SGTCid condition conc unit CPR2|YHR057C.score CPR2|YHR057C.strain.pval CPR2|YHR057C.strain.significant CPR2|YHR057C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1522 st012842 45.6 µM 6.33924181374421 1.88647833541383e-10 yes 1 1.15449298516204e-10 6 3491067 YOR116C RPO31 SGTC_24 0417-1663 219 µM 6.17815847942895 5.1328619930537e-10 yes 2 3.24267989722125e-10 5 4329390 SGTC_2804 7954240 19.48 µM 4.90621872190969 5.92091453056902e-07 yes 3 4.64244909843108e-07 12 828705 SGTC_1336 1486-0901 104 µM 4.65431677606218 2.00068014217694e-06 yes 4 1.62528369184299e-06 15 5006114 SGTC_53 0973-0023 39.979 µM 4.384215036392 6.91587569695335e-06 yes 5 5.82023733848362e-06 9 674768 SGTC_2859 9028643 45.46 µM 4.23576001557631 1.32883398302079e-05 yes 6 1.13889975707317e-05 11 17151580 SGTC_1734 st037168 69.4 µM 4.13736176891598 2.02586016254137e-05 yes 7 1.75660983489984e-05 17 708907 SGTC_918 glabranin 770.725 nM 4.13235947534367 2.06926717278206e-05 yes 8 1.79529143565728e-05 27 124049 Also referred to as licorice root. SGTC_2430 5571206 200 µM 3.95254890358333 4.36671470890909e-05 yes 9 3.86615599947132e-05 56 1731771 SGTC_2936 9038235 15.59 µM 3.86287799138283 6.2675493632816e-05 yes 10 5.60294914640732e-05 20 4749415 SGTC_1263 0774-1208 64.8 µM 3.79923555608748 8.0639909165332e-05 yes 11 7.25715454196798e-05 52 906585 SGTC_1938 st074717 56.4 µM 3.79762593211184 8.11516678396829e-05 yes 12 7.30442809084559e-05 13 17250979 SGTC_1271 0832-2808 169 µM 3.76573264911501 9.19440397330916e-05 yes 13 8.30307060192566e-05 15 3663794 SGTC_1608 st001473 40.5 µM 3.72140509141628 0.000109199907628168 yes 14 9.90586633459163e-05 42 7292267 SGTC_2064 5220758 200 µM 3.45441953896359 0.000296296464733143 yes 15 0.000275739372899985 59 788518 SGTC_1281 0884-0031 11.8 µM 3.44446997806457 0.000307141860761929 yes 16 0.000286090087364766 39 1548255 SGTC_217 ketoconazole 989 nM 3.41246962825602 0.00034457939545014 yes 17 0.000321885501284991 45 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1338 1486-1223 76 µM 3.37425877109854 0.000394827324055785 yes 18 0.000370073774704686 39 3444526 SGTC_831 k061-1017 217 µM 3.36978314386791 0.000401138356110792 yes 19 0.000376136802052443 100 1240153 SGTC_561 1550-0330 72.9 µM 3.33254056302779 0.000457401588054406 yes 20 0.000430284622981657 28 6812934 SGTC_135 0933-0004 26.348 µM 3.28132857746112 0.00054675853594471 yes 21 0.000516596533085378 50 21230617 YGL099W LSG1 SGTC_1727 st034309 9.9045 µM 3.2799802963846 0.000549315719702617 yes 22 0.000519071683635453 80 870305 SGTC_1173 0443-0020 122 µM 3.26777683744458 0.000572969342418582 yes 23 0.000541978992959194 75 5331295 SGTC_1115 galangin 695.678 nM 3.20583604843264 0.000708216853024314 yes 24 0.000673353477790714 35 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_234 nsc-17383 10.7 µM 3.18903338996734 0.0007496770152394 yes 25 0.000713746940980538 39 408974 SGTC_1737 st035557 69.7 µM 3.18565454707117 0.000758279659542436 yes 26 0.000722134702054317 34 5716916 SGTC_1703 st026983 48.3 µM 3.16286389012853 0.000818722123154503 yes 27 0.000781126772248604 36 1104023 SGTC_1972 st070201 17.4 µM 3.1215808541405 0.000939622967752658 yes 28 0.000899414223077401 53 2829099 SGTC_1237 0330-0133 46.1 µM 3.08367153754933 0.0010648732953881 no 29 0.00102231599581489 54 X1237 YHR072W ERG7 SGTC_3340 9146634 11.102 µM 3.08048841104766 0.00107605783930454 no 30 0.00103330698465141 49 4907387 SGTC_2342 7990637 118.86 µM 3.04411016764039 0.00121175444716073 no 31 0.0011668483176259 82 2033102 YER133W GLC7 SGTC_1923 st058458 19.1 µM 3.01028568499926 0.00135179752224429 no 32 0.00130501034499787 86 3534982 SGTC_194 1486-1323 56.904 µM 2.92659535233474 0.00176410604145661 no 33 0.00171347218447329 48 5178754 SGTC_2856 9022925 19.48 µM 2.92521483315709 0.00177177697029559 no 34 0.00172109249167763 82 4944862 SGTC_1698 5-fluorocytosine 1.055 µM 2.89644424361968 0.00193870743706441 no 35 0.00188708851402213 35 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1279 0874-0590 65.2 µM 2.88462222085304 0.00201134841018102 no 36 0.00195941804683192 81 3523074 SGTC_2770 toltrazuril 17.5 µM 2.83042845661141 0.00237699582750162 no 37 0.00232428531402551 82 68591 Kills coccidiodes. SGTC_67 0335-0847 266 µM 2.79708483417165 0.00263086044890753 no 38 0.00257829958210553 206 4552207 YOR254C SEC63 SGTC_3016 9080866 49.47 µM 2.77967129992823 0.00277295383581194 no 39 0.00272069729742705 90 17066299 SGTC_1339 1486-1321 22.7 µM 2.76121389684368 0.00293109266751329 no 40 0.00287934736491362 93 3469382 SGTC_1717 st033143 58.0435 µM 2.7449712138395 0.00307693196452755 no 41 0.00302581028510598 125 674616 SGTC_21 0849-0113 22.993 µM 2.6990405429963 0.00352535285135264 no 42 0.00347698520223419 117 1560156 SGTC_493 zm226600 134 µM 2.68890816494171 0.00363184898406256 no 43 0.00358430687881666 84 5240098 A potassium channel opener. YCR052W RSC6 SGTC_450 aminopyrene 156 nM 2.67815159221908 0.0037480566246175 no 44 0.00370148525085311 113 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2671 danthron 100 µM 2.67303831447606 0.00380445789836353 no 45 0.0037583832350595 118 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_594 1487-1584 10.8 µM 2.64563484765886 0.00411989193218083 no 46 0.00407688904909474 88 5013332 SGTC_803 4488-1585 147 µM 2.6311041347155 0.00429647412208849 no 47 0.00425539767852986 77 747204 SGTC_622 1348-1566 26.3 µM 2.60867443813472 0.00458234760128332 no 48 0.0045446835986728 101 7340407 SGTC_2175 5807670 165.306 µM 2.60234075199903 0.00466608899576412 no 49 0.00462949024379388 95 241186 SGTC_1805 st050013 60.3 µM 2.58343114810888 0.00492428591759005 no 50 0.00489114951613884 70 4037144 SGTC_349 k015-0014 24 µM 2.56662846323061 0.00516431627261968 no 51 0.00513462893596499 120 2196908 SGTC_2807 7945238 51.95 µM 2.56374501695369 0.00520653788078139 no 52 0.00517747926723034 141 17148797 SGTC_57 miconazole 162.5 nM 2.53866410660511 0.0055869408273486 no 53 0.00556383007141757 113 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2308 7584454 197.62 µM 2.5384989831915 0.00558952497881457 no 54 0.00556645632017098 139 893577 SGTC_1602 st001878 87.6 µM 2.52283543990795 0.00583953562390177 no 55 0.00582064317655375 102 595405 YLR310C CDC25 SGTC_935 2996-0153 430 µM 2.5084984387609 0.00607701718638923 no 56 0.0060622751977321 111 23738523 SGTC_1664 st014217 9.02 µM 2.47864722105725 0.00659911121422944 no 57 0.00659408364784093 95 3982782 SGTC_285 1486-1325 46 µM 2.44438268374726 0.00724694986796691 no 58 0.00725501315820623 108 22310230 SGTC_1971 st069429 63.5 µM 2.43247097668686 0.00748495768732408 no 59 0.00749809665336276 102 1246522 YGL099W LSG1 SGTC_3040 9091894 49.47 µM 2.4277423028999 0.0075813342965888 no 60 0.00759656714790936 95 25236966 SGTC_2982 9019404 25.97 µM 2.42267221396482 0.00768588181073679 no 61 0.00770341065465054 131 22333232 SGTC_1220 1838-0075 193 µM 2.42044265034805 0.00773225675030399 no 62 0.00775081213377506 113 5529645 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.41842720642425 0.00777438974080324 no 63 0.0077938820331017 130 94937 An inhibitor of serotonin biosynthesis. SGTC_1545 lovastatin 49.4 µM 2.39338065111195 0.00831509034859525 no 64 0.00834695577904112 161 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_631 k072-0230 41.5 µM 2.38001320742023 0.0086169650056402 no 65 0.00865600877507752 131 5773147 SGTC_2848 9016370 25.97 µM 2.36953981620055 0.00886015806353129 no 66 0.0089051186543412 145 7894410 SGTC_1229 0139-0193 12.2 µM 2.36893052992798 0.00887448907975265 no 67 0.00891980197371024 128 3090752 SGTC_250 brefeldin a 552.239 µM 2.36843414030613 0.00888617966687072 no 68 0.00893178024949743 94 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2139 5578692 56.4705 µM 2.35541216338208 0.00919772166441002 no 69 0.00925108534918126 104 650991 YMR113W FOL3 SGTC_2032 5185112 25.99 µM 2.33180494155149 0.00978694237997468 no 70 0.00985547748064314 109 5718189 SGTC_1916 st067606 49.2 µM 2.33102764897454 0.00980689137929188 no 71 0.00987595090012034 188 19590279 SGTC_1771 st048882 4.1505 µM 2.29769416706831 0.0106964810667495 no 72 0.0107896008893488 135 4580403 SGTC_1288 0973-0013 65.5 µM 2.28130492184911 0.0111590787413225 no 73 0.0112652048427229 145 4315430 SGTC_728 3030-5151 22.5 µM 2.2601664502131 0.0117813438023071 no 74 0.0119054611182484 126 3125388 SGTC_1041 0206-0046 107 µM 2.23928474975413 0.0124253954437108 no 75 0.0125686972557354 156 50494 SGTC_825 1988-2224 89.6 µM 2.22616097579653 0.0128455905555634 no 76 0.0130017004235799 189 1180859 SGTC_2350 9023895 38.85 µM 2.22593910881872 0.0128527986399179 no 77 0.0130091301577688 169 2997209 SGTC_1967 st070177 51.4 µM 2.21669864338833 0.0131561289122155 no 78 0.0133218457804376 141 5729214 SGTC_2369 9071472 200 µM 2.20609074657122 0.0135119555911788 no 79 0.0136888232457249 170 17296037 SGTC_639 0833-0042 114 µM 2.19733962635137 0.0138117233384178 no 80 0.0139980997952977 205 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1726 st035556 14.5795 µM 2.19253652839772 0.0139786775392199 no 81 0.0141703942485321 228 5919439 SGTC_1970 st070122 35.8 µM 2.19121357851008 0.0140249673395585 no 82 0.0142181702238541 182 102928 SGTC_3202 9113761 49.47 µM 2.19010182438946 0.0140639695441742 no 83 0.0142584264796704 234 4798415 SGTC_2765 myclobutanil 7.74 µM 2.18657805839392 0.0141882074683649 no 84 0.014386670282165 199 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3179 9107801 49.47 µM 2.17821872803103 0.0144867214006244 no 85 0.0146948782120012 148 4818259 SGTC_205 1486-1330 71.903 µM 2.17107811600255 0.0147459806284288 no 86 0.0149626339874827 118 4118834 SGTC_607 4491-0986 66.8 µM 2.16789901958685 0.0148626842200569 no 87 0.0150831852399535 185 698981 YDR232W HEM1 SGTC_1523 st012844 44.7 µM 2.15699727782413 0.0152689344516864 no 88 0.0155029382736547 192 4274103 SGTC_1162 k048-0130 20.1 µM 2.15352188439064 0.0154004329170423 no 89 0.0156388430328194 168 6797406 SGTC_2750 bromebric acid 70.15 µM 2.12623428374882 0.0164671100678573 no 90 0.0167418784010148 222 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_141 0443-0274 32.331 µM 2.11578374598005 0.0168920568529053 no 91 0.0171816020610639 313 1627241 SGTC_2493 resveratrol 26.09 µM 2.11456116368806 0.0169423776807591 no 92 0.0172336833090196 140 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_792 4534-1957 155 µM 2.11286540209639 0.0170123864520668 no 93 0.0173061449402006 197 1717904 SGTC_1573 oleylamine 1.06 µM 2.1077462236799 0.0172252314519337 no 94 0.017526473341227 223 5356789 An amine of the fatty acid oleic acid. SGTC_2433 5607874 27.82 µM 2.09797852295269 0.0176376688635634 no 95 0.0179535213190144 207 2252428 SGTC_229 benomyl 22.8748 µM 2.09524969199535 0.0177543879937266 no 96 0.0180744010071844 197 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2570 licareol 100 µM 2.09304772213905 0.0178490517467258 no 97 0.018172447361989 215 443158 SGTC_2786 7743617 45.45 µM 2.09174087769976 0.0179054369441875 no 98 0.0182308508397846 172 583674 SGTC_1374 2889-5571 141 µM 2.08750713681625 0.0180891505966498 no 99 0.0184211583019346 241 2853281 SGTC_1948 st076329 66.6 µM 2.0680528879009 0.0189541144219781 no 100 0.0193175250656573 194 24208413 SGTC_3060 1327-0027 12.5 µM 2.06790996285085 0.0189605970295388 no 101 0.0193242452006937 188 16000455 YPR107C YTH1 SGTC_593 1203-0218 61.7 µM 2.0653423982678 0.0190773748868943 no 102 0.0194453072932659 201 3666956 SGTC_84 0443-0269 128.823 µM 2.06193250790429 0.0192334083273875 no 103 0.0196070810336844 215 6150058 SGTC_1079 idarubicin 2.36 µM 2.0590886849907 0.019364367340053 no 104 0.0197428717871953 171 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_522 1273-0010 11.6 µM 2.05284907247732 0.0196543604452364 no 105 0.0200436087631465 204 5705015 SGTC_938 3126-1755 342 µM 2.04870816096474 0.0198488428080031 no 106 0.0202453303582019 184 1777771 SGTC_151 3013-0144 2.285 µM 2.04800305351223 0.0198821211323026 no 107 0.0202798501002016 212 906558 YHR107C CDC12 SGTC_1654 st012436 41.8 µM 2.0469345988383 0.0199326382524893 no 108 0.0203322532120058 162 4323132 SGTC_559 1550-0661 158 µM 2.04466391231 0.020040359299229 no 109 0.0204440018844999 185 5830875 SGTC_961 1252-1571 372 µM 2.03194558567457 0.0206528852658364 no 110 0.0210795824630342 223 6813498 SGTC_2407 paclitaxel 400 µM 2.0244541501755 0.0210210462830667 no 111 0.021461722491855 251 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_490 phenamil 164 µM 2.02052174435485 0.0212165141370178 no 112 0.0216646484948467 109 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2163 5671233 125 µM 2.01771734648759 0.0213568494155738 no 113 0.0218103535978362 232 701023 SGTC_2101 5377231 179.231 µM 2.0060852634243 0.0219473398754979 no 114 0.0224235759261989 177 2844213 SGTC_2678 equilin 100 µM 2.0004459829592 0.0222385375803416 no 115 0.0227260636336154 222 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2353 9059630 146.67 µM 1.99839154279739 0.0223454305408282 no 116 0.0228371139014054 171 4779114 SGTC_2204 7233102 200 µM 1.99819832014838 0.0223555062175979 no 117 0.0228475818000343 149 2172480 SGTC_353 1988-1175 58.3 µM 1.99386165724341 0.0225826535448792 no 118 0.0230835875957224 196 2788357 SGTC_2312 7706453 155.7 µM 1.98492500936066 0.0230568809994802 no 119 0.0235764077122472 238 976098 SGTC_2066 5222451 176 µM 1.98118607346539 0.0232577632811311 no 120 0.0237852052084804 286 2281147 SGTC_3307 9126885 69.2785 µM 1.97260813393353 0.0237242037186269 no 121 0.024270112790003 262 24824909 SGTC_1939 st074455 53.6 µM 1.971094359752 0.0238073289729241 no 122 0.0243565418828627 249 1644229 SGTC_1931 st074438 57.1 µM 1.95717474317879 0.0245832306627775 no 123 0.0251634635997259 204 2787313 SGTC_1687 st020778 55.3625 µM 1.94963306581013 0.0250124061703806 no 124 0.0256099346814817 426 4259299 SGTC_524 r073-0010 27.8 µM 1.93542829867989 0.0258378226219596 no 125 0.0264688797384932 259 2772106 SGTC_42 0133-0086 60.653 µM 1.93468304755535 0.0258817499781867 no 126 0.0265146009594097 218 162923 Model of phenazepam hydroxylation. SGTC_2345 9052315 157.45 µM 1.93461457809334 0.0258857889078093 no 127 0.0265188048746396 244 6469265 SGTC_1652 st011932 78 µM 1.92668417522614 0.026357174597859 no 128 0.0270095005953704 211 1551076 SGTC_2663 amphotericin b 100 µM 1.92623739715683 0.0263839433452912 no 129 0.0270373691196806 222 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_977 1348-1378 135 µM 1.92160550923243 0.026662804584387 no 130 0.027327707428653 239 X977 SGTC_2421 5690543 90.72 µM 1.91581364728848 0.0270149613386443 no 131 0.0276944100010422 251 3397993 SGTC_1886 st057356 49.9 µM 1.9052438508144 0.0276676326864868 no 132 0.0283741902456242 241 24207747 SGTC_452 diindolylmethane 8 µM 1.90086053909989 0.027942125272444 no 133 0.0286601409844317 199 3071 Inhibits expression of several cancer promoting factors. SGTC_1418 3966-3099 2.4 µM 1.89268861743528 0.028459925634083 no 134 0.0291996455054735 266 740335 SGTC_1500 4488-1866 171 µM 1.88907575499807 0.028691380557882 no 135 0.029440839315778 263 2900003 SGTC_1258 0671-0043 57.1 µM 1.88533434528836 0.0289327184338246 no 136 0.0296923559826731 281 4298767 SGTC_352 k048-0007 5.11 µM 1.87863025475335 0.0293693825581303 no 137 0.0301474985409704 318 6811911 SGTC_2837 9008476 45.46 µM 1.8771139875007 0.0294688982104919 no 138 0.0302512363548733 293 2992805 SGTC_1166 k206-0078 225 µM 1.8719398732522 0.0298105954011902 no 139 0.0306074611962361 290 5404595 SGTC_2687 chenodiol 100 µM 1.87142821302545 0.0298445631799247 no 140 0.0306428757089768 237 5702181 A cholesterol synthesis inhibitor. SGTC_345 1362-0200 395 µM 1.86465411673743 0.0302973118258843 no 141 0.0311149510424529 244 1419823 SGTC_3306 9127676 59.7925 µM 1.86087562117397 0.0305523119031433 no 142 0.0313808716158316 265 41905287 SGTC_644 1498-1197 63.3 µM 1.8590690508622 0.0306748589834811 no 143 0.031508675729181 293 6741615 SGTC_1811 st050069 61.5 µM 1.84873297642926 0.0313838474207328 no 144 0.0322481897617686 196 3877702 SGTC_2855 9016525 58.44 µM 1.84838500266319 0.0314079499905861 no 145 0.0322733333620488 267 43811474 SGTC_256 clotrimazole 625 nM 1.84694706084254 0.0315077120677213 no 146 0.0323774066009249 284 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_897 1000-0139 31.4 µM 1.8437159854963 0.0317328346229288 no 147 0.0326122710612559 242 6151020 SGTC_1861 st057647 17.4 µM 1.84233148895728 0.0318297042106677 no 148 0.0327133382219308 258 688668 SGTC_61 0978-8327 98.565 µM 1.84226888726783 0.031834090052515 no 149 0.0327179141921288 288 6150059 YHR072W ERG7 SGTC_99 0109-0120 622.8 µM 1.83997280665307 0.0319952975275452 no 150 0.0328861148860261 223 759414 SGTC_3354 9151612 71.43 µM 1.83760259286945 0.0321624164110407 no 151 0.0330604932346371 266 27261949 SGTC_1183 1254-0324 198 µM 1.83687140576891 0.0322141161031939 no 152 0.0331144407158064 246 5799357 SGTC_2935 9038016 29.96 µM 1.83564046109188 0.0323013068462638 no 153 0.0332054244616714 278 6463195 SGTC_115 0527-0192 112.043 µM 1.83097185487844 0.0326337671491141 no 154 0.0335523720503508 392 4233931 SGTC_1974 st069448 26.9 µM 1.82553538466904 0.0330244596055295 no 155 0.033960138251228 244 6323587 YNR016C ACC1 SGTC_435 c-PAF 6.7 µM 1.8252425169112 0.0330456155179888 no 156 0.0339822201946097 308 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_571 k831-0106 44.2 µM 1.80455323722615 0.0345686496144034 no 157 0.0355723106444437 252 4783639 SGTC_2082 5219693 150 µM 1.80407461248717 0.034604554582725 no 158 0.0356098055091728 302 2834649 SGTC_1697 st025554 27.742 µM 1.79896251102324 0.0349899629555818 no 159 0.0360123055473677 246 1269519 SGTC_1524 corynanthine 62.1 µM 1.78917358857189 0.0357377944538883 no 160 0.036793431888088 280 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_276 colchicine 750 µM 1.78802549617966 0.0358263556619869 no 161 0.0368859472292115 313 2833 A microtubule depolymerizer. SGTC_608 k048-0125 159 µM 1.78768062319809 0.0358529934639507 no 162 0.0369137748303835 296 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_635 k038-0028 24.7 µM 1.78385337877822 0.0361496984163745 no 163 0.0372237466108163 316 4035102 SGTC_2112 5488546 200 µM 1.7733340345996 0.0369755745432486 no 164 0.0380866862957407 321 600757 SGTC_1458 k015-0034 6.33 µM 1.7599726737301 0.0380467488796138 no 165 0.0392062199649214 290 3598957 SGTC_2598 perillyl alcohol 100 µM 1.75621678693435 0.0383523732889754 no 166 0.0395256997034646 319 10819 An apoptosis inducer. SGTC_1913 st060213 96.1 µM 1.75352665636188 0.0385725026929921 no 167 0.0397558240328698 344 688959 SGTC_2341 7987486 176.74 µM 1.75273828383469 0.0386372087790758 no 168 0.0398234705263502 335 1258686 SGTC_2015 5119600 184 µM 1.73634706207313 0.0400026784622148 no 169 0.041251243266983 315 2828786 SGTC_3090 9117696 49.47 µM 1.73478792663955 0.0401345796096162 no 170 0.0413891877275162 275 7923821 SGTC_2466 5983409 37.09 µM 1.72619095316145 0.040868232845171 no 171 0.0421565325378185 292 2879657 SGTC_3312 9133330 71.43 µM 1.71808333434253 0.0415700577735677 no 172 0.0428907080910297 303 17617324 SGTC_11 0438-0307 1.3 µM 1.71626287958074 0.0417289777932855 no 173 0.0430569695518154 285 4011476 SGTC_432 NS 1619 61.3 µM 1.71195777457126 0.0421067581893263 no 174 0.0434522251603611 300 4552 A K+/calcium channel activator. SGTC_2999 9069765 71.4286 µM 1.70061213753229 0.0431156292465703 no 175 0.0445079217367568 327 2097066 SGTC_185 k048-0037 25.491 µM 1.69595820161633 0.0435350718563791 no 176 0.044946898061956 311 6827589 SGTC_2431 5490079 200 µM 1.69538189618354 0.0435872406018403 no 177 0.0450014989867804 330 5722345 SGTC_340 k038-0059 454 µM 1.6922842446862 0.0438685134901792 no 178 0.045295895193115 349 23733424 SGTC_2525 harmine 47.85 µM 1.69166529403773 0.0439248905535324 no 179 0.0453549046506416 243 5280953 A monoamine oxidase inhibitor SGTC_125 0133-0007 11.75 µM 1.68950346346933 0.044122259316533 no 180 0.0455614943473896 303 26541 SGTC_540 1187-0821 17.3 µM 1.68925005692882 0.0441454413313656 no 181 0.0455857599454936 325 847520 SGTC_97 0535-0701 19.132 µM 1.687641785136 0.0442927974839529 no 182 0.0457400064980751 292 2832013 YGL099W LSG1 SGTC_2843 9000894 45.46 µM 1.68365462250912 0.0446598269820673 no 183 0.0461242178853582 200 2242070 SGTC_817 1391-0715 46 µM 1.68083128006134 0.0449212019513357 no 184 0.046397845504618 303 1353946 SGTC_227 fluconazole 33.516 µM 1.68049539312151 0.0449523789637543 no 185 0.0464304849476063 410 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_592 k241-0073 46.5 µM 1.67885473517413 0.0451049151768557 no 186 0.0465901790520819 342 4230158 SGTC_2048 5246248 200 µM 1.67796981335664 0.045187361404896 no 187 0.0466764960847293 268 677046 SGTC_822 1487-0950 154 µM 1.67635738340137 0.0453378997042101 no 188 0.046834105576795 321 1958375 SGTC_1493 4348-0038 111 µM 1.67336884716458 0.0456179794134186 no 189 0.0471273533531385 364 800424 SGTC_2010 4012422 159 µM 1.66984418567058 0.0459500896145266 no 190 0.0474750978143827 342 952393 SGTC_1684 st024538 14.6195 µM 1.66804810513126 0.0461200704253401 no 191 0.047653088848737 339 6732859 SGTC_1656 st012921 11 µM 1.66641649307519 0.046274923413793 no 192 0.0478152440146561 290 6732821 SGTC_137 0438-0332 85.389 µM 1.66009940859533 0.0468784062778005 no 193 0.0484472279421202 513 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_865 0488-0499 301 µM 1.65554987076034 0.0473169297204016 no 194 0.0489065045401933 357 9634651 SGTC_1403 3909-7815 62.9 µM 1.64629664655777 0.0482189754215734 no 195 0.0498513497850458 287 6615483 SGTC_2634 4'-methoxyflavone 100 µM 1.64509494443421 0.0483371254858909 no 196 0.0499751165059795 342 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1521 st012942 49.4 µM 1.64325337815473 0.0485186355304856 no 197 0.0501652600151541 390 24207259 SGTC_916 4466-0038 42 nM 1.64304792865266 0.0485389189695823 no 198 0.050186508587441 469 5722064 YGL116W CDC20 SGTC_1407 3909-7909 12.3 µM 1.63897389769424 0.04894253836304 no 199 0.0506093479818796 367 4411780 SGTC_747 3448-8087 38.7 µM 1.63223556707131 0.0496159943735494 no 200 0.0513149354238967 384 5168703 SGTC_421 streptovitacin 30 mM 1.6272333219073 0.0501207053466726 no 201 0.0518437765917833 396 91467 include heat shock SGTC_1002 4049-0206 172 µM 1.62068719315827 0.0507873629043216 no 202 0.0525423708087264 403 4662749 SGTC_1236 0330-0013 258 µM 1.61364329567728 0.0515125796978735 no 203 0.0533024100061929 319 4617066 SGTC_2751 anetholtrithion 17.25 µM 1.6092597742691 0.0519680340169017 no 204 0.0537797754729799 378 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1255 0566-0045 221 µM 1.60174597613 0.0527561655430206 no 205 0.0546058969241149 388 2788469 SGTC_1759 st043059 70 µM 1.59758730715267 0.0531964331090069 no 206 0.0550674265527763 415 669426 SGTC_2771 fluoxetine 41.05 µM 1.59657223513623 0.0533043372038376 no 207 0.0551805460182445 336 3386 A selective serotonin reuptake inhibitor. SGTC_1010 4112-3296 15.2 µM 1.59061199459422 0.0539414262215933 no 208 0.0558484617062108 415 704384 SGTC_937 3122-0005 46.7 µM 1.59005510301978 0.0540012589002843 no 209 0.0559111924493961 389 759535 SGTC_1969 st069479 40.1 µM 1.58985229719004 0.0540230614945402 no 210 0.0559340512022881 331 3895485 SGTC_1164 k060-0068 93.7 µM 1.58896706476137 0.0541183098010905 no 211 0.0560339142966339 407 5963676 SGTC_1579 chlormadinone acetate 49.4 µM 1.57858191070941 0.0552456729681328 no 212 0.0572159932607179 386 45114258 A steroidal progestin. SGTC_646 4092-0839 27.3 µM 1.5732915045416 0.0558270632751851 no 213 0.0578256677837095 366 877796 SGTC_1866 st057638 64 µM 1.57259191038742 0.0559043053934743 no 214 0.0579066710174404 362 688802 SGTC_765 1319-0117 244 µM 1.56280511137117 0.0569937268648599 no 215 0.0590492207953577 354 3487746 YGL099W LSG1 SGTC_862 0452-0056 10.2 µM 1.56263471672299 0.0570128414084609 no 216 0.0590692688457177 357 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3299 9121982 43.1275 µM 1.5614242150281 0.0571487784834962 no 217 0.0592118460596504 396 17594604 YPL160W CDC60 SGTC_1705 st027868 56.3335 µM 1.55919633236433 0.0573996322612931 no 218 0.0594749593295953 339 292948 SGTC_1806 st050005 60.3 µM 1.55373361876066 0.0580183861306264 no 219 0.0601239851934845 384 5194765 SGTC_489 paxilline 115 µM 1.55315714602173 0.0580839869994929 no 220 0.0601927982333371 362 105008 A toxic potassium channel blocker. SGTC_2470 5664817 21.68 µM 1.55245613503372 0.0581638384655691 no 221 0.0602765603490885 343 2859561 SGTC_2764 methyldopa 94.69 µM 1.55239185318004 0.0581711650627585 no 222 0.0602842457974402 417 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2647 atorvastatin 60.16 µM 1.54731601406116 0.058751982144053 no 223 0.060893531016445 379 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1273 0849-0096 14.1 µM 1.54682829859058 0.058808029186983 no 224 0.0609523272346076 412 5286025 SGTC_2581 avocatin a 64 µM 1.54489596096938 0.0590305011466866 no 225 0.06118571529713 443 6710728 A skin care supplement. SGTC_1456 k015-0012 13 µM 1.54315781369503 0.0592311793166764 no 226 0.0613962450878427 446 2989616 SGTC_821 1114-0266 29.2 µM 1.53814431198354 0.0598130120245312 no 227 0.0620066667397402 381 3123235 SGTC_1080 nisoldipine 24.4 µM 1.53308574538176 0.0604046029124467 no 228 0.0626273647070266 424 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1430 4049-0248 69.1 µM 1.52782856491497 0.061024263292155 no 229 0.063277554032066 448 22774488 SGTC_1605 st000082 49.1 µM 1.52760274932799 0.0610509909152901 no 230 0.063305599374821 375 1114022 SGTC_2711 st079103 59.1 µM 1.52730398105009 0.0610863673087814 no 231 0.0633427200041977 346 54693780 SGTC_2320 7373003 200 µM 1.52516982113989 0.0613395339461752 no 232 0.0636083728973006 397 5415828 SGTC_658 3253-0951 102 µM 1.52196762120238 0.0617209345551493 no 233 0.0640085969573061 531 1184878 SGTC_3127 9126946 49.47 µM 1.52188484089823 0.0617308186641807 no 234 0.0640189690821206 362 27243249 SGTC_2054 5233173 129 µM 1.52120379231896 0.0618121839335247 no 235 0.0641043520445145 478 6889 SGTC_1227 3909-8010 46.6 µM 1.51964361023806 0.0619988953360702 no 236 0.0643002855406232 391 15982272 SGTC_1050 3232-1156 69.3 µM 1.51862038124047 0.0621215868118488 no 237 0.0644290389607864 426 700529 SGTC_813 k007-0158 173 µM 1.51459633323754 0.062605933081725 no 238 0.0649373306784973 479 6523916 SGTC_1073 triclabendazole 3.09 µM 1.51146428206249 0.0629849491425411 no 239 0.0653351011102491 478 50248 An antihelmetic and likely tubulin inhibitor. SGTC_693 4161-2696 114 µM 1.50555894711857 0.06370442545296 no 240 0.0660902169168646 347 805759 SGTC_2988 9073640 71.4286 µM 1.50413877560327 0.0638784021049267 no 241 0.0662728190141941 402 9102229 SGTC_952 1185-0122 232 µM 1.50386168282347 0.0639123901140737 no 242 0.0663084924216262 429 678600 SGTC_3310 9130229 44.1445 µM 1.50309471265903 0.064006539484197 no 243 0.0664073110421388 399 7761258 SGTC_1348 1493-0373 93.8 µM 1.49813202610508 0.0646183423613361 no 244 0.0670494758791756 399 3010129 SGTC_1176 0848-0131 83.3 µM 1.49329893582152 0.0652185248590946 no 245 0.0676794770155938 465 6769040 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.49219246820172 0.0653565347070429 no 246 0.0678243481413686 499 688788 SGTC_3183 9108214 49.47 µM 1.49138628907727 0.0654572321135969 no 247 0.0679300528756277 271 4974831 SGTC_2593 nobiletin 86.24 µM 1.49136552881773 0.0654598268034037 no 248 0.067932776602118 381 72344 An anti-infammatory. SGTC_546 peri-Naphthalide 147 µM 1.48512660757496 0.0662432092483947 no 249 0.0687551444726706 429 223824 A penicillin ester. SGTC_2122 5258151 111.688 µM 1.4826033225283 0.066562096933663 no 250 0.0690899169369319 430 2173356 SGTC_1106 tegaserod maleate 11.7 µM 1.48161874205936 0.0666868480303072 no 251 0.0692208846188283 454 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_795 0685-0265 78 µM 1.47759862186777 0.0671980951071572 no 252 0.0697576217286967 465 302754 SGTC_204 PMA1.184 62.41 µM 1.47731192323097 0.067234670620057 no 253 0.0697960216744811 487 2252213 YGL008C PMA1 SGTC_2697 mebhydrolin 72.4 µM 1.47512884262962 0.0675136816362475 no 254 0.0700889537241194 508 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.46923158642394 0.0682718602737057 no 255 0.070884992850298 523 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2034 5197015 53.07 µM 1.46736723142912 0.0685129124504449 no 256 0.0711380917909497 441 780676 SGTC_12 0849-0099 9.267 µM 1.46509323921764 0.0688078169151805 no 257 0.0714477404857592 408 6071388 SGTC_801 0866-0028 10.1 µM 1.45750771282774 0.0697986323709111 no 258 0.0724881419453371 478 6849771 SGTC_1649 st011737 51.3 µM 1.45233640946876 0.0704803741481605 no 259 0.0732040442025068 437 1761035 SGTC_444 curcumin 90.4 µM 1.45106866764836 0.0706482814446089 no 260 0.0733803700894638 464 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_700 3453-2283 142 µM 1.4507176623034 0.0706948249867941 no 261 0.0734292476025449 514 565664 SGTC_601 0986-0029 62.9 µM 1.44915353481014 0.070902515831443 no 262 0.0736473551753678 496 24747981 SGTC_2420 aureobasidin a 50 nM 1.4382384540658 0.0723649327529445 no 263 0.0751832039478887 506 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.43813961027496 0.0723782807763688 no 264 0.0751972228750249 492 1377 SGTC_997 3996-0078 137 µM 1.43750914608536 0.0724634640624364 no 265 0.0752866879540083 470 735687 SGTC_199 4063-0024 41.6 µM 1.43568945112531 0.0727097574688249 no 266 0.0755453641323688 436 306215 SGTC_393 acivicin 6.25 µM 1.43539567318637 0.0727495799686281 no 267 0.075587189139566 413 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2127 5253358 187.912 µM 1.43069738162285 0.0733887192297498 no 268 0.0762584819933166 409 20612 SGTC_2046 4110841 106 µM 1.42864328024251 0.0736694976747986 no 269 0.0765533939233597 450 44119630 YMR134W ERG29 SGTC_3069 9117009 49.47 µM 1.42377471991022 0.0743382683160042 no 270 0.07725584796986 338 41904981 SGTC_2346 9031566 143.75 µM 1.42338109229222 0.074392540942738 no 271 0.0773128552953221 439 4771086 SGTC_2445 5742597 35.57 µM 1.42287412110303 0.0744624857325807 no 272 0.0773863247370697 455 1774255 SGTC_1834 st055981 52.8 µM 1.41635372821175 0.0753665591002751 no 273 0.0783359821773073 474 471719 YDL150W RPC53 SGTC_1941 st076221 61.8 µM 1.41378322013903 0.0757252587840354 no 274 0.0787127809183392 544 2828568 SGTC_2588 indole-3-carbinol 100 µM 1.41105801399967 0.0761069643313148 no 275 0.0791137543326456 522 3712 Induces cell cycle arrest. SGTC_2474 5321570 43.32 µM 1.41072239723537 0.0761540735531366 no 276 0.0791632421146963 443 2841384 SGTC_1980 st071811 45.7 µM 1.41016338708729 0.0762325889056328 no 277 0.0792457220067235 458 4974850 SGTC_2435 5706476 10.6 µM 1.40959085867742 0.0763130668010237 no 278 0.0793302638913752 497 5725375 SGTC_732 3970-1727 52.7 µM 1.40672779581458 0.0767164857407385 no 279 0.0797540601081531 437 1275699 SGTC_3343 9148379 18.9835 µM 1.40314435317438 0.0772236921519171 no 280 0.0802868987005616 460 1955036 SGTC_1168 k815-0004 80.5 µM 1.39719962332172 0.078070732361214 no 281 0.0811767749876091 486 642433 SGTC_2195 6536160 144.242 µM 1.39713733571058 0.0780796446311343 no 282 0.0811861381597289 418 3834386 SGTC_1991 st073000 8.92 µM 1.39296404258923 0.0786785298859915 no 283 0.081815332176103 543 4301969 YIL048W NEO1 SGTC_424 splitomicin 100 mM 1.39171391395596 0.078858604517872 no 284 0.08200452360321 468 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2380 9035439 200 µM 1.3908399329392 0.0789846823415602 no 285 0.0821369854179417 545 6462575 SGTC_547 1120-0019 610 nM 1.38919974229419 0.0792217032540227 no 286 0.0823860100356352 485 3676939 SGTC_2800 7887935 81.82 µM 1.38692711560357 0.0795510058156793 no 287 0.082731994266602 465 2961002 SGTC_1004 4084-0029 199 µM 1.38579008585496 0.0797161491482534 no 288 0.082905505282415 541 716894 YLR208W SEC13 SGTC_1699 st031318 29.054 µM 1.38491081276159 0.0798440333641579 no 289 0.0830398701643165 469 5340658 SGTC_959 1222-0044 107 µM 1.38329473917655 0.0800794847120274 no 290 0.0832872552298732 490 6083612 SGTC_321 4534-3890 65.3 µM 1.38296321421373 0.0801278505488261 no 291 0.0833380727763135 482 699746 SGTC_2898 9056270 58.44 µM 1.38239822547494 0.0802103270543168 no 292 0.0834247303390957 407 19154699 SGTC_500 h-89 112 µM 1.38088526323413 0.0804315037676888 no 293 0.0836571208877222 533 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1315 1237-0019 3.69 µM 1.37992181551018 0.0805725880773621 no 294 0.0838053594326137 498 825140 SGTC_976 1348-1067 47.6 µM 1.37602646107518 0.08114491793399 no 295 0.0844067205552868 556 5310671 YGL099W LSG1 SGTC_883 0850-0245 24.6 µM 1.37440814946837 0.0813835903582092 no 296 0.0846575037782438 525 6823229 YPR165W RHO1 SGTC_2205 7238770 200 µM 1.37081684412262 0.0819151354074776 no 297 0.0852160293646363 447 279867 SGTC_86 0417-1630 471.922 µM 1.37062016030521 0.0819443217437577 no 298 0.0852466975041123 635 3634867 SGTC_1559 coumarin 343 70.1 µM 1.36116372275132 0.0833568464221841 no 299 0.0867309778310762 445 108770 A hepatotoxic, DNA x-linker. SGTC_402 epigallocatechin gallate 10 µM 1.36060759511736 0.0834404825075014 no 300 0.086818865052235 537 65064 An antioxidant. SGTC_2515 chrysin 20.77 µM 1.35994302188906 0.0835405104347282 no 301 0.0869239776460497 500 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1169 aniline yellow 25.8 µM 1.35905827108837 0.0836738180863435 no 302 0.0870640622445028 461 6051 A DNA damaging agent. SGTC_1372 2752-0194 270 µM 1.35768351567398 0.083881272976878 no 303 0.0872820648261609 474 823334 SGTC_264 promethazine 12.5 mM 1.34823278434197 0.0853178847267057 no 304 0.0887917615836115 627 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_365 0121-0052 13.6 µM 1.34456276501133 0.0858807082410355 no 305 0.0893832373112754 579 3101739 SGTC_842 0271-0008 11.1 µM 1.34453051687138 0.0858856660079456 no 306 0.0893884475152082 558 1221709 SGTC_1789 tunicamycin 25 nM 1.33329269412889 0.0876264203225461 no 307 0.091217885145404 505 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_663 1486-0733 13.9 µM 1.33048705274363 0.0880650967929777 no 308 0.0916789247054287 585 722445 YPR165W RHO1 SGTC_198 3454-2873 16.191 µM 1.33039183084951 0.0880800139026943 no 309 0.0916946023660482 520 710957 SGTC_2994 9053520 71.4286 µM 1.32550656560309 0.0888478513605689 no 310 0.0925015966220952 532 4647384 SGTC_931 2812-0076 566 µM 1.32464680600167 0.0889834975305993 no 311 0.0926441619299395 554 3450959 SGTC_2461 5755302 26.15 µM 1.32154066722932 0.0894748445002497 no 312 0.0931605760139765 576 2788904 SGTC_2235 salicylic acid 500 µM 1.32070309074691 0.0896076819685033 no 313 0.0933001915621641 507 338 A COX inhibitor and kinase inhibitor. SGTC_1103 duloxetine 36.1 µM 1.31891141000417 0.0898923301735201 no 314 0.0935993655782395 600 60835 A selective serotonin reuptake inhibitor. SGTC_193 1273-0060 1.558 µM 1.31852565009577 0.089953704512738 no 315 0.0936638721668517 434 2847393 YHR072W ERG7 SGTC_116 0155-0182 31.788 µM 1.31840880197635 0.0899723011730424 no 316 0.0936834179295486 664 771486 SGTC_1202 1988-0068 29.6 µM 1.31592197288665 0.0903687637291377 no 317 0.0941001164747621 551 2850480 SGTC_1186 1319-0216 26 µM 1.31196704776767 0.0910019473212138 no 318 0.0947656265645281 576 4565136 SGTC_2544 sphondin 68.51 µM 1.31158278880408 0.0910636421576099 no 319 0.0948304716719095 499 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1343 1487-0095 224 µM 1.31042575587629 0.0912495973298858 no 320 0.0950259226491658 507 4560101 YGL055W OLE1 SGTC_798 1287-0182 476 µM 1.30802044605283 0.0916370729347664 no 321 0.0954331872397137 589 1649755 SGTC_211 3455-0679 143.504 µM 1.30658036264713 0.091869641222307 no 322 0.0956776347651461 561 748649 SGTC_2743 auranofin 4.32 µM 1.30644041138132 0.0918922661340904 no 323 0.0957014153867886 504 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2176 5809774 33.9695 µM 1.30213385955806 0.0925904940500783 no 324 0.0964353150822873 560 2870539 SGTC_2089 5281248 129.67 µM 1.30022805646028 0.0929007344933041 no 325 0.0967614086642153 553 2737878 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.29966303231797 0.0929928607580138 no 326 0.0968582429115762 558 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_422 cantharidin 155 µM 1.29814055743162 0.0932414339254194 no 327 0.0971195198995617 557 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2954 9074818 52.69 µM 1.29716797405191 0.093400483564989 no 328 0.097286698717619 544 16648742 SGTC_3095 9117207 49.47 µM 1.2968581153021 0.0934511978191662 no 329 0.0973400051282442 476 17015229 SGTC_2199 6590217 200 µM 1.29479611954439 0.0937892006071544 no 330 0.0976952854921293 463 703109 SGTC_2191 5911152 200 µM 1.288325564284 0.094855713782727 no 331 0.0988163288865131 533 2875902 SGTC_662 k832-1615 104 µM 1.28798624017376 0.0949118886726898 no 332 0.0988753765151789 542 5878478 SGTC_1189 1431-2119 7.28 µM 1.28770819644035 0.0949579369022935 no 333 0.0989237796536364 578 3107275 SGTC_3240 9133527 49.47 µM 1.2858389602044 0.095267937895068 no 334 0.0992496350253188 558 17617455 SGTC_1201 1889-3372 45.9 µM 1.28462651917949 0.0954694115858261 no 335 0.0994614135198883 532 5392199 SGTC_2685 mycophenolic acid 18.85 µM 1.28402991622031 0.0955686653121002 no 336 0.0995657440280492 503 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1256 0570-0116 285 µM 1.28243253565768 0.0958347870042363 no 337 0.0998454784791436 526 410638 SGTC_2866 9034245 58.44 µM 1.28196558039776 0.0959126840575519 no 338 0.0999273603582751 489 6462273 SGTC_3297 9117502 71.43 µM 1.2816340340939 0.0959680205744104 no 339 0.0999855276719641 527 7453720 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.28066145763096 0.0961304832550623 no 340 0.100156301564598 573 4213774 SGTC_2167 5876490 200 µM 1.27819274482699 0.0965437737909868 no 341 0.100590736825421 561 686534 SGTC_1983 st071813 46.9 µM 1.27739759832671 0.0966771678739867 no 342 0.100730956122947 562 11838595 SGTC_2080 5212524 12.4 µM 1.27635798067668 0.0968517786676946 no 343 0.100914501391258 539 260183 SGTC_1454 4239-0054 42.6 µM 1.27456818490124 0.0971529292355835 no 344 0.101231062187723 619 1340767 SGTC_1606 st000094 49.2 µM 1.27376118423937 0.097288939511322 no 345 0.101374032664156 590 1242210 SGTC_1552 6-methylflavone 10.6 µM 1.27336223242262 0.09735622963247 no 346 0.101444766384439 496 689013 SGTC_1382 3002-2117 298 µM 1.27272079955444 0.0974644899432584 no 347 0.101558567082649 599 1497314 SGTC_405 ebelactone b 50 µM 1.27076461731533 0.0977951973922315 no 348 0.101906199907768 589 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_694 1315-0438 43.2 µM 1.26717911725698 0.0984034876405709 no 349 0.102545625475769 477 6793154 SGTC_2970 9090938 41.86 µM 1.26580063713671 0.0986380865622511 no 350 0.102792233472755 651 17217104 SGTC_56 0957-0365 83.25 µM 1.26279762260332 0.0991505764257578 no 351 0.103330959667507 583 6752360 SGTC_1917 st066507 28.5 µM 1.25170819015068 0.101059953690467 no 352 0.105338107309104 626 3156428 SGTC_946 3434-1334 87.4 µM 1.25078733028721 0.101219704195872 no 353 0.105506039265483 560 4047976 SGTC_1624 st003710 6.25 µM 1.24893115542065 0.101542271998361 no 354 0.105845127587316 642 24207033 SGTC_3212 9128307 49.47 µM 1.24545811234306 0.10214783026926 no 355 0.106481701780056 511 27243542 SGTC_554 4483-2211 187 µM 1.24392102609552 0.102416673012159 no 356 0.106764315018744 567 747107 SGTC_302 1094-0063 18.9 µM 1.24180040762423 0.102788422000612 no 357 0.107155106157373 515 5440289 SGTC_1891 st059073 26.2 µM 1.23803687198303 0.103450590463323 no 358 0.107851194646599 631 688754 SGTC_971 1315-0384 26.7 µM 1.23531127527419 0.103932070041583 no 359 0.108357339503768 588 6769120 SGTC_1066 ketoconazole 628 nM 1.22970362376242 0.104927774752203 no 360 0.109404054669514 632 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2958 9077254 16.72 µM 1.22507264812656 0.105755251161682 no 361 0.110273924818629 552 16457351 SGTC_3336 9143619 71.43 µM 1.2247903752002 0.10580584062591 no 362 0.110327106143115 645 45595730 SGTC_2543 pimpinellin 60.67 µM 1.22431270573342 0.10589148925464 no 363 0.110417142831422 573 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2178 5812956 200 µM 1.22211505873172 0.106286184439137 no 364 0.110832059618935 577 5403383 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.21954689489133 0.106748769083148 no 365 0.111318344160062 640 688751 SGTC_864 0469-0573 172 µM 1.21279885251027 0.107971164738825 no 366 0.112603367127396 593 689425 SGTC_1719 st032227 49.2 µM 1.20920698128658 0.108625921316468 no 367 0.11329166814176 597 3125804 SGTC_1678 st019265 80.2 µM 1.20889385955016 0.108683134827332 no 368 0.113351812765547 646 5367020 SGTC_2246 7293507 91.5585 µM 1.20711418814861 0.10900872751714 no 369 0.11369408577332 635 887656 SGTC_309 k408-0051 1.48 µM 1.20552030548089 0.109300924584113 no 370 0.114001252017475 697 3640463 SGTC_3287 9117173 37.0625 µM 1.20386455679688 0.109605058595277 no 371 0.114320966435638 555 2789709 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.20345320727407 0.109680710930369 no 372 0.114400494294909 592 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_16 erodoxin 22.806 µM 1.19634161438897 0.110994552631451 no 373 0.115781637752332 676 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2933 9026794 32.47 µM 1.19609636241337 0.111040062284585 no 374 0.115829478497589 638 17586027 SGTC_15 0266-0086 27.098 µM 1.19535858798152 0.111177046368771 no 375 0.115973479103756 735 1712902 YIL048W NEO1 SGTC_2467 5474540 200 µM 1.18919668232729 0.112325867205186 no 376 0.117181139876941 622 5413519 SGTC_3277 9138724 49.47 µM 1.18834259310417 0.112485769874655 no 377 0.117349231720627 508 15943418 SGTC_2899 9053889 58.44 µM 1.18737309953976 0.112667475532655 no 378 0.117540242944101 605 6470052 SGTC_1437 4092-1038 11.6 µM 1.18541693934776 0.113034743419113 no 379 0.117926318737322 671 3977136 SGTC_568 1193-0097 7.48 µM 1.18257653514913 0.11356954734838 no 380 0.118488508309167 652 3646150 SGTC_294 k038-0071 157 µM 1.18170047464254 0.113734859360304 no 381 0.118662284970139 652 24152826 SGTC_3029 9088683 49.47 µM 1.17968301461997 0.114116204773257 no 382 0.119063155946298 628 25236615 SGTC_403 arphamenine a 50 µM 1.17910511807277 0.114225607861447 no 383 0.119178160434902 632 5487158 An arginine aminopeptidase inhibitor. SGTC_293 4049-0273 38.5 µM 1.17809361590624 0.114417277696223 no 384 0.119379643442431 602 1380311 SGTC_2626 ethyl orsellinate 100 µM 1.1775983662173 0.114511206153563 no 385 0.119478380757342 600 75653 A natural product. SGTC_1200 1643-0193 18.4 µM 1.17011172082738 0.115937804425639 no 386 0.120978006146728 682 5403974 SGTC_2891 9063876 19.48 µM 1.16925757743035 0.116101361936554 no 387 0.121149934782205 576 6472478 SGTC_3324 9138759 60.749 µM 1.16730747728405 0.116475394736621 no 388 0.121543110055337 637 45595710 SGTC_1402 3909-7673 35.9 µM 1.16470585857932 0.116975719591353 no 389 0.122069038360986 635 5328014 SGTC_3117 9124945 49.47 µM 1.16414083238529 0.117084582434135 no 390 0.122183471727182 562 17592065 SGTC_2902 5787006 60.46 µM 1.1585714293955 0.118161473998967 no 391 0.123315460148465 631 591003 SGTC_1989 st071868 50.2 µM 1.15602952530167 0.118655293761138 no 392 0.123834540184416 662 16414057 SGTC_672 1441-0018 53.7 µM 1.15268966696047 0.119306347468398 no 393 0.124518892081686 621 251141 SGTC_2485 5633444 17.78 µM 1.15169886465163 0.119499973029047 no 394 0.124722419492972 643 5724239 SGTC_2717 st081029 62.2815 µM 1.15097160137902 0.119642238012119 no 395 0.124871959447606 645 5292846 SGTC_453 enantio-paf c16 10 µM 1.14582025122554 0.120653349224227 no 396 0.125934767023976 810 13871343 A lipid and platelet activating factor SGTC_633 0437-0093 97.7 µM 1.1402461171484 0.121754204973166 no 397 0.127091889635605 654 2831118 SGTC_2102 5377816 72.7585 µM 1.13870958543239 0.122058897118355 no 398 0.127412151706589 705 1379702 SGTC_1882 5615643 20 µM 1.13776846622794 0.12224578398413 no 399 0.127608587818415 626 2253075 SGTC_2746 daunorubicin 9.88 µM 1.13679321999218 0.122439659614137 no 400 0.127812369169161 532 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3283 9109332 35.8195 µM 1.13624068483415 0.122549597428293 no 401 0.127927923769071 577 17027281 SGTC_2075 5212009 200 µM 1.13510377185259 0.122776026610518 no 402 0.128165920689626 591 780898 SGTC_2221 6807166 181.081 µM 1.13446359375897 0.122903654422786 no 403 0.128300068315242 601 674925 SGTC_442 cape 100 µM 1.13353374778309 0.123089196927984 no 404 0.128495088670596 634 5281787 SGTC_3176 9106582 49.47 µM 1.13286611678424 0.123222537799961 no 405 0.128635240461048 511 17018027 SGTC_1567 st069303 68.4 µM 1.1316867876166 0.123458323523505 no 406 0.128883069104825 692 5581319 SGTC_751 0833-0568 350 µM 1.131063334383 0.123583099438136 no 407 0.12901421763028 681 6954252 SGTC_2329 6138490 200 µM 1.13030200538925 0.123735589097993 no 408 0.129174494924757 593 720019 SGTC_2164 5685496 200 µM 1.12698197899816 0.12440211021297 no 409 0.129875050171527 718 759046 SGTC_1067 clotrimazole 1.36 µM 1.12650979839201 0.124497107683205 no 410 0.129974897756498 711 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_748 act1.228 77.9 µM 1.12544284770426 0.124711953013053 no 411 0.130200711422823 708 4421505 YNR035C ARC35 SGTC_1228 0124-0032 52.5 µM 1.12504122668568 0.124792892066912 no 412 0.130285782367494 683 X1228 SGTC_3075 9116269 49.47 µM 1.12416529292362 0.124969547118444 no 413 0.130471455115215 680 17015205 YNL244C SUI1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.12337368311197 0.12512934623905 no 414 0.130639410965833 702 688669 SGTC_899 1083-0020 478 µM 1.12089416229739 0.125630800520289 no 415 0.131166458036922 712 767123 SGTC_1600 coumarin 106 71.1 µM 1.12060040523165 0.125690302241422 no 416 0.131228996223127 707 100336 A hepatotoxic, DNA x-linker. SGTC_65 0798-0905 34.986 µM 1.12006237885921 0.12579933270612 no 417 0.131343590496705 778 3602145 SGTC_392 N-ethylmaleimide 8.33 µM 1.11905249156555 0.12600416336549 no 418 0.131558872985128 654 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2745 rifampicin 24.3 µM 1.11347000414704 0.127140628110916 no 419 0.132753312022691 551 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1671 st016596 74.5 µM 1.11168601388739 0.127505306276886 no 420 0.133136587670946 735 2829167 SGTC_1685 st024049 53.0905 µM 1.11024333162845 0.127800746688756 no 