 SGTC_174 3553-0389 74.3 µM 1.83724057709852 0.0461152369099733 no 299 0.033087193946225 239 738071 SGTC_2555 cholic acid 100 µM 1.83002893130128 0.0467593150531922 no 300 0.0336228063916263 249 6708657 Influences liver metabolism. SGTC_2187 6125751 200 µM 1.82943705115256 0.0468124952341936 no 301 0.0336670806863623 266 874498 SGTC_2765 myclobutanil 7.74 µM 1.82884820548459 0.0468654509015259 no 302 0.0337111755916234 293 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_108 0509-0257 621.132 µM 1.81777548765454 0.0478702105550338 no 303 0.0345492273016634 335 536624 SGTC_755 1995-0008 37.3 µM 1.81470197071876 0.0481521442504457 no 304 0.0347848610244908 256 689533 SGTC_1445 4239-0156 97.7 µM 1.81272943715314 0.0483337836392954 no 305 0.0349367809505802 319 4008346 SGTC_1682 st012968 530 nM 1.81268994278636 0.0483374260395806 no 306 0.0349398282668917 237 24207270 SGTC_662 k832-1615 104 µM 1.81028640789379 0.0485595075857836 no 307 0.0351256918751698 274 5878478 SGTC_1895 st058434 18.3 µM 1.80902807533365 0.0486760997884653 no 308 0.0352233208877583 278 5393175 SGTC_89 0302-0250 142.109 µM 1.80672947435861 0.0488896568765047 no 309 0.0354022348583404 303 4203518 YLR208W SEC13 SGTC_3245 9134821 49.47 µM 1.80174752862736 0.0493550863495192 no 310 0.0357925682860707 297 17014901 SGTC_526 4469-0568 170 µM 1.79759105138172 0.0497460988479028 no 311 0.0361209187351272 298 2901964 SGTC_74 000s-0487 160.283 µM 1.78405155228502 0.0510369616637723 no 312 0.0372076443253773 296 677548 SGTC_2834 9001755 58.44 µM 1.78009000000863 0.051419658010113 no 313 0.0375306164378467 282 2989575 SGTC_2814 7977482 42.97 µM 1.779559830355 0.051471046499295 no 314 0.0375740125642759 386 6456762 SGTC_660 4031-1742 102 µM 1.77881479703739 0.0515433303932051 no 315 0.0376350652204189 340 6738706 SGTC_490 phenamil 164 µM 1.77762298648989 0.0516591288864135 no 316 0.0377328979598048 178 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2732 terfenadine 20 µM 1.77343665149214 0.0520675207797341 no 317 0.038078190119195 223 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_657 3534-0529 86.7 µM 1.77012301309487 0.0523925930763888 no 318 0.0383533253256811 293 1049549 SGTC_2413 inermin 26.06 µM 1.76946661847332 0.0524571770554193 no 319 0.0384080183855656 345 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2396 5342950 42.78 µM 1.76761203197733 0.0526399951072461 no 320 0.0385628925796485 359 1886677 SGTC_739 1486-1183 203 µM 1.7661169759649 0.0527877397999938 no 321 0.0386881129976358 303 4346692 SGTC_1805 st050013 60.3 µM 1.76509448094242 0.0528889742888655 no 322 0.0387739440438285 246 4037144 SGTC_2836 9010338 19.48 µM 1.76251543546986 0.0531450027976917 no 323 0.0389911253949844 304 2994051 SGTC_2587 piperic acid 92.2 µM 1.76054123501042 0.0533416499830119 no 324 0.0391580412019003 288 5370536 SGTC_1427 4048-4900 550 nM 1.75699663109641 0.0536961695650951 no 325 0.0394591917153767 291 24132586 SGTC_2731 amoxapine 43.43 µM 1.75698406844816 0.0536974293504084 no 326 0.0394602623824734 139 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_973 1325-0077 65.9 µM 1.75681904097519 0.0537139805178103 no 327 0.0394743292455578 317 2835149 SGTC_3029 9088683 49.47 µM 1.75309745891236 0.0540883047385099 no 328 0.0397926398278797 286 25236615 SGTC_481 bay k-8644 50 µM 1.74498872326853 0.0549110469062827 no 329 0.0404934159557615 296 2303 A calcium channel antagonist. SGTC_1659 st012954 42.1 µM 1.73303471661339 0.0561419456288665 no 330 0.0415447492311906 266 24207262 SGTC_144 4161-2749 112.381 µM 1.73249968644679 0.0561975420565 no 331 0.0415923164353154 262 797501 YMR168C CEP3 SGTC_1559 coumarin 343 70.1 µM 1.73202411262458 0.0562469966488508 no 332 0.0416346346653389 255 108770 A hepatotoxic, DNA x-linker. SGTC_1607 st000305 50.6 µM 1.72897895588188 0.0565644740891138 no 333 0.0419064307541604 312 5457690 SGTC_2173 5763948 167 µM 1.72603287751712 0.0568729641197491 no 334 0.0421707490479809 315 2867177 SGTC_1376 2910-0861 41.3 µM 1.71606308840034 0.057926758715701 no 335 0.0430752480699758 345 1112859 SGTC_2966 9084041 48.03 µM 1.71576613818002 0.0579583797866922 no 336 0.0431024270670955 314 17741380 SGTC_2519 cryptotanshinone 88.04 µM 1.70924164302466 0.0586565773459127 no 337 0.0437030990292543 269 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_902 1120-0002 2.07 µM 1.69803645086497 0.0598710515258987 no 338 0.0447504411846456 384 3280475 SGTC_921 1561-0023 372 µM 1.6916086975005 0.0605765617294633 no 339 0.0453603035300118 333 24050882 SGTC_1501 4491-0275 38.4 µM 1.69094562479468 0.0606497091167643 no 340 0.0454235941369801 290 5104718 SGTC_669 0108-0021 26.2 µM 1.68584014742244 0.0612152401056989 no 341 0.0459132963338167 476 17201 SGTC_2546 rhodinyl acetate 100 µM 1.68505754901597 0.0613022911697656 no 342 0.04598873442061 330 6708682 SGTC_2376 9072922 81.32 µM 1.68425778843979 0.0613913511312988 no 343 0.046065929690822 370 17087968 SGTC_1520 flindersine 88 µM 1.68354678229096 0.0614706123937544 no 344 0.0461346454888855 341 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2242 6630449 61.2675 µM 1.67872990555776 0.0620096930225026 no 345 0.0466023474149857 311 691249 YDR170C SEC7 SGTC_1669 st015249 58.4 µM 1.67785007370121 0.0621085566376001 no 346 0.0466881855779903 274 722793 SGTC_2007 4011539 71.82 µM 1.66803240605675 0.0632200926985566 no 347 0.0476546469751494 367 45595301 SGTC_369 0957-0393 4.5 µM 1.66781414190084 0.0632449789772555 no 348 0.0476763138263903 328 6997992 SGTC_1967 st070177 51.4 µM 1.66557760532024 0.0635004265450793 no 349 0.0478987873386963 299 5729214 SGTC_1810 st050138 53 µM 1.65585899378769 0.0646197802536513 no 350 0.048875188756725 275 3444541 SGTC_798 1287-0182 476 µM 1.65559215444802 0.0646507286118786 no 351 0.0489022200346381 390 1649755 SGTC_2470 5664817 21.68 µM 1.65499136705721 0.0647204508170071 no 352 0.0489631245428995 297 2859561 SGTC_3182 9108849 49.47 µM 1.64401461933614 0.0660046224439477 no 353 0.050086591313731 395 17133045 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.64240001343406 0.0661951696535584 no 354 0.0502535660784544 399 442882 SGTC_1565 sinapyl alcohol 95.1 µM 1.64123526631358 0.0663328912608633 no 355 0.0503742938585475 333 5280507 A phenol propionate derived from cinnamic acid. SGTC_2787 5284540 71.43 µM 1.64036911251505 0.0664354504785069 no 356 0.0504642217458138 346 736958 SGTC_1474 0330-0125 5.35 µM 1.63894913846315 0.0666038517985586 no 357 0.0506119263648086 339 X1474 SGTC_543 3844-1095 191 µM 1.63853746374862 0.0666527359428958 no 358 0.0506548127830592 387 4230703 SGTC_346 4513-0042 7.16 µM 1.63731602147192 0.0667979390246256 no 359 0.0507822274928355 381 2827372 SGTC_2421 5690543 90.72 µM 1.63687170857993 0.0668508188891229 no 360 0.050828639228224 350 3397993 SGTC_924 2046-0044 21.3 µM 1.63462863750435 0.0671182724222476 no 361 0.0510634602760699 348 3623589 SGTC_2026 5148700 152 µM 1.63435783900283 0.0671506170951104 no 362 0.0510918677536746 344 79838 SGTC_2691 st077356 60.2 µM 1.63077633721457 0.0675795329459242 no 363 0.0514687610800874 377 2839272 SGTC_1325 1431-0015 227 µM 1.6281248780392 0.0678984295138124 no 364 0.0517492047010365 313 1103340 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.62325208594843 0.0684875191446997 no 365 0.0522677637722357 327 2374 Ca(2+)-ATPase inhibitor. SGTC_85 0868-0259 160.055 µM 1.61363857690983 0.0696612848241621 no 366 0.0533029220682599 321 83173 SGTC_2938 9059746 27.26 µM 1.61221355745132 0.0698365833502325 no 367 0.0534577380351176 340 6471769 SGTC_466 geldanamycin 89.2 µM 1.61176153251953 0.0698922599882729 no 368 0.0535069209790311 245 5288382 HSP90 inhibitor. SGTC_2436 5633522 8.09 µM 1.61143027756636 0.0699330828771708 no 369 0.0535429862047162 381 5724242 SGTC_2742 clothiapine 36.27 µM 1.60719899257746 0.0704561493528027 no 370 0.0540053614872956 291 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2582 agaric acid 100 µM 1.60447308170791 0.0707947128847435 no 371 0.0543049066445851 765 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3002 9075603 71.4286 µM 1.60010640167924 0.0713396663507443 no 372 0.0547874905410662 369 20105405 SGTC_1776 st049249 45.9 µM 1.59805132320867 0.0715972479723988 no 373 0.0550157777325391 403 1822314 SGTC_1982 st072467 71.9 µM 1.59579806365866 0.0718804888808084 no 374 0.0552669428828768 443 3163533 SGTC_984 1492-0255 2.91 µM 1.58899038839936 0.0727414530098138 no 375 0.0560312813539231 347 1585198 SGTC_2138 5575593 77.673 µM 1.58793193679994 0.0728760213476363 no 376 0.0561508654036638 295 762213 SGTC_27 0485-0001 32.618 µM 1.5866176987745 0.073043374723376 no 377 0.0562996282244524 259 2054479 SGTC_1240 0356-0016 42.1 µM 1.58126564419538 0.0737279374214627 no 378 0.0569086557459451 388 4305613 SGTC_2200 6600604 21.907 µM 1.57417441140263 0.0746424923196075 no 379 0.0577235666817403 425 2904777 SGTC_2172 5754775 163.918 µM 1.57292548134176 0.0748044594760923 no 380 0.057868037040717 376 2263357 SGTC_950 1165-0508 94.1 µM 1.57181917138136 0.0749481548247344 no 381 0.0579962470442183 387 6148369 SGTC_1358 1509-0022 2.48 µM 1.56511235084064 0.0758237949709805 no 382 0.0587782840490298 383 3258434 SGTC_2409 alverine citrate 63.97 µM 1.56418839421843 0.0759450345691384 no 383 0.0588866659650884 407 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1741 st038134 10.228 µM 1.56201815096567 0.0762303897171333 no 384 0.0591418564760286 432 1272587 SGTC_2984 9022109 38.96 µM 1.55838305321417 0.0767101787747961 no 385 0.0595712357334941 302 6459207 SGTC_288 1315-0019 35.1 µM 1.55672178279342 0.0769302094701468 no 386 0.0597682773121645 394 6811474 SGTC_1217 1183-1422 255 µM 1.55218002119665 0.0775342018236236 no 387 0.0603095775609573 380 2849664 SGTC_139 0099-0334 718.624 µM 1.55161192808889 0.0776100031303798 no 388 0.0603775536665502 470 97690 SGTC_1368 1852-0141 284 µM 1.55091400456863 0.0777032048630736 no 389 0.060461146904155 398 2838987 SGTC_3249 9135183 49.47 µM 1.54897668464274 0.0779623626698901 no 390 0.0606936624800535 404 4902779 SGTC_2320 7373003 200 µM 1.54472197999674 0.0785338211952242 no 391 0.0612067629706311 388 5415828 SGTC_2080 5212524 12.4 µM 1.54314738076037 0.0787461120929743 no 392 0.061397510463568 354 260183 SGTC_2068 5226020 147 µM 1.54309833823099 0.0787527310893837 no 393 0.0614034589407756 448 1810509 SGTC_2817 7995342 71.43 µM 1.53961098719552 0.0792244809920102 no 394 0.0618276028376963 343 18879975 SGTC_2999 9069765 71.4286 µM 1.53737356566577 0.079528271973862 no 395 0.0621009279266132 408 2097066 SGTC_1289 0976-0073 69.1 µM 1.53454901279643 0.0799130398585058 no 396 0.0624473225767257 405 3391136 SGTC_2185 6113692 200 µM 1.53453829578956 0.0799145024328432 no 397 0.0624486397411461 371 874150 SGTC_2066 5222451 176 µM 1.53376340367838 0.0800203073777791 no 398 0.0625439346030344 473 2281147 SGTC_2699 st077704 54.6 µM 1.53221065359509 0.0802326409321264 no 399 0.0627352302024333 406 645852 SGTC_2302 7771753 200 µM 1.52969204516498 0.0805779576248788 no 400 0.063046486793166 457 2203047 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.52405149660596 0.0813553821751971 no 401 0.0637479238235873 467 676296 Flavone; oxidizing agent. SGTC_691 1548-0686 185 µM 1.52342058974753 0.0814426893142409 no 402 0.0638267570029594 447 46495133 SGTC_3218 9131285 49.47 µM 1.52212043974621 0.0816228315342683 no 403 0.0639894526829397 487 17156417 SGTC_2504 purpurogallin 52.29 µM 1.51992795417634 0.0819272914821267 no 404 0.0642645419269373 372 5281571 An antioxidant. SGTC_833 3852-0053 558 µM 1.51260749010121 0.0829500490220178 no 405 0.0651896952403769 454 3123681 SGTC_1775 st081588 35.1725 µM 1.50847688194804 0.0835313678172665 no 406 0.0657162595437694 451 1426443 YGL099W LSG1 SGTC_1714 st033236 13.627 µM 1.50600755607897 0.0838803460852017 no 407 0.0660326169799162 447 2916566 SGTC_311 1315-0136 58 µM 1.50265116145694 0.084356443738115 no 408 0.0664645114592062 400 6759207 SGTC_3189 9110682 49.47 µM 1.49620418968854 0.0852766170360868 no 409 0.0673002265526744 419 17122418 SGTC_646 4092-0839 27.3 µM 1.49307272190445 0.0857262742502853 no 410 0.0677090760161856 407 877796 SGTC_3123 9126162 49.47 µM 1.49302964895676 0.0857324715803021 no 411 0.0677147130368891 408 25239884 SGTC_3077 9117319 49.47 µM 1.48245938606103 0.087263480290736 no 412 0.0691090512623093 362 17154678 SGTC_115 0527-0192 112.043 µM 1.47892371036778 0.0877801209168117 no 413 0.06958035278336 530 4233931 SGTC_2846 9008642 19.48 µM 1.47708281586891 0.088050018037425 no 414 0.0698267196331253 408 2992898 SGTC_3220 9131269 49.47 µM 1.4729621859313 0.0886563933265762 no 415 0.070380616183774 389 17722206 SGTC_1362 1611-0397 101 µM 1.4687134470493 0.0892848718019121 no 416 0.0709552643018221 435 27816 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.46810005701735 0.0893758783147925 no 417 0.0710385230570527 436 4213774 SGTC_2662 daunorubicin 22.37 µM 1.46656076977884 0.0896045607524236 no 418 0.0712477892444954 389 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3119 9125183 49.47 µM 1.46515499592414 0.0898137877845244 no 419 0.0714393174550604 305 22695334 SGTC_383 2324-0395 7.37 µM 1.46270690045316 0.0901790142666584 no 420 0.0717737985913305 462 3146421 SGTC_559 1550-0661 158 µM 1.45671905003499 0.0910769772384658 no 421 0.0725969745142896 442 5830875 SGTC_2515 chrysin 20.77 µM 1.45623708648919 0.0911495418540498 no 422 0.0726635452965211 434 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3187 9109394 49.47 µM 1.45114472057113 0.09191887176646 no 423 0.0733697829966682 476 17098090 SGTC_785 1270-0111 65.3 µM 1.44923491120364 0.0922086330463841 no 424 0.0736359955578458 461 6741994 SGTC_2985 9022375 71.43 µM 1.44872893616232 0.0922855140809005 no 425 0.0737066481298648 460 4939335 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.44692261172101 0.0925603654086996 no 426 0.0739592996741765 488 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3279 9140807 49.47 µM 1.44513143295566 0.0928335096656998 no 427 0.0742104856861447 432 45595718 SGTC_3196 9111891 49.47 µM 1.44351783352671 0.0930800840089428 no 428 0.0744373262466951 410 18891510 SGTC_1569 carminic acid 40.6 µM 1.44333273977493 0.0931083991279932 no 429 0.074463380620444 454 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2994 9053520 71.4286 µM 1.44254225054228 0.0932293975875619 no 430 0.0745747307128 455 4647384 SGTC_274 sirtinol 40.1 µM 1.44250988712984 0.0932343538590316 no 431 0.0745792922025793 455 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1335 1486-0900 202 µM 1.44094597832476 0.0934740896236044 no 432 0.0747999725960381 489 X1335 SGTC_3280 9140961 49.47 µM 1.43593257132283 0.0942456771501271 no 433 0.075510764578069 423 4901226 SGTC_2210 7115885 190.385 µM 1.43333267590773 0.0946476586938954 no 434 0.0758813940667116 477 2927039 SGTC_82 0054-0107 293.755 µM 1.43040005910028 0.0951025988999469 no 435 0.0763011156555363 416 3104697 SGTC_2359 9039622 200 µM 1.42729791639472 0.0955855885773497 no 436 0.0767470204734993 474 6463596 SGTC_2868 9035608 32.47 µM 1.42656329720235 0.0957002293685668 no 437 0.0768529049093029 489 6462614 SGTC_2005 4024620 188 µM 1.42289039454841 0.0962749206675113 no 438 0.0773839655922982 446 236743 SGTC_2499 avocadenofuran 51.48 µM 1.42260046209273 0.0963203935718632 no 439 0.0774260049882659 492 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1384 3089-0840 101 µM 1.4212235454079 0.0965365642010401 no 440 0.0776258908807936 419 1069836 SGTC_2311 7694451 200 µM 1.42063983390542 0.0966283121616563 no 441 0.0777107459646837 462 2163142 SGTC_3125 9127534 49.47 µM 1.4161852842688 0.0973305899912103 no 442 0.0783606316330901 351 1639235 SGTC_1886 st057356 49.9 µM 1.41560196810041 0.097422828722277 no 443 0.0784460373851545 448 24207747 SGTC_3250 9135583 49.47 µM 1.41512841483524 0.097497757988323 no 444 0.0785154241792284 433 7699353 SGTC_2225 6654152 15.4 µM 1.4146043357593 0.0975807311022006 no 445 0.0785922684279537 377 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1036 k216-0215 33.5 µM 1.41436966899898 0.0976179007329115 no 446 0.0786266954298632 540 622330 SGTC_2426 5582046 32.21 µM 1.41138837761759 0.0980910212510571 no 447 0.0790650640274933 492 2251934 SGTC_991 3996-0057 64.7 µM 1.40551794292853 0.0990275457736755 no 448 0.0799336587895462 475 715343 SGTC_994 3910-0338 138 µM 1.40520960017235 0.0990769166051011 no 449 0.0799794801246414 510 3479481 SGTC_1094 duloxetine 25.4 µM 1.40486292791312 0.0991324461273288 no 450 0.0800310211374398 480 60834 A selective serotonin reuptake inhibitor. SGTC_787 4152-0075 138 µM 1.40465540817173 0.0991656972646089 no 451 0.0800618858574025 470 9566539 SGTC_291 SEC14.278 35.5 µM 1.39726345567117 0.100355443840143 no 452 0.0811671804533724 491 1068044 SGTC_808 0711-0032 135 µM 1.396089339222 0.100545374465363 no 453 0.0813437968671987 462 4252555 SGTC_3197 9113331 49.47 µM 1.39593049236164 0.100571090409943 no 454 0.0813677136451984 497 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1155 4088-0394 48.2 µM 1.39365151055432 0.100940566392732 no 455 0.0817114327434655 496 2326248 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.39169677755921 0.101258261672876 no 456 0.0820071192721114 406 61125 An anti-inflammatory. SGTC_1431 4049-0260 9.09 µM 1.38710721321785 0.102007048171004 no 457 0.0827045364148251 476 3854841 SGTC_1059 3448-6867 171 µM 1.38510487582766 0.102334988499829 no 458 0.0830102006135578 479 3934407 SGTC_1198 1612-1005 86.7 µM 1.38362827175559 0.102577315606527 no 459 0.0832361534590175 498 6998509 SGTC_772 k072-0172 35.3 µM 1.38179080634095 0.102879446230258 no 460 0.0835179713735769 444 5861980 SGTC_3255 9139072 49.47 µM 1.3816858922938 0.102896716521046 no 461 0.0835340839876896 487 17646060 SGTC_203 k066-0004 30.888 µM 1.3773562597369 0.103611271556234 no 462 0.0842010645677478 594 6795412 SGTC_1716 st033144 30.6155 µM 1.37406592697687 0.10415670537098 no 463 0.0847106081278291 527 674617 SGTC_2823 7987624 58.44 µM 1.37190708352597 0.104515702874283 no 464 0.085046182492378 529 2239440 SGTC_2716 st080858 38.6235 µM 1.36936237345416 0.104940016824442 no 465 0.0854430148530455 473 5296050 SGTC_2955 9076254 12.21 µM 1.36507019808505 0.105658532532807 no 466 0.0861154938707008 452 16459619 SGTC_2713 st079149 53.4 µM 1.36356466531056 0.105911401400511 no 467 0.0863523096741805 535 3103253 SGTC_2621 lithochol-11-enic acid 100 µM 1.36343650434045 0.105932947464899 no 468 0.0863724914820431 549 6708711 SGTC_1315 1237-0019 3.69 µM 1.36304528811864 0.10599873723597 no 469 0.0864341190317332 514 825140 SGTC_363 0455-0021 3.06 µM 1.36187836268884 0.106195151283819 no 470 0.0866181378699042 531 4597466 SGTC_792 4534-1957 155 µM 1.35895128859629 0.106688985741133 no 471 0.0870810124450772 487 1717904 SGTC_2926 9010726 65.15 µM 1.35767144485994 0.106905431567707 no 472 0.0872839807652211 519 2994293 SGTC_3322 9139058 2.11 µM 1.35578064032907 0.107225781898495 no 473 0.0875844864014264 501 4908926 YPR165W RHO1 SGTC_2235 salicylic acid 500 µM 1.35429343759052 0.107478237709797 no 474 0.087821389486364 471 338 A COX inhibitor and kinase inhibitor. SGTC_3070 9117005 49.47 µM 1.35367289468878 0.107583702746808 no 475 0.0879203797022608 414 8779016 SGTC_3294 9122953 26.2835 µM 1.352260034832 0.107824104999178 no 476 0.0881460722364775 523 16459826 SGTC_3332 9141069 11.198 µM 1.35117990882944 0.108008152407739 no 477 0.0883189044134267 450 17332883 SGTC_297 0986-0032 24 µM 1.35052448722745 0.108119942786937 no 478 0.0884239022081 456 2847425 SGTC_697 0508-1955 564 µM 1.34979445453692 0.108244557055082 no 479 0.0885409620766982 559 6243113 SGTC_746 1095-0025 46.6 µM 1.34121651449524 0.109716533002671 no 480 0.0899250830241872 550 6749286 SGTC_3001 9076041 71.4286 µM 1.33808954285016 0.110256679641786 no 481 0.0904336245937757 507 16004211 SGTC_965 1291-5240 308 µM 1.3380126902626 0.110269978969179 no 482 0.0904461500141774 529 2834598 SGTC_1037 k284-1091 78.7 µM 1.33777499168737 0.110311119949628 no 483 0.0904848982366915 456 3334711 SGTC_462 ag-879 158 µM 1.33455130280161 0.110870164752831 no 484 0.0910116226244413 557 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1418 3966-3099 2.4 µM 1.33389188909048 0.110984768398244 no 485 0.0911196450631266 548 740335 SGTC_2061 5245884 80.95 µM 1.3329948159146 0.11114081257021 no 486 0.091266752523537 541 573863 SGTC_1729 st035615 45.989 µM 1.32875644203071 0.11188019426305 no 487 0.0919641684918284 524 17385451 SGTC_547 1120-0019 610 nM 1.3277048710747 0.112064183565162 no 488 0.0921378118685853 535 3676939 SGTC_1019 4262-0212 3.4 µM 1.32654754209227 0.112266926861037 no 489 0.0923291992507336 619 4677213 SGTC_121 0557-0495 61.343 µM 1.32103419938753 0.113236364473182 no 490 0.093244980627668 701 3104427 SGTC_767 0929-0023 86 µM 1.31878106084776 0.113634258801291 no 491 0.0936211588315263 629 1204563 SGTC_2869 9037858 32.47 µM 1.3176272520981 0.113838401800451 no 492 0.0938142290818082 463 27187042 SGTC_618 k072-0232 33.2 µM 1.31710824704971 0.113930314364168 no 493 0.0939011715132023 506 5872756 YGL099W LSG1 SGTC_2884 9058502 51.95 µM 1.30960609472072 0.115264808494287 no 494 0.0951645627890686 555 6471554 SGTC_1809 st050081 57.6 µM 1.30562197388449 0.115978010182881 no 495 0.0958405719675272 529 5036894 SGTC_2627 acetyl isogambogic acid 100 µM 1.30428991105608 0.116217161547455 no 496 0.096067376947991 516 6857789 A caspase activator and apoptosis inducer. SGTC_858 0438-0351 2.77 µM 1.30386618427419 0.116293308478122 no 497 0.0961396058709034 562 2799119 SGTC_771 0250-0039 27.3 µM 1.30311037541209 0.116429220963493 no 498 0.096268540967667 542 3005115 SGTC_913 3487-1245 167 µM 1.30115383734214 0.116781576507079 no 499 0.096602901372019 556 4016153 SGTC_810 3825-7150 143 µM 1.29617228071425 0.117682122463436 no 500 0.0974580685702245 561 22330411 YGL099W LSG1 SGTC_1194 1488-0194 225 µM 1.29369611177371 0.118131578617606 no 501 0.097885204464481 588 1391452 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.28903048146619 0.11898174561406 no 502 0.0986937449144952 537 4330530 SGTC_263 alizarin 107.927 µM 1.28863144423425 0.119054657873499 no 503 0.0987631231751548 631 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2206 7254556 146.969 µM 1.28833010636328 0.11910973936502 no 504 0.0988155386697124 489 4398905 SGTC_860 0443-0016 25.1 µM 1.28255213416802 0.120169374983756 no 505 0.0998245144397776 548 5337942 SGTC_585 0kpi-0023 191 µM 1.27976878950008 0.120682182655879 no 506 0.100313231743265 514 64601 SGTC_724 3910-0327 137 µM 1.27908466266851 0.12080846274833 no 507 0.100433621979141 573 2885483 SGTC_1429 4049-0205 9.46 µM 1.27903017079437 0.120818525171452 no 508 0.100443215798951 592 22774478 SGTC_1134 3477-0009 42.5 µM 1.27837003316193 0.120940472485076 no 509 0.100559492516939 618 3973534 SGTC_1670 st016595 4.04 µM 1.27729962989884 0.121138392254927 no 510 0.100748242124035 565 597879 SGTC_3284 9108171 64.8615 µM 1.26908363348479 0.122665134141554 no 511 0.102205618452946 526 8687505 SGTC_1968 st069590 43.6 µM 1.26543249482812 0.123347922879526 no 512 0.102858166427974 553 6384066 SGTC_2478 5763493 32.33 µM 1.26540315210524 0.123353420940375 no 513 0.102863422925341 589 1365576 YLR208W SEC13 SGTC_591 4299-0174 154 µM 1.26445412293266 0.123531336837378 no 514 0.103033538626191 567 5509088 SGTC_914 3820-6779 408 µM 1.26305150237963 0.123794617156882 no 515 0.103285335704799 549 2893481 SGTC_1790 st045711 43.5 µM 1.25760614741435 0.124820464780764 no 516 0.104267114520761 573 585119 SGTC_2144 5628481 200 µM 1.25546444299159 0.125225562425079 no 517 0.104655104050337 522 2818399 SGTC_3232 9132874 49.47 µM 1.25363982050933 0.125571408329344 no 518 0.104986475319651 549 3784940 SGTC_1779 st039427 55 µM 1.25066732789519 0.126136252209168 no 519 0.105527937668604 678 1124498 SGTC_2790 5423970 71.43 µM 1.24966019708496 0.126328031971223 no 520 0.105711851540273 624 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_197 4544-0043 41.561 µM 1.24908515397124 0.126437623856546 no 521 0.105816965012206 624 896523 SGTC_1250 0485-0349 40.2 µM 1.2420687140595 0.127780155238114 no 522 0.107105605275541 562 6842794 YDL195W SEC31 SGTC_1550 gossypolone 36.6 µM 1.23930832261322 0.128311036751439 no 523 0.107615668871177 610 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2513 baicalein 25.65 µM 1.23916336240806 0.128338957918055 no 524 0.107642502824165 590 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3118 9124250 49.47 µM 1.23819629754938 0.128525334767724 no 525 0.107821642030439 532 1504786 SGTC_1158 4092-0494 91.8 µM 1.2364062854532 0.128870808982783 no 526 0.108153790461712 625 1148199 SGTC_2769 toremifene 3.73 µM 1.23633072083714 0.128885407189171 no 527 0.108167828154606 558 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2450 5739737 12.93 µM 1.2358738515699 0.128973693457855 no 528 0.108252729023116 571 2262825 SGTC_1763 st044482 94.5 µM 1.23026682090682 0.130060622956805 no 529 0.109298602299226 611 88505 SGTC_515 4092-1064 102 µM 1.22974058680225 0.130162958526477 no 530 0.10939713151356 672 717353 SGTC_344 k064-0035 6.43 µM 1.22755939420504 0.130587724215633 no 531 0.109806206400676 582 5088750 SGTC_872 0588-0139 234 µM 1.22725433702146 0.13064720739644 no 532 0.10986350618777 606 2047100 SGTC_937 3122-0005 46.7 µM 1.22071350305103 0.131927114526541 no 533 0.111097256681895 639 759535 SGTC_525 k781-2675 26.7 µM 1.2205921099727 0.131950950127111 no 534 0.111120247586636 631 3651118 YDL195W SEC31 SGTC_2115 tiliquinol 12.7705 µM 1.21640243958896 0.132775415001491 no 535 0.111915827547695 577 71208 A bioactive hydroxyquinoline. SGTC_2342 7990637 118.86 µM 1.21633802295507 0.132788118869278 no 536 0.111928091387596 626 2033102 YER133W GLC7 SGTC_1490 4089-0339 670 nM 1.216303800366 0.13279486838649 no 537 0.111934607181831 576 742542 SGTC_1324 1418-0026 34.4 µM 1.21302727396276 0.133442172511235 no 538 0.11255969654006 629 1372513 SGTC_2842 9000675 19.48 µM 1.21279029304767 0.133489074013826 no 539 0.112605003797144 561 2989072 SGTC_3094 9117742 49.47 µM 1.20964101640557 0.134113432009239 no 540 0.113208336051175 650 17149698 SGTC_1316 1272-0050 65.9 µM 1.20956748718902 0.134128033428288 no 541 0.113222450133922 610 7340392 SGTC_1965 Pectolinarigenin 58.4 µM 1.20455928519974 0.135125132388991 no 542 0.114186741195893 619 5320438 An anti-inflammatory. SGTC_1708 st033234 31.827 µM 1.20363178703522 0.135310347339972 no 543 0.114365963914133 655 674664 SGTC_3348 9149464 3.537 µM 1.20072975843274 0.135890986045014 no 544 0.114928023352989 623 1951442 SGTC_1677 st019204 53.9 µM 1.19938058494649 0.136161509184558 no 545 0.11518999669333 596 3945625 SGTC_1089 terbinafine 2.25 µM 1.19819756955446 0.136399019005699 no 546 0.115420055680346 604 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1355 1499-0035 1.68 µM 1.19760998026665 0.136517092512754 no 547 0.115534444456066 594 1548538 SGTC_1268 0828-0275 2.46 µM 1.19581947678188 0.13687731735666 no 548 0.115883506816515 644 745337 SGTC_2157 5649910 96.377 µM 1.19061580236881 0.137927910863964 no 549 0.116902222572414 644 2858091 SGTC_1327 1436-0082 2.18 µM 1.18956210413487 0.138141314712874 no 550 0.117109273959713 616 15992205 SGTC_208 k072-0098 12.366 µM 1.18666549509941 0.138729120090437 no 551 0.117679795225307 723 5948901 SGTC_947 3447-0010 211 µM 1.18203126100991 0.139673078255723 no 552 0.118596648548156 633 748350 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.18044872582511 0.139996426606377 no 553 0.118910896061508 579 17037758 SGTC_2113 5491891 107.031 µM 1.17991127123854 0.140106356563139 no 554 0.119017753257202 639 789979 SGTC_3151 9099821 49.47 µM 1.1785596352462 0.140383076803764 no 555 0.119286786339176 610 17174189 SGTC_834 0312-0008 75.7 µM 1.16945201854208 0.142257350518298 no 556 0.121110781059922 676 6385573 YIL048W NEO1 SGTC_904 1141-0088 396 µM 1.16799615894235 0.142558517035839 no 557 0.121404157128539 622 1378119 SGTC_2291 7917025 104.35 µM 1.16660490679631 0.142846721149652 no 558 0.121684980436463 657 2964612 SGTC_1724 st037281 8.293 µM 1.16648329110063 0.142871933089598 no 559 0.121709550160066 654 574124 YDL195W SEC31 SGTC_1989 st071868 50.2 µM 1.16471685562746 0.143238468863536 no 560 0.122066811902769 657 16414057 SGTC_2012 4023501 200 µM 1.16276341994203 0.14364454613228 no 561 0.122462751219998 602 3477460 SGTC_2479 5617353 43.85 µM 1.16138308126725 0.143931956883693 no 562 0.122743073106987 657 2731746 SGTC_46 0329-0187a 2.197 µM 1.15854037388747 0.144525079736552 no 563 0.123321792753966 745 46494817 SGTC_3169 9102970 49.47 µM 1.15819026981687 0.144598241695034 no 564 0.123393199104895 644 17027839 SGTC_1511 0906-3109 28.5 µM 1.15801823070472 0.144634202198562 no 565 0.123428298383831 752 2882180 SGTC_2625 euphol 100 µM 1.15558026846841 0.14514444522524 no 566 0.123926441351217 706 6708538 A triterpene alcohol. SGTC_1444 4112-3581 28 µM 1.15436977227091 0.145398240444703 no 567 0.1241743012032 663 2877249 SGTC_2087 5276107 200 µM 1.15368077977154 0.145542829311806 no 568 0.124315533310668 654 144405 SGTC_2449 5812982 45.77 µM 1.15255041397557 0.145780252168187 no 569 0.124547482947861 613 776185 SGTC_3238 9133470 49.47 µM 1.15202049966749 0.145891645335175 no 570 0.124656324796015 652 3534688 SGTC_1288 0973-0013 65.5 µM 1.14531662212398 0.147305804786159 no 571 0.126039011412914 685 4315430 SGTC_2657 nystatin 74.44 µM 1.14171304468425 0.148069750904587 no 572 0.12678665838971 700 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_919 tnp00227 403.569 nM 1.14021989185224 0.148387069775475 no 573 0.127097351118045 708 1269246 A methoxyflavone. YNL221C POP1 SGTC_957 1187-1561 14.1 µM 1.13988836999326 0.148457585132907 no 574 0.127166405442412 681 1538454 SGTC_887 0885-0007 9.62 µM 1.13801069587121 0.148857392991907 no 575 0.127558008066647 691 5719458 SGTC_2937 9044753 11.33 µM 1.13666160293777 0.149145095337056 no 576 0.127839888356048 704 6465530 YGL099W LSG1 SGTC_613 3914-0030 117 µM 1.13527687353611 0.149440783345706 no 577 0.128129664427285 426 1145395 SGTC_3085 9117376 49.47 µM 1.1282586341349 0.150945436312732 no 578 0.129605353882739 671 16480349 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.12711897725581 0.151190717719897 no 579 0.129846090382435 667 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2704 st078022 71.1 µM 1.1260843533627 0.151413623016136 no 580 0.130064908106713 682 54697681 SGTC_812 4251-0442 148 µM 1.12419212971505 0.151821859565308 no 581 0.130465763771696 666 5723007 SGTC_1404 3909-7820 48.3 µM 1.12321439880832 0.152033085790178 no 582 0.130673224373306 668 23741373 SGTC_1053 3366-3204 134 µM 1.12259986410838 0.152165947978438 no 583 0.130803736566123 672 3632071 YPR165W RHO1 SGTC_2936 9038235 15.59 µM 1.12250552748582 0.152186350347281 no 584 0.130823779339645 657 4749415 SGTC_1911 st060208 74.3 µM 1.12232897748495 0.152224538047126 no 585 0.130861294883508 720 688783 SGTC_492 tmb-8 126 µM 1.12090896351577 0.152531917899006 no 586 0.131163307538058 513 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_544 k015-0020 52.4 µM 1.11504946722512 0.15380463268139 no 587 0.132414612159167 675 3008304 SGTC_2881 9058953 51.95 µM 1.11375552120912 0.154086629650527 no 588 0.132692041640508 719 17122249 SGTC_399 oxolinic acid 75 µM 1.11128283070824 0.154626467842783 no 589 0.133223313665039 679 4628 A DNA gyrase inhibitor. SGTC_800 3448-7362 155 µM 1.11099804214935 0.154688723096621 no 590 0.133284596019078 931 15991913 SGTC_1850 st056238 17 µM 1.11027380642997 0.154847116837981 no 591 0.133440528377348 739 5393177 SGTC_1935 st074532 41.6 µM 1.10942744212713 0.155032356384691 no 592 0.133622914711885 786 2829742 SGTC_1699 st031318 29.054 µM 1.10515845830307 0.155968917209643 no 593 0.134545466854309 706 5340658 SGTC_2321 7390090 138.78 µM 1.10500761858454 0.156002077598361 no 594 0.134578143970179 620 649046 SGTC_2317 5986382 200 µM 1.10092836931105 0.156900615891872 no 595 0.135463916932857 737 877883 SGTC_3184 9108758 49.47 µM 1.09962034473598 0.157189454674751 no 596 0.13574878694303 712 902885 SGTC_1285 0929-0069 65.5 µM 1.09955874922184 0.157203064848305 no 597 0.135762211718646 700 1206237 SGTC_2669 eugenol 100 µM 1.09897684964014 0.157331679888467 no 598 0.135889081918461 649 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_615 k087-0205 167 µM 1.098811536954 0.157368230933241 no 599 0.13592513945829 673 9642773 SGTC_3092 9117248 49.47 µM 1.09801002988987 0.157545525263355 no 600 0.136100054806678 769 17141857 SGTC_352 k048-0007 5.11 µM 1.09767123203518 0.157620507208721 no 601 0.136174038009087 763 6811911 SGTC_2956 9076196 2.52 µM 1.09591022388235 0.158010627002963 no 602 0.136559032213498 701 16423868 SGTC_2887 9044784 58.44 µM 1.09455204288823 0.158311940274578 no 603 0.136856467727999 770 6465546 SGTC_2557 derrustone 83.84 µM 1.09411005477147 0.158410076855365 no 604 0.136953356558385 720 629853 An antioxidant. SGTC_395 anisomycin 6.25 µM 1.08651767557826 0.160102075674596 no 605 0.138625012579339 646 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2219 9098279 200 µM 1.08184353045366 0.16114958661284 no 606 0.139661030168349 710 902349 SGTC_128 0906-2981 13.371 µM 1.07895220784334 0.161799787220118 no 607 0.140304516685386 657 6740226 SGTC_797 k781-0471 270 µM 1.077588001835 0.162107162606469 no 608 0.140608829488322 755 23738129 SGTC_2130 NSC 7 2.4545 µM 1.07627668396273 0.162402979736744 no 609 0.140901766545061 775 21448 SGTC_376 3970-0862 59.1 µM 1.07543940908037 0.162592042283155 no 610 0.141089022913776 740 3135186 SGTC_2721 ifenprodil 61.44 µM 1.0745979528464 0.16278219322106 no 611 0.141277384395524 724 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2294 7971431 200 µM 1.07090896530174 0.163617530884055 no 612 0.142105182162333 652 5741572 SGTC_471 1-acyl-paf 4 µM 1.06794293502641 0.164291176350219 no 613 0.14277312681721 718 16759367 SGTC_1308 1187-1617 41.4 µM 1.06778039736334 0.164328143843651 no 614 0.142809791242455 767 2882570 SGTC_1347 1493-0251 600 nM 1.06703791452625 0.164497082390422 no 615 0.142977357706407 789 3986378 SGTC_828 2074-0507 139 µM 1.06547869374188 0.16485222116735 no 616 0.14332968113091 751 X828 SGTC_3009 9080819 71.4286 µM 1.06313041642693 0.165388017263367 no 617 0.143861406262117 734 17027216 SGTC_960 1222-0186 7.7 µM 1.06026352382818 0.166043669160661 no 618 0.144512364367674 763 3126296 SGTC_2682 pyrogallin 40.03 µM 1.05979188129286 0.166151693404767 no 619 0.144619645571589 787 822798 An ATP competetive kinase inhibitor. SGTC_3016 9080866 49.47 µM 1.05731213080875 0.166720398094599 no 620 0.145184579365732 761 17066299 SGTC_47 0149-0135 24.25 µM 1.05686369571152 0.166823375919135 no 621 0.145286899656587 704 5239155 SGTC_2124 5246320 200 µM 1.04969202936263 0.168475838040466 no 622 0.146929864772172 728 579342 SGTC_2427 5545055 42.75 µM 1.049440665149 0.168533946485034 no 623 0.146987675227429 814 5372858 SGTC_1701 st028638 40.4 µM 1.04923675975705 0.168581093228925 no 624 0.147034581983678 775 3490878 SGTC_1773 st048542 73.5835 µM 1.04843700246628 0.16876609392047 no 625 0.147218656446128 732 3237138 SGTC_1573 oleylamine 1.06 µM 1.04307398593301 0.170010041496376 no 626 0.148457013946368 745 5356789 An amine of the fatty acid oleic acid. SGTC_2724 maprotiline 69.64 µM 1.04304840702788 0.170015988551333 no 627 0.148462936934836 780 4011 A tricyclic antidepressant. SGTC_3074 9116018 49.47 µM 1.03965028513677 0.170807231920503 no 628 0.149251202819579 717 17027303 SGTC_2461 5755302 26.15 µM 1.03633556561051 0.171581321996439 no 629 0.150022809653071 795 2788904 SGTC_422 cantharidin 155 µM 1.03496712899487 0.171901547171322 no 630 0.150342131279001 759 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1150 3909-7983 10.9 µM 1.03475880334726 0.171950330496756 no 631 0.150390783295481 769 23965914 SGTC_2675 theaflavin digallate 100 µM 1.03074894792072 0.172891034742591 no 632 0.151329282204921 790 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2596 sinensetin 100 µM 1.02989479722271 0.173091839722795 no 633 0.151529696666005 716 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2085 5307070 144.047 µM 1.02827983693278 0.173471911622704 no 634 0.15190910642039 722 2840351 SGTC_3340 9146634 11.102 µM 1.02789522055118 0.173562507200717 no 635 0.151999559016165 774 4907387 SGTC_1581 himbacine 57.9 µM 1.02780918399043 0.173582777051355 no 636 0.152019797657669 776 5281825 An alkaloid muscarinic receptor antagonist. SGTC_385 1494-0393 12.4 µM 1.02708940389341 0.173752413216742 no 637 0.15218918383596 796 3090647 SGTC_2572 astragaloside iv 100 µM 1.02426541127825 0.174418983546854 no 638 0.152854965240628 759 45006101 An anti-inflammatory agent. SGTC_3339 9145883 14.936 µM 1.02222864501034 0.1749007452487 no 639 0.153336348091359 744 2030670 SGTC_2148 5546263 113.568 µM 1.0204271942389 0.175327550199937 no 640 0.15376295103929 770 792097 SGTC_1604 st002052 72.4 µM 1.01942577960515 0.175565093602957 no 641 0.154000436252696 773 6254834 YHR062C RPP1 SGTC_137 0438-0332 85.389 µM 1.01769902810064 0.175975171406062 no 642 0.154410504648757 852 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1396 3511-0007 98.6 µM 1.01745676128818 0.176032754649513 no 643 0.154468095788422 698 X1396 SGTC_1105 epirubicin 18.1 µM 1.01672104140478 0.17620769751403 no 644 0.15464307654475 764 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_747 3448-8087 38.7 µM 1.01441765179412 0.176756119328943 no 645 0.155191752480161 800 5168703 SGTC_520 3584-0023 682 µM 1.0130939519636 0.177071771191813 no 646 0.155507643428105 726 1340790 SGTC_584 0986-0246 15.4 µM 1.00920099594655 0.178002154706679 no 647 0.15643912455001 866 53315 YDR232W HEM1 SGTC_1437 4092-1038 11.6 µM 1.00847131424537 0.178176884866186 no 648 0.156614126074728 836 3977136 SGTC_2514 salinomycin 42.74 µM 1.00782092935432 0.17833271764177 no 649 0.156770218217761 874 23682228 A polyether potassium ionophore. SGTC_2644 guaiazulene 100 µM 1.00411964255719 0.17922118335182 no 650 0.157660474328937 805 3515 A coloring agent. SGTC_150 3970-0969 77.2 µM 1.00260895096193 0.179584612008014 no 651 0.158024787678036 836 6615640 SGTC_1628 st004252 77.7 µM 1.00164022393884 0.179817903228853 no 652 0.158258693247559 800 692968 SGTC_2820 7989630 71.43 µM 1.00028286421539 0.180145106016264 no 653 0.158586818752618 682 2984098 SGTC_2569 tetrandrine 100 µM 1.00011877973361 0.180184685242864 no 654 0.158626514420194 715 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.995417149473994 0.181321095290653 no 655 0.159766710582058 788 6710655 SGTC_2044 5102272 200 µM 0.994939449224565 0.181436808715647 no 656 0.159882857391029 737 592666 SGTC_605 1315-0399 119 µM 0.994054876305847 0.181651201013479 no 657 0.160098075960488 853 24020461 SGTC_2121 5257820 149.641 µM 0.993564188360844 0.18177019646888 no 658 0.16021754307597 876 791256 SGTC_638 3970-0837 4.09 µM 0.99355748217235 0.181771823106898 no 659 0.160219176225955 799 4118451 YLR208W SEC13 SGTC_2366 9070441 60.58 µM 0.991737378704909 0.182213639908263 no 660 0.160662826079378 821 6837235 SGTC_3281 9140613 49.47 µM 0.991668512378045 0.182230369872639 no 661 0.160679627970292 737 16013766 SGTC_841 0251-0215 91.2 µM 0.991645198244678 0.182236033883156 no 662 0.160685316373437 850 3888614 SGTC_479 n-linoleoylglycine 10 µM 0.991331465223567 0.182312263893787 no 663 0.16076187672076 765 6433346 An anti-infammatory. SGTC_695 3505-6186 243 µM 0.990068006284161 0.182619457424051 no 664 0.161070439990665 819 1819379 SGTC_1534 6-azauridine 81.6 µM 0.989981962318285 0.182640389639302 no 665 0.161091467785554 873 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_609 0986-0026 86.3 µM 0.987971292733473 0.183129958723979 no 666 0.161583353868304 818 2848610 SGTC_2663 amphotericin b 100 µM 0.986942635635311 0.183380738136203 no 667 0.161835380630232 779 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.985371352164254 0.183764219151854 no 668 0.162220848066308 837 229346 A bile salt which induces apoptosis. SGTC_1046 2001-0062 216 µM 0.984591907988327 0.183954632340824 no 669 0.162412283029081 799 739778 SGTC_3329 9141233 27.5565 µM 0.982980993570454 0.18434855753479 no 670 0.162808396546811 807 4909101 YNL103W MET4 SGTC_529 4076-0302 30.3 µM 0.981813229197644 0.184634444845116 no 671 0.163095934778163 801 5816522 SGTC_632 0781-2353 4.65 µM 0.981285651012179 0.184763694742835 no 672 0.163225948355746 828 6811515 YHR007C ERG11 SGTC_2532 xanthone 78.9 µM 0.978309828854086 0.185493785951451 no 673 0.163960555076283 752 7020 An insecticide. SGTC_166 k072-0058 166.424 µM 0.978185254429447 0.185524388163214 no 674 0.163991354028361 831 5846229 SGTC_2241 6772625 37.8075 µM 0.973503743809807 0.186676690737054 no 675 0.165151500214603 777 2285411 SGTC_1165 k072-0275 30.3 µM 0.970822246981759 0.187338703201086 no 676 0.165818401102529 815 6153523 YGL055W OLE1 SGTC_1905 st060207 84.5 µM 0.968815290058957 0.187835132528236 no 677 0.166318678190076 829 1948547 SGTC_557 1315-0110 16.2 µM 0.967612692012831 0.188132989140267 no 678 0.166618918092761 840 6833801 SGTC_1096 rimcazole 32.2 µM 0.965689537019617 0.188609916978886 no 679 0.167099778305628 797 18528119 A dopamine reuptake inhibitor. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.964666113095032 0.1888640219504 no 680 0.167356036733832 877 6708561 SGTC_2246 7293507 91.5585 µM 0.96380494780272 0.189078003226143 no 681 0.16757186280315 872 887656 SGTC_2567 aureobasidin a 60 nM 0.960653508211015 0.189862341263891 no 682 0.168363207410428 809 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_426 0988-0037 14.6 µM 0.960461167805447 0.189910276102729 no 683 0.168411582887573 890 5383008 SGTC_2051 5263410 176 µM 0.957606508659176 0.190622585139644 no 684 0.169130607950195 874 227584 SGTC_2782 7736369 71.43 µM 0.957492420659416 0.19065108699613 no 685 0.169159385082554 868 2950836 YOL077C BRX1 SGTC_876 0720-0963 56.8 µM 0.951232446882448 0.192218982304794 no 686 0.170743195325007 888 765861 SGTC_2330 7979373 200 µM 0.951141013539406 0.192241941313929 no 687 0.17076639860353 834 1863007 SGTC_1574 spiramycin 23.7 µM 0.949529747052864 0.192646807215348 no 688 0.171175625014586 848 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1120 ficusin 1.78878 µM 0.949253783532258 0.19271620130781 no 689 0.171245776556724 866 6199 A DNA cross-linker. SGTC_2698 st077697 67.5 µM 0.948233970109117 0.192972777210271 no 690 0.17150517855145 801 3154499 SGTC_2114 5491910 81.25 µM 0.94817917762908 0.192986568409078 no 691 0.171519122792183 862 2849228 SGTC_2645 abamectin 100 µM 0.947885207060141 0.193060570711117 no 692 0.171593948282327 841 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1856 st057054 55.7 µM 0.947362705697053 0.193192144676513 no 693 0.171726994088587 902 1266018 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.94203845875711 0.194535991210716 no 694 0.173086475112163 815 6708514 SGTC_2111 5486399 200 µM 0.940767127230278 0.194857716308022 no 695 0.173412105163896 888 689674 SGTC_1733 st037357 54.9 µM 0.938716129603166 0.195377426519761 no 696 0.173938254921952 839 1272339 YGL099W LSG1 SGTC_271 rotenone 740 µM 0.938689478065072 0.195384185393201 no 697 0.173945098610539 869 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1933 st074711 15.9 µM 0.938613366901755 0.195403488090084 no 698 0.173964643682229 908 17250958 SGTC_3090 9117696 49.47 µM 0.937961993420932 0.195568731530829 no 699 0.174131971147159 851 7923821 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.937709564969973 0.195632791555294 no 700 0.174196843487121 895 23847180 SGTC_1960 st011366 51.8 µM 0.935086425533198 0.19629923247987 no 701 0.174871880799172 885 3972846 SGTC_2250 alverine citrate 130 µM 0.9322919521782 0.197010714953194 no 702 0.175592832840539 911 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3202 9113761 49.47 µM 0.930919877007612 0.197360620578208 no 703 0.175947505849053 951 4798415 SGTC_3043 9092303 49.47 µM 0.928550452793571 0.197965753703112 no 704 0.176561054740479 828 25236084 SGTC_2190 6049624 200 µM 0.928329452652332 0.198022252557226 no 705 0.176618350374987 820 2265554 SGTC_2452 5863136 48.41 µM 0.927795619718948 0.198158767516842 no 706 0.176756798313644 876 2184096 SGTC_512 prima-1 270 µM 0.926717674990878 0.198434599151459 no 707 0.177036569056554 924 322968 A re-activator of the apoptotic function of mutant p53. SGTC_355 1311-2252 105 µM 0.926020702135901 0.198613068433227 no 708 0.177217610865212 847 5338538 SGTC_1863 st057641 20.1 µM 0.925897832002072 0.198644541019486 no 709 0.177249539050136 952 3921635 SGTC_645 0845-0943 5.41 µM 0.924923454723132 0.198894229493564 no 710 0.17750286262165 846 1885106 SGTC_1488 4013-0813 75.9 µM 0.923423895063727 0.199278867649031 no 711 0.177893172017007 856 2910057 SGTC_574 1315-0397 40 µM 0.922615359081996 0.199486443472254 no 712 0.178103844355663 1003 6794277 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.92116796399463 0.199858358769562 no 713 0.17848137059113 949 66535 A nucleotide analog. SGTC_1299 1079-1439 3.74 µM 0.920016902237817 0.200154427240694 no 714 0.178781963325507 858 323161 SGTC_2308 7584454 197.62 µM 0.916310484572756 0.201109556868552 no 715 0.17975203522621 919 893577 SGTC_1195 1502-0147 41.1 µM 0.914210994984612 0.201651797925597 no 716 0.180302993934632 927 817940 SGTC_2033 5192550 145 µM 0.912995988638957 0.201966000679584 no 717 0.180622325631616 860 182073 SGTC_2260 7964312 200 µM 0.912881835773597 0.201995535861134 no 718 0.18065234585335 834 231951 SGTC_3328 9140624 29.0385 µM 0.911869152088031 0.202257664330218 no 719 0.180918801057249 917 4904392 SGTC_488 nitrendipine 139 µM 0.908093841172396 0.203236677812062 no 720 0.181914322061653 931 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1469 k284-2957 126 µM 0.906049916202063 0.203767886432684 no 721 0.182454716320844 906 23884841 SGTC_1028 k015-0029 4.8 µM 0.904364841975796 0.204206452898039 no 722 0.182900987208407 892 4588309 SGTC_343 4130-2827 29.8 µM 0.904219799369431 0.204244228722562 no 723 0.182939431749138 897 1118244 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.904092189593731 0.20427746766996 no 724 0.182973259767866 851 77254 SGTC_2289 7946404 165.07 µM 0.902134732270882 0.204787736686205 no 725 0.183492650316031 943 1246120 YPR165W RHO1 SGTC_561 1550-0330 72.9 µM 0.900033675502058 0.205336281786099 no 726 0.184051164928167 864 6812934 SGTC_2161 5662504 8.5105 µM 0.897770078137807 0.205928238658078 no 727 0.184654069973919 862 2859334 SGTC_1082 camptothecin 424.86 nM 0.897373360008647 0.206032089188748 no 728 0.184759861454935 827 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_623 k072-0108 16.9 µM 0.89669284679627 0.206210302237346 no 729 0.184941419335912 901 5382803 SGTC_1169 aniline yellow 25.8 µM 0.895901545591143 0.206417643349781 no 730 0.185152674310709 888 6051 A DNA damaging agent. SGTC_1016 4226-1401 38 µM 0.895693328522263 0.206472222057582 no 731 0.185208287260177 913 2901613 SGTC_813 k007-0158 173 µM 0.890664751703483 0.207792927820356 no 732 0.186554525023965 995 6523916 SGTC_1154 4088-0362 150 µM 0.889997783353104 0.207968474453101 no 733 0.186733538157359 978 6618304 SGTC_3027 9089541 49.47 µM 0.887974276585868 0.208501598646001 no 734 0.187277294180243 901 9943819 SGTC_922 1866-0035 480 µM 0.886552735090814 0.20887660722037 no 735 0.187659875146052 1004 3156169 SGTC_1947 st076332 61.6 µM 0.885960898569879 0.20903285324754 no 736 0.187819298989978 915 24208416 SGTC_131 0141-0277 33.849 µM 0.884970369708768 0.209294508800752 no 737 0.188086306228067 918 1547771 SGTC_777 1315-0167 517 µM 0.883843137179569 0.209592510034072 no 738 0.188390448204789 870 4221767 SGTC_1293 1000-1278 195 µM 0.88354711208118 0.209670810170496 no 739 0.188470369886131 943 678847 SGTC_3139 9095020 49.47 µM 0.881317676615079 0.210261059514067 no 740 0.189072950607553 756 25236292 SGTC_2013 4024628 200 µM 0.880508449071541 0.21047554593185 no 741 0.189291965053581 877 5230760 SGTC_23 0213-0011 39.996 µM 0.880469693942944 0.210485821231602 no 742 0.189302457903469 930 627608 SGTC_504 lovastatin 124 µM 0.880060202732414 0.210594409237251 no 743 0.189413348457452 875 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1426 4048-4480 71.7 µM 0.878893505141567 0.210903971806152 no 744 0.189729510270946 952 14224343 SGTC_229 benomyl 22.8748 µM 0.876274221206944 0.211599923604539 no 745 0.19044048787824 928 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2109 5483026 200 µM 0.87617346341253 0.211626722085714 no 746 0.19046787018093 935 759335 SGTC_1249 0481-0015 10.2 µM 0.875943222436613 0.211687966575785 no 747 0.190530450374914 905 4227577 SGTC_1859 st055998 20 µM 0.874418164598086 0.212093896390361 no 748 0.190945284373245 974 676301 SGTC_1433 4060-0023 7.6 µM 0.873780975249143 0.212263633960013 no 749 0.191118771482125 954 3840627 SGTC_1153 4055-0057 267 µM 0.871385528488511 0.212902454504993 no 750 0.191771842366566 956 882706 SGTC_2896 9052656 71.43 µM 0.868244173101806 0.213741893022833 no 751 0.19263033840599 969 6469436 SGTC_1390 3413-2614 145 µM 0.86802948730986 0.213799332027122 no 752 0.192689095166254 986 3421432 SGTC_760 0568-0725 82.9 µM 0.865034282330688 0.214601633701772 no 753 0.193509986357452 997 3916171 SGTC_753 1322-0200 289 µM 0.863317800899417 0.215062201609717 no 754 0.193981379816734 970 5403907 SGTC_671 0560-0003 407 µM 0.860914735713117 0.215707957517075 no 755 0.194642502574208 924 3238678 SGTC_2522 biochanin a 4.94 µM 0.8607027360915 0.215764980335369 no 756 0.194700892893834 953 5280373 A possible chelator. SGTC_3140 9094243 49.47 µM 0.858401857131631 0.216384423432326 no 757 0.195335301235575 1050 19291112 SGTC_1952 st077036 64.1 µM 0.857958489701783 0.216503905070221 no 758 0.195457692585696 1015 2937007 SGTC_620 0109-0052 432 µM 0.854758001413034 0.217367525820943 no 759 0.196342566617563 989 493037 SGTC_3106 9121286 49.47 µM 0.854719189595723 0.217378011006485 no 760 0.196353312226537 930 15943471 SGTC_1500 4488-1866 171 µM 0.853106604672395 0.217813916086195 no 761 0.196800094562747 1047 2900003 SGTC_1424 4048-1941 275 µM 0.85189518102488 0.218141712845293 no 762 0.197136135866117 1056 X1424 SGTC_2226 7298446 200 µM 0.851358319500913 0.218287072027183 no 763 0.19728516884171 957 3283010 SGTC_2603 homopterocarpin 100 µM 0.850543850579621 0.21850770195638 no 764 0.197511395827044 963 101795 A weak amylase inhibitor. SGTC_644 1498-1197 63.3 µM 0.849692427141726 0.218738479644544 no 765 0.19774805490481 1007 6741615 SGTC_2737 bleomycin 30.5 nM 0.843342200370877 0.220464122637075 no 766 0.199518543823289 1029 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1100 amiodarone 5.07 µM 0.842971927196714 0.220564982705648 no 767 0.199622072183804 1027 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.842805508665374 0.220610322670051 no 768 0.199668613324123 942 803109 SGTC_2739 tacrine 100.86 µM 0.842798777977616 0.220612156527349 no 769 0.199670495787209 967 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1503 4585-0012 61.3 µM 0.841877628560829 0.220863217201404 no 770 0.199928226911732 978 2922052 SGTC_3352 9151559 45.5865 µM 0.841183348450566 0.22105255236231 no 771 0.200122613748097 946 17159339 SGTC_406 estrone 100 µM 0.838293719339848 0.221841572000095 no 772 0.20093288121486 1002 5870 A steroid. SGTC_2850 9015429 58.44 µM 0.838041101737734 0.221910626172973 no 773 0.201003809979127 965 6457570 SGTC_2451 5856223 45.7 µM 0.837479022449429 0.222064317141689 no 774 0.201161681796985 960 2179896 SGTC_733 4069-0007 56.1 µM 0.834215340089432 0.222957915101239 no 775 0.202079824173649 1012 5717425 YNL287W SEC21 SGTC_217 ketoconazole 989 nM 0.833941476866958 0.223032992028937 no 776 0.202156981525237 973 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_5 0352-0601 109.883 µM 0.833642959608151 0.223114844017209 no 777 0.202241104901279 943 762456 SGTC_1079 idarubicin 2.36 µM 0.832266747032436 0.223492415956511 no 778 0.20262919791754 977 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1974 st069448 26.9 µM 0.831672976013319 0.223655432668924 no 779 0.202796779164874 1005 6323587 YNR016C ACC1 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.828980273483113 0.224395547968698 no 780 0.203557784864452 987 2724278 An inhibitor of dopamine biosynthesis. SGTC_361 000s-0510 1.45 µM 0.828533725602478 0.22451842020633 no 781 0.203684151692644 973 660 SGTC_1018 4259-0013 28.1 µM 0.826922434339262 0.224962100813731 no 782 0.204140513398151 990 6801262 SGTC_1291 0993-0025 5.79 µM 0.825270481460121 0.225417493352227 no 783 0.204609023274367 1017 4353356 SGTC_1353 1498-1206 8.11 µM 0.82497790010077 0.225498203391283 no 784 0.20469206882667 1034 6756808 SGTC_1768 st044301 37.178 µM 0.824761292380703 0.225557966255816 no 785 0.204753563128463 1059 3931349 SGTC_2982 9019404 25.97 µM 0.824349374202812 0.225671640719651 no 786 0.204870535813694 940 22333232 SGTC_2314 7727897 200 µM 0.823721608626415 0.225844943553074 no 787 0.205048879235367 1013 900724 SGTC_1321 1326-2144 215 µM 0.822431633527879 0.226201294044047 no 788 0.205415640846502 1018 3513030 SGTC_2405 ticlatone 3.52 µM 0.821589929748477 0.226433982541254 no 789 0.205655161282523 1020 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_31 0508-1974 57.237 µM 0.820754176895825 0.226665159586589 no 790 0.205893152227187 990 6810525 SGTC_1447 4239-0816 81.9 µM 0.818701325516367 0.227233562503557 no 791 0.20647842009648 954 1341554 SGTC_2560 caryophyllene 100 µM 0.818285363187937 0.227348833860496 no 792 0.206597130920624 1110 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1901 st060216 58.6 µM 0.816262774242511 0.227909802431488 no 793 0.20717493022518 1051 688792 SGTC_3296 9122258 64.045 µM 0.814227627840257 0.228475038995685 no 794 0.207757280479019 1006 4730474 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.81388857684916 0.228569282659054 no 795 0.207854392646913 940 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1925 st057770 10.1 µM 0.812009313082798 0.229092044366821 no 796 0.208393143803827 952 5989122 SGTC_1777 st045864 34.765 µM 0.811842932248798 0.229138359429609 no 797 0.208440881854768 1026 4691462 SGTC_1771 st048882 4.1505 µM 0.810591985460824 0.229486750834176 no 798 0.208800010452643 1047 4580403 SGTC_941 3237-0776 460 µM 0.810124165388546 0.229617115964371 no 799 0.208934408395185 1004 760008 SGTC_2860 9025725 38.96 µM 0.809858808325407 0.229691080154277 no 800 0.209010664287481 963 40546248 SGTC_2099 5377090 177.372 µM 0.809686760350538 0.229739043004362 no 801 0.209060114623186 991 2243829 SGTC_643 k048-0106 28.4 µM 0.806434571820823 0.230646729535573 no 802 0.209996159795445 1024 6763920 SGTC_1746 st038117 42 µM 0.805971528472831 0.23077612779022 no 803 0.210129632962062 996 2898218 SGTC_679 0422-0091 41.4 µM 0.804788705250745 0.231106853768353 no 804 0.210470810268004 1090 627384 YHR062C RPP1 SGTC_1979 st071809 45.3 µM 0.80159980512131 0.231999809923243 no 805 0.2113922451966 1051 4976333 SGTC_2271 7849410 118.62 µM 0.800141684447559 0.232408752176629 no 806 0.211814356121994 1053 972430 SGTC_1131 3454-3128 32.3 µM 0.800048297280768 0.232434957050445 no 807 0.211841407539436 1068 710982 SGTC_663 1486-0733 13.9 µM 0.799296979965805 0.232645839968605 no 808 0.212059114813213 1033 722445 YPR165W RHO1 SGTC_1780 st038448 24.544 µM 0.798750251174138 0.2327993649473 no 809 0.212217621211804 1028 728868 YDL195W SEC31 SGTC_866 0495-0101 262 µM 0.798725669034214 0.232806269093294 no 810 0.212224749637872 970 635694 SGTC_1386 3228-0095 33.8 µM 0.798576559498099 0.232848150473046 no 811 0.212267992009656 1014 870181 SGTC_2992 9074591 71.4286 µM 0.797070728497445 0.233271337676792 no 812 0.212704977649459 1010 17741321 SGTC_1524 corynanthine 62.1 µM 0.796425415304988 0.233452822121412 no 813 0.212892405408127 1010 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2507 purpurin 79.67 µM 0.796319716091925 0.233482555868326 no 814 0.212923114362418 1065 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_317 4495-0002 170 µM 0.794718658875664 0.233933198515357 no 815 0.213388588012243 987 15991618 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.794033050380857 0.234126321030684 no 816 0.213588095489955 985 15053 SGTC_2312 7706453 155.7 µM 0.793135424655568 0.234379298060151 no 817 0.213849462784743 1014 976098 SGTC_1673 st016611 27.3 µM 0.793068336407883 0.234398211552403 no 818 0.213869004766318 1054 5226799 SGTC_2801 7907800 81.82 µM 0.792553014625507 0.234543519020835 no 819 0.214019146329677 1057 6620925 SGTC_429 1112-0049 25.5 µM 0.79232797178035 0.234606990933947 no 820 0.214084732923025 962 2836170 SGTC_1204 4049-0315 18.3 µM 0.789966299484407 0.235273658326163 no 821 0.214773724972558 1007 588402 SGTC_3325 9138760 55.175 µM 0.78979064747882 0.235323284209432 no 822 0.21482502094615 1030 43844959 SGTC_1622 st003707 19.4 µM 0.788301716411277 0.235744174770049 no 823 0.215260121964605 1069 10140899 SGTC_2813 7971799 71.43 µM 0.787705747006677 0.235912759469525 no 824 0.215434421598444 1020 2234054 SGTC_907 3448-6986 75.5 µM 0.786801156292748 0.23616877227277 no 825 0.21569913825856 1088 590582 SGTC_1336 1486-0901 104 µM 0.785763407720748 0.236462659137327 no 826 0.216003053954526 1049 5006114 SGTC_2786 7743617 45.45 µM 0.785056605321148 0.23666293834844 no 827 0.216210190487434 975 583674 SGTC_999 SEC7.066 22.7 µM 0.78487711826344 0.236713812573783 no 828 0.216262809530129 1095 740511 YDR170C SEC7 SGTC_958 1222-0007 33 µM 0.781372914517419 0.237708256322687 no 829 0.217291598333621 1098 7312461 SGTC_664 1222-0054 14.9 µM 0.78100343943976 0.237813241553537 no 830 0.217400235900778 1086 6813991 SGTC_1693 xanthone 101.9 µM 0.780843472377106 0.237858703599987 no 831 0.217447281093171 1084 7020 An insecticide. SGTC_262 fenpropimorph 62.5 µM 0.779507103106539 0.238238680943951 no 832 0.217840527503589 987 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2153 5569715 200 µM 0.778240622310607 0.238599093196921 no 833 0.21821358647212 1057 2054701 SGTC_79 0052-0007 94.094 µM 0.777039760059264 0.238941107309602 no 834 0.218567656400034 1066 2801472 SGTC_2399 5884133 200 µM 0.776692247815849 0.239040131259139 no 835 0.218670180815306 1088 722445 SGTC_3171 9103192 49.47 µM 0.768547745990148 0.241367327114935 no 836 0.221080918032474 1151 13018434 SGTC_1877 wortmannin 25 µM 0.768282411733715 0.241443349748753 no 837 0.221159710781491 1109 312145 A covalent inhibitor of PI 3-kinase. SGTC_1237 0330-0133 46.1 µM 0.768086439167445 0.241499507465743 no 838 0.221217916435143 1036 X1237 YHR072W ERG7 SGTC_1292 0kpi-0043 232 µM 0.767981353698411 0.241529623581961 no 839 0.221249131394405 1049 3333905 SGTC_2536 dehydroabietamide 32.04 µM 0.767058134627587 0.241794293697321 no 840 0.221523475924662 1100 3983547 SGTC_1170 0310-0127 64.8 µM 0.766988586645198 0.241814238211736 no 841 0.221544150732723 1081 774975 SGTC_3017 9080681 49.47 µM 0.766415338132465 0.241978664660965 no 842 0.221714604625895 1062 16451914 SGTC_2091 4-phenylthiadiazole 200 µM 0.766248610054159 0.242026499116214 no 843 0.221764194830716 1085 270010 SGTC_70 0141-0289 43.283 µM 0.764842872775623 0.242430010392618 no 844 0.222182557417556 1160 352408 SGTC_3205 9113483 49.47 µM 0.764438929723604 0.242546028008122 no 845 0.222302858487597 1072 17018033 SGTC_3206 9114350 49.47 µM 0.764254794302885 0.242598924033975 no 846 0.222357709457673 1004 17087243 SGTC_307 1501-1223 22.3 µM 0.764215732087562 0.242610146121613 no 847 0.222369346453724 1097 2830329 SGTC_1274 0865-0114 173 µM 0.763296079448302 0.242874432056354 no 848 0.222643419850795 1092 870624 SGTC_2904 7225135 42.03 µM 0.763048930099978 0.242945483352621 no 849 0.222717107715874 1141 4446116 SGTC_2052 5265182 7.135 µM 0.762431932332601 0.243122908938252 no 850 0.222901126967923 1087 1239884 SGTC_1116 jasmonic acid  1.58368 µM 0.760685785471474 0.243625415274809 no 851 0.223422383503553 1104 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_10 0279-0212 42.575 µM 0.757832289948372 0.244447800233972 no 852 0.224275694609711 1149 39851 YBR002C RER2 SGTC_1761 st044296 37 µM 0.756583167517623 0.244808270758381 no 853 0.22464981445767 1142 1826700 SGTC_966 1300-0360 30.2 µM 0.75626737784277 0.244899446322606 no 854 0.22474445143443 1081 70588 SGTC_2120 5538279 151.968 µM 0.756150258344055 0.244933265994434 no 855 0.224779555970271 1097 2058197 SGTC_989 1501-0895 10.3 µM 0.755382729764693 0.245154961340567 no 856 0.225009686271416 1110 2830112 SGTC_1980 st071811 45.7 µM 0.753246258629863 0.245772634141358 no 857 0.225650973179467 1119 4974850 SGTC_2809 7964133 12.99 µM 0.75202553078123 0.246125932126553 no 858 0.226017852732916 1093 1253665 SGTC_303 1348-1668 34.2 µM 0.750663809460694 0.246520357029495 no 859 0.226427504267141 1102 5380509 SGTC_2526 patulin 37.61 µM 0.75058368804141 0.246543574879401 no 860 0.2264516205364 1128 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2685 mycophenolic acid 18.85 µM 0.749457362960387 0.246870089038939 no 861 0.226790793949837 1086 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1984 st072354 53.1 µM 0.74895596891273 0.247015514258498 no 862 0.226941872282591 1090 5762938 SGTC_1212 0520-0165 585 µM 0.748888214445526 0.247035169399173 no 863 0.226962292178418 1118 5403258 SGTC_1057 3448-5381 134 µM 0.748845092701693 0.247047679178937 no 864 0.226975288783834 1130 5497911 SGTC_2295 7971645 200 µM 0.74856710121063 0.247128333688294 no 865 0.227059083634786 1077 2978226 YKL099C UTP11 SGTC_2269 7935389 174.42 µM 0.747580337308981 0.247414740160801 no 866 0.227356664233091 1055 97605 SGTC_1902 st060212 70.5 µM 0.74565641688491 0.247973664383401 no 867 0.227937496587607 1166 688944 SGTC_1301 naphtanilide LB 4.81 µM 0.741549344106513 0.249169073964517 no 868 0.229180212313094 1173 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2923 7992654 58.14 µM 0.738695167159693 0.250001615747532 no 869 0.230046060537202 1127 2985126 SGTC_440 fluspirilene 35.1 µM 0.738426400451331 0.250080088931548 no 870 0.230127688280689 1133 3396 An atypical antipsychotic. SGTC_256 clotrimazole 625 nM 0.738262168059922 0.250128047130346 no 871 0.230177575646016 1108 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3248 9135562 49.47 µM 0.738226768137438 0.250138385051268 no 872 0.230188329547848 1160 17650701 SGTC_717 1532-0246 73.2 µM 0.737053096895772 0.250481263249065 no 873 0.230545030240475 1119 9561992 SGTC_1263 0774-1208 64.8 µM 0.73615517154249 0.250743752667905 no 874 0.230818135029872 1166 906585 SGTC_3300 9124615 50.48 µM 0.734888148748511 0.251114387521685 no 875 0.23120380829611 1136 24824903 SGTC_506 n9-isopropylolomoucine 153 µM 0.734603743779802 0.25119762267182 no 876 0.231290428650846 1137 6610355 SGTC_3324 9138759 60.749 µM 0.734061676363773 0.251356306791937 no 877 0.231455574591889 1137 45595710 SGTC_1366 1683-0113 21.9 µM 0.73097101400898 0.252262074757689 no 878 0.232398429006717 1153 708623 SGTC_1457 k015-0032 57.3 µM 0.730509039685082 0.252397611408417 no 879 0.23253954472951 1106 4302660 SGTC_3172 9105863 49.47 µM 0.730381728238147 0.252434969508845 no 880 0.232578441944713 1112 2348785 SGTC_599 1935-0052 86.5 µM 0.729379357022315 0.252729205742003 no 881 0.232884820771376 1149 9557311 SGTC_1402 3909-7673 35.9 µM 0.728918895604849 0.25286443018269 no 882 0.233025637789902 1149 5328014 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.728807903565771 0.252897031087887 no 883 0.23305958813496 1156 279621 SGTC_3330 9141424 71.43 µM 0.728674562708759 0.252936199278084 no 884 0.233100378188196 1155 27261020 SGTC_3099 9120367 49.47 µM 0.727967315766677 0.253144002788529 no 885 0.233316797037731 1182 24824940 SGTC_610 4215-0184 155 µM 0.727856197045986 0.253176659885067 no 886 0.233350809700495 1152 5605015 SGTC_1591 genipin 88.4 µM 0.726668693729412 0.25352579799294 no 887 0.233714467907837 1099 442424 A DNA cross-linking agent. SGTC_65 0798-0905 34.986 µM 0.726372200217221 0.25361300956262 no 888 0.233805314367225 1211 3602145 SGTC_1632 st005650 90 µM 0.726229036548922 0.253655125832199 no 889 0.233849187129649 1125 2759605 SGTC_2905 7799065 20.05 µM 0.724837356060371 0.254064725441204 no 890 0.234275907743756 1108 1296806 SGTC_3176 9106582 49.47 µM 0.7214031309891 0.255076969704446 no 891 0.23533076039635 1060 17018027 SGTC_2248 tofa 1.1 µM 0.718658657601645 0.255887422345627 no 892 0.23617563106649 1100 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2974 9094440 9.66 µM 0.718173472795243 0.256030838782045 no 893 0.236325166070083 1155 25236134 SGTC_71 0417-1750 47.813 µM 0.718127798891033 0.256044341752553 no 894 0.236339245549965 1151 6811472 SGTC_186 3455-3465 67.277 µM 0.71695140296495 0.256392257793355 no 895 0.236702041531892 1109 755278 SGTC_661 1304-0007 33.6 µM 0.715992646155474 0.256675989729888 no 896 0.236997944864594 1152 3117130 SGTC_2237 6667747 47.222 µM 0.715942717173224 0.256690770057307 no 897 0.237013360129512 1104 729940 YDL015C TSC13 SGTC_2655 perillic acid 100 µM 0.712212783236814 0.257796183071471 no 898 0.238166511121083 1157 5702197 An apoptosis inducer. SGTC_1634 st006576 41 µM 0.711323691017201 0.258060040953016 no 899 0.238441836998003 1165 3915356 SGTC_1148 3909-7663 27.7 µM 0.711168832366231 0.258106013017871 no 900 0.238489810010616 1214 4084526 SGTC_1571 st070080 73.4 µM 0.7100221137459 0.25844656538655 no 901 0.238845211549461 1178 4315245 SGTC_2608 thymoquinone 42.66 µM 0.709840769604241 0.258500442257431 no 902 0.238901441902532 1112 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2544 sphondin 68.51 µM 0.709156060719958 0.258703919914494 no 903 0.239113818524664 1195 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1957 st077035 62.4 µM 0.707757110849497 0.259119908994448 no 904 0.239548052368998 1233 705593 SGTC_2939 9044578 71.43 µM 0.70668511034784 0.259438910907581 no 905 0.239881092302367 1168 2653634 SGTC_1302 1159-0335 255 µM 0.699253846012799 0.261655842780627 no 906 0.242196702575561 1178 649284 SGTC_741 4582-0002 126 µM 0.694672536564912 0.263027389797405 no 907 0.243630271426284 1179 2912688 SGTC_2240 6690706 185.951 µM 0.693954051389139 0.263242821880597 no 908 0.24385551245187 1136 805876 SGTC_775 4577-0580 57.3 µM 0.693237862256212 0.263457655170747 no 909 0.244080145475427 1253 2006902 SGTC_21 0849-0113 22.993 µM 0.69317379985954 0.263476876151861 no 910 0.244100244109597 1179 1560156 SGTC_393 acivicin 6.25 µM 0.692360057470319 0.263721089875707 no 911 0.244355621467061 1115 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2473 5854593 8.94 µM 0.691616885425286 0.263944225427874 no 912 0.244588977425161 1147 2872951 SGTC_2167 5876490 200 µM 0.690578026446633 0.264256301439609 no 913 0.244915380110577 1225 686534 SGTC_1123 mangostin 811.285 nM 0.690266510604012 0.264349918236519 no 914 0.245013302009024 1162 5281650 An antioxidant. SGTC_2925 9010536 32.5 µM 0.689980168931378 0.264435984577173 no 915 0.245103329232738 1196 2994177 SGTC_3128 9127691 49.47 µM 0.689235777448478 0.264659794656578 no 916 0.245337452780868 1151 41316314 SGTC_1848 st056003 16.4 µM 0.686696076865374 0.265424109991307 no 917 0.246137134853263 1266 146492 SGTC_725 1497-0963 19 µM 0.684712732522859 0.266021769485946 no 918 0.246762606422086 1238 3549977 SGTC_2110 5483698 200 µM 0.682330915431885 0.26674040420417 no 919 0.247514864352633 1215 2848765 YHR062C RPP1 SGTC_222 nsc-310342 10.666 µM 0.681393777526297 0.267023423381711 no 920 0.247811179556787 1178 432556 SGTC_3349 9149703 23.001 µM 0.681072537235511 0.26712047404837 no 921 0.247912796630528 1212 4910494 SGTC_1717 st033143 58.0435 µM 0.68044131811877 0.267311225012716 no 922 0.248112533234018 1234 674616 SGTC_1913 st060213 96.1 µM 0.680302220400189 0.267353268821788 no 923 0.248156559450766 1240 688959 SGTC_1892 st058411 7.36 µM 0.679939159817644 0.26746302357505 no 924 0.24827149242224 1191 3934738 SGTC_1259 0671-0132 43 µM 0.67641025377043 0.268531009278213 no 925 0.249390104433788 1173 X1259 SGTC_2155 5570423 76 µM 0.674096081516138 0.269232530723565 no 926 0.250125115290569 1196 797402 SGTC_3326 9140064 16.379 µM 0.673000236433346 0.269565047174246 no 927 0.250473570252548 1215 1868434 SGTC_2626 ethyl orsellinate 100 µM 0.672808987447292 0.269623099666736 no 928 0.250534409635706 1230 75653 A natural product. SGTC_2425 5628681 7.85 µM 0.669898831488603 0.270507232250273 no 929 0.251461142349976 1242 5714958 SGTC_1794 st048918 76.9 µM 0.669235134572 0.270709072235998 no 930 0.251672748566595 1177 672303 SGTC_1993 st073995 70.8 µM 0.666989326408444 0.271392612760019 no 931 0.25238947562278 1241 3098394 SGTC_2929 9013348 24.6 µM 0.666404494184525 0.27157075497645 no 932 0.252576295341936 1249 2995952 SGTC_2105 5350118 200 µM 0.665550676465197 0.271830935762221 no 933 0.252849170966969 1254 2133313 SGTC_1971 st069429 63.5 µM 0.664878440374807 0.272035871067536 no 934 0.253064123205211 1244 1246522 YGL099W LSG1 SGTC_1348 1493-0373 93.8 µM 0.664311625635747 0.27220872770562 no 935 0.253245440896254 1246 3010129 SGTC_2983 9022671 12.99 µM 0.663141437577039 0.272565762530737 no 936 0.253619986935003 1258 6405161 SGTC_2129 girgensonine 121.053 µM 0.66229188195751 0.272825115112481 no 937 0.253892089256243 1286 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2506 ethyl hematommate 54.16 µM 0.66075492321637 0.27329462915284 no 938 0.254384747494407 1216 3940691 An allergen. SGTC_1269 0831-0796 3.05 µM 0.660274950697398 0.273441334333063 no 939 0.254538700950033 1244 927758 SGTC_2766 oltipraz 83.91 µM 0.659249235910848 0.273754978062751 no 940 0.254867867361701 1254 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1287 0971-0001 34.6 µM 0.657263022990926 0.274362828956436 no 941 0.255505904094722 1260 4665869 SGTC_315 k915-0449 187 µM 0.656833046480442 0.274494504540822 no 942 0.255644136447193 1292 20970215 YNL149C PGA2 SGTC_1557 sumaresinolic acid 42.3 µM 0.656610489605752 0.274562672384868 no 943 0.255715701181201 1211 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_830 4076-0286 57.8 µM 0.656149851394653 0.274703789648979 no 944 0.255863855872737 1301 6866659 SGTC_2696 st077691 74.316 µM 0.653945440995943 0.275379609066059 no 945 0.256573478275206 1253 757133 SGTC_1103 duloxetine 36.1 µM 0.653932057101943 0.275383714744644 no 946 0.256577789817008 1327 60835 A selective serotonin reuptake inhibitor. SGTC_1013 4112-3890 241 µM 0.653751503719389 0.275439104719678 no 947 0.256635957702768 1221 705171 SGTC_2564 betulinic acid 100 µM 0.652262397080058 0.275896140174062 no 948 0.257115956704114 1307 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_125 0133-0007 11.75 µM 0.651734166527759 0.276058353753944 no 949 0.257286338780078 1331 26541 SGTC_2659 sanguinarine 24.21 µM 0.651103305660963 0.276252145272375 no 950 0.257489901388213 1226 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1442 4112-3290 3 µM 0.651054354233419 0.276267185247629 no 951 0.257505700254401 1251 704353 SGTC_2345 9052315 157.45 µM 0.650427578251524 0.276459793173826 no 952 0.257708034041676 1267 6469265 SGTC_2837 9008476 45.46 µM 0.645984783448089 0.277826946193496 no 953 0.259144605010395 1297 2992805 SGTC_3010 9080089 71.4286 µM 0.645088968127068 0.278103009098913 no 954 0.259434766258119 1288 17027233 SGTC_2552 juarezic acid 87.02 µM 0.64500234351362 0.278129711250884 no 955 0.259462833510827 1320 1549512 SGTC_1045 1348-1485 165 µM 0.644420072321183 0.278309229563996 no 956 0.25965153597167 1287 6810614 SGTC_1147 3809-1045 12.3 µM 0.64404878513541 0.278423729504105 no 957 0.259771899710217 1232 325925 SGTC_1930 st074634 34.3 µM 0.643674158902798 0.278539282421144 no 958 0.259893375074812 1253 684253 YOR116C RPO31 SGTC_247 mechlorethamine 29.705 µM 0.643024821809865 0.278739624822627 no 959 0.260103996885442 1199 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2891 9063876 19.48 µM 0.642293743850943 0.27896527095243 no 960 0.260341237784788 1249 6472478 SGTC_3254 9136651 49.47 µM 0.642043895092648 0.279042406768886 no 961 0.260422341343191 1257 16454030 SGTC_72 0744-0168 198.391 µM 0.639888247394239 0.279708350419218 no 962 0.261122627546931 1239 677577 SGTC_3291 9121177 71.43 µM 0.638566814734441 0.280116961179486 no 963 0.261552387704887 1240 17015612 SGTC_44 0929-0055 61.211 µM 0.636632210796482 0.280715696794722 no 964 0.26218221944605 1237 1379590 SGTC_1590 st077108 57.8 µM 0.634805910420858 0.281281481190917 no 965 0.262777504021247 1277 5489485 SGTC_2143 5623677 140.463 µM 0.633522833385937 0.281679305000283 no 966 0.263196137425226 1259 5375313 SGTC_1617 st002906 78 µM 0.632938314797933 0.281860627517857 no 967 0.263386962956208 1309 5150859 SGTC_590 k048-0076 22.4 µM 0.631811595531715 0.282210303799101 no 968 0.263754997858849 1337 6832814 SGTC_2192 5915882 198.485 µM 0.63005791491418 0.282754971987997 no 969 0.264328346583028 1249 2876149 SGTC_2743 auranofin 4.32 µM 0.629289682789403 0.282993732907701 no 970 0.264579712279979 1246 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2003 4023581 200 µM 0.628063565464326 0.283375001581043 no 971 0.264981149874077 1327 16641307 SGTC_1987 st072290 61.9 µM 0.627300857875912 0.283612294347645 no 972 0.265231020600849 1318 54697379 SGTC_3038 9091290 49.47 µM 0.626689827274054 0.28380246618688 no 973 0.265431286688457 1325 25236843 SGTC_2194 5927483 104.545 µM 0.626578237368453 0.283837203048326 no 974 0.265467868711846 1315 760979 SGTC_1743 st037606 46.3785 µM 0.625680053906203 0.284116872995187 no 975 0.26576240933743 1334 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_857 0438-0306 1.35 µM 0.623852219969396 0.284686417522548 no 976 0.266362320704458 1328 4686136 SGTC_2931 9014674 55.67 µM 0.62217612611382 0.285209159096606 no 977 0.266913031249485 1290 2996810 SGTC_1704 st028805 70.8 µM 0.62122305074747 0.285506608901227 no 978 0.267226437488814 1297 2876101 SGTC_690 glyoxal 20.3 µM 0.619969973269905 0.285897912360747 no 979 0.26763877787893 1209 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2973 9094665 17.96 µM 0.617727233605971 0.286598897409893 no 980 0.268377578435939 1361 25237061 YIL048W NEO1 SGTC_35 0133-0054 64.071 µM 0.617485112516408 0.286674622893848 no 981 0.268457398966287 1257 99677 SGTC_33 0986-0033 35.816 µM 0.615642710099432 0.287251160879706 no 982 0.269065178076954 1284 2848082 SGTC_2100 5377183 190 µM 0.614656989373344 0.287559844952159 no 983 0.269390634914085 1337 2844202 SGTC_3122 9126309 49.47 µM 0.614481075298757 0.287614949935233 no 984 0.269448737465756 1342 17591206 SGTC_624 k048-0052 28 µM 0.614359152947618 0.28765314497012 no 985 0.269489010809483 1295 6835531 SGTC_3223 9129970 49.47 µM 0.61304238284615 0.28806580674798 no 986 0.269924157950767 1383 17248386 SGTC_2398 5228213 48.84 µM 0.611740028090009 0.288474225522718 no 987 0.270354886977527 1349 80771 YMR134W ERG29 SGTC_1554 st069299 38.7 µM 0.609187481541978 0.289275495385791 no 988 0.271200088497956 1330 24207999 SGTC_3136 9095672 49.47 µM 0.608777902609936 0.289404163629858 no 989 0.271335831192212 1200 17217380 SGTC_1112 tnp00069 1.16933 µM 0.608689156120409 0.289432046671353 no 990 0.271365248025892 1403 145826 SGTC_3060 1327-0027 12.5 µM 0.608566185937453 0.289470684456607 no 991 0.271406011627119 1252 16000455 YPR107C YTH1 SGTC_976 1348-1067 47.6 µM 0.606910221166155 0.289991231863826 no 992 0.27195524728243 1359 5310671 YGL099W LSG1 SGTC_1464 k208-0027 110 µM 0.606518913695159 0.29011430223448 no 993 0.272085113367073 1417 X1464 SGTC_2775 cyproheptadine 69.59 µM 0.606175737789026 0.29022225485713 no 994 0.272199031047445 1330 2913 A selective serotonin reuptake inhibitor. SGTC_451 chloral hydrate 100 µM 0.603443051634388 0.291082544958686 no 995 0.273106994757908 1382 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_351 caspofungin 25 nM 0.602447758154197 0.291396173741097 no 996 0.273438063988217 1388 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2595 hexamethylquercetagetin 100 µM 0.602146914845451 0.291491004057536 no 997 0.273538174028505 1325 386331 SGTC_2576 guaiol 23.12 µM 0.601855826569236 0.291582773140767 no 998 0.273635055202309 1328 227829 SGTC_1978 st071761 42 µM 0.600878824729216 0.291890883173283 no 999 0.273960348960879 1294 5147680 SGTC_980 1473-0395 201 µM 0.600713726558944 0.291942963967858 no 1000 0.274015337437757 1287 768876 SGTC_2096 5468907 200 µM 0.599547588373416 0.292310949501252 no 1001 0.274403892892345 1351 759785 SGTC_961 1252-1571 372 µM 0.597679815799993 0.29290079119298 no 1002 0.275026797914046 1398 6813498 SGTC_2056 5235370 200 µM 0.59484485015562 0.293797126005216 no 1003 0.275973592314852 1331 5511916 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.594501429053713 0.293905792027406 no 1004 0.276088393383044 1397 65057 A dermal irritant. YDR527W RBA50 SGTC_100 0086-0128 49.5915 µM 0.593823908069384 0.294120229124144 no 1005 0.276314948292527 1285 93297 SGTC_839 0122-0028 230 µM 0.593168649338102 0.294327688914496 no 1006 0.27653414569523 1342 759448 SGTC_405 ebelactone b 50 µM 0.593062860615112 0.294361188746019 no 1007 0.276569542170369 1339 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2305 7443522 69.23 µM 0.592180187246066 0.294640771160231 no 1008 0.276864967623724 1340 5415886 SGTC_592 k241-0073 46.5 µM 0.591039157809399 0.295002367985508 no 1009 0.277247092164237 1395 4230158 SGTC_2755 lomerizine 42.69 µM 0.586905738600153 0.296313973699882 no 1010 0.278633507733906 1356 3949 A calcium channel blocker. SGTC_2496 diffractaic acid 79.83 µM 0.586509069539109 0.296439984180562 no 1011 0.278766734276525 1457 94870 An apoptosis inducer which activates caspases. SGTC_2384 9036245 200 µM 0.584883328820171 0.296956692202247 no 1012 0.279313084493704 1425 6462766 SGTC_2692 st077426 47.7 µM 0.583807858971245 0.297298734303175 no 1013 0.279674795100129 1353 25238571 SGTC_2182 6325192 200 µM 0.583502636480471 0.297395839954863 no 1014 0.279777491363131 1313 736248 SGTC_729 4092-0585 94.1 µM 0.583228132283332 0.297483185042053 no 1015 0.279869867661061 1329 2169061 SGTC_1141 3253-0389 52.6 µM 0.582147611379584 0.297827112083919 no 1016 0.280233628777546 1341 5402031 SGTC_1945 st075991 56.6 µM 0.582010514699911 0.29787076256733 no 1017 0.280279799219853 1281 1084980 SGTC_621 3584-0052 32.1 µM 0.581114650425297 0.298156070353646 no 1018 0.280581592671434 1374 2273927 SGTC_258 haloperidol 50.781 µM 0.580955848331424 0.298206657377363 no 1019 0.280635105382726 1312 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_329 k048-0121 21.3 µM 0.580313175449911 0.298411423228348 no 1020 0.280851722009467 1372 6832902 SGTC_759 3486-0358 89.3 µM 0.580292480694841 0.298418017971344 no 1021 0.280858698640014 1397 875103 SGTC_1271 0832-2808 169 µM 0.580127354261852 0.298470640751817 no 1022 0.280914369181724 1391 3663794 SGTC_1683 st010134 710 nM 0.579712658580881 0.298602815309241 no 1023 0.281054202734631 1347 3818134 SGTC_373 0844-0104 25.9 µM 0.578764083040912 0.298905251631937 no 1024 0.281374184600325 1385 5375804 SGTC_2730 imipramine 71.33 µM 0.577512986519276 0.299304354007342 no 1025 0.281796484195683 1394 3696 A tricyclic antidepressant. SGTC_3179 9107801 49.47 µM 0.576391957475743 0.299662169788422 no 1026 0.282175139644556 1352 4818259 SGTC_292 k038-0015 474 µM 0.574459580471313 0.300279410235701 no 1027 0.282828422427508 1380 46368540 SGTC_2892 9047358 58.44 µM 0.572613912496095 0.300869490045886 no 1028 0.28345306881456 1354 6466771 SGTC_1907 st060210 83.7 µM 0.569333356467038 0.301919607689211 no 1029 0.284564967018048 1455 688793 SGTC_2220 6782180 200 µM 0.569208388240677 0.301959643003779 no 1030 0.284607364387504 1352 833803 SGTC_1872 amphotericin b 148 nM 0.569102805589656 0.301993469737324 no 1031 0.284643187256489 1379 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3062 9077494 49.47 µM 0.568163094014285 0.302294610945955 no 1032 0.284962114410562 1404 16459633 SGTC_2534 helenine 20.12 µM 0.566864048983344 0.302711126326394 no 1033 0.285403275580825 1415 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2027 5150920 200 µM 0.56619831115075 0.302924682753286 no 1034 0.2856294889383 1392 786715 SGTC_2808 7946468 45.46 µM 0.566139716234893 0.302943482150881 no 1035 0.285649403191635 1424 2970879 SGTC_2008 4012253 172 µM 0.56558885545294 0.303120244012913 no 1036 0.285836652771017 1390 603940 SGTC_1257 0669-0121 16 µM 0.56478089357762 0.303379588661793 no 1037 0.28611140215481 1440 4307855 SGTC_55 0767-0285 6.563 µM 0.563547312188258 0.303775742450802 no 1038 0.286531126331062 1356 3116166 SGTC_2154 5570129 200 µM 0.561174929553432 0.304538260211276 no 1039 0.2873391459601 1379 673366 SGTC_782 0083-0095 30.5 µM 0.56061695618984 0.304717724465773 no 1040 0.287529344895776 1396 3591729 An indicator and reagent. SGTC_482 fipronil 114 µM 0.560606696473947 0.304721024798749 no 1041 0.287532842729376 1415 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1389 3405-0187 19 µM 0.559723315781504 0.305005249200133 no 1042 0.287834088146072 1347 799890 SGTC_3120 9124077 49.47 µM 0.558222552550808 0.30548838381638 no 1043 0.288346211289104 1417 18774327 YGL155W CDC43 SGTC_2915 7971052 15.16 µM 0.557073324592527 0.305858579315911 no 1044 0.288738666128784 1281 5741558 SGTC_2234 tolnaftate 200 µM 0.556420826355948 0.306068853911712 no 1045 0.288961602463948 1394 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1855 st056195 39.6 µM 0.556245774434027 0.306125277159081 no 1046 0.28902142549503 1447 4028379 SGTC_2229 7354935 190 µM 0.554787332235623 0.306595545208385 no 1047 0.289520066417602 1391 318112 SGTC_2032 5185112 25.99 µM 0.554127476637528 0.30680841737827 no 1048 0.28974580349956 1355 5718189 SGTC_2986 9022445 71.43 µM 0.553862852459965 0.306893804553607 no 1049 0.28983635481986 1439 6459286 SGTC_2709 st078560 56 µM 0.553859418640643 0.30689491262453 no 1050 0.289837529920194 1500 17250903 SGTC_2364 9055074 200 µM 0.55346617822558 0.307021820388757 no 1051 0.289972116994628 1373 6470630 SGTC_3127 9126946 49.47 µM 0.55275294004222 0.307252057821586 no 1052 0.290216298490059 1353 27243249 SGTC_1379 2144-0755 36.5 µM 0.544414229474142 0.309949460733552 no 1053 0.293078228033809 1450 5392327 SGTC_2607 solasodine 47.35 µM 0.544353196719446 0.309969241587352 no 1054 0.293099223265202 1419 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1663 st014140 55.4 µM 0.544078845118058 0.310058166354971 no 1055 0.293193608667677 1493 4207120 SGTC_354 2783-3500 4.88 µM 0.5403071902531 0.311281786100966 no 1056 0.294492600273284 1373 6740761 SGTC_2830 7992007 71.43 µM 0.540008750432942 0.31137869681324 no 1057 0.294595498916028 1440 1952075 SGTC_2232 chlorophetanol 41.5365 µM 0.539204368792904 0.311639964299696 no 1058 0.294872923093445 1496 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3209 9113616 49.47 µM 0.538797791471374 0.311772058899742 no 1059 0.295013193846241 1510 16649353 SGTC_2040 5100729 123 µM 0.53766857505299 0.312139061735684 no 1060 0.295402939043555 1453 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2112 5488546 200 µM 0.535284832175098 0.312914406138608 no 1061 0.296226456576827 1398 600757 SGTC_2278 7948257 134.34 µM 0.534195555648207 0.313268983901414 no 1062 0.296603121845693 1433 1247028 SGTC_1193 1488-0126 41.5 µM 0.5333344424422 0.313549412927821 no 1063 0.296901044792523 1445 1384710 SGTC_1125 tnp00248 1.32998 µM 0.532630040911796 0.313778887594848 no 1064 0.297144851314073 1546 24207736 SGTC_985 1493-0307 8.71 µM 0.532276273408343 0.313894162516612 no 1065 0.297267331370032 1443 3278274 SGTC_713 1488-1073 324 µM 0.531442135202154 0.314166037833837 no 1066 0.297556214855656 1427 3312542 SGTC_1816 st051957 91.6 µM 0.531030421840381 0.31430026705632 no 1067 0.297698848990381 1434 674121 SGTC_1662 st014054 52 µM 0.530065531888058 0.314614942382608 no 1068 0.298033247999096 1422 2838777 SGTC_1906 st060206 94.7 µM 0.528393588703859 0.315160524711915 no 1069 0.298613093233978 1440 5133468 SGTC_1510 1123-0200 71.5 µM 0.527700652217255 0.315386759509118 no 1070 0.298853560246177 1554 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_597 k018-0003 82.8 µM 0.526070505398571 0.315919254250678 no 1071 0.299419610319346 1541 6786234 SGTC_1611 st001856 99.4 µM 0.525929009029546 0.315965492714587 no 1072 0.299468766257195 1389 647478 SGTC_472 calcifediol 10 µM 0.525814194174703 0.316003014256551 no 1073 0.299508655706832 1455 5283731 A vitamin D metabolite. SGTC_3321 9137793 26.8275 µM 0.524371596047851 0.316474617342521 no 1074 0.300010054185404 1444 4904192 SGTC_3081 9117243 49.47 µM 0.524086813528105 0.316567751565794 no 1075 0.300109079857947 1539 45595589 SGTC_2350 9023895 38.85 µM 0.52040319972576 0.317773473526979 no 1076 