SGTCid condition conc unit LRP1|YHR081W.score LRP1|YHR081W.strain.pval LRP1|YHR081W.strain.significant LRP1|YHR081W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3337 9144342 33.5465 µM 8.8569339755208 9.19554294124005e-17 yes 1 4.1122606786592e-19 5 17682949 SGTC_1483 3453-0561 55.9 µM 4.59329428630184 6.93396007660257e-06 yes 2 2.18151549814933e-06 11 4546991 SGTC_364 0083-0097 67.7 µM 4.58289359896101 7.23971965906555e-06 yes 3 2.2929270787474e-06 16 5207356 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 4.5819569974187 7.26787622093653e-06 yes 4 2.30322317288586e-06 31 2374 Ca(2+)-ATPase inhibitor. SGTC_2259 7964009 200 µM 4.42841915770763 1.36037329647781e-05 yes 5 4.74631429869199e-06 23 313134 SGTC_988 1497-1057 103 µM 4.42477479048316 1.38045194110504e-05 yes 6 4.8271472486422e-06 6 3533044 SGTC_1373 2887-0003 58.5 µM 4.41159123233411 1.45546566539309e-05 yes 7 5.13068501539573e-06 14 776948 SGTC_1521 st012942 49.4 µM 4.26092965239132 2.6385715453829e-05 yes 8 1.01789155157819e-05 25 24207259 SGTC_1845 st056753 3.01 µM 4.21065140512556 3.20516439732069e-05 yes 9 1.27317701035731e-05 28 5375839 SGTC_3034 9090421 49.47 µM 4.10013061988515 4.88090985956296e-05 yes 10 2.06458506866465e-05 8 17173761 SGTC_1167 k781-0610 148 µM 4.05264980958391 5.83016833083302e-05 yes 11 2.53203878723226e-05 22 4525169 SGTC_797 k781-0471 270 µM 4.00327814542212 7.00027303791515e-05 yes 12 3.12353914810246e-05 20 23738129 SGTC_955 1216-0110 33 µM 3.99391185949793 7.24586234481815e-05 yes 13 3.2496015907474e-05 63 3619719 SGTC_1049 3226-0134 66 µM 3.97284360019464 7.82825232252122e-05 yes 14 3.55098414915595e-05 28 5702385 SGTC_1698 5-fluorocytosine 1.055 µM 3.96178057822374 8.15143677061276e-05 yes 15 3.7196446261899e-05 8 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3076 9116187 49.47 µM 3.9430526682298 8.72731650082503e-05 yes 16 4.0225489341666e-05 17 27241210 SGTC_249 wiskostatin 11.211 µM 3.86018015705675 0.000117660001885706 yes 17 5.66517291788028e-05 14 2775510 A n-wasp and actin depolymerizer. SGTC_2268 7933382 153.85 µM 3.69683015687313 0.000208692899214879 yes 18 0.000109154145065036 44 935025 YOR257W CDC31 SGTC_2795 7780010 54.55 µM 3.68576963589007 0.000216785686790422 yes 19 0.000114006265143836 38 953673 SGTC_3043 9092303 49.47 µM 3.60429149055182 0.000286065395298498 yes 20 0.000156502807509395 29 25236084 SGTC_2455 5377712 9.75 µM 3.59535494893999 0.000294806655640969 yes 21 0.000161974793401727 28 2243908 SGTC_118 0083-0097 135.343 µM 3.4718423447332 0.000444047710699985 yes 22 0.000258449899403454 191 5207356 SGTC_1022 4477-0945 21.3 µM 3.46797187029407 0.000449697646713132 yes 23 0.000262201089179282 44 4648966 SGTC_1484 3473-2379 286 µM 3.45144454181162 0.000474581265895421 yes 24 0.000278797167746288 32 671917 SGTC_1076 itraconazole 331 nM 3.42693712983381 0.000513835397117647 yes 25 0.000305215191601648 53 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1426 4048-4480 71.7 µM 3.41540166956087 0.000533333547078502 yes 26 0.000318440097431441 31 14224343 SGTC_1848 st056003 16.4 µM 3.38501495438032 0.000588019069039584 yes 27 0.000355871884032227 34 146492 SGTC_59 0330-0160 1.33 µM 3.35917454397727 0.000638551403090587 yes 28 0.000390878368808849 159 4293482 SGTC_1260 0700-1617 7.75 µM 3.35119637190083 0.000654945026146121 yes 29 0.00040231611028142 52 2853078 SGTC_2469 5655019 90.81 µM 3.33631819791307 0.000686558677790748 yes 30 0.000424479671612914 37 2788239 SGTC_3148 9097893 49.47 µM 3.31765819948265 0.000728196817290072 yes 31 0.000453877467255087 62 17174100 SGTC_18 0111-0177 500 nM 3.26080840897752 0.000869821861496401 yes 32 0.000555475391095421 107 721752 SGTC_341 1486-1430 230 µM 3.13579314315334 0.00127447126288037 no 33 0.000856950227357085 53 2054753 YPL210C SRP72 SGTC_2920 7982904 15.77 µM 3.13328564567323 0.00128411486449917 no 34 0.000864305634336229 51 6456808 SGTC_2695 st077686 51.995 µM 3.1075483096805 0.00138702726580273 no 35 0.000943230751071794 65 2876092 SGTC_1171 0368-0077 21.4 µM 3.09047367549354 0.00145940040753199 no 36 0.000999187590766853 44 3239779 SGTC_1121 fusaric acid 630.51 nM 3.07025423673797 0.00154955156945332 no 37 0.00106938312840975 73 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1638 st008370 60.6 µM 3.06715675502287 0.001563802131859 no 38 0.00108052748051308 67 24207134 SGTC_1129 3453-1384 223 µM 3.06138655505826 0.00159066807109091 no 39 0.00110157230648247 85 1084452 SGTC_1622 st003707 19.4 µM 3.05293176064377 0.00163079366892512 no 40 0.00113308732508389 89 10140899 SGTC_1051 3253-3903 78 µM 3.04596694577332 0.00166453831933141 no 41 0.00115966665566365 58 5509239 SGTC_2582 agaric acid 100 µM 3.01561958253081 0.00181911892796008 no 42 0.0012822739544198 426 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_540 1187-0821 17.3 µM 3.00494967087598 0.00187649715343369 no 43 0.00132812399143912 48 847520 SGTC_2754 granisetron 64.02 µM 2.97832887022623 0.00202689333407981 no 44 0.00144912411854336 92 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_998 3996-0085 177 µM 2.93502132683535 0.00229507357868955 no 45 0.00166762381788622 60 715391 SGTC_1437 4092-1038 11.6 µM 2.92499070415585 0.0023616014325301 no 46 0.0017223325645718 54 3977136 SGTC_1097 itavastatin 7.23 µM 2.91813211614716 0.00240809057309525 no 47 0.00176067558711151 59 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2194 5927483 104.545 µM 2.914159384237 0.00243539591756364 no 48 0.00178323884122476 61 760979 SGTC_1252 0493-0875 34.8 µM 2.89667580967984 0.00255892293888081 no 49 0.00188569629808212 89 3960963 SGTC_1374 2889-5571 141 µM 2.88309405394675 0.00265876037058524 no 50 0.00196894921698161 107 2853281 SGTC_1298 1079-1278 263 µM 2.8724266682186 0.0027396267818243 no 51 0.00203666301332883 59 2840950 SGTC_3030 9087619 49.47 µM 2.85593022599726 0.00286905873443196 no 52 0.00214554711936407 63 25236973 SGTC_26 0302-0163 425.158 µM 2.84138162986891 0.00298775643608625 no 53 0.00224592618709619 51 3100915 SGTC_3288 9119690 36.221 µM 2.83855804918695 0.00301129949556634 no 54 0.00226589377937052 59 17595618 YKL019W RAM2 SGTC_840 0245-0196 390 µM 2.81656238151961 0.0032004975697752 no 55 0.00242703076963507 67 3827528 SGTC_253 dyclonine 31.25 µM 2.80755533686292 0.00328101148381552 no 56 0.00249595512419544 92 3180 An oral anasthetic. SGTC_1471 k673-0312 37 µM 2.80558108497925 0.0032989008648644 no 57 0.00251129713446379 50 24099884 SGTC_2129 girgensonine 121.053 µM 2.79147324333986 0.00342931053710872 no 58 0.00262343477422258 103 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_851 0394-0702 453 µM 2.76287521116434 0.00370796606031995 no 59 0.00286473334264046 65 762646 SGTC_2993 9054257 71.4286 µM 2.75826921790517 0.00375469786843848 no 60 0.00290541598241816 140 6470217 YGL055W OLE1 SGTC_274 sirtinol 40.1 µM 2.74349081750351 0.00390822412009513 no 61 0.00303948741729581 84 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_932 2857-0803 154 µM 2.73728097563803 0.00397439649478998 no 62 0.00309746782790149 85 674898 SGTC_3282 9108498 15.4605 µM 2.73524043466958 0.00399635860877429 no 63 0.00311673632526316 97 16459645 SGTC_2424 5537928 59.2 µM 2.73322427251162 0.00401816500591601 no 64 0.0031358805357102 119 5382802 SGTC_400 oxethazaine 37.5 µM 2.73278377438622 0.00402294350076014 no 65 0.00314007729324979 78 4621 A local anesthetic. SGTC_1934 st074720 32.6 µM 2.73034680417031 0.00404947164337798 no 66 0.00316338652356096 132 17250992 SGTC_1893 st059353 36.1 µM 2.7242105631083 0.00411696383916464 no 67 0.00322276992124527 88 3112488 SGTC_1337 1486-1011 40.3 µM 2.71547167714579 0.00421482002685036 no 68 0.00330907185114599 75 X1337 SGTC_2679 rapamycin 1 nM 2.71226542695989 0.00425124128129612 no 69 0.00334125298260201 260 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_806 3966-4455 5.86 µM 2.70894514505309 0.00428925423820992 no 70 0.00337487492307589 82 714982 SGTC_2730 imipramine 71.33 µM 2.7061527373449 0.00432145864851502 no 71 0.00340338656150003 112 3696 A tricyclic antidepressant. SGTC_2944 9067346 25.62 µM 2.70291184205017 0.00435910624652258 no 72 0.00343674869980884 104 6473075 SGTC_2832 7992762 51.95 µM 2.66417000316316 0.00483237701606005 no 73 0.00385892740405363 102 2985177 SGTC_1163 k060-0048 49.9 µM 2.66251514366129 0.00485357608876495 no 74 0.00387795397972658 108 6809982 SGTC_62 0180-0423 3.232 µM 2.65278304940584 0.0049799315805447 no 75 0.00399155817351929 92 30102 YGL099W LSG1 SGTC_882 0843-0131 351 µM 2.62364153763185 0.00537598895374656 no 76 0.00434976453562831 99 5425421 SGTC_2651 TUB2.036 5 µM 2.6130731437493 0.00552639777421896 no 77 0.00448660479466558 292 15992207 YFL037W TUB2 SGTC_1053 3366-3204 134 µM 2.60891255435143 0.00558662921857956 no 78 0.00454152250335373 114 3632071 YPR165W RHO1 SGTC_2570 licareol 100 µM 2.60420296668357 0.00565551124106937 no 79 0.00460441021500295 116 443158 SGTC_956 1185-0240 191 µM 2.56765074251782 0.00621626031557234 no 80 0.00511951301059266 111 1416193 SGTC_1074 carmofur 3.8 µM 2.56468309072529 0.00626387852199291 no 81 0.0051635039403667 134 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3031 9088762 49.47 µM 2.55996874185474 0.00634018803750633 no 82 0.0052340789180652 109 205253 SGTC_1502 4534-4282 27.7 µM 2.55617070900209 0.00640226279123167 no 83 0.00529155925828148 85 3278949 SGTC_938 3126-1755 342 µM 2.55387996782187 0.00643996195567464 no 84 0.00532649869346336 93 1777771 SGTC_2020 4017018 200 µM 2.55350221494142 0.00644619753611003 no 85 0.00533228001693579 106 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3180 9109287 49.47 µM 2.51784589206553 0.00705936793156244 no 86 0.00590374852440554 100 18891271 SGTC_2332 7982454 138.89 µM 2.50187806335596 0.00735026165231418 no 87 0.00617682324597149 177 2981748 SGTC_2420 aureobasidin a 50 nM 2.50155429915733 0.0073562675288492 no 88 0.00618247397762398 157 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_401 neomycin 50 µM 2.49749540741199 0.00743192843126451 no 89 0.00625370426191053 81 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2630 antimycin a 100 µM 2.49008510655143 0.00757183240283061 no 90 0.00638562546584073 140 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_464 bw-b 70c 158 µM 2.48736782177992 0.00762371201728498 no 91 0.00643461328961776 141 5353454 SGTC_129 0088-0017 176.636 µM 2.46364981178027 0.00808999625592715 no 92 0.00687652038282614 174 182446 SGTC_3131 9127911 49.47 µM 2.46070190877954 0.00814966716311713 no 93 0.00693327617215018 127 45595681 SGTC_3029 9088683 49.47 µM 2.45182658579522 0.00833166101050927 no 94 0.00710665708223056 126 25236615 SGTC_800 3448-7362 155 µM 2.44818340774082 0.00840739362899208 no 95 0.00717892741160397 388 15991913 SGTC_2239 6685329 187.64 µM 2.43045629548315 0.00878458365521994 no 96 0.00753991231045713 131 805680 SGTC_286 k060-0067 22.9 µM 2.42465264564692 0.00891125413217034 no 97 0.00766152000691158 114 5985051 SGTC_355 1311-2252 105 µM 2.42245011260508 0.00895974392533672 no 98 0.00770812115453497 137 5338538 SGTC_561 1550-0330 72.9 µM 2.416832497914 0.00908446634848178 no 99 0.00782810993565093 96 6812934 SGTC_1632 st005650 90 µM 2.39992458418333 0.00946907565066053 no 100 0.00819922497923883 127 2759605 SGTC_3278 9139605 49.47 µM 2.39952253141789 0.00947839201064244 no 101 0.00820823473766235 106 7958859 SGTC_2156 5649887 115 µM 2.39890269668914 0.00949277051412989 no 102 0.0082221418979373 132 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2472 5377652 49.4 µM 2.39298467048919 0.00963101598741501 no 103 0.00835596965489271 190 1610903 SGTC_1399 3562-5772 25 µM 2.376695020455 0.0100206688811716 no 104 0.00873426225304951 104 23847490 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.37579614590335 0.0100425652014288 no 105 0.00875556707798955 209 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_8 0354-0001 70 µM 2.36437773154639 0.0103243697620697 no 106 0.00903019388955331 233 4993152 SGTC_1676 st018489 23.4 µM 2.36326916233186 0.0103520927803842 no 107 0.0090572538868941 169 3696235 SGTC_1787 fluconazole 80 µM 2.33701442158548 0.0110279072910637 no 108 0.0097192171099707 203 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3208 9114115 49.47 µM 2.33647479311955 0.0110421910486662 no 109 0.00973325492437994 162 650895 SGTC_1767 st044992 70.3 µM 2.32520528757053 0.0113441894837068 no 110 0.0100304928783555 159 9600693 SGTC_338 4055-0136 114 µM 2.31756010181227 0.011553127303275 no 111 0.0102366203483081 141 2900563 SGTC_2980 9014342 25.29 µM 2.31505830480245 0.011622221635874 no 112 0.0103048707281245 154 2996599 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.30480930740302 0.0119090358336192 no 113 0.0105886278064414 151 94937 An inhibitor of serotonin biosynthesis. SGTC_1225 1216-0074 20.6 µM 2.29810523781682 0.0120999508723802 no 114 0.0107779001116114 147 4241466 SGTC_2238 6671620 73.2395 µM 2.29715083009111 0.0121273446142101 no 115 0.0108050834792826 145 729941 SGTC_3155 9099265 49.47 µM 2.2650058168592 0.0130819127350269 no 116 0.0117561612811398 145 25236499 SGTC_1847 st056231 15 µM 2.25771361081132 0.0133072822047101 no 117 0.0119817600575544 214 5393180 SGTC_2707 st078556 66.6 µM 2.25305784262957 0.0134529186531241 no 118 0.012127751056497 121 17250899 SGTC_1666 st014829 29 µM 2.25046803758322 0.0135345240773727 no 119 0.012209625124874 175 3858230 SGTC_2978 9011784 42.97 µM 2.24919789529646 0.0135747025148858 no 120 0.0122499541631155 215 2994934 SGTC_2003 4023581 200 µM 2.2425572913835 0.0137864450226842 no 121 0.0124626884705411 176 16641307 SGTC_1135 dihydrocapsaicin 536.708 nM 2.2422284910047 0.0137970027752498 no 122 0.0124733043332126 189 107982 A Capsaicinoid. SGTC_433 pimozide 108 µM 2.22542286892327 0.0143459977000945 no 123 0.0130264318644667 114 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_13 0199-0087 65 µM 2.198547129541 0.0152630466041954 no 124 0.0139550699401622 141 4589825 SGTC_1958 st076513 41.9 µM 2.18959347807802 0.015579540530471 no 125 0.0142768662187919 200 732122 YGL099W LSG1 SGTC_2583 asiatic acid 100 µM 2.16779487999299 0.0163737116562222 no 126 0.0150871482883151 185 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2783 7738165 71.43 µM 2.16089518132044 0.0166321992176934 no 127 0.0153517186115109 152 17201110 SGTC_3218 9131285 49.47 µM 2.148552508462 0.0171033147169583 no 128 0.0158349448955534 244 17156417 SGTC_1336 1486-0901 104 µM 2.13848353185063 0.0174960468316319 no 129 0.0162387596537517 176 5006114 SGTC_841 0251-0215 91.2 µM 2.12050995371521 0.0182162406943841 no 130 0.0169815315048142 249 3888614 SGTC_1150 3909-7983 10.9 µM 2.09301656908629 0.0193667000042443 no 131 0.0181738377487142 223 23965914 SGTC_422 cantharidin 155 µM 2.05157673610957 0.0212170915953839 no 132 0.0201054075003187 282 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2459 5811157 9.22 µM 2.05054959301511 0.0212647926265141 no 133 0.0201554147549712 178 2870684 YBR192W RIM2 SGTC_343 4130-2827 29.8 µM 2.05007779031183 0.0212867337564717 no 134 0.0201784201619902 221 1118244 SGTC_1284 0929-0043 16 µM 2.04274592870317 0.0216301691183218 no 135 0.0205387978415366 216 1239883 SGTC_2688 kanamycin b 96.69 µM 2.02137943908976 0.0226578178208847 no 136 0.0216202507283696 789 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2946 9065502 71.43 µM 2.02120342148765 0.0226664516239128 no 137 0.0216293558397836 100 16489101 SGTC_2310 7668677 200 µM 2.01656389557554 0.0228950258931655 no 138 0.0218705219808636 247 2197143 SGTC_2487 5918373 44.05 µM 2.0155823913731 0.0229436294432362 no 139 0.0219218313015386 216 2876279 SGTC_2479 5617353 43.85 µM 2.01148475823576 0.0231474818624603 no 140 0.0221371393266166 249 2731746 SGTC_1455 4262-0120 131 µM 2.00324155463325 0.0235621933130896 no 141 0.0225756836811304 239 1529587 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.99655692070707 0.0239030666145314 no 142 0.0229366682813328 240 5377381 SGTC_2411 st077133 39.94 µM 1.98817793911553 0.0243361854619806 no 143 0.0233960069706914 271 1403142 YNL221C POP1 SGTC_1500 4488-1866 171 µM 1.98612870961405 0.024443109560366 no 144 0.023509517087069 221 2900003 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.9841063932533 0.0245490157374157 no 145 0.0236219902867345 229 6708514 SGTC_1006 4099-6547 255 µM 1.97506532877929 0.02502720559689 no 146 0.0241303673969272 227 3146833 SGTC_1480 1070-0044 41.2 µM 1.97053635597332 0.0252696675050111 no 147 0.0243884662842456 229 3124987 SGTC_1397 3532-0190 20.1 µM 1.96857457560158 0.0253753021180798 no 148 0.0245009822641249 156 5322280 SGTC_20 0481-0013 4.944 µM 1.96704615237971 0.0254578581889923 no 149 0.0245889451383011 239 182045 SGTC_234 nsc-17383 10.7 µM 1.96511734620683 0.0255623614375751 no 150 0.0247003286955679 251 408974 SGTC_1096 rimcazole 32.2 µM 1.96198257691198 0.0257329702635987 no 151 0.0248822563801065 194 18528119 A dopamine reuptake inhibitor. SGTC_2748 diazoxide 86.69 µM 1.96136809960301 0.0257665244733705 no 152 0.0249180492406573 164 3019 A potassium channel activatior. SGTC_1361 1608-0041 5.61 µM 1.95446959350277 0.026145744501136 no 153 0.025322853702511 225 X1361 SGTC_315 k915-0449 187 µM 1.95401951411029 0.0261706473026234 no 154 0.0253494547234837 308 20970215 YNL149C PGA2 SGTC_2868 9035608 32.47 µM 1.94846478914738 0.0264796253167103 no 155 0.0256796870075811 238 6462614 SGTC_2376 9072922 81.32 µM 1.94613548634268 0.0266100953875049 no 156 0.025819233449254 265 17087968 SGTC_2208 7283366 200 µM 1.94448294044284 0.0267029838968895 no 157 0.0259186203342328 212 898663 SGTC_763 3453-1109 128 µM 1.94110069583261 0.0268939420964376 no 158 0.0261230323452366 239 1560353 SGTC_2306 7482397 179.52 µM 1.93271163134157 0.027372505760569 no 159 0.0266358657690558 237 891448 SGTC_3047 9092122 49.47 µM 1.93160393818332 0.0274362229404246 no 160 0.026704204703179 236 17173831 SGTC_663 1486-0733 13.9 µM 1.92827985876397 0.0276281748552612 no 161 0.0269101628348624 311 722445 YPR165W RHO1 SGTC_2319 6033012 152.6 µM 1.92325351064804 0.0279205507909939 no 162 0.0272241099770634 196 847246 SGTC_680 0417-1641 114 µM 1.9198088284167 0.0281224080828915 no 163 0.0274410256597096 221 2835990 SGTC_3250 9135583 49.47 µM 1.91914997370044 0.0281611548587931 no 164 0.0274826782675178 188 7699353 SGTC_629 3448-6466 76.7 µM 1.90971576137643 0.0287208656183239 no 165 0.0280849102462443 263 573744 SGTC_2088 5278280 127.392 µM 1.90883398432167 0.0287736489190426 no 166 0.0281417556594261 285 791502 SGTC_1750 st081859 2.357 µM 1.90717866057505 0.0288729546557541 no 167 0.028248727923969 475 5291695 SGTC_1237 0330-0133 46.1 µM 1.90489656914197 0.0290103282462 no 168 0.0283967586617955 238 X1237 YHR072W ERG7 SGTC_2878 9043973 25.97 µM 1.90448080060035 0.0290354143969976 no 169 0.0284237974032888 204 6465167 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.89883884887005 0.0293776173920891 no 170 0.0287928337827249 201 616764 SGTC_3179 9107801 49.47 µM 1.89843583646235 0.0294021890440644 no 171 0.0288193462995566 235 4818259 SGTC_3001 9076041 71.4286 µM 1.87188511538952 0.0310589815264448 no 172 0.0306112496359258 228 16004211 SGTC_2715 st079500 56.4 µM 1.87111460854756 0.0311081923682054 no 173 0.0306645985806141 211 28246688 SGTC_3176 9106582 49.47 µM 1.87015370148311 0.0311696540875656 no 174 0.0307312384600828 102 17018027 SGTC_711 k292-0785 179 µM 1.8689065590018 0.0312495738063783 no 175 0.0308179078161124 258 4146315 SGTC_1709 st033179 39.1045 µM 1.86713378159219 0.0313634690150173 no 176 0.0309414539781815 265 573381 SGTC_1193 1488-0126 41.5 µM 1.86511150807199 0.0314938124249592 no 177 0.0310828879092162 287 1384710 SGTC_1508 1080-0625 72.9 µM 1.85832865138736 0.0319342676039084 no 178 0.0315611787488098 232 767111 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.84800422905948 0.0326144552753912 no 179 0.0323008655225701 270 2333 A French combination drug. SGTC_2210 7115885 190.385 µM 1.84025914285056 0.0331325192124279 no 180 0.0328651003432582 259 2927039 SGTC_3348 9149464 3.537 µM 1.83974929505058 0.0331668591082538 no 181 0.0329025263555887 266 1951442 SGTC_2706 st078239 82.5 µM 1.83378447423675 0.0335707913411359 no 182 0.0333429966407138 258 15434492 SGTC_303 1348-1668 34.2 µM 1.83133219271684 0.0337380280460738 no 183 0.0335254876919935 229 5380509 SGTC_2726 cimetidine 79.27 µM 1.82849490863761 0.0339323752865671 no 184 0.0337376545469011 193 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3069 9117009 49.47 µM 1.82600262629822 0.0341038495180286 no 185 0.0339249331220098 162 41904981 SGTC_1844 rapamycin 4 nM 1.81712533941088 0.0347204230238684 no 186 0.0345989618042158 455 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1189 1431-2119 7.28 µM 1.81177159810259 0.035096672802253 no 187 0.0350107476765454 331 3107275 SGTC_285 1486-1325 46 µM 1.81092085583947 0.0351567681282779 no 188 0.0350765518444113 289 22310230 SGTC_1370 2001-0092 44.6 µM 1.80760792079324 0.0353915945743471 no 189 0.0353337722918713 338 790957 SGTC_1965 Pectolinarigenin 58.4 µM 1.80743594680388 0.0354038194161842 no 190 0.0353471666949594 252 5320438 An anti-inflammatory. SGTC_697 0508-1955 564 µM 1.80662870904633 0.0354612485280995 no 191 0.0354100950498389 306 6243113 SGTC_187 1488-2104 32.728 µM 1.79666563727849 0.0361763580573592 no 192 0.0361943586597442 300 2852859 SGTC_335 4077-0256 27.6 µM 1.79621152000525 0.0362092321140888 no 193 0.0362304416358576 299 3121989 SGTC_1019 4262-0212 3.4 µM 1.79595320283036 0.0362279428935543 no 194 0.0362509799831506 356 4677213 SGTC_1862 st057513 3.81 µM 1.79014158598276 0.0366509943087591 no 195 0.0367155764440633 256 5393163 SGTC_1191 1487-1166 10.6 µM 1.78821286162195 0.0367922839820061 no 196 0.0368708360121822 354 3955771 SGTC_2881 9058953 51.95 µM 1.77636168300123 0.0376702544180247 no 197 0.0378366611941542 325 17122249 SGTC_1441 4106-0040 13 µM 1.77586372280516 0.0377075160103492 no 198 0.0378776907823032 275 2904180 SGTC_148 3253-0744 288.01 µM 1.7745786104342 0.0378038180136044 no 199 0.0379837457965027 271 6893655 SGTC_2699 st077704 54.6 µM 1.77064881040618 0.0380995500569885 no 200 0.0383095598993779 311 645852 SGTC_308 4092-1169 104 µM 1.7699825948424 0.0381498718247306 no 201 0.038365020116233 332 2268590 YDL196W YDL196W SGTC_2536 dehydroabietamide 32.04 µM 1.76865961032718 0.0382499625272929 no 202 0.0384753481992794 322 3983547 SGTC_337 1315-0038 354 µM 1.76774921894743 0.0383189626934154 no 203 0.0385514188641292 279 1626437 SGTC_2512 diallyl trisulfide 49.23 µM 1.76594959276716 0.0384556581074167 no 204 0.038702152998633 224 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2589 lobaric acid 100 µM 1.74652624425977 0.039956451703344 no 205 0.0403597754068523 312 73157 A novel microtubule depolymerizer. SGTC_1902 st060212 70.5 µM 1.7372765350167 0.0406877035797724 no 206 0.0411691856517155 310 688944 SGTC_1944 st076371 56.9 µM 1.73322327124133 0.0410115457513533 no 207 0.0415279961669166 316 24208455 SGTC_3254 9136651 49.47 µM 1.72222898715433 0.0419004875515356 no 208 0.0425140228968633 337 16454030 SGTC_782 0083-0095 30.5 µM 1.71713721041447 0.0423174357394523 no 209 0.0429770523725779 368 3591729 An indicator and reagent. SGTC_2195 6536160 144.242 µM 1.71438344195157 0.0425443271879964 no 210 0.0432291637428145 277 3834386 SGTC_879 0831-1030 162 µM 1.71384806335458 0.0425885526906535 no 211 0.0432783168094349 394 1549252 SGTC_406 estrone 100 µM 1.70603247809578 0.0432384093170191 no 212 0.0440010163971764 303 5870 A steroid. SGTC_604 1000-0114 314 µM 1.70247864525051 0.0435365432544264 no 213 0.0443328391449266 339 1572745 SGTC_1984 st072354 53.1 µM 1.70092826482285 0.0436671246881132 no 214 0.0444782291685202 282 5762938 SGTC_1363 1636-0063 10.4 µM 1.69967627084621 0.0437728048976245 no 215 0.0445959175657188 348 6072185 SGTC_989 1501-0895 10.3 µM 1.6907630266472 0.0445311437893226 no 216 0.0454410356839485 285 2830112 SGTC_980 1473-0395 201 µM 1.68217741003824 0.0452715809230602 no 217 0.0462672215990302 270 768876 SGTC_3216 9129716 49.47 µM 1.68155205774149 0.0453258969884175 no 218 0.046327866900983 314 8056934 SGTC_1025 k007-0731 70 µM 1.67933470483602 0.0455189116333503 no 219 0.0465434154651821 324 6256118 SGTC_624 k048-0052 28 µM 1.67638433193524 0.045776757867373 no 220 0.0468314679469324 311 6835531 SGTC_2391 6285546 200 µM 1.66889313610556 0.0464367232372601 no 221 0.0475692800753307 368 846083 SGTC_1063 disulfiram 1.84 µM 1.65664205981978 0.0475324663557813 no 222 0.0487959317650278 356 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3163 9099914 49.47 µM 1.65179632891616 0.0479715473405915 no 223 0.0492880386626249 227 16268368 SGTC_2089 5281248 129.67 µM 1.64959381228789 0.0481721918879675 no 224 0.049513020711192 347 2737878 SGTC_2606 farnesol 9.78 µM 1.64773811702815 0.0483417624543961 no 225 0.0497032113040579 365 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_90 0870-0863 4.608 µM 1.6472216851136 0.0483890380331711 no 226 0.049756244069196 387 1738164 SGTC_1762 st045503 25.4615 µM 1.64688333254956 0.0484200317894214 no 227 0.0497910142077974 362 4645554 SGTC_3236 9132701 49.47 µM 1.6423964471975 0.0488325423194797 no 228 0.0502539353719194 328 24282524 SGTC_2531 methyl deoxycholate 70.07 µM 1.63999992806774 0.0490540188613477 no 229 0.050502590952261 341 16667744 Haematoxylin. SGTC_1850 st056238 17 µM 1.63825043216785 0.0492162062777182 no 230 0.0506847315624189 394 5393177 SGTC_1804 st050076 49.1 µM 1.63784805923172 0.0492535688573632 no 231 0.0507266966562248 352 3895976 SGTC_2008 4012253 172 µM 1.63383390247847 0.0496275470715451 no 232 0.0511468657838051 392 603940 SGTC_1895 st058434 18.3 µM 1.6317132877988 0.0498260265308474 no 233 0.0513699497523938 349 5393175 SGTC_984 1492-0255 2.91 µM 1.6308945421736 0.0499028264528216 no 234 0.0514562867940221 329 1585198 SGTC_3059 1327-0034 3 µM 1.62616237932927 0.0503485639892188 no 235 0.0519575584454184 388 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2017 5132927 60.65 µM 1.62462698728986 0.0504938672828687 no 236 0.0521210315890131 378 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1679 SEC14.276 6.7 µM 1.61661463726746 0.0512575521141784 no 237 0.0529807451728941 433 1005053 YMR079W SEC14 SGTC_1000 4048-0884 8.67 µM 1.61561887292577 0.0513531004646625 no 238 0.0530883704432964 372 13040088 SGTC_2248 tofa 1.1 µM 1.60759567391878 0.0521281436558495 no 239 0.0539618801562167 326 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2779 methotrexate 400 µM 1.60460476847313 0.0524194323375767 no 240 0.0542904056824896 375 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_459 nigericin 15.3 µM 1.60449082094202 0.0524305553567474 no 241 0.0543029530733439 407 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3318 9139014 38.6185 µM 1.60278900670235 0.0525969014788078 no 242 0.0544906223657069 335 16643984 SGTC_2260 7964312 200 µM 1.59396493739015 0.0534661485338763 no 243 0.0554719441815884 335 231951 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.59338543658366 0.053523630348611 no 244 0.0555368753812123 396 16486 A toxic proline analog. SGTC_2178 5812956 200 µM 1.58469728924831 0.0543913074894264 no 245 0.056517564039381 345 5403383 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.58256677120628 0.0546057701233785 no 246 0.0567601211013422 378 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_615 k087-0205 167 µM 1.5794508022907 0.0549206338883952 no 247 0.0571163463005022 351 9642773 SGTC_1634 st006576 41 µM 1.57550426118331 0.055321483144917 no 248 0.0575700478293642 360 3915356 SGTC_1664 st014217 9.02 µM 1.56743798804078 0.056147957385638 no 249 0.0585061751946579 385 3982782 SGTC_3052 9092717 49.47 µM 1.56149810033439 0.0567627623102242 no 250 0.059203135857762 388 25237534 SGTC_411 enrofloxacin 100 µM 1.55744202081103 0.0571856226429655 no 251 0.0596827880131388 358 71188 A bacterial gyrase inhibitor. SGTC_3005 9076496 71.4286 µM 1.55367858613541 0.0575801875413372 no 252 0.0601305517287489 348 21368410 SGTC_2814 7977482 42.97 µM 1.55302686222408 0.0576487323759042 no 253 0.0602083586331144 473 6456762 SGTC_1037 k284-1091 78.7 µM 1.54695300193217 0.0582906382740655 no 254 0.060937289483573 329 3334711 SGTC_1166 k206-0078 225 µM 1.54664607455755 0.0583232238126824 no 255 0.060974306518915 429 5404595 SGTC_412 gemfibrozil 100 µM 1.54585211649647 0.0584075822842362 no 256 0.0610701435360669 322 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2104 5389443 200 µM 1.54027688063425 0.0590026558737814 no 257 0.0617464383759489 443 2244536 SGTC_1047 2043-3044 82 µM 1.5382482983774 0.0592203532828881 no 258 0.0619939579025516 419 669592 SGTC_512 prima-1 270 µM 1.53483808977209 0.059587738898429 no 259 0.0624118019938503 404 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1863 st057641 20.1 µM 1.53054517063635 0.0600527566099021 no 260 0.0629409207602809 423 3921635 SGTC_2603 homopterocarpin 100 µM 1.52682371101096 0.0604581678070516 no 261 0.0634024269292928 460 101795 A weak amylase inhibitor. SGTC_2721 ifenprodil 61.44 µM 1.51850376770228 0.061372276363818 no 262 0.0644437252074643 404 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2173 5763948 167 µM 1.51627729516897 0.0616187201532401 no 263 0.0647246251450168 428 2867177 SGTC_1072 oxiconazole 14.9 nM 1.51478561217336 0.061784263381706 no 264 0.0649133526273758 452 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2664 lyso-paf C-16 73.48 µM 1.50923081432719 0.0624037760244886 no 265 0.0656199040694106 428 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_765 1319-0117 244 µM 1.50622698198655 0.0627407979830426 no 266 0.0660044575727159 378 3487746 YGL099W LSG1 SGTC_750 4073-0104 132 µM 1.50512160828833 0.0628651743748115 no 267 0.0661464072678193 321 22330957 SGTC_791 1348-1292 225 µM 1.50468532284185 0.0629143179538662 no 268 0.0662024991432672 506 5437054 SGTC_1016 4226-1401 38 µM 1.498189152362 0.063649597982461 no 269 0.0670420565937893 425 2901613 SGTC_1010 4112-3296 15.2 µM 1.4975415941566 0.0637232578958545 no 270 0.0671261955634346 451 704384 SGTC_504 lovastatin 124 µM 1.48693541838112 0.0649391735410846 no 271 0.0685159343258699 348 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_225 nsc-122657 1.016 µM 1.47802496668206 0.0659745438040376 no 272 0.0697005478772743 280 275685 SGTC_2389 9091542 195.52 µM 1.47758582498804 0.0660258997105633 no 273 0.0697593353750106 470 3626624 YOL127W RPL25 SGTC_928 2764-0428 58.7 µM 1.47563496131108 0.0662544201128723 no 274 0.0700209571861858 481 662578 SGTC_3106 9121286 49.47 µM 1.47427793770525 0.0664137401423283 no 275 0.0702033864218973 378 15943471 SGTC_21 0849-0113 22.993 µM 1.47231910111641 0.0666442383538927 no 276 0.0704673637943765 458 1560156 SGTC_2061 5245884 80.95 µM 1.46939084172195 0.0669899634445268 no 277 0.0708634049646323 456 573863 SGTC_334 1502-1024 68.5 µM 1.46786776368885 0.0671703333047109 no 278 0.0710700730703014 448 3296216 SGTC_2307 7538926 6.34 µM 1.46740539499945 0.0672251633541755 no 279 0.0711329038775439 470 96582 SGTC_25 0118-0223 35.662 µM 1.46373229593626 0.0676619683889181 no 280 0.0716335538042656 440 5333628 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.45173427828884 0.0691040609687732 no 281 0.0732877521137456 457 3256 An antibiotic and ribosome inhibitor. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.45170158466644 0.0691080226599662 no 282 0.0732922992562554 417 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2943 9068529 45.32 µM 1.45034731396438 0.0692722819599741 no 283 0.0734808456196272 493 3270634 SGTC_952 1185-0122 232 µM 1.44882432004529 0.0694573648069913 no 284 0.0736933250983461 467 678600 SGTC_2193 5925765 200 µM 1.44731515520807 0.0696411424972724 no 285 0.0739043382110877 369 877370 SGTC_37 0566-0070 1.56 µM 1.44693323415494 0.0696877100211302 no 286 0.0739578119769594 506 1626686 SGTC_2192 5915882 198.485 µM 1.44278600087291 0.0701949255861445 no 287 0.0745403819484401 388 2876149 SGTC_1164 k060-0068 93.7 µM 1.44247525689439 0.0702330442936118 no 288 0.0745841734275854 494 5963676 SGTC_1454 4239-0054 42.6 µM 1.44200547127144 0.0702907027329358 no 289 0.0746504150704914 508 1340767 SGTC_1378 2093-0007 380 nM 1.44022790698525 0.070509198924902 no 290 0.0749014651101316 468 3618014 SGTC_1805 st050013 60.3 µM 1.43564683224177 0.0710747059462617 no 291 0.0755514306660888 398 4037144 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.4323472483428 0.0714841735611631 no 292 0.0760222337089292 497 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_731 3966-0296 387 µM 1.42575377027756 0.0723078227372665 no 293 0.0769697147648973 456 660956 SGTC_3083 9117465 49.47 µM 1.4226085906234 0.0727032676418103 no 294 0.0774248261377499 475 16420915 SGTC_2806 7952793 58.44 µM 1.42197802598815 0.0727827477498441 no 295 0.0775163150713525 469 2972490 SGTC_923 1900-2434 73.3 µM 1.4169228021162 0.0734223446160532 no 296 0.0782527495185692 459 5910570 SGTC_2540 epiandrosterone 100 µM 1.4165917514954 0.0734643792901433 no 297 0.0783011607662736 619 441302 A steroid. SGTC_3190 9110366 49.47 µM 1.41358052143979 0.0738475713182816 no 298 0.0787425518922464 391 17123768 SGTC_3167 9103034 49.47 µM 1.41217646349081 0.0740267650909814 no 299 0.078949004439235 376 5127859 SGTC_33 0986-0033 35.816 µM 1.41214757811355 0.074030455089664 no 300 0.0789532560425828 424 2848082 SGTC_2959 9079155 11 µM 1.40454481944095 0.0750065734711191 no 301 0.0800783375591183 418 16189457 SGTC_1985 st071382 65.5 µM 1.40250211294114 0.0752705023265511 no 302 0.0803826799941441 461 6123237 SGTC_2560 caryophyllene 100 µM 1.40188507154276 0.0753503665218407 no 303 0.0804747845275738 530 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3151 9099821 49.47 µM 1.40140338479947 0.0754127565275482 no 304 0.0805467403387919 428 17174189 SGTC_188 3229-0966 278.469 µM 1.39564841106404 0.076161212154112 no 305 0.0814101982891536 575 5722370 SGTC_1768 st044301 37.178 µM 1.39383013156992 0.0763988577393353 no 306 0.0816844534123141 497 3931349 SGTC_2703 st077852 53.4 µM 1.39152890890068 0.0767004314027915 no 307 0.0820325497963546 464 6281836 SGTC_767 0929-0023 86 µM 1.38573374657583 0.0774638930948663 no 308 0.0829141097829989 593 1204563 SGTC_3036 9090181 49.47 µM 1.38131319273789 0.0780501319711909 no 309 0.0835913417714463 459 25236586 SGTC_2892 9047358 58.44 µM 1.38014342336679 0.078205824587973 no 310 0.0837712448184085 430 6466771 SGTC_1892 st058411 7.36 µM 1.37829453933138 0.0784523854467861 no 311 0.0840561842417522 559 3934738 SGTC_890 0929-0006 47.2 µM 1.37692455458173 0.0786354617268191 no 312 0.0842677873506458 455 1378169 SGTC_2241 6772625 37.8075 µM 1.37046710985042 0.0795027569187575 no 313 0.0852705677842622 481 2285411 SGTC_2732 terfenadine 20 µM 1.37003230000903 0.0795614150398597 no 314 0.0853384095579328 422 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1660 st012960 28.1 µM 1.36776961097492 0.0798671923454869 no 315 0.0856921013759222 502 24207266 SGTC_3118 9124250 49.47 µM 1.36750870144727 0.0799025084441147 no 316 0.0857329558666877 452 1504786 SGTC_1860 st056228 74.6 µM 1.36633726516742 0.0800612168501713 no 317 0.0859165648048569 477 688679 SGTC_1514 1189-1591 158 µM 1.36581707142191 0.0801317700505859 no 318 0.0859981933804217 558 767698 YMR146C TIF34 SGTC_2064 5220758 200 µM 1.3561764666016 0.0814478338299187 no 319 0.0875215139115242 553 788518 SGTC_3124 9127567 49.47 µM 1.35518237025144 0.081584462258577 no 320 0.087679730086229 477 17592030 SGTC_644 1498-1197 63.3 µM 1.35206632594741 0.0820138507100533 no 321 0.088177049245101 552 6741615 SGTC_1020 4335-0961 93.3 µM 1.35074494815425 0.0821964488015991 no 322 0.0883885742425817 480 669075 SGTC_2964 9083345 53.42 µM 1.3494337671772 0.0823779403299212 no 323 0.0885988404554407 471 17741579 SGTC_483 fpl-64176 144 µM 1.34376178394805 0.0831665241065579 no 324 0.0895127155315427 429 3423 SGTC_2383 9036125 200 µM 1.34239961080694 0.0833567515258108 no 325 0.0897332304280452 460 79580 SGTC_1722 st034304 3.6505 µM 1.34088250247422 0.0835690004188254 no 326 0.0899793020329322 535 4036148 YLR033W RSC58 SGTC_1461 k072-0203 53.8 µM 1.33706001164776 0.0841055809056526 no 327 0.0906015243636712 493 5418714 SGTC_2065 5221596 34.26 µM 1.33411428753917 0.0845208471206999 no 328 0.0910832020434642 525 788581 SGTC_1331 1472-0049 76.2 µM 1.32639319287959 0.0856166068037415 no 329 0.0923547461844858 488 24051409 SGTC_1670 st016595 4.04 µM 1.32444617247411 0.0858945953726872 no 330 0.0926774543506551 535 597879 SGTC_2751 anetholtrithion 17.25 µM 1.3239675820483 0.0859630301063819 no 331 0.0927569056873977 531 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2928 9011484 9.79 µM 1.32327160561896 0.086062622155601 no 332 0.0928725353894319 480 2994751 SGTC_880 0833-0487 87.2 µM 1.31585862759873 0.0871287579104414 no 333 0.0941107485813672 529 76075 SGTC_983 1491-0821 12.2 µM 1.31420345135024 0.0873681469341468 no 334 0.0943888736804996 496 46495113 SGTC_708 3448-5400 146 µM 1.31175536903624 0.0877231140129209 no 335 0.0948013440822382 575 3462195 SGTC_1160 4092-0570 10.5 µM 1.31045422146839 0.087912215167515 no 336 0.0950211105613463 580 4994975 SGTC_2855 9016525 58.44 µM 1.30987296978997 0.0879967890463579 no 337 0.0951194063316448 531 43811474 SGTC_1002 4049-0206 172 µM 1.30877662186192 0.0881564761013202 no 338 0.095305014097582 589 4662749 SGTC_832 4083-0019 164 µM 1.30835483176429 0.0882179688669399 no 339 0.0953764926281412 744 1990758 SGTC_1401 3807-4679 7.6 µM 1.30800817789619 0.0882685314555351 no 340 0.0954352677595018 504 3291456 SGTC_2122 5258151 111.688 µM 1.30673033010182 0.088455103628664 no 341 0.0956521570113269 536 2173356 SGTC_1075 aripiprazole 15.2 µM 1.29976711259368 0.0894769337256439 no 342 0.0968404002141728 593 60795 An atypical antipschotic. YIL048W NEO1 SGTC_197 4544-0043 41.561 µM 1.29750340264655 0.0898110097823559 no 343 0.0972290175562781 594 896523 SGTC_1386 3228-0095 33.8 µM 1.29274385151902 0.0905164420943559 no 344 0.0980498328798077 524 870181 SGTC_179 1273-0063 6.77 µM 1.29064508517953 0.0908288123776491 no 345 0.0984133874039648 495 3108139 SGTC_2199 6590217 200 µM 1.28480394275726 0.0917023898402098 no 346 0.099430402121597 469 703109 SGTC_2236 dapsone 200 µM 1.28451222917867 0.0917461799697737 no 347 0.0994813937105072 576 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1335 1486-0900 202 µM 1.28302312617341 0.091969955740179 no 348 0.0997419870248024 593 X1335 SGTC_1838 st055369 84.5 µM 1.28195608697726 0.0921305540454945 no 349 0.0999290255639714 497 676036 SGTC_3274 9138298 49.47 µM 1.2790423509544 0.0925701530097389 no 350 0.100441071306319 583 17015756 SGTC_814 3342-0569 96 µM 1.27687456692809 0.0928982145449782 no 351 0.100823267249789 593 4346283 SGTC_1669 st015249 58.4 µM 1.27445237586286 0.0932657926753683 no 352 0.101251570204118 540 722793 SGTC_302 1094-0063 18.9 µM 1.27280866023988 0.0935158450852185 no 353 0.101542973665024 494 5440289 SGTC_3000 9075062 71.4286 µM 1.27214058337984 0.0936176185535867 no 354 0.101661586994874 535 17057871 SGTC_2785 7756463 72.73 µM 1.27153167994087 0.0937104488838178 no 355 0.101769782259656 547 2201551 SGTC_2265 7929201 200 µM 1.27122079606544 0.0937578708611795 no 356 0.101825055127452 558 1265108 SGTC_3322 9139058 2.11 µM 1.27111809094457 0.0937735413105282 no 357 0.101843320144034 565 4908926 YPR165W RHO1 SGTC_57 miconazole 162.5 nM 1.2589096041881 0.0956500790738122 no 358 0.104031492211579 547 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_518 1021-0119 62.6 µM 1.25547212087316 0.0961833984564033 no 359 0.104653711266039 567 1097762 SGTC_3273 9137859 49.47 µM 1.2523376706413 0.0966716053121481 no 360 0.105223423870123 544 2377234 SGTC_2320 7373003 200 µM 1.24970166910332 0.0970835831507194 no 361 0.105704273692739 550 5415828 SGTC_448 monastrol 171 µM 1.24929946680558 0.0971465560543283 no 362 0.105777781441513 581 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1292 0kpi-0043 232 µM 1.24805926114681 0.0973409240558096 no 363 0.106004677931971 558 3333905 SGTC_1364 1653-0028 37.6 µM 1.24590035391766 0.0976799534935053 no 364 0.106400490075871 602 5718652 SGTC_1122 capsaicin 818.572 nM 1.24055553892033 0.0985230133019876 no 365 0.107384992601463 592 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1355 1499-0035 1.68 µM 1.23947021518452 0.098694854676739 no 366 0.107585706222479 573 1548538 SGTC_772 k072-0172 35.3 µM 1.23705886975755 0.0990774325086492 no 367 0.108032613972083 542 5861980 SGTC_3321 9137793 26.8275 µM 1.23387978264141 0.0995834744313075 no 368 0.108623852079109 622 4904192 SGTC_2427 5545055 42.75 µM 1.22823215803697 0.100487107589848 no 369 0.109679915016798 661 5372858 SGTC_1506 4226-2149 212 µM 1.22099873301447 0.101653191472758 no 370 0.111043249751328 662 991114 SGTC_3114 9122766 49.47 µM 1.21998797596899 0.101816914689614 no 371 0.111234716537362 561 17176985 SGTC_1947 st076332 61.6 µM 1.21751950556444 0.102217566081741 no 372 0.111703309832688 538 24208416 SGTC_2774 tamoxifen 10.92 µM 1.21748194450697 0.102223671370322 no 373 0.111710450992967 590 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.21727686252689 0.102257010697359 no 374 0.111749447222531 599 2724278 An inhibitor of dopamine biosynthesis. SGTC_319 1348-1596 45.5 µM 1.21573081516188 0.102508599778868 no 375 0.112043740727461 636 5380505 SGTC_911 3456-4043 236 µM 1.21393556660497 0.102801305830114 no 376 0.112386164973233 644 914281 SGTC_1913 st060213 96.1 µM 1.21289192462168 0.102971745206756 no 377 0.112585571743661 653 688959 SGTC_1165 k072-0275 30.3 µM 1.21241134636468 0.103050298447772 no 378 0.112677479879776 583 6153523 YGL055W OLE1 SGTC_1132 3456-3614 2.5 µM 1.2120166307089 0.103114849508771 no 379 0.112753007297556 711 3125502 SGTC_2997 9067075 71.4286 µM 1.21143492416418 0.10321003423239 no 380 0.112864380628016 651 27209819 SGTC_87 0100-0052 35.5 µM 1.21053619596594 0.103357218661582 no 381 0.113036605173091 829 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.21050168222346 0.103362874002736 no 382 0.113043222827534 562 2346 DNA damaging agent; causes G2/M arrest. SGTC_1404 3909-7820 48.3 µM 1.2062646353361 0.104058854142574 no 383 0.113857734450947 609 23741373 SGTC_2985 9022375 71.43 µM 1.20532099429806 0.104214318816955 no 384 0.114039703964486 620 4939335 SGTC_802 4112-3352 742 µM 1.20525405436549 0.104225353549382 no 385 0.114052620368689 675 704594 SGTC_1931 st074438 57.1 µM 1.20512593150429 0.104246476361031 no 386 0.114077345239792 585 2787313 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.20318200853859 0.104567339487827 no 387 0.114452947777388 652 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_318 1488-0629 67.2 µM 1.20150495062726 0.104844728316069 no 388 0.114777693632287 578 3662576 SGTC_3032 9089427 49.47 µM 1.19786064547378 0.105449339872058 no 389 0.115485636431327 577 17173707 SGTC_2183 6420625 130.508 µM 1.19682611190294 0.105621433712349 no 390 0.115687169171576 690 2897619 SGTC_3117 9124945 49.47 µM 1.19542866113238 0.10585422085083 no 391 0.115959796595918 530 17592065 SGTC_553 k007-0256 45.7 µM 1.19060196666582 0.106661102785722 no 392 0.116904939601766 637 6287000 SGTC_576 1073-0113 22.7 µM 1.18942508610632 0.106858514142686 no 393 0.117136217039189 805 5439563 SGTC_2711 st079103 59.1 µM 1.18349378158143 0.107857451011335 no 394 0.118306754774987 605 54693780 SGTC_409 arachidonic acid 100 µM 1.18231006034207 0.108057613137572 no 395 0.118541347602102 637 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1180 1193-0155 285 µM 1.18064382221064 0.108339819759867 no 396 0.118872123592384 596 2921347 SGTC_2269 7935389 174.42 µM 1.17915485938261 0.108592450099178 no 397 0.119168258566434 626 97605 SGTC_627 1391-0720 175 µM 1.17767025903054 0.10884476185996 no 398 0.119464044002841 629 997839 SGTC_1248 0469-0687 58.6 µM 1.17677830684234 0.108996554038204 no 399 0.119642001635626 651 4017482 SGTC_2401 5128683 200 µM 1.17675675345417 0.109000223869734 no 400 0.119646304167186 582 708373 SGTC_1062 mesoridazine 14.2 µM 1.17290161129578 0.109658056807295 no 401 0.120417631670009 653 4078 A neuroleptic. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.16871432992029 0.110375789170108 no 402 0.12125937324712 636 6312947 SGTC_2653 dihydrofissinolide 100 µM 1.16379542651129 0.11122322229375 no 403 0.122253463012393 627 6857746 SGTC_1573 oleylamine 1.06 µM 1.16362447104602 0.111252758187837 no 404 0.12228811496687 646 5356789 An amine of the fatty acid oleic acid. SGTC_1987 st072290 61.9 µM 1.16296113968258 0.111367414794434 no 405 0.122422634720734 670 54697379 SGTC_2443 5493264 126.67 µM 1.16281960265042 0.111391890368596 no 406 0.122451351047952 648 5340055 SGTC_3320 9137005 35.139 µM 1.16123391647653 0.111666361535497 no 407 0.122773392708718 626 4908713 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.16048453176428 0.111796243000298 no 408 0.122925793965829 693 5106787 A p450 inhibitor. SGTC_2257 7960413 200 µM 1.15847929868078 0.112144316218992 no 409 0.123334247415182 712 2974689 YIL048W NEO1 SGTC_262 fenpropimorph 62.5 µM 1.15813948209818 0.112203379081251 no 410 0.123403560046218 604 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2442 5158906 48.48 µM 1.15406219693815 0.112913778340614 no 411 0.124237335201751 681 1893835 SGTC_1340 1486-1359 257 µM 1.15304237544286 0.113091966174775 no 412 0.12444649591701 672 4309068 SGTC_593 1203-0218 61.7 µM 1.15153242463327 0.113356159969416 no 413 0.124756631859226 692 3666956 SGTC_653 0203-0016 55.2 µM 1.14845956293582 0.113895172742595 no 414 0.125389448527251 663 295302 SGTC_2936 9038235 15.59 µM 1.14774800345082 0.114020247876163 no 415 0.125536304061613 641 4749415 SGTC_1296 1068-0102 11.9 µM 1.1474778451018 0.114067760869628 no 416 0.125592092241709 672 767053 SGTC_821 1114-0266 29.2 µM 1.14680317359931 0.114186477544561 no 417 0.125731488646602 645 3123235 SGTC_2857 9024691 58.44 µM 1.14584974835566 0.114354394342241 no 418 0.125928663382735 609 16478292 SGTC_470 aa-861 153 µM 1.14380270111219 0.114715513115556 no 419 0.126352734700505 697 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1194 1488-0194 225 µM 1.14376805023133 0.114721632839246 no 420 0.126359921616291 696 1391452 SGTC_691 1548-0686 185 µM 1.13701363433372 0.115918975473488 no 421 0.127766292998466 691 46495133 SGTC_1449 4112-4002 201 µM 1.13585182507359 0.116125818328383 no 422 0.128009291574809 639 2059539 SGTC_1028 k015-0029 4.8 µM 1.13519297731174 0.116243232702637 no 423 0.128147235657362 683 4588309 SGTC_1273 0849-0096 14.1 µM 1.13376826775201 0.116497420588357 no 424 0.128445882457237 686 5286025 SGTC_3157 9099274 49.47 µM 1.13279943960311 0.11667049797088 no 425 0.128649243427513 655 17217662 SGTC_1516 st013856 110 µM 1.12678082640434 0.117749784763607 no 426 0.129917579520968 654 5281404 A mutagen and neurotoxin. SGTC_2202 7226349 200 µM 1.12464668472487 0.118134181035234 no 427 0.130369391270134 653 844334 SGTC_1612 st002233 45.4 µM 1.12361140634407 0.118320972125231 no 428 0.130588957531169 682 1035021 SGTC_1579 chlormadinone acetate 49.4 µM 1.12113391313005 0.11876882366703 no 429 0.131115432541513 700 45114258 A steroidal progestin. SGTC_2949 9072542 2.23 µM 1.11811447244205 0.119316259297733 no 430 0.131759053054679 692 16457352 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.11807296280075 0.119323797535267 no 431 0.131767916365766 780 65057 A dermal irritant. YDR527W RBA50 SGTC_567 1080-0542 68.4 µM 1.11581734736396 0.119733927452286 no 432 0.132250163358192 633 5950415 SGTC_735 3076-0345 636 µM 1.11525880685568 0.119835638107206 no 433 0.132369766129844 748 2888990 SGTC_1038 k292-0204 154 µM 1.11309605071405 0.120230052230824 no 434 0.13283358982896 653 4454212 SGTC_1512 0259-0544 12.2 µM 1.11104889340326 0.120604226768039 no 435 0.133273652146967 752 18476 SGTC_747 3448-8087 38.7 µM 1.1106474992668 0.120677688669437 no 436 0.133360054372957 716 5168703 SGTC_2339 9000433 200 µM 1.10901724408354 0.120976376651013 no 437 0.133711371524638 613 2988954 SGTC_1964 st076914 61 µM 1.10577494481051 0.121571961172747 no 438 0.134411971110892 706 24208661 SGTC_2775 cyproheptadine 69.59 µM 1.10472916025151 0.121764502291117 no 439 0.134638482014645 708 2913 A selective serotonin reuptake inhibitor. SGTC_3356 9151811 4.48 µM 1.09907488241777 0.122809231399773 no 440 0.135867702377644 696 1859254 YPR165W RHO1 SGTC_1617 st002906 78 µM 1.09434500133004 0.123687977558717 no 441 0.136901847761641 729 5150859 SGTC_42 0133-0086 60.653 µM 1.09271789029612 0.123991287477529 no 442 0.13725884117312 632 162923 Model of phenazepam hydroxylation. SGTC_1424 4048-1941 275 µM 1.09269570220393 0.123995427155985 no 443 0.137263713702357 786 X1424 SGTC_390 dec-rvkr-cmk 16.7 µM 1.09208747205425 0.124108943585329 no 444 0.137397327713036 732 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_74 000s-0487 160.283 µM 1.09043229218615 0.124418224526661 no 445 0.137761381778083 685 677548 SGTC_582 0987-0078 156 µM 1.08301243215679 0.125811294308545 no 446 0.139401452442103 842 1625765 SGTC_2253 7938677 135.83 µM 1.08220864092403 0.125962855700942 no 447 0.139579914900006 711 2301972 SGTC_3255 9139072 49.47 µM 1.07822926668757 0.12671507437805 no 448 0.140465727080041 721 17646060 SGTC_2358 9037157 4 µM 1.07767623615309 0.126819860453125 no 449 0.140589133559487 729 2388925 SGTC_734 2023-0417 80 µM 1.07751582263924 0.126850266266263 no 450 0.140624942937275 714 3935732 SGTC_2931 9014674 55.67 µM 1.0771322110293 0.126922999066644 no 451 0.140710602302133 689 2996810 SGTC_2144 5628481 200 µM 1.07506714821812 0.127315033920443 no 452 0.141172333157227 691 2818399 SGTC_309 k408-0051 1.48 µM 1.07431567832335 0.12745790298255 no 453 0.141340610219596 783 3640463 SGTC_258 haloperidol 50.781 µM 1.06865446567767 0.128537793653489 no 454 0.142612698229117 711 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_519 k048-0011 62.8 µM 1.06854499909596 0.128558737074395 no 455 0.142637371686986 726 6836379 SGTC_403 arphamenine a 50 µM 1.06510690971225 0.129217726487379 no 456 0.143413776391509 725 5487158 An arginine aminopeptidase inhibitor. SGTC_2130 NSC 7 2.4545 µM 1.06389187650996 0.12945117473609 no 457 0.143688841733973 784 21448 SGTC_726 3448-4391 34.2 µM 1.06117901850375 0.129973459068644 no 458 0.144304276337566 799 1356692 SGTC_289 k017-0060 526 µM 1.06005345887368 0.130190581414854 no 459 0.1445601397381 708 5512909 SGTC_3090 9117696 49.47 µM 1.05792309311536 0.130602219309003 no 460 0.145045252987162 738 7923821 SGTC_2555 cholic acid 100 µM 1.05671593481244 0.130835870347534 no 461 0.145320625166803 737 6708657 Influences liver metabolism. SGTC_1422 4031-0024 15.5 µM 1.05604962191666 0.130964961940246 no 462 0.145472772379301 747 782427 SGTC_903 1134-0042 114 µM 1.05545122502049 0.131080970461536 no 463 0.14560950279655 731 701009 SGTC_3271 9137798 49.47 µM 1.05515624076774 0.13113818385025 no 464 0.145676936871774 667 6498326 SGTC_2191 5911152 200 µM 1.05470618819364 0.131225506597677 no 465 0.145779860366374 749 2875902 SGTC_648 0375-0473 33.3 µM 1.05429342032586 0.13130563037132 no 466 0.145874300102721 777 1713139 SGTC_2673 kobusone 100 µM 1.05282287568143 0.131591357329069 no 467 0.14621108930047 768 6710676 An epoxy ketone and protein crosslinker. SGTC_3269 9137823 49.47 µM 1.04937098196442 0.132263745590495 no 468 0.147003704141328 674 17682936 SGTC_654 1124-0271 80.9 µM 1.04603699061103 0.132915412642381 no 469 0.147771977158002 765 5403748 SGTC_1801 st050089 28.441 µM 1.0452777742596 0.133064118728305 no 470 0.147947303416607 849 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1891 st059073 26.2 µM 1.03826792673172 0.13444253273168 no 471 0.149572668172168 834 688754 SGTC_1703 st026983 48.3 µM 1.03493162152249 0.135102014084237 no 472 0.150350422892035 814 1104023 SGTC_516 3992-2719 87.3 µM 1.03428778593591 0.135229534803977 no 473 0.150500822565688 710 5350887 YDR037W KRS1 SGTC_1242 0402-0103 60.1 µM 1.03396410580469 0.1352936753806 no 474 0.150576471927941 711 432868 SGTC_2768 sulfasalazine 50.2 µM 1.03287748073596 0.135509153917056 no 475 0.150830619249954 766 5384001 An antioxidant and salicylic acid derivative. SGTC_1683 st010134 710 nM 1.03272459762846 0.135539489607553 no 476 0.150866399501188 749 3818134 SGTC_1992 st073643 23.3 µM 1.03225342713322 0.135633010447807 no 477 0.150976706204872 749 3161292 SGTC_1775 st081588 35.1725 µM 1.03149507597192 0.135783625500476 no 478 0.151154358063494 803 1426443 YGL099W LSG1 SGTC_1389 3405-0187 19 µM 1.0291934755055 0.136241444312734 no 479 0.151694383818031 702 799890 SGTC_3095 9117207 49.47 µM 1.02842340117477 0.136394857852841 no 480 0.151875352703037 718 17015229 SGTC_170 4197-0004 226 µM 1.0268700216545 0.136704680286314 no 481 0.152240836067168 714 218692 SGTC_1080 nisoldipine 24.4 µM 1.02405076576303 0.137268210786607 no 482 0.15290564869293 795 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1631 benzylvanillin 81.9 µM 1.02319910884226 0.137438756893104 no 483 0.153106857102151 776 75506 SGTC_2885 9057732 51.95 µM 1.02148838255603 0.137781770484191 no 484 0.153511555216801 746 6471414 SGTC_203 k066-0004 30.888 µM 1.01923582146366 0.138234316327968 no 485 0.154045512145065 912 6795412 SGTC_1610 st001799 48.1 µM 1.01503821942121 0.139080327469929 no 486 0.155043804657446 711 621897 SGTC_377 3970-0964 33.1 µM 1.01412937847986 0.139263964163318 no 487 0.155260510619719 877 16481235 SGTC_704 1310-0270 142 µM 1.00736610926342 0.140635704252384 no 488 0.156879435690032 796 5718033 SGTC_2360 9040895 200 µM 1.0064451121544 0.140823209770551 no 489 0.157100751107008 738 4914414 SGTC_3125 9127534 49.47 µM 1.00643632991506 0.140824998559974 no 490 0.157102862465194 677 1639235 SGTC_887 0885-0007 9.62 µM 1.004117724165 0.141297797580498 no 491 0.157660936611826 816 5719458 SGTC_3248 9135562 49.47 µM 1.0018354639314 0.141764234906964 no 492 0.158211532984875 846 17650701 SGTC_960 1222-0186 7.7 µM 1.0008459451656 0.141966791700486 no 493 0.158450646546758 805 3126296 SGTC_163 TUB2.036 7.546 µM 0.99867257535976 0.142412373079268 no 494 0.158976665016343 925 15992207 YJR013W GPI14 SGTC_1228 0124-0032 52.5 µM 0.998520570866292 0.14244357219506 no 495 0.159013497272659 847 X1228 SGTC_945 3381-0768 11.3 µM 0.996994218655783 0.142757114222569 no 496 0.159383658088469 849 1126236 YIL048W NEO1 SGTC_673 1082-0474 110 µM 0.996523446767478 0.142853913870343 no 497 0.159497940313202 881 3098046 SGTC_1864 st057645 30.4 µM 0.996519993217311 0.142854624149775 no 498 0.159498778877879 790 688666 SGTC_1671 st016596 74.5 µM 0.996111631618475 0.142938627261492 no 499 0.159597954468454 851 2829167 SGTC_1274 0865-0114 173 µM 0.995884293569125 0.142985406902955 no 500 0.159653183768474 796 870624 SGTC_1824 st053723 68.6 µM 0.995030729841819 0.143161138134249 no 501 0.159860659389351 811 675225 SGTC_1846 st056244 14.8 µM 0.994071108751661 0.143358878537265 no 502 0.160094124864849 826 5393182 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.993756662831482 0.143423713651091 no 503 0.160170674638636 970 688664 SGTC_1889 st059080 5.18 µM 0.993131127975239 0.143552750564008 no 504 0.16032302808609 861 176925 Isolated from Daphnopsis sellowiana. SGTC_2557 derrustone 83.84 µM 0.991628694458245 0.143862996406967 no 505 0.160689343203113 823 629853 An antioxidant. SGTC_19 0279-0214 38.434 µM 0.989870208144644 0.14422669014029 no 506 0.16111878142581 890 3566274 YBR002C RER2 SGTC_2816 7982706 58.44 µM 0.98985145394513 0.144230572259695 no 507 0.161123365402691 764 2981853 SGTC_1980 st071811 45.7 µM 0.984470721038675 0.145347293955148 no 508 0.162442060285772 816 4974850 SGTC_2628 lathosterol 100 µM 0.983025825453046 0.145648156802905 no 509 0.162797364182462 818 6710616 SGTC_2508 celastrol 40.54 µM 0.981855592539782 0.14589213479183 no 510 0.16308549790035 768 122724 Celastrol is a natural product and antioxidant. SGTC_2614 arthonioic acid 13.39 µM 0.974055066941852 0.147525455249914 no 511 0.165014599030074 777 6710684 SGTC_1283 0922-0125 16.4 µM 0.972219519855046 0.147911566641202 no 512 0.165470675831474 885 3360884 SGTC_120 rhodamine 6G 52.259 µM 0.971826004802002 0.147994431387207 no 513 0.165568558222123 976 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_297 0986-0032 24 µM 0.971379169469075 0.148088561760466 no 514 0.165679748818879 798 2847425 SGTC_490 phenamil 164 µM 0.96691772263222 0.149030607501452 no 515 0.166792583111285 735 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2125 5246583 200 µM 0.966915450072779 0.149031088375939 no 516 0.166793151189781 919 835267 SGTC_1275 0867-0008 21.1 µM 0.965855657827013 0.149255453791947 no 517 0.167058206657862 843 3422836 SGTC_491 tetrandrine 80.3 µM 0.964705307704493 0.149499246093761 no 518 0.167346218007324 813 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1977 st070720 65.3 µM 0.96222810089049 0.150025139445738 no 519 0.167967518172582 796 682188 SGTC_2661 dactinomycin 12.96 µM 0.96158776025432 0.150161279581822 no 520 0.168128361104532 872 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2001 4023502 57.655 µM 0.959068795190915 0.150697625093853 no 521 0.168762044626286 823 108941 YCR052W RSC6 SGTC_580 1123-0028 41 µM 0.958946890370064 0.150723613750945 no 522 0.168792750502035 946 1677248 YPR107C YTH1 SGTC_1609 st001574 46.4 µM 0.95701760970433 0.151135310766012 no 523 0.169279183397436 847 3960012 SGTC_1255 0566-0045 221 µM 0.956722985737491 0.151198247557861 no 524 0.169353546578243 845 2788469 SGTC_126 0417-1624 672.48 µM 0.956665911349676 0.151210441653112 no 525 0.169367954595408 1026 41912 YDL195W SEC31 SGTC_1908 st060353 56.5 µM 0.953861616435123 0.151810392529775 no 526 0.17007684747452 906 4227716 SGTC_860 0443-0016 25.1 µM 0.950140450240755 0.152608937575353 no 527 0.171020446033374 899 5337942 SGTC_88 0180-0332 8.668 µM 0.948891102600469 0.152877665549117 no 528 0.171338000122048 879 3101745 SGTC_1288 0973-0013 65.5 µM 0.948809972800953 0.152895126976651 no 529 0.171358634388846 878 4315430 SGTC_2882 9058044 58.44 µM 0.948391504376962 0.152985214219215 no 530 0.171465091396759 829 18076804 SGTC_383 2324-0395 7.37 µM 0.945300236707187 0.153651787542322 no 531 0.172252808807077 872 3146421 SGTC_1662 st014054 52 µM 0.944548273600575 0.153814224486708 no 532 0.172444772797138 835 2838777 SGTC_141 0443-0274 32.331 µM 0.942325328054794 0.154295083335625 no 533 0.17301305229047 967 1627241 SGTC_2030 5175110 200 µM 0.942038151189822 0.154357276735961 no 534 0.173086553843186 856 2831986 SGTC_32 0928-0142 34.1 µM 0.938549918950059 0.155114040520111 no 535 0.173980937954115 858 2244242 SGTC_583 1488-1091 88.9 µM 0.933431311766223 0.156228937488388 no 536 0.17529865994745 1030 4303273 SGTC_2812 7970281 58.44 µM 0.932638931353109 0.156401998613621 no 537 0.175503212677411 874 2233435 SGTC_2288 7946289 167.31 µM 0.930842769535131 0.156794759527846 no 538 0.175967451111483 945 1246052 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.929765529556865 0.157030627221938 no 539 0.176246248699721 830 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1380 2291-0730 164 µM 0.925824990076141 0.157895417630375 no 540 0.177268468965337 809 2999191 SGTC_1770 st043884 66.3 µM 0.924200432532367 0.158252851570269 no 541 0.177690985241627 904 670149 SGTC_2975 9084847 53.72 µM 0.923763946786439 0.158348977260966 no 542 0.177804615024102 877 27211724 SGTC_2984 9022109 38.96 µM 0.920731403713867 0.159017880735956 no 543 0.178595338142583 876 6459207 SGTC_1294 1000-1494 117 µM 0.915797904494886 0.160110037952415 no 544 0.179886451401094 858 712797 YDL207W GLE1 SGTC_861 0443-0273 110 µM 0.913970309728079 0.160515865113738 no 545 0.180366223417693 912 6149169 SGTC_2786 7743617 45.45 µM 0.91242141776589 0.16086033046231 no 546 0.180773459551515 792 583674 SGTC_1802 st050112 57.9 µM 0.906184449212176 0.162252279503422 no 547 0.182419116276284 933 4662563 SGTC_581 0958-0271 211 µM 0.904487170642457 0.162632426661932 no 548 0.182868567073494 972 4591145 SGTC_1297 1068-0111 14.1 µM 0.904102581831624 0.1627186452136 no 549 0.182970504748157 868 767057 SGTC_1299 1079-1439 3.74 µM 0.903222246499944 0.16291611396086 no 550 0.183203976589286 880 323161 SGTC_2893 9048488 25.97 µM 0.903091417475816 0.162945473620388 no 551 0.183238689325119 882 6467338 SGTC_1402 3909-7673 35.9 µM 0.902979504380279 0.162970591040046 no 552 0.183268386371198 891 5328014 SGTC_1971 st069429 63.5 µM 0.902795296529721 0.163011939545874 no 553 0.183317273951382 936 1246522 YGL099W LSG1 SGTC_3075 9116269 49.47 µM 0.902046976932183 0.163179982402619 no 554 0.183515956767566 903 17015205 YNL244C SUI1 SGTC_1360 1598-0022 39.8 µM 0.901197334639564 0.163370914729967 no 555 0.183741703932539 976 761525 SGTC_1488 4013-0813 75.9 µM 0.899903554752977 0.16366193265597 no 556 0.184085789118176 882 2910057 SGTC_2641 levomentholum 100 µM 0.897916434811087 0.164109562868777 no 557 0.184615051047539 885 16666 SGTC_2063 5246145 200 µM 0.896350287442045 0.164462921416419 no 558 0.185032854574379 942 711240 SGTC_756 0508-1999 28.3 µM 0.89492260188897 0.164785469194708 no 559 0.18541423182609 868 6753853 SGTC_3164 9100705 49.47 µM 0.892478682106697 0.165338558632661 no 560 0.186068207068689 905 17174235 SGTC_1305 1181-0477 144 µM 0.892110673344605 0.165421947529221 no 561 0.186166807271412 934 6252086 SGTC_1898 st060199 18.6 µM 0.891590923929644 0.165539766420759 no 562 0.186306118340812 907 688866 SGTC_2907 7721985 69.9 µM 0.891357883284259 0.165592610632258 no 563 0.186368602373197 916 3267881 SGTC_1588 farnesol 29.9 µM 0.890323716795368 0.165827249460744 no 564 0.186646044913173 906 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2734 clemastine 41.6 µM 0.889141102351667 0.166095832460835 no 565 0.18696362577574 831 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2506 ethyl hematommate 54.16 µM 0.884955045292267 0.167048782524032 no 566 0.188090438921578 842 3940691 An allergen. SGTC_1807 st050092 58.9 µM 0.884412284597236 0.167172598933508 no 567 0.188236846942017 888 5008496 SGTC_214 4373-3496 70 µM 0.883519059226132 0.167376493298958 no 568 0.188477944758642 1076 3779166 SGTC_986 1493-0483 84 µM 0.882155882233399 0.167687971137171 no 569 0.188846257982669 910 40079 SGTC_728 3030-5151 22.5 µM 0.881843953560326 0.167759297433362 no 570 0.188930599487284 897 3125388 SGTC_1699 st031318 29.054 µM 0.880252619435083 0.168123479388478 no 571 0.189361236879005 974 5340658 SGTC_1832 st054113 55 µM 0.880165225410663 0.168143494518057 no 572 0.189384904419335 928 1251267 SGTC_2142 5622915 118.518 µM 0.87936649253391 0.168326492726124 no 573 0.189601296953321 897 5322196 SGTC_1554 st069299 38.7 µM 0.876542123021492 0.168974612748922 no 574 0.190367693671536 933 24207999 SGTC_1499 4480-0877 67.3 µM 0.875372755481062 0.169243421063698 no 575 0.190685559399259 891 2861909 SGTC_136 0097-0015 404.482 µM 0.874674093407319 0.169404156917356 no 576 0.190875630011839 1039 4861337 SGTC_2687 chenodiol 100 µM 0.873153222376798 0.169754390747813 no 577 0.19128978381059 890 5702181 A cholesterol synthesis inhibitor. SGTC_115 0527-0192 112.043 µM 0.870854189823992 0.170284704414165 no 578 0.19191688622428 1000 4233931 SGTC_2440 5628896 157.78 µM 0.870690938139415 0.170322401699196 no 579 0.191961463852535 937 5522048 SGTC_902 1120-0002 2.07 µM 0.869026173596443 0.170707126209414 no 580 0.192416407455558 943 3280475 SGTC_423 5-fluorouracil 457 µM 0.867677478857425 0.171019215006119 no 581 0.192785459082561 888 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_528 3492-0019 172 µM 0.867655001422464 0.171024419388611 no 582 0.192791613382595 1056 2869262 SGTC_277 nystatin 15.5 µM 0.866027866394077 0.171401432229209 no 583 0.193237440166473 1008 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.863589012038434 0.171967517277161 no 584 0.193906851197551 1026 66535 A nucleotide analog. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.862510090131248 0.172218327363696 no 585 0.194203441513234 1055 6708784 An antioxidant flavonoid SGTC_3140 9094243 49.47 µM 0.858262068113343 0.17320810527111 no 586 0.195373884895207 1051 19291112 SGTC_96 0929-0093 37.281 µM 0.856847745190464 0.173538440999642 no 587 0.195764517477748 917 6991579 SGTC_361 000s-0510 1.45 µM 0.855939126089477 0.173750873612683 no 588 0.196015725802722 939 660 SGTC_2853 9015042 58.44 µM 0.853415816267556 0.174341683528165 no 589 0.196714376811583 949 6457456 SGTC_2919 7978188 46.38 µM 0.851569946848968 0.174774684350328 no 590 0.197226412868648 985 2980291 SGTC_66 0109-0187 42.4 µM 0.850797391858981 0.174956111418571 no 591 0.197440955363758 879 759417 SGTC_855 0428-0020 25 µM 0.848363528802467 0.175528461556215 no 592 0.198117773718674 895 6812414 SGTC_3142 9086498 49.47 µM 0.844817694164643 0.176364425415486 no 593 0.199106316913273 927 25236367 SGTC_685 1278-0033 54.9 µM 0.841786443831469 0.177081064887272 no 594 0.199953750634388 993 3590572 SGTC_2140 5586273 200 µM 0.841692275693272 0.177103357270219 no 595 0.19998011150615 975 854421 SGTC_1070 indatraline 8.81 µM 0.841356772129883 0.17718279529399 no 596 0.200074047372894 961 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1550 gossypolone 36.6 µM 0.841326609064847 0.177189938181318 no 597 0.200082493869144 1026 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_854 0422-0053 192 µM 0.83715154427319 0.178180385893735 no 598 0.201253695217264 1018 3596728 SGTC_801 0866-0028 10.1 µM 0.832484436775611 0.179291682690011 no 599 0.202567779622486 1029 6849771 SGTC_3195 9113082 49.47 µM 0.829530884349182 0.179997207500417 no 600 0.203402034050645 989 17018038 SGTC_753 1322-0200 289 µM 0.829376390246005 0.180034159932414 no 601 0.203445728484696 1015 5403907 SGTC_1769 st044406 64.4 µM 0.829257294238467 0.180062648976811 no 602 0.203479415356747 988 670903 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.826799260322099 0.180651269020552 no 603 0.204175424684408 963 5282362 SGTC_1222 0366-0074 1.18 µM 0.824646870650364 0.181167686770665 no 604 0.204786051559797 1057 286520 SGTC_2844 9010103 25.97 µM 0.823945545246841 0.181336153651718 no 605 0.204985249961067 951 2480525 SGTC_2802 7925815 54.55 µM 0.823511832347376 0.18144038583032 no 606 0.205108495643475 979 1262923 SGTC_1144 3486-0183 12.5 µM 0.821714897178852 0.181872634289759 no 607 0.205619589301834 1020 6744069 SGTC_1859 st055998 20 µM 0.820828690293395 0.182086046181695 no 608 0.205871926985472 1038 676301 SGTC_93 0109-0045 59.227 µM 0.819903355247668 0.182309047722958 no 609 0.206135601945613 1140 88733 SGTC_219 mitoxanthrone 164.414 µM 0.819115725444157 0.18249899732016 no 610 0.20636019535586 966 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1416 3966-0321 25.3 µM 0.818626960091159 0.182616933082476 no 611 0.206499640159356 1045 582530 YLR208W SEC13 SGTC_1106 tegaserod maleate 11.7 µM 0.816832868204574 0.183050243121244 no 612 0.207011973042545 1021 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1439 4092-1168 46 µM 0.816337049737041 0.183170106505996 no 613 0.207153694821515 1029 2886240 SGTC_122 0236-0016 402.397 µM 0.815029826851469 0.183486360329365 no 614 0.207527618586048 1122 6808838 SGTC_2177 5811945 192 µM 0.81452282988688 0.183609108637635 no 615 0.207672749508301 1037 5343475 SGTC_2914 7968218 45.32 µM 0.813721600117557 0.183803197533769 no 616 0.207902228555177 953 2977111 SGTC_2099 5377090 177.372 µM 0.813007041828603 0.183976399006297 no 617 0.208107010406854 982 2243829 SGTC_2954 9074818 52.69 µM 0.809607634333518 0.184801770943181 no 618 0.209082859476875 990 16648742 SGTC_660 4031-1742 102 µM 0.809590862591712 0.184805848798751 no 619 0.209087680718195 989 6738706 SGTC_1994 st072947 40.9 µM 0.808492923200353 0.185072921763888 no 620 0.209403439154327 1004 5286565 YDL195W SEC31 SGTC_2405 ticlatone 3.52 µM 0.807917461057887 0.185212998233759 no 621 0.209569049396636 1032 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1068 loratadine 26.9 µM 0.803342388632145 0.186328983537587 no 622 0.210888431999624 998 3957 A H1 histamine antagonist. SGTC_1935 st074532 41.6 µM 0.80250445787434 0.18653382823804 no 623 0.2111306053791 1120 2829742 SGTC_786 4544-0069 423 µM 0.799449939980199 0.187281730923192 no 624 0.212014781382079 1045 748821 YLR208W SEC13 SGTC_1290 0986-0249 10.2 µM 0.797225163398428 0.187827635655513 no 625 0.212660137151775 1046 53329 SGTC_3212 9128307 49.47 µM 0.794293911699588 0.188548390353145 no 626 0.213512173788235 920 27243542 SGTC_1866 st057638 64 µM 0.793888100416132 0.188648308017516 no 627 0.213630288871817 1026 688802 SGTC_442 cape 100 µM 0.793079365603246 0.18884752965486 no 628 0.213865792025915 1012 5281787 SGTC_859 0439-0102 54.6 µM 0.792553025066655 0.188977256634383 no 629 0.214019143286976 1096 610143 SGTC_3096 9117468 49.47 µM 0.790203780948431 0.18955694312801 no 630 0.214704384146403 971 41316311 SGTC_2120 5538279 151.968 µM 0.789564554548294 0.189714864248531 no 631 0.214891057750019 1034 2058197 SGTC_872 0588-0139 234 µM 0.788563250460777 0.189962399393191 no 632 0.215183658498562 1095 2047100 SGTC_2521 angolensin 13.4 µM 0.785232385207193 0.190787259526835 no 633 0.216158665437705 1045 821428 A flavenoid. SGTC_2324 6149169 200 µM 0.785197581955586 0.190795889838645 no 634 0.216168866491222 1027 2888231 SGTC_665 3914-0008 307 µM 0.782356418140721 0.191501233224746 no 635 0.217002569459141 1061 1069549 SGTC_224 benfluorex 43.875 µM 0.782146407437883 0.191553433521403 no 636 0.217064268064372 1062 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_864 0469-0573 172 µM 0.781961876571095 0.191599307739314 no 637 0.217118489367338 1010 689425 SGTC_1291 0993-0025 5.79 µM 0.781904030977629 0.191613689490356 no 638 0.217135487936501 1073 4353356 SGTC_43 0570-0105 72.5 µM 0.779929846633504 0.192104913620403 no 639 0.217716084639227 1100 1114046 YDL195W SEC31 SGTC_431 k089-0097 107 µM 0.777744745456496 0.192649516377391 no 640 0.218359753906078 1068 5499420 SGTC_2708 st078559 56 µM 0.774793950528442 0.193386452140426 no 641 0.219230712252038 988 17250902 SGTC_2148 5546263 113.568 µM 0.772672777252391 0.193917258093168 no 642 0.219858030747582 1063 792097 SGTC_2313 7726885 200 µM 0.772453187463177 0.193972259281645 no 643 0.219923031308312 1048 726423 SGTC_61 0978-8327 98.565 µM 0.770305575285233 0.19451067789904 no 644 0.220559324978907 1136 6150059 YHR072W ERG7 SGTC_1830 st055982 50.3 µM 0.770202505900338 0.194536540835877 no 645 0.220589888837656 1050 455313 An antimicrobial agent. SGTC_2029 5175081 200 µM 0.76825966968987 0.19502444320677 no 646 0.221166464928135 1136 1380876 SGTC_1218 1348-1416 30.7 µM 0.766133228793606 0.195559305877454 no 647 0.22179851657708 1102 6787668 SGTC_3020 9089140 49.47 µM 0.765469936043528 0.195726325672106 no 648 0.221995880998303 1118 17217859 SGTC_1615 st002656 86.5 µM 0.764917575412995 0.195865478364854 no 649 0.222160313780654 1097 1584458 SGTC_95 0471-0001 561.058 µM 0.764434731786181 0.195987167244021 no 650 0.22230410889941 1067 4015405 SGTC_3285 9112818 20.8695 µM 0.764425309726618 0.195989542298902 no 651 0.222306915400491 1148 17017947 YPR165W RHO1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.762142895731614 0.196565393496133 no 652 0.222987361762159 1028 688803 SGTC_3272 9137413 49.47 µM 0.759963143975303 0.197116298980281 no 653 0.223638307840639 1091 17614870 SGTC_3242 9133940 49.47 µM 0.759684190805426 0.197186868341755 no 654 0.223721690417791 1160 17248444 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.754713358714926 0.198446947255393 no 655 0.225210494672302 1119 5355888 SGTC_1749 st037932 54.2 µM 0.753720162554716 0.198699298170531 no 656 0.225508636163234 1042 594497 SGTC_2843 9000894 45.46 µM 0.751730016340313 0.199205535765685 no 657 0.226106717796267 1003 2242070 SGTC_76 0433-0009 400.328 µM 0.750813844493318 0.199438845181039 no 658 0.226382348143889 989 2841569 SGTC_3044 9093193 49.47 µM 0.74758012689601 0.200263647475341 no 659 0.227356727711225 1115 25236277 SGTC_175 3793-3120 23.7 µM 0.743810371019848 0.20122775644107 no 660 0.228495602499104 1119 5322297 SGTC_295 k015-0027 31 µM 0.743203652850562 0.201383183206436 no 661 0.228679196077913 1103 3887424 SGTC_3355 9151058 44.0485 µM 0.742222504989764 0.201634682165509 no 662 0.228976267700369 1151 17015728 SGTC_1937 st074714 47.2 µM 0.741986171116718 0.201695290053239 no 663 0.229047857139365 1118 17250970 SGTC_1741 st038134 10.228 µM 0.741504286891205 0.201818903198589 no 664 0.22919386673736 1178 1272587 SGTC_557 1315-0110 16.2 µM 0.740304624562511 0.202126838060577 no 665 0.229557587754342 1150 6833801 SGTC_89 0302-0250 142.109 µM 0.740220076013969 0.202148550971968 no 666 0.229583233897635 1211 4203518 YLR208W SEC13 SGTC_2101 5377231 179.231 µM 0.736999896628557 0.202976563563795 no 667 0.230561206114225 1125 2844213 SGTC_1011 4112-3381 17.4 µM 0.736451651407702 0.20311773670173 no 668 0.230727940442694 1144 2877139 SGTC_3319 9138450 16.7555 µM 0.735900267880239 0.203259777060635 no 669 0.230895697117177 1090 2029690 SGTC_3122 9126309 49.47 µM 0.735334987336989 0.203405458914567 no 670 0.231067752592937 1198 17591206 SGTC_418 lividomycin a 100 µM 0.733642957208278 0.203841894340884 no 671 0.23158318631925 1163 72394 An antibiotic. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.732821736391576 0.204053917755482 no 672 0.231833581063742 1149 279621 SGTC_2286 7945697 125 µM 0.732538429815118 0.204127092531647 no 673 0.23191999777146 1128 1245733 SGTC_600 1495-0418 41.6 µM 0.732414102380027 0.20415920978845 no 674 0.231957926901413 1143 5377768 SGTC_14 0354-0009 295 µM 0.73122696679523 0.204466031685467 no 675 0.232320265599675 1171 1713507 SGTC_625 k213-0058 121 µM 0.730349788534241 0.204692919572986 no 676 0.232588200986995 1212 3655420 SGTC_2842 9000675 19.48 µM 0.729746514243053 0.204849047294276 no 677 0.232772571663791 1123 2989072 SGTC_2461 5755302 26.15 µM 0.727486982423587 0.20543444438704 no 678 0.233463843467864 1133 2788904 SGTC_2116 5511452 16.8835 µM 0.725143406994067 0.206042663752654 no 679 0.234182028672657 1132 870744 SGTC_818 4072-2707 53.5 µM 0.725022820048353 0.206073988091702 no 680 0.234219015422631 1128 882871 SGTC_2441 5730946 39.09 µM 0.7250168403353 0.206075541488874 no 681 0.234220849620343 1154 1774275 SGTC_1786 berberine 21.6 µM 0.724518982271332 0.206204898354063 no 682 0.234373588871017 1137 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2973 9094665 17.96 µM 0.724439264945135 0.206225615521322 no 683 0.234398050688242 1175 25237061 YIL048W NEO1 SGTC_2889 9059656 51.95 µM 0.723956652628228 0.206351064536893 no 684 0.234546173804605 1201 3949838 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.723077568718901 0.206579687542583 no 685 0.234816114773088 1244 688801 SGTC_476 mead acid 10 µM 0.722696395340272 0.20667886576415 no 686 0.23493321532727 1163 5312531 An omega 9 fatty acid. SGTC_525 k781-2675 26.7 µM 0.721147708831872 0.207082111333095 no 687 0.23540932019057 1207 3651118 YDL195W SEC31 SGTC_1120 ficusin 1.78878 µM 0.719944472297774 0.207395730009682 no 688 0.235779592394082 1173 6199 A DNA cross-linker. SGTC_2676 harmalol 100 µM 0.719664560080898 0.207468728220859 no 689 0.235865775850412 1161 5459187 A monoamine oxidase inhibitor SGTC_305 1682-2595 20.8 µM 0.718775095916222 0.207700792057479 no 690 0.236139752282837 1164 226033 SGTC_1098 clofazimine 15.1 µM 0.717740752433871 0.207970848092353 no 691 0.236458575384988 1171 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2347 9049783 174.81 µM 0.717623062936889 0.208001588693072 no 692 0.236494866668217 1154 6467988 YPL169C MEX67 SGTC_2903 5923464 63.88 µM 0.716368824589982 0.208329363447914 no 693 0.236881819814125 1196 2876576 SGTC_2212 7123476 200 µM 0.715066535198095 0.208670017775421 no 694 0.23728396556969 1120 1085715 SGTC_2776 terbinafine 19.92 µM 0.712367646122898 0.209377040627023 no 695 0.238118572430697 1188 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3317 9138495 8.753 µM 0.711772925142629 0.209533027885929 no 696 0.238302700541283 1178 17020139 SGTC_475 α-linolenic acid 10 µM 0.711656070487532 0.209563685313066 no 697 0.238338888397602 1252 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1766 st045414 44.774 µM 0.711026011401045 0.209729030053806 no 698 0.238534058602487 1225 253960 SGTC_2428 5615643 7.78 µM 0.709375510214655 0.210162530206184 no 699 0.239045740490931 1169 2253075 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.708011181436749 0.210521264881033 no 700 0.23946915691458 1197 364106 SGTC_927 2425-1185 123 µM 0.705454637407175 0.211194445750375 no 701 0.240263676204361 1184 730375 SGTC_1043 0916-0009 19.3 µM 0.705253295543947 0.21124751596293 no 702 0.240326309914408 1229 3101130 SGTC_2923 7992654 58.14 µM 0.702528540028978 0.211966482111484 no 703 0.24117480482153 1190 2985126 SGTC_2760 etidronate 98.04 µM 0.700873152900115 0.212403977951498 no 704 0.241691090134638 1201 3305 A chelator and antioxidant. SGTC_1773 st048542 73.5835 µM 0.699168378182991 0.212855077224557 no 705 0.242223404974855 1150 3237138 SGTC_3275 9138069 49.47 µM 0.697662298097284 0.213254064865352 no 706 0.242694205744817 1185 17617007 SGTC_1955 wogonin 32.4 µM 0.697522810571967 0.213291039666598 no 707 0.242737834608982 1220 5281703 A flavanone. SGTC_114 0364-0001 490.298 µM 0.696625601394092 0.213528957656026 no 708 0.243018564862751 1192 4003655 SGTC_2771 fluoxetine 41.05 µM 0.696416488399054 0.21358443153648 no 709 0.243084020029741 1193 3386 A selective serotonin reuptake inhibitor. SGTC_2652 actinonin 100 µM 0.695397990478027 0.213854740565435 no 710 0.243402959774171 1179 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1027 k015-0025 8.67 µM 0.695317734964909 0.213876048816845 no 711 0.243428101168067 1190 3598955 SGTC_210 3551-0445 56.827 µM 0.692770281304649 0.214553052999013 no 712 0.244226862632603 1231 2865180 YOR207C RET1 SGTC_1459 k035-0031 35.7 µM 0.691737139951048 0.21482797243982 no 713 0.24455120937671 1098 3877128 YMR208W ERG12 SGTC_3240 9133527 49.47 µM 0.689988375351452 0.215293785666185 no 714 0.245100748846474 1190 17617455 SGTC_379 3970-0972 5.9 µM 0.688912379815514 0.215580686422714 no 715 0.245439204177412 1210 2898042 YBL034C STU1 SGTC_2918 7977171 22.06 µM 0.687403795219306 0.21598330474134 no 716 0.245914153342235 1172 2236483 SGTC_1727 st034309 9.9045 µM 0.685447335010674 0.216506102523498 no 717 0.246530841486687 1246 870305 SGTC_1515 3460-0031 42.1 µM 0.685345466356953 0.216533343513866 no 718 0.246562973782627 1182 2876596 SGTC_723 4182-0001 115 µM 0.684447412113218 0.216773580574891 no 719 0.246846342901358 1173 744821 YLR208W SEC13 SGTC_3302 9125395 16.351 µM 0.68347098962909 0.217034956598611 no 720 0.247154637778184 1190 17599668 SGTC_230 MPP+ 141.667 µM 0.683041248160845 0.217150050679019 no 721 0.247290389248786 1188 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2300 7976697 71.57 µM 0.681676108538597 0.217515898492519 no 722 0.247721888912892 1144 2236109 SGTC_140 0062-0056 502.533 µM 0.681311309462462 0.217613722283152 no 723 0.247837264335047 1207 3758964 SGTC_1822 st052468 42 µM 0.681150012512767 0.217656983443669 no 724 0.247888287050452 1209 2873678 SGTC_862 0452-0056 10.2 µM 0.681017073825117 0.217692642416625 no 725 0.247930343472416 1170 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_45 0kpi-0036 14.9 µM 0.674490759476595 0.219447376570501 no 726 0.249999679274407 1222 2795021 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.673701832694432 0.219660044946598 no 727 0.250250448240819 1264 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2359 9039622 200 µM 0.672483757109953 0.219988629850262 no 728 0.250637888621355 1207 6463596 SGTC_3045 9092950 49.47 µM 0.672109467260612 0.220089653921922 no 729 0.250757004952914 1256 44120432 SGTC_2862 9027634 71.43 µM 0.672104723823658 0.220090934387375 no 730 0.250758514726145 1175 5012562 SGTC_1734 st037168 69.4 µM 0.671832241795768 0.220164496627354 no 731 0.250845250230092 1225 708907 SGTC_195 4234-0266 16.654 µM 0.668120244879871 0.221168031614341 no 732 0.252028419962711 1235 2303354 SGTC_2060 5238662 140 µM 0.667479560737852 0.221341504427384 no 733 0.252232930536464 1214 790130 SGTC_547 1120-0019 610 nM 0.664867697636799 0.222049501920757 no 734 0.253067559051817 1218 3676939 SGTC_2150 5556613 200 µM 0.663849134750905 0.222325953675705 no 735 0.253393437146082 1258 743190 SGTC_177 1327-0068 8.361 µM 0.663569026447715 0.222402013270175 no 736 0.25348309339657 1253 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.661183998910673 0.223050235907267 no 737 0.254247160762576 1268 6708739 YPR165W RHO1 SGTC_2396 5342950 42.78 µM 0.655583704067671 0.224576552368689 no 738 0.256046006721562 1263 1886677 SGTC_906 1165-0455 526 µM 0.653768055085935 0.225072662270825 no 739 0.256630625154562 1243 3252859 SGTC_424 splitomicin 100 mM 0.65349684810006 0.225146820433023 no 740 0.256718010368288 1235 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2406 ethylparaben 405.7 µM 0.65236926203045 0.225455293130267 no 741 0.25708149428645 1170 8434 A possible steroid mimic. SGTC_815 1582-0027 36.9 µM 0.652244525199124 0.225489431962842 no 742 0.257121720364509 1301 3128206 SGTC_198 3454-2873 16.191 µM 0.648677510302599 0.226466914492379 no 743 0.258273421935459 1253 710957 SGTC_370 0180-0345 38.7 µM 0.648640582935146 0.22647704633523 no 744 0.25828535884365 1225 3989527 SGTC_2070 5230947 200 µM 0.648315625012177 0.226566216789058 no 745 0.258390415022604 1330 2835538 SGTC_22 0964-0034 14.468 µM 0.645967917193569 0.227211030790173 no 746 0.259150066565658 1244 138402 SGTC_1719 st032227 49.2 µM 0.645325900535766 0.227387544982399 no 747 0.259358005768179 1282 3125804 SGTC_317 4495-0002 170 µM 0.644874182788139 0.227511785230193 no 748 0.259504361761253 1232 15991618 SGTC_1961 st076550 68.7 µM 0.643603247140869 0.227861547821658 no 749 0.25991637204304 1259 1579337 SGTC_1463 k081-0032 34.1 µM 0.642404107548811 0.228191829294643 no 750 0.260305416701045 1171 977755 SGTC_72 0744-0168 198.391 µM 0.642369007878778 0.22820150092135 no 751 0.260316808833159 1233 677577 SGTC_931 2812-0076 566 µM 0.641856056163989 0.22834286978038 no 752 0.260483324421046 1301 3450959 SGTC_2043 5101342 149 µM 0.640650434450878 0.228675331343429 no 753 0.260874912013605 1266 678451 SGTC_3129 9127257 49.47 µM 0.639167244743487 0.229084707524439 no 754 0.261357069119363 1192 837894 SGTC_3135 9127742 49.47 µM 0.638802684375116 0.229185392979832 no 755 0.261475650885054 1286 3643468 SGTC_546 peri-Naphthalide 147 µM 0.637317391904183 0.229595862253912 no 756 0.26195906230303 1252 223824 A penicillin ester. SGTC_3068 9116768 49.47 µM 0.634925687409574 0.230257688500731 no 757 0.262738441410543 1266 41904888 SGTC_599 1935-0052 86.5 µM 0.634595857280195 0.230349041878678 no 758 0.262846015370166 1269 9557311 SGTC_920 mycophenolic acid 780.421 nM 0.633843639991585 0.230557460039984 no 759 0.263091434955212 1294 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2863 9028737 58.44 µM 0.631194804702865 0.231292215778316 no 760 0.263956579257754 1294 6460917 SGTC_2071 5230951 39.92 µM 0.630605584591968 0.231455835909333 no 761 0.264149223223235 1317 1799272 SGTC_995 3931-2021 34.6 µM 0.62969315150434 0.231709336133267 no 762 0.264447682079088 1298 730143 SGTC_785 1270-0111 65.3 µM 0.628542585790956 0.232029216889041 no 763 0.264824279140115 1294 6741994 SGTC_316 k060-0003 58.6 µM 0.628379048454 0.232074703555346 no 764 0.264877829434359 1324 6152314 SGTC_3316 9136639 10.545 µM 0.628100412324875 0.232152215508031 no 765 0.264969081499086 1355 4903665 SGTC_346 4513-0042 7.16 µM 0.627886675621202 0.232211683280609 no 766 0.265039090122133 1307 2827372 SGTC_783 0848-0141 92.7 µM 0.626468286105796 0.232606535244486 no 767 0.265503916048025 1291 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1279 0874-0590 65.2 µM 0.625626263589474 0.232841114328792 no 768 0.265780054011646 1333 3523074 SGTC_3138 9097216 49.47 µM 0.625338669604889 0.232921265249824 no 769 0.265874402666658 1306 25237486 SGTC_306 1672-3436 11.6 µM 0.624421568174713 0.233176958894501 no 770 0.266175382101901 1325 6797378 SGTC_2368 9071271 200 µM 0.622181672967217 0.233802110279165 no 771 0.266911207783665 1274 27209959 SGTC_823 0417-1665 178 µM 0.62210818582932 0.233822636154308 no 772 0.26693536636632 1324 3429856 SGTC_1366 1683-0113 21.9 µM 0.621768751286503 0.233917457418235 no 773 0.267046968353745 1309 708623 SGTC_881 0833-0569 170 µM 0.621767212287675 0.233917887387086 no 774 0.267047474411665 1280 5418700 SGTC_969 1313-0238 134 µM 0.620952690100353 0.234145511807094 no 775 0.26731537581731 1329 5212874 SGTC_2336 9001819 198.65 µM 0.619853345389736 0.234452926432351 no 776 0.267677172009133 1405 2989602 SGTC_7 0192-1582 4.227 µM 0.615055472054151 0.235797187522083 no 777 0.269259043548356 1357 252616 SGTC_493 zm226600 134 µM 0.612322620301357 0.236564769438008 no 778 0.270162163237875 1350 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1293 1000-1278 195 µM 0.611402057985854 0.236823638975277 no 779 0.270466720273738 1382 678847 SGTC_2370 9071495 200 µM 0.611341264658769 0.236840740029761 no 780 0.270486839056482 1276 21791103 SGTC_1034 k072-0165 12.7 µM 0.611048550515416 0.236923089500698 no 781 0.270583719567101 1334 5835461 SGTC_2749 bexarotene 57.39 µM 0.610508809194861 0.2370749765592 no 782 0.270762404865684 1299 82146 An retinoic acid receptor inhibitor. SGTC_2450 5739737 12.93 µM 0.609861405757988 0.237257231064186 no 783 0.270976810170896 1320 2262825 SGTC_871 0574-0004 149 µM 0.609834803464291 0.237264721684429 no 784 0.270985622057431 1341 9551173 SGTC_3209 9113616 49.47 µM 0.609465401619648 0.237368750534899 no 785 0.271107999480478 1352 16649353 SGTC_2200 6600604 21.907 µM 0.608838609598122 0.237545321431282 no 786 0.271315709538418 1289 2904777 SGTC_790 1575-0012 79.1 µM 0.608433956551964 0.23765935278879 no 787 0.271449847981475 1352 378741 YLR208W SEC13 SGTC_614 0462-0418 107 µM 0.608308143618731 0.23769481303319 no 788 0.271491560444013 1236 5188303 SGTC_2390 9097792 176.6 µM 0.607383933152248 0.237955389749787 no 789 0.271798074270255 1288 4497149 SGTC_123 0083-0120 66.675 µM 0.607020300640633 0.238057957110803 no 790 0.271918719955894 1273 16001701 SGTC_1473 k844-0725 134 µM 0.606883209205127 0.238096631852751 no 791 0.271964210949588 1376 54682906 SGTC_125 0133-0007 11.75 µM 0.606798848834202 0.238120432392627 no 792 0.271992206097376 1402 26541 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.605631977219227 0.238449774869502 no 793 0.272379581587277 1307 77254 SGTC_1188 1403-0014 4.57 µM 0.60525559052432 0.238556060918466 no 794 0.272504592049821 1343 9614867 SGTC_2835 9006588 71.43 µM 0.604445846302771 0.238784808618904 no 795 0.272773631406328 1336 2345538 SGTC_2235 salicylic acid 500 µM 0.602848705673256 0.23923634242407 no 796 0.273304671001283 1345 338 A COX inhibitor and kinase inhibitor. SGTC_613 3914-0030 117 µM 0.602599208203786 0.239306920926023 no 797 0.273387673619637 1179 1145395 SGTC_1280 0880-0253 10.1 µM 0.60160050539061 0.239589550469586 no 798 0.273720046200636 1330 6836607 SGTC_2720 fluspirilene 36.88 µM 0.600823423729765 0.239809587954728 no 799 0.273978800505092 1331 3396 An atypical antipsychotic. SGTC_679 0422-0091 41.4 µM 0.600039268720727 0.240031740029783 no 800 0.274240032600358 1330 627384 YHR062C RPP1 SGTC_463 ikarugamyin 104 µM 0.599605927688858 0.240154554195639 no 801 0.274384447861522 1377 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_579 4491-1009 110 µM 0.599495503955009 0.240185855111763 no 802 0.274421253683085 1430 1271041 SGTC_3351 9150312 21.596 µM 0.598198068405613 0.24055379508263 no 803 0.274853890071693 1337 4904905 SGTC_1045 1348-1485 165 µM 0.596464225001287 0.241045974744795 no 804 0.275432573158031 1342 6810614 SGTC_820 1582-0060 59.9 µM 0.596347414886785 0.241079152872908 no 805 0.275471580940582 1322 3848840 SGTC_1711 st032263 62.8 µM 0.596226412275528 0.241113524433749 no 806 0.275511991638535 1367 3958979 SGTC_1730 st033808 45.1 µM 0.592644412229202 0.242132220099918 no 807 0.276709575056522 1405 1045166 SGTC_349 k015-0014 24 µM 0.592247827402087 0.242245149346004 no 808 0.276842323404848 1325 2196908 SGTC_1939 st074455 53.6 µM 0.591925506494481 0.242336952644995 no 809 0.276950236454833 1448 1644229 SGTC_1704 st028805 70.8 µM 0.591106354538918 0.242570347958003 no 810 0.277224581198792 1338 2876101 SGTC_2468 5987765 72.9 µM 0.59109645335611 0.242573169778062 no 811 0.277227898047863 1417 26772094 SGTC_1759 st043059 70 µM 0.59056201827396 0.24272550922936 no 812 0.277406960051323 1338 669426 SGTC_1201 1889-3372 45.9 µM 0.590124999456671 0.242850118884264 no 813 0.277553424830841 1303 5392199 SGTC_189 3970-0742 2.116 µM 0.589806879796731 0.242940847914346 no 814 0.277660064882491 1376 2891807 SGTC_1115 galangin 695.678 nM 0.588194342277453 0.243401032159664 no 815 0.278200927255241 1392 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1694 st024011 44.9 µM 0.58752435254047 0.243592371530674 no 816 0.278425799972872 1404 2787533 SGTC_3305 9127027 53.8275 µM 0.586995908850349 0.243743344682311 no 817 0.278603227190209 1344 41905295 SGTC_2167 5876490 200 µM 0.58659716551922 0.243857296657768 no 818 0.278737143399952 1535 686534 SGTC_2062 5245942 200 µM 0.585842756437765 0.244072968623123 no 819 0.27899059409294 1412 1376160 SGTC_1764 st044502 93.5 µM 0.585400223491219 0.244199528677598 no 820 0.279139319264086 1333 8407 SGTC_429 1112-0049 25.5 µM 0.584593041188908 0.244430465947799 no 821 0.279410693947887 1319 2836170 SGTC_1247 0448-0043 5.84 µM 0.584390999486462 0.244488289091449 no 822 0.279478640413764 1392 3089013 YGL099W LSG1 SGTC_2151 5563267 85.4165 µM 0.583979348846336 0.244606123876449 no 823 0.279617103024702 1361 5310824 SGTC_404 fumagillin 50 µM 0.582355825870246 0.245071154544377 no 824 0.280163514833751 1375 12015870 A methionine aminopeptidase binder. SGTC_2264 7948757 110.76 µM 0.580406008226738 0.245630274701742 no 825 0.280820427188654 1338 2971411 SGTC_1148 3909-7663 27.7 µM 0.580268500017037 0.245669731727238 no 826 0.280866783127964 1423 4084526 SGTC_1991 st073000 8.92 µM 0.580262446330951 0.245671468868623 no 827 0.28086882399516 1417 4301969 YIL048W NEO1 SGTC_2870 9038528 12.99 µM 0.579584992858274 0.245865909855501 no 828 0.281097257821747 1356 6463316 SGTC_261 5-fluorouridine 15.376 µM 0.578851994113472 0.246076386305364 no 829 0.281344522271285 1408 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1647 st011722 22.4 µM 0.578507611066601 0.24617530731422 no 830 0.281460730174124 1371 2854783 SGTC_1153 4055-0057 267 µM 0.577455969850141 0.246477513969529 no 831 0.281815737081681 1338 882706 SGTC_1362 1611-0397 101 µM 0.576593369708051 0.246725544836914 no 832 0.282107089606733 1372 27816 SGTC_652 0437-0092 114 µM 0.576422270784432 0.246774758266802 no 833 0.282164897349379 1339 3091274 SGTC_104 0074-0074 590.992 µM 0.573906534686875 0.247498969413603 no 834 0.283015525406931 1262 3943124 SGTC_2981 9013952 38.96 µM 0.572309944832068 0.247959172045399 no 835 0.283556006773024 1274 2996344 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.572166081955666 0.248000661637928 no 836 0.2836047318533 1346 689007 SGTC_1982 st072467 71.9 µM 0.572097205295942 0.248020526757066 no 837 0.283628061186926 1363 3163533 SGTC_84 0443-0269 128.823 µM 0.571495322032929 0.248194155538812 no 838 0.283831965225558 1329 6150058 SGTC_300 r073-0011 5.04 µM 0.571456743493343 0.248205286725725 no 839 0.283845037129521 1407 2735780 SGTC_870 0573-2213 57.6 µM 0.571423688684079 0.248214824345192 no 840 0.283856237608876 1360 3916321 SGTC_1564 D-Arginine 115 µM 0.57126346815889 0.248261057071283 no 841 0.283910530639677 1306 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3213 9129884 49.47 µM 0.569695523064228 0.248713740559294 no 842 0.284442113537071 1293 17190742 SGTC_2341 7987486 176.74 µM 0.568669244810381 0.249010276547421 no 843 0.284790311555207 1425 1258686 SGTC_994 3910-0338 138 µM 0.568128479696707 0.249166602524267 no 844 0.284973865360093 1484 3479481 SGTC_951 1171-0579 82.7 µM 0.566814438040747 0.249546686987386 no 845 0.285420130111931 1340 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2592 piperlongumine 83.33 µM 0.566020174142167 0.249776575841142 no 846 0.285690033193828 1329 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_740 k014-0057 261 µM 0.565266364728359 0.249994859654004 no 847 0.28594630147416 1458 4012779 SGTC_1462 k081-0014 26.5 µM 0.564925594790825 0.250093571074203 no 848 0.286062186936528 1234 3270634 SGTC_2856 9022925 19.48 µM 0.562977180018985 0.250658368631806 no 849 0.286725211579692 1411 4944862 SGTC_499 genistein 192 µM 0.56260700479708 0.250765749648825 no 850 0.286851260546827 