SGTCid condition conc unit HXT4|YHR092C.score HXT4|YHR092C.strain.pval HXT4|YHR092C.strain.significant HXT4|YHR092C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2582 agaric acid 100 µM 8.63101936853136 2.79896640189231e-20 yes 1 3.04037925150663e-18 93 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2009 4012297 12.05 µM 5.42848616551959 3.43307510872613e-09 yes 2 2.84170251832573e-08 29 45595307
SGTC_2798 7813637 45.45 µM 5.41442333968885 3.7478840315031e-09 yes 3 3.07432692983786e-08 7 956368
SGTC_2802 7925815 54.55 µM 4.9210208523313 7.12019707345788e-08 yes 4 4.3046978060192e-07 20 1262923
SGTC_2248 tofa 1.1 µM 4.82657620740347 1.21446414716065e-07 yes 5 6.94501288840033e-07 29 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_58 0957-0393 9 µM 4.76763531410913 1.68660220378947e-07 yes 6 9.32003995749371e-07 310 6997992
SGTC_2602 kawain 100 µM 4.67798115891498 2.75983456143684e-07 yes 7 1.44856579469171e-06 12 5369129
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 4.49957719576387 7.16849233289872e-07 yes 8 3.40443755100039e-06 23 5377381
SGTC_607 4491-0986 66.8 µM 4.44768010192378 9.4029089522839e-07 yes 9 4.34013358223125e-06 16 698981 YDR232W HEM1
SGTC_2658 polymyxin b sulfate 77.05 µM 4.29612255608991 2.04306914059297e-06 yes 10 8.69057573187427e-06 33 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2821 7996764 71.43 µM 4.27170215898041 2.30993126808972e-06 yes 11 9.69932785462858e-06 28 2987135
SGTC_2450 5739737 12.93 µM 4.24989037948047 2.57625083026278e-06 yes 12 1.06937579353564e-05 19 2262825
SGTC_3157 9099274 49.47 µM 4.20927047629362 3.15252262750294e-06 yes 13 1.28098274784643e-05 15 17217662
SGTC_405 ebelactone b 50 µM 4.15646259573433 4.08791169911238e-06 yes 14 1.6160652969341e-05 14 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2355 9061122 103.12 µM 4.08968041256019 5.6542479383564e-06 yes 15 2.15983982089e-05 11 5302957
SGTC_1408 3909-7976 48.8 µM 3.86828508059533 1.60248642248345e-05 yes 16 5.4801740102879e-05 22 24152374
SGTC_1435 4092-0789 56.7 µM 3.68236802440815 3.69343484181072e-05 yes 17 0.00011553875001865 18 2248285
SGTC_1224 0823-0416 294 µM 3.67472131157052 3.81951825758961e-05 yes 18 0.000119054587305575 16 3598164
SGTC_1794 st048918 76.9 µM 3.53589614880175 6.95110975070234e-05 yes 19 0.000203197209656979 14 672303
SGTC_180 1486-1293 102.781 µM 3.45959749310238 9.57752333371264e-05 yes 20 0.000270491698202346 53 4140536
SGTC_1575 cyproterone acetate 48 µM 3.44320982086038 0.000102519608766815 yes 21 0.000287426564724108 38 9880 An androgen receptor antagonist and liver toxin.
SGTC_3027 9089541 49.47 µM 3.38186422174409 0.00013193496363778 yes 22 0.000359978602786104 39 9943819
SGTC_3067 9117431 49.47 µM 3.37042413139253 0.000138229841066701 yes 23 0.000375262848130588 31 17150885
SGTC_3255 9139072 49.47 µM 3.33643922994254 0.00015863008299688 yes 24 0.000424294892614561 34 17646060
SGTC_217 ketoconazole 989 nM 3.29355459784214 0.000188400144311271 yes 25 0.000494645631169896 47 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_179 1273-0063 6.77 µM 3.27929608413996 0.000199403487179229 yes 26 0.000520331941678738 37 3108139
SGTC_3242 9133940 49.47 µM 3.24093753384449 0.000232057752376009 yes 27 0.000595686436332768 28 17248444
SGTC_1873 rapamycin 2 nM 3.23920260548699 0.000233646547051108 yes 28 0.000599321974053973 105 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1394 3474-0001 65.7 µM 3.20808217939251 0.000263926781127894 yes 29 0.000668116552858774 68 5017666 YIL048W NEO1
SGTC_3110 9122132 49.47 µM 3.16701977098713 0.000309491361982383 yes 30 0.000770049236571777 39 918317
SGTC_1629 st005085 44.9 µM 3.16651010955073 0.000310100337215909 yes 31 0.000771399916513431 70 24207091
SGTC_1250 0485-0349 40.2 µM 3.15292840312194 0.000326745209360181 yes 32 0.000808207234203062 69 6842794 YDL195W SEC31
SGTC_2739 tacrine 100.86 µM 3.15167877847552 0.000328317694348682 yes 33 0.000811673755511495 43 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1635 st007035 42.4 µM 3.14771621105551 0.000333350714667321 yes 34 0.000822756812905576 277 3716403
SGTC_2354 9060492 162 µM 3.13357550291544 0.000351902079059621 yes 35 0.000863452419198964 54 6471895
SGTC_2126 5251174 33.877 µM 3.03270234800239 0.000514758631435302 yes 36 0.00121187269856423 93 790722
SGTC_1273 0849-0096 14.1 µM 2.93932953606816 0.000725177039411342 yes 37 0.00164461574353263 61 5286025
SGTC_1903 st060211 78.3 µM 2.93709132118589 0.00073107857584786 yes 38 0.00165653263325431 81 688960
SGTC_1948 st076329 66.6 µM 2.93145444362557 0.00074613806691505 yes 39 0.00168689422665636 84 24208413
SGTC_3236 9132701 49.47 µM 2.92808670248781 0.000755271187904702 yes 40 0.00170527462442822 66 24282524
SGTC_637 1181-0519 7.26 µM 2.90547049277931 0.000819322524452308 yes 41 0.00183350711370413 165 6252091 YGR060W ERG25
SGTC_762 1165-0429 115 µM 2.88508766711676 0.000881293219986136 yes 42 0.00195652339696031 73 5967793
SGTC_2060 5238662 140 µM 2.86734562327675 0.0009387127396917 yes 43 0.00206965346653158 72 790130
SGTC_2799 7812892 81.82 µM 2.86216993833047 0.000956099240803936 yes 44 0.00210375621241622 83 20205235
SGTC_252 miconazole 1.30953 nM 2.85990465819099 0.000963801558009706 yes 45 0.00211884194604292 97 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_922 1866-0035 480 µM 2.8330231483152 0.00105965561772858 no 46 0.00230550233835581 143 3156169
SGTC_2742 clothiapine 36.27 µM 2.81761818621672 0.00111845159386488 no 47 0.00241906525577165 55 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_997 3996-0078 137 µM 2.79319136730102 0.00121783439987677 no 48 0.00260954030719337 107 735687
SGTC_945 3381-0768 11.3 µM 2.77853167773804 0.00128129473822641 no 49 0.00273025943561947 100 1126236 YIL048W NEO1
SGTC_2770 toltrazuril 17.5 µM 2.7232414863584 0.00154879903275286 no 50 0.00323223930472927 101 68591 Kills coccidiodes.
SGTC_857 0438-0306 1.35 µM 2.70919660258981 0.00162441456525176 no 51 0.00337231800381767 61 4686136
SGTC_1565 sinapyl alcohol 95.1 µM 2.69748203645797 0.00169004019802365 no 52 0.00349330270633897 109 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2629 bisabolol 100 µM 2.68493087798541 0.00176302362927522 no 53 0.00362724038303967 104 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1172 0370-0043 85 µM 2.67705311500953 0.00181028483994778 no 54 0.00371364297548179 92 376585
SGTC_1956 st077085 54 µM 2.67682529980289 0.00181166855958729 no 55 0.00371616886812711 95 24208685
SGTC_1291 0993-0025 5.79 µM 2.64680850859357 0.00200262744662317 no 56 0.00406276752206099 65 4353356
SGTC_2381 9035592 200 µM 2.59602256715118 0.00236771037729651 no 57 0.00471549354046328 95 4749657
SGTC_620 0109-0052 432 µM 2.58222621780426 0.0024767902214737 no 58 0.00490826077761952 92 493037
SGTC_540 1187-0821 17.3 µM 2.55555834966992 0.00270060803541539 no 59 0.00530087922503381 112 847520
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.54960151212533 0.00275303258105056 no 60 0.0053923054603512 124 3256 An antibiotic and ribosome inhibitor.
SGTC_537 1334-0398 209 µM 2.52571013464021 0.00297264741756772 no 61 0.00577323529313453 114 5846986
SGTC_1875 nocodazole 6 µM 2.50723349760169 0.00315318155330021 no 62 0.00608401504481751 122 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1164 k060-0068 93.7 µM 2.48807808173905 0.00335071035050785 no 63 0.00642177656881886 133 5963676
SGTC_2084 5306078 60.6385 µM 2.4323826267217 0.00398975958447547 no 64 0.00749992610670119 128 679340
SGTC_2701 st077767 14.721 µM 2.43198545282863 0.00399468425608268 no 65 0.00750815520215321 171 5721188
SGTC_320 4092-0846 5.34 µM 2.43097473260711 0.00400724102199027 no 66 0.00752913232386502 145 1359356
SGTC_1045 1348-1485 165 µM 2.41567307404169 0.00420170810688217 no 67 0.00785307809716633 171 6810614
SGTC_2026 5148700 152 µM 2.40950871436099 0.00428240621245351 no 68 0.00798700728810046 125 79838
SGTC_326 k292-0812 17.5 µM 2.37568805514336 0.00475030428090804 no 69 0.00875813207534969 80 3579357
SGTC_2229 7354935 190 µM 2.35958243647755 0.00498874216849227 no 70 0.0091477577192478 72 318112
SGTC_2375 9072683 200 µM 2.3564412267836 0.00503647000477782 no 71 0.00922549358162575 164 16798029
SGTC_3006 9075424 71.4286 µM 2.34930947212186 0.00514634321135314 no 72 0.0094041335540946 128 7465181
SGTC_227 fluconazole 33.516 µM 2.34634119969878 0.00519269824931339 no 73 0.00947937156791434 216 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3128 9127691 49.47 µM 2.34548987467805 0.005206061640758 no 74 0.00950104735277971 119 41316314
SGTC_3288 9119690 36.221 µM 2.33864149148278 0.00531467980783079 no 75 0.00967699777674971 122 17595618 YKL019W RAM2
SGTC_2913 7966556 36.57 µM 2.32108896689857 0.00560232595086778 no 76 0.0101410213650937 114 2976516
SGTC_1076 itraconazole 331 nM 2.2948903443016 0.00605739483503844 no 77 0.0108697046532928 148 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1350 1495-0454 146 µM 2.28941891422789 0.00615646831416511 no 78 0.0110275121084206 180 1069057
SGTC_1449 4112-4002 201 µM 2.28701253069791 0.00620049434581348 no 79 0.0110975458523508 129 2059539
SGTC_1775 st081588 35.1725 µM 2.28432484457682 0.00624999640600933 no 80 0.0111762234128599 166 1426443 YGL099W LSG1
SGTC_782 0083-0095 30.5 µM 2.27836678216296 0.00636098218962524 no 81 0.0113523669006632 187 3591729 An indicator and reagent.
SGTC_377 3970-0964 33.1 µM 2.27223215624284 0.00647707616107724 no 82 0.0115362460160058 242 16481235
SGTC_3138 9097216 49.47 µM 2.270531665161 0.00650958692569519 no 83 0.0115876721473808 138 25237486
SGTC_232 clozapine 119 µM 2.26162383398198 0.00668226033653012 no 84 0.0118603270851076 211 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1201 1889-3372 45.9 µM 2.23847476688747 0.00715006090106784 no 85 0.0125950555602069 119 5392199
SGTC_2193 5925765 200 µM 2.22723377809104 0.00738746816770764 no 86 0.0129658268639662 115 877370
SGTC_248 streptozotocin 5.23457 mM 2.22532135367484 0.00742854238443736 no 87 0.0130298364730165 167 5300 DNA alkylating agent.
SGTC_321 4534-3890 65.3 µM 2.19432987047983 0.00812278260452726 no 88 0.0141058517679765 122 699746
SGTC_1483 3453-0561 55.9 µM 2.18768739530639 0.00827879362740972 no 89 0.0143461904200781 182 4546991
SGTC_1427 4048-4900 550 nM 2.18432266488305 0.00835882018682772 no 90 0.01446927323002 164 24132586
SGTC_3266 9136860 49.47 µM 2.1831960233764 0.00838576753558547 no 91 0.0145106887462081 209 4871271 YPR165W RHO1
SGTC_1405 3909-7894 12 µM 2.18091739382487 0.00844050168012172 no 92 0.0145947634730043 152 7104060
SGTC_10 0279-0212 42.575 µM 2.16360376348328 0.00886672762930687 no 93 0.0152473862288817 337 39851 YBR002C RER2
SGTC_367 0335-0881 7.1 µM 2.16332036516059 0.00887385843221172 no 94 0.0152582738975714 243 23828853
SGTC_2651 TUB2.036 5 µM 2.1594678370708 0.00897129452182533 no 95 0.015406944980052 394 15992207 YFL037W TUB2
SGTC_327 1273-0057 3.96 µM 2.15735989978561 0.00902500303313451 no 96 0.0154888165737033 175 3108138
SGTC_946 3434-1334 87.4 µM 2.15595323734657 0.00906100011341568 no 97 0.0155436583970918 174 4047976
SGTC_2878 9043973 25.97 µM 2.14858613728528 0.0092515882516727 no 98 0.0158336107781738 147 6465167
SGTC_2181 6316240 54.2555 µM 2.14690721604299 0.00929550992448507 no 99 0.015900334513796 167 12779990
SGTC_1101 ebselen 5.29 µM 2.13927628153476 0.00949744722721515 no 100 0.0162066497199094 184 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_137 0438-0332 85.389 µM 2.13849031471494 0.00951846255088283 no 101 0.0162384846862094 343 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3208 9114115 49.47 µM 2.12075359211362 0.0100036419240102 no 102 0.0169712719744043 215 650895
SGTC_1831 st055328 12 µM 2.12034528335175 0.0100150606626884 no 103 0.0169884687205725 196 1103068
SGTC_2464 5717415 7.67 µM 2.10416932215389 0.0104766843003963 no 104 0.0176818397782215 190 5285744
SGTC_2004 4023728 41.89 µM 2.09897558143553 0.0106287826662691 no 105 0.017909526667698 222 360084 YDR527W RBA50
SGTC_3142 9086498 49.47 µM 2.09055003575526 0.0108796160755693 no 106 0.0182842093167096 196 25236367
SGTC_934 2950-0684 338 µM 2.05876986542538 0.011872660412157 no 107 0.0197581448689604 198 1121253
SGTC_1826 st055655 41.6 µM 2.03369233115699 0.0127108786000576 no 108 0.0209913129292501 236 676168
SGTC_1655 st012546 55.1 µM 2.02591542187048 0.0129810156692736 no 109 0.0213867262957612 199 720985 YLR208W SEC13
SGTC_2586 curcumin 80 µM 2.02411227802313 0.0130443534911893 no 110 0.0214793002974433 292 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2741 miltefosine 3.04 µM 2.02080514962828 0.0131612152609004 no 111 0.0216499697718671 160 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_345 1362-0200 395 µM 2.01104493771041 0.0135113948792689 no 112 0.0221603551733363 205 1419823
SGTC_2536 dehydroabietamide 32.04 µM 2.0075480748422 0.0136387987049198 no 113 0.0223456685484212 247 3983547
SGTC_1758 st042942 75.2445 µM 1.9995240596898 0.0139350679792778 no 114 0.0227758406584295 201 669317
SGTC_1559 coumarin 343 70.1 µM 1.99898172314772 0.013955291254602 no 115 0.0228051657106914 180 108770 A hepatotoxic, DNA x-linker.
SGTC_1456 k015-0012 13 µM 1.99647202277217 0.0140492056665682 no 116 0.0229412840398743 259 2989616
SGTC_1479 0549-0158 134 µM 1.99622953068859 0.0140583086497884 no 117 0.02295447223772 245 5440202
SGTC_226 1,3-diallylurea 8.28947 mM 1.98907901389187 0.0143290284411637 no 118 0.0233462411605584 191 74537 YKL182W FAS1
SGTC_3056 9094900 49.47 µM 1.98616190367674 0.014440753373651 no 119 0.0235076747297514 235 25236784
SGTC_3298 9116858 71.43 µM 1.97323535152414 0.0149449083854938 no 120 0.024234377278025 208 2506942
SGTC_712 r015-0009 80.6 µM 1.95941942363698 0.0155004066269153 no 121 0.0250318438892029 200 6813872 YLR060W FRS1
SGTC_1799 st045822 46.1415 µM 1.94748411109189 0.0159944689643597 no 122 0.0257383614110741 202 3674992
SGTC_959 1222-0044 107 µM 1.94287923247813 0.0161886649265187 no 123 0.0260153758544225 240 6083612
SGTC_1036 k216-0215 33.5 µM 1.93724012274152 0.0164292246572417 no 124 0.0263579988952161 295 622330
SGTC_183 3914-0051 30.55 µM 1.93305184925817 0.016609867740909 no 125 0.0266149054325821 237 1596232
SGTC_2906 7926292 26.41 µM 1.93026495594318 0.0167310078800023 no 126 0.0267870084103736 251 2966319
SGTC_2421 5690543 90.72 µM 1.92860935745152 0.016803330380924 no 127 0.0268896882460606 248 3397993
SGTC_2919 7978188 46.38 µM 1.92601321419462 0.0169172776239521 no 128 0.0270513619438647 233 2980291
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.9209118516407 0.0171431069429416 no 129 0.0273714106807159 244 2333 A French combination drug.
SGTC_3253 9135987 49.47 µM 1.91881773695521 0.0172365531902658 no 130 0.027503702164945 186 4182430
SGTC_1798 st045719 60.953 µM 1.91543058254729 0.0173886202438499 no 131 0.0277188070322114 172 3980186
SGTC_157 1348-1695 65.819 µM 1.91480714329266 0.0174167341781124 no 132 0.0277585515817984 340 5380510
SGTC_2111 5486399 200 µM 1.91263800636439 0.0175148538649022 no 133 0.027897205298845 290 689674
SGTC_2707 st078556 66.6 µM 1.90968049470063 0.0176493953071203 no 134 0.0280871819417839 205 17250899
SGTC_1450 4112-4260 37.6 µM 1.90667462708145 0.0177870392841104 no 135 0.0282813673062156 255 1633175
SGTC_2461 5755302 26.15 µM 1.90155732428015 0.0180234763396292 no 136 0.0286145257852787 285 2788904
SGTC_1346 1488-2224 62.4 µM 1.89838630236692 0.0181713290759904 no 137 0.0288226063426103 230 3722427
SGTC_2937 9044753 11.33 µM 1.89622325131902 0.0182727759444271 no 138 0.0289652649323998 300 6465530 YGL099W LSG1
SGTC_2816 7982706 58.44 µM 1.89471253140292 0.0183439144182151 no 139 0.0290652483183403 297 2981853
SGTC_314 1671-0008 2.74 µM 1.89238684573871 0.0184538900305808 no 140 0.0292197286865754 316 3913060
SGTC_246 cycloheximide 667 µM 1.88818816992022 0.0186538566243746 no 141 0.0295003467104693 198 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1028 k015-0029 4.8 µM 1.88542959327217 0.0187862384689155 no 142 0.0296859308792398 306 4588309
SGTC_754 3474-0146 171 µM 1.88494919030339 0.0188093741575065 no 143 0.0297183489899737 254 24762078
SGTC_3132 9126706 49.47 µM 1.88030929612301 0.0190340769450185 no 144 0.0300329685473035 244 850858
SGTC_3240 9133527 49.47 µM 1.87318406901414 0.0193835830845771 no 145 0.0305214857207845 231 17617455
SGTC_1023 4482-3888 16 µM 1.86526274361614 0.0197785252083229 no 146 0.0310722923128417 249 3303168
SGTC_3260 9137109 49.47 µM 1.86401047564444 0.0198415819380147 no 147 0.0311601166235203 171 17478346
SGTC_2006 4011487 200 µM 1.86396961906692 0.019843642101743 no 148 0.0311629854407891 355 45595294
SGTC_3225 9130819 49.47 µM 1.8631638072942 0.0198843116982175 no 149 0.0312196116121056 262 4547121
SGTC_790 1575-0012 79.1 µM 1.85870046062175 0.0201108614140388 no 150 0.031534804075234 277 378741 YLR208W SEC13
SGTC_1379 2144-0755 36.5 µM 1.85137629068851 0.0204873629629776 no 151 0.0320577187700454 290 5392327
SGTC_1277 0873-0036 22 µM 1.85105526873563 0.0205040009272388 no 152 0.0320808011846595 318 5965735
SGTC_687 k029-0044 34.9 µM 1.84527535091178 0.0208055274533629 no 153 0.0324987471135461 245 5829338
SGTC_2524 avocatin b 10.57 µM 1.8417989078138 0.020988688203413 no 154 0.0327522849461123 229 6710748
SGTC_2314 7727897 200 µM 1.83604799420692 0.021294677735695 no 155 0.0331752793835831 252 900724
SGTC_2301 7769476 200 µM 1.8354751340589 0.0213253635440804 no 156 0.0332176600745239 232 977820
SGTC_312 4092-0653 6.84 µM 1.83541075776829 0.0213288142582984 no 157 0.033222425474483 391 1148278
SGTC_1895 st058434 18.3 µM 1.82810016564238 0.0217237615709282 no 158 0.0337672600555787 270 5393175
SGTC_2426 5582046 32.21 µM 1.81199087850103 0.0226158957984149 no 159 0.0349938029624988 300 2251934
SGTC_3049 9092223 49.47 µM 1.81014642669696 0.0227199850891164 no 160 0.035136541471071 252 8623917
SGTC_2681 menadione 3.18 µM 1.79997758120569 0.0233011266062282 no 161 0.0359320891159985 281 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2766 oltipraz 83.91 µM 1.79920230223142 0.0233459419082555 no 162 0.0359933427069244 269 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_503 tyrphostin 8 294 µM 1.79883365953812 0.0233672768751262 no 163 0.03602249858366 303 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3339 9145883 14.936 µM 1.79758626914045 0.0234395905462271 no 164 0.0361212979350514 257 2030670
SGTC_852 0418-0143 439 µM 1.79456489223035 0.0236155264020621 no 165 0.0363615254623452 356 5369229
SGTC_1267 0828-0272 9.49 µM 1.78955793317732 0.0239095283303975 no 166 0.0367625031394689 297 745334
SGTC_1283 0922-0125 16.4 µM 1.78173691357901 0.0243749204198449 no 167 0.0373960721269641 306 3360884
SGTC_689 0833-0039 98 µM 1.77634623833651 0.0247001025154783 no 168 0.0378379332169528 286 5374726
SGTC_2353 9059630 146.67 µM 1.77490882124073 0.0247874240086646 no 169 0.037956471762714 237 4779114
SGTC_1855 st056195 39.6 µM 1.77041176551927 0.0250622890773312 no 170 0.0383292855971462 297 4028379
SGTC_1314 1222-0010 41.1 µM 1.75858281156939 0.0257975104765825 no 171 0.0393241972850608 276 3526027
SGTC_1619 st003326 88.7 µM 1.75826912766477 0.025817250404777 no 172 0.0393508640047873 243 2849032
SGTC_882 0843-0131 351 µM 1.75407159559661 0.0260826168999495 no 173 0.0397091200196172 315 5425421
SGTC_3269 9137823 49.47 µM 1.75074577905777 0.0262944902112116 no 174 0.0399948550219613 263 17682936
SGTC_1568 digitonin 820 nM 1.74765879287895 0.0264924342810414 no 175 0.0402615641118101 335 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_702 1488-0190 94 µM 1.74357657617928 0.0267561051599321 no 176 0.0406164753647822 266 949357
SGTC_2473 5854593 8.94 µM 1.73963122005031 0.0270130151498706 no 177 0.0409618967987266 264 2872951
SGTC_1850 st056238 17 µM 1.72997222875201 0.0276506812116523 no 178 0.0418176185516318 342 5393177
SGTC_2896 9052656 71.43 µM 1.72664548082005 0.0278731903622291 no 179 0.0421156762668892 488 6469436
SGTC_1914 st062367 72.6 µM 1.71464856939309 0.0286880265971568 no 180 0.0432048391101357 298 978205
SGTC_2407 paclitaxel 400 µM 1.71198628672914 0.0288715107381024 no 181 0.0434495978308419 373 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3108 9121785 49.47 µM 1.71065774106971 0.0289634381525163 no 182 0.0435721565462704 314 17140271
SGTC_189 3970-0742 2.116 µM 1.70506039946743 0.0293534161545942 no 183 0.0440915801368953 264 2891807
SGTC_1700 st030840 7.9285 µM 1.70414181073063 0.0294178307018569 no 184 0.0441772985433741 329 5499307
SGTC_2469 5655019 90.81 µM 1.69993624287527 0.0297142397969152 no 185 0.0445714593822685 329 2788239
SGTC_685 1278-0033 54.9 µM 1.69792944503866 0.0298565502075068 no 186 0.0447605395312349 347 3590572
SGTC_2310 7668677 200 µM 1.69158676852686 0.0303100576985015 no 187 0.0453623955263202 335 2197143
SGTC_816 0325-0417 81.3 µM 1.68785256794886 0.0305797162588009 no 188 0.0457197668291937 292 68101
SGTC_1400 3771-8998 51.5 µM 1.68487536234989 0.0307961307303859 no 189 0.046006310472549 284 670767
SGTC_2441 5730946 39.09 µM 1.68424377140829 0.0308422040173455 no 190 0.0460672835839598 341 1774275
SGTC_2210 7115885 190.385 µM 1.68416719009583 0.0308477943464286 no 191 0.046074681072091 317 2927039
SGTC_1769 st044406 64.4 µM 1.67715334730065 0.0313633627169374 no 192 0.0467562495688111 353 670903
SGTC_2318 6029776 164 µM 1.66476442553733 0.0322914391990938 no 193 0.0479798819473075 361 818325
SGTC_2479 5617353 43.85 µM 1.65639368162643 0.0329312476218667 no 194 0.0488210599042069 359 2731746
SGTC_793 0488-0545 106 µM 1.65062134098592 0.0333785083929686 no 195 0.0494079592092691 337 292548
SGTC_965 1291-5240 308 µM 1.64283064513557 0.0339900777023069 no 196 0.0502089888960042 360 2834598
SGTC_768 0384-0033 77.3 µM 1.6384424881438 0.0343385856534245 no 197 0.0506647110217778 432 3965305 YMR134W ERG29
SGTC_3237 9133362 49.47 µM 1.63747477308738 0.0344158355928075 no 198 0.0507656529088161 342 43845137
SGTC_2288 7946289 167.31 µM 1.63558656453966 0.034566977054422 no 199 0.0509630720722185 411 1246052
SGTC_2885 9057732 51.95 µM 1.63499739939386 0.0346142481716732 no 200 0.0510247963963553 340 6471414
SGTC_2747 doxorubicin 7.63 µM 1.63107498889821 0.0349303142376987 no 201 0.0514372487099843 208 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3346 9158254 43.5805 µM 1.617210902859 0.0360665127518246 no 202 0.0529163818320869 374 17639500
SGTC_1336 1486-0901 104 µM 1.61600377878751 0.0361668559483705 no 203 0.0530467480989914 356 5006114
SGTC_784 4579-0127 173 µM 1.61474412115799 0.0362718096462885 no 204 0.0531830592727503 376 1948547
SGTC_1994 st072947 40.9 µM 1.61081021551047 0.0366011858076159 no 205 0.05361054693026 362 5286565 YDL195W SEC31
SGTC_2807 7945238 51.95 µM 1.61057736891304 0.036620757928413 no 206 0.0536359348657602 386 17148797
SGTC_2899 9053889 58.44 µM 1.61033749485528 0.0366409297008157 no 207 0.0536620989836769 313 6470052
SGTC_1371 2421-0008 32.7 µM 1.60792751085476 0.0368440977291165 no 208 0.0539255278918067 388 2827552
SGTC_1220 1838-0075 193 µM 1.60557265918844 0.0370435068225141 no 209 0.0541839183725888 373 5529645
SGTC_1009 4106-0057 9.87 µM 1.6009392558123 0.0374384393211159 no 210 0.054695186920601 378 2928005
SGTC_185 k048-0037 25.491 µM 1.59788948829017 0.0377002608697125 no 211 0.0550337869472221 355 6827589
SGTC_2049 5262831 67.185 µM 1.59245541342251 0.0381704776611613 no 212 0.0556412068752103 369 763417
SGTC_526 4469-0568 170 µM 1.58406918673847 0.0389055242017617 no 213 0.0565889877399194 377 2901964
SGTC_2841 9004761 38.96 µM 1.58372836602519 0.0389356389550984 no 214 0.0566277733916978 349 2991039
SGTC_1766 st045414 44.774 µM 1.58118572868772 0.0391609046691737 no 215 0.0569177887443573 409 253960
SGTC_73 0327-0325 16.231 µM 1.57924419145276 0.0393336290862276 no 216 0.057140028631093 448 53298
SGTC_1896 st058441 89 µM 1.57476116005827 0.0397348204057916 no 217 0.057655792343764 342 688759
SGTC_2253 7938677 135.83 µM 1.57436080348254 0.0397708099945275 no 218 0.0577020300641405 355 2301972
SGTC_2370 9071495 200 µM 1.57381027632879 0.0398203422645209 no 219 0.0577656587957082 378 21791103
SGTC_2396 5342950 42.78 µM 1.5727802967905 0.0399131467068813 no 220 0.0578848497324792 442 1886677
SGTC_256 clotrimazole 625 nM 1.56820940307145 0.0403271221240077 no 221 0.0584161353344676 392 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1809 st050081 57.6 µM 1.56609993082489 0.0405193447016829 no 222 0.0586626121505742 364 5036894
SGTC_319 1348-1596 45.5 µM 1.56349205851177 0.0407580107357884 no 223 0.0589684510793991 404 5380505
SGTC_218 alverine citrate 93.75 µM 1.56099238963065 0.0409878437182696 no 224 0.0592627732580373 346 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2560 caryophyllene 100 µM 1.55899730431451 0.0411720359238678 no 225 0.0594985090934578 434 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1534 6-azauridine 81.6 µM 1.55702939423922 0.0413543761268622 no 226 0.0597317533654332 450 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_609 0986-0026 86.3 µM 1.55625674845541 0.041426145692827 no 227 0.0598235259292891 424 2848610
SGTC_3300 9124615 50.48 µM 1.55402674299239 0.0416338527905532 no 228 0.0600890188430866 395 24824903
SGTC_1000 4048-0884 8.67 µM 1.55124742963663 0.0418939035729969 no 229 0.0604211998898239 401 13040088
SGTC_1182 1222-0449 220 µM 1.548565781848 0.0421460612313014 no 230 0.0607430684856476 362 658318
SGTC_1132 3456-3614 2.5 µM 1.54304652170661 0.0426689074106743 no 231 0.0614097443710917 502 3125502
SGTC_968 1309-0633 340 µM 1.53853459753975 0.0431002122334405 no 232 0.061958977966754 385 3761976
SGTC_360 0957-0399 1.01 µM 1.52854825421345 0.0440673552829844 no 233 0.0631882361980443 434 6752301 YPR165W RHO1
SGTC_987 1497-1013 404 µM 1.52791962958697 0.0441288161834195 no 234 0.0632662469215831 343 1676435
SGTC_840 0245-0196 390 µM 1.52382533343625 0.0445308099818923 no 235 0.063776174687888 453 3827528
SGTC_1482 3346-2049 8.48 µM 1.51841967023883 0.0450660719431535 no 236 0.0644543180111892 399 3826804
SGTC_1388 3346-4487 254 µM 1.51792091107799 0.0451157182562731 no 237 0.0645171688511968 453 3345614
SGTC_1383 3049-0032 20.7 µM 1.50990737880363 0.0459194329223085 no 238 0.0655335298007996 425 712864
SGTC_138 0850-0259 40.9225 µM 1.50625045161744 0.046290006466465 no 239 0.066001446214493 597 6813004
SGTC_2072 5231554 129 µM 1.50586520139536 0.0463291850864204 no 240 0.0660508906456904 395 789545
SGTC_3248 9135562 49.47 µM 1.50035104731185 0.0468928783982972 no 241 0.0667617464346447 431 17650701
SGTC_2017 5132927 60.65 µM 1.49628278530844 0.0473122789795766 no 242 0.0672899895880576 435 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2259 7964009 200 µM 1.49591783485506 0.0473500484966891 no 243 0.0673375340353002 386 313134
SGTC_1222 0366-0074 1.18 µM 1.4941978540594 0.0475283784415097 no 244 0.0675619566718272 437 286520
SGTC_546 peri-Naphthalide 147 µM 1.49211055052523 0.0477455151174877 no 245 0.0678350832355152 423 223824 A penicillin ester.
SGTC_2787 5284540 71.43 µM 1.48158297569767 0.0488528046766887 no 246 0.0692256458141211 438 736958
SGTC_1158 4092-0494 91.8 µM 1.48140319710595 0.0488718904865122 no 247 0.0692495816473317 444 1148199
SGTC_1641 st009299 47.1 µM 1.47782916116912 0.049252558478502 no 248 0.0697267554695745 345 4046054
SGTC_223 busulfan 5 mM 1.47759216798766 0.0492778839234225 no 249 0.0697584859718757 339 2478 A DNA alkylator.
SGTC_1503 4585-0012 61.3 µM 1.47580216292996 0.0494695025505085 no 250 0.0699985049725155 398 2922052
SGTC_817 1391-0715 46 µM 1.46849524502326 0.0502578790821803 no 251 0.0709848734527073 408 1353946
SGTC_355 1311-2252 105 µM 1.46657522259233 0.0504666918583596 no 252 0.0712458221851221 457 5338538
SGTC_610 4215-0184 155 µM 1.4597360955924 0.0512161051747527 no 253 0.0721813087831907 464 5605015
SGTC_2852 9023854 51.95 µM 1.45060437004679 0.0522305088775578 no 254 0.0734450288694406 471 19798528
SGTC_1871 st057448 67.3 µM 1.44557058142915 0.0527964752231708 no 255 0.0741488414783068 473 691747
SGTC_2678 equilin 100 µM 1.43973898246366 0.0534582134740575 no 256 0.0749706300055276 463 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_868 0527-0199 213 µM 1.43614417340852 0.053869396242806 no 257 0.075480660341187 476 2849450
SGTC_1511 0906-3109 28.5 µM 1.42702554326081 0.0549236427463257 no 258 0.0767862660646486 582 2882180
SGTC_1752 st044819 83.042 µM 1.42161094176021 0.0555573239467618 no 259 0.0775696132959488 467 441209 YML126C ERG13
SGTC_1707 st032323 6.317 µM 1.41679571092724 0.056125695250875 no 260 0.0782713320365115 497 3132057 YMR211W DML1
SGTC_507 nimesulide 162 µM 1.41635306446295 0.0561781728290681 no 261 0.0783360792962807 475 4495 A COX2 inhibitor.
SGTC_2874 9043904 71.43 µM 1.41558656294315 0.0562691362647372 no 262 0.0784482938745588 376 4463428
SGTC_2340 7987427 183.45 µM 1.4144405068315 0.0564053593344949 no 263 0.0786163018966511 463 2239331
SGTC_633 0437-0093 97.7 µM 1.41398728313502 0.0564593022942893 no 264 0.0786828181826405 441 2831118
SGTC_3287 9117173 37.0625 µM 1.40748580895843 0.0572375945103235 no 265 0.0796416911822545 381 2789709
SGTC_1458 k015-0034 6.33 µM 1.40614649068188 0.0573989684502956 no 266 0.0798403148097743 445 3598957
SGTC_3026 9090633 49.47 µM 1.40391443671058 0.0576687029011666 no 267 0.0801721650790226 485 25236842
SGTC_1609 st001574 46.4 µM 1.40259085940989 0.0578291219013203 no 268 0.0803694395408982 482 3960012
SGTC_2714 st079313 56.9 µM 1.40204500836194 0.0578953817247749 no 269 0.08045090342788 458 2939799
SGTC_426 0988-0037 14.6 µM 1.39991401702976 0.0581546301434256 no 270 0.0807695340208696 549 5383008
SGTC_725 1497-0963 19 µM 1.39843574794445 0.0583350060175272 no 271 0.0809911272773737 484 3549977
SGTC_1876 myriocin 605 nM 1.39442711475253 0.0588263443959018 no 272 0.0815943324210378 482 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_931 2812-0076 566 µM 1.39106077400088 0.0592414606761047 no 273 0.0821034992220607 501 3450959
SGTC_1936 st074407 74.3 µM 1.38701147554834 0.0597438345253578 no 274 0.0827191318160791 531 809813
SGTC_369 0957-0393 4.5 µM 1.3844159413443 0.0600675993125194 no 275 0.0831155652400097 458 6997992
SGTC_1425 4048-4433 7.33 µM 1.38136239085719 0.0604502537433323 no 276 0.0835837817818319 543 23734946
SGTC_475 α-linolenic acid 10 µM 1.3812258129799 0.0604674134066229 no 277 0.0836047701786185 511 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2944 9067346 25.62 µM 1.37634599247448 0.0610830191617161 no 278 0.0843572700265396 503 6473075
SGTC_1955 wogonin 32.4 µM 1.37394308526565 0.0613879485513609 no 279 0.0847296761729161 466 5281703 A flavanone.
SGTC_658 3253-0951 102 µM 1.36985916089379 0.0619089257323861 no 280 0.0853654350675714 615 1184878
SGTC_2936 9038235 15.59 µM 1.36637399079424 0.0623562444556907 no 281 0.0859108040276037 491 4749415
SGTC_1211 1056-0033 32.3 µM 1.36018656377156 0.0631566004716004 no 282 0.0868854466781748 515 6741922
SGTC_2401 5128683 200 µM 1.35911126942019 0.0632965042815639 no 283 0.0870556661538536 476 708373
SGTC_3162 9099653 49.47 µM 1.35884108012232 0.0633316958249528 no 284 0.0870984763441013 437 25237511
SGTC_259 usnic acid 108.925 µM 1.35257913106988 0.0641515749836757 no 285 0.0880950615653024 526 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1354 1498-1681 81 µM 1.34952022745245 0.0645550664514926 no 286 0.0885849638765543 553 5754243
SGTC_2382 9035899 200 µM 1.34753045236109 0.064818588587444 no 287 0.0889047262693757 524 6462679
SGTC_19 0279-0214 38.434 µM 1.346029841289 0.0650178786398087 no 288 0.0891464464664365 625 3566274 YBR002C RER2
SGTC_1603 st002045 67.8 µM 1.34589628769594 0.0650356383709036 no 289 0.089167983114075 508 5887985
SGTC_192 3455-0609 60.9 µM 1.341556557207 0.0656147797833483 no 290 0.0898699100197337 509 3769639
SGTC_2094 5332512 191.667 µM 1.33927327711816 0.0659210870084316 no 291 0.0902408624701278 542 755774
SGTC_1041 0206-0046 107 µM 1.33702071576024 0.0662243579287487 no 292 0.0906079374642903 511 50494
SGTC_2347 9049783 174.81 µM 1.3369110632245 0.0662391484034792 no 293 0.090625834572954 562 6467988 YPL169C MEX67
SGTC_3101 9120531 49.47 µM 1.33525693628063 0.0664625757207687 no 294 0.0908961338966868 541 24824904
SGTC_692 k241-0027 77.8 µM 1.33261803865677 0.0668202259408238 no 295 0.091328591210416 503 3600480
SGTC_3345 9148410 3.559 µM 1.33158612416778 0.0669604857881743 no 296 0.0914981135316089 468 4903596
SGTC_1741 st038134 10.228 µM 1.33123205334077 0.0670086642320159 no 297 0.0915563337890077 557 1272587
SGTC_280 3448-3607 3.04 µM 1.32580829926254 0.0677500302223452 no 298 0.0924516016540396 505 626179
SGTC_249 wiskostatin 11.211 µM 1.32110293928107 0.0683983184747682 no 299 0.093233521574272 532 2775510 A n-wasp and actin depolymerizer.
SGTC_3332 9141069 11.198 µM 1.31924237308329 0.0686559773697163 no 300 0.0935440482409394 473 17332883
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.31796100600463 0.0688338612119755 no 301 0.0937583508606006 583 676296 Flavone; oxidizing agent.
SGTC_1848 st056003 16.4 µM 1.31614287127056 0.0690868705229813 no 302 0.0940630470093966 562 146492
SGTC_2513 baicalein 25.65 µM 1.3110189501971 0.0698037650861731 no 303 0.0949256806784523 532 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2184 6075246 200 µM 1.30883412476805 0.070111182486985 no 304 0.095295272440819 540 2267320
SGTC_1730 st033808 45.1 µM 1.30865509413089 0.0701364192129869 no 305 0.0953256047116558 607 1045166
SGTC_2236 dapsone 200 µM 1.30452364455513 0.0707207446053104 no 306 0.0960275515630815 556 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_372 0155-0182 15.9 µM 1.30417357111274 0.0707704281259001 no 307 0.0960872044051324 593 771486
SGTC_292 k038-0015 474 µM 1.30259363418932 0.0709949914387322 no 308 0.0963567661127763 506 46368540
SGTC_467 ro 31-8220 72.8 µM 1.30129524996315 0.0711799457955863 no 309 0.0965787062554559 573 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_716 1683-5115 658 µM 1.30070307349505 0.0712644238639871 no 310 0.0966800549250509 622 723597
SGTC_2272 7805186 180 µM 1.29670940835461 0.0718361590482663 no 311 0.0973655954693279 533 2956062 YPR165W RHO1
SGTC_1089 terbinafine 2.25 µM 1.29314590817503 0.0723492755559863 no 312 0.0979802998941193 535 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3032 9089427 49.47 µM 1.291474514478 0.0725909087503615 no 313 0.0982695934133357 503 17173707
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.28957885418947 0.0728657116732878 no 314 0.0985984607702483 467 77254
SGTC_985 1493-0307 8.71 µM 1.2828726462307 0.0738442666970811 no 315 0.0997683487625824 487 3278274
SGTC_1828 st055811 49 µM 1.26941085819486 0.0758388544241331 no 316 0.102147282750041 505 5877589
SGTC_3200 9114385 49.47 µM 1.26863547627122 0.0759549778463579 no 317 0.102285552611753 524 17018030 YLR208W SEC13
SGTC_2522 biochanin a 4.94 µM 1.26792011575453 0.0760622323182418 no 318 0.102413239851018 526 5280373 A possible chelator.
SGTC_51 1013-0126 23.419 µM 1.26653409978761 0.0762703666573038 no 319 0.102660964524973 543 1627850
SGTC_1965 Pectolinarigenin 58.4 µM 1.26637278895388 0.0762946184072208 no 320 0.102689824118013 572 5320438 An anti-inflammatory.
