SGTCid condition conc unit FYV4|YHR059W.score FYV4|YHR059W.strain.pval FYV4|YHR059W.strain.significant FYV4|YHR059W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1761 st044296 37 µM 7.28906651242937 5.79467478403737e-14 yes 1 1.56054975403698e-13 1 1826700
SGTC_1876 myriocin 605 nM 6.27606734615341 8.02094831692521e-11 yes 2 1.73621911418284e-10 13 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_108 0509-0257 621.132 µM 5.57053979557899 6.72095842515585e-09 yes 3 1.26975650488376e-08 16 536624
SGTC_355 1311-2252 105 µM 4.84447575221158 3.81163702396178e-07 yes 4 6.34732097565916e-07 6 5338538
SGTC_174 3553-0389 74.3 µM 4.50401383256514 2.11397823945329e-06 yes 5 3.33409316267069e-06 13 738071
SGTC_1516 st013856 110 µM 4.31386531807355 5.23553726578042e-06 yes 6 8.02123499928591e-06 8 5281404 A mutagen and neurotoxin.
SGTC_180 1486-1293 102.781 µM 4.26809834348384 6.47811054911982e-06 yes 7 9.85732080535948e-06 35 4140536
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 4.21486624122244 8.2774128034228e-06 yes 8 1.2496313487725e-05 16 115019
SGTC_1454 4239-0054 42.6 µM 4.204675375028 8.67231056704128e-06 yes 9 1.30728571673071e-05 26 1340767
SGTC_2706 st078239 82.5 µM 4.2010152400243 8.81847392172087e-06 yes 10 1.32860350654933e-05 6 15434492
SGTC_800 3448-7362 155 µM 4.12806798086379 1.22706103263421e-05 yes 11 1.82911986557152e-05 146 15991913
SGTC_2299 7976368 114.88 µM 4.08070011982548 1.51639922610723e-05 yes 12 2.24501264131049e-05 29 2979718
SGTC_3052 9092717 49.47 µM 3.96426279583057 2.52796350735909e-05 yes 13 3.68115562111478e-05 27 25237534
SGTC_3140 9094243 49.47 µM 3.91018874053959 3.19070837721028e-05 yes 14 4.61120154523113e-05 25 19291112
SGTC_637 1181-0519 7.26 µM 3.85218386663546 4.08293691065379e-05 yes 15 5.85345320974089e-05 111 6252091 YGR060W ERG25
SGTC_664 1222-0054 14.9 µM 3.80943411482883 4.8863077298548e-05 yes 16 6.96426077890659e-05 40 6813991
SGTC_630 4356-0227 183 µM 3.79490996683415 5.1916751393539e-05 yes 17 7.38485214456309e-05 12 779312
SGTC_948 3448-0295 75.3 µM 3.79436822023989 5.20340652528204e-05 yes 18 7.40099354206578e-05 31 678569
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.68114777874304 8.28748904006486e-05 yes 19 0.000116093187683789 25 6312947
SGTC_104 0074-0074 590.992 µM 3.65812901431401 9.09610123854203e-05 yes 20 0.000127031578515401 9 3943124
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 3.56061239391191 0.000134171246177126 yes 21 0.000184995450085745 26 16486 A toxic proline analog.
SGTC_3221 9128209 49.47 µM 3.55988030972517 0.000134558622255045 yes 22 0.000185511929525158 25 16460723
SGTC_3251 9135047 49.47 µM 3.36696792012235 0.000282475952604398 yes 23 0.000379997643077136 16 17682963
SGTC_2858 9025781 8.96 µM 3.36549200894653 0.000284043735927044 yes 24 0.000382036401776211 138 4894980 YPL153C RAD53
SGTC_2802 7925815 54.55 µM 3.34587870217764 0.000305662040273433 yes 25 0.000410111341353053 66 1262923
SGTC_889 0919-1524 82.7 µM 3.19367154337303 0.00053330926196539 yes 26 0.000702379240880641 34 3905452
SGTC_541 4513-1321 94 µM 3.18546779832808 0.000549203298345494 yes 27 0.000722600932886766 47 747515
SGTC_1687 st020778 55.3625 µM 3.13914754435029 0.000647467463925928 yes 28 0.000847200551034755 224 4259299
SGTC_2370 9071495 200 µM 3.0208465062315 0.000976629307780239 yes 29 0.0012603455341449 63 21791103
SGTC_2752 diclazuril 33.15 µM 2.98310839609323 0.00111032565253613 no 30 0.00142668459571344 201 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1189 1431-2119 7.28 µM 2.97666762731139 0.00113475248060415 no 31 0.00145699866669576 86 3107275
SGTC_2441 5730946 39.09 µM 2.96677226229273 0.00117324149697391 no 32 0.0015047188981852 60 1774275
SGTC_612 0302-0167 22.4 µM 2.91907732817302 0.00137607036088592 no 33 0.00175534562434302 96 235821
SGTC_2328 6201408 200 µM 2.89363255714398 0.00149692835444436 no 34 0.00190406755975644 62 2890418
SGTC_600 1495-0418 41.6 µM 2.87189566520145 0.00160776099014021 no 35 0.00204008826301945 54 5377768
SGTC_1318 1280-3875 124 µM 2.83620664166792 0.00180604761408408 no 36 0.00228264486678081 90 373245
SGTC_2109 5483026 200 µM 2.80824448541985 0.00197666986271727 no 37 0.00249061970472567 91 759335
SGTC_629 3448-6466 76.7 µM 2.80710489113929 0.00198392426817412 no 38 0.00249944807866158 78 573744
SGTC_2154 5570129 200 µM 2.79067294267444 0.0020912484335944 no 39 0.00262992959224469 87 673366
SGTC_2324 6149169 200 µM 2.77387939508625 0.00220635120681407 no 40 0.00276961046744956 65 2888231
SGTC_2332 7982454 138.89 µM 2.75659789361881 0.00233076476991934 no 41 0.00292030634065275 126 2981748
SGTC_2703 st077852 53.4 µM 2.75131305424137 0.00237006043570425 no 42 0.00296784442942367 87 6281836
SGTC_2831 7999036 19.48 µM 2.74680104446856 0.00240408316058541 no 43 0.00300898141700375 134 2988270
SGTC_2450 5739737 12.93 µM 2.7357335920767 0.00248941635045952 no 44 0.00311206965720272 83 2262825
SGTC_1764 st044502 93.5 µM 2.73106779321878 0.00252620462410564 no 45 0.00315647421011282 110 8407
SGTC_3255 9139072 49.47 µM 2.7231521714059 0.00258974230945239 no 46 0.00323311330892705 80 17646060
SGTC_1082 camptothecin 424.86 nM 2.72264034678667 0.00259389994243469 no 47 0.00323812594301855 118 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1038 k292-0204 154 µM 2.71077394919495 0.00269199908573954 no 48 0.00335631860132786 68 4454212
SGTC_1294 1000-1494 117 µM 2.68188246476195 0.00294499742971095 no 49 0.00366045880715835 99 712797 YDL207W GLE1
SGTC_849 0386-0493 241 µM 2.66713538681381 0.0030822272929107 no 50 0.00382504237639138 82 726119
SGTC_641 4092-0595 30 µM 2.66208692603659 0.00313051277253652 no 51 0.00388289103793032 77 786260
SGTC_3055 9094636 49.47 µM 2.6525712061674 0.00322337999240742 no 52 0.00399406385329629 71 25236176
SGTC_791 1348-1292 225 µM 2.64702407548758 0.00327865290998402 no 53 0.00406017857869849 138 5437054
SGTC_2531 methyl deoxycholate 70.07 µM 2.64463714811989 0.00330269801162483 no 54 0.0040889279320729 109 16667744 Haematoxylin.
SGTC_585 0kpi-0023 191 µM 2.63798019774758 0.00337059790169956 no 55 0.00417007259354518 90 64601
SGTC_3148 9097893 49.47 µM 2.63424813309765 0.00340921087787166 no 56 0.00421619195535509 113 17174100
SGTC_1007 4101-0031 70 µM 2.62236145390584 0.00353485692577807 no 57 0.00436613819995861 91 1146276
SGTC_1743 st037606 46.3785 µM 2.61120393392457 0.00365656232430906 no 58 0.00451120364010405 112 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1181 1222-0449 220 µM 2.61001817672824 0.00366971499639798 no 59 0.00452687059327115 103 658318
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.60092253027399 0.0037720255953141 no 60 0.00464867234109177 139 91467 include heat shock
SGTC_991 3996-0057 64.7 µM 2.57767512134226 0.00404523663956774 no 61 0.00497337331277617 90 715343
SGTC_1373 2887-0003 58.5 µM 2.57408893666084 0.00408892436518393 no 62 0.00502522173612678 115 776948
SGTC_432 NS 1619 61.3 µM 2.56774571205377 0.00416723402108517 no 63 0.00511811075715395 123 4552 A K+/calcium channel activator.
SGTC_2741 miltefosine 3.04 µM 2.51681277196957 0.00484625014494114 no 64 0.00592108698072235 94 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2197 6588183 93.1375 µM 2.50968366873089 0.00494877332711375 no 65 0.00604196780647729 80 884136
SGTC_1891 st059073 26.2 µM 2.50524295577263 0.00501360743917322 no 66 0.0061183653007996 114 688754
SGTC_2152 5568786 200 µM 2.50428386168272 0.00502770908855731 no 67 0.00613497739480552 96 5399883
SGTC_1423 4048-0112 5.59 µM 2.46556538592866 0.00562731278057815 no 68 0.00683986025946099 118 X1423
SGTC_3079 9117512 49.47 µM 2.46028005560559 0.00571390647508438 no 69 0.00694143182177026 39 7185044
SGTC_1766 st045414 44.774 µM 2.43643981742099 0.00611937264709444 no 70 0.0074163187166734 158 253960
SGTC_2366 9070441 60.58 µM 2.43514098110918 0.0061421775674636 no 71 0.00744299429231524 143 6837235
SGTC_2502 avocadyne acetate 18.59 µM 2.4212102595125 0.00639154783146154 no 72 0.00773446353933225 162 3952079
SGTC_422 cantharidin 155 µM 2.40461873337452 0.0067002063296451 no 73 0.00809467309531336 198 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_453 enantio-paf c16 10 µM 2.39817333119011 0.00682362057439787 no 74 0.00823853309205801 366 13871343 A lipid and platelet activating factor
SGTC_1633 st005664 67.9 µM 2.39261400278841 0.0069316770629176 no 75 0.00836441506521906 172 2063822
SGTC_1220 1838-0075 193 µM 2.38981011730231 0.00698674709950693 no 76 0.00842854279434402 119 5529645
SGTC_3302 9125395 16.351 µM 2.38207487991249 0.00714067930744626 no 77 0.00860769823554452 117 17599668
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.36878490253618 0.00741214628629023 no 78 0.00892331461858589 140 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1613 st002381 52.1 µM 2.35972034293811 0.00760248140819192 no 79 0.00914435811249744 130 551167
SGTC_3099 9120367 49.47 µM 2.35286079331215 0.00774936401959748 no 80 0.00931480348288242 117 24824940
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.34843883952602 0.00784536935045006 no 81 0.00942614751367684 151 3256 An antibiotic and ribosome inhibitor.
SGTC_2507 purpurin 79.67 µM 2.34610494030533 0.00789646142723935 no 82 0.00948538268412214 176 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1178 0988-0033 191 µM 2.34108395830998 0.00800737026185481 no 83 0.00961392131962139 182 5392207
SGTC_2330 7979373 200 µM 2.34063916521203 0.0080172610482245 no 84 0.00962538122327041 165 1863007
SGTC_1287 0971-0001 34.6 µM 2.33112931664236 0.00823131489297782 no 85 0.00987327092541164 197 4665869
SGTC_1578 josamycin 24.2 µM 2.32108177509276 0.00846290978214631 no 86 0.01014121540045 122 5282165 A P450 substrate.
SGTC_1625 st003711 30.1 µM 2.32101211396152 0.00846453522661208 no 87 0.0101430950296299 154 24207034 YER133W GLC7
SGTC_15 0266-0086 27.098 µM 2.31465565805366 0.00861401215823011 no 88 0.0103158921376062 224 1712902 YIL048W NEO1
SGTC_747 3448-8087 38.7 µM 2.30592792598911 0.00882302136213533 no 89 0.0105573299609801 174 5168703
SGTC_859 0439-0102 54.6 µM 2.29973367181189 0.00897404385216072 no 90 0.0107316566213398 145 610143
SGTC_2088 5278280 127.392 µM 2.29357772268575 0.00912637116009353 no 91 0.0109073831111881 184 791502
SGTC_14 0354-0009 295 µM 2.28649483211538 0.00930443194869302 no 92 0.0111126630573664 149 1713507
SGTC_1493 4348-0038 111 µM 2.27145182370581 0.00969271815537326 no 93 0.0115598201175443 188 800424
SGTC_90 0870-0863 4.608 µM 2.26957440901454 0.00974215767943585 no 94 0.011616708896567 194 1738164
SGTC_1635 st007035 42.4 µM 2.26667958582179 0.00981882121551349 no 95 0.0117049031838161 407 3716403
SGTC_841 0251-0215 91.2 µM 2.26449919395935 0.00987691187363606 no 96 0.0117717146380709 208 3888614
SGTC_2292 7671323 168.05 µM 2.26240338093276 0.00993303180217315 no 97 0.0118362461197443 201 937504
SGTC_2414 st077232 92.9 µM 2.26120542858884 0.00996523444706809 no 98 0.0118732695561461 164 729801
SGTC_1129 3453-1384 223 µM 2.26091916844174 0.00997294300021856 no 99 0.0118821314555789 193 1084452
SGTC_47 0149-0135 24.25 µM 2.2507430571035 0.0102503729027046 no 100 0.012200907987574 158 5239155
SGTC_2365 9042475 200 µM 2.24694159660367 0.010355725304408 no 101 0.0123218799276154 181 6464479
SGTC_2497 7-hydroxyflavone 100 µM 2.24517782934971 0.010404925521692 no 102 0.0123783593948095 154 5281894
SGTC_1242 0402-0103 60.1 µM 2.23795881731386 0.0106084292681046 no 103 0.012611870425637 149 432868
SGTC_3318 9139014 38.6185 µM 2.23388479331881 0.0107247994243544 no 104 0.012745327189534 133 16643984
SGTC_1072 oxiconazole 14.9 nM 2.23010010594002 0.0108338993154484 no 105 0.0128703989008487 194 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1683 st010134 710 nM 2.22050989798361 0.011114688410029 no 106 0.0131920872727536 190 3818134
SGTC_1219 1469-0211 33.1 µM 2.20251568412101 0.011658645889328 no 107 0.0138144512399089 126 6822282
SGTC_1361 1608-0041 5.61 µM 2.18651496804736 0.0121616049341249 no 108 0.0143889754106383 162 X1361
SGTC_157 1348-1695 65.819 µM 2.18348317574639 0.0122589954451345 no 109 0.0145001233034626 263 5380510
SGTC_1704 st028805 70.8 µM 2.16924666313611 0.0127254054794035 no 110 0.0150319810947376 136 2876101
SGTC_2293 7624732 200 µM 2.16395611826456 0.0129026040682636 no 111 0.0152338586803395 174 894453
SGTC_2319 6033012 152.6 µM 2.15928507964253 0.0130608229367867 no 112 0.0154140284781861 144 847246
SGTC_1252 0493-0875 34.8 µM 2.1586353148037 0.0130829643012999 no 113 0.0154392353708523 194 3960963
SGTC_2749 bexarotene 57.39 µM 2.1581966524843 0.0130979304814023 no 114 0.0154562727828175 211 82146 An retinoic acid receptor inhibitor.
SGTC_143 4032-1194 15.74 µM 2.15618652565761 0.0131667009346256 no 115 0.0155345516290023 254 1806963
SGTC_2796 7949634 45.45 µM 2.14033344440221 0.0137200832507855 no 116 0.0161639145058209 199 2971588
SGTC_1335 1486-0900 202 µM 2.13663499433466 0.0138520341495428 no 117 0.0163138455128599 216 X1335
SGTC_1807 st050092 58.9 µM 2.13426551808798 0.0139371447269176 no 118 0.0164105260989523 181 5008496
SGTC_1762 st045503 25.4615 µM 2.13252627669286 0.0139999041139809 no 119 0.0164818033490995 195 4645554
SGTC_3134 9127454 49.47 µM 2.12037244908645 0.0144453036731158 no 120 0.0169873241185112 146 24262820
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.11509417423945 0.0146425033240867 no 121 0.0172109608301428 211 688667
SGTC_2058 5236698 133 µM 2.1090088276233 0.0148727261880141 no 122 0.0174719098342188 198 766665
SGTC_1539 benzyladenosine 56 µM 2.10838930127162 0.0148963379457986 no 123 0.0174986645536977 163 92208 A nucleotide analog.
SGTC_1253 0550-0034 176 µM 2.10769125445566 0.0149229809318433 no 124 0.0175288521403615 186 5969915
SGTC_2296 7971656 126.45 µM 2.10531735222791 0.0150138945997828 no 125 0.0176318463195226 218 666570
SGTC_377 3970-0964 33.1 µM 2.09406464272568 0.0154513454696291 no 126 0.0181271111010216 295 16481235
SGTC_3007 9078383 71.4286 µM 2.09242820989903 0.0155158646354486 no 127 0.0182001137399081 197 6496995
SGTC_1910 st062352 60.4 µM 2.08802254490683 0.0156907159510978 no 128 0.0183979005269429 237 2245730
SGTC_1016 4226-1401 38 µM 2.08257178344012 0.0159093820352824 no 129 0.0186451367076904 206 2901613
SGTC_922 1866-0035 480 µM 2.07852650283723 0.0160733493489727 no 130 0.018830446238292 293 3156169
SGTC_1074 carmofur 3.8 µM 2.0693811151605 0.0164493848953706 no 131 0.0192551686143339 254 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2825 7998094 58.44 µM 2.06679106740725 0.0165572401559418 no 132 0.0193769227748931 208 2987815
SGTC_1013 4112-3890 241 µM 2.06013794106972 0.0168370688896343 no 133 0.0196926778216209 211 705171
SGTC_1053 3366-3204 134 µM 2.05380547401454 0.017107157940481 no 134 0.0199972614655181 226 3632071 YPR165W RHO1
SGTC_2186 6124449 200 µM 2.05311803435178 0.0171366998407504 no 135 0.0200305656485149 199 3834182 YLR033W RSC58
SGTC_1644 st010134 20.9 µM 2.04823120360931 0.0173479646782418 no 136 0.0202686751652404 163 3818134
SGTC_2207 7258803 200 µM 2.0466468561238 0.0174169341154812 no 137 0.02034638535807 144 3666799
SGTC_77 0828-0286 12.516 µM 2.03974306438705 0.0177202079083341 no 138 0.0206879616359326 244 745345
SGTC_978 1416-0512 87.4 µM 2.03893873731708 0.0177558321896422 no 139 0.020728071082704 236 6814003
SGTC_2614 arthonioic acid 13.39 µM 2.02928559071455 0.0181881666936267 no 140 0.0212146050480905 199 6710684
SGTC_506 n9-isopropylolomoucine 153 µM 2.02464281219057 0.0183992772439264 no 141 0.0214520273945117 197 6610355
SGTC_1883 5-benzylidenerhodanine 20 µM 2.01618449685137 0.0187892497948909 no 142 0.0218903434714118 304 1273210
SGTC_2713 st079149 53.4 µM 2.01076469807445 0.0190428103489555 no 143 0.022175158285845 233 3103253
SGTC_2988 9073640 71.4286 µM 2.01063391765767 0.019048964576149 no 144 0.0221820693617249 208 9102229
SGTC_1313 1220-0047 237 µM 2.00864366797522 0.0191428300873883 no 145 0.0222874683785395 259 3528706
SGTC_2093 5331342 194.4 µM 2.0056938919622 0.0192826725616858 no 146 0.022444458648378 202 33839
SGTC_3096 9117468 49.47 µM 2.00552285304038 0.019290807706853 no 147 0.022453590058593 126 41316311
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 2.00367046527448 0.0193791000620428 no 148 0.0225526860296835 194 279621
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.00058321837687 0.0195270137908308 no 149 0.0227186617836548 169 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_13 0199-0087 65 µM 1.98785962649478 0.020146776315572 no 150 0.0234136085058447 201 4589825
SGTC_1466 k213-0079 57.5 µM 1.98684276001892 0.0201970195686023 no 151 0.0234699122088918 225 3657981
SGTC_1972 st070201 17.4 µM 1.98517156046271 0.02027982412513 no 152 0.0235626936409178 214 2829099
SGTC_2782 7736369 71.43 µM 1.98488416047254 0.020294093176482 no 153 0.0235786805245478 270 2950836 YOL077C BRX1
SGTC_972 1319-0219 195 µM 1.97370359250603 0.0208558375327233 no 154 0.0242077282228546 222 23903702
SGTC_2688 kanamycin b 96.69 µM 1.96002788033783 0.0215607905486708 no 155 0.0249962658394672 809 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2508 celastrol 40.54 µM 1.95663401423889 0.0217388231323118 no 156 0.0251952564759169 184 122724 Celastrol is a natural product and antioxidant.
SGTC_1526 st051518 75 µM 1.94969235434026 0.0221068326469828 no 157 0.0256063990744969 225 673993
SGTC_1027 k015-0025 8.67 µM 1.92082679762627 0.0236940085783838 no 158 0.0273767734393058 249 3598955
SGTC_2834 9001755 58.44 µM 1.91474736388386 0.0240402280834682 no 159 0.0277623650412472 238 2989575
SGTC_2205 7238770 200 µM 1.91141625033887 0.0242317286422834 no 160 0.0279755550059272 176 279867
SGTC_115 0527-0192 112.043 µM 1.89941071672786 0.0249325696378881 no 161 0.0287552477700123 377 4233931
SGTC_645 0845-0943 5.41 µM 1.89698440342389 0.025076254691104 no 162 0.0289149982890337 231 1885106
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.8963124026622 0.0251161727605675 no 163 0.0289593736067364 194 688803
SGTC_2266 7929956 200 µM 1.89515403265247 0.0251851070783823 no 164 0.0290359990000683 268 2967153
SGTC_1888 azatryptophan 97.5 µM 1.8922466810804 0.0253588215215374 no 165 0.0292290606736087 206 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_163 TUB2.036 7.546 µM 1.88630387967196 0.0257170281333308 no 166 0.0296270083872669 443 15992207 YJR013W GPI14
SGTC_1167 k781-0610 148 µM 1.88192844109003 0.0259834595874253 no 167 0.0299228661149242 288 4525169
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.88082723424597 0.0260508773498268 no 168 0.0299977120872462 295 5379071
SGTC_1150 3909-7983 10.9 µM 1.87095131412947 0.026662062749735 no 169 0.0306759147669039 298 23965914
SGTC_491 tetrandrine 80.3 µM 1.8700930513203 0.0267157386229723 no 170 0.0307354486302447 187 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1123 mangostin 811.285 nM 1.86293528458199 0.0271669105706573 no 171 0.0312356858887324 301 5281650 An antioxidant.
SGTC_1487 3970-0795 2.82 µM 1.85003318401474 0.0279962181300543 no 172 0.0321543834671648 263 3765103
SGTC_1564 D-Arginine 115 µM 1.84215935521084 0.0285126065552029 no 173 0.032725921881873 288 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2007 4011539 71.82 µM 1.83683377238781 0.0288663465016085 no 174 0.0331172192935718 294 45595301
SGTC_61 0978-8327 98.565 µM 1.83501088664936 0.0289882625745487 no 175 0.0332520382061905 292 6150059 YHR072W ERG7
SGTC_99 0109-0120 622.8 µM 1.83206036762903 0.0291865023415286 no 176 0.0334712135899657 227 759414
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.83155977085431 0.0292202479752116 no 177 0.0335085175080145 261 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2357 9067248 200 µM 1.83082018411293 0.0292701634211068 no 178 0.0335636933231799 231 9150235
SGTC_1091 telmisartan 47.6 µM 1.82592507768431 0.0296023274769233 no 179 0.0339307740780494 265 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1264 0783-0040 158 µM 1.82159407720541 0.0298988161386791 no 180 0.0342583001426321 266 2855798
SGTC_2841 9004761 38.96 µM 1.8195311320757 0.0300409034549032 no 181 0.0344152188202004 265 2991039
SGTC_3032 9089427 49.47 µM 1.81818137705376 0.0301341717840039 no 182 0.0345182076974329 256 17173707
SGTC_3352 9151559 45.5865 µM 1.81730744913569 0.0301946883082053 no 183 0.0345850249997087 264 17159339
SGTC_975 1335-0046 28.5 µM 1.81063016788556 0.0306604001570593 no 184 0.0350990595532622 311 16486740
SGTC_2773 thioridazine 9.09 µM 1.81015849087522 0.0306935213184648 no 185 0.0351356062982281 261 5452 An antipsychotic.
SGTC_2275 7947463 200 µM 1.79782392147351 0.0315702266285985 no 186 0.0361024576294969 256 1225414
SGTC_712 r015-0009 80.6 µM 1.79743249422617 0.0315983835027926 no 187 0.036133493000738 248 6813872 YLR060W FRS1
SGTC_957 1187-1561 14.1 µM 1.79681205132655 0.0316430568771381 no 188 0.036182731255055 317 1538454
SGTC_1626 st003712 1.76 µM 1.79517425335498 0.0317612330392229 no 189 0.036312970607762 275 24207035
SGTC_45 0kpi-0036 14.9 µM 1.78415031801915 0.0325661914630772 no 190 0.037199621391955 265 2795021
SGTC_3217 9129673 49.47 µM 1.780389354481 0.0328446342209643 no 191 0.0375061313758242 315 17248312
SGTC_1191 1487-1166 10.6 µM 1.76934587847661 0.0336735982882084 no 192 0.038418085777486 363 3955771
SGTC_1154 4088-0362 150 µM 1.7672257780546 0.0338346944961935 no 193 0.0385952121089927 357 6618304
SGTC_2845 9003024 42.97 µM 1.76722161377467 0.0338350115425368 no 194 0.0385955606724588 330 2990173
SGTC_2843 9000894 45.46 µM 1.76602215289837 0.0339264339645025 no 195 0.0386960661892729 174 2242070
SGTC_1151 3909-8316 15.3 µM 1.76249051461989 0.0341967944434916 no 196 0.0389932288009091 299 800431
SGTC_358 0075-0058 9.45 µM 1.76245775950154 0.0341993102390182 no 197 0.0389959935867001 408 1069125
SGTC_493 zm226600 134 µM 1.75866671335207 0.0344915155118454 no 198 0.0393170671669419 304 5240098 A potassium channel opener. YCR052W RSC6
SGTC_635 k038-0028 24.7 µM 1.7562971072819 0.0346751989040124 no 199 0.0395188454786854 324 4035102
SGTC_1730 st033808 45.1 µM 1.74056184128898 0.0359154170151616 no 200 0.0408802056274222 374 1045166
SGTC_1604 st002052 72.4 µM 1.74052507865688 0.0359183565600955 no 201 0.0408834301909342 315 6254834 YHR062C RPP1
SGTC_1159 4092-0538 61.2 µM 1.73583944251365 0.0362946372368912 no 202 0.0412961139152003 332 717301
SGTC_2904 7225135 42.03 µM 1.72872897970267 0.0368718022098493 no 203 0.041928806085693 292 4446116
SGTC_43 0570-0105 72.5 µM 1.7268654610182 0.0370243011479721 no 204 0.0420959143484129 468 1114046 YDL195W SEC31
SGTC_1583 clindamycin 39.6 µM 1.72380009259014 0.0372762733256595 no 205 0.0423719689537145 296 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.71958834596003 0.0376247604779433 no 206 0.0427536480308851 371 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3306 9127676 59.7925 µM 1.71793506992783 0.0377622803411767 no 207 0.0429042295898612 322 41905287
SGTC_3213 9129884 49.47 µM 1.71407125828205 0.0380852731962183 no 208 0.0432578198180187 271 17190742
SGTC_249 wiskostatin 11.211 µM 1.71072945592309 0.0383664431233757 no 209 0.0435655337143598 291 2775510 A n-wasp and actin depolymerizer.
SGTC_1353 1498-1206 8.11 µM 1.70614572388562 0.0387548556275775 no 210 0.0439904756118933 384 6756808
SGTC_832 4083-0019 164 µM 1.70550441369574 0.0388094529873413 no 211 0.0440501949071795 526 1990758
SGTC_149 3970-0822 46.1 µM 1.6997612885481 0.0393011864572075 no 212 0.0445879179060878 498 3114250 YBL034C STU1
SGTC_2124 5246320 200 µM 1.69633522657197 0.0395969365775999 no 213 0.0449112064386263 321 579342
SGTC_1162 k048-0130 20.1 µM 1.68470925241799 0.0406140504297273 no 214 0.0460223402601902 324 6797406
SGTC_1453 4237-0541 195 µM 1.68426735545859 0.0406531248529355 no 215 0.0460650056389754 312 739892
SGTC_2390 9097792 176.6 µM 1.68222340947961 0.0408342564344289 no 216 0.046262763191662 300 4497149
SGTC_2995 9067767 71.4286 µM 1.68081888573299 0.0409591024666149 no 217 0.0463990495824198 281 11673567
SGTC_2720 fluspirilene 36.88 µM 1.68078464547584 0.0409621498938497 no 218 0.0464023760675848 253 3396 An atypical antipsychotic.
SGTC_2092 5303694 80.6725 µM 1.6798756471642 0.0410431191912619 no 219 0.0464907564534843 363 1963699
SGTC_2045 5106652 78.05 µM 1.67695214026368 0.0413044118570313 no 220 0.0467759205188433 308 673349
SGTC_2200 6600604 21.907 µM 1.67429402475691 0.0415431535774765 no 221 0.0470364141301778 374 2904777
SGTC_974 1326-0144 138 µM 1.66422102066444 0.0424580365564956 no 222 0.0480341343966352 383 5411856
SGTC_476 mead acid 10 µM 1.66215197691629 0.0426479606404905 no 223 0.0482411530576568 231 5312531 An omega 9 fatty acid.
SGTC_2754 granisetron 64.02 µM 1.65809094371018 0.043022732716815 no 224 0.0486495557776747 365 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2681 menadione 3.18 µM 1.65018872894051 0.0437596122335896 no 225 0.0494521706876773 346 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_59 0330-0160 1.33 µM 1.64920724882278 0.0438518416875163 no 226 0.049552591709407 524 4293482
SGTC_3239 9133757 49.47 µM 1.64862612118592 0.0439065239775446 no 227 0.0496121269723466 277 17036923
SGTC_522 1273-0010 11.6 µM 1.64796241127455 0.0439690442625084 no 228 0.0496801924179596 337 5705015
SGTC_2106 5357045 167.29 µM 1.64622202913733 0.0441333261493536 no 229 0.0498590277195129 362 668842
SGTC_126 0417-1624 672.48 µM 1.64221503980533 0.0445134439958567 no 230 0.0502727234529132 439 41912 YDL195W SEC31
SGTC_3179 9107801 49.47 µM 1.6376228530678 0.0449523146420038 no 231 0.0507501963884146 333 4818259
SGTC_1012 4112-3522 18 µM 1.63654963505808 0.045055381500606 no 232 0.0508623032751349 347 3112398
SGTC_2194 5927483 104.545 µM 1.63536105174449 0.0451697493658865 no 233 0.0509866910629502 377 760979
SGTC_654 1124-0271 80.9 µM 1.6332715209999 0.0453713743997629 no 234 0.0512059518225152 385 5403748
SGTC_1319 1306-0155 43.7 µM 1.63129058224283 0.0455631888984686 no 235 0.0514145098171418 399 3122360
SGTC_762 1165-0429 115 µM 1.62312961761324 0.046360302115079 no 236 0.0522808497296937 368 5967793
SGTC_593 1203-0218 61.7 µM 1.62073263354352 0.0465965401841352 no 237 0.0525374958462475 349 3666956
SGTC_184 1494-0393 24.714 µM 1.61763162826525 0.046903596248307 no 238 0.0528710043459149 397 3090647
SGTC_3026 9090633 49.47 µM 1.61589250771208 0.0470765098755507 no 239 0.0530587778954696 355 25236842
SGTC_1155 4088-0394 48.2 µM 1.60870506486061 0.0477965554449575 no 240 0.0538404238977289 377 2326248
SGTC_1194 1488-0194 225 µM 1.60637653690555 0.0480317119577906 no 241 0.0540956014737614 413 1391452
SGTC_1474 0330-0125 5.35 µM 1.60570495876654 0.0480997059626917 no 242 0.0541693756259339 357 X1474
SGTC_264 promethazine 12.5 mM 1.60521702198673 0.0481491554714761 no 243 0.0542230263429943 491 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2576 guaiol 23.12 µM 1.60279500503539 0.0483952149614744 no 244 0.0544899599937656 392 227829
SGTC_3271 9137798 49.47 µM 1.60252598760151 0.0484226071415104 no 245 0.0545196727758298 280 6498326
SGTC_801 0866-0028 10.1 µM 1.5970496595084 0.0489829237539132 no 246 0.0551273190789846 404 6849771
SGTC_2737 bleomycin 30.5 nM 1.59297839429468 0.0494028272329063 no 247 0.0555825190201778 434 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_408 cantharidin 100 µM 1.59219336400759 0.0494841234541186 no 248 0.0556706319173219 411 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1742 st038235 28.8875 µM 1.59003487694913 0.0497082027235196 no 249 0.0559134718495783 427 564103 YBR002C RER2
SGTC_3010 9080089 71.4286 µM 1.58867469795322 0.0498498224675546 no 250 0.056066927077384 356 17027233
SGTC_2185 6113692 200 µM 1.58602036513796 0.0501271142200791 no 251 0.056367344954263 345 874150
SGTC_1778 st046819 58.9 µM 1.57941386252834 0.0508226202029304 no 252 0.0571205798753844 433 671715
SGTC_2375 9072683 200 µM 1.57911710725047 0.0508540408205462 no 253 0.0571545992279336 412 16798029
SGTC_1197 1601-0112 267 µM 1.57749832229111 0.0510257110733184 no 254 0.0573404539176081 403 7350313
SGTC_2927 9011802 47.9 µM 1.57023320303053 0.0518018559496985 no 255 0.0581804338381142 387 43912568
SGTC_2875 9039966 71.43 µM 1.56986905101622 0.0518410045154167 no 256 0.0582227895212404 313 6463691
SGTC_235 0330-0087 5 mM 1.56753482414047 0.0520925068662747 no 257 0.058494866470172 419 46494818 YHR062C RPP1
SGTC_560 2332-1943 155 µM 1.56636015036684 0.0522194387328182 no 258 0.0586321632810536 366 21177716
SGTC_1909 st060837 51.5 µM 1.56066485786086 0.0528383417598988 no 259 0.0593014235192817 418 678937
SGTC_1339 1486-1321 22.7 µM 1.55838244610736 0.0530879970613777 no 260 0.0595713076487059 398 3469382
SGTC_350 k064-0020 19.8 µM 1.55829352362459 0.0530977424989212 no 261 0.0595818417510843 428 2790705
SGTC_932 2857-0803 154 µM 1.55732631297369 0.0532038353605726 no 262 0.0596965155954511 413 674898
SGTC_2652 actinonin 100 µM 1.5534506834533 0.0536306380111813 no 263 0.0601577512300219 322 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_599 1935-0052 86.5 µM 1.55250926923167 0.0537347193276201 no 264 0.0602702082778005 414 9557311
SGTC_7 0192-1582 4.227 µM 1.55019406486015 0.0539913653030069 no 265 0.0605474719746681 483 252616
SGTC_2069 5228469 200 µM 1.541185230569 0.054999261679747 no 266 0.0616358555146185 362 2835210
SGTC_1237 0330-0133 46.1 µM 1.53642515316266 0.0555377842184438 no 267 0.0622170708156191 377 X1237 YHR072W ERG7
SGTC_1669 st015249 58.4 µM 1.53144133881409 0.0561060705308351 no 268 0.0628301769594962 365 722793
SGTC_2053 5265679 138 µM 1.52640437739623 0.0566850663183735 no 269 0.0634545940839753 423 764595
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.52587179443988 0.0567465605805572 no 270 0.0635208981634527 494 368090
SGTC_1872 amphotericin b 148 nM 1.5225714853887 0.0571288006208786 no 271 0.0639329741058149 415 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1278 0874-0585 172 µM 1.52042243328265 0.0573787902728591 no 272 0.0642024199347129 391 766306
SGTC_2478 5763493 32.33 µM 1.51872578311416 0.0575767613569574 no 273 0.0644157669427081 414 1365576 YLR208W SEC13
SGTC_195 4234-0266 16.654 µM 1.51840537120321 0.0576142083778531 no 274 0.0644561192330942 464 2303354
SGTC_556 4058-0063 51.5 µM 1.51350321527847 0.0581895221370206 no 275 0.065075942527858 434 6615692
SGTC_687 k029-0044 34.9 µM 1.51045356177386 0.0585496985646193 no 276 0.0654638651528411 427 5829338
SGTC_2606 farnesol 9.78 µM 1.50818987838313 0.0588181788027288 no 277 0.0657529685202279 428 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1279 0874-0590 65.2 µM 1.50437800310769 0.0592724618055633 no 278 0.0662420324052984 422 3523074
SGTC_2419 paclitaxel 166.5 µM 1.5033836060946 0.059391421113029 no 279 0.0663700758115804 499 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_952 1185-0122 232 µM 1.50322396883146 0.059410535877189 no 280 0.0663906493244524 431 678600
SGTC_2534 helenine 20.12 µM 1.50261837536232 0.059483092726897 no 281 0.0664687410714656 368 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1055 3448-0672 86 µM 1.50137128238651 0.0596327271447064 no 282 0.0666297786617392 414 748378
SGTC_2445 5742597 35.57 µM 1.49953105798246 0.0598540679459212 no 283 0.0668679588755909 402 1774255
SGTC_926 2268-1401 59.4 µM 1.49734569995013 0.0601177564760995 no 284 0.0671516647023678 436 2931578
SGTC_2990 9074105 71.4286 µM 1.49712770919173 0.0601441093738924 no 285 0.0671800155028008 381 6502001
SGTC_330 1488-0319 80.1 µM 1.49470090561703 0.0604380967398259 no 286 0.067496258922344 409 6846614
SGTC_3143 9086658 49.47 µM 1.49461358327035 0.0604486960478354 no 287 0.0675076595422743 486 25236626
SGTC_2662 daunorubicin 22.37 µM 1.46434011651937 0.0642117963965271 no 288 0.0715505206296028 392 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_828 2074-0507 139 µM 1.46146504649554 0.0645784422549064 no 289 0.0719439305752995 468 X828
SGTC_2172 5754775 163.918 µM 1.46050057499507 0.0647018009364019 no 290 0.0720762748154006 426 2263357
SGTC_2477 5967686 25.23 µM 1.45992408308681 0.0647756232470038 no 291 0.0721554697835366 453 776118
SGTC_3292 9120825 59.784 µM 1.45766679222796 0.0650653087771866 no 292 0.0724662047279476 428 24824900
SGTC_50 0929-0078 56.389 µM 1.45409738800728 0.0655254328213723 no 293 0.0729596538250553 437 1377751
SGTC_2903 5923464 63.88 µM 1.44949638566526 0.0661222556688679 no 294 0.0735995044833573 416 2876576
SGTC_2340 7987427 183.45 µM 1.44867726881487 0.0662289482969164 no 295 0.0737138656912105 443 2239331
SGTC_583 1488-1091 88.9 µM 1.44415909547598 0.0668198528105319 no 296 0.0743471140388157 544 4303273
SGTC_2769 toremifene 3.73 µM 1.44404701446826 0.0668345628872823 no 297 0.07436287548028 416 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_535 2293-4129 48.2 µM 1.43848040643888 0.0675683096207707 no 298 0.0751488964665429 546 396118 YIL048W NEO1
SGTC_46 0329-0187a 2.197 µM 1.43604263628506 0.0678915906079046 no 299 0.0754951046981041 575 46494817
SGTC_289 k017-0060 526 µM 1.43579291142671 0.0679247748039634 no 300 0.0755306387444223 405 5512909
SGTC_1048 3161-0300 24.5 µM 1.43438011209466 0.0681127477814837 no 301 0.0757319099467349 499 2165101
SGTC_2653 dihydrofissinolide 100 µM 1.43069892384963 0.0686044162188258 no 302 0.0762582608976527 405 6857746
SGTC_578 3460-0051 92 µM 1.42886707809581 0.0688500997947765 no 303 0.0765212207174439 510 2876744
SGTC_3112 9123419 49.47 µM 1.42443442761381 0.0694474044400562 no 304 0.0771603770754467 502 17015854
SGTC_1446 4239-0190 62 µM 1.42356814873118 0.0695646012911163 no 305 0.0772857607655358 508 1340085
SGTC_2867 9039098 71.43 µM 1.42229936788681 0.0697365264763387 no 306 0.0774696811643004 480 6463460
SGTC_2816 7982706 58.44 µM 1.42225959880027 0.069741920638038 no 307 0.0774754513940226 476 2981853
SGTC_168 3970-0862 530.542 µM 1.42067898573511 0.0699565704896345 no 308 0.0777050521978177 667 3135186
SGTC_237 nikkomycin 200 µM 1.41632320528995 0.0705507233548646 no 309 0.0783404483511397 491 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1483 3453-0561 55.9 µM 1.41518633478614 0.0707064353726764 no 310 0.0785069350352391 524 4546991
SGTC_475 α-linolenic acid 10 µM 1.41315065291933 0.0709859131601785 no 311 0.0788057162213265 493 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2935 9038016 29.96 µM 1.41314090196967 0.07098725390224 no 312 0.0788071494585149 491 6463195
SGTC_1884 5633444 25 µM 1.40637776536634 0.0719218692606566 no 313 0.0798059895679447 518 5724239
SGTC_584 0986-0246 15.4 µM 1.40528648229197 0.0720735565776605 no 314 0.0799680531840961 525 53315 YDR232W HEM1
SGTC_2040 5100729 123 µM 1.40451784683517 0.0721805433002974 no 315 0.0800823505189597 484 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1349 flufenamic acid 69 µM 1.40304049700981 0.072386518065952 no 316 0.0803023815697548 453 3371 A non-steroidal anti-inflammatory.
SGTC_1093 fluphenazine 7.97 µM 1.40257656033065 0.0724512937817058 no 317 0.0803715727683779 512 6602611 An atypical antipsychotic.
SGTC_406 estrone 100 µM 1.40232826039947 0.0724859801259155 no 318 0.0804086225516818 488 5870 A steroid.
SGTC_1195 1502-0147 41.1 µM 1.4020537519763 0.0725243424791919 no 319 0.0804495980221693 505 817940
SGTC_1305 1181-0477 144 µM 1.40163465713344 0.0725829406738211 no 320 0.0805121861204375 462 6252086
SGTC_265 mycophenolic acid 32.932 µM 1.39754892887934 0.0731561121480672 no 321 0.0811242819207889 520 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_336 4111-0029 111 µM 1.39721640596197 0.0732029125122722 no 322 0.0811742523339609 405 3131175
SGTC_455 paf C-16 10 µM 1.39377129012459 0.073689138357314 no 323 0.0816933402184056 452 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_203 k066-0004 30.888 µM 1.39210609083572 0.0739250392553376 no 324 0.0819451370569192 583 6795412
SGTC_2805 7950783 58.44 µM 1.38571871237271 0.0748352633765348 no 325 0.0829164060176847 555 1178958 YDL195W SEC31
SGTC_939 1165-0479 45.3 µM 1.3774416994802 0.0760274550270923 no 326 0.0841878640128914 510 1377347
SGTC_2728 chlorpromazine 9.18 µM 1.37679523324289 0.0761211750763268 no 327 0.0842877825095486 379 2726 A thorazine and dopamine antagonist.
SGTC_2095 5432005 200 µM 1.37674904459168 0.0761278745411242 no 328 0.0842949248807973 441 783734
SGTC_3334 9142812 21.919 µM 1.37543561862351 0.0763185692164651 no 329 0.0844982163430087 489 45283678
SGTC_414 piperonyl butoxide 100 µM 1.37321592555802 0.0766416696006254 no 330 0.0848426151098191 471 5794 A potent inhibitor of cytochrome P450.
SGTC_1682 st012968 530 nM 1.3698699079552 0.0771306833172614 no 331 0.0853637573581812 452 24207270
SGTC_435 c-PAF 6.7 µM 1.3688944175285 0.0772736947011395 no 332 0.0855161405113985 517 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_266 formosanin C 406 nM 1.36412908661673 0.0779752111267662 no 333 0.0862634708914542 530 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.3606638470205 0.0784883648116385 no 334 0.0868099723002759 538 66535 A nucleotide analog.
SGTC_3267 9137951 49.47 µM 1.35933969748268 0.0786851275290143 no 335 0.0870194850913405 422 16643986
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.35838736916039 0.078826870208567 no 336 0.0871704000211592 530 688801
SGTC_1391 3442-0225 151 µM 1.35832332337842 0.0788364095950645 no 337 0.0871805563294051 438 5227075
SGTC_505 gw-5074 63.9 µM 1.35619741522278 0.0791535524708681 no 338 0.0875181821112298 515 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1477 0139-0234 16 µM 1.35609111814002 0.079169435186827 no 339 0.0875350892453918 487 620880
SGTC_625 k213-0058 121 µM 1.35063630224262 0.07998772705804 no 340 0.0884059829927302 703 3655420
SGTC_2191 5911152 200 µM 1.35063295974875 0.0799882304277949 no 341 0.0884065186138187 493 2875902
SGTC_1836 st055642 81 µM 1.35054330276776 0.0800017333994968 no 342 0.0884208866838171 526 8571
SGTC_854 0422-0053 192 µM 1.348367822104 0.0803299045927083 no 343 0.0887700540565046 497 3596728
SGTC_1414 3917-0015 5.4 µM 1.33556195980114 0.0822823167297608 no 344 0.0908462453643771 479 6618702
SGTC_34 0469-0683 81.75 µM 1.3349374619832 0.082378435087431 no 345 0.0909484077353369 500 3690923
SGTC_1906 st060206 94.7 µM 1.33449935749327 0.0824459155242652 no 346 0.0910201286426786 545 5133468
SGTC_790 1575-0012 79.1 µM 1.33120260581172 0.0829550436679358 no 347 0.0915611771150369 534 378741 YLR208W SEC13
SGTC_107 0358-0022 2.6945 µM 1.32990108621634 0.0831566914500076 no 348 0.0917754317507171 373 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2511 berberine 10.47 µM 1.3264783001984 0.0836887515099767 no 349 0.0923406590968601 512 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2717 st081029 62.2815 µM 1.32265712965964 0.0842857558507436 no 350 0.0929747131375702 491 5292846
SGTC_1249 0481-0015 10.2 µM 1.32027102458896 0.0846601689928469 no 351 0.0933722730430241 459 4227577
SGTC_692 k241-0027 77.8 µM 1.31984736605826 0.0847267771226979 no 352 0.0934429918190899 508 3600480
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.31613954812025 0.0853114028690492 no 353 0.0940636045950485 543 16623 A steroid.
SGTC_2022 5136654 200 µM 1.30867734287714 0.0864971500352129 no 354 0.0953218348304528 532 1713771
SGTC_1489 4065-0444 182 µM 1.30823888898114 0.0865672018565862 no 355 0.095396147749837 521 2877968
SGTC_740 k014-0057 261 µM 1.30734321775131 0.0867104351245497 no 356 0.0955480863032959 598 4012779
SGTC_2959 9079155 11 µM 1.30620235774998 0.0868931346837076 no 357 0.0957418756233538 470 16189457
SGTC_2112 5488546 200 µM 1.30447781619607 0.0871698518666181 no 358 0.0960353592088638 552 600757
SGTC_824 1304-0008 100 µM 1.30245416916984 0.0874954015483279 no 359 0.0963805876720752 588 768245
SGTC_2589 lobaric acid 100 µM 1.30212143877203 0.0875490155542437 no 360 0.0964374377308291 530 73157 A novel microtubule depolymerizer.
SGTC_2196 6573537 42.6665 µM 1.30146584022267 0.0876547261642153 no 361 0.0965495248897725 511 2903087
SGTC_2862 9027634 71.43 µM 1.3013387322651 0.0876752324368483 no 362 0.0965712675077564 517 5012562
SGTC_1771 st048882 4.1505 µM 1.2985575863855 0.0881248098677165 no 363 0.0970479007873511 548 4580403
SGTC_3119 9125183 49.47 µM 1.29848406298878 0.0881367183363296 no 364 0.097060524625956 406 22695334
SGTC_2987 9018338 71.43 µM 1.29328556063491 0.0889817557400012 no 365 0.0979561564010334 560 5055682
SGTC_3210 9128157 49.47 µM 1.29262964491519 0.0890888045166594 no 366 0.0980695907336474 535 17590849
SGTC_1757 st041620 31.8375 µM 1.29105853409267 0.0893456074859381 no 367 0.0983416905955381 568 5289815
SGTC_204 PMA1.184 62.41 µM 1.28743778250256 0.0899395268738372 no 368 0.098970871188365 606 2252213 YGL008C PMA1
SGTC_2481 5478948 45.16 µM 1.28686981505405 0.0900329573519706 no 369 0.0990698339003824 548 77792
SGTC_651 3253-0966 34.4 µM 1.27872145964472 0.0913813082064757 no 370 0.100497579998619 584 781462
SGTC_1935 st074532 41.6 µM 1.27849675536699 0.0914187021376354 no 371 0.100537164040718 654 2829742
SGTC_1985 st071382 65.5 µM 1.27816882386959 0.0914732948737345 no 372 0.100594953063843 554 6123237
SGTC_2072 5231554 129 µM 1.27763361861262 0.0915624456167481 no 373 0.100689320498326 555 789545
SGTC_1348 1493-0373 93.8 µM 1.27622209915283 0.0917978754525152 no 374 0.100938509381272 550 3010129
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.27613342575175 0.0918126804024125 no 375 0.100954178731595 541 688662
SGTC_1421 4029-0249 71.4 µM 1.27519656820123 0.0919692066189349 no 376 0.101119837844619 601 2894095
SGTC_1153 4055-0057 267 µM 1.27197165029769 0.0925095232322675 no 377 0.101691596097552 582 882706
SGTC_1667 st014849 34.6 µM 1.27179153747477 0.0925397692079144 no 378 0.101723598261431 592 5348460
SGTC_590 k048-0076 22.4 µM 1.26650881275104 0.09343014321978 no 379 0.102665488156213 569 6832814
SGTC_3113 9123498 49.47 µM 1.26649984675265 0.0934316597493546 no 380 0.102667092130252 553 8897275
SGTC_1402 3909-7673 35.9 µM 1.26557985780019 0.0935873654619068 no 381 0.10283177056566 558 5328014
SGTC_1488 4013-0813 75.9 µM 1.26557824368058 0.0935876388156981 no 382 0.102832059662366 505 2910057
SGTC_973 1325-0077 65.9 µM 1.26494054290247 0.093695680619211 no 383 0.102946321197006 616 2835149
SGTC_2247 cerulenin 830 nM 1.26205466256868 0.0941857694288085 no 384 0.103464558811226 576 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2934 9036370 36.88 µM 1.26189704470402 0.0942125909241155 no 385 0.103492917783581 599 6462800
SGTC_722 3534-0461 190 µM 1.26145250264015 0.0942882680505891 no 386 0.103572931216875 573 658262
SGTC_2671 danthron 100 µM 1.26040170170027 0.0944673305774251 no 387 0.103762244053645 564 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3347 9188721 44.724 µM 1.26020698428981 0.094500539061921 no 388 0.103797351992377 532 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2932 9016711 44.54 µM 1.25950932162604 0.094619594052299 no 389 0.103923212711547 621 7117328
SGTC_364 0083-0097 67.7 µM 1.2562795535055 0.0951721895464291 no 390 0.104507316178277 580 5207356
SGTC_1415 3966-0071 78.1 µM 1.24017108983052 0.097963773318916 no 391 0.107456059542776 571 2893185
SGTC_2011 4012611 177 µM 1.23640491616155 0.0986250173862073 no 392 0.108154044824337 597 2049887
SGTC_3274 9138298 49.47 µM 1.2361575256976 0.0986685669206325 no 393 0.108200007687765 616 17015756
SGTC_2027 5150920 200 µM 1.23506911742811 0.0988603327353041 no 394 0.108402390893288 590 786715
SGTC_3043 9092303 49.47 µM 1.23121835351369 0.0995409849324441 no 395 0.109120604393741 545 25236084
SGTC_1137 ixabepilone 100 µM 1.2297808677704 0.0997959475049953 no 396 0.109389587269874 655 154225 A novel microtubule stabilizer.