1424 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.561235319743693 0.251163862488785 no 851 0.287318564049792 1500 16725076 SGTC_1888 azatryptophan 97.5 µM 0.561181780479435 0.251179408304294 no 852 0.287336811023544 1374 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1109 tnp00067 928.257 nM 0.560567118301062 0.251357919843367 no 853 0.287546336260612 1378 676295 SGTC_1661 st013063 9.66 µM 0.55940254546453 0.251696321459275 no 854 0.28794351228027 1426 721395 SGTC_2600 tangeritin 87.95 µM 0.558602323624182 0.25192898933983 no 855 0.288216576929414 1343 68077 A bioactive flavone. SGTC_2317 5986382 200 µM 0.55746725446744 0.252259210088437 no 856 0.288604112979151 1494 877883 SGTC_2220 6782180 200 µM 0.556975503610796 0.252402343857893 no 857 0.288772083052132 1375 833803 SGTC_3193 9111931 49.47 µM 0.55664363927922 0.252498963692406 no 858 0.28888546580173 1433 17087244 SGTC_2082 5219693 150 µM 0.555811106322724 0.252741435221765 no 859 0.289169996118701 1382 2834649 SGTC_2869 9037858 32.47 µM 0.555328623157722 0.252882012399089 no 860 0.289334952082426 1344 27187042 SGTC_2866 9034245 58.44 µM 0.554399524624116 0.253152832135981 no 861 0.289652725679079 1413 6462273 SGTC_2556 citropten 84.59 µM 0.554368926207596 0.253161753757069 no 862 0.289663193844551 1376 2775 A potential DNA crosslinker. SGTC_1155 4088-0394 48.2 µM 0.553551938466454 0.253400025100552 no 863 0.28994276293561 1365 2326248 SGTC_3341 9147222 25.867 µM 0.552919988492657 0.253584411702266 no 864 0.290159099783782 1399 1939759 SGTC_1520 flindersine 88 µM 0.551742374404527 0.253928196879416 no 865 0.290562436715287 1550 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1448 4255-0083 152 µM 0.551548794356999 0.253984732807939 no 866 0.290628763655291 1537 5399660 SGTC_1735 st034310 56.75 µM 0.551394615985728 0.254029766023314 no 867 0.29068159534172 1500 871153 SGTC_2256 7954252 200 µM 0.550311150656165 0.254346348293739 no 868 0.291052988714585 1356 2972920 SGTC_798 1287-0182 476 µM 0.549614802925247 0.254549926168787 no 869 0.291291801749175 1474 1649755 SGTC_1809 st050081 57.6 µM 0.549494411235961 0.254585131438416 no 870 0.291333099450396 1474 5036894 SGTC_2994 9053520 71.4286 µM 0.546597933989533 0.255432895513628 no 871 0.292327494392229 1481 4647384 SGTC_2709 st078560 56 µM 0.544826911546742 0.255951978302378 no 872 0.292936283954067 1518 17250903 SGTC_1314 1222-0010 41.1 µM 0.54460460931083 0.256017173457231 no 873 0.293012741965082 1427 3526027 SGTC_2496 diffractaic acid 79.83 µM 0.542685727262337 0.256580288908192 no 874 0.293673101444973 1535 94870 An apoptosis inducer which activates caspases. SGTC_598 3937-0236 20.2 µM 0.539084037860227 0.257638980427338 no 875 0.294914434529206 1462 1379313 SGTC_1795 st049545 62.3 µM 0.537853441537228 0.25800122483864 no 876 0.295339116793758 1417 5291882 SGTC_1833 st055984 71 µM 0.537716914152337 0.258041429988384 no 877 0.295386250116209 1416 676288 SGTC_201 4262-0159 12.803 µM 0.53413167775777 0.259098387133393 no 878 0.296625217244342 1443 1341029 SGTC_1806 st050005 60.3 µM 0.533532261915354 0.259275318007044 no 879 0.296832592245703 1397 5194765 SGTC_1365 1672-3266 55.4 µM 0.533424039335166 0.259307268953445 no 880 0.296870040198063 1465 6415873 SGTC_482 fipronil 114 µM 0.533328239906073 0.259335553865249 no 881 0.296903191206578 1459 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_853 0419-0306 21 µM 0.533179608667368 0.259379440595762 no 882 0.296954627803554 1372 762713 SGTC_966 1300-0360 30.2 µM 0.532430517966893 0.259600684929668 no 883 0.297213926561866 1438 70588 SGTC_2172 5754775 163.918 µM 0.531955939141727 0.259740902435842 no 884 0.297378256195321 1363 2263357 SGTC_2095 5432005 200 µM 0.530436662049674 0.260190045770042 no 885 0.297904606277196 1438 783734 SGTC_565 1418-0001 44.5 µM 0.530231876250704 0.260250617120834 no 886 0.297975586323304 1484 2862145 SGTC_1050 3232-1156 69.3 µM 0.529182614983349 0.260561080583299 no 887 0.298339387751338 1403 700529 SGTC_1385 3091-4834 14.1 µM 0.528119842930953 0.260875735982603 no 888 0.298708079634145 1484 4072814 SGTC_1695 st026914 34.495 µM 0.524005595484571 0.262095683257504 no 889 0.300137324017305 1406 3289191 SGTC_1492 4158-0558 28.5 µM 0.523360856377627 0.262287124481529 no 890 0.300361579319162 1540 3967268 SGTC_2827 7993847 71.43 µM 0.521695066742508 0.262782075778931 no 891 0.300941330024498 1464 2985692 SGTC_399 oxolinic acid 75 µM 0.520128944617356 0.263247848460165 no 892 0.301486852819862 1419 4628 A DNA gyrase inhibitor. SGTC_764 1951-2361 146 µM 0.519339957153576 0.263482656963629 no 893 0.301761846998849 1399 5438930 SGTC_2798 7813637 45.45 µM 0.518666938046501 0.263683036878124 no 894 0.301996510571772 1507 956368 SGTC_1235 benzylparaben 21.5 µM 0.516314218335184 0.264384129199788 no 895 0.302817483644342 1432 7180 SGTC_717 1532-0246 73.2 µM 0.516040738372039 0.264465685635138 no 896 0.302912978294651 1420 9561992 SGTC_2930 9013230 14.89 µM 0.513462822253527 0.26523509326818 no 897 0.303813805277396 1542 2995857 SGTC_1407 3909-7909 12.3 µM 0.512519706283341 0.265516860362944 no 898 0.30414366605388 1450 4411780 SGTC_3049 9092223 49.47 µM 0.511862022078875 0.265713441157826 no 899 0.304373789663233 1462 8623917 SGTC_1761 st044296 37 µM 0.511645096876868 0.265778295945444 no 900 0.304449708756839 1441 1826700 SGTC_142 0335-0849 62.6745 µM 0.508521388753522 0.266713089291901 no 901 0.305543871558228 1509 3889043 YPR107C YTH1 SGTC_181 1447-1644 8.07 µM 0.508346494895907 0.26676547669238 no 902 0.30560518433131 1477 534600 SGTC_689 0833-0039 98 µM 0.507054455322355 0.267152653016261 no 903 0.306058305170238 1510 5374726 SGTC_921 1561-0023 372 µM 0.504797399979036 0.267829688660755 no 904 0.306850571083071 1441 24050882 SGTC_3056 9094900 49.47 µM 0.504328858992802 0.267970342410398 no 905 0.307015150472775 1397 25236784 SGTC_1474 0330-0125 5.35 µM 0.503302802704055 0.268278489427129 no 906 0.307375698122554 1474 X1474 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.502581491728984 0.268495221453885 no 907 0.307629272302669 1590 551469 SGTC_618 k072-0232 33.2 µM 0.502151442331676 0.268624480099481 no 908 0.307780498317845 1485 5872756 YGL099W LSG1 SGTC_961 1252-1571 372 µM 0.501127325174411 0.268932421746083 no 909 0.308140758539721 1588 6813498 SGTC_1103 duloxetine 36.1 µM 0.501012552750452 0.268966943691424 no 910 0.308181144296593 1589 60835 A selective serotonin reuptake inhibitor. SGTC_2736 butenafine 14.65 µM 0.500447329593524 0.269136987386669 no 911 0.308380067102809 1520 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1507 4075-3230 155 µM 0.499724837656877 0.269354422878069 no 912 0.308634420509411 1433 659771 SGTC_1685 st024049 53.0905 µM 0.498564019658771 0.269703957880998 no 913 0.309043278976809 1476 1941139 SGTC_3146 9095609 49.47 µM 0.495463711016751 0.270638607016889 no 914 0.310136415865426 1552 17173999 SGTC_1398 3558-0053 112 µM 0.495041421354599 0.270766039619438 no 915 0.310285441061199 1456 4532369 SGTC_2012 4023501 200 µM 0.494387059561951 0.270963562821231 no 916 0.310516425596547 1439 3477460 SGTC_817 1391-0715 46 µM 0.493561649667981 0.27121282045556 no 917 0.310807895343961 1466 1353946 SGTC_1765 st044815 90.4 µM 0.493215355735552 0.271317428474569 no 918 0.31093021445399 1418 645695 SGTC_2713 st079149 53.4 µM 0.493062838289483 0.271363507123144 no 919 0.31098409380851 1521 3103253 SGTC_1956 st077085 54 µM 0.491955055571711 0.271698307982127 no 920 0.31137555823304 1467 24208685 SGTC_2384 9036245 200 µM 0.490122753185621 0.27225252853621 no 921 0.312023519128068 1568 6462766 SGTC_2382 9035899 200 µM 0.488843979883869 0.272639654493601 no 922 0.312476079408782 1496 6462679 SGTC_905 2-aminofluorene 215 µM 0.488361808602489 0.272785694202292 no 923 0.312646794233351 1490 1539 An established DNA mutagen. YPR165W RHO1 SGTC_159 3970-0959 50 µM 0.485024338411383 0.273797607608332 no 924 0.313829540561357 1569 6615653 SGTC_91 0417-1751 58.384 µM 0.483156067783806 0.274364872323878 no 925 0.314492463118702 1529 6795624 SGTC_1419 3993-2473 62.6 µM 0.482763325122798 0.274484194894367 no 926 0.314631897069543 1533 704026 SGTC_344 k064-0035 6.43 µM 0.479934065899137 0.275344532718779 no 927 0.31563713860475 1463 5088750 SGTC_2658 polymyxin b sulfate 77.05 µM 0.479770009533775 0.275394460622175 no 928 0.315695470121124 1490 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1636 st007707 68.9 µM 0.47916428615468 0.27557884132019 no 929 0.315910879540574 1603 403051 SGTC_2940 9060638 45.86 µM 0.478891079150246 0.27566202471669 no 930 0.316008058815702 1529 4027022 SGTC_2152 5568786 200 µM 0.478449233994233 0.275796579527248 no 931 0.316165249307915 1502 5399883 SGTC_1614 st002383 48.6 µM 0.478008938943623 0.275930694382399 no 932 0.316321921394827 1509 1947235 SGTC_1464 k208-0027 110 µM 0.475047190244613 0.276833681261014 no 933 0.317376669058228 1598 X1464 SGTC_1118 chelidonine 707.474 nM 0.473368596482855 0.27734609778792 no 934 0.317975115173531 1640 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_643 k048-0106 28.4 µM 0.471085951841145 0.278043653429372 no 935 0.318789678341397 1581 6763920 SGTC_369 0957-0393 4.5 µM 0.470013871226744 0.278371566762163 no 936 0.319172553645224 1478 6997992 SGTC_1058 3448-5425 97.3 µM 0.468752281334298 0.278757685834568 no 937 0.31962335608888 1468 7279705 SGTC_333 3486-0131 40.1 µM 0.467434504006833 0.279161279660262 no 938 0.320094520665075 1634 6744690 SGTC_2937 9044753 11.33 µM 0.46607623171461 0.279577572885011 no 939 0.32058046783674 1476 6465530 YGL099W LSG1 SGTC_2900 5328528 85.29 µM 0.465773240020329 0.279670477090661 no 940 0.320688910754135 1470 795359 SGTC_1857 st056007 79.3 µM 0.46447201248779 0.280069633564322 no 941 0.321154803401209 1535 619834 SGTC_3286 9117135 37.221 µM 0.464410659528856 0.280088460631316 no 942 0.321176777226593 1475 3438150 SGTC_2330 7979373 200 µM 0.462142528677912 0.280784900430971 no 943 0.32198955688889 1433 1863007 SGTC_1849 st056239 19.2 µM 0.461956473574708 0.280842066630712 no 944 0.322056267196545 1435 5393181 SGTC_1023 4482-3888 16 µM 0.461841648883842 0.280877349799477 no 945 0.322097440605446 1639 3303168 SGTC_1867 st057372 64 µM 0.460626968037144 0.281250726388657 no 946 0.322533129968081 1519 688837 SGTC_1147 3809-1045 12.3 µM 0.460154772612686 0.281395937583783 no 947 0.322702565839835 1498 325925 SGTC_1107 amlodipine 47 µM 0.460130499430144 0.281403403135773 no 948 0.322711276677734 1482 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2258 7960471 200 µM 0.460106050468447 0.281410922847687 no 949 0.322720050695275 1494 2974708 SGTC_563 tetrahydrosecaminediol 614 µM 0.458225759468173 0.281989530008604 no 950 0.323395127532705 1640 334274 A psychoactive constituent of the cannabis plant. SGTC_1834 st055981 52.8 µM 0.456392753263332 0.28255413758855 no 951 0.324053787956142 1634 471719 YDL150W RPC53 SGTC_428 3448-4153 16.5 µM 0.455479331722169 0.282835694936127 no 952 0.324382216760786 1468 3834874 SGTC_727 3032-0951 202 µM 0.451719378066296 0.283996097587667 no 953 0.325735578187413 1578 3652836 SGTC_1017 4239-0030 168 µM 0.451685990539728 0.284006411892394 no 954 0.325747606054123 1471 1149593 SGTC_1575 cyproterone acetate 48 µM 0.449961906356515 0.284539271288005 no 955 0.326368954191205 1487 9880 An androgen receptor antagonist and liver toxin. SGTC_2201 6605497 169.863 µM 0.448256095565859 0.285066952423614 no 956 0.326984191300064 1612 670741 SGTC_3050 9093513 49.47 µM 0.447563889432184 0.285281214745241 no 957 0.327233984546749 1533 25236664 SGTC_2044 5102272 200 µM 0.445640033980296 0.285877118772517 no 958 0.327928643622473 1551 592666 SGTC_1737 st035557 69.7 µM 0.441320083842977 0.287217352656878 no 959 0.329490644199323 1515 5716916 SGTC_1668 st014914 51.6 µM 0.440355279701986 0.28751708206124 no 960 0.329839904545872 1565 2839556 SGTC_1442 4112-3290 3 µM 0.43942040239631 0.287807655299456 no 961 0.330178472924877 1554 704353 SGTC_684 1140-0066 328 µM 0.437180809536841 0.288504316405526 no 962 0.330990112977165 1563 6813534 SGTC_1443 4112-3303 14 µM 0.435701020391602 0.288965064005344 no 963 0.331526832655523 1574 704433 SGTC_92 0063-0024 660.874 µM 0.435266981186853 0.289100272220005 no 964 0.331684324419787 1573 3594437 SGTC_1077 5-fluorocytosine 377 nM 0.434126497699612 0.289455687694752 no 965 0.332098292288203 1574 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1405 3909-7894 12 µM 0.433181814013039 0.289750240260722 no 966 0.332441344830995 1664 7104060 SGTC_3331 9141060 1.957 µM 0.432586946521703 0.289935792203904 no 967 0.332657437143389 1534 4906567 YPR165W RHO1 SGTC_1899 st063254 59.6 µM 0.432502258486237 0.289962212750864 no 968 0.332688205549376 1503 3093813 SGTC_787 4152-0075 138 µM 0.430222341580865 0.290673913656011 no 969 0.333516955804912 1610 9566539 SGTC_2438 5259590 200 µM 0.429874296642521 0.290782631521049 no 970 0.333643541851727 1699 1201127 SGTC_3007 9078383 71.4286 µM 0.429612478320049 0.290864427537432 no 971 0.333738779241316 1583 6496995 SGTC_2514 salinomycin 42.74 µM 0.428253493384427 0.29128916774486 no 972 0.334233287068795 1737 23682228 A polyether potassium ionophore. SGTC_1241 0364-0022 50.8 µM 0.42816164194175 0.291317885642499 no 973 0.334266720392704 1638 4563895 SGTC_2565 isoliquiritigenin 100 µM 0.428094469140926 0.291338888453046 no 974 0.334291171684938 1495 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_199 4063-0024 41.6 µM 0.427645519956623 0.291479278805544 no 975 0.33445460986249 1657 306215 SGTC_2957 9076800 11.52 µM 0.426227702504176 0.291922849824388 no 976 0.334970966624682 1544 16459615 SGTC_1706 st031321 9.9705 µM 0.426101667284955 0.291962295759741 no 977 0.335016882672537 1664 6103185 SGTC_1988 st071872 53.4 µM 0.424291103738077 0.292529231512833 no 978 0.335676763199869 1645 16414116 SGTC_2343 7990716 14.84 µM 0.422043750979969 0.293233648394166 no 979 0.336496541722001 1629 6456862 SGTC_2084 5306078 60.6385 µM 0.422001739995945 0.293246823925043 no 980 0.336511873704045 1630 679340 SGTC_2375 9072683 200 µM 0.421441909988584 0.293422424614381 no 981 0.336716210580409 1743 16798029 SGTC_3071 9117417 49.47 µM 0.419486047105616 0.294036298030474 no 982 0.337430474910729 1696 45595590 YGL055W OLE1 SGTC_1720 st037298 9.481 µM 0.418877736882612 0.294227345202195 no 983 0.33765274421119 1578 597396 SGTC_157 1348-1695 65.819 µM 0.417150225850186 0.294770203310618 no 984 0.338284264747937 1585 5380510 SGTC_1721 st082152 9.2685 µM 0.41615518881918 0.295083096109881 no 985 0.338648223901916 1542 5296051 SGTC_619 1652-1634 108 µM 0.415707401833948 0.295223954150206 no 986 0.338812062154861 1590 5400454 SGTC_2516 gossypol 71.55 µM 0.41562317879713 0.295250451214061 no 987 0.338842881455258 1732 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2046 4110841 106 µM 0.414698607555461 0.295541398714587 no 988 0.339181275916882 1643 44119630 YMR134W ERG29 SGTC_98 0074-0023 107.663 µM 0.413220591494019 0.296006779893474 no 989 0.339722501455908 1552 3563821 SGTC_837 0091-0265 12.5 µM 0.412473922371551 0.296242010549663 no 990 0.339996045367692 1577 759367 SGTC_2731 amoxapine 43.43 µM 0.412188016015021 0.296332105189461 no 991 0.34010081012 1708 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2187 6125751 200 µM 0.412007121334161 0.296389115101244 no 992 0.340167101790169 1635 874498 SGTC_2867 9039098 71.43 µM 0.409675039329486 0.297124532825826 no 993 0.341022171325582 1586 6463460 SGTC_2168 5727979 200 µM 0.409534785809459 0.297168788097392 no 994 0.341073622074389 1536 695210 SGTC_1748 st037455 53.6035 µM 0.407805398017751 0.297714722591243 no 995 0.341708275134921 1664 580690 SGTC_520 3584-0023 682 µM 0.407108458259795 0.2979348623672 no 996 0.341964165694727 1589 1340790 SGTC_2992 9074591 71.4286 µM 0.401748246990321 0.299630446791794 no 997 0.343934656614371 1624 17741321 SGTC_2033 5192550 145 µM 0.401079384945219 0.299842332995434 no 998 0.344180839021508 1595 182073 SGTC_2646 retinol 96.75 µM 0.400925220723179 0.299891179697096 no 999 0.344237590315268 1640 445354 A vitamin A analog and teratogen. SGTC_847 0342-0274 5.54 µM 0.39776728286228 0.30089255907466 no 1000 0.345400868036194 1743 18097 SGTC_166 k072-0058 166.424 µM 0.39653912103088 0.301282415005548 no 1001 0.345853676838084 1683 5846229 SGTC_712 r015-0009 80.6 µM 0.396253525020342 0.301373104457331 no 1002 0.345959004354884 1700 6813872 YLR060W FRS1 SGTC_451 chloral hydrate 100 µM 0.391675063925379 0.302828644124944 no 1003 0.347649158495881 1680 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3051 9093778 49.47 µM 0.390856533919845 0.303089194527775 no 1004 0.347951642088209 1655 17217378 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.389997171660469 0.303362850307105 no 1005 0.348269319180019 1775 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2737 bleomycin 30.5 nM 0.389989454139528 0.303365308378797 no 1006 0.348272172568605 1647 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_946 3434-1334 87.4 µM 0.388651792390151 0.30379149518867 no 1007 0.348766874061131 1705 4047976 SGTC_937 3122-0005 46.7 µM 0.388345702325322 0.303889054807317 no 1008 0.348880110183072 1756 759535 SGTC_184 1494-0393 24.714 µM 0.388078584538079 0.303974204267501 no 1009 0.348978939752132 1602 3090647 SGTC_2489 cantharidin 73.42 µM 0.38681218968027 0.304378039168031 no 1010 0.349447626154948 1596 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1574 spiramycin 23.7 µM 0.385093105505293 0.30492661191461 no 1011 0.350084217940095 1588 6419898 An antibiotic and protein synthesis inhibitor. SGTC_17 0960-0276 49.807 µM 0.385019226957966 0.30495019695816 no 1012 0.350111585266464 1662 6821114 SGTC_3243 9134147 49.47 µM 0.384307791133309 0.305177357733077 no 1013 0.350375167040423 1697 24282180 SGTC_1763 st044482 94.5 µM 0.384261698548203 0.305192077641445 no 1014 0.350392246493687 1706 88505 SGTC_2643 anethole 100 µM 0.384006723769439 0.30527351086412 no 1015 0.350486732009588 1654 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1872 amphotericin b 148 nM 0.382823376812485 0.305651571452682 no 1016 0.350925363650149 1725 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2626 ethyl orsellinate 100 µM 0.382520455825408 0.305748383241527 no 1017 0.351037679452635 1623 75653 A natural product. SGTC_2845 9003024 42.97 µM 0.381278405335698 0.306145477283506 no 1018 0.351498337837649 1736 2990173 SGTC_2110 5483698 200 µM 0.380880738372472 0.306272662955676 no 1019 0.35164587285012 1666 2848765 YHR062C RPP1 SGTC_2057 5236571 38.335 µM 0.379843236218058 0.306604596764666 no 1020 0.352030892794446 1765 54684039 YBR257W POP4 SGTC_575 k072-0246 11.9 µM 0.378044073851379 0.307180588865203 no 1021 0.352698926539075 1667 6796779 SGTC_3280 9140961 49.47 µM 0.377881540527723 0.307232646495775 no 1022 0.352759298004915 1647 4901226 SGTC_2289 7946404 165.07 µM 0.377062731755084 0.307494960977435 no 1023 0.353063493145049 1619 1246120 YPR165W RHO1 SGTC_2507 purpurin 79.67 µM 0.376916839504973 0.3075417095198 no 1024 0.35311770334887 1571 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1951 sophoraflavanone G 9.2 µM 0.376839404737532 0.307566523365462 no 1025 0.353146477538117 1621 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2266 7929956 200 µM 0.376461629285301 0.307687593521417 no 1026 0.353286868151498 1626 2967153 SGTC_1177 0983-0204 23.6 µM 0.375203414794355 0.308090979364049 no 1027 0.353754595385237 1813 766818 SGTC_117 lucigenin 22.078 µM 0.374313935028287 0.308376288163465 no 1028 0.354085382882031 1585 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_947 3447-0010 211 µM 0.37393354676698 0.308498336543512 no 1029 0.354226878627071 1634 748350 SGTC_1182 1222-0449 220 µM 0.372775271662245 0.308870101860264 no 1030 0.354657854392587 1676 658318 SGTC_572 0960-0087 17.7 µM 0.370009673720435 0.309758552729052 no 1031 0.355687641277613 1591 6796365 SGTC_1491 4138-0063 26.5 µM 0.368042118475278 0.310391309318877 no 1032 0.356420914465078 1766 23883227 SGTC_2019 4016004 108 µM 0.364723285667091 0.311459902408289 no 1033 0.357658987398207 1637 45595336 SGTC_1159 4092-0538 61.2 µM 0.363457871954079 0.311867757796647 no 1034 0.358131438771363 1711 717301 SGTC_2904 7225135 42.03 µM 0.362170539745698 0.312282914597163 no 1035 0.358612296591082 1739 4446116 SGTC_65 0798-0905 34.986 µM 0.361222436473059 0.312588824642216 no 1036 0.358966585495047 1856 3602145 SGTC_2013 4024628 200 µM 0.359735770067783 0.313068764662538 no 1037 0.359522369853909 1717 5230760 SGTC_672 1441-0018 53.7 µM 0.358143335761969 0.313583201238952 no 1038 0.360118024894045 1639 251141 SGTC_3353 9151644 39.2805 µM 0.357824956132324 0.313686097459223 no 1039 0.360237156595187 1702 4909158 SGTC_414 piperonyl butoxide 100 µM 0.356071162974616 0.314253160629667 no 1040 0.360893636206282 1647 5794 A potent inhibitor of cytochrome P450. SGTC_1940 st075990 51.1 µM 0.35603850789101 0.314263723333852 no 1041 0.360905863547009 1757 1084979 SGTC_2404 5161160 200 µM 0.35580347511705 0.314339752175398 no 1042 0.36099387320486 1737 2831543 SGTC_3187 9109394 49.47 µM 0.355585725822487 0.314410197153943 no 1043 0.361075417511863 1627 17098090 SGTC_2989 9073649 71.4286 µM 0.354353038635615 0.314809116273451 no 1044 0.361537161939203 1824 21367202 SGTC_2666 tannic acid 100 µM 0.351792292164374 0.315638509256123 no 1045 0.362497019749677 1723 16134267 A thiamine antagonist. SGTC_2154 5570129 200 µM 0.350495672966705 0.316058822337566 no 1046 0.362983368468931 1706 673366 SGTC_3024 9090631 49.47 µM 0.348924204099744 0.31656854971908 no 1047 0.363573106781763 1848 25236383 SGTC_3258 9138477 49.47 µM 0.347719621654232 0.316959508551776 no 1048 0.364025379611706 1736 4970355 SGTC_2820 7989630 71.43 µM 0.346215747992824 0.317447892174226 no 1049 0.364590290272416 1854 2984098 SGTC_2826 7992541 19.48 µM 0.345671474525939 0.3176247236231 no 1050 0.364794812115489 1748 2985066 SGTC_1696 st025591 34.7925 µM 0.344768655569373 0.317918136279289 no 1051 0.365134149562935 1691 2787147 SGTC_1192 1488-0095 21.4 µM 0.343593301892069 0.318300292983901 no 1052 0.36557608134292 1722 915875 SGTC_1332 1480-0653 17.5 µM 0.343101743584324 0.318460176574066 no 1053 0.365760959733741 1830 5749438 SGTC_842 0271-0008 11.1 µM 0.342237835323675 0.318741252130724 no 1054 0.366085956986879 1767 1221709 SGTC_3070 9117005 49.47 µM 0.339803036807395 0.319533983134222 no 1055 0.367002430408364 1779 8779016 SGTC_2157 5649910 96.377 µM 0.339475473878544 0.319640695392925 no 1056 0.367125785144325 1665 2858091 SGTC_2733 amorolfine 100 µM 0.338868838480781 0.319838362298477 no 1057 0.367354270135808 1817 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_190 3970-0790 3.722 µM 0.338589971124741 0.31992924599021 no 1058 0.367459319345224 1805 2832352 SGTC_856 0433-0016 11.3 µM 0.338198264345447 0.320056922636051 no 1059 0.367606891865754 1725 3911780 SGTC_1372 2752-0194 270 µM 0.337959144477061 0.320134874125947 no 1060 0.367696988051221 1676 823334 SGTC_419 nsc-638432 893 µM 0.337389290808609 0.320320674641942 no 1061 0.367911728293454 1704 368090 SGTC_1663 st014140 55.4 µM 0.33593608326133 0.320794696123746 no 1062 0.368459533083119 1777 4207120 SGTC_603 3794-0023 45.9 µM 0.334782258728048 0.321171270161998 no 1063 0.368894672255054 1822 3802260 SGTC_3006 9075424 71.4286 µM 0.334452921150518 0.321278789924534 no 1064 0.369018905436258 1669 7465181 SGTC_2147 5545932 89.7195 µM 0.331638304385935 0.322198296085851 no 1065 0.370081196115978 1737 797404 SGTC_2056 5235370 200 µM 0.331132937309905 0.32236350978213 no 1066 0.370272036671376 1706 5511916 SGTC_2563 tomatine 8.54 µM 0.33070308110489 0.322504065221782 no 1067 0.370434387376431 1982 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3111 9122088 49.47 µM 0.328084478679995 0.323360849753499 no 1068 0.371423894644083 1831 16876704 SGTC_939 1165-0479 45.3 µM 0.327499051776791 0.323552524873997 no 1069 0.371645230014296 1850 1377347 SGTC_2119 5528445 120.635 µM 0.327148328983315 0.323667377755178 no 1070 0.371777849923637 1822 791935 SGTC_2294 7971431 200 µM 0.326582781247475 0.323852615771723 no 1071 0.371991734309239 1780 5741572 SGTC_3084 9116877 49.47 µM 0.325557801266198 0.324188446201932 no 1072 0.372379471928237 1840 27241325 SGTC_1250 0485-0349 40.2 µM 0.325551817309871 0.324190407240744 no 1073 0.372381735967364 1706 6842794 YDL195W SEC31 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.32467668104432 0.324477255974883 no 1074 0.372712892577882 1718 2724 A muscle relaxant with antifungal properties. SGTC_637 1181-0519 7.26 µM 0.320843551805569 0.325734889566145 no 1075 0.374164476579672 1725 6252091 YGR060W ERG25 SGTC_2788 5282734 71.43 µM 0.320281249128939 0.325919546073505 no 1076 0.374377568069695 1870 743706 SGTC_389 tpck 16.7 µM 0.319818169545328 0.326071650438635 no 1077 0.374553086574304 1753 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_351 caspofungin 25 nM 0.319545085764983 0.326161361839705 no 1078 0.374656604203469 1804 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2529 gangaleoidin 93.61 µM 0.31854954238003 0.326488495322918 no 1079 0.375034060404808 1747 4565183 SGTC_3194 9111903 49.47 µM 0.317859803607089 0.326715220345549 no 1080 0.375295642265677 1804 17087251 SGTC_611 3453-1652 23.7 µM 0.317549380073624 0.326817281001691 no 1081 0.375413388406891 1853 1560575 SGTC_730 1436-0052 41.2 µM 0.317307797070995 0.32689671732227 no 1082 0.375505030813648 1771 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2158 5657123 3.6195 µM 0.316720603447579 0.327089828596118 no 1083 0.375727806877786 1808 2858827 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.313675221827415 0.328092109794187 no 1084 0.37688386087184 1842 17037758 SGTC_342 k048-0088 23.3 µM 0.312632398807804 0.328435603800128 no 1085 0.377279980211287 1716 6820570 SGTC_1229 0139-0193 12.2 µM 0.311806345981974 0.328707799160884 no 1086 0.377593850465744 1870 3090752 SGTC_263 alizarin 107.927 µM 0.310067677042675 0.32928101051012 no 1087 0.378254745852695 1782 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1254 0550-0035 264 µM 0.309611052718353 0.329431618875159 no 1088 0.3784283750974 1846 15121435 SGTC_2591 skatole 100 µM 0.309185746405338 0.329571922517373 no 1089 0.378590117897679 1760 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_101 0490-5701 117.494 µM 0.309065428854006 0.329611618242989 no 1090 0.378635878186582 1860 4661669 SGTC_2663 amphotericin b 100 µM 0.308787785428154 0.329703226977946 no 1091 0.37874148060674 1785 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_907 3448-6986 75.5 µM 0.308282980048549 0.329869814209091 no 1092 0.378933507874987 1860 590582 SGTC_3291 9121177 71.43 µM 0.30749798206479 0.330128932845727 no 1093 0.379232179378421 1736 17015612 SGTC_631 k072-0230 41.5 µM 0.304849326638601 0.331003823805379 no 1094 0.380240455612115 1821 5773147 SGTC_671 0560-0003 407 µM 0.300519265393495 0.332436096254207 no 1095 0.38189055175049 1847 3238678 SGTC_918 glabranin 770.725 nM 0.299642724507979 0.332726332214186 no 1096 0.38222484563021 1818 124049 Also referred to as licorice root. SGTC_1328 1441-0025 69.2 µM 0.297522792610781 0.333428688026763 no 1097 0.383033704707007 1679 4562601 SGTC_566 0958-0068 16.5 µM 0.29740631781068 0.333467294314419 no 1098 0.383078160435424 1835 6815365 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.296462835108218 0.333780082431627 no 1099 0.383438322602059 1819 1377 SGTC_1611 st001856 99.4 µM 0.296311275453429 0.333830339025154 no 1100 0.383496187915675 1751 647478 SGTC_350 k064-0020 19.8 µM 0.296242280359694 0.333853218518005 no 1101 0.383522531029313 1904 2790705 SGTC_2934 9036370 36.88 µM 0.295753047454945 0.334015470967451 no 1102 0.383709341170456 1895 6462800 SGTC_692 k241-0027 77.8 µM 0.29511154617237 0.334228269730227 no 1103 0.38395433487477 1878 3600480 SGTC_2895 9054447 58.44 µM 0.294916350276863 0.334293030677748 no 1104 0.384028890723891 1784 2697450 SGTC_2580 diallyl disulphide 81.36 µM 0.294479712094098 0.334437913784424 no 1105 0.384195681950427 1793 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.292958796850579 0.334942768755878 no 1106 0.384776822969368 1749 16623 A steroid. SGTC_1197 1601-0112 267 µM 0.292652908079964 0.335044342023552 no 1107 0.38489373425103 1742 7350313 SGTC_2825 7998094 58.44 µM 0.292276394266461 0.33516938357175 no 1108 0.385037652930063 1787 2987815 SGTC_2232 chlorophetanol 41.5365 µM 0.291765210180407 0.335339178821976 no 1109 0.385233073333775 1883 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2453 5731132 22.18 µM 0.29163459517761 0.3353825693869 no 1110 0.385283010779452 1920 1362040 SGTC_3023 9089636 49.47 µM 0.291496876039237 0.335428322338255 no 1111 0.385335666377523 1907 17249241 SGTC_562 3772-2733 112 µM 0.290864728828957 0.335638365127142 no 1112 0.385577388936117 1892 2876874 YIL048W NEO1 SGTC_2423 st077119 87.2 µM 0.290140340038086 0.335879120069381 no 1113 0.385854437784263 1804 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2690 usnic acid 100 µM 0.287642281221053 0.336709881029099 no 1114 0.386810288140687 1924 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2197 6588183 93.1375 µM 0.28647536050088 0.337098228760143 no 1115 0.387257031248562 1852 884136 SGTC_1220 1838-0075 193 µM 0.285375592346134 0.337464387303835 no 1116 0.387678202447632 1843 5529645 SGTC_733 4069-0007 56.1 µM 0.284707505116878 0.337686896513961 no 1117 0.387934120134009 1840 5717425 YNL287W SEC21 SGTC_1064 honokiol 6.76 µM 0.283831378497661 0.337978780101055 no 1118 0.38826980321469 1824 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_916 4466-0038 42 nM 0.283379373750077 0.338129404630568 no 1119 0.388443019001106 1979 5722064 YGL116W CDC20 SGTC_991 3996-0057 64.7 µM 0.282918045485299 0.338283162819619 no 1120 0.388619830594838 1806 715343 SGTC_1968 st069590 43.6 µM 0.279894448251582 0.339291577938143 no 1121 0.38977924335731 1901 6384066 SGTC_1041 0206-0046 107 µM 0.279173668039565 0.33953213929817 no 1122 0.39005577522139 1799 50494 SGTC_1403 3909-7815 62.9 µM 0.277808038350575 0.339988099294661 no 1123 0.390579860139851 1814 6615483 SGTC_155 k072-0202 43.6 µM 0.277243694226885 0.340176592394349 no 1124 0.390796495455151 1930 5857737 SGTC_1125 tnp00248 1.32998 µM 0.277030342344917 0.340247863148917 no 1125 0.390878403878292 1977 24207736 SGTC_3226 9131256 49.47 µM 0.276410166965156 0.340455066757623 no 1126 0.391116524345642 1838 17178073 SGTC_206 4546-0025 72.014 µM 0.276035600773803 0.340580234478737 no 1127 0.391260361308228 1834 6620745 YIL048W NEO1 SGTC_1450 4112-4260 37.6 µM 0.275945204161362 0.340610444688849 no 1128 0.391295076691444 1924 1633175 SGTC_3175 9106517 49.47 µM 0.275693762665846 0.340694480874451 no 1129 0.39139164335761 1803 41468073 SGTC_1917 st066507 28.5 µM 0.272277070257993 0.341837182042303 no 1130 0.392704492854758 1781 3156428 SGTC_524 r073-0010 27.8 µM 0.271651426650631 0.342046583858318 no 1131 0.392945026521725 1770 2772106 SGTC_917 harmaline 728.087 nM 0.270060850073696 0.342579165716161 no 1132 0.393556720242967 1877 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2135 5326629 150.42 µM 0.268695864309625 0.343036461413634 no 1133 0.394081867295507 1788 5020077 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.268456482624866 0.343116682467704 no 1134 0.394173983803726 1867 676296 Flavone; oxidizing agent. SGTC_3173 9105693 49.47 µM 0.266056028645506 0.343921507674278 no 1135 0.395098029427941 1889 17096658 SGTC_374 0880-0231 82.3 µM 0.264922128131444 0.344301928651525 no 1136 0.395534725707916 1900 6833587 SGTC_1204 4049-0315 18.3 µM 0.263963257987169 0.344623750345661 no 1137 0.395904115384338 1936 588402 SGTC_2055 5235184 200 µM 0.262790611974758 0.345017473652384 no 1138 0.396355985928434 1850 2836034 SGTC_649 1123-0311 367 µM 0.262228896768863 0.345206132567969 no 1139 0.396572488134995 1938 693629 YIL048W NEO1 SGTC_2902 5787006 60.46 µM 0.261598238410168 0.345417992730939 no 1140 0.396815601140983 1798 591003 SGTC_3144 9087057 49.47 µM 0.261405315652323 0.34548281189997 no 1141 0.396889979108766 2036 17249618 SGTC_2035 5154463 94.595 µM 0.260563665391782 0.345765646817796 no 1142 0.397214506371618 1945 2769623 SGTC_2233 sulbentine 40.3845 µM 0.259328257598148 0.346180959092706 no 1143 0.397690989277386 1907 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1724 st037281 8.293 µM 0.259143382636602 0.346243125222964 no 1144 0.397762306622926 1788 574124 YDL195W SEC31 SGTC_64 000l-0018 272.079 µM 0.255754092664966 0.347383541931464 no 1145 0.399070361942226 1813 6811119 SGTC_3011 9081274 71.4286 µM 0.254512978230632 0.347801494369165 no 1146 0.399549639479166 1818 6625322 SGTC_3109 9122853 49.47 µM 0.250267738354583 0.349232499469607 no 1147 0.401190151897604 1921 1234709 SGTC_2669 eugenol 100 µM 0.249532123430608 0.349480682677267 no 1148 0.401474597843487 1974 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2112 5488546 200 µM 0.248138846470187 0.349950925510275 no 1149 0.402013490079987 1865 600757 SGTC_2059 5238311 157 µM 0.246742709082627 0.350422364710858 no 1150 0.402553675588548 1841 703021 SGTC_3297 9117502 71.43 µM 0.245213403057052 0.350939036033937 no 1151 0.403145599504718 1952 7453720 SGTC_1169 aniline yellow 25.8 µM 0.244575700445741 0.351154563410735 no 1152 0.403392490476239 1922 6051 A DNA damaging agent. SGTC_3063 1327-0034 4 µM 0.242822920042841 0.351747205424267 no 1153 0.404071289623589 1947 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2025 5147754 141 µM 0.242566739539016 0.351833854216684 no 1154 0.404170524880455 1982 315777 YLR208W SEC13 SGTC_1184 1269-1718 139 µM 0.236969237932211 0.353729030215765 no 1155 0.406340327595478 1992 5403821 SGTC_2729 fluphenazine 10.66 µM 0.23626734368312 0.353966931443039 no 1156 0.406612612807355 1891 3372 An atypical antipsychotic. SGTC_2037 5169046 200 µM 0.233256112583052 0.354988209288913 no 1157 0.407781267876188 1926 5718022 SGTC_2032 5185112 25.99 µM 0.231574390771391 0.355559030062231 no 1158 0.408434300028667 1964 5718189 SGTC_2618 avocadyne 43.43 µM 0.227115100026362 0.357074197259391 no 1159 0.410167121352714 1918 3015189 SGTC_2403 6032726 181.2 µM 0.226821430206762 0.357174059157114 no 1160 0.410281299536104 1884 2881040 SGTC_3141 9094609 49.47 µM 0.226008728328975 0.357450467965648 no 1161 0.410597315867832 1803 25236309 YDL196W YDL196W SGTC_656 4090-1979 187 µM 0.225706161210366 0.357553393471443 no 1162 0.410714982891593 2029 22330961 SGTC_1253 0550-0034 176 µM 0.224776031686261 0.357869864325872 no 1163 0.411076756457111 1907 5969915 SGTC_698 k064-0052 127 µM 0.224082572961529 0.358105872991612 no 1164 0.41134652623278 1955 5088751 SGTC_1486 3970-0793 4.53 µM 0.223806926760552 0.358199700264894 no 1165 0.411453769952765 2021 2844330 SGTC_3211 9128781 49.47 µM 0.223453847706912 0.35831989743449 no 1166 0.411591149589791 1792 17194361 SGTC_2295 7971645 200 µM 0.220708865110532 0.359254838007603 no 1167 0.412659564159088 1959 2978226 YKL099C UTP11 SGTC_2553 4-methylesculetin 85.09 µM 0.220232541741716 0.359417159691612 no 1168 0.412845027040551 1856 5319502 SGTC_2654 protoveratrine a 100 µM 0.219663865641809 0.359610986606773 no 1169 0.413066474171695 1954 5702278 A heart drug and vasodilator. SGTC_1481 3346-2004 36 µM 0.21706559785125 0.36049703610032 no 1170 0.414078611852133 2021 2770522 SGTC_1318 1280-3875 124 µM 0.216401686816406 0.360723560460415 no 1171 0.414337325765671 1952 373245 SGTC_460 trequinsin 123 µM 0.216318170382837 0.360752059467724 no 1172 0.414369873217438 2019 5537 A vasodilator. SGTC_397 arbidol 50 µM 0.216027656345764 0.360851200011639 no 1173 0.414483094934558 2007 131410 A RNA synthesis inhibitor. SGTC_1158 4092-0494 91.8 µM 0.214779116001163 0.361277382076869 no 1174 0.414969767973237 1996 1148199 SGTC_1665 st014639 11.4 µM 0.213361736570904 0.361761405109626 no 1175 0.415522411561113 1980 981133 YIL048W NEO1 SGTC_254 nsc-64875 3.808 µM 0.213274935940363 0.361791053984457 no 1176 0.415556261019408 2034 56993 SGTC_2958 9077254 16.72 µM 0.212836352902237 0.36194087541335 no 1177 0.415727303896416 1925 16457351 SGTC_1526 st051518 75 µM 0.212237241692185 0.362145567991698 no 1178 0.41596097690709 1873 673993 SGTC_487 nimodipine 119 µM 0.211311839356961 0.362461818800226 no 1179 0.416321972519638 2047 4497 L-type voltage-gated calcium channels inhibitor SGTC_3251 9135047 49.47 µM 0.21123923293174 0.362486635593655 no 1180 0.41635029897567 2027 17682963 SGTC_6 0844-0013 19.835 µM 0.210828963813895 0.362626875965087 no 1181 0.416510368315312 2029 1584900 SGTC_2274 7947094 46.08 µM 0.210569493269586 0.362715579082128 no 1182 0.4166116096955 2083 2971028 SGTC_936 3005-4620 401 µM 0.2099879397865 0.362914416871278 no 1183 0.416838542923878 2060 777207 SGTC_2596 sinensetin 100 µM 0.208711925603258 0.36335082579311 no 1184 0.417336564939439 1912 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_954 1189-0853 2.85 µM 0.208577842686577 0.363396693730222 no 1185 0.417388904552906 2024 2828194 SGTC_3268 9137683 49.47 µM 0.208508210690651 0.363420514659084 no 1186 0.41741608616022 1912 1953228 SGTC_3013 9080133 71.4286 µM 0.208505313398751 0.363421505826726 no 1187 0.417417217158194 1982 17050193 SGTC_1884 5633444 25 µM 0.207618193325808 0.36372503382626 no 1188 0.417763548839263 1964 5724239 SGTC_468 gf-109203x 121 µM 0.206827666754723 0.363995584462365 no 1189 0.418072224177617 2051 2396 A protein kinase C inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.204704475414489 0.36472256296503 no 1190 0.418901511789946 1824 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1784 st039334 36.3 µM 0.204501754663837 0.364791999832495 no 1191 0.418980710472739 2051 3496984 SGTC_133 0724-0033 378.92 µM 0.2042281260252 0.364885731437369 no 1192 0.41908761656461 2055 280309 SGTC_348 k064-0012 10.7 µM 0.20410059969062 0.364929418395904 no 1193 0.419137442857362 1914 5066323 SGTC_2847 9005661 71.43 µM 0.203146679910453 0.365256260236478 no 1194 0.419510193514708 2063 2991449 SGTC_1841 st054148 70 µM 0.202818469198297 0.3653687378256 no 1195 0.419638460808191 1910 675442 SGTC_1146 3579-1023 7 µM 0.201279341546932 0.365896350170867 no 1196 0.42024007752939 2061 X1146 SGTC_2515 chrysin 20.77 µM 0.201159633785795 0.365937396590797 no 1197 0.420286876924312 2026 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_535 2293-4129 48.2 µM 0.200869935221516 0.366036737259324 no 1198 0.420400138383091 2054 396118 YIL048W NEO1 SGTC_1330 1469-0054 61.8 µM 0.200177641359013 0.366274168431394 no 1199 0.42067082643965 2076 7102664 SGTC_143 4032-1194 15.74 µM 0.199791062139747 0.366406773080807 no 1200 0.420821995891171 1904 1806963 SGTC_1199 1638-0010 4.46 µM 0.197953079111737 0.367037457155813 no 1201 0.42154088732503 1893 3111136 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.197840378616751 0.367076140814763 no 1202 0.421584976475087 1924 688788 SGTC_3077 9117319 49.47 µM 0.196123615275717 0.367665574500261 no 1203 0.422256706434578 2047 17154678 SGTC_167 3672-0051 66.205 µM 0.194967504146008 0.368062689609484 no 1204 0.422709193671865 1973 3237971 SGTC_2302 7771753 200 µM 0.194408298605986 0.368254822962757 no 1205 0.422928096267636 1881 2203047 SGTC_3085 9117376 49.47 µM 0.194327624490204 0.368282543914917 no 1206 0.422959678345134 1973 16480349 SGTC_2107 5363541 170.161 µM 0.193899039239475 0.368429824346442 no 1207 0.423127467999303 2056 244052 SGTC_1803 st050068 52.4 µM 0.193880936338729 0.368436045711918 no 1208 0.423134555529933 2033 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_630 4356-0227 183 µM 0.193196439200586 0.36867130992946 no 1209 0.423402563655665 2017 779312 SGTC_852 0418-0143 439 µM 0.192690676243256 0.368845174174744 no 1210 0.423600612946644 2064 5369229 SGTC_1285 0929-0069 65.5 µM 0.19183565268024 0.369139163472045 no 1211 0.423935471395866 1954 1206237 SGTC_3104 9120930 49.47 µM 0.190657394509917 0.36954441841951 no 1212 0.424397010274631 1989 17014836 SGTC_1969 st069479 40.1 µM 0.190620806524259 0.369557004964431 no 1213 0.424411343922329 2066 3895485 SGTC_1414 3917-0015 5.4 µM 0.190230768925579 0.369691189545825 no 1214 0.424564150605181 2043 6618702 SGTC_1198 1612-1005 86.7 µM 0.188962752845729 0.370127534531556 no 1215 0.425061004869588 2057 6998509 SGTC_2094 5332512 191.667 µM 0.187869861549984 0.370503750417884 no 1216 0.425489334513279 2049 755774 SGTC_1232 0279-0259 161 µM 0.187687622681627 0.370566496217349 no 1217 0.425560766754669 1913 1560000 SGTC_2365 9042475 200 µM 0.186846808022382 0.370856037687201 no 1218 0.425890372815954 1954 6464479 SGTC_3215 9129942 49.47 µM 0.18667882161493 0.370913893964931 no 1219 0.425956231043179 2101 17682944 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.186548159089992 0.370958897524576 no 1220 0.426007458057812 2006 5393153 SGTC_2921 7974240 10.71 µM 0.184430049649194 0.371688675122786 no 1221 0.426838048960938 2019 2979074 YDR527W RBA50 SGTC_2990 9074105 71.4286 µM 0.183352004408948 0.372060284285926 no 1222 0.427260916161258 2043 6502001 SGTC_2284 7945075 39.21 µM 0.182344154610592 0.372407804446244 no 1223 0.427656324556883 2103 1245402 SGTC_605 1315-0399 119 µM 0.182046402718823 0.372510493199775 no 1224 0.427773155091788 2031 24020461 SGTC_741 4582-0002 126 µM 0.179404566776379 0.373422006492673 no 1225 0.428810022897257 1947 2912688 SGTC_1518 st038567 90.8 µM 0.177981273255878 0.373913379897921 no 1226 0.429368841351087 2089 77966 SGTC_484 loperamide 105 µM 0.176932877214742 0.374275456019351 no 1227 0.429780556865153 2027 3955 An opioid-receptor agonist. SGTC_496 calpeptin 138 µM 0.176804407574504 0.374319832182468 no 1228 0.429831013427848 1969 73364 A calpain inhibitor. SGTC_1052 3253-3998 198 µM 0.175931061965758 0.374621548553179 no 1229 0.430174051010258 2085 5450317 SGTC_3121 9125696 49.47 µM 0.174324296699038 0.375176841252856 no 1230 0.430805302787685 2141 1235365 SGTC_1161 k007-0610 110 µM 0.174300049502794 0.375185222987721 no 1231 0.43081483017086 2112 5843850 SGTC_275 trichlorophene 5.69 µM 0.173815002698721 0.375352905624742 no 1232 0.431005426710434 2007 62616 SGTC_3245 9134821 49.47 µM 0.168455558533444 0.377207248508368 no 1233 0.433112451567425 1958 17014901 SGTC_2945 9067681 61.76 µM 0.1644443949545 0.37859695020653 no 1234 0.43469065855734 2106 16456930 SGTC_2475 5812728 15.03 µM 0.164401366088688 0.378611866473248 no 1235 0.434707594111582 2119 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_124 0136-0217 7.121 µM 0.162361699761826 0.379319138612835 no 1236 0.435510514883222 2170 3976905 SGTC_554 4483-2211 187 µM 0.161312289183659 0.379683188505259 no 1237 0.435923722324972 2014 747107 SGTC_3241 9133421 49.47 µM 0.159130625597382 0.380440368143439 no 1238 0.436782979953312 2124 17018221 SGTC_510 ag-490 170 µM 0.158128002575873 0.380788497650874 no 1239 0.437177967668131 2163 5328779 SGTC_2773 thioridazine 9.09 µM 0.155194832997288 0.38180750247869 no 1240 0.438333860804025 2164 5452 An antipsychotic. SGTC_2222 6885208 172.143 µM 0.1531091497334 0.382532583291296 no 1241 0.43915610025595 2072 609514 SGTC_2418 pentamidine 31.67 µM 0.152706940936148 0.382672457299086 no 1242 0.439314693446728 2156 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1510 1123-0200 71.5 µM 0.152408532607322 0.382776243063068 no 1243 0.439432363825006 2107 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_58 0957-0393 9 µM 0.15229495437668 0.382815747535376 no 1244 0.439477152163123 2018 6997992 SGTC_2638 epoxomicin 18 µM 0.151976445642706 0.382926536881665 no 1245 0.439602756743822 2138 9915668 A protesome inhibitor. SGTC_2691 st077356 60.2 µM 0.150964397239617 0.383278629005272 no 1246 0.440001900426351 2081 2839272 SGTC_1629 st005085 44.9 µM 0.149855169543092 0.383664640613121 no 1247 0.440439440871889 1996 24207091 SGTC_900 1112-0045 141 µM 0.148518173902446 0.384130069000453 no 1248 0.440966922153177 2149 56211 YIL048W NEO1 SGTC_1042 0350-0096 82 µM 0.147610382160683 0.384446180339105 no 1249 0.44132513054281 1947 3122515 SGTC_738 1315-0003 72.4 µM 0.147245674128961 0.384573200663176 no 1250 0.441469055361387 2135 6251474 SGTC_667 1498-1044 59 µM 0.146918688503137 0.384687093584274 no 1251 0.441598100349757 2042 6739982 SGTC_1162 k048-0130 20.1 µM 0.146405568562587 0.384865839326051 no 1252 0.44180061580102 2014 6797406 SGTC_2385 9074692 200 µM 0.145197949349478 0.385286610956682 no 1253 0.442277292479768 1995 17046906 SGTC_2801 7907800 81.82 µM 0.144888177829613 0.385394566658945 no 1254 0.442399580332078 2028 6620925 SGTC_2170 morpholine 200 µM 0.144390442223311 0.385568046639569 no 1255 0.442596081861911 2108 121171 Reacts with secondary amines. SGTC_2136 5328288 199.296 µM 0.143664557352091 0.385821086437616 no 1256 0.442882679968127 2031 262395 SGTC_1339 1486-1321 22.7 µM 0.141494237261077 0.386577938499122 no 1257 0.443739756121696 2035 3469382 SGTC_2502 avocadyne acetate 18.59 µM 0.140741816852965 0.386840429708808 no 1258 0.444036954398872 2174 3952079 SGTC_1119 parthenolide 318.541 nM 0.140725550087987 0.386846105144061 no 1259 0.444043379950926 2090 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_452 diindolylmethane 8 µM 0.139250826193675 0.387360733161782 no 1260 0.444625973104235 2103 3071 Inhibits expression of several cancer promoting factors. SGTC_2608 thymoquinone 42.66 µM 0.138860513067054 0.387496972220436 no 1261 0.444780187301399 2181 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_957 1187-1561 14.1 µM 0.137437055206452 0.387993948428293 no 1262 0.445342671557376 2169 1538454 SGTC_1196 1588-0294 184 µM 0.135833686431406 0.388553957215471 no 1263 0.445976379968073 2021 6144269 SGTC_1482 3346-2049 8.48 µM 0.135749735563706 0.388583285138054 no 1264 0.446009564155877 2151 3826804 SGTC_2728 chlorpromazine 9.18 µM 0.134825954518456 0.388906046513155 no 1265 0.446374742230733 2181 2726 A thorazine and dopamine antagonist. SGTC_2483 5729050 27.16 µM 0.134075413797876 0.389168335644843 no 1266 0.446671470516715 2161 2865180 SGTC_3202 9113761 49.47 µM 0.133582602656113 0.389340584301393 no 1267 0.446866320973525 2155 4798415 SGTC_3116 9124943 49.47 µM 0.133518727439223 0.389362911729125 no 1268 0.446891577258145 1957 41905195 YPL160W CDC60 SGTC_441 propafenone 146 µM 0.133445623731983 0.389388465401577 no 1269 0.44692048275562 2134 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2498 4'-Methoxychalcone 54.63 µM 