SGTCid condition conc unit SAM35|YHR083W.score SAM35|YHR083W.strain.pval SAM35|YHR083W.strain.significant SAM35|YHR083W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_103 0844-0104 51.839 µM 5.12953521655504 7.93752748926461e-07 yes 1 1.45229215697421e-07 35 5375804 SGTC_2981 9013952 38.96 µM 4.99653232349706 1.47191493766376e-06 yes 2 2.91851976857321e-07 2 2996344 SGTC_1629 st005085 44.9 µM 4.82984641656553 3.12422811838628e-06 yes 3 6.83192008282956e-07 11 24207091 SGTC_336 4111-0029 111 µM 4.52843318975745 1.14739468938421e-05 yes 4 2.97113316527073e-06 1 3131175 SGTC_125 0133-0007 11.75 µM 4.37959204257881 2.12006727098229e-05 yes 5 5.9450846427687e-06 5 26541 SGTC_1979 st071809 45.3 µM 4.29704419695802 2.95608424822897e-05 yes 6 8.65453467916663e-06 6 4976333 SGTC_2706 st078239 82.5 µM 4.28757125424987 3.0698980357892e-05 yes 7 9.03186612406119e-06 2 15434492 SGTC_1161 k007-0610 110 µM 4.16425553707706 4.98545853521711e-05 yes 8 1.56185055916859e-05 40 5843850 SGTC_2978 9011784 42.97 µM 4.14140359932458 5.4464897095266e-05 yes 9 1.72593474037123e-05 4 2994934 SGTC_43 0570-0105 72.5 µM 4.08973839261052 6.64134386280575e-05 yes 10 2.15930000700284e-05 8 1114046 YDL195W SEC31 SGTC_1631 benzylvanillin 81.9 µM 3.8247285722811 0.00017732898752108 yes 11 6.54581191087375e-05 7 75506 SGTC_684 1140-0066 328 µM 3.7753999717357 0.00021151912891619 yes 12 7.98755610027889e-05 5 6813534 SGTC_2994 9053520 71.4286 µM 3.56180355501524 0.000443323015889438 yes 13 0.000184157967772285 13 4647384 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 3.51472104467409 0.000519205706104649 yes 14 0.00022010807002465 7 23665772 A membrane-active detergent. SGTC_1372 2752-0194 270 µM 3.50095502608623 0.000543564699233878 yes 15 0.000231797035788293 3 823334 SGTC_2806 7952793 58.44 µM 3.46525324748084 0.000611749351881506 yes 16 0.000264866196308355 10 2972490 SGTC_1515 3460-0031 42.1 µM 3.4493399003265 0.000644616473723194 yes 17 0.000280979426913951 11 2876596 SGTC_2385 9074692 200 µM 3.35291442392099 0.000881190830481099 yes 18 0.000399827134204121 10 17046906 SGTC_334 1502-1024 68.5 µM 3.34058695716734 0.00091661362773792 yes 19 0.000418007479553934 4 3296216 SGTC_1150 3909-7983 10.9 µM 3.30314852770932 0.00103236713251437 no 20 0.000478028673665967 14 23965914 SGTC_2344 7990960 76.95 µM 3.28481995720136 0.00109379489463299 no 21 0.000510237792166096 53 140813 SGTC_1724 st037281 8.293 µM 3.25683288432381 0.00119407902598553 no 22 0.000563313705446689 24 574124 YDL195W SEC31 SGTC_2334 9017922 200 µM 3.2560068362978 0.0011971629251141 no 23 0.000564955154632019 9 3163164 SGTC_818 4072-2707 53.5 µM 3.2328603773074 0.00128659669406315 no 24 0.000612787231806314 17 882871 SGTC_2489 cantharidin 73.42 µM 3.20763403882873 0.00139099272313125 no 25 0.000669158396277468 20 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1475 4092-1048 11.7 µM 3.19024389570651 0.00146740403483924 no 26 0.000710763855358392 15 2881759 SGTC_2661 dactinomycin 12.96 µM 3.17135300075761 0.00155473505795719 no 27 0.000758653197826851 5 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2763 lisinopril 49.32 µM 3.08172959602379 0.00203720159175094 no 28 0.00102900847876377 7 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3200 9114385 49.47 µM 3.07203797577992 0.0020967921890063 no 29 0.00106301337723262 29 17018030 YLR208W SEC13 SGTC_1737 st035557 69.7 µM 3.06977918825318 0.00211090600464097 no 30 0.00107108542301814 15 5716916 SGTC_1326 1431-2094 10.8 µM 3.03679053815812 0.0023270868679965 no 31 0.00119555774892272 12 616278 SGTC_2297 7971671 152.32 µM 3.02554069459874 0.00240527222935527 no 32 0.00124094501797619 17 909016 SGTC_42 0133-0086 60.653 µM 3.00023981481277 0.00258986297825786 no 33 0.0013488355909725 27 162923 Model of phenazepam hydroxylation. SGTC_2862 9027634 71.43 µM 2.98913624399746 0.00267484101572738 no 34 0.00139883675236193 13 5012562 SGTC_2009 4012297 12.05 µM 2.97357314048619 0.00279818784091199 no 35 0.00147177122533567 19 45595307 SGTC_2774 tamoxifen 10.92 µM 2.97141605345791 0.00281568308325319 no 36 0.00148214950277424 13 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_264 promethazine 12.5 mM 2.96489868618658 0.00286914386648794 no 37 0.00151391313465259 40 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_465 cgp-37157 41 µM 2.93577735829281 0.00311937557153769 no 38 0.00166356512901339 3 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2980 9014342 25.29 µM 2.88652581493385 0.00358758974438166 no 39 0.00194760395707454 35 2996599 SGTC_981 1488-1094 54.9 µM 2.85455895118336 0.00392431720731232 no 40 0.00215483162828682 9 3449522 SGTC_3011 9081274 71.4286 µM 2.82618929328362 0.00424657679157002 no 41 0.0023552709072581 16 6625322 SGTC_631 k072-0230 41.5 µM 2.8149076312439 0.0043811695531559 no 42 0.00243956277535848 19 5773147 SGTC_2215 7188065 200 µM 2.81374669303324 0.00439523385278066 no 43 0.00244838987882128 8 940217 SGTC_3249 9135183 49.47 µM 2.75216491872101 0.00520159018967886 no 44 0.00296013491355175 17 4902779 SGTC_3333 9141820 12.094 µM 2.7450407587594 0.00530289408130075 no 45 0.00302516913686973 21 1939433 SGTC_2971 9092186 9.93 µM 2.74296070467364 0.00533280107217534 no 46 0.00304439856481678 28 25236400 SGTC_373 0844-0104 25.9 µM 2.73662923357515 0.00542476007937837 no 47 0.00310361043237715 30 5375804 SGTC_2236 dapsone 200 µM 2.73589132362915 0.00543556875395032 no 48 0.00311057839761433 9 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1276 0871-0068 94.2 µM 2.73210606680826 0.00549131550248343 no 49 0.00314654388933348 22 3414906 SGTC_2821 7996764 71.43 µM 2.73059792360056 0.00551366758318012 no 50 0.00316097743023731 26 2987135 SGTC_814 3342-0569 96 µM 2.72497451303726 0.00559772604445639 no 51 0.00321532254623457 15 4346283 SGTC_3055 9094636 49.47 µM 2.72267696489246 0.00563239588976181 no 52 0.00323776708583935 28 25236176 SGTC_959 1222-0044 107 µM 2.71765342771289 0.00570886571618259 no 53 0.00328733325016212 16 6083612 SGTC_2326 6164455 177.58 µM 2.71354191621847 0.00577213674926346 no 54 0.00332840730277188 38 2888790 SGTC_2307 7538926 6.34 µM 2.69788788143661 0.00601876474465348 no 55 0.00348904691509208 51 96582 SGTC_1777 st045864 34.765 µM 2.69726874905112 0.00602870831939756 no 56 0.00349554115946386 21 4691462 SGTC_120 rhodamine 6G 52.259 µM 2.68497061114583 0.00622926266226939 no 57 0.00362680920434463 57 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_772 k072-0172 35.3 µM 2.67725772247091 0.00635803637734823 no 58 0.00371137571054695 14 5861980 SGTC_745 0469-0705 296 µM 2.66576432538625 0.00655430116060303 no 59 0.00384067601652436 51 3486736 SGTC_1313 1220-0047 237 µM 2.65885483649236 0.00667485148163033 no 60 0.00392033687642438 25 3528706 SGTC_317 4495-0002 170 µM 2.64758089755467 0.00687575926990257 no 61 0.0040534980170906 17 15991618 SGTC_1062 mesoridazine 14.2 µM 2.64675171876795 0.00689074437378908 no 62 0.0040634498097803 21 4078 A neuroleptic. SGTC_2281 7943571 200 µM 2.64088099345693 0.00699766887372433 no 63 0.00413453798944456 21 1244024 SGTC_764 1951-2361 146 µM 2.6250660345789 0.00729302954589034 no 64 0.00433160819985893 36 5438930 SGTC_1732 st034308 51.822 µM 2.58306771678174 0.0081313764027073 no 65 0.00489630501064743 34 830119 SGTC_2729 fluphenazine 10.66 µM 2.56666675610923 0.0084810790104237 no 66 0.00513406200320249 30 3372 An atypical antipsychotic. SGTC_85 0868-0259 160.055 µM 2.55821765546036 0.00866633033411027 no 67 0.00526051090352214 18 83173 SGTC_1129 3453-1384 223 µM 2.55703200718408 0.00869260824983398 no 68 0.00527847516615459 36 1084452 SGTC_1468 k284-1086 134 µM 2.54053564446404 0.00906553737926557 no 69 0.00553414054746995 40 15996457 SGTC_1375 2910-0797 186 µM 2.53572234021529 0.00917695834443513 no 70 0.00561078340442611 23 742508 SGTC_761 k216-0224 480 µM 2.52915233315784 0.0093309783751868 no 71 0.00571691947507252 29 1340404 SGTC_1848 st056003 16.4 µM 2.52169406911784 0.00950855833245614 no 72 0.00583956161978128 23 146492 SGTC_3124 9127567 49.47 µM 2.47535403672871 0.0106795325809894 no 73 0.00665520785557708 24 17592030 SGTC_1463 k081-0032 34.1 µM 2.47403864608731 0.0107145284118294 no 74 0.00667976222481221 13 977755 SGTC_2779 methotrexate 400 µM 2.47081455837525 0.010800727555867 no 75 0.00674028515706878 49 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_538 2922-0838 53.3 µM 2.45487068546658 0.0112359339396455 no 76 0.00704676381476041 36 777039 SGTC_157 1348-1695 65.819 µM 2.44038090637018 0.0116445911035478 no 77 0.00733589135253489 63 5380510 SGTC_2291 7917025 104.35 µM 2.43638208205671 0.0117596179536633 no 78 0.0074175026973247 35 2964612 SGTC_523 1934-0222 13.7 µM 2.43403030526019 0.011827726673946 no 79 0.00746587243701745 39 1361595 SGTC_3041 9091929 49.47 µM 2.4303733290679 0.0119343145545889 no 80 0.00754163871212 23 25236887 SGTC_96 0929-0093 37.281 µM 2.42762458067767 0.012014978339807 no 81 0.00759903307003065 29 6991579 SGTC_2265 7929201 200 µM 2.41656179215459 0.0123444216866082 no 82 0.00783393331890849 30 1265108 SGTC_1518 st038567 90.8 µM 2.40664844950571 0.0126462544207537 no 83 0.00804982966816896 23 77966 SGTC_416 estradiol valerate 100 µM 2.38969496533968 0.0131772512180066 no 84 0.00843118563814654 25 13791 A steroid. SGTC_3078 9116413 49.47 µM 2.38227062696312 0.0134157869224251 no 85 0.00860312367230052 31 17177322 SGTC_3207 9114163 49.47 µM 2.37487396112743 0.0136571320026439 no 86 0.00877747172779694 45 849233 SGTC_2444 5485484 36.41 µM 2.37429757007755 0.013676095374188 no 87 0.00879118712504254 43 6790631 SGTC_555 4296-0685 37 µM 2.37299309791793 0.0137190966566747 no 88 0.00882229681895919 31 2908540 YHR072W ERG7 SGTC_2345 9052315 157.45 µM 2.34523921519771 0.0146620234501296 no 89 0.00950743770520985 34 6469265 SGTC_768 0384-0033 77.3 µM 2.33747672290088 0.0149355283528604 no 90 0.00970720494420071 54 3965305 YMR134W ERG29 SGTC_1086 cerivastatin 2.18 µM 2.32911649736683 0.0152349884499078 no 91 0.00992644747365122 22 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_522 1273-0010 11.6 µM 2.3066111725813 0.0160668716814413 no 92 0.0105382530687646 37 5705015 SGTC_3054 9094397 49.47 µM 2.30621168982249 0.0160819829701712 no 93 0.0105494033559919 37 2598354 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 2.30198838542666 0.0162424849096395 no 94 0.0106679135888613 31 6710655 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.28983735394514 0.0167119453818411 no 95 0.0110153734431322 42 688803 SGTC_407 eburnamonine 100 µM 2.28759986228338 0.0167996457298971 no 96 0.0110804169668109 28 3195 SGTC_3244 9134489 49.47 µM 2.28647475698906 0.0168438937084875 no 97 0.0111132496273239 37 16584271 SGTC_289 k017-0060 526 µM 2.28527619001069 0.0168911403851889 no 98 0.0111483190750759 19 5512909 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.28188077331926 0.0170256010558668 no 99 0.0112481901316522 31 229346 A bile salt which induces apoptosis. SGTC_2908 7930301 100 µM 2.28125038441203 0.017050665304042 no 100 0.0112668174220872 39 2223178 SGTC_835 0312-0010 67.2 µM 2.27780019945547 0.0171884039571993 no 101 0.0113692422239522 31 1626196 SGTC_613 3914-0030 117 µM 2.2733334174717 0.017368138583551 no 102 0.0115030475970543 10 1145395 SGTC_966 1300-0360 30.2 µM 2.2708707713454 0.0174679153434466 no 103 0.0115774010613928 53 70588 SGTC_2055 5235184 200 µM 2.24449262028711 0.0185677036797601 no 104 0.0124003616057389 34 2836034 SGTC_2067 5224629 34.075 µM 2.23294458476264 0.0190674231745466 no 105 0.0127762994737182 38 2835000 SGTC_2646 retinol 96.75 µM 2.22899890206271 0.0192407659988199 no 106 0.0129069889186774 35 445354 A vitamin A analog and teratogen. SGTC_739 1486-1183 203 µM 2.22829896165078 0.0192716554341512 no 107 0.0129302927719322 28 4346692 SGTC_2116 5511452 16.8835 µM 2.22576591479997 0.0193837951316265 no 108 0.0130149325148675 41 870744 SGTC_2952 9073731 13.78 µM 2.21881095387886 0.0196945506713608 no 109 0.0132497942424431 46 16457353 SGTC_470 aa-861 153 µM 2.21734050317363 0.0197607909563334 no 110 0.0132999160445982 52 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1487 3970-0795 2.82 µM 2.20942644161845 0.0201205570974702 no 111 0.0135724967792161 41 3765103 SGTC_1159 4092-0538 61.2 µM 2.20790209407227 0.0201904868318372 no 112 0.0136255494218146 43 717301 SGTC_2001 4023502 57.655 µM 2.19990137209117 0.0205609098967501 no 113 0.013906946678015 33 108941 YCR052W RSC6 SGTC_2234 tolnaftate 200 µM 2.18539990624505 0.0212469891330677 no 114 0.0144297688722711 12 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_596 1155-0152 116 µM 2.17971081080822 0.021521384714131 no 115 0.0146394523481578 43 280313 SGTC_2216 7189485 200 µM 2.17734153682175 0.0216365394199045 no 116 0.0147275471078961 23 731273 SGTC_1127 asiatic acid 681.4 nM 2.17354980802698 0.0218219133972742 no 117 0.0148694806743706 35 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_20 0481-0013 4.944 µM 2.16504192065646 0.022242741983024 no 118 0.0151922375420755 63 182045 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.15873055532216 0.0225593292810757 no 119 0.0154355384106077 39 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3328 9140624 29.0385 µM 2.1449991844285 0.0232612560873138 no 120 0.0159764560989156 41 4904392 SGTC_2804 7954240 19.48 µM 2.14446631142857 0.023288862211044 no 121 0.0159977709774391 46 828705 SGTC_1243 0416-0003 5.65 µM 2.13931707886347 0.0235570478506366 no 122 0.0162049987169944 52 2141977 SGTC_574 1315-0397 40 µM 2.12747330715512 0.0241837747174418 no 123 0.0166903884361702 52 6794277 SGTC_2544 sphondin 68.51 µM 2.12722482930469 0.0241970717703232 no 124 0.0167007035290959 79 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1932 st074806 40.9 µM 2.11693316477507 0.02475323925239 no 125 0.0171327602465652 51 17251235 SGTC_1151 3909-8316 15.3 µM 2.11130878685128 0.0250616890425296 no 126 0.0173728896404566 43 800431 SGTC_2603 homopterocarpin 100 µM 2.1080922310603 0.0252395337570288 no 127 0.0175115061604642 42 101795 A weak amylase inhibitor. SGTC_3066 9117245 49.47 µM 2.0951919436779 0.0259634558687132 no 128 0.0180769665768437 28 17176980 SGTC_438 sphingosine 6.67 µM 2.08884701406317 0.0263258370221735 no 129 0.0183607483867018 23 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_526 4469-0568 170 µM 2.08748420177145 0.0264042210886014 no 130 0.0184221938268508 51 2901964 SGTC_1958 st076513 41.9 µM 2.08666151567578 0.0264516333804356 no 131 0.0184593711772568 45 732122 YGL099W LSG1 SGTC_686 1319-0111 510 µM 2.0794597405586 0.0268697245632572 no 132 0.0187875572397767 61 4562600 SGTC_3349 9149703 23.001 µM 2.07863513081392 0.0269179465004984 no 133 0.0188254497198966 22 4910494 SGTC_858 0438-0351 2.77 µM 2.06422568165694 0.0277723172675231 no 134 0.0194981618078793 51 2799119 SGTC_2095 5432005 200 µM 2.06383362199595 0.0277958755983668 no 135 0.0195167470217331 42 783734 SGTC_1621 st003705 32.4 µM 2.05235876481516 0.0284927939863802 no 136 0.0200674044217301 47 24207032 SGTC_1906 st060206 94.7 µM 2.04131730909815 0.0291770536379308 no 137 0.0206096488440566 42 5133468 SGTC_394 menadione 8.33 µM 2.03433710506408 0.0296166319017469 no 138 0.0209588092494321 53 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1228 0124-0032 52.5 µM 2.02613335057 0.03014027486575 no 139 0.0213755606467909 47 X1228 SGTC_1075 aripiprazole 15.2 µM 2.0222992987195 0.030387620105668 no 140 0.0215727205216022 47 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2383 9036125 200 µM 2.00992707495452 0.0311972817192145 no 141 0.0222194538493649 38 79580 SGTC_1812 st052057 4.327 µM 2.00829531059514 0.0313053873669706 no 142 0.0223059599594858 58 3645418 SGTC_1331 1472-0049 76.2 µM 1.99889641372101 0.0319341186105601 no 143 0.0228097814300456 54 24051409 SGTC_3317 9138495 8.753 µM 1.99682789535471 0.0320738814555555 no 144 0.0229219410764579 67 17020139 SGTC_341 1486-1430 230 µM 1.99128710894744 0.032450743692102 no 145 0.0232246659344255 85 2054753 YPL210C SRP72 SGTC_2580 diallyl disulphide 81.36 µM 1.98745439378237 0.032713561345781 no 146 0.0234360325277929 58 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1539 benzyladenosine 56 µM 1.97911255128101 0.0332916492970927 no 147 0.0239016678233456 49 92208 A nucleotide analog. SGTC_1591 genipin 88.4 µM 1.97821682628366 0.0333542199973699 no 148 0.0239521256581023 59 442424 A DNA cross-linking agent. SGTC_286 k060-0067 22.9 µM 1.97699290531506 0.0334398732980777 no 149 0.0240212160751456 60 5985051 SGTC_2561 acetosyringone 100 µM 1.96592275633379 0.0342228478805643 no 150 0.0246537669808735 54 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1056 3448-1962 115 µM 1.96205985083611 0.0344995871559086 no 151 0.02487775828314 51 715507 SGTC_230 MPP+ 141.667 µM 1.96124895822447 0.0345579125071758 no 152 0.0249249941348325 54 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_422 cantharidin 155 µM 1.9557241076719 0.0349574596994084 no 153 0.0252488316197275 56 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1026 k007-1105 30.6 µM 1.95221606319113 0.0352131175648219 no 154 0.0254562789334393 63 7066794 SGTC_3348 9149464 3.537 µM 1.9502042459724 0.0353604247187998 no 155 0.025575889966636 32 1951442 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.94896034397192 0.0354517569707159 no 156 0.025650080352958 73 5282362 SGTC_1419 3993-2473 62.6 µM 1.94579862623959 0.0356847738391772 no 157 0.0258394668614631 48 704026 SGTC_1667 st014849 34.6 µM 1.94147894475451 0.036005159557473 no 158 0.0261001054450328 48 5348460 SGTC_991 3996-0057 64.7 µM 1.94022427774849 0.0360986570356393 no 159 0.0261762196296803 61 715343 SGTC_1749 st037932 54.2 µM 1.93801301070772 0.0362639240652843 no 160 0.0263108176114469 62 594497 SGTC_219 mitoxanthrone 164.414 µM 1.93460778124227 0.0365196371018532 no 161 0.0265192222207854 56 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2815 7968870 71.43 µM 1.93289540508173 0.036648783066095 no 162 0.0266245420214505 57 2977326 YHR190W ERG9 SGTC_2231 micatex 6.853 µM 1.93207666708987 0.0367106634778635 no 163 0.026675021885433 54 20737 An antifungal of unknown mechanism. SGTC_2514 salinomycin 42.74 µM 1.92286093336318 0.0374131027435937 no 164 0.0272487585835403 60 23682228 A polyether potassium ionophore. SGTC_1154 4088-0362 150 µM 1.92037265654804 0.0376046343409799 no 165 0.0274054224161087 58 6618304 SGTC_2936 9038235 15.59 µM 1.9200703457116 0.0376279587340636 no 166 0.0274245072106009 69 4749415 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.91796161803981 0.0377909835533718 no 167 0.0275579390578416 31 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1534 6-azauridine 81.6 µM 1.91702486527861 0.0378635881905223 no 168 0.0276173863922187 66 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.9145882162067 0.0380529781210458 no 169 0.0277725195483333 43 279621 SGTC_1708 st033234 31.827 µM 1.91188974932103 0.0382636190108635 no 170 0.0279451683774559 57 674664 SGTC_2801 7907800 81.82 µM 1.91007265300472 0.0384059955194606 no 171 0.0280619297535342 54 6620925 SGTC_2926 9010726 65.15 µM 1.90978964108758 0.0384282094145919 no 172 0.0280801517960628 52 2994293 SGTC_229 benomyl 22.8748 µM 1.89490497759733 0.0396113621003823 no 173 0.0290524958102168 65 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2874 9043904 71.43 µM 1.88882498575896 0.0401030942777608 no 174 0.0294576418189355 59 4463428 SGTC_2785 7756463 72.73 µM 1.88208773314861 0.04065376452792 no 175 0.0299120523093343 87 2201551 SGTC_2418 pentamidine 31.67 µM 1.87621345361339 0.0411388931871714 no 176 0.0303129877141316 75 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2377 9073351 62.6 µM 1.87612442045756 0.0411462819642948 no 177 0.0303190985609878 70 7337946 YHR072W ERG7 SGTC_3265 9137266 49.47 µM 1.86936656152292 0.0417102582340271 no 178 0.0307859167167718 38 17224265 SGTC_2575 plumbagin 510 nM 1.86613474129063 0.0419821739145491 no 179 0.0310112582324183 88 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1438 4092-1045 4 µM 1.86092277230719 0.0424237150194193 no 180 0.0313775417014254 63 1351342 SGTC_1944 st076371 56.9 µM 1.85570977544936 0.0428690929081988 no 181 0.0317474683503556 57 24208455 SGTC_2695 st077686 51.995 µM 1.85463875318558 0.0429610631174451 no 182 0.0318239151191654 52 2876092 SGTC_2417 cerulenin 830 nM 1.85246881203342 0.0431478877706301 no 183 0.0319792660238723 65 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_978 1416-0512 87.4 µM 1.85211519939972 0.043178394722718 no 184 0.0320046411828163 58 6814003 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.84849985183769 0.0434912994335171 no 185 0.0322650328973073 45 641818 YHR062C RPP1 SGTC_3033 9090887 49.47 µM 1.84813519909607 0.0435229611221196 no 186 0.0322913934361372 82 19325384 SGTC_1866 st057638 64 µM 1.8442134911103 0.043864648373043 no 187 0.0325760164944417 32 688802 SGTC_1073 triclabendazole 3.09 µM 1.84234613466387 0.0440281045605359 no 188 0.0327122677468556 56 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1063 disulfiram 1.84 µM 1.84159489367056 0.0440940016801601 no 189 0.0327672142659672 69 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3040 9091894 49.47 µM 1.83943472212025 0.0442839300997576 no 190 0.032925635491649 46 25236966 SGTC_717 1532-0246 73.2 µM 1.83893161488932 0.0443282592491909 no 191 0.0329626225271147 63 9561992 SGTC_3116 9124943 49.47 µM 1.8356898726185 0.0446147498030153 no 192 0.0332017683072377 57 41905195 YPL160W CDC60 SGTC_677 0929-0063 136 µM 1.83124041119699 0.0450103994258275 no 193 0.0335323337134635 43 1539583 SGTC_1140 3229-1848 2.98 µM 1.83113296535067 0.0450199884034763 no 194 0.0335403496056127 49 2849525 SGTC_2368 9071271 200 µM 1.82747392986642 0.0453475206740146 no 195 0.0338142712474453 45 27209959 SGTC_550 4123-0385 25.7 µM 1.82416887263687 0.0456450121844081 no 196 0.0340632729421483 55 5731123 SGTC_1325 1431-0015 227 µM 1.82192299803648 0.0458480594286372 no 197 0.0342333351018051 57 1103340 SGTC_1249 0481-0015 10.2 µM 1.81774647018392 0.0462275846605821 no 198 0.0345514458033728 76 4227577 SGTC_1045 1348-1485 165 µM 1.81068910245598 0.0468746242959037 no 199 0.0350944953445437 63 6810614 SGTC_1121 fusaric acid 630.51 nM 1.81046630574882 0.0468951686127811 no 200 0.0351117524744983 54 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.80708582511635 0.0472077731936454 no 201 0.0353744492174713 80 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_458 nppb 133 µM 1.79587181200102 0.0482567478769776 no 202 0.0362574532001656 41 4549 A chloride channel blocker. SGTC_2974 9094440 9.66 µM 1.77910346596582 0.049859980971376 no 203 0.0376114002921174 90 25236134 SGTC_539 4859-0462 2.54 µM 1.77605053305671 0.0501563949207794 no 204 0.0378622942391456 88 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1481 3346-2004 36 µM 1.77122034515907 0.0506282329887425 no 205 0.0382620336513817 67 2770522 SGTC_1205 4161-2785 76 µM 1.76982000068139 0.0507656850546769 no 206 0.0383785654681097 61 3498106 SGTC_1430 4049-0248 69.1 µM 1.76763956642401 0.0509802989242287 no 207 0.0385605894963 57 22774488 SGTC_123 0083-0120 66.675 µM 1.76756607613528 0.0509875449232045 no 208 0.038566736746573 82 16001701 SGTC_828 2074-0507 139 µM 1.75991228734689 0.0517466929053589 no 209 0.0392113398210346 64 X828 SGTC_1028 k015-0029 4.8 µM 1.75801719782856 0.0519360399847067 no 210 0.0393722915746235 82 4588309 SGTC_2367 9070478 135.38 µM 1.75493701731498 0.0522449690766803 no 211 0.03963504074675 72 572802 SGTC_922 1866-0035 480 µM 1.75488387291153 0.0522503120143767 no 212 0.0396395866158657 93 3156169 SGTC_3057 9095946 49.47 µM 1.75190648274028 0.05255034134795 no 213 0.0398949448304606 70 24540043 SGTC_1784 st039334 36.3 µM 1.75171604024896 0.0525695785251924 no 214 0.0399113236725944 80 3496984 SGTC_402 epigallocatechin gallate 10 µM 1.73382050701986 0.0544023367738819 no 215 0.0414749679375726 79 65064 An antioxidant. SGTC_1030 k029-0042 36.7 µM 1.73290528063625 0.0544974107767871 no 216 0.0415562527771712 67 6080581 SGTC_471 1-acyl-paf 4 µM 1.73205141623388 0.0545862289211894 no 217 0.0416322041508465 72 16759367 SGTC_1269 0831-0796 3.05 µM 1.72482288882173 0.0553427269671756 no 218 0.0422796977549596 77 927758 SGTC_1709 st033179 39.1045 µM 1.72392245491549 0.0554375385369747 no 219 0.0423609215090871 58 573381 SGTC_3002 9075603 71.4286 µM 1.71959989797239 0.0558944707480305 no 220 0.0427525973702453 78 20105405 SGTC_3316 9136639 10.545 µM 1.71572516558353 0.0563065846026729 no 221 0.0431061782579879 66 4903665 SGTC_76 0433-0009 400.328 µM 1.71197477985523 0.0567077506501891 no 222 0.0434506581472705 62 2841569 SGTC_1462 k081-0014 26.5 µM 1.71153100450029 0.0567553683946285 no 223 0.0434915663655073 50 3270634 SGTC_1804 st050076 49.1 µM 1.70862866979953 0.0570675701417699 no 224 0.0437598772644436 86 3895976 SGTC_446 go6976 132 µM 1.6984077006236 0.0581778062368705 no 225 0.0447154198510086 59 3501 A protein kinase C inhibitor. SGTC_1260 0700-1617 7.75 µM 1.69563134028234 0.0584822962015702 no 226 0.044977859346814 77 2853078 SGTC_2168 5727979 200 µM 1.69497471205433 0.0585544928230233 no 227 0.0450401090221918 79 695210 SGTC_204 PMA1.184 62.41 µM 1.68893628327584 0.0592217062140352 no 228 0.0456158205496161 80 2252213 YGL008C PMA1 SGTC_595 3909-8003 73.7 µM 1.68683302187027 0.0594555000841879 no 229 0.0458177319474608 78 699517 SGTC_139 0099-0334 718.624 µM 1.68603401019332 0.0595445058454921 no 230 0.0458946244268128 81 97690 SGTC_2082 5219693 150 µM 1.68390301052803 0.0597823988640641 no 231 0.0461002072220571 65 2834649 SGTC_792 4534-1957 155 µM 1.68389362878309 0.0597834478339998 no 232 0.0461011139348505 65 1717904 SGTC_297 0986-0032 24 µM 1.6738953571646 0.0609095708665874 no 233 0.0470755834165692 84 2847425 SGTC_2902 5787006 60.46 µM 1.67348115174235 0.0609565788962758 no 234 0.0471163069984846 76 591003 SGTC_2675 theaflavin digallate 100 µM 1.67348113210341 0.0609565811257641 no 235 0.0471163089300022 81 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2556 citropten 84.59 µM 1.67266704039334 0.0610490547621412 no 236 0.0471964305790679 60 2775 A potential DNA crosslinker. SGTC_2658 polymyxin b sulfate 77.05 µM 1.67134853361856 0.0611990580727671 no 237 0.0473264276242703 85 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2261 9010538 184.68 µM 1.6713469245722 0.0611992413058565 no 238 0.0473265864419398 72 6457250 SGTC_1909 st060837 51.5 µM 1.66891140573754 0.0614770822206894 no 239 0.0475674694282237 81 678937 SGTC_694 1315-0438 43.2 µM 1.66859617659085 0.0615131150592912 no 240 0.0475987185630618 61 6793154 SGTC_2809 7964133 12.99 µM 1.66715102703609 0.0616785166774348 no 241 0.0477421889339631 86 1253665 SGTC_634 1611-4317 11.2 µM 1.66625508868863 0.0617812336996431 no 242 0.0478313089170749 87 2843522 SGTC_2163 5671233 125 µM 1.66616554829901 0.0617915066098505 no 243 0.0478402229151519 91 701023 SGTC_614 0462-0418 107 µM 1.66287427127164 0.0621700387667656 no 244 0.0481688027785035 66 5188303 SGTC_1722 st034304 3.6505 µM 1.65832474231288 0.0626962588766954 no 245 0.0486259687964207 96 4036148 YLR033W RSC58 SGTC_223 busulfan 5 mM 1.65819115507349 0.062711762509501 no 246 0.0486394447448528 66 2478 A DNA alkylator. SGTC_2663 amphotericin b 100 µM 1.65493733365935 0.0630903122220257 no 247 0.048968605119425 102 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_412 gemfibrozil 100 µM 1.64895232789569 0.0637912525790481 no 248 0.0495787007804771 78 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3048 9093155 49.47 µM 1.64755609099939 0.0639556425469089 no 249 0.0497218985390779 66 25236002 SGTC_765 1319-0117 244 µM 1.64742663161553 0.0639709014929912 no 250 0.0497351925651793 78 3487746 YGL099W LSG1 SGTC_2957 9076800 11.52 µM 1.64623982967045 0.0641109178462805 no 251 0.0498571960062502 67 16459615 SGTC_2403 6032726 181.2 µM 1.64407572393685 0.0643668475841739 no 252 0.0500802808676694 73 2881040 SGTC_3113 9123498 49.47 µM 1.64396406751293 0.064380073712781 no 253 0.0500918124236037 86 8897275 SGTC_3236 9132701 49.47 µM 1.63954446372283 0.0649052906124804 no 254 0.0505499592173217 80 24282524 SGTC_1670 st016595 4.04 µM 1.63725526827032 0.0651786385814137 no 255 0.0507885716173272 79 597879 SGTC_2712 st079126 47.7 µM 1.6280676851632 0.0662847033193122 no 256 0.0517552673211043 69 3152970 SGTC_14 0354-0009 295 µM 1.62537429969925 0.0666116917296556 no 257 0.0520414142993795 87 1713507 SGTC_2839 9003951 25.97 µM 1.62212138538768 0.0670082721861964 no 258 0.0523886800174492 66 2990634 SGTC_2310 7668677 200 µM 1.6214521258422 0.0670900913076863 no 259 0.0524603546798864 114 2197143 SGTC_1257 0669-0121 16 µM 1.60908740060721 0.068615656226417 no 260 0.0537986159243092 93 4307855 SGTC_1242 0402-0103 60.1 µM 1.60470533018099 0.0691626929988208 no 261 0.0542793341840116 77 432868 SGTC_3150 9097574 49.47 µM 1.60408006128908 0.069241021782578 no 262 0.0543482031265954 76 17217476 SGTC_920 mycophenolic acid 780.421 nM 1.60377511709048 0.0692792475856616 no 263 0.0543818156400431 70 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2870 9038528 12.99 µM 1.601006779397 0.069627012299899 no 264 0.0546877088029794 79 6463316 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.60070681327183 0.0696647752717905 no 265 0.0547209357028084 65 688667 SGTC_1565 sinapyl alcohol 95.1 µM 1.60007264497199 0.0697446631205956 no 266 0.0547912343269076 86 5280507 A phenol propionate derived from cinnamic acid. SGTC_2423 st077119 87.2 µM 1.59996152329329 0.0697586686685737 no 267 0.0548035596993539 82 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1425 4048-4433 7.33 µM 1.59930218258532 0.0698418151507136 no 268 0.0548767374096911 91 23734946 SGTC_410 α-linolenic acid 100 µM 1.590562608985 0.0709511416932269 no 269 0.0558540224760279 88 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.58868289208018 0.0711914958867174 no 270 0.056066001623537 98 5024745 SGTC_474 dl-dihydrosphingosine 5 µM 1.58868027517787 0.0711918309379937 no 271 0.0560662971780962 90 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.57938939044984 0.0723890258091554 no 272 0.0571233846958532 127 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_840 0245-0196 390 µM 1.57852991998624 0.0725005493752838 no 273 0.0572219600404901 94 3827528 SGTC_1926 methyl fluorone black 53.6 µM 1.57745960156613 0.0726396162014243 no 274 0.0573449053080888 110 72721 Reacts with homocysteine. SGTC_1077 5-fluorocytosine 377 nM 1.57392795902574 0.073099933047559 no 275 0.0577520526516259 105 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_651 3253-0966 34.4 µM 1.57016374220997 0.0735930178383535 no 276 0.058188511178886 90 781462 SGTC_441 propafenone 146 µM 1.56621082785639 0.0741135538323398 no 277 0.0586496343239349 90 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_380 3970-0968 6 µM 1.56547786751175 0.0742103814099338 no 278 0.0587354514712815 82 2891601 SGTC_1354 1498-1681 81 µM 1.56421201164646 0.0743778345211454 no 279 0.058883893643064 96 5754243 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.56234228292376 0.0746256982189165 no 280 0.0591036880485175 106 5393153 SGTC_1635 st007035 42.4 µM 1.5618162345124 0.0746955482096208 no 281 0.0591656430862098 104 3716403 SGTC_2446 5162541 200 µM 1.55784942590414 0.0752238782883722 no 282 0.059634473143073 80 1549321 SGTC_2570 licareol 100 µM 1.55778912235138 0.0752319319074859 no 283 0.0596416227118339 91 443158 SGTC_1673 st016611 27.3 µM 1.55428309463155 0.0757012975461957 no 284 0.06005845209338 103 5226799 SGTC_2966 9084041 48.03 µM 1.55399133489253 0.0757404568798304 no 285 0.0600932417765661 77 17741380 SGTC_2962 9082311 13.18 µM 1.54730951231398 0.0766415048464147 no 286 0.0608943145385616 107 16459453 SGTC_2602 kawain 100 µM 1.54643552088791 0.0767599635375512 no 287 0.060999710549176 94 5369129 SGTC_977 1348-1378 135 µM 1.54564235823401 0.076867587345092 no 288 0.0610954826686945 94 X977 SGTC_986 1493-0483 84 µM 1.54427807651961 0.077052974288469 no 289 0.0612604906575898 85 40079 SGTC_2267 7931562 200 µM 1.54363745701194 0.0771401427373358 no 290 0.061338092749667 84 934880 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.54288958991492 0.0772419990323984 no 291 0.0614287835236649 80 16623 A steroid. SGTC_2029 5175081 200 µM 1.5428426571093 0.0772483944851634 no 292 0.0614344783633165 84 1380876 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.53946924846487 0.0777091375125197 no 293 0.0618448898419256 70 364106 SGTC_1190 1486-1332 13 µM 1.53762014970822 0.0779625725522042 no 294 0.0620707588919847 85 4150046 SGTC_1520 flindersine 88 µM 1.53677215318978 0.0780790073830659 no 295 0.06217455744534 99 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_711 k292-0785 179 µM 1.5334226617673 0.0785402018064779 no 296 0.0625858743088087 91 4146315 SGTC_2842 9000675 19.48 µM 1.53165616466698 0.0787842625702628 no 297 0.0628036524711923 95 2989072 SGTC_3235 9132602 49.47 µM 1.5315863435287 0.0787939209109727 no 298 0.0628122723104654 108 4912240 SGTC_1160 4092-0570 10.5 µM 1.52519590462283 0.0796817125788573 no 299 0.0636051208902482 96 4994975 SGTC_2964 9083345 53.42 µM 1.52248124726821 0.0800611283338061 no 300 0.0639442703484329 111 17741579 SGTC_1689 st020265 53.493 µM 1.51044890540718 0.0817592936037806 no 301 0.0654644588211381 93 5758320 YPR016C TIF6 SGTC_3008 9078912 71.4286 µM 1.51028827803857 0.0817821457255089 no 302 0.0654849407305431 83 16648731 SGTC_414 piperonyl butoxide 100 µM 1.50864627393 0.0820160264622045 no 303 0.0656946010456514 100 5794 A potent inhibitor of cytochrome P450. SGTC_1547 harmine 94.2 µM 1.50185098460988 0.0829892815037233 no 304 0.0665677988308356 113 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2907 7721985 69.9 µM 1.50055217437383 0.0831762884032859 no 305 0.0667357145841278 90 3267881 SGTC_1064 honokiol 6.76 µM 1.4983670068392 0.08349163063442 no 306 0.0670189617694317 107 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_763 3453-1109 128 µM 1.49674577219522 0.0837261715012511 no 307 0.0672297106524567 76 1560353 SGTC_1197 1601-0112 267 µM 1.49669564915477 0.0837334305836714 no 308 0.0672362344445457 101 7350313 SGTC_1217 1183-1422 255 µM 1.4964079937365 0.0837750994973906 no 309 0.06727368385971 95 2849664 SGTC_2755 lomerizine 42.69 µM 1.49632297156447 0.0837874185396972 no 310 0.0672847558520634 75 3949 A calcium channel blocker. SGTC_2506 ethyl hematommate 54.16 µM 1.49461377054313 0.0840353569998626 no 311 0.067507635090747 62 3940691 An allergen. SGTC_2536 dehydroabietamide 32.04 µM 1.49016499988235 0.0846832826599827 no 312 0.0680904283576643 78 3983547 SGTC_1220 1838-0075 193 µM 1.49001326138562 0.0847054479714258 no 313 0.0681103745304046 86 5529645 SGTC_2228 7354201 200 µM 1.48899759083997 0.0848539248273977 no 314 0.0682440015684796 112 753451 SGTC_1734 st037168 69.4 µM 1.48756428402567 0.0850637861355373 no 315 0.068432919181036 98 708907 SGTC_466 geldanamycin 89.2 µM 1.48457968818534 0.085502031402876 no 316 0.0688275996748445 57 5288382 HSP90 inhibitor. SGTC_1769 st044406 64.4 µM 1.48236125564239 0.085828870460195 no 317 0.0691220986597487 127 670903 SGTC_652 0437-0092 114 µM 1.48151715666457 0.0859534758627184 no 318 0.069234408261272 92 3091274 SGTC_1614 st002383 48.6 µM 1.48095405514743 0.0860366758259984 no 319 0.0693094085489307 73 1947235 SGTC_2224 6650123 117.647 µM 1.48014584485767 0.0861561966440597 no 320 0.0694171645806531 91 2908370 SGTC_1550 gossypolone 36.6 µM 1.47994643475644 0.0861857051651169 no 321 0.0694437711112055 100 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_91 0417-1751 58.384 µM 1.47972409882114 0.0862186151426331 no 322 0.0694734458079445 106 6795624 SGTC_2486 5283202 22.39 µM 1.47872863690953 0.0863660778349288 no 323 0.0696064277113533 91 1377751 SGTC_805 3852-0218 479 µM 1.47845125610161 0.0864072012030914 no 324 0.0696435173880799 88 6615355 SGTC_1174 0739-0097 51.1 µM 1.47242571196662 0.0873041414437511 no 325 0.0704529770607424 104 728447 SGTC_384 k007-0144 5.16 µM 1.47087862412901 0.0875355527638903 no 326 0.0706619722344685 113 6824886 SGTC_2361 9034121 116 µM 1.47047115618264 0.0875965773602922 no 327 0.0707170960269785 133 6496917 SGTC_3144 9087057 49.47 µM 1.46542746523698 0.0883545779945316 no 328 0.0714021643158169 92 17249618 SGTC_3021 9087658 49.47 µM 1.46047315058676 0.089103894772843 no 329 0.0720800407044164 67 25237042 SGTC_3185 9108267 49.47 µM 1.45804101271746 0.0894734703714741 no 330 0.0724146193819063 96 4910486 SGTC_408 cantharidin 100 µM 1.45646149258181 0.0897140962994456 no 331 0.0726325435926487 101 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3351 9150312 21.596 µM 1.45465893668679 0.0899892871722407 no 332 0.0728818530006356 123 4904905 SGTC_2531 methyl deoxycholate 70.07 µM 1.45346343070708 0.0901721471841922 no 333 0.0730475630149328 104 16667744 Haematoxylin. SGTC_784 4579-0127 173 µM 1.45037486866176 0.0906458392716144 no 334 0.0734770056638726 110 1948547 SGTC_593 1203-0218 61.7 µM 1.44855293367095 0.0909261337928045 no 335 0.0737312366418039 114 3666956 SGTC_1993 st073995 70.8 µM 1.44745719374291 0.0910950166152132 no 336 0.0738844585631533 116 3098394 SGTC_3213 9129884 49.47 µM 1.44589854428336 0.0913356468409509 no 337 0.0741028301510363 104 17190742 SGTC_950 1165-0508 94.1 µM 1.44524262411252 0.0914370510472718 no 338 0.0741948738469728 92 6148369 SGTC_1616 st002734 56.1 µM 1.44437475364155 0.0915713506506332 no 339 0.0743167941897866 101 4026101 SGTC_1663 st014140 55.4 µM 1.44154264561709 0.0920106252176581 no 340 0.074715719226906 97 4207120 SGTC_1572 epiandrosterone 68.9 µM 1.44090467121972 0.0921097933224828 no 341 0.074805808114358 97 441302 A steroid. SGTC_3080 9117754 49.47 µM 1.43856490016008 0.0924741696383622 no 342 0.0751369185462263 113 9550191 SGTC_1847 st056231 15 µM 1.43706558815148 0.0927082199122433 no 343 0.0753496789886972 106 5393180 SGTC_1588 farnesol 29.9 µM 1.4366014073724 0.092780769646275 no 344 0.0754156417468675 101 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_467 ro 31-8220 72.8 µM 1.43552463557038 0.0929492267260449 no 345 0.0755688266622679 109 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1287 0971-0001 34.6 µM 1.43490689469585 0.0930459720797492 no 346 0.0756568153634043 115 4665869 SGTC_1388 3346-4487 254 µM 1.43472896013427 0.0930738524887604 no 347 0.0756821741701761 113 3345614 SGTC_216 k038-0035 28.382 µM 1.43453509669826 0.0931042358069773 no 348 0.0757098104919285 128 4444231 YPR107C YTH1 SGTC_824 1304-0008 100 µM 1.43385261142586 0.0932112568901117 no 349 0.0758071637724741 112 768245 SGTC_1226 3909-7979 35.4 µM 1.43335458113829 0.093289410784691 no 350 0.0758782655783555 125 6615510 SGTC_675 1309-0189 238 µM 1.42784438270569 0.0941573373691337 no 351 0.0766683274545538 98 4246530 SGTC_1027 k015-0025 8.67 µM 1.42699096149852 0.0942922931296772 no 352 0.0767912499592419 109 3598955 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.4248221067872 0.0946359068538453 no 353 0.0771043151580194 112 676296 Flavone; oxidizing agent. SGTC_990 3985-0011 41.3 µM 1.42336167168097 0.0948678044251505 no 354 0.0773156687224505 112 5399565 YGL099W LSG1 SGTC_2090 5301565 104.445 µM 1.42017097392765 0.0953759006642935 no 355 0.0777789558765365 115 2056344 SGTC_3159 9100096 49.47 µM 1.4181095224987 0.0957052358858026 no 356 0.0780793957708762 94 25236875 SGTC_34 0469-0683 81.75 µM 1.41627467588124 0.0959990720752297 no 357 0.0783475496670171 94 3690923 SGTC_3027 9089541 49.47 µM 1.41625983583473 0.0960014512928362 no 358 0.0783497213107666 114 9943819 SGTC_2440 5628896 157.78 µM 1.41578246768155 0.0960780080614377 no 359 0.0784196021523191 101 5522048 SGTC_291 SEC14.278 35.5 µM 1.41128214063549 0.0968019444921014 no 360 0.0790807191806708 103 1068044 SGTC_3226 9131256 49.47 µM 1.40945936606009 0.0970962985787887 no 361 0.0793496902659006 86 17178073 SGTC_2115 tiliquinol 12.7705 µM 1.405405705417 0.0977532653265514 no 362 0.0799503355683709 117 71208 A bioactive hydroxyquinoline. SGTC_2895 9054447 58.44 µM 1.40524004271143 0.0977801830121225 no 363 0.0799749553217792 108 2697450 SGTC_3284 9108171 64.8615 µM 1.40288039051534 0.0981641808907445 no 364 0.0803262546541578 105 8687505 SGTC_3321 9137793 26.8275 µM 1.40087054816215 0.098492122744189 no 365 0.0806263936780301 133 4904192 SGTC_2266 7929956 200 µM 1.38699734323046 0.10077768498781 no 366 0.0827212864806801 113 2967153 SGTC_386 1509-0011 3.07 µM 1.38684453522505 0.100803073132676 no 367 0.0827445868424867 105 3107280 SGTC_63 0099-0242 26.702 µM 1.38586796315064 0.100965434951207 no 368 0.0828936124621356 139 3898502 YLR359W ADE13 SGTC_1295 1013-0063 9.78 µM 1.38482578700666 0.101138914092572 no 369 0.0830528719352362 111 6826038 SGTC_2769 toremifene 3.73 µM 1.38256377258598 0.101516192975614 no 370 0.083399331831286 120 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2737 bleomycin 30.5 nM 1.3811192384638 0.101757660897706 no 371 0.0836211506051266 119 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_459 nigericin 15.3 µM 1.37867756967552 0.102166759789492 no 372 0.0839970941188877 115 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1888 azatryptophan 97.5 µM 1.37520495538049 0.10275065143829 no 373 0.0845339562299834 88 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.37151136589125 0.103374355663624 no 374 0.0851078014321583 103 16486 A toxic proline analog. SGTC_3252 9135871 49.47 µM 1.37034275856968 0.103572259347314 no 375 0.085289965728536 103 17682838 SGTC_3337 9144342 33.5465 µM 1.37022642757889 0.103591975040791 no 376 0.0853081155555742 120 17682949 SGTC_1162 k048-0130 20.1 µM 1.36468223330357 0.104534761292018 no 377 0.0861764730508111 113 6797406 SGTC_1994 st072947 40.9 µM 1.35767071018349 0.105735946807138 no 378 0.0872840973776983 107 5286565 YDL195W SEC31 SGTC_2528 xanthyletin 44.79 µM 1.3571398311717 0.105827299528658 no 379 0.0873683922543365 113 65188 An natural product with antifungal activity of unknown mechanism. SGTC_462 ag-879 158 µM 1.35645924754022 0.105944496586226 no 380 0.0874765466396136 130 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1283 0922-0125 16.4 µM 1.35261132045979 0.106608877267646 no 381 0.0880899169971168 106 3360884 SGTC_2388 9080168 200 µM 1.35137529677432 0.10682292516084 no 382 0.0882876214724782 111 15943073 SGTC_821 1114-0266 29.2 µM 1.35066692140608 0.106945737469828 no 383 0.0884010765084707 114 3123235 SGTC_2038 4100038 30.985 µM 1.35008736304914 0.107046292273939 no 384 0.0884939806871427 139 3596803 SGTC_1265 0819-1001 68.8 µM 1.34935532228491 0.107173400593065 no 385 0.0886114319936473 122 3106768 SGTC_454 lyso-paf C-16 6.67 µM 1.34770476647493 0.10746039506775 no 386 0.0888766792102949 112 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1280 0880-0253 10.1 µM 1.34333336553951 0.108223158322239 no 387 0.0895820264008571 121 6836607 SGTC_1230 0170-0365 3.77 µM 1.34297982052395 0.108285018092072 no 388 0.0896392540680687 138 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3114 9122766 49.47 µM 1.34056364170275 0.108708458189281 no 389 0.0900310842529064 96 17176985 SGTC_2360 9040895 200 µM 1.34030946666587 0.108753071992327 no 390 0.0900723775233018 108 4914414 SGTC_925 2064-1272 59.6 µM 1.33990696754043 0.10882374715348 no 391 0.0901377963037097 128 6815817 SGTC_420 mitomycin C 81.9 mM 1.33970369416762 0.108859452644278 no 392 0.0901708480381122 128 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_227 fluconazole 33.516 µM 1.33805785381339 0.109148858945085 no 393 0.0904387891110312 173 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2736 butenafine 14.65 µM 1.33494276507343 0.109698132114976 no 394 0.0909475398375905 117 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_668 1682-0499 62.6 µM 1.33380356898195 0.109899497453667 no 395 0.0911341205172542 120 682214 SGTC_1712 st032288 53.4 µM 1.33314624805205 0.110015806716586 no 396 0.0912419074239621 159 2883011 SGTC_292 k038-0015 474 µM 1.33241090273861 0.110146026593351 no 397 0.0913626006883355 121 46368540 SGTC_2665 lovastatin 100 µM 1.32914428035148 0.110725838492981 no 398 0.0919001868948966 118 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2154 5570129 200 µM 1.32810277746347 0.110911159945279 no 399 0.0920720780219641 116 673366 SGTC_769 0302-0231 76 µM 1.32772148766782 0.11097906087505 no 400 0.0921350661245054 147 571869 YER009W NTF2 SGTC_148 3253-0744 288.01 µM 1.32655087460146 0.111187712257886 no 401 0.0923286477319634 112 6893655 SGTC_2993 9054257 71.4286 µM 1.32460427164294 0.111535298556168 no 402 0.0926512191925763 145 6470217 YGL055W OLE1 SGTC_3030 9087619 49.47 µM 1.32307343548434 0.111809190997575 no 403 0.0929054789112758 138 25236973 SGTC_554 4483-2211 187 µM 1.3182396921799 0.112677185957969 no 404 0.0937117110942236 106 747107 SGTC_2832 7992762 51.95 µM 1.31811049612526 0.112700451527633 no 405 0.0937333306817119 119 2985177 SGTC_653 0203-0016 55.2 µM 1.31596272231199 0.113087724330497 no 406 0.0940932774094426 130 295302 SGTC_2645 abamectin 100 µM 1.31307339118338 0.113610206731528 no 407 0.0945791095479327 127 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_144 4161-2749 112.381 µM 1.31267692958578 0.113682033578411 no 408 0.0946459173626892 148 797501 YMR168C CEP3 SGTC_1366 1683-0113 21.9 µM 1.31174924763419 0.113850227956278 no 409 0.0948023771218861 123 708623 SGTC_512 prima-1 270 µM 1.30977449600848 0.114208852786715 no 410 0.0951360666991631 105 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2866 9034245 58.44 µM 1.30537001284615 0.115011625595808 no 411 0.0958834421286973 96 6462273 SGTC_1998 st075797 76.8 µM 1.30479074901472 0.115117501610057 no 412 0.0959820550319299 126 24208315 SGTC_1896 st058441 89 µM 1.30473703155705 0.115127323427494 no 413 0.0959912035792797 119 688759 SGTC_1415 3966-0071 78.1 µM 1.30430435621188 0.11520645646178 no 414 0.0960649153146732 113 2893185 SGTC_2777 climbazole 1.536 µM 1.30058998654097 0.115887377577554 no 415 0.0966994181916538 136 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1488 4013-0813 75.9 µM 1.30033227547393 0.115934727159785 no 416 0.0967435553029358 107 2910057 SGTC_2274 7947094 46.08 µM 1.29761016752629 