0.301391290194322 1518 2997209 SGTC_9 0092-0002 10.449 µM 0.52005491025163 0.317887576094818 no 1077 0.301512652008602 1450 759368 SGTC_156 3474-0145 5.642 µM 0.51906462940519 0.318212094904045 no 1078 0.301857836435847 1460 2265471 SGTC_2924 9010168 62.78 µM 0.518483389934249 0.318402634320598 no 1079 0.302060523059856 1464 2993929 SGTC_3064 1327-0027 10 µM 0.518443979942404 0.318415555274 no 1080 0.302074268107045 1384 16000455 YPR107C YTH1 SGTC_2647 atorvastatin 60.16 µM 0.517229876007297 0.318813719342825 no 1081 0.302497849404606 1499 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1002 4049-0206 172 µM 0.517229737432053 0.318813764800377 no 1082 0.302497897766471 1442 4662749 SGTC_1664 st014217 9.02 µM 0.514801298807427 0.319610796111509 no 1083 0.30334593883759 1517 3982782 SGTC_2264 7948757 110.76 µM 0.512857536298079 0.320249354293867 no 1084 0.304025489525937 1439 2971411 SGTC_1630 st005209 31.3 µM 0.512342238584416 0.320418727532901 no 1085 0.304205754339237 1483 3367314 SGTC_911 3456-4043 236 µM 0.510324876347533 0.321082174119426 no 1086 0.304911938780628 1563 914281 SGTC_3217 9129673 49.47 µM 0.508850011010425 0.321567572465401 no 1087 0.3054286807646 1462 17248312 SGTC_2199 6590217 200 µM 0.508671035824601 0.321626496399715 no 1088 0.305491413913609 1492 703109 SGTC_2967 9089538 49.85 µM 0.508228522820105 0.321772204054564 no 1089 0.305646545038202 1604 728216 SGTC_2484 5809818 12.04 µM 0.50818018928395 0.321788120651742 no 1090 0.305663491368063 1477 2870548 SGTC_2880 9042983 58.44 µM 0.50764512021885 0.321964344765525 no 1091 0.305851120940122 1468 6464714 SGTC_2386 9075165 157.42 µM 0.505391858294478 0.322706891868046 no 1092 0.306641818077764 1438 16452277 SGTC_419 nsc-638432 893 µM 0.505139367041322 0.322790142776367 no 1093 0.306730476532698 1477 368090 SGTC_335 4077-0256 27.6 µM 0.504734270612503 0.322923728911884 no 1094 0.306872743593452 1498 3121989 SGTC_2857 9024691 58.44 µM 0.502907121755995 0.323526540184552 no 1095 0.307514786892252 1497 16478292 SGTC_1196 1588-0294 184 µM 0.502701395257342 0.323594442338075 no 1096 0.307587114290851 1443 6144269 SGTC_2740 felodipine 17.08 µM 0.49996688096505 0.324497554183823 no 1097 0.30854919888639 1556 3333 L-type calcium channel blocker SGTC_2772 vinpocetine 57.06 µM 0.4992434061981 0.324736664949726 no 1098 0.308803959534571 1529 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1176 0848-0131 83.3 µM 0.499108212293843 0.324781354989156 no 1099 0.308851576223031 1548 6769040 SGTC_2136 5328288 199.296 µM 0.498800218101078 0.324883175746854 no 1100 0.308960066953681 1445 262395 SGTC_3075 9116269 49.47 µM 0.493696174537745 0.326572437463007 no 1101 0.3107603836532 1521 17015205 YNL244C SUI1 SGTC_2017 5132927 60.65 µM 0.493648815003797 0.326588128561308 no 1102 0.310777109802993 1451 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_981 1488-1094 54.9 µM 0.490225921654111 0.327723007938419 no 1103 0.311987019966324 1453 3449522 SGTC_3146 9095609 49.47 µM 0.489978868891 0.327804981427534 no 1104 0.312074425903863 1563 17173999 SGTC_330 1488-0319 80.1 µM 0.48957870772066 0.327937774747433 no 1105 0.312216023219369 1509 6846614 SGTC_2439 5492030 7.2 µM 0.488106544621952 0.328426498609407 no 1106 0.312737187825954 1525 5722370 SGTC_2773 thioridazine 9.09 µM 0.487341847265779 0.328680476288201 no 1107 0.313008048384752 1509 5452 An antipsychotic. SGTC_809 3998-0021 90 µM 0.483571203302637 0.329933969615593 no 1108 0.314345107877612 1500 715485 SGTC_248 streptozotocin 5.23457 mM 0.483479919799985 0.329964339189122 no 1109 0.314377507055856 1596 5300 DNA alkylating agent. SGTC_1121 fusaric acid 630.51 nM 0.48322117318218 0.330050429009506 no 1110 0.314469351549688 1484 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3022 9087993 49.47 µM 0.481982803435932 0.330462582248287 no 1111 0.314909081219385 1558 17173644 SGTC_387 norethindrone acetate 66.7 µM 0.481770630317813 0.330533218193686 no 1112 0.314984447609151 1493 541197 SGTC_1332 1480-0653 17.5 µM 0.481192733189111 0.3307256403289 no 1113 0.315189762535405 1515 5749438 SGTC_2714 st079313 56.9 µM 0.480031967095331 0.331112275218543 no 1114 0.315602331261188 1507 2939799 SGTC_3115 9123671 49.47 µM 0.47740855615047 0.331986759731712 no 1115 0.316535611331827 1581 3286988 SGTC_1505 k297-0037 20.6 µM 0.476268108071733 0.332367201200263 no 1116 0.316941691477447 1486 4089396 SGTC_553 k007-0256 45.7 µM 0.476131551251033 0.332412766707906 no 1117 0.316990330158666 1544 6287000 SGTC_306 1672-3436 11.6 µM 0.474930835610972 0.332813521282003 no 1118 0.317418136015474 1550 6797378 SGTC_979 1426-2828 121 µM 0.473534670409333 0.333279749966765 no 1119 0.317915885878337 1598 747872 SGTC_906 1165-0455 526 µM 0.47351873081158 0.333285074248582 no 1120 0.317921570440663 1477 3252859 SGTC_1527 coumarin 137 µM 0.47331645831842 0.333352641967773 no 1121 0.317993710905604 1568 323 A hepatotoxic, DNA x-linker. SGTC_2941 9056145 11.23 µM 0.471524890829905 0.333951338480614 no 1122 0.318632974527783 1451 2119517 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.470264005102132 0.334372948225729 no 1123 0.319083205326002 1488 6312947 SGTC_123 0083-0120 66.675 µM 0.469785853993817 0.334532885098965 no 1124 0.319254011008533 1449 16001701 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.468321542083517 0.335022869839634 no 1125 0.319777332738086 1492 91467 include heat shock SGTC_2404 5161160 200 µM 0.468281354529574 0.335036321272435 no 1126 0.319791700194644 1572 2831543 SGTC_2418 pentamidine 31.67 µM 0.466549793052493 0.335616104043383 no 1127 0.320411007483983 1461 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1081 sertraline 6 µM 0.464975637687786 0.336143522032456 no 1128 0.320974451548106 1613 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1066 ketoconazole 628 nM 0.464850476891352 0.336185470800627 no 1129 0.321019268599254 1608 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_627 1391-0720 175 µM 0.464204289124965 0.336402078893751 no 1130 0.321250694266454 1523 997839 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.46418750103855 0.336407707139121 no 1131 0.321256707676874 1711 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_975 1335-0046 28.5 µM 0.464179437053638 0.336410410622022 no 1132 0.321259596173479 1459 16486740 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.464067404962779 0.336447970699415 no 1133 0.321299726870259 1605 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2341 7987486 176.74 µM 0.46405663772427 0.33645158062886 no 1134 0.321303583882062 1663 1258686 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.464023627615933 0.336462648013839 no 1135 0.321315408796187 1528 5106787 A p450 inhibitor. SGTC_2174 5790901 200 µM 0.463932712127414 0.336493130218891 no 1136 0.321347977570066 1532 786020 SGTC_1174 0739-0097 51.1 µM 0.463600033428686 0.336604680111858 no 1137 0.321467165202492 1539 728447 SGTC_2031 5180455 200 µM 0.46280903739701 0.336869965287799 no 1138 0.321750626380746 1504 29949 SGTC_2612 dictamnine 15.46 µM 0.461809623915019 0.337205265819306 no 1139 0.322108924388625 1537 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_323 4013-0906 34.3 µM 0.461591573430958 0.337278438368359 no 1140 0.322187119283154 1613 2910086 SGTC_3141 9094609 49.47 µM 0.461132802203799 0.337432411162002 no 1141 0.322351664531079 1477 25236309 YDL196W YDL196W SGTC_2274 7947094 46.08 µM 0.460785595794297 0.337548958673567 no 1142 0.322476218513345 1493 2971028 SGTC_2236 dapsone 200 µM 0.459624529158768 0.337938809510051 no 1143 0.322892874724361 1554 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2588 indole-3-carbinol 100 µM 0.459035134682084 0.33813677680567 no 1144 0.323104467849022 1663 3712 Induces cell cycle arrest. SGTC_415 dibenzyl ketone 100 µM 0.459008372682407 0.338145766756094 no 1145 0.323114076789265 1638 7593 SGTC_2965 9082772 38.63 µM 0.458209091312086 0.338414305649842 no 1146 0.323401114469772 1662 16459634 SGTC_773 4358-1457 44.6 µM 0.45804025891807 0.338471039703895 no 1147 0.323461758962573 1685 1186886 SGTC_1246 0422-0085 105 µM 0.457514315630978 0.338647799987776 no 1148 0.323650707525279 1618 264295 SGTC_2622 2-methoxyxanthone 59.94 µM 0.457012554894491 0.338816466075894 no 1149 0.323831010732701 1689 71034 A hepatoprotective. SGTC_2351 9026858 72.31 µM 0.456971048622556 0.338830419792345 no 1150 0.323845927490419 1462 1409300 SGTC_2638 epoxomicin 18 µM 0.456333405567849 0.339044812541708 no 1151 0.324075122789963 1646 9915668 A protesome inhibitor. SGTC_517 1365-0151 113 µM 0.456263435986809 0.339068341372786 no 1152 0.324100276815208 1567 768657 SGTC_2674 ligustilide 100 µM 0.454983943745263 0.339498709763622 no 1153 0.324560395069633 1545 5319022 A signalling regulator. SGTC_1014 4130-3005 69.3 µM 0.454657688712713 0.339608482019006 no 1154 0.32467776254875 1514 743608 SGTC_2800 7887935 81.82 µM 0.451173054483829 0.340781774418084 no 1155 0.325932414219136 1589 2961002 SGTC_853 0419-0306 21 µM 0.450254523509585 0.341091305290036 no 1156 0.326263462955965 1489 762713 SGTC_1792 st045773 43.6 µM 0.449618490250662 0.341305701454981 no 1157 0.326492776643119 1545 2919270 SGTC_3159 9100096 49.47 µM 0.449156742187236 0.34146138109997 no 1158 0.326659295119078 1475 25236875 SGTC_374 0880-0231 82.3 µM 0.447352829152675 0.342069833767316 no 1159 0.327310164302224 1551 6833587 SGTC_1186 1319-0216 26 µM 0.447097678020001 0.342155928385482 no 1160 0.327402267742628 1697 4565136 SGTC_1051 3253-3903 78 µM 0.446682339569171 0.342296091913942 no 1161 0.327552217434914 1517 5509239 SGTC_80 0159-0065 512.242 µM 0.446006370312826 0.342524256505286 no 1162 0.327796322177527 1558 1548079 SGTC_3116 9124943 49.47 µM 0.443856755483197 0.343250212568272 no 1163 0.328573075806771 1473 41905195 YPL160W CDC60 SGTC_1489 4065-0444 182 µM 0.443276853518429 0.343446153107013 no 1164 0.328782747881958 1657 2877968 SGTC_3272 9137413 49.47 µM 0.439210301189611 0.344821362307814 no 1165 0.330254580806397 1472 17614870 SGTC_181 1447-1644 8.07 µM 0.437524973603724 0.345391901886143 no 1166 0.330865334351917 1642 534600 SGTC_3055 9094636 49.47 µM 0.437274953194956 0.345476572100344 no 1167 0.33095597879643 1616 25236176 SGTC_204 PMA1.184 62.41 µM 0.437000490680976 0.345569528615102 no 1168 0.33105549609269 1565 2252213 YGL008C PMA1 SGTC_968 1309-0633 340 µM 0.432495961412133 0.347096475105745 no 1169 0.332690493413818 1638 3761976 SGTC_448 monastrol 171 µM 0.430247735527766 0.34785951089873 no 1170 0.333507720614728 1613 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1221 2958-7315 257 µM 0.429715601976696 0.34804020452241 no 1171 0.333701266348179 1598 4562705 SGTC_390 dec-rvkr-cmk 16.7 µM 0.428937962876155 0.348304325151632 no 1172 0.33398418608408 1612 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1678 st019265 80.2 µM 0.428796929303084 0.348352234276321 no 1173 0.334035506866825 1731 5367020 SGTC_701 4424-0219 185 µM 0.427332054266636 0.348849995492434 no 1174 0.33456874441575 1691 2911779 SGTC_32 0928-0142 34.1 µM 0.426588176473276 0.349102863171529 no 1175 0.334839655521225 1608 2244242 SGTC_438 sphingosine 6.67 µM 0.426183004433281 0.349240622210182 no 1176 0.334987250352389 1433 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2352 9027995 87.8 µM 0.426173419212882 0.349243881438619 no 1177 0.334990742335855 1635 2997347 SGTC_2356 9061756 188.97 µM 0.425965447404091 0.349314600091055 no 1178 0.335066511880042 1660 20104043 SGTC_94 0334-0113 514.748 µM 0.424222670735037 0.349907418586901 no 1179 0.335701714345103 1529 6795178 SGTC_1107 amlodipine 47 µM 0.42420844228264 0.349912260009601 no 1180 0.335706902228016 1538 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_76 0433-0009 400.328 µM 0.419418132900201 0.351543609856241 no 1181 0.337455287140368 1595 2841569 SGTC_1482 3346-2049 8.48 µM 0.4179811534443 0.352033511454271 no 1182 0.337980448354348 1649 3826804 SGTC_3093 9117344 49.47 µM 0.417249090382752 0.352283184261337 no 1183 0.338248110868991 1597 24824913 SGTC_1360 1598-0022 39.8 µM 0.416811699933864 0.352432388282049 no 1184 0.338408071952386 1691 761525 SGTC_783 0848-0141 92.7 µM 0.414305628185507 0.353287704661015 no 1185 0.339325146270988 1569 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_689 0833-0039 98 µM 0.413358709206584 0.353611079151309 no 1186 0.339671910966121 1706 5374726 SGTC_2198 6589944 200 µM 0.413136786106185 0.353686881572593 no 1187 0.339753199546333 1653 5290268 SGTC_1908 st060353 56.5 µM 0.412317414591361 0.353966805081578 no 1188 0.34005339303079 1790 4227716 SGTC_19 0279-0214 38.434 µM 0.411211953861307 0.354344590906538 no 1189 0.340458561852609 1640 3566274 YBR002C RER2 SGTC_2623 humulene 100 µM 0.411036788608216 0.354404465947464 no 1190 0.340522779603952 1570 6187145 An anti-inflammatory. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.40916186320609 0.355045578662338 no 1191 0.341210439768128 1549 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1853 st056710 91.2 µM 0.408727315969239 0.355194226589501 no 1192 0.341369892619491 1754 269167 SGTC_698 k064-0052 127 µM 0.407617028861251 0.355574128557108 no 1193 0.341777430171061 1681 5088751 SGTC_1407 3909-7909 12.3 µM 0.406673866211517 0.355896959060504 no 1194 0.342123768621382 1599 4411780 SGTC_2293 7624732 200 µM 0.405840151473682 0.356182413251348 no 1195 0.342430027381796 1538 894453 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.405603200558294 0.356263557197154 no 1196 0.342517088417915 1616 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2706 st078239 82.5 µM 0.404272571973722 0.356719352357096 no 1197 0.343006146269705 1623 15434492 SGTC_737 1950-0117 57.9 µM 0.40331911839128 0.357046075432122 no 1198 0.343356739490195 1700 5393513 SGTC_2927 9011802 47.9 µM 0.403117264451416 0.357115258843956 no 1199 0.343430980253967 1536 43912568 SGTC_2988 9073640 71.4286 µM 0.402900875532671 0.357189429191739 no 1200 0.343510573612058 1652 9102229 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.402667486777596 0.357269432521928 no 1201 0.343596427721725 1750 688664 SGTC_114 0364-0001 490.298 µM 0.402188285910415 0.357433717449429 no 1202 0.343772731269616 1554 4003655 SGTC_2094 5332512 191.667 µM 0.401314917761825 0.357733203101875 no 1203 0.344094140906663 1725 755774 SGTC_2728 chlorpromazine 9.18 µM 0.401296249671701 0.357739605511795 no 1204 0.34410101221161 1650 2726 A thorazine and dopamine antagonist. SGTC_165 k038-0023 64.381 µM 0.401242972656024 0.357757877622141 no 1205 0.344120622568293 1573 46368543 SGTC_2722 naftopidil 47.16 µM 0.400647194642317 0.357962230361165 no 1206 0.344339946792713 1667 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1124 fisetin 1.16336 µM 0.399775757819954 0.358261207783755 no 1207 0.344660843791862 1597 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1077 5-fluorocytosine 377 nM 0.399564263924356 0.35833378140824 no 1208 0.344738740955513 1629 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_636 0kpi-0074 126 µM 0.399010133968766 0.3585239540421 no 1209 0.344942868610634 1624 616434 SGTC_1884 5633444 25 µM 0.398999674480262 0.358527543986133 no 1210 0.344946722059541 1656 5724239 SGTC_868 0527-0199 213 µM 0.398786967537224 0.358600552755651 no 1211 0.345025090310925 1637 2849450 SGTC_3354 9151612 71.43 µM 0.398211609322528 0.358798062537277 no 1212 0.345237104551016 1726 27261949 SGTC_2803 7707263 71.43 µM 0.397736061311754 0.358961337838166 no 1213 0.345412376317028 1596 2199229 SGTC_990 3985-0011 41.3 µM 0.397208590404818 0.35914247056074 no 1214 0.345606823980263 1622 5399565 YGL099W LSG1 SGTC_1486 3970-0793 4.53 µM 0.396488530400458 0.359389789208376 no 1215 0.345872333741787 1716 2844330 SGTC_2903 5923464 63.88 µM 0.395598358333674 0.359695617596358 no 1216 0.346200674186584 1663 2876576 SGTC_1352 1496-0991 99 µM 0.395481610800346 0.359735734163579 no 1217 0.346243745159807 1623 3000039 SGTC_2279 7948423 32.93 µM 0.395106850215134 0.359864519129949 no 1218 0.346382016789296 1801 1247112 SGTC_2940 9060638 45.86 µM 0.394991676094077 0.359904101450022 no 1219 0.346424515535976 1639 4027022 SGTC_381 3461-2219 42.7 µM 0.393206326832845 0.360517871012956 no 1220 0.347083548584509 1739 2883159 SGTC_2781 5567276 71.43 µM 0.392719644914412 0.360685245552782 no 1221 0.347263279760727 1698 2853274 SGTC_325 2810-4341 181 µM 0.391922548609812 0.36095943219533 no 1222 0.347557720874034 1755 774970 SGTC_2944 9067346 25.62 µM 0.390152093748117 0.361568691971879 no 1223 0.348212041862725 1668 6473075 SGTC_2070 5230947 200 µM 0.389830024537003 0.361679562196838 no 1224 0.348331120181049 1711 2835538 SGTC_1910 st062352 60.4 µM 0.388274956852644 0.362215047353444 no 1225 0.348906283947586 1545 2245730 SGTC_2437 5741531 144.16 µM 0.386707625901316 0.362755028321824 no 1226 0.349486334958782 1764 2262990 SGTC_3229 9132204 49.47 µM 0.386069911614696 0.362974813531529 no 1227 0.349722446344838 1696 17682924 SGTC_1319 1306-0155 43.7 µM 0.385090672970792 0.363312391347008 no 1228 0.350085119027789 1678 3122360 SGTC_1762 st045503 25.4615 µM 0.384068416554186 0.363664912186977 no 1229 0.350463869783742 1631 4645554 SGTC_675 1309-0189 238 µM 0.382608341143371 0.364168613227135 no 1230 0.35100509235387 1622 4246530 SGTC_510 ag-490 170 µM 0.377556576922084 0.36591319156565 no 1231 0.352880013779585 1764 5328779 SGTC_255 tunicamycin 200.472 nM 0.376093744930454 0.366418886527069 no 1232 0.353423602181042 1778 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_874 0599-0792 117 µM 0.375931700924998 0.366474918759412 no 1233 0.353483836159477 1807 765305 SGTC_2805 7950783 58.44 µM 0.375656182550188 0.366570195152045 no 1234 0.353586258539471 1695 1178958 YDL195W SEC31 SGTC_571 k831-0106 44.2 µM 0.375517034495888 0.366618316754853 no 1235 0.353637990062267 1769 4783639 SGTC_364 0083-0097 67.7 µM 0.375047627428564 0.366780667369155 no 1236 0.35381252298352 1680 5207356 SGTC_2602 kawain 100 µM 0.375020255862628 0.366790134921276 no 1237 0.353822701110185 1659 5369129 SGTC_920 mycophenolic acid 780.421 nM 0.373032794915601 0.367477794097439 no 1238 0.354562017972972 1625 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_368 fentichlor 4.58 µM 0.371753991035243 0.367920483698625 no 1239 0.355038011111893 1620 7329 A pesticide. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.371571481595572 0.367983678180054 no 1240 0.355105962785259 1670 689007 SGTC_487 nimodipine 119 µM 0.370628971134812 0.368310082299974 no 1241 0.355456950339237 1745 4497 L-type voltage-gated calcium channels inhibitor SGTC_143 4032-1194 15.74 µM 0.37046420314084 0.368367153453983 no 1242 0.355518321956363 1664 1806963 SGTC_2694 st077685 81.9 µM 0.370363413439648 0.368402065698377 no 1243 0.355555865238264 1613 2838096 SGTC_433 pimozide 108 µM 0.37004344165472 0.368512906970537 no 1244 0.355675061214069 1556 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_933 2914-0560 114 µM 0.368308255301941 0.369114182382678 no 1245 0.356321698837038 1833 463887 SGTC_2282 7944268 200 µM 0.363712649503432 0.370708192614133 no 1246 0.358036298232728 1751 2970414 SGTC_552 k242-0005 476 µM 0.357932599851482 0.372716185667272 no 1247 0.360196876810051 1686 4088318 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.35765921374172 0.372811246398477 no 1248 0.360299179669693 1716 688788 SGTC_681 1642-0006 26.6 µM 0.356882132620788 0.373081492239487 no 1249 0.360590023083526 1650 4446530 SGTC_3278 9139605 49.47 µM 0.356257480119048 0.373298773203345 no 1250 0.360823874499006 1773 7958859 SGTC_431 k089-0097 107 µM 0.354159315468709 0.374028899593096 no 1251 0.36160974582302 1679 5499420 SGTC_412 gemfibrozil 100 µM 0.353856511477752 0.374134307741343 no 1252 0.361723209908993 1722 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1052 3253-3998 198 µM 0.352786295682733 0.374506932569421 no 1253 0.362124329254452 1666 5450317 SGTC_1387 3342-1166 1.8 µM 0.351642917865395 0.374905160276726 no 1254 0.36255303724502 1728 3418228 SGTC_1449 4112-4002 201 µM 0.35092849720152 0.375154054006531 no 1255 0.362820995868324 1646 2059539 SGTC_2140 5586273 200 µM 0.350814870040644 0.375193644845387 no 1256 0.362863620341119 1701 854421 SGTC_2821 7996764 71.43 µM 0.350202272398387 0.375407113414288 no 1257 0.363093450746603 1728 2987135 SGTC_1625 st003711 30.1 µM 0.350102735102283 0.375441802239743 no 1258 0.363130799162102 1766 24207034 YER133W GLC7 SGTC_1487 3970-0795 2.82 µM 0.349033805203671 0.375814388571691 no 1259 0.36353196534776 1738 3765103 SGTC_2266 7929956 200 µM 0.348394610057784 0.376037241865375 no 1260 0.363771924918263 1664 2967153 SGTC_541 4513-1321 94 µM 0.346610582515354 0.376659455747944 no 1261 0.36444194727131 1659 747515 SGTC_2710 st078562 53.7235 µM 0.345492289718081 0.37704964540016 no 1262 0.364862152879979 1657 17250908 SGTC_2979 9012552 45.46 µM 0.343684371967918 0.377680721350107 no 1263 0.365541832700868 1747 17100905 SGTC_884 0851-0618 334 µM 0.340583761923611 0.378763787152986 no 1264 0.366708477730756 1821 9642473 SGTC_2458 5808907 16.39 µM 0.339642014156283 0.379092935582229 no 1265 0.367063067138293 1839 2731747 SGTC_2639 lactacystin 53 µM 0.338489323482749 0.379495929580105 no 1266 0.367497235703814 1805 3870 A proteasome inhibitor. SGTC_1992 st073643 23.3 µM 0.338030309019878 0.379656442828199 no 1267 0.367670173734545 1714 3161292 SGTC_1834 st055981 52.8 µM 0.336632416784684 0.380145400879584 no 1268 0.368197007996315 1831 471719 YDL150W RPC53 SGTC_1031 k035-0009 16 µM 0.335513695795216 0.380536847831822 no 1269 0.368618807549612 1843 5180959 SGTC_1191 1487-1166 10.6 µM 0.335484886356051 0.380546930039049 no 1270 0.368629671876526 1794 3955771 SGTC_1864 st057645 30.4 µM 0.333318505884074 0.381305312744378 no 1271 0.369446935826252 1803 688666 SGTC_1920 st075728 45.7 µM 0.333031362784713 0.381405866939806 no 1272 0.369555304535889 1883 3400306 SGTC_703 3875-0075 71.8 µM 0.331813912454723 0.381832292831917 no 1273 0.370014889147951 1773 2850814 SGTC_2270 7924575 90.91 µM 0.331331476021499 0.38200131141364 no 1274 0.37019705916304 1882 1262135 SGTC_1808 st050063 61.5 µM 0.3305265898305 0.382283348299992 no 1275 0.370501052359206 1812 4011993 SGTC_885 0865-0106 16.8 µM 0.330144585706171 0.382417226674552 no 1276 0.370645357785067 1659 2793380 SGTC_589 1227-0070 34.1 µM 0.329222995914988 0.382740267780101 no 1277 0.370993571337122 1766 2841384 SGTC_1521 st012942 49.4 µM 0.329194029114764 0.38275042271805 no 1278 0.371004517869177 1898 24207259 SGTC_407 eburnamonine 100 µM 0.328884045527425 0.382859099210451 no 1279 0.371121666967856 1700 3195 SGTC_2521 angolensin 13.4 µM 0.328131200138019 0.38312307607225 no 1280 0.371406232252048 1778 821428 A flavenoid. SGTC_26 0302-0163 425.158 µM 0.327401588160214 0.383378958195885 no 1281 0.371682082709487 1779 3100915 SGTC_1840 st055363 71 µM 0.326986382546546 0.383524597627082 no 1282 0.371839092373944 1660 676033 SGTC_863 0466-0191 129 µM 0.323548881195954 0.384730981797298 no 1283 0.373139797297322 1838 765160 YPR165W RHO1 SGTC_647 0140-0236 81 µM 0.320993853626977 0.385628387934908 no 1284 0.374107524370861 1778 990837 SGTC_897 1000-0139 31.4 µM 0.318365759439093 0.386552096503025 no 1285 0.375103754055601 1871 6151020 SGTC_18 0111-0177 500 nM 0.317191699932272 0.386964956858557 no 1286 0.375549073751058 1769 721752 SGTC_159 3970-0959 50 µM 0.315781183592764 0.387461136868331 no 1287 0.376084300599529 1829 6615653 SGTC_282 k297-0036 65.7 µM 0.315773262793117 0.387463923702997 no 1288 0.376087306857197 1793 5061378 SGTC_1351 1496-0003 46.5 µM 0.315750251348663 0.387472020025909 no 1289 0.376096040655839 1831 3891978 SGTC_708 3448-5400 146 µM 0.315448347261868 0.387578246180459 no 1290 0.376210631668546 1821 3462195 SGTC_774 k060-0086 136 µM 0.311915078687467 0.388822064420101 no 1291 0.37755253133769 1925 5911235 SGTC_536 3852-0578 10.6 µM 0.311448191454796 0.388986508543422 no 1292 0.377729961396162 1876 2869208 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.311355157506224 0.389019278760805 no 1293 0.377765319953228 1759 3256 An antibiotic and ribosome inhibitor. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.311050184345624 0.389126707843042 no 1294 0.377881235477503 1742 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1378 2093-0007 380 nM 0.309321594697147 0.389735776458147 no 1295 0.378538452859356 1746 3618014 SGTC_1819 st053448 58.6 µM 0.308987072286593 0.389853676769271 no 1296 0.378665680399256 1796 2857616 SGTC_568 1193-0097 7.48 µM 0.307852347357486 0.390253678843239 no 1297 0.37909734357868 1810 3646150 SGTC_20 0481-0013 4.944 µM 0.307182214170986 0.390489962214413 no 1298 0.379352341269452 1726 182045 SGTC_2480 5767542 37.17 µM 0.305797982450337 0.390978158753096 no 1299 0.379879232353029 1816 2867358 SGTC_155 k072-0202 43.6 µM 0.303844759292656 0.39166732171461 no 1300 0.38062308240906 1887 5857737 SGTC_3274 9138298 49.47 µM 0.303763108808675 0.391696138178274 no 1301 0.380654187167074 1781 17015756 SGTC_2268 7933382 153.85 µM 0.30324857444249 0.391877743674368 no 1302 0.380850216813914 1843 935025 YOR257W CDC31 SGTC_977 1348-1378 135 µM 0.303106210813203 0.391927995243856 no 1303 0.38090446056261 1767 X977 SGTC_1197 1601-0112 267 µM 0.302889137893358 0.392004621197926 no 1304 0.380987174738679 1726 7350313 SGTC_3301 9125354 19.7965 µM 0.302082352999683 0.39228945003422 no 1305 0.381294642337254 1731 41905162 SGTC_1341 1486-1360 280 µM 0.301635419519521 0.392447261111585 no 1306 0.381465001994857 1751 3976547 SGTC_758 0868-0029 16 µM 0.301624636689264 0.392451068720192 no 1307 0.381469112418946 1899 762687 SGTC_1180 1193-0155 285 µM 0.300394396661341 0.392885555801751 no 1308 0.38193816863216 1755 2921347 SGTC_3351 9150312 21.596 µM 0.300210188101521 0.392950624723366 no 1309 0.382008417158112 1816 4904905 SGTC_1223 0764-0573 147 µM 0.29992494703747 0.393051387769295 no 1310 0.382117202418697 1771 1609797 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.29990306019544 0.393059119718195 no 1311 0.382125550008891 1879 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_77 0828-0286 12.516 µM 0.299711989821572 0.393126620802846 no 1312 0.382198426127857 1807 745345 SGTC_1558 st069300 45.6 µM 0.299490650992026 0.393204819103901 no 1313 0.382282852150744 1899 24208000 SGTC_500 h-89 112 µM 0.298421912715566 0.393582461502645 no 1314 0.382690583314565 1908 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1443 4112-3303 14 µM 0.297029374801633 0.394074669807658 no 1315 0.383222041388614 1777 704433 SGTC_1397 3532-0190 20.1 µM 0.29700959782882 0.394081661423432 no 1316 0.383229590798889 1815 5322280 SGTC_2433 5607874 27.82 µM 0.296406378918724 0.394294929601236 no 1317 0.38345987721085 1742 2252428 SGTC_1295 1013-0063 9.78 µM 0.295942583510591 0.394458926125256 no 1318 0.383636964951777 1907 6826038 SGTC_2575 plumbagin 510 nM 0.294708244249539 0.394895475488212 no 1319 0.384108382376412 1707 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2071 5230951 39.92 µM 0.294628182036576 0.394923795693721 no 1320 0.384138965574715 1879 1799272 SGTC_3082 9117008 49.47 µM 0.294478327025884 0.394976805022221 no 1321 0.384196211066163 1784 41448529 SGTC_3241 9133421 49.47 µM 0.294469393598128 0.394979965171534 no 1322 0.384199623767668 1810 17018221 SGTC_3138 9097216 49.47 µM 0.294398463312892 0.395005056602112 no 1323 0.384226720504108 1937 25237486 SGTC_2191 5911152 200 µM 0.29226566776798 0.395759731221364 no 1324 0.38504175326008 1805 2875902 SGTC_3200 9114385 49.47 µM 0.292180981022862 0.395789705115744 no 1325 0.385074126214308 1740 17018030 YLR208W SEC13 SGTC_4 0960-0234 25.671 µM 0.290896918284707 0.396244259693864 no 1326 0.385565079149847 1782 6821112 SGTC_246 cycloheximide 667 µM 0.290532575810486 0.396373261622232 no 1327 0.385704416534264 1771 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3320 9137005 35.139 µM 0.290444916209605 0.396404300755699 no 1328 0.385737942852611 1773 4908713 SGTC_3194 9111903 49.47 µM 0.289882768022989 0.396603365772926 no 1329 0.385952962502652 1837 17087251 SGTC_1915 st067105 30.6 µM 0.289290492913809 0.396813128338241 no 1330 0.386179543499624 1767 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_614 0462-0418 107 µM 0.287765258780173 0.397353448799355 no 1331 0.386763216221429 1820 5188303 SGTC_1234 0326-0494 15.5 µM 0.286866543005914 0.397671914878975 no 1332 0.387107254542381 1885 1547813 SGTC_184 1494-0393 24.714 µM 0.284795436081798 0.398406085165683 no 1333 0.387900434488964 1745 3090647 SGTC_831 k061-1017 217 µM 0.284124888714356 0.398643859406347 no 1334 0.388157337083319 1905 1240153 SGTC_2472 5377652 49.4 µM 0.283370578874542 0.398911380555638 no 1335 0.38844638956482 1785 1610903 SGTC_2400 5203494 178.7 µM 0.282352578013714 0.399272496811811 no 1336 0.388836586718446 1765 6777674 SGTC_2561 acetosyringone 100 µM 0.281990908218214 0.399400812996933 no 1337 0.388975240860237 1809 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_362 0310-0100 9.03 µM 0.28170289355195 0.399503004983768 no 1338 0.389085667789569 1791 790235 SGTC_294 k038-0071 157 µM 0.281486552382912 0.39957977065198 no 1339 0.389168620469085 1806 24152826 SGTC_1900 st060200 72.8 µM 0.281118107610167 0.399710517112257 no 1340 0.389309906551922 1779 688945 SGTC_3213 9129884 49.47 µM 0.279929823599092 0.400132268607536 no 1341 0.389765672817613 1701 17190742 SGTC_230 MPP+ 141.667 µM 0.279898585304963 0.400143357427348 no 1342 0.389777656311626 1750 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2456 5770359 74.46 µM 0.279015109529568 0.400457002724352 no 1343 0.39011661466367 1906 3118787 SGTC_3275 9138069 49.47 µM 0.277486609188975 0.400999791575205 no 1344 0.390703243298798 1861 17617007 SGTC_2779 methotrexate 400 µM 0.277234481477555 0.401089343551657 no 1345 0.390800032243369 1914 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2683 piperine 63.03 µM 0.276741805452094 0.401264349672131 no 1346 0.390989184456329 1833 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3346 9158254 43.5805 µM 0.276223225481795 0.401448578672938 no 1347 0.391188309784339 1813 17639500 SGTC_676 falcarinol 140 µM 0.276146762713114 0.401475744436944 no 1348 0.39121767251864 1933 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3211 9128781 49.47 µM 0.275907168453607 0.401560870792943 no 1349 0.391309683959733 1731 17194361 SGTC_1401 3807-4679 7.6 µM 0.274403082074491 0.40209536992638 no 1350 0.391887437365475 1806 3291456 SGTC_24 0417-1663 219 µM 0.274158870942885 0.402182171238171 no 1351 0.391981266891425 1808 4329390 SGTC_81 0411-0046 9.971 µM 0.27304576529764 0.402577869571161 no 1352 0.392409018028451 1844 12925265 SGTC_176 1486-1328 72.834 µM 0.27292926569306 0.402619289836076 no 1353 0.392453794743606 1775 22310231 SGTC_2126 5251174 33.877 µM 0.272622073560452 0.402728514155386 no 1354 0.392571871108011 1976 790722 SGTC_2874 9043904 71.43 µM 0.271305008377574 0.40319689188372 no 1355 0.39307822737679 1807 4463428 SGTC_90 0870-0863 4.608 µM 0.271064735798136 0.403282353169372 no 1356 0.393170621638468 1784 1738164 SGTC_59 0330-0160 1.33 µM 0.270286504494108 0.403559189846372 no 1357 0.393469923484801 1869 4293482 SGTC_2666 tannic acid 100 µM 0.267912748594369 0.404403893181224 no 1358 0.394383240178569 1861 16134267 A thiamine antagonist. SGTC_457 grayanotoxin iii 135 µM 0.267741053917861 0.404465008234106 no 1359 0.394449323315774 1877 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2920 7982904 15.77 µM 0.266302752838443 0.404977065711215 no 1360 0.395003026585142 1813 6456808 SGTC_1243 0416-0003 5.65 µM 0.265810130544041 0.405152484342205 no 1361 0.395192720383698 1813 2141977 SGTC_1065 prochlorperazine maleate 2.48 µM 0.265363758830651 0.405311449991315 no 1362 0.39536462594941 1844 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1867 st057372 64 µM 0.264756172122306 0.405527853979611 no 1363 0.395598650951143 1882 688837 SGTC_2738 aclarubicin 5.55 µM 0.264320537387443 0.405683031662106 no 1364 0.395766468155383 1913 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2636 apigenin dimethyl ether 100 µM 0.260212902231031 0.407146940181365 no 1365 0.397349776221707 1869 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2181 6316240 54.2555 µM 0.260078522267763 0.407194853515345 no 1366 0.397401602374624 1787 12779990 SGTC_930 2810-3379 265 µM 0.257169712683422 0.40823233221099 no 1367 0.398523881825117 1982 1015764 SGTC_2301 7769476 200 µM 0.256637399920032 0.408422260912902 no 1368 0.398729350369773 1882 977820 SGTC_859 0439-0102 54.6 µM 0.255131912471169 0.408959533765214 no 1369 0.399310608480612 1990 610143 SGTC_1789 tunicamycin 25 nM 0.254029661680081 0.409353009550902 no 1370 0.399736321422082 1975 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2725 haloperidol 53.21 µM 0.253963428291133 0.409376656116515 no 1371 0.399761905982088 1897 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1286 0929-0070 131 µM 0.252227256634238 0.409996619405772 no 1372 0.400432705622633 1923 1420408 SGTC_1310 1188-0297 994 nM 0.250650349494569 0.410559906584202 no 1373 0.40104222536224 1908 1588352 SGTC_1410 3909-8106 77.9 µM 0.248591638958376 0.411295576374134 no 1374 0.4018383383286 1958 1039210 SGTC_2529 gangaleoidin 93.61 µM 0.248359187930243 0.411378661224747 no 1375 0.401928253889733 1882 4565183 SGTC_854 0422-0053 192 µM 0.247146429574583 0.411812201196652 no 1376 0.402397451188237 1909 3596728 SGTC_656 4090-1979 187 µM 0.246613380277407 0.412002791123977 no 1377 0.4026037241857 1994 22330961 SGTC_3036 9090181 49.47 µM 0.245113672667738 0.412539117597759 no 1378 0.403184208269761 1864 25236586 SGTC_2464 5717415 7.67 µM 0.243569209288757 0.413091620384571 no 1379 0.403782238799025 1805 5285744 SGTC_1255 0566-0045 221 µM 0.243051931755681 0.413276705257972 no 1380 0.403982583819848 1917 2788469 SGTC_2267 7931562 200 µM 0.242136258108335 0.413604385784446 no 1381 0.404337292029719 1743 934880 SGTC_600 1495-0418 41.6 µM 0.242037079628716 0.413639881146267 no 1382 0.404375715925046 1884 5377768 SGTC_1878 temozolomide 1 mM 0.241940498797933 0.413674447503921 no 1383 0.404413134321296 2033 5394 DNA alkylating agent. SGTC_905 2-aminofluorene 215 µM 0.241919987569163 0.413681788575459 no 1384 0.404421081117279 1848 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2316 5844804 197.44 µM 0.239585755239165 0.414517418488105 no 1385 0.405325704431646 2012 776813 SGTC_1752 st044819 83.042 µM 0.238565932021795 0.41488262587292 no 1386 0.405721092356572 1837 441209 YML126C ERG13 SGTC_2778 tioconazole 65.09 nM 0.238208486778413 0.415010647489824 no 1387 0.405859697530503 1871 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1349 flufenamic acid 69 µM 0.238062973936165 0.415062766559662 no 1388 0.405916125869597 1869 3371 A non-steroidal anti-inflammatory. SGTC_499 genistein 192 µM 0.238037243632564 0.415071982668051 no 1389 0.405926104012242 1945 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3008 9078912 71.4286 µM 0.237082659821821 0.415413929532914 no 1390 0.406296332189504 1844 16648731 SGTC_719 2810-4230 27.3 µM 0.236991765290718 0.415446492721843 no 1391 0.406331589326681 1909 721079 SGTC_1705 st027868 56.3335 µM 0.236485960251058 0.41562770922032 no 1392 0.406527800228436 1996 292948 SGTC_1620 st003704 16.5 µM 0.23625585420507 0.415710156040276 no 1393 0.406617070286355 1996 2834414 SGTC_148 3253-0744 288.01 µM 0.236097827678394 0.415766778973011 no 1394 0.40667837977523 1949 6893655 SGTC_1331 1472-0049 76.2 µM 0.234762401480818 0.416245349041855 no 1395 0.407196575747826 1845 24051409 SGTC_3266 9136860 49.47 µM 0.23353303401651 0.416686021183456 no 1396 0.407673760572925 1882 4871271 YPR165W RHO1 SGTC_2600 tangeritin 87.95 µM 0.23311167746404 0.416837082405957 no 1397 0.407837343685045 1847 68077 A bioactive flavone. SGTC_2390 9097792 176.6 µM 0.232823149376034 0.416940530164693 no 1398 0.407949368117636 1818 4497149 SGTC_579 4491-1009 110 µM 0.232772341099956 0.416958747365702 no 1399 0.407969095809515 2073 1271041 SGTC_3164 9100705 49.47 µM 0.231321445679129 0.417479037979827 no 1400 0.408532543601622 1977 17174235 SGTC_349 k015-0014 24 µM 0.230894060390089 0.417632325796195 no 1401 0.408698552598587 1833 2196908 SGTC_1700 st030840 7.9285 µM 0.230564407945149 0.417750568889034 no 1402 0.408826610481898 2016 5499307 SGTC_3191 9110352 49.47 µM 0.228911292079604 0.418343637247085 no 1403 0.409468931886436 1915 17122424 SGTC_1497 4476-2978 41.3 µM 0.226920489026706 0.419058099902227 no 1404 0.410242784833092 1957 1528379 SGTC_2611 pyromycin 23.93 µM 0.225746362161131 0.419479597801203 no 1405 0.410699348455233 1846 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2853 9015042 58.44 µM 0.22559345249708 0.419534497404607 no 1406 0.410758816870058 1871 6457456 SGTC_3276 9139060 49.47 µM 0.224981609368991 0.419754184892328 no 1407 0.410996790564306 1923 4870619 SGTC_2733 amorolfine 100 µM 0.22483301552314 0.419807542555866 no 1408 0.411054590434712 2057 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_929 2805-0021 398 µM 0.2245603677629 0.41990544982116 no 1409 0.411160649681379 1906 3098024 SGTC_397 arbidol 50 µM 0.223507351212187 0.420283632452224 no 1410 0.41157033119734 1997 131410 A RNA synthesis inhibitor. SGTC_1224 0823-0416 294 µM 0.22187790344885 0.420868980784629 no 1411 0.412204466155419 2005 3598164 SGTC_13 0199-0087 65 µM 0.221773446011057 0.420906511128224 no 1412 0.412245125872336 1999 4589825 SGTC_1603 st002045 67.8 µM 0.221507048996963 0.421002227733245 no 1413 0.412348824304335 2031 5887985 SGTC_580 1123-0028 41 µM 0.220823011123111 0.421248024322965 no 1414 0.412615122775082 1988 1677248 YPR107C YTH1 SGTC_3000 9075062 71.4286 µM 0.220260518887862 0.421450168697058 no 1415 0.412834133225872 1890 17057871 SGTC_938 3126-1755 342 µM 0.218706633865072 0.422008700050735 no 1416 0.41343929050586 2047 1777771 SGTC_2580 diallyl disulphide 81.36 µM 0.217324160935244 0.422505750652641 no 1417 0.413977864657142 1886 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3065 9113888 49.47 µM 0.214918549316011 0.423370951586457 no 1418 0.414915411271512 1990 16648368 SGTC_2993 9054257 71.4286 µM 0.214518889293652 0.423514729005383 no 1419 0.415071219140296 1954 6470217 YGL055W OLE1 SGTC_3342 9147791 14.508 µM 0.213999306385771 0.423701663824232 no 1420 0.415273799037951 1951 1838168 SGTC_1692 fluoroquinolonic acid 71 µM 0.213541743844107 0.423866299263002 no 1421 0.415452216503824 1986 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_52 0329-0193 875 nM 0.21250925537427 0.424237847408988 no 1422 0.415854878966822 2005 3739292 SGTC_596 1155-0152 116 µM 0.212031507177925 0.424409791224869 no 1423 0.416041226969571 1886 280313 SGTC_1372 2752-0194 270 µM 0.211583418643878 0.424571073464758 no 1424 0.416216023233863 1932 823334 SGTC_1736 st036774 51 µM 0.211342941492626 0.424657634545801 no 1425 0.41630983855735 2086 1272247 SGTC_1730 st033808 45.1 µM 0.208320875651012 0.425745752275152 no 1426 0.417489216390199 1897 1045166 SGTC_3107 9121808 49.47 µM 0.20711602987078 0.42617972432841 no 1427 0.417959621747639 2056 662681 SGTC_3246 9135460 32.98 µM 0.205605134544926 0.426724058326848 no 1428 0.418549683216456 1999 41446951 SGTC_1209 2323-2347 50.3 µM 0.204910721661527 0.426974283057737 no 1429 0.418820939143503 2082 5412760 SGTC_2135 5326629 150.42 µM 0.204679569727781 0.427057582867356 no 1430 0.418911241734658 1896 5020077 SGTC_1847 st056231 15 µM 0.204590569197824 0.427089656696922 no 1431 0.418946012120222 1969 5393180 SGTC_871 0574-0004 149 µM 0.202945726050513 0.427682508470299 no 1432 0.419588726828484 1928 9551173 SGTC_2353 9059630 146.67 µM 0.200358887053929 0.428615214260271 no 1433 0.420599955440014 2026 4779114 SGTC_210 3551-0445 56.827 µM 0.200097115263707 0.428709620511925 no 1434 0.420702314715415 2010 2865180 YOR207C RET1 SGTC_2816 7982706 58.44 µM 0.198952743248163 0.42912237847859 no 1435 0.421149855478024 1923 2981853 SGTC_818 4072-2707 53.5 µM 0.198471497099907 0.429295979985934 no 1436 0.421338091589345 1960 882871 SGTC_909 3448-9333 149 µM 0.198269883756559 0.429368712697672 no 1437 0.421416956604414 1894 3344074 SGTC_1832 st054113 55 µM 0.198044741471504 0.429449936390399 no 1438 0.421505029152495 2075 1251267 SGTC_1228 0124-0032 52.5 µM 0.197381353025839 0.429689281772469 no 1439 0.421764560354461 2027 X1228 SGTC_189 3970-0742 2.116 µM 0.196299938829457 0.430079502954981 no 1440 0.422187704632893 2063 2891807 SGTC_2961 9083290 32.55 µM 0.195913777333948 0.430218863354674 no 1441 0.422338826741311 2049 17741490 SGTC_3256 9138902 49.47 µM 0.194708548538088 0.430653869762625 no 1442 0.422810559616687 2019 17228773 SGTC_2018 5133068 143 µM 0.19442417420346 0.430756522032068 no 1443 0.422921881391403 1956 785362 SGTC_250 brefeldin a 552.239 µM 0.194063625921165 0.430886677983153 no 1444 0.423063031227634 1967 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_820 1582-0060 59.9 µM 0.191964261147587 0.431644685816108 no 1445 0.423885100108302 1946 3848840 SGTC_1668 st014914 51.6 µM 0.190280814951094 0.432252701901419 no 1446 0.424544543227145 2045 2839556 SGTC_1163 k060-0048 49.9 µM 0.187185385120486 0.433371106821559 no 1447 0.425757641648887 2023 6809982 SGTC_1484 3473-2379 286 µM 0.187161564941229 0.433379715334377 no 1448 0.425766979513531 2087 671917 SGTC_1494 4358-1428 177 µM 0.185709983815075 0.433904370162043 no 1449 0.426336099284759 2122 1564571 SGTC_2858 9025781 8.96 µM 0.184759583738361 0.434247942867236 no 1450 0.426708804760034 2075 4894980 YPL153C RAD53 SGTC_2328 6201408 200 µM 0.184255480619473 0.434430197954302 no 1451 0.42690651861134 1951 2890418 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.183478306042031 0.434711207480401 no 1452 0.427211369550101 1889 23665772 A membrane-active detergent. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.183068610297246 0.434859357891602 no 1453 0.427372092436276 2053 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1749 st037932 54.2 µM 0.183059334126344 0.434862712361266 no 1454 0.427375731600699 1963 594497 SGTC_3288 9119690 36.221 µM 0.182672884808541 0.435002465191251 no 1455 0.427527346262467 1922 17595618 YKL019W RAM2 SGTC_2152 5568786 200 µM 0.18077754975071 0.435687998166099 no 1456 0.428271092730637 2036 5399883 SGTC_2902 5787006 60.46 µM 0.179827369751052 0.436031746272884 no 1457 0.428644047959237 1961 591003 SGTC_1493 4348-0038 111 µM 0.178030568222141 0.436681909869969 no 1458 0.429349484616793 2052 800424 SGTC_2035 5154463 94.595 µM 0.176471416806204 0.4372462196721 no 1459 0.429961801174301 2083 2769623 SGTC_2419 paclitaxel 166.5 µM 0.175949325429001 0.437435210851788 no 1460 0.430166876844309 1956 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3350 9150499 3.57 µM 0.17585292604548 0.437470107902015 no 1461 0.430204744247579 2063 4910996 YPR165W RHO1 SGTC_3035 9091303 49.47 µM 0.174785056590176 0.437856714368521 no 1462 0.430624265348819 2059 25237002 SGTC_1152 3909-8331 15.9 µM 0.173420067265348 0.438350975059907 no 1463 0.431160626341096 1961 16001939 SGTC_411 enrofloxacin 100 µM 0.171773816344565 0.438947208050213 no 1464 0.431807675529817 2134 71188 A bacterial gyrase inhibitor. SGTC_954 1189-0853 2.85 µM 0.171385526316162 0.439087857722614 no 1465 0.431960317364173 2110 2828194 SGTC_2434 5670830 169.91 µM 0.171057977743754 0.439206511096267 no 1466 0.432089088846036 1987 1549830 SGTC_530 4358-1714 28 µM 0.170902100890585 0.439262978883379 no 1467 0.432150372348056 2043 1564641 SGTC_106 0092-0003 11.579 µM 0.169588318382806 0.439738957368312 no 1468 0.432666955025069 2108 1072148 SGTC_665 3914-0008 307 µM 0.169208067551206 0.439876737108218 no 1469 0.432816492152373 1999 1069549 SGTC_734 2023-0417 80 µM 0.168952262473228 0.439969429385213 no 1470 0.432917095260527 2045 3935732 SGTC_300 r073-0011 5.04 µM 0.168709726195548 0.440057316683583 no 1471 0.433012484026074 2142 2735780 SGTC_1618 st003135 44.5 µM 0.167476791896337 0.440504137757526 no 1472 0.433497453500589 2106 1270615 SGTC_1963 st076565 50.3 µM 0.166018076163703 0.441032880872178 no 1473 0.434071362427399 2017 4914280 SGTC_1179 1021-1431 9.29 µM 0.165653871120217 0.441164911316785 no 1474 0.434214674946179 2038 2840958 SGTC_430 0958-0115 16.4 µM 0.163026150885671 0.442117696934562 no 1475 0.435248922340076 1951 6833180 SGTC_3086 9117350 49.47 µM 0.161860216341234 0.442540560989969 no 1476 0.435707966193251 2111 2679265 SGTC_2465 5809242 33.21 µM 0.160860119352561 0.442903330849652 no 1477 0.43610178665999 2053 2731748 SGTC_220 paclitaxel 373.376 µM 0.159775976503524 0.443296641123376 no 1478 0.436528774456709 2109 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2058 5236698 133 µM 0.1592954560862 0.443470984399127 no 1479 0.436718050283914 2021 766665 SGTC_2861 9024595 19.48 µM 0.159270369233828 0.443480086756554 no 1480 0.436727932332556 2136 16482810 SGTC_2539 epi(13)torulosol 80 µM 0.159057123043002 0.443557460881317 no 1481 0.43681193446961 1983 6708597 SGTC_765 1319-0117 244 µM 0.155684406555025 0.444781499637119 no 1482 0.438140894527385 2145 3487746 YGL099W LSG1 SGTC_2455 5377712 9.75 µM 0.154654555174998 0.4451553626269 no 1483 0.438546829272087 1939 2243908 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.154312299877778 0.445279621069568 no 1484 0.438681749788674 2119 165506 SGTC_1434 4073-0095 163 µM 0.153803297755708 0.445464428181152 no 1485 0.438882416772909 2117 24133745 SGTC_3031 9088762 49.47 µM 0.153681147753316 0.445508779837907 no 1486 0.438930575046257 2123 205253 SGTC_1211 1056-0033 32.3 µM 0.152991650035377 0.445759143536652 no 1487 0.43920243003903 2151 6741922 SGTC_1252 0493-0875 34.8 µM 0.152906505548121 0.445790061876428 no 1488 0.439236002778748 2032 3960963 SGTC_2281 7943571 200 µM 0.151647521582642 0.446247272470087 no 1489 0.439732475011477 2184 1244024 SGTC_138 0850-0259 40.9225 µM 0.151236472922945 0.446396563747985 no 1490 0.439894589972834 2144 6813004 SGTC_752 1896-0090 130 µM 0.150764013834223 0.446568168440042 no 1491 0.440080937262113 2097 772567 SGTC_1609 st001574 46.4 µM 0.150277330071042 0.446744950223934 no 1492 0.440272908925777 2044 3960012 SGTC_2825 7998094 58.44 µM 0.14918906989577 0.447140285347962 no 1493 0.440702222216358 2060 2987815 SGTC_2949 9072542 2.23 µM 0.14879388550239 0.447283858039042 no 1494 0.440858137796039 2021 16457352 SGTC_1441 4106-0040 13 µM 0.147539916416208 0.447739477642154 no 1495 0.441352937853262 2137 2904180 SGTC_2840 9008771 71.43 µM 0.147398192414995 0.447790976269171 no 1496 0.441408866091996 2142 2992978 SGTC_3066 9117245 49.47 µM 0.147285631735918 0.447831878369397 no 1497 0.441453286503953 2082 17176980 SGTC_1109 tnp00067 928.257 nM 0.146937457042215 0.447958400982707 no 1498 0.441590693171592 2005 676295 SGTC_2057 5236571 38.335 µM 0.146532021716101 0.448105738111949 no 1499 0.441750706527689 2129 54684039 YBR257W POP4 SGTC_1380 2291-0730 164 µM 0.146426619645267 0.448144042900042 no 1500 0.44179230717194 2009 2999191 SGTC_2368 9071271 200 µM 0.143989282992509 0.449029943923359 no 1501 0.442754466189861 2017 27209959 SGTC_2785 7756463 72.73 µM 0.143228056246522 0.449306680012357 no 1502 0.44305503628533 2072 2201551 SGTC_1672 st016598 6.51 µM 0.142420194797679 0.449600396633768 no 1503 0.443374055917695 1999 4665860 YNL267W PIK1 SGTC_1183 1254-0324 198 µM 0.139038315744703 0.450830254527889 no 1504 0.444709935750946 2118 5799357 SGTC_575 k072-0246 11.9 µM 0.137941425123534 0.45122925298184 no 1505 0.445143355408028 2119 6796779 SGTC_380 3970-0968 6 µM 0.136384388950199 0.451795715796291 no 1506 0.445758707087201 2075 2891601 SGTC_807 1315-0151 48 µM 0.134123921412631 0.452618267227724 no 1507 0.446652291996823 2192 4011080 SGTC_1008 4106-0037 6 µM 0.134063258271366 0.452640344485127 no 1508 0.446676276482877 2109 2905394 SGTC_3188 9110789 49.47 µM 0.133548956543022 0.452827521209595 no 1509 0.446879624632356 2160 849217 SGTC_78 0336-0123 156.75 µM 0.131517668199661 0.453566897279261 no 1510 0.447682905383832 1971 6765896 SGTC_1326 1431-2094 10.8 µM 0.130627994581954 0.453890783675416 no 1511 0.448034798001146 2090 616278 SGTC_1025 k007-0731 70 µM 0.129439460523806 0.45432351826861 no 1512 0.448504962657766 1983 6256118 SGTC_2204 7233102 200 µM 0.129271290233815 0.454384751953887 no 1513 0.448571493933972 2124 2172480 SGTC_2750 bromebric acid 70.15 µM 0.128905901141358 0.454517800120531 no 1514 0.448716053597843 2086 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1063 disulfiram 1.84 µM 0.12659629507965 0.455358908351589 no 1515 0.449629964723057 2186 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2363 9053361 176 µM 0.126361708205566 0.455444351042362 no 1516 0.449722805781315 2177 6469797 YMR079W SEC14 SGTC_290 2043-6722 48.1 µM 0.126281451536891 0.455473583098904 no 1517 0.449754569119996 2155 773758 YLR208W SEC13 SGTC_1778 st046819 58.9 µM 0.125166668187341 0.455879647861404 no 1518 0.450195802307654 2128 671715 SGTC_2097 5376186 200 µM 0.123931292889353 0.456329692595664 no 1519 0.450684837897562 2170 742755 SGTC_2867 9039098 71.43 µM 0.123220982345686 0.456588482702852 no 1520 0.450966055336754 2180 6463460 SGTC_253 dyclonine 31.25 µM 0.120995320002979 0.45739948536286 no 1521 0.451847371028876 2160 3180 An oral anasthetic. SGTC_3240 9133527 49.47 µM 0.12087788049754 0.457442283762164 no 1522 0.451893881244964 2088 17617455 SGTC_485 niflumic acid 177 µM 0.120700474171371 0.457506936765013 no 1523 0.451964141704164 2162 4488 A COX2 inhibitor. SGTC_495 decylubiquinone 155 µM 0.120387989712301 0.457620819646524 no 1524 0.452087902513255 2055 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1637 st007924 17.4 µM 0.119876916252456 0.457807084463009 no 1525 0.452290325376118 2171 683336 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.119394900546998 0.457982767440755 no 1526 0.452481250585877 2181 4620898 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.118132937909034 0.458442760862466 no 1527 0.452981162746566 2034 641818 YHR062C RPP1 SGTC_42 0133-0086 60.653 µM 0.118047394824347 0.458473943883037 no 1528 0.4530150523738 2178 162923 Model of phenazepam hydroxylation. SGTC_1799 st045822 46.1415 µM 0.117016854879576 0.45884962663687 no 1529 0.453423348489554 2196 3674992 SGTC_1936 st074407 74.3 µM 0.11519779056196 0.459512854999385 no 1530 0.454144174947696 2143 809813 SGTC_446 go6976 132 µM 0.114987148013462 0.459589662299591 no 1531 0.454227654435002 2210 3501 A protein kinase C inhibitor. SGTC_814 3342-0569 96 µM 0.11425597079998 0.459856285589463 no 1532 0.454517442037757 2202 4346283 SGTC_1605 st000082 49.1 µM 0.114171235288632 0.459887185507542 no 1533 0.454551026847274 2165 1114022 SGTC_2910 7948405 25.97 µM 0.113518333273204 0.460125282921557 no 1534 0.45480981458931 2180 2971328 SGTC_3026 9090633 49.47 µM 0.111785092085242 0.460757422776729 no 1535 0.455496904111587 2145 25236842 SGTC_1231 0242-0792 125 µM 0.111352879406721 0.460915072934402 no 1536 0.455668262194355 2105 3707635 SGTC_523 1934-0222 13.7 µM 0.111144467547071 0.460991093638183 no 1537 0.455750893577344 2083 1361595 SGTC_1997 st073024 93.8 µM 0.110811234920577 0.46111264716158 no 1538 0.45588301802248 2228 686268 SGTC_3314 9135860 59.4275 µM 0.110412008102449 0.461258278220229 no 1539 0.4560413151335 2205 25252478 SGTC_1419 3993-2473 62.6 µM 0.10985258905947 0.46146235337636 no 1540 0.456263141671102 2129 704026 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.108319979939204 0.462021498513833 no 1541 0.456870937082375 2075 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_856 0433-0016 11.3 µM 0.108055577356963 0.462117968709284 no 1542 0.456975802945617 2124 3911780 SGTC_132 0417-1715 25.805 µM 0.107048020876121 0.462485607171833 no 1543 0.457375441723126 2231 6769098 SGTC_1262 0737-0114 49.6 µM 0.105337435288853 0.463109840999387 no 1544 0.458054029566604 2230 765919 SGTC_414 piperonyl butoxide 100 µM 0.105315220617326 0.463117948268276 no 1545 0.458062842916444 2090 5794 A potent inhibitor of cytochrome P450. SGTC_1567 st069303 68.4 µM 0.101837197526877 0.464387443441275 no 1546 0.459442949882148 2118 5581319 SGTC_324 1315-0088 19.6 µM 0.0986940308501017 0.465535026720582 no 1547 0.460690604209275 2214 6787421 SGTC_1962 st076595 64.5 µM 0.0986567796194667 0.465548629038146 no 1548 0.460705393126002 2208 279619 SGTC_3198 9112019 49.47 µM 0.0979941267100426 0.465790604005851 no 1549 0.460968478564126 2191 45595555 SGTC_2074 5212007 75.395 µM 0.0977581267769269 0.465876785025265 no 1550 0.461062179025954 2243 758611 SGTC_1951 sophoraflavanone G 9.2 µM 0.0969890420032614 0.4661576458064 no 1551 0.461367548317817 2138 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1440 4100-1550 40 µM 0.0967404550308293 0.466248430477969 no 1552 0.461466256007046 2210 742806 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0951604597312232 0.466825490128179 no 1553 0.462093687988904 2236 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0928540838119856 0.467667969708991 no 1554 0.463009741946825 2140 688667 SGTC_2336 9001819 198.65 µM 0.0914503357968167 0.468180805940581 no 1555 0.463567383547097 2200 2989602 SGTC_2822 7994718 71.43 µM 0.0913211630939969 0.468227999727634 no 1556 0.463618701265425 2248 1018011 SGTC_2339 9000433 200 µM 0.0901886807083753 0.468641775946813 no 1557 0.464068639577718 2114 2988954 SGTC_1964 st076914 61 µM 0.0888564167399756 0.469128589895768 no 1558 0.464598010443634 2264 24208661 SGTC_890 0929-0006 47.2 µM 0.0875490593724221 0.469606347760424 no 1559 0.465117545680524 2099 1378169 SGTC_2512 diallyl trisulfide 49.23 µM 0.0873728129675898 0.469670758230175 no 1560 0.46518758941332 2264 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1560 lithocholic acid 53.1 µM 0.0872824388974916 0.46970378636817 no 1561 0.465223506236586 2242 9903 A bile acid which acts as a detergent. SGTC_1627 st003713 25.6 µM 0.0868453030665838 0.469863545114253 no 1562 0.465397238495586 2153 16195070 YER133W GLC7 SGTC_1423 4048-0112 5.59 µM 0.0865937998818397 0.46995546344349 no 1563 0.465497197183156 2261 X1423 SGTC_2445 5742597 35.57 µM 0.0860772513469526 0.470144254451367 no 1564 0.465702503644704 2161 1774255 SGTC_865 0488-0499 301 µM 0.0853554404974072 0.470408077094477 no 1565 0.465989408579315 2261 9634651 SGTC_754 3474-0146 171 µM 0.0826308519017538 0.471404033253002 no 1566 0.46707253444205 2179 24762078 SGTC_1377 2944-0135 198 µM 0.0825712321959532 0.471425828882491 no 1567 0.467096238260572 2204 1894137 SGTC_2259 7964009 200 µM 0.0825195978875733 0.471444705298643 no 1568 0.467116767310168 2201 313134 SGTC_2990 9074105 71.4286 µM 0.0825148259189381 0.471446449833157 no 1569 0.467118664579869 2275 6502001 SGTC_619 1652-1634 108 µM 0.0824920038815799 0.471454793112636 no 1570 0.467127738321252 2167 5400454 SGTC_550 4123-0385 25.7 µM 0.0812841482279221 0.471896378719663 no 1571 0.467607990076865 2194 5731123 SGTC_460 trequinsin 123 µM 0.0797451740123548 0.472459069496407 no 1572 0.468219965083657 2262 5537 A vasodilator. SGTC_483 fpl-64176 144 µM 0.0783595147671278 0.472965751215401 no 1573 0.468771038501733 2255 3423 SGTC_832 4083-0019 164 µM 0.0781903677128778 0.473027604729923 no 1574 0.468838312005947 2229 1990758 SGTC_563 tetrahydrosecaminediol 614 µM 0.0772658907338035 0.473365677938368 no 1575 0.469206012506617 2266 334274 A psychoactive constituent of the cannabis plant. SGTC_3163 9099914 49.47 µM 0.0769114447422873 0.473495300862571 no 1576 0.469346996464984 2265 16268368 SGTC_2784 7567673 72.73 µM 0.0741769140688628 0.474495427669411 no 1577 0.470434807569755 2273 3471247 SGTC_521 r062-0005 13.8 µM 0.0741645609955237 0.474499946049931 no 1578 0.470439722195981 2240 2832033 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.073755166200506 0.474649692132983 no 1579 0.470602600999671 2185 6857784 SGTC_2635 hydroquinidine 100 µM 0.0737502185808791 0.474651501866894 no 1580 0.470604569453378 2237 442912 An experimental heart treatment. SGTC_3101 9120531 49.47 µM 0.0736530607982528 0.474687040220968 no 1581 0.470643224671771 2276 24824904 SGTC_794 k038-0031 316 µM 0.0734719591683297 0.474753284075926 no 1582 0.470715278547195 2261 6624242 SGTC_2972 9093619 59.92 µM 0.0733682370260949 0.474791224162383 no 1583 0.470756546317918 2185 25236256 SGTC_1737 st035557 69.7 µM 0.0723453712377338 0.475165386128967 no 1584 0.471163529120174 2294 5716916 SGTC_3058 9093861 49.47 µM 0.071797769276161 0.475365706697218 no 1585 0.471381424050208 2241 17217477 SGTC_392 N-ethylmaleimide 8.33 µM 0.0717499865378691 0.475383186597064 no 1586 0.471400437567689 2223 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_635 k038-0028 24.7 µM 0.0709537282038916 0.475674481077019 no 1587 0.471717291082948 2211 4035102 SGTC_1199 1638-0010 4.46 µM 0.0708413427786295 0.475715595988081 no 1588 0.471762013840814 2229 3111136 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0700095149081878 0.476019918627013 no 1589 0.47209304321014 2231 4174840 SGTC_1827 berberine 7.24 µM 0.069523096664252 0.476197880306133 no 1590 0.472286624325665 2228 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_706 4262-0057 46.9 µM 0.0692404625615951 0.476301287409002 no 1591 0.472399107954033 2275 883298 SGTC_1715 st032160 10.2275 µM 0.0690234833938719 0.476380674479025 no 1592 0.472485463514553 2246 5289825 SGTC_1264 0783-0040 158 µM 0.0689056691959688 0.47642378004225 no 1593 0.472532352940913 2233 2855798 SGTC_3295 9122362 53.5725 µM 0.0683305718739549 0.476634199158929 no 1594 0.47276124407923 2191 4730473 SGTC_1470 k295-0292 231 µM 0.0679335890465084 0.476779452771965 no 1595 0.472919250156183 2273 5045612 SGTC_283 0987-0079 11.7 µM 0.0669163466902508 0.47715166962755 no 1596 0.473324149715012 2261 411556 SGTC_1807 st050092 58.9 µM 0.0668330830814989 0.477182137313779 no 1597 0.473357292894111 2224 5008496 SGTC_540 1187-0821 17.3 µM 0.0665852007074048 0.477272842823622 no 1598 0.473455963860708 2186 847520 SGTC_893 0958-0369 48.9 µM 0.0663706650985251 0.477351346983136 no 1599 0.47354136227567 2300 6819948 SGTC_944 3370-0224 231 µM 0.0659096327489631 0.477520053681528 no 1600 0.473724885718183 2252 4580514 SGTC_475 α-linolenic acid 10 µM 0.0655699287874022 0.477644364964935 no 1601 0.473860115462216 2279 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2065 5221596 34.26 µM 0.0655622608995347 0.477647170977325 no 1602 0.473863167938667 2252 788581 SGTC_2367 9070478 135.38 µM 0.0655499575990381 0.477651673290347 no 1603 0.473868065709769 2276 572802 SGTC_2589 lobaric acid 100 µM 0.06347360741526 0.478411540574248 no 1604 0.474694687542898 2231 73157 A novel microtubule depolymerizer. SGTC_3006 9075424 71.4286 µM 0.0630570563393287 0.478563992384173 no 1605 0.474860535142811 2234 7465181 SGTC_2331 7980721 200 µM 0.0624105594689187 0.478800607310104 no 1606 0.475117943057041 2248 2981221 SGTC_993 3909-8757 62.7 µM 0.0600449451197175 0.479666474506736 no 1607 0.476059919107365 2239 4288324 YLR208W SEC13 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.059328862835779 0.47992859557507 no 1608 0.476345086190275 2306 88881 An O-methylated flavonoid and antioxidant. SGTC_1399 3562-5772 25 µM 0.058896556938445 0.480086844843625 no 1609 0.476517250229053 2294 23847490 SGTC_1690 st023502 41.2 µM 0.0588632289799969 0.48009904495829 no 1610 0.476530523133315 2307 24207482 SGTC_265 mycophenolic acid 32.932 µM 0.0576648734695296 0.480537730229843 no 1611 0.47700778701323 2272 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1629 st005085 44.9 µM 0.0574983457642647 0.480598693358751 no 1612 0.47707411190965 2255 24207091 SGTC_328 k915-0120 63.5 µM 0.0564813565134514 0.480971006649227 no 1613 0.477479173580315 2297 6624543 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0557686171017013 0.481231945922993 no 1614 0.47776306797259 2283 364106 SGTC_881 0833-0569 170 µM 0.0540401605242013 0.481864780087509 no 1615 0.478451583750518 2219 5418700 SGTC_1817 st052116 64.4 µM 0.0530761293932459 0.482217757612875 no 1616 0.478835625311459 2292 4361398 SGTC_2118 5526350 200 µM 0.0529872684780195 0.482250294514895 no 1617 0.47887102587301 2261 743594 SGTC_1707 st032323 6.317 µM 0.0500126309864494 0.48333954089651 no 1618 0.480056161423537 2268 3132057 YMR211W DML1 SGTC_2261 9010538 184.68 µM 0.0496638700200486 0.483467257741176 no 1619 0.480195124229407 2174 6457250 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0496431959653552 0.483474828667702 no 1620 0.480203361822886 2236 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1172 0370-0043 85 µM 0.0494425682024024 0.4835482997146 no 1621 0.480283302552643 2266 376585 SGTC_2736 butenafine 14.65 µM 0.0492030617198862 0.483636009104693 no 1622 0.480378735662118 2286 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2093 5331342 194.4 µM 0.0472848323320575 0.484338509866417 no 1623 0.481143108303171 2320 33839 SGTC_2335 9018011 154.17 µM 0.045857437221688 0.484861287228974 no 1624 0.481711939320271 2294 6458208 SGTC_2676 harmalol 100 µM 0.0457669630666095 0.484894423888252 no 1625 0.481747995429625 2321 5459187 A monoamine oxidase inhibitor SGTC_7 0192-1582 4.227 µM 0.0431732449735316 0.485844430938362 no 1626 0.482781716307301 2310 252616 SGTC_1461 k072-0203 53.8 µM 0.0417119189892696 0.486379709875538 no 1627 0.483364176126138 2319 5418714 SGTC_298 1391-0729 10 µM 0.0405977919616956 0.486787827506925 no 1628 0.483808272233233 2306 3237558 SGTC_450 aminopyrene 156 nM 0.0398555295200869 0.487059734541203 no 1629 0.484104152606208 2330 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3244 9134489 49.47 µM 0.0390388467344791 0.487358910327589 no 1630 0.484429708495849 2241 16584271 SGTC_2591 skatole 100 µM 0.0382033326248932 0.48766499196237 no 1631 0.484762781893466 2296 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_806 3966-4455 5.86 µM 0.0362849555453336 0.488367796033179 no 1632 0.485527572888238 2193 714982 SGTC_1769 st044406 64.4 µM 0.0342118050280333 0.48912734243336 no 1633 0.486354126500701 2314 670903 SGTC_1076 itraconazole 331 nM 0.033591869598438 0.489354477828063 no 1634 0.486601302865737 2348 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_763 3453-1109 128 µM 0.0327158551654303 0.48967544274288 no 1635 0.486950590032895 2346 1560353 SGTC_1365 1672-3266 55.4 µM 0.0321838714193838 0.489870360750353 no 1636 0.487162709129746 2337 6415873 SGTC_3069 9117009 49.47 µM 0.031932985569769 0.489962285773202 no 1637 0.4872627466828 2349 41904981 SGTC_823 0417-1665 178 µM 0.0318305774475837 0.489999808445366 no 1638 0.487303580854398 2304 3429856 SGTC_2707 st078556 66.6 µM 0.0315220321119133 0.490112861002953 no 1639 0.487426610894793 2347 17250899 SGTC_1188 1403-0014 4.57 µM 0.0304776065326089 0.49049554961196 no 1640 0.487843076240841 2336 9614867 SGTC_1128 3448-9350 235 µM 0.0301852331688337 0.490602679895823 no 1641 0.487959662695083 2257 619386 SGTC_2700 st077718 96.8 µM 0.0300638042994027 0.490647173578373 no 1642 0.48800808382938 2322 904970 SGTC_3025 9087895 49.47 µM 0.0299408681441772 0.490692219675614 no 1643 0.488057106190994 2350 17173641 SGTC_1891 st059073 26.2 µM 0.0288377568511676 0.491096425444782 no 1644 0.48849699388997 2360 688754 SGTC_1594 piperine 70.1 µM 0.0274144804894941 0.49161796063047 no 1645 0.489064574414655 2368 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_185 k048-0037 25.491 µM 0.0270599150732412 0.491747887303784 no 1646 0.489205973090537 2356 6827589 SGTC_2482 5981709 142.65 µM 0.0257145775417814 0.49224087958137 no 1647 0.489742498252596 2352 877755 SGTC_1860 st056228 74.6 µM 0.0257090643902044 0.492242899873368 no 1648 0.48974469695496 2276 688679 SGTC_2373 9071805 200 µM 0.0256964072269388 0.492247538086095 no 1649 0.489749744764892 2365 10149009 SGTC_2001 4023502 57.655 µM 0.025286176485248 0.492397867551354 no 1650 0.489913349986866 2335 108941 YCR052W RSC6 SGTC_1412 3909-8563 178 µM 0.0247751479753213 0.492585135967332 no 1651 0.490117157007728 2363 23767530 SGTC_2147 5545932 89.7195 µM 0.0244595268015958 0.492700797412109 no 1652 0.490243033490805 2335 797404 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.023679137354709 0.49298677884638 no 1653 0.490554273659581 2369 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2894 9048625 32.47 µM 0.0233307298278761 0.493114457404524 no 1654 0.490693229761475 2359 4092861 SGTC_162 k030-0015 37.8 µM 0.0233174802881589 0.49311931288805 no 1655 0.490698514125484 2363 1809920 YMR134W ERG29 SGTC_3160 9100216 49.47 µM 0.02239138526461 0.493458696153494 no 1656 0.49106787609674 2378 17191039 SGTC_2381 9035592 200 µM 0.0219945150084455 0.493604137469496 no 1657 0.49122616543503 2277 4749657 SGTC_1661 st013063 9.66 µM 0.0152271353700123 0.496084298681122 no 1658 0.49392548663758 2383 721395 SGTC_3183 9108214 49.47 µM 0.0146255693637509 0.496304773940848 no 1659 0.494165450015383 2377 4974831 SGTC_1181 1222-0449 220 µM 0.0142967418341204 0.496425290432536 no 1660 0.494296619503193 2373 658318 SGTC_3104 9120930 49.47 µM 0.013836499580791 0.49659397144627 no 1661 0.494480211431104 2335 17014836 SGTC_572 0960-0087 17.7 µM 0.0135551841497279 0.496697075215299 no 1662 0.494592429525106 2372 6796365 SGTC_3079 9117512 49.47 µM 0.0134209059577547 0.496746289044914 no 1663 0.494645993900545 2388 7185044 SGTC_3061 glucosamine 200 µM 0.0125787469639208 0.497054946885867 no 1664 0.494981938332333 2371 91431 and experimental redox chemotherapeutic SGTC_3156 9099931 49.47 µM 0.012231419450737 0.497182245652986 no 1665 0.495120491300695 2379 18111053 SGTC_2883 9059145 45.46 µM 0.0121414942951269 0.497215204106979 no 1666 0.495156363583537 2381 16476510 SGTC_56 0957-0365 83.25 µM 0.0120011869120482 0.497266628180755 no 1667 0.495212334052774 2375 6752360 SGTC_2863 9028737 58.44 µM 0.0114674998907483 0.497462230274879 no 1668 0.495425229709727 2389 6460917 SGTC_2228 7354201 200 µM 0.0107117199111702 0.497739232884798 no 1669 0.495726723751731 2356 753451 SGTC_1106 tegaserod maleate 11.7 µM 0.0105067065435226 0.497814372986025 no 1670 0.49580850764925 2324 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2156 5649887 115 µM 0.00980871155773121 0.498070197912937 no 1671 0.496086952989705 2371 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3161 9100388 49.47 µM 0.00881091365377062 0.49843590615536 no 1672 0.49648499949414 2388 25236368 SGTC_1981 st071826 47 µM 0.0074625533192686 0.498930102938743 no 1673 0.497022899593525 2352 11838600 SGTC_3258 9138477 49.47 µM 0.00593028644014016 0.499491706520818 no 1674 0.497634171871169 2393 4970355 SGTC_1438 4092-1045 4 µM 0.00574217047748799 0.499560654522405 no 1675 0.497709218004074 2394 1351342 SGTC_1097 itavastatin 7.23 µM 0.00571411253242124 0.49957093828267 no 1676 0.497720411321025 2397 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1206 3978-0017 132 µM 0.00501166451079636 0.49982839866127 no 1677 0.498000643501026 2379 3873677 SGTC_1506 4226-2149 212 µM 0.00481643899574928 0.499899952492448 no 1678 0.498078526272709 2369 991114 SGTC_1035 k081-0041 55.2 µM 0.00427050525842482 0.499899952492448 no 1679 0.498296320072135 2398 731709 SGTC_2995 9067767 71.4286 µM 0.00306129951489641 0.499456755935014 no 1680 0.498778720098084 2394 11673567 SGTC_226 1,3-diallylurea 8.28947 mM 0.0013439616588784 0.498827320723282 no 1681 0.499463837032441 2396 74537 YKL182W FAS1 SGTC_200 k038-0079 37.545 µM -0.000146594038772417 0.498281007561917 no 1682 0.499941517440088 2406 3436683 SGTC_776 4476-4378 112 µM -0.000598413166004964 0.498115409015532 no 1683 0.49976126770118 2407 2892008 SGTC_2488 5268135 45.7 µM -0.00104132998303542 0.497953073615542 no 1684 0.499584569516997 2409 1270356 YLR208W SEC13 SGTC_3316 9136639 10.545 µM -0.00130103120180954 0.497857889530057 no 1685 0.499480963791904 2413 4903665 SGTC_1373 2887-0003 58.5 µM -0.0015609341757594 0.4977626316206 no 1686 0.499377277613245 2413 776948 SGTC_2667 digitoxin 100 µM -0.00191786271042474 0.497631812756909 no 1687 0.499234883945848 2407 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2806 7952793 58.44 µM -0.00196325528740697 0.497615175816026 no 1688 0.499216774961772 2411 2972490 SGTC_1047 2043-3044 82 µM -0.00262895047421362 0.497371190788246 no 1689 0.498951201710862 2409 669592 SGTC_2265 7929201 200 µM -0.00307558846772107 0.497207493314933 no 1690 0.498773019657496 2411 1265108 SGTC_714 4296-0578 26.1 µM -0.00311764752158107 0.497192078257729 no 1691 0.498756240603086 2413 1589775 SGTC_1453 4237-0541 195 µM -0.00345464524347365 0.497068565429087 no 1692 0.498621798689965 2410 739892 SGTC_1977 st070720 65.3 µM -0.00468281059531404 0.496618433764655 no 1693 0.49813183569016 2432 682188 SGTC_3091 9116372 49.47 µM -0.00492247680450694 0.496530594814526 no 1694 0.498036223809028 2458 17169793 SGTC_2831 7999036 19.48 µM -0.00642996326687491 0.495978096975344 no 1695 0.497434833467318 2422 2988270 SGTC_2254 7938975 95.19 µM -0.00646765483818163 0.495964283007618 no 1696 0.497419797018575 2424 2969277 SGTC_2963 9082507 9 µM -0.00666660830675178 0.495891366605851 no 1697 0.497340427779766 2428 16459611 SGTC_245 methotrexate 289.6 µM -0.00769997797147342 0.495512639117482 no 1698 0.496928183583542 2418 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_101 0490-5701 117.494 µM -0.00780022686887088 0.495475898348252 no 1699 0.496888191260892 2427 4661669 SGTC_3056 9094900 49.47 µM -0.00885802961180412 0.495088220808086 no 1700 0.496466203679902 2432 25236784 SGTC_2715 st079500 56.4 µM -0.00958793721561746 0.494820717298059 no 1701 0.496175025067006 2416 28246688 SGTC_468 gf-109203x 121 µM -0.00977812314702386 0.494751016519044 no 1702 0.496099155414838 2426 2396 A protein kinase C inhibitor. SGTC_2865 9030313 51.95 µM -0.0101273660506764 0.494623023756328 no 1703 0.495959834555682 2419 42562754 SGTC_1698 5-fluorocytosine 1.055 µM -0.0106329517971482 0.494437734457416 no 1704 0.495758145893231 2426 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2078 5212016 200 µM -0.010968190912839 0.494314875203808 no 1705 0.49562441263694 2431 1899708 SGTC_3193 9111931 49.47 µM -0.0112949880512638 0.4941951103057 no 1706 0.495494047519058 2441 17087244 SGTC_3111 9122088 49.47 µM -0.0139078843221238 0.493237553540298 no 1707 0.494451735779644 2435 16876704 SGTC_1476 4112-3294 3.34 µM -0.0143752568752491 0.493066277919167 no 1708 0.494265299752245 2451 704369 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0151488511556528 0.492782785617142 no 1709 0.493956713918681 2430 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1119 parthenolide 318.541 nM -0.0152333871717922 0.492751806664082 no 1710 0.493922992818772 2488 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3178 9107506 49.47 µM -0.0153012994663568 0.492726919648992 no 1711 0.49389590289052 2450 8897194 SGTC_1843 st055809 45.5 µM -0.0153659548263549 0.492703226190483 no 1712 0.493870112165904 2484 16413835 SGTC_2299 7976368 114.88 µM -0.0166078468241588 0.492248130323221 no 1713 0.493374732281006 2452 2979718 SGTC_409 arachidonic acid 100 µM -0.0170651825614183 0.492080540479309 no 1714 0.4931923075783 2432 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_386 1509-0011 3.07 µM -0.0172234916407106 0.492022528731134 no 1715 0.493129160674277 2439 3107280 SGTC_1885 st057546 99.9 µM -0.0173358608540826 0.491981351570984 no 1716 0.49308433853623 2462 702008 SGTC_974 1326-0144 138 µM -0.0175830861960056 0.491890757329726 no 1717 0.492985724926298 2438 5411856 SGTC_1167 k781-0610 148 µM -0.017732335495708 0.491836066022701 no 1718 0.492926192352078 2449 4525169 SGTC_1040 k898-0338 155 µM -0.0187858570601682 0.491450015226254 no 1719 0.492505968132211 2435 20969351 SGTC_3155 9099265 49.47 µM -0.0189505637620763 0.491389661074399 no 1720 0.492440271360403 2460 25236499 SGTC_740 k014-0057 261 µM -0.0190047219694592 0.491369815703491 no 1721 0.49241866925201 2465 4012779 SGTC_2020 4017018 200 µM -0.0204121406111048 0.490854098273961 no 1722 0.491857299530792 2460 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3303 9125618 40.5795 µM -0.0214668622999967 0.490467628815772 no 1723 0.49143661871107 2471 22695467 SGTC_3261 9137475 49.47 µM -0.0227674416265132 0.489991084949408 no 1724 0.490917889553733 2443 17027690 SGTC_2798 7813637 45.45 µM -0.024379225006459 0.489400533041143 no 1725 0.490275059721929 2472 956368 SGTC_849 0386-0493 241 µM -0.0247556435230007 0.489262617885714 no 1726 0.490124935772594 2460 726119 SGTC_1958 st076513 41.9 µM -0.027500749011564 0.488256884567005 no 1727 0.489030171224826 2462 732122 YGL099W LSG1 SGTC_305 1682-2595 20.8 µM -0.0284769528038207 0.487899247243267 no 1728 0.488640874785825 2497 226033 SGTC_473 2-arachidonoylglycerol 10 µM -0.0300084340421535 0.487338200863017 no 1729 0.488030163404076 2443 5282280 An endocannabinoid. SGTC_2793 7325131 81.82 µM -0.0306845003103283 0.487090537088828 no 1730 0.487760576151601 2479 4176441 SGTC_272 doxorubicin 8.13 µM -0.0311488108639824 0.486920448794485 no 1731 0.487575431547593 2443 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3312 9133330 71.43 µM -0.0330513982822536 0.486223509743785 no 1732 0.486816800052636 2493 17617324 SGTC_1572 epiandrosterone 68.9 µM -0.0343106245899371 0.48576226407089 no 1733 0.486314726330698 2476 441302 A steroid. SGTC_2489 cantharidin 73.42 µM -0.0346131169376781 0.485651466081661 no 1734 0.486194120982108 2475 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3023 9089636 49.47 µM -0.034941198061184 0.48553129659575 no 1735 0.486063314676936 2458 17249241 SGTC_2593 nobiletin 86.24 µM -0.0361410054710998 0.485091842657415 no 1736 0.485584963016595 2501 72344 An anti-infammatory. SGTC_1290 0986-0249 10.2 µM -0.0370350717258521 0.484764384397339 no 1737 0.48522852085963 2469 53329 SGTC_1006 4099-6547 255 µM -0.0370862250307699 0.484745649436492 no 1738 0.485208127653278 2516 3146833 SGTC_1812 st052057 4.327 µM -0.0371915795044018 0.484707063337078 no 1739 0.485166126275536 2464 3645418 SGTC_3251 9135047 49.47 µM -0.0382848315679558 0.484306668045233 no 1740 0.484730292287777 2503 17682963 SGTC_312 4092-0653 6.84 µM -0.0386180396071195 0.484184636251209 no 1741 0.484597459747017 2556 1148278 SGTC_1283 0922-0125 16.4 µM -0.0392481109128868 0.483953887377958 no 1742 0.48434628810081 2507 3360884 SGTC_2826 7992541 19.48 µM -0.0393561180840487 0.483914332816097 no 1743 0.484303232739378 2467 2985066 SGTC_418 lividomycin a 100 µM -0.0405547526350376 0.483475377635977 no 1744 0.483825428311366 2478 72394 An antibiotic. SGTC_1713 st033146 12.748 µM -0.040705524810565 0.483420164359472 no 1745 0.48376532854297 2485 674619 SGTC_1806 st050005 60.3 µM -0.0408777338269775 0.483357101228939 no 1746 0.483696684219707 2491 5194765 SGTC_986 1493-0483 84 µM -0.0411329474603912 0.4832636424829 no 1747 0.483594954273338 2469 40079 SGTC_1804 st050076 49.1 µM -0.042264775241849 0.482849180459722 no 1748 0.483143812733124 2527 3895976 SGTC_1393 3470-5649 58.2 µM -0.0431070314647093 0.482540768138496 no 1749 0.482808107106487 2539 4108395 SGTC_629 3448-6466 76.7 µM -0.0432782929531606 0.482478057908199 no 1750 0.482739847360427 2488 573744 SGTC_1245 0418-0076 17.2 µM -0.0437290774989749 0.482312997757457 no 1751 0.482560180443902 2550 6790114 SGTC_1311 1190-0148 100 µM -0.0457649000637197 0.481567595161213 no 1752 0.481748817587238 2526 1961333 SGTC_2906 7926292 26.41 µM -0.0470852764432867 0.481084182608132 no 1753 0.481222631009236 2540 2966319 SGTC_2224 6650123 117.647 µM -0.0478015200996358 0.480821965049957 no 1754 0.480937212539366 2487 2908370 SGTC_949 1165-0505 146 µM -0.048418271991295 0.480596178176507 no 1755 0.480691448719606 2495 6244267 SGTC_2751 anetholtrithion 17.25 µM -0.0486453974699241 0.480513031310641 no 1756 0.480600945409191 2529 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1391 3442-0225 151 µM -0.0488331741520893 0.48044429002576 no 1757 0.480526122276161 2508 5227075 SGTC_898 1000-0849 28.3 µM -0.0497871368440266 0.480095072403088 no 1758 0.480146008641366 2470 6751807 SGTC_212 3807-4682 38.772 µM -0.0505522137386881 0.479815011329564 no 1759 0.479841171006859 2549 3125501 YBL034C STU1 SGTC_244 nsc-207895 1.295 µM -0.05089547865538 0.47968936033869 no 1760 0.479704404176379 2477 42640 SGTC_1784 st039334 36.3 µM -0.0517616157225589 0.479372322720523 no 1761 0.479359320372279 2602 3496984 SGTC_639 0833-0042 114 µM -0.0521773107160127 0.47922016788027 no 1762 0.479193705863818 2524 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_700 3453-2283 142 µM -0.0522955745843209 0.479176880877358 no 1763 0.479146589732025 2541 565664 SGTC_122 0236-0016 402.397 µM -0.0523925400300095 0.479141389717443 no 1764 0.479107959074359 2493 6808838 SGTC_1912 st060209 90.8 µM -0.0536319074008596 0.478687772829479 no 1765 0.478614217328586 2545 688787 SGTC_801 0866-0028 10.1 µM -0.0543953266521115 0.478408369892359 no 1766 0.478310101067846 2500 6849771 SGTC_693 4161-2696 114 µM -0.0556829039331472 0.477937155069897 no 1767 0.477797209527411 2566 805759 SGTC_3003 9075612 71.4286 µM -0.0558613697523457 0.477871844329967 no 1768 0.477726122611676 2567 6501993 SGTC_1706 st031321 9.9705 µM -0.0563387151261998 0.477697159577184 no 1769 0.477535988793006 2516 6103185 SGTC_1111 tnp00062 510.699 nM -0.0565522482746025 0.477619018411276 no 1770 0.477450936991431 2608 676306 SGTC_2253 7938677 135.83 µM -0.0584662483034243 0.476918640439037 no 1771 0.476688623219659 2620 2301972 SGTC_281 1672-3440 14.9 µM -0.0585564321402913 0.476885641777535 no 1772 0.476652706608429 2538 6833000 SGTC_2108 5365811 200 µM -0.0591468168352162 0.476669621353364 no 1773 0.476417584722035 2569 780283 SGTC_2307 7538926 6.34 µM -0.0594160920223259 0.476571096444429 no 1774 0.476310348061211 2550 96582 SGTC_2441 5730946 39.09 µM -0.0632261049824007 0.475177209801816 no 1775 0.474793228796008 2590 1774275 SGTC_959 1222-0044 107 µM -0.0632569262400515 0.475165935113682 no 1776 0.474780957457293 2535 6083612 SGTC_1734 st037168 69.4 µM -0.0633123601455386 0.475145656951749 no 1777 0.474758886768868 2605 708907 SGTC_2424 5537928 59.2 µM -0.0634009526922761 0.475113249229756 no 1778 0.474723614320314 2535 5382802 SGTC_555 4296-0685 37 µM -0.0640282169374091 0.474883796666878 no 1779 0.474473879516084 2512 2908540 YHR072W ERG7 SGTC_2047 4141938 200 µM -0.0672396375824924 0.473709194698287 no 1780 0.473195465141042 2535 3807862 SGTC_2844 9010103 25.97 µM -0.0673305747897073 0.473675936989793 no 1781 0.473159268473366 2660 2480525 SGTC_554 4483-2211 187 µM -0.0681918042466118 0.473360975832445 no 1782 0.47281647552493 2599 747107 SGTC_3149 9097855 49.47 µM -0.0683993330139814 0.473285082744605 no 1783 0.47273387638313 2596 25236625 YMR079W SEC14 SGTC_1452 4194-0072 190 µM -0.0689379770112634 0.47308810563968 no 1784 0.472519494563747 2564 1343545 SGTC_1846 st056244 14.8 µM -0.0691519672059146 0.473009853237574 no 1785 0.472434328072999 2598 5393182 SGTC_996 3970-0799 1.8 µM -0.0691712200420258 0.473002812869411 no 1786 0.472426665650521 2518 6615648 YGL040C HEM2 SGTC_97 0535-0701 19.132 µM -0.0700672500011085 0.472675162417 no 1787 0.472070066663968 2552 2832013 YGL099W LSG1 SGTC_2139 5578692 56.4705 µM -0.0724843973391228 0.4717913792007 no 1788 0.471108210962479 2523 650991 YMR113W FOL3 SGTC_2735 sertaconazole 140 nM -0.0761506217945918 0.470451161569323 no 1789 0.469649633328539 2536 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2616 abietic acid 100 µM -0.0763279204568762 0.470386356988128 no 1790 0.469579106659651 2542 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1651 st011928 86.1 µM -0.0763853839704342 0.470365353619803 no 1791 0.469556248766361 2626 720198 SGTC_1329 1447-1697 50.6 µM -0.0764327046586429 0.470348057596197 no 1792 0.469537425571504 2656 2840515 SGTC_3165 9101544 49.47 µM -0.0769447957265092 0.470160888518881 no 1793 0.469333730658512 2601 5002184 SGTC_2166 5933061 31.504 µM -0.0774313039217556 0.469983076077064 no 1794 0.469140219300928 2849 2877375 SGTC_2711 st079103 59.1 µM -0.0780108876248537 0.469771253558669 no 1795 0.46890969615788 2619 54693780 SGTC_1986 st071812 45 µM -0.078082518313172 0.469745075028857 no 1796 0.468881206549214 2555 11838594 SGTC_1798 st045719 60.953 µM -0.0786469911793772 0.469538784377728 no 1797 0.468656704855466 2538 3980186 SGTC_2176 5809774 33.9695 µM -0.0786560592438209 0.469535470455224 no 1798 0.468653098393327 2587 2870539 SGTC_3050 9093513 49.47 µM -0.0797780963682796 0.469125438549514 no 1799 0.46820687267663 2563 25236664 SGTC_1725 st036284 20.55 µM -0.0800488340056935 0.469026506363117 no 1800 0.468099208316959 2602 707914 SGTC_3142 9086498 49.47 µM -0.0802420350895058 0.468955908535127 no 1801 0.46802237938008 2560 25236367 SGTC_3287 9117173 37.0625 µM -0.0802938645538499 0.468936969637513 no 1802 0.468001768918469 2544 2789709 SGTC_2030 5175110 200 µM -0.0814519470768536 0.468513815503307 no 1803 0.467541269258724 2644 2831986 SGTC_829 1635-0120 117 µM -0.0817701570526176 0.468397550320717 no 1804 0.467414743900706 2643 285054 SGTC_1080 nisoldipine 24.4 µM -0.0823445896526387 0.468187675261914 no 1805 0.46718634868789 2543 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3289 9119912 71.43 µM -0.0826207667752258 0.468086774157059 no 1806 0.46707654411497 2612 17014829 SGTC_723 4182-0001 115 µM -0.0832443127529573 0.467858969650979 no 1807 0.466828639253023 2576 744821 YLR208W SEC13 SGTC_1695 st026914 34.495 µM -0.0837148796160418 0.467687061062146 no 1808 0.466641563226015 2549 3289191 SGTC_2650 prasterone 100 µM -0.0837546823261033 0.467672520518829 no 1809 0.466625739812488 2547 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_942 3253-1115 227 µM -0.0841216559664517 0.467538461427836 no 1810 0.466479853348698 2646 46497897 SGTC_790 1575-0012 79.1 µM -0.0851191663470382 0.467174079694535 no 1811 0.466083326531355 2542 378741 YLR208W SEC13 SGTC_2788 5282734 71.43 µM -0.0867324236947382 0.466584829380832 no 1812 0.46544210156979 2636 743706 SGTC_11 0438-0307 1.3 µM -0.087031111610504 0.46647574012218 no 1813 0.465323391217627 2636 4011476 SGTC_1645 Cervolide 78 µM -0.0874176394230582 0.466334572993123 no 1814 0.465169774409867 2626 23173 A fragrance. SGTC_2177 5811945 192 µM -0.0881127682217631 0.46608070972707 no 1815 0.464893524139485 2665 5343475 SGTC_2856 9022925 19.48 µM -0.0885090442528245 0.465935994619603 no 1816 0.464736048138999 2667 4944862 SGTC_93 0109-0045 59.227 µM -0.0887734039733319 0.465839456221316 no 1817 0.464630997387188 2534 88733 SGTC_345 1362-0200 395 µM -0.0908845769307637 0.465068574547097 no 1818 0.463792152647925 2584 1419823 SGTC_270 tamoxifen 5.46 µM -0.0922747065015647 0.464561048771757 no 1819 0.463239891952149 2575 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2054 5233173 129 µM -0.0934480901113703 0.464132700141292 no 1820 0.462773793623036 2656 6889 SGTC_1751 st044839 27.194 µM -0.0937727956733774 0.464014172330165 no 1821 0.462644821173305 2552 5291326 SGTC_3222 9128301 49.47 µM -0.0942587669309911 0.463836783404228 no 1822 0.462451801627976 2604 4911358 SGTC_586 0957-0265 8.15 µM -0.0948961951299766 0.463604120664239 no 1823 0.46219863936426 2564 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2457 5731572 11.68 µM -0.0960993554722353 0.463164998391999 no 1824 0.461720831598981 2643 2865357 SGTC_2380 9035439 200 µM -0.096210257780386 0.463124524181193 no 1825 0.461676792039905 2708 6462575 SGTC_1522 st012842 45.6 µM -0.096411200818082 0.463051190243167 no 1826 0.461596998299512 2568 3491067 YOR116C RPO31 SGTC_793 0488-0545 106 µM -0.0965526022140711 0.462999586713573 no 1827 0.461540849252248 2574 292548 SGTC_3168 9103419 49.47 µM -0.0974428266980027 0.462674719350992 no 1828 0.461187367870425 2569 16649256 SGTC_1842 st055362 61.2 µM -0.0974640889813014 0.462666960463422 no 1829 0.461178925630693 2585 676032 SGTC_962 1254-0300 21.5 µM -0.0975768418955322 0.462625815675555 no 1830 0.461134157112631 2566 7340576 SGTC_135 0933-0004 26.348 µM -0.0976719306305573 0.462591117053221 no 1831 0.461096402535586 2658 21230617 YGL099W LSG1 SGTC_88 0180-0332 8.668 µM -0.097818650318463 0.462537578451354 no 1832 0.461038148796753 2551 3101745 SGTC_1403 3909-7815 62.9 µM -0.0981086788335263 0.462431747882072 no 1833 0.460922998031784 2574 6615483 SGTC_1883 5-benzylidenerhodanine 20 µM -0.0993959320488376 0.461962065092526 no 1834 0.460411956262958 2642 1273210 SGTC_1709 st033179 39.1045 µM -0.0997350900663328 0.46183832459455 no 1835 0.460277320787627 2571 573381 SGTC_1642 st009582 77.7 µM -0.101330002334418 0.46125647671387 no 1836 0.459644250170841 2630 6739311 SGTC_912 3474-0017 2.18 µM -0.101477058858629 0.461202832448058 no 1837 0.459585883958932 2707 3360550 SGTC_3345 9148410 3.559 µM -0.10252882358761 0.460819183289532 no 1838 0.459168467741306 