0.133284721310667 0.389444711125542 no 1270 0.446984105208044 1947 641818 YHR062C RPP1 SGTC_2627 acetyl isogambogic acid 100 µM 0.13296730545955 0.389555675129269 no 1271 0.447109618660323 2035 6857789 A caspase activator and apoptosis inducer. SGTC_1460 k062-0059 9.15 µM 0.130984038621322 0.390249200175176 no 1272 0.44789396697383 2134 1373085 SGTC_438 sphingosine 6.67 µM 0.130151875902942 0.390540301868472 no 1273 0.44822313404579 1937 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_645 0845-0943 5.41 µM 0.129867808373218 0.390639686562663 no 1274 0.448335506874927 2086 1885106 SGTC_130 0136-0219 337.655 µM 0.128694326774973 0.391050319911014 no 1275 0.448799762328508 2205 234244 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.128332097198339 0.391177098520108 no 1276 0.44894308260749 2078 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1974 st069448 26.9 µM 0.127225906260047 0.391564331550794 no 1277 0.449380800878163 2193 6323587 YNR016C ACC1 SGTC_1357 1503-1303 39.5 µM 0.127124794368554 0.391599732130648 no 1278 0.449420813798954 2145 292895 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.126642688830989 0.391768535849141 no 1279 0.449611604069165 2167 97141 SGTC_2486 5283202 22.39 µM 0.125725933586645 0.392089583366246 no 1280 0.449974436360315 2040 1377751 SGTC_1933 st074711 15.9 µM 0.125053730274359 0.392325035546245 no 1281 0.450240506773799 2187 17250958 SGTC_2908 7930301 100 µM 0.124860438496555 0.392392747022647 no 1282 0.450317019354289 2174 2223178 SGTC_2704 st078022 71.1 µM 0.124083726476342 0.39266486756322 no 1283 0.450624491482661 2197 54697681 SGTC_2439 5492030 7.2 µM 0.123193591051301 0.392976790444132 no 1284 0.4509769002559 2201 5722370 SGTC_2362 9071156 126 µM 0.122913870930194 0.393074824682142 no 1285 0.451087650752071 2160 653133 SGTC_3298 9116858 71.43 µM 0.122018708035166 0.39338860029752 no 1286 0.451442101054385 2151 2506942 SGTC_2595 hexamethylquercetagetin 100 µM 0.121623842811325 0.393527031855942 no 1287 0.451598464917949 2097 386331 SGTC_2113 5491891 107.031 µM 0.120918443963536 0.393774363551452 no 1288 0.451877816596775 2095 789979 SGTC_2976 9009005 19.48 µM 0.120553634847214 0.393902292201503 no 1289 0.452022297467105 2191 2993148 SGTC_2293 7624732 200 µM 0.120448476007201 0.3939391706775 no 1290 0.452063946293202 2167 894453 SGTC_1265 0819-1001 68.8 µM 0.115808549328847 0.395567303094989 no 1291 0.453902137362541 2203 3106768 SGTC_3283 9109332 35.8195 µM 0.114795195116957 0.395923128887419 no 1292 0.454303728810435 2213 17027281 SGTC_3247 9135149 49.47 µM 0.113397926899359 0.396413903165254 no 1293 0.454857541603029 2205 8934436 YOR116C RPO31 SGTC_3224 9130643 49.47 µM 0.112819304656121 0.396617185642494 no 1294 0.455086906577207 2149 17644395 SGTC_3093 9117344 49.47 µM 0.112198577863395 0.396835291600081 no 1295 0.455332978375872 2143 24824913 SGTC_2419 paclitaxel 166.5 µM 0.11139275497595 0.397118483265222 no 1296 0.455652452499491 2047 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_41 0478-0632 82.643 µM 0.110573012117279 0.397406622516102 no 1297 0.455977474717472 2235 3750424 SGTC_250 brefeldin a 552.239 µM 0.110185673036418 0.397542791520338 no 1298 0.456131062173107 2162 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_687 k029-0044 34.9 µM 0.108428861313383 0.398160554967157 no 1299 0.456827754037516 2216 5829338 SGTC_1681 tripelennamine 100 µM 0.107753571039958 0.398398081365604 no 1300 0.457095586655504 2237 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1962 st076595 64.5 µM 0.106792138055467 0.398736320453154 no 1301 0.457476942364789 2187 279619 SGTC_2214 7179297 48.276 µM 0.106178813943967 0.398952132076103 no 1302 0.457720239968158 2207 769744 SGTC_2092 5303694 80.6725 µM 0.102235237357878 0.400340501752396 no 1303 0.45928497945531 2117 1963699 SGTC_119 0121-0043 24.815 µM 0.102147694692843 0.400371336255503 no 1304 0.4593197220412 2225 1092378 SGTC_2314 7727897 200 µM 0.1018290524828 0.400483574478188 no 1305 0.459446182480081 2150 900724 SGTC_2215 7188065 200 µM 0.101670008977206 0.400539598883344 no 1306 0.45950930406382 2206 940217 SGTC_1568 digitonin 820 nM 0.100618889784775 0.40090991581008 no 1307 0.459926500463951 2245 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3025 9087895 49.47 µM 0.100181942671734 0.401063881676126 no 1308 0.460099940773345 2236 17173641 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0998228545861901 0.401190424073029 no 1309 0.460242481668721 2222 23665772 A membrane-active detergent. SGTC_1739 st037196 92.5 µM 0.0996982223397622 0.401234346815706 no 1310 0.460291955939693 2216 612214 SGTC_2678 equilin 100 µM 0.0996189434998775 0.401262286816287 no 1311 0.460323426949759 2244 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3309 9129340 25.759 µM 0.0983800325668226 0.401698977941474 no 1312 0.460815264729939 2174 17158987 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0978512146540381 0.401885413013383 no 1313 0.461025219532116 2211 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2344 7990960 76.95 µM 0.0970689629080305 0.402161237268681 no 1314 0.461335814224304 2135 140813 SGTC_2068 5226020 147 µM 0.0955608455091161 0.402693141295017 no 1315 0.461934681794464 2174 1810509 SGTC_719 2810-4230 27.3 µM 0.0950147859908038 0.402885777714674 no 1316 0.462151541266242 2238 721079 SGTC_146 3448-8650 53.125 µM 0.0947665406070139 0.402973360402181 no 1317 0.462250131977712 2122 2891488 YIL048W NEO1 SGTC_830 4076-0286 57.8 µM 0.094566473810338 0.403043948894122 no 1318 0.462329590240348 2174 6866659 SGTC_2096 5468907 200 µM 0.0885084203010811 0.405182865597929 no 1319 0.46473629608664 2230 759785 SGTC_2797 7859098 81.82 µM 0.0882946867150601 0.405258380658463 no 1320 0.464821230925589 2197 972681 SGTC_2331 7980721 200 µM 0.0869792922110714 0.40572320545612 no 1321 0.465343986068763 2210 2981221 SGTC_2255 7941087 197.44 µM 0.0856571900903063 0.406190534530317 no 1322 0.46586946717707 2266 935561 SGTC_617 3770-0098 35 µM 0.0849426284616365 0.406443169370389 no 1323 0.46615350080982 2158 5962639 SGTC_2205 7238770 200 µM 0.084444550087829 0.406619289121735 no 1324 0.466351493952322 2260 279867 SGTC_1472 k841-0093 193 µM 0.0827205041920203 0.407229054757055 no 1325 0.467036890379697 2237 X1472 SGTC_891 0929-0073 133 µM 0.0822536595819051 0.407394208491383 no 1326 0.467222501894628 2235 5603632 SGTC_1005 4092-0690 4.4 µM 0.0818102703740883 0.407551079746258 no 1327 0.467398794438158 2180 1529343 SGTC_2006 4011487 200 µM 0.0808426591444898 0.407893472382422 no 1328 0.467783540991843 2246 45595294 SGTC_1431 4049-0260 9.09 µM 0.0801969869474344 0.408121984913407 no 1329 0.468040293256356 2237 3854841 SGTC_462 ag-879 158 µM 0.0794014067600722 0.408403594975851 no 1330 0.468356674871738 2259 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2906 7926292 26.41 µM 0.0793589311396818 0.408418631325033 no 1331 0.468373566888588 2171 2966319 SGTC_867 0518-0118 155 µM 0.0786870339355353 0.408656500533453 no 1332 0.468640779460472 2283 6848158 SGTC_3178 9107506 49.47 µM 0.0786221817914992 0.408679461673279 no 1333 0.468666571816361 2229 8897194 SGTC_796 1234-0020 70.7 µM 0.0751162600330464 0.409921210654268 no 1334 0.470061105369561 2286 46495034 SGTC_779 1360-0071 233 µM 0.0747221422909831 0.410060858454673 no 1335 0.470217894960186 2298 7566 SGTC_2093 5331342 194.4 µM 0.0736339260796422 0.41044650545449 no 1336 0.470650837648062 2267 33839 SGTC_3112 9123419 49.47 µM 0.0732323647495487 0.410588834476865 no 1337 0.47081060608868 2292 17015854 SGTC_835 0312-0010 67.2 µM 0.0724981855152957 0.410849086710653 no 1338 0.471102724710082 2262 1626196 SGTC_560 2332-1943 155 µM 0.0722170786561627 0.410948744012645 no 1339 0.471214576929296 2287 21177716 SGTC_2840 9008771 71.43 µM 0.0721659778165843 0.410966860772344 no 1340 0.471234910161166 2271 2992978 SGTC_3147 9097027 49.47 µM 0.072156487867426 0.410970225261037 no 1341 0.471238686258784 2225 25236841 SGTC_962 1254-0300 21.5 µM 0.0719287885295191 0.41105095387892 no 1342 0.471329289723943 2234 7340576 SGTC_2400 5203494 178.7 µM 0.0716858768596501 0.411137080036371 no 1343 0.471425947938668 2275 6777674 SGTC_2523 spermine 47.74 µM 0.0700524870205572 0.411716321714266 no 1344 0.47207594180466 2269 1103 A DNA binding polyamine. SGTC_71 0417-1750 47.813 µM 0.0698476771239811 0.411788966128827 no 1345 0.472157449478486 2285 6811472 SGTC_329 k048-0121 21.3 µM 0.0679524270643902 0.41246133912914 no 1346 0.472911752200586 2185 6832902 SGTC_283 0987-0079 11.7 µM 0.0673093539754868 0.412689539008197 no 1347 0.473167715191513 2260 411556 SGTC_895 0964-0006 13.7 µM 0.0646655586891237 0.413628021206961 no 1348 0.474220142793913 2282 6738897 SGTC_3350 9150499 3.57 µM 0.0630466967540029 0.414202921322838 no 1349 0.474864659812358 2304 4910996 YPR165W RHO1 SGTC_223 busulfan 5 mM 0.0628439912451279 0.414274920317698 no 1350 0.474945367564952 2268 2478 A DNA alkylator. SGTC_322 k048-0136 19.3 µM 0.0621335775943936 0.414527274955742 no 1351 0.475228228796307 2244 6823282 SGTC_1926 methyl fluorone black 53.6 µM 0.0618986563120981 0.414610731958022 no 1352 0.475321768777776 2292 72721 Reacts with homocysteine. SGTC_979 1426-2828 121 µM 0.0607789740670664 0.415008557780829 no 1353 0.475767617810859 2247 747872 SGTC_910 3454-3003 490 µM 0.0588887263575845 0.415680364979503 no 1354 0.476520368766068 2303 820824 SGTC_2367 9070478 135.38 µM 0.0585850576845826 0.415788313974405 no 1355 0.476641306239957 2290 572802 SGTC_1327 1436-0082 2.18 µM 0.0572307058227462 0.416269840050318 no 1356 0.4771807092642 2156 15992205 SGTC_2066 5222451 176 µM 0.0551278784562515 0.417017727853818 no 1357 0.478018293057061 2308 2281147 SGTC_2505 galangin 7.89 µM 0.0540227106218129 0.417410910458231 no 1358 0.478458535100089 2277 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_748 act1.228 77.9 µM 0.0529072500728116 0.417807838627061 no 1359 0.478902903883116 2280 4421505 YNR035C ARC35 SGTC_3097 9117246 49.47 µM 0.0520413750160194 0.418116011450847 no 1360 0.479247862783576 2303 16423892 SGTC_3026 9090633 49.47 µM 0.0511637220165552 0.418428427462205 no 1361 0.479597529800629 2287 25236842 SGTC_2925 9010536 32.5 µM 0.0509991062297187 0.418487031082618 no 1362 0.479663116374223 2260 2994177 SGTC_1886 st057356 49.9 µM 0.050867967431306 0.418533718108624 no 1363 0.479715365368672 2283 24207747 SGTC_1713 st033146 12.748 µM 0.0501590617238955 0.418786117117752 no 1364 0.479997817238065 2318 674619 SGTC_1391 3442-0225 151 µM 0.0500512530944069 0.418824504267309 no 1365 0.480040772704258 2298 5227075 SGTC_3221 9128209 49.47 µM 0.0493553045122882 0.419072327525304 no 1366 0.480318073277554 2278 16460723 SGTC_1303 1160-0052 261 µM 0.0482962674152584 0.41944950608346 no 1367 0.480740064627776 2317 3562476 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0470912268116197 0.419878774153914 no 1368 0.481220259786043 2326 165521 SGTC_2323 6148992 148.28 µM 0.0464868474992537 0.420094106352729 no 1369 0.481461108464494 2274 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1667 st014849 34.6 µM 0.0458381564585393 0.420325252837813 no 1370 0.481719623151858 2315 5348460 SGTC_328 k915-0120 63.5 µM 0.0446710171048539 0.420741205886211 no 1371 0.482184767813912 2319 6624543 SGTC_1313 1220-0047 237 µM 0.0431623448965318 0.421279007813675 no 1372 0.482786060759136 2278 3528706 SGTC_235 0330-0087 5 mM 0.0411273505695886 0.422004662267266 no 1373 0.483597185221884 2322 46494818 YHR062C RPP1 SGTC_186 3455-3465 67.277 µM 0.0378840450695289 0.423161732455378 no 1374 0.484890067053707 2347 755278 SGTC_3301 9125354 19.7965 µM 0.0369969136435317 0.423478338230495 no 1375 0.485243733306512 2323 41905162 SGTC_1091 telmisartan 47.6 µM 0.0367473936410211 0.423567397616681 no 1376 0.485343209740195 2307 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1534 6-azauridine 81.6 µM 0.0335512597361772 0.42470851457895 no 1377 0.486617494729702 2354 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3145 9085516 49.47 µM 0.0334251674979231 0.424753546347131 no 1378 0.486667770055938 2241 25236195 SGTC_2947 9072639 7.68 µM 0.0327564318484297 0.424992390682706 no 1379 0.48693441094997 2338 16488146 SGTC_3246 9135460 32.98 µM 0.0327353308103817 0.424999927537386 no 1380 0.486942824534086 2344 41446951 SGTC_1203 3992-3522 103 µM 0.0318009106391374 0.425333710557703 no 1381 0.487315410210013 2355 5322312 SGTC_668 1682-0499 62.6 µM 0.0306744308030782 0.425736170099259 no 1382 0.487764591413699 2312 682214 SGTC_2224 6650123 117.647 µM 0.0300771089049404 0.425949607822485 no 1383 0.488002778458893 2346 2908370 SGTC_1745 st081495 74 µM 0.0297967585516571 0.426049791345229 no 1384 0.488114571960765 2342 13842402 YBL026W LSM2 SGTC_1487 3970-0795 2.82 µM 0.0294231260824358 0.426183316758231 no 1385 0.488263564420412 2294 3765103 SGTC_40 0327-0103 19.753 µM 0.0275564223899953 0.426850549003895 no 1386 0.489007969174486 2343 409036 SGTC_1684 st024538 14.6195 µM 0.0273888365978647 0.426910460930776 no 1387 0.489074801007216 2348 6732859 SGTC_3326 9140064 16.379 µM 0.0271965522032983 0.426979204686077 no 1388 0.489151482816831 2349 1868434 SGTC_710 3448-4187 58 µM 0.0237075911925919 0.428226929237654 no 1389 0.490542925406374 2354 3946412 SGTC_982 1491-0518 27.5 µM 0.0235207611120503 0.42829376389591 no 1390 0.490617439046252 2337 3091256 SGTC_2132 5317594 122.667 µM 0.0227349607803255 0.428574890465698 no 1391 0.490930844183377 2352 794577 SGTC_1587 estradiol valerate 56.1 µM 0.019409180332313 0.429765115612412 no 1392 0.492257343471352 2369 13791 A steroid. SGTC_138 0850-0259 40.9225 µM 0.0187058544711581 0.430016902952717 no 1393 0.492537878940166 2373 6813004 SGTC_371 0195-0006 7.36 µM 0.0176912560772773 0.430380174511943 no 1394 0.492942578098574 2344 3928593 SGTC_987 1497-1013 404 µM 0.016797840953842 0.430700105849527 no 1395 0.493298946162093 2364 1676435 SGTC_1777 st045864 34.765 µM 0.0165107490138915 0.430802922941911 no 1396 0.493413463392241 2378 4691462 SGTC_2762 leflunomide 42.06 µM 0.0163554150776954 0.43085855510348 no 1397 0.49347542430019 2379 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3159 9100096 49.47 µM 0.0158477724825885 0.431040374614568 no 1398 0.493677918141425 2381 25236875 SGTC_220 paclitaxel 373.376 µM 0.0139251334777347 0.431729127668417 no 1399 0.494444855028496 2368 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3079 9117512 49.47 µM 0.013052003882852 0.432041980315765 no 1400 0.494793151642859 2389 7185044 SGTC_2111 5486399 200 µM 0.0119509871740611 0.43243654834499 no 1401 0.495232359414583 2381 689674 SGTC_15 0266-0086 27.098 µM 0.0112641067905564 0.432682737750585 no 1402 0.495506366575935 2385 1712902 YIL048W NEO1 SGTC_1789 tunicamycin 25 nM 0.0109647911610628 0.432790025653996 no 1403 0.495625768860112 2377 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2171 5739187 198.077 µM 0.010414336334158 0.432987345835083 no 1404 0.495845356015127 2384 2262761 SGTC_1215 3852-0577 11.2 µM 0.00991628715520271 0.433165894693293 no 1405 0.496044038622722 2385 2884876 SGTC_2234 tolnaftate 200 µM 0.00980796032122954 0.433204731285455 no 1406 0.496087252675292 2378 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1616 st002734 56.1 µM 0.00959337845990666 0.433281663604022 no 1407 0.496172854424432 2382 4026101 SGTC_3022 9087993 49.47 µM 0.00877106075646681 0.433576505977796 no 1408 0.496500897885533 2396 17173644 SGTC_919 tnp00227 403.569 nM 0.00784602248247079 0.433908223033276 no 1409 0.496869922013431 2387 1269246 A methoxyflavone. YNL221C POP1 SGTC_950 1165-0508 94.1 µM 0.00780686427798064 0.433922266123366 no 1410 0.496885543398389 2372 6148369 SGTC_1729 st035615 45.989 µM 0.00578888610168636 0.434646074964463 no 1411 0.497690581476182 2321 17385451 SGTC_2665 lovastatin 100 µM 0.00564201519891435 0.434698763233807 no 1412 0.497749173532002 2388 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1001 4048-4355 44.4 µM 0.00441237534784475 0.435139927985803 no 1413 0.498239722628569 2391 21824233 SGTC_27 0485-0001 32.618 µM 0.00320076435869595 0.435574703410201 no 1414 0.498723081948029 2399 2054479 SGTC_1029 k015-0030 64.7 µM 0.0030265527746022 0.435637224046403 no 1415 0.498792581977674 2373 2208316 SGTC_2558 carylophyllene oxide 100 µM 0.0029233294264724 0.435674269353513 no 1416 0.498833761953322 2400 6708694 An oxygenated terpenoid and antifungal agent. SGTC_701 4424-0219 185 µM 0.00263813517120162 0.435776624215427 no 1417 0.498947537559608 2399 2911779 SGTC_149 3970-0822 46.1 µM 0.00263377857297045 0.435778187811191 no 1418 0.498949275584803 2402 3114250 YBL034C STU1 SGTC_1923 st058458 19.1 µM 0.00164213714283972 0.436134116874219 no 1419 0.499344882357937 2400 3534982 SGTC_50 0929-0078 56.389 µM 0.000864164128140949 0.436413390328141 no 1420 0.499655248434987 2399 1377751 SGTC_2572 astragaloside iv 100 µM 0.000618121529971657 0.436501720261437 no 1421 0.499753405202971 2403 45006101 An anti-inflammatory agent. SGTC_948 3448-0295 75.3 µM -0.00113351860505469 0.437130654889109 no 1422 0.49954779159966 2411 678569 SGTC_2348 9022543 33.42 µM -0.00298173052453302 0.437794436346317 no 1423 0.498810463387639 2415 3162678 YDL140C RPO21 SGTC_3306 9127676 59.7925 µM -0.00343357344804099 0.437956741496036 no 1424 0.498630205070229 2413 41905287 SGTC_387 norethindrone acetate 66.7 µM -0.00447799938300806 0.438331946527036 no 1425 0.498213542684991 2416 541197 SGTC_3346 9158254 43.5805 µM -0.00468657340165232 0.438406882399176 no 1426 0.498130334564091 2416 17639500 SGTC_3168 9103419 49.47 µM -0.00763230730749781 0.439465451783234 no 1427 0.496955179479257 2418 16649256 SGTC_703 3875-0075 71.8 µM -0.00777634908328755 0.439517225334172 no 1428 0.496897716830221 2421 2850814 SGTC_2247 cerulenin 830 nM -0.0081445605886201 0.439649577869136 no 1429 0.496750826347657 2430 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.00858761042428001 0.439808839760445 no 1430 0.496574081222759 2424 15053 SGTC_3016 9080866 49.47 µM -0.0100085048674654 0.440319670319782 no 1431 0.496007250903935 2419 17066299 SGTC_533 1222-0222 6.71 µM -0.0105070625680039 0.440498932071023 no 1432 0.495808365623871 2477 3982874 SGTC_2465 5809242 33.21 µM -0.0118166718564142 0.440969874089885 no 1433 0.495285939690076 2435 2731748 SGTC_1427 4048-4900 550 nM -0.0126560098171034 0.441271748143157 no 1434 0.494951117366921 2445 24132586 SGTC_1224 0823-0416 294 µM -0.0132129436554171 0.441472072326176 no 1435 0.494728951499331 2437 3598164 SGTC_1375 2910-0797 186 µM -0.0135524000113246 0.441594179127146 no 1436 0.494593540133612 2439 742508 SGTC_2888 9058547 12.99 µM -0.0139653566904835 0.44174273241932 no 1437 0.494428809848506 2437 16476514 SGTC_78 0336-0123 156.75 µM -0.0145852453427813 0.441965740920275 no 1438 0.494181535256536 2434 6765896 SGTC_2593 nobiletin 86.24 µM -0.0149151080243535 0.442084418416772 no 1439 0.494049953401487 2448 72344 An anti-infammatory. SGTC_901 1112-0062 60.1 µM -0.0152096305328661 0.442190385672467 no 1440 0.493932469248598 2418 1908457 SGTC_1295 1013-0063 9.78 µM -0.0165298721752996 0.442665450633785 no 1441 0.49340583539561 2435 6826038 SGTC_2644 guaiazulene 100 µM -0.0175339288121111 0.443026797399457 no 1442 0.493005332862318 2440 3515 A coloring agent. SGTC_2972 9093619 59.92 µM -0.0175983347609411 0.443049977873201 no 1443 0.492979642570144 2443 25236256 SGTC_3315 9136395 68.55 µM -0.0186850060991408 0.443441113252339 no 1444 0.49254619478384 2438 16876844 SGTC_636 0kpi-0074 126 µM -0.0191037138051731 0.44359183720887 no 1445 0.492379184391746 2465 616434 SGTC_2685 mycophenolic acid 18.85 µM -0.0192244767051371 0.4436353102501 no 1446 0.492331015811146 2454 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2803 7707263 71.43 µM -0.0193628394980602 0.44368511985302 no 1447 0.492275827315841 2451 2199229 SGTC_1233 0325-0408 14.2 µM -0.019990603668986 0.443911121570095 no 1448 0.492025434127528 2451 12874 SGTC_488 nitrendipine 139 µM -0.0200953156577339 0.443948820766661 no 1449 0.491983668477867 2428 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1493 4348-0038 111 µM -0.0220285342008462 0.444644923396957 no 1450 0.491212597028231 2446 800424 SGTC_681 1642-0006 26.6 µM -0.0222127053348383 0.444711247661637 no 1451 0.491139141350087 2439 4446530 SGTC_3158 9100007 49.47 µM -0.0227135617216002 0.444891625399275 no 1452 0.490939378968731 2454 19297233 SGTC_1819 st053448 58.6 µM -0.0229613360444936 0.444980862728154 no 1453 0.490840557089174 2455 2857616 SGTC_380 3970-0968 6 µM -0.0231515062317733 0.445049355492132 no 1454 0.490764710323805 2452 2891601 SGTC_2552 juarezic acid 87.02 µM -0.0251916814550876 0.445784259266269 no 1455 0.489951036044683 2443 1549512 SGTC_1367 1812-0510 76.9 µM -0.0282113676851203 0.446872339824006 no 1456 0.488746785366037 2471 1142582 YDR527W RBA50 SGTC_1755 st041960 45.185 µM -0.0295525704444132 0.447355742881712 no 1457 0.488211946038323 2480 2257073 SGTC_1417 3966-0327 90.4 µM -0.0317535218980126 0.448149190059729 no 1458 0.487334306039628 2464 651118 SGTC_2561 acetosyringone 100 µM -0.0318889551584131 0.448198020816073 no 1459 0.487280303334178 2446 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1938 st074717 56.4 µM -0.03206109505993 0.448260087364405 no 1460 0.487211664546599 2451 17250979 SGTC_108 0509-0257 621.132 µM -0.0322271837952349 0.448319973312365 no 1461 0.487145438950359 2470 536624 SGTC_2883 9059145 45.46 µM -0.0326966093432835 0.44848923856003 no 1462 0.486958263899614 2456 16476510 SGTC_743 1275-0778 158 µM -0.0336632111673464 0.448837804901173 no 1463 0.486572857785115 2503 2849257 YMR203W TOM40 SGTC_1778 st046819 58.9 µM -0.0346650180285359 0.449199108207735 no 1464 0.486173427860769 2470 671715 SGTC_1444 4112-3581 28 µM -0.0353201713184201 0.449435413130739 no 1465 0.485912219489357 2466 2877249 SGTC_279 1273-0055 2.93 µM -0.0361199323318552 0.449723900402535 no 1466 0.485593364497339 2463 2847562 SGTC_3188 9110789 49.47 µM -0.0375704909389139 0.450247209035156 no 1467 0.48501506806154 2497 849217 SGTC_2287 7945887 168.79 µM -0.037702370614323 0.450294790715495 no 1468 0.484962492932681 2474 1245853 SGTC_3017 9080681 49.47 µM -0.0380222241591424 0.45041019561236 no 1469 0.484834981260828 2522 16451914 SGTC_3343 9148379 18.9835 µM -0.0385373837534117 0.450596076804166 no 1470 0.484629612842552 2490 1955036 SGTC_171 k064-0041 9.68 µM -0.0387604151388538 0.450676554918278 no 1471 0.484540702622292 2475 53325 SGTC_151 3013-0144 2.285 µM -0.0390463185552903 0.450779722591883 no 1472 0.484426729941621 2569 906558 YHR107C CDC12 SGTC_1812 st052057 4.327 µM -0.0391167202029981 0.450805127395586 no 1473 0.484398665188495 2468 3645418 SGTC_1112 tnp00069 1.16933 µM -0.0397054005340056 0.451017563657959 no 1474 0.484163998035216 2572 145826 SGTC_471 1-acyl-paf 4 µM -0.0411099954859916 0.451524494475222 no 1475 0.483604103047897 2472 16759367 SGTC_3174 9107204 49.47 µM -0.0420182718912654 0.451852341655723 no 1476 0.483242066058505 2506 3938802 SGTC_1680 diphenhydramine 100 µM -0.0428380841734369 0.452148285444816 no 1477 0.482915302530427 2554 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1432 4049-0298 68.4 µM -0.0428872064444718 0.452166018924635 no 1478 0.48289572357316 2503 741646 SGTC_2499 avocadenofuran 51.48 µM -0.0433454877134304 0.452331466228004 no 1479 0.482713065661484 2494 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1178 0988-0033 191 µM -0.0447944356191012 0.452854615297141 no 1480 0.482135580187686 2550 5392207 SGTC_81 0411-0046 9.971 µM -0.0458883557517747 0.453249634284279 no 1481 0.48169961758265 2471 12925265 SGTC_1776 st049249 45.9 µM -0.0465406300982351 0.453485195232865 no 1482 0.481439675509756 2506 1822314 SGTC_2474 5321570 43.32 µM -0.0466653949993191 0.453530254426962 no 1483 0.481389955536894 2611 2841384 SGTC_1530 rhein 70.4 µM -0.0472158578942315 0.45372906278036 no 1484 0.481170594422861 2474 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_320 4092-0846 5.34 µM -0.0478333787752709 0.453952103980893 no 1485 0.480924517288857 2571 1359356 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0479093739084905 0.453979553524538 no 1486 0.480894234336252 2480 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3002 9075603 71.4286 µM -0.0502712629484181 0.454832779934887 no 1487 0.479953111825006 2490 20105405 SGTC_1354 1498-1681 81 µM -0.0516447201629217 0.455329033955161 no 1488 0.479405892662831 2550 5754243 SGTC_313 3474-0040 5.03 µM -0.053324748568904 0.455936152202259 no 1489 0.478736580872127 2492 1043375 YIL048W NEO1 SGTC_3057 9095946 49.47 µM -0.053606802707237 0.456038089304155 no 1490 0.478624218265447 2487 24540043 SGTC_1475 4092-1048 11.7 µM -0.0536425846248769 0.456051021443301 no 1491 0.478609963855415 2538 2881759 SGTC_97 0535-0701 19.132 µM -0.0536999326958648 0.456071748021337 no 1492 0.478587118213533 2515 2832013 YGL099W LSG1 SGTC_1839 st053978 48 µM -0.0539449000167423 0.456160284764581 no 1493 0.47848953184124 2485 3788398 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0544843452948845 0.456355260186007 no 1494 0.478274640353848 2526 4330530 SGTC_1990 st072050 59.8 µM -0.0551371631130595 0.456591226675295 no 1495 0.478014594640019 2490 17233948 SGTC_323 4013-0906 34.3 µM -0.0565994467771408 0.457119836825719 no 1496 0.477432137624044 2598 2910086 SGTC_2824 7998404 51.95 µM -0.0567906824634838 0.457188973451412 no 1497 0.477355968138726 2510 837851 SGTC_2315 7733312 200 µM -0.0568909598025267 0.457225226809993 no 1498 0.477316027841707 2535 726316 SGTC_1788 fluconazole 20 µM -0.0568958358341465 0.457226989655265 no 1499 0.477314085732245 2607 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.0582714158488197 0.457724340404483 no 1500 0.476766217831289 2496 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1581 himbacine 57.9 µM -0.059510253306113 0.458172307593916 no 1501 0.476272849497585 2504 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3199 9111318 49.47 µM -0.0597179432841248 0.458247414103695 no 1502 0.476190140282629 2556 8548020 SGTC_248 streptozotocin 5.23457 mM -0.0599370367998496 0.458326646067661 no 1503 0.476102890902926 2599 5300 DNA alkylating agent. SGTC_1307 1187-1599 12.2 µM -0.0599690172488791 0.458338211467646 no 1504 0.476090155458163 2527 1538471 SGTC_2031 5180455 200 µM -0.0601986254514198 0.458421247944144 no 1505 0.475998720231071 2511 29949 SGTC_207 4185-0010 4.486 µM -0.0606613845846633 0.458588607614236 no 1506 0.475814442826963 2507 3761753 SGTC_1341 1486-1360 280 µM -0.0606865734629541 0.45859771753702 no 1507 0.475804412398088 2514 3976547 SGTC_2477 5967686 25.23 µM -0.0616783304207295 0.458956418044605 no 1508 0.475409498463209 2528 776118 SGTC_1792 st045773 43.6 µM -0.0636818629356692 0.459681161076058 no 1509 0.47461177335518 2526 2919270 SGTC_2304 7443016 91.4 µM -0.06733381248696 0.46100253333091 no 1510 0.473157979743663 2514 939854 SGTC_231 b-estradiol 524 µM -0.0674213022942401 0.461034194805511 no 1511 0.473123155496657 2521 450 A steroid. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0674629819284497 0.461049278234332 no 1512 0.473106565500597 2514 6708561 SGTC_172 1112-0046 2.638 µM -0.0693649297050405 0.461737632755883 no 1513 0.472349571848554 2551 2802135 YIL048W NEO1 SGTC_2283 7944793 200 µM -0.0701778182628459 0.462031869146016 no 1514 0.472026064625357 2560 2970533 SGTC_542 3381-0244 89.3 µM -0.0715121625599832 0.46251489871606 no 1515 0.471495072509381 2566 1112843 SGTC_2240 6690706 185.951 µM -0.0718475103828585 0.462636302578214 no 1516 0.471361631335842 2519 805876 SGTC_272 doxorubicin 8.13 µM -0.0723527597198257 0.462819221385272 no 1517 0.471160589246575 2504 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2850 9015429 58.44 µM -0.0724048828986024 0.462838092337415 no 1518 0.471139849502568 2579 6457570 SGTC_2267 7931562 200 µM -0.07279050349747 0.462977707060053 no 1519 0.470986414010788 2508 934880 SGTC_3207 9114163 49.47 µM -0.0731117671058867 0.463094024686451 no 1520 0.470858588961751 2576 849233 SGTC_2160 5660466 132.927 µM -0.0736208124818301 0.463278337577047 no 1521 0.470656055055738 2517 2859134 SGTC_1932 st074806 40.9 µM -0.0744684429434208 0.463585261325153 no 1522 0.470318825154269 2756 17251235 SGTC_366 0181-0206 4.31 µM -0.0744929661487251 0.463594141407494 no 1523 0.470309068909163 2561 274874 SGTC_2953 9074162 66.49 µM -0.075000567696257 0.463777952749289 no 1524 0.470107130105145 2557 16451992 SGTC_699 0375-0592 111 µM -0.077410354010735 0.464650683076155 no 1525 0.469148552095423 2531 762578 SGTC_2780 5215298 71.43 µM -0.0780473312895717 0.464881399920138 no 1526 0.468895201432278 2561 2834131 SGTC_2291 7917025 104.35 µM -0.0785510225686046 0.46506384816986 no 1527 0.468694872712837 2558 2964612 SGTC_1644 st010134 20.9 µM -0.0795031888994026 0.465408764151081 no 1528 0.468316197634498 2563 3818134 SGTC_1677 st019204 53.9 µM -0.0802044170209427 0.46566279605103 no 1529 0.468037338603572 2675 3945625 SGTC_1468 k284-1086 134 µM -0.0803648172454987 0.465720905750353 no 1530 0.467973554069311 2573 15996457 SGTC_2712 st079126 47.7 µM -0.0813586791016416 0.46608097768802 no 1531 0.467578354714218 2543 3152970 SGTC_1825 st052143 62.6 µM -0.0813633608327144 0.466082673925282 no 1532 0.46757649314539 2603 674173 SGTC_3304 9125678 46.087 µM -0.0815516722803752 0.466150901527263 no 1533 0.467501616574945 2569 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0823520454254611 0.466440897842973 no 1534 0.467183384332946 2556 688664 SGTC_2321 7390090 138.78 µM -0.082540499597728 0.466509182360963 no 1535 0.467108457083845 2620 649046 SGTC_1922 5578187 25 µM -0.0826639990676602 0.466553931715492 no 1536 0.467059355722304 2667 1350412 SGTC_446 go6976 132 µM -0.0859318253660749 0.467738162494568 no 1537 0.465760306045455 2583 3501 A protein kinase C inhibitor. SGTC_666 0272-0154 136 µM -0.0875269137424567 0.468316312507105 no 1538 0.46512634672321 2587 6870312 SGTC_60 0986-0278 202 µM -0.0898879114083284 0.469172193567209 no 1539 0.464188143780626 2558 3110598 SGTC_2834 9001755 58.44 µM -0.090326993253446 0.469331380175628 no 1540 0.4640136851546 2706 2989575 SGTC_2189 6047310 154.431 µM -0.0903298929738657 0.469332431468983 no 1541 0.464012533043293 2542 711535 SGTC_2808 7946468 45.46 µM -0.0917189781612713 0.469836068617677 no 1542 0.463460659278019 2634 2970879 SGTC_2184 6075246 200 µM -0.0921593316303163 0.469995736588566 no 1543 0.463285724571651 2611 2267320 SGTC_885 0865-0106 16.8 µM -0.0931098793604382 0.47034041254932 no 1544 0.4629081344697 2572 2793380 SGTC_2328 6201408 200 µM -0.0933850688725673 0.47044020255487 no 1545 0.462798825996642 2632 2890418 SGTC_2642 cholecalciferol 100 µM -0.0938206235417135 0.470598148422617 no 1546 0.462625824363796 2590 9821465 A vitamin D precursor, similar to steriods. SGTC_183 3914-0051 30.55 µM -0.0948855765053393 0.470984353404567 no 1547 0.462202856553408 2624 1596232 SGTC_1835 st008666 49.2 µM -0.0959581391806744 0.471373345629879 no 1548 0.461776909589156 2589 690455 SGTC_2176 5809774 33.9695 µM -0.0965997793891682 0.471606065906143 no 1549 0.461522115849314 2650 2870539 SGTC_2804 7954240 19.48 µM -0.0967550782236706 0.471662393617788 no 1550 0.461460449435968 2671 828705 SGTC_260 nsc-65238 3.989 µM -0.0975474746681798 0.471949808815268 no 1551 0.461145817315927 2581 3246252 SGTC_3284 9108171 64.8615 µM -0.0976283339964004 0.471979138644803 no 1552 0.461113712349894 2663 8687505 SGTC_970 1315-0089 19.5 µM -0.0981576522478883 0.472171140202566 no 1553 0.46090355431459 2576 6811083 YLR033W RSC58 SGTC_2939 9044578 71.43 µM -0.0986945804984677 0.472365908770341 no 1554 0.460690385996652 2595 2653634 SGTC_1911 st060208 74.3 µM -0.0993900104728515 0.472618183017369 no 1555 0.460414306989889 2674 688783 SGTC_610 4215-0184 155 µM -0.0995067453760261 0.472660530861924 no 1556 0.460367966223582 2627 5605015 SGTC_1603 st002045 67.8 µM -0.0999916877070388 0.472836456377543 no 1557 0.460175462310209 2596 5887985 SGTC_2305 7443522 69.23 µM -0.100555194775312 0.473040889960438 no 1558 0.459951782871631 2607 5415886 SGTC_2534 helenine 20.12 µM -0.101359388506 0.473332654053196 no 1559 0.459632586834187 2596 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_760 0568-0725 82.9 µM -0.102476785853554 0.473738073149615 no 1560 0.459189119018447 2703 3916171 SGTC_1821 st053465 65.6 µM -0.105402018122079 0.47479954673595 no 1561 0.458028407378141 2671 675086 SGTC_2204 7233102 200 µM -0.105974408623605 0.475007270176311 no 1562 0.457801328393369 2592 2172480 SGTC_2607 solasodine 47.35 µM -0.109091369591489 0.476138549017043 no 1563 0.456565010051624 2631 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3089 9117425 49.47 µM -0.110176879666019 0.476532572813333 no 1564 0.456134548991146 2665 9401657 SGTC_1108 betulinic acid 729.144 nM -0.11023236807662 0.476552714889793 no 1565 0.456112546336363 2613 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2023 5144124 124 µM -0.110332255878959 0.476588973923104 no 1566 0.456072938461775 2624 2830192 SGTC_1256 0570-0116 285 µM -0.110829807934668 0.476769587010658 no 1567 0.455875653821577 2631 410638 SGTC_1959 st077091 55.8 µM -0.111796444014488 0.477120492802399 no 1568 0.455492403557201 2585 821356 YKL052C ASK1 SGTC_3198 9112019 49.47 µM -0.112129982511872 0.477241577237196 no 1569 0.455360172361279 2614 45595555 SGTC_2417 cerulenin 830 nM -0.11267307394828 0.477438740137506 no 1570 0.455144874579838 2589 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1946 st076057 65.1 µM -0.112847539222765 0.477502078859065 no 1571 0.455075714089968 2604 953009 SGTC_1989 st071868 50.2 µM -0.113220393105817 0.477637443448783 no 1572 0.454927914131018 2661 16414057 SGTC_2639 lactacystin 53 µM -0.113822581264824 0.477856073281455 no 1573 0.454689218831578 2684 3870 A proteasome inhibitor. SGTC_2544 sphondin 68.51 µM -0.114360970932726 0.47805154614221 no 1574 0.454475825823068 2822 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1686 st019653 115.5 µM -0.11442765640321 0.478075757970255 no 1575 0.454449395669672 2599 97252 SGTC_212 3807-4682 38.772 µM -0.115402251034898 0.478429618115229 no 1576 0.454063147408407 2687 3125501 YBL034C STU1 SGTC_2145 5634607 200 µM -0.11603153463166 0.47865811024892 no 1577 0.453813774780557 2591 308662 SGTC_1613 st002381 52.1 µM -0.116925688473312 0.478982788503422 no 1578 0.453459470659549 2625 551167 SGTC_2074 5212007 75.395 µM -0.116985248158071 0.479004415855136 no 1579 0.453435871736184 2606 758611 SGTC_202 3594-0513 34.79 µM -0.119510080326852 0.479921290614029 no 1580 0.452435627163728 2584 708429 SGTC_1281 0884-0031 11.8 µM -0.119860992331138 0.480048730320267 no 1581 0.452296632625376 2621 1548255 SGTC_2745 rifampicin 24.3 µM -0.120051938635848 0.480118076599742 no 1582 0.452221002177647 2705 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2009 4012297 12.05 µM -0.120366992394029 0.480232496499084 no 1583 0.452096218758204 2714 45595307 SGTC_2511 berberine 10.47 µM -0.12101181061315 0.480466683936839 no 1584 0.451840840214336 2656 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1408 3909-7976 48.8 µM -0.122397752765471 0.480970058187574 no 1585 0.451292009082044 2648 24152374 SGTC_3082 9117008 49.47 µM -0.122492084822622 0.48100432070691 no 1586 0.45125465709287 2672 41448529 SGTC_545 4218-0007 221 µM -0.122753384161757 0.481099228450606 no 1587 0.451151194519241 2704 2840508 SGTC_2810 7959871 45.46 µM -0.123542549977057 0.481385871504731 no 1588 0.450838741166153 2724 2974535 SGTC_2485 5633444 17.78 µM -0.123580273916809 0.481399573943719 no 1589 0.450823805939088 2705 5724239 SGTC_2996 9066192 71.4286 µM -0.124005317928567 0.481553963883432 no 1590 0.450655532233797 2655 6472854 SGTC_3249 9135183 49.47 µM -0.124979157611962 0.481907704821943 no 1591 0.450270025383305 2791 4902779 SGTC_413 propylparaben 100 µM -0.125090383438228 0.481948107792377 no 1592 0.450225998200913 2624 7175 A pharmaceutical preservative. SGTC_3101 9120531 49.47 µM -0.125733641596154 0.482181776035375 no 1593 0.449971385518793 2781 24824904 SGTC_192 3455-0609 60.9 µM -0.125954243053728 0.482261912546155 no 1594 0.449884072390753 2736 3769639 SGTC_3183 9108214 49.47 µM -0.125996143919535 0.482277133692515 no 1595 0.449867488478527 2617 4974831 SGTC_1522 st012842 45.6 µM -0.126986415732026 0.482636872923534 no 1596 0.449475575089833 2614 3491067 YOR116C RPO31 SGTC_2625 euphol 100 µM -0.127200684618864 0.482714712942612 no 1597 0.449390781768102 2721 6708538 A triterpene alcohol. SGTC_591 4299-0174 154 µM -0.127676127472636 0.482887435098471 no 1598 0.449202641483871 2673 5509088 SGTC_2387 9077560 195.08 µM -0.127908009072455 0.482971675810965 no 1599 0.449110886394625 2609 5303272 SGTC_1207 2099-0101 141 µM -0.129705269977187 0.483624631676308 no 1600 0.448399806477472 2722 5837381 SGTC_2363 9053361 176 µM -0.129764299172177 0.483646078097927 no 1601 0.448376454584242 2766 6469797 YMR079W SEC14 SGTC_888 0916-0002 6.97 µM -0.130541034232218 0.483928285002107 no 1602 0.448069195627938 2801 2802138 YIL048W NEO1 SGTC_2790 5423970 71.43 µM -0.130687365654656 0.483981451703605 no 1603 0.448011313683406 2760 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1015 4130-4525 82 µM -0.131254503626189 0.484187513035216 no 1604 0.447786990595154 2655 1363237 SGTC_1334 1486-0610 236 µM -0.131908963360923 0.484425306704248 no 1605 0.44752814942375 2769 3742339 SGTC_813 k007-0158 173 µM -0.131924899320207 0.484431097000369 no 1606 0.447521846972946 2715 6523916 SGTC_47 0149-0135 24.25 µM -0.13284799005182 0.484766505572028 no 1607 0.447156800058887 2592 5239155 SGTC_3314 9135860 59.4275 µM -0.133268513941969 0.484919308134631 no 1608 0.446990513841989 2661 25252478 SGTC_392 N-ethylmaleimide 8.33 µM -0.133287315935324 0.484926140123618 no 1609 0.446983079256261 2674 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2933 9026794 32.47 µM -0.134113082870877 0.485226199380061 no 1610 0.446656577234608 2692 17586027 SGTC_3126 9127922 49.47 µM -0.134192827064676 0.485255176504799 no 1611 0.446625048892434 2890 45595682 SGTC_2722 naftopidil 47.16 µM -0.134385464027253 0.485325176471195 no 1612 0.446548887698073 2637 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1477 0139-0234 16 µM -0.13442003822467 0.485337740009664 no 1613 0.446535218608045 2620 620880 SGTC_2276 7947513 42.08 µM -0.135310171880031 0.485661200893332 no 1614 0.446183321522544 2734 2105100 SGTC_2965 9082772 38.63 µM -0.135416693645751 0.485699909901368 no 1615 0.446141213041343 2719 16459634 SGTC_2431 5490079 200 µM -0.135919206243649 0.4858825200654 no 1616 0.445942575995295 2687 5722345 SGTC_1093 fluphenazine 7.97 µM -0.136243712855578 0.486000445461936 no 1617 0.445814309731099 2661 6602611 An atypical antipsychotic. SGTC_799 1310-0557 151 µM -0.136701600654008 0.486166843535836 no 1618 0.445633332136346 2786 5354492 SGTC_1458 k015-0034 6.33 µM -0.136946420116601 0.486255812799651 no 1619 0.445536573256314 2686 3598957 SGTC_550 4123-0385 25.7 µM -0.138257122422786 0.48673214356142 no 1620 0.445018605674479 2657 5731123 SGTC_904 1141-0088 396 µM -0.139382213072813 0.487141035120261 no 1621 0.444574063534223 2696 1378119 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.140188408534317 0.48743403897807 no 1622 0.444255565056697 2616 5711223 A potent inhibitor of glutathione S-transferases. SGTC_869 0564-0080 44.1 µM -0.140200303322069 0.487438362073542 no 1623 0.444250866128036 2703 6843321 SGTC_1950 st077106 7.18 µM -0.140727893651641 0.487630113366993 no 1624 0.444042454216459 2743 13831864 SGTC_2407 paclitaxel 400 µM -0.141447342933076 0.487891599882976 no 1625 0.443758277973331 2928 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2750 bromebric acid 70.15 µM -0.141948731165178 0.488073834384434 no 1626 0.443560251048578 2771 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1429 4049-0205 9.46 µM -0.142368673949298 0.488226468651744 no 1627 0.443394402438469 2638 22774478 SGTC_770 0389-1121 67.2 µM -0.142978659394329 0.488448179733268 no 1628 0.443153517674747 2842 6753108 SGTC_2735 sertaconazole 140 nM -0.143140244128623 0.488506911450601 no 1629 0.443089710978737 2650 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.143931363744062 0.48879446578699 no 1630 0.442777334427648 3001 5282309 SGTC_1658 st012944 20 µM -0.145281864334213 0.489285356009805 no 1631 0.442244166483791 2721 24207260 SGTC_1200 1643-0193 18.4 µM -0.146669545317659 0.489789777745167 no 1632 0.441696428954696 2643 5403974 SGTC_2451 5856223 45.7 µM -0.147219454246165 0.489989674083892 no 1633 0.441479402818098 2700 2179896 SGTC_2444 5485484 36.41 µM -0.147675866447179 0.490155585518337 no 1634 0.441299289282959 2775 6790631 SGTC_386 1509-0011 3.07 µM -0.148346545498959 0.490399388664093 no 1635 0.441034641849823 2669 3107280 SGTC_1900 st060200 72.8 µM -0.148458139897274 0.490439955460355 no 1636 0.440990609671463 2648 688945 SGTC_2452 5863136 48.41 µM -0.149261362311758 0.490731945768582 no 1637 0.440673701046567 2644 2184096 SGTC_3120 9124077 49.47 µM -0.149965565129483 0.49098794420728 no 1638 0.440395891509518 2641 18774327 YGL155W CDC43 SGTC_1240 0356-0016 42.1 µM -0.150668739652813 0.491243572534851 no 1639 0.440118516909396 2748 4305613 SGTC_531 3788-1495 174 µM -0.150761363577595 0.491277244814333 no 1640 0.440081982613672 2635 2896655 SGTC_3349 9149703 23.001 µM -0.151206913432077 0.491439219804322 no 1641 0.439906248435656 2650 4910494 SGTC_1936 st074407 74.3 µM -0.151638713487815 0.491596197546011 no 1642 0.439735948761868 2665 809813 SGTC_2435 5706476 10.6 µM -0.151838984817174 0.4916690051615 no 1643 0.439656966584829 2770 5725375 SGTC_495 decylubiquinone 155 µM -0.152306764700242 0.491839065217912 no 1644 0.439472494854568 2729 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_269 exalamide 29 µM -0.15236608849371 0.491860632322247 no 1645 0.439449101108194 2710 3316 A derivative of salicylamide. SGTC_924 2046-0044 21.3 µM -0.152396075429592 0.491871534051122 no 1646 0.439437276139512 2662 3623589 SGTC_1123 mangostin 811.285 nM -0.152660506702885 0.491967668111392 no 1647 0.439333003353738 2768 5281650 An antioxidant. SGTC_3058 9093861 49.47 µM -0.15543084901694 0.492974853789799 no 1648 0.438240832842656 2829 17217477 SGTC_474 dl-dihydrosphingosine 5 µM -0.156600032844812 0.493399936084509 no 1649 0.437780038328775 2843 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1896 st058441 89 µM -0.156802653029297 0.49347360384968 no 1650 0.437700190951872 2719 688759 SGTC_1257 0669-0121 16 µM -0.157261870000196 0.493640564778071 no 1651 0.437519234809512 2799 4307855 SGTC_35 0133-0054 64.071 µM -0.158634941370882 0.49413978907486 no 1652 0.436978249065808 2712 99677 SGTC_3231 9132313 49.47 µM -0.158862522532551 0.49422253443985 no 1653 0.436888594169525 2737 4905967 SGTC_1875 nocodazole 6 µM -0.159042261684936 0.494287885287353 no 1654 0.436817788775794 2686 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2467 5474540 200 µM -0.159981412076011 0.494629350761455 no 1655 0.43644785831462 2680 5413519 SGTC_294 k038-0071 157 µM -0.160280658613066 0.494738154579484 no 1656 0.43632999704387 2736 24152826 SGTC_1090 efavirenz 20.7 µM -0.161219267121182 0.495079428162889 no 1657 0.43596035332352 2734 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1434 4073-0095 163 µM -0.163041921836175 0.49574214679924 no 1658 0.435242713704918 2705 24133745 SGTC_2394 5221648 200 µM -0.163615822918255 0.495950820186805 no 1659 0.435016793842852 2817 788586 SGTC_1333 1482-0047 286 µM -0.164188406742259 0.496159015716717 no 1660 0.43479141366761 2696 3811116 SGTC_1446 4239-0190 62 µM -0.164748068371184 0.496362513656477 no 1661 0.434571140395704 2707 1340085 SGTC_2831 7999036 19.48 µM -0.165052829827373 0.496473328030575 no 1662 0.434451200020774 2991 2988270 SGTC_651 3253-0966 34.4 µM -0.166212340334577 0.496894940292351 no 1663 0.433994924173803 2727 781462 SGTC_165 k038-0023 64.381 µM -0.167534785979591 0.497375801977923 no 1664 0.433474639523816 2726 46368543 SGTC_1853 st056710 91.2 µM -0.168269877119315 0.497643094176482 no 1665 0.433185485257379 2887 269167 SGTC_2083 5306046 65.942 µM -0.168413395964566 0.497695280305681 no 1666 0.433129035083827 2741 539837 SGTC_2425 5628681 7.85 µM -0.169389713329585 0.498050288511758 no 1667 0.432745057082297 2797 5714958 SGTC_2701 st077767 14.721 µM -0.16946767546014 0.498078637146866 no 1668 0.432714397917619 2730 5721188 SGTC_2482 5981709 142.65 µM -0.169728484274883 0.498173472668981 no 1669 0.43261183593359 2786 877755 SGTC_2809 7964133 12.99 µM -0.170049407093019 0.498290167037006 no 1670 0.432485640598126 2765 1253665 SGTC_456 gingerol 170 µM -0.171824664079534 0.498935690636986 no 1671 0.431787687380669 2875 442793 A herb. SGTC_1726 st035556 14.5795 µM -0.172210565739271 0.499076013637345 no 1672 0.43163599585834 2937 5919439 SGTC_2727 riluzole 51.77 µM -0.174375240481123 0.49986314236267 no 1673 0.430785285720709 2710 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_530 4358-1714 28 µM -0.174751610898227 0.5 no 1674 0.430637406024968 2823 1564641 SGTC_3270 9137563 49.47 µM -0.175283072176273 0.499806747475034 no 1675 0.430428606149102 2836 17015724 SGTC_1308 1187-1617 41.4 µM -0.175361814896748 0.499778114668251 no 1676 0.430397671455574 2685 2882570 SGTC_2497 7-hydroxyflavone 100 µM -0.175921572687808 0.499574572889351 no 1677 0.430177778551966 2895 5281894 SGTC_2311 7694451 200 µM -0.176387479914347 0.499405157579372 no 1678 0.429994770019163 2795 2163142 SGTC_992 3909-8734 162 µM -0.177575344909986 0.498973221250494 no 1679 0.429528244345647 2771 4288319 SGTC_3115 9123671 49.47 µM -0.177842948372099 0.498875914332999 no 1680 0.429423158514123 2691 3286988 SGTC_479 n-linoleoylglycine 10 µM -0.179746400338764 0.498183776665707 no 1681 0.428675832221242 2728 6433346 An anti-infammatory. SGTC_339 3091-4833 71.4 µM -0.179760461393228 0.498178663769889 no 1682 0.428670312569877 2730 3240077 SGTC_1384 3089-0840 101 µM -0.179809860993418 0.498160701036267 no 1683 0.428650920922118 2802 1069836 SGTC_1605 st000082 49.1 µM -0.181117497738408 0.497685218281208 no 1684 0.428137675260226 2848 1114022 SGTC_2970 9090938 41.86 µM -0.18180654479865 0.497434668331455 no 1685 0.427867274059151 2955 17217104 SGTC_103 0844-0104 51.839 µM -0.182470037356131 0.49719341141533 no 1686 0.427606933164066 2850 5375804 SGTC_1073 triclabendazole 