0.116435702432773 no 417 0.0972106632597028 127 2971028 SGTC_362 0310-0100 9.03 µM 1.29746788602093 0.116461930009356 no 418 0.0972351238981516 105 790235 SGTC_49 0717-0965 32.132 µM 1.2970916935603 0.116531295938309 no 419 0.0972998196098883 125 5889349 YGL099W LSG1 SGTC_151 3013-0144 2.285 µM 1.29600218849038 0.116732354506275 no 420 0.097487365455068 152 906558 YHR107C CDC12 SGTC_3278 9139605 49.47 µM 1.29272709734914 0.117338224227783 no 421 0.0980527311849681 134 7958859 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.29214731245671 0.117445712119744 no 422 0.0981530668957695 114 4620898 SGTC_2850 9015429 58.44 µM 1.29088443175573 0.117680082275729 no 423 0.0983718772841391 131 6457570 SGTC_899 1083-0020 478 µM 1.28967682578034 0.117904503772626 no 424 0.0985814445157905 134 767123 SGTC_82 0054-0107 293.755 µM 1.2871506334714 0.11837495018982 no 425 0.0990208950254445 117 3104697 SGTC_159 3970-0959 50 µM 1.28648610046159 0.118498924636088 no 426 0.0991367333282307 153 6615653 SGTC_1779 st039427 55 µM 1.28472961092686 0.118827054865208 no 427 0.0994433935254305 121 1124498 SGTC_1483 3453-0561 55.9 µM 1.28271680308213 0.11920385645439 no 428 0.0997956554152007 137 4546991 SGTC_326 k292-0812 17.5 µM 1.28206970401725 0.119325173635525 no 429 0.0999090977502579 123 3579357 SGTC_1311 1190-0148 100 µM 1.27943373446691 0.119820261624418 no 430 0.100372180384153 143 1961333 SGTC_1278 0874-0585 172 µM 1.27885116638464 0.119929874741118 no 431 0.100474735957392 123 766306 SGTC_1426 4048-4480 71.7 µM 1.27746264099082 0.120191417754083 no 432 0.100719480890219 121 14224343 SGTC_1434 4073-0095 163 µM 1.27742263477511 0.120198959287307 no 433 0.100726538923602 135 24133745 SGTC_2694 st077685 81.9 µM 1.27664667262958 0.12034530111849 no 434 0.100863508176153 118 2838096 SGTC_1431 4049-0260 9.09 µM 1.2733526279726 0.120967935397335 no 435 0.101446469685943 143 3854841 SGTC_1097 itavastatin 7.23 µM 1.27174680808109 0.121272284940648 no 436 0.101731546846347 148 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_908 3448-7491 47.7 µM 1.27063870962999 0.12148261555522 no 437 0.101928604570409 122 1203031 SGTC_1575 cyproterone acetate 48 µM 1.26931403195669 0.121734391902136 no 438 0.102164541840221 142 9880 An androgen receptor antagonist and liver toxin. SGTC_2681 menadione 3.18 µM 1.26923738598909 0.121748970916718 no 439 0.102178205340307 137 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_579 4491-1009 110 µM 1.26703755517816 0.122167929035153 no 440 0.102570930881544 151 1271041 SGTC_2066 5222451 176 µM 1.26480880663854 0.122593425762186 no 441 0.102969936842079 163 2281147 SGTC_794 k038-0031 316 µM 1.26293057468621 0.12295281078699 no 442 0.103307065428462 127 6624242 SGTC_2924 9010168 62.78 µM 1.26113843208879 0.12329641132322 no 443 0.103629488047692 117 2993929 SGTC_1335 1486-0900 202 µM 1.25864565032346 0.123775460592134 no 444 0.104079175226053 110 X1335 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.25678373772445 0.124134121914728 no 445 0.104415978142792 126 6708784 An antioxidant flavonoid SGTC_1985 st071382 65.5 µM 1.25587647703422 0.12430915129444 no 446 0.104580379156123 147 6123237 SGTC_1314 1222-0010 41.1 µM 1.25356443393095 0.124755972470381 no 447 0.10500018266127 115 3526027 SGTC_2792 7535235 81.82 µM 1.24995137609251 0.125456470609697 no 448 0.105658655048984 139 1281891 SGTC_1512 0259-0544 12.2 µM 1.24914269246448 0.125613633106896 no 449 0.105806444016605 142 18476 SGTC_1029 k015-0030 64.7 µM 1.24537993603616 0.126346707212162 no 450 0.1064960624586 144 2208316 SGTC_2053 5265679 138 µM 1.24524383745203 0.126373278188819 no 451 0.106521066566466 156 764595 SGTC_2587 piperic acid 92.2 µM 1.24508480739775 0.126404331084846 no 452 0.10655028902605 109 5370536 SGTC_3269 9137823 49.47 µM 1.24159325952028 0.127087445820377 no 453 0.107193334988404 107 17682936 SGTC_2887 9044784 58.44 µM 1.23632755316127 0.128122522744992 no 454 0.108168416644663 157 6465546 SGTC_251 melphalan 456.522 µM 1.23426506877659 0.128529535669735 no 455 0.10855207391128 158 460612 A DNA alkylator. SGTC_2064 5220758 200 µM 1.23397110367135 0.128587620052462 no 456 0.10860683603675 153 788518 SGTC_3251 9135047 49.47 µM 1.23346184848105 0.128688286577861 no 457 0.108701751112075 111 17682963 SGTC_3167 9103034 49.47 µM 1.23335194850463 0.128710018120679 no 458 0.108722242113305 130 5127859 SGTC_2937 9044753 11.33 µM 1.2308481317589 0.12920581096033 no 459 0.109189834941781 120 6465530 YGL099W LSG1 SGTC_294 k038-0071 157 µM 1.23021924213469 0.129330548176007 no 460 0.109307508067672 150 24152826 SGTC_3228 9131799 49.47 µM 1.22912912866681 0.129546964574437 no 461 0.109511697726036 140 17015818 SGTC_1947 st076332 61.6 µM 1.22331118733275 0.130706221849772 no 462 0.110606091649657 149 24208416 SGTC_2131 toluylene red 5.2905 µM 1.22124515832762 0.131119609932701 no 463 0.110996605437804 125 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_398 bronopol 33.3 µM 1.21913142047611 0.131543477756468 no 464 0.11139715799219 156 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_795 0685-0265 78 µM 1.21460292162611 0.132454758620463 no 465 0.112258787011047 162 302754 SGTC_2364 9055074 200 µM 1.21023952032154 0.133336922820618 no 466 0.113093498697069 122 6470630 SGTC_1443 4112-3303 14 µM 1.2093704881893 0.133513099675479 no 467 0.113260270680022 156 704433 SGTC_2347 9049783 174.81 µM 1.20924913145647 0.133537714775921 no 468 0.113283573648907 149 6467988 YPL169C MEX67 SGTC_2656 pseudo-anisatin 100 µM 1.207774416106 0.133837084514873 no 469 0.113567022424829 138 6708809 A neurotoxin. SGTC_257 daunorubicin 18.5 µM 1.20530713883443 0.134338976864109 no 470 0.114042377361912 135 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1471 k673-0312 37 µM 1.20491496759421 0.134418871035926 no 471 0.114118064915256 142 24099884 SGTC_1460 k062-0059 9.15 µM 1.20325081728281 0.134758259079609 no 472 0.114439637620338 136 1373085 SGTC_1726 st035556 14.5795 µM 1.20211113635331 0.134991025392601 no 473 0.114660236127751 117 5919439 SGTC_55 0767-0285 6.563 µM 1.20009022364263 0.135404450544223 no 474 0.11505215099691 139 3116166 SGTC_2003 4023581 200 µM 1.19926392377074 0.13557373926702 no 475 0.115212669093469 122 16641307 SGTC_299 1273-0059 1.44 µM 1.19648220786942 0.136144710622399 no 476 0.115754218830704 151 2848077 SGTC_900 1112-0045 141 µM 1.19607370256103 0.136228698273137 no 477 0.115833899411773 138 56211 YIL048W NEO1 SGTC_1748 st037455 53.6035 µM 1.1939340185093 0.136669191017965 no 478 0.116251889572299 142 580690 SGTC_2565 isoliquiritigenin 100 µM 1.19382813245853 0.136691014841446 no 479 0.116272602312488 133 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2339 9000433 200 µM 1.19278497129416 0.136906144701857 no 480 0.116476798694093 123 2988954 SGTC_1281 0884-0031 11.8 µM 1.19107502787111 0.137259284565099 no 481 0.116812066126523 148 1548255 SGTC_640 3381-0960 37.1 µM 1.18965084835153 0.137553882551351 no 482 0.117091825734358 143 1745025 SGTC_3285 9112818 20.8695 µM 1.18890436501771 0.137708468293152 no 483 0.117238651138582 179 17017947 YPR165W RHO1 SGTC_314 1671-0008 2.74 µM 1.1874206175734 0.138016082514923 no 484 0.117530875735802 165 3913060 SGTC_2240 6690706 185.951 µM 1.1870580372391 0.138091324775778 no 485 0.117602364401854 118 805876 SGTC_263 alizarin 107.927 µM 1.18688084389803 0.138128105911259 no 486 0.117637312173202 180 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_26 0302-0163 425.158 µM 1.18648894054838 0.138209479477862 no 487 0.11771463322095 175 3100915 SGTC_1186 1319-0216 26 µM 1.1847654098722 0.138567735808904 no 488 0.118055106212434 151 4565136 SGTC_2101 5377231 179.231 µM 1.17895749205873 0.139779636134531 no 489 0.119207551367199 157 2844213 SGTC_1511 0906-3109 28.5 µM 1.17823933699944 0.139929987898392 no 490 0.119350602175441 153 2882180 SGTC_776 4476-4378 112 µM 1.17631778781187 0.140332820595068 no 491 0.119733955134005 148 2892008 SGTC_2727 riluzole 51.77 µM 1.17301229974128 0.141027622611564 no 492 0.12039543667275 150 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3074 9116018 49.47 µM 1.17219568335169 0.141199631292843 no 493 0.120559250546298 154 17027303 SGTC_1048 3161-0300 24.5 µM 1.17188348723824 0.14126542855278 no 494 0.120621918777049 131 2165101 SGTC_2900 5328528 85.29 µM 1.17176972789426 0.141289409203386 no 495 0.12064475979305 155 795359 SGTC_1200 1643-0193 18.4 µM 1.17138481470298 0.141370569980328 no 496 0.120722066649389 161 5403974 SGTC_1687 st020778 55.3625 µM 1.1700348016738 0.141655476377681 no 497 0.120993481995504 140 4259299 SGTC_1818 st052136 56.3 µM 1.16805961637806 0.142073019370411 no 498 0.121391359162297 156 674169 SGTC_1447 4239-0816 81.9 µM 1.16705401477846 0.142285917571444 no 499 0.121594278443668 156 1341554 SGTC_3263 9137018 49.47 µM 1.16297438391312 0.143151838934554 no 500 0.122419947851973 169 43844957 SGTC_2268 7933382 153.85 µM 1.16101727415875 0.14356850583283 no 501 0.122817437312018 141 935025 YOR257W CDC31 SGTC_1767 st044992 70.3 µM 1.15827166822759 0.144154421336327 no 502 0.123376594704793 140 9600693 SGTC_1619 st003326 88.7 µM 1.15800700452385 0.144210985953041 no 503 0.123430588983125 120 2849032 SGTC_2485 5633444 17.78 µM 1.15717702087113 0.144388469252621 no 504 0.123600022030442 158 5724239 SGTC_1868 st057644 42.7 µM 1.15653985321355 0.144524820716744 no 505 0.123730204043345 140 688665 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.15548241002752 0.144751300957533 no 506 0.123946465862406 139 2724 A muscle relaxant with antifungal properties. SGTC_226 1,3-diallylurea 8.28947 mM 1.15491851861777 0.14487217131511 no 507 0.124061897573815 138 74537 YKL182W FAS1 SGTC_573 3702-0553 84.7 µM 1.15379945035972 0.145112245264991 no 508 0.124291199790549 166 1222756 SGTC_2122 5258151 111.688 µM 1.15292647643039 0.145299710346968 no 509 0.124470281845204 130 2173356 SGTC_912 3474-0017 2.18 µM 1.15207522521089 0.145482667462622 no 510 0.124645081355411 145 3360550 SGTC_3224 9130643 49.47 µM 1.14724570866669 0.146523594578806 no 511 0.125640042645634 146 17644395 SGTC_1822 st052468 42 µM 1.14621268036752 0.14674689516084 no 512 0.125853581204916 154 2873678 SGTC_1244 0416-0015 52.5 µM 1.14576539953706 0.146843650693129 no 513 0.125946117660655 143 96201 SGTC_3205 9113483 49.47 µM 1.14410220999761 0.147203806245418 no 514 0.126290625636141 141 17018033 SGTC_3076 9116187 49.47 µM 1.1429074240953 0.147462896460109 no 515 0.126538514902256 129 27241210 SGTC_2728 chlorpromazine 9.18 µM 1.13222777654117 0.149792353190835 no 516 0.128769342583284 166 2726 A thorazine and dopamine antagonist. SGTC_733 4069-0007 56.1 µM 1.1318767066362 0.149869343388001 no 517 0.128843136455253 159 5717425 YNL287W SEC21 SGTC_2108 5365811 200 µM 1.13109962488045 0.150039852518501 no 518 0.129006581089382 143 780283 SGTC_1183 1254-0324 198 µM 1.12976830089613 0.150332275300119 no 519 0.129286934284132 136 5799357 SGTC_3173 9105693 49.47 µM 1.12972561789987 0.150341656817817 no 520 0.129295929546161 147 17096658 SGTC_904 1141-0088 396 µM 1.12928464686092 0.150438602969928 no 521 0.129388887729356 146 1378119 SGTC_1564 D-Arginine 115 µM 1.12812590017144 0.150693548401454 no 522 0.129633376149103 175 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1109 tnp00067 928.257 nM 1.12767460016797 0.150792920443987 no 523 0.129728684200939 129 676295 SGTC_2070 5230947 200 µM 1.12326555461875 0.151766045855069 no 524 0.130662364186387 175 2835538 SGTC_636 0kpi-0074 126 µM 1.12264677726283 0.151902950092094 no 525 0.130793770180215 148 616434 SGTC_1583 clindamycin 39.6 µM 1.12200219493753 0.152045650890313 no 526 0.130930753325975 164 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_891 0929-0073 133 µM 1.12109572418927 0.152246480430552 no 527 0.131123559268141 172 5603632 SGTC_2256 7954252 200 µM 1.11797023208363 0.152940286384258 no 528 0.131789853624178 153 2972920 SGTC_16 erodoxin 22.806 µM 1.11752128209414 0.153040117539767 no 529 0.131885752588253 191 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1772 st048439 82.2 µM 1.11749080965543 0.153046895135281 no 530 0.13189226346557 154 2927068 YDL195W SEC31 SGTC_949 1165-0505 146 µM 1.11456564338874 0.153698428818378 no 531 0.132518299952039 151 6244267 SGTC_1380 2291-0730 164 µM 1.1139782389059 0.153829484778568 no 532 0.132644261179529 157 2999191 SGTC_2696 st077691 74.316 µM 1.11276858841035 0.154099603126296 no 533 0.132903914680207 163 757133 SGTC_307 1501-1223 22.3 µM 1.10944681949976 0.154842976402567 no 534 0.13361873709016 152 2830329 SGTC_2302 7771753 200 µM 1.1081927691605 0.155124233232753 no 535 0.133889286482218 162 2203047 SGTC_718 1130-0073 349 µM 1.10657706516917 0.155487098202091 no 536 0.134238413869676 156 6740020 SGTC_2386 9075165 157.42 µM 1.10544546972452 0.155741572213731 no 537 0.134483305265688 164 16452277 SGTC_729 4092-0585 94.1 µM 1.10434331369002 0.155989689733688 no 538 0.134722120277088 150 2169061 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.10051118040536 0.156854406796723 no 539 0.135554730490473 157 97141 SGTC_2715 st079500 56.4 µM 1.1000125994514 0.156967142528447 no 540 0.135663316147487 170 28246688 SGTC_1590 st077108 57.8 µM 1.09781720989006 0.157464183019819 no 541 0.136142157487621 148 5489485 SGTC_1750 st081859 2.357 µM 1.09694699933472 0.157661486344332 no 542 0.136332280810896 193 5291695 SGTC_1872 amphotericin b 148 nM 1.09614364344984 0.157843775787405 no 543 0.136507958931635 152 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_121 0557-0495 61.343 µM 1.09168801922649 0.15885731298984 no 544 0.137485126503418 193 3104427 SGTC_1768 st044301 37.178 µM 1.0896027052 0.159333129129277 no 545 0.137944095463734 205 3931349 SGTC_1194 1488-0194 225 µM 1.08834636726537 0.159620243822835 no 546 0.138221114181151 161 1391452 SGTC_956 1185-0240 191 µM 1.08738772050323 0.159839553864696 no 547 0.138432747846953 161 1416193 SGTC_1164 k060-0068 93.7 µM 1.08542294605461 0.160289651865629 no 548 0.138867187025686 160 5963676 SGTC_1898 st060199 18.6 µM 1.08313083419019 0.160815783426885 no 549 0.139375177248583 147 688866 SGTC_1931 st074438 57.1 µM 1.08050433330301 0.161420055359529 no 550 0.13995882909501 204 2787313 SGTC_1011 4112-3381 17.4 µM 1.07777175167275 0.16205030254334 no 551 0.140567814409972 170 2877139 SGTC_2892 9047358 58.44 µM 1.07655164272075 0.16233222737343 no 552 0.14084030886202 151 6466771 SGTC_1345 1488-0192 31.4 µM 1.07583413837122 0.162498166716073 no 553 0.141000720766645 154 658348 SGTC_3081 9117243 49.47 µM 1.07550301701756 0.162574783336744 no 554 0.141074791090074 198 45595589 SGTC_2825 7998094 58.44 µM 1.07484074343494 0.162728094225841 no 555 0.141223017799326 155 2987815 SGTC_178 4092-0806 87.505 µM 1.07424654882264 0.162865725399574 no 556 0.141356097252372 179 2169044 SGTC_2594 a-mangostin 100 µM 1.07414480291764 0.162889300027808 no 557 0.141378893407106 173 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_305 1682-2595 20.8 µM 1.07072078662291 0.163683941659162 no 558 0.142147496718678 173 226033 SGTC_2172 5754775 163.918 µM 1.06879083800828 0.164132949000065 no 559 0.142581964328999 192 2263357 SGTC_1376 2910-0861 41.3 µM 1.06496953376505 0.165024339483205 no 560 0.143444858413087 180 1112859 SGTC_2207 7258803 200 µM 1.06434077060842 0.165171309957329 no 561 0.143587177384877 173 3666799 SGTC_580 1123-0028 41 µM 1.06310728127863 0.165459878423847 no 562 0.143866651411152 178 1677248 YPR107C YTH1 SGTC_2382 9035899 200 µM 1.06219240016992 0.165674120666249 no 563 0.144074174633907 190 6462679 SGTC_3217 9129673 49.47 µM 1.06206893665888 0.165703046459133 no 564 0.144102195412954 172 17248312 SGTC_1653 st012112 65 µM 1.06140689742425 0.165858208791484 no 565 0.144252511840305 156 720429 SGTC_679 0422-0091 41.4 µM 1.06131171614857 0.165880524174494 no 566 0.144274131496638 194 627384 YHR062C RPP1 SGTC_2511 berberine 10.47 µM 1.06089201843089 0.16597894603386 no 567 0.144369488484297 183 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2056 5235370 200 µM 1.06035095773922 0.166105883976103 no 568 0.144492482285159 154 5511916 SGTC_1476 4112-3294 3.34 µM 1.05778232055173 0.166709365885431 no 569 0.145077347364576 180 704369 SGTC_2898 9056270 58.44 µM 1.05605852799604 0.167115150231208 no 570 0.145470738041253 121 19154699 SGTC_708 3448-5400 146 µM 1.05501787405413 0.167360430341752 no 571 0.145708575051902 200 3462195 SGTC_1838 st055369 84.5 µM 1.05421751768326 0.167549230528353 no 572 0.145891670816473 153 676036 SGTC_3324 9138759 60.749 µM 1.05094724099561 0.168322097938842 no 573 0.146641410874018 158 45595710 SGTC_1674 st016616 23.6 µM 1.04907372532295 0.168765899016509 no 574 0.147072093933198 161 625830 SGTC_311 1315-0136 58 µM 1.0475336821517 0.169131269214237 no 575 0.147426752973193 156 6759207 SGTC_3302 9125395 16.351 µM 1.04587509118626 0.169525332132833 no 576 0.147809353007288 161 17599668 SGTC_1093 fluphenazine 7.97 µM 1.04069759490964 0.170759234286206 no 577 0.149007959905117 185 6602611 An atypical antipsychotic. SGTC_1016 4226-1401 38 µM 1.03924151095107 0.171107281556858 no 578 0.149346214560274 181 2901613 SGTC_2222 6885208 172.143 µM 1.03664723780933 0.171728513243544 no 579 0.149950144914172 171 609514 SGTC_369 0957-0393 4.5 µM 1.03368104743605 0.17244056821007 no 580 0.15064264807178 170 6997992 SGTC_3264 9137442 49.47 µM 1.03326654754568 0.172540221591643 no 581 0.150739588837794 171 17015726 SGTC_1677 st019204 53.9 µM 1.03323930742467 0.172546771902498 no 582 0.150745961049299 158 3945625 SGTC_868 0527-0199 213 µM 1.03031758338179 0.173250266451936 no 583 0.151430473788993 168 2849450 SGTC_2508 celastrol 40.54 µM 1.02959218604794 0.173425210699785 no 584 0.151600742439583 143 122724 Celastrol is a natural product and antioxidant. SGTC_1776 st049249 45.9 µM 1.0292730781198 0.173502205635961 no 585 0.151675685233395 191 1822314 SGTC_3133 9127736 49.47 µM 1.02373115779059 0.174842838628046 no 586 0.15298113718901 162 27243420 SGTC_2453 5731132 22.18 µM 1.02267625127016 0.17509877149911 no 587 0.153230471845043 198 1362040 SGTC_528 3492-0019 172 µM 1.02260639427466 0.17511572802281 no 588 0.153246992543727 198 2869262 SGTC_661 1304-0007 33.6 µM 1.02145334547018 0.175395760263806 no 589 0.153519851164777 183 3117130 SGTC_566 0958-0068 16.5 µM 1.01929355055361 0.175921056746619 no 590 0.154031812465794 192 6815365 SGTC_923 1900-2434 73.3 µM 1.01837840193688 0.176143935643452 no 591 0.154249081107832 202 5910570 SGTC_3075 9116269 49.47 µM 1.01763071906443 0.176326161880256 no 592 0.154426741487042 171 17015205 YNL244C SUI1 SGTC_2133 5320837 200 µM 1.0172919300298 0.176408771238146 no 593 0.154507287232567 141 2841355 SGTC_3051 9093778 49.47 µM 1.0172686091448 0.176414458637224 no 594 0.154512832701604 203 17217378 SGTC_1519 esterone 74 µM 1.01720787458174 0.176429270870724 no 595 0.154527275379848 175 698 A steroid. SGTC_2293 7624732 200 µM 1.01556470651314 0.176830313051003 no 596 0.154918359364429 169 894453 SGTC_1123 mangostin 811.285 nM 1.01552904153363 0.176839024059803 no 597 0.154926855088457 119 5281650 An antioxidant. SGTC_126 0417-1624 672.48 µM 1.01540344154623 0.176869703444142 no 598 0.154956776603153 226 41912 YDL195W SEC31 SGTC_2654 protoveratrine a 100 µM 1.01399871741184 0.177213054241263 no 599 0.155291682151133 198 5702278 A heart drug and vasodilator. SGTC_706 4262-0057 46.9 µM 1.01346497487809 0.177343624968491 no 600 0.155419058860999 173 883298 SGTC_826 1683-5028 118 µM 1.01310153696763 0.177432568418047 no 601 0.155505832116746 158 722377 SGTC_2465 5809242 33.21 µM 1.0128986789556 0.177482225706536 no 602 0.155554279733322 202 2731748 SGTC_1323 1348-1351 11.2 µM 1.01265213038395 0.177542589745921 no 603 0.155613175161998 179 6989654 SGTC_228 caffeine 993.056 µM 1.01145399793592 0.177836120517114 no 604 0.155899593967928 139 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_819 1013-0258 27.7 µM 1.00773695486092 0.178748706307675 no 605 0.156790379526759 193 5753198 SGTC_64 000l-0018 272.079 µM 1.00663550547307 0.179019692723159 no 606 0.157054982802929 211 6811119 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.00428710178226 0.179598326264968 no 607 0.157620124419524 176 23847180 SGTC_1428 4049-0204 61.7 µM 1.00363757248685 0.179758573923795 no 608 0.157776668748075 197 X1428 SGTC_2726 cimetidine 79.27 µM 1.00257477682019 0.180020973651999 no 609 0.158033035387432 203 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_66 0109-0187 42.4 µM 0.999035544866935 0.180896527783065 no 610 0.158888736376156 142 759417 SGTC_1391 3442-0225 151 µM 0.998103368733571 0.181127577804418 no 611 0.159114618382654 168 5227075 SGTC_3120 9124077 49.47 µM 0.996569402362955 0.181508190299275 no 612 0.159486782001178 192 18774327 YGL155W CDC43 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.995976471866368 0.181655444107589 no 613 0.159630788549035 171 61125 An anti-inflammatory. SGTC_1299 1079-1439 3.74 µM 0.995954145219512 0.181660990372247 no 614 0.159636212740829 189 323161 SGTC_767 0929-0023 86 µM 0.995140921262992 0.181863079275617 no 615 0.159833865265275 201 1204563 SGTC_1970 st070122 35.8 µM 0.992760308818589 0.182455477411365 no 616 0.160413388417771 206 102928 SGTC_3280 9140961 49.47 µM 0.991248235936992 0.182832371021086 no 617 0.160782191181229 197 4901226 SGTC_2521 angolensin 13.4 µM 0.990218925890458 0.183089210764745 no 618 0.161033561933718 168 821428 A flavenoid. SGTC_3190 9110366 49.47 µM 0.989580394006771 0.183248654218177 no 619 0.161189628466356 164 17123768 SGTC_2134 5324836 1.464 µM 0.988474171799403 0.183525086324185 no 620 0.161460238841225 185 699272 SGTC_687 k029-0044 34.9 µM 0.988087724212379 0.183621716320725 no 621 0.161554843630384 147 5829338 SGTC_1688 st021091 57.6 µM 0.987189337188223 0.183846477647418 no 622 0.161774914029764 195 3656366 SGTC_1745 st081495 74 µM 0.987031235171051 0.183886049837649 no 623 0.16181366317167 195 13842402 YBL026W LSM2 SGTC_577 r071-0003 38.6 µM 0.986863334804704 0.183928080316158 no 624 0.161854820407052 200 4568517 YMR134W ERG29 SGTC_3181 9108277 49.47 µM 0.984728360544405 0.184463049743302 no 625 0.16237875906072 188 17097298 SGTC_2624 nerol 100 µM 0.980471514438022 0.185532590676116 no 626 0.163426711976964 198 637566 A natural product oil. SGTC_3254 9136651 49.47 µM 0.980096596765216 0.185626973530781 no 627 0.163519219457732 205 16454030 SGTC_2669 eugenol 100 µM 0.978892258289652 0.18593035867273 no 628 0.163816608893018 150 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2054 5233173 129 µM 0.978306891367892 0.186077929545092 no 629 0.163961281277621 129 6889 SGTC_1082 camptothecin 424.86 nM 0.974577573384304 0.187019793619295 no 630 0.164884921266161 223 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_680 0417-1641 114 µM 0.972410443885144 0.187568469033845 no 631 0.165423199141392 179 2835990 SGTC_721 1187-1332 279 µM 0.972022112628994 0.18766689200332 no 632 0.165519773952143 192 25730 SGTC_1936 st074407 74.3 µM 0.971162125111237 0.187884970292487 no 633 0.165733775600426 210 809813 SGTC_992 3909-8734 162 µM 0.967773487900389 0.188745793488674 no 634 0.166578753642197 177 4288319 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.967534120445034 0.188806692327837 no 635 0.166638546389175 190 688664 SGTC_3025 9087895 49.47 µM 0.965832571804017 0.189239941912629 no 636 0.16706398352437 194 17173641 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.964343258840511 0.189619653790044 no 637 0.167436929776311 210 5357218 A potent inhibitor of glutathione S-transferases. SGTC_940 3232-1287 54.8 µM 0.963837859095082 0.189748615811409 no 638 0.167563611249947 181 1585493 YIL048W NEO1 SGTC_547 1120-0019 610 nM 0.961217656783692 0.190418072892768 no 639 0.168221370126539 191 3676939 SGTC_704 1310-0270 142 µM 0.959570094964787 0.190839763865565 no 640 0.168635812959972 200 5718033 SGTC_1155 4088-0394 48.2 µM 0.956221637559097 0.191698560319637 no 641 0.16948013520264 188 2326248 SGTC_926 2268-1401 59.4 µM 0.952490185163896 0.192658368835223 no 642 0.170424220605521 221 2931578 SGTC_796 1234-0020 70.7 µM 0.951535291263479 0.192904458884987 no 643 0.170666356126061 184 46495034 SGTC_1835 st008666 49.2 µM 0.950497505956641 0.193172128865393 no 644 0.170929760284344 164 690455 SGTC_2677 mitomycin C 100 µM 0.948561537875691 0.193672067544218 no 645 0.171421830329973 213 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_834 0312-0008 75.7 µM 0.94696121108283 0.194085926259945 no 646 0.171829272405801 185 6385573 YIL048W NEO1 SGTC_1705 st027868 56.3335 µM 0.946244528182134 0.19427144135545 no 647 0.17201193970344 185 292948 SGTC_975 1335-0046 28.5 µM 0.944422309337607 0.194743613172139 no 648 0.172476942769216 202 16486740 SGTC_2618 avocadyne 43.43 µM 0.944411898736555 0.194746312762381 no 649 0.172479601700456 185 3015189 SGTC_1789 tunicamycin 25 nM 0.94346784573254 0.194991211337507 no 650 0.172720827285797 201 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1461 k072-0203 53.8 µM 0.942918464578393 0.195133813488653 no 651 0.172861304777131 186 5418714 SGTC_2068 5226020 147 µM 0.942716484225426 0.195186257197909 no 652 0.172912969721955 199 1810509 SGTC_3246 9135460 32.98 µM 0.942555847727823 0.195227972189843 no 653 0.172954066265918 196 41446951 SGTC_662 k832-1615 104 µM 0.941223577688184 0.195574152339718 no 654 0.173295148261971 195 5878478 SGTC_168 3970-0862 530.542 µM 0.939994089702264 0.195893955844833 no 655 0.173610296164546 235 3135186 SGTC_1982 st072467 71.9 µM 0.938281128761922 0.196340044688469 no 656 0.174049977586648 199 3163533 SGTC_2036 5160441 105 µM 0.936881002380936 0.196705122199011 no 657 0.174409886187726 220 134534 YIL048W NEO1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.936614369245369 0.196774692328583 no 658 0.174478478951338 188 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1051 3253-3903 78 µM 0.936197120847229 0.196883591011428 no 659 0.174585852657409 225 5509239 SGTC_2686 alizarin 95.37 µM 0.935531229221738 0.197057459264026 no 660 0.174757298515458 175 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_520 3584-0023 682 µM 0.934357444938655 0.197364167483425 no 661 0.17505977067574 195 1340790 SGTC_1891 st059073 26.2 µM 0.933973921935907 0.197464444062252 no 662 0.175158672561328 213 688754 SGTC_1105 epirubicin 18.1 µM 0.932414600925728 0.197872463945623 no 663 0.175561150966848 214 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_690 glyoxal 20.3 µM 0.931859528749238 0.198017829793929 no 664 0.175704562716973 206 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1694 st024011 44.9 µM 0.930040848511343 0.198494569039869 no 665 0.176174967561174 210 2787533 SGTC_2880 9042983 58.44 µM 0.928475543513561 0.198905443765657 no 666 0.176580474111117 215 6464714 SGTC_100 0086-0128 49.5915 µM 0.926920598729385 0.199314106167188 no 667 0.176983880681373 215 93297 SGTC_47 0149-0135 24.25 µM 0.92476201927484 0.199882250013049 no 668 0.17754485548923 215 5239155 SGTC_1846 st056244 14.8 µM 0.919935053618421 0.201156239282975 no 669 0.178803349721165 198 5393182 SGTC_2136 5328288 199.296 µM 0.919505895767469 0.201269742871374 no 670 0.178915511624394 176 262395 SGTC_511 blebbistatin 171 µM 0.917981397329282 0.201673252282031 no 671 0.179314302536454 202 3476986 A myosin inhibitor. SGTC_352 k048-0007 5.11 µM 0.917556521336814 0.201785796179857 no 672 0.179425544633214 226 6811911 SGTC_2270 7924575 90.91 µM 0.916832709796933 0.201977610643887 no 673 0.179615154672149 201 1262135 SGTC_1384 3089-0840 101 µM 0.915578082631523 0.20231035291058 no 674 0.179944115612149 173 1069836 SGTC_504 lovastatin 124 µM 0.914830178006933 0.202508862126008 no 675 0.180140394712074 201 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1199 1638-0010 4.46 µM 0.913877076510447 0.202762003478541 no 676 0.180390720089871 211 3111136 SGTC_951 1171-0579 82.7 µM 0.913337645147101 0.202905358834799 no 677 0.180532494596481 207 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2232 chlorophetanol 41.5365 µM 0.911778951765433 0.203319925907014 no 678 0.18094254631696 203 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2425 5628681 7.85 µM 0.911101128122057 0.203500364848428 no 679 0.181121046054604 204 5714958 SGTC_2149 5554786 194.827 µM 0.909647342636967 0.20388768943447 no 680 0.181504261342398 190 745063 YPR165W RHO1 SGTC_1853 st056710 91.2 µM 0.907471151298686 0.204468301254024 no 681 0.182078849200362 207 269167 SGTC_2682 pyrogallin 40.03 µM 0.901107870295159 0.206171672487548 no 682 0.183765484377904 193 822798 An ATP competetive kinase inhibitor. SGTC_1408 3909-7976 48.8 µM 0.900602715287924 0.206307255687002 no 683 0.183899795197439 224 24152374 SGTC_3260 9137109 49.47 µM 0.900593635761435 0.206309693107976 no 684 0.183902209824797 205 17478346 SGTC_2725 haloperidol 53.21 µM 0.900589241126906 0.206310872864436 no 685 0.183903378549748 221 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_859 0439-0102 54.6 µM 0.899921679401709 0.206490128793759 no 686 0.184080966037213 225 610143 SGTC_754 3474-0146 171 µM 0.899816164459102 0.206518470464678 no 687 0.184109045319166 205 24762078 SGTC_1327 1436-0082 2.18 µM 0.89942510901932 0.206623529374334 no 688 0.184213134928901 210 15992205 SGTC_1766 st045414 44.774 µM 0.899086725765959 0.206714463188757 no 689 0.184303234013272 214 253960 SGTC_428 3448-4153 16.5 µM 0.898082426565667 0.206984488249451 no 690 0.184570803582006 193 3834874 SGTC_1303 1160-0052 261 µM 0.894763717421875 0.207878269939372 no 691 0.1854567047438 204 3562476 SGTC_142 0335-0849 62.6745 µM 0.894148121062581 0.208044310158414 no 692 0.185621322680833 213 3889043 YPR107C YTH1 SGTC_1185 1319-0113 81.3 µM 0.893009449359985 0.208351641836728 no 693 0.185926056180207 216 4672763 SGTC_1285 0929-0069 65.5 µM 0.892832405812146 0.208399450585839 no 694 0.185973464764256 195 1206237 SGTC_790 1575-0012 79.1 µM 0.89257363864464 0.20846933957786 no 695 0.186042770717888 224 378741 YLR208W SEC13 SGTC_235 0330-0087 5 mM 0.891802332819044 0.208677739280266 no 696 0.186249445553691 201 46494818 YHR062C RPP1 SGTC_2409 alverine citrate 63.97 µM 0.891130945098437 0.208859241958333 no 697 0.186429462658644 166 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3098 9119039 49.47 µM 0.891081773939919 0.208872538523337 no 698 0.186442651003016 202 17161528 SGTC_1196 1588-0294 184 µM 0.889326010312917 0.209347648175716 no 699 0.186913948306149 206 6144269 SGTC_1624 st003710 6.25 µM 0.888925028821521 0.209456242913719 no 700 0.187021686552532 206 24207033 SGTC_1912 st060209 90.8 µM 0.88881512700829 0.209486012563551 no 701 0.18705122237416 211 688787 SGTC_2823 7987624 58.44 µM 0.887117788227915 0.209946095146814 no 702 0.187507744015796 229 2239440 SGTC_1433 4060-0023 7.6 µM 0.885855773542195 0.210288562862327 no 703 0.187847625413387 221 3840627 SGTC_1044 1222-0021 1.78 µM 0.885770861790417 0.210311616785985 no 704 0.187870507202356 225 4306703 SGTC_2323 6148992 148.28 µM 0.885768784724904 0.210312180737235 no 705 0.187871066945911 197 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1770 st043884 66.3 µM 0.885048754677927 0.210507732090522 no 706 0.188065168221205 243 670149 SGTC_1506 4226-2149 212 µM 0.884785728719856 0.21057919332649 no 707 0.188136103999102 201 991114 SGTC_1137 ixabepilone 100 µM 0.884435825205405 0.210674280292583 no 708 0.188230495477306 202 154225 A novel microtubule stabilizer. SGTC_1474 0330-0125 5.35 µM 0.88290373816552 0.211090924465689 no 709 0.188644141862611 206 X1474 SGTC_338 4055-0136 114 µM 0.881726236869135 0.211411468607497 no 710 0.188962434598441 192 2900563 SGTC_1919 st067113 52.3 µM 0.880377621187976 0.21177894418853 no 711 0.189327387797272 228 1268243 SGTC_2152 5568786 200 µM 0.875229592959783 0.213185129400566 no 712 0.190724497214444 226 5399883 SGTC_3045 9092950 49.47 µM 0.873317833914406 0.213708710271764 no 713 0.19124493129377 218 44120432 SGTC_778 3456-2434 196 µM 0.872054978788031 0.214054983743398 no 714 0.191589192633979 201 5539063 SGTC_2150 5556613 200 µM 0.871463045412002 0.214217403555388 no 715 0.191750687550217 221 743190 SGTC_1849 st056239 19.2 µM 0.869514187170399 0.214752654545088 no 716 0.19228297580551 227 5393181 SGTC_2448 5185112 27.17 µM 0.868422206080057 0.215052904895691 no 717 0.192581621359151 194 5718189 SGTC_364 0083-0097 67.7 µM 0.867933025875558 0.21518748855278 no 718 0.192715498994784 214 5207356 SGTC_1617 st002906 78 µM 0.866398823478316 0.215609896532964 no 719 0.1931357444619 218 5150859 SGTC_2088 5278280 127.392 µM 0.865778106230234 0.215780933529972 no 720 0.193305928854138 218 791502 SGTC_363 0455-0021 3.06 µM 0.864217755915276 0.216211231089286 no 721 0.193734139983467 224 4597466 SGTC_3178 9107506 49.47 µM 0.863917682751094 0.216294039143636 no 722 0.193816556122482 218 8897194 SGTC_2867 9039098 71.43 µM 0.862300018479777 0.216740765206741 no 723 0.194261221293812 213 6463460 SGTC_2081 5214970 32.255 µM 0.860438551261669 0.217255478311698 no 724 0.19477367131661 188 2063512 SGTC_2178 5812956 200 µM 0.860109478287254 0.21734654344688 no 725 0.194864348458661 226 5403383 SGTC_1477 0139-0234 16 µM 0.85771967779727 0.218008539478337 no 726 0.195523635784746 220 620880 SGTC_3046 9092212 49.47 µM 0.855373698722544 0.218659525815403 no 727 0.19617214966085 233 25236637 SGTC_1394 3474-0001 65.7 µM 0.854810581313863 0.218815951773242 no 728 0.196328009685544 181 5017666 YIL048W NEO1 SGTC_1581 himbacine 57.9 µM 0.854196185599621 0.218986695539818 no 729 0.196498148158566 221 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2470 5664817 21.68 µM 0.854153245800386 0.218998631597794 no 730 0.196510042388003 221 2859561 SGTC_1255 0566-0045 221 µM 0.85256585232296 0.219440144920196 no 731 0.196950052982909 218 2788469 SGTC_1952 st077036 64.1 µM 0.852452895978151 0.219471581769762 no 732 0.19698138613675 202 2937007 SGTC_232 clozapine 119 µM 0.850099489842758 0.220127145834507 no 733 0.197634887619507 215 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_548 1436-0017 110 µM 0.849870636035562 0.220190955142924 no 734 0.197698506326725 205 9677137 SGTC_3123 9126162 49.47 µM 0.848425912912212 0.220594019442619 no 735 0.198100408222536 221 25239884 SGTC_536 3852-0578 10.6 µM 0.847943000025181 0.220728841844596 no 736 0.198234857809039 219 2869208 SGTC_1662 st014054 52 µM 0.847372000643312 0.220888317615505 no 737 0.198393902934701 227 2838777 SGTC_2296 7971656 126.45 µM 0.847290311547555 0.220911138149057 no 738 0.198416662760349 213 666570 SGTC_2205 7238770 200 µM 0.846929547707922 0.221011936692095 no 739 0.198517195898827 209 279867 SGTC_3000 9075062 71.4286 µM 0.843151490727312 0.222069117665814 no 740 0.199571862193343 217 17057871 SGTC_191 3914-0123 66.505 µM 0.842692432902837 0.22219776823677 no 741 0.199700240179448 237 3144412 SGTC_2362 9071156 126 µM 0.840764877599841 0.222738428005335 no 742 0.20023983345035 218 653133 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.840507967637751 0.222810545232032 no 743 0.20031181806062 226 6708514 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.840441125306374 0.222829310731911 no 744 0.200330549424247 206 2374 Ca(2+)-ATPase inhibitor. SGTC_2012 4023501 200 µM 0.839381732834362 0.223126847701202 no 745 0.200627565638829 242 3477460 SGTC_3242 9133940 49.47 µM 0.838250715679869 0.223444750422374 no 746 0.200944954516507 215 17248444 SGTC_2017 5132927 60.65 µM 0.836983191092335 0.223801328236306 no 747 0.201301008194458 201 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_514 4466-0038 2.65 nM 0.836826247289262 0.223845501887015 no 748 0.201345120752777 228 5722064 SGTC_457 grayanotoxin iii 135 µM 0.83481297552095 0.224412599868563 no 749 0.201911509473173 237 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2237 6667747 47.222 µM 0.833176697146464 0.224874106482131 no 750 0.202372541446735 229 729940 YDL015C TSC13 SGTC_1696 st025591 34.7925 µM 0.831784524164417 0.22526718729279 no 751 0.202765290379711 210 2787147 SGTC_2471 5466956 24.79 µM 0.830339989009143 0.225675463649102 no 752 0.203173292372908 230 724419 SGTC_2092 5303694 80.6725 µM 0.830314254896284 0.225682740806509 no 753 0.203180565289279 228 1963699 SGTC_349 k015-0014 24 µM 0.829229832390423 0.225989517188367 no 754 0.203487183543101 226 2196908 SGTC_3283 9109332 35.8195 µM 0.828994863638512 0.226056019447724 no 755 0.203553656842748 201 17027281 SGTC_1966 st070145 16.1 µM 0.828854799135604 0.226095666601329 no 756 0.203593287632299 238 3748532 SGTC_2560 caryophyllene 100 µM 0.827461843082087 0.226490175495458 no 757 0.203987670334868 250 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_233 rapamycin 362 pM 0.825566200394223 0.227027677650258 no 758 0.204525107534119 246 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_343 4130-2827 29.8 µM 0.825460158121817 0.227057766754624 no 759 0.204555196642936 214 1118244 SGTC_756 0508-1999 28.3 µM 0.825340363886148 0.227091760632486 no 760 0.204589190989709 236 6753853 SGTC_2948 9070189 9.45 µM 0.824790962279859 0.227247700468207 no 761 0.204745139280959 210 6473636 YDL196W YDL196W SGTC_930 2810-3379 265 µM 0.823966056918069 0.227481951413139 no 762 0.204979422368723 229 1015764 SGTC_905 2-aminofluorene 215 µM 0.823247377558495 0.22768614783984 no 763 0.205183665836656 237 1539 An established DNA mutagen. YPR165W RHO1 SGTC_616 4092-0450 108 µM 0.822249300881837 0.22796989974557 no 764 0.205467512490823 256 787165 SGTC_952 1185-0122 232 µM 0.821870095353521 0.22807775950987 no 765 0.205575417224297 226 678600 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.820039138983864 0.228598953336911 no 766 0.206096897731399 208 4174840 SGTC_3182 9108849 49.47 µM 0.818134377695966 0.229141865403317 no 767 0.206640230426092 233 17133045 SGTC_1128 3448-9350 235 µM 0.817913586020839 0.229204844155859 no 768 0.206703266014303 213 619386 SGTC_1978 st071761 42 µM 0.817427096231461 0.229343645051717 no 769 0.206842198066936 220 5147680 SGTC_1307 1187-1599 12.2 µM 0.817072657500149 0.229444799989052 no 770 0.206943453694386 245 1538471 SGTC_3186 9110464 49.47 µM 0.816716797664837 0.22954638565176 no 771 0.207045144805818 219 17018021 SGTC_2040 5100729 123 µM 0.816628592633919 0.229571569030951 no 772 0.207070354996943 232 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_365 0121-0052 13.6 µM 0.815987757053142 0.229754580181196 no 773 0.207253568995873 203 3101739 SGTC_1961 st076550 68.7 µM 0.815971226522336 0.229759302085027 no 774 0.207258296319554 253 1579337 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.815033808813997 0.230027161958977 no 775 0.207526478962679 259 5282309 SGTC_2099 5377090 177.372 µM 0.814829727519784 0.230085499768442 no 776 0.207584891058484 230 2243829 SGTC_2701 st077767 14.721 µM 0.811237111181208 0.231113824291071 no 777 0.208614758746951 210 5721188 SGTC_3155 9099265 49.47 µM 0.811108044008072 0.231150815209568 no 778 0.208651813401847 225 25236499 SGTC_845 0330-0138 4.51 µM 0.809486419533871 0.231615857546183 no 779 0.209117705619558 243 9039800 SGTC_1221 2958-7315 257 µM 0.808570881222767 0.231878641730539 no 780 0.209381009811351 234 4562705 SGTC_2330 7979373 200 µM 0.80823509912495 0.231975061851399 no 781 0.209477627921479 219 1863007 SGTC_1175 0741-0056 27.6 µM 0.806771420244248 0.232395619164756 no 782 0.209899093877361 236 765927 SGTC_1671 st016596 74.5 µM 0.803827758964286 0.233242700967207 no 783 0.210748227909329 247 2829167 SGTC_2837 9008476 45.46 µM 0.802101649646061 0.233740210252787 no 784 0.211247080414041 227 2992805 SGTC_2233 sulbentine 40.3845 µM 0.798949001025731 0.23465040143158 no 785 0.212159992085179 242 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1802 st050112 57.9 µM 0.797771403424984 0.234990884015834 no 786 0.212501579510514 236 4662563 SGTC_1854 st056233 32.9 µM 0.797705021408355 0.235010085385865 no 787 0.212520844598108 250 5393174 SGTC_1399 3562-5772 25 µM 0.795786069675563 0.235565527473959 no 788 0.213078194939862 238 23847490 SGTC_578 3460-0051 92 µM 0.794043496080167 0.23607054357545 no 789 0.213585055046368 270 2876744 SGTC_2797 7859098 81.82 µM 0.790032729910313 0.237235168879429 no 790 0.214754327029682 242 972681 SGTC_1119 parthenolide 318.541 nM 0.789997645372482 0.237245370448983 no 791 0.214764571724411 264 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_93 0109-0045 59.227 µM 0.788879777686694 0.23757054017723 no 792 0.215091138029095 254 88733 SGTC_1049 3226-0134 66 µM 0.78832238879927 0.237732766975223 no 793 0.215254077502991 220 5702385 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.786867889918071 0.238156381686411 no 794 0.215679603094299 216 77254 SGTC_1942 st076330 65.2 µM 0.786758883233451 0.238188145929116 no 795 0.215711513527666 256 24208414 SGTC_455 paf C-16 10 µM 0.785444953124459 0.238571204041545 no 796 0.216096366485856 223 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1523 st012844 44.7 µM 0.783971754461776 0.239001095362266 no 797 0.216528342087339 212 4274103 SGTC_1036 k216-0215 33.5 µM 0.783943919974434 0.239009221765965 no 798 0.216536508602894 212 622330 SGTC_2822 7994718 71.43 µM 0.781998232702498 0.239577648095777 no 799 0.217107806108406 279 1018011 SGTC_2162 5663267 200 µM 0.781520594553348 0.239717301289347 no 800 0.217248184420637 243 6456493 SGTC_2946 9065502 71.43 µM 0.77997849770785 0.240168487011068 no 801 0.217701765871533 197 16489101 SGTC_1441 4106-0040 13 µM 0.779557721612428 0.240291677742632 no 802 0.217825624790032 228 2904180 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.779398778614839 0.240338220484346 no 803 0.21787242154805 231 6708739 YPR165W RHO1 SGTC_2759 disulfiram 3.38 µM 0.777512021920605 0.240891088081482 no 804 0.218428372237586 242 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2976 9009005 19.48 µM 0.776905020698426 0.241069101825443 no 805 0.218607404445556 227 2993148 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.776035472387068 0.241324236677566 no 806 0.218864020836328 265 688801 SGTC_1669 st015249 58.4 µM 0.77327886905289 0.242134022747222 no 807 0.219678679329701 258 722793 SGTC_409 arachidonic acid 100 µM 0.771770888250998 0.242577633254288 no 808 0.220125068389063 246 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1090 efavirenz 20.7 µM 0.771383431529722 0.242691684428781 no 809 0.220239846404566 242 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2177 5811945 192 µM 0.770088773466919 0.243072988487361 no 810 0.220623617497885 242 5343475 SGTC_1864 st057645 30.4 µM 0.768295443223808 0.243601696768978 no 811 0.221155840619857 257 688666 SGTC_2289 7946404 165.07 µM 0.767379655819054 0.243871927883972 no 812 0.221427910364644 238 1246120 YPR165W RHO1 SGTC_2540 epiandrosterone 100 µM 0.767040393997005 0.24397207852238 no 813 0.221528749648385 268 441302 A steroid. SGTC_861 0443-0273 110 µM 0.766287564701659 0.244194394173073 no 814 0.221752607919 247 6149169 SGTC_563 tetrahydrosecaminediol 614 µM 0.764459278598485 0.244734754015472 no 815 0.222296797359894 241 334274 A psychoactive constituent of the cannabis plant. SGTC_969 1313-0238 134 µM 0.761732796811668 0.245541774805384 no 816 0.223109748403141 263 5212874 SGTC_1697 st025554 27.742 µM 0.761110369575399 0.245726209426112 no 817 0.223295573664728 244 1269519 SGTC_3094 9117742 49.47 µM 0.760270649607971 0.245975148995615 no 818 0.223546411057811 274 17149698 SGTC_2046 4110841 106 µM 0.759027302311713 0.246343994465357 no 819 0.223918112371049 246 44119630 YMR134W ERG29 SGTC_1117 retinoic acid 1.10837 µM 0.759019086047873 0.246346432848583 no 820 0.223920569808074 251 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1678 st019265 80.2 µM 0.756521811636597 0.247088161104974 no 821 0.224668200037616 246 5367020 SGTC_2995 9067767 71.4286 µM 0.756020622978085 0.247237165520973 no 822 0.224818415545068 227 11673567 SGTC_2155 5570423 76 µM 0.753171174540443 0.248085224703858 no 823 0.225673529345324 254 797402 SGTC_1786 berberine 21.6 µM 0.752616960350372 0.248250351243826 no 824 0.225840061424662 259 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2640 pentamidine 10.38 µM 0.751815702258638 0.248489187385271 no 825 0.226080948885684 252 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2305 7443522 69.23 µM 0.751506658339715 0.248581338798742 no 826 0.226173897573717 250 5415886 SGTC_1728 st035614 33.7865 µM 0.75106632360463 0.248712670247359 no 827 0.226306370853988 243 15945546 SGTC_2914 7968218 45.32 µM 0.750881698790942 0.248767746266871 no 828 0.226361927670339 217 2977111 SGTC_431 k089-0097 107 µM 0.750549557220933 0.248866844830073 no 829 0.226461894235475 251 5499420 SGTC_143 4032-1194 15.74 µM 0.749253056960464 0.249253872807263 no 830 0.226852347881017 257 1806963 SGTC_2925 9010536 32.5 µM 0.749082692391722 0.249304753387359 no 831 0.226903683039958 233 2994177 SGTC_1832 st054113 55 µM 0.748470521805012 0.249487628012024 no 832 0.227088199603804 244 1251267 SGTC_1634 st006576 41 µM 0.746705203865932 0.250015382965517 no 833 0.227620763930603 246 3915356 SGTC_3259 9138485 49.47 µM 0.746454640956207 0.250090338591539 no 834 0.22769641115133 229 17646153 SGTC_2445 5742597 35.57 µM 0.746263116072899 0.250147641093081 no 835 0.227754243796841 271 1774255 SGTC_2238 6671620 73.2395 µM 0.744766267277343 0.250595724421156 no 836 0.228206515323388 244 729941 SGTC_1646 st011709 75.6 µM 0.743730804889549 0.25090593984643 no 837 0.228519674578232 253 5757843 SGTC_1025 k007-0731 70 µM 0.743714073929866 0.250910953962927 no 838 0.228524736573917 265 6256118 SGTC_2991 9074669 71.4286 µM 0.743497906489674 0.250975742148315 no 839 0.228590144263224 265 17333109 SGTC_2749 bexarotene 57.39 µM 0.743466769431838 0.250985075057747 no 840 0.228599566543751 262 82146 An retinoic acid receptor inhibitor. SGTC_1098 clofazimine 15.1 µM 0.743103724854103 0.251093906283037 no 841 0.228709442341383 257 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2659 sanguinarine 24.21 µM 0.742679965104123 0.251220969891004 no 842 0.228837731142871 258 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3255 9139072 49.47 µM 0.741782381714075 0.251490220924128 no 843 0.229109598400589 260 17646060 SGTC_1796 st049173 110.4 µM 0.741372073476831 0.251613353198365 no 844 0.229233936162234 