2619 4903596 SGTC_1710 st031758 61.5 µM -0.103107479017638 0.460608124360231 no 1839 0.458938834632749 2736 5394341 SGTC_260 nsc-65238 3.989 µM -0.104230249478938 0.460198636482886 no 1840 0.458493314545909 2598 3246252 SGTC_1030 k029-0042 36.7 µM -0.104287162406938 0.460177880774611 no 1841 0.458470732638044 2646 6080581 SGTC_1596 piperlongumine 63 µM -0.104329456342966 0.460162456570847 no 1842 0.458453951339668 2707 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_60 0986-0278 202 µM -0.104522824399716 0.460091937809086 no 1843 0.458377228115219 2589 3110598 SGTC_1653 st012112 65 µM -0.105162972736015 0.459858493182742 no 1844 0.45812324561746 2700 720429 SGTC_721 1187-1332 279 µM -0.105541912585636 0.45972031067706 no 1845 0.457972907123723 2568 25730 SGTC_3264 9137442 49.47 µM -0.105712571114262 0.459658080691563 no 1846 0.457905202968172 2681 17015726 SGTC_548 1436-0017 110 µM -0.107022892641865 0.459180309952322 no 1847 0.45738540917784 2638 9677137 SGTC_1923 st058458 19.1 µM -0.107869085100862 0.458871801699446 no 1848 0.457049770256358 2737 3534982 SGTC_1238 0333-0287 48.8 µM -0.108250172483268 0.458732871405745 no 1849 0.456898623430946 2613 7226 SGTC_231 b-estradiol 524 µM -0.1105841017217 0.457882118155147 no 1850 0.455973077571055 2601 450 A steroid. SGTC_1233 0325-0408 14.2 µM -0.111623106943229 0.457503446536667 no 1851 0.455561124913648 2679 12874 SGTC_2592 piperlongumine 83.33 µM -0.115055838135826 0.456252643405537 no 1852 0.454200431715397 2686 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1021 4476-0760 85.3 µM -0.116062351371451 0.455885976259621 no 1853 0.4538015631837 2615 746768 SGTC_2023 5144124 124 µM -0.116381342917277 0.455769777247477 no 1854 0.453675160551728 2636 2830192 SGTC_109 0132-0036 33.701 µM -0.117610773391074 0.455321968232868 no 1855 0.453188034132288 2595 67274 A color developer. SGTC_751 0833-0568 350 µM -0.118047701609568 0.455162834692703 no 1856 0.453014930834004 2672 6954252 SGTC_1491 4138-0063 26.5 µM -0.118078336541563 0.455151677419775 no 1857 0.453002794145718 2603 23883227 SGTC_3237 9133362 49.47 µM -0.118555521995307 0.454977890572058 no 1858 0.452813752523005 2623 43845137 SGTC_2019 4016004 108 µM -0.119911559743618 0.454484080403272 no 1859 0.452276603600731 2690 45595336 SGTC_465 cgp-37157 41 µM -0.120724366264509 0.454188125167428 no 1860 0.451954679330232 2619 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1640 st009078 66.4 µM -0.121581708676422 0.453875981300534 no 1861 0.451615150184151 2704 690618 SGTC_1138 3761-0006 1.03 µM -0.121827964273511 0.453786329062113 no 1862 0.451517633309168 2604 12061087 SGTC_278 4092-0821 23.9 µM -0.121924206445654 0.453751291610289 no 1863 0.451479522337239 2697 877900 SGTC_161 4065-0411 162.148 µM -0.122568357175139 0.453516794544108 no 1864 0.451224456391167 2736 1906281 YLR208W SEC13 SGTC_2783 7738165 71.43 µM -0.123973036414484 0.453005490477919 no 1865 0.450668312081802 2686 17201110 SGTC_1948 st076329 66.6 µM -0.125254634196363 0.45253905607604 no 1866 0.450160982963751 2607 24208413 SGTC_1940 st075990 51.1 µM -0.126391019798983 0.452125526051192 no 1867 0.449711205154973 2888 1084979 SGTC_3293 9120939 62.045 µM -0.127167288804461 0.451843072062316 no 1868 0.44940399745015 2750 934087 SGTC_2046 4110841 106 µM -0.127226248003873 0.451821620105332 no 1869 0.449380665641049 2676 44119630 YMR134W ERG29 SGTC_2406 ethylparaben 405.7 µM -0.12867977297828 0.451292808252539 no 1870 0.448805520576089 2634 8434 A possible steroid mimic. SGTC_474 dl-dihydrosphingosine 5 µM -0.128828982421344 0.451238528734354 no 1871 0.448746485982856 2795 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2960 9079389 5.97 µM -0.128865917088208 0.451225092755496 no 1872 0.448731872987502 2708 16457355 SGTC_1783 st039459 87.517 µM -0.128937708767381 0.451198976760413 no 1873 0.448703469208258 2864 729761 SGTC_2394 5221648 200 µM -0.130105054087158 0.450774355812997 no 1874 0.448241655764013 2742 788586 SGTC_815 1582-0027 36.9 µM -0.131412479085828 0.450298847890545 no 1875 0.447724508694515 2707 3128206 SGTC_642 0335-0876 158 µM -0.131939706249357 0.450107116544986 no 1876 0.447515991049771 2634 6812350 SGTC_1306 1185-0270 9.02 µM -0.131941624959616 0.450106418808361 no 1877 0.447515232228859 2715 1548076 SGTC_1831 st055328 12 µM -0.133112730150235 0.449680576702254 no 1878 0.447052113769293 2682 1103068 SGTC_1525 8-methoxypsoralen 92.5 µM -0.134163976978469 0.449298367323876 no 1879 0.446636455268762 2744 4114 Related to psoralen; DNA damaging agent. SGTC_2060 5238662 140 µM -0.134775529471936 0.449076042399541 no 1880 0.446394676969033 2739 790130 SGTC_92 0063-0024 660.874 µM -0.135399949845646 0.448849055958691 no 1881 0.446147831892454 2592 3594437 SGTC_2417 cerulenin 830 nM -0.135801750741164 0.44870300398089 no 1882 0.445989003496917 2625 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3323 9138564 53.9225 µM -0.136757367469937 0.448355671560219 no 1883 0.445611291386921 2739 43912313 YNL103W MET4 SGTC_847 0342-0274 5.54 µM -0.136834759909601 0.448327543912216 no 1884 0.445580703808822 2761 18097 SGTC_2771 fluoxetine 41.05 µM -0.138472094474986 0.4477325291839 no 1885 0.444933661258546 2801 3386 A selective serotonin reuptake inhibitor. SGTC_1039 k821-0043 94 µM -0.140468448809088 0.447007204287127 no 1886 0.444144939751636 2654 15992768 SGTC_2402 5553605 200 µM -0.14212289326505 0.446406237885602 no 1887 0.443491467757475 2814 6758546 SGTC_1862 st057513 3.81 µM -0.142407140389705 0.446302999280631 no 1888 0.443379211326892 2681 5393163 SGTC_421 streptovitacin 30 mM -0.14317772571265 0.446023140886185 no 1889 0.443074910434705 2859 91467 include heat shock SGTC_880 0833-0487 87.2 µM -0.143205900339833 0.44601290903552 no 1890 0.443063785028427 2663 76075 SGTC_527 4476-4215 268 µM -0.143733592016291 0.445821280055089 no 1891 0.442855422010194 2678 4418754 SGTC_2670 beta-carotene 100 µM -0.143952500098052 0.445741788230758 no 1892 0.442768989145869 2678 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3046 9092212 49.47 µM -0.144535237041327 0.445530190315706 no 1893 0.442538916714479 2643 25236637 SGTC_503 tyrphostin 8 294 µM -0.145743184130364 0.445091621500457 no 1894 0.442062064657774 2690 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3057 9095946 49.47 µM -0.145842891037065 0.445055423952896 no 1895 0.44202270786396 2648 24540043 SGTC_86 0417-1630 471.922 µM -0.147784538901312 0.444350620734999 no 1896 0.441256405758364 2659 3634867 SGTC_3088 9117578 49.47 µM -0.147993763855158 0.444274684149525 no 1897 0.441173844885696 2675 678341 SGTC_403 arphamenine a 50 µM -0.148042816972505 0.444256880994316 no 1898 0.441154488729897 2667 5487158 An arginine aminopeptidase inhibitor. SGTC_2838 9002687 71.43 µM -0.148965297336161 0.443922100401568 no 1899 0.440790508048078 2643 6457060 SGTC_2415 st077333 57.7 µM -0.149151307575487 0.443854599611441 no 1900 0.440717120520369 2717 2766255 SGTC_3129 9127257 49.47 µM -0.151447098717764 0.443021620424005 no 1901 0.439811519246318 2700 837894 SGTC_3304 9125678 46.087 µM -0.151800203345118 0.442893526136512 no 1902 0.439672260873671 2704 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2652 actinonin 100 µM -0.156610514023585 0.441149109895433 no 1903 0.437775907904995 2658 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2537 larixol 68.93 µM -0.157951040379792 0.440663181843469 no 1904 0.437247689210912 2660 6708759 SGTC_1145 3546-0597 10.2 µM -0.158982798378558 0.44028924018521 no 1905 0.436841213180079 2728 875334 SGTC_1098 clofazimine 15.1 µM -0.160018988436885 0.439913745801697 no 1906 0.436433058175404 2772 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_216 k038-0035 28.382 µM -0.160740518983683 0.439652309576685 no 1907 0.436148887414521 2671 4444231 YPR107C YTH1 SGTC_2832 7992762 51.95 µM -0.161049151403505 0.439540489083417 no 1908 0.43602734432115 2684 2985177 SGTC_1649 st011737 51.3 µM -0.161097724147198 0.439522891150418 no 1909 0.43600821635071 2737 1761035 SGTC_2211 7117706 200 µM -0.162631118041386 0.438967403276148 no 1910 0.435404442254413 2735 822771 SGTC_171 k064-0041 9.68 µM -0.164258684309158 0.43837793198029 no 1911 0.434763752503196 2723 53325 SGTC_347 4534-1311 26.2 µM -0.164610891450816 0.438250387684284 no 1912 0.434625129015656 2676 2862016 SGTC_3145 9085516 49.47 µM -0.16494733910508 0.438128556339545 no 1913 0.434492715732903 2766 25236195 SGTC_2909 7941780 10.49 µM -0.165137222571051 0.438059800064908 no 1914 0.434417987906232 2713 1243215 SGTC_3135 9127742 49.47 µM -0.16530746202783 0.43799815842094 no 1915 0.434350992887479 2772 3643468 SGTC_1428 4049-0204 61.7 µM -0.165653759919804 0.437872772795713 no 1916 0.434214718704202 2799 X1428 SGTC_96 0929-0093 37.281 µM -0.166520628507204 0.437558929189655 no 1917 0.433873625300142 2687 6991579 SGTC_1454 4239-0054 42.6 µM -0.166588158131331 0.437534482216222 no 1918 0.433847055967003 2890 1340767 SGTC_560 2332-1943 155 µM -0.166590906435153 0.437533487284437 no 1919 0.43384597466123 2686 21177716 SGTC_1641 st009299 47.1 µM -0.168020679346384 0.437015939359605 no 1920 0.433283505292422 2705 4046054 SGTC_3343 9148379 18.9835 µM -0.168414409162635 0.436873436279523 no 1921 0.433128636568142 2846 1955036 SGTC_2141 5621638 7.665 µM -0.168498930565273 0.436842846419413 no 1922 0.43309539246409 2827 2856238 SGTC_3053 9095903 49.47 µM -0.169059534433437 0.436639963070067 no 1923 0.432874906777763 2708 17174018 SGTC_1042 0350-0096 82 µM -0.169622773316425 0.436436142888167 no 1924 0.432653405782532 2660 3122515 SGTC_1718 roemerine 11.9335 µM -0.170066206197839 0.436275688971608 no 1925 0.432479034935608 2805 235224 An aporphine alkaloid with mutagenic activity. SGTC_2471 5466956 24.79 µM -0.17032348451143 0.436182598936994 no 1926 0.432377871563805 2748 724419 SGTC_1278 0874-0585 172 µM -0.170547659125052 0.436101489570099 no 1927 0.432289728378671 2755 766306 SGTC_1122 capsaicin 818.572 nM -0.17064396762525 0.436066644694451 no 1928 0.432251861887484 2842 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2757 clomiphene 4.22 µM -0.172958397959887 0.435229422600579 no 1929 0.431342064168951 2870 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1937 st074714 47.2 µM -0.173526786327643 0.435023858029366 no 1930 0.431118687401263 2694 17250970 SGTC_1405 3909-7894 12 µM -0.174556777179508 0.434651394082779 no 1931 0.430713956925942 2822 7104060 SGTC_3024 9090631 49.47 µM -0.174848996943601 0.434545732499298 no 1932 0.430599143658194 2731 25236383 SGTC_2558 carylophyllene oxide 100 µM -0.174960459465225 0.43450543082171 no 1933 0.430555351531745 2705 6708694 An oxygenated terpenoid and antifungal agent. SGTC_625 k213-0058 121 µM -0.175450684975727 0.43432818730501 no 1934 0.430362758663167 2769 3655420 SGTC_936 3005-4620 401 µM -0.175962204901578 0.434143258757863 no 1935 0.430161817605586 2913 777207 SGTC_51 1013-0126 23.419 µM -0.176097008564285 0.434094525917353 no 1936 0.430108865511249 2874 1627850 SGTC_3012 9080433 71.4286 µM -0.176791432906786 0.433843500621812 no 1937 0.429836109303586 2753 17688859 SGTC_2505 galangin 7.89 µM -0.17860817322209 0.433186899269957 no 1938 0.429122688194205 2691 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_190 3970-0790 3.722 µM -0.179034386608085 0.433032885021902 no 1939 0.428955350638945 2693 2832352 SGTC_1213 1315-0166 115 µM -0.179458630073605 0.432879592714669 no 1940 0.42878879918311 2846 768401 SGTC_36 0335-0881 14.2 µM -0.181412430688747 0.432173754737746 no 1941 0.428021931242006 2713 23828853 SGTC_3260 9137109 49.47 µM -0.182515712831244 0.431775274001012 no 1942 0.427589012201043 2834 17478346 SGTC_1439 4092-1168 46 µM -0.186768542023558 0.430239900554797 no 1943 0.425921056350575 2745 2886240 SGTC_748 act1.228 77.9 µM -0.18713246730205 0.430108563427785 no 1944 0.425778386277465 2737 4421505 YNR035C ARC35 SGTC_918 glabranin 770.725 nM -0.187439135494428 0.429997895834414 no 1945 0.425658170312436 2788 124049 Also referred to as licorice root. SGTC_1070 indatraline 8.81 µM -0.187734265236285 0.429891397323606 no 1946 0.425542484021313 2754 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1149 3909-7961 23.3 µM -0.187901717861348 0.429830973776215 no 1947 0.425476848033351 2742 735261 SGTC_514 4466-0038 2.65 nM -0.188279213734185 0.429694764326696 no 1948 0.425328889495456 2794 5722064 SGTC_268 camptothecin 39.6153 µM -0.18859829911039 0.429579637293016 no 1949 0.425203833001829 2740 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1478 0453-0656 35.7 µM -0.188887418646358 0.429475327202325 no 1950 0.425090527270531 2754 5258496 SGTC_2770 toltrazuril 17.5 µM -0.189303816521768 0.429325105606368 no 1951 0.424927352128004 2725 68591 Kills coccidiodes. SGTC_2490 carminic acid 95.39 µM -0.18955973806775 0.429232783259309 no 1952 0.42482706972845 2701 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2178 5812956 200 µM -0.189865147225058 0.429122613584079 no 1953 0.424707402064387 2674 5403383 SGTC_945 3381-0768 11.3 µM -0.190270356552218 0.428976451703311 no 1954 0.424548640675565 2843 1126236 YIL048W NEO1 SGTC_1555 citronellol 128 µM -0.190335976757148 0.428952782945288 no 1955 0.424522931769547 2777 8842 A terpine precursor. SGTC_1003 4049-0218 100 µM -0.192760238776889 0.428078548016253 no 1956 0.423573372141775 2906 295161 SGTC_2297 7971671 152.32 µM -0.193434350529429 0.42783551304069 no 1957 0.423309407788623 2900 909016 SGTC_768 0384-0033 77.3 µM -0.193630325373362 0.427764864099161 no 1958 0.423232675669322 2763 3965305 YMR134W ERG29 SGTC_878 0828-0289 13.7 µM -0.194396485082683 0.427488685729342 no 1959 0.422932720961789 2774 745350 YLR208W SEC13 SGTC_2043 5101342 149 µM -0.195900630315122 0.42694658843373 no 1960 0.42234397195385 2773 678451 SGTC_3133 9127736 49.47 µM -0.19640326556147 0.42676546826901 no 1961 0.422147270244791 2733 27243420 SGTC_2889 9059656 51.95 µM -0.197192419068571 0.426481134948852 no 1962 0.421838481426448 2845 3949838 SGTC_1852 st056254 31.4 µM -0.200009966899591 0.425466280496458 no 1963 0.420736393081515 2781 442583 SGTC_988 1497-1057 103 µM -0.202181490986841 0.424684454220744 no 1964 0.419887421191261 2766 3533044 SGTC_1015 4130-4525 82 µM -0.202451552743152 0.424587242983799 no 1965 0.419781864714303 2777 1363237 SGTC_2119 5528445 120.635 µM -0.202665557772246 0.424510213143497 no 1966 0.419698222696761 2894 791935 SGTC_1619 st003326 88.7 µM -0.202686310355431 0.424502743527626 no 1967 0.419690111921722 2930 2849032 SGTC_1411 3909-8223 150 µM -0.202807028747641 0.424459293088132 no 1968 0.419642931979175 2850 X1411 SGTC_2708 st078559 56 µM -0.206605161535784 0.423092694178268 no 1969 0.418159114458556 2811 17250902 SGTC_107 0358-0022 2.6945 µM -0.206918602474094 0.42297995668025 no 1970 0.418036714115511 2843 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3076 9116187 49.47 µM -0.208005473114986 0.422589083211851 no 1971 0.41761234694633 2890 27241210 SGTC_2379 9035213 200 µM -0.210651397453873 0.421637843471909 no 1972 0.416579651355921 2907 646551 SGTC_2705 st078069 42.8 µM -0.210975751383571 0.421521265903686 no 1973 0.416453096535638 2859 1530061 SGTC_764 1951-2361 146 µM -0.211662838018483 0.421274339601299 no 1974 0.416185041071121 2795 5438930 SGTC_444 curcumin 90.4 µM -0.212529738799349 0.420962835586004 no 1975 0.415846889730109 2914 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2131 toluylene red 5.2905 µM -0.212874512791526 0.42083896146584 no 1976 0.415712421297174 2820 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1545 lovastatin 49.4 µM -0.213752769280836 0.420523447435664 no 1977 0.41536992913906 2829 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_136 0097-0015 404.482 µM -0.21449504207926 0.420256825406426 no 1978 0.4150805164238 2765 4861337 SGTC_2919 7978188 46.38 µM -0.216113440596162 0.419675628815773 no 1979 0.414449661592964 2934 2980291 SGTC_463 ikarugamyin 104 µM -0.21756794231985 0.419153439983771 no 1980 0.413882882226803 2779 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.21798617990456 0.419003312475765 no 1981 0.413719939675741 2952 688751 SGTC_2551 apiole 73.87 µM -0.219625136420338 0.418415118473465 no 1982 0.41308155665471 2774 10659 A possible DNA adduct former. SGTC_2213 7173844 200 µM -0.220100708618867 0.418244477669539 no 1983 0.412896361471551 2817 892728 SGTC_622 1348-1566 26.3 µM -0.220566587022408 0.418077330030654 no 1984 0.412714959997525 2880 7340407 SGTC_2223 6903751 107.57 µM -0.221387622689382 0.417782795263473 no 1985 0.412395314503194 2892 5598863 SGTC_2358 9037157 4 µM -0.221690951823296 0.417673991944515 no 1986 0.412277237131518 2895 2388925 SGTC_925 2064-1272 59.6 µM -0.222340048378436 0.417441183992739 no 1987 0.412024589062232 2824 6815817 SGTC_2081 5214970 32.255 µM -0.222837752268974 0.417262694825672 no 1988 0.411830892300837 2883 2063512 SGTC_2238 6671620 73.2395 µM -0.223225489922853 0.417123654137054 no 1989 0.411680007163121 2738 729941 SGTC_1270 0831-1170 17.3 µM -0.223821839501122 0.416909826540925 no 1990 0.41144796778879 2777 6764716 SGTC_567 1080-0542 68.4 µM -0.224775850020697 0.416567806877374 no 1991 0.411076827123269 2802 5950415 SGTC_1279 0874-0590 65.2 µM -0.224805755933807 0.416557086410994 no 1992 0.411065194049386 2873 3523074 SGTC_3269 9137823 49.47 µM -0.226160268769979 0.416071595134799 no 1993 0.410538385479279 2797 17682936 SGTC_2681 menadione 3.18 µM -0.226483319827777 0.415955824439283 no 1994 0.410412765530436 2871 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3267 9137951 49.47 µM -0.226620227252269 0.415906763596503 no 1995 0.410359531195762 2764 16643986 SGTC_612 0302-0167 22.4 µM -0.227571129902695 0.415566043367502 no 1996 0.409989833031935 2877 235821 SGTC_2945 9067681 61.76 µM -0.227876757593724 0.415456546636471 no 1997 0.409871026067189 2751 16456930 SGTC_215 1287-0124 461.5 µM -0.22882853703884 0.41511559627029 no 1998 0.409501092923011 2877 5560863 SGTC_113 0099-0221 2.5 µM -0.229472716900335 0.414884871751848 no 1999 0.409250761828263 2983 89219 SGTC_680 0417-1641 114 µM -0.231741812919029 0.414072388836927 no 2000 0.40836927663026 2801 2835990 SGTC_1417 3966-0327 90.4 µM -0.232025026944528 0.413971005660902 no 2001 0.408259287737139 2860 651118 SGTC_394 menadione 8.33 µM -0.232372067538197 0.41384678206891 no 2002 0.408124521036896 2896 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1273 0849-0096 14.1 µM -0.23305241503693 0.413603275901777 no 2003 0.407860352406662 2847 5286025 SGTC_1904 st060225 78 µM -0.233192616231657 0.413553100000689 no 2004 0.407805919606924 2822 66595 SGTC_781 4335-2806 94.4 µM -0.234423419446333 0.413112674701249 no 2005 0.407328139515033 2996 845254 SGTC_2511 berberine 10.47 µM -0.234468557830768 0.4130965246519 no 2006 0.407310620059878 2838 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_608 k048-0125 159 µM -0.235535941805604 0.412714668566849 no 2007 0.406896392931047 2930 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_796 1234-0020 70.7 µM -0.235783420090181 0.412626145114716 no 2008 0.406800367164128 2807 46495034 SGTC_1613 st002381 52.1 µM -0.236006901043799 0.412546209371676 no 2009 0.406713657582437 2823 551167 SGTC_3356 9151811 4.48 µM -0.23810213042479 0.411796954485607 no 2010 0.405900941205733 2822 1859254 YPR165W RHO1 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.239315985285432 0.41136302638026 no 2011 0.405430285513861 2916 140250 A respiratory chain inhibitor. SGTC_1813 st051246 8.6015 µM -0.242827866200042 0.410108213627432 no 2012 0.404069373718135 2915 5291959 SGTC_249 wiskostatin 11.211 µM -0.242895223267155 0.410084155557962 no 2013 0.404043283031149 2846 2775510 A n-wasp and actin depolymerizer. SGTC_2179 6298986 200 µM -0.244431447504791 0.409535551075853 no 2014 0.403448344343129 2983 738374 SGTC_1688 st021091 57.6 µM -0.244499805995485 0.409511143529466 no 2015 0.403421876103107 2937 3656366 SGTC_140 0062-0056 502.533 µM -0.245513174114349 0.409149359445339 no 2016 0.403029554401944 2800 3758964 SGTC_192 3455-0609 60.9 µM -0.247065213315769 0.408595413680293 no 2017 0.402428877524688 2974 3769639 SGTC_875 0709-0210 25.7 µM -0.247869570127188 0.408308398582578 no 2018 0.402117662412378 2829 6251364 SGTC_318 1488-0629 67.2 µM -0.249562211877741 0.407704581502328 no 2019 0.401462962284325 2922 3662576 SGTC_2362 9071156 126 µM -0.249917713112401 0.407577791142725 no 2020 0.401325492360181 3021 653133 SGTC_1136 pergolide 1.05886 µM -0.25046262974572 0.407383464127497 no 2021 0.401114800495146 2855 47811 A dopamine receptor agonist. SGTC_2862 9027634 71.43 µM -0.251905140543946 0.40686914912734 no 2022 0.400557193057735 2817 5012562 SGTC_1579 chlormadinone acetate 49.4 µM -0.252125940978791 0.406790438751911 no 2023 0.400471859752007 3009 45114258 A steroidal progestin. SGTC_617 3770-0098 35 µM -0.252238796573595 0.40675020973133 no 2024 0.400428245997449 2869 5962639 SGTC_1969 st069479 40.1 µM -0.252922073882804 0.406506666610418 no 2025 0.400164215714678 3032 3895485 SGTC_2263 7948595 193.29 µM -0.253142117666908 0.406428243263811 no 2026 0.400079196661248 2849 2971371 SGTC_1564 D-Arginine 115 µM -0.255402135493614 0.405622993338177 no 2027 0.399206260793946 2892 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3083 9117465 49.47 µM -0.256186569389396 0.405343590765681 no 2028 0.398903389369642 2965 16420915 SGTC_1887 st057648 70.8 µM -0.259211882025006 0.404266476602859 no 2029 0.397735881907545 3007 688672 SGTC_2476 5806916 10.51 µM -0.26096898483216 0.403641220672568 no 2030 0.397058212594935 2858 2870194 SGTC_2002 4023503 131 µM -0.263552784416189 0.402722236551399 no 2031 0.39606227248669 2964 4736863 YCR052W RSC6 SGTC_1546 5-methoxyflavanone 78.7 µM -0.264316012649791 0.402450880499782 no 2032 0.39576821129696 2940 147795 SGTC_2586 curcumin 80 µM -0.264454717071078 0.402401570956834 no 2033 0.395714776783381 2985 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_736 0958-0254 92.6 µM -0.266310624661047 0.401741943882086 no 2034 0.394999995588576 2991 6812352 SGTC_3084 9116877 49.47 µM -0.26844774755646 0.400982713940564 no 2035 0.394177345258916 2966 27241325 SGTC_2951 9072950 58.06 µM -0.269846831128759 0.400485880625882 no 2036 0.393639046365688 2876 16488155 SGTC_2747 doxorubicin 7.63 µM -0.270732005278506 0.400171626516019 no 2037 0.393298579552207 2900 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_134 0269-0018 6.916 µM -0.272143204614807 0.399670756915475 no 2038 0.392755955124912 2957 4378915 SGTC_2243 6634756 200 µM -0.27292354671466 0.399393864989157 no 2039 0.392455992874143 3144 885676 SGTC_2942 9052777 62.25 µM -0.272980272277073 0.399373738800837 no 2040 0.392434190147451 2917 6469503 SGTC_650 1328-0195 38 µM -0.273665128286336 0.399130773506122 no 2041 0.392170989302387 2957 2780821 SGTC_3096 9117468 49.47 µM -0.275583341824449 0.398450460150531 no 2042 0.391434052843345 3027 41316311 SGTC_1774 st048371 48.465 µM -0.275830701013733 0.398362754186942 no 2043 0.391339051049734 2884 4242727 SGTC_2619 obliquin 87.91 µM -0.275836590339128 0.398360666075777 no 2044 0.391336789250034 2885 6708593 A bioactive alkalod. YER133W GLC7 SGTC_62 0180-0423 3.232 µM -0.275900253633933 0.398338093890739 no 2045 0.391312339549927 2919 30102 YGL099W LSG1 SGTC_3227 9130768 49.47 µM -0.278095743618481 0.397559878996403 no 2046 0.390469431511217 2890 17720899 SGTC_558 k064-0027 21.3 µM -0.278542489184226 0.397401575054505 no 2047 0.390297976668827 2999 5088526 SGTC_1874 staurosporine 7.6 µM -0.278778404964896 0.397317985298116 no 2048 0.390207444022184 3022 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3113 9123498 49.47 µM -0.279459377444784 0.397076729371373 no 2049 0.389946154345226 2889 8897275 SGTC_1588 farnesol 29.9 µM -0.279535484442466 0.397049768517732 no 2050 0.389916955117125 2901 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1215 3852-0577 11.2 µM -0.279854591930854 0.396936730258441 no 2051 0.389794533029786 3058 2884876 SGTC_2815 7968870 71.43 µM -0.280047880435872 0.396868265388556 no 2052 0.389720385330858 2897 2977326 YHR190W ERG9 SGTC_2412 st077135 33.4 µM -0.280775064502459 0.396610717453637 no 2053 0.389441465113528 3168 13258915 SGTC_2684 capsaicin 100 µM -0.280938068223465 0.396552992350953 no 2054 0.389378950878632 2987 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2791 5663188 71.43 µM -0.282483398067787 0.396005851856903 no 2055 0.388786437433699 3068 54690634 SGTC_2318 6029776 164 µM -0.282642070083019 0.395949683916138 no 2056 0.388725613710873 3098 818325 SGTC_1115 galangin 695.678 nM -0.283112449786773 0.395783187988427 no 2057 0.388545319154971 3043 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2777 climbazole 1.536 µM -0.284632532025668 0.395245268774074 no 2058 0.387962842387984 2981 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1406 3909-7906 11.9 µM -0.28643103731669 0.39460908037314 no 2059 0.387274002853239 2955 X1406 SGTC_177 1327-0068 8.361 µM -0.288741577195492 0.393792181628164 no 2060 0.386389571578813 2975 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2438 5259590 200 µM -0.289601125736818 0.393488404524855 no 2061 0.386060702839404 3009 1201127 SGTC_1587 estradiol valerate 56.1 µM -0.289698562450119 0.393453973043692 no 2062 0.386023428094267 3065 13791 A steroid. SGTC_2946 9065502 71.43 µM -0.291069986646431 0.392969437591424 no 2063 0.385498896889809 2949 16489101 SGTC_1499 4480-0877 67.3 µM -0.29457779739072 0.391730855158501 no 2064 0.384158212522449 2929 2861909 SGTC_3201 9113999 49.47 µM -0.295002730201457 0.391580888696938 no 2065 0.38399589703835 3118 16649224 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.296500882221398 0.391052292472055 no 2066 0.383423796663277 2933 165521 SGTC_3181 9108277 49.47 µM -0.299096031843608 0.390137116834988 no 2067 0.382433386956862 2946 17097298 SGTC_1744 st037937 38.9 µM -0.300144142191029 0.389767674519269 no 2068 0.382033604924481 3125 1016152 SGTC_2571 chrysanthemic acid 100 µM -0.30045712586166 0.389657372018475 no 2069 0.381914247537255 2981 2743 An insecticide. SGTC_360 0957-0399 1.01 µM -0.300956476972654 0.3894814078346 no 2070 0.381723841535305 3071 6752301 YPR165W RHO1 SGTC_1276 0871-0068 94.2 µM -0.302300002006686 0.38900808142179 no 2071 0.381211688405321 3017 3414906 SGTC_2828 7998861 71.43 µM -0.302540285725055 0.388923446352844 no 2072 0.381120113902641 3057 2988188 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.308988227847484 0.386654270179192 no 2073 0.378665240886866 3024 6708739 YPR165W RHO1 SGTC_2651 TUB2.036 5 µM -0.310271690100083 0.38620305023822 no 2074 0.378177178793076 3090 15992207 YFL037W TUB2 SGTC_1845 st056753 3.01 µM -0.312640227341551 0.385370760689422 no 2075 0.377277006038439 2902 5375839 SGTC_1024 4507-0395 26 µM -0.313054806910131 0.385225134110394 no 2076 0.377119511686833 3122 4201836 SGTC_1239 0337-0584 35.4 µM -0.313935882192841 0.384915698485047 no 2077 0.376784868501486 3130 914301 YML130C ERO1 SGTC_709 3807-1509 243 µM -0.314714081483224 0.384642454079199 no 2078 0.376489375841974 2976 1886677 YPL242C IQG1 SGTC_3305 9127027 53.8275 µM -0.31515997677592 0.384485915375624 no 2079 0.376320096045241 2984 41905295 SGTC_2089 5281248 129.67 µM -0.315515860232646 0.384360990286462 no 2080 0.376185005431101 2974 2737878 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.315837647460276 0.384248044270124 no 2081 0.376062870539863 2961 16623 A steroid. SGTC_2879 9041815 71.43 µM -0.316028049778594 0.384181218453385 no 2082 0.375990608859392 3068 4942971 SGTC_1540 guanosine 70.6 µM -0.316299714686823 0.384085877731738 no 2083 0.375887513846779 2941 6802 Guanosine is a purine nucleoside SGTC_2839 9003951 25.97 µM -0.316442456055672 0.384035785499793 no 2084 0.375833348003201 3075 2990634 SGTC_337 1315-0038 354 µM -0.316794085484001 0.383912396441613 no 2085 0.375699926173891 2976 1626437 SGTC_157 1348-1695 65.819 µM -0.31700060153397 0.383839934097928 no 2086 0.375621572909258 2948 5380510 SGTC_2866 9034245 58.44 µM -0.317200978689233 0.383769629651383 no 2087 0.375545553676053 3029 6462273 SGTC_2748 diazoxide 86.69 µM -0.318797860474271 0.383209483678304 no 2088 0.374939900395401 3036 3019 A potassium channel activatior. SGTC_2614 arthonioic acid 13.39 µM -0.320506500151284 0.38261040616426 no 2089 0.374292201823194 2929 6710684 SGTC_3117 9124945 49.47 µM -0.321137154111937 0.382389359257213 no 2090 0.374053227659752 2908 17592065 SGTC_2474 5321570 43.32 µM -0.323326102135639 0.381622421368996 no 2091 0.373224144030498 3092 2841384 SGTC_1140 3229-1848 2.98 µM -0.325075942738837 0.38100966668324 no 2092 0.372561797962923 3092 2849525 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.325922104464394 0.380713466834247 no 2093 0.372241645560741 3026 688761 SGTC_350 k064-0020 19.8 µM -0.327564196672948 0.380138850236945 no 2094 0.371620598247456 3169 2790705 SGTC_3005 9076496 71.4286 µM -0.328041215358677 0.379971976814355 no 2095 0.371440249977455 3087 21368410 SGTC_1556 plumbagin 1.48 µM -0.328729864052567 0.379731109184678 no 2096 0.371179939729617 3012 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1985 st071382 65.5 µM -0.328944794119398 0.379655942963804 no 2097 0.37109870789882 3005 6123237 SGTC_1456 k015-0012 13 µM -0.329258569252626 0.379546216408514 no 2098 0.370980128342361 3189 2989616 SGTC_2106 5357045 167.29 µM -0.330650599741561 0.379059543134001 no 2099 0.370454210438337 3073 668842 SGTC_2102 5377816 72.7585 µM -0.331861182020832 0.378636462451203 no 2100 0.369997041529957 3177 1379702 SGTC_2851 9015922 71.43 µM -0.332945209614876 0.378257734151544 no 2101 0.369587821034946 3166 2996893 SGTC_1210 3013-0140 750 nM -0.333109187529148 0.378200455122187 no 2102 0.369525932208231 3114 905973 SGTC_1815 st051655 58.2 µM -0.333186365066929 0.378173497207924 no 2103 0.369496804898889 3090 5984156 SGTC_1961 st076550 68.7 µM -0.333463147349138 0.378076822751216 no 2104 0.369392351609525 3097 1579337 SGTC_1144 3486-0183 12.5 µM -0.333641882775095 0.37801439813566 no 2105 0.369324904787158 3011 6744069 SGTC_34 0469-0683 81.75 µM -0.333794854223783 0.377960974301167 no 2106 0.369267183341174 3062 3690923 SGTC_594 1487-1584 10.8 µM -0.334230407973746 0.37780887405108 no 2107 0.369102849914914 3001 5013332 SGTC_1821 st053465 65.6 µM -0.334824841250306 0.377601321860988 no 2108 0.368878610216218 3065 675086 SGTC_1638 st008370 60.6 µM -0.335483665676591 0.377371328160588 no 2109 0.368630132209247 2988 24207134 SGTC_1946 st076057 65.1 µM -0.33603975699588 0.377177232129237 no 2110 0.368420443096977 2966 953009 SGTC_1118 chelidonine 707.474 nM -0.337391143363262 0.376705678696232 no 2111 0.367911030120926 3111 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2233 sulbentine 40.3845 µM -0.338472859603516 0.376328356563587 no 2112 0.367503438161324 3058 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2208 7283366 200 µM -0.339248460157457 0.376057885813231 no 2113 0.367211282774093 3084 898663 SGTC_130 0136-0219 337.655 µM -0.339522875457903 0.375962205104053 no 2114 0.367107933650902 2951 234244 SGTC_379 3970-0972 5.9 µM -0.340713354783219 0.375547207622371 no 2115 0.366659691972424 3050 2898042 YBL034C STU1 SGTC_2649 anisomycin 9.56 µM -0.342370116679942 0.374969905109362 no 2116 0.366036187275128 3062 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1208 2323-2347 50.3 µM -0.342414552601094 0.374954425160133 no 2117 0.366019469151325 3164 5412760 SGTC_2429 5902844 64.44 µM -0.342870576733814 0.374795573655455 no 2118 0.365847913926343 3146 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_666 0272-0154 136 µM -0.342956964412038 0.374765483752833 no 2119 0.365815418102238 3053 6870312 SGTC_633 0437-0093 97.7 µM -0.344384737275742 0.374268283267892 no 2120 0.36527848278443 3024 2831118 SGTC_269 exalamide 29 µM -0.346383916261383 0.373572450595783 no 2121 0.364527105409882 3029 3316 A derivative of salicylamide. SGTC_1782 st039423 80.636 µM -0.347316624142763 0.373247953814595 no 2122 0.364176731486856 3042 2068169 SGTC_692 k241-0027 77.8 µM -0.347837049255935 0.373066932666873 no 2123 0.363981281870164 3197 3600480 SGTC_570 0987-0065 62.6 µM -0.352336560086427 0.371503025519461 no 2124 0.362292936416724 2976 3104428 SGTC_2756 carbadox 75.1 µM -0.352739343941676 0.371363131789747 no 2125 0.362141930346554 3037 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2642 cholecalciferol 100 µM -0.352794224397186 0.371344072182744 no 2126 0.36212135699657 3122 9821465 A vitamin D precursor, similar to steriods. SGTC_864 0469-0573 172 µM -0.354980640980952 0.370585001758924 no 2127 0.361302047134228 3028 689425 SGTC_513 4245-1575 41.7 µM -0.355184484533695 0.370514257872983 no 2128 0.361225693742553 3111 719745 SGTC_1254 0550-0035 264 µM -0.355391141695321 0.370442541993859 no 2129 0.361148292104306 3166 15121435 SGTC_396 dithiazanine 1.25 µM -0.356102371055865 0.370195759719764 no 2130 0.360881950812706 3034 10578 An antihelmenthic. SGTC_1931 st074438 57.1 µM -0.358696065270507 0.369296253376285 no 2131 0.359911236118966 3053 2787313 SGTC_1787 fluconazole 80 µM -0.358806803114475 0.369257864812135 no 2132 0.359869811481468 3136 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2160 5660466 132.927 µM -0.359775953447067 0.368921953227297 no 2133 0.359507343542083 3127 2859134 SGTC_1265 0819-1001 68.8 µM -0.360116935861957 0.368803791078334 no 2134 0.359379844143475 3090 3106768 SGTC_1720 st037298 9.481 µM -0.360574862997761 0.368645123067889 no 2135 0.359208641662564 3136 597396 SGTC_3306 9127676 59.7925 µM -0.360691617904451 0.368604672027965 no 2136 0.359164995724447 3103 41905287 SGTC_2158 5657123 3.6195 µM -0.360737195599436 0.368588881522167 no 2137 0.359147958127676 3045 2858827 SGTC_1340 1486-1359 257 µM -0.360920358679179 0.368525426455486 no 2138 0.359079491963848 3052 4309068 SGTC_1318 1280-3875 124 µM -0.362606337040341 0.367941504245228 no 2139 0.358449487876016 3099 373245 SGTC_2038 4100038 30.985 µM -0.363711185957931 0.367559015918107 no 2140 0.35803684473337 3140 3596803 SGTC_1012 4112-3522 18 µM -0.364461121274339 0.367299470153183 no 2141 0.357756850490757 3210 3112398 SGTC_372 0155-0182 15.9 µM -0.364809629920781 0.367178875116742 no 2142 0.357626758083345 3015 771486 SGTC_2693 st077581 40.7 µM -0.366282735589376 0.366669278733151 no 2143 0.357077055412558 3187 25238761 SGTC_674 0498-0004 451 µM -0.37050833723313 0.365208808411805 no 2144 0.355501882834392 3116 4231473 SGTC_2430 5571206 200 µM -0.371228724021504 0.364960019536542 no 2145 0.355233590284697 3213 1731771 SGTC_532 1548-0774 215 µM -0.371481328374359 0.364872794921564 no 2146 0.355139530213944 3270 5932993 SGTC_1185 1319-0113 81.3 µM -0.371595912039273 0.364833231336677 no 2147 0.355096866607561 3159 4672763 SGTC_341 1486-1430 230 µM -0.372035623013699 0.364681420767535 no 2148 0.354933163312614 3009 2054753 YPL210C SRP72 SGTC_277 nystatin 15.5 µM -0.372610397367542 0.364483011453264 no 2149 0.35471921664255 3008 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1298 1079-1278 263 µM -0.373139637674376 0.364300352370294 no 2150 0.354522259498468 3097 2840950 SGTC_180 1486-1293 102.781 µM -0.373293335128908 0.364247311850053 no 2151 0.354465068170256 3224 4140536 SGTC_1735 st034310 56.75 µM -0.373789562783803 0.364076082959622 no 2152 0.354280442632417 3238 871153 SGTC_728 3030-5151 22.5 µM -0.373980038724334 0.364010364314739 no 2153 0.354209583600775 3051 3125388 SGTC_2566 crystal violet carbinol 226 nM -0.374324209514693 0.363891627502602 no 2154 0.354081561287098 3189 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2928 9011484 9.79 µM -0.377168477249893 0.362910873767783 no 2155 0.353024202415899 3191 2994751 SGTC_191 3914-0123 66.505 µM -0.377394801885575 0.36283287154531 no 2156 0.352940114644003 3028 3144412 SGTC_1675 st018485 24.5 µM -0.378239694526487 0.362541731700504 no 2157 0.352626270008557 3103 3323024 SGTC_2298 7976326 193.81 µM -0.383227403911701 0.360824651329376 no 2158 0.350775580409127 3051 2235818 SGTC_1354 1498-1681 81 µM -0.383548295482361 0.360714276012869 no 2159 0.350656634169707 3176 5754243 SGTC_1811 st050069 61.5 µM -0.383973947857141 0.360567884598636 no 2160 0.350498878387877 3175 3877702 SGTC_1680 diphenhydramine 100 µM -0.386234487093227 0.359790777239848 no 2161 0.349661507305685 3099 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3286 9117135 37.221 µM -0.386739621267375 0.359617205937375 no 2162 0.349474490324428 3097 3438150 SGTC_696 1560-0013 611 µM -0.386955767220277 0.359542943950538 no 2163 0.349394477271477 3275 1650269 SGTC_1086 cerivastatin 2.18 µM -0.387297074985855 0.359425690502973 no 2164 0.349268145362937 3170 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_827 3253-0474 693 µM -0.38988377766011 0.358537481257288 no 2165 0.348311245054363 3212 5402065 SGTC_1650 st011916 45.8 µM -0.391921830074633 0.357838203135036 no 2166 0.347557986336811 3238 242528 SGTC_1102 cgs 12066b 26.1 µM -0.392666693811256 0.357582751073255 no 2167 0.347282836626395 3137 6438352 A 5-HT1B full agonist. SGTC_48 0382-0018 55 µM -0.393220625144298 0.357392820896903 no 2168 0.347078268751352 3341 762596 SGTC_1561 5-methoxyflavone 52.9 µM -0.39593597237653 0.356462303166802 no 2169 0.346076131440851 3140 94525 SGTC_745 0469-0705 296 µM -0.396068188945832 0.356417015851019 no 2170 0.346027362488068 3321 3486736 SGTC_2686 alizarin 95.37 µM -0.397055183868799 0.356079010652905 no 2171 0.345663383644988 3137 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1048 3161-0300 24.5 µM -0.39753703143794 0.355914038721231 no 2172 0.345485742197734 3160 2165101 SGTC_2122 5258151 111.688 µM -0.398723988160032 0.355507771092646 no 2173 0.345048295265793 3123 2173356 SGTC_1610 st001799 48.1 µM -0.399990599226884 0.355074420643184 no 2174 0.344581720420219 3038 621897 SGTC_802 4112-3352 742 µM -0.400214599216218 0.35499780216159 no 2175 0.344499231298696 3248 704594 SGTC_454 lyso-paf C-16 6.67 µM -0.400509375977823 0.354896983646045 no 2176 0.344390689544229 3158 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2349 9023730 187.07 µM -0.400891740319227 0.35476622387104 no 2177 0.344249915663491 3258 4126287 SGTC_2525 harmine 47.85 µM -0.40173080026197 0.354479344730198 no 2178 0.343941077244658 3119 5280953 A monoamine oxidase inhibitor SGTC_2428 5615643 7.78 µM -0.403668768289276 0.353817058656729 no 2179 0.343228154492826 3198 2253075 SGTC_1770 st043884 66.3 µM -0.403710863771539 0.353802677739753 no 2180 0.343212674952729 3093 670149 SGTC_1614 st002383 48.6 µM -0.404991096832698 0.35336541639527 no 2181 0.342742027657354 3196 1947235 SGTC_2292 7671323 168.05 µM -0.405548727984513 0.353175018913407 no 2182 0.342537104036077 3260 937504 SGTC_2568 diosmetin 100 µM -0.405844598509449 0.353074011852125 no 2183 0.342428393521973 3279 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2962 9082311 13.18 µM -0.406864665222026 0.352725851293132 no 2184 0.342053694649816 3072 16459453 SGTC_1615 st002656 86.5 µM -0.407059729063811 0.352659287785274 no 2185 0.341982059974471 3204 1584458 SGTC_611 3453-1652 23.7 µM -0.407402277519407 0.352542407603362 no 2186 0.341856277245962 3226 1560575 SGTC_678 1218-2179 85.9 µM -0.408914059725985 0.352026742243466 no 2187 0.3413013653555 3187 6820081 YOR116C RPO31 SGTC_1570 verbenone 133 µM -0.409581571000772 0.351799142223965 no 2188 0.341056459017065 3286 29025 A natural terpanoid with antifungal properties. SGTC_1721 st082152 9.2685 µM -0.412046709579151 0.350959069432609 no 2189 0.340152593639483 3133 5296051 SGTC_196 k015-0023 18.111 µM -0.41224732800168 0.350890734431782 no 2190 0.340079075395616 3120 5211998 SGTC_1458 k015-0034 6.33 µM -0.412612477308595 0.350766369009707 no 2191 0.339945279084141 3170 3598957 SGTC_285 1486-1325 46 µM -0.414074693315031 0.350268516310898 no 2192 0.339409702812854 3248 22310230 SGTC_3204 9114183 49.47 µM -0.414273206054816 0.350200946855726 no 2193 0.339337017109434 3073 17027248 SGTC_2847 9005661 71.43 µM -0.416733142997184 0.34936403140684 no 2194 0.338436804642727 3207 2991449 SGTC_3344 9148862 3.898 µM -0.41686229766041 0.349320110819106 no 2195 0.338389566015927 3284 4905352 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.417440117823153 0.349123640875481 no 2196 0.338178258060595 3387 6728940 SGTC_1938 st074717 56.4 µM -0.417511222146786 0.349099466833759 no 2197 0.338152258837811 3166 17250979 SGTC_651 3253-0966 34.4 µM -0.418153671410076 0.348881074760454 no 2198 0.337917382930232 3151 781462 SGTC_1793 st048256 72.231 µM -0.41840473881248 0.348795741338548 no 2199 0.337825611213232 3159 672022 SGTC_718 1130-0073 349 µM -0.420140492001808 0.348205998586411 no 2200 0.337191411878333 3305 6740020 SGTC_257 daunorubicin 18.5 µM -0.420454157390192 0.348099466143169 no 2201 0.337076855931938 3240 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2284 7945075 39.21 µM -0.422670913439308 0.34734691538271 no 2202 0.336267690019106 3268 1245402 SGTC_2262 9014885 67.46 µM -0.423118451056543 0.347195056884913 no 2203 0.336104420537208 3116 6457424 SGTC_2563 tomatine 8.54 µM -0.424802966783401 0.346623686994714 no 2204 0.335490157382241 3353 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_766 1391-0721 126 µM -0.425340130525328 0.34644156001291 no 2205 0.335294371521637 3275 1020919 YIL115C NUP159 SGTC_3355 9151058 44.0485 µM -0.427454896616994 0.345724887506531 no 2206 0.33452401502916 3251 17015728 SGTC_3078 9116413 49.47 µM -0.427732189102255 0.345630956848766 no 2207 0.334423055857128 3094 17177322 SGTC_3052 9092717 49.47 µM -0.431754994265984 0.344269334652719 no 2208 0.332959746430778 3294 25237534 SGTC_2000 st075254 36.4 µM -0.432256687771644 0.344099664587494 no 2209 0.332777431364886 3225 17234175 SGTC_1160 4092-0570 10.5 µM -0.434125598887448 0.343467885252036 no 2210 0.332098618616143 3168 4994975 SGTC_365 0121-0052 13.6 µM -0.43564811271978 0.342953527357419 no 2211 0.331546028688772 3278 3101739 SGTC_484 loperamide 105 µM -0.436768932830044 0.342575061353722 no 2212 0.331139465881544 3183 3955 An opioid-receptor agonist. SGTC_1034 k072-0165 12.7 µM -0.43762527703165 0.342286007058603 no 2213 0.330828972313042 3303 5835461 SGTC_1004 4084-0029 199 µM -0.437707173723697 0.342258368115579 no 2214 0.330799284275033 3285 716894 YLR208W SEC13 SGTC_1679 SEC14.276 6.7 µM -0.438317077723309 0.342052560967537 no 2215 0.330578223931871 3267 1005053 YMR079W SEC14 SGTC_677 0929-0063 136 µM -0.43905109650767 0.341804934506076 no 2216 0.330312256409606 3232 1539583 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.439678814804186 0.341593223245242 no 2217 0.330084874240818 3334 5393153 SGTC_1055 3448-0672 86 µM -0.439837411276269 0.341539741115419 no 2218 0.33002743481481 3306 748378 SGTC_1865 st057639 52.2 µM -0.440734775244464 0.341237190704617 no 2219 0.329702508946374 3185 688818 SGTC_2930 9013230 14.89 µM -0.441465575562968 0.340990873365502 no 2220 0.329437988902985 3269 2995857 SGTC_784 4579-0127 173 µM -0.442276421053814 0.340717655980346 no 2221 0.329144595619246 3354 1948547 SGTC_1953 st076800 12.1 µM -0.442409263706762 0.340672902118329 no 2222 0.329096538358198 3189 297591 SGTC_1753 st043925 64 µM -0.442748003503213 0.340558792943963 no 2223 0.32897400837142 3263 670181 SGTC_3131 9127911 49.47 µM -0.443408711850047 0.340336266217698 no 2224 0.328735067827941 3393 45595681 SGTC_2313 7726885 200 µM -0.444888015205306 0.339838238144492 no 2225 0.328200342045545 3264 726423 SGTC_2981 9013952 38.96 µM -0.445291475531091 0.339702456068525 no 2226 0.328054563715829 3202 2996344 SGTC_1976 st070609 63.5 µM -0.445669393406696 0.33957528901107 no 2227 0.327918038140108 3184 682556 SGTC_2794 7785382 27.27 µM -0.445960423691382 0.339477371542942 no 2228 0.327812917007357 3295 2205081 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.446107312700716 0.339427954683964 no 2229 0.327759865375606 3150 279621 SGTC_845 0330-0138 4.51 µM -0.447005351836884 0.339125893622159 no 2230 0.327435597869983 3243 9039800 SGTC_732 3970-1727 52.7 µM -0.447172850954917 0.339069565682619 no 2231 0.32737513102371 3290 1275699 SGTC_3273 9137859 49.47 µM -0.447449541934701 0.338976525712293 no 2232 0.32727525605428 3282 2377234 SGTC_2084 5306078 60.6385 µM -0.448065454994658 0.338769454364208 no 2233 0.327052979158583 3184 679340 SGTC_631 k072-0230 41.5 µM -0.448303243704697 0.338689522300185 no 2234 0.326967179985747 3263 5773147 SGTC_2912 7964298 10.93 µM -0.449365542319941 0.33833252211442 no 2235 0.326583992029068 3272 2975850 SGTC_178 4092-0806 87.505 µM -0.44963288417289 0.338242701044631 no 2236 0.326487586372244 3284 2169044 SGTC_1756 st041558 35.5 µM -0.449936089585858 0.338140841736001 no 2237 0.32637826204672 3358 3955792 SGTC_467 ro 31-8220 72.8 µM -0.450130288141685 0.338075608587634 no 2238 0.326308249277047 3194 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_147 4466-0538 29.23 µM -0.450328637930584 0.338008986018966 no 2239 0.326236746215797 3380 6742687 YHR072W ERG7 SGTC_496 calpeptin 138 µM -0.450859468076988 0.33783071349933 no 2240 0.326045418824302 3241 73364 A calpain inhibitor. SGTC_1226 3909-7979 35.4 µM -0.451200611166902 0.337716164149145 no 2241 0.325922484603463 3304 6615510 SGTC_2726 cimetidine 79.27 µM -0.451288969341555 0.337686497607878 no 2242 0.325890646962864 3224 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_170 4197-0004 226 µM -0.453708112206789 0.336874654960956 no 2243 0.325019463685343 3309 218692 SGTC_2323 6148992 148.28 µM -0.455839436747209 0.336160030611065 no 2244 0.324252721478478 3188 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_795 0685-0265 78 µM -0.458096503465413 0.335403890474497 no 2245 0.323441555434505 3314 302754 SGTC_630 4356-0227 183 µM -0.458573226663983 0.335244268509342 no 2246 0.32327033324601 3265 779312 SGTC_111 0083-0039 52.457 µM -0.462264382611814 0.334009361656777 no 2247 0.321945869105206 3178 759313 SGTC_2916 7875993 68.79 µM -0.462349842583521 0.333980791526405 no 2248 0.321915230965376 3361 1299250 SGTC_1530 rhein 70.4 µM -0.463114414998697 0.333725230085642 no 2249 0.321641179017474 3273 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_750 4073-0104 132 µM -0.464766237047407 0.333173365257486 no 2250 0.321049434316152 3265 22330957 SGTC_1430 4049-0248 69.1 µM -0.466043741772744 0.332746805320717 no 2251 0.320592095488938 3312 22774488 SGTC_837 0091-0265 12.5 µM -0.467151470989782 0.332377108724352 no 2252 0.320195755574784 3204 759367 SGTC_2327 6189656 200 µM -0.467773778250823 0.332169489679272 no 2253 0.319973187110025 3303 5349088 SGTC_803 4488-1585 147 µM -0.467800621313466 0.332160535243778 no 2254 0.319963588133818 3316 747204 SGTC_2487 5918373 44.05 µM -0.468979376239728 0.33176741517573 no 2255 0.319542188834218 3398 2876279 SGTC_2214 7179297 48.276 µM -0.469993865620821 0.331429226649438 no 2256 0.319179700141312 3271 769744 SGTC_1748 st037455 53.6035 µM -0.471152941396377 0.331043007211377 no 2257 0.318765760578142 3369 580690 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.47128992640364 0.33099737385512 no 2258 0.31871685418485 3253 6708630 An antioxidant. SGTC_2207 7258803 200 µM -0.472148857140136 0.330711298385316 no 2259 0.318410270688626 3314 3666799 SGTC_757 1066-0008 322 µM -0.472784133199429 0.330499776925758 no 2260 0.318183597608751 3320 6842497 SGTC_1727 st034309 9.9045 µM -0.474023730503634 0.330087196636751 no 2261 0.317741492513023 3413 870305 SGTC_2545 solidagenone 89.61 µM -0.475261175715764 0.329675538635662 no 2262 0.317300413993388 3212 6708572 An anti ulcer agent SGTC_2695 st077686 51.995 µM -0.477418856132915 0.328958241743774 no 2263 0.316531944816406 3271 2876092 SGTC_1309 pyrazolanthrone 13.4 µM -0.478237793440134 0.328686159767848 no 2264 0.316240482995037 3334 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3114 9122766 49.47 µM -0.478849862706504 0.328482866460177 no 2265 0.316022720539863 3284 17176985 SGTC_2304 7443016 91.4 µM -0.479913978430231 0.328129550856567 no 2266 0.315644280613801 3273 939854 SGTC_3207 9114163 49.47 µM -0.482076653845238 0.327411957225041 no 2267 0.314875746907242 3456 849233 SGTC_2888 9058547 12.99 µM -0.483160277530086 0.327052641365279 no 2268 0.314490968691581 3233 16476514 SGTC_2201 6605497 169.863 µM -0.483796972612352 0.32684159607691 no 2269 0.314264981906016 3288 670741 SGTC_2163 5671233 125 µM -0.484674652691396 0.326550762301826 no 2270 0.313953574689466 3446 701023 SGTC_1897 st060201 15 µM -0.485001043770343 0.326442634106853 no 2271 0.313837802556882 3269 611878 SGTC_389 tpck 16.7 µM -0.48571544925695 0.326206013782995 no 2272 0.313584464232389 3304 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2497 7-hydroxyflavone 100 µM -0.48584247378032 0.326163948941443 no 2273 0.313539428734005 3362 5281894 SGTC_749 1000-0129 128 µM -0.486664685892987 0.325891722567869 no 2274 0.313247987443794 3408 708470 SGTC_2987 9018338 71.43 µM -0.486828374051954 0.325837538093156 no 2275 0.313189980453723 3394 5055682 SGTC_2175 5807670 165.306 µM -0.489913013449998 0.324817141718928 no 2276 0.312097726990727 3340 241186 SGTC_1166 k206-0078 225 µM -0.492595271165231 0.323930919753392 no 2277 0.311149295011159 3317 5404595 SGTC_3095 9117207 49.47 µM -0.493397052826062 0.323666203232768 no 2278 0.31086603218922 3324 17015229 SGTC_327 1273-0057 3.96 µM -0.494053599731326 0.3234495038851 no 2279 0.310634163030169 3306 3108138 SGTC_1320 1313-0481 95.3 µM -0.494055360776676 0.323448922716355 no 2280 0.310633541192291 3422 6813365 YLR208W SEC13 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.494498649513782 0.323302645150377 no 2281 0.310477029938564 3331 2346 DNA damaging agent; causes G2/M arrest. SGTC_1162 k048-0130 20.1 µM -0.495273923109198 0.323046884021952 no 2282 0.310203387790701 3269 6797406 SGTC_2620 irigenin 100 µM -0.495549718669417 0.322955919810283 no 2283 0.310106067753938 3406 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1516 st013856 110 µM -0.496626347510878 0.322600922327132 no 2284 0.30972628486017 3335 5281404 A mutagen and neurotoxin. SGTC_1466 k213-0079 57.5 µM -0.496891162997605 0.322513629313719 no 2285 0.309632901783102 3322 3657981 SGTC_1357 1503-1303 39.5 µM -0.496897995408019 0.322511377227099 no 2286 0.309630492602038 3297 292895 SGTC_1719 st032227 49.2 µM -0.498010831122743 0.32214465331995 no 2287 0.309238204032445 3263 3125804 SGTC_259 usnic acid 108.925 µM -0.499214210447973 0.321748286444258 no 2288 0.308814242307053 3441 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2319 6033012 152.6 µM -0.499528697602079 0.321644734644923 no 2289 0.308703487504819 3233 847246 SGTC_2137 5261020 140 µM -0.499890011810038 0.321525781113258 no 2290 0.308576262818737 3278 763655 SGTC_1481 3346-2004 36 µM -0.500509919135702 0.321321734995638 no 2291 0.308358036770475 3377 2770522 SGTC_2518 prenyletin 46.28 µM -0.501427153451016 0.321019920882664 no 2292 0.308035266876508 3344 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2964 9083345 53.42 µM -0.501788713339807 0.320900982797155 no 2293 0.307908076639021 3290 17741579 SGTC_2517 totarol 10 µM -0.501957142957733 0.320845582769162 no 2294 0.307848834019176 3334 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1342 1486-1464 234 µM -0.502035240644294 0.320819896158378 no 2295 0.307821366015812 3291 3253938 SGTC_2280 7785178 200 µM -0.503373205621604 0.320379967960861 no 2296 0.307350953168338 3271 2954328 SGTC_2641 levomentholum 100 µM -0.505313101558341 0.319742570651632 no 2297 0.306669471091404 3340 16666 SGTC_1088 bifonazole 369 nM -0.505453761149468 0.319696374379255 no 2298 0.306620083560381 3343 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_545 4218-0007 221 µM -0.505977956868973 0.319524239495357 no 2299 0.306436062111957 3381 2840508 SGTC_932 2857-0803 154 µM -0.506735866059369 0.319275426758112 no 2300 0.306170080716357 3464 674898 SGTC_286 k060-0067 22.9 µM -0.507402538582964 0.319056633214483 no 2301 0.305936202433501 3310 5985051 SGTC_2729 fluphenazine 10.66 µM -0.507877560807469 0.318900775336095 no 2302 0.305769606080097 3267 3372 An atypical antipsychotic. SGTC_2107 5363541 170.161 µM -0.508463078466087 0.318708707246446 no 2303 0.30556431286766 3379 244052 SGTC_1468 k284-1086 134 µM -0.509490629013653 0.31837175628321 no 2304 0.305204182587525 3337 15996457 SGTC_2288 7946289 167.31 µM -0.511177757825972 0.317818844451557 no 2305 0.304613295869788 3450 1246052 SGTC_1646 st011709 75.6 µM -0.511721759995663 0.317640648626481 no 2306 0.304422877372931 3391 5757843 SGTC_1512 0259-0544 12.2 µM -0.512064204459405 0.317528497620409 no 2307 0.304303037825243 3339 18476 SGTC_1889 st059080 5.18 µM -0.512109606833374 0.317513629541108 no 2308 0.304287150695029 3423 176925 Isolated from Daphnopsis sellowiana. SGTC_1317 1273-0028 910 nM -0.512398631573438 0.317418988468577 no 2309 0.304186024255228 3304 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_804 1595-0054 20.9 µM -0.514207113155612 0.316827072840457 no 2310 0.303553597561688 3286 761523 Stimulates phospholipase C. SGTC_2244 6635614 200 µM -0.515167356773439 0.316512975663537 no 2311 0.303218038834634 3147 836499 SGTC_469 w7 172 µM -0.51547862116023 0.316411188979262 no 2312 0.303109302582841 3379 45115570 A P450 inhibitor. SGTC_1966 st070145 16.1 µM -0.516384884601439 0.316114910636127 no 2313 0.302792810352497 3267 3748532 SGTC_2083 5306046 65.942 µM -0.516674699961931 0.316020188237054 no 2314 0.302691630061659 3343 539837 SGTC_2403 6032726 181.2 µM -0.518324405044438 0.315481233659864 no 2315 0.302115974036718 3331 2881040 SGTC_3132 9126706 49.47 µM -0.518911128279801 0.315289647138914 no 2316 0.301911358562752 3456 850858 SGTC_1272 0839-0021 27 µM -0.518925665682688 0.315284900777287 no 2317 0.301906289539467 3364 5027250 SGTC_223 busulfan 5 mM -0.519238571355143 0.315182746627853 no 2318 0.30179719224214 3391 2478 A DNA alkylator. SGTC_2103 5378138 10 µM -0.519743871105706 0.315017811522664 no 2319 0.301621052492287 3439 244142 SGTC_2671 danthron 100 µM -0.51982824121236 0.31499027583248 no 2320 0.30159164687128 3356 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1916 st067606 49.2 µM -0.520583445466745 0.314743847253391 no 2321 0.301328492022378 3341 19590279 SGTC_838 0109-0203 71.4 µM -0.520621731082459 0.314731356577427 no 2322 0.301315153954462 3367 759422 SGTC_1548 st061468 90.8 µM -0.522004819825701 0.314280266339575 no 2323 0.300833487370594 3370 390799 SGTC_3226 9131256 49.47 µM -0.522028531764494 0.314272535177301 no 2324 0.300825232615332 3347 17178073 SGTC_778 3456-2434 196 µM -0.522531337281721 0.314108617070994 no 2325 0.300650216729884 3401 5539063 SGTC_3247 9135149 49.47 µM -0.523322682490834 0.313850707280703 no 2326 0.300374859461377 3349 8934436 YOR116C RPO31 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.525198405687281 0.313239747818707 no 2327 0.299722636564254 3440 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2256 7954252 200 µM -0.526148587300949 0.3129304505812 no 2328 0.299392486178282 3356 2972920 SGTC_2011 4012611 177 µM -0.527010217829922 0.312650091727826 no 2329 0.299093246435051 3313 2049887 SGTC_1928 4'-methoxychalcone 40.3 µM -0.527561661906661 0.312470718745803 no 2330 0.298901804096731 3481 641818 SGTC_1133 3473-0247 50 µM -0.527901300172706 0.312360263772906 no 2331 0.298783921129034 3299 711311 SGTC_2095 5432005 200 µM -0.529404308934931 0.311871667414889 no 2332 0.298262504849027 3312 783734 SGTC_2338 7999974 200 µM -0.529740642863578 0.311762377645413 no 2333 0.29814588232118 3411 315925 SGTC_1508 1080-0625 72.9 µM -0.53041557918445 0.311543110996168 no 2334 0.297911913374928 3387 767111 SGTC_3186 9110464 49.47 µM -0.531277884571906 0.311263070952579 no 2335 0.29761311416656 3449 17018021 SGTC_2062 5245942 200 µM -0.532355975802826 0.310913106475209 no 2336 0.297239735093168 3452 1376160 SGTC_2372 9071633 200 µM -0.53294973485977 0.310720436418646 no 2337 0.297034187925665 3436 21321366 SGTC_1747 st037496 66.6 µM -0.53319510452705 0.310640831078544 no 2338 0.296949264983538 3330 723305 SGTC_1330 1469-0054 61.8 µM -0.53739723751602 0.309278910541852 no 2339 0.295496625554766 3432 7102664 SGTC_2618 avocadyne 43.43 µM -0.537398774780403 0.309278412788716 no 2340 0.295496094734809 3360 3015189 SGTC_3270 9137563 49.47 µM -0.537809347527112 0.309145485357218 no 2341 0.295354338981912 3383 17015724 SGTC_2371 9071574 200 µM -0.538118186355911 0.309045511860402 no 2342 0.295247728854843 3414 45596039 SGTC_2431 5490079 200 µM -0.538596320983 0.30889076391141 no 2343 0.295082713334327 3374 5722345 SGTC_1104 tacrolimus 29.8 µM -0.53918259304933 0.308701063645676 no 2344 0.29488043503027 3448 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_158 k038-0087 26.446 µM -0.54052117308568 0.308268130164902 no 2345 0.294418831647836 3343 X158 SGTC_2744 captopril 92.04 µM -0.540742936377405 0.308196431559717 no 2346 0.294342389782968 3390 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1568 digitonin 820 nM -0.541704657099523 0.307885580973546 no 2347 0.294010990500665 3488 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_705 1124-0212 310 µM -0.542770967237385 0.307541085755086 no 2348 0.293643752548355 3458 9554485 SGTC_3011 9081274 71.4286 µM -0.543356137655133 0.307352105512935 no 2349 0.293442309729658 3369 6625322 SGTC_432 NS 1619 61.3 µM -0.544485713451871 0.306987454717625 no 2350 0.293053638474911 3451 4552 A K+/calcium channel activator. SGTC_332 4112-0506 40.9 µM -0.5485661737717 0.305671788307261 no 2351 0.29165160245193 3405 2790355 SGTC_1050 3232-1156 69.3 µM -0.548856426530299 0.305578297083839 no 2352 0.291551991557182 3368 700529 SGTC_3212 9128307 49.47 µM -0.550247072671148 0.30513054200282 no 2353 0.291074960491752 3229 27243542 SGTC_2435 5706476 10.6 µM -0.550272915702825 0.305122223916501 no 2354 0.291066099050392 3470 5725375 SGTC_275 trichlorophene 5.69 µM -0.55142567063559 0.30475128958977 no 2355 0.290670953607674 3447 62616 SGTC_2640 pentamidine 10.38 µM -0.551537870467777 0.304715196553435 no 2356 0.290632506752898 3440 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1485 3909-9022 254 µM -0.552479395017684 0.304412396872641 no 2357 0.290309973868271 3459 714516 SGTC_1791 st048313 56.1 µM -0.553678094736161 0.304027082124263 no 2358 0.289899584635909 3424 1204976 SGTC_685 1278-0033 54.9 µM -0.554623819433893 0.303723238178582 no 2359 0.289575996568869 3493 3590572 SGTC_2818 7996756 12.99 µM -0.555716616165067 0.303372311565749 no 2360 0.289202297836424 3378 2241621 SGTC_1297 1068-0111 14.1 µM -0.556180863123782 0.303223284156363 no 2361 0.28904361005875 3376 767057 SGTC_420 mitomycin C 81.9 mM -0.557116782107059 0.302922945381555 no 2362 0.288723821059121 3402 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2217 6934799 96.0675 µM -0.557603678681379 0.302766751709956 no 2363 0.288557521959127 3433 675606 SGTC_353 1988-1175 58.3 µM -0.557939541928613 0.302659029703763 no 2364 0.288442834468816 3322 2788357 SGTC_2890 9046729 58.44 µM -0.558125470134065 0.302599404010914 no 2365 0.288379354656828 3329 903329 SGTC_1657 st012939 43.4 µM -0.558506022817177 0.302477380217344 no 2366 0.288249446482238 3484 24207257 SGTC_3175 9106517 49.47 µM -0.559473306836152 0.302167321028137 no 2367 0.287919371819007 3433 41468073 SGTC_2283 7944793 200 µM -0.561504451940157 0.301516710033741 no 2368 0.287226848119508 3425 2970533 SGTC_707 0865-0008 204 µM -0.562759242936279 0.30111509396822 no 2369 0.286799418511277 3425 723043 SGTC_595 3909-8003 73.7 µM -0.563009075768575 0.301035159731328 no 2370 0.286714351935021 3485 699517 SGTC_901 1112-0062 60.1 µM -0.563712054328333 0.300810292453928 no 2371 0.286475056173504 3429 1908457 SGTC_3167 9103034 49.47 µM -0.564627081850411 0.300517708974858 no 2372 0.286163720416036 3468 5127859 SGTC_1994 st072947 40.9 µM -0.568142369309298 0.299394879873902 no 2373 0.284969150054148 3492 5286565 YDL195W SEC31 SGTC_2306 7482397 179.52 µM -0.569557035609118 0.298943554302 no 2374 0.284489088002339 3499 891448 SGTC_2628 lathosterol 100 µM -0.571201257906471 0.298419381408821 no 2375 0.283931612818466 3519 6710616 SGTC_1667 st014849 34.6 µM -0.571853055459906 0.298211706230484 no 2376 0.283710765008345 3487 5348460 SGTC_908 3448-7491 47.7 µM -0.574474133481407 0.297377245917396 no 2377 0.28282349974684 3492 1203031 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.576774444512709 0.296645786718259 no 2378 0.282045917608916 3527 368090 SGTC_2440 5628896 157.78 µM -0.576897190870537 0.296606778663927 no 2379 0.282004454181116 3451 5522048 SGTC_2127 5253358 187.912 µM -0.577676292900728 0.296359239529815 no 2380 0.28174134384533 3401 20612 SGTC_2287 7945887 168.79 µM -0.578058088867024 0.296237968515118 no 2381 0.281612450850349 3460 1245853 SGTC_877 0771-0151 33.1 µM -0.579776713894172 0.295692358465646 no 2382 0.281032601369864 3433 6166523 SGTC_3239 9133757 49.47 µM -0.58045762738787 0.295476317391786 no 2383 0.280803026603025 3469 17036923 SGTC_927 2425-1185 123 µM -0.580629483628822 0.295421802107174 no 2384 0.280745098399414 3419 730375 SGTC_3177 9107506 49.47 µM -0.580934521369856 0.29532505112118 no 2385 0.280642292462128 3473 8897194 SGTC_3335 9143315 29.6265 µM -0.581663341036923 0.295093945270806 no 2386 0.280396734366929 3416 4899691 SGTC_577 r071-0003 38.6 µM -0.584296545347423 0.294259661442662 no 2387 0.279510408018765 3483 4568517 YMR134W ERG29 SGTC_1281 0884-0031 11.8 µM -0.5870178504322 0.293398611015807 no 2388 0.278595859115197 3483 1548255 SGTC_2164 5685496 200 µM -0.587230853233126 0.293331263910479 no 2389 0.278524336815939 3511 759046 SGTC_861 0443-0273 110 µM -0.588624773198861 0.292890712030641 no 2390 0.278056505856296 3476 6149169 SGTC_569 4130-2812 160 µM -0.589200484299605 0.29270884675771 no 2391 0.277863396162461 3438 743552 SGTC_1750 st081859 2.357 µM -0.589827950283675 0.292510692036746 no 2392 0.27765300101635 3533 5291695 SGTC_3341 9147222 25.867 µM -0.590012300885563 0.292452485685174 no 2393 0.277591201349222 3498 1939759 SGTC_1219 1469-0211 33.1 µM -0.590880928155232 0.292178300180857 no 2394 0.277300102773326 3490 6822282 SGTC_3150 9097574 49.47 µM -0.591685803074946 0.291924345162748 no 2395 0.277030502517991 3496 17217476 SGTC_3268 9137683 49.47 µM -0.593823901701158 0.291250229668822 no 2396 0.276314950422414 3494 1953228 SGTC_2486 5283202 22.39 µM -0.593984428351128 0.291199646983692 no 2397 0.276261263987567 3435 1377751 SGTC_1643 st009866 20.2 µM -0.594975539364119 0.290887434223253 no 2398 0.275929910824673 3506 3156273 YOR207C RET1 SGTC_953 1188-0045 9.7 µM -0.595179650010684 0.290823156168623 no 2399 0.275861695787582 3519 6144426 SGTC_2935 9038016 29.96 µM -0.597688888715443 0.290033495624383 no 2400 0.275023770400031 3521 6463195 SGTC_1182 1222-0449 220 µM -0.598341255086717 0.289828359862154 no 2401 0.274806127256434 3488 658318 SGTC_1017 4239-0030 168 µM -0.600035820740829 0.289295824145981 no 2402 0.274241181526208 3442 1149593 SGTC_2215 7188065 200 µM -0.600053653137098 0.289290222567079 no 2403 0.274235239492548 3532 940217 SGTC_2365 9042475 200 µM -0.600305494368556 0.289211118703007 no 2404 0.274151328841076 3506 6464479 SGTC_2025 5147754 141 µM -0.600330754443409 0.289203185021144 no 2405 0.274142913169582 3514 315777 YLR208W SEC13 SGTC_2648 atorvastatin 78.68 µM -0.601127299668249 0.288953058673178 no 2406 0.273877600855667 3532 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1398 3558-0053 112 µM -0.603074198404796 0.288342134037577 no 2407 0.273229664999439 3418 4532369 SGTC_1323 1348-1351 11.2 µM -0.603092606298022 0.28833636066341 no 2408 0.273223542403229 3429 6989654 SGTC_3228 9131799 49.47 µM -0.604681373984626 0.287838271742033 no 2409 0.272695363210452 3476 17015818 SGTC_2689 tacrolimus 100 µM -0.605897023199768 0.287457432518758 no 2410 0.272291568152346 3494 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1060 3448-7350 82 µM -0.606438635239506 0.287287832786275 no 2411 0.272111759778914 3510 570178 SGTC_2309 7664088 163.95 µM -0.60667281234824 0.287214517517635 no 2412 0.272034034212267 3549 704922 SGTC_40 0327-0103 19.753 µM -0.607536402326774 0.286944224662166 no 2413 0.271747496104323 3450 409036 SGTC_1504 k297-0033 30 µM -0.608871677588176 0.286526537586584 no 2414 0.271304749290292 3385 4388117 SGTC_2523 spermine 47.74 µM -0.608913123931065 0.286513577384734 no 2415 0.2712910123835 3505 1103 A DNA binding polyamine. SGTC_2678 equilin 100 µM -0.60903323938283 0.286476019055666 no 2416 0.271251203476679 3563 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_822 1487-0950 154 µM -0.610020911259204 0.286167277252639 no 2417 0.270923977711151 3545 1958375 SGTC_398 bronopol 33.3 µM -0.612053744540853 0.285532320563845 no 2418 0.270251099832474 3480 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1903 st060211 78.3 µM -0.612843513843903 0.285285816663121 no 2419 0.269989907858293 3566 688960 SGTC_1972 st070201 17.4 µM -0.613948156315733 0.284941204277026 no 2420 0.269624793280338 3542 2829099 SGTC_2760 etidronate 98.04 µM -0.614937035402739 0.284632874811787 no 2421 0.269298151644215 3508 3305 A chelator and antioxidant. SGTC_3192 9110362 49.47 µM -0.616002477280148 0.284300851680833 no 2422 0.268946442398636 3604 16649480 SGTC_37 0566-0070 1.56 µM -0.616115041268675 0.284265784235269 no 2423 0.268909297772191 3535 1626686 SGTC_2255 7941087 197.44 µM -0.616783515045751 0.284057574917806 no 2424 0.268688763355331 3589 935561 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.618454739638635 0.283537358532949 no 2425 0.268137811941323 3610 688801 SGTC_1108 betulinic acid 729.144 nM -0.61978827115083 0.283122586517578 no 2426 0.267698595784519 3545 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_998 3996-0085 177 µM -0.6210786996277 0.282721498352454 no 2427 0.267273921636613 3545 715391 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.621258075265081 0.28266576682839 no 2428 0.26721491685275 3683 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2150 5556613 200 µM -0.621329389633033 0.282643611114549 no 2429 0.267191460148798 3540 743190 SGTC_846 0335-0850 148 µM -0.621992938273257 0.282437502022334 no 2430 0.266973255732299 3536 6819598 SGTC_1942 st076330 65.2 µM -0.62476988639434 0.281575721532724 no 2431 0.266061048782276 3605 24208414 SGTC_2432 5630864 12.22 µM -0.625117125167969 0.281468050922374 no 2432 0.265947094547008 3547 5714970 SGTC_1764 st044502 93.5 µM -0.625160968637761 0.281454457501887 no 2433 0.265932708081936 3563 8407 SGTC_3051 9093778 49.47 µM -0.625516656941438 0.28134419006004 no 2434 0.265816009785188 3544 17217378 SGTC_1929 genistein trimethyl ether 50.5 µM -0.627897144410478 0.280606748975334 no 2435 0.265035660892215 3598 136420 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.628517443578615 0.280414742850541 no 2436 0.264832511598474 3612 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_946 3434-1334 87.4 µM -0.629074016305908 0.280242516635874 no 2437 0.264650300249192 3520 4047976 SGTC_424 splitomicin 100 mM -0.630373459109927 0.279840615825081 no 2438 0.264225135699091 3530 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1275 0867-0008 21.1 µM -0.630543239425092 0.279788125632332 no 2439 0.264169611000655 3525 3422836 SGTC_1575 cyproterone acetate 48 µM -0.630673815138682 0.279747759394128 no 2440 0.26412691175951 3493 9880 An androgen receptor antagonist and liver toxin. SGTC_1684 st024538 14.6195 µM -0.630859863739836 0.27969024912293 no 2441 0.264066078540859 3519 6732859 SGTC_151 3013-0144 2.285 µM -0.632184610431757 0.279280917019605 no 2442 0.263633126137455 3547 906558 YHR107C CDC12 SGTC_1339 1486-1321 22.7 µM -0.632214334772624 0.279271735866622 no 2443 0.263623415813468 3545 3469382 SGTC_519 k048-0011 62.8 µM -0.633576141983667 0.278851262866233 no 2444 0.263178737487688 3556 6836379 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.639579715877728 0.277001274492601 no 2445 0.261222936572779 3588 688798 SGTC_2340 7987427 183.45 µM -0.639987418159438 0.27687586009996 no 2446 0.261090389590908 3542 2239331 SGTC_1364 1653-0028 37.6 µM -0.640549508266074 0.276702999663207 no 2447 0.260907706706851 3544 5718652 SGTC_322 k048-0136 19.3 µM -0.641595764019531 0.276381383907508 no 2448 0.260567842040429 3586 6823282 SGTC_1676 st018489 23.4 µM -0.642250912367561 0.276180086745863 no 2449 0.26035514041464 3553 3696235 SGTC_531 3788-1495 174 µM -0.642333522139434 0.276154709646052 no 2450 0.260328326531057 3564 2896655 SGTC_2063 5246145 200 µM -0.642802722837673 0.276010596440437 no 2451 0.260176058067535 3605 711240 SGTC_1151 3909-8316 15.3 µM -0.642944575348257 0.275967034254354 no 2452 0.260130032085591 3601 800431 SGTC_2050 5263056 171 µM -0.642999035831107 0.275950310613579 no 2453 0.260112362754169 3580 763468 YGL055W OLE1 SGTC_410 α-linolenic acid 100 µM -0.644660913224787 0.275440223365905 no 2454 0.259573475655941 3625 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3309 9129340 25.759 µM -0.644792907233782 0.275399729764206 no 2455 0.25953069946732 3591 17158987 SGTC_1529 apigenin 74 µM -0.644885026510032 0.275371470813475 no 2456 0.259500847909155 3658 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2374 9071832 200 µM -0.646173310139232 0.27497642032678 no 2457 0.259083561188802 3568 17381698 SGTC_428 3448-4153 16.5 µM -0.649026502279208 0.274102487944211 no 2458 0.258160623109245 3561 3834874 SGTC_855 0428-0020 25 µM -0.649577086742918 0.273934002082143 no 2459 0.25798271886985 3572 6812414 SGTC_652 0437-0092 114 µM -0.651158060158877 0.27345048880544 no 2460 0.257472230202228 3583 3091274 SGTC_1830 st055982 50.3 µM -0.651636599072142 0.273304219328306 no 2461 0.257317815824723 3574 455313 An antimicrobial agent. SGTC_141 0443-0274 32.331 µM -0.652248649671044 0.27311719736744 no 2462 0.257120390221246 3692 1627241 SGTC_2205 7238770 200 µM -0.654732771876065 0.272358785366849 no 2463 0.256319910736821 3618 279867 SGTC_509 pifithrin 175 µM -0.657356676553944 0.271558835034297 no 2464 0.255475800763979 3637 4817 A p53 inhibitor. SGTC_2041 5107442 45.335 µM -0.657444441622321 0.271532098317457 no 2465 0.255447591870888 3627 793005 SGTC_201 4262-0159 12.803 µM -0.657922635207113 0.271386444642991 no 2466 0.255293922510679 3563 1341029 SGTC_1694 st024011 44.9 µM -0.659175006727236 0.271005167577072 no 2467 0.254891697200803 3659 2787533 SGTC_2142 5622915 118.518 µM -0.659229660042885 0.270988534787154 no 2468 0.254874151701063 3592 5322196 SGTC_219 mitoxanthrone 164.414 µM -0.660734405314818 0.270530791763548 no 2469 0.254391327709691 3584 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2812 7970281 58.44 µM -0.662138985908959 0.270103867658464 no 2470 0.253941076263014 3637 2233435 SGTC_3319 9138450 16.7555 µM -0.663050000540297 0.269827143880051 no 2471 0.253649265746949 3575 2029690 SGTC_2893 9048488 25.97 µM -0.664488730903821 0.269390413952999 no 2472 0.253188779566775 3576 6467338 SGTC_1460 k062-0059 9.15 µM -0.664558549166533 0.269369229477659 no 2473 0.253166444426136 3550 1373085 SGTC_1350 1495-0454 146 µM -0.665735055576864 0.269012375903098 no 2474 0.252790231243776 3640 1069057 SGTC_1328 1441-0025 69.2 µM -0.666176456171118 0.268878553147063 no 2475 0.252649159896986 3570 4562601 SGTC_2712 st079126 47.7 µM -0.666495995320554 0.268781696910146 no 2476 0.252547061269594 3595 3152970 SGTC_1101 ebselen 5.29 µM -0.666549051215908 0.268765616713913 no 2477 0.252530111041055 3684 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3148 9097893 49.47 µM -0.667463203936064 0.268488630956393 no 2478 0.25223815288006 3558 17174100 SGTC_1200 1643-0193 18.4 µM -0.668362575288626 0.268216264033362 no 2479 0.251951089319622 3624 5403974 SGTC_1539 benzyladenosine 56 µM -0.668739420951547 0.268102180891703 no 2480 0.251830858070252 3609 92208 A nucleotide analog. SGTC_1841 st054148 70 µM -0.669058028319163 0.268005747387839 no 2481 0.251729231173214 3581 675442 SGTC_3214 9129694 49.47 µM -0.671713603805429 0.267202659263149 no 2482 0.250883019612873 3598 17158655 SGTC_3073 9114972 49.47 µM -0.674854675167858 0.266254320025297 no 2483 0.249884049666242 3564 41905075 SGTC_917 harmaline 728.087 nM -0.674872520624747 0.26624893707 no 2484 0.249878380228276 3611 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1909 st060837 51.5 µM -0.676105819415077 0.265877054757836 no 2485 0.249486731073906 3604 678937 SGTC_2768 sulfasalazine 50.2 µM -0.680165442009057 0.264654799969898 no 2486 0.248199855633258 3684 5384001 An antioxidant and salicylic acid derivative. SGTC_2408 sulbentine 18.36 µM -0.680243876381546 0.264631213436972 no 2487 0.248175027323284 3625 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2543 pimpinellin 60.67 µM -0.681774594567065 0.264171114926651 no 2488 0.247690745541248 3574 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3028 9087778 49.47 µM -0.686012825677115 0.262899329994714 no 2489 0.246352510307533 3614 17217395 SGTC_2088 5278280 127.392 µM -0.687117084030454 0.262568485080748 no 2490 0.246004474650771 3697 791502 SGTC_1303 1160-0052 261 µM -0.688561005735395 0.262136195934692 no 2491 0.245549783571266 3662 3562476 SGTC_442 cape 100 µM -0.688781226358252 0.262070297153895 no 2492 0.245480475775859 3621 5281787 SGTC_939 1165-0479 45.3 µM -0.689031641072117 0.26199537341712 no 2493 0.245401678074398 3610 1377347 SGTC_537 1334-0398 209 µM -0.689513794231094 0.261851144790644 no 2494 0.245249997800715 3650 5846986 SGTC_2807 7945238 51.95 µM -0.690194757480168 0.261647514607354 no 2495 0.245035859871962 3685 17148797 SGTC_2453 5731132 22.18 µM -0.690564430598648 0.261537004351525 no 2496 0.244919653390255 3695 1362040 SGTC_1671 st016596 74.5 µM -0.690956465383705 0.261419835473313 no 2497 0.244796449942167 3700 2829167 SGTC_1363 1636-0063 10.4 µM -0.691821526928689 0.261161386748057 no 2498 0.244524708038243 3692 6072185 SGTC_102 gallobenzophenone 83.616 µM -0.692804587787659 0.2608678436328 no 2499 0.244216096357234 3688 70837 SGTC_556 4058-0063 51.5 µM -0.692931184663673 0.260830053997039 no 2500 0.244176369147132 3724 6615692 SGTC_3071 9117417 49.47 µM -0.693889419746964 0.260544108637011 no 2501 0.243875779612779 3600 45595590 YGL055W OLE1 SGTC_289 k017-0060 526 µM -0.695081359295878 0.260188649288825 no 2502 0.243502157986688 3651 5512909 SGTC_2977 9011197 71.43 µM -0.69515370133737 0.260167083545679 no 2503 0.243479491834399 3666 2704722 SGTC_3195 9113082 49.47 µM -0.69541918440473 0.260087948807987 no 2504 0.243396320653143 3635 17018038 SGTC_2749 bexarotene 57.39 µM -0.695749797338914 0.259989417623547 no 2505 0.243292766894975 3673 82146 An retinoic acid receptor inhibitor. SGTC_670 4204-0025 119 µM -0.696302317211737 0.259824795422896 no 2506 0.243119761163183 3679 719039 SGTC_626 0214-0009 33 µM -0.697098471861382 0.259587677340405 no 2507 0.242870585235522 3700 3437874 SGTC_3019 9081971 49.47 µM -0.697133050945822 0.259577381212462 no 2508 0.242859766003668 3697 16451803 SGTC_2594 a-mangostin 100 µM -0.697177681440336 0.259564092529128 no 2509 0.242845802234993 3690 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_194 1486-1323 56.904 µM -0.69756744436827 0.259448055953203 no 2510 0.242723873602378 3662 5178754 SGTC_1168 k815-0004 80.5 µM -0.698154415688525 0.259273358909885 no 2511 0.242540315274319 3663 642433 SGTC_1723 st034307 2.5525 µM -0.69822886109439 0.259251206478149 no 2512 0.242517039997086 3712 867466 SGTC_1983 st071813 46.9 µM -0.700026711513705 0.258716524288189 no 2513 0.241955311525831 3706 11838595 SGTC_2067 5224629 34.075 µM -0.701631269594852 0.258239809896274 no 2514 0.241454572812877 3667 2835000 SGTC_870 0573-2213 57.6 µM -0.702725742197225 0.257914903357086 no 2515 0.241113341017233 3677 3916321 SGTC_464 bw-b 70c 158 µM -0.703351959617887 0.257729099086975 no 2516 0.240918218574348 3696 5353454 SGTC_2734 clemastine 41.6 µM -0.703495917512363 0.257686395326124 no 2517 0.240873375027057 3664 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1950 st077106 7.18 µM -0.705439746522827 0.25711013654788 no 2518 0.240268308177001 3681 13831864 SGTC_3252 9135871 49.47 µM -0.705661022243502 0.257044580657733 no 2519 0.240199482951869 3703 17682838 SGTC_458 nppb 133 µM -0.70637630853748 0.256832727022312 no 2520 0.239977075036625 3718 4549 A chloride channel blocker. SGTC_1728 st035614 33.7865 µM -0.706938209593138 0.256666366813198 no 2521 0.23980243882908 3694 15945546 SGTC_2528 xanthyletin 44.79 µM -0.70909217442293 0.256029169667059 no 2522 0.239133639442849 3737 65188 An natural product with antifungal activity of unknown mechanism. SGTC_367 0335-0881 7.1 µM -0.709826200819442 0.255812214813436 no 2523 0.238905959638113 3663 23828853 SGTC_2252 omeprazole 400 µM -0.710215552152295 0.255697173907829 no 2524 0.238785239042724 3626 4594 A proton pump inhibitor. SGTC_502 l-744,832 89.3 µM -0.710813559232048 0.255520534503308 no 2525 0.238599888550466 3657 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_637 1181-0519 7.26 µM -0.711265889509956 0.255386967488425 no 2526 0.238459742466694 3704 6252091 YGR060W ERG25 SGTC_2897 9048598 12.99 µM -0.715032234656002 0.254276235096255 no 2527 0.237294562610718 3702 6467404 SGTC_2009 4012297 12.05 µM -0.715488994290253 0.254141704575117 no 2528 0.237153469521842 3696 45595307 SGTC_2943 9068529 45.32 µM -0.715772615837142 0.25405818762479 no 2529 0.237065882003012 3720 3270634 SGTC_992 3909-8734 162 µM -0.716549510365937 0.253829492225479 no 2530 0.236826053830282 3713 4288319 SGTC_391 gliotoxin 8.33 µM -0.717381977207905 0.253584557928164 no 2531 0.236569218560576 3758 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1187 1391-0724 117 µM -0.71800381113229 0.253401678583889 no 2532 0.236377468459322 3765 6997986 SGTC_1602 st001878 87.6 µM -0.718656485302176 0.253209803809564 no 2533 0.236176300457704 3719 595405 YLR310C CDC25 SGTC_2101 5377231 179.231 µM -0.719978746127084 0.252821316590992 no 2534 0.235769040860881 3718 2844213 SGTC_3158 9100007 49.47 µM -0.720426976949382 0.252689695255122 no 2535 0.23563107259381 3714 19297233 SGTC_375 3970-0961 9.27 µM -0.720475410836473 0.252675474982647 no 2536 0.235616167005148 3687 2898222 SGTC_2227 7312221 64.1025 µM -0.720746273494729 0.252595957010599 no 2537 0.235532818275433 3733 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_889 0919-1524 82.7 µM -0.721139427008611 0.252480561199056 no 2538 0.235411867660262 3732 3905452 SGTC_1420 4'-methoxyflavone 42 µM -0.72431847717116 0.251548488907662 no 2539 0.234435117950594 3696 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_972 1319-0219 195 µM -0.724358256840274 0.251536837351581 no 2540 0.234422910037114 3685 23903702 SGTC_1472 k841-0093 193 µM -0.724829567787127 0.251398811003199 no 2541 0.23427829701611 3792 X1472 SGTC_2443 5493264 126.67 µM -0.725170310374256 0.251299047351857 no 2542 0.234173777237297 3742 5340055 SGTC_179 1273-0063 6.77 µM -0.72603166337888 0.251046951161058 no 2543 0.233909679970471 3709 3108139 SGTC_14 0354-0009 295 µM -0.726457421683056 0.25092239192968 no 2544 0.233779200262575 3765 1713507 SGTC_1849 st056239 19.2 µM -0.727862811606853 0.250511465390479 no 2545 0.233348784952697 3717 5393181 SGTC_1432 4049-0298 68.4 µM -0.72816519816504 0.250423096238234 no 2546 0.233256233432717 3722 741646 SGTC_3337 9144342 33.5465 µM -0.729621488683409 0.249997742809241 no 2547 0.232810791715397 3736 17682949 SGTC_3014 9081533 49.47 µM -0.730031934600037 0.249877929029008 no 2548 0.232685332325563 3722 21367265 SGTC_1523 st012844 44.7 µM -0.731178351100739 0.249543438683591 no 2549 0.232335110838755 3816 4274103 SGTC_2634 4'-methoxyflavone 100 µM -0.731696590338332 0.249392309953322 no 2550 0.232176889005056 3740 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2195 6536160 144.242 µM -0.731700908225572 0.24939105097707 no 2551 0.232175570977748 3655 3834386 SGTC_899 1083-0020 478 µM -0.732475900903147 0.249165139317427 no 2552 0.231939073316197 3757 767123 SGTC_1388 3346-4487 254 µM -0.733272406833824 0.24893306997389 no 2553 0.231696150499263 3783 3345614 SGTC_931 2812-0076 566 µM -0.733557353799941 0.248850075995828 no 2554 0.231609280229724 3751 3450959 SGTC_175 3793-3120 23.7 µM -0.734269913025934 0.248642599672439 no 2555 0.231392125556544 3737 5322297 SGTC_533 1222-0222 6.71 µM -0.734474605280341 0.248583016338236 no 2556 0.231329765945202 3824 3982874 SGTC_2878 9043973 25.97 µM -0.735428458377432 0.248305462067551 no 2557 0.231039297704029 3795 6465167 SGTC_3020 9089140 49.47 µM -0.737286122032391 0.247765389581247 no 2558 0.23047418496507 3768 17217859 SGTC_1129 3453-1384 223 µM -0.738147702870452 0.247515118067082 no 2559 0.230212349262695 3861 1084452 SGTC_427 1354-0053 47.3 µM -0.740190517969443 0.246922262495959 no 2560 0.229592200129152 3823 6813657 SGTC_2520 obtusaquinone 4.71 µM -0.742503618476816 0.246251884562245 no 2561 0.228891130126525 3771 5967872 SGTC_68 0986-0284 82.829 µM -0.745054971331582 0.245513590088834 no 2562 0.228119244370538 3802 423278 YIL048W NEO1 SGTC_2819 7996655 46.38 µM -0.746036450301503 0.245229892913069 no 2563 0.227822698227371 3679 6456960 SGTC_1973 st070275 50.2 µM -0.74624423389344 0.24516985553658 no 2564 0.2277599458869 3668 17118334 SGTC_167 3672-0051 66.205 µM -0.746421058542906 0.245118769720223 no 2565 0.227706551062637 3693 3237971 SGTC_120 rhodamine 6G 52.259 µM -0.747511103126517 0.244803975058866 no 2566 0.227377551586415 3787 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2329 6138490 200 µM -0.747831008925405 0.244711630583089 no 2567 0.22728104782028 3828 720019 SGTC_1934 st074720 32.6 µM -0.748090728040666 0.244636673479846 no 2568 0.227202717132155 3714 17250992 SGTC_2151 5563267 85.4165 µM -0.748291439185397 0.244578755040031 no 2569 0.22714219353644 3784 5310824 SGTC_1253 0550-0034 176 µM -0.749277911795552 0.244294199833565 no 2570 0.226844859037452 3744 5969915 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.750527038355118 0.243934136385291 no 2571 0.226468672770713 3561 4000243 SGTC_2677 mitomycin C 100 µM -0.751560038348499 0.24363658833528 no 2572 0.226157841349302 3762 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2524 avocatin b 10.57 µM -0.751896007828209 0.243539857051254 no 2573 0.226056799550976 3727 6710748 SGTC_2970 9090938 41.86 µM -0.752362785640384 0.243405498278509 no 2574 0.22591645990662 3749 17217104 SGTC_3236 9132701 49.47 µM -0.752661329264804 0.243319585560418 no 2575 0.225826726750475 3770 24282524 SGTC_659 k018-0002 107 µM -0.753293001990085 0.243137861401509 no 2576 0.225636931554685 3726 6797879 YHR007C ERG11 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.753331245378043 0.243126861624742 no 2577 0.225625443674641 3796 6708784 An antioxidant flavonoid SGTC_2188 6126565 140.678 µM -0.753991852579366 0.242936896569893 no 2578 0.225427057004101 3705 874518 SGTC_1722 st034304 3.6505 µM -0.754528130370094 0.242782742912677 no 2579 0.225266080295513 3787 4036148 YLR033W RSC58 SGTC_2024 5144227 134 µM -0.754867331165516 0.242685266600515 no 2580 0.225164294620095 3810 3475211 SGTC_2123 5259487 200 µM -0.755083680034665 0.24262310537972 no 2581 0.225099387346025 3743 2173474 SGTC_1369 1866-0067 208 µM -0.755368809162519 0.242541195428086 no 2582 0.225013861358029 3765 3531355 SGTC_1248 0469-0687 58.6 µM -0.755838265530388 0.242406365838775 no 2583 0.224873085569682 3770 4017482 SGTC_2245 6637752 200 µM -0.756224629568931 0.242295431140791 no 2584 0.224757264126841 3803 681890 SGTC_2849 9019321 12.99 µM -0.756397482356223 0.242245809727883 no 2585 0.22470545851131 3759 16489627 SGTC_2934 9036370 36.88 µM -0.757911899271138 0.241811296754784 no 2586 0.224251863124439 3783 6462800 SGTC_1647 st011722 22.4 µM -0.758351888865305 0.241685135298859 no 2587 0.224120175773982 3738 2854783 SGTC_358 0075-0058 9.45 µM -0.758754271163335 0.241569788547247 no 2588 0.223999782616084 3717 1069125 SGTC_1685 st024049 53.0905 µM -0.759671248973702 0.241307039764852 no 2589 0.223725559321478 3783 1941139 SGTC_2004 4023728 41.89 µM -0.760797433702166 0.240984557888002 no 2590 0.22338903373943 3765 360084 YDR527W RBA50 SGTC_2444 5485484 36.41 µM -0.761259739702904 0.240852244911406 no 2591 0.223250971275593 3859 6790631 SGTC_1772 st048439 82.2 µM -0.763127236997078 0.240318165663504 no 2592 0.222693758919403 3799 2927068 YDL195W SEC31 SGTC_2022 5136654 200 µM -0.765287635882331 0.239701126302424 no 2593 0.222050142429805 3814 1713771 SGTC_1526 st051518 75 µM -0.765403041141887 0.239668189331029 no 2594 0.222015791308806 3778 673993 SGTC_1919 st067113 52.3 µM -0.765446286774358 0.23965584754748 no 2595 0.222002919748456 3824 1268243 SGTC_769 0302-0231 76 µM -0.765618581276934 