SGTC_2147 5545932 89.7195 µM 1.22877464412708 0.0999747020260642 no 397 0.109578155371436 578 797404
SGTC_2536 dehydroabietamide 32.04 µM 1.2279014060907 0.1001300212142 no 398 0.109741990812263 644 3983547
SGTC_3136 9095672 49.47 µM 1.22735468396165 0.100227354019544 no 399 0.109844655359185 526 17217380
SGTC_1812 st052057 4.327 µM 1.22547595205876 0.100562350603394 no 400 0.110197972681533 620 3645418
SGTC_3160 9100216 49.47 µM 1.22524835543602 0.100602988750038 no 401 0.110240830158759 604 17191039
SGTC_22 0964-0034 14.468 µM 1.22096573633457 0.101369899622891 no 402 0.111049496553033 634 138402
SGTC_1457 k015-0032 57.3 µM 1.21954841674435 0.101624642006705 no 403 0.111318055544032 606 4302660
SGTC_3324 9138759 60.749 µM 1.21850810567462 0.101811919068689 no 404 0.111515473204981 595 45595710
SGTC_3147 9097027 49.47 µM 1.21788137984943 0.101924863602736 no 405 0.111634526520658 640 25236841
SGTC_1947 st076332 61.6 µM 1.21513901549659 0.102420147543573 no 406 0.112156537602085 542 24208416
SGTC_1497 4476-2978 41.3 µM 1.2138819591265 0.102647761896367 no 407 0.112396401504375 660 1528379
SGTC_1864 st057645 30.4 µM 1.21223826208365 0.102945939412644 no 408 0.112710594484034 566 688666
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.21011192397156 0.103332604070712 no 409 0.11311797414753 601 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1574 spiramycin 23.7 µM 1.20625981489995 0.104035775318592 no 410 0.113858663486379 621 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3253 9135987 49.47 µM 1.20554882026674 0.104165940019197 no 411 0.113995751581099 555 4182430
SGTC_2286 7945697 125 µM 1.20360826773664 0.104521805670967 no 412 0.114370511207457 617 1245733
SGTC_1904 st060225 78 µM 1.20331715509108 0.104575266862683 no 413 0.114426806477035 599 66595
SGTC_209 4077-0173 175.592 µM 1.20022005694754 0.105145258168291 no 414 0.115026943873125 505 15993494
SGTC_1671 st016596 74.5 µM 1.19793711509427 0.105566848891091 no 415 0.115470749642743 667 2829167
SGTC_1025 k007-0731 70 µM 1.19779598019109 0.105592952328469 no 416 0.115498226264557 601 6256118
SGTC_955 1216-0110 33 µM 1.1953265092676 0.106050445886276 no 417 0.115979743187042 664 3619719
SGTC_3031 9088762 49.47 µM 1.19101383353127 0.106852842449768 no 418 0.116824077124736 640 205253
SGTC_2030 5175110 200 µM 1.19036192101166 0.106974514395491 no 419 0.116952086440952 628 2831986
SGTC_207 4185-0010 4.486 µM 1.18336618454983 0.108286482375506 no 420 0.118332026478003 720 3761753
SGTC_1926 methyl fluorone black 53.6 µM 1.18176070916944 0.108589197239291 no 421 0.118650330998292 565 72721 Reacts with homocysteine.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.18159599586956 0.108620288580802 no 422 0.118683021546449 687 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_930 2810-3379 265 µM 1.1815891813447 0.108621575030873 no 423 0.118684374158109 714 1015764
SGTC_2148 5546263 113.568 µM 1.18109672434476 0.108714570370529 no 424 0.118782150537828 618 792097
SGTC_1299 1079-1439 3.74 µM 1.17751368871419 0.10939291321584 no 425 0.119495268571863 606 323161
SGTC_1901 st060216 58.6 µM 1.17620980688518 0.109640517963833 no 426 0.119755523286675 653 688792
SGTC_3350 9150499 3.57 µM 1.17285603341303 0.1102792412359 no 427 0.12042677168177 701 4910996 YPR165W RHO1
SGTC_3346 9158254 43.5805 µM 1.16617981024999 0.111558656109704 no 428 0.121770876861761 645 17639500
SGTC_424 splitomicin 100 mM 1.16551556086137 0.111686529773253 no 429 0.121905182585902 613 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1085 doxorubicin 7.67 µM 1.16052705512647 0.11265021110782 no 430 0.122917142504537 704 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_878 0828-0289 13.7 µM 1.15982907719876 0.112785518863048 no 431 0.12305920149275 699 745350 YLR208W SEC13
SGTC_855 0428-0020 25 µM 1.1571419163208 0.113307526455227 no 432 0.123607191869514 595 6812414
SGTC_1917 st066507 28.5 µM 1.15595759405281 0.113538139106217 no 433 0.123849251422508 684 3156428
SGTC_1383 3049-0032 20.7 µM 1.15522423520129 0.113681107291879 no 434 0.123999306354587 660 712864
SGTC_2776 terbinafine 19.92 µM 1.1543331889125 0.113854989247455 no 435 0.124181797365867 629 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3212 9128307 49.47 µM 1.15333404463998 0.114050191150725 no 436 0.124386650777497 563 27243542
SGTC_2772 vinpocetine 57.06 µM 1.15157287760818 0.11439484901104 no 437 0.124748315996199 638 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3355 9151058 44.0485 µM 1.1504280093425 0.114619295406949 no 438 0.124983814681688 642 17015728
SGTC_1511 0906-3109 28.5 µM 1.14914277890603 0.114871632368867 no 439 0.125248555571123 758 2882180
SGTC_1931 st074438 57.1 µM 1.14624113382492 0.115442782227087 no 440 0.125847696167584 637 2787313
SGTC_967 1306-0166 352 µM 1.14606908908709 0.115476710183759 no 441 0.125883283161941 664 4437607
SGTC_2621 lithochol-11-enic acid 100 µM 1.14504581277616 0.115678651036694 no 442 0.126095090138473 705 6708711
SGTC_1828 st055811 49 µM 1.14437528159634 0.115811114545683 no 443 0.126234017408388 620 5877589
SGTC_614 0462-0418 107 µM 1.14313417665082 0.116056579098254 no 444 0.126491443174938 606 5188303
SGTC_2683 piperine 63.03 µM 1.14155541466381 0.116369358518369 no 445 0.126819432790739 653 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1323 1348-1351 11.2 µM 1.1377704552995 0.117121657148213 no 446 0.12760817242542 641 6989654
SGTC_621 3584-0052 32.1 µM 1.13700968227337 0.117273283381223 no 447 0.127767119049074 711 2273927
SGTC_2157 5649910 96.377 µM 1.13661112763787 0.117352772979427 no 448 0.127850443089831 681 2858091
SGTC_1666 st014829 29 µM 1.13455074297097 0.117764314228857 no 449 0.128281800698063 694 3858230
SGTC_802 4112-3352 742 µM 1.13408020979475 0.117858441611498 no 450 0.128380452069919 732 704594
SGTC_3258 9138477 49.47 µM 1.13048221820726 0.118579958616327 no 451 0.129136543510149 669 4970355
SGTC_2890 9046729 58.44 µM 1.1259697482902 0.119489263584164 no 452 0.130089162192115 612 903329
SGTC_949 1165-0505 146 µM 1.12564006734483 0.119555889690717 no 453 0.130158950638906 734 6244267
SGTC_489 paxilline 115 µM 1.12507096131884 0.11967096350995 no 454 0.130279482690725 641 105008 A toxic potassium channel blocker.
SGTC_3124 9127567 49.47 µM 1.12502693362848 0.119679869208123 no 455 0.130288810616403 662 17592030
SGTC_2046 4110841 106 µM 1.12475953805335 0.119733966670136 no 456 0.130345472298888 681 44119630 YMR134W ERG29
SGTC_2686 alizarin 95.37 µM 1.12136313700024 0.120422601848426 no 457 0.131066660293395 635 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2908 7930301 100 µM 1.12075573567102 0.120546048580166 no 458 0.13119592523148 768 2223178
SGTC_1031 k035-0009 16 µM 1.11951301939099 0.120798892732156 no 459 0.13146066988308 747 5180959
SGTC_1090 efavirenz 20.7 µM 1.11652411626149 0.121408545456335 no 460 0.132098926583128 681 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1067 clotrimazole 1.36 µM 1.11522819522373 0.121673548303718 no 461 0.132376323289299 728 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3307 9126885 69.2785 µM 1.11123463473657 0.122492746801549 no 462 0.133233683373661 713 24824909
SGTC_2434 5670830 169.91 µM 1.11030293019992 0.122684422718624 no 463 0.133434255431893 692 1549830
SGTC_1051 3253-3903 78 µM 1.10892422094543 0.122968445009894 no 464 0.133731437019837 718 5509239
SGTC_311 1315-0136 58 µM 1.10826488294752 0.123104435371399 no 465 0.133873718425819 718 6759207
SGTC_18 0111-0177 500 nM 1.10669057586544 0.123429566974294 no 466 0.134213865650001 807 721752
SGTC_2198 6589944 200 µM 1.10561594307228 0.123651849190584 no 467 0.134446393093655 598 5290268
SGTC_1076 itraconazole 331 nM 1.10458251568864 0.123865872527154 no 468 0.134670265312466 712 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2104 5389443 200 µM 1.10180126812422 0.124443157820702 no 469 0.135274039479127 742 2244536
SGTC_2714 st079313 56.9 µM 1.10064264076137 0.124684200723458 no 470 0.135526109739024 689 2939799
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.09781835315999 0.125273137197619 no 471 0.13614190782579 784 5024745
SGTC_1802 st050112 57.9 µM 1.09569627524692 0.125716920906117 no 472 0.136605856642369 715 4662563
SGTC_1723 st034307 2.5525 µM 1.09503040144807 0.125856398860304 no 473 0.136751658886361 698 867466
SGTC_2443 5493264 126.67 µM 1.09402403438524 0.12606740334818 no 474 0.13697221865494 708 5340055
SGTC_283 0987-0079 11.7 µM 1.09135062244942 0.126629133717252 no 475 0.137559315353587 744 411556
SGTC_779 1360-0071 233 µM 1.09058661879806 0.12678998396218 no 476 0.137727410097829 776 7566
SGTC_724 3910-0327 137 µM 1.08656451122914 0.127639127861725 no 477 0.138614658087944 729 2885483
SGTC_545 4218-0007 221 µM 1.08451019632769 0.128074354996768 no 478 0.139069324284149 692 2840508
SGTC_3180 9109287 49.47 µM 1.08399060153135 0.128184599496069 no 479 0.13918448299543 662 18891271
SGTC_96 0929-0093 37.281 µM 1.0824467347843 0.128512556626927 no 480 0.13952703571295 687 6991579
SGTC_66 0109-0187 42.4 µM 1.0795172208288 0.129136460904628 no 481 0.140178610584423 660 759417
SGTC_2870 9038528 12.99 µM 1.07915818910426 0.129213068794086 no 482 0.140258607436174 645 6463316
SGTC_448 monastrol 171 µM 1.07767020507665 0.12953090109885 no 483 0.14059047977481 718 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2116 5511452 16.8835 µM 1.07689740262039 0.129696184661359 no 484 0.140763051808351 737 870744
SGTC_1614 st002383 48.6 µM 1.07530695766174 0.130036801466717 no 485 0.141118661101379 726 1947235
SGTC_259 usnic acid 108.925 µM 1.07508656578306 0.130084050376486 no 486 0.141167986772473 747 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1177 0983-0204 23.6 µM 1.07457417370049 0.130193945930476 no 487 0.141282709875466 774 766818
SGTC_2141 5621638 7.665 µM 1.07266347958996 0.130604309360718 no 488 0.14171106589075 737 2856238
SGTC_1257 0669-0121 16 µM 1.07248312108471 0.130643091444789 no 489 0.141751545618145 799 4307855
SGTC_2635 hydroquinidine 100 µM 1.07217809489295 0.130708698659218 no 490 0.141820023626547 743 442912 An experimental heart treatment.
SGTC_1697 st025554 27.742 µM 1.06977387985697 0.131226611687426 no 491 0.142360551097211 691 1269519
SGTC_1847 st056231 15 µM 1.06951755212121 0.13128191298385 no 492 0.14241826207039 780 5393180
SGTC_482 fipronil 114 µM 1.06778226197841 0.131656715530329 no 493 0.14280937059592 693 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1684 st024538 14.6195 µM 1.06750664021878 0.131716314524939 no 494 0.142871558382296 735 6732859
SGTC_134 0269-0018 6.916 µM 1.06667076250332 0.13189717413903 no 495 0.143060267100282 733 4378915
SGTC_644 1498-1197 63.3 µM 1.06489144013371 0.132282737956658 no 496 0.143462529530185 771 6741615
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.06258375563193 0.132783949497132 no 497 0.143985378464606 678 4620898
SGTC_1063 disulfiram 1.84 µM 1.0590111868151 0.133562461051104 no 498 0.144797342516812 718 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2696 st077691 74.316 µM 1.05794951962054 0.133794416617163 no 499 0.145039228608525 666 757133
SGTC_3060 1327-0027 12.5 µM 1.05773051981159 0.133842298645008 no 500 0.145089158486013 701 16000455 YPR107C YTH1
SGTC_2489 cantharidin 73.42 µM 1.05645739040731 0.134120888380086 no 501 0.145379648995495 737 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1792 st045773 43.6 µM 1.05632274009179 0.134150376215637 no 502 0.145410395079737 726 2919270
SGTC_1692 fluoroquinolonic acid 71 µM 1.05631215208184 0.134152695132784 no 503 0.145412812933853 723 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3063 1327-0034 4 µM 1.05575755195559 0.134274198545749 no 504 0.145539497976208 727 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3283 9109332 35.8195 µM 1.05360438406365 0.134746637023526 no 505 0.146032040594338 658 17027281
SGTC_927 2425-1185 123 µM 1.05269947226755 0.134945528736842 no 506 0.146239375306573 739 730375
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.04858543730843 0.135852295901713 no 507 0.147184480582045 720 279621
SGTC_2857 9024691 58.44 µM 1.04512772801084 0.136617623574609 no 508 0.147981970153736 715 16478292
SGTC_2780 5215298 71.43 µM 1.04449402007504 0.136758207236624 no 509 0.148128442224389 808 2834131
SGTC_1857 st056007 79.3 µM 1.04439790239773 0.136779538904001 no 510 0.148150666852091 739 619834
SGTC_2242 6630449 61.2675 µM 1.04430954107407 0.136799151188487 no 511 0.148171099999956 652 691249 YDR170C SEC7
SGTC_92 0063-0024 660.874 µM 1.04420677276096 0.136821963601865 no 512 0.148194867069382 833 3594437
SGTC_516 3992-2719 87.3 µM 1.04379160508113 0.13691414860331 no 513 0.14829090822468 704 5350887 YDR037W KRS1
SGTC_1298 1079-1278 263 µM 1.04212699141458 0.137284190354218 no 514 0.148676403050693 784 2840950
SGTC_3091 9116372 49.47 µM 1.0384548007073 0.138102927918263 no 515 0.149529183923698 716 17169793
SGTC_2873 9040596 71.43 µM 1.03688685706146 0.138453522957386 no 516 0.149894294902985 758 6463863
SGTC_579 4491-1009 110 µM 1.03488018424161 0.138903102807891 no 517 0.150362434933131 970 1271041
SGTC_3189 9110682 49.47 µM 1.0347789667547 0.138925806123577 no 518 0.150386073909224 759 17122418
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.0346186313763 0.138961774889513 no 519 0.15042352472156 738 6708514
SGTC_3158 9100007 49.47 µM 1.03350179959978 0.139212494741599 no 520 0.150684564392199 687 19297233
SGTC_331 k048-0133 24.5 µM 1.03329017996335 0.139260036336415 no 521 0.150734060712356 716 6813582
SGTC_799 1310-0557 151 µM 1.03249994596394 0.139437664693823 no 522 0.150918986475893 773 5354492
SGTC_2552 juarezic acid 87.02 µM 1.03248338101937 0.139441389801262 no 523 0.15092286451887 910 1549512
SGTC_770 0389-1121 67.2 µM 1.03135005595653 0.139696411516673 no 524 0.151188346385056 820 6753108
SGTC_1970 st070122 35.8 µM 1.02780134099237 0.140496996319364 no 525 0.152021642678937 749 102928
SGTC_1703 st026983 48.3 µM 1.02724771544553 0.140622173726367 no 526 0.152151917560212 821 1104023
SGTC_580 1123-0028 41 µM 1.02687511521404 0.140706463040138 no 527 0.152239636687191 856 1677248 YPR107C YTH1
SGTC_984 1492-0255 2.91 µM 1.02228879482918 0.141746785020292 no 528 0.153322117507344 734 1585198
SGTC_2651 TUB2.036 5 µM 1.02177721343129 0.141863149930877 no 529 0.153443178252404 944 15992207 YFL037W TUB2
SGTC_3076 9116187 49.47 µM 1.02065269475797 0.142119161595763 no 530 0.153709507110808 738 27241210
SGTC_2931 9014674 55.67 µM 1.01766385517862 0.142801130070103 no 531 0.154418864998271 748 2996810
SGTC_3050 9093513 49.47 µM 1.01505082787093 0.143399158318537 no 532 0.155040799677255 798 25236664
SGTC_2150 5556613 200 µM 1.01451858534446 0.143521176542839 no 533 0.155167682845635 821 743190
SGTC_3196 9111891 49.47 µM 1.01421896820954 0.143589895508883 no 534 0.155239139776445 760 18891510
SGTC_1356 1502-0781 85.8 µM 1.01327554705454 0.143806419781281 no 535 0.155464282045988 768 567702
SGTC_2907 7721985 69.9 µM 1.01318793863759 0.143826537931665 no 536 0.155485200239048 765 3267881
SGTC_2664 lyso-paf C-16 73.48 µM 1.01309996705927 0.143846741387929 no 537 0.155506207012285 824 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2961 9083290 32.55 µM 1.00906157639089 0.144776255275533 no 538 0.156472551961393 753 17741490
SGTC_3047 9092122 49.47 µM 1.0066320587658 0.145337400345027 no 539 0.157055811272675 757 17173831
SGTC_2541 muurolladie-3-one 83.07 µM 1.00013942980049 0.146844172959555 no 540 0.158621518353648 765 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1978 st071761 42 µM 0.998153883754648 0.147307052152858 no 541 0.159102372352338 762 5147680
SGTC_2810 7959871 45.46 µM 0.995663423465848 0.147889020280392 no 542 0.159706853728366 856 2974535
SGTC_1485 3909-9022 254 µM 0.993612170996379 0.148369509266518 no 543 0.160205858240153 835 714516
SGTC_1358 1509-0022 2.48 µM 0.993492405078918 0.148397595671469 no 544 0.160235024937078 827 3258434
SGTC_1933 st074711 15.9 µM 0.993141813231546 0.148479833696729 no 545 0.160320424821372 827 17250958
SGTC_2467 5474540 200 µM 0.99043462331139 0.149115883016864 no 546 0.160980864618844 811 5413519
SGTC_98 0074-0023 107.663 µM 0.988617726789069 0.14954377858378 no 547 0.161425104884711 843 3563821
SGTC_2570 licareol 100 µM 0.98843590563977 0.149586644168608 no 548 0.161469605024982 778 443158
SGTC_755 1995-0008 37.3 µM 0.987556280648557 0.149794137577753 no 549 0.161685003351668 843 689533
SGTC_2470 5664817 21.68 µM 0.985471937874108 0.150286576164897 no 550 0.162196154474822 814 2859561
SGTC_1961 st076550 68.7 µM 0.985278955980949 0.150332223808543 no 551 0.162243533302134 747 1579337
SGTC_2483 5729050 27.16 µM 0.983940231014565 0.150649138103816 no 552 0.162572450605313 911 2865180
SGTC_2416 tofa 880 nM 0.983274366529226 0.15080693273683 no 553 0.162736211266923 735 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2618 avocadyne 43.43 µM 0.981808846553249 0.151154614873002 no 554 0.163097014536545 809 3015189
SGTC_2985 9022375 71.43 µM 0.980333300396117 0.151505213993153 no 555 0.163460811061531 825 4939335
SGTC_144 4161-2749 112.381 µM 0.978878756187007 0.15185135167961 no 556 0.163819944979718 742 797501 YMR168C CEP3
SGTC_3310 9130229 44.1445 µM 0.975706380871104 0.152608102692987 no 557 0.164604994628787 806 7761258
SGTC_294 k038-0071 157 µM 0.974154586799486 0.152979183543891 no 558 0.16498989469942 824 24152826
SGTC_1068 loratadine 26.9 µM 0.971190779502231 0.153689580430291 no 559 0.16572664228366 788 3957 A H1 histamine antagonist.
SGTC_1015 4130-4525 82 µM 0.969570332105165 0.154078908553552 no 560 0.166130353499465 833 1363237
SGTC_1821 st053465 65.6 µM 0.96889943438212 0.154240289025199 no 561 0.166297683855273 784 675086
SGTC_2307 7538926 6.34 µM 0.968184828094831 0.154412306237615 no 562 0.166476035347635 830 96582
SGTC_125 0133-0007 11.75 µM 0.967112485435776 0.154670674218097 no 563 0.166743902307133 947 26541
SGTC_1097 itavastatin 7.23 µM 0.964597882431653 0.155277657118248 no 564 0.167373130230762 855 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2024 5144227 134 µM 0.96128242829397 0.156080351809689 no 565 0.168205090303428 884 3475211
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.961089045846923 0.156127255304012 no 566 0.168253698505091 674 6708630 An antioxidant.
SGTC_2627 acetyl isogambogic acid 100 µM 0.960615206479079 0.156242220822632 no 567 0.168372839954742 787 6857789 A caspase activator and apoptosis inducer.
SGTC_2888 9058547 12.99 µM 0.959245997958196 0.15657473907156 no 568 0.16871741648343 744 16476514
SGTC_1001 4048-4355 44.4 µM 0.957763879275219 0.156935202777066 no 569 0.169090918530865 823 21824233
SGTC_708 3448-5400 146 µM 0.954650575088143 0.157694161000659 no 570 0.169877216001578 843 3462195
SGTC_3305 9127027 53.8275 µM 0.952712441653135 0.15816785296694 no 571 0.170367893892031 854 41905295
SGTC_3171 9103192 49.47 µM 0.946837928886246 0.159609319857099 no 572 0.171860685602373 856 13018434
SGTC_368 fentichlor 4.58 µM 0.946455347467708 0.159703493572587 no 573 0.171958193465959 768 7329 A pesticide.
SGTC_178 4092-0806 87.505 µM 0.945558648018801 0.159924361631191 no 574 0.172186872080246 892 2169044
SGTC_380 3970-0968 6 µM 0.944468179386064 0.160193226489657 no 575 0.172465227589389 823 2891601
SGTC_1045 1348-1485 165 µM 0.944407904664705 0.16020809637751 no 576 0.172480621817796 962 6810614
SGTC_2236 dapsone 200 µM 0.94338034614668 0.160461735808848 no 577 0.172743196172675 926 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_758 0868-0029 16 µM 0.943116788769939 0.160526833766234 no 578 0.172810584622072 887 762687
SGTC_2600 tangeritin 87.95 µM 0.942380882445361 0.160708691960596 no 579 0.172998835704197 798 68077 A bioactive flavone.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.941344602553315 0.160965006919949 no 580 0.17326414632706 869 4213774
SGTC_917 harmaline 728.087 nM 0.939301547829144 0.161471120164602 no 581 0.173787972073697 848 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_727 3032-0951 202 µM 0.936132397251912 0.162258245019537 no 582 0.174602512231336 836 3652836
SGTC_3114 9122766 49.47 µM 0.934656752011398 0.162625603332358 no 583 0.174982610786444 790 17176985
SGTC_2189 6047310 154.431 µM 0.932831724043416 0.163080687445302 no 584 0.175453429389732 832 711535
SGTC_3174 9107204 49.47 µM 0.926246476874759 0.164729641786644 no 585 0.177158952069981 857 3938802
SGTC_546 peri-Naphthalide 147 µM 0.924671868881213 0.165125520278007 no 586 0.17756830829342 876 223824 A penicillin ester.
SGTC_552 k242-0005 476 µM 0.92083428385484 0.166092920068631 no 587 0.178568476332596 858 4088318
SGTC_3019 9081971 49.47 µM 0.920659410503154 0.166137090173346 no 588 0.178614136946932 943 16451803
SGTC_3325 9138760 55.175 µM 0.920609223786021 0.166149767905969 no 589 0.178627242395783 851 43844959
SGTC_1268 0828-0275 2.46 µM 0.917736883879202 0.166876394824344 no 590 0.179378316361947 938 745337
SGTC_227 fluconazole 33.516 µM 0.917588183312989 0.166914067905175 no 591 0.179417253319494 908 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_756 0508-1999 28.3 µM 0.917147441208053 0.167025761525245 no 592 0.179532692004396 845 6753853
SGTC_688 0527-0193 473 µM 0.916413148906403 0.167211954155432 no 593 0.179725120683897 868 4007154
SGTC_1096 rimcazole 32.2 µM 0.915405987874819 0.167467554943849 no 594 0.179989268031785 834 18528119 A dopamine reuptake inhibitor.
SGTC_2646 retinol 96.75 µM 0.913915147563004 0.167846367366831 no 595 0.180380716813935 879 445354 A vitamin A analog and teratogen.
SGTC_642 0335-0876 158 µM 0.913033870941695 0.168070553014594 no 596 0.180612363935075 902 6812350
SGTC_2084 5306078 60.6385 µM 0.911559366295992 0.168446079081008 no 597 0.181000360416224 861 679340
SGTC_2336 9001819 198.65 µM 0.909612951969467 0.168942616360262 no 598 0.181513332802188 927 2989602
SGTC_2655 perillic acid 100 µM 0.90864542336378 0.169189785867773 no 599 0.18176866067913 864 5702197 An apoptosis inducer.
SGTC_565 1418-0001 44.5 µM 0.908265350842002 0.16928694450628 no 600 0.181869022107299 942 2862145
SGTC_2346 9031566 143.75 µM 0.906747137781633 0.169675405299946 no 601 0.182270265000324 905 4771086
SGTC_1959 st077091 55.8 µM 0.899033605372429 0.171657867548231 no 602 0.184317380520995 945 821356 YKL052C ASK1
SGTC_1776 st049249 45.9 µM 0.896331746192504 0.172355760235366 no 603 0.185037804367651 936 1822314
SGTC_1944 st076371 56.9 µM 0.896071536252816 0.172423068123246 no 604 0.185107278990075 859 24208455
SGTC_2240 6690706 185.951 µM 0.89356256018553 0.17307291900153 no 605 0.185777992876457 798 805876
SGTC_214 4373-3496 70 µM 0.891758680041494 0.173541105513214 no 606 0.186261146762383 1066 3779166
SGTC_2953 9074162 66.49 µM 0.888874643608301 0.174291312956087 no 607 0.187035227087148 874 16451992
SGTC_860 0443-0016 25.1 µM 0.888234656157288 0.174458068094481 no 608 0.187207270242518 993 5337942
SGTC_1711 st032263 62.8 µM 0.885607848331352 0.175143570314486 no 609 0.187914440451542 905 3958979
SGTC_2389 9091542 195.52 µM 0.883906277270846 0.175588529608902 no 610 0.188373404172221 916 3626624 YOL127W RPL25
SGTC_1676 st018489 23.4 µM 0.882031810895569 0.176079529345096 no 611 0.188879802498746 908 3696235
SGTC_719 2810-4230 27.3 µM 0.881810458821311 0.176137567871972 no 612 0.188939657413851 929 721079
SGTC_704 1310-0270 142 µM 0.880753673419171 0.176414823951644 no 613 0.189225579502449 968 5718033
SGTC_2051 5263410 176 µM 0.877090477722666 0.177378028292622 no 614 0.190218748182431 981 227584
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.874723964556284 0.178002043581587 no 615 0.190862058743585 1134 16725076
SGTC_244 nsc-207895 1.295 µM 0.87390610706743 0.178218022234756 no 616 0.191084694302966 832 42640
SGTC_1965 Pectolinarigenin 58.4 µM 0.873643021350246 0.178287532635643 no 617 0.191156344820082 958 5320438 An anti-inflammatory.
SGTC_1702 st027038 51 µM 0.87277934109064 0.178515847401321 no 618 0.191391681038031 954 5521182
SGTC_581 0958-0271 211 µM 0.872213379579096 0.178665559743239 no 619 0.191545990887303 1011 4591145
SGTC_2630 antimycin a 100 µM 0.872124028541179 0.178689202767266 no 620 0.191570359481992 1008 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1458 k015-0034 6.33 µM 0.868130855278868 0.179747840210836 no 621 0.192661350682729 913 3598957
SGTC_2334 9017922 200 µM 0.867476330024807 0.179921737703394 no 622 0.192840537708046 969 3163164
SGTC_550 4123-0385 25.7 µM 0.867272624591042 0.179975880717585 no 623 0.192896326178348 933 5731123
SGTC_1632 st005650 90 µM 0.866055844626782 0.180299502583831 no 624 0.193229768959057 913 2759605
SGTC_531 3788-1495 174 µM 0.865260489106118 0.180511237189031 no 625 0.193447915848301 892 2896655
SGTC_2656 pseudo-anisatin 100 µM 0.860375010826696 0.181815237810896 no 626 0.194791178092974 974 6708809 A neurotoxin.
SGTC_1328 1441-0025 69.2 µM 0.856490752592428 0.182856192939239 no 627 0.195863192851787 912 4562601
SGTC_1981 st071826 47 µM 0.855679447493655 0.183074085972321 no 628 0.196087555743727 900 11838600
SGTC_1443 4112-3303 14 µM 0.851244002790538 0.184268179344851 no 629 0.197316912005574 981 704433
SGTC_753 1322-0200 289 µM 0.85062883887898 0.184434173282982 no 630 0.197487782140217 987 5403907
SGTC_2424 5537928 59.2 µM 0.850405558685065 0.184494445524899 no 631 0.197549823370663 1003 5382802
SGTC_2937 9044753 11.33 µM 0.84902921373146 0.184866246454901 no 632 0.197932518362803 1023 6465530 YGL099W LSG1
SGTC_3207 9114163 49.47 µM 0.846942452061721 0.185430844341673 no 633 0.198513599345667 1009 849233
SGTC_594 1487-1584 10.8 µM 0.8463636069446 0.185587647125393 no 634 0.19867496706437 998 5013332
SGTC_853 0419-0306 21 µM 0.845481951781263 0.185826635872624 no 635 0.198920902683677 897 762713
SGTC_1354 1498-1681 81 µM 0.843718480759805 0.186305229323525 no 636 0.199413368960163 1010 5754243
SGTC_1668 st014914 51.6 µM 0.842906160965956 0.186525943806323 no 637 0.199640463798671 1003 2839556
SGTC_3122 9126309 49.47 µM 0.841543109024502 0.186896660738348 no 638 0.200021872617651 1049 17591206
SGTC_86 0417-1630 471.922 µM 0.841499297473543 0.186908583971071 no 639 0.200034139216184 1088 3634867
SGTC_3097 9117246 49.47 µM 0.839520416523145 0.187447623440326 no 640 0.200588668599697 1024 16423892
SGTC_1044 1222-0021 1.78 µM 0.839446196689121 0.187467859310884 no 641 0.200609484700723 951 4306703
SGTC_873 0591-4978 488 µM 0.838112344401221 0.187831761267157 no 642 0.200983805283745 1048 3305145
SGTC_2975 9084847 53.72 µM 0.836988990354435 0.188138573190631 no 643 0.20129937829343 972 27211724
SGTC_3022 9087993 49.47 µM 0.836581301728403 0.188249998089508 no 644 0.201413979746758 998 17173644
SGTC_880 0833-0487 87.2 µM 0.836355565553768 0.188311711288058 no 645 0.201477451101292 961 76075
SGTC_2746 daunorubicin 9.88 µM 0.836009770376812 0.188406271184316 no 646 0.201574703277903 875 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_591 4299-0174 154 µM 0.835330330923786 0.188592153523336 no 647 0.201765872185199 986 5509088
SGTC_175 3793-3120 23.7 µM 0.833513001395101 0.189089897415027 no 648 0.202277734195269 964 5322297
SGTC_2817 7995342 71.43 µM 0.833274208173392 0.189155359987005 no 649 0.202345049458989 957 18879975
SGTC_2757 clomiphene 4.22 µM 0.831405024343528 0.189668258499094 no 650 0.202872430836673 1071 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2304 7443016 91.4 µM 0.825393372162961 0.191323629946218 no 651 0.204574148267487 930 939854
SGTC_1839 st053978 48 µM 0.82397874296142 0.191714446159946 no 652 0.204975818172987 1016 3788398
SGTC_804 1595-0054 20.9 µM 0.822320476260084 0.192173193437551 no 653 0.205447262948434 957 761523 Stimulates phospholipase C.
SGTC_3322 9139058 2.11 µM 0.82222505979418 0.19219961011679 no 654 0.205474409400973 993 4908926 YPR165W RHO1
SGTC_1780 st038448 24.544 µM 0.821937928754216 0.192279117642329 no 655 0.205556112437736 1004 728868 YDL195W SEC31
SGTC_3155 9099265 49.47 µM 0.821341303370711 0.19244438948036 no 656 0.205725943645917 927 25236499
SGTC_114 0364-0001 490.298 µM 0.820553354281206 0.192662793156079 no 657 0.205950363283325 994 4003655
SGTC_1545 lovastatin 49.4 µM 0.820440371949744 0.192694122003325 no 658 0.205982554233519 1053 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2341 7987486 176.74 µM 0.820104278518987 0.192787335683405 no 659 0.2060783316873 1054 1258686
SGTC_131 0141-0277 33.849 µM 0.820097779519903 0.192789138416814 no 660 0.206080183984866 989 1547771
SGTC_691 1548-0686 185 µM 0.819435049733201 0.192973024658978 no 661 0.206269122249413 1019 46495133
SGTC_3356 9151811 4.48 µM 0.818701983940085 0.193176551606223 no 662 0.206478232222027 991 1859254 YPR165W RHO1
SGTC_1957 st077035 62.4 µM 0.818675205295644 0.193183988856347 no 663 0.206485873315211 1050 705593
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.817378203375007 0.193544415244154 no 664 0.206856163975004 1103 6708784 An antioxidant flavonoid
SGTC_3231 9132313 49.47 µM 0.817236374709708 0.193583853150168 no 665 0.206896679515273 1005 4905967
SGTC_212 3807-4682 38.772 µM 0.815951485115002 0.193941362139926 no 666 0.207263941958192 1146 3125501 YBL034C STU1
SGTC_2224 6650123 117.647 µM 0.815700626256166 0.194011208281 no 667 0.20733569037973 998 2908370
SGTC_906 1165-0455 526 µM 0.815297906341648 0.194123368846119 no 668 0.207450903456678 986 3252859
SGTC_3187 9109394 49.47 µM 0.814790837867016 0.194264647443417 no 669 0.20759602314692 1021 17098090
SGTC_159 3970-0959 50 µM 0.814609850739253 0.194315088942757 no 670 0.207647835005451 1172 6615653
SGTC_2685 mycophenolic acid 18.85 µM 0.814374643169523 0.194380653710417 no 671 0.20771518016671 1012 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_671 0560-0003 407 µM 0.814346970697833 0.194388368374673 no 672 0.207723104259368 982 3238678
SGTC_3021 9087658 49.47 µM 0.81342172433762 0.194646420287874 no 673 0.207988154031205 1019 25237042
SGTC_2264 7948757 110.76 µM 0.813265725570753 0.19468994898742 no 674 0.208032861722944 1044 2971411
SGTC_530 4358-1714 28 µM 0.812820809783243 0.194814127404782 no 675 0.208160401310769 1041 1564641
SGTC_2677 mitomycin C 100 µM 0.812581830089813 0.194880847820645 no 676 0.208228926289504 1016 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_877 0771-0151 33.1 µM 0.812517568628813 0.194898791261099 no 677 0.208247354875559 1025 6166523
SGTC_1185 1319-0113 81.3 µM 0.810599773738902 0.19543475084673 no 678 0.208797773424149 1001 4672763
SGTC_2015 5119600 184 µM 0.81038565328817 0.195494645862095 no 679 0.208859280422175 1030 2828786
SGTC_1098 clofazimine 15.1 µM 0.809833205941005 0.195649231118727 no 680 0.209018022534128 1033 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_796 1234-0020 70.7 µM 0.809345164176221 0.195785856189383 no 681 0.209158317222155 1037 46495034
SGTC_534 k292-0788 63.4 µM 0.806219129250989 0.196662347974363 no 682 0.210058255346697 1099 4146317
SGTC_2592 piperlongumine 83.33 µM 0.805968436992217 0.196732741001272 no 683 0.210130524254938 995 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_673 1082-0474 110 µM 0.804090573800971 0.19726051993373 no 684 0.210672334030268 1118 3098046
SGTC_789 1309-1135 70.6 µM 0.801057658719159 0.198114736232668 no 685 0.211549133431739 1081 3092424
SGTC_3016 9080866 49.47 µM 0.79925661680456 0.19862305246175 no 686 0.212070814444006 1074 17066299
SGTC_2061 5245884 80.95 µM 0.799072111997545 0.198675170470492 no 687 0.21212429965272 1064 573863
SGTC_2099 5377090 177.372 µM 0.798527875100593 0.198828951860295 no 688 0.212282111798024 1012 2243829
SGTC_1805 st050013 60.3 µM 0.797862554784618 0.199017044430471 no 689 0.212475127638852 1005 4037144
SGTC_2082 5219693 150 µM 0.796262899506818 0.1994697212364 no 690 0.212939622440102 1075 2834649
SGTC_1846 st056244 14.8 µM 0.795675390467029 0.199636132375893 no 691 0.213110367173564 1051 5393182
SGTC_662 k832-1615 104 µM 0.79278763162961 0.200455299878886 no 692 0.213950781892835 1005 5878478
SGTC_2251 lansoprazole 556 µM 0.791501846316705 0.20082068587958 no 693 0.214325599582365 877 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_233 rapamycin 362 pM 0.791414245264304 0.200845594304505 no 694 0.214351149946263 1092 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2732 terfenadine 20 µM 0.790588092291548 0.201080593267817 no 695 0.21459219888666 1050 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2385 9074692 200 µM 0.790241631090399 0.2011791931131 no 696 0.214693333706527 1031 17046906
SGTC_29 0299-0004 12.984 µM 0.789914897421599 0.201272205231658 no 697 0.214788735273521 960 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3135 9127742 49.47 µM 0.789641606289613 0.201350023521921 no 698 0.214868551295946 974 3643468
SGTC_1719 st032227 49.2 µM 0.788986235222966 0.201536710637919 no 699 0.215060025829647 1094 3125804
SGTC_2881 9058953 51.95 µM 0.787974989013431 0.201824974711594 no 700 0.215355667850349 1086 17122249
SGTC_2160 5660466 132.927 µM 0.787270302667187 0.20202599725035 no 701 0.215561825166441 1005 2859134
SGTC_1694 st024011 44.9 µM 0.78663841589895 0.202206354460768 no 702 0.215746782115938 1109 2787533
SGTC_3327 9140648 26.9345 µM 0.785800779353377 0.20244558652633 no 703 0.215992104970726 1058 8029710
SGTC_1459 k035-0031 35.7 µM 0.784073568207198 0.202939418307635 no 704 0.216498471902549 932 3877128 YMR208W ERG12
SGTC_456 gingerol 170 µM 0.782111346508821 0.203501314695005 no 705 0.217074569528722 1143 442793 A herb.
SGTC_931 2812-0076 566 µM 0.781541115595901 0.203664778307761 no 706 0.217242152188864 1113 3450959
SGTC_2726 cimetidine 79.27 µM 0.779636203503441 0.204211411823118 no 707 0.217802519914318 1091 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1936 st074407 74.3 µM 0.778819818972098 0.204445948715377 no 708 0.218042930633953 1126 809813
SGTC_302 1094-0063 18.9 µM 0.776885963310732 0.205002160170163 no 709 0.218613026701494 1020 5440289
SGTC_2771 fluoxetine 41.05 µM 0.774608414017957 0.2056583762677 no 710 0.219285541961473 1049 3386 A selective serotonin reuptake inhibitor.
SGTC_842 0271-0008 11.1 µM 0.77407380774588 0.205812589528025 no 711 0.219443572756607 1096 1221709
SGTC_2202 7226349 200 µM 0.772688560239257 0.206212499020855 no 712 0.219853359265712 1058 844334
SGTC_2580 diallyl disulphide 81.36 µM 0.771200193206829 0.206642691199584 no 713 0.220294139852354 1028 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1369 1866-0067 208 µM 0.771071331113238 0.20667996201194 no 714 0.220332326238759 1109 3531355
SGTC_1896 st058441 89 µM 0.770667665187637 0.206796740161112 no 715 0.220451971258688 995 688759
SGTC_905 2-aminofluorene 215 µM 0.769350150975454 0.207178160883492 no 716 0.220842736371776 1154 1539 An established DNA mutagen. YPR165W RHO1
SGTC_825 1988-2224 89.6 µM 0.769193911316186 0.207223419888864 no 717 0.220889102205376 1054 1180859
SGTC_2617 dihydrotanshinone i 20.83 µM 0.767947347266283 0.207584729968173 no 718 0.221259233324781 1125 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2183 6420625 130.508 µM 0.766994697480211 0.207861101316186 no 719 0.22154233409606 1137 2897619
SGTC_3273 9137859 49.47 µM 0.766633713949315 0.207965882277309 no 720 0.221649662334524 1150 2377234
SGTC_1770 st043884 66.3 µM 0.766241455437907 0.208079776623697 no 721 0.221766322981699 1111 670149
SGTC_3015 9080845 49.47 µM 0.764283961862365 0.208648695342041 no 722 0.222349020397869 1138 5296973
SGTC_820 1582-0060 59.9 µM 0.763820614992117 0.208783494851189 no 723 0.222487075026537 1057 3848840
SGTC_3006 9075424 71.4286 µM 0.762957999495262 0.209034588523202 no 724 0.222744222278587 1073 7465181
SGTC_42 0133-0086 60.653 µM 0.76022675653749 0.209830782073663 no 725 0.22355952700564 1078 162923 Model of phenazepam hydroxylation.
SGTC_3269 9137823 49.47 µM 0.75941315262733 0.210068302578475 no 726 0.223802724032313 1013 17682936
SGTC_2041 5107442 45.335 µM 0.75905742437383 0.2101722021748 no 727 0.223909103167457 1118 793005
SGTC_121 0557-0495 61.343 µM 0.758863028524064 0.210228993240411 no 728 0.223967248621314 1245 3104427
SGTC_782 0083-0095 30.5 µM 0.757956666500158 0.210493898005293 no 729 0.22423846244172 1139 3591729 An indicator and reagent.
SGTC_613 3914-0030 117 µM 0.756978027556593 0.210780147188705 no 730 0.224531513200487 893 1145395
SGTC_675 1309-0189 238 µM 0.755399952420269 0.21124221040985 no 731 0.225004520889053 1094 4246530
SGTC_293 4049-0273 38.5 µM 0.752608066226937 0.2120611318237 no 732 0.225842734526245 1047 1380311
SGTC_2889 9059656 51.95 µM 0.750876032402227 0.212570107069349 no 733 0.226363632907051 1150 3949838
SGTC_3236 9132701 49.47 µM 0.750718765405236 0.212616356836715 no 734 0.226410963557088 1097 24282524
SGTC_767 0929-0023 86 µM 0.750099906411365 0.21279841065357 no 735 0.226597267943869 1205 1204563
SGTC_836 0330-0104 1.35 µM 0.749743623841341 0.212903261899554 no 736 0.226704564257101 1139 46494820
SGTC_597 k018-0003 82.8 µM 0.749478065075537 0.212981433429269 no 737 0.226784557279652 1201 6786234
SGTC_1934 st074720 32.6 µM 0.749400938882716 0.213004139912954 no 738 0.22680779262513 1161 17250992
SGTC_891 0929-0073 133 µM 0.748607356396733 0.213237858099375 no 739 0.227046948452142 1122 5603632
SGTC_1721 st082152 9.2685 µM 0.748334167138302 0.213318349727982 no 740 0.227129310276599 1095 5296051
SGTC_2284 7945075 39.21 µM 0.747915941751087 0.213441608659671 no 741 0.227255430600909 1196 1245402
SGTC_481 bay k-8644 50 µM 0.747698808977287 0.213505618162101 no 742 0.227320924864357 1072 2303 A calcium channel antagonist.
SGTC_1126 isoteolin 1.0172 µM 0.747164322869889 0.213663229268575 no 743 0.227482188453686 1129 133323
SGTC_129 0088-0017 176.636 µM 0.746926765272662 0.213733302823867 no 744 0.22755388431703 1058 182446
SGTC_710 3448-4187 58 µM 0.745976345364786 0.214013786820726 no 745 0.227840852222863 1140 3946412
SGTC_2280 7785178 200 µM 0.745488282147429 0.214157905242144 no 746 0.227988296166695 1089 2954328
SGTC_920 mycophenolic acid 780.421 nM 0.744795062568049 0.214362700578688 no 747 0.228197810091564 1079 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1898 st060199 18.6 µM 0.743377485795529 0.214781844543662 no 748 0.228626585574595 1164 688866
SGTC_1376 2910-0861 41.3 µM 0.743346790942646 0.214790925550283 no 749 0.228635874871012 1130 1112859
SGTC_2132 5317594 122.667 µM 0.74332942539603 0.214796063208933 no 750 0.228641130364241 1075 794577
SGTC_309 k408-0051 1.48 µM 0.742466208382099 0.215051538999322 no 751 0.228902459062106 1121 3640463
SGTC_487 nimodipine 119 µM 0.741850227836956 0.21523395105341 no 752 0.229089042295245 1046 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1480 1070-0044 41.2 µM 0.740530657019859 0.215625021373824 no 753 0.229489033125417 1129 3124987
SGTC_1029 k015-0030 64.7 µM 0.740515132715569 0.215629624634586 no 754 0.229493741210223 1085 2208316
SGTC_21 0849-0113 22.993 µM 0.74012003020235 0.215746799458611 no 755 0.229613582904982 1119 1560156
SGTC_246 cycloheximide 667 µM 0.730832344287233 0.218511844876467 no 756 0.232440782370127 1047 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2687 chenodiol 100 µM 0.729139192710671 0.219018104614123 no 757 0.232958261248393 1120 5702181 A cholesterol synthesis inhibitor.
SGTC_2468 5987765 72.9 µM 0.726146074632454 0.219914708314011 no 758 0.233874613045132 1173 26772094
SGTC_2444 5485484 36.41 µM 0.725880067714051 0.219994493824121 no 759 0.233956148364522 1166 6790631
SGTC_2382 9035899 200 µM 0.725007665505728 0.220256276679501 no 760 0.234223663893155 1189 6462679
SGTC_2071 5230951 39.92 µM 0.724364458502197 0.220449398972332 no 761 0.234421006851566 1208 1799272
SGTC_1615 st002656 86.5 µM 0.723418266855669 0.220733668426002 no 762 0.234711475959981 1162 1584458
SGTC_1019 4262-0212 3.4 µM 0.722986936553038 0.220863324945428 no 763 0.234843955023472 1226 4677213
SGTC_2217 6934799 96.0675 µM 0.719662375098941 0.221864139696378 no 764 0.235866448662828 1120 675606
SGTC_2406 ethylparaben 405.7 µM 0.718678976295122 0.222160674393546 no 765 0.23616936993852 1071 8434 A possible steroid mimic.
SGTC_2475 5812728 15.03 µM 0.715506883509376 0.223118729334595 no 766 0.237147944478654 1185 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_24 0417-1663 219 µM 0.71522548636806 0.223203832074985 no 767 0.237234861515285 1150 4329390
SGTC_3234 9132280 49.47 µM 0.714872018000938 0.223310757444175 no 768 0.237344064467926 1174 17612295
SGTC_3193 9111931 49.47 µM 0.713261314278736 0.223798369647838 no 769 0.237842035680354 1203 17087244
SGTC_2565 isoliquiritigenin 100 µM 0.712996980806928 0.223878449725203 no 770 0.237923812704984 1127 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2388 9080168 200 µM 0.712853723991551 0.223921856317379 no 771 0.237968138603312 1148 15943073
SGTC_2052 5265182 7.135 µM 0.711449339942818 0.22434763565661 no 772 0.238402916626888 1164 1239884
SGTC_2142 5622915 118.518 µM 0.709850777370012 0.22483284458499 no 773 0.238898338552062 1158 5322196
SGTC_501 nsc-95397 161 µM 0.709180697460861 0.22503640961239 no 774 0.239106175140693 1174 262093
SGTC_1724 st037281 8.293 µM 0.708205789877708 0.225332765334491 no 775 0.239408735584052 1183 574124 YDL195W SEC31
SGTC_2472 5377652 49.4 µM 0.706056459798418 0.225986906066093 no 776 0.240076513487405 1187 1610903
SGTC_276 colchicine 750 µM 0.705277830065759 0.22622414380879 no 777 0.240318677204943 1226 2833 A microtubule depolymerizer.
SGTC_236 1509-0011 5.31 µM 0.705179692511108 0.22625405495046 no 778 0.240349208669514 1274 3107280
SGTC_2258 7960471 200 µM 0.703589989692839 0.226738888300363 no 779 0.240844073562847 1145 2974708
SGTC_2575 plumbagin 510 nM 0.70343207650445 0.226787081227812 no 780 0.240893261234743 1148 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_166 k072-0058 166.424 µM 0.7024519022729 0.227086346120541 no 781 0.241198693510111 1208 5846229
SGTC_354 2783-3500 4.88 µM 0.70037837608193 0.227720164199871 no 782 0.241845518451356 1170 6740761
SGTC_1982 st072467 71.9 µM 0.699535357751462 0.227978135405397 no 783 0.242108762184764 1157 3163533
SGTC_2302 7771753 200 µM 0.696333869867583 0.228959315668113 no 784 0.243109883363454 1188 2203047
SGTC_1987 st072290 61.9 µM 0.695244516487562 0.229293716217334 no 785 0.243451039315622 1183 54697379
SGTC_450 aminopyrene 156 nM 0.694933393389795 0.229389272417757 no 786 0.243548522099197 1169 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1259 0671-0132 43 µM 0.694052051235742 0.229660082899445 no 787 0.24382478343871 1146 X1259
SGTC_1581 himbacine 57.9 µM 0.693947016782166 0.229692368831312 no 788 0.243857718316636 1197 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2222 6885208 172.143 µM 0.693625265913317 0.229791285784999 no 789 0.243958622300155 1166 609514
SGTC_2921 7974240 10.71 µM 0.690471411286815 0.230762147772551 no 790 0.244948891152249 1202 2979074 YDR527W RBA50
SGTC_2748 diazoxide 86.69 µM 0.68970929997001 0.230997094381813 no 791 0.245188508132937 1148 3019 A potassium channel activatior.
SGTC_3254 9136651 49.47 µM 0.685636806163149 0.232254839112669 no 792 0.246471082816742 1208 16454030
SGTC_2064 5220758 200 µM 0.683967558843298 0.232771466661939 no 793 0.246997825671433 1253 788518
SGTC_2155 5570423 76 µM 0.683945183135403 0.232778396217948 no 794 0.24700489057389 1173 797402
SGTC_338 4055-0136 114 µM 0.683690643057846 0.232857233065158 no 795 0.247085266627847 1183 2900563
SGTC_1798 st045719 60.953 µM 0.683385765324535 0.232951680149425 no 796 0.247181556201961 1163 3980186
SGTC_769 0302-0231 76 µM 0.683353639738965 0.232961633469388 no 797 0.247191703598384 1223 571869 YER009W NTF2
SGTC_2515 chrysin 20.77 µM 0.682114207591238 0.233345821235799 no 798 0.247583368736684 1214 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_10 0279-0212 42.575 µM 0.681091811140726 0.233662998696947 no 799 0.247906699141068 1238 39851 YBR002C RER2
SGTC_2944 9067346 25.62 µM 0.680699300636071 0.233784830471121 no 800 0.248030889480566 1161 6473075
SGTC_638 3970-0837 4.09 µM 0.68069638971539 0.233785734126543 no 801 0.248031810619968 1217 4118451 YLR208W SEC13
SGTC_1398 3558-0053 112 µM 0.679174175614016 0.234258549739978 no 802 0.248513753991249 1142 4532369
SGTC_2597 laccaic acid a 100 µM 0.678066108629161 0.234603059561982 no 803 0.248864889113012 1187 5491415 A textile dye.
SGTC_369 0957-0393 4.5 µM 0.677136587167248 0.234892273668329 no 804 0.249159648548465 1212 6997992
SGTC_91 0417-1751 58.384 µM 0.677133964563363 0.234893089951857 no 805 0.249160480461848 1311 6795624
SGTC_1732 st034308 51.822 µM 0.676767901502924 0.235007042189412 no 806 0.249276613428135 1142 830119
SGTC_2803 7707263 71.43 µM 0.676712969189822 0.235024144774398 no 807 0.249294043106646 1210 2199229
SGTC_1706 st031321 9.9705 µM 0.67547081625926 0.235411059247533 no 808 0.249688343364801 1237 6103185
SGTC_2537 larixol 68.93 µM 0.675427675227449 0.235424503431334 no 809 0.249702043698407 1231 6708759
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.672520815588033 0.236331353323733 no 810 0.250626096531472 1217 15053
SGTC_1837 st055472 66.5 µM 0.667982145564404 0.237751115075748 no 811 0.252072494770631 1293 676091
SGTC_1769 st044406 64.4 µM 0.667618602916282 0.237865038515333 no 812 0.252188539928839 1238 670903
SGTC_1529 apigenin 74 µM 0.665547295638174 0.238514695334558 no 813 0.252850251769772 1313 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2178 5812956 200 µM 0.664637075692453 0.238800488905832 no 814 0.253141324715606 1237 5403383
SGTC_2977 9011197 71.43 µM 0.664179044915825 0.238944373591311 no 815 0.25328786184017 1269 2704722
SGTC_396 dithiazanine 1.25 µM 0.662879364624476 0.239352910010728 no 816 0.253703909369979 1223 10578 An antihelmenthic.
SGTC_558 k064-0027 21.3 µM 0.662489693663473 0.239475471958749 no 817 0.253828718893581 1266 5088526
SGTC_883 0850-0245 24.6 µM 0.661623982206101 0.239747883979688 no 818 0.254106116945127 1295 6823229 YPR165W RHO1
SGTC_3077 9117319 49.47 µM 0.661196799024044 0.239882367295486 no 819 0.254243056897944 1253 17154678
SGTC_2801 7907800 81.82 µM 0.659106534804428 0.240541004941056 no 820 0.254913679816911 1279 6620925
SGTC_1371 2421-0008 32.7 µM 0.657782367486965 0.240958756068182 no 821 0.255338993076588 1241 2827552
SGTC_3 0833-0587 95.581 µM 0.65666043958856 0.241313012843403 no 822 0.255699638501326 1192 5382644
SGTC_1206 3978-0017 132 µM 0.656055330742918 0.241504197715115 no 823 0.255894262011137 1318 3873677
SGTC_872 0588-0139 234 µM 0.654557854946221 0.241977680485157 no 824 0.256376233140928 1272 2047100
SGTC_1531 st059297 52.4 µM 0.653693170616825 0.242251311795796 no 825 0.256654752023752 1273 7566702
SGTC_69 0096-0274 206.684 µM 0.653323325956378 0.242368401162216 no 826 0.256773928814727 1372 6741392
SGTC_2033 5192550 145 µM 0.652420855349811 0.242654243589966 no 827 0.257064857038988 1240 182073
SGTC_1660 st012960 28.1 µM 0.652355842883653 0.242674842243669 no 828 0.25708582163742 1240 24207266
SGTC_1735 st034310 56.75 µM 0.650452178148245 0.243278421915556 no 829 0.257700091227094 1341 871153
SGTC_1867 st057372 64 µM 0.649541373733987 0.243567490076296 no 830 0.257994256488552 1263 688837
SGTC_1116 jasmonic acid 1.58368 µM 0.649375025993704 0.243620305011491 no 831 0.258048001126757 1312 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1462 k081-0014 26.5 µM 0.647557506782805 0.244197764916843 no 832 0.258635594353368 1079 3270634
SGTC_2001 4023502 57.655 µM 0.647500746623177 0.24421581055877 no 833 0.258653955726034 1289 108941 YCR052W RSC6
SGTC_427 1354-0053 47.3 µM 0.644070366185477 0.245307757979759 no 834 0.259764902785572 1341 6813657
SGTC_196 k015-0023 18.111 µM 0.640187483905489 0.246546903991884 no 835 0.261025359406598 1280 5211998
SGTC_3159 9100096 49.47 µM 0.637641973183005 0.247361070136927 no 836 0.261853383189686 1244 25236875
SGTC_2411 st077133 39.94 µM 0.637159791098852 0.247515454884598 no 837 0.262010382800967 1417 1403142 YNL221C POP1
SGTC_419 nsc-638432 893 µM 0.631990314660533 0.249173844222599 no 838 0.263696603019523 1286 368090
SGTC_1607 st000305 50.6 µM 0.631397667046713 0.249364344892687 no 839 0.263890270522833 1331 5457690
SGTC_1266 0828-0227 32.9 µM 0.631170206139987 0.24943748048858 no 840 0.263964620260627 1286 3913820
SGTC_1804 st050076 49.1 µM 0.629834065492337 0.249867320383081 no 841 0.264401577602329 1313 3895976
SGTC_1617 st002906 78 µM 0.629491738576652 0.249977511075338 no 842 0.26451358780395 1317 5150859
SGTC_1645 Cervolide 78 µM 0.629354019051275 0.250021848516599 no 843 0.264558656778241 1237 23173 A fragrance.
SGTC_3008 9078912 71.4286 µM 0.628472952567559 0.250305597879087 no 844 0.26484707986343 1283 16648731
SGTC_1440 4100-1550 40 µM 0.627174313407996 0.250724138503482 no 845 0.265272489417691 1303 742806
SGTC_51 1013-0126 23.419 µM 0.626853767418923 0.250827504815765 no 846 0.265377547558455 1409 1627850
SGTC_1881 5652484 16 µM 0.626707724810655 0.250874606585849 no 847 0.265425419656528 1272 2255129
SGTC_3286 9117135 37.221 µM 0.626371302579233 0.250983127545638 no 848 0.265535713994836 1267 3438150
SGTC_1416 3966-0321 25.3 µM 0.625666969851248 0.251210407171223 no 849 0.265766701205583 1304 582530 YLR208W SEC13
SGTC_2377 9073351 62.6 µM 0.622922845105698 0.252096940010787 no 850 0.266667612372246 1264 7337946 YHR072W ERG7
SGTC_511 blebbistatin 171 µM 0.62209780709938 0.252363803903504 no 851 0.266938778418462 1370 3476986 A myosin inhibitor.