277 94134 SGTC_1363 1636-0063 10.4 µM 0.740907232926492 0.251752888923207 no 845 0.229374844827194 259 6072185 SGTC_62 0180-0423 3.232 µM 0.740818738841385 0.251779457685487 no 846 0.22940167583428 266 30102 YGL099W LSG1 SGTC_1899 st063254 59.6 µM 0.740056729482985 0.25200829857793 no 847 0.229632786408844 242 3093813 SGTC_328 k915-0120 63.5 µM 0.738416680361541 0.252501197786941 no 848 0.230130640694679 233 6624543 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.73707433958471 0.252905001654028 no 849 0.230538571445328 252 15053 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.736330809091908 0.253128817187154 no 850 0.230764700503992 251 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3219 9131112 49.47 µM 0.734421433209133 0.253704049284733 no 851 0.231345963945584 252 17612988 YMR079W SEC14 SGTC_2406 ethylparaben 405.7 µM 0.73309107024073 0.254105249247004 no 852 0.231751443076368 249 8434 A possible steroid mimic. SGTC_2477 5967686 25.23 µM 0.731946193279165 0.254450778096115 no 853 0.232100704994196 244 776118 SGTC_2398 5228213 48.84 µM 0.731863620469869 0.254475708444891 no 854 0.232125906393259 263 80771 YMR134W ERG29 SGTC_2043 5101342 149 µM 0.727668960157083 0.255743840557617 no 855 0.233408127824929 274 678451 SGTC_641 4092-0595 30 µM 0.727121465260493 0.255909602611273 no 856 0.233575775181212 253 786260 SGTC_3119 9125183 49.47 µM 0.726615389607639 0.256062874234858 no 857 0.233730799000206 230 22695334 SGTC_115 0527-0192 112.043 µM 0.726402033244664 0.256127506342776 no 858 0.233796172556934 287 4233931 SGTC_2592 piperlongumine 83.33 µM 0.72419371554421 0.256796972106976 no 859 0.234473408110904 264 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_825 1988-2224 89.6 µM 0.723241246366932 0.257086000168649 no 860 0.234765841145625 258 1180859 SGTC_2963 9082507 9 µM 0.723194812100996 0.257100095033252 no 861 0.234780102836527 264 16459611 SGTC_140 0062-0056 502.533 µM 0.722453340488484 0.257325219072441 no 862 0.235007901232635 249 3758964 SGTC_77 0828-0286 12.516 µM 0.721556206618566 0.257597741860213 no 863 0.23528368610035 254 745345 SGTC_197 4544-0043 41.561 µM 0.721351604104554 0.257659915046641 no 864 0.23534660727444 262 896523 SGTC_1057 3448-5381 134 µM 0.720389875940632 0.257952262649161 no 865 0.235642490826946 249 5497911 SGTC_3300 9124615 50.48 µM 0.719519195668207 0.258217081710282 no 866 0.235910539616147 240 24824903 SGTC_2442 5158906 48.48 µM 0.719263860271333 0.258294769172786 no 867 0.235989179369783 250 1893835 SGTC_3310 9130229 44.1445 µM 0.718878639437526 0.258411998047008 no 868 0.236107849365641 253 7761258 SGTC_258 haloperidol 50.781 µM 0.718507396401397 0.258524999330059 no 869 0.236222244502613 279 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1459 k035-0031 35.7 µM 0.713642882385146 0.260008051830894 no 870 0.237724016887531 256 3877128 YMR208W ERG12 SGTC_1317 1273-0028 910 nM 0.709749221007709 0.261198272152444 no 871 0.238929831617764 268 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1204 4049-0315 18.3 µM 0.709059181529146 0.261409496146376 no 872 0.239143875940211 265 588402 SGTC_1076 itraconazole 331 nM 0.70880458469698 0.261487451457663 no 873 0.239222876149497 258 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_965 1291-5240 308 µM 0.707488596242331 0.261890585761143 no 874 0.239631448484302 286 2834598 SGTC_3082 9117008 49.47 µM 0.707396875335078 0.261918695030173 no 875 0.239659939084176 267 41448529 SGTC_2600 tangeritin 87.95 µM 0.706986928793329 0.26204434829881 no 876 0.239787300397678 271 68077 A bioactive flavone. SGTC_871 0574-0004 149 µM 0.706631696400514 0.262153256042816 no 877 0.239897693092871 277 9551173 SGTC_2185 6113692 200 µM 0.704562574496893 0.26278807158596 no 878 0.240541247977087 282 874150 SGTC_2322 7413319 38.22 µM 0.7040766218246 0.262937277895633 no 879 0.240692529070294 263 1840400 SGTC_3007 9078383 71.4286 µM 0.703903263562633 0.262990516081857 no 880 0.240746509462756 257 6496995 SGTC_1917 st066507 28.5 µM 0.703576512563975 0.263090876034825 no 881 0.24084827128008 262 3156428 SGTC_2953 9074162 66.49 µM 0.702354532474928 0.263466374547453 no 882 0.241229046420492 250 16451992 SGTC_654 1124-0271 80.9 µM 0.700995551261681 0.263884292756356 no 883 0.241652895770556 264 5403748 SGTC_2526 patulin 37.61 µM 0.700658713750332 0.263987930333373 no 884 0.24175801369201 271 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_277 nystatin 15.5 µM 0.699711789679311 0.264279389359485 no 885 0.242053656106811 287 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_937 3122-0005 46.7 µM 0.699517958582594 0.264339069906893 no 886 0.242114196943522 267 759535 SGTC_2020 4017018 200 µM 0.697868789298868 0.26484712611002 no 887 0.24262962728647 278 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2969 9091408 28.7 µM 0.696995729472996 0.265116288661459 no 888 0.242902733192688 258 4286311 SGTC_1484 3473-2379 286 µM 0.694690202181102 0.265827745263649 no 889 0.243624734771291 270 671917 SGTC_1130 3454-2858 15.9 µM 0.694341694927901 0.265935374330282 no 890 0.243733974444531 289 715628 YIL048W NEO1 SGTC_1529 apigenin 74 µM 0.693851498473539 0.266086798457751 no 891 0.243887671371532 282 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3304 9125678 46.087 µM 0.693753756895529 0.266116996538649 no 892 0.24391832366417 269 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_632 0781-2353 4.65 µM 0.693158368298537 0.26630098431867 no 893 0.244105085668154 283 6811515 YHR007C ERG11 SGTC_1718 roemerine 11.9335 µM 0.691807231667538 0.266718753049248 no 894 0.244529197289785 256 235224 An aporphine alkaloid with mutagenic activity. SGTC_347 4534-1311 26.2 µM 0.690628986006231 0.267083334445323 no 895 0.244899363485751 274 2862016 SGTC_3010 9080089 71.4286 µM 0.690029286093591 0.267268994559237 no 896 0.245087885292414 255 17027233 SGTC_92 0063-0024 660.874 µM 0.687727707282237 0.267982140648693 no 897 0.245812134226837 280 3594437 SGTC_713 1488-1073 324 µM 0.685875784048183 0.26855665540157 no 898 0.246395720932451 287 3312542 SGTC_35 0133-0054 64.071 µM 0.685871318215555 0.26855804156689 no 899 0.246397129123418 269 99677 SGTC_628 1636-0253 16 µM 0.684199149825797 0.269077324368362 no 900 0.246924709522569 277 4456143 SGTC_59 0330-0160 1.33 µM 0.684178621784056 0.269083702369627 no 901 0.246931190012359 291 4293482 SGTC_2775 cyproheptadine 69.59 µM 0.683636403251403 0.269252195510409 no 902 0.247102395725515 276 2913 A selective serotonin reuptake inhibitor. SGTC_786 4544-0069 423 µM 0.680646730951186 0.270182178444194 no 903 0.248047525051167 275 748821 YLR208W SEC13 SGTC_1324 1418-0026 34.4 µM 0.678715153316788 0.270783878046464 no 904 0.248659181438813 276 1372513 SGTC_1318 1280-3875 124 µM 0.678390281162892 0.270885143612958 no 905 0.248762134822652 293 373245 SGTC_1041 0206-0046 107 µM 0.678160321859845 0.270956835413571 no 906 0.248835023632214 285 50494 SGTC_2795 7780010 54.55 µM 0.677188080993125 0.271260044489753 no 907 0.249143314546128 277 953673 SGTC_864 0469-0573 172 µM 0.674354595935619 0.272144676335161 no 908 0.250042950815215 286 689425 SGTC_149 3970-0822 46.1 µM 0.672719768368154 0.272655731378069 no 909 0.250562794340058 282 3114250 YBL034C STU1 SGTC_1360 1598-0022 39.8 µM 0.672485145824532 0.272729114589823 no 910 0.250637446723997 287 761525 SGTC_3134 9127454 49.47 µM 0.672188218083449 0.272821999129813 no 911 0.250731940311116 289 24262820 SGTC_1839 st053978 48 µM 0.671244427522963 0.273117338600133 no 912 0.251032415238721 285 3788398 SGTC_866 0495-0101 262 µM 0.668541289890499 0.273964104654405 no 913 0.251894067294238 265 635694 SGTC_177 1327-0068 8.361 µM 0.668402493272811 0.274007618114584 no 914 0.251938352196444 280 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2329 6138490 200 µM 0.667088734080352 0.274419657528845 no 915 0.252357727924567 290 720019 SGTC_1867 st057372 64 µM 0.665292861517661 0.274983398319386 no 916 0.252931597754038 259 688837 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.664833020838375 0.275127838204217 no 917 0.253078649889092 285 688788 SGTC_1974 st069448 26.9 µM 0.664653387557487 0.275184272698615 no 918 0.253136106906595 267 6323587 YNR016C ACC1 SGTC_841 0251-0215 91.2 µM 0.663993405119114 0.275391665024087 no 919 0.253347266010303 285 3888614 SGTC_630 4356-0227 183 µM 0.663770055293029 0.275461867698352 no 920 0.253418746980195 301 779312 SGTC_1573 oleylamine 1.06 µM 0.663341890107657 0.275596471956452 no 921 0.253555806771886 290 5356789 An amine of the fatty acid oleic acid. SGTC_2752 diclazuril 33.15 µM 0.66332106130263 0.275603020828519 no 922 0.253562475265765 274 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1747 st037496 66.6 µM 0.66321751403138 0.275635578696669 no 923 0.253595628047546 293 723305 SGTC_532 1548-0774 215 µM 0.662784422873693 0.275771773948011 no 924 0.253734315734957 309 5932993 SGTC_476 mead acid 10 µM 0.662628024867568 0.275820964943901 no 925 0.253784408459363 299 5312531 An omega 9 fatty acid. SGTC_1829 berberine 14.4 µM 0.662022551370732 0.276011441803798 no 926 0.253978384540026 282 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1359 1582-0056 520 nM 0.66172242938324 0.276105881590984 no 927 0.2540745637176 297 3661189 SGTC_2790 5423970 71.43 µM 0.661090565535109 0.27630476287478 no 928 0.254277117637206 291 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1844 rapamycin 4 nM 0.661041520940645 0.276320202765675 no 929 0.254292843195181 279 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2351 9026858 72.31 µM 0.661016829820287 0.276327976019071 no 930 0.254300760298218 299 1409300 SGTC_919 tnp00227 403.569 nM 0.659013313524976 0.276959079870288 no 931 0.254943609702244 306 1269246 A methoxyflavone. YNL221C POP1 SGTC_202 3594-0513 34.79 µM 0.658614554428934 0.277084772383633 no 932 0.255071657168906 283 708429 SGTC_171 k064-0041 9.68 µM 0.658336021856336 0.277172584954209 no 933 0.255161118065676 280 53325 SGTC_2497 7-hydroxyflavone 100 µM 0.658106166336433 0.277245061431871 no 934 0.255234956907002 308 5281894 SGTC_3044 9093193 49.47 µM 0.654634132205113 0.27834096574916 no 935 0.256351671440058 291 25236277 SGTC_620 0109-0052 432 µM 0.65435003860061 0.278430729722382 no 936 0.256443157379862 292 493037 SGTC_1801 st050089 28.441 µM 0.652860375774269 0.278901643574717 no 937 0.25692314802417 274 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_850 0388-0143 75.9 µM 0.651607245144073 0.279298084470963 no 938 0.257327286330128 288 67273 SGTC_1685 st024049 53.0905 µM 0.651428556758378 0.279354636696765 no 939 0.257384940761187 291 1941139 SGTC_3062 9077494 49.47 µM 0.651178073417601 0.279433920325299 no 940 0.257465771382921 242 16459633 SGTC_650 1328-0195 38 µM 0.650560818908554 0.279629341939244 no 941 0.257665014818789 298 2780821 SGTC_1439 4092-1168 46 µM 0.650318944738325 0.27970593693166 no 942 0.257743111149879 306 2886240 SGTC_1173 0443-0020 122 µM 0.650078392240407 0.279782123482744 no 943 0.257820792924068 288 5331295 SGTC_198 3454-2873 16.191 µM 0.649493413768569 0.279967436857276 no 944 0.25800975108975 285 710957 SGTC_3253 9135987 49.47 µM 0.648833649996746 0.280176512601224 no 945 0.258222952362114 281 4182430 SGTC_1559 coumarin 343 70.1 µM 0.647725874100022 0.280527731137943 no 946 0.258581133095112 295 108770 A hepatotoxic, DNA x-linker. SGTC_1297 1068-0111 14.1 µM 0.647008316566577 0.280755345234645 no 947 0.258813280493239 289 767057 SGTC_976 1348-1067 47.6 µM 0.646292940203184 0.280982356318792 no 948 0.259044829541671 292 5310671 YGL099W LSG1 SGTC_2455 5377712 9.75 µM 0.645437914798408 0.281253798682419 no 949 0.259321719885043 263 2243908 SGTC_1401 3807-4679 7.6 µM 0.645179795595985 0.281335767887912 no 950 0.259405338922002 302 3291456 SGTC_2584 androsterone 48.74 µM 0.64392142585087 0.28173554508706 no 951 0.259813193625641 263 2754130 A steroid. SGTC_2733 amorolfine 100 µM 0.643270305398019 0.281942509953335 no 952 0.260024360414519 318 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3288 9119690 36.221 µM 0.641985925550091 0.28235097697411 no 953 0.260441160731632 307 17595618 YKL019W RAM2 SGTC_1806 st050005 60.3 µM 0.640944934658441 0.282682248559991 no 954 0.260779229999895 271 5194765 SGTC_1504 k297-0033 30 µM 0.640064926607543 0.28296243663548 no 955 0.261065194941315 249 4388117 SGTC_399 oxolinic acid 75 µM 0.639579263876656 0.283117125144812 no 956 0.261223083540806 288 4628 A DNA gyrase inhibitor. SGTC_2114 5491910 81.25 µM 0.63907854289198 0.283276652334535 no 957 0.26138591892318 292 2849228 SGTC_1665 st014639 11.4 µM 0.638560331039169 0.283441797409778 no 958 0.261554497245815 292 981133 YIL048W NEO1 SGTC_210 3551-0445 56.827 µM 0.638091041955233 0.283591391460998 no 959 0.261707208755298 295 2865180 YOR207C RET1 SGTC_1404 3909-7820 48.3 µM 0.637166393910563 0.283886249735117 no 960 0.262008232584244 282 23741373 SGTC_833 3852-0053 558 µM 0.636787946036037 0.284006974161136 no 961 0.262131489368144 304 3123681 SGTC_95 0471-0001 561.058 µM 0.636167971971957 0.284204798219664 no 962 0.26233347306917 274 4015405 SGTC_1019 4262-0212 3.4 µM 0.636153026501998 0.284209567899272 no 963 0.262338343194235 293 4677213 SGTC_2183 6420625 130.508 µM 0.634990739830274 0.284580615865129 no 964 0.262717227249819 296 2897619 SGTC_2176 5809774 33.9695 µM 0.634849023064295 0.284625873290331 no 965 0.262763443445768 275 2870539 SGTC_3267 9137951 49.47 µM 0.634181143265532 0.284839207780435 no 966 0.262981306130044 309 16643986 SGTC_569 4130-2812 160 µM 0.634175040383948 0.284841157517535 no 967 0.262983297318334 309 743552 SGTC_2794 7785382 27.27 µM 0.633184769076162 0.285157611839802 no 968 0.263306495365798 292 2205081 SGTC_269 exalamide 29 µM 0.631546420434618 0.285681535501709 no 969 0.26384165354465 285 3316 A derivative of salicylamide. SGTC_3121 9125696 49.47 µM 0.627098425262313 0.287106254308232 no 970 0.265297359658553 321 1235365 SGTC_2433 5607874 27.82 µM 0.624807747938802 0.287841281663082 no 971 0.266048622461419 301 2252428 SGTC_2151 5563267 85.4165 µM 0.624723004577856 0.287868490960569 no 972 0.266076436002329 313 5310824 SGTC_1800 st050079 29.0735 µM 0.623269160267434 0.288335478628043 no 973 0.266553830139557 297 3645560 SGTC_1006 4099-6547 255 µM 0.620632385576363 0.289183344205805 no 974 0.267420763098541 309 3146833 SGTC_2684 capsaicin 100 µM 0.618946170476322 0.289726167253723 no 975 0.267975910535017 314 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2730 imipramine 71.33 µM 0.615998913358991 0.290676089001661 no 976 0.268947618487517 286 3696 A tricyclic antidepressant. SGTC_541 4513-1321 94 µM 0.615948375284563 0.290692390475808 no 977 0.268964296257648 296 747515 SGTC_1879 gemcitabine 100 µM 0.615466162195499 0.290847953797823 no 978 0.269123454644519 323 60750 A nucleoside analog which inhibits DNA replication. SGTC_181 1447-1644 8.07 µM 0.615451216349489 0.290852775992209 no 979 0.269128388398574 315 534600 SGTC_2869 9037858 32.47 µM 0.615365164589777 0.290880540842594 no 980 0.269156795717439 291 27187042 SGTC_700 3453-2283 142 µM 0.612883591868482 0.291681759948075 no 981 0.269976656649629 294 565664 SGTC_1574 spiramycin 23.7 µM 0.612728549191643 0.291731852308117 no 982 0.270027921033503 308 6419898 An antibiotic and protein synthesis inhibitor. SGTC_817 1391-0715 46 µM 0.612384729723895 0.291842950401126 no 983 0.270141621256497 323 1353946 SGTC_1877 wortmannin 25 µM 0.611069670871799 0.29226806600483 no 984 0.27057672871689 311 312145 A covalent inhibitor of PI 3-kinase. SGTC_12 0849-0099 9.267 µM 0.60994830452157 0.292630794515977 no 985 0.270948026354326 303 6071388 SGTC_3332 9141069 11.198 µM 0.609741313797738 0.292697772688863 no 986 0.271016591210302 299 17332883 SGTC_383 2324-0395 7.37 µM 0.608303754501821 0.293163135238865 no 987 0.271493015684908 288 3146421 SGTC_3129 9127257 49.47 µM 0.607263661333557 0.293500044960716 no 988 0.271837975003708 315 837894 SGTC_2315 7733312 200 µM 0.607041867618175 0.293571912156297 no 989 0.271911563739351 292 726316 SGTC_2860 9025725 38.96 µM 0.606843456426419 0.293636209682437 no 990 0.271977402805432 301 40546248 SGTC_503 tyrphostin 8 294 µM 0.606118694537955 0.293871132844551 no 991 0.272217968924881 325 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1209 2323-2347 50.3 µM 0.605925987468011 0.293933611234188 no 992 0.272281950886282 290 5412760 SGTC_2049 5262831 67.185 µM 0.605897984802425 0.29394269061021 no 993 0.272291248860073 309 763417 SGTC_3009 9080819 71.4286 µM 0.603270186739623 0.294795284801643 no 994 0.273164481376198 297 17027216 SGTC_3270 9137563 49.47 µM 0.602058795642423 0.29518870656387 no 995 0.27356750042516 291 17015724 SGTC_2197 6588183 93.1375 µM 0.598598639518864 0.296313785652905 no 996 0.274720281759068 301 884136 SGTC_801 0866-0028 10.1 µM 0.598128745611688 0.296466724444458 no 997 0.274877015562441 294 6849771 SGTC_1189 1431-2119 7.28 µM 0.597995163764671 0.296510208619678 no 998 0.274921580027404 317 3107275 SGTC_2213 7173844 200 µM 0.597161127060758 0.296781774135114 no 999 0.275199904900346 301 892728 SGTC_2250 alverine citrate 130 µM 0.596529461183762 0.296987522680117 no 1000 0.275410789251041 291 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1353 1498-1206 8.11 µM 0.596380423760683 0.297036077212596 no 1001 0.275460557621605 285 6756808 SGTC_173 1273-0061 2.693 µM 0.596060368821695 0.297140359385412 no 1002 0.275567449169456 298 2847414 YPL266W DIM1 SGTC_2666 tannic acid 100 µM 0.594984198451339 0.297491126211093 no 1003 0.275927016736024 300 16134267 A thiamine antagonist. SGTC_558 k064-0027 21.3 µM 0.594433160141793 0.297670804723326 no 1004 0.276111217557968 304 5088526 SGTC_2118 5526350 200 µM 0.594411085197145 0.297678003790176 no 1005 0.276118598017292 313 743594 SGTC_2395 5646831 180.19 µM 0.592542074963951 0.298287812097127 no 1006 0.276743827296766 326 6808628 SGTC_875 0709-0210 25.7 µM 0.592069553820825 0.29844207320103 no 1007 0.276902006860202 308 6251364 SGTC_2512 diallyl trisulfide 49.23 µM 0.591948938256916 0.298481455645767 no 1008 0.276942390805914 328 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2304 7443016 91.4 µM 0.591016017172839 0.298786145534935 no 1009 0.277254844505472 310 939854 SGTC_2282 7944268 200 µM 0.590540401596211 0.298941534875134 no 1010 0.277414203889753 304 2970414 SGTC_3097 9117246 49.47 µM 0.586496778309143 0.300264115293944 no 1011 0.278770862943646 289 16423892 SGTC_1405 3909-7894 12 µM 0.585712215850538 0.300521034530123 no 1012 0.279034461781541 306 7104060 SGTC_3354 9151612 71.43 µM 0.585686085493059 0.300529593098659 no 1013 0.279043243195866 299 27261949 SGTC_3158 9100007 49.47 µM 0.583972145950951 0.30109120599576 no 1014 0.279619526083509 305 19297233 SGTC_2401 5128683 200 µM 0.582898068113737 0.301443393937827 no 1015 0.279980960613836 320 708373 SGTC_2786 7743617 45.45 µM 0.582210481084971 0.301668949621099 no 1016 0.280212457198693 298 583674 SGTC_136 0097-0015 404.482 µM 0.581877759488716 0.301778122678727 no 1017 0.280324511084378 303 4861337 SGTC_2091 4-phenylthiadiazole 200 µM 0.581088733832316 0.302037089807124 no 1018 0.280590325639509 306 270010 SGTC_594 1487-1584 10.8 µM 0.580824996513996 0.302123673621942 no 1019 0.280679203193687 324 5013332 SGTC_1362 1611-0397 101 µM 0.580786208743996 0.302136408418034 no 1020 0.280692275538079 301 27816 SGTC_138 0850-0259 40.9225 µM 0.580143147888859 0.302347573187127 no 1021 0.280909044305236 307 6813004 SGTC_3012 9080433 71.4286 µM 0.580141642142278 0.302348067713547 no 1022 0.280909551970849 329 17688859 SGTC_2318 6029776 164 µM 0.578144937374627 0.303004156558982 no 1023 0.281583135065712 333 818325 SGTC_1953 st076800 12.1 µM 0.5781013731729 0.303018478236464 no 1024 0.281597840013586 309 297591 SGTC_1013 4112-3890 241 µM 0.577538723858127 0.303203475714601 no 1025 0.281787793645746 305 705171 SGTC_1813 st051246 8.6015 µM 0.576943068142339 0.303399380616082 no 1026 0.281988957701516 299 5291959 SGTC_2239 6685329 187.64 µM 0.575491376413653 0.303877063466821 no 1027 0.282479510604935 280 805680 SGTC_221 trifluoperazine 10.304 µM 0.574962879488895 0.304051049973418 no 1028 0.282658201116031 317 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_315 k915-0449 187 µM 0.574121572651135 0.304328108210733 no 1029 0.282942768052768 319 20970215 YNL149C PGA2 SGTC_726 3448-4391 34.2 µM 0.573731206102962 0.304456701459725 no 1030 0.283074853874659 321 1356692 SGTC_1329 1447-1697 50.6 µM 0.57340088076703 0.304565535017921 no 1031 0.283186647047823 307 2840515 SGTC_425 3825-7017 13.1 µM 0.571543017838782 0.305177974385781 no 1032 0.283815804436943 322 3397440 SGTC_1169 aniline yellow 25.8 µM 0.571541388047263 0.305178511881937 no 1033 0.283816356652573 318 6051 A DNA damaging agent. SGTC_973 1325-0077 65.9 µM 0.571327086753684 0.305249190913239 no 1034 0.283888971968331 320 2835149 SGTC_271 rotenone 740 µM 0.570510775212539 0.305518486349776 no 1035 0.284165657973511 336 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1991 st073000 8.92 µM 0.570420220081151 0.305548366338856 no 1036 0.284196359269748 337 4301969 YIL048W NEO1 SGTC_1707 st032323 6.317 µM 0.569970978164857 0.305696619421915 no 1037 0.284348691137639 294 3132057 YMR211W DML1 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.569088377408239 0.305987976810382 no 1038 0.284648082724629 324 2346 DNA damaging agent; causes G2/M arrest. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.567846995548501 0.30639798006589 no 1039 0.285069432837112 307 165521 SGTC_114 0364-0001 490.298 µM 0.567727825901247 0.306437352149042 no 1040 0.285109897063292 306 4003655 SGTC_997 3996-0078 137 µM 0.567718423470808 0.306440458683438 no 1041 0.285113089788684 313 735687 SGTC_2735 sertaconazole 140 nM 0.565857943784608 0.307055428980238 no 1042 0.28574517649332 340 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_527 4476-4215 268 µM 0.56568056874449 0.307114087613439 no 1043 0.28580547337578 300 4418754 SGTC_2249 haloperidol 116.36 µM 0.56497204917711 0.307348447091644 no 1044 0.286046387902953 315 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1478 0453-0656 35.7 µM 0.564890519960742 0.307375419843591 no 1045 0.286074116083034 328 5258496 SGTC_2263 7948595 193.29 µM 0.563506776267474 0.307833370058553 no 1046 0.286544923571666 334 2971371 SGTC_1258 0671-0043 57.1 µM 0.563409571858123 0.307865551141009 no 1047 0.286578010390604 338 4298767 SGTC_2211 7117706 200 µM 0.559168136261379 0.309271182931548 no 1048 0.288023488532101 314 822771 SGTC_2413 inermin 26.06 µM 0.556929716027596 0.310014134604336 no 1049 0.288787725313402 353 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_293 4049-0273 38.5 µM 0.555252413987873 0.310571355217492 no 1050 0.289361011246164 310 1380311 SGTC_702 1488-0190 94 µM 0.554062813895627 0.310966818878601 no 1051 0.289767929113251 298 949357 SGTC_1115 galangin 695.678 nM 0.553154763302663 0.31126883289374 no 1052 0.29007871996817 335 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1880 MG-132 525 µM 0.552753587127268 0.311402302983462 no 1053 0.290216076912847 317 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_290 2043-6722 48.1 µM 0.551428314114092 0.311843393428922 no 1054 0.290670047755122 318 773758 YLR208W SEC13 SGTC_1623 st003709 20.3 µM 0.549900685827889 0.312352168765105 no 1055 0.291193746903553 305 16192618 SGTC_1485 3909-9022 254 µM 0.549721793357205 0.312411772186871 no 1056 0.291255103345519 324 714516 SGTC_1785 bathophenanthroline 24 µM 0.549222834661131 0.312578041257024 no 1057 0.291426267808575 307 72812 An iron chelator. SGTC_2923 7992654 58.14 µM 0.548480469771104 0.312825491699309 no 1058 0.291681017961018 296 2985126 SGTC_167 3672-0051 66.205 µM 0.546935165160814 0.313340854320997 no 1059 0.292211637783249 328 3237971 SGTC_507 nimesulide 162 µM 0.546712127310992 0.313415268095367 no 1060 0.2922882606001 326 4495 A COX2 inhibitor. SGTC_2309 7664088 163.95 µM 0.546471730472812 0.313495481983568 no 1061 0.292370857417291 330 704922 SGTC_1721 st082152 9.2685 µM 0.546198435360208 0.313586683845737 no 1062 0.292464770778039 329 5296051 SGTC_1367 1812-0510 76.9 µM 0.545695345524558 0.313754600761969 no 1063 0.292637685962259 303 1142582 YDR527W RBA50 SGTC_2783 7738165 71.43 µM 0.54525249703784 0.313902442783888 no 1064 0.292789935102075 322 17201110 SGTC_298 1391-0729 10 µM 0.543461790296745 0.314500562817145 no 1065 0.293405946010085 328 3237558 SGTC_323 4013-0906 34.3 µM 0.542903614642771 0.314687100637402 no 1066 0.293598083544069 297 2910086 SGTC_1437 4092-1038 11.6 µM 0.541976585911471 0.314997010697184 no 1067 0.293917317861091 331 3977136 SGTC_1322 1348-1070 12 µM 0.541645827867266 0.315107616213468 no 1068 0.294031257508034 316 6758089 SGTC_3313 9133968 57.047 µM 0.541042634809973 0.315309366700801 no 1069 0.294239098219178 310 1494643 SGTC_1935 st074532 41.6 µM 0.540171620096278 0.315600792917307 no 1070 0.294539341259441 332 2829742 SGTC_531 3788-1495 174 µM 0.538305128117171 0.316225674444752 no 1071 0.295183205793312 329 2896655 SGTC_562 3772-2733 112 µM 0.538113030386761 0.316290016546697 no 1072 0.295249508532692 326 2876874 YIL048W NEO1 SGTC_2831 7999036 19.48 µM 0.537538956569876 0.316482332629099 no 1073 0.295447691572335 344 2988270 SGTC_2840 9008771 71.43 µM 0.536246563763231 0.31691546884927 no 1074 0.295894078071743 288 2992978 SGTC_396 dithiazanine 1.25 µM 0.534791663785857 0.317403368561961 no 1075 0.296396964057762 305 10578 An antihelmenthic. SGTC_1920 st075728 45.7 µM 0.533683201734391 0.317775303661917 no 1076 0.296780366579261 356 3400306 SGTC_1489 4065-0444 182 µM 0.532282396514362 0.318245595143763 no 1077 0.297265211255082 335 2877968 SGTC_1272 0839-0021 27 µM 0.531495432067346 0.318509930887147 no 1078 0.297537752950141 348 5027250 SGTC_506 n9-isopropylolomoucine 153 µM 0.530205253721338 0.318943492478034 no 1079 0.297984814425635 334 6610355 SGTC_2857 9024691 58.44 µM 0.529920412296132 0.319039246233319 no 1080 0.298083556464706 348 16478292 SGTC_1179 1021-1431 9.29 µM 0.528392595679738 0.319553050889491 no 1081 0.298613437776251 357 2840958 SGTC_1699 st031318 29.054 µM 0.522959434058465 0.321383025224977 no 1082 0.300501241600364 339 5340658 SGTC_924 2046-0044 21.3 µM 0.522068711026206 0.321683450411612 no 1083 0.300811245381144 314 3623589 SGTC_3006 9075424 71.4286 µM 0.519254608494264 0.322633363223632 no 1084 0.301791601230837 322 7465181 SGTC_2591 skatole 100 µM 0.518842979609134 0.322772407674176 no 1085 0.301935121721274 358 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1067 clotrimazole 1.36 µM 0.518117115393345 0.323017658298991 no 1086 0.302188279680242 308 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_333 3486-0131 40.1 µM 0.517967455744738 0.323068233972695 no 1087 0.302240487968856 334 6744690 SGTC_2292 7671323 168.05 µM 0.514659566725808 0.324186928972292 no 1088 0.303395466249055 356 937504 SGTC_1104 tacrolimus 29.8 µM 0.514657724777148 0.324187552344518 no 1089 0.303396109930562 346 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2588 indole-3-carbinol 100 µM 0.514618297245168 0.324200895955346 no 1090 0.303409888296537 352 3712 Induces cell cycle arrest. SGTC_3297 9117502 71.43 µM 0.513674995446327 0.324520208495294 no 1091 0.303739618358334 300 7453720 SGTC_3053 9095903 49.47 µM 0.513464308675591 0.324591544695611 no 1092 0.303813285517866 376 17174018 SGTC_1778 st046819 58.9 µM 0.512717722145627 0.324844382395986 no 1093 0.304074395519078 347 671715 SGTC_1386 3228-0095 33.8 µM 0.512567182333007 0.324895373729565 no 1094 0.304127057191323 352 870181 SGTC_1841 st054148 70 µM 0.509947702469607 0.325783176963482 no 1095 0.305044050541986 350 675442 SGTC_282 k297-0036 65.7 µM 0.5098544784176 0.32581479103563 no 1096 0.305076707817442 334 5061378 SGTC_3126 9127922 49.47 µM 0.507145083636856 0.326734145408078 no 1097 0.306026511950071 377 45595682 SGTC_2748 diazoxide 86.69 µM 0.50678279799141 0.326857156447655 no 1098 0.306153613734871 317 3019 A potassium channel activatior. SGTC_316 k060-0003 58.6 µM 0.506109412741413 0.327085848728537 no 1099 0.306389921542929 342 6152314 SGTC_591 4299-0174 154 µM 0.505024108815831 0.327454571762742 no 1100 0.306770951461301 353 5509088 SGTC_2757 clomiphene 4.22 µM 0.504825730531701 0.327521987356649 no 1101 0.306840620959898 362 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2997 9067075 71.4286 µM 0.50420500211434 0.327732968013796 no 1102 0.307058662856928 363 27209819 SGTC_2167 5876490 200 µM 0.504195669729071 0.327736140437275 no 1103 0.307061941544184 350 686534 SGTC_3139 9095020 49.47 µM 0.50407685541165 0.327776530912124 no 1104 0.307103685167196 300 25236292 SGTC_2627 acetyl isogambogic acid 100 µM 0.50227175217804 0.328390416499297 no 1105 0.307738188308306 339 6857789 A caspase activator and apoptosis inducer. SGTC_2153 5569715 200 µM 0.501944244743251 0.328501846066575 no 1106 0.307853370597736 355 2054701 SGTC_2928 9011484 9.79 µM 0.501635218840932 0.328607001553295 no 1107 0.307962070413151 348 2994751 SGTC_575 k072-0246 11.9 µM 0.497122336893027 0.33014419014668 no 1108 0.309551391936372 341 6796779 SGTC_2210 7115885 190.385 µM 0.497018308458293 0.330179658517908 no 1109 0.309588070272565 355 2927039 SGTC_2984 9022109 38.96 µM 0.496941610029251 0.33020580973358 no 1110 0.309615113812381 348 6459207 SGTC_2372 9071633 200 µM 0.496212022519448 0.33045461248375 no 1111 0.309872414785734 324 21321366 SGTC_799 1310-0557 151 µM 0.495585734918453 0.330668247862927 no 1112 0.310093359674345 361 5354492 SGTC_2279 7948423 32.93 µM 0.495418890953127 0.330725169961588 no 1113 0.310152231299657 310 1247112 SGTC_2457 5731572 11.68 µM 0.494768689341729 0.330947036368169 no 1114 0.310381704215586 367 2865357 SGTC_2987 9018338 71.43 µM 0.494000569439484 0.331209216204617 no 1115 0.310652888664052 342 5055682 SGTC_1857 st056007 79.3 µM 0.493155234966745 0.331497847100842 no 1116 0.310951452643468 323 619834 SGTC_2534 helenine 20.12 µM 0.493041001143756 0.331536858763711 no 1117 0.31099180847936 349 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1773 st048542 73.5835 µM 0.491054297513512 0.332215624144679 no 1118 0.311694022320463 345 3237138 SGTC_98 0074-0023 107.663 µM 0.490891357512529 0.332271317727332 no 1119 0.311751645006685 342 3563821 SGTC_3042 9091578 49.47 µM 0.489905181326589 0.332608475943813 no 1120 0.312100498216299 329 25236497 SGTC_1001 4048-4355 44.4 µM 0.48921343210621 0.332845055030945 no 1121 0.312345300477096 367 21824233 SGTC_1925 st057770 10.1 µM 0.487328158296123 0.333490158689575 no 1122 0.313012898023118 323 5989122 SGTC_3122 9126309 49.47 µM 0.486334850631084 0.33383024737789 no 1123 0.313364886848314 369 17591206 SGTC_2617 dihydrotanshinone i 20.83 µM 0.485389847018927 0.334153924481854 no 1124 0.313699916512341 315 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1163 k060-0048 49.9 µM 0.484620581616645 0.334417499874189 no 1125 0.313972755669993 331 6809982 SGTC_2944 9067346 25.62 µM 0.484201839529614 0.33456100888369 no 1126 0.314121315762102 346 6473075 SGTC_1837 st055472 66.5 µM 0.483379251788918 0.334842992051288 no 1127 0.31441323872791 322 676091 SGTC_2713 st079149 53.4 µM 0.48248700161037 0.335148960825281 no 1128 0.314730015013614 337 3103253 SGTC_1960 st011366 51.8 µM 0.481338669007538 0.335542905918745 no 1129 0.315137909158867 336 3972846 SGTC_1464 k208-0027 110 µM 0.480389667897071 0.33586860519351 no 1130 0.315475169862463 370 X1464 SGTC_3234 9132280 49.47 µM 0.480185080175003 0.335938836315908 no 1131 0.315547897416793 335 17612295 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.479879142788751 0.336043869562676 no 1132 0.315656666432383 351 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1494 4358-1428 177 µM 0.477900166529458 0.336723593044418 no 1133 0.316360631432785 345 1564571 SGTC_750 4073-0104 132 µM 0.475671612883753 0.337489678364015 no 1134 0.317154173837988 330 22330957 SGTC_2717 st081029 62.2815 µM 0.47268623654681 0.338516984225816 no 1135 0.318218523713828 363 5292846 SGTC_974 1326-0144 138 µM 0.471795182883466 0.33882384053154 no 1136 0.31853649479884 363 5411856 SGTC_565 1418-0001 44.5 µM 0.471564358763047 0.338903347966759 no 1137 0.318618885831086 354 2862145 SGTC_2071 5230951 39.92 µM 0.471540174620752 0.338911678617019 no 1138 0.318627518708228 366 1799272 SGTC_3199 9111318 49.47 µM 0.469900295067671 0.339476747378872 no 1139 0.31921312674392 348 8548020 SGTC_2179 6298986 200 µM 0.467832337366324 0.340189837756488 no 1140 0.319952246750353 343 738374 SGTC_2144 5628481 200 µM 0.466920952685293 0.340504290740677 no 1141 0.320278216976417 331 2818399 SGTC_3230 9131665 49.47 µM 0.466324706804999 0.340710072129654 no 1142 0.320491548233541 357 15943720 SGTC_2441 5730946 39.09 µM 0.466304672166834 0.340716987476061 no 1143 0.320498717472135 330 1774275 SGTC_2227 7312221 64.1025 µM 0.465554331050514 0.340976020888047 no 1144 0.320767269380655 363 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1165 k072-0275 30.3 µM 0.464728171336098 0.34126131518983 no 1145 0.321063065776691 349 6153523 YGL055W OLE1 SGTC_1873 rapamycin 2 nM 0.463690774581838 0.34161968361832 no 1146 0.321434653863561 364 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3214 9129694 49.47 µM 0.463397353426493 0.341721071800159 no 1147 0.321539787669543 391 17158655 SGTC_354 2783-3500 4.88 µM 0.460905159144319 0.34258267956087 no 1148 0.322433325086578 337 6740761 SGTC_753 1322-0200 289 µM 0.460685129832552 0.342658788098914 no 1149 0.322512262567261 332 5403907 SGTC_1870 st057514 26.5 µM 0.460256139965311 0.342807194837169 no 1150 0.322666189520015 339 5393161 SGTC_3093 9117344 49.47 µM 0.459659324939209 0.343013700136689 no 1151 0.322880384800302 337 24824913 SGTC_2864 9034755 47.6 µM 0.457894072217603 0.343624773486482 no 1152 0.323514272924664 332 4930451 SGTC_2782 7736369 71.43 µM 0.457353988366414 0.343811814789866 no 1153 0.323708315188104 357 2950836 YOL077C BRX1 SGTC_2566 crystal violet carbinol 226 nM 0.457195374565261 0.343866753029502 no 1154 0.323765311338169 373 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1158 4092-0494 91.8 µM 0.455713772648039 0.344380086891169 no 1155 0.324297908403571 359 1148199 SGTC_667 1498-1044 59 µM 0.454211456889428 0.3449008903845 no 1156 0.324838318850353 371 6739982 SGTC_433 pimozide 108 µM 0.453936162132647 0.344996357929811 no 1157 0.324937387428467 344 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_15 0266-0086 27.098 µM 0.451515599266119 0.345836192232649 no 1158 0.32580899238761 361 1712902 YIL048W NEO1 SGTC_260 nsc-65238 3.989 µM 0.450399418798892 0.346223716260287 no 1159 0.32621123198594 344 3246252 SGTC_275 trichlorophene 5.69 µM 0.447435895811199 0.347253395316772 no 1160 0.327280181498474 347 62616 SGTC_854 0422-0053 192 µM 0.446250164679089 0.347665695321775 no 1161 0.327708275125119 362 3596728 SGTC_2257 7960413 200 µM 0.444288913060223 0.348348053168124 no 1162 0.32841685797311 360 2974689 YIL048W NEO1 SGTC_1180 1193-0155 285 µM 0.444004624562575 0.348447003509737 no 1163 0.328519620200464 362 2921347 SGTC_225 nsc-122657 1.016 µM 0.443554633460549 0.348603649898802 no 1164 0.328682305733095 364 275685 SGTC_2894 9048625 32.47 µM 0.442946280664422 0.348815464614401 no 1165 0.328902295480164 388 4092861 SGTC_397 arbidol 50 µM 0.441953862234462 0.349161103442108 no 1166 0.329261296497997 351 131410 A RNA synthesis inhibitor. SGTC_867 0518-0118 155 µM 0.441015246939708 0.349488118924017 no 1167 0.329600979498006 354 6848158 SGTC_2636 apigenin dimethyl ether 100 µM 0.440893326947203 0.34953060430264 no 1168 0.329645112425329 374 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_808 0711-0032 135 µM 0.44078448952536 0.349568532398956 no 1169 0.329684511692679 382 4252555 SGTC_1643 st009866 20.2 µM 0.440240546010404 0.34975811049287 no 1170 0.329881448169956 345 3156273 YOR207C RET1 SGTC_2480 5767542 37.17 µM 0.438882182394115 0.35023169814365 no 1171 0.330373453888399 373 2867358 SGTC_3165 9101544 49.47 µM 0.43775438767137 0.35062507599928 no 1172 0.330782169421758 369 5002184 SGTC_452 diindolylmethane 8 µM 0.436979649036375 0.3508953998027 no 1173 0.331063053547254 387 3071 Inhibits expression of several cancer promoting factors. SGTC_3194 9111903 49.47 µM 0.436718135442334 0.35098666484901 no 1174 0.331157887666691 397 17087251 SGTC_955 1216-0110 33 µM 0.434401684714869 0.351795452628174 no 1175 0.331998387288069 368 3619719 SGTC_491 tetrandrine 80.3 µM 0.432819724637246 0.352348179247882 no 1176 0.332572871245873 380 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1252 0493-0875 34.8 µM 0.432778480897376 0.352362593721722 no 1177 0.332587854051853 342 3960963 SGTC_604 1000-0114 314 µM 0.432700822447123 0.35238973552411 no 1178 0.332616066125564 369 1572745 SGTC_1070 indatraline 8.81 µM 0.432442066189198 0.35248017684049 no 1179 0.332710074979328 384 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_737 1950-0117 57.9 µM 0.431334713455534 0.352867316485811 no 1180 0.33311250658387 350 5393513 SGTC_2938 9059746 27.26 µM 0.431166667215367 0.352926080164096 no 1181 0.333173594377391 367 6471769 SGTC_583 1488-1091 88.9 µM 0.430236523315157 0.353251403325 no 1182 0.33351179822426 378 4303273 SGTC_2942 9052777 62.25 µM 0.429331077143775 0.353568191352301 no 1183 0.333841151911568 377 6469503 SGTC_1711 st032263 62.8 µM 0.427181705199466 0.354320597005595 no 1184 0.334623492750374 381 3958979 SGTC_1486 3970-0793 4.53 µM 0.425974575698509 0.354743412505172 no 1185 0.335063186063875 388 2844330 SGTC_2859 9028643 45.46 µM 0.425258996760693 0.354994139474338 no 1186 0.335323940353087 342 17151580 SGTC_1236 0330-0013 258 µM 0.424970489127543 0.355095245527121 no 1187 0.3354290939107 373 4617066 SGTC_1328 1441-0025 69.2 µM 0.424412940313817 0.355290664618952 no 1188 0.335632342536578 361 4562601 SGTC_1364 1653-0028 37.6 µM 0.423362140609091 0.355659070008037 no 1189 0.336015531361208 353 5718652 SGTC_953 1188-0045 9.7 µM 0.422877353902027 0.35582907941286 no 1190 0.336192373119801 380 6144426 SGTC_1554 st069299 38.7 µM 0.422330337631074 0.356020946480477 no 1191 0.336391958676316 330 24207999 SGTC_304 1310-0298 97 µM 0.421382378312466 0.356353531470916 no 1192 0.336737942364894 387 1550234 SGTC_2161 5662504 8.5105 µM 0.420813662218355 0.356553114058667 no 1193 0.336945577221123 334 2859334 SGTC_2248 tofa 1.1 µM 0.420695006149963 0.356594759624061 no 1194 0.336988904112419 371 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1885 st057546 99.9 µM 0.420480239183652 0.356670142263443 no 1195 0.337067331096569 359 702008 SGTC_2739 tacrine 100.86 µM 0.419822048414491 0.356901200348661 no 1196 0.337307728348692 361 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_884 0851-0618 334 µM 0.419762519501402 0.356922100583445 no 1197 0.337329473935132 390 9642473 SGTC_1886 st057356 49.9 µM 0.418992685271471 0.357192423307296 no 1198 0.337610739098319 362 24207747 SGTC_108 0509-0257 621.132 µM 0.417548001283629 0.357699908946534 no 1199 0.338138810887123 359 536624 SGTC_215 1287-0124 461.5 µM 0.41701907651211 0.357885771543447 no 1200 0.338332227193583 378 5560863 SGTC_674 0498-0004 451 µM 0.414510978705424 0.358767567728434 no 1201 0.339249964205128 358 4231473 SGTC_2087 5276107 200 µM 0.413675569227541 0.359061448190899 no 1202 0.339555860708434 372 144405 SGTC_482 fipronil 114 µM 0.411104618209946 0.359966380458783 no 1203 0.340497911883169 368 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2529 gangaleoidin 93.61 µM 0.410386803255766 0.360219179935985 no 1204 0.340761112683799 377 4565183 SGTC_716 1683-5115 658 µM 0.408901530254914 0.360742456159643 no 1205 0.341305962991366 396 723597 SGTC_2464 5717415 7.67 µM 0.408528027089435 0.3608740860636 no 1206 0.341443029196262 346 5285744 SGTC_1153 4055-0057 267 µM 0.408188062325861 0.360993910699577 no 1207 0.341567805840406 370 882706 SGTC_1719 st032227 49.2 µM 0.406517428210124 0.361582943680016 no 1208 0.342181227022665 347 3125804 SGTC_2933 9026794 32.47 µM 0.406394884664463 0.361626163077915 no 1209 0.342226238819366 400 17586027 SGTC_3204 9114183 49.47 µM 0.406298638541104 0.361660108979862 no 1210 0.342261592811468 345 17027248 SGTC_1037 k284-1091 78.7 µM 0.405954239189103 0.361781587169473 no 1211 0.342388112003397 342 3334711 SGTC_2828 7998861 71.43 µM 0.405804364545315 0.361834456022507 no 1212 0.342443175758566 347 2988188 SGTC_3077 9117319 49.47 µM 0.404336976777918 0.362352221821548 no 1213 0.34298246892856 375 17154678 SGTC_738 1315-0003 72.4 µM 0.403866958936406 0.362518120295375 no 1214 0.343155277233036 392 6251474 SGTC_1603 st002045 67.8 µM 0.403408578268857 0.362679936155495 no 1215 0.343323838574206 393 5887985 SGTC_2543 pimpinellin 60.67 µM 0.40258539771394 0.362970593893771 no 1216 0.343626626825287 380 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1633 st005664 67.9 µM 0.402448406777038 0.363018971843259 no 1217 0.343677025571976 366 2063822 SGTC_3312 9133330 71.43 µM 0.402384810839038 0.363041431306101 no 1218 0.343700423360339 388 17617324 SGTC_3174 9107204 49.47 µM 0.401935179046311 0.363200236147603 no 1219 0.343865865932469 375 3938802 SGTC_1319 1306-0155 43.7 µM 0.400612733122392 0.363667445249392 no 1220 0.344352634741389 373 3122360 SGTC_1395 3486-0190 4.35 µM 0.399634956963155 0.36401301585633 no 1221 0.344712702652435 386 6748079 SGTC_158 k038-0087 26.446 µM 0.399336413596771 0.364118550622212 no 1222 0.344822669865751 365 X158 SGTC_262 fenpropimorph 62.5 µM 0.398029451521895 0.364580681551516 no 1223 0.345304238162518 383 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_73 0327-0325 16.231 µM 0.397557638388972 0.364747559154188 no 1224 0.345478145846945 343 53298 SGTC_2424 5537928 59.2 µM 0.397450236692952 0.364785550101073 no 1225 0.345517738071516 365 5382802 SGTC_2468 5987765 72.9 µM 0.394856386816016 0.365703468900482 no 1226 0.346474439156962 364 26772094 SGTC_1803 st050068 52.4 µM 0.394059067931705 0.365985781187491 no 1227 0.346768715038417 383 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_720 r052-1644 49.9 µM 0.393841953800628 0.366062668888253 no 1228 0.346848863936244 379 1422863 YOR257W CDC31 SGTC_2365 9042475 200 µM 0.391386028931336 0.366932771566197 no 1229 0.347755958839816 360 6464479 SGTC_2896 9052656 71.43 µM 0.389877070778441 0.367467715646124 no 1230 0.348313724889816 379 6469436 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.389225031363992 0.367698951246971 no 1231 0.348554844098438 390 688669 SGTC_13 0199-0087 65 µM 0.388476690609295 0.367964397727753 no 1232 0.348831650231246 373 4589825 SGTC_2680 butyl paraben 22.24 µM 0.388436147392772 0.367978780751234 no 1233 0.348846649189543 385 7184 An antifungal and steroid mimetic. SGTC_196 k015-0023 18.111 µM 0.387167177961776 0.368429051055886 no 1234 0.349316223575846 364 5211998 SGTC_324 1315-0088 19.6 µM 0.385972461176192 0.368853139393519 no 1235 0.349758532136822 401 6787421 SGTC_1156 4092-0367 4.88 µM 0.384396585025195 0.369412772024912 no 1236 0.35034226561355 372 1357585 SGTC_2192 5915882 198.485 µM 0.38383353881043 0.369612790856754 no 1237 0.350550914104909 371 2876149 SGTC_2961 9083290 32.55 µM 0.383589404094446 0.369699529239371 no 1238 0.350641397323687 373 17741490 SGTC_3157 9099274 49.47 µM 0.383421933835679 0.369759033417128 no 1239 0.350703471430511 403 17217662 SGTC_691 1548-0686 185 µM 0.378830892928609 0.371391495127595 no 1240 0.352406722502658 389 46495133 SGTC_3056 9094900 49.47 µM 0.378293513084116 0.37158272622082 no 1241 0.352606281910486 367 25236784 SGTC_618 k072-0232 33.2 µM 0.377984803183862 0.371692597547664 no 1242 0.352720941638311 404 5872756 YGL099W LSG1 SGTC_192 3455-0609 60.9 µM 0.376716401603557 0.372144137332969 no 1243 0.353192186322899 356 3769639 SGTC_1166 k206-0078 225 µM 0.375849542283974 0.372452832820449 no 1244 0.353514377054677 369 5404595 SGTC_1368 1852-0141 284 µM 0.374450018833426 0.37295138714061 no 1245 0.354034767706449 384 2838987 SGTC_1416 3966-0321 25.3 µM 0.372741443309959 0.373560324031072 no 1246 0.354670444184829 362 582530 YLR208W SEC13 SGTC_516 3992-2719 87.3 µM 0.372685901573106 0.373580124433056 no 1247 0.354691115323894 364 5350887 YDR037W KRS1 SGTC_1400 3771-8998 51.5 µM 0.372536830993646 0.373633269134549 no 1248 0.35474659749525 401 670767 SGTC_1668 st014914 51.6 µM 0.37249111036518 0.373649569339129 no 1249 0.35476361474843 385 2839556 SGTC_1289 0976-0073 69.1 µM 0.372187387708192 0.373757857520904 no 1250 0.354876667911503 394 3391136 SGTC_3282 9108498 15.4605 µM 0.371934263964708 0.373848112962881 no 1251 0.354970896658917 377 16459645 SGTC_325 2810-4341 181 µM 0.371886199386007 0.373865251962116 no 1252 0.354988790352783 376 774970 SGTC_1964 st076914 61 µM 0.370607772723904 0.374321208283298 no 1253 0.355464845963377 420 24208661 SGTC_2072 5231554 129 µM 0.370217677335453 0.37446037250955 no 1254 0.355610153140257 398 789545 SGTC_445 e6 berbamine 66 µM 0.36983697030619 0.374596203264472 no 1255 0.355751983469495 383 6610268 A calcium/calmodulin antagonist. SGTC_2206 7254556 146.969 µM 0.368938643683747 0.374916774851921 no 1256 0.35608672928564 368 4398905 SGTC_330 1488-0319 80.1 µM 0.368412252619724 0.37510465987053 no 1257 0.356282931349848 382 6846614 SGTC_87 0100-0052 35.5 µM 0.368390252584863 0.375112512999236 no 1258 0.356291132265093 384 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_783 0848-0141 92.7 µM 0.36762605785055 0.375385331932547 no 1259 0.356576041053719 411 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2750 bromebric acid 70.15 µM 0.367533968768867 0.375418212116187 no 1260 0.356610379318414 381 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.36733645739354 0.375488736126364 no 1261 0.356684031467835 371 6312947 SGTC_2467 5474540 200 µM 0.367185509356271 0.375542636895273 no 1262 0.356740323714138 362 5413519 SGTC_3136 9095672 49.47 µM 0.366732308268291 0.375704481264053 no 1263 0.356909352320468 367 17217380 SGTC_842 0271-0008 11.1 µM 0.36535342585315 0.37619703362104 no 1264 0.357423801263301 373 1221709 SGTC_209 4077-0173 175.592 µM 0.363912090459463 0.376712110513005 no 1265 0.357961827963284 354 15993494 SGTC_3294 9122953 26.2835 µM 0.360940086119171 0.377774880779713 no 1266 0.35907211813777 402 16459826 