3.09 µM -0.182743666193961 0.497093915718162 no 1687 0.427499575983193 2796 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1826 st055655 41.6 µM -0.185080487873851 0.496244219042439 no 1688 0.426582952813567 2789 676168 SGTC_2849 9019321 12.99 µM -0.185763385640032 0.495995912186085 no 1689 0.426315159365926 2858 16489627 SGTC_1957 st077035 62.4 µM -0.185899281702758 0.495946499519199 no 1690 0.426261872750994 2750 705593 SGTC_2165 5727197 32.143 µM -0.186294366848257 0.49580284442043 no 1691 0.426106962372503 3146 1361712 SGTC_1319 1306-0155 43.7 µM -0.186652611871594 0.495672585059614 no 1692 0.425966506627701 2738 3122360 SGTC_1325 1431-0015 227 µM -0.186661820990923 0.495669236592052 no 1693 0.425962896167539 2727 1103340 SGTC_3334 9142812 21.919 µM -0.187877498406908 0.49522721485835 no 1694 0.42548634114482 2859 45283678 SGTC_2181 6316240 54.2555 µM -0.188484334861277 0.495006570570752 no 1695 0.425248497204564 2816 12779990 SGTC_2028 5153890 36.43 µM -0.188804496666514 0.494890161113197 no 1696 0.42512302370038 2744 2830968 YPR165W RHO1 SGTC_1591 genipin 88.4 µM -0.189015862663675 0.494813309582107 no 1697 0.425040192140102 2893 442424 A DNA cross-linking agent. SGTC_981 1488-1094 54.9 µM -0.189791538631897 0.494531279674962 no 1698 0.424736243290924 2710 3449522 SGTC_2478 5763493 32.33 µM -0.191934548160807 0.493752112279485 no 1699 0.423896737500688 2728 1365576 YLR208W SEC13 SGTC_1995 st072814 61.1 µM -0.192056873870788 0.493707637104333 no 1700 0.423848827822642 2757 5769371 SGTC_2296 7971656 126.45 µM -0.192902738316951 0.493400099924061 no 1701 0.423517570223496 2820 666570 SGTC_2161 5662504 8.5105 µM -0.193385987539452 0.493224403186217 no 1702 0.42332834431314 2773 2859334 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.19413074458381 0.492953631651623 no 1703 0.423036754419108 2962 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2325 6158266 200 µM -0.194450385628125 0.492837420652904 no 1704 0.422911620354365 2828 3623240 SGTC_290 2043-6722 48.1 µM -0.194723099450932 0.4927382713328 no 1705 0.422804863651452 2825 773758 YLR208W SEC13 SGTC_595 3909-8003 73.7 µM -0.195286413579752 0.492533471212834 no 1706 0.422584366350471 2851 699517 SGTC_2114 5491910 81.25 µM -0.195456995145392 0.492471454469393 no 1707 0.422517600616303 2869 2849228 SGTC_1570 verbenone 133 µM -0.196839400288875 0.491968873212499 no 1708 0.421976608637983 2914 29025 A natural terpanoid with antifungal properties. SGTC_1316 1272-0050 65.9 µM -0.197054695038636 0.491890602708195 no 1709 0.421892368170812 2748 7340392 SGTC_899 1083-0020 478 µM -0.197082337222392 0.491880553402259 no 1710 0.42188155260398 2929 767123 SGTC_100 0086-0128 49.5915 µM -0.198107617272136 0.491507816904611 no 1711 0.421480432613488 2795 93297 SGTC_781 4335-2806 94.4 µM -0.198141293329258 0.491495574231544 no 1712 0.421467258919908 2931 845254 SGTC_1286 0929-0070 131 µM -0.198890465090195 0.491223220658962 no 1713 0.421174214135615 2871 1420408 SGTC_425 3825-7017 13.1 µM -0.199266541433196 0.491086503565208 no 1714 0.42102712518668 3015 3397440 SGTC_1511 0906-3109 28.5 µM -0.199588249411723 0.490969552131328 no 1715 0.420901309245496 2732 2882180 SGTC_517 1365-0151 113 µM -0.200455207687016 0.490654388169973 no 1716 0.420562293029503 2932 768657 SGTC_3133 9127736 49.47 µM -0.200812889922413 0.490524362205422 no 1717 0.420422441769046 2744 27243420 SGTC_1168 k815-0004 80.5 µM -0.201741665077939 0.490186735174023 no 1718 0.420059344106062 2749 642433 SGTC_1561 5-methoxyflavone 52.9 µM -0.202017573055558 0.4900864388398 no 1719 0.419951493049523 2759 94525 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.202083982136001 0.490062298321547 no 1720 0.41992553496745 2892 688662 SGTC_1885 st057546 99.9 µM -0.20234852092291 0.489966135578167 no 1721 0.419822135104077 2918 702008 SGTC_2693 st077581 40.7 µM -0.203017523674354 0.489722948373642 no 1722 0.419560667754357 2847 25238761 SGTC_568 1193-0097 7.48 µM -0.203604358896878 0.489509632786054 no 1723 0.419331343295233 2829 3646150 SGTC_251 melphalan 456.522 µM -0.204526905118789 0.489174291777118 no 1724 0.418970884546794 2834 460612 A DNA alkylator. SGTC_578 3460-0051 92 µM -0.205125402522669 0.488956744995751 no 1725 0.418737075027645 2768 2876744 SGTC_2024 5144227 134 µM -0.205541781009878 0.488805398237036 no 1726 0.418574429169207 2926 3475211 SGTC_1829 berberine 14.4 µM -0.206665866015315 0.488396819864803 no 1727 0.41813540841917 2926 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_360 0957-0399 1.01 µM -0.20683771709806 0.488334357114186 no 1728 0.41806829952288 2927 6752301 YPR165W RHO1 SGTC_1553 gossypol 38.6 µM -0.206870268939509 0.488322525521445 no 1729 0.418055588098843 2730 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2072 5231554 129 µM -0.20869876873602 0.487657938917884 no 1730 0.417341700691814 2876 789545 SGTC_1808 st050063 61.5 µM -0.209609484110861 0.487326942944414 no 1731 0.416986238416511 2900 4011993 SGTC_497 capsazepine 133 µM -0.210868167717414 0.486869493683176 no 1732 0.416495072041924 2787 2733484 A calcium channel blocker. SGTC_1495 4469-0029 237 µM -0.211496956418515 0.486640976502417 no 1733 0.416249753463548 2758 793680 SGTC_449 xestospongin c 11.1929 µM -0.211617357029554 0.486597220475994 no 1734 0.416202783521846 2903 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_975 1335-0046 28.5 µM -0.211652364062842 0.486584498239639 no 1735 0.41618912701907 2822 16486740 SGTC_2250 alverine citrate 130 µM -0.212056559064535 0.486437606911578 no 1736 0.416031454890263 2718 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_768 0384-0033 77.3 µM -0.212703996734297 0.486202320909591 no 1737 0.415778924579302 2792 3965305 YMR134W ERG29 SGTC_271 rotenone 740 µM -0.213152254948642 0.486039421731187 no 1738 0.415604103734929 2914 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3073 9114972 49.47 µM -0.213280690161777 0.485992748188791 no 1739 0.415554017038458 2891 41905075 SGTC_410 α-linolenic acid 100 µM -0.214795984270029 0.485442102776008 no 1740 0.414963191958518 2909 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1358 1509-0022 2.48 µM -0.215242320557366 0.485279913086391 no 1741 0.41478919853262 2841 3258434 SGTC_3325 9138760 55.175 µM -0.21535008990795 0.485240752221431 no 1742 0.414747189757033 2826 43844959 SGTC_2520 obtusaquinone 4.71 µM -0.215505002199907 0.485184460962101 no 1743 0.414686806247272 2950 5967872 SGTC_2027 5150920 200 µM -0.217321297025027 0.484524487091295 no 1744 0.413978980527602 2869 786715 SGTC_2569 tetrandrine 100 µM -0.218859055474735 0.483965756029068 no 1745 0.413379921106686 2859 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_536 3852-0578 10.6 µM -0.220418541689452 0.483399162532535 no 1746 0.412772603152822 2957 2869208 SGTC_883 0850-0245 24.6 µM -0.222193331816457 0.482754385532844 no 1747 0.4120816924132 2999 6823229 YPR165W RHO1 SGTC_2983 9022671 12.99 µM -0.222276726254554 0.482724089629593 no 1748 0.412049234350419 2997 6405161 SGTC_145 3737-0113 38.366 µM -0.222408345432391 0.482676274630928 no 1749 0.411998007895256 2933 6849351 SGTC_1057 3448-5381 134 µM -0.222856090639909 0.482513618316195 no 1750 0.411823755770374 2933 5497911 SGTC_2716 st080858 38.6235 µM -0.223039348587068 0.482447045437968 no 1751 0.411752441009541 2938 5296050 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.22331913180446 0.482345408367154 no 1752 0.411643569099195 2928 5024745 SGTC_2246 7293507 91.5585 µM -0.223882750794321 0.482140665541194 no 1753 0.411424268971641 2979 887656 SGTC_1743 st037606 46.3785 µM -0.224080796493376 0.482068723665416 no 1754 0.411347217369494 2812 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_682 0kpi-0099 17 µM -0.224266558274475 0.482001244563619 no 1755 0.411274948052631 2894 1714895 YML126C ERG13 SGTC_3182 9108849 49.47 µM -0.224649783944381 0.481862037129228 no 1756 0.411125866310888 2893 17133045 SGTC_827 3253-0474 693 µM -0.225686310787765 0.481485527961789 no 1757 0.410722702914783 2922 5402065 SGTC_2334 9017922 200 µM -0.226428779830386 0.481215842809614 no 1758 0.410433973024759 2960 3163164 SGTC_2203 7227154 166.4 µM -0.228223608435093 0.480563947503914 no 1759 0.409736204409001 2799 896304 SGTC_972 1319-0219 195 µM -0.228424969910769 0.48049081470556 no 1760 0.409657939671212 2897 23903702 SGTC_1700 st030840 7.9285 µM -0.229160213762584 0.480223785902602 no 1761 0.409372197291177 2919 5499307 SGTC_2333 9017922 200 µM -0.229567067675958 0.480076026877383 no 1762 0.409214099810952 2957 3163164 SGTC_296 1222-0039 74.9 µM -0.229600986374809 0.480063708589348 no 1763 0.409200920167127 2849 5984176 SGTC_1503 4585-0012 61.3 µM -0.230265017621293 0.479822555542078 no 1764 0.408942921075776 3006 2922052 SGTC_2351 9026858 72.31 µM -0.230936118274601 0.479578842636016 no 1765 0.40868221535393 2793 1409300 SGTC_288 1315-0019 35.1 µM -0.232579810062967 0.478981961773394 no 1766 0.408043853325768 2892 6811474 SGTC_1733 st037357 54.9 µM -0.233154251524575 0.478773373422805 no 1767 0.40782081444168 2774 1272339 YGL099W LSG1 SGTC_661 1304-0007 33.6 µM -0.23491052792902 0.478135679297424 no 1768 0.407139089044642 2834 3117130 SGTC_925 2064-1272 59.6 µM -0.235061252784217 0.47808095453151 no 1769 0.407080595973499 2850 6815817 SGTC_502 l-744,832 89.3 µM -0.235537630243575 0.477907995435793 no 1770 0.40689573776954 2952 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1916 st067606 49.2 µM -0.236051301851732 0.477721500559341 no 1771 0.40669643081769 2926 19590279 SGTC_278 4092-0821 23.9 µM -0.237267510558261 0.47727996036127 no 1772 0.406224632664393 2903 877900 SGTC_2131 toluylene red 5.2905 µM -0.237327974500574 0.477258009867672 no 1773 0.406201180716673 2870 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_321 4534-3890 65.3 µM -0.238853676193296 0.476704150618317 no 1774 0.405609523486366 2947 699746 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.240918254254634 0.475954740662967 no 1775 0.404809236963504 2924 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_450 aminopyrene 156 nM -0.243295412936832 0.475091974268781 no 1776 0.403888278801813 2936 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.243996783186863 0.474837440955711 no 1777 0.403616655643405 2933 5379071 SGTC_2585 alliin 100 µM -0.244010439990974 0.474832484885304 no 1778 0.403611367165612 3040 87310 A garlic compound which reacts with lipids. SGTC_1024 4507-0395 26 µM -0.244340003870749 0.474712886945255 no 1779 0.403483751785556 3010 4201836 SGTC_755 1995-0008 37.3 µM -0.245587365739656 0.474260243044422 no 1780 0.403000835219528 2886 689533 SGTC_1972 st070201 17.4 µM -0.246031503257185 0.474099081976736 no 1781 0.402828922903091 2970 2829099 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.246089233886218 0.474078133978781 no 1782 0.402806578486356 3028 688751 SGTC_2097 5376186 200 µM -0.246555157240771 0.473909072773286 no 1783 0.402626256278977 2972 742755 SGTC_209 4077-0173 175.592 µM -0.246591118984509 0.473896024178791 no 1784 0.402612339183011 2922 15993494 SGTC_2000 st075254 36.4 µM -0.24752327314914 0.473557805071902 no 1785 0.402251641192275 2849 17234175 SGTC_2683 piperine 63.03 µM -0.247656856285925 0.473509337853977 no 1786 0.402199957873381 2865 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1134 3477-0009 42.5 µM -0.247761851877899 0.473471243169295 no 1787 0.402159336276324 3115 3973534 SGTC_2761 levamisole 97.89 µM -0.249429226676534 0.472866316071488 no 1788 0.401514389898144 2999 26879 An alkaline phosphatase inhibitor. SGTC_1633 st005664 67.9 µM -0.249745261679642 0.472751664916775 no 1789 0.401392176639128 2816 2063822 SGTC_9 0092-0002 10.449 µM -0.250032336949952 0.472647521728151 no 1790 0.401281170700079 2897 759368 SGTC_395 anisomycin 6.25 µM -0.250562308911157 0.472455267068969 no 1791 0.401076262682716 2902 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2861 9024595 19.48 µM -0.250736039604016 0.472392245251611 no 1792 0.401009097478476 2890 16482810 SGTC_1271 0832-2808 169 µM -0.251189057392732 0.472227913673797 no 1793 0.400833972172506 2995 3663794 SGTC_1342 1486-1464 234 µM -0.252482300789389 0.471758817521531 no 1794 0.400334146491443 2845 3253938 SGTC_1438 4092-1045 4 µM -0.252584983909198 0.471721573104445 no 1795 0.400294467471405 2853 1351342 SGTC_127 0180-0333 59.125 µM -0.252993372758778 0.471573447949881 no 1796 0.400136667210915 2837 771601 SGTC_2982 9019404 25.97 µM -0.253416847212365 0.471419855306603 no 1797 0.399973055134837 2877 22333232 SGTC_2121 5257820 149.641 µM -0.254414352526079 0.471058080598796 no 1798 0.399587731982917 3008 791256 SGTC_416 estradiol valerate 100 µM -0.255126166678807 0.470799934797088 no 1799 0.399312827319148 2904 13791 A steroid. SGTC_2777 climbazole 1.536 µM -0.258677996236999 0.469512017381121 no 1800 0.397941849152467 2933 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2386 9075165 157.42 µM -0.258989816209002 0.469398964383738 no 1801 0.397821548989701 2845 16452277 SGTC_1505 k297-0037 20.6 µM -0.259449560767734 0.469232284565239 no 1802 0.397644197237112 2884 4089396 SGTC_492 tmb-8 126 µM -0.259741044844673 0.469126610166532 no 1803 0.397531764856174 2933 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_766 1391-0721 126 µM -0.261042161650197 0.468654930970411 no 1804 0.397029996905412 3032 1020919 YIL115C NUP159 SGTC_2922 7999257 32.47 µM -0.262958511078375 0.467960298737913 no 1805 0.396291278683445 2838 2988377 SGTC_930 2810-3379 265 µM -0.263660303773615 0.467705939448592 no 1806 0.396020843194902 3067 1015764 SGTC_584 0986-0246 15.4 µM -0.26487304498888 0.467266421990552 no 1807 0.395553631942658 2868 53315 YDR232W HEM1 SGTC_2879 9041815 71.43 µM -0.264893107340282 0.467259151396929 no 1808 0.395545904137077 2989 4942971 SGTC_1289 0976-0073 69.1 µM -0.265448191837526 0.467057993185697 no 1809 0.395332107756892 2978 3391136 SGTC_152 4469-0003 551.229 µM -0.266335148500982 0.466736584621702 no 1810 0.39499055287655 2867 697280 SGTC_1081 sertraline 6 µM -0.267050009217797 0.466477554644409 no 1811 0.394715328493518 2990 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2610 ononetin 44.17 µM -0.268020445932452 0.466125939375019 no 1812 0.394341790369075 2935 259632 SGTC_168 3970-0862 530.542 µM -0.268647398898198 0.465898791528238 no 1813 0.394100516800819 2968 3135186 SGTC_2667 digitoxin 100 µM -0.268769875922162 0.46585441885268 no 1814 0.394053388072733 2966 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_795 0685-0265 78 µM -0.269542585469929 0.465574480726288 no 1815 0.393756087951825 2877 302754 SGTC_2700 st077718 96.8 µM -0.269922901522825 0.465436705624672 no 1816 0.393609784016023 2932 904970 SGTC_372 0155-0182 15.9 µM -0.271134702373484 0.4649977405971 no 1817 0.393143716115757 2872 771486 SGTC_1054 3429-0080 167 µM -0.271167028420504 0.464986031329695 no 1818 0.39313128536397 3066 1162877 SGTC_1828 st055811 49 µM -0.271906497171648 0.464718186360943 no 1819 0.392846957687502 3035 5877589 SGTC_2819 7996655 46.38 µM -0.271908817250415 0.464717346024055 no 1820 0.392846065701004 2958 6456960 SGTC_1478 0453-0656 35.7 µM -0.271955585590088 0.464700406477135 no 1821 0.392828085083419 2933 5258496 SGTC_1264 0783-0040 158 µM -0.271980866812134 0.464691249615801 no 1822 0.392818365526652 2834 2855798 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.2720065217352 0.464681957419032 no 1823 0.392808502366027 2979 140250 A respiratory chain inhibitor. SGTC_1524 corynanthine 62.1 µM -0.274358393168617 0.463830193552409 no 1824 0.391904607033708 3066 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.274383233322202 0.463821198213378 no 1825 0.39189506331477 3100 6728940 SGTC_1145 3546-0597 10.2 µM -0.274502139846072 0.463778138973572 no 1826 0.391849379697797 2944 875334 SGTC_2859 9028643 45.46 µM -0.274906973255901 0.463631541128 no 1827 0.391693854803225 2969 17151580 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.277929469950302 0.462537195236354 no 1828 0.390533250514005 3012 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2851 9015922 71.43 µM -0.278839217411245 0.462207860958681 no 1829 0.390184108219718 3085 2996893 SGTC_3010 9080089 71.4286 µM -0.28084546168166 0.461481679852408 no 1830 0.389414466447487 3015 17027233 SGTC_3220 9131269 49.47 µM -0.280993057582165 0.461428261013078 no 1831 0.38935786232669 2864 17722206 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.281784748190805 0.461141739255287 no 1832 0.389054283210698 3032 6708760 SGTC_532 1548-0774 215 µM -0.281927038373737 0.461090244967772 no 1833 0.388999728252116 3103 5932993 SGTC_2620 irigenin 100 µM -0.282050328479568 0.461045627264942 no 1834 0.388952459813187 3083 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2237 6667747 47.222 µM -0.282405909955016 0.460916947922565 no 1835 0.388816141932712 2889 729940 YDL015C TSC13 SGTC_39 0986-0283 58.349 µM -0.284073070988133 0.460313683361885 no 1836 0.388177191721619 3080 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1986 st071812 45 µM -0.284340142164484 0.460217051733659 no 1837 0.388074863043476 2949 11838594 SGTC_396 dithiazanine 1.25 µM -0.284845410069359 0.460034242254978 no 1838 0.38788129023242 2924 10578 An antihelmenthic. SGTC_3128 9127691 49.47 µM -0.284927933450942 0.460004385517161 no 1839 0.387849677406399 3041 41316314 SGTC_1046 2001-0062 216 µM -0.285756326407428 0.459704687692935 no 1840 0.387532380165844 2895 739778 SGTC_1400 3771-8998 51.5 µM -0.286347458158178 0.459490840736928 no 1841 0.387306006384699 2911 670767 SGTC_147 4466-0538 29.23 µM -0.287066201954493 0.459230844827852 no 1842 0.387030815218851 3136 6742687 YHR072W ERG7 SGTC_2398 5228213 48.84 µM -0.288049503337817 0.458875177033189 no 1843 0.386654422772588 3126 80771 YMR134W ERG29 SGTC_3009 9080819 71.4286 µM -0.288993717423283 0.458533678396348 no 1844 0.386293092653132 2986 17027216 SGTC_3344 9148862 3.898 µM -0.28913852117452 0.458481309198659 no 1845 0.386237688129675 3082 4905352 SGTC_1562 morin hydrate 59.1 µM -0.291610012390857 0.457587590539786 no 1846 0.385292409618304 3099 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2967 9089538 49.85 µM -0.292187378181154 0.457378839391331 no 1847 0.385071680763357 3149 728216 SGTC_264 promethazine 12.5 mM -0.292358677285822 0.457316907110275 no 1848 0.385006199707128 2961 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_236 1509-0011 5.31 µM -0.293717345697376 0.456825724602878 no 1849 0.384486949351142 3032 3107280 SGTC_2891 9063876 19.48 µM -0.293742445472883 0.456816651211107 no 1850 0.384477358767532 3028 6472478 SGTC_485 niflumic acid 177 µM -0.293930166952421 0.456748791934755 no 1851 0.384405632936329 3036 4488 A COX2 inhibitor. SGTC_2369 9071472 200 µM -0.294238305354458 0.45663740598379 no 1852 0.384287906012995 3064 17296037 SGTC_447 ml7 120 µM -0.295328810815114 0.456243237205446 no 1853 0.383871354830333 2990 4216 Selective myosin light chain kinase inhibitor. SGTC_3119 9125183 49.47 µM -0.296418381906576 0.455849449160674 no 1854 0.38345529451736 2975 22695334 SGTC_2800 7887935 81.82 µM -0.29665675412552 0.455763303478378 no 1855 0.383364288320902 3109 2961002 SGTC_1221 2958-7315 257 µM -0.297014740966946 0.455633934002106 no 1856 0.383227627518433 3001 4562705 SGTC_1343 1487-0095 224 µM -0.297253813708362 0.455547540385807 no 1857 0.383136370040573 3065 4560101 YGL055W OLE1 SGTC_778 3456-2434 196 µM -0.29859456496305 0.455063072732202 no 1858 0.382624706449236 3072 5539063 SGTC_1689 st020265 53.493 µM -0.300214472649358 0.454477823780069 no 1859 0.382006783187894 3063 5758320 YPR016C TIF6 SGTC_863 0466-0191 129 µM -0.301852619439404 0.453886085795367 no 1860 0.381382208047633 3062 765160 YPR165W RHO1 SGTC_574 1315-0397 40 µM -0.30186211166681 0.453882657271722 no 1861 0.381378589850659 2928 6794277 SGTC_965 1291-5240 308 µM -0.302500395878585 0.453652121545182 no 1862 0.381135315857147 3069 2834598 SGTC_1876 myriocin 605 nM -0.302980384396875 0.453478769398595 no 1863 0.380952405209468 3113 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2899 9053889 58.44 µM -0.303787004197453 0.453187471423491 no 1864 0.380645084137062 3049 6470052 SGTC_3276 9139060 49.47 µM -0.304309357800154 0.452998845113936 no 1865 0.380446108265955 2915 4870619 SGTC_1258 0671-0043 57.1 µM -0.304373850471717 0.452975556998712 no 1866 0.380421543794264 2982 4298767 SGTC_109 0132-0036 33.701 µM -0.304660068433031 0.452872206482102 no 1867 0.380312532684937 2895 67274 A color developer. SGTC_2829 7992743 58.44 µM -0.306857723752047 0.452078761440499 no 1868 0.379475834561877 3112 16462845 SGTC_2781 5567276 71.43 µM -0.308789600542512 0.451381431444826 no 1869 0.378740790193725 3100 2853274 SGTC_1476 4112-3294 3.34 µM -0.309717950003455 0.451046387771816 no 1870 0.378387725707155 3091 704369 SGTC_3293 9120939 62.045 µM -0.310868015280897 0.450631374686878 no 1871 0.377950480333982 3098 934087 SGTC_774 k060-0086 136 µM -0.31253782834579 0.450028901364255 no 1872 0.377315909468448 3132 5911235 SGTC_2213 7173844 200 µM -0.314132923871176 0.449453493858905 no 1873 0.376710042313258 2991 892728 SGTC_2149 5554786 194.827 µM -0.315389942541421 0.449000117473054 no 1874 0.376232801081951 2977 745063 YPR165W RHO1 SGTC_2680 butyl paraben 22.24 µM -0.315734732712886 0.448875771566594 no 1875 0.376101930658304 2980 7184 An antifungal and steroid mimetic. SGTC_2952 9073731 13.78 µM -0.31751352426022 0.448234344208447 no 1876 0.375426989553086 2990 16457353 SGTC_676 falcarinol 140 µM -0.318483626868155 0.447884584779498 no 1877 0.375059056230989 3155 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3027 9089541 49.47 µM -0.31939822046224 0.447554875590379 no 1878 0.374712280041 3062 9943819 SGTC_174 3553-0389 74.3 µM -0.319437077425776 0.447540868532411 no 1879 0.374697549323317 3109 738071 SGTC_696 1560-0013 611 µM -0.319764110000462 0.447422983267676 no 1880 0.374573578161104 3170 1650269 SGTC_3166 9102297 49.47 µM -0.320175476812591 0.447274704680239 no 1881 0.374417656075766 3024 25237072 SGTC_1635 st007035 42.4 µM -0.32028011690112 0.447236987973976 no 1882 0.37437799718004 3037 3716403 SGTC_1882 5615643 20 µM -0.321973631200279 0.446626640502215 no 1883 0.373736335465274 3018 2253075 SGTC_205 1486-1330 71.903 µM -0.323208769362524 0.446181572758186 no 1884 0.373268570020612 2986 4118834 SGTC_391 gliotoxin 8.33 µM -0.323977646766828 0.445904550884483 no 1885 0.372977478798191 3140 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1744 st037937 38.9 µM -0.324293965435064 0.445790590841859 no 1886 0.372857743961699 3171 1016152 SGTC_467 ro 31-8220 72.8 µM -0.325477836487193 0.445364117753426 no 1887 0.372409727090301 3009 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2864 9034755 47.6 µM -0.326325035207778 0.445058964970769 no 1888 0.37208922434204 2991 4930451 SGTC_121 0557-0495 61.343 µM -0.327781695669379 0.444534366168719 no 1889 0.371538364076428 2997 3104427 SGTC_2971 9092186 9.93 µM -0.328214053806926 0.444378676223642 no 1890 0.371374911250247 2927 25236400 SGTC_2979 9012552 45.46 µM -0.329691086488704 0.443846869220287 no 1891 0.370816694739928 3098 17100905 SGTC_1578 josamycin 24.2 µM -0.332849721929034 0.442709940044303 no 1892 0.369623861718541 3004 5282165 A P450 substrate. SGTC_2698 st077697 67.5 µM -0.332907382579351 0.442689189843306 no 1893 0.369602098259513 3037 3154499 SGTC_3217 9129673 49.47 µM -0.333793643722346 0.442370272966832 no 1894 0.369267640093885 3173 17248312 SGTC_1793 st048256 72.231 µM -0.334494970871606 0.442117930170225 no 1895 0.36900304261937 2976 672022 SGTC_233 rapamycin 362 pM -0.334528230832069 0.442105963568164 no 1896 0.368990495805653 3024 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1012 4112-3522 18 µM -0.334964812652233 0.441948890685684 no 1897 0.368825814908209 3154 3112398 SGTC_589 1227-0070 34.1 µM -0.337401459808601 0.441072405009053 no 1898 0.367907142168729 3114 2841384 SGTC_1924 st058459 75.1 µM -0.337685709399552 0.44097017637931 no 1899 0.367800022530767 2947 688683 SGTC_16 erodoxin 22.806 µM -0.337724543431998 0.440956210261908 no 1900 0.367785388699216 3111 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2567 aureobasidin a 60 nM -0.337793881216245 0.440931274078812 no 1901 0.367759260613712 3223 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_744 1594-0068 283 µM -0.337807509337624 0.440926372978722 no 1902 0.367754125293407 3013 668392 SGTC_2244 6635614 200 µM -0.338293637187958 0.440751552072699 no 1903 0.367570959078485 2913 836499 SGTC_54 0159-0055 9 µM -0.339810444688884 0.440206153351759 no 1904 0.366999640882456 3240 3319099 SGTC_721 1187-1332 279 µM -0.340264331291833 0.440042971275121 no 1905 0.366828737883123 2924 25730 SGTC_2364 9055074 200 µM -0.340857121118846 0.439829865817438 no 1906 0.366605573071812 3081 6470630 SGTC_506 n9-isopropylolomoucine 153 µM -0.34156280766689 0.43957619719496 no 1907 0.366339965351526 3140 6610355 SGTC_185 k048-0037 25.491 µM -0.342708401938974 0.43916445062903 no 1908 0.365908920637853 3139 6827589 SGTC_1930 st074634 34.3 µM -0.343113497423492 0.439018867973275 no 1909 0.365756538671594 2986 684253 YOR116C RPO31 SGTC_1406 3909-7906 11.9 µM -0.343371287969599 0.438926227856458 no 1910 0.365659578410735 3048 X1406 SGTC_2841 9004761 38.96 µM -0.344469559932568 0.438531588235076 no 1911 0.365246592253717 3034 2991039 SGTC_347 4534-1311 26.2 µM -0.344667145037215 0.438460596893393 no 1912 0.365172310362878 2975 2862016 SGTC_3289 9119912 71.43 µM -0.346108588491136 0.437942753512036 no 1913 0.364630554593243 3119 17014829 SGTC_868 0527-0199 213 µM -0.346709031726725 0.437727073570224 no 1914 0.364404962148333 3040 2849450 SGTC_746 1095-0025 46.6 µM -0.349141762936633 0.436853423527839 no 1915 0.363491442331519 3192 6749286 SGTC_1310 1188-0297 994 nM -0.34927733265392 0.436804746324477 no 1916 0.363440557043811 3053 1588352 SGTC_2014 4013930 200 µM -0.349635002137449 0.436676327325584 no 1917 0.363306319494671 3099 64556 SGTC_38 0929-0051 58.268 µM -0.351337928725138 0.436064993899445 no 1918 0.362667421664329 3151 1379719 SGTC_808 0711-0032 135 µM -0.351796886915602 0.435900258614467 no 1919 0.362495296699007 3134 4252555 SGTC_2543 pimpinellin 60.67 µM -0.353838950109691 0.435167429749407 no 1920 0.361729790725662 3022 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3261 9137475 49.47 µM -0.353968101988967 0.435121088875394 no 1921 0.361681394265018 3067 17027690 SGTC_968 1309-0633 340 µM -0.355698932803814 0.434500137210113 no 1922 0.36103302216682 3130 3761976 SGTC_1381 2324-0066 62.1 µM -0.356218370037053 0.434313815714808 no 1923 0.360838517888761 3150 10885928 SGTC_2004 4023728 41.89 µM -0.356496887946543 0.434213917690339 no 1924 0.360734241136063 3197 360084 YDR527W RBA50 SGTC_2249 haloperidol 116.36 µM -0.359951260409585 0.432975264181754 no 1925 0.359441791191644 3013 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1009 4106-0057 9.87 µM -0.360168422962609 0.432897416863682 no 1926 0.359360593559522 3198 2928005 SGTC_543 3844-1095 191 µM -0.360251780910004 0.432867535825761 no 1927 0.359329427497032 3105 4230703 SGTC_3088 9117578 49.47 µM -0.360343276939824 0.432834737999212 no 1928 0.359295219826852 3119 678341 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.361343618346173 0.43247618410345 no 1929 0.358921295268758 2986 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_828 2074-0507 139 µM -0.36311166756251 0.431842595678035 no 1930 0.358260734581133 3189 X828 SGTC_1351 1496-0003 46.5 µM -0.364836455566487 0.431224678984365 no 1931 0.357616745206994 3176 3891978 SGTC_1912 st060209 90.8 µM -0.365881627968559 0.430850320858267 no 1932 0.357226703005782 3100 688787 SGTC_688 0527-0193 473 µM -0.366023045752605 0.430799672833959 no 1933 0.357173939518308 3047 4007154 SGTC_408 cantharidin 100 µM -0.368225761300388 0.430010929459689 no 1934 0.356352451505019 3074 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2378 9074213 121.43 µM -0.369107614630843 0.429695235517571 no 1935 0.35602375671655 3064 657714 SGTC_2822 7994718 71.43 µM -0.369395190433454 0.429592296203963 no 1936 0.355916591186228 3074 1018011 SGTC_2015 5119600 184 µM -0.370130103080141 0.429329252011717 no 1937 0.355642776682343 3224 2828786 SGTC_3 0833-0587 95.581 µM -0.370183571623847 0.429310115463838 no 1938 0.355622858222393 3101 5382644 SGTC_839 0122-0028 230 µM -0.372765372085659 0.428386280047225 no 1939 0.354661538670662 3065 759448 SGTC_1627 st003713 25.6 µM -0.372854042418841 0.428354558433227 no 1940 0.354628539141335 3142 16195070 YER133W GLC7 SGTC_2087 5276107 200 µM -0.373395301123777 0.428160934383018 no 1941 0.354427128098699 3035 144405 SGTC_402 epigallocatechin gallate 10 µM -0.374035708027331 0.427931864466019 no 1942 0.354188874993922 3070 65064 An antioxidant. SGTC_221 trifluoperazine 10.304 µM -0.374748679390465 0.42767686722675 no 1943 0.353923692579118 3092 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1212 0520-0165 585 µM -0.375139701992003 0.427537029150069 no 1944 0.353778285790827 3446 5403258 SGTC_1216 1165-0504 9.65 µM -0.375615045140448 0.427367048496074 no 1945 0.353601552046019 3197 6304004 SGTC_718 1130-0073 349 µM -0.376120915534617 0.427186166241105 no 1946 0.35341350285428 3229 6740020 SGTC_2115 tiliquinol 12.7705 µM -0.37622454231626 0.427149114673787 no 1947 0.35337498567673 3122 71208 A bioactive hydroxyquinoline. SGTC_608 k048-0125 159 µM -0.376522503925255 0.427042582624004 no 1948 0.3532642442939 3179 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_999 SEC7.066 22.7 µM -0.378271394865012 0.426417398388822 no 1949 0.352614496520862 3061 740511 YDR170C SEC7 SGTC_3035 9091303 49.47 µM -0.378799556089186 0.426228630392149 no 1950 0.352418358521541 3111 25237002 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.379335428853409 0.42603712351716 no 1951 0.352219396864627 3090 6857784 SGTC_2518 prenyletin 46.28 µM -0.379343960673768 0.426034074609214 no 1952 0.352216229452439 3158 3873459 A coumarin with calcium channel inhibitory activity. SGTC_458 nppb 133 µM -0.380311977481611 0.425688175527942 no 1953 0.351856922788505 3259 4549 A chloride channel blocker. SGTC_2137 5261020 140 µM -0.381693454853994 0.425194634682257 no 1954 0.351344377728472 3059 763655 SGTC_63 0099-0242 26.702 µM -0.382153193151338 0.42503041645043 no 1955 0.351173869056858 3194 3898502 YLR359W ADE13 SGTC_2162 5663267 200 µM -0.382327147164082 0.424968283576695 no 1956 0.351109360449547 3222 6456493 SGTC_2457 5731572 11.68 µM -0.382330855636573 0.424966959005214 no 1957 0.351107985256941 3201 2865357 SGTC_2616 abietic acid 100 µM -0.38296723016423 0.42473967486486 no 1958 0.350872030854265 3239 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_421 streptovitacin 30 mM -0.383160389426561 0.424670692076476 no 1959 0.350800422799359 3236 91467 include heat shock SGTC_3185 9108267 49.47 µM -0.383449513524158 0.424567441767024 no 1960 0.350693248538026 3160 4910486 SGTC_793 0488-0545 106 µM -0.38387325014666 0.424416128771957 no 1961 0.35053619676408 3047 292548 SGTC_2361 9034121 116 µM -0.384396878279133 0.424229160698663 no 1962 0.350342156953961 3102 6496917 SGTC_3313 9133968 57.047 µM -0.385674000970195 0.423773219416234 no 1963 0.349869060071499 3131 1494643 SGTC_3172 9105863 49.47 µM -0.387794087217605 0.423016560094258 no 1964 0.349084210754357 3116 2348785 SGTC_2252 omeprazole 400 µM -0.387885011880786 0.422984115387755 no 1965 0.349050565130631 3072 4594 A proton pump inhibitor. SGTC_621 3584-0052 32.1 µM -0.3883042939706 0.422834509449219 no 1966 0.348895429981089 3208 2273927 SGTC_2998 9066762 71.4286 µM -0.388845694480948 0.422641346349996 no 1967 0.348695148153382 3274 4945196 SGTC_67 0335-0847 266 µM -0.393235912568537 0.421075677199128 no 1968 0.34707262370857 3368 4552207 YOR254C SEC63 SGTC_1030 k029-0042 36.7 µM -0.393401359121272 0.421016698769192 no 1969 0.347011532993631 3132 6080581 SGTC_3130 9127414 49.47 µM -0.393475140061937 0.420990397891759 no 1970 0.346984290852514 3175 1494646 SGTC_3239 9133757 49.47 µM -0.39381643882191 0.420868738854622 no 1971 0.346858283383689 3103 17036923 SGTC_2337 9009472 200 µM -0.394735928999907 0.420541015878904 no 1972 0.346518892007144 3297 5742383 SGTC_2153 5569715 200 µM -0.395100870042376 0.420410959525633 no 1973 0.34638422339928 3152 2054701 SGTC_521 r062-0005 13.8 µM -0.395849773365634 0.420144095323989 no 1974 0.346107927888876 3084 2832033 SGTC_1559 coumarin 343 70.1 µM -0.396556332837212 0.41989235358113 no 1975 0.345847329522506 3257 108770 A hepatotoxic, DNA x-linker. SGTC_3162 9099653 49.47 µM -0.397418726553539 0.419585133711312 no 1976 0.345529354191223 3237 25237511 SGTC_1376 2910-0861 41.3 µM -0.399007657121514 0.419019220200203 no 1977 0.344943781120756 3130 1112859 SGTC_439 amiodarone 34.4 µM -0.399924389017573 0.418692793093725 no 1978 0.344606104077842 3109 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_508 roscovitine 141 µM -0.400445370545667 0.418507308505568 no 1979 0.344414256330529 3114 160355 A CDKinase inhibitor. SGTC_1190 1486-1332 13 µM -0.401187714655502 0.418243043706164 no 1980 0.344140962534443 3160 4150046 SGTC_597 k018-0003 82.8 µM -0.401708746564435 0.418057585190062 no 1981 0.343949193365856 3234 6786234 SGTC_1531 st059297 52.4 µM -0.402259395699664 0.417861604383485 no 1982 0.343746567006728 3221 7566702 SGTC_139 0099-0334 718.624 µM -0.40356925184247 0.417395497264737 no 1983 0.343264750174224 3110 97690 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.404216460539827 0.417165233410009 no 1984 0.343026775195522 3267 688798 SGTC_2629 bisabolol 100 µM -0.404400347366011 0.417099815349837 no 1985 0.342959172401346 3266 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.404558411311955 0.417043585658672 no 1986 0.34290106695769 3134 115019 SGTC_3203 9113543 49.47 µM -0.405017737239014 0.416880194620473 no 1987 0.342732236533211 3241 17018012 SGTC_3046 9092212 49.47 µM -0.405545413833126 0.416692507661201 no 1988 0.342538321815253 3186 25236637 SGTC_2742 clothiapine 36.27 µM -0.405716976579097 0.416631489353613 no 1989 0.34247528353292 3172 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3041 9091929 49.47 µM -0.406293227931058 0.416426553497914 no 1990 0.342263580326485 3296 25236887 SGTC_1560 lithocholic acid 53.1 µM -0.406506793083331 0.416350607759722 no 1991 0.342185133350615 3187 9903 A bile acid which acts as a detergent. SGTC_541 4513-1321 94 µM -0.406974427804309 0.41618432344818 no 1992 0.342013385060133 3144 747515 SGTC_3263 9137018 49.47 µM -0.40749456400245 0.415999387975278 no 1993 0.34182239293704 3174 43844957 SGTC_1563 conessine 56.1 µM -0.408244006015629 0.415732955073093 no 1994 0.34154727173984 3211 441082 An anti-amoebic, histamine inhibitor. SGTC_3299 9121982 43.1275 µM -0.408551624120978 0.415623605469117 no 1995 0.341434369064008 3128 17594604 YPL160W CDC60 SGTC_1868 st057644 42.7 µM -0.40993198832415 0.415133005285442 no 1996 0.340927919555639 3087 688665 SGTC_1174 0739-0097 51.1 µM -0.410918578171741 0.414782438882143 no 1997 0.340566119627278 3139 728447 SGTC_552 k242-0005 476 µM -0.411302049351931 0.414646197808127 no 1998 0.340425533531111 3253 4088318 SGTC_2910 7948405 25.97 µM -0.411646333610809 0.414523887956167 no 1999 0.340299332817126 3262 2971328 SGTC_700 3453-2283 142 µM -0.411917654293497 0.414427504860943 no 2000 0.340199890205397 3295 565664 SGTC_2207 7258803 200 µM -0.411925600765473 0.41442468205918 no 2001 0.340196977886002 3210 3666799 SGTC_2757 clomiphene 4.22 µM -0.412182068262473 0.41433358024201 no 2002 0.340102989687881 3324 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_773 4358-1457 44.6 µM -0.413010772802899 0.414039241176464 no 2003 0.339799360485856 3266 1186886 SGTC_36 0335-0881 14.2 µM -0.415285018342642 0.413231723753824 no 2004 0.338966633621849 3177 23828853 SGTC_812 4251-0442 148 µM -0.4166642477699 0.412742178635217 no 2005 0.33846200427673 3254 5723007 SGTC_1705 st027868 56.3335 µM -0.416844802747236 0.412678102292653 no 2006 0.338395964673336 3197 292948 SGTC_1723 st034307 2.5525 µM -0.421724601576561 0.410947219145603 no 2007 0.336613022664578 3195 867466 SGTC_3170 9103054 49.47 µM -0.423216825544231 0.410418265977902 no 2008 0.336068535962102 3216 16432970 SGTC_1539 benzyladenosine 56 µM -0.42909501157043 0.408336201137647 no 2009 0.333927041203665 3145 92208 A nucleotide analog. SGTC_1348 1493-0373 93.8 µM -0.429854957532549 0.408067214275988 no 2010 0.333650576158436 3200 3010129 SGTC_2298 7976326 193.81 µM -0.431521189473206 0.40747759452148 no 2011 0.333044724421652 3178 2235818 SGTC_511 blebbistatin 171 µM -0.432231938613463 0.407226149557369 no 2012 0.332786424264815 3315 3476986 A myosin inhibitor. SGTC_2340 7987427 183.45 µM -0.432563205589167 0.407108968782975 no 2013 0.332666062458856 3270 2239331 SGTC_2576 guaiol 23.12 µM -0.433878844521044 0.406643663220737 no 2014 0.332188211498096 3210 227829 SGTC_1428 4049-0204 61.7 µM -0.433911713387389 0.406632040084806 no 2015 0.332176276742182 3274 X1428 SGTC_1527 coumarin 137 µM -0.434070139933987 0.406576018214747 no 2016 0.332118754110708 3315 323 A hepatotoxic, DNA x-linker. SGTC_2005 4024620 188 µM -0.434077984020824 0.406573244484245 no 2017 0.332115906126923 3184 236743 SGTC_2854 9024559 71.43 µM -0.434507899503532 0.406421230177035 no 2018 0.33195982983813 3237 3163529 SGTC_706 4262-0057 46.9 µM -0.434769277352891 0.406328816176375 no 2019 0.331864953610761 3158 883298 SGTC_865 0488-0499 301 µM -0.435149621533535 0.406194349193354 no 2020 0.331726913654427 3323 9634651 SGTC_2175 5807670 165.306 µM -0.435910159977079 0.405925501424617 no 2021 0.331450956679624 3272 241186 SGTC_1382 3002-2117 298 µM -0.436332986480861 0.40577605286344 no 2022 0.331297576083975 3321 1497314 SGTC_573 3702-0553 84.7 µM -0.437214585591629 0.405464494733448 no 2023 0.330977866446736 3185 1222756 SGTC_819 1013-0258 27.7 µM -0.437500747665723 0.405363377595426 no 2024 0.330874116987937 3181 5753198 SGTC_2987 9018338 71.43 µM -0.438726307274591 0.404930390061344 no 2025 0.330429931372889 3321 5055682 SGTC_1421 4029-0249 71.4 µM -0.439400907218689 0.404692104993558 no 2026 0.330185534638455 3318 2894095 SGTC_298 1391-0729 10 µM -0.439867366318589 0.404527360983411 no 2027 0.330016586344626 3165 3237558 SGTC_2127 5253358 187.912 µM -0.440489303120436 0.404307731695138 no 2028 0.329791379012628 3112 20612 SGTC_2961 9083290 32.55 µM -0.443205385304894 0.403348935134261 no 2029 0.328808591996728 3258 17741490 SGTC_1312 1218-2183 165 µM -0.443415228261396 0.403274883151696 no 2030 0.32873271156186 3284 6744073 SGTC_3154 9100113 49.47 µM -0.444644507145803 0.402841149740336 no 2031 0.328288339069202 3174 25237525 SGTC_489 paxilline 115 µM -0.444752580686701 0.402803023251547 no 2032 0.328249283128375 3249 105008 A toxic potassium channel blocker. SGTC_2371 9071574 200 µM -0.448347852937941 0.401535201894411 no 2033 0.32695108505392 3276 45596039 SGTC_769 0302-0231 76 µM -0.448797134943146 0.401376841552722 no 2034 0.326789002858863 3293 571869 YER009W NTF2 SGTC_2686 alizarin 95.37 µM -0.448950288001852 0.401322862742518 no 2035 0.326733759094787 3204 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.449407111508311 0.401161866443782 no 2036 0.326569001079454 3276 4213774 SGTC_2262 9014885 67.46 µM -0.450952907272578 0.400617213060043 no 2037 0.326011745223154 3177 6457424 SGTC_2352 9027995 87.8 µM -0.451036327894781 0.400587825706378 no 2038 0.325981683312567 3240 2997347 SGTC_1249 0481-0015 10.2 µM -0.453754521797102 0.399630571214449 no 2039 0.325002759963852 3146 4227577 SGTC_2886 9058944 51.95 µM -0.453880225752756 0.399586317144435 no 2040 0.324957518412331 3177 4949929 SGTC_2433 5607874 27.82 µM -0.454979699203055 0.399199302627145 no 2041 0.324561921895844 3188 2252428 SGTC_137 0438-0332 85.389 µM -0.458009842299729 0.398133206394016 no 2042 0.32347268509192 3320 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2049 5262831 67.185 µM -0.459306472637712 0.397677244243429 no 2043 0.323007050173902 3261 763417 SGTC_2917 7979103 53.79 µM -0.45944099559073 0.39762994702091 no 2044 0.322958757291319 3326 2980565 SGTC_2764 methyldopa 94.69 µM -0.460868958540723 0.397127979267731 no 2045 0.322446311826344 3379 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_332 4112-0506 40.9 µM -0.46168504146053 0.396841180408311 no 2046 0.322153599830345 3214 2790355 SGTC_2621 lithochol-11-enic acid 100 µM -0.462021715508629 0.396722878122944 no 2047 0.322032873960436 3343 6708711 SGTC_2792 7535235 81.82 µM -0.462282041865972 0.396631409803735 no 2048 0.321939538010463 3228 1281891 SGTC_1418 3966-3099 2.4 µM -0.464807196313272 0.395744466937846 no 2049 0.321034766933253 3307 740335 SGTC_1040 k898-0338 155 µM -0.46809297309724 0.394591169232161 no 2050 0.319859052063996 3380 20969351 SGTC_252 miconazole 1.30953 nM -0.469142355583977 0.394223033187271 no 2051 0.319483942806972 3290 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3260 9137109 49.47 µM -0.469276214817566 0.394176080539534 no 2052 0.319436107139544 3248 17478346 SGTC_31 0508-1974 57.237 µM -0.470427165737905 0.393772434946241 no 2053 0.319024929684553 3312 6810525 SGTC_1036 k216-0215 33.5 µM -0.470784355065041 0.393647189625166 no 2054 0.31889736895759 3268 622330 SGTC_3137 9097352 49.47 µM -0.470789422974876 0.393645412685927 no 2055 0.318895559241837 3470 44120435 SGTC_1620 st003704 16.5 µM -0.470892516814074 0.393609265821194 no 2056 0.31885874607813 3351 2834414 SGTC_1954 st077032 68.9 µM -0.47120085358263 0.393501161948558 no 2057 0.318748654608324 3285 698907 SGTC_2466 5983409 37.09 µM -0.47377394140401 0.392599349842822 no 2058 0.317830559466373 3259 2879657 SGTC_276 colchicine 750 µM -0.474215247526724 0.392444739275152 no 2059 0.317673210695327 3369 2833 A microtubule depolymerizer. SGTC_866 0495-0101 262 µM -0.47523480607096 0.392087604271126 no 2060 0.317309810562842 3233 635694 SGTC_2986 9022445 71.43 µM -0.475905251863245 0.39185280737938 no 2061 0.317070940226528 3342 6459286 SGTC_2105 5350118 200 µM -0.476655897940079 0.391589970271233 no 2062 0.316803586091736 3279 2133313 SGTC_3265 9137266 49.47 µM -0.476870820802771 0.39151472460024 no 2063 0.316727055618806 3282 17224265 SGTC_1673 st016611 27.3 µM -0.47781730991692 0.391183401912577 no 2064 0.316390119879026 3360 5226799 SGTC_838 0109-0203 71.4 µM -0.478175169868942 0.39105815201384 no 2065 0.316262766851502 3281 759422 SGTC_884 0851-0618 334 µM -0.478520779254927 0.390937200500573 no 2066 0.316139794165504 3330 9642473 SGTC_1740 st038286 13.222 µM -0.479254465620261 0.390680470243606 no 2067 0.315878805647467 3397 716786 SGTC_1800 st050079 29.0735 µM -0.479397511643516 0.390630421374928 no 2068 0.315827931688353 3308 3645560 SGTC_831 k061-1017 217 µM -0.479764663927058 0.390501970619314 no 2069 0.315697370870406 3306 1240153 SGTC_1086 cerivastatin 2.18 µM -0.4804831732704 0.390250629763994 no 2070 0.315441932627157 3315 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1368 1852-0141 284 µM -0.482151117937975 0.389667345109972 no 2071 0.314849299408201 3332 2838987 SGTC_3210 9128157 49.47 µM -0.484339344944332 0.38890249326119 no 2072 0.314072528670621 3263 17590849 SGTC_1997 st073024 93.8 µM -0.48528823019094 0.388570962628776 no 2073 0.313735951618216 3350 686268 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.48558252104088 0.38846815694391 no 2074 0.313631595811771 3194 688667 SGTC_1820 st053765 18.6 µM -0.486625616536725 0.388103831595316 no 2075 0.313261833329776 3316 3690829 SGTC_997 3996-0078 137 µM -0.487707770429005 0.38772596824776 no 2076 0.312878423520704 3287 735687 SGTC_1246 0422-0085 105 µM -0.489035685709259 0.387262435941679 no 2077 0.312408216309961 3387 264295 SGTC_2765 myclobutanil 7.74 µM -0.489378653352889 0.387142743107334 no 2078 0.312286823003001 3367 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2445 5742597 35.57 µM -0.489674747828204 0.387039417245871 no 2079 0.312182036827976 3219 1774255 SGTC_2927 9011802 47.9 µM -0.489836969841294 0.386982811243853 no 2080 0.312124633808071 3345 43912568 SGTC_2517 totarol 10 µM -0.490295448035663 0.386822842148643 no 2081 0.311962423815299 3319 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_102 gallobenzophenone 83.616 µM -0.490712798664172 0.386677239719338 no 2082 0.311814796491146 3399 70837 SGTC_606 k015-0008 38.6 µM -0.493790683708994 0.385603942093749 no 2083 0.310727006652544 3383 1970475 SGTC_2586 curcumin 80 µM -0.495165547801919 0.385124791853626 no 2084 0.310241633846693 3357 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_705 1124-0212 310 µM -0.495174857356343 0.385121548002331 no 2085 0.310238348389126 3397 9554485 SGTC_1306 1185-0270 9.02 µM -0.495235318699873 0.385100480851624 no 2086 0.310217011197454 3352 1548076 SGTC_628 1636-0253 16 µM -0.495761743750776 0.384917067642833 no 2087 0.310031259461567 3315 4456143 SGTC_3253 9135987 49.47 µM -0.498103699339037 0.384101413024956 no 2088 0.309205476640353 3360 4182430 SGTC_1504 k297-0033 30 µM -0.498681074657767 0.383900403856034 no 2089 0.309002039616594 3197 4388117 SGTC_1861 st057647 17.4 µM -0.503215795798286 0.382322762396775 no 2090 0.307406280195859 3421 688668 SGTC_1014 4130-3005 69.3 µM -0.504916883841011 0.381731451272315 no 2091 0.3068086074898 3263 743608 SGTC_1172 0370-0043 85 µM -0.505372680688274 0.381573059629586 no 2092 0.306648551604931 3387 376585 SGTC_3206 9114350 49.47 µM -0.507598370089353 0.380799906908802 no 2093 0.305867516959333 3342 17087243 SGTC_1101 ebselen 5.29 µM -0.508066773827589 0.380637254840047 no 2094 0.305703257850658 3429 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2345 9052315 157.45 µM -0.508727156110746 0.380407974527563 no 2095 0.305471742402832 3360 6469265 SGTC_2221 6807166 181.081 µM -0.510342073374741 0.379847463172905 no 2096 0.304905915826421 3346 674925 SGTC_1967 st070177 51.4 µM -0.512243712203788 0.379187759019397 no 2097 0.30424022690306 3432 5729214 SGTC_10 0279-0212 42.575 µM -0.512372860289715 0.379142968538606 no 2098 0.304195040723637 3345 39851 YBR002C RER2 SGTC_3192 9110362 49.47 µM -0.513340445163639 0.378807447337748 no 2099 0.303856598426667 3424 16649480 SGTC_2263 7948595 193.29 µM -0.516397932087248 0.377747829765607 no 2100 0.302788254890826 3350 2971371 SGTC_69 0096-0274 206.684 µM -0.517073684958306 0.377513761319727 