SGTC_634 1611-4317 11.2 µM 0.621927537773357 0.252418897152309 no 852 0.266994758337502 1323 2843522
SGTC_488 nitrendipine 139 µM 0.621903089599717 0.252426808253815 no 853 0.26700279671817 1342 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3144 9087057 49.47 µM 0.619640710919684 0.25315944886795 no 854 0.267747178843049 1266 17249618
SGTC_1378 2093-0007 380 nM 0.619428730004169 0.253228153267346 no 855 0.267816979685568 1332 3618014
SGTC_404 fumagillin 50 µM 0.61903788217217 0.253354855302508 no 856 0.267945701658123 1326 12015870 A methionine aminopeptidase binder.
SGTC_3057 9095946 49.47 µM 0.617430390256845 0.2538763097961 no 857 0.268475441013589 1333 24540043
SGTC_1204 4049-0315 18.3 µM 0.61740879745342 0.253883318120447 no 858 0.268482560375297 1409 588402
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.616982563206326 0.254021680729288 no 859 0.268623113464873 1262 2333 A French combination drug.
SGTC_2321 7390090 138.78 µM 0.615827447075287 0.254396849114425 no 860 0.269004205165946 1257 649046
SGTC_35 0133-0054 64.071 µM 0.615723481329703 0.254430630227574 no 861 0.269038518472697 1260 99677
SGTC_1964 st076914 61 µM 0.613196976730801 0.255252277920766 no 862 0.269873051783774 1315 24208661
SGTC_2396 5342950 42.78 µM 0.610831753431203 0.256022730487253 no 863 0.270655484743584 1340 1886677
SGTC_2960 9079389 5.97 µM 0.610112919247891 0.256257125117427 no 864 0.270893504558565 1347 16457355
SGTC_3345 9148410 3.559 µM 0.609939485114921 0.256313694586128 no 865 0.270950947571248 1297 4903596
SGTC_1346 1488-2224 62.4 µM 0.609394208850766 0.25649159117691 no 866 0.271131587769843 1329 3722427
SGTC_1741 st038134 10.228 µM 0.609234573236566 0.256543684527037 no 867 0.271184483533803 1407 1272587
SGTC_961 1252-1571 372 µM 0.609109427831768 0.256584526657065 no 868 0.271225954455636 1382 6813498
SGTC_2897 9048598 12.99 µM 0.609092867503072 0.256589931496728 no 869 0.271231442485655 1303 6467404
SGTC_3301 9125354 19.7965 µM 0.608755920763513 0.256699914599063 no 870 0.271343117375399 1320 41905162
SGTC_340 k038-0059 454 µM 0.60842392344261 0.256808306158724 no 871 0.271453174276697 1331 23733424
SGTC_748 act1.228 77.9 µM 0.60804678076442 0.256931465815625 no 872 0.27157822380858 1274 4421505 YNR035C ARC35
SGTC_250 brefeldin a 552.239 µM 0.607884016150477 0.256984627695588 no 873 0.271632200676023 1259 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1304 1165-0502 251 µM 0.60703813541176 0.257260999829585 no 874 0.271912802129509 1342 767425
SGTC_79 0052-0007 94.094 µM 0.606147838374176 0.257552050763047 no 875 0.27220829333566 1381 2801472
SGTC_2791 5663188 71.43 µM 0.60598196112056 0.257606297322009 no 876 0.272263365930081 1357 54690634
SGTC_592 k241-0073 46.5 µM 0.605322839277796 0.25782190744189 no 877 0.272482254425803 1365 4230158
SGTC_2989 9073649 71.4286 µM 0.604601746664451 0.258057896498854 no 878 0.272721822915476 1316 21367202
SGTC_1338 1486-1223 76 µM 0.603984622320036 0.258259949205064 no 879 0.27292693300654 1387 3444526
SGTC_3281 9140613 49.47 µM 0.602140364226374 0.258864266136195 no 880 0.273540354045224 1234 16013766
SGTC_366 0181-0206 4.31 µM 0.601825785343232 0.258967418707278 no 881 0.27364505461067 1386 274874
SGTC_1482 3346-2049 8.48 µM 0.598596551994086 0.260027534432272 no 882 0.274720977958565 1348 3826804
SGTC_8 0354-0001 70 µM 0.598433187029192 0.260081224451416 no 883 0.274775463653441 1385 4993152
SGTC_3089 9117425 49.47 µM 0.598327922981031 0.260115822587968 no 884 0.274810574277347 1264 9401657
SGTC_1670 st016595 4.04 µM 0.596314937389659 0.260777905942811 no 885 0.275482427017978 1338 597879
SGTC_2167 5876490 200 µM 0.594496372978018 0.261376787590261 no 886 0.27609008373645 1514 686534
SGTC_2628 lathosterol 100 µM 0.594435295826831 0.261396913502938 no 887 0.276110503525684 1383 6710616
SGTC_2405 ticlatone 3.52 µM 0.592709333717126 0.261965974868518 no 888 0.27668784693834 1234 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2415 st077333 57.7 µM 0.591970085139539 0.262209904257349 no 889 0.276935310295936 1484 2766255
SGTC_2407 paclitaxel 400 µM 0.590668852006605 0.262639553852263 no 890 0.277371160982027 1493 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_381 3461-2219 42.7 µM 0.590282878841123 0.262767066213529 no 891 0.277500507945942 1375 2883159
SGTC_2177 5811945 192 µM 0.59013845967866 0.262814785515397 no 892 0.277548913137466 1405 5343475
SGTC_1717 st033143 58.0435 µM 0.589183726075398 0.263130362178806 no 893 0.277869016416882 1428 674616
SGTC_1288 0973-0013 65.5 µM 0.588793713424175 0.263259332236609 no 894 0.277999831766544 1399 4315430
SGTC_150 3970-0969 77.2 µM 0.587465705572931 0.263698722169419 no 895 0.278445488225243 1406 6615640
SGTC_3330 9141424 71.43 µM 0.586708277849112 0.263949495113266 no 896 0.278699823659207 1392 27261020
SGTC_632 0781-2353 4.65 µM 0.584450787553683 0.264697636586258 no 897 0.279458532897824 1395 6811515 YHR007C ERG11
SGTC_1303 1160-0052 261 µM 0.584145488054471 0.264798896802854 no 898 0.279561216513326 1378 3562476
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.582746924661054 0.265263016950876 no 899 0.280031839592155 1306 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1825 st052143 62.6 µM 0.582263154472655 0.265423654550982 no 900 0.280194719859772 1406 674173
SGTC_3282 9108498 15.4605 µM 0.581917234650176 0.265538548710723 no 901 0.280311215516087 1342 16459645
SGTC_1103 duloxetine 36.1 µM 0.581849590058991 0.265561019202395 no 902 0.280333998973314 1468 60835 A selective serotonin reuptake inhibitor.
SGTC_303 1348-1668 34.2 µM 0.580692483661228 0.265945541430731 no 903 0.280723864198797 1373 5380509
SGTC_830 4076-0286 57.8 µM 0.580690897473641 0.265946068736033 no 904 0.28072439881479 1410 6866659
SGTC_1028 k015-0029 4.8 µM 0.580389232744325 0.266046362475423 no 905 0.280826082240107 1355 4588309
SGTC_1037 k284-1091 78.7 µM 0.580170616751057 0.26611905717346 no 906 0.28089978319866 1338 3334711
SGTC_1417 3966-0327 90.4 µM 0.579911146737579 0.266205349796677 no 907 0.28098726920855 1412 651118
SGTC_1389 3405-0187 19 µM 0.579891357914691 0.266211931598758 no 908 0.280993941984871 1313 799890
SGTC_1146 3579-1023 7 µM 0.578656073692796 0.26662295261173 no 909 0.281410630412848 1471 X1146
SGTC_1211 1056-0033 32.3 µM 0.576657926798942 0.267288482522044 no 910 0.282085279731492 1372 6741922
SGTC_2208 7283366 200 µM 0.572647976716041 0.268626615161305 no 911 0.283441534160135 1416 898663
SGTC_2800 7887935 81.82 µM 0.5715127118446 0.269006067074253 no 912 0.283826072977817 1415 2961002
SGTC_2865 9030313 51.95 µM 0.571509049461033 0.269007291627736 no 913 0.283827313910557 1318 42562754
SGTC_1317 1273-0028 910 nM 0.570454575632984 0.269359981519453 no 914 0.284184711372321 1370 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3034 9090421 49.47 µM 0.569851157799944 0.26956191094635 no 915 0.284389327196262 1348 17173761
SGTC_3202 9113761 49.47 µM 0.56974959142714 0.269595906857541 no 916 0.284423774741429 1516 4798415
SGTC_895 0964-0006 13.7 µM 0.569557739789418 0.269660128570925 no 917 0.284488849137447 1351 6738897
SGTC_310 1273-0058 1.06 µM 0.569043546380731 0.26983229093266 no 918 0.28466329410582 1376 2734232
SGTC_2352 9027995 87.8 µM 0.566296383871169 0.270753027959497 no 919 0.285596159111832 1399 2997347
SGTC_2666 tannic acid 100 µM 0.566068554252438 0.270829457549033 no 920 0.285673589416297 1415 16134267 A thiamine antagonist.
SGTC_2699 st077704 54.6 µM 0.565944806401398 0.270870975529091 no 921 0.285715650617167 1411 645852
SGTC_2009 4012297 12.05 µM 0.565286041699309 0.271092047601955 no 922 0.285939610618024 1385 45595307
SGTC_1515 3460-0031 42.1 µM 0.564879855085358 0.271228402890055 no 923 0.28607774331385 1351 2876596
SGTC_2090 5301565 104.445 µM 0.564554115675658 0.271337777058427 no 924 0.286188541071019 1413 2056344
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.564512499216294 0.271351752282913 no 925 0.286202698058059 1438 5377381
SGTC_1897 st060201 15 µM 0.564341625424327 0.271409137175803 no 926 0.286260828979732 1362 611878
SGTC_2745 rifampicin 24.3 µM 0.563515844049976 0.271686546201655 no 927 0.286541837136628 1402 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_93 0109-0045 59.227 µM 0.56347794375906 0.271699281630174 no 928 0.286554737505168 1414 88733
SGTC_387 norethindrone acetate 66.7 µM 0.563391266349339 0.271728408485402 no 929 0.286584241494402 1386 541197
SGTC_785 1270-0111 65.3 µM 0.563137672163869 0.27181363455167 no 930 0.286670570300112 1367 6741994
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.562167975673545 0.27213964563116 no 931 0.287000789100374 1438 364106
SGTC_3279 9140807 49.47 µM 0.561975398454403 0.272204413043774 no 932 0.287066390457704 1398 45595718
SGTC_1217 1183-1422 255 µM 0.561750212709072 0.272280157044449 no 933 0.287143108902226 1460 2849664
SGTC_1521 st012942 49.4 µM 0.561397569282778 0.272398794044719 no 934 0.287263270353805 1523 24207259
SGTC_1749 st037932 54.2 µM 0.561267797708968 0.272442458516582 no 935 0.287307495345661 1383 594497
SGTC_3123 9126162 49.47 µM 0.558596457209998 0.27334206068944 no 936 0.288218579213161 1434 25239884
SGTC_1472 k841-0093 193 µM 0.557099355055299 0.273846868119025 no 937 0.2887297740899 1452 X1472
SGTC_386 1509-0011 3.07 µM 0.554888776639451 0.274593094229365 no 938 0.289485369538758 1404 3107280
SGTC_2863 9028737 58.44 µM 0.553750590236974 0.274977703210822 no 939 0.289874773658758 1426 6460917
SGTC_968 1309-0633 340 µM 0.553297652765947 0.275130830859542 no 940 0.290029804034032 1402 3761976
SGTC_3285 9112818 20.8695 µM 0.552534152656355 0.275389047544467 no 941 0.290291221004463 1423 17017947 YPR165W RHO1
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.551773072599167 0.275646564385017 no 942 0.290551919147092 1441 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1285 0929-0069 65.5 µM 0.551370934413006 0.275782678482234 no 943 0.290689710609575 1413 1206237
SGTC_2262 9014885 67.46 µM 0.550786327741394 0.275980612663132 no 944 0.290890078853447 1372 6457424
SGTC_337 1315-0038 354 µM 0.550513519553201 0.276073003020907 no 945 0.290983603288192 1394 1626437
SGTC_913 3487-1245 167 µM 0.549575133391796 0.276390916694019 no 946 0.291305409201748 1349 4016153
SGTC_464 bw-b 70c 158 µM 0.54753211562864 0.277083686361102 no 947 0.29200660635636 1454 5353454
SGTC_2353 9059630 146.67 µM 0.546781818637591 0.277338318764299 no 948 0.292264317714886 1455 4779114
SGTC_966 1300-0360 30.2 µM 0.546357004158506 0.277482541099443 no 949 0.292410279516487 1415 70588
SGTC_3194 9111903 49.47 µM 0.544486393979171 0.278118039389872 no 950 0.293053404386966 1467 17087251
SGTC_2327 6189656 200 µM 0.542800205312911 0.2786914922731 no 951 0.293633685926476 1526 5349088
SGTC_2343 7990716 14.84 µM 0.542629829242506 0.278749467172369 no 952 0.293692348377344 1456 6456862
SGTC_2561 acetosyringone 100 µM 0.542553745459835 0.278775358558774 no 953 0.293718546655239 1384 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1900 st060200 72.8 µM 0.542531121736525 0.278783057659941 no 954 0.293726336994271 1427 688945
SGTC_1239 0337-0584 35.4 µM 0.542470890825477 0.278803555404062 no 955 0.293747077601674 1537 914301 YML130C ERO1
SGTC_850 0388-0143 75.9 µM 0.54232281399389 0.278853951932308 no 956 0.293798070968641 1404 67273
SGTC_598 3937-0236 20.2 µM 0.54227791215602 0.278869234717664 no 957 0.293813534668787 1457 1379313
SGTC_3248 9135562 49.47 µM 0.541666228841134 0.279077467776468 no 958 0.294024229182572 1442 17650701
SGTC_2785 7756463 72.73 µM 0.541189500576102 0.279239811001765 no 959 0.294188486802302 1370 2201551
SGTC_744 1594-0068 283 µM 0.54079179454278 0.279375279403658 no 960 0.29432554959263 1435 668392
SGTC_2404 5161160 200 µM 0.539475363940653 0.279823915464409 no 961 0.294779445792644 1445 2831543
SGTC_3277 9138724 49.47 µM 0.539431674185978 0.279838810806613 no 962 0.294794515250621 1395 15943418
SGTC_2135 5326629 150.42 µM 0.539201593646596 0.279917259532461 no 963 0.294873880425482 1397 5020077
SGTC_1478 0453-0656 35.7 µM 0.53689255800303 0.280705143004553 no 964 0.295670915931265 1438 5258496
SGTC_2028 5153890 36.43 µM 0.536375359157203 0.280881767252162 no 965 0.295849578845796 1397 2830968 YPR165W RHO1
SGTC_70 0141-0289 43.283 µM 0.536111826449788 0.280971784757157 no 966 0.295940633539567 1533 352408
SGTC_3121 9125696 49.47 µM 0.535381105816376 0.281221457216842 no 967 0.296193176286511 1475 1235365
SGTC_3075 9116269 49.47 µM 0.534585684482668 0.281493358316055 no 968 0.296468192426058 1468 17015205 YNL244C SUI1
SGTC_1138 3761-0006 1.03 µM 0.533155552489783 0.28198254310837 no 969 0.296962953273299 1448 12061087
SGTC_1865 st057639 52.2 µM 0.531945352308366 0.282396818568747 no 970 0.297381922509385 1431 688818
SGTC_3100 9120536 49.47 µM 0.531451651774654 0.282565906062406 no 971 0.297552918299551 1400 16421196
SGTC_1359 1582-0056 520 nM 0.531337588149414 0.282604978633252 no 972 0.297592431221414 1487 3661189
SGTC_2680 butyl paraben 22.24 µM 0.530733449260443 0.282811970105692 no 973 0.297801751647053 1459 7184 An antifungal and steroid mimetic.
SGTC_1265 0819-1001 68.8 µM 0.530603808371042 0.282856397457562 no 974 0.297846678025177 1399 3106768
SGTC_698 k064-0052 127 µM 0.527615544063698 0.28388139022158 no 975 0.298883101058469 1506 5088751
SGTC_2622 2-methoxyxanthone 59.94 µM 0.526685940983083 0.284200611875301 no 976 0.299205850141345 1560 71034 A hepatoprotective.
SGTC_2611 pyromycin 23.93 µM 0.5251289384502 0.28473566392746 no 977 0.299746780138259 1415 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2111 5486399 200 µM 0.524738456691807 0.284869925375087 no 978 0.299882509786066 1431 689674
SGTC_606 k015-0008 38.6 µM 0.524198696351981 0.285055563795461 no 979 0.300070173769221 1560 1970475
SGTC_1274 0865-0114 173 µM 0.523218638161132 0.285392780114294 no 980 0.300411056323376 1462 870624
SGTC_3348 9149464 3.537 µM 0.522517605988417 0.285634106248172 no 981 0.300654995689962 1428 1951442
SGTC_2514 salinomycin 42.74 µM 0.52124164061542 0.286073598744384 no 982 0.301099224857869 1558 23682228 A polyether potassium ionophore.
SGTC_998 3996-0085 177 µM 0.519477409118804 0.28668179796144 no 983 0.30171393129542 1557 715391
SGTC_861 0443-0273 110 µM 0.519172160259225 0.286787091302577 no 984 0.301820345569727 1477 6149169
SGTC_1397 3532-0190 20.1 µM 0.514422630092119 0.288427763449708 no 985 0.303478270378368 1469 5322280
SGTC_2654 protoveratrine a 100 µM 0.514214902674999 0.288499621434195 no 986 0.303550874834152 1450 5702278 A heart drug and vasodilator.
SGTC_413 propylparaben 100 µM 0.513379607862727 0.288788655435304 no 987 0.303842903616403 1422 7175 A pharmaceutical preservative.
SGTC_2034 5197015 53.07 µM 0.512054707975864 0.289247385081153 no 988 0.304306360867149 1549 780676
SGTC_447 ml7 120 µM 0.510910309838548 0.289643893785991 no 989 0.304706930806586 1550 4216 Selective myosin light chain kinase inhibitor.
SGTC_173 1273-0061 2.693 µM 0.510639780187876 0.289737663613755 no 990 0.304801657667091 1396 2847414 YPL266W DIM1
SGTC_2729 fluphenazine 10.66 µM 0.510576090882093 0.289759741399313 no 991 0.304823960593504 1400 3372 An atypical antipsychotic.
SGTC_929 2805-0021 398 µM 0.510128275724439 0.289914998017276 no 992 0.304980798422923 1505 3098024
SGTC_1709 st033179 39.1045 µM 0.508021767571716 0.290645843033242 no 993 0.305719038878921 1460 573381
SGTC_2156 5649887 115 µM 0.506420505394802 0.291201970783755 no 994 0.306280741297085 1565 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_148 3253-0744 288.01 µM 0.506316375578318 0.291238152877853 no 995 0.306317284504449 1429 6893655
SGTC_3186 9110464 49.47 µM 0.505138566184258 0.291647553558064 no 996 0.306730757759442 1514 17018021
SGTC_1500 4488-1866 171 µM 0.504917553681642 0.291724406287178 no 997 0.306808372244079 1567 2900003
SGTC_2360 9040895 200 µM 0.50452749028369 0.291860066146077 no 998 0.30694537462912 1426 4914414
SGTC_2265 7929201 200 µM 0.503598081620609 0.292183422863064 no 999 0.307271920467355 1418 1265108
SGTC_2166 5933061 31.504 µM 0.503205895617676 0.292319920882341 no 1000 0.307409760097014 1632 2877375
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.502595443443255 0.292532444137468 no 1001 0.307624366757313 1501 688664
SGTC_2669 eugenol 100 µM 0.501688641887305 0.292848271160494 no 1002 0.307943277659464 1508 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2180 6301957 200 µM 0.500849760543963 0.293140583336612 no 1003 0.308238431085374 1464 845462
SGTC_1232 0279-0259 161 µM 0.498692656525788 0.293892857050861 no 1004 0.308997959367882 1472 1560000
SGTC_2187 6125751 200 µM 0.497554758115221 0.294290049915737 no 1005 0.309398949232966 1491 874498
SGTC_248 streptozotocin 5.23457 mM 0.497198801717327 0.294414350333745 no 1006 0.309524433184949 1571 5300 DNA alkylating agent.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.494696999231432 0.295288665896955 no 1007 0.31040701002472 1385 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_507 nimesulide 162 µM 0.494666958767685 0.295299171522371 no 1008 0.310417614240116 1563 4495 A COX2 inhibitor.
SGTC_403 arphamenine a 50 µM 0.494083899393822 0.295503110668846 no 1009 0.310623464075141 1518 5487158 An arginine aminopeptidase inhibitor.
SGTC_326 k292-0812 17.5 µM 0.492537711329187 0.296044240789561 no 1010 0.311169634731191 1524 3579357
SGTC_2076 5212012 200 µM 0.492425394480898 0.296083566806314 no 1011 0.311209325407491 1459 604802
SGTC_2496 diffractaic acid 79.83 µM 0.492244687440125 0.296146843628004 no 1012 0.311273188507517 1614 94870 An apoptosis inducer which activates caspases.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.489921806793905 0.296960781121548 no 1013 0.312094615670976 1520 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1236 0330-0013 258 µM 0.489492772749015 0.297111226569162 no 1014 0.312246434989616 1481 4617066
SGTC_1611 st001856 99.4 µM 0.489309145619324 0.297175628064662 no 1015 0.312311423601241 1440 647478
SGTC_2947 9072639 7.68 µM 0.487482957269946 0.297816453743999 no 1016 0.31295805874401 1445 16488146
SGTC_981 1488-1094 54.9 µM 0.486501382455691 0.298161157257312 no 1017 0.313305862702941 1459 3449522
SGTC_1507 4075-3230 155 µM 0.486122650336294 0.298294206685918 no 1018 0.313440104270479 1452 659771
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.484610209488815 0.298825799795316 no 1019 0.313976435099144 1444 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1327 1436-0082 2.18 µM 0.48406265816578 0.299018359360195 no 1020 0.314170700790403 1499 15992205
SGTC_2130 NSC 7 2.4545 µM 0.483739190161187 0.299132141116205 no 1021 0.314285488178311 1592 21448
SGTC_1797 st048695 56.8 µM 0.483036792091189 0.299379281374999 no 1022 0.314534806323056 1576 592262 YIL048W NEO1
SGTC_2691 st077356 60.2 µM 0.48287691421013 0.299435547682864 no 1023 0.314591567244455 1609 2839272
SGTC_2917 7979103 53.79 µM 0.48243618290853 0.299590680408222 no 1024 0.314748061324955 1599 2980565
SGTC_2860 9025725 38.96 µM 0.482323564733868 0.299630326647951 no 1025 0.314788054923574 1463 40546248
SGTC_3184 9108758 49.47 µM 0.482159168160097 0.299688205285881 no 1026 0.314846440258253 1516 902885
SGTC_945 3381-0768 11.3 µM 0.481294030239381 0.299992875370529 no 1027 0.315153769654642 1518 1126236 YIL048W NEO1
SGTC_528 3492-0019 172 µM 0.481153593476905 0.300042345305109 no 1028 0.315203670132845 1527 2869262
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.480816720007265 0.300161026628902 no 1029 0.315323382928134 1509 97141
SGTC_1052 3253-3998 198 µM 0.480604889573526 0.300235665863524 no 1030 0.315398669827481 1469 5450317
SGTC_2721 ifenprodil 61.44 µM 0.480486041572079 0.30027754606923 no 1031 0.315440913089912 1578 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_639 0833-0042 114 µM 0.480209122469263 0.300375138339846 no 1032 0.315539350407948 1478 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1799 st045822 46.1415 µM 0.479123210080296 0.300757975527178 no 1033 0.315925489419247 1586 3674992
SGTC_480 am 92016 50 µM 0.479066127007375 0.30077810618966 no 1034 0.315945793121419 1458 2129 K+ channel blocker.
SGTC_1885 st057546 99.9 µM 0.478280341114123 0.3010552797055 no 1035 0.316225343289671 1584 702008
SGTC_1062 mesoridazine 14.2 µM 0.47721423761776 0.301431514745759 no 1036 0.316604786856789 1519 4078 A neuroleptic.
SGTC_2192 5915882 198.485 µM 0.474779131365682 0.302291672686426 no 1037 0.317472204458589 1497 2876149
SGTC_739 1486-1183 203 µM 0.473528640367362 0.302733813911705 no 1038 0.31791803637608 1589 4346692
SGTC_715 0868-0130 184 µM 0.472877168365094 0.302964272241976 no 1039 0.318150407410415 1663 2876258
SGTC_1301 naphtanilide LB 4.81 µM 0.471887724698455 0.303314438198591 no 1040 0.318503465173905 1623 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_999 SEC7.066 22.7 µM 0.470729870187931 0.303724434599572 no 1041 0.318916825405283 1571 740511 YDR170C SEC7
SGTC_2727 riluzole 51.77 µM 0.46802740706186 0.304682337936662 no 1042 0.319882495231885 1525 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2068 5226020 147 µM 0.467283513938512 0.304946250663076 no 1043 0.320148524945274 1494 1810509
SGTC_2598 perillyl alcohol 100 µM 0.466957335042923 0.30506200193971 no 1044 0.320265201627312 1580 10819 An apoptosis inducer.
SGTC_676 falcarinol 140 µM 0.465542749050077 0.305564222422211 no 1045 0.320771415388689 1646 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3220 9131269 49.47 µM 0.46430735236099 0.306003124822191 no 1046 0.321213778546523 1542 17722206
SGTC_197 4544-0043 41.561 µM 0.464253471998601 0.306022273376796 no 1047 0.321233077471496 1520 896523
SGTC_1819 st053448 58.6 µM 0.463857617124095 0.306162972584965 no 1048 0.321374879986897 1567 2857616
SGTC_2808 7946468 45.46 µM 0.460817916854078 0.30724432882543 no 1049 0.322464623079799 1574 2970879
SGTC_81 0411-0046 9.971 µM 0.459594920095763 0.307679877003789 no 1050 0.322903503036684 1474 12925265
SGTC_1228 0124-0032 52.5 µM 0.458228344912116 0.308166878876873 no 1051 0.32339419888638 1628 X1228
SGTC_1806 st050005 60.3 µM 0.458145783994667 0.308196311669926 no 1052 0.323423853869846 1502 5194765
SGTC_67 0335-0847 266 µM 0.455330117357868 0.309200828139967 no 1053 0.32443588109927 1774 4552207 YOR254C SEC63
SGTC_776 4476-4378 112 µM 0.452849396563788 0.310087033200882 no 1054 0.325328595713856 1544 2892008
SGTC_3004 9076122 71.4286 µM 0.452139465544293 0.310340850231476 no 1055 0.325584257047884 1619 44782551
SGTC_433 pimozide 108 µM 0.451384358694483 0.310610917848062 no 1056 0.325856277239501 1473 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_307 1501-1223 22.3 µM 0.449473913313163 0.311294653561925 no 1057 0.326544911167097 1555 2830329
SGTC_2237 6667747 47.222 µM 0.449052887833765 0.311445423482035 no 1058 0.326696752484691 1552 729940 YDL015C TSC13
SGTC_484 loperamide 105 µM 0.447817303336944 0.311888070862906 no 1059 0.327142527249304 1551 3955 An opioid-receptor agonist.
SGTC_2032 5185112 25.99 µM 0.447634870391546 0.311953450399403 no 1060 0.327208366411029 1564 5718189
SGTC_2811 7967822 32.47 µM 0.447132791115036 0.312133414004474 no 1061 0.327389592133711 1639 2232244
SGTC_231 b-estradiol 524 µM 0.445848841772495 0.312593832364476 no 1062 0.327853219165333 1508 450 A steroid.
SGTC_3296 9122258 64.045 µM 0.445242774011524 0.3128112672052 no 1063 0.328072159164893 1562 4730474
SGTC_2359 9039622 200 µM 0.445125423170637 0.312853375904785 no 1064 0.328114558603147 1623 6463596
SGTC_2970 9090938 41.86 µM 0.444897508481922 0.312935164921351 no 1065 0.328196911633082 1698 17217104
SGTC_19 0279-0214 38.434 µM 0.444391403192807 0.313116817790156 no 1066 0.328379813880147 1588 3566274 YBR002C RER2
SGTC_3169 9102970 49.47 µM 0.444229686956935 0.313174871045547 no 1067 0.328438265459293 1593 17027839
SGTC_139 0099-0334 718.624 µM 0.441253432994313 0.314244118992085 no 1068 0.329514767114954 1592 97690
SGTC_1636 st007707 68.9 µM 0.440526241654088 0.314505607092948 no 1069 0.329778005271106 1667 403051
SGTC_3309 9129340 25.759 µM 0.437907863200119 0.31544791054902 no 1070 0.33072653764562 1629 17158987
SGTC_1026 k007-1105 30.6 µM 0.43707163886134 0.315749104848507 no 1071 0.331029697344906 1561 7066794
SGTC_37 0566-0070 1.56 µM 0.436442669195373 0.315975730081004 no 1072 0.331257793227305 1673 1626686
SGTC_1193 1488-0126 41.5 µM 0.435322627479745 0.316379465636195 no 1073 0.331664131417071 1564 1384710
SGTC_1337 1486-1011 40.3 µM 0.434335028865877 0.316735641799673 no 1074 0.33202258519966 1555 X1337
SGTC_588 3970-1144 52.9 µM 0.432443692653192 0.317418223975575 no 1075 0.332709484035094 1629 1888707
SGTC_532 1548-0774 215 µM 0.431732714707889 0.317674976334657 no 1076 0.332967843722654 1689 5932993
SGTC_1657 st012939 43.4 µM 0.431673002959908 0.317696543771454 no 1077 0.332989545769313 1665 24207257
SGTC_2244 6635614 200 µM 0.431639833580529 0.31770852457049 no 1078 0.333001601317416 1567 836499
SGTC_2874 9043904 71.43 µM 0.431516743976757 0.317752986275058 no 1079 0.333046340251572 1567 4463428
SGTC_1845 st056753 3.01 µM 0.431084291061432 0.317909215213227 no 1080 0.333203541189492 1513 5375839
SGTC_2253 7938677 135.83 µM 0.431015268946381 0.317934153302234 no 1081 0.333228634127981 1686 2301972
SGTC_682 0kpi-0099 17 µM 0.429457274776283 0.318497285086238 no 1082 0.333795240166087 1561 1714895 YML126C ERG13
SGTC_795 0685-0265 78 µM 0.428375870893708 0.318888401673982 no 1083 0.33418874449981 1577 302754
SGTC_1737 st035557 69.7 µM 0.427728249530325 0.319122726667147 no 1084 0.334424490128501 1533 5716916
SGTC_549 1661-1316 519 µM 0.427506982648861 0.31920280292266 no 1085 0.334505050159541 1686 2857282
SGTC_2268 7933382 153.85 µM 0.427098634843735 0.319350605718475 no 1086 0.334653743622428 1559 935025 YOR257W CDC31
SGTC_2992 9074591 71.4286 µM 0.427047164613739 0.319369237571024 no 1087 0.334672487542145 1595 17741321
SGTC_628 1636-0253 16 µM 0.426698929023432 0.319495308326993 no 1088 0.334799315359533 1659 4456143
SGTC_2291 7917025 104.35 µM 0.426429889510297 0.319592722237443 no 1089 0.334897312776858 1524 2964612
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.424897574642452 0.320147780482115 no 1090 0.335455671392763 1545 6708561
SGTC_3270 9137563 49.47 µM 0.42406579191474 0.320449250123379 no 1091 0.33575891617926 1654 17015724
SGTC_2487 5918373 44.05 µM 0.422942722702663 0.320856481059812 no 1092 0.336168525602714 1648 2876279
SGTC_684 1140-0066 328 µM 0.422094604323687 0.321164156288408 no 1093 0.336477983069022 1582 6813534
SGTC_1912 st060209 90.8 µM 0.41884641099026 0.322343650396334 no 1094 0.337664191852796 1537 688787
SGTC_1520 flindersine 88 µM 0.418726942158901 0.322387066506738 no 1095 0.337707851568433 1758 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_343 4130-2827 29.8 µM 0.418589789103052 0.322436912219806 no 1096 0.3377579766519 1572 1118244
SGTC_1286 0929-0070 131 µM 0.417045983012111 0.322998199689167 no 1097 0.338322387040241 1672 1420408
SGTC_1588 farnesol 29.9 µM 0.416918974540323 0.323044394616529 no 1098 0.338368837114487 1571 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2485 5633444 17.78 µM 0.416814071435773 0.323082551541447 no 1099 0.338407204575376 1548 5724239
SGTC_1216 1165-0504 9.65 µM 0.416445428209947 0.323216654729475 no 1100 0.338542046153846 1692 6304004
SGTC_3083 9117465 49.47 µM 0.416177200530146 0.323314243694536 no 1101 0.338640170948208 1555 16420915
SGTC_518 1021-0119 62.6 µM 0.416055656759842 0.323358468826573 no 1102 0.338684638487661 1541 1097762
SGTC_2232 chlorophetanol 41.5365 µM 0.41604134312169 0.32336367717665 no 1103 0.338689875368647 1693 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1290 0986-0249 10.2 µM 0.415922478602396 0.323406930133162 no 1104 0.338733365121443 1605 53329
SGTC_313 3474-0040 5.03 µM 0.415255956028271 0.323649511567191 no 1105 0.338977269988805 1571 1043375 YIL048W NEO1
SGTC_2848 9016370 25.97 µM 0.414840331520433 0.323800816393816 no 1106 0.3391293963056 1739 7894410
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.413798796970984 0.324180106731365 no 1107 0.33951073254789 1627 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2248 tofa 1.1 µM 0.413744514993393 0.324199879331084 no 1108 0.339530611276431 1628 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3191 9110352 49.47 µM 0.412584745580746 0.32462245204925 no 1109 0.339955439707831 1635 17122424
SGTC_2869 9037858 32.47 µM 0.412432627517122 0.324677894439695 no 1110 0.340011176290484 1543 27187042
SGTC_210 3551-0445 56.827 µM 0.412264285315449 0.324739254561606 no 1111 0.34007286152945 1648 2865180 YOR207C RET1
SGTC_2768 sulfasalazine 50.2 µM 0.410103542449878 0.325527259323872 no 1112 0.340864997106597 1755 5384001 An antioxidant and salicylic acid derivative.
SGTC_1036 k216-0215 33.5 µM 0.40970637444417 0.325672188173836 no 1113 0.341010676723136 1589 622330
SGTC_2740 felodipine 17.08 µM 0.40963688413738 0.325697548289025 no 1114 0.341036167923705 1717 3333 L-type calcium channel blocker
SGTC_100 0086-0128 49.5915 µM 0.409409347506013 0.325780592208289 no 1115 0.341119640497156 1514 93297
SGTC_1647 st011722 22.4 µM 0.409011179506728 0.325925932163117 no 1116 0.341265728465971 1630 2854783
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.407027489188346 0.326650415990787 no 1117 0.341993899259857 1610 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1481 3346-2004 36 µM 0.406359098342813 0.326894673334659 no 1118 0.342239384011581 1619 2770522
SGTC_2008 4012253 172 µM 0.405415271095724 0.327239712734785 no 1119 0.342586143832259 1590 603940
SGTC_1841 st054148 70 µM 0.404940660899491 0.327413274055331 no 1120 0.342760564619018 1561 675442
SGTC_1816 st051957 91.6 µM 0.404848883800122 0.327446840545298 no 1121 0.342794296870011 1622 674121
SGTC_1815 st051655 58.2 µM 0.40468604337204 0.327506401119081 no 1122 0.342854151205496 1706 5984156
SGTC_502 l-744,832 89.3 µM 0.403302035361287 0.328012793490958 no 1123 0.343363022300171 1712 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_117 lucigenin 22.078 µM 0.402810033110875 0.328192887630914 no 1124 0.343543989837873 1552 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1190 1486-1332 13 µM 0.402320151284617 0.328372245288828 no 1125 0.343724213081141 1572 4150046
SGTC_425 3825-7017 13.1 µM 0.40133167440886 0.3287342711482 no 1126 0.344087973204854 1683 3397440
SGTC_2433 5607874 27.82 µM 0.400331907816262 0.329100595378283 no 1127 0.344456034767432 1571 2252428
SGTC_161 4065-0411 162.148 µM 0.399693836842084 0.329334476655628 no 1128 0.344691016041343 1680 1906281 YLR208W SEC13
SGTC_347 4534-1311 26.2 µM 0.397404994299289 0.330173987841234 no 1129 0.345534416591652 1604 2862016
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.396679128185494 0.330440402957563 no 1130 0.34580204669899 1595 390807
SGTC_2591 skatole 100 µM 0.395134015980384 0.331007792601233 no 1131 0.346371993022644 1632 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2263 7948595 193.29 µM 0.394522291703375 0.331232534814752 no 1132 0.346597736313236 1620 2971371
SGTC_1868 st057644 42.7 µM 0.392280455842875 0.332056685162201 no 1133 0.347425501364087 1611 688665
SGTC_1650 st011916 45.8 µM 0.390784817684458 0.332606968557669 no 1134 0.347978149071621 1737 242528
SGTC_1119 parthenolide 318.541 nM 0.389692866095299 0.3330089533834 no 1135 0.34838183617079 1728 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_851 0394-0702 453 µM 0.388888018493962 0.33330536831319 no 1136 0.348679492887175 1750 762646
SGTC_2100 5377183 190 µM 0.386720190586571 0.334104268766188 no 1137 0.349481683514523 1758 2844202
SGTC_1152 3909-8331 15.9 µM 0.386564076516728 0.334161829903645 no 1138 0.349539478519519 1632 16001939
SGTC_823 0417-1665 178 µM 0.385531505779087 0.33454264933602 no 1139 0.34992183440565 1672 3429856
SGTC_942 3253-1115 227 µM 0.383942168186995 0.335129141031205 no 1140 0.350510655716183 1751 46497897
SGTC_582 0987-0078 156 µM 0.382659965542616 0.335602588090029 no 1141 0.350985950993975 1659 1625765
SGTC_301 4119-0100 24.5 µM 0.381487262426884 0.336035831639901 no 1142 0.3514208605155 1660 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_55 0767-0285 6.563 µM 0.381293595255253 0.336107401039484 no 1143 0.351492702799145 1774 3116166
SGTC_1782 st039423 80.636 µM 0.380336626956116 0.336461134347283 no 1144 0.351847775168275 1597 2068169
SGTC_1302 1159-0335 255 µM 0.379978950141848 0.336593383024453 no 1145 0.351980520343597 1633 649284
SGTC_1707 st032323 6.317 µM 0.378291660679209 0.337217519691804 no 1146 0.352606969882975 1677 3132057 YMR211W DML1
SGTC_1753 st043925 64 µM 0.378140295912542 0.337273532199087 no 1147 0.352663187512477 1754 670181
SGTC_2471 5466956 24.79 µM 0.377448454993711 0.337529593721873 no 1148 0.352920181630546 1695 724419
SGTC_1394 3474-0001 65.7 µM 0.376998620715035 0.337696125046144 no 1149 0.353087314965397 1623 5017666 YIL048W NEO1
SGTC_2115 tiliquinol 12.7705 µM 0.375924185410381 0.338094015951899 no 1150 0.353486629868347 1678 71208 A bioactive hydroxyquinoline.
SGTC_919 tnp00227 403.569 nM 0.375242383763251 0.338346598423403 no 1151 0.353740105787207 1681 1269246 A methoxyflavone. YNL221C POP1
SGTC_640 3381-0960 37.1 µM 0.375142857413344 0.338383475369169 no 1152 0.353777112493503 1742 1745025
SGTC_11 0438-0307 1.3 µM 0.375093643553063 0.338401710880319 no 1153 0.353795412106513 1761 4011476
SGTC_1065 prochlorperazine maleate 2.48 µM 0.37505219587009 0.338417069036526 no 1154 0.353810824217065 1674 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1726 st035556 14.5795 µM 0.375011746337392 0.338432057594114 no 1155 0.353825865401503 1757 5919439
SGTC_341 1486-1430 230 µM 0.374783246613889 0.338516732878711 no 1156 0.353910837453193 1608 2054753 YPL210C SRP72
SGTC_3090 9117696 49.47 µM 0.373251867342976 0.339084427585799 no 1157 0.354480498146588 1766 7923821
SGTC_736 0958-0254 92.6 µM 0.371559760215598 0.339712130531929 no 1158 0.355110327031465 1719 6812352
SGTC_328 k915-0120 63.5 µM 0.371404275620402 0.339769831333857 no 1159 0.355168220737903 1769 6624543
SGTC_2892 9047358 58.44 µM 0.370488717077981 0.34010967397956 no 1160 0.355509190941168 1651 6466771
SGTC_2730 imipramine 71.33 µM 0.370090041732079 0.340257697371057 no 1161 0.355657700862317 1742 3696 A tricyclic antidepressant.
SGTC_1171 0368-0077 21.4 µM 0.369572173134258 0.340450012550589 no 1162 0.355850643990153 1647 3239779
SGTC_1030 k029-0042 36.7 µM 0.368840161123373 0.34072192259471 no 1163 0.356123433854937 1682 6080581
SGTC_3069 9117009 49.47 µM 0.368333547598851 0.340910155565869 no 1164 0.356312270391857 1689 41904981
SGTC_2138 5575593 77.673 µM 0.36696537504725 0.341418699839157 no 1165 0.356822422820408 1649 762213
SGTC_3237 9133362 49.47 µM 0.366745929416431 0.341500293735104 no 1166 0.356904271685378 1728 43845137
SGTC_323 4013-0906 34.3 µM 0.36621889015984 0.341696286817768 no 1167 0.357100873770759 1791 2910086
SGTC_2964 9083345 53.42 µM 0.363852623013193 0.342576769391733 no 1168 0.35798403224906 1632 17741579
SGTC_194 1486-1323 56.904 µM 0.363445115186956 0.342728488658694 no 1169 0.358136202710417 1646 5178754
SGTC_2086 5274770 176.623 µM 0.362961952646132 0.342908407810492 no 1170 0.358316653151478 1669 689278
SGTC_2815 7968870 71.43 µM 0.362343123290535 0.343138898351575 no 1171 0.358547818345001 1635 2977326 YHR190W ERG9
SGTC_1808 st050063 61.5 µM 0.361448200136126 0.34347232662487 no 1172 0.358882210712473 1761 4011993
SGTC_2070 5230947 200 µM 0.360864291265149 0.343689943662982 no 1173 0.359100449422828 1758 2835538
SGTC_3206 9114350 49.47 µM 0.357145641215506 0.345077060574529 no 1174 0.36049138889003 1669 17087243
SGTC_3078 9116413 49.47 µM 0.35620211192636 0.345429344586889 no 1175 0.360844605224489 1646 17177322
SGTC_2751 anetholtrithion 17.25 µM 0.354348837539934 0.346121688341521 no 1176 0.361538735946115 1806 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1686 st019653 115.5 µM 0.354299216536771 0.346140232773547 no 1177 0.361557327416677 1796 97252
SGTC_234 nsc-17383 10.7 µM 0.354113969912456 0.346209466665439 no 1178 0.361626736542292 1788 408974
SGTC_881 0833-0569 170 µM 0.351713874085906 0.347106940097706 no 1179 0.362526427282038 1630 5418700
SGTC_16 erodoxin 22.806 µM 0.35080483364296 0.347447084069959 no 1180 0.362867385333901 1714 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3120 9124077 49.47 µM 0.350485805353798 0.347566486945407 no 1181 0.362987070559054 1715 18774327 YGL155W CDC43
SGTC_1781 st038725 66.3 µM 0.350240836700428 0.347658181750841 no 1182 0.36307898098697 1682 4270275 YIL048W NEO1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.347248761214182 0.348778870555263 no 1183 0.364202220531727 1748 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_142 0335-0849 62.6745 µM 0.346802224809798 0.348946235293393 no 1184 0.364369952795954 1723 3889043 YPR107C YTH1
SGTC_1943 st076331 65.2 µM 0.346377987428393 0.349105269440767 no 1185 0.364529332952429 1775 24208415
SGTC_87 0100-0052 35.5 µM 0.345792042428241 0.349324966609588 no 1186 0.364749502950002 1760 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_576 1073-0113 22.7 µM 0.344503463817708 0.349808290299156 no 1187 0.36523384576802 1784 5439563
SGTC_3166 9102297 49.47 µM 0.343793917940509 0.350074532767786 no 1188 0.365500637265069 1672 25237072
SGTC_1773 st048542 73.5835 µM 0.343292574058026 0.350262696179578 no 1189 0.365689183401856 1629 3237138
SGTC_1685 st024049 53.0905 µM 0.339296383451407 0.351763849573244 no 1190 0.367193233413344 1729 1941139
SGTC_1916 st067606 49.2 µM 0.338320136522609 0.352130925522337 no 1191 0.36756097536297 1807 19590279
SGTC_1620 st003704 16.5 µM 0.335997871659678 0.353004667335809 no 1192 0.368436235720089 1833 2834414
SGTC_395 anisomycin 6.25 µM 0.335392189419075 0.353232680303066 no 1193 0.368664629528658 1721 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_847 0342-0274 5.54 µM 0.333984671248859 0.353762752952513 no 1194 0.369195562875908 1837 18097
SGTC_2885 9057732 51.95 µM 0.333669403063822 0.353881522160772 no 1195 0.369314520208054 1735 6471414
SGTC_647 0140-0236 81 µM 0.333438465485332 0.35396853099896 no 1196 0.369401665766161 1761 990837
SGTC_1605 st000082 49.1 µM 0.328089389003718 0.355985993169743 no 1197 0.371422038352324 1803 1114022
SGTC_2956 9076196 2.52 µM 0.327781739309145 0.356102149954871 no 1198 0.371538347577262 1774 16423868
SGTC_398 bronopol 33.3 µM 0.327306270349221 0.356281695159243 no 1199 0.371718125175549 1776 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2078 5212016 200 µM 0.32595935483774 0.356790486348211 no 1200 0.372227553596054 1860 1899708
SGTC_1164 k060-0068 93.7 µM 0.325355974359718 0.357018493290045 no 1201 0.372455835884165 1748 5963676
SGTC_321 4534-3890 65.3 µM 0.32420155019183 0.357454872306465 no 1202 0.3728927242635 1854 699746
SGTC_1971 st069429 63.5 µM 0.322723485720777 0.358013861360279 no 1203 0.373452332021437 1869 1246522 YGL099W LSG1
SGTC_2425 5628681 7.85 µM 0.321067224579666 0.358640604414672 no 1204 0.374079723724232 1844 5714958
SGTC_1484 3473-2379 286 µM 0.320081490711808 0.359013795257822 no 1205 0.374453278212064 1781 671917
SGTC_2393 9031399 185.94 µM 0.319561443802998 0.359210735055434 no 1206 0.374650403121918 1832 1526623 YDL150W RPC53
SGTC_1530 rhein 70.4 µM 0.318866065644646 0.359474130590505 no 1207 0.374914038906938 1774 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1224 0823-0416 294 µM 0.315848195493135 0.360618012684091 no 1208 0.376058867226036 1823 3598164
SGTC_3045 9092950 49.47 µM 0.31441994989081 0.361159805339191 no 1209 0.376601053036753 1878 44120432
SGTC_831 k061-1017 217 µM 0.314203314897505 0.361242008319288 no 1210 0.37668331258267 1869 1240153
SGTC_1165 k072-0275 30.3 µM 0.313721251775101 0.361424952010048 no 1211 0.376866379245672 1812 6153523 YGL055W OLE1
SGTC_2458 5808907 16.39 µM 0.312303857955826 0.361963038553267 no 1212 0.377404804178996 1881 2731747
SGTC_262 fenpropimorph 62.5 µM 0.308839639848164 0.363279309907959 no 1213 0.378721756951494 1735 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3312 9133330 71.43 µM 0.305783396213059 0.364441909065296 no 1214 0.379884785617379 1852 17617324
SGTC_679 0422-0091 41.4 µM 0.305603931509899 0.364510216578661 no 1215 0.379953113348692 1709 627384 YHR062C RPP1
SGTC_324 1315-0088 19.6 µM 0.304716058913482 0.364848220214526 no 1216 0.380291208843929 1811 6787421
SGTC_2133 5320837 200 µM 0.303646977143866 0.365255347654069 no 1217 0.380698428862445 1846 2841355
SGTC_2091 4-phenylthiadiazole 200 µM 0.303257154542386 0.365403837612696 no 1218 0.380846947677445 1772 270010
SGTC_2227 7312221 64.1025 µM 0.30247675130084 0.365701166890102 no 1219 0.381144326853207 1844 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_777 1315-0167 517 µM 0.302086265344875 0.365849970162463 no 1220 0.381293151152428 1725 4221767
SGTC_996 3970-0799 1.8 µM 0.301414018704015 0.366106191823207 no 1221 0.381549402854804 1908 6615648 YGL040C HEM2
SGTC_900 1112-0045 141 µM 0.299330833143423 0.366900560846663 no 1222 0.382343815496241 1872 56211 YIL048W NEO1
SGTC_3036 9090181 49.47 µM 0.297496188784898 0.367600627531713 no 1223 0.383043858634278 1794 25236586
SGTC_3104 9120930 49.47 µM 0.297468833880339 0.367611068998449 no 1224 0.383054299310818 1784 17014836
SGTC_1118 chelidonine 707.474 nM 0.297296463444671 0.367676865672632 no 1225 0.383120090708961 1931 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2403 6032726 181.2 µM 0.295838982108647 0.368233365725108 no 1226 0.383676525669559 1761 2881040
SGTC_2126 5251174 33.877 µM 0.295355415819414 0.368418063671891 no 1227 0.38386119392735 1948 790722
SGTC_2283 7944793 200 µM 0.29532733228591 0.368428791100734 no 1228 0.383871919508088 1720 2970533
SGTC_1518 st038567 90.8 µM 0.295052399319661 0.368533816200747 no 1229 0.383976925797166 1773 77966
SGTC_741 4582-0002 126 µM 0.293600067272264 0.369088773586734 no 1230 0.384531762184529 1756 2912688
SGTC_680 0417-1641 114 µM 0.29282347915664 0.36938563139095 no 1231 0.384828540363008 1764 2835990
SGTC_893 0958-0369 48.9 µM 0.29135141018045 0.36994855666333 no 1232 0.385391286155775 1929 6819948
SGTC_2941 9056145 11.23 µM 0.290400194951767 0.370312453648402 no 1233 0.385755047287699 1898 2119517
SGTC_2894 9048625 32.47 µM 0.288637990728945 0.370986909211695 no 1234 0.386429209935799 1920 4092861
SGTC_136 0097-0015 404.482 µM 0.286448883826986 0.371825307044899 no 1235 0.387267169294872 1928 4861337
SGTC_3284 9108171 64.8615 µM 0.282882676942753 0.37319241619372 no 1236 0.388633387119495 1819 8687505
SGTC_2963 9082507 9 µM 0.282252180836495 0.373434284265042 no 1237 0.388875074785292 1835 16459611
SGTC_1849 st056239 19.2 µM 0.281149420371301 0.373857440101253 no 1238 0.389297898600024 1701 5393181
SGTC_838 0109-0203 71.4 µM 0.279733302317616 0.374401061807116 no 1239 0.389841063172053 1816 759422
SGTC_3276 9139060 49.47 µM 0.278286827015624 0.374956594987993 no 1240 0.390396093705946 1847 4870619
SGTC_2612 dictamnine 15.46 µM 0.276879172830724 0.375497467743683 no 1241 0.390936442652891 1831 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2193 5925765 200 µM 0.276541504360146 0.375627248893279 no 1242 0.3910660930681 1897 877370
SGTC_1336 1486-0901 104 µM 0.2755313947535 0.376015563322352 no 1243 0.391454004673354 1856 5006114
SGTC_1986 st071812 45 µM 0.274331363110877 0.376477052286266 no 1244 0.391914992199347 1837 11838594
SGTC_721 1187-1332 279 µM 0.273531514885827 0.376784743249083 no 1245 0.392222335146708 1791 25730
SGTC_653 0203-0016 55.2 µM 0.27303443469778 0.376976002833754 no 1246 0.39241337289095 1854 295302
SGTC_909 3448-9333 149 µM 0.273026281523134 0.376979140150407 no 1247 0.392416506533422 1747 3344074
SGTC_1429 4049-0205 9.46 µM 0.272929368683878 0.377016432536388 no 1248 0.392453755158375 1858 22774478
SGTC_2997 9067075 71.4286 µM 0.272665009305596 0.377118164744966 no 1249 0.392555367171721 1879 27209819
SGTC_1300 1094-0077 113 µM 0.27083647413438 0.37782206475406 no 1250 0.393258402804573 1793 5532636
SGTC_3161 9100388 49.47 µM 0.270378499390522 0.3779984271334 no 1251 0.393434539661832 1867 25236368
SGTC_2643 anethole 100 µM 0.269045889033704 0.378511749156861 no 1252 0.393947184886623 1847 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2826 7992541 19.48 µM 0.268586270615509 0.378688844131101 no 1253 0.39412403932918 1889 2985066
SGTC_3094 9117742 49.47 µM 0.268362134412887 0.378775215002881 no 1254 0.394210291582466 1782 17149698
SGTC_3116 9124943 49.47 µM 0.268221004320493 0.378829602581897 no 1255 0.394264604027394 1728 41905195 YPL160W CDC60
SGTC_1618 st003135 44.5 µM 0.268082989911119 0.378882791784679 no 1256 0.394317719422598 1925 1270615
SGTC_64 000l-0018 272.079 µM 0.26745907291698 0.379123270993529 no 1257 0.394557860873003 1795 6811119
SGTC_26 0302-0163 425.158 µM 0.267045611736565 0.379282659028549 no 1258 0.394717021381829 1864 3100915
SGTC_1448 4255-0083 152 µM 0.265234900419593 0.379980924168715 no 1259 0.395414255369848 1940 5399660
SGTC_1439 4092-1168 46 µM 0.264699451167085 0.380187484715635 no 1260 0.395620500161522 1861 2886240
SGTC_2206 7254556 146.969 µM 0.264029888549262 0.380445830331302 no 1261 0.39587844397915 1934 4398905
SGTC_2887 9044784 58.44 µM 0.262057988703207 0.381206982230763 no 1262 0.396638367657515 1932 6465546
SGTC_1652 st011932 78 µM 0.260471187525414 0.381819820352051 no 1263 0.397250168743895 1931 1551076
SGTC_2967 9089538 49.85 µM 0.259175095023279 0.382320603872518 no 1264 0.397750073013162 2011 728216
SGTC_1136 pergolide 1.05886 µM 0.258718566691167 0.38249704397728 no 1265 0.397926196519584 1828 47811 A dopamine receptor agonist.
SGTC_3197 9113331 49.47 µM 0.258512338930845 0.382576755350981 no 1266 0.398005763698256 1955 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2582 agaric acid 100 µM 0.258052961149887 0.382754332419666 no 1267 0.398183016933676 1794 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2966 9084041 48.03 µM 0.257788982142373 0.382856387296126 no 1268 0.398284884075515 1662 17741380
SGTC_1608 st001473 40.5 µM 0.256565622287625 0.383329447040971 no 1269 0.398757058120952 1781 7292267
SGTC_2120 5538279 151.968 µM 0.256522514098849 0.383346119679365 no 1270 0.39877369907904 1872 2058197
SGTC_2943 9068529 45.32 µM 0.254056243117648 0.384300340086189 no 1271 0.399726053694907 1909 3270634
SGTC_525 k781-2675 26.7 µM 0.253323702332067 0.384583901515577 no 1272 0.400009040752598 1910 3651118 YDL195W SEC31
SGTC_867 0518-0118 155 µM 0.25298288406243 0.384715850952298 no 1273 0.400140719808722 2013 6848158
SGTC_2789 5281112 71.43 µM 0.251865072928357 0.385148710578612 no 1274 0.400572678599976 1789 765948
SGTC_1976 st070609 63.5 µM 0.250172872269465 0.385804268231633 no 1275 0.401226831566945 1900 682556
SGTC_1134 3477-0009 42.5 µM 0.249955927027606 0.385888336340804 no 1276 0.401310716024193 2001 3973534
SGTC_2594 a-mangostin 100 µM 0.249915406810496 0.385904038860461 no 1277 0.401326384152195 1968 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1662 st014054 52 µM 0.249507275621108 0.386062209539447 no 1278 0.401484206851818 1950 2838777
SGTC_1451 4152-0210 104 µM 0.248317107554609 0.386523565592576 no 1279 0.401944531768317 1973 659563
SGTC_2231 micatex 6.853 µM 0.245800461728155 0.387499644318489 no 1280 0.402918349809478 1913 20737 An antifungal of unknown mechanism.