SGTC_1316 1272-0050 65.9 µM 0.360614438946853 0.377891386609617 no 1267 0.359193846965602 386 7340392 SGTC_2241 6772625 37.8075 µM 0.360369774478825 0.377978926804176 no 1268 0.359285313388198 374 2285411 SGTC_327 1273-0057 3.96 µM 0.358583662628761 0.378618181703768 no 1269 0.359953285204144 400 3108138 SGTC_2734 clemastine 41.6 µM 0.35855688152051 0.378627769277098 no 1270 0.359963304089722 427 26987 Clemastine is a selective histamine H1 antagonist. SGTC_295 k015-0027 31 µM 0.358503734044427 0.378646796168889 no 1271 0.359983186990259 388 3887424 SGTC_576 1073-0113 22.7 µM 0.355961927483448 0.379557110138066 no 1272 0.360934538804917 413 5439563 SGTC_703 3875-0075 71.8 µM 0.355618852356913 0.379680029176711 no 1273 0.361063011643964 404 2850814 SGTC_137 0438-0332 85.389 µM 0.355516568329621 0.379716678472416 no 1274 0.361101317423745 408 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1569 carminic acid 40.6 µM 0.353105043455517 0.380581062110969 no 1275 0.362004845997859 388 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1176 0848-0131 83.3 µM 0.350590991633308 0.381482830478819 no 1276 0.362947607865807 408 6769040 SGTC_515 4092-1064 102 µM 0.349846155850117 0.38175012038235 no 1277 0.363227078910564 418 717353 SGTC_1047 2043-3044 82 µM 0.349803887781902 0.381765290287408 no 1278 0.363242940566276 421 669592 SGTC_2041 5107442 45.335 µM 0.348554361318173 0.382213824173288 no 1279 0.363711947854696 389 793005 SGTC_1610 st001799 48.1 µM 0.348484025601907 0.382239076805632 no 1280 0.363738354306777 387 621897 SGTC_2826 7992541 19.48 µM 0.347996653275641 0.382414071848043 no 1281 0.363921348450789 436 2985066 SGTC_1949 st076024 69.1 µM 0.345870639161845 0.383177715151903 no 1282 0.364719967478943 421 2921930 SGTC_2904 7225135 42.03 µM 0.345866735719839 0.383179117648384 no 1283 0.364721434314828 421 4446116 SGTC_39 0986-0283 58.349 µM 0.345528092075902 0.383300797248793 no 1284 0.364848697398433 370 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2021 4019055 173 µM 0.345109194758726 0.383451329092457 no 1285 0.365006140605171 385 44827708 YER133W GLC7 SGTC_1270 0831-1170 17.3 µM 0.344212096061185 0.383773763012239 no 1286 0.365343393083502 402 6764716 SGTC_1187 1391-0724 117 µM 0.3434186899369 0.384058994974683 no 1287 0.365641750501934 389 6997986 SGTC_1407 3909-7909 12.3 µM 0.34190122738968 0.384604702293467 no 1288 0.366212612959391 398 4411780 SGTC_164 4100-3994 89.624 µM 0.341326614152241 0.384811403500526 no 1289 0.366428857219617 438 4615967 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.341234317419563 0.384844607749016 no 1290 0.366463595214115 364 6857784 SGTC_3047 9092122 49.47 µM 0.341179139451947 0.384864458724536 no 1291 0.366484363231698 392 17173831 SGTC_172 1112-0046 2.638 µM 0.34021949513075 0.385209751199131 no 1292 0.366845618974934 382 2802135 YIL048W NEO1 SGTC_557 1315-0110 16.2 µM 0.337542825065705 0.386173332057937 no 1293 0.36785386729758 385 6833801 SGTC_2166 5933061 31.504 µM 0.334412705534599 0.387301042110915 no 1294 0.369034076564886 394 2877375 SGTC_2121 5257820 149.641 µM 0.334187605768538 0.387382177172259 no 1295 0.369118998028894 396 791256 SGTC_2284 7945075 39.21 µM 0.333831952665944 0.387510378962224 no 1296 0.369253185253144 429 1245402 SGTC_2247 cerulenin 830 nM 0.33162390923953 0.388306583352671 no 1297 0.370086631678232 375 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2741 miltefosine 3.04 µM 0.331382323134798 0.388393726105657 no 1298 0.370177857706815 423 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2496 diffractaic acid 79.83 µM 0.329859006509708 0.388943332322177 no 1299 0.370753249734418 391 94870 An apoptosis inducer which activates caspases. SGTC_40 0327-0103 19.753 µM 0.328447584052778 0.389452766055739 no 1300 0.371286634876598 395 409036 SGTC_3241 9133421 49.47 µM 0.327780871114747 0.389693473159066 no 1301 0.371538675821128 425 17018221 SGTC_1347 1493-0251 600 nM 0.327581338821485 0.389765519651111 no 1302 0.371614116761715 394 3986378 SGTC_1402 3909-7673 35.9 µM 0.327432116132461 0.389819402985559 no 1303 0.371670539423647 398 5328014 SGTC_280 3448-3607 3.04 µM 0.327123874392947 0.389930713760189 no 1304 0.371787097582242 406 626179 SGTC_2975 9084847 53.72 µM 0.326847383352691 0.390030566555399 no 1305 0.371891659569966 374 27211724 SGTC_890 0929-0006 47.2 µM 0.326455704303556 0.39017203111021 no 1306 0.37203979895151 385 1378169 SGTC_1681 tripelennamine 100 µM 0.325872824208217 0.390382579564937 no 1307 0.37226028874093 360 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1290 0986-0249 10.2 µM 0.321951687307882 0.391799808844901 no 1308 0.373744647632231 418 53329 SGTC_302 1094-0063 18.9 µM 0.321658216457958 0.391905937001961 no 1309 0.373855817632711 405 5440289 SGTC_2140 5586273 200 µM 0.320939630622268 0.392165833861167 no 1310 0.374128070178276 408 854421 SGTC_1479 0549-0158 134 µM 0.320836649933733 0.392203083679508 no 1311 0.374167091895687 375 5440202 SGTC_2324 6149169 200 µM 0.319195064010926 0.392797005624319 no 1312 0.374789299851711 433 2888231 SGTC_24 0417-1663 219 µM 0.319056956913415 0.392846983854845 no 1313 0.374841661279737 408 4329390 SGTC_3034 9090421 49.47 µM 0.318780051169456 0.392947195894976 no 1314 0.374946653277091 425 17173761 SGTC_932 2857-0803 154 µM 0.31869532977259 0.392977857940905 no 1315 0.374978778221028 408 674898 SGTC_3308 9128332 17.569 µM 0.317845364064581 0.393285511017899 no 1316 0.375301119042653 417 17332805 YDL196W YDL196W SGTC_127 0180-0333 59.125 µM 0.317464220927148 0.393423491015562 no 1317 0.375445691984944 380 771601 SGTC_1817 st052116 64.4 µM 0.31660330787519 0.393735204745286 no 1318 0.375772312747231 384 4361398 SGTC_735 3076-0345 636 µM 0.315863767444777 0.394003027063869 no 1319 0.376052957199682 400 2888990 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.315177338854152 0.394251659958941 no 1320 0.376313505182602 387 2333 A French combination drug. SGTC_1480 1070-0044 41.2 µM 0.314293577177057 0.394571832779533 no 1321 0.376649037964916 393 3124987 SGTC_1229 0139-0193 12.2 µM 0.31347525128646 0.394868362775543 no 1322 0.376959810232514 408 3090752 SGTC_803 4488-1585 147 µM 0.313068814022206 0.395015662740616 no 1323 0.377114190891323 432 747204 SGTC_2607 solasodine 47.35 µM 0.312371238608645 0.39526851122491 no 1324 0.377379202907421 392 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_313 3474-0040 5.03 µM 0.311376573499534 0.395629121347628 no 1325 0.377757180482885 403 1043375 YIL048W NEO1 SGTC_3177 9107506 49.47 µM 0.310822914195678 0.395829886086133 no 1326 0.377967624455118 429 8897194 SGTC_68 0986-0284 82.829 µM 0.310170696219032 0.396066425055664 no 1327 0.378215576694336 357 423278 YIL048W NEO1 SGTC_94 0334-0113 514.748 µM 0.309928149457108 0.396154398913667 no 1328 0.378307797952223 434 6795178 SGTC_3132 9126706 49.47 µM 0.308827931910866 0.396553523901977 no 1329 0.378726210224472 438 850858 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.308663473851637 0.396613193537457 no 1330 0.378788765782471 430 368090 SGTC_1264 0783-0040 158 µM 0.307696014837933 0.396964261651618 no 1331 0.379156826204504 419 2855798 SGTC_2387 9077560 195.08 µM 0.306353496420125 0.397451568304062 no 1332 0.379667755820948 395 5303272 SGTC_847 0342-0274 5.54 µM 0.306240278312255 0.397492671485666 no 1333 0.379710853480427 429 18097 SGTC_2791 5663188 71.43 µM 0.304214397198527 0.398228347935658 no 1334 0.380482278477959 454 54690634 SGTC_851 0394-0702 453 µM 0.304186346371031 0.398238536831423 no 1335 0.380492963155033 419 762646 SGTC_2688 kanamycin b 96.69 µM 0.304167218297675 0.398245484756997 no 1336 0.380500249170158 408 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2861 9024595 19.48 µM 0.303761977294484 0.398392688776782 no 1337 0.38065461822291 405 16482810 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.303046019384196 0.398652796214325 no 1338 0.38092739555664 391 5355888 SGTC_442 cape 100 µM 0.302035560952083 0.399019972250557 no 1339 0.381312477196475 421 5281787 SGTC_3344 9148862 3.898 µM 0.301860543117351 0.399083578567397 no 1340 0.38137918774132 412 4905352 SGTC_1094 duloxetine 25.4 µM 0.301104955111169 0.399358210861028 no 1341 0.381667231319964 377 60834 A selective serotonin reuptake inhibitor. SGTC_2434 5670830 169.91 µM 0.300334052223136 0.399638460966249 no 1342 0.381961180749483 416 1549830 SGTC_1759 st043059 70 µM 0.298994398396098 0.400125594828312 no 1343 0.38247215980203 409 669426 SGTC_2000 st075254 36.4 µM 0.298100076842342 0.400450880567995 no 1344 0.382813391461604 394 17234175 SGTC_2858 9025781 8.96 µM 0.295286413579422 0.401474725356313 no 1345 0.383887547219672 418 4894980 YPL153C RAD53 SGTC_2113 5491891 107.031 µM 0.295102898575066 0.401541526968719 no 1346 0.383957637768078 411 789979 SGTC_1679 SEC14.276 6.7 µM 0.294646271521068 0.401707757051556 no 1347 0.384132055456668 442 1005053 YMR079W SEC14 SGTC_193 1273-0060 1.558 µM 0.29139167356268 0.402893071290675 no 1348 0.385375890964506 411 2847393 YHR072W ERG7 SGTC_540 1187-0821 17.3 µM 0.290042355782188 0.403384751033245 no 1349 0.385891917196793 453 847520 SGTC_379 3970-0972 5.9 µM 0.288956142593621 0.403780668759661 no 1350 0.386307469838691 394 2898042 YBL034C STU1 SGTC_1965 Pectolinarigenin 58.4 µM 0.285965433357501 0.404871271406023 no 1351 0.38745229832777 406 5320438 An anti-inflammatory. SGTC_2930 9013230 14.89 µM 0.285476845961349 0.40504951190143 no 1352 0.387639420463422 418 2995857 SGTC_2488 5268135 45.7 µM 0.285338307709 0.40510005532336 no 1353 0.387692483427046 423 1270356 YLR208W SEC13 SGTC_1342 1486-1464 234 µM 0.285156666314835 0.405166326621826 no 1354 0.387762058947144 430 3253938 SGTC_2384 9036245 200 µM 0.283837110171949 0.405647844102681 no 1355 0.388267606883752 420 6462766 SGTC_90 0870-0863 4.608 µM 0.283251559415185 0.405861562441769 no 1356 0.388492003619653 436 1738164 SGTC_719 2810-4230 27.3 µM 0.282925101346671 0.405980727538318 no 1357 0.388617126146823 430 721079 SGTC_1245 0418-0076 17.2 µM 0.28265500158382 0.406079327075178 no 1358 0.388720656800556 427 6790114 SGTC_206 4546-0025 72.014 µM 0.281429573961097 0.406526742435254 no 1359 0.389190468805402 442 6620745 YIL048W NEO1 SGTC_2657 nystatin 74.44 µM 0.280949063158436 0.406702214877377 no 1360 0.389374734268442 410 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_372 0155-0182 15.9 µM 0.28036751619757 0.406914608653877 no 1361 0.389597778175091 414 771486 SGTC_1962 st076595 64.5 µM 0.279932244959347 0.407073597229755 no 1362 0.389764743950649 409 279619 SGTC_1762 st045503 25.4615 µM 0.278528525266622 0.407586428608098 no 1363 0.390303335506722 420 4645554 SGTC_6 0844-0013 19.835 µM 0.278428501860116 0.407622976961052 no 1364 0.390341721419933 432 1584900 SGTC_117 lucigenin 22.078 µM 0.277238228776292 0.408057961997294 no 1365 0.390798593648702 428 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_678 1218-2179 85.9 µM 0.276608182816499 0.408288258064293 no 1366 0.391040490400425 452 6820081 YOR116C RPO31 SGTC_3091 9116372 49.47 µM 0.276072286129057 0.408484165376618 no 1367 0.391246273127313 393 17169793 SGTC_2836 9010338 19.48 µM 0.275202312946737 0.408802249444182 no 1368 0.391580405040097 404 2994051 SGTC_1191 1487-1166 10.6 µM 0.270944101763556 0.410360021416323 no 1369 0.393217012441249 446 3955771 SGTC_3149 9097855 49.47 µM 0.268757680459169 0.411160426612666 no 1370 0.394058080774467 459 25236625 YMR079W SEC14 SGTC_387 norethindrone acetate 66.7 µM 0.268475244373568 0.411263847878509 no 1371 0.394166763878036 431 541197 SGTC_648 0375-0473 33.3 µM 0.26785936557098 0.411489389182077 no 1372 0.39440378631219 438 1713139 SGTC_2432 5630864 12.22 µM 0.267400336676304 0.411657509427732 no 1373 0.394580470121938 429 5714970 SGTC_1218 1348-1416 30.7 µM 0.26607458654814 0.412143159016708 no 1374 0.395090883363273 397 6787668 SGTC_2911 7942208 15.64 µM 0.263050032398942 0.413251618118091 no 1375 0.396256008152432 411 1243384 SGTC_2909 7941780 10.49 µM 0.262683972408321 0.413385821372669 no 1376 0.396397085620706 422 1243215 SGTC_3191 9110352 49.47 µM 0.261952181723091 0.413654137479086 no 1377 0.396679154299518 420 17122424 SGTC_995 3931-2021 34.6 µM 0.260755511337915 0.414092991763358 no 1378 0.39714052728493 429 730143 SGTC_748 act1.228 77.9 µM 0.260302108822784 0.414259295879498 no 1379 0.397315373027417 383 4421505 YNR035C ARC35 SGTC_463 ikarugamyin 104 µM 0.260142231297744 0.414317941239004 no 1380 0.397377031566589 440 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2258 7960471 200 µM 0.25835713723894 0.414972868682854 no 1381 0.398065646701824 462 2974708 SGTC_1775 st081588 35.1725 µM 0.25183022795264 0.417369504494358 no 1382 0.400586145796013 421 1426443 YGL099W LSG1 SGTC_2537 larixol 68.93 µM 0.251492201938768 0.417493709764586 no 1383 0.400716795226832 449 6708759 SGTC_1664 st014217 9.02 µM 0.250859196592369 0.417726325239959 no 1384 0.400961486107765 452 3982782 SGTC_744 1594-0068 283 µM 0.250658926796892 0.417799925962918 no 1385 0.401038909336358 417 668392 SGTC_1648 st011736 69.8 µM 0.249912122171417 0.418074407896574 no 1386 0.401327654244778 429 2855514 SGTC_984 1492-0255 2.91 µM 0.249232483000041 0.418324238406227 no 1387 0.401590477115164 448 1585198 SGTC_1597 7-benzyloxygramine 47.5 µM 0.247708693681813 0.41888449211158 no 1388 0.402179902444077 444 260807 SGTC_2903 5923464 63.88 µM 0.245377700148769 0.419741849717107 no 1389 0.403081997001029 439 2876576 SGTC_2018 5133068 143 µM 0.242165191435775 0.420924059223137 no 1390 0.404326082804614 463 785362 SGTC_1945 st075991 56.6 µM 0.240920333055004 0.421382361929752 no 1391 0.404808431364041 384 1084980 SGTC_1842 st055362 61.2 µM 0.240638657340146 0.421486077477247 no 1392 0.404917593093926 419 676032 SGTC_1972 st070201 17.4 µM 0.239218977523883 0.422008899208468 no 1393 0.405467893935079 446 2829099 SGTC_2629 bisabolol 100 µM 0.238712991355279 0.422195270675128 no 1394 0.405664071152262 464 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2507 purpurin 79.67 µM 0.238643790891133 0.422220760853632 no 1395 0.405690902887813 427 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2849 9019321 12.99 µM 0.23835978488893 0.422325378645348 no 1396 0.405801027799759 427 16489627 SGTC_3140 9094243 49.47 µM 0.237999873638835 0.422457965124642 no 1397 0.4059405961043 453 19291112 SGTC_166 k072-0058 166.424 µM 0.237633843560803 0.422592814709859 no 1398 0.406082549462867 469 5846229 SGTC_72 0744-0168 198.391 µM 0.236834518316587 0.422887326610363 no 1399 0.406392585748298 466 677577 SGTC_255 tunicamycin 200.472 nM 0.236192975489501 0.423123734666767 no 1400 0.406641465042589 442 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_319 1348-1596 45.5 µM 0.234348983829198 0.423803398081804 no 1401 0.407357030441219 450 5380505 SGTC_485 niflumic acid 177 µM 0.234108123882326 0.423892191674975 no 1402 0.407450519610036 443 4488 A COX2 inhibitor. SGTC_2951 9072950 58.06 µM 0.233316372153044 0.424184100040592 no 1403 0.407757873126403 463 16488155 SGTC_902 1120-0002 2.07 µM 0.233134676760689 0.424251094596938 no 1404 0.40782841426102 427 3280475 SGTC_624 k048-0052 28 µM 0.231928053048671 0.424696055214579 no 1405 0.408296947669842 423 6835531 SGTC_839 0122-0028 230 µM 0.231278101616288 0.424935774375988 no 1406 0.408549378961164 459 759448 SGTC_1612 st002233 45.4 µM 0.229309138645874 0.425662148718442 no 1407 0.409314325548003 463 1035021 SGTC_1240 0356-0016 42.1 µM 0.2288795204137 0.425820673722822 no 1408 0.409481279215832 456 4305613 SGTC_2721 ifenprodil 61.44 µM 0.228623373759694 0.425915195086699 no 1409 0.409580828018162 436 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_195 4234-0266 16.654 µM 0.22852865216417 0.425950149635151 no 1410 0.409617642083603 462 2303354 SGTC_174 3553-0389 74.3 µM 0.227352885773305 0.426384084082045 no 1411 0.41007467635336 414 738071 SGTC_2744 captopril 92.04 µM 0.226758230808643 0.426603584503034 no 1412 0.41030587231867 443 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3035 9091303 49.47 µM 0.226355122581625 0.426752393680653 no 1413 0.410462614543478 458 25237002 SGTC_2019 4016004 108 µM 0.225910802208218 0.426916428582498 no 1414 0.410635398026012 419 45595336 SGTC_11 0438-0307 1.3 µM 0.224924572217452 0.427280571661465 no 1415 0.411018976584223 445 4011476 SGTC_3306 9127676 59.7925 µM 0.224849087058954 0.427308445402831 no 1416 0.411048338853266 410 41905287 SGTC_1754 st042065 16.137 µM 0.222593931381024 0.428141353693863 no 1417 0.411925780009775 440 1126236 YIL048W NEO1 SGTC_1458 k015-0034 6.33 µM 0.220617561609416 0.428871559995759 no 1418 0.412695112890601 449 3598957 SGTC_1666 st014829 29 µM 0.220107373617451 0.429060098014762 no 1419 0.412893766155469 441 3858230 SGTC_1971 st069429 63.5 µM 0.219601041999531 0.429247226929063 no 1420 0.413090939910709 465 1246522 YGL099W LSG1 SGTC_2935 9038016 29.96 µM 0.219476860284753 0.42929312416111 no 1421 0.41313930163717 458 6463195 SGTC_444 curcumin 90.4 µM 0.218879189197345 0.429514035168608 no 1422 0.41337207901362 440 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2057 5236571 38.335 µM 0.217396165995651 0.430062284957247 no 1423 0.413949809424929 443 54684039 YBR257W POP4 SGTC_200 k038-0079 37.545 µM 0.21685965756866 0.43026065675797 no 1424 0.41415885900721 449 3436683 SGTC_375 3970-0961 9.27 µM 0.216459233430594 0.430408723423012 no 1425 0.414314899436107 417 2898222 SGTC_2917 7979103 53.79 µM 0.21619077010535 0.430507999815481 no 1426 0.414419523912489 463 2980565 SGTC_1078 idebenone 36.1 µM 0.215439843771252 0.430785711917229 no 1427 0.414712204209724 456 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_916 4466-0038 42 nM 0.213546439285092 0.431486093838535 no 1428 0.415450385520859 470 5722064 YGL116W CDC20 SGTC_1999 st074831 12.5 µM 0.213445356825932 0.431523490937321 no 1429 0.415489802939978 459 17112523 SGTC_2697 mebhydrolin 72.4 µM 0.212328987547749 0.431936550646268 no 1430 0.415925191087252 444 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1503 4585-0012 61.3 µM 0.211254285807926 0.432334263564074 no 1431 0.416344426255364 442 2922052 SGTC_1172 0370-0043 85 µM 0.210701437140943 0.432538882001313 no 1432 0.416560126552604 428 376585 SGTC_1193 1488-0126 41.5 µM 0.210342579345532 0.432671710895147 no 1433 0.416700152521938 430 1384710 SGTC_2156 5649887 115 µM 0.209891846625819 0.432838557476688 no 1434 0.41687604297258 453 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2847 9005661 71.43 µM 0.208857060895849 0.433221646724925 no 1435 0.417279912653231 459 2991449 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.208268643257645 0.433439513526727 no 1436 0.417509606928374 428 3256 An antibiotic and ribosome inhibitor. SGTC_2435 5706476 10.6 µM 0.207886743249925 0.43358092618956 no 1437 0.41765870020269 453 5725375 SGTC_1469 k284-2957 126 µM 0.207552484118416 0.433704705027122 no 1438 0.417789204254991 461 23884841 SGTC_3111 9122088 49.47 µM 0.207059943704862 0.433887108538827 no 1439 0.41798152221407 467 16876704 SGTC_1986 st071812 45 µM 0.206760716879016 0.433997928706544 no 1440 0.418098368283361 473 11838594 SGTC_2890 9046729 58.44 µM 0.206445948032007 0.434114510539281 no 1441 0.418221291209817 442 903329 SGTC_1744 st037937 38.9 µM 0.206435878694671 0.434118240043025 no 1442 0.41822522360004 422 1016152 SGTC_1638 st008370 60.6 µM 0.205349806829631 0.434520536135507 no 1443 0.418649416439021 429 24207134 SGTC_1046 2001-0062 216 µM 0.204455394509795 0.434851889809352 no 1444 0.418998822859655 455 739778 SGTC_205 1486-1330 71.903 µM 0.203930098424043 0.435046518031455 no 1445 0.419204062073039 450 4118834 SGTC_1470 k295-0292 231 µM 0.203356584488067 0.435259029490293 no 1446 0.419428165659505 460 5045612 SGTC_247 mechlorethamine 29.705 µM 0.203286506879064 0.43528499752696 no 1447 0.419455550647204 444 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3169 9102970 49.47 µM 0.202984536396657 0.435396899235564 no 1448 0.419573559390247 447 17027839 SGTC_1897 st060201 15 µM 0.201623030505646 0.43590149887946 no 1449 0.42010571961656 438 611878 SGTC_2416 tofa 880 nM 0.201148595873075 0.436077357822046 no 1450 0.420291192220378 398 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_602 3130-1533 38.1 µM 0.199666035152886 0.436626980705641 no 1451 0.420870889433473 470 720941 SGTC_1005 4092-0690 4.4 µM 0.19859027618297 0.437025868527172 no 1452 0.421291630297491 445 1529343 SGTC_170 4197-0004 226 µM 0.198453939450938 0.43707642631055 no 1453 0.421344959482838 440 218692 SGTC_1 0258-0098 57.368 µM 0.198104420013782 0.437206043380395 no 1454 0.421481683349451 427 6790032 YDR047W HEM12 SGTC_3287 9117173 37.0625 µM 0.19771612184995 0.437350049198303 no 1455 0.421633587651544 457 2789709 SGTC_1424 4048-1941 275 µM 0.197608444792015 0.437389984215604 no 1456 0.421675713554367 482 X1424 SGTC_560 2332-1943 155 µM 0.194780739461011 0.438438944121015 no 1457 0.422782300586897 476 21177716 SGTC_2005 4024620 188 µM 0.194407309284565 0.438577503528511 no 1458 0.422928483561423 485 236743 SGTC_2011 4012611 177 µM 0.19404268756334 0.43871280186707 no 1459 0.42307122861863 458 2049887 SGTC_785 1270-0111 65.3 µM 0.193688378646573 0.438844280346699 no 1460 0.423209946011426 434 6741994 SGTC_2325 6158266 200 µM 0.19355066093123 0.438895387052076 no 1461 0.423263867186324 433 3623240 SGTC_3070 9117005 49.47 µM 0.192759771131774 0.439188904009625 no 1462 0.423573555271167 467 8779016 SGTC_598 3937-0236 20.2 µM 0.192373455767158 0.439332286478763 no 1463 0.42372484164455 467 1379313 SGTC_1729 st035615 45.989 µM 0.190613513825068 0.439985596315989 no 1464 0.424414200909843 436 17385451 SGTC_1764 st044502 93.5 µM 0.189999580052145 0.440213533838767 no 1465 0.424654729803288 431 8407 SGTC_757 1066-0008 322 µM 0.189823298135513 0.440278986360197 no 1466 0.424723799272672 442 6842497 SGTC_1741 st038134 10.228 µM 0.18812032736811 0.44091137395951 no 1467 0.425391163318206 464 1272587 SGTC_2349 9023730 187.07 µM 0.187532236562985 0.441129792911286 no 1468 0.425621675443013 448 4126287 SGTC_3127 9126946 49.47 µM 0.186676241199715 0.441447744524132 no 1469 0.425957242698113 475 27243249 SGTC_1723 st034307 2.5525 µM 0.186158457048015 0.44164008902047 no 1470 0.42616025045749 454 867466 SGTC_2338 7999974 200 µM 0.185826133173446 0.441763546689587 no 1471 0.426290555074168 477 315925 SGTC_2294 7971431 200 µM 0.18538583225499 0.44192712633105 no 1472 0.426463210019537 481 5741572 SGTC_1981 st071826 47 µM 0.18484775103044 0.442127046544324 no 1473 0.426674226632677 438 11838600 SGTC_561 1550-0330 72.9 µM 0.183907216504521 0.442476530763271 no 1474 0.427043121710318 458 6812934 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.182635067835956 0.442949307487779 no 1475 0.427542183472862 479 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_477 mead ethanolamide 10 µM 0.181094700518794 0.443521872700006 no 1476 0.428146622099704 452 16061185 SGTC_1938 st074717 56.4 µM 0.178363474915929 0.444537377386719 no 1477 0.42921876605551 462 17250979 SGTC_2855 9016525 58.44 µM 0.175758627512177 0.445506232438149 no 1478 0.430241787020389 455 43811474 SGTC_626 0214-0009 33 µM 0.175545878641022 0.445585377373374 no 1479 0.430325362240787 463 3437874 SGTC_2288 7946289 167.31 µM 0.175465388811678 0.445615321046508 no 1480 0.430356982283598 464 1246052 SGTC_2705 st078069 42.8 µM 0.175383425893025 0.445645813054321 no 1481 0.430389181481379 456 1530061 SGTC_261 5-fluorouridine 15.376 µM 0.174762468362667 0.445876833340361 no 1482 0.43063314016299 423 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3215 9129942 49.47 µM 0.17349916368936 0.446346888317778 no 1483 0.431129542596126 495 17682944 SGTC_870 0573-2213 57.6 µM 0.173306617279189 0.446418538321894 no 1484 0.431205211280981 469 3916321 SGTC_2670 beta-carotene 100 µM 0.173061180242382 0.446509872421363 no 1485 0.431301669078193 453 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1455 4262-0120 131 µM 0.172484096858962 0.446724632727045 no 1486 0.431528481429427 439 1529587 SGTC_3290 9121031 71.43 µM 0.172291689081623 0.446796240332624 no 1487 0.431604108903638 463 17014854 SGTC_370 0180-0345 38.7 µM 0.171557154865939 0.447069624821601 no 1488 0.431892846706483 433 3989527 SGTC_3115 9123671 49.47 µM 0.169671176651429 0.447771677326131 no 1489 0.432634371529733 491 3286988 SGTC_2359 9039622 200 µM 0.169369410119025 0.447884024699869 no 1490 0.432753041531322 473 6463596 SGTC_2135 5326629 150.42 µM 0.167376606788434 0.44862604790673 no 1491 0.433536865296907 441 5020077 SGTC_207 4185-0010 4.486 µM 0.167046765015811 0.448748882376274 no 1492 0.433666626342861 463 3761753 SGTC_346 4513-0042 7.16 µM 0.161386738067235 0.450857456034242 no 1493 0.435894405622696 442 2827372 SGTC_2710 st078562 53.7235 µM 0.160710551022154 0.451109455185836 no 1494 0.436160689473193 486 17250908 SGTC_1900 st060200 72.8 µM 0.160394857774545 0.451227113455248 no 1495 0.436285020040517 447 688945 SGTC_1876 myriocin 605 nM 0.159293204393611 0.451637731064312 no 1496 0.436718937254304 492 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1202 1988-0068 29.6 µM 0.158222148534819 0.452036993720597 no 1497 0.437140875786493 474 2850480 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.157363858991923 0.45235697748531 no 1498 0.437479047442978 489 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3065 9113888 49.47 µM 0.157354742059716 0.452360376586695 no 1499 0.43748263981911 464 16648368 SGTC_1672 st016598 6.51 µM 0.157180869309157 0.452425202910281 no 1500 0.437551152482641 480 4665860 YNL267W PIK1 SGTC_2983 9022671 12.99 µM 0.155590817905502 0.453018092698981 no 1501 0.438177781522153 480 6405161 SGTC_2045 5106652 78.05 µM 0.15489473497807 0.45327767738964 no 1502 0.438452152215951 495 673349 SGTC_237 nikkomycin 200 µM 0.153651126454454 0.453741496089913 no 1503 0.438942411237803 485 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2478 5763493 32.33 µM 0.152038762147894 0.45434294052699 no 1504 0.439578181621776 467 1365576 YLR208W SEC13 SGTC_3340 9146634 11.102 µM 0.151718689808471 0.454462346470187 no 1505 0.439704407744062 487 4907387 SGTC_2132 5317594 122.667 µM 0.151417968655478 0.454574537024353 no 1506 0.439823007973043 472 794577 SGTC_508 roscovitine 141 µM 0.151199833264561 0.454655919435443 no 1507 0.439909040909274 496 160355 A CDKinase inhibitor. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.150710112570489 0.454838632391618 no 1508 0.4401021978401 484 91467 include heat shock SGTC_147 4466-0538 29.23 µM 0.150394002615045 0.454956576908513 no 1509 0.440226886338595 441 6742687 YHR072W ERG7 SGTC_1827 berberine 7.24 µM 0.150261685457565 0.455005947248823 no 1510 0.440279080152725 482 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1934 st074720 32.6 µM 0.150254781763127 0.455008523182854 no 1511 0.440281803411909 469 17250992 SGTC_1145 3546-0597 10.2 µM 0.150154850744254 0.455045810055405 no 1512 0.440321222921446 444 875334 SGTC_2447 5741742 33.78 µM 0.14994471979965 0.455124216689417 no 1513 0.440404114616605 466 1776504 SGTC_1911 st060208 74.3 µM 0.149855170381378 0.455157630997557 no 1514 0.440439440541195 462 688783 SGTC_3218 9131285 49.47 µM 0.148855450727485 0.455530686070155 no 1515 0.440833847321987 493 17156417 SGTC_3164 9100705 49.47 µM 0.148435172057879 0.455687528853539 no 1516 0.440999672109765 483 17174235 SGTC_18 0111-0177 500 nM 0.148358407477519 0.455716177188829 no 1517 0.441029961394277 467 721752 SGTC_1080 nisoldipine 24.4 µM 0.147789912202068 0.455928345256175 no 1518 0.441254285403803 495 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3327 9140648 26.9345 µM 0.147599013053444 0.455999593530915 no 1519 0.441329617019442 488 8029710 SGTC_3043 9092303 49.47 µM 0.146639319563731 0.456357796221829 no 1520 0.44170835830822 454 25236084 SGTC_3319 9138450 16.7555 µM 0.146517452556226 0.456403285257704 no 1521 0.441756456722157 492 2029690 SGTC_3281 9140613 49.47 µM 0.146086361506367 0.45656420226847 no 1522 0.441926606425184 432 16013766 SGTC_9 0092-0002 10.449 µM 0.145715930201105 0.456702481993618 no 1523 0.442072822560465 477 759368 SGTC_2084 5306078 60.6385 µM 0.145004211805261 0.456968176788364 no 1524 0.442353773199677 485 679340 SGTC_2807 7945238 51.95 µM 0.144424581604212 0.457184575363884 no 1525 0.442582603490472 489 17148797 SGTC_728 3030-5151 22.5 µM 0.142209507886594 0.458011665243802 no 1526 0.443457260956147 464 3125388 SGTC_1531 st059297 52.4 µM 0.141635536719905 0.458226011055653 no 1527 0.443683947820957 479 7566702 SGTC_1787 fluconazole 80 µM 0.141127665815394 0.458415682285574 no 1528 0.443884544108377 476 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3050 9093513 49.47 µM 0.140533392017446 0.458637633858813 no 1529 0.4441192856265 488 25236664 SGTC_3250 9135583 49.47 µM 0.137964073017182 0.459597380137702 no 1530 0.445134405772232 443 7699353 SGTC_1052 3253-3998 198 µM 0.137887488747048 0.459625991153177 no 1531 0.445164669243332 462 5450317 SGTC_1403 3909-7815 62.9 µM 0.137656594076204 0.459712252050582 no 1532 0.44525591281414 494 6615483 SGTC_2473 5854593 8.94 µM 0.137050284580263 0.459938774747219 no 1533 0.445495524357616 459 2872951 SGTC_1863 st057641 20.1 µM 0.136700829727892 0.460069340144368 no 1534 0.445633636831078 503 3921635 SGTC_74 000s-0487 160.283 µM 0.135561607003959 0.460495013129989 no 1535 0.446083929184976 437 677548 SGTC_1706 st031321 9.9705 µM 0.134249289499047 0.46098541943586 no 1536 0.446602725628531 464 6103185 SGTC_1131 3454-3128 32.3 µM 0.133860770269061 0.461130618492924 no 1537 0.446756335909477 460 710982 SGTC_1055 3448-0672 86 µM 0.133470303103228 0.461276550761731 no 1538 0.44691072440224 476 748378 SGTC_1620 st003704 16.5 µM 0.133106674158607 0.461412457267201 no 1539 0.447054508451434 497 2834414 SGTC_513 4245-1575 41.7 µM 0.130708827201845 0.46230876590438 no 1540 0.448002824580741 469 719745 SGTC_1065 prochlorperazine maleate 2.48 µM 0.129618324228991 0.462716456534245 no 1541 0.448434202458118 506 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_134 0269-0018 6.916 µM 0.128675379360119 0.463069013334962 no 1542 0.448807258924681 483 4378915 SGTC_1365 1672-3266 55.4 µM 0.128506184380518 0.463132276569912 no 1543 0.448874202188125 492 6415873 SGTC_1442 4112-3290 3 µM 0.128309688829216 0.463205748857561 no 1544 0.448951948954293 495 704353 SGTC_2481 5478948 45.16 µM 0.127405179971367 0.463543972840318 no 1545 0.449309858314074 485 77792 SGTC_3036 9090181 49.47 µM 0.12739352909697 0.463548329636904 no 1546 0.449314468772998 481 25236586 SGTC_421 streptovitacin 30 mM 0.127381176139428 0.46355294897937 no 1547 0.449319357066226 461 91467 include heat shock SGTC_1340 1486-1359 257 µM 0.127254737404909 0.463600230555684 no 1548 0.4493693916486 483 4309068 SGTC_2541 muurolladie-3-one 83.07 µM 0.126371689466222 0.463930459313582 no 1549 0.449718855500787 491 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1977 st070720 65.3 µM 0.125922470903685 0.464098460749867 no 1550 0.449896647524516 462 682188 SGTC_582 0987-0078 156 µM 0.125732948452847 0.464169341407808 no 1551 0.449971659865814 501 1625765 SGTC_2408 sulbentine 18.36 µM 0.12522633953451 0.464358816745401 no 1552 0.450172182720248 444 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1225 1216-0074 20.6 µM 0.125194941952184 0.464370559930876 no 1553 0.4501846107391 483 4241466 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.124587784620374 0.46459765233328 no 1554 0.450424949751566 461 688664 SGTC_911 3456-4043 236 µM 0.123922874513351 0.464846358981206 no 1555 0.450688170653069 471 914281 SGTC_2648 atorvastatin 78.68 µM 0.123867353651506 0.464867126933573 no 1556 0.450710150924684 499 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1645 Cervolide 78 µM 0.123556903511479 0.464983254661802 no 1557 0.450833058472173 478 23173 A fragrance. SGTC_2711 st079103 59.1 µM 0.12127717432203 0.465836106387789 no 1558 0.451735749403529 500 54693780 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.120442503105899 0.466148398185709 no 1559 0.452066311914514 497 551469 SGTC_2805 7950783 58.44 µM 0.120300762752684 0.466201432340261 no 1560 0.452122449956126 473 1178958 YDL195W SEC31 SGTC_696 1560-0013 611 µM 0.120286669729009 0.466206705476884 no 1561 0.452128031726949 472 1650269 SGTC_3345 9148410 3.559 µM 0.119528051746942 0.466490563603915 no 1562 0.452428508629863 509 4903596 SGTC_1332 1480-0653 17.5 µM 0.118089572121422 0.467028857659978 no 1563 0.452998342939709 509 5749438 SGTC_1371 2421-0008 32.7 µM 0.117567651114113 0.467224180898245 no 1564 0.453205118905062 489 2827552 SGTC_758 0868-0029 16 µM 0.117341453545779 0.467308835322673 no 1565 0.453294738365816 471 762687 SGTC_584 0986-0246 15.4 µM 0.117329920555897 0.467313151582995 no 1566 0.453299307799372 504 53315 YDR232W HEM1 SGTC_460 trequinsin 123 µM 0.116926074233802 0.46746429484973 no 1567 0.4534593178118 497 5537 A vasodilator. SGTC_374 0880-0231 82.3 µM 0.114904824468551 0.468220836554708 no 1568 0.454260280526789 498 6833587 SGTC_1010 4112-3296 15.2 µM 0.114810560754443 0.468256121722003 no 1569 0.454297639070966 500 704384 SGTC_2916 7875993 68.79 µM 0.114758775387496 0.468275506332079 no 1570 0.454318162791669 501 1299250 SGTC_907 3448-6986 75.5 µM 0.114302141197273 0.468446439639838 no 1571 0.454499142597782 474 590582 SGTC_968 1309-0633 340 µM 0.114158123621785 0.468500351398436 no 1572 0.454556223668379 505 3761976 SGTC_1923 st058458 19.1 µM 0.11409211082147 0.468525062923797 no 1573 0.454582388020096 506 3534982 SGTC_1309 pyrazolanthrone 13.4 µM 0.112613793038874 0.469078494569229 no 1574 0.455168374676086 507 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2171 5739187 198.077 µM 0.111779598199206 0.469390815042813 no 1575 0.455499082204459 496 2262761 SGTC_2341 7987486 176.74 µM 0.110914136024577 0.469714861833552 no 1576 0.455842217920925 511 1258686 SGTC_2731 amoxapine 43.43 µM 0.110711520930209 0.469790727986677 no 1577 0.455922554883089 512 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2370 9071495 200 µM 0.108691900638181 0.470547003713603 no 1578 0.456723433074371 501 21791103 SGTC_2280 7785178 200 µM 0.10779219821442 0.470883944533829 no 1579 0.457080265876685 484 2954328 SGTC_1279 0874-0590 65.2 µM 0.106322980920928 0.471434214808495 no 1580 0.457663049397889 482 3523074 SGTC_2188 6126565 140.678 µM 0.106168013917169 0.471492258254112 no 1581 0.45772452433888 494 874518 SGTC_3229 9132204 49.47 µM 0.105030570872545 0.471918310069381 no 1582 0.458175775411718 503 17682924 SGTC_2271 7849410 118.62 µM 0.104594369738889 0.472081706392997 no 1583 0.458348841249045 501 972430 SGTC_1505 k297-0037 20.6 µM 0.104590153409617 0.472083285808248 no 1584 0.458350514145629 459 4089396 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.100937149787287 0.473451844438262 no 1585 0.459800176212617 451 6708561 SGTC_2628 lathosterol 100 µM 0.100571024255716 0.473589026989041 no 1586 0.459945499673878 474 6710616 SGTC_2139 5578692 56.4705 µM 0.100235973154325 0.473714569093619 no 1587 0.460078493684268 506 650991 YMR113W FOL3 SGTC_1578 josamycin 24.2 µM 0.0992018654050895 0.474102060913039 no 1588 0.46048899689366 481 5282165 A P450 substrate. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0985167855746919 0.47435878155671 no 1589 0.460760971917105 492 390807 SGTC_3170 9103054 49.47 µM 0.0969048515760653 0.474962864992586 no 1590 0.461400977971295 499 16432970 SGTC_2844 9010103 25.97 µM 0.0959144122050467 0.475334067648984 no 1591 0.461794274035203 504 2480525 SGTC_1567 st069303 68.4 µM 0.0943622719178318 0.475915830803351 no 1592 0.46241069234238 509 5581319 SGTC_1126 isoteolin 1.0172 µM 0.0936594743214318 0.476179265801657 no 1593 0.462689831759664 480 133323 SGTC_1627 st003713 25.6 µM 0.0917984137545276 0.476876911354886 no 1594 0.463429102191282 501 16195070 YER133W GLC7 SGTC_3239 9133757 49.47 µM 0.0911528581558005 0.477118923902202 no 1595 0.463685566342363 507 17036923 SGTC_1253 0550-0034 176 µM 0.0910721392302566 0.477149185241728 no 1596 0.463717635148553 496 5969915 SGTC_727 3032-0951 202 µM 0.0907724761038592 0.4772615294098 no 1597 0.463836690314107 504 3652836 SGTC_495 decylubiquinone 155 µM 0.0906555317571031 0.477305372516411 no 1598 0.463883152794046 511 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_424 splitomicin 100 mM 0.0904605123599772 0.477378487018128 no 1599 0.46396063591462 492 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_895 0964-0006 13.7 µM 0.0899550690042252 0.477567985753377 no 1600 0.464161459875902 513 6738897 SGTC_250 brefeldin a 552.239 µM 0.0875239503558413 0.478479520826181 no 1601 0.465127524423767 518 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3112 9123419 49.47 µM 0.0874976816626232 0.478489370757088 no 1602 0.465137964065379 509 17015854 SGTC_381 3461-2219 42.7 µM 0.0862880759455893 0.478942948859287 no 1603 0.465618708569201 508 2883159 SGTC_1710 st031758 61.5 µM 0.0855028123687057 0.479237421728849 no 1604 0.465930829857178 515 5394341 SGTC_1563 conessine 56.1 µM 0.0852575666849031 0.479329390886766 no 1605 0.466028312766637 522 441082 An anti-amoebic, histamine inhibitor. SGTC_3220 9131269 49.47 µM 0.0848859330796962 0.479468758655374 no 1606 0.466176037598114 519 17722206 SGTC_2830 7992007 71.43 µM 0.0848441844291217 0.479484415136897 no 1607 0.466192633031442 515 1952075 SGTC_2187 6125751 200 µM 0.0843390548385232 0.479673850158638 no 1608 0.466393430864575 504 874498 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0839742650524019 0.479810657436875 no 1609 0.466538446497345 500 688761 SGTC_2032 5185112 25.99 µM 0.0838456206941724 0.479858903556718 no 1610 0.466589587813763 515 5718189 SGTC_3298 9116858 71.43 µM 0.0820605998123302 0.480528378766834 no 1611 0.4672992621038 509 2506942 SGTC_2576 guaiol 23.12 µM 0.0818908634623161 0.480592041571745 no 1612 0.467366749968955 489 227829 SGTC_2037 5169046 200 µM 0.0816853763703802 0.480669114025881 no 1613 0.467448453730011 489 5718022 SGTC_273 hydroxyurea 18.1 mM 0.081407416167807 0.480773370263753 no 1614 0.467558975719765 510 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1943 st076331 65.2 µM 0.0804942373744471 0.481115891053393 no 1615 0.467922089636829 525 24208415 SGTC_1021 4476-0760 85.3 µM 0.0803016249986165 0.481188139091969 no 1616 0.46799868291385 492 746768 SGTC_2290 7904846 200 µM 0.0797497349864796 0.481395153974527 no 1617 0.468218151294955 491 2962154 SGTC_344 k064-0035 6.43 µM 0.0787903259372496 0.481755041850383 no 1618 0.468599699454852 508 5088750 SGTC_1771 st048882 4.1505 µM 0.0784364266797666 0.481887798226461 no 1619 0.468740449237023 512 4580403 SGTC_3003 9075612 71.4286 µM 0.0781958242573899 0.481978055301611 no 1620 0.468836141804268 512 6501993 SGTC_1658 st012944 20 µM 0.0776453717190482 0.482184549773693 no 1621 0.469055074943163 511 24207260 SGTC_3240 9133527 49.47 µM 0.0774857006437354 0.482244449012431 no 1622 0.469118583152565 510 17617455 SGTC_1755 st041960 45.185 µM 0.0770219292339118 0.482418431159535 no 1623 0.469303049889851 516 2257073 SGTC_2956 9076196 2.52 µM 0.07627431956348 0.482698901226245 no 1624 0.469600428166446 530 16423868 SGTC_1676 st018489 23.4 µM 0.0752646014677318 0.48307771634135 no 1625 0.470002092752278 526 3696235 SGTC_25 0118-0223 35.662 µM 0.0752472759102408 0.483084216490926 no 1626 0.470008985104764 510 5333628 SGTC_2300 7976697 71.57 µM 0.0748006926627087 0.483251765772094 no 1627 0.470186645349164 518 2236109 SGTC_2662 daunorubicin 22.37 µM 0.0730874396168729 0.483894571913312 no 1628 0.470868268330012 513 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2013 4024628 200 µM 0.0727905981688379 0.48400595001703 no 1629 0.470986376342301 502 5230760 SGTC_1444 4112-3581 28 µM 0.0724021486764328 0.484151702327975 no 1630 0.471140937444014 513 2877249 SGTC_2802 7925815 54.55 µM 0.0717104052589137 0.484411260482999 no 1631 0.471416187642404 501 1262923 SGTC_203 k066-0004 30.888 µM 0.0691838066513042 0.485359354111414 no 1632 0.47242165632041 511 6795412 SGTC_3346 9158254 43.5805 µM 0.0686526719409811 0.485558670491928 no 1633 0.472633045793086 517 17639500 SGTC_2593 nobiletin 86.24 µM 0.067957654927551 0.485819491641743 no 1634 0.472909671394949 510 72344 An anti-infammatory. SGTC_1636 st007707 68.9 µM 0.0670754939753733 0.486150551589157 no 1635 0.47326080146172 522 403051 SGTC_2643 anethole 100 µM 0.0648344203849961 0.486991630653581 no 1636 0.47415291779424 518 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_496 calpeptin 138 µM 0.0641501571091141 0.487248447630538 no 1637 0.474425332230532 522 73364 A calpain inhibitor. SGTC_774 k060-0086 136 µM 0.0637394781377931 0.487402585778581 no 1638 0.474588834816667 526 5911235 SGTC_3023 9089636 49.47 µM 0.0636563012041715 0.487433804403886 no 1639 0.474621950362184 531 17249241 SGTC_2756 carbadox 75.1 µM 0.0620458043119256 0.488038283797773 no 1640 0.475263177838248 525 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_52 0329-0193 875 nM 0.0617174710859022 0.488161522888903 no 1641 0.47539391328874 524 3739292 SGTC_3279 9140807 49.47 µM 0.0615015524499802 0.488242568049343 no 1642 0.475479889036189 526 45595718 SGTC_3209 9113616 49.47 µM 0.0604352901451739 0.488642797155849 no 1643 0.475904476270839 519 16649353 SGTC_1546 5-methoxyflavanone 78.7 µM 0.0596074908821905 0.488953525378078 no 1644 0.47623412605924 517 147795 SGTC_2264 7948757 110.76 µM 0.0593645981429678 0.489044700488547 no 1645 0.476330854948876 520 2971411 SGTC_2358 9037157 4 µM 0.0580465391096616 0.489539472680125 no 1646 0.476855779073115 527 2388925 SGTC_2420 aureobasidin a 50 nM 0.0567961978925448 0.490008839889584 no 1647 0.477353771346608 469 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2269 7935389 174.42 µM 0.0565064902570494 0.490117595612313 no 1648 0.477469162655334 505 97605 SGTC_2674 ligustilide 100 µM 0.0558625986253077 0.490359313986444 no 1649 0.477725633126624 522 5319022 A signalling regulator. SGTC_1022 4477-0945 21.3 µM 0.0558481813894701 0.490364726290226 no 1650 0.477731375806499 496 4648966 SGTC_1984 st072354 53.1 µM 0.0551293291708263 0.490634589304243 no 1651 0.478017715184472 509 5762938 SGTC_1628 st004252 77.7 µM 0.0540821599743387 0.49102771283993 no 1652 0.478434852860903 522 692968 SGTC_472 calcifediol 10 µM 0.0537615807540133 0.491148065004769 no 1653 0.478562559672418 524 5283731 A vitamin D metabolite. SGTC_2080 5212524 12.4 µM 0.0523627286050511 0.491673232735063 no 1654 0.479119835809619 527 260183 SGTC_1385 3091-4834 14.1 µM 0.0518118086207577 0.491880067324747 no 1655 0.47933932313593 511 4072814 SGTC_1288 0973-0013 65.5 µM 0.0497690411727573 0.492647012137069 no 1656 0.480153218831277 530 4315430 SGTC_2505 galangin 7.89 µM 0.0496662949900849 0.492685588318101 no 1657 0.480194157998728 529 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2007 4011539 71.82 µM 0.04880866571769 0.49300758892048 no 1658 0.480535888081619 514 45595301 SGTC_2100 5377183 190 µM 0.047067099820395 0.493661481132755 no 1659 0.481229874401888 529 2844202 SGTC_2459 5811157 9.22 µM 0.0458635380502706 0.49411338317478 no 1660 0.481709507999906 531 2870684 YBR192W RIM2 SGTC_3273 9137859 49.47 µM 0.0455001681501253 0.494249819395005 no 1661 0.481854320437253 530 2377234 SGTC_856 0433-0016 11.3 µM 0.044705518198091 0.494548192704237 no 1662 0.482171017605823 512 3911780 SGTC_1740 st038286 13.222 µM 0.0445506479371706 0.494606343388679 no 1663 0.482232740404611 526 716786 SGTC_1017 4239-0030 168 µM 0.0442285371993074 0.494727289891844 no 1664 0.482361117454661 530 1149593 SGTC_1239 0337-0584 35.4 µM 0.0436295354828381 0.4949522050122 no 1665 0.48259985409842 527 914301 YML130C ERO1 SGTC_3176 9106582 49.47 µM 0.0414391541906883 0.495774669654628 no 1666 0.483472899530369 529 17018027 SGTC_1231 0242-0792 125 µM 0.0413417541665265 0.495811242760204 no 1667 0.483511723248049 528 3707635 SGTC_3350 9150499 3.57 µM 0.0377270474641659 0.497168565011409 no 1668 0.484952655292946 534 4910996 YPR165W RHO1 SGTC_130 0136-0219 337.655 µM 0.0367058723653642 0.497552022847064 no 1669 0.485359763164817 535 234244 SGTC_963 1269-2853 151 µM 0.0353017133780601 0.4980792972237 no 1670 0.485919578552874 524 3668223 SGTC_119 0121-0043 24.815 µM 0.0348768212630101 0.498238848752322 no 1671 0.486088981659442 523 1092378 SGTC_2623 humulene 100 µM 0.0341501808128672 0.498511710643381 no 1672 0.486378696648284 530 6187145 An anti-inflammatory. SGTC_1913 st060213 96.1 µM 0.0337600369865955 0.498658214456713 no 1673 0.486534251815563 516 688959 SGTC_3038 9091290 49.47 µM 0.0330129477993261 0.498938756138864 no 1674 0.486832131209595 542 25236843 SGTC_896 0964-0007 44.5 µM 0.0329523114457935 0.498961525901168 no 1675 0.486856308460509 519 6756758 SGTC_665 3914-0008 307 µM 0.0320289358654629 0.49930826616452 no 1676 0.487224487623384 520 1069549 SGTC_693 4161-2696 114 µM 0.0307054098529931 0.499805269278345 no 1677 0.487752238379735 536 805759 SGTC_1339 1486-1321 22.7 µM 0.0303621646543001 0.499934162883328 no 1678 0.48788910958315 519 3469382 SGTC_3197 9113331 49.47 µM 0.0300115146279395 0.499934162883328 no 1679 0.48802893498144 528 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2793 7325131 81.82 µM 0.029942181295689 0.499908127199472 no 1680 0.488056582554107 529 4176441 SGTC_2399 5884133 200 µM 0.0299200154195402 0.499899803587729 no 1681 0.488065421499122 528 722445 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0292012123317254 0.499629882525191 no 1682 0.488352057173193 538 115019 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0286219817899559 0.499412373110568 no 1683 0.488583040165918 528 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3211 9128781 49.47 µM 0.0275941983615829 0.499026426094823 no 1684 0.48899290447091 520 17194361 SGTC_2063 5246145 200 µM 0.0273753610396076 0.49894424973289 no 1685 0.489080174962139 537 711240 SGTC_1032 k061-1018 98.7 µM 0.0265977985332312 0.498652264925073 no 1686 0.489390264577884 516 4005393 SGTC_2381 9035592 200 µM 0.0261852133518712 0.498497334120581 no 1687 0.489554804937717 521 4749657 SGTC_1397 3532-0190 20.1 µM 0.0259098881548459 0.498393946251177 no 1688 0.489664606544188 530 5322280 SGTC_671 0560-0003 407 µM 0.0256052144161822 0.498279537783119 