SGTC_991 3996-0057 64.7 µM 1.26381394650189 0.0766801044801693 no 321 0.103148407110541 558 715343
SGTC_548 1436-0017 110 µM 1.26160099754535 0.0770146750125909 no 322 0.103546198524607 665 9677137
SGTC_1874 staurosporine 7.6 µM 1.25881803799015 0.0774369976548053 no 323 0.104048031763399 598 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1900 st060200 72.8 µM 1.25535064800677 0.0779656427766546 no 324 0.10467574828041 576 688945
SGTC_1200 1643-0193 18.4 µM 1.25362568656534 0.0782296516862976 no 325 0.104989045158535 619 5403974
SGTC_1121 fusaric acid 630.51 nM 1.25320571137994 0.0782940322735249 no 326 0.105065425980322 594 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2157 5649910 96.377 µM 1.25117108672309 0.0786065013956067 no 327 0.105436032278578 602 2858091
SGTC_3273 9137859 49.47 µM 1.25093006701983 0.0786435787168432 no 328 0.105479996510023 546 2377234
SGTC_2158 5657123 3.6195 µM 1.25040453732208 0.0787244696542023 no 329 0.105575903975466 572 2858827
SGTC_1944 st076371 56.9 µM 1.24301591464299 0.0798684303474565 no 330 0.106930984492994 565 24208455
SGTC_1931 st074438 57.1 µM 1.24239857728361 0.0799645771742306 no 331 0.107044770149677 550 2787313
SGTC_2275 7947463 200 µM 1.23878014482772 0.0805298883187527 no 332 0.107713464424451 545 1225414
SGTC_2966 9084041 48.03 µM 1.23478066895228 0.0811582370418285 no 333 0.108456071843794 565 17741380
SGTC_1909 st060837 51.5 µM 1.2330328801255 0.0814339870108138 no 334 0.108781748588776 583 678937
SGTC_717 1532-0246 73.2 µM 1.2312416809344 0.0817173184359712 no 335 0.109116243280687 611 9561992
SGTC_3141 9094609 49.47 µM 1.23092960884604 0.081766757841145 no 336 0.109174596221087 557 25236309 YDL196W YDL196W
SGTC_270 tamoxifen 5.46 µM 1.22825503397634 0.0821913971101236 no 337 0.109675622574047 643 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2699 st077704 54.6 µM 1.22688545295709 0.0824094860170375 no 338 0.109932823425229 578 645852
SGTC_1167 k781-0610 148 µM 1.21880314293778 0.0837053749137704 no 339 0.111459459165329 651 4525169
SGTC_674 0498-0004 451 µM 1.21417284510559 0.0844546454971226 no 340 0.11234086383223 586 4231473
SGTC_274 sirtinol 40.1 µM 1.21315231773836 0.084620460995598 no 341 0.11253579526227 607 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1910 st062352 60.4 µM 1.21082177469593 0.0850000434757553 no 342 0.112981859002732 610 2245730
SGTC_1883 5-benzylidenerhodanine 20 µM 1.20905812315341 0.0852881419453789 no 343 0.113320258068069 681 1273210
SGTC_3107 9121808 49.47 µM 1.20881333653808 0.0853281864165153 no 344 0.11336728335805 513 662681
SGTC_1679 SEC14.276 6.7 µM 1.20753451462703 0.0855376170215504 no 345 0.11361318064893 678 1005053 YMR079W SEC14
SGTC_60 0986-0278 202 µM 1.20404688121518 0.0861107373049636 no 346 0.114285729515547 474 3110598
SGTC_2879 9041815 71.43 µM 1.20347415385233 0.0862051271533578 no 347 0.114396443657088 503 4942971
SGTC_606 k015-0008 38.6 µM 1.20345338548588 0.086208551392421 no 348 0.114400459831978 668 1970475
SGTC_2959 9079155 11 µM 1.20342059209775 0.0862139584957237 no 349 0.114406801603107 542 16189457
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.19996960975312 0.0867843890722245 no 350 0.115075571691466 641 5379071
SGTC_996 3970-0799 1.8 µM 1.19885569415942 0.0869691146625351 no 351 0.115292031044406 803 6615648 YGL040C HEM2
SGTC_3177 9107506 49.47 µM 1.19867601080469 0.0869989398449435 no 352 0.115326974732151 572 8897194
SGTC_2412 st077135 33.4 µM 1.19790273433929 0.0871273812284063 no 353 0.115477442576811 633 13258915
SGTC_497 capsazepine 133 µM 1.1978576236011 0.0871348785007112 no 354 0.115486224744976 600 2733484 A calcium channel blocker.
SGTC_3307 9126885 69.2785 µM 1.19714517834336 0.0872533487079766 no 355 0.1156249866778 641 24824909
SGTC_2652 actinonin 100 µM 1.19205534996126 0.0881032204772829 no 356 0.116619771470009 603 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3343 9148379 18.9835 µM 1.19053138074033 0.0883588812056687 no 357 0.116918801829799 628 1955036
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.18963967842273 0.0885087291371135 no 358 0.117094021781036 651 94937 An inhibitor of serotonin biosynthesis.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.1881727783185 0.0887556491254667 no 359 0.117382673020208 681 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2437 5741531 144.16 µM 1.18813893562258 0.0887613518379667 no 360 0.11738933840373 664 2262990
SGTC_535 2293-4129 48.2 µM 1.18813009946216 0.0887628408328992 no 361 0.117391078746507 706 396118 YIL048W NEO1
SGTC_193 1273-0060 1.558 µM 1.18563618021383 0.0891838388576338 no 362 0.117883003874596 530 2847393 YHR072W ERG7
SGTC_2035 5154463 94.595 µM 1.18489107514059 0.0893099077242051 no 363 0.118030258287218 641 2769623
SGTC_618 k072-0232 33.2 µM 1.18312978439651 0.0896084382618029 no 364 0.118378857671352 608 5872756 YGL099W LSG1
SGTC_275 trichlorophene 5.69 µM 1.18217773367296 0.089770115028697 no 365 0.118567592845858 779 62616
SGTC_3003 9075612 71.4286 µM 1.18143142256759 0.0898970047402175 no 366 0.118715690664198 633 6501993
SGTC_2783 7738165 71.43 µM 1.17856174307804 0.0903861567516783 no 367 0.119286366457077 532 17201110
SGTC_2729 fluphenazine 10.66 µM 1.17784681845013 0.0905083263897322 no 368 0.119428839945049 646 3372 An atypical antipsychotic.
SGTC_1651 st011928 86.1 µM 1.1774597488057 0.0905745217807318 no 369 0.119506027055315 638 720198
SGTC_1501 4491-0275 38.4 µM 1.17608447548528 0.0908100072465427 no 370 0.119780560464831 631 5104718
SGTC_1392 3455-1037 33.9 µM 1.17467243041088 0.0910522614391265 no 371 0.120062896671938 643 981132
SGTC_576 1073-0113 22.7 µM 1.17416314329429 0.0911397536035954 no 372 0.120164842832788 821 5439563
SGTC_1739 st037196 92.5 µM 1.17289238258839 0.0913583337464234 no 373 0.120419482319729 692 612214
SGTC_1796 st049173 110.4 µM 1.17240161711423 0.0914428529410325 no 374 0.120517925284416 591 94134
SGTC_3194 9111903 49.47 µM 1.1697685467709 0.0918973078116209 no 375 0.121047062251168 628 17087251
SGTC_168 3970-0862 530.542 µM 1.16924233866011 0.0919883289253508 no 376 0.12115300372025 805 3135186
SGTC_2295 7971645 200 µM 1.16666283610688 0.0924354855785763 no 377 0.121673278344153 646 2978226 YKL099C UTP11
SGTC_1133 3473-0247 50 µM 1.16348035338986 0.0929893825147147 no 378 0.122317332365688 663 711311
SGTC_3094 9117742 49.47 µM 1.16227874601316 0.0931991537555834 no 379 0.122561128530121 686 17149698
SGTC_451 chloral hydrate 100 µM 1.16227197934987 0.0932003360387107 no 380 0.122562502394599 711 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_304 1310-0298 97 µM 1.1606837836897 0.0934781349922054 no 381 0.12288525945807 665 1550234
SGTC_2397 5161689 200 µM 1.15772490019461 0.09399731778548 no 382 0.123488159561808 678 2259942
SGTC_596 1155-0152 116 µM 1.15388869594977 0.0946736040469144 no 383 0.124272902089933 706 280313
SGTC_1338 1486-1223 76 µM 1.15253263404714 0.0949135207372415 no 384 0.124551133782061 699 3444526
SGTC_1844 rapamycin 4 nM 1.14946764448668 0.0954574334923578 no 385 0.125181600505493 764 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_504 lovastatin 124 µM 1.14456926560157 0.0963314569955283 no 386 0.126193814924453 588 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_442 cape 100 µM 1.1444342996416 0.0963556221133558 no 387 0.126221785187173 622 5281787
SGTC_2930 9013230 14.89 µM 1.14357904706344 0.0965088552476311 no 388 0.126399127649784 710 2995857
SGTC_1194 1488-0194 225 µM 1.14238990404538 0.0967222079827302 no 389 0.126645992964398 697 1391452
SGTC_1243 0416-0003 5.65 µM 1.1417054183207 0.0968451734846397 no 390 0.126788243925859 639 2141977
SGTC_745 0469-0705 296 µM 1.13848415035592 0.0974254046133002 no 391 0.127459186718653 759 3486736
SGTC_316 k060-0003 58.6 µM 1.13821012054334 0.0974748816921224 no 392 0.127516376845323 665 6152314
SGTC_676 falcarinol 140 µM 1.13508807502146 0.0980398799465676 no 393 0.128169208753627 696 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2605 digitonin 300 nM 1.1316932152209 0.0986569688421758 no 394 0.128881717487054 778 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1760 st045453 10.4495 µM 1.13148171901718 0.098695506695567 no 395 0.128926196765083 704 3323419 YIL048W NEO1
SGTC_2971 9092186 9.93 µM 1.12878085525229 0.0991886145972149 no 396 0.129495145368265 614 25236400
SGTC_2116 5511452 16.8835 µM 1.12808430110862 0.0993160791174318 no 397 0.129642159241425 692 870744
SGTC_2187 6125751 200 µM 1.12631259096207 0.0996408292467705 no 398 0.130016615080913 692 874498
SGTC_1699 st031318 29.054 µM 1.12456480225956 0.099961954234705 no 399 0.130386747947535 680 5340658
SGTC_1992 st073643 23.3 µM 1.12418459631785 0.100031910270094 no 400 0.130467361380198 656 3161292
SGTC_670 4204-0025 119 µM 1.12236679814935 0.100366870319863 no 401 0.130853257651819 715 719039
SGTC_120 rhodamine 6G 52.259 µM 1.11146880567513 0.102392184363145 no 402 0.133183305024648 809 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1264 0783-0040 158 µM 1.11097284726638 0.10248505662808 no 403 0.133290018524993 651 2855798
SGTC_3084 9116877 49.47 µM 1.10957051982803 0.102747985281736 no 404 0.133592070308559 624 27241325
SGTC_1025 k007-0731 70 µM 1.10756773221406 0.103124346408488 no 405 0.134024272730389 674 6256118
SGTC_3268 9137683 49.47 µM 1.10659656454529 0.103307206950677 no 406 0.134234196647123 669 1953228
SGTC_432 NS 1619 61.3 µM 1.10586809140396 0.103444525131509 no 407 0.13439180879368 631 4552 A K+/calcium channel activator.
SGTC_3226 9131256 49.47 µM 1.10524829464072 0.1035614619398 no 408 0.134526007775081 591 17178073
SGTC_3129 9127257 49.47 µM 1.10131547558731 0.104305701414833 no 409 0.135379689051826 602 837894
SGTC_2226 7298446 200 µM 1.09907074557169 0.10473222373849 no 410 0.135868604517809 657 3283010
SGTC_1792 st045773 43.6 µM 1.09445058917733 0.105614074388008 no 411 0.13687870339332 689 2919270
SGTC_950 1165-0508 94.1 µM 1.08988234151214 0.106491283802857 no 412 0.137882488065935 671 6148369
SGTC_2911 7942208 15.64 µM 1.08855167677309 0.106747788766841 no 413 0.138175818147802 678 1243384
SGTC_420 mitomycin C 81.9 mM 1.08232645038721 0.107953714137788 no 414 0.139553748437146 714 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2916 7875993 68.79 µM 1.07943849418293 0.108516476251157 no 415 0.140196149232683 728 1299250
SGTC_2273 7815444 169.05 µM 1.07818616927025 0.108761165675806 no 416 0.140475341447573 696 2824616
SGTC_699 0375-0592 111 µM 1.0771465506609 0.108964596003372 no 417 0.140707399666876 758 762578
SGTC_3329 9141233 27.5565 µM 1.07549593021999 0.109288147484952 no 418 0.141076376662451 704 4909101 YNL103W MET4
SGTC_3097 9117246 49.47 µM 1.07465235920462 0.109453768922835 no 419 0.141265200282647 722 16423892
SGTC_3352 9151559 45.5865 µM 1.07126602269488 0.110120435120539 no 420 0.142024916349149 706 17159339
SGTC_2293 7624732 200 µM 1.07015903731058 0.11033899717749 no 421 0.142273864474529 656 894453
SGTC_107 0358-0022 2.6945 µM 1.06767738655209 0.110830101677004 no 422 0.142833031195692 592 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2233 sulbentine 40.3845 µM 1.06536150264404 0.111289812702723 no 423 0.143356185441705 803 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1055 3448-0672 86 µM 1.06157622610325 0.112044139415559 no 424 0.144214055600308 724 748378
SGTC_517 1365-0151 113 µM 1.06136826098462 0.112085688201239 no 425 0.144261287531486 727 768657
SGTC_207 4185-0010 4.486 µM 1.05989407388727 0.112380527817972 no 426 0.144596395990557 840 3761753
SGTC_57 miconazole 162.5 nM 1.05833207220383 0.112693534675328 no 427 0.144952038001107 704 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3232 9132874 49.47 µM 1.05564246172502 0.113233959098827 no 428 0.145565796863999 713 3784940
SGTC_2810 7959871 45.46 µM 1.05470685163044 0.113422384327716 no 429 0.145779708607615 792 2974535
SGTC_1588 farnesol 29.9 µM 1.05458427269105 0.113447087413437 no 430 0.145807749897471 752 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2231 micatex 6.853 µM 1.0533079160431 0.113704536983734 no 431 0.146099946016963 717 20737 An antifungal of unknown mechanism.
SGTC_1315 1237-0019 3.69 µM 1.05105257759759 0.114160471220656 no 432 0.146617221292659 789 825140
SGTC_2647 atorvastatin 60.16 µM 1.04928140795887 0.114519438679355 no 433 0.147024310174313 728 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_707 0865-0008 204 µM 1.04804614242012 0.114770268187044 no 434 0.147308674102051 799 723043
SGTC_2352 9027995 87.8 µM 1.04716272656974 0.114949891660556 no 435 0.147512266508154 697 2997347
SGTC_518 1021-0119 62.6 µM 1.04571084396923 0.115245534704248 no 436 0.147847277331846 713 1097762
SGTC_3311 9131146 2.8755 µM 1.0452520252338 0.115339075058791 no 437 0.147953252093982 756 4900406 YPR165W RHO1
SGTC_715 0868-0130 184 µM 1.04473992323682 0.115443542097161 no 438 0.148071593887498 728 2876258
SGTC_3047 9092122 49.47 µM 1.04311261723926 0.115775953155675 no 439 0.148448068875501 722 17173831
SGTC_3179 9107801 49.47 µM 1.04039348896223 0.116332907428694 no 440 0.149078562726498 753 4818259
SGTC_1614 st002383 48.6 µM 1.02984734270014 0.118511032283567 no 441 0.15154083637475 774 1947235
SGTC_1052 3253-3998 198 µM 1.02507682685749 0.119505709587348 no 442 0.152663469346449 805 5450317
SGTC_3347 9188721 44.724 µM 1.02401715682556 0.119727453406518 no 443 0.152913585656002 740 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_421 streptovitacin 30 mM 1.02175289615755 0.120202238725485 no 444 0.153448934273791 817 91467 include heat shock
SGTC_1313 1220-0047 237 µM 1.0206257695084 0.120439076083349 no 445 0.15371588778483 829 3528706
SGTC_2546 rhodinyl acetate 100 µM 1.01950154460451 0.120675630909711 no 446 0.15398246012167 814 6708682
SGTC_3012 9080433 71.4286 µM 1.01862997575743 0.12085924782535 no 447 0.15418933389497 814 17688859
SGTC_86 0417-1630 471.922 µM 1.01016625846079 0.122652562642533 no 448 0.156207820968391 886 3634867
SGTC_929 2805-0021 398 µM 1.0061459047438 0.1235109132161 no 449 0.157172694755702 777 3098024
SGTC_1311 1190-0148 100 µM 1.00443508649839 0.123877448216676 no 450 0.157584472611481 921 1961333
SGTC_667 1498-1044 59 µM 1.00220498778233 0.124356378800994 no 451 0.158122299667072 832 6739982
SGTC_1919 st067113 52.3 µM 1.00184076199852 0.124434721894785 no 452 0.15821025336415 784 1268243
SGTC_258 haloperidol 50.781 µM 0.993919966806293 0.126146984889472 no 453 0.16013091638298 786 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2059 5238311 157 µM 0.993472764821337 0.126244145379884 no 454 0.160239808277146 765 703021
SGTC_2488 5268135 45.7 µM 0.993390960741079 0.126261924029496 no 455 0.160259732478815 869 1270356 YLR208W SEC13
SGTC_2139 5578692 56.4705 µM 0.991320631073405 0.126712454035363 no 456 0.160764521006526 768 650991 YMR113W FOL3
SGTC_2623 humulene 100 µM 0.988404827856501 0.12734886645114 no 457 0.161477212012656 689 6187145 An anti-inflammatory.
SGTC_1527 coumarin 137 µM 0.988376832908012 0.127354987472997 no 458 0.161484064607108 757 323 A hepatotoxic, DNA x-linker.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.987956547799728 0.127446906304026 no 459 0.16158696465136 760 5282362
SGTC_2435 5706476 10.6 µM 0.987036725200302 0.127648237881091 no 460 0.16181231752188 860 5725375
SGTC_2262 9014885 67.46 µM 0.984590282820256 0.128184793015112 no 461 0.16241268233114 752 6457424
SGTC_1271 0832-2808 169 µM 0.983352283359172 0.128456907795253 no 462 0.16271704310069 866 3663794
SGTC_2657 nystatin 74.44 µM 0.983192456696619 0.128492067221397 no 463 0.162756363327315 835 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_814 3342-0569 96 µM 0.98174170215389 0.128811516577163 no 464 0.163113557579309 833 4346283
SGTC_2018 5133068 143 µM 0.978731431050652 0.129476120685825 no 465 0.163856348799834 777 785362
SGTC_55 0767-0285 6.563 µM 0.974896741825144 0.130326174591109 no 466 0.164805741230305 864 3116166
SGTC_155 k072-0202 43.6 µM 0.970390088075471 0.131330111243181 no 467 0.165926043721818 824 5857737
SGTC_752 1896-0090 130 µM 0.968671901973864 0.131714269955225 no 468 0.166354458016449 851 772567
SGTC_1289 0976-0073 69.1 µM 0.967681564639351 0.131936045341862 no 469 0.16660171395727 874 3391136
SGTC_1221 2958-7315 257 µM 0.966493132815781 0.132202521679245 no 470 0.166898740770416 801 4562705
SGTC_2765 myclobutanil 7.74 µM 0.965055662059226 0.132525334340111 no 471 0.167258466470506 819 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_894 0960-0238 55.9 µM 0.964279623964562 0.132699834697056 no 472 0.167452876842475 871 6741907 YDL195W SEC31
SGTC_1484 3473-2379 286 µM 0.963989491769031 0.132765114609794 no 473 0.167525597130419 993 671917
SGTC_2555 cholic acid 100 µM 0.95814141245688 0.134085652810813 no 474 0.168995727731318 836 6708657 Influences liver metabolism.
SGTC_2374 9071832 200 µM 0.957812267841887 0.134160243318731 no 475 0.169078715967643 838 17381698
SGTC_1143 3454-2408 5.08 µM 0.956668909076869 0.134419571884247 no 476 0.169367197821244 818 X1143
SGTC_1104 tacrolimus 29.8 µM 0.955885223477865 0.134597520596206 no 477 0.1695651125884 875 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1446 4239-0190 62 µM 0.955679457991208 0.13464426982427 no 478 0.169617101924951 869 1340085
SGTC_1248 0469-0687 58.6 µM 0.955448695229937 0.13469671160458 no 479 0.169675419312387 857 4017482
SGTC_1472 k841-0093 193 µM 0.95344589430811 0.135152445035167 no 480 0.170182098771648 890 X1472
SGTC_385 1494-0393 12.4 µM 0.952905448835838 0.13527560327436 no 481 0.170318989538202 869 3090647
SGTC_1529 apigenin 74 µM 0.951583269748494 0.135577229439913 no 482 0.170654184815169 857 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_156 3474-0145 5.642 µM 0.947322572159957 0.136552347450229 no 483 0.17173721611404 851 2265471
SGTC_182 3448-4371 550.524 µM 0.944431548125998 0.137216722209094 no 484 0.172474583147997 912 3491403
SGTC_3184 9108758 49.47 µM 0.942999673615734 0.137546591848787 no 485 0.172840534933649 857 902885
SGTC_2888 9058547 12.99 µM 0.94260560187125 0.137637471467108 no 486 0.172941336716705 761 16476514
SGTC_875 0709-0210 25.7 µM 0.939503400898955 0.138354322654913 no 487 0.173736173479091 932 6251364
SGTC_2146 5545642 200 µM 0.939477735713509 0.138360263915681 no 488 0.173742759014403 864 825326
SGTC_908 3448-7491 47.7 µM 0.939369924395326 0.138385223170607 no 489 0.173770424497702 919 1203031
SGTC_1604 st002052 72.4 µM 0.937816645150488 0.138745161392967 no 490 0.174169322756799 854 6254834 YHR062C RPP1
SGTC_492 tmb-8 126 µM 0.932722451683443 0.139930100556133 no 491 0.175481644803041 728 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_954 1189-0853 2.85 µM 0.93087984345567 0.140360390806199 no 492 0.175957861083059 918 2828194
SGTC_216 k038-0035 28.382 µM 0.930877536248124 0.140360930153406 no 493 0.175958457886084 834 4444231 YPR107C YTH1
SGTC_3180 9109287 49.47 µM 0.930860604592177 0.140364888245828 no 494 0.17596283761949 821 18891271
SGTC_1466 k213-0079 57.5 µM 0.930448474322861 0.140461254808345 no 495 0.176069465179711 892 3657981
SGTC_2320 7373003 200 µM 0.930140619053425 0.140533268519559 no 496 0.176149141088192 869 5415828
SGTC_971 1315-0384 26.7 µM 0.929923217297555 0.140584138380783 no 497 0.176205420502951 843 6769120
SGTC_29 0299-0004 12.984 µM 0.929228004700888 0.140746895137786 no 498 0.176385468551031 781 16871 A napthoquinone isolated from Swertia calycina.
SGTC_478 N-arachidonylglycine 10 µM 0.92836521819739 0.140949060490297 no 499 0.176609077141964 775 5283389
SGTC_2227 7312221 64.1025 µM 0.927622933240056 0.141123147862655 no 500 0.176801598706362 902 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_495 decylubiquinone 155 µM 0.927127255975131 0.141239479726941 no 501 0.176930233099874 818 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2083 5306046 65.942 µM 0.926465946844516 0.141394785391568 no 502 0.177101943080704 863 539837
SGTC_2775 cyproheptadine 69.59 µM 0.924692708980208 0.141811793922198 no 503 0.177562886526479 905 2913 A selective serotonin reuptake inhibitor.
SGTC_2958 9077254 16.72 µM 0.924275166199421 0.14191010758442 no 504 0.17767153451556 844 16457351
SGTC_2754 granisetron 64.02 µM 0.922546492199384 0.142317628146354 no 505 0.178121795593777 868 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2570 licareol 100 µM 0.919749619820116 0.142978642968105 no 506 0.17885180806022 824 443158
SGTC_1682 st012968 530 nM 0.919665786995934 0.142998488049687 no 507 0.178873718318996 795 24207270
SGTC_3199 9111318 49.47 µM 0.919102934709131 0.143131775816895 no 508 0.179020867202761 860 8548020
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.916543335323125 0.143738967122306 no 509 0.179690994577304 926 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2203 7227154 166.4 µM 0.915899966893955 0.143891860711837 no 510 0.179859682087615 916 896304
SGTC_1420 4'-methoxyflavone 42 µM 0.914414406507277 0.144245316384248 no 511 0.180249567335052 908 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1990 st072050 59.8 µM 0.914272614346149 0.144279083210803 no 512 0.180286808389633 903 17233948
SGTC_1306 1185-0270 9.02 µM 0.912617623228366 0.144673601984267 no 513 0.180721841166024 928 1548076
SGTC_1864 st057645 30.4 µM 0.911928464428074 0.144838098577594 no 514 0.180903188131762 894 688666
SGTC_2952 9073731 13.78 µM 0.911507488922686 0.14493864394249 no 515 0.181014020767916 937 16457353
SGTC_3220 9131269 49.47 µM 0.910439631625226 0.145193900636519 no 516 0.181295352478807 888 17722206
SGTC_381 3461-2219 42.7 µM 0.906907908878338 0.146040264301803 no 517 0.182227749233901 925 2883159
SGTC_2653 dihydrofissinolide 100 µM 0.903886091586485 0.146767057310648 no 518 0.183027902439119 914 6857746
SGTC_2324 6149169 200 µM 0.903784398888279 0.14679155808388 no 519 0.183054867928963 867 2888231
SGTC_928 2764-0428 58.7 µM 0.898663397639464 0.148028907097652 no 520 0.184415989412975 931 662578
SGTC_1902 st060212 70.5 µM 0.897253940990938 0.148370685022803 no 521 0.18479171389654 961 688944
SGTC_1263 0774-1208 64.8 µM 0.894220427429869 0.149108068270785 no 522 0.185601982382773 981 906585
SGTC_577 r071-0003 38.6 µM 0.893775420729403 0.149216445545589 no 523 0.185721031321727 1040 4568517 YMR134W ERG29
SGTC_948 3448-0295 75.3 µM 0.893685307699137 0.149238398145293 no 524 0.185745144276993 940 678569
SGTC_457 grayanotoxin iii 135 µM 0.889970066924447 0.150145352171927 no 525 0.186740979498571 939 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_109 0132-0036 33.701 µM 0.889137427071183 0.150349116772991 no 526 0.186964613261308 806 67274 A color developer.
SGTC_69 0096-0274 206.684 µM 0.887938212595298 0.150642913604688 no 527 0.187286994154165 983 6741392
SGTC_2247 cerulenin 830 nM 0.887818470312323 0.150672270373805 no 528 0.187319202940519 918 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1193 1488-0126 41.5 µM 0.8864953404539 0.15099691080507 no 529 0.187675331959367 949 1384710
SGTC_860 0443-0016 25.1 µM 0.884576587899324 0.151468518411532 no 530 0.188192519214461 995 5337942
SGTC_1959 st077091 55.8 µM 0.881426672088534 0.152244853418975 no 531 0.189043463316308 977 821356 YKL052C ASK1
SGTC_572 0960-0087 17.7 µM 0.878714234541224 0.152915479772969 no 532 0.189778119321732 1019 6796365
SGTC_2239 6685329 187.64 µM 0.878586592623712 0.152947086296631 no 533 0.189812733972191 903 805680
SGTC_3121 9125696 49.47 µM 0.877555583028672 0.153202542315731 no 534 0.190092471238914 952 1235365
SGTC_135 0933-0004 26.348 µM 0.876733972592281 0.153406317265576 no 535 0.190315574861932 875 21230617 YGL099W LSG1
SGTC_2835 9006588 71.43 µM 0.875500662157162 0.153712538497818 no 536 0.190650775046368 861 2345538
SGTC_1976 st070609 63.5 µM 0.871041590958541 0.154823064996454 no 537 0.19186572214156 949 682556
SGTC_493 zm226600 134 µM 0.870363817471818 0.15499232657743 no 538 0.192050806739061 946 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1652 st011932 78 µM 0.869715238579675 0.155154411717584 no 539 0.192228021214026 929 1551076
SGTC_2619 obliquin 87.91 µM 0.867870288153026 0.155616091524439 no 540 0.192732673013906 988 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2818 7996756 12.99 µM 0.866627349844712 0.155927634349359 no 541 0.193073111568468 892 2241621
SGTC_1459 k035-0031 35.7 µM 0.865663394606249 0.156169532870829 no 542 0.193337389789196 834 3877128 YMR208W ERG12
SGTC_1882 5615643 20 µM 0.865127873357328 0.156304025349089 no 543 0.193484303767188 916 2253075
SGTC_593 1203-0218 61.7 µM 0.863683016261649 0.156667271769458 no 544 0.193881022980115 998 3666956
SGTC_419 nsc-638432 893 µM 0.863082296112043 0.156818460109757 no 545 0.194046110514112 951 368090
SGTC_2476 5806916 10.51 µM 0.861592993267099 0.157193699533968 no 546 0.194455764037091 925 2870194
SGTC_2183 6420625 130.508 µM 0.860745578774261 0.157407474394229 no 547 0.194689092023385 989 2897619
SGTC_862 0452-0056 10.2 µM 0.85880181677818 0.157898543246822 no 548 0.195224932537002 940 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2024 5144227 134 µM 0.857836541554492 0.158142782235152 no 549 0.195491364474366 991 3475211
SGTC_3068 9116768 49.47 µM 0.857608305838887 0.158200567856763 no 550 0.195554393574299 918 41904888
SGTC_2636 apigenin dimethyl ether 100 µM 0.853206220493943 0.159317815983469 no 551 0.196772477203386 950 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_951 1171-0579 82.7 µM 0.847121719880517 0.160870546045255 no 552 0.19846363994589 1004 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2427 5545055 42.75 µM 0.846754986774081 0.160964448876627 no 553 0.198565851377941 1020 5372858
SGTC_2002 4023503 131 µM 0.846513996828655 0.161026174365967 no 554 0.198633034475882 1072 4736863 YCR052W RSC6
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.846173077190867 0.161113521532633 no 555 0.198728099351265 973 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1692 fluoroquinolonic acid 71 µM 0.842637680639443 0.162021149304364 no 556 0.199715555259636 966 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2156 5649887 115 µM 0.839746041629033 0.162765978969447 no 557 0.200525396511644 1061 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1974 st069448 26.9 µM 0.837429975367653 0.163364155944423 no 558 0.201175461230249 990 6323587 YNR016C ACC1
SGTC_2734 clemastine 41.6 µM 0.835635326993076 0.163828645593645 no 559 0.201680044246802 915 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_266 formosanin C 406 nM 0.833791876824502 0.16430665760386 no 560 0.202199136807554 994 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1840 st055363 71 µM 0.832805503275753 0.164562798160181 no 561 0.202477215248767 920 676033
SGTC_2684 capsaicin 100 µM 0.829496137219339 0.165424060650005 no 562 0.203411860838475 980 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2893 9048488 25.97 µM 0.828610733174531 0.165654980622342 no 563 0.203662356285799 999 6467338
SGTC_2943 9068529 45.32 µM 0.826606618756849 0.166178438080719 no 564 0.204230032328712 1097 3270634
SGTC_303 1348-1668 34.2 µM 0.825585060503217 0.166445670993238 no 565 0.204519756322734 982 5380509
SGTC_141 0443-0274 32.331 µM 0.822838435317829 0.167165545022336 no 566 0.205299938220698 1160 1627241
SGTC_2493 resveratrol 26.09 µM 0.82253649834043 0.167244803170739 no 567 0.205385811476807 953 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2015 5119600 184 µM 0.819972072088906 0.167918938738136 no 568 0.206116014147042 1016 2828786
SGTC_547 1120-0019 610 nM 0.815720646899815 0.169040400025752 no 569 0.207329963713973 985 3676939
SGTC_277 nystatin 15.5 µM 0.814184610390765 0.169446763312676 no 570 0.207769600202339 1065 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_113 0099-0221 2.5 µM 0.814117922135451 0.169464420087793 no 571 0.207788699836476 981 89219
SGTC_858 0438-0351 2.77 µM 0.812718107768607 0.16983531564669 no 572 0.208189848430507 1040 2799119
SGTC_1107 amlodipine 47 µM 0.811120553127272 0.17025924006778 no 573 0.208648221915365 968 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1393 3470-5649 58.2 µM 0.810217907545562 0.170499064054935 no 574 0.208907473547119 919 4108395
SGTC_130 0136-0219 337.655 µM 0.807235353346398 0.171293036529135 no 575 0.209765450539197 1012 234244
SGTC_2700 st077718 96.8 µM 0.80703721490208 0.17134586568225 no 576 0.209822521360508 972 904970
SGTC_3165 9101544 49.47 µM 0.805613125341348 0.171725873488659 no 577 0.210232977583888 1030 5002184
SGTC_3164 9100705 49.47 µM 0.805103965554926 0.171861869568242 no 578 0.210379843811934 1007 17174235
SGTC_3122 9126309 49.47 µM 0.805059329448494 0.171873795106518 no 579 0.210392721887925 1103 17591206
SGTC_2698 st077697 67.5 µM 0.804796950901205 0.171943906109893 no 580 0.210468430741398 974 3154499
SGTC_1080 nisoldipine 24.4 µM 0.803312021798532 0.172341042761839 no 581 0.210897205581799 1056 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1867 st057372 64 µM 0.80307818307097 0.172403635015376 no 582 0.210964773410231 1064 688837
SGTC_2100 5377183 190 µM 0.801389840492436 0.172855988528509 no 583 0.21145299741347 1087 2844202
SGTC_3321 9137793 26.8275 µM 0.799935534526084 0.173246242986692 no 584 0.21187407416819 1063 4904192
SGTC_1866 st057638 64 µM 0.798793165543364 0.17355318411082 no 585 0.212205177068902 1021 688802
SGTC_2486 5283202 22.39 µM 0.798532923710931 0.173623156402422 no 586 0.212280647539346 979 1377751
SGTC_588 3970-1144 52.9 µM 0.798174277694094 0.173719616441775 no 587 0.212384681054206 1016 1888707
SGTC_660 4031-1742 102 µM 0.797106647145481 0.174006963955037 no 588 0.212694548101964 1004 6738706
SGTC_97 0535-0701 19.132 µM 0.79344132025026 0.174995766575596 no 589 0.213760372339328 1014 2832013 YGL099W LSG1
SGTC_151 3013-0144 2.285 µM 0.791310999247341 0.175572102485407 no 590 0.214381265709226 1028 906558 YHR107C CDC12
SGTC_3178 9107506 49.47 µM 0.789988726455267 0.175930433785225 no 591 0.214767176095967 1028 8897194
SGTC_2556 citropten 84.59 µM 0.789194222492053 0.176145964157387 no 592 0.21499924912046 1091 2775 A potential DNA crosslinker.
SGTC_1288 0973-0013 65.5 µM 0.788883291619218 0.176230357926094 no 593 0.215090111041125 1075 4315430
SGTC_2038 4100038 30.985 µM 0.784336081376857 0.177467497507864 no 594 0.21642146661315 1017 3596803
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.783029972647094 0.177823855840313 no 595 0.216804755683112 1093 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1349 flufenamic acid 69 µM 0.782542881596441 0.177956869096244 no 596 0.216947797245723 1005 3371 A non-steroidal anti-inflammatory.
SGTC_1720 st037298 9.481 µM 0.781275298460353 0.178303310613241 no 597 0.217320297549065 1032 597396
SGTC_2369 9071472 200 µM 0.779955977083753 0.178664343690131 no 598 0.217708393973852 1064 17296037
SGTC_2384 9036245 200 µM 0.779270786428041 0.178852027999923 no 599 0.217910109834288 1082 6462766
SGTC_1644 st010134 20.9 µM 0.77908878230047 0.178901902595476 no 600 0.217963708826391 1056 3818134
SGTC_645 0845-0943 5.41 µM 0.777584055324057 0.17931457823843 no 601 0.218407131924454 1026 1885106
SGTC_1082 camptothecin 424.86 nM 0.7767027175278 0.179556565379086 no 602 0.218667091595746 1071 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_49 0717-0965 32.132 µM 0.776578062387804 0.179590808249679 no 603 0.21870387428609 1174 5889349 YGL099W LSG1
SGTC_1020 4335-0961 93.3 µM 0.776539314923411 0.179601453046422 no 604 0.218715308442898 985 669075
SGTC_400 oxethazaine 37.5 µM 0.775556802748109 0.179871503646469 no 605 0.219005357157952 1027 4621 A local anesthetic.
SGTC_977 1348-1378 135 µM 0.77495064075484 0.180038238809282 no 606 0.219184413328778 1125 X977
SGTC_1489 4065-0444 182 µM 0.774487572673734 0.180165678920166 no 607 0.219321257207243 1070 2877968
SGTC_2101 5377231 179.231 µM 0.774365631786231 0.180199247462915 no 608 0.219357300816878 1065 2844213
SGTC_202 3594-0513 34.79 µM 0.773919478610181 0.180322100360811 no 609 0.219489204957677 1061 708429
SGTC_1656 st012921 11 µM 0.770609145027083 0.181235275942776 no 610 0.220469319497828 999 6732821
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.769717035298331 0.181481864391552 no 611 0.220733881331557 1061 688667
SGTC_3039 9090270 49.47 µM 0.769554334350227 0.181526859266807 no 612 0.220782151115043 1085 17173750
SGTC_306 1672-3436 11.6 µM 0.768841467382845 0.181724084617953 no 613 0.220993714273255 1110 6797378
SGTC_1942 st076330 65.2 µM 0.76702756136826 0.182226533235757 no 614 0.221532564424408 1130 24208414
SGTC_800 3448-7362 155 µM 0.766997976277327 0.182234735440803 no 615 0.221541359374668 1209 15991913
SGTC_2455 5377712 9.75 µM 0.766747994829995 0.182304049799374 no 616 0.221615680934488 1040 2243908
SGTC_465 cgp-37157 41 µM 0.765679520811764 0.182600499806692 no 617 0.221933507691217 1006 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2160 5660466 132.927 µM 0.764943058027055 0.182805007868372 no 618 0.222152726306953 1035 2859134
SGTC_1223 0764-0573 147 µM 0.76452890355479 0.182920077044673 no 619 0.222276059543143 1143 1609797
SGTC_1678 st019265 80.2 µM 0.763131818487891 0.183308578167269 no 620 0.222692392897796 1125 5367020
SGTC_411 enrofloxacin 100 µM 0.763115347503893 0.183313161481597 no 621 0.222697303924147 1139 71188 A bacterial gyrase inhibitor.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.760479770478116 0.184047473217576 no 622 0.223483928424765 1173 65057 A dermal irritant. YDR527W RBA50
SGTC_2482 5981709 142.65 µM 0.759958387796341 0.184192955019964 no 623 0.223639729373673 1061 877755
SGTC_1704 st028805 70.8 µM 0.75773107189699 0.184815250267166 no 624 0.224305996862006 1081 2876101
SGTC_2829 7992743 58.44 µM 0.756800489187256 0.18507563464142 no 625 0.224584699856728 1103 16462845
SGTC_1485 3909-9022 254 µM 0.75662099929139 0.185125883533198 no 626 0.22463847841308 1146 714516
SGTC_3333 9141820 12.094 µM 0.756365321407394 0.185197476179061 no 627 0.224715096939086 1036 1939433
SGTC_1820 st053765 18.6 µM 0.756184295666793 0.185248175791629 no 628 0.224769353553388 1104 3690829
SGTC_1554 st069299 38.7 µM 0.755800888346598 0.185355584570706 no 629 0.224884292028694 1115 24207999
SGTC_2566 crystal violet carbinol 226 nM 0.755671699354759 0.185391784636555 no 630 0.224923028020118 1057 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2719 novobiocin 32.65 µM 0.75549727100697 0.185440668191717 no 631 0.224975334567493 1089 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3227 9130768 49.47 µM 0.754285533643223 0.185780478472966 no 632 0.225338893486684 1113 17720899
SGTC_2985 9022375 71.43 µM 0.75359746788277 0.185973606144743 no 633 0.225545482624712 1157 4939335
SGTC_76 0433-0009 400.328 µM 0.752629214548706 0.186245588170786 no 634 0.22583637849216 987 2841569
SGTC_402 epigallocatechin gallate 10 µM 0.752376109201516 0.18631672599193 no 635 0.225912454818608 1087 65064 An antioxidant.
SGTC_1762 st045503 25.4615 µM 0.748285104791763 0.187468878236863 no 636 0.227144103507118 1156 4645554
SGTC_328 k915-0120 63.5 µM 0.745747191353673 0.188185840701528 no 637 0.227910072988024 1098 6624543
SGTC_1815 st051655 58.2 µM 0.744551162815476 0.188524305469215 no 638 0.22827155041169 1106 5984156
SGTC_912 3474-0017 2.18 µM 0.743116181473956 0.188930886633985 no 639 0.228705671841973 1139 3360550
SGTC_1640 st009078 66.4 µM 0.743057441307123 0.188947541310291 no 640 0.228723452233101 1082 690618
SGTC_1381 2324-0066 62.1 µM 0.742543584029307 0.18909327449829 no 641 0.228879027666826 1078 10885928
SGTC_591 4299-0174 154 µM 0.741304822324857 0.189444879681402 no 642 0.229254319224351 1090 5509088
SGTC_2557 derrustone 83.84 µM 0.740841504337796 0.189576489328807 no 643 0.229394773270488 1144 629853 An antioxidant.
SGTC_3202 9113761 49.47 µM 0.740803197298919 0.189587373305358 no 644 0.229406388141386 1146 4798415
SGTC_741 4582-0002 126 µM 0.740585684263809 0.18964918142323 no 645 0.229472345346138 1102 2912688
SGTC_284 0988-0104 32.6 µM 0.74017476579463 0.189765981108348 no 646 0.229596978524239 1156 4666532
SGTC_1837 st055472 66.5 µM 0.740055667105743 0.189799842050497 no 647 0.22963310870931 1161 676091
SGTC_2152 5568786 200 µM 0.738509952047155 0.190239641177729 no 648 0.2301023109014 1118 5399883
SGTC_1136 pergolide 1.05886 µM 0.735989042200713 0.190958252326144 no 649 0.230868683215151 1086 47811 A dopamine receptor agonist.
SGTC_907 3448-6986 75.5 µM 0.734987480170094 0.191244219398746 no 650 0.231173559492825 1162 590582
SGTC_1391 3442-0225 151 µM 0.734922558826547 0.191262764866195 no 651 0.231193329351016 1081 5227075
SGTC_351 caspofungin 25 nM 0.734754951798113 0.191310648680634 no 652 0.231244373431929 1205 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2279 7948423 32.93 µM 0.734648929757944 0.191340942013713 no 653 0.231276665285736 1117 1247112
SGTC_1452 4194-0072 190 µM 0.734243126035057 0.191456918151655 no 654 0.231400286922105 1169 1343545
SGTC_1643 st009866 20.2 µM 0.734140244209247 0.191486327969684 no 655 0.231431634084794 1139 3156273 YOR207C RET1
SGTC_1686 st019653 115.5 µM 0.734070682090133 0.191506214578448 no 656 0.231452830375608 1145 97252
SGTC_40 0327-0103 19.753 µM 0.734051485383981 0.191511702808045 no 657 0.231458679999336 1080 409036
SGTC_1112 tnp00069 1.16933 µM 0.730077281728345 0.192649979255637 no 658 0.232671473552684 1179 145826
SGTC_2357 9067248 200 µM 0.728137675556991 0.193207012155216 no 659 0.233264656440531 1131 9150235
SGTC_2996 9066192 71.4286 µM 0.728066114997324 0.193227582323384 no 660 0.233286557595228 1162 6472854
SGTC_2071 5230951 39.92 µM 0.727304380747584 0.193446626576204 no 661 0.233519757556096 1202 1799272
SGTC_3281 9140613 49.47 µM 0.726062528770139 0.193804058089026 no 662 0.233900219474536 1106 16013766
SGTC_1004 4084-0029 199 µM 0.725711228809872 0.193905242722541 no 663 0.234007908322344 1163 716894 YLR208W SEC13
SGTC_2986 9022445 71.43 µM 0.724664054953351 0.194207050304338 no 664 0.234329075932322 1125 6459286
SGTC_1697 st025554 27.742 µM 0.722590307162834 0.194805572016892 no 665 0.234965812493885 1156 1269519
SGTC_1362 1611-0397 101 µM 0.720506343438209 0.195408171117699 no 666 0.235606647730868 1166 27816
SGTC_1176 0848-0131 83.3 µM 0.719924356143219 0.195576660652316 no 667 0.235785785470045 1221 6769040
SGTC_368 fentichlor 4.58 µM 0.719558700308739 0.195682565772043 no 668 0.23589837402627 1124 7329 A pesticide.