no 2101 0.302552361271274 3544 6741392 SGTC_94 0334-0113 514.748 µM -0.517091227101716 0.377507685640438 no 2102 0.302546238710021 3348 6795178 SGTC_1359 1582-0056 520 nM -0.517872725629549 0.377237046276142 no 2103 0.302273536357573 3403 3661189 SGTC_2605 digitonin 300 nM -0.518073683417186 0.377167462681396 no 2104 0.302203430368992 3484 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_634 1611-4317 11.2 µM -0.518106387686837 0.37715613888622 no 2105 0.302192021871588 3438 2843522 SGTC_1949 st076024 69.1 µM -0.518727363389066 0.376941147210446 no 2106 0.301975438539101 3245 2921930 SGTC_2480 5767542 37.17 µM -0.519788183065253 0.376573962829901 no 2107 0.301605608227657 3315 2867358 SGTC_1071 trifluoperazine 6.31 µM -0.521610915922693 0.375943316259447 no 2108 0.300970630718675 3448 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_378 3970-0959 8.33 µM -0.521693264154283 0.375914832436421 no 2109 0.300941957658928 3404 6615653 SGTC_1919 st067113 52.3 µM -0.523554840017811 0.375271103739576 no 2110 0.300294099320841 3396 1268243 SGTC_1447 4239-0816 81.9 µM -0.523764971577453 0.37519846249886 no 2111 0.300221009769061 3338 1341554 SGTC_537 1334-0398 209 µM -0.52449414134255 0.374946427152397 no 2112 0.299967446814521 3428 5846986 SGTC_1007 4101-0031 70 µM -0.525764510911004 0.374507455314842 no 2113 0.299525917617436 3422 1146276 SGTC_2692 st077426 47.7 µM -0.528271297303122 0.373641721363481 no 2114 0.298655525141221 3434 25238571 SGTC_1701 st028638 40.4 µM -0.528849290269132 0.373442198215173 no 2115 0.298455000895897 3426 3490878 SGTC_1031 k035-0009 16 µM -0.52899907882862 0.373390496743237 no 2116 0.298403044451186 3444 5180959 SGTC_1338 1486-1223 76 µM -0.529725833184468 0.373139680383699 no 2117 0.29815101708463 3380 3444526 SGTC_1440 4100-1550 40 µM -0.531495901775708 0.37252902207823 no 2118 0.297537590246622 3388 742806 SGTC_196 k015-0023 18.111 µM -0.531526462151157 0.372518481822269 no 2119 0.297527004444844 3360 5211998 SGTC_2519 cryptotanshinone 88.04 µM -0.533956869067497 0.371680542205603 no 2120 0.296685687524084 3447 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1065 prochlorperazine maleate 2.48 µM -0.534339552670506 0.371548658351353 no 2121 0.296553315959318 3445 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1608 st001473 40.5 µM -0.535750573901164 0.37106250995378 no 2122 0.296065472879698 3308 7292267 SGTC_1202 1988-0068 29.6 µM -0.536028476837224 0.37096678645451 no 2123 0.295969434819369 3320 2850480 SGTC_1369 1866-0067 208 µM -0.536371326974275 0.370848702932375 no 2124 0.295850971931453 3449 3531355 SGTC_2915 7971052 15.16 µM -0.539038376073597 0.369930541140007 no 2125 0.294930187512198 3350 5741558 SGTC_3196 9111891 49.47 µM -0.53904290741649 0.36992898180303 no 2126 0.294928624214655 3424 18891510 SGTC_2670 beta-carotene 100 µM -0.539760449659938 0.369682086379099 no 2127 0.294681122827176 3412 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_752 1896-0090 130 µM -0.539836239845627 0.36965601125838 no 2128 0.294654986161387 3421 772567 SGTC_2086 5274770 176.623 µM -0.540148021694417 0.369548751045889 no 2129 0.294547477710871 3391 689278 SGTC_2659 sanguinarine 24.21 µM -0.540493072068504 0.369430057520547 no 2130 0.294428518730037 3337 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_284 0988-0104 32.6 µM -0.541194148300367 0.369188933362296 no 2131 0.294186885215537 3402 4666532 SGTC_307 1501-1223 22.3 µM -0.541648253392341 0.369032778502864 no 2132 0.294030421887993 3415 2830329 SGTC_641 4092-0595 30 µM -0.542174947985165 0.368851689086279 no 2133 0.293848995820796 3438 786260 SGTC_218 alverine citrate 93.75 µM -0.542307270461375 0.368806198224712 no 2134 0.293803423948029 3461 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_836 0330-0104 1.35 µM -0.543681066058965 0.368334012681295 no 2135 0.293330481940568 3421 46494820 SGTC_2462 5162487 171.77 µM -0.544640466493307 0.368004376217843 no 2136 0.293000408719519 3422 2259986 SGTC_2261 9010538 184.68 µM -0.546513229862652 0.36736120129393 no 2137 0.292356598062387 3403 6457250 SGTC_1865 st057639 52.2 µM -0.548096186935531 0.366817846340339 no 2138 0.29181292932993 3418 688818 SGTC_2011 4012611 177 µM -0.5481882806113 0.366786243098963 no 2139 0.291781314137245 3361 2049887 SGTC_3310 9130229 44.1445 µM -0.55119497545467 0.36575495053864 no 2140 0.290750012038131 3442 7761258 SGTC_958 1222-0007 33 µM -0.553137698838204 0.365089113904041 no 2141 0.290084561974514 3516 7312461 SGTC_24 0417-1663 219 µM -0.553745155489632 0.364881001421403 no 2142 0.289876633620923 3445 4329390 SGTC_2513 baicalein 25.65 µM -0.554641783566256 0.364573892586136 no 2143 0.289569851623713 3398 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1640 st009078 66.4 µM -0.556211230843451 0.364036542152572 no 2144 0.289033231265262 3452 690618 SGTC_3072 9116419 49.47 µM -0.556243966292621 0.364025336966708 no 2145 0.289022043447805 3402 17170162 SGTC_259 usnic acid 108.925 µM -0.556350152309428 0.363988990807131 no 2146 0.2889857542292 3519 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1756 st041558 35.5 µM -0.556607813921423 0.363900801512789 no 2147 0.288897706928485 3525 3955792 SGTC_2828 7998861 71.43 µM -0.558244142335599 0.363340907278615 no 2148 0.288338840907314 3421 2988188 SGTC_232 clozapine 119 µM -0.558802151748486 0.363150042683311 no 2149 0.288148376900484 3416 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1978 st071761 42 µM -0.559231421182086 0.36300323613711 no 2150 0.288001895809275 3367 5147680 SGTC_2470 5664817 21.68 µM -0.560472041015714 0.362579067775214 no 2151 0.28757875253063 3468 2859561 SGTC_3323 9138564 53.9225 µM -0.560753910847426 0.362482719866757 no 2152 0.28748265502258 3503 43912313 YNL103W MET4 SGTC_678 1218-2179 85.9 µM -0.560976190922753 0.362406746893108 no 2153 0.28740688408196 3434 6820081 YOR116C RPO31 SGTC_1467 k284-1082 293 µM -0.56189258975592 0.362093588732586 no 2154 0.287094601392732 3459 3334705 SGTC_848 0368-0089 85.6 µM -0.56190748470745 0.362088499488196 no 2155 0.287089526943603 3448 762535 SGTC_3040 9091894 49.47 µM -0.562076340157388 0.362030807373375 no 2156 0.287032003818983 3392 25236966 SGTC_1268 0828-0275 2.46 µM -0.56214672191153 0.362006761267867 no 2157 0.287008028837811 3464 745337 SGTC_2077 5212015 200 µM -0.562730062001423 0.361807482614482 no 2158 0.286809355224208 3405 780900 SGTC_2090 5301565 104.445 µM -0.562975804271861 0.361723544190799 no 2159 0.286725679988964 3427 2056344 SGTC_1021 4476-0760 85.3 µM -0.563191568737546 0.361649850799403 no 2160 0.286652221738602 3370 746768 SGTC_3094 9117742 49.47 µM -0.563699606287865 0.361476353107548 no 2161 0.286479292695098 3430 17149698 SGTC_1960 st011366 51.8 µM -0.564136609881024 0.361327136696781 no 2162 0.286330582254656 3467 3972846 SGTC_3165 9101544 49.47 µM -0.565432116485734 0.360884905450679 no 2163 0.285889942425022 3463 5002184 SGTC_2537 larixol 68.93 µM -0.566220414810963 0.360615904637382 no 2164 0.285621976890081 3490 6708759 SGTC_1183 1254-0324 198 µM -0.566783908173159 0.360423659065367 no 2165 0.285430502385936 3481 5799357 SGTC_2522 biochanin a 4.94 µM -0.567233911941196 0.360270157778757 no 2166 0.285277635446644 3476 5280373 A possible chelator. SGTC_913 3487-1245 167 µM -0.567752095401921 0.360093427541332 no 2167 0.285101656097202 3378 4016153 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.568689440654416 0.359773815106095 no 2168 0.284783457501826 3448 521171 SGTC_86 0417-1630 471.922 µM -0.569669364395573 0.359439789235851 no 2169 0.284450986183032 3485 3634867 SGTC_586 0957-0265 8.15 µM -0.569755865956349 0.359410308667823 no 2170 0.284421646596156 3419 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2206 7254556 146.969 µM -0.570278303266874 0.359232274778118 no 2171 0.284244477128743 3429 4398905 SGTC_2166 5933061 31.504 µM -0.570333162689721 0.359213581797613 no 2172 0.284225876207342 3722 2877375 SGTC_2778 tioconazole 65.09 nM -0.570369049381502 0.359201353830344 no 2173 0.284213708593743 3440 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_976 1348-1067 47.6 µM -0.570463771437708 0.359169079098846 no 2174 0.284181593667789 3473 5310671 YGL099W LSG1 SGTC_2471 5466956 24.79 µM -0.571853216074712 0.358695767981681 no 2175 0.283710710597557 3381 724419 SGTC_1245 0418-0076 17.2 µM -0.571952012958528 0.358662121302879 no 2176 0.283677242548299 3474 6790114 SGTC_556 4058-0063 51.5 µM -0.572797915314357 0.358374082195748 no 2177 0.283390765382839 3461 6615692 SGTC_1897 st060201 15 µM -0.57351717349013 0.358129230199741 no 2178 0.283147287273992 3440 611878 SGTC_2681 menadione 3.18 µM -0.573568043387134 0.358111915126688 no 2179 0.283130070963154 3501 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_759 3486-0358 89.3 µM -0.574976453117664 0.357632637252383 no 2180 0.282653611046109 3527 875103 SGTC_1415 3966-0071 78.1 µM -0.578484475573709 0.35643984405029 no 2181 0.281468537797075 3483 2893185 SGTC_472 calcifediol 10 µM -0.578841475283202 0.356318535935033 no 2182 0.281348071380709 3460 5283731 A vitamin D metabolite. SGTC_363 0455-0021 3.06 µM -0.582060075357128 0.355225516815386 no 2183 0.280263108109857 3497 4597466 SGTC_822 1487-0950 154 µM -0.582661333552931 0.355021464441476 no 2184 0.280060653864048 3513 1958375 SGTC_3328 9140624 29.0385 µM -0.583343410819467 0.354790034378565 no 2185 0.279831072265284 3505 4904392 SGTC_3039 9090270 49.47 µM -0.583540527201646 0.354723162405561 no 2186 0.279764741519507 3519 17173750 SGTC_1650 st011916 45.8 µM -0.588311095125894 0.353106110969784 no 2187 0.278161749852107 3510 242528 SGTC_265 mycophenolic acid 32.932 µM -0.588724560131413 0.352966085494895 no 2188 0.278023029822513 3602 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1652 st011932 78 µM -0.590199292041481 0.352466810007713 no 2189 0.277528523358458 3484 1551076 SGTC_420 mitomycin C 81.9 mM -0.590497639712686 0.352365834266053 no 2190 0.277428533846791 3476 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_116 0155-0182 31.788 µM -0.590627942775867 0.352321736470513 no 2191 0.277384869048182 3465 771486 SGTC_3074 9116018 49.47 µM -0.591055645239507 0.352177005280773 no 2192 0.277241568777395 3488 17027303 SGTC_3234 9132280 49.47 µM -0.591138858718349 0.352148848973357 no 2193 0.277213692590001 3517 17612295 SGTC_1149 3909-7961 23.3 µM -0.591536899849848 0.352014178057837 no 2194 0.277080369348853 3475 735261 SGTC_2926 9010726 65.15 µM -0.591972788514656 0.351866723319854 no 2195 0.276934405144113 3491 2994293 SGTC_365 0121-0052 13.6 µM -0.592072837742044 0.351832881277296 no 2196 0.2769009073932 3506 3101739 SGTC_1457 k015-0032 57.3 µM -0.592127991195196 0.351814225907911 no 2197 0.276882442165607 3510 4302660 SGTC_1817 st052116 64.4 µM -0.592294792504636 0.351757808401627 no 2198 0.276826601206183 3516 4361398 SGTC_1435 4092-0789 56.7 µM -0.593360493260615 0.351397431621244 no 2199 0.276469961167671 3518 2248285 SGTC_2725 haloperidol 53.21 µM -0.593410569207967 0.351380501249043 no 2200 0.276453208641344 3478 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2791 5663188 71.43 µM -0.593948762451273 0.351198560019186 no 2201 0.276273191627075 3498 54690634 SGTC_247 mechlorethamine 29.705 µM -0.597963267717152 0.349842497517355 no 2202 0.274932221448062 3464 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1983 st071813 46.9 µM -0.601703695975467 0.34858073665379 no 2203 0.273685694674102 3482 11838595 SGTC_3127 9126946 49.47 µM -0.602171465771396 0.348423061026256 no 2204 0.273530003666706 3441 27243249 SGTC_1102 cgs 12066b 26.1 µM -0.602256661357307 0.348394346155833 no 2205 0.273501652159262 3478 6438352 A 5-HT1B full agonist. SGTC_1456 k015-0012 13 µM -0.602274021022104 0.348388495248863 no 2206 0.273495875363883 3597 2989616 SGTC_3296 9122258 64.045 µM -0.60263292162305 0.348267539360204 no 2207 0.273376457136986 3505 4730474 SGTC_2813 7971799 71.43 µM -0.602800526149333 0.348211058937481 no 2208 0.273320698354263 3520 2234054 SGTC_2133 5320837 200 µM -0.60435923092669 0.347685958214686 no 2209 0.272802417361627 3520 2841355 SGTC_2155 5570423 76 µM -0.605699817069078 0.347234571460235 no 2210 0.272357052761038 3446 797402 SGTC_3257 9139206 32.98 µM -0.607695235199462 0.346563098515188 no 2211 0.271694811909148 3507 4910041 SGTC_77 0828-0286 12.516 µM -0.60876537158965 0.346203188054308 no 2212 0.271339984758064 3523 745345 SGTC_674 0498-0004 451 µM -0.610150696736744 0.34573747892113 no 2213 0.270880993105783 3483 4231473 SGTC_544 k015-0020 52.4 µM -0.610382040128368 0.345659730199108 no 2214 0.27080438123041 3525 3008304 SGTC_1082 camptothecin 424.86 nM -0.612259924999347 0.345028861235771 no 2215 0.270182899784524 3448 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1100 amiodarone 5.07 µM -0.612818521474032 0.344841285667822 no 2216 0.269998171382135 3567 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1039 k821-0043 94 µM -0.613146410650021 0.34473119890165 no 2217 0.269889767555943 3533 15992768 SGTC_1272 0839-0021 27 µM -0.613539739132086 0.344599158636347 no 2218 0.269759757513894 3524 5027250 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.613629031827704 0.344569185738669 no 2219 0.269730247246322 3541 61125 An anti-inflammatory. SGTC_638 3970-0837 4.09 µM -0.614400371924933 0.344310310488537 no 2220 0.269475395035323 3501 4118451 YLR208W SEC13 SGTC_3092 9117248 49.47 µM -0.61450304720574 0.34427585636274 no 2221 0.269441480034809 3556 17141857 SGTC_1649 st011737 51.3 µM -0.615497170281681 0.343942331339557 no 2222 0.269113218749715 3505 1761035 SGTC_173 1273-0061 2.693 µM -0.61552474867776 0.343933080607696 no 2223 0.26910411517364 3491 2847414 YPL266W DIM1 SGTC_707 0865-0008 204 µM -0.616637764428743 0.343559815296587 no 2224 0.268736839808504 3543 723043 SGTC_1485 3909-9022 254 µM -0.617379996551878 0.343310982161216 no 2225 0.268492056466259 3560 714516 SGTC_1999 st074831 12.5 µM -0.61760744738608 0.343234742914228 no 2226 0.268417067100113 3471 17112523 SGTC_1887 st057648 70.8 µM -0.618094243701608 0.343071595094911 no 2227 0.26825660826681 3549 688672 SGTC_194 1486-1323 56.904 µM -0.619148287416422 0.342718436868504 no 2228 0.26790933759618 3523 5178754 SGTC_1637 st007924 17.4 µM -0.619222722612684 0.342693502484964 no 2229 0.267884822354835 3556 683336 SGTC_1914 st062367 72.6 µM -0.621700711772105 0.341863814723653 no 2230 0.267069341760586 3510 978205 SGTC_2388 9080168 200 µM -0.626211837681538 0.340355347506654 no 2231 0.265588001880972 3505 15943073 SGTC_1276 0871-0068 94.2 µM -0.626255454678917 0.340340774911258 no 2232 0.265573699527539 3512 3414906 SGTC_3028 9087778 49.47 µM -0.627271866136633 0.340001255747223 no 2233 0.265240520947749 3483 17217395 SGTC_204 PMA1.184 62.41 µM -0.627681876658796 0.339864333711937 no 2234 0.265106180037751 3572 2252213 YGL008C PMA1 SGTC_2796 7949634 45.45 µM -0.62794796152507 0.339775486607086 no 2235 0.26501901520262 3545 2971588 SGTC_500 h-89 112 µM -0.629833042069178 0.339146303660825 no 2236 0.264401912432898 3610 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_683 panaxydol 45 µM -0.631742957654877 0.338509288690058 no 2237 0.26377742640941 3557 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1173 0443-0020 122 µM -0.631779310173927 0.338497168491568 no 2238 0.263765547507201 3558 5331295 SGTC_1409 3909-8004 61.9 µM -0.632174894588165 0.338365288542026 no 2239 0.263636300141068 3561 2119279 SGTC_2662 daunorubicin 22.37 µM -0.632234026326168 0.338345576903358 no 2240 0.263616983092932 3488 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2290 7904846 200 µM -0.632671449382069 0.33819977514418 no 2241 0.263474108960867 3559 2962154 SGTC_2322 7413319 38.22 µM -0.633133779494412 0.338045697742922 no 2242 0.263323142489749 3584 1840400 SGTC_2884 9058502 51.95 µM -0.633209557034503 0.338020446498755 no 2243 0.263298402765282 3570 6471554 SGTC_1963 st076565 50.3 µM -0.634006426917143 0.337754950804926 no 2244 0.263038313912591 3583 4914280 SGTC_1921 5740136 50 µM -0.634955522336605 0.33743884295823 no 2245 0.262728711872318 3590 1774243 SGTC_2677 mitomycin C 100 µM -0.635495347846818 0.337259098617613 no 2246 0.262552699948631 3578 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_662 k832-1615 104 µM -0.639343464848604 0.335978878835569 no 2247 0.261299759323151 3560 5878478 SGTC_465 cgp-37157 41 µM -0.639557870523956 0.335907604545985 no 2248 0.261230039632254 3495 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1345 1488-0192 31.4 µM -0.641536863180635 0.335250012335854 no 2249 0.260586969273459 3602 658348 SGTC_1304 1165-0502 251 µM -0.641661593281084 0.335208583109735 no 2250 0.260546465753292 3561 767425 SGTC_375 3970-0961 9.27 µM -0.643597801217515 0.334565727061005 no 2251 0.259918138221181 3526 2898222 SGTC_2312 7706453 155.7 µM -0.647063572527392 0.333416239533381 no 2252 0.25879540000756 3604 976098 SGTC_1282 0886-0010 32.4 µM -0.647192466114632 0.333373519648581 no 2253 0.258753693328365 3654 2836211 YNL267W PIK1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.649137984072887 0.33272896908945 no 2254 0.258124596101243 3607 688669 SGTC_1136 pergolide 1.05886 µM -0.649791340226325 0.332512622769861 no 2255 0.257913506715159 3583 47811 A dopamine receptor agonist. SGTC_2611 pyromycin 23.93 µM -0.650166840684813 0.332388308254067 no 2256 0.257792228798161 3574 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_745 0469-0705 296 µM -0.652007586777054 0.331779171234611 no 2257 0.257198139073929 3680 3486736 SGTC_3065 9113888 49.47 µM -0.652101531422402 0.331748095116829 no 2258 0.257167838107053 3655 16648368 SGTC_3238 9133470 49.47 µM -0.65536886836136 0.330668008504409 no 2259 0.256115145133408 3620 3534688 SGTC_1151 3909-8316 15.3 µM -0.65554402353418 0.330610146994984 no 2260 0.256058775974974 3620 800431 SGTC_1870 st057514 26.5 µM -0.657317327088902 0.330024574463684 no 2261 0.255488448748545 3593 5393161 SGTC_3201 9113999 49.47 µM -0.657354220602039 0.330012396064212 no 2262 0.255476590163913 3590 16649224 SGTC_287 k060-0039 29.6 µM -0.657883697115217 0.329837637858163 no 2263 0.255306433609754 3638 5861974 SGTC_1874 staurosporine 7.6 µM -0.658212279089476 0.329729205267103 no 2264 0.255200867833015 3610 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1324 1418-0026 34.4 µM -0.658212632829871 0.329729088539901 no 2265 0.255200754196721 3632 1372513 SGTC_1626 st003712 1.76 µM -0.658652234626922 0.329584041625474 no 2266 0.255059556058751 3582 24207035 SGTC_922 1866-0035 480 µM -0.660193278482521 0.329075775688435 no 2267 0.254564902557968 3607 3156169 SGTC_3256 9138902 49.47 µM -0.660894881098772 0.32884447820079 no 2268 0.254339864533719 3618 17228773 SGTC_807 1315-0151 48 µM -0.661271393123252 0.328720380414525 no 2269 0.25421914185658 3659 4011080 SGTC_709 3807-1509 243 µM -0.665668122508876 0.327272626060165 no 2270 0.252811626629933 3655 1886677 YPL242C IQG1 SGTC_1742 st038235 28.8875 µM -0.6671813023595 0.326774965444853 no 2271 0.25232816640723 3602 564103 YBR002C RER2 SGTC_1656 st012921 11 µM -0.668168768192507 0.326450369769209 no 2272 0.252012934568336 3569 6732821 SGTC_2598 perillyl alcohol 100 µM -0.668268646044454 0.326417545647638 no 2273 0.251981061821766 3626 10819 An apoptosis inducer. SGTC_1910 st062352 60.4 µM -0.668346513322013 0.326391956071922 no 2274 0.251956214505143 3586 2245730 SGTC_2852 9023854 51.95 µM -0.669296795773594 0.326079729974751 no 2275 0.251653085188803 3687 19798528 SGTC_1641 st009299 47.1 µM -0.669672568843344 0.32595629907907 no 2276 0.251533271011882 3587 4046054 SGTC_211 3455-0679 143.504 µM -0.669800548443211 0.325914265728924 no 2277 0.251492471961238 3646 748649 SGTC_1628 st004252 77.7 µM -0.672206244828589 0.325124556039108 no 2278 0.250726202984221 3612 692968 SGTC_789 1309-1135 70.6 µM -0.672682245636346 0.324968393792059 no 2279 0.250574732560739 3635 3092424 SGTC_3329 9141233 27.5565 µM -0.6732462114344 0.324783412544708 no 2280 0.250395333154304 3625 4909101 YNL103W MET4 SGTC_417 st075190 100 µM -0.674278573470996 0.32444490888916 no 2281 0.250067111794902 3639 222757 SGTC_1790 st045711 43.5 µM -0.675799780446554 0.323946381001381 no 2282 0.24958388706212 3659 585119 SGTC_2196 6573537 42.6665 µM -0.675902633383983 0.323912685557527 no 2283 0.249551232838246 3675 2903087 SGTC_713 1488-1073 324 µM -0.678195343697762 0.323161950342142 no 2284 0.248823922238195 3619 3312542 SGTC_2446 5162541 200 µM -0.678732052730502 0.322986311802747 no 2285 0.248653826562897 3611 1549321 SGTC_2960 9079389 5.97 µM -0.679850321354071 0.322620484151966 no 2286 0.248299620062782 3620 16457355 SGTC_12 0849-0099 9.267 µM -0.680204060679527 0.322504798455526 no 2287 0.248187630772208 3585 6071388 SGTC_1394 3474-0001 65.7 µM -0.680261787273021 0.322485921378855 no 2288 0.248169357837067 3592 5017666 YIL048W NEO1 SGTC_1494 4358-1428 177 µM -0.682093455152245 0.321887188586423 no 2289 0.247589929404703 3676 1564571 SGTC_2463 5473429 200 µM -0.683163000227052 0.321537790921175 no 2290 0.247251924817824 3621 5399405 SGTC_162 k030-0015 37.8 µM -0.683514348876506 0.321423047199787 no 2291 0.247140943195191 3706 1809920 YMR134W ERG29 SGTC_3339 9145883 14.936 µM -0.685405122803907 0.320805849548101 no 2292 0.246544156155534 3582 2030670 SGTC_1236 0330-0013 258 µM -0.685593214018904 0.32074447873715 no 2293 0.246484830969249 3646 4617066 SGTC_1379 2144-0755 36.5 µM -0.685994986337254 0.320613404000397 no 2294 0.24635813500358 3683 5392327 SGTC_929 2805-0021 398 µM -0.68639401549013 0.320483246334439 no 2295 0.246232338632662 3691 3098024 SGTC_908 3448-7491 47.7 µM -0.688441332964659 0.31981578780246 no 2296 0.245587451372236 3685 1203031 SGTC_2860 9025725 38.96 µM -0.690074024795812 0.319283921625014 no 2297 0.245073818529541 3647 40546248 SGTC_792 4534-1957 155 µM -0.691663944307191 0.318766346125639 no 2298 0.244574197381655 3647 1717904 SGTC_3311 9131146 2.8755 µM -0.691922930358266 0.3186820703671 no 2299 0.24449286480861 3666 4900406 YPR165W RHO1 SGTC_1523 st012844 44.7 µM -0.692859388907078 0.31837741889879 no 2300 0.244198898857555 3713 4274103 SGTC_2429 5902844 64.44 µM -0.69346631012375 0.318180039051097 no 2301 0.24400848058593 3698 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1085 doxorubicin 7.67 µM -0.694180486885484 0.317947844207041 no 2302 0.243784514083316 3676 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2890 9046729 58.44 µM -0.695106441027201 0.317646902329688 no 2303 0.243494299269015 3608 903329 SGTC_2007 4011539 71.82 µM -0.695532770600793 0.317508382578609 no 2304 0.243360740782938 3677 45595301 SGTC_1126 isoteolin 1.0172 µM -0.696441767947678 0.317213123426804 no 2305 0.243076106686002 3649 133323 SGTC_2647 atorvastatin 60.16 µM -0.696511471756762 0.317190487139321 no 2306 0.243054287785457 3660 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_358 0075-0058 9.45 µM -0.697546779284892 0.316854351942532 no 2307 0.242730337380448 3666 1069125 SGTC_3307 9126885 69.2785 µM -0.69764770922225 0.316821590914631 no 2308 0.242698768649757 3674 24824909 SGTC_1055 3448-0672 86 µM -0.701365833384785 0.315615721266455 no 2309 0.241537369322388 3655 748378 SGTC_1623 st003709 20.3 µM -0.702739647054766 0.315170658523328 no 2310 0.241109007484473 3675 16192618 SGTC_1206 3978-0017 132 µM -0.703651352536769 0.314875449018011 no 2311 0.240824961399696 3723 3873677 SGTC_2356 9061756 188.97 µM -0.70469764861544 0.314536804903832 no 2312 0.240499207481962 3664 20104043 SGTC_1131 3454-3128 32.3 µM -0.705619672562581 0.3142385119664 no 2313 0.240212343470175 3746 710982 SGTC_2174 5790901 200 µM -0.705927052790985 0.31413909534448 no 2314 0.240116751487307 3704 786020 SGTC_1948 st076329 66.6 µM -0.707206057205861 0.313725569160234 no 2315 0.239719217458404 3597 24208413 SGTC_2117 5521686 200 µM -0.707792016508189 0.313536195594684 no 2316 0.239537212423084 3672 803312 SGTC_3086 9117350 49.47 µM -0.707894676236067 0.313503022513476 no 2317 0.239505333015486 3614 2679265 SGTC_846 0335-0850 148 µM -0.708023005500435 0.313461556795364 no 2318 0.239465485584137 3684 6819598 SGTC_301 4119-0100 24.5 µM -0.71123224248085 0.312425356747472 no 2319 0.238470165818072 3716 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3048 9093155 49.47 µM -0.712633438011657 0.311973402130464 no 2320 0.238036307361614 3648 25236002 SGTC_2755 lomerizine 42.69 µM -0.713946991055225 0.311549973434578 no 2321 0.237629979262924 3698 3949 A calcium channel blocker. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.716086035740282 0.31086097770951 no 2322 0.236969112886402 3723 229346 A bile salt which induces apoptosis. SGTC_3105 9121040 49.47 µM -0.716218936726128 0.310818191554831 no 2323 0.236928085957306 3551 41448907 SGTC_454 lyso-paf C-16 6.67 µM -0.716314546809909 0.31078741241829 no 2324 0.236898573255591 3643 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2430 5571206 200 µM -0.717104323749134 0.310533215286509 no 2325 0.236654864034687 3733 1731771 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.717671180078207 0.310350822995137 no 2326 0.236480028671252 3670 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2415 st077333 57.7 µM -0.717980856528881 0.310251200865405 no 2327 0.236384545270953 3729 2766255 SGTC_281 1672-3440 14.9 µM -0.718310527267933 0.3101451619233 no 2328 0.236282920303955 3724 6833000 SGTC_1728 st035614 33.7865 µM -0.718602108058715 0.310051387807885 no 2329 0.236193057073971 3717 15945546 SGTC_227 fluconazole 33.516 µM -0.719471303374082 0.309771922746667 no 2330 0.235925288676517 3692 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2634 4'-methoxyflavone 100 µM -0.720367411250424 0.309483919780092 no 2331 0.235649404724499 3714 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2163 5671233 125 µM -0.720431574279163 0.309463302705214 no 2332 0.235629657737542 3746 701023 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.721651994413994 0.309071267547906 no 2333 0.23525423178272 3655 756377 SGTC_324 1315-0088 19.6 µM -0.723901606216257 0.30834919526919 no 2334 0.234563071909139 3652 6787421 SGTC_2532 xanthone 78.9 µM -0.727314020528662 0.307255305525916 no 2335 0.233516805592635 3629 7020 An insecticide. SGTC_1567 st069303 68.4 µM -0.727854670673106 0.307082150658685 no 2336 0.233351276931706 3776 5581319 SGTC_590 k048-0076 22.4 µM -0.729589041349213 0.306526971510873 no 2337 0.232820711367338 3711 6832814 SGTC_1 0258-0098 57.368 µM -0.731114307078427 0.306039094330414 no 2338 0.232354668061831 3663 6790032 YDR047W HEM12 SGTC_2280 7785178 200 µM -0.731380732369077 0.305953909799151 no 2339 0.232273315374533 3730 2954328 SGTC_3153 9100258 49.47 µM -0.73187025838247 0.305797420320005 no 2340 0.232123880431754 3684 25236848 SGTC_724 3910-0327 137 µM -0.732741490292255 0.305518996523662 no 2341 0.231858056626332 3754 2885483 SGTC_1907 st060210 83.7 µM -0.733707512436171 0.305210411598199 no 2342 0.231563509467723 3729 688793 SGTC_959 1222-0044 107 µM -0.735220818754141 0.304727281174789 no 2343 0.231102510977391 3689 6083612 SGTC_2941 9056145 11.23 µM -0.735313249941897 0.304697783088098 no 2344 0.231074370272178 3617 2119517 SGTC_996 3970-0799 1.8 µM -0.73658262175502 0.304292809817147 no 2345 0.230688103142609 3790 6615648 YGL040C HEM2 SGTC_1127 asiatic acid 681.4 nM -0.73940203466926 0.303394178773093 no 2346 0.229831453571139 3724 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_503 tyrphostin 8 294 µM -0.740048422216251 0.303188322978475 no 2347 0.22963530664649 3702 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_761 k216-0224 480 µM -0.740053269497071 0.303186779495277 no 2348 0.229633836088768 3763 1340404 SGTC_1383 3049-0032 20.7 µM -0.740076258513804 0.303179459323319 no 2349 0.229626861801715 3766 712864 SGTC_1519 esterone 74 µM -0.741192902772814 0.302823992209531 no 2350 0.229288243025144 3747 698 A steroid. SGTC_2346 9031566 143.75 µM -0.742161552569294 0.302515788182337 no 2351 0.228994729995116 3728 4771086 SGTC_1390 3413-2614 145 µM -0.742404496977675 0.302438510435021 no 2352 0.228921147874756 3783 3421432 SGTC_331 k048-0133 24.5 µM -0.742512782839318 0.302404068833545 no 2353 0.228888354921649 3715 6813582 SGTC_896 0964-0007 44.5 µM -0.742710058056222 0.3023413276349 no 2354 0.228828619486429 3715 6756758 SGTC_3008 9078912 71.4286 µM -0.742847771751949 0.30229753277987 no 2355 0.228786924617681 3734 16648731 SGTC_2050 5263056 171 µM -0.744386659676554 0.301808338925813 no 2356 0.228321293629954 3766 763468 YGL055W OLE1 SGTC_1979 st071809 45.3 µM -0.745765926874812 0.301370189188937 no 2357 0.227904413087639 3845 4976333 SGTC_3123 9126162 49.47 µM -0.746729977831114 0.301064110705061 no 2358 0.227613285214021 3827 25239884 SGTC_215 1287-0124 461.5 µM -0.748067116090427 0.300639812076144 no 2359 0.227209837813247 3778 5560863 SGTC_3292 9120825 59.784 µM -0.750390929040412 0.29990306633137 no 2360 0.226509646268851 3759 24824900 SGTC_2067 5224629 34.075 µM -0.751763049561944 0.299468430911304 no 2361 0.226096783293631 3738 2835000 SGTC_1269 0831-0796 3.05 µM -0.752845658497988 0.299125703389497 no 2362 0.22577133304186 3749 927758 SGTC_794 k038-0031 316 µM -0.753998950525224 0.298760795314846 no 2363 0.225424925959333 3771 6624242 SGTC_2767 sibutramine 71.45 µM -0.754150856408365 0.298712746524222 no 2364 0.225379321380451 3783 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1111 tnp00062 510.699 nM -0.756057123293475 0.298110081151879 no 2365 0.224807473803475 3832 676306 SGTC_2897 9048598 12.99 µM -0.756322963045397 0.298026080071554 no 2366 0.224727791823209 3763 6467404 SGTC_640 3381-0960 37.1 µM -0.759143894872265 0.297135376395366 no 2367 0.223883241861887 3801 1745025 SGTC_1181 1222-0449 220 µM -0.761093674621751 0.296520449501824 no 2368 0.223300559145387 3790 658318 SGTC_3149 9097855 49.47 µM -0.763333107608033 0.295814891353971 no 2369 0.222632381059183 3786 25236625 YMR079W SEC14 SGTC_2226 7298446 200 µM -0.764268867992654 0.295520298314718 no 2370 0.222353516860158 3758 3283010 SGTC_3152 9099253 49.47 µM -0.764610160451794 0.295412887318183 no 2371 0.222251858544807 3750 25236131 SGTC_1300 1094-0077 113 µM -0.764629972659632 0.29540665260457 no 2372 0.222245958040348 3739 5532636 SGTC_942 3253-1115 227 µM -0.767849035415384 0.294394449106424 no 2373 0.221288439268158 3825 46497897 SGTC_1094 duloxetine 25.4 µM -0.769558680838961 0.293857519314527 no 2374 0.220780861529104 3790 60834 A selective serotonin reuptake inhibitor. SGTC_2624 nerol 100 µM -0.769817941151636 0.293776135811199 no 2375 0.220703947826895 3715 637566 A natural product oil. SGTC_2756 carbadox 75.1 µM -0.771909665311751 0.293119911776875 no 2376 0.220083966194075 3807 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2682 pyrogallin 40.03 µM -0.773233176381632 0.292705046080804 no 2377 0.219692197529991 3824 822798 An ATP competetive kinase inhibitor. SGTC_513 4245-1575 41.7 µM -0.774128652709073 0.292424506249101 no 2378 0.219427357453003 3748 719745 SGTC_1377 2944-0135 198 µM -0.77503826005994 0.292139667413922 no 2379 0.219158525973945 3849 1894137 SGTC_312 4092-0653 6.84 µM -0.776197391430864 0.291776878638968 no 2380 0.218816223037486 3782 1148278 SGTC_1371 2421-0008 32.7 µM -0.776475502832876 0.291689865646967 no 2381 0.218734139778468 3782 2827552 SGTC_2838 9002687 71.43 µM -0.776876734397242 0.291564353242292 no 2382 0.218615749419038 3794 6457060 SGTC_2968 9090663 33.37 µM -0.779565228356877 0.290723994714986 no 2383 0.217823414761786 3797 25236811 SGTC_1278 0874-0585 172 µM -0.780357367966472 0.29047660714613 no 2384 0.217590277055226 3858 766306 SGTC_443 clozapine 122 µM -0.781332508624794 0.290172203177894 no 2385 0.217303477439735 3705 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1783 st039459 87.517 µM -0.781375570032737 0.290158764396081 no 2386 0.217290817640125 3921 729761 SGTC_1731 st035964 63 µM -0.781538960948736 0.290107775337891 no 2387 0.217242785550341 3801 6739575 SGTC_1714 st033236 13.627 µM -0.78155120993704 0.290103952991181 no 2388 0.217239184957706 3814 2916566 SGTC_1078 idebenone 36.1 µM -0.78242530441561 0.289831249206003 no 2389 0.216982333712187 3866 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3143 9086658 49.47 µM -0.783754038662124 0.289416935428151 no 2390 0.216592223694793 3891 25236626 SGTC_2146 5545642 200 µM -0.784566529128882 0.289163729227675 no 2391 0.216353880420924 3796 825326 SGTC_3327 9140648 26.9345 µM -0.78459406133953 0.289155150857751 no 2392 0.216345806534443 3814 8029710 SGTC_1643 st009866 20.2 µM -0.785263919447062 0.28894647617818 no 2393 0.216149422792965 3778 3156273 YOR207C RET1 SGTC_2694 st077685 81.9 µM -0.785978732625317 0.288723875245427 no 2394 0.215939973380118 3800 2838096 SGTC_670 4204-0025 119 µM -0.786336294342726 0.288612556778152 no 2395 0.215835247357655 3838 719039 SGTC_3229 9132204 49.47 µM -0.786457214142812 0.28857491580536 no 2396 0.215799837896254 3822 17682924 SGTC_394 menadione 8.33 µM -0.786678779422011 0.288505951029887 no 2397 0.215734964727128 3761 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1675 st018485 24.5 µM -0.786722225866034 0.288492428728674 no 2398 0.215722245158632 3880 3323024 SGTC_426 0988-0037 14.6 µM -0.789545912263688 0.287614223829171 no 2399 0.214896503280081 3778 5383008 SGTC_2846 9008642 19.48 µM -0.791531101071875 0.286997560557276 no 2400 0.214317067321005 3884 2992898 SGTC_558 k064-0027 21.3 µM -0.794801829264737 0.285982935628056 no 2401 0.213364393376917 3871 5088526 SGTC_1088 bifonazole 369 nM -0.795917377328906 0.285637267575343 no 2402 0.213040030104468 3748 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1774 st048371 48.465 µM -0.796098331039603 0.285581215302008 no 2403 0.212987442077435 3801 4242727 SGTC_2887 9044784 58.44 µM -0.797270245571036 0.28521832951629 no 2404 0.212647048489267 3824 6465546 SGTC_2833 9001315 45.46 µM -0.79764533776014 0.285102227871591 no 2405 0.212538166586578 3815 2989378 SGTC_2128 5255449 168.493 µM -0.798877743535827 0.284720922113406 no 2406 0.212180652718415 3829 736008 SGTC_857 0438-0306 1.35 µM -0.799002299137303 0.284682398217568 no 2407 0.21214453942262 3906 4686136 SGTC_1557 sumaresinolic acid 42.3 µM -0.799651598062204 0.284481616368467 no 2408 0.211956341746564 3775 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2473 5854593 8.94 µM -0.802200434684004 0.283694097636687 no 2409 0.211218512492186 3759 2872951 SGTC_1287 0971-0001 34.6 µM -0.802454853667714 0.283615546684484 no 2410 0.211144946776942 3819 4665869 SGTC_2054 5233173 129 µM -0.802561366608842 0.283582664288964 no 2411 0.211114152824423 3867 6889 SGTC_2924 9010168 62.78 µM -0.802771705650281 0.283517734338067 no 2412 0.211053349443549 3934 2993929 SGTC_1993 st073995 70.8 µM -0.804643234362554 0.28294032258447 no 2413 0.210512792797018 3826 3098394 SGTC_291 SEC14.278 35.5 µM -0.80589939584799 0.282553083402035 no 2414 0.210150429820079 3828 1068044 SGTC_3277 9138724 49.47 µM -0.806555915151469 0.282350798436472 no 2415 0.209961190578847 3779 15943418 SGTC_1772 st048439 82.2 µM -0.808609876360657 0.281718387754234 no 2416 0.209369791030504 3891 2927068 YDL195W SEC31 SGTC_2811 7967822 32.47 µM -0.812189032704141 0.280618006930876 no 2417 0.208341585828434 3933 2232244 SGTC_2966 9084041 48.03 µM -0.81308808526474 0.280341928094598 no 2418 0.208083778571399 3797 17741380 SGTC_2021 4019055 173 µM -0.813350002969061 0.280261523801955 no 2419 0.20800870795611 3804 44827708 YER133W GLC7 SGTC_2635 hydroquinidine 100 µM -0.814038807409902 0.280050125853292 no 2420 0.207811359778472 3798 442912 An experimental heart treatment. SGTC_1195 1502-0147 41.1 µM -0.816321512270637 0.279350103943443 no 2421 0.207158136884985 3843 817940 SGTC_2705 st078069 42.8 µM -0.818178052536725 0.27878139866206 no 2422 0.206627762693919 3904 1530061 SGTC_1851 st056236 18.9 µM -0.818999642711294 0.278529904786988 no 2423 0.206393308717402 3827 5393171 SGTC_405 ebelactone b 50 µM -0.819583630543093 0.27835120969236 no 2424 0.206226754278584 3828 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_208 k072-0098 12.366 µM -0.819872006749344 0.278262989745906 no 2425 0.206144538230371 3835 5948901 SGTC_1854 st056233 32.9 µM -0.821924551767987 0.277635470006766 no 2426 0.205559919324641 3767 5393174 SGTC_677 0929-0063 136 µM -0.823929737990071 0.277023097509765 no 2427 0.204989741044501 3836 1539583 SGTC_2714 st079313 56.9 µM -0.824730891414564 0.276778614780329 no 2428 0.204762194753579 3841 2939799 SGTC_2539 epi(13)torulosol 80 µM -0.82476834760987 0.276767187106012 no 2429 0.204751559996313 3896 6708597 SGTC_2380 9035439 200 µM -0.825128970739919 0.276657174846443 no 2430 0.204649186815532 3987 6462575 SGTC_326 k292-0812 17.5 µM -0.825567209744381 0.276523513817134 no 2431 0.20452482114734 3823 3579357 SGTC_2038 4100038 30.985 µM -0.825791805815978 0.276455025244686 no 2432 0.204461101580138 3880 3596803 SGTC_811 0416-0114 265 µM -0.825960629513071 0.276403549438213 no 2433 0.204413212827822 3938 6612453 SGTC_1356 1502-0781 85.8 µM -0.826174510718535 0.276338341958487 no 2434 0.204352552591553 3828 567702 SGTC_1243 0416-0003 5.65 µM -0.826907201117622 0.27611501866375 no 2435 0.204144830766706 3877 2141977 SGTC_3204 9114183 49.47 µM -0.82744485155514 0.275951199732961 no 2436 0.20399248389398 3883 17027248 SGTC_858 0438-0351 2.77 µM -0.827680170303224 0.275879514514906 no 2437 0.203925826059837 3869 2799119 SGTC_3228 9131799 49.47 µM -0.829248352770585 0.27540203239869 no 2438 0.20348194462773 3885 17015818 SGTC_616 4092-0450 108 µM -0.831759623550693 0.274638245547652 no 2439 0.202772319288882 3906 787165 SGTC_1226 3909-7979 35.4 µM -0.832191947752953 0.274506862410783 no 2440 0.202650304118375 3902 6615510 SGTC_2702 st077768 96.8 µM -0.83413890779546 0.273915566701147 no 2441 0.20210135619156 3861 6484119 SGTC_926 2268-1401 59.4 µM -0.835937216346971 0.273369976688492 no 2442 0.20159511209768 3852 2931578 SGTC_1433 4060-0023 7.6 µM -0.839407136019237 0.272318758776848 no 2443 0.200620440390966 3887 3840627 SGTC_2588 indole-3-carbinol 100 µM -0.839672216372292 0.272238534893697 no 2444 0.200546098021994 3937 3712 Induces cell cycle arrest. SGTC_2550 chrysin dimethyl ether 71.87 µM -0.839681810117792 0.272235631664059 no 2445 0.200543407745164 3689 88881 An O-methylated flavonoid and antioxidant. SGTC_2528 xanthyletin 44.79 µM -0.841244488212607 0.271762944308724 no 2446 0.200105491075589 3937 65188 An natural product with antifungal activity of unknown mechanism. SGTC_154 3389-1638 511.116 µM -0.841754286120357 0.27160882628165 no 2447 0.19996275243894 3888 5238686 SGTC_1392 3455-1037 33.9 µM -0.842358256696283 0.271426295064648 no 2448 0.199793725591709 3897 981132 SGTC_1156 4092-0367 4.88 µM -0.843153583138474 0.271186025784491 no 2449 0.199571277153056 3901 1357585 SGTC_2397 5161689 200 µM -0.843711945939431 0.271017406946933 no 2450 0.199415195235662 3907 2259942 SGTC_1186 1319-0216 26 µM -0.845535025809899 0.270467223210109 no 2451 0.198906092620854 3960 4565136 SGTC_2316 5844804 197.44 µM -0.845925532256678 0.270349445646477 no 2452 0.198797144033999 3949 776813 SGTC_2036 5160441 105 µM -0.846304428646744 0.270235194210788 no 2453 0.198691468967514 3882 134534 YIL048W NEO1 SGTC_877 0771-0151 33.1 µM -0.846533729049941 0.270166063290363 no 2454 0.198627533018479 3939 6166523 SGTC_2504 purpurogallin 52.29 µM -0.847604752362814 0.269843281669516 no 2455 0.19832906340161 3822 5281571 An antioxidant. SGTC_1583 clindamycin 39.6 µM -0.847999186196247 0.269724457112135 no 2456 0.198219211975726 3871 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2898 9056270 58.44 µM -0.849115921608297 0.269388178896751 no 2457 0.197908395885225 3850 19154699 SGTC_850 0388-0143 75.9 µM -0.850540021843448 0.268959650257259 no 2458 0.19751245966751 3856 67273 SGTC_722 3534-0461 190 µM -0.851845778794114 0.268567033482423 no 2459 0.197149847098651 3951 658262 SGTC_1393 3470-5649 58.2 µM -0.852136949711838 0.268479523111429 no 2460 0.197069043034406 3879 4108395 SGTC_29 0299-0004 12.984 µM -0.852561359895565 0.268351993840879 no 2461 0.19695129908742 3790 16871 A napthoquinone isolated from Swertia calycina. SGTC_784 4579-0127 173 µM -0.854465923895446 0.267780074636265 no 2462 0.19642344122515 4002 1948547 SGTC_3033 9090887 49.47 µM -0.854745105182723 0.267696291264767 no 2463 0.196346137084574 3938 19325384 SGTC_2218 6965428 192.983 µM -0.856488468596651 0.267173400244027 no 2464 0.195863824262133 3818 675684 SGTC_1827 berberine 7.24 µM -0.857804392789359 0.266779053783499 no 2465 0.195500241863792 3857 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2 0422-0095 29 µM -0.85847701815745 0.266577600035911 no 2466 0.195314557689711 3778 6790840 SGTC_2636 apigenin dimethyl ether 100 µM -0.859351736319965 0.266315733877177 no 2467 0.195073244353517 3937 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1089 terbinafine 2.25 µM -0.86302581123509 0.265217242228637 no 2468 0.194061637868299 3929 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_5 0352-0601 109.883 µM -0.863726928792169 0.265007880618305 no 2469 0.193868958470662 3842 762456 SGTC_1915 st067105 30.6 µM -0.865777481156274 0.264396044855798 no 2470 0.193306100279138 3892 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2963 9082507 9 µM -0.866026493157281 0.264321794621635 no 2471 0.193237816691977 3980 16459611 SGTC_2327 6189656 200 µM -0.86788878525945 0.263766834379113 no 2472 0.192727609461305 4011 5349088 SGTC_2432 5630864 12.22 µM -0.868240010688892 0.263662236370203 no 2473 0.192631477501158 3969 5714970 SGTC_974 1326-0144 138 µM -0.86824674208932 0.263660231906875 no 2474 0.192629635373212 3964 5411856 SGTC_56 0957-0365 83.25 µM -0.870252725577759 0.263063240583847 no 2475 0.192081153838912 3937 6752360 SGTC_2950 9072895 21.46 µM -0.871410083176028 0.262719119348129 no 2476 0.191765141095817 3890 17332245 SGTC_2789 5281112 71.43 µM -0.871591468421529 0.26266520831146 no 2477 0.191715643313698 3973 765948 SGTC_1003 4049-0218 100 µM -0.871899856917999 0.262573562563073 no 2478 0.191631505881796 3968 295161 SGTC_874 0599-0792 117 µM -0.874951321569127 0.26166762255498 no 2479 0.19080019634498 3921 765305 SGTC_2091 4-phenylthiadiazole 200 µM -0.87567660688536 0.261452530986502 no 2480 0.190602933059542 3910 270010 SGTC_3223 9129970 49.47 µM -0.876783394763177 0.261124475583321 no 2481 0.190302150008818 3959 17248386 SGTC_1128 3448-9350 235 µM -0.876914260895099 0.261085700442288 no 2482 0.190266604833196 3997 619386 SGTC_642 0335-0876 158 µM -0.877787791976515 0.260826952315881 no 2483 0.190029445369082 3971 6812350 SGTC_1836 st055642 81 µM -0.878729609698856 0.260548124906311 no 2484 0.189773950062305 3951 8571 SGTC_2738 aclarubicin 5.55 µM -0.878880897405071 0.260503350125638 no 2485 0.189732928596214 3880 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2912 7964298 10.93 µM -0.879994870159317 0.260173783207567 no 2486 0.18943104426887 3992 2975850 SGTC_843 0310-0051 143 µM -0.880352948408443 0.260067892034836 no 2487 0.189334068615987 3974 2065037 SGTC_1013 4112-3890 241 µM -0.881188832100943 0.259820790378281 no 2488 0.189107811449014 3904 705171 SGTC_99 0109-0120 622.8 µM -0.881479230178426 0.259734972052437 no 2489 0.189029245428932 3922 759414 SGTC_1227 3909-8010 46.6 µM -0.882779668129092 0.259350846652169 no 2490 0.188677663896355 3940 15982272 SGTC_3267 9137951 49.47 µM -0.883979734564604 0.258996629730127 no 2491 0.188353576311655 3970 16643986 SGTC_2464 5717415 7.67 µM -0.884263415215098 0.258912933872607 no 2492 0.188277016282968 3939 5285744 SGTC_2836 9010338 19.48 µM -0.884799729539634 0.258754740356996 no 2493 0.188132327685624 3957 2994051 SGTC_1797 st048695 56.8 µM -0.884991737370384 0.258698117087589 no 2494 0.188080543883851 3930 592262 YIL048W NEO1 SGTC_1747 st037496 66.6 µM -0.887117191484472 0.25807174764923 no 2495 0.1875079046388 3955 723305 SGTC_757 1066-0008 322 µM -0.887270895323584 0.25802648177801 no 2496 0.187466535611853 3984 6842497 SGTC_1757 st041620 31.8375 µM -0.888650395085596 0.257620402695321 no 2497 0.187095499046206 4035 5289815 SGTC_3338 9144300 39.5675 µM -0.890545170171498 0.257063185032075 no 2498 0.186586612675964 3979 4901274 SGTC_3197 9113331 49.47 µM -0.890801810129335 0.256987760285389 no 2499 0.186517751950473 3975 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2656 pseudo-anisatin 100 µM -0.891168358605995 0.256880054136226 no 2500 0.186419428256337 3981 6708809 A neurotoxin. SGTC_3205 9113483 49.47 µM -0.892530963217303 0.256479874153913 no 2501 0.186054202072039 4030 17018033 SGTC_486 niguldipine 82 µM -0.892783254109323 0.256405815116321 no 2502 0.18598662789831 3996 1236 A calcium channel blocker. SGTC_131 0141-0277 33.849 µM -0.894201362009772 0.255989742350588 no 2503 0.185607081824827 3943 1547771 SGTC_1309 pyrazolanthrone 13.4 µM -0.897068742740831 0.255149530450445 no 2504 0.184841118277484 3962 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3347 9188721 44.724 µM -0.897843578701901 0.254922732547084 no 2505 0.184634473963468 3997 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_68 0986-0284 82.829 µM -0.898986067956541 0.254588513464046 no 2506 0.184330040797121 4063 423278 YIL048W NEO1 SGTC_3054 9094397 49.47 µM -0.899523883569942 0.254431262599298 no 2507 0.184186840048235 3994 2598354 SGTC_1208 2323-2347 50.3 µM -0.900427271125757 0.254167237463879 no 2508 0.183946456662653 3984 5412760 SGTC_1170 0310-0127 64.8 µM -0.901145451471337 0.253957443776122 no 2509 0.183755494722193 3991 774975 SGTC_2273 7815444 169.05 µM -0.90189008825331 0.253740017667905 no 2510 0.183557628555512 3915 2824616 SGTC_2612 dictamnine 15.46 µM -0.904023147608657 0.253117728206671 no 2511 0.182991563704101 3955 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_894 0960-0238 55.9 µM -0.904476604275811 0.252985542273148 no 2512 0.182871367281558 3944 6741907 YDL195W SEC31 SGTC_1966 st070145 16.1 µM -0.905041719283596 0.252820857973573 no 2513 0.182721642898446 3925 3748532 SGTC_2329 6138490 200 µM -0.907050862121537 0.252235816272419 no 2514 0.182189950588352 4117 720019 SGTC_11 0438-0307 1.3 µM -0.907725613947206 0.252039495748302 no 2515 0.182011603833941 3955 4011476 SGTC_2245 6637752 200 µM -0.909564836476501 0.251504779556075 no 2516 0.181526025028605 4055 681890 SGTC_2458 5808907 16.39 µM -0.910869536915181 0.251125828438957 