no 1689 0.489786113466141 532 3238678 SGTC_97 0535-0701 19.132 µM 0.0250005183736299 0.498052467942133 no 1690 0.490027275068221 518 2832013 YGL099W LSG1 SGTC_1763 st044482 94.5 µM 0.02487831748149 0.498006580272478 no 1691 0.490076011012152 541 88505 SGTC_2023 5144124 124 µM 0.0231150092798079 0.497344443465707 no 1692 0.490779266605648 539 2830192 SGTC_1337 1486-1011 40.3 µM 0.0222587174332477 0.497022901324477 no 1693 0.491120789715954 537 X1337 SGTC_1473 k844-0725 134 µM 0.0220065483326532 0.496928210845713 no 1694 0.491221365994891 536 54682906 SGTC_303 1348-1668 34.2 µM 0.0217597251782399 0.496835527958108 no 1695 0.491319810612727 538 5380509 SGTC_2469 5655019 90.81 µM 0.0213612176819449 0.496685887475387 no 1696 0.491478755153714 538 2788239 SGTC_2519 cryptotanshinone 88.04 µM 0.0211666501453256 0.496612827085355 no 1697 0.49155635882392 540 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2058 5236698 133 µM 0.0204181641748535 0.496331770606994 no 1698 0.491854896977252 537 766665 SGTC_2124 5246320 200 µM 0.0200404469382618 0.496189938468945 no 1699 0.492005553522718 529 579342 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0189895549033091 0.49579533300363 no 1700 0.492424718944227 536 7104 SGTC_3195 9113082 49.47 µM 0.0187841118647271 0.495718190489804 no 1701 0.492506664241629 544 17018038 SGTC_2194 5927483 104.545 µM 0.0187342583828071 0.49569947085828 no 1702 0.492526549404219 534 760979 SGTC_3187 9109394 49.47 µM 0.0177864966296735 0.49534359483994 no 1703 0.492904588592934 538 17098090 SGTC_3089 9117425 49.47 µM 0.0173864304226868 0.49519337467151 no 1704 0.493064167237352 541 9401657 SGTC_877 0771-0151 33.1 µM 0.0169066206461447 0.495013212628778 no 1705 0.493255555505466 534 6166523 SGTC_2972 9093619 59.92 µM 0.0165289007644161 0.494871384666184 no 1706 0.493406222879545 537 25236256 SGTC_798 1287-0182 476 µM 0.0161292948506346 0.49472133954376 no 1707 0.493565621320619 532 1649755 SGTC_1446 4239-0190 62 µM 0.0148134160048184 0.494227255145619 no 1708 0.494090518166077 542 1340085 SGTC_1452 4194-0072 190 µM 0.0145357146115885 0.494122985310606 no 1709 0.494201293064872 535 1343545 SGTC_698 k064-0052 127 µM 0.014363876276587 0.494058464571582 no 1710 0.494269839485511 542 5088751 SGTC_358 0075-0058 9.45 µM 0.0138601331013543 0.493869323266447 no 1711 0.494470783924545 542 1069125 SGTC_1453 4237-0541 195 µM 0.0134717920837434 0.493723513143919 no 1712 0.494625695108542 540 739892 SGTC_1003 4049-0218 100 µM 0.0126182881263146 0.493403051601168 no 1713 0.494966164942686 539 295161 SGTC_688 0527-0193 473 µM 0.0125041962277302 0.49336021431372 no 1714 0.495011677434126 543 4007154 SGTC_3141 9094609 49.47 µM 0.0119327300737085 0.493145651074673 no 1715 0.495239642424505 541 25236309 YDL196W YDL196W SGTC_2025 5147754 141 µM 0.0108916118274224 0.492754756944531 no 1716 0.495654961447123 544 315777 YLR208W SEC13 SGTC_3180 9109287 49.47 µM 0.00969791153158218 0.492306583546834 no 1717 0.49613115370239 541 18891271 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.00898341096382197 0.492038329743676 no 1718 0.496416185747675 540 1609 A potent and irreversible inhibitor of serine proteases. SGTC_927 2425-1185 123 µM 0.00882959790234004 0.491980582266605 no 1719 0.496477545847349 535 730375 SGTC_683 panaxydol 45 µM 0.00855123306889802 0.491876073580381 no 1720 0.496588593155018 540 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1223 0764-0573 147 µM 0.00809754171611356 0.491705741886306 no 1721 0.496769583545332 545 1609797 SGTC_2664 lyso-paf C-16 73.48 µM 0.00796298460907337 0.491655224704183 no 1722 0.496823262333649 542 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2523 spermine 47.74 µM 0.00771973833863922 0.491563902360578 no 1723 0.496920300571897 537 1103 A DNA binding polyamine. SGTC_1836 st055642 81 µM 0.00729100333841635 0.491402942760443 no 1724 0.497091336271925 545 8571 SGTC_376 3970-0862 59.1 µM 0.00694016182469485 0.491271227683037 no 1725 0.497231298241463 545 3135186 SGTC_1807 st050092 58.9 µM 0.00684965543233781 0.491237249370811 no 1726 0.497267404209764 538 5008496 SGTC_1038 k292-0204 154 µM 0.00601861469152036 0.49092525936482 no 1727 0.497598934626037 542 4454212 SGTC_1937 st074714 47.2 µM 0.00540780082141141 0.490695950642938 no 1728 0.497842610123584 538 17250970 SGTC_3329 9141233 27.5565 µM 0.00471943167414977 0.490437530191792 no 1729 0.4981172261549 545 4909101 YNL103W MET4 SGTC_865 0488-0499 301 µM 0.00377174352883887 0.490081765463946 no 1730 0.498495295603183 547 9634651 SGTC_2051 5263410 176 µM 0.00245937989528265 0.489589113647271 no 1731 0.499018850365291 546 227584 SGTC_815 1582-0027 36.9 µM 0.00238920379429462 0.489562770487179 no 1732 0.499046846496774 546 3128206 SGTC_2612 dictamnine 15.46 µM 0.00186777007284902 0.489367032747481 no 1733 0.499254867981112 547 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_236 1509-0011 5.31 µM 0.00177325758407761 0.489331554568891 no 1734 0.499292572946413 546 3107280 SGTC_942 3253-1115 227 µM 0.000916026942830108 0.489009770489559 no 1735 0.499634558173626 546 46497897 SGTC_3071 9117417 49.47 µM 0.00068428283658658 0.488922780460524 no 1736 0.499727010666037 547 45595590 YGL055W OLE1 SGTC_2165 5727197 32.143 µM -0.000313874512936349 0.488548107160654 no 1737 0.499874782188105 549 1361712 SGTC_2002 4023503 131 µM -0.00156499973805875 0.488078492894817 no 1738 0.499375655690531 551 4736863 YCR052W RSC6 SGTC_770 0389-1121 67.2 µM -0.00183358883206304 0.48797767916393 no 1739 0.499268504299905 550 6753108 SGTC_2820 7989630 71.43 µM -0.00203707946783522 0.487901300363121 no 1740 0.499187323433803 551 2984098 SGTC_3266 9136860 49.47 µM -0.00365090046949357 0.487295579770388 no 1741 0.498543504676805 550 4871271 YPR165W RHO1 SGTC_657 3534-0529 86.7 µM -0.00510162765742285 0.486751098672583 no 1742 0.497964753857017 553 1049549 SGTC_1382 3002-2117 298 µM -0.00544256498612724 0.486623142990939 no 1743 0.497828741432534 551 1497314 SGTC_1814 st052110 31.539 µM -0.00556417682528376 0.486577501721734 no 1744 0.497780226062828 553 674163 SGTC_609 0986-0026 86.3 µM -0.0056754498615378 0.486535740788686 no 1745 0.497735835245008 553 2848610 SGTC_1530 rhein 70.4 µM -0.00612240419412002 0.486367999667047 no 1746 0.497557529368128 550 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_390 dec-rvkr-cmk 16.7 µM -0.00689356328366052 0.486078590796393 no 1747 0.497249887924987 555 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2028 5153890 36.43 µM -0.00689721731928093 0.486077219487969 no 1748 0.497248430210338 552 2830968 YPR165W RHO1 SGTC_2200 6600604 21.907 µM -0.0071592288828329 0.485978890645613 no 1749 0.497143905301566 552 2904777 SGTC_537 1334-0398 209 µM -0.00865520383015705 0.485417491150696 no 1750 0.496547116357433 561 5846986 SGTC_2834 9001755 58.44 µM -0.00963168578022132 0.485051059041181 no 1751 0.496157572720747 561 2989575 SGTC_1704 st028805 70.8 µM -0.0106785690785086 0.484658222331872 no 1752 0.495739948264137 553 2876101 SGTC_2 0422-0095 29 µM -0.0109479121430748 0.484557155347479 no 1753 0.495632502209885 538 6790840 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0110518757417914 0.484518144816265 no 1754 0.495591029243895 559 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1241 0364-0022 50.8 µM -0.0112070568847431 0.484459916068664 no 1755 0.495529124758932 553 4563895 SGTC_846 0335-0850 148 µM -0.0120726238793455 0.484135134769117 no 1756 0.495183836890651 555 6819598 SGTC_2380 9035439 200 µM -0.0126071150189239 0.48393458623851 no 1757 0.494970622013098 556 6462575 SGTC_1125 tnp00248 1.32998 µM -0.0130548987211527 0.483766574674361 no 1758 0.494791996867853 553 24207736 SGTC_1113 artemisinin 1.17947 µM -0.0138318759192467 0.483475054274514 no 1759 0.494482055828681 560 2240 An anti-malaria and mitochondrial poison. SGTC_1992 st073643 23.3 µM -0.0159977783641949 0.482662458828942 no 1760 0.493618082038746 557 3161292 SGTC_3307 9126885 69.2785 µM -0.017259837551217 0.482188997018861 no 1761 0.493114662908929 558 24824909 SGTC_1545 lovastatin 49.4 µM -0.0185901928561482 0.48168994111074 no 1762 0.492584013226318 558 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2996 9066192 71.4286 µM -0.0187724107115596 0.481621587981209 no 1763 0.492511331503393 559 6472854 SGTC_2899 9053889 58.44 µM -0.0191242692165686 0.481489601184396 no 1764 0.492370985466903 554 6470052 SGTC_3353 9151644 39.2805 µM -0.0194568444456415 0.481364849665381 no 1765 0.492238331831425 563 4909158 SGTC_1237 0330-0133 46.1 µM -0.0194919445888209 0.481351683438734 no 1766 0.492224331555331 564 X1237 YHR072W ERG7 SGTC_948 3448-0295 75.3 µM -0.0197765893173522 0.481244912632283 no 1767 0.492110796624829 559 678569 SGTC_1000 4048-0884 8.67 µM -0.0200750359929612 0.481132966132832 no 1768 0.491991757261847 562 13040088 SGTC_2879 9041815 71.43 µM -0.0209206400066371 0.480815790580555 no 1769 0.491654480941043 556 4942971 SGTC_2788 5282734 71.43 µM -0.0211226554334778 0.480740018895262 no 1770 0.491573906251455 559 743706 SGTC_3175 9106517 49.47 µM -0.0211850938425825 0.480716599718093 no 1771 0.491549002502814 561 41468073 SGTC_1301 naphtanilide LB 4.81 µM -0.0212527969808486 0.480691205940184 no 1772 0.491521998938225 568 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1500 4488-1866 171 µM -0.0215394415491558 0.48058369349935 no 1773 0.491407670473304 557 2900003 SGTC_1302 1159-0335 255 µM -0.0216263008059665 0.480551115275588 no 1774 0.491373026713153 558 649284 SGTC_3101 9120531 49.47 µM -0.0227599396935933 0.480125934343481 no 1775 0.490920881616637 558 24824904 SGTC_525 k781-2675 26.7 µM -0.0228048302089289 0.48010909823511 no 1776 0.490902977539125 554 3651118 YDL195W SEC31 SGTC_1383 3049-0032 20.7 µM -0.0231312698616689 0.479986668689902 no 1777 0.490772781306051 573 712864 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0233586309538614 0.479901399173783 no 1778 0.490682101855272 555 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_419 nsc-638432 893 µM -0.0249814965711972 0.479292786509897 no 1779 0.490034861300098 566 368090 SGTC_2616 abietic acid 100 µM -0.0260539995032486 0.478890599165772 no 1780 0.489607133836351 559 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1761 st044296 37 µM -0.0266320540364059 0.47867383828043 no 1781 0.489376603448649 560 1826700 SGTC_3083 9117465 49.47 µM -0.0282871714979588 0.478053231724172 no 1782 0.488716556084298 564 16420915 SGTC_145 3737-0113 38.366 µM -0.0284436178831332 0.477994572965863 no 1783 0.488654168110294 566 6849351 SGTC_585 0kpi-0023 191 µM -0.0285226957139997 0.477964923325829 no 1784 0.488622633414618 557 64601 SGTC_2863 9028737 58.44 µM -0.0289535541760322 0.477803378321359 no 1785 0.488450816723193 565 6460917 SGTC_888 0916-0002 6.97 µM -0.0290106329170086 0.47778197763261 no 1786 0.488428055161537 568 2802138 YIL048W NEO1 SGTC_1893 st059353 36.1 µM -0.0302600187892544 0.477313558120872 no 1787 0.487929841171845 568 3112488 SGTC_2704 st078022 71.1 µM -0.0303582601978548 0.477276726791505 no 1788 0.487890666518196 569 54697681 SGTC_480 am 92016 50 µM -0.0308436892530302 0.477094739204171 no 1789 0.487697098997286 564 2129 K+ channel blocker. SGTC_1448 4255-0083 152 µM -0.0315576487422837 0.476827084136976 no 1790 0.48741240898057 569 5399660 SGTC_2127 5253358 187.912 µM -0.0316140435776666 0.476805942816279 no 1791 0.487389921916426 563 20612 SGTC_2111 5486399 200 µM -0.0316165951078198 0.476804986299076 no 1792 0.487388904511758 563 689674 SGTC_1908 st060353 56.5 µM -0.0318383384559606 0.476721859700374 no 1793 0.487300486228512 572 4227716 SGTC_190 3970-0790 3.722 µM -0.0325657190622648 0.476449188185588 no 1794 0.487010453773668 562 2832352 SGTC_106 0092-0003 11.579 µM -0.0326860221777147 0.476404091489405 no 1795 0.486962485311228 567 1072148 SGTC_689 0833-0039 98 µM -0.0327886061633927 0.476365637205811 no 1796 0.486921582146551 564 5374726 SGTC_3131 9127911 49.47 µM -0.0343855168516946 0.475767053307796 no 1797 0.486284866260517 576 45595681 SGTC_1596 piperlongumine 63 µM -0.0345097366389167 0.475720493201428 no 1798 0.486235339129495 576 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_607 4491-0986 66.8 µM -0.035111199330057 0.475495057434446 no 1799 0.485995535572772 567 698981 YDR232W HEM1 SGTC_3335 9143315 29.6265 µM -0.0374888182917309 0.474603973489615 no 1800 0.485047627795783 565 4899691 SGTC_1039 k821-0043 94 µM -0.0385233780955295 0.474216280605525 no 1801 0.484635196145648 559 15992768 SGTC_642 0335-0876 158 µM -0.038825601149181 0.474103029562638 no 1802 0.484514716727099 563 6812350 SGTC_3212 9128307 49.47 µM -0.0389926954466353 0.474040415768363 no 1803 0.484448106187771 592 27243542 SGTC_2336 9001819 198.65 µM -0.0406301145777089 0.473426874095411 no 1804 0.483795388005698 559 2989602 SGTC_118 0083-0097 135.343 µM -0.0406900013588725 0.473404435677974 no 1805 0.483771516377585 570 5207356 SGTC_3004 9076122 71.4286 µM -0.0408125161103618 0.473358532035567 no 1806 0.483722680630024 577 44782551 SGTC_862 0452-0056 10.2 µM -0.0413993122220686 0.473138677068621 no 1807 0.483488780547978 561 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2768 sulfasalazine 50.2 µM -0.0425218802990482 0.472718107213456 no 1808 0.483041334783362 573 5384001 An antioxidant and salicylic acid derivative. SGTC_2761 levamisole 97.89 µM -0.0426352201842612 0.47267564613575 no 1809 0.482996159679401 564 26879 An alkaline phosphatase inhibitor. SGTC_1651 st011928 86.1 µM -0.0438948211917934 0.472203776635252 no 1810 0.482494121707076 566 720198 SGTC_357 1325-0123 420 µM -0.0451476535074057 0.471734481505574 no 1811 0.481994809057977 583 1098503 SGTC_1930 st074634 34.3 µM -0.0454755026946782 0.471611679801025 no 1812 0.48186415035528 580 684253 YOR116C RPO31 SGTC_1605 st000082 49.1 µM -0.0458481704314648 0.471472093795231 no 1813 0.481715632350393 596 1114022 SGTC_2781 5567276 71.43 µM -0.0480180006650692 0.470659434785184 no 1814 0.480850948348976 580 2853274 SGTC_2404 5161160 200 µM -0.0491707267157827 0.470227757763357 no 1815 0.480391619867257 576 2831543 SGTC_3232 9132874 49.47 µM -0.0494701810413548 0.470115622728516 no 1816 0.480272300087581 570 3784940 SGTC_2112 5488546 200 µM -0.0501038588015633 0.469878340683772 no 1817 0.480019812361741 577 600757 SGTC_1306 1185-0270 9.02 µM -0.0506099849356096 0.469688828307939 no 1818 0.47981815309772 573 1548076 SGTC_2968 9090663 33.37 µM -0.0511608656075593 0.469482565980224 no 1819 0.479598667852501 585 25236811 SGTC_849 0386-0493 241 µM -0.0519760811474834 0.469177345672596 no 1820 0.479273876062819 573 726119 SGTC_2199 6590217 200 µM -0.0526205361366355 0.468936071681445 no 1821 0.479017127083212 577 703109 SGTC_1421 4029-0249 71.4 µM -0.054306328759912 0.468304991142823 no 1822 0.478345553687469 576 2894095 SGTC_872 0588-0139 234 µM -0.0550651431378238 0.468020953044966 no 1823 0.478043282869396 568 2047100 SGTC_1212 0520-0165 585 µM -0.0552546046303495 0.467950036677831 no 1824 0.477967813568897 585 5403258 SGTC_1107 amlodipine 47 µM -0.0557473146194074 0.467765617676621 no 1825 0.477771553233069 582 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3208 9114115 49.47 µM -0.0558304162452412 0.467734513814777 no 1826 0.477738452033111 579 650895 SGTC_1112 tnp00069 1.16933 µM -0.0580177937366676 0.466915878166934 no 1827 0.476867227523869 567 145826 SGTC_1379 2144-0755 36.5 µM -0.0597389318504502 0.466271832852584 no 1828 0.47618178197849 577 5392327 SGTC_2673 kobusone 100 µM -0.0611012768236057 0.46576210951286 no 1829 0.475639276147278 571 6710676 An epoxy ketone and protein crosslinker. SGTC_1412 3909-8563 178 µM -0.0646549999058528 0.464432745314813 no 1830 0.474224346342381 593 23767530 SGTC_3286 9117135 37.221 µM -0.0647047576257717 0.464414134905613 no 1831 0.474204537362799 566 3438150 SGTC_500 h-89 112 µM -0.0657408291473399 0.464026640625891 no 1832 0.473792082872736 587 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3356 9151811 4.48 µM -0.0660015960501836 0.463929118275795 no 1833 0.473688277381504 569 1859254 YPR165W RHO1 SGTC_1440 4100-1550 40 µM -0.0664395296666545 0.463765343491886 no 1834 0.473513949794052 589 742806 SGTC_448 monastrol 171 µM -0.0665267853805686 0.463732713055936 no 1835 0.473479216645894 576 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1349 flufenamic acid 69 µM -0.0679542137999674 0.463198941993606 no 1836 0.472911041040064 586 3371 A non-steroidal anti-inflammatory. SGTC_360 0957-0399 1.01 µM -0.0683867816356446 0.463037201073782 no 1837 0.472738871961268 594 6752301 YPR165W RHO1 SGTC_1810 st050138 53 µM -0.0688516430871404 0.462863392099144 no 1838 0.472553855173233 579 3444541 SGTC_2137 5261020 140 µM -0.068959266453741 0.462823153362064 no 1839 0.472511021469147 587 763655 SGTC_1201 1889-3372 45.9 µM -0.0698616308581366 0.4624857880651 no 1840 0.472151896309328 581 5392199 SGTC_1915 st067105 30.6 µM -0.070050328900018 0.462415243283461 no 1841 0.472076800660314 575 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2316 5844804 197.44 µM -0.0700982338971541 0.462397334183611 no 1842 0.472057736196142 602 776813 SGTC_1195 1502-0147 41.1 µM -0.0706760142779342 0.462181339214013 no 1843 0.471827805461059 579 817940 SGTC_3117 9124945 49.47 µM -0.0709384198404965 0.462083246309054 no 1844 0.471723382885968 575 17592065 SGTC_3029 9088683 49.47 µM -0.0712298797857295 0.461974294947732 no 1845 0.471607400588399 582 25236615 SGTC_2107 5363541 170.161 µM -0.0719532646744054 0.461703897003918 no 1846 0.47131955039054 573 244052 SGTC_499 genistein 192 µM -0.0727762368509827 0.461396295320506 no 1847 0.470992090523907 580 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2886 9058944 51.95 µM -0.0780868288521142 0.459411922684058 no 1848 0.468879492127553 572 4949929 SGTC_2921 7974240 10.71 µM -0.0793947027001491 0.458923371608468 no 1849 0.468359340987768 592 2979074 YDR527W RBA50 SGTC_681 1642-0006 26.6 µM -0.080112199347752 0.45865537989192 no 1850 0.46807401012917 579 4446530 SGTC_1611 st001856 99.4 µM -0.0802066597680187 0.458620099437543 no 1851 0.468036446750172 585 647478 SGTC_2693 st077581 40.7 µM -0.0814539338518343 0.458154280008224 no 1852 0.467540479275139 604 25238761 SGTC_2243 6634756 200 µM -0.0832944697251618 0.457467000259447 no 1853 0.466808698767715 577 885676 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0844860534562141 0.457022115271286 no 1854 0.466334995462299 659 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2128 5255449 168.493 µM -0.0847417482372605 0.456926657078796 no 1855 0.466233352512545 584 736008 SGTC_1557 sumaresinolic acid 42.3 µM -0.0857170179383344 0.456562583804166 no 1856 0.465845686780555 584 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2077 5212015 200 µM -0.0857943455858127 0.456533718545448 no 1857 0.465814950737576 577 780900 SGTC_2079 5212404 121 µM -0.0868054714081802 0.456156301504358 no 1858 0.465413069244399 590 758462 SGTC_2160 5660466 132.927 µM -0.0870981708622974 0.456047054652931 no 1859 0.465296739651259 617 2859134 SGTC_666 0272-0154 136 µM -0.0876920191977751 0.455825417512436 no 1860 0.465060731472501 586 6870312 SGTC_810 3825-7150 143 µM -0.0878239059928525 0.455776196349309 no 1861 0.465008318471165 580 22330411 YGL099W LSG1 SGTC_3323 9138564 53.9225 µM -0.0899888190504233 0.454968331761972 no 1862 0.464148049941875 586 43912313 YNL103W MET4 SGTC_2597 laccaic acid a 100 µM -0.0912150514477048 0.454510830080362 no 1863 0.463660857742477 613 5491415 A textile dye. SGTC_608 k048-0125 159 µM -0.091451020335299 0.454422798075231 no 1864 0.463567111595332 586 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2595 hexamethylquercetagetin 100 µM -0.0919559922212733 0.454234417683293 no 1865 0.463366502253055 615 386331 SGTC_3005 9076496 71.4286 µM -0.0922018719110639 0.454142695682254 no 1866 0.463268825406111 590 21368410 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0926400428952229 0.453979248151533 no 1867 0.463094765443741 603 6728940 SGTC_3092 9117248 49.47 µM -0.0940550075843612 0.453451488184669 no 1868 0.462532730312548 581 17141857 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0948470718024496 0.453156096293799 no 1869 0.462218148740399 573 66535 A nucleotide analog. SGTC_1757 st041620 31.8375 µM -0.0962217864904138 0.45264347275586 no 1870 0.461672213989857 588 5289815 SGTC_3016 9080866 49.47 µM -0.0969476407649236 0.452372837475822 no 1871 0.461383987552378 598 17066299 SGTC_453 enantio-paf c16 10 µM -0.0979973842003497 0.451981479064841 no 1872 0.46096718523846 617 13871343 A lipid and platelet activating factor SGTC_988 1497-1057 103 µM -0.0989915053532864 0.451610900392103 no 1873 0.460572507361172 591 3533044 SGTC_546 peri-Naphthalide 147 µM -0.0990165395740122 0.451601568925246 no 1874 0.460562568978619 586 223824 A penicillin ester. SGTC_873 0591-4978 488 µM -0.0995340404565466 0.451408677273376 no 1875 0.460357130853423 587 3305145 SGTC_272 doxorubicin 8.13 µM -0.100152685458709 0.451178100539146 no 1876 0.460111554304112 596 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_492 tmb-8 126 µM -0.101935296690637 0.450513791410524 no 1877 0.459404016582953 619 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2034 5197015 53.07 µM -0.103188794671127 0.450046744883275 no 1878 0.458906566496957 613 780676 SGTC_3049 9092223 49.47 µM -0.103260806046138 0.450019915931859 no 1879 0.458877990763428 618 8623917 SGTC_1861 st057647 17.4 µM -0.103336584189371 0.449991683859352 no 1880 0.458847920520985 583 688668 SGTC_2773 thioridazine 9.09 µM -0.10393877831153 0.449767338095219 no 1881 0.458608966554926 592 5452 An antipsychotic. SGTC_1139 k015-0024 46.9 µM -0.104476265208131 0.449567112387022 no 1882 0.458395701403826 626 2766652 SGTC_450 aminopyrene 156 nM -0.104666782943162 0.449496143413781 no 1883 0.458320110258502 593 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1571 st070080 73.4 µM -0.104784225891922 0.44945239603155 no 1884 0.458273513525856 595 4315245 SGTC_2348 9022543 33.42 µM -0.105577220018245 0.449157022610379 no 1885 0.457958899754657 607 3162678 YDL140C RPO21 SGTC_659 k018-0002 107 µM -0.105974996228784 0.449008870045019 no 1886 0.457801095285476 611 6797879 YHR007C ERG11 SGTC_2745 rifampicin 24.3 µM -0.107848881478817 0.448311033613128 no 1887 0.457057783587793 584 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_898 1000-0849 28.3 µM -0.107947070415107 0.448274472361692 no 1888 0.457018839225342 588 6751807 SGTC_1916 st067606 49.2 µM -0.109688699834316 0.44762603928304 no 1889 0.456328131281151 595 19590279 SGTC_972 1319-0219 195 µM -0.110777795711403 0.447220624609289 no 1890 0.455896276708592 587 23903702 SGTC_3202 9113761 49.47 µM -0.111374148856552 0.446998656181197 no 1891 0.455659829365265 599 4798415 SGTC_81 0411-0046 9.971 µM -0.112459260600321 0.446594809694939 no 1892 0.455229635053574 593 12925265 SGTC_490 phenamil 164 µM -0.112478207007714 0.446587758893383 no 1893 0.455222124184444 593 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_709 3807-1509 243 µM -0.115879442387933 0.445322283532553 no 1894 0.453874044260073 610 1886677 YPL242C IQG1 SGTC_749 1000-0129 128 µM -0.116005421115473 0.445275422070027 no 1895 0.453824122688468 620 708470 SGTC_985 1493-0307 8.71 µM -0.116680634641038 0.445024269751429 no 1896 0.45355656837867 619 3278274 SGTC_544 k015-0020 52.4 µM -0.117098165757842 0.444868975976566 no 1897 0.453391131625373 583 3008304 SGTC_822 1487-0950 154 µM -0.117225436280541 0.44482164149773 no 1898 0.453340705321392 595 1958375 SGTC_2882 9058044 58.44 µM -0.117657035263075 0.444661126978151 no 1899 0.453169705568202 616 18076804 SGTC_2102 5377816 72.7585 µM -0.118886714957094 0.444203850803034 no 1900 0.452682553519408 597 1379702 SGTC_2303 7774051 200 µM -0.119203093986915 0.444086212158687 no 1901 0.452557227740992 611 2953184 SGTC_3326 9140064 16.379 µM -0.119473812393962 0.443985555331992 no 1902 0.452449993048224 615 1868434 SGTC_2431 5490079 200 µM -0.1196560723722 0.443917790600384 no 1903 0.452377799715479 627 5722345 SGTC_2808 7946468 45.46 µM -0.120281616504479 0.443685224156393 no 1904 0.452130033140867 644 2970879 SGTC_1587 estradiol valerate 56.1 µM -0.120602205023429 0.4435660424246 no 1905 0.452003061118732 594 13791 A steroid. SGTC_2203 7227154 166.4 µM -0.121004395931064 0.443416531474013 no 1906 0.451843776666443 598 896304 SGTC_2999 9069765 71.4286 µM -0.122121715922516 0.443001219880292 no 1907 0.451401311890318 602 2097066 SGTC_2251 lansoprazole 556 µM -0.122510090942182 0.442856874223011 no 1908 0.451247527387692 639 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3087 9117406 49.47 µM -0.123497382320888 0.442489966112207 no 1909 0.450856623515116 591 42546093 SGTC_423 5-fluorouracil 457 µM -0.123546558480663 0.442471692012302 no 1910 0.450837154162339 598 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_101 0490-5701 117.494 µM -0.123820047329269 0.442370064461702 no 1911 0.450728879244084 602 4661669 SGTC_2920 7982904 15.77 µM -0.126557306196532 0.441353118148875 no 1912 0.449645394931585 616 6456808 SGTC_1725 st036284 20.55 µM -0.128294455947231 0.440707932399186 no 1913 0.448957976181884 619 707914 SGTC_939 1165-0479 45.3 µM -0.128648469336846 0.440576469374527 no 1914 0.448817905979925 615 1377347 SGTC_413 propylparaben 100 µM -0.130287544359625 0.439967883743101 no 1915 0.448169467116468 607 7175 A pharmaceutical preservative. SGTC_1570 verbenone 133 µM -0.131725266050498 0.439434176946393 no 1916 0.447600800117599 612 29025 A natural terpanoid with antifungal properties. SGTC_2950 9072895 21.46 µM -0.132241319450403 0.43924263592206 no 1917 0.447396709946897 619 17332245 SGTC_2299 7976368 114.88 µM -0.132419626062879 0.439176458030332 no 1918 0.447326196008439 613 2979718 SGTC_1262 0737-0114 49.6 µM -0.133323054238674 0.438841179906179 no 1919 0.446968947854913 604 765919 SGTC_1118 chelidonine 707.474 nM -0.13351211103711 0.438771023139036 no 1920 0.446894193398326 603 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1594 piperine 70.1 µM -0.133563362864992 0.438752004516372 no 1921 0.446873928371446 604 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_122 0236-0016 402.397 µM -0.134657176839179 0.438346143797919 no 1922 0.446441466327765 608 6808838 SGTC_208 k072-0098 12.366 µM -0.134996005820473 0.438220434113699 no 1923 0.446307516158804 599 5948901 SGTC_505 gw-5074 63.9 µM -0.135187187160296 0.438149506255195 no 1924 0.446231938630347 607 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2363 9053361 176 µM -0.138505710018155 0.43691866004362 no 1925 0.444920378585159 628 6469797 YMR079W SEC14 SGTC_1733 st037357 54.9 µM -0.140609050094182 0.436138842629673 no 1926 0.444089399166604 642 1272339 YGL099W LSG1 SGTC_692 k241-0027 77.8 µM -0.142698585413348 0.435364389078991 no 1927 0.443264116980683 598 3600480 SGTC_393 acivicin 6.25 µM -0.143357938565908 0.435120061459716 no 1928 0.443003749976634 627 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1765 st044815 90.4 µM -0.144266864925624 0.434783293483524 no 1929 0.442644871255197 609 645695 SGTC_2181 6316240 54.2555 µM -0.145216857033249 0.4344313607288 no 1930 0.442269828511144 619 12779990 SGTC_2827 7993847 71.43 µM -0.14710916866931 0.433730492677048 no 1931 0.441522926532745 616 2985692 SGTC_179 1273-0063 6.77 µM -0.148047156967193 0.433383160792031 no 1932 0.441152776192837 651 3108139 SGTC_2405 ticlatone 3.52 µM -0.148306886699924 0.433286993390245 no 1933 0.441050290331589 633 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_957 1187-1561 14.1 µM -0.148741163832949 0.43312620698133 no 1934 0.44087893923436 615 1538454 SGTC_935 2996-0153 430 µM -0.150311477824946 0.432544907785632 no 1935 0.440259438938105 613 23738523 SGTC_415 dibenzyl ketone 100 µM -0.150614536480768 0.432432738227324 no 1936 0.440139896878204 615 7593 SGTC_308 4092-1169 104 µM -0.15104536192787 0.432273288371642 no 1937 0.439969966360282 615 2268590 YDL196W YDL196W SGTC_1106 tegaserod maleate 11.7 µM -0.151049514961506 0.432271751374441 no 1938 0.439968328332631 615 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1357 1503-1303 39.5 µM -0.151801904872193 0.431993316150358 no 1939 0.439671589838807 610 292895 SGTC_2690 usnic acid 100 µM -0.151928860727238 0.431946337212493 no 1940 0.4396215224764 647 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2883 9059145 45.46 µM -0.152067356573951 0.431895089096103 no 1941 0.439566905208697 605 16476510 SGTC_2959 9079155 11 µM -0.152197170776039 0.431847054520473 no 1942 0.439515712681575 616 16189457 SGTC_3275 9138069 49.47 µM -0.152898431212968 0.431587587660656 no 1943 0.439239186537245 605 17617007 SGTC_2312 7706453 155.7 µM -0.153104423443925 0.431511375992043 no 1944 0.439157963801814 634 976098 SGTC_2868 9035608 32.47 µM -0.153875361342214 0.431226172039937 no 1945 0.438854005753646 597 6462614 SGTC_876 0720-0963 56.8 µM -0.155557547358607 0.430603981864069 no 1946 0.4381908948923 680 765861 SGTC_3355 9151058 44.0485 µM -0.156458080888279 0.430270972188936 no 1947 0.437835979434801 603 17015728 SGTC_2838 9002687 71.43 µM -0.156476537689204 0.430264147537997 no 1948 0.437828705820115 641 6457060 SGTC_2652 actinonin 100 µM -0.15658388042005 0.43022445652925 no 1949 0.437786403690908 602 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1739 st037196 92.5 µM -0.157239861940057 0.429981916376732 no 1950 0.43752790686901 634 612214 SGTC_936 3005-4620 401 µM -0.157442310646257 0.429907069080365 no 1951 0.437448135081007 638 777207 SGTC_2439 5492030 7.2 µM -0.157733942110585 0.429799254461506 no 1952 0.437333226673883 628 5722370 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.158305275862248 0.429588050558891 no 1953 0.437108125514638 663 688798 SGTC_1266 0828-0227 32.9 µM -0.158512284240251 0.429511531120775 no 1954 0.437026570806532 627 3913820 SGTC_1713 st033146 12.748 µM -0.161535265875115 0.428394406772722 no 1955 0.435835918954306 661 674619 SGTC_2819 7996655 46.38 µM -0.162256027408035 0.428128138104552 no 1956 0.435552120396445 639 6456960 SGTC_1783 st039459 87.517 µM -0.162647791501065 0.427983423645123 no 1957 0.435397877901838 628 729761 SGTC_1002 4049-0206 172 µM -0.162912016107663 0.42788582669947 no 1958 0.435293854869499 606 4662749 SGTC_1604 st002052 72.4 µM -0.163205963032533 0.42777725637142 no 1959 0.435178135669176 610 6254834 YHR062C RPP1 SGTC_150 3970-0969 77.2 µM -0.163295886520593 0.427744043907503 no 1960 0.435142736257157 618 6615640 SGTC_1871 st057448 67.3 µM -0.16345242705368 0.427686228234693 no 1961 0.435081113521853 626 691747 SGTC_2986 9022445 71.43 µM -0.164478301249623 0.427307376948819 no 1962 0.434677313602575 621 6459286 SGTC_2352 9027995 87.8 µM -0.164546183633822 0.427282310613203 no 1963 0.434650596446968 627 2997347 SGTC_1343 1487-0095 224 µM -0.165614465213266 0.42688787432456 no 1964 0.434230181454936 655 4560101 YGL055W OLE1 SGTC_1941 st076221 61.8 µM -0.166044802511311 0.426729003657361 no 1965 0.434060846109589 607 2828568 SGTC_910 3454-3003 490 µM -0.166078327844215 0.426716627371583 no 1966 0.434047654584242 641 820824 SGTC_1008 4106-0037 6 µM -0.167451568599121 0.42620974093006 no 1967 0.43350737602535 635 2905394 SGTC_1377 2944-0135 198 µM -0.167489534927159 0.426195728642336 no 1968 0.433492440570051 630 1894137 SGTC_2913 7966556 36.57 µM -0.169032072506358 0.4256265010499 no 1969 0.432885707076564 629 2976516 SGTC_556 4058-0063 51.5 µM -0.171876129188922 0.424577393662589 no 1970 0.431767456720623 639 6615692 SGTC_2667 digitoxin 100 µM -0.172599585930373 0.424310611949042 no 1971 0.431483088696325 617 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2776 terbinafine 19.92 µM -0.173139165914917 0.424111659147479 no 1972 0.431271019933513 592 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2105 5350118 200 µM -0.174509542495658 0.423606463802085 no 1973 0.430732516003115 627 2133313 SGTC_67 0335-0847 266 µM -0.17531610377792 0.423309180080766 no 1974 0.430415629374081 690 4552207 YOR254C SEC63 SGTC_2076 5212012 200 µM -0.17769013890737 0.422434408167145 no 1975 0.429483165009377 620 604802 SGTC_2601 securinine 100 µM -0.178006277320392 0.42231794791678 no 1976 0.429359022943324 618 442872 A GABA receptor antagonist. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.178208214419345 0.422243561127176 no 1977 0.429279729406123 656 165506 SGTC_429 1112-0049 25.5 µM -0.178897752614385 0.421989579523814 no 1978 0.429008993736881 612 2836170 SGTC_1338 1486-1223 76 µM -0.181042709724904 0.421199722904117 no 1979 0.428167026186033 638 3444526 SGTC_2369 9071472 200 µM -0.183466349786907 0.420307626007909 no 1980 0.427216059795955 621 17296037 SGTC_714 4296-0578 26.1 µM -0.184265737274008 0.420013475839993 no 1981 0.426902495674477 614 1589775 SGTC_218 alverine citrate 93.75 µM -0.184450125310962 0.419945633011807 no 1982 0.426830175004832 630 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1788 fluconazole 20 µM -0.185322489653789 0.419624691846564 no 1983 0.426488049677607 613 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_646 4092-0839 27.3 µM -0.18643433783028 0.419215722547588 no 1984 0.426052083372597 637 877796 SGTC_86 0417-1630 471.922 µM -0.187161863717577 0.418948165092274 no 1985 0.4257668623885 621 3634867 SGTC_2699 st077704 54.6 µM -0.187879090782679 0.418684431857266 no 1986 0.425485716992329 638 645852 SGTC_2608 thymoquinone 42.66 µM -0.188525350172389 0.418446825607029 no 1987 0.425232422612903 614 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3268 9137683 49.47 µM -0.194565404214844 0.416227565631723 no 1988 0.422866594424428 636 1953228 SGTC_2539 epi(13)torulosol 80 µM -0.195106030327886 0.416029055755758 no 1989 0.422654970890402 665 6708597 SGTC_1647 st011722 22.4 µM -0.197212910927208 0.415255645360622 no 1990 0.42183046378184 647 2854783 SGTC_337 1315-0038 354 µM -0.197392792186348 0.415189628292444 no 1991 0.421760084831356 655 1626437 SGTC_633 0437-0093 97.7 µM -0.197505408331408 0.415148298981384 no 1992 0.421716024781087 635 2831118 SGTC_1060 3448-7350 82 µM -0.197719663189885 0.415069671590138 no 1993 0.421632202207839 655 570178 SGTC_2702 st077768 96.8 µM -0.198324804559725 0.414847614787088 no 1994 0.421395472942111 614 6484119 SGTC_3017 9080681 49.47 µM -0.198393112743123 0.414822550786609 no 1995 0.421368752793692 640 16451914 SGTC_1522 st012842 45.6 µM -0.199028879481523 0.414589288532006 no 1996 0.421120076965569 643 3491067 YOR116C RPO31 SGTC_3184 9108758 49.47 µM -0.199351882182065 0.414470790658401 no 1997 0.420993748707411 618 902885 SGTC_804 1595-0054 20.9 µM -0.199974901646925 0.4142422496057 no 1998 0.42075010511313 667 761523 Stimulates phospholipase C. SGTC_1684 st024538 14.6195 µM -0.200127918742378 0.414186123072052 no 1999 0.42069026951127 623 6732859 SGTC_1081 sertraline 6 µM -0.20086523624843 0.413915700257749 no 2000 0.420401975562684 634 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2965 9082772 38.63 µM -0.201108209462731 0.413826594937389 no 2001 0.420306981457299 632 16459634 SGTC_1466 k213-0079 57.5 µM -0.20114645078059 0.413812571141663 no 2002 0.420292030850079 644 3657981 SGTC_274 sirtinol 40.1 µM -0.202910368834341 0.4131658296461 no 2003 0.41960254485594 633 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_231 b-estradiol 524 µM -0.203977269567947 0.412774764141731 no 2004 0.419185630866017 631 450 A steroid. SGTC_3039 9090270 49.47 µM -0.204646527824862 0.412529496045356 no 2005 0.418924150344604 613 17173750 SGTC_222 nsc-310342 10.666 µM -0.205034304450014 0.412387400255364 no 2006 0.418772661630438 633 432556 SGTC_389 tpck 16.7 µM -0.205438906523504 0.412239151236244 no 2007 0.418614612730621 648 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_707 0865-0008 204 µM -0.20619884761535 0.41196073738686 no 2008 0.418317793988022 635 723043 SGTC_2062 5245942 200 µM -0.207619810766683 0.411440268891665 no 2009 0.417762917332208 629 1376160 SGTC_404 fumagillin 50 µM -0.207696497571767 0.411412184573689 no 2010 0.417732976290462 639 12015870 A methionine aminopeptidase binder. SGTC_2083 5306046 65.942 µM -0.208361468146926 0.411168677436909 no 2011 0.417473370000984 649 539837 SGTC_2598 perillyl alcohol 100 µM -0.208452586766512 0.411135313159426 no 2012 0.417437799847834 637 10819 An apoptosis inducer. SGTC_1516 st013856 110 µM -0.209439982669042 0.410773806472524 no 2013 0.417052391572022 664 5281404 A mutagen and neurotoxin. SGTC_2589 lobaric acid 100 µM -0.211357113512808 0.410072120665541 no 2014 0.416304309614335 645 73157 A novel microtubule depolymerizer. SGTC_279 1273-0055 2.93 µM -0.21260356494715 0.409616063358782 no 2015 0.415818095294774 643 2847562 SGTC_1268 0828-0275 2.46 µM -0.212977495252668 0.409479271856018 no 2016 0.415672258086536 655 745337 SGTC_1695 st026914 34.495 µM -0.213702275020025 0.409214163698011 no 2017 0.415389618558798 644 3289191 SGTC_1851 st056236 18.9 µM -0.213859462488461 0.409156673527316 no 2018 0.415328326548583 635 5393171 SGTC_361 000s-0510 1.45 µM -0.214953901896318 0.40875644452196 no 2019 0.414901629675786 650 660 SGTC_183 3914-0051 30.55 µM -0.215424746936275 0.408584288953473 no 2020 0.414718088823132 622 1596232 SGTC_2400 5203494 178.7 µM -0.215799384483032 0.408447322431169 no 2021 0.414572064063133 618 6777674 SGTC_844 0330-0132 15.3 µM -0.21602247062795 0.408365768022243 no 2022 0.414485116023255 649 2828079 SGTC_278 4092-0821 23.9 µM -0.217603954947024 0.407787733069145 no 2023 0.413868851365588 665 877900 SGTC_780 0109-0199 192 µM -0.21764144851915 0.407774031541042 no 2024 0.413854243630998 640 610414 SGTC_1398 3558-0053 112 µM -0.21887565566074 0.407323069995098 no 2025 0.413373455325051 648 4532369 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.220517994853057 0.406723173395004 no 2026 0.412733879710804 642 279621 SGTC_2235 salicylic acid 500 µM -0.221031296980894 0.406535724541876 no 2027 0.412534032056226 635 338 A COX inhibitor and kinase inhibitor. SGTC_2379 9035213 200 µM -0.221068005267004 0.406522320145422 no 2028 0.412519741020024 626 646551 SGTC_1561 5-methoxyflavone 52.9 µM -0.221269877586693 0.40644860641427 no 2029 0.412441151447019 622 94525 SGTC_2630 antimycin a 100 µM -0.224069232600892 0.405426764029562 no 2030 0.411351716320174 663 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1381 2324-0066 62.1 µM -0.224586836650562 0.405237894533287 no 2031 0.411150353070419 683 10885928 SGTC_1232 0279-0259 161 µM -0.224844453176114 0.405143900585779 no 2032 0.411050141360449 642 1560000 SGTC_51 1013-0126 23.419 µM -0.22490006374613 0.405123611234915 no 2033 0.411028509851665 660 1627850 SGTC_318 1488-0629 67.2 µM -0.225207450459202 0.405011466709791 no 2034 0.410908946846434 665 3662576 SGTC_1600 coumarin 106 71.1 µM -0.22666850131382 0.404478535327271 no 2035 0.410340760967317 691 100336 A hepatotoxic, DNA x-linker. SGTC_1256 0570-0116 285 µM -0.227095960999705 0.404322649036433 no 2036 0.410174562332536 668 410638 SGTC_1493 4348-0038 111 µM -0.228095079537664 0.403958349085921 no 2037 0.409786162620441 640 800424 SGTC_1132 3456-3614 2.5 µM -0.22820261426639 0.403919144586758 no 2038 0.409744364583659 674 3125502 SGTC_797 k781-0471 270 µM -0.229707371212436 0.403370648883081 no 2039 0.4091595833314 633 23738129 SGTC_723 4182-0001 115 µM -0.230682619957642 0.403015264489569 no 2040 0.408780688330955 654 744821 YLR208W SEC13 SGTC_2992 9074591 71.4286 µM -0.230738244251692 0.402994997194742 no 2041 0.408759080239173 647 17741321 SGTC_3243 9134147 49.47 µM -0.231055120120163 0.402879545122012 no 2042 0.408635990344554 662 24282180 SGTC_755 1995-0008 37.3 µM -0.231358791622281 0.402768911936802 no 2043 0.408518038119866 633 689533 SGTC_2931 9014674 55.67 µM -0.231492279182193 0.40272028239472 no 2044 0.408466191441711 654 2996810 SGTC_2954 9074818 52.69 µM -0.231638264435432 0.402667101663693 no 2045 0.408409492483333 685 16648742 SGTC_2145 5634607 200 µM -0.232051974731935 0.402516401597852 no 2046 0.408248822680921 671 308662 SGTC_860 0443-0016 25.1 µM -0.232145686778905 0.402482267616571 no 2047 0.408212430523957 651 5337942 SGTC_2196 6573537 42.6665 µM -0.23218472251509 0.402468049332187 no 2048 0.408197271611126 672 2903087 SGTC_2564 betulinic acid 100 µM -0.233219076954774 0.402091345572512 no 2049 0.407795646490057 693 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_731 3966-0296 387 µM -0.233955509911963 0.401823197868699 no 2050 0.407509759058774 654 660956 SGTC_857 0438-0306 1.35 µM -0.234029720649164 0.401796179044221 no 2051 0.407480952760868 637 4686136 SGTC_592 k241-0073 46.5 µM -0.234966846043152 0.401455028596174 no 2052 0.407117232954674 673 4230158 SGTC_1188 1403-0014 4.57 µM -0.235206018689215 0.401367972378883 no 2053 0.407024417393684 641 9614867 SGTC_2443 5493264 126.67 µM -0.235376373024924 0.401305968256178 no 2054 0.406958311289667 665 5340055 SGTC_2060 5238662 140 µM -0.237717064667893 0.40045427552443 no 2055 0.406050273664836 672 790130 SGTC_2331 7980721 200 µM -0.239421589072205 0.399834358417341 no 2056 0.405389345538089 650 2981221 SGTC_2732 terfenadine 20 µM -0.240657494329328 0.399385030769475 no 2057 0.404910292701052 651 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_306 1672-3436 11.6 µM -0.240700544798162 0.399369381671844 no 2058 0.404893608347073 678 6797378 SGTC_2044 5102272 200 µM -0.240758818017269 0.399348199272873 no 2059 0.404871024640432 642 592666 SGTC_781 4335-2806 94.4 µM -0.241351498145584 0.399132776036922 no 2060 0.404641350275925 685 845254 SGTC_2229 7354935 190 µM -0.241460335233481 0.399093220028115 no 2061 0.404599177486371 674 318112 SGTC_2278 7948257 134.34 µM -0.241817866739377 0.398963285226131 no 2062 0.404460647027534 632 1247028 SGTC_5 0352-0601 109.883 µM -0.242461692433273 0.39872933306862 no 2063 0.404211218193063 666 762456 SGTC_2800 7887935 81.82 µM -0.243851772445685 0.398224332620491 no 2064 0.403672810869804 688 2961002 SGTC_903 1134-0042 114 µM -0.244984637965935 0.397812901302092 no 2065 0.403234163054761 644 701009 SGTC_823 0417-1665 178 µM -0.246979787558339 0.397088584295592 no 2066 0.402461933391813 697 3429856 SGTC_2714 st079313 56.9 µM -0.248174162837666 0.39665514916882 no 2067 0.401999828094886 643 2939799 SGTC_2906 7926292 26.41 µM -0.248571491074995 0.396510988241767 no 2068 0.40184613162797 701 2966319 SGTC_2016 5121758 140 µM -0.249843625003462 0.396049520503374 no 2069 0.401354140724178 686 2795203 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.250604614090772 0.395773540594229 no 2070 0.401059907007269 652 803109 SGTC_2311 7694451 200 µM -0.250826579859703 0.395693052438903 no 2071 0.400974095296566 659 2163142 SGTC_21 0849-0113 22.993 µM -0.25213513091989 0.395218642485612 no 2072 0.400468308195038 650 1560156 SGTC_2106 5357045 167.29 µM -0.252404639246515 0.395120952578998 no 2073 0.400364157306089 656 668842 SGTC_2252 omeprazole 400 µM -0.253605841233891 0.394685627685546 no 2074 0.399900041744982 661 4594 A proton pump inhibitor. SGTC_2202 7226349 200 µM -0.253818355333561 0.394608624603249 no 2075 0.399817946106697 640 844334 SGTC_1417 3966-0327 90.4 µM -0.254260689827464 0.394448360825036 no 2076 0.399647083495709 655 651118 SGTC_2517 totarol 10 µM -0.255407903895224 0.394032792944048 no 2077 0.399204033381376 662 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1074 carmofur 3.8 µM -0.255839270649686 0.393876565432647 no 2078 0.399037474578574 664 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2708 st078559 56 µM -0.256465696815865 0.393649723932069 no 2079 0.39879563240933 651 17250902 SGTC_36 0335-0881 14.2 µM -0.25740828812555 0.393308460707102 no 2080 0.398431802703114 666 23828853 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.258758461832729 0.392819775958299 no 2081 0.397910804591702 651 688662 SGTC_1780 st038448 24.544 µM -0.260286407313366 0.392266951857868 no 2082 0.397321428374914 701 728868 YDL195W SEC31 SGTC_3086 9117350 49.47 µM -0.262262356365464 0.391552358559781 no 2083 0.396559590890007 642 2679265 SGTC_524 r073-0010 27.8 µM -0.262490915709807 0.391469724634433 no 2084 0.396471494055248 687 2772106 SGTC_3237 9133362 49.47 µM -0.263125477048359 0.391240329402295 no 2085 0.396226933895233 702 43845137 SGTC_1418 3966-3099 2.4 µM -0.264911568829335 0.390594856856338 no 2086 0.395538793003026 664 740335 SGTC_1144 3486-0183 12.5 µM -0.265171076770796 0.390501098774473 no 2087 0.395438837479945 702 6744069 SGTC_2104 5389443 200 µM -0.265665588509612 0.390322453386546 no 2088 0.395248383821691 680 2244536 SGTC_2389 9091542 195.52 µM -0.266716214926833 0.389942985073349 no 2089 0.394843834169271 655 3626624 YOL127W RPL25 SGTC_2375 9072683 200 µM -0.267849123216747 0.389533915464111 no 2090 0.394407728437582 693 16798029 SGTC_3138 9097216 49.47 µM -0.26896707573044 0.389130366017527 no 2091 0.393977509540122 668 25237486 SGTC_2943 9068529 45.32 µM -0.269590116667869 0.388905517600747 no 2092 0.393737802335602 653 3270634 SGTC_982 1491-0518 27.5 µM -0.26996489960476 0.388770280601092 no 2093 0.393593628677382 651 3091256 SGTC_1320 1313-0481 95.3 µM -0.270099048511514 0.388721877468108 no 2094 0.393542027047441 681 6813365 YLR208W SEC13 SGTC_1273 0849-0096 14.1 µM -0.270148386508242 0.388704075941505 no 2095 0.393523049196405 694 5286025 SGTC_3196 9111891 49.47 µM -0.270356587041843 0.388628958170878 no 2096 0.39344296768721 666 18891510 SGTC_135 0933-0004 26.348 µM -0.270782984486075 0.388475128984724 no 2097 0.393278973770436 659 21230617 YGL099W LSG1 SGTC_929 2805-0021 398 µM -0.270818546135391 0.388462300383471 no 2098 0.393265297493378 709 3098024 SGTC_116 0155-0182 31.788 µM -0.272101916788169 0.387999415465034 no 2099 0.392771827875265 675 771486 SGTC_2585 alliin 100 µM -0.272308313721245 0.38792498724626 no 2100 0.392692482129885 693 87310 A garlic compound which reacts with lipids. SGTC_3343 9148379 18.9835 µM -0.27453636613104 0.3871217981584 no 2101 0.39183623031303 671 1955036 SGTC_340 k038-0059 454 µM -0.275878656477082 0.386638149768858 no 2102 0.391320633826022 657 23733424 SGTC_1905 st060207 84.5 µM -0.276318348668524 0.386479759971994 no 2103 0.39115178206353 646 1948547 SGTC_2766 oltipraz 83.91 µM -0.277976053367242 0.385882777232073 no 2104 0.390515370613306 