SGTC_2695 st077686 51.995 µM 0.719301570860144 0.195757059173072 no 669 0.235977564123387 1160 2876092
SGTC_3024 9090631 49.47 µM 0.71717192727221 0.1963747031838 no 670 0.23663400936228 1130 25236383
SGTC_1290 0986-0249 10.2 µM 0.716456184731119 0.196582549357432 no 671 0.236854856501353 1136 53329
SGTC_1177 0983-0204 23.6 µM 0.715850192980142 0.196758628888159 no 672 0.23704192785944 1193 766818
SGTC_550 4123-0385 25.7 µM 0.714982380559114 0.197010950408812 no 673 0.237309965335368 1173 5731123
SGTC_1170 0310-0127 64.8 µM 0.713442100324983 0.197459277887614 no 674 0.237786114656663 1153 774975
SGTC_1376 2910-0861 41.3 µM 0.712898742342023 0.197617579510486 no 675 0.237954208734086 1170 1112859
SGTC_1146 3579-1023 7 µM 0.712004979677154 0.197878134653261 no 676 0.238230846207194 1199 X1146
SGTC_976 1348-1067 47.6 µM 0.710746362159064 0.19824540621447 no 677 0.238620712152992 1227 5310671 YGL099W LSG1
SGTC_1270 0831-1170 17.3 µM 0.709923754270484 0.198485669944614 no 678 0.238875709502477 1174 6764716
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.709707311246033 0.198548916860592 no 679 0.238942828677221 1204 4213774
SGTC_1999 st074831 12.5 µM 0.708897520501836 0.198785653989756 no 680 0.239194036950337 1147 17112523
SGTC_2387 9077560 195.08 µM 0.708303184157684 0.19895951264169 no 681 0.239378500083796 1169 5303272
SGTC_2580 diallyl disulphide 81.36 µM 0.7076682605748 0.199145345305527 no 682 0.239575646013931 1164 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_721 1187-1332 279 µM 0.705327514449135 0.199831349559241 no 683 0.240303220757865 1112 25730
SGTC_2199 6590217 200 µM 0.704720578789354 0.200009456436281 no 684 0.240492071087434 1127 703109
SGTC_530 4358-1714 28 µM 0.703109922405228 0.200482570304166 no 685 0.240993624515952 1179 1564641
SGTC_893 0958-0369 48.9 µM 0.702693065707229 0.200605127104923 no 686 0.241123525009201 1192 6819948
SGTC_2205 7238770 200 µM 0.702006378775299 0.200807112654331 no 687 0.241337592721133 1201 279867
SGTC_1496 4469-0713 57.4 µM 0.701862620960022 0.20084941374709 no 688 0.241382420835286 1169 746691
SGTC_1115 galangin 695.678 nM 0.701444704368067 0.200972417102871 no 689 0.241512765786067 1241 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_422 cantharidin 155 µM 0.700763210263427 0.201173094850794 no 690 0.241725400487791 1180 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1814 st052110 31.539 µM 0.69864085809766 0.201798827575911 no 691 0.24238825144707 1170 674163
SGTC_2089 5281248 129.67 µM 0.698534274020088 0.201830282444595 no 692 0.242421565632904 1193 2737878
SGTC_65 0798-0905 34.986 µM 0.698533392870501 0.201830542499842 no 693 0.242421841057561 1276 3602145
SGTC_110 0850-0284 111.64 µM 0.69423144660808 0.203102573838879 no 694 0.243768537308842 1070 3906265
SGTC_3350 9150499 3.57 µM 0.692666416245812 0.203566518391473 no 695 0.244259459775934 1190 4910996 YPR165W RHO1
SGTC_1292 0kpi-0043 232 µM 0.69210305787366 0.203733677436742 no 696 0.244436305743459 1186 3333905
SGTC_3035 9091303 49.47 µM 0.691928776485544 0.203785406578019 no 697 0.244491029045587 1227 25237002
SGTC_1050 3232-1156 69.3 µM 0.686702561091211 0.20534025483421 no 698 0.246135091369818 1171 700529
SGTC_541 4513-1321 94 µM 0.686303844591178 0.205459165347831 no 699 0.246260762545344 1172 747515
SGTC_2686 alizarin 95.37 µM 0.686139390111605 0.205508223048752 no 700 0.246312606857164 1185 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3158 9100007 49.47 µM 0.685927312734227 0.205571497195896 no 701 0.246379472935074 1213 19297233
SGTC_794 k038-0031 316 µM 0.685709151941422 0.205636598421223 no 702 0.246448267209053 1246 6624242
SGTC_2348 9022543 33.42 µM 0.684545634864933 0.205984009445111 no 703 0.24681534152515 1207 3162678 YDL140C RPO21
SGTC_621 3584-0052 32.1 µM 0.684455827292823 0.206010839278781 no 704 0.246843686794063 1221 2273927
SGTC_1328 1441-0025 69.2 µM 0.680099948203815 0.20731463597377 no 705 0.248220588636433 1168 4562601
SGTC_1327 1436-0082 2.18 µM 0.679721185348536 0.207428236939755 no 706 0.248340509561975 1198 15992205
SGTC_2283 7944793 200 µM 0.679101202539251 0.207614265521323 no 707 0.248536870291345 1207 2970533
SGTC_863 0466-0191 129 µM 0.677754277812746 0.208018755801616 no 708 0.248963752714285 1233 765160 YPR165W RHO1
SGTC_3197 9113331 49.47 µM 0.676913964348874 0.208271342896238 no 709 0.249230271755052 1259 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2847 9005661 71.43 µM 0.675567448914531 0.208676464665439 no 710 0.249657657100188 1139 2991449
SGTC_1816 st051957 91.6 µM 0.673806090297062 0.209207099541894 no 711 0.250217301179949 1235 674121
SGTC_916 4466-0038 42 nM 0.67379978341533 0.209209001007778 no 712 0.250219306287386 1278 5722064 YGL116W CDC20
SGTC_552 k242-0005 476 µM 0.673269827401379 0.209368814133993 no 713 0.250387822321617 1249 4088318
SGTC_1683 st010134 710 nM 0.673056628664189 0.209433126439058 no 714 0.250455632470286 1249 3818134
SGTC_758 0868-0029 16 µM 0.672775805433101 0.209517855696151 no 715 0.250544966165965 1243 762687
SGTC_2505 galangin 7.89 µM 0.671161104683955 0.210005430185848 no 716 0.2510589519095 1163 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_911 3456-4043 236 µM 0.670314823738459 0.210261238955212 no 717 0.251328559661791 1294 914281
SGTC_3203 9113543 49.47 µM 0.669513042866952 0.210503765230206 no 718 0.251584131734799 1263 17018012
SGTC_3231 9132313 49.47 µM 0.667303265657175 0.211173037791539 no 719 0.252289220429697 1242 4905967
SGTC_1114 scopoletin 1.73284 µM 0.666852406755659 0.2113097418812 no 720 0.252433206919724 1255 5280460 A coumarin with genotoxic properties.
SGTC_1808 st050063 61.5 µM 0.664879122529425 0.211908667391811 no 721 0.253063905032737 1238 4011993
SGTC_3303 9125618 40.5795 µM 0.664333505261675 0.212074446646374 no 722 0.253238440581505 1263 22695467
SGTC_881 0833-0569 170 µM 0.664108073347598 0.212142963559947 no 723 0.25331057166136 1222 5418700
SGTC_751 0833-0568 350 µM 0.663450672454783 0.212342845359154 no 724 0.253520980807067 1278 6954252
SGTC_501 nsc-95397 161 µM 0.663057515258488 0.212462436813379 no 725 0.25364685941194 1276 262093
SGTC_2200 6600604 21.907 µM 0.663007035797943 0.212477794620962 no 726 0.253663023986613 1214 2904777
SGTC_3290 9121031 71.43 µM 0.662721945748346 0.212564542232357 no 727 0.253754325913482 1227 17014854
SGTC_3289 9119912 71.43 µM 0.661960159888387 0.212796440992524 no 728 0.253998377374927 1264 17014829
SGTC_1156 4092-0367 4.88 µM 0.661337720563235 0.212986030215041 no 729 0.254197878116129 1241 1357585
SGTC_710 3448-4187 58 µM 0.660477165409655 0.213248309562384 no 730 0.254473833674876 1274 3946412
SGTC_1207 2099-0101 141 µM 0.658846396197943 0.213745850463601 no 731 0.254997205240947 1264 5837381
SGTC_1748 st037455 53.6035 µM 0.658603417242457 0.2138200401634 no 732 0.255075233967708 1251 580690
SGTC_1933 st074711 15.9 µM 0.657041191062977 0.214297398719629 no 733 0.255577215553991 1247 17250958
SGTC_3293 9120939 62.045 µM 0.655770167979114 0.214686233317484 no 734 0.255986006811708 1267 934087
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.654358250101615 0.215118651133871 no 735 0.256440512812386 1282 6708739 YPR165W RHO1
SGTC_2119 5528445 120.635 µM 0.652659438311244 0.215639603447668 no 736 0.256987928706591 1283 791935
SGTC_2689 tacrolimus 100 µM 0.652310833173336 0.215746595992601 no 737 0.257100336459302 1274 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_325 2810-4341 181 µM 0.649976119968887 0.216463949906598 no 738 0.257853823455719 1265 774970
SGTC_1851 st056236 18.9 µM 0.649301928945914 0.216671355480727 no 739 0.258071619601114 1282 5393171
SGTC_449 xestospongin c 11.1929 µM 0.644300560476136 0.218213542408477 no 740 0.259690276133913 1250 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_346 4513-0042 7.16 µM 0.643330276995784 0.218513463132174 no 741 0.260004907149682 1283 2827372
SGTC_3239 9133757 49.47 µM 0.642128695735314 0.218885208234632 no 742 0.260394812695887 1282 17036923
SGTC_1648 st011736 69.8 µM 0.64132366600852 0.219134471665693 no 743 0.2606562081498 1317 2855514
SGTC_490 phenamil 164 µM 0.638434112738127 0.220030514582787 no 744 0.261595565485717 1234 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1204 4049-0315 18.3 µM 0.637533543194305 0.220310207902074 no 745 0.261888684041384 1355 588402
SGTC_2096 5468907 200 µM 0.635633319366247 0.220901035977279 no 746 0.262507723556259 1291 759785
SGTC_3244 9134489 49.47 µM 0.633197428138807 0.221659741760161 no 747 0.263302362507057 1237 16584271
SGTC_2865 9030313 51.95 µM 0.631999476879786 0.222033412562855 no 748 0.263693609525968 1238 42562754
SGTC_1007 4101-0031 70 µM 0.631714637164505 0.22212231404811 no 749 0.263786680876968 1276 1146276
SGTC_2277 7947813 106.88 µM 0.630986276504506 0.222349735484162 no 750 0.264024748816091 1369 1246798
SGTC_36 0335-0881 14.2 µM 0.630826981758533 0.22239949095672 no 751 0.264076829603303 1245 23828853
SGTC_2571 chrysanthemic acid 100 µM 0.630139022066599 0.22261444704838 no 752 0.264301815404849 1240 2743 An insecticide.
SGTC_1958 st076513 41.9 µM 0.629656686800452 0.22276522546982 no 753 0.264459613328878 1250 732122 YGL099W LSG1
SGTC_1523 st012844 44.7 µM 0.628939674596243 0.222989471627655 no 754 0.264694275336969 1324 4274103
SGTC_1255 0566-0045 221 µM 0.625681077713893 0.224010218902237 no 755 0.265762073506662 1348 2788469
SGTC_3259 9138485 49.47 µM 0.624298703131006 0.224444044904457 no 756 0.266215717732983 1416 17646153
SGTC_1982 st072467 71.9 µM 0.623613563151962 0.224659236693132 no 757 0.266440700541606 1293 3163533
SGTC_2312 7706453 155.7 µM 0.622174841757326 0.225111497333783 no 758 0.26691345346817 1328 976098
SGTC_833 3852-0053 558 µM 0.622022244169751 0.225159496472295 no 759 0.266963620720887 1385 3123681
SGTC_523 1934-0222 13.7 µM 0.621730229101865 0.225251365145385 no 760 0.267059635472381 1307 1361595
SGTC_1219 1469-0211 33.1 µM 0.621263865614267 0.225398128286209 no 761 0.267213012253787 1277 6822282
SGTC_2856 9022925 19.48 µM 0.620662306880527 0.225587516881721 no 762 0.267410917439583 1316 4944862
SGTC_1090 efavirenz 20.7 µM 0.617729232806019 0.226512224792491 no 763 0.268376919405459 1329 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2607 solasodine 47.35 µM 0.617303291353937 0.226646688742767 no 764 0.268517348148837 1324 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.616667407478852 0.226847512480481 no 765 0.268727061573858 1295 17037758
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.616407685536932 0.226929566275676 no 766 0.268812741091513 1283 5355888
SGTC_1945 st075991 56.6 µM 0.616153321513244 0.227009943569575 no 767 0.268896666385074 1234 1084980
SGTC_1330 1469-0054 61.8 µM 0.613054606103568 0.227990404515239 no 768 0.26992011696881 1338 7102664
SGTC_2886 9058944 51.95 µM 0.612545090632811 0.228151847438501 no 769 0.270088587332259 1217 4949929
SGTC_1784 st039334 36.3 µM 0.611756034974173 0.228401991091239 no 770 0.270349590920801 1393 3496984
SGTC_2638 epoxomicin 18 µM 0.611583144290792 0.228456820863753 no 771 0.270406796482684 1334 9915668 A protesome inhibitor.
SGTC_964 1287-0107 19.4 µM 0.610974423442914 0.228649926694211 no 772 0.270608256385089 1381 51516812 YPR165W RHO1
SGTC_1726 st035556 14.5795 µM 0.610387254351187 0.228836282433314 no 773 0.270802654608567 1422 5919439
SGTC_1602 st001878 87.6 µM 0.609941751429365 0.228977733022361 no 774 0.270950196907445 1354 595405 YLR310C CDC25
SGTC_299 1273-0059 1.44 µM 0.609918152368247 0.228985227272936 no 775 0.270958013596902 1299 2848077
SGTC_2691 st077356 60.2 µM 0.609915095462546 0.228986198051171 no 776 0.270959026140439 1383 2839272
SGTC_1734 st037168 69.4 µM 0.609540135471254 0.229105291201513 no 777 0.271083239025798 1317 708907
SGTC_245 methotrexate 289.6 µM 0.607419099755583 0.229779618999759 no 778 0.271786408137254 1352 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3002 9075603 71.4286 µM 0.606832162476924 0.2299664164813 no 779 0.271981150731141 1304 20105405
SGTC_127 0180-0333 59.125 µM 0.606310636713776 0.230132467512599 no 780 0.272154248349522 1298 771601
SGTC_1647 st011722 22.4 µM 0.606270993593398 0.230145092414095 no 781 0.272167408384908 1336 2854783
SGTC_1159 4092-0538 61.2 µM 0.605149118956893 0.23050252954278 no 782 0.272539959945198 1372 717301
SGTC_1035 k081-0041 55.2 µM 0.604163590619621 0.230816781623439 no 783 0.272867442461337 1329 731709
SGTC_1168 k815-0004 80.5 µM 0.603055316946697 0.231170458740637 no 784 0.27323594517731 1313 642433
SGTC_1807 st050092 58.9 µM 0.602729700473186 0.231274428330102 no 785 0.273344259999029 1306 5008496
SGTC_514 4466-0038 2.65 nM 0.602417789061664 0.231374046338661 no 786 0.273448035831452 1293 5722064
SGTC_2257 7960413 200 µM 0.601883080972601 0.231544876626175 no 787 0.273625983561558 1315 2974689 YIL048W NEO1
SGTC_287 k060-0039 29.6 µM 0.601210603673843 0.231759821652028 no 788 0.273849861392933 1395 5861974
SGTC_408 cantharidin 100 µM 0.600862313745778 0.231871189818291 no 789 0.273965847951592 1334 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1096 rimcazole 32.2 µM 0.600486193090071 0.231991490524127 no 790 0.274091129885451 1283 18528119 A dopamine reuptake inhibitor.
SGTC_2289 7946404 165.07 µM 0.598138330553274 0.232743230127444 no 791 0.274873818050835 1366 1246120 YPR165W RHO1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.5979062818226 0.232817601023789 no 792 0.274951234054245 1382 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3328 9140624 29.0385 µM 0.597062786608925 0.233088049817496 no 793 0.275232731054441 1376 4904392
SGTC_2010 4012422 159 µM 0.597029013934621 0.233098881937645 no 794 0.275244004855982 1362 952393
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.596654625526411 0.233218980584095 no 795 0.275368996285024 1317 75037 A free radical scavenger.
SGTC_1493 4348-0038 111 µM 0.595317521845086 0.233648185280373 no 796 0.275815622859039 1400 800424
SGTC_2411 st077133 39.94 µM 0.594688537299463 0.233850238052442 no 797 0.276025842699019 1489 1403142 YNL221C POP1
SGTC_2740 felodipine 17.08 µM 0.591978032981963 0.234722057597071 no 798 0.276932649180632 1372 3333 L-type calcium channel blocker
SGTC_2967 9089538 49.85 µM 0.590143501642154 0.235313143263204 no 799 0.277547223145345 1401 728216
SGTC_2079 5212404 121 µM 0.589319825669335 0.235578798566947 no 800 0.277823373904801 1396 758462
SGTC_1419 3993-2473 62.6 µM 0.587497243025366 0.236167212940231 no 801 0.278434900767897 1393 704026
SGTC_1184 1269-1718 139 µM 0.586031422724078 0.236641034594406 no 802 0.278927199403011 1437 5403821
SGTC_802 4112-3352 742 µM 0.583783745817644 0.237368603545911 no 803 0.279682907633387 1458 704594
SGTC_340 k038-0059 454 µM 0.582950734908499 0.237638559305042 no 804 0.279963232597815 1385 23733424
SGTC_2124 5246320 200 µM 0.581994098235797 0.237948786451572 no 805 0.280285328086594 1379 579342
SGTC_1738 st035555 74 µM 0.581239759448921 0.238193567019522 no 806 0.280539437239791 1364 5331140
SGTC_1868 st057644 42.7 µM 0.581238086046827 0.238194110186572 no 807 0.280540001071681 1350 688665
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.580998147976088 0.238271998345472 no 808 0.280620850877454 1349 15053
SGTC_2938 9059746 27.26 µM 0.580065678857233 0.23857482680532 no 809 0.280935163726987 1378 6471769
SGTC_410 α-linolenic acid 100 µM 0.579156769034623 0.238870206780652 no 810 0.281241698972623 1391 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2515 chrysin 20.77 µM 0.577482722053615 0.239414766155265 no 811 0.281806703554602 1425 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1499 4480-0877 67.3 µM 0.577091990284034 0.239541966828218 no 812 0.281938657429645 1332 2861909
SGTC_635 k038-0028 24.7 µM 0.576601690859239 0.239701633410265 no 813 0.28210427835534 1421 4035102
SGTC_3116 9124943 49.47 µM 0.5752661832526 0.240136837425509 no 814 0.282555644199681 1290 41905195 YPL160W CDC60
SGTC_2724 maprotiline 69.64 µM 0.573730856132946 0.240637688665826 no 815 0.283074972305042 1383 4011 A tricyclic antidepressant.
SGTC_1727 st034309 9.9045 µM 0.572341240998831 0.24109149584832 no 816 0.283545407570158 1494 870305
SGTC_1616 st002734 56.1 µM 0.572179397436062 0.241144379401867 no 817 0.283600221849741 1386 4026101
SGTC_2095 5432005 200 µM 0.570327777577521 0.241749858107251 no 818 0.284227702085749 1368 783734
SGTC_713 1488-1073 324 µM 0.569723879214244 0.241947510837946 no 819 0.28443249568624 1362 3312542
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.567687473669937 0.242614661280223 no 820 0.285123599342315 1354 803109
SGTC_3210 9128157 49.47 µM 0.567377101501477 0.242716430265475 no 821 0.285229001924653 1378 17590849
SGTC_26 0302-0163 425.158 µM 0.56699193645695 0.242842755466947 no 822 0.285359830025317 1393 3100915
SGTC_1293 1000-1278 195 µM 0.566737070234287 0.242926365233537 no 823 0.285446415543311 1438 678847
SGTC_263 alizarin 107.927 µM 0.565454971766293 0.243347198304781 no 824 0.28588217156803 1417 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1174 0739-0097 51.1 µM 0.565325949622969 0.243389570045834 no 825 0.285926040761177 1403 728447
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.56522898463145 0.243421416625937 no 826 0.285959012215292 1458 23847180
SGTC_281 1672-3440 14.9 µM 0.565222955258 0.243423396950286 no 827 0.285961062470687 1398 6833000
SGTC_2267 7931562 200 µM 0.564112919402557 0.243788132202832 no 828 0.286338643082865 1298 934880
SGTC_291 SEC14.278 35.5 µM 0.562259631774292 0.244397741700817 no 829 0.286969568978344 1441 1068044
SGTC_3267 9137951 49.47 µM 0.562225838812583 0.24440886497881 no 830 0.286981079431211 1422 16643986
SGTC_1590 st077108 57.8 µM 0.561299713372359 0.244713814222645 no 831 0.287296618474268 1386 5489485
SGTC_822 1487-0950 154 µM 0.561276000859943 0.244721624830808 no 832 0.287304699689784 1410 1958375
SGTC_159 3970-0959 50 µM 0.56019926911351 0.245076428321302 no 833 0.287671762749215 1455 6615653
SGTC_3071 9117417 49.47 µM 0.560173023276944 0.245085080274259 no 834 0.287680712848066 1381 45595590 YGL055W OLE1
SGTC_3215 9129942 49.47 µM 0.5587394497976 0.245557907938049 no 835 0.288169775845544 1363 17682944
SGTC_1723 st034307 2.5525 µM 0.557385128865074 0.246005045901869 no 836 0.28863216187587 1410 867466
SGTC_1266 0828-0227 32.9 µM 0.556527556695574 0.246288404712757 no 837 0.288925130816862 1422 3913820
SGTC_2997 9067075 71.4286 µM 0.556098140848217 0.246430357921066 no 838 0.289071882988852 1441 27209819
SGTC_1673 st016611 27.3 µM 0.555205288610472 0.24672565090788 no 839 0.289377125973292 1487 5226799
SGTC_785 1270-0111 65.3 µM 0.553950394249806 0.247141002150436 no 840 0.289806397566714 1385 6741994
SGTC_383 2324-0395 7.37 µM 0.553617341800235 0.247251300289724 no 841 0.289920377585718 1463 3146421
SGTC_2065 5221596 34.26 µM 0.553591226676743 0.247259950038777 no 842 0.289929315812346 1433 788581
SGTC_612 0302-0167 22.4 µM 0.55139186732828 0.247988993465695 no 843 0.290682537253938 1491 235821
SGTC_819 1013-0258 27.7 µM 0.550345274872606 0.248336320187091 no 844 0.291041288137224 1398 5753198
SGTC_1935 st074532 41.6 µM 0.550007751769517 0.248448387347046 no 845 0.291157028372292 1494 2829742
SGTC_2155 5570423 76 µM 0.549903690633798 0.248482944004664 no 846 0.291192716368398 1412 797402
SGTC_2883 9059145 45.46 µM 0.549743042231367 0.248536297209898 no 847 0.291247815102427 1388 16476510
SGTC_3090 9117696 49.47 µM 0.547789473283274 0.249185588319545 no 848 0.291918233747978 1479 7923821
SGTC_886 0866-0150 153 µM 0.545538402095822 0.249934874919099 no 849 0.292691638136583 1515 271463
SGTC_2036 5160441 105 µM 0.544593117352184 0.25024987644287 no 850 0.293016694728953 1468 134534 YIL048W NEO1
SGTC_1244 0416-0015 52.5 µM 0.54328642585723 0.250685657571155 no 851 0.293466304407026 1419 96201
SGTC_2284 7945075 39.21 µM 0.542693798418145 0.250883430993839 no 852 0.293670322414622 1497 1245402
SGTC_356 1634-0012 32.5 µM 0.539389801733965 0.251987562810023 no 853 0.294808958218375 1447 735457
SGTC_2597 laccaic acid a 100 µM 0.53868071553263 0.252224859472666 no 854 0.295053591198639 1441 5491415 A textile dye.
SGTC_2434 5670830 169.91 µM 0.538488552178826 0.252289187489069 no 855 0.295119903178537 1426 1549830
SGTC_353 1988-1175 58.3 µM 0.536662163276844 0.252901015390934 no 856 0.29575049813817 1364 2788357
SGTC_323 4013-0906 34.3 µM 0.534885139697178 0.253497054955738 no 857 0.296364642346532 1497 2910086
SGTC_2917 7979103 53.79 µM 0.534787926781488 0.253529682862754 no 858 0.296398256257156 1508 2980565
SGTC_622 1348-1566 26.3 µM 0.533758743497963 0.253875246491256 no 859 0.296754230463811 1504 7340407
SGTC_3265 9137266 49.47 µM 0.531780198275371 0.254540266366655 no 860 0.297439119485499 1463 17224265
SGTC_98 0074-0023 107.663 µM 0.529635352548479 0.255262211987576 no 861 0.298182389109314 1377 3563821
SGTC_2830 7992007 71.43 µM 0.529326991629491 0.255366092860221 no 862 0.29828931727069 1453 1952075
SGTC_767 0929-0023 86 µM 0.526923924491215 0.256176396436132 no 863 0.29912320953812 1461 1204563
SGTC_271 rotenone 740 µM 0.526607281460498 0.256283266941673 no 864 0.299233167212879 1472 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1411 3909-8223 150 µM 0.52587210547447 0.256531486514018 no 865 0.299488535623577 1503 X1411
SGTC_887 0885-0007 9.62 µM 0.525051121888729 0.256808825487378 no 866 0.299773826594193 1509 5719458
SGTC_1213 1315-0166 115 µM 0.524900935825016 0.256859577180772 no 867 0.299826029413379 1394 768401
SGTC_1091 telmisartan 47.6 µM 0.524791364126814 0.256896607539274 no 868 0.299864117777771 1515 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_376 3970-0862 59.1 µM 0.524650148934849 0.256944336087474 no 869 0.299913209009604 1520 3135186
SGTC_1617 st002906 78 µM 0.523973930259707 0.257172951454326 no 870 0.300148336152919 1435 5150859
SGTC_1242 0402-0103 60.1 µM 0.523171226779862 0.257444465904484 no 871 0.300427551323449 1408 432868
SGTC_2912 7964298 10.93 µM 0.522047611865641 0.257824778632793 no 872 0.300818590399883 1453 2975850
SGTC_1722 st034304 3.6505 µM 0.521021401536621 0.258172377162722 no 873 0.301175931331924 1434 4036148 YLR033W RSC58
SGTC_2371 9071574 200 µM 0.520134668469624 0.258472927427524 no 874 0.301484858236932 1431 45596039
SGTC_1190 1486-1332 13 µM 0.519540114299717 0.258674547711384 no 875 0.301692073429254 1419 4150046
SGTC_3277 9138724 49.47 µM 0.519467535824309 0.258699165497444 no 876 0.301717373008131 1429 15943418
SGTC_2409 alverine citrate 63.97 µM 0.518344699682145 0.259080173088373 no 877 0.30210889538955 1576 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2496 diffractaic acid 79.83 µM 0.518339992379772 0.259081771009387 no 878 0.30211053726158 1575 94870 An apoptosis inducer which activates caspases.
SGTC_3131 9127911 49.47 µM 0.517528670807865 0.259357254918297 no 879 0.302393580012388 1493 45595681
SGTC_2925 9010536 32.5 µM 0.516962276951063 0.259549663387412 no 880 0.302591246205215 1541 2994177
SGTC_854 0422-0053 192 µM 0.516341486576913 0.259760635416055 no 881 0.302807962767407 1439 3596728
SGTC_2752 diclazuril 33.15 µM 0.515899503707297 0.259910894658859 no 882 0.30296230036618 1487 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_888 0916-0002 6.97 µM 0.512921122418881 0.260924611404786 no 883 0.304003248714488 1504 2802138 YIL048W NEO1
SGTC_48 0382-0018 55 µM 0.51213328498543 0.26119309806584 no 884 0.30427886541833 1585 762596
SGTC_1407 3909-7909 12.3 µM 0.511245204264293 0.261495916701252 no 885 0.304589684540439 1453 4411780
SGTC_3040 9091894 49.47 µM 0.510767614807081 0.261658840122624 no 886 0.304756894317101 1437 25236966
SGTC_1322 1348-1070 12 µM 0.510492446740109 0.261752733770862 no 887 0.304853252470491 1440 6758089
SGTC_2078 5212016 200 µM 0.509792443486636 0.26199166881044 no 888 0.305098440106183 1468 1899708
SGTC_2211 7117706 200 µM 0.50948695658985 0.262095976966673 no 889 0.305205469343024 1509 822771
SGTC_2563 tomatine 8.54 µM 0.509398891374423 0.26212605068687 no 890 0.305236326633561 1588 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_204 PMA1.184 62.41 µM 0.509010510747822 0.262258701334672 no 891 0.305372428361205 1468 2252213 YGL008C PMA1
SGTC_175 3793-3120 23.7 µM 0.506911899458268 0.262976072386374 no 892 0.306108317993944 1459 5322297
SGTC_3069 9117009 49.47 µM 0.50649483872512 0.263118756188166 no 893 0.306254656015742 1415 41904981
SGTC_2934 9036370 36.88 µM 0.504672242561754 0.263742762160247 no 894 0.306894529984091 1588 6462800
SGTC_477 mead ethanolamide 10 µM 0.504049378291756 0.263956186380459 no 895 0.30711333919588 1414 16061185
SGTC_2067 5224629 34.075 µM 0.503975615758151 0.263981466914494 no 896 0.307139256169236 1444 2835000
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.500440779631996 0.26519440129354 no 897 0.308382372604986 1438 6708760
SGTC_158 k038-0087 26.446 µM 0.499526920502116 0.265508440278136 no 898 0.30870411330776 1521 X158
SGTC_33 0986-0033 35.816 µM 0.498773171961501 0.265767600683526 no 899 0.308969594732938 1468 2848082
SGTC_1504 k297-0033 30 µM 0.498146978893841 0.265983001326969 no 900 0.309190225147533 1405 4388117
SGTC_1546 5-methoxyflavanone 78.7 µM 0.497298732142667 0.266274925947529 no 901 0.309489202850147 1547 147795
SGTC_957 1187-1561 14.1 µM 0.496810834110934 0.266442909775361 no 902 0.309661227221943 1464 1538454
SGTC_166 k072-0058 166.424 µM 0.495481843423706 0.266900754469545 no 903 0.310130017672423 1500 5846229
SGTC_595 3909-8003 73.7 µM 0.494525849752208 0.267230345215691 no 904 0.31046742751018 1516 699517
SGTC_1125 tnp00248 1.32998 µM 0.490376428587519 0.268663286474991 no 905 0.311933776611903 1635 24207736
SGTC_1978 st071761 42 µM 0.490258091447448 0.268704209010292 no 906 0.311975639245461 1439 5147680
SGTC_1556 plumbagin 1.48 µM 0.489680939553137 0.26890384057863 no 907 0.312179845773369 1463 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2391 6285546 200 µM 0.488784218722118 0.269214155787223 no 908 0.31249723592251 1470 846083
SGTC_2165 5727197 32.143 µM 0.484972780139278 0.270535126393479 no 909 0.313847827047605 1593 1361712
SGTC_846 0335-0850 148 µM 0.48310570767725 0.271183397031049 no 910 0.314510340799722 1504 6819598
SGTC_2568 diosmetin 100 µM 0.482073294451873 0.271542195910142 no 911 0.314876940089302 1514 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_549 1661-1316 519 µM 0.481519949920387 0.271734599315 no 912 0.315073502166228 1602 2857282
SGTC_2654 protoveratrine a 100 µM 0.481326525334444 0.271801870971555 no 913 0.315142223865064 1500 5702278 A heart drug and vasodilator.
SGTC_2341 7987486 176.74 µM 0.480659371082102 0.272033965912667 no 914 0.315379305759238 1630 1258686
SGTC_2033 5192550 145 µM 0.47912896634213 0.272566747373866 no 915 0.315923442023046 1483 182073
SGTC_2857 9024691 58.44 µM 0.478097824601115 0.272926011723702 no 916 0.316290290170476 1522 16478292
SGTC_844 0330-0132 15.3 µM 0.477034340221284 0.273296790522238 no 917 0.316668834314866 1564 2828079
SGTC_2346 9031566 143.75 µM 0.474551794634971 0.274163288092975 no 918 0.317553236133603 1592 4771086
SGTC_2525 harmine 47.85 µM 0.472085527604538 0.275025445429909 no 919 0.318432871051498 1595 5280953 A monoamine oxidase inhibitor
SGTC_81 0411-0046 9.971 µM 0.471231605967433 0.275324270219079 no 920 0.318737675363625 1457 12925265
SGTC_84 0443-0269 128.823 µM 0.469211202376261 0.276031934086877 no 921 0.319459339480018 1488 6150058
SGTC_1151 3909-8316 15.3 µM 0.46859003370863 0.276249683168057 no 922 0.319681351208393 1513 800431
SGTC_1521 st012942 49.4 µM 0.466995880453405 0.276808894931662 no 923 0.320251412713395 1708 24207259
SGTC_579 4491-1009 110 µM 0.466495653443469 0.276984483393621 no 924 0.320430379039964 1668 1271041
SGTC_481 bay k-8644 50 µM 0.465910150382287 0.277190074483563 no 925 0.320639907650132 1487 2303 A calcium channel antagonist.
SGTC_820 1582-0060 59.9 µM 0.464269834346766 0.277766445415215 no 926 0.321227216737347 1504 3848840
SGTC_3344 9148862 3.898 µM 0.463001670633129 0.278212450979622 no 927 0.321681584807623 1614 4905352
SGTC_798 1287-0182 476 µM 0.460209985068346 0.279195498777921 no 928 0.322682752288199 1665 1649755
SGTC_3019 9081971 49.47 µM 0.460100795473346 0.279233982445987 no 929 0.322721936572264 1650 16451803
SGTC_580 1123-0028 41 µM 0.4599486390381 0.27928761399533 no 930 0.322776543418654 1554 1677248 YPR107C YTH1
SGTC_1154 4088-0362 150 µM 0.459736329428387 0.27936245648163 no 931 0.322852744796358 1500 6618304
SGTC_613 3914-0030 117 µM 0.456867804851608 0.280374610650136 no 932 0.323883033045291 1484 1145395
SGTC_1630 st005209 31.3 µM 0.45607090519468 0.28065611021839 no 933 0.324169495671956 1588 3367314
SGTC_2872 9044037 25.97 µM 0.455540243862293 0.280843638654268 no 934 0.324360311005881 1638 6465195
SGTC_2869 9037858 32.47 µM 0.455171864613174 0.280973854441509 no 935 0.324492800038591 1472 27187042
SGTC_1119 parthenolide 318.541 nM 0.45485065992501 0.281087418631992 no 936 0.324608340688665 1646 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_322 k048-0136 19.3 µM 0.454431507673577 0.281235646215382 no 937 0.324759139477802 1534 6823282
SGTC_1049 3226-0134 66 µM 0.452269437277775 0.282000832333145 no 938 0.325537445307922 1554 5702385
SGTC_2032 5185112 25.99 µM 0.452024181176611 0.28208769508658 no 939 0.325625781161829 1558 5718189
SGTC_560 2332-1943 155 µM 0.450502903389109 0.282626776114996 no 940 0.326173930578571 1567 21177716
SGTC_2417 cerulenin 830 nM 0.450156281523593 0.282749674502775 no 941 0.326298878566346 1581 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2639 lactacystin 53 µM 0.447930884129366 0.283539323284618 no 942 0.327101539210992 1640 3870 A proteasome inhibitor.
SGTC_799 1310-0557 151 µM 0.444405126459321 0.28479254444648 no 943 0.32837485386281 1584 5354492
SGTC_2307 7538926 6.34 µM 0.44430584589791 0.284827871686405 no 944 0.328410737642104 1549 96582
SGTC_2511 berberine 10.47 µM 0.443902862361056 0.284971287747416 no 945 0.328556407502677 1557 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2175 5807670 165.306 µM 0.443356129684496 0.285165917104582 no 946 0.32875408123729 1562 241186
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.443211878644877 0.285217279062936 no 947 0.328806243861355 1526 23665772 A membrane-active detergent.
SGTC_32 0928-0142 34.1 µM 0.439415409343448 0.286570630299389 no 948 0.330180281546349 1591 2244242
SGTC_54 0159-0055 9 µM 0.437723893932985 0.287174594783687 no 949 0.330793223230518 1683 3319099
SGTC_2824 7998404 51.95 µM 0.437440835071562 0.287275721263664 no 950 0.330895837517066 1596 837851
SGTC_679 0422-0091 41.4 µM 0.436821907898845 0.287496899779212 no 951 0.3311202547909 1517 627384 YHR062C RPP1
SGTC_1530 rhein 70.4 µM 0.435460472855638 0.287983702513745 no 952 0.331614112005696 1575 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1039 k821-0043 94 µM 0.434967664169256 0.288160009960846 no 953 0.331792949377333 1674 15992768
SGTC_250 brefeldin a 552.239 µM 0.43443451487933 0.288350807008068 no 954 0.331986469290421 1527 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2215 7188065 200 µM 0.434104696934296 0.288468868095377 no 955 0.332106207436001 1633 940217
SGTC_2620 irigenin 100 µM 0.434060709416746 0.288484615516213 no 956 0.332122178098921 1681 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1740 st038286 13.222 µM 0.434055797786849 0.288486373892528 no 957 0.332123961396147 1607 716786
SGTC_2107 5363541 170.161 µM 0.434045805412956 0.288489951204035 no 958 0.332127589403681 1575 244052
SGTC_1526 st051518 75 µM 0.433598751004252 0.2886500199315 no 959 0.332289920959147 1579 673993
SGTC_2223 6903751 107.57 µM 0.432896173805257 0.288901663602228 no 960 0.332545099906974 1613 5598863
SGTC_473 2-arachidonoylglycerol 10 µM 0.431219414639572 0.289502649087613 no 961 0.333154419274975 1554 5282280 An endocannabinoid.
SGTC_1939 st074455 53.6 µM 0.430593757231221 0.289727048078213 no 962 0.333381890594154 1714 1644229
SGTC_1998 st075797 76.8 µM 0.429482899383218 0.290125670594588 no 963 0.333785918025425 1667 24208315
SGTC_586 0957-0265 8.15 µM 0.428542533742842 0.290463314077907 no 964 0.334128086851926 1571 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1305 1181-0477 144 µM 0.427554774467768 0.290818172448073 no 965 0.334487649212839 1676 6252086
SGTC_2601 securinine 100 µM 0.42715169962782 0.290963037677082 no 966 0.334634419445147 1544 442872 A GABA receptor antagonist.
SGTC_731 3966-0296 387 µM 0.426189871533901 0.291308855167779 no 967 0.334984748613592 1594 660956
SGTC_3308 9128332 17.569 µM 0.425264965677675 0.291641578375212 no 968 0.335321764973675 1707 17332805 YDL196W YDL196W
SGTC_2433 5607874 27.82 µM 0.424508322038411 0.291913903047873 no 969 0.335597568708164 1535 2252428
SGTC_435 c-PAF 6.7 µM 0.423036367731186 0.292444015196634 no 970 0.336134363643184 1590 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1361 1608-0041 5.61 µM 0.422687247914753 0.292569813434065 no 971 0.336261730376008 1569 X1361
SGTC_487 nimodipine 119 µM 0.422654555303666 0.292581594840124 no 972 0.336273658335876 1651 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1318 1280-3875 124 µM 0.422368780682035 0.29268458856046 no 973 0.336377930753332 1598 373245
SGTC_3217 9129673 49.47 µM 0.421152267900138 0.293123210400642 no 974 0.33682194831522 1590 17248312
SGTC_1404 3909-7820 48.3 µM 0.419121340473946 0.293856153382911 no 975 0.337563727560687 1686 23741373
SGTC_828 2074-0507 139 µM 0.418655845819236 0.29402426545679 no 976 0.337733834661994 1695 X828
SGTC_2696 st077691 74.316 µM 0.417516454021383 0.294435941058563 no 977 0.33815034583873 1614 757133
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.416237564540483 0.294898335486739 no 978 0.338618087237913 1588 442882
SGTC_2074 5212007 75.395 µM 0.414991903187843 0.295349037440499 no 979 0.339073915210211 1714 758611
SGTC_115 0527-0192 112.043 µM 0.412988297078409 0.296074641108604 no 980 0.339807594000482 1612 4233931
SGTC_3146 9095609 49.47 µM 0.412277851731394 0.296332124415014 no 981 0.340067890260782 1672 17173999
SGTC_1127 asiatic acid 681.4 nM 0.409160641215565 0.297463091718104 no 982 0.341210888125845 1573 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2125 5246583 200 µM 0.407535302303126 0.298053568015326 no 983 0.341807435689691 1776 835267
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.407092808264062 0.298214416011587 no 984 0.341969912629607 1721 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1684 st024538 14.6195 µM 0.406858187305065 0.298299717513646 no 985 0.342056073678668 1597 6732859
SGTC_2110 5483698 200 µM 0.406589482055179 0.298397424737879 no 986 0.342154761779375 1634 2848765 YHR062C RPP1
SGTC_551 k048-0028 34.9 µM 0.40585837896316 0.298663343833969 no 987 0.342423330543498 1695 6836383
SGTC_2177 5811945 192 µM 0.404751265163691 0.299066231701601 no 988 0.342830177526669 1696 5343475
SGTC_897 1000-0139 31.4 µM 0.404727387343614 0.299074923755492 no 989 0.342838954261957 1740 6151020
SGTC_489 paxilline 115 µM 0.404251215545789 0.299248284750546 no 990 0.343013997736726 1580 105008 A toxic potassium channel blocker.