421 0.133447092537584 665 1941139 SGTC_449 xestospongin c 11.1929 µM 1.10871142006592 0.128114980408384 no 422 0.133777346878432 726 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_673 1082-0474 110 µM 1.10797179759201 0.128266887585941 no 423 0.133936997976434 793 3098046 SGTC_3205 9113483 49.47 µM 1.10602800098475 0.128666709890293 no 424 0.134357199942561 722 17018033 SGTC_563 tetrahydrosecaminediol 614 µM 1.1048347902864 0.128912571029911 no 425 0.134615591271197 733 334274 A psychoactive constituent of the cannabis plant. SGTC_1668 st014914 51.6 µM 1.10481372547617 0.128916914360355 no 426 0.134620155944899 694 2839556 SGTC_1710 st031758 61.5 µM 1.10389134825036 0.129107197851169 no 427 0.134820136170616 678 5394341 SGTC_2238 6671620 73.2395 µM 1.10106126806093 0.129692249377357 no 428 0.135434996330346 668 729941 SGTC_2377 9073351 62.6 µM 1.10016372520296 0.129878177853089 no 429 0.135630396266302 679 7337946 YHR072W ERG7 SGTC_164 4100-3994 89.624 µM 1.09584408920235 0.130775583247799 no 430 0.136573505163132 785 4615967 SGTC_3002 9075603 71.4286 µM 1.0949874715272 0.130954053806217 no 431 0.136761062633301 725 20105405 SGTC_621 3584-0052 32.1 µM 1.09147624237642 0.131687353237143 no 432 0.137531690089415 746 2273927 SGTC_671 0560-0003 407 µM 1.08698164413261 0.132630151656761 no 433 0.138522461005037 688 3238678 SGTC_38 0929-0051 58.268 µM 1.08684036698375 0.132659861495955 no 434 0.138553682202059 772 1379719 SGTC_2115 tiliquinol 12.7705 µM 1.08498477310841 0.133050508649951 no 435 0.138964199681914 700 71208 A bioactive hydroxyquinoline. SGTC_1081 sertraline 6 µM 1.08276860565553 0.133518101862309 no 436 0.139455571827191 745 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2143 5623677 140.463 µM 1.08197730511112 0.133685333292323 no 437 0.139631306218457 683 5375313 SGTC_19 0279-0214 38.434 µM 1.08046516417761 0.134005305683953 no 438 0.139967545672224 810 3566274 YBR002C RER2 SGTC_1383 3049-0032 20.7 µM 1.0803255270918 0.134034879721023 no 439 0.139998623083453 715 712864 SGTC_3042 9091578 49.47 µM 1.07984088005754 0.134137558943987 no 440 0.140106521744899 690 25236497 SGTC_495 decylubiquinone 155 µM 1.07872399032977 0.134374393296045 no 441 0.140355393882339 688 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2327 6189656 200 µM 1.07539389972303 0.135082236318807 no 442 0.141099205906384 722 5349088 SGTC_415 dibenzyl ketone 100 µM 1.07407765142028 0.135362721467918 no 443 0.141393940054833 753 7593 SGTC_573 3702-0553 84.7 µM 1.07314179920223 0.135562388979826 no 444 0.141603749586805 708 1222756 SGTC_416 estradiol valerate 100 µM 1.07265286315746 0.135666785495896 no 445 0.141713448429753 717 13791 A steroid. SGTC_2153 5569715 200 µM 1.07139668977311 0.135935253246914 no 446 0.14199555031427 723 2054701 SGTC_2274 7947094 46.08 µM 1.07030067745951 0.136169788528046 no 447 0.142241994791846 739 2971028 SGTC_1795 st049545 62.3 µM 1.06891309770046 0.1364671132579 no 448 0.142554414767771 725 5291882 SGTC_2910 7948405 25.97 µM 1.06808640118742 0.136644465233735 no 449 0.142740769732564 683 2971328 SGTC_2920 7982904 15.77 µM 1.06793895526216 0.13667611349965 no 450 0.142774024476333 654 6456808 SGTC_569 4130-2812 160 µM 1.0675171006844 0.136766689399074 no 451 0.142869197881868 604 743552 SGTC_926 2268-1401 59.4 µM 1.06567751219772 0.137162144838046 no 452 0.143284723287103 738 2931578 SGTC_1077 5-fluorocytosine 377 nM 1.06458486713173 0.137397399618645 no 453 0.143531915432194 713 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2162 5663267 200 µM 1.06386171980531 0.137553250158941 no 454 0.143695673285567 776 6456493 SGTC_1142 3253-1408 9.78 µM 1.06360998916806 0.137607530694403 no 455 0.143752707657309 730 256655 SGTC_3076 9116187 49.47 µM 1.06348713018579 0.137634028015851 no 456 0.143780549246295 684 27241210 SGTC_3199 9111318 49.47 µM 1.06223149092535 0.137905034721268 no 457 0.144065303520059 747 8548020 SGTC_3326 9140064 16.379 µM 1.06080999278049 0.13821227808229 no 458 0.144388129998627 725 1868434 SGTC_876 0720-0963 56.8 µM 1.06070715381174 0.138234523840236 no 459 0.144411503932072 780 765861 SGTC_335 4077-0256 27.6 µM 1.05953060871956 0.138489203585626 no 460 0.144679098488958 825 3121989 SGTC_1364 1653-0028 37.6 µM 1.05841526535515 0.138730930405888 no 461 0.14493308145934 753 5718652 SGTC_289 k017-0060 526 µM 1.05838211018727 0.138738120475159 no 462 0.144940636055749 711 5512909 SGTC_3187 9109394 49.47 µM 1.05733078547606 0.138966243637836 no 463 0.145180323945551 749 17098090 SGTC_2576 guaiol 23.12 µM 1.05693129335005 0.13905299491547 no 464 0.145271472669881 792 227829 SGTC_722 3534-0461 190 µM 1.05661204592085 0.139122347239025 no 465 0.145344340315998 734 658262 SGTC_458 nppb 133 µM 1.05658914144312 0.139127323841853 no 466 0.145349569166607 721 4549 A chloride channel blocker. SGTC_2331 7980721 200 µM 1.05589895159151 0.139277342656217 no 467 0.145507191587712 755 2981221 SGTC_2783 7738165 71.43 µM 1.05256409312234 0.140003753825746 no 468 0.146270410565936 642 17201110 SGTC_2524 avocatin b 10.57 µM 1.05220458959715 0.140082215653212 no 469 0.146352847127709 691 6710748 SGTC_1761 st044296 37 µM 1.05160922957363 0.140212218975098 no 470 0.146489435756521 731 1826700 SGTC_3291 9121177 71.43 µM 1.04163323108185 0.14240277977176 no 471 0.148790877841096 660 17015612 SGTC_2211 7117706 200 µM 1.04137112778962 0.142460643645877 no 472 0.148851668536635 729 822771 SGTC_50 0929-0078 56.389 µM 1.04054219353973 0.142643750014474 no 473 0.149044035905611 720 1377751 SGTC_2928 9011484 9.79 µM 1.03921925746555 0.142936307795723 no 474 0.149351388116035 710 2994751 SGTC_2886 9058944 51.95 µM 1.03715855412853 0.143392824717818 no 475 0.14983098503922 605 4949929 SGTC_2000 st075254 36.4 µM 1.03562291422291 0.143733661458201 no 476 0.150189048790558 735 17234175 SGTC_3086 9117350 49.47 µM 1.03531819922303 0.14380135818847 no 477 0.150260166667806 716 2679265 SGTC_1017 4239-0030 168 µM 1.03264971507824 0.144395118550565 no 478 0.150883926824133 777 1149593 SGTC_111 0083-0039 52.457 µM 1.03074818638423 0.144819231602546 no 479 0.151329460810204 653 759313 SGTC_2403 6032726 181.2 µM 1.02814616996424 0.145400937995735 no 480 0.151940537646901 736 2881040 SGTC_2396 5342950 42.78 µM 1.02535392039795 0.146026918852869 no 481 0.152598111119273 790 1886677 SGTC_3327 9140648 26.9345 µM 1.02469733074825 0.146174379043616 no 482 0.152753011459312 752 8029710 SGTC_389 tpck 16.7 µM 1.02456098532602 0.146205012717612 no 483 0.152785190667842 769 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.02053366223132 0.147111804126141 no 484 0.153737716448241 731 17037758 SGTC_1990 st072050 59.8 µM 1.01903251678182 0.147450764450114 no 485 0.15409376475842 789 17233948 SGTC_1641 st009299 47.1 µM 1.01894466028861 0.147470618741157 no 486 0.154114619833326 729 4046054 SGTC_1313 1220-0047 237 µM 1.01646429528586 0.148031884329965 no 487 0.154704170863115 831 3528706 SGTC_337 1315-0038 354 µM 1.01499524530383 0.148364979331283 no 488 0.155054046996291 787 1626437 SGTC_3305 9127027 53.8275 µM 1.01434617289197 0.148512310723785 no 489 0.155208799552287 784 41905295 SGTC_900 1112-0045 141 µM 1.01108158324382 0.149254815172896 no 490 0.155988692084141 661 56211 YIL048W NEO1 SGTC_1765 st044815 90.4 µM 1.0097024197984 0.14956923823776 no 491 0.156318941397899 763 645695 SGTC_1369 1866-0067 208 µM 1.00954031315566 0.149606224482206 no 492 0.156357789072616 853 3531355 SGTC_1051 3253-3903 78 µM 1.00825386894759 0.149899955915269 no 493 0.15666630148014 808 5509239 SGTC_975 1335-0046 28.5 µM 1.00502428962073 0.150639053524341 no 494 0.15744257701122 784 16486740 SGTC_3235 9132602 49.47 µM 1.00438492100105 0.150785661991103 no 495 0.157596557662373 821 4912240 SGTC_2184 6075246 200 µM 1.00359186733107 0.150967642688062 no 496 0.1577876880816 798 2267320 SGTC_2073 5212005 126 µM 1.00308306278617 0.151084474157098 no 497 0.157910392992806 711 691789 SGTC_2739 tacrine 100.86 µM 1.00090651535644 0.151584930964165 no 498 0.158436003176009 753 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2263 7948595 193.29 µM 0.998624704686747 0.152110773002138 no 499 0.158988263970975 743 2971371 SGTC_1926 methyl fluorone black 53.6 µM 0.9965624833023 0.15258705169911 no 500 0.159488461960608 721 72721 Reacts with homocysteine. SGTC_496 calpeptin 138 µM 0.995658348601571 0.152796177062727 no 501 0.159708087025214 708 73364 A calpain inhibitor. SGTC_969 1313-0238 134 µM 0.995222057385094 0.152897158703108 no 502 0.159814138100028 836 5212874 SGTC_2860 9025725 38.96 µM 0.994658243213579 0.15302772165649 no 503 0.159951254915392 757 40546248 SGTC_3096 9117468 49.47 µM 0.993972862280438 0.153186535434825 no 504 0.160118039746939 693 41316311 SGTC_396 dithiazanine 1.25 µM 0.993906311992936 0.153201962021795 no 505 0.160134240559195 761 10578 An antihelmenthic. SGTC_3119 9125183 49.47 µM 0.993369968420857 0.153326325898833 no 506 0.160264845629365 662 22695334 SGTC_1242 0402-0103 60.1 µM 0.99223924142315 0.153588730639397 no 507 0.16054041710645 748 432868 SGTC_2716 st080858 38.6235 µM 0.991558945910587 0.153746748164819 no 508 0.160706362178368 851 5296050 SGTC_2360 9040895 200 µM 0.987511801571559 0.154689033728734 no 509 0.161695900145743 749 4914414 SGTC_184 1494-0393 24.714 µM 0.98741079689658 0.154712599074978 no 510 0.16172064675205 796 3090647 SGTC_3118 9124250 49.47 µM 0.985112441369459 0.155249468238158 no 511 0.162284421409474 739 1504786 SGTC_1488 4013-0813 75.9 µM 0.98454884438608 0.155381305465734 no 512 0.162422863926011 782 2910057 SGTC_2651 TUB2.036 5 µM 0.983447289615625 0.155639195619565 no 513 0.162693672785309 979 15992207 YFL037W TUB2 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.980332925903355 0.156369840436499 no 514 0.163460903459725 804 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_372 0155-0182 15.9 µM 0.979236715578955 0.156627553342424 no 515 0.163731515624145 886 771486 SGTC_72 0744-0168 198.391 µM 0.979182425004154 0.156640324014819 no 516 0.163744925432567 796 677577 SGTC_2052 5265182 7.135 µM 0.9763410396939 0.157309654535165 no 517 0.164447744472093 829 1239884 SGTC_2861 9024595 19.48 µM 0.976059960958344 0.157375968856252 no 518 0.164517375661178 761 16482810 SGTC_2083 5306046 65.942 µM 0.975641565003747 0.157474714172122 no 519 0.164621059613742 808 539837 SGTC_1459 k035-0031 35.7 µM 0.975027946030318 0.157619607560276 no 520 0.164773198935941 739 3877128 YMR208W ERG12 SGTC_2447 5741742 33.78 µM 0.974246870131701 0.157804169094767 no 521 0.164966988869047 837 1776504 SGTC_860 0443-0016 25.1 µM 0.973390572484149 0.15800666791415 no 522 0.165179611317205 857 5337942 SGTC_347 4534-1311 26.2 µM 0.971673207031306 0.15841330755098 no 523 0.165606575019769 798 2862016 SGTC_1091 telmisartan 47.6 µM 0.971660484369321 0.158416322596009 no 524 0.165609740731953 861 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1053 3366-3204 134 µM 0.970000346086213 0.158810068825986 no 525 0.16602315980929 812 3632071 YPR165W RHO1 SGTC_2268 7933382 153.85 µM 0.966545868360121 0.159631445140116 no 526 0.166885553246983 944 935025 YOR257W CDC31 SGTC_784 4579-0127 173 µM 0.965830183358823 0.159801961663666 no 527 0.167064581197637 898 1948547 SGTC_1346 1488-2224 62.4 µM 0.965523317808363 0.159875110827422 no 528 0.167141381254342 857 3722427 SGTC_307 1501-1223 22.3 µM 0.965039282691102 0.15999053735092 no 529 0.1672625682695 824 2830329 SGTC_1088 bifonazole 369 nM 0.963043073105756 0.160467143650534 no 530 0.167762953975363 821 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3083 9117465 49.47 µM 0.962546752735935 0.160585786780118 no 531 0.167887515039292 833 16420915 SGTC_2269 7935389 174.42 µM 0.961852838108101 0.160751759950856 no 532 0.168061765933337 800 97605 SGTC_2298 7976326 193.81 µM 0.957416545547653 0.161815495628891 no 533 0.169178525278923 783 2235818 SGTC_839 0122-0028 230 µM 0.955523172567071 0.162270882552172 no 534 0.169656596309845 890 759448 SGTC_2884 9058502 51.95 µM 0.954204960347157 0.162588426148513 no 535 0.169989952142643 846 6471554 SGTC_2151 5563267 85.4165 µM 0.953731829172164 0.16270249704812 no 536 0.170109702149369 874 5310824 SGTC_480 am 92016 50 µM 0.951226846139671 0.163307310220343 no 537 0.170744616582125 781 2129 K+ channel blocker. SGTC_3219 9131112 49.47 µM 0.949212521846424 0.16379471492571 no 538 0.171256267098241 818 17612988 YMR079W SEC14 SGTC_530 4358-1714 28 µM 0.948025665696251 0.164082339309902 no 539 0.171558194189311 889 1564641 SGTC_3292 9120825 59.784 µM 0.947996056927352 0.164089518926637 no 540 0.171565730778626 882 24824900 SGTC_2012 4023501 200 µM 0.947220957504754 0.164277539683035 no 541 0.171763099138754 780 3477460 SGTC_2862 9027634 71.43 µM 0.946862071466239 0.164364644230852 no 542 0.17185453360939 770 5012562 SGTC_343 4130-2827 29.8 µM 0.946815477838524 0.164375955077261 no 543 0.171866406686647 857 1118244 SGTC_2811 7967822 32.47 µM 0.943766844763396 0.165117123254697 no 544 0.172644403425776 851 2232244 SGTC_1494 4358-1428 177 µM 0.941624278826648 0.165639305423441 no 545 0.173192517489076 902 1564571 SGTC_1507 4075-3230 155 µM 0.938966219886893 0.166288605120507 no 546 0.173874044079733 802 659771 SGTC_896 0964-0007 44.5 µM 0.938931069224239 0.1662972025775 no 547 0.173883068124526 892 6756758 SGTC_3024 9090631 49.47 µM 0.938346230800658 0.166440289602816 no 548 0.174033254318505 832 25236383 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.938124512561754 0.166494556133383 no 549 0.17409021299561 811 77254 SGTC_1410 3909-8106 77.9 µM 0.936647808074265 0.166856277490177 no 550 0.174469875698788 852 1039210 SGTC_3017 9080681 49.47 µM 0.935134084962972 0.167227592391457 no 551 0.174859601358434 858 16451914 SGTC_1307 1187-1599 12.2 µM 0.932114204102924 0.16796995638274 no 552 0.175638754065036 868 1538471 SGTC_1471 k673-0312 37 µM 0.93013043068642 0.168458771215173 no 553 0.176151778325775 892 24099884 SGTC_683 panaxydol 45 µM 0.929648402101067 0.168577684225309 no 554 0.176276578982748 899 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1350 1495-0454 146 µM 0.928889271976826 0.168765065584872 no 555 0.176473236629294 919 1069057 SGTC_1424 4048-1941 275 µM 0.928123857804575 0.168954133536468 no 556 0.176671662648584 971 X1424 SGTC_2847 9005661 71.43 µM 0.925017671546653 0.169722800575409 no 557 0.177478357676141 787 2991449 SGTC_331 k048-0133 24.5 µM 0.922865907338154 0.170256596138336 no 558 0.178038544627743 834 6813582 SGTC_1863 st057641 20.1 µM 0.922181866394014 0.170426513600076 no 559 0.178216860060952 955 3921635 SGTC_566 0958-0068 16.5 µM 0.9216147116729 0.170567478560526 no 560 0.178364790976858 815 6815365 SGTC_1027 k015-0025 8.67 µM 0.917291195102405 0.17164453098931 no 561 0.179495035014248 885 3598955 SGTC_2017 5132927 60.65 µM 0.915855341917034 0.172003182426679 no 562 0.179871386188118 900 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3314 9135860 59.4275 µM 0.915729059870196 0.172034748382793 no 563 0.179904509643769 930 25252478 SGTC_148 3253-0744 288.01 µM 0.915431649885781 0.172109104758993 no 564 0.179982534650848 885 6893655 SGTC_3048 9093155 49.47 µM 0.915080036617014 0.172197039119826 no 565 0.180074807204771 846 25236002 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.914696302764916 0.172293039174705 no 566 0.180175542929733 951 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.91446430051035 0.172351096559213 no 567 0.180236464054564 866 5355888 SGTC_2670 beta-carotene 100 µM 0.914184249462557 0.172421194532978 no 568 0.180310019459172 852 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3157 9099274 49.47 µM 0.912328189914901 0.172886233721183 no 569 0.180797989483433 889 17217662 SGTC_2105 5350118 200 µM 0.906644537825041 0.174315248964619 no 570 0.182297400703068 914 2133313 SGTC_3216 9129716 49.47 µM 0.90562535730714 0.174572288280479 no 571 0.182567091297943 826 8056934 SGTC_2960 9079389 5.97 µM 0.905070127942981 0.174712419437017 no 572 0.182714118187774 906 16457355 SGTC_2906 7926292 26.41 µM 0.904897658495031 0.174755962544782 no 573 0.182759803810652 909 2966319 SGTC_312 4092-0653 6.84 µM 0.903465070829942 0.175117912067414 no 574 0.183139559120961 977 1148278 SGTC_1900 st060200 72.8 µM 0.902026055587153 0.175481963916211 no 575 0.183521513423405 904 688945 SGTC_857 0438-0306 1.35 µM 0.901460932237796 0.175625063751765 no 576 0.183671648413695 914 4686136 SGTC_3195 9113082 49.47 µM 0.900319251636786 0.175914384215472 no 577 0.183975189399405 897 17018038 SGTC_692 k241-0027 77.8 µM 0.896827342578257 0.176801162919429 no 578 0.1849055276754 902 3600480 SGTC_1885 st057546 99.9 µM 0.896684142809067 0.176837589059598 no 579 0.184943742238591 954 702008 SGTC_1251 0490-5699 265 µM 0.89323488426258 0.177716419818448 no 580 0.185865700244289 1003 3883818 SGTC_806 3966-4455 5.86 µM 0.893092260530772 0.177752817905354 no 581 0.185903883641741 827 714982 SGTC_2986 9022445 71.43 µM 0.892351837769654 0.177941852018784 no 582 0.186102188682588 931 6459286 SGTC_2065 5221596 34.26 µM 0.891615055593334 0.17813008246265 no 583 0.186299648779225 882 788581 SGTC_2339 9000433 200 µM 0.891519255790317 0.178154566267467 no 584 0.186325332981334 829 2988954 SGTC_2286 7945697 125 µM 0.889521814260058 0.178665540727275 no 585 0.186861352419951 914 1245733 SGTC_604 1000-0114 314 µM 0.888002100680242 0.179054922968755 no 586 0.187269810667464 983 1572745 SGTC_1317 1273-0028 910 nM 0.887264994522244 0.179243977042963 no 587 0.187468123694531 949 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1508 1080-0625 72.9 µM 0.884229750497597 0.180023783008995 no 588 0.188286100747748 884 767111 SGTC_1662 st014054 52 µM 0.884018193216406 0.180078214978238 no 589 0.188343195925616 912 2838777 SGTC_2172 5754775 163.918 µM 0.880898668095834 0.180882042595196 no 590 0.189186334224729 844 2263357 SGTC_1796 st049173 110.4 µM 0.880462899521595 0.180994508564453 no 591 0.1893042975122 890 94134 SGTC_797 k781-0471 270 µM 0.879666590230774 0.181200138376031 no 592 0.189519976718976 962 23738129 SGTC_85 0868-0259 160.055 µM 0.879646332650649 0.181205371369851 no 593 0.189525465426325 885 83173 SGTC_2602 kawain 100 µM 0.876825925770245 0.181934870463652 no 594 0.190290597511303 992 5369129 SGTC_1893 st059353 36.1 µM 0.874219642495286 0.182610616727829 no 595 0.190999325487767 906 3112488 SGTC_175 3793-3120 23.7 µM 0.874066912036311 0.182650264600058 no 596 0.191040907716983 911 5322297 SGTC_2114 5491910 81.25 µM 0.868472341880819 0.184106283009622 no 597 0.192567903528803 946 2849228 SGTC_105 0111-0055 734.78 µM 0.868388885099153 0.184128057659193 no 598 0.192590738758704 840 5179370 SGTC_1450 4112-4260 37.6 µM 0.86790350930968 0.184254728482303 no 599 0.192723578834766 974 1633175 SGTC_941 3237-0776 460 µM 0.86759558782445 0.184335116320711 no 600 0.192807881346411 917 760008 SGTC_1482 3346-2049 8.48 µM 0.867445864588417 0.184374211854619 no 601 0.192848880599864 942 3826804 SGTC_112 phenothiazine 287.218 µM 0.864783094945517 0.185070372226568 no 602 0.193578925709438 995 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2650 prasterone 100 µM 0.863479370790093 0.18541181542678 no 603 0.193936978429359 916 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1409 3909-8004 61.9 µM 0.862243493950362 0.185735850329072 no 604 0.194276770037892 968 2119279 SGTC_1924 st058459 75.1 µM 0.861820755367863 0.185846768863543 no 605 0.194393080818601 942 688683 SGTC_1019 4262-0212 3.4 µM 0.860461362645911 0.1862037259344 no 606 0.194767386515963 1063 4677213 SGTC_3007 9078383 71.4286 µM 0.857160208994575 0.187072328786787 no 607 0.195678174956339 964 6496995 SGTC_3106 9121286 49.47 µM 0.855376839985722 0.187542611624375 no 608 0.19617128043036 927 15943471 SGTC_517 1365-0151 113 µM 0.854984620348586 0.187646139718878 no 609 0.196279831028453 928 768657 SGTC_446 go6976 132 µM 0.853806782865912 0.18795724725036 no 610 0.196606027814699 947 3501 A protein kinase C inhibitor. SGTC_2584 androsterone 48.74 µM 0.852848691018571 0.188210547104484 no 611 0.196871609109921 1099 2754130 A steroid. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.851811024700917 0.188485122299028 no 612 0.197159493192093 993 804 An inhibitor of viral and cellular DNA polymerases. SGTC_742 0kpi-0133 140 µM 0.850707311166763 0.18877744509942 no 613 0.197465980419026 996 2728852 SGTC_799 1310-0557 151 µM 0.84988436276115 0.188995587899398 no 614 0.197694690107159 960 5354492 SGTC_2262 9014885 67.46 µM 0.84900653034427 0.189228450145945 no 615 0.197938829264765 938 6457424 SGTC_955 1216-0110 33 µM 0.846850226660869 0.189801201413931 no 616 0.198539304212678 933 3619719 SGTC_2612 dictamnine 15.46 µM 0.842934220220872 0.190844082336535 no 617 0.199632616865599 931 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1636 st007707 68.9 µM 0.842729910595775 0.190898588840441 no 618 0.199689757479144 999 403051 SGTC_1587 estradiol valerate 56.1 µM 0.840556657213526 0.191478968610631 no 619 0.200298174343383 1016 13791 A steroid. SGTC_1105 epirubicin 18.1 µM 0.840437948115416 0.191510701663919 no 620 0.200331439801184 959 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2128 5255449 168.493 µM 0.838540327257358 0.192018406784684 no 621 0.200863654308279 1046 736008 SGTC_3164 9100705 49.47 µM 0.83851810559459 0.192024357026563 no 622 0.200869891708454 965 17174235 SGTC_2393 9031399 185.94 µM 0.838375985127198 0.19206241495518 no 623 0.200909786261621 1010 1526623 YDL150W RPC53 SGTC_1322 1348-1070 12 µM 0.836941555557486 0.192446794024757 no 624 0.201312710226029 989 6758089 SGTC_1557 sumaresinolic acid 42.3 µM 0.835855617674848 0.192738101576887 no 625 0.20161806657587 939 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1506 4226-2149 212 µM 0.834394042825588 0.193130600455115 no 626 0.202029486537002 1038 991114 SGTC_2519 cryptotanshinone 88.04 µM 0.832735056864852 0.193576703929871 no 627 0.202497084245997 998 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_277 nystatin 15.5 µM 0.832471285326445 0.193647690297876 no 628 0.202571489814858 1046 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2797 7859098 81.82 µM 0.832427581425857 0.193659453452783 no 629 0.202583819537145 986 972681 SGTC_1531 st059297 52.4 µM 0.831751341512582 0.193841522821155 no 630 0.202774657162866 1003 7566702 SGTC_244 nsc-207895 1.295 µM 0.831457490427409 0.193920671158913 no 631 0.202857616588406 878 42640 SGTC_1345 1488-0192 31.4 µM 0.82871355605075 0.194660695901976 no 632 0.203633256557094 1035 658348 SGTC_3131 9127911 49.47 µM 0.828479106156738 0.194724005389922 no 633 0.203699611444535 945 45595681 SGTC_1831 st055328 12 µM 0.823564736348773 0.196053934658865 no 634 0.205093459862022 1013 1103068 SGTC_3162 9099653 49.47 µM 0.822618109048279 0.196310742830767 no 635 0.205362598644709 983 25237511 SGTC_287 k060-0039 29.6 µM 0.82013711021796 0.196984773811178 no 636 0.206068974385582 1032 5861974 SGTC_1029 k015-0030 64.7 µM 0.818362393319788 0.197467782381167 no 637 0.206575144365191 987 2208316 SGTC_2335 9018011 154.17 µM 0.817583640216371 0.197679954404581 no 638 0.206797486109181 1050 6458208 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.817368357981285 0.197738632554262 no 639 0.206858976311498 1077 368090 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.814931216447588 0.198403642947585 no 640 0.207555841709243 908 88881 An O-methylated flavonoid and antioxidant. SGTC_1487 3970-0795 2.82 µM 0.814582972767495 0.198498776495442 no 641 0.20765553011395 1041 3765103 SGTC_3270 9137563 49.47 µM 0.813800858426458 0.198712535533395 no 642 0.207879521627793 970 17015724 SGTC_1977 st070720 65.3 µM 0.812121792550681 0.199171908274113 no 643 0.208360874806544 962 682188 SGTC_1492 4158-0558 28.5 µM 0.811393115224494 0.199371464727088 no 644 0.208569975805962 1014 3967268 SGTC_1203 3992-3522 103 µM 0.811133828532867 0.199442502322949 no 645 0.208644410460667 1074 5322312 SGTC_2840 9008771 71.43 µM 0.811118960422189 0.199446576248175 no 646 0.20864867919404 995 2992978 SGTC_2476 5806916 10.51 µM 0.811017028113413 0.199474507480975 no 647 0.208677946023504 983 2870194 SGTC_1720 st037298 9.481 µM 0.809006266533767 0.200025972487381 no 648 0.209255770875834 987 597396 SGTC_1766 st045414 44.774 µM 0.8068466483174 0.200619282169538 no 649 0.209877419830831 1101 253960 SGTC_2428 5615643 7.78 µM 0.804209480047044 0.201345219832008 no 650 0.210638002363139 1006 2253075 SGTC_381 3461-2219 42.7 µM 0.804163294949796 0.201357947293006 no 651 0.210651336944585 1043 2883159 SGTC_2932 9016711 44.54 µM 0.802595007107591 0.201790414460939 no 652 0.211104427568017 1066 7117328 SGTC_2489 cantharidin 73.42 µM 0.800770287080632 0.20229429415877 no 653 0.21163232168536 1044 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.800012748971172 0.202503702236144 no 654 0.211851705332976 1117 23665772 A membrane-active detergent. SGTC_1129 3453-1384 223 µM 0.799779300099886 0.202568261181003 no 655 0.211919339124138 1045 1084452 SGTC_2648 atorvastatin 78.68 µM 0.799685495556779 0.202594205753349 no 656 0.211946519325072 1037 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_579 4491-1009 110 µM 0.798780583759611 0.202844589319747 no 657 0.212208825441721 1216 1271041 SGTC_912 3474-0017 2.18 µM 0.797866669369694 0.203097651380436 no 658 0.212473933643056 1049 3360550 SGTC_3210 9128157 49.47 µM 0.797204160053917 0.203281217396533 no 659 0.212666235192615 930 17590849 SGTC_1642 st009582 77.7 µM 0.795511245382092 0.203750734466478 no 660 0.213158086085865 1038 6739311 SGTC_44 0929-0055 61.211 µM 0.795393319523606 0.203783464378183 no 661 0.213192372370483 1005 1379590 SGTC_203 k066-0004 30.888 µM 0.793573454376433 0.204288958893415 no 662 0.213721895672785 1155 6795412 SGTC_3338 9144300 39.5675 µM 0.793421087390052 0.204331314925977 no 663 0.21376626438326 1040 4901274 SGTC_2289 7946404 165.07 µM 0.792005708923705 0.204725021459523 no 664 0.214178673728153 1107 1246120 YPR165W RHO1 SGTC_603 3794-0023 45.9 µM 0.790463445083459 0.20515453617703 no 665 0.214628581222684 1055 3802260 SGTC_1359 1582-0056 520 nM 0.790020475663289 0.205278000423595 no 666 0.214757905240926 1087 3661189 SGTC_1007 4101-0031 70 µM 0.788554759962922 0.205686838618812 no 667 0.215186140577408 1072 1146276 SGTC_2908 7930301 100 µM 0.785824283668322 0.206449749216961 no 668 0.215985218940059 1064 2223178 SGTC_3030 9087619 49.47 µM 0.784413597839589 0.206844558809757 no 669 0.216398731061341 1078 25236973 SGTC_33 0986-0033 35.816 µM 0.783072716710342 0.207220246091887 no 670 0.216792205853649 1022 2848082 SGTC_73 0327-0325 16.231 µM 0.781626336592525 0.207625944107056 no 671 0.217217102215883 1119 53298 SGTC_2707 st078556 66.6 µM 0.779142087942604 0.208323850156399 no 672 0.217948009886019 1043 17250899 SGTC_1818 st052136 56.3 µM 0.778882639906846 0.208396817252788 no 673 0.218024425555198 1007 674169 SGTC_2288 7946289 167.31 µM 0.778844424410934 0.208407566242197 no 674 0.218035682534868 1106 1246052 SGTC_3224 9130643 49.47 µM 0.778223927427972 0.208582141079786 no 675 0.218218506631742 1070 17644395 SGTC_2914 7968218 45.32 µM 0.774654912244907 0.209587944876807 no 676 0.219271800075461 1005 2977111 SGTC_2486 5283202 22.39 µM 0.773201701610821 0.209998298024404 no 677 0.219701509634938 1020 1377751 SGTC_1615 st002656 86.5 µM 0.772978979834912 0.210061231210142 no 678 0.219767410428237 1080 1584458 SGTC_3257 9139206 32.98 µM 0.772804467309215 0.210110549932501 no 679 0.219819054591192 1054 4910041 SGTC_339 3091-4833 71.4 µM 0.771874126695144 0.210373586863085 no 680 0.220094491398627 1070 3240077 SGTC_2441 5730946 39.09 µM 0.771862581661487 0.210376852225861 no 681 0.220097910666469 1075 1774275 SGTC_1812 st052057 4.327 µM 0.771841426881211 0.210382835657832 no 682 0.220104176111412 1134 3645418 SGTC_1773 st048542 73.5835 µM 0.771735005468138 0.210412937475766 no 683 0.220135696662501 1025 3237138 SGTC_2839 9003951 25.97 µM 0.77140221918349 0.210507084019894 no 684 0.220234280063372 1078 2990634 SGTC_1161 k007-0610 110 µM 0.770479124184706 0.2107683605796 no 685 0.220507866837908 1145 5843850 SGTC_2236 dapsone 200 µM 0.769584703231266 0.211021702469615 no 686 0.220773140878914 1128 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2629 bisabolol 100 µM 0.767047245816356 0.211741400059019 no 687 0.22152671281249 1089 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_670 4204-0025 119 µM 0.766872879645438 0.2117909081245 no 688 0.221578549861006 1117 719039 SGTC_3111 9122088 49.47 µM 0.766073210408362 0.212018046235553 no 689 0.221816371072687 1006 16876704 SGTC_23 0213-0011 39.996 µM 0.763734313431165 0.212683203856527 no 690 0.222512794055505 1080 627608 SGTC_2011 4012611 177 µM 0.761721046900016 0.213256730224021 no 691 0.223113255516298 1126 2049887 SGTC_3248 9135562 49.47 µM 0.760819930867634 0.213513726223089 no 692 0.223382314090818 1114 17650701 SGTC_2981 9013952 38.96 µM 0.759767809129856 0.213814016931646 no 693 0.223696694004231 1058 2996344 SGTC_477 mead ethanolamide 10 µM 0.759389491475149 0.213922054331887 no 694 0.223809798914827 965 16061185 SGTC_2189 6047310 154.431 µM 0.759034425539445 0.214023480569348 no 695 0.223915981867208 1075 711535 SGTC_3093 9117344 49.47 µM 0.758615760098933 0.214143110253958 no 696 0.224041221107772 1042 24824913 SGTC_770 0389-1121 67.2 µM 0.758187952182872 0.214265392498458 no 697 0.22416923631668 1135 6753108 SGTC_712 r015-0009 80.6 µM 0.757863876378128 0.214358051565025 no 698 0.224266238867498 1041 6813872 YLR060W FRS1 SGTC_262 fenpropimorph 62.5 µM 0.757816595691045 0.214371571906528 no 699 0.224280392940967 1017 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3129 9127257 49.47 µM 0.756536205124403 0.214737899738387 no 700 0.224663886884297 1023 837894 SGTC_1309 pyrazolanthrone 13.4 µM 0.75627375785315 0.214813032456795 no 701 0.224742539226411 1124 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2495 cafestol 54.53 µM 0.753402149380862 0.215636106204548 no 702 0.225604145791909 1122 16667697 An anti-infammatory. SGTC_1329 1447-1697 50.6 µM 0.752985965270921 0.215755546353285 no 703 0.225729173897156 1066 2840515 SGTC_1637 st007924 17.4 µM 0.751889916185001 0.216070283508785 no 704 0.226058631366967 1099 683336 SGTC_1248 0469-0687 58.6 µM 0.751418547588056 0.216205721601146 no 705 0.2262004019009 1098 4017482 SGTC_35 0133-0054 64.071 µM 0.750426368928278 0.216490964353564 no 706 0.226498977263325 1081 99677 SGTC_2473 5854593 8.94 µM 0.750100608522879 0.216584665105596 no 707 0.226597056527709 1055 2872951 SGTC_1375 2910-0797 186 µM 0.749774597628357 0.216678461391757 no 708 0.226695235205386 1091 742508 SGTC_318 1488-0629 67.2 µM 0.748981264437773 0.216906808655764 no 709 0.226934248962543 1076 3662576 SGTC_3315 9136395 68.55 µM 0.747558475861494 0.217316682045786 no 710 0.227363259525708 1170 16876844 SGTC_2250 alverine citrate 130 µM 0.746487479421959 0.217625506871327 no 711 0.227686496114173 1087 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2395 5646831 180.19 µM 0.746397433175626 0.2176514834952 no 712 0.227713684684675 1095 6808628 SGTC_1441 4106-0040 13 µM 0.746211248336356 0.2177051999425 no 713 0.227769907144687 1129 2904180 SGTC_459 nigericin 15.3 µM 0.745178341087037 0.218003344338914 no 714 0.228081957247556 1183 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_504 lovastatin 124 µM 0.743717038866575 0.21842554500127 no 715 0.228523839519956 1106 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1171 0368-0077 21.4 µM 0.742337809322238 0.218824464805773 no 716 0.228941344668415 1084 3239779 SGTC_1483 3453-0561 55.9 µM 0.741184458511509 0.219158374455416 no 717 0.229290802669209 1118 4546991 SGTC_1132 3456-3614 2.5 µM 0.739947599697488 0.219516786029997 no 718 0.229665895163261 1190 3125502 SGTC_1740 st038286 13.222 µM 0.73810156401139 0.220052348006971 no 719 0.230226366713006 1122 716786 SGTC_664 1222-0054 14.9 µM 0.737468951153261 0.220236050562933 no 720 0.230418609012426 1153 6813991 SGTC_3084 9116877 49.47 µM 0.73702175239067 0.220365964310831 no 721 0.230554560656395 1053 27241325 SGTC_2888 9058547 12.99 µM 0.73600776094153 0.220660697183842 no 722 0.230862987353711 1049 16476514 SGTC_1398 3558-0053 112 µM 0.73517395695935 0.220903224770139 no 723 0.231116778796662 1059 4532369 SGTC_679 0422-0091 41.4 µM 0.734917113347634 0.220977963302465 no 724 0.231194987652027 1181 627384 YHR062C RPP1 SGTC_2608 thymoquinone 42.66 µM 0.734800014040805 0.221012042654808 no 725 0.231230649279975 1070 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2390 9097792 176.6 µM 0.734223486076828 0.221179873153642 no 726 0.231406270857049 1092 4497149 SGTC_3091 9116372 49.47 µM 0.731356724224731 0.222015485349014 no 727 0.232280645586835 1139 17169793 SGTC_1693 xanthone 101.9 µM 0.731273781832912 0.222039688439399 no 728 0.232305970706096 1152 7020 An insecticide. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.73034937538029 0.222309537746026 no 729 0.232588327225939 1110 442882 SGTC_2523 spermine 47.74 µM 0.730248607732717 0.222338964769494 no 730 0.232619117858484 1118 1103 A DNA binding polyamine. SGTC_514 4466-0038 2.65 nM 0.730108375407469 0.222379920300707 no 731 0.232661971116059 1115 5722064 SGTC_1337 1486-1011 40.3 µM 0.729332737627053 0.222606526789931 no 732 0.23289907563288 1170 X1337 SGTC_2834 9001755 58.44 µM 0.728889015697229 0.222736221562868 no 733 0.233034777212835 1039 2989575 SGTC_1377 2944-0135 198 µM 0.728393303665446 0.222881163354577 no 734 0.233186430615158 1168 1894137 SGTC_893 0958-0369 48.9 µM 0.72784811419638 0.223040633937749 no 735 0.233353283911529 1155 6819948 SGTC_2977 9011197 71.43 µM 0.727807725351112 0.223052450456928 no 736 0.23336564740884 1084 2704722 SGTC_3170 9103054 49.47 µM 0.727565190214677 0.22312341618762 no 737 0.23343989789072 1111 16432970 SGTC_3181 9108277 49.47 µM 0.726736025492939 0.223366126689713 no 738 0.233693839989827 1125 17097298 SGTC_1252 0493-0875 34.8 µM 0.726618829155592 0.223400444148456 no 739 0.233729745186897 1155 3960963 SGTC_9 0092-0002 10.449 µM 0.724918284538012 0.223898735475012 no 740 0.234251081450288 1141 759368 SGTC_430 0958-0115 16.4 µM 0.723463831548914 0.224325418013275 no 741 0.234697483604595 1074 6833180 SGTC_183 3914-0051 30.55 µM 0.722241620428853 0.224684326045695 no 742 0.235072969270139 1148 1596232 SGTC_910 3454-3003 490 µM 0.719532695434056 0.225480974363448 no 743 0.235906382277945 1133 820824 SGTC_3064 1327-0027 10 µM 0.717135967729963 0.226187141941424 no 744 0.236645102215586 1048 16000455 YPR107C YTH1 SGTC_1231 0242-0792 125 µM 0.717058551983904 0.226209972393979 no 745 0.236668984511411 1169 3707635 SGTC_782 0083-0095 30.5 µM 0.716552967566092 0.226359104838704 no 746 0.236824986887137 1185 3591729 An indicator and reagent. SGTC_18 0111-0177 500 nM 0.714644812075136 0.226922454263669 no 747 0.237414273603447 1257 721752 SGTC_2444 5485484 36.41 µM 0.714237712138632 0.227042745644712 no 748 0.23754010048477 1185 6790631 SGTC_2749 bexarotene 57.39 µM 0.713858745404585 0.227154756429637 no 749 0.237657264811998 1165 82146 An retinoic acid receptor inhibitor. SGTC_1304 1165-0502 251 µM 0.713087399408673 0.227382838520852 no 750 0.237895838106485 1164 767425 SGTC_2193 5925765 200 µM 0.712202968136834 0.227644517909335 no 751 0.2381695496195 1175 877370 SGTC_3010 9080089 71.4286 µM 0.711779462923614 0.227769881698677 no 752 0.238300675993011 1167 17027233 SGTC_104 0074-0074 590.992 µM 0.7100969221339 0.228268322228641 no 753 0.238822017419566 1044 3943124 SGTC_123 0083-0120 66.675 µM 0.709214015053637 0.228530122145032 no 754 0.239095838792946 1132 16001701 SGTC_889 0919-1524 82.7 µM 0.708394853661483 0.228773170931378 no 755 0.239350043713162 1156 3905452 SGTC_913 3487-1245 167 µM 0.706757234370762 0.229259494528858 no 756 0.23985867750726 1146 4016153 SGTC_3252 9135871 49.47 µM 0.706718240313528 0.229271081650447 no 757 0.239870795987838 1218 17682838 SGTC_2658 polymyxin b sulfate 77.05 µM 0.705709629873119 0.229570905273991 no 758 0.240184365556626 1164 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_891 0929-0073 133 µM 0.703999010762615 0.230079912693481 no 759 0.240716694831657 1193 5603632 SGTC_2827 7993847 71.43 µM 0.702972050155955 0.230385795540413 no 760 0.241036583924332 1127 2985692 SGTC_1950 st077106 7.18 µM 0.701015142490034 0.230969294417332 no 761 0.241646782639121 1154 13831864 SGTC_3231 9132313 49.47 µM 0.69840117773053 0.231749996027361 no 762 0.24246317002464 1178 4905967 SGTC_41 0478-0632 82.643 µM 0.698082888084208 0.231845158535511 no 763 0.242562679443549 1203 3750424 SGTC_2040 5100729 123 µM 0.696109462537926 0.232435660552647 no 764 0.243180140507521 1189 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1140 3229-1848 2.98 µM 0.695528532742581 0.232609649605605 no 765 0.243362068204023 1201 2849525 SGTC_3153 9100258 49.47 µM 0.694962932974254 0.232779116839208 no 766 0.243539265689961 1155 25236848 SGTC_2921 7974240 10.71 µM 0.693687881419074 0.233161404359253 no 767 0.243938983745883 1193 2979074 YDR527W RBA50 SGTC_565 1418-0001 44.5 µM 0.692191326111992 0.233610547662252 no 768 0.244408592568233 1228 2862145 SGTC_1631 benzylvanillin 81.9 µM 0.691612022383586 0.233784535892315 no 769 0.244590504815009 1200 75506 SGTC_3159 9100096 49.47 µM 0.691601006690359 0.233787845044118 no 770 0.244593964655871 1176 25236875 SGTC_537 1334-0398 209 µM 0.690997650665117 0.233969134897721 no 771 0.244783508719595 1199 5846986 SGTC_1078 idebenone 36.1 µM 0.690474332558179 0.234126438874709 no 772 0.24494797291181 1220 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2412 st077135 33.4 µM 0.689870662218304 0.234307968616749 no 773 0.245137763381929 1257 13258915 SGTC_2226 7298446 200 µM 0.688090806317403 0.234843642363781 no 774 0.245697799824045 1204 3283010 SGTC_968 1309-0633 340 µM 0.687666986286251 0.234971296928739 no 775 0.245831257138548 1192 3761976 SGTC_3039 9090270 49.47 µM 0.687537187482625 0.235010399987394 no 776 0.245872137457117 1202 17173750 SGTC_2182 6325192 200 µM 0.686245380547291 0.235399764340397 no 777 0.246279192678114 1155 736248 SGTC_1047 2043-3044 82 µM 0.684277725323629 0.235993520131771 no 778 0.246899904894156 1212 669592 SGTC_2870 9038528 12.99 µM 0.683650905597214 0.236182841213032 no 779 0.247097815777901 1207 6463316 SGTC_718 1130-0073 349 µM 0.68336936689754 0.236267902785112 no 780 0.247186735887942 1270 6740020 SGTC_1739 st037196 92.5 µM 0.6824375357799 0.236549558145838 no 781 0.247481163884572 1228 612214 SGTC_380 3970-0968 6 µM 0.682081967508287 0.236657080925773 no 782 0.247593561143944 1186 2891601 SGTC_202 3594-0513 34.79 µM 0.68196037905725 0.236693855076993 no 783 0.247632002236884 1194 708429 SGTC_1610 st001799 48.1 µM 0.681574954244601 0.23681044670861 no 784 0.247753878223341 1151 621897 SGTC_1226 3909-7979 35.4 µM 0.681000242229993 0.236984356664738 no 785 0.247935668579669 1228 6615510 SGTC_3081 9117243 49.47 µM 0.679406235635306 0.237467076038892 no 786 0.248440249984044 1236 45595589 SGTC_2030 5175110 200 µM 0.679338973965344 0.23748745702028 no 787 0.248461553634332 1251 2831986 SGTC_1149 3909-7961 23.3 µM 0.679226862167261 0.237521430188076 no 788 0.248497064736891 1190 735261 SGTC_1044 1222-0021 1.78 µM 0.679105335332644 0.237558259401156 no 789 0.248535561080711 1188 4306703 SGTC_1354 1498-1681 81 µM 0.679095608046091 0.237561207431296 no 790 0.248538642553696 1267 5754243 SGTC_1677 st019204 53.9 µM 0.677171909783641 0.238144613421485 no 791 0.249148444042917 1185 3945625 SGTC_3144 9087057 49.47 µM 0.675344738353526 0.238699471613765 no 792 0.24972838315237 1169 17249618 SGTC_501 nsc-95397 161 µM 0.675229449373286 0.238734505192692 no 793 0.249764999580106 1242 262093 SGTC_2223 6903751 107.57 µM 0.674031063318297 0.239098832757956 no 794 0.250145782488747 1200 5598863 SGTC_1120 ficusin 1.78878 µM 0.673816572428255 0.239164073295771 no 795 0.250213968680433 1270 6199 A DNA cross-linker. SGTC_661 1304-0007 33.6 µM 0.670650829604531 0.240128110714424 no 796 0.251221496766082 1240 3117130 SGTC_954 1189-0853 2.85 µM 0.669555428437911 0.24046217675104 no 797 0.251570617664093 1221 2828194 SGTC_2607 solasodine 47.35 µM 0.669337384358757 0.240528704153514 no 798 0.251640142181617 1254 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_605 1315-0399 119 µM 0.669252373635277 0.240554644480184 no 799 0.251667251053667 1281 24020461 SGTC_1590 st077108 57.8 µM 0.668917979270105 0.24065669696302 no 800 0.251773900260528 1217 5489485 SGTC_485 niflumic acid 177 µM 0.668486954530294 0.240788274442359 no 801 0.251911403222337 1250 4488 A COX2 inhibitor. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.66786895904185 0.240976996133951 no 802 0.252108621618412 1259 676296 Flavone; oxidizing agent. SGTC_3345 9148410 3.559 µM 0.666717802063503 0.241328747534347 no 803 0.25247620272483 1203 4903596 SGTC_310 1273-0058 1.06 µM 0.666576677967785 0.241371889076806 no 804 0.252521285119572 1258 2734232 SGTC_2831 7999036 19.48 µM 0.665983784508752 0.241553181983923 no 805 0.252710732536706 1248 2988270 SGTC_816 0325-0417 81.3 µM 0.665095669826129 0.241824884892878 no 806 0.252994652042027 1230 68101 SGTC_60 0986-0278 202 µM 0.663798870158156 0.242221915393625 no 807 0.253409524463465 1083 3110598 SGTC_3351 9150312 21.596 µM 0.663621190683945 0.24227634156761 no 808 0.253466395556682 1239 4904905 SGTC_232 clozapine 119 µM 0.663519092417837 0.242307618960493 no 809 0.253499077885963 1220 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1568 digitonin 820 nM 0.66316511740225 0.242416074724301 no 810 0.25361240477014 1264 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_768 0384-0033 77.3 µM 0.661696405428219 0.242866359837963 no 811 0.25408290443516 1239 3965305 YMR134W ERG29 SGTC_1835 st008666 49.2 µM 0.661219975692297 0.243012523224174 no 812 0.254235626277987 1200 690455 SGTC_1828 st055811 49 µM 0.660666322656605 0.243182437622288 no 813 0.254413162869594 1218 5877589 SGTC_1259 0671-0132 43 µM 0.660392483334144 0.243266501795486 no 814 0.25450099728852 1209 X1259 SGTC_2488 5268135 45.7 µM 0.659955705781878 0.243400617829242 no 815 0.254641127290389 1258 1270356 YLR208W SEC13 SGTC_196 k015-0023 18.111 µM 0.659217649481387 0.243627334671149 no 816 0.254878007429472 1246 5211998 SGTC_1749 st037932 54.2 µM 0.658591775317612 0.24381968061404 no 817 0.255078972895423 1245 594497 SGTC_934 2950-0684 338 µM 0.658220427286092 0.243933843382541 no 818 0.255198250296244 1268 1121253 SGTC_2776 terbinafine 19.92 µM 0.657816741879718 0.244057980274819 no 819 0.255327947575208 1257 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_575 k072-0246 11.9 µM 0.657176142520793 0.24425504025418 no 820 0.255533831987878 1269 6796779 SGTC_2149 5554786 194.827 µM 0.654276914516219 0.245147966924883 no 821 0.256466708095033 1283 745063 YPR165W RHO1 SGTC_2198 6589944 200 µM 0.653331903783253 0.245439397536691 no 822 0.256771164414808 1230 5290268 SGTC_778 3456-2434 196 µM 0.652586374881184 0.245669441510827 no 823 0.257011485897172 1306 5539063 SGTC_558 k064-0027 21.3 µM 0.652405043323288 0.245725411547105 no 824 0.257069955868273 1284 5088526 SGTC_1360 1598-0022 39.8 µM 0.651949704793422 0.24586598711121 no 825 0.257216809290587 1299 761525 SGTC_882 0843-0131 351 µM 0.649208968255025 0.246713039126715 no 826 0.25810165786023 1282 5425421 SGTC_1114 scopoletin 1.73284 µM 0.648994856845009 0.246779278141902 no 827 0.258170850279351 1286 5280460 A coumarin with genotoxic properties. SGTC_3334 9142812 21.919 µM 0.648132928998134 0.247046026502707 no 828 0.258449488837126 1304 45283678 SGTC_346 4513-0042 7.16 µM 0.647357579978871 0.247286112283551 no 829 0.258700271773665 1278 2827372 SGTC_1830 st055982 50.3 µM 0.647300916677009 0.247303662888693 no 830 0.258718604185954 1237 455313 An antimicrobial agent. SGTC_409 arachidonic acid 100 µM 0.644945466585267 0.248033816942212 no 831 0.259481263064969 1295 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2469 5655019 90.81 µM 0.643758985811717 0.248402043241477 no 832 0.259865866747547 1348 2788239 SGTC_1530 rhein 70.4 µM 0.643703423105705 0.24841929435949 no 833 0.259883884882641 1308 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3329 9141233 27.5565 µM 0.643390925239695 0.24851633064123 no 834 0.259985235161273 1278 4909101 YNL103W MET4 SGTC_1520 flindersine 88 µM 0.642720667101278 0.248724526100961 no 835 0.260202684086569 1394 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2148 5546263 113.568 µM 0.642057597005759 0.248930580167447 no 836 0.260417893219554 1267 792097 SGTC_2252 omeprazole 400 µM 0.641518957937645 0.249098033200758 no 837 0.260592783896806 1236 4594 A proton pump inhibitor. SGTC_1280 0880-0253 10.1 µM 0.640358827979651 0.249458899805755 no 838 0.260969671652204 1269 6836607 SGTC_1451 4152-0210 104 µM 0.638768573741644 0.249954010671298 no 839 0.261486747577594 1305 659563 SGTC_2619 obliquin 87.91 µM 0.638475374913355 0.250045352304744 no 840 0.261582139454333 1271 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3166 9102297 49.47 µM 0.638400660412913 0.250068631301599 no 841 0.261606450580304 1241 25237072 SGTC_2183 6420625 130.508 µM 0.63734183631004 0.250398655529656 no 842 0.261951102785878 1280 2897619 SGTC_3034 9090421 49.47 µM 0.633295091664772 0.251662107082293 no 843 0.263270478988514 1243 17173761 SGTC_3071 9117417 49.47 µM 0.633140088413604 0.251710568180874 no 844 0.263321082719072 1240 45595590 YGL055W OLE1 SGTC_3284 9108171 64.8615 µM 0.631979622047554 0.25207353949433 no 845 0.263700096547454 1271 8687505 SGTC_1509 1326-1131 80 µM 0.630477892064011 0.252543660988112 no 846 0.264190981399606 1263 768313 SGTC_600 1495-0418 41.6 µM 0.629528505065555 0.25284110785697 no 847 0.264501556561876 1299 5377768 SGTC_1296 1068-0102 11.9 µM 0.628573148153958 0.253140611185002 no 848 0.264814272106018 1273 767053 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.627185066645396 0.253576105491345 no 849 0.265268965437286 1266 688662 SGTC_269 exalamide 29 µM 0.627090779562074 0.253605701227266 no 850 0.265299865390976 1337 3316 A derivative of salicylamide. SGTC_730 1436-0052 41.2 µM 0.627047736247399 0.253619212679769 no 851 0.265313972240572 1305 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1872 amphotericin b 148 nM 0.626639293858939 0.253747443040709 no 852 0.265447852516697 1292 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3031 9088762 49.47 µM 0.625400557184354 0.254136552118485 no 853 0.265854098271056 1258 205253 SGTC_304 1310-0298 97 µM 0.625310571029646 0.254164830547352 no 854 0.265883621651231 1247 1550234 SGTC_1291 0993-0025 5.79 µM 0.625276853115092 0.254175426931824 no 855 0.265894684523252 1336 4353356 SGTC_1838 st055369 84.5 µM 0.624165293760099 0.254524881595389 no 856 0.266259518487782 1268 676036 SGTC_1686 st019653 115.5 µM 0.62234465664676 0.255097801121106 no 857 0.266857631536858 1329 97252 SGTC_3230 9131665 49.47 µM 0.621482271808448 0.255369412297722 no 858 0.267141177684583 1253 15943720 SGTC_1289 0976-0073 69.1 µM 0.620694016131605 0.25561780838194 no 859 0.267400483653035 1343 3391136 SGTC_221 trifluoperazine 10.304 µM 0.620629617098364 0.255638107457683 no 860 0.267421674080448 1300 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_379 3970-0972 5.9 µM 0.62039177332968 0.255713084957426 no 861 0.26749994363745 1321 2898042 YBL034C STU1 SGTC_903 1134-0042 114 µM 0.620355468554256 0.255724530628354 no 862 0.267511891818328 1297 701009 SGTC_2967 9089538 49.85 µM 0.620155372663095 0.255787618911963 no 863 0.26757774974396 1353 728216 SGTC_1790 st045711 43.5 µM 0.619505853415989 0.255992461975302 no 864 0.267791583512562 1349 585119 SGTC_731 3966-0296 387 µM 0.619422252959822 0.256018833804332 no 865 0.267819112583922 1334 660956 SGTC_875 0709-0210 25.7 µM 0.617397369412546 0.256658017522989 no 866 0.268486328352265 1340 6251364 SGTC_417 st075190 100 µM 0.616445676356316 0.256958719971392 no 867 0.268800207465975 1361 222757 SGTC_2693 st077581 40.7 µM 0.614381025048031 0.257611708750262 no 868 0.269481785803699 1327 25238761 SGTC_1136 pergolide 1.05886 µM 0.614357902166588 0.257619026717067 no 869 0.269489423982621 1330 47811 A dopamine receptor agonist. SGTC_367 0335-0881 7.1 µM 0.612210074862716 0.258299244969751 no 870 0.270199388345337 1322 23828853 SGTC_166 k072-0058 166.424 µM 0.611063123435872 0.258662866072664 no 871 0.27057889591233 1308 5846229 SGTC_2354 9060492 162 µM 0.610715334048474 0.258773179018444 no 872 0.270694026350054 1343 6471895 SGTC_610 4215-0184 155 µM 0.610590107187718 0.258812904833897 no 873 0.270735486804674 1362 5605015 SGTC_1462 k081-0014 26.5 µM 0.609810891873228 0.25906016681507 no 874 0.270993542783184 1139 3270634 SGTC_2212 7123476 200 µM 0.609790591176901 0.259066610300198 no 875 0.271000267489015 1296 1085715 SGTC_2781 5567276 71.43 µM 0.60915798975858 0.259267440884509 no 876 0.271209861536756 1351 2853274 SGTC_1340 1486-1359 257 µM 0.608758249770929 0.259394386931868 no 877 0.271342345389467 1328 4309068 SGTC_919 tnp00227 403.569 nM 0.608555699527515 0.25945872338172 no 878 0.27140948792668 1346 1269246 A methoxyflavone. YNL221C POP1 SGTC_354 2783-3500 4.88 µM 0.607422904978966 0.259818687121373 no 879 0.271785145811284 1284 6740761 SGTC_844 0330-0132 15.3 µM 0.603879135614277 0.260946438571409 no 880 0.272962000673702 1333 2828079 SGTC_2819 7996655 46.38 µM 0.602773047431154 0.261298949307462 no 881 0.273329839606043 1271 6456960 SGTC_1519 esterone 74 µM 0.602741927047584 0.261308870922985 no 882 0.27334019250111 1282 698 A steroid. SGTC_95 0471-0001 561.058 µM 0.601772438607141 0.261618054352814 no 883 0.273662811848145 1246 4015405 SGTC_2295 7971645 200 µM 0.601023100898396 0.26185715721207 no 884 0.273912300036929 1387 2978226 YKL099C UTP11 SGTC_780 0109-0199 192 µM 0.599242843720093 0.262425660697465 no 885 0.2745054781452 1423 610414 SGTC_1616 st002734 56.1 µM 0.599091759037935 0.262473936828901 no 886 0.2745558484206 1337 4026101 SGTC_3136 9095672 49.47 µM 0.598508819163509 0.262660246375839 no 887 0.274750238063683 1214 17217380 SGTC_656 4090-1979 187 µM 0.596936443286002 0.263163120185544 no 888 0.275274907427444 1362 22330961 SGTC_1467 k284-1082 293 µM 0.596399393600197 0.263334990860776 no 889 0.275454222738704 1387 3334705 SGTC_1851 st056236 18.9 µM 0.596396348350555 0.263335965587844 no 890 0.275455239679742 1368 5393171 SGTC_2829 7992743 58.44 µM 0.596252319803155 0.263382068517818 no 891 0.275503339172731 1351 16462845 SGTC_2919 7978188 46.38 µM 0.593889566474094 0.264138963727656 no 892 0.276292988917206 1342 2980291 SGTC_2088 5278280 127.392 µM 0.590169544468549 0.265332894057409 no 893 0.27753849405245 1358 791502 SGTC_2549 cedrol 20.94 µM 0.590004943942521 0.26538578533536 no 894 0.277593667481091 1387 6708665 A sedative which affects the nervous system. SGTC_1040 k898-0338 155 µM 0.588421610871657 0.265894832724561 no 895 0.278124667840481 1424 20969351 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.588349235209816 0.26591811358505 no 896 0.278148952208309 1410 688801 SGTC_636 0kpi-0074 126 µM 0.586705365157123 0.26644717028476 no 897 0.278700801925615 1338 616434 SGTC_2200 6600604 21.907 µM 0.586431366539487 0.26653540467166 no 898 0.278792835486439 1316 2904777 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.586339059123779 0.266565133288531 no 899 0.278823844010595 1367 165521 SGTC_3332 9141069 11.198 µM 0.585603275620557 0.266802160382552 no 900 0.279071073316441 1325 17332883 SGTC_1809 st050081 57.6 µM 0.585279810374183 0.266906395959133 no 901 0.279179794020085 1412 5036894 SGTC_1400 3771-8998 51.5 µM 0.583109508265123 0.267606300096031 no 902 0.279909791655615 1343 670767 SGTC_2237 6667747 47.222 µM 0.581338783697756 0.2681780284111 no 903 0.280506073235074 1377 729940 YDL015C TSC13 SGTC_1117 retinoic acid 1.10837 µM 0.580749278603571 0.268368503027682 no 904 0.280704722093505 1438 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_886 0866-0150 153 µM 0.580742896191026 0.268370565617192 no 905 0.280706873183366 1423 271463 SGTC_835 0312-0010 67.2 µM 0.579680618414664 0.26871397052199 no 906 0.281065007936583 1342 1626196 SGTC_1397 3532-0190 20.1 µM 0.577607077645625 0.269384924088651 no 907 0.281764713720245 1360 5322280 SGTC_2787 5284540 71.43 µM 0.572623199681158 0.271001028729012 no 908 0.283449924012465 1408 736958 SGTC_991 3996-0057 64.7 µM 0.572421681643022 0.271066475873049 no 909 0.283518165274003 1386 715343 SGTC_2742 clothiapine 36.27 µM 0.571823267081823 0.271260869809334 no 910 0.283720856375746 1387 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_729 4092-0585 94.1 µM 0.571702257694698 0.271300187944813 no 911 0.283761852324884 1341 2169061 SGTC_382 3229-0966 23.2 µM 0.571472406394425 0.271374878604418 no 912 0.283839729897014 1449 5722370 SGTC_2858 9025781 8.96 µM 0.570568317043427 0.271668763701401 no 913 0.284146150142859 1390 4894980 YPL153C RAD53 SGTC_2130 NSC 7 2.4545 µM 0.57012185731667 0.271813949212378 no 914 0.284297525702751 1411 21448 SGTC_2361 9034121 116 µM 0.569247514373051 0.272098391085506 no 915 0.284594089928313 1385 6496917 SGTC_1932 st074806 40.9 µM 0.568265963824866 0.2724178860293 no 916 0.284927193290524 1474 17251235 SGTC_1158 4092-0494 91.8 µM 0.564780367498142 0.273553951952864 no 917 0.286111581090271 1480 1148199 SGTC_623 k072-0108 16.9 µM 0.562299159892024 0.274364081979146 no 918 0.286956105312108 1401 5382803 SGTC_473 2-arachidonoylglycerol 10 µM 0.56194223049955 0.274480719057255 no 919 0.287077689825836 1347 5282280 An endocannabinoid. SGTC_3271 9137798 49.47 µM 0.558943831444523 0.275461498322018 no 920 0.288100027162443 1388 6498326 SGTC_1946 st076057 65.1 µM 0.55750223653603 0.275933658346067 no 921 0.288592165713334 1312 953009 SGTC_1553 gossypol 38.6 µM 0.555383136350213 0.276628439930922 no 922 0.28931631237475 1340 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3058 9093861 49.47 µM 0.554090851880181 0.277052556931699 no 923 0.289758335274646 1426 17217477 SGTC_39 0986-0283 58.349 µM 0.552052784578336 0.277722079717891 no 924 0.290456094689382 1496 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2774 tamoxifen 10.92 µM 0.552005078883931 0.277737760912062 no 925 0.290472436783927 1430 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1877 wortmannin 25 µM 0.55151846720076 0.277897738258829 no 926 0.290639155385841 1397 312145 A covalent inhibitor of PI 3-kinase. SGTC_1474 0330-0125 5.35 µM 0.550614695367501 0.278194979515696 no 927 0.290948916433514 1412 X1474 SGTC_2692 st077426 47.7 µM 0.550000352553191 0.278397119019758 no 928 0.291159565882408 1422 25238571 SGTC_958 1222-0007 33 µM 0.549143969922794 0.278679017163364 no 929 0.291453326126882 1497 7312461 SGTC_1163 k060-0048 49.9 µM 0.548479985774407 0.278897678505364 no 930 0.291681184083319 1399 6809982 SGTC_2682 pyrogallin 40.03 µM 0.546648126708803 0.279501373517581 no 931 0.292310249205406 1433 822798 An ATP competetive kinase inhibitor. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.542217455630261 0.280964133303665 no 932 0.293834355827502 1446 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1001 4048-4355 44.4 µM 0.541503337181298 0.281200241022877 no 933 0.294080349041623 1395 21824233 SGTC_1694 st024011 44.9 µM 0.540296574525197 0.28159944845188 no 934 0.294496260170525 1461 2787533 SGTC_939 1165-0479 45.3 µM 0.540025758758815 0.281689074165254 no 935 0.294589634193738 1373 1377347 SGTC_1667 st014849 34.6 µM 0.539390647881469 0.281899316247252 no 936 0.294808666355449 1446 5348460 SGTC_1294 1000-1494 117 µM 0.539253532640197 0.281944715713155 no 937 0.294855963458963 1379 712797 YDL207W GLE1 SGTC_411 enrofloxacin 100 µM 0.53875840787639 0.282108683039531 no 938 0.295026782972118 1568 71188 A bacterial gyrase inhibitor. SGTC_1003 4049-0218 100 µM 0.537042665937071 0.282677229337221 no 939 0.295619071426094 1496 295161 SGTC_535 2293-4129 48.2 µM 0.536537537792892 0.282844718770576 no 940 0.295793549974171 1513 396118 YIL048W NEO1 SGTC_1009 4106-0057 9.87 µM 0.536476034113389 0.282865115298767 no 941 0.295814797462739 1426 2928005 SGTC_2704 st078022 71.1 µM 0.535611068392917 0.283152039564388 no 942 0.296113688767118 1531 54697681 SGTC_1758 st042942 75.2445 µM 0.535293122710171 0.283257542799296 no 943 0.296223590601176 1400 669317 SGTC_161 4065-0411 162.148 µM 0.53497275640329 0.283363868331874 no 944 0.296334348074111 1488 1906281 YLR208W SEC13 SGTC_2820 7989630 71.43 µM 0.534935769185092 0.283376145154717 no 945 0.296347136567772 1371 2984098 SGTC_2857 9024691 58.44 µM 0.534717453839941 0.283448613728297 no 946 0.296422625214323 1453 16478292 SGTC_2491 paeonol 100 µM 0.534671370161988 0.283463912086197 no 947 0.296438561063548 1401 11092 Increases levels of cortical cytochrome oxidase. SGTC_1588 farnesol 29.9 µM 0.534574111640439 0.283496200210701 no 948 0.296472194588394 1426 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1901 st060216 58.6 µM 0.533869329748794 0.283730228095844 no 949 0.296715971475524 1420 688792 SGTC_2518 prenyletin 46.28 µM 0.532636691307453 0.284139756798856 no 950 0.297142549060021 1385 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2027 5150920 200 µM 0.532625059254293 0.284143622749032 no 951 0.297146575884654 1461 786715 SGTC_1961 st076550 68.7 µM 0.530582685729022 0.28482280178224 no 952 0.297853998260068 1429 1579337 SGTC_1958 st076513 41.9 µM 0.530524024283735 0.284842320731315 no 953 0.297874328323283 1375 732122 YGL099W LSG1 SGTC_2415 st077333 57.7 µM 0.526868152962594 0.286060029060964 no 954 0.299142575466409 1657 2766255 SGTC_2996 9066192 71.4286 µM 0.52414501320745 0.286968664876641 no 955 0.300088841239843 1388 6472854 SGTC_373 0844-0104 25.9 µM 0.523985812466729 0.287021827999235 no 956 0.300144203886249 1490 5375804 SGTC_1116 jasmonic acid  1.58368 µM 0.523646816267805 0.28713504713514 no 957 0.300262106454714 1497 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1054 3429-0080 167 µM 0.522287862294667 0.287589127481209 no 958 0.300734959444955 1502 1162877 SGTC_2103 5378138 10 µM 0.522126480970555 0.287643073914518 no 959 0.300791134979754 1490 244142 SGTC_186 3455-3465 67.277 µM 0.52052425514078 0.288178924094453 no 960 0.301349113464764 1421 755278 SGTC_2241 6772625 37.8075 µM 0.520435666704112 0.288208565443073 no 961 0.301379978163933 1395 2285411 SGTC_2382 9035899 200 µM 0.519873777961392 0.288396604727025 no 962 0.301575776425849 1457 6462679 SGTC_3032 9089427 49.47 µM 0.51717309666858 0.289301209245863 no 963 0.302517665317225 1431 17173707 SGTC_808 0711-0032 135 µM 0.516884652606824 0.289397903555678 no 964 0.302618340891342 1527 4252555 SGTC_1621 st003705 32.4 µM 0.516844138609542 0.289411486167576 no 965 0.302632482686259 1549 24207032 SGTC_758 0868-0029 16 µM 0.515491554789468 0.289865121520245 no 966 0.303104784761534 1514 762687 SGTC_3246 9135460 32.98 µM 0.51360258938594 0.290499208363064 no 967 0.303764934420562 1483 41446951 SGTC_1314 1222-0010 41.1 µM 0.512375525514837 0.290911455984601 no 968 0.304194108249313 1466 3526027 SGTC_1148 3909-7663 27.7 µM 0.511021333459317 0.29136673103868 no 969 0.304668059303668 1520 4084526 SGTC_2714 st079313 56.9 µM 0.509901130948778 0.29174359062654 no 970 0.305060364796319 1464 2939799 SGTC_2583 asiatic acid 100 µM 0.509287540869763 0.291950111420491 no 971 0.305275344869944 1473 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3190 9110366 49.47 µM 0.50914204712826 0.291999091365975 no 972 0.305326330543617 1521 17123768 SGTC_1510 1123-0200 71.5 µM 0.50897390381353 0.292055700974072 no 973 0.305385258058915 1577 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1211 1056-0033 32.3 µM 0.508762631283268 0.292126838341492 no 974 0.305459307790894 1479 6741922 SGTC_247 mechlorethamine 29.705 µM 0.508695031197822 0.292149601603 no 975 0.305483002889143 1450 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_75 0159-0059 199.013 µM 0.508483657708636 0.292220783613297 no 976 0.305557098519751 1566 5377270 SGTC_1715 st032160 10.2275 µM 0.50760909697522 0.292515385885797 no 977 0.30586375483425 1501 5289825 SGTC_2215 7188065 200 µM 0.506929203885774 0.292744508239263 no 978 0.306102246894975 1510 940217 SGTC_1033 k072-0102 21.3 µM 0.505812614202802 0.293120977023283 no 979 0.306494101189305 1574 5965931 SGTC_133 0724-0033 378.92 µM 0.504884644806044 0.293434021425043 no 980 0.306819929821818 1379 280309 SGTC_3237 9133362 49.47 µM 0.504589840418577 0.29353350416216 no 981 0.306923473513462 1516 43845137 SGTC_152 4469-0003 551.229 µM 0.502155310094479 0.294355641070458 no 982 0.307779138081166 1492 697280 SGTC_2533 agelasine 13.65 µM 0.501812135169026 0.294471616131834 no 983 0.307899838058238 1623 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_846 0335-0850 148 µM 0.500974739384003 0.29475470031368 no 984 0.308194450452788 1469 6819598 SGTC_1216 1165-0504 9.65 µM 0.500905299600413 0.29477818027595 no 985 0.3082188862943 1529 6304004 SGTC_1562 morin hydrate 59.1 µM 0.499544875066041 0.295238360112921 no 986 0.308697790662019 1503 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_361 000s-0510 1.45 µM 0.498637449926563 0.295545491224698 no 987 0.309017408657509 1482 660 SGTC_492 tmb-8 126 µM 0.498411637744786 0.295621943432666 no 988 0.309096967881841 1427 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2375 9072683 200 µM 0.498373588236025 0.295634826577493 no 989 0.309110374547791 1610 16798029 SGTC_2063 5246145 200 µM 0.498311072189423 0.295655994383038 no 990 0.309132402499895 1518 711240 SGTC_233 rapamycin 362 pM 0.498030521879745 0.295750996720845 no 991 0.309231264749081 1504 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2084 5306078 60.6385 µM 0.497723176982583 0.295855088566807 no 992 0.309339584915525 1508 679340 SGTC_2363 9053361 176 µM 0.497001603530478 0.296099537814822 no 993 0.309593960271243 1595 6469797 YMR079W SEC14 SGTC_503 tyrphostin 8 294 µM 0.49651181537446 0.29626551736707 no 994 0.309766676647932 1539 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_119 0121-0043 24.815 µM 0.496455683064435 0.296284542225609 no 995 0.309786473540672 1501 1092378 SGTC_2953 9074162 66.49 µM 0.495580271270786 0.296581316999964 no 996 0.310095287469316 1611 16451992 SGTC_2775 cyproheptadine 69.59 µM 0.494303969826062 0.297014241853396 no 997 0.310545760964976 1492 2913 A selective serotonin reuptake inhibitor. SGTC_1997 st073024 93.8 µM 0.493979719153712 0.297124274574344 no 998 0.310660251285098 1486 686268 SGTC_2708 st078559 56 µM 0.490454274497397 0.298321816225991 no 999 0.311906239373388 1449 17250902 SGTC_1101 ebselen 5.29 µM 0.490242703609102 0.298393753580857 no 1000 0.311981082984893 1599 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2557 derrustone 83.84 µM 0.490159004830256 0.29842221463181 no 1001 0.312010693733249 1449 629853 An antioxidant. SGTC_497 capsazepine 133 µM 0.489335825726806 0.298702195413564 no 1002 0.312301980716987 1422 2733484 A calcium channel blocker. SGTC_1031 k035-0009 16 µM 0.487123785801222 0.299455148339827 no 1003 0.313085305616565 1623 5180959 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.486970199893562 0.299507459147475 no 1004 0.313139724659629 1590 16725076 SGTC_2882 9058044 58.44 µM 0.48566943543108 0.299950660837506 no 1005 0.313600778740925 1417 18076804 SGTC_263 alizarin 107.927 µM 0.485303697765964 0.300075329880195 no 1006 0.313730466430705 1535 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1908 st060353 56.5 µM 0.484262972135681 0.300430210327349 no 1007 0.314099625436639 1672 4227716 SGTC_557 1315-0110 16.2 µM 0.48207842782528 0.301175741223109 no 1008 0.314875116829633 1446 6833801 SGTC_350 k064-0020 19.8 µM 0.481350394236587 0.301424386109193 no 1009 0.315133743151809 1592 2790705 SGTC_584 0986-0246 15.4 µM 0.481070544193172 0.301519987709134 no 1010 0.315233181079474 1573 53315 YDR232W HEM1 SGTC_253 dyclonine 31.25 µM 0.48065267827855 0.30166276329931 no 1011 0.315381684518926 1564 3180 An oral anasthetic. SGTC_2983 9022671 12.99 µM 0.479326096072271 0.302116228589645 no 1012 0.315853330020983 1642 6405161 SGTC_2948 9070189 9.45 µM 0.476286752109991 0.303156318763662 no 1013 0.316935051106668 1588 6473636 YDL196W YDL196W SGTC_481 bay k-8644 50 µM 0.475267455081408 0.303505489384867 no 1014 0.31729817641916 1473 2303 A calcium channel antagonist. SGTC_2498 4'-Methoxychalcone 54.63 µM 0.474608033209197 0.303731476738095 no 1015 0.317533189698955 1417 641818 YHR062C RPP1 SGTC_138 0850-0259 40.9225 µM 0.473827211454711 0.303999165526483 no 1016 0.31781156415372 1499 6813004 SGTC_332 4112-0506 40.9 µM 0.473134049836592 0.304236889917239 no 1017 0.31805877279575 1551 2790355 SGTC_874 0599-0792 117 µM 0.472240908708803 0.304543320628782 no 1018 0.318377421520809 1644 765305 SGTC_1976 st070609 63.5 µM 0.470947229073555 0.304987416719463 no 1019 0.318839209929804 1490 682556 SGTC_833 3852-0053 558 µM 0.470821844450513 0.305030474208099 no 1020 0.318883981857998 1581 3123681 SGTC_2946 9065502 71.43 µM 0.470365638578902 0.305187159566966 no 1021 0.319046904647693 1432 16489101 SGTC_126 0417-1624 672.48 µM 0.46997659151205 0.305320807233744 no 1022 0.319185870933276 1571 41912 YDL195W SEC31 SGTC_2324 6149169 200 µM 0.468099548261971 0.305965984296383 no 1023 0.319856701150336 1551 2888231 SGTC_1460 k062-0059 9.15 µM 0.468067704725202 0.305976934755391 no 1024 0.319868086697521 1483 1373085 SGTC_2067 5224629 34.075 µM 0.467269453052835 0.30625149677813 no 1025 0.32015355426478 1497 2835000 SGTC_1138 3761-0006 1.03 µM 0.467025646469091 0.306335376784723 no 1026 0.320240764636851 1548 12061087 SGTC_2035 5154463 94.595 µM 0.465388485950924 0.306898893547663 no 1027 0.320826639073076 1591 2769623 SGTC_2725 haloperidol 53.21 µM 0.465181261259849 0.306970253639044 no 1028 0.320900828387348 1502 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3063 1327-0034 4 µM 0.464495366982203 0.307206500996965 no 1029 0.32114643905341 1491 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2137 5261020 140 µM 0.46434909777388 0.30725689187984 no 1030 0.321198826462483 1512 763655 SGTC_1560 lithocholic acid 53.1 µM 0.463363279358817 0.307596608894795 no 1031 0.321551997451427 1548 9903 A bile acid which acts as a detergent. SGTC_1625 st003711 30.1 µM 0.46238736909857 0.307933074118735 no 1032 0.321901777767286 1608 24207034 YER133W GLC7 SGTC_1137 ixabepilone 100 µM 0.462264558850251 0.307975426937599 no 1033 0.321945805920955 1492 154225 A novel microtubule stabilizer. SGTC_2611 pyromycin 23.93 µM 0.461802438012417 0.308134818640315 no 1034 0.322111501193462 1503 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2443 5493264 126.67 µM 0.461048071432848 0.308395087587383 no 1035 0.322382058314664 1642 5340055 SGTC_2705 st078069 42.8 µM 0.46092167509696 0.308438705839758 no 1036 0.32242740016401 1510 1530061 SGTC_1570 verbenone 133 µM 0.460695876211046 0.308516633758638 no 1037 0.322508407022112 1644 29025 A natural terpanoid with antifungal properties. SGTC_1246 0422-0085 105 µM 0.460546304967688 0.308568258673537 no 1038 0.322562071344601 1608 264295 SGTC_1306 1185-0270 9.02 µM 0.460425530604594 0.308609947029852 no 1039 0.322605406398355 1614 1548076 SGTC_2955 9076254 12.21 µM 0.460258506457786 0.308667603745325 no 1040 0.322665340309396 1603 16459619 SGTC_466 geldanamycin 89.2 µM 0.458287611236748 0.309348312467646 no 1041 0.323372911758978 1546 5288382 HSP90 inhibitor. SGTC_2863 9028737 58.44 µM 0.457384337333948 0.309660504606804 no 1042 0.323697410086798 1635 6460917 SGTC_1791 st048313 56.1 µM 0.4564100868931 0.309997381850303 no 1043 0.324047556818829 1633 1204976 SGTC_486 niguldipine 82 µM 0.456289282323874 0.310039164894576 no 1044 0.324090984977954 1560 1236 A calcium channel blocker. SGTC_1012 4112-3522 18 µM 0.456126977608204 0.310095305582908 no 1045 0.324149335836151 1644 3112398 SGTC_871 0574-0004 149 µM 0.455828730943362 0.310198479703294 no 1046 0.324256571024099 1546 9551173 SGTC_1499 4480-0877 67.3 µM 0.454155650909269 0.31077753437701 no 1047 0.324858400393691 1545 2861909 SGTC_2104 5389443 200 µM 0.452803753741195 0.311245770017463 no 1048 0.325345030199019 1618 2244536 SGTC_1344 1488-0097 29.1 µM 0.451387334922568 0.311736680859271 no 1049 0.325855204899014 1561 747966 SGTC_2640 pentamidine 10.38 µM 0.451359238589291 0.311746422041777 no 1050 0.325865328117284 1637 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1776 st049249 45.9 µM 0.450354616828575 0.312094817491122 no 1051 0.326227381562924 1502 1822314 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.449821426658766 0.312279792246174 no 1052 0.326419603378683 1582 2724278 An inhibitor of dopamine biosynthesis. SGTC_2639 lactacystin 53 µM 0.449515141068433 0.312386070488878 no 1053 0.326530044070293 1634 3870 A proteasome inhibitor. SGTC_462 ag-879 158 µM 0.448564698519842 0.312715964527523 no 1054 0.326872852140581 1635 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2187 6125751 200 µM 0.446084043078573 0.313577694633349 no 1055 0.32776826939028 1570 874498 SGTC_588 3970-1144 52.9 µM 0.445188595164207 0.313889005731216 no 1056 0.328091733974689 1610 1888707 SGTC_1800 st050079 29.0735 µM 0.445088646682085 0.313923762009899 no 1057 0.328127846585887 1535 3645560 SGTC_1024 4507-0395 26 µM 0.444073238876852 0.314276955425925 no 1058 0.32849481688441 1590 4201836 SGTC_179 1273-0063 6.77 µM 0.44370051322912 0.314406644800134 no 1059 0.328629562180792 1508 3108139 SGTC_1096 rimcazole 32.2 µM 0.441661711546042 0.315116448075737 no 1060 0.329367010159143 1555 18528119 A dopamine reuptake inhibitor. SGTC_2152 5568786 200 µM 0.441481064461996 0.315179372853969 no 1061 0.329432383473403 1552 5399883 SGTC_944 3370-0224 231 µM 0.440724878727646 0.315442833137639 no 1062 0.329706091668691 1537 4580514 SGTC_682 0kpi-0099 17 µM 0.437263666522737 0.31664993948366 no 1063 0.330960070992745 1553 1714895 YML126C ERG13 SGTC_88 0180-0332 8.668 µM 0.434765400053313 0.317522431992305 no 1064 0.331866360933417 1613 3101745 SGTC_167 3672-0051 66.205 µM 0.433891045438162 0.317828030824417 no 1065 0.33218378129904 1513 3237971 SGTC_1674 st016616 23.6 µM 0.431736590481614 0.31858157155479 no 1066 0.33296643510424 1519 625830 SGTC_973 1325-0077 65.9 µM 0.431682033688158 0.318600663064003 no 1067 0.33298626354368 1697 2835149 SGTC_2645 abamectin 100 µM 0.430255260880649 0.319100116307425 no 1068 0.333504983837606 1635 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3027 9089541 49.47 µM 0.429553549066938 0.319345876742157 no 1069 0.333760216453702 1565 9943819 SGTC_2665 lovastatin 100 µM 0.428762666693341 0.319622962534242 no 1070 0.334047975174937 1571 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2119 5528445 120.635 µM 0.428714221482868 0.319639938598277 no 1071 0.334065604903824 1645 791935 SGTC_3313 9133968 57.047 µM 0.428531551246085 0.319703952899313 no 1072 0.334132083844692 1567 1494643 SGTC_139 0099-0334 718.624 µM 0.42795225584903 0.319906994614374 no 1073 0.334342940474675 1626 97690 SGTC_2736 butenafine 14.65 µM 0.427781327279022 0.319966915001747 no 1074 0.334405166431196 1667 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2322 7413319 38.22 µM 0.426519841079761 0.320409284322535 no 1075 0.334864546741563 1620 1840400 SGTC_2539 epi(13)torulosol 80 µM 0.426304493431069 0.320484826485066 no 1076 0.334942992035547 1548 6708597 SGTC_2177 5811945 192 µM 0.425797280658958 0.320662781888349 no 1077 0.335127784311817 1670 5343475 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.425080872516252 0.320914203636413 no 1078 0.335388860502123 1545 4174840 SGTC_3059 1327-0034 3 µM 0.423403608763387 0.321503156532635 no 1079 0.336000406184247 1545 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1963 st076565 50.3 µM 0.422557066354753 0.321800581267885 no 1080 0.336309228338435 1574 4914280 SGTC_1150 3909-7983 10.9 µM 0.422236174748547 0.321913353388461 no 1081 0.336426319805772 1558 23965914 SGTC_2318 6029776 164 µM 0.422045690711319 0.32198030365568 no 1082 0.33649583382022 1674 818325 SGTC_2724 maprotiline 69.64 µM 0.42199811816371 0.321997025091296 no 1083 0.336513195510776 1652 4011 A tricyclic antidepressant. SGTC_739 1486-1183 203 µM 0.421713402233079 0.322097108388337 no 1084 0.336617110408328 1706 4346692 SGTC_317 4495-0002 170 µM 0.421410136553165 0.322203726481069 no 1085 0.336727809269667 1572 15991618 SGTC_3207 9114163 49.47 µM 0.421248484600227 0.322260563891789 no 1086 0.336786821685363 1775 849233 SGTC_512 prima-1 270 µM 0.420816452466486 0.322412488344659 no 1087 0.3369445583968 1658 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2094 5332512 191.667 µM 0.417827702659687 0.323464295933487 no 1088 0.338036547428266 1700 755774 SGTC_2520 obtusaquinone 4.71 µM 0.416745501300924 0.323845495389144 no 1089 0.338432284453578 1689 5967872 SGTC_1290 0986-0249 10.2 µM 0.416539351787136 0.323918131388908 no 1090 0.338507689010525 1604 53329 SGTC_602 3130-1533 38.1 µM 0.416297881190733 0.324003221165466 no 1091 0.338596021408152 1685 720941 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.415891561975631 0.32414642130448 no 1092 0.338744677145821 1569 390807 SGTC_1986 st071812 45 µM 0.41584372904893 0.324163280899695 no 1093 0.338762178928846 1602 11838594 SGTC_2918 7977171 22.06 µM 0.415391469739284 0.324322705833956 no 1094 0.338927675119031 1579 2236483 SGTC_2605 digitonin 300 nM 0.41480954300597 0.324527886930162 no 1095 0.339140666519594 1685 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_987 1497-1013 404 µM 0.414248605355459 0.324725717930549 no 1096 0.339346024363765 1641 1676435 SGTC_2625 euphol 100 µM 0.413380114670988 0.325032114009503 no 1097 0.339664070717335 1744 6708538 A triterpene alcohol. SGTC_3289 9119912 71.43 µM 0.412945155432005 0.325185608404655 no 1098 0.339823398260304 1621 17014829 SGTC_2045 5106652 78.05 µM 0.412653066397849 0.325288701450934 no 1099 0.339930407863309 1676 673349 SGTC_279 1273-0055 2.93 µM 0.412219646113429 0.32544170211116 no 1100 0.340089219285968 1686 2847562 SGTC_2642 cholecalciferol 100 µM 0.410061070045736 0.326204133625121 no 1101 0.34088057467986 1657 9821465 A vitamin D precursor, similar to steriods. SGTC_2277 7947813 106.88 µM 0.409093432097156 0.326546149590782 no 1102 0.341235548013192 1714 1246798 SGTC_1897 st060201 15 µM 0.409089708007728 0.326547466168786 no 1103 0.341236914449183 1565 611878 SGTC_699 0375-0592 111 µM 0.408989833436623 0.326582775649697 no 1104 0.341273561018202 1675 762578 SGTC_2278 7948257 134.34 µM 0.408223746847293 0.326853668203575 no 1105 0.341554707802276 1766 1247028 SGTC_192 3455-0609 60.9 µM 0.407085760643995 0.327256235046625 no 1106 0.341972500643137 1644 3769639 SGTC_2641 levomentholum 100 µM 0.406746732497043 0.32737620639696 no 1107 0.342097006677092 1621 16666 SGTC_2669 eugenol 100 µM 0.404434647762227 0.32819485507164 no 1108 0.342946563013343 1706 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1328 1441-0025 69.2 µM 0.40424117847409 0.328263394978078 no 1109 0.343017687784412 1526 4562601 SGTC_1323 1348-1351 11.2 µM 0.403505137145538 0.328524203416607 no 1110 0.343288328171349 1599 6989654 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.40307572560116 0.328676399450152 no 1111 0.343446258763184 1775 551469 SGTC_90 0870-0863 4.608 µM 0.403020169280728 0.328696092314945 no 1112 0.343466693473305 1595 1738164 SGTC_1837 st055472 66.5 µM 0.402986897509 0.328707886277369 no 1113 0.343478931706067 1677 676091 SGTC_890 0929-0006 47.2 µM 0.402627520569337 0.328835286761833 no 1114 0.343611130452804 1571 1378169 SGTC_2121 5257820 149.641 µM 0.402068520579688 0.329033493902322 no 1115 0.343816799630769 1752 791256 SGTC_1760 st045453 10.4495 µM 0.402039712414271 0.329043709846263 no 1116 0.343827400082103 1686 3323419 YIL048W NEO1 SGTC_3011 9081274 71.4286 µM 0.401963902002202 0.329070594324501 no 1117 0.343855296391089 1610 6625322 SGTC_1241 0364-0022 50.8 µM 0.401401525716711 0.329270056176996 no 1118 0.344062263135931 1667 4563895 SGTC_702 1488-0190 94 µM 0.400540646024353 0.329575484412225 no 1119 0.344379176139513 1754 949357 SGTC_3215 9129942 49.47 µM 0.399220003297285 0.330044251206847 no 1120 0.34486555267108 1737 17682944 SGTC_6 0844-0013 19.835 µM 0.39877378649756 0.330202697811017 no 1121 0.345029946859327 1691 1584900 SGTC_1187 1391-0724 117 µM 0.398657388695296 0.33024403438062 no 1122 0.345072834687523 1663 6997986 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.398263657135902 0.330383876362547 no 1123 0.345217923408333 1812 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2931 9014674 55.67 µM 0.398134914722896 0.330429607058333 no 1124 0.345265369480356 1562 2996810 SGTC_2129 girgensonine 121.053 µM 0.395876842185945 0.331232110009852 no 1125 0.346097942827526 1704 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3168 9103419 49.47 µM 0.395514079782386 0.331361105608645 no 1126 0.34623176637169 1656 16649256 SGTC_1185 1319-0113 81.3 µM 0.395136255206318 0.331495478477289 no 1127 0.346371166786105 1688 4672763 SGTC_2041 5107442 45.335 µM 0.394071953958756 0.331874112537566 no 1128 0.346763958304869 1723 793005 SGTC_989 1501-0895 10.3 µM 0.393873036158298 0.33194489827131 no 1129 0.346837389289343 1753 2830112 SGTC_404 fumagillin 50 µM 0.392676242146356 0.332370908982999 no 1130 0.347279310031345 1670 12015870 A methionine aminopeptidase binder. SGTC_2939 9044578 71.43 µM 0.391357817815259 0.33284046601566 no 1131 0.347766383681308 1591 2653634 SGTC_2161 5662504 8.5105 µM 0.391254769786457 0.332877177647926 no 1132 0.347804463952718 1616 2859334 SGTC_1614 st002383 48.6 µM 0.390855872190437 0.33301930300689 no 1133 0.347951886666118 1644 1947235 SGTC_1270 0831-1170 17.3 µM 0.390165031504712 0.33326550307236 no 1134 0.348207258711798 1625 6764716 SGTC_3177 9107506 49.47 µM 0.389947213063533 0.333343143565739 no 1135 0.348287790456676 1725 8897194 SGTC_3128 9127691 49.47 µM 0.388782993606994 0.33375824585061 no 1136 0.348718341108081 1655 41316314 SGTC_3320 9137005 35.139 µM 0.388241213576023 0.333951486879394 no 1137 0.348918768230454 1649 4908713 SGTC_2766 oltipraz 83.91 µM 0.387648492459402 0.334162947917555 no 1138 0.349138088887392 1723 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_668 1682-0499 62.6 µM 0.386812155251849 0.334461411740809 no 1139 0.349447638899859 1637 682214 SGTC_790 1575-0012 79.1 µM 0.386520086082071 0.334565667189064 no 1140 0.349555764852563 1736 378741 YLR208W SEC13 SGTC_27 0485-0001 32.618 µM 0.384782083234615 0.335186318982347 no 1141 0.350199437267534 1698 2054479 SGTC_153 4077-0274 519.67 µM 0.384458991297097 0.335301746831174 no 1142 0.35031914244954 1779 3121976 SGTC_2662 daunorubicin 22.37 µM 0.380591999574908 0.336684472801443 no 1143 0.351753009362428 1632 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_925 2064-1272 59.6 µM 0.380453327664135 0.336734099092881 no 1144 0.351804467751727 1624 6815817 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.380277287686532 0.336797102329053 no 1145 0.351869796598526 1802 688664 SGTC_1825 st052143 62.6 µM 0.380189647676831 0.33682846966359 no 1146 0.351902321641543 1726 674173 SGTC_224 benfluorex 43.875 µM 0.379027831072175 0.337244403933954 no 1147 0.352333598444755 1763 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2944 9067346 25.62 µM 0.377894449610794 0.337650350103119 no 1148 0.352754502912526 1688 6473075 SGTC_2249 haloperidol 116.36 µM 0.377567257781265 0.337767576418585 no 1149 0.352876045874599 1711 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1846 st056244 14.8 µM 0.375424746941068 0.33853558391042 no 1150 0.353672301596409 1699 5393182 SGTC_2864 9034755 47.6 µM 0.374055713964342 0.339026681546422 no 1151 0.35418143302503 1677 4930451 SGTC_2803 7707263 71.43 µM 0.373434433226469 0.339249636851183 no 1152 0.354412567992945 1632 2199229 SGTC_2700 st077718 96.8 µM 0.372632317559077 0.339537570556946 no 1153 0.354711058256767 1632 904970 SGTC_3133 9127736 49.47 µM 0.371252959953636 0.340032934543932 no 1154 0.355224565380254 1835 27243420 SGTC_2248 tofa 1.1 µM 0.371042444652572 0.340108560506889 no 1155 0.355302959153111 1694 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1565 sinapyl alcohol 95.1 µM 0.370397823795034 0.340340175469085 no 1156 0.355543047524357 1606 5280507 A phenol propionate derived from cinnamic acid. SGTC_3226 9131256 49.47 µM 0.370145476687859 0.34043086124923 no 1157 0.355637049562669 1642 17178073 SGTC_182 3448-4371 550.524 µM 0.368825537071813 0.340905357164021 no 1158 0.356128884370331 1851 3491403 SGTC_2239 6685329 187.64 µM 0.368796117848422 0.340915935747229 no 1159 0.356139849268238 1656 805680 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.368608449842382 0.34098342047276 no 1160 0.356209798187784 1645 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2969 9091408 28.7 µM 0.367627119991219 0.341336385902616 no 1161 0.356575645008473 1592 4286311 SGTC_1738 st035555 74 µM 0.365947130446442 0.34194096792917 no 1162 0.357202263454544 1685 5331140 SGTC_2667 digitoxin 100 µM 0.365135678419813 0.342233132535903 no 1163 0.357505064644727 1773 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_136 0097-0015 404.482 µM 0.363436042675127 0.34284539508667 no 1164 0.358139590799613 1750 4861337 SGTC_1347 1493-0251 600 nM 0.363081903425788 0.342973019286202 no 1165 0.358271851253896 1794 3986378 SGTC_2389 9091542 195.52 µM 0.362992794793482 0.343005134950528 no 1166 0.358305133350777 1654 3626624 YOL127W RPL25 SGTC_3052 9092717 49.47 µM 0.362329086722775 0.343244377813905 no 1167 0.358553062340184 1671 25237534 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.362311043848618 0.343250882498178 no 1168 0.358559803111623 1675 3256 An antibiotic and ribosome inhibitor. SGTC_1787 fluconazole 80 µM 0.360889694954287 0.343763442527892 no 1169 0.359090953716131 1642 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_74 000s-0487 160.283 µM 0.360415164649378 0.343934629395745 no 1170 0.359268343921126 1619 677548 SGTC_1422 4031-0024 15.5 µM 0.360031352125716 0.3440731132204 no 1171 0.359411843955861 1746 782427 SGTC_2217 6934799 96.0675 µM 0.35996279274099 0.344097852410725 no 1172 0.359437479063921 1749 675606 SGTC_1868 st057644 42.7 µM 0.359860142221905 0.344134894403813 no 1173 0.359475862404812 1655 688665 SGTC_1268 0828-0275 2.46 µM 0.359766143003577 0.344168815840238 no 1174 0.359511012073208 1737 745337 SGTC_2595 hexamethylquercetagetin 100 µM 0.35945971278004 0.344279405819633 no 1175 0.359625605541646 1688 386331 SGTC_259 usnic acid 108.925 µM 0.35845141317236 0.344643392838953 no 1176 0.360002761021602 1748 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2876 9059903 25.97 µM 0.356356122408174 0.345400233634864 no 1177 0.360786942281857 1693 6916095 SGTC_3068 9116768 49.47 µM 0.35603042306105 0.345517935247641 no 1178 0.360908890845569 1682 41904888 SGTC_2378 9074213 121.43 µM 0.355595911912083 0.345674982653082 no 1179 0.361071602811667 1668 657714 SGTC_2759 disulfiram 3.38 µM 0.354295264794554 0.346145240312788 no 1180 0.361558808027541 1652 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2828 7998861 71.43 µM 0.352934833695681 0.346637367237063 no 1181 0.362068647803087 1827 2988188 SGTC_2949 9072542 2.23 µM 0.351829547540761 0.347037387856519 no 1182 0.362483048910072 1640 16457352 SGTC_2623 humulene 100 µM 0.351491527694958 0.347159756677059 no 1183 0.362609813723252 1662 6187145 An anti-inflammatory. SGTC_750 4073-0104 132 µM 0.35048098888645 0.34752568357569 no 1184 0.362988877585967 1656 22330957 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.348683094673351 0.348177071485444 no 1185 0.363663618593048 1825 756377 SGTC_362 0310-0100 9.03 µM 0.348256780883467 0.348331593344135 no 1186 0.363823674229475 1685 790235 SGTC_2406 ethylparaben 405.7 µM 0.347943297095262 0.348445234862687 no 1187 0.363941384031566 1479 8434 A possible steroid mimic. SGTC_519 k048-0011 62.8 µM 0.347708180179336 0.348530476407669 no 1188 0.364029676340082 1741 6836379 SGTC_766 1391-0721 126 µM 0.347628220968417 0.348559467331202 no 1189 0.364059704677573 1804 1020919 YIL115C NUP159 SGTC_266 formosanin C 406 nM 0.347501392958966 0.348605453355042 no 1190 0.364107336102504 1733 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_414 piperonyl butoxide 100 µM 0.347227404874181 0.348704805112999 no 1191 0.364210242011978 1665 5794 A potent inhibitor of cytochrome P450. SGTC_1849 st056239 19.2 µM 0.346553286699745 0.348949293574371 no 1192 0.364463472583268 1605 5393181 SGTC_1575 cyproterone acetate 48 µM 0.346283734884831 0.349047071899689 no 1193 0.364564745519075 1640 9880 An androgen receptor antagonist and liver toxin. SGTC_2050 5263056 171 µM 0.341172461618468 0.350903046445662 no 1194 0.366486876677418 1842 763468 YGL055W OLE1 SGTC_1293 1000-1278 195 µM 0.340133230567192 0.35128084303196 no 1195 0.366878098840689 1778 678847 SGTC_1212 0520-0165 585 µM 0.338777620801259 0.351773875176 no 1196 0.367388630703151 1888 5403258 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.337494356991872 0.352240825066987 no 1197 0.367872132675971 1852 6728940 SGTC_400 oxethazaine 37.5 µM 0.337388471357241 0.35227936435148 no 1198 0.367912037120343 1712 4621 A local anesthetic. SGTC_704 1310-0270 142 µM 0.335911118250914 0.352817235891689 no 1199 0.368468946296633 1667 5718033 SGTC_1817 st052116 64.4 µM 0.333721504093201 0.353614967017622 no 1200 0.369294860527911 1791 4361398 SGTC_2915 7971052 15.16 µM 0.333488438099299 0.353699916723135 no 1201 0.36938280775791 1775 5741558 SGTC_539 4859-0462 2.54 µM 0.333390714680836 0.353735537882624 no 1202 0.369419685630741 1859 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2567 aureobasidin a 60 nM 0.332320183399636 0.354125840993731 no 1203 0.369823750477989 1766 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3114 9122766 49.47 µM 0.332246914608532 0.354152559542808 no 1204 0.369851410552968 1689 17176985 SGTC_3065 9113888 49.47 µM 0.331428046506461 0.354451220745326 no 1205 0.370160591411551 1797 16648368 SGTC_3125 9127534 49.47 µM 0.33073374130737 0.354704520952731 no 1206 0.370422806680008 1754 1639235 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.330413136172867 0.354821507558387 no 1207 0.370543908577486 1604 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_513 4245-1575 41.7 µM 0.329930994941361 0.354997463347284 no 1208 0.370726051513996 1819 719745 SGTC_156 3474-0145 5.642 µM 0.329517947098881 0.355148228341271 no 1209 0.370882115450813 1873 2265471 SGTC_320 4092-0846 5.34 µM 0.328870965842404 0.35538442604043 no 1210 0.371126610309381 1797 1359356 SGTC_2125 5246583 200 µM 0.328576226599401 0.355492046858965 no 1211 0.371238009816788 1893 835267 SGTC_627 1391-0720 175 µM 0.326612246209861 0.356209466709443 no 1212 0.371980589984899 1742 997839 SGTC_2582 agaric acid 100 µM 0.325344737884179 0.356672743763245 no 1213 0.372460087504948 1670 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_880 0833-0487 87.2 µM 0.324620213294737 0.356937654133767 no 1214 0.372734263534458 1695 76075 SGTC_551 k048-0028 34.9 µM 0.321492024816474 0.358082214865993 no 1215 0.373918777517607 1840 6836383 SGTC_932 2857-0803 154 µM 0.3206840030972 0.358378066687979 no 1216 0.374224935614331 1860 674898 SGTC_2603 homopterocarpin 100 µM 0.319341199737816 0.3588699132842 no 1217 0.374733896991428 1732 101795 A weak amylase inhibitor. SGTC_933 2914-0560 114 µM 0.319024911416461 0.358985798542719 no 1218 0.37485381122398 1905 463887 SGTC_2296 7971656 126.45 µM 0.317158696677482 0.359669827096116 no 1219 0.375561594254803 1715 666570 SGTC_3236 9132701 49.47 µM 0.316901049397791 0.359764298610473 no 1220 0.375659342867917 1720 24282524 SGTC_2531 methyl deoxycholate 70.07 µM 0.316654250649197 0.359854800330017 no 1221 0.375752983149175 1706 16667744 Haematoxylin. SGTC_1808 st050063 61.5 µM 0.3166413770998 0.359859521308515 no 1222 0.375757867826943 1838 4011993 SGTC_3347 9188721 44.724 µM 0.315993512629486 0.36009713328519 no 1223 0.376003716110415 1805 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_967 1306-0166 352 µM 0.315240400334861 0.360373414095977 no 1224 0.376289566557064 1886 4437607 SGTC_994 3910-0338 138 µM 0.314494754864609 0.360647027531986 no 1225 0.376572649770974 1831 3479481 SGTC_2505 galangin 7.89 µM 0.310857069078983 0.361982891517031 no 1226 0.377954641254157 1716 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_283 0987-0079 11.7 µM 0.310784182580111 0.362009674812223 no 1227 0.37798234756338 1872 411556 SGTC_791 1348-1292 225 µM 0.309073438275743 0.362638508637742 no 1228 0.378632831916022 1852 5437054 SGTC_1848 st056003 16.4 µM 0.303660853670535 0.36463049613077 no 1229 0.380693142357691 1950 146492 SGTC_3286 9117135 37.221 µM 0.301382678458524 0.365470028248284 no 1230 0.381561350617688 1703 3438150 SGTC_1876 myriocin 605 nM 0.300875135550507 0.365657151268327 no 1231 0.381754855627547 1897 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2541 muurolladie-3-one 83.07 µM 0.300052903216174 0.365960363127132 no 1232 0.38206840132912 1819 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_606 k015-0008 38.6 µM 0.299633687557933 0.366114988121375 no 1233 0.382228292586727 1887 1970475 SGTC_2681 menadione 3.18 µM 0.298499139841501 0.366533567730079 no 1234 0.382661116258634 1801 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_176 1486-1328 72.834 µM 0.297414314505131 0.366933951313524 no 1235 0.383075108233473 1726 22310231 SGTC_2773 thioridazine 9.09 µM 0.296433601797824 0.367296033997997 no 1236 0.383449483646267 1842 5452 An antipsychotic. SGTC_841 0251-0215 91.2 µM 0.295908736412145 0.36748986471102 no 1237 0.383649889503622 1834 3888614 SGTC_299 1273-0059 1.44 µM 0.295219041622389 0.367744617599434 no 1238 0.383913278393433 1858 2848077 SGTC_1856 st057054 55.7 µM 0.293728157847367 0.368295504779769 no 1239 0.384482818037455 1912 1266018 SGTC_710 3448-4187 58 µM 0.29296995520998 0.368575767498756 no 1240 0.384772558420743 1776 3946412 SGTC_1219 1469-0211 33.1 µM 0.289942563797403 0.36969551089952 no 1241 0.385930089168462 1898 6822282 SGTC_2301 7769476 200 µM 0.289876109120296 0.369720102976328 no 1242 0.385955509718994 1822 977820 SGTC_802 4112-3352 742 µM 0.288300367990255 0.370303374308119 no 1243 0.386558412746158 1906 704594 SGTC_3214 9129694 49.47 µM 0.288191360474604 0.370343735232202 no 1244 0.386600130861619 1911 17158655 SGTC_3139 9095020 49.47 µM 0.286657244369542 0.370911905483692 no 1245 0.38718738911567 1800 25236292 SGTC_206 4546-0025 72.014 µM 0.286423242365143 0.37099859448426 no 1246 0.387276987607743 1817 6620745 YIL048W NEO1 SGTC_20 0481-0013 4.944 µM 0.286396955296723 0.371008333270187 no 1247 0.387287053203191 1758 182045 SGTC_1094 duloxetine 25.4 µM 0.285056325701394 0.371505116738126 no 1248 0.387800494740421 1820 60834 A selective serotonin reuptake inhibitor. SGTC_3213 9129884 49.47 µM 0.283948403217222 0.371915829927747 no 1249 0.388224961002957 1691 17190742 SGTC_3281 9140613 49.47 µM 0.28388138392891 0.371940679041541 no 1250 0.388250641660826 1711 16013766 SGTC_2028 5153890 36.43 µM 0.281086335974329 0.372977488359186 no 1251 0.389322090583096 1797 2830968 YPR165W RHO1 SGTC_1845 st056753 3.01 µM 0.279447004025457 0.373586019367364 no 1252 0.389950901592804 1725 5375839 SGTC_1638 st008370 60.6 µM 0.279148542616876 0.373696844218134 no 1253 0.390065415752438 1804 24207134 SGTC_1355 1499-0035 1.68 µM 0.276416572163492 0.374711765243585 no 1254 0.391114064818305 1796 1548538 SGTC_1469 k284-2957 126 µM 0.275522797720242 0.375043989368414 no 1255 0.391457306649265 1876 23884841 SGTC_1751 st044839 27.194 µM 0.27398390190039 0.375616228168977 no 1256 0.392048496446697 1920 5291326 SGTC_3180 9109287 49.47 µM 0.272548194364993 0.376150343235326 no 1257 0.392600269752206 1829 18891271 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.272077333546018 0.376325565635213 no 1258 0.392781278776277 1926 6708630 An antioxidant. SGTC_1190 1486-1332 13 µM 0.272057047326079 0.376333115360789 no 1259 0.392789077756804 1820 4150046 SGTC_531 3788-1495 174 µM 0.27039375524662 0.376952287362916 no 1260 0.393428671915833 1786 2896655 SGTC_1860 st056228 74.6 µM 0.269382047959862 0.377329057358155 no 1261 0.393817849694276 1789 688679 SGTC_1331 1472-0049 76.2 µM 0.26897080191743 0.377482242938127 no 1262 0.393976075816806 1784 24051409 SGTC_1153 4055-0057 267 µM 0.268299867801181 0.377732201438791 no 1263 0.39423425398541 1782 882706 SGTC_1393 3470-5649 58.2 µM 0.268131672009545 0.377794871313115 no 1264 0.394298983698706 1832 4108395 SGTC_542 3381-0244 89.3 µM 0.266904729063849 0.378252128368897 no 1265 0.394771257714633 1946 1112843 SGTC_2398 5228213 48.84 µM 0.266033443765335 0.378576942553882 no 1266 0.395106726202612 2012 80771 YMR134W ERG29 SGTC_2233 sulbentine 40.3845 µM 0.264604696097044 0.379109763701952 no 1267 0.39565700104476 1891 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2924 9010168 62.78 µM 0.264131795360678 0.379286172664854 no 1268 0.395839182223635 1839 2993929 SGTC_1064 honokiol 6.76 