676 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2740 felodipine 17.08 µM -0.278352759385744 0.385747153181073 no 2105 0.390370789767979 661 3333 L-type calcium channel blocker SGTC_1656 st012921 11 µM -0.278622301263607 0.385650119603061 no 2106 0.390267348128804 668 6732821 SGTC_456 gingerol 170 µM -0.279402450532458 0.385369310550991 no 2107 0.389967995343404 705 442793 A herb. SGTC_1358 1509-0022 2.48 µM -0.279656149857697 0.385278006264875 no 2108 0.389870661869637 669 3258434 SGTC_2033 5192550 145 µM -0.281224997900627 0.384713532270914 no 2109 0.389268916240542 648 182073 SGTC_1558 st069300 45.6 µM -0.281251749277096 0.384703909198632 no 2110 0.389258657809746 683 24208000 SGTC_3108 9121785 49.47 µM -0.281330544855302 0.384675565068259 no 2111 0.389228442280883 639 17140271 SGTC_2703 st077852 53.4 µM -0.281359776245092 0.384665050189239 no 2112 0.389217233168627 694 6281836 SGTC_1284 0929-0043 16 µM -0.28181589021948 0.384500991555607 no 2113 0.389042342972373 680 1239883 SGTC_853 0419-0306 21 µM -0.283713945249614 0.383818506753113 no 2114 0.388314803466021 667 762713 SGTC_2141 5621638 7.665 µM -0.28440106233887 0.38357152833334 no 2115 0.388051522485395 704 2856238 SGTC_2103 5378138 10 µM -0.286964400656087 0.382650576168826 no 2116 0.387069789245205 680 244142 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.28807669538566 0.38225115867769 no 2117 0.38664401559351 665 16725076 SGTC_1409 3909-8004 61.9 µM -0.289816286761892 0.381626734502765 no 2118 0.385978393663122 652 2119279 SGTC_1334 1486-0610 236 µM -0.290302753340723 0.381452172950019 no 2119 0.385792316322463 649 3742339 SGTC_1263 0774-1208 64.8 µM -0.291228921375865 0.38111989751595 no 2120 0.385438122342303 698 906585 SGTC_2619 obliquin 87.91 µM -0.29166882562229 0.380962106538416 no 2121 0.385269923423756 667 6708593 A bioactive alkalod. YER133W GLC7 SGTC_664 1222-0054 14.9 µM -0.293274473356605 0.380386338612772 no 2122 0.38465618178082 668 6813991 SGTC_19 0279-0214 38.434 µM -0.293421295963155 0.380333702812748 no 2123 0.384600074809254 657 3566274 YBR002C RER2 SGTC_2402 5553605 200 µM -0.293601392653422 0.38026914130333 no 2124 0.384531255739323 689 6758546 SGTC_2061 5245884 80.95 µM -0.295017443267154 0.379761628309728 no 2125 0.383990277317943 684 573863 SGTC_146 3448-8650 53.125 µM -0.295429367474369 0.379614033376781 no 2126 0.383832950953812 705 2891488 YIL048W NEO1 SGTC_1454 4239-0054 42.6 µM -0.297463254244924 0.378885536933002 no 2127 0.383056428927239 712 1340767 SGTC_1042 0350-0096 82 µM -0.298517788016838 0.378507993725825 no 2128 0.382654000896558 663 3122515 SGTC_1168 k815-0004 80.5 µM -0.298564128056815 0.378491405764199 no 2129 0.382636319651146 658 642433 SGTC_2317 5986382 200 µM -0.298702508252194 0.378441872280522 no 2130 0.382583521537024 673 877883 SGTC_1435 4092-0789 56.7 µM -0.29941551761498 0.378186680746133 no 2131 0.38231151180293 681 2248285 SGTC_2989 9073649 71.4286 µM -0.299862157251958 0.378026852043284 no 2132 0.382141150442439 716 21367202 SGTC_2771 fluoxetine 41.05 µM -0.300024605154068 0.377968725706417 no 2133 0.382079193739724 692 3386 A selective serotonin reuptake inhibitor. SGTC_836 0330-0104 1.35 µM -0.301178383510946 0.377555965773121 no 2134 0.38163923623122 664 46494820 SGTC_2244 6635614 200 µM -0.301891168791278 0.377301039309053 no 2135 0.381367514074279 649 836499 SGTC_2461 5755302 26.15 µM -0.302245311312642 0.377174400699558 no 2136 0.381232532499493 728 2788904 SGTC_300 r073-0011 5.04 µM -0.302890096177407 0.376943864576197 no 2137 0.380986809579033 687 2735780 SGTC_1103 duloxetine 36.1 µM -0.30292767293021 0.376930430750833 no 2138 0.380972490824938 682 60835 A selective serotonin reuptake inhibitor. SGTC_1828 st055811 49 µM -0.303037260588066 0.376891253616713 no 2139 0.380930732992537 711 5877589 SGTC_1072 oxiconazole 14.9 nM -0.3033156265431 0.376791744639778 no 2140 0.380824669264757 673 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2582 agaric acid 100 µM -0.306613844972793 0.375613337417637 no 2141 0.37956865708713 679 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1901 st060216 58.6 µM -0.312733373659334 0.373429994025159 no 2142 0.377241618967874 660 688792 SGTC_2283 7944793 200 µM -0.313953124442817 0.372995290448687 no 2143 0.37677832060627 657 2970533 SGTC_967 1306-0166 352 µM -0.313993720869843 0.372980825177999 no 2144 0.376762903898058 664 4437607 SGTC_2195 6536160 144.242 µM -0.314280009879804 0.372878820103134 no 2145 0.376654189710758 669 3834386 SGTC_3161 9100388 49.47 µM -0.315251692043005 0.372532675225042 no 2146 0.3762852801876 672 25236368 SGTC_1781 st038725 66.3 µM -0.315613748641639 0.372403725162532 no 2147 0.376147850405536 666 4270275 YIL048W NEO1 SGTC_960 1222-0186 7.7 µM -0.316417391713923 0.372117550809459 no 2148 0.375842858952636 707 3126296 SGTC_368 fentichlor 4.58 µM -0.316844206660528 0.371965592273382 no 2149 0.37568090946734 723 7329 A pesticide. SGTC_1146 3579-1023 7 µM -0.317564757557224 0.371709100453964 no 2150 0.375407555330428 681 X1146 SGTC_1680 diphenhydramine 100 µM -0.319378596867944 0.371063687125943 no 2151 0.374719719436696 712 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3079 9117512 49.47 µM -0.321059558859703 0.370465878738875 no 2152 0.374082628275916 702 7185044 SGTC_348 k064-0012 10.7 µM -0.322104139907472 0.370094546910635 no 2153 0.373686901047851 679 5066323 SGTC_1465 k213-0056 144 µM -0.323439987186031 0.369619851033615 no 2154 0.373181025071716 684 24048857 YMR208W ERG12 SGTC_2006 4011487 200 µM -0.323987096483848 0.369425492000239 no 2155 0.372973901656846 680 45595294 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.324374176408753 0.369288003100514 no 2156 0.372827383975246 681 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1219 1469-0211 33.1 µM -0.324582835481649 0.36921389535011 no 2157 0.372748409870978 720 6822282 SGTC_1840 st055363 71 µM -0.325778319974287 0.368789398592366 no 2158 0.372296041410933 703 676033 SGTC_1850 st056238 17 µM -0.327677025633858 0.3681155287293 no 2159 0.371577938026792 691 5393177 SGTC_1957 st077035 62.4 µM -0.328007154372035 0.367998404031549 no 2160 0.371453126609205 701 705593 SGTC_2184 6075246 200 µM -0.328303049695045 0.367893435260764 no 2161 0.371341269266748 671 2267320 SGTC_885 0865-0106 16.8 µM -0.330348828741087 0.367167966068257 no 2162 0.370568200912624 681 2793380 SGTC_2262 9014885 67.46 µM -0.330526300409751 0.367105053802593 no 2163 0.370501161683551 686 6457424 SGTC_2851 9015922 71.43 µM -0.331836633810248 0.366640661782962 no 2164 0.370006310187771 703 2996893 SGTC_2030 5175110 200 µM -0.332050776812796 0.366564786425918 no 2165 0.369925458846023 732 2831986 SGTC_38 0929-0051 58.268 µM -0.332819843544263 0.366292332964819 no 2166 0.369635139192397 706 1379719 SGTC_1101 ebselen 5.29 µM -0.334949946927768 0.365538063956385 no 2167 0.36883142193971 711 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_23 0213-0011 39.996 µM -0.337472606807407 0.364645463070365 no 2168 0.367880329413028 714 627608 SGTC_2762 leflunomide 42.06 µM -0.338175646194821 0.36439683482452 no 2169 0.367615413677525 690 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3216 9129716 49.47 µM -0.339643862485178 0.363877787607402 no 2170 0.367062371089325 678 8056934 SGTC_3179 9107801 49.47 µM -0.340004508667442 0.363750329294609 no 2171 0.366926566284431 680 4818259 SGTC_296 1222-0039 74.9 µM -0.340604142773955 0.363538442083 no 2172 0.366700805134155 693 5984176 SGTC_3192 9110362 49.47 µM -0.342135070426613 0.362997661643622 no 2173 0.366124622942323 673 16649480 SGTC_2186 6124449 200 µM -0.342273909386514 0.362948632061237 no 2174 0.366072384210471 690 3834182 YLR033W RSC58 SGTC_1797 st048695 56.8 µM -0.344426736416272 0.362188670763596 no 2175 0.365262692371718 737 592262 YIL048W NEO1 SGTC_1182 1222-0449 220 µM -0.34466514741992 0.362104543536332 no 2176 0.365173061339474 687 658318 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.345274336685561 0.361889611390751 no 2177 0.364944069036355 715 4213774 SGTC_517 1365-0151 113 µM -0.345370566154248 0.361855664008875 no 2178 0.364907901088553 710 768657 SGTC_3145 9085516 49.47 µM -0.345388741835021 0.361849252199259 no 2179 0.364901069874619 681 25236195 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.345754712454862 0.361720157506624 no 2180 0.364763531274052 741 65057 A dermal irritant. YDR527W RBA50 SGTC_2581 avocatin a 64 µM -0.346320615559021 0.361520568401944 no 2181 0.364550888574121 742 6710728 A skin care supplement. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.348074422628883 0.360902255418714 no 2182 0.36389214623659 683 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3257 9139206 32.98 µM -0.348295361748485 0.360824388023861 no 2183 0.363809188416073 714 4910041 SGTC_2474 5321570 43.32 µM -0.348872047289128 0.360621169173559 no 2184 0.363592685658846 714 2841384 SGTC_2173 5763948 167 µM -0.34939883367313 0.360435568734997 no 2185 0.363394954405643 689 2867177 SGTC_1727 st034309 9.9045 µM -0.349494620969397 0.360401823930039 no 2186 0.363359004191955 722 870305 SGTC_509 pifithrin 175 µM -0.351856022003324 0.359570272875496 no 2187 0.36247312104571 712 4817 A p53 inhibitor. SGTC_2356 9061756 188.97 µM -0.351896530076208 0.359556014023774 no 2188 0.362457930787811 673 20104043 SGTC_2450 5739737 12.93 µM -0.354425644572743 0.358666153027736 no 2189 0.361509959347255 693 2262825 SGTC_1686 st019653 115.5 µM -0.355849052669416 0.35816566820664 no 2190 0.360976805797809 731 97252 SGTC_283 0987-0079 11.7 µM -0.355947333021586 0.358131120812767 no 2191 0.360940003737304 688 411556 SGTC_1136 pergolide 1.05886 µM -0.358910050036754 0.357090216480449 no 2192 0.359831190518767 703 47811 A dopamine receptor agonist. SGTC_256 clotrimazole 625 nM -0.359553546006314 0.356864274445741 no 2193 0.359590514075326 684 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_155 k072-0202 43.6 µM -0.360338828837458 0.356588616725587 no 2194 0.359296882815211 683 5857737 SGTC_3314 9135860 59.4275 µM -0.360409903323358 0.356563671152784 no 2195 0.359270310894415 684 25252478 SGTC_2889 9059656 51.95 µM -0.361299447672578 0.356251512684006 no 2196 0.358937803282051 704 3949838 SGTC_1084 voriconazole 435 nM -0.361812868648001 0.356071387064813 no 2197 0.358745937485179 720 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_60 0986-0278 202 µM -0.363468137460107 0.355490881081439 no 2198 0.358127605195035 761 3110598 SGTC_2843 9000894 45.46 µM -0.364547199946247 0.355112632095676 no 2199 0.357724717235194 674 2242070 SGTC_1508 1080-0625 72.9 µM -0.364923671870659 0.354980699138727 no 2200 0.357584191735179 689 767111 SGTC_813 k007-0158 173 µM -0.365032800793559 0.354942458629633 no 2201 0.357543460841129 697 6523916 SGTC_590 k048-0076 22.4 µM -0.365614502241617 0.354738645859167 no 2202 0.357326376030481 721 6832814 SGTC_917 harmaline 728.087 nM -0.366146540260788 0.354552270236031 no 2203 0.35712786550376 697 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3019 9081971 49.47 µM -0.3668876524657 0.354292712898923 no 2204 0.356851411047156 713 16451803 SGTC_1184 1269-1718 139 µM -0.367551239447484 0.354060364385649 no 2205 0.35660393932273 680 5403821 SGTC_2583 asiatic acid 100 µM -0.369619774608961 0.353336435937197 no 2206 0.355832907490977 726 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.370554477860321 0.353009490190664 no 2207 0.355484696603209 699 442882 SGTC_2513 baicalein 25.65 µM -0.370881163113003 0.352895245963774 no 2208 0.355363022913232 724 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2814 7977482 42.97 µM -0.371844522124729 0.352558429506316 no 2209 0.355004306406792 718 6456762 SGTC_521 r062-0005 13.8 µM -0.372470827278565 0.352339518195728 no 2210 0.354771164221719 704 2832033 SGTC_2810 7959871 45.46 µM -0.372515001484487 0.352324079910866 no 2211 0.354754722419241 705 2974535 SGTC_1682 st012968 530 nM -0.372921516474826 0.352182019869872 no 2212 0.354603428744251 693 24207270 SGTC_980 1473-0395 201 µM -0.373341030687656 0.352035438766542 no 2213 0.354447321163065 708 768876 SGTC_1892 st058411 7.36 µM -0.374245757302392 0.351719396021274 no 2214 0.354110741957604 716 3934738 SGTC_156 3474-0145 5.642 µM -0.374850691894188 0.351508134968255 no 2215 0.353885755861126 715 2265471 SGTC_464 bw-b 70c 158 µM -0.376803855758906 0.350826345723755 no 2216 0.35315968755797 746 5353454 SGTC_946 3434-1334 87.4 µM -0.378237464660552 0.350326222442596 no 2217 0.352627098184811 698 4047976 SGTC_2563 tomatine 8.54 µM -0.378385003857963 0.350274767193852 no 2218 0.352572303365209 779 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2770 toltrazuril 17.5 µM -0.378791520631238 0.350133006061364 no 2219 0.352421342276106 698 68591 Kills coccidiodes. SGTC_320 4092-0846 5.34 µM -0.379272761559636 0.349965214002307 no 2220 0.352242662219751 691 1359356 SGTC_1675 st018485 24.5 µM -0.379868325993186 0.349757601851902 no 2221 0.352021580116822 711 3323024 SGTC_2865 9030313 51.95 µM -0.381364559100061 0.349236217333736 no 2222 0.351466377614992 704 42562754 SGTC_220 paclitaxel 373.376 µM -0.386675847557852 0.347387722920374 no 2223 0.349498099396776 719 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2927 9011802 47.9 µM -0.387183149126363 0.347211355027972 no 2224 0.349310312108714 722 43912568 SGTC_201 4262-0159 12.803 µM -0.387393917431898 0.347138089281801 no 2225 0.349232303069033 725 1341029 SGTC_1138 3761-0006 1.03 µM -0.387843827578953 0.346981713903669 no 2226 0.349065804759888 720 12061087 SGTC_2214 7179297 48.276 µM -0.388084696018727 0.346898005909264 no 2227 0.348976678481543 687 769744 SGTC_451 chloral hydrate 100 µM -0.389255445221444 0.346491246853227 no 2228 0.348543595924184 738 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3105 9121040 49.47 µM -0.390482276183011 0.346065192898589 no 2229 0.348089979382671 688 41448907 SGTC_405 ebelactone b 50 µM -0.390658655631093 0.346003955832333 no 2230 0.348024781535431 712 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1959 st077091 55.8 µM -0.391156006421393 0.345831302626859 no 2231 0.347840962314454 727 821356 YKL052C ASK1 SGTC_660 4031-1742 102 µM -0.393929575631901 0.344869058583631 no 2232 0.346816517021313 695 6738706 SGTC_2532 xanthone 78.9 µM -0.394050623716712 0.344827085736684 no 2233 0.346771832139553 736 7020 An insecticide. SGTC_2912 7964298 10.93 µM -0.395746944710341 0.344239095612207 no 2234 0.346145859975173 719 2975850 SGTC_1626 st003712 1.76 µM -0.396594071771801 0.343945599564703 no 2235 0.345833412429038 749 24207035 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.397387874211667 0.343670663697226 no 2236 0.345540727956754 721 616764 SGTC_649 1123-0311 367 µM -0.397908575396639 0.343490362161718 no 2237 0.345348789316712 742 693629 YIL048W NEO1 SGTC_2451 5856223 45.7 µM -0.398555411532666 0.343266433871913 no 2238 0.345110410735584 703 2179896 SGTC_284 0988-0104 32.6 µM -0.400541589341776 0.342579182827036 no 2239 0.344378828819109 719 4666532 SGTC_816 0325-0417 81.3 µM -0.401010340156584 0.342417063007738 no 2240 0.344206255516704 707 68101 SGTC_3020 9089140 49.47 µM -0.402160394609474 0.342019433947478 no 2241 0.343782993849027 702 17217859 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.405327628510172 0.340925275540777 no 2242 0.342618350241473 730 94937 An inhibitor of serotonin biosynthesis. SGTC_69 0096-0274 206.684 µM -0.407798539179921 0.340072597787836 no 2243 0.341710793092929 743 6741392 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.408039834983137 0.339989373615873 no 2244 0.34162221487206 736 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1429 4049-0205 9.46 µM -0.409746942014969 0.339400806467716 no 2245 0.340995795615 718 22774478 SGTC_2625 euphol 100 µM -0.410939176970126 0.338989986249801 no 2246 0.340558567245817 729 6708538 A triterpene alcohol. SGTC_2119 5528445 120.635 µM -0.412585375910939 0.338423053819379 no 2247 0.339955208759953 722 791935 SGTC_2120 5538279 151.968 µM -0.413380185418632 0.338149461296522 no 2248 0.339664044804481 726 2058197 SGTC_843 0310-0051 143 µM -0.414293880144624 0.33783505120699 no 2249 0.339329447607611 755 2065037 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.414607404619679 0.33772719083708 no 2250 0.339214663364046 770 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1615 st002656 86.5 µM -0.414985064666055 0.337597283898779 no 2251 0.339076418298641 696 1584458 SGTC_2897 9048598 12.99 µM -0.415192350090571 0.337525990391993 no 2252 0.339000549246679 713 6467404 SGTC_4 0960-0234 25.671 µM -0.415501239833839 0.337419762034438 no 2253 0.338887503861279 704 6821112 SGTC_3311 9131146 2.8755 µM -0.415706891933735 0.337349044679182 no 2254 0.338812248736763 721 4900406 YPR165W RHO1 SGTC_970 1315-0089 19.5 µM -0.416208507087382 0.337176578944472 no 2255 0.338628717615052 713 6811083 YLR033W RSC58 SGTC_3225 9130819 49.47 µM -0.417519182913565 0.336726102870474 no 2256 0.33814934803967 764 4547121 SGTC_3151 9099821 49.47 µM -0.417770324423224 0.336639812861464 no 2257 0.338057524888405 765 17174189 SGTC_2833 9001315 45.46 µM -0.418004085546004 0.336559502328463 no 2258 0.337972065065496 703 2989378 SGTC_1701 st028638 40.4 µM -0.41914709242995 0.336166920425122 no 2259 0.337554317914939 729 3490878 SGTC_78 0336-0123 156.75 µM -0.420869774373646 0.335575578465952 no 2260 0.33692508879696 700 6765896 SGTC_954 1189-0853 2.85 µM -0.421219708273295 0.335455506969413 no 2261 0.336797327148834 742 2828194 SGTC_1374 2889-5571 141 µM -0.421443970340521 0.335378565608221 no 2262 0.336715458467482 718 2853281 SGTC_1980 st071811 45.7 µM -0.421591374356064 0.335327996992381 no 2263 0.336661651653458 755 4974850 SGTC_2226 7298446 200 µM -0.42215095259251 0.335136054513588 no 2264 0.336457419538069 746 3283010 SGTC_777 1315-0167 517 µM -0.423487426609464 0.334677801101883 no 2265 0.335969835107473 709 4221767 SGTC_1009 4106-0057 9.87 µM -0.424662107706164 0.334275226836016 no 2266 0.335541505205254 751 2928005 SGTC_2888 9058547 12.99 µM -0.426199655824736 0.333748582594586 no 2267 0.33498118413209 715 16476514 SGTC_1271 0832-2808 169 µM -0.426942693746687 0.333494192928065 no 2268 0.334710533976863 735 3663794 SGTC_1122 capsaicin 818.572 nM -0.427231543264381 0.333395321818147 no 2269 0.334605344253061 753 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2129 girgensonine 121.053 µM -0.427395150895427 0.333339325237962 no 2270 0.334545769362547 741 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1731 st035964 63 µM -0.430666791280186 0.33222035011128 no 2271 0.333355334320737 757 6739575 SGTC_658 3253-0951 102 µM -0.430959814677149 0.332120202231295 no 2272 0.33324879502706 732 1184878 SGTC_1050 3232-1156 69.3 µM -0.431004040051546 0.332105088174019 no 2273 0.333232716454935 750 700529 SGTC_163 TUB2.036 7.546 µM -0.431366480958476 0.331981233995622 no 2274 0.333100959029807 733 15992207 YJR013W GPI14 SGTC_3303 9125618 40.5795 µM -0.434438057262116 0.330932345659817 no 2275 0.331985183345715 742 22695467 SGTC_3309 9129340 25.759 µM -0.434733974881796 0.33083136497261 no 2276 0.331877767247099 711 17158987 SGTC_371 0195-0006 7.36 µM -0.437165908805194 0.330001944189858 no 2277 0.330995515745675 710 3928593 SGTC_791 1348-1292 225 µM -0.437316443319291 0.329950631192475 no 2278 0.330940935941335 762 5437054 SGTC_3334 9142812 21.919 µM -0.43766094434595 0.329833212486955 no 2279 0.330816042568648 716 45283678 SGTC_3026 9090633 49.47 µM -0.438867317567095 0.329422168045524 no 2280 0.330378839623248 735 25236842 SGTC_1703 st026983 48.3 µM -0.43908722112365 0.329347263060793 no 2281 0.330299169072629 742 1104023 SGTC_589 1227-0070 34.1 µM -0.439960031380921 0.329050028292247 no 2282 0.329983027819032 712 2841384 SGTC_3069 9117009 49.47 µM -0.440030021738403 0.329026197814639 no 2283 0.329957681813695 731 41904981 SGTC_892 0929-0076 29 µM -0.441344825641625 0.328578659587311 no 2284 0.329481689590381 699 5751038 SGTC_487 nimodipine 119 µM -0.442760586636269 0.328097031989676 no 2285 0.328969457116258 729 4497 L-type voltage-gated calcium channels inhibitor SGTC_2074 5212007 75.395 µM -0.443451010154751 0.327862260451002 no 2286 0.328719773325393 724 758611 SGTC_2606 farnesol 9.78 µM -0.444156978140237 0.327622273498987 no 2287 0.328464547090463 745 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3262 9137218 49.47 µM -0.444641905922507 0.32745746825598 no 2288 0.328289279130222 729 17650664 SGTC_1983 st071813 46.9 µM -0.44699961330315 0.326656668647975 no 2289 0.327437669549394 731 11838595 SGTC_61 0978-8327 98.565 µM -0.448201103985659 0.326248886839845 no 2290 0.327004033026462 765 6150059 YHR072W ERG7 SGTC_2689 tacrolimus 100 µM -0.452487335198035 0.324795849000111 no 2291 0.325458971488352 752 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_945 3381-0768 11.3 µM -0.453583152990438 0.324424791743097 no 2292 0.325064440705725 752 1126236 YIL048W NEO1 SGTC_2010 4012422 159 µM -0.454779778839914 0.324019798682186 no 2293 0.324633839622473 733 952393 SGTC_1622 st003707 19.4 µM -0.455964998011356 0.323618871376101 no 2294 0.324207574116493 745 10140899 SGTC_57 miconazole 162.5 nM -0.45637520530095 0.323480157089178 no 2295 0.3240600961925 748 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2495 cafestol 54.53 µM -0.459044503241843 0.322578116305481 no 2296 0.323101104080041 760 16667697 An anti-infammatory. SGTC_1108 betulinic acid 729.144 nM -0.45917280029097 0.322534786883096 no 2297 0.323055040649992 712 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2841 9004761 38.96 µM -0.460850119852154 0.321968532108663 no 2298 0.322453070173572 717 2991039 SGTC_600 1495-0418 41.6 µM -0.461069699990518 0.321894433494814 no 2299 0.322374299819645 744 5377768 SGTC_809 3998-0021 90 µM -0.461387705729709 0.321787133135891 no 2300 0.322260235221797 766 715485 SGTC_3156 9099931 49.47 µM -0.461703478431755 0.321680600944552 no 2301 0.322146988144762 717 18111053 SGTC_2320 7373003 200 µM -0.46300305782012 0.321242316431549 no 2302 0.321681087649018 749 5415828 SGTC_3201 9113999 49.47 µM -0.463192706274708 0.321178378083455 no 2303 0.321613121908604 765 16649224 SGTC_2333 9017922 200 µM -0.463566331155143 0.321052429171788 no 2304 0.321479240623712 734 3163164 SGTC_217 ketoconazole 989 nM -0.463607406717827 0.321038583859191 no 2305 0.321464523400765 735 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_572 0960-0087 17.7 µM -0.463752294965408 0.320989748460719 no 2306 0.321412612712789 746 6796365 SGTC_37 0566-0070 1.56 µM -0.464932746910766 0.320591985941386 no 2307 0.320989809403286 751 1626686 SGTC_989 1501-0895 10.3 µM -0.465190210664794 0.32050525885601 no 2308 0.320897624228436 765 2830112 SGTC_695 3505-6186 243 µM -0.465741122284036 0.320319716302971 no 2309 0.320700406821411 773 1819379 SGTC_2504 purpurogallin 52.29 µM -0.466866490208912 0.319940841143771 no 2310 0.320297700682892 714 5281571 An antioxidant. SGTC_1148 3909-7663 27.7 µM -0.471135716048084 0.318505239921106 no 2311 0.318771910596177 774 4084526 SGTC_2499 avocadenofuran 51.48 µM -0.472410463506295 0.318077110443543 no 2312 0.31831691858724 751 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1717 st033143 58.0435 µM -0.472658068404542 0.317993979425789 no 2313 0.318228573422211 767 674616 SGTC_1502 4534-4282 27.7 µM -0.473228373457974 0.317802539753583 no 2314 0.318025128521449 764 3278949 SGTC_2212 7123476 200 µM -0.47351050836275 0.317707850870387 no 2315 0.317924502841527 742 1085715 SGTC_1171 0368-0077 21.4 µM -0.476571956262454 0.3166811487296 no 2316 0.316833478462592 739 3239779 SGTC_987 1497-1013 404 µM -0.477194698035756 0.316472475402055 no 2317 0.316611743114672 767 1676435 SGTC_710 3448-4187 58 µM -0.478036291217273 0.316190560399475 no 2318 0.316312187556389 732 3946412 SGTC_2671 danthron 100 µM -0.478464794029683 0.316047062514319 no 2319 0.316159713116985 749 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2929 9013348 24.6 µM -0.478538992686026 0.31602221753265 no 2320 0.316133314134239 739 2995952 SGTC_793 0488-0545 106 µM -0.481049482130167 0.315182085231599 no 2321 0.315240665514685 742 292548 SGTC_1756 st041558 35.5 µM -0.481292782312596 0.315100715808371 no 2322 0.315154213057471 781 3955792 SGTC_403 arphamenine a 50 µM -0.481858612452492 0.31491151401783 no 2323 0.314953194383843 770 5487158 An arginine aminopeptidase inhibitor. SGTC_2225 6654152 15.4 µM -0.482077179649058 0.314838442708491 no 2324 0.314875560153555 762 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2147 5545932 89.7195 µM -0.482116077585265 0.314825439123655 no 2325 0.314861744613045 778 797404 SGTC_1198 1612-1005 86.7 µM -0.482669447739152 0.314640472285351 no 2326 0.314665229920073 746 6998509 SGTC_1143 3454-2408 5.08 µM -0.482931406709649 0.314552927358845 no 2327 0.314572220458188 755 X1143 SGTC_944 3370-0224 231 µM -0.482970873021881 0.31453973888622 no 2328 0.314558208823717 739 4580514 SGTC_266 formosanin C 406 nM -0.483205357431928 0.314461386021706 no 2329 0.314474965868313 754 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_635 k038-0028 24.7 µM -0.484739258504295 0.313949039904772 no 2330 0.313930657312553 774 4035102 SGTC_734 2023-0417 80 µM -0.484751783465565 0.313944857852754 no 2331 0.313926214463224 766 3935732 SGTC_1296 1068-0102 11.9 µM -0.485208511368122 0.313792373920961 no 2332 0.313764222552075 751 767053 SGTC_2760 etidronate 98.04 µM -0.48525391584565 0.313777216844489 no 2333 0.31374812048706 759 3305 A chelator and antioxidant. SGTC_89 0302-0250 142.109 µM -0.486923405663556 0.313220120504799 no 2334 0.313156305747768 764 4203518 YLR208W SEC13 SGTC_587 k089-0003 57 µM -0.48800342594027 0.312859952612999 no 2335 0.312773707210621 755 9659696 SGTC_874 0599-0792 117 µM -0.489285489229956 0.312432638702606 no 2336 0.312319796404755 784 765305 SGTC_3322 9139058 2.11 µM -0.489857470435337 0.312242077666312 no 2337 0.312117379901358 740 4908926 YPR165W RHO1 SGTC_1024 4507-0395 26 µM -0.490875065960059 0.311903180098822 no 2338 0.311757406663202 723 4201836 SGTC_741 4582-0002 126 µM -0.49254008530212 0.311349009457937 no 2339 0.311168795837191 735 2912688 SGTC_3341 9147222 25.867 µM -0.494266184995069 0.310774960340931 no 2340 0.310559101542384 771 1939759 SGTC_245 methotrexate 289.6 µM -0.494570183354433 0.310673907214814 no 2341 0.310451776812422 733 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1251 0490-5699 265 µM -0.494849007847976 0.31058123477545 no 2342 0.310353353745075 774 3883818 SGTC_401 neomycin 50 µM -0.495688712761308 0.310302216054529 no 2343 0.310057025919861 736 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_705 1124-0212 310 µM -0.49655889524255 0.31001318534786 no 2344 0.309750072819989 788 9554485 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.497391611022692 0.309736709070894 no 2345 0.309456460097784 757 5357218 A potent inhibitor of glutathione S-transferases. SGTC_124 0136-0217 7.121 µM -0.498143517737791 0.309487155259868 no 2346 0.309191444829052 781 3976905 SGTC_601 0986-0029 62.9 µM -0.50381681437225 0.307607056198927 no 2347 0.307195055397804 772 24747981 SGTC_656 4090-1979 187 µM -0.504858569519553 0.307262370811069 no 2348 0.306829087583445 765 22330961 SGTC_131 0141-0277 33.849 µM -0.505114430411676 0.307177740173222 no 2349 0.306739233263748 783 1547771 SGTC_2098 5376439 882.5 nM -0.508046162331432 0.306208750465619 no 2350 0.305710485036778 740 2844116 SGTC_2846 9008642 19.48 µM -0.508106498049489 0.306188822632596 no 2351 0.305689329218667 815 2992898 SGTC_440 fluspirilene 35.1 µM -0.510614669095093 0.305360925537045 no 2352 0.304810451063903 770 3396 An atypical antipsychotic. SGTC_879 0831-1030 162 µM -0.511245007093505 0.305153019786816 no 2353 0.304589753563867 771 1549252 SGTC_830 4076-0286 57.8 µM -0.512747018303112 0.304657861611374 no 2354 0.304064147641808 756 6866659 SGTC_2516 gossypol 71.55 µM -0.513313234416973 0.304471293643408 no 2355 0.303866113918959 774 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_17 0960-0276 49.807 µM -0.513539735512527 0.304396675869403 no 2356 0.303786911418538 773 6821114 SGTC_1830 st055982 50.3 µM -0.513581736889998 0.304382839968877 no 2357 0.303772225463955 799 455313 An antimicrobial agent. SGTC_831 k061-1017 217 µM -0.513832066007581 0.304300383510105 no 2358 0.303684703428364 759 1240153 SGTC_351 caspofungin 25 nM -0.514646290693696 0.304032253071441 no 2359 0.303400105662571 759 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2427 5545055 42.75 µM -0.514770106045374 0.303991488952454 no 2360 0.303356838647934 752 5372858 SGTC_2174 5790901 200 µM -0.514785638583349 0.303986375297976 no 2361 0.303351411029815 778 786020 SGTC_802 4112-3352 742 µM -0.517777870646415 0.303001982716494 no 2362 0.302306629933369 739 704594 SGTC_1560 lithocholic acid 53.1 µM -0.519242807918427 0.302520564408059 no 2363 0.301795715248918 757 9903 A bile acid which acts as a detergent. SGTC_3258 9138477 49.47 µM -0.520709562665796 0.302038892655243 no 2364 0.301284555905005 755 4970355 SGTC_2357 9067248 200 µM -0.521111355875733 0.301907006762423 no 2365 0.301144600314483 779 9150235 SGTC_1152 3909-8331 15.9 µM -0.521123662868605 0.30190296748402 no 2366 0.301140313913863 757 16001939 SGTC_1521 st012942 49.4 µM -0.521275746553795 0.301853054098522 no 2367 0.301087346979982 759 24207259 SGTC_50 0929-0078 56.389 µM -0.522428534609232 0.301474833352459 no 2368 0.300685996411312 749 1377751 SGTC_2545 solidagenone 89.61 µM -0.522587410076468 0.301422724279974 no 2369 0.300630701833911 717 6708572 An anti ulcer agent SGTC_1456 k015-0012 13 µM -0.523185696039133 0.301226530709068 no 2370 0.300422517247598 774 2989616 SGTC_1213 1315-0166 115 µM -0.523579099215057 0.301097554902514 no 2371 0.300285660892343 737 768401 SGTC_2569 tetrandrine 100 µM -0.523700682503829 0.301057699296324 no 2372 0.30024337042802 743 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.526306647072304 0.300204023484546 no 2373 0.299337582685094 765 2724278 An inhibitor of dopamine biosynthesis. SGTC_918 glabranin 770.725 nM -0.526890923685063 0.300012773330251 no 2374 0.29913466856439 765 124049 Also referred to as licorice root. SGTC_1147 3809-1045 12.3 µM -0.529231192667099 0.299247290743818 no 2375 0.298322540361542 751 325925 SGTC_2484 5809818 12.04 µM -0.530242844150673 0.298916662486592 no 2376 0.297971784584813 764 2870548 SGTC_773 4358-1457 44.6 µM -0.534363380800925 0.29757170514485 no 2377 0.296545074622591 804 1186886 SGTC_486 niguldipine 82 µM -0.538546217459584 0.29620924523557 no 2378 0.295100003247778 767 1236 A calcium channel blocker. SGTC_3147 9097027 49.47 µM -0.541340214852625 0.295300763928352 no 2379 0.294136553332169 771 25236841 SGTC_2426 5582046 32.21 µM -0.542757302249824 0.294840481983264 no 2380 0.293648457436142 777 2251934 SGTC_670 4204-0025 119 µM -0.544396735438066 0.294308393246876 no 2381 0.293084245900518 766 719039 SGTC_427 1354-0053 47.3 µM -0.545092379005647 0.294082751675556 no 2382 0.292844991948175 787 6813657 SGTC_2438 5259590 200 µM -0.545193081306945 0.29405009412362 no 2383 0.292810364737078 778 1201127 SGTC_2818 7996756 12.99 µM -0.546113455136248 0.293751696465572 no 2384 0.292493975688991 786 2241621 SGTC_712 r015-0009 80.6 µM -0.549041091791663 0.292803450037876 no 2385 0.291488625148861 759 6813872 YLR060W FRS1 SGTC_1855 st056195 39.6 µM -0.549250931997261 0.292735538492831 no 2386 0.291416627957479 773 4028379 SGTC_1940 st075990 51.1 µM -0.550795538668208 0.292235875608709 no 2387 0.29088692139752 788 1084979 SGTC_581 0958-0271 211 µM -0.551329905588404 0.2920631063405 no 2388 0.290703770733251 774 4591145 SGTC_2390 9097792 176.6 µM -0.553315493693366 0.291421551268615 no 2389 0.290023696747963 761 4497149 SGTC_901 1112-0062 60.1 µM -0.554713428575083 0.290970265123262 no 2390 0.289545344806445 773 1908457 SGTC_484 loperamide 105 µM -0.555806956581365 0.290617476437133 no 2391 0.289171414683473 766 3955 An opioid-receptor agonist. SGTC_529 4076-0302 30.3 µM -0.556277075611605 0.290465870453911 no 2392 0.289010728062102 780 5816522 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.55671929716274 0.29032329476646 no 2393 0.288859615145587 791 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2502 avocadyne acetate 18.59 µM -0.557145183751942 0.29018601658648 no 2394 0.288714119262737 749 3952079 SGTC_2419 paclitaxel 166.5 µM -0.560269620087396 0.289179832416859 no 2395 0.287647772996305 787 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_931 2812-0076 566 µM -0.562369487987361 0.28850452018736 no 2396 0.28693215160999 796 3450959 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.564556803915693 0.287801876125884 no 2397 0.286187626603427 770 5377381 SGTC_2638 epoxomicin 18 µM -0.568933541422602 0.286398343766123 no 2398 0.284700620956445 772 9915668 A protesome inhibitor. SGTC_2553 4-methylesculetin 85.09 µM -0.569422615477676 0.286241709488862 no 2399 0.284534686389198 783 5319502 SGTC_897 1000-0139 31.4 µM -0.570530342044535 0.285887091723406 no 2400 0.284159024354557 782 6151020 SGTC_2998 9066762 71.4286 µM -0.570941524903124 0.285755512464632 no 2401 0.284019640769641 792 4945196 SGTC_2910 7948405 25.97 µM -0.571166609622369 0.285683497149192 no 2402 0.283943354959013 783 2971328 SGTC_41 0478-0632 82.643 µM -0.571903147971928 0.285447903849673 no 2403 0.283693795625326 815 3750424 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.572504650080753 0.285255572650301 no 2404 0.283490068220996 773 4330530 SGTC_1607 st000305 50.6 µM -0.573259664519719 0.285014243080933 no 2405 0.283234445824654 805 5457690 SGTC_1457 k015-0032 57.3 µM -0.574002842401101 0.284776792017218 no 2406 0.282982938913321 805 4302660 SGTC_3130 9127414 49.47 µM -0.57505033908856 0.284442269143286 no 2407 0.282628626331189 799 1494646 SGTC_439 amiodarone 34.4 µM -0.575143387047816 0.28441256293176 no 2408 0.282597163455012 783 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1845 st056753 3.01 µM -0.577728733452103 0.283587766380427 no 2409 0.281723638412305 780 5375839 SGTC_1300 1094-0077 113 µM -0.578092571615733 0.283471784058177 no 2410 0.281600810994192 787 5532636 SGTC_1742 st038235 28.8875 µM -0.578186301418137 0.283441909072247 no 2411 0.281569173116524 809 564103 YBR002C RER2 SGTC_2097 5376186 200 µM -0.578817410977743 0.283240791552828 no 2412 0.281356190886962 765 742755 SGTC_248 streptozotocin 5.23457 mM -0.580525792132305 0.282696720455069 no 2413 0.280780049374956 817 5300 DNA alkylating agent. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.581428800745797 0.282409340765453 no 2414 0.280475745671597 761 4000243 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.58184533983709 0.282276825866422 no 2415 0.280335430525677 792 5106787 A p450 inhibitor. SGTC_3067 9117431 49.47 µM -0.583298499232916 0.281814762085592 no 2416 0.279846186327942 810 17150885 SGTC_838 0109-0203 71.4 µM -0.58392368873813 0.281616081630569 no 2417 0.279635827387113 765 759422 SGTC_621 3584-0052 32.1 µM -0.584018229927039 0.281586043042694 no 2418 0.279604023579246 805 2273927 SGTC_2932 9016711 44.54 µM -0.584613462368234 0.281396955239539 no 2419 0.279403826767827 804 7117328 SGTC_395 anisomycin 6.25 µM -0.584939195815522 0.281293505271993 no 2420 0.27929430107199 802 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2004 4023728 41.89 µM -0.585447163859387 0.281132215911036 no 2421 0.279123541855982 812 360084 YDR527W RBA50 SGTC_187 1488-2104 32.728 µM -0.588708721733767 0.280097675799526 no 2422 0.27802834307967 783 2852859 SGTC_1227 3909-8010 46.6 µM -0.589053241884366 0.279988504592492 no 2423 0.277912779177877 787 15982272 SGTC_1826 st055655 41.6 µM -0.589213106682107 0.27993785380048 no 2424 0.277859162993949 798 676168 SGTC_71 0417-1750 47.813 µM -0.589635629384191 0.279804005137984 no 2425 0.277717479720572 740 6811472 SGTC_2272 7805186 180 µM -0.59165458682781 0.279164859574019 no 2426 0.277040956295088 821 2956062 YPR165W RHO1 SGTC_1308 1187-1617 41.4 µM -0.592083956855652 0.279029024583831 no 2427 0.276897184695377 794 2882570 SGTC_377 3970-0964 33.1 µM -0.592202620704328 0.278991489900205 no 2428 0.276857457366965 792 16481235 SGTC_1277 0873-0036 22 µM -0.592456542804286 0.278911179791588 no 2429 0.276772456468617 795 5965735 SGTC_2391 6285546 200 µM -0.592720725019229 0.278827636568892 no 2430 0.276684034549425 796 846083 SGTC_637 1181-0519 7.26 µM -0.593376193772558 0.278620408105823 no 2431 0.276464708627557 793 6252091 YGR060W ERG25 SGTC_2988 9073640 71.4286 µM -0.59393774018574 0.278442933151511 no 2432 0.276276877821262 819 9102229 SGTC_1031 k035-0009 16 µM -0.597513973513395 0.277313970227855 no 2433 0.27508214022307 807 5180959 SGTC_1298 1079-1278 263 µM -0.597666711211959 0.277265803128401 no 2434 0.275031170773805 806 2840950 SGTC_1133 3473-0247 50 µM -0.598126574016562 0.277120806292185 no 2435 0.274877740003479 792 711311 SGTC_1950 st077106 7.18 µM -0.598145169627807 0.277114943791913 no 2436 0.274871536564549 764 13831864 SGTC_3102 9121669 49.47 µM -0.601041028585943 0.276202729199782 no 2437 0.2739063297917 805 41905072 SGTC_934 2950-0684 338 µM -0.602124650320333 0.275861760544878 no 2438 0.2735455835979 803 1121253 SGTC_1774 st048371 48.465 µM -0.604653884388508 0.275066726079502 no 2439 0.272704497702708 808 4242727 SGTC_3238 9133470 49.47 µM -0.605378297912441 0.274839223445204 no 2440 0.272463833740537 782 3534688 SGTC_3052 9092717 49.47 µM -0.605549771738636 0.274785385534151 no 2441 0.272406882313044 819 25237534 SGTC_2086 5274770 176.623 µM -0.606191183824574 0.274584046466199 no 2442 0.272193903206796 789 689278 SGTC_188 3229-0966 278.469 µM -0.607278388470596 0.274242939548153 no 2443 0.271833089051131 805 5722370 SGTC_1856 st057054 55.7 µM -0.60795860175428 0.274029631315983 no 2444 0.271607465538172 822 1266018 SGTC_268 camptothecin 39.6153 µM -0.610737262663744 0.273159122899241 no 2445 0.270686766489811 820 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2945 9067681 61.76 µM -0.611471943081779 0.272929188959885 no 2446 0.270443593608978 831 16456930 SGTC_1730 st033808 45.1 µM -0.612067464922206 0.27274287812754 no 2447 0.270246561158959 813 1045166 SGTC_820 1582-0060 59.9 µM -0.61224637282701 0.27268691857043 no 2448 0.270187382286477 800 3848840 SGTC_1222 0366-0074 1.18 µM -0.612589837437247 0.272579504255216 no 2449 0.270073789775983 801 286520 SGTC_1933 st074711 15.9 µM -0.612730690839399 0.272535460167112 no 2450 0.27002721287109 814 17250958 SGTC_2014 4013930 200 µM -0.614141404953962 0.272094532590968 no 2451 0.269560944747096 817 64556 SGTC_1490 4089-0339 670 nM -0.614951959137679 0.271841349311041 no 2452 0.269293223630575 802 742542 SGTC_993 3909-8757 62.7 µM -0.615213652373727 0.271759632310984 no 2453 0.269206816431147 802 4288324 YLR208W SEC13 SGTC_1467 k284-1082 293 µM -0.616112319824613 0.271479105222711 no 2454 0.268910195782329 812 3334705 SGTC_2148 5546263 113.568 µM -0.618001887959006 0.27088973052174 no 2455 0.26828704705275 791 792097 SGTC_224 benfluorex 43.875 µM -0.620573919140277 0.270088516400932 no 2456 0.267440002112181 819 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_610 4215-0184 155 µM -0.623644830183027 0.269133451392296 no 2457 0.266430431137483 795 5605015 SGTC_3013 9080133 71.4286 µM -0.624276663830821 0.268937159123012 no 2458 0.266222953389825 806 17050193 SGTC_7 0192-1582 4.227 µM -0.62482741381248 0.268766115834055 no 2459 0.266042168153547 834 252616 SGTC_3090 9117696 49.47 µM -0.626627923898347 0.268207323254587 no 2460 0.265451579881395 795 7923821 SGTC_2572 astragaloside iv 100 µM -0.627627786533528 0.267897266163301 no 2461 0.265123900815136 798 45006101 An anti-inflammatory agent. SGTC_998 3996-0085 177 µM -0.628359790692567 0.267670386419904 no 2462 0.264884135749747 813 715391 SGTC_3276 9139060 49.47 µM -0.628608111824637 0.26759344296659 no 2463 0.26480282418757 821 4870619 SGTC_742 0kpi-0133 140 µM -0.629194379088661 0.267411829586545 no 2464 0.26461090414556 807 2728852 SGTC_1413 3910-0535 34.4 µM -0.629236778358056 0.267398697587672 no 2465 0.264597027094465 801 2876951 SGTC_3227 9130768 49.47 µM -0.629734496916292 0.267244567381222 no 2466 0.264434154193212 814 17720899 SGTC_1865 st057639 52.2 µM -0.629806575705925 0.267222250213295 no 2467 0.264410571435877 820 688818 SGTC_1091 telmisartan 47.6 µM -0.632284549537962 0.266455587826969 no 2468 0.263600478834518 827 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_475 α-linolenic acid 10 µM -0.632531189150379 0.266379340722115 no 2469 0.263519917418874 801 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_417 st075190 100 µM -0.63366574079222 0.266028743378085 no 2470 0.263149493741643 820 222757 SGTC_2934 9036370 36.88 µM -0.634266581480495 0.265843167255238 no 2471 0.262953430997198 801 6462800 SGTC_1120 ficusin 1.78878 µM -0.634368053179327 0.265811833104163 no 2472 0.26292032673083 827 6199 A DNA cross-linker. SGTC_947 3447-0010 211 µM -0.635005266790498 0.265615106281444 no 2473 0.262712490001312 821 748350 SGTC_1782 st039423 80.636 µM -0.63518668763431 0.265559109770079 no 2474 0.262653332260333 817 2068169 SGTC_3222 9128301 49.47 µM -0.636798976007123 0.265061731572576 no 2475 0.262127896593725 802 4911358 SGTC_1406 3909-7906 11.9 µM -0.640092035060789 0.264047321400168 no 2476 0.261056383448747 814 X1406 SGTC_2685 mycophenolic acid 18.85 µM -0.640561379822207 0.263902903349498 no 2477 0.260903849084099 800 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1066 ketoconazole 628 nM -0.641122078050743 0.263730428506405 no 2478 0.260721685473599 829 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1124 fisetin 1.16336 µM -0.649185265790006 0.261256507659683 no 2479 0.258109317094932 820 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_612 0302-0167 22.4 µM -0.64920329660805 0.261250988894152 no 2480 0.25810349059033 833 235821 SGTC_194 1486-1323 56.904 µM -0.654005259887885 0.259783367610278 no 2481 0.256554208436406 822 5178754 SGTC_1012 4112-3522 18 µM -0.654226228112881 0.259715935751401 no 2482 0.256483033077535 801 3112398 SGTC_3058 9093861 49.47 µM -0.655228118654894 0.259410306789887 no 2483 0.256160446472385 821 17217477 SGTC_2052 5265182 7.135 µM -0.65653793288735 0.259011025415461 no 2484 0.255739034566909 807 1239884 SGTC_782 0083-0095 30.5 µM -0.657705029988482 0.258655517638073 no 2485 0.255363844797976 822 3591729 An indicator and reagent. SGTC_2947 9072639 7.68 µM -0.658336358905084 0.258463314780718 no 2486 0.25516100980026 837 16488146 SGTC_2622 2-methoxyxanthone 59.94 µM -0.658890278378112 0.258294739539231 no 2487 0.254983114526328 807 71034 A hepatoprotective. SGTC_638 3970-0837 4.09 µM -0.662416122075901 0.257223050841405 no 2488 0.253852287096082 817 4118451 YLR208W SEC13 SGTC_3320 9137005 35.139 µM -0.663929266899149 0.256763836735916 no 2489 0.253367791747678 814 4908713 SGTC_1625 st003711 30.1 µM -0.664771601254034 0.256508387404316 no 2490 0.253098294620052 822 24207034 YER133W GLC7 SGTC_2164 5685496 200 µM -0.665685664181251 0.256231335266301 no 2491 0.252806019281642 826 759046 SGTC_2722 naftopidil 47.16 µM -0.666213082213526 0.256071546063306 no 2492 0.252637456100676 834 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1963 st076565 50.3 µM -0.666705653219079 0.255922361240641 no 2493 0.252480083532363 845 4914280 SGTC_1291 0993-0025 5.79 µM -0.672870712569944 0.254058994811377 no 2494 0.250514773024213 816 4353356 SGTC_382 3229-0966 23.2 µM -0.673030359255479 0.25401083690651 no 2495 0.250463988411343 831 5722370 SGTC_2742 clothiapine 36.27 µM -0.673201874053199 0.253959104287064 no 2496 0.250409434557382 809 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1852 st056254 31.4 µM -0.674904330076351 0.253445906217617 no 2497 0.249868274648348 824 442583 SGTC_2754 granisetron 64.02 µM -0.67526593177636 0.253336973149668 no 2498 0.249753412255646 833 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2555 cholic acid 100 µM -0.675415376306087 0.253291959944362 no 2499 0.249705949550294 813 6708657 Influences liver metabolism. SGTC_1556 plumbagin 1.48 µM -0.67550179046 0.253265933623411 no 2500 0.249678507108145 821 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_350 k064-0020 19.8 µM -0.675574669215159 0.253243985003493 no 2501 0.249655364331941 821 2790705 SGTC_355 1311-2252 105 µM -0.675660823986865 0.253218039385838 no 2502 0.249628007203115 838 5338538 SGTC_2941 9056145 11.23 µM -0.676290580438574 0.253028429900004 no 2503 0.249428086052301 824 2119517 SGTC_2371 9071574 200 µM -0.677386792513539 0.25269855644015 no 2504 0.249080287971514 834 45596039 SGTC_2641 levomentholum 100 µM -0.677468546781027 0.252673963925712 no 2505 0.249054359922586 824 16666 SGTC_2765 myclobutanil 7.74 µM -0.678307203515585 0.252421760262246 no 2506 0.24878846613037 851 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2596 sinensetin 100 µM -0.680598330971931 0.251733441630573 no 2507 0.24806284165315 838 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1524 corynanthine 62.1 µM -0.681602109029045 0.251432191226901 no 2508 0.247745290503503 849 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_447 ml7 120 µM -0.683420059355146 0.250887079649354 no 2509 0.247170724112221 839 4216 Selective myosin light chain kinase inhibitor. SGTC_99 0109-0120 622.8 µM -0.684933778403435 0.250433669419974 no 2510 0.246692854825924 842 759414 SGTC_3154 9100113 49.47 µM -0.686436523801179 0.249983976106708 no 2511 0.246218939658936 843 25237525 SGTC_1247 0448-0043 5.84 µM -0.687441896761289 0.249683359828895 no 2512 0.245902151728298 834 3089013 YGL099W LSG1 SGTC_1096 rimcazole 32.2 µM -0.688021374194904 0.249510177711781 no 2513 0.245719660742467 835 18528119 A dopamine reuptake inhibitor. SGTC_551 k048-0028 34.9 µM -0.688705446870602 0.249305818528757 no 2514 0.245504323896601 838 6836383 SGTC_489 paxilline 115 µM -0.688829203076632 0.249268857232274 no 2515 0.245465377946018 835 105008 A toxic potassium channel blocker. SGTC_2977 9011197 71.43 µM -0.690247765687707 0.248845394445455 no 2516 0.245019194958273 838 2704722 SGTC_1414 3917-0015 5.4 µM -0.690565036948907 0.248750736518613 no 2517 0.244919462808846 