SGTC_9 0092-0002 10.449 µM 0.403484287276232 0.299527597953016 no 991 0.343295995782822 1619 759368
SGTC_3123 9126162 49.47 µM 0.402600166691242 0.29984973882655 no 992 0.343621193508112 1638 25239884
SGTC_2846 9008642 19.48 µM 0.402425030818787 0.299913570475281 no 993 0.343685625827195 1604 2992898
SGTC_1632 st005650 90 µM 0.402331822144302 0.299947544683005 no 994 0.343719919060627 1619 2759605
SGTC_1795 st049545 62.3 µM 0.400870894099446 0.300480274828775 no 995 0.344257589994908 1736 5291882
SGTC_2290 7904846 200 µM 0.399755449732622 0.300887311188201 no 996 0.344668323355067 1601 2962154
SGTC_1650 st011916 45.8 µM 0.399080545752467 0.301133710814606 no 997 0.344916928161158 1721 242528
SGTC_1719 st032227 49.2 µM 0.397128512764915 0.301846886676276 no 998 0.345636347484509 1570 3125804
SGTC_2457 5731572 11.68 µM 0.396185075610622 0.302191843597157 no 999 0.345984250198372 1754 2865357
SGTC_3340 9146634 11.102 µM 0.396111854719921 0.302218623369475 no 1000 0.346011256640523 1617 4907387
SGTC_254 nsc-64875 3.808 µM 0.395702840474264 0.302368235624474 no 1001 0.346162129898447 1749 56993
SGTC_880 0833-0487 87.2 µM 0.394381422639434 0.302851820484191 no 1002 0.346649728641103 1605 76075
SGTC_1509 1326-1131 80 µM 0.393693751235599 0.30310361699525 no 1003 0.346903577679505 1742 768313
SGTC_942 3253-1115 227 µM 0.391009215755455 0.304087476656473 no 1004 0.34789521194555 1737 46497897
SGTC_3238 9133470 49.47 µM 0.390883429774668 0.30413361104842 no 1005 0.34794170132326 1728 3534688
SGTC_2591 skatole 100 µM 0.390368852974764 0.304322374307725 no 1006 0.348131908119467 1639 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3063 1327-0034 4 µM 0.390132730580712 0.304409009025663 no 1007 0.348219200564083 1650 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_430 0958-0115 16.4 µM 0.389019530962709 0.304817596415181 no 1008 0.348630849269413 1637 6833180
SGTC_1490 4089-0339 670 nM 0.388644454262913 0.304955318973672 no 1009 0.348769588598255 1748 742542
SGTC_1961 st076550 68.7 µM 0.387065402675483 0.305535425994565 no 1010 0.349353894903397 1662 1579337
SGTC_1920 st075728 45.7 µM 0.386728459396202 0.305659274454095 no 1011 0.349478622414991 1786 3400306
SGTC_1187 1391-0724 117 µM 0.386177159046133 0.305861960958482 no 1012 0.349682734306186 1679 6997986
SGTC_334 1502-1024 68.5 µM 0.385503257747921 0.306109802692121 no 1013 0.349932296654209 1667 3296216
SGTC_1352 1496-0991 99 µM 0.384973386279357 0.306304736701428 no 1014 0.350128566728232 1633 3000039
SGTC_3317 9138495 8.753 µM 0.384740299875382 0.306390504051421 no 1015 0.350214917115321 1639 17020139
SGTC_1921 5740136 50 µM 0.384397143076224 0.306516792622715 no 1016 0.350342058838518 1788 1774243
SGTC_1030 k029-0042 36.7 µM 0.383646515933474 0.306793118535289 no 1017 0.350620229304142 1664 6080581
SGTC_11 0438-0307 1.3 µM 0.383640721173029 0.306795252168867 no 1018 0.350622377061892 1747 4011476
SGTC_2793 7325131 81.82 µM 0.382537421320378 0.307201606901669 no 1019 0.351031388711784 1698 4176441
SGTC_1088 bifonazole 369 nM 0.380254745398965 0.308043087457463 no 1020 0.351878162409999 1641 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1440 4100-1550 40 µM 0.379853068483473 0.308191265380498 no 1021 0.352027243300459 1653 742806
SGTC_1645 Cervolide 78 µM 0.376561735517631 0.309406608386174 no 1022 0.353249664277769 1652 23173 A fragrance.
SGTC_237 nikkomycin 200 µM 0.375745931317899 0.30970817201565 no 1023 0.353552893783865 1745 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1574 spiramycin 23.7 µM 0.37512972125409 0.309936040235799 no 1024 0.353781996991544 1604 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1433 4060-0023 7.6 µM 0.373987007978916 0.310358797239194 no 1025 0.354206991061265 1710 3840627
SGTC_1406 3909-7906 11.9 µM 0.373377266755472 0.310584479067369 no 1026 0.354433838321106 1699 X1406
SGTC_984 1492-0255 2.91 µM 0.372780773112571 0.310805326608803 no 1027 0.354655806950005 1698 1585198
SGTC_1217 1183-1422 255 µM 0.371928009301602 0.311121174756591 no 1028 0.354973225154448 1757 2849664
SGTC_693 4161-2696 114 µM 0.367893834244888 0.31261724261911 no 1029 0.356476198941742 1760 805759
SGTC_512 prima-1 270 µM 0.366560812857016 0.313112272710827 no 1030 0.356973321610528 1745 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2518 prenyletin 46.28 µM 0.363809282268637 0.314135144744137 no 1031 0.358000215359955 1769 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3030 9087619 49.47 µM 0.361714043374937 0.31491500177247 no 1032 0.358782865794223 1652 25236973
SGTC_3245 9134821 49.47 µM 0.361160294542803 0.315121247631783 no 1033 0.358989811041937 1594 17014901
SGTC_2413 inermin 26.06 µM 0.361034184711103 0.315168225779793 no 1034 0.35903694619468 1806 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.359840416975653 0.315613073417932 no 1035 0.35948323828104 1716 66535 A nucleotide analog.
SGTC_1587 estradiol valerate 56.1 µM 0.359364947448357 0.315790327662846 no 1036 0.359661046795253 1820 13791 A steroid.
SGTC_1892 st058411 7.36 µM 0.359166262529404 0.315864409623641 no 1037 0.359735356817088 1772 3934738
SGTC_1343 1487-0095 224 µM 0.358837984713625 0.315986827994838 no 1038 0.359858147415143 1795 4560101 YGL055W OLE1
SGTC_142 0335-0849 62.6745 µM 0.358827167853058 0.315990862063412 no 1039 0.359862193651434 1708 3889043 YPR107C YTH1
SGTC_775 4577-0580 57.3 µM 0.357082331426775 0.316641872526539 no 1040 0.360515085600138 1728 2006902
SGTC_2837 9008476 45.46 µM 0.355913706770504 0.317078212383535 no 1041 0.360952595278356 1740 2992805
SGTC_1971 st069429 63.5 µM 0.35569568991253 0.317159643473429 no 1042 0.36103423658668 1810 1246522 YGL099W LSG1
SGTC_1838 st055369 84.5 µM 0.354005243017095 0.317791339522983 no 1043 0.361667476996303 1660 676036
SGTC_2201 6605497 169.863 µM 0.353864457530673 0.317843973028231 no 1044 0.361720232277561 1772 670741
SGTC_1016 4226-1401 38 µM 0.353767788586645 0.317880115428703 no 1045 0.361756457684976 1666 2901613
SGTC_2732 terfenadine 20 µM 0.353022029716399 0.318158996632936 no 1046 0.362035962573679 1725 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1032 k061-1018 98.7 µM 0.351796893020272 0.318617367984661 no 1047 0.362495294409732 1848 4005393
SGTC_3018 9082602 49.47 µM 0.350078666686032 0.319260691133604 no 1048 0.363139830316227 1709 17332089
SGTC_1779 st039427 55 µM 0.348656105372314 0.319793726197402 no 1049 0.36367375077562 1893 1124498
SGTC_826 1683-5028 118 µM 0.347875913319941 0.320086223084807 no 1050 0.363966687593827 1707 722377
SGTC_2989 9073649 71.4286 µM 0.347265404545519 0.320315183107168 no 1051 0.364195969307369 1845 21367202
SGTC_2794 7785382 27.27 µM 0.34582955645974 0.320853940941449 no 1052 0.364735405640714 1876 2205081
SGTC_361 000s-0510 1.45 µM 0.344325660918639 0.321418636256844 no 1053 0.365300694103133 1709 660
SGTC_1139 k015-0024 46.9 µM 0.344132530664584 0.321491184376175 no 1054 0.365373309681943 1816 2766652
SGTC_3060 1327-0027 12.5 µM 0.343931979082363 0.321566527476072 no 1055 0.365448720734561 1813 16000455 YPR107C YTH1
SGTC_1940 st075990 51.1 µM 0.343792823964697 0.32161880950219 no 1056 0.365501048653724 1774 1084979
SGTC_792 4534-1957 155 µM 0.34286394148894 0.321967890779846 no 1057 0.365850409897916 1738 1717904
SGTC_1210 3013-0140 750 nM 0.341313635912203 0.322550857629981 no 1058 0.366433741812123 1852 905973
SGTC_1995 st072814 61.1 µM 0.338983238179865 0.323427986271633 no 1059 0.367311178690824 1683 5769371
SGTC_2924 9010168 62.78 µM 0.338875927052212 0.323468400348866 no 1060 0.367351600003431 1704 2993929
SGTC_2572 astragaloside iv 100 µM 0.338237459797845 0.323708894364153 no 1061 0.367592124399494 1733 45006101 An anti-inflammatory agent.
SGTC_1142 3253-1408 9.78 µM 0.338128416525876 0.323749975494336 no 1062 0.367633208549829 1827 256655
SGTC_765 1319-0117 244 µM 0.3379291245609 0.323825062604889 no 1063 0.367708299545269 1656 3487746 YGL099W LSG1
SGTC_1323 1348-1351 11.2 µM 0.335384015963465 0.32478461123532 no 1064 0.368667711935271 1699 6989654
SGTC_690 glyoxal 20.3 µM 0.33446084219462 0.325132951212597 no 1065 0.369015917288274 1720 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1148 3909-7663 27.7 µM 0.334391784821081 0.3251590146927 no 1066 0.369041968874207 1820 4084526
SGTC_2335 9018011 154.17 µM 0.334268380659676 0.325205591746564 no 1067 0.369088524041273 1821 6458208
SGTC_905 2-aminofluorene 215 µM 0.33424868127932 0.325213027235661 no 1068 0.369095955961482 1695 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3062 9077494 49.47 µM 0.333856234811277 0.325361169817873 no 1069 0.369244023139973 1795 16459633
SGTC_3070 9117005 49.47 µM 0.333249106558007 0.325590405883862 no 1070 0.369473126400263 1792 8779016
SGTC_2 0422-0095 29 µM 0.33313653590278 0.325632916931174 no 1071 0.369515610666841 1711 6790840
SGTC_603 3794-0023 45.9 µM 0.333122066428496 0.325638381330599 no 1072 0.369521071575024 1825 3802260
SGTC_2423 st077119 87.2 µM 0.332596877648047 0.32583674431591 no 1073 0.36971930029636 1707 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_181 1447-1644 8.07 µM 0.330720055553407 0.326546019768792 no 1074 0.370427975925619 1851 534600
SGTC_975 1335-0046 28.5 µM 0.330469934596572 0.326640591167656 no 1075 0.370522453223094 1637 16486740
SGTC_3342 9147791 14.508 µM 0.329996392278138 0.326819669286676 no 1076 0.370701344059918 1733 1838168
SGTC_1403 3909-7815 62.9 µM 0.329298462472413 0.327083676095125 no 1077 0.370965053072019 1754 6615483
SGTC_788 1182-0090 188 µM 0.328640709304384 0.327332564462952 no 1078 0.371213637041266 1875 5715185
SGTC_112 phenothiazine 287.218 µM 0.328416692876079 0.327417347963084 no 1079 0.371298311609621 1885 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_750 4073-0104 132 µM 0.328357976429854 0.327439571849831 no 1080 0.371320506502406 1729 22330957
SGTC_644 1498-1197 63.3 µM 0.328116659496292 0.327530915545726 no 1081 0.371411729108731 1796 6741615
SGTC_1872 amphotericin b 148 nM 0.327175866011046 0.327887124842681 no 1082 0.371767436710333 1827 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_701 4424-0219 185 µM 0.326805158734694 0.328027527462357 no 1083 0.371907628695067 1864 2911779
SGTC_3356 9151811 4.48 µM 0.326509646970055 0.328139467753101 no 1084 0.372019395833169 1721 1859254 YPR165W RHO1
SGTC_808 0711-0032 135 µM 0.326095937926244 0.328296207277585 no 1085 0.372175885133362 1871 4252555
SGTC_215 1287-0124 461.5 µM 0.32566901791929 0.32845798365639 no 1086 0.372337393738468 1856 5560863
SGTC_1363 1636-0063 10.4 µM 0.325372631689179 0.328570314695217 no 1087 0.372449533167045 1745 6072185
SGTC_2789 5281112 71.43 µM 0.324033618552757 0.329077996644838 no 1088 0.372956291128741 1669 765948
SGTC_2136 5328288 199.296 µM 0.323628795321795 0.329231546035291 no 1089 0.373109542364805 1705 262395
SGTC_810 3825-7150 143 µM 0.323010635009426 0.329466069726813 no 1090 0.373343593931689 1917 22330411 YGL099W LSG1
SGTC_2037 5169046 200 µM 0.322617715496045 0.329615174250552 no 1091 0.373492387776421 1786 5718022
SGTC_1813 st051246 8.6015 µM 0.321546498725673 0.330021815566709 no 1092 0.373898140302478 1864 5291959
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.320767875595478 0.330317512433628 no 1093 0.374193152769595 1733 6708784 An antioxidant flavonoid
SGTC_200 k038-0079 37.545 µM 0.320763555874166 0.330319153225344 no 1094 0.374194789674218 1774 3436683
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.320105459163559 0.330569161062623 no 1095 0.374444193708965 1723 6312947
SGTC_67 0335-0847 266 µM 0.319915093759624 0.330641494088064 no 1096 0.374516347770802 1946 4552207 YOR254C SEC63
SGTC_176 1486-1328 72.834 µM 0.318835777970259 0.331051720578334 no 1097 0.374925523074527 1692 22310231
SGTC_2439 5492030 7.2 µM 0.318019089606746 0.331362262484315 no 1098 0.375235228315202 1873 5722370
SGTC_358 0075-0058 9.45 µM 0.317226887868746 0.331663604298811 no 1099 0.375535724585087 1985 1069125
SGTC_3075 9116269 49.47 µM 0.316512203988282 0.331935552974744 no 1100 0.375806881754252 1767 17015205 YNL244C SUI1
SGTC_505 gw-5074 63.9 µM 0.316423027498576 0.331969492276649 no 1101 0.375840720383502 1832 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1709 st033179 39.1045 µM 0.316362097629379 0.33199268210992 no 1102 0.375863841188404 1741 573381
SGTC_3172 9105863 49.47 µM 0.315621774156031 0.332274499704883 no 1103 0.376144804251124 1788 2348785
SGTC_1396 3511-0007 98.6 µM 0.31541403785801 0.33235359535649 no 1104 0.376223654870465 1762 X1396
SGTC_139 0099-0334 718.624 µM 0.314961295846692 0.332526002865432 no 1105 0.376395520384916 1852 97690
SGTC_2462 5162487 171.77 µM 0.314398093311039 0.332740524013769 no 1106 0.376609352052808 1883 2259986
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.312556362970323 0.333442412383315 no 1107 0.377308867700958 1718 229346 A bile salt which induces apoptosis.
SGTC_2073 5212005 126 µM 0.312245673611338 0.333560874518321 no 1108 0.377426911747707 1895 691789
SGTC_2337 9009472 200 µM 0.31214334171221 0.333599896081218 no 1109 0.377465794478162 1852 5742383
SGTC_2769 toremifene 3.73 µM 0.311418396868378 0.333876386151009 no 1110 0.377741285039058 1786 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_890 0929-0006 47.2 µM 0.310718411010083 0.334143442611418 no 1111 0.378007349816883 1719 1378169
SGTC_900 1112-0045 141 µM 0.309184920401931 0.334728788655783 no 1112 0.378590432045166 1839 56211 YIL048W NEO1
SGTC_2680 butyl paraben 22.24 µM 0.306950360464035 0.335582457805508 no 1113 0.379440577990223 1797 7184 An antifungal and steroid mimetic.
SGTC_1015 4130-4525 82 µM 0.30677794006774 0.335648362938725 no 1114 0.379506200207822 1721 1363237
SGTC_2972 9093619 59.92 µM 0.304985644037863 0.33633374056604 no 1115 0.380188543085878 1696 25236256
SGTC_2114 5491910 81.25 µM 0.304534316050182 0.33650641517511 no 1116 0.380360426505992 1831 2849228
SGTC_1802 st050112 57.9 µM 0.303932509408003 0.336736715401128 no 1117 0.380589654856318 1795 4662563
SGTC_2466 5983409 37.09 µM 0.302359788030516 0.337338855611969 no 1118 0.38118890273822 1762 2879657
SGTC_525 k781-2675 26.7 µM 0.301960981771095 0.337491610944802 no 1119 0.381340903684336 1792 3651118 YDL195W SEC31
SGTC_1668 st014914 51.6 µM 0.30004051961526 0.338227582970829 no 1120 0.382073124217431 1799 2839556
SGTC_2532 xanthone 78.9 µM 0.298163065511359 0.338947671213803 no 1121 0.382789354923272 1846 7020 An insecticide.
SGTC_2983 9022671 12.99 µM 0.298040763792498 0.338994599890895 no 1122 0.382836025792628 1941 6405161
SGTC_1578 josamycin 24.2 µM 0.297509799114558 0.339198366544837 no 1123 0.383038663946671 1714 5282165 A P450 substrate.
SGTC_536 3852-0578 10.6 µM 0.296568735949894 0.339559630950487 no 1124 0.38339789131727 1901 2869208
SGTC_1702 st027038 51 µM 0.295275143436781 0.340056468357627 no 1125 0.383891851556515 1815 5521182
SGTC_2198 6589944 200 µM 0.294246976096214 0.340451560675146 no 1126 0.384284593435975 1852 5290268
SGTC_1162 k048-0130 20.1 µM 0.293462515565313 0.34075312198122 no 1127 0.384584323534253 1784 6797406
SGTC_423 5-fluorouracil 457 µM 0.293194273782032 0.340856262508504 no 1128 0.384686830365299 1672 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2815 7968870 71.43 µM 0.292107296291235 0.341274333394924 no 1129 0.385102294112745 1743 2977326 YHR190W ERG9
SGTC_1581 himbacine 57.9 µM 0.290796840456481 0.341778617121182 no 1130 0.38560335096308 1755 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1442 4112-3290 3 µM 0.290187340434363 0.342013258479422 no 1131 0.385836460302299 1808 704353
SGTC_439 amiodarone 34.4 µM 0.28991250258466 0.342119083738499 no 1132 0.385941588261972 1855 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_933 2914-0560 114 µM 0.288751779867052 0.342566152270738 no 1133 0.386385667492613 1959 463887
SGTC_657 3534-0529 86.7 µM 0.287424665798285 0.343077579085907 no 1134 0.386893588520184 1899 1049549
SGTC_3201 9113999 49.47 µM 0.287123225391069 0.343193784578433 no 1135 0.387008984630304 1853 16649224
SGTC_2728 chlorpromazine 9.18 µM 0.287086980686427 0.343207757936911 no 1136 0.387022860343897 1832 2726 A thorazine and dopamine antagonist.
SGTC_1988 st071872 53.4 µM 0.286906006624173 0.343277531762246 no 1137 0.387092145569617 1935 16414116
SGTC_90 0870-0863 4.608 µM 0.286299231083623 0.343511510616656 no 1138 0.387324473498429 1759 1738164
SGTC_195 4234-0266 16.654 µM 0.285135838643234 0.343960294319213 no 1139 0.387770036963009 1808 2303354
SGTC_2174 5790901 200 µM 0.28343905465488 0.344615230283091 no 1140 0.388420147007122 1802 786020
SGTC_1260 0700-1617 7.75 µM 0.282190735970163 0.345097362314546 no 1141 0.388898630707937 1823 2853078
SGTC_2141 5621638 7.665 µM 0.281882970155863 0.34521626788808 no 1142 0.389016624052457 1925 2856238
SGTC_1331 1472-0049 76.2 µM 0.280682929989092 0.345680050251641 no 1143 0.389476801269652 1761 24051409
SGTC_2497 7-hydroxyflavone 100 µM 0.277809960555427 0.346791313808917 no 1144 0.390579122319245 1916 5281894
SGTC_116 0155-0182 31.788 µM 0.277731785679176 0.346821570303927 no 1145 0.390609129342356 1797 771486
SGTC_2380 9035439 200 µM 0.275578256977129 0.347655447055785 no 1146 0.391436005818795 1890 6462575
SGTC_2117 5521686 200 µM 0.274149763883697 0.348208986971873 no 1147 0.391984766079698 1775 803312
SGTC_2489 cantharidin 73.42 µM 0.27387942358268 0.348313780061019 no 1148 0.392088642404274 1744 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2188 6126565 140.678 µM 0.272506016989168 0.348846337849698 no 1149 0.392616482695864 1908 874518
SGTC_3016 9080866 49.47 µM 0.27216912175742 0.348977019274504 no 1150 0.392745991593134 1797 17066299
SGTC_1515 3460-0031 42.1 µM 0.27204794879913 0.349024026561507 no 1151 0.392792575674029 1886 2876596
SGTC_456 gingerol 170 µM 0.269696351185536 0.349936752663113 no 1152 0.3936969339494 1861 442793 A herb.
SGTC_3021 9087658 49.47 µM 0.268507021886592 0.350398698072055 no 1153 0.394154535288382 1947 25237042
SGTC_335 4077-0256 27.6 µM 0.267368404930135 0.350841153818997 no 1154 0.39459276170788 1904 3121989
SGTC_399 oxolinic acid 75 µM 0.264976093729125 0.351771441887042 no 1155 0.395513939094067 1834 4628 A DNA gyrase inhibitor.
SGTC_1924 st058459 75.1 µM 0.262443399509992 0.352757288088739 no 1156 0.396489808455765 1883 688683
SGTC_2225 6654152 15.4 µM 0.262304697899734 0.352811306054734 no 1157 0.396543270199741 1910 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1421 4029-0249 71.4 µM 0.260008920335773 0.35370583725017 no 1158 0.397428446377074 1980 2894095
SGTC_564 3555-0129 330 µM 0.259808698716844 0.35378389038285 no 1159 0.397505670356128 1972 563260
SGTC_2023 5144124 124 µM 0.259401866278386 0.353942506304105 no 1160 0.39766259495226 1834 2830192
SGTC_567 1080-0542 68.4 µM 0.259246149330072 0.354003223972757 no 1161 0.397722662932246 1954 5950415
SGTC_52 0329-0193 875 nM 0.258959910018176 0.354114845038202 no 1162 0.397833086378793 1932 3739292
SGTC_3154 9100113 49.47 µM 0.258552175063428 0.354273865843898 no 1163 0.397990393716708 1800 25237525
SGTC_2164 5685496 200 µM 0.258364974657477 0.354346884432128 no 1164 0.398062622655548 1934 759046
SGTC_1923 st058458 19.1 µM 0.257832430783001 0.354554635488371 no 1165 0.398268117156283 1971 3534982
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.257271652716412 0.354773447783076 no 1166 0.398484536980407 1860 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_297 0986-0032 24 µM 0.256960377723222 0.354894926137017 no 1167 0.3986046801227 1848 2847425
SGTC_1654 st012436 41.8 µM 0.255733523855242 0.355373862387138 no 1168 0.399078303701775 1957 4323132
SGTC_665 3914-0008 307 µM 0.255007893751916 0.355657239706932 no 1169 0.399358501207547 1810 1069549
SGTC_468 gf-109203x 121 µM 0.254094659466868 0.356013994705442 no 1170 0.3997112145676 1965 2396 A protein kinase C inhibitor.
SGTC_1434 4073-0095 163 µM 0.252426728420892 0.356665897316595 no 1171 0.400355621308177 1948 24133745
SGTC_1455 4262-0120 131 µM 0.250954328854834 0.357241725631247 no 1172 0.400924709847906 1938 1529587
SGTC_3009 9080819 71.4286 µM 0.250199441907956 0.357537074208878 no 1173 0.40121655841316 1839 17027216
SGTC_1280 0880-0253 10.1 µM 0.250097868486553 0.357576821201316 no 1174 0.401255832156693 1864 6836607
SGTC_1386 3228-0095 33.8 µM 0.249037102359718 0.357992004926317 no 1175 0.401666040893844 1947 870181
SGTC_937 3122-0005 46.7 µM 0.248334283463224 0.358267180726019 no 1176 0.401937887620887 1984 759535
SGTC_1062 mesoridazine 14.2 µM 0.248261789386308 0.35829556863865 no 1177 0.401965930658002 1875 4078 A neuroleptic.
SGTC_2361 9034121 116 µM 0.248056929649585 0.358375793775298 no 1178 0.40204517971116 1847 6496917
SGTC_2781 5567276 71.43 µM 0.246144399722886 0.359125060953226 no 1179 0.40278522705919 1925 2853274
SGTC_2044 5102272 200 µM 0.245973978863361 0.359191852668392 no 1180 0.402851187812959 1871 592666
SGTC_753 1322-0200 289 µM 0.24521484922686 0.359489424669769 no 1181 0.403145039653923 1894 5403907
SGTC_2533 agelasine 13.65 µM 0.243850232540342 0.360024556364408 no 1182 0.403673407206861 2032 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_194 1486-1323 56.904 µM 0.243514159829369 0.360156388760673 no 1183 0.403803558620664 1832 5178754
SGTC_1316 1272-0050 65.9 µM 0.243083072446126 0.360325517237497 no 1184 0.403970522110721 1880 7340392
SGTC_659 k018-0002 107 µM 0.242178798511887 0.360680379732438 no 1185 0.404320811236944 2003 6797879 YHR007C ERG11
SGTC_930 2810-3379 265 µM 0.237109649774504 0.362671870131517 no 1186 0.406285863185965 2013 1015764
SGTC_2176 5809774 33.9695 µM 0.235257591190765 0.363400409811029 no 1187 0.407004404373311 2024 2870539
SGTC_3080 9117754 49.47 µM 0.235051760607642 0.363481407447496 no 1188 0.407084279621725 1992 9550191
SGTC_186 3455-3465 67.277 µM 0.234615903480247 0.363652944361504 no 1189 0.407253432429628 1911 755278
SGTC_2379 9035213 200 µM 0.234418116465468 0.363730794884159 no 1190 0.407330197760713 2028 646551
SGTC_2523 spermine 47.74 µM 0.234301631318844 0.363776646985613 no 1191 0.407375409779737 2014 1103 A DNA binding polyamine.
SGTC_2598 perillyl alcohol 100 µM 0.234159584116359 0.363832563730792 no 1192 0.407430545009553 1944 10819 An apoptosis inducer.
SGTC_455 paf C-16 10 µM 0.233470860040389 0.364103720401523 no 1193 0.407697897343045 1883 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2621 lithochol-11-enic acid 100 µM 0.233159058938118 0.364226501597966 no 1194 0.407818947988997 2027 6708711
SGTC_3291 9121177 71.43 µM 0.232724799673938 0.36439752764977 no 1195 0.407987555269508 1865 17015612
SGTC_3271 9137798 49.47 µM 0.232641163937636 0.364430469346012 no 1196 0.408020029980983 1998 6498326
SGTC_2490 carminic acid 95.39 µM 0.232099988282511 0.364643646967397 no 1197 0.40823017698923 1924 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1715 st032160 10.2275 µM 0.232043345283037 0.364665961958981 no 1198 0.408252173882804 1975 5289825
SGTC_2328 6201408 200 µM 0.231665447134064 0.364814849881313 no 1199 0.408398935254034 1862 2890418
SGTC_2859 9028643 45.46 µM 0.230880780946882 0.365124065258839 no 1200 0.408703710986869 1980 17151580
SGTC_3073 9114972 49.47 µM 0.230813152135716 0.365150720023288 no 1201 0.408729981585697 2019 41905075
SGTC_2805 7950783 58.44 µM 0.230698971138619 0.365195724031494 no 1202 0.408774336440545 1902 1178958 YDL195W SEC31
SGTC_438 sphingosine 6.67 µM 0.229592914950651 0.365631767909719 no 1203 0.409204056436605 1723 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_289 k017-0060 526 µM 0.22861065673173 0.366019152179666 no 1204 0.409585770514213 1913 5512909
SGTC_1085 doxorubicin 7.67 µM 0.228113684016776 0.366215200996947 no 1205 0.409778931109283 2006 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2446 5162541 200 µM 0.227462854573923 0.366471996965436 no 1206 0.410031924994058 1864 1549321
SGTC_1790 st045711 43.5 µM 0.227419460275631 0.366489121060928 no 1207 0.41004879478971 2021 585119
SGTC_1560 lithocholic acid 53.1 µM 0.227403487545905 0.366495424226645 no 1208 0.410055004326819 2014 9903 A bile acid which acts as a detergent.
SGTC_3086 9117350 49.47 µM 0.227236596532971 0.366561284985958 no 1209 0.410119886003167 1928 2679265
SGTC_663 1486-0733 13.9 µM 0.22688095028415 0.366701647963105 no 1210 0.410258157645387 1909 722445 YPR165W RHO1
SGTC_2076 5212012 200 µM 0.226641553252326 0.366796140878238 no 1211 0.410351239059106 1949 604802
SGTC_233 rapamycin 362 pM 0.226217667460922 0.366963473544432 no 1212 0.410516065052925 2017 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_311 1315-0136 58 µM 0.226180390348137 0.366978190224212 no 1213 0.410530560839215 1993 6759207
SGTC_1257 0669-0121 16 µM 0.224677112402877 0.367571833955378 no 1214 0.411115235534477 1988 4307855
SGTC_279 1273-0055 2.93 µM 0.224318688978622 0.367713421983234 no 1215 0.411254667509045 2033 2847562
SGTC_119 0121-0043 24.815 µM 0.223597321790234 0.367998438200797 no 1216 0.411535323906511 2018 1092378
SGTC_664 1222-0054 14.9 µM 0.2229593926391 0.368250548149446 no 1217 0.411783555478147 1909 6813991
SGTC_2543 pimpinellin 60.67 µM 0.222633628814087 0.368379312084529 no 1218 0.411910330619373 1858 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_163 TUB2.036 7.546 µM 0.221403411714163 0.368865710457794 no 1219 0.412389168090906 2034 15992207 YJR013W GPI14
SGTC_2061 5245884 80.95 µM 0.221273352747134 0.368917144951868 no 1220 0.412439798586098 1891 573863
SGTC_642 0335-0876 158 µM 0.221200475058337 0.368945966959498 no 1221 0.41246816968891 1918 6812350
SGTC_1735 st034310 56.75 µM 0.220631092314536 0.369171174457664 no 1222 0.412689844707839 1966 871153
SGTC_2161 5662504 8.5105 µM 0.220353953440868 0.369280807228649 no 1223 0.412797751920623 1894 2859334
SGTC_557 1315-0110 16.2 µM 0.219673209534888 0.36955014636358 no 1224 0.413062835359469 1894 6833801
SGTC_1911 st060208 74.3 µM 0.218972470579403 0.369827463499367 no 1225 0.413335746328754 1984 688783
SGTC_538 2922-0838 53.3 µM 0.218617803542722 0.369967848641665 no 1226 0.413473891518309 2031 777039
SGTC_2914 7968218 45.32 µM 0.216818983981219 0.370680128104213 no 1227 0.414174708392962 1997 2977111
SGTC_1904 st060225 78 µM 0.216794342651667 0.370689888428015 no 1228 0.414184310513836 1884 66595
SGTC_1366 1683-0113 21.9 µM 0.215846220286333 0.371065498733906 no 1229 0.414553809416385 1892 708623
SGTC_1423 4048-0112 5.59 µM 0.214778740131163 0.371488541124393 no 1230 0.414969914504648 2018 X1423
SGTC_1275 0867-0008 21.1 µM 0.213596593693331 0.371957206943282 no 1231 0.415430827969278 1939 3422836
SGTC_1269 0831-0796 3.05 µM 0.212109358775498 0.372547095594827 no 1232 0.41601085928755 2024 927758
SGTC_2839 9003951 25.97 µM 0.211545747077054 0.372770721654604 no 1233 0.416230719409433 2110 2990634
SGTC_2656 pseudo-anisatin 100 µM 0.211101413676058 0.372947051510647 no 1234 0.416404068567437 1950 6708809 A neurotoxin.
SGTC_2940 9060638 45.86 µM 0.210853804504314 0.37304532461596 no 1235 0.41650067615374 1920 4027022
SGTC_2922 7999257 32.47 µM 0.209583942921468 0.373549447115624 no 1236 0.416996206501567 1974 2988377
SGTC_1627 st003713 25.6 µM 0.209574774639703 0.373553087620966 no 1237 0.416999784664802 1898 16195070 YER133W GLC7
SGTC_2045 5106652 78.05 µM 0.209215058518002 0.373695931190372 no 1238 0.417140178771503 2017 673349
SGTC_3043 9092303 49.47 µM 0.207999685139041 0.374178685214332 no 1239 0.417614606600056 1863 25236084
SGTC_686 1319-0111 510 µM 0.207365301430049 0.37443074489853 no 1240 0.417862289533084 2028 4562600
SGTC_3114 9122766 49.47 µM 0.206672303436518 0.374706155138419 no 1241 0.418132894523934 1892 17176985
SGTC_1233 0325-0408 14.2 µM 0.204423151397946 0.375600449550964 no 1242 0.419011419979359 2012 12874
SGTC_1070 indatraline 8.81 µM 0.203864033338937 0.375822866715581 no 1243 0.419229876018147 1910 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2268 7933382 153.85 µM 0.203530796875848 0.375955447811849 no 1244 0.419360088485585 2064 935025 YOR257W CDC31
SGTC_1891 st059073 26.2 µM 0.203133872989474 0.376113386625058 no 1245 0.419515198398565 2078 688754
SGTC_2679 rapamycin 1 nM 0.202711675919336 0.376281404591189 no 1246 0.419680198292215 1964 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_45 0kpi-0036 14.9 µM 0.202447571158265 0.376386519908513 no 1247 0.419783420916722 1962 2795021
SGTC_2128 5255449 168.493 µM 0.201508224327307 0.376760459963706 no 1248 0.420150599623503 1958 736008
SGTC_3150 9097574 49.47 µM 0.201233971729885 0.376869657686559 no 1249 0.420257814592424 2051 17217476
SGTC_2716 st080858 38.6235 µM 0.199642213937004 0.377503633806847 no 1250 0.420880205189744 2039 5296050
SGTC_1947 st076332 61.6 µM 0.198478062113796 0.377967509283306 no 1251 0.421335523608387 2051 24208416
SGTC_615 k087-0205 167 µM 0.197582540329967 0.378324464504349 no 1252 0.421685848148278 1917 9642773
SGTC_1205 4161-2785 76 µM 0.196389205542124 0.378800289448935 no 1253 0.422152772241082 1851 3498106
SGTC_3028 9087778 49.47 µM 0.195895673773886 0.378997131842403 no 1254 0.422345911747477 1944 17217395
SGTC_1899 st063254 59.6 µM 0.195230240452889 0.37926258588945 no 1255 0.422606353035241 1886 3093813
SGTC_3198 9112019 49.47 µM 0.194476954703539 0.379563154651606 no 1256 0.42290121936047 1979 45595555
SGTC_3264 9137442 49.47 µM 0.193938968462676 0.379777861265831 no 1257 0.42311183525601 2063 17015726
SGTC_2961 9083290 32.55 µM 0.193704154309513 0.379871585606081 no 1258 0.423203769394015 2055 17741490
SGTC_2046 4110841 106 µM 0.193262736620714 0.380047793323662 no 1259 0.423376604000352 2100 44119630 YMR134W ERG29
SGTC_2444 5485484 36.41 µM 0.191225829784957 0.380861219870683 no 1260 0.424174333883038 2021 6790631
SGTC_1751 st044839 27.194 µM 0.190152554140607 0.381290038246505 no 1261 0.424594794508459 2094 5291326
SGTC_943 3253-1379 105 µM 0.19014340196309 0.381293695550697 no 1262 0.424598380285401 2011 668464
SGTC_2673 kobusone 100 µM 0.189249185303469 0.381651084789662 no 1263 0.424948759902556 2017 6710676 An epoxy ketone and protein crosslinker.
SGTC_2871 9038510 12.99 µM 0.189190473572907 0.381674553487432 no 1264 0.424971766912296 2095 4945164
SGTC_1763 st044482 94.5 µM 0.189139159198416 0.381695065614201 no 1265 0.42499187537427 2017 88505
SGTC_1145 3546-0597 10.2 µM 0.188708983802851 0.381867034629224 no 1266 0.425160455022711 1982 875334
SGTC_1853 st056710 91.2 µM 0.188038715040328 0.38213503099323 no 1267 0.42542315112651 2117 269167
SGTC_1742 st038235 28.8875 µM 0.18726530986765 0.3824443349995 no 1268 0.425726310263202 1961 564103 YBR002C RER2
SGTC_262 fenpropimorph 62.5 µM 0.186047248594468 0.382931620100885 no 1269 0.426203854537772 2028 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2817 7995342 71.43 µM 0.185947786866513 0.382971417934849 no 1270 0.426242853570914 1931 18879975
SGTC_2531 methyl deoxycholate 70.07 µM 0.185835812818051 0.383016223828713 no 1271 0.426286759559277 1950 16667744 Haematoxylin.
SGTC_2197 6588183 93.1375 µM 0.184201528364933 0.383670352989045 no 1272 0.426927680267577 1998 884136
SGTC_38 0929-0051 58.268 µM 0.182625272475665 0.384301570221165 no 1273 0.427546026626967 2096 1379719
SGTC_286 k060-0067 22.9 µM 0.181705079001967 0.384670206957285 no 1274 0.427907089931758 2002 5985051
SGTC_1893 st059353 36.1 µM 0.180257039793608 0.385250513932809 no 1275 0.428475390222859 1941 3112488
SGTC_2452 5863136 48.41 µM 0.179527522517297 0.385542968086544 no 1276 0.428761754265856 2022 2184096
SGTC_1545 lovastatin 49.4 µM 0.17845829298957 0.385971726108375 no 1277 0.429181536375757 1997 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2744 captopril 92.04 µM 0.177862827986612 0.386210566328822 no 1278 0.429415352141117 2100 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1357 1503-1303 39.5 µM 0.177196971874402 0.38647769140215 no 1279 0.429676837061417 2010 292895
SGTC_3241 9133421 49.47 µM 0.176459314848334 0.386773684052663 no 1280 0.429966554567406 2090 17018221
SGTC_20 0481-0013 4.944 µM 0.176334841557959 0.386823636771602 no 1281 0.430015445632375 1955 182045
SGTC_88 0180-0332 8.668 µM 0.174913068571736 0.387394345230457 no 1282 0.430573970672432 2064 3101745
SGTC_3005 9076496 71.4286 µM 0.174809096697471 0.387436089749932 no 1283 0.430614820136024 2117 21368410
SGTC_2238 6671620 73.2395 µM 0.174014990286266 0.387754964935881 no 1284 0.430926840711377 2112 729941
SGTC_77 0828-0286 12.516 µM 0.173867034640475 0.387814385226957 no 1285 0.430984980267835 2120 745345
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.173504508855118 0.387959989879143 no 1286 0.431127442039061 2072 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2539 epi(13)torulosol 80 µM 0.172146174660859 0.388505690396647 no 1287 0.431661306219922 1962 6708597
SGTC_2326 6164455 177.58 µM 0.172109014425891 0.388520622339068 no 1288 0.431675913013724 1973 2888790
SGTC_704 1310-0270 142 µM 0.17139693417266 0.388806786381032 no 1289 0.431955832643226 1956 5718033
SGTC_632 0781-2353 4.65 µM 0.170827293845192 0.389035751472999 no 1290 0.432179783566005 2029 6811515 YHR007C ERG11
SGTC_1344 1488-0097 29.1 µM 0.170498373680065 0.389167977429961 no 1291 0.432309106627081 2033 747966
SGTC_2987 9018338 71.43 µM 0.17027183810632 0.389259052230915 no 1292 0.432398178883804 2131 5055682
SGTC_2056 5235370 200 µM 0.170233498220631 0.389274466736448 no 1293 0.43241325420784 1978 5511916
SGTC_3061 glucosamine 200 µM 0.170171486303716 0.389299398922857 no 1294 0.43243763763282 2121 91431 and experimental redox chemotherapeutic
SGTC_1622 st003707 19.4 µM 0.169349818481109 0.389629797370505 no 1295 0.432760746173023 2017 10140899
SGTC_2052 5265182 7.135 µM 0.168479385092234 0.389979891822344 no 1296 0.433103080081225 2087 1239884
SGTC_85 0868-0259 160.055 µM 0.168107050927176 0.390129674526646 no 1297 0.433249531227715 2022 83173
SGTC_2771 fluoxetine 41.05 µM 0.167392724881797 0.390417079483357 no 1298 0.433530524559285 2080 3386 A selective serotonin reuptake inhibitor.
SGTC_2876 9059903 25.97 µM 0.167331876852949 0.390441564106532 no 1299 0.433554461809262 2114 6916095
SGTC_2995 9067767 71.4286 µM 0.166963237595968 0.390589910052192 no 1300 0.433699487492258 2001 11673567
SGTC_2722 naftopidil 47.16 µM 0.16485032121439 0.391440485825652 no 1301 0.434530897612841 2094 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_224 benfluorex 43.875 µM 0.16436337082229 0.391636586395731 no 1302 0.434722548611743 2112 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2838 9002687 71.43 µM 0.162667205059567 0.392319866745823 no 1303 0.435390234792899 1920 6457060
SGTC_763 3453-1109 128 µM 0.161221150361373 0.392902655170161 no 1304 0.435959611720144 2132 1560353
SGTC_734 2023-0417 80 µM 0.158363770367379 0.394054940355229 no 1305 0.437085080271504 2070 3935732
SGTC_623 k072-0108 16.9 µM 0.15834087568584 0.394064176770774 no 1306 0.437094100127546 2037 5382803
SGTC_563 tetrahydrosecaminediol 614 µM 0.158244413197243 0.394103093346572 no 1307 0.437132103974847 2123 334274 A psychoactive constituent of the cannabis plant.
SGTC_2918 7977171 22.06 µM 0.156540100318666 0.394790850939721 no 1308 0.437803656673737 2065 2236483
SGTC_444 curcumin 90.4 µM 0.156033981551224 0.394995153123178 no 1309 0.438003117926716 2076 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1377 2944-0135 198 µM 0.155797851216722 0.395090480439958 no 1310 0.438096182212139 2033 1894137
SGTC_691 1548-0686 185 µM 0.155516907754743 0.39520390728097 no 1311 0.438206912820508 1992 46495133
SGTC_2130 NSC 7 2.4545 µM 0.15250714936328 0.396419608793075 no 1312 0.439393476010271 2113 21448
SGTC_443 clozapine 122 µM 0.151969430467047 0.396636910637933 no 1313 0.43960552326139 2164 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2969 9091408 28.7 µM 0.151877124569302 0.396674216336451 no 1314 0.439641925459569 1889 4286311
SGTC_2186 6124449 200 µM 0.151842025427041 0.396688402005652 no 1315 0.439655767460209 2102 3834182 YLR033W RSC58
SGTC_147 4466-0538 29.23 µM 0.151773367824489 0.396716151057346 no 1316 0.439682844078126 2035 6742687 YHR072W ERG7
SGTC_2675 theaflavin digallate 100 µM 0.15163678115048 0.3967713562686 no 1317 0.439736710840748 2092 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.151152778654835 0.396966995661787 no 1318 0.439927599692481 2089 97141
SGTC_3272 9137413 49.47 µM 0.150248454978603 0.397332603183599 no 1319 0.44028429910336 2170 17614870
SGTC_272 doxorubicin 8.13 µM 0.149778259038939 0.397522733593503 no 1320 0.440469781309724 2136 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1600 coumarin 106 71.1 µM 0.147444801808526 0.398466659602688 no 1321 0.44139047259797 2091 100336 A hepatotoxic, DNA x-linker.