µM 0.263310920549884 0.379592448129696 no 1269 0.396155471611017 1857 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_578 3460-0051 92 µM 0.263116186794484 0.379665116068001 no 1270 0.396230514068009 1963 2876744 SGTC_1788 fluconazole 20 µM 0.26259800390059 0.379858504793604 no 1271 0.396430219369442 1801 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1266 0828-0227 32.9 µM 0.261911250938236 0.380114851098136 no 1272 0.396694932666454 1890 3913820 SGTC_1660 st012960 28.1 µM 0.26152847644224 0.380257753332476 no 1273 0.396842496204592 1842 24207266 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.260377493880653 0.38068755115504 no 1274 0.39728630083459 1931 6710655 SGTC_3346 9158254 43.5805 µM 0.259892390586689 0.380868741700772 no 1275 0.397473390539845 1846 17639500 SGTC_1864 st057645 30.4 µM 0.259780119457531 0.38091067972567 no 1276 0.397516693490127 1978 688666 SGTC_1165 k072-0275 30.3 µM 0.259285166864593 0.381095582169053 no 1277 0.397707611648682 1949 6153523 YGL055W OLE1 SGTC_383 2324-0395 7.37 µM 0.258511971225282 0.381384483878399 no 1278 0.398005905570891 1909 3146421 SGTC_2536 dehydroabietamide 32.04 µM 0.257851841724747 0.381631191161218 no 1279 0.398260626494885 1952 3983547 SGTC_1539 benzyladenosine 56 µM 0.256280364458214 0.382218685767564 no 1280 0.398867178984681 1849 92208 A nucleotide analog. SGTC_2336 9001819 198.65 µM 0.256027149407839 0.38231337527573 no 1281 0.398964936807047 1911 2989602 SGTC_837 0091-0265 12.5 µM 0.255511150227918 0.382506354418177 no 1282 0.399164166362244 1838 759367 SGTC_2358 9037157 4 µM 0.254219439036227 0.382989570873396 no 1283 0.399663016819559 1881 2388925 SGTC_1285 0929-0069 65.5 µM 0.253318967324451 0.383326536286341 no 1284 0.400010870099379 1864 1206237 SGTC_128 0906-2981 13.371 µM 0.25294800981384 0.383465377943134 no 1285 0.40015419451612 1973 6740226 SGTC_1235 benzylparaben 21.5 µM 0.251104628989232 0.384155538570431 no 1286 0.400866608564267 1877 7180 SGTC_3209 9113616 49.47 µM 0.251017108475919 0.384188315350838 no 1287 0.400900440963155 2026 16649353 SGTC_491 tetrandrine 80.3 µM 0.250601322322531 0.384344040229252 no 1288 0.401061179637011 1945 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_723 4182-0001 115 µM 0.250164327482778 0.384507728543272 no 1289 0.401230135424215 1826 744821 YLR208W SEC13 SGTC_793 0488-0545 106 µM 0.247287022203448 0.385586014512798 no 1290 0.402343050872221 1824 292548 SGTC_62 0180-0423 3.232 µM 0.2443268626108 0.386696274099552 no 1291 0.403488840213588 1927 30102 YGL099W LSG1 SGTC_632 0781-2353 4.65 µM 0.244153350341114 0.386761381788063 no 1292 0.403556027441347 1916 6811515 YHR007C ERG11 SGTC_2006 4011487 200 µM 0.243261824842556 0.387095962613722 no 1293 0.403901287794854 1959 45595294 SGTC_2512 diallyl trisulfide 49.23 µM 0.243193980939021 0.387121427207641 no 1294 0.403927564717561 1973 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_556 4058-0063 51.5 µM 0.242812916419374 0.387264465343735 no 1295 0.404075164557356 1867 6615692 SGTC_3194 9111903 49.47 µM 0.240975232813522 0.387954481327707 no 1296 0.404787156155011 1916 17087251 SGTC_107 0358-0022 2.6945 µM 0.240105172152839 0.388281296495896 no 1297 0.405124362342886 1981 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1284 0929-0043 16 µM 0.24004016522853 0.388305717799084 no 1298 0.405149559667318 1872 1239883 SGTC_2315 7733312 200 µM 0.239461165737795 0.388523251363277 no 1299 0.405374002910491 1836 726316 SGTC_2737 bleomycin 30.5 nM 0.239031205676084 0.388684812553007 no 1300 0.405540692679712 1908 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1634 st006576 41 µM 0.237705687280146 0.389183008562138 no 1301 0.406054686140788 2025 3915356 SGTC_1013 4112-3890 241 µM 0.237173407601082 0.389383117175492 no 1302 0.406261132733918 1854 705171 SGTC_564 3555-0129 330 µM 0.236953132978955 0.38946593720543 no 1303 0.40634657466855 2009 563260 SGTC_3047 9092122 49.47 µM 0.236669183725395 0.389572705370524 no 1304 0.406456721822923 1855 17173831 SGTC_3049 9092223 49.47 µM 0.236393185298244 0.389676491922401 no 1305 0.40656379185547 1918 8623917 SGTC_1411 3909-8223 150 µM 0.235742163625531 0.389921333510754 no 1306 0.406816374982306 1991 X1411 SGTC_951 1171-0579 82.7 µM 0.235605480418514 0.389972744007752 no 1307 0.406869410205508 1874 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_906 1165-0455 526 µM 0.23546862558642 0.390024220986255 no 1308 0.406922513733081 1846 3252859 SGTC_3251 9135047 49.47 µM 0.235325514945047 0.390078053106199 no 1309 0.406978046521167 1984 17682963 SGTC_1829 berberine 14.4 µM 0.235074199809466 0.390172592243132 no 1310 0.407075571608386 1988 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2192 5915882 198.485 µM 0.234422822342369 0.390417656111246 no 1311 0.407328371268835 1898 2876149 SGTC_1038 k292-0204 154 µM 0.234406169797455 0.390423921770363 no 1312 0.407334834629706 1825 4454212 SGTC_2282 7944268 200 µM 0.233778106689423 0.390660256524452 no 1313 0.407578623493551 1952 2970414 SGTC_410 α-linolenic acid 100 µM 0.233399506838969 0.39080273991859 no 1314 0.40772559804312 1967 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2844 9010103 25.97 µM 0.232778954642561 0.391036312080916 no 1315 0.407966527908929 1876 2480525 SGTC_1406 3909-7906 11.9 µM 0.232747813253362 0.391048034551434 no 1316 0.40797861949503 1950 X1406 SGTC_412 gemfibrozil 100 µM 0.232113294350074 0.391286906360667 no 1317 0.408225009717388 1992 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1405 3909-7894 12 µM 0.232014697893459 0.391324027794063 no 1318 0.408263298996614 1991 7104060 SGTC_819 1013-0258 27.7 µM 0.231503674222346 0.39151644337316 no 1319 0.408461765672941 1885 5753198 SGTC_2201 6605497 169.863 µM 0.229967682418925 0.392094949506733 no 1320 0.409058441208714 1983 670741 SGTC_2752 diclazuril 33.15 µM 0.227769865768248 0.392923135809207 no 1321 0.40991257729545 2021 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2621 lithochol-11-enic acid 100 µM 0.227594248716446 0.392989333200892 no 1322 0.409980845742801 2036 6708711 SGTC_920 mycophenolic acid 780.421 nM 0.225020263149829 0.393959929863959 no 1323 0.410981755375881 1860 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3300 9124615 50.48 µM 0.224440240389315 0.394178735636713 no 1324 0.411207380968464 1975 24824903 SGTC_1867 st057372 64 µM 0.222179553179189 0.395031867630389 no 1325 0.412087055273269 1991 688837 SGTC_767 0929-0023 86 µM 0.22157192283224 0.395261259538381 no 1326 0.412323570773457 1963 1204563 SGTC_2107 5363541 170.161 µM 0.220669155820122 0.395602138108264 no 1327 0.412675024758631 1997 244052 SGTC_3073 9114972 49.47 µM 0.220521475237772 0.395657908882238 no 1328 0.412732524591052 2043 41905075 SGTC_1196 1588-0294 184 µM 0.219131769932497 0.396182828084161 no 1329 0.413273701652762 1886 6144269 SGTC_1086 cerivastatin 2.18 µM 0.218938750443613 0.396255750278641 no 1330 0.413348880086558 2023 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_581 0958-0271 211 µM 0.218332959023869 0.396484640055651 no 1331 0.413584848125756 1872 4591145 SGTC_818 4072-2707 53.5 µM 0.2181179297742 0.396565894420684 no 1332 0.4136686138878 1905 882871 SGTC_2140 5586273 200 µM 0.217338810682474 0.396860342326844 no 1333 0.413972156660788 1992 854421 SGTC_1045 1348-1485 165 µM 0.216887900263314 0.397030779134667 no 1334 0.41414785368298 2015 6810614 SGTC_64 000l-0018 272.079 µM 0.216326499810517 0.397243006863631 no 1335 0.414366627103601 1855 6811119 SGTC_1937 st074714 47.2 µM 0.216314042875164 0.39724771633784 no 1336 0.414371481776673 1780 17250970 SGTC_456 gingerol 170 µM 0.214494611668144 0.397935731810845 no 1337 0.415080684228077 1962 442793 A herb. SGTC_2594 a-mangostin 100 µM 0.213746302947285 0.398218796025853 no 1338 0.415372450569305 2021 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_867 0518-0118 155 µM 0.212827523848272 0.398566417661476 no 1339 0.415730747300771 2080 6848158 SGTC_3105 9121040 49.47 µM 0.212699332228768 0.398614925584115 no 1340 0.415780743825613 2065 41448907 SGTC_319 1348-1596 45.5 µM 0.211978204831037 0.398887830562659 no 1341 0.416062018980003 2035 5380505 SGTC_3150 9097574 49.47 µM 0.211855111112579 0.398934419353313 no 1342 0.416110035884943 2032 17217476 SGTC_1496 4469-0713 57.4 µM 0.210687569853358 0.399376384534937 no 1343 0.416565537358443 2016 746691 SGTC_1461 k072-0203 53.8 µM 0.210308026965907 0.399520085846245 no 1344 0.416713635385628 2034 5418714 SGTC_1613 st002381 52.1 µM 0.210095003830026 0.399600745948808 no 1345 0.416796762414438 2082 551167 SGTC_2385 9074692 200 µM 0.209557046365317 0.399804459812465 no 1346 0.417006703609927 1896 17046906 SGTC_2890 9046729 58.44 µM 0.20920421632594 0.399938084391766 no 1347 0.417144410549885 1864 903329 SGTC_1062 mesoridazine 14.2 µM 0.207721873846542 0.400499608296339 no 1348 0.417723068666208 1971 4078 A neuroleptic. SGTC_2696 st077691 74.316 µM 0.20763843466933 0.400531221890536 no 1349 0.41775564590647 1955 757133 SGTC_2477 5967686 25.23 µM 0.2075645416972 0.400559219144445 no 1350 0.417784496483718 1909 776118 SGTC_936 3005-4620 401 µM 0.206230578362182 0.401064731259687 no 1351 0.418305401563562 2068 777207 SGTC_1635 st007035 42.4 µM 0.205989172573555 0.401156230926752 no 1352 0.418399684489474 1985 3716403 SGTC_1480 1070-0044 41.2 µM 0.205247482913874 0.401437386320778 no 1353 0.418689386517087 2034 3124987 SGTC_1513 0337-0559 19 µM 0.205081355664271 0.40150036787143 no 1354 0.418754281434388 1876 775073 SGTC_1966 st070145 16.1 µM 0.203753443446905 0.402003892903086 no 1355 0.419273088144487 1940 3748532 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.202205898471478 0.402590904720554 no 1356 0.419877881032238 1911 279621 SGTC_3107 9121808 49.47 µM 0.20218846402643 0.402597519174984 no 1357 0.4198846956329 2068 662681 SGTC_2400 5203494 178.7 µM 0.201106835964627 0.403007932517032 no 1358 0.420307518434412 1984 6777674 SGTC_2879 9041815 71.43 µM 0.201052490171263 0.403028556328188 no 1359 0.420328765359067 2061 4942971 SGTC_178 4092-0806 87.505 µM 0.200676719910641 0.403171165634422 no 1360 0.420475682111155 2035 2169044 SGTC_2096 5468907 200 µM 0.199610497323167 0.403575879911782 no 1361 0.420892608665859 2053 759785 SGTC_1123 mangostin 811.285 nM 0.19854993877464 0.403978546703803 no 1362 0.421307408441751 1911 5281650 An antioxidant. SGTC_769 0302-0231 76 µM 0.197551773112843 0.404357617498763 no 1363 0.421697885263601 2025 571869 YER009W NTF2 SGTC_2508 celastrol 40.54 µM 0.197435489813361 0.404401783954307 no 1364 0.421743379654874 2065 122724 Celastrol is a natural product and antioxidant. SGTC_3116 9124943 49.47 µM 0.195507784285805 0.405134137735609 no 1365 0.422497722144153 1844 41905195 YPL160W CDC60 SGTC_687 k029-0044 34.9 µM 0.195461018241015 0.405151908742865 no 1366 0.422516026000958 2094 5829338 SGTC_1260 0700-1617 7.75 µM 0.194256557989276 0.405609668607963 no 1367 0.4229874996706 1964 2853078 SGTC_2825 7998094 58.44 µM 0.193890991761119 0.405748629063844 no 1368 0.423130618692915 1966 2987815 SGTC_2460 5552655 174.22 µM 0.193807069516491 0.405780531590735 no 1369 0.423163475648299 1924 5401989 SGTC_1032 k061-1018 98.7 µM 0.191922283818822 0.406497185783459 no 1370 0.423901540973865 2106 4005393 SGTC_2720 fluspirilene 36.88 µM 0.191694786111584 0.406583708731449 no 1371 0.423990645164645 2039 3396 An atypical antipsychotic. SGTC_2738 aclarubicin 5.55 µM 0.191233585328588 0.40675912867198 no 1372 0.424171295926915 2028 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2024 5144227 134 µM 0.190630963161964 0.406988367108318 no 1373 0.424407364965007 2022 3475211 SGTC_1243 0416-0003 5.65 µM 0.19054178264409 0.407022294228895 no 1374 0.424442302525765 1934 2141977 SGTC_2880 9042983 58.44 µM 0.18974672022574 0.407324792203347 no 1375 0.424753804179904 1957 6464714 SGTC_654 1124-0271 80.9 µM 0.1890089333939 0.407605547947272 no 1376 0.425042907577541 1895 5403748 SGTC_1443 4112-3303 14 µM 0.188383651889388 0.407843528330599 no 1377 0.425287957084955 1965 704433 SGTC_1511 0906-3109 28.5 µM 0.188083731244363 0.407957689358226 no 1378 0.425405507043807 2061 2882180 SGTC_1048 3161-0300 24.5 µM 0.187325327317015 0.408246401133963 no 1379 0.425702783066907 2023 2165101 SGTC_583 1488-1091 88.9 µM 0.186391241567779 0.40860206050925 no 1380 0.42606898014935 2118 4303273 SGTC_1445 4239-0156 97.7 µM 0.186353327095251 0.408616498289304 no 1381 0.42608384541092 2070 4008346 SGTC_258 haloperidol 50.781 µM 0.18612184001569 0.408704650946837 no 1382 0.426174607647828 1910 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_89 0302-0250 142.109 µM 0.185288311118293 0.40902210554051 no 1383 0.426501452834269 2115 4203518 YLR208W SEC13 SGTC_2798 7813637 45.45 µM 0.184346085496659 0.409381029806269 no 1384 0.426870981195071 2001 956368 SGTC_744 1594-0068 283 µM 0.183670038482698 0.409638604847241 no 1385 0.427136157415004 1952 668392 SGTC_336 4111-0029 111 µM 0.183310830807016 0.409775479447043 no 1386 0.427277068317974 1955 3131175 SGTC_1501 4491-0275 38.4 µM 0.182156795860498 0.410215294024556 no 1387 0.427729838793006 2098 5104718 SGTC_3317 9138495 8.753 µM 0.180608317508505 0.410805612419277 no 1388 0.428337513412598 2118 17020139 SGTC_1194 1488-0194 225 µM 0.180352316229147 0.410903225964813 no 1389 0.428437993275041 1983 1391452 SGTC_1408 3909-7976 48.8 µM 0.17697077381341 0.412193127070424 no 1390 0.429765673162159 2003 24152374 SGTC_2923 7992654 58.14 µM 0.176566954367792 0.412347229114339 no 1391 0.429924276397098 1966 2985126 SGTC_794 k038-0031 316 µM 0.175602830046968 0.412715204410026 no 1392 0.430302989424425 2061 6624242 SGTC_695 3505-6186 243 µM 0.175003401188108 0.412944025856908 no 1393 0.430538480533908 2032 1819379 SGTC_725 1497-0963 19 µM 0.17493161273363 0.41297143182453 no 1394 0.430566684942939 2107 3549977 SGTC_2307 7538926 6.34 µM 0.174879378033472 0.412991373215532 no 1395 0.430587207251738 1962 96582 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.171905615750635 0.414127020878815 no 1396 0.431755865791093 2004 65057 A dermal irritant. YDR527W RBA50 SGTC_3244 9134489 49.47 µM 0.171317055950759 0.414351870966216 no 1397 0.431987235004985 1964 16584271 SGTC_3152 9099253 49.47 µM 0.1702168860522 0.414772248934804 no 1398 0.43241978617811 2059 25236131 SGTC_1871 st057448 67.3 µM 0.169851734669189 0.414911795891416 no 1399 0.432563369806778 2075 691747 SGTC_2021 4019055 173 µM 0.167913246501281 0.415652791656943 no 1400 0.433325764445518 2070 44827708 YER133W GLC7 SGTC_101 0490-5701 117.494 µM 0.165479335779949 0.416583589468439 no 1401 0.434283356630481 2119 4661669 SGTC_2060 5238662 140 µM 0.165255666482438 0.416669150627301 no 1402 0.434371375997509 1987 790130 SGTC_1122 capsaicin 818.572 nM 0.163935116847162 0.417174386374577 no 1403 0.43489111090791 2047 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2617 dihydrotanshinone i 20.83 µM 0.163747450132517 0.417246197850877 no 1404 0.434964980929027 2009 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1748 st037455 53.6035 µM 0.163721554904772 0.417256106988051 no 1405 0.434975174076395 2020 580690 SGTC_3055 9094636 49.47 µM 0.161210126078086 0.418217385852732 no 1406 0.435963952988863 2073 25236176 SGTC_2451 5856223 45.7 µM 0.160064313642594 0.418656121712406 no 1407 0.43641520612988 2006 2179896 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.159656765851699 0.418812197711423 no 1408 0.436575729889727 2045 7104 SGTC_338 4055-0136 114 µM 0.159356003045766 0.418927387137471 no 1409 0.436694200184689 2059 2900563 SGTC_2158 5657123 3.6195 µM 0.15928286988 0.418955397527366 no 1410 0.436723008154922 2133 2858827 SGTC_216 k038-0035 28.382 µM 0.159072551083101 0.419035953029791 no 1411 0.436805856946103 2095 4444231 YPR107C YTH1 SGTC_945 3381-0768 11.3 µM 0.158241668143904 0.419354227802093 no 1412 0.437133185466818 2123 1126236 YIL048W NEO1 SGTC_2796 7949634 45.45 µM 0.157454075362329 0.419655968740809 no 1413 0.43744349945436 2037 2971588 SGTC_2424 5537928 59.2 µM 0.157418335444345 0.41966966246716 no 1414 0.437457582006613 1995 5382802 SGTC_1415 3966-0071 78.1 µM 0.157383848300558 0.419682876286111 no 1415 0.437471171005033 2114 2893185 SGTC_3001 9076041 71.4286 µM 0.156106517650592 0.420172351779986 no 1416 0.437974530503728 2062 16004211 SGTC_1612 st002233 45.4 µM 0.155122783574724 0.420549404734502 no 1417 0.438362260449072 2133 1035021 SGTC_1794 st048918 76.9 µM 0.154814935983852 0.420667413856027 no 1418 0.438483607983591 2138 672303 SGTC_1174 0739-0097 51.1 µM 0.153639321200192 0.421118135057874 no 1419 0.438947065590046 2034 728447 SGTC_3261 9137475 49.47 µM 0.153010655270271 0.421359202961015 no 1420 0.439194936274697 2152 17027690 SGTC_2362 9071156 126 µM 0.152397757024446 0.421594252978815 no 1421 0.439436613025462 2104 653133 SGTC_2973 9094665 17.96 µM 0.150938047534934 0.422154172361139 no 1422 0.440012293352517 2122 25237061 YIL048W NEO1 SGTC_443 clozapine 122 µM 0.150609928889934 0.422280054717152 no 1423 0.440141714310302 2165 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1333 1482-0047 286 µM 0.149343745939139 0.422765898730133 no 1424 0.44064119901619 2163 3811116 SGTC_2265 7929201 200 µM 0.149296456600918 0.422784046289087 no 1425 0.440659855580966 2149 1265108 SGTC_2654 protoveratrine a 100 µM 0.149155912388328 0.422837981916289 no 1426 0.440715303786896 2119 5702278 A heart drug and vasodilator. SGTC_2698 st077697 67.5 µM 0.14819569612157 0.423206515757285 no 1427 0.441094164156325 1995 3154499 SGTC_2025 5147754 141 µM 0.147887476027798 0.423324825803329 no 1428 0.441215786101722 2133 315777 YLR208W SEC13 SGTC_66 0109-0187 42.4 µM 0.147060761757506 0.423642193554474 no 1429 0.441542030329201 2152 759417 SGTC_124 0136-0217 7.121 µM 0.146117152069668 0.424004496876679 no 1430 0.441914453172291 2193 3976905 SGTC_1379 2144-0755 36.5 µM 0.145451498488755 0.424260116322035 no 1431 0.442177203511411 2155 5392327 SGTC_1075 aripiprazole 15.2 µM 0.144256520460361 0.424719082967008 no 1432 0.44264895537963 2042 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1373 2887-0003 58.5 µM 0.143145425491684 0.425145923440673 no 1433 0.443087664982779 2056 776948 SGTC_809 3998-0021 90 µM 0.139089638619693 0.426704743898628 no 1434 0.444689657911622 2176 715485 SGTC_2747 doxorubicin 7.63 µM 0.138179642486747 0.427054654355199 no 1435 0.445049221845036 2183 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_667 1498-1044 59 µM 0.137176280106587 0.427440532402889 no 1436 0.445445729693052 2072 6739982 SGTC_2275 7947463 200 µM 0.136994288425589 0.427510531109291 no 1437 0.445517654861763 2172 1225414 SGTC_1742 st038235 28.8875 µM 0.13669666569726 0.427625009422861 no 1438 0.445635282590117 2040 564103 YBR002C RER2 SGTC_1707 st032323 6.317 µM 0.136199989715643 0.427816065617637 no 1439 0.445831591649058 2091 3132057 YMR211W DML1 SGTC_2572 astragaloside iv 100 µM 0.135935633104783 0.427917762497412 no 1440 0.445936082887961 2038 45006101 An anti-inflammatory agent. SGTC_1935 st074532 41.6 µM 0.135486844427081 0.428090420581376 no 1441 0.446113482487831 2168 2829742 SGTC_2636 apigenin dimethyl ether 100 µM 0.135383566713288 0.428130155557292 no 1442 0.44615430818555 2078 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.134586924535705 0.428436679422378 no 1443 0.446469240124582 2056 4330530 SGTC_746 1095-0025 46.6 µM 0.134226131123211 0.428575516054622 no 1444 0.446611881616678 2151 6749286 SGTC_1689 st020265 53.493 µM 0.134010134202543 0.428658637892785 no 1445 0.446697280393653 2164 5758320 YPR016C TIF6 SGTC_2055 5235184 200 µM 0.133765774799759 0.428752678246251 no 1446 0.446793895834922 2093 2836034 SGTC_1399 3562-5772 25 µM 0.133571472148686 0.428827457425212 no 1447 0.446870721964818 2113 23847490 SGTC_2456 5770359 74.46 µM 0.131503250554794 0.42962358951776 no 1448 0.447688607667629 2148 3118787 SGTC_1663 st014140 55.4 µM 0.131436069388527 0.429649454757612 no 1449 0.447715178451867 2190 4207120 SGTC_2018 5133068 143 µM 0.13008575581252 0.430169399237161 no 1450 0.44824928978539 2122 785362 SGTC_923 1900-2434 73.3 µM 0.129800904546214 0.430279098032256 no 1451 0.44836197362304 2169 5910570 SGTC_1999 st074831 12.5 µM 0.129766526503386 0.430292337691102 no 1452 0.448375573457642 2042 17112523 SGTC_2384 9036245 200 µM 0.126709939917237 0.43146980069577 no 1453 0.449584989169599 2141 6462766 SGTC_1630 st005209 31.3 µM 0.124663235270052 0.432258576623451 no 1454 0.450395082144913 2214 3367314 SGTC_1930 st074634 34.3 µM 0.121166321666425 0.43360686932242 no 1455 0.451779649477397 2183 684253 YOR116C RPO31 SGTC_2823 7987624 58.44 µM 0.121150713790892 0.433612888940546 no 1456 0.451785830584524 2109 2239440 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.120558279082929 0.433841389495032 no 1457 0.452020458100241 2145 5377381 SGTC_2108 5365811 200 µM 0.118020564846288 0.434820428683576 no 1458 0.453025681684051 2151 780283 SGTC_3278 9139605 49.47 µM 0.117317338581005 0.435091801338026 no 1459 0.453304292853569 2155 7958859 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.117115611205316 0.435169652904103 no 1460 0.453384219458457 2217 4000243 SGTC_59 0330-0160 1.33 µM 0.116382781739123 0.435452490982492 no 1461 0.453674590419126 2134 4293482 SGTC_1755 st041960 45.185 µM 0.115575740799569 0.435764009440901 no 1462 0.453994395037913 2116 2257073 SGTC_360 0957-0399 1.01 µM 0.115563948969488 0.43576856139282 no 1463 0.453999067986203 2183 6752301 YPR165W RHO1 SGTC_626 0214-0009 33 µM 0.114601631800721 0.436140069381459 no 1464 0.454380443121573 2162 3437874 SGTC_1927 st060202 13.8 µM 0.113719943401399 0.436480499650624 no 1465 0.454729901266308 2216 688887 SGTC_3151 9099821 49.47 µM 0.113359044181728 0.436619860673855 no 1466 0.454872954182139 2115 17174189 SGTC_888 0916-0002 6.97 µM 0.1119224074173 0.437174694943557 no 1467 0.455442464839313 2187 2802138 YIL048W NEO1 SGTC_855 0428-0020 25 µM 0.111500227364206 0.43733776593742 no 1468 0.455609842657158 2078 6812414 SGTC_1361 1608-0041 5.61 µM 0.110985927248454 0.437536433547585 no 1469 0.455813753106292 2146 X1361 SGTC_425 3825-7017 13.1 µM 0.109296331952813 0.43818921336745 no 1470 0.456483727922736 2149 3397440 SGTC_3238 9133470 49.47 µM 0.109109908912006 0.438261248761783 no 1471 0.456557657819909 2213 3534688 SGTC_3269 9137823 49.47 µM 0.108778631052641 0.438389262293852 no 1472 0.456689036588272 2060 17682936 SGTC_3225 9130819 49.47 µM 0.108459993032348 0.438512397578205 no 1473 0.456815407093656 2202 4547121 SGTC_29 0299-0004 12.984 µM 0.108437503643056 0.438521088659835 no 1474 0.456824326456484 2189 16871 A napthoquinone isolated from Swertia calycina. SGTC_3021 9087658 49.47 µM 0.108367299836057 0.43854821929012 no 1475 0.456852169647996 2221 25237042 SGTC_1299 1079-1439 3.74 µM 0.107941077279742 0.43871294143186 no 1476 0.45702121625155 2131 323161 SGTC_2989 9073649 71.4286 µM 0.105003031647297 0.439848694618308 no 1477 0.458186701556964 2242 21367202 SGTC_1092 toremifene 6.32 µM 0.1043261104803 0.440110440924973 no 1478 0.458455278901274 2230 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1884 5633444 25 µM 0.103212952225426 0.440540924661977 no 1479 0.458896980212302 2150 5724239 SGTC_1034 k072-0165 12.7 µM 0.102681579631089 0.440746443402034 no 1480 0.45910784684156 2213 5835461 SGTC_1984 st072354 53.1 µM 0.102438584376969 0.440840431889189 no 1481 0.45920427941969 2126 5762938 SGTC_2965 9082772 38.63 µM 0.102346743727602 0.440875955935392 no 1482 0.459240726973333 2235 16459634 SGTC_1898 st060199 18.6 µM 0.101764779854813 0.441101071135185 no 1483 0.459471691038214 2205 688866 SGTC_3101 9120531 49.47 µM 0.100776772457159 0.441483295590524 no 1484 0.459863832923559 2229 24824904 SGTC_3200 9114385 49.47 µM 0.10074183542264 0.44149681246989 no 1485 0.459877700211425 2110 17018030 YLR208W SEC13 SGTC_2366 9070441 60.58 µM 0.100296457658373 0.441669131786991 no 1486 0.460054484846318 2200 6837235 SGTC_3160 9100216 49.47 µM 0.100059752334219 0.441760718986007 no 1487 0.460148443952562 2246 17191039 SGTC_428 3448-4153 16.5 µM 0.0984770293130793 0.442373193816533 no 1488 0.460776755620861 2123 3834874 SGTC_2266 7929956 200 µM 0.0973338225419677 0.442815672461506 no 1489 0.461230648502281 2247 2967153 SGTC_3098 9119039 49.47 µM 0.0971689636286576 0.442879487068864 no 1490 0.46129610741023 2259 17161528 SGTC_2789 5281112 71.43 µM 0.0967690900635746 0.443034278753443 no 1491 0.461454885628358 2131 765948 SGTC_3132 9126706 49.47 µM 0.0965822287928768 0.44310661602685 no 1492 0.461529084938095 2160 850858 SGTC_1855 st056195 39.6 µM 0.0954654186259553 0.443538992272055 no 1493 0.461972578357394 2252 4028379 SGTC_3288 9119690 36.221 µM 0.0952394525071112 0.443626483894026 no 1494 0.46206231691188 2139 17595618 YKL019W RAM2 SGTC_2254 7938975 95.19 µM 0.0948338583509119 0.44378353242735 no 1495 0.462223396490731 2226 2969277 SGTC_1712 st032288 53.4 µM 0.0937807341137664 0.444191349725368 no 1496 0.462641668088562 2213 2883011 SGTC_3266 9136860 49.47 µM 0.0933480640969828 0.444358916261464 no 1497 0.462813524560365 2238 4871271 YPR165W RHO1 SGTC_370 0180-0345 38.7 µM 0.0931231785110195 0.444446014968602 no 1498 0.462902851828024 2169 3989527 SGTC_1774 st048371 48.465 µM 0.0930480521834946 0.444475112166874 no 1499 0.462932693328683 2203 4242727 SGTC_787 4152-0075 138 µM 0.092425657436598 0.444716183539201 no 1500 0.463179927493056 2103 9566539 SGTC_274 sirtinol 40.1 µM 0.0910272510686415 0.445257900973024 no 1501 0.463735468859543 2077 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2068 5226020 147 µM 0.088810092093967 0.446116997567575 no 1502 0.464616418527779 2194 1810509 SGTC_3265 9137266 49.47 µM 0.0883050049448883 0.446312742405086 no 1503 0.46481713056363 2279 17224265 SGTC_3262 9137218 49.47 µM 0.0875060553201181 0.446622399361409 no 1504 0.465134636223718 2260 17650664 SGTC_3349 9149703 23.001 µM 0.0873618829031753 0.446678281190052 no 1505 0.465191933268028 2252 4910494 SGTC_2033 5192550 145 µM 0.0864846572730846 0.447018320275614 no 1506 0.465540576046883 2195 182073 SGTC_1253 0550-0034 176 µM 0.086399283786706 0.447051415695262 no 1507 0.465574508129204 2183 5969915 SGTC_2257 7960413 200 µM 0.0854294799329268 0.44742739039187 no 1508 0.465959978613693 2189 2974689 YIL048W NEO1 SGTC_786 4544-0069 423 µM 0.0849050401078627 0.44763072554303 no 1509 0.466168442416263 2179 748821 YLR208W SEC13 SGTC_1472 k841-0093 193 µM 0.0838758346699903 0.448029807744393 no 1510 0.466577576491238 2234 X1472 SGTC_3009 9080819 71.4286 µM 0.0805895289486572 0.449304447893697 no 1511 0.467884196903447 2176 17027216 SGTC_1840 st055363 71 µM 0.0797682256077891 0.449623084260676 no 1512 0.468210798030438 2106 676033 SGTC_953 1188-0045 9.7 µM 0.0797480357294307 0.449630917622422 no 1513 0.468218827048161 2197 6144426 SGTC_2008 4012253 172 µM 0.0784310760448165 0.450141919947528 no 1514 0.468742577275764 2236 603940 SGTC_1781 st038725 66.3 µM 0.0782851057177427 0.450198563974248 no 1515 0.468800632507721 2099 4270275 YIL048W NEO1 SGTC_2283 7944793 200 µM 0.0781422544667741 0.450253998620599 no 1516 0.468857447864893 2220 2970533 SGTC_866 0495-0101 262 µM 0.0770494235265678 0.450678113023425 no 1517 0.469292113752462 2075 635694 SGTC_261 5-fluorouridine 15.376 µM 0.0764880449340686 0.450895999158762 no 1518 0.46951541243644 2257 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1427 4048-4900 550 nM 0.0764532085940239 0.450909520567882 no 1519 0.469529269549574 2268 24132586 SGTC_2014 4013930 200 µM 0.0762877224811051 0.450973753278027 no 1520 0.469595096709835 2298 64556 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0742086336364396 0.451780851352761 no 1521 0.47042218807341 2288 1241132 A phosphatase inhibitor. SGTC_528 3492-0019 172 µM 0.0705250846815465 0.453211284965762 no 1522 0.471887867783234 2282 2869262 SGTC_1208 2323-2347 50.3 µM 0.0685637233289744 0.453973189942855 no 1523 0.472668447737085 2290 5412760 SGTC_2179 6298986 200 µM 0.0679940672202695 0.454194508842423 no 1524 0.472895178514323 2289 738374 SGTC_1680 diphenhydramine 100 µM 0.0675111640126203 0.454382134239266 no 1525 0.473087387353315 2131 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_391 gliotoxin 8.33 µM 0.0668182252192128 0.454651383845946 no 1526 0.473363207103372 2244 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2757 clomiphene 4.22 µM 0.0665621497018768 0.454750890312358 no 1527 0.473465139525351 2298 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1515 3460-0031 42.1 µM 0.0658104951201586 0.455042986510679 no 1528 0.473764350227395 2251 2876596 SGTC_757 1066-0008 322 µM 0.0655036225541243 0.455162245504497 no 1529 0.47388651107572 2269 6842497 SGTC_1119 parthenolide 318.541 nM 0.0653114796299554 0.455236919508823 no 1530 0.473963001218746 2231 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2391 6285546 200 µM 0.0647886848477284 0.455440105324175 no 1531 0.47417112535282 2290 846083 SGTC_142 0335-0849 62.6745 µM 0.0643749028327897 0.455600931255534 no 1532 0.474335856602611 2279 3889043 YPR107C YTH1 SGTC_2966 9084041 48.03 µM 0.0609569497082334 0.456929673488491 no 1533 0.475696747209041 2284 17741380 SGTC_1025 k007-0731 70 µM 0.0588756567386155 0.457739020932484 no 1534 0.47652557375869 2275 6256118 SGTC_1550 gossypolone 36.6 µM 0.0588275606287303 0.457757726037211 no 1535 0.476544728131008 2297 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2303 7774051 200 µM 0.0587281803555939 0.457796376411945 no 1536 0.476584306695933 2283 2953184 SGTC_1362 1611-0397 101 µM 0.0566623985990831 0.458599877588907 no 1537 0.477407063719677 2293 27816 SGTC_879 0831-1030 162 µM 0.055811031423358 0.458931072601701 no 1538 0.477746173419044 2306 1549252 SGTC_1037 k284-1091 78.7 µM 0.0557433208949707 0.458957414272422 no 1539 0.477773144024957 2298 3334711 SGTC_2706 st078239 82.5 µM 0.0538853770076895 0.459680286794292 no 1540 0.47851324359798 2323 15434492 SGTC_2313 7726885 200 µM 0.0529572639081714 0.460041438982256 no 1541 0.4788829791819 2272 726423 SGTC_1951 sophoraflavanone G 9.2 µM 0.0519381613747331 0.460438035417299 no 1542 0.479288983458136 2312 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_81 0411-0046 9.971 µM 0.0501262447052314 0.461143262290831 no 1543 0.480010892886032 2312 12925265 SGTC_814 3342-0569 96 µM 0.0482985953984293 0.461854736365465 no 1544 0.480739136979428 2328 4346283 SGTC_3301 9125354 19.7965 µM 0.0472604281781206 0.462258932452853 no 1545 0.48115283327971 2306 41905162 SGTC_2683 piperine 63.03 µM 0.0470841729062878 0.462327558893678 no 1546 0.481223070769066 2294 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1419 3993-2473 62.6 µM 0.0462691355946159 0.462644914930591 no 1547 0.4815478695898 2303 704026 SGTC_1653 st012112 65 µM 0.0451524877727401 0.463079749453946 no 1548 0.481992882429885 2315 720429 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0441074641150052 0.463486732741663 no 1549 0.482409371536688 2317 688798 SGTC_2348 9022543 33.42 µM 0.0434992370567876 0.463723623706889 no 1550 0.482651786346258 2282 3162678 YDL140C RPO21 SGTC_2688 kanamycin b 96.69 µM 0.0434044297786164 0.463760550202333 no 1551 0.482689573289111 2282 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_154 3389-1638 511.116 µM 0.0411054277128632 0.464656083553198 no 1552 0.483605923786693 2121 5238686 SGTC_102 gallobenzophenone 83.616 µM 0.0407411795452828 0.464797986178768 no 1553 0.483751116151536 2337 70837 SGTC_1215 3852-0577 11.2 µM 0.0379733881488396 0.465876398392097 no 1554 0.484854449950297 2329 2884876 SGTC_609 0986-0026 86.3 µM 0.0373930198254166 0.466102558859328 no 1555 0.485085819076299 2330 2848610 SGTC_1368 1852-0141 284 µM 0.0368834946120738 0.466301121900141 no 1556 0.48528895009208 2301 2838987 SGTC_3018 9082602 49.47 µM 0.0365981383601961 0.466412329495648 no 1557 0.485402713955413 2308 17332089 SGTC_2174 5790901 200 µM 0.0362198828502449 0.466559745360742 no 1558 0.485553516084236 2302 786020 SGTC_599 1935-0052 86.5 µM 0.0359088893827048 0.466680950921706 no 1559 0.48567750386891 2336 9557311 SGTC_2998 9066762 71.4286 µM 0.0313531086096447 0.468456854130477 no 1560 0.487493968328319 2326 4945196 SGTC_3228 9131799 49.47 µM 0.0293901396382767 0.469222240847465 no 1561 0.488276718418977 2292 17015818 SGTC_2808 7946468 45.46 µM 0.029204560403412 0.469294606495077 no 1562 0.488350722055261 2331 2970879 SGTC_2871 9038510 12.99 µM 0.0280233836676823 0.469755223831458 no 1563 0.488821750499442 2368 4945164 SGTC_2813 7971799 71.43 µM 0.0279260081098662 0.469793198684714 no 1564 0.488860582528889 2321 2234054 SGTC_981 1488-1094 54.9 µM 0.0269025025672757 0.470192365433865 no 1565 0.489268748740521 2353 3449522 SGTC_306 1672-3436 11.6 µM 0.0256414773603266 0.470684205902606 no 1566 0.489771651392869 2342 6797378 SGTC_207 4185-0010 4.486 µM 0.0252176682869501 0.470849515177322 no 1567 0.489940672091226 2364 3761753 SGTC_3155 9099265 49.47 µM 0.0236949722581199 0.47144349315289 no 1568 0.490547958219076 2354 25236499 SGTC_643 k048-0106 28.4 µM 0.0199407848549049 0.472908206826236 no 1569 0.492045304997876 2363 6763920 SGTC_1130 3454-2858 15.9 µM 0.0174367644877623 0.473885366937871 no 1570 0.493044089894243 2309 715628 YIL048W NEO1 SGTC_2408 sulbentine 18.36 µM 0.0169102993788837 0.474090833022189 no 1571 0.493254088113214 2287 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3094 9117742 49.47 µM 0.0164471817000211 0.474271581898456 no 1572 0.493438819638333 2380 17149698 SGTC_1907 st060210 83.7 µM 0.0160444017000381 0.474428786061765 no 1573 0.493599484405757 2368 688793 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0141080589575514 0.475184591597443 no 1574 0.494371885488868 2378 616764 SGTC_995 3931-2021 34.6 µM 0.0129070092289648 0.475653437967572 no 1575 0.49485099126842 2360 730143 SGTC_1750 st081859 2.357 µM 0.0126369341205057 0.475758870186615 no 1576 0.494958726860292 2384 5291695 SGTC_2959 9079155 11 µM 0.0121014757020548 0.475967908046523 no 1577 0.495172327519478 2367 16189457 SGTC_1646 st011709 75.6 µM 0.0114634479689348 0.476216996620098 no 1578 0.495426846086409 2379 5757843 SGTC_1207 2099-0101 141 µM 0.0112102713001453 0.476315840383193 no 1579 0.495527842473273 2385 5837381 SGTC_2323 6148992 148.28 µM 0.0103847108482257 0.476638160987358 no 1580 0.495857174234954 2376 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2913 7966556 36.57 µM 0.0101857818236045 0.476715830425775 no 1581 0.495936531235991 2385 2976516 SGTC_956 1185-0240 191 µM 0.00777393000468149 0.477657578387516 no 1582 0.496898681873786 2379 1416193 SGTC_1942 st076330 65.2 µM 0.00624225313135418 0.478255712406761 no 1583 0.497509717473555 2386 24208414 SGTC_1912 st060209 90.8 µM 0.0056701780862676 0.478479125650866 no 1584 0.497737938345216 2389 688787 SGTC_1020 4335-0961 93.3 µM 0.00534419508356267 0.478606435264683 no 1585 0.497867984775 2387 669075 SGTC_1597 7-benzyloxygramine 47.5 µM 0.00380193117796013 0.479208781388174 no 1586 0.498483252559953 2398 260807 SGTC_1312 1218-2183 165 µM 0.00309957323451694 0.4794831099135 no 1587 0.498763451165545 2400 6744073 SGTC_2071 5230951 39.92 µM 0.00303992677052054 0.479506407211416 no 1588 0.498787246549789 2401 1799272 SGTC_195 4234-0266 16.654 µM 0.00296293693876176 0.479536478754639 no 1589 0.498817960910484 2400 2303354 SGTC_429 1112-0049 25.5 µM 0.00236836275608865 0.479768718050054 no 1590 0.499055160844558 2399 2836170 SGTC_2962 9082311 13.18 µM 0.00158854189805559 0.480073324665525 no 1591 0.499366263739212 2396 16459453 SGTC_228 caffeine 993.056 µM 0.0015519742394542 0.480087608682718 no 1592 0.499380852106337 2400 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2845 9003024 42.97 µM 0.000454484471963117 0.480516320704232 no 1593 0.49981868693459 2405 2990173 SGTC_155 k072-0202 43.6 µM 0.000118868189105941 0.480647426891144 no 1594 0.499952578453683 2404 5857737 SGTC_93 0109-0045 59.227 µM 5.40192075089606e-05 0.480672759940454 no 1595 0.499978449454181 2401 88733 SGTC_529 4076-0302 30.3 µM -0.000149863416408478 0.480752406549871 no 1596 0.499940213147133 2405 5816522 SGTC_966 1300-0360 30.2 µM -0.00369910932959643 0.482139037402112 no 1597 0.498524272254095 2411 70588 SGTC_3045 9092950 49.47 µM -0.00417073883491371 0.482323311770238 no 1598 0.498336120762123 2412 44120432 SGTC_1401 3807-4679 7.6 µM -0.00461725550411837 0.482497777569816 no 1599 0.498157988104983 2411 3291456 SGTC_1716 st033144 30.6155 µM -0.00528300675558298 0.482757910297324 no 1600 0.497892395041488 2416 674617 SGTC_1225 1216-0074 20.6 µM -0.00530652675500837 0.482767100533756 no 1601 0.497883012050807 2430 4241466 SGTC_2325 6158266 200 µM -0.00710216347062446 0.483468756728844 no 1602 0.497166670528465 2432 3623240 SGTC_1862 st057513 3.81 µM -0.00767815391882268 0.483693839522418 no 1603 0.496936889863505 2419 5393163 SGTC_1962 st076595 64.5 µM -0.00770840359940557 0.48370566049222 no 1604 0.496924822344075 2420 279619 SGTC_616 4092-0450 108 µM -0.00806781630375728 0.483846112877491 no 1605 0.496781441881766 2422 787165 SGTC_2150 5556613 200 µM -0.00832354181955317 0.483946047290636 no 1606 0.496679425587847 2425 743190 SGTC_2364 9055074 200 µM -0.00956553228213733 0.484431416246217 no 1607 0.496183962932388 2430 6470630 SGTC_979 1426-2828 121 µM -0.00976346207637658 0.484508769213405 no 1608 0.496105004056608 2447 747872 SGTC_2941 9056145 11.23 µM -0.0113616042160615 0.485133360445307 no 1609 0.495467473219566 2422 2119517 SGTC_708 3448-5400 146 µM -0.0119975341271767 0.48538190692104 no 1610 0.495213791198193 2421 3462195 SGTC_596 1155-0152 116 µM -0.0124658191491035 0.485564934802215 no 1611 0.49502698648019 2431 280313 SGTC_1109 tnp00067 928.257 nM -0.0125125242557891 0.485583189528955 no 1612 0.495008355291521 2432 676295 SGTC_949 1165-0505 146 µM -0.0126874909312342 0.485651575656416 no 1613 0.494938559227752 2433 6244267 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0131286697948845 0.485824013298814 no 1614 0.494762568989479 2439 1273210 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0131784094048767 0.485843454517348 no 1615 0.494742727472564 2430 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3355 9151058 44.0485 µM -0.0138736696408797 0.48611520735865 no 1616 0.494465384145787 2427 17015728 SGTC_2785 7756463 72.73 µM -0.0145849606158309 0.486393232725334 no 1617 0.494181648834074 2438 2201551 SGTC_541 4513-1321 94 µM -0.0146831224126083 0.486431602171989 no 1618 0.494142492136064 2447 747515 SGTC_1127 asiatic acid 681.4 nM -0.0167354992381191 0.487233862691297 no 1619 0.493323813412722 2446 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1223 0764-0573 147 µM -0.0169235219140427 0.487307362143554 no 1620 0.49324881383964 2453 1609797 SGTC_1815 st051655 58.2 µM -0.0174230471431539 0.487502632331233 no 1621 0.493049561491779 2428 5984156 SGTC_1049 3226-0134 66 µM -0.018307377158642 0.487848334476836 no 1622 0.492696821166082 2426 5702385 SGTC_2526 patulin 37.61 µM -0.0184182594753792 0.48789168122357 no 1623 0.492652592979157 2463 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2972 9093619 59.92 µM -0.0186665551138438 0.487988746886601 no 1624 0.492553554378421 2445 25236256 SGTC_2740 felodipine 17.08 µM -0.0191627347608031 0.488182719420846 no 1625 0.492355642746579 2446 3333 L-type calcium channel blocker SGTC_1666 st014829 29 µM -0.0193084396429761 0.488239680664398 no 1626 0.492297525661553 2435 3858230 SGTC_464 bw-b 70c 158 µM -0.0193455669565025 0.488254195095976 no 1627 0.492282716772494 2484 5353454 SGTC_1319 1306-0155 43.7 µM -0.0199979877105946 0.488509252871594 no 1628 0.492022488909897 2446 3122360 SGTC_3260 9137109 49.47 µM -0.0205809698493777 0.488737168250727 no 1629 0.49178996055589 2432 17478346 SGTC_845 0330-0138 4.51 µM -0.0207526973589847 0.4888043053869 no 1630 0.491721465820913 2427 9039800 SGTC_1239 0337-0584 35.4 µM -0.0208940919874825 0.488859584074387 no 1631 0.491665069753812 2453 914301 YML130C ERO1 SGTC_2091 4-phenylthiadiazole 200 µM -0.0213919929460775 0.489054241761604 no 1632 0.491466480404512 2452 270010 SGTC_1583 clindamycin 39.6 µM -0.0221418430021986 0.489347405527552 no 1633 0.49116740437948 2455 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_407 eburnamonine 100 µM -0.0222407107400545 0.489386059606069 no 1634 0.491127971569292 2446 3195 SGTC_439 amiodarone 34.4 µM -0.0227679892339325 0.489592210068492 no 1635 0.490917671146596 2495 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_487 nimodipine 119 µM -0.0234500972929763 0.489858898477382 no 1636 0.490645622057911 2450 4497 L-type voltage-gated calcium channels inhibitor SGTC_1310 1188-0297 994 nM -0.0239856292391212 0.490068282213527 no 1637 0.490432035808177 2460 1588352 SGTC_1987 st072290 61.9 µM -0.0247452724232595 0.490365294251699 no 1638 0.490129071975693 2489 54697379 SGTC_1909 st060837 51.5 µM -0.0248524062033762 0.490407182802108 no 1639 0.49008634492138 2469 678937 SGTC_1232 0279-0259 161 µM -0.0253402217649051 0.490597916567705 no 1640 0.489891795946326 2459 1560000 SGTC_3097 9117246 49.47 µM -0.025454852298222 0.490642736921879 no 1641 0.489846079726642 2447 16423892 SGTC_2978 9011784 42.97 µM -0.026119495967137 0.490902613838249 no 1642 0.48958101341692 2482 2994934 SGTC_460 trequinsin 123 µM -0.0269127624867528 0.491212787575367 no 1643 0.48926465710633 2448 5537 A vasodilator. SGTC_2748 diazoxide 86.69 µM -0.0272485404033278 0.491344081115394 no 1644 0.489130750209309 2478 3019 A potassium channel activatior. SGTC_869 0564-0080 44.1 µM -0.027373606008541 0.4913929836369 no 1645 0.489080874855949 2497 6843321 SGTC_271 rotenone 740 µM -0.0275289603976403 0.491453729705834 no 1646 0.489018920769613 2525 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1144 3486-0183 12.5 µM -0.0285595759872792 0.491856721956904 no 1647 0.488607926305694 2477 6744069 SGTC_106 0092-0003 11.579 µM -0.0297847838011721 0.492335814618098 no 1648 0.488119347075627 2508 1072148 SGTC_3339 9145883 14.936 µM -0.0301416196632854 0.492475350152867 no 1649 0.487977054053032 2479 2030670 SGTC_1434 4073-0095 163 µM -0.0302543877306069 0.492519446676956 no 1650 0.487932086611139 2459 24133745 SGTC_2506 ethyl hematommate 54.16 µM -0.0308630032545672 0.492757439631626 no 1651 0.487689397491985 2506 3940691 An allergen. SGTC_2290 7904846 200 µM -0.0308778727207911 0.492763254218844 no 1652 0.487683468259127 2483 2962154 SGTC_1814 st052110 31.539 µM -0.0315902033988018 0.493041807277869 no 1653 0.487399428023715 2467 674163 SGTC_2822 7994718 71.43 µM -0.0328067081193091 0.493517522640476 no 1654 0.486914364394041 2457 1018011 SGTC_637 1181-0519 7.26 µM -0.0328531987183883 0.493535703021987 no 1655 0.486895827320803 2466 6252091 YGR060W ERG25 SGTC_3186 9110464 49.47 µM -0.0341021854905315 0.494024130455931 no 1656 0.486397832865394 2492 17018021 SGTC_230 MPP+ 141.667 µM -0.0344047918180103 0.494142468739411 no 1657 0.486277181208656 2489 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2540 epiandrosterone 100 µM -0.0355567183729821 0.494592949773505 no 1658 0.485817910107597 2477 441302 A steroid. SGTC_1797 st048695 56.8 µM -0.0372019632053011 0.49523636336617 no 1659 0.485161986643009 2457 592262 YIL048W NEO1 SGTC_2111 5486399 200 µM -0.0375775640431073 0.49538325314062 no 1660 0.485012248292412 2464 689674 SGTC_3050 9093513 49.47 µM -0.0378844230797562 0.495503259873792 no 1661 0.484889916357624 2480 25236664 SGTC_1874 staurosporine 7.6 µM -0.0379707442349449 0.495537018509676 no 1662 0.484855503959185 2496 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3201 9113999 49.47 µM -0.0396306622108653 0.496186188210505 no 1663 0.48419379086276 2547 16649224 SGTC_2343 7990716 14.84 µM -0.0408396047522653 0.496658994453215 no 1664 0.483711882827912 2486 6456862 SGTC_1650 st011916 45.8 µM -0.0422272259372416 0.497201686004596 no 1665 0.483158779376702 2490 242528 SGTC_472 calcifediol 10 µM -0.0423729446493878 0.497258676165785 no 1666 0.4831006980071 2535 5283731 A vitamin D metabolite. SGTC_292 k038-0015 474 µM -0.0439571685164902 0.497878264839845 no 1667 0.482469272707742 2528 46368540 SGTC_218 alverine citrate 93.75 µM -0.0444168210249798 0.498058035588492 no 1668 0.482286076820865 2545 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3089 9117425 49.47 µM -0.04467981425947 0.498160892795575 no 1669 0.482181261757591 2535 9401657 SGTC_1070 indatraline 8.81 µM -0.0447283775287456 0.498179886005892 no 1670 0.482161907165522 2502 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2220 6782180 200 µM -0.0451871158292518 0.498359299845746 no 1671 0.481979081919905 2495 833803 SGTC_861 0443-0273 110 µM -0.0464322124171296 0.49884626219209 no 1672 0.481482881197968 2560 6149169 SGTC_3303 9125618 40.5795 µM -0.0464670769907326 0.498859897896942 no 1673 0.481468987242146 2535 22695467 SGTC_2951 9072950 58.06 µM -0.0470391189398622 0.499083626472953 no 1674 0.481241024807869 2486 16488155 SGTC_45 0kpi-0036 14.9 µM -0.0471345401757649 0.499120946243634 no 1675 0.481202999420173 2520 2795021 SGTC_1770 st043884 66.3 µM -0.047736486427667 0.499356370900635 no 1676 0.480963127636345 2493 670149 SGTC_2020 4017018 200 µM -0.0484941856997167 0.499652711772301 no 1677 0.480661199065703 2537 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2448 5185112 27.17 µM -0.0489032943814771 0.499812716798163 no 1678 0.480498181734343 2549 5718189 SGTC_1736 st036774 51 µM -0.0498610039097983 0.499812716798163 no 1679 0.480116576500121 2495 1272247 SGTC_1404 3909-7820 48.3 µM -0.0506466764169971 0.499505435296975 no 1680 0.479803534062435 2497 23741373 SGTC_3004 9076122 71.4286 µM -0.05070975956761 0.499480763086927 no 1681 0.479778399823116 2515 44782551 SGTC_577 r071-0003 38.6 µM -0.0516319101666998 0.49912010456448 no 1682 0.479410996302929 2508 4568517 YMR134W ERG29 SGTC_1388 3346-4487 254 µM -0.0522037889597022 0.498896439747855 no 1683 0.479183156949536 2544 3345614 SGTC_2878 9043973 25.97 µM -0.0540659616040696 0.498168136960703 no 1684 0.478441305634809 2644 6465167 SGTC_648 0375-0473 33.3 µM -0.0540769198759583 0.498163851154676 no 1685 0.478436940303004 2509 1713139 SGTC_982 1491-0518 27.5 µM -0.0546482477570499 0.497940403775677 no 1686 0.478209350004668 2541 3091256 SGTC_2146 5545642 200 µM -0.0546529060638061 0.497938581905947 no 1687 0.478207494382298 2500 825326 SGTC_454 lyso-paf C-16 6.67 µM -0.0564877833227732 0.497220962793912 no 1688 0.4774766137412 2533 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2620 irigenin 100 µM -0.0570556556484373 0.496998870069521 