SGTC_202 3594-0513 34.79 µM 0.245250760796645 0.387712940204829 no 1281 0.403131137393822 1975 708429
SGTC_738 1315-0003 72.4 µM 0.244981001806547 0.387817624945191 no 1282 0.403235570788574 1961 6251474
SGTC_287 k060-0039 29.6 µM 0.243667451880273 0.388327487586398 no 1283 0.403744191642011 1978 5861974
SGTC_2461 5755302 26.15 µM 0.242666609192639 0.388716100220689 no 1284 0.404131838178857 1986 2788904
SGTC_1510 1123-0200 71.5 µM 0.242160766155859 0.388912554104238 no 1285 0.404327797222413 1964 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_858 0438-0351 2.77 µM 0.241064032700777 0.389338589163839 no 1286 0.404752744283217 1853 2799119
SGTC_389 tpck 16.7 µM 0.238643664679007 0.390279271023098 no 1287 0.405690951825613 1871 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_208 k072-0098 12.366 µM 0.238594749286849 0.390298288752607 no 1288 0.405709918510606 1964 5948901
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.237006857711462 0.390915784663784 no 1289 0.406325735065458 1828 688664
SGTC_726 3448-4391 34.2 µM 0.236745329517635 0.39101751362443 no 1290 0.406427183274826 1963 1356692
SGTC_2173 5763948 167 µM 0.236224564733784 0.391220102362938 no 1291 0.406629209468428 1986 2867177
SGTC_3025 9087895 49.47 µM 0.23488672493947 0.391740686103507 no 1292 0.407148326661795 2005 17173641
SGTC_903 1134-0042 114 µM 0.234776880164724 0.391783437817916 no 1293 0.407190956596926 1865 701009
SGTC_141 0443-0274 32.331 µM 0.234238730774485 0.391992905062945 no 1294 0.407399824226214 2027 1627241
SGTC_1428 4049-0204 61.7 µM 0.231742304790825 0.392965013098343 no 1295 0.408369085600853 1990 X1428
SGTC_2329 6138490 200 µM 0.231687659942187 0.392986299288932 no 1296 0.408390308282513 1877 720019
SGTC_2984 9022109 38.96 µM 0.23135682073965 0.393115180231753 no 1297 0.4085188036243 2063 6459207
SGTC_2456 5770359 74.46 µM 0.229480585997868 0.393846303063662 no 1298 0.409247704091311 1990 3118787
SGTC_3023 9089636 49.47 µM 0.228893474191329 0.3940751632048 no 1299 0.409475856389073 2057 17249241
SGTC_2235 salicylic acid 500 µM 0.228838095616316 0.394096752035947 no 1300 0.409497378148275 2010 338 A COX inhibitor and kinase inhibitor.
SGTC_2567 aureobasidin a 60 nM 0.228662057000673 0.39416538124175 no 1301 0.409565793794531 1918 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_982 1491-0518 27.5 µM 0.226118315664225 0.395157432575481 no 1302 0.410554699818727 1900 3091256
SGTC_508 roscovitine 141 µM 0.225834202170844 0.395268278299271 no 1303 0.410665187342961 1945 160355 A CDKinase inhibitor.
SGTC_894 0960-0238 55.9 µM 0.222095285608797 0.39672778777958 no 1304 0.412119853880372 2023 6741907 YDL195W SEC31
SGTC_918 glabranin 770.725 nM 0.22182678688436 0.396832653903302 no 1305 0.412224362993688 1935 124049 Also referred to as licorice root.
SGTC_3065 9113888 49.47 µM 0.218998245879823 0.397937834092702 no 1306 0.413325707094332 1980 16648368
SGTC_1534 6-azauridine 81.6 µM 0.218195876823084 0.398251488904843 no 1307 0.41363824875554 1926 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_786 4544-0069 423 µM 0.218170767838744 0.398261305342647 no 1308 0.41364803018084 1974 748821 YLR208W SEC13
SGTC_2926 9010726 65.15 µM 0.217534257210553 0.398510172698798 no 1309 0.413896006364477 1857 2994293
SGTC_1681 tripelennamine 100 µM 0.216898234233949 0.398758890622441 no 1310 0.414143826863901 2022 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_707 0865-0008 204 µM 0.216791532055578 0.398800620730902 no 1311 0.414185405737356 1958 723043
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.216508448310511 0.398911337434252 no 1312 0.414295720264939 1804 641818 YHR062C RPP1
SGTC_2309 7664088 163.95 µM 0.216270067236925 0.399004576813493 no 1313 0.414388619912478 2074 704922
SGTC_2868 9035608 32.47 µM 0.215476880348615 0.399314862088169 no 1314 0.414697767758898 1895 6462614
SGTC_2429 5902844 64.44 µM 0.215475472057848 0.399315413051395 no 1315 0.414698316693055 2036 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1560 lithocholic acid 53.1 µM 0.215084884282104 0.39946822978685 no 1316 0.414850569357216 2032 9903 A bile acid which acts as a detergent.
SGTC_1567 st069303 68.4 µM 0.213153212145046 0.400224218928818 no 1317 0.41560373044589 1906 5581319
SGTC_1856 st057054 55.7 µM 0.2112420630981 0.400972544168206 no 1318 0.416349194814797 2050 1266018
SGTC_1412 3909-8563 178 µM 0.210962202166444 0.401082156463938 no 1319 0.416458382929274 2047 23767530
SGTC_460 trequinsin 123 µM 0.209765232745985 0.401551057675837 no 1320 0.416925454789138 2037 5537 A vasodilator.
SGTC_2902 5787006 60.46 µM 0.208310940111214 0.402120953507845 no 1321 0.417493095019877 1901 591003
SGTC_1728 st035614 33.7865 µM 0.207841776659493 0.402304849756 no 1322 0.417676255881397 1926 15945546
SGTC_2417 cerulenin 830 nM 0.205893886120474 0.403068587978509 no 1323 0.418436900652616 2065 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_667 1498-1044 59 µM 0.204665231749307 0.403550515105915 no 1324 0.418916843198283 1944 6739982
SGTC_1701 st028638 40.4 µM 0.204556119143816 0.403593320503704 no 1325 0.418959471105123 2022 3490878
SGTC_71 0417-1750 47.813 µM 0.202523658833377 0.404390874995877 no 1326 0.41975368226663 2085 6811472
SGTC_2363 9053361 176 µM 0.20000687981904 0.405379030754244 no 1327 0.420737600259776 2056 6469797 YMR079W SEC14
SGTC_2107 5363541 170.161 µM 0.198802904307964 0.405851957995045 no 1328 0.421208462015813 2048 244052
SGTC_2715 st079500 56.4 µM 0.197331188678978 0.406430241434142 no 1329 0.421784187062041 1923 28246688
SGTC_2980 9014342 25.29 µM 0.196875372142864 0.406609387576145 no 1330 0.421962533332883 1958 2996599
SGTC_1777 st045864 34.765 µM 0.196621126569831 0.406709320294633 no 1331 0.422062018359871 2056 4691462
SGTC_3003 9075612 71.4286 µM 0.196388984759662 0.406800570305282 no 1332 0.42215285863826 1963 6501993
SGTC_571 k831-0106 44.2 µM 0.195466899128525 0.4071630724861 no 1333 0.42251372425931 2079 4783639
SGTC_1326 1431-2094 10.8 µM 0.195322861466769 0.407219705617259 no 1334 0.422570100437214 1888 616278
SGTC_27 0485-0001 32.618 µM 0.195071283569648 0.407318626371129 no 1335 0.422668571545414 2069 2054479
SGTC_1207 2099-0101 141 µM 0.194537548833083 0.407528511124325 no 1336 0.422877498782331 2069 5837381
SGTC_3321 9137793 26.8275 µM 0.193962490209822 0.40775467570699 no 1337 0.423102626282155 2055 4904192
SGTC_3033 9090887 49.47 µM 0.193406543587326 0.40797335296872 no 1338 0.42332029557274 1924 19325384
SGTC_2855 9016525 58.44 µM 0.19312279383408 0.408084974772792 no 1339 0.423431400889004 2009 43811474
SGTC_2735 sertaconazole 140 nM 0.192576927660522 0.408299729207212 no 1340 0.423645157869115 2091 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3295 9122362 53.5725 µM 0.19137090443179 0.408774299914915 no 1341 0.424117506838478 1912 4730473
SGTC_1602 st001878 87.6 µM 0.189875916610532 0.40936276396321 no 1342 0.424703182451091 2029 595405 YLR310C CDC25
SGTC_2089 5281248 129.67 µM 0.187852804930938 0.410159435644738 no 1343 0.425496020099299 1944 2737878
SGTC_2105 5350118 200 µM 0.187849805889046 0.410160616899563 no 1344 0.425497195618918 1935 2133313
SGTC_513 4245-1575 41.7 µM 0.185852277525971 0.410947578762322 no 1345 0.426280303548253 2041 719745
SGTC_1826 st055655 41.6 µM 0.185436625784891 0.411111377338179 no 1346 0.426443291662173 1955 676168
SGTC_2905 7799065 20.05 µM 0.185015342777562 0.411277410878461 no 1347 0.42660850076498 2073 1296806
SGTC_1420 4'-methoxyflavone 42 µM 0.184804700087232 0.411360434077868 no 1348 0.426691110612622 2085 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_947 3447-0010 211 µM 0.184642754745252 0.41142426629056 no 1349 0.426754624521612 2060 748350
SGTC_1817 st052116 64.4 µM 0.184614133715329 0.411435547770712 no 1350 0.426765849700781 2058 4361398
SGTC_527 4476-4215 268 µM 0.184388484334617 0.411524493989424 no 1351 0.426854351552931 1956 4418754
SGTC_2463 5473429 200 µM 0.183895255371553 0.411718930253033 no 1352 0.427047813500015 1960 5399405
SGTC_2418 pentamidine 31.67 µM 0.183411450191623 0.411909672620623 no 1353 0.427237596152913 2109 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2267 7931562 200 µM 0.182168870470473 0.412399660543454 no 1354 0.427725100984365 1828 934880
SGTC_1594 piperine 70.1 µM 0.17883851864943 0.413713593589553 no 1355 0.429032249655675 1948 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2378 9074213 121.43 µM 0.177499038901372 0.414242335717416 no 1356 0.42955821004655 2083 657714
SGTC_2241 6772625 37.8075 µM 0.175264773943377 0.415124628096532 no 1357 0.430435794814137 2147 2285411
SGTC_483 fpl-64176 144 µM 0.17510613415509 0.41518728994403 no 1358 0.430498119191786 2095 3423
SGTC_936 3005-4620 401 µM 0.174926172965989 0.415258376239858 no 1359 0.43056882214549 2113 777207
SGTC_119 0121-0043 24.815 µM 0.173413662126955 0.415855941103969 no 1360 0.431163143486049 2118 1092378
SGTC_771 0250-0039 27.3 µM 0.172327699737444 0.416285104726198 no 1361 0.43158995442563 1982 3005115
SGTC_2399 5884133 200 µM 0.17126762855786 0.416704132641716 no 1362 0.432006666509949 1956 722445
SGTC_2351 9026858 72.31 µM 0.17048782742755 0.417012435081139 no 1363 0.432313253265984 2000 1409300
SGTC_2778 tioconazole 65.09 nM 0.169387967623227 0.417447362748035 no 1364 0.432745743598426 2048 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2318 6029776 164 µM 0.168843197260435 0.417662823739952 no 1365 0.432959989787035 2045 818325
SGTC_1270 0831-1170 17.3 µM 0.168800709490889 0.417679629029237 no 1366 0.432976700120525 2084 6764716
SGTC_457 grayanotoxin iii 135 µM 0.168608469282679 0.417755668137964 no 1367 0.433052309211017 2032 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1992 st073643 23.3 µM 0.168289154503454 0.417881977392514 no 1368 0.433177902817197 2050 3161292
SGTC_1392 3455-1037 33.9 µM 0.16819371452577 0.417919731603979 no 1369 0.433215442794264 2073 981132
SGTC_3086 9117350 49.47 µM 0.167890656706541 0.418039620435849 no 1370 0.433334650331544 2094 2679265
SGTC_2211 7117706 200 µM 0.167736249029222 0.418100706613856 no 1371 0.433395388794152 2109 822771
SGTC_2673 kobusone 100 µM 0.166947402487881 0.41841281788211 no 1372 0.433705717352709 2061 6710676 An epoxy ketone and protein crosslinker.
SGTC_2499 avocadenofuran 51.48 µM 0.166913858603035 0.41842609083608 no 1373 0.433718914268182 1913 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2911 7942208 15.64 µM 0.166069553668854 0.418760203757958 no 1374 0.434051107033742 1970 1243384
SGTC_2692 st077426 47.7 µM 0.165493901172875 0.418988037699594 no 1375 0.434277624903238 2094 25238571
SGTC_879 0831-1030 162 µM 0.164739909140469 0.419286496634306 no 1376 0.434574351584035 1961 1549252
SGTC_1716 st033144 30.6155 µM 0.164610560720975 0.419337702366829 no 1377 0.434625259182231 2116 674617
SGTC_2512 diallyl trisulfide 49.23 µM 0.163900612882172 0.419618776870711 no 1378 0.434904692307484 2136 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2435 5706476 10.6 µM 0.163357324863856 0.419833897017375 no 1379 0.435118550647841 2131 5725375
SGTC_1049 3226-0134 66 µM 0.163281858267919 0.419863780642517 no 1380 0.435148258605439 2104 5702385
SGTC_2795 7780010 54.55 µM 0.163217032730024 0.41988945093933 no 1381 0.435173777927801 2017 953673
SGTC_1057 3448-5381 134 µM 0.163134152785006 0.4199222711062 no 1382 0.435206404969504 2096 5497911
SGTC_596 1155-0152 116 µM 0.162406097733023 0.420210602256799 no 1383 0.43549303464539 2005 280313
SGTC_602 3130-1533 38.1 µM 0.162375444618902 0.420222742729434 no 1384 0.435505103285301 2112 720941
SGTC_2830 7992007 71.43 µM 0.16236715386913 0.4202260263769 no 1385 0.435508367501445 1929 1952075
SGTC_2853 9015042 58.44 µM 0.1622931955462 0.420255318672897 no 1386 0.435537486407466 2045 6457456
SGTC_544 k015-0020 52.4 µM 0.16217226476942 0.420303216060751 no 1387 0.435585100083233 2004 3008304
SGTC_794 k038-0031 316 µM 0.160888504608219 0.420811751133134 no 1388 0.436090608173992 2094 6624242
SGTC_1407 3909-7909 12.3 µM 0.160415586909306 0.420999121069557 no 1389 0.436276856020179 2018 4411780
SGTC_2922 7999257 32.47 µM 0.160243364172019 0.421067360145117 no 1390 0.436344685527975 2102 2988377
SGTC_2770 toltrazuril 17.5 µM 0.15930734649243 0.42143827582579 no 1391 0.436713366506733 2123 68591 Kills coccidiodes.
SGTC_2218 6965428 192.983 µM 0.15839673805817 0.421799189500743 no 1392 0.437072091992585 2092 675684
SGTC_1573 oleylamine 1.06 µM 0.158191409875929 0.421880579065194 no 1393 0.437152986226412 2006 5356789 An amine of the fatty acid oleic acid.
SGTC_2386 9075165 157.42 µM 0.157667847806169 0.422088127720272 no 1394 0.437359268638418 2043 16452277
SGTC_504 lovastatin 124 µM 0.157582652534821 0.422121902582073 no 1395 0.437392837017947 1954 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1659 st012954 42.1 µM 0.1574221236333 0.422185544307167 no 1396 0.437456089347814 2076 24207262
SGTC_1460 k062-0059 9.15 µM 0.152558590772071 0.424114648979265 no 1397 0.439373191211124 2093 1373085
SGTC_1953 st076800 12.1 µM 0.152452399693835 0.424156789795459 no 1398 0.439415065524771 1913 297591
SGTC_1419 3993-2473 62.6 µM 0.151397347113145 0.424575523383275 no 1399 0.439831141019742 2050 704026
SGTC_392 N-ethylmaleimide 8.33 µM 0.151114297797758 0.424687875657847 no 1400 0.439942777004651 2012 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3073 9114972 49.47 µM 0.150862150069405 0.424787967154191 no 1401 0.440042229279735 2157 41905075
SGTC_378 3970-0959 8.33 µM 0.14926765505441 0.425421023190227 no 1402 0.440671218416449 2063 6615653
SGTC_1861 st057647 17.4 µM 0.147519237369233 0.426115411549357 no 1403 0.44136109830839 2126 688668
SGTC_2383 9036125 200 µM 0.146891593771377 0.426364737743629 no 1404 0.441608793573176 2051 79580
SGTC_2421 5690543 90.72 µM 0.146538993451758 0.42650481820328 no 1405 0.441747954909004 2044 3397993
SGTC_2439 5492030 7.2 µM 0.144523306330761 0.427305784457515 no 1406 0.44254362692643 2153 5722370
SGTC_2731 amoxapine 43.43 µM 0.143566565975799 0.427686065997486 no 1407 0.442921371788948 2197 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1984 st072354 53.1 µM 0.143522461204543 0.427703598217986 no 1408 0.442938786702179 2064 5762938
SGTC_1340 1486-1359 257 µM 0.141822618069245 0.428379416434851 no 1409 0.443610059007299 2049 4309068
SGTC_601 0986-0029 62.9 µM 0.141637880550627 0.428452876481446 no 1410 0.443683022099933 2073 24747981
SGTC_2446 5162541 200 µM 0.138990268572725 0.429505958675931 no 1411 0.444728919480211 2049 1549321
SGTC_349 k015-0014 24 µM 0.137598869591057 0.430059586390856 no 1412 0.445278724483214 2028 2196908
SGTC_1495 4469-0029 237 µM 0.136726293532152 0.430406848413362 no 1413 0.445623572735762 2136 793680
SGTC_1436 4092-1007 8.32 µM 0.134978937416943 0.431102411156567 no 1414 0.446314263710083 2142 2881121
SGTC_263 alizarin 107.927 µM 0.133850705257224 0.431551635511943 no 1415 0.446760315456592 2156 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_780 0109-0199 192 µM 0.133505953936027 0.43168892165913 no 1416 0.446896627931928 2182 610414
SGTC_3175 9106517 49.47 µM 0.131123574608557 0.432637852401564 no 1417 0.447838776163667 2062 41468073
SGTC_2261 9010538 184.68 µM 0.127975049698461 0.433892543634995 no 1418 0.449084359058769 2023 6457250
SGTC_1424 4048-1941 275 µM 0.127794181124924 0.433964640354403 no 1419 0.449155927547994 2169 X1424
SGTC_9 0092-0002 10.449 µM 0.126050860936999 0.434659664222593 no 1420 0.449845832203079 2178 759368
SGTC_1395 3486-0190 4.35 µM 0.125327809360566 0.43494798855179 no 1421 0.450132018531649 2182 6748079
SGTC_2702 st077768 96.8 µM 0.125298744449741 0.434959579211273 no 1422 0.450143523067634 2064 6484119
SGTC_146 3448-8650 53.125 µM 0.124432515373039 0.43530504425442 no 1423 0.450486414927324 2074 2891488 YIL048W NEO1
SGTC_1859 st055998 20 µM 0.124110836868704 0.435433347016553 no 1424 0.450613758961043 2207 676301
SGTC_2556 citropten 84.59 µM 0.123949021746797 0.435497890197617 no 1425 0.450677819221806 2169 2775 A potential DNA crosslinker.
SGTC_1198 1612-1005 86.7 µM 0.123881251832334 0.435524922087056 no 1426 0.450704648730247 2169 6998509
SGTC_3233 9132340 49.47 µM 0.122785275837058 0.435962123922474 no 1427 0.451138567103206 2067 17682950
SGTC_1314 1222-0010 41.1 µM 0.122554018648831 0.436054386021682 no 1428 0.451230133833889 2087 3526027
SGTC_3241 9133421 49.47 µM 0.122529838844636 0.436064032969305 no 1429 0.45123970802404 2190 17018221
SGTC_1276 0871-0068 94.2 µM 0.120904608624069 0.436712533356003 no 1430 0.451883295899308 2165 3414906
SGTC_17 0960-0276 49.807 µM 0.119305824738707 0.437350647116875 no 1431 0.452516534493937 2199 6821114
SGTC_3242 9133940 49.47 µM 0.11895911000359 0.437489051013532 no 1432 0.4526538755843 2165 17248444
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.118654523174925 0.437610644324131 no 1433 0.452774533588389 2187 165506
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.118563086997905 0.437647147471417 no 1434 0.45281075566022 2198 1377
SGTC_2839 9003951 25.97 µM 0.118219515311994 0.437784312888228 no 1435 0.452946863701884 2258 2990634
SGTC_2940 9060638 45.86 µM 0.118196784722872 0.437793387970701 no 1436 0.452955868760062 2069 4027022
SGTC_2722 naftopidil 47.16 µM 0.118018728186613 0.43786447735012 no 1437 0.453026409320075 2167 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3289 9119912 71.43 µM 0.117018216783157 0.438263970485142 no 1438 0.453422808875803 2147 17014829
SGTC_3315 9136395 68.55 µM 0.116193513487612 0.438593312712714 no 1439 0.453749588710202 2207 16876844
SGTC_474 dl-dihydrosphingosine 5 µM 0.115403655137063 0.438908779611746 no 1440 0.454062590970329 2176 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.114977354359202 0.439079058918001 no 1441 0.454231535795202 2154 5106787 A p450 inhibitor.
SGTC_1056 3448-1962 115 µM 0.114814561052811 0.439144087183488 no 1442 0.454296053666664 2111 715507
SGTC_1473 k844-0725 134 µM 0.114476344695957 0.439279193951696 no 1443 0.454430098654255 2206 54682906
SGTC_846 0335-0850 148 µM 0.113736521534656 0.439574754611492 no 1444 0.4547233301813 2208 6819598
SGTC_1311 1190-0148 100 µM 0.112591940772505 0.440032082958711 no 1445 0.455177037375669 2197 1961333
SGTC_2711 st079103 59.1 µM 0.112487618844763 0.440073769785287 no 1446 0.45521839308323 2172 54693780
SGTC_353 1988-1175 58.3 µM 0.112143421419557 0.440211315073909 no 1447 0.455354844615568 2078 2788357
SGTC_260 nsc-65238 3.989 µM 0.111486814854395 0.440473722680597 no 1448 0.455615160320065 2189 3246252
SGTC_1738 st035555 74 µM 0.111125226327904 0.44061823983799 no 1449 0.455758522455464 2136 5331140
SGTC_2023 5144124 124 µM 0.110449895487332 0.440888172482219 no 1450 0.456026292136308 2130 2830192
SGTC_2315 7733312 200 µM 0.109373732180558 0.441318376297142 no 1451 0.456453033710357 2126 726316
SGTC_2665 lovastatin 100 µM 0.10859764761708 0.44162866453916 no 1452 0.45676081332485 2131 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1218 1348-1416 30.7 µM 0.107963970625308 0.441882043043287 no 1453 0.457012136190875 2180 6787668
SGTC_1665 st014639 11.4 µM 0.107800861875519 0.441947266639805 no 1454 0.457076829599012 2214 981133 YIL048W NEO1
SGTC_670 4204-0025 119 µM 0.107234014162995 0.442173948783637 no 1455 0.457301665798962 2162 719039
SGTC_1256 0570-0116 285 µM 0.107178325032364 0.442196219864549 no 1456 0.457323755243504 2115 410638
SGTC_1637 st007924 17.4 µM 0.10672259351707 0.442378481920173 no 1457 0.457504528968624 2198 683336
SGTC_2786 7743617 45.45 µM 0.106567271881249 0.442440602951195 no 1458 0.457566141971364 2088 583674
SGTC_2829 7992743 58.44 µM 0.105950220516103 0.442687407177082 no 1459 0.457810924030672 2255 16462845
SGTC_1923 st058458 19.1 µM 0.105771644165123 0.442758837148567 no 1460 0.457881767617421 2250 3534982
SGTC_1772 st048439 82.2 µM 0.103764507393479 0.443561812908364 no 1461 0.458678116687294 2079 2927068 YDL195W SEC31
SGTC_1277 0873-0036 22 µM 0.102952770257124 0.443886622732246 no 1462 0.459000227781652 2190 5965735
SGTC_1476 4112-3294 3.34 µM 0.102691596342112 0.443991137315525 no 1463 0.459103871765034 2176 704369
SGTC_3173 9105693 49.47 µM 0.102036783939451 0.444253192253945 no 1464 0.459363739040544 2187 17096658
SGTC_1767 st044992 70.3 µM 0.101831206579776 0.444335469036474 no 1465 0.459445327563706 2149 9600693
SGTC_2974 9094440 9.66 µM 0.10096749195136 0.444681173645004 no 1466 0.459788132965712 2160 25236134
SGTC_797 k781-0471 270 µM 0.100961286799542 0.444683657429908 no 1467 0.459790595877856 2169 23738129
SGTC_2521 angolensin 13.4 µM 0.0990603983217795 0.44544464279299 no 1468 0.460545157470923 2148 821428 A flavenoid.
SGTC_985 1493-0307 8.71 µM 0.098713742449211 0.445583441785143 no 1469 0.460682778632148 2238 3278274
SGTC_1238 0333-0287 48.8 µM 0.0986174166572161 0.445622011256089 no 1470 0.460721020469339 2175 7226
SGTC_89 0302-0250 142.109 µM 0.0972363361821117 0.446175061232612 no 1471 0.46126935632598 2256 4203518 YLR208W SEC13
SGTC_1374 2889-5571 141 µM 0.0969716994077853 0.446281046309408 no 1472 0.461374434552959 2138 2853281
SGTC_864 0469-0573 172 µM 0.0968776826592102 0.446318700248297 no 1473 0.461411766043142 2056 689425
SGTC_3054 9094397 49.47 µM 0.0951283458434975 0.447019401880082 no 1474 0.462106441719366 2194 2598354
SGTC_2031 5180455 200 µM 0.0946013645696161 0.447230518187966 no 1475 0.462315732964525 2231 29949
SGTC_2836 9010338 19.48 µM 0.0942603291243501 0.447367149885202 no 1476 0.462451181165488 2112 2994051
SGTC_969 1313-0238 134 µM 0.0942488598542355 0.447371745017231 no 1477 0.462455736462787 2157 5212874
SGTC_2587 piperic acid 92.2 µM 0.0937313180528836 0.447579104081274 no 1478 0.462661295789094 2146 5370536
SGTC_1393 3470-5649 58.2 µM 0.0934594978825461 0.447688017695377 no 1479 0.462769262410978 2166 4108395
SGTC_3157 9099274 49.47 µM 0.0931476020723908 0.447812993780193 no 1480 0.462893150404182 2244 17217662
SGTC_286 k060-0067 22.9 µM 0.0931456774795325 0.447813764977152 no 1481 0.462893914882023 2177 5985051
SGTC_132 0417-1715 25.805 µM 0.0922813614175493 0.448160121975324 no 1482 0.463237248304427 2256 6769098
SGTC_401 neomycin 50 µM 0.0918073041139082 0.448350107552099 no 1483 0.463425570365139 2143 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2252 omeprazole 400 µM 0.0901930362227638 0.44899713822376 no 1484 0.464066909031677 2194 4594 A proton pump inhibitor.
SGTC_269 exalamide 29 µM 0.0901015345891511 0.449033817977056 no 1485 0.464103264878018 2126 3316 A derivative of salicylamide.
SGTC_2449 5812982 45.77 µM 0.089741170241333 0.449178279470951 no 1486 0.464246449395929 2248 776185
SGTC_3278 9139605 49.47 µM 0.0889061597569713 0.449513041168701 no 1487 0.464578244081381 2204 7958859
SGTC_446 go6976 132 µM 0.088765997614771 0.449569236706527 no 1488 0.464633940478022 2244 3501 A protein kinase C inhibitor.
SGTC_2760 etidronate 98.04 µM 0.0885357456717739 0.44966155435539 no 1489 0.464725437469327 2210 3305 A chelator and antioxidant.
SGTC_2895 9054447 58.44 µM 0.0878704620974981 0.449928309699621 no 1490 0.464989816800399 2173 2697450
SGTC_3051 9093778 49.47 µM 0.0872262500980897 0.450186637646659 no 1491 0.465245837156124 2263 17217378
SGTC_1942 st076330 65.2 µM 0.0868721651081072 0.450328634138533 no 1492 0.465386562439967 2198 24208414
SGTC_2127 5253358 187.912 µM 0.0867017312529302 0.450396984430988 no 1493 0.465454300130499 2192 20612
SGTC_2400 5203494 178.7 µM 0.0859308218784423 0.450706166009229 no 1494 0.465760704903754 2255 6777674
SGTC_2883 9059145 45.46 µM 0.0842477154995958 0.45138129780248 no 1495 0.466429740761595 2229 16476510
SGTC_1381 2324-0066 62.1 µM 0.0836871569131083 0.451606181769109 no 1496 0.466652584310556 2184 10885928
SGTC_3351 9150312 21.596 µM 0.0836801882950652 0.451608977525655 no 1497 0.466655354669574 2267 4904905
SGTC_2358 9037157 4 µM 0.082331876142373 0.452149955094958 no 1498 0.467191403480894 2184 2388925
SGTC_497 capsazepine 133 µM 0.0822467796714885 0.452184100982554 no 1499 0.467225237313423 2220 2733484 A calcium channel blocker.
SGTC_332 4112-0506 40.9 µM 0.0808685363320309 0.452737185239433 no 1500 0.467773251178155 2226 2790355
SGTC_1490 4089-0339 670 nM 0.0808253036865851 0.452754535838747 no 1501 0.46779044223411 2272 742542
SGTC_1479 0549-0158 134 µM 0.079788723654764 0.453170574439345 no 1502 0.468202646474869 2247 5440202
SGTC_23 0213-0011 39.996 µM 0.0796174014508078 0.45323934075917 no 1503 0.468270777397964 2250 627608
SGTC_2448 5185112 27.17 µM 0.07785589229741 0.453946466685713 no 1504 0.468971342853559 2177 5718189
SGTC_1902 st060212 70.5 µM 0.0778143184167319 0.453963157539172 no 1505 0.468987878268101 2272 688944
SGTC_2852 9023854 51.95 µM 0.0771233157997193 0.454240589361722 no 1506 0.469262722456444 2238 19798528
SGTC_1562 morin hydrate 59.1 µM 0.0751628049407427 0.455027839308757 no 1507 0.470042588983085 2207 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_279 1273-0055 2.93 µM 0.0748748096568287 0.455143499770749 no 1508 0.470157159632405 2267 2847562
SGTC_1463 k081-0032 34.1 µM 0.0746365951393111 0.455239170881791 no 1509 0.470251928301395 2229 977755
SGTC_695 3505-6186 243 µM 0.0743257253676581 0.455364025515564 no 1510 0.470375603878696 2229 1819379
SGTC_852 0418-0143 439 µM 0.0740471893979322 0.455475897668934 no 1511 0.470486418292528 2275 5369229
SGTC_2701 st077767 14.721 µM 0.0734190258160959 0.455728208415851 no 1512 0.470736339020144 2220 5721188
SGTC_3053 9095903 49.47 µM 0.0732466957327874 0.455797430345688 no 1513 0.470804904166709 2282 17174018
SGTC_2909 7941780 10.49 µM 0.0726178644484887 0.45605003205552 no 1514 0.471055105239042 2277 1243215
SGTC_1184 1269-1718 139 µM 0.0725589012181332 0.456073718514859 no 1515 0.471078566274169 2261 5403821
SGTC_2356 9061756 188.97 µM 0.0721226585959671 0.456248968899245 no 1516 0.471252147113934 2256 20104043
SGTC_731 3966-0296 387 µM 0.0719698848821856 0.45631034421956 no 1517 0.471312937032667 2264 660956
SGTC_2517 totarol 10 µM 0.0718861037170953 0.456344002912178 no 1518 0.471346274532026 2176 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_965 1291-5240 308 µM 0.0718244501828652 0.456368772132316 no 1519 0.471370807318136 2258 2834598
SGTC_818 4072-2707 53.5 µM 0.0717833150242368 0.456385298218392 no 1520 0.471387175621858 2269 882871
SGTC_423 5-fluorouracil 457 µM 0.0709633712491311 0.456714727052014 no 1521 0.471713453737401 2252 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_199 4063-0024 41.6 µM 0.0697373184916137 0.457207373737143 no 1522 0.472201369106464 2261 306215
SGTC_2295 7971645 200 µM 0.0664012473454226 0.458548188735876 no 1523 0.47352918857925 2230 2978226 YKL099C UTP11
SGTC_992 3909-8734 162 µM 0.0649343450896406 0.459137908091628 no 1524 0.474113137430242 2241 4288319
SGTC_3190 9110366 49.47 µM 0.064735200274343 0.459217974615435 no 1525 0.47419241791198 2294 17123768
SGTC_1014 4130-3005 69.3 µM 0.063177203039227 0.459844426990563 no 1526 0.474812698923657 2278 743608
SGTC_2029 5175081 200 µM 0.0625364105811439 0.46010211113078 no 1527 0.475067833609839 2288 1380876
SGTC_2274 7947094 46.08 µM 0.0618418548628679 0.460381434204515 no 1528 0.475344385947552 2300 2971028
SGTC_1956 st077085 54 µM 0.0614725774405316 0.460529951072747 no 1529 0.475491426562179 2229 24208685
SGTC_2557 derrustone 83.84 µM 0.061037274735771 0.460705029214888 no 1530 0.475664761718144 2127 629853 An antioxidant.
SGTC_523 1934-0222 13.7 µM 0.0602410326408704 0.461025296363989 no 1531 0.475981832858404 2290 1361595
SGTC_976 1348-1067 47.6 µM 0.0602408593021933 0.461025366087609 no 1532 0.475981901885169 2306 5310671 YGL099W LSG1
SGTC_730 1436-0052 41.2 µM 0.0599585005767642 0.461138943439851 no 1533 0.476094343467234 2312 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2513 baicalein 25.65 µM 0.0591847720431409 0.461450187999651 no 1534 0.476402469264519 2244 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2145 5634607 200 µM 0.0585208836867913 0.461717266437902 no 1535 0.476666864111454 2259 308662
SGTC_1913 st060213 96.1 µM 0.0572291614236572 0.462236968186071 no 1536 0.477181324382132 2296 688959
SGTC_2349 9023730 187.07 µM 0.0562633630275548 0.462625582370529 no 1537 0.477566002324798 2282 4126287
SGTC_1246 0422-0085 105 µM 0.0549099329248493 0.463170230231579 no 1538 0.478105109244928 2303 264295
SGTC_924 2046-0044 21.3 µM 0.0535255456254052 0.463727407324836 no 1539 0.478656588676856 2322 3623589
SGTC_1273 0849-0096 14.1 µM 0.0499031954144381 0.465185635670121 no 1540 0.480099765452888 2262 5286025
SGTC_821 1114-0266 29.2 µM 0.0495988024023379 0.465308194957137 no 1541 0.480221050501821 2274 3123235
SGTC_1955 wogonin 32.4 µM 0.0493716482677602 0.465399657311883 no 1542 0.480311561001715 2287 5281703 A flavanone.
SGTC_950 1165-0508 94.1 µM 0.0491031596855698 0.465507765109757 no 1543 0.480418542690978 2259 6148369
SGTC_1401 3807-4679 7.6 µM 0.0489301736365291 0.465577419852039 no 1544 0.480487471284938 2313 3291456
SGTC_3170 9103054 49.47 µM 0.0488255740885437 0.465619538526513 no 1545 0.480529150650402 2280 16432970
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0486665860031226 0.465683558349513 no 1546 0.480592502407361 2279 688761
SGTC_1505 k297-0037 20.6 µM 0.0479347608579809 0.465978254224875 no 1547 0.480884118031573 2284 4089396
SGTC_1005 4092-0690 4.4 µM 0.0478254588914877 0.466022270221907 no 1548 0.480927673253412 2265 1529343
SGTC_1145 3546-0597 10.2 µM 0.046765254651993 0.466449236879244 no 1549 0.481350160745568 2228 875334
SGTC_291 SEC14.278 35.5 µM 0.0467494162509618 0.46645561563209 no 1550 0.481356472450143 2310 1068044
SGTC_1125 tnp00248 1.32998 µM 0.0465290159768492 0.466544380465354 no 1551 0.48144430385979 2312 24207736
SGTC_2900 5328528 85.29 µM 0.0456257517529008 0.466908181825323 no 1552 0.481804271805447 2315 795359
SGTC_773 4358-1457 44.6 µM 0.0447356166240711 0.467266722321498 no 1553 0.482159022072235 2329 1186886
SGTC_2555 cholic acid 100 µM 0.0441247837176982 0.467512777128643 no 1554 0.482402468735391 2256 6708657 Influences liver metabolism.
SGTC_888 0916-0002 6.97 µM 0.0433648239738017 0.46781892030674 no 1555 0.482705358856206 2320 2802138 YIL048W NEO1
SGTC_1344 1488-0097 29.1 µM 0.0391485140914547 0.469517764889141 no 1556 0.484385990970255 2300 747966
SGTC_229 benomyl 22.8748 µM 0.0375113145891256 0.470177580124284 no 1557 0.485038659379758 2270 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1610 st001799 48.1 µM 0.0363274635577804 0.470654740446445 no 1558 0.485510625817813 2323 621897
SGTC_723 4182-0001 115 µM 0.0350666061767938 0.471162985094123 no 1559 0.486013314718535 2284 744821 YLR208W SEC13
SGTC_2645 abamectin 100 µM 0.0344267690319218 0.471420917931765 no 1560 0.486268418759682 2330 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_394 menadione 8.33 µM 0.0341708515039134 0.471524087443141 no 1561 0.486370455045795 2354 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3029 9088683 49.47 µM 0.0331244914602441 0.471945932417221 no 1562 0.486787656051503 2306 25236615
SGTC_2972 9093619 59.92 µM 0.033028386808552 0.471984679044953 no 1563 0.486825975293058 2338 25236256
SGTC_2942 9052777 62.25 µM 0.0326129187946736 0.472152186828664 no 1564 0.486991633801447 2335 6469503
SGTC_272 doxorubicin 8.13 µM 0.0324409299019715 0.47222153050112 no 1565 0.487060211155376 2343 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3028 9087778 49.47 µM 0.0312620487675604 0.472696862513864 no 1566 0.4875302781502 2349 17217395
SGTC_1461 k072-0203 53.8 µM 0.0312084779659233 0.472718463514263 no 1567 0.487551639384968 2340 5418714
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0305059708074847 0.473001738235407 no 1568 0.487831765791503 2357 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2585 alliin 100 µM 0.0295981613338178 0.473367818018422 no 1569 0.488193765857802 2327 87310 A garlic compound which reacts with lipids.
SGTC_2199 6590217 200 µM 0.0282881911350269 0.473896111167696 no 1570 0.488716149470679 2330 703109
SGTC_1597 7-benzyloxygramine 47.5 µM 0.0282638984764261 0.473905908502678 no 1571 0.488725836965779 2362 260807
SGTC_1408 3909-7976 48.8 µM 0.0271417865594896 0.474358478229128 no 1572 0.489173323085322 2347 24152374
SGTC_2308 7584454 197.62 µM 0.0268608362439271 0.474471796200023 no 1573 0.489285365193763 2349 893577
SGTC_1117 retinoic acid 1.10837 µM 0.0256311406009034 0.474967803505731 no 1574 0.489775773808355 2349 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2929 9013348 24.6 µM 0.0236015584105741 0.475786535776277 no 1575 0.490585214533348 2358 2995952
SGTC_2234 tolnaftate 200 µM 0.0235748284765762 0.475797319305774 no 1576 0.490595875267928 2358 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2056 5235370 200 µM 0.0233692607629503 0.47588025109762 no 1577 0.490677862332274 2346 5511916
SGTC_1352 1496-0991 99 µM 0.0228445173506344 0.476091952064083 no 1578 0.490887148783968 2350 3000039
SGTC_205 1486-1330 71.903 µM 0.0227693510551373 0.476122277491202 no 1579 0.490917127999344 2350 4118834
SGTC_2037 5169046 200 µM 0.0225956470506457 0.476192357942043 no 1580 0.490986408046486 2340 5718022
SGTC_258 haloperidol 50.781 µM 0.0216080953561351 0.47659079716039 no 1581 0.491380287940028 2358 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3138 9097216 49.47 µM 0.0180403981919447 0.478030418209594 no 1582 0.49280331277554 2385 25237486
SGTC_575 k072-0246 11.9 µM 0.0180392549038873 0.478030879590986 no 1583 0.492803768807274 2369 6796779
SGTC_36 0335-0881 14.2 µM 0.0170539597341089 0.478428512797858 no 1584 0.49319678418716 2361 23828853
SGTC_3151 9099821 49.47 µM 0.0159929908687019 0.478856709455446 no 1585 0.493619991728801 2366 17174189
SGTC_2813 7971799 71.43 µM 0.01453957549663 0.479443333201556 no 1586 0.494199752957343 2358 2234054
SGTC_1081 sertraline 6 µM 0.0131188445827791 0.480016807979857 no 1587 0.494766488344466 2386 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2827 7993847 71.43 µM 0.0129129535529504 0.480099918881992 no 1588 0.494848620023867 2367 2985692
SGTC_2822 7994718 71.43 µM 0.012708588302698 0.480182414736595 no 1589 0.494930143272792 2383 1018011
SGTC_3229 9132204 49.47 µM 0.012641676169774 0.480209425254837 no 1590 0.494956835207447 2381 17682924
SGTC_371 0195-0006 7.36 µM 0.0125888995638709 0.480230729728388 no 1591 0.494977888351632 2352 3928593
SGTC_2018 5133068 143 µM 0.0119853279377857 0.480474379100542 no 1592 0.495218660413128 2380 785362
SGTC_2850 9015429 58.44 µM 0.0119713630554062 0.480480016521195 no 1593 0.495224231195486 2371 6457570
SGTC_1156 4092-0367 4.88 µM 0.0115824120749395 0.480637031960339 no 1594 0.495379389425405 2375 1357585
SGTC_672 1441-0018 53.7 µM 0.0108546676808533 0.480930822804018 no 1595 0.495669699157992 2388 251141
SGTC_587 k089-0003 57 µM 0.0101938594285361 0.481197600464328 no 1596 0.495933308905155 2385 9659696
SGTC_1372 2752-0194 270 µM 0.00953213745941974 0.481464755443206 no 1597 0.496197284931751 2388 823334
SGTC_459 nigericin 15.3 µM 0.00930122916969417 0.481557981303346 no 1598 0.496289399927023 2372 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_837 0091-0265 12.5 µM 0.00884173055111097 0.481743500175979 no 1599 0.496472705809713 2384 759367
SGTC_2540 epiandrosterone 100 µM 0.00655398212945207 0.482667218257785 no 1600 0.497385358142098 2392 441302 A steroid.
SGTC_3313 9133968 57.047 µM 0.00642365566263855 0.482719842676146 no 1601 0.497437349785369 2394 1494643
SGTC_1227 3909-8010 46.6 µM 0.00640819801004804 0.482726084329141 no 1602 0.49744351636962 2393 15982272
SGTC_954 1189-0853 2.85 µM 0.00558324184776696 0.483059199879252 no 1603 0.497772620337424 2389 2828194
SGTC_960 1222-0186 7.7 µM 0.0032778802017618 0.483990161991171 no 1604 0.498692317339159 2397 3126296
SGTC_1187 1391-0724 117 µM 0.00156421493630554 0.484682239291475 no 1605 0.499375968780749 2399 6997986
SGTC_1163 k060-0048 49.9 µM 0.000518721814047296 0.485104492773685 no 1606 0.49979305994589 2402 6809982
SGTC_980 1473-0395 201 µM -0.000262413896097084 0.48541998858314 no 1607 0.499895312003084 2407 768876
SGTC_643 k048-0106 28.4 µM -0.000422796622242433 0.485484767295183 no 1608 0.499831328556402 2408 6763920
SGTC_255 tunicamycin 200.472 nM -0.00190916379182145 0.486085130190921 no 1609 0.499238354305919 2407 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3125 9127534 49.47 µM -0.00207962340481903 0.486153983071632 no 1610 0.499170350894521 2409 1639235
SGTC_284 0988-0104 32.6 µM -0.00303809930561285 0.486541142972764 no 1611 0.49878797559944 2406 4666532
SGTC_82 0054-0107 293.755 µM -0.0038347286369059 0.486862937397013 no 1612 0.498470168362272 2421 3104697
SGTC_1247 0448-0043 5.84 µM -0.00422521555795003 0.487020675767998 no 1613 0.498314387885509 2415 3089013 YGL099W LSG1
SGTC_2221 6807166 181.081 µM -0.00447162059423326 0.487120212873021 no 1614 0.498216087428053 2413 674925
SGTC_1512 0259-0544 12.2 µM -0.00454518400833245 0.487149929504537 no 1615 0.498186740170138 2416 18476
SGTC_188 3229-0966 278.469 µM -0.00495639837282786 0.487316044715805 no 1616 0.498022691226293 2417 5722370
SGTC_1468 k284-1086 134 µM -0.0052351012692053 0.487428631506885 no 1617 0.497911506301178 2418 15996457
SGTC_2625 euphol 100 µM -0.00621850182166858 0.487825900886109 no 1618 0.497519192691299 2421 6708538 A triterpene alcohol.
SGTC_816 0325-0417 81.3 µM -0.00761730914400366 0.488391004991326 no 1619 0.496961162706875 2429 68101
SGTC_970 1315-0089 19.5 µM -0.00768069904056956 0.488416614433289 no 1620 0.49693587453677 2427 6811083 YLR033W RSC58
SGTC_2012 4023501 200 µM -0.00783647484530945 0.488479547873701 no 1621 0.496873730852477 2417 3477460
SGTC_290 2043-6722 48.1 µM -0.00816444055755028 0.488612046989474 no 1622 0.496742895651201 2429 773758 YLR208W SEC13
SGTC_3224 9130643 49.47 µM -0.00876149888664685 0.488853263533268 no 1623 0.496504712373114 2437 17644395
SGTC_3335 9143315 29.6265 µM -0.00894138202232169 0.488925938623408 no 1624 0.496432952196047 2433 4899691
SGTC_3061 glucosamine 200 µM -0.00988448525436925 0.489306970366731 no 1625 0.496056725123795 2415 91431 and experimental redox chemotherapeutic
SGTC_118 0083-0097 135.343 µM -0.0122208555699989 0.490250949957633 no 1626 0.495124705364399 2432 5207356
SGTC_783 0848-0141 92.7 µM -0.0126777105475919 0.490435542730665 no 1627 0.494942460722518 2427 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3337 9144342 33.5465 µM -0.0128314559852355 0.490497664212177 no 1628 0.494881130155897 2446 17682949
SGTC_2774 tamoxifen 10.92 µM -0.0128607846102587 0.490509514590939 no 1629 0.494869430692728 2425 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1612 st002233 45.4 µM -0.0138468155403408 0.49090793016707 no 1630 0.494476096352903 2431 1035021
SGTC_367 0335-0881 7.1 µM -0.0143553231794331 0.491113401292206 no 1631 0.494273251325818 2436 23828853
SGTC_2017 5132927 60.65 µM -0.0146492699724418 0.491232176552101 no 1632 0.494155995853356 2439 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1963 st076565 50.3 µM -0.0153498207890356 0.491515251662488 no 1633 0.493876547956511 2429 4914280
SGTC_876 0720-0963 56.8 µM -0.0154422078547226 0.491552583293234 no 1634 0.493839695217854 2439 765861
SGTC_1905 st060207 84.5 µM -0.0162628192833723 0.491884177972129 no 1635 0.493512359765011 2438 1948547
SGTC_1840 st055363 71 µM -0.01671607249014 0.492067332058759 no 1636 0.493331562479878 2463 676033
SGTC_1120 ficusin 1.78878 µM -0.0167661468380094 0.492087566594617 no 1637 0.493311588504548 2480 6199 A DNA cross-linker.
SGTC_1464 k208-0027 110 µM -0.0173541837346161 0.492325187847102 no 1638 0.493077029863975 2426 X1464
SGTC_1471 k673-0312 37 µM -0.0177650083446397 0.49249120057895 no 1639 0.492913159824103 2439 24099884
SGTC_2920 7982904 15.77 µM -0.017933094628939 0.492559124012112 no 1640 0.492846113779524 2444 6456808
SGTC_1172 0370-0043 85 µM -0.0182244827811949 0.492676874068276 no 1641 0.492729885721685 2460 376585
SGTC_554 4483-2211 187 µM -0.018262556534673 0.49269225973298 no 1642 0.492714699019125 2467 747107
SGTC_1789 tunicamycin 25 nM -0.0186957044149 0.49286729624428 no 1643 0.492541927518761 2480 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_416 estradiol valerate 100 µM -0.0190274588266109 0.493001360245397 no 1644 0.492409600198255 2462 13791 A steroid.
SGTC_1983 st071813 46.9 µM -0.0191868973197195 0.49306579060466 no 1645 0.49234600505215 2480 11838595
SGTC_1680 diphenhydramine 100 µM -0.0193011184338774 0.493111948373875 no 1646 0.492300445857214 2492 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2832 7992762 51.95 µM -0.0195150564450156 0.493198402876664 no 1647 0.492215113012189 2450 2985177
SGTC_871 0574-0004 149 µM -0.0198650136172321 0.493339824777862 no 1648 0.492075527361699 2469 9551173
SGTC_2371 9071574 200 µM -0.0209045764563588 0.493759929488786 no 1649 0.491660887969254 2445 45596039
SGTC_2506 ethyl hematommate 54.16 µM -0.0224794772082356 0.494396386226216 no 1650 0.491032741339504 2480 3940691 An allergen.
SGTC_2451 5856223 45.7 µM -0.0244936956029005 0.49521040276636 no 1651 0.490229406193993 2461 2179896
SGTC_699 0375-0592 111 µM -0.0251251425140452 0.495465596951564 no 1652 0.489977572842048 2445 762578
SGTC_3311 9131146 2.8755 µM -0.0255754016925706 0.495647566712832 no 1653 0.489798003128391 2489 4900406 YPR165W RHO1
SGTC_521 r062-0005 13.8 µM -0.0257540142542379 0.495719752246557 no 1654 0.489726770489348 2443 2832033
SGTC_2753 fluvastatin 17.09 µM -0.0267511179224845 0.496122730110347 no 1655 0.48932912074777 2478 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_902 1120-0002 2.07 µM -0.0270370933773713 0.496238307384335 no 1656 0.4892150743 2470 3280475
SGTC_3153 9100258 49.47 µM -0.0271509714616724 0.496284331417579 no 1657 0.48916966018939 2472 25236848
SGTC_705 1124-0212 310 µM -0.0275961574851563 0.496464254621107 no 1658 0.48899212319121 2455 9554485
SGTC_1111 tnp00062 510.699 nM -0.0276720273711764 0.496494917725082 no 1659 0.488961867040531 2464 676306
SGTC_3336 9143619 71.43 µM -0.0278429633090407 0.496564002212316 no 1660 0.488893699733542 2449 45595730
SGTC_3139 9095020 49.47 µM -0.0278609747836526 0.496571281632521 no 1661 0.488886516981274 2446 25236292
SGTC_2775 cyproheptadine 69.59 µM -0.0281927358775886 0.496705364604325 no 1662 0.488754215426464 2451 2913 A selective serotonin reuptake inhibitor.
SGTC_49 0717-0965 32.132 µM -0.0282089632297835 0.496711922982793 no 1663 0.488747744223321 2641 5889349 YGL099W LSG1
SGTC_72 0744-0168 198.391 µM -0.0284879208988472 0.496824665479465 no 1664 0.488636500923489 2501 677577
SGTC_2744 captopril 92.04 µM -0.0285007528306846 0.496829851591604 no 1665 0.488631383801128 2468 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3040 9091894 49.47 µM -0.0287465191818642 0.496929179828916 no 1666 0.488533377369962 2479 25236966
SGTC_1501 4491-0275 38.4 µM -0.0291995431632392 0.497112273221506 no 1667 0.488352722791242 2453 5104718
SGTC_375 3970-0961 9.27 µM -0.0295375719563169 0.497248890755107 no 1668 0.488217926958391 2473 2898222
SGTC_2305 7443522 69.23 µM -0.0295610055279493 0.497258361666847 no 1669 0.488208582396428 2475 5415886
SGTC_2212 7123476 200 µM -0.03012332292981 0.497485628305409 no 1670 0.487984350080585 2455 1085715
SGTC_440 fluspirilene 35.1 µM -0.0302140730312587 0.49752230601541 no 1671 0.487948162499996 2653 3396 An atypical antipsychotic.
SGTC_1852 st056254 31.4 µM -0.0311213920748558 0.497889010670078 no 1672 0.487586364761269 2508 442583
SGTC_75 0159-0059 199.013 µM -0.0330199979319025 0.498656362039116 no 1673 0.486829320146198 2463 5377270
SGTC_657 3534-0529 86.7 µM -0.0332298717318363 0.498741186187593 no 1674 0.486745638536901 2474 1049549
SGTC_3317 9138495 8.753 µM -0.0346136691856747 0.499300473255136 no 1675 0.486193900798971 2456 17020139
SGTC_397 arbidol 50 µM -0.0347766753560973 0.499366355294084 no 1676 0.486128909874044 2566 131410 A RNA synthesis inhibitor.