SGTC_3170 9103054 49.47 µM 0.147123991323705 0.39859647989203 no 1322 0.441517076796725 2037 16432970
SGTC_597 k018-0003 82.8 µM 0.146808458916547 0.398724175282327 no 1323 0.441641603891458 2108 6786234
SGTC_1805 st050013 60.3 µM 0.146604485444065 0.39880672874575 no 1324 0.441722106534696 2108 4037144
SGTC_953 1188-0045 9.7 µM 0.146547730261945 0.398829699875516 no 1325 0.441744506651114 2077 6144426
SGTC_877 0771-0151 33.1 µM 0.146281144670796 0.39893760259078 no 1326 0.441849725055299 2060 6166523
SGTC_1646 st011709 75.6 µM 0.145896003101644 0.399093505453308 no 1327 0.442001743445823 2154 5757843
SGTC_409 arachidonic acid 100 µM 0.141702025042209 0.400792238148912 no 1328 0.443657687665923 2085 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_318 1488-0629 67.2 µM 0.141534358727234 0.400860189112987 no 1329 0.443723909444699 2041 3662576
SGTC_2008 4012253 172 µM 0.140732478622037 0.401185212509593 no 1330 0.444040643101558 2070 603940
SGTC_2828 7998861 71.43 µM 0.140150693969584 0.40142106817437 no 1331 0.444270463907274 2175 2988188
SGTC_520 3584-0023 682 µM 0.139653635276795 0.401622604369314 no 1332 0.444466830495841 1975 1340790
SGTC_522 1273-0010 11.6 µM 0.138779482433761 0.401977099679569 no 1333 0.444812203860556 2076 5705015
SGTC_2584 androsterone 48.74 µM 0.13875542948845 0.401986855014949 no 1334 0.444821707651052 2170 2754130 A steroid.
SGTC_171 k064-0041 9.68 µM 0.138575544732931 0.402059814174546 no 1335 0.4448927846517 2022 53325
SGTC_2218 6965428 192.983 µM 0.138225727192 0.402201705860132 no 1336 0.445031011449808 2126 675684
SGTC_2470 5664817 21.68 µM 0.137043076421245 0.402681503589105 no 1337 0.445498373118584 2195 2859561
SGTC_394 menadione 8.33 µM 0.136687359073945 0.402825845720973 no 1338 0.445638960870828 2164 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_638 3970-0837 4.09 µM 0.136550763027082 0.402881276857922 no 1339 0.445692948616527 2040 4118451 YLR208W SEC13
SGTC_229 benomyl 22.8748 µM 0.136269754217283 0.402995317319069 no 1340 0.445804016725188 2076 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1226 3909-7979 35.4 µM 0.13567766931045 0.403235627304683 no 1341 0.446038050882381 2145 6615510
SGTC_2806 7952793 58.44 µM 0.135187774023795 0.403434489139816 no 1342 0.44623170663533 2096 2972490
SGTC_3219 9131112 49.47 µM 0.135091221875403 0.40347368523299 no 1343 0.446269875242835 2181 17612988 YMR079W SEC14
SGTC_3301 9125354 19.7965 µM 0.134970685554671 0.403522619247625 no 1344 0.446317525875691 2114 41905162
SGTC_3106 9121286 49.47 µM 0.134969182931208 0.403523229275765 no 1345 0.446318119900366 2151 15943471
SGTC_795 0685-0265 78 µM 0.134148939596671 0.403856262877133 no 1346 0.446642400573033 2207 302754
SGTC_2626 ethyl orsellinate 100 µM 0.134094992819486 0.403878168688267 no 1347 0.446663729517995 2082 75653 A natural product.
SGTC_981 1488-1094 54.9 µM 0.133721874621494 0.404029686577796 no 1348 0.44681125353371 2122 3449522
SGTC_2927 9011802 47.9 µM 0.131975783379205 0.404738939924935 no 1349 0.447501723122275 2026 43912568
SGTC_199 4063-0024 41.6 µM 0.131540082031475 0.404915968488795 no 1350 0.447674040571194 2153 306215
SGTC_1845 st056753 3.01 µM 0.131409790178276 0.404968910779237 no 1351 0.447725572190968 2110 5375839
SGTC_42 0133-0086 60.653 µM 0.131357860353982 0.404990012229122 no 1352 0.447746111157457 2140 162923 Model of phenazepam hydroxylation.
SGTC_2753 fluvastatin 17.09 µM 0.131076310880148 0.40510442339553 no 1353 0.447857470320931 2099 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_359 0081-0058 15.9 µM 0.129845763378306 0.40560456690615 no 1354 0.448344227715789 2149 3494159
SGTC_1669 st015249 58.4 µM 0.129567184736112 0.405717813788236 no 1355 0.448454433565295 2217 722793
SGTC_1954 st077032 68.9 µM 0.128585324641855 0.406117019215849 no 1356 0.448842889568501 1945 698907
SGTC_1373 2887-0003 58.5 µM 0.127648742514014 0.406497906480543 no 1357 0.449213477837143 2085 776948
SGTC_2242 6630449 61.2675 µM 0.125742962565371 0.407273217942765 no 1358 0.449967696269392 2105 691249 YDR170C SEC7
SGTC_2786 7743617 45.45 µM 0.125029351336594 0.40756362372088 no 1359 0.450250156826016 2031 583674
SGTC_228 caffeine 993.056 µM 0.124769623796853 0.407669333076919 no 1360 0.450352968065497 2196 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2814 7977482 42.97 µM 0.122865746402066 0.408444417774288 no 1361 0.45110670523697 2150 6456762
SGTC_25 0118-0223 35.662 µM 0.122382618626404 0.408641160321623 no 1362 0.451298001678871 2172 5333628
SGTC_1325 1431-0015 227 µM 0.120728066269161 0.409315112442568 no 1363 0.451953213959699 1987 1103340
SGTC_1657 st012939 43.4 µM 0.120478076912333 0.409416964471832 no 1364 0.452052222613461 2172 24207257
SGTC_2364 9055074 200 µM 0.118645263291522 0.410163885731432 no 1365 0.45277820183588 2081 6470630
SGTC_2664 lyso-paf C-16 73.48 µM 0.118230814217888 0.410332830264415 no 1366 0.452942387482648 2194 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_708 3448-5400 146 µM 0.117106782246786 0.410791110310033 no 1367 0.453387717632084 2208 3462195
SGTC_2104 5389443 200 µM 0.114859720567413 0.411707626317836 no 1368 0.45427815603002 2172 2244536
SGTC_739 1486-1183 203 µM 0.114538687402986 0.411838606569486 no 1369 0.454405390034071 2211 4346692
SGTC_1310 1188-0297 994 nM 0.113804002925981 0.412138391849749 no 1370 0.454696582668058 2138 1588352
SGTC_2955 9076254 12.21 µM 0.111634993475244 0.413023746651863 no 1371 0.455556412326997 2198 16459619
SGTC_2298 7976326 193.81 µM 0.111389613684415 0.413123934687946 no 1372 0.455653697942754 2156 2235818
SGTC_1833 st055984 71 µM 0.11067828080716 0.413414402311405 no 1373 0.455935734776713 2084 676288
SGTC_1834 st055981 52.8 µM 0.109838144066335 0.41375752709254 no 1374 0.456268869727773 2197 471719 YDL150W RPC53
SGTC_776 4476-4378 112 µM 0.108841605007947 0.414164614360615 no 1375 0.456664061899102 2065 2892008
SGTC_413 propylparaben 100 µM 0.108642249938249 0.414246062204701 no 1376 0.456743124232081 2077 7175 A pharmaceutical preservative.
SGTC_2345 9052315 157.45 µM 0.107980893566337 0.414516290156968 no 1377 0.457005424153064 2099 6469265
SGTC_723 4182-0001 115 µM 0.107641856017161 0.414654835437204 no 1378 0.45713989678275 2079 744821 YLR208W SEC13
SGTC_839 0122-0028 230 µM 0.106533416223373 0.415107865478087 no 1379 0.457579571972697 2141 759448
SGTC_2306 7482397 179.52 µM 0.106329114040275 0.415191378092097 no 1380 0.457660616428848 2198 891448
SGTC_1606 st000094 49.2 µM 0.105468895135798 0.415543051810052 no 1381 0.458001875194708 2233 1242210
SGTC_1572 epiandrosterone 68.9 µM 0.104758740156046 0.415833427562252 no 1382 0.458283625212548 2137 441302 A steroid.
SGTC_68 0986-0284 82.829 µM 0.103012362934591 0.416547700094223 no 1383 0.458976579476056 1930 423278 YIL048W NEO1
SGTC_2066 5222451 176 µM 0.102653723268145 0.416694418782201 no 1384 0.459118901507056 2224 2281147
SGTC_2976 9009005 19.48 µM 0.102492666902601 0.416760310359553 no 1385 0.45918281658121 2224 2993148
SGTC_150 3970-0969 77.2 µM 0.102285902098209 0.416844905657516 no 1386 0.459264872554776 2115 6615640
SGTC_3166 9102297 49.47 µM 0.101786950158513 0.417049061608707 no 1387 0.459462892056278 2118 25237072
SGTC_1512 0259-0544 12.2 µM 0.101263777847067 0.417263151823229 no 1388 0.459670534718651 2123 18476
SGTC_3023 9089636 49.47 µM 0.10095479606015 0.417389603483936 no 1389 0.459793172145382 2254 17249241
SGTC_1072 oxiconazole 14.9 nM 0.0993001568293178 0.418066914297981 no 1390 0.460449976950936 2242 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2721 ifenprodil 61.44 µM 0.0987110927746789 0.418308100834262 no 1391 0.460683830561768 2214 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2204 7233102 200 µM 0.0979673804038628 0.418612650481927 no 1392 0.460979097700904 2182 2172480
SGTC_990 3985-0011 41.3 µM 0.0964172778888113 0.419247572895664 no 1393 0.461594585141167 2187 5399565 YGL099W LSG1
SGTC_466 geldanamycin 89.2 µM 0.0955555614408304 0.419600623261181 no 1394 0.461936780230014 2250 5288382 HSP90 inhibitor.
SGTC_3050 9093513 49.47 µM 0.0941071892919965 0.420194175653742 no 1395 0.462512004749977 2216 25236664
SGTC_624 k048-0052 28 µM 0.0934296092881093 0.420471914791051 no 1396 0.46278113428975 2136 6835531
SGTC_3258 9138477 49.47 µM 0.0921652420999362 0.420990282995027 no 1397 0.463283376628211 2249 4970355
SGTC_2790 5423970 71.43 µM 0.0916506636525946 0.421201290342006 no 1398 0.463487798516175 2226 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2642 cholecalciferol 100 µM 0.0909944275417661 0.421470418471615 no 1399 0.463748509432858 2242 9821465 A vitamin D precursor, similar to steriods.
SGTC_2263 7948595 193.29 µM 0.0889855620847117 0.422294499190671 no 1400 0.464546692192145 2228 2971371
SGTC_2162 5663267 200 µM 0.0877648893159468 0.422795412404956 no 1401 0.465031772155613 2244 6456493
SGTC_1960 st011366 51.8 µM 0.0868887231266996 0.42315503150295 no 1402 0.465379981629872 2246 3972846
SGTC_1505 k297-0037 20.6 µM 0.0864094854949505 0.423351759886967 no 1403 0.465570453400468 2114 4089396
SGTC_923 1900-2434 73.3 µM 0.0863394704550544 0.423380502857139 no 1404 0.465598281360338 2252 5910570
SGTC_104 0074-0074 590.992 µM 0.0862625479916078 0.423412081971964 no 1405 0.465628854917207 2264 3943124
SGTC_3052 9092717 49.47 µM 0.0856938442419511 0.42364556817825 no 1406 0.465854897856023 2180 25237534
SGTC_1203 3992-3522 103 µM 0.0847657488049602 0.424026663270627 no 1407 0.466223811998644 2271 5322312
SGTC_2663 amphotericin b 100 µM 0.0845830234586987 0.424101702442573 no 1408 0.466296448006505 2217 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1563 conessine 56.1 µM 0.0842902658541964 0.424221933908048 no 1409 0.466412825791673 2257 441082 An anti-amoebic, histamine inhibitor.
SGTC_219 mitoxanthrone 164.414 µM 0.0833653398844225 0.424601834392628 no 1410 0.466780523656982 2217 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2432 5630864 12.22 µM 0.082055157775086 0.425140093295895 no 1411 0.467301425865432 2184 5714970
SGTC_1060 3448-7350 82 µM 0.0813459308813857 0.425431521534509 no 1412 0.467583423716664 2254 570178
SGTC_2596 sinensetin 100 µM 0.0805087149238023 0.425775594153645 no 1413 0.467916332614685 2192 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2905 7799065 20.05 µM 0.0788746165737767 0.426447326007038 no 1414 0.468566176682726 2272 1296806
SGTC_2948 9070189 9.45 µM 0.0787452173395204 0.426500527535974 no 1415 0.468617639442195 2270 6473636 YDL196W YDL196W
SGTC_363 0455-0021 3.06 µM 0.0786527413530558 0.426538549166754 no 1416 0.46865441795218 2232 4597466
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0758030203218872 0.427710548931668 no 1417 0.469787906585926 2251 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_251 melphalan 456.522 µM 0.0753140358264393 0.427911717156686 no 1418 0.469982427112705 2211 460612 A DNA alkylator.
SGTC_349 k015-0014 24 µM 0.0752577405822987 0.427934878224402 no 1419 0.470004822108731 2230 2196908
SGTC_379 3970-0972 5.9 µM 0.0743200115306668 0.428320716471644 no 1420 0.470377877082714 2182 2898042 YBL034C STU1
SGTC_111 0083-0039 52.457 µM 0.0741474742500266 0.428391716183137 no 1421 0.470446520104235 2290 759313
SGTC_418 lividomycin a 100 µM 0.0739991533070244 0.428452752637428 no 1422 0.470505529489153 2281 72394 An antibiotic.
SGTC_748 act1.228 77.9 µM 0.0733073827615728 0.428737449929421 no 1423 0.470780758457644 2224 4421505 YNR035C ARC35
SGTC_1086 cerivastatin 2.18 µM 0.0732021466674976 0.428780762964168 no 1424 0.470822629089763 2294 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1780 st038448 24.544 µM 0.0726573192691859 0.429005016537735 no 1425 0.471039406512543 2231 728868 YDL195W SEC31
SGTC_1756 st041558 35.5 µM 0.0720377409359349 0.429260065802476 no 1426 0.471285936467526 2291 3955792
SGTC_1693 xanthone 101.9 µM 0.069866778760857 0.430153974202098 no 1427 0.472149847599267 2210 7020 An insecticide.
SGTC_1859 st055998 20 µM 0.069204029793329 0.430426937144803 no 1428 0.472413607744574 2295 676301
SGTC_2708 st078559 56 µM 0.0688591467532162 0.430568995475324 no 1429 0.472550868731433 2279 17250902
SGTC_47 0149-0135 24.25 µM 0.0688274908332307 0.43058203509164 no 1430 0.472563467725085 2286 5239155
SGTC_3095 9117207 49.47 µM 0.0676321371296122 0.431074477047754 no 1431 0.473039236115302 2278 17015229
SGTC_1879 gemcitabine 100 µM 0.0645511985111286 0.432344203228469 no 1432 0.47426567078242 2269 60750 A nucleoside analog which inhibits DNA replication.
SGTC_672 1441-0018 53.7 µM 0.0641568318938361 0.432506781589135 no 1433 0.474422674850774 2263 251141
SGTC_2998 9066762 71.4286 µM 0.0639552934028493 0.432589870615355 no 1434 0.474502912292546 2253 4945196
SGTC_3252 9135871 49.47 µM 0.0622206598966779 0.43330513731141 no 1435 0.475193555073087 2278 17682838
SGTC_2359 9039622 200 µM 0.0620629349902128 0.433370185192053 no 1436 0.475256356832015 2259 6463596
SGTC_963 1269-2853 151 µM 0.0610765160311621 0.433777038561976 no 1437 0.475649135859605 2237 3668223
SGTC_1915 st067105 30.6 µM 0.0607983560661797 0.433891779715759 no 1438 0.475759899785179 2287 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2929 9013348 24.6 µM 0.0604199780105616 0.434047869833679 no 1439 0.475910573786035 2247 2995952
SGTC_387 norethindrone acetate 66.7 µM 0.0602038365625553 0.434137038035914 no 1440 0.475996645062321 2225 541197
SGTC_1312 1218-2183 165 µM 0.0600086636121184 0.434217558656392 no 1441 0.476074367281325 2298 6744073
SGTC_1690 st023502 41.2 µM 0.0576290207601225 0.435199523463766 no 1442 0.477022066428689 2310 24207482
SGTC_2801 7907800 81.82 µM 0.0574087283772191 0.435290447904578 no 1443 0.477109805115738 2242 6620925
SGTC_462 ag-879 158 µM 0.0572355590065223 0.435361924989522 no 1444 0.477178776292442 2303 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3091 9116372 49.47 µM 0.0571390985961211 0.435401740734898 no 1445 0.477217195554134 2237 17169793
SGTC_1008 4106-0037 6 µM 0.0566536304459976 0.435602136258864 no 1446 0.477410556096669 2301 2905394
SGTC_1996 st072960 66.8 µM 0.0566257672200663 0.435613638372051 no 1447 0.477421654099772 2317 1719405
SGTC_874 0599-0792 117 µM 0.0553449367794015 0.436142431799188 no 1448 0.477931831315484 2301 765305
SGTC_2953 9074162 66.49 µM 0.0552317501934657 0.436189166612921 no 1449 0.477976917268086 2313 16451992
SGTC_1772 st048439 82.2 µM 0.0541137658301445 0.436650830828956 no 1450 0.478422262385777 2197 2927068 YDL195W SEC31
SGTC_1389 3405-0187 19 µM 0.0539463332629809 0.436719978440523 no 1451 0.478488960890093 2241 799890
SGTC_1155 4088-0394 48.2 µM 0.0538592619822238 0.436755938583635 no 1452 0.478523646878494 2287 2326248
SGTC_3313 9133968 57.047 µM 0.0537694078730974 0.436793048573344 no 1453 0.478559441613671 2316 1494643
SGTC_3059 1327-0034 3 µM 0.0535088200423217 0.436900675195734 no 1454 0.478663251670574 2261 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1241 0364-0022 50.8 µM 0.0528557574301263 0.437170420200726 no 1455 0.47892341777228 2269 4563895
SGTC_2451 5856223 45.7 µM 0.0524321139270873 0.437345420151572 no 1456 0.479092193043548 2275 2179896
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0520035333560707 0.43752247199499 no 1457 0.479262939007219 2177 61125 An anti-inflammatory.
SGTC_2710 st078562 53.7235 µM 0.0519133070965303 0.437559747154877 no 1458 0.479298885522179 2314 17250908
SGTC_2163 5671233 125 µM 0.0517955578073713 0.437608393732966 no 1459 0.479345797579172 2311 701023
SGTC_1431 4049-0260 9.09 µM 0.0474160149649574 0.439418408220774 no 1460 0.481090832640005 2316 3854841
SGTC_2057 5236571 38.335 µM 0.0467821495776236 0.439680483339419 no 1461 0.481343428014304 2304 54684039 YBR257W POP4
SGTC_876 0720-0963 56.8 µM 0.044527373652374 0.44061294629868 no 1462 0.482242016295897 2328 765861
SGTC_2991 9074669 71.4286 µM 0.0431890243002841 0.441166577018064 no 1463 0.482775427132867 2313 17333109
SGTC_3276 9139060 49.47 µM 0.0424930906317962 0.441454507197402 no 1464 0.483052809827133 2345 4870619
SGTC_1467 k284-1082 293 µM 0.0424869543112573 0.441457046128745 no 1465 0.483055255655993 2339 3334705
SGTC_2463 5473429 200 µM 0.042101753852237 0.441616429432666 no 1466 0.483208791020167 2233 5399405
SGTC_1131 3454-3128 32.3 µM 0.0412686621582263 0.441961167726247 no 1467 0.48354085787632 2260 710982
SGTC_1522 st012842 45.6 µM 0.0407180550288592 0.442189036375011 no 1468 0.483760333850052 2330 3491067 YOR116C RPO31
SGTC_165 k038-0023 64.381 µM 0.0396483351555351 0.442631794346648 no 1469 0.484186745914915 2341 46368543
SGTC_3292 9120825 59.784 µM 0.0395400523471298 0.442676616696961 no 1470 0.484229910657456 2346 24824900
SGTC_936 3005-4620 401 µM 0.0393401313206525 0.442759373499477 no 1471 0.484309605599843 2345 777207
SGTC_1262 0737-0114 49.6 µM 0.0390582365168541 0.442876067382164 no 1472 0.484421978987033 2336 765919
SGTC_2677 mitomycin C 100 µM 0.0389260790924734 0.442930777309094 no 1473 0.484474662106621 2336 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_988 1497-1057 103 µM 0.0382062849354774 0.443228773482627 no 1474 0.484761604951199 2335 3533044
SGTC_302 1094-0063 18.9 µM 0.0379713471384459 0.443326045144483 no 1475 0.484855263608819 2321 5440289
SGTC_1594 piperine 70.1 µM 0.0376646955369864 0.443453013721752 no 1476 0.48497751244594 2340 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_515 4092-1064 102 µM 0.0371578156979038 0.44366289918584 no 1477 0.485179586781353 2341 717353
SGTC_205 1486-1330 71.903 µM 0.036822108503139 0.443801915312743 no 1478 0.485313422982046 2326 4118834
SGTC_2641 levomentholum 100 µM 0.0362315260312702 0.444046491897249 no 1479 0.485548874173839 2325 16666
SGTC_851 0394-0702 453 µM 0.0362232319436496 0.444049926860975 no 1480 0.485552180865467 2348 762646
SGTC_2054 5233173 129 µM 0.0361804651419919 0.44406763863017 no 1481 0.485569231174339 2312 6889
SGTC_1782 st039423 80.636 µM 0.0347665894038177 0.444653254589646 no 1482 0.486132931155114 2304 2068169
SGTC_3093 9117344 49.47 µM 0.0343019045643873 0.444845749757598 no 1483 0.486318203071052 2297 24824913
SGTC_2507 purpurin 79.67 µM 0.0342361916295548 0.44487297231718 no 1484 0.486344403350223 2351 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_108 0509-0257 621.132 µM 0.0334746329584647 0.445188478245426 no 1485 0.486648047229292 2335 536624
SGTC_3320 9137005 35.139 µM 0.0329865397513324 0.44539070851435 no 1486 0.486842660761669 2213 4908713
SGTC_2772 vinpocetine 57.06 µM 0.0328370023333717 0.445452668773283 no 1487 0.486902285259223 2330 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_829 1635-0120 117 µM 0.0319436919424829 0.445822836230007 no 1488 0.487258477635946 2338 285054
SGTC_332 4112-0506 40.9 µM 0.0310292834297142 0.446201795181265 no 1489 0.487623093056084 2344 2790355
SGTC_1626 st003712 1.76 µM 0.0310093216636682 0.446210068499133 no 1490 0.487631052818199 2311 24207035
SGTC_273 hydroxyurea 18.1 mM 0.0299215166253915 0.446660953543044 no 1491 0.488064822872657 2359 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_705 1124-0212 310 µM 0.0293959784580055 0.446878808955426 no 1492 0.488274390072926 2359 9554485
SGTC_2712 st079126 47.7 µM 0.0272904614972828 0.447751785356517 no 1493 0.489114032329569 2351 3152970
SGTC_827 3253-0474 693 µM 0.0272188527243934 0.447781479817284 no 1494 0.489142589488385 2354 5402065
SGTC_1926 methyl fluorone black 53.6 µM 0.0264374461121348 0.448105529602656 no 1495 0.489454213450482 2363 72721 Reacts with homocysteine.
SGTC_3306 9127676 59.7925 µM 0.0252868340763053 0.448582752080029 no 1496 0.489913087729848 2313 41905287
SGTC_1514 1189-1591 158 µM 0.0238550896347219 0.449176679546856 no 1497 0.490484098678711 2352 767698 YMR146C TIF34
SGTC_2249 haloperidol 116.36 µM 0.023703443993508 0.449239593075699 no 1498 0.490544579434626 2361 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1068 loratadine 26.9 µM 0.0236012176113935 0.449282004658418 no 1499 0.490585350454689 2317 3957 A H1 histamine antagonist.
SGTC_149 3970-0822 46.1 µM 0.0231404087448126 0.449473191782328 no 1500 0.4907691363948 2362 3114250 YBL034C STU1
SGTC_1011 4112-3381 17.4 µM 0.0220074103673405 0.449943316511217 no 1501 0.491221022176074 2296 2877139
SGTC_1245 0418-0076 17.2 µM 0.0214533703447266 0.450173234707035 no 1502 0.491441999983194 2339 6790114
SGTC_1486 3970-0793 4.53 µM 0.0212406888532143 0.450261498742801 no 1503 0.491526828292108 2370 2844330
SGTC_5 0352-0601 109.883 µM 0.0212238302681209 0.450268495257358 no 1504 0.49153355237868 2310 762456
SGTC_352 k048-0007 5.11 µM 0.0212082087843412 0.450274978373863 no 1505 0.491539783046612 2351 6811911
SGTC_521 r062-0005 13.8 µM 0.020070256695473 0.450747278692481 no 1506 0.491993663541616 2365 2832033
SGTC_1744 st037937 38.9 µM 0.0199659420367318 0.450790577377836 no 1507 0.492035270732093 2340 1016152
SGTC_1231 0242-0792 125 µM 0.0184778608055056 0.45140831018321 no 1508 0.492628819534369 2359 3707635
SGTC_244 nsc-207895 1.295 µM 0.0178520391760227 0.451668136719723 no 1509 0.492878445050996 2364 42640
SGTC_2760 etidronate 98.04 µM 0.0174836988901156 0.451821072697632 no 1510 0.493025368630637 2378 3305 A chelator and antioxidant.
SGTC_89 0302-0250 142.109 µM 0.0167261604301962 0.452135627359834 no 1511 0.493327538536645 2368 4203518 YLR208W SEC13
SGTC_2255 7941087 197.44 µM 0.016085263051664 0.452401772314839 no 1512 0.493583185188337 2387 935561
SGTC_450 aminopyrene 156 nM 0.015898176822502 0.452479467505819 no 1513 0.493657812252132 2374 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1051 3253-3903 78 µM 0.0144894250616401 0.453064567392699 no 1514 0.494219757978892 2378 5509239
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0131188290555727 0.453633917791757 no 1515 0.494766494538392 2360 6857784
SGTC_993 3909-8757 62.7 µM 0.0129141833228271 0.453718936554647 no 1516 0.494848129457573 2368 4288324 YLR208W SEC13
SGTC_134 0269-0018 6.916 µM 0.0127649484159598 0.453780936581274 no 1517 0.494907660664385 2366 4378915
SGTC_1284 0929-0043 16 µM 0.0119932316680679 0.45410156623258 no 1518 0.495215507507557 2373 1239883
SGTC_1788 fluconazole 20 µM 0.0119665613066059 0.454112647658936 no 1519 0.495226146678895 2323 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_118 0083-0097 135.343 µM 0.0103704282725488 0.454775899152874 no 1520 0.495862871851457 2389 5207356
SGTC_1416 3966-0321 25.3 µM 0.0100582248497789 0.454905645865165 no 1521 0.495987416499185 2385 582530 YLR208W SEC13
SGTC_3055 9094636 49.47 µM 0.0093642258527527 0.455194077879724 no 1522 0.496264268981104 2384 25236176
SGTC_764 1951-2361 146 µM 0.00924871600637935 0.45524208707278 no 1523 0.496310348747063 2391 5438930
SGTC_891 0929-0073 133 µM 0.00742855130036098 0.455998685392963 no 1524 0.497036464060499 2380 5603632
SGTC_899 1083-0020 478 µM 0.007322740221054 0.456042673426803 no 1525 0.497078675425582 2395 767123
SGTC_2190 6049624 200 µM 0.00515409664031224 0.456944345017071 no 1526 0.497943822036538 2381 2265554
SGTC_2265 7929201 200 µM 0.0049526273375899 0.457028122596309 no 1527 0.498024195633225 2396 1265108
SGTC_3051 9093778 49.47 µM 0.00399350426276117 0.457426983721365 no 1528 0.498406826537298 2400 17217378
SGTC_1021 4476-0760 85.3 µM 0.00327332893784621 0.45772650419668 no 1529 0.498694133021024 2397 746768
SGTC_3196 9111891 49.47 µM 0.00317982379827108 0.457765394691482 no 1530 0.498731435980444 2401 18891510
SGTC_718 1130-0073 349 µM 0.0027760968804695 0.457933316725699 no 1531 0.498892499002423 2390 6740020
SGTC_392 N-ethylmaleimide 8.33 µM 0.00227093916051813 0.458143437419958 no 1532 0.499094027131359 2396 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1670 st016595 4.04 µM 0.00108118841587109 0.458638361159569 no 1533 0.499568668311864 2400 597879
SGTC_2589 lobaric acid 100 µM 0.000810687052189821 0.458750895843521 no 1534 0.499676582694133 2403 73157 A novel microtubule depolymerizer.
SGTC_293 4049-0273 38.5 µM 0.000687882543968071 0.458801986387464 no 1535 0.499725574590903 2403 1380311
SGTC_24 0417-1663 219 µM 0.000397990435712084 0.458922593334313 no 1536 0.499841224792191 2402 4329390
SGTC_1003 4049-0218 100 µM 0 0.45908817975332 no 1537 0.5 2406 295161
SGTC_1235 benzylparaben 21.5 µM -0.00160769488364488 0.459757143257947 no 1538 0.499358622813222 2409 7180
SGTC_2280 7785178 200 µM -0.00166252784799205 0.45977996133128 no 1539 0.499336747654629 2411 2954328
SGTC_2246 7293507 91.5585 µM -0.00256597409865887 0.460155938552768 no 1540 0.49897632556498 2409 887656
SGTC_2909 7941780 10.49 µM -0.0027530006209256 0.460233775771776 no 1541 0.498901713041663 2414 1243215
SGTC_1787 fluconazole 80 µM -0.00358100095373566 0.46057839352379 no 1542 0.49857139036671 2420 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1254 0550-0035 264 µM -0.00557168028859821 0.461407044596131 no 1543 0.497777232660463 2415 15121435
SGTC_2129 girgensonine 121.053 µM -0.00609871311710113 0.461626458369269 no 1544 0.497566980563969 2419 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1001 4048-4355 44.4 µM -0.00659193015755458 0.461831804569147 no 1545 0.49737021939626 2416 21824233
SGTC_1460 k062-0059 9.15 µM -0.00686837707173977 0.461946905052461 no 1546 0.497259935531936 2382 1373085
SGTC_648 0375-0473 33.3 µM -0.00716081753725202 0.462068668024292 no 1547 0.497143271536395 2417 1713139
SGTC_872 0588-0139 234 µM -0.00896682560338656 0.462820711068416 no 1548 0.496422802082701 2422 2047100
SGTC_2737 bleomycin 30.5 nM -0.00921604420674745 0.46292449912846 no 1549 0.496323382353829 2417 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_747 3448-8087 38.7 µM -0.00956650008998839 0.463070452117316 no 1550 0.496183576850582 2434 5168703
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0117119749099802 0.46396407726205 no 1551 0.495327704838384 2419 756377
SGTC_2322 7413319 38.22 µM -0.0124961378477708 0.464290739487731 no 1552 0.495014892011448 2443 1840400
SGTC_1374 2889-5571 141 µM -0.0140320621814618 0.464930635833109 no 1553 0.494402200815157 2454 2853281
SGTC_2963 9082507 9 µM -0.0143276703842535 0.465053802495326 no 1554 0.494284282060535 2453 16459611
SGTC_268 camptothecin 39.6153 µM -0.0145655548213382 0.465152920688614 no 1555 0.494189389803699 2434 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2491 paeonol 100 µM -0.0153829947776 0.465493536005445 no 1556 0.493863315012281 2428 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2858 9025781 8.96 µM -0.0163225447084449 0.465885063982951 no 1557 0.493488535929984 2444 4894980 YPL153C RAD53
SGTC_1977 st070720 65.3 µM -0.0165833155901288 0.465993737943049 no 1558 0.49338451747987 2478 682188
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0184728091231413 0.466781242923484 no 1559 0.492630834520126 2436 140250 A respiratory chain inhibitor.
SGTC_393 acivicin 6.25 µM -0.0185717633795377 0.466822488787003 no 1560 0.492591364254653 2453 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1849 st056239 19.2 µM -0.0196049328047478 0.467253153057077 no 1561 0.492179264390674 2447 5393181
SGTC_1912 st060209 90.8 µM -0.019747970509106 0.467312779639323 no 1562 0.49212221164818 2455 688787
SGTC_429 1112-0049 25.5 µM -0.0213721544681864 0.467989886784054 no 1563 0.491474393003122 2453 2836170
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0213840434575304 0.467994843536683 no 1564 0.491469651066313 2445 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_962 1254-0300 21.5 µM -0.0216887248964101 0.468121872889816 no 1565 0.491348128943971 2441 7340576
SGTC_1785 bathophenanthroline 24 µM -0.0217408952226782 0.468143624336512 no 1566 0.49132732090146 2453 72812 An iron chelator.
SGTC_96 0929-0093 37.281 µM -0.0229657527294845 0.468654333069627 no 1567 0.490838795551304 2442 6991579
SGTC_1236 0330-0013 258 µM -0.0230277370783976 0.468680179044731 no 1568 0.490814073911691 2465 4617066
SGTC_1498 4478-3555 97.6 µM -0.0230387408087009 0.468684767348066 no 1569 0.490809685222751 2440 3437919
SGTC_1465 k213-0056 144 µM -0.0231106673576696 0.46871475917288 no 1570 0.490780998319362 2436 24048857 YMR208W ERG12
SGTC_384 k007-0144 5.16 µM -0.0234862104944082 0.468871355468039 no 1571 0.490631218941815 2476 6824886
SGTC_247 mechlorethamine 29.705 µM -0.023919974807882 0.469052235181059 no 1572 0.490458220624017 2444 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3044 9093193 49.47 µM -0.0241132953394693 0.469132851900267 no 1573 0.490381119129647 2478 25236277
SGTC_926 2268-1401 59.4 µM -0.0257650238032522 0.469821691509414 no 1574 0.489722379771736 2450 2931578
SGTC_1548 st061468 90.8 µM -0.0261097613523853 0.469965472897372 no 1575 0.489584895642314 2455 390799
SGTC_1106 tegaserod maleate 11.7 µM -0.0286058720447799 0.471006653754902 no 1576 0.488589464393916 2487 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_853 0419-0306 21 µM -0.0299324244632634 0.471560068096587 no 1577 0.488060473223203 2473 762713
SGTC_2343 7990716 14.84 µM -0.0301668506654059 0.471657872326337 no 1578 0.487966992914735 2465 6456862
SGTC_2336 9001819 198.65 µM -0.0308975887670651 0.471962752247725 no 1579 0.487675606445849 2479 2989602
SGTC_3151 9099821 49.47 µM -0.0341078910133944 0.473302352825733 no 1580 0.486395558014478 2501 17174189
SGTC_2398 5228213 48.84 µM -0.0347573348966085 0.473573391128711 no 1581 0.486136620939294 2476 80771 YMR134W ERG29
SGTC_391 gliotoxin 8.33 µM -0.0362246708042175 0.474185812578066 no 1582 0.485551607219636 2522 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2480 5767542 37.17 µM -0.0363768815828227 0.474249344252147 no 1583 0.485490923900362 2505 2867358
SGTC_173 1273-0061 2.693 µM -0.0377783344469626 0.474834331070668 no 1584 0.484932209322739 2514 2847414 YPL266W DIM1
SGTC_2159 5658611 73.75 µM -0.038557588481072 0.475159626596982 no 1585 0.484621558308798 2473 793844
SGTC_1057 3448-5381 134 µM -0.0388338023422104 0.475274934616808 no 1586 0.484511447390043 2507 5497911
SGTC_917 harmaline 728.087 nM -0.0391529335170981 0.475408161442382 no 1587 0.484384229225211 2520 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3088 9117578 49.47 µM -0.0408422448574646 0.476113439109218 no 1588 0.483710830456358 2491 678341
SGTC_479 n-linoleoylglycine 10 µM -0.0409083280999378 0.476141030014339 no 1589 0.483684489071557 2483 6433346 An anti-infammatory.
SGTC_1620 st003704 16.5 µM -0.0418796849657512 0.476546601559232 no 1590 0.48329730561818 2477 2834414
SGTC_1309 pyrazolanthrone 13.4 µM -0.0420015924389503 0.47659750342569 no 1591 0.48324871432811 2484 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3136 9095672 49.47 µM -0.0420645286797682 0.476623782293327 no 1592 0.483223628570958 2456 17217380
SGTC_735 3076-0345 636 µM -0.0422223277195101 0.476689671328667 no 1593 0.483160731741611 2498 2888990
SGTC_1358 1509-0022 2.48 µM -0.0443234618398777 0.47756706053269 no 1594 0.482323285102872 2514 3258434
SGTC_269 exalamide 29 µM -0.0448644471279892 0.477792982330489 no 1595 0.482107677688304 2503 3316 A derivative of salicylamide.
SGTC_1835 st008666 49.2 µM -0.0453483354321159 0.477995065807259 no 1596 0.481914830468675 2491 690455
SGTC_2394 5221648 200 µM -0.045995284315197 0.478265256161472 no 1597 0.481657004252407 2532 788586
SGTC_1664 st014217 9.02 µM -0.0464232003735176 0.478443975609741 no 1598 0.481486472610409 2502 3982782
SGTC_2195 6536160 144.242 µM -0.0475169877434362 0.478900816303622 no 1599 0.481050595683374 2498 3834386
SGTC_1847 st056231 15 µM -0.0479792070076905 0.47909387916677 no 1600 0.480866406961569 2488 5393180
SGTC_924 2046-0044 21.3 µM -0.0490907172440888 0.479558162260956 no 1601 0.480423500527898 2488 3623589
SGTC_3204 9114183 49.47 µM -0.0493925173764687 0.479684230421095 no 1602 0.480303245577037 2494 17027248
SGTC_2904 7225135 42.03 µM -0.0496946523028567 0.479810440467271 no 1603 0.480182859020096 2529 4446116
SGTC_3323 9138564 53.9225 µM -0.0500201228974336 0.47994640072647 no 1604 0.480053176319645 2510 43912313 YNL103W MET4
SGTC_2861 9024595 19.48 µM -0.0515629103698318 0.480590907578466 no 1605 0.47943848662123 2477 16482810
SGTC_2043 5101342 149 µM -0.0524720755004273 0.480970739533297 no 1606 0.479076272597765 2523 678451
SGTC_2635 hydroquinidine 100 µM -0.0525739924254223 0.481013319575597 no 1607 0.479035669670976 2510 442912 An experimental heart treatment.
SGTC_3182 9108849 49.47 µM -0.0526207277551964 0.481032845279546 no 1608 0.479017050744228 2550 17133045
SGTC_2333 9017922 200 µM -0.0544764278098767 0.481808180469025 no 1609 0.478277794289279 2550 3163164
SGTC_463 ikarugamyin 104 µM -0.05533681907384 0.482167686457461 no 1610 0.477935064856118 2512 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1042 0350-0096 82 µM -0.0555324127034451 0.48224941535645 no 1611 0.477857154089392 2488 3122515
SGTC_2228 7354201 200 µM -0.0558934884277645 0.48240029299115 no 1612 0.477713329102164 2527 753451
SGTC_2405 ticlatone 3.52 µM -0.0560685712747689 0.482473453306809 no 1613 0.477643590513703 2471 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_869 0564-0080 44.1 µM -0.0572921546918934 0.482984757589408 no 1614 0.477156234869323 2565 6843321
SGTC_2819 7996655 46.38 µM -0.0574091959507322 0.483033667624184 no 1615 0.477109618888031 2524 6456960
SGTC_2402 5553605 200 µM -0.057425207594069 0.483040358703602 no 1616 0.477103241687164 2550 6758546
SGTC_2069 5228469 200 µM -0.0576707330100135 0.483142961514734 no 1617 0.47700545327852 2575 2835210
SGTC_1753 st043925 64 µM -0.0584383245763453 0.483463738133786 no 1618 0.476699744160489 2505 670181
SGTC_1087 pterostilbene 9.05 µM -0.0588620866732639 0.483640832970202 no 1619 0.476530978058968 2554 5281727 Similar to reservatol, lowers cholesterol.