0.239606680212049 no 2596 0.221951642520741 3754 571869 YER009W NTF2 SGTC_511 blebbistatin 171 µM -0.767427499757543 0.239090805299344 no 2597 0.221413691753169 3827 3476986 A myosin inhibitor. SGTC_1071 trifluoperazine 6.31 µM -0.768398744827093 0.238814072270117 no 2598 0.221125162928184 3871 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_205 1486-1330 71.903 µM -0.768911433263033 0.238668064657089 no 2599 0.220972944812682 3764 4118834 SGTC_2687 chenodiol 100 µM -0.770950685249959 0.23808779361808 no 2600 0.220368081305414 3811 5702181 A cholesterol synthesis inhibitor. SGTC_2168 5727979 200 µM -0.772791710096115 0.237564593101896 no 2601 0.219822830155544 3732 695210 SGTC_1514 1189-1591 158 µM -0.773719816321794 0.237301074179415 no 2602 0.219548249400232 3797 767698 YMR146C TIF34 SGTC_29 0299-0004 12.984 µM -0.774815943140671 0.236990055723371 no 2603 0.219224213522494 3685 16871 A napthoquinone isolated from Swertia calycina. SGTC_1471 k673-0312 37 µM -0.777840721337643 0.236132959033005 no 2604 0.218331459118012 3782 24099884 SGTC_1459 k035-0031 35.7 µM -0.778323051087312 0.23599644481307 no 2605 0.218189294771207 3662 3877128 YMR208W ERG12 SGTC_3215 9129942 49.47 µM -0.781181292846478 0.23518836724815 no 2606 0.217347937359603 3745 17682944 SGTC_2387 9077560 195.08 µM -0.781496429534552 0.235099365921188 no 2607 0.217255287935926 3791 5303272 SGTC_1280 0880-0253 10.1 µM -0.78166487440347 0.235051801125449 no 2608 0.217205774908395 3790 6836607 SGTC_404 fumagillin 50 µM -0.783356205391836 0.234574504557654 no 2609 0.216708983064556 3796 12015870 A methionine aminopeptidase binder. SGTC_1739 st037196 92.5 µM -0.783837961427519 0.234438650318826 no 2610 0.216567598002548 3824 612214 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.785030586916905 0.234102519674937 no 2611 0.216217817672794 3835 5377381 SGTC_2796 7949634 45.45 µM -0.785119575377354 0.23407744979135 no 2612 0.216191731726097 3784 2971588 SGTC_3331 9141060 1.957 µM -0.786068708702537 0.233810151890574 no 2613 0.215913617572642 3795 4906567 YPR165W RHO1 SGTC_2913 7966556 36.57 µM -0.786214186933217 0.233769196811792 no 2614 0.21587100800858 3698 2976516 SGTC_1837 st055472 66.5 µM -0.788102702016411 0.233237902421663 no 2615 0.215318317419842 3908 676091 SGTC_478 N-arachidonylglycine 10 µM -0.792022640108297 0.232137251749386 no 2616 0.214173737628852 3757 5283389 SGTC_2900 5328528 85.29 µM -0.794923737550056 0.231324538915304 no 2617 0.213328932605794 3841 795359 SGTC_1755 st041960 45.185 µM -0.79523757357785 0.231236716180909 no 2618 0.21323765956286 3873 2257073 SGTC_1267 0828-0272 9.49 µM -0.797093670573 0.230717693231075 no 2619 0.212698316020551 3865 745334 SGTC_3098 9119039 49.47 µM -0.797136871055223 0.230705620775652 no 2620 0.212685772343135 3824 17161528 SGTC_2324 6149169 200 µM -0.798141293294271 0.230425032610485 no 2621 0.212394250432685 3767 2888231 SGTC_2 0422-0095 29 µM -0.798217139999339 0.230403852370733 no 2622 0.212372246290857 3689 6790840 SGTC_1139 k015-0024 46.9 µM -0.798507109071372 0.230322888361897 no 2623 0.212288134673597 3806 2766652 SGTC_522 1273-0010 11.6 µM -0.798607267588334 0.230294926197006 no 2624 0.212259086117567 3938 5705015 SGTC_326 k292-0812 17.5 µM -0.800260387348502 0.229833684046448 no 2625 0.211779974425013 3784 3579357 SGTC_1880 MG-132 525 µM -0.802055276754235 0.229333472480617 no 2626 0.211260491901286 3757 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_731 3966-0296 387 µM -0.802378164426512 0.229243552837026 no 2627 0.211167120030483 3853 660956 SGTC_2882 9058044 58.44 µM -0.803476152054064 0.228937926794139 no 2628 0.210849787634569 3813 18076804 SGTC_357 1325-0123 420 µM -0.804045587039613 0.228779514033282 no 2629 0.210685323863367 3858 1098503 SGTC_862 0452-0056 10.2 µM -0.804061687810682 0.228775035808065 no 2630 0.21068067474546 3790 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.804197230422432 0.228737338301061 no 2631 0.210641539031847 3830 6708760 SGTC_1621 st003705 32.4 µM -0.805000960974188 0.228513874080745 no 2632 0.210409562622353 3883 24207032 SGTC_2701 st077767 14.721 µM -0.805468227080968 0.228384014727586 no 2633 0.21027476709675 3837 5721188 SGTC_1284 0929-0043 16 µM -0.805619472740625 0.228341990469076 no 2634 0.21023114706802 3821 1239883 SGTC_2922 7999257 32.47 µM -0.805923844880594 0.228257432532224 no 2635 0.210143380682037 3808 2988377 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.806893345713845 0.227988211867019 no 2636 0.209863966452074 3786 5355888 SGTC_2186 6124449 200 µM -0.807151719451535 0.227916494224441 no 2637 0.209789538921038 3814 3834182 YLR033W RSC58 SGTC_3353 9151644 39.2805 µM -0.807177367866966 0.227909375602545 no 2638 0.209782151446326 3915 4909158 SGTC_1056 3448-1962 115 µM -0.809083505333048 0.227380684490336 no 2639 0.20923355767898 3846 715507 SGTC_1371 2421-0008 32.7 µM -0.80935835830719 0.227304507610857 no 2640 0.209154523648706 3846 2827552 SGTC_319 1348-1596 45.5 µM -0.811300046907082 0.226766768692406 no 2641 0.208596691565835 3930 5380505 SGTC_2723 salbutamol 83.58 µM -0.812274129148339 0.226497273102999 no 2642 0.208317175980687 3819 9884233 β2-adrenoceptor agonist SGTC_1757 st041620 31.8375 µM -0.813917551852195 0.226043003833016 no 2643 0.207846092478032 3931 5289815 SGTC_1251 0490-5699 265 µM -0.815065396348911 0.225726026298507 no 2644 0.207517438854713 3868 3883818 SGTC_1829 berberine 14.4 µM -0.815426090908125 0.225626472355738 no 2645 0.207414227367448 3884 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1636 st007707 68.9 µM -0.815442091978577 0.225622056536324 no 2646 0.207409649420142 3857 403051 SGTC_233 rapamycin 362 pM -0.815809679626192 0.225520626747999 no 2647 0.207304498099755 3857 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_408 cantharidin 100 µM -0.816785917955031 0.225251375102193 no 2648 0.207025390560929 3830 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3067 9117431 49.47 µM -0.817026231155932 0.22518512339856 no 2649 0.206956718888632 3898 17150885 SGTC_1995 st072814 61.1 µM -0.817092645599393 0.225166815614752 no 2650 0.206937742738041 3842 5769371 SGTC_603 3794-0023 45.9 µM -0.818896250970759 0.224669956827994 no 2651 0.206422804540899 3834 3802260 SGTC_1132 3456-3614 2.5 µM -0.819327633669966 0.224551211365023 no 2652 0.206299755263237 3959 3125502 SGTC_2727 riluzole 51.77 µM -0.820259203219729 0.224294902433599 no 2653 0.206034179095945 3862 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3265 9137266 49.47 µM -0.822375234102766 0.22371332231587 no 2654 0.205431685035506 3757 17224265 SGTC_1681 tripelennamine 100 µM -0.822439736948676 0.223695607519113 no 2655 0.205413335692395 3827 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_551 k048-0028 34.9 µM -0.824667923929671 0.223084157223201 no 2656 0.204780073548881 3844 6836383 SGTC_727 3032-0951 202 µM -0.825560514578989 0.222839483249188 no 2657 0.204526720796667 3874 3652836 SGTC_1652 st011932 78 µM -0.826404075177462 0.222608389825949 no 2658 0.204287456251638 3786 1551076 SGTC_2116 5511452 16.8835 µM -0.828104450497637 0.222142987513478 no 2659 0.203805674649713 3933 870744 SGTC_2921 7974240 10.71 µM -0.828517040568659 0.222030143065881 no 2660 0.20368887423104 3948 2979074 YDR527W RBA50 SGTC_211 3455-0679 143.504 µM -0.828524225490272 0.222028178261258 no 2661 0.203686840600057 3916 748649 SGTC_2841 9004761 38.96 µM -0.830331851788412 0.221534176250941 no 2662 0.203175592078899 3892 2991039 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.830652693423075 0.221446559881731 no 2663 0.203084928981542 3903 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_497 capsazepine 133 µM -0.830761370622626 0.221416886487597 no 2664 0.203054224568348 3862 2733484 A calcium channel blocker. SGTC_1367 1812-0510 76.9 µM -0.833902694552059 0.22056015757336 no 2665 0.202167909355664 3928 1142582 YDR527W RBA50 SGTC_1173 0443-0020 122 µM -0.834211898435869 0.220475931628342 no 2666 0.202080793704803 3874 5331295 SGTC_2799 7812892 81.82 µM -0.835384821577457 0.220156599517867 no 2667 0.201750536545352 3900 20205235 SGTC_3277 9138724 49.47 µM -0.836245991294319 0.219922312255448 no 2668 0.20150826495728 3818 15943418 SGTC_2933 9026794 32.47 µM -0.837354637147379 0.219620908136309 no 2669 0.201196628076655 3888 17586027 SGTC_3170 9103054 49.47 µM -0.838958109495703 0.219185397012512 no 2670 0.200746408615082 3912 16432970 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.838968234933317 0.219182648471328 no 2671 0.200743567539525 3795 1241132 A phosphatase inhibitor. SGTC_2202 7226349 200 µM -0.839049128981351 0.219160690564243 no 2672 0.20072087051286 3841 844334 SGTC_816 0325-0417 81.3 µM -0.839405793158711 0.21906389260402 no 2673 0.200620817041276 3920 68101 SGTC_2117 5521686 200 µM -0.840320142559048 0.218815852298843 no 2674 0.200364455343657 3845 803312 SGTC_413 propylparaben 100 µM -0.840404779490873 0.218792900573766 no 2675 0.200340735128341 3851 7175 A pharmaceutical preservative. SGTC_1235 benzylparaben 21.5 µM -0.840559370664377 0.218750982331196 no 2676 0.200297414000829 3901 7180 SGTC_704 1310-0270 142 µM -0.841865192294392 0.218397086103546 no 2677 0.199931707859652 3888 5718033 SGTC_1381 2324-0066 62.1 µM -0.8422434567701 0.218294632684967 no 2678 0.199825846813957 3952 10885928 SGTC_199 4063-0024 41.6 µM -0.842372746377117 0.218259620779668 no 2679 0.199789671574159 3904 306215 SGTC_780 0109-0199 192 µM -0.844372387320238 0.217718525835221 no 2680 0.199230673688703 3974 610414 SGTC_593 1203-0218 61.7 µM -0.844788159880501 0.217606116687457 no 2681 0.199114563234895 3933 3666956 SGTC_2149 5554786 194.827 µM -0.845090159922199 0.217524488321458 no 2682 0.19903025095451 3928 745063 YPR165W RHO1 SGTC_1644 st010134 20.9 µM -0.849048197887921 0.216456295007898 no 2683 0.19792723674282 3867 3818134 SGTC_95 0471-0001 561.058 µM -0.851035680245495 0.215921061112895 no 2684 0.197374766406604 3883 4015405 SGTC_2369 9071472 200 µM -0.852022500723491 0.2156555930881 no 2685 0.197100801862747 3989 17296037 SGTC_3089 9117425 49.47 µM -0.85242087504728 0.215548478659075 no 2686 0.196990269026475 3881 9401657 SGTC_1711 st032263 62.8 µM -0.852544416876137 0.215515267143497 no 2687 0.196955998766234 3906 3958979 SGTC_279 1273-0055 2.93 µM -0.852918467282286 0.215414729980644 no 2688 0.196852259927673 3913 2847562 SGTC_2075 5212009 200 µM -0.853132535032006 0.215357205154506 no 2689 0.196792905437985 3779 780898 SGTC_2583 asiatic acid 100 µM -0.853345055252418 0.215300105001841 no 2690 0.196733990752762 3894 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1956 st077085 54 µM -0.859885107291753 0.21354721666102 no 2691 0.194926189343097 3960 24208685 SGTC_2420 aureobasidin a 50 nM -0.862156589034489 0.21294035714456 no 2692 0.194300677284323 4066 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1084 voriconazole 435 nM -0.862302185225528 0.212901493347137 no 2693 0.194260625281372 3905 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_549 1661-1316 519 µM -0.863301155616966 0.212634951171778 no 2694 0.193985954496406 3914 2857282 SGTC_3298 9116858 71.43 µM -0.863716133296904 0.212524285430961 no 2695 0.193871924377897 3982 2506942 SGTC_873 0591-4978 488 µM -0.863893273944894 0.212477056027032 no 2696 0.19382326102586 3995 3305145 SGTC_1229 0139-0193 12.2 µM -0.864919665833472 0.212203519186568 no 2697 0.193541441441735 3963 3090752 SGTC_1356 1502-0781 85.8 µM -0.866449610235842 0.211796166278176 no 2698 0.193121824114006 3880 567702 SGTC_762 1165-0429 115 µM -0.868494815431409 0.211252338698467 no 2699 0.192561754656547 3894 5967793 SGTC_69 0096-0274 206.684 µM -0.868862466782942 0.211154665676909 no 2700 0.192461180508253 4072 6741392 SGTC_842 0271-0008 11.1 µM -0.869121888118689 0.211085761782662 no 2701 0.192390232929087 3980 1221709 SGTC_2792 7535235 81.82 µM -0.86941894662295 0.211006877413572 no 2702 0.192309011831161 3936 1281891 SGTC_1375 2910-0797 186 µM -0.871083753068364 0.210565105279776 no 2703 0.191854212232478 3949 742508 SGTC_371 0195-0006 7.36 µM -0.87144008811654 0.21047061897305 no 2704 0.191756952579868 3778 3928593 SGTC_2180 6301957 200 µM -0.871673652534841 0.210408700204863 no 2705 0.19169321886505 3915 845462 SGTC_234 nsc-17383 10.7 µM -0.872172726372503 0.210276429776524 no 2706 0.191557077949069 3923 408974 SGTC_3185 9108267 49.47 µM -0.872262336618032 0.21025268538523 no 2707 0.19153263970179 3916 4910486 SGTC_2377 9073351 62.6 µM -0.872446974420591 0.210203766120407 no 2708 0.191482291836241 3904 7337946 YHR072W ERG7 SGTC_1333 1482-0047 286 µM -0.874971078040309 0.209535682608718 no 2709 0.190794821315768 3915 3811116 SGTC_476 mead acid 10 µM -0.876032198240472 0.209255197066786 no 2710 0.190506264985723 3944 5312531 An omega 9 fatty acid. SGTC_2423 st077119 87.2 µM -0.876561693090578 0.209115318568221 no 2711 0.190362376767666 3863 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1374 2889-5571 141 µM -0.876987530183659 0.209002863654848 no 2712 0.190246705592631 3970 2853281 SGTC_1509 1326-1131 80 µM -0.877500623881089 0.208867413371352 no 2713 0.19010739006362 3835 768313 SGTC_1626 st003712 1.76 µM -0.878109442379012 0.208706760054044 no 2714 0.189942164628396 3949 24207035 SGTC_2073 5212005 126 µM -0.880850976281439 0.207984234678025 no 2715 0.189199242273051 3745 691789 SGTC_683 panaxydol 45 µM -0.881113317306126 0.207915172764552 no 2716 0.189128244964187 3931 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2221 6807166 181.081 µM -0.883225812958171 0.207359546847854 no 2717 0.188557138779089 3876 674925 SGTC_3292 9120825 59.784 µM -0.885229207414637 0.2068334285023 no 2718 0.188016511261472 3924 24824900 SGTC_3313 9133968 57.047 µM -0.886523330859606 0.206493994740979 no 2719 0.187667793831454 3904 1494643 SGTC_2774 tamoxifen 10.92 µM -0.887145559911358 0.206330908732213 no 2720 0.187500268918887 3968 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_416 estradiol valerate 100 µM -0.887577894836202 0.206217638862903 no 2721 0.187383924301737 3973 13791 A steroid. SGTC_2976 9009005 19.48 µM -0.88780747434366 0.206157505017779 no 2722 0.187322160854401 3972 2993148 SGTC_2989 9073649 71.4286 µM -0.887848648834851 0.206146721267666 no 2723 0.187311085070971 3859 21367202 SGTC_916 4466-0038 42 nM -0.889897970559924 0.205610419066595 no 2724 0.18676033687985 4032 5722064 YGL116W CDC20 SGTC_1955 wogonin 32.4 µM -0.892689678314579 0.204881170508739 no 2725 0.186011689679264 4044 5281703 A flavanone. SGTC_598 3937-0236 20.2 µM -0.894981096420776 0.204283758182459 no 2726 0.185398596617421 4028 1379313 SGTC_1343 1487-0095 224 µM -0.89552033561998 0.204143320111145 no 2727 0.185254500033287 3970 4560101 YGL055W OLE1 SGTC_3297 9117502 71.43 µM -0.897003825306415 0.203757260694415 no 2728 0.184858437909246 3966 7453720 SGTC_1422 4031-0024 15.5 µM -0.898673299805099 0.203323321995209 no 2729 0.184413351435408 3923 782427 SGTC_1260 0700-1617 7.75 µM -0.900126154149843 0.202946137515011 no 2730 0.18402655949391 3997 2853078 SGTC_1666 st014829 29 µM -0.901360556084328 0.202625995420928 no 2731 0.183698323111429 3964 3858230 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.902441577453322 0.202345880634221 no 2732 0.183411171518165 4019 5282362 SGTC_2296 7971656 126.45 µM -0.903051174465195 0.202188023729462 no 2733 0.183249367788271 4026 666570 SGTC_2780 5215298 71.43 µM -0.905648957333657 0.2015161467865 no 2734 0.182560843556858 4011 2834131 SGTC_2165 5727197 32.143 µM -0.905669361560392 0.201510874844881 no 2735 0.182555441961846 4159 1361712 SGTC_2193 5925765 200 µM -0.905686010457902 0.201506573247592 no 2736 0.18255103458616 3961 877370 SGTC_2212 7123476 200 µM -0.90657794988482 0.20127620213989 no 2737 0.182315013275265 3933 1085715 SGTC_2391 6285546 200 µM -0.906690711541519 0.201247089180386 no 2738 0.182285188336337 3962 846083 SGTC_1578 josamycin 24.2 µM -0.910528049739188 0.2002578654721 no 2739 0.181272047945308 3989 5282165 A P450 substrate. SGTC_2753 fluvastatin 17.09 µM -0.911907245312132 0.199903038987403 no 2740 0.180908773592086 4033 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1054 3429-0080 167 µM -0.913717838708654 0.199437800919851 no 2741 0.180432564041585 4033 1162877 SGTC_1241 0364-0022 50.8 µM -0.914848131693432 0.199147699080586 no 2742 0.180135681396533 4006 4563895 SGTC_1854 st056233 32.9 µM -0.915958048221173 0.19886307458644 no 2743 0.179844449413781 3880 5393174 SGTC_2898 9056270 58.44 µM -0.915971259506783 0.19885968819148 no 2744 0.179840984674874 3921 19154699 SGTC_2969 9091408 28.7 µM -0.915989087403799 0.19885511849445 no 2745 0.179836309268396 3946 4286311 SGTC_2664 lyso-paf C-16 73.48 µM -0.919333079074135 0.197999096917521 no 2746 0.178960690373615 3964 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1899 st063254 59.6 µM -0.920004300352536 0.197827540933384 no 2747 0.178785255993386 3935 3093813 SGTC_1802 st050112 57.9 µM -0.9233334185951 0.196977986982195 no 2748 0.177916738775873 3991 4662563 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.924689863184849 0.196632471581993 no 2749 0.177563626883367 4127 16725076 SGTC_1686 st019653 115.5 µM -0.924699352935248 0.196630055633924 no 2750 0.177561158054936 3956 97252 SGTC_2348 9022543 33.42 µM -0.925116749032492 0.196523810640275 no 2751 0.177452590819901 4049 3162678 YDL140C RPO21 SGTC_287 k060-0039 29.6 µM -0.928397268528686 0.195689991063311 no 2752 0.176600767445178 4055 5861974 SGTC_1498 4478-3555 97.6 µM -0.929137297912818 0.195502192853102 no 2753 0.176408968622497 3936 3437919 SGTC_3162 9099653 49.47 µM -0.929680213762744 0.195364486027289 no 2754 0.176268340991398 3990 25237511 SGTC_17 0960-0276 49.807 µM -0.930918093395033 0.195050726892617 no 2755 0.175947967196995 4004 6821114 SGTC_3285 9112818 20.8695 µM -0.930959602167787 0.195040211183313 no 2756 0.175937230766323 3980 17017947 YPR165W RHO1 SGTC_1043 0916-0009 19.3 µM -0.933739418875983 0.194336765287242 no 2757 0.17521916303923 4054 3101130 SGTC_3048 9093155 49.47 µM -0.938119211777593 0.193231576969756 no 2758 0.17409157489443 3969 25236002 SGTC_98 0074-0023 107.663 µM -0.942933066484065 0.192021293639207 no 2759 0.172857570108805 4042 3563821 SGTC_477 mead ethanolamide 10 µM -0.944005324500661 0.191752343176569 no 2760 0.172583463695723 3920 16061185 SGTC_280 3448-3607 3.04 µM -0.945051649146892 0.191490119968569 no 2761 0.17231625408845 4000 626179 SGTC_578 3460-0051 92 µM -0.945374796556532 0.191409179251601 no 2762 0.172233782319213 4108 2876744 SGTC_1726 st035556 14.5795 µM -0.945719769106243 0.191322794998531 no 2763 0.172145768267345 4139 5919439 SGTC_3049 9092223 49.47 µM -0.946848384362094 0.191040346513316 no 2764 0.17185802132909 4013 8623917 SGTC_686 1319-0111 510 µM -0.947449283294128 0.190890069268098 no 2765 0.171704944068886 4059 4562600 SGTC_3087 9117406 49.47 µM -0.949988647858352 0.190255807380754 no 2766 0.17105901043843 4064 42546093 SGTC_851 0394-0702 453 µM -0.95061307905437 0.190100040565273 no 2767 0.170900413382104 4040 762646 SGTC_3013 9080133 71.4286 µM -0.951097789660655 0.189979181645832 no 2768 0.170777368342731 4123 17050193 SGTC_2717 st081029 62.2815 µM -0.95158532281068 0.18985766660364 no 2769 0.17065366400124 4006 5292846 SGTC_2958 9077254 16.72 µM -0.953451389574663 0.189393001075943 no 2770 0.170180707224192 4114 16457351 SGTC_1175 0741-0056 27.6 µM -0.954000789532703 0.189256329584713 no 2771 0.170041621364787 4131 765927 SGTC_1924 st058459 75.1 µM -0.955088467092977 0.188985932612867 no 2772 0.169766480345911 4015 688683 SGTC_1190 1486-1332 13 µM -0.955494114031308 0.188885149619683 no 2773 0.16966394024889 4037 4150046 SGTC_1114 scopoletin 1.73284 µM -0.956671255619073 0.18859287629144 no 2774 0.169366605439797 4072 5280460 A coumarin with genotoxic properties. SGTC_971 1315-0384 26.7 µM -0.959265445260963 0.187949748138561 no 2775 0.168712519183188 4067 6769120 SGTC_2720 fluspirilene 36.88 µM -0.959371362248347 0.18792351895505 no 2776 0.168685848332986 4040 3396 An atypical antipsychotic. SGTC_3327 9140648 26.9345 µM -0.963112154533058 0.186998602603587 no 2777 0.167745621392436 4074 8029710 SGTC_1296 1068-0102 11.9 µM -0.964288399616972 0.186708357278057 no 2778 0.167450677582884 4056 767053 SGTC_2673 kobusone 100 µM -0.966935850620673 0.186056104276772 no 2779 0.16678805164836 4119 6710676 An epoxy ketone and protein crosslinker. SGTC_41 0478-0632 82.643 µM -0.967615749495447 0.185888825694939 no 2780 0.166618154320232 3959 3750424 SGTC_1312 1218-2183 165 µM -0.968252373855723 0.185732278716314 no 2781 0.166459171988925 4076 6744073 SGTC_928 2764-0428 58.7 µM -0.968633874484936 0.18563850628465 no 2782 0.166363947901965 4093 662578 SGTC_1414 3917-0015 5.4 µM -0.971184882259515 0.185012226601876 no 2783 0.165728110346111 4008 6618702 SGTC_455 paf C-16 10 µM -0.971217236803446 0.185004291908625 no 2784 0.165720056093792 4025 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_903 1134-0042 114 µM -0.971432994875646 0.18495138437248 no 2785 0.165666352336341 4074 701009 SGTC_2745 rifampicin 24.3 µM -0.971787584721859 0.184864453357404 no 2786 0.165578116785935 4062 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1552 6-methylflavone 10.6 µM -0.974940712429868 0.184092551932095 no 2787 0.164794834832837 3963 689013 SGTC_1421 4029-0249 71.4 µM -0.975327897916674 0.183997905498104 no 2788 0.164698818157078 4131 2894095 SGTC_3224 9130643 49.47 µM -0.975699980112327 0.18390697957594 no 2789 0.1646065810484 4110 17644395 SGTC_2125 5246583 200 µM -0.976149836924688 0.183797085204147 no 2790 0.164495108752781 4055 835267 SGTC_251 melphalan 456.522 µM -0.980082905608568 0.182838028860507 no 2791 0.163522598267916 4084 460612 A DNA alkylator. SGTC_1861 st057647 17.4 µM -0.980294757017808 0.182786458914457 no 2792 0.163470321005509 4149 688668 SGTC_3315 9136395 68.55 µM -0.98350834391694 0.182005305102403 no 2793 0.162678655366032 4069 16876844 SGTC_2378 9074213 121.43 µM -0.987565716549013 0.181022031516762 no 2794 0.161682691740594 4042 657714 SGTC_334 1502-1024 68.5 µM -0.987580071555872 0.181018558608739 no 2795 0.161679175085967 4102 3296216 SGTC_1477 0139-0234 16 µM -0.989361180589852 0.180587978720692 no 2796 0.16124323017842 4097 620880 SGTC_213 1246-0773 967 nM -0.989381876350241 0.180582979336135 no 2797 0.161238169187373 4072 6251622 SGTC_1207 2099-0101 141 µM -0.990035076199311 0.180425233302845 no 2798 0.161078487375011 4096 5837381 SGTC_2357 9067248 200 µM -0.991531854139877 0.180064091521791 no 2799 0.160712973015847 4075 9150235 SGTC_2997 9067075 71.4286 µM -0.996402283569179 0.178892100871125 no 2800 0.159527361961177 4107 27209819 SGTC_1061 3448-9325 110 µM -0.998016549243002 0.17850471546847 no 2801 0.159135666913583 3988 723482 SGTC_83 0170-0301 39.027 µM -1.00551008470039 0.176713372110637 no 2802 0.157325647966401 4076 3089716 SGTC_2076 5212012 200 µM -1.00581032349969 0.176641837085195 no 2803 0.157253410170383 4037 604802 SGTC_3004 9076122 71.4286 µM -1.00671988017207 0.17642523750179 no 2804 0.157034702927016 4126 44782551 SGTC_356 1634-0012 32.5 µM -1.00710594533199 0.176333351711794 no 2805 0.156941932230164 4120 735457 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.00722094124292 0.176305987859333 no 2806 0.156914305910299 4081 688662 SGTC_3134 9127454 49.47 µM -1.00876221173374 0.175939494210692 no 2807 0.156544343906261 4134 24262820 SGTC_2656 pseudo-anisatin 100 µM -1.01026641999356 0.175582278997715 no 2808 0.156183832405963 4133 6708809 A neurotoxin. SGTC_2954 9074818 52.69 µM -1.01078160926146 0.175460039016808 no 2809 0.156060483568456 4134 16648742 SGTC_756 0508-1999 28.3 µM -1.01251878016947 0.175048254766652 no 2810 0.155645035938411 4102 6753853 SGTC_2467 5474540 200 µM -1.01336897844224 0.174846944838046 no 2811 0.155441975552849 4058 5413519 SGTC_1073 triclabendazole 3.09 µM -1.01365156041991 0.174780067631121 no 2812 0.155374522716782 4162 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2872 9044037 25.97 µM -1.01463278274885 0.174547972945657 no 2813 0.155140453150089 4097 6465195 SGTC_3336 9143619 71.43 µM -1.01626420317939 0.174162516290554 no 2814 0.154751795066961 4137 45595730 SGTC_1732 st034308 51.822 µM -1.01676060916239 0.174045337594623 no 2815 0.154633662571525 3969 830119 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.01708042656046 0.173969869921939 no 2816 0.154557585418327 4130 5379071 SGTC_2407 paclitaxel 400 µM -1.0179968552079 0.17375373447021 no 2817 0.154339725291649 4226 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_668 1682-0499 62.6 µM -1.01839302293873 0.173660353048879 no 2818 0.1542456082921 4087 682214 SGTC_956 1185-0240 191 µM -1.02295093688927 0.172588296514476 no 2819 0.153165522030789 4097 1416193 SGTC_2767 sibutramine 71.45 µM -1.02334160410372 0.172496605331731 no 2820 0.153073179631004 4147 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1205 4161-2785 76 µM -1.02344781072891 0.172471683577111 no 2821 0.153048081846029 4191 3498106 SGTC_952 1185-0122 232 µM -1.02819551507697 0.171359964511674 no 2822 0.151928933847787 4060 678600 SGTC_154 3389-1638 511.116 µM -1.02837986108563 0.1713168907672 no 2823 0.151885588986518 4118 5238686 SGTC_923 1900-2434 73.3 µM -1.02860451212281 0.171264408826698 no 2824 0.151832778402245 4069 5910570 SGTC_2375 9072683 200 µM -1.0291161119235 0.17114492960185 no 2825 0.151712557923874 4187 16798029 SGTC_789 1309-1135 70.6 µM -1.02989239208407 0.170963738650088 no 2826 0.151530261247017 4104 3092424 SGTC_2231 micatex 6.853 µM -1.03089239141536 0.17073051051825 no 2827 0.15129564250104 4139 20737 An antifungal of unknown mechanism. SGTC_2462 5162487 171.77 µM -1.03198954555157 0.170474857536918 no 2828 0.151038507513153 4012 2259986 SGTC_182 3448-4371 550.524 µM -1.03252906656293 0.170349231203127 no 2829 0.150912169171409 3999 3491403 SGTC_84 0443-0269 128.823 µM -1.03514756318852 0.169740362352521 no 2830 0.150300001461457 4035 6150058 SGTC_2029 5175081 200 µM -1.03609122157418 0.16952127968531 no 2831 0.150079793599446 4087 1380876 SGTC_1996 st072960 66.8 µM -1.03627572472841 0.169478466072781 no 2832 0.150036763927141 4162 1719405 SGTC_209 4077-0173 175.592 µM -1.03831152159932 0.169006523920161 no 2833 0.149562523201124 4107 15993494 SGTC_934 2950-0684 338 µM -1.03999183724883 0.168617626587284 no 2834 0.149171846521677 4185 1121253 SGTC_1814 st052110 31.539 µM -1.04178407078773 0.168203461140719 no 2835 0.148755900490274 4090 674163 SGTC_987 1497-1013 404 µM -1.04291982225161 0.167941340548122 no 2836 0.148492714103853 4126 1676435 SGTC_1294 1000-1494 117 µM -1.04495124216221 0.167473164317748 no 2837 0.148022752463355 4131 712797 YDL207W GLE1 SGTC_3338 9144300 39.5675 µM -1.04592245369995 0.167249629045109 no 2838 0.147798418316122 4140 4901274 SGTC_616 4092-0450 108 µM -1.04597393139291 0.167237786243739 no 2839 0.14778653415847 4143 787165 SGTC_2702 st077768 96.8 µM -1.04624882090015 0.167174555150679 no 2840 0.147723083905153 4134 6484119 SGTC_2864 9034755 47.6 µM -1.04781210006025 0.166815257040415 no 2841 0.147362593261064 4079 4930451 SGTC_1157 4092-0394 27.6 µM -1.05366926519603 0.165473502381802 no 2842 0.146017182525841 4242 3659885 SGTC_340 k038-0059 454 µM -1.05543967377286 0.165069316440807 no 2843 0.145612143043274 4124 23733424 SGTC_2886 9058944 51.95 µM -1.05648987175082 0.164829857539111 no 2844 0.145372232852732 4005 4949929 SGTC_296 1222-0039 74.9 µM -1.05684698261565 0.164748482869934 no 2845 0.145290714053079 4155 5984176 SGTC_910 3454-3003 490 µM -1.0585584397402 0.164358855324169 no 2846 0.144900461393304 4093 820824 SGTC_112 phenothiazine 287.218 µM -1.05860201564391 0.164348942710079 no 2847 0.144890534279833 4104 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2719 novobiocin 32.65 µM -1.06125423852509 0.163746346789557 no 2848 0.144287188131237 4181 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1261 0712-0010 12.7 µM -1.06125951454811 0.163745149486613 no 2849 0.144285989595028 4189 2840123 SGTC_2104 5389443 200 µM -1.06126426589327 0.163744071255176 no 2850 0.144284910253848 4198 2244536 SGTC_926 2268-1401 59.4 µM -1.06438911412512 0.163035942012375 no 2851 0.143576231569527 4128 2931578 SGTC_3097 9117246 49.47 µM -1.0660595303469 0.162658222745605 no 2852 0.143198366125877 4172 16423892 SGTC_742 0kpi-0133 140 µM -1.06635269384278 0.162591990550032 no 2853 0.143132118860256 4189 2728852 SGTC_1674 st016616 23.6 µM -1.06955967237877 0.161868608319259 no 2854 0.142408777807876 4108 625830 SGTC_3234 9132280 49.47 µM -1.07139263002185 0.161456100356657 no 2855 0.141996462638271 4198 17612295 SGTC_2661 dactinomycin 12.96 µM -1.07167850697461 0.161391825463678 no 2856 0.141932228892146 4131 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2360 9040895 200 µM -1.07688796732887 0.160223484177863 no 2857 0.140765159660765 4192 4914414 SGTC_2014 4013930 200 µM -1.07739527570891 0.160110004749287 no 2858 0.140651856904434 4140 64556 SGTC_3047 9092122 49.47 µM -1.07910929693472 0.159726985430218 no 2859 0.140269503633951 4150 17173831 SGTC_2333 9017922 200 µM -1.08354511138811 0.158738533339765 no 2860 0.139283269421404 4217 3163164 SGTC_1702 st027038 51 µM -1.08485793128991 0.158446762573038 no 2861 0.138992291407874 4210 5521182 SGTC_2397 5161689 200 µM -1.08726940667856 0.157911735648173 no 2862 0.138458882454342 4256 2259942 SGTC_2516 gossypol 71.55 µM -1.08865584259235 0.157604668913226 no 2863 0.138152840625669 4212 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1392 3455-1037 33.9 µM -1.09049933973917 0.157196980656572 no 2864 0.137746622000751 4187 981132 SGTC_546 peri-Naphthalide 147 µM -1.09130908832056 0.157018124648332 no 2865 0.137568450018538 4118 223824 A penicillin ester. SGTC_261 5-fluorouridine 15.376 µM -1.09324759056779 0.156590495293305 no 2866 0.137142553489158 4222 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3233 9132340 49.47 µM -1.09587786793331 0.156011488942064 no 2867 0.136566112876071 4183 17682950 SGTC_6 0844-0013 19.835 µM -1.09621927390165 0.155936438399251 no 2868 0.136491413441331 4325 1584900 SGTC_316 k060-0003 58.6 µM -1.09849523693337 0.155436726559502 no 2869 0.135994148189155 4230 6152314 SGTC_105 0111-0055 734.78 µM -1.10054200316777 0.154988240656301 no 2870 0.13554801957394 4200 5179370 SGTC_964 1287-0107 19.4 µM -1.10307295638874 0.154434842924967 no 2871 0.134997741939584 4217 51516812 YPR165W RHO1 SGTC_320 4092-0846 5.34 µM -1.1065920121351 0.153667568143834 no 2872 0.134235181210324 4149 1359356 SGTC_505 gw-5074 63.9 µM -1.10707407744771 0.153562658270306 no 2873 0.134130951065765 4223 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.10757061036604 0.153454649469605 no 2874 0.134023650935408 4193 5357218 A potent inhibitor of glutathione S-transferases. SGTC_338 4055-0136 114 µM -1.10857503353402 0.153236315234269 no 2875 0.133806776731382 4179 2900563 SGTC_2273 7815444 169.05 µM -1.10940036481916 0.153057064832437 no 2876 0.133628752534545 4162 2824616 SGTC_1346 1488-2224 62.4 µM -1.10996291127387 0.152934967302914 no 2877 0.133507504475992 4213 3722427 SGTC_2763 lisinopril 49.32 µM -1.11122671907669 0.152660900530171 no 2878 0.133235386537696 4080 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1479 0549-0158 134 µM -1.11177968900246 0.15254108713209 no 2879 0.133116443417207 4254 5440202 SGTC_2010 4012422 159 µM -1.11429558817337 0.151996748788156 no 2880 0.132576199530743 4172 952393 SGTC_2759 disulfiram 3.38 µM -1.11436394370674 0.151981977454338 no 2881 0.132561542522939 4111 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1455 4262-0120 131 µM -1.11522427672789 0.151796144752487 no 2882 0.132377162666202 4270 1529587 SGTC_2680 butyl paraben 22.24 µM -1.11720155757226 0.151369622805049 no 2883 0.131954077398356 4294 7184 An antifungal and steroid mimetic. SGTC_314 1671-0008 2.74 µM -1.11721420078222 0.151366898087909 no 2884 0.131951375093517 4089 3913060 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.11771327423736 0.15125936965318 no 2885 0.131844735788723 4192 688803 SGTC_2460 5552655 174.22 µM -1.11987199893554 0.150794844510392 no 2886 0.131384156075291 4243 5401989 SGTC_1313 1220-0047 237 µM -1.12407666272409 0.149892793210094 no 2887 0.130490252356758 4182 3528706 SGTC_153 4077-0274 519.67 µM -1.12494936449646 0.14970601927122 no 2888 0.130305245923032 4253 3121976 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.12667162362234 0.149337880456525 no 2889 0.12994067211619 4252 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2447 5741742 33.78 µM -1.13067886126671 0.148483660512441 no 2890 0.129095140835112 4268 1776504 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.13167218013696 0.148272421803751 no 2891 0.128886140850247 4254 688664 SGTC_2502 avocadyne acetate 18.59 µM -1.13240102912848 0.14811755306842 no 2892 0.128732936201406 4164 3952079 SGTC_2037 5169046 200 µM -1.13301064101105 0.147988103469098 no 2893 0.12860489236037 4280 5718022 SGTC_1703 st026983 48.3 µM -1.13417350337796 0.147741382532863 no 2894 0.12836088807402 4244 1104023 SGTC_127 0180-0333 59.125 µM -1.13458078201431 0.147655036643437 no 2895 0.128275504539393 4132 771601 SGTC_1633 st005664 67.9 µM -1.13459328614146 0.147652386216836 no 2896 0.128272883747925 4225 2063822 SGTC_1091 telmisartan 47.6 µM -1.13598771213102 0.147357017813774 no 2897 0.12798085350632 4256 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_67 0335-0847 266 µM -1.1373327444897 0.147072487434622 no 2898 0.127699605574001 4331 4552207 YOR254C SEC63 SGTC_1266 0828-0227 32.9 µM -1.13766558434236 0.147002134835545 no 2899 0.127630074709676 4222 3913820 SGTC_3039 9090270 49.47 µM -1.14162595765323 0.146166759826708 no 2900 0.126804764777945 4237 17173750 SGTC_2388 9080168 200 µM -1.14196739380316 0.146094889132918 no 2901 0.126733786610002 4236 15943073 SGTC_2275 7947463 200 µM -1.14259997681194 0.145961796147141 no 2902 0.126602357592608 4202 1225414 SGTC_1786 berberine 21.6 µM -1.14278054305 0.145923820669613 no 2903 0.126564859553827 4150 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_486 niguldipine 82 µM -1.14590460643595 0.145267839790685 no 2904 0.125917312520533 4293 1236 A calcium channel blocker. SGTC_2475 5812728 15.03 µM -1.14679931435128 0.145080337913354 no 2905 0.12573228633062 4162 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.14972109993968 0.144469160955609 no 2906 0.125129380485971 4299 1273210 SGTC_331 k048-0133 24.5 µM -1.15168837943063 0.144058625593077 no 2907 0.124724574575695 4196 6813582 SGTC_2028 5153890 36.43 µM -1.15230032783366 0.143931083694623 no 2908 0.124598841156286 4232 2830968 YPR165W RHO1 SGTC_2871 9038510 12.99 µM -1.15315059914897 0.143753997157051 no 2909 0.124424288059899 4219 4945164 SGTC_116 0155-0182 31.788 µM -1.15318263332613 0.143747328253926 no 2910 0.124417715073938 4130 771486 SGTC_366 0181-0206 4.31 µM -1.15391308295015 0.143595319258857 no 2911 0.124267902439211 4263 274874 SGTC_2132 5317594 122.667 µM -1.15540320756892 0.1432855559001 no 2912 0.123962674507797 4199 794577 SGTC_1300 1094-0077 113 µM -1.15708682947469 0.14293611216819 no 2913 0.123618443528589 4219 5532636 SGTC_1041 0206-0046 107 µM -1.16069253903671 0.142189668846445 no 2914 0.122883478542561 4249 50494 SGTC_1385 3091-4834 14.1 µM -1.16167930147168 0.141985852781322 no 2915 0.122682878231407 4223 4072814 SGTC_1583 clindamycin 39.6 µM -1.16216399078177 0.141885812534634 no 2916 0.12258442923587 4218 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_779 1360-0071 233 µM -1.16232582839921 0.14185241975707 no 2917 0.122551569491826 4299 7566 SGTC_2746 daunorubicin 9.88 µM -1.16245612488899 0.141825538887966 no 2918 0.122525118395141 4214 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1833 st055984 71 µM -1.16327064431025 0.141657577321603 no 2919 0.122359856059705 4250 676288 SGTC_3347 9188721 44.724 µM -1.16350578626698 0.141609113913264 no 2920 0.122312175927245 4277 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2764 methyldopa 94.69 µM -1.16384963854708 0.14153826523095 no 2921 0.122242475900173 4257 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2446 5162541 200 µM -1.16403418313717 0.141500250840125 no 2922 0.122205079584191 4215 1549321 SGTC_3007 9078383 71.4286 µM -1.16772456085407 0.140741521279622 no 2923 0.121458943195808 4236 6496995 SGTC_1020 4335-0961 93.3 µM -1.16837799228981 0.140607466138103 no 2924 0.121327164075507 4217 669075 SGTC_720 r052-1644 49.9 µM -1.16901102618967 0.14047767834211 no 2925 0.121199594485467 4277 1422863 YOR257W CDC31 SGTC_1513 0337-0559 19 µM -1.17007078317365 0.140260583735053 no 2926 0.120986242477635 4240 775073 SGTC_2540 epiandrosterone 100 µM -1.17254365159267 0.139754895320275 no 2927 0.120489428670735 4293 441302 A steroid. SGTC_252 miconazole 1.30953 nM -1.17567468245491 0.139116396370877 no 2928 0.11986244968052 4165 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1395 3486-0190 4.35 µM -1.17568018788174 0.139115275422086 no 2929 0.119861349265883 4250 6748079 SGTC_2079 5212404 121 µM -1.17790232262067 0.13866333303299 no 2930 0.1194177745201 4230 758462 SGTC_1507 4075-3230 155 µM -1.1782367868233 0.138595395705127 no 2931 0.119351110366111 4202 659771 SGTC_1465 k213-0056 144 µM -1.18063392729191 0.138109145400236 no 2932 0.118874089843527 4159 24048857 YMR208W ERG12 SGTC_821 1114-0266 29.2 µM -1.18152221391971 0.1379292557974 no 2933 0.11869766706851 4274 3123235 SGTC_879 0831-1030 162 µM -1.18191487229504 0.137849788330605 no 2934 0.118619740101192 4279 1549252 SGTC_2162 5663267 200 µM -1.18255188344695 0.137720934416152 no 2935 0.118493395796649 4265 6456493 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.18325321048839 0.137579165842245 no 2936 0.118354405159673 4309 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1941 st076221 61.8 µM -1.183817356548 0.137465199803697 no 2937 0.118242685043899 4150 2828568 SGTC_1 0258-0098 57.368 µM -1.18923054961909 0.136374929323053 no 2938 0.117174478030699 4227 6790032 YDR047W HEM12 SGTC_1467 k284-1082 293 µM -1.1896925263145 0.136282157400356 no 2939 0.117083631960107 4246 3334705 SGTC_441 propafenone 146 µM -1.1910596206501 0.13600787714475 no 2940 0.116815090116299 4262 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1483 3453-0561 55.9 µM -1.19264586834584 0.135690102051694 no 2941 0.116504046982957 4311 4546991 SGTC_935 2996-0153 430 µM -1.19282090962946 0.13565506698313 no 2942 0.11646975962028 4276 23738523 SGTC_1480 1070-0044 41.2 µM -1.19317888741796 0.135583435889287 no 2943 0.116399660655141 4303 3124987 SGTC_25 0118-0223 35.662 µM -1.1952127922507 0.13517694493735 no 2944 0.116001950902076 4290 5333628 SGTC_524 r073-0010 27.8 µM -1.1955186902578 0.135115881315733 no 2945 0.115942219159707 4210 2772106 SGTC_152 4469-0003 551.229 µM -1.19584560041169 0.1350506441429 no 2946 0.115878408583571 4266 697280 SGTC_3121 9125696 49.47 µM -1.19806288205785 0.134608740457435 no 2947 0.115446268817501 4394 1235365 SGTC_183 3914-0051 30.55 µM -1.19955477220827 0.134311966253847 no 2948 0.115156150347253 4315 1596232 SGTC_1450 4112-4260 37.6 µM -1.20188223619253 0.133849873423132 no 2949 0.114704578884722 4296 1633175 SGTC_2442 5158906 48.48 µM -1.20239671317963 0.133747877215668 no 2950 0.114604931017972 4286 1893835 SGTC_2643 anethole 100 µM -1.20248276957935 0.133730821560464 no 2951 0.114588268967726 4273 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_819 1013-0258 27.7 µM -1.20517287603485 0.133198418888877 no 2952 0.114068285543225 4289 5753198 SGTC_2272 7805186 180 µM -1.20542535814187 0.133148524784712 no 2953 0.114019568503037 4311 2956062 YPR165W RHO1 SGTC_2337 9009472 200 µM -1.20649828174817 0.132936643086889 no 2954 0.113812710604561 4282 5742383 SGTC_1409 3909-8004 61.9 µM -1.2065157041203 0.132933204421175 no 2955 0.113809353808252 4336 2119279 SGTC_564 3555-0129 330 µM -1.20668743362166 0.132899313326666 no 2956 0.113776270185907 4168 563260 SGTC_2459 5811157 9.22 µM -1.20888762216268 0.132465628912645 no 2957 0.113353011078237 4250 2870684 YBR192W RIM2 SGTC_1893 st059353 36.1 µM -1.21001160317019 0.132244455085913 no 2958 0.113137220273577 4306 3112488 SGTC_1093 fluphenazine 7.97 µM -1.21056314682796 0.132136017034057 no 2959 0.113031437815282 4312 6602611 An atypical antipsychotic. SGTC_2789 5281112 71.43 µM -1.21130416433372 0.131990423394753 no 2960 0.112889426666384 4299 765948 SGTC_892 0929-0076 29 µM -1.21195459804816 0.131862718688188 no 2961 0.112764880309664 4268 5751038 SGTC_3045 9092950 49.47 µM -1.21290868670277 0.131675549301767 no 2962 0.112582367047936 4280 44120432 SGTC_534 k292-0788 63.4 µM -1.21290974360596 0.131675342064335 no 2963 0.112582164983733 4349 4146317 SGTC_791 1348-1292 225 µM -1.21525444193286 0.13121614796309 no 2964 0.112134530981716 4273 5437054 SGTC_1314 1222-0010 41.1 µM -1.21656340417425 0.130960277736562 no 2965 0.111885186807839 4314 3526027 SGTC_1553 gossypol 38.6 µM -1.21871728535961 0.130539997242546 no 2966 0.11147575750257 4180 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3032 9089427 49.47 µM -1.22012961551367 0.130264920248215 no 2967 0.111207871656462 4299 17173707 SGTC_1137 ixabepilone 100 µM -1.2202126519401 0.130248759885058 no 2968 0.11119213595588 4261 154225 A novel microtubule stabilizer. SGTC_2145 5634607 200 µM -1.22924235958699 0.128499690094055 no 2969 0.109490475650363 4293 308662 SGTC_273 hydroxyurea 18.1 mM -1.23006439348355 0.128341274210915 no 2970 0.109336496162339 4369 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_601 0986-0029 62.9 µM -1.23230930089753 0.127909344332276 no 2971 0.108916783387836 4249 24747981 SGTC_672 1441-0018 53.7 µM -1.23352090894891 0.127676645860229 no 2972 0.108690740354304 4315 251141 SGTC_1236 0330-0013 258 µM -1.23362586296306 0.127656502508209 no 2973 0.108671175552772 4319 4617066 SGTC_566 0958-0068 16.5 µM -1.24122159333847 0.126204550454743 no 2974 0.107261950001555 4223 6815365 SGTC_456 gingerol 170 µM -1.24228936007791 0.126001369349729 no 2975 0.107064909805765 4374 442793 A herb. SGTC_2762 leflunomide 42.06 µM -1.24530949617865 0.125427914901568 no 2976 0.106509003179477 4298 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_799 1310-0557 151 µM -1.2469105403533 0.125124653331965 no 2977 0.106215150738016 4362 5354492 SGTC_3317 