no 1689 0.47725043025538 2562 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3142 9086498 49.47 µM -0.0579965113944808 0.496630907016739 no 1690 0.476875703677584 2506 25236367 SGTC_3158 9100007 49.47 µM -0.0587031189782044 0.496354558886239 no 1691 0.47659428751956 2525 19297233 SGTC_3165 9101544 49.47 µM -0.0594295603821098 0.496070455744695 no 1692 0.476304984441075 2547 5002184 SGTC_985 1493-0307 8.71 µM -0.0600491341548851 0.495828148912499 no 1693 0.476058250934257 2528 3278274 SGTC_2555 cholic acid 100 µM -0.0607234676051697 0.495564428071218 no 1694 0.475789720859704 2649 6708657 Influences liver metabolism. SGTC_1708 st033234 31.827 µM -0.0618333885998464 0.495130360303235 no 1695 0.475347757046305 2600 674664 SGTC_2165 5727197 32.143 µM -0.0626973713670813 0.494792477991815 no 1696 0.475003745311252 2834 1361712 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0630498813862811 0.49465462109309 no 1697 0.47486339185053 2591 5282362 SGTC_168 3970-0862 530.542 µM -0.0632625852129815 0.494571438829285 no 1698 0.474778704366447 2572 3135186 SGTC_772 k072-0172 35.3 µM -0.0638577251326353 0.494338698227685 no 1699 0.474541756997998 2537 5861980 SGTC_1470 k295-0292 231 µM -0.0639505647190536 0.494302391741985 no 1700 0.474504794910571 2620 5045612 SGTC_3041 9091929 49.47 µM -0.0644705129968071 0.494099058081602 no 1701 0.474297792735729 2586 25236887 SGTC_854 0422-0053 192 µM -0.0649849623375391 0.493897876372662 no 1702 0.474092986630558 2531 3596728 SGTC_1170 0310-0127 64.8 µM -0.0654809958934853 0.493703897850794 no 1703 0.473895518469136 2581 774975 SGTC_2809 7964133 12.99 µM -0.0677601886540942 0.492812618228867 no 1704 0.472988267869941 2555 1253665 SGTC_1647 st011722 22.4 µM -0.0685354835508388 0.492509446675095 no 1705 0.472679687339808 2572 2854783 SGTC_2085 5307070 144.047 µM -0.0696569209823561 0.49207092714034 no 1706 0.472233365264 2527 2840351 SGTC_2061 5245884 80.95 µM -0.069848544357552 0.491995996937021 no 1707 0.472157104345286 2553 573863 SGTC_2459 5811157 9.22 µM -0.0703927876448933 0.491783183843113 no 1708 0.471940515817784 2520 2870684 YBR192W RIM2 SGTC_3330 9141424 71.43 µM -0.0711446120988294 0.491489205044984 no 1709 0.471641331390558 2565 27261020 SGTC_2411 st077133 39.94 µM -0.0715932535082455 0.491313779234451 no 1710 0.471462804609823 2814 1403142 YNL221C POP1 SGTC_1005 4092-0690 4.4 µM -0.0755364681542485 0.489771996677869 no 1711 0.469893941507026 2567 1529343 SGTC_1673 st016611 27.3 µM -0.075574321517051 0.489757196854648 no 1712 0.469878883242486 2715 5226799 SGTC_964 1287-0107 19.4 µM -0.0760937408191186 0.48955411688953 no 1713 0.46967225990372 2597 51516812 YPR165W RHO1 SGTC_1244 0416-0015 52.5 µM -0.0765036828063144 0.489393841727742 no 1714 0.469509192054324 2574 96201 SGTC_1540 guanosine 70.6 µM -0.0771723633205606 0.489132411160645 no 1715 0.469243213469792 2521 6802 Guanosine is a purine nucleoside SGTC_2627 acetyl isogambogic acid 100 µM -0.0781554706753995 0.488748059266101 no 1716 0.468852191436166 2618 6857789 A caspase activator and apoptosis inducer. SGTC_52 0329-0193 875 nM -0.0782194567188177 0.488723043885411 no 1717 0.46882674260501 2738 3739292 SGTC_1769 st044406 64.4 µM -0.0786762110960486 0.488544476791857 no 1718 0.468645083804434 2549 670903 SGTC_1965 Pectolinarigenin 58.4 µM -0.0787438295040572 0.488518041722036 no 1719 0.468618191394539 2564 5320438 An anti-inflammatory. SGTC_433 pimozide 108 µM -0.079354075689366 0.488279471401492 no 1720 0.468375497843377 2531 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.080106365538582 0.487985376154129 no 1721 0.468076330026381 2547 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2836 9010338 19.48 µM -0.0812467616010296 0.487539569726097 no 1722 0.467622856014043 2568 2994051 SGTC_2517 totarol 10 µM -0.0819629325548905 0.487259610342569 no 1723 0.467338094889058 2601 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_54 0159-0055 9 µM -0.0823580417564547 0.4871051603336 no 1724 0.467181000241584 2543 3319099 SGTC_87 0100-0052 35.5 µM -0.0823913079302271 0.487092156520814 no 1725 0.467167773908787 2575 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1947 st076332 61.6 µM -0.0835786436429598 0.486628033745463 no 1726 0.466695723709419 2545 24208416 SGTC_3242 9133940 49.47 µM -0.0836460602868557 0.486601681500345 no 1727 0.466668922208687 2702 17248444 SGTC_150 3970-0969 77.2 µM -0.0842596851838106 0.486361826614846 no 1728 0.466424982467305 2690 6615640 SGTC_47 0149-0135 24.25 µM -0.0850080552971938 0.486069308944931 no 1729 0.466127493346017 2527 5239155 SGTC_613 3914-0030 117 µM -0.0872905050836427 0.485177207908535 no 1730 0.465220300529206 2516 1145395 SGTC_25 0118-0223 35.662 µM -0.0890846293610212 0.484476021932352 no 1731 0.464507326407843 2580 5333628 SGTC_1198 1612-1005 86.7 µM -0.0891041370252258 0.484468398138121 no 1732 0.464499574802316 2708 6998509 SGTC_1421 4029-0249 71.4 µM -0.0895419982375132 0.484297279007532 no 1733 0.464325588922245 2640 2894095 SGTC_2655 perillic acid 100 µM -0.089962931363782 0.484132778213775 no 1734 0.464158335914378 2563 5702197 An apoptosis inducer. SGTC_2741 miltefosine 3.04 µM -0.0902769906424714 0.484010045509775 no 1735 0.464033552142712 2586 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1979 st071809 45.3 µM -0.0908806705198158 0.483774134873434 no 1736 0.463793704657634 2708 4976333 SGTC_2168 5727979 200 µM -0.0915823482965112 0.483499935012585 no 1737 0.463514938260905 2552 695210 SGTC_3322 9139058 2.11 µM -0.0916969965101951 0.483455133812831 no 1738 0.463469391888529 2709 4908926 YPR165W RHO1 SGTC_3123 9126162 49.47 µM -0.092296427991759 0.483220896773752 no 1739 0.463231263153786 2580 25239884 SGTC_1802 st050112 57.9 µM -0.0925588151032026 0.483118366805773 no 1740 0.463127032010014 2538 4662563 SGTC_2131 toluylene red 5.2905 µM -0.0933424063945615 0.482812178597995 no 1741 0.462815771845042 2597 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2463 5473429 200 µM -0.0940288953402818 0.482543941444995 no 1742 0.46254310162782 2649 5399405 SGTC_1128 3448-9350 235 µM -0.0949615238306211 0.482179540959764 no 1743 0.462172694149716 2694 619386 SGTC_686 1319-0111 510 µM -0.0962815972317022 0.481663781907515 no 1744 0.461648463229676 2631 4562600 SGTC_1133 3473-0247 50 µM -0.0964967256891204 0.481579733065671 no 1745 0.461563037156925 2663 711311 SGTC_2379 9035213 200 µM -0.096999394666017 0.481383347808952 no 1746 0.461363437585116 2567 646551 SGTC_1799 st045822 46.1415 µM -0.0976422786994597 0.481132189215407 no 1747 0.461108175670867 2581 3674992 SGTC_2646 retinol 96.75 µM -0.0992333725407189 0.480510621355951 no 1748 0.460476489081187 2653 445354 A vitamin A analog and teratogen. SGTC_2916 7875993 68.79 µM -0.100009890154119 0.480207288420887 no 1749 0.46016823680304 2582 1299250 SGTC_2744 captopril 92.04 µM -0.10093256625784 0.479846876158814 no 1750 0.459801995485428 2610 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_745 0469-0705 296 µM -0.101883877726331 0.479475295712174 no 1751 0.459424423537348 2648 3486736 SGTC_727 3032-0951 202 µM -0.101910987865593 0.479464706803305 no 1752 0.459413664159591 2652 3652836 SGTC_284 0988-0104 32.6 µM -0.102118753168991 0.479383556544944 no 1753 0.459331207976211 2661 4666532 SGTC_134 0269-0018 6.916 µM -0.10483490582118 0.478322744682253 no 1754 0.458253405904729 2674 4378915 SGTC_236 1509-0011 5.31 µM -0.105318496468328 0.47813389095873 no 1755 0.458061543268611 2652 3107280 SGTC_2483 5729050 27.16 µM -0.105652868747687 0.478003313448199 no 1756 0.457928888128576 2627 2865180 SGTC_2260 7964312 200 µM -0.106138741279585 0.47781357697446 no 1757 0.457736136819159 2797 231951 SGTC_2005 4024620 188 µM -0.106229033944978 0.477778317637454 no 1758 0.457700317757879 2616 236743 SGTC_1151 3909-8316 15.3 µM -0.106721778596241 0.477585903643788 no 1759 0.45750485222884 2696 800431 SGTC_1995 st072814 61.1 µM -0.10826767849215 0.476982272612729 no 1760 0.456891680349725 2609 5769371 SGTC_3282 9108498 15.4605 µM -0.108321021277027 0.476961444669416 no 1761 0.456870524078764 2691 16459645 SGTC_743 1275-0778 158 µM -0.10833619928118 0.476955518357218 no 1762 0.456864504355989 2695 2849257 YMR203W TOM40 SGTC_2546 rhodinyl acetate 100 µM -0.108990221163633 0.47670015776609 no 1763 0.456605123254931 2613 6708682 SGTC_1214 0358-0031 63.7 µM -0.109170607161947 0.476629728353342 no 1764 0.456533586513275 2889 4301366 SGTC_163 TUB2.036 7.546 µM -0.111704366488236 0.475640532488097 no 1765 0.455528908522567 2611 15992207 YJR013W GPI14 SGTC_1495 4469-0029 237 µM -0.112260342836615 0.475423495633711 no 1766 0.455308492409112 2598 793680 SGTC_445 e6 berbamine 66 µM -0.112546829911164 0.475311662327979 no 1767 0.455194920340583 2687 6610268 A calcium/calmodulin antagonist. SGTC_3167 9103034 49.47 µM -0.112719544072293 0.475244242439824 no 1768 0.455126453035834 2598 5127859 SGTC_3243 9134147 49.47 µM -0.112895406414621 0.475175594370798 no 1769 0.455056739099483 2609 24282180 SGTC_2560 caryophyllene 100 µM -0.1133102180634 0.475013675086021 no 1770 0.45489230828592 2595 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_357 1325-0123 420 µM -0.116160818516057 0.473901073016507 no 1771 0.453762544388761 2625 1098503 SGTC_2206 7254556 146.969 µM -0.11767703223593 0.473309370411205 no 1772 0.453161782966844 2666 4398905 SGTC_543 3844-1095 191 µM -0.117736322828042 0.47328623343764 no 1773 0.45313829273473 2712 4230703 SGTC_2883 9059145 45.46 µM -0.117930436398035 0.473210485111143 no 1774 0.453061388379284 2582 16476510 SGTC_2513 baicalein 25.65 µM -0.117933199717555 0.473209406796664 no 1775 0.453060293613777 2653 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2980 9014342 25.29 µM -0.118194829645313 0.473107313326544 no 1776 0.452956643294006 2782 2996599 SGTC_3137 9097352 49.47 µM -0.11890618751142 0.472829735558856 no 1777 0.452674839809236 2849 44120435 SGTC_14 0354-0009 295 µM -0.119122013231517 0.472745521166786 no 1778 0.452589345439952 2586 1713507 SGTC_308 4092-1169 104 µM -0.119169581911726 0.472726960208666 no 1779 0.452570502502513 2633 2268590 YDL196W YDL196W SGTC_737 1950-0117 57.9 µM -0.120748157014778 0.472111045351422 no 1780 0.451945257119883 2637 5393513 SGTC_311 1315-0136 58 µM -0.120986408206495 0.472018092306201 no 1781 0.451850900393703 2754 6759207 SGTC_3175 9106517 49.47 µM -0.123994339346849 0.470844689033281 no 1782 0.45065987851136 2707 41468073 SGTC_3130 9127414 49.47 µM -0.125018763360296 0.470445115309584 no 1783 0.450254347933459 2607 1494646 SGTC_1988 st071872 53.4 µM -0.125281392670787 0.4703426822569 no 1784 0.450150391306354 2620 16414116 SGTC_1527 coumarin 137 µM -0.125317329105376 0.470328666157003 no 1785 0.450136166844138 2853 323 A hepatotoxic, DNA x-linker. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.125773097452694 0.470150908404199 no 1786 0.449955768878944 2628 16486 A toxic proline analog. SGTC_1820 st053765 18.6 µM -0.127339611733034 0.469539985578213 no 1787 0.449335804925234 2699 3690829 SGTC_928 2764-0428 58.7 µM -0.127438413049455 0.469501456572616 no 1788 0.44929670742959 2760 662578 SGTC_811 0416-0114 265 µM -0.129029583885703 0.468880996021983 no 1789 0.448667119967335 2717 6612453 SGTC_2087 5276107 200 µM -0.1290324474488 0.46887987947295 no 1790 0.448665987041351 2636 144405 SGTC_13 0199-0087 65 µM -0.129204137508798 0.468812935221238 no 1791 0.448598061197846 2633 4589825 SGTC_173 1273-0061 2.693 µM -0.129689693433582 0.468623615248382 no 1792 0.448405968573081 2734 2847414 YPL266W DIM1 SGTC_2347 9049783 174.81 µM -0.130481051574675 0.468315077133488 no 1793 0.448092922313315 2736 6467988 YPL169C MEX67 SGTC_3295 9122362 53.5725 µM -0.130684065186854 0.468235928373306 no 1794 0.448012619183662 2714 4730473 SGTC_1933 st074711 15.9 µM -0.130731164381725 0.468217566025899 no 1795 0.447993989147359 2605 17250958 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.131030430747817 0.468100893999693 no 1796 0.447875617337126 2744 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2317 5986382 200 µM -0.131197905466728 0.468035603478034 no 1797 0.447809376416316 2702 877883 SGTC_1767 st044992 70.3 µM -0.131470743374067 0.467929238643389 no 1798 0.447701464534584 2675 9600693 SGTC_468 gf-109203x 121 µM -0.132107799649746 0.467680893571435 no 1799 0.447449513379254 2715 2396 A protein kinase C inhibitor. SGTC_2453 5731132 22.18 µM -0.132645495121235 0.467471292328782 no 1800 0.44723687520085 2743 1362040 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.13301098916145 0.467328822766523 no 1801 0.447092344815659 2636 229346 A bile salt which induces apoptosis. SGTC_210 3551-0445 56.827 µM -0.133384952689394 0.467183056130286 no 1802 0.44694447254203 2785 2865180 YOR207C RET1 SGTC_697 0508-1955 564 µM -0.134397807429256 0.46678827928332 no 1803 0.446544007662154 2681 6243113 SGTC_2522 biochanin a 4.94 µM -0.134529992475994 0.466736760382099 no 1804 0.446491748041251 2750 5280373 A possible chelator. SGTC_1475 4092-1048 11.7 µM -0.134956909053821 0.466570374169719 no 1805 0.446322972075905 2688 2881759 SGTC_327 1273-0057 3.96 µM -0.137232769304439 0.465683481042518 no 1806 0.44542340488883 2706 3108138 SGTC_1426 4048-4480 71.7 µM -0.138303782977335 0.46526617023641 no 1807 0.445000167930324 2720 14224343 SGTC_904 1141-0088 396 µM -0.139530882247563 0.464788089064871 no 1808 0.444515327057959 2697 1378119 SGTC_1725 st036284 20.55 µM -0.139818720584691 0.464675953809652 no 1809 0.444401610851064 2900 707914 SGTC_158 k038-0087 26.446 µM -0.140534558782757 0.46439709174751 no 1810 0.444118824728355 2649 X158 SGTC_828 2074-0507 139 µM -0.141452348825344 0.46403958288967 no 1811 0.44375630079032 2773 X828 SGTC_1353 1498-1206 8.11 µM -0.141697390080808 0.463944136306874 no 1812 0.443659518277186 2653 6756808 SGTC_2097 5376186 200 µM -0.142720065165278 0.463545814247994 no 1813 0.443255634616453 2718 742755 SGTC_2457 5731572 11.68 µM -0.143312701410193 0.463315004857526 no 1814 0.443021612551563 2803 2865357 SGTC_3294 9122953 26.2835 µM -0.143439918515819 0.463265460216348 no 1815 0.442971379249068 2665 16459826 SGTC_2214 7179297 48.276 µM -0.143578270633176 0.463211579696947 no 1816 0.442916750185201 2655 769744 SGTC_1843 st055809 45.5 µM -0.143716268323522 0.463157837879594 no 1817 0.442862262149705 2798 16413835 SGTC_3342 9147791 14.508 µM -0.14595253734282 0.462287039747739 no 1818 0.441979428403082 2659 1838168 SGTC_2496 diffractaic acid 79.83 µM -0.146505736618006 0.462071652915056 no 1819 0.441761080808477 2902 94870 An apoptosis inducer which activates caspases. SGTC_2402 5553605 200 µM -0.146727396229041 0.461985353385968 no 1820 0.441673596785899 2824 6758546 SGTC_1065 prochlorperazine maleate 2.48 µM -0.14783563521947 0.461553905659718 no 1821 0.4412362427431 2673 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3325 9138760 55.175 µM -0.147956958475384 0.461506676128406 no 1822 0.441188368227533 2695 43844959 SGTC_2439 5492030 7.2 µM -0.148295996043664 0.461374696188696 no 1823 0.44105458755891 2761 5722370 SGTC_574 1315-0397 40 µM -0.148297681414379 0.461374040121204 no 1824 0.441053922546091 2664 6794277 SGTC_329 k048-0121 21.3 µM -0.149223946003098 0.461013487281182 no 1825 0.440688462679592 2745 6832902 SGTC_1626 st003712 1.76 µM -0.150145283428703 0.460654884152271 no 1826 0.440324996944686 2816 24207035 SGTC_1222 0366-0074 1.18 µM -0.15118221279632 0.460251328588332 no 1827 0.439915990573174 2785 286520 SGTC_2349 9023730 187.07 µM -0.152838354481603 0.459606871030355 no 1828 0.439262875274056 2791 4126287 SGTC_2851 9015922 71.43 µM -0.156046931257083 0.458358614897855 no 1829 0.43799801425498 2841 2996893 SGTC_4 0960-0234 25.671 µM -0.156713563042626 0.458099321351639 no 1830 0.437735298700312 2746 6821112 SGTC_2365 9042475 200 µM -0.157236208534993 0.457896045274498 no 1831 0.437529346460223 2762 6464479 SGTC_1669 st015249 58.4 µM -0.15967870983533 0.456946213426503 no 1832 0.436567086389832 2736 722793 SGTC_55 0767-0285 6.563 µM -0.160159985335325 0.456759085427721 no 1833 0.436377524753424 2784 3116166 SGTC_2964 9083345 53.42 µM -0.160745641382502 0.456531385456039 no 1834 0.436146870104106 2729 17741579 SGTC_2817 7995342 71.43 µM -0.160975811686485 0.456441900362809 no 1835 0.436056225821421 2685 18879975 SGTC_3088 9117578 49.47 µM -0.161714155580746 0.456154863614881 no 1836 0.435765478365807 2700 678341 SGTC_246 cycloheximide 667 µM -0.162010251669453 0.456039760450252 no 1837 0.43564889042996 2681 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_567 1080-0542 68.4 µM -0.162899153829152 0.455694234514176 no 1838 0.435298918538063 2689 5950415 SGTC_2963 9082507 9 µM -0.163255538775835 0.45555571320539 no 1839 0.43515861954518 2830 16459611 SGTC_2730 imipramine 71.33 µM -0.163725151748907 0.455373190169521 no 1840 0.434973758246822 2705 3696 A tricyclic antidepressant. SGTC_576 1073-0113 22.7 µM -0.164211009520485 0.455184363231889 no 1841 0.434782517206908 2718 5439563 SGTC_1301 naphtanilide LB 4.81 µM -0.164665147535959 0.455007873221389 no 1842 0.434603775342224 2802 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_859 0439-0102 54.6 µM -0.164737326461634 0.454979823404163 no 1843 0.43457536803715 2687 610143 SGTC_451 chloral hydrate 100 µM -0.165021185328662 0.454869513753215 no 1844 0.434463653588882 2808 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1167 k781-0610 148 µM -0.165500604083343 0.45468321599302 no 1845 0.434274987199805 2763 4525169 SGTC_3264 9137442 49.47 µM -0.166029434509503 0.45447772887038 no 1846 0.434066893125107 2926 17015726 SGTC_1238 0333-0287 48.8 µM -0.166171264743956 0.454422620104091 no 1847 0.434011086219771 2712 7226 SGTC_316 k060-0003 58.6 µM -0.167002740414673 0.454099564228582 no 1848 0.433683946334617 2842 6152314 SGTC_479 n-linoleoylglycine 10 µM -0.167292228166594 0.453987095750873 no 1849 0.433570059496071 2705 6433346 An anti-infammatory. SGTC_1954 st077032 68.9 µM -0.168058675144941 0.453689342357052 no 1850 0.43326855967079 2786 698907 SGTC_738 1315-0003 72.4 µM -0.168969636047054 0.453335481293091 no 1851 0.432910262437801 2854 6251474 SGTC_3173 9105693 49.47 µM -0.169341611260128 0.453190998851913 no 1852 0.43276397376666 2845 17096658 SGTC_3302 9125395 16.351 µM -0.169893204977067 0.452976760486252 no 1853 0.432547062539771 2759 17599668 SGTC_2458 5808907 16.39 µM -0.17037923381879 0.452787998783852 no 1854 0.432355951186821 2722 2731747 SGTC_1721 st082152 9.2685 µM -0.17048374833958 0.452747409295166 no 1855 0.432314857108289 2681 5296051 SGTC_544 k015-0020 52.4 µM -0.17091501613446 0.452579926414688 no 1856 0.432145294615023 2743 3008304 SGTC_3100 9120536 49.47 µM -0.171104491754512 0.452506346209233 no 1857 0.43207080202486 2654 16421196 SGTC_652 0437-0092 114 µM -0.172789860041874 0.451851929085274 no 1858 0.431408303836462 2717 3091274 SGTC_1561 5-methoxyflavone 52.9 µM -0.17443539813825 0.451213103944888 no 1859 0.430761648524217 2706 94525 SGTC_2077 5212015 200 µM -0.175659317148406 0.450738040150789 no 1860 0.430280799226674 2675 780900 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.176649758837538 0.450353652131576 no 1861 0.429891753373625 3065 5282309 SGTC_2196 6573537 42.6665 µM -0.176935183619874 0.450242888092664 no 1862 0.429779651033014 2812 2903087 SGTC_2699 st077704 54.6 µM -0.177283136491464 0.450107864186894 no 1863 0.429642998058605 2775 645852 SGTC_2004 4023728 41.89 µM -0.177379299061771 0.450070549099991 no 1864 0.429605233219553 2810 360084 YDR527W RBA50 SGTC_2255 7941087 197.44 µM -0.178097321626485 0.449791940381545 no 1865 0.429323272720106 2866 935561 SGTC_1505 k297-0037 20.6 µM -0.180563498414969 0.448835198263433 no 1866 0.428355104459524 2744 4089396 SGTC_1574 spiramycin 23.7 µM -0.183010208241335 0.447886302174251 no 1867 0.427395004437568 2699 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2926 9010726 65.15 µM -0.183713485799514 0.447613608237057 no 1868 0.427119114420642 2841 2994293 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.184203638991689 0.447423567319636 no 1869 0.426926852413922 2712 803109 SGTC_2673 kobusone 100 µM -0.184463821021402 0.447322695122658 no 1870 0.426824803371846 2745 6710676 An epoxy ketone and protein crosslinker. SGTC_2306 7482397 179.52 µM -0.185254494841998 0.447016172962229 no 1871 0.426514714014055 2877 891448 SGTC_2545 solidagenone 89.61 µM -0.18572062939107 0.446835480431283 no 1872 0.426331924925875 2688 6708572 An anti ulcer agent SGTC_2186 6124449 200 µM -0.185823998988216 0.446795411704628 no 1873 0.426291391916949 2879 3834182 YLR033W RSC58 SGTC_2029 5175081 200 µM -0.186511223100127 0.446529039710698 no 1874 0.426021939257207 2736 1380876 SGTC_1371 2421-0008 32.7 µM -0.186980821257181 0.446347034648607 no 1875 0.425837835082639 2788 2827552 SGTC_756 0508-1999 28.3 µM -0.188009847684076 0.445948248084629 no 1876 0.425434465753548 2754 6753853 SGTC_3174 9107204 49.47 µM -0.188518944098255 0.445750974206521 no 1877 0.425234933253128 2862 3938802 SGTC_1498 4478-3555 97.6 µM -0.189026563417537 0.445554286071112 no 1878 0.42503599874308 2758 3437919 SGTC_374 0880-0231 82.3 µM -0.189257328357774 0.445464875608191 no 1879 0.424945568953441 2812 6833587 SGTC_43 0570-0105 72.5 µM -0.1897295803825 0.445281909011507 no 1880 0.424760520006714 2743 1114046 YDL195W SEC31 SGTC_77 0828-0286 12.516 µM -0.190461466055451 0.444998374495317 no 1881 0.424473768041733 2706 745345 SGTC_286 k060-0067 22.9 µM -0.193051782492172 0.443995105787162 no 1882 0.423459207108697 2773 5985051 SGTC_1059 3448-6867 171 µM -0.193784129200718 0.443711521619852 no 1883 0.423172457256707 2705 3934407 SGTC_2002 4023503 131 µM -0.194145075588367 0.443571764151264 no 1884 0.423031143906756 2796 4736863 YCR052W RSC6 SGTC_408 cantharidin 100 µM -0.194999739142237 0.443240868741489 no 1885 0.422696575917961 2801 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_296 1222-0039 74.9 µM -0.195006879637645 0.443238104361361 no 1886 0.422693780922507 2779 5984176 SGTC_1723 st034307 2.5525 µM -0.195877870041518 0.442900928832274 no 1887 0.422352879437634 2835 867466 SGTC_763 3453-1109 128 µM -0.196412481397502 0.442693991943544 no 1888 0.422143663892728 2839 1560353 SGTC_3013 9080133 71.4286 µM -0.196568151826029 0.442633738108645 no 1889 0.422082747739682 2947 17050193 SGTC_457 grayanotoxin iii 135 µM -0.197663801860312 0.442209693144916 no 1890 0.421654056401185 2793 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1395 3486-0190 4.35 µM -0.198671457229427 0.441819762831271 no 1891 0.421259876378268 2859 6748079 SGTC_169 k015-0017 16.025 µM -0.19893147534521 0.441719153294005 no 1892 0.421158173891244 2911 1840002 SGTC_1526 st051518 75 µM -0.200254615507316 0.441207245351111 no 1893 0.420640727563114 2820 673993 SGTC_3005 9076496 71.4286 µM -0.201568421633294 0.440699045807905 no 1894 0.420127067175871 2833 21368410 SGTC_2207 7258803 200 µM -0.201572186710343 0.440697589560624 no 1895 0.420125595334134 2852 3666799 SGTC_1960 st011366 51.8 µM -0.201942813392171 0.440554243408441 no 1896 0.419980715636806 2744 3972846 SGTC_650 1328-0195 38 µM -0.202812679910382 0.440217838415051 no 1897 0.419640723383512 2782 2780821 SGTC_3056 9094900 49.47 µM -0.202861868568807 0.440198816886237 no 1898 0.419621499507209 2793 25236784 SGTC_1159 4092-0538 61.2 µM -0.203762382525155 0.439850607548188 no 1899 0.419269595234126 2782 717301 SGTC_348 k064-0012 10.7 µM -0.204691019729695 0.439491572283691 no 1900 0.418906768537821 2733 5066323 SGTC_1803 st050068 52.4 µM -0.204960677048756 0.43938732507032 no 1901 0.418801423965968 2765 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3126 9127922 49.47 µM -0.205597647466471 0.439141094458152 no 1902 0.418552607659829 3032 45595682 SGTC_2666 tannic acid 100 µM -0.206332832125496 0.438856926914685 no 1903 0.418265466968408 2848 16134267 A thiamine antagonist. SGTC_2013 4024628 200 µM -0.206394180256021 0.438833215726581 no 1904 0.41824150822763 2927 5230760 SGTC_2429 5902844 64.44 µM -0.208076630446286 0.438183030853284 no 1905 0.417584567003308 2934 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_978 1416-0512 87.4 µM -0.208264030135055 0.438110620315075 no 1906 0.417511407814817 2834 6814003 SGTC_2853 9015042 58.44 µM -0.210293167376845 0.437326702467761 no 1907 0.416719433853259 2734 6457456 SGTC_516 3992-2719 87.3 µM -0.211843508873173 0.436727923670925 no 1908 0.416114561798888 2725 5350887 YDR037W KRS1 SGTC_2302 7771753 200 µM -0.213327083008151 0.436155067703452 no 1909 0.415535925262518 2859 2203047 SGTC_2815 7968870 71.43 µM -0.215061034728168 0.435485702634955 no 1910 0.414859866422524 2794 2977326 YHR190W ERG9 SGTC_1476 4112-3294 3.34 µM -0.215092998690358 0.435473365173779 no 1911 0.414847406198511 2903 704369 SGTC_2057 5236571 38.335 µM -0.21641334163382 0.434963793766859 no 1912 0.414332783776919 2929 54684039 YBR257W POP4 SGTC_847 0342-0274 5.54 µM -0.217872197386271 0.434400890529794 no 1913 0.413764345027129 2916 18097 SGTC_3124 9127567 49.47 µM -0.220366874697554 0.433438621593677 no 1914 0.412792720733972 3013 17592030 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.221803310823953 0.432884725356247 no 1915 0.412233500995164 2814 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2676 harmalol 100 µM -0.223318400968764 0.432300642654759 no 1916 0.411643853480085 2860 5459187 A monoamine oxidase inhibitor SGTC_1744 st037937 38.9 µM -0.224092015702164 0.432002463253151 no 1917 0.411342852529694 2982 1016152 SGTC_1381 2324-0066 62.1 µM -0.224167656655653 0.431973310540187 no 1918 0.411313424658526 2926 10885928 SGTC_440 fluspirilene 35.1 µM -0.224341906609929 0.431906154429302 no 1919 0.411245635169807 3035 3396 An atypical antipsychotic. SGTC_2413 inermin 26.06 µM -0.224655520529514 0.431785292262377 no 1920 0.411123634772587 3110 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_992 3909-8734 162 µM -0.224963631550653 0.431666557048991 no 1921 0.411003783453548 2850 4288319 SGTC_1772 st048439 82.2 µM -0.225217548397217 0.431568711015056 no 1922 0.410905019231408 2875 2927068 YDL195W SEC31 SGTC_1180 1193-0155 285 µM -0.225566969879378 0.431434069444854 no 1923 0.410769116488323 2949 2921347 SGTC_1902 st060212 70.5 µM -0.225934561635532 0.431292434974165 no 1924 0.410626158225193 2804 688944 SGTC_2961 9083290 32.55 µM -0.227073016924583 0.430853840044287 no 1925 0.410183482703404 2853 17741490 SGTC_113 0099-0221 2.5 µM -0.227539473485439 0.430674160188088 no 1926 0.410002139335845 2979 89219 SGTC_510 ag-490 170 µM -0.227860694034996 0.430550433830732 no 1927 0.409877270264874 2873 5328779 SGTC_2309 7664088 163.95 µM -0.228482111328092 0.430311098337115 no 1928 0.409635730725728 2949 704922 SGTC_922 1866-0035 480 µM -0.230077241455218 0.429696860037481 no 1929 0.409015874611275 2809 3156169 SGTC_1390 3413-2614 145 µM -0.230887107670485 0.429385069096953 no 1930 0.408701253374559 2868 3421432 SGTC_2314 7727897 200 µM -0.234985158881214 0.427808036883947 no 1931 0.407110126119985 2831 900724 SGTC_2727 riluzole 51.77 µM -0.235246488481923 0.42770750956978 no 1932 0.407008712825954 2814 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3193 9111931 49.47 µM -0.237080895169062 0.42700198916568 no 1933 0.406297016674548 2829 17087244 SGTC_911 3456-4043 236 µM -0.238709640141625 0.426375762683782 no 1934 0.405665370539094 2919 914281 SGTC_1269 0831-0796 3.05 µM -0.239090367079838 0.426229405946138 no 1935 0.405517755577062 2942 927758 SGTC_2566 crystal violet carbinol 226 nM -0.240045437969034 0.425862308146204 no 1936 0.405147515886488 3007 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_943 3253-1379 105 µM -0.240143430011249 0.425824646860531 no 1937 0.40510953340381 2996 668464 SGTC_552 k242-0005 476 µM -0.240986239366266 0.425500757876628 no 1938 0.404782890838418 2949 4088318 SGTC_1473 k844-0725 134 µM -0.241212761631241 0.425413714644307 no 1939 0.404695110264673 2863 54682906 SGTC_2532 xanthone 78.9 µM -0.242131687461731 0.425060646397442 no 1940 0.404339062777124 2947 7020 An insecticide. SGTC_2769 toremifene 3.73 µM -0.243200050689829 0.42465023711945 no 1941 0.403925213797837 3025 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3259 9138485 49.47 µM -0.243606773193499 0.424494017044832 no 1942 0.40376769103188 3131 17646153 SGTC_2616 abietic acid 100 µM -0.244093104571947 0.424307235172127 no 1943 0.403579356406781 2949 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2423 st077119 87.2 µM -0.244384514131612 0.424195323693342 no 1944 0.403466517086239 2788 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3148 9097893 49.47 µM -0.245202847667726 0.423881087658897 no 1945 0.403149685782674 2859 17174100 SGTC_1272 0839-0021 27 µM -0.245246118436217 0.423864473242967 no 1946 0.40313293455989 2924 5027250 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.24587775786483 0.423621961883324 no 1947 0.402888431010577 2905 688761 SGTC_2374 9071832 200 µM -0.24632955911269 0.42344851525439 no 1948 0.402713564948828 2806 17381698 SGTC_1332 1480-0653 17.5 µM -0.25168152368792 0.421395032049092 no 1949 0.400643619670541 2976 5749438 SGTC_1118 chelidonine 707.474 nM -0.251823321475941 0.421340654778301 no 1950 0.40058881508657 2982 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2985 9022375 71.43 µM -0.251907322997132 0.421308442194446 no 1951 0.400556349576269 3047 4939335 SGTC_249 wiskostatin 11.211 µM -0.252108891088816 0.421231147777954 no 1952 0.400478448897163 2864 2775510 A n-wasp and actin depolymerizer. SGTC_2907 7721985 69.9 µM -0.252522459055209 0.421072568222445 no 1953 0.400318628330163 2909 3267881 SGTC_2713 st079149 53.4 µM -0.252647299274066 0.421024701685328 no 1954 0.400270387943099 2932 3103253 SGTC_1444 4112-3581 28 µM -0.252697513585487 0.421005448722386 no 1955 0.400250984706865 2852 2877249 SGTC_2900 5328528 85.29 µM -0.252725622676003 0.420994671333998 no 1956 0.400240123223138 2848 795359 SGTC_2897 9048598 12.99 µM -0.255181823970805 0.420053161519794 no 1957 0.399291334416132 2860 6467404 SGTC_190 3970-0790 3.722 µM -0.255838447438354 0.419801542200061 no 1958 0.399037792418429 2921 2832352 SGTC_2479 5617353 43.85 µM -0.256045430813157 0.419722232581101 no 1959 0.39895787875841 3013 2731746 SGTC_779 1360-0071 233 µM -0.256479727885041 0.419555833994934 no 1960 0.398790215927812 3050 7566 SGTC_2873 9040596 71.43 µM -0.256772865387605 0.41944352806704 no 1961 0.39867705909852 2970 6463863 SGTC_2909 7941780 10.49 µM -0.257873798599574 0.419021800632778 no 1962 0.398252153405859 2974 1243215 SGTC_736 0958-0254 92.6 µM -0.258065023709008 0.418948558723917 no 1963 0.398178362265555 2979 6812352 SGTC_366 0181-0206 4.31 µM -0.26023730555655 0.418116741993647 no 1964 0.397340364815977 3034 274874 SGTC_2425 5628681 7.85 µM -0.261490414395505 0.417637064047652 no 1965 0.396857170326216 2951 5714958 SGTC_1786 berberine 21.6 µM -0.261551196381027 0.417613800401337 no 1966 0.396833737019948 2868 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1363 1636-0063 10.4 µM -0.262539628504434 0.417235529243339 no 1967 0.396452718682486 2879 6072185 SGTC_1832 st054113 55 µM -0.263507511145467 0.416865196551083 no 1968 0.396079717506415 2983 1251267 SGTC_1357 1503-1303 39.5 µM -0.263607957521104 0.416826767828822 no 1969 0.396041013073616 2888 292895 SGTC_2630 antimycin a 100 µM -0.263772956362978 0.41676364438268 no 1970 0.395977437229282 2810 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1914 st062367 72.6 µM -0.264023214674206 0.416667907400897 no 1971 0.395881015267601 2871 978205 SGTC_1525 8-methoxypsoralen 92.5 µM -0.264379095093981 0.416531772913788 no 1972 0.395743909163072 3133 4114 Related to psoralen; DNA damaging agent. SGTC_2767 sibutramine 71.45 µM -0.264470651893547 0.416496751425338 no 1973 0.39570863817531 3067 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_272 doxorubicin 8.13 µM -0.264496657068461 0.416486804279177 no 1974 0.395698620197916 2850 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3321 9137793 26.8275 µM -0.265124650781552 0.416246608911173 no 1975 0.395456719025158 2875 4904192 SGTC_418 lividomycin a 100 µM -0.266835571720795 0.415592373889931 no 1976 0.39479788232183 2984 72394 An antibiotic. SGTC_280 3448-3607 3.04 µM -0.267197206437695 0.41545411912857 no 1977 0.39465866346301 2977 626179 SGTC_2397 5161689 200 µM -0.267241158186957 0.41543731686794 no 1978 0.394641744232998 3089 2259942 SGTC_1695 st026914 34.495 µM -0.267435255139937 0.415363117630102 no 1979 0.39456702896973 2861 3289191 SGTC_2079 5212404 121 µM -0.268527787787992 0.414945521448273 no 1980 0.394146544232079 3003 758462 SGTC_515 4092-1064 102 µM -0.268820815504945 0.414833534475981 no 1981 0.394033787157183 3126 717353 SGTC_1754 st042065 16.137 µM -0.26940691396991 0.414609564859391 no 1982 0.393808283106514 2922 1126236 YIL048W NEO1 SGTC_3318 9139014 38.6185 µM -0.269937978887534 0.414406649538073 no 1983 0.393603984207877 2862 16643984 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.271029846806677 0.413989528046481 no 1984 0.393184038329056 2928 2374 Ca(2+)-ATPase inhibitor. SGTC_3197 9113331 49.47 µM -0.271535522632387 0.413796379778381 no 1985 0.392989591235647 3104 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1257 0669-0121 16 µM -0.271806792087413 0.413692774111269 no 1986 0.392885291223239 2981 4307855 SGTC_612 0302-0167 22.4 µM -0.272580268899911 0.413397393910063 no 1987 0.392587940455859 2962 235821 SGTC_2142 5622915 118.518 µM -0.273654918073265 0.412987081488146 no 1988 0.392174912884588 2926 5322196 SGTC_2638 epoxomicin 18 µM -0.273687202600673 0.412974756382293 no 1989 0.392162506619055 2995 9915668 A protesome inhibitor. SGTC_2812 7970281 58.44 µM -0.274977819555936 0.412482114254019 no 1990 0.391666639551314 3030 2233435 SGTC_1160 4092-0570 10.5 µM -0.275990588363492 0.412095626182573 no 1991 0.391277647501204 2892 4994975 SGTC_884 0851-0618 334 µM -0.276629689637743 0.411851779202855 no 1992 0.391032232481573 3037 9642473 SGTC_1764 st044502 93.5 µM -0.277435993175779 0.411544185319298 no 1993 0.390722673664261 3030 8407 SGTC_2649 anisomycin 9.56 µM -0.278847522404204 0.411005837007692 no 1994 0.39018092134237 2957 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3033 9090887 49.47 µM -0.27890776649952 0.410982864012548 no 1995 0.390157804079221 2893 19325384 SGTC_114 0364-0001 490.298 µM -0.282514867926793 0.40960792029498 no 1996 0.388774373879984 2968 4003655 SGTC_2062 5245942 200 µM -0.282839427625028 0.409484259865965 no 1997 0.388649964476649 2877 1376160 SGTC_2440 5628896 157.78 µM -0.283385616881532 0.409276176735551 no 1998 0.388440626377422 2909 5522048 SGTC_1334 1486-0610 236 µM -0.285075153303277 0.408632671748662 no 1999 0.387793282683432 2997 3742339 SGTC_1420 4'-methoxyflavone 42 µM -0.285351904220599 0.4085272872102 no 2000 0.387687275594184 2989 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1134 3477-0009 42.5 µM -0.285849179188935 0.408337945499367 no 2001 0.387496819678903 3162 3973534 SGTC_344 k064-0035 6.43 µM -0.286146267586017 0.408224836750771 no 2002 0.387383047975097 2909 5088750 SGTC_2661 dactinomycin 12.96 µM -0.286884947503965 0.407943636575188 no 2003 0.387100208206742 2942 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3256 9138902 49.47 µM -0.288418392014468 0.407360037474468 no 2004 0.386513245413397 2914 17228773 SGTC_2788 5282734 71.43 µM -0.289033867118577 0.40712585738295 no 2005 0.386277730424171 3075 743706 SGTC_1611 st001856 99.4 µM -0.289621127807419 0.406902443447892 no 2006 0.386053050893648 2939 647478 SGTC_2126 5251174 33.877 µM -0.291352899749874 0.406243795151316 no 2007 0.385390716597669 3085 790722 SGTC_1370 2001-0092 44.6 µM -0.292037767149002 0.405983391240747 no 2008 0.385128873985396 3148 790957 SGTC_3254 9136651 49.47 µM -0.292076987201774 0.405968480042491 no 2009 0.38511388072374 2956 16454030 SGTC_611 3453-1652 23.7 µM -0.292244478378975 0.405904802567495 no 2010 0.385049853190655 3025 1560575 SGTC_1008 4106-0037 6 µM -0.295518557141861 0.404660551990687 no 2011 0.383798889231775 2878 2905394 SGTC_800 3448-7362 155 µM -0.296650499853214 0.404230602449234 no 2012 0.383366676006622 3008 15991913 SGTC_776 4476-4378 112 µM -0.29733795074658 0.403969542115522 no 2013 0.383104255274629 3011 2892008 SGTC_2551 apiole 73.87 µM -0.297670325507507 0.403843337715539 no 2014 0.382977397035362 2894 10659 A possible DNA adduct former. SGTC_1581 himbacine 57.9 µM -0.298238037888334 0.403627797571482 no 2015 0.38276074597857 2927 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1465 k213-0056 144 µM -0.298345179988325 0.403587122818016 no 2016 0.382719862398585 2904 24048857 YMR208W ERG12 SGTC_502 l-744,832 89.3 µM -0.300159055448354 0.402898673138919 no 2017 0.382027917448584 3045 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2417 cerulenin 830 nM -0.300365197767786 0.402820451592971 no 2018 0.381949303464818 3037 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3080 9117754 49.47 µM -0.300989565506252 0.402583556445297 no 2019 0.381711225660926 3155 9550191 SGTC_2038 4100038 30.985 µM -0.30138826020876 0.4024323039773 no 2020 0.381559222692839 3040 3596803 SGTC_1878 temozolomide 1 mM -0.301693956650613 0.402316342070974 no 2021 0.381442687823866 3035 5394 DNA alkylating agent. SGTC_885 0865-0106 16.8 µM -0.302225569048358 0.402114702409663 no 2022 0.381240056891936 2943 2793380 SGTC_3178 9107506 49.47 µM -0.302319678319952 0.402079009638222 no 2023 0.381204189317517 3079 8897194 SGTC_2585 alliin 100 µM -0.303745601609127 0.401538300583053 no 2024 0.380660856636508 3131 87310 A garlic compound which reacts with lipids. SGTC_826 1683-5028 118 µM -0.30385126658115 0.40149823999172 no 2025 0.380620603490217 3020 722377 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.304546174376826 0.401234806524522 no 2026 0.380355910087199 2957 2724 A muscle relaxant with antifungal properties. SGTC_1172 0370-0043 85 µM -0.304716522654897 0.401170235828802 no 2027 0.380291032230635 3084 376585 SGTC_2850 9015429 58.44 µM -0.305423096005353 0.40090243728628 no 2028 0.380021966776834 2997 6457570 SGTC_1692 fluoroquinolonic acid 71 µM -0.305545890297101 0.400855901736471 no 2029 0.37997521222535 3064 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2208 7283366 200 µM -0.306458128976068 0.400510233270102 no 2030 0.379627927670864 3035 898663 SGTC_2689 tacrolimus 100 µM -0.307404357562271 0.400151767550619 no 2031 0.379267805904815 3016 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2780 5215298 71.43 µM -0.307613303199294 0.400072622688735 no 2032 0.379188298136387 3097 2834131 SGTC_3140 9094243 49.47 µM -0.307936880051091 0.399950065677819 no 2033 0.379065181107355 2984 19291112 SGTC_1731 st035964 63 µM -0.307943791606041 0.399947447985166 no 2034 0.379062551479114 2959 6739575 SGTC_2475 5812728 15.03 µM -0.308437501512218 0.399760471195462 no 2035 0.378874724947907 2925 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1068 loratadine 26.9 µM -0.309029058684699 0.39953646816196 no 2036 0.378649711162229 2993 3957 A H1 histamine antagonist. SGTC_2657 nystatin 74.44 µM -0.311366915344201 0.398651523804662 no 2037 0.377760851203354 3016 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3232 9132874 49.47 µM -0.31142546125966 0.398629369198563 no 2038 0.377738600157779 2962 3784940 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.311426481236151 0.398628983227864 no 2039 0.377738212507629 2986 66535 A nucleotide analog. SGTC_545 4218-0007 221 µM -0.311633425044537 0.398550675389609 no 2040 0.377659564420439 3068 2840508 SGTC_1675 st018485 24.5 µM -0.312032087134965 0.398399832590192 no 2041 0.377508068939784 3008 3323024 SGTC_940 3232-1287 54.8 µM -0.312477285575588 0.398231399654076 no 2042 0.377338911465507 2985 1585493 YIL048W NEO1 SGTC_2482 5981709 142.65 µM -0.312998197886834 0.398034345790609 no 2043 0.377141015646007 2991 877755 SGTC_1793 st048256 72.231 µM -0.314409682980339 0.397500531499726 no 2044 0.376604951409713 2934 672022 SGTC_2976 9009005 19.48 µM -0.315171148992256 0.397212629732267 no 2045 0.376315854927669 3160 2993148 SGTC_1209 2323-2347 50.3 µM -0.315319012485859 0.397156730689859 no 2046 0.376259725443267 3057 5412760 SGTC_1192 1488-0095 21.4 µM -0.31591030107447 0.396933218169223 no 2047 0.376035296453836 3040 915875 SGTC_774 k060-0086 136 µM -0.317189632658785 0.396449735022444 no 2048 0.375549858012447 3140 5911235 SGTC_2244 6635614 200 µM -0.317559231377322 0.396310086412844 no 2049 0.375409651549831 2886 836499 SGTC_986 1493-0483 84 µM -0.319112272096106 0.395723433490414 no 2050 0.374820689003353 3081 40079 SGTC_2285 7945142 200 µM -0.320149642823033 0.395331703651342 no 2051 0.37442744743694 3084 2970608 SGTC_2338 7999974 200 µM -0.321336167112939 0.394883780401867 no 2052 0.373977825559946 3028 315925 SGTC_1265 0819-1001 68.8 µM -0.321693714329455 0.394748830422098 no 2053 0.373842370088669 2982 3106768 SGTC_1076 itraconazole 331 nM -0.32270873818962 0.394365796174509 no 2054 0.373457916909064 2992 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1385 3091-4834 14.1 µM -0.324346603931756 0.393747938832904 no 2055 0.372837820114391 3063 4072814 SGTC_1464 k208-0027 110 µM -0.324462565826218 0.393704204273828 no 2056 0.372793929349102 3171 X1464 SGTC_3204 9114183 49.47 µM -0.325103854457549 0.39346236908682 no 2057 0.372551235923658 2916 17027248 SGTC_2835 9006588 71.43 µM -0.325893262799069 0.393164733182519 no 2058 0.372252556595191 3192 2345538 SGTC_653 0203-0016 55.2 µM -0.326605458918655 0.392896262686776 no 2059 0.371983157084544 3020 295302 SGTC_1448 4255-0083 152 µM -0.327375355152051 0.392606098772158 no 2060 0.371692002068786 3131 5399660 SGTC_2937 9044753 11.33 µM -0.327681793346853 0.392490622783286 no 2061 0.371576135406538 2931 6465530 YGL099W LSG1 SGTC_2968 9090663 33.37 µM -0.327917491725547 0.392401810322314 no 2062 0.371487023933402 3035 25236811 SGTC_894 0960-0238 55.9 µM -0.328864682904096 0.392044959966206 no 2063 0.371128984893225 3088 6741907 YDL195W SEC31 SGTC_582 0987-0078 156 µM -0.329441713738572 0.391827610466915 no 2064 0.370910921406299 3115 1625765 SGTC_2934 9036370 36.88 µM -0.32951030608503 0.391801776115104 no 2065 0.370885002693573 3084 6462800 SGTC_1558 st069300 45.6 µM -0.330505413987296 0.391427036306725 no 2066 0.370509051243858 3098 24208000 SGTC_180 1486-1293 102.781 µM -0.330906822017156 0.391275901730233 no 2067 0.370357434391041 3126 4140536 SGTC_1392 3455-1037 33.9 µM -0.331553469002882 0.391032466494714 no 2068 0.370113230065381 3146 981132 SGTC_1438 4092-1045 4 µM -0.333523622040669 0.39029105074642 no 2069 0.369369530693076 2996 1351342 SGTC_2141 5621638 7.665 µM -0.334782077329225 0.389817672460694 no 2070 0.368894740678803 3119 2856238 SGTC_705 1124-0212 310 µM -0.341557236537739 0.38727196486536 no 2071 0.366342061973773 3164 9554485 SGTC_313 3474-0040 5.03 µM -0.34163757508777 0.387241807173299 no 2072 0.366311827987842 2979 1043375 YIL048W NEO1 SGTC_3253 9135987 49.47 µM -0.341667205254005 0.387230684696869 no 2073 0.36630067741067 3120 4182430 SGTC_3 0833-0587 95.581 µM -0.345507960896298 0.385789741090312 no 2074 0.364856263212497 3066 5382644 SGTC_314 1671-0008 2.74 µM -0.346593333369067 0.385382824317558 no 2075 0.364448427512043 3014 3913060 SGTC_1895 st058434 18.3 µM -0.347650769015365 0.384986502642682 no 2076 0.364051236771088 3168 5393175 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.348621551379355 0.384622763939797 no 2077 0.363686722994537 3119 140250 A respiratory chain inhibitor. SGTC_2210 7115885 190.385 µM -0.348656949200757 0.384609502783429 no 2078 0.363673433988505 3035 2927039 SGTC_214 4373-3496 70 µM -0.348998803826323 0.384481440054436 no 2079 0.363545103793085 3071 3779166 SGTC_2426 5582046 32.21 µM -0.349231975115778 0.38439409860117 no 2080 0.363457581458028 3198 2251934 SGTC_3038 9091290 49.47 µM -0.349684296920416 0.384224684344086 no 2081 0.363287819900693 3174 25236843 SGTC_1659 st012954 42.1 µM -0.349835069636141 0.384168218294696 no 2082 0.363231239137363 3141 24207262 SGTC_2116 5511452 16.8835 µM -0.351510842795706 0.383540788477567 no 2083 0.362602569733414 3142 870744 SGTC_1011 4112-3381 17.4 µM -0.351598910461549 0.383507823302851 no 2084 0.362569541211126 3178 2877139 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.353248857097799 0.382890377293782 no 2085 0.361950941560648 2980 6312947 SGTC_1463 k081-0032 34.1 µM -0.35349007276953 0.382800134016451 no 2086 0.361860534902926 3087 977755 SGTC_1836 st055642 81 µM -0.354642076960217 0.382369235611015 no 2087 0.361428874789221 3045 8571 SGTC_1730 st033808 45.1 µM -0.355720354181956 0.381966046138993 no 2088 0.361025000179445 3023 1045166 SGTC_1690 st023502 41.2 µM -0.356127684354661 0.381813770502964 no 2089 0.360872472726565 3128 24207482 SGTC_2190 6049624 200 µM -0.356202400936192 0.381785840564064 no 2090 0.360844497013583 3115 2265554 SGTC_2927 9011802 47.9 µM -0.357581207183862 0.381270537136274 no 2091 0.360328372065488 3124 43912568 SGTC_3185 9108267 49.47 µM -0.358223912337886 0.38103040977631 no 2092 0.360087876800219 3114 4910486 SGTC_2903 5923464 63.88 µM -0.35888179170459 0.380784660471504 no 2093 0.359841760802934 3132 2876576 SGTC_245 methotrexate 289.6 µM -0.359381430342631 0.380598053745547 no 2094 0.359654882276609 3113 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1098 clofazimine 15.1 µM -0.361713873621907 0.379727293108529 no 2095 0.358782929227436 3165 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_423 5-fluorouracil 457 µM -0.362701301346943 0.379358844504359 no 2096 0.358414013746982 2961 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1453 4237-0541 195 µM -0.364319934140043 0.378755105253836 no 2097 0.357809557973961 3180 739892 SGTC_1762 st045503 25.4615 µM -0.366221325328296 0.378046276833105 no 2098 0.357099965289647 3117 4645554 SGTC_2416 tofa 880 nM -0.368035072337549 0.377370504021255 no 2099 0.356423541392518 3044 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_526 4469-0568 170 µM -0.369132631508864 0.3769617533496 no 2100 0.356014433689637 3046 2901964 SGTC_147 4466-0538 29.23 µM -0.36930672292117 0.37689693124843 no 2101 0.355949557518078 3266 6742687 YHR072W ERG7 SGTC_2351 9026858 72.31 µM -0.370479753924974 0.376460249329544 no 2102 0.355512529550143 2993 1409300 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.372284551544833 0.375788689752597 no 2103 0.35484049971261 3001 688667 SGTC_807 1315-0151 48 µM -0.373125582367344 0.375475873131838 no 2104 0.354527489688141 3267 4011080 SGTC_1292 0kpi-0043 232 µM -0.373494390430351 0.37533872287969 no 2105 0.354390259785172 3103 3333905 SGTC_1906 st060206 94.7 µM -0.37363817744075 0.375285256449078 no 2106 0.354336763153529 3189 5133468 SGTC_1804 st050076 49.1 µM -0.373768025755868 0.375236975106389 no 2107 0.354288454948406 3164 3895976 SGTC_1978 st071761 42 µM -0.375062640232752 0.374755707166657 no 2108 0.353806940511238 3060 5147680 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.375477009883919 0.374601708005627 no 2109 0.353652870642518 2978 5711223 A potent inhibitor of glutathione S-transferases. SGTC_474 dl-dihydrosphingosine 5 µM -0.376935161176932 0.374059949880936 no 2110 0.35311089527337 3213 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1440 4100-1550 40 µM -0.378537309409288 0.373464978183433 no 2111 0.352515741570531 3110 742806 SGTC_2644 guaiazulene 100 µM -0.379128284232417 0.373245590579384 no 2112 0.352296301816355 3149 3515 A coloring agent. SGTC_36 0335-0881 14.2 µM -0.379388287382317 0.373149082611393 no 2113 0.352199773462584 3109 23828853 SGTC_3082 9117008 49.47 µM -0.381104663034634 0.372512198236702 no 2114 0.351562793729712 3107 41448529 SGTC_1358 1509-0022 2.48 µM -0.381329738902737 0.372428706600782 no 2115 0.351479294640449 3139 3258434 SGTC_1352 1496-0991 99 µM -0.381891623967804 0.372220302150534 no 2116 0.351270876694768 3067 3000039 SGTC_225 nsc-122657 1.016 µM -0.382176195963946 0.372114768020067 no 2117 0.351165338513701 3178 275685 SGTC_1915 st067105 30.6 µM -0.382285835275684 0.372074110610801 no 2118 0.351124680043404 3111 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2597 laccaic acid a 100 µM -0.382866200288871 0.371858918342823 no 2119 0.350909486787557 3184 5491415 A textile dye. SGTC_2801 7907800 81.82 µM -0.385047495193278 0.371050479228396 no 2120 0.350101113582288 3169 6620925 SGTC_824 1304-0008 100 µM -0.386941943683184 0.370348813454833 no 2121 0.349399594277384 3097 768245 SGTC_2772 vinpocetine 57.06 µM -0.389964677559824 0.36923014699071 no 2122 0.348281333237972 3273 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1111 tnp00062 510.699 nM -0.392682173696388 0.368225388361374 no 2123 0.347277119271262 3248 676306 SGTC_2887 9044784 58.44 µM -0.393927365292655 0.367765295526196 no 2124 0.346817332987514 3093 6465546 SGTC_2805 7950783 58.44 µM -0.394118322280714 0.367694754515379 no 2125 0.346746842154438 3203 1178958 YDL195W SEC31 SGTC_363 0455-0021 3.06 µM -0.396064826782709 0.366975955459161 no 2126 0.346028602612448 3073 4597466 SGTC_3218 9131285 49.47 µM -0.3985832646376 0.366046646551263 no 2127 0.345100147407559 3275 17156417 SGTC_2794 7785382 27.27 µM -0.399069727708283 0.365867230969428 no 2128 0.344920913596224 3218 2205081 SGTC_2219 9098279 200 µM -0.399397502401198 0.365746358808689 no 2129 0.3448001669903 3199 902349 SGTC_1481 3346-2004 36 µM -0.399403218728231 0.365744250939869 no 2130 0.344798061333127 3199 2770522 SGTC_3023 9089636 49.47 µM -0.401684553740847 0.36490334356974 no 2131 0.343958096803111 3225 17249241 SGTC_3220 9131269 49.47 µM -0.402830880782872 0.364481048635608 no 2132 0.343536320950109 3196 17722206 SGTC_1949 st076024 69.1 µM -0.403916881160429 0.364081129070355 no 2133 0.343136921106316 3057 2921930 SGTC_3217 9129673 49.47 µM -0.405269499315784 0.363583234481459 no 2134 0.34263971186516 3281 17248312 SGTC_2229 7354935 190 µM -0.407423056306479 0.362790992310304 no 2135 0.341848647904442 3189 318112 SGTC_3072 9116419 49.47 µM -0.407865984990609 0.362628122093541 no 2136 0.341686033268411 3154 17170162 SGTC_3113 9123498 49.47 µM -0.408229591104417 0.362494438316351 no 2137 0.341552562680225 3201 8897275 SGTC_270 tamoxifen 5.46 µM -0.408909722174287 0.362244425682063 no 2138 0.341302956998894 3321 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1839 st053978 48 µM -0.410455617771735 0.361676381201001 no 2139 0.340735877141937 3208 3788398 SGTC_840 0245-0196 390 µM -0.411721895983471 0.36121130999 no 2140 0.340271637093914 3263 3827528 SGTC_1596 piperlongumine 63 µM -0.412026877103249 0.361099328933885 no 2141 0.340159861740857 3260 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.412957596284648 0.360757666922123 no 2142 0.339818840721815 3255 61125 An anti-inflammatory. SGTC_2401 5128683 200 µM -0.414242909535979 0.360286018037011 no 2143 0.339348109833608 3123 708373 SGTC_1763 st044482 94.5 µM -0.414853481034508 0.360062041732165 no 2144 0.339124582936409 3228 88505 SGTC_2113 5491891 107.031 µM -0.415547667233407 0.359807451348016 no 2145 0.33887051392859 3174 789979 SGTC_1903 st060211 78.3 µM -0.415574163538061 0.359797735151539 no 2146 0.338860817852219 3281 688960 SGTC_3255 9139072 49.47 µM -0.415818402047746 0.359708177143334 no 2147 0.338771446068721 3207 17646060 SGTC_3319 9138450 16.7555 µM -0.416888844500677 0.35931575546092 no 2148 0.338379856760718 3122 2029690 SGTC_2333 9017922 200 µM -0.417883415149544 0.358951281139987 no 2149 0.338016179445639 3253 3163164 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.418324391634332 0.35878972019723 no 2150 0.337854979164414 3123 16623 A steroid. SGTC_709 3807-1509 243 µM -0.419100617589892 0.358505394994219 no 2151 0.337571299680527 3204 1886677 YPL242C IQG1 SGTC_212 3807-4682 38.772 µM -0.421683573986762 0.357559844627307 no 2152 0.336627997768149 3221 3125501 YBL034C STU1 SGTC_300 r073-0011 5.04 µM -0.421713286264536 0.35754897283907 no 2153 0.336617152736775 3253 2735780 SGTC_70 0141-0289 43.283 µM -0.422541159194374 0.357246098810206 no 2154 0.336315032394163 3181 352408 SGTC_669 0108-0021 26.2 µM -0.42536507346505 0.356213658447751 no 2155 0.33528528138578 3453 17201 SGTC_201 4262-0159 12.803 µM -0.426138263999331 0.355931158590001 no 2156 0.335003549823809 3196 1341029 SGTC_2481 5478948 45.16 µM -0.42663762827393 0.355748748382608 no 2157 0.334821643116831 3283 77792 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.427198297171429 0.355543983881117 no 2158 0.334617450752205 3235 279621 SGTC_3344 9148862 3.898 µM -0.427604288480392 0.35539573592013 no 2159 0.334469621592381 3301 4905352 SGTC_1457 k015-0032 57.3 µM -0.427897102337898 0.355288828348962 no 2160 0.334363018422908 3182 4302660 SGTC_1996 st072960 66.8 µM -0.428026714170218 0.355241510159185 no 2161 0.334315835602719 3275 1719405 SGTC_629 3448-6466 76.7 µM -0.428488985724597 0.3550727640159 no 2162 0.334147575407062 3202 573744 SGTC_3079 9117512 49.47 µM -0.428593259386202 0.355034704216199 no 2163 0.334109625899631 3212 7185044 SGTC_1683 st010134 710 nM -0.430707739678458 0.354263233189345 no 2164 0.333340445235625 3115 3818134 SGTC_942 3253-1115 227 µM -0.430793609802058 0.354231915965532 no 2165 0.333309223192408 3333 46497897 SGTC_290 2043-6722 48.1 µM -0.430849690632999 0.354211463564078 no 2166 0.33328883304367 3252 773758 YLR208W SEC13 SGTC_1504 k297-0033 30 µM -0.432892322242043 0.353466812947774 no 2167 0.332546499024707 3101 4388117 SGTC_3108 9121785 49.47 µM -0.435015981099797 0.352693217740148 no 2168 0.331775413751878 3244 17140271 SGTC_619 1652-1634 108 µM -0.438810186863422 0.351312601582721 no 2169 0.330399539203681 3184 5400454 SGTC_1197 1601-0112 267 µM -0.439324476466486 0.351125614934864 no 2170 0.330213220636788 3153 7350313 SGTC_1518 st038567 90.8 µM -0.440343351890701 0.350755276219711 no 2171 0.329844223358298 3255 77966 SGTC_2264 7948757 110.76 µM -0.441503383442973 0.350333802961738 no 2172 0.329424306305886 3105 2971411 SGTC_706 4262-0057 46.9 µM -0.442064630066531 0.350129951809711 no 2173 0.329221219129939 3177 883298 SGTC_1089 terbinafine 2.25 µM -0.442698090014624 0.349899923825353 no 2174 0.328992062075886 3276 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_690 glyoxal 20.3 µM -0.442856803181436 0.349842299020238 no 2175 0.328934656919999 3247 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1093 fluphenazine 7.97 µM -0.442978151126196 0.34979824293131 no 2176 0.328890769157788 3200 6602611 An atypical antipsychotic. SGTC_527 4476-4215 268 µM -0.443201456060547 0.349717176039655 no 2177 0.328810012901682 3170 4418754 SGTC_726 3448-4391 34.2 µM -0.443334187015869 0.349668993669349 no 2178 0.328762015711443 3380 1356692 SGTC_598 3937-0236 20.2 µM -0.443356072333105 0.3496610493613 no 2179 0.328754101975466 3250 1379313 SGTC_431 k089-0097 107 µM -0.446042327784505 0.348686447164766 no 2180 0.327783335428855 3237 5499420 SGTC_830 4076-0286 57.8 µM -0.446145461396808 0.348649049035972 no 2181 0.327746087850226 3193 6866659 SGTC_1139 k015-0024 46.9 µM -0.446538144138683 0.348506668575649 no 2182 0.327604282836321 3293 2766652 SGTC_2118 5526350 200 µM -0.446549741125912 0.348502464018521 no 2183 0.327600095327251 3275 743594 SGTC_2154 5570129 200 µM -0.447370283841959 0.348205018621257 no 2184 0.327303863962067 3275 673366 SGTC_1324 1418-0026 34.4 µM -0.447514649872491 0.348152695821881 no 2185 0.327251756350226 3265 1372513 SGTC_553 k007-0256 45.7 µM -0.447626853092198 0.348112031834904 no 2186 0.327211259938679 3228 6287000 SGTC_1904 st060225 78 µM -0.447939468148216 0.347998745059629 no 2187 0.327098441570447 3278 66595 SGTC_1351 1496-0003 46.5 µM -0.448452879672141 0.347812722242348 no 2188 0.326913192866607 3316 3891978 SGTC_2332 7982454 138.89 µM -0.449121781970333 0.347570415884327 no 2189 0.326671904098131 3278 2981748 SGTC_1640 st009078 66.4 µM -0.449709929071197 0.347357414111214 no 2190 0.326459805503019 3280 690618 SGTC_1085 doxorubicin 7.67 µM -0.449731481476498 0.347349609665087 no 2191 0.326452034303462 3307 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_220 paclitaxel 373.376 µM -0.449803558434424 0.347323509998059 no 2192 0.326426045898803 3266 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1275 0867-0008 21.1 µM -0.450361142792754 0.347121628527202 no 2193 0.326225029155908 3141 3422836 SGTC_3316 9136639 10.545 µM -0.450933110359026 0.346914584477655 no 2194 0.326018879512983 3282 4903665 SGTC_2971 9092186 9.93 µM -0.45132428417514 0.346773011481214 no 2195 0.325877922508002 3142 25236400 SGTC_678 1218-2179 85.9 µM -0.452957172712513 0.346182270323447 no 2196 0.325289790401528 3262 6820081 YOR116C RPO31 SGTC_3222 9128301 49.47 µM -0.453473159521282 0.345995675987446 no 2197 0.32510403316053 3173 4911358 SGTC_970 1315-0089 19.5 µM -0.455721603629307 0.34518301670916 no 2198 0.32429509242456 3280 6811083 YLR033W RSC58 SGTC_2022 5136654 200 µM -0.456370680529265 0.344948552182621 no 2199 0.324061722790074 3301 1713771 SGTC_2718 lomofungin 53.02 µM -0.457988406418583 0.344364444065635 no 2200 0.323480385290166 3333 5351222 A RNA synthesis inhibitor. SGTC_1316 1272-0050 65.9 µM -0.459145225916691 0.343946981644441 no 2201 0.323064940650817 3269 7340392 SGTC_2449 5812982 45.77 µM -0.459621882518358 0.343775025466837 no 2202 0.322893824742488 3290 776185 SGTC_1276 0871-0068 94.2 µM -0.459716688461803 0.343740827615335 no 2203 0.322859794635163 3253 3414906 SGTC_2940 9060638 45.86 µM -0.460404537584392 0.343492748965246 no 2204 0.322612939150578 3281 4027022 SGTC_2755 lomerizine 42.69 µM -0.462945495582486 0.342576915898424 no 2205 0.321701717840986 3223 3949 A calcium channel blocker. SGTC_685 1278-0033 54.9 µM -0.464554753064326 0.34199737189112 no 2206 0.321125170500508 3344 3590572 SGTC_288 1315-0019 35.1 µM -0.464935320488216 0.341860371993096 no 2207 0.320988887876492 3327 6811474 SGTC_3348 9149464 3.537 µM -0.466597555117307 0.341262230927805 no 2208 0.320393918267128 3265 1951442 SGTC_2656 pseudo-anisatin 100 µM -0.466959873323783 0.341131906645124 no 2209 0.320264293596236 3256 6708809 A neurotoxin. SGTC_716 1683-5115 658 µM -0.468203084100671 0.340684873281413 no 2210 0.319819683439868 3336 723597 SGTC_785 1270-0111 65.3 µM -0.469492955584188 0.340221298083548 no 2211 0.319358659465368 3200 6741994 SGTC_2147 5545932 89.7195 µM -0.469616559321604 0.340176888005799 no 2212 0.31931449584358 3280 797404 SGTC_2072 5231554 129 µM -0.470351193079294 0.339912984289127 no 2213 0.31905206407645 3365 789545 SGTC_1706 st031321 9.9705 µM -0.470671647110666 0.339797891610523 no 2214 0.318937617308808 3327 6103185 SGTC_1414 3917-0015 5.4 µM -0.470947827184721 0.339698712126721 no 2215 0.318838996364574 3311 6618702 SGTC_100 0086-0128 49.5915 µM -0.472634194229348 0.339093359045868 no 2216 0.318237091252291 3270 93297 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.472911065502318 0.338994010546098 no 2217 0.318138315004963 3141 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1327 1436-0082 2.18 µM -0.473157222643528 0.338905692464788 no 2218 0.318050507152582 3233 15992205 SGTC_2370 9071495 200 µM -0.474031611460756 0.338592044386999 no 2219 0.317738682582638 3300 21791103 SGTC_2664 lyso-paf C-16 73.48 µM -0.474890198651435 0.338284173333456 no 2220 0.317432618927203 3224 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.475261508850492 0.33815106288346 no 2221 0.317300295284783 3216 688803 SGTC_870 0573-2213 57.6 µM -0.47528862737556 0.338141341995566 no 2222 0.317290631983401 3340 3916321 SGTC_2284 7945075 39.21 µM -0.47611588486751 0.337844855723171 no 2223 0.316995910398794 3338 1245402 SGTC_651 3253-0966 34.4 µM -0.476718727748508 0.337628862226784 no 2224 0.316781212626099 3253 781462 SGTC_796 1234-0020 70.7 µM -0.476786790707895 0.337604479203402 no 2225 0.316756976410664 3293 46495034 SGTC_2929 9013348 24.6 µM -0.478559498149212 0.336969660973709 no 2226 0.316126018704243 3288 2995952 SGTC_1956 st077085 54 µM -0.480199780588001 0.336382678293601 no 2227 0.315542671424616 3266 24208685 SGTC_3198 9112019 49.47 µM -0.480283191937407 0.336352839792965 no 2228 0.315513019414791 3303 45595555 SGTC_2841 9004761 38.96 µM -0.480305728864096 0.336344777900262 no 2229 0.315505007937038 3246 2991039 SGTC_3143 9086658 49.47 µM -0.4805439939567 0.336259550491771 no 2230 0.315420314227653 3281 25236626 SGTC_22 0964-0034 14.468 µM -0.483990283408229 0.335027755942158 no 2231 0.314196382479216 3300 138402 SGTC_159 3970-0959 50 µM -0.48588009234592 0.334353039991441 no 2232 0.313526091914847 3418 6615653 SGTC_3203 9113543 49.47 µM -0.489694964304257 0.332992652487745 no 2233 0.312174882884385 3356 17018012 SGTC_1992 st073643 23.3 µM -0.491464050567703 0.332362538230845 no 2234 0.311549136158402 3278 3161292 SGTC_341 1486-1430 230 µM -0.491563080565257 0.332327279643087 no 2235 0.311514124136559 3216 2054753 YPL210C SRP72 SGTC_2297 7971671 152.32 µM -0.495381130674179 0.33096903712538 no 2236 0.310165555855142 3395 909016 SGTC_1104 tacrolimus 29.8 µM -0.495709458715515 0.330852340395631 no 2237 0.310049706332721 3369 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1478 0453-0656 35.7 µM -0.495908625146223 0.33078155922855 no 2238 0.309979440267188 3367 5258496 SGTC_3103 9120822 49.47 µM -0.496618946974585 0.330529169339154 no 2239 0.30972889472103 3474 17141819 SGTC_2446 5162541 200 µM -0.497894742746493 0.330076050107769 no 2240 0.309279116495738 3248 1549321 SGTC_2995 9067767 71.4286 µM -0.498253024806711 0.329948845295665 no 2241 0.309152856502446 3281 11673567 SGTC_2472 5377652 49.4 µM -0.499708580849381 0.32943226556931 no 2242 0.308640144778183 3321 1610903 SGTC_1665 st014639 11.4 µM -0.501659038893337 0.32874055435232 no 2243 0.30795369111373 3384 981133 YIL048W NEO1 SGTC_1026 k007-1105 30.6 µM -0.502529143543801 0.328432169056199 no 2244 0.307647678691304 3368 7066794 SGTC_385 1494-0393 12.4 µM -0.50362518090388 0.328043874270044 no 2245 0.307262397024678 3303 3090647 SGTC_641 4092-0595 30 µM -0.504482080123205 0.327740428673927 no 2246 0.306961325841009 3375 786260 SGTC_858 0438-0351 2.77 µM -0.50458419324878 0.327704275900234 no 2247 0.306925457110609 3317 2799119 SGTC_1210 3013-0140 750 nM -0.505766032932991 0.327285967531525 no 2248 0.306510453162451 3387 905973 SGTC_2340 7987427 183.45 µM -0.5058609467628 0.327252382484092 no 2249 0.306477134847357 3361 2239331 SGTC_2904 7225135 42.03 µM -0.506325052192795 0.327088179952739 no 2250 0.306314239468979 3406 4446116 SGTC_2156 5649887 115 µM -0.506912338384331 0.326880443498722 no 2251 0.30610816400012 3395 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_703 3875-0075 71.8 µM -0.508572229761709 0.326293592486507 no 2252 0.30552604918101 3337 2850814 SGTC_3112 9123419 49.47 µM -0.509127773526966 0.326097277110549 no 2253 0.30533133267479 3389 17015854 SGTC_1875 nocodazole 6 µM -0.509451547887633 0.325982885510143 no 2254 0.305217876079912 3411 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1386 3228-0095 33.8 µM -0.510089923104058 0.325757391350974 no 2255 0.304994232286794 3394 870181 SGTC_3263 9137018 49.47 µM -0.511442814934447 0.325279718235606 no 2256 0.304520510621327 3332 43844957 SGTC_1204 4049-0315 18.3 µM -0.511561648251416 0.325237774786365 no 2257 0.304478916201755 3459 588402 SGTC_990 3985-0011 41.3 µM -0.512549376183786 0.324889231711226 no 2258 0.304133286387697 3304 5399565 YGL099W LSG1 SGTC_1325 1431-0015 227 µM -0.515242041174453 0.323939840354247 no 2259 0.303191947199389 3271 1103340 SGTC_2337 9009472 200 µM -0.515468140715224 0.323860173195805 no 2260 0.303112963509145 3482 5742383 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.516827302542177 0.323381436746312 no 2261 0.302638359562316 3309 115019 SGTC_330 1488-0319 80.1 µM -0.520539413082534 0.322075414104593 no 2262 0.301343832496974 3370 6846614 SGTC_2514 salinomycin 42.74 µM -0.521806194747824 0.32163022677244 no 2263 0.300902638044475 3436 23682228 A polyether potassium ionophore. SGTC_7 0192-1582 4.227 µM -0.523183260814262 0.321146572403287 no 2264 0.300423364496783 3382 252616 SGTC_441 propafenone 146 µM -0.523231903031752 0.321129493780327 no 2265 0.300406441385719 3310 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.525832617152506 0.32021691649633 no 2266 0.299502254957805 3365 2333 A French combination drug. SGTC_2292 7671323 168.05 µM -0.52632962667811 0.320042641871912 no 2267 0.299329600891122 3424 937504 SGTC_2231 micatex 6.853 µM -0.526511642045318 0.319978828760056 no 2268 0.299266382627398 3380 20737 An antifungal of unknown mechanism. SGTC_1548 st061468 90.8 µM -0.529519275531056 0.31892514916554 no 2269 0.298222638276584 3379 390799 SGTC_972 1319-0219 195 µM -0.530204247340243 0.318685383549619 no 2270 0.297985163267611 3374 23903702 SGTC_2849 9019321 12.99 µM -0.530703222621448 0.318510771406096 no 2271 0.297812226255782 3400 16489627 SGTC_2452 5863136 48.41 µM -0.531319987364993 0.318294995541732 no 2272 0.297598528544259 3352 2184096 SGTC_2051 5263410 176 µM -0.531592234430746 0.318199769192382 no 2273 0.297504222182563 3466 227584 SGTC_1146 3579-1023 7 µM -0.532649880552113 0.317829940669622 no 2274 0.297137983191599 3431 X1146 SGTC_2726 cimetidine 79.27 µM -0.533072873038465 0.317682083155047 no 2275 0.296991568162485 3373 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3272 9137413 49.47 µM -0.534216547595747 0.317282456006396 no 2276 0.296595860883687 3376 17614870 SGTC_617 3770-0098 35 µM -0.534734438971781 0.317101562429681 no 2277 0.296416751812978 3348 5962639 SGTC_2917 7979103 53.79 µM -0.535588140458875 0.316803469592135 no 2278 0.296121613463384 3441 2980565 SGTC_1286 0929-0070 131 µM -0.536905574833806 0.316343685311282 no 2279 0.295666419993104 3446 1420408 SGTC_2635 hydroquinidine 100 µM -0.537204935716693 0.316239247975558 no 2280 0.295563031145204 3384 442912 An experimental heart treatment. SGTC_3276 9139060 49.47 µM -0.538333968803641 0.315845496765605 no 2281 0.295173251991066 3430 4870619 SGTC_707 0865-0008 204 µM -0.53865439389314 0.315733786286695 no 2282 0.295062673898543 3375 723043 SGTC_1305 1181-0477 144 µM -0.539016876228895 0.315607433590841 no 2283 0.294937604935907 3455 6252086 SGTC_1206 3978-0017 132 µM -0.539890225378856 0.315303093448704 no 2284 0.294636369603025 3515 3873677 SGTC_79 0052-0007 94.094 µM -0.541210794203818 0.3148431465199 no 2285 0.294181149138369 3480 2801472 SGTC_2993 9054257 71.4286 µM -0.541463076339623 0.314755310662185 no 2286 0.294094220574714 3395 6470217 YGL055W OLE1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.543192532425567 0.314153456629691 no 2287 0.293498623796198 3478 23847180 SGTC_2842 9000675 19.48 µM -0.546093175146676 0.313145136707129 no 2288 0.292500945455438 3362 2989072 SGTC_2586 curcumin 80 µM -0.546192421886243 0.313110661258449 no 2289 0.292466837366902 3420 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2293 7624732 200 µM -0.547284100366825 0.312731551581565 no 2290 0.292091782716356 3402 894453 SGTC_3012 9080433 71.4286 µM -0.547437485963967 0.312678300871814 no 2291 0.292039103840327 3460 17688859 SGTC_2569 tetrandrine 100 µM -0.547526120517119 0.312647531493388 no 2292 0.292008665132686 3340 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_898 1000-0849 28.3 µM -0.547693343857087 0.312589483667839 no 2293 0.291951241637659 3409 6751807 SGTC_1644 st010134 20.9 µM -0.54846341369153 0.312322231239368 no 2294 0.291686872149851 3439 3818134 SGTC_3247 9135149 49.47 µM -0.549073849361224 0.312110449907799 no 2295 0.291477385321548 3395 8934436 YOR116C RPO31 SGTC_696 1560-0013 611 µM -0.549362101387919 0.312010466844295 no 2296 0.291378488563074 3513 1650269 SGTC_1436 4092-1007 8.32 µM -0.550755027928299 0.311527511765732 no 2297 0.290900808379905 3378 2881121 SGTC_914 3820-6779 408 µM -0.552310678566881 0.310988520119603 no 2298 0.290367757805103 3363 2893481 SGTC_2869 9037858 32.47 µM -0.552656246490107 0.3108688449695 no 2299 0.29024940953808 3418 27187042 SGTC_2171 5739187 198.077 µM -0.552789014265199 0.310822870894435 no 2300 0.290203945944554 3308 2262761 SGTC_832 4083-0019 164 µM -0.55362090259654 0.310534876547181 no 2301 0.289919158868797 3477 1990758 SGTC_482 fipronil 114 µM -0.553962647441928 0.31041660032788 no 2302 0.289802204576904 3455 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_688 0527-0193 473 µM -0.556098129060924 0.309677964888847 no 2303 0.289071887017622 3363 4007154 SGTC_3285 9112818 20.8695 µM -0.556802326283648 0.309434560404783 no 2304 0.288831247150775 3452 17017947 YPR165W RHO1 SGTC_1311 1190-0148 100 µM -0.557201938801546 0.309296472232821 no 2305 0.288694732608368 3479 1961333 SGTC_1711 st032263 62.8 µM -0.557852790629442 0.309071624673778 no 2306 0.288472455445887 3403 3958979 SGTC_177 1327-0068 8.361 µM -0.558975131261812 0.308684061492823 no 2307 0.288089346275513 3445 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2979 9012552 45.46 µM -0.559403275282858 0.308536272230449 no 2308 0.287943263295608 3505 17100905 SGTC_680 0417-1641 114 µM -0.559514834831817 0.308497768544021 no 2309 0.28790520485957 3356 2835990 SGTC_143 4032-1194 15.74 µM -0.561129240102132 0.307940808289295 no 2310 0.287354718094831 3448 1806963 SGTC_1985 st071382 65.5 µM -0.561192162463797 0.307919109391204 no 2311 0.287333272646749 3474 6123237 SGTC_2074 5212007 75.395 µM -0.561322372754115 0.307874208253799 no 2312 0.287288896265793 3434 758611 SGTC_1702 st027038 51 µM -0.561977216406221 0.307648438503195 no 2313 0.287065771139901 3449 5521182 SGTC_2330 7979373 200 µM -0.562511395534578 0.307464324061527 no 2314 0.286883820879007 3385 1863007 SGTC_131 0141-0277 33.849 µM -0.563279614817115 0.307199628505693 no 2315 0.286622248509814 3456 1547771 SGTC_1097 itavastatin 7.23 µM -0.563604310482843 0.307087782429495 no 2316 0.286511726313585 3467 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1534 6-azauridine 81.6 µM -0.563646945249837 0.307073097605674 no 2317 0.286497215493417 3420 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2791 5663188 71.43 µM -0.564778502742812 0.306683464935209 no 2318 0.286112215350099 3472 54690634 SGTC_333 3486-0131 40.1 µM -0.565047276267231 0.30659094939683 no 2319 0.286020804216147 3532 6744690 SGTC_2591 skatole 100 µM -0.565169413409086 0.306548912187142 no 2320 0.285979269389458 3470 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3020 9089140 49.47 µM -0.56575322493787 0.306348010870974 no 2321 0.285780773893109 3485 17217859 SGTC_334 1502-1024 68.5 µM -0.568554287268432 0.305384919211966 no 2322 0.284829327275757 3485 3296216 SGTC_3341 9147222 25.867 µM -0.572528871259194 0.304020644408638 no 2323 0.283481866031431 3480 1939759 SGTC_1082 camptothecin 424.86 nM -0.573099400229359 0.303825033690951 no 2324 0.283288696657546 3339 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3163 9099914 49.47 µM -0.573737883407013 0.303606190895729 no 2325 0.283072594269423 3487 16268368 SGTC_2806 7952793 58.44 µM -0.574346647187175 0.303397600114332 no 2326 0.282866624479696 3471 2972490 SGTC_1435 4092-0789 56.7 µM -0.574962750048441 0.303186559844278 no 2327 0.282658244887898 3486 2248285 SGTC_759 3486-0358 89.3 µM -0.575084171163053 0.303144975922156 no 2328 0.282617186289904 3528 875103 SGTC_3078 9116413 49.47 µM -0.576231837692135 0.302752052762585 no 2329 0.282229244068022 3405 17177322 SGTC_1658 st012944 20 µM -0.577497364288301 0.302319042858679 no 2330 0.281801759309814 3460 24207260 SGTC_3026 9090633 49.47 µM -0.577509410321563 0.302314922548573 no 2331 0.281797691755954 3430 25236842 SGTC_1940 st075990 51.1 µM -0.580958373543331 0.301136252731529 no 2332 0.280634254404836 3600 1084979 SGTC_684 1140-0066 328 µM -0.583162783372817 0.300383990587964 no 2333 0.279891861090878 3499 6813534 SGTC_1785 bathophenanthroline 24 µM -0.58382472966464 0.300158265102835 no 2334 0.27966911925921 3398 72812 An iron chelator. SGTC_3122 9126309 49.47 µM -0.583852479831901 0.300148803895776 no 2335 0.279659783336874 3506 17591206 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.586444765959138 0.29926557922386 no 2336 0.278788334403322 3514 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2784 7567673 72.73 µM -0.586743168489228 0.299163985429013 no 2337 0.278688105302854 3530 3471247 SGTC_2216 7189485 200 µM -0.586981086854648 0.299082995222909 no 2338 0.278608204532101 3499 731273 SGTC_273 hydroxyurea 18.1 mM -0.587569679988416 0.298882673993408 no 2339 0.278410583653687 3525 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2053 5265679 138 µM -0.588751035019013 0.298480796808218 no 2340 0.278014148486341 3452 764595 SGTC_1718 roemerine 11.9335 µM -0.588967387055684 0.298407224114606 no 2341 0.277941575645356 3493 235224 An aporphine alkaloid with mutagenic activity. SGTC_1607 st000305 50.6 µM -0.589036613528191 0.298383684696972 no 2342 0.277918356361627 3500 5457690 SGTC_1591 genipin 88.4 µM -0.58935082522533 0.2982768523747 no 2343 0.277812978370857 3508 442424 A DNA cross-linking agent. SGTC_659 k018-0002 107 µM -0.591458580977588 0.297560663803047 no 2344 0.277106599650061 3515 6797879 YHR007C ERG11 SGTC_580 1123-0028 41 µM -0.592552535517478 0.297189261687668 no 2345 0.276740326058529 3554 1677248 YPR107C YTH1 SGTC_2044 5102272 200 µM -0.594044020944046 0.296683237868543 no 2346 0.276241335179955 3505 592666 SGTC_1847 st056231 15 µM -0.594560574199204 0.296508076262523 no 2347 0.276068620283073 3521 5393180 SGTC_2691 st077356 60.2 µM -0.595575359965695 0.296164103622927 no 2348 0.275729470686435 3552 2839272 SGTC_384 k007-0144 5.16 µM -0.595575516221558 0.296164050672407 no 2349 0.275729418480237 3490 6824886 SGTC_2259 7964009 200 µM -0.595929917010866 0.296043965838895 no 2350 0.275611023152542 3530 313134 SGTC_303 1348-1668 34.2 µM -0.596231485940945 0.29594180010617 no 2351 0.275510297150747 3491 5380509 SGTC_2680 butyl paraben 22.24 µM -0.596400588566295 0.295884518485589 no 2352 0.27545382368816 3528 7184 An antifungal and steroid mimetic. SGTC_2821 7996764 71.43 µM -0.596832597517895 0.29573820341641 no 2353 0.275309575969286 3603 2987135 SGTC_1217 1183-1422 255 µM -0.597324542490992 0.295571629395287 no 2354 0.275145360908032 3527 2849664 SGTC_1277 0873-0036 22 µM -0.600766141065721 0.29440750233974 no 2355 0.273997879391733 3541 5965735 SGTC_2795 7780010 54.55 µM -0.601254146487673 0.294242605106356 no 2356 0.273835362591846 3497 953673 SGTC_1247 0448-0043 5.84 µM -0.601700191604768 0.294091923606793 no 2357 0.273686861223096 3507 3089013 YGL099W LSG1 SGTC_1745 st081495 74 µM -0.602036772147857 0.293978244685514 no 2358 0.27357483016863 3510 13842402 YBL026W LSM2 SGTC_1224 0823-0416 294 µM -0.603212349279495 0.29358135704667 no 2359 0.273183716695149 3542 3598164 SGTC_1733 st037357 54.9 µM -0.603520816618428 0.293477256219456 no 2360 0.273081135789077 3485 1272339 YGL099W LSG1 SGTC_2987 9018338 71.43 µM -0.604303821280589 0.293213086472434 no 2361 0.272820833122478 3566 5055682 SGTC_2367 9070478 135.38 µM -0.604887399216267 0.293016270950696 no 2362 0.272626908111984 3507 572802 SGTC_1179 1021-1431 9.29 µM -0.60565680971672 0.292756875880969 no 2363 0.272371334895863 3486 2840958 SGTC_2100 5377183 190 µM -0.605820945129265 0.2927015539213 no 2364 0.272316829841081 3537 2844202 SGTC_1998 st075797 76.8 µM -0.607522837858522 0.292128216138794 no 2365 0.27175199561698 3538 24208315 SGTC_2271 7849410 118.62 µM -0.610138378484776 0.291248106692902 no 2366 0.270885072731918 3536 972430 SGTC_2399 5884133 200 µM -0.611264773888137 0.290869464924215 no 2367 0.270512153771912 3517 722445 SGTC_2480 5767542 37.17 µM -0.611991787087445 0.290625199130821 no 2368 0.270271595703406 3537 2867358 SGTC_1320 1313-0481 95.3 µM -0.61279626167687 0.290355019342047 no 2369 0.270005531509597 3574 6813365 YLR208W SEC13 SGTC_1850 st056238 17 µM -0.613255419819497 0.290200865532688 no 2370 0.269853732732542 3546 5393177 SGTC_37 0566-0070 1.56 µM -0.61504745305177 0.289599590853686 no 2371 0.269261691354266 3531 1626686 SGTC_2326 6164455 177.58 µM -0.615855562488627 0.28932864017744 no 2372 0.268994926210037 3501 2888790 SGTC_2690 usnic acid 100 µM -0.616174389886893 0.289221773452254 no 2373 0.268889714550758 3622 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_902 1120-0002 2.07 µM -0.618470285735707 0.288452767995888 no 2374 0.268132689541002 3554 3280475 SGTC_376 3970-0862 59.1 µM -0.618916177365552 0.288303529369147 no 2375 0.267985790325269 3537 3135186 SGTC_2596 sinensetin 100 µM -0.621649202054201 0.287389590475199 no 2376 0.267086280310389 3483 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3138 9097216 49.47 µM -0.621967951397006 0.287283088197985 no 2377 0.266981470901657 3574 25237486 SGTC_1994 st072947 40.9 µM -0.623537984297806 0.28675877294758 no 2378 0.26646552463355 3578 5286565 YDL195W SEC31 SGTC_863 0466-0191 129 µM -0.624854373123665 0.286319512499818 no 2379 0.266033320280186 3552 765160 YPR165W RHO1 SGTC_1892 st058411 7.36 µM -0.626575285367883 0.285745750509746 no 2380 0.265468836487818 3531 3934738 SGTC_1491 4138-0063 26.5 µM -0.626825568121052 0.285662350383635 no 2381 0.265386790817756 3540 23883227 SGTC_2838 9002687 71.43 µM -0.628064736283387 0.285249600995634 no 2382 0.264980766393868 3529 6457060 SGTC_3099 9120367 49.47 µM -0.628386714842336 0.285142401018396 no 2383 0.264875318952862 3586 24824940 SGTC_1468 k284-1086 134 µM -0.629065629243934 0.284916425291197 no 2384 0.264653045540858 3588 15996457 SGTC_1108 betulinic acid 729.144 nM -0.629291165188715 0.284841374868236 no 2385 0.264579227121567 3564 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2194 5927483 104.545 µM -0.62942608918513 0.284796481421539 no 2386 0.264535071203797 3570 760979 SGTC_2464 5717415 7.67 µM -0.629489956363634 0.284775231984935 no 2387 0.264514171011568 3465 5285744 SGTC_2553 4-methylesculetin 85.09 µM -0.630295773078405 0.284507191356237 no 2388 0.264250544003586 3547 5319502 SGTC_2504 purpurogallin 52.29 µM -0.631122470231767 0.284232330512693 no 2389 0.263980224966451 3506 5281571 An antioxidant. SGTC_68 0986-0284 82.829 µM -0.631723366631655 0.284032623768352 no 2390 0.263783828275569 3536 423278 YIL048W NEO1 SGTC_2777 climbazole 1.536 µM -0.633666701026558 0.283387220388421 no 2391 0.263149180344133 3540 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.634711249988942 0.283040604611054 no 2392 0.262808377524813 3602 364106 SGTC_465 cgp-37157 41 µM -0.634719610537108 0.283037831126663 no 2393 0.262805650657017 3488 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3211 9128781 49.47 µM -0.634910684642468 0.282974448761342 no 2394 0.262743334067853 3513 17194361 SGTC_3014 9081533 49.47 µM -0.634963181180231 0.282957036005637 no 2395 0.26272621425854 3572 21367265 SGTC_3077 9117319 49.47 µM -0.63524870707238 0.282862337957595 no 2396 0.262633110514366 3573 17154678 SGTC_1728 st035614 33.7865 µM -0.635783128520736 0.282685131664423 no 2397 0.262458892760529 3518 15945546 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.63801912646151 0.281944286740919 no 2398 0.261730614840803 3564 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_32 0928-0142 34.1 µM -0.638799948763439 0.281685800288666 no 2399 0.261476540810992 3560 2244242 SGTC_856 0433-0016 11.3 µM -0.639686765729784 0.281392363595992 no 2400 0.261188130538932 3578 3911780 SGTC_3110 9122132 49.47 µM -0.640706264348268 0.281055206582113 no 2401 0.260856771702143 3649 918317 SGTC_2832 7992762 51.95 µM -0.641270690115939 0.2808686300728 no 2402 0.260673414308515 3437 2985177 SGTC_1888 azatryptophan 97.5 µM -0.641899269432813 0.280660917471889 no 2403 0.260469294312981 3548 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2056 5235370 200 µM -0.644242902510879 0.279887124980185 no 2404 0.259708967222005 3558 5511916 SGTC_3066 9117245 49.47 µM -0.645255361556809 0.279553163797911 no 2405 0.259380857500278 3609 17176980 SGTC_877 0771-0151 33.1 µM -0.645496884250719 0.279473525753628 no 2406 0.259302618383683 3562 6166523 SGTC_237 nikkomycin 200 µM -0.646233297643101 0.279230773860973 no 2407 0.259064139151138 3626 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3104 9120930 49.47 µM -0.647101949140567 0.278944562694547 no 2408 0.258782981950111 3598 17014836 SGTC_2450 5739737 12.93 µM -0.647867004209037 0.278692603673519 no 2409 0.258535486748342 3594 2262825 SGTC_483 fpl-64176 144 µM -0.648657527288586 0.278432373609562 no 2410 0.258279881483193 3608 3423 SGTC_2925 9010536 32.5 µM -0.648700618633413 0.278418191894909 no 2411 0.258265952227453 3591 2994177 SGTC_3109 9122853 49.47 µM -0.650242710552301 0.277910908632712 no 2412 0.257767728189897 3618 1234709 SGTC_1681 tripelennamine 100 µM -0.650267852674277 0.277902641673013 no 2413 0.257759609327 3593 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2355 9061122 103.12 µM -0.651048007207018 0.277646179392122 no 2414 0.257507748767201 3567 5302957 SGTC_518 1021-0119 62.6 µM -0.651499734396327 0.277497734781031 no 2415 0.257361974243661 3522 1097762 SGTC_390 dec-rvkr-cmk 16.7 µM -0.651725689839369 0.277423496849489 no 2416 0.257289073435311 3635 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1349 flufenamic acid 69 µM -0.652028477486271 0.277324030830186 no 2417 0.257191400810537 3571 3371 A non-steroidal anti-inflammatory. SGTC_251 melphalan 456.522 µM -0.653592363078331 0.27681057080589 no 2418 0.256687232857115 3650 460612 A DNA alkylator. SGTC_1455 4262-0120 131 µM -0.653795460618616 0.276743923337145 no 2419 0.256621795719007 3672 1529587 SGTC_657 3534-0529 86.7 µM -0.654554389652426 0.276494946596022 no 2420 0.256377349013893 3630 1049549 SGTC_2352 9027995 87.8 µM -0.655266710880367 0.276261360126355 no 2421 0.256148024862071 3550 2997347 SGTC_2394 5221648 200 µM -0.656912390433154 0.275722074601228 no 2422 0.255618625368502 3655 788586 SGTC_965 1291-5240 308 µM -0.65722014653956 0.275621281071348 no 2423 0.255519686612652 3604 2834598 SGTC_1178 0988-0033 191 µM -0.657693879545971 0.275466163686115 no 2424 0.255367427998365 3604 5392207 SGTC_2896 9052656 71.43 µM -0.659017554102412 0.275032972347168 no 2425 0.254942248170643 3593 6469436 SGTC_215 1287-0124 461.5 µM -0.660148450990994 0.274663136260954 no 2426 0.254579284455254 3605 5560863 SGTC_1873 rapamycin 2 nM -0.660529644337303 0.274538530272017 no 2427 0.254457000682312 3608 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2686 alizarin 95.37 µM -0.661933487305343 0.274079877160453 no 2428 0.254006924635696 3575 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.663402378153602 0.273600377751447 no 2429 0.25353644160501 3615 5379071 SGTC_789 1309-1135 70.6 µM -0.664454431356738 0.273257204625715 no 2430 0.253199752508236 3625 3092424 SGTC_387 norethindrone acetate 66.7 µM -0.664561978089172 0.273222135575554 no 2431 0.253165347526807 3607 541197 SGTC_1910 st062352 60.4 µM -0.667595637345962 0.272233833502495 no 2432 0.252195871633037 3584 2245730 SGTC_1841 st054148 70 µM -0.668412079459387 0.271968157640237 no 2433 0.251935293464353 3580 675442 SGTC_777 1315-0167 517 µM -0.66907116956387 0.271753779312265 no 2434 0.251725039946416 3592 4221767 SGTC_295 k015-0027 31 µM -0.669640248698634 0.271568746001791 no 2435 0.251543575013485 3599 3887424 SGTC_1564 D-Arginine 115 µM -0.669656942170208 0.27156331914812 no 2436 0.251538252931564 3590 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2076 5212012 200 µM -0.670001010731901 0.271451478485172 no 2437 0.251428572937625 3528 604802 SGTC_2889 9059656 51.95 µM -0.673140142484071 0.270432153866685 no 2438 0.250429068843286 3683 3949838 SGTC_455 paf C-16 10 µM -0.673202832795677 0.270411816851631 no 2439 0.250409129627069 3603 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_625 k213-0058 121 µM -0.674959737788451 0.269842180144022 no 2440 0.249850672628965 3696 3655420 SGTC_2610 ononetin 44.17 µM -0.676621438265472 0.269303964734869 no 2441 0.249323086734275 3641 259632 SGTC_1318 1280-3875 124 µM -0.676713662359786 0.269274109646764 no 2442 0.249293823164126 3631 373245 SGTC_1431 4049-0260 9.09 µM -0.677439072367914 0.269039335419261 no 2443 0.249063707452888 3620 3854841 SGTC_1030 k029-0042 36.7 µM -0.677889658910427 0.268893557761087 no 2444 0.248920828594393 3642 6080581 SGTC_998 3996-0085 177 µM -0.678336722253077 0.268748959167468 no 2445 0.248779110050784 3671 715391 SGTC_3102 9121669 49.47 µM -0.679506213961878 0.268370882490417 no 2446 0.248408585853423 3655 41905072 SGTC_1619 st003326 88.7 µM -0.679788342963461 0.26827971507261 no 2447 0.24831924439214 3614 2849032 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.679801810682897 0.268275363491357 no 2448 0.248314980013583 3654 5106787 A p450 inhibitor. SGTC_1905 st060207 84.5 µM -0.679804318652483 0.268274553140305 no 2449 0.248314185901878 3587 1948547 SGTC_2110 5483698 200 µM -0.680200079375962 0.268146694166019 no 2450 0.248188891051471 3653 2848765 YHR062C RPP1 SGTC_1113 artemisinin 1.17947 µM -0.680359879393877 0.268095076042097 no 2451 0.248138309132164 3659 2240 An anti-malaria and mitochondrial poison. SGTC_741 4582-0002 126 µM -0.680902864330836 0.267919720050078 no 2452 0.247966477776213 3624 2912688 SGTC_1934 st074720 32.6 µM -0.686485835674178 0.266120066560989 no 2453 0.246203396635648 3648 17250992 SGTC_1022 4477-0945 21.3 µM -0.68662280563933 0.266075991771153 no 2454 0.246160226682767 3638 4648966 SGTC_1147 3809-1045 12.3 µM -0.687802268827278 0.265696612032109 no 2455 0.24578865359229 3614 325925 SGTC_1743 st037606 46.3785 µM -0.688564428921782 0.265451605704884 no 2456 0.24554870614623 3681 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3067 9117431 49.47 µM -0.689622180888861 0.265111767555976 no 2457 0.245215907447071 3667 17150885 SGTC_1629 st005085 44.9 µM -0.690192598565068 0.26492859358569 no 2458 0.24503653861249 3658 24207091 SGTC_1188 1403-0014 4.57 µM -0.690270451538746 0.264903598230581 no 2459 0.245012063083965 3691 9614867 SGTC_3233 9132340 49.47 µM -0.691563007366386 0.264488787470138 no 2460 0.24460589979599 3642 17682950 SGTC_2432 5630864 12.22 µM -0.691863684126306 0.264392340823225 no 2461 0.244511469345593 3638 5714970 SGTC_1679 SEC14.276 6.7 µM -0.692089490974144 0.264319921612346 no 2462 0.244440565430986 3692 1005053 YMR079W SEC14 SGTC_2892 9047358 58.44 µM -0.693383613666554 0.263905074418005 no 2463 0.244034421440946 3654 6466771 SGTC_2731 amoxapine 43.43 µM -0.693737339438788 0.263791740989182 no 2464 0.243923472472153 3705 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1074 carmofur 3.8 µM -0.695086525737512 0.263359690861739 no 2465 0.243500539203412 3699 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_674 0498-0004 451 µM -0.695566713773448 0.263206007403216 no 2466 0.243350108930114 3646 4231473 SGTC_1724 st037281 8.293 µM -0.695919496069778 0.263093129158908 no 2467 0.243239623531554 3689 574124 YDL195W SEC31 SGTC_2095 5432005 200 µM -0.696446905307298 0.262924422424602 no 2468 0.243074498537747 3679 783734 SGTC_3070 9117005 49.47 µM -0.698999116800654 0.262108807666299 no 2469 0.242276291394284 3708 8779016 SGTC_1783 st039459 87.517 µM -0.699388487639146 0.261984489833966 no 2470 0.242154640225267 3730 729761 SGTC_2779 methotrexate 400 µM -0.699601118016113 0.261916614237859 no 2471 0.242088222078413 3729 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1447 4239-0816 81.9 µM -0.702123635604768 0.261112068028486 no 2472 0.241301031780232 3675 1341554 SGTC_711 k292-0785 179 µM -0.703674699488834 0.260617994269883 no 2473 0.240817689939797 3695 4146315 SGTC_2833 9001315 45.46 µM -0.7039727909173 0.260523095795507 no 2474 0.240724859204976 3680 2989378 SGTC_2267 7931562 200 µM -0.704443818896106 0.260373178628525 no 2475 0.240578212798796 3614 934880 SGTC_2956 9076196 2.52 µM -0.705038931692417 0.260183831733329 no 2476 0.240393004298783 3722 16423868 SGTC_76 0433-0009 400.328 µM -0.70562693987899 0.259996815037838 no 2477 0.240210083172695 3719 2841569 SGTC_200 k038-0079 37.545 µM -0.706578527922963 0.259694308275906 no 2478 0.239914218214863 3647 3436683 SGTC_2695 st077686 51.995 µM -0.706590838512589 0.259690395969912 no 2479 0.239910391945213 3695 2876092 SGTC_1778 st046819 58.9 µM -0.70762889650986 0.259360610555817 no 2480 0.239587871607088 3731 671715 SGTC_447 ml7 120 µM -0.708531144741215 0.259074147033287 no 2481 0.23930773917157 3713 4216 Selective myosin light chain kinase inhibitor. SGTC_1366 1683-0113 21.9 µM -0.708774848905451 0.258996799112668 no 2482 0.239232103956795 3708 708623 SGTC_2511 berberine 10.47 µM -0.710390206848335 0.25848441168029 no 2483 0.238731097204594 3694 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1968 st069590 43.6 µM -0.711973993662619 0.257982548776181 no 2484 0.238240440159299 3656 6384066 SGTC_2922 7999257 32.47 µM -0.71226094376242 0.25789167549457 no 2485 0.238151602188932 3675 2988377 SGTC_1061 3448-9325 110 µM -0.712592845645388 0.257786587299748 no 2486 0.238048870069675 3643 723482 SGTC_634 1611-4317 11.2 µM -0.713225530768646 0.257586325410348 no 2487 0.237853105146853 3717 2843522 SGTC_1145 3546-0597 10.2 µM -0.715282758437805 0.256935716312476 no 2488 0.23721717008597 3673 875334 SGTC_1865 st057639 52.2 µM -0.718145466742525 0.256031794463944 no 2489 0.236333799186982 3700 688818 SGTC_2868 9035608 32.47 µM -0.719553202857995 0.255587900343873 no 2490 0.235900066964415 3699 6462614 SGTC_3015 9080845 49.47 µM -0.720249147492349 0.255368600313606 no 2491 0.235685804289564 3755 5296973 SGTC_2180 6301957 200 µM -0.720430019056605 0.255311621741716 no 2492 0.235630136366241 3669 845462 SGTC_3279 9140807 49.47 µM -0.722562854024162 0.25464023276419 no 2493 0.234974248285094 3744 45595718 SGTC_721 1187-1332 279 µM -0.723051409472015 0.25448657206876 no 2494 0.234824150143328 3640 25730 SGTC_375 3970-0961 9.27 µM -0.724313962724733 0.25408969833473 no 2495 0.234436503403432 3694 2898222 SGTC_681 1642-0006 26.6 µM -0.724331723010377 0.254084117844478 no 2496 0.234431052918967 3723 4446530 SGTC_1936 st074407 74.3 µM -0.724983266099981 0.25387943980692 no 2497 0.234231148219637 3765 809813 SGTC_3189 9110682 49.47 µM -0.725360861732798 0.253760860208696 no 2498 0.234115338549207 3774 17122418 SGTC_1670 st016595 4.04 µM -0.725495267903394 0.253718658503891 no 2499 0.234074123442078 3727 597879 SGTC_1090 efavirenz 20.7 µM -0.72584664636782 0.253608347871358 no 2500 0.233966393648139 3769 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1356 1502-0781 85.8 µM -0.725888698959934 0.253595147703054 no 2501 0.233953502504245 3701 567702 SGTC_2405 ticlatone 3.52 µM -0.726677390633288 0.253347646893156 no 2502 0.233711803447072 3643 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1801 st050089 28.441 µM -0.728396382640929 0.252808647079036 no 2503 0.23318548849377 3742 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_127 0180-0333 59.125 µM -0.730964303824241 0.252004586591647 no 2504 0.232400478373973 3667 771601 SGTC_1955 wogonin 32.4 µM -0.731801054483072 0.25174287729229 no 2505 0.232145002681251 3756 5281703 A flavanone. SGTC_957 1187-1561 14.1 µM -0.731911290056733 0.251708409772814 no 2506 0.232111357346949 3711 1538454 SGTC_3328 9140624 29.0385 µM -0.732305948230436 0.251585031854929 no 2507 0.231990924783616 3724 4904392 SGTC_762 1165-0429 115 µM -0.732387326410783 0.251559595406607 no 2508 0.231966096018855 3694 5967793 SGTC_265 mycophenolic acid 32.932 µM -0.732532800778272 0.251514127743171 no 2509 0.231921714972401 3809 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2270 7924575 90.91 µM -0.732911875837019 0.251395669148749 no 2510 0.231806089685035 3736 1262135 SGTC_1378 2093-0007 380 nM -0.733185565107314 0.251310161291957 no 2511 0.231722629084977 3761 3618014 SGTC_2753 fluvastatin 17.09 µM -0.734533140559492 0.250889366978771 no 2512 0.231311934862886 3747 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2242 6630449 61.2675 µM -0.735054346801815 0.250726715036187 no 2513 0.231153198241305 3793 691249 YDR170C SEC7 SGTC_1043 0916-0009 19.3 µM -0.735097264543057 0.250713324258705 no 2514 0.231140130083937 3746 3101130 SGTC_950 1165-0508 94.1 µM -0.735311214467487 0.250646575328302 no 2515 0.23107498995243 3751 6148369 SGTC_1879 gemcitabine 100 µM -0.736626240892847 0.250236515079776 no 2516 0.230674836346008 3731 60750 A nucleoside analog which inhibits DNA replication. SGTC_590 k048-0076 22.4 µM -0.736708833080995 0.250210772515206 no 2517 0.230649717031859 3718 6832814 SGTC_2311 7694451 200 µM -0.739445187879696 0.249358692421402 no 2518 0.229818355766323 3704 2163142 SGTC_2109 5483026 200 µM -0.739494777293534 0.249343264897595 no 2519 0.229803304969732 3746 759335 SGTC_2086 5274770 176.623 µM -0.739805327858867 0.249246662545927 no 2520 0.229709062860206 3774 689278 SGTC_1 0258-0098 57.368 µM -0.741984258740987 0.248569426869566 no 2521 0.229048436480813 3675 6790032 YDR047W HEM12 SGTC_469 w7 172 µM -0.74256933811238 0.248387744869112 no 2522 0.228871228946977 3782 45115570 A P450 inhibitor. SGTC_2528 xanthyletin 