SGTC_79 0052-0007 94.094 µM -0.05990692374312 0.484077495577835 no 1620 0.476114882725928 2513 2801472
SGTC_2763 lisinopril 49.32 µM -0.0601181768320267 0.484165785675866 no 1621 0.476030756563981 2496 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2902 5787006 60.46 µM -0.0604568072901892 0.48430731287566 no 1622 0.475895907839591 2520 591003
SGTC_1687 st020778 55.3625 µM -0.0616720244082052 0.484815216819211 no 1623 0.475412009418062 2529 4259299
SGTC_2292 7671323 168.05 µM -0.0621811574382614 0.485028017994422 no 1624 0.475209283817592 2578 937504
SGTC_1797 st048695 56.8 µM -0.0625363047958222 0.485176460656367 no 1625 0.475067875729635 2507 592262 YIL048W NEO1
SGTC_1397 3532-0190 20.1 µM -0.0653396707009272 0.486348267535771 no 1626 0.473951778580088 2508 5322280
SGTC_2151 5563267 85.4165 µM -0.0654840478632957 0.486408620464643 no 1627 0.473894303516968 2571 5310824
SGTC_2131 toluylene red 5.2905 µM -0.0674825924265755 0.487244088798426 no 1628 0.473098759831947 2539 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1415 3966-0071 78.1 µM -0.0678713365102444 0.487406605364237 no 1629 0.472944028136594 2552 2893185
SGTC_1281 0884-0031 11.8 µM -0.0679389467951838 0.487434870423615 no 1630 0.472917117650506 2537 1548255
SGTC_2880 9042983 58.44 µM -0.0681630154045759 0.487528544677579 no 1631 0.47282793394996 2605 6464714
SGTC_1475 4092-1048 11.7 µM -0.0684264236774043 0.487638666173737 no 1632 0.472723094034066 2565 2881759
SGTC_3085 9117376 49.47 µM -0.0693272734758628 0.48801528604762 no 1633 0.47236455843278 2597 16480349
SGTC_1676 st018489 23.4 µM -0.0693724358547934 0.488034167447658 no 1634 0.472346584524231 2590 3696235
SGTC_1681 tripelennamine 100 µM -0.0694762935248128 0.488077588163163 no 1635 0.472305251037034 2512 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_605 1315-0399 119 µM -0.069868706797539 0.488241649200909 no 1636 0.472149080298993 2607 24020461
SGTC_1567 st069303 68.4 µM -0.0717195544112787 0.489015482161341 no 1637 0.471412547032641 2594 5581319
SGTC_2137 5261020 140 µM -0.0721403214961128 0.489191409292103 no 1638 0.47124511894369 2544 763655
SGTC_3193 9111931 49.47 µM -0.0723087960625783 0.489261850866641 no 1639 0.47117808238855 2558 17087244
SGTC_154 3389-1638 511.116 µM -0.0728983549505548 0.489508356312829 no 1640 0.470943501510872 2625 5238686
SGTC_1930 st074634 34.3 µM -0.0738038517464459 0.489886968997908 no 1641 0.470583231068058 2536 684253 YOR116C RPO31
SGTC_2258 7960471 200 µM -0.0738929708168576 0.489924232588163 no 1642 0.470547774517536 2597 2974708
SGTC_1329 1447-1697 50.6 µM -0.0742805071745131 0.490086275198596 no 1643 0.470393593598976 2649 2840515
SGTC_1728 st035614 33.7865 µM -0.0747388934111556 0.490277944750889 no 1644 0.470211230864431 2675 15945546
SGTC_2313 7726885 200 µM -0.0752092481048158 0.490474621125322 no 1645 0.470024113136586 2613 726423
SGTC_41 0478-0632 82.643 µM -0.0763259466706094 0.490941572024717 no 1646 0.469579891796087 2521 3750424
SGTC_3211 9128781 49.47 µM -0.077254466476414 0.491329844883931 no 1647 0.469210556543668 2671 17194361
SGTC_2013 4024628 200 µM -0.0775711274318296 0.49146226275514 no 1648 0.469084605063808 2642 5230760
SGTC_3316 9136639 10.545 µM -0.0790017494706398 0.492060516401168 no 1649 0.468515615769137 2636 4903665
SGTC_2000 st075254 36.4 µM -0.0790172075686283 0.492066980726634 no 1650 0.468509468098661 2549 17234175
SGTC_2519 cryptotanshinone 88.04 µM -0.0793956872812399 0.492225255439978 no 1651 0.468358949432792 2563 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_920 mycophenolic acid 780.421 nM -0.0807961884863311 0.492810935132867 no 1652 0.467802019654253 2577 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2237 6667747 47.222 µM -0.0810372506946056 0.492911747240949 no 1653 0.467706164069587 2613 729940 YDL015C TSC13
SGTC_317 4495-0002 170 µM -0.0811536138937958 0.492960410441409 no 1654 0.467659894265961 2580 15991618
SGTC_2671 danthron 100 µM -0.0824156257554999 0.493488191577991 no 1655 0.467158105382156 2584 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2311 7694451 200 µM -0.0834009054843989 0.493900249602335 no 1656 0.466766384274722 2611 2163142
SGTC_1128 3448-9350 235 µM -0.0835152433653857 0.493948067763508 no 1657 0.46672092864068 2667 619386
SGTC_3195 9113082 49.47 µM -0.0835354739119568 0.493956528551532 no 1658 0.466712885924233 2538 17018038
SGTC_2650 prasterone 100 µM -0.0849322886147575 0.494540708610164 no 1659 0.466157610959068 2550 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1888 azatryptophan 97.5 µM -0.0855833947861591 0.494813020274111 no 1660 0.46589879953138 2669 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_759 3486-0358 89.3 µM -0.0862724506954519 0.495101206259287 no 1661 0.465624918983007 2550 875103
SGTC_452 diindolylmethane 8 µM -0.0876063988144158 0.495659114640949 no 1662 0.465094758109285 2635 3071 Inhibits expression of several cancer promoting factors.
SGTC_1773 st048542 73.5835 µM -0.0880288995062989 0.495835822493904 no 1663 0.464926853406346 2562 3237138
SGTC_2025 5147754 141 µM -0.0881894102492784 0.495902955165144 no 1664 0.464863066959945 2625 315777 YLR208W SEC13
SGTC_1019 4262-0212 3.4 µM -0.0887128968046893 0.496121901124677 no 1665 0.464655041390941 2560 4677213
SGTC_2302 7771753 200 µM -0.0892040021095877 0.496327304831219 no 1666 0.464459892418326 2617 2203047
SGTC_1067 clotrimazole 1.36 µM -0.0915771571422067 0.497319884410038 no 1667 0.463517000565562 2584 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2399 5884133 200 µM -0.0922682802092327 0.497608952205513 no 1668 0.463242444781272 2608 722445
SGTC_1360 1598-0022 39.8 µM -0.0927688885986266 0.497818336493611 no 1669 0.463043583848578 2658 761525
SGTC_2317 5986382 200 µM -0.0935306678181124 0.498136959134679 no 1670 0.462740993538771 2614 877883
SGTC_1297 1068-0111 14.1 µM -0.094609666013085 0.498588264129992 no 1671 0.462312435955252 2565 767057
SGTC_161 4065-0411 162.148 µM -0.0948958544794599 0.4987079664963 no 1672 0.462198774653623 2665 1906281 YLR208W SEC13
SGTC_1153 4055-0057 267 µM -0.0964493010342584 0.499357719200361 no 1673 0.461581869018195 2578 882706
SGTC_678 1218-2179 85.9 µM -0.0966376234563599 0.49943648807451 no 1674 0.461507088555995 2582 6820081 YOR116C RPO31
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0971322547872904 0.49964337566034 no 1675 0.461310683171784 2612 2374 Ca(2+)-ATPase inhibitor.
SGTC_913 3487-1245 167 µM -0.0971660715494231 0.499657520074341 no 1676 0.461297255749063 2571 4016153
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.0973248762256931 0.499723942733689 no 1677 0.461234200701194 2562 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_375 3970-0961 9.27 µM -0.0976075152225616 0.499842161145555 no 1678 0.46112197836055 2637 2898222
SGTC_2866 9034245 58.44 µM -0.0983622438504884 0.499842161145555 no 1679 0.460822327147114 2704 6462273
SGTC_1884 5633444 25 µM -0.0988535016468258 0.499636684502513 no 1680 0.460627294155109 2692 5724239
SGTC_1353 1498-1206 8.11 µM -0.0988990568558107 0.499617630292084 no 1681 0.460609208878105 2576 6756808
SGTC_440 fluspirilene 35.1 µM -0.0990531856676211 0.499553163405142 no 1682 0.460548020821152 2831 3396 An atypical antipsychotic.
SGTC_485 niflumic acid 177 µM -0.100084856143109 0.499121650801256 no 1683 0.460138479003749 2704 4488 A COX2 inhibitor.
SGTC_3133 9127736 49.47 µM -0.100283752069548 0.499038459515496 no 1684 0.460059528215645 2557 27243420
SGTC_415 dibenzyl ketone 100 µM -0.100940369857087 0.498763819325466 no 1685 0.459798898118258 2688 7593
SGTC_1034 k072-0165 12.7 µM -0.101300082770075 0.498613364270758 no 1686 0.459656125246131 2598 5835461
SGTC_1117 retinoic acid 1.10837 µM -0.101566379116519 0.498501982152811 no 1687 0.45955043349106 2619 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1183 1254-0324 198 µM -0.102598874078008 0.498070128084442 no 1688 0.459140668240373 2687 5799357
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.102922711286824 0.497934679520584 no 1689 0.459012156210221 2557 6708630 An antioxidant.
SGTC_2738 aclarubicin 5.55 µM -0.103676096525378 0.497619568598056 no 1690 0.458713198309882 2668 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_464 bw-b 70c 158 µM -0.104035407488591 0.49746928369954 no 1691 0.458570624952027 2723 5353454
SGTC_2363 9053361 176 µM -0.104151571328947 0.497420697250717 no 1692 0.45852453267772 2699 6469797 YMR079W SEC14
SGTC_1191 1487-1166 10.6 µM -0.107119099501371 0.49617951999558 no 1693 0.457347247568198 2706 3955771
SGTC_730 1436-0052 41.2 µM -0.108268332666683 0.495698859169709 no 1694 0.456891420896958 2596 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1540 guanosine 70.6 µM -0.108641795045174 0.49554266177246 no 1695 0.456743304640327 2577 6802 Guanosine is a purine nucleoside
SGTC_1989 st071868 50.2 µM -0.109029604837584 0.495380464417457 no 1696 0.456589504518453 2637 16414057
SGTC_2910 7948405 25.97 µM -0.109125495803217 0.495340359149273 no 1697 0.456551476459462 2652 2971328
SGTC_425 3825-7017 13.1 µM -0.110318103425164 0.494841569107198 no 1698 0.456078550217682 2845 3397440
SGTC_2118 5526350 200 µM -0.110603855154781 0.494722058950354 no 1699 0.455965245137537 2735 743594
SGTC_2403 6032726 181.2 µM -0.111579076389661 0.494314195085261 no 1700 0.455578581514633 2659 2881040
SGTC_278 4092-0821 23.9 µM -0.112754081047995 0.493822784329008 no 1701 0.455112762056381 2685 877900
SGTC_1059 3448-6867 171 µM -0.112909484101386 0.493757792309002 no 1702 0.455051158595841 2571 3934407
SGTC_1470 k295-0292 231 µM -0.114224132714988 0.49320799222355 no 1703 0.454530060983139 2711 5045612
SGTC_2898 9056270 58.44 µM -0.114655978363619 0.493027392527083 no 1704 0.454358903955481 2592 19154699
SGTC_3078 9116413 49.47 µM -0.115293026046779 0.492760979082441 no 1705 0.454106432955483 2589 17177322
SGTC_2019 4016004 108 µM -0.116348573444466 0.492319556153963 no 1706 0.453688145468558 2680 45595336
SGTC_2099 5377090 177.372 µM -0.117099633781096 0.492005473392486 no 1707 0.453390549970401 2694 2243829
SGTC_1120 ficusin 1.78878 µM -0.11866358085366 0.491351469079323 no 1708 0.452770945446968 2762 6199 A DNA cross-linker.
SGTC_1613 st002381 52.1 µM -0.119863423622129 0.490849739924886 no 1709 0.452295669623211 2631 551167
SGTC_2718 lomofungin 53.02 µM -0.119962680443722 0.490808235089764 no 1710 0.452256355550266 2720 5351222 A RNA synthesis inhibitor.
SGTC_1478 0453-0656 35.7 µM -0.120254674094529 0.490686136772526 no 1711 0.452140704152551 2623 5258496
SGTC_105 0111-0055 734.78 µM -0.121523568327664 0.490155553840221 no 1712 0.451638174107902 2707 5179370
SGTC_661 1304-0007 33.6 µM -0.121639431296581 0.490107107067538 no 1713 0.451592291844411 2652 3117130
SGTC_333 3486-0131 40.1 µM -0.123018558860733 0.489530452088672 no 1714 0.451046200873338 2765 6744690
SGTC_1103 duloxetine 36.1 µM -0.123228836611218 0.489442530489175 no 1715 0.450962945637429 2778 60835 A selective serotonin reuptake inhibitor.
SGTC_1279 0874-0590 65.2 µM -0.123375909809512 0.489381036361768 no 1716 0.450904716251585 2692 3523074
SGTC_2285 7945142 200 µM -0.124446556496581 0.48893338612934 no 1717 0.450480856532936 2715 2970608
SGTC_348 k064-0012 10.7 µM -0.125422792642837 0.488525222213801 no 1718 0.450094422335336 2597 5066323
SGTC_2977 9011197 71.43 µM -0.125555578764968 0.488469705311862 no 1719 0.450041863804179 2850 2704722
SGTC_3041 9091929 49.47 µM -0.126227026169228 0.488188981529387 no 1720 0.449776109337358 2743 25236887
SGTC_459 nigericin 15.3 µM -0.126329427184011 0.488146169453504 no 1721 0.449735581665618 2741 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_13 0199-0087 65 µM -0.126494968334554 0.488076959878685 no 1722 0.449670065871085 2626 4589825
SGTC_235 0330-0087 5 mM -0.126787139855546 0.487954809456066 no 1723 0.449554437249694 2634 46494818 YHR062C RPP1
SGTC_2460 5552655 174.22 µM -0.126956454955561 0.487884023090307 no 1724 0.449487431749052 2743 5401989
SGTC_1561 5-methoxyflavone 52.9 µM -0.127764410769715 0.48754624247144 no 1725 0.449167707637771 2610 94525
SGTC_2666 tannic acid 100 µM -0.128110067177232 0.487401737239705 no 1726 0.449030934621924 2665 16134267 A thiamine antagonist.
SGTC_1636 st007707 68.9 µM -0.128973075650956 0.487040954893921 no 1727 0.448689476692329 2723 403051
SGTC_3353 9151644 39.2805 µM -0.129112078553905 0.48698284544801 no 1728 0.448634482351271 2734 4909158
SGTC_1437 4092-1038 11.6 µM -0.129211074439002 0.486941460897789 no 1729 0.448595316767561 2647 3977136
SGTC_1230 0170-0365 3.77 µM -0.129508343583291 0.486817190419515 no 1730 0.448477711663761 2722 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2358 9037157 4 µM -0.129817247025419 0.486688057692408 no 1731 0.448355508616183 2721 2388925
SGTC_834 0312-0008 75.7 µM -0.130163117465877 0.486543473089993 no 1732 0.44821868713849 2612 6385573 YIL048W NEO1
SGTC_604 1000-0114 314 µM -0.130812555470707 0.486271992597016 no 1733 0.447961795259326 2713 1572745
SGTC_989 1501-0895 10.3 µM -0.130866957256273 0.486249251647093 no 1734 0.447940277062913 2636 2830112
SGTC_2840 9008771 71.43 µM -0.131719025069176 0.485893077465175 no 1735 0.447603268402501 2796 2992978
SGTC_1178 0988-0033 191 µM -0.133483587433668 0.485155506133046 no 1736 0.446905471721321 2767 5392207
SGTC_1928 4'-methoxychalcone 40.3 µM -0.1336734344036 0.485076154773772 no 1737 0.44683040643777 2863 641818
SGTC_2372 9071633 200 µM -0.133868694409465 0.484994541515277 no 1738 0.446753202832971 2630 21321366
SGTC_2628 lathosterol 100 µM -0.134053989647816 0.484917093834022 no 1739 0.446679941051013 2760 6710616
SGTC_2616 abietic acid 100 µM -0.134658443694986 0.484664454699579 no 1740 0.446440965486872 2681 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_652 0437-0092 114 µM -0.135041314875564 0.48450443207578 no 1741 0.446289604472758 2649 3091274
SGTC_2418 pentamidine 31.67 µM -0.135512797530953 0.484307377344148 no 1742 0.446103223311281 2609 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2027 5150920 200 µM -0.136087878798432 0.484067029082959 no 1743 0.445875904848761 2727 786715
SGTC_100 0086-0128 49.5915 µM -0.136420205100167 0.48392813995773 no 1744 0.445744550817965 2687 93297
SGTC_1761 st044296 37 µM -0.13866575628177 0.482989708745922 no 1745 0.444857139573484 2631 1826700
SGTC_190 3970-0790 3.722 µM -0.13868621627521 0.482981158799894 no 1746 0.44484905532617 2613 2832352
SGTC_2792 7535235 81.82 µM -0.138752951122326 0.482953271292045 no 1747 0.444822686903924 2722 1281891
SGTC_1825 st052143 62.6 µM -0.138838066246754 0.482917703058569 no 1748 0.444789056379652 2772 674173
SGTC_211 3455-0679 143.504 µM -0.139099534343199 0.48280844062269 no 1749 0.444685748094857 2704 748649
SGTC_2704 st078022 71.1 µM -0.139420527995672 0.48267430538017 no 1750 0.444558925891356 2776 54697681
SGTC_2891 9063876 19.48 µM -0.139686110731516 0.482563326459739 no 1751 0.444454000418655 2699 6472478
SGTC_585 0kpi-0023 191 µM -0.141173234282968 0.481941928117042 no 1752 0.443866545117054 2759 64601
SGTC_2456 5770359 74.46 µM -0.141179017196376 0.481939511796677 no 1753 0.443864260944763 2804 3118787
SGTC_2365 9042475 200 µM -0.141189381047903 0.481935181388431 no 1754 0.443860167368768 2724 6464479
SGTC_919 tnp00227 403.569 nM -0.141357873022809 0.481864779382671 no 1755 0.44379361624247 2714 1269246 A methoxyflavone. YNL221C POP1
SGTC_2299 7976368 114.88 µM -0.14184796063618 0.48166000637799 no 1756 0.443600049971033 2757 2979718
SGTC_1109 tnp00067 928.257 nM -0.142529142105298 0.48137539679381 no 1757 0.443331031134642 2668 676295
SGTC_3176 9106582 49.47 µM -0.143876515476597 0.480812468626641 no 1758 0.442798990326772 2658 17018027
SGTC_809 3998-0021 90 µM -0.144106588957706 0.480716348475653 no 1759 0.442708150898624 2646 715485
SGTC_671 0560-0003 407 µM -0.144337651930929 0.480619816062842 no 1760 0.442616923822592 2747 3238678
SGTC_2266 7929956 200 µM -0.144523731121938 0.480542077590934 no 1761 0.442543459219894 2640 2967153
SGTC_1500 4488-1866 171 µM -0.144955856862655 0.480361550889094 no 1762 0.44237286235336 2808 2900003
SGTC_2487 5918373 44.05 µM -0.14612457428841 0.479873322770215 no 1763 0.441911523578288 2646 2876279
SGTC_1225 1216-0074 20.6 µM -0.146855433706946 0.479568023788461 no 1764 0.441623064592634 2691 4241466
SGTC_3327 9140648 26.9345 µM -0.147274056500042 0.479393159550938 no 1765 0.44145785454185 2755 8029710
SGTC_1689 st020265 53.493 µM -0.148024103623386 0.479079864959826 no 1766 0.441161872922937 2776 5758320 YPR016C TIF6
SGTC_2625 euphol 100 µM -0.14814067956106 0.479031172360666 no 1767 0.441115872980042 2765 6708538 A triterpene alcohol.
SGTC_3335 9143315 29.6265 µM -0.148457515391824 0.478898834797275 no 1768 0.440990856082657 2733 4899691
SGTC_2750 bromebric acid 70.15 µM -0.14849297976056 0.4788840220081 no 1769 0.440976862938423 2786 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2102 5377816 72.7585 µM -0.148655276923854 0.478816233956592 no 1770 0.440912826432479 2822 1379702
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.149033031510466 0.478658456327081 no 1771 0.440763784318098 2739 279621
SGTC_1300 1094-0077 113 µM -0.150267164955171 0.478143016405755 no 1772 0.440276918689985 2677 5532636
SGTC_2593 nobiletin 86.24 µM -0.150949167389426 0.477858191457664 no 1773 0.440007907422544 2762 72344 An anti-infammatory.
SGTC_1447 4239-0816 81.9 µM -0.151726958579982 0.477533376024562 no 1774 0.439701146732282 2677 1341554
SGTC_2331 7980721 200 µM -0.152050247722465 0.477398370770486 no 1775 0.43957365219875 2773 2981221
SGTC_365 0121-0052 13.6 µM -0.152147575360935 0.477357727343799 no 1776 0.439535270627464 2794 3101739
SGTC_778 3456-2434 196 µM -0.152184385738775 0.477342355616458 no 1777 0.439520754445338 2855 5539063
SGTC_3214 9129694 49.47 µM -0.153130689834096 0.476947198027372 no 1778 0.439147607148397 2758 17158655
SGTC_1510 1123-0200 71.5 µM -0.153853159739848 0.476645524339383 no 1779 0.43886275868649 2884 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2685 mycophenolic acid 18.85 µM -0.157443029300686 0.475146744473897 no 1780 0.437447851910848 2737 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2167 5876490 200 µM -0.159798235446414 0.474163629486492 no 1781 0.436520007064902 2931 686534
SGTC_3338 9144300 39.5675 µM -0.160122879759454 0.474028127992592 no 1782 0.436392139134935 2763 4901274
SGTC_1671 st016596 74.5 µM -0.162267056520807 0.473133258105185 no 1783 0.435547777960557 2725 2829167
SGTC_1922 5578187 25 µM -0.16320965969007 0.472739906309503 no 1784 0.435176680427313 2937 1350412
SGTC_1126 isoteolin 1.0172 µM -0.163611934668995 0.472572043540832 no 1785 0.435018324405958 2705 133323
SGTC_2764 methyldopa 94.69 µM -0.163926228397882 0.472440897296852 no 1786 0.4348946095588 2822 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2003 4023581 200 µM -0.16458176015476 0.472167371314847 no 1787 0.434636594355453 2811 16641307
SGTC_780 0109-0199 192 µM -0.164611857813898 0.472154813134814 no 1788 0.434624748680582 2895 610414
SGTC_1335 1486-0900 202 µM -0.164823510270051 0.472066502409874 no 1789 0.434541449302849 2677 X1335
SGTC_1166 k206-0078 225 µM -0.165760196493492 0.471675692216007 no 1790 0.434172835649592 2693 5404595
SGTC_983 1491-0821 12.2 µM -0.166513028810624 0.47136161046971 no 1791 0.433876615397244 2846 46495113
SGTC_598 3937-0236 20.2 µM -0.16658853550317 0.471330110046736 no 1792 0.433846907491996 2764 1379313
SGTC_3257 9139206 32.98 µM -0.166655986357133 0.471301970567894 no 1793 0.433820369450787 2809 4910041
SGTC_2588 indole-3-carbinol 100 µM -0.167038971315581 0.47114219774059 no 1794 0.433669692501595 2830 3712 Induces cell cycle arrest.
SGTC_838 0109-0203 71.4 µM -0.16751330218733 0.47094432386626 no 1795 0.433483090890083 2696 759422
SGTC_3140 9094243 49.47 µM -0.167938769179588 0.470766840356111 no 1796 0.433315724925591 2665 19291112
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.168432272153064 0.470560982919556 no 1797 0.433121610626452 2719 641818 YHR062C RPP1
SGTC_2121 5257820 149.641 µM -0.168766549260875 0.470421548653917 no 1798 0.432990135340461 2823 791256
SGTC_231 b-estradiol 524 µM -0.169933787198613 0.469934696826237 no 1799 0.432531104603994 2717 450 A steroid.
SGTC_845 0330-0138 4.51 µM -0.169953814710668 0.469926343794522 no 1800 0.432523229330212 2789 9039800
SGTC_2946 9065502 71.43 µM -0.17042443198655 0.469730063569102 no 1801 0.432338179623313 2687 16489101
SGTC_3207 9114163 49.47 µM -0.171048936932978 0.469469612816904 no 1802 0.432092643226166 2946 849233
SGTC_1140 3229-1848 2.98 µM -0.171778612107859 0.469165317214399 no 1803 0.431805790316813 2812 2849525
SGTC_101 0490-5701 117.494 µM -0.171806553386234 0.469153665251984 no 1804 0.431794806640181 2689 4661669
SGTC_682 0kpi-0099 17 µM -0.172652901785668 0.468800736924811 no 1805 0.431462133318401 2807 1714895 YML126C ERG13
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.173140463858452 0.468597434050312 no 1806 0.431270509832299 2767 4330530
SGTC_855 0428-0020 25 µM -0.173539374897459 0.468431102834215 no 1807 0.431113740339354 2726 6812414
SGTC_3331 9141060 1.957 µM -0.173609406659428 0.468401902735714 no 1808 0.431086219422909 2724 4906567 YPR165W RHO1
SGTC_884 0851-0618 334 µM -0.174085626552767 0.468203344951061 no 1809 0.430899084534264 2861 9642473
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.174581861533203 0.467996450380189 no 1810 0.430704101042938 2706 688803
SGTC_1047 2043-3044 82 µM -0.1747741278823 0.46791629135491 no 1811 0.430628559185184 2715 669592
SGTC_1474 0330-0125 5.35 µM -0.175250656177547 0.467717624430859 no 1812 0.430441341151779 2755 X1474
SGTC_1562 morin hydrate 59.1 µM -0.175555328933223 0.467590609113346 no 1813 0.430321649768196 2893 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1661 st013063 9.66 µM -0.175572478557026 0.467583459688193 no 1814 0.430314912689775 2724 721395
SGTC_2565 isoliquiritigenin 100 µM -0.175671450026781 0.46754220014697 no 1815 0.430276033017378 2870 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2797 7859098 81.82 µM -0.176831391529279 0.467058666152592 no 1816 0.429820415361084 2754 972681
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.17799230647335 0.466574775038336 no 1817 0.429364508904948 2860 5393153
SGTC_396 dithiazanine 1.25 µM -0.178380232968177 0.466413090979029 no 1818 0.429212186073037 2750 10578 An antihelmenthic.
SGTC_1558 st069300 45.6 µM -0.179094101346665 0.466115571958907 no 1819 0.428931906785854 2759 24208000
SGTC_2443 5493264 126.67 µM -0.179192985789924 0.466074361365566 no 1820 0.428893085558632 2879 5340055
SGTC_1605 st000082 49.1 µM -0.179724536547674 0.465852841135179 no 1821 0.428684414855943 2847 1114022
SGTC_830 4076-0286 57.8 µM -0.181132460688053 0.465266149450717 no 1822 0.428131803024353 2748 6866659
SGTC_2592 piperlongumine 83.33 µM -0.182093528631708 0.464865709097165 no 1823 0.427754663618034 2805 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3149 9097855 49.47 µM -0.182477300779687 0.464705815799411 no 1824 0.427604083319573 2874 25236625 YMR079W SEC14
SGTC_1317 1273-0028 910 nM -0.182640022253388 0.464638021892332 no 1825 0.427540239637874 2760 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1972 st070201 17.4 µM -0.18316498905353 0.464419314371323 no 1826 0.427334282142333 2838 2829099
SGTC_496 calpeptin 138 µM -0.183682952821019 0.464203534934033 no 1827 0.427131091518453 2801 73364 A calpain inhibitor.
SGTC_2612 dictamnine 15.46 µM -0.183941975326818 0.464095632237546 no 1828 0.427029487518293 2841 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1631 benzylvanillin 81.9 µM -0.185078306072383 0.463622294829098 no 1829 0.426583808445631 2875 75506
SGTC_1621 st003705 32.4 µM -0.185537443202291 0.463431056295688 no 1830 0.426403757313576 2908 24207032
SGTC_3283 9109332 35.8195 µM -0.185619427513759 0.463396909303848 no 1831 0.426371608688171 2699 17027281
SGTC_2907 7721985 69.9 µM -0.186267089305204 0.463127163511811 no 1832 0.426117657357897 2787 3267881
SGTC_2779 methotrexate 400 µM -0.18660683502122 0.462985668995751 no 1833 0.425984453657903 2758 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2757 clomiphene 4.22 µM -0.187370167911456 0.462667779466404 no 1834 0.425685205460432 2914 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3186 9110464 49.47 µM -0.187534868105063 0.462599193288537 no 1835 0.425620643908961 2863 17018021
SGTC_1672 st016598 6.51 µM -0.187726947823087 0.462519206847352 no 1836 0.425545352256587 2790 4665860 YNL267W PIK1
SGTC_807 1315-0151 48 µM -0.188024110098307 0.462395464583941 no 1837 0.425428875559633 2916 4011080
SGTC_3256 9138902 49.47 µM -0.188301248165915 0.462280063942354 no 1838 0.425320253481146 2707 17228773
SGTC_3348 9149464 3.537 µM -0.188557334031094 0.46217343228668 no 1839 0.425219887685902 2709 1951442
SGTC_1649 st011737 51.3 µM -0.188726880663709 0.462102836218417 no 1840 0.42515344122322 2780 1761035
SGTC_2350 9023895 38.85 µM -0.193255539370685 0.46021763569573 no 1841 0.423379422165263 2888 2997209
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.193472589296358 0.460127303762422 no 1842 0.423294435528164 2719 1241132 A phosphatase inhibitor.
SGTC_2928 9011484 9.79 µM -0.194210005286782 0.459820421052402 no 1843 0.423005724469447 2868 2994751
SGTC_336 4111-0029 111 µM -0.195975521051607 0.459085782395265 no 1844 0.422314662919554 2801 3131175
SGTC_2640 pentamidine 10.38 µM -0.197314663538652 0.458528652510723 no 1845 0.42179065253506 2856 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_406 estrone 100 µM -0.197721281556357 0.458359501334262 no 1846 0.421631569070514 2936 5870 A steroid.
SGTC_201 4262-0159 12.803 µM -0.198071733641117 0.458213720969695 no 1847 0.421494469981789 2858 1341029
SGTC_1375 2910-0797 186 µM -0.19924167065123 0.457727093699424 no 1848 0.421036852172507 2831 742508
SGTC_2733 amorolfine 100 µM -0.200295540084624 0.457288798166888 no 1849 0.420624725187164 2785 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3181 9108277 49.47 µM -0.200823111543292 0.45706940506224 no 1850 0.420418445334089 2774 17097298
SGTC_806 3966-4455 5.86 µM -0.201029912173657 0.456983409600654 no 1851 0.420337592476937 2765 714982
SGTC_1827 berberine 7.24 µM -0.202313815419454 0.456449559686137 no 1852 0.419835700074847 2767 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.202432310156968 0.456400293249651 no 1853 0.419789385690569 2786 689007
SGTC_2551 apiole 73.87 µM -0.202643482638704 0.456312495943765 no 1854 0.419706850404337 2754 10659 A possible DNA adduct former.
SGTC_848 0368-0089 85.6 µM -0.202674098610405 0.456299767190249 no 1855 0.419694884659175 2875 762535
SGTC_114 0364-0001 490.298 µM -0.202878003330964 0.456214993859779 no 1856 0.419615193772782 2816 4003655
SGTC_818 4072-2707 53.5 µM -0.202938520279009 0.456189834338938 no 1857 0.419591542923043 2734 882871
SGTC_3163 9099914 49.47 µM -0.203062025741337 0.456138488305097 no 1858 0.419543276203092 2851 16268368
SGTC_1212 0520-0165 585 µM -0.203324281908697 0.456029460625949 no 1859 0.419440788840492 3176 5403258
SGTC_2166 5933061 31.504 µM -0.203480808216357 0.455964389567396 no 1860 0.419379622364345 3281 2877375
SGTC_1856 st057054 55.7 µM -0.204732674979761 0.455444006624374 no 1861 0.418890495080275 3016 1266018
SGTC_2743 auranofin 4.32 µM -0.205337825787299 0.455192481519164 no 1862 0.418654096466681 2800 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2564 betulinic acid 100 µM -0.205636872816408 0.455068192126225 no 1863 0.418537286337757 3037 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1188 1403-0014 4.57 µM -0.206474173417253 0.454720218179045 no 1864 0.418210268360296 2808 9614867
SGTC_2844 9010103 25.97 µM -0.20691852478174 0.454535564189402 no 1865 0.418036744453803 2961 2480525
SGTC_1811 st050069 61.5 µM -0.207701905003804 0.454210047826809 no 1866 0.417730865069789 2764 3877702
SGTC_2344 7990960 76.95 µM -0.208496330339985 0.453879973318113 no 1867 0.417420723823794 2815 140813
SGTC_770 0389-1121 67.2 µM -0.209635307472613 0.453406797162895 no 1868 0.416976160260919 2945 6753108
SGTC_502 l-744,832 89.3 µM -0.210384969940661 0.453095393769845 no 1869 0.416683611201283 2914 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1454 4239-0054 42.6 µM -0.21047534052422 0.453057856544704 no 1870 0.416648348003912 2967 1340767
SGTC_2669 eugenol 100 µM -0.211850631519289 0.452486653946174 no 1871 0.416111783326772 2833 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_71 0417-1750 47.813 µM -0.211865104740857 0.452480643272319 no 1872 0.416106137482529 2995 6811472
SGTC_565 1418-0001 44.5 µM -0.215044157006941 0.451160661263943 no 1873 0.414866445747409 2960 2862145
SGTC_1569 carminic acid 40.6 µM -0.215153916576068 0.45111509728487 no 1874 0.414823659364018 2898 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_865 0488-0499 301 µM -0.21541096566853 0.451008392213134 no 1875 0.414723460656721 2772 9634651
SGTC_2325 6158266 200 µM -0.217096752767401 0.450308683893603 no 1876 0.41406647226953 2873 3623240
SGTC_1555 citronellol 128 µM -0.217467093811381 0.450154989539403 no 1877 0.413922174347427 2851 8842 A terpine precursor.
SGTC_2603 homopterocarpin 100 µM -0.21816975820725 0.449863399028857 no 1878 0.413648423492773 2912 101795 A weak amylase inhibitor.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.219951608611134 0.449124091393943 no 1879 0.412954421240804 2925 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2692 st077426 47.7 µM -0.220313372306223 0.448974013485934 no 1880 0.412813553206162 2944 25238571
SGTC_2483 5729050 27.16 µM -0.220459896442177 0.448913229927319 no 1881 0.412756501014216 2929 2865180
SGTC_424 splitomicin 100 mM -0.220526194398083 0.448885727509748 no 1882 0.412730687144307 2871 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1975 st070967 30.8 µM -0.22132901871778 0.44855271098771 no 1883 0.412418128270493 2910 261391
SGTC_1746 st038117 42 µM -0.222031926976297 0.448261170022177 no 1884 0.412144514719086 2904 2898218
SGTC_331 k048-0133 24.5 µM -0.222269058678624 0.448162822649639 no 1885 0.412052218632972 2788 6813582
SGTC_1768 st044301 37.178 µM -0.22381921879868 0.447519992118674 no 1886 0.411448987435334 2843 3931349
SGTC_2504 purpurogallin 52.29 µM -0.225885268252833 0.446663443765238 no 1887 0.410645327978126 2790 5281571 An antioxidant.
SGTC_555 4296-0685 37 µM -0.226022349904772 0.446606620841177 no 1888 0.410592018686017 2824 2908540 YHR072W ERG7
SGTC_519 k048-0011 62.8 µM -0.226314213812341 0.446485641413088 no 1889 0.410478522067779 2929 6836379
SGTC_1698 5-fluorocytosine 1.055 µM -0.226483689350145 0.446415395020224 no 1890 0.410412621845156 2916 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.227776186389884 0.445879719755162 no 1891 0.409910120301197 2805 688664
SGTC_2960 9079389 5.97 µM -0.227791813947127 0.445873243518056 no 1892 0.409904045467966 2970 16457355
SGTC_2762 leflunomide 42.06 µM -0.22805487715623 0.445764229307132 no 1893 0.409801789283135 2803 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2428 5615643 7.78 µM -0.229445596752851 0.445187979114289 no 1894 0.409261300090071 2940 2253075
SGTC_737 1950-0117 57.9 µM -0.230245707163079 0.444856502581674 no 1895 0.4089504232999 2915 5393513
SGTC_1839 st053978 48 µM -0.230566899036473 0.444723447318601 no 1896 0.408825642747775 2866 3788398
SGTC_2887 9044784 58.44 µM -0.23119291387487 0.444464135603103 no 1897 0.40858246740458 2818 6465546
SGTC_39 0986-0283 58.349 µM -0.231299415708815 0.444420022121393 no 1898 0.408541100288107 2980 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3103 9120822 49.47 µM -0.231453827211868 0.444356065487708 no 1899 0.408481126054397 3047 17141819
SGTC_2172 5754775 163.918 µM -0.231776656776264 0.444222355442341 no 1900 0.408355744293268 2820 2263357
SGTC_772 k072-0172 35.3 µM -0.232257699109558 0.444023128370672 no 1901 0.408168932669522 2840 5861980
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.233457710806685 0.443526196833052 no 1902 0.407703002096543 2791 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1941 st076221 61.8 µM -0.234358701324689 0.443153149953228 no 1903 0.407353258731049 2980 2828568
SGTC_2278 7948257 134.34 µM -0.234990751973548 0.442891485214181 no 1904 0.407107955562323 2980 1247028
SGTC_2260 7964312 200 µM -0.235897581807086 0.442516107260867 no 1905 0.406756072372138 2991 231951
SGTC_2281 7943571 200 µM -0.239256205605114 0.441126272779758 no 1906 0.405453461075785 3011 1244024
SGTC_167 3672-0051 66.205 µM -0.239546227944494 0.441006292181177 no 1907 0.405341027462363 2789 3237971
SGTC_3314 9135860 59.4275 µM -0.239957480132696 0.440836168766139 no 1908 0.405181609793334 2957 25252478
SGTC_3168 9103419 49.47 µM -0.239989911927792 0.440822753112551 no 1909 0.40516903861134 2842 16649256
SGTC_3083 9117465 49.47 µM -0.240117894219143 0.440769812947506 no 1910 0.405119431190637 2930 16420915
SGTC_1370 2001-0092 44.6 µM -0.240451633589084 0.440631765881969 no 1911 0.404990077112329 3031 790957
SGTC_2170 morpholine 200 µM -0.240852937328459 0.44046578122533 no 1912 0.404834549498833 2956 121171 Reacts with secondary amines.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.242111981927814 0.439945091366784 no 1913 0.404346697063609 2819 91467 include heat shock
SGTC_2001 4023502 57.655 µM -0.242351622604406 0.439845997424948 no 1914 0.404253858328016 2961 108941 YCR052W RSC6
SGTC_694 1315-0438 43.2 µM -0.24256511706025 0.43975771839444 no 1915 0.404171153390942 2871 6793154
SGTC_337 1315-0038 354 µM -0.242680791627293 0.439709888714028 no 1916 0.40412634437763 2849 1626437
SGTC_2630 antimycin a 100 µM -0.243031053579947 0.439565066074152 no 1917 0.403990670605054 2775 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2179 6298986 200 µM -0.243545287563044 0.439352460656373 no 1918 0.40379150328587 2979 738374
SGTC_3117 9124945 49.47 µM -0.244965538326558 0.438765361800187 no 1919 0.403241557466348 2796 17592065
SGTC_728 3030-5151 22.5 µM -0.245166132501509 0.43868245162897 no 1920 0.403163899303292 2833 3125388
SGTC_3230 9131665 49.47 µM -0.246709730201925 0.438044537594894 no 1921 0.402566437842839 2835 15943720
SGTC_2964 9083345 53.42 µM -0.246713619937692 0.438042930308059 no 1922 0.402564932577225 2895 17741579
SGTC_1887 st057648 70.8 µM -0.24686338010083 0.437981048337471 no 1923 0.402506978884746 2986 688672
SGTC_738 1315-0003 72.4 µM -0.247101914705376 0.43788248726491 no 1924 0.402414675977136 3003 6251474
SGTC_1770 st043884 66.3 µM -0.249142314168091 0.437039564485688 no 1925 0.401625349599724 2834 670149
SGTC_1040 k898-0338 155 µM -0.249351228978727 0.436953274382297 no 1926 0.40154455371337 3078 20969351
SGTC_556 4058-0063 51.5 µM -0.250245750482613 0.43658383548618 no 1927 0.401198653360678 2891 6615692
SGTC_294 k038-0071 157 µM -0.250730318389589 0.436383731194326 no 1928 0.401011309283641 2890 24152826
SGTC_3280 9140961 49.47 µM -0.251797197744728 0.435943216468031 no 1929 0.400598911713557 2820 4901226
SGTC_3124 9127567 49.47 µM -0.252212889896325 0.435771598565351 no 1930 0.400438257686084 3075 17592030
SGTC_2196 6573537 42.6665 µM -0.252985675544428 0.435452587293952 no 1931 0.400139641241428 2952 2903087
SGTC_12 0849-0099 9.267 µM -0.253306820928117 0.43532002859594 no 1932 0.400015562809579 2887 6071388
SGTC_2720 fluspirilene 36.88 µM -0.253696407808172 0.43515922916209 no 1933 0.399865054721759 2945 3396 An atypical antipsychotic.
SGTC_1078 idebenone 36.1 µM -0.253785968124055 0.435122265242923 no 1934 0.399830457219513 2924 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2415 st077333 57.7 µM -0.253904452587256 0.435073364431776 no 1935 0.399784687413764 3102 2766255
SGTC_2693 st077581 40.7 µM -0.254907144050927 0.43465957426088 no 1936 0.399397409174325 2960 25238761
SGTC_761 k216-0224 480 µM -0.255107634651649 0.434576844479 no 1937 0.399319983808761 3046 1340404
SGTC_357 1325-0123 420 µM -0.256834134246701 0.43386454628946 no 1938 0.398653409192207 2993 1098503
SGTC_631 k072-0230 41.5 µM -0.257434154861739 0.433617047245551 no 1939 0.398421819675121 2967 5773147
SGTC_2465 5809242 33.21 µM -0.258660555518982 0.433111257377482 no 1940 0.39794857806912 2839 2731748
SGTC_592 k241-0073 46.5 µM -0.259359339493779 0.432823115134407 no 1941 0.397678999464304 2986 4230158
SGTC_938 3126-1755 342 µM -0.261598164809258 0.4319001810313 no 1942 0.3968156295158 3032 1777771
SGTC_941 3237-0776 460 µM -0.26168174751187 0.431865732033491 no 1943 0.396783406843118 3055 760008
SGTC_3337 9144342 33.5465 µM -0.261947691106617 0.431756125597885 no 1944 0.396680885374468 2953 17682949
SGTC_3279 9140807 49.47 µM -0.262525624864829 0.431517953141568 no 1945 0.396458116080804 2832 45595718
SGTC_102 gallobenzophenone 83.616 µM -0.263231647522137 0.431227027721015 no 1946 0.396186019742573 3050 70837
SGTC_2127 5253358 187.912 µM -0.264102478661227 0.430868242318068 no 1947 0.395850476994198 2809 20612
SGTC_1116 jasmonic acid 1.58368 µM -0.264121218678727 0.430860521992857 no 1948 0.395843257065024 3027 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_308 4092-1169 104 µM -0.264674518386166 0.430632591024989 no 1949 0.395630104503707 2885 2268590 YDL196W YDL196W
SGTC_1463 k081-0032 34.1 µM -0.264751124564179 0.430601035046553 no 1950 0.395600595283791 2946 977755
SGTC_1824 st053723 68.6 µM -0.266995733684176 0.429676622603148 no 1951 0.394736222960939 2927 675225
SGTC_1356 1502-0781 85.8 µM -0.268898203616305 0.428893417203692 no 1952 0.394004009691646 2881 567702
SGTC_1401 3807-4679 7.6 µM -0.269731310147532 0.428550533345039 no 1953 0.393683485503529 2871 3291456
SGTC_1453 4237-0541 195 µM -0.270906585743108 0.4280669138127 no 1954 0.393231439842304 3010 739892
SGTC_2217 6934799 96.0675 µM -0.27110955064232 0.427983405776557 no 1955 0.393153388110703 2966 675606
SGTC_220 paclitaxel 373.376 µM -0.271241414903517 0.427929153170523 no 1956 0.393102680984139 2992 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2697 mebhydrolin 72.4 µM -0.271272181446019 0.427916495159549 no 1957 0.393090850268631 3035 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1084 voriconazole 435 nM -0.271449495235839 0.427843545935385 no 1958 0.393022669393644 2994 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_511 blebbistatin 171 µM -0.271582472855759 0.427788838812645 no 1959 0.3929715388601 3023 3476986 A myosin inhibitor.