9138495 8.753 µM -1.24893358813361 0.12474219081961 no 2978 0.105844682661398 4236 17020139 SGTC_3230 9131665 49.47 µM -1.24911123771761 0.124708644761234 no 2979 0.105812195468261 4306 15943720 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.24950259517238 0.124634765904655 no 2980 0.10574065244923 4305 2724 A muscle relaxant with antifungal properties. SGTC_321 4534-3890 65.3 µM -1.25334285408622 0.123911440301742 no 2981 0.105040479436492 4320 699746 SGTC_2797 7859098 81.82 µM -1.25373865007304 0.123837058159282 no 2982 0.104968507364436 4308 972681 SGTC_538 2922-0838 53.3 µM -1.25463116081069 0.123669442879611 no 2983 0.104806343044482 4339 777039 SGTC_57 miconazole 162.5 nM -1.25753060340638 0.123126018365664 no 2984 0.104280782252825 4193 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2741 miltefosine 3.04 µM -1.25957022325184 0.12274474926282 no 2985 0.10391222144378 4362 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_489 paxilline 115 µM -1.26041910923813 0.122586310063008 no 2986 0.103759105859272 4318 105008 A toxic potassium channel blocker. SGTC_1178 0988-0033 191 µM -1.26047391386765 0.122576086058505 no 2987 0.10374922624536 4371 5392207 SGTC_2326 6164455 177.58 µM -1.26674044067168 0.121410985401887 no 2988 0.102624057346935 4289 2888790 SGTC_2159 5658611 73.75 µM -1.26790610682563 0.121195121259167 no 2989 0.102415741511097 4331 793844 SGTC_2481 5478948 45.16 µM -1.26971369632522 0.120860916500996 no 2990 0.102093316129315 4356 77792 SGTC_3262 9137218 49.47 µM -1.27425441062164 0.120024247573595 no 2991 0.101286633842441 4286 17650664 SGTC_1359 1582-0056 520 nM -1.27729136462051 0.119466943718118 no 2992 0.100749700586798 4412 3661189 SGTC_173 1273-0061 2.693 µM -1.28244195905196 0.118525949600546 no 2993 0.0998438265658792 4319 2847414 YPL266W DIM1 SGTC_882 0843-0131 351 µM -1.28579721312755 0.117915781956656 no 2994 0.0992569215508441 4343 5425421 SGTC_1765 st044815 90.4 µM -1.28581178831438 0.117913136251926 no 2995 0.0992543775565304 4384 645695 SGTC_573 3702-0553 84.7 µM -1.28627029970133 0.117829928176987 no 2996 0.0991743720218571 4294 1222756 SGTC_2829 7992743 58.44 µM -1.28754188980055 0.117599384555063 no 2997 0.0989527393665354 4352 16462845 SGTC_224 benfluorex 43.875 µM -1.29319341934529 0.116578606682158 no 2998 0.0979720855457675 4388 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.2938587916148 0.116458842025276 no 2999 0.097857100363038 4361 5024745 SGTC_2624 nerol 100 µM -1.29549453072667 0.116164785842704 no 3000 0.0975748434342712 4277 637566 A natural product oil. SGTC_508 roscovitine 141 µM -1.29606026197302 0.116063207300681 no 3001 0.0974773620839379 4432 160355 A CDKinase inhibitor. SGTC_3126 9127922 49.47 µM -1.30130296869482 0.115124864155341 no 3002 0.0965773857404191 4376 45595682 SGTC_843 0310-0051 143 µM -1.3021616221536 0.114971697304839 no 3003 0.0964305707214158 4388 2065037 SGTC_295 k015-0027 31 µM -1.30234697741722 0.114938652608144 no 3004 0.0963988996824944 4430 3887424 SGTC_2855 9016525 58.44 µM -1.3043398786305 0.114583789624844 no 3005 0.0960588620521821 4313 43811474 SGTC_2565 isoliquiritigenin 100 µM -1.30525496076413 0.114421108373257 no 3006 0.0959030224693705 4405 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1334 1486-0610 236 µM -1.30672890342172 0.114159419992224 no 3007 0.0956523993644224 4429 3742339 SGTC_452 diindolylmethane 8 µM -1.30872327431898 0.113806012177998 no 3008 0.0953140524434178 4364 3071 Inhibits expression of several cancer promoting factors. SGTC_2222 6885208 172.143 µM -1.31191663477339 0.11324176522304 no 3009 0.094774132079168 4364 609514 SGTC_682 0kpi-0099 17 µM -1.31301666709412 0.113047859273629 no 3010 0.0945886660026976 4388 1714895 YML126C ERG13 SGTC_2843 9000894 45.46 µM -1.3136339061072 0.112939160564423 no 3011 0.0944847164041443 4345 2242070 SGTC_1203 3992-3522 103 µM -1.31979250259744 0.111858686705919 no 3012 0.0934521527399605 4477 5322312 SGTC_2448 5185112 27.17 µM -1.32042397244991 0.111748319912577 no 3013 0.093346752090196 4381 5718189 SGTC_110 0850-0284 111.64 µM -1.32486841186273 0.110973734376667 no 3014 0.0926073997164436 4267 3906265 SGTC_1875 nocodazole 6 µM -1.32501415085096 0.110948399986662 no 3015 0.0925832289467823 4414 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_163 TUB2.036 7.546 µM -1.32718115557991 0.110572189589172 no 3016 0.0922243822366335 4335 15992207 YJR013W GPI14 SGTC_401 neomycin 50 µM -1.32814216561598 0.110405643092833 no 3017 0.0920655730168993 4372 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1822 st052468 42 µM -1.33252155706224 0.109648956229373 no 3018 0.0913444312770621 4395 2873678 SGTC_1247 0448-0043 5.84 µM -1.33294540000909 0.109575921232679 no 3019 0.0912748611554193 4388 3089013 YGL099W LSG1 SGTC_1009 4106-0057 9.87 µM -1.33321629276899 0.109529260328863 no 3020 0.0912304170553933 4386 2928005 SGTC_1344 1488-0097 29.1 µM -1.33352922819464 0.109475375398204 no 3021 0.091179095190778 4423 747966 SGTC_2196 6573537 42.6665 µM -1.3350968123218 0.109205736731354 no 3022 0.0909223313206205 4411 2903087 SGTC_963 1269-2853 151 µM -1.33592051521641 0.109064243773058 no 3023 0.0907876273320768 4377 3668223 SGTC_425 3825-7017 13.1 µM -1.34104064051731 0.108187679962048 no 3024 0.0899536290076302 4416 3397440 SGTC_2184 6075246 200 µM -1.34452332597089 0.107594350296159 no 3025 0.0893896093512532 4377 2267320 SGTC_348 k064-0012 10.7 µM -1.34663250273641 0.107236161155325 no 3026 0.0890493103498437 4334 5066323 SGTC_1113 artemisinin 1.17947 µM -1.35048291957821 0.106584486394001 no 3027 0.0884305644332976 4437 2240 An anti-malaria and mitochondrial poison. SGTC_970 1315-0089 19.5 µM -1.35233415742222 0.106272187992924 no 3028 0.0881342210487106 4369 6811083 YLR033W RSC58 SGTC_565 1418-0001 44.5 µM -1.35382670800902 0.10602088071791 no 3029 0.0878958353478201 4449 2862145 SGTC_2483 5729050 27.16 µM -1.3580811958201 0.105306891158832 no 3030 0.0872189606307552 4402 2865180 SGTC_3015 9080845 49.47 µM -1.35872068335407 0.105199873596281 no 3031 0.0871175576940543 4457 5296973 SGTC_3310 9130229 44.1445 µM -1.36174623089794 0.104694618313667 no 3032 0.0866389928952282 4429 7761258 SGTC_1648 st011736 69.8 µM -1.36319135379347 0.104453909286329 no 3033 0.0864111057380035 4397 2855514 SGTC_3147 9097027 49.47 µM -1.36647317717163 0.103908757418309 no 3034 0.0858952471093745 4415 25236841 SGTC_237 nikkomycin 200 µM -1.36704788558957 0.103813503873048 no 3035 0.0858051482849902 4435 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2344 7990960 76.95 µM -1.36811805668326 0.103636299976776 no 3036 0.0856375627743696 4394 140813 SGTC_848 0368-0089 85.6 µM -1.36817671096418 0.103626594076869 no 3037 0.0856283847827914 4398 762535 SGTC_1922 5578187 25 µM -1.3687979451993 0.103523834951043 no 3038 0.0855312216936216 4423 1350412 SGTC_628 1636-0253 16 µM -1.37100924145208 0.103158661832513 no 3039 0.0851860375997339 4401 4456143 SGTC_3257 9139206 32.98 µM -1.3729427593849 0.102840128317208 no 3040 0.0848850711134891 4422 4910041 SGTC_2859 9028643 45.46 µM -1.3738234656395 0.102695275280208 no 3041 0.0847482471644129 4246 17151580 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.37496007840387 0.102508551603091 no 3042 0.0845719108582404 4426 115019 SGTC_1785 bathophenanthroline 24 µM -1.37629922478004 0.102288872413423 no 3043 0.0843645064144915 4340 72812 An iron chelator. SGTC_1007 4101-0031 70 µM -1.37666640427198 0.102228698605619 no 3044 0.0843077050805781 4405 1146276 SGTC_1383 3049-0032 20.7 µM -1.38596023870138 0.100714178156669 no 3045 0.0828795225127047 4475 712864 SGTC_2277 7947813 106.88 µM -1.3868765789811 0.10056574259965 no 3046 0.0827397003600349 4451 1246798 SGTC_1975 st070967 30.8 µM -1.38892408024319 0.100234650080246 no 3047 0.0824279186179996 4411 261391 SGTC_207 4185-0010 4.486 µM -1.39021845337525 0.100025753538386 no 3048 0.0822312757623291 4503 3761753 SGTC_1654 st012436 41.8 µM -1.39043052010638 0.0999915588022165 no 3049 0.082199092021754 4424 4323132 SGTC_2899 9053889 58.44 µM -1.39080419802059 0.0999313258180774 no 3050 0.0821424048812012 4407 6470052 SGTC_1413 3910-0535 34.4 µM -1.39093841244389 0.0999096983214805 no 3051 0.0821220516706001 4446 2876951 SGTC_1127 asiatic acid 681.4 nM -1.39130050702121 0.0998513669566379 no 3052 0.0820671600757624 4388 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_359 0081-0058 15.9 µM -1.39436313816666 0.0993589893335313 no 3053 0.0816039867822585 4466 3494159 SGTC_711 k292-0785 179 µM -1.39650892201997 0.0990150717920444 no 3054 0.0812806478855912 4367 4146315 SGTC_1010 4112-3296 15.2 µM -1.39904003097672 0.0986105162609554 no 3055 0.0809004895698499 4467 704384 SGTC_2343 7990716 14.84 µM -1.39989000376688 0.0984749340455274 no 3056 0.0807731299591215 4434 6456862 SGTC_3290 9121031 71.43 µM -1.4028703096408 0.0980006131107474 no 3057 0.0803277579679431 4452 17014854 SGTC_3042 9091578 49.47 µM -1.40341394428977 0.0979142735447257 no 3058 0.0802467186061611 4429 25236497 SGTC_542 3381-0244 89.3 µM -1.4070280304356 0.0973417045207187 no 3059 0.0797095385743271 4460 1112843 SGTC_491 tetrandrine 80.3 µM -1.40909704437954 0.0970150243698879 no 3060 0.0794032373519485 4448 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1322 1348-1070 12 µM -1.41257742470845 0.0964673178427343 no 3061 0.0788900053583326 4443 6758089 SGTC_1988 st071872 53.4 µM -1.41345523950852 0.0963295358296675 no 3062 0.0787609566962187 4468 16414116 SGTC_1531 st059297 52.4 µM -1.41444577935732 0.0961742342083247 no 3063 0.0786155283379369 4469 7566702 SGTC_826 1683-5028 118 µM -1.4176092356998 0.0956794848973625 no 3064 0.0781524411149238 4486 722377 SGTC_1164 k060-0068 93.7 µM -1.41864271443537 0.0955182603220099 no 3065 0.0780016030754445 4454 5963676 SGTC_2239 6685329 187.64 µM -1.42044533633693 0.0952375266729991 no 3066 0.0777390360248475 4475 805680 SGTC_3072 9116419 49.47 µM -1.4305553602577 0.0936742809801108 no 3067 0.0762788444544698 4473 17170162 SGTC_1606 st000094 49.2 µM -1.43129084200369 0.0935613019683441 no 3068 0.0761734387506094 4472 1242210 SGTC_1044 1222-0021 1.78 µM -1.43187772738879 0.0934712213888294 no 3069 0.0760894087197521 4376 4306703 SGTC_3208 9114115 49.47 µM -1.43294959375167 0.0933068668188648 no 3070 0.0759361214498469 4427 650895 SGTC_1001 4048-4355 44.4 µM -1.43399628835341 0.0931465781031263 no 3071 0.0757866610224624 4446 21824233 SGTC_1400 3771-8998 51.5 µM -1.44690354178903 0.091186686688171 no 3072 0.0739619705210242 4416 670767 SGTC_2810 7959871 45.46 µM -1.4480886905929 0.0910082731844865 no 3073 0.0737961240235934 4417 2974535 SGTC_198 3454-2873 16.191 µM -1.45006012258931 0.0907120656300689 no 3074 0.0735208770483611 4477 710957 SGTC_1759 st043059 70 µM -1.45385224352933 0.0901443124806078 no 3075 0.0729936377572292 4463 669426 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.45604491278191 0.0898172346744583 no 3076 0.0726901021500621 4464 688669 SGTC_1005 4092-0690 4.4 µM -1.4602092945613 0.0891984689335136 no 3077 0.0721162808255312 4486 1529343 SGTC_1824 st053723 68.6 µM -1.46029688486811 0.0891854884510074 no 3078 0.0721042489158195 4486 675225 SGTC_2876 9059903 25.97 µM -1.46060355248818 0.0891400527893468 no 3079 0.0720621354079642 4465 6916095 SGTC_1282 0886-0010 32.4 µM -1.46207658844178 0.0889220488751388 no 3080 0.071860111712809 4494 2836211 YNL267W PIK1 SGTC_982 1491-0518 27.5 µM -1.46450810970951 0.0885630613885441 no 3081 0.0715275844417167 4424 3091256 SGTC_142 0335-0849 62.6745 µM -1.46661686242052 0.0882526022492269 no 3082 0.071240155146975 4442 3889043 YPR107C YTH1 SGTC_2980 9014342 25.29 µM -1.46896235409869 0.0879082431147788 no 3083 0.0709215001848049 4508 2996599 SGTC_1029 k015-0030 64.7 µM -1.46978770023173 0.0877873065470192 no 3084 0.0708096307010659 4491 2208316 SGTC_2469 5655019 90.81 µM -1.47106421896204 0.0876005048975941 no 3085 0.070636875217639 4536 2788239 SGTC_1171 0368-0077 21.4 µM -1.47928281699586 0.086404918210024 no 3086 0.0695323716633982 4469 3239779 SGTC_1998 st075797 76.8 µM -1.48015285519946 0.0862790685415804 no 3087 0.0694162293603174 4463 24208315 SGTC_2393 9031399 185.94 µM -1.48262939701135 0.0859215911649746 no 3088 0.069086451138593 4481 1526623 YDL150W RPC53 SGTC_470 aa-861 153 µM -1.4834172278683 0.0858081041238359 no 3089 0.0689817964925969 4435 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2911 7942208 15.64 µM -1.48347692982428 0.0857995086321128 no 3090 0.0689738707292821 4497 1243384 SGTC_735 3076-0345 636 µM -1.48404181812727 0.0857182116558861 no 3091 0.0688989134335884 4509 2888990 SGTC_716 1683-5115 658 µM -1.48640573052122 0.0853786302226896 no 3092 0.0685859174879885 4480 723597 SGTC_1448 4255-0083 152 µM -1.48771378545983 0.0851911587302166 no 3093 0.0684131952532947 4508 5399660 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.48840100294275 0.0850927898408485 no 3094 0.0683225861308129 4508 5357218 A potent inhibitor of glutathione S-transferases. SGTC_943 3253-1379 105 µM -1.4895036598581 0.0849351325066042 no 3095 0.0681773951579786 4468 668464 SGTC_2646 retinol 96.75 µM -1.48964728949063 0.0849146125431534 no 3096 0.0681585004494569 4481 445354 A vitamin A analog and teratogen. SGTC_1631 benzylvanillin 81.9 µM -1.49265749626941 0.084485407463565 no 3097 0.067763432311174 4521 75506 SGTC_2917 7979103 53.79 µM -1.49321046548083 0.0844067405755487 no 3098 0.0676910517427635 4482 2980565 SGTC_1876 myriocin 605 nM -1.494990224411 0.0841539203949262 no 3099 0.0674584967068368 4480 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1370 2001-0092 44.6 µM -1.49636741012489 0.0839586774069353 no 3100 0.06727896867527 4476 790957 SGTC_2795 7780010 54.55 µM -1.49875914466475 0.0836204109140349 no 3101 0.0669680634858023 4451 953673 SGTC_188 3229-0966 278.469 µM -1.49990282534031 0.0834590208451674 no 3102 0.0668197880144329 4545 5722370 SGTC_73 0327-0325 16.231 µM -1.50399710158738 0.0828831775069166 no 3103 0.0662910565165255 4303 53298 SGTC_607 4491-0986 66.8 µM -1.50730530093573 0.0824200801179241 no 3104 0.0658662097343285 4492 698981 YDR232W HEM1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.50820699126685 0.0822941957401498 no 3105 0.0657507792640937 4543 1609 A potent and irreversible inhibitor of serine proteases. SGTC_895 0964-0006 13.7 µM -1.50844849304823 0.0822605044361197 no 3106 0.0657198898966072 4499 6738897 SGTC_2045 5106652 78.05 µM -1.51004213937988 0.0820384392650089 no 3107 0.0655163359935414 4497 673349 SGTC_2533 agelasine 13.65 µM -1.51181948759375 0.0817913094105458 no 3108 0.0652898952168719 4531 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1758 st042942 75.2445 µM -1.51205829397068 0.08175814758992 no 3109 0.0652595167220664 4473 669317 SGTC_2216 7189485 200 µM -1.53427364354455 0.078717341629009 no 3110 0.0624811734683743 4534 731273 SGTC_606 k015-0008 38.6 µM -1.53448111649846 0.0786893525782942 no 3111 0.0624556676783629 4575 1970475 SGTC_588 3970-1144 52.9 µM -1.53505814373365 0.0786115486204293 no 3112 0.0623847732359915 4420 1888707 SGTC_1696 st025591 34.7925 µM -1.53557361035664 0.0785420945595678 no 3113 0.062321495305739 4510 2787147 SGTC_2315 7733312 200 µM -1.53739421024942 0.0782971588602365 no 3114 0.0620984016668625 4423 726316 SGTC_501 nsc-95397 161 µM -1.54018315593704 0.077923070001046 no 3115 0.0617578572652982 4520 262093 SGTC_3231 9132313 49.47 µM -1.54639355239707 0.0770949273081421 no 3116 0.0610047751819183 4474 4905967 SGTC_2064 5220758 200 µM -1.54863660299225 0.0767974711760605 no 3117 0.0607345508717375 4543 788518 SGTC_1825 st052143 62.6 µM -1.54869006462899 0.0767903921664876 no 3118 0.060728121693475 4556 674173 SGTC_1232 0279-0259 161 µM -1.54952311679764 0.0766801494132444 no 3119 0.0606280094330873 4514 1560000 SGTC_1027 k015-0025 8.67 µM -1.55686277217364 0.0757140450464425 no 3120 0.0597515349035199 4495 3598955 SGTC_3180 9109287 49.47 µM -1.55701108072964 0.0756946194990562 no 3121 0.0597339273125705 4548 18891271 SGTC_384 k007-0144 5.16 µM -1.56226453099318 0.0750089657824944 no 3122 0.0591128420296468 4479 6824886 SGTC_333 3486-0131 40.1 µM -1.57290455114821 0.0736348099013961 no 3123 0.0578704605665281 4535 6744690 SGTC_648 0375-0473 33.3 µM -1.5748550531286 0.0733850038576263 no 3124 0.0576449527256481 4517 1713139 SGTC_3080 9117754 49.47 µM -1.57897123626129 0.0728599611005904 no 3125 0.0571713273927584 4531 9550191 SGTC_2034 5197015 53.07 µM -1.58005332526075 0.0727224129667292 no 3126 0.0570473274966457 4535 780676 SGTC_1691 st019933 84.6 µM -1.58110799333863 0.0725885418336518 no 3127 0.0569266736946427 4531 6176082 SGTC_2703 st077852 53.4 µM -1.58154712223364 0.0725328580108219 no 3128 0.0568764967306472 4571 6281836 SGTC_284 0988-0104 32.6 µM -1.58418203303977 0.0721994246038652 no 3129 0.0565761503600037 4521 4666532 SGTC_1990 st072050 59.8 µM -1.58679304236282 0.0718701759095843 no 3130 0.0562797625783556 4531 17233948 SGTC_276 colchicine 750 µM -1.58817142307026 0.0716968268909943 no 3131 0.0561237906013848 4565 2833 A microtubule depolymerizer. SGTC_22 0964-0034 14.468 µM -1.59419086134262 0.0709435621838659 no 3132 0.0554466463737666 4552 138402 SGTC_786 4544-0069 423 µM -1.59721882633041 0.0705669519091112 no 3133 0.0551084687962257 4530 748821 YLR208W SEC13 SGTC_2959 9079155 11 µM -1.59855044556547 0.0704018159319328 no 3134 0.0549602640293758 4556 16189457 SGTC_1338 1486-1223 76 µM -1.6006275758664 0.0701448214833475 no 3135 0.0547297154025699 4545 3444526 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.60479894639709 0.0696308960933094 no 3136 0.0542690289659784 4576 94937 An inhibitor of serotonin biosynthesis. SGTC_743 1275-0778 158 µM -1.61918313113071 0.0678809363011436 no 3137 0.0527039332014163 4526 2849257 YMR203W TOM40 SGTC_2463 5473429 200 µM -1.62063185876209 0.0677065857894178 no 3138 0.0525483077111808 4560 5399405 SGTC_3105 9121040 49.47 µM -1.62088953126574 0.0676756118582103 no 3139 0.0525206662111161 4534 41448907 SGTC_1496 4469-0713 57.4 µM -1.62246420278646 0.0674865637774297 no 3140 0.0523519959526082 4551 746691 SGTC_3318 9139014 38.6185 µM -1.62375611800187 0.0673317671475318 no 3141 0.0522139344380488 4545 16643984 SGTC_1921 5740136 50 µM -1.62504147072399 0.0671780293541743 no 3142 0.0520768613449771 4492 1774243 SGTC_817 1391-0715 46 µM -1.62584310703986 0.0670822851720583 no 3143 0.0519915177649496 4545 1353946 SGTC_2325 6158266 200 µM -1.62639275409552 0.067016698570592 no 3144 0.0519330656377533 4532 3623240 SGTC_3225 9130819 49.47 µM -1.62938057308163 0.0666610444599353 no 3145 0.0516162393771175 4523 4547121 SGTC_3271 9137798 49.47 µM -1.63184313571689 0.0663690136541934 no 3146 0.0513562678316634 4550 6498326 SGTC_2276 7947513 42.08 µM -1.63296584998892 0.0662362022286899 no 3147 0.051238089610993 4485 2105100 SGTC_2310 7668677 200 µM -1.63520601332827 0.0659718174320502 no 3148 0.051002934001854 4530 2197143 SGTC_978 1416-0512 87.4 µM -1.63678484715627 0.0657859747283633 no 3149 0.0508377164854458 4588 6814003 SGTC_2978 9011784 42.97 µM -1.63843830956195 0.0655917828616584 no 3150 0.0506651465437263 4547 2994934 SGTC_1382 3002-2117 298 µM -1.63910020655521 0.0655141706700575 no 3151 0.0505961960267876 4607 1497314 SGTC_1689 st020265 53.493 µM -1.64505218506067 0.064819454329392 no 3152 0.0499795249261428 4555 5758320 YPR016C TIF6 SGTC_2570 licareol 100 µM -1.65157306707454 0.0640649161715438 no 3153 0.0493108071070275 4532 443158 SGTC_2370 9071495 200 µM -1.65469247822309 0.0637063889721983 no 3154 0.0489934468087999 4584 21791103 SGTC_1058 3448-5425 97.3 µM -1.66185735016633 0.0628888108146409 no 3155 0.0482706899781578 4513 7279705 SGTC_2971 9092186 9.93 µM -1.66255373912838 0.0628097842714457 no 3156 0.0482008988970453 4539 25236400 SGTC_3243 9134147 49.47 µM -1.66350251373491 0.0627022414410408 no 3157 0.0481059440463801 4662 24282180 SGTC_2833 9001315 45.46 µM -1.66600700303971 0.0624190489735841 no 3158 0.047856009804854 4511 2989378 SGTC_1999 st074831 12.5 µM -1.66892568409496 0.0620902816875743 no 3159 0.0475660543825118 4562 17112523 SGTC_417 st075190 100 µM -1.67095798190128 0.0618621577583917 no 3160 0.0473649887734566 4570 222757 SGTC_1866 st057638 64 µM -1.67193737004861 0.0617524560107197 no 3161 0.0472683363858537 4583 688802 SGTC_1435 4092-0789 56.7 µM -1.67451385347853 0.0614645880776309 no 3162 0.0470148270304848 4588 2248285 SGTC_1851 st056236 18.9 µM -1.67579295931118 0.0613220647357146 no 3163 0.0468893768555842 4547 5393171 SGTC_3334 9142812 21.919 µM -1.67631505256723 0.0612639651680087 no 3164 0.0468382490139298 4569 45283678 SGTC_983 1491-0821 12.2 µM -1.67725251084138 0.0611597509206752 no 3165 0.0467465573144349 4577 46495113 SGTC_1085 doxorubicin 7.67 µM -1.67968975011499 0.0608894590714595 no 3166 0.0465088475431558 4588 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2016 5121758 140 µM -1.68130818698985 0.060710489720502 no 3167 0.0463515342453144 4504 2795203 SGTC_1492 4158-0558 28.5 µM -1.6866373795332 0.060124085718272 no 3168 0.0458365499093337 4598 3967268 SGTC_1697 st025554 27.742 µM -1.68712539849578 0.0600706083843858 no 3169 0.0457896211197435 4609 1269519 SGTC_2354 9060492 162 µM -1.69493879140027 0.0592194755640304 no 3170 0.045043516371717 4580 6471895 SGTC_3166 9102297 49.47 µM -1.69521173036704 0.0591899154657106 no 3171 0.0450176312175082 4606 25237072 SGTC_266 formosanin C 406 nM -1.69913123488122 0.0587666965943726 no 3172 0.0446472296720832 4447 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3034 9090421 49.47 µM -1.69963818993959 0.058712130674854 no 3173 0.0445995011272056 4540 17173761 SGTC_581 0958-0271 211 µM -1.70172655053305 0.0584877699879624 no 3174 0.044403320425778 4600 4591145 SGTC_2171 5739187 198.077 µM -1.70534005234932 0.0581011483283969 no 3175 0.0440655108807554 4564 2262761 SGTC_967 1306-0166 352 µM -1.71161348697337 0.05743470358779 no 3176 0.0434839605928861 4591 4437607 SGTC_2086 5274770 176.623 µM -1.71181991764971 0.0574128765045736 no 3177 0.0434649301665584 4623 689278 SGTC_2048 5246248 200 µM -1.71265496954896 0.0573246483311089 no 3178 0.0433880170161118 4607 677046 SGTC_955 1216-0110 33 µM -1.71396583886712 0.057186362464635 no 3179 0.0432674999786645 4571 3619719 SGTC_2468 5987765 72.9 µM -1.72269066735425 0.0562726436166929 no 3180 0.0424722394605968 4635 26772094 SGTC_1888 azatryptophan 97.5 µM -1.72660086946848 0.055866895665001 no 3181 0.0421196848426988 4607 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1563 conessine 56.1 µM -1.72724488660375 0.0558002901995932 no 3182 0.0420618462919677 4644 441082 An anti-amoebic, histamine inhibitor. SGTC_1117 retinoic acid 1.10837 µM -1.73213961581173 0.0552961137780132 no 3183 0.0416243535803348 4634 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1159 4092-0538 61.2 µM -1.73256304849946 0.0552526681619196 no 3184 0.0415866808887279 4617 717301 SGTC_2218 6965428 192.983 µM -1.73859885873025 0.0546363005259724 no 3185 0.0410526737123179 4522 675684 SGTC_2998 9066762 71.4286 µM -1.74154764896769 0.0543371579442914 no 3186 0.0407938143236602 4605 4945196 SGTC_2411 st077133 39.94 µM -1.75078196011808 0.0534087513306706 no 3187 0.0399917375880803 4566 1403142 YNL221C POP1 SGTC_3263 9137018 49.47 µM -1.75190214206177 0.0532969896803802 no 3188 0.0398953180859186 4570 43844957 SGTC_2286 7945697 125 µM -1.75591575706898 0.0528980686694037 no 3189 0.0395513970201965 4573 1245733 SGTC_2247 cerulenin 830 nM -1.75752528658809 0.0527387612375368 no 3190 0.039414157820415 4621 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1882 5615643 20 µM -1.76292328452518 0.0522072577813895 no 3191 0.0389567146505498 4605 2253075 SGTC_602 3130-1533 38.1 µM -1.76959174345649 0.0515565445752959 no 3192 0.0383975876393651 4641 720941 SGTC_687 k029-0044 34.9 µM -1.77163322313882 0.0513586299881715 no 3193 0.0382277305024023 4647 5829338 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.77188496244936 0.0513342666206987 no 3194 0.0382068275502331 4596 756377 SGTC_3174 9107204 49.47 µM -1.77635969817782 0.0509027332773701 no 3195 0.0378368246622829 4615 3938802 SGTC_64 000l-0018 272.079 µM -1.7897237468633 0.049631108267949 no 3196 0.036749166446777 4537 6811119 SGTC_1871 st057448 67.3 µM -1.79666930170215 0.0489803023227588 no 3197 0.0361940676138939 4610 691747 SGTC_3108 9121785 49.47 µM -1.7981800291428 0.0488396522823191 no 3198 0.0360742416334182 4516 17140271 SGTC_1064 honokiol 6.76 µM -1.79947576923016 0.0487192750484512 no 3199 0.0359717267466622 4620 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_63 0099-0242 26.702 µM -1.79963436680414 0.0487045572734388 no 3200 0.0359591954122537 4634 3898502 YLR359W ADE13 SGTC_883 0850-0245 24.6 µM -1.80495027766677 0.048213296067421 no 3201 0.0355412315568092 4654 6823229 YPR165W RHO1 SGTC_2875 9039966 71.43 µM -1.80732029377738 0.0479955564534085 no 3202 0.035356176813166 4627 6463691 SGTC_1839 st053978 48 µM -1.80742108805426 0.0479863136949334 no 3203 0.0353483241821447 4647 3788398 SGTC_2848 9016370 25.97 µM -1.80810630800818 0.0479235173040919 no 3204 0.0352949783098457 4600 7894410 SGTC_2854 9024559 71.43 µM -1.814963143953 0.0472987448573215 no 3205 0.0347647867968063 4612 3163529 SGTC_2653 dihydrofissinolide 100 µM -1.81701140233649 0.0471133857612387 no 3206 0.0346076837212121 4710 6857746 SGTC_1143 3454-2408 5.08 µM -1.8247786771644 0.046415764405186 no 3207 0.0340172174194243 4651 X1143 SGTC_2303 7774051 200 µM -1.82716988640934 0.04620267411654 no 3208 0.0338371150404601 4624 2953184 SGTC_1868 st057644 42.7 µM -1.83044764598722 0.0459118570659763 no 3209 0.0335915143083571 4654 688665 SGTC_2761 levamisole 97.89 µM -1.83636892812174 0.0453902250715624 no 3210 0.0331515558875779 4634 26879 An alkaline phosphatase inhibitor. SGTC_8 0354-0001 70 µM -1.83921745170387 0.0451409896721401 no 3211 0.03294160440602 4633 4993152 SGTC_2170 morpholine 200 µM -1.84177875078094 0.0449178267361625 no 3212 0.0327537597450603 4670 121171 Reacts with secondary amines. SGTC_1944 st076371 56.9 µM -1.84208945637484 0.0448908158357544 no 3213 0.0327310329034466 4613 24208455 SGTC_3143 9086658 49.47 µM -1.84290654857171 0.0448198450966492 no 3214 0.0326713280075465 4592 25236626 SGTC_1345 1488-0192 31.4 µM -1.85401178147045 0.0438641995166133 no 3215 0.0318687372422498 4676 658348 SGTC_1616 st002734 56.1 µM -1.86001002895453 0.0433549051993407 no 3216 0.0314420535351801 4626 4026101 SGTC_2082 5219693 150 µM -1.86006526393298 0.0433502376331631 no 3217 0.0314381464646659 4617 2834649 SGTC_1032 k061-1018 98.7 µM -1.86416695194428 0.0430047615410821 no 3218 0.0311491313823214 4667 4005393 SGTC_3242 9133940 49.47 µM -1.86689888652123 0.0427758934422384 no 3219 0.0309578547006135 4649 17248444 SGTC_133 0724-0033 378.92 µM -1.86804922662795 0.0426798186002291 no 3220 0.0308776048540066 4586 280309 SGTC_228 caffeine 993.056 µM -1.87198983938731 0.0423520256228583 no 3221 0.0306040046125284 4642 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_995 3931-2021 34.6 µM -1.8761005386115 0.0420122576826419 no 3222 0.0303207378801986 4636 730143 SGTC_869 0564-0080 44.1 µM -1.8845497816388 0.0413208179437769 no 3223 0.0297453238760034 4644 6843321 SGTC_1126 isoteolin 1.0172 µM -1.8881743118288 0.0410270470951043 no 3224 0.0295012766056092 4596 133323 SGTC_2134 5324836 1.464 µM -1.88847137898004 0.0410030448771465 no 3225 0.0294813483599805 4639 699272 SGTC_2690 usnic acid 100 µM -1.89056001658445 0.0408346099992234 no 3226 0.0293415509341523 4639 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1225 1216-0074 20.6 µM -1.89220458872772 0.0407023814662131 no 3227 0.0292318636129128 4648 4241466 SGTC_891 0929-0073 133 µM -1.89255552148154 0.0406742104531879 no 3228 0.0292085017485667 4671 5603632 SGTC_3157 9099274 49.47 µM -1.90527930842174 0.0396634542538246 no 3229 0.0283718868406609 4661 17217662 SGTC_1828 st055811 49 µM -1.90674962064505 0.0395479831377386 no 3230 0.0282765090080887 4653 5877589 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.90800108936133 0.0394499144573721 no 3231 0.0281955377397326 4643 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3 0833-0587 95.581 µM -1.9088748072667 0.0393815647567848 no 3232 0.0281391218184804 4562 5382644 SGTC_710 3448-4187 58 µM -1.9156995898427 0.0388509813041267 no 3233 0.0277016723403037 4646 3946412 SGTC_894 0960-0238 55.9 µM -1.91716703825231 0.0387376604423244 no 3234 0.0276083570685547 4651 6741907 YDL195W SEC31 SGTC_336 4111-0029 111 µM -1.93250212534256 0.0375694743795179 no 3235 0.026648779990899 4684 3131175 SGTC_3173 9105693 49.47 µM -1.93532608524194 0.0373575210470958 no 3236 0.0264751466408234 4649 17096658 SGTC_12 0849-0099 9.267 µM -1.94082595957514 0.0369475297064491 no 3237 0.0261396955624721 4657 6071388 SGTC_2598 perillyl alcohol 100 µM -1.95570963200491 0.0358564364841562 no 3238 0.0252496847153218 4657 10819 An apoptosis inducer. SGTC_3219 9131112 49.47 µM -1.95606195479745 0.0358309317340556 no 3239 0.0252289281075538 4552 17612988 YMR079W SEC14 SGTC_2092 5303694 80.6725 µM -1.95652258022528 0.0357976093467354 no 3240 0.025201812568359 4689 1963699 SGTC_896 0964-0007 44.5 µM -1.96558592907906 0.0351471012121376 no 3241 0.02467323039713 4641 6756758 SGTC_1624 st003710 6.25 µM -1.96658187354113 0.0350762140303544 no 3242 0.0246157174478802 4691 24207033 SGTC_193 1273-0060 1.558 µM -1.96991560528628 0.034839786027039 no 3243 0.0244240218191223 4566 2847393 YHR072W ERG7 SGTC_850 0388-0143 75.9 µM -1.9849341108865 0.0337908444950198 no 3244 0.0235759013328724 4690 67273 SGTC_2996 9066192 71.4286 µM -2.00519767330842 0.0324168863742527 no 3245 0.0224709593648173 4653 6472854 SGTC_2355 9061122 103.12 µM -2.01681648262983 0.0316500935818834 no 3246 0.0218573341068204 4693 5302957 SGTC_2877 9040724 71.43 µM -2.02333688197771 0.0312263812378413 no 3247 0.0215192134090521 4652 6463895 SGTC_309 k408-0051 1.48 µM -2.03000921926688 0.03079766351664 no 3248 0.0211778010879452 4619 3640463 SGTC_3259 9138485 49.47 µM -2.03727791026779 0.0303361855676073 no 3249 0.0208111000905832 4659 17646153 SGTC_1242 0402-0103 60.1 µM -2.04967421408363 0.029562388739959 no 3250 0.020198116467167 4631 432868 SGTC_2581 avocatin a 64 µM -2.05344969497196 0.0293299977957533 no 3251 0.0200144919165461 4627 6710728 A skin care supplement. SGTC_3100 9120536 49.47 µM -2.05733501819356 0.0290924317186989 no 3252 0.019827005559195 4632 16421196 SGTC_53 0973-0023 39.979 µM -2.06200608550206 0.0288089403747943 no 3253 0.019603578301183 4625 674768 SGTC_1011 4112-3381 17.4 µM -2.06781703496272 0.0284594779674479 no 3254 0.0193286156050673 4712 2877139 SGTC_1408 3909-7976 48.8 µM -2.09313573687477 0.0269777526296947 no 3255 0.0181685196807917 4724 24152374 SGTC_886 0866-0150 153 µM -2.09375366632252 0.0269424101950138 no 3256 0.0181409647788136 4722 271463 SGTC_3063 1327-0034 4 µM -2.10325129832922 0.0264040384767802 no 3257 0.0177219041075486 4600 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2493 resveratrol 26.09 µM -2.10514679810288 0.0262976757373321 no 3258 0.0176392658302926 4694 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3021 9087658 49.47 µM -2.10836784608737 0.0261177536382146 no 3259 0.0174995917385427 4722 25237042 SGTC_1795 st049545 62.3 µM -2.11100238104085 0.0259713595188836 no 3260 0.01738605360229 4692 5291882 SGTC_539 4859-0462 2.54 µM -2.11527463933423 0.0257354208969101 no 3261 0.0172032733249204 4688 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_104 0074-0074 590.992 µM -2.13745027497459 0.0245393949679289 no 3262 0.0162806930054578 4659 3943124 SGTC_2347 9049783 174.81 µM -2.14740703700581 0.0240177575820305 no 3263 0.0158804454583805 4690 6467988 YPL169C MEX67 SGTC_1820 st053765 18.6 µM -2.15399303176092 0.0236778606234469 no 3264 0.0156203591927701 4730 3690829 SGTC_997 3996-0078 137 µM -2.15834828878714 0.0234553190955814 no 3265 0.0154503814847951 4728 735687 SGTC_2932 9016711 44.54 µM -2.17082598679394 0.0228274650729229 no 3266 0.0149721643881602 4691 7117328 SGTC_382 3229-0966 23.2 µM -2.17460981072386 0.0226398915540129 no 3267 0.0148296842581381 4734 5722370 SGTC_1796 st049173 110.4 µM -2.18563316896918 0.0221008273394044 no 3268 0.014421226954064 4712 94134 SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.193805334468 0.0217082202341715 no 3269 0.0141247035844376 4711 5282309 SGTC_75 0159-0059 199.013 µM -2.20321902816455 0.0212632864735828 no 3270 0.0137896573953947 4712 5377270 SGTC_54 0159-0055 9 µM -2.22486676675663 0.0202693015255993 no 3271 0.0130450918014412 4710 3319099 SGTC_640 3381-0960 37.1 µM -2.22689746700689 0.020178113758752 no 3272 0.0129770635888236 4761 1745025 SGTC_2584 androsterone 48.74 µM -2.22788797809586 0.0201337616323584 no 3273 0.0129439930268635 4636 2754130 A steroid. SGTC_1216 1165-0504 9.65 µM -2.24104529552994 0.0195524163098735 no 3274 0.0125115705641216 4741 6304004 SGTC_3109 9122853 49.47 µM -2.24759372252943 0.0192684329838135 no 3275 0.0123010541140793 4742 1234709 SGTC_2334 9017922 200 µM -2.25500568556059 0.0189512378202414 no 3276 0.0120664859555459 4717 3163164 SGTC_3199 9111318 49.47 µM -2.25812764081638 0.0188189690687703 no 3277 0.0119688514135216 4655 8548020 SGTC_844 0330-0132 15.3 µM -2.25936237981133 0.01876687372312 no 3278 0.0119304262669785 4741 2828079 SGTC_3033 9090887 49.47 µM -2.26272903429207 0.0186254529995052 no 3279 0.0118261989390852 4736 19325384 SGTC_3144 9087057 49.47 µM -2.26280116739481 0.0186224329083484 no 3280 0.0118239744626487 4676 17249618 SGTC_50 0929-0078 56.389 µM -2.26384077702067 0.0185789524885253 no 3281 0.0117919547637897 4642 1377751 SGTC_2492 derrusnin 100 µM -2.26901847940063 0.0183636863381078 no 3282 0.0116336010637963 4753 1715307 Part of coumarin class of compounds. SGTC_3235 9132602 49.47 µM -2.26963895327934 0.0183380328830363 no 3283 0.0116147490709694 4730 4912240 SGTC_236 1509-0011 5.31 µM -2.27990233679899 0.0179181028941961 no 3284 0.0113067407227001 4733 3107280 SGTC_634 1611-4317 11.2 µM -2.28487101217761 0.0177177716169562 no 3285 0.0111601961121608 4756 2843522 SGTC_304 1310-0298 97 µM -2.28611141602243 0.0176680591094864 no 3286 0.0111238706482835 4517 1550234 SGTC_3221 9128209 49.47 µM -2.29259187342746 0.0174102685836393 no 3287 0.0109357563428775 4747 16460723 SGTC_1927 st060202 13.8 µM -2.29649631272295 0.017256507144851 no 3288 0.0108237598738815 4697 688887 SGTC_87 0100-0052 35.5 µM -2.3044116294862 0.0169483498309794 no 3289 0.0105997739014489 4728 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2049 5262831 67.185 µM -2.31042193020374 0.016717512032178 no 3290 0.0104324030630376 4707 763417 SGTC_3253 9135987 49.47 µM -2.31160950707807 0.016672220382892 no 3291 0.0103996061247526 4741 4182430 SGTC_667 1498-1044 59 µM -2.33428076236114 0.0158275096828266 no 3292 0.00979051269346853 4745 6739982 SGTC_738 1315-0003 72.4 µM -2.33826695849611 0.0156828460172408 no 3293 0.00968670196230227 4747 6251474 SGTC_2597 laccaic acid a 100 µM -2.34736556886628 0.0153568908282846 no 3294 0.00945334719507063 4713 5491415 A textile dye. SGTC_378 3970-0959 8.33 µM -2.35093346354923 0.0152306691294234 no 3295 0.00936319104976727 4737 6615653 SGTC_1914 st062367 72.6 µM -2.36697739154796 0.0146740367148012 no 3296 0.0089670141580696 4724 978205 SGTC_1277 0873-0036 22 µM -2.37074131130558 0.0145460143820657 no 3297 0.00887622561884799 4771 5965735 SGTC_118 0083-0097 135.343 µM -2.38249378156109 0.0141524453556459 no 3298 0.00859791120252531 4713 5207356 SGTC_604 1000-0114 314 µM -2.38391910782039 0.0141053433919311 no 3299 0.00856468358430176 4768 1572745 SGTC_761 k216-0224 480 µM -2.384727010765 0.0140787051068776 no 3300 0.00854589958696408 4754 1340404 SGTC_2053 5265679 138 µM -2.38564012269729 0.0140486500586667 no 3301 0.00852471296850508 4696 764595 SGTC_2077 5212015 200 µM -2.39029349422408 0.0138963420247159 no 3302 0.00841745677915392 4724 780900 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.40032761206472 0.0135727569821446 no 3303 0.00819020208998017 4735 1377 SGTC_2968 9090663 33.37 µM -2.40977953622276 0.0132739158449273 no 3304 0.00798108140131489 4710 25236811 SGTC_2251 lansoprazole 556 µM -2.44649199231474 0.0121664644366963 no 3305 0.00721270008986654 4748 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_169 k015-0017 16.025 µM -2.4594747540294 0.0117944706413825 no 3306 0.00695702416563659 4709 1840002 SGTC_1896 st058441 89 µM -2.46963507996683 0.0115102710775364 no 3307 0.00676254722024412 4767 688759 SGTC_1156 4092-0367 4.88 µM -2.51946171178061 0.0102010264337023 no 3308 0.00587672112264057 4769 1357585 SGTC_3311 9131146 2.8755 µM -2.54054997806146 0.00968727206666891 no 3309 0.00553391370765452 4763 4900406 YPR165W RHO1 SGTC_3302 9125395 16.351 µM -2.54135572345195 0.00966809907985919 no 3310 0.00552117546477081 4736 17599668 SGTC_1074 carmofur 3.8 µM -2.558869986638 0.00925945774628669 no 3311 0.00525065036585605 4790 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1562 morin hydrate 59.1 µM -2.56061666856118 0.00921954535189734 no 3312 0.00522432869875228 4758 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2827 7993847 71.43 µM -2.57346757417627 0.00893049834617717 no 3313 0.0050342540531475 4757 2985692 SGTC_3068 9116768 49.47 µM -2.57884819516832 0.00881185339045953 no 3314 0.0049565169535815 4745 41904888 SGTC_2495 cafestol 54.53 µM -2.58009978230196 0.00878445424871171 no 3315 0.00493858854478536 4748 16667697 An anti-infammatory. SGTC_722 3534-0461 190 µM -2.58857809216441 0.00860080987537973 no 3316 0.00481865461523054 4767 658262 SGTC_1087 pterostilbene 9.05 µM -2.58865555924275 0.00859914754513055 no 3317 0.00481757084492692 4773 5281727 Similar to reservatol, lowers cholesterol. SGTC_3153 9100258 49.47 µM -2.59329748016726 0.0085000517276287 no 3318 0.00475302533952325 4719 25236848 SGTC_1473 k844-0725 134 µM -2.60924077644462 0.00816728467697485 no 3319 0.00453716843151337 4786 54682906 SGTC_2491 paeonol 100 µM -2.62766226567037 0.00779709309890263 no 3320 0.00429869134307502 4772 11092 Increases levels of cortical cytochrome oxidase. SGTC_493 zm226600 134 µM -2.64677453370491 0.00742870356858911 no 3321 0.00406317569287591 4769 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2128 5255449 168.493 µM -2.6737837349896 0.00693427235461818 no 3322 0.00375004003483799 4735 736008 SGTC_1201 1889-3372 45.9 µM -2.69255641363108 0.00660795868558454 no 3323 0.00354532693232615 4749 5392199 SGTC_99 0109-0120 622.8 µM -2.69978563546706 0.00648596502001688 no 3324 0.00346920832843949 4776 759414 SGTC_2918 7977171 22.06 µM -2.71821546624337 0.00618392909253933 no 3325 0.00328175403491975 4774 2236483 SGTC_1446 4239-0190 62 µM -2.72989242477692 0.00599907215832276 no 3326 0.003167749774837 4782 1340085 SGTC_103 0844-0104 51.839 µM -2.75212311834127 0.00566063485677791 no 3327 0.00296051279246963 4647 5375804 SGTC_1072 oxiconazole 14.9 nM -2.75913490800993 0.00555746254603161 no 3328 0.00289773021574001 4757 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1214 0358-0031 63.7 µM -2.78957006094724 0.00512874114970833 no 3329 0.00263890379946474 4764 4301366 SGTC_299 1273-0059 1.44 µM -2.83638047311273 0.00452668369789437 no 3330 0.00228140268786773 4624 2848077 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.93928655791838 0.00341959294004962 no 3331 0.00164484383408066 4795 16486 A toxic proline analog. SGTC_235 0330-0087 5 mM -2.97575038839192 0.00308999766696444 no 3332 0.00146136323679389 4797 46494818 YHR062C RPP1 SGTC_2606 farnesol 9.78 µM -3.04029778716205 0.00257597252222063 no 3333 0.00118172169730537 4778 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_38 0929-0051 58.268 µM -3.06018555192394 0.00243394869708135 no 3334 0.00110599951285275 4777 1379719 SGTC_3124 9127567 49.47 µM -3.10682195885382 0.00212828527019179 no 3335 0.00094555127979624 4786 17592030 SGTC_2804 7954240 19.48 µM -3.15643027584307 0.00184172569947155 no 3336 0.000798565332695309 4781 828705 SGTC_3190 9110366 49.47 µM -3.24045413765227 0.00143529895866309 no 3337 0.00059669733873605 4784 17123768 SGTC_2953 9074162 66.49 µM -3.27953122797209 0.00127574740150301 no 3338 0.00051989850869838 4786 16451992 SGTC_655 k060-0012 42 µM -3.28464837415958 0.00125610064973917 no 3339 0.00051054859068288 4802 5994525 SGTC_2414 st077232 92.9 µM -3.32447927501508 0.00111238281467732 no 3340 0.000442919086026643 4792 729801 SGTC_435 c-PAF 6.7 µM -3.33347294747853 0.00108209161659567 no 3341 0.000428845059329825 4766 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3112 9123419 49.47 µM -3.3539602442163 0.00101589196361367 no 3342 0.000398319038419817 4802 17015854 SGTC_2907 7721985 69.9 µM -3.36340639242569 0.000986638828039862 yes 3343 0.000384934700474544 4793 3267881 SGTC_2585 alliin 100 µM -3.54578863283056 0.000553566521143076 yes 3344 0.000195720022657895 4796 87310 A garlic compound which reacts with lipids. SGTC_3102 9121669 49.47 µM -3.5998410366275 0.00046407940222122 yes 3345 0.000159205887989143 4805 41905072 SGTC_840 0245-0196 390 µM -3.61679901514038 0.000438894778032523 yes 3346 0.000149134359390234 4809 3827528 SGTC_2629 bisabolol 100 µM -3.82358062002324 0.000218227465458802 yes 3347 6.57637790848651e-05 4804 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1502 4534-4282 27.7 µM -3.99079923469722 0.000120977876825822 yes 3348 3.29255035656737e-05 4810 3278949 SGTC_1838 st055369 84.5 µM -4.02182539805733 0.000108169016082879 yes 3349 2.88744298987304e-05 4804 676036 SGTC_2055 5235184 200 µM -4.11524057682713 7.68681810749118e-05 yes 3350 1.93387895910789e-05 4802 2836034 SGTC_310 1273-0058 1.06 µM -4.36882235747567 2.93561432722547e-05 yes 3351 6.24591622972644e-06 4657 2734232 SGTC_969 1313-0238 134 µM -4.38033528007609 2.80663815600198e-05 yes 3352 5.92484198867196e-06 4809 5212874 SGTC_1745 st081495 74 µM -5.35194922382289 4.30181072110582e-07 yes 3353 4.35059085651832e-08 4801 13842402 YBL026W LSM2 SGTC_3103 9120822 49.47 µM -5.48008962244317 2.34134263356789e-07 yes 3354 2.12555221453157e-08 4810 17141819 SGTC_453 enantio-paf c16 10 µM -10.7399216743296 2.77412601732092e-23 yes 3355 3.30502207011846e-27 4804 13871343 A lipid and platelet activating factor SGTC_58 0957-0393 9 µM -11.0994989659081 9.75376517640833e-25 yes 3356 6.30745371764835e-29 4792 6997992