SGTC_1954 st077032 68.9 µM -0.0352554133848257 0.499559846451902 no 1677 0.485938038087025 2528 698907
SGTC_2060 5238662 140 µM -0.0358528790855543 0.499801323815843 no 1678 0.485699834365387 2506 790130
SGTC_1628 st004252 77.7 µM -0.0368360119862624 0.499801323815843 no 1679 0.485307880055214 2494 692968
SGTC_1977 st070720 65.3 µM -0.0373918661837158 0.499576664544718 no 1680 0.485086278991112 2544 682188
SGTC_1334 1486-0610 236 µM -0.038174378192312 0.499260397360428 no 1681 0.484774324620866 2583 3742339
SGTC_315 k915-0449 187 µM -0.0382081897689704 0.499246731774534 no 1682 0.484760845587041 2503 20970215 YNL149C PGA2
SGTC_2314 7727897 200 µM -0.0382623936972401 0.499224824237289 no 1683 0.484739237149161 2484 900724
SGTC_2272 7805186 180 µM -0.0389002260353747 0.498967032492914 no 1684 0.484484968178321 2471 2956062 YPR165W RHO1
SGTC_661 1304-0007 33.6 µM -0.0393829274661244 0.498771940056825 no 1685 0.48429254562886 2498 3117130
SGTC_1994 st072947 40.9 µM -0.0408953813037059 0.498160656842877 no 1686 0.483689649777332 2584 5286565 YDL195W SEC31
SGTC_2025 5147754 141 µM -0.041176016504002 0.498047233920905 no 1687 0.483577786755263 2505 315777 YLR208W SEC13
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0425305731636841 0.497499771930804 no 1688 0.483037869966563 2545 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1077 5-fluorocytosine 377 nM -0.0425580369391602 0.497488672127912 no 1689 0.483026923416557 2521 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1788 fluconazole 20 µM -0.0427957009610957 0.497392617543396 no 1690 0.48293219549389 2557 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1329 1447-1697 50.6 µM -0.042887499311004 0.49735551624913 no 1691 0.482895606843719 2576 2840515
SGTC_2569 tetrandrine 100 µM -0.0441669470688412 0.496838416148546 no 1692 0.48238566437457 2521 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1112 tnp00069 1.16933 µM -0.044807545735932 0.496579514486158 no 1693 0.48213035525397 2591 145826
SGTC_1590 st077108 57.8 µM -0.0451150623715406 0.496455230361455 no 1694 0.482007797805304 2463 5489485
SGTC_189 3970-0742 2.116 µM -0.0464086071599034 0.49593244277465 no 1695 0.481492288192301 2495 2891807
SGTC_633 0437-0093 97.7 µM -0.0467594740080996 0.495790640708515 no 1696 0.481352464368759 2474 2831118
SGTC_1320 1313-0481 95.3 µM -0.047333305544108 0.49555872910785 no 1697 0.481123791917983 2493 6813365 YLR208W SEC13
SGTC_3235 9132602 49.47 µM -0.0474205948962603 0.495523451613065 no 1698 0.481089007564758 2558 4912240
SGTC_933 2914-0560 114 µM -0.0480213566816714 0.495280658121513 no 1699 0.480849611034798 2483 463887
SGTC_1241 0364-0022 50.8 µM -0.0483589977548729 0.495144203707261 no 1700 0.480715068050598 2551 4563895
SGTC_2171 5739187 198.077 µM -0.0493398021775502 0.494747824249205 no 1701 0.480324250288675 2489 2262761
SGTC_1400 3771-8998 51.5 µM -0.0495280563844225 0.494671744320503 no 1702 0.48024923943473 2522 670767
SGTC_1822 st052468 42 µM -0.0496437065458504 0.494625006252207 no 1703 0.480203158381581 2510 2873678
SGTC_3115 9123671 49.47 µM -0.0512786857882293 0.493964265075832 no 1704 0.479551726016519 2495 3286988
SGTC_319 1348-1596 45.5 µM -0.0514282345513372 0.493903829006388 no 1705 0.479492143308908 2594 5380505
SGTC_1070 indatraline 8.81 µM -0.05149812114233 0.493875586287312 no 1706 0.479464299488961 2513 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3093 9117344 49.47 µM -0.051660516180761 0.493809958974792 no 1707 0.479399599364293 2627 24824913
SGTC_365 0121-0052 13.6 µM -0.051783926563468 0.4937600863084 no 1708 0.479350431555397 2540 3101739
SGTC_963 1269-2853 151 µM -0.0520605429105026 0.493648300325558 no 1709 0.479240226251887 2527 3668223
SGTC_1941 st076221 61.8 µM -0.0522637752874501 0.493566170532944 no 1710 0.479159258491297 2508 2828568
SGTC_193 1273-0060 1.558 µM -0.0522650179881277 0.493565668336489 no 1711 0.479158763402101 2493 2847393 YHR072W ERG7
SGTC_757 1066-0008 322 µM -0.0529302875102965 0.493296823105481 no 1712 0.478893726134937 2639 6842497
SGTC_956 1185-0240 191 µM -0.0530478423258296 0.493249317782869 no 1713 0.47884689434307 2528 1416193
SGTC_1962 st076595 64.5 µM -0.0533278894326357 0.493136147747207 no 1714 0.47873532962913 2511 279619
SGTC_742 0kpi-0133 140 µM -0.0555453817023419 0.492240055615629 no 1715 0.477851988180845 2551 2728852
SGTC_2991 9074669 71.4286 µM -0.0571120952192819 0.491606967547399 no 1716 0.477227950779598 2552 17333109
SGTC_3011 9081274 71.4286 µM -0.0575819139562804 0.491417124100385 no 1717 0.477040828169211 2537 6625322
SGTC_1183 1254-0324 198 µM -0.0576443861423337 0.491391880605723 no 1718 0.477015946701353 2558 5799357
SGTC_2624 nerol 100 µM -0.0578469048597612 0.491310047943148 no 1719 0.476935288015303 2499 637566 A natural product oil.
SGTC_627 1391-0720 175 µM -0.0582931528670468 0.491129731769653 no 1720 0.476757560731487 2553 997839
SGTC_1284 0929-0043 16 µM -0.05840429778354 0.49108482153917 no 1721 0.476713295740952 2564 1239883
SGTC_2436 5633522 8.09 µM -0.059945961195725 0.4904618948425 no 1722 0.476099336974426 2531 5724242
SGTC_2387 9077560 195.08 µM -0.0604908841608912 0.490241717985459 no 1723 0.475882337970873 2500 5303272
SGTC_2049 5262831 67.185 µM -0.0605102781617961 0.490233881867706 no 1724 0.475874615031085 2529 763417
SGTC_678 1218-2179 85.9 µM -0.0614423529907697 0.489857282893516 no 1725 0.475503461623282 2514 6820081 YOR116C RPO31
SGTC_247 mechlorethamine 29.705 µM -0.0616097820133212 0.489789635197948 no 1726 0.475436793411613 2505 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0643356874887907 0.48868830837974 no 1727 0.474351468897902 2555 23847180
SGTC_819 1013-0258 27.7 µM -0.0649043653848687 0.488458560376665 no 1728 0.474125072425358 2529 5753198
SGTC_898 1000-0849 28.3 µM -0.0651859398219304 0.488344804660796 no 1729 0.474012977857573 2487 6751807
SGTC_2629 bisabolol 100 µM -0.0652891051893734 0.488303126219893 no 1730 0.473971908318329 2565 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_655 k060-0012 42 µM -0.0653353406127503 0.488284447314996 no 1731 0.473953502352028 2523 5994525
SGTC_1746 st038117 42 µM -0.0656492992569421 0.488157610104371 no 1732 0.473828519304096 2589 2898218
SGTC_1740 st038286 13.222 µM -0.0669344809323293 0.487638417852903 no 1733 0.473316931382734 2597 716786
SGTC_717 1532-0246 73.2 µM -0.0671866905926005 0.487536531731162 no 1734 0.473216540275509 2556 9561992
SGTC_2783 7738165 71.43 µM -0.0672567320934539 0.487508236936474 no 1735 0.473188660820915 2574 17201110
SGTC_3340 9146634 11.102 µM -0.0673165635380999 0.487484066766874 no 1736 0.473164845500867 2554 4907387
SGTC_362 0310-0100 9.03 µM -0.0677987816737521 0.487289266301699 no 1737 0.472972906808038 2585 790235
SGTC_1148 3909-7663 27.7 µM -0.0677988221475107 0.487289249951742 no 1738 0.472972890698412 2663 4084526
SGTC_3333 9141820 12.094 µM -0.0680489690564456 0.48718819991668 no 1739 0.472873326463048 2569 1939433
SGTC_3049 9092223 49.47 µM -0.0683067247574853 0.4870840770735 no 1740 0.47277073552602 2611 8623917
SGTC_3014 9081533 49.47 µM -0.0688770876815638 0.486853676738028 no 1741 0.472543728289565 2551 21367265
SGTC_1765 st044815 90.4 µM -0.0701530112119495 0.486338278436151 no 1742 0.472035936875418 2593 645695
SGTC_3111 9122088 49.47 µM -0.0706332798501216 0.486144283928141 no 1743 0.471844811530299 2601 16876704
SGTC_548 1436-0017 110 µM -0.0717946632055376 0.485675180965075 no 1744 0.471382660003515 2536 9677137
SGTC_2978 9011784 42.97 µM -0.0720600056300613 0.485568007297195 no 1745 0.471277077164047 2684 2994934
SGTC_529 4076-0302 30.3 µM -0.0720811557826888 0.485559464646838 no 1746 0.471268661358888 2549 5816522
SGTC_2079 5212404 121 µM -0.0729113156572765 0.485224164277246 no 1747 0.470938344659831 2535 758462
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0749824261953535 0.484387691791555 no 1748 0.470114347194865 2623 6708760
SGTC_1345 1488-0192 31.4 µM -0.0757779298980695 0.484066424750706 no 1749 0.469797887509423 2549 658348
SGTC_943 3253-1379 105 µM -0.0765806218235174 0.483742265205069 no 1750 0.46947858760994 2614 668464
SGTC_221 trifluoperazine 10.304 µM -0.0768467930725284 0.483634776824303 no 1751 0.469372712640714 2547 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_788 1182-0090 188 µM -0.0770771821299483 0.483541739385805 no 1752 0.469281072506268 2752 5715185
SGTC_1188 1403-0014 4.57 µM -0.0772393220128639 0.483476263378193 no 1753 0.469216580311495 2552 9614867
SGTC_1180 1193-0155 285 µM -0.0778761324424529 0.483219108247959 no 1754 0.468963292645642 2613 2921347
SGTC_1132 3456-3614 2.5 µM -0.0785617988605374 0.482942232027014 no 1755 0.468690586839081 2685 3125502
SGTC_2170 morpholine 200 µM -0.0793098601837804 0.48264016975587 no 1756 0.468393081857816 2617 121171 Reacts with secondary amines.
SGTC_112 phenothiazine 287.218 µM -0.0797962474017146 0.482443775112352 no 1757 0.468199654474077 2541 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_106 0092-0003 11.579 µM -0.08063008302066 0.482107096825446 no 1758 0.467868070648414 2661 1072148
SGTC_164 4100-3994 89.624 µM -0.0809747797105984 0.481967922158956 no 1759 0.467731004750594 2537 4615967
SGTC_2137 5261020 140 µM -0.0815397978499805 0.481739795309266 no 1760 0.467506338062903 2556 763655
SGTC_3059 1327-0034 3 µM -0.0816811332239286 0.481682731889902 no 1761 0.467450140862729 2573 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_285 1486-1325 46 µM -0.0821492077099394 0.481493751945785 no 1762 0.467264031615581 2608 22310230
SGTC_1830 st055982 50.3 µM -0.0822063738683551 0.481470672019914 no 1763 0.46724130249473 2541 455313 An antimicrobial agent.
SGTC_2526 patulin 37.61 µM -0.0829217795457524 0.481181843650194 no 1764 0.466956868052636 2638 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1020 4335-0961 93.3 µM -0.0839363161574254 0.480772265109969 no 1765 0.466553532654926 2542 669075
SGTC_1140 3229-1848 2.98 µM -0.0850777493376037 0.480311481445958 no 1766 0.466099789808045 2559 2849525
SGTC_3240 9133527 49.47 µM -0.0860706930541137 0.479910662673189 no 1767 0.465705110350908 2545 17617455
SGTC_1131 3454-3128 32.3 µM -0.0866325043915792 0.479683886856301 no 1768 0.46548181412673 2758 710982
SGTC_2469 5655019 90.81 µM -0.0872247477430727 0.479444834241873 no 1769 0.465246434233367 2714 2788239
SGTC_1699 st031318 29.054 µM -0.0872717117302205 0.479425878052374 no 1770 0.465227769488989 2635 5340658
SGTC_2644 guaiazulene 100 µM -0.0890320156951495 0.478715396174256 no 1771 0.464528233149363 2624 3515 A coloring agent.
SGTC_1406 3909-7906 11.9 µM -0.0897623766971665 0.478420632570936 no 1772 0.464238023250423 2579 X1406
SGTC_391 gliotoxin 8.33 µM -0.0899345990360106 0.478351127729709 no 1773 0.464169593245294 2666 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2059 5238311 157 µM -0.0904624492077424 0.478138104060989 no 1774 0.463959866379268 2580 703021
SGTC_626 0214-0009 33 µM -0.0911907716061286 0.477844186395961 no 1775 0.463670503796503 2641 3437874
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0943455250929093 0.476571213121243 no 1776 0.462417343685593 2613 4330530
SGTC_3106 9121286 49.47 µM -0.0955920401894094 0.476068297497385 no 1777 0.461922293629042 2767 15943471
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0960520741992097 0.475882703002497 no 1778 0.461739607242891 2685 5282362
SGTC_3131 9127911 49.47 µM -0.0969700220107946 0.475512385058195 no 1779 0.461375100598637 2770 45595681
SGTC_1725 st036284 20.55 µM -0.0970196158134509 0.475492378556064 no 1780 0.461355408384252 2758 707914
SGTC_3056 9094900 49.47 µM -0.0990907209036916 0.474656935420753 no 1781 0.460533119737165 2633 25236784
SGTC_2661 dactinomycin 12.96 µM -0.0993864598487481 0.474537649141963 no 1782 0.460415716505135 2593 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2063 5246145 200 µM -0.100799226205539 0.473967841632373 no 1783 0.459854920556028 2672 711240
SGTC_170 4197-0004 226 µM -0.101230240913622 0.473794012099716 no 1784 0.459683845619479 2697 218692
SGTC_555 4296-0685 37 µM -0.101352307266448 0.473744783276412 no 1785 0.459635397366591 2570 2908540 YHR072W ERG7
SGTC_1066 ketoconazole 628 nM -0.101446384272137 0.473706842707268 no 1786 0.459598058521462 2707 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_729 4092-0585 94.1 µM -0.101989931900662 0.473487638599847 no 1787 0.459382333294933 2578 2169061
SGTC_281 1672-3440 14.9 µM -0.103924318032474 0.472707597039137 no 1788 0.458614704298908 2667 6833000
SGTC_1114 scopoletin 1.73284 µM -0.104188510736201 0.472601069339279 no 1789 0.458509875726683 2581 5280460 A coumarin with genotoxic properties.
SGTC_230 MPP+ 141.667 µM -0.105163349148067 0.472208012313557 no 1790 0.458123096278854 2630 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1932 st074806 40.9 µM -0.105306023245721 0.47215048805984 no 1791 0.458066491846726 2822 17251235
SGTC_1824 st053723 68.6 µM -0.106490596375018 0.471672906847807 no 1792 0.457596557995277 2636 675225
SGTC_1572 epiandrosterone 68.9 µM -0.107470818976543 0.471277743862871 no 1793 0.457207737151535 2624 441302 A steroid.
SGTC_833 3852-0053 558 µM -0.10750031872278 0.471265851890538 no 1794 0.457196036242265 2710 3123681
SGTC_1084 voriconazole 435 nM -0.10769734116483 0.471186428629898 no 1795 0.457117889345109 2616 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_382 3229-0966 23.2 µM -0.108775253669459 0.47075192324147 no 1796 0.456690376021363 2710 5722370
SGTC_1024 4507-0395 26 µM -0.110772700596144 0.469946846926915 no 1797 0.455898296932149 2764 4201836
SGTC_1514 1189-1591 158 µM -0.111972162194155 0.469463459547248 no 1798 0.455422739543853 2792 767698 YMR146C TIF34
SGTC_254 nsc-64875 3.808 µM -0.112047463073864 0.469433114513216 no 1799 0.455392886697666 2758 56993
SGTC_750 4073-0104 132 µM -0.112635087717826 0.46919631741846 no 1800 0.455159933036432 2651 22330957
SGTC_76 0433-0009 400.328 µM -0.11291801476145 0.469082309229289 no 1801 0.455047776980695 2769 2841569
SGTC_2532 xanthone 78.9 µM -0.113156686339017 0.468986136179187 no 1802 0.454953167168126 2695 7020 An insecticide.
SGTC_251 melphalan 456.522 µM -0.114675469316123 0.46837418305936 no 1803 0.454351179141546 2668 460612 A DNA alkylator.
SGTC_1880 MG-132 525 µM -0.11481156395257 0.468319350979321 no 1804 0.454297241481898 2651 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2952 9073731 13.78 µM -0.115319366369523 0.468114764373907 no 1805 0.454095994311821 2634 16457353
SGTC_3156 9099931 49.47 µM -0.11532888124719 0.468110931040842 no 1806 0.454092223583076 2627 18111053
SGTC_2391 6285546 200 µM -0.115819552924669 0.467913254326563 no 1807 0.453897776904392 2594 846083
SGTC_1820 st053765 18.6 µM -0.116027867838202 0.467829332965339 no 1808 0.453815227805548 2681 3690829
SGTC_147 4466-0538 29.23 µM -0.117776924318174 0.467124768063017 no 1809 0.453122206998606 2792 6742687 YHR072W ERG7
SGTC_478 N-arachidonylglycine 10 µM -0.11781153195458 0.467110828249456 no 1810 0.453108496003277 2616 5283389
SGTC_2364 9055074 200 µM -0.121409067385649 0.465661979009239 no 1811 0.451683517637221 2690 6470630
SGTC_2412 st077135 33.4 µM -0.121523729020051 0.465615808270267 no 1812 0.451638110472537 2913 13258915
SGTC_884 0851-0618 334 µM -0.123174506667932 0.464951142121944 no 1813 0.450984456276589 2766 9642473
SGTC_1210 3013-0140 750 nM -0.125354528078792 0.464073532340706 no 1814 0.450121442707671 2765 905973
SGTC_1763 st044482 94.5 µM -0.125356038080419 0.464072924520426 no 1815 0.450120845018702 2747 88505
SGTC_3243 9134147 49.47 µM -0.126834264068803 0.463477935315329 no 1816 0.449535787962216 2640 24282180
SGTC_751 0833-0568 350 µM -0.128112100954461 0.46296366893907 no 1817 0.449030129893154 2689 6954252
SGTC_990 3985-0011 41.3 µM -0.130013963155305 0.462198377991028 no 1818 0.448277689729785 2716 5399565 YGL099W LSG1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.13004107251311 0.46218747045247 no 1819 0.448266965701437 2679 688788
SGTC_1357 1503-1303 39.5 µM -0.130963194396024 0.461816468692218 no 1820 0.447902211597969 2658 292895
SGTC_2288 7946289 167.31 µM -0.131617607694467 0.461553195558429 no 1821 0.447643378881358 2735 1246052
SGTC_3238 9133470 49.47 µM -0.132769333523517 0.461089892555315 no 1822 0.447187903953087 2753 3534688
SGTC_1892 st058411 7.36 µM -0.133420557770644 0.460827948895398 no 1823 0.446930394001657 2763 3934738
SGTC_1003 4049-0218 100 µM -0.133851301226238 0.460654699141993 no 1824 0.446760079819683 2772 295161
SGTC_88 0180-0332 8.668 µM -0.134878524051014 0.460241569031288 no 1825 0.446353959848361 2629 3101745
SGTC_2766 oltipraz 83.91 µM -0.136363804155816 0.459644292719883 no 1826 0.445766843221669 2738 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.136697779035149 0.459510003754118 no 1827 0.445634842563028 2752 6708739 YPR165W RHO1
SGTC_471 1-acyl-paf 4 µM -0.137306479657313 0.459265261379297 no 1828 0.445394274461105 2634 16759367
SGTC_2087 5276107 200 µM -0.137732690872909 0.459093902337699 no 1829 0.445225841017914 2650 144405
SGTC_826 1683-5028 118 µM -0.137878524373997 0.459035271440729 no 1830 0.445168211676323 2722 722377
SGTC_3222 9128301 49.47 µM -0.138217324769318 0.45889906358043 no 1831 0.445034331662852 2688 4911358
SGTC_477 mead ethanolamide 10 µM -0.139680532188946 0.458310866191439 no 1832 0.444456204329206 2632 16061185
SGTC_1108 betulinic acid 729.144 nM -0.140552659846643 0.457960321355078 no 1833 0.44411167441681 2676 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3172 9105863 49.47 µM -0.14233048518273 0.457245840029953 no 1834 0.443409483973785 2691 2348785
SGTC_1432 4049-0298 68.4 µM -0.144858085116113 0.456230273952974 no 1835 0.442411460262067 2752 741646
SGTC_2820 7989630 71.43 µM -0.14493954427928 0.456197549140438 no 1836 0.442379302126707 2677 2984098
SGTC_754 3474-0146 171 µM -0.145522747559891 0.455963265982233 no 1837 0.442149078479434 2649 24762078
SGTC_156 3474-0145 5.642 µM -0.146436557041683 0.455596203237358 no 1838 0.441788385000583 2620 2265471
SGTC_3127 9126946 49.47 µM -0.146864770935481 0.455424209544419 no 1839 0.441619379531927 2765 27243249
SGTC_2872 9044037 25.97 µM -0.148396098467375 0.454809214763644 no 1840 0.441015089477831 2648 6465195
SGTC_760 0568-0725 82.9 µM -0.148475378174542 0.454777378262873 no 1841 0.440983807971256 2824 3916171
SGTC_1113 artemisinin 1.17947 µM -0.148578333652358 0.454736034672043 no 1842 0.44094318523186 2689 2240 An anti-malaria and mitochondrial poison.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.148789319350975 0.454651311170177 no 1843 0.440859939373603 2791 521171
SGTC_442 cape 100 µM -0.149376031484017 0.454415721667243 no 1844 0.440628461815732 2734 5281787
SGTC_2122 5258151 111.688 µM -0.149485196563483 0.454371889081014 no 1845 0.44058539477712 2709 2173356
SGTC_2016 5121758 140 µM -0.149761139836665 0.454261093240527 no 1846 0.440476534714297 2646 2795203
SGTC_2113 5491891 107.031 µM -0.15002601011888 0.454154746738633 no 1847 0.440372047195482 2685 789979
SGTC_2000 st075254 36.4 µM -0.150636088291562 0.453909810372075 no 1848 0.440131395933364 2686 17234175
SGTC_1366 1683-0113 21.9 µM -0.150837951144324 0.453828769606947 no 1849 0.440051774034954 2672 708623
SGTC_3328 9140624 29.0385 µM -0.151593006050629 0.453525658952295 no 1850 0.439753975007854 2836 4904392
SGTC_1557 sumaresinolic acid 42.3 µM -0.151919715330197 0.45339451254835 no 1851 0.439625129098648 2669 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1205 4161-2785 76 µM -0.152725151933036 0.453071218971713 no 1852 0.439307512537507 2836 3498106
SGTC_3137 9097352 49.47 µM -0.152999507119753 0.452961102845921 no 1853 0.43919933198793 2969 44120435
SGTC_410 α-linolenic acid 100 µM -0.153318324455553 0.452833145786099 no 1854 0.439073625345257 2795 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1174 0739-0097 51.1 µM -0.154574659144661 0.452328964756171 no 1855 0.43857832446086 2733 728447
SGTC_1870 st057514 26.5 µM -0.156563770955361 0.451530869645103 no 1856 0.437794328469406 2659 5393161
SGTC_3226 9131256 49.47 µM -0.157647733359179 0.451096031594583 no 1857 0.437367194030478 2671 17178073
SGTC_2256 7954252 200 µM -0.158401342187851 0.450793751420513 no 1858 0.437070278109321 2760 2972920
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.16100930733526 0.449747891400528 no 1859 0.436043035046605 2884 94937 An inhibitor of serotonin biosynthesis.
SGTC_2930 9013230 14.89 µM -0.164035490922691 0.448534753048742 no 1860 0.434851602249881 2809 2995857
SGTC_1893 st059353 36.1 µM -0.164266077540243 0.448442334924732 no 1861 0.43476084255504 2742 3112488
SGTC_1160 4092-0570 10.5 µM -0.164307247422677 0.448425834507252 no 1862 0.434744638307639 2687 4994975
SGTC_3353 9151644 39.2805 µM -0.164430794505927 0.448376318786633 no 1863 0.43469601148898 2812 4909158
SGTC_1793 st048256 72.231 µM -0.164552794273812 0.44832742399477 no 1864 0.43464799464656 2666 672022
SGTC_1384 3089-0840 101 µM -0.165317121712274 0.448021116460393 no 1865 0.434347191529479 2766 1069836
SGTC_1504 k297-0033 30 µM -0.166337935412426 0.447612069309949 no 1866 0.433945506861237 2658 4388117
SGTC_2354 9060492 162 µM -0.167109867338027 0.447302787785386 no 1867 0.433641801088506 2837 6471895
SGTC_1879 gemcitabine 100 µM -0.167322865281549 0.447217453860627 no 1868 0.43355800692818 2713 60750 A nucleoside analog which inhibits DNA replication.
SGTC_102 gallobenzophenone 83.616 µM -0.169248072167386 0.446446264503024 no 1869 0.432800759516877 2852 70837
SGTC_1235 benzylparaben 21.5 µM -0.16929170523838 0.44642878853034 no 1870 0.432783600038586 2794 7180
SGTC_896 0964-0007 44.5 µM -0.170526782822973 0.445934156979962 no 1871 0.432297936586749 2668 6756758
SGTC_2255 7941087 197.44 µM -0.172904591279346 0.444982115018861 no 1872 0.431363211346531 2852 935561
SGTC_1874 staurosporine 7.6 µM -0.174692024228518 0.444266659905996 no 1873 0.430660817575108 2835 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3260 9137109 49.47 µM -0.175576115118669 0.44391285214771 no 1874 0.430313484101221 2814 17478346
SGTC_694 1315-0438 43.2 µM -0.176450586436724 0.443562938052752 no 1875 0.429969982909189 2758 6793154
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.176889669998748 0.44338725815463 no 1876 0.429797526408774 2691 5355888
SGTC_764 1951-2361 146 µM -0.177290393673631 0.443226935981906 no 1877 0.429640148005035 2742 5438930
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.177522560021 0.443134054746369 no 1878 0.429548973157464 2787 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_225 nsc-122657 1.016 µM -0.177827866349808 0.443011917645331 no 1879 0.429429080975932 2830 275685
SGTC_200 k038-0079 37.545 µM -0.177936151267384 0.442968599811089 no 1880 0.42938655962431 2752 3436683
SGTC_1200 1643-0193 18.4 µM -0.179594227010369 0.442305395734915 no 1881 0.428735568585088 2707 5403974
SGTC_1245 0418-0076 17.2 µM -0.179653283588869 0.44228177700807 no 1882 0.428712385450383 2905 6790114
SGTC_1673 st016611 27.3 µM -0.18023692649753 0.442048369478569 no 1883 0.428483284973574 2939 5226799
SGTC_1213 1315-0166 115 µM -0.180556715591152 0.44192048956287 no 1884 0.428357766662585 2848 768401
SGTC_2276 7947513 42.08 µM -0.181309633950489 0.441619430248757 no 1885 0.428062272276552 2812 2105100
SGTC_2311 7694451 200 µM -0.18197671087064 0.44135272336451 no 1886 0.427800501377622 2809 2163142
SGTC_2369 9071472 200 µM -0.182057175970252 0.441320554062869 no 1887 0.42776892782184 2871 17296037
SGTC_803 4488-1585 147 µM -0.182886967087564 0.440988832846196 no 1888 0.427443354591664 2855 747204
SGTC_169 k015-0017 16.025 µM -0.183183137836 0.440870444241893 no 1889 0.427327162278683 2860 1840002
SGTC_1124 fisetin 1.16336 µM -0.183430767640991 0.440771463009086 no 1890 0.4272300181582 2801 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2539 epi(13)torulosol 80 µM -0.183578575621647 0.440712383773635 no 1891 0.427172035817874 2825 6708597
SGTC_2950 9072895 21.46 µM -0.183642252936524 0.440686932191398 no 1892 0.427147056868397 2836 17332245
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.184940964160974 0.440167895824738 no 1893 0.426637670202387 2728 229346 A bile salt which induces apoptosis.
SGTC_473 2-arachidonoylglycerol 10 µM -0.189001315711222 0.438545823352547 no 1894 0.425045892793855 2711 5282280 An endocannabinoid.
SGTC_2946 9065502 71.43 µM -0.189210961704509 0.438462099516542 no 1895 0.424963738323402 2724 16489101
SGTC_3215 9129942 49.47 µM -0.190101265534707 0.438106580150579 no 1896 0.424614889205793 2831 17682944
SGTC_1039 k821-0043 94 µM -0.191021547357234 0.437739142365308 no 1897 0.424254355820787 2906 15992768
SGTC_1325 1431-0015 227 µM -0.191462460283227 0.437563119565487 no 1898 0.424081644399577 2740 1103340
SGTC_3165 9101544 49.47 µM -0.1920955764225 0.437310386344831 no 1899 0.423833669945167 2850 5002184
SGTC_2101 5377231 179.231 µM -0.192109375591931 0.437304878147792 no 1900 0.423828265519476 2869 2844213
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.19305965472898 0.436925585714123 no 1901 0.423456124523936 2795 676296 Flavone; oxidizing agent.
SGTC_765 1319-0117 244 µM -0.194038956683419 0.436534769831021 no 1902 0.423072689265876 2746 3487746 YGL099W LSG1
SGTC_445 e6 berbamine 66 µM -0.194365283373822 0.436404554429108 no 1903 0.422944935688939 2847 6610268 A calcium/calmodulin antagonist.
SGTC_749 1000-0129 128 µM -0.194763141544643 0.436245804868413 no 1904 0.422789189228559 2909 708470
SGTC_3344 9148862 3.898 µM -0.195342784741308 0.436014539572256 no 1905 0.422562302395546 2899 4905352
SGTC_962 1254-0300 21.5 µM -0.195766351676618 0.43584555921034 no 1906 0.422396523952022 2746 7340576
SGTC_140 0062-0056 502.533 µM -0.195847287535721 0.43581327149963 no 1907 0.42236484830068 2714 3758964
SGTC_2682 pyrogallin 40.03 µM -0.195977541832654 0.435761310102102 no 1908 0.422313872078156 2792 822798 An ATP competetive kinase inhibitor.
SGTC_1866 st057638 64 µM -0.196011431046807 0.435747791106601 no 1909 0.422300609434381 2768 688802
SGTC_2994 9053520 71.4286 µM -0.196296255630815 0.435634172607104 no 1910 0.422189145977692 2890 4647384
SGTC_2337 9009472 200 µM -0.196734860505213 0.435459220477362 no 1911 0.422017514222025 2913 5742383
SGTC_1813 st051246 8.6015 µM -0.197561183158454 0.435129648570258 no 1912 0.421694203746266 2808 5291959
SGTC_2821 7996764 71.43 µM -0.197613717530912 0.435108697194454 no 1913 0.421673650708868 2963 2987135
SGTC_105 0111-0055 734.78 µM -0.197650105345781 0.435094185377944 no 1914 0.421659414818839 2832 5179370
SGTC_1779 st039427 55 µM -0.198050428599662 0.434934538324208 no 1915 0.421502804378252 2775 1124498
SGTC_54 0159-0055 9 µM -0.198107249355931 0.434911879329611 no 1916 0.421480576538642 2985 3319099
SGTC_3188 9110789 49.47 µM -0.199123005199775 0.434506852110369 no 1917 0.421083263003843 2920 849217
SGTC_430 0958-0115 16.4 µM -0.199710212725107 0.434272737568912 no 1918 0.420853613039874 2790 6833180
SGTC_1914 st062367 72.6 µM -0.200026546457562 0.434146627604623 no 1919 0.420729909790175 2783 978205
SGTC_713 1488-1073 324 µM -0.200626095059783 0.4339076292777 no 1920 0.420495476006068 2752 3312542
SGTC_2761 levamisole 97.89 µM -0.200707465521867 0.433875194394162 no 1921 0.420463660931462 2890 26879 An alkaline phosphatase inhibitor.
SGTC_3211 9128781 49.47 µM -0.201859654139986 0.433415971157038 no 1922 0.420013222033226 2894 17194361
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.202856890308551 0.433018579239013 no 1923 0.419623445098598 2899 61125 An anti-inflammatory.
SGTC_573 3702-0553 84.7 µM -0.203321297772488 0.432833539071157 no 1924 0.419441954983486 2780 1222756
SGTC_2933 9026794 32.47 µM -0.204682964384961 0.432291076805675 no 1925 0.418909915535554 2822 17586027
SGTC_2281 7943571 200 µM -0.205901327156811 0.431805812225079 no 1926 0.418433994370368 2921 1244024
SGTC_2294 7971431 200 µM -0.206321798184522 0.431638365671051 no 1927 0.418269776167459 2908 5741572
SGTC_921 1561-0023 372 µM -0.20759529603297 0.43113128848313 no 1928 0.417772488788165 2743 24050882
SGTC_222 nsc-310342 10.666 µM -0.208207723275618 0.430887474578493 no 1929 0.417533389217021 2755 432556
SGTC_2840 9008771 71.43 µM -0.209502009773066 0.430372291893439 no 1930 0.417028183312713 2936 2992978
SGTC_3071 9117417 49.47 µM -0.210281408810296 0.430062114063812 no 1931 0.416724022261328 2857 45595590 YGL055W OLE1
SGTC_1646 st011709 75.6 µM -0.210463683874891 0.429989580183637 no 1932 0.416652896467642 2838 5757843
SGTC_3142 9086498 49.47 µM -0.210719304582145 0.42988786338428 no 1933 0.416553154970645 2918 25236367
SGTC_1677 st019204 53.9 µM -0.21384391569474 0.428644893679541 no 1934 0.415334388608242 2889 3945625
SGTC_472 calcifediol 10 µM -0.21399760484186 0.428583774319429 no 1935 0.415274462489016 2852 5283731 A vitamin D metabolite.
SGTC_1382 3002-2117 298 µM -0.215272748310759 0.428076739298446 no 1936 0.414777337615775 2913 1497314
SGTC_2165 5727197 32.143 µM -0.215311397825627 0.428061372949868 no 1937 0.414762271920075 3204 1361712
SGTC_793 0488-0545 106 µM -0.215847606436912 0.42784819736292 no 1938 0.414553269155395 2774 292548
SGTC_1396 3511-0007 98.6 µM -0.21622599807934 0.427697776304886 no 1939 0.41440579465805 2915 X1396
SGTC_1092 toremifene 6.32 µM -0.216522638047774 0.427579861126832 no 1940 0.414290190524089 2777 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1176 0848-0131 83.3 µM -0.217307790248237 0.427267792279842 no 1941 0.413984243206563 2890 6769040
SGTC_426 0988-0037 14.6 µM -0.219389427011602 0.426440639724509 no 1942 0.413173352723093 2823 5383008
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.22032513149005 0.426068936324743 no 1943 0.412808974457614 2969 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3326 9140064 16.379 µM -0.220738863547624 0.425904604485146 no 1944 0.412647884518118 2780 1868434
SGTC_1663 st014140 55.4 µM -0.223865345483049 0.424663202977096 no 1945 0.411431040840353 2827 4207120
SGTC_1736 st036774 51 µM -0.224999837464092 0.424212925402137 no 1946 0.410989700352992 3080 1272247
SGTC_1739 st037196 92.5 µM -0.22598146400272 0.423823399602806 no 1947 0.410607918514887 2971 612214
SGTC_1297 1068-0111 14.1 µM -0.226005531355495 0.423813850208528 no 1948 0.410598559114738 2793 767057
SGTC_109 0132-0036 33.701 µM -0.226421662504437 0.423648745633959 no 1949 0.410436740566207 2770 67274 A color developer.
SGTC_2179 6298986 200 µM -0.227100491891598 0.423379441445185 no 1950 0.410172800783651 2940 738374
SGTC_190 3970-0790 3.722 µM -0.22803322176804 0.423009468628272 no 1951 0.409810206790299 2840 2832352
SGTC_2697 mebhydrolin 72.4 µM -0.22805610852577 0.423000391312611 no 1952 0.409801310647759 2948 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1664 st014217 9.02 µM -0.229290925758966 0.422510700454152 no 1953 0.409321402912766 2837 3982782
SGTC_1254 0550-0035 264 µM -0.232561444107899 0.421214293095807 no 1954 0.408050984783053 2947 15121435
SGTC_2188 6126565 140.678 µM -0.234872653053301 0.420298662277331 no 1955 0.407153787794104 2922 874518
SGTC_2516 gossypol 71.55 µM -0.236002960572123 0.419851025427465 no 1956 0.406715186427721 2977 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2338 7999974 200 µM -0.2362882985076 0.419738039118268 no 1957 0.406604483166334 2895 315925
SGTC_1921 5740136 50 µM -0.237045694376117 0.419438162409031 no 1958 0.406310670647978 3013 1774243
SGTC_181 1447-1644 8.07 µM -0.23759540892711 0.419220542517873 no 1959 0.40609745585441 2918 534600
SGTC_604 1000-0114 314 µM -0.238832019897487 0.418731085863776 no 1960 0.405617920152392 2988 1572745
SGTC_3298 9116858 71.43 µM -0.239331958310999 0.418533243462575 no 1961 0.405424093100555 2970 2506942
SGTC_503 tyrphostin 8 294 µM -0.239630651131284 0.418415050523767 no 1962 0.405308300402802 2953 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2014 4013930 200 µM -0.241070125646134 0.417845553012572 no 1963 0.404750383162464 2857 64556
SGTC_1405 3909-7894 12 µM -0.241778493703304 0.417565365398916 no 1964 0.404475902060897 2943 7104060
SGTC_1975 st070967 30.8 µM -0.243727412284621 0.416794707293433 no 1965 0.403720970766879 2974 261391
SGTC_1283 0922-0125 16.4 µM -0.243918083838984 0.416719327430267 no 1966 0.403647131620014 2954 3360884
SGTC_1079 idarubicin 2.36 µM -0.245844758215122 0.415957810550144 no 1967 0.402901204022917 2883 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2118 5526350 200 µM -0.245858037200734 0.415952563130401 no 1968 0.402896064178713 2962 743594
SGTC_3062 9077494 49.47 µM -0.246663297746946 0.415634378603479 no 1969 0.402584406572824 2972 16459633
SGTC_2140 5586273 200 µM -0.246760702598122 0.415595894536941 no 1970 0.402546712454221 2823 854421
SGTC_1922 5578187 25 µM -0.247509774338546 0.415299967908916 no 1971 0.402256863977509 3073 1350412
SGTC_1835 st008666 49.2 µM -0.24762896053919 0.415252886897377 no 1972 0.40221075059726 2858 690455
SGTC_428 3448-4153 16.5 µM -0.2485000557877 0.414908823267292 no 1973 0.40187376345933 2784 3834874
SGTC_183 3914-0051 30.55 µM -0.248753729827507 0.414808639810068 no 1974 0.401775642211824 2976 1596232
SGTC_2693 st077581 40.7 µM -0.249021915850366 0.414702731162184 no 1975 0.401671914454937 2954 25238761
SGTC_1629 st005085 44.9 µM -0.249227222147657 0.414621658373348 no 1976 0.401592511710142 2852 24207091
SGTC_3030 9087619 49.47 µM -0.25104842668956 0.413902647966968 no 1977 0.400888334341158 2897 25236973
SGTC_1115 galangin 695.678 nM -0.251309309831612 0.413799675036127 no 1978 0.400787488943517 2924 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1678 st019265 80.2 µM -0.251712509170408 0.41364054027909 no 1979 0.400631643671576 3081 5367020
SGTC_1750 st081859 2.357 µM -0.252556664208391 0.413307415040599 no 1980 0.400305410725043 2886 5291695
SGTC_177 1327-0068 8.361 µM -0.253346434166899 0.41299580804365 no 1981 0.400000258451162 2877 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1018 4259-0013 28.1 µM -0.255566519342825 0.412120158466158 no 1982 0.399142786844172 2994 6801262
SGTC_1873 rapamycin 2 nM -0.256593115590698 0.411715394323171 no 1983 0.39874644503853 2863 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2228 7354201 200 µM -0.257196235521655 0.411477641276036 no 1984 0.398513644953082 2879 753451
SGTC_479 n-linoleoylglycine 10 µM -0.25747814620003 0.41136652174615 no 1985 0.398404841776969 2871 6433346 An anti-infammatory.
SGTC_2176 5809774 33.9695 µM -0.257994903330038 0.411162852258897 no 1986 0.39820542033293 2987 2870539
SGTC_2923 7992654 58.14 µM -0.260151463485363 0.410313146258651 no 1987 0.397373471001348 2897 2985126
SGTC_681 1642-0006 26.6 µM -0.260246226575207 0.410275818289438 no 1988 0.397336924343818 2915 4446530
SGTC_1758 st042942 75.2445 µM -0.262473985110196 0.409398520561518 no 1989 0.396478019672593 2864 669317
SGTC_31 0508-1974 57.237 µM -0.263853587995649 0.408855456078083 no 1990 0.395946369992548 2975 6810525
SGTC_677 0929-0063 136 µM -0.264211619490107 0.408714549729937 no 1991 0.395808429026719 2883 1539583
SGTC_2238 6671620 73.2395 µM -0.265150804268758 0.408344981663282 no 1992 0.395446645658312 2803 729941
SGTC_1316 1272-0050 65.9 µM -0.26635290731782 0.407872074541172 no 1993 0.394983715022055 2874 7340392
SGTC_3039 9090270 49.47 µM -0.266671023106627 0.407746950273715 no 1994 0.394861233205666 2985 17173750
SGTC_499 genistein 192 µM -0.266976957784078 0.40762662607022 no 1995 0.394743451194968 2925 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_333 3486-0131 40.1 µM -0.268308102828675 0.407103187891687 no 1996 0.394231084831475 3040 6744690
SGTC_3214 9129694 49.47 µM -0.268316542055784 0.407099869913203 no 1997 0.394227837100973 3031 17158655
SGTC_1568 digitonin 820 nM -0.268531014777067 0.407015549752569 no 1998 0.394145302438245 3042 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1147 3809-1045 12.3 µM -0.268865451938468 0.406884074055687 no 1999 0.394016611835423 2896 325925
SGTC_2851 9015922 71.43 µM -0.269424094160497 0.406664481095864 no 2000 0.393801673486803 3070 2996893
SGTC_2473 5854593 8.94 µM -0.269753955167574 0.406534831999001 no 2001 0.393674774204824 2844 2872951
SGTC_605 1315-0399 119 µM -0.270291573001368 0.40632354778923 no 2002 0.393467973971538 3010 24020461
SGTC_2409 alverine citrate 63.97 µM -0.271027924961078 0.406034205190852 no 2003 0.393184777385569 3127 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1017 4239-0030 168 µM -0.271184709375805 0.405972604846245 no 2004 0.393124486324285 2890 1149593
SGTC_2837 9008476 45.46 µM -0.271792212646528 0.405733939785684 no 2005 0.392890896656541 3079 2992805
SGTC_3080 9117754 49.47 µM -0.27203005461863 0.405640510208211 no 2006 0.392799455094439 3100 9550191
SGTC_2623 humulene 100 µM -0.272082016474067 0.405620099159512 no 2007 0.392779478443799 2977 6187145 An anti-inflammatory.
SGTC_1139 k015-0024 46.9 µM -0.272283201987859 0.405541074238229 no 2008 0.39270213566498 3007 2766652
SGTC_78 0336-0123 156.75 µM -0.272433811634768 0.405481917848971 no 2009 0.392644238798846 2821 6765896
SGTC_2482 5981709 142.65 µM -0.273079904716105 0.405228170211196 no 2010 0.392395896785788 2932 877755
SGTC_2704 st078022 71.1 µM -0.273444615926921 0.40508495052458 no 2011 0.392255730262562 3049 54697681
SGTC_798 1287-0182 476 µM -0.273704320658146 0.404982973936864 no 2012 0.392155928553715 3072 1649755
SGTC_223 busulfan 5 mM -0.273796875292368 0.404946632662518 no 2013 0.392120362526806 2982 2478 A DNA alkylator.
SGTC_2149 5554786 194.827 µM -0.27466808160045 0.404604596570688 no 2014 0.391785627744485 2892 745063 YPR165W RHO1
SGTC_3182 9108849 49.47 µM -0.274904967968353 0.404511607440192 no 2015 0.391694625132125 2989 17133045
SGTC_3130 9127414 49.47 µM -0.276314143125301 0.403958551024222 no 2016 0.391153396990285 2870 1494646
SGTC_3005 9076496 71.4286 µM -0.2765654193582 0.403859953228991 no 2017 0.391056910321499 2998 21368410
SGTC_1967 st070177 51.4 µM -0.276817670808362 0.403760978914097 no 2018 0.390960055926631 3061 5729214
SGTC_1651 st011928 86.1 µM -0.278231050386073 0.403206534218929 no 2019 0.390417500372711 3007 720198
SGTC_3205 9113483 49.47 µM -0.278278454195057 0.403187941878845 no 2020 0.390399307112692 3082 17018033
SGTC_2560 caryophyllene 100 µM -0.278683361222164 0.403029141429006 no 2021 0.390243916328783 2862 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3002 9075603 71.4286 µM -0.279405755729422 0.402745865327906 no 2022 0.38996672723771 2890 20105405
SGTC_3074 9116018 49.47 µM -0.280803837976059 0.402197773601664 no 2023 0.389430429871017 2864 17027303
SGTC_2290 7904846 200 µM -0.280957676765701 0.402137475732347 no 2024 0.389371430917924 2957 2962154
SGTC_306 1672-3436 11.6 µM -0.281379571727565 0.401972123884805 no 2025 0.389209642415795 3002 6797378
SGTC_3204 9114183 49.47 µM -0.282301032347788 0.401611040022051 no 2026 0.388856347028555 2854 17027248
SGTC_298 1391-0729 10 µM -0.28285095536137 0.401395587006519 no 2027 0.388645545903827 2903 3237558
SGTC_1768 st044301 37.178 µM -0.284015782562762 0.400939321223875 no 2028 0.388199142869892 2952 3931349
SGTC_2325 6158266 200 µM -0.284912518018192 0.400588159655068 no 2029 0.387855582650776 2990 3623240
SGTC_3108 9121785 49.47 µM -0.286068813636866 0.40013547294661 no 2030 0.387412708477029 2828 17140271
SGTC_1425 4048-4433 7.33 µM -0.286153548910085 0.400102304577177 no 2031 0.387380259671713 2980 23734946
SGTC_2603 homopterocarpin 100 µM -0.287080134374974 0.399739653474436 no 2032 0.387025481362483 3037 101795 A weak amylase inhibitor.
SGTC_2610 ononetin 44.17 µM -0.287350563252703 0.399633828115547 no 2033 0.386921955209097 2967 259632
SGTC_668 1682-0499 62.6 µM -0.287695195671702 0.399498975802264 no 2034 0.386790033958786 2956 682214
SGTC_844 0330-0132 15.3 µM -0.288723567210153 0.399096652361444 no 2035 0.386396463187663 3034 2828079
SGTC_2426 5582046 32.21 µM -0.289547066747383 0.398774556970928 no 2036 0.386081383742844 3105 2251934
SGTC_1363 1636-0063 10.4 µM -0.289577619691141 0.398762608122172 no 2037 0.386069695314393 2925 6072185
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.290137101441257 0.398543819061289 no 2038 0.385855676544891 2977 6857784
SGTC_2480 5767542 37.17 µM -0.290404836635804 0.398439130707532 no 2039 0.385753271983308 2952 2867358
SGTC_2529 gangaleoidin 93.61 µM -0.290949121884477 0.398226329800646 no 2040 0.385545115865206 2891 4565183
SGTC_2595 hexamethylquercetagetin 100 µM -0.291194772614883 0.39813029687444 no 2041 0.385451180141574 2994 386331
SGTC_2002 4023503 131 µM -0.291339607394937 0.398073679100489 no 2042 0.385395799127827 3036 4736863 YCR052W RSC6
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.293093404302331 0.39738826805376 no 2043 0.384725379058944 2964 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2906 7926292 26.41 µM -0.293599043077526 0.397190715301352 no 2044 0.38453215354266 3048 2966319
SGTC_171 k064-0041 9.68 µM -0.294836827078331 0.396707225268405 no 2045 0.384059266156681 2947 53325
SGTC_3227 9130768 49.47 µM -0.29658612853575 0.396024202601074 no 2046 0.383391251221442 2922 17720899
SGTC_636 0kpi-0074 126 µM -0.297343498290488 0.395728583012845 no 2047 0.38310213782787 3006 616434
SGTC_2999 9069765 71.4286 µM -0.29850075175359 0.395276995099884 no 2048 0.38266050121898 3012 2097066
SGTC_1523 st012844 44.7 µM -0.300922731690812 0.394332336454821 no 2049 0.381736707941637 3040 4274103
SGTC_1946 st076057 65.1 µM -0.301906475331509 0.393948818386621 no 2050 0.381361679681351 2909 953009
SGTC_454 lyso-paf C-16 6.67 µM -0.303739333587766 0.39323454266215 no 2051 0.380663244484303 3019 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2925 9010536 32.5 µM -0.304404429682536 0.392975439475947 no 2052 0.380409896714488 3000 2994177
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.304704583448905 0.392858523324546 no 2053 0.380295579217619 3124 1273210
SGTC_3035 9091303 49.47 µM -0.305416987789851 0.392581065690583 no 2054 0.38002429255676 2945 25237002
SGTC_3299 9121982 43.1275 µM -0.305513500622066 0.392543481369668 no 2055 0.379987544588651 2964 17594604 YPL160W CDC60
SGTC_6 0844-0013 19.835 µM -0.305708115300018 0.392467696977431 no 2056 0.379913446919558 3021 1584900
SGTC_56 0957-0365 83.25 µM -0.306465837595054 0.392172673189988 no 2057 0.379624993452668 3063 6752360
SGTC_1722 st034304 3.6505 µM -0.30708674042389 0.391930967083545 no 2058 0.379388675016606 2955 4036148 YLR033W RSC58
SGTC_2558 carylophyllene oxide 100 µM -0.307135708362721 0.391911906534135 no 2059 0.379370039512409 2913 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2695 st077686 51.995 µM -0.30903700121598 0.391172037859726 no 2060 0.378646690298524 2999 2876092
SGTC_1006 4099-6547 255 µM -0.309659827739313 0.390929756751488 no 2061 0.378409827454195 3040 3146833
SGTC_1078 idebenone 36.1 µM -0.31129571182661 0.390293595483361 no 2062 0.377787913462201 3022 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_385 1494-0393 12.4 µM -0.312337015951924 0.389888806817551 no 2063 0.377392205734719 2998 3090647
SGTC_2859 9028643 45.46 µM -0.313052525146441 0.389610734375737 no 2064 0.377120378448582 3018 17151580
SGTC_3128 9127691 49.47 µM -0.313202728737548 0.389552367063674 no 2065 0.377063322710082 3082 41316314
SGTC_811 0416-0114 265 µM -0.313476826401547 0.389445862424198 no 2066 0.376959211980871 3051 6612453
SGTC_2245 6637752 200 µM -0.313627837401248 0.389387188447835 no 2067 0.376901857176471 3080 681890
SGTC_2764 methyldopa 94.69 µM -0.316518830342476 0.388264406635761 no 2068 0.375804367376927 3149 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1705 st027868 56.3335 µM -0.316868090317265 0.388128826700667 no 2069 0.375671847765315 3036 292948
SGTC_2708 st078559 56 µM -0.31690190956674 0.388115699061627 no 2070 0.375659016515766 3054 17250902
SGTC_3303 9125618 40.5795 µM -0.317174378544685 0.388009939274803 no 2071 0.375555644980477 3038 22695467
SGTC_935 2996-0153 430 µM -0.318182883037039 0.387618557051067 no 2072 0.375173107979052 3111 23738523
SGTC_2225 6654152 15.4 µM -0.318758492943944 0.387395224481082 no 2073 0.37495482771519 3024 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2641 levomentholum 100 µM -0.319383708600132 0.387152687448137 no 2074 0.374717781550803 3030 16666
SGTC_3272 9137413 49.47 µM -0.319406129351608 0.387143990686754 no 2075 0.374709281757509 2936 17614870
SGTC_2297 7971671 152.32 µM -0.319622056257253 0.387060237930061 no 2076 0.374627426151893 3151 909016
SGTC_817 1391-0715 46 µM -0.322617609692299 0.385898880206129 no 2077 0.373492427845556 3014 1353946
SGTC_1494 4358-1428 177 µM -0.322988694812306 0.385755083703817 no 2078 0.373351901920126 3118 1564571
SGTC_3176 9106582 49.47 µM -0.323319123081149 0.385627055054814 no 2079 0.37322678647955 3043 17018027
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.323541369164736 0.385540949981704 no 2080 0.373142641340348 2989 689007
SGTC_2159 5658611 73.75 µM -0.323805696705306 0.385438548582288 no 2081 0.373042571514146 3089 793844
SGTC_517 1365-0151 113 µM -0.324088106084706 0.38532915104031 no 2082 0.37293566568082 3140 768657
SGTC_2339 9000433 200 µM -0.324132743754574 0.385311860482854 no 2083 0.372918769023657 3024 2988954
SGTC_1333 1482-0047 286 µM -0.324578055170729 0.38513938003608 no 2084 0.372750219081952 3114 3811116
SGTC_2733 amorolfine 100 µM -0.324879189643451 0.385022755864916 no 2085 0.37263625377894 3017 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2026 5148700 152 µM -0.324926401431261 0.385004472499159 no 2086 0.3726183873378 2949 79838
SGTC_666 0272-0154 136 µM -0.325130764337384 0.384925333311667 no 2087 0.372541053079758 3019 6870312
SGTC_928 2764-0428 58.7 µM -0.326802671722215 0.384278070328859 no 2088 0.371908569276781 3081 662578
SGTC_589 1227-0070 34.1 µM -0.327666443418873 0.383943795617001 no 2089 0.371581939056857 3096 2841384
SGTC_2320 7373003 200 µM -0.328176512735749 0.383746442228633 no 2090 0.371389102718542 3045 5415828
SGTC_2065 5221596 34.26 µM -0.328615439542199 0.383576639066633 no 2091 0.37122318828874 3117 788581
SGTC_3163 9099914 49.47 µM -0.329102142319763 0.383388379439527 no 2092 0.37103924251071 3070 16268368
SGTC_3331 9141060 1.957 µM -0.329949439786517 0.383060705274786 no 2093 0.370719082901553 2993 4906567 YPR165W RHO1
SGTC_2271 7849410 118.62 µM -0.330253883958405 0.382942988423675 no 2094 0.370604067547086 3118 972430
SGTC_2648 atorvastatin 78.68 µM -0.331294263191075 0.382540795447718 no 2095 0.370211112093724 3082 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2998 9066762 71.4286 µM -0.332114979777044 0.382223609671068 no 2096 0.369901219641854 3182 4945196
SGTC_557 1315-0110 16.2 µM -0.332943630984123 0.381903437534333 no 2097 0.369588416860907 2977 6833801
SGTC_275 trichlorophene 5.69 µM -0.333221309288255 0.381796166954979 no 2098 0.369483616966717 3082 62616
SGTC_559 1550-0661 158 µM -0.33540590387168 0.380952548115523 no 2099 0.368659457497848 3068 5830875
SGTC_1919 st067113 52.3 µM -0.336091450650888 0.380687928813299 no 2100 0.368400952610598 3134 1268243
SGTC_1630 st005209 31.3 µM -0.337516087784628 0.380138201141207 no 2101 0.367863943306928 3062 3367314
SGTC_1969 st069479 40.1 µM -0.337615862483097 0.380099709929299 no 2102 0.367826343432848 3171 3895485
SGTC_946 3434-1334 87.4 µM -0.340669647645129 0.378922192843372 no 2103 0.366676145461375 3136 4047976
SGTC_1105 epirubicin 18.1 µM -0.341556587682773 0.378580405221098 no 2104 0.366342306162189 2992 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1790 st045711 43.5 µM -0.343648534697863 0.377774637520029 no 2105 0.365555309863095 3172 585119
SGTC_759 3486-0358 89.3 µM -0.348206229622745 0.376020967807122 no 2106 0.36384265481726 3196 875103
SGTC_925 2064-1272 59.6 µM -0.349504940054655 0.375521728001549 no 2107 0.363355131377326 3037 6815817
SGTC_2300 7976697 71.57 µM -0.351159796921892 0.374885883250381 no 2108 0.362734234641305 2997 2236109
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.355086623453945 0.373378444007056 no 2109 0.361262348739266 3216 5393153
SGTC_1101 ebselen 5.29 µM -0.3553214570918 0.373288356643879 no 2110 0.361174391229958 3177 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1899 st063254 59.6 µM -0.355673527903885 0.373153307491607 no 2111 0.361042536003061 2994 3093813
SGTC_1591 genipin 88.4 µM -0.357202547695029 0.37256697912089 no 2112 0.360470089381258 3154 442424 A DNA cross-linking agent.