SGTC_330 1488-0319 80.1 µM -0.272112772232877 0.427570686947284 no 1960 0.392767654575498 2942 6846614
SGTC_3022 9087993 49.47 µM -0.272877018036725 0.427256334354006 no 1961 0.392473876634115 2943 17173644
SGTC_3297 9117502 71.43 µM -0.27315644278196 0.427141411786658 no 1962 0.392366480369134 2940 7453720
SGTC_1708 st033234 31.827 µM -0.274364823266737 0.426644497090503 no 1963 0.391902136549619 3017 674664
SGTC_2788 5282734 71.43 µM -0.275989415392766 0.425976609892454 no 1964 0.39127809796203 3048 743706
SGTC_1810 st050138 53 µM -0.27656191214955 0.425741300838871 no 1965 0.391058256995973 3004 3444541
SGTC_2711 st079103 59.1 µM -0.276623401583068 0.425716028868705 no 1966 0.391034646884676 2950 54693780
SGTC_1351 1496-0003 46.5 µM -0.27724398031719 0.425460989993709 no 1967 0.3907963856248 3025 3891978
SGTC_1173 0443-0020 122 µM -0.277247918348617 0.425459371682728 no 1968 0.390794873811534 2896 5331295
SGTC_2646 retinol 96.75 µM -0.277914544658653 0.425185443620193 no 1969 0.390538979269671 2966 445354 A vitamin A analog and teratogen.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.278640734779608 0.424887080880146 no 1970 0.390260274212673 3052 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2682 pyrogallin 40.03 µM -0.279048509364052 0.424719561315928 no 1971 0.390103798809188 2926 822798 An ATP competetive kinase inhibitor.
SGTC_3001 9076041 71.4286 µM -0.279917967287982 0.424362421143646 no 1972 0.389770221070063 2894 16004211
SGTC_2202 7226349 200 µM -0.280112674854922 0.424282451196726 no 1973 0.389695530342789 2878 844334
SGTC_1862 st057513 3.81 µM -0.280393226315952 0.424167229080192 no 1974 0.389587916662967 2905 5393163
SGTC_944 3370-0224 231 µM -0.282817233060879 0.42317196363661 no 1975 0.388658471677258 2941 4580514
SGTC_2576 guaiol 23.12 µM -0.282885991228762 0.423143739550808 no 1976 0.388632116770182 3019 227829
SGTC_732 3970-1727 52.7 µM -0.283575283517206 0.422860818336066 no 1977 0.388367940372271 3012 1275699
SGTC_2373 9071805 200 µM -0.284179661387413 0.422612783118897 no 1978 0.388136350536354 3047 10149009
SGTC_3299 9121982 43.1275 µM -0.284182794109209 0.422611497537285 no 1979 0.388135150221151 2931 17594604 YPL160W CDC60
SGTC_1332 1480-0653 17.5 µM -0.284221359413937 0.422595671479857 no 1980 0.388120373854042 3040 5749438
SGTC_2144 5628481 200 µM -0.285396128545193 0.422113641055225 no 1981 0.387670336617655 2916 2818399
SGTC_2889 9059656 51.95 µM -0.285945352833404 0.421888323711169 no 1982 0.38745998837264 2997 3949838
SGTC_2296 7971656 126.45 µM -0.286111977042715 0.421819971763328 no 1983 0.38739617924157 2986 666570
SGTC_178 4092-0806 87.505 µM -0.287217583211615 0.42136649397095 no 1984 0.386972861904066 2989 2169044
SGTC_861 0443-0273 110 µM -0.287614339790519 0.421203784837697 no 1985 0.386820983468542 3001 6149169
SGTC_562 3772-2733 112 µM -0.288386951186122 0.420886976983332 no 1986 0.386525277545306 3031 2876874 YIL048W NEO1
SGTC_1832 st054113 55 µM -0.289076946536461 0.420604088978761 no 1987 0.386261247411881 3029 1251267
SGTC_569 4130-2812 160 µM -0.289290650080917 0.420516481958832 no 1988 0.38617948336856 2916 743552
SGTC_617 3770-0098 35 µM -0.290616942489279 0.41997286122882 no 1989 0.385672150434254 2928 5962639
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.291382097766075 0.419659308755402 no 1990 0.385379552369809 2927 5106787 A p450 inhibitor.
SGTC_2755 lomerizine 42.69 µM -0.291688309072387 0.419533840905076 no 1991 0.385262474357679 2952 3949 A calcium channel blocker.
SGTC_3135 9127742 49.47 µM -0.292567726669787 0.419173551480405 no 1992 0.384926292614804 2976 3643468
SGTC_2408 sulbentine 18.36 µM -0.293900766270285 0.418627546535158 no 1993 0.384416866276889 2964 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1100 amiodarone 5.07 µM -0.294163427050244 0.418519980721177 no 1994 0.384316512931003 3029 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_152 4469-0003 551.229 µM -0.29460353764059 0.418339758665385 no 1995 0.384148379704654 2901 697280
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.294850131071491 0.418238787956405 no 1996 0.384054184388054 2948 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_123 0083-0120 66.675 µM -0.296234778098982 0.417671927474657 no 1997 0.383525395510471 2942 16001701
SGTC_781 4335-2806 94.4 µM -0.297629667418259 0.417101046828104 no 1998 0.382992914428305 3083 845254
SGTC_1506 4226-2149 212 µM -0.298053705013505 0.416927537273765 no 1999 0.382831087285753 3028 991114
SGTC_1663 st014140 55.4 µM -0.298987572785657 0.416545470282725 no 2000 0.38247476379348 2959 4207120
SGTC_2514 salinomycin 42.74 µM -0.299329319324095 0.416405673520741 no 2001 0.382344392964404 3112 23682228 A polyether potassium ionophore.
SGTC_2007 4011539 71.82 µM -0.299346852525478 0.416398501575725 no 2002 0.382337704688508 2912 45595301
SGTC_1118 chelidonine 707.474 nM -0.299952215736585 0.416150895220484 no 2003 0.382106802277504 3066 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_78 0336-0123 156.75 µM -0.300257847368748 0.416025898054231 no 2004 0.38199024177085 2854 6765896
SGTC_1987 st072290 61.9 µM -0.300432733020798 0.415954377173752 no 2005 0.381923549426935 2989 54697379
SGTC_1916 st067606 49.2 µM -0.301270414130782 0.41561183944735 no 2006 0.381604149790792 3012 19590279
SGTC_2851 9015922 71.43 µM -0.303213069285381 0.414817711917545 no 2007 0.38086374485918 3122 2996893
SGTC_1256 0570-0116 285 µM -0.303386034875652 0.414747023068955 no 2008 0.380797843515494 2970 410638
SGTC_2942 9052777 62.25 µM -0.303562874049654 0.414674753989662 no 2009 0.380730469879002 2977 6469503
SGTC_1180 1193-0155 285 µM -0.303654493243461 0.414637312998375 no 2010 0.380695565470506 3074 2921347
SGTC_417 st075190 100 µM -0.304622393249351 0.414241819563869 no 2011 0.380326881393562 3079 222757
SGTC_1755 st041960 45.185 µM -0.305850704629447 0.413740044710622 no 2012 0.379859160200159 3075 2257073
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.306081720173975 0.413645688752528 no 2013 0.379771212809367 3015 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1382 3002-2117 298 µM -0.307280728417565 0.413156046198889 no 2014 0.37931485153862 3105 1497314
SGTC_1385 3091-4834 14.1 µM -0.307591094443268 0.413029323077692 no 2015 0.379196748745618 3047 4072814
SGTC_3020 9089140 49.47 µM -0.30883898350088 0.412519898861724 no 2016 0.378722006601673 3036 17217859
SGTC_1209 2323-2347 50.3 µM -0.309037136766345 0.41243902053016 no 2017 0.378646638743339 3044 5412760
SGTC_2276 7947513 42.08 µM -0.309721681782275 0.41215964493769 no 2018 0.378386306663304 3022 2105100
SGTC_2207 7258803 200 µM -0.310573735246414 0.411811968215157 no 2019 0.378062348327248 3030 3666799
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.310678555623527 0.411769201490813 no 2020 0.378022500600582 2968 4174840
SGTC_1946 st076057 65.1 µM -0.311385518376725 0.411480788013076 no 2021 0.377753780863851 2927 953009
SGTC_2376 9072922 81.32 µM -0.311708217954389 0.411349154946799 no 2022 0.377631140950548 3071 17087968
SGTC_1414 3917-0015 5.4 µM -0.3117466091955 0.411333495358487 no 2023 0.377616551425422 3064 6618702
SGTC_1469 k284-2957 126 µM -0.312338388951761 0.411092129348127 no 2024 0.377391684063608 2983 23884841
SGTC_3066 9117245 49.47 µM -0.312597245537532 0.410986561486273 no 2025 0.377293335535259 3000 17176980
SGTC_940 3232-1287 54.8 µM -0.313646043818708 0.410558902693158 no 2026 0.376894942462912 2987 1585493 YIL048W NEO1
SGTC_534 k292-0788 63.4 µM -0.314225874856222 0.41032251594786 no 2027 0.376674745967793 3120 4146317
SGTC_2492 derrusnin 100 µM -0.314231114288966 0.410320380073216 no 2028 0.376672756424859 2888 1715307 Part of coumarin class of compounds.
SGTC_1321 1326-2144 215 µM -0.3150697344814 0.409978547697798 no 2029 0.37635435373283 3069 3513030
SGTC_3173 9105693 49.47 µM -0.315508917387692 0.409799558370999 no 2030 0.376187640736456 3113 17096658
SGTC_2895 9054447 58.44 µM -0.315890894384831 0.409643898636871 no 2031 0.376042661775373 2973 2697450
SGTC_992 3909-8734 162 µM -0.318447482774146 0.408602429170707 no 2032 0.375072762658341 3008 4288319
SGTC_2221 6807166 181.081 µM -0.32112039190377 0.407514264341967 no 2033 0.374059578749811 3040 674925
SGTC_1303 1160-0052 261 µM -0.323953079088242 0.406361831023612 no 2034 0.372986778816687 3003 3562476
SGTC_1186 1319-0216 26 µM -0.32428740756543 0.406225868142346 no 2035 0.372860226161148 3129 4565136
SGTC_2795 7780010 54.55 µM -0.324715349738623 0.406051851455439 no 2036 0.372698258132021 3113 953673
SGTC_2761 levamisole 97.89 µM -0.325352695129301 0.405792718297548 no 2037 0.372457076667015 3132 26879 An alkaline phosphatase inhibitor.
SGTC_2820 7989630 71.43 µM -0.326481539519361 0.405333851857553 no 2038 0.372030027069283 3055 2984098
SGTC_1765 st044815 90.4 µM -0.326892793720928 0.405166712528837 no 2039 0.37187448585709 3059 645695
SGTC_3229 9132204 49.47 µM -0.327046003051161 0.405104450582978 no 2040 0.371816545617357 2981 17682924
SGTC_2021 4019055 173 µM -0.327137967697628 0.405067078700256 no 2041 0.371781768100569 3137 44827708 YER133W GLC7
SGTC_1246 0422-0085 105 µM -0.327910684374734 0.404753102293315 no 2042 0.371489597520471 3125 264295
SGTC_2485 5633444 17.78 µM -0.328145248759701 0.404657804342389 no 2043 0.371400921420573 3068 5724239
SGTC_2655 perillic acid 100 µM -0.328495071033371 0.404515690350441 no 2044 0.371268685231538 2996 5702197 An apoptosis inducer.
SGTC_59 0330-0160 1.33 µM -0.328780048284472 0.404399928716154 no 2045 0.371160972316113 3026 4293482
SGTC_1863 st057641 20.1 µM -0.331165092524337 0.40343142037256 no 2046 0.370259893023069 3027 3921635
SGTC_2956 9076196 2.52 µM -0.331185865817646 0.403422987436217 no 2047 0.370252047907999 3117 16423868
SGTC_1885 st057546 99.9 µM -0.332266960216468 0.402984178300526 no 2048 0.369843842966374 3154 702008
SGTC_362 0310-0100 9.03 µM -0.332734813143688 0.402794317700368 no 2049 0.369667234182222 3114 790235
SGTC_1124 fisetin 1.16336 µM -0.333866322733083 0.402335231713548 no 2050 0.369240216797917 3051 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_867 0518-0118 155 µM -0.33454331750162 0.402060619815492 no 2051 0.368984804635275 3084 6848158
SGTC_1877 wortmannin 25 µM -0.334718088547547 0.401989734633108 no 2052 0.368918877546206 3130 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2921 7974240 10.71 µM -0.334885426339793 0.40192186731628 no 2053 0.368855758041166 3114 2979074 YDR527W RBA50
SGTC_2992 9074591 71.4286 µM -0.33548254988744 0.401679715579012 no 2054 0.368630552986752 3110 17741321
SGTC_305 1682-2595 20.8 µM -0.335653168815484 0.401610531350366 no 2055 0.368566212367248 3058 226033
SGTC_1461 k072-0203 53.8 µM -0.337056799970049 0.401041490513632 no 2056 0.368037041227105 3051 5418714
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.337152659543881 0.401002636086119 no 2057 0.368000911137869 2984 364106
SGTC_1717 st033143 58.0435 µM -0.338214728404994 0.40057221701567 no 2058 0.367600688764026 3170 674616
SGTC_986 1493-0483 84 µM -0.340521307298934 0.399637858275715 no 2059 0.366731989796849 3110 40079
SGTC_3270 9137563 49.47 µM -0.34079435667473 0.399527288202317 no 2060 0.366629199575302 3083 17015724
SGTC_1333 1482-0047 286 µM -0.340799912115143 0.399525038636199 no 2061 0.366627108313064 3142 3811116
SGTC_2256 7954252 200 µM -0.341501864848887 0.399240823571548 no 2062 0.366362900608055 3072 2972920
SGTC_815 1582-0027 36.9 µM -0.342107828455682 0.398995516678492 no 2063 0.366134873137598 3097 3128206
SGTC_1296 1068-0102 11.9 µM -0.34244377544427 0.398859535407309 no 2064 0.366008474781535 3099 767053
SGTC_2077 5212015 200 µM -0.342777468575485 0.398724478581764 no 2065 0.36588293882229 2965 780900
SGTC_3251 9135047 49.47 µM -0.34285103980217 0.39869470346458 no 2066 0.365855263125174 3088 17682963
SGTC_2811 7967822 32.47 µM -0.343771201779904 0.398322353241544 no 2067 0.365509179689295 3161 2232244
SGTC_2999 9069765 71.4286 µM -0.344812927504218 0.397900923088829 no 2068 0.365117506856424 3078 2097066
SGTC_3174 9107204 49.47 µM -0.345816442930468 0.397495063530921 no 2069 0.364740333522114 3142 3938802
SGTC_680 0417-1641 114 µM -0.348116783511751 0.396565138176471 no 2070 0.363876240154542 2988 2835990
SGTC_482 fipronil 114 µM -0.349370853852874 0.396058420656928 no 2071 0.363405455821877 3071 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1214 0358-0031 63.7 µM -0.350904807341148 0.39543885282566 no 2072 0.362829882404504 3259 4301366
SGTC_2745 rifampicin 24.3 µM -0.350998704155458 0.395400936221333 no 2073 0.362794660282252 3062 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3263 9137018 49.47 µM -0.351574414727582 0.395168479387228 no 2074 0.362578727884198 3076 43844957
SGTC_1842 st055362 61.2 µM -0.352052213992514 0.394975584893696 no 2075 0.362399552370153 3025 676032
SGTC_1249 0481-0015 10.2 µM -0.352198025421852 0.39491672382839 no 2076 0.362344878843269 2988 4227577
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.35266860399158 0.394726777335806 no 2077 0.362168449623443 3336 5282309
SGTC_446 go6976 132 µM -0.35423206423953 0.394095874977103 no 2078 0.36158248784681 3149 3501 A protein kinase C inhibitor.
SGTC_1819 st053448 58.6 µM -0.354476248863809 0.3939973643136 no 2079 0.361491000321595 3032 2857616
SGTC_1149 3909-7961 23.3 µM -0.354859319174501 0.393842837085246 no 2080 0.36134749309491 3051 735261
SGTC_2731 amoxapine 43.43 µM -0.355236785503456 0.393690586802744 no 2081 0.361206104333176 3090 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2611 pyromycin 23.93 µM -0.355878037483715 0.393431976373998 no 2082 0.360965952010461 3044 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2088 5278280 127.392 µM -0.356231340120721 0.393289513075931 no 2083 0.36083366167612 3125 791502
SGTC_2063 5246145 200 µM -0.356342485114312 0.39324469869517 no 2084 0.360792048082576 3146 711240
SGTC_2808 7946468 45.46 µM -0.356488551158695 0.393185806071789 no 2085 0.360737362268602 3104 2970879
SGTC_651 3253-0966 34.4 µM -0.35718672353665 0.392904342518331 no 2086 0.36047601215719 3046 781462
SGTC_344 k064-0035 6.43 µM -0.357219517513382 0.392891123220082 no 2087 0.360463737836952 3026 5088750
SGTC_1889 st059080 5.18 µM -0.357232373249988 0.392885941088238 no 2088 0.360458926156358 3210 176925 Isolated from Daphnopsis sellowiana.
SGTC_3218 9131285 49.47 µM -0.35772528040035 0.392687265139916 no 2089 0.36027445617963 3214 17156417
SGTC_2270 7924575 90.91 µM -0.359575179717854 0.391941876498885 no 2090 0.359582423733211 3175 1262135
SGTC_3120 9124077 49.47 µM -0.359784854716037 0.391857416126825 no 2091 0.359504015000167 3072 18774327 YGL155W CDC43
SGTC_2870 9038528 12.99 µM -0.363311878639383 0.390437442513227 no 2092 0.35818596042914 3156 6463316
SGTC_3319 9138450 16.7555 µM -0.364427429461886 0.38998862677169 no 2093 0.357769427953054 3036 2029690
SGTC_1368 1852-0141 284 µM -0.36489708072161 0.38979971741215 no 2094 0.357594116767601 3160 2838987
SGTC_1063 disulfiram 1.84 µM -0.364927450497688 0.389787502573501 no 2095 0.357582781386649 3063 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3304 9125678 46.087 µM -0.364984437981168 0.389764582286168 no 2096 0.357561511406377 3034 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1583 clindamycin 39.6 µM -0.368126990529878 0.388501247522186 no 2097 0.356389273165074 3051 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.369273869387321 0.388040484598461 no 2098 0.35596180025822 3174 688664
SGTC_2855 9016525 58.44 µM -0.369502383856215 0.387948696849886 no 2099 0.355876648317349 3012 43811474
SGTC_1189 1431-2119 7.28 µM -0.369896925414546 0.387790235488999 no 2100 0.35572964619522 3091 3107275
SGTC_1852 st056254 31.4 µM -0.369951181967072 0.387768445665911 no 2101 0.355709432439822 3045 442583
SGTC_474 dl-dihydrosphingosine 5 µM -0.369974791047708 0.387758964199083 no 2102 0.35570063679606 3203 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_129 0088-0017 176.636 µM -0.370461743801207 0.387563417668432 no 2103 0.355519238022176 3177 182446
SGTC_2308 7584454 197.62 µM -0.370518328879198 0.387540696541105 no 2104 0.355498161170867 3237 893577
SGTC_445 e6 berbamine 66 µM -0.370953799150735 0.387365851046827 no 2105 0.355335971675434 3145 6610268 A calcium/calmodulin antagonist.
SGTC_3282 9108498 15.4605 µM -0.371519619230064 0.387138702983628 no 2106 0.35512527295354 3141 16459645
SGTC_966 1300-0360 30.2 µM -0.3720536218929 0.386924363440927 no 2107 0.354926462945248 3060 70588
SGTC_1981 st071826 47 µM -0.374719775543998 0.385854731973898 no 2108 0.353934441692533 3125 11838600
SGTC_2516 gossypol 71.55 µM -0.374742312667316 0.385845694013576 no 2109 0.353926060303437 3195 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_285 1486-1325 46 µM -0.375089643411968 0.385706413379949 no 2110 0.353796899528231 3176 22310230
SGTC_726 3448-4391 34.2 µM -0.375967890489677 0.385354299531767 no 2111 0.353470383683844 3243 1356692
SGTC_3118 9124250 49.47 µM -0.376156732951632 0.385278599632951 no 2112 0.353400189660685 3086 1504786
SGTC_544 k015-0020 52.4 µM -0.376389650577176 0.385185237665759 no 2113 0.353313619468082 3110 3008304
SGTC_1171 0368-0077 21.4 µM -0.376714110094807 0.385055193427678 no 2114 0.35319303788293 3047 3239779
SGTC_697 0508-1955 564 µM -0.378987128732145 0.384144524776685 no 2115 0.352348710967443 3234 6243113
SGTC_2085 5307070 144.047 µM -0.381913911756704 0.382972872111608 no 2116 0.351262610489486 3055 2840351
SGTC_1079 idarubicin 2.36 µM -0.383464870146341 0.382352423927672 no 2117 0.350687556385073 3198 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3233 9132340 49.47 µM -0.383465075204228 0.382352341915874 no 2118 0.350687480377644 3073 17682950
SGTC_2467 5474540 200 µM -0.384016584664216 0.382131787779913 no 2119 0.350483077704662 3067 5413519
SGTC_1399 3562-5772 25 µM -0.384737242027862 0.38184364735241 no 2120 0.3502160499927 3031 23847490
SGTC_1218 1348-1416 30.7 µM -0.385266043000036 0.381632258485499 no 2121 0.350020158587322 3071 6787668
SGTC_1881 5652484 16 µM -0.385764148769676 0.381433172346794 no 2122 0.349835674547128 3207 2255129
SGTC_1418 3966-3099 2.4 µM -0.38593980163229 0.381362973751976 no 2123 0.349770626234296 3168 740335
SGTC_843 0310-0051 143 µM -0.386077917042802 0.381307779511649 no 2124 0.349719482003809 3120 2065037
SGTC_3 0833-0587 95.581 µM -0.387288972280824 0.380823916209923 no 2125 0.349271144310708 3138 5382644
SGTC_124 0136-0217 7.121 µM -0.388055718582859 0.380517667749869 no 2126 0.348987400288249 3260 3976905
SGTC_80 0159-0065 512.242 µM -0.389469821934219 0.37995305293724 no 2127 0.348464315230287 3178 1548079
SGTC_1237 0330-0133 46.1 µM -0.390456423419756 0.379559279940629 no 2128 0.348099536114419 3058 X1237 YHR072W ERG7
SGTC_669 0108-0021 26.2 µM -0.391023367316109 0.379333057415496 no 2129 0.347889981797904 3403 17201
SGTC_2143 5623677 140.463 µM -0.394823394202433 0.377817836763911 no 2130 0.346486614293734 3185 5375313
SGTC_1731 st035964 63 µM -0.396173416269866 0.377279980587007 no 2131 0.345988550521258 3097 6739575
SGTC_2512 diallyl trisulfide 49.23 µM -0.396538999559507 0.377134371106878 no 2132 0.345853721634067 3163 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2662 daunorubicin 22.37 µM -0.399076826874669 0.376124053346609 no 2133 0.344918298217032 3123 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_952 1185-0122 232 µM -0.399320643199191 0.376027033790727 no 2134 0.344828479191081 3079 678600
SGTC_341 1486-1430 230 µM -0.399398198532649 0.375996174562488 no 2135 0.344799910564164 3047 2054753 YPL210C SRP72
SGTC_906 1165-0455 526 µM -0.402342843221674 0.374825090192764 no 2136 0.343715864130864 3118 3252859
SGTC_198 3454-2873 16.191 µM -0.40364351824941 0.374308178669012 no 2137 0.343237439677279 3130 710957
SGTC_2149 5554786 194.827 µM -0.404979716313421 0.373777384845993 no 2138 0.342746210361387 3127 745063 YPR165W RHO1
SGTC_62 0180-0423 3.232 µM -0.404994843748077 0.373771376963579 no 2139 0.342740650550591 3150 30102 YGL099W LSG1
SGTC_401 neomycin 50 µM -0.405970537493857 0.373383943635429 no 2140 0.342382124228725 3148 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3100 9120536 49.47 µM -0.411286362478546 0.371275366467332 no 2141 0.340431284131572 3175 16421196
SGTC_1022 4477-0945 21.3 µM -0.41182344706955 0.3710625398284 no 2142 0.340234417137398 3126 4648966
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.412127878538749 0.370941922469788 no 2143 0.340122847885435 3108 4000243
SGTC_972 1319-0219 195 µM -0.41621503447503 0.369323801843008 no 2144 0.338626329624696 3198 23903702
SGTC_1247 0448-0043 5.84 µM -0.417075683313643 0.368983361455356 no 2145 0.33831152527555 3234 3089013 YGL099W LSG1
SGTC_1308 1187-1617 41.4 µM -0.417310668259761 0.368890428075005 no 2146 0.33822559314157 3110 2882570
SGTC_683 panaxydol 45 µM -0.41922342984314 0.36813424221481 no 2147 0.337526425173643 3157 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1031 k035-0009 16 µM -0.421749492508054 0.367136378425009 no 2148 0.336603937580663 3287 5180959
SGTC_1980 st071811 45.7 µM -0.421915891964369 0.367070677503252 no 2149 0.336543204938434 3294 4974850
SGTC_994 3910-0338 138 µM -0.422062745561136 0.367012697274146 no 2150 0.336489609705645 3306 3479481
SGTC_958 1222-0007 33 µM -0.423230688649739 0.36655168211069 no 2151 0.336063479164875 3294 7312461
SGTC_1612 st002233 45.4 µM -0.423547028879105 0.366426848129526 no 2152 0.335948096894027 3241 1035021
SGTC_524 r073-0010 27.8 µM -0.424558029682476 0.366027982441376 no 2153 0.335579447083039 3091 2772106
SGTC_354 2783-3500 4.88 µM -0.426591229818454 0.365226271576184 no 2154 0.334838543354798 3161 6740761
SGTC_995 3931-2021 34.6 µM -0.427039373340881 0.365049643215019 no 2155 0.334675324926803 3227 730143
SGTC_2147 5545932 89.7195 µM -0.429388353144382 0.364124300748651 no 2156 0.333820314119122 3208 797404
SGTC_2386 9075165 157.42 µM -0.430149804875907 0.363824508828696 no 2157 0.333543336279744 3213 16452277
SGTC_3007 9078383 71.4286 µM -0.430228770126117 0.363793424107816 no 2158 0.333514617882396 3163 6496995
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.43063904385185 0.363631934027631 no 2159 0.333365423602637 3235 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1547 harmine 94.2 µM -0.431616855051881 0.363247150143375 no 2160 0.333009953059883 3199 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2748 diazoxide 86.69 µM -0.432769652362779 0.362793683735881 no 2161 0.332591061269594 3204 3019 A potassium channel activatior.
SGTC_2016 5121758 140 µM -0.433001262191738 0.36270260046449 no 2162 0.332506926430463 3194 2795203
SGTC_288 1315-0019 35.1 µM -0.433932898385229 0.362336302163879 no 2163 0.332168584514208 3281 6811474
SGTC_1488 4013-0813 75.9 µM -0.43417136989772 0.362242560795018 no 2164 0.332082000890414 3186 2910057
SGTC_1457 k015-0032 57.3 µM -0.43457514453305 0.36208385884143 no 2165 0.331935419874249 3201 4302660
SGTC_1774 st048371 48.465 µM -0.435566735625917 0.361694218704977 no 2166 0.331575554899963 3129 4242727
SGTC_601 0986-0029 62.9 µM -0.436576537325932 0.361297570132938 no 2167 0.331209240694401 3198 24747981
SGTC_283 0987-0079 11.7 µM -0.437780114592787 0.360825001538344 no 2168 0.330772843672112 3270 411556
SGTC_1301 naphtanilide LB 4.81 µM -0.438804326042396 0.360423025793577 no 2169 0.330401662724051 3292 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_832 4083-0019 164 µM -0.441510226852442 0.359361774672491 no 2170 0.329421829713927 3290 1990758
SGTC_755 1995-0008 37.3 µM -0.441529172415702 0.359354348056901 no 2171 0.329414973458617 3286 689533
SGTC_2495 cafestol 54.53 µM -0.442642990394003 0.358917827537917 no 2172 0.329011992067112 3323 16667697 An anti-infammatory.
SGTC_2606 farnesol 9.78 µM -0.443177463635981 0.358708425511924 no 2173 0.328818689166847 3323 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2216 7189485 200 µM -0.44394997458371 0.358405837413967 no 2174 0.328539376104265 3277 731273
SGTC_1898 st060199 18.6 µM -0.44436949864747 0.358241549479234 no 2175 0.328387730929968 3173 688866
SGTC_2962 9082311 13.18 µM -0.444588510693348 0.358155793578824 no 2176 0.328308575973568 3140 16459453
SGTC_2624 nerol 100 µM -0.447041588604606 0.357195761324135 no 2177 0.327422516085546 3202 637566 A natural product oil.
SGTC_1830 st055982 50.3 µM -0.447900500575321 0.356859832246488 no 2178 0.327112503556706 3297 455313 An antimicrobial agent.
SGTC_2667 digitoxin 100 µM -0.448943920389531 0.356451889601933 no 2179 0.326736055877407 3259 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_769 0302-0231 76 µM -0.449182584968684 0.356358602699342 no 2180 0.326649974620826 3296 571869 YER009W NTF2
SGTC_2933 9026794 32.47 µM -0.449461353569196 0.35624965120733 no 2181 0.326549440377707 3195 17586027
SGTC_3072 9116419 49.47 µM -0.450269648284784 0.355933810703977 no 2182 0.32625801070996 3228 17170162
SGTC_539 4859-0462 2.54 µM -0.451553062373287 0.355432520841586 no 2183 0.325795495265568 3313 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_64 000l-0018 272.079 µM -0.451640691892311 0.35539830265697 no 2184 0.325763925195779 3192 6811119
SGTC_3074 9116018 49.47 µM -0.451817808862409 0.355329144348741 no 2185 0.325700119518609 3164 17027303
SGTC_1983 st071813 46.9 µM -0.452292414159706 0.355143850197919 no 2186 0.325529170042251 3247 11838595
SGTC_1471 k673-0312 37 µM -0.452903904892877 0.354905164088627 no 2187 0.325308969495303 3252 24099884
SGTC_2106 5357045 167.29 µM -0.454724231703508 0.354194964544147 no 2188 0.3246538228588 3261 668842
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.455560763367149 0.353868761977668 no 2189 0.324352931739507 3226 88881 An O-methylated flavonoid and antioxidant.
SGTC_1464 k208-0027 110 µM -0.456960026256104 0.353323364177839 no 2190 0.323849888818083 3384 X1464
SGTC_1384 3089-0840 101 µM -0.457328635329291 0.353179739606194 no 2191 0.32371742524958 3299 1069836
SGTC_649 1123-0311 367 µM -0.458785065538364 0.352612461905011 no 2192 0.323194260189762 3277 693629 YIL048W NEO1
SGTC_1441 4106-0040 13 µM -0.458956915148601 0.352545548286267 no 2193 0.323132553033549 3259 2904180
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.459251903402688 0.352430698428524 no 2194 0.323026641032185 3308 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2303 7774051 200 µM -0.46054542970553 0.351927239670904 no 2195 0.322562385388779 3361 2953184
SGTC_1014 4130-3005 69.3 µM -0.462350295938365 0.35122519395001 no 2196 0.321915068436967 3184 743608
SGTC_2735 sertaconazole 140 nM -0.46321466481896 0.350889156605265 no 2197 0.321605252845859 3286 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2395 5646831 180.19 µM -0.465144285390885 0.35013940649236 no 2198 0.320914067013413 3381 6808628
SGTC_1268 0828-0275 2.46 µM -0.465480376882092 0.350008878442382 no 2199 0.320793743134437 3307 745337
SGTC_2005 4024620 188 µM -0.465578484814219 0.349970779547827 no 2200 0.320758623131168 3259 236743
SGTC_2182 6325192 200 µM -0.465918637539699 0.349838697514558 no 2201 0.320636870020503 3308 736248
SGTC_1938 st074717 56.4 µM -0.468258484895854 0.348930622889418 no 2202 0.319799876440472 3264 17250979
SGTC_2782 7736369 71.43 µM -0.468685696210996 0.348764919035944 no 2203 0.319647156286885 3239 2950836 YOL077C BRX1
SGTC_1282 0886-0010 32.4 µM -0.469742118668977 0.348355284903007 no 2204 0.319269636106877 3388 2836211 YNL267W PIK1
SGTC_27 0485-0001 32.618 µM -0.470657306715203 0.348000558169613 no 2205 0.318942738460504 3284 2054479
SGTC_1476 4112-3294 3.34 µM -0.471296065900051 0.347753053987864 no 2206 0.31871466233549 3344 704369
SGTC_599 1935-0052 86.5 µM -0.471819642530656 0.347550228712124 no 2207 0.318527764626982 3204 9557311
SGTC_3213 9129884 49.47 µM -0.472416020218402 0.347319254621401 no 2208 0.31831493584488 3282 17190742
SGTC_2784 7567673 72.73 µM -0.47341831006616 0.346931200516963 no 2209 0.317957384626242 3338 3471247
SGTC_1113 artemisinin 1.17947 µM -0.476587005591039 0.345705441792424 no 2210 0.316828119176128 3327 2240 An anti-malaria and mitochondrial poison.
SGTC_339 3091-4833 71.4 µM -0.477484773993814 0.345358447749331 no 2211 0.316508480266116 3298 3240077
SGTC_896 0964-0007 44.5 µM -0.477609576858381 0.345310220811371 no 2212 0.316464056649987 3334 6756758
SGTC_909 3448-9333 149 µM -0.478324514704977 0.34503399943017 no 2213 0.316209625361557 3225 3344074
SGTC_196 k015-0023 18.111 µM -0.479429803549157 0.344607125641551 no 2214 0.315816447635797 3229 5211998
SGTC_2090 5301565 104.445 µM -0.479833999948242 0.344451070246747 no 2215 0.315672717285442 3257 2056344
SGTC_2123 5259487 200 µM -0.483558409203324 0.343014369240055 no 2216 0.31434964879055 3348 2173474
SGTC_2508 celastrol 40.54 µM -0.484039064125311 0.342829120003899 no 2217 0.314179072875813 3276 122724 Celastrol is a natural product and antioxidant.
SGTC_736 0958-0254 92.6 µM -0.48406361689538 0.342819658133564 no 2218 0.314170360597785 3378 6812352
SGTC_513 4245-1575 41.7 µM -0.487374964657651 0.341544473606624 no 2219 0.312996315906238 3277 719745
SGTC_616 4092-0450 108 µM -0.488340798420949 0.341172875196176 no 2220 0.312654233893169 3312 787165
SGTC_2109 5483026 200 µM -0.489994582224354 0.340536950080845 no 2221 0.312068866295979 3291 759335
SGTC_774 k060-0086 136 µM -0.490056680135301 0.340513080549824 no 2222 0.312046895562852 3404 5911235
SGTC_265 mycophenolic acid 32.932 µM -0.491041127585279 0.340134758703977 no 2223 0.311698679609863 3485 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2478 5763493 32.33 µM -0.491294552961143 0.340037393693999 no 2224 0.311609065933572 3260 1365576 YLR208W SEC13
SGTC_1733 st037357 54.9 µM -0.491625449204809 0.339910280746089 no 2225 0.311492074600003 3167 1272339 YGL099W LSG1
SGTC_172 1112-0046 2.638 µM -0.493225181529898 0.339296004549176 no 2226 0.310926743465732 3232 2802135 YIL048W NEO1
SGTC_236 1509-0011 5.31 µM -0.495240136800278 0.338522895693889 no 2227 0.31021531088674 3440 3107280
SGTC_1539 benzyladenosine 56 µM -0.495538145180638 0.338408611887393 no 2228 0.310110151426025 3276 92208 A nucleotide analog.
SGTC_558 k064-0027 21.3 µM -0.495545645218172 0.338405735875532 no 2229 0.310107505056773 3331 5088526
SGTC_3092 9117248 49.47 µM -0.496123069708247 0.338184341336785 no 2230 0.309903791824237 3351 17141857
SGTC_404 fumagillin 50 µM -0.497907133070291 0.337500654304154 no 2231 0.309274749721291 3322 12015870 A methionine aminopeptidase binder.
SGTC_2081 5214970 32.255 µM -0.498263115154022 0.337364299276598 no 2232 0.309149300951 3354 2063512
SGTC_3105 9121040 49.47 µM -0.498458514988625 0.33728946259324 no 2233 0.309080451131209 3301 41448907
SGTC_3112 9123419 49.47 µM -0.498669542335029 0.337208647918918 no 2234 0.309006102434103 3368 17015854
SGTC_796 1234-0020 70.7 µM -0.49977657519867 0.336784823619552 no 2235 0.308616203244839 3339 46495034
SGTC_1806 st050005 60.3 µM -0.503093537939418 0.335516176301136 no 2236 0.307449254895773 3296 5194765
SGTC_1497 4476-2978 41.3 µM -0.503876850036701 0.335216853739889 no 2237 0.307173959693238 3366 1528379
SGTC_370 0180-0345 38.7 µM -0.504727902156354 0.33489176462727 no 2238 0.306874980383467 3240 3989527
SGTC_1286 0929-0070 131 µM -0.505628717434495 0.334547801474748 no 2239 0.306558658884827 3397 1420408
SGTC_1033 k072-0102 21.3 µM -0.506188737350133 0.33433403600919 no 2240 0.306362080357118 3388 5965931
SGTC_1071 trifluoperazine 6.31 µM -0.506245307430956 0.334312445602742 no 2241 0.306342226190945 3413 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1747 st037496 66.6 µM -0.506413567667178 0.334248231029329 no 2242 0.306283175955946 3273 723305
SGTC_61 0978-8327 98.565 µM -0.506719772268659 0.334131384031059 no 2243 0.306175727626131 3388 6150059 YHR072W ERG7
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.507844628219288 0.33370227954885 no 2244 0.305781154662697 3287 390807
SGTC_1372 2752-0194 270 µM -0.510726063416623 0.332604076803263 no 2245 0.304771443884852 3373 823334
SGTC_2220 6782180 200 µM -0.510752701530798 0.332593930886972 no 2246 0.304762116290306 3333 833803
SGTC_3143 9086658 49.47 µM -0.510998119303023 0.332500462015417 no 2247 0.304676186843501 3355 25236626
SGTC_3355 9151058 44.0485 µM -0.51155648475872 0.332287843895693 no 2248 0.304480723491522 3386 17015728
SGTC_529 4076-0302 30.3 µM -0.512671271746031 0.331863509356652 no 2249 0.30409064431341 3295 5816522
SGTC_3017 9080681 49.47 µM -0.51378507925152 0.331439762938863 no 2250 0.303701130449646 3355 16451914
SGTC_2709 st078560 56 µM -0.514036551412053 0.331344120553353 no 2251 0.303613217985702 3447 17250903
SGTC_2440 5628896 157.78 µM -0.514181902528739 0.331288844191077 no 2252 0.303562409690774 3298 5522048
SGTC_910 3454-3003 490 µM -0.514246033191245 0.33126445676315 no 2253 0.303539993666599 3401 820824
SGTC_1402 3909-7673 35.9 µM -0.5159864785151 0.330602878652796 no 2254 0.302931926535865 3351 5328014
SGTC_1552 6-methylflavone 10.6 µM -0.519723444663865 0.32918417210095 no 2255 0.301628171940039 3402 689013
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.520204569626959 0.329001695273407 no 2256 0.301460500355828 3372 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3042 9091578 49.47 µM -0.521995954128972 0.328322633329103 no 2257 0.300836573781185 3381 25236497
SGTC_63 0099-0242 26.702 µM -0.521999017611604 0.328321472536501 no 2258 0.300835507290885 3420 3898502 YLR359W ADE13
SGTC_1749 st037932 54.2 µM -0.523082751636973 0.327910935980156 no 2259 0.300458334003148 3400 594497
SGTC_783 0848-0141 92.7 µM -0.524068552797783 0.327537678538503 no 2260 0.300115430053625 3375 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2261 9010538 184.68 µM -0.526447919908428 0.326637480627677 no 2261 0.299288514151164 3379 6457250
SGTC_253 dyclonine 31.25 µM -0.527217209963474 0.32634664672534 no 2262 0.299021379389515 3409 3180 An oral anasthetic.
SGTC_2834 9001755 58.44 µM -0.528212384185788 0.325970572800655 no 2263 0.298675967425544 3267 2989575
SGTC_3033 9090887 49.47 µM -0.528269910234754 0.325948839253134 no 2264 0.298656006433273 3333 19325384
SGTC_2356 9061756 188.97 µM -0.528357774391938 0.325915645000944 no 2265 0.298625519576599 3357 20104043
SGTC_2252 omeprazole 400 µM -0.528601529174487 0.325823563960692 no 2266 0.298540949641681 3279 4594 A proton pump inhibitor.
SGTC_1202 1988-0068 29.6 µM -0.529686927439003 0.325413671913248 no 2267 0.298164506549221 3307 2850480
SGTC_3144 9087057 49.47 µM -0.530409022653871 0.325141095273055 no 2268 0.297914185815624 3391 17249618
SGTC_714 4296-0578 26.1 µM -0.530685639520106 0.325036702658767 no 2269 0.297818319504965 3348 1589775
SGTC_1410 3909-8106 77.9 µM -0.531267984809709 0.324816975900772 no 2270 0.297616543777196 3410 1039210
SGTC_2022 5136654 200 µM -0.532434611518279 0.324376975231741 no 2271 0.29721250929234 3396 1713771
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.532492733298397 0.32435506063796 no 2272 0.29719238670058 3244 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2545 solidagenone 89.61 µM -0.532893187643566 0.324204087404947 no 2273 0.297053760607283 3290 6708572 An anti ulcer agent
SGTC_777 1315-0167 517 µM -0.536212523803794 0.322953796094196 no 2274 0.295905839501546 3378 4221767
SGTC_3000 9075062 71.4286 µM -0.537609503282981 0.322428193681752 no 2275 0.295423333981783 3324 17057871
SGTC_3156 9099931 49.47 µM -0.53784910545187 0.322338080883594 no 2276 0.295340613686449 3316 18111053
SGTC_2287 7945887 168.79 µM -0.538382899815742 0.322137361878184 no 2277 0.29515636475702 3394 1245853
SGTC_2974 9094440 9.66 µM -0.539755092163929 0.321621624001675 no 2278 0.294682970429846 3474 25236134
SGTC_3013 9080133 71.4286 µM -0.540757548961558 0.321245068181409 no 2279 0.294337353143235 3511 17050193
SGTC_542 3381-0244 89.3 µM -0.540959892322359 0.321169083613245 no 2280 0.294267613882 3477 1112843
SGTC_3324 9138759 60.749 µM -0.542164999681052 0.3207166933432 no 2281 0.293852422149785 3443 45595710
SGTC_2717 st081029 62.2815 µM -0.542405570774388 0.320626416203804 no 2282 0.293769571428309 3442 5292846
SGTC_1659 st012954 42.1 µM -0.544232394739068 0.31994122545475 no 2283 0.293140781131385 3442 24207262
SGTC_2140 5586273 200 µM -0.545216956062597 0.319572198336523 no 2284 0.292802155509283 3422 854421
SGTC_2058 5236698 133 µM -0.548763798725949 0.318244275535171 no 2285 0.29158377846675 3352 766665
SGTC_2191 5911152 200 µM -0.549834500506785 0.317843866885651 no 2286 0.291216446405519 3393 2875902
SGTC_276 colchicine 750 µM -0.550012323356082 0.317777387359364 no 2287 0.291155460583427 3491 2833 A microtubule depolymerizer.