no 2517 0.181182059124786 4120 2731747 SGTC_1032 k061-1018 98.7 µM -0.912084121976461 0.250773323036965 no 2518 0.180862218048705 4101 4005393 SGTC_1353 1498-1206 8.11 µM -0.912961226341803 0.250518926659373 no 2519 0.180631467180948 4022 6756808 SGTC_978 1416-0512 87.4 µM -0.913153534550566 0.250463167644299 no 2520 0.180580898930619 4054 6814003 SGTC_2896 9052656 71.43 µM -0.914752946653092 0.249999679274407 no 2521 0.180160670859224 3871 6469436 SGTC_480 am 92016 50 µM -0.914785563591821 0.249990232056668 no 2522 0.180152107506233 3952 2129 K+ channel blocker. SGTC_1262 0737-0114 49.6 µM -0.916237209446014 0.249569967138294 no 2523 0.179771246625227 4066 765919 SGTC_1018 4259-0013 28.1 µM -0.916264460270344 0.249562081363108 no 2524 0.17976410180649 4067 6801262 SGTC_1350 1495-0454 146 µM -0.916483608373462 0.249498669647961 no 2525 0.179706650453642 4041 1069057 SGTC_4 0960-0234 25.671 µM -0.918934891144309 0.248789961298363 no 2526 0.179064814311892 3990 6821112 SGTC_1996 st072960 66.8 µM -0.919299056732974 0.248684766231288 no 2527 0.178969585538451 4023 1719405 SGTC_1909 st060837 51.5 µM -0.920386690920047 0.248370726742908 no 2528 0.178685360546781 3999 678937 SGTC_1066 ketoconazole 628 nM -0.92116272022568 0.248146788186057 no 2529 0.17848273924705 4055 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2649 anisomycin 9.56 µM -0.921550257383928 0.248034997029702 no 2530 0.1783816074778 3983 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1799 st045822 46.1415 µM -0.923484334898007 0.2474774840203 no 2531 0.177877430114429 3955 3674992 SGTC_569 4130-2812 160 µM -0.924289403385007 0.247245614246929 no 2532 0.177667829194759 3811 743552 SGTC_824 1304-0008 100 µM -0.924371341257204 0.247222021631594 no 2533 0.177646505274657 4026 768245 SGTC_1941 st076221 61.8 µM -0.926689059169373 0.24655517312187 no 2534 0.177043999842742 3925 2828568 SGTC_112 phenothiazine 287.218 µM -0.93543803525517 0.244046645669559 no 2535 0.174781301512549 3923 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1782 st039423 80.636 µM -0.938222972867501 0.243251039845025 no 2536 0.174064917408434 4046 2068169 SGTC_3354 9151612 71.43 µM -0.940063874996674 0.242725898406686 no 2537 0.173592398727359 4049 27261949 SGTC_2045 5106652 78.05 µM -0.940073498873393 0.242723154683276 no 2538 0.173589930638604 3977 673349 SGTC_1496 4469-0713 57.4 µM -0.940144798394654 0.242702828037526 no 2539 0.173571646234275 3982 746691 SGTC_2123 5259487 200 µM -0.940849834042723 0.242501880374479 no 2540 0.173390909361918 4043 2173474 SGTC_1780 st038448 24.544 µM -0.945090092927623 0.241295234405789 no 2541 0.172306441374129 4091 728868 YDL195W SEC31 SGTC_1139 k015-0024 46.9 µM -0.945453613190556 0.241191939888833 no 2542 0.172213671025699 4053 2766652 SGTC_268 camptothecin 39.6153 µM -0.946301298478506 0.240951162966581 no 2543 0.171997465637514 3986 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_934 2950-0684 338 µM -0.947362867842191 0.240649818777978 no 2544 0.171726952790954 4081 1121253 SGTC_2988 9073640 71.4286 µM -0.952428802322458 0.23921459815532 no 2545 0.170439779030074 4107 9102229 SGTC_2913 7966556 36.57 µM -0.952786320293818 0.239113487380545 no 2546 0.170349173385452 3897 2976516 SGTC_675 1309-0189 238 µM -0.953106552437427 0.239022941362433 no 2547 0.170268043272985 4062 4246530 SGTC_529 4076-0302 30.3 µM -0.955108192320503 0.238457400298181 no 2548 0.169761493251496 3987 5816522 SGTC_626 0214-0009 33 µM -0.955984545929443 0.238210027130251 no 2549 0.169540021133176 4107 3437874 SGTC_3219 9131112 49.47 µM -0.955999213943662 0.238205887905609 no 2550 0.169536315810122 3974 17612988 YMR079W SEC14 SGTC_1879 gemcitabine 100 µM -0.95919729752857 0.237304349676567 no 2551 0.16872968082796 4004 60750 A nucleoside analog which inhibits DNA replication. SGTC_1067 clotrimazole 1.36 µM -0.959584032215116 0.237195456495603 no 2552 0.168632304305819 4065 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1690 st023502 41.2 µM -0.960926945629653 0.23681754457517 no 2553 0.168294450632792 4046 24207482 SGTC_2223 6903751 107.57 µM -0.961234331513689 0.236731089094387 no 2554 0.168217178963961 4007 5598863 SGTC_292 k038-0015 474 µM -0.962577946812493 0.236353387157376 no 2555 0.167879684537835 4042 46368540 SGTC_213 1246-0773 967 nM -0.963072605535773 0.236214417892433 no 2556 0.167755544124979 4030 6251622 SGTC_1607 st000305 50.6 µM -0.963231632672087 0.236169750420379 no 2557 0.167715646957904 4065 5457690 SGTC_2277 7947813 106.88 µM -0.964112131391073 0.235922520539587 no 2558 0.167494855596526 4124 1246798 SGTC_2977 9011197 71.43 µM -0.968168333909943 0.234785448333127 no 2559 0.166480153425054 4143 2704722 SGTC_714 4296-0578 26.1 µM -0.968773686666209 0.234616010436081 no 2560 0.166329059030154 4083 1589775 SGTC_70 0141-0289 43.283 µM -0.970373525343618 0.234168542184212 no 2561 0.165930170083805 4051 352408 SGTC_1396 3511-0007 98.6 µM -0.971183171309106 0.2339422677679 no 2562 0.165728536272506 4058 X1396 SGTC_1945 st075991 56.6 µM -0.971559585811993 0.233837111234317 no 2563 0.165634848168169 4077 1084980 SGTC_2098 5376439 882.5 nM -0.972301703214985 0.233629867349801 no 2564 0.16545023838221 4095 2844116 SGTC_2018 5133068 143 µM -0.976078371091733 0.232576773622471 no 2565 0.164512814363329 4023 785362 SGTC_2571 chrysanthemic acid 100 µM -0.978382017739585 0.231935718186407 no 2566 0.163942709294108 4089 2743 An insecticide. SGTC_415 dibenzyl ketone 100 µM -0.980572699257695 0.231327012411555 no 2567 0.163401751381296 4061 7593 SGTC_1837 st055472 66.5 µM -0.982725236234507 0.230729774420514 no 2568 0.16287134337874 4169 676091 SGTC_2484 5809818 12.04 µM -0.98431757227481 0.230288523335288 no 2569 0.162479696070174 4032 2870548 SGTC_973 1325-0077 65.9 µM -0.985356851574015 0.230000784107405 no 2570 0.162224408134199 4083 2835149 SGTC_2865 9030313 51.95 µM -0.985890963588941 0.22985298592225 no 2571 0.162093310832886 4021 42562754 SGTC_2805 7950783 58.44 µM -0.987429982092159 0.229427409927176 no 2572 0.161715946101698 4088 1178958 YDL195W SEC31 SGTC_1044 1222-0021 1.78 µM -0.987585072679248 0.229384548120573 no 2573 0.16167794993465 4034 4306703 SGTC_2141 5621638 7.665 µM -0.988511595975356 0.229128581857404 no 2574 0.161451079087545 4103 2856238 SGTC_985 1493-0307 8.71 µM -0.989559343148566 0.228839318755182 no 2575 0.161194775283707 4085 3278274 SGTC_1596 piperlongumine 63 µM -0.989622637857135 0.228821850855557 no 2576 0.161179300404152 4124 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1175 0741-0056 27.6 µM -0.989976488845744 0.228724209821997 no 2577 0.161092805476941 4171 765927 SGTC_809 3998-0021 90 µM -0.990179099296284 0.228668312376201 no 2578 0.161043293251374 4024 715485 SGTC_2697 mebhydrolin 72.4 µM -0.990210061656911 0.228659770961104 no 2579 0.161035727806846 4162 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2242 6630449 61.2675 µM -0.992676571520364 0.227979924406268 no 2580 0.160433797928661 4139 691249 YDR170C SEC7 SGTC_2103 5378138 10 µM -0.993896638462448 0.227644056916245 no 2581 0.160136595545084 4148 244142 SGTC_1176 0848-0131 83.3 µM -0.994665594190865 0.227432517275134 no 2582 0.159949466699223 4118 6769040 SGTC_3227 9130768 49.47 µM -0.99746876702918 0.22666230300806 no 2583 0.159268513376701 4133 17720899 SGTC_3281 9140613 49.47 µM -1.00141804327071 0.225579681629365 no 2584 0.15831237225678 4095 16013766 SGTC_1715 st032160 10.2275 µM -1.00167525146863 0.225509274380885 no 2585 0.158250231661168 4035 5289825 SGTC_2909 7941780 10.49 µM -1.00240441607422 0.225309743106942 no 2586 0.158074155073851 4057 1243215 SGTC_2955 9076254 12.21 µM -1.00265351112092 0.225241602743182 no 2587 0.158014033794617 4021 16459619 SGTC_3279 9140807 49.47 µM -1.00455805210687 0.224720998337796 no 2588 0.157554852324476 4132 45595718 SGTC_2016 5121758 140 µM -1.00529503205983 0.22451972886137 no 2589 0.157377403282457 4023 2795203 SGTC_1238 0333-0287 48.8 µM -1.00585873044481 0.224365851701572 no 2590 0.157241765446211 4062 7226 SGTC_2278 7948257 134.34 µM -1.0092023042774 0.223454361720676 no 2591 0.156438810885203 4097 1247028 SGTC_3055 9094636 49.47 µM -1.01010922219042 0.223207490968528 no 2592 0.156221482168792 4124 25236176 SGTC_1092 toremifene 6.32 µM -1.01111381187848 0.222934214458938 no 2593 0.155980980238649 4081 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_647 0140-0236 81 µM -1.01177783074367 0.222753687414713 no 2594 0.155822146068489 4105 990837 SGTC_935 2996-0153 430 µM -1.0119325104348 0.222711646559068 no 2595 0.155785161805647 4135 23738523 SGTC_1219 1469-0211 33.1 µM -1.01199083652183 0.222695795111705 no 2596 0.155771217409638 4116 6822282 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.01239952520924 0.222584742659797 no 2597 0.155673532642169 4132 4174840 SGTC_534 k292-0788 63.4 µM -1.0125767275078 0.222536601521251 no 2598 0.155631190308842 4147 4146317 SGTC_2594 a-mangostin 100 µM -1.01451459800217 0.222010521411725 no 2599 0.155168633660819 4146 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3332 9141069 11.198 µM -1.01460841808352 0.221985069797119 no 2600 0.155146262495658 4036 17332883 SGTC_1061 3448-9325 110 µM -1.01578522861919 0.221665964881045 no 2601 0.154865835817024 4017 723482 SGTC_1642 st009582 77.7 µM -1.01608184227855 0.221585576254922 no 2602 0.154795207477442 4099 6739311 SGTC_73 0327-0325 16.231 µM -1.01676215004356 0.221401261291865 no 2603 0.154633295972257 3979 53298 SGTC_2969 9091408 28.7 µM -1.01783511087456 0.221110743539047 no 2604 0.154378161574979 4053 4286311 SGTC_2342 7990637 118.86 µM -1.01916543074817 0.220750845623732 no 2605 0.154062217642968 4168 2033102 YER133W GLC7 SGTC_3102 9121669 49.47 µM -1.01987858511472 0.220558050710185 no 2606 0.153893023504294 4139 41905072 SGTC_1157 4092-0394 27.6 µM -1.02042993237275 0.220409065051099 no 2607 0.153762302024094 4204 3659885 SGTC_226 1,3-diallylurea 8.28947 mM -1.02107961331347 0.220233581612255 no 2608 0.153608360518518 4058 74537 YKL182W FAS1 SGTC_1087 pterostilbene 9.05 µM -1.02138098676503 0.220152205710757 no 2609 0.153536984923626 4163 5281727 Similar to reservatol, lowers cholesterol. SGTC_1569 carminic acid 40.6 µM -1.02739002181854 0.218533268871827 no 2610 0.152118424048906 4214 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2837 9008476 45.46 µM -1.02846387340339 0.218244678562029 no 2611 0.151865838085204 4151 2992805 SGTC_2126 5251174 33.877 µM -1.03090152667637 0.217590391460988 no 2612 0.151293500310422 4145 790722 SGTC_849 0386-0493 241 µM -1.03192098242902 0.217317096828306 no 2613 0.151054567814166 4090 726119 SGTC_834 0312-0008 75.7 µM -1.03230114866136 0.217215233027842 no 2614 0.150965531576473 4119 6385573 YIL048W NEO1 SGTC_1152 3909-8331 15.9 µM -1.03236079528336 0.217199253492145 no 2615 0.150951565303279 4078 16001939 SGTC_2724 maprotiline 69.64 µM -1.03256498402704 0.217144555765169 no 2616 0.150903760962921 4048 4011 A tricyclic antidepressant. SGTC_522 1273-0010 11.6 µM -1.03348412781112 0.216898435678914 no 2617 0.150688697283029 4215 5705015 SGTC_1234 0326-0494 15.5 µM -1.03436691087167 0.21666220382988 no 2618 0.15048233362036 4206 1547813 SGTC_2743 auranofin 4.32 µM -1.03610411103302 0.216197765656789 no 2619 0.150076787263293 4102 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1659 st012954 42.1 µM -1.03669178139495 0.216040783348571 no 2620 0.149939761727906 4102 24207262 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.03717492586811 0.215911772142126 no 2621 0.14982717072574 4148 7104 SGTC_2051 5263410 176 µM -1.0391138005226 0.215394495163938 no 2622 0.14937590668323 4131 227584 SGTC_376 3970-0862 59.1 µM -1.04169862713449 0.214706002539625 no 2623 0.148775712852148 4181 3135186 SGTC_650 1328-0195 38 µM -1.04493372689509 0.213846108118342 no 2624 0.148026800297571 4127 2780821 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.04527480997359 0.213755564727567 no 2625 0.147947988233627 4177 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2413 inermin 26.06 µM -1.04606537310854 0.213545788923273 no 2626 0.147765425470832 4232 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_694 1315-0438 43.2 µM -1.04775527775216 0.213097775500514 no 2627 0.147375686096065 4122 6793154 SGTC_3018 9082602 49.47 µM -1.05028852506087 0.212427210124129 no 2628 0.146792739664057 4095 17332089 SGTC_2350 9023895 38.85 µM -1.05047382392035 0.212378208867883 no 2629 0.146750159813942 4171 2997209 SGTC_2597 laccaic acid a 100 µM -1.05055142034099 0.212357690886791 no 2630 0.146732331383793 4155 5491415 A textile dye. SGTC_1928 4'-methoxychalcone 40.3 µM -1.05162801428573 0.212073138355246 no 2631 0.146485124825235 4187 641818 SGTC_1451 4152-0210 104 µM -1.05166916888388 0.21206226528665 no 2632 0.146475680493465 4182 659563 SGTC_107 0358-0022 2.6945 µM -1.05294380453296 0.211725667243978 no 2633 0.146183374067973 4181 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3230 9131665 49.47 µM -1.05534304593615 0.211092939000441 no 2634 0.145634230345203 4109 15943720 SGTC_620 0109-0052 432 µM -1.05632221677772 0.210835030716455 no 2635 0.145410514581925 4149 493037 SGTC_1855 st056195 39.6 µM -1.05666150133294 0.210745708134324 no 2636 0.145333050598802 4104 4028379 SGTC_1687 st020778 55.3625 µM -1.0576640187903 0.210481907643345 no 2637 0.145104322377101 4166 4259299 SGTC_178 4092-0806 87.505 µM -1.05901423865248 0.210126919894901 no 2638 0.144796647589947 4037 2169044 SGTC_3264 9137442 49.47 µM -1.0618248041346 0.209389120091936 no 2639 0.144157613559743 4153 17015726 SGTC_2052 5265182 7.135 µM -1.06293817756347 0.20909727118744 no 2640 0.143904994144646 4165 1239884 SGTC_478 N-arachidonylglycine 10 µM -1.06480278555984 0.208609037793077 no 2641 0.143482592170722 4113 5283389 SGTC_1501 4491-0275 38.4 µM -1.06488066959752 0.208588659083912 no 2642 0.143464966814874 4135 5104718 SGTC_80 0159-0065 512.242 µM -1.066559782836 0.208149597017501 no 2643 0.143085334655876 4041 1548079 SGTC_150 3970-0969 77.2 µM -1.0665816519153 0.208143882192822 no 2644 0.14308039473826 4245 6615640 SGTC_1412 3909-8563 178 µM -1.06675909473056 0.208097516285485 no 2645 0.143040317160743 4237 23767530 SGTC_633 0437-0093 97.7 µM -1.06744961229919 0.207917141685114 no 2646 0.14288442772125 4085 2831118 SGTC_2541 muurolladie-3-one 83.07 µM -1.06799821379946 0.20777390373549 no 2647 0.142760658760917 4159 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1648 st011736 69.8 µM -1.07099701429765 0.206991958023042 no 2648 0.142085386066367 4156 2855514 SGTC_1388 3346-4487 254 µM -1.07113136595621 0.206956966251643 no 2649 0.142055183318859 4222 3345614 SGTC_144 4161-2749 112.381 µM -1.07158531970189 0.206838760296464 no 2650 0.141953164996331 4115 797501 YMR168C CEP3 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.07397925423707 0.206216060125898 no 2651 0.141415989889107 4161 390807 SGTC_1594 piperine 70.1 µM -1.07404715537315 0.20619841419082 no 2652 0.141400773667787 4141 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_453 enantio-paf c16 10 µM -1.07540701701978 0.205845206105423 no 2653 0.141096270781167 3961 13871343 A lipid and platelet activating factor SGTC_200 k038-0079 37.545 µM -1.07544023800667 0.205836581838578 no 2654 0.141088837441149 4134 3436683 SGTC_2747 doxorubicin 7.63 µM -1.07705745322197 0.205417007256215 no 2655 0.140727299626362 4151 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3333 9141820 12.094 µM -1.07790531911713 0.20519723779012 no 2656 0.140538005716913 4163 1939433 SGTC_751 0833-0568 350 µM -1.07825653137779 0.205106243420997 no 2657 0.140459644979872 4191 6954252 SGTC_217 ketoconazole 989 nM -1.07869979887256 0.204991433019454 no 2658 0.140360787688856 4013 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1344 1488-0097 29.1 µM -1.07888130288653 0.20494443281916 no 2659 0.140320322393187 4203 747966 SGTC_2139 5578692 56.4705 µM -1.07897051580647 0.204921333611969 no 2660 0.140300435780433 4129 650991 YMR113W FOL3 SGTC_1267 0828-0272 9.49 µM -1.08011153613526 0.204626034624057 no 2661 0.140046257673742 4251 745334 SGTC_2190 6049624 200 µM -1.08104025803233 0.204385866019137 no 2662 0.139839603099724 4052 2265554 SGTC_3244 9134489 49.47 µM -1.08329657287259 0.203803079767992 no 2663 0.139338402999436 4182 16584271 SGTC_353 1988-1175 58.3 µM -1.0840684157468 0.203603947153542 no 2664 0.139167232763105 4024 2788357 SGTC_2318 6029776 164 µM -1.08434817266661 0.203531799559493 no 2665 0.139105226912987 4243 818325 SGTC_44 0929-0055 61.211 µM -1.08482854936627 0.203407948932594 no 2666 0.138998799189811 4078 1379590 SGTC_257 daunorubicin 18.5 µM -1.08634045073088 0.203018444378094 no 2667 0.138664198466595 4199 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.0872470461383 0.202785095916978 no 2668 0.138463822102232 4034 4000243 SGTC_1619 st003326 88.7 µM -1.08874848331614 0.202398993855842 no 2669 0.138132407567377 4183 2849032 SGTC_1465 k213-0056 144 µM -1.08929778369111 0.202257848430277 no 2670 0.138011294905842 4057 24048857 YMR208W ERG12 SGTC_1688 st021091 57.6 µM -1.08994535437616 0.202091527609447 no 2671 0.137868608131029 4203 3656366 SGTC_52 0329-0193 875 nM -1.09032596862818 0.201993809570436 no 2672 0.137784789946087 4263 3739292 SGTC_1672 st016598 6.51 µM -1.09222150925422 0.201507574066879 no 2673 0.137367875232822 4193 4665860 YNL267W PIK1 SGTC_160 3453-0671 289.699 µM -1.09379757113204 0.20110382429257 no 2674 0.137021884811134 4226 5322268 SGTC_191 3914-0123 66.505 µM -1.09396911498477 0.201059908112142 no 2675 0.136984262019851 4190 3144412 SGTC_34 0469-0683 81.75 µM -1.09674750934354 0.200349425057731 no 2676 0.136375890902528 4150 3690923 SGTC_1952 st077036 64.1 µM -1.09763790025406 0.200122056363281 no 2677 0.136181318148582 4215 2937007 SGTC_1606 st000094 49.2 µM -1.09814701048329 0.199992120571839 no 2678 0.136070150200819 4228 1242210 SGTC_2495 cafestol 54.53 µM -1.09953784898461 0.199637407579109 no 2679 0.135766767143259 4199 16667697 An anti-infammatory. SGTC_469 w7 172 µM -1.10035637381175 0.199428831876058 no 2680 0.135588439352559 4270 45115570 A P450 inhibitor. SGTC_2106 5357045 167.29 µM -1.10162665661446 0.199105399537979 no 2681 0.135312007270375 4211 668842 SGTC_1410 3909-8106 77.9 µM -1.10211918526553 0.19898007969887 no 2682 0.135204929849147 4249 1039210 SGTC_623 k072-0108 16.9 µM -1.10329330867015 0.198681525495817 no 2683 0.134949905747953 4159 5382803 SGTC_646 4092-0839 27.3 µM -1.10662480004128 0.197835871084495 no 2684 0.134228090183778 4232 877796 SGTC_527 4476-4215 268 µM -1.10733496683921 0.197655886353899 no 2685 0.134074565845582 4183 4418754 SGTC_111 0083-0039 52.457 µM -1.11054100539635 0.196844580338371 no 2686 0.133382984212502 4079 759313 SGTC_1420 4'-methoxyflavone 42 µM -1.1106782330669 0.196809899167839 no 2687 0.133353437396777 4192 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1529 apigenin 74 µM -1.11108182724288 0.196707921370955 no 2688 0.133266564672699 4232 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.11304198480112 0.196213095656636 no 2689 0.132845199100619 4310 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_373 0844-0104 25.9 µM -1.11315493032545 0.19618460650086 no 2690 0.132820947733406 4220 5375804 SGTC_2657 nystatin 74.44 µM -1.11354161021175 0.196087090126035 no 2691 0.132737943927056 4235 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_161 4065-0411 162.148 µM -1.11536883435443 0.195626682309572 no 2692 0.132346199556344 4199 1906281 YLR208W SEC13 SGTC_2357 9067248 200 µM -1.11572088953246 0.195538050022237 no 2693 0.132270812980675 4183 9150235 SGTC_2815 7968870 71.43 µM -1.11760213093245 0.195064848129729 no 2694 0.131868479138949 4168 2977326 YHR190W ERG9 SGTC_548 1436-0017 110 µM -1.11871824122469 0.194784434354124 no 2695 0.131630180339727 4273 9677137 SGTC_3038 9091290 49.47 µM -1.12090002503448 0.194236987247496 no 2696 0.131165210123501 4245 25236843 SGTC_1981 st071826 47 µM -1.12362262193745 0.193555156546461 no 2697 0.13058657751104 4256 11838600 SGTC_2217 6934799 96.0675 µM -1.1239083390341 0.193483688018755 no 2698 0.130525956643124 4188 675606 SGTC_3342 9147791 14.508 µM -1.12488320013868 0.193239959999394 no 2699 0.130319265925554 4150 1838168 SGTC_1322 1348-1070 12 µM -1.12697681622982 0.192717162331199 no 2700 0.129876141606284 4209 6758089 SGTC_2640 pentamidine 10.38 µM -1.12763156943014 0.192553841232338 no 2701 0.129737774205596 4201 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2180 6301957 200 µM -1.12856201097278 0.192321898249741 no 2702 0.129541321927334 4243 845462 SGTC_282 k297-0036 65.7 µM -1.12951528832149 0.192084439986931 no 2703 0.129340261955819 4217 5061378 SGTC_559 1550-0661 158 µM -1.12954899656049 0.192076046660349 no 2704 0.129333156362079 4279 5830875 SGTC_1140 3229-1848 2.98 µM -1.12988966321292 0.191991233511119 no 2705 0.129261360056079 4244 2849525 SGTC_2858 9025781 8.96 µM -1.13163758223586 0.191556428189759 no 2706 0.128893416499841 4115 4894980 YPL153C RAD53 SGTC_314 1671-0008 2.74 µM -1.13166461787543 0.191549707653346 no 2707 0.128887731106349 4104 3913060 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.1352545527252 0.190658602743663 no 2708 0.128134339135819 4211 803109 SGTC_2100 5377183 190 µM -1.13571821883623 0.190543695912916 no 2709 0.128037256599348 4241 2844202 SGTC_775 4577-0580 57.3 µM -1.13692231859516 0.190245491698597 no 2710 0.1277853805531 4280 2006902 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.1369287645241 0.190243896088531 no 2711 0.127784033107864 4209 442882 SGTC_515 4092-1064 102 µM -1.13697466991075 0.190232533015004 no 2712 0.127774437415077 4242 717353 SGTC_788 1182-0090 188 µM -1.13734748972306 0.190140263453083 no 2713 0.12769652471004 4246 5715185 SGTC_75 0159-0059 199.013 µM -1.13742725854911 0.190120524955703 no 2714 0.127679858734895 4312 5377270 SGTC_2138 5575593 77.673 µM -1.13798546799258 0.189982433357654 no 2715 0.127563275226698 4227 762213 SGTC_1317 1273-0028 910 nM -1.14154649018425 0.189102948512537 no 2716 0.126821288543086 4234 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.14207262675961 0.188973218659212 no 2717 0.126711916231521 4293 23847180 SGTC_2741 miltefosine 3.04 µM -1.14357319261278 0.188603524385086 no 2718 0.126400342208074 4245 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2399 5884133 200 µM -1.14442492369684 0.188393881992419 no 2719 0.126223728412709 4222 722445 SGTC_2723 salbutamol 83.58 µM -1.14523736293201 0.188194044768778 no 2720 0.126055422467454 4248 9884233 β2-adrenoceptor agonist SGTC_3222 9128301 49.47 µM -1.14523995484541 0.188193407440301 no 2721 0.126054885773873 4240 4911358 SGTC_3235 9132602 49.47 µM -1.14821877793041 0.187461821856902 no 2722 0.125439129622526 4237 4912240 SGTC_2159 5658611 73.75 µM -1.15327308143033 0.186224535567467 no 2723 0.124399157639754 4241 793844 SGTC_2974 9094440 9.66 µM -1.15495010799628 0.185815122537975 no 2724 0.12405542906391 4252 25236134 SGTC_3110 9122132 49.47 µM -1.15870519000846 0.184900419665296 no 2725 0.123288187294899 4331 918317 SGTC_2674 ligustilide 100 µM -1.1590925849598 0.184806213370187 no 2726 0.123209224019821 4304 5319022 A signalling regulator. SGTC_2581 avocatin a 64 µM -1.16032733271274 0.184506147852426 no 2727 0.122957780127129 4212 6710728 A skin care supplement. SGTC_571 k831-0106 44.2 µM -1.16074767868438 0.184404065533821 no 2728 0.122872263063343 4123 4783639 SGTC_2818 7996756 12.99 µM -1.16078536598917 0.184394914772005 no 2729 0.122864597827337 4278 2241621 SGTC_897 1000-0139 31.4 µM -1.16105347959966 0.184329822919393 no 2730 0.122810075770896 4214 6151020 SGTC_1509 1326-1131 80 µM -1.16359119363329 0.183714432254263 no 2731 0.122294860960172 4217 768313 SGTC_2069 5228469 200 µM -1.16416011139071 0.18357664665869 no 2732 0.122179565956942 4259 2835210 SGTC_2109 5483026 200 µM -1.16421877760488 0.183562442013548 no 2733 0.122167681196685 4265 759335 SGTC_255 tunicamycin 200.472 nM -1.16545549625436 0.183263159092724 no 2734 0.121917332279785 4175 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_49 0717-0965 32.132 µM -1.16785405936935 0.182683580605435 no 2735 0.121432818921122 4335 5889349 YGL099W LSG1 SGTC_3177 9107506 49.47 µM -1.16805287403681 0.182635591300411 no 2736 0.121392718898891 4207 8897194 SGTC_3287 9117173 37.0625 µM -1.16829125697132 0.182578061501327 no 2737 0.121344650410783 4248 2789709 SGTC_1349 flufenamic acid 69 µM -1.17036854258646 0.182077221908853 no 2738 0.120926344648718 4190 3371 A non-steroidal anti-inflammatory. SGTC_2807 7945238 51.95 µM -1.17045559111165 0.182056253024507 no 2739 0.120908837750489 4275 17148797 SGTC_2962 9082311 13.18 µM -1.17057834265813 0.182026686301481 no 2740 0.120884153415108 4237 16459453 SGTC_3053 9095903 49.47 µM -1.17322908517304 0.181388944074331 no 2741 0.120351975695593 4376 17174018 SGTC_3012 9080433 71.4286 µM -1.1737684414715 0.181259351808732 no 2742 0.12024389391306 4263 17688859 SGTC_1413 3910-0535 34.4 µM -1.17543238693673 0.180859917643597 no 2743 0.119910886320028 4284 2876951 SGTC_2449 5812982 45.77 µM -1.17635759189686 0.180638058793217 no 2744 0.119726005341474 4195 776185 SGTC_1453 4237-0541 195 µM -1.17991308008958 0.17978706212058 no 2745 0.119017393506163 4263 739892 SGTC_622 1348-1566 26.3 µM -1.1799199312287 0.179785424753559 no 2746 0.119016030933033 4265 7340407 SGTC_1113 artemisinin 1.17947 µM -1.18011196696885 0.179739533570985 no 2747 0.118977842825399 4306 2240 An anti-malaria and mitochondrial poison. SGTC_134 0269-0018 6.916 µM -1.18223567514987 0.179232517402402 no 2748 0.118556100415336 4236 4378915 SGTC_3169 9102970 49.47 µM -1.18433492170129 0.178732226170447 no 2749 0.118140255136239 4332 17027839 SGTC_3233 9132340 49.47 µM -1.18466391460474 0.178653900536283 no 2750 0.118075177678805 4275 17682950 SGTC_2393 9031399 185.94 µM -1.18522630444642 0.17852005852748 no 2751 0.117963991142987 4307 1526623 YDL150W RPC53 SGTC_1877 wortmannin 25 µM -1.18595613475334 0.178346461892927 no 2752 0.117819811469169 4276 312145 A covalent inhibitor of PI 3-kinase. SGTC_1315 1237-0019 3.69 µM -1.18656506049039 0.17820170490915 no 2753 0.117699612230504 4280 825140 SGTC_3184 9108758 49.47 µM -1.18758658728523 0.17795902863744 no 2754 0.117498162348975 4294 902885 SGTC_732 3970-1727 52.7 µM -1.18772019992284 0.177927302728513 no 2755 0.117471831373393 4351 1275699 SGTC_1943 st076331 65.2 µM -1.18853325137087 0.177734323067949 no 2756 0.117311693795228 4263 24208415 SGTC_1630 st005209 31.3 µM -1.18895264047719 0.177634831727979 no 2757 0.11722915192209 4260 3367314 SGTC_1035 k081-0041 55.2 µM -1.19118267986822 0.17710639171733 no 2758 0.116790938716107 4302 731709 SGTC_1311 1190-0148 100 µM -1.19183552471126 0.176951878823096 no 2759 0.116662871660521 4329 1961333 SGTC_3161 9100388 49.47 µM -1.19250491440588 0.176793538633069 no 2760 0.116531662466274 4357 25236368 SGTC_2414 st077232 92.9 µM -1.19293789647667 0.176691166992165 no 2761 0.116446848042942 4213 729801 SGTC_1771 st048882 4.1505 µM -1.19595575130258 0.175978685125563 no 2762 0.11585691351769 4313 4580403 SGTC_2956 9076196 2.52 µM -1.1962490075335 0.175909547708845 no 2763 0.115799700711805 4277 16423868 SGTC_3081 9117243 49.47 µM -1.19852336034093 0.175373935662346 no 2764 0.115356667147014 4248 45595589 SGTC_1555 citronellol 128 µM -1.1986645801443 0.175340712404804 no 2765 0.115329197949675 4246 8842 A terpine precursor. SGTC_1906 st060206 94.7 µM -1.20126535238589 0.174729570413512 no 2766 0.114824142953556 4314 5133468 SGTC_602 3130-1533 38.1 µM -1.2094258613293 0.172820766061793 no 2767 0.113249639043509 4344 720941 SGTC_3290 9121031 71.43 µM -1.2100786829869 0.172668642405882 no 2768 0.113124351032554 4296 17014854 SGTC_3262 9137218 49.47 µM -1.21252150444609 0.172100162027975 no 2769 0.112656407977896 4225 17650664 SGTC_1498 4478-3555 97.6 µM -1.21280740120188 0.172033707833884 no 2770 0.112601732534142 4267 3437919 SGTC_1230 0170-0365 3.77 µM -1.2143633852178 0.17167232021763 no 2771 0.112304495417346 4346 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1263 0774-1208 64.8 µM -1.21586674941386 0.171323614899489 no 2772 0.112017843149348 4335 906585 SGTC_2655 perillic acid 100 µM -1.21781448886677 0.170872510591796 no 2773 0.111647238551316 4321 5702197 An apoptosis inducer. SGTC_222 nsc-310342 10.666 µM -1.21836241226511 0.170745746423288 no 2774 0.111543141127379 4319 432556 SGTC_804 1595-0054 20.9 µM -1.21905449157627 0.170585717284124 no 2775 0.111411755477369 4251 761523 Stimulates phospholipase C. SGTC_1572 epiandrosterone 68.9 µM -1.219539360911 0.170473658423725 no 2776 0.111319772970513 4221 441302 A steroid. SGTC_2395 5646831 180.19 µM -1.22049618960603 0.17025266268023 no 2777 0.111138416567456 4310 6808628 SGTC_1646 st011709 75.6 µM -1.22103914766524 0.170127339014634 no 2778 0.111035598951443 4266 5757843 SGTC_844 0330-0132 15.3 µM -1.22187584151792 0.169934332062739 no 2779 0.1108772912666 4341 2828079 SGTC_1794 st048918 76.9 µM -1.22204727409389 0.169894803655279 no 2780 0.110844875125226 4231 672303 SGTC_695 3505-6186 243 µM -1.22205242086981 0.169893617018332 no 2781 0.110843902027695 4296 1819379 SGTC_1277 0873-0036 22 µM -1.22382930052983 0.169484258541323 no 2782 0.110508314280896 4380 5965735 SGTC_2525 harmine 47.85 µM -1.22420490305255 0.169397808134133 no 2783 0.110437470017059 4291 5280953 A monoamine oxidase inhibitor SGTC_2839 9003951 25.97 µM -1.22603065333853 0.168977988250128 no 2784 0.110093569972062 4358 2990634 SGTC_963 1269-2853 151 µM -1.2276757542627 0.168600280456865 no 2785 0.109784355801533 4287 3668223 SGTC_2623 humulene 100 µM -1.22967867545712 0.16814115194746 no 2786 0.10940872765053 4308 6187145 An anti-inflammatory. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.22985867333734 0.168099930566212 no 2787 0.109375016082432 4344 4620898 SGTC_2601 securinine 100 µM -1.23062637366645 0.167924192249431 no 2788 0.109231318264711 4293 442872 A GABA receptor antagonist. SGTC_1697 st025554 27.742 µM -1.2310577638781 0.167825492366885 no 2789 0.109150630381685 4308 1269519 SGTC_1758 st042942 75.2445 µM -1.2321217692214 0.167582213069808 no 2790 0.108951800318425 4279 669317 SGTC_592 k241-0073 46.5 µM -1.23329943079598 0.167313211859019 no 2791 0.108732035092877 4347 4230158 SGTC_132 0417-1715 25.805 µM -1.23523156614035 0.166872477095697 no 2792 0.108372167216438 4303 6769098 SGTC_2409 alverine citrate 63.97 µM -1.23560429659399 0.166787540694513 no 2793 0.108302843418536 4390 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_909 3448-9333 149 µM -1.23560735719656 0.166786843371492 no 2794 0.108302274311983 4244 3344074 SGTC_1352 1496-0991 99 µM -1.23722036485256 0.166419599894722 no 2795 0.108002641510234 4308 3000039 SGTC_893 0958-0369 48.9 µM -1.23812060856912 0.166214862994195 no 2796 0.107835671721418 4230 6819948 SGTC_51 1013-0126 23.419 µM -1.2427568146415 0.165163056790669 no 2797 0.106978730350241 4333 1627850 SGTC_715 0868-0130 184 µM -1.24340195410871 0.165017037572744 no 2798 0.106859875284013 4370 2876258 SGTC_3336 9143619 71.43 µM -1.24369910293578 0.16494980979098 no 2799 0.106805163143893 4345 45595730 SGTC_3330 9141424 71.43 µM -1.24386105885968 0.164913175898353 no 2800 0.106775351732702 4365 27261020 SGTC_1060 3448-7350 82 µM -1.24566448275526 0.1645056034292 no 2801 0.106443799068053 4247 570178 SGTC_2254 7938975 95.19 µM -1.24934387095816 0.163676090974922 no 2802 0.105769664185706 4392 2969277 SGTC_3103 9120822 49.47 µM -1.24979644116656 0.163574247582831 no 2803 0.105686958231928 4324 17141819 SGTC_2948 9070189 9.45 µM -1.25016415005488 0.163491531122817 no 2804 0.105619794885342 4269 6473636 YDL196W YDL196W SGTC_514 4466-0038 2.65 nM -1.25193613451107 0.163093302503402 no 2805 0.105296568270647 4129 5722064 SGTC_762 1165-0429 115 µM -1.2537701533954 0.16268179703361 no 2806 0.1049627802923 4328 5967793 SGTC_2279 7948423 32.93 µM -1.25699029100643 0.161960918498211 no 2807 0.104378575648758 4309 1247112 SGTC_3340 9146634 11.102 µM -1.25776171320282 0.16178853291808 no 2808 0.104238973009585 4327 4907387 SGTC_693 4161-2696 114 µM -1.26040397898028 0.16119898642974 no 2809 0.103761833506473 4377 805759 SGTC_2308 7584454 197.62 µM -1.26056467165684 0.16116317769405 no 2810 0.103732866867145 4377 893577 SGTC_3200 9114385 49.47 µM -1.26089777501687 0.161088965514549 no 2811 0.103672839973268 4339 17018030 YLR208W SEC13 SGTC_2991 9074669 71.4286 µM -1.26164940093531 0.160921592532167 no 2812 0.103537485820115 4314 17333109 SGTC_659 k018-0002 107 µM -1.26189189999481 0.160867616772641 no 2813 0.10349384352668 4300 6797879 YHR007C ERG11 SGTC_1654 st012436 41.8 µM -1.26237339694717 0.160760479583824 no 2814 0.10340722861742 4346 4323132 SGTC_2546 rhodinyl acetate 100 µM -1.26641798827436 0.159862363322324 no 2815 0.102681737061034 4284 6708682 SGTC_2076 5212012 200 µM -1.27045297864049 0.158969655710054 no 2816 0.101961661044354 4311 604802 SGTC_1056 3448-1962 115 µM -1.27311177639079 0.158383207970669 no 2817 0.101489190329053 4323 715507 SGTC_1141 3253-0389 52.6 µM -1.27486728568454 0.157996776357393 no 2818 0.101178109999294 4338 5402031 SGTC_23 0213-0011 39.996 µM -1.27548446990197 0.157861065824284 no 2819 0.101068908775954 4342 627608 SGTC_1217 1183-1422 255 µM -1.27619516111043 0.157704889211243 no 2820 0.100943269376835 4376 2849664 SGTC_886 0866-0150 153 µM -1.27760346914709 0.157395709065466 no 2821 0.10069463837494 4405 271463 SGTC_2460 5552655 174.22 µM -1.27942621390518 0.156996135362519 no 2822 0.100373503820665 4364 5401989 SGTC_325 2810-4341 181 µM -1.28380970264063 0.156037941442653 no 2823 0.0996042739187433 4355 774970 SGTC_1818 st052136 56.3 µM -1.28394538159601 0.156008344783607 no 2824 0.0995805334254358 4016 674169 SGTC_833 3852-0053 558 µM -1.28411136082268 0.155972143533107 no 2825 0.0995514967506572 4404 3123681 SGTC_1302 1159-0335 255 µM -1.28539740099342 0.155691836687736 no 2826 0.0993267244835901 4369 649284 SGTC_758 0868-0029 16 µM -1.28547530800572 0.155674866661698 no 2827 0.0993131199359541 4346 762687 SGTC_845 0330-0138 4.51 µM -1.28728517387183 0.155280977585727 no 2828 0.0989974546254224 4300 9039800 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.28777727203041 0.15517399393572 no 2829 0.0989117530374975 4401 1273210 SGTC_754 3474-0146 171 µM -1.2899380449847 0.154704811297238 no 2830 0.0985360850094247 4344 24762078 SGTC_2075 5212009 200 µM -1.2899664100711 0.154698658441929 no 2831 0.0985311604632204 4279 780898 SGTC_2488 5268135 45.7 µM -1.29143841833183 0.154379577484491 no 2832 0.0982758480163181 4394 1270356 YLR208W SEC13 SGTC_2871 9038510 12.99 µM -1.29170006311137 0.154322907439424 no 2833 0.0982305178063252 4338 4945164 SGTC_2739 tacrine 100.86 µM -1.29304833279973 0.154031101733516 no 2834 0.0979971715752696 4406 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_594 1487-1584 10.8 µM -1.29520684389072 0.153564696195219 no 2835 0.0976244422660658 4309 5013332 SGTC_336 4111-0029 111 µM -1.29877062768537 0.152796691729535 no 2836 0.0970113287742098 4364 3131175 SGTC_2353 9059630 146.67 µM -1.29958865970845 0.152620763832165 no 2837 0.0968709942408074 4394 4779114 SGTC_3300 9124615 50.48 µM -1.29960614455067 0.152617004968197 no 2838 0.0968679963196233 4412 24824903 SGTC_46 0329-0187a 2.197 µM -1.30492437409644 0.151476550468996 no 2839 0.0959593003068363 4402 46494817 SGTC_1545 lovastatin 49.4 µM -1.30818751065243 0.150779607406505 no 2840 0.0954048585795124 4401 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_113 0099-0221 2.5 µM -1.31015700574606 0.150359995970812 no 2841 0.0950713635128629 4344 89219 SGTC_1059 3448-6867 171 µM -1.31099508504789 0.150181674928706 no 2842 0.0949297120674016 4338 3934407 SGTC_2309 7664088 163.95 µM -1.31156948232682 0.150059539871956 no 2843 0.0948327177742382 4366 704922 SGTC_1004 4084-0029 199 µM -1.31167334943224 0.15003746150709 no 2844 0.0948151862902895 4381 716894 YLR208W SEC13 SGTC_2564 betulinic acid 100 µM -1.31169266453434 0.150033356058471 no 2845 0.094811926403088 4407 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3191 9110352 49.47 µM -1.31176698350038 0.150017560169714 no 2846 0.0947993840635556 4329 17122424 SGTC_509 pifithrin 175 µM -1.31368194841901 0.149610932406622 no 2847 0.094476629103493 4447 4817 A p53 inhibitor. SGTC_1387 3342-1166 1.8 µM -1.31647955612944 0.149018205600207 no 2848 0.0940065678776344 4353 3418228 SGTC_1154 4088-0362 150 µM -1.3194032438423 0.148400444882131 no 2849 0.0935171689419868 4385 6618304 SGTC_1552 6-methylflavone 10.6 µM -1.31947971550183 0.148384309818941 no 2850 0.0935043935762297 4328 689013 SGTC_805 3852-0218 479 µM -1.32019199098572 0.148234080310944 no 2851 0.0933854626473655 4344 6615355 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.32470934595746 0.147283672605996 no 2852 0.092633786078704 4312 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3150 9097574 49.47 µM -1.32513255369878 0.147194843503538 no 2853 0.0925635953043106 4420 17217476 SGTC_1033 k072-0102 21.3 µM -1.325402312186 0.147138241346638 no 2854 0.0925188752675166 4351 5965931 SGTC_2022 5136654 200 µM -1.32544078962045 0.147130168996521 no 2855 0.0925124978561423 4386 1713771 SGTC_1651 st011928 86.1 µM -1.33020734639308 0.146132468465384 no 2856 0.0917249821742262 4394 720198 SGTC_2671 danthron 100 µM -1.33026629622665 0.146120158037582 no 2857 0.0917152738540274 4379 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_749 1000-0129 128 µM -1.33240176684543 0.145674679769968 no 2858 0.091364100919351 4429 708470 SGTC_729 4092-0585 94.1 µM -1.33245992533054 0.145662560175662 no 2859 0.0913545508609185 4397 2169061 SGTC_1880 MG-132 525 µM -1.33271098840502 0.145610249147608 no 2860 0.0913133329180026 4343 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_105 0111-0055 734.78 µM -1.33323937134401 0.145500197546764 no 2861 0.0912266314041186 4405 5179370 SGTC_739 1486-1183 203 µM -1.33401370383865 0.145339020649964 no 2862 0.0910996827157345 4390 4346692 SGTC_2303 7774051 200 µM -1.33627063103496 0.144869927897138 no 2863 0.0907304161259547 4394 2953184 SGTC_1423 4048-0112 5.59 µM -1.33651892313846 0.144818383750387 no 2864 0.090689859796502 4454 X1423 SGTC_1452 4194-0072 190 µM -1.3393208861028 0.144237566892906 no 2865 0.0902331160979565 4451 1343545 SGTC_736 0958-0254 92.6 µM -1.34176878580029 0.1437314304894 no 2866 0.0898354880136961 4457 6812352 SGTC_2434 5670830 169.91 µM -1.34298982821141 0.143479411962479 no 2867 0.0896376337687592 4413 1549830 SGTC_3294 9122953 26.2835 µM -1.34490501599006 0.143084725691715 no 2868 0.0893279551001968 4365 16459826 SGTC_2905 7799065 20.05 µM -1.34571276980783 0.142918482066958 no 2869 0.089197583242463 4284 1296806 SGTC_1395 3486-0190 4.35 µM -1.34617820210099 0.142822750854545 no 2870 0.0891225265682025 4371 6748079 SGTC_444 curcumin 90.4 µM -1.34829525702706 0.142387857032852 no 2871 0.0887817185125014 4314 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1624 st003710 6.25 µM -1.34982586955763 0.142073991069184 no 2872 0.0885359223398154 4435 24207033 SGTC_1970 st070122 35.8 µM -1.35231612064122 0.141564343960428 no 2873 0.0881371047737884 4413 102928 SGTC_1976 st070609 63.5 µM -1.35287885324598 0.141449348632077 no 2874 0.0880471680759886 4352 682556 SGTC_1810 st050138 53 µM -1.35567436086408 0.140879020584792 no 2875 0.0876014002888609 4409 3444541 SGTC_2366 9070441 60.58 µM -1.35790331365272 0.140425398044535 no 2876 0.087247182899441 4376 6837235 SGTC_949 1165-0505 146 µM -1.36175384899063 0.139644099839118 no 2877 0.086637790391389 4390 6244267 SGTC_776 4476-4378 112 µM -1.36209330739998 0.139575363614151 no 2878 0.0865842200818346 4461 2892008 SGTC_2219 9098279 200 µM -1.36501059637322 0.138985596425287 no 2879 0.0861248597958548 4354 902349 SGTC_3080 9117754 49.47 µM -1.36576127347636 0.138834112322311 no 2880 0.0860069526146623 4399 9550191 SGTC_892 0929-0076 29 µM -1.36590950229243 0.138804213546027 no 2881 0.0859836849305812 4391 5751038 SGTC_564 3555-0129 330 µM -1.36773982844485 0.138435385488279 no 2882 0.085696764133194 4310 563260 SGTC_1142 3253-1408 9.78 µM -1.36948569876566 0.138084198997212 no 2883 0.0854237510846767 4427 256655 SGTC_2476 5806916 10.51 µM -1.37015708334016 0.137949310072824 no 2884 0.0853189359401055 4319 2870194 SGTC_1751 st044839 27.194 µM -1.3708843031132 0.137803304647307 no 2885 0.0852055126518494 4460 5291326 SGTC_2545 solidagenone 89.61 µM -1.37292859074722 0.137393433720278 no 2886 0.0848872736643936 4311 6708572 An anti ulcer agent SGTC_1546 5-methoxyflavanone 78.7 µM -1.37320766130687 0.137337545908333 no 2887 0.0848438993217858 4435 147795 SGTC_2134 5324836 1.464 µM -1.37373550789406 0.137231879648709 no 2888 0.0847619045843852 4394 699272 SGTC_79 0052-0007 94.094 µM -1.37683302032097 0.136612927436257 no 2889 0.0842819396513697 4403 2801472 SGTC_2080 5212524 12.4 µM -1.37878897355368 0.136223069043258 no 2890 0.0839799136898399 4375 260183 SGTC_549 1661-1316 519 µM -1.38031906011447 0.135918625141151 no 2891 0.08374421446983 4436 2857282 SGTC_2717 st081029 62.2815 µM -1.38049936057825 0.135882781160571 no 2892 0.083716473194827 4403 5292846 SGTC_2143 5623677 140.463 µM -1.38245190264252 0.135495027688434 no 2893 0.0834164944636627 4367 5375313 SGTC_477 mead ethanolamide 10 µM -1.38270707583869 0.135444409160752 no 2894 0.0833773507060215 4392 16061185 SGTC_1746 st038117 42 µM -1.38346699813917 0.135293740677529 no 2895 0.0832608598472241 4453 2898218 SGTC_2073 5212005 126 µM -1.38423198277819 0.135142184575078 no 2896 0.0831437165981567 4316 691789 SGTC_1231 0242-0792 125 µM -1.38472206555938 0.135045152275138 no 2897 0.0830687346435917 4419 3707635 SGTC_2047 4141938 200 µM -1.38489650244202 0.135010626760972 no 2898 0.0830420583293779 4438 3807862 SGTC_2710 st078562 53.7235 µM -1.38491132234655 0.135007693802404 no 2899 0.0830397922454023 4383 17250908 SGTC_1942 st076330 65.2 µM -1.38685497406925 0.134623410735768 no 2900 0.0827429949569067 4484 24208414 SGTC_2010 4012422 159 µM -1.38708382265686 0.134578214096708 no 2901 0.0827081021742136 4380 952393 SGTC_3237 9133362 49.47 µM -1.38719818481846 0.134555631951336 no 2902 0.0826906694062035 4385 43845137 SGTC_293 4049-0273 38.5 µM -1.38781946827015 0.134432997721592 no 2903 0.0825960125292626 4294 1380311 SGTC_2292 7671323 168.05 µM -1.38837411941332 0.134323580798968 no 2904 0.0825115764770436 4453 937504 SGTC_1244 0416-0015 52.5 µM -1.38908917883421 0.134182610143988 no 2905 0.0824028169430184 4395 96201 SGTC_2299 7976368 114.88 µM -1.38990192366872 0.134022504698969 no 2906 0.0822793307005899 4441 2979718 SGTC_2752 diclazuril 33.15 µM -1.39033196022121 0.133937843417369 no 2907 0.0822140485190226 4349 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2243 6634756 200 µM -1.39045665035441 0.133913302549614 no 2908 0.082195127091135 4462 885676 SGTC_2533 agelasine 13.65 µM -1.39303622258676 0.13340629765001 no 2909 0.0818044186849177 4482 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_669 0108-0021 26.2 µM -1.39590751970285 0.13284351003075 no 2910 0.0813711729626169 4450 17201 SGTC_1540 guanosine 70.6 µM -1.39736894252491 0.132557693037929 no 2911 0.0811513267753845 4357 6802 Guanosine is a purine nucleoside SGTC_398 bronopol 33.3 µM -1.39858821164997 0.132319559533311 no 2912 0.0809682516929351 4363 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1904 st060225 78 µM -1.39882596390176 0.132273158896568 no 2913 0.0809325891869993 4410 66595 SGTC_2448 5185112 27.17 µM -1.40267043076722 0.131524414893969 no 2914 0.0803575693617707 4429 5718189 SGTC_1752 st044819 83.042 µM -1.4030340389113 0.13145375072208 no 2915 0.0803033444171051 4382 441209 YML126C ERG13 SGTC_702 1488-0190 94 µM -1.40346853643334 0.131369344176714 no 2916 0.0802385839962221 4480 949357 SGTC_607 4491-0986 66.8 µM -1.40457631958577 0.131154312882805 no 2917 0.0800736511885659 4436 698981 YDR232W HEM1 SGTC_690 glyoxal 20.3 µM -1.40670586601185 0.130741630769876 no 2918 0.0797573127967422 4239 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2164 5685496 200 µM -1.40709373892105 0.130666562108377 no 2919 0.0796997972276365 4355 759046 SGTC_2740 felodipine 17.08 µM -1.40865661761757 0.130364385587491 no 2920 0.0794683643176224 4496 3333 L-type calcium channel blocker SGTC_1130 3454-2858 15.9 µM -1.41039079724274 0.130029654861098 no 2921 0.079212160627773 4406 715628 YIL048W NEO1 SGTC_780 0109-0199 192 µM -1.41287559286031 0.129551078124375 no 2922 0.0788461533301046 4486 610414 SGTC_1116 jasmonic acid  1.58368 µM -1.41681714518261 0.128794432655201 no 2923 0.0782681978125608 4488 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_182 3448-4371 550.524 µM -1.41682699000145 0.128792546627311 no 2924 0.0782667582858424 4360 3491403 SGTC_3087 9117406 49.47 µM -1.41793578260271 0.128580251515419 no 2925 0.0781047571288674 4455 42546093 SGTC_1346 1488-2224 62.4 µM -1.41813783190874 0.12854159229423 no 2926 0.0780752639494019 4467 3722427 SGTC_2281 7943571 200 µM -1.41968034897378 0.128246719777175 no 2927 0.0778503808109237 4540 1244024 SGTC_1645 Cervolide 78 µM -1.41972605613512 0.128237989420816 no 2928 0.0778437246833886 4461 23173 A fragrance. SGTC_1143 3454-2408 5.08 µM -1.41983648155021 0.12821689917244 no 2929 0.0778276457109587 4452 X1143 SGTC_1814 st052110 31.539 µM -1.42196431937984 0.127810971885199 no 2930 0.0775183046811419 4382 674163 SGTC_3232 9132874 49.47 µM -1.42260819423522 0.127688316189739 no 2931 0.0774248836241344 4415 3784940 SGTC_803 4488-1585 147 µM -1.42292457956179 0.127628075986221 no 2932 0.0773790100036901 4447 747204 SGTC_3324 9138759 60.749 µM -1.43468577340281 0.12540273603712 no 2933 0.075688330015926 4481 45595710 SGTC_2053 5265679 138 µM -1.43614828892483 0.125127917972045 no 2934 0.0754800749249898 4373 764595 SGTC_1445 4239-0156 97.7 µM -1.43781356555376 0.124815511948096 no 2935 0.0752434796385373 4494 4008346 SGTC_1785 bathophenanthroline 24 µM -1.43854186648462 0.124679054083794 no 2936 0.0751401836803587 4386 72812 An iron chelator. SGTC_1815 st051655 58.2 µM -1.44226018587519 0.123983997635862 no 2937 0.0746144937271999 4399 5984156 SGTC_1497 4476-2978 41.3 µM -1.44383685032473 0.123690095759278 no 2938 0.074392436783371 4498 1528379 SGTC_1682 st012968 530 nM -1.44596257690367 0.123294617367303 no 2939 0.0740938492831895 4445 24207270 