833 6618702 SGTC_2437 5741531 144.16 µM -0.691662841837415 0.248423354270593 no 2518 0.244574543634936 840 2262990 SGTC_3061 glucosamine 200 µM -0.692994629540172 0.248026503236406 no 2519 0.244156460899222 818 91431 and experimental redox chemotherapeutic SGTC_435 c-PAF 6.7 µM -0.694387163484982 0.247611912828862 no 2520 0.243719720815825 820 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1609 st001574 46.4 µM -0.694887415458385 0.247463066370308 no 2521 0.243562929942917 847 3960012 SGTC_213 1246-0773 967 nM -0.695170785232699 0.247378772903617 no 2522 0.243474139287943 835 6251622 SGTC_1206 3978-0017 132 µM -0.69671786461869 0.246918836892886 no 2523 0.242989688269538 830 3873677 SGTC_3135 9127742 49.47 µM -0.696817492003327 0.246889234052354 no 2524 0.242958508921906 844 3643468 SGTC_2884 9058502 51.95 µM -0.69820311304319 0.246477713741224 no 2525 0.242525089961149 832 6471554 SGTC_2949 9072542 2.23 µM -0.699609243016309 0.246060478443952 no 2526 0.242085684314067 854 16457352 SGTC_622 1348-1566 26.3 µM -0.701086230692855 0.245622626153825 no 2527 0.241624601400301 834 7340407 SGTC_2571 chrysanthemic acid 100 µM -0.701479018374098 0.245506254912765 no 2528 0.241502062072911 860 2743 An insecticide. SGTC_2647 atorvastatin 60.16 µM -0.701754976357059 0.245424514535813 no 2529 0.241415990699265 815 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2189 6047310 154.431 µM -0.702883424007741 0.245090413936424 no 2530 0.241064201012164 829 711535 SGTC_2644 guaiazulene 100 µM -0.703261758782835 0.244978454771269 no 2531 0.240946318863948 826 3515 A coloring agent. SGTC_1987 st072290 61.9 µM -0.703914941840901 0.244785225583736 no 2532 0.240742872866999 840 54697379 SGTC_3148 9097893 49.47 µM -0.705059928015128 0.244446705809024 no 2533 0.240386471330305 805 17174100 SGTC_1690 st023502 41.2 µM -0.705493555506362 0.244318567978233 no 2534 0.240251570533203 838 24207482 SGTC_329 k048-0121 21.3 µM -0.706232758425024 0.244100215457039 no 2535 0.240021700856359 838 6832902 SGTC_2340 7987427 183.45 µM -0.706922957174249 0.243896433283611 no 2536 0.239807178293549 822 2239331 SGTC_1650 st011916 45.8 µM -0.70727763161909 0.243791750861824 no 2537 0.23969698165832 854 242528 SGTC_2651 TUB2.036 5 µM -0.707683192504178 0.243672078996745 no 2538 0.239571008581623 828 15992207 YFL037W TUB2 SGTC_301 4119-0100 24.5 µM -0.708685383495388 0.243376491132758 no 2539 0.239259868626781 848 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3031 9088762 49.47 µM -0.709652107014484 0.24309154779634 no 2540 0.238959949208978 842 205253 SGTC_2027 5150920 200 µM -0.70978728698895 0.243051717660455 no 2541 0.238918026926915 825 786715 SGTC_1997 st073024 93.8 µM -0.710082002619124 0.242964893340383 no 2542 0.238826643074726 836 686268 SGTC_1304 1165-0502 251 µM -0.710396137203943 0.242872366600505 no 2543 0.238729258950211 837 767425 SGTC_2958 9077254 16.72 µM -0.711030229303228 0.242685656107148 no 2544 0.238532751753529 831 16457351 SGTC_1275 0867-0008 21.1 µM -0.713007302407307 0.24210399965352 no 2545 0.237920619215301 837 3422836 SGTC_2678 equilin 100 µM -0.714667688486427 0.241616097348773 no 2546 0.237407204024001 809 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1216 1165-0504 9.65 µM -0.715563948502181 0.241352954519778 no 2547 0.237130320562643 851 6304004 SGTC_2626 ethyl orsellinate 100 µM -0.716692983235421 0.241021690543383 no 2548 0.236781778200177 860 75653 A natural product. SGTC_1214 0358-0031 63.7 µM -0.716978474604502 0.240937965245868 no 2549 0.236693689300181 868 4301366 SGTC_1178 0988-0033 191 µM -0.717770593244736 0.240705745570572 no 2550 0.236449374020265 834 5392207 SGTC_2799 7812892 81.82 µM -0.719362273630408 0.240239492713893 no 2551 0.235958867712108 854 20205235 SGTC_2610 ononetin 44.17 µM -0.719974372771583 0.240060320883302 no 2552 0.235770387226607 856 259632 SGTC_356 1634-0012 32.5 µM -0.720122203576249 0.240017059216885 no 2553 0.235724878909365 848 735457 SGTC_1929 genistein trimethyl ether 50.5 µM -0.721117429279618 0.239725923942534 no 2554 0.235418634184728 833 136420 SGTC_2845 9003024 42.97 µM -0.721235825720777 0.239691302036071 no 2555 0.235382216581362 826 2990173 SGTC_1736 st036774 51 µM -0.722215234630022 0.239405004493595 no 2556 0.235081079128947 853 1272247 SGTC_45 0kpi-0036 14.9 µM -0.722420383661919 0.239345059679078 no 2557 0.23501802921755 839 2795021 SGTC_2158 5657123 3.6195 µM -0.72293131806193 0.239195799625115 no 2558 0.234861040729971 865 2858827 SGTC_3096 9117468 49.47 µM -0.723707221519174 0.238969231055387 no 2559 0.234622749358805 836 41316311 SGTC_2452 5863136 48.41 µM -0.724957537954262 0.238604378012992 no 2560 0.234239040270094 846 2184096 SGTC_800 3448-7362 155 µM -0.725336951790708 0.238493722131409 no 2561 0.234122670856996 852 15991913 SGTC_2816 7982706 58.44 µM -0.726662429466808 0.238107367745154 no 2562 0.233716387093435 852 2981853 SGTC_3338 9144300 39.5675 µM -0.726672534230847 0.238104423694842 no 2563 0.233713291295609 833 4901274 SGTC_2738 aclarubicin 5.55 µM -0.727548296041813 0.23784934392497 no 2564 0.233445070414981 811 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1492 4158-0558 28.5 µM -0.727887247856556 0.237750658974084 no 2565 0.233341304987713 819 3967268 SGTC_2700 st077718 96.8 µM -0.72863203466225 0.237533895124748 no 2566 0.233113388697359 845 904970 SGTC_105 0111-0055 734.78 µM -0.729010813253108 0.237423696468954 no 2567 0.23299752401586 840 5179370 SGTC_2430 5571206 200 µM -0.729312867952052 0.237335839335963 no 2568 0.23290515135161 846 1731771 SGTC_2746 daunorubicin 9.88 µM -0.729474852506355 0.237288731057529 no 2569 0.232855622530167 808 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1501 4491-0275 38.4 µM -0.729554485275551 0.237265574172769 no 2570 0.232831275951771 849 5104718 SGTC_3022 9087993 49.47 µM -0.731258914142148 0.236770230909164 no 2571 0.232310510477614 853 17173644 SGTC_958 1222-0007 33 µM -0.731952995875335 0.236568679073731 no 2572 0.232098628895114 852 7312461 SGTC_1948 st076329 66.6 µM -0.734556450699331 0.235813513263271 no 2573 0.231304834315409 837 24208413 SGTC_1004 4084-0029 199 µM -0.73484031872554 0.235731254095531 no 2574 0.231218374474369 847 716894 YLR208W SEC13 SGTC_2789 5281112 71.43 µM -0.735348474096162 0.235584040551229 no 2575 0.231063646770231 846 765948 SGTC_1071 trifluoperazine 6.31 µM -0.736689568757964 0.235195766619646 no 2576 0.230655575882501 866 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1167 k781-0610 148 µM -0.736913479294922 0.235130974449611 no 2577 0.230587483196506 841 4525169 SGTC_789 1309-1135 70.6 µM -0.742003710918558 0.233660695246892 no 2578 0.229042543611958 840 3092424 SGTC_644 1498-1197 63.3 µM -0.744932171879368 0.232817144161238 no 2579 0.22815636252953 857 6741615 SGTC_2277 7947813 106.88 µM -0.746451743704725 0.232380095082407 no 2580 0.227697285940654 856 1246798 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.750536222911169 0.231207609491481 no 2581 0.226465908060053 860 521171 SGTC_2298 7976326 193.81 µM -0.750627515317112 0.231181440970315 no 2582 0.226438428498758 840 2235818 SGTC_1315 1237-0019 3.69 µM -0.753128154618292 0.230465287885783 no 2583 0.225686453623509 838 825140 SGTC_893 0958-0369 48.9 µM -0.753599829233736 0.23033034508698 no 2584 0.225544773454776 851 6819948 SGTC_1333 1482-0047 286 µM -0.755935105338382 0.229662890253961 no 2585 0.224844052448867 870 3811116 SGTC_502 l-744,832 89.3 µM -0.75705274935672 0.22934383555558 no 2586 0.224509130302091 880 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3146 9095609 49.47 µM -0.757858715108254 0.229113910172372 no 2587 0.22426778393445 861 17173999 SGTC_597 k018-0003 82.8 µM -0.758780373469581 0.228851138614479 no 2588 0.223991974051036 860 6786234 SGTC_234 nsc-17383 10.7 µM -0.759702623724672 0.228588367705661 no 2589 0.223716180043304 833 408974 SGTC_1526 st051518 75 µM -0.760461014730445 0.228372411204234 no 2590 0.223489531995948 865 673993 SGTC_1079 idarubicin 2.36 µM -0.761209754566872 0.22815931545156 no 2591 0.223265896429608 876 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1507 4075-3230 155 µM -0.761703931226627 0.228018731140942 no 2592 0.223118364257966 846 659771 SGTC_2692 st077426 47.7 µM -0.7638864016675 0.227398440898365 no 2593 0.222467470848833 857 25238571 SGTC_1033 k072-0102 21.3 µM -0.763914896832066 0.227390348444463 no 2594 0.222458979704525 854 5965931 SGTC_58 0957-0393 9 µM -0.764952683137131 0.227095734000507 no 2595 0.22214986045933 855 6997992 SGTC_3015 9080845 49.47 µM -0.766158977694853 0.226753552796201 no 2596 0.221790856948478 857 5296973 SGTC_339 3091-4833 71.4 µM -0.766222064360991 0.2267356654482 no 2597 0.221772090944319 858 3240077 SGTC_807 1315-0151 48 µM -0.766485442084915 0.226660996953922 no 2598 0.221693755384953 879 4011080 SGTC_481 bay k-8644 50 µM -0.766512746740081 0.22665325678392 no 2599 0.221685635156873 864 2303 A calcium channel antagonist. SGTC_8 0354-0001 70 µM -0.767086598449573 0.226490619047854 no 2600 0.221515014688038 854 4993152 SGTC_22 0964-0034 14.468 µM -0.767089018983697 0.226489933173642 no 2601 0.221514295161708 869 138402 SGTC_1170 0310-0127 64.8 µM -0.772519587643331 0.224954101623556 no 2602 0.219903375092259 878 774975 SGTC_2621 lithochol-11-enic acid 100 µM -0.77654937323531 0.22381825434896 no 2603 0.218712340259085 874 6708711 SGTC_2008 4012253 172 µM -0.777279792766251 0.223612725680086 no 2604 0.218496857178881 857 603940 SGTC_1210 3013-0140 750 nM -0.777500497218728 0.223550644009396 no 2605 0.218431770608575 848 905973 SGTC_3118 9124250 49.47 µM -0.777868224855181 0.223447228154005 no 2606 0.218323351155677 839 1504786 SGTC_586 0957-0265 8.15 µM -0.784674385172023 0.221538055419331 no 2607 0.216322252375518 858 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_962 1254-0300 21.5 µM -0.785038046606448 0.22143630908044 no 2608 0.216215630880368 836 7340576 SGTC_2491 paeonol 100 µM -0.787140782449323 0.220848523145841 no 2609 0.215599728996914 881 11092 Increases levels of cortical cytochrome oxidase. SGTC_1254 0550-0035 264 µM -0.787811523482258 0.220661216390205 no 2610 0.2154034798059 882 15121435 SGTC_552 k242-0005 476 µM -0.789217053930838 0.220269012421137 no 2611 0.214992578071071 885 4088318 SGTC_1824 st053723 68.6 µM -0.793394577644762 0.219105664405355 no 2612 0.2137739844722 863 675225 SGTC_2159 5658611 73.75 µM -0.794740713912722 0.218731549183106 no 2613 0.213382171948257 891 793844 SGTC_762 1165-0429 115 µM -0.794846983605359 0.218702030609644 no 2614 0.213351258448659 865 5967793 SGTC_2482 5981709 142.65 µM -0.795406622158856 0.21854661742843 no 2615 0.213188504542655 889 877755 SGTC_775 4577-0580 57.3 µM -0.7954466996531 0.218535490237385 no 2616 0.213176851997594 869 2006902 SGTC_2472 5377652 49.4 µM -0.795453381388038 0.218533635139629 no 2617 0.213174909317021 896 1610903 SGTC_534 k292-0788 63.4 µM -0.796934473727887 0.218122652719909 no 2618 0.212744544091362 892 4146317 SGTC_27 0485-0001 32.618 µM -0.798357283209243 0.217728262837191 no 2619 0.212331592379242 852 2054479 SGTC_1352 1496-0991 99 µM -0.7995696117803 0.217392541202143 no 2620 0.211980099877958 874 3000039 SGTC_1655 st012546 55.1 µM -0.802703742932246 0.216526014724052 no 2621 0.211072994521684 874 720985 YLR208W SEC13 SGTC_1059 3448-6867 171 µM -0.804687236824086 0.215978651265006 no 2622 0.210500093279877 871 3934407 SGTC_1274 0865-0114 173 µM -0.804809546838286 0.2159449249477 no 2623 0.210464795841253 854 870624 SGTC_746 1095-0025 46.6 µM -0.805264152622152 0.215819596641073 no 2624 0.210333631646506 871 6749286 SGTC_2524 avocatin b 10.57 µM -0.806056889781652 0.215601151234341 no 2625 0.210105023648931 841 6710748 SGTC_2343 7990716 14.84 µM -0.806780316385411 0.215401916868662 no 2626 0.209896530731332 891 6456862 SGTC_1491 4138-0063 26.5 µM -0.807584816875036 0.215180479941852 no 2627 0.209664815032415 869 23883227 SGTC_1445 4239-0156 97.7 µM -0.808441665763355 0.214944779613352 no 2628 0.209418187228405 896 4008346 SGTC_1809 st050081 57.6 µM -0.808611407597652 0.214898105159667 no 2629 0.209369350505563 870 5036894 SGTC_1350 1495-0454 146 µM -0.810163074020886 0.21447171145133 no 2630 0.208923228565189 860 1069057 SGTC_1305 1181-0477 144 µM -0.810168956150851 0.214470095994518 no 2631 0.208921538451301 887 6252086 SGTC_647 0140-0236 81 µM -0.811904343646666 0.21399380155464 no 2632 0.20842326092273 874 990837 SGTC_599 1935-0052 86.5 µM -0.813515090196903 0.213552267539551 no 2633 0.20796139902007 872 9557311 SGTC_1816 st051957 91.6 µM -0.814314603876009 0.213333304041264 no 2634 0.207732372819404 900 674121 SGTC_391 gliotoxin 8.33 µM -0.815972758652456 0.212879601235149 no 2635 0.207257858165486 900 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3352 9151559 45.5865 µM -0.816225865760624 0.212810395873486 no 2636 0.207185482858767 857 17159339 SGTC_3203 9113543 49.47 µM -0.818076029477452 0.212304917155239 no 2637 0.206656887620704 883 17018012 SGTC_996 3970-0799 1.8 µM -0.818418962852783 0.212211302307349 no 2638 0.206558998719935 874 6615648 YGL040C HEM2 SGTC_787 4152-0075 138 µM -0.820641288910442 0.211605231057679 no 2639 0.205925310995006 862 9566539 SGTC_1336 1486-0901 104 µM -0.821069901268192 0.211488456855439 no 2640 0.205803226617356 864 5006114 SGTC_2967 9089538 49.85 µM -0.824762510161457 0.210483980186675 no 2641 0.204753217373337 879 728216 SGTC_2853 9015042 58.44 µM -0.82484491212866 0.210461596896768 no 2642 0.204729822423124 865 6457456 SGTC_2829 7992743 58.44 µM -0.825354124056304 0.210323307916969 no 2643 0.204585286056698 888 16462845 SGTC_2198 6589944 200 µM -0.8258091749087 0.21019977285923 no 2644 0.204456174332281 869 5290268 SGTC_1267 0828-0272 9.49 µM -0.825964882067193 0.210157512002651 no 2645 0.204412006628932 883 745334 SGTC_2354 9060492 162 µM -0.826482056604784 0.210017180232727 no 2646 0.204265346293905 901 6471895 SGTC_2854 9024559 71.43 µM -0.826566197111228 0.209994354491105 no 2647 0.204241491659866 893 3163529 SGTC_411 enrofloxacin 100 µM -0.826717804116218 0.209953230033434 no 2648 0.204198513819304 864 71188 A bacterial gyrase inhibitor. SGTC_3289 9119912 71.43 µM -0.827585853706959 0.209717856671684 no 2649 0.203952541199516 889 17014829 SGTC_3331 9141060 1.957 µM -0.827847190745171 0.209647025015973 no 2650 0.203878522700126 879 4906567 YPR165W RHO1 SGTC_335 4077-0256 27.6 µM -0.827969291228022 0.209613936254205 no 2651 0.203843945663703 875 3121989 SGTC_244 nsc-207895 1.295 µM -0.828958652574506 0.209345936425887 no 2652 0.203563902202969 835 42640 SGTC_1432 4049-0298 68.4 µM -0.829008575343406 0.2093324186106 no 2653 0.203549777408304 882 741646 SGTC_2096 5468907 200 µM -0.829074086633682 0.209314680599826 no 2654 0.203531242994662 879 759785 SGTC_189 3970-0742 2.116 µM -0.829896371489171 0.209092111817111 no 2655 0.203298688296112 864 2891807 SGTC_2260 7964312 200 µM -0.829981013546905 0.209069209567943 no 2656 0.203274759235884 870 231951 SGTC_2175 5807670 165.306 µM -0.830658152522075 0.208886044081759 no 2657 0.203083386564014 832 241186 SGTC_175 3793-3120 23.7 µM -0.831285494851856 0.208716432939556 no 2658 0.202906183425806 894 5322297 SGTC_1023 4482-3888 16 µM -0.833815211734739 0.20803331116231 no 2659 0.20219256099716 879 3303168 SGTC_1513 0337-0559 19 µM -0.833830315598103 0.208029236500367 no 2660 0.202188304775514 878 775073 SGTC_483 fpl-64176 144 µM -0.834037075723 0.207973462289037 no 2661 0.202130045805848 898 3423 SGTC_1510 1123-0200 71.5 µM -0.839238434311183 0.206573285754852 no 2662 0.200667761771442 891 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3037 9091026 49.47 µM -0.842157714650345 0.205789884167874 no 2663 0.199849839636798 880 25236398 YIL048W NEO1 SGTC_1889 st059080 5.18 µM -0.842285615333871 0.205755601820764 no 2664 0.199814050412426 873 176925 Isolated from Daphnopsis sellowiana. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.845983296998322 0.204765945680753 no 2665 0.198781031127217 844 6708630 An antioxidant. SGTC_1346 1488-2224 62.4 µM -0.847444688018193 0.204375597467789 no 2666 0.19837365245009 869 3722427 SGTC_1548 st061468 90.8 µM -0.853260910040167 0.202826437621385 no 2667 0.196757316143541 888 390799 SGTC_2449 5812982 45.77 µM -0.853966169013188 0.202639068854484 no 2668 0.196561867334907 898 776185 SGTC_615 k087-0205 167 µM -0.854530127924676 0.202489314261232 no 2669 0.196405661762669 889 9642773 SGTC_685 1278-0033 54.9 µM -0.854712802780182 0.202440820665328 no 2670 0.196355080542293 897 3590572 SGTC_2876 9059903 25.97 µM -0.854740852994394 0.202433374958619 no 2671 0.196347314359564 857 6916095 SGTC_510 ag-490 170 µM -0.855862738666343 0.202135713574262 no 2672 0.196036853742564 880 5328779 SGTC_32 0928-0142 34.1 µM -0.859949547789685 0.201053608308672 no 2673 0.194908427103252 878 2244242 SGTC_2707 st078556 66.6 µM -0.861861446703296 0.200548571000609 no 2674 0.194381883306652 868 17250899 SGTC_48 0382-0018 55 µM -0.862750963130427 0.200313860850634 no 2675 0.19413720276757 892 762596 SGTC_3099 9120367 49.47 µM -0.862863547946358 0.200284165694992 no 2676 0.194106247284465 895 24824940 SGTC_2955 9076254 12.21 µM -0.863191126145411 0.200197779341406 no 2677 0.194016195924331 873 16459619 SGTC_2308 7584454 197.62 µM -0.863365605450219 0.200151776168709 no 2678 0.19396824189472 892 893577 SGTC_469 w7 172 µM -0.864266382489672 0.19991437859357 no 2679 0.193720786537593 879 45115570 A P450 inhibitor. SGTC_1927 st060202 13.8 µM -0.865304707779353 0.199640940702139 no 2680 0.193435783786905 872 688887 SGTC_2223 6903751 107.57 µM -0.865815002551572 0.199506639586141 no 2681 0.193295810292903 888 5598863 SGTC_1310 1188-0297 994 nM -0.866115345917763 0.199427619624551 no 2682 0.193213455224774 876 1588352 SGTC_2374 9071832 200 µM -0.868980198330934 0.198674827990063 no 2683 0.192428980833836 873 17381698 SGTC_645 0845-0943 5.41 µM -0.869228125577152 0.198609761298091 no 2684 0.192361183302378 887 1885106 SGTC_2873 9040596 71.43 µM -0.869654231468364 0.19849796295475 no 2685 0.192244695639449 902 6463863 SGTC_3301 9125354 19.7965 µM -0.870280272718742 0.198333776011272 no 2686 0.192073628481308 862 41905162 SGTC_2319 6033012 152.6 µM -0.871227557653283 0.198085494886683 no 2687 0.191814957943663 906 847246 SGTC_545 4218-0007 221 µM -0.873894164620805 0.197387591965585 no 2688 0.191087946431579 909 2840508 SGTC_322 k048-0136 19.3 µM -0.874331852125095 0.197273182867426 no 2689 0.19096877895327 906 6823282 SGTC_1702 st027038 51 µM -0.874359157726559 0.197266046663497 no 2690 0.190961346074033 891 5521182 SGTC_2642 cholecalciferol 100 µM -0.874611697622426 0.19720005382665 no 2691 0.190892610400887 874 9821465 A vitamin D precursor, similar to steriods. SGTC_1092 toremifene 6.32 µM -0.880411784326396 0.195688074313291 no 2692 0.189318137448191 916 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1819 st053448 58.6 µM -0.880869172157941 0.195569141547469 no 2693 0.189194317396373 930 2857616 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.881101603296865 0.195508720212145 no 2694 0.189131414774623 880 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1015 4130-4525 82 µM -0.88131524529888 0.195453193182697 no 2695 0.189073608400459 897 1363237 SGTC_568 1193-0097 7.48 µM -0.883835790845336 0.194798809385826 no 2696 0.188392431335598 858 3646150 SGTC_2812 7970281 58.44 µM -0.88432637532226 0.194671598991423 no 2697 0.188260027147629 928 2233435 SGTC_2259 7964009 200 µM -0.884726413597547 0.19456790498697 no 2698 0.188152103045194 885 313134 SGTC_345 1362-0200 395 µM -0.887655226213926 0.19380975122362 no 2699 0.187363118545677 923 1419823 SGTC_2255 7941087 197.44 µM -0.88841674111387 0.193612920508008 no 2700 0.187158311714849 911 935561 SGTC_1157 4092-0394 27.6 µM -0.889551163166508 0.193319929685962 no 2701 0.186853469651479 905 3659885 SGTC_3018 9082602 49.47 µM -0.890999906740583 0.192946151679473 no 2702 0.186464610132861 886 17332089 SGTC_3095 9117207 49.47 µM -0.891082188278949 0.192924936173688 no 2703 0.186442539869484 899 17015229 SGTC_252 miconazole 1.30953 nM -0.892057550091474 0.192673557040832 no 2704 0.186181043203256 877 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2204 7233102 200 µM -0.892841229394052 0.192471725164075 no 2705 0.185971101814879 881 2172480 SGTC_2022 5136654 200 µM -0.892958874791625 0.192441437464137 no 2706 0.185939598234257 907 1713771 SGTC_1743 st037606 46.3785 µM -0.893003614641619 0.192429919995562 no 2707 0.185927618477141 886 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1053 3366-3204 134 µM -0.895479668963432 0.191793161670793 no 2708 0.185265364633823 920 3632071 YPR165W RHO1 SGTC_1061 3448-9325 110 µM -0.896038866613805 0.191649533525706 no 2709 0.185116002748706 882 723482 SGTC_184 1494-0393 24.714 µM -0.898564984179133 0.191001529568616 no 2710 0.184442208438737 901 3090647 SGTC_169 k015-0017 16.025 µM -0.898790320149163 0.190943791359673 no 2711 0.184382178513385 928 1840002 SGTC_2483 5729050 27.16 µM -0.899252649359538 0.190825361502749 no 2712 0.184259051202989 891 2865180 SGTC_1149 3909-7961 23.3 µM -0.899346496121482 0.190801327300001 no 2713 0.184234064223571 904 735261 SGTC_2208 7283366 200 µM -0.899780027274984 0.190690323865499 no 2714 0.184118662638077 877 898663 SGTC_2050 5263056 171 µM -0.900687317987984 0.190458145024162 no 2715 0.183877296736021 880 763468 YGL055W OLE1 SGTC_154 3389-1638 511.116 µM -0.904283378099399 0.189539609471603 no 2716 0.182922579148611 939 5238686 SGTC_2679 rapamycin 1 nM -0.905932741502513 0.189119228681417 no 2717 0.182485726555568 870 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_254 nsc-64875 3.808 µM -0.908870348372799 0.188371930794345 no 2718 0.181709283612256 902 56993 SGTC_501 nsc-95397 161 µM -0.910238376142344 0.188024540681999 no 2719 0.181348404771174 899 262093 SGTC_2373 9071805 200 µM -0.910721078614243 0.187902060085348 no 2720 0.18122117746974 926 10149009 SGTC_367 0335-0881 7.1 µM -0.911021666820788 0.187825813935028 no 2721 0.181141978809633 912 23828853 SGTC_730 1436-0052 41.2 µM -0.912690758600931 0.187402785665466 no 2722 0.180702602833522 881 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3277 9138724 49.47 µM -0.912791975839751 0.187377151294635 no 2723 0.180675979656543 884 15943418 SGTC_246 cycloheximide 667 µM -0.913406467614928 0.187221571072597 no 2724 0.180514402639588 891 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_829 1635-0120 117 µM -0.915168032911203 0.186776011715808 no 2725 0.18005171188085 893 285054 SGTC_543 3844-1095 191 µM -0.917950622068834 0.186073539444839 no 2726 0.179322358735027 917 4230703 SGTC_983 1491-0821 12.2 µM -0.918182485986577 0.186015078775661 no 2727 0.179261668124125 902 46495113 SGTC_1293 1000-1278 195 µM -0.918952540706139 0.185821003879447 no 2728 0.179060198242104 912 678847 SGTC_2015 5119600 184 µM -0.91943382949027 0.185699769712975 no 2729 0.178934350738854 919 2828786 SGTC_3261 9137475 49.47 µM -0.920495353862635 0.18543255070827 no 2730 0.178656979928698 848 17027690 SGTC_1996 st072960 66.8 µM -0.921019237916129 0.185300760659901 no 2731 0.178520191576889 890 1719405 SGTC_1903 st060211 78.3 µM -0.921329024939096 0.185222856956697 no 2732 0.178439335914875 892 688960 SGTC_2918 7977171 22.06 µM -0.922279824685426 0.184983881594435 no 2733 0.178191317441942 892 2236483 SGTC_1637 st007924 17.4 µM -0.926339917264679 0.183965569322584 no 2734 0.177134678803126 884 683336 SGTC_2611 pyromycin 23.93 µM -0.92661526298064 0.183896636452621 no 2735 0.177063163707081 901 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1427 4048-4900 550 nM -0.928653159948874 0.183386948666798 no 2736 0.176534431285437 903 24132586 SGTC_366 0181-0206 4.31 µM -0.929848156879329 0.183088484258926 no 2737 0.176224854250843 925 274874 SGTC_1181 1222-0449 220 µM -0.931106013759664 0.18277464741332 no 2738 0.175899364062464 935 658318 SGTC_1988 st071872 53.4 µM -0.932374448409341 0.182458511692869 no 2739 0.175571522520212 910 16414116 SGTC_249 wiskostatin 11.211 µM -0.932931795571205 0.182319710493985 no 2740 0.175427592262796 885 2775510 A n-wasp and actin depolymerizer. SGTC_2065 5221596 34.26 µM -0.93323651426999 0.182243851548447 no 2741 0.17534893283456 906 788581 SGTC_759 3486-0358 89.3 µM -0.933703125702604 0.182127728054284 no 2742 0.175228526111045 920 875103 SGTC_2031 5180455 200 µM -0.93491637713905 0.18182600815936 no 2743 0.17491569818715 943 29949 SGTC_2973 9094665 17.96 µM -0.935425193480152 0.181699565245678 no 2744 0.174784609198526 892 25237061 YIL048W NEO1 SGTC_2306 7482397 179.52 µM -0.938168832604945 0.181018708362473 no 2745 0.17407882637661 965 891448 SGTC_3128 9127691 49.47 µM -0.939087781913376 0.180791021284243 no 2746 0.17384283839594 914 41316314 SGTC_676 falcarinol 140 µM -0.940673700806396 0.180398502354238 no 2747 0.173436050132779 913 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3171 9103192 49.47 µM -0.940946782575909 0.180330967925609 no 2748 0.173366065843123 916 13018434 SGTC_1691 st019933 84.6 µM -0.942375494563689 0.179977899281699 no 2749 0.173000214451643 943 6176082 SGTC_214 4373-3496 70 µM -0.943031049193862 0.179816041554815 no 2750 0.172832510811251 924 3779166 SGTC_2109 5483026 200 µM -0.944346660517304 0.179491490515685 no 2751 0.172496264536232 923 759335 SGTC_725 1497-0963 19 µM -0.944503320593169 0.179452868247096 no 2752 0.172456252891842 899 3549977 SGTC_1904 st060225 78 µM -0.9465106589998 0.178958450513988 no 2753 0.171944094127862 899 66595 SGTC_2653 dihydrofissinolide 100 µM -0.951367257816737 0.177765795357939 no 2754 0.170708987682908 929 6857746 SGTC_2787 5284540 71.43 µM -0.953747221326342 0.177183172812791 no 2755 0.1701058055281 938 736958 SGTC_715 0868-0130 184 µM -0.956513997872994 0.176507375146123 no 2756 0.169406307889611 956 2876258 SGTC_2856 9022925 19.48 µM -0.958041064364337 0.176135081433863 no 2757 0.169021026029381 928 4944862 SGTC_663 1486-0733 13.9 µM -0.96021467841883 0.175606019559833 no 2758 0.16847359042441 915 722445 YPR165W RHO1 SGTC_2891 9063876 19.48 µM -0.962388867555196 0.175077826247148 no 2759 0.167927151815864 909 6472478 SGTC_3325 9138760 55.175 µM -0.962894031009916 0.174955247249442 no 2760 0.167800352678901 894 43844959 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.964619936727166 0.174536863506066 no 2761 0.167367604952097 895 756377 SGTC_3104 9120930 49.47 µM -0.9654631706477 0.174332683035734 no 2762 0.167156437111591 912 17014836 SGTC_1606 st000094 49.2 µM -0.968907942505813 0.173500143920888 no 2763 0.166295561140711 910 1242210 SGTC_110 0850-0284 111.64 µM -0.969234914152523 0.173421252483883 no 2764 0.166213997367328 865 3906265 SGTC_1035 k081-0041 55.2 µM -0.969845637861017 0.173273958761554 no 2765 0.166061720257231 896 731709 SGTC_2328 6201408 200 µM -0.972214382855961 0.172703421175565 no 2766 0.165471953360341 948 2890418 SGTC_2047 4141938 200 µM -0.972436358135121 0.172650017492848 no 2767 0.165416755776896 930 3807862 SGTC_165 k038-0023 64.381 µM -0.97360868383334 0.172368149437905 no 2768 0.165125436487057 935 46368543 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.974920978742968 0.172052976323095 no 2769 0.164799729486695 906 5379071 SGTC_2142 5622915 118.518 µM -0.975457313986775 0.171924270958776 no 2770 0.164666732835219 919 5322196 SGTC_331 k048-0133 24.5 µM -0.976247956513019 0.171734651141541 no 2771 0.164470801704826 915 6813582 SGTC_1642 st009582 77.7 µM -0.977625695777486 0.171404547237049 no 2772 0.164129741879509 924 6739311 SGTC_54 0159-0055 9 µM -0.980469880238942 0.170724369417554 no 2773 0.163427115126753 917 3319099 SGTC_869 0564-0080 44.1 µM -0.98211108905546 0.17033266662886 no 2774 0.163022561506297 911 6843321 SGTC_1436 4092-1007 8.32 µM -0.983242510635419 0.170062968857957 no 2775 0.16274404849572 899 2881121 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.983840441831132 0.169920550171946 no 2776 0.162596985617463 895 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2191 5911152 200 µM -0.987525270174726 0.169044564826701 no 2777 0.161692600463008 917 2875902 SGTC_2650 prasterone 100 µM -0.988522385413925 0.168808022518325 no 2778 0.161448438381582 906 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2366 9070441 60.58 µM -0.989164271531161 0.168655862603162 no 2779 0.1612913879769 917 6837235 SGTC_2723 salbutamol 83.58 µM -0.990420727866127 0.16835827329544 no 2780 0.160984259093756 912 9884233 β2-adrenoceptor agonist SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.993813625990708 0.167556360175779 no 2781 0.160156805560886 945 689007 SGTC_253 dyclonine 31.25 µM -0.99739721131748 0.166712054424207 no 2782 0.159285872210227 926 3180 An oral anasthetic. SGTC_430 0958-0115 16.4 µM -0.998944041876807 0.166348465223435 no 2783 0.158910899787995 932 6833180 SGTC_2803 7707263 71.43 µM -0.999449238513063 0.166229827585334 no 2784 0.15878855878697 935 2199229 SGTC_3296 9122258 64.045 µM -0.999634881900549 0.166186245833273 no 2785 0.158743617951223 936 4730474 SGTC_1282 0886-0010 32.4 µM -1.00085151338497 0.165900811409319 no 2786 0.158449300344214 913 2836211 YNL267W PIK1 SGTC_1989 st071868 50.2 µM -1.00125355520983 0.165806557903866 no 2787 0.158352120385538 916 16414057 SGTC_152 4469-0003 551.229 µM -1.0031376761969 0.165365311450432 no 2788 0.157897219249168 907 697280 SGTC_2301 7769476 200 µM -1.00415000405852 0.16512854621811 no 2789 0.157653158111161 928 977820 SGTC_1387 3342-1166 1.8 µM -1.00584094810861 0.164733554545209 no 2790 0.157246043080555 914 3418228 SGTC_79 0052-0007 94.094 µM -1.00627646217012 0.164631920980013 no 2791 0.157141299896107 898 2801472 SGTC_760 0568-0725 82.9 µM -1.00701917180386 0.16445869258908 no 2792 0.156962780596001 940 3916171 SGTC_2378 9074213 121.43 µM -1.00723956999458 0.164407310012879 no 2793 0.156909830888387 926 657714 SGTC_806 3966-4455 5.86 µM -1.00798646344132 0.164233260260638 no 2794 0.156730480386058 929 714982 SGTC_1924 st058459 75.1 µM -1.00927909283707 0.163932319255906 no 2795 0.156420401994479 922 688683 SGTC_1411 3909-8223 150 µM -1.00940142359152 0.163903857604042 no 2796 0.156391078001125 928 X1411 SGTC_1040 k898-0338 155 µM -1.00973738467553 0.163825708904633 no 2797 0.156310563153669 920 20969351 SGTC_2201 6605497 169.863 µM -1.01333535768633 0.162990292535312 no 2798 0.155450002174873 935 670741 SGTC_3153 9100258 49.47 µM -1.0148489332856 0.162639683186437 no 2799 0.155088921970327 941 25236848 SGTC_2314 7727897 200 µM -1.01819677562856 0.16186592275426 no 2800 0.15429222573892 894 900724 SGTC_1250 0485-0349 40.2 µM -1.01834236430987 0.161832328496797 no 2801 0.154257641072986 938 6842794 YDL195W SEC31 SGTC_3143 9086658 49.47 µM -1.01991505714929 0.161469722821582 no 2802 0.153884373909331 921 25236626 SGTC_530 4358-1714 28 µM -1.02188808400468 0.161015564508715 no 2803 0.153416936440805 905 1564641 SGTC_1644 st010134 20.9 µM -1.02308344125609 0.160740818878042 no 2804 0.153134197704787 939 3818134 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.02309279824739 0.16073866943845 no 2805 0.153131985851815 948 688751 SGTC_1102 cgs 12066b 26.1 µM -1.0232586667922 0.16070057009047 no 2806 0.15309278052001 918 6438352 A 5-HT1B full agonist. SGTC_270 tamoxifen 5.46 µM -1.02345175995168 0.160656224785649 no 2807 0.15304714865418 964 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1808 st050063 61.5 µM -1.02663660927898 0.159925953190223 no 2808 0.152295804387359 934 4011993 SGTC_3088 9117578 49.47 µM -1.02667046578022 0.159918201727899 no 2809 0.152287830407167 968 678341 SGTC_3292 9120825 59.784 µM -1.02909925303814 0.159362770845265 no 2810 0.151716518573245 911 24824900 SGTC_1451 4152-0210 104 µM -1.02924142092619 0.159330298146349 no 2811 0.15168312129707 954 659563 SGTC_1233 0325-0408 14.2 µM -1.02991560522982 0.159176366081076 no 2812 0.151524812263455 938 12874 SGTC_2321 7390090 138.78 µM -1.03118899617498 0.158885886946987 no 2813 0.151226099902897 960 649046 SGTC_1370 2001-0092 44.6 µM -1.03208681639063 0.158681289956921 no 2814 0.151015724634759 929 790957 SGTC_2190 6049624 200 µM -1.03221897310289 0.158651188423189 no 2815 0.150984774414979 914 2265554 SGTC_1555 citronellol 128 µM -1.03227004610313 0.158639556451994 no 2816 0.150972814590298 938 8842 A terpine precursor. SGTC_2246 7293507 91.5585 µM -1.03551673499468 0.157901264686194 no 2817 0.150213827567904 936 887656 SGTC_1618 st003135 44.5 µM -1.03764195281723 0.157419217370376 no 2818 0.149718389333198 948 1270615 SGTC_1752 st044819 83.042 µM -1.03780919661218 0.157381323804082 no 2819 0.149679447196088 929 441209 YML126C ERG13 SGTC_1378 2093-0007 380 nM -1.03963871956518 0.156967187898378 no 2820 0.149253890460531 954 3618014 SGTC_2220 6782180 200 µM -1.04072133887178 0.156722461116455 no 2821 0.149002448323416 919 833803 SGTC_1693 xanthone 101.9 µM -1.04184366398453 0.156469024061499 no 2822 0.148742083281613 951 7020 An insecticide. SGTC_3163 9099914 49.47 µM -1.04242660431759 0.156337494349438 no 2823 0.14860696865752 967 16268368 SGTC_2881 9058953 51.95 µM -1.04270381053635 0.156274973446165 no 2824 0.148542746257329 908 17122249 SGTC_432 NS 1619 61.3 µM -1.04272633357774 0.156269894338201 no 2825 0.148537528994236 924 4552 A K+/calcium channel activator. SGTC_2551 apiole 73.87 µM -1.04503624255351 0.155749570695667 no 2826 0.148003109653395 919 10659 A possible DNA adduct former. SGTC_3183 9108214 49.47 µM -1.0457525280061 0.155588454558276 no 2827 0.147837651961721 937 4974831 SGTC_1833 st055984 71 µM -1.04592254726405 0.155550227790113 no 2828 0.147798396715302 935 676288 SGTC_2078 5212016 200 µM -1.04647900386821 0.155425158597045 no 2829 0.147669966893109 934 1899708 SGTC_3172 9105863 49.47 µM -1.04763729303811 0.155165034373593 no 2830 0.147402874288782 969 2348785 SGTC_812 4251-0442 148 µM -1.04973427758609 0.154694833041243 no 2831 0.146920149734903 966 5723007 SGTC_2463 5473429 200 µM -1.04992404827488 0.154652327764267 no 2832 0.146876517017266 927 5399405 SGTC_1608 st001473 40.5 µM -1.04997231174918 0.154641518831007 no 2833 0.146865421502791 958 7292267 SGTC_2878 9043973 25.97 µM -1.05439484770739 0.153653180587473 no 2834 0.145851090089731 964 6465167 SGTC_964 1287-0107 19.4 µM -1.05467106487294 0.15359159127577 no 2835 0.145787894850024 943 51516812 YPR165W RHO1 SGTC_2287 7945887 168.79 µM -1.05974006349702 0.152464238076396 no 2836 0.14463143547059 918 1245853 SGTC_3271 9137798 49.47 µM -1.06064899041831 0.152262673393776 no 2837 0.144424724828736 881 6498326 SGTC_2687 chenodiol 100 µM -1.0623692795489 0.151881664575812 no 2838 0.144034037208493 927 5702181 A cholesterol synthesis inhibitor. SGTC_2273 7815444 169.05 µM -1.06253531244364 0.151844925235339 no 2839 0.143996367926686 961 2824616 SGTC_655 k060-0012 42 µM -1.0635847721405 0.151612840062724 no 2840 0.143758421896912 960 5994525 SGTC_533 1222-0222 6.71 µM -1.06926017951201 0.150361826349552 no 2841 0.142476224212207 958 3982874 SGTC_2709 st078560 56 µM -1.06973044253883 0.15025847708144 no 2842 0.142370329689738 952 17250903 SGTC_1246 0422-0085 105 µM -1.07014738304642 0.150166886056847 no 2843 0.142276486952487 940 264295 SGTC_1878 temozolomide 1 mM -1.07276543410599 0.149592618700396 no 2844 0.141688186647152 919 5394 DNA alkylating agent. SGTC_342 k048-0088 23.3 µM -1.07389556639824 0.149345178533154 no 2845 0.141434745338761 943 6820570 SGTC_1907 st060210 83.7 µM -1.07731047044735 0.148599153342299 no 2846 0.14067079308576 948 688793 SGTC_673 1082-0474 110 µM -1.07761677687269 0.148532359144057 no 2847 0.140602406032414 943 3098046 SGTC_3072 9116419 49.47 µM -1.07763575558628 0.148528221243195 no 2848 0.140598169520386 949 17170162 SGTC_979 1426-2828 121 µM -1.07846188412127 0.148348176362433 no 2849 0.140413841440045 961 747872 SGTC_3295 9122362 53.5725 µM -1.0799357283576 0.148027332232437 no 2850 0.140085400891485 995 4730473 SGTC_3152 9099253 49.47 µM -1.08030265594656 0.147947527283815 no 2851 0.140003713696585 920 25236131 SGTC_1746 st038117 42 µM -1.08170581486881 0.147642612800827 no 2852 0.139691634263386 940 2898218 SGTC_855 0428-0020 25 µM -1.08325413741981 0.147306642235416 no 2853 0.139347817987389 946 6812414 SGTC_497 capsazepine 133 µM -1.08562915423545 0.146792283783241 no 2854 0.138821547948315 956 2733484 A calcium channel blocker. SGTC_1799 st045822 46.1415 µM -1.08596512788532 0.146719619216994 no 2855 0.13874721037764 910 3674992 SGTC_2639 lactacystin 53 µM -1.08805475550826 0.146268215324594 no 2856 0.138285467889179 924 3870 A proteasome inhibitor. SGTC_107 0358-0022 2.6945 µM -1.09458095325083 0.144864428246211 no 2857 0.136850131880053 986 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_881 0833-0569 170 µM -1.09514352477053 0.144743845069067 no 2858 0.136726881477345 952 5418700 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.09580469180576 0.144602215080063 no 2859 0.136582127409558 967 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.10146907886727 0.143392661321125 no 2860 0.135346277484498 970 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_518 1021-0119 62.6 µM -1.10355596196341 0.142948762461738 no 2861 0.134892901636816 962 1097762 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.10395116237801 0.142864804460442 no 2862 0.134807161717498 949 1377 SGTC_1292 0kpi-0043 232 µM -1.10413405287554 0.142825961733888 no 2863 0.134767495732199 956 3333905 SGTC_2811 7967822 32.47 µM -1.10476321804421 0.142692392633083 no 2864 0.134631101168672 941 2232244 SGTC_740 k014-0057 261 µM -1.10962738120346 0.141662602087786 no 2865 0.133579813607079 959 4012779 SGTC_2093 5331342 194.4 µM -1.11308355393251 0.140933963507833 no 2866 0.132836273131018 950 33839 SGTC_53 0973-0023 39.979 µM -1.11450750125295 0.140634504291208 no 2867 0.132530764098142 949 674768 SGTC_2353 9059630 146.67 µM -1.11708779296528 0.140092964338457 no 2868 0.131978394668825 970 4779114 SGTC_2125 5246583 200 µM -1.11759727267814 0.139986204751299 no 2869 0.131869517066615 963 835267 SGTC_3084 9116877 49.47 µM -1.11786865793725 0.139929359548715 no 2870 0.131811546384131 944 27241325 SGTC_1341 1486-1360 280 µM -1.11832001931227 0.139834850734989 no 2871 0.131715169894581 976 3976547 SGTC_1568 digitonin 820 nM -1.11932453343285 0.139624675165203 no 2872 0.131500856570423 974 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2835 9006588 71.43 µM -1.11953666578028 0.139580317971867 no 2873 0.131455628885672 933 2345538 SGTC_2552 juarezic acid 87.02 µM -1.12179707832043 0.139108257412066 no 2874 0.130974364384375 967 1549512 SGTC_1020 4335-0961 93.3 µM -1.12234924031205 0.138993110213637 no 2875 0.130856988807893 980 669075 SGTC_2780 5215298 71.43 µM -1.12755872401697 0.137909924916999 no 2876 0.129753163400406 976 2834131 SGTC_2985 9022375 71.43 µM -1.12790744746533 0.137837622569198 no 2877 0.129679504151932 976 4939335 SGTC_2466 5983409 37.09 µM -1.12972123107067 0.13746198004215 no 2878 0.129296854076555 976 2879657 SGTC_2960 9079389 5.97 µM -1.1320994870461 0.136970492757574 no 2879 0.128796305261266 965 16457355 SGTC_128 0906-2981 13.371 µM -1.13248746017867 0.136890428806487 no 2880 0.128714776708089 959 6740226 SGTC_1312 1218-2183 165 µM -1.13264164339514 0.136858619719834 no 2881 0.1286823866396 958 6744073 SGTC_56 0957-0365 83.25 µM -1.13271812646514 0.136842842597022 no 2882 0.128666321542845 952 6752360 SGTC_2716 st080858 38.6235 µM -1.13417440460988 0.136542675005906 no 2883 0.128360699092579 951 5296050 SGTC_914 3820-6779 408 µM -1.13734543608626 0.135890621728691 no 2884 0.127696953793105 957 2893481 SGTC_2146 5545642 200 µM -1.1377441417723 0.135808787771638 no 2885 0.12761366775619 962 825326 SGTC_1235 benzylparaben 21.5 µM -1.13864534179994 0.135623941711019 no 2886 0.127425554335792 983 7180 SGTC_1423 4048-0112 5.59 µM -1.13969976406621 0.135407886976082 no 2887 0.127205702749945 956 X1423 SGTC_265 mycophenolic acid 32.932 µM -1.14026408728942 0.135292352171117 no 2888 0.127088147403826 980 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2414 st077232 92.9 µM -1.14187559247054 0.134962798198534 no 2889 0.12675286766452 950 729801 SGTC_2157 5649910 96.377 µM -1.14198869685819 0.134939688966102 no 2890 0.126729359021719 961 2858091 SGTC_3 0833-0587 95.581 µM -1.14444442856945 0.134438608583946 no 2891 0.126219685924424 962 5382644 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.14473033983373 0.134380352883519 no 2892 0.126160439654347 966 1273210 SGTC_880 0833-0487 87.2 µM -1.14608928124283 0.134103699487802 no 2893 0.125879106105004 959 76075 SGTC_70 0141-0289 43.283 µM -1.14619972731214 0.13408123207388 no 2894 0.125856260352915 932 352408 SGTC_1393 3470-5649 58.2 µM -1.14713274058016 0.133891537704614 no 2895 0.125663382100424 951 4108395 SGTC_811 0416-0114 265 µM -1.15031518602106 0.133245890917339 no 2896 0.125007039167121 938 6612453 SGTC_1177 0983-0204 23.6 µM -1.15100031383509 0.133107174567283 no 2897 0.124866053214997 943 766818 SGTC_1659 st012954 42.1 µM -1.15470974006512 0.132357861104235 no 2898 0.124104654780743 975 24207262 SGTC_2905 7799065 20.05 µM -1.15744920385893 0.13180635221424 no 2899 0.123544440595743 937 1296806 SGTC_2848 9016370 25.97 µM -1.15889786982022 0.131515348526911 no 2900 0.123248908658057 931 7894410 SGTC_2824 7998404 51.95 µM -1.16313686210574 0.130666381165929 no 2901 0.122386989125374 979 837851 SGTC_493 zm226600 134 µM -1.16405844354344 0.130482313272795 no 2902 0.122200164026536 964 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2747 doxorubicin 7.63 µM -1.16424015925719 0.130446040283727 no 2903 0.122163349845589 904 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2412 st077135 33.4 µM -1.16452729780378 0.130388737645923 no 2904 0.122105193699075 987 13258915 SGTC_2276 7947513 42.08 µM -1.17103891013184 0.129093924553791 no 2905 0.120791568667269 982 2105100 SGTC_3342 9147791 14.508 µM -1.1737044667137 0.1285664675174 no 2906 0.12025671025962 959 1838168 SGTC_2376 9072922 81.32 µM -1.17472204737815 0.128365504932367 no 2907 0.120052967892812 980 17087968 SGTC_1875 nocodazole 6 µM -1.17490639878818 0.128329120613982 no 2908 0.120016082669769 970 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2558 carylophyllene oxide 100 µM -1.17566698597584 0.12817908385421 no 2909 0.11986398805061 979 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1014 4130-3005 69.3 µM -1.17891638966108 0.127539464494973 no 2910 0.119215735373253 981 743608 SGTC_112 phenothiazine 287.218 µM -1.18089786643468 0.127150517530859 no 2911 0.118821649512409 970 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1294 1000-1494 117 µM -1.18273764544343 0.126790124223901 no 2912 0.118456569822575 966 712797 YDL207W GLE1 SGTC_1843 st055809 45.5 µM -1.18568186803763 0.126214863017049 no 2913 0.117873978864429 974 16413835 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.18585863453028 0.126180383220817 no 2914 0.11783906564513 983 140250 A respiratory chain inhibitor. SGTC_2170 morpholine 200 µM -1.18648550956867 0.126058158884215 no 2915 0.117715310299051 973 121171 Reacts with secondary amines. SGTC_837 0091-0265 12.5 µM -1.18744589509613 0.125871068807917 no 2916 0.117525893004631 974 759367 SGTC_1859 st055998 20 µM -1.18820315679528 0.125723685340368 no 2917 0.11737669014952 983 676301 SGTC_906 1165-0455 526 µM -1.19194190324962 0.12499778949347 no 2918 0.116642013068242 972 3252859 SGTC_3059 1327-0034 3 µM -1.19196124021057 0.124994042754076 no 2919 0.11663822178127 966 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2922 7999257 32.47 µM -1.19243875355155 0.12490154441368 no 2920 0.116544626201912 992 2988377 SGTC_1054 3429-0080 167 µM -1.19247838030721 0.124893870528195 no 2921 0.116536861506051 994 1162877 SGTC_623 k072-0108 16.9 µM -1.19388666735983 0.124621363753479 no 2922 0.116261151772367 972 5382803 SGTC_848 0368-0089 85.6 µM -1.19730934517158 0.123960801100219 no 2923 0.115593001645102 965 762535 SGTC_2586 curcumin 80 µM -1.19841565992915 0.123747811901475 no 2924 0.115377619486103 986 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3188 9110789 49.47 µM -1.19857194038227 0.123717745244517 no 2925 0.115347217135061 983 849217 SGTC_2085 5307070 144.047 µM -1.20385123712211 0.122705069572868 no 2926 0.114323540965133 988 2840351 SGTC_1602 st001878 87.6 µM -1.20529169504748 0.122429773143948 no 2927 0.114045357277304 974 595405 YLR310C CDC25 SGTC_2089 5281248 129.67 µM -1.20589748870502 0.122314125069061 no 2928 0.113928509534621 970 2737878 SGTC_2254 7938975 95.19 µM -1.2065559279339 0.12218851376363 no 2929 0.113801604091245 983 2969277 SGTC_3160 9100216 49.47 µM -1.20877375663314 0.121766082102101 no 2930 0.113374888252802 978 17191039 SGTC_1527 coumarin 137 µM -1.20902348926922 0.121718579676638 no 2931 0.113326910644055 994 323 A hepatotoxic, DNA x-linker. SGTC_3339 9145883 14.936 µM -1.21031218974348 0.121473658904812 no 2932 0.113079560984031 934 2030670 SGTC_3233 9132340 49.47 µM -1.21383266681831 0.120806349988705 no 2933 0.11240581462688 998 17682950 SGTC_3073 9114972 49.47 µM -1.21834772059326 0.119954300586392 no 2934 0.111545931423496 964 41905075 SGTC_1794 st048918 76.9 µM -1.21849700561905 0.119926201089854 no 2935 0.111517580989368 903 672303 SGTC_1716 st033144 30.6155 µM -1.2189753916254 0.119836187110861 no 2936 0.111426766353392 981 674617 SGTC_3085 9117376 49.47 µM -1.22091168430523 0.119472337403274 no 2937 0.111059730014515 958 16480349 SGTC_882 0843-0131 351 µM -1.22136513972092 0.119387241127945 no 2938 0.110973899987243 965 5425421 SGTC_1683 st010134 710 nM -1.2214464359082 0.119371989458563 no 2939 0.110958517271323 995 3818134 SGTC_3305 9127027 53.8275 µM -1.22163381642693 0.119336840946787 no 2940 0.110923067289634 970 41905295 SGTC_1700 st030840 7.9285 µM -1.22582021037322 0.118553468154956 no 2941 0.110133169989287 984 5499307 SGTC_2059 5238311 157 µM -1.22670827509503 0.118387758625723 no 2942 0.109966128184009 974 703021 SGTC_1652 st011932 78 µM -1.22896375102498 0.117967631501694 no 2943 0.109542698602863 966 1551076 SGTC_2024 5144227 134 µM -1.23054402898568 0.117673902451996 no 2944 0.10924672500908 977 3475211 SGTC_2655 perillic acid 100 µM -1.23110298147211 0.117570133001028 no 2945 0.109142175294583 992 5702197 