SGTC_574 1315-0397 40 µM -0.357776414440239 0.372346996371282 no 2113 0.360255321180942 3028 6794277
SGTC_908 3448-7491 47.7 µM -0.358147121579815 0.372204913781961 no 2114 0.360116608393531 3011 1203031
SGTC_839 0122-0028 230 µM -0.358920172045428 0.371908679242799 no 2115 0.359827404316153 3045 759448
SGTC_944 3370-0224 231 µM -0.366126496619606 0.369150869593178 no 2116 0.357135343354729 3074 4580514
SGTC_1674 st016616 23.6 µM -0.368106838338747 0.368394178098295 no 2117 0.356396786049416 3014 625830
SGTC_3095 9117207 49.47 µM -0.369356894205502 0.367916792351371 no 2118 0.355930861672977 3148 17015229
SGTC_1546 5-methoxyflavanone 78.7 µM -0.370944521329398 0.367310785054727 no 2119 0.355339426896974 3128 147795
SGTC_2316 5844804 197.44 µM -0.372030340568876 0.366896511125795 no 2120 0.354935129794737 3159 776813
SGTC_2649 anisomycin 9.56 µM -0.372547183857535 0.366699373685693 no 2121 0.35474274419157 3123 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_885 0865-0106 16.8 µM -0.373361376856374 0.366388890682523 no 2122 0.35443975066749 3048 2793380
SGTC_127 0180-0333 59.125 µM -0.373445693587311 0.366356742473394 no 2123 0.354408378325363 3101 771601
SGTC_486 niguldipine 82 µM -0.373594466783181 0.366300020647343 no 2124 0.3543530256047 3061 1236 A calcium channel blocker.
SGTC_660 4031-1742 102 µM -0.374152634641772 0.366087237524675 no 2125 0.354145380482636 3084 6738706
SGTC_2844 9010103 25.97 µM -0.374789054896808 0.365844673494006 no 2126 0.35390867744044 3213 2480525
SGTC_1437 4092-1038 11.6 µM -0.376258034523355 0.365284994198072 no 2127 0.353362537234401 3064 3977136
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.376630007092071 0.365143318597918 no 2128 0.353224292365789 3161 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_547 1120-0019 610 nM -0.37684666783418 0.365060806099479 no 2129 0.35314377858921 3046 3676939
SGTC_2563 tomatine 8.54 µM -0.377005946287679 0.365000150903091 no 2130 0.353084592963954 3284 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1556 plumbagin 1.48 µM -0.378778592057792 0.364325333870522 no 2131 0.352426142978624 3130 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1169 aniline yellow 25.8 µM -0.379103461426559 0.364201706970841 no 2132 0.352305517989266 3085 6051 A DNA damaging agent.
SGTC_787 4152-0075 138 µM -0.37922545462892 0.364155286908968 no 2133 0.352260225376392 3105 9566539
SGTC_2520 obtusaquinone 4.71 µM -0.379341232727007 0.364111233621417 no 2134 0.352217242193207 3232 5967872
SGTC_1696 st025591 34.7925 µM -0.381370235328605 0.363339494950944 no 2135 0.351464271957125 3077 2787147
SGTC_2005 4024620 188 µM -0.386867464896743 0.361251396822023 no 2136 0.349427164276158 3071 236743
SGTC_211 3455-0679 143.504 µM -0.386922796828065 0.361230400111872 no 2137 0.349406681840794 3174 748649
SGTC_1496 4469-0713 57.4 µM -0.389538453329982 0.360238319541887 no 2138 0.34843893539876 3202 746691
SGTC_3017 9080681 49.47 µM -0.390094228607061 0.360027642952761 no 2139 0.348233435179546 3163 16451914
SGTC_1434 4073-0095 163 µM -0.392615333519945 0.359072507531344 no 2140 0.347301806332955 3184 24133745
SGTC_686 1319-0111 510 µM -0.394409657060532 0.35839325330193 no 2141 0.346639307574568 3246 4562600
SGTC_1144 3486-0183 12.5 µM -0.395800577237824 0.357867018336166 no 2142 0.346126075475788 3119 6744069
SGTC_868 0527-0199 213 µM -0.396133364058551 0.357741153141663 no 2143 0.346003323157964 3127 2849450
SGTC_2484 5809818 12.04 µM -0.396463274887358 0.357616390959231 no 2144 0.345881647655391 3115 2870548
SGTC_1377 2944-0135 198 µM -0.397007625114555 0.357410567620909 no 2145 0.345680918846522 3147 1894137
SGTC_2898 9056270 58.44 µM -0.397399322397377 0.357262489281184 no 2146 0.345536507548378 3168 19154699
SGTC_2326 6164455 177.58 µM -0.397846780049177 0.357093357436189 no 2147 0.345371565974295 3156 2888790
SGTC_1838 st055369 84.5 µM -0.398160522118218 0.35697478468926 no 2148 0.345255932067758 3130 676036
SGTC_2914 7968218 45.32 µM -0.398169490552638 0.356971395445967 no 2149 0.345252626841579 3176 2977111
SGTC_2718 lomofungin 53.02 µM -0.398575352644044 0.356818028724729 no 2150 0.345103062811881 3243 5351222 A RNA synthesis inhibitor.
SGTC_449 xestospongin c 11.1929 µM -0.399384828949952 0.356512213830626 no 2151 0.344804835379875 3193 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1295 1013-0063 9.78 µM -0.400120917153122 0.356234204544841 no 2152 0.344533729289714 3238 6826038
SGTC_1452 4194-0072 190 µM -0.400785914457239 0.355983110888446 no 2153 0.344288875080523 3244 1343545
SGTC_1851 st056236 18.9 µM -0.402048194161542 0.355506663632345 no 2154 0.343824279067097 3276 5393171
SGTC_2636 apigenin dimethyl ether 100 µM -0.402465475831525 0.355349210340185 no 2155 0.343670745742561 3254 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2282 7944268 200 µM -0.403647671047417 0.354903265614737 no 2156 0.343235912564456 3311 2970414
SGTC_1908 st060353 56.5 µM -0.404310919619033 0.354653163621439 no 2157 0.342992048329742 3314 4227716
SGTC_1080 nisoldipine 24.4 µM -0.40481723555542 0.354462280941671 no 2158 0.342805929327509 3043 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3088 9117578 49.47 µM -0.405779952712274 0.354099434433698 no 2159 0.342452144952452 3220 678341
SGTC_158 k038-0087 26.446 µM -0.408196374789797 0.353189272961009 no 2160 0.341564754725427 3067 X158
SGTC_1503 4585-0012 61.3 µM -0.408340293835237 0.353135091320861 no 2161 0.341511930446842 3275 2922052
SGTC_3164 9100705 49.47 µM -0.408428134841211 0.353102023013585 no 2162 0.341479690667825 3250 17174235
SGTC_1133 3473-0247 50 µM -0.408806216865341 0.352959704288278 no 2163 0.341340938603467 3139 711311
SGTC_299 1273-0059 1.44 µM -0.410528636770486 0.352311606586118 no 2164 0.340709100518756 3219 2848077
SGTC_2719 novobiocin 32.65 µM -0.410648819672031 0.352266401148695 no 2165 0.340665030280887 3240 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1980 st071811 45.7 µM -0.410819719834635 0.35220212258218 no 2166 0.340602366120021 3271 4974850
SGTC_1362 1611-0397 101 µM -0.411691147523353 0.351874428939639 no 2167 0.34028290716068 3133 27816
SGTC_752 1896-0090 130 µM -0.412633412398923 0.351520221295994 no 2168 0.339937608756485 3133 772567
SGTC_2174 5790901 200 µM -0.413488921417606 0.351198737743506 no 2169 0.339624218790435 3203 786020
SGTC_1022 4477-0945 21.3 µM -0.413651392003558 0.351137696496602 no 2170 0.339564715101801 3129 4648966
SGTC_3150 9097574 49.47 µM -0.417696340316803 0.349619224993541 no 2171 0.338084574190114 3276 17217476
SGTC_2620 irigenin 100 µM -0.418083971488667 0.349473834241922 no 2172 0.337942861787523 3300 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_257 daunorubicin 18.5 µM -0.41838453639248 0.349361115065293 no 2173 0.337832995370752 3236 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.420400235319118 0.348605522463183 no 2174 0.337096548116395 3089 23665772 A membrane-active detergent.
SGTC_709 3807-1509 243 µM -0.421489273645374 0.348197541735793 no 2175 0.336698921068936 3208 1886677 YPL242C IQG1
SGTC_1508 1080-0625 72.9 µM -0.422243486224318 0.347915097915996 no 2176 0.336423651714421 3180 767111
SGTC_496 calpeptin 138 µM -0.422642973825129 0.347765528632943 no 2177 0.336277883899365 3192 73364 A calpain inhibitor.
SGTC_3290 9121031 71.43 µM -0.423408077991891 0.347479137625452 no 2178 0.335998776084818 3176 17014854
SGTC_2739 tacrine 100.86 µM -0.423777092129041 0.347341040699899 no 2179 0.335864193088941 3251 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1047 2043-3044 82 µM -0.424981019813696 0.346890633327144 no 2180 0.335425255521665 3167 669592
SGTC_1385 3091-4834 14.1 µM -0.426297830145755 0.346398242498517 no 2181 0.334945419404122 3247 4072814
SGTC_3323 9138564 53.9225 µM -0.426692509154182 0.346250711893411 no 2182 0.334801653660539 3298 43912313 YNL103W MET4
SGTC_3341 9147222 25.867 µM -0.42794212307292 0.345783761444454 no 2183 0.334346629149979 3278 1939759
SGTC_2301 7769476 200 µM -0.428214427397749 0.345682039006656 no 2184 0.334247506671528 3205 977820
SGTC_3064 1327-0027 10 µM -0.428226948771819 0.345677361770052 no 2185 0.334242948998932 3160 16000455 YPR107C YTH1
SGTC_1225 1216-0074 20.6 µM -0.428744906256992 0.345483904474722 no 2186 0.334054438344672 3167 4241466
SGTC_1631 benzylvanillin 81.9 µM -0.429231430756169 0.345302224162968 no 2187 0.333877405851536 3276 75506
SGTC_300 r073-0011 5.04 µM -0.429824758409195 0.345080709144181 no 2188 0.333661560746562 3264 2735780
SGTC_2798 7813637 45.45 µM -0.42991217704709 0.345048076448755 no 2189 0.333629763600957 3278 956368
SGTC_2460 5552655 174.22 µM -0.431681247581528 0.34438794413227 no 2190 0.332986549254274 3274 5401989
SGTC_3167 9103034 49.47 µM -0.432122297162749 0.344223439272172 no 2191 0.332826264942341 3237 5127859
SGTC_923 1900-2434 73.3 µM -0.432354572307808 0.344136815981896 no 2192 0.332741864801378 3134 5910570
SGTC_2215 7188065 200 µM -0.432691897786764 0.344011030417178 no 2193 0.332619308372761 3282 940217
SGTC_761 k216-0224 480 µM -0.43329173060908 0.343787400922631 no 2194 0.332401422482636 3328 1340404
SGTC_219 mitoxanthrone 164.414 µM -0.433790604646606 0.343601452471792 no 2195 0.33222025242766 3185 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_74 000s-0487 160.283 µM -0.434255061451328 0.343428366583422 no 2196 0.332051616501074 3255 677548
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.434441023795077 0.34335907449141 no 2197 0.331984106445732 3282 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3001 9076041 71.4286 µM -0.435053802619423 0.343130782057586 no 2198 0.331761687474794 3164 16004211
SGTC_1221 2958-7315 257 µM -0.436249278238837 0.342685569165491 no 2199 0.331327939058843 3250 4562705
SGTC_2784 7567673 72.73 µM -0.439862837505999 0.341341156055542 no 2200 0.330018226482974 3260 3471247
SGTC_63 0099-0242 26.702 µM -0.441918747984538 0.340577157553952 no 2201 0.329274001739774 3285 3898502 YLR359W ADE13
SGTC_1498 4478-3555 97.6 µM -0.444215527366685 0.339724422603945 no 2202 0.328443383577098 3252 3437919
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.444299146615368 0.339693392371432 no 2203 0.328413159075192 3185 4174840
SGTC_2151 5563267 85.4165 µM -0.444632203986511 0.339569809032213 no 2204 0.32829278534086 3207 5310824
SGTC_979 1426-2828 121 µM -0.444885937131097 0.33947567109346 no 2205 0.328201092963305 3317 747872
SGTC_1201 1889-3372 45.9 µM -0.446268106171724 0.338963046358599 no 2206 0.327701795880623 3163 5392199
SGTC_3208 9114115 49.47 µM -0.44677778066249 0.338774091279741 no 2207 0.327517757862375 3242 650895
SGTC_910 3454-3003 490 µM -0.448751367004572 0.338042793276585 no 2208 0.326805512526346 3317 820824
SGTC_856 0433-0016 11.3 µM -0.448767746023904 0.338036726702288 no 2209 0.326799604155672 3268 3911780
SGTC_2689 tacrolimus 100 µM -0.449203206114031 0.337875453415372 no 2210 0.326642537443683 3251 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_569 4130-2812 160 µM -0.449268864403077 0.337851139352068 no 2211 0.326618857727773 3237 743552
SGTC_563 tetrahydrosecaminediol 614 µM -0.44938973291941 0.337806382039064 no 2212 0.326575268224538 3327 334274 A psychoactive constituent of the cannabis plant.
SGTC_1260 0700-1617 7.75 µM -0.449534055493533 0.337752942750502 no 2213 0.326523223451852 3283 2853078
SGTC_1034 k072-0165 12.7 µM -0.450814272330552 0.337279051559534 no 2214 0.326061706968641 3328 5835461
SGTC_1438 4092-1045 4 µM -0.451424956781003 0.337053088534001 no 2215 0.325841649797996 3212 1351342
SGTC_2759 disulfiram 3.38 µM -0.451943626385344 0.336861218635184 no 2216 0.325654797362903 3155 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1315 1237-0019 3.69 µM -0.452597233052277 0.336619492322696 no 2217 0.32541939577846 3314 825140
SGTC_536 3852-0578 10.6 µM -0.453581539076458 0.336255589348439 no 2218 0.325065021624268 3331 2869208
SGTC_345 1362-0200 395 µM -0.453829936545914 0.336163779755378 no 2219 0.324975617467345 3210 1419823
SGTC_376 3970-0862 59.1 µM -0.454347795133692 0.335972406711151 no 2220 0.324789260257066 3297 3135186
SGTC_2158 5657123 3.6195 µM -0.454999688365902 0.335731562026016 no 2221 0.324554731516537 3273 2858827
SGTC_2447 5741742 33.78 µM -0.456588208886039 0.335144959097222 no 2222 0.323983527928117 3298 1776504
SGTC_1729 st035615 45.989 µM -0.459238011460103 0.334167344613067 no 2223 0.323031628446007 3273 17385451
SGTC_1695 st026914 34.495 µM -0.459308673836884 0.334141289891406 no 2224 0.323006259933416 3195 3289191
SGTC_2350 9023895 38.85 µM -0.459666693687793 0.33400929264107 no 2225 0.322877739818147 3326 2997209
SGTC_1455 4262-0120 131 µM -0.461095719905278 0.333482633976123 no 2226 0.322364966180083 3379 1529587
SGTC_2466 5983409 37.09 µM -0.461442972765366 0.333354705610691 no 2227 0.322240413348507 3243 2879657
SGTC_2734 clemastine 41.6 µM -0.4626478539226 0.332910976335246 no 2228 0.321808400792098 3242 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3354 9151612 71.43 µM -0.464011465300368 0.332409072610327 no 2229 0.321319765638732 3326 27261949
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.465591645039475 0.331827832394628 no 2230 0.320753912246194 3198 2724 A muscle relaxant with antifungal properties.
SGTC_1350 1495-0454 146 µM -0.465975039930015 0.331686868528871 no 2231 0.32061668340517 3346 1069057
SGTC_620 0109-0052 432 µM -0.466574070089384 0.331466669153474 no 2232 0.320402321137975 3357 493037
SGTC_1555 citronellol 128 µM -0.46684773266847 0.331366092044073 no 2233 0.320304411223491 3286 8842 A terpine precursor.
SGTC_2062 5245942 200 µM -0.469138881651211 0.330524521340081 no 2234 0.319485184284619 3319 1376160
SGTC_810 3825-7150 143 µM -0.469299264093123 0.330465642669272 no 2235 0.319427870599853 3378 22330411 YGL099W LSG1
SGTC_3198 9112019 49.47 µM -0.47036407292349 0.330074842703742 no 2236 0.319047463843519 3282 45595555
SGTC_2608 thymoquinone 42.66 µM -0.471784217759714 0.329553917854818 no 2237 0.318540408519019 3317 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_167 3672-0051 66.205 µM -0.471950713758117 0.329492866909251 no 2238 0.318480984215741 3203 3237971
SGTC_95 0471-0001 561.058 µM -0.472040096158434 0.32946009394176 no 2239 0.318449084553115 3246 4015405
SGTC_2912 7964298 10.93 µM -0.473144313990642 0.329055329345015 no 2240 0.318055111603814 3316 2975850
SGTC_1267 0828-0272 9.49 µM -0.47362504382892 0.328879174491161 no 2241 0.317883656683329 3387 745334
SGTC_1565 sinapyl alcohol 95.1 µM -0.473897665482055 0.328779294045244 no 2242 0.317786442025402 3307 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1609 st001574 46.4 µM -0.474103457098816 0.328703906230908 no 2243 0.317713066731247 3224 3960012
SGTC_1375 2910-0797 186 µM -0.474891872079802 0.328415150042916 no 2244 0.31743202251596 3239 742508
SGTC_2214 7179297 48.276 µM -0.475706990630288 0.328116721420276 no 2245 0.317141569963014 3287 769744
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.476555701816894 0.327806110519508 no 2246 0.31683926695205 3310 165521
SGTC_2486 5283202 22.39 µM -0.476579490454556 0.327797406080511 no 2247 0.316830795421563 3246 1377751
SGTC_1833 st055984 71 µM -0.476752107764596 0.327734246929113 no 2248 0.316769326396688 3245 676288
SGTC_420 mitomycin C 81.9 mM -0.477322314140164 0.327525648479024 no 2249 0.31656631186448 3223 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2195 6536160 144.242 µM -0.478194196872392 0.327206791944749 no 2250 0.316255996246992 3218 3834386
SGTC_1579 chlormadinone acetate 49.4 µM -0.47872867967601 0.327011388362966 no 2251 0.316065830063322 3346 45114258 A steroidal progestin.
SGTC_608 k048-0125 159 µM -0.479317347589872 0.326796229913904 no 2252 0.315856441403154 3354 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2216 7189485 200 µM -0.47987403600794 0.326592812958125 no 2253 0.315658482166619 3327 731273
SGTC_1831 st055328 12 µM -0.480276549366977 0.326445764506713 no 2254 0.315515380747321 3348 1103068
SGTC_2882 9058044 58.44 µM -0.48039369130519 0.326402974617992 no 2255 0.315473739679019 3301 18076804
SGTC_2812 7970281 58.44 µM -0.482343472387491 0.325691089722049 no 2256 0.314780985047742 3369 2233435
SGTC_399 oxolinic acid 75 µM -0.483575841864507 0.325241466526044 no 2257 0.314343461554858 3243 4628 A DNA gyrase inhibitor.
SGTC_2707 st078556 66.6 µM -0.484110276608045 0.325046559974978 no 2258 0.314153804201838 3282 17250899
SGTC_2077 5212015 200 µM -0.485290059322788 0.32461646671968 no 2259 0.31373530296034 3247 780900
SGTC_611 3453-1652 23.7 µM -0.485563953082869 0.324516651358874 no 2260 0.31363817958612 3377 1560575
SGTC_693 4161-2696 114 µM -0.486116689214298 0.324315255600689 no 2261 0.313442217387287 3335 805759
SGTC_2184 6075246 200 µM -0.487411071882117 0.323843833546066 no 2262 0.312983524437311 3310 2267320
SGTC_25 0118-0223 35.662 µM -0.488567191480248 0.323423006501691 no 2263 0.312574072621477 3393 5333628
SGTC_2939 9044578 71.43 µM -0.488830233505296 0.323327290825652 no 2264 0.312480945816458 3247 2653634
SGTC_145 3737-0113 38.366 µM -0.489545370915892 0.323067125897194 no 2265 0.312227820723639 3372 6849351
SGTC_1755 st041960 45.185 µM -0.489931055834396 0.322926850746171 no 2266 0.312091343128075 3368 2257073
SGTC_2333 9017922 200 µM -0.490461455704437 0.322733983323112 no 2267 0.311903699143742 3361 3163164
SGTC_495 decylubiquinone 155 µM -0.491366333607906 0.322405055850687 no 2268 0.31158368562652 3315 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1997 st073024 93.8 µM -0.491584761565097 0.322325677051422 no 2269 0.311506459053868 3358 686268
SGTC_2626 ethyl orsellinate 100 µM -0.491675366201233 0.322292752840936 no 2270 0.311474427650081 3239 75653 A natural product.
SGTC_834 0312-0008 75.7 µM -0.492214078908237 0.322097022440582 no 2271 0.311284006334002 3331 6385573 YIL048W NEO1
SGTC_1787 fluconazole 80 µM -0.492338587702629 0.322051791697013 no 2272 0.311240002805531 3343 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2066 5222451 176 µM -0.493140859924211 0.321760410702019 no 2273 0.310956530846748 3278 2281147
SGTC_111 0083-0039 52.457 µM -0.493685066833688 0.321562820020264 no 2274 0.310764306568903 3286 759313
SGTC_346 4513-0042 7.16 µM -0.497566585913025 0.320154984293112 no 2275 0.3093947800059 3284 2827372
SGTC_1089 terbinafine 2.25 µM -0.498406177366354 0.319850801972236 no 2276 0.309098891819297 3374 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2756 carbadox 75.1 µM -0.498530513676141 0.319805765463631 no 2277 0.309055083830623 3293 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_700 3453-2283 142 µM -0.501296700444559 0.31880449834798 no 2278 0.308081163549633 3419 565664
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.504967290605334 0.317477907726573 no 2279 0.30679090503021 3309 688669
SGTC_2973 9094665 17.96 µM -0.505027456620156 0.317456182537673 no 2280 0.306769775788415 3428 25237061 YIL048W NEO1
SGTC_1658 st012944 20 µM -0.507243116136982 0.316656574287907 no 2281 0.305992122920812 3350 24207260
SGTC_2918 7977171 22.06 µM -0.507591766920614 0.316530827732712 no 2282 0.305869832827733 3325 2236483
SGTC_2453 5731132 22.18 µM -0.50765761816986 0.316507079792743 no 2283 0.305846737774438 3405 1362040
SGTC_2019 4016004 108 µM -0.508966056267011 0.316035374635399 no 2284 0.30538800843369 3328 45595336
SGTC_533 1222-0222 6.71 µM -0.510836119081046 0.31536171782581 no 2285 0.304732907645407 3433 3982874
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.511916121687357 0.314972945359036 no 2286 0.304354857292302 3330 442882
SGTC_1552 6-methylflavone 10.6 µM -0.511969258297126 0.314953822865832 no 2287 0.304336262436959 3385 689013
SGTC_3177 9107506 49.47 µM -0.512846759220134 0.314638104715792 no 2288 0.304029259146199 3366 8897194
SGTC_2476 5806916 10.51 µM -0.513013601486315 0.314578091459812 no 2289 0.30397090317818 3278 2870194
SGTC_1785 bathophenanthroline 24 µM -0.513906492852109 0.314257001226594 no 2290 0.303658683900215 3271 72812 An iron chelator.
SGTC_977 1348-1378 135 µM -0.513930607785912 0.314248331268487 no 2291 0.303650253564145 3306 X977
SGTC_1041 0206-0046 107 µM -0.51394151029033 0.314244411562711 no 2292 0.303646442193567 3327 50494
SGTC_2342 7990637 118.86 µM -0.517450911283921 0.312983790339307 no 2293 0.302420713933934 3402 2033102 YER133W GLC7
SGTC_172 1112-0046 2.638 µM -0.518253893497177 0.312695655376908 no 2294 0.302140568617687 3270 2802135 YIL048W NEO1
SGTC_2047 4141938 200 µM -0.519094343529807 0.312394198348472 no 2295 0.301847476332429 3308 3807862
SGTC_2313 7726885 200 µM -0.519178586126132 0.312363988689885 no 2296 0.301818105243524 3379 726423
SGTC_2110 5483698 200 µM -0.519484078500518 0.312254448749084 no 2297 0.301711606438484 3328 2848765 YHR062C RPP1
SGTC_1642 st009582 77.7 µM -0.520641959968945 0.311839419630242 no 2298 0.301308106656226 3436 6739311
SGTC_1700 st030840 7.9285 µM -0.520834221207202 0.311770528936258 no 2299 0.301241130783275 3392 5499307
SGTC_339 3091-4833 71.4 µM -0.52086955465254 0.311757869037327 no 2300 0.301228822800013 3385 3240077
SGTC_2044 5102272 200 µM -0.521069712795713 0.31168615699656 no 2301 0.301159104380181 3396 592666
SGTC_1100 amiodarone 5.07 µM -0.521152382823969 0.311656540318002 no 2302 0.301130311152038 3414 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1759 st043059 70 µM -0.522217197418594 0.311275177634745 no 2303 0.300759556734635 3285 669426
SGTC_363 0455-0021 3.06 µM -0.523488266460761 0.310820210153106 no 2304 0.300317257117573 3381 4597466
SGTC_1752 st044819 83.042 µM -0.524494638141495 0.310460193659036 no 2305 0.2999672740897 3295 441209 YML126C ERG13
SGTC_2094 5332512 191.667 µM -0.527445192331994 0.309405718020932 no 2306 0.298942233673316 3433 755774
SGTC_1240 0356-0016 42.1 µM -0.527578320037169 0.309358177439918 no 2307 0.298896021835427 3324 4305613
SGTC_1042 0350-0096 82 µM -0.531593209925515 0.307925941999247 no 2308 0.297503884295789 3312 3122515
SGTC_1887 st057648 70.8 µM -0.531671273011183 0.307898123362772 no 2309 0.297476845780629 3434 688672
SGTC_1527 coumarin 137 µM -0.533544761671407 0.307230816629894 no 2310 0.296828267129865 3444 323 A hepatotoxic, DNA x-linker.
SGTC_2658 polymyxin b sulfate 77.05 µM -0.533750992210302 0.307157399535103 no 2311 0.296756912223869 3377 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2639 lactacystin 53 µM -0.534344956389959 0.306945994297806 no 2312 0.296551446988063 3463 3870 A proteasome inhibitor.
SGTC_2864 9034755 47.6 µM -0.534822134056652 0.306776202495842 no 2313 0.296386427996937 3443 4930451
SGTC_85 0868-0259 160.055 µM -0.535127607814731 0.306667529015914 no 2314 0.296280810263821 3356 83173
SGTC_2871 9038510 12.99 µM -0.537728799642934 0.305742834120586 no 2315 0.295382146753091 3483 4945164
SGTC_2428 5615643 7.78 µM -0.537952032715652 0.305663534800254 no 2316 0.295305082332474 3402 2253075
SGTC_568 1193-0097 7.48 µM -0.540003841691631 0.304935095742295 no 2317 0.294597191532642 3356 3646150
SGTC_191 3914-0123 66.505 µM -0.540744180982607 0.30467244784728 no 2318 0.294341960793091 3308 3144412
SGTC_97 0535-0701 19.132 µM -0.540912513144816 0.304612743203334 no 2319 0.294283942810982 3419 2832013 YGL099W LSG1
SGTC_2413 inermin 26.06 µM -0.542380872136806 0.30409216131417 no 2320 0.293778076939654 3524 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2117 5521686 200 µM -0.543097960676242 0.30383807385958 no 2321 0.293531178337793 3350 803312
SGTC_619 1652-1634 108 µM -0.54455792360246 0.303321055132265 no 2322 0.293028800093679 3362 5400454
SGTC_344 k064-0035 6.43 µM -0.545173530976383 0.303103167145708 no 2323 0.292817087110252 3312 5088750
SGTC_1292 0kpi-0043 232 µM -0.545286136237955 0.303063319231069 no 2324 0.29277836881928 3389 3333905
SGTC_542 3381-0244 89.3 µM -0.545406531360965 0.303020717290714 no 2325 0.29273697468528 3485 1112843
SGTC_492 tmb-8 126 µM -0.545771037094867 0.302891752895474 no 2326 0.292611667251955 3361 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_897 1000-0139 31.4 µM -0.546258082438512 0.302719471585188 no 2327 0.292444272846552 3452 6151020
SGTC_314 1671-0008 2.74 µM -0.54654390633667 0.302618388268117 no 2328 0.292346057712159 3371 3913060
SGTC_2204 7233102 200 µM -0.547333267259542 0.302339304696459 no 2329 0.292074896316532 3352 2172480
SGTC_282 k297-0036 65.7 µM -0.548119968917149 0.302061276256727 no 2330 0.291804764969005 3447 5061378
SGTC_711 k292-0785 179 µM -0.549785832544138 0.301472922258354 no 2331 0.29123313852665 3436 4146315
SGTC_2452 5863136 48.41 µM -0.5506214264242 0.301177999417948 no 2332 0.290946608843983 3398 2184096
SGTC_2893 9048488 25.97 µM -0.551277605518574 0.300946492176814 no 2333 0.290721693848914 3386 6467338
SGTC_1843 st055809 45.5 µM -0.552882612136374 0.300380566548074 no 2334 0.290171897284077 3438 16413835
SGTC_2712 st079126 47.7 µM -0.553548478307498 0.300145923223739 no 2335 0.289943947253607 3388 3152970
SGTC_226 1,3-diallylurea 8.28947 mM -0.554663360516987 0.29975323768193 no 2336 0.289562470931884 3407 74537 YKL182W FAS1
SGTC_2676 harmalol 100 µM -0.556172575233961 0.299222030730653 no 2337 0.289046442646199 3466 5459187 A monoamine oxidase inhibitor
SGTC_370 0180-0345 38.7 µM -0.556363155801442 0.299154981383111 no 2338 0.28898131041509 3362 3989527
SGTC_1399 3562-5772 25 µM -0.558756849439295 0.298313422328531 no 2339 0.288163837614213 3410 23847490
SGTC_3070 9117005 49.47 µM -0.559883000104237 0.297917870849554 no 2340 0.287779622477884 3479 8779016
SGTC_2861 9024595 19.48 µM -0.560246943837472 0.297790089647427 no 2341 0.287655505517089 3353 16482810
SGTC_1199 1638-0010 4.46 µM -0.561754798667988 0.297260946047617 no 2342 0.287141546416834 3367 3111136
SGTC_3154 9100113 49.47 µM -0.562146221166648 0.297123656479034 no 2343 0.287008199409196 3368 25237525
SGTC_334 1502-1024 68.5 µM -0.562645276225962 0.296948657361725 no 2344 0.286838227463249 3477 3296216
SGTC_1035 k081-0041 55.2 µM -0.564575314786822 0.296272312475685 no 2345 0.286181329736244 3509 731709
SGTC_2755 lomerizine 42.69 µM -0.564859593415251 0.29617275222142 no 2346 0.286084634570757 3408 3949 A calcium channel blocker.
SGTC_2384 9036245 200 µM -0.565059836423537 0.296102632194133 no 2347 0.286016532787659 3396 6462766
SGTC_261 5-fluorouridine 15.376 µM -0.566486850951739 0.295603148608864 no 2348 0.285531434527221 3535 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2097 5376186 200 µM -0.56697048943523 0.295433953405548 no 2349 0.285367115724473 3452 742755
SGTC_2379 9035213 200 µM -0.568324108781152 0.294960642666581 no 2350 0.284907455778643 3479 646551
SGTC_3046 9092212 49.47 µM -0.568610771464084 0.294860452151934 no 2351 0.284810156648134 3460 25236637
SGTC_2819 7996655 46.38 µM -0.569486123296152 0.294554607989464 no 2352 0.284513142647817 3363 6456960
SGTC_2781 5567276 71.43 µM -0.570215735866776 0.294299796406112 no 2353 0.284265692267354 3488 2853274
SGTC_615 k087-0205 167 µM -0.570347544484477 0.294253774118517 no 2354 0.284220999937451 3400 9642773
SGTC_2317 5986382 200 µM -0.570744155273501 0.294115313578633 no 2355 0.284086541437824 3508 877883
SGTC_526 4469-0568 170 µM -0.571273253939161 0.293930647172057 no 2356 0.283907214444695 3484 2901964
SGTC_2226 7298446 200 µM -0.57204802001154 0.293660334531686 no 2357 0.283644721383084 3473 3283010
SGTC_987 1497-1013 404 µM -0.572371394303776 0.293547544641656 no 2358 0.283535195604632 3480 1676435
SGTC_452 diindolylmethane 8 µM -0.572635716122511 0.293455366597699 no 2359 0.283445685754587 3470 3071 Inhibits expression of several cancer promoting factors.
SGTC_2586 curcumin 80 µM -0.572859095900251 0.293377476896645 no 2360 0.283370051065222 3455 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_745 0469-0705 296 µM -0.572863230786017 0.293376035204618 no 2361 0.283368651115655 3580 3486736
SGTC_2085 5307070 144.047 µM -0.572878428233823 0.293370736407035 no 2362 0.28336350573949 3410 2840351
SGTC_124 0136-0217 7.121 µM -0.573236978040593 0.293245735990482 no 2363 0.283242125089057 3579 3976905
SGTC_607 4491-0986 66.8 µM -0.573361829780246 0.293202215004135 no 2364 0.283199864611454 3513 698981 YDR232W HEM1
SGTC_805 3852-0218 479 µM -0.574147057718016 0.292928567867755 no 2365 0.28293414586349 3395 6615355
SGTC_2835 9006588 71.43 µM -0.575676906314656 0.292395765670495 no 2366 0.282416793828764 3523 2345538
SGTC_701 4424-0219 185 µM -0.576119416160257 0.292241736294741 no 2367 0.282267234250624 3530 2911779
SGTC_1606 st000094 49.2 µM -0.576831010209757 0.29199412294101 no 2368 0.282026809486236 3531 1242210
SGTC_2081 5214970 32.255 µM -0.576878683847004 0.291977537439251 no 2369 0.282010705621703 3460 2063512
SGTC_372 0155-0182 15.9 µM -0.578394862291631 0.29145029290329 no 2370 0.281498780919106 3472 771486
SGTC_2287 7945887 168.79 µM -0.579042045387081 0.291225373092697 no 2371 0.281280401680796 3461 1245853
SGTC_3218 9131285 49.47 µM -0.580516554497755 0.290713230073487 no 2372 0.280783163178247 3547 17156417
SGTC_784 4579-0127 173 µM -0.580865864782617 0.290591965452476 no 2373 0.280665429993437 3536 1948547
SGTC_2505 galangin 7.89 µM -0.5809225420955 0.290572291902624 no 2374 0.280646329456739 3416 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2659 sanguinarine 24.21 µM -0.581374808666189 0.290415325689613 no 2375 0.280493935904554 3432 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_725 1497-0963 19 µM -0.582835172291504 0.289908754795454 no 2376 0.280002132505998 3510 3549977
SGTC_650 1328-0195 38 µM -0.583800240987275 0.289574219364175 no 2377 0.279677358051942 3491 2780821
SGTC_1442 4112-3290 3 µM -0.585414678795651 0.289014989492627 no 2378 0.279134460558993 3484 704353
SGTC_2057 5236571 38.335 µM -0.585599579812935 0.288950973523253 no 2379 0.279072315407196 3524 54684039 YBR257W POP4
SGTC_151 3013-0144 2.285 µM -0.585691642412413 0.288919102327603 no 2380 0.279041375716431 3490 906558 YHR107C CDC12
SGTC_1524 corynanthine 62.1 µM -0.587508519657546 0.28829045545325 no 2381 0.278431115130457 3522 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1368 1852-0141 284 µM -0.587877156733825 0.288162984294253 no 2382 0.278307375122552 3475 2838987
SGTC_2698 st077697 67.5 µM -0.588011901908922 0.288116397344577 no 2383 0.278262152046696 3416 3154499
SGTC_622 1348-1566 26.3 µM -0.589022740948806 0.28776702209344 no 2384 0.277923009294156 3486 7340407
SGTC_2273 7815444 169.05 µM -0.589111174488861 0.28773646642391 no 2385 0.277893348893755 3502 2824616
SGTC_1054 3429-0080 167 µM -0.589350074235858 0.287653929143746 no 2386 0.277813230208882 3534 1162877
SGTC_1469 k284-2957 126 µM -0.589504868114606 0.287600455506504 no 2387 0.277761323735433 3481 23884841
SGTC_2401 5128683 200 µM -0.590765869685516 0.287165016915536 no 2388 0.277338653145471 3423 708373
SGTC_1121 fusaric acid 630.51 nM -0.591029160988535 0.287074138749438 no 2389 0.277250441184709 3421 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2657 nystatin 74.44 µM -0.591646111794826 0.286861244105606 no 2390 0.277043794469249 3519 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2123 5259487 200 µM -0.593751242772674 0.286135378611542 no 2391 0.276339252112673 3493 2173474
SGTC_20 0481-0013 4.944 µM -0.594514259264744 0.285872500212057 no 2392 0.276084103994015 3491 182045
SGTC_2799 7812892 81.82 µM -0.595036190215433 0.285692748018304 no 2393 0.275909640070849 3529 20205235
SGTC_1661 st013063 9.66 µM -0.595981202113473 0.285367424305154 no 2394 0.275593892313967 3527 721395
SGTC_1308 1187-1617 41.4 µM -0.597519597154139 0.284838204045315 no 2395 0.275080263499291 3511 2882570
SGTC_2438 5259590 200 µM -0.599312617276935 0.284221982285665 no 2396 0.274482217807541 3481 1201127
SGTC_3316 9136639 10.545 µM -0.599667700338897 0.284100023663992 no 2397 0.274363859210086 3513 4903665
SGTC_2842 9000675 19.48 µM -0.599922558539383 0.284012504212092 no 2398 0.274278923749541 3460 2989072
SGTC_728 3030-5151 22.5 µM -0.600306636778137 0.283880634390839 no 2399 0.274150948232016 3532 3125388
SGTC_1331 1472-0049 76.2 µM -0.600346451586067 0.283866966010011 no 2400 0.274137683558318 3460 24051409
SGTC_215 1287-0124 461.5 µM -0.600435862230849 0.283836272579702 no 2401 0.274107896725618 3481 5560863
SGTC_1214 0358-0031 63.7 µM -0.601712923550778 0.283398048693208 no 2402 0.273682622973534 3566 4301366
SGTC_697 0508-1955 564 µM -0.603749585139462 0.282699839688324 no 2403 0.273005071080651 3529 6243113
SGTC_1275 0867-0008 21.1 µM -0.604277850103227 0.282518874815117 no 2404 0.272829465026593 3449 3422836
SGTC_120 rhodamine 6G 52.259 µM -0.604881577666104 0.28231212735285 no 2405 0.272628842295771 3507 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2495 cafestol 54.53 µM -0.606755664682645 0.281670807401993 no 2406 0.272006537393886 3557 16667697 An anti-infammatory.
SGTC_2121 5257820 149.641 µM -0.607069386992789 0.281563519068747 no 2407 0.271902432572528 3566 791256
SGTC_520 3584-0023 682 µM -0.60830910392857 0.281139747386559 no 2408 0.271491242047419 3455 1340790
SGTC_292 k038-0015 474 µM -0.610862155407543 0.280268011064191 no 2409 0.27064542036735 3533 46368540
SGTC_2298 7976326 193.81 µM -0.610979211592819 0.28022807378413 no 2410 0.270606671424999 3444 2235818
SGTC_2175 5807670 165.306 µM -0.612818290626228 0.279600978181285 no 2411 0.269998247710673 3513 241186
SGTC_1834 st055981 52.8 µM -0.614620376200957 0.278987158288274 no 2412 0.269402727338662 3590 471719 YDL150W RPC53
SGTC_1250 0485-0349 40.2 µM -0.615319276636028 0.278749277859853 no 2413 0.269171944816762 3486 6842794 YDL195W SEC31
SGTC_2161 5662504 8.5105 µM -0.616407596630444 0.278379049791802 no 2414 0.268812770423171 3504 2859334
SGTC_94 0334-0113 514.748 µM -0.617446582089594 0.278025828244994 no 2415 0.268470102467817 3498 6795178
SGTC_840 0245-0196 390 µM -0.619297982986069 0.277396954178155 no 2416 0.267860036490088 3598 3827528
SGTC_335 4077-0256 27.6 µM -0.620688797984564 0.27692498739348 no 2417 0.267402200646749 3555 3121989
SGTC_1271 0832-2808 169 µM -0.621703270989039 0.2765809787364 no 2418 0.267068500197155 3583 3663794
SGTC_1141 3253-0389 52.6 µM -0.622492303353767 0.276313562092809 no 2419 0.266809101574423 3535 5402031
SGTC_1410 3909-8106 77.9 µM -0.623439378854618 0.27599274950638 no 2420 0.266497913633692 3569 1039210
SGTC_1924 st058459 75.1 µM -0.623826471384137 0.275861678370657 no 2421 0.266370776511137 3529 688683
SGTC_875 0709-0210 25.7 µM -0.62417665150067 0.275743132283855 no 2422 0.266255789390215 3581 6251364
SGTC_1960 st011366 51.8 µM -0.625704626172875 0.275226161878086 no 2423 0.265754349169023 3568 3972846
SGTC_1088 bifonazole 369 nM -0.627275465378198 0.274695186711922 no 2424 0.265239341497443 3522 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_429 1112-0049 25.5 µM -0.627615158239922 0.274580430175165 no 2425 0.265128038129741 3491 2836170
SGTC_2779 methotrexate 400 µM -0.628358259872878 0.27432947479636 no 2426 0.264884637048657 3619 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_122 0236-0016 402.397 µM -0.628750690238788 0.274196991508597 no 2427 0.264756143305901 3609 6808838
SGTC_268 camptothecin 39.6153 µM -0.629311869139138 0.274007594154631 no 2428 0.264572451197232 3587 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1450 4112-4260 37.6 µM -0.630046578512974 0.273759728200625 no 2429 0.264332054971633 3571 1633175
SGTC_2954 9074818 52.69 µM -0.630810652941035 0.273502073163205 no 2430 0.264082168541363 3562 16648742
SGTC_1925 st057770 10.1 µM -0.631210813882075 0.27336718201681 no 2431 0.263951346098121 3453 5989122
SGTC_2663 amphotericin b 100 µM -0.631370359122276 0.273313409742571 no 2432 0.26389919605108 3549 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3332 9141069 11.198 µM -0.632212544203309 0.273029651030398 no 2433 0.26362400075006 3543 17332883
SGTC_470 aa-861 153 µM -0.632596711667598 0.272900261417085 no 2434 0.263498517508179 3525 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.632920119284478 0.272791359618736 no 2435 0.263392904308821 3591 65057 A dermal irritant. YDR527W RBA50
SGTC_2916 7875993 68.79 µM -0.633946560755706 0.272445866457389 no 2436 0.263057848953004 3572 1299250
SGTC_857 0438-0306 1.35 µM -0.634123203089102 0.272386431783036 no 2437 0.263000210592722 3606 4686136
SGTC_1809 st050081 57.6 µM -0.634369304021468 0.272303637179754 no 2438 0.262919918667668 3632 5036894
SGTC_1046 2001-0062 216 µM -0.634917708805191 0.272119184872004 no 2439 0.262741043363218 3520 739778
SGTC_1988 st071872 53.4 µM -0.63506044575599 0.272071186435665 no 2440 0.262694496513158 3586 16414116
SGTC_2038 4100038 30.985 µM -0.635710987860842 0.271852480684467 no 2441 0.262482406669767 3566 3596803
SGTC_2213 7173844 200 µM -0.63578578523179 0.271827340164208 no 2442 0.262458026838629 3546 892728
SGTC_2528 xanthyletin 44.79 µM -0.636259613702783 0.271668106177392 no 2443 0.262303611742639 3590 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3141 9094609 49.47 µM -0.639143184820501 0.270700060537916 no 2444 0.261364894319261 3511 25236309 YDL196W YDL196W
SGTC_3300 9124615 50.48 µM -0.639371363096361 0.27062353225703 no 2445 0.261290686927142 3613 24824903
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.63943045992565 0.270603713644939 no 2446 0.261271469414561 3587 688798
SGTC_2020 4017018 200 µM -0.639620858636663 0.270539866787911 no 2447 0.261209559193766 3577 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_217 ketoconazole 989 nM -0.63979364161792 0.270481933570116 no 2448 0.261153383445034 3545 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1231 0242-0792 125 µM -0.640294456864333 0.270314047903229 no 2449 0.260990591897714 3573 3707635
SGTC_273 hydroxyurea 18.1 mM -0.641122362193822 0.270036627834775 no 2450 0.260721593175779 3625 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1540 guanosine 70.6 µM -0.641625961243528 0.269867948199248 no 2451 0.260558036189739 3545 6802 Guanosine is a purine nucleoside
SGTC_361 000s-0510 1.45 µM -0.641944719379222 0.26976120797702 no 2452 0.260454538439807 3564 660
SGTC_2777 climbazole 1.536 µM -0.642575073688722 0.269550188070551 no 2453 0.260249930711196 3558 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1094 duloxetine 25.4 µM -0.644507290172796 0.268903867438169 no 2454 0.259623265897971 3600 60834 A selective serotonin reuptake inhibitor.
SGTC_3107 9121808 49.47 µM -0.645343299062526 0.26862446633293 no 2455 0.259352369520001 3537 662681
SGTC_2128 5255449 168.493 µM -0.64557395318882 0.268547405496766 no 2456 0.259277655157243 3582 736008
SGTC_1307 1187-1599 12.2 µM -0.645898121367931 0.268439120688494 no 2457 0.259172668171017 3540 1538471
SGTC_2809 7964133 12.99 µM -0.646233773432896 0.268327022954447 no 2458 0.25906398510861 3569 1253665
SGTC_2983 9022671 12.99 µM -0.647099957271619 0.268037852325515 no 2459 0.258783626479417 3589 6405161
SGTC_3319 9138450 16.7555 µM -0.647515304975315 0.267899246491336 no 2460 0.258649246173011 3535 2029690
SGTC_866 0495-0101 262 µM -0.648675843753857 0.267512154116831 no 2461 0.258273960647346 3543 635694
SGTC_84 0443-0269 128.823 µM -0.649626243004494 0.267195363005398 no 2462 0.257966838646175 3558 6150058
SGTC_356 1634-0012 32.5 µM -0.652225762095512 0.266329848601759 no 2463 0.257127771515456 3597 735457
SGTC_3275 9138069 49.47 µM -0.653171524566341 0.266015307707682 no 2464 0.256822852830151 3605 17617007
SGTC_1937 st074714 47.2 µM -0.653240963302633 0.265992221247754 no 2465 0.256800472842754 3550 17250970
SGTC_2762 leflunomide 42.06 µM -0.653641930582244 0.265858930568259 no 2466 0.256671261623015 3594 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3261 9137475 49.47 µM -0.654348720021287 0.265624060068766 no 2467 0.25644358203826 3487 17027690
SGTC_2098 5376439 882.5 nM -0.658051343512357 0.264395377364431 no 2468 0.255252569853849 3649 2844116
SGTC_123 0083-0120 66.675 µM -0.658758266365282 0.26416112062226 no 2469 0.255025505255223 3551 16001701
SGTC_2168 5727979 200 µM -0.658807798817284 0.264144710757475 no 2470 0.255009599325544 3550 695210
SGTC_714 4296-0578 26.1 µM -0.660767464596949 0.263495899781489 no 2471 0.254380725441635 3609 1589775
SGTC_616 4092-0450 108 µM -0.661147200655495 0.263370269973973 no 2472 0.254258958902931 3628 787165
SGTC_110 0850-0284 111.64 µM -0.661400788497023 0.263286391388817 no 2473 0.254177660197323 3497 3906265
SGTC_1449 4112-4002 201 µM -0.663326726846327 0.262649799386771 no 2474 0.253560661391498 3591 2059539
SGTC_561 1550-0330 72.9 µM -0.66403856349059 0.262414711228889 no 2475 0.253332814794777 3579 6812934
SGTC_312 4092-0653 6.84 µM -0.664179838147563 0.262368067274947 no 2476 0.253287608024141 3612 1148278
SGTC_1418 3966-3099 2.4 µM -0.664602962900474 0.262228391675975 no 2477 0.253152236834831 3621 740335
SGTC_1341 1486-1360 280 µM -0.665635026000504 0.261887862332063 no 2478 0.25282220639528 3617 3976547
SGTC_631 k072-0230 41.5 µM -0.66569858911414 0.261866897091034 no 2479 0.252801887756217 3622 5773147
SGTC_3329 9141233 27.5565 µM -0.666857932734944 0.26148465786753 no 2480 0.252431441878519 3616 4909101 YNL103W MET4
SGTC_2408 sulbentine 18.36 µM -0.667248110585198 0.261356079467588 no 2481 0.252306832451981 3577 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2996 9066192 71.4286 µM -0.667456956274442 0.261287270237605 no 2482 0.252240147627091 3618 6472854
SGTC_2743 auranofin 4.32 µM -0.670062508434945 0.260429591520419 no 2483 0.251408971752842 3578 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3082 9117008 49.47 µM -0.670478584684528 0.260292764630864 no 2484 0.251276376842196 3640 41448529
SGTC_1182 1222-0449 220 µM -0.670782227458849 0.260192934931176 no 2485 0.251179635502097 3610 658318
SGTC_327 1273-0057 3.96 µM -0.671746966527896 0.259875885283524 no 2486 0.25087239801077 3571 3108138
SGTC_1968 st069590 43.6 µM -0.673918733833174 0.25916289063576 no 2487 0.250181490560708 3590 6384066
SGTC_1 0258-0098 57.368 µM -0.674081829370828 0.259109386963961 no 2488 0.250129645512593 3561 6790032 YDR047W HEM12
SGTC_1810 st050138 53 µM -0.674391524213301 0.259007806948063 no 2489 0.250031214950128 3630 3444541
SGTC_2949 9072542 2.23 µM -0.675262387068037 0.258722274055167 no 2490 0.249754538092357 3652 16457352
SGTC_1952 st077036 64.1 µM -0.676845516446465 0.258203625437128 no 2491 0.249251987797751 3646 2937007
SGTC_1675 st018485 24.5 µM -0.679091753506667 0.257468662247768 no 2492 0.24853986362535 3651 3323024
SGTC_2694 st077685 81.9 µM -0.679509812852609 0.257331994325033 no 2493 0.248407446089034 3620 2838096
SGTC_2797 7859098 81.82 µM -0.680679782516089 0.25694971963787 no 2494 0.248037065880735 3671 972681
SGTC_2647 atorvastatin 60.16 µM -0.681161601227338 0.256792376621856 no 2495 0.247884621030496 3626 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3109 9122853 49.47 µM -0.681367600795797 0.256725120583312 no 2496 0.247819459139021 3679 1234709
SGTC_320 4092-0846 5.34 µM -0.687900744413573 0.254596905407024 no 2497 0.245757643885381 3629 1359356
SGTC_1915 st067105 30.6 µM -0.688895385524564 0.254273706898631 no 2498 0.245444551760225 3650 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2957 9076800 11.52 µM -0.690209757392168 0.253846945301634 no 2499 0.245031144083043 3621 16459615
SGTC_953 1188-0045 9.7 µM -0.691334175103466 0.253482158279091 no 2500 0.24467777994589 3642 6144426
SGTC_2738 aclarubicin 5.55 µM -0.691532721229936 0.253417773964879 no 2501 0.244615412539363 3572 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2602 kawain 100 µM -0.691803120657694 0.253330102968226 no 2502 0.244530488310256 3645 5369129
SGTC_1949 st076024 69.1 µM -0.691953131368669 0.253281472210945 no 2503 0.244483381362837 3648 2921930
SGTC_1627 st003713 25.6 µM -0.692114756204046 0.253229081858199 no 2504 0.244432632774826 3706 16195070 YER133W GLC7
SGTC_1621 st003705 32.4 µM -0.693189833822067 0.252880742760323 no 2505 0.244095213606081 3700 24207032
SGTC_1109 tnp00067 928.257 nM -0.693247195745166 0.252862163843148 no 2506 0.244077217305119 3661 676295
SGTC_540 1187-0821 17.3 µM -0.693706234967661 0.252713511803521 no 2507 0.243933227551253 3660 847520
SGTC_500 h-89 112 µM -0.694818777321548 0.252353424912624 no 2508 0.243584439543296 3693 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1128 3448-9350 235 µM -0.694991329478676 0.252297600696544 no 2509 0.243530367650971 3681 619386
SGTC_2096 5468907 200 µM -0.695505067234145 0.252131434390979 no 2510 0.243369418358088 3693 759785
SGTC_2054 5233173 129 µM -0.696485682488923 0.251814418857255 no 2511 0.243062360297883 3684 6889
SGTC_1513 0337-0559 19 µM -0.696487265104666 0.251813907395773 no 2512 0.243061864906039 3615 775073
SGTC_2003 4023581 200 µM -0.69801785644233 0.251319515753157 no 2513 0.242583013522716 3700 16641307
SGTC_658 3253-0951 102 µM -0.698028193362564 0.251316178601469 no 2514 0.24257978131512 3684 1184878
SGTC_1004 4084-0029 199 µM -0.699003514639718 0.251001413148133 no 2515 0.242274917192083 3674 716894 YLR208W SEC13
SGTC_2936 9038235 15.59 µM -0.699183989347868 0.250943191422777 no 2516 0.242218527516993 3672 4749415
SGTC_3257 9139206 32.98 µM -0.699316676956893 0.250900390529914 no 2517 0.242177073552867 3654 4910041
SGTC_3199 9111318 49.47 µM -0.699742036839576 0.250763208722605 no 2518 0.242044209506751 3635 8548020
SGTC_1688 st021091 57.6 µM -0.700444472996857 0.25053675467871 no 2519 0.241824885374559 3688 3656366
SGTC_192 3455-0609 60.9 µM -0.701371868551429 0.250237943408103 no 2520 0.241535486624488 3720 3769639
SGTC_1107 amlodipine 47 µM -0.703029497034461 0.249704318744881 no 2521 0.24101868363115 3560 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3102 9121669 49.47 µM -0.703147750397544 0.249666273665015 no 2522 0.240981838476279 3700 41905072
SGTC_1571 st070080 73.4 µM -0.704029068458439 0.249382828489503 no 2523 0.240707335608308 3737 4315245
SGTC_2674 ligustilide 100 µM -0.704102227094509 0.249359307260292 no 2524 0.240684556645441 3660 5319022 A signalling regulator.