SGTC_993 3909-8757 62.7 µM -1.44807737206871 0.122902052713676 no 2940 0.0737977065616556 4412 4288324 YLR208W SEC13 SGTC_2231 micatex 6.853 µM -1.44827690544564 0.12286505908027 no 2941 0.0737698119237318 4493 20737 An antifungal of unknown mechanism. SGTC_2381 9035592 200 µM -1.45632160185426 0.121380065960831 no 2942 0.0726518683086538 4481 4749657 SGTC_1856 st057054 55.7 µM -1.45824689869874 0.121026549316121 no 2943 0.0723862505209735 4454 1266018 SGTC_2793 7325131 81.82 µM -1.45991688054594 0.120720499949335 no 2944 0.0721564596466864 4423 4176441 SGTC_1466 k213-0079 57.5 µM -1.46082476359404 0.120554345471066 no 2945 0.072031769029674 4446 3657981 SGTC_340 k038-0059 454 µM -1.46151620072718 0.120427911494205 no 2946 0.0719369164272129 4446 23733424 SGTC_237 nikkomycin 200 µM -1.46192410103379 0.120353367965269 no 2947 0.0718810048551186 4494 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2821 7996764 71.43 µM -1.46259773855601 0.120230332296828 no 2948 0.0717887412129177 4466 2987135 SGTC_3091 9116372 49.47 µM -1.46321356698229 0.120117932657813 no 2949 0.071704474796293 4520 17169793 SGTC_609 0986-0026 86.3 µM -1.46451875652009 0.119879957188006 no 2950 0.0715261310178788 4461 2848610 SGTC_577 r071-0003 38.6 µM -1.46817913082247 0.119214334254266 no 2951 0.0710277857298764 4431 4568517 YMR134W ERG29 SGTC_3021 9087658 49.47 µM -1.46943701265083 0.118986197385552 no 2952 0.0708571471991031 4486 25237042 SGTC_266 formosanin C 406 nM -1.4698077786211 0.118919011945919 no 2953 0.0708069109160188 4337 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.4709519368913 0.118711851221052 no 2954 0.0706520577150572 4523 165506 SGTC_2718 lomofungin 53.02 µM -1.4781534756182 0.117413796169657 no 2955 0.0696833517183824 4458 5351222 A RNA synthesis inhibitor. SGTC_2619 obliquin 87.91 µM -1.47877067188981 0.117303017882412 no 2956 0.0696008083763382 4457 6708593 A bioactive alkalod. YER133W GLC7 SGTC_106 0092-0003 11.579 µM -1.47932216451301 0.117204095143652 no 2957 0.0695271158939612 4398 1072148 SGTC_2085 5307070 144.047 µM -1.47976159079142 0.117125316365026 no 2958 0.0694684411513015 4427 2840351 SGTC_2437 5741531 144.16 µM -1.48241491353276 0.116650435230087 no 2959 0.069114964084063 4495 2262990 SGTC_2297 7971671 152.32 µM -1.48282871567143 0.11657649781126 no 2960 0.069059962296467 4479 909016 SGTC_2584 androsterone 48.74 µM -1.48997772784152 0.115304369402061 no 2961 0.0681150461010166 4391 2754130 A steroid. SGTC_2951 9072950 58.06 µM -1.49172381556063 0.114995167401241 no 2962 0.0678857815490448 4413 16488155 SGTC_304 1310-0298 97 µM -1.49350217049684 0.114680858033014 no 2963 0.0676528932633773 4235 1550234 SGTC_2270 7924575 90.91 µM -1.49401135024694 0.114590977446092 no 2964 0.0675863263306697 4460 1262135 SGTC_1117 retinoic acid 1.10837 µM -1.49517116060891 0.114386434501296 no 2965 0.0674348890098747 4529 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1691 st019933 84.6 µM -1.49780608622082 0.11392270819408 no 2966 0.067091819542601 4485 6176082 SGTC_3067 9117431 49.47 µM -1.49935780193009 0.113650245885842 no 2967 0.0668904172875354 4498 17150885 SGTC_1558 st069300 45.6 µM -1.49954555888749 0.113617309591349 no 2968 0.0668660794523168 4434 24208000 SGTC_3042 9091578 49.47 µM -1.49974764192437 0.113581867822575 no 2969 0.0668398922667007 4478 25236497 SGTC_1674 st016616 23.6 µM -1.50382474678971 0.112868499344554 no 2970 0.0663132487539858 4454 625830 SGTC_3061 glucosamine 200 µM -1.50436832755454 0.112773631540844 no 2971 0.0662432773543007 4440 91431 and experimental redox chemotherapeutic SGTC_810 3825-7150 143 µM -1.50708945859329 0.112299585132775 no 2972 0.0658938642144217 4519 22330411 YGL099W LSG1 SGTC_1852 st056254 31.4 µM -1.51311030300461 0.11125576293644 no 2973 0.0651258214826777 4465 442583 SGTC_555 4296-0685 37 µM -1.51373135987927 0.111148488012078 no 2974 0.0650469939098714 4491 2908540 YHR072W ERG7 SGTC_1816 st051957 91.6 µM -1.51466935866138 0.110986608270547 no 2975 0.064928078927873 4510 674121 SGTC_473 2-arachidonoylglycerol 10 µM -1.5155080934651 0.110842002567823 no 2976 0.0648218911356697 4348 5282280 An endocannabinoid. SGTC_3019 9081971 49.47 µM -1.51572113446551 0.11080529381963 no 2977 0.0647949406241477 4499 16451803 SGTC_1798 st045719 60.953 µM -1.51731287038494 0.110531300038878 no 2978 0.0645938551288059 4467 3980186 SGTC_2436 5633522 8.09 µM -1.51845925735489 0.110334267569594 no 2979 0.0644493315026285 4494 5724242 SGTC_2402 5553605 200 µM -1.52045396444098 0.109992032772653 no 2980 0.0641984602218273 4544 6758546 SGTC_826 1683-5028 118 µM -1.52220640858292 0.109691992489717 no 2981 0.0639786849325813 4536 722377 SGTC_228 caffeine 993.056 µM -1.5227244826323 0.109603404386983 no 2982 0.0639138250591468 4499 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1655 st012546 55.1 µM -1.52437314695167 0.109321832813171 no 2983 0.0637077620778407 4500 720985 YLR208W SEC13 SGTC_3335 9143315 29.6265 µM -1.52782067095204 0.108734718410674 no 2984 0.0632785342657492 4511 4899691 SGTC_2225 6654152 15.4 µM -1.53083918470514 0.108222529273765 no 2985 0.0629045712831544 4458 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_635 k038-0028 24.7 µM -1.53213205984074 0.108003682916299 no 2986 0.0627449249007326 4524 4035102 SGTC_1811 st050069 61.5 µM -1.53352253717416 0.107768671175358 no 2987 0.0625735790240182 4508 3877702 SGTC_427 1354-0053 47.3 µM -1.5366784783876 0.107236636653362 no 2988 0.062186031958767 4533 6813657 SGTC_1124 fisetin 1.16336 µM -1.53961706257876 0.106742949636842 no 2989 0.0618268619447494 4527 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1831 st055328 12 µM -1.53992143197401 0.106691908966406 no 2990 0.0617897529686254 4500 1103068 SGTC_2877 9040724 71.43 µM -1.53993805866581 0.106689121291126 no 2991 0.0617877263291312 4482 6463895 SGTC_1693 xanthone 101.9 µM -1.5407173035416 0.106558529986294 no 2992 0.0616928017984748 4563 7020 An insecticide. SGTC_941 3237-0776 460 µM -1.54210940711745 0.106325518818644 no 2993 0.0615235046818268 4533 760008 SGTC_1653 st012112 65 µM -1.54583466081811 0.105703793885338 no 2994 0.0610722518964567 4498 720429 SGTC_440 fluspirilene 35.1 µM -1.54689643781815 0.105527071258646 no 2995 0.0609441100885804 4532 3396 An atypical antipsychotic. SGTC_3266 9136860 49.47 µM -1.54711398073425 0.105490889710135 no 2996 0.0609178816291972 4277 4871271 YPR165W RHO1 SGTC_2490 carminic acid 95.39 µM -1.54752003551184 0.105423379037319 no 2997 0.0608689485034514 4513 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1469 k284-2957 126 µM -1.55188885208808 0.10469899572952 no 2998 0.0603444103881753 4528 23884841 SGTC_3171 9103192 49.47 µM -1.55400849759802 0.104348843892338 no 2999 0.0600911948440459 4597 13018434 SGTC_2326 6164455 177.58 µM -1.55442271573612 0.104280516953232 no 3000 0.0600418091326375 4455 2888790 SGTC_2817 7995342 71.43 µM -1.55849919599364 0.103609814513874 no 3001 0.0595574792204228 4504 18879975 SGTC_3134 9127454 49.47 µM -1.55900493941915 0.103526823414461 no 3002 0.0594976055437358 4563 24262820 SGTC_2275 7947463 200 µM -1.55907237102061 0.103515761720961 no 3003 0.0594896260539303 4476 1225414 SGTC_1925 st057770 10.1 µM -1.55967146541252 0.103417522042181 no 3004 0.0594187693015623 4523 5989122 SGTC_3015 9080845 49.47 µM -1.56194318193176 0.103045620146425 no 3005 0.0591506872689834 4567 5296973 SGTC_2492 derrusnin 100 µM -1.56649510441311 0.102303351829311 no 3006 0.0586163768932947 4555 1715307 Part of coumarin class of compounds. SGTC_384 k007-0144 5.16 µM -1.56701205336829 0.102219301038003 no 3007 0.0585559371293727 4485 6824886 SGTC_1791 st048313 56.1 µM -1.56779468374216 0.102092148679477 no 3008 0.0584645279993228 4543 1204976 SGTC_2524 avocatin b 10.57 µM -1.57005076458977 0.10172625191603 no 3009 0.0582016508084583 4547 6710748 SGTC_825 1988-2224 89.6 µM -1.57410333672641 0.101071395212163 no 3010 0.0577317806485255 4520 1180859 SGTC_270 tamoxifen 5.46 µM -1.57691393297399 0.100619037797612 no 3011 0.0574076650774663 4535 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2216 7189485 200 µM -1.57794703302845 0.100453135039944 no 3012 0.0572888893120632 4557 731273 SGTC_3312 9133330 71.43 µM -1.58004207201827 0.100117311327929 no 3013 0.0570486159498209 4539 17617324 SGTC_2227 7312221 64.1025 µM -1.58045304006595 0.100051531589954 no 3014 0.0570015765390792 4636 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_82 0054-0107 293.755 µM -1.5814167771219 0.0998973991690593 no 3015 0.0568913869492521 4510 3104697 SGTC_1223 0764-0573 147 µM -1.58573855031075 0.0992083416012636 no 3016 0.0563993151747181 4536 1609797 SGTC_2272 7805186 180 µM -1.5879602441705 0.0988554733126764 no 3017 0.0561476646148356 4541 2956062 YPR165W RHO1 SGTC_585 0kpi-0023 191 µM -1.58879137732368 0.0987237020015146 no 3018 0.0560537503145782 4478 64601 SGTC_435 c-PAF 6.7 µM -1.5889818002688 0.0986935296632928 no 3019 0.0560322508335146 4458 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1753 st043925 64 µM -1.59071228254322 0.0984196456643085 no 3020 0.0558371707283645 4563 670181 SGTC_1973 st070275 50.2 µM -1.59321331102254 0.0980247911366945 no 3021 0.0555561730488035 4519 17118334 SGTC_2124 5246320 200 µM -1.59711462527645 0.0974111834513288 no 3022 0.0551200793319329 4537 579342 SGTC_2040 5100729 123 µM -1.59957703053192 0.0970253438555762 no 3023 0.0548462237034545 4578 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1084 voriconazole 435 nM -1.60058704079058 0.0968674080242322 no 3024 0.0547342072193952 4564 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_135 0933-0004 26.348 µM -1.60118040972173 0.0967747106814399 no 3025 0.0546684832632743 4472 21230617 YGL099W LSG1 SGTC_2228 7354201 200 µM -1.60382723757865 0.0963620109877257 no 3026 0.0543760694876762 4640 753451 SGTC_596 1155-0152 116 µM -1.61191236328796 0.0951093705398017 no 3027 0.0534905057292991 4562 280313 SGTC_2763 lisinopril 49.32 µM -1.61598045129041 0.0944836495013782 no 3028 0.0530492699143106 4461 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_816 0325-0417 81.3 µM -1.61992888298634 0.0938792406951959 no 3029 0.0526237772935815 4584 68101 SGTC_1571 st070080 73.4 µM -1.62080149124488 0.0937460514763847 no 3030 0.0525301092975103 4546 4315245 SGTC_977 1348-1378 135 µM -1.62169363010874 0.0936100255036362 no 3031 0.0524344816965141 4536 X977 SGTC_3064 1327-0027 10 µM -1.62245340168631 0.0934942967617767 no 3032 0.052353151441086 4528 16000455 YPR107C YTH1 SGTC_771 0250-0039 27.3 µM -1.6283884751638 0.0925938985270955 no 3033 0.0517212698943289 4507 3005115 SGTC_1205 4161-2785 76 µM -1.63356972316561 0.0918131196212632 no 3034 0.0511746147546547 4552 3498106 SGTC_588 3970-1144 52.9 µM -1.63473260902567 0.0916385526689453 no 3035 0.0510525567293251 4473 1888707 SGTC_368 fentichlor 4.58 µM -1.63786183155975 0.0911700299700152 no 3036 0.0507252598274862 4563 7329 A pesticide. SGTC_53 0973-0023 39.979 µM -1.63922607247598 0.0909663260047817 no 3037 0.0505830929013019 4483 674768 SGTC_158 k038-0087 26.446 µM -1.64610459273962 0.08994438874319 no 3038 0.0498711135234509 4474 X158 SGTC_1873 rapamycin 2 nM -1.64634239194974 0.0899092122719228 no 3039 0.0498466431719945 4520 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1920 st075728 45.7 µM -1.64917288786752 0.0894912957231524 no 3040 0.0495561103278487 4542 3400306 SGTC_2938 9059746 27.26 µM -1.65172773147318 0.0891153207239411 no 3041 0.0492950333983347 4547 6471769 SGTC_1678 st019265 80.2 µM -1.65986964823856 0.0879249857215609 no 3042 0.0484703392956607 4553 5367020 SGTC_1048 3161-0300 24.5 µM -1.66014470409074 0.0878849810653117 no 3043 0.0484426727558004 4577 2165101 SGTC_164 4100-3994 89.624 µM -1.66030587103843 0.0878615469403049 no 3044 0.0484264676196894 4540 4615967 SGTC_3060 1327-0027 12.5 µM -1.66705626231024 0.0868842018092771 no 3045 0.047751608993758 4502 16000455 YPR107C YTH1 SGTC_1547 harmine 94.2 µM -1.66742711813575 0.0868307443342052 no 3046 0.0477147526620842 4494 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2102 5377816 72.7585 µM -1.66795608966706 0.0867545376045764 no 3047 0.0476622219253934 4604 1379702 SGTC_1718 roemerine 11.9335 µM -1.67197031567319 0.0861778528079166 no 3048 0.0472650878476782 4185 235224 An aporphine alkaloid with mutagenic activity. SGTC_2118 5526350 200 µM -1.67260827234597 0.0860864684611022 no 3049 0.0472022186635079 4579 743594 SGTC_273 hydroxyurea 18.1 mM -1.67379495156194 0.0859166750297192 no 3050 0.0470854524377382 4622 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1600 coumarin 106 71.1 µM -1.67875140154102 0.085210200925322 no 3051 0.0466002518096212 4626 100336 A hepatotoxic, DNA x-linker. SGTC_3003 9075612 71.4286 µM -1.67963269901313 0.0850850411194372 no 3052 0.0465144007631706 4590 6501993 SGTC_1796 st049173 110.4 µM -1.68236350505306 0.0846980933279749 no 3053 0.046249186822941 4566 94134 SGTC_1026 k007-1105 30.6 µM -1.68246728154832 0.0846834145529279 no 3054 0.0462391321228864 4554 7066794 SGTC_1213 1315-0166 115 µM -1.68257162404982 0.0846686576421224 no 3055 0.0462290243533925 4568 768401 SGTC_3303 9125618 40.5795 µM -1.68400688977279 0.0844658671161545 no 3056 0.0460901686141801 4568 22695467 SGTC_1251 0490-5699 265 µM -1.68618541177136 0.0841587575971386 no 3057 0.0458800464164514 4594 3883818 SGTC_1425 4048-4433 7.33 µM -1.68728473514639 0.0840041028886482 no 3058 0.0457743073828267 4655 23734946 SGTC_1953 st076800 12.1 µM -1.68880359105593 0.0837907788397216 no 3059 0.0456285377183112 4548 297591 SGTC_3014 9081533 49.47 µM -1.6908880329056 0.0834986807173378 no 3060 0.0454290946609182 4593 21367265 SGTC_914 3820-6779 408 µM -1.69126126700011 0.0834464593530009 no 3061 0.0453934570857413 4509 2893481 SGTC_2058 5236698 133 µM -1.6916647785482 0.0833900293115495 no 3062 0.045354953822091 4554 766665 SGTC_1901 st060216 58.6 µM -1.69452230446394 0.082991232266599 no 3063 0.0450830385014352 4564 688792 SGTC_1781 st038725 66.3 µM -1.69685545849161 0.0826666818856779 no 3064 0.0448619953822531 4587 4270275 YIL048W NEO1 SGTC_964 1287-0107 19.4 µM -1.70317899469225 0.0817918580574192 no 3065 0.0442672881804613 4576 51516812 YPR165W RHO1 SGTC_1104 tacrolimus 29.8 µM -1.70648467766944 0.0813373227504176 no 3066 0.0439589383595577 4648 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_898 1000-0849 28.3 µM -1.70758907625266 0.0811858920484832 no 3067 0.0438563083570988 4598 6751807 SGTC_2026 5148700 152 µM -1.70878566830453 0.0810220603566482 no 3068 0.0437453292043627 4576 79838 SGTC_367 0335-0881 7.1 µM -1.71842195057823 0.0797117909461411 no 3069 0.0428598396967213 4520 23828853 SGTC_716 1683-5115 658 µM -1.7219464482318 0.0792365807546847 no 3070 0.0425396099052964 4593 723597 SGTC_2675 theaflavin digallate 100 µM -1.72378878296514 0.0789890327900801 no 3071 0.0423729901573513 4545 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2645 abamectin 100 µM -1.72614566589127 0.0786732013964977 no 3072 0.0421606050454362 4555 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2211 7117706 200 µM -1.72644829529439 0.0786327173194877 no 3073 0.042133396807121 4577 822771 SGTC_1843 st055809 45.5 µM -1.72691765963848 0.0785699596065498 no 3074 0.042091226187858 4618 16413835 SGTC_686 1319-0111 510 µM -1.72795598946649 0.0784312616244125 no 3075 0.0419980575341849 4608 4562600 SGTC_1657 st012939 43.4 µM -1.72935911018219 0.0782441306300546 no 3076 0.0418724217291749 4588 24207257 SGTC_2421 5690543 90.72 µM -1.73197827174273 0.0778957253206858 no 3077 0.0416387155904761 4592 3397993 SGTC_737 1950-0117 57.9 µM -1.74028023341372 0.0767991629887058 no 3078 0.0409049115839585 4599 5393513 SGTC_169 k015-0017 16.025 µM -1.74266014156983 0.0764869881799449 no 3079 0.040696498953343 4566 1840002 SGTC_3108 9121785 49.47 µM -1.74323516910117 0.076411706268442 no 3080 0.0406462722838462 4486 17140271 SGTC_1079 idarubicin 2.36 µM -1.7437907762538 0.0763390204129367 no 3081 0.0405977897195349 4628 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3098 9119039 49.47 µM -1.74715321526306 0.0759002603016048 no 3082 0.0403053823087616 4596 17161528 SGTC_2684 capsaicin 100 µM -1.7486646647727 0.0757036600439071 no 3083 0.0401745006900559 4631 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_330 1488-0319 80.1 µM -1.75811408343054 0.0744833201480411 no 3084 0.0393640499705776 4632 6846614 SGTC_1008 4106-0037 6 µM -1.75944375543988 0.0743128125146546 no 3085 0.0392510827652148 4639 2905394 SGTC_407 eburnamonine 100 µM -1.76149035632208 0.0740509537147685 no 3086 0.0390777219091221 4485 3195 SGTC_2426 5582046 32.21 µM -1.76241499981304 0.0739328787274469 no 3087 0.0389996030759201 4583 2251934 SGTC_457 grayanotoxin iii 135 µM -1.76276972998437 0.0738876186487008 no 3088 0.0389696673391872 4412 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2229 7354935 190 µM -1.7630567249453 0.0738510164135526 no 3089 0.0389454614826852 4601 318112 SGTC_876 0720-0963 56.8 µM -1.77144858116066 0.0727868670567399 no 3090 0.038243068014253 4617 765861 SGTC_2874 9043904 71.43 µM -1.77271107111689 0.0726277951322545 no 3091 0.0381382978164339 4540 4463428 SGTC_2911 7942208 15.64 µM -1.77349463182232 0.0725292015935732 no 3092 0.0380733903151447 4604 1243384 SGTC_2373 9071805 200 µM -1.77359077904858 0.0725171106871342 no 3093 0.0380654320165935 4614 10149009 SGTC_362 0310-0100 9.03 µM -1.77801173541502 0.0719628234295425 no 3094 0.037700963748351 4632 790235 SGTC_570 0987-0065 62.6 µM -1.77856532337489 0.0718936455813128 no 3095 0.0376555267323713 4529 3104428 SGTC_1411 3909-8223 150 µM -1.77913023635774 0.0718231051109012 no 3096 0.037609206285058 4653 X1411 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.77962632650559 0.071761202308483 no 3097 0.0375685673899866 4590 688761 SGTC_601 0986-0029 62.9 µM -1.77989985597999 0.0717270884359949 no 3098 0.0375461756413496 4585 24747981 SGTC_2447 5741742 33.78 µM -1.78305849686404 0.0713340518245794 no 3099 0.0372883907567599 4662 1776504 SGTC_311 1315-0136 58 µM -1.78481067976027 0.0711167379029782 no 3100 0.0371460152334741 4631 6759207 SGTC_216 k038-0035 28.382 µM -1.78580754870074 0.0709933286420903 no 3101 0.0370652120351382 4574 4444231 YPR107C YTH1 SGTC_658 3253-0951 102 µM -1.78768378787755 0.0707615022998061 no 3102 0.0369135193962228 4629 1184878 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.79159005913639 0.070280713784118 no 3103 0.0365993283387826 4599 1241132 A phosphatase inhibitor. SGTC_2198 6589944 200 µM -1.79572768093142 0.0697741942721119 no 3104 0.0362689186275761 4637 5290268 SGTC_1436 4092-1007 8.32 µM -1.79697566653195 0.0696219711969116 no 3105 0.0361697414469044 4637 2881121 SGTC_1513 0337-0559 19 µM -1.79875152893578 0.0694058012827882 no 3106 0.0360289969106696 4596 775073 SGTC_2526 patulin 37.61 µM -1.79914060733135 0.0693585091537086 no 3107 0.0359982207970514 4620 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1998 st075797 76.8 µM -1.80148571645342 0.0690739887433787 no 3108 0.0358131783108912 4628 24208315 SGTC_933 2914-0560 114 µM -1.80181514103285 0.0690340934528675 no 3109 0.035787247372793 4638 463887 SGTC_889 0919-1524 82.7 µM -1.80323677126173 0.0688621291710313 no 3110 0.0356755189326517 4652 3905452 SGTC_1210 3013-0140 750 nM -1.80434553377773 0.0687282395926934 no 3111 0.0355885778965233 4650 905973 SGTC_2034 5197015 53.07 µM -1.80751715598659 0.0683463559158409 no 3112 0.0353408411002599 4625 780676 SGTC_944 3370-0224 231 µM -1.8111030898621 0.0679165608926184 no 3113 0.0350624476675226 4597 4580514 SGTC_1548 st061468 90.8 µM -1.8258694182983 0.0661686929699638 no 3114 0.0339349668488821 4682 390799 SGTC_1489 4065-0444 182 µM -1.83746758225035 0.064820430171677 no 3115 0.0330704489550811 4639 2877968 SGTC_1133 3473-0247 50 µM -1.83839612465056 0.0647134180374331 no 3116 0.0330020278830173 4600 711311 SGTC_176 1486-1328 72.834 µM -1.83906604923833 0.0646362961810875 no 3117 0.0329527359391771 4651 22310231 SGTC_3352 9151559 45.5865 µM -1.84021467460638 0.0645042323393495 no 3118 0.032868363192608 4632 17159339 SGTC_2251 lansoprazole 556 µM -1.84023189123655 0.0645022544434649 no 3119 0.0328670998938159 4629 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_280 3448-3607 3.04 µM -1.8426640463134 0.0642233146596684 no 3120 0.032689038259342 4613 626179 SGTC_523 1934-0222 13.7 µM -1.8472769335843 0.0636968468338727 no 3121 0.0323535071123144 4627 1361595 SGTC_1209 2323-2347 50.3 µM -1.84955815741107 0.0634377350517773 no 3122 0.0321886291424628 4648 5412760 SGTC_777 1315-0167 517 µM -1.85522394301149 0.0627977385052109 no 3123 0.0317821269764632 4661 4221767 SGTC_538 2922-0838 53.3 µM -1.85650698065711 0.0626535100189496 no 3124 0.0316906644781025 4664 777039 SGTC_2551 apiole 73.87 µM -1.85753743758143 0.0625378616247385 no 3125 0.0316173650042222 4596 10659 A possible DNA adduct former. SGTC_2188 6126565 140.678 µM -1.85850924418053 0.0624289481111287 no 3126 0.0315483659354668 4576 874518 SGTC_3099 9120367 49.47 µM -1.8671915633127 0.0614624447438562 no 3127 0.0309374206748884 4665 24824940 SGTC_2759 disulfiram 3.38 µM -1.87402864825785 0.0607096077650773 no 3128 0.0304632383057273 4560 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2894 9048625 32.47 µM -1.87778146502371 0.0602994586715376 no 3129 0.0302055334322804 4657 4092861 SGTC_2493 resveratrol 26.09 µM -1.8833902916128 0.0596905112150113 no 3130 0.0298237475318687 4633 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1105 epirubicin 18.1 µM -1.88561557463482 0.059450252641791 no 3131 0.0296733885378557 4669 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1590 st077108 57.8 µM -1.88579611666402 0.0594307932378559 no 3132 0.0296612172247078 4659 5489485 SGTC_156 3474-0145 5.642 µM -1.8863983143532 0.0593659225238887 no 3133 0.0296206497783558 4591 2265471 SGTC_2772 vinpocetine 57.06 µM -1.88644504681824 0.0593608906712747 no 3134 0.02961750354117 4634 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2942 9052777 62.25 µM -1.89418400028933 0.0585322125110134 no 3135 0.0291002955299622 4653 6469503 SGTC_1929 genistein trimethyl ether 50.5 µM -1.89828049821369 0.0580972556541039 no 3136 0.028829570776975 4615 136420 SGTC_2770 toltrazuril 17.5 µM -1.90118320003348 0.0577905937592864 no 3137 0.028639010401175 4599 68591 Kills coccidiodes. SGTC_2078 5212016 200 µM -1.90298063629563 0.0576013388550494 no 3138 0.0285215359777043 4586 1899708 SGTC_1321 1326-2144 215 µM -1.90884414835394 0.056987347495147 no 3139 0.0281410998706849 4646 3513030 SGTC_1878 temozolomide 1 mM -1.90993398315138 0.0568737965849225 no 3140 0.0280708569382481 4632 5394 DNA alkylating agent. SGTC_3113 9123498 49.47 µM -1.91020496088904 0.0568455908375627 no 3141 0.0280534143389517 4726 8897275 SGTC_2848 9016370 25.97 µM -1.91302784566041 0.0565524148826259 no 3142 0.0278722438852846 4633 7894410 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.91975410033116 0.0558586486203644 no 3143 0.0274444835479102 4676 75037 A free radical scavenger. SGTC_2372 9071633 200 µM -1.92587643902376 0.0552330257125369 no 3144 0.0270599020054611 4693 21321366 SGTC_110 0850-0284 111.64 µM -1.92700511565992 0.0551182962445415 no 3145 0.0269894962028398 4632 3906265 SGTC_2753 fluvastatin 17.09 µM -1.92743590859788 0.0550745560128018 no 3146 0.0269626640852129 4639 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1905 st060207 84.5 µM -1.93592443919905 0.0542182612430659 no 3147 0.0264384780185562 4666 1948547 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.93789148051675 0.0540213439791221 no 3148 0.0263182317940405 4648 6708630 An antioxidant. SGTC_2872 9044037 25.97 µM -1.94549778475776 0.0532652116086496 no 3149 0.0258575480392353 4712 6465195 SGTC_3078 9116413 49.47 µM -1.9465667930151 0.053159618615084 no 3150 0.0257933464862526 4640 17177322 SGTC_1883 5-benzylidenerhodanine 20 µM -1.95125954142748 0.0526980468896623 no 3151 0.0255130896449828 4665 1273210 SGTC_878 0828-0289 13.7 µM -1.95680044518991 0.0521571523197852 no 3152 0.0251854673631463 4650 745350 YLR208W SEC13 SGTC_990 3985-0011 41.3 µM -1.95693344886446 0.0521442231032529 no 3153 0.0251776466628637 4652 5399565 YGL099W LSG1 SGTC_3139 9095020 49.47 µM -1.95739563264085 0.0520993142563759 no 3154 0.0251504857865084 4590 25236292 SGTC_1813 st051246 8.6015 µM -1.95895789967949 0.0519477414180111 no 3155 0.0250588587023549 4650 5291959 SGTC_1179 1021-1431 9.29 µM -1.96121060561608 0.0517297985701015 no 3156 0.0249272300997808 4677 2840958 SGTC_357 1325-0123 420 µM -1.96222916660212 0.0516314946195537 no 3157 0.0248679048361407 4662 1098503 SGTC_1270 0831-1170 17.3 µM -1.96244157646035 0.0516110131233839 no 3158 0.0248555481275816 4696 6764716 SGTC_1754 st042065 16.137 µM -1.96945744764238 0.0509381348768156 no 3159 0.0244502922054929 4453 1126236 YIL048W NEO1 SGTC_2491 paeonol 100 µM -1.97202875040098 0.0506932821589661 no 3160 0.024303162280562 4671 11092 Increases levels of cortical cytochrome oxidase. SGTC_1975 st070967 30.8 µM -1.97277786291764 0.0506221243936276 no 3161 0.024260438173588 4657 261391 SGTC_466 geldanamycin 89.2 µM -1.98916943408381 0.049084923062466 no 3162 0.0233412522304319 4715 5288382 HSP90 inhibitor. SGTC_256 clotrimazole 625 nM -1.98982207163126 0.0490244992064373 no 3163 0.0233052695846132 4627 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_632 0781-2353 4.65 µM -1.99825385404471 0.0482491812898949 no 3164 0.0228445728195895 4709 6811515 YHR007C ERG11 SGTC_153 4077-0274 519.67 µM -2.00205656246168 0.0479027398589951 no 3165 0.022639324270497 4671 3121976 SGTC_1738 st035555 74 µM -2.00806858712039 0.0473590869249988 no 3166 0.0223180018952585 4660 5331140 SGTC_3160 9100216 49.47 µM -2.01099154850233 0.0470965626527383 no 3167 0.0221631747109641 4684 17191039 SGTC_193 1273-0060 1.558 µM -2.01329522817274 0.0468904820335347 no 3168 0.0220417900385787 4584 2847393 YHR072W ERG7 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.01470363276615 0.0467648468319684 no 3169 0.021967855675429 4681 6710655 SGTC_1725 st036284 20.55 µM -2.02446912449371 0.045901137888947 no 3170 0.0214609528456774 4667 707914 SGTC_1479 0549-0158 134 µM -2.02473806205963 0.0458775343005029 no 3171 0.0214471340333369 4732 5440202 SGTC_2648 atorvastatin 78.68 µM -2.02882954368629 0.0455196425984998 no 3172 0.0212378275129864 4707 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_128 0906-2981 13.371 µM -2.03248249283446 0.0452020105179277 no 3173 0.0210524171814226 4687 6740226 SGTC_873 0591-4978 488 µM -2.03472048923367 0.0450082943015713 no 3174 0.0209395026821247 4698 3305145 SGTC_1185 1319-0113 81.3 µM -2.03770010889853 0.0447514223815549 no 3175 0.0207899666499431 4718 4672763 SGTC_2719 novobiocin 32.65 µM -2.04094302357287 0.0444731948972384 no 3176 0.0206282453600324 4702 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3004 9076122 71.4286 µM -2.04501526448328 0.044125790655458 no 3177 0.0204266766154393 4682 44782551 SGTC_1137 ixabepilone 100 µM -2.04618996441526 0.0440259842222445 no 3178 0.0203688421642933 4656 154225 A novel microtubule stabilizer. SGTC_2689 tacrolimus 100 µM -2.04637115489624 0.044010605890405 no 3179 0.020359933910266 4673 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2830 7992007 71.43 µM -2.04786729342056 0.0438837883633862 no 3180 0.0202865021931089 4622 1952075 SGTC_1211 1056-0033 32.3 µM -2.04801538641878 0.0438712515711773 no 3181 0.0202792458931847 4702 6741922 SGTC_354 2783-3500 4.88 µM -2.0492832847464 0.0437640360195596 no 3182 0.0202172110893722 4687 6740761 SGTC_2379 9035213 200 µM -2.05607999277887 0.0431928940816661 no 3183 0.0198874031912227 4680 646551 SGTC_829 1635-0120 117 µM -2.05767289584451 0.0430599135416402 no 3184 0.0198107719446218 4684 285054 SGTC_2876 9059903 25.97 µM -2.062804600717 0.0426337504751465 no 3185 0.0195655983782792 4693 6916095 SGTC_2081 5214970 32.255 µM -2.06860806398513 0.0421559169040125 no 3186 0.0192914403023546 4672 2063512 SGTC_3189 9110682 49.47 µM -2.06895447212988 0.0421275326885109 no 3187 0.0192751796015252 4678 17122418 SGTC_2617 dihydrotanshinone i 20.83 µM -2.07629563119962 0.0415296366979023 no 3188 0.0189333085629832 4655 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1259 0671-0132 43 µM -2.08019944970036 0.0412145038234379 no 3189 0.0187536213541522 4650 X1259 SGTC_3252 9135871 49.47 µM -2.08153168637074 0.0411074047284095 no 3190 0.0186926334548303 4709 17682838 SGTC_742 0kpi-0133 140 µM -2.08931185015636 0.0404864531193021 no 3191 0.0183398301799555 4718 2728852 SGTC_2932 9016711 44.54 µM -2.09222742082717 0.0402557257343813 no 3192 0.0182090883419468 4674 7117328 SGTC_1692 fluoroquinolonic acid 71 µM -2.09765464574415 0.0398290802165012 no 3193 0.0179678320364683 4718 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1323 1348-1351 11.2 µM -2.10080879317949 0.0395828196953133 no 3194 0.0178288771274522 4695 6989654 SGTC_2416 tofa 880 nM -2.10409523133613 0.0393275493396813 no 3195 0.0176850703745964 4672 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_720 r052-1644 49.9 µM -2.10836593793093 0.0389978301409774 no 3196 0.0174996742014706 4702 1422863 YOR257W CDC31 SGTC_1618 st003135 44.5 µM -2.10870235075717 0.0389719533630076 no 3197 0.0174851409036312 4694 1270615 SGTC_2744 captopril 92.04 µM -2.10912465807122 0.0389394893990596 no 3198 0.0174669114851495 4741 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1597 7-benzyloxygramine 47.5 µM -2.11455045415166 0.0385243487675814 no 3199 0.0172341401238889 4614 260807 SGTC_3214 9129694 49.47 µM -2.12383097987238 0.0378226394414605 no 3200 0.0168421397387721 4687 17158655 SGTC_3181 9108277 49.47 µM -2.12568755520855 0.0376835217660034 no 3201 0.0167646419153156 4711 17097298 SGTC_85 0868-0259 160.055 µM -2.12866985738318 0.0374609253042025 no 3202 0.0166407921858098 4692 83173 SGTC_639 0833-0042 114 µM -2.13056233685552 0.0373202300201189 no 3203 0.0165626075799464 4726 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1840 st055363 71 µM -2.13197581135845 0.0372154279369889 no 3204 0.0165044175538423 4714 676033 SGTC_875 0709-0210 25.7 µM -2.13527357919165 0.0369718497314869 no 3205 0.0163693348771739 4708 6251364 SGTC_229 benomyl 22.8748 µM -2.13804440312945 0.0367682013475012 no 3206 0.0162565697888495 4734 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2602 kawain 100 µM -2.14211989476194 0.0364703311201524 no 3207 0.0160919176816737 4684 5369129 SGTC_359 0081-0058 15.9 µM -2.15847405648579 0.0352948336577997 no 3208 0.0154454966834518 4688 3494159 SGTC_2766 oltipraz 83.91 µM -2.16124824692987 0.0350985486060868 no 3209 0.0153380841583338 4703 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2002 4023503 131 µM -2.17280884420544 0.0342902110222804 no 3210 0.0148973536933846 4699 4736863 YCR052W RSC6 SGTC_2282 7944268 200 µM -2.1757710481828 0.0340855693916404 no 3211 0.0147861922819903 4695 2970414 SGTC_3295 9122362 53.5725 µM -2.17889963461105 0.0338705248252132 no 3212 0.0146695624652829 4715 4730473 SGTC_655 k060-0012 42 µM -2.18079014329793 0.033741121811328 no 3213 0.0145994709763195 4731 5994525 SGTC_3308 9128332 17.569 µM -2.18190756792358 0.0336648269260413 no 3214 0.014558177599377 4695 17332805 YDL196W YDL196W SGTC_2746 daunorubicin 9.88 µM -2.18637510335983 0.0333612122746947 no 3215 0.0143940867729217 4743 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2185 6113692 200 µM -2.19308494315754 0.0329094495848702 no 3216 0.0141506298174011 4710 874150 SGTC_1430 4049-0248 69.1 µM -2.19386499507284 0.0328572586614367 no 3217 0.0141225582895506 4733 22774488 SGTC_2823 7987624 58.44 µM -2.19468493168154 0.0328024727424264 no 3218 0.0140931031828633 4663 2239440 SGTC_1138 3761-0006 1.03 µM -2.19776921122824 0.0325970636654553 no 3219 0.0139827782791566 4732 12061087 SGTC_2041 5107442 45.335 µM -2.20412957998483 0.0321768201351799 no 3220 0.0137576162076425 4736 793005 SGTC_2048 5246248 200 µM -2.20637973605397 0.0320292225165161 no 3221 0.01367871132694 4740 677046 SGTC_1347 1493-0251 600 nM -2.22103978152388 0.0310812351454432 no 3222 0.0131741335351658 4744 3986378 SGTC_3156 9099931 49.47 µM -2.23020203827413 0.0305006355756346 no 3223 0.0128670165067621 4751 18111053 SGTC_2650 prasterone 100 µM -2.23241332446757 0.0303618633940907 no 3224 0.0127938289873821 4756 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3225 9130819 49.47 µM -2.23825226276317 0.0299979459724495 no 3225 0.0126023046179972 4712 4547121 SGTC_1625 st003711 30.1 µM -2.23929606585112 0.029933272585381 no 3226 0.0125683293479935 4712 24207034 YER133W GLC7 SGTC_1712 st032288 53.4 µM -2.2413277951533 0.029807719503708 no 3227 0.0125024248978827 4552 2883011 SGTC_352 k048-0007 5.11 µM -2.24350051627408 0.0296739373955422 no 3228 0.0124322783026407 4672 6811911 SGTC_1187 1391-0724 117 µM -2.25130883393783 0.0291972582287101 no 3229 0.0121829918413107 4755 6997986 SGTC_2935 9038016 29.96 µM -2.25485323881442 0.0289829891805458 no 3230 0.0120712711342008 4693 6463195 SGTC_2568 diosmetin 100 µM -2.25574965384682 0.0289290059487078 no 3231 0.0120431569898259 4732 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1556 plumbagin 1.48 µM -2.26091908128902 0.0286193247597452 no 3232 0.0118821341544831 4691 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2587 piperic acid 92.2 µM -2.26097209550458 0.028616163214365 no 3233 0.0118804925336179 4694 5370536 SGTC_2929 9013348 24.6 µM -2.26447249666711 0.0284080558386808 no 3234 0.011772534741791 4705 2995952 SGTC_481 bay k-8644 50 µM -2.27205771715401 0.0279614149740774 no 3235 0.0115415122515268 4723 2303 A calcium channel antagonist. SGTC_2374 9071832 200 µM -2.27205975614051 0.0279612957032574 no 3236 0.0115414506834092 4718 17381698 SGTC_2179 6298986 200 µM -2.27343771680521 0.0278807885387823 no 3237 0.0114999077142616 4714 738374 SGTC_2549 cedrol 20.94 µM -2.27654309593252 0.0277000649356491 no 3238 0.0114067621423118 4723 6708665 A sedative which affects the nervous system. SGTC_3259 9138485 49.47 µM -2.28175624888762 0.0273988707969574 no 3239 0.0112518675668254 4708 17646153 SGTC_1779 st039427 55 µM -2.30425767811198 0.026129993341472 no 3240 0.0106040915855613 4719 1124498 SGTC_3186 9110464 49.47 µM -2.31948482339141 0.0252995015451707 no 3241 0.0101843815469684 4748 17018021 SGTC_432 NS 1619 61.3 µM -2.32295421376799 0.025113405665861 no 3242 0.0100908061202148 4708 4552 A K+/calcium channel activator. SGTC_912 3474-0017 2.18 µM -2.331464841387 0.0246617553626659 no 3243 0.00986443094942242 4738 3360550 SGTC_2186 6124449 200 µM -2.33328383760255 0.0245661122572023 no 3244 0.00981662657515644 4751 3834182 YLR033W RSC58 SGTC_2108 5365811 200 µM -2.33983576313762 0.0242241870720012 no 3245 0.00964611079354907 4742 780283 SGTC_2456 5770359 74.46 µM -2.34430097417847 0.0239934586792565 no 3246 0.00953139074167797 4722 3118787 SGTC_2408 sulbentine 18.36 µM -2.36178160053963 0.0231078815337808 no 3247 0.00909367659677075 4639 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1214 0358-0031 63.7 µM -2.36400252109228 0.0229973644135396 no 3248 0.00903934477913437 4724 4301366 SGTC_612 0302-0167 22.4 µM -2.36803044509076 0.0227980632418392 no 3249 0.00894153212453281 4736 235821 SGTC_83 0170-0301 39.027 µM -2.37216870149993 0.0225948205881381 no 3250 0.00884200715241392 4758 3089716 SGTC_2575 plumbagin 510 nM -2.37291451100493 0.0225583544947526 no 3251 0.008824174076155 4689 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2354 9060492 162 µM -2.37768577649461 0.0223262374117869 no 3252 0.00871083235526847 4743 6471895 SGTC_2338 7999974 200 µM -2.38305118471281 0.0220676259027455 no 3253 0.00858490341857722 4711 315925 SGTC_2622 2-methoxyxanthone 59.94 µM -2.3892685491256 0.0217711174653968 no 3254 0.00844097861876905 4736 71034 A hepatoprotective. SGTC_445 e6 berbamine 66 µM -2.39940192795418 0.0212950670555113 no 3255 0.00821093908331025 4749 6610268 A calcium/calmodulin antagonist. SGTC_1604 st002052 72.4 µM -2.39973261470026 0.0212796814089064 no 3256 0.00820352581444474 4760 6254834 YHR062C RPP1 SGTC_3100 9120536 49.47 µM -2.40263486401814 0.0211450532132456 no 3257 0.00813871562688281 4704 16421196 SGTC_1621 st003705 32.4 µM -2.40430254331213 0.0210680201596836 no 3258 0.008101678552911 4755 24207032 SGTC_1470 k295-0292 231 µM -2.40711552221752 0.0209386217695472 no 3259 0.00803954138173377 4785 5045612 SGTC_327 1273-0057 3.96 µM -2.41471605587056 0.0205923533838871 no 3260 0.00787374020817075 4719 3108138 SGTC_2335 9018011 154.17 µM -2.42557306760357 0.020106146974805 no 3261 0.00764211933560615 4738 6458208 SGTC_2916 7875993 68.79 µM -2.43222273761679 0.0198131914825107 no 3262 0.00750323791311139 4704 1299250 SGTC_382 3229-0966 23.2 µM -2.45072635621739 0.0190170033145281 no 3263 0.00712841456415491 4772 5722370 SGTC_55 0767-0285 6.563 µM -2.45381585844799 0.0188867525445684 no 3264 0.00706746711916186 4724 3116166 SGTC_1707 st032323 6.317 µM -2.46049326260356 0.0186078297657472 no 3265 0.00693730885194328 4611 3132057 YMR211W DML1 SGTC_385 1494-0393 12.4 µM -2.46315795835353 0.0184975053770045 no 3266 0.00688596139245251 4750 3090647 SGTC_393 acivicin 6.25 µM -2.47650571956982 0.0179532248104745 no 3267 0.00663377496121942 4676 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_940 3232-1287 54.8 µM -2.4892555574185 0.0174461380156723 no 3268 0.00640054564756666 4748 1585493 YIL048W NEO1 SGTC_2301 7769476 200 µM -2.48942749305163 0.0174393842324093 no 3269 0.00639745069976899 4752 977820 SGTC_3345 9148410 3.559 µM -2.49078220458734 0.0173862480213546 no 3270 0.00637311134429 4724 4903596 SGTC_1301 naphtanilide LB 4.81 µM -2.50072771683544 0.0170003698736423 no 3271 0.00619692128361829 4784 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1239 0337-0584 35.4 µM -2.50252675797549 0.0169313561754571 no 3272 0.0061655151924485 4756 914301 YML130C ERO1 SGTC_1760 st045453 10.4495 µM -2.51227920636278 0.0165613936731587 no 3273 0.00599770706797071 4760 3323419 YIL048W NEO1 SGTC_1490 4089-0339 670 nM -2.51647058438341 0.0164045307719672 no 3274 0.00592683973019044 4775 742542 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.52990178305678 0.0159104079112471 no 3275 0.00570472299375413 4729 279621 SGTC_2079 5212404 121 µM -2.53958874630281 0.0155620025479123 no 3276 0.00554914422352431 4738 758462 SGTC_587 k089-0003 57 µM -2.55193108615837 0.0151275952016117 no 3277 0.00535638528709191 4737 9659696 SGTC_2481 5478948 45.16 µM -2.60102591215752 0.0135012402675956 no 3278 0.00464727166119572 4758 77792 SGTC_2355 9061122 103.12 µM -2.61483758747937 0.0130718368976646 no 3279 0.00446349465080519 4763 5302957 SGTC_1565 sinapyl alcohol 95.1 µM -2.63545461855298 0.0124528328296541 no 3280 0.00420123303545729 4760 5280507 A phenol propionate derived from cinnamic acid. SGTC_971 1315-0384 26.7 µM -2.6552583432381 0.0118823128632779 no 3281 0.00396238456538476 4781 6769120 SGTC_3062 9077494 49.47 µM -2.65683122660177 0.0118379878951996 no 3282 0.00394394606496841 4726 16459633 SGTC_430 0958-0115 16.4 µM -2.65744160694747 0.0118208256218973 no 3283 0.00393681146008186 4748 6833180 SGTC_1114 scopoletin 1.73284 µM -2.66290034389832 0.0116682979327045 no 3284 0.0038735176893106 4790 5280460 A coumarin with genotoxic properties. SGTC_3037 9091026 49.47 µM -2.66664072690365 0.0115647734300207 no 3285 0.00383067618699078 4694 25236398 YIL048W NEO1 SGTC_1881 5652484 16 µM -2.67665842975255 0.011291427931394 no 3286 0.00371802001122024 4768 2255129 SGTC_1326 1431-2094 10.8 µM -2.68475083705322 0.0110747338977447 no 3287 0.00362919473856821 4779 616278 SGTC_2182 6325192 200 µM -2.70314366853827 0.0105956293045349 no 3288 0.00343435253094842 4786 736248 SGTC_2696 st077691 74.316 µM -2.75664111726109 0.00930328428467843 no 3289 0.00291992038255136 4774 757133 SGTC_2377 9073351 62.6 µM -2.75676123293617 0.00930054517146718 no 3290 0.00291884807166791 4772 7337946 YHR072W ERG7 SGTC_455 paf C-16 10 µM -2.77013093231119 0.00900003955173427 no 3291 0.00280168813825278 4757 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1871 st057448 67.3 µM -2.78216634277285 0.00873683329051456 no 3292 0.00269986780998761 4781 691747 SGTC_299 1273-0059 1.44 µM -2.79042245074454 0.00856020345373388 no 3293 0.0026319654352061 4617 2848077 SGTC_1710 st031758 61.5 µM -2.79272220509955 0.00851156412613529 no 3294 0.00261332780760068 4795 5394341 SGTC_2784 7567673 72.73 µM -2.79783284268678 0.00840434262084162 no 3295 0.00257233649682677 4745 3471247 SGTC_2271 7849410 118.62 µM -2.7984816503714 0.00839081576941184 no 3296 0.00256717433244426 4754 972430 SGTC_1716 st033144 30.6155 µM -2.79890478767926 0.00838200417157307 no 3297 0.00256381273469387 4761 674617 SGTC_505 gw-5074 63.9 µM -2.80580335431665 0.0082394869530685 no 3298 0.00250956561912534 4772 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_381 3461-2219 42.7 µM -2.81111152526138 0.00813127904823434 no 3299 0.00246853348342343 4777 2883159 SGTC_507 nimesulide 162 µM -2.84136136817365 0.00753814858819751 no 3300 0.00224606890256491 4782 4495 A COX2 inhibitor. SGTC_3066 9117245 49.47 µM -2.86008801044316 0.00719036325307521 no 3301 0.00211761726414076 4788 17176980 SGTC_943 3253-1379 105 µM -2.86511866809542 0.00709938080579756 no 3302 0.0020842649848441 4773 668464 SGTC_657 3534-0529 86.7 µM -2.87492000872984 0.00692503085184895 no 3303 0.00202064934257009 4793 1049549 SGTC_1525 8-methoxypsoralen 92.5 µM -2.88811780869309 0.006696240778661 no 3304 0.00193777344461117 4782 4114 Related to psoralen; DNA damaging agent. SGTC_2349 9023730 187.07 µM -2.8917976974738 0.00663365095545754 no 3305 0.00191522253245051 4780 4126287 SGTC_664 1222-0054 14.9 µM -2.89965339318073 0.00650176426834267 no 3306 0.00186787752593581 4783 6813991 SGTC_2782 7736369 71.43 µM -2.89999470110086 0.0064960871072567 no 3307 0.00186584484249529 4763 2950836 YOL077C BRX1 SGTC_1842 st055362 61.2 µM -2.91971218281861 0.00617546936633138 no 3308 0.00175177398463598 4782 676032 SGTC_3132 9126706 49.47 µM -2.94609399599202 0.00576844175670366 no 3309 0.00160907294706003 4779 850858 SGTC_345 1362-0200 395 µM -2.94745083576456 0.00574816700749852 no 3310 0.00160202848490102 4774 1419823 SGTC_1717 st033143 58.0435 µM -2.9596004211152 0.00556942042189627 no 3311 0.00154019144908027 4770 674616 SGTC_551 k048-0028 34.9 µM -2.97474941134214 0.00535347272273172 no 3312 0.00146613987819141 4773 6836383 SGTC_967 1306-0166 352 µM -2.98015532018851 0.00527823365984281 no 3313 0.00144051131154795 4788 4437607 SGTC_1702 st027038 51 µM -2.98597377730623 0.00519830509221205 no 3314 0.00141338440862693 4803 5521182 SGTC_1903 st060211 78.3 µM -2.99009921825831 0.00514228795899733 no 3315 0.00139443421359191 4787 688960 SGTC_1927 st060202 13.8 µM -2.99930477818609 0.00501922350317774 no 3316 0.00135298236439874 4776 688887 SGTC_725 1497-0963 19 µM -3.01599115004843 0.00480282272201919 no 3317 0.00128070367889008 4800 3549977 SGTC_2999 9069765 71.4286 µM -3.07245505567133 0.00413093232234441 no 3318 0.00106152900789908 4772 2097066 SGTC_310 1273-0058 1.06 µM -3.08252604979999 0.00402034963179223 no 3319 0.00102625882547456 4512 2734232 SGTC_1602 st001878 87.6 µM -3.13352536240657 0.00350003977639928 no 3320 0.000863599955880199 4792 595405 YLR310C CDC25 SGTC_953 1188-0045 9.7 µM -3.13874647399799 0.00345034276066377 no 3321 0.000848360880767405 4775 6144426 SGTC_2880 9042983 58.44 µM -3.17387047618737 0.00313217234128205 no 3322 0.000752103996522587 4774 6464714 SGTC_2769 toremifene 3.73 µM -3.19673378997841 0.00293951477086297 no 3323 0.00069496569289755 4792 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1708 st033234 31.827 µM -3.23279529701662 0.00265727982489822 no 3324 0.000612926841494206 4803 674664 SGTC_48 0382-0018 55 µM -3.24110903508758 0.00259578840872002 no 3325 0.000595328164750987 4787 762596 SGTC_3136 9095672 49.47 µM -3.35389726393479 0.00187952966646241 no 3326 0.000398409707771309 4779 17217380 SGTC_526 4469-0568 170 µM -3.36036875366053 0.00184448417854481 no 3327 0.000389192519960218 4792 2901964 SGTC_1261 0712-0010 12.7 µM -3.367888079459 0.00180451112306213 no 3328 0.00037873169284513 4798 2840123 SGTC_2875 9039966 71.43 µM -3.39835983643589 0.00165046137502893 no 3329 0.000338955951463964 4798 6463691 SGTC_2873 9040596 71.43 µM -3.40203261681792 0.00163272604507309 no 3330 0.00033443327270291 4796 6463863 SGTC_3107 9121808 49.47 µM -3.40709811190164 0.00160855031620894 no 3331 0.000328287605658501 4788 662681 SGTC_539 4859-0462 2.54 µM -3.44051820703769 0.00145705407587035 no 3332 0.000290300686109599 4798 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_356 1634-0012 32.5 µM -3.47539469784074 0.00131294196310903 no 3333 0.000255051107725325 4800 735457 SGTC_1736 st036774 51 µM -3.48436018307023 0.00127806395612246 no 3334 0.000246657565032315 4797 1272247 SGTC_2285 7945142 200 µM -3.55284351925737 0.00103835310394162 no 3335 0.000190545541990498 4792 2970608 SGTC_501 nsc-95397 161 µM -3.62691285408734 0.000826046371891206 yes 3336 0.000143415022529164 4803 262093 SGTC_1329 1447-1697 50.6 µM -3.76192905332854 0.00053847343578921 yes 3337 8.43039401500454e-05 4806 2840515 SGTC_2566 crystal violet carbinol 226 nM -3.82477725500789 0.000439093401597714 yes 3338 6.54451862197199e-05 4772 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2412 st077135 33.4 µM -3.85574139250993 0.000396652215115004 yes 3339 5.76897061058487e-05 4798 13258915 SGTC_1266 0828-0227 32.9 µM -3.86320255340499 0.000387011235057474 yes 3340 5.59550693311463e-05 4800 3913820 SGTC_1732 st034308 51.822 µM -3.90553947753269 0.00033630137951999 yes 3341 4.70077039062294e-05 4790 830119 SGTC_2787 5284540 71.43 µM -4.07208322843964 0.000190932326041429 yes 3342 2.32972615170397e-05 4800 736958 SGTC_2995 9067767 71.4286 µM -4.34775969409305 7.13095209929739e-05 yes 3343 6.87675874786909e-06 4806 11673567 SGTC_2794 7785382 27.27 µM -4.3630680520773 6.73959316548224e-05 yes 3344 6.41255135065957e-06 4807 2205081 SGTC_2799 7812892 81.82 µM -4.5539354604154 3.282765029045e-05 yes 3345 2.63257576691195e-06 4809 20205235 SGTC_1320 1313-0481 95.3 µM -4.76195290727884 1.45046546847852e-05 yes 3346 9.58642152341904e-07 4790 6813365 YLR208W SEC13 SGTC_180 1486-1293 102.781 µM -4.96446668409021 6.33602145891093e-06 yes 3347 3.44450550913248e-07 4809 4140536