44.79 µM -0.743915823189134 0.24796989609347 no 2523 0.228463701006736 3800 65188 An natural product with antifungal activity of unknown mechanism. SGTC_948 3448-0295 75.3 µM -0.745734739279121 0.247406036027059 no 2524 0.227913834736663 3759 678569 SGTC_1945 st075991 56.6 µM -0.7482124375732 0.246639058750434 no 2525 0.227166015053368 3719 1084980 SGTC_140 0062-0056 502.533 µM -0.748538600513743 0.246538189190396 no 2526 0.227067675572776 3731 3758964 SGTC_2728 chlorpromazine 9.18 µM -0.749316575352578 0.246297680970666 no 2527 0.226833209857763 3762 2726 A thorazine and dopamine antagonist. SGTC_2709 st078560 56 µM -0.749553485970453 0.246224465867263 no 2528 0.226761836977895 3743 17250903 SGTC_394 menadione 8.33 µM -0.750220939804573 0.246018258009043 no 2529 0.226560824644136 3707 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_533 1222-0222 6.71 µM -0.751159738567825 0.245728375826978 no 2530 0.226278263602255 3848 3982874 SGTC_532 1548-0774 215 µM -0.753922507573341 0.244876353379654 no 2531 0.225447877333513 3846 5932993 SGTC_2159 5658611 73.75 µM -0.754111391227213 0.244818160841886 no 2532 0.22539116895757 3749 793844 SGTC_1899 st063254 59.6 µM -0.755675043028038 0.244336706547484 no 2533 0.224922025406377 3699 3093813 SGTC_929 2805-0021 398 µM -0.757572531811005 0.24375314861581 no 2534 0.224353464625136 3842 3098024 SGTC_1205 4161-2785 76 µM -0.758226004935547 0.243552352340608 no 2535 0.224157847908851 3836 3498106 SGTC_3062 9077494 49.47 µM -0.758724938790115 0.243399102361903 no 2536 0.224008557647652 3742 16459633 SGTC_26 0302-0163 425.158 µM -0.760445939622006 0.242870888585822 no 2537 0.22349403597688 3804 3100915 SGTC_2371 9071574 200 µM -0.761888016523794 0.242428760892419 no 2538 0.223063421376047 3741 45596039 SGTC_905 2-aminofluorene 215 µM -0.763784157813718 0.241848085388102 no 2539 0.222497939550526 3792 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3250 9135583 49.47 µM -0.763999213635938 0.241782274241093 no 2540 0.222433855606785 3807 7699353 SGTC_3074 9116018 49.47 µM -0.764761035290475 0.241549220626405 no 2541 0.222206927002706 3821 17027303 SGTC_2203 7227154 166.4 µM -0.765211475818085 0.241411480961955 no 2542 0.222072813626696 3773 896304 SGTC_1854 st056233 32.9 µM -0.765786282894826 0.241235773383026 no 2543 0.221901738694631 3699 5393174 SGTC_2816 7982706 58.44 µM -0.76703361941347 0.240854725533617 no 2544 0.221530763534963 3816 2981853 SGTC_1321 1326-2144 215 µM -0.767307691938706 0.240771043235069 no 2545 0.221449298099948 3785 3513030 SGTC_1018 4259-0013 28.1 µM -0.767637335520407 0.240670414441541 no 2546 0.221351337392819 3869 6801262 SGTC_2245 6637752 200 µM -0.767873773241602 0.240598252276628 no 2547 0.221281090083349 3830 681890 SGTC_927 2425-1185 123 µM -0.767965822103296 0.240570161615702 no 2548 0.221253745168024 3759 730375 SGTC_2732 terfenadine 20 µM -0.768840254403539 0.24030339914051 no 2549 0.220994074357558 3773 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1477 0139-0234 16 µM -0.77053967917667 0.239785418063893 no 2550 0.220489913590584 3797 620880 SGTC_3085 9117376 49.47 µM -0.771837513905782 0.239390251393447 no 2551 0.220105335034784 3887 16480349 SGTC_144 4161-2749 112.381 µM -0.772238311418202 0.239268287884222 no 2552 0.219986647232197 3710 797501 YMR168C CEP3 SGTC_1417 3966-0327 90.4 µM -0.773175009039418 0.238983381295633 no 2553 0.219709407059113 3847 651118 SGTC_1449 4112-4002 201 µM -0.773301263813872 0.238944993747631 no 2554 0.219672054002562 3810 2059539 SGTC_1230 0170-0365 3.77 µM -0.774417172870716 0.238605850151825 no 2555 0.219342065751688 3872 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1295 1013-0063 9.78 µM -0.775335397270557 0.238326983953701 no 2556 0.219070749090771 3785 6826038 SGTC_223 busulfan 5 mM -0.775920083897673 0.238149506766746 no 2557 0.218898086682856 3798 2478 A DNA alkylator. SGTC_3308 9128332 17.569 µM -0.776172372981785 0.238072948702687 no 2558 0.218823607982697 3782 17332805 YDL196W YDL196W SGTC_1181 1222-0449 220 µM -0.776364904885621 0.238014533253791 no 2559 0.218766780114624 3808 658318 SGTC_1490 4089-0339 670 nM -0.776925936478108 0.237844357382919 no 2560 0.218601234027949 3743 742542 SGTC_1651 st011928 86.1 µM -0.778416142785685 0.237392662170164 no 2561 0.218161862588834 3799 720198 SGTC_2 0422-0095 29 µM -0.778433926478424 0.237387274614992 no 2562 0.218156622331542 3665 6790840 SGTC_2092 5303694 80.6725 µM -0.778634707586117 0.237326452800464 no 2563 0.218097463911975 3794 1963699 SGTC_3331 9141060 1.957 µM -0.778879738768731 0.237252238084291 no 2564 0.218025280119632 3779 4906567 YPR165W RHO1 SGTC_1233 0325-0408 14.2 µM -0.780052069835245 0.236897340469886 no 2565 0.217680113482519 3853 12874 SGTC_2881 9058953 51.95 µM -0.780240621177398 0.236840287928765 no 2566 0.217624628208754 3781 17122249 SGTC_1126 isoteolin 1.0172 µM -0.780637514896405 0.236720219097082 no 2567 0.217507860399197 3773 133323 SGTC_2712 st079126 47.7 µM -0.781254540232853 0.23653362224845 no 2568 0.217326400770304 3794 3152970 SGTC_1308 1187-1617 41.4 µM -0.781822639239723 0.236361892979093 no 2569 0.217159407103338 3797 2882570 SGTC_2877 9040724 71.43 µM -0.78216006133881 0.236259926972999 no 2570 0.217060256405302 3759 6463895 SGTC_520 3584-0023 682 µM -0.782893345327806 0.236038418512801 no 2571 0.216844872832511 3828 1340790 SGTC_2905 7799065 20.05 µM -0.784410339663109 0.23558053238587 no 2572 0.216399686655549 3711 1296806 SGTC_98 0074-0023 107.663 µM -0.786773941065103 0.234868085849769 no 2573 0.215707105360455 3760 3563821 SGTC_740 k014-0057 261 µM -0.786859026529275 0.234842461260586 no 2574 0.215682197645593 3820 4012779 SGTC_908 3448-7491 47.7 µM -0.788909990858166 0.234225254565528 no 2575 0.215082307968576 3841 1203031 SGTC_829 1635-0120 117 µM -0.789299666084107 0.234108089301971 no 2576 0.214968440878986 3845 285054 SGTC_278 4092-0821 23.9 µM -0.789634040075578 0.234007577568968 no 2577 0.214870761291129 3828 877900 SGTC_2643 anethole 100 µM -0.790820106185218 0.233651242803926 no 2578 0.214524487643726 3821 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_917 harmaline 728.087 nM -0.792024764042312 0.233289630602359 no 2579 0.214173118424092 3838 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_364 0083-0097 67.7 µM -0.792565415234117 0.233127439850352 no 2580 0.214015532630448 3905 5207356 SGTC_356 1634-0012 32.5 µM -0.792692577574475 0.233089301327191 no 2581 0.213978477913959 3779 735457 SGTC_1618 st003135 44.5 µM -0.792830405791595 0.233047967807371 no 2582 0.213938319411656 3734 1270615 SGTC_2734 clemastine 41.6 µM -0.792847570928592 0.233042820412587 no 2583 0.213933318375891 3822 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2565 isoliquiritigenin 100 µM -0.794335491236142 0.23259687036978 no 2584 0.213500073833875 3897 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_406 estrone 100 µM -0.794686482033245 0.232491742831605 no 2585 0.213397948827561 3805 5870 A steroid. SGTC_1250 0485-0349 40.2 µM -0.795288649387684 0.232311445334405 no 2586 0.21322280732198 3829 6842794 YDL195W SEC31 SGTC_562 3772-2733 112 µM -0.795614986459386 0.232213767870067 no 2587 0.213127926606386 3853 2876874 YIL048W NEO1 SGTC_2659 sanguinarine 24.21 µM -0.796072335186315 0.232076915166212 no 2588 0.212994996420018 3767 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3025 9087895 49.47 µM -0.796757949385058 0.231871842592638 no 2589 0.212795810632018 3841 17173641 SGTC_2735 sertaconazole 140 nM -0.796864731109882 0.231839912429194 no 2590 0.212764798015484 3895 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_550 4123-0385 25.7 µM -0.798672813647003 0.231299626638164 no 2591 0.212240077325913 3852 5731123 SGTC_165 k038-0023 64.381 µM -0.8003977518943 0.230784841051231 no 2592 0.211740191553059 3841 46368543 SGTC_2123 5259487 200 µM -0.800929881966185 0.230626162939379 no 2593 0.211586119842938 3830 2173474 SGTC_188 3229-0966 278.469 µM -0.802533293088814 0.230148403783074 no 2594 0.211122268903317 3884 5722370 SGTC_1121 fusaric acid 630.51 nM -0.804644283971375 0.229520249204405 no 2595 0.210512489864975 3850 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1100 amiodarone 5.07 µM -0.804748324404007 0.229489315392047 no 2596 0.210482463585085 3923 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_342 k048-0088 23.3 µM -0.805591753882311 0.229238629053826 no 2597 0.210239140932055 3832 6820570 SGTC_2135 5326629 150.42 µM -0.806060600933676 0.229099343522945 no 2598 0.210103953777521 3806 5020077 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.806639370709176 0.228927467533161 no 2599 0.20993714200164 3843 75037 A free radical scavenger. SGTC_2328 6201408 200 µM -0.806832975695609 0.228869989240537 no 2600 0.209881358967775 3853 2890418 SGTC_3182 9108849 49.47 µM -0.807573604423721 0.228650182928669 no 2601 0.20966804345696 3871 17133045 SGTC_1827 berberine 7.24 µM -0.807609472226568 0.228639540970606 no 2602 0.209657716068326 3781 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2537 larixol 68.93 µM -0.808539143197024 0.228363805143983 no 2603 0.209390141004542 3841 6708759 SGTC_2134 5324836 1.464 µM -0.8092753502129 0.228145582424841 no 2604 0.209178390790819 3821 699272 SGTC_478 N-arachidonylglycine 10 µM -0.810958984436633 0.227646969128498 no 2605 0.208694612619369 3774 5283389 SGTC_254 nsc-64875 3.808 µM -0.811261832545158 0.227557344905162 no 2606 0.208607661787677 3888 56993 SGTC_2093 5331342 194.4 µM -0.811401113439281 0.227516133085631 no 2607 0.208567679969627 3896 33839 SGTC_930 2810-3379 265 µM -0.813346123901573 0.22694106338425 no 2608 0.208009819654267 3870 1015764 SGTC_174 3553-0389 74.3 µM -0.814633687701437 0.226560828438474 no 2609 0.207641010672759 3859 738071 SGTC_1058 3448-5425 97.3 µM -0.814692410796249 0.226543495296613 no 2610 0.207624199283104 3742 7279705 SGTC_2404 5161160 200 µM -0.81842921520435 0.225442053218957 no 2611 0.206556072651846 3825 2831543 SGTC_3192 9110362 49.47 µM -0.819152615101395 0.225229178211558 no 2612 0.20634967299822 3873 16649480 SGTC_698 k064-0052 127 µM -0.819450888523927 0.225141438402833 no 2613 0.206264605556284 3909 5088751 SGTC_475 α-linolenic acid 10 µM -0.819994941917048 0.224981450088392 no 2614 0.206109495326349 3884 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2761 levamisole 97.89 µM -0.820299850977482 0.224891814485286 no 2615 0.206022595662916 3816 26879 An alkaline phosphatase inhibitor. SGTC_109 0132-0036 33.701 µM -0.820826693425159 0.224736983762374 no 2616 0.205872495779152 3676 67274 A color developer. SGTC_2703 st077852 53.4 µM -0.821161137563128 0.224638727257252 no 2617 0.205777244749431 3889 6281836 SGTC_157 1348-1695 65.819 µM -0.821432206154313 0.224559107766605 no 2618 0.205700062519595 3831 5380510 SGTC_2733 amorolfine 100 µM -0.821631968112097 0.224500443030657 no 2619 0.205643194654088 3888 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1563 conessine 56.1 µM -0.821736169554417 0.224469845309881 no 2620 0.205613534483646 3931 441082 An anti-amoebic, histamine inhibitor. SGTC_1953 st076800 12.1 µM -0.822449110813696 0.224260560672491 no 2621 0.205410669158262 3912 297591 SGTC_117 lucigenin 22.078 µM -0.826809932509883 0.222982850861349 no 2622 0.204172399719074 3907 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3293 9120939 62.045 µM -0.828172332277932 0.222584522810974 no 2623 0.203786455204535 3857 934087 SGTC_2081 5214970 32.255 µM -0.828812121154204 0.222397606295406 no 2624 0.203605364141093 3785 2063512 SGTC_3120 9124077 49.47 µM -0.829141335511237 0.222301460089609 no 2625 0.203512218030954 3937 18774327 YGL155W CDC43 SGTC_1282 0886-0010 32.4 µM -0.829195795881976 0.222285557364724 no 2626 0.203496811761926 3937 2836211 YNL267W PIK1 SGTC_1245 0418-0076 17.2 µM -0.829466804611634 0.222206430991679 no 2627 0.203420156573246 3941 6790114 SGTC_355 1311-2252 105 µM -0.832755627985791 0.221247475754353 no 2628 0.202491282161436 3884 5338538 SGTC_3043 9092303 49.47 µM -0.833546123734694 0.221017336343038 no 2629 0.202268398141373 3887 25236084 SGTC_3234 9132280 49.47 µM -0.834718892866129 0.220676157068424 no 2630 0.201938000818462 3929 17612295 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.834943072634288 0.220610973572502 no 2631 0.201874880776098 3898 6708784 An antioxidant flavonoid SGTC_2997 9067075 71.4286 µM -0.835032973922287 0.220584836577384 no 2632 0.201849571493347 3912 27209819 SGTC_677 0929-0063 136 µM -0.835172174046792 0.220544370435388 no 2633 0.201810387201263 3854 1539583 SGTC_1300 1094-0077 113 µM -0.835369460507096 0.220487025604685 no 2634 0.201754859635217 3834 5532636 SGTC_2117 5521686 200 µM -0.836260653278271 0.220228091023898 no 2635 0.201504141633109 3840 803312 SGTC_749 1000-0129 128 µM -0.836773582770269 0.220079139307091 no 2636 0.201359924589463 3942 708470 SGTC_3356 9151811 4.48 µM -0.837235860905795 0.219944945972923 no 2637 0.201230001877951 3874 1859254 YPR165W RHO1 SGTC_471 1-acyl-paf 4 µM -0.837338099226903 0.219915273858801 no 2638 0.201201274710027 3825 16759367 SGTC_2070 5230947 200 µM -0.838248740007372 0.219651084535122 no 2639 0.200945509198125 3944 2835538 SGTC_315 k915-0449 187 µM -0.842328515409516 0.218469725572343 no 2640 0.199802046958209 3910 20970215 YNL149C PGA2 SGTC_848 0368-0089 85.6 µM -0.842338715459544 0.218466776590716 no 2641 0.199799193044932 3905 762535 SGTC_2106 5357045 167.29 µM -0.843391959848944 0.218162391859204 no 2642 0.199504633539463 3929 668842 SGTC_1283 0922-0125 16.4 µM -0.844014181081875 0.21798268653814 no 2643 0.199330740614495 3905 3360884 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.844219940744856 0.217923279341738 no 2644 0.199273256797585 3928 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2003 4023581 200 µM -0.845412716002728 0.217579083702227 no 2645 0.198940223607207 3942 16641307 SGTC_715 0868-0130 184 µM -0.845628187566326 0.217516939183155 no 2646 0.198880097869709 3917 2876258 SGTC_427 1354-0053 47.3 µM -0.846435362522673 0.217284231581156 no 2647 0.198654959087898 4025 6813657 SGTC_3149 9097855 49.47 µM -0.846898416777778 0.21715079850449 no 2648 0.19852587251563 3919 25236625 YMR079W SEC14 SGTC_1155 4088-0394 48.2 µM -0.847397931549802 0.217006912105964 no 2649 0.198386678518815 3880 2326248 SGTC_1844 rapamycin 4 nM -0.847835995968997 0.216880771986169 no 2650 0.198264656662201 3836 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1780 st038448 24.544 µM -0.848056070051006 0.21681741791974 no 2651 0.198203372621912 3965 728868 YDL195W SEC31 SGTC_1071 trifluoperazine 6.31 µM -0.850631955272504 0.216076678128431 no 2652 0.197486916294167 4003 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_463 ikarugamyin 104 µM -0.850688220132533 0.216060514582246 no 2653 0.197471284290048 3948 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1298 1079-1278 263 µM -0.850973793003238 0.215978487137737 no 2654 0.197391955429766 3921 2840950 SGTC_268 camptothecin 39.6153 µM -0.853356165967234 0.215294881982587 no 2655 0.196730910943165 3879 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2790 5423970 71.43 µM -0.853675965404997 0.215203213466084 no 2656 0.196642277373963 3981 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2592 piperlongumine 83.33 µM -0.858107793895086 0.213935191688696 no 2657 0.195416472039715 3937 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2251 lansoprazole 556 µM -0.860099674582813 0.213366700413671 no 2658 0.194867050295477 3830 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1485 3909-9022 254 µM -0.860280175294094 0.213315228292061 no 2659 0.194817309131897 3956 714516 SGTC_2894 9048625 32.47 µM -0.860794239441517 0.213168675900694 no 2660 0.194675689136828 3917 4092861 SGTC_1006 4099-6547 255 µM -0.861089378152852 0.213084562585881 no 2661 0.194594409418325 3958 3146833 SGTC_1594 piperine 70.1 µM -0.862515873280152 0.212678290392731 no 2662 0.194201851017942 3902 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3221 9128209 49.47 µM -0.862834862298862 0.212587502812672 no 2663 0.194114134191142 3963 16460723 SGTC_3044 9093193 49.47 µM -0.865291556660137 0.211889060942394 no 2664 0.193439391946751 3924 25236277 SGTC_804 1595-0054 20.9 µM -0.865635978340127 0.211791248751334 no 2665 0.193344909466823 3869 761523 Stimulates phospholipase C. SGTC_40 0327-0103 19.753 µM -0.866035912142248 0.211677704849791 no 2666 0.193235234125212 3813 409036 SGTC_523 1934-0222 13.7 µM -0.867135498986014 0.211365708435971 no 2667 0.192933886091986 3903 1361595 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.869201103649529 0.210780343230425 no 2668 0.192368571938157 3953 5357218 A potent inhibitor of glutathione S-transferases. SGTC_676 falcarinol 140 µM -0.86947709665929 0.210702202514539 no 2669 0.192293115027849 3909 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1807 st050092 58.9 µM -0.869638921378854 0.210656393680847 no 2670 0.192248880322385 3958 5008496 SGTC_3051 9093778 49.47 µM -0.86964503528459 0.210654663090159 no 2671 0.192247209211364 3961 17217378 SGTC_2188 6126565 140.678 µM -0.870512660115755 0.210409159426214 no 2672 0.192010151822807 3856 874518 SGTC_3019 9081971 49.47 µM -0.871684197286846 0.210077927195691 no 2673 0.191690341779877 3951 16451803 SGTC_549 1661-1316 519 µM -0.871912030308929 0.210013546878622 no 2674 0.191628185087574 3923 2857282 SGTC_3323 9138564 53.9225 µM -0.872367463220643 0.209884886877283 no 2675 0.191503972313294 3956 43912313 YNL103W MET4 SGTC_2580 diallyl disulphide 81.36 µM -0.872517691983706 0.209842457347861 no 2676 0.191463010401251 3936 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3206 9114350 49.47 µM -0.872772554759848 0.209770487275332 no 2677 0.191393530885063 3847 17087243 SGTC_2895 9054447 58.44 µM -0.87277517378966 0.209769747769284 no 2678 0.191392816977433 3971 2697450 SGTC_1389 3405-0187 19 µM -0.872842498659665 0.2097507385276 no 2679 0.191374465803586 3898 799890 SGTC_642 0335-0876 158 µM -0.875660039402044 0.208956111691621 no 2680 0.190607437690181 3965 6812350 SGTC_2124 5246320 200 µM -0.87604159107347 0.208848639731507 no 2681 0.190503711937318 3957 579342 SGTC_2778 tioconazole 65.09 nM -0.876148409579108 0.208818557914892 no 2682 0.190474679276622 3848 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2952 9073731 13.78 µM -0.876496971861897 0.208720414905298 no 2683 0.190379960934555 4010 16457353 SGTC_1620 st003704 16.5 µM -0.876589969510918 0.208694234598302 no 2684 0.19035469463556 3854 2834414 SGTC_675 1309-0189 238 µM -0.87695074761146 0.208592688185464 no 2685 0.190256695228905 3964 4246530 SGTC_2830 7992007 71.43 µM -0.877532460583549 0.208429017698896 no 2686 0.190098747808003 3830 1952075 SGTC_1035 k081-0041 55.2 µM -0.878505944250838 0.208155288286227 no 2687 0.189834606651176 3916 731709 SGTC_1175 0741-0056 27.6 µM -0.8797902322433 0.207794489975703 no 2688 0.189486478548579 4043 765927 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.879875999814575 0.20777040823696 no 2689 0.18946324379194 4001 165506 SGTC_398 bronopol 33.3 µM -0.879885649391661 0.207767698940868 no 2690 0.189460629795056 3844 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_589 1227-0070 34.1 µM -0.879938510036351 0.207752857713747 no 2691 0.189446310643112 3982 2841384 SGTC_58 0957-0393 9 µM -0.88097857853632 0.207460974048883 no 2692 0.189164707245982 3797 6997992 SGTC_1713 st033146 12.748 µM -0.88381568411145 0.206666005333505 no 2693 0.188397859181097 3910 674619 SGTC_377 3970-0964 33.1 µM -0.884158823831523 0.206569978598404 no 2694 0.188305241279523 3918 16481235 SGTC_3227 9130768 49.47 µM -0.884564206464561 0.20645656741022 no 2695 0.18819585940291 3968 17720899 SGTC_3337 9144342 33.5465 µM -0.88570602979847 0.20613732548132 no 2696 0.187887979110705 3953 17682949 SGTC_281 1672-3440 14.9 µM -0.888150704653261 0.205454804738388 no 2697 0.187229845570937 3998 6833000 SGTC_2381 9035592 200 µM -0.888447891758162 0.205371925627483 no 2698 0.187149936804233 3952 4749657 SGTC_3208 9114115 49.47 µM -0.889331293086414 0.205125681210363 no 2699 0.186912529153475 3988 650895 SGTC_49 0717-0965 32.132 µM -0.890204439063315 0.204882467930806 no 2700 0.186678060762098 3989 5889349 YGL099W LSG1 SGTC_1221 2958-7315 257 µM -0.89283851804326 0.204149789487722 no 2701 0.18597182791084 3974 4562705 SGTC_297 0986-0032 24 µM -0.895203099168657 0.203493403950128 no 2702 0.185339264172145 3923 2847425 SGTC_1380 2291-0730 164 µM -0.895812600006449 0.20332441652169 no 2703 0.18517642962569 4003 2999191 SGTC_1922 5578187 25 µM -0.896287767582686 0.203192731830577 no 2704 0.185049545276802 3982 1350412 SGTC_1396 3511-0007 98.6 µM -0.897001251302329 0.202995097472004 no 2705 0.184859124660853 3976 X1396 SGTC_3280 9140961 49.47 µM -0.897205952948761 0.202938416496311 no 2706 0.18480451463084 4006 4901226 SGTC_3191 9110352 49.47 µM -0.898131588135851 0.202682230263891 no 2707 0.1845577001315 3908 17122424 SGTC_2316 5844804 197.44 µM -0.898138398497949 0.202680346089853 no 2708 0.184555884953519 4015 776813 SGTC_3061 glucosamine 200 µM -0.898454234768962 0.202592977433363 no 2709 0.184471716744963 3846 91431 and experimental redox chemotherapeutic SGTC_1182 1222-0449 220 µM -0.899018883380546 0.202436836819582 no 2710 0.184321301258578 3966 658318 SGTC_499 genistein 192 µM -0.903702371259769 0.201144501607535 no 2711 0.18307662070835 4009 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1177 0983-0204 23.6 µM -0.903872798336034 0.201097568405135 no 2712 0.183031427222079 4018 766818 SGTC_3141 9094609 49.47 µM -0.908811926902388 0.199740257532574 no 2713 0.181724704899235 3934 25236309 YDL196W YDL196W SGTC_2756 carbadox 75.1 µM -0.909951258482982 0.199427944433025 no 2714 0.181424107732025 3971 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2561 acetosyringone 100 µM -0.913845925840568 0.19836256200508 no 2715 0.180398905274725 3988 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_720 r052-1644 49.9 µM -0.915331158935232 0.197957184256649 no 2716 0.180008903084194 4013 1422863 YOR257W CDC31 SGTC_63 0099-0242 26.702 µM -0.915568402249279 0.197892477728279 no 2717 0.17994665526062 4035 3898502 YLR359W ADE13 SGTC_2031 5180455 200 µM -0.915832457348218 0.197820473491155 no 2718 0.179877388467386 3935 29949 SGTC_755 1995-0008 37.3 µM -0.917680117157444 0.197317084796688 no 2719 0.17939317999196 3953 689533 SGTC_753 1322-0200 289 µM -0.917691835390015 0.197313894678252 no 2720 0.179390111661285 4077 5403907 SGTC_2213 7173844 200 µM -0.917784517214592 0.197288664498239 no 2721 0.179365844788198 3947 892728 SGTC_2622 2-methoxyxanthone 59.94 µM -0.91853233452963 0.197085162381688 no 2722 0.179170119373309 4008 71034 A hepatoprotective. SGTC_1529 apigenin 74 µM -0.918987692046725 0.196961309048914 no 2723 0.17905100497678 4006 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2462 5162487 171.77 µM -0.919008653891051 0.196955608741936 no 2724 0.179045522886347 3878 2259986 SGTC_873 0591-4978 488 µM -0.919295577736439 0.196877593490548 no 2725 0.178970495140202 4094 3305145 SGTC_1757 st041620 31.8375 µM -0.919822203199293 0.196734451513573 no 2726 0.178832839282229 4074 5289815 SGTC_810 3825-7150 143 µM -0.920559942993417 0.196534032617505 no 2727 0.178640111866326 4066 22330411 YGL099W LSG1 SGTC_1657 st012939 43.4 µM -0.921266819047049 0.196342114456283 no 2728 0.178455570052063 4019 24207257 SGTC_999 SEC7.066 22.7 µM -0.922196226465893 0.196089951565048 no 2729 0.178213115528672 3979 740511 YDR170C SEC7 SGTC_754 3474-0146 171 µM -0.924749299925917 0.195398274027627 no 2730 0.177548164334684 3963 24762078 SGTC_853 0419-0306 21 µM -0.926078906337422 0.195038645276209 no 2731 0.177202487591086 4020 762713 SGTC_2702 st077768 96.8 µM -0.926118206301041 0.195028021642509 no 2732 0.177192276690935 4001 6484119 SGTC_2281 7943571 200 µM -0.928287385175703 0.194442191192473 no 2733 0.176629257956749 4107 1244024 SGTC_506 n9-isopropylolomoucine 153 µM -0.929223286314498 0.19418976337717 no 2734 0.176386690929092 4022 6610355 SGTC_1714 st033236 13.627 µM -0.9301504564844 0.193939887356863 no 2735 0.176146594713385 4036 2916566 SGTC_2719 novobiocin 32.65 µM -0.930879306129271 0.193743597123964 no 2736 0.175958000072617 4009 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.932696786316206 0.193254650078824 no 2737 0.175488272320907 4047 688664 SGTC_2436 5633522 8.09 µM -0.933048559023013 0.193160101596382 no 2738 0.175397448553935 3991 5724242 SGTC_3121 9125696 49.47 µM -0.93360346042337 0.193011014168633 no 2739 0.175254239828299 4073 1235365 SGTC_2442 5158906 48.48 µM -0.936526662332657 0.192226787317031 no 2740 0.174501045756305 4046 1893835 SGTC_3196 9111891 49.47 µM -0.939958049333029 0.191308717146522 no 2741 0.17361953969262 4000 18891510 SGTC_1870 st057514 26.5 µM -0.940192832166613 0.191245999209226 no 2742 0.173559328905527 4007 5393161 SGTC_3171 9103192 49.47 µM -0.941725074308205 0.190836998380884 no 2743 0.173166707040402 4045 13018434 SGTC_3275 9138069 49.47 µM -0.94315434841966 0.190455966952973 no 2744 0.172800980048057 4108 17617007 SGTC_850 0388-0143 75.9 µM -0.944280257352901 0.190156139111248 no 2745 0.172513225971008 3979 67273 SGTC_2157 5649910 96.377 µM -0.946168140396448 0.189654050030505 no 2746 0.172031416640747 4014 2858091 SGTC_892 0929-0076 29 µM -0.946578755377501 0.189544953614161 no 2747 0.171926736847318 4010 5751038 SGTC_507 nimesulide 162 µM -0.946610296686894 0.189536574991527 no 2748 0.17191869757184 4086 4495 A COX2 inhibitor. SGTC_536 3852-0578 10.6 µM -0.946768109582726 0.189494657050446 no 2749 0.171878477693047 4088 2869208 SGTC_110 0850-0284 111.64 µM -0.946886202327602 0.189463293227138 no 2750 0.171848384743068 3819 3906265 SGTC_1645 Cervolide 78 µM -0.947164119286897 0.18938949487733 no 2751 0.171777577910562 4006 23173 A fragrance. SGTC_505 gw-5074 63.9 µM -0.947596859623127 0.189274619799423 no 2752 0.17166736275304 4081 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2991 9074669 71.4286 µM -0.95125957664651 0.188304035325959 no 2753 0.170736310922067 4034 17333109 SGTC_2243 6634756 200 µM -0.952142475525191 0.188070535770408 no 2754 0.17051236497476 4125 885676 SGTC_2133 5320837 200 µM -0.952233318052902 0.188046520864651 no 2755 0.170489333583697 4074 2841355 SGTC_734 2023-0417 80 µM -0.953091707958698 0.187819692491545 no 2756 0.170271803541935 4045 3935732 SGTC_1154 4088-0362 150 µM -0.95451897988742 0.187442912058955 no 2757 0.169910503302401 4027 6618304 SGTC_3245 9134821 49.47 µM -0.957060855327643 0.186773049273507 no 2758 0.169268269953109 4033 17014901 SGTC_3335 9143315 29.6265 µM -0.957713595494991 0.186601271450356 no 2759 0.169103599625674 4050 4899691 SGTC_395 anisomycin 6.25 µM -0.959667684641152 0.186087610247673 no 2760 0.168611246085414 4058 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_984 1492-0255 2.91 µM -0.960732775845316 0.185808004713092 no 2761 0.168343273432425 4013 1585198 SGTC_993 3909-8757 62.7 µM -0.96192150000609 0.185496251193693 no 2762 0.168044518860564 3997 4288324 YLR208W SEC13 SGTC_2376 9072922 81.32 µM -0.963326275876007 0.185128254974745 no 2763 0.167691905510229 4088 17087968 SGTC_219 mitoxanthrone 164.414 µM -0.966185272630405 0.184380711663723 no 2764 0.166975740466547 4003 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2319 6033012 152.6 µM -0.966616446585126 0.184268135582415 no 2765 0.166867904874491 4002 847246 SGTC_618 k072-0232 33.2 µM -0.967354062205476 0.184075649224762 no 2766 0.166683533129345 4083 5872756 YGL099W LSG1 SGTC_724 3910-0327 137 µM -0.968245248361366 0.183843254525124 no 2767 0.16646095087558 4113 2885483 SGTC_1184 1269-1718 139 µM -0.968267189238825 0.183837535306279 no 2768 0.16645547335329 4128 5403821 SGTC_1387 3342-1166 1.8 µM -0.96842828974452 0.183795545436941 no 2769 0.166415258306509 4027 3418228 SGTC_1775 st081588 35.1725 µM -0.968548546653596 0.183764205097829 no 2770 0.166385243016406 4058 1426443 YGL099W LSG1 SGTC_3249 9135183 49.47 µM -0.97226891222375 0.182796279990692 no 2771 0.165458392686546 4066 4902779 SGTC_2710 st078562 53.7235 µM -0.972398692776189 0.182762572613824 no 2772 0.165426121011209 3999 17250908 SGTC_80 0159-0065 512.242 µM -0.972904400974409 0.182631264095063 no 2773 0.165300408735453 3929 1548079 SGTC_3241 9133421 49.47 µM -0.974496069262124 0.182218367693899 no 2774 0.16490514494336 4076 17018221 SGTC_2701 st077767 14.721 µM -0.975514401922871 0.181954507199689 no 2775 0.164652580665423 4034 5721188 SGTC_1365 1672-3266 55.4 µM -0.978247246556443 0.18124758073403 no 2776 0.163976027038102 4110 6415873 SGTC_69 0096-0274 206.684 µM -0.979726631540325 0.180865615148887 no 2777 0.163610538295562 4216 6741392 SGTC_484 loperamide 105 µM -0.97989993910218 0.180820901535497 no 2778 0.163567756517747 4046 3955 An opioid-receptor agonist. SGTC_3290 9121031 71.43 µM -0.980008174382973 0.180792980184477 no 2779 0.163541041820476 4086 17014854 SGTC_2628 lathosterol 100 µM -0.981837781773801 0.180321407186045 no 2780 0.163089885810708 4153 6710616 SGTC_701 4424-0219 185 µM -0.985374305110385 0.179412074552684 no 2781 0.16222012308904 4120 2911779 SGTC_1261 0712-0010 12.7 µM -0.986411252648805 0.179145995754878 no 2782 0.161965672721621 4103 2840123 SGTC_2273 7815444 169.05 µM -0.986618327470053 0.179092890492733 no 2783 0.161914891027662 4029 2824616 SGTC_2497 7-hydroxyflavone 100 µM -0.99016052596249 0.178186011995011 no 2784 0.16104783163184 4109 5281894 SGTC_2437 5741531 144.16 µM -0.990365789202762 0.178133549094758 no 2785 0.160997680345677 4111 2262990 SGTC_2575 plumbagin 510 nM -0.992551060157796 0.177575622984002 no 2786 0.160464392318879 3989 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1853 st056710 91.2 µM -0.99684617814998 0.176482245452855 no 2787 0.159419589879583 4150 269167 SGTC_2434 5670830 169.91 µM -0.996959320262248 0.176453501356415 no 2788 0.159392128007296 4129 1549830 SGTC_1234 0326-0494 15.5 µM -0.997584448644547 0.176294738985788 no 2789 0.159240452578443 4170 1547813 SGTC_467 ro 31-8220 72.8 µM -0.998454642337127 0.176073888500112 no 2790 0.159029474173479 4026 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2197 6588183 93.1375 µM -0.998715121018326 0.176007814485546 no 2791 0.158966356765945 4046 884136 SGTC_2232 chlorophetanol 41.5365 µM -0.998982025213994 0.175940126837722 no 2792 0.158901699401771 4155 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2782 7736369 71.43 µM -1.00102200724084 0.175423326301147 no 2793 0.158408084467971 4124 2950836 YOL077C BRX1 SGTC_2078 5212016 200 µM -1.00103474590517 0.175420102167407 no 2794 0.158405005253983 3944 1899708 SGTC_1021 4476-0760 85.3 µM -1.00187810010403 0.175206734259882 no 2795 0.158201235435144 4093 746768 SGTC_1779 st039427 55 µM -1.00343916707707 0.174812220130959 no 2796 0.157824507178416 4038 1124498 SGTC_2386 9075165 157.42 µM -1.00355591014646 0.174782739403755 no 2797 0.157796357572819 4062 16452277 SGTC_812 4251-0442 148 µM -1.00468996189238 0.174496525446986 no 2798 0.157523081607526 4138 5723007 SGTC_1376 2910-0861 41.3 µM -1.00506701371727 0.174401430427622 no 2799 0.157432291192033 4039 1112859 SGTC_988 1497-1057 103 µM -1.00512879804258 0.174385851142941 no 2800 0.157417417407098 4036 3533044 SGTC_301 4119-0100 24.5 µM -1.0072115217047 0.17386119729052 no 2801 0.156916568715457 4110 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_733 4069-0007 56.1 µM -1.00791687264904 0.173683741841328 no 2802 0.156747185425686 4093 5717425 YNL287W SEC21 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.00943337230609 0.173302604208777 no 2803 0.156383420148007 4120 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_291 SEC14.278 35.5 µM -1.00995434568956 0.173171792407483 no 2804 0.156258581813584 4146 1068044 SGTC_525 k781-2675 26.7 µM -1.01066233140582 0.172994124289716 no 2805 0.156089035874613 4067 3651118 YDL195W SEC31 SGTC_2276 7947513 42.08 µM -1.01173113715061 0.172726128920062 no 2806 0.1558333117493 4057 2105100 SGTC_2984 9022109 38.96 µM -1.01203781537783 0.172649280444748 no 2807 0.155759986468208 4126 6459207 SGTC_1746 st038117 42 µM -1.01253186205648 0.172525526396096 no 2808 0.155641910150739 4164 2898218 SGTC_1112 tnp00069 1.16933 µM -1.01276082988374 0.172468191296398 no 2809 0.155587207254419 4119 145826 SGTC_534 k292-0788 63.4 µM -1.01399499341984 0.17215935768057 no 2810 0.155292570636471 4151 4146317 SGTC_1156 4092-0367 4.88 µM -1.01501109679384 0.171905355899645 no 2811 0.155050268941577 4115 1357585 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.0174440600737 0.171298145673703 no 2812 0.154471115485179 4155 6708760 SGTC_2240 6690706 185.951 µM -1.01798216383318 0.171164033070671 no 2813 0.154343216230505 3956 805876 SGTC_760 0568-0725 82.9 µM -1.01907664843463 0.170891459873309 no 2814 0.154083289641564 4138 3916171 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.01976054516244 0.170721281583027 no 2815 0.153921019700186 4092 6708739 YPR165W RHO1 SGTC_1052 3253-3998 198 µM -1.02051499216098 0.170533673706284 no 2816 0.153742141350725 4044 5450317 SGTC_10 0279-0212 42.575 µM -1.02360389467433 0.169766935512671 no 2817 0.153011202456139 4093 39851 YBR002C RER2 SGTC_1302 1159-0335 255 µM -1.02558117249164 0.169277291067434 no 2818 0.152544522883152 4127 649284 SGTC_91 0417-1751 58.384 µM -1.02643700458816 0.16906563794552 no 2819 0.152342821490098 4237 6795624 SGTC_2258 7960471 200 µM -1.0280635957412 0.168663839533648 no 2820 0.151959956787409 4161 2974708 SGTC_1039 k821-0043 94 µM -1.03150485499394 0.167815808796976 no 2821 0.15115206633838 4143 15992768 SGTC_1982 st072467 71.9 µM -1.03157854783227 0.167797678719526 no 2822 0.151134797080025 4092 3163533 SGTC_1701 st028638 40.4 µM -1.03301639295481 0.167444189209182 no 2823 0.150798113597552 4129 3490878 SGTC_2564 betulinic acid 100 µM -1.03330918552507 0.167372265958837 no 2824 0.150729615004925 4182 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1425 4048-4433 7.33 µM -1.0341185773948 0.167173545888947 no 2825 0.15054036622188 4186 23734946 SGTC_1732 st034308 51.822 µM -1.03613160559043 0.166679971609961 no 2826 0.150070374569498 3992 830119 SGTC_2571 chrysanthemic acid 100 µM -1.03745127527422 0.166356912714076 no 2827 0.14976279618261 4148 2743 An insecticide. SGTC_328 k915-0120 63.5 µM -1.03889142060846 0.166004822734951 no 2828 0.149427618457553 4111 6624543 SGTC_1486 3970-0793 4.53 µM -1.03943708070048 0.165871544406291 no 2829 0.149300753075853 4144 2844330 SGTC_1489 4065-0444 182 µM -1.0415596135601 0.16535377041813 no 2830 0.148807950580047 4116 2877968 SGTC_17 0960-0276 49.807 µM -1.04294660264884 0.165015991704557 no 2831 0.148486512072988 4112 6821114 SGTC_887 0885-0007 9.62 µM -1.04312361463603 0.16497291547297 no 2832 0.148445522496495 4205 5719458 SGTC_2852 9023854 51.95 µM -1.04461910725015 0.164609274917513 no 2833 0.148099522520606 4198 19798528 SGTC_1768 st044301 37.178 µM -1.04483901678417 0.164555846056803 no 2834 0.148048689390308 4151 3931349 SGTC_3087 9117406 49.47 µM -1.04572464390458 0.164340789323065 no 2835 0.147844090706173 4159 42546093 SGTC_103 0844-0104 51.839 µM -1.04576028434559 0.16433213857463 no 2836 0.147835860971354 4047 5375804 SGTC_397 arbidol 50 µM -1.04597834078537 0.164279217729262 no 2837 0.147785516234383 4181 131410 A RNA synthesis inhibitor. SGTC_2016 5121758 140 µM -1.04819440794815 0.163742019908037 no 2838 0.147274523227806 4061 2795203 SGTC_3239 9133757 49.47 µM -1.04870786573444 0.163617715269071 no 2839 0.147156296477548 4162 17036923 SGTC_1704 st028805 70.8 µM -1.04986752630044 0.163337194850111 no 2840 0.146889511831535 4175 2876101 SGTC_2521 angolensin 13.4 µM -1.05555651055243 0.161965565803628 no 2841 0.145585439366309 4186 821428 A flavenoid. SGTC_1943 st076331 65.2 µM -1.05749393115089 0.161500166317436 no 2842 0.145143111452804 4158 24208415 SGTC_1479 0549-0158 134 µM -1.05836501211162 0.161291203134703 no 2843 0.144944532054602 4199 5440202 SGTC_2679 rapamycin 1 nM -1.0596785982862 0.1609764212484 no 2844 0.144645421247397 4073 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2945 9067681 61.76 µM -1.06264475982261 0.160267099609262 no 2845 0.143971540311462 4231 16456930 SGTC_624 k048-0052 28 µM -1.06281726596393 0.160225909807611 no 2846 0.143932413979119 4143 6835531 SGTC_974 1326-0144 138 µM -1.06289300898591 0.160207826608524 no 2847 0.143915236876288 4177 5411856 SGTC_2675 theaflavin digallate 100 µM -1.0661625981894 0.159428503310199 no 2848 0.143175073134811 4100 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1102 cgs 12066b 26.1 µM -1.06649148854965 0.159350248226602 no 2849 0.143100762116962 4161 6438352 A 5-HT1B full agonist. SGTC_2468 5987765 72.9 µM -1.06922322165634 0.158701240878849 no 2850 0.142484548694003 4201 26772094 SGTC_781 4335-2806 94.4 µM -1.06965517066841 0.158598776986597 no 2851 0.142387275940488 4226 845254 SGTC_255 tunicamycin 200.472 nM -1.07461463874966 0.157425436144768 no 2852 0.141273647570344 4092 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2614 arthonioic acid 13.39 µM -1.07687296100087 0.156893043986719 no 2853 0.140768512131739 4034 6710684 SGTC_1000 4048-0884 8.67 µM -1.07692112651698 0.156881702039546 no 2854 0.140757751963644 4211 13040088 SGTC_1297 1068-0111 14.1 µM -1.07699172994581 0.15686507741963 no 2855 0.140741980178347 4146 767057 SGTC_909 3448-9333 149 µM -1.07784741189504 0.156663686627144 no 2856 0.140550928538296 4095 3344074 SGTC_2556 citropten 84.59 µM -1.0785336537587 0.156502297786704 no 2857 0.140397835750469 4205 2775 A potential DNA crosslinker. SGTC_1747 st037496 66.6 µM -1.08011390863088 0.156131073384255 no 2858 0.140045729493599 4144 723305 SGTC_358 0075-0058 9.45 µM -1.08033323604998 0.156079596136696 no 2859 0.139996907267515 3985 1069125 SGTC_1125 tnp00248 1.32998 µM -1.08085601123713 0.155956943278584 no 2860 0.139880584289248 4251 24207736 SGTC_2383 9036125 200 µM -1.08260063936281 0.155548080731239 no 2861 0.139492861700315 4101 79580 SGTC_980 1473-0395 201 µM -1.08261600083869 0.155544483833853 no 2862 0.139489451046907 4060 768876 SGTC_1015 4130-4525 82 µM -1.08341052649512 0.155358520057475 no 2863 0.139313122696415 4178 1363237 SGTC_476 mead acid 10 µM -1.08362454894458 0.155308451838356 no 2864 0.139265650829817 4208 5312531 An omega 9 fatty acid. SGTC_1959 st077091 55.8 µM -1.08447312829846 0.155110040776881 no 2865 0.139077537587802 4171 821356 YKL052C ASK1 SGTC_783 0848-0141 92.7 µM -1.08489080954174 0.155012441887105 no 2866 0.138985009472555 4104 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3145 9085516 49.47 µM -1.08526646953572 0.154924696680029 no 2867 0.138901826048005 4199 25236195 SGTC_2256 7954252 200 µM -1.08567429943998 0.154829474495742 no 2868 0.138811557537712 4194 2972920 SGTC_2760 etidronate 98.04 µM -1.08584549880988 0.154789513526674 no 2869 0.13877367641256 4131 3305 A chelator and antioxidant. SGTC_2563 tomatine 8.54 µM -1.08602959466114 0.154746549893828 no 2870 0.138732949551891 4136 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3311 9131146 2.8755 µM -1.09028637679202 0.15375531471772 no 2871 0.137793507168279 4146 4900406 YPR165W RHO1 SGTC_1028 k015-0029 4.8 µM -1.0913925188184 0.153498427782327 no 2872 0.137550101440092 4134 4588309 SGTC_2601 securinine 100 µM -1.0932419246531 0.153069562888717 no 2873 0.137143796998829 4159 442872 A GABA receptor antagonist. SGTC_2587 piperic acid 92.2 µM -1.09374809835082 0.152952323151395 no 2874 0.13703273643359 4178 5370536 SGTC_878 0828-0289 13.7 µM -1.09554767501402 0.152535988172063 no 2875 0.1366383854931 4127 745350 YLR208W SEC13 SGTC_1889 st059080 5.18 µM -1.0965070210163 0.152314349486461 no 2876 0.136428476240805 4154 176925 Isolated from Daphnopsis sellowiana. SGTC_3184 9108758 49.47 µM -1.10162467970532 0.15113562507436 no 2877 0.135312437174308 4212 902885 SGTC_1063 disulfiram 1.84 µM -1.10212070829006 0.15102170081768 no 2878 0.135204598828505 4214 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.10294693934972 0.150832064949781 no 2879 0.135025104156648 4205 521171 SGTC_181 1447-1644 8.07 µM -1.10393528048179 0.150605430026264 no 2880 0.134810606621391 4188 534600 SGTC_788 1182-0090 188 µM -1.10453441763723 0.150468153314923 no 2881 0.134680691059558 4223 5715185 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.10479497698633 0.150408478926881 no 2882 0.134624218769095 4168 689007 SGTC_2875 9039966 71.43 µM -1.10734686221054 0.149824869043611 no 2883 0.134071995323877 4213 6463691 SGTC_1911 st060208 74.3 µM -1.10946943485524 0.149340594038512 no 2884 0.133613861496273 4237 688783 SGTC_2674 ligustilide 100 µM -1.11046189890958 0.149114517610655 no 2885 0.133400018864255 4253 5319022 A signalling regulator. SGTC_1249 0481-0015 10.2 µM -1.11210689453982 0.148740302692457 no 2886 0.133046096352831 4137 4227577 SGTC_1452 4194-0072 190 µM -1.12016110795758 0.146917141210502 no 2887 0.131322557004641 4279 1343545 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.12186447450582 0.146533493421373 no 2888 0.130960033775347 4243 4620898 SGTC_2145 5634607 200 µM -1.1228645870171 0.146308552521817 no 2889 0.130747504830188 4183 308662 SGTC_2729 fluphenazine 10.66 µM -1.12362341661146 0.146138034698137 no 2890 0.130586408877307 4139 3372 An atypical antipsychotic. SGTC_1633 st005664 67.9 µM -1.12362647627128 0.146137347427353 no 2891 0.130585759603852 4218 2063822 SGTC_1023 4482-3888 16 µM -1.12406305430617 0.146039304099161 no 2892 0.130493138680148 4227 3303168 SGTC_2600 tangeritin 87.95 µM -1.12561965170745 0.145690095194342 no 2893 0.13016327317082 4157 68077 A bioactive flavone. SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.12608958714648 0.145584779733188 no 2894 0.130063800546016 4309 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_371 0195-0006 7.36 µM -1.12959061297308 0.144801789520106 no 2895 0.129324384122713 4040 3928593 SGTC_1709 st033179 39.1045 µM -1.1297738601606 0.144760885276557 no 2896 0.12928576272444 4218 573381 SGTC_1784 st039334 36.3 µM -1.1370533435135 0.143142260162553 no 2897 0.127757993282619 4288 3496984 SGTC_2885 9057732 51.95 µM -1.13718065610421 0.143114060858479 no 2898 0.127731385883542 4288 6471414 SGTC_2287 7945887 168.79 µM -1.13989792574235 0.142513089721302 no 2899 0.127164414662964 4249 1245853 SGTC_83 0170-0301 39.027 µM -1.14027347575018 0.142430164791148 no 2900 0.127086192313537 4231 3089716 SGTC_2911 7942208 15.64 µM -1.14203014759609 0.142042708790873 no 2901 0.126720744284298 4269 1243384 SGTC_448 monastrol 171 µM -1.14324694157258 0.141774748264686 no 2902 0.126468038765241 4154 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2144 5628481 200 µM -1.14388558517655 0.141634244224599 no 2903 0.126335544928237 4228 2818399 SGTC_3115 9123671 49.47 µM -1.1454749059907 0.141284997138558 no 2904 0.126006242319908 4352 3286988 SGTC_2234 tolnaftate 200 µM -1.14699854076868 0.140950732833776 no 2905 0.125691112007117 4306 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2865 9030313 51.95 µM -1.147366351278 0.140870120761259 no 2906 0.125615120957013 4199 42562754 SGTC_2279 7948423 32.93 µM -1.14846050411462 0.140630503068675 no 2907 0.125389254361074 4232 1247112 SGTC_1264 0783-0040 158 µM -1.14858809142081 0.140602579676458 no 2908 0.125362934908156 4136 2855798 SGTC_1546 5-methoxyflavanone 78.7 µM -1.1488400945001 0.140547438062474 no 2909 0.125310961576162 4246 147795 SGTC_3229 9132204 49.47 µM -1.14922104632902 0.140464108625292 no 2910 0.125232422304415 4298 17682924 SGTC_1604 st002052 72.4 µM -1.14944422284958 0.140415306557626 no 2911 0.125186426888138 4326 6254834 YHR062C RPP1 SGTC_1014 4130-3005 69.3 µM -1.14959152536712 0.140383102185592 no 2912 0.125156075137114 4249 743608 SGTC_1446 4239-0190 62 µM -1.15062903163964 0.140156416918381 no 2913 0.124942442059509 4253 1340085 SGTC_2912 7964298 10.93 µM -1.15094337238852 0.140087785559269 no 2914 0.124877766420277 4247 2975850 SGTC_2019 4016004 108 µM -1.15095774712354 0.14008464760798 no 2915 0.124874809376562 4277 45595336 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.15231581686343 0.139788401395167 no 2916 0.124595659867043 4234 2346 DNA damaging agent; causes G2/M arrest. SGTC_1919 st067113 52.3 µM -1.15322258467666 0.139590838422004 no 2917 0.124409517929821 4267 1268243 SGTC_2763 lisinopril 49.32 µM -1.15331450928654 0.13957082085819 no 2918 0.124390658442762 4137 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_413 propylparaben 100 µM -1.15639235951671 0.138901712962818 no 2919 0.123760352688372 4206 7175 A pharmaceutical preservative. SGTC_2099 5377090 177.372 µM -1.1591336691146 0.138307609024251 no 2920 0.123200851856057 4264 2243829 SGTC_3350 9150499 3.57 µM -1.15930452737907 0.13827063759613 no 2921 0.123166038491278 4253 4910996 YPR165W RHO1 SGTC_773 4358-1457 44.6 µM -1.15939830683707 0.138250347848073 no 2922 0.123146933312339 4263 1186886 SGTC_2502 avocadyne acetate 18.59 µM -1.16010613825976 0.138097269753444 no 2923 0.123002797668554 4189 3952079 SGTC_2280 7785178 200 µM -1.16032987974339 0.13804890669047 no 2924 0.122957261822198 4243 2954328 SGTC_1072 oxiconazole 14.9 nM -1.16051217017076 0.138009512062116 no 2925 0.122920170829353 4238 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3223 9129970 49.47 µM -1.16252648118429 0.137574711499942 no 2926 0.122510837241839 4260 17248386 SGTC_1920 st075728 45.7 µM -1.16288121753329 0.137498236569534 no 2927 0.122438849476217 4239 3400306 SGTC_1391 3442-0225 151 µM -1.16294090875121 0.137485371043836 no 2928 0.122426739067559 4221 5227075 SGTC_820 1582-0060 59.9 µM -1.16345969060906 0.13737359018912 no 2929 0.122321521793959 4268 3848840 SGTC_2272 7805186 180 µM -1.16386391108747 0.137286536665092 no 2930 0.122239583410501 4261 2956062 YPR165W RHO1 SGTC_1741 st038134 10.228 µM -1.16673513461315 0.136669270022181 no 2931 0.121658674691567 4308 1272587 SGTC_2826 7992541 19.48 µM -1.16954907767392 0.136066161606961 no 2932 0.121091240034951 4266 2985066 SGTC_960 1222-0186 7.7 µM -1.17001826043722 0.135965779807275 no 2933 0.120996810213003 4270 3126296 SGTC_3003 9075612 71.4286 µM -1.17076495084918 0.135806129734241 no 2934 0.120846634823032 4283 6501993 SGTC_2589 lobaric acid 100 µM -1.17166752090954 0.135613322433213 no 2935 0.120665283881007 4238 73157 A novel microtubule depolymerizer. SGTC_508 roscovitine 141 µM -1.17246881383848 0.135442307203253 no 2936 0.120504442902366 4324 160355 A CDKinase inhibitor. SGTC_2132 