SGTC_1842 st055362 61.2 µM -0.70469419825828 0.249169026028537 no 2525 0.240500281322001 3681 676032
SGTC_2464 5717415 7.67 µM -0.706921034879506 0.248453931312607 no 2526 0.239807775621947 3652 5285744
SGTC_439 amiodarone 34.4 µM -0.707652704419745 0.248219212274032 no 2527 0.239580477365089 3617 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.710677873811693 0.247249996700406 no 2528 0.238641936930059 3754 6728940
SGTC_586 0957-0265 8.15 µM -0.710874967090785 0.247186921473849 no 2529 0.238580859828828 3586 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1060 3448-7350 82 µM -0.712001426267853 0.246826589000016 no 2530 0.23823194641018 3650 570178
SGTC_3203 9113543 49.47 µM -0.712877681534635 0.246546486466398 no 2531 0.237960725449701 3746 17018012
SGTC_2136 5328288 199.296 µM -0.713745325183303 0.246269304584097 no 2532 0.237692336860958 3700 262395
SGTC_1387 3342-1166 1.8 µM -0.713768322548181 0.246261960001697 no 2533 0.237685225335984 3694 3418228
SGTC_1506 4226-2149 212 µM -0.714140695917081 0.246143052859008 no 2534 0.23757009176121 3725 991114
SGTC_3084 9116877 49.47 µM -0.714926000810761 0.245892388424512 no 2535 0.237327384861031 3618 27241325
SGTC_1907 st060210 83.7 µM -0.71509014039095 0.245840013407294 no 2536 0.237276672973038 3710 688793
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.715320476771259 0.245766525865212 no 2537 0.237205519231302 3679 77254
SGTC_3192 9110362 49.47 µM -0.716059797110328 0.245530729519186 no 2538 0.236977213290966 3758 16649480
SGTC_2254 7938975 95.19 µM -0.716271916490236 0.245463099320477 no 2539 0.236911732035367 3737 2969277
SGTC_1475 4092-1048 11.7 µM -0.716412169913239 0.245418387702343 no 2540 0.236868441265055 3702 2881759
SGTC_3225 9130819 49.47 µM -0.716599043716872 0.245358820698006 no 2541 0.236810767357301 3695 4547121
SGTC_3020 9089140 49.47 µM -0.717108582037937 0.24519644217485 no 2542 0.236653550386654 3723 17217859
SGTC_2368 9071271 200 µM -0.718067639076214 0.244890968840101 no 2543 0.236357791174761 3707 27209959
SGTC_2518 prenyletin 46.28 µM -0.719836702070938 0.244328034795089 no 2544 0.235812772207759 3649 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1351 1496-0003 46.5 µM -0.721405485085565 0.243829415966891 no 2545 0.235330036417887 3723 3891978
SGTC_2131 toluylene red 5.2905 µM -0.721814386194606 0.243699541949457 no 2546 0.23520430168999 3718 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2381 9035592 200 µM -0.721816760992622 0.243698787781906 no 2547 0.235203571561689 3706 4749657
SGTC_1009 4106-0057 9.87 µM -0.722619707264746 0.243443867390624 no 2548 0.234956778626033 3714 2928005
SGTC_648 0375-0473 33.3 µM -0.722908873586065 0.243352097799978 no 2549 0.234867935748884 3717 1713139
SGTC_901 1112-0062 60.1 µM -0.723930340072202 0.243028075729026 no 2550 0.234554251128483 3711 1908457
SGTC_39 0986-0283 58.349 µM -0.725625652278374 0.242490816720777 no 2551 0.234034145442415 3750 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_829 1635-0120 117 µM -0.727723583079552 0.241826856064699 no 2552 0.233391405508257 3732 285054
SGTC_1559 coumarin 343 70.1 µM -0.72883513635625 0.241475467905481 no 2553 0.233051257890169 3723 108770 A hepatotoxic, DNA x-linker.
SGTC_2806 7952793 58.44 µM -0.729128602280268 0.241382742712549 no 2554 0.232961500020076 3743 2972490
SGTC_44 0929-0055 61.211 µM -0.730012344344487 0.241103627323979 no 2555 0.232691319547862 3679 1379590
SGTC_3288 9119690 36.221 µM -0.730224138764105 0.241036761616505 no 2556 0.232626594955475 3718 17595618 YKL019W RAM2
SGTC_2866 9034245 58.44 µM -0.730795787286736 0.24085633656423 no 2557 0.232451948550129 3730 6462273
SGTC_886 0866-0150 153 µM -0.731197403192578 0.240729621563083 no 2558 0.232329293048466 3741 271463
SGTC_1979 st071809 45.3 µM -0.731773558707195 0.240547900438271 no 2559 0.232153395173481 3814 4976333
SGTC_3195 9113082 49.47 µM -0.732716945827594 0.240250514739126 no 2560 0.231865543129113 3671 17018038
SGTC_1465 k213-0056 144 µM -0.732856728347775 0.240206467879741 no 2561 0.231822908748705 3628 24048857 YMR208W ERG12
SGTC_1973 st070275 50.2 µM -0.733635598608933 0.23996111872948 no 2562 0.231585429327155 3651 17118334
SGTC_2945 9067681 61.76 µM -0.733905931258689 0.239875994162257 no 2563 0.231503035960291 3799 16456930
SGTC_2289 7946404 165.07 µM -0.734506240496296 0.239687022768817 no 2564 0.231320129095072 3766 1246120 YPR165W RHO1
SGTC_1355 1499-0035 1.68 µM -0.735127422700859 0.239491566332732 no 2565 0.231130947378709 3736 1548538
SGTC_232 clozapine 119 µM -0.73677557958782 0.238973391950417 no 2566 0.230629418087329 3699 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1445 4239-0156 97.7 µM -0.739877319520158 0.237999881041477 no 2567 0.229687218797138 3812 4008346
SGTC_807 1315-0151 48 µM -0.740554869498077 0.23778751514318 no 2568 0.229481690269887 3739 4011080
SGTC_577 r071-0003 38.6 µM -0.740934228375522 0.237668657303412 no 2569 0.229366660279086 3773 4568517 YMR134W ERG29
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.741930275648762 0.237356738547791 no 2570 0.229064790636968 3744 75037 A free radical scavenger.
SGTC_2684 capsaicin 100 µM -0.742530927605195 0.237168749138695 no 2571 0.228882860275165 3754 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_305 1682-2595 20.8 µM -0.743109229936372 0.236987831931771 no 2572 0.228707776001452 3774 226033
SGTC_1364 1653-0028 37.6 µM -0.744616895033328 0.236516527954584 no 2573 0.228251675703817 3748 5718652
SGTC_2955 9076254 12.21 µM -0.746247032873529 0.236007519253801 no 2574 0.227759100638482 3699 16459619
SGTC_2678 equilin 100 µM -0.746658170470332 0.235879237389856 no 2575 0.227634962661538 3751 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1616 st002734 56.1 µM -0.747088967277448 0.235744862767798 no 2576 0.227504929704609 3727 4026101
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.749248505171061 0.235071893871905 no 2577 0.226853719365244 3694 756377
SGTC_1175 0741-0056 27.6 µM -0.750540470179663 0.234669791436192 no 2578 0.226464629565019 3819 765927
SGTC_3183 9108214 49.47 µM -0.750762370167912 0.234600767079994 no 2579 0.226397839825711 3690 4974831
SGTC_3245 9134821 49.47 µM -0.750948958026279 0.234542735629699 no 2580 0.226341687305114 3760 17014901
SGTC_220 paclitaxel 373.376 µM -0.751115991894067 0.234490792482215 no 2581 0.226291426117057 3690 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3297 9117502 71.43 µM -0.751420708334556 0.234396050066353 no 2582 0.226199751912329 3752 7453720
SGTC_1226 3909-7979 35.4 µM -0.751515748758593 0.234366504438137 no 2583 0.226171163212335 3778 6615510
SGTC_1360 1598-0022 39.8 µM -0.751631393683614 0.234330556179308 no 2584 0.226136379315134 3817 761525
SGTC_2361 9034121 116 µM -0.752456355990158 0.234074204957067 no 2585 0.225888333329259 3773 6496917
SGTC_1343 1487-0095 224 µM -0.752701598719028 0.233998027467139 no 2586 0.2258146245173 3726 4560101 YGL055W OLE1
SGTC_768 0384-0033 77.3 µM -0.752842631399505 0.233954226004868 no 2587 0.225772242668434 3751 3965305 YMR134W ERG29
SGTC_3262 9137218 49.47 µM -0.753942386868289 0.233612823453998 no 2588 0.225441908609721 3603 17650664
SGTC_2971 9092186 9.93 µM -0.754267515291313 0.233511945154695 no 2589 0.225344302062015 3782 25236400
SGTC_1690 st023502 41.2 µM -0.754291327292673 0.233504557903162 no 2590 0.225337154420412 3731 24207482
SGTC_2144 5628481 200 µM -0.754751879519508 0.233361705234893 no 2591 0.225198935846571 3744 2818399
SGTC_2876 9059903 25.97 µM -0.756094750287227 0.232945454673246 no 2592 0.224796194632284 3719 6916095
SGTC_1127 asiatic acid 681.4 nM -0.758790493091799 0.232111099690374 no 2593 0.223988946784337 3751 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1691 st019933 84.6 µM -0.759413789346571 0.231918421324735 no 2594 0.223802533649688 3729 6176082
SGTC_3018 9082602 49.47 µM -0.760656506626461 0.231534528509899 no 2595 0.223431129678121 3757 17332089
SGTC_1889 st059080 5.18 µM -0.760715397006677 0.23151634524005 no 2596 0.223413538145919 3742 176925 Isolated from Daphnopsis sellowiana.
SGTC_2849 9019321 12.99 µM -0.761223516041868 0.231359489096348 no 2597 0.223261787308739 3775 16489627
SGTC_2380 9035439 200 µM -0.761544289554029 0.231260496967392 no 2598 0.223166017829512 3880 6462575
SGTC_537 1334-0398 209 µM -0.762217897701529 0.231052695431473 no 2599 0.222964982911029 3744 5846986
SGTC_2982 9019404 25.97 µM -0.762685030173922 0.230908650843056 no 2600 0.222825630197041 3698 22333232
SGTC_1365 1672-3266 55.4 µM -0.763168773737243 0.230759536933653 no 2601 0.222681374460548 3771 6415873
SGTC_218 alverine citrate 93.75 µM -0.76338945638431 0.230691529397197 no 2602 0.222615583026673 3817 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2828 7998861 71.43 µM -0.764943972221145 0.230212793268283 no 2603 0.222152454107502 3673 2988188
SGTC_553 k007-0256 45.7 µM -0.765176865048324 0.230141118373137 no 2604 0.222083116937758 3828 6287000
SGTC_1071 trifluoperazine 6.31 µM -0.766310514000266 0.229792405896657 no 2605 0.22174578189933 3864 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2427 5545055 42.75 µM -0.766574509578419 0.229711242868606 no 2606 0.221667267914687 3759 5372858
SGTC_1940 st075990 51.1 µM -0.76716199170597 0.22953068448753 no 2607 0.221492603967094 3852 1084979
SGTC_1059 3448-6867 171 µM -0.767582987759322 0.229401343323086 no 2608 0.221367486297164 3732 3934407
SGTC_1222 0366-0074 1.18 µM -0.768244415727352 0.229198217624336 no 2609 0.221170995259894 3829 286520
SGTC_160 3453-0671 289.699 µM -0.768630662654553 0.229079647172641 no 2610 0.221056298679393 3810 5322268
SGTC_656 4090-1979 187 µM -0.768644226316568 0.22907548401215 no 2611 0.221052271549196 3780 22330961
SGTC_2035 5154463 94.595 µM -0.76945203191689 0.228827616872441 no 2612 0.220812505086104 3778 2769623
SGTC_1444 4112-3581 28 µM -0.771164803600673 0.228302568177469 no 2613 0.220304626663743 3807 2877249
SGTC_1945 st075991 56.6 µM -0.771802683435621 0.228107199844659 no 2614 0.220115651084604 3779 1084980
SGTC_4 0960-0234 25.671 µM -0.773724112367779 0.2275192775854 no 2615 0.2195469788708 3774 6821112
SGTC_1862 st057513 3.81 µM -0.77404143109029 0.227422266004776 no 2616 0.219453145468352 3777 5393163
SGTC_2043 5101342 149 µM -0.774050646993821 0.227419448840822 no 2617 0.21945042060449 3809 678451
SGTC_1263 0774-1208 64.8 µM -0.77471775021467 0.227215577577485 no 2618 0.219253229998575 3793 906585
SGTC_2568 diosmetin 100 µM -0.776534547544509 0.226660874578089 no 2619 0.218716715293121 3807 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2667 digitoxin 100 µM -0.778197977842736 0.226153668393576 no 2620 0.218226154377633 3763 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2491 paeonol 100 µM -0.778542109342031 0.226048817388721 no 2621 0.218124746036021 3688 11092 Increases levels of cortical cytochrome oxidase.
SGTC_418 lividomycin a 100 µM -0.779867587228139 0.225645223696468 no 2622 0.217734409342891 3788 72394 An antibiotic.
SGTC_1430 4049-0248 69.1 µM -0.779979962436373 0.225611025418834 no 2623 0.217701334787577 3811 22774488
SGTC_665 3914-0008 307 µM -0.78120500966294 0.225238406587485 no 2624 0.217340963879142 3764 1069549
SGTC_1130 3454-2858 15.9 µM -0.783233264691327 0.22462224548315 no 2625 0.21674507207052 3853 715628 YIL048W NEO1
SGTC_1011 4112-3381 17.4 µM -0.784185679806501 0.22433324269613 no 2626 0.216465583284876 3895 2877139
SGTC_176 1486-1328 72.834 µM -0.786283653440656 0.223697374459095 no 2627 0.215850663469754 3866 22310231
SGTC_1010 4112-3296 15.2 µM -0.787802072544313 0.223237801524097 no 2628 0.21540624429455 3879 704384
SGTC_1192 1488-0095 21.4 µM -0.788070433490112 0.223156633870937 no 2629 0.215327754188183 3856 915875
SGTC_1844 rapamycin 4 nM -0.788604475693963 0.222995159052121 no 2630 0.215171607111803 3753 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_603 3794-0023 45.9 µM -0.789472801888935 0.222732751108222 no 2631 0.214917860059713 3805 3802260
SGTC_2750 bromebric acid 70.15 µM -0.789547698064971 0.222710125751014 no 2632 0.214895981632682 3894 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1756 st041558 35.5 µM -0.790428772341916 0.222444060722788 no 2633 0.214638702225721 3867 3955792
SGTC_1553 gossypol 38.6 µM -0.791344337577721 0.222167772350824 no 2634 0.214371541004517 3699 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1850 st056238 17 µM -0.791588764019492 0.222094045385932 no 2635 0.214300250280049 3815 5393177
SGTC_1447 4239-0816 81.9 µM -0.79504810092176 0.22105209548184 no 2636 0.213292761238109 3826 1341554
SGTC_5 0352-0601 109.883 µM -0.795993002033714 0.220767979082719 no 2637 0.21301805144084 3740 762456
SGTC_2153 5569715 200 µM -0.797208984667356 0.220402660785115 no 2638 0.212664834421443 3834 2054701
SGTC_2824 7998404 51.95 µM -0.797927403496023 0.220186988773924 no 2639 0.212456309893845 3796 837851
SGTC_2394 5221648 200 µM -0.798896722237586 0.219896187575201 no 2640 0.212175149855693 3918 788586
SGTC_865 0488-0499 301 µM -0.799265092766159 0.219785732121153 no 2641 0.212068357577845 3788 9634651
SGTC_1714 st033236 13.627 µM -0.800696995147201 0.219356680579117 no 2642 0.211653541275938 3841 2916566
SGTC_706 4262-0057 46.9 µM -0.801522261027438 0.219109618829631 no 2643 0.211414681002259 3810 883298
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.801875406450986 0.219003945771726 no 2644 0.211312516846303 3866 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2619 obliquin 87.91 µM -0.801980909739194 0.21897238130609 no 2645 0.211282000600181 3800 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1075 aripiprazole 15.2 µM -0.802844472708439 0.218714118986169 no 2646 0.211032316826877 3865 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1491 4138-0063 26.5 µM -0.803993883666418 0.218370641362096 no 2647 0.210700253684399 3785 23883227
SGTC_1403 3909-7815 62.9 µM -0.804517260807518 0.218214343968276 no 2648 0.210549152415753 3785 6615483
SGTC_1920 st075728 45.7 µM -0.805177521201676 0.218017260781525 no 2649 0.210358623095882 3802 3400306
SGTC_2376 9072922 81.32 µM -0.807922011573947 0.217199149884651 no 2650 0.209567739517379 3887 17087968
SGTC_2055 5235184 200 µM -0.808377937844436 0.217063413842023 no 2651 0.209436524230981 3884 2836034
SGTC_60 0986-0278 202 µM -0.809728259267002 0.216661690722256 no 2652 0.209048186300157 3736 3110598
SGTC_646 4092-0839 27.3 µM -0.810244842067231 0.216508120181088 no 2653 0.208899734854015 3890 877796
SGTC_1261 0712-0010 12.7 µM -0.810256449793162 0.216504670141878 no 2654 0.208896399831878 3825 2840123
SGTC_165 k038-0023 64.381 µM -0.810953861304122 0.216297444415578 no 2655 0.208696083707537 3857 46368543
SGTC_1008 4106-0037 6 µM -0.812863442534774 0.215730627993979 no 2656 0.208148178204965 3797 2905394
SGTC_1882 5615643 20 µM -0.812956318132906 0.215703081928192 no 2657 0.208121551592797 3765 2253075
SGTC_68 0986-0284 82.829 µM -0.813280965641687 0.215606810424061 no 2658 0.208028493820499 3946 423278 YIL048W NEO1
SGTC_409 arachidonic acid 100 µM -0.81329229366657 0.21560345164292 no 2659 0.208025247170714 3849 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3133 9127736 49.47 µM -0.813545652018259 0.215528338333156 no 2660 0.207952641636367 3809 27243420
SGTC_1441 4106-0040 13 µM -0.814876598526448 0.21513400114365 no 2661 0.207571474791595 3829 2904180
SGTC_1519 esterone 74 µM -0.815595600482739 0.214921147254937 no 2662 0.207365733278687 3844 698 A steroid.
SGTC_716 1683-5115 658 µM -0.816208043752137 0.21473993558924 no 2663 0.207190578525578 3836 723597
SGTC_899 1083-0020 478 µM -0.81663053602225 0.214614978994428 no 2664 0.207069799530702 3929 767123
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.819578734220652 0.213744195129602 no 2665 0.206228150387764 3879 6710655
SGTC_3201 9113999 49.47 µM -0.820113515203791 0.213586462269558 no 2666 0.2060756991314 3910 16649224
SGTC_182 3448-4371 550.524 µM -0.820247295849108 0.213547014473883 no 2667 0.20603757242465 3820 3491403
SGTC_288 1315-0019 35.1 µM -0.821627242627162 0.213140358454245 no 2668 0.205644539788645 3929 6811474
SGTC_3013 9080133 71.4286 µM -0.821916134103643 0.213055282342867 no 2669 0.205562314885393 3924 17050193
SGTC_1811 st050069 61.5 µM -0.822065033961525 0.213011440324537 no 2670 0.20551994231655 3801 3877702
SGTC_1563 conessine 56.1 µM -0.823146755218167 0.212693096781822 no 2671 0.205212271624384 3937 441082 An anti-amoebic, histamine inhibitor.
SGTC_2431 5490079 200 µM -0.823289241553791 0.212651184694013 no 2672 0.205171765076596 3925 5722345
SGTC_2979 9012552 45.46 µM -0.827307597160897 0.211471180185198 no 2673 0.204031369410466 3911 17100905
SGTC_703 3875-0075 71.8 µM -0.827521759645978 0.211408398413269 no 2674 0.203970697007752 3897 2850814
SGTC_2962 9082311 13.18 µM -0.827587287305337 0.211389191149063 no 2675 0.203952135117718 3869 16459453
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.828399425058895 0.21115122469496 no 2676 0.203722166022283 3678 88881 An O-methylated flavonoid and antioxidant.
SGTC_2716 st080858 38.6235 µM -0.830120355649235 0.210647489738227 no 2677 0.203235369649582 3863 5296050
SGTC_1390 3413-2614 145 µM -0.832793356772297 0.209866473122076 no 2678 0.2024806410157 3923 3421432
SGTC_869 0564-0080 44.1 µM -0.833133712746068 0.209767147784275 no 2679 0.202384661058377 3894 6843321
SGTC_155 k072-0202 43.6 µM -0.833960337357539 0.209526030839532 no 2680 0.20215166726564 3795 5857737
SGTC_696 1560-0013 611 µM -0.836931967864802 0.208660587795079 no 2681 0.201315404988758 3919 1650269
SGTC_683 panaxydol 45 µM -0.838748079060659 0.208132711473208 no 2682 0.200805346061919 3869 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3294 9122953 26.2835 µM -0.838810172925959 0.208114677029287 no 2683 0.200787920582801 3887 16459826
SGTC_2675 theaflavin digallate 100 µM -0.841337215362592 0.207381509649274 no 2684 0.200079523786659 3848 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1634 st006576 41 µM -0.842577290099782 0.207022287678782 no 2685 0.199732448274994 3865 3915356
SGTC_2549 cedrol 20.94 µM -0.843117562963508 0.206865897904263 no 2686 0.199581348574637 3816 6708665 A sedative which affects the nervous system.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.843613908446253 0.206722285192996 no 2687 0.199442594821236 3867 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1791 st048313 56.1 µM -0.84366553194143 0.206707351829475 no 2688 0.199428166769054 3859 1204976
SGTC_2362 9071156 126 µM -0.843754456256642 0.20668162978575 no 2689 0.199403315127554 3926 653133
SGTC_509 pifithrin 175 µM -0.844427656792398 0.206486962836618 no 2690 0.199215236545779 3931 4817 A p53 inhibitor.
SGTC_609 0986-0026 86.3 µM -0.844759826686249 0.206390950510902 no 2691 0.199122474391376 3861 2848610
SGTC_308 4092-1169 104 µM -0.845927342496926 0.206053694880815 no 2692 0.198796639073328 3836 2268590 YDL196W YDL196W
SGTC_1993 st073995 70.8 µM -0.848016780407749 0.205450943725122 no 2693 0.198214312772167 3888 3098394
SGTC_1215 3852-0577 11.2 µM -0.849440583773939 0.205040812164265 no 2694 0.197818089348961 3969 2884876
SGTC_360 0957-0399 1.01 µM -0.84953923157754 0.205012414355956 no 2695 0.197790654861656 3937 6752301 YPR165W RHO1
SGTC_1202 1988-0068 29.6 µM -0.851091935435438 0.204565744551094 no 2696 0.19735914245702 3858 2850480
SGTC_296 1222-0039 74.9 µM -0.852053864954647 0.2042893148638 no 2697 0.197092098190424 3893 5984176
SGTC_2794 7785382 27.27 µM -0.852472380040928 0.204169115649874 no 2698 0.196975981203885 3825 2205081
SGTC_213 1246-0773 967 nM -0.853197969249569 0.203960823358823 no 2699 0.196774764678369 3894 6251622
SGTC_2114 5491910 81.25 µM -0.854229059880702 0.203665049780839 no 2700 0.19648904235025 3977 2849228
SGTC_2402 5553605 200 µM -0.85543142990778 0.20332046703796 no 2701 0.196156175025195 3977 6758546
SGTC_1104 tacrolimus 29.8 µM -0.857690635347159 0.202673951513511 no 2702 0.195531656206078 3935 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2182 6325192 200 µM -0.857737820979418 0.202660461539194 no 2703 0.195518625428529 3832 736248
SGTC_3058 9093861 49.47 µM -0.858201721159414 0.202527864963484 no 2704 0.195390542901297 3905 17217477
SGTC_463 ikarugamyin 104 µM -0.859202494380337 0.202241990667044 no 2705 0.1951144037246 3963 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_806 3966-4455 5.86 µM -0.862706199299611 0.201243048909001 no 2706 0.194149511532811 3905 714982
SGTC_1974 st069448 26.9 µM -0.864694065679547 0.200677605778269 no 2707 0.193603363731664 3908 6323587 YNR016C ACC1
SGTC_2108 5365811 200 µM -0.868838054826564 0.199501930214658 no 2708 0.192467857610558 3971 780283
SGTC_3132 9126706 49.47 µM -0.868861287757737 0.199495350595701 no 2709 0.192461502989268 4006 850858
SGTC_1347 1493-0251 600 nM -0.869544685836816 0.199301869138681 no 2710 0.192274638803297 3980 3986378
SGTC_1570 verbenone 133 µM -0.870127439567096 0.19913697108043 no 2711 0.192115381882146 3966 29025 A natural terpanoid with antifungal properties.
SGTC_1492 4158-0558 28.5 µM -0.871644563060681 0.198708066114503 no 2712 0.191701155926106 3929 3967268
SGTC_1386 3228-0095 33.8 µM -0.873318978343355 0.198235340506863 no 2713 0.191244619488142 3957 870181
SGTC_1863 st057641 20.1 µM -0.8784388378433 0.196794104314557 no 2714 0.189852807789322 3950 3921635
SGTC_510 ag-490 170 µM -0.879026803697293 0.196628999574806 no 2715 0.18969337146003 4058 5328779
SGTC_1306 1185-0270 9.02 µM -0.879396868241232 0.196525126019845 no 2716 0.189593064792087 3967 1548076
SGTC_1023 4482-3888 16 µM -0.879853148834655 0.196397098230968 no 2717 0.18946943403674 3959 3303168
SGTC_2050 5263056 171 µM -0.880562703075758 0.196198104838429 no 2718 0.189277276525058 3976 763468 YGL055W OLE1
SGTC_1170 0310-0127 64.8 µM -0.882678427215826 0.195605479432861 no 2719 0.188705020532502 3968 774975
SGTC_1033 k072-0102 21.3 µM -0.883472033303836 0.19538346680824 no 2720 0.188490643187382 3927 5965931
SGTC_2891 9063876 19.48 µM -0.883896113946605 0.195264892321502 no 2721 0.188376147595143 3936 6472478
SGTC_904 1141-0088 396 µM -0.885608789328793 0.194786467103594 no 2722 0.187914186828053 3968 1378119
SGTC_2847 9005661 71.43 µM -0.885926352417379 0.194697836253725 no 2723 0.187828607319033 3925 2991449
SGTC_2210 7115885 190.385 µM -0.887245261209248 0.194329995627102 no 2724 0.187473434581498 3992 2927039
SGTC_2013 4024628 200 µM -0.887282101776294 0.194319726956296 no 2725 0.187463519642099 3992 5230760
SGTC_995 3931-2021 34.6 µM -0.887944761604756 0.194135078415347 no 2726 0.187285232672632 3955 730143
SGTC_1086 cerivastatin 2.18 µM -0.888769751746889 0.193905346346016 no 2727 0.187063417697191 3916 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2638 epoxomicin 18 µM -0.889552740423543 0.19368746358992 no 2728 0.186853046024758 3960 9915668 A protesome inhibitor.
SGTC_1938 st074717 56.4 µM -0.889778473614019 0.1936246764045 no 2729 0.186792423728593 3793 17250979
SGTC_383 2324-0395 7.37 µM -0.890989452739064 0.193288057198765 no 2730 0.186467414311099 3981 3146421
SGTC_1715 st032160 10.2275 µM -0.891616329712967 0.193113942857615 no 2731 0.186299307198877 3905 5289825
SGTC_2488 5268135 45.7 µM -0.892341909870236 0.192912533422401 no 2732 0.186104848530412 4017 1270356 YLR208W SEC13
SGTC_2951 9072950 58.06 µM -0.892531537117513 0.192859917088991 no 2733 0.186054048340016 3944 16488155
SGTC_278 4092-0821 23.9 µM -0.892981813640573 0.192735012893671 no 2734 0.185933455958101 3969 877900
SGTC_322 k048-0136 19.3 µM -0.893841229141727 0.192496753066759 no 2735 0.185703423160812 4019 6823282
SGTC_162 k030-0015 37.8 µM -0.894660885140124 0.192269683793671 no 2736 0.185484197037717 4040 1809920 YMR134W ERG29
SGTC_1693 xanthone 101.9 µM -0.895095501888433 0.192149348423984 no 2737 0.185368019144457 4016 7020 An insecticide.
SGTC_2523 spermine 47.74 µM -0.895148157002609 0.192134772565357 no 2738 0.18535394691531 3968 1103 A DNA binding polyamine.
SGTC_772 k072-0172 35.3 µM -0.895320833853698 0.192086977332988 no 2739 0.185307803189451 4008 5861980
SGTC_1672 st016598 6.51 µM -0.896070944113923 0.191879438739816 no 2740 0.185107437106378 4007 4665860 YNL267W PIK1
SGTC_1293 1000-1278 195 µM -0.898693736103887 0.191154851061985 no 2741 0.184407907195751 4016 678847
SGTC_1379 2144-0755 36.5 µM -0.901669133775324 0.190334884681494 no 2742 0.183616327100034 4052 5392327
SGTC_812 4251-0442 148 µM -0.902802239143193 0.190023189982492 no 2743 0.183315431278918 3977 5723007
SGTC_1186 1319-0216 26 µM -0.903840201514279 0.189737942721796 no 2744 0.183040070638917 4033 4565136
SGTC_2924 9010168 62.78 µM -0.904739690017537 0.189490963218354 no 2745 0.182801654511922 4089 2993929
SGTC_412 gemfibrozil 100 µM -0.908003524771103 0.18859644933578 no 2746 0.181938179697717 3917 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1575 cyproterone acetate 48 µM -0.911050578593206 0.187763702275659 no 2747 0.181134362309831 4009 9880 An androgen receptor antagonist and liver toxin.
SGTC_2723 salbutamol 83.58 µM -0.91141973623026 0.187662967506426 no 2748 0.181037129280343 4001 9884233 β2-adrenoceptor agonist
SGTC_2479 5617353 43.85 µM -0.911582403306905 0.187618589939892 no 2749 0.18099429451685 4031 2731746
SGTC_1050 3232-1156 69.3 µM -0.911843717012642 0.187547313942566 no 2750 0.180925496650126 3959 700529
SGTC_295 k015-0027 31 µM -0.911849082148168 0.18754585072206 no 2751 0.180924084305504 4001 3887424
SGTC_822 1487-0950 154 µM -0.912872378490685 0.187266898567234 no 2752 0.180654833094896 4001 1958375
SGTC_2373 9071805 200 µM -0.913365678347424 0.18713251596101 no 2753 0.180525125129569 3942 10149009
SGTC_1296 1068-0102 11.9 µM -0.915445163257191 0.186566687605009 no 2754 0.179978988979934 3997 767053
SGTC_2919 7978188 46.38 µM -0.915745539434045 0.186485042831743 no 2755 0.179900186879285 3980 2980291
SGTC_1322 1348-1070 12 µM -0.916418631254547 0.186302171176033 no 2756 0.179723683499489 3945 6758089
SGTC_1499 4480-0877 67.3 µM -0.918208341155399 0.185816467387496 no 2757 0.179254901308616 3916 2861909
SGTC_1958 st076513 41.9 µM -0.918324808932735 0.185784886802023 no 2758 0.179224421350379 3963 732122 YGL099W LSG1
SGTC_2763 lisinopril 49.32 µM -0.918717093644004 0.185678542124764 no 2759 0.179121783274151 3882 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_892 0929-0076 29 µM -0.920819006273741 0.185109377007192 no 2760 0.17857246511921 3975 5751038
SGTC_3024 9090631 49.47 µM -0.921413421342358 0.184948615470802 no 2761 0.178417312112676 3960 25236383
SGTC_2143 5623677 140.463 µM -0.922837815369464 0.184563736526762 no 2762 0.178045865411637 3925 5375313
SGTC_988 1497-1057 103 µM -0.923246820304988 0.184453313301026 no 2763 0.177939297214516 3918 3533044
SGTC_2374 9071832 200 µM -0.923528415128321 0.184377312172112 no 2764 0.177865949718898 3908 17381698
SGTC_32 0928-0142 34.1 µM -0.92793501856295 0.183190529498246 no 2765 0.176720639032803 3975 2244242
SGTC_1149 3909-7961 23.3 µM -0.928157376003169 0.183130770927 no 2766 0.176662970436192 4024 735261
SGTC_1966 st070145 16.1 µM -0.930641143613433 0.182464085041974 no 2767 0.176019612121408 3956 3748532
SGTC_3098 9119039 49.47 µM -0.931396712026349 0.182261578632837 no 2768 0.175824195524831 4003 17161528
SGTC_38 0929-0051 58.268 µM -0.935018091020555 0.181292932646236 no 2769 0.174889488124943 4024 1379719
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.939962288719209 0.179975675227042 no 2770 0.17361845237105 3939 1241132 A phosphatase inhibitor.
SGTC_2790 5423970 71.43 µM -0.943468317298883 0.179045233518266 no 2771 0.172720706736924 4107 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2347 9049783 174.81 µM -0.944221813921813 0.17884566384523 no 2772 0.17252815512215 4068 6467988 YPL169C MEX67
SGTC_1262 0737-0114 49.6 µM -0.945105182784936 0.178611874829885 no 2773 0.172302589809314 4106 765919
SGTC_1939 st074455 53.6 µM -0.945393184474719 0.178535695027477 no 2774 0.172229090221056 4059 1644229
SGTC_2650 prasterone 100 µM -0.948497686915876 0.177715817623885 no 2775 0.171438074902728 4006 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3219 9131112 49.47 µM -0.948526578221288 0.177708198805284 no 2776 0.171430724430697 3967 17612988 YMR079W SEC14
SGTC_2125 5246583 200 µM -0.949373540115146 0.177484941214318 no 2777 0.171215331475067 4011 835267
SGTC_390 dec-rvkr-cmk 16.7 µM -0.949701585970038 0.177398516520578 no 2778 0.171131951841754 4061 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_65 0798-0905 34.986 µM -0.950799763663685 0.177109391604194 no 2779 0.170853016297118 4131 3602145
SGTC_2277 7947813 106.88 µM -0.951998265369837 0.176794193598539 no 2780 0.170548930801895 4108 1246798
SGTC_2968 9090663 33.37 µM -0.954668972396321 0.176093091757487 no 2781 0.169872562694417 4009 25236811
SGTC_2928 9011484 9.79 µM -0.954999796758002 0.176006367932821 no 2782 0.169788899870462 4062 2994751
SGTC_3101 9120531 49.47 µM -0.955611406099954 0.175846109063027 no 2783 0.169634298373653 4047 24824904
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.955734952503756 0.175813747650127 no 2784 0.169603079504933 4012 803109
SGTC_252 miconazole 1.30953 nM -0.95580334459136 0.175795834832791 no 2785 0.169585799133229 3945 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2634 4'-methoxyflavone 100 µM -0.958667289948417 0.17504676659839 no 2786 0.168863190937583 4052 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_986 1493-0483 84 µM -0.95904817951408 0.174947297271377 no 2787 0.168767237133538 3965 40079
SGTC_3280 9140961 49.47 µM -0.960000317719681 0.174698803265044 no 2788 0.16852752751449 4081 4901226
SGTC_2492 derrusnin 100 µM -0.960068737188009 0.174680955428431 no 2789 0.168510310713159 3995 1715307 Part of coumarin class of compounds.
SGTC_1548 st061468 90.8 µM -0.961077573070017 0.174417925862382 no 2790 0.168256582561868 4027 390799
SGTC_2303 7774051 200 µM -0.961146099304212 0.174400068433531 no 2791 0.168239356729503 4067 2953184
SGTC_1801 st050089 28.441 µM -0.96136998300184 0.174341734097296 no 2792 0.168183085709186 4071 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1032 k061-1018 98.7 µM -0.963491637737569 0.173789538837058 no 2793 0.167650429332548 4162 4005393
SGTC_277 nystatin 15.5 µM -0.963797041190257 0.173710144296619 no 2794 0.167573845196185 4032 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2878 9043973 25.97 µM -0.967806441588298 0.172669976735182 no 2795 0.166570523066708 4117 6465167
SGTC_2544 sphondin 68.51 µM -0.971039681503992 0.171834068573762 no 2796 0.165764259344475 4062 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2879 9041815 71.43 µM -0.971053217030454 0.171830574596935 no 2797 0.165760889341315 4059 4942971
SGTC_2229 7354935 190 µM -0.971091877672776 0.171820595228441 no 2798 0.165751264064796 3981 318112
SGTC_989 1501-0895 10.3 µM -0.971276218272237 0.171773016971258 no 2799 0.165705374058313 4021 2830112
SGTC_862 0452-0056 10.2 µM -0.97264791459783 0.171419246836529 no 2800 0.165364160081006 4021 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2969 9091408 28.7 µM -0.973102782631569 0.171302036060676 no 2801 0.165251110602529 4008 4286311
SGTC_3105 9121040 49.47 µM -0.975342059998725 0.170725764412262 no 2802 0.164695306842745 3907 41448907
SGTC_663 1486-0733 13.9 µM -0.977057959091201 0.170285023373396 no 2803 0.164270229682439 4084 722445 YPR165W RHO1
SGTC_185 k048-0037 25.491 µM -0.977093843432567 0.170275814009935 no 2804 0.16426134770839 4107 6827589
SGTC_2398 5228213 48.84 µM -0.977406958126401 0.170195469741152 no 2805 0.164183859804054 4086 80771 YMR134W ERG29
SGTC_444 curcumin 90.4 µM -0.977755417909718 0.170106084594579 no 2806 0.164097652767823 4016 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3259 9138485 49.47 µM -0.978278558370146 0.169971947739625 no 2807 0.163968285829895 4062 17646153
SGTC_2246 7293507 91.5585 µM -0.979720346568098 0.169602614268817 no 2808 0.163612089906696 4104 887656
SGTC_1321 1326-2144 215 µM -0.979839294656342 0.169572167119755 no 2809 0.16358272605502 4082 3513030
SGTC_2787 5284540 71.43 µM -0.982252901727873 0.16895511357078 no 2810 0.16298763564001 4128 736958
SGTC_870 0573-2213 57.6 µM -0.985882415921882 0.168029924790028 no 2811 0.162095408306483 4067 3916321
SGTC_329 k048-0121 21.3 µM -0.986047368640128 0.167987954780264 no 2812 0.162054934421168 4100 6832902
SGTC_1525 8-methoxypsoralen 92.5 µM -0.986571946182826 0.167854527902234 no 2813 0.161926264373917 4145 4114 Related to psoralen; DNA damaging agent.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.988493332820898 0.167366403870025 no 2814 0.161455549043336 3992 107982 A Capsaicinoid.
SGTC_3244 9134489 49.47 µM -0.989071858283554 0.167219610112627 no 2815 0.161313992601967 4091 16584271
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.989393715615109 0.167137978694419 no 2816 0.161235274031649 3901 4000243
SGTC_62 0180-0423 3.232 µM -0.990696228075468 0.166807889963864 no 2817 0.160916966727203 4025 30102 YGL099W LSG1
SGTC_216 k038-0035 28.382 µM -0.992450488987409 0.166363982201078 no 2818 0.160488910090159 4017 4444231 YPR107C YTH1
SGTC_3342 9147791 14.508 µM -0.995072748079003 0.16570185514378 no 2819 0.159850441896591 3978 1838168
SGTC_1796 st049173 110.4 µM -0.998664289030689 0.164797750970365 no 2820 0.158978672735249 4038 94134
SGTC_993 3909-8757 62.7 µM -0.999382342839345 0.164617378175602 no 2821 0.158804755038082 4025 4288324 YLR208W SEC13
SGTC_2854 9024559 71.43 µM -1.00057554052744 0.164317933792752 no 2822 0.158516030049067 4144 3163529
SGTC_2690 usnic acid 100 µM -1.00155682476989 0.164071935940215 no 2823 0.158278841146448 4129 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3200 9114385 49.47 µM -1.00582477144107 0.163004786409589 no 2824 0.157249934529334 4144 17018030 YLR208W SEC13
SGTC_1860 st056228 74.6 µM -1.00735599764294 0.162623023706171 no 2825 0.156881864396081 4069 688679
SGTC_2 0422-0095 29 µM -1.00955790948853 0.162075067275093 no 2826 0.156353571932151 3995 6790840
SGTC_458 nppb 133 µM -1.01078886682159 0.161769262204844 no 2827 0.156058746390781 4126 4549 A chloride channel blocker.
SGTC_1689 st020265 53.493 µM -1.01145252759913 0.161604545964096 no 2828 0.155899945671738 4100 5758320 YPR016C TIF6
SGTC_441 propafenone 146 µM -1.01281454277599 0.161266845308727 no 2829 0.155574376498821 4084 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2856 9022925 19.48 µM -1.01288993935051 0.161248164793496 no 2830 0.155556367195439 4160 4944862
SGTC_2551 apiole 73.87 µM -1.01473766221315 0.160790807810405 no 2831 0.155115448041485 3975 10659 A possible DNA adduct former.
SGTC_2437 5741531 144.16 µM -1.01519657234726 0.160677347667335 no 2832 0.155006067091057 4138 2262990
SGTC_379 3970-0972 5.9 µM -1.0158931496206 0.160505227055543 no 2833 0.154840135679865 4101 2898042 YBL034C STU1
SGTC_3068 9116768 49.47 µM -1.01592216553769 0.160498059987965 no 2834 0.154833226355706 4098 41904888
SGTC_814 3342-0569 96 µM -1.01687818828847 0.160262034818949 no 2835 0.15460569034404 4165 4346283
SGTC_357 1325-0123 420 µM -1.01725495068741 0.16016908117396 no 2836 0.154516080604809 4133 1098503
SGTC_562 3772-2733 112 µM -1.01770506813785 0.16005807581515 no 2837 0.154409069005645 4114 2876874 YIL048W NEO1
SGTC_1911 st060208 74.3 µM -1.01924960090705 0.159677554641046 no 2838 0.154042242074754 4162 688783
SGTC_2423 st077119 87.2 µM -1.02285887065702 0.158790661223659 no 2839 0.153187289192258 4041 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1848 st056003 16.4 µM -1.02322889854859 0.158699918388429 no 2840 0.153099816167483 4133 146492
SGTC_2119 5528445 120.635 µM -1.02366693272659 0.158592542160427 no 2841 0.15299630954578 4134 791935
SGTC_1877 wortmannin 25 µM -1.02632243477069 0.157942613524044 no 2842 0.152369812887461 4121 312145 A covalent inhibitor of PI 3-kinase.
SGTC_733 4069-0007 56.1 µM -1.02734084648495 0.157693823973012 no 2843 0.152129997499663 4114 5717425 YNL287W SEC21
SGTC_1233 0325-0408 14.2 µM -1.02830254010748 0.157459126642447 no 2844 0.151903768293339 4160 12874
SGTC_515 4092-1064 102 µM -1.02860410271661 0.157385578845497 no 2845 0.151832874633661 4160 717353
SGTC_1727 st034309 9.9045 µM -1.0292924880674 0.157217773864547 no 2846 0.151671126085957 4192 870305
SGTC_1708 st033234 31.827 µM -1.02994776183085 0.157058149693864 no 2847 0.151517264135499 4226 674664
SGTC_2493 resveratrol 26.09 µM -1.03151302590106 0.156677284187378 no 2848 0.151150151494581 4041 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1622 st003707 19.4 µM -1.03197526983215 0.156564925755341 no 2849 0.151041851379658 4143 10140899
SGTC_2432 5630864 12.22 µM -1.03215310422686 0.156521713375088 no 2850 0.151000199938308 4177 5714970
SGTC_2877 9040724 71.43 µM -1.03564542103733 0.155674698898691 no 2851 0.1501837967823 4129 6463895
SGTC_1173 0443-0020 122 µM -1.03919945845807 0.154815824190723 no 2852 0.1493559911481 4114 5331295
SGTC_2312 7706453 155.7 µM -1.0417267888334 0.154206973328327 no 2853 0.148769182625549 4136 976098
SGTC_2270 7924575 90.91 µM -1.04874212989926 0.152525240202883 no 2854 0.147148409212364 4136 1262135
SGTC_1653 st012112 65 µM -1.05012199570629 0.152195893393963 no 2855 0.146831013537969 4134 720429
SGTC_1995 st072814 61.1 µM -1.05070011246602 0.152058048763027 no 2856 0.146698172178319 4120 5769371
SGTC_734 2023-0417 80 µM -1.05082828643552 0.152027498533846 no 2857 0.146668730913862 4141 3935732
SGTC_1367 1812-0510 76.9 µM -1.05137548852197 0.151897118928322 no 2858 0.146543084457839 4176 1142582 YDR527W RBA50
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.05319385381856 0.151464398162012 no 2859 0.146126077396735 4223 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_737 1950-0117 57.9 µM -1.05450823158395 0.151152123376477 no 2860 0.14582514696475 4134 5393513
SGTC_1255 0566-0045 221 µM -1.05754102690232 0.150433216008677 no 2861 0.145132370404933 4172 2788469
SGTC_187 1488-2104 32.728 µM -1.05760794342343 0.15041737954544 no 2862 0.145117109787897 4159 2852859
SGTC_1713 st033146 12.748 µM -1.05993244300392 0.149867952920895 no 2863 0.144587667379204 4154 674619
SGTC_2279 7948423 32.93 µM -1.06011049472198 0.149825923270551 no 2864 0.14454716694202 4139 1247112
SGTC_3250 9135583 49.47 µM -1.06045018769036 0.149745759520332 no 2865 0.144469920068565 4199 7699353
SGTC_3110 9122132 49.47 µM -1.06111569677379 0.149588789756877 no 2866 0.144318662591533 4251 918317
SGTC_1229 0139-0193 12.2 µM -1.06325516122556 0.149084910798896 no 2867 0.143833126623757 4240 3090752
SGTC_1456 k015-0012 13 µM -1.0637523060995 0.148967987543021 no 2868 0.143720461168693 4182 2989616
SGTC_2546 rhodinyl acetate 100 µM -1.0649469978337 0.14868725915826 no 2869 0.143449957718806 4114 6708682
SGTC_997 3996-0078 137 µM -1.06535650874126 0.14859111381663 no 2870 0.14335731495213 4202 735687
SGTC_659 k018-0002 107 µM -1.0654797578815 0.148562185411168 no 2871 0.143329440476875 4160 6797879 YHR007C ERG11
SGTC_1654 st012436 41.8 µM -1.06840094720288 0.147877641135527 no 2872 0.142669844974313 4143 4323132
SGTC_1208 2323-2347 50.3 µM -1.06917888799455 0.147695697051331 no 2873 0.142494534955194 4177 5412760
SGTC_2533 agelasine 13.65 µM -1.07031592952356 0.147430036622533 no 2874 0.142238563295645 4234 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_52 0329-0193 875 nM -1.07167780722676 0.147112266724421 no 2875 0.141932386094599 4252 3739292
SGTC_2605 digitonin 300 nM -1.07335624520691 0.146721265300424 no 2876 0.141555654130194 4212 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_808 0711-0032 135 µM -1.07461875148825 0.146427617378763 no 2877 0.141272726528606 4137 4252555
SGTC_617 3770-0098 35 µM -1.07495444485688 0.14634960448392 no 2878 0.141197562219777 4083 5962639
SGTC_2700 st077718 96.8 µM -1.07559214251505 0.146201484683886 no 2879 0.141054851531444 4161 904970
SGTC_469 w7 172 µM -1.07820567896074 0.145595483527962 no 2880 0.140470989081894 4247 45115570 A P450 inhibitor.
SGTC_2818 7996756 12.99 µM -1.07999469161448 0.145181639963433 no 2881 0.140072272022765 4188 2241621
SGTC_2331 7980721 200 µM -1.08011235920296 0.145154448266147 no 2882 0.140046074436995 4137 2981221
SGTC_2220 6782180 200 µM -1.08014029612658 0.14514799285106 no 2883 0.140039855031853 4091 833803
SGTC_2310 7668677 200 µM -1.08068114007687 0.145023057530848 no 2884 0.139919487647824 4193 2197143
SGTC_2344 7990960 76.95 µM -1.08079808638294 0.144996052375714 no 2885 0.139893469941517 4154 140813
SGTC_1388 3346-4487 254 µM -1.08172759414517 0.14478153150696 no 2886 0.139686794020783 4235 3345614
SGTC_206 4546-0025 72.014 µM -1.08293718024977 0.144502691621065 no 2887 0.139418153724341 4231 6620745 YIL048W NEO1
SGTC_2181 6316240 54.2555 µM -1.0833019342334 0.144418677750677 no 2888 0.139337213526073 4200 12779990
SGTC_2233 sulbentine 40.3845 µM -1.086076285242 0.143780738283639 no 2889 0.138722621657557 4178 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1332 1480-0653 17.5 µM -1.08619060257889 0.143754492790155 no 2890 0.138697337025667 4178 5749438
SGTC_1087 pterostilbene 9.05 µM -1.08741834048625 0.143472826930486 no 2891 0.138425984677548 4216 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1829 berberine 14.4 µM -1.08844302313102 0.143238031142455 no 2892 0.138199788397217 4166 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1803 st050068 52.4 µM -1.08949530940932 0.142997180502556 no 2893 0.137967761097308 4241 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_41 0478-0632 82.643 µM -1.08966034052936 0.142959432491651 no 2894 0.137931396139583 4141 3750424
SGTC_152 4469-0003 551.229 µM -1.09512935504904 0.14171229860399 no 2895 0.136729984904249 4139 697280
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.09620006039439 0.141469004110986 no 2896 0.13649561660369 4209 7104
SGTC_1258 0671-0043 57.1 µM -1.09819808318564 0.141015754213159 no 2897 0.136059001531476 4216 4298767
SGTC_792 4534-1957 155 µM -1.09928707509782 0.140769132389534 no 2898 0.135821434090422 4139 1717904
SGTC_3223 9129970 49.47 µM -1.10008664337686 0.140588242193546 no 2899 0.135647186397591 4212 17248386
SGTC_1000 4048-0884 8.67 µM -1.10185358016263 0.140189059335079 no 2900 0.135262666092097 4240 13040088
SGTC_1058 3448-5425 97.3 µM -1.10277920412602 0.139980251801567 no 2901 0.135061530589058 4126 7279705
SGTC_421 streptovitacin 30 mM -1.10587614470853 0.139283163333397 no 2902 0.13439006568972 4256 91467 include heat shock
SGTC_2348 9022543 33.42 µM -1.1101409018479 0.138327083716654 no 2903 0.133469157163633 4243 3162678 YDL140C RPO21
SGTC_1991 st073000 8.92 µM -1.11377221305218 0.137516544966675 no 2904 0.132688460266058 4271 4301969 YIL048W NEO1
SGTC_1624 st003710 6.25 µM -1.11414541784241 0.137433426678118 no 2905 0.132608403444552 4239 24207033
SGTC_3228 9131799 49.47 µM -1.11466683698398 0.137317356287961 no 2906 0.132496608630485 4204 17015818
SGTC_685 1278-0033 54.9 µM -1.11596953465212 0.137027662192541 no 2907 0.132217587733414 4285 3590572
SGTC_304 1310-0298 97 µM -1.11638779419097 0.136934738204105 no 2908 0.132128087949641 4007 1550234
SGTC_137 0438-0332 85.389 µM -1.11761219936197 0.136662961854869 no 2909 0.131866328116433 4158 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2899 9053889 58.44 µM -1.11763784523321 0.136657273288963 no 2910 0.131860849233616 4187 6470052
SGTC_1748 st037455 53.6035 µM -1.11839298505918 0.136489846665647 no 2911 0.131699594522649 4260 580690
SGTC_1470 k295-0292 231 µM -1.12002661879787 0.136128124062438 no 2912 0.131351209482724 4291 5045612
SGTC_1102 cgs 12066b 26.1 µM -1.12238067520209 0.135608038809176 no 2913 0.130850308738729 4222 6438352 A 5-HT1B full agonist.
SGTC_138 0850-0259 40.9225 µM -1.12308085079639 0.135453610958125 no 2914 0.130701579057009 4158 6813004
SGTC_1774 st048371 48.465 µM -1.12718441364716 0.134550969227784 no 2915 0.12983225949182 4198 4242727
SGTC_3126 9127922 49.47 µM -1.12736020024993 0.13451239470513 no 2916 0.129795109601633 4269 45595682
SGTC_297 0986-0032 24 µM -1.13111213543003 0.13369088192307 no 2917 0.129003948590697 4169 2847425
SGTC_1929 genistein trimethyl ether 50.5 µM -1.1327448817451 0.133334459961348 no 2918 0.128660701985077 4209 136420
SGTC_2670 beta-carotene 100 µM -1.13316578231774 0.133242685137667 no 2919 0.128572320348857 4169 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.13557117939732 0.132719036914983 no 2920 0.128068038222729 4252 551469
SGTC_53 0973-0023 39.979 µM -1.13565042501776 0.132701809516159 no 2921 0.128051448097237 4117 674768
SGTC_3038 9091290 49.47 µM -1.136160295985 0.132591004257939 no 2922 0.12794474196118 4258 25236843
SGTC_572 0960-0087 17.7 µM -1.1395537477775 0.131855162538999 no 2923 0.127236132023095 4212 6796365
SGTC_2710 st078562 53.7235 µM -1.13963002991054 0.131838653833897 no 2924 0.127220234467297 4172 17250908
SGTC_1312 1218-2183 165 µM -1.13977830245511 0.131806569302236 no 2925 0.127189337724369 4281 6744073
SGTC_2915 7971052 15.16 µM -1.13986341525653 0.131788154271268 no 2926 0.127171604443946 4139 5741558
SGTC_2103 5378138 10 µM -1.14145742984925 0.131443600699848 no 2927 0.126839808745635 4298 244142
SGTC_2250 alverine citrate 130 µM -1.14290747186145 0.131130708084538 no 2928 0.126538504985162 4115 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_48 0382-0018 55 µM -1.14365939959946 0.130968658526456 no 2929 0.126382458617282 4302 762596
SGTC_2080 5212524 12.4 µM -1.14372896274661 0.130953673819383 no 2930 0.126368029066969 4171 260183
SGTC_2642 cholecalciferol 100 µM -1.14617136572667 0.130428302839932 no 2931 0.125862126666447 4229 9821465 A vitamin D precursor, similar to steriods.
SGTC_1143 3454-2408 5.08 µM -1.14812299111706 0.130009549336805 no 2932 0.125458897105324 4239 X1143
SGTC_2747 doxorubicin 7.63 µM -1.15452979434551 0.12864140984028 no 2933 0.124141515383752 4219 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_201 4262-0159 12.803 µM -1.15479731559459 0.128584500178321 no 2934 0.124086718325872 4282 1341029
SGTC_2725 haloperidol 53.21 µM -1.15851768393165 0.127794878820824 no 2935 0.123326419663061 4185 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2430 5571206 200 µM -1.15910573777057 0.127670377728739 no 2936 0.123206543685545 4255 1731771
SGTC_720 r052-1644 49.9 µM -1.15962269189172 0.127560999328996 no 2937 0.1231012289962 4268 1422863 YOR257W CDC31
SGTC_3216 9129716 49.47 µM -1.16517557522459 0.126390214752632 no 2938 0.121973965109417 4188 8056934
SGTC_1744 st037937 38.9 µM -1.16758278585568 0.125885005697336 no 2939 0.121487548586885 4316 1016152
SGTC_3168 9103419 49.47 µM -1.17082493046617 0.125206794682685 no 2940 0.120834577335269 4271 16649256
SGTC_1291 0993-0025 5.79 µM -1.17385356786208 0.124575555055495 no 2941 0.120226841658458 4258 4353356
SGTC_732 3970-1727 52.7 µM -1.17842152854378 0.123627698002018 no 2942 0.119314299598167 4341 1275699
SGTC_2709 st078560 56 µM -1.17874084977973 0.123561627849674 no 2943 0.119250692042438 4255 17250903
SGTC_3181 9108277 49.47 µM -1.18099941919067 0.123095017528489 no 2944 0.118801477017359 4226 17097298
SGTC_485 niflumic acid 177 µM -1.18132095892765 0.123028689425973 no 2945 0.118737622143843 4316 4488 A COX2 inhibitor.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.18568969648764 0.122129976377164 no 2946 0.117872432509326 4278 616764
SGTC_746 1095-0025 46.6 µM -1.18655137615153 0.121953261948161 no 2947 0.117702312504624 4292 6749286
SGTC_1431 4049-0260 9.09 µM -1.18678409085504 0.121905567319102 no 2948 0.117656397839498 4273 3854841
SGTC_3066 9117245 49.47 µM -1.18716707050153 0.121827104578351 no 2949 0.117580863468311 4320 17176980
SGTC_228 caffeine 993.056 µM -1.19040343353131 0.121165473065296 no 2950 0.116943932094699 4283 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_595 3909-8003 73.7 µM -1.19168319322321 0.120904541743119 no 2951 0.116692745264221 4345 699517
SGTC_3178 9107506 49.47 µM -1.19439499214249 0.120352938029509 no 2952 0.116161747420906 4268 8897194
SGTC_3185 9108267 49.47 µM -1.19612177456902 0.120002620449863 no 2953 0.115824520754358 4283 4910486
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.19715552125918 0.1197932453747 no 2954 0.11562297135615 4284 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3044 9093193 49.47 µM -1.19843372506166 0.119534714278318 no 2955 0.11537410485597 4303 25236277
SGTC_2581 avocatin a 64 µM -1.20002679714339 0.11921304883758 no 2956 0.115064466673813 4237 6710728 A skin care supplement.