An apoptosis inducer. SGTC_161 4065-0411 162.148 µM -1.23500870876489 0.116846842914687 no 2946 0.108413631506891 983 1906281 YLR208W SEC13 SGTC_2990 9074105 71.4286 µM -1.23630276720412 0.116607897144214 no 2947 0.108173021453367 985 6502001 SGTC_479 n-linoleoylglycine 10 µM -1.24045527047394 0.115843484832683 no 2948 0.107403524355417 996 6433346 An anti-infammatory. SGTC_2698 st077697 67.5 µM -1.24065390333741 0.115807008949496 no 2949 0.107366814992614 987 3154499 SGTC_2634 4'-methoxyflavone 100 µM -1.24089878190841 0.115762051977163 no 2950 0.107321571404498 984 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1698 5-fluorocytosine 1.055 µM -1.24240994223978 0.115484894058089 no 2951 0.107042674608381 974 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_259 usnic acid 108.925 µM -1.24592414336665 0.114842187770951 no 2952 0.10639612273222 1014 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_928 2764-0428 58.7 µM -1.24607758059148 0.114814183986981 no 2953 0.106367957342258 993 662578 SGTC_1692 fluoroquinolonic acid 71 µM -1.24623070385753 0.114786242346933 no 2954 0.106339854951536 981 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_312 4092-0653 6.84 µM -1.24644387537272 0.114747351273628 no 2955 0.10630074096068 956 1148278 SGTC_697 0508-1955 564 µM -1.25036247600715 0.114034110252109 no 2956 0.105583582753642 984 6243113 SGTC_2614 arthonioic acid 13.39 µM -1.25681331770545 0.112866854754414 no 2957 0.104410621229065 998 6710684 SGTC_886 0866-0150 153 µM -1.25722529422348 0.112792599977536 no 2958 0.104336033272371 988 271463 SGTC_2753 fluvastatin 17.09 µM -1.2616565123779 0.111996120344779 no 2959 0.103536205791421 995 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1087 pterostilbene 9.05 µM -1.26414606617931 0.111550409183531 no 2960 0.103088802429053 999 5281727 Similar to reservatol, lowers cholesterol. SGTC_186 3455-3465 67.277 µM -1.2655422923855 0.111300995478557 no 2961 0.102838498867969 978 755278 SGTC_699 0375-0592 111 µM -1.26601092677232 0.111217370915317 no 2962 0.102754585144869 961 762578 SGTC_180 1486-1293 102.781 µM -1.26948426683834 0.110598979437842 no 2963 0.102134199214679 969 4140536 SGTC_288 1315-0019 35.1 µM -1.26989278460821 0.110526409462811 no 2964 0.10206141184778 972 6811474 SGTC_281 1672-3440 14.9 µM -1.27144872732644 0.110250321054062 no 2965 0.101784528487818 988 6833000 SGTC_3014 9081533 49.47 µM -1.27156179427917 0.11023027760799 no 2966 0.101764429312238 998 21367265 SGTC_2415 st077333 57.7 µM -1.27293739141879 0.109986633977508 no 2967 0.101520129746301 956 2766255 SGTC_2138 5575593 77.673 µM -1.27363890439489 0.109862531969663 no 2968 0.101395708927157 986 762213 SGTC_3274 9138298 49.47 µM -1.275214057923 0.109584243753531 no 2969 0.101116743424424 998 17015756 SGTC_2035 5154463 94.595 µM -1.28734909845967 0.107457260327851 no 2970 0.0989863187397609 995 2769623 SGTC_2475 5812728 15.03 µM -1.29031607454282 0.10694177738442 no 2971 0.0984704689847794 982 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1946 st076057 65.1 µM -1.29155276676808 0.10672744183455 no 2972 0.0982560351551726 985 953009 SGTC_3206 9114350 49.47 µM -1.29445637710606 0.106225425563716 no 2973 0.0977539139791341 982 17087243 SGTC_3231 9132313 49.47 µM -1.29766373853599 0.105672877704741 no 2974 0.0972014546517477 990 4905967 SGTC_2117 5521686 200 µM -1.29797727402307 0.105618975116161 no 2975 0.0971475721928844 1005 803312 SGTC_1330 1469-0054 61.8 µM -1.29803640870887 0.105608810991372 no 2976 0.0971374120933445 990 7102664 SGTC_682 0kpi-0099 17 µM -1.29935698225001 0.10538201381279 no 2977 0.0969107236937807 982 1714895 YML126C ERG13 SGTC_2518 prenyletin 46.28 µM -1.30310284541556 0.104740611500586 no 2978 0.0962698261654582 980 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2893 9048488 25.97 µM -1.30615815520065 0.104219549448532 no 2979 0.0957493897928207 1010 6467338 SGTC_961 1252-1571 372 µM -1.3083342856801 0.103849572822115 no 2980 0.0953799754717781 1001 6813498 SGTC_75 0159-0059 199.013 µM -1.30902811551303 0.103731811298953 no 2981 0.0952624135755097 975 5377270 SGTC_1142 3253-1408 9.78 µM -1.3093747740982 0.103673010350386 no 2982 0.095203716045368 1005 256655 SGTC_2048 5246248 200 µM -1.31267307287515 0.10311475542101 no 2983 0.0946465674284745 976 677046 SGTC_2350 9023895 38.85 µM -1.312747108162 0.103102249649413 no 2984 0.0946340890252888 963 2997209 SGTC_2346 9031566 143.75 µM -1.31442056890061 0.102819868534753 no 2985 0.0943523561529601 997 4771086 SGTC_2778 tioconazole 65.09 nM -1.31478245792547 0.102758877063992 no 2986 0.0942915123176371 972 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_10 0279-0212 42.575 µM -1.3152655619465 0.102677497437893 no 2987 0.0942103339019271 1014 39851 YBR002C RER2 SGTC_3137 9097352 49.47 µM -1.31560007077525 0.102621176356599 no 2988 0.0941541549033581 971 44120435 SGTC_724 3910-0327 137 µM -1.31606607840081 0.1025427523277 no 2989 0.0940759325753523 1003 2885483 SGTC_1632 st005650 90 µM -1.31856856737033 0.102122355723434 no 2990 0.0936566939382265 987 2759605 SGTC_1815 st051655 58.2 µM -1.32053019342601 0.101793697164209 no 2991 0.0933290310400243 992 5984156 SGTC_1450 4112-4260 37.6 µM -1.32237487752431 0.101485334627573 no 2992 0.0930216750992364 983 1633175 SGTC_747 3448-8087 38.7 µM -1.32430670084984 0.101163135569832 no 2993 0.0927006029937393 1018 5168703 SGTC_3032 9089427 49.47 µM -1.32529493577624 0.100998601358593 no 2994 0.0925366740043278 944 17173707 SGTC_1884 5633444 25 µM -1.32546198046975 0.100970808868729 no 2995 0.0925089857347812 983 5724239 SGTC_309 k408-0051 1.48 µM -1.32654241756464 0.100791183012551 no 2996 0.0923300473471308 969 3640463 SGTC_1922 5578187 25 µM -1.33041176379966 0.100149804479925 no 2997 0.091691320372114 948 1350412 SGTC_199 4063-0024 41.6 µM -1.3340026467756 0.0995572540691278 no 2998 0.0911014945540517 1014 306215 SGTC_1248 0469-0687 58.6 µM -1.33726988678323 0.0990203394936174 no 2999 0.0905672783839148 991 4017482 SGTC_2253 7938677 135.83 µM -1.34183489363306 0.0982737108680237 no 3000 0.0898247677836269 1015 2301972 SGTC_1261 0712-0010 12.7 µM -1.3430147078173 0.0980814189177056 no 3001 0.0896336057189199 997 2840123 SGTC_1058 3448-5425 97.3 µM -1.34317946876753 0.0980545873157869 no 3002 0.0896069340420671 1004 7279705 SGTC_426 0988-0037 14.6 µM -1.34438006674675 0.0978592302575592 no 3003 0.0894127581301336 1006 5383008 SGTC_1760 st045453 10.4495 µM -1.34842519702579 0.0972031209615732 no 3004 0.0887608321462817 1005 3323419 YIL048W NEO1 SGTC_3125 9127534 49.47 µM -1.35149763433926 0.0967069410896167 no 3005 0.0882680385994994 991 1639235 SGTC_2979 9012552 45.46 µM -1.35165971854314 0.0966808172304234 no 3006 0.0882420983710509 1014 17100905 SGTC_1831 st055328 12 µM -1.35176047062751 0.0966645811645207 no 3007 0.0882259767020719 988 1103068 SGTC_2557 derrustone 83.84 µM -1.35453795330775 0.0962177817592003 no 3008 0.0877824067020503 999 629853 An antioxidant. SGTC_1714 st033236 13.627 µM -1.35462714061763 0.0962034598516787 no 3009 0.0877681909124238 999 2916566 SGTC_827 3253-0474 693 µM -1.35589894134719 0.0959994015791106 no 3010 0.0875656622052072 1004 5402065 SGTC_627 1391-0720 175 µM -1.35596448286258 0.0959888941845225 no 3011 0.0875552344624458 1010 997839 SGTC_1007 4101-0031 70 µM -1.3575962567428 0.0957275662753097 no 3012 0.0872959157004437 1023 1146276 SGTC_2784 7567673 72.73 µM -1.35785037331631 0.0956869167599407 no 3013 0.0872555835760993 973 3471247 SGTC_1088 bifonazole 369 nM -1.35866943121159 0.0955559833823162 no 3014 0.0871256814512754 998 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2295 7971645 200 µM -1.36071768995368 0.0952291290125888 no 3015 0.0868014610151355 1018 2978226 YKL099C UTP11 SGTC_1396 3511-0007 98.6 µM -1.36452019498277 0.0946245219181724 no 3016 0.0862019513247432 995 X1396 SGTC_3142 9086498 49.47 µM -1.36927290305219 0.0938728148092159 no 3017 0.0854569924235241 960 25236367 SGTC_2813 7971799 71.43 µM -1.37086860875236 0.0936214226298205 no 3018 0.0852079592824279 1005 2234054 SGTC_1211 1056-0033 32.3 µM -1.37465146142535 0.0930274476313345 no 3019 0.0846197630525102 979 6741922 SGTC_473 2-arachidonoylglycerol 10 µM -1.37606676900936 0.0928059367543535 no 3020 0.0844004813198355 977 5282280 An endocannabinoid. SGTC_185 k048-0037 25.491 µM -1.37692186386721 0.092672294343941 no 3021 0.0842682033421188 1006 6827589 SGTC_1641 st009299 47.1 µM -1.3790277430137 0.0923437744076983 no 3022 0.0839431001457776 996 4046054 SGTC_553 k007-0256 45.7 µM -1.37982591358635 0.0922194842377231 no 3023 0.0838201259395099 1024 6287000 SGTC_559 1550-0661 158 µM -1.38144135957968 0.0919683079213496 no 3024 0.0835716481904572 1003 5830875 SGTC_2683 piperine 63.03 µM -1.38169755950294 0.09192851947181 no 3025 0.0835322920317563 1012 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2456 5770359 74.46 µM -1.38184435186607 0.0919057280186034 no 3026 0.0835097487955798 1007 3118787 SGTC_1990 st072050 59.8 µM -1.38289478327203 0.0917427567780191 no 3027 0.0833485650615279 1011 17233948 SGTC_359 0081-0058 15.9 µM -1.39073330505627 0.0905333881774759 no 3028 0.08215315711794 1006 3494159 SGTC_1369 1866-0067 208 µM -1.39301298714331 0.0901838981784416 no 3029 0.0818079317241456 989 3531355 SGTC_2421 5690543 90.72 µM -1.39416771028197 0.0900072545053992 no 3030 0.0816334830832935 1009 3397993 SGTC_2522 biochanin a 4.94 µM -1.39468650701602 0.0899279753734731 no 3031 0.0815551977591785 1007 5280373 A possible chelator. SGTC_883 0850-0245 24.6 µM -1.39487887396801 0.0898985923034634 no 3032 0.0815261843865828 998 6823229 YPR165W RHO1 SGTC_1018 4259-0013 28.1 µM -1.39590657267542 0.0897417374458666 no 3033 0.0813713155722828 1009 6801262 SGTC_2852 9023854 51.95 µM -1.39664467937553 0.0896292078278029 no 3034 0.0812602237518261 1013 19798528 SGTC_771 0250-0039 27.3 µM -1.39854301002176 0.0893402757798183 no 3035 0.0809750332158239 1013 3005115 SGTC_3256 9138902 49.47 µM -1.40068545528291 0.0890150216335369 no 3036 0.0806540769882417 1037 17228773 SGTC_1472 k841-0093 193 µM -1.4008675589095 0.088987416367371 no 3037 0.0806268407068639 1018 X1472 SGTC_549 1661-1316 519 µM -1.40392207851291 0.0885253282345339 no 3038 0.08017102715939 1012 2857282 SGTC_378 3970-0959 8.33 µM -1.40608500998532 0.0881992023531449 no 3039 0.0798494415077688 1029 6615653 SGTC_1514 1189-1591 158 µM -1.40638528439563 0.0881539979919743 no 3040 0.0798048737987624 1017 767698 YMR146C TIF34 SGTC_2872 9044037 25.97 µM -1.40749470072106 0.0879871323560776 no 3041 0.0796403737661008 1024 6465195 SGTC_2182 6325192 200 µM -1.40921930625107 0.0877282048540977 no 3042 0.0793851653602798 987 736248 SGTC_2026 5148700 152 µM -1.41305415457752 0.0871544893208126 no 3043 0.0788199008386494 1017 79838 SGTC_1657 st012939 43.4 µM -1.41355006686089 0.0870805030280751 no 3044 0.0787470255859696 1000 24207257 SGTC_2649 anisomycin 9.56 µM -1.41502596104434 0.0868605885315921 no 3045 0.0785304422113385 1017 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3291 9121177 71.43 µM -1.42385753314433 0.0855533101277854 no 3046 0.0772438585669734 1007 17015612 SGTC_1874 staurosporine 7.6 µM -1.42947029647614 0.0847301816270843 no 3047 0.0764345531962841 994 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1449 4112-4002 201 µM -1.43291451331849 0.0842280256686599 no 3048 0.0759411345666991 1015 2059539 SGTC_1238 0333-0287 48.8 µM -1.43343537009523 0.0841522812358767 no 3049 0.0758667282101838 1005 7226 SGTC_285 1486-1325 46 µM -1.43486148406243 0.0839451534677991 no 3050 0.0756632865626245 1008 22310230 SGTC_1355 1499-0035 1.68 µM -1.43655436170587 0.0836997783609732 no 3051 0.0754223296622 1022 1548538 SGTC_353 1988-1175 58.3 µM -1.43694356864893 0.0836434407976796 no 3052 0.075367014399508 989 2788357 SGTC_1630 st005209 31.3 µM -1.44051146449609 0.0831283162145842 no 3053 0.0748613744249624 995 3367314 SGTC_3198 9112019 49.47 µM -1.4408367077836 0.0830814772480427 no 3054 0.0748154101694875 1038 45595555 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.44324710310317 0.0827349696008609 no 3055 0.0744754374608606 977 88881 An O-methylated flavonoid and antioxidant. SGTC_2123 5259487 200 µM -1.44385770043405 0.082647365739858 no 3056 0.0743895036443695 1015 2173474 SGTC_1654 st012436 41.8 µM -1.44422684385992 0.0825944377204752 no 3057 0.074337588129274 1036 4323132 SGTC_1552 6-methylflavone 10.6 µM -1.44581439144392 0.0823671049055775 no 3058 0.0741146342361417 1016 689013 SGTC_3336 9143619 71.43 µM -1.44800460427571 0.0820542457666765 no 3059 0.0738078814582521 1026 45595730 SGTC_153 4077-0274 519.67 µM -1.44874942507865 0.0819480567100477 no 3060 0.0737037861234201 996 3121976 SGTC_1422 4031-0024 15.5 µM -1.45256019970776 0.0814063745440107 no 3061 0.0731729516721018 1024 782427 SGTC_1100 amiodarone 5.07 µM -1.45343969313237 0.0812817434713234 no 3062 0.0730508562156975 1007 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2394 5221648 200 µM -1.45416800475566 0.0811786450404348 no 3063 0.0729498666010411 1022 788586 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.45501095063363 0.0810594424255688 no 3064 0.0728331149568136 1023 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3001 9076041 71.4286 µM -1.45815237920133 0.0806163702459542 no 3065 0.0723992732277468 1017 16004211 SGTC_1954 st077032 68.9 µM -1.45868547342923 0.0805413636588997 no 3066 0.0723258480576146 1022 698907 SGTC_639 0833-0042 114 µM -1.46052313507036 0.0802832079248166 no 3067 0.0720731770042195 1026 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1973 st070275 50.2 µM -1.47045048951434 0.0788994107072807 no 3068 0.070719892771658 1019 17118334 SGTC_1715 st032160 10.2275 µM -1.47154601096435 0.0787478172242597 no 3069 0.070571756983921 1008 5289825 SGTC_488 nitrendipine 139 µM -1.47617092635387 0.0781102734167944 no 3070 0.0699490061617518 1045 4507 Dihydropyridine L-type calcium channel blocker. SGTC_406 estrone 100 µM -1.47707469962954 0.0779861470299583 no 3071 0.0698278073137415 1010 5870 A steroid. SGTC_1882 5615643 20 µM -1.47851037369967 0.077789275902136 no 3072 0.0696356112664077 968 2253075 SGTC_162 k030-0015 37.8 µM -1.48004247240787 0.0775795985717443 no 3073 0.0694309561927975 1032 1809920 YMR134W ERG29 SGTC_2919 7978188 46.38 µM -1.48013811510533 0.0775665235123171 no 3074 0.0694181957857856 996 2980291 SGTC_1795 st049545 62.3 µM -1.4877749374024 0.07652790552968 no 3075 0.0684051286583489 988 5291882 SGTC_1553 gossypol 38.6 µM -1.4953220187241 0.0755119191867922 no 3076 0.0674152106401968 1003 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1389 3405-0187 19 µM -1.49604814713422 0.0754147125594676 no 3077 0.0673205544351846 1010 799890 SGTC_1735 st034310 56.75 µM -1.49629392223642 0.075381832320899 no 3078 0.0672885391168419 1009 871153 SGTC_2676 harmalol 100 µM -1.49721534362063 0.0752586601627235 no 3079 0.0671686170899483 1012 5459187 A monoamine oxidase inhibitor SGTC_2720 fluspirilene 36.88 µM -1.5001181251375 0.0748716301929696 no 3080 0.0667919033404398 1021 3396 An atypical antipsychotic. SGTC_84 0443-0269 128.823 µM -1.50036563244148 0.0748387002468661 no 3081 0.0667598584189437 998 6150058 SGTC_176 1486-1328 72.834 µM -1.50042197998965 0.0748312049549722 no 3082 0.06675256473027 1006 22310231 SGTC_999 SEC7.066 22.7 µM -1.50196810735635 0.0746257640933695 no 3083 0.066552672789875 1034 740511 YDR170C SEC7 SGTC_2332 7982454 138.89 µM -1.50668142424676 0.0740021406050562 no 3084 0.0659461675926553 1031 2981748 SGTC_1881 5652484 16 µM -1.51463375443681 0.0729589972750422 no 3085 0.0649325895771028 1030 2255129 SGTC_2718 lomofungin 53.02 µM -1.5200338705692 0.0722570811480558 no 3086 0.064251231595724 1026 5351222 A RNA synthesis inhibitor. SGTC_1089 terbinafine 2.25 µM -1.52121032243738 0.0721048527577839 no 3087 0.0641035329443577 1013 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_443 clozapine 122 µM -1.52128498504869 0.072095200002886 no 3088 0.0640941682780448 1044 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1525 8-methoxypsoralen 92.5 µM -1.52281627722848 0.0718974453391727 no 3089 0.0639023382415372 1046 4114 Related to psoralen; DNA damaging agent. SGTC_3064 1327-0027 10 µM -1.52497156554816 0.0716198114494228 no 3090 0.0636330950132287 1006 16000455 YPR107C YTH1 SGTC_941 3237-0776 460 µM -1.52601951166467 0.0714851176043569 no 3091 0.0635025026609997 1027 760008 SGTC_1649 st011737 51.3 µM -1.52711226133589 0.0713448722285594 no 3092 0.0633665492497188 982 1761035 SGTC_732 3970-1727 52.7 µM -1.52766430549972 0.0712741022743809 no 3093 0.0632979533988746 1033 1275699 SGTC_2885 9057732 51.95 µM -1.52942772794792 0.0710483992468879 no 3094 0.0630792214614669 1030 6471414 SGTC_1793 st048256 72.231 µM -1.53229102039345 0.0706830919947733 no 3095 0.0627253180027614 1007 672022 SGTC_2796 7949634 45.45 µM -1.53233304031641 0.0706777417368674 no 3096 0.062720135877523 1009 2971588 SGTC_1390 3413-2614 145 µM -1.53249075158936 0.0706576636578357 no 3097 0.0627006890424883 1041 3421432 SGTC_1111 tnp00062 510.699 nM -1.53527350943401 0.0703041138814713 no 3098 0.0623583291662463 1022 676306 SGTC_1286 0929-0070 131 µM -1.53551813128102 0.0702730998071456 no 3099 0.0623283034313393 1023 1420408 SGTC_1351 1496-0003 46.5 µM -1.53704912477236 0.0700792336545119 no 3100 0.0621406400090842 1036 3891978 SGTC_3107 9121808 49.47 µM -1.54116276385556 0.0695603709992874 no 3101 0.0616385887543843 977 662681 SGTC_2286 7945697 125 µM -1.54172213265657 0.0694900455965285 no 3102 0.0615705656048848 1013 1245733 SGTC_2429 5902844 64.44 µM -1.54777795232114 0.068732192056469 no 3103 0.0608378832527151 1014 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1224 0823-0416 294 µM -1.55863738790269 0.0673891734712857 no 3104 0.0595411143453848 1018 3598164 SGTC_1753 st043925 64 µM -1.56113463260937 0.0670832194139029 no 3105 0.0592459940829697 1041 670181 SGTC_3330 9141424 71.43 µM -1.56256928736717 0.0669079367950601 no 3106 0.0590769684580588 1024 27261020 SGTC_779 1360-0071 233 µM -1.56413077523334 0.0667175609111045 no 3107 0.0588934299755619 1014 7566 SGTC_1976 st070609 63.5 µM -1.57061682195474 0.0659312689608961 no 3108 0.0581358400847177 1024 682556 SGTC_3272 9137413 49.47 µM -1.57199244354747 0.0657654315133727 no 3109 0.0579761518416642 1029 17614870 SGTC_2479 5617353 43.85 µM -1.57216522221644 0.0657446251343287 no 3110 0.057956119321816 1022 2731746 SGTC_46 0329-0187a 2.197 µM -1.57752733318941 0.0651014413439864 no 3111 0.0573371189609976 1031 46494817 SGTC_3100 9120536 49.47 µM -1.57844104430781 0.06499233053298 no 3112 0.0572321611019567 1017 16421196 SGTC_182 3448-4371 550.524 µM -1.58430632562694 0.0642953048327923 no 3113 0.0565620135078182 1025 3491403 SGTC_1259 0671-0132 43 µM -1.58773007585477 0.0638911225113628 no 3114 0.0561736945230505 1022 X1259 SGTC_2567 aureobasidin a 60 nM -1.59313318297551 0.0632572954590859 no 3115 0.0555651583218848 1014 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_478 N-arachidonylglycine 10 µM -1.59381332853366 0.0631778571589775 no 3116 0.0554889256741094 1058 5283389 SGTC_1068 loratadine 26.9 µM -1.59518768178956 0.0630175752541528 no 3117 0.0553351362642992 1045 3957 A H1 histamine antagonist. SGTC_3223 9129970 49.47 µM -1.60177840591147 0.0622533394222536 no 3118 0.0546023099191231 1039 17248386 SGTC_909 3448-9333 149 µM -1.60387907787894 0.0620112785294445 no 3119 0.0543703547017642 1037 3344074 SGTC_2982 9019404 25.97 µM -1.60411346133468 0.0619843160790505 no 3120 0.0543445226011643 1006 22333232 SGTC_2221 6807166 181.081 µM -1.61493982882132 0.060748840024873 no 3121 0.0531618629820493 1041 674925 SGTC_1116 jasmonic acid  1.58368 µM -1.62094430432309 0.0600719756837996 no 3122 0.0525147919865738 1032 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1661 st013063 9.66 µM -1.62146464310821 0.0600135987924818 no 3123 0.052459013423478 1036 721395 SGTC_1613 st002381 52.1 µM -1.62639244520251 0.0594629481037725 no 3124 0.0519330984722593 1025 551167 SGTC_129 0088-0017 176.636 µM -1.62926920965288 0.059143323488253 no 3125 0.051628020643235 1033 182446 SGTC_1498 4478-3555 97.6 µM -1.6384878361532 0.0581281539485552 no 3126 0.0506599847168188 1039 3437919 SGTC_2411 st077133 39.94 µM -1.64117005586555 0.0578353695123431 no 3127 0.050381059845093 1035 1403142 YNL221C POP1 SGTC_1955 wogonin 32.4 µM -1.64431074370656 0.0574940147607625 no 3128 0.0500560156145892 1021 5281703 A flavanone. SGTC_2798 7813637 45.45 µM -1.64445017172922 0.0574788974422592 no 3129 0.050041624421552 1035 956368 SGTC_468 gf-109203x 121 µM -1.65472893615696 0.056373021384486 no 3130 0.0489897473490178 1064 2396 A protein kinase C inhibitor. SGTC_3293 9120939 62.045 µM -1.65772371251053 0.0560539929095575 no 3131 0.0486866226908605 1040 934087 SGTC_2275 7947463 200 µM -1.66019588185884 0.0557917112060544 no 3132 0.0484375264250393 1005 1225414 SGTC_605 1315-0399 119 µM -1.6649729508632 0.0552876383311032 no 3133 0.0479590762242385 1047 24020461 SGTC_1135 dihydrocapsaicin 536.708 nM -1.66693782220206 0.0550813533609247 no 3134 0.0477633845904729 1032 107982 A Capsaicinoid. SGTC_1921 5740136 50 µM -1.6672515728696 0.0550484701503927 no 3135 0.0477321958319263 1028 1774243 SGTC_287 k060-0039 29.6 µM -1.66834112711204 0.0549343978756604 no 3136 0.0476240140301043 1041 5861974 SGTC_3109 9122853 49.47 µM -1.66872392906625 0.054894364309927 no 3137 0.0475860522888422 1062 1234709 SGTC_3028 9087778 49.47 µM -1.66969858554567 0.0547925384731394 no 3138 0.0474895068750533 1036 17217395 SGTC_102 gallobenzophenone 83.616 µM -1.67372391155142 0.0543735791086849 no 3139 0.0470924360716332 1015 70837 SGTC_2460 5552655 174.22 µM -1.67661704502915 0.0540740276154729 no 3140 0.0468086957461114 1042 5401989 SGTC_2719 novobiocin 32.65 µM -1.67682674526717 0.0540523663794348 no 3141 0.0467881830834495 1054 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2428 5615643 7.78 µM -1.67928412797046 0.0537990396254049 no 3142 0.0465483414079356 1026 2253075 SGTC_1883 5-benzylidenerhodanine 20 µM -1.6794415305755 0.0537828453940859 no 3143 0.0465330125284272 1023 1273210 SGTC_643 k048-0106 28.4 µM -1.69959464699572 0.0517411021628191 no 3144 0.0446035989718888 1038 6763920 SGTC_2094 5332512 191.667 µM -1.70163178093252 0.0515381925868994 no 3145 0.0444122080001588 1046 755774 SGTC_1811 st050069 61.5 µM -1.70225526795909 0.0514762165255925 no 3146 0.0443537631501441 1048 3877702 SGTC_570 0987-0065 62.6 µM -1.70269813546942 0.0514322304768731 no 3147 0.0443122869955532 1015 3104428 SGTC_2458 5808907 16.39 µM -1.70412352375299 0.0512908623803968 no 3148 0.0441790063614822 1046 2731747 SGTC_2635 hydroquinidine 100 µM -1.7044211180482 0.0512613864199967 no 3149 0.0441512206882807 1045 442912 An experimental heart treatment. SGTC_29 0299-0004 12.984 µM -1.70807621336377 0.0509004566759333 no 3150 0.0438111009503207 1041 16871 A napthoquinone isolated from Swertia calycina. SGTC_3221 9128209 49.47 µM -1.70896532465695 0.0508129662263774 no 3151 0.0437286863723986 1044 16460723 SGTC_1640 st009078 66.4 µM -1.70960143907143 0.0507504447209748 no 3152 0.0436697996815341 1035 690618 SGTC_519 k048-0011 62.8 µM -1.71393500837672 0.0503261417364303 no 3153 0.0432703313257146 1032 6836379 SGTC_2462 5162487 171.77 µM -1.71485434564161 0.050236493254863 no 3154 0.0431859673884235 1061 2259986 SGTC_2180 6301957 200 µM -1.71832942803745 0.0498987726207616 no 3155 0.0428682723061231 1036 845462 SGTC_571 k831-0106 44.2 µM -1.71859732891307 0.0498728124390687 no 3156 0.0428438591950739 1032 4783639 SGTC_567 1080-0542 68.4 µM -1.71861855520974 0.0498707560250857 no 3157 0.0428419253782877 1034 5950415 SGTC_1967 st070177 51.4 µM -1.72164626864931 0.0495781218381521 no 3158 0.0425668081116448 1060 5729214 SGTC_1805 st050013 60.3 µM -1.72217133806085 0.0495275126038674 no 3159 0.0425192426457207 1037 4037144 SGTC_1373 2887-0003 58.5 µM -1.72410710122169 0.0493412886466542 no 3160 0.0423442551855485 1038 776948 SGTC_1825 st052143 62.6 µM -1.72928519134938 0.048845893838051 no 3161 0.0418790328390886 1057 674173 SGTC_1207 2099-0101 141 µM -1.72988789836428 0.0487884912100062 no 3162 0.0418251529179222 1044 5837381 SGTC_111 0083-0039 52.457 µM -1.74015557054825 0.047818842433762 no 3163 0.0409158523444824 1041 759313 SGTC_2110 5483698 200 µM -1.74127805872629 0.0477137801564181 no 3164 0.0408174251486054 1042 2848765 YHR062C RPP1 SGTC_1344 1488-0097 29.1 µM -1.7423562012923 0.0476130426449745 no 3165 0.0407230674276765 1055 747966 SGTC_1720 st037298 9.481 µM -1.74244046408782 0.0476051766348106 no 3166 0.0407157003145322 1042 597396 SGTC_788 1182-0090 188 µM -1.75240807938969 0.0466820104192952 no 3167 0.039851831586723 1047 5715185 SGTC_1902 st060212 70.5 µM -1.75668421835967 0.0462903975049648 no 3168 0.0394858244883496 1032 688944 SGTC_1348 1493-0373 93.8 µM -1.75714817491675 0.0462480670145341 no 3169 0.0394462780693945 1052 3010129 SGTC_3162 9099653 49.47 µM -1.76047732962995 0.0459452324641726 no 3170 0.039163454012947 1047 25237511 SGTC_1969 st069479 40.1 µM -1.76120176541952 0.0458795461284923 no 3171 0.0391021296815629 1048 3895485 SGTC_2492 derrusnin 100 µM -1.7653499418091 0.0455048728666665 no 3172 0.0387524854334938 1053 1715307 Part of coumarin class of compounds. SGTC_1208 2323-2347 50.3 µM -1.79226339287561 0.043133377707919 no 3173 0.0365453921360415 1047 5412760 SGTC_392 N-ethylmaleimide 8.33 µM -1.79386418867867 0.0429955286820702 no 3174 0.0364174242955885 1043 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_722 3534-0461 190 µM -1.79587089062346 0.0428232289432196 no 3175 0.0362575264850532 1045 658262 SGTC_132 0417-1715 25.805 µM -1.79604934580439 0.0428079334570035 no 3176 0.0362433347099441 1057 6769098 SGTC_2396 5342950 42.78 µM -1.79729018699501 0.0427017023696023 no 3177 0.03614478162927 1015 1886677 SGTC_701 4424-0219 185 µM -1.79780419705671 0.0426577593320725 no 3178 0.0361040210109452 1054 2911779 SGTC_2549 cedrol 20.94 µM -1.79924813859102 0.0425345114579775 no 3179 0.0359897188698711 1041 6708665 A sedative which affects the nervous system. SGTC_1509 1326-1131 80 µM -1.79995258576062 0.0424744878474172 no 3180 0.0359340626343734 1032 768313 SGTC_1738 st035555 74 µM -1.80425773592475 0.0421091473711073 no 3181 0.035595456023132 1044 5331140 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.80630759575295 0.0419360896451647 no 3182 0.0354351530184063 1060 75037 A free radical scavenger. SGTC_2130 NSC 7 2.4545 µM -1.81431065361066 0.0412659429912032 no 3183 0.0348149561481043 1059 21448 SGTC_832 4083-0019 164 µM -1.81577411702806 0.041144341920295 no 3184 0.0347025146184129 1053 1990758 SGTC_3245 9134821 49.47 µM -1.8193437861598 0.040848951902157 no 3185 0.0344294985618078 1053 17014901 SGTC_766 1391-0721 126 µM -1.82168449174797 0.040656194246569 no 3186 0.034251436201748 1060 1020919 YIL115C NUP159 SGTC_31 0508-1974 57.237 µM -1.82233658372423 0.0406026259931922 no 3187 0.0342019652369394 1043 6810525 SGTC_1562 morin hydrate 59.1 µM -1.82293023224276 0.0405539086020989 no 3188 0.0341569791773209 1043 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_321 4534-3890 65.3 µM -1.82487434726925 0.0403946980819434 no 3189 0.0340099965783856 1044 699746 SGTC_2242 6630449 61.2675 µM -1.82660909636993 0.0402530621314025 no 3190 0.0338792823584048 1054 691249 YDR170C SEC7 SGTC_1043 0916-0009 19.3 µM -1.82808841218356 0.0401326002695742 no 3191 0.033768141886154 1058 3101130 SGTC_3168 9103419 49.47 µM -1.83503845840442 0.0395705669952254 no 3192 0.0332499956632446 1062 16649256 SGTC_617 3770-0098 35 µM -1.83559326564309 0.0395259783771344 no 3193 0.0332089169493932 1049 5962639 SGTC_2143 5623677 140.463 µM -1.83858507240199 0.039286237435344 no 3194 0.032988119271815 1036 5375313 SGTC_1495 4469-0029 237 µM -1.8428865181729 0.0389436268430756 no 3195 0.0326727905534852 1048 793680 SGTC_1968 st069590 43.6 µM -1.84493905877436 0.0387810013817881 no 3196 0.0325232020334384 1043 6384066 SGTC_1482 3346-2049 8.48 µM -1.84764777697314 0.0385672332829952 no 3197 0.0323266566579125 1062 3826804 SGTC_1860 st056228 74.6 µM -1.84892239575369 0.0384669749779252 no 3198 0.0322345096542839 1053 688679 SGTC_1392 3455-1037 33.9 µM -1.85367107514491 0.0380953242197001 no 3199 0.0318931161506522 1045 981132 SGTC_619 1652-1634 108 µM -1.85518680767562 0.0379773153766086 no 3200 0.0317847774463503 1061 5400454 SGTC_1499 4480-0877 67.3 µM -1.86676533751498 0.0370856663462575 no 3201 0.030967182497921 1050 2861909 SGTC_2313 7726885 200 µM -1.872552951803 0.0366464246875204 no 3202 0.0305650716720449 1050 726423 SGTC_3247 9135149 49.47 µM -1.87705709520994 0.0363075424581309 no 3203 0.0302551344821279 1048 8934436 YOR116C RPO31 SGTC_385 1494-0393 12.4 µM -1.88043404293954 0.0360551541942534 no 3204 0.0300244737926269 1063 3090647 SGTC_629 3448-6466 76.7 µM -1.88275667989533 0.0358823989977139 no 3205 0.0298666751314875 1062 573744 SGTC_1085 doxorubicin 7.67 µM -1.88761105457834 0.0355235254342972 no 3206 0.0295390924644544 1040 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1420 4'-methoxyflavone 42 µM -1.89207951708005 0.0351957876651611 no 3207 0.0292401934795719 1051 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3068 9116768 49.47 µM -1.89524681004659 0.0349649892603526 no 3208 0.0290298556379942 1053 41904888 SGTC_751 0833-0568 350 µM -1.89645141910722 0.0348775369537677 no 3209 0.0289501890677213 1063 6954252 SGTC_1114 scopoletin 1.73284 µM -1.90372089351394 0.0343535910064524 no 3210 0.0284732719180244 1064 5280460 A coumarin with genotoxic properties. SGTC_913 3487-1245 167 µM -1.90455443598959 0.0342939291297733 no 3211 0.0284190071009389 1039 4016153 SGTC_878 0828-0289 13.7 µM -1.90734258638806 0.0340949822221264 no 3212 0.0282381194417273 1042 745350 YLR208W SEC13 SGTC_2515 chrysin 20.77 µM -1.91886264540158 0.0332830107363713 no 3213 0.0275008595808826 1038 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2970 9090938 41.86 µM -1.92505306921096 0.0328533097542218 no 3214 0.0271113596858905 1044 17217104 SGTC_852 0418-0143 439 µM -1.93654391355963 0.03206781043942 no 3215 0.0264005598101043 1007 5369229 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.93932144599191 0.0318802871274825 no 3216 0.0262311045372343 1052 1241132 A phosphatase inhibitor. SGTC_1820 st053765 18.6 µM -1.94210741201746 0.0316931052366529 no 3217 0.0260620492045742 1055 3690829 SGTC_3060 1327-0027 12.5 µM -1.94731535645497 0.0313456323970066 no 3218 0.0257484693830391 1035 16000455 YPR107C YTH1 SGTC_1939 st074455 53.6 µM -1.95286671483622 0.0309787217478766 no 3219 0.0254176953467749 1064 1644229 SGTC_449 xestospongin c 11.1929 µM -1.95660469380473 0.0307336721802244 no 3220 0.0251969813714757 1076 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_104 0074-0074 590.992 µM -1.95666865808722 0.0307294929002603 no 3221 0.0251932185360795 1050 3943124 SGTC_1579 chlormadinone acetate 49.4 µM -1.96420265786388 0.0302405200761661 no 3222 0.0247532973600838 1059 45114258 A steroidal progestin. SGTC_1910 st062352 60.4 µM -1.96832490047961 0.0299757185877932 no 3223 0.0245153333390822 1057 2245730 SGTC_943 3253-1379 105 µM -1.97022130391498 0.0298545462332522 no 3224 0.0244065064914733 1045 668464 SGTC_1034 k072-0165 12.7 µM -1.98181465196063 0.0291225833372746 no 3225 0.0237499944883825 1067 5835461 SGTC_2743 auranofin 4.32 µM -1.98621383731786 0.0288487649230354 no 3226 0.0235047925204746 1063 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2355 9061122 103.12 µM -1.99738976908447 0.028162753597248 no 3227 0.0228914291753814 1076 5302957 SGTC_2490 carminic acid 95.39 µM -2.00032091465167 0.0279850964831727 no 3228 0.0227328110154004 1057 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2218 6965428 192.983 µM -2.00074351898737 0.0279595595314855 no 3229 0.0227100184756481 1055 675684 SGTC_133 0724-0033 378.92 µM -2.00272207951068 0.0278402579488668 no 3230 0.0226035637579997 1071 280309 SGTC_2691 st077356 60.2 µM -2.00962096039125 0.027427587688603 no 3231 0.0222356605552364 1068 2839272 SGTC_1141 3253-0389 52.6 µM -2.01165792858161 0.0273067222356983 no 3232 0.022128004194943 1067 5402031 SGTC_65 0798-0905 34.986 µM -2.01208000674847 0.0272817334677918 no 3233 0.0221057519334338 1071 3602145 SGTC_141 0443-0274 32.331 µM -2.01368313823157 0.0271869952199117 no 3234 0.0220214057253408 941 1627241 SGTC_418 lividomycin a 100 µM -2.01733189570198 0.0269723921265505 no 3235 0.021830444602958 1068 72394 An antibiotic. SGTC_3024 9090631 49.47 µM -2.02490733411624 0.0265313530712924 no 3236 0.0214384401891185 1055 25236383 SGTC_109 0132-0036 33.701 µM -2.03139514274457 0.0261584405200939 no 3237 0.0211074633821798 1044 67274 A color developer. SGTC_3106 9121286 49.47 µM -2.0324303151447 0.026099347259315 no 3238 0.021055055856573 1053 15943471 SGTC_2219 9098279 200 µM -2.04421923115831 0.0254342124538675 no 3239 0.0204659470822697 1070 902349 SGTC_1834 st055981 52.8 µM -2.047203794129 0.0252680928486352 no 3240 0.0203190395349628 1063 471719 YDL150W RPC53 SGTC_863 0466-0191 129 µM -2.05193461271385 0.0250066403693774 no 3241 0.0200880087382817 1077 765160 YPR165W RHO1 SGTC_1751 st044839 27.194 µM -2.05331175510622 0.0249309590632347 no 3242 0.0200211757594227 1063 5291326 SGTC_44 0929-0055 61.211 µM -2.05719625158255 0.0247185195255312 no 3243 0.0198336759869403 1039 1379590 SGTC_1215 3852-0577 11.2 µM -2.06681826145 0.0241988322307062 no 3244 0.0193756410347528 1063 2884876 SGTC_3318 9139014 38.6185 µM -2.07463811551379 0.023783268000504 no 3245 0.0190100433889603 1064 16643984 SGTC_2871 9038510 12.99 µM -2.07686273494298 0.0236661488849305 no 3246 0.0189071150125109 1069 4945164 SGTC_1192 1488-0095 21.4 µM -2.08622501935339 0.0231785567170611 no 3247 0.0184791224649558 1070 915875 SGTC_752 1896-0090 130 µM -2.09716672470297 0.0226194527912377 no 3248 0.0179894094975439 1076 772567 SGTC_1540 guanosine 70.6 µM -2.10478849068548 0.0222367466806728 no 3249 0.0176548617359027 1069 6802 Guanosine is a purine nucleoside SGTC_2217 6934799 96.0675 µM -2.1108194424107 0.0219378041211718 no 3250 0.0173939171650037 1073 675606 SGTC_2493 resveratrol 26.09 µM -2.14555064847981 0.0202815242984444 no 3251 0.0159544232178394 1069 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2075 5212009 200 µM -2.15129210824344 0.0200181992664893 no 3252 0.015726575387642 1073 780898 SGTC_2817 7995342 71.43 µM -2.15329248435238 0.0199271383251689 no 3253 0.015647849542335 1062 18879975 SGTC_1234 0326-0494 15.5 µM -2.1547249505647 0.0198621458957227 no 3254 0.0155916820667939 1080 1547813 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.15554053681537 0.01982522235991 no 3255 0.015559780019795 1068 17037758 SGTC_2877 9040724 71.43 µM -2.18091361761297 0.0187052773347833 no 3256 0.0145949031512995 1080 6463895 SGTC_2915 7971052 15.16 µM -2.18264507953163 0.0186308549972564 no 3257 0.0145309786484599 1057 5741558 SGTC_1928 4'-methoxychalcone 40.3 µM -2.19715603761449 0.0180169901678035 no 3258 0.0140046520589445 1065 641818 SGTC_1356 1502-0781 85.8 µM -2.20305232706278 0.0177725292415492 no 3259 0.0137955303653647 1076 567702 SGTC_889 0919-1524 82.7 µM -2.20450032368016 0.0177129297631733 no 3260 0.0137445886066355 1081 3905452 SGTC_276 colchicine 750 µM -2.20650110498787 0.0176308583731456 no 3261 0.0136744664758011 1068 2833 A microtubule depolymerizer. SGTC_2568 diosmetin 100 µM -2.20735156886335 0.0175960710458562 no 3262 0.013644753566986 1075 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1951 sophoraflavanone G 9.2 µM -2.20998194428668 0.0174888488929466 no 3263 0.0135532077091266 1058 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_211 3455-0679 143.504 µM -2.21190535798334 0.0174107981893396 no 3264 0.0134866024856376 1066 748649 SGTC_743 1275-0778 158 µM -2.21733234039831 0.0171921771037939 no 3265 0.0133001947375282 1054 2849257 YMR203W TOM40 SGTC_1410 3909-8106 77.9 µM -2.22141011306783 0.0170294549657883 no 3266 0.0131615983434597 1074 1039210 SGTC_938 3126-1755 342 µM -2.22621879207344 0.0168392595911293 no 3267 0.0129997649130891 1073 1777771 SGTC_1361 1608-0041 5.61 µM -2.23002630078853 0.0166899545111515 no 3268 0.0128728484379162 1078 X1361 SGTC_1758 st042942 75.2445 µM -2.2321672004246 0.0166065012616292 no 3269 0.0128019571688552 1075 669317 SGTC_2605 digitonin 300 nM -2.24065532996788 0.0162791355785329 no 3270 0.0125242048581253 1079 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_603 3794-0023 45.9 µM -2.24929115383485 0.0159517619753026 no 3271 0.0122469891346841 1084 3802260 SGTC_2939 9044578 71.43 µM -2.25298796297141 0.015813355052136 no 3272 0.012129953968143 1074 2653634 SGTC_588 3970-1144 52.9 µM -2.25396520975408 0.015776939931058 no 3273 0.0120991783585826 1076 1888707 SGTC_2772 vinpocetine 57.06 µM -2.27936301439832 0.0148554511846759 no 3274 0.0113227475043871 1073 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1956 st077085 54 µM -2.281210162755 0.0147902759379119 no 3275 0.0112680068367062 1079 24208685 SGTC_212 3807-4682 38.772 µM -2.29209843995614 0.0144110674170632 no 3276 0.0109499817043556 1080 3125501 YBL034C STU1 SGTC_1862 st057513 3.81 µM -2.29710552715516 0.0142395133331026 no 3277 0.0108063752764142 1074 5393163 SGTC_2546 rhodinyl acetate 100 µM -2.30875775483878 0.0138470789270376 no 3278 0.0104785137318132 1067 6708682 SGTC_535 2293-4129 48.2 µM -2.31610983211525 0.0136042975972463 no 3279 0.0102761363040651 1081 396118 YIL048W NEO1 SGTC_3166 9102297 49.47 µM -2.32390911311171 0.0133507728003599 no 3280 0.01006518286817 1079 25237072 SGTC_3110 9122132 49.47 µM -2.33131097540988 0.0131139507896179 no 3281 0.00986848395460549 1085 918317 SGTC_2875 9039966 71.43 µM -2.33269467551168 0.0130700845235052 no 3282 0.00983208792633923 1085 6463691 SGTC_2940 9060638 45.86 µM -2.34335053534533 0.0127365001183314 no 3283 0.00955570896156891 1070 4027022 SGTC_894 0960-0238 55.9 µM -2.34388672280406 0.0127199110774825 no 3284 0.00954198324468909 1076 6741907 YDL195W SEC31 SGTC_625 k213-0058 121 µM -2.36795696803888 0.0119942133670849 no 3285 0.00894330807811626 1074 3655420 SGTC_3063 1327-0034 4 µM -2.38100798194716 0.0116159574993907 no 3286 0.00863266891997077 1067 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_33 0986-0033 35.816 µM -2.38276058887919 0.0115659591577071 no 3287 0.00859168272408651 1080 2848082 SGTC_2520 obtusaquinone 4.71 µM -2.38335689339371 0.0115489904534636 no 3288 0.00857777661117525 1070 5967872 SGTC_3103 9120822 49.47 µM -2.39246321236178 0.0112925304674555 no 3289 0.00836785286595691 1066 17141819 SGTC_2525 harmine 47.85 µM -2.41266624693637 0.0107411659006767 no 3290 0.0079181567378153 1071 5280953 A monoamine oxidase inhibitor SGTC_83 0170-0301 39.027 µM -2.44151992889771 0.00999441222570592 no 3291 0.00731279053505266 1090 3089716 SGTC_400 oxethazaine 37.5 µM -2.45083539693895 0.00976319833719522 no 3292 0.00712625561970527 1084 4621 A local anesthetic. SGTC_2245 6637752 200 µM -2.46537805381837 0.00941158297550073 no 3293 0.00684343777689614 1081 681890 SGTC_2069 5228469 200 µM -2.4880766241712 0.00888489918580236 no 3294 0.00642180288861815 1085 2835210 SGTC_1798 st045719 60.953 µM -2.512572562271 0.00834565785658843 no 3295 0.00599272270229138 1077 3980186 SGTC_672 1441-0018 53.7 µM -2.51470141845347 0.00830018058604029 no 3296 0.00595666151573275 1082 251141 SGTC_994 3910-0338 138 µM -2.52661998941929 0.00804957065014033 no 3297 0.00575830202185353 1085 3479481 SGTC_3193 9111931 49.47 µM -2.53278460451029 0.00792257704910234 no 3298 0.00565802323858993 1077 17087244 SGTC_1660 st012960 28.1 µM -2.54006319500543 0.00777490618272912 no 3299 0.00554162203561353 1079 24207266 SGTC_1821 st053465 65.6 µM -2.54989086761803 0.00757936394953511 no 3300 0.00538783221273755 1090 675086 SGTC_2620 irigenin 100 µM -2.55302011567046 0.00751801662563078 no 3301 0.00533966641552364 1071 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2751 anetholtrithion 17.25 µM -2.55969606689219 0.00738859799991798 no 3302 0.00523818706059548 1087 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_113 0099-0221 2.5 µM -2.56251252335991 0.00733459029485521 no 3303 0.00519589199185471 1077 89219 SGTC_2393 9031399 185.94 µM -2.56391400821677 0.00730784564429421 no 3304 0.00517495916969703 1082 1526623 YDL150W RPC53 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -2.57532917900781 0.00709319192473545 no 3305 0.00500723633209312 1081 6708760 SGTC_2397 5161689 200 µM -2.6171580126129 0.00635342215407888 no 3306 0.00443326430560275 1079 2259942 SGTC_1995 st072814 61.1 µM -2.61975113888993 0.00630989501583693 no 3307 0.00439969774307744 1087 5769371 SGTC_2764 methyldopa 94.69 µM -2.62298018917486 0.00625606269772867 no 3308 0.00435821703767974 1084 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_332 4112-0506 40.9 µM -2.62654940210138 0.00619703298798207 no 3309 0.00431277353484872 1085 2790355 SGTC_887 0885-0007 9.62 µM -2.62993790102328 0.00614144906908251 no 3310 0.00427002331861268 1091 5719458 SGTC_2337 9009472 200 µM -2.65034149375034 0.00581599702439374 no 3311 0.0040205224262036 1076 5742383 SGTC_3189 9110682 49.47 µM -2.65274407306433 0.00577869938087771 no 3312 0.00399201907961457 1081 17122418 SGTC_1790 st045711 43.5 µM -2.65332157345855 0.00576976596620018 no 3313 0.0039851948524747 1078 585119 SGTC_88 0180-0332 8.668 µM -2.66122082119528 0.00564879618429979 no 3314 0.00389289385690363 1082 3101745 SGTC_1321 1326-2144 215 µM -2.677601905541 0.00540508836399307 no 3315 0.00370756460243805 1088 3513030 SGTC_2285 7945142 200 µM -2.70493940684743 0.00501913910923869 no 3316 0.00341584248652172 1080 2970608 SGTC_933 2914-0560 114 µM -2.70809834130985 0.00497616231951989 no 3317 0.00338349837620222 1082 463887 SGTC_564 3555-0129 330 µM -2.73106130088141 0.00467348356737869 no 3318 0.00315653639317067 1084 563260 SGTC_971 1315-0384 26.7 µM -2.76343262879101 0.00427469434012061 no 3319 0.00285984493557217 1093 6769120 SGTC_1895 st058434 18.3 µM -2.77643349088881 0.00412329319019818 no 3320 0.00274794390451744 1092 5393175 SGTC_2193 5925765 200 µM -2.8080722618385 0.00377470430726266 no 3321 0.00249195209999102 1087 877370 SGTC_1887 st057648 70.8 µM -2.81555948583638 0.00369618012981546 no 3322 0.00243461907992882 1088 688672 SGTC_2476 5806916 10.51 µM -2.82585598946198 0.00359058634477964 no 3323 0.00235772293164979 1087 2870194 SGTC_669 0108-0021 26.2 µM -2.84052765947052 0.0034448008160859 no 3324 0.0022519483505111 1075 17201 SGTC_3299 9121982 43.1275 µM -2.85071476543119 0.00334672761205866 no 3325 0.00218105403938389 1085 17594604 YPL160W CDC60 SGTC_2724 maprotiline 69.64 µM -2.87002681702957 0.00316767013954 no 3326 0.00205218494097716 1081 4011 A tricyclic antidepressant. SGTC_1791 st048313 56.1 µM -2.88463523037264 0.0030380024521138 no 3327 0.00195933708671338 1086 1204976 SGTC_1975 st070967 30.8 µM -2.90168335509949 0.00289273866234675 no 3328 0.00185581749756218 1089 261391 SGTC_3248 9135562 49.47 µM -2.91215742137628 0.00280662711261267 no 3329 0.00179470844270136 1087 17650701 SGTC_2335 9018011 154.17 µM -2.95487137188645 0.0024789009674371 no 3330 0.00156399717324319 1088 6458208 SGTC_1497 4476-2978 41.3 µM -2.96023787942527 0.0024402721366333 no 3331 0.00153700792180206 1090 1528379 SGTC_1914 st062367 72.6 µM -2.97019121423228 0.00237006538860007 no 3332 0.00148807218669128 1087 978205 SGTC_1496 4469-0713 57.4 µM -2.98167298629207 0.00229135212084007 no 3333 0.00143339018023729 1094 746691 SGTC_2126 5251174 33.877 µM -3.00762243449993 0.00212210817236126 no 3334 0.00131650019719461 1087 790722 SGTC_921 1561-0023 372 µM -3.01397587872126 0.00208243717208918 no 3335 0.00128924152837053 1088 24050882 SGTC_606 k015-0008 38.6 µM -3.03497962663003 0.0019560317223438 no 3336 0.00120275967914804 1093 1970475 SGTC_3347 9188721 44.724 µM -3.05489761406087 0.00184264036200489 no 3337 0.00112568682861975 1093 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_736 0958-0254 92.6 µM -3.06437236457964 0.00179082782067475 no 3338 0.00109063613835677 1094 6812352 SGTC_542 3381-0244 89.3 µM -3.07507776079993 0.00173388262587556 no 3339 0.00105223838614527 1095 1112843 SGTC_1792 st045773 43.6 µM -3.17376508542594 0.00128150209773278 no 3340 0.000752377122208394 1091 2919270 SGTC_2533 agelasine 13.65 µM -3.18112005833237 0.00125254794008941 no 3341 0.000733534088712818 1091 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1203 3992-3522 103 µM -3.20292299185764 0.00117019761707224 no 3342 0.000680201766978987 1087 5322312 SGTC_611 3453-1652 23.7 µM -3.36945980716054 0.000687126344844475 yes 3343 0.000376578372055451 1092 1560575 SGTC_2342 7990637 118.86 µM -3.38841812824046 0.000645777005168077 yes 3344 0.000351485058653908 1090 2033102 YER133W GLC7 SGTC_80 0159-0065 512.242 µM -3.40874901882722 0.000603994903323007 yes 3345 0.000326307458377634 1095 1548079 SGTC_2073 5212005 126 µM -3.53287558730455 0.000398514961686495 yes 3346 0.00020553293416006 1090 691789 SGTC_310 1273-0058 1.06 µM -3.5498335158975 0.000376132553965545 yes 3347 0.000192737422139721 1078 2734232 SGTC_2436 5633522 8.09 µM -3.56594144530502 0.000355958362893027 yes 3348 0.000181276160676886 1091 5724242 SGTC_2487 5918373 44.05 µM -3.61126587944876 0.000304458600518202 yes 3349 0.000152353040087448 1092 2876279 SGTC_1134 3477-0009 42.5 µM -3.72701999910685 0.000202681379276109 yes 3350 9.68785447896035e-05 1091 3973534 SGTC_160 3453-0671 289.699 µM -3.79483538616793 0.000158863657671989 yes 3351 7.38707231429352e-05 1092 5322268 SGTC_2407 paclitaxel 400 µM -4.11017043381482 4.86520529931375e-05 yes 3352 1.97683596341049e-05 1091 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2767 sibutramine 71.45 µM -4.225588860449 3.08963357087099e-05 yes 3353 1.19158379148237e-05 1094 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2327 6189656 200 µM -4.49822298061399 1.01084286622134e-05 yes 3354 3.42619039602105e-06 1093 5349088 SGTC_3315 9136395 68.55 µM -4.71766761720037 3.92856919991936e-06 yes 3355 1.19281915346842e-06 1094 16876844 SGTC_3210 9128157 49.47 µM -5.62745715229491 5.03647431903348e-08 yes 3356 9.14427858231672e-09 1093 17590849