5317594 122.667 µM -1.17283043275589 0.135365177427096 no 2937 0.12043190575252 4211 794577 SGTC_3135 9127742 49.47 µM -1.17340353079448 0.135243002895192 no 2938 0.120317010996467 4360 3643468 SGTC_1964 st076914 61 µM -1.1741371697588 0.135086714187294 no 2939 0.120170043699701 4305 24208661 SGTC_399 oxolinic acid 75 µM -1.17493629771738 0.134916615197472 no 2940 0.120010101213591 4231 4628 A DNA gyrase inhibitor. SGTC_1627 st003713 25.6 µM -1.17547521924505 0.134801985632338 no 2941 0.119902322825635 4272 16195070 YER133W GLC7 SGTC_1060 3448-7350 82 µM -1.17551717635671 0.134793064084796 no 2942 0.119893934727966 4198 570178 SGTC_996 3970-0799 1.8 µM -1.17963067783719 0.133920356373802 no 2943 0.119073568016786 4264 6615648 YGL040C HEM2 SGTC_1135 dihydrocapsaicin 536.708 nM -1.1810752889715 0.133614795487677 no 2944 0.118786407781404 4171 107982 A Capsaicinoid. SGTC_2624 nerol 100 µM -1.18349366681694 0.133104339389567 no 2945 0.118306777503378 4182 637566 A natural product oil. SGTC_3268 9137683 49.47 µM -1.18354096406533 0.133094369581517 no 2946 0.118297410839696 4347 1953228 SGTC_1896 st058441 89 µM -1.18455795809486 0.132880121294951 no 2947 0.118096133964981 4275 688759 SGTC_983 1491-0821 12.2 µM -1.18546783804042 0.132688639911289 no 2948 0.117916261808045 4263 46495113 SGTC_208 k072-0098 12.366 µM -1.18710422334733 0.132344746209535 no 2949 0.117593256341933 4244 5948901 SGTC_426 0988-0037 14.6 µM -1.19258557451874 0.131197293203365 no 2950 0.116515859090473 4327 5383008 SGTC_1413 3910-0535 34.4 µM -1.19274435485873 0.131164157226406 no 2951 0.116484754408741 4301 2876951 SGTC_595 3909-8003 73.7 µM -1.19461309869202 0.130774602166237 no 2952 0.116119114565355 4351 699517 SGTC_3273 9137859 49.47 µM -1.19657668624295 0.13036613856469 no 2953 0.115735795993178 4374 2377234 SGTC_2261 9010538 184.68 µM -1.19723651307322 0.130229080332111 no 2954 0.115607190928694 4285 6457250 SGTC_3267 9137951 49.47 µM -1.19889756908763 0.129884489802805 no 2955 0.115283888553399 4312 16643986 SGTC_1975 st070967 30.8 µM -1.1998310641232 0.129691111067285 no 2956 0.115102478538403 4274 261391 SGTC_1556 plumbagin 1.48 µM -1.20031827150882 0.129590262557173 no 2957 0.115007878134787 4217 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_735 3076-0345 636 µM -1.20034810497462 0.129584089004619 no 2958 0.115002087207905 4342 2888990 SGTC_305 1682-2595 20.8 µM -1.20068185297657 0.129515039149007 no 2959 0.114937318046585 4290 226033 SGTC_1428 4049-0204 61.7 µM -1.20068648121728 0.129514081781377 no 2960 0.114936420044554 4325 X1428 SGTC_78 0336-0123 156.75 µM -1.20069911896405 0.129511467644631 no 2961 0.114933968010325 4120 6765896 SGTC_298 1391-0729 10 µM -1.20147284671775 0.12935149053303 no 2962 0.114783916628483 4217 3237558 SGTC_1981 st071826 47 µM -1.20319760571137 0.12899536981548 no 2963 0.114449930610493 4327 11838600 SGTC_1432 4049-0298 68.4 µM -1.20337126924411 0.128959550238894 no 2964 0.114416340407198 4312 741646 SGTC_488 nitrendipine 139 µM -1.20496125106786 0.128631923677074 no 2965 0.114109130519677 4322 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2043 5101342 149 µM -1.20617171371259 0.128382887178078 no 2966 0.113875644047769 4305 678451 SGTC_3274 9138298 49.47 µM -1.20619712011731 0.128377663739109 no 2967 0.113870747049891 4268 17015756 SGTC_717 1532-0246 73.2 µM -1.20775990962047 0.128056645101172 no 2968 0.113569813164104 4267 9561992 SGTC_615 k087-0205 167 µM -1.20782407737195 0.128043476083686 no 2969 0.113557469023714 4312 9642773 SGTC_1124 fisetin 1.16336 µM -1.20985712456763 0.127626724959431 no 2970 0.113166860916072 4308 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1287 0971-0001 34.6 µM -1.21263348649101 0.127059127516264 no 2971 0.112634990058619 4289 4665869 SGTC_2334 9017922 200 µM -1.21412306978707 0.126755323331045 no 2972 0.112350365839659 4343 3163164 SGTC_2722 naftopidil 47.16 µM -1.21421788472794 0.126736002726933 no 2973 0.112332266354493 4245 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2009 4012297 12.05 µM -1.21597538420679 0.12637824528048 no 2974 0.111997149617513 4282 45595307 SGTC_2846 9008642 19.48 µM -1.21711382100711 0.126146880410862 no 2975 0.111780456427914 4330 2992898 SGTC_3304 9125678 46.087 µM -1.21786413151555 0.125994556088925 no 2976 0.111637804312557 4230 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1857 st056007 79.3 µM -1.21954912446571 0.125652944712245 no 2977 0.111317921326438 4275 619834 SGTC_2090 5301565 104.445 µM -1.21973275648029 0.125615754691445 no 2978 0.111283099886405 4290 2056344 SGTC_122 0236-0016 402.397 µM -1.2197427140492 0.125613738257224 no 2979 0.111281211893422 4294 6808838 SGTC_2684 capsaicin 100 µM -1.21993287711667 0.125575234063719 no 2980 0.111245160652056 4329 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.22133356184003 0.125291877339537 no 2981 0.110979875508014 4338 5393153 SGTC_2558 carylophyllene oxide 100 µM -1.22266378442492 0.125023188571456 no 2982 0.110728355462832 4417 6708694 An oxygenated terpenoid and antifungal agent. SGTC_843 0310-0051 143 µM -1.23121665664731 0.123305225418025 no 2983 0.109120921631563 4336 2065037 SGTC_2768 sulfasalazine 50.2 µM -1.23184165234711 0.12318033804061 no 2984 0.109004120329818 4309 5384001 An antioxidant and salicylic acid derivative. SGTC_2792 7535235 81.82 µM -1.23368455168481 0.122812603889903 no 2985 0.108660236311334 4290 1281891 SGTC_2471 5466956 24.79 µM -1.23383262777266 0.122783090075754 no 2986 0.108632639297094 4298 724419 SGTC_3054 9094397 49.47 µM -1.23713530958286 0.122126107840383 no 2987 0.108018426480582 4308 2598354 SGTC_3352 9151559 45.5865 µM -1.23845066364735 0.121865141050395 no 2988 0.107774502425973 4320 17159339 SGTC_761 k216-0224 480 µM -1.24225965698439 0.121111645757718 no 2989 0.107070387529779 4347 1340404 SGTC_118 0083-0097 135.343 µM -1.24245050097746 0.121073979392657 no 2990 0.107035196377314 4299 5207356 SGTC_48 0382-0018 55 µM -1.24408400526336 0.120751916179239 no 2991 0.106734323557202 4369 762596 SGTC_1330 1469-0054 61.8 µM -1.24551517551258 0.120470241349727 no 2992 0.10647122038414 4321 7102664 SGTC_46 0329-0187a 2.197 µM -1.24558608698662 0.120456296996473 no 2993 0.106458196361678 4365 46494817 SGTC_1833 st055984 71 µM -1.24562740358401 0.120448172837858 no 2994 0.106450608440396 4327 676288 SGTC_1792 st045773 43.6 µM -1.24592979285663 0.120388725225935 no 2995 0.106395085599679 4277 2919270 SGTC_2653 dihydrofissinolide 100 µM -1.24685027314981 0.120207892463055 no 2996 0.106226201442269 4370 6857746 SGTC_1254 0550-0035 264 µM -1.25265011386199 0.119072887646345 no 2997 0.105166534201554 4337 15121435 SGTC_2455 5377712 9.75 µM -1.25950875946822 0.117740469416698 no 2998 0.10392331417134 4321 2243908 SGTC_572 0960-0087 17.7 µM -1.26417590091377 0.116839845606259 no 2999 0.103083449289231 4311 6796365 SGTC_1824 st053723 68.6 µM -1.2656653372328 0.116553457871931 no 3000 0.10281646162553 4350 675225 SGTC_1514 1189-1591 158 µM -1.26615033424851 0.116460310535544 no 3001 0.102729632432865 4344 767698 YMR146C TIF34 SGTC_1484 3473-2379 286 µM -1.2662565791081 0.116439912461176 no 3002 0.102710618494724 4468 671917 SGTC_34 0469-0683 81.75 µM -1.26808989565729 0.116088330992215 no 3003 0.102382924748272 4300 3690923 SGTC_2185 6113692 200 µM -1.26849131188966 0.116011450669558 no 3004 0.102311275703809 4335 874150 SGTC_2867 9039098 71.43 µM -1.26866947402427 0.115977340159101 no 3005 0.102279487115563 4321 6463460 SGTC_2136 5328288 199.296 µM -1.26882946159499 0.115946715376971 no 3006 0.102250947447235 4329 262395 SGTC_815 1582-0027 36.9 µM -1.26939139681629 0.115839195372076 no 3007 0.102150751532899 4371 3128206 SGTC_2166 5933061 31.504 µM -1.26982431113377 0.115756410368686 no 3008 0.10207360942736 4440 2877375 SGTC_2036 5160441 105 µM -1.27013015757463 0.115697949537054 no 3009 0.102019135427011 4317 134534 YIL048W NEO1 SGTC_2222 6885208 172.143 µM -1.27629775291991 0.11452352127415 no 3010 0.100925142113665 4334 609514 SGTC_1752 st044819 83.042 µM -1.2773979080062 0.114314925644508 no 3011 0.100730901485101 4304 441209 YML126C ERG13 SGTC_1046 2001-0062 216 µM -1.27894225300005 0.114022565738688 no 3012 0.100458695984033 4280 739778 SGTC_3296 9122258 64.045 µM -1.27941349934158 0.113933460270842 no 3013 0.100375741304526 4327 4730474 SGTC_1925 st057770 10.1 µM -1.27990024087466 0.113841477000886 no 3014 0.10029011146031 4345 5989122 SGTC_509 pifithrin 175 µM -1.28011449449749 0.113801004634429 no 3015 0.100252435866564 4424 4817 A p53 inhibitor. SGTC_1952 st077036 64.1 µM -1.28130194983461 0.113576881022829 no 3016 0.100043814147872 4367 2937007 SGTC_1821 st053465 65.6 µM -1.28261475598828 0.113329464844496 no 3017 0.0998135389443015 4366 675086 SGTC_823 0417-1665 178 µM -1.28420944349236 0.113029441723482 no 3018 0.0995343409184022 4364 3429856 SGTC_521 r062-0005 13.8 µM -1.28532755411955 0.112819419693488 no 3019 0.099338922684168 4276 2832033 SGTC_1267 0828-0272 9.49 µM -1.28578208515344 0.112734121857811 no 3020 0.0992595620806374 4415 745334 SGTC_1571 st070080 73.4 µM -1.28640073487615 0.112618099318967 no 3021 0.0991516210401951 4364 4315245 SGTC_1131 3454-3128 32.3 µM -1.28948719130326 0.112040534468429 no 3022 0.098614383240348 4374 710982 SGTC_171 k064-0041 9.68 µM -1.28980369029208 0.111981428324983 no 3023 0.0985594131714766 4350 53325 SGTC_120 rhodamine 6G 52.259 µM -1.29406345088552 0.11118808712265 no 3024 0.0978217524173004 4373 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1384 3089-0840 101 µM -1.29480148883285 0.111051044386017 no 3025 0.0976943591346818 4365 1069836 SGTC_2023 5144124 124 µM -1.29595056029784 0.110837919659674 no 3026 0.0974962592334656 4343 2830192 SGTC_2049 5262831 67.185 µM -1.30263101582986 0.109604661306731 no 3027 0.0963503818136075 4334 763417 SGTC_470 aa-861 153 µM -1.30291709957214 0.109552069150723 no 3028 0.096301532715316 4320 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2992 9074591 71.4286 µM -1.30616909122942 0.108955513235303 no 3029 0.0957475306928352 4323 17741321 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.30784876078944 0.108648305332779 no 3030 0.0954623058628783 4365 15053 SGTC_620 0109-0052 432 µM -1.31235688436215 0.107826860484446 no 3031 0.0946998736089647 4410 493037 SGTC_401 neomycin 50 µM -1.31577132976977 0.107207683386461 no 3032 0.0941254024230461 4362 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_614 0462-0418 107 µM -1.31926766562546 0.106576317173603 no 3033 0.0935398218258362 4150 5188303 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.32083257952538 0.10629459716369 no 3034 0.0932785969930147 4423 91467 include heat shock SGTC_325 2810-4341 181 µM -1.32092656776636 0.106277694284858 no 3035 0.0932629250864049 4377 774970 SGTC_1497 4476-2978 41.3 µM -1.32111747081793 0.106243368187996 no 3036 0.0932310992763999 4426 1528379 SGTC_121 0557-0495 61.343 µM -1.32365737642125 0.105787431997069 no 3037 0.0928084301718196 4438 3104427 SGTC_2802 7925815 54.55 µM -1.32448349991061 0.105639440577301 no 3038 0.0926712596974424 4358 1262923 SGTC_1143 3454-2408 5.08 µM -1.32602273180527 0.105364102616007 no 3039 0.0924160839707288 4395 X1143 SGTC_591 4299-0174 154 µM -1.32768585285574 0.105067187259196 no 3040 0.0921409545342953 4423 5509088 SGTC_1628 st004252 77.7 µM -1.32914273301841 0.104807589886069 no 3041 0.0919004420925516 4401 692968 SGTC_719 2810-4230 27.3 µM -1.32914859315048 0.104806546624336 no 3042 0.0918994755988433 4400 721079 SGTC_2492 derrusnin 100 µM -1.3350358156803 0.103762257165133 no 3043 0.0909323122802479 4426 1715307 Part of coumarin class of compounds. SGTC_108 0509-0257 621.132 µM -1.33540074056478 0.10369777526652 no 3044 0.0908726112616324 4333 536624 SGTC_378 3970-0959 8.33 µM -1.3357882348977 0.103629337197467 no 3045 0.0908092497643974 4404 6615653 SGTC_752 1896-0090 130 µM -1.33633369765689 0.103533054773283 no 3046 0.0907201134734342 4387 772567 SGTC_2516 gossypol 71.55 µM -1.34257626601709 0.102435767301373 no 3047 0.0897046098948813 4413 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2758 dehydroepiandrosterone 69.35 µM -1.34437712142352 0.102120799176805 no 3048 0.0894132341018386 4387 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2762 leflunomide 42.06 µM -1.34525174903103 0.101968081977245 no 3049 0.0892719748645939 4375 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_191 3914-0123 66.505 µM -1.34759484386236 0.101559777436217 no 3050 0.0888943649396746 4429 3144412 SGTC_369 0957-0393 4.5 µM -1.34915771803929 0.101288095846281 no 3051 0.0886431562369192 4399 6997992 SGTC_2499 avocadenofuran 51.48 µM -1.34955831694444 0.101218543237048 no 3052 0.0885788511569178 4358 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1609 st001574 46.4 µM -1.35091887289679 0.10098258120899 no 3053 0.0883607109335718 4394 3960012 SGTC_3053 9095903 49.47 µM -1.35196039770882 0.100802220105343 no 3054 0.08819399221974 4515 17174018 SGTC_1516 st013856 110 µM -1.35964894199824 0.0994780562152259 no 3055 0.0869705212867191 4435 5281404 A mutagen and neurotoxin. SGTC_3092 9117248 49.47 µM -1.36010944795838 0.0993991507828465 no 3056 0.0868976458556243 4529 17141857 SGTC_1433 4060-0023 7.6 µM -1.36110232081363 0.0992291825798941 no 3057 0.086740678174686 4428 3840627 SGTC_3258 9138477 49.47 µM -1.36469928078896 0.0986152047854414 no 3058 0.0861737928981817 4440 4970355 SGTC_713 1488-1073 324 µM -1.3650425073298 0.0985567638939025 no 3059 0.0861198451533164 4445 3312542 SGTC_2854 9024559 71.43 µM -1.36594765539043 0.0984027667068404 no 3060 0.0859776967478287 4421 3163529 SGTC_1682 st012968 530 nM -1.37372683730232 0.0970865163614416 no 3061 0.0847632509782933 4404 24207270 SGTC_1218 1348-1416 30.7 µM -1.374109930551 0.0970220318337981 no 3062 0.0847037784772697 4383 6787668 SGTC_1016 4226-1401 38 µM -1.37672734140773 0.0965822947420488 no 3063 0.0842982811044068 4420 2901613 SGTC_2138 5575593 77.673 µM -1.3767392349306 0.0965802999224668 no 3064 0.0842964418539119 4432 762213 SGTC_2606 farnesol 9.78 µM -1.37889407261766 0.0962193829895276 no 3065 0.0839637079925309 4422 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2438 5259590 200 µM -1.37921997429769 0.096164883661791 no 3066 0.0839134706776592 4429 1201127 SGTC_1777 st045864 34.765 µM -1.37972355134958 0.0960807169697063 no 3067 0.0838358893296859 4410 4691462 SGTC_1152 3909-8331 15.9 µM -1.38025990330491 0.095991131935193 no 3068 0.0837533179215152 4391 16001939 SGTC_3188 9110789 49.47 µM -1.38061589585996 0.0959317056386672 no 3069 0.0836985465909536 4403 849217 SGTC_511 blebbistatin 171 µM -1.38135050184119 0.0958091624454005 no 3070 0.0835856086508811 4479 3476986 A myosin inhibitor. SGTC_2058 5236698 133 µM -1.38444289917024 0.0952945671381713 no 3071 0.0831114404599497 4390 766665 SGTC_145 3737-0113 38.366 µM -1.38716775726723 0.0948428218241786 no 3072 0.0826953073524905 4396 6849351 SGTC_1852 st056254 31.4 µM -1.38974045302227 0.0944177530843989 no 3073 0.0823038530119383 4386 442583 SGTC_655 k060-0012 42 µM -1.39031363011788 0.0943232426396871 no 3074 0.0822168303446933 4410 5994525 SGTC_1191 1487-1166 10.6 µM -1.39152750293227 0.0941233190657211 no 3075 0.0820327628124428 4459 3955771 SGTC_3134 9127454 49.47 µM -1.39442806924929 0.0936468651888087 no 3076 0.081594188389605 4476 24262820 SGTC_2957 9076800 11.52 µM -1.39594356209985 0.0933986361663778 no 3077 0.0813657455997894 4412 16459615 SGTC_1676 st018489 23.4 µM -1.39857372106743 0.092968985553252 no 3078 0.0809704256435355 4430 3696235 SGTC_1648 st011736 69.8 µM -1.39950315712768 0.0928175070896206 no 3079 0.0808310761332548 4420 2855514 SGTC_1262 0737-0114 49.6 µM -1.40143688388821 0.092502935417305 no 3080 0.080541734572496 4462 765919 SGTC_252 miconazole 1.30953 nM -1.40370154852173 0.0921355315978472 no 3081 0.0802038705775659 4338 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.40707533984089 0.091590195750181 no 3082 0.0797025248183273 4445 6708561 SGTC_1578 josamycin 24.2 µM -1.40953085722503 0.091194795165142 no 3083 0.079339127902005 4428 5282165 A P450 substrate. SGTC_3046 9092212 49.47 µM -1.41270121109186 0.0906861617403629 no 3084 0.0788717976705269 4512 25236637 SGTC_1342 1486-1464 234 µM -1.41318409433748 0.0906088758468849 no 3085 0.078800801005571 4454 3253938 SGTC_2373 9071805 200 µM -1.41339625167912 0.0905749353387465 no 3086 0.0787696235551988 4449 10149009 SGTC_3298 9116858 71.43 µM -1.41660356781956 0.090062984537566 no 3087 0.0782994324131894 4507 2506942 SGTC_538 2922-0838 53.3 µM -1.41682854720217 0.0900271542578442 no 3088 0.0782665305910547 4463 777039 SGTC_160 3453-0671 289.699 µM -1.41742758491808 0.0899318029906634 no 3089 0.0781789762128981 4457 5322268 SGTC_1688 st021091 57.6 µM -1.41766340036995 0.0898942878817189 no 3090 0.0781445301959376 4467 3656366 SGTC_351 caspofungin 25 nM -1.41986184731171 0.0895451036470473 no 3091 0.0778239525750607 4435 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2465 5809242 33.21 µM -1.42120928918581 0.0893315855953922 no 3092 0.0776279624924115 4508 2731748 SGTC_2202 7226349 200 µM -1.42165463182194 0.0892610991485858 no 3093 0.0775632683268408 4434 844334 SGTC_1141 3253-0389 52.6 µM -1.42213092040321 0.0891857605458143 no 3094 0.0774941240094466 4431 5402031 SGTC_1691 st019933 84.6 µM -1.42287405501232 0.0890683071683272 no 3095 0.0773863343182839 4430 6176082 SGTC_881 0833-0569 170 µM -1.43364831720203 0.087378334242741 no 3096 0.075836323906406 4478 5418700 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.43421118076973 0.0872907099646306 no 3097 0.0757560036790877 4402 97141 SGTC_962 1254-0300 21.5 µM -1.44784463517597 0.0851883001590849 no 3098 0.0738302532145951 4440 7340576 SGTC_1240 0356-0016 42.1 µM -1.45150892969152 0.0846297531523526 no 3099 0.0733190987621753 4430 4305613 SGTC_764 1951-2361 146 µM -1.45752887359562 0.0837181052887394 no 3100 0.072485223559772 4473 5438930 SGTC_2359 9039622 200 µM -1.45890050839145 0.0835114235164814 no 3101 0.0722962466000058 4436 6463596 SGTC_1199 1638-0010 4.46 µM -1.46132581331297 0.083146910577394 no 3102 0.0719630245584369 4477 3111136 SGTC_838 0109-0203 71.4 µM -1.4617525887681 0.0830828920310401 no 3103 0.0719045102644503 4491 759422 SGTC_691 1548-0686 185 µM -1.46228872097723 0.0830025219437265 no 3104 0.0718310540084738 4441 46495133 SGTC_947 3447-0010 211 µM -1.46240619176914 0.0829849200369549 no 3105 0.0718149668531264 4432 748350 SGTC_2372 9071633 200 µM -1.46275344063619 0.0829329044374856 no 3106 0.0717674286657833 4510 21321366 SGTC_2721 ifenprodil 61.44 µM -1.46690994126103 0.0823121904635646 no 3107 0.0712002779089519 4473 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2723 salbutamol 83.58 µM -1.47530872569316 0.0810686387220599 no 3108 0.0700647807985066 4479 9884233 β2-adrenoceptor agonist SGTC_2387 9077560 195.08 µM -1.47834060761816 0.0806232284475866 no 3109 0.0696583168757353 4485 5303272 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.48101437899999 0.0802319636972314 no 3110 0.0693013709376732 4497 5024745 SGTC_924 2046-0044 21.3 µM -1.48235765407399 0.0800359387374982 no 3111 0.0691225775595472 4463 3623589 SGTC_570 0987-0065 62.6 µM -1.48250302203973 0.0800147468326708 no 3112 0.0691032500424474 4337 3104428 SGTC_2224 6650123 117.647 µM -1.48781593335875 0.0792431324356029 no 3113 0.0683997212643591 4519 2908370 SGTC_71 0417-1750 47.813 µM -1.48936762226798 0.0790188410731734 no 3114 0.0681952948489545 4447 6811472 SGTC_3154 9100113 49.47 µM -1.48958465103579 0.0789875086679847 no 3115 0.0681667401415976 4473 25237525 SGTC_2253 7938677 135.83 µM -1.48967735542769 0.078974127819799 no 3116 0.0681545457388724 4536 2301972 SGTC_963 1269-2853 151 µM -1.49289067090018 0.0785113819186724 no 3117 0.0677329037737813 4479 3668223 SGTC_2529 gangaleoidin 93.61 µM -1.49588048009463 0.0780826715615808 no 3118 0.0673424019452682 4484 4565183 SGTC_2225 6654152 15.4 µM -1.49643414010944 0.0780034772040367 no 3119 0.0672702792376398 4428 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1278 0874-0585 172 µM -1.49694906115528 0.0779298786958342 no 3120 0.0672032564827705 4536 766306 SGTC_1303 1160-0052 261 µM -1.49898484891433 0.0776394161476408 no 3121 0.066938781328927 4442 3562476 SGTC_2344 7990960 76.95 µM -1.49966504891458 0.0775425498451847 no 3122 0.0668505942272725 4473 140813 SGTC_2487 5918373 44.05 µM -1.50780780813751 0.0763900657424592 no 3123 0.0658018615917439 4554 2876279 SGTC_2418 pentamidine 31.67 µM -1.50859059459205 0.076279964507661 no 3124 0.0657017196081058 4444 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3333 9141820 12.094 µM -1.50919816653532 0.0761945909873549 no 3125 0.0656240743132176 4486 1939433 SGTC_146 3448-8650 53.125 µM -1.51172391854728 0.0758404620883136 no 3126 0.065302055602783 4475 2891488 YIL048W NEO1 SGTC_3161 9100388 49.47 µM -1.5117643338156 0.0758348057787414 no 3127 0.065296912873344 4577 25236368 SGTC_1603 st002045 67.8 µM -1.51295473109141 0.0756683480609236 no 3128 0.0651455790358678 4492 5887985 SGTC_322 k048-0136 19.3 µM -1.51403605224798 0.0755173842583465 no 3129 0.065008347952472 4549 6823282 SGTC_2618 avocadyne 43.43 µM -1.5152727864464 0.0753450046403554 no 3130 0.0648516684994756 4429 3015189 SGTC_2715 st079500 56.4 µM -1.51809996927588 0.0749520703442398 no 3131 0.0644945994626023 4493 28246688 SGTC_3022 9087993 49.47 µM -1.5208108090549 0.074576775684157 no 3132 0.0641536605650643 4583 17173644 SGTC_1394 3474-0001 65.7 µM -1.52121308050816 0.0745212067598913 no 3133 0.0641031869904092 4483 5017666 YIL048W NEO1 SGTC_2814 7977482 42.97 µM -1.52594338300067 0.0738701417352772 no 3134 0.0635119825881783 4501 6456762 SGTC_2947 9072639 7.68 µM -1.52675698516525 0.0737585993669252 no 3135 0.0634107257170705 4449 16488146 SGTC_2874 9043904 71.43 µM -1.52708450696988 0.0737137334899936 no 3136 0.0633699994762527 4439 4463428 SGTC_775 4577-0580 57.3 µM -1.52776933398337 0.0736199892467673 no 3137 0.0632849093277186 4532 2006902 SGTC_1756 st041558 35.5 µM -1.53103014266588 0.0731748751802213 no 3138 0.0628809715760864 4582 3955792 SGTC_1880 MG-132 525 µM -1.53190068149446 0.0730563919264259 no 3139 0.0627734726649861 4470 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1547 harmine 94.2 µM -1.53319281790331 0.0728807985937365 no 3140 0.0626141766741871 4418 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2938 9059746 27.26 µM -1.53395062737814 0.0727779673916611 no 3141 0.0625208997837276 4503 6471769 SGTC_3169 9102970 49.47 µM -1.54212963720154 0.0716751729883046 no 3142 0.0615210471292571 4588 17027839 SGTC_197 4544-0043 41.561 µM -1.54579917547891 0.0711845863467959 no 3143 0.0610765381203134 4538 896523 SGTC_2872 9044037 25.97 µM -1.54634426368307 0.0711119330607664 no 3144 0.0610107236171394 4569 6465195 SGTC_1107 amlodipine 47 µM -1.54818331726349 0.0708672308379732 no 3145 0.0607890834042769 4110 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_420 mitomycin C 81.9 mM -1.54867763018365 0.0708015685948345 no 3146 0.0607296169848818 4501 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2059 5238311 157 µM -1.55066329949257 0.0705382724131409 no 3147 0.0604911970045324 4483 703021 SGTC_2930 9013230 14.89 µM -1.55146296783074 0.0704324506614888 no 3148 0.0603953876672762 4497 2995857 SGTC_1084 voriconazole 435 nM -1.55225664351165 0.0703275426564885 no 3149 0.0603004137792435 4544 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_587 k089-0003 57 µM -1.55374254511991 0.0701314593753513 no 3150 0.0601229201463388 4442 9659696 SGTC_849 0386-0493 241 µM -1.55540552248965 0.0699125077324066 no 3151 0.059924759848589 4549 726119 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.56693356699207 0.0684091325238189 no 3152 0.0585651103150826 4469 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3037 9091026 49.47 µM -1.57640197494035 0.0671931138931819 no 3153 0.0574665967681 4409 25236398 YIL048W NEO1 SGTC_2321 7390090 138.78 µM -1.57695948704736 0.067122037536007 no 3154 0.0574024236345858 4536 649046 SGTC_1973 st070275 50.2 µM -1.58048527101302 0.066673886499725 no 3155 0.0569978886760296 4511 17118334 SGTC_187 1488-2104 32.728 µM -1.58484057479206 0.0661234989254849 no 3156 0.0565012805018034 4530 2852859 SGTC_2170 morpholine 200 µM -1.58869664284681 0.0656391440905448 no 3157 0.0560644486236748 4573 121171 Reacts with secondary amines. SGTC_1087 pterostilbene 9.05 µM -1.59006599073832 0.0654678057959148 no 3158 0.0559099654758448 4540 5281727 Similar to reservatol, lowers cholesterol. SGTC_2893 9048488 25.97 µM -1.59147664677062 0.0652916617849389 no 3159 0.055751173495534 4568 6467338 SGTC_805 3852-0218 479 µM -1.59205838462883 0.0652191292421177 no 3160 0.0556857932924684 4526 6615355 SGTC_1554 st069299 38.7 µM -1.59556400336108 0.0647833626372582 no 3161 0.0552930848315798 4493 24207999 SGTC_2478 5763493 32.33 µM -1.59557452403866 0.0647820582735126 no 3162 0.0552919095785797 4492 1365576 YLR208W SEC13 SGTC_1055 3448-0672 86 µM -1.59817703849281 0.0644600220291495 no 3163 0.0550017911748858 4508 748378 SGTC_836 0330-0104 1.35 µM -1.60188790551383 0.0640029905802626 no 3164 0.0545901997241685 4588 46494820 SGTC_2694 st077685 81.9 µM -1.60473400661107 0.0636541743647894 no 3165 0.0542761773349626 4480 2838096 SGTC_1632 st005650 90 µM -1.60477146395174 0.063649593499633 no 3166 0.0542720540568748 4570 2759605 SGTC_3006 9075424 71.4286 µM -1.60684533098408 0.0633963688431679 no 3167 0.0540441506876242 4511 7465181 SGTC_2227 7312221 64.1025 µM -1.61133888061662 0.0628503854057726 no 3168 0.0535529403934584 4650 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_868 0527-0199 213 µM -1.61270717345717 0.0626848622886429 no 3169 0.0534040706659247 4555 2849450 SGTC_1056 3448-1962 115 µM -1.61323978825301 0.0626205235310373 no 3170 0.0533462111337437 4512 715507 SGTC_275 trichlorophene 5.69 µM -1.61535184634348 0.0623658979584132 no 3171 0.053117260954541 4580 62616 SGTC_1502 4534-4282 27.7 µM -1.6163278276013 0.0622485086598887 no 3172 0.0530117266855714 4544 3278949 SGTC_2484 5809818 12.04 µM -1.61797305944156 0.06205101330345 no 3173 0.0528342018602561 4530 2870548 SGTC_548 1436-0017 110 µM -1.61829343830177 0.0620126116225505 no 3174 0.0527996870642514 4581 9677137 SGTC_2228 7354201 200 µM -1.62261309840395 0.0614966515087801 no 3175 0.0523360693451029 4653 753451 SGTC_2677 mitomycin C 100 µM -1.6246047610769 0.0612598903104871 no 3176 0.0521234010096164 4633 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1887 st057648 70.8 µM -1.63457775567498 0.0600850352602603 no 3177 0.0510687969549921 4545 688672 SGTC_2300 7976697 71.57 µM -1.6403299114016 0.0594154763063922 no 3178 0.0504682948009148 4457 2236109 SGTC_1782 st039423 80.636 µM -1.64161183763292 0.0592670583176047 no 3179 0.0503352364219959 4575 2068169 SGTC_872 0588-0139 234 µM -1.64297279619394 0.0591098084913528 no 3180 0.0501942809378282 4530 2047100 SGTC_222 nsc-310342 10.666 µM -1.64301296567411 0.0591051721485234 no 3181 0.0501901253405337 4584 432556 SGTC_189 3970-0742 2.116 µM -1.64364218630202 0.0590325850164886 no 3182 0.0501250672423528 4540 2891807 SGTC_3353 9151644 39.2805 µM -1.65087648287095 0.0582030490487599 no 3183 0.0493818993730044 4577 4909158 SGTC_51 1013-0126 23.419 µM -1.65263755841488 0.058002504126196 no 3184 0.0492023247105257 4551 1627850 SGTC_96 0929-0093 37.281 µM -1.65379075559334 0.0578714767074886 no 3185 0.0490850174609546 4572 6991579 SGTC_2218 6965428 192.983 µM -1.66665312186649 0.0564257633396693 no 3186 0.0477916996859903 4489 675684 SGTC_1816 st051957 91.6 µM -1.66722626106145 0.0563620117632387 no 3187 0.047734711377419 4586 674121 SGTC_1655 st012546 55.1 µM -1.66739684419687 0.0563430483807407 no 3188 0.047717760487453 4568 720985 YLR208W SEC13 SGTC_3172 9105863 49.47 µM -1.66864379188574 0.0562045804397678 no 3189 0.0475939973339439 4679 2348785 SGTC_1993 st073995 70.8 µM -1.66868918670679 0.0561995446149693 no 3190 0.0475894966221288 4580 3098394 SGTC_2490 carminic acid 95.39 µM -1.66989260910049 0.0560661739499827 no 3191 0.0474703064509122 4571 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3000 9075062 71.4286 µM -1.67674126871477 0.0553119098771945 no 3192 0.0467965434415547 4564 17057871 SGTC_689 0833-0039 98 µM -1.67955265545164 0.0550046126977474 no 3193 0.0465221929121962 4547 5374726 SGTC_1826 st055655 41.6 µM -1.68046162830784 0.0549055469909883 no 3194 0.0464337670254109 4571 676168 SGTC_1423 4048-0112 5.59 µM -1.68403495878683 0.0545174685629174 no 3195 0.0460874564022975 4626 X1423 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.68512728735781 0.0543992710887768 no 3196 0.0459820079976008 4611 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2388 9080168 200 µM -1.68743657305814 0.054150057787313 no 3197 0.0457597181750515 4608 15943073 SGTC_1883 5-benzylidenerhodanine 20 µM -1.69192474112295 0.0536682891773379 no 3198 0.0453301619863569 4568 1273210 SGTC_1700 st030840 7.9285 µM -1.69680805938472 0.0531479676586398 no 3199 0.0448664772767887 4629 5499307 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.69768748706933 0.0530546903278924 no 3200 0.0447833803380386 4544 6857784 SGTC_628 1636-0253 16 µM -1.69905333512575 0.052910077786568 no 3201 0.0446545673834025 4582 4456143 SGTC_1798 st045719 60.953 µM -1.70286572485443 0.0525080854698737 no 3202 0.0442965997943643 4571 3980186 SGTC_1753 st043925 64 µM -1.71128095566754 0.0516293349008534 no 3203 0.0435146301239584 4609 670181 SGTC_359 0081-0058 15.9 µM -1.71278291739908 0.0514737310290242 no 3204 0.0433762419866923 4576 3494159 SGTC_665 3914-0008 307 µM -1.71317214676521 0.0514334676103651 no 3205 0.0433404371042092 4569 1069549 SGTC_2824 7998404 51.95 µM -1.71559863813736 0.0511830263094842 no 3206 0.0431177639725705 4570 837851 SGTC_3146 9095609 49.47 µM -1.72035721950852 0.0506947048927813 no 3207 0.0426837641620263 4628 17173999 SGTC_771 0250-0039 27.3 µM -1.73082493631315 0.0496335754758062 no 3208 0.0417414964574983 4549 3005115 SGTC_1157 4092-0394 27.6 µM -1.73136053048777 0.0495797617032688 no 3209 0.0416937408162041 4639 3659885 SGTC_1416 3966-0321 25.3 µM -1.75169757971529 0.0475706243333187 no 3210 0.0399129116453893 4664 582530 YLR208W SEC13 SGTC_1842 st055362 61.2 µM -1.7529236478789 0.0474516140680664 no 3211 0.0398075569123335 4580 676032 SGTC_1503 4585-0012 61.3 µM -1.76866683843742 0.04594457540904 no 3212 0.0384747447212888 4633 2922052 SGTC_852 0418-0143 439 µM -1.7716711623961 0.0456613994258271 no 3213 0.0382245796528706 4596 5369229 SGTC_827 3253-0474 693 µM -1.77926727481408 0.0449516748806128 no 3214 0.0375979767321887 4630 5402065 SGTC_3309 9129340 25.759 µM -1.78159410037041 0.0447360589533684 no 3215 0.0374077236047676 4595 17158987 SGTC_630 4356-0227 183 µM -1.78890803403307 0.0440637299632652 no 3216 0.0368148138614307 4578 779312 SGTC_2552 juarezic acid 87.02 µM -1.79268681362186 0.0437195734171085 no 3217 0.0365115080880772 4583 1549512 SGTC_714 4296-0578 26.1 µM -1.79662000687788 0.0433636603772889 no 3218 0.0361979830023666 4657 1589775 SGTC_2818 7996756 12.99 µM -1.80150444682479 0.0429249298159913 no 3219 0.0358117035209809 4641 2241621 SGTC_1859 st055998 20 µM -1.80646222603247 0.0424832868781243 no 3220 0.0354230846817199 4564 676301 SGTC_2291 7917025 104.35 µM -1.80982080606148 0.0421861952526076 no 3221 0.0351617901577073 4532 2964612 SGTC_1661 st013063 9.66 µM -1.81399795845029 0.0418190429506619 no 3222 0.0348390200372356 4678 721395 SGTC_585 0kpi-0023 191 µM -1.81680237394854 0.0415740027634269 no 3223 0.0346236896022753 4577 64601 SGTC_834 0312-0008 75.7 µM -1.83109305887827 0.0403433403234278 no 3224 0.0335433271905896 4663 6385573 YIL048W NEO1 SGTC_2247 cerulenin 830 nM -1.83251165171526 0.040222807403223 no 3225 0.0334376137091332 4643 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1929 genistein trimethyl ether 50.5 µM -1.83318861211209 0.0401653916107421 no 3226 0.0333872634139391 4593 136420 SGTC_326 k292-0812 17.5 µM -1.84241645735789 0.0393893595579521 no 3227 0.0327071281655876 4642 3579357 SGTC_172 1112-0046 2.638 µM -1.84349141111613 0.0392997580941839 no 3228 0.0326286472953098 4629 2802135 YIL048W NEO1 SGTC_2310 7668677 200 µM -1.84549394900236 0.0391332812989458 no 3229 0.032482858955427 4598 2197143 SGTC_1569 carminic acid 40.6 µM -1.84834834512107 0.038896979775327 no 3230 0.032275983074119 4683 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1429 4049-0205 9.46 µM -1.85259646862887 0.0385474512270827 no 3231 0.0319701094993537 4684 22774478 SGTC_2799 7812892 81.82 µM -1.86182537568509 0.0377969300477885 no 3232 0.0313138542174999 4643 20205235 SGTC_3008 9078912 71.4286 µM -1.86658380032776 0.0374146461609093 no 3233 0.0309798657833418 4647 16648731 SGTC_2534 helenine 20.12 µM -1.86885580343114 0.0372332343028215 no 3234 0.0308214393221196 4650 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3036 9090181 49.47 µM -1.87081230934942 0.0370775903459391 no 3235 0.0306855504231816 4699 25236586 SGTC_2943 9068529 45.32 µM -1.89858924257477 0.0349246969845525 no 3236 0.0288092519555022 4607 3270634 SGTC_2427 5545055 42.75 µM -1.90433354648591 0.0344925329951285 no 3237 0.0284333789390844 4611 5372858 SGTC_1643 st009866 20.2 µM -1.90648377091316 0.0343318983944053 no 3238 0.0282937346501937 4649 3156273 YOR207C RET1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.91469929786792 0.0337238019621614 no 3239 0.0277654315943045 4614 6708514 SGTC_2652 actinonin 100 µM -1.9160470005857 0.0336248990680749 no 3240 0.0276795567231853 4715 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_213 1246-0773 967 nM -1.9270788845204 0.0328242531528346 no 3241 0.0269848998977919 4681 6251622 SGTC_368 fentichlor 4.58 µM -1.92743098836977 0.0327989600683868 no 3242 0.0269629704179204 4657 7329 A pesticide. SGTC_94 0334-0113 514.748 µM -1.93913963482308 0.031966987332438 no 3243 0.0262421688243089 4668 6795178 SGTC_638 3970-0837 4.09 µM -1.9394973561874 0.0319418459137681 no 3244 0.0262204030720017 4673 4118451 YLR208W SEC13 SGTC_645 0845-0943 5.41 µM -1.94759996924996 0.0313767371583071 no 3245 0.0257314237261332 4689 1885106 SGTC_2026 5148700 152 µM -1.95767749473211 0.0306854502739672 no 3246 0.0251339338237523 4670 79838 SGTC_2974 9094440 9.66 µM -1.96722258996184 0.0300423630708699 no 3247 0.0245787773997067 4643 25236134 SGTC_1813 st051246 8.6015 µM -1.96912409640791 0.0299155959634957 no 3248 0.0244694211976852 4656 5291959 SGTC_2098 5376439 882.5 nM -1.97276678907183 0.029673988725179 no 3249 0.0242610692882215 4698 2844116 SGTC_2793 7325131 81.82 µM -1.97461318246814 0.0295521435487683 no 3250 0.0241560309617138 4631 4176441 SGTC_1466 k213-0079 57.5 µM -1.9825443289375 0.0290334736470133 no 3251 0.0237091755681803 4684 3657981 SGTC_2120 5538279 151.968 µM -1.98388762158457 0.0289463804230591 no 3252 0.0236341845789043 4693 2058197 SGTC_2975 9084847 53.72 µM -1.98658263375028 0.0287723023681359 no 3253 0.0234843336341631 4651 27211724 SGTC_82 0054-0107 293.755 µM -2.01323333668435 0.0270972691193902 no 3254 0.0220450438517636 4669 3104697 SGTC_2419 paclitaxel 166.5 µM -2.02364887944934 0.0264651360340291 no 3255 0.0215031459693698 4637 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_921 1561-0023 372 µM -2.02680050201763 0.0262763059461001 no 3256 0.0213414095568839 4675 24050882 SGTC_2173 5763948 167 µM -2.030536247256 0.0260539381505543 no 3257 0.0211510302950835 4676 2867177 SGTC_1195 1502-0147 41.1 µM -2.03111128334247 0.0260198496873944 no 3258 0.0211218535577562 4704 817940 SGTC_1822 st052468 42 µM -2.03487924301123 0.0257974048649168 no 3259 0.0209315125231554 4705 2873678 SGTC_257 daunorubicin 18.5 µM -2.0355653935318 0.0257570691430344 no 3260 0.0208970078900667 4714 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_560 2332-1943 155 µM -2.04557751980804 0.0251744807918743 no 3261 0.0203989775436252 4693 21177716 SGTC_323 4013-0906 34.3 µM -2.05889940827838 0.0244164619072454 no 3262 0.0197519378969646 4716 2910086 SGTC_2368 9071271 200 µM -2.06349514082688 0.0241594489908324 no 3263 0.0195328044988177 4686 27209959 SGTC_660 4031-1742 102 µM -2.07270491902103 0.0236512355054736 no 3264 0.0190998748559355 4602 6738706 SGTC_586 0957-0265 8.15 µM -2.08229029667099 0.0231318740984808 no 3265 0.018657980844203 4638 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2299 7976368 114.88 µM -2.08340636457285 0.0230720314453436 no 3266 0.0186070993115783 4687 2979718 SGTC_3057 9095946 49.47 µM -2.08988468288762 0.0227272382699942 no 3267 0.0183140799177018 4734 24540043 SGTC_1193 1488-0126 41.5 µM -2.09849602359257 0.0222756515305586 no 3268 0.0179306754014519 4689 1384710 SGTC_2155 5570423 76 µM -2.10004947925163 0.0221949982097354 no 3269 0.0178622444004649 4707 797402 SGTC_1057 3448-5381 134 µM -2.11263425137577 0.0215506537375831 no 3270 0.0173160423741575 4695 5497911 SGTC_3035 9091303 49.47 µM -2.12286700496108 0.0210384532306722 no 3271 0.0168824990205321 4738 25237002 SGTC_2181 6316240 54.2555 µM -2.12286711444157 0.0210384478062202 no 3272 0.0168824944321589 4716 12779990 SGTC_2414 st077232 92.9 µM -2.12341944971755 0.021011096198886 no 3273 0.0168593593989181 4656 729801 SGTC_1442 4112-3290 3 µM -2.13247505242878 0.020566936836598 no 3274 0.0164839066232558 4746 704353 SGTC_226 1,3-diallylurea 8.28947 mM -2.14637269185125 0.0199007682022232 no 3275 0.0159216281222213 4709 74537 YKL182W FAS1 SGTC_1944 st076371 56.9 µM -2.15534665688147 0.019480411887678 no 3276 0.015567358646373 4701 24208455 SGTC_851 0394-0702 453 µM -2.15574428955193 0.0194619619056121 no 3277 0.0155518188850205 4719 762646 SGTC_1617 st002906 78 µM -2.15681439154005 0.0194123833524843 no 3278 0.0155100646625747 4710 5150859 SGTC_1722 st034304 3.6505 µM -2.16278625840768 0.0191376687504966 no 3279 0.0152788114990915 4657 4036148 YLR033W RSC58 SGTC_2069 5228469 200 µM -2.17363051882685 0.0186472636728446 no 3280 0.014866447266303 4707 2835210 SGTC_1439 4092-1168 46 µM -2.18574240915404 0.0181122190282281 no 3281 0.0144172281517215 4733 2886240 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -2.1933122534226 0.0177845093917625 no 3282 0.0141424447019172 4750 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2409 alverine citrate 63.97 µM -2.20575895787107 0.0172566706872272 no 3283 0.0137004406875994 4683 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_235 0330-0087 5 mM -2.20902280202958 0.017120493354421 no 3284 0.0135865274703123 4746 46494818 YHR062C RPP1 SGTC_1921 5740136 50 µM -2.21429327934731 0.0169025322855388 no 3285 0.0134043053222751 4675 1774243 SGTC_597 k018-0003 82.8 µM -2.21504883229098 0.0168714816155821 no 3286 0.013378356467573 4755 6786234 SGTC_1928 4'-methoxychalcone 40.3 µM -2.21834384010126 0.0167366375446664 no 3287 0.0132656985745609 4712 641818 SGTC_1335 1486-0900 202 µM -2.21835353876614 0.0167362420038177 no 3288 0.0132653681859643 4723 X1335 SGTC_2507 purpurin 79.67 µM -2.22994313109501 0.0162692620747979 no 3289 0.0128756092602218 4706 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1512 0259-0544 12.2 µM -2.23113638750712 0.0162218220082662 no 3290 0.0128360480450587 4705 18476 SGTC_129 0088-0017 176.636 µM -2.23227167691299 0.0161767965822624 no 3291 0.0127985063149401 4620 182446 SGTC_324 1315-0088 19.6 µM -2.24411122274398 0.0157135877929839 no 3292 0.0124126230311046 4739 6787421 SGTC_1274 0865-0114 173 µM -2.24447080549808 0.0156996994184708 no 3293 0.0124010626393281 4740 870624 SGTC_1672 st016598 6.51 µM -2.25468487784647 0.0153095699940447 no 3294 0.0120765577590185 4705 4665860 YNL267W PIK1 SGTC_1729 st035615 45.989 µM -2.25546907813772 0.0152799644081343 no 3295 0.0120519505378229 4705 17385451 SGTC_2568 diosmetin 100 µM -2.27250641772086 0.0146487937792233 no 3296 0.0115279704084241 4733 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_132 0417-1715 25.805 µM -2.27511991651316 0.0145539854631218 no 3297 0.0114493686060446 4711 6769098 SGTC_2950 9072895 21.46 µM -2.27764438998754 0.0144629085548657 no 3298 0.0113738867342751 4676 17332245 SGTC_2160 5660466 132.927 µM -2.28887519433387 0.0140636509174483 no 3299 0.0110433024524292 4728 2859134 SGTC_2007 4011539 71.82 µM -2.29031534424358 0.0140131468736242 no 3300 0.0110015214781159 4724 45595301 SGTC_1622 st003707 19.4 µM -2.31346991751538 0.0132223575475156 no 3301 0.0103484084282462 4744 10140899 SGTC_92 0063-0024 660.874 µM -2.32054724374188 0.0129884733963817 no 3302 0.0101556461585645 4776 3594437 SGTC_2754 granisetron 64.02 µM -2.33616102156092 0.0124851031888738 no 3303 0.00974142547256437 4714 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2294 7971431 200 µM -2.34408494833622 0.0122361696187454 no 3304 0.00953691328884031 4732 5741572 SGTC_647 0140-0236 81 µM -2.34840300541271 0.012102335194364 no 3305 0.00942705454470297 4755 990837 SGTC_170 4197-0004 226 µM -2.35356677455038 0.0119439564189282 no 3306 0.00929713393557066 4727 218692 SGTC_2305 7443522 69.23 µM -2.36412412655088 0.0116257369214091 no 3307 0.00903637809276787 4691 5415886 SGTC_1735 st034310 56.75 µM -2.36486306705055 0.011603742022462 no 3308 0.00901836923041543 4729 871153 SGTC_162 k030-0015 37.8 µM -2.38003403324712 0.0111600903409353 no 3309 0.0086555195833845 4750 1809920 YMR134W ERG29 SGTC_649 1123-0311 367 µM -2.38621151786955 0.0109837090350075 no 3310 0.00851147854122663 4676 693629 YIL048W NEO1 SGTC_3147 9097027 49.47 µM -2.38798380506884 0.0109335560091301 no 3311 0.00847054414662896 4747 25236841 SGTC_1341 1486-1360 280 µM -2.3885538009902 0.0109174683990139 no 3312 0.00845741576007968 4764 3976547 SGTC_1412 3909-8563 178 µM -2.41099998959531 0.0103001095856052 no 3313 0.00795442444753807 4788 23767530 SGTC_8 0354-0001 70 µM -2.4150842057179 0.010191112069842 no 3314 0.00786578616620873 4751 4993152 SGTC_1623 st003709 20.3 µM -2.43992057764158 0.00954970720596694 no 3315 0.00734524563775226 4741 16192618 SGTC_5 0352-0601 109.883 µM -2.44744885634045 0.00936238946620732 no 3316 0.00719357710847908 4682 762456 SGTC_438 sphingosine 6.67 µM -2.45190610542467 0.00925300625527207 no 3317 0.00710508682243231 4730 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1555 citronellol 128 µM -2.45358712054037 0.00921204463309567 no 3318 0.00707196367987161 4759 8842 A terpine precursor. SGTC_640 3381-0960 37.1 µM -2.47080652540537 0.00880151137361858 no 3319 0.00674043655606114 4783 1745025 SGTC_2047 4141938 200 µM -2.47265934320107 0.00875830810713066 no 3320 0.00670559561228514 4770 3807862 SGTC_1881 5652484 16 µM -2.47596552838012 0.00868167752106121 no 3321 0.00664382034524817 4743 2255129 SGTC_248 streptozotocin 5.23457 mM -2.49096002725423 0.00834146897188743 no 3322 0.00636992259484675 4774 5300 DNA alkylating agent. SGTC_2942 9052777 62.25 µM -2.50797886278402 0.00796956338681184 no 3323 0.00607119651856935 4750 6469503 SGTC_282 k297-0036 65.7 µM -2.52215127236578 0.0076710667097971 no 3324 0.00583197684764686 4764 5061378 SGTC_231 b-estradiol 524 µM -2.52302268395598 0.0076530386465091 no 3325 0.00581754476745892 4778 450 A steroid. SGTC_895 0964-0006 13.7 µM -2.52789614025144 0.00755290090748714 no 3326 0.00573741456489808 4756 6738897 SGTC_149 3970-0822 46.1 µM -2.53360066479785 0.00743715415590579 no 3327 0.00564486540371699 4746 3114250 YBL034C STU1 SGTC_1572 epiandrosterone 68.9 µM -2.53391549894784 0.00743081181879178 no 3328 0.00563979640922619 4755 441302 A steroid. SGTC_3156 9099931 49.47 µM -2.55237834081792 0.00706711368380825 no 3329 0.00534951337211294 4783 18111053 SGTC_1810 st050138 53 µM -2.65636447083933 0.00529754152505628 no 3330 0.0039494096850305 4788 3444541 SGTC_901 1112-0062 60.1 µM -2.65756549548524 0.00527964420376199 no 3331 0.00393536476575279 4782 1908457 SGTC_209 4077-0173 175.592 µM -2.65758928754709 0.00527929020525763 no 3332 0.00393508699116782 4750 15993494 SGTC_2990 9074105 71.4286 µM -2.69182829393777 0.00479120735477845 no 3333 0.00355307603628519 4743 6502001 SGTC_3028 9087778 49.47 µM -2.7720893614301 0.0038012749337942 no 3334 0.00278488719934759 4764 17217395 SGTC_2001 4023502 57.655 µM -2.78407585298958 0.00367033975995218 no 3335 0.00268402393442146 4771 108941 YCR052W RSC6 SGTC_1042 0350-0096 82 µM -2.78542255067114 0.00365588480036564 no 3336 0.00267290044950411 4774 3122515 SGTC_1696 st025591 34.7925 µM -2.80421618248536 0.00345942355151388 no 3337 0.0025219536564643 4782 2787147 SGTC_260 nsc-65238 3.989 µM -2.81215538949779 0.00337931897272396 no 3338 0.00246053617411057 4786 3246252 SGTC_1957 st077035 62.4 µM -2.82731452986916 0.00323098306286593 no 3339 0.00234700989407359 4781 705593 SGTC_386 1509-0011 3.07 µM -2.83177092339801 0.00318850441244243 no 3340 0.00231454996634842 4783 3107280 SGTC_419 nsc-638432 893 µM -2.86241544753124 0.00290975513332094 no 3341 0.00210212709862746 4787 368090 SGTC_1326 1431-2094 10.8 µM -2.86649043871074 0.00287439223554725 no 3342 0.00207525348278918 4790 616278 SGTC_555 4296-0685 37 µM -2.88106885951136 0.00275103142669683 no 3343 0.00198164521651156 4791 2908540 YHR072W ERG7 SGTC_1213 1315-0166 115 µM -2.89827215951697 0.00261161882322157 no 3344 0.00187612413261464 4773 768401 SGTC_2356 9061756 188.97 µM -2.92017976821409 0.00244333431261615 no 3345 0.00174914761826854 4781 20104043 SGTC_1036 k216-0215 33.5 µM -2.93722207264549 0.00231927512352069 no 3346 0.00165583431825718 4773 622330 SGTC_2037 5169046 200 µM -2.98344393877954 0.00201098970005744 no 3347 0.00142512122791649 4798 5718022 SGTC_907 3448-6986 75.5 µM -3.06273732405828 0.00156756305834572 no 3348 0.0010966124352379 4784 590582 SGTC_31 0508-1974 57.237 µM -3.17564765982615 0.00108885489211157 no 3349 0.000747512067250425 4793 6810525 SGTC_130 0136-0219 337.655 µM -3.30965306468919 0.000696169188036495 yes 3350 0.000467058379682115 4780 234244 SGTC_1367 1812-0510 76.9 µM -3.9082271228282 7.74585613330414e-05 yes 3351 4.64879407637225e-05 4807 1142582 YDR527W RBA50 SGTC_2304 7443016 91.4 µM -3.99768646415919 5.42495996870267e-05 yes 3352 3.19822996470776e-05 4799 939854 SGTC_666 0272-0154 136 µM -4.2998331583247 1.54340121327264e-05 yes 3353 8.54633705453944e-06 4809 6870312 SGTC_2357 9067248 200 µM -4.33818273202636 1.30793803727221e-05 yes 3354 7.1832843349528e-06 4784 9150235 SGTC_2810 7959871 45.46 µM -4.406000110505 9.72783111745072e-06 yes 3355 5.2648454498418e-06 4803 2974535 SGTC_1819 st053448 58.6 µM -4.44154898687936 8.31546400586265e-06 yes 3356 4.46568040869322e-06 4808 2857616