SGTC_2616 abietic acid 100 µM -1.20050046079374 0.119117526899198 no 2957 0.114972516894333 4326 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.20287703645241 0.11863906768284 no 2958 0.114511953929068 4280 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2640 pentamidine 10.38 µM -1.20428570890266 0.118356111395655 no 2959 0.114239584195249 4270 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2596 sinensetin 100 µM -1.20602697677319 0.118007007320543 no 2960 0.113903544461997 4302 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2004 4023728 41.89 µM -1.2076657838974 0.117679111387511 no 2961 0.113587922139164 4278 360084 YDR527W RBA50
SGTC_1886 st057356 49.9 µM -1.20898667750456 0.117415293999466 no 2962 0.113333981858976 4270 24207747
SGTC_1784 st039334 36.3 µM -1.20948206701547 0.117316459682208 no 2963 0.113238848286337 4330 3496984
SGTC_1928 4'-methoxychalcone 40.3 µM -1.20953088118739 0.117306724039917 no 2964 0.113229477198473 4313 641818
SGTC_2465 5809242 33.21 µM -1.20977722992621 0.117257600252278 no 2965 0.113182192905381 4338 2731748
SGTC_3129 9127257 49.47 µM -1.21196825255126 0.116821334929463 no 2966 0.112762266769772 4248 837894
SGTC_325 2810-4341 181 µM -1.21494158835845 0.116231141392758 no 2967 0.112194185216699 4292 774970
SGTC_1203 3992-3522 103 µM -1.22044267635716 0.115144785810804 no 2968 0.111148553829174 4412 5322312
SGTC_186 3455-3465 67.277 µM -1.22229733268583 0.114780160418738 no 2969 0.110797603786906 4309 755278
SGTC_280 3448-3607 3.04 µM -1.2223534488075 0.11476914080883 no 2970 0.110786997521194 4265 626179
SGTC_1587 estradiol valerate 56.1 µM -1.22373118223494 0.114498829219258 no 2971 0.110526826227183 4354 13791 A steroid.
SGTC_135 0933-0004 26.348 µM -1.22680835471558 0.113896724527608 no 2972 0.109947314968789 4272 21230617 YGL099W LSG1
SGTC_813 k007-0158 173 µM -1.22761230204352 0.113739790027438 no 2973 0.109796270749048 4312 6523916
SGTC_514 4466-0038 2.65 nM -1.22795849328968 0.113672259277421 no 2974 0.109731274839695 4110 5722064
SGTC_564 3555-0129 330 µM -1.23333598470745 0.112626952516531 no 2975 0.108725218816205 4206 563260
SGTC_3027 9089541 49.47 µM -1.23358304694246 0.112579092676479 no 2976 0.108679156713351 4308 9943819
SGTC_1281 0884-0031 11.8 µM -1.23367957216555 0.112560398169662 no 2977 0.108661164434442 4331 1548255
SGTC_1002 4049-0206 172 µM -1.2343510092773 0.11243041905209 no 2978 0.108536067993678 4278 4662749
SGTC_3252 9135871 49.47 µM -1.2351266229694 0.112280406592576 no 2979 0.108391691260674 4320 17682838
SGTC_3042 9091578 49.47 µM -1.2364326033059 0.112028138517507 no 2980 0.108148901683274 4313 25236497
SGTC_3162 9099653 49.47 µM -1.23822924446329 0.111681755117092 no 2981 0.107815535409206 4292 25237511
SGTC_983 1491-0821 12.2 µM -1.23987746459454 0.11136466099607 no 2982 0.107510360160954 4307 46495113
SGTC_3000 9075062 71.4286 µM -1.24196779737837 0.110963438282212 no 2983 0.10712422184528 4279 17057871
SGTC_3349 9149703 23.001 µM -1.24235064256438 0.110890066525795 no 2984 0.107053608976897 4341 4910494
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.24674155985717 0.110051037549357 no 2985 0.10624613740977 4324 688751
SGTC_2455 5377712 9.75 µM -1.24960753881079 0.109505860528298 no 2986 0.105721473928068 4310 2243908
SGTC_2083 5306046 65.942 µM -1.25002885344429 0.109425880315143 no 2987 0.105644503706682 4322 539837
SGTC_778 3456-2434 196 µM -1.25127921030289 0.109188766016888 no 2988 0.105416313841087 4277 5539063
SGTC_1878 temozolomide 1 mM -1.25565849043071 0.10836120258344 no 2989 0.104619907543853 4264 5394 DNA alkylating agent.
SGTC_1230 0170-0365 3.77 µM -1.2566896751564 0.108166995282169 no 2990 0.104433014131185 4372 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2457 5731572 11.68 µM -1.25803440360255 0.107914113567122 no 2991 0.104189657196067 4383 2865357
SGTC_1814 st052110 31.539 µM -1.25975972311349 0.107590284080704 no 2992 0.103878026703481 4267 674163
SGTC_1021 4476-0760 85.3 µM -1.26053781088575 0.107444472185194 no 2993 0.103737708411005 4348 746768
SGTC_2420 aureobasidin a 50 nM -1.26680732636202 0.106274774319696 no 2994 0.102612095902913 4428 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_154 3389-1638 511.116 µM -1.26829312723428 0.105998922911477 no 2995 0.102346645252924 4340 5238686
SGTC_1272 0839-0021 27 µM -1.26851081755434 0.10595855037052 no 2996 0.102307795054321 4362 5027250
SGTC_1903 st060211 78.3 µM -1.27507642163987 0.104746119771818 no 2997 0.101141096992028 4369 688960
SGTC_1404 3909-7820 48.3 µM -1.27561246201695 0.104647577856785 no 2998 0.101046273305093 4332 23741373
SGTC_2073 5212005 126 µM -1.2761607283489 0.104546857887821 no 2999 0.100949353939634 4228 691789
SGTC_3230 9131665 49.47 µM -1.27958880331803 0.103918690994424 no 3000 0.100344894864581 4332 15943720
SGTC_1179 1021-1431 9.29 µM -1.28022879447237 0.10380172166479 no 3001 0.100232340925429 4364 2840958
SGTC_3067 9117431 49.47 µM -1.28272527143708 0.10334636069136 no 3002 0.0997941714597781 4367 17150885
SGTC_113 0099-0221 2.5 µM -1.28342533401012 0.103218929013046 no 3003 0.0996715514668251 4316 89219
SGTC_1122 capsaicin 818.572 nM -1.28536548731044 0.102866361238787 no 3004 0.0993322978184321 4399 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_781 4335-2806 94.4 µM -1.2900251779901 0.102023170897792 no 3005 0.0985209581650737 4410 845254
SGTC_3009 9080819 71.4286 µM -1.2907217461405 0.101897557351427 no 3006 0.0984000906196841 4368 17027216
SGTC_2102 5377816 72.7585 µM -1.29171739512695 0.101718205441684 no 3007 0.0982275155589026 4414 1379702
SGTC_2886 9058944 51.95 µM -1.29188966300084 0.101687197187686 no 3008 0.09819767901462 4269 4949929
SGTC_318 1488-0629 67.2 µM -1.29275781880254 0.101531033693601 no 3009 0.0980474167263158 4403 3662576
SGTC_1786 berberine 21.6 µM -1.29336568343728 0.101421795271108 no 3010 0.097942306523753 4267 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3320 9137005 35.139 µM -1.29541676721808 0.101053829987216 no 3011 0.0975882484785877 4408 4908713
SGTC_1413 3910-0535 34.4 µM -1.29558780034335 0.101023190584062 no 3012 0.0975587671941329 4393 2876951
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.30009620157148 0.100217981927116 no 3013 0.0967839996886174 4273 17037758
SGTC_2146 5545642 200 µM -1.30140646088029 0.0999848482187937 no 3014 0.0965596816532328 4319 825326
SGTC_652 0437-0092 114 µM -1.30244850051688 0.0997997216072751 no 3015 0.0963815560074832 4307 3091274
SGTC_1064 honokiol 6.76 µM -1.30520485507223 0.0993112407288166 no 3016 0.0959115507137489 4393 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2793 7325131 81.82 µM -1.30663649437133 0.0990582165712027 no 3017 0.0956680980431451 4307 4176441
SGTC_1999 st074831 12.5 µM -1.30732014324922 0.0989375567498999 no 3018 0.0955520029333645 4338 17112523
SGTC_1832 st054113 55 µM -1.31160130736447 0.098184401864066 no 3019 0.0948273458473421 4398 1251267
SGTC_843 0310-0051 143 µM -1.3132808904428 0.097890074660377 no 3020 0.09454415767217 4400 2065037
SGTC_3209 9113616 49.47 µM -1.31483447905886 0.0976184027039788 no 3021 0.0942827684653307 4419 16649353
SGTC_2134 5324836 1.464 µM -1.31539800171687 0.09751999774238 no 3022 0.0941880883828617 4349 699272
SGTC_3338 9144300 39.5675 µM -1.31617111290448 0.0973851118509739 no 3023 0.0940583084928487 4370 4901274
SGTC_256 clotrimazole 625 nM -1.31676997261335 0.0972807219872339 no 3024 0.0939578704051805 4312 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3041 9091929 49.47 µM -1.317111558512 0.0972212154333157 no 3025 0.09390061659686 4380 25236887
SGTC_1196 1588-0294 184 µM -1.31997088711488 0.0967241484864357 no 3026 0.0934223691057739 4402 6144269
SGTC_73 0327-0325 16.231 µM -1.32028185691468 0.0966702020958627 no 3027 0.0933704653864204 4204 53298
SGTC_466 geldanamycin 89.2 µM -1.32757082492295 0.0954120499029498 no 3028 0.0921599640172348 4388 5288382 HSP90 inhibitor.
SGTC_1558 st069300 45.6 µM -1.32773069023382 0.0953845912013568 no 3029 0.0921335455084665 4329 24208000
SGTC_1157 4092-0394 27.6 µM -1.3281104950698 0.0953193786908898 no 3030 0.0920708034223466 4442 3659885
SGTC_2355 9061122 103.12 µM -1.33439082708172 0.0942457999569934 no 3031 0.0910379023462845 4389 5302957
SGTC_431 k089-0097 107 µM -1.33524736651152 0.094100074447172 no 3032 0.090897699421939 4134 5499420
SGTC_835 0312-0010 67.2 µM -1.33588112593909 0.0939923581938285 no 3033 0.0907940654715436 4401 1626196
SGTC_443 clozapine 122 µM -1.3370065359893 0.0938013033541645 no 3034 0.0906102516898862 4368 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_743 1275-0778 158 µM -1.33753979745661 0.0937108745735272 no 3035 0.0905232503450341 4378 2849257 YMR203W TOM40
SGTC_551 k048-0028 34.9 µM -1.3387335842723 0.0935086693590814 no 3036 0.0903287094606017 4367 6836383
SGTC_2075 5212009 200 µM -1.33901528068041 0.0934610022679415 no 3037 0.0902828491972233 4324 780898
SGTC_3103 9120822 49.47 µM -1.33903833270809 0.0934571023272912 no 3038 0.0902790970855046 4404 17141819
SGTC_2593 nobiletin 86.24 µM -1.33915912533683 0.0934366686027695 no 3039 0.090259437912922 4385 72344 An anti-infammatory.
SGTC_2129 girgensonine 121.053 µM -1.34021695426227 0.0932578633540119 no 3040 0.0900874105785376 4393 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_882 0843-0131 351 µM -1.34336621075397 0.09272704013789 no 3041 0.0895767111872742 4384 5425421
SGTC_3012 9080433 71.4286 µM -1.34423419713076 0.0925811301790526 no 3042 0.0894363332948768 4396 17688859
SGTC_351 caspofungin 25 nM -1.34690950054312 0.0921324757612494 no 3043 0.0890046906709671 4397 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_827 3253-0474 693 µM -1.34719597178443 0.092084529459077 no 3044 0.0889585624890638 4415 5402065
SGTC_1234 0326-0494 15.5 µM -1.35038994095729 0.0915512098437914 no 3045 0.0884454678690718 4466 1547813
SGTC_33 0986-0033 35.816 µM -1.35881464884235 0.0901554636508273 no 3046 0.0871026650969514 4365 2848082
SGTC_2767 sibutramine 71.45 µM -1.35881882353308 0.0901547759580637 no 3047 0.087102003494027 4417 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1043 0916-0009 19.3 µM -1.36079703603251 0.0898293451784651 no 3048 0.0867889194267071 4425 3101130
SGTC_2257 7960413 200 µM -1.36533625595978 0.0890859112679545 no 3049 0.0860736943278423 4447 2974689 YIL048W NEO1
SGTC_2372 9071633 200 µM -1.36719254305032 0.0887832111134607 no 3050 0.0857824810330895 4456 21321366
SGTC_83 0170-0301 39.027 µM -1.36812848833188 0.0886308795673855 no 3051 0.0856359304171051 4426 3089716
SGTC_1502 4534-4282 27.7 µM -1.36955403580815 0.0883992360834815 no 3052 0.0854130780428919 4391 3278949
SGTC_958 1222-0007 33 µM -1.37077040294772 0.0882019401709441 no 3053 0.0852232700100178 4472 7312461
SGTC_2239 6685329 187.64 µM -1.37528052242784 0.0874732589424148 no 3054 0.0845222463201443 4448 805680
SGTC_566 0958-0068 16.5 µM -1.37651270588416 0.0872749638006316 no 3055 0.0843314781695969 4324 6815365
SGTC_1827 berberine 7.24 µM -1.37890548516063 0.0868908530778576 no 3056 0.0839619483825578 4319 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_245 methotrexate 289.6 µM -1.37930706906735 0.0868265111341094 no 3057 0.0839000489566138 4378 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_689 0833-0039 98 µM -1.3828808144313 0.0862554914069127 no 3058 0.0833507069787397 4385 5374726
SGTC_1248 0469-0687 58.6 µM -1.38444934087765 0.0860057580700539 no 3059 0.0831104548459013 4389 4017482
SGTC_1930 st074634 34.3 µM -1.38768218685854 0.0854927469746593 no 3060 0.0826169212891844 4337 684253 YOR116C RPO31
SGTC_1619 st003326 88.7 µM -1.38869142750166 0.085333063777477 no 3061 0.0824633010328966 4411 2849032
SGTC_766 1391-0721 126 µM -1.39502919930192 0.0843353978802894 no 3062 0.0815035172777489 4449 1020919 YIL115C NUP159
SGTC_405 ebelactone b 50 µM -1.39541560488878 0.0842748558050622 no 3063 0.0814452741412 4372 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2823 7987624 58.44 µM -1.39818396058209 0.0838420631154253 no 3064 0.0810289160174322 4396 2239440
SGTC_1435 4092-0789 56.7 µM -1.39846977658083 0.083797475129515 no 3065 0.080986021213546 4426 2248285
SGTC_951 1171-0579 82.7 µM -1.39954220403198 0.0836303326424154 no 3066 0.080825225831758 4376 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1380 2291-0730 164 µM -1.40170357700176 0.083294234574944 no 3067 0.0805018910229369 4426 2999191
SGTC_2742 clothiapine 36.27 µM -1.4051805134988 0.0827556957609137 no 3068 0.0799838035803212 4482 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2322 7413319 38.22 µM -1.40717720295143 0.0824476173977214 no 3069 0.0796874249027362 4401 1840400
SGTC_2938 9059746 27.26 µM -1.4073168666405 0.0824261004022429 no 3070 0.0796667250482453 4434 6471769
SGTC_1550 gossypolone 36.6 µM -1.40911202474627 0.0821499094131961 no 3071 0.0794010228796578 4470 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2584 androsterone 48.74 µM -1.40974811194368 0.0820522127545287 no 3072 0.0793070364335594 4348 2754130 A steroid.
SGTC_624 k048-0052 28 µM -1.41346488766482 0.0814831023846154 no 3073 0.0787595391978147 4434 6835531
SGTC_3092 9117248 49.47 µM -1.4170603907653 0.0809353988785881 no 3074 0.0782326358963983 4564 17141857
SGTC_3293 9120939 62.045 µM -1.41818892890914 0.0807640627995277 no 3075 0.0780678066482345 4431 934087
SGTC_2243 6634756 200 µM -1.41986396841388 0.0805102613280008 no 3076 0.0778236437585593 4480 885676
SGTC_393 acivicin 6.25 µM -1.4199950651711 0.0804904230390823 no 3077 0.0778045588631388 4303 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2367 9070478 135.38 µM -1.42145714797612 0.0802694227485329 no 3078 0.0775919514148781 4385 572802
SGTC_253 dyclonine 31.25 µM -1.42741612699837 0.0793734381492906 no 3079 0.0767299925382717 4540 3180 An oral anasthetic.
SGTC_874 0599-0792 117 µM -1.42746981673023 0.0793653999805565 no 3080 0.0767222596184427 4455 765305
SGTC_2736 butenafine 14.65 µM -1.43182595953487 0.0787152702469566 no 3081 0.0760968179828851 4397 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_718 1130-0073 349 µM -1.43373884897205 0.0784310607541862 no 3082 0.0758234007126685 4475 6740020
SGTC_3308 9128332 17.569 µM -1.43438875992215 0.078334676849711 no 3083 0.075730676712418 4426 17332805 YDL196W YDL196W
SGTC_198 3454-2873 16.191 µM -1.43637587677955 0.0780405380816198 no 3084 0.0754477068232962 4468 710957
SGTC_937 3122-0005 46.7 µM -1.43675516687192 0.0779844898253185 no 3085 0.0753937867648006 4454 759535
SGTC_1596 piperlongumine 63 µM -1.43859755485115 0.0777126718604038 no 3086 0.0751322897723305 4498 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2259 7964009 200 µM -1.44083761111449 0.0773831531663208 no 3087 0.0748152825383282 4472 313134
SGTC_2976 9009005 19.48 µM -1.44157928811614 0.0772742845391627 no 3088 0.0747105474247906 4453 2993148
SGTC_130 0136-0219 337.655 µM -1.44407528360013 0.0769087591826454 no 3089 0.0743588998804854 4323 234244
SGTC_1948 st076329 66.6 µM -1.44449522873037 0.0768473898197823 no 3090 0.0742998604470109 4381 24208413
SGTC_1655 st012546 55.1 µM -1.44677707185924 0.0765145795397339 no 3091 0.0739796851820197 4450 720985 YLR208W SEC13
SGTC_941 3237-0776 460 µM -1.4493988696618 0.0761335412466404 no 3092 0.0736131120873979 4487 760008
SGTC_623 k072-0108 16.9 µM -1.45017100184853 0.0760215994052011 no 3093 0.0735054196808703 4430 5382803
SGTC_890 0929-0006 47.2 µM -1.45044747751027 0.0759815471207458 no 3094 0.0734668878059255 4461 1378169
SGTC_490 phenamil 164 µM -1.45092803124357 0.0759119688318697 no 3095 0.0733999507277024 4477 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_467 ro 31-8220 72.8 µM -1.45138305195763 0.0758461321410706 no 3096 0.0733366131867931 4421 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2880 9042983 58.44 µM -1.45813983361578 0.0748736074350132 no 3097 0.0724010018682928 4417 6464714
SGTC_1871 st057448 67.3 µM -1.45927333420661 0.074711395124655 no 3098 0.0722449458445408 4466 691747
SGTC_1342 1486-1464 234 µM -1.46005984553682 0.0745989972335686 no 3099 0.0721368135586011 4479 3253938
SGTC_1712 st032288 53.4 µM -1.46008165624351 0.0745958821733268 no 3100 0.0721338167163536 4283 2883011
SGTC_80 0159-0065 512.242 µM -1.46255554228726 0.0742431993880153 no 3101 0.0717945178867254 4420 1548079
SGTC_2223 6903751 107.57 µM -1.46475306307896 0.0739309851348085 no 3102 0.0714941509562709 4459 5598863
SGTC_133 0724-0033 378.92 µM -1.46905654319806 0.0733224727590971 no 3103 0.0709087266997274 4361 280309
SGTC_3117 9124945 49.47 µM -1.46922070897561 0.0732993357986017 no 3104 0.0708864675294109 4379 17592065
SGTC_3343 9148379 18.9835 µM -1.46977982222878 0.0732205781986468 no 3105 0.0708106978640956 4483 1955036
SGTC_3339 9145883 14.936 µM -1.47202352980145 0.0729051770012029 no 3106 0.0705072618433306 4400 2030670
SGTC_1720 st037298 9.481 µM -1.47214468393341 0.0728881758320221 no 3107 0.0704909056076557 4464 597396
SGTC_1927 st060202 13.8 µM -1.47512848490247 0.0724704257910926 no 3108 0.0700890018023614 4408 688887
SGTC_3314 9135860 59.4275 µM -1.47915382869437 0.0719097629657361 no 3109 0.0695496031746713 4469 25252478
SGTC_1895 st058434 18.3 µM -1.47922292066271 0.0719001687323436 no 3110 0.0695403727889758 4470 5393175
SGTC_1158 4092-0494 91.8 µM -1.48609673408041 0.070950556900921 no 3111 0.0686267680209193 4572 1148199
SGTC_1775 st081588 35.1725 µM -1.48786095443542 0.0707083917420179 no 3112 0.0683937833342877 4477 1426443 YGL099W LSG1
SGTC_2440 5628896 157.78 µM -1.49075089050344 0.0703130786135205 no 3113 0.0680134547843069 4460 5522048
SGTC_3072 9116419 49.47 µM -1.49084005486573 0.070300908940311 no 3114 0.0680017463749706 4505 17170162
SGTC_2965 9082772 38.63 µM -1.4922898960582 0.0701032533638494 no 3115 0.0678115821876041 4483 16459634
SGTC_1794 st048918 76.9 µM -1.49253587654218 0.0700697615187297 no 3116 0.0677793596685494 4466 672303
SGTC_964 1287-0107 19.4 µM -1.49433295424025 0.0698254510380954 no 3117 0.0675443079475415 4473 51516812 YPR165W RHO1
SGTC_373 0844-0104 25.9 µM -1.49970095176432 0.0690995817771079 no 3118 0.0668459419651073 4508 5375804
SGTC_402 epigallocatechin gallate 10 µM -1.49976584205726 0.0690908429149416 no 3119 0.0668375341690353 4442 65064 An antioxidant.
SGTC_1656 st012921 11 µM -1.50338378677064 0.0686049557237575 no 3120 0.0663700525294582 4407 6732821
SGTC_971 1315-0384 26.7 µM -1.50388498201477 0.0685378539386653 no 3121 0.0663054922706314 4514 6769120
SGTC_2525 harmine 47.85 µM -1.51050561738416 0.0676562044356824 no 3122 0.0654572285530823 4491 5280953 A monoamine oxidase inhibitor
SGTC_2572 astragaloside iv 100 µM -1.51069722933719 0.0676308191442713 no 3123 0.0654328043300387 4468 45006101 An anti-inflammatory agent.
SGTC_415 dibenzyl ketone 100 µM -1.51228016464459 0.0674213888364319 no 3124 0.0652313024417896 4477 7593
SGTC_2021 4019055 173 µM -1.51243337639447 0.0674011447857909 no 3125 0.0652118247282204 4287 44827708 YER133W GLC7
SGTC_1603 st002045 67.8 µM -1.51339497021469 0.0672741955111058 no 3126 0.0650896809322986 4493 5887985
SGTC_1330 1469-0054 61.8 µM -1.51355815277228 0.0672526705660496 no 3127 0.0650689707520993 4478 7102664
SGTC_1282 0886-0010 32.4 µM -1.51364943701568 0.0672406318448281 no 3128 0.065057387718167 4522 2836211 YNL267W PIK1
SGTC_1486 3970-0793 4.53 µM -1.51513027716006 0.0670455687921307 no 3129 0.0648697077648502 4536 2844330
SGTC_128 0906-2981 13.371 µM -1.51878014482416 0.0665666602396881 no 3130 0.0644089226424291 4486 6740226
SGTC_1998 st075797 76.8 µM -1.52192107605143 0.0661566541089314 no 3131 0.0640144287648641 4482 24208315
SGTC_116 0155-0182 31.788 µM -1.52303404093486 0.0660118418901565 no 3132 0.0638750945631459 4376 771486
SGTC_2269 7935389 174.42 µM -1.52376843206165 0.0659164219641033 no 3133 0.0637832839787175 4512 97605
SGTC_2474 5321570 43.32 µM -1.52662920869738 0.0655457382316148 no 3134 0.0634266198167996 4511 2841384
SGTC_1433 4060-0023 7.6 µM -1.52786725681044 0.0653858207655243 no 3135 0.0632727496328277 4522 3840627
SGTC_519 k048-0011 62.8 µM -1.52854595354404 0.0652982826889116 no 3136 0.0631885215686624 4527 6836379
SGTC_2543 pimpinellin 60.67 µM -1.53611914264381 0.0643276523171347 no 3137 0.0622545810905124 4375 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2788 5282734 71.43 µM -1.54280265800518 0.0634803957053689 no 3138 0.0614393321911976 4534 743706
SGTC_1209 2323-2347 50.3 µM -1.54469478783229 0.0632421182559341 no 3139 0.0612100531047551 4533 5412760
SGTC_1554 st069299 38.7 µM -1.54618277654556 0.0630552242453438 no 3140 0.0610302159563434 4474 24207999
SGTC_2588 indole-3-carbinol 100 µM -1.54660931873888 0.0630017292002896 no 3141 0.0609787406398936 4493 3712 Induces cell cycle arrest.
SGTC_1855 st056195 39.6 µM -1.54840659352648 0.0627767111223883 no 3142 0.0607622173736276 4441 4028379
SGTC_2607 solasodine 47.35 µM -1.55058218127634 0.062505166860744 no 3143 0.0605009225266485 4477 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_274 sirtinol 40.1 µM -1.55096747448999 0.0624571723836702 no 3144 0.0604547393850788 4553 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2459 5811157 9.22 µM -1.55131349145834 0.0624140948894779 no 3145 0.0604132876023331 4474 2870684 YBR192W RIM2
SGTC_1795 st049545 62.3 µM -1.55391173160191 0.0620913658855355 no 3146 0.0601027364809957 4478 5291882
SGTC_2074 5212007 75.395 µM -1.55413853822739 0.0620632559958776 no 3147 0.0600756871521287 4449 758611
SGTC_2571 chrysanthemic acid 100 µM -1.55701071209185 0.0617081438199966 no 3148 0.0597339710732015 4505 2743 An insecticide.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.55823230376537 0.0615575893503801 no 3149 0.0595890949416259 4532 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2201 6605497 169.863 µM -1.56176065553218 0.0611243498961478 no 3150 0.0591721918413042 4488 670741
SGTC_40 0327-0103 19.753 µM -1.56248245302478 0.0610360160994642 no 3151 0.0590871881875181 4374 409036
SGTC_3247 9135149 49.47 µM -1.56592148011315 0.0606165165164356 no 3152 0.0586835002406201 4572 8934436 YOR116C RPO31
SGTC_1600 coumarin 106 71.1 µM -1.56736523780357 0.060441077584511 no 3153 0.0585146722504463 4583 100336 A hepatotoxic, DNA x-linker.
SGTC_815 1582-0027 36.9 µM -1.56773162260221 0.0603966194229051 no 3154 0.0584718892183375 4542 3128206
SGTC_1040 k898-0338 155 µM -1.56903059332073 0.0602392048374112 no 3155 0.058320405311413 4509 20969351
SGTC_3048 9093155 49.47 µM -1.57070694670618 0.0600365323541948 no 3156 0.0581253674364924 4521 25236002
SGTC_524 r073-0010 27.8 µM -1.57101669680703 0.0599991418295215 no 3157 0.0580893852539256 4462 2772106
SGTC_669 0108-0021 26.2 µM -1.57172820187311 0.0599133237527926 no 3158 0.0580067994047559 4534 17201
SGTC_2583 asiatic acid 100 µM -1.57460112542005 0.0595677839857673 no 3159 0.0576742714628837 4538 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2048 5246248 200 µM -1.57502468393215 0.0595169730193662 no 3160 0.0576253735212016 4543 677046
SGTC_1223 0764-0573 147 µM -1.57541046080122 0.0594707239841078 no 3161 0.0575808656782938 4526 1609797
SGTC_1623 st003709 20.3 µM -1.57889029123029 0.0590548150496083 no 3162 0.0571806116535961 4517 16192618
SGTC_1800 st050079 29.0735 µM -1.57945540752691 0.0589874882903807 no 3163 0.0571158185230754 4356 3645560
SGTC_2164 5685496 200 µM -1.58209421682224 0.0586739029184429 no 3164 0.0568140318255734 4473 759046
SGTC_2958 9077254 16.72 µM -1.58357005475233 0.0584990917951765 no 3165 0.0566457964550292 4543 16457351
SGTC_2948 9070189 9.45 µM -1.58515800829361 0.0583114577391758 no 3166 0.0564652192674219 4480 6473636 YDL196W YDL196W
SGTC_674 0498-0004 451 µM -1.58625797486084 0.0581817620475985 no 3167 0.0563404006415256 4530 4231473
SGTC_2260 7964312 200 µM -1.59308088006902 0.0573823378937917 no 3168 0.0555710240017997 4558 231951
SGTC_774 k060-0086 136 µM -1.59483221218004 0.057178538553896 no 3169 0.0553748808200086 4541 5911235
SGTC_1640 st009078 66.4 µM -1.59638238579831 0.0569986233557529 no 3170 0.0552017231597061 4512 690618
SGTC_934 2950-0684 338 µM -1.59943751296086 0.056645346345805 no 3171 0.0548617113121108 4552 1121253
SGTC_959 1222-0044 107 µM -1.60113021412562 0.0564503562574408 no 3172 0.0546740407145335 4530 6083612
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.60389223335593 0.0561333227107586 no 3173 0.054368904540101 4575 5282309
SGTC_543 3844-1095 191 µM -1.60390649796908 0.0561316890240084 no 3174 0.0543673321501176 4557 4230703
SGTC_1426 4048-4480 71.7 µM -1.61184408031322 0.0552284198737064 no 3175 0.0534979366237115 4556 14224343
SGTC_1951 sophoraflavanone G 9.2 µM -1.61254295415227 0.0551494435673208 no 3176 0.0534219203253803 4492 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3246 9135460 32.98 µM -1.61818729659394 0.0545148696639298 no 3177 0.0528111198548138 4539 41446951
SGTC_2884 9058502 51.95 µM -1.61868753918306 0.0544589088439418 no 3178 0.0527572546453578 4525 6471554
SGTC_2162 5663267 200 µM -1.62224080489006 0.0540627209200449 no 3179 0.0523758989082221 4558 6456493
SGTC_1324 1418-0026 34.4 µM -1.62967849209936 0.0532408085383626 no 3180 0.0515847326865864 4575 1372513
SGTC_271 rotenone 740 µM -1.63022336358769 0.0531809882624163 no 3181 0.0515271488773037 4596 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2601 securinine 100 µM -1.63220342872393 0.0529640496965638 no 3182 0.0513183193654222 4518 442872 A GABA receptor antagonist.
SGTC_1710 st031758 61.5 µM -1.63662658558098 0.052481977871732 no 3183 0.0508542585726264 4588 5394341
SGTC_2524 avocatin b 10.57 µM -1.6398630779442 0.0521314501923228 no 3184 0.0505168196392762 4576 6710748
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.64185203852861 0.0519169604243531 no 3185 0.0503103357390367 4514 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_994 3910-0338 138 µM -1.6443608673123 0.0516474088110578 no 3186 0.0500508416801316 4603 3479481
SGTC_1289 0976-0073 69.1 µM -1.64904708464716 0.0511468969874034 no 3187 0.049568994486401 4610 3391136
SGTC_2442 5158906 48.48 µM -1.64993751208303 0.0510522326161303 no 3188 0.0494778586852081 4562 1893835
SGTC_1310 1188-0297 994 nM -1.65377448449226 0.0506459050903975 no 3189 0.0490866710590607 4462 1588352
SGTC_2986 9022445 71.43 µM -1.65828491794481 0.05017155760593 no 3190 0.0486299858673004 4539 6459286
SGTC_690 glyoxal 20.3 µM -1.66212595904916 0.0497704060860307 no 3191 0.0482437608186384 4368 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2504 purpurogallin 52.29 µM -1.66804809844318 0.0491569266845411 no 3192 0.0476530895125173 4522 5281571 An antioxidant.
SGTC_1569 carminic acid 40.6 µM -1.67161120448135 0.0487907411532434 no 3193 0.0473005069529258 4630 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2545 solidagenone 89.61 µM -1.67764403984629 0.04817571154322 no 3194 0.0467083049750247 4537 6708572 An anti ulcer agent
SGTC_2397 5161689 200 µM -1.67985099067233 0.0479522752149122 no 3195 0.0464931556437938 4583 2259942
SGTC_1409 3909-8004 61.9 µM -1.68081767484025 0.0478546676824193 no 3196 0.0463991672189461 4614 2119279
SGTC_2335 9018011 154.17 µM -1.68610164069903 0.0473239455687708 no 3197 0.0458881120254553 4559 6458208
SGTC_348 k064-0012 10.7 µM -1.69011545646218 0.0469239582815348 no 3198 0.0455029342037153 4546 5066323
SGTC_940 3232-1287 54.8 µM -1.6950101903335 0.0464398593554647 no 3199 0.0450367438389497 4572 1585493 YIL048W NEO1
SGTC_2345 9052315 157.45 µM -1.69701260007473 0.0462429761272233 no 3200 0.0448471391995664 4564 6469265
SGTC_2765 myclobutanil 7.74 µM -1.70056266369529 0.0458955706716849 no 3201 0.0445125700606328 4593 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3256 9138902 49.47 µM -1.7032787826647 0.0456311927435848 no 3202 0.0442579546363607 4692 17228773
SGTC_809 3998-0021 90 µM -1.7036438474976 0.0455957520800105 no 3203 0.0442238222659281 4542 715485
SGTC_2323 6148992 148.28 µM -1.7079421377661 0.0451801341275028 no 3204 0.0438235397127466 4551 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2219 9098279 200 µM -1.70804418457297 0.0451703040036278 no 3205 0.0438140721382705 4551 902349
SGTC_1547 harmine 94.2 µM -1.71315473510944 0.0446802041152961 no 3206 0.0433420382777654 4512 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1731 st035964 63 µM -1.72414664636934 0.0436405941847583 no 3207 0.042340686498602 4511 6739575
SGTC_3263 9137018 49.47 µM -1.72505173248466 0.0435558686597115 no 3208 0.0422590749771456 4558 43844957
SGTC_763 3453-1109 128 µM -1.72925468238686 0.0431641667115606 no 3209 0.0418817617284611 4630 1560353
SGTC_2163 5671233 125 µM -1.72940012596753 0.0431506629194217 no 3210 0.0418687537475825 4547 701023
SGTC_1411 3909-8223 150 µM -1.7298426860766 0.0431095941612191 no 3211 0.0418291927915191 4633 X1411
SGTC_407 eburnamonine 100 µM -1.73111154801905 0.0429920211359222 no 3212 0.0417159355456288 4465 3195
SGTC_438 sphingosine 6.67 µM -1.74383144477557 0.041827653853788 no 3213 0.0405942428079639 4552 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1649 st011737 51.3 µM -1.74767189148614 0.0414811653496021 no 3214 0.0402604293755027 4618 1761035
SGTC_2285 7945142 200 µM -1.75720204502994 0.0406313865321801 no 3215 0.0394416884131852 4618 2970608
SGTC_2395 5646831 180.19 µM -1.75960365156199 0.0404194854647602 no 3216 0.0392375159872841 4571 6808628
SGTC_1648 st011736 69.8 µM -1.76130799251288 0.0402696513033351 no 3217 0.0390931440097659 4603 2855514
SGTC_224 benfluorex 43.875 µM -1.76734801888626 0.0397422814706449 no 3218 0.0385849813056373 4627 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1733 st037357 54.9 µM -1.78781534065889 0.0379968422851043 no 3219 0.0369029025143243 4543 1272339 YGL099W LSG1
SGTC_2306 7482397 179.52 µM -1.7888883810383 0.0379070873813037 no 3220 0.0368163966889242 4597 891448
SGTC_2807 7945238 51.95 µM -1.79222636916486 0.0376289855733816 no 3221 0.0365483561640258 4601 17148797
SGTC_1698 5-fluorocytosine 1.055 µM -1.79260083458237 0.037597891467506 no 3222 0.0365183864399312 4631 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1427 4048-4900 550 nM -1.79689630959159 0.0372427107844874 no 3223 0.0361760413100047 4611 24132586
SGTC_316 k060-0003 58.6 µM -1.7980849843009 0.0371449083785449 no 3224 0.0360817706920031 4662 6152314
SGTC_1467 k284-1082 293 µM -1.79888978248554 0.0370788100035397 no 3225 0.0360180585831327 4603 3334705
SGTC_1269 0831-0796 3.05 µM -1.80817383204291 0.0363232363474744 no 3226 0.0352897249921696 4651 927758
SGTC_848 0368-0089 85.6 µM -1.80935532368227 0.0362279921653716 no 3227 0.0351979095985399 4628 762535
SGTC_1509 1326-1131 80 µM -1.81293374928668 0.0359407695011758 no 3228 0.0349210200666636 4612 768313
SGTC_2490 carminic acid 95.39 µM -1.81518688837418 0.0357608800173697 no 3229 0.0347475969786991 4627 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3265 9137266 49.47 µM -1.81586587099815 0.0357068152882512 no 3230 0.0346954748793891 4619 17224265
SGTC_1212 0520-0165 585 µM -1.82416231186895 0.0350515962463559 no 3231 0.0340637687231738 4650 5403258
SGTC_1783 st039459 87.517 µM -1.82908008862369 0.0346678900771702 no 3232 0.0336938056697853 4666 729761
SGTC_1251 0490-5699 265 µM -1.83334808329436 0.0343376850391625 no 3233 0.033375411512871 4637 3883818
SGTC_3037 9091026 49.47 µM -1.83526458673932 0.0341902527248365 no 3234 0.0332332477510047 4511 25236398 YIL048W NEO1
SGTC_3149 9097855 49.47 µM -1.83693868152091 0.0340618945483817 no 3235 0.0331094740374789 4621 25236625 YMR079W SEC14
SGTC_845 0330-0138 4.51 µM -1.83699100888372 0.0340578888379377 no 3236 0.0331056113585352 4606 9039800
SGTC_567 1080-0542 68.4 µM -1.83844886311892 0.0339464443182757 no 3237 0.0329981452715987 4552 5950415
SGTC_907 3448-6986 75.5 µM -1.83861092817743 0.0339340739280601 no 3238 0.0329862163810962 4640 590582
SGTC_1280 0880-0253 10.1 µM -1.84369493303909 0.0335478915886567 no 3239 0.0326138059437728 4644 6836607
SGTC_538 2922-0838 53.3 µM -1.84532138180498 0.0334251125967722 no 3240 0.0324954009609772 4659 777039
SGTC_1990 st072050 59.8 µM -1.85045066843915 0.0330403289387257 no 3241 0.0321243109673001 4637 17233948
SGTC_12 0849-0099 9.267 µM -1.8579799791639 0.0324821204608915 no 3242 0.0315859287377619 4636 6071388
SGTC_1818 st052136 56.3 µM -1.86591787137325 0.0319020687274697 no 3243 0.031026428419087 4326 674169
SGTC_153 4077-0274 519.67 µM -1.87599746021613 0.0311778711329276 no 3244 0.0303278143230732 4640 3121976
SGTC_735 3076-0345 636 µM -1.87838110021907 0.0310086144527293 no 3245 0.0301645245651351 4643 2888990
SGTC_374 0880-0231 82.3 µM -1.88256274964327 0.0307135225293177 no 3246 0.0298798242699315 4524 6833587
SGTC_2249 haloperidol 116.36 µM -1.88313900949353 0.0306730397368338 no 3247 0.0298407659281061 4582 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2010 4012422 159 µM -1.88558349991356 0.030501802964144 no 3248 0.0296755513015232 4613 952393
SGTC_179 1273-0063 6.77 µM -1.88713961790999 0.0303932098205644 no 3249 0.0295707746145601 4612 3108139
SGTC_2705 st078069 42.8 µM -1.89396434023266 0.0299207254823368 no 3250 0.0291148716437228 4654 1530061
SGTC_2278 7948257 134.34 µM -1.89610650247268 0.0297736830368726 no 3251 0.0289729814707488 4656 1247028
SGTC_618 k072-0232 33.2 µM -1.90112838475337 0.0294313196920606 no 3252 0.0286425992582306 4680 5872756 YGL099W LSG1
SGTC_1061 3448-9325 110 µM -1.90142527269436 0.0294111823131473 no 3253 0.0286231659317665 4634 723482
SGTC_2067 5224629 34.075 µM -1.90535598686783 0.0291456457075466 no 3254 0.0283669061705057 4638 2835000
SGTC_1561 5-methoxyflavone 52.9 µM -1.9112414237023 0.0287517851213098 no 3255 0.0279867813968993 4644 94525
SGTC_1422 4031-0024 15.5 µM -1.91953531157204 0.0282042692952273 no 3256 0.027458310922147 4625 782427
SGTC_411 enrofloxacin 100 µM -1.92034158745762 0.0281515094906017 no 3257 0.0274073832879213 4690 71188 A bacterial gyrase inhibitor.
SGTC_610 4215-0184 155 µM -1.92758120141306 0.0276814464009932 no 3258 0.0269536194844802 4679 5605015
SGTC_3118 9124250 49.47 µM -1.93113530964753 0.0274530853703167 no 3259 0.0267331607079077 4651 1504786
SGTC_468 gf-109203x 121 µM -1.93260400299398 0.0273591776281828 no 3260 0.0266424994670496 4727 2396 A protein kinase C inhibitor.
SGTC_3264 9137442 49.47 µM -1.93446380252157 0.0272406472472634 no 3261 0.0265280642165812 4627 17015726
SGTC_1161 k007-0610 110 µM -1.94396448477818 0.0266418057211753 no 3262 0.0259498670130499 4609 5843850
SGTC_1243 0416-0003 5.65 µM -1.96367623000848 0.0254343782466332 no 3263 0.0247838254342731 4648 2141977
SGTC_3087 9117406 49.47 µM -1.96569187406221 0.025313536122873 no 3264 0.0246671070231105 4661 42546093
SGTC_352 k048-0007 5.11 µM -1.97576578920107 0.0247167702788365 no 3265 0.0240906548939327 4604 6811911
SGTC_3145 9085516 49.47 µM -1.97970411964735 0.0244866995793135 no 3266 0.0238683926994341 4646 25236195
SGTC_2993 9054257 71.4286 µM -1.99323317955688 0.0237100038756947 no 3267 0.0231179597368627 4620 6470217 YGL055W OLE1
SGTC_2833 9001315 45.46 µM -2.00363347065578 0.0231271060653785 no 3268 0.0225546688561281 4626 2989378
SGTC_270 tamoxifen 5.46 µM -2.0060655849175 0.0229925496193902 no 3269 0.0224246255367355 4684 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1073 triclabendazole 3.09 µM -2.01399419917748 0.0225584699493346 no 3270 0.0220050712610743 4711 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1751 st044839 27.194 µM -2.02089584226125 0.0221862600092379 no 3271 0.0216452742031676 4710 5291326
SGTC_1142 3253-1408 9.78 µM -2.03176653272373 0.0216105127342783 no 3272 0.0210886483938849 4687 256655
SGTC_3304 9125678 46.087 µM -2.03687739206193 0.0213442188910923 no 3273 0.0208311651112303 4663 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2190 6049624 200 µM -2.04732095938262 0.0208086922895756 no 3274 0.0203132906540541 4638 2265554
SGTC_1853 st056710 91.2 µM -2.06579511525916 0.0198892237005282 no 3275 0.0194239147687921 4708 269167
SGTC_2724 maprotiline 69.64 µM -2.0670426664975 0.019828394922217 no 3276 0.0193650668739095 4643 4011 A tricyclic antidepressant.
SGTC_3268 9137683 49.47 µM -2.07285485210005 0.0195470784619859 no 3277 0.0190928949021372 4735 1953228
SGTC_1309 pyrazolanthrone 13.4 µM -2.07286672191465 0.0195465074358487 no 3278 0.0190923424098827 4719 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1950 st077106 7.18 µM -2.07373124970712 0.0195049553120155 no 3279 0.0190521386435764 4628 13831864
SGTC_1522 st012842 45.6 µM -2.07426339442775 0.0194794159632888 no 3280 0.0190274277410673 4553 3491067 YOR116C RPO31
SGTC_2981 9013952 38.96 µM -2.08552122725099 0.0189457364816004 no 3281 0.0185110066843053 4638 2996344
SGTC_28 pentachloropyridine N-oxide 1.606 µM -2.08787504650342 0.0188357392896387 no 3282 0.0184045538320147 4710 140250 A respiratory chain inhibitor.
SGTC_2203 7227154 166.4 µM -2.09172058581731 0.0186572010542763 no 3283 0.0182317589528986 4724 896304
SGTC_2139 5578692 56.4705 µM -2.10480373681433 0.0180605333866463 no 3284 0.0176541978840372 4696 650991 YMR113W FOL3
SGTC_2814 7977482 42.97 µM -2.12135131124586 0.017329233494308 no 3285 0.0169461246694337 4686 6456762
SGTC_2522 biochanin a 4.94 µM -2.12652157773133 0.0171059894056065 no 3286 0.0167299272696648 4693 5280373 A possible chelator.
SGTC_3232 9132874 49.47 µM -2.13195385725654 0.016874084461111 no 3287 0.0165053200222784 4697 3784940
SGTC_1745 st081495 74 µM -2.14472055473809 0.0163396335534598 no 3288 0.0159875982261854 4606 13842402 YBL026W LSM2
SGTC_1244 0416-0015 52.5 µM -2.18603813438952 0.0147082024615895 no 3289 0.0144064077423745 4705 96201
SGTC_3287 9117173 37.0625 µM -2.19022654836421 0.0145509271596139 no 3290 0.0142539053812341 4743 2789709
SGTC_1641 st009299 47.1 µM -2.19983870558898 0.0141954530491621 no 3291 0.0139091703823464 4710 4046054
SGTC_417 st075190 100 µM -2.21069603806789 0.0138029522377941 no 3292 0.0135284465410824 4720 222757
SGTC_938 3126-1755 342 µM -2.21118038072582 0.0137856631508219 no 3293 0.0135116742153712 4724 1777771
SGTC_1760 st045453 10.4495 µM -2.21667345669556 0.0135908859716621 no 3294 0.0133227069436206 4727 3323419 YIL048W NEO1
SGTC_2913 7966556 36.57 µM -2.2194637068227 0.0134928602521261 no 3295 0.0132275968459157 4636 2976516
SGTC_1643 st009866 20.2 µM -2.22425196833973 0.0133260634964 no 3296 0.013065748172048 4731 3156273 YOR207C RET1
SGTC_1996 st072960 66.8 µM -2.2247657983896 0.0133082707332293 no 3297 0.0130484822593645 4750 1719405
SGTC_539 4859-0462 2.54 µM -2.23763533602457 0.0128692731990003 no 3298 0.0126224226310293 4714 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2804 7954240 19.48 µM -2.26048194656594 0.0121207501971188 no 3299 0.0118956778278905 4713 828705
SGTC_2036 5160441 105 µM -2.26322481703583 0.012033474352596 no 3300 0.0118109170708936 4710 134534 YIL048W NEO1
SGTC_400 oxethazaine 37.5 µM -2.28938873318258 0.0112279863555398 no 3301 0.0110283880907338 4756 4621 A local anesthetic.
SGTC_887 0885-0007 9.62 µM -2.29248665946994 0.0111357888327617 no 3302 0.0109387882422909 4744 5719458
SGTC_101 0490-5701 117.494 µM -2.29957889690926 0.010927191676811 no 3303 0.0107360444029803 4676 4661669
SGTC_649 1123-0311 367 µM -2.30383176083747 0.0108037439229747 no 3304 0.0106160447446319 4656 693629 YIL048W NEO1
SGTC_775 4577-0580 57.3 µM -2.30766469141434 0.0106935275042071 no 3305 0.0105088966841069 4726 2006902
SGTC_2006 4011487 200 µM -2.30974016513952 0.0106342566236245 no 3306 0.0104512718570167 4685 45595294
SGTC_863 0466-0191 129 µM -2.32160719143539 0.0103008263749274 no 3307 0.0101270481585069 4764 765160 YPR165W RHO1
SGTC_1989 st071868 50.2 µM -2.32346812655396 0.0102493747740681 no 3308 0.0100770089982302 4737 16414057
SGTC_2679 rapamycin 1 nM -2.32416461486638 0.0102301758102637 no 3309 0.0100583365084493 4609 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_384 k007-0144 5.16 µM -2.33470894958997 0.00994332614957956 no 3310 0.00977931521143074 4732 6824886
SGTC_3146 9095609 49.47 µM -2.36381971608504 0.00918754488259897 no 3311 0.00904380609444579 4742 17173999
SGTC_317 4495-0002 170 µM -2.37851010981457 0.00882560402346229 no 3312 0.00869138012660742 4746 15991618
SGTC_1638 st008370 60.6 µM -2.39010494855828 0.0085488171575187 no 3313 0.00842177945902842 4709 24207134
SGTC_1679 SEC14.276 6.7 µM -2.39410491633361 0.00845511433497512 no 3314 0.00833049110750463 4697 1005053 YMR079W SEC14
SGTC_451 chloral hydrate 100 µM -2.4104557008841 0.00808139212787913 no 3315 0.00796630302992949 4738 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_465 cgp-37157 41 µM -2.42051971259554 0.00785865156227155 no 3316 0.00774916948442234 4784 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_103 0844-0104 51.839 µM -2.42730682949027 0.00771150251415916 no 3317 0.00760569250911659 4597 5375804
SGTC_3291 9121177 71.43 µM -2.43217272834836 0.00760750457765111 no 3318 0.00750427402684363 4730 17015612
SGTC_57 miconazole 162.5 nM -2.45663255184129 0.00710321875630382 no 3319 0.00701230264839205 4641 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2838 9002687 71.43 µM -2.46031311203203 0.00702994699121918 no 3320 0.00694079243912175 4729 6457060
SGTC_2553 4-methylesculetin 85.09 µM -2.46413385443544 0.00695459096075144 no 3321 0.00686724046151823 4751 5319502
SGTC_2792 7535235 81.82 µM -2.49220668124738 0.00642244660046681 no 3322 0.00634760698483256 4720 1281891
SGTC_1875 nocodazole 6 µM -2.49600051832025 0.00635336707722118 no 3323 0.00628012090036262 4776 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_570 0987-0065 62.6 µM -2.50119719023342 0.00625981187942778 no 3324 0.00618871199267443 4721 3104428
SGTC_2462 5162487 171.77 µM -2.50633677129984 0.00616848637730859 no 3325 0.00609946840516705 4751 2259986
SGTC_2519 cryptotanshinone 88.04 µM -2.5098250896724 0.00610717653225379 no 3326 0.00603954877125324 4756 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1718 roemerine 11.9335 µM -2.51471828590739 0.0060220849291421 no 3327 0.00595637656397714 4461 235224 An aporphine alkaloid with mutagenic activity.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.523707192188 0.00586850467743231 no 3328 0.0058062303596917 4754 2374 Ca(2+)-ATPase inhibitor.
SGTC_1854 st056233 32.9 µM -2.55385034630018 0.00537854425611383 no 3329 0.00532695183490375 4747 5393174
SGTC_2566 crystal violet carbinol 226 nM -2.56817480448534 0.00515872337328098 no 3330 0.00511177934107934 4696 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1370 2001-0092 44.6 µM -2.61223541906408 0.00453184529783629 no 3331 0.00449761442030903 4719 790957
SGTC_916 4466-0038 42 nM -2.64495536125526 0.00411128749349138 no 3332 0.00408508471700732 4773 5722064 YGL116W CDC20
SGTC_1747 st037496 66.6 µM -2.67119753556898 0.00379960369476389 no 3333 0.00377905769896949 4741 723305
SGTC_462 ag-879 158 µM -2.69902812720694 0.00349235504823831 no 3334 0.00347711492408817 4772 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_359 0081-0058 15.9 µM -2.74562841794546 0.00302754371886218 no 3335 0.00301975627621832 4751 3494159
SGTC_3085 9117376 49.47 µM -2.74716834490874 0.00301318279083353 no 3336 0.00300561355137743 4787 16480349
SGTC_1106 tegaserod maleate 11.7 µM -2.7473703763769 0.00301130326282663 no 3337 0.00300376252464402 4781 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_914 3820-6779 408 µM -2.75961200893714 0.00289936969000568 no 3338 0.00289350225981323 4738 2893481
SGTC_1166 k206-0078 225 µM -2.78393608324791 0.00268802354460325 no 3339 0.00268518079880008 4773 5404595
SGTC_912 3474-0017 2.18 µM -2.78605403715493 0.00267029626471302 no 3340 0.0026676988342858 4772 3360550
SGTC_1734 st037168 69.4 µM -2.86361840908737 0.0020895329218209 no 3341 0.00209416119255497 4772 708907
SGTC_3266 9136860 49.47 µM -2.88955751339642 0.00192254672104405 no 3342 0.00192892214860521 4627 4871271 YPR165W RHO1
SGTC_1168 k815-0004 80.5 µM -2.90318423076322 0.00183976808946416 no 3343 0.00184694634085024 4787 642433
SGTC_3249 9135183 49.47 µM -2.90698654609012 0.00181725552688197 no 3344 0.00182464446378947 4772 4902779
SGTC_512 prima-1 270 µM -2.97888793517981 0.00143607900620595 no 3345 0.00144648281325225 4794 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2910 7948405 25.97 µM -3.00797156596062 0.00130381562042624 no 3346 0.00131498871819735 4786 2971328
SGTC_1754 st042065 16.137 µM -3.0110117901438 0.0012906529600985 no 3347 0.00130189371102387 4690 1126236 YIL048W NEO1
SGTC_3081 9117243 49.47 µM -3.06848691002254 0.00106360422430903 no 3348 0.00107572876901303 4763 45595589
SGTC_2564 betulinic acid 100 µM -3.10195000624315 0.000948909590762117 yes 3349 0.000961252115289874 4761 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_342 k048-0088 23.3 µM -3.17119103131639 0.000746805672583429 yes 3350 0.000759076354010263 4804 6820570
SGTC_2846 9008642 19.48 µM -3.17332655317123 0.000741255266711664 yes 3351 0.00075351458296543 4789 2992898
SGTC_911 3456-4043 236 µM -3.33103788559658 0.0004221264532898 yes 3352 0.000432614129498044 4785 914281
SGTC_702 1488-0190 94 µM -3.438026432754 0.000284208286002626 yes 3353 0.000292985247938551 4804 949357
SGTC_2896 9052656 71.43 µM -3.96950339299102 3.37835041227478e-05 yes 3354 3.6011290669967e-05 4621 6469436
SGTC_3152 9099253 49.47 µM -4.08435034651991 2.05643188580025e-05 yes 3355 2.21001506665145e-05 4757 25236131
SGTC_58 0957-0393 9 µM -4.26544786739746 9.1568451645283e-06 yes 3356 9.97507978301663e-06 4647 6997992