SGTC_1968 st069590 43.6 µM -0.550121874201682 0.317736434419795 no 2288 0.291117892180677 3422 6384066
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.551137267910299 0.317356960151997 no 2289 0.290769789783543 3461 688798
SGTC_1729 st035615 45.989 µM -0.552469322086527 0.316859434146949 no 2290 0.2903134236096 3390 17385451
SGTC_1725 st036284 20.55 µM -0.55258159392128 0.316817515412223 no 2291 0.290274974239933 3500 707914
SGTC_901 1112-0062 60.1 µM -0.552583059565442 0.316816968202825 no 2292 0.290274472321321 3407 1908457
SGTC_499 genistein 192 µM -0.553546905539209 0.316457195816235 no 2293 0.289944485570028 3443 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_600 1495-0418 41.6 µM -0.554041926988766 0.316272487852 no 2294 0.289775076143702 3402 5377768
SGTC_656 4090-1979 187 µM -0.554176011895467 0.316222464472086 no 2295 0.289729196738743 3488 22330961
SGTC_1037 k284-1091 78.7 µM -0.55449698180241 0.316102733117154 no 2296 0.289619385337643 3455 3334711
SGTC_2254 7938975 95.19 µM -0.554527559877489 0.316091327588387 no 2297 0.289608924873937 3528 2969277
SGTC_1413 3910-0535 34.4 µM -0.554674492592549 0.31603652457493 no 2298 0.289558663087352 3454 2876951
SGTC_811 0416-0114 265 µM -0.555044585415452 0.315898505144741 no 2299 0.28943208229795 3453 6612453
SGTC_374 0880-0231 82.3 µM -0.555375744551016 0.315775027082676 no 2300 0.289318839821174 3425 6833587
SGTC_1967 st070177 51.4 µM -0.555668369969418 0.315665934050823 no 2301 0.289218791583951 3489 5729214
SGTC_132 0417-1715 25.805 µM -0.557162228063837 0.315109262558215 no 2302 0.28870829712283 3511 6769098
SGTC_921 1561-0023 372 µM -0.557784800014724 0.314877391064848 no 2303 0.288495671644225 3450 24050882
SGTC_3305 9127027 53.8275 µM -0.558405780531034 0.314646184957574 no 2304 0.288283663225265 3350 41905295
SGTC_2932 9016711 44.54 µM -0.558596586423885 0.314575157883865 no 2305 0.288218535110704 3466 7117328
SGTC_3034 9090421 49.47 µM -0.558667007751957 0.314548945432854 no 2306 0.28819449982719 3420 17173761
SGTC_709 3807-1509 243 µM -0.558712377278372 0.314532058338332 no 2307 0.288179015396681 3470 1886677 YPL242C IQG1
SGTC_403 arphamenine a 50 µM -0.559182287726055 0.314357174729677 no 2308 0.288018660006621 3426 5487158 An arginine aminopeptidase inhibitor.
SGTC_628 1636-0253 16 µM -0.559648666796012 0.314183646559878 no 2309 0.287859551344119 3420 4456143
SGTC_2941 9056145 11.23 µM -0.561636422061119 0.31344451264334 no 2310 0.287181879885523 3429 2119517
SGTC_973 1325-0077 65.9 µM -0.561763310194728 0.313397355499432 no 2311 0.287138646459046 3435 2835149
SGTC_722 3534-0461 190 µM -0.562023449427903 0.31330068599501 no 2312 0.287050021246809 3426 658262
SGTC_2377 9073351 62.6 µM -0.563547224580689 0.312734698594161 no 2313 0.286531156149774 3370 7337946 YHR072W ERG7
SGTC_1272 0839-0021 27 µM -0.564199486977096 0.312492558590831 no 2314 0.286309188465827 3432 5027250
SGTC_2214 7179297 48.276 µM -0.564980888969525 0.31220258452286 no 2315 0.286043381556148 3462 769744
SGTC_2316 5844804 197.44 µM -0.565538864160966 0.311995594095902 no 2316 0.285853648788598 3450 776813
SGTC_2424 5537928 59.2 µM -0.566128845729833 0.311776794911977 no 2317 0.285653097748499 3409 5382802
SGTC_1674 st016616 23.6 µM -0.566192555783032 0.311753171522973 no 2318 0.285631444946508 3399 625830
SGTC_2634 4'-methoxyflavone 100 µM -0.567443526543881 0.311289474454935 no 2319 0.285206442377251 3412 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_500 h-89 112 µM -0.567636083939372 0.311218125806404 no 2320 0.285141050044317 3532 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1002 4049-0206 172 µM -0.569695843795528 0.31045536330752 no 2321 0.284442004750426 3435 4662749
SGTC_1957 st077035 62.4 µM -0.570382293490722 0.310201340603896 no 2322 0.284209218156269 3526 705593
SGTC_214 4373-3496 70 µM -0.571773798623531 0.30968668795261 no 2323 0.283737615116294 3546 3779166
SGTC_2884 9058502 51.95 µM -0.572245621489703 0.309512267347058 no 2324 0.283577792022784 3486 6471554
SGTC_1880 MG-132 525 µM -0.572287531766651 0.309496776284899 no 2325 0.283563597615703 3473 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.572381811508798 0.309461929426313 no 2326 0.283531667669514 3591 16725076
SGTC_1129 3453-1384 223 µM -0.57460341221124 0.308641297056644 no 2327 0.282779771912736 3531 1084452
SGTC_803 4488-1585 147 µM -0.576047589198829 0.308108347343294 no 2328 0.282291507752038 3467 747204
SGTC_626 0214-0009 33 µM -0.57625106765632 0.308033289447144 no 2329 0.282222746005506 3503 3437874
SGTC_1706 st031321 9.9705 µM -0.57638735224502 0.30798302210614 no 2330 0.282176695680804 3487 6103185
SGTC_677 0929-0063 136 µM -0.577447872864023 0.307591981790955 no 2331 0.281818471251949 3448 1539583
SGTC_2517 totarol 10 µM -0.577876126691626 0.307434135871659 no 2332 0.281673877103225 3437 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2520 obtusaquinone 4.71 µM -0.578140223776067 0.307336812664044 no 2333 0.281584726106979 3568 5967872
SGTC_3191 9110352 49.47 µM -0.579572664696253 0.306809176033199 no 2334 0.281101415645903 3480 17122424
SGTC_3318 9139014 38.6185 µM -0.580634719780093 0.306418228403992 no 2335 0.280743333521732 3472 16643984
SGTC_2768 sulfasalazine 50.2 µM -0.581558936506824 0.306078198935019 no 2336 0.280431904554311 3549 5384001 An antioxidant and salicylic acid derivative.
SGTC_1094 duloxetine 25.4 µM -0.581646029779212 0.306046164971741 no 2337 0.280402565768655 3470 60834 A selective serotonin reuptake inhibitor.
SGTC_719 2810-4230 27.3 µM -0.586890323575915 0.304119990858739 no 2338 0.278638684494284 3464 721079
SGTC_1141 3253-0389 52.6 µM -0.588104977188325 0.303674632958166 no 2339 0.278230916282581 3478 5402031
SGTC_866 0495-0101 262 µM -0.588714278306522 0.30345133981321 no 2340 0.278026479028143 3397 635694
SGTC_629 3448-6466 76.7 µM -0.589189761843358 0.303277138331101 no 2341 0.277866992177422 3507 573744
SGTC_453 enantio-paf c16 10 µM -0.589214723909876 0.303267994288555 no 2342 0.277858620626535 3509 13871343 A lipid and platelet activating factor
SGTC_2206 7254556 146.969 µM -0.589673061513605 0.303100119102194 no 2343 0.277704929418258 3470 4398905
SGTC_3286 9117135 37.221 µM -0.591512079462572 0.302426960923808 no 2344 0.277088681980465 3406 3438150
SGTC_1985 st071382 65.5 µM -0.591526842702076 0.30242155966862 no 2345 0.277083737587976 3530 6123237
SGTC_2645 abamectin 100 µM -0.592239656903129 0.302160822092232 no 2346 0.276845058633736 3498 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2915 7971052 15.16 µM -0.592269709530455 0.302149831473951 no 2347 0.276834998014159 3418 5741558
SGTC_3190 9110366 49.47 µM -0.59235003797263 0.302120455248004 no 2348 0.276808107603808 3447 17123768
SGTC_914 3820-6779 408 µM -0.594157234165633 0.301459900246421 no 2349 0.276203476637527 3465 2893481
SGTC_2315 7733312 200 µM -0.595447432236708 0.300988713185981 no 2350 0.275772213883173 3448 726316
SGTC_3185 9108267 49.47 µM -0.596149589921407 0.300732421137034 no 2351 0.275537649167807 3501 4910486
SGTC_92 0063-0024 660.874 µM -0.596381724550498 0.300647712177214 no 2352 0.275460123227072 3536 3594437
SGTC_1436 4092-1007 8.32 µM -0.596791792591612 0.30049809931443 no 2353 0.275323199137452 3482 2881121
SGTC_570 0987-0065 62.6 µM -0.598540617623095 0.29986042031573 no 2354 0.274739632662728 3409 3104428
SGTC_885 0865-0106 16.8 µM -0.59889294867172 0.299732023030173 no 2355 0.27462213695735 3487 2793380
SGTC_386 1509-0011 3.07 µM -0.599831390969341 0.299390155295011 no 2356 0.274309305269162 3544 3107280
SGTC_1901 st060216 58.6 µM -0.600326462029393 0.299209875767672 no 2357 0.274144343225475 3534 688792
SGTC_696 1560-0013 611 µM -0.600607238105196 0.299107653395567 no 2358 0.274050807943348 3586 1650269
SGTC_1480 1070-0044 41.2 µM -0.601763557013191 0.298686838623396 no 2359 0.273665768271302 3493 3124987
SGTC_1134 3477-0009 42.5 µM -0.602882280206926 0.298279962291754 no 2360 0.273293502405202 3600 3973534
SGTC_3137 9097352 49.47 µM -0.603243625305494 0.298148596083434 no 2361 0.2731733149736 3640 44120435
SGTC_93 0109-0045 59.227 µM -0.604191344520479 0.297804180137605 no 2362 0.272858217410853 3579 88733
SGTC_2875 9039966 71.43 µM -0.604859003020065 0.297561651628638 no 2363 0.272636342684521 3499 6463691
SGTC_1324 1418-0026 34.4 µM -0.606201380222606 0.297074303061903 no 2364 0.272190518189472 3546 1372513
SGTC_1963 st076565 50.3 µM -0.607441610798264 0.296624363389407 no 2365 0.271778940477805 3538 4914280
SGTC_3109 9122853 49.47 µM -0.607863467768461 0.296471390289574 no 2366 0.271639015419528 3519 1234709
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.608522242711407 0.296232578714331 no 2367 0.271420579183931 3553 1273210
SGTC_1487 3970-0795 2.82 µM -0.609196026524246 0.295988417607621 no 2368 0.271197256879582 3550 3765103
SGTC_508 roscovitine 141 µM -0.610443568045158 0.295536586223424 no 2369 0.270784007413852 3542 160355 A CDKinase inhibitor.
SGTC_614 0462-0418 107 µM -0.611973408977253 0.294982945697013 no 2370 0.27027767543415 3435 5188303
SGTC_2796 7949634 45.45 µM -0.613127430045152 0.294565628639261 no 2371 0.269896042161895 3524 2971588
SGTC_3115 9123671 49.47 µM -0.613841248583167 0.294307634042298 no 2372 0.269660118398149 3611 3286988
SGTC_2108 5365811 200 µM -0.615384155839164 0.293750339746484 no 2373 0.269150526216258 3541 780283
SGTC_174 3553-0389 74.3 µM -0.616180208228537 0.293462998683245 no 2374 0.268887794715239 3553 738071
SGTC_95 0471-0001 561.058 µM -0.616204885735971 0.293454093233312 no 2375 0.268879652135608 3489 4015405
SGTC_2334 9017922 200 µM -0.617362831894669 0.293036362376177 no 2376 0.268497715992534 3529 3163164
SGTC_824 1304-0008 100 µM -0.61767715576484 0.292923017178287 no 2377 0.26839408671611 3539 768245
SGTC_3212 9128307 49.47 µM -0.618223350634689 0.29272610770113 no 2378 0.268214059864036 3379 27243542
SGTC_1199 1638-0010 4.46 µM -0.618516943439553 0.292620289556322 no 2379 0.268117316239347 3489 3111136
SGTC_2926 9010726 65.15 µM -0.618520213256133 0.292619111133218 no 2380 0.268116238880275 3525 2994293
SGTC_1074 carmofur 3.8 µM -0.618891065401495 0.292485472458945 no 2381 0.267994062397161 3586 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2583 asiatic acid 100 µM -0.620664613070665 0.291846757070779 no 2382 0.267410158591159 3584 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2683 piperine 63.03 µM -0.6212507001187 0.291635829934982 no 2383 0.267217342743338 3495 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1043 0916-0009 19.3 µM -0.621638725036639 0.291496222581397 no 2384 0.26708972565838 3598 3101130
SGTC_506 n9-isopropylolomoucine 153 µM -0.622993170508454 0.291009151568047 no 2385 0.266644504896088 3565 6610355
SGTC_310 1273-0058 1.06 µM -0.6234177846913 0.290856534736774 no 2386 0.266505006949675 3576 2734232
SGTC_146 3448-8650 53.125 µM -0.624221947052476 0.290567601479336 no 2387 0.266240917722344 3555 2891488 YIL048W NEO1
SGTC_528 3492-0019 172 µM -0.624413700770605 0.290498724747166 no 2388 0.266177964816296 3578 2869262
SGTC_1688 st021091 57.6 µM -0.625176307052099 0.290224877009006 no 2389 0.265927675143596 3566 3656366
SGTC_939 1165-0479 45.3 µM -0.625988590277841 0.28993332362968 no 2390 0.265661212561316 3518 1377347
SGTC_1251 0490-5699 265 µM -0.626263824283868 0.289834564860635 no 2391 0.265570955113509 3607 3883818
SGTC_1208 2323-2347 50.3 µM -0.626995483318006 0.289572109579202 no 2392 0.265331097925367 3571 5412760
SGTC_998 3996-0085 177 µM -0.628329837864498 0.289093747387322 no 2393 0.264893944517069 3563 715391
SGTC_1573 oleylamine 1.06 µM -0.628496693877937 0.289033956147185 no 2394 0.264839305889608 3569 5356789 An amine of the fatty acid oleic acid.
SGTC_630 4356-0227 183 µM -0.628929966201688 0.288878724366004 no 2395 0.264697453403148 3574 779312
SGTC_2549 cedrol 20.94 µM -0.630002934588073 0.288494472790053 no 2396 0.264346332116032 3535 6708665 A sedative which affects the nervous system.
SGTC_203 k066-0004 30.888 µM -0.631205820985026 0.288063981554369 no 2397 0.263952978195314 3629 6795412
SGTC_1557 sumaresinolic acid 42.3 µM -0.632688356397326 0.287533826470051 no 2398 0.263468587468518 3527 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3262 9137218 49.47 µM -0.634558006814433 0.28686589742306 no 2399 0.262858361724337 3445 17650664
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.635462140862683 0.286543161220964 no 2400 0.262563525455198 3570 2724 A muscle relaxant with antifungal properties.
SGTC_2949 9072542 2.23 µM -0.635788078687766 0.286426857966853 no 2401 0.262457279316376 3580 16457352
SGTC_2323 6148992 148.28 µM -0.637619143476598 0.285773902320116 no 2402 0.261860815507048 3519 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3127 9126946 49.47 µM -0.641051890754598 0.284551699816388 no 2403 0.260744484835162 3506 27243249
SGTC_43 0570-0105 72.5 µM -0.643563985906064 0.283658873023421 no 2404 0.259929105070069 3617 1114046 YDL195W SEC31
SGTC_568 1193-0097 7.48 µM -0.644243298261517 0.283417668490119 no 2405 0.25970883892843 3508 3646150
SGTC_1138 3761-0006 1.03 µM -0.644775174582006 0.283228882963351 no 2406 0.259536445995688 3579 12061087
SGTC_2526 patulin 37.61 µM -0.644848075115925 0.283203012164625 no 2407 0.25951282191845 3619 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2194 5927483 104.545 µM -0.64565035589111 0.28291837524732 no 2408 0.25925290895567 3602 760979
SGTC_2468 5987765 72.9 µM -0.646138890573584 0.282745117951545 no 2409 0.259094705484666 3591 26772094
SGTC_3228 9131799 49.47 µM -0.647014472989286 0.282434723005677 no 2410 0.258811288281448 3556 17015818
SGTC_2751 anetholtrithion 17.25 µM -0.648009089467296 0.282082329290174 no 2411 0.258489535689231 3567 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1642 st009582 77.7 µM -0.648229443459741 0.282004286284517 no 2412 0.2584182805117 3606 6739311
SGTC_1320 1313-0481 95.3 µM -0.648309362268474 0.281975983925849 no 2413 0.2583924399327 3623 6813365 YLR208W SEC13
SGTC_480 am 92016 50 µM -0.648647633274118 0.281856204159273 no 2414 0.258283079773401 3530 2129 K+ channel blocker.
SGTC_1611 st001856 99.4 µM -0.649597027892933 0.281520160158865 no 2415 0.257976276701196 3546 647478
SGTC_2945 9067681 61.76 µM -0.649837200239359 0.281435180336855 no 2416 0.257898693410573 3671 16456930
SGTC_668 1682-0499 62.6 µM -0.650030726701447 0.281366714164906 no 2417 0.257836187029696 3595 682214
SGTC_2098 5376439 882.5 nM -0.650277614950925 0.281279381226114 no 2418 0.257756456940488 3640 2844116
SGTC_2050 5263056 171 µM -0.651479760089703 0.280854327885445 no 2419 0.257368419141598 3596 763468 YGL055W OLE1
SGTC_999 SEC7.066 22.7 µM -0.652064503820365 0.280647687069498 no 2420 0.257179780792224 3598 740511 YDR170C SEC7
SGTC_608 k048-0125 159 µM -0.652910733757702 0.280348770741637 no 2421 0.256906914331803 3629 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1665 st014639 11.4 µM -0.654045145042582 0.279948301284127 no 2422 0.256541360397621 3663 981133 YIL048W NEO1
SGTC_3087 9117406 49.47 µM -0.655359529298931 0.279484644995786 no 2423 0.256118150850628 3597 42546093
SGTC_955 1216-0110 33 µM -0.656321604778942 0.279145504112955 no 2424 0.255808609734802 3571 3619719
SGTC_3296 9122258 64.045 µM -0.656393412925468 0.279120199074752 no 2425 0.255785513795646 3606 4730474
SGTC_1429 4049-0205 9.46 µM -0.65755412508652 0.278711321363832 no 2426 0.255412340393783 3642 22774478
SGTC_949 1165-0505 146 µM -0.65871749363011 0.278301800718188 no 2427 0.255038598641939 3616 6244267
SGTC_1767 st044992 70.3 µM -0.659732388618352 0.277944784397242 no 2428 0.254712789059654 3574 9600693
SGTC_366 0181-0206 4.31 µM -0.659933202591685 0.277874169236064 no 2429 0.254648348014289 3631 274874
SGTC_1018 4259-0013 28.1 µM -0.660330694337616 0.277734419215979 no 2430 0.254520818408831 3604 6801262
SGTC_1010 4112-3296 15.2 µM -0.660982683697887 0.277505267357736 no 2431 0.254311709320479 3647 704384
SGTC_1711 st032263 62.8 µM -0.661380191608745 0.277365602341968 no 2432 0.254184262924593 3610 3958979
SGTC_1776 st049249 45.9 µM -0.661536512318696 0.277310688237065 no 2433 0.254134153574441 3605 1822314
SGTC_2458 5808907 16.39 µM -0.662228966270125 0.277067499150636 no 2434 0.253912246476842 3672 2731747
SGTC_1778 st046819 58.9 µM -0.662892338168493 0.27683462158538 no 2435 0.253699754567666 3648 671715
SGTC_3171 9103192 49.47 µM -0.663151784920985 0.276743568552704 no 2436 0.25361667375115 3650 13018434
SGTC_184 1494-0393 24.714 µM -0.663552985520772 0.276602795794249 no 2437 0.253488228234354 3608 3090647
SGTC_2103 5378138 10 µM -0.664918454941751 0.276123944785661 no 2438 0.253051325574471 3663 244142
SGTC_757 1066-0008 322 µM -0.665497850672351 0.275920881857793 no 2439 0.252866058907114 3620 6842497
SGTC_1319 1306-0155 43.7 µM -0.667102776681483 0.275358780914399 no 2440 0.2523532433271 3651 3122360
SGTC_2075 5212009 200 µM -0.66815448278358 0.274990742704237 no 2441 0.252017493462789 3555 780898
SGTC_902 1120-0002 2.07 µM -0.668444246965239 0.274889384076443 no 2442 0.251925029694852 3623 3280475
SGTC_2823 7987624 58.44 µM -0.669768579908305 0.274426370953675 no 2443 0.251502662991227 3661 2239440
SGTC_3058 9093861 49.47 µM -0.670515830403845 0.274165287298484 no 2444 0.251264509203782 3644 17217477
SGTC_1185 1319-0113 81.3 µM -0.670589920564359 0.274139407445534 no 2445 0.251240902667751 3637 4672763
SGTC_2610 ononetin 44.17 µM -0.670973209832479 0.274005542950345 no 2446 0.251118798137567 3631 259632
SGTC_34 0469-0683 81.75 µM -0.67133213964788 0.273880215336854 no 2447 0.25100448227097 3620 3690923
SGTC_3250 9135583 49.47 µM -0.671847505649451 0.273700314435918 no 2448 0.25084039107493 3642 7699353
SGTC_70 0141-0289 43.283 µM -0.672182438730026 0.27358342933484 no 2449 0.25073377970613 3674 352408
SGTC_1259 0671-0132 43 µM -0.672749993745983 0.2733854201338 no 2450 0.250553178062384 3576 X1259
SGTC_50 0929-0078 56.389 µM -0.674940648131983 0.272621808492087 no 2451 0.249856736990264 3549 1377751
SGTC_2362 9071156 126 µM -0.675380202193964 0.272468717694484 no 2452 0.249717120210771 3638 653133
SGTC_554 4483-2211 187 µM -0.676553791505023 0.272060181514616 no 2453 0.249344552846862 3632 747107
SGTC_2756 carbadox 75.1 µM -0.67700002180896 0.271904925002393 no 2454 0.249202970264625 3649 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1886 st057356 49.9 µM -0.677217178617727 0.27182938577434 no 2455 0.249134084940616 3604 24207747
SGTC_2087 5276107 200 µM -0.679699132392582 0.270966766489999 no 2456 0.248347492747325 3629 144405
SGTC_3336 9143619 71.43 µM -0.679704492967421 0.270964904866229 no 2457 0.248345795283269 3669 45595730
SGTC_1857 st056007 79.3 µM -0.679841961393939 0.270917166925595 no 2458 0.24830226704376 3655 619834
SGTC_1943 st076331 65.2 µM -0.68001494104394 0.270857103151868 no 2459 0.248247500249055 3697 24208415
SGTC_2329 6138490 200 µM -0.681434422494145 0.270364467380461 no 2460 0.247798324028766 3636 720019
SGTC_2029 5175081 200 µM -0.682243354389302 0.270083925348263 no 2461 0.247542542405367 3652 1380876
SGTC_1097 itavastatin 7.23 µM -0.683870671080585 0.269520004489941 no 2462 0.247028417777738 3674 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3209 9113616 49.47 µM -0.685225759533589 0.269050870713518 no 2463 0.246600735616084 3676 16649353
SGTC_1092 toremifene 6.32 µM -0.685645429969896 0.268905663301665 no 2464 0.246468363076978 3656 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1409 3909-8004 61.9 µM -0.686394572986446 0.26864655509665 no 2465 0.24623216290265 3666 2119279
SGTC_516 3992-2719 87.3 µM -0.686832220712849 0.268495242721167 no 2466 0.246094231456684 3624 5350887 YDR037W KRS1
SGTC_3011 9081274 71.4286 µM -0.687550672175137 0.268246938165238 no 2467 0.245867890264122 3653 6625322
SGTC_2420 aureobasidin a 50 nM -0.687769282513272 0.268171407011895 no 2468 0.245799041366714 3715 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_74 000s-0487 160.283 µM -0.687906455279037 0.268124018482512 no 2469 0.245755845613086 3611 677548
SGTC_1705 st027868 56.3335 µM -0.689234221259001 0.267665538404845 no 2470 0.245337942354314 3670 292948
SGTC_3076 9116187 49.47 µM -0.691868034080836 0.266757248722644 no 2471 0.244510103344344 3615 27241210
SGTC_1949 st076024 69.1 µM -0.692182192022226 0.266649013126184 no 2472 0.244411460278097 3649 2921930
SGTC_2544 sphondin 68.51 µM -0.693543381477089 0.266180304543438 no 2473 0.243984305595618 3682 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1932 st074806 40.9 µM -0.694954807217742 0.265694738609355 no 2474 0.243541811926455 3763 17251235
SGTC_2836 9010338 19.48 µM -0.695658458363115 0.265452832798928 no 2475 0.243321373480215 3594 2994051
SGTC_571 k831-0106 44.2 µM -0.695894982447868 0.265371544099136 no 2476 0.243247299903121 3637 4783639
SGTC_1285 0929-0069 65.5 µM -0.696983532237108 0.264997593776105 no 2477 0.242906549844517 3682 1206237
SGTC_2833 9001315 45.46 µM -0.697635411914573 0.264773781311448 no 2478 0.242702614866279 3671 2989378
SGTC_2047 4141938 200 µM -0.698083290501184 0.264620065078948 no 2479 0.242562553618773 3656 3807862
SGTC_1634 st006576 41 µM -0.698211036372893 0.264576229790587 no 2480 0.242522612767214 3656 3915356
SGTC_842 0271-0008 11.1 µM -0.698399307208199 0.26451163243109 no 2481 0.242463754756282 3726 1221709
SGTC_2360 9040895 200 µM -0.700411848634145 0.263821613750858 no 2482 0.241835069406465 3649 4914414
SGTC_6 0844-0013 19.835 µM -0.702784869396402 0.263009182124655 no 2483 0.241094913961621 3776 1584900
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.703999672364537 0.262593775440229 no 2484 0.240716488823044 3725 1377
SGTC_2390 9097792 176.6 µM -0.704553303295641 0.262404570592788 no 2485 0.240544133694324 3682 4497149
SGTC_3057 9095946 49.47 µM -0.705327953921753 0.262139948893237 no 2486 0.240303084043575 3702 24540043
SGTC_1422 4031-0024 15.5 µM -0.706181721878665 0.261848459101308 no 2487 0.240037567818664 3645 782427
SGTC_121 0557-0495 61.343 µM -0.707309023800934 0.261463835339667 no 2488 0.239687229502043 3806 3104427
SGTC_125 0133-0007 11.75 µM -0.708373212577623 0.261101011501107 no 2489 0.239356761448109 3769 26541
SGTC_2968 9090663 33.37 µM -0.709418277985639 0.260744959602655 no 2490 0.239032474226623 3687 25236811
SGTC_594 1487-1584 10.8 µM -0.710270978011809 0.26045463143987 no 2491 0.238768056653413 3673 5013332
SGTC_636 0kpi-0074 126 µM -0.710451208329713 0.260393287759756 no 2492 0.238712188718431 3707 616434
SGTC_2892 9047358 58.44 µM -0.711819688219102 0.259927751130709 no 2493 0.238288219672226 3687 6466771
SGTC_1492 4158-0558 28.5 µM -0.712225155797199 0.259789899541552 no 2494 0.238162680930031 3698 3967268
SGTC_53 0973-0023 39.979 µM -0.712926849788628 0.259551425533069 no 2495 0.237945511772825 3658 674768
SGTC_2086 5274770 176.623 µM -0.713285990839686 0.259429413501849 no 2496 0.237834402262772 3726 689278
SGTC_1571 st070080 73.4 µM -0.713450613143239 0.259373495793402 no 2497 0.237783481636146 3756 4315245
SGTC_282 k297-0036 65.7 µM -0.713657483632594 0.25930323635785 no 2498 0.23771950136848 3703 5061378
SGTC_3187 9109394 49.47 µM -0.713878945086325 0.259228032293171 no 2499 0.237651018920099 3651 17098090
SGTC_1130 3454-2858 15.9 µM -0.714367317687746 0.259062230167927 no 2500 0.237500037893002 3716 715628 YIL048W NEO1
SGTC_324 1315-0088 19.6 µM -0.714836441561259 0.258903014624087 no 2501 0.237355057227042 3636 6787421
SGTC_3134 9127454 49.47 µM -0.718636629248111 0.257615140677854 no 2502 0.236182419122982 3782 24262820
SGTC_2475 5812728 15.03 µM -0.719043288686555 0.257477522133869 no 2503 0.236057123980413 3694 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1468 k284-1086 134 µM -0.719250493908226 0.257407416034262 no 2504 0.235993296421722 3712 15996457
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.722471291934456 0.256318963433103 no 2505 0.235002384662941 3728 165521
SGTC_1625 st003711 30.1 µM -0.724024720696121 0.255794848796607 no 2506 0.234525279253497 3745 24207034 YER133W GLC7
SGTC_2430 5571206 200 µM -0.725624222964566 0.2552557744702 no 2507 0.234034583673098 3747 1731771
SGTC_2068 5226020 147 µM -0.725838670308707 0.255183545256846 no 2508 0.233968838738619 3760 1810509
SGTC_2484 5809818 12.04 µM -0.727147678058911 0.254742882851536 no 2509 0.233567747089099 3721 2870548
SGTC_1970 st070122 35.8 µM -0.728318651383238 0.254349026029228 no 2510 0.233209273766439 3729 102928
SGTC_2850 9015429 58.44 µM -0.72870515514522 0.25421909560678 no 2511 0.233091019362568 3766 6457570
SGTC_2908 7930301 100 µM -0.729684982723785 0.253889864374716 no 2512 0.232791381284558 3728 2223178
SGTC_1628 st004252 77.7 µM -0.729704919742953 0.253883167673611 no 2513 0.232785286628268 3716 692968
SGTC_1278 0874-0585 172 µM -0.729753193424054 0.253866953275923 no 2514 0.232770529950268 3778 766306
SGTC_2502 avocadyne acetate 18.59 µM -0.732938358338525 0.252798306918805 no 2515 0.231798013205734 3701 3952079
SGTC_675 1309-0189 238 µM -0.734832098599049 0.252164067532096 no 2516 0.231220877887209 3751 4246530
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.734978986924765 0.252114907729474 no 2517 0.231176145803655 3763 115019
SGTC_1197 1601-0112 267 µM -0.735560892547695 0.25192020834844 no 2518 0.230998984826829 3732 7350313
SGTC_1102 cgs 12066b 26.1 µM -0.73585540627087 0.251821697469756 no 2519 0.230909349113682 3738 6438352 A 5-HT1B full agonist.
SGTC_756 0508-1999 28.3 µM -0.736143731213327 0.251725276358874 no 2520 0.230821615781369 3725 6753853
SGTC_2975 9084847 53.72 µM -0.737786637889674 0.251176230711575 no 2521 0.230322057190896 3791 27211724
SGTC_1345 1488-0192 31.4 µM -0.738473445593687 0.250946893204094 no 2522 0.230113398924485 3745 658348
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.738738208585077 0.250858513659128 no 2523 0.230032989834023 3667 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_925 2064-1272 59.6 µM -0.739037643838038 0.250758580154269 no 2524 0.229942069652839 3740 6815817
SGTC_720 r052-1644 49.9 µM -0.739039213966869 0.250758056195122 no 2525 0.229941592953717 3726 1422863 YOR257W CDC31
SGTC_177 1327-0068 8.361 µM -0.740186579940381 0.250375329983669 no 2526 0.229593394718259 3742 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_532 1548-0774 215 µM -0.741119116521467 0.250064492544739 no 2527 0.229310609826329 3826 5932993
SGTC_1181 1222-0449 220 µM -0.741739666527965 0.249857761430044 no 2528 0.229122540833186 3772 658318
SGTC_2349 9023730 187.07 µM -0.741754003505508 0.249852986256747 no 2529 0.229118196773488 3721 4126287
SGTC_1618 st003135 44.5 µM -0.742409530689873 0.249634703578029 no 2530 0.2289196234226 3667 1270615
SGTC_3077 9117319 49.47 µM -0.742529558183967 0.249594746838645 no 2531 0.228883274964377 3721 17154678
SGTC_1048 3161-0300 24.5 µM -0.743920775258777 0.249131863484843 no 2532 0.22846220296335 3743 2165101
SGTC_82 0054-0107 293.755 µM -0.744507190152408 0.248936889415858 no 2533 0.228284846471898 3735 3104697
SGTC_3111 9122088 49.47 µM -0.744849955243363 0.248822962832724 no 2534 0.228181215761033 3647 16876704
SGTC_2305 7443522 69.23 µM -0.74549257238404 0.248609447716646 no 2535 0.227986999852032 3699 5415886
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.747803991420439 0.247842266260291 no 2536 0.22728919711143 3767 521171
SGTC_1387 3342-1166 1.8 µM -0.748169836123657 0.247720954952248 no 2537 0.227178861339565 3762 3418228
SGTC_2404 5161160 200 µM -0.748607910306486 0.247575734626934 no 2538 0.227046781475064 3715 2831543
SGTC_1365 1672-3266 55.4 µM -0.749271420137673 0.247355869669961 no 2539 0.226846814981868 3751 6415873
SGTC_1287 0971-0001 34.6 µM -0.749276803866896 0.247354086109204 no 2540 0.226845192857031 3735 4665869
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.749900579461216 0.247147483766385 no 2541 0.226657292738815 3784 368090
SGTC_1228 0124-0032 52.5 µM -0.750029974745902 0.247104637977797 no 2542 0.226618325960321 3814 X1228
SGTC_1056 3448-1962 115 µM -0.750354280330507 0.246997270315395 no 2543 0.226520679482776 3772 715507
SGTC_543 3844-1095 191 µM -0.750928881942642 0.246807098601603 no 2544 0.22634772870693 3769 4230703
SGTC_1836 st055642 81 µM -0.751660902547194 0.246564940652559 no 2545 0.226127504068015 3783 8571
SGTC_2153 5569715 200 µM -0.752120797022421 0.246412869209538 no 2546 0.225989209135126 3762 2054701
SGTC_298 1391-0729 10 µM -0.752239428448697 0.246373649993289 no 2547 0.225953543221437 3720 3237558
SGTC_2385 9074692 200 µM -0.752411526748614 0.246316760726614 no 2548 0.225901808431285 3764 17046906
SGTC_234 nsc-17383 10.7 µM -0.753788197904277 0.245861938260728 no 2549 0.225488205922315 3769 408974
SGTC_3222 9128301 49.47 µM -0.756918852284972 0.244829317843701 no 2550 0.224549240038124 3797 4911358
SGTC_1044 1222-0021 1.78 µM -0.757392435755751 0.244673313782486 no 2551 0.224407393279551 3780 4306703
SGTC_1710 st031758 61.5 µM -0.757427202972776 0.244661863154638 no 2552 0.22439698187754 3795 5394341
SGTC_1398 3558-0053 112 µM -0.757827672879389 0.244529988681198 no 2553 0.224277076798623 3678 4532369
SGTC_812 4251-0442 148 µM -0.759272063744649 0.244054669998793 no 2554 0.22384491266991 3746 5723007
SGTC_1195 1502-0147 41.1 µM -0.760572863566495 0.243627030970973 no 2555 0.223456116600319 3761 817940
SGTC_634 1611-4317 11.2 µM -0.761012074667248 0.243482731384766 no 2556 0.223324927599511 3777 2843522
SGTC_2826 7992541 19.48 µM -0.761150734321232 0.243437185363146 no 2557 0.223283520124829 3832 2985066
SGTC_1135 dihydrocapsaicin 536.708 nM -0.762906995948981 0.242860698545615 no 2558 0.22275943183032 3704 107982 A Capsaicinoid.
SGTC_1395 3486-0190 4.35 µM -0.764136678072111 0.242457499745577 no 2559 0.222392898440691 3774 6748079
SGTC_2595 hexamethylquercetagetin 100 µM -0.76466489745688 0.242284414010898 no 2560 0.222235556897216 3746 386331
SGTC_91 0417-1751 58.384 µM -0.765638599370224 0.241965529141185 no 2561 0.221945685297778 3874 6795624
SGTC_1061 3448-9325 110 µM -0.766443754910076 0.241702014827887 no 2562 0.221706153209284 3712 723482
SGTC_2980 9014342 25.29 µM -0.768177264454345 0.241135194475201 no 2563 0.22119093940057 3839 2996599
SGTC_1677 st019204 53.9 µM -0.768224644159333 0.241119712482054 no 2564 0.221176867371323 3814 3945625
SGTC_2800 7887935 81.82 µM -0.769508910802204 0.240700265989561 no 2565 0.220795628359362 3791 2961002
SGTC_2900 5328528 85.29 µM -0.771539673960489 0.240037822086191 no 2566 0.220193557890821 3804 795359
SGTC_1623 st003709 20.3 µM -0.771590329077413 0.240021310879847 no 2567 0.22017855196104 3778 16192618
SGTC_2778 tioconazole 65.09 nM -0.772004333066478 0.239886388098157 no 2568 0.220055930566763 3734 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.77452536865395 0.239065683048124 no 2569 0.219310086062588 3765 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3169 9102970 49.47 µM -0.77496563056122 0.238922516530398 no 2570 0.219179984426298 3862 17027839
SGTC_932 2857-0803 154 µM -0.775773252780295 0.23866001192259 no 2571 0.218941439665516 3898 674898
SGTC_2115 tiliquinol 12.7705 µM -0.778664260697424 0.237721631279834 no 2572 0.218088757123681 3799 71208 A bioactive hydroxyquinoline.
SGTC_1046 2001-0062 216 µM -0.778922169317187 0.237638016206165 no 2573 0.218012781893761 3715 739778
SGTC_428 3448-4153 16.5 µM -0.779331566975436 0.237505320886246 no 2574 0.217892212064748 3780 3834874
SGTC_106 0092-0003 11.579 µM -0.780351672215925 0.237174858004724 no 2575 0.217591952879683 3757 1072148
SGTC_2694 st077685 81.9 µM -0.781333816948078 0.236856931244579 no 2576 0.217303092794142 3788 2838096
SGTC_2537 larixol 68.93 µM -0.782668012261642 0.236425418996932 no 2577 0.216911045551103 3803 6708759
SGTC_3189 9110682 49.47 µM -0.7838913612435 0.236030137830159 no 2578 0.216551929588167 3890 17122418
SGTC_3038 9091290 49.47 µM -0.784025273589988 0.235986891001282 no 2579 0.216512640312415 3808 25236843
SGTC_1817 st052116 64.4 µM -0.785062290888618 0.235652135415919 no 2580 0.216208523808075 3791 4361398
SGTC_1696 st025591 34.7925 µM -0.785332974961596 0.235564800051067 no 2581 0.216129183510738 3810 2787147
SGTC_2791 5663188 71.43 µM -0.785663503884399 0.235458180152825 no 2582 0.216032324939051 3788 54690634
SGTC_1986 st071812 45 µM -0.786369389577665 0.235230569268185 no 2583 0.21582555560402 3751 11838594
SGTC_307 1501-1223 22.3 µM -0.787365041314212 0.234909730763232 no 2584 0.215534102539833 3818 2830329
SGTC_1013 4112-3890 241 µM -0.787806176989439 0.234767656687103 no 2585 0.21540504370304 3777 705171
SGTC_2713 st079149 53.4 µM -0.788725907833523 0.234471596989573 no 2586 0.215136111088917 3849 3103253
SGTC_3206 9114350 49.47 µM -0.788865398713121 0.23442671317388 no 2587 0.215095340482326 3747 17087243
SGTC_2715 st079500 56.4 µM -0.789562844475385 0.234202368198588 no 2588 0.214891557269868 3760 28246688
SGTC_143 4032-1194 15.74 µM -0.789651623873168 0.234173819366333 no 2589 0.214865625307123 3839 1806963
SGTC_760 0568-0725 82.9 µM -0.790749727413944 0.233820861054767 no 2590 0.214545025765289 3859 3916171
SGTC_1337 1486-1011 40.3 µM -0.7924256513654 0.233282745420973 no 2591 0.214056263701916 3822 X1337
SGTC_1473 k844-0725 134 µM -0.793119121708147 0.233060283026076 no 2592 0.213854211537214 3883 54682906
SGTC_1152 3909-8331 15.9 µM -0.793255923699599 0.233016411432984 no 2593 0.21381436550605 3792 16001939
SGTC_2040 5100729 123 µM -0.794970488980861 0.232466949559324 no 2594 0.213315334427008 3832 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1122 capsaicin 818.572 nM -0.796027285045637 0.232128640372928 no 2595 0.213008088270335 3925 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2093 5331342 194.4 µM -0.796822983110636 0.231874096715784 no 2596 0.212776922572827 3860 33839
SGTC_1518 st038567 90.8 µM -0.797023580554248 0.231809950177772 no 2597 0.212718668253609 3807 77966
SGTC_1570 verbenone 133 µM -0.797982441177425 0.231503464778774 no 2598 0.212440339869211 3847 29025 A natural terpanoid with antifungal properties.
SGTC_1736 st036774 51 µM -0.798767628245716 0.231252659853575 no 2599 0.212212582224366 3924 1272247
SGTC_2062 5245942 200 µM -0.798908826361049 0.231207574352068 no 2600 0.21217164031623 3894 1376160
SGTC_3130 9127414 49.47 µM -0.798910559186957 0.231207021079643 no 2601 0.212171137893455 3825 1494646
SGTC_1502 4534-4282 27.7 µM -0.800021511218951 0.230852458289207 no 2602 0.211849167018597 3810 3278949
SGTC_83 0170-0301 39.027 µM -0.800316741866727 0.23075828586913 no 2603 0.211763652766122 3760 3089716
SGTC_382 3229-0966 23.2 µM -0.800949550952992 0.230556505274169 no 2604 0.21158042618807 3838 5722370
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.802059094124411 0.230202949051653 no 2605 0.211259387862199 3837 688761
SGTC_2703 st077852 53.4 µM -0.803949541703941 0.229601256567675 no 2606 0.210713058325257 3841 6281836
SGTC_3089 9117425 49.47 µM -0.80496567146914 0.229278206742458 no 2607 0.210419744892728 3801 9401657
SGTC_1439 4092-1168 46 µM -0.805220401677407 0.229197262419548 no 2608 0.210346252709836 3840 2886240
SGTC_2014 4013930 200 µM -0.805303651976449 0.22917081187029 no 2609 0.21032223744359 3795 64556
SGTC_2020 4017018 200 µM -0.806014537364863 0.228945016844437 no 2610 0.21011723346431 3928 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2843 9000894 45.46 µM -0.807712465684164 0.228406217725195 no 2611 0.209628062904842 3764 2242070
SGTC_3234 9132280 49.47 µM -0.808389522919056 0.228191567803237 no 2612 0.209433190683862 3878 17612295
SGTC_1550 gossypolone 36.6 µM -0.808883842558153 0.228034923501041 no 2613 0.209290981774153 3841 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_470 aa-861 153 µM -0.810159520493202 0.227630955150591 no 2614 0.208924249605098 3850 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2676 harmalol 100 µM -0.810577650591886 0.227498633809193 no 2615 0.208804127896507 3811 5459187 A monoamine oxidase inhibitor
SGTC_2477 5967686 25.23 µM -0.811398384982457 0.22723903042983 no 2616 0.208568463154011 3850 776118
SGTC_3148 9097893 49.47 µM -0.813350316648938 0.22662229349806 no 2617 0.208008618059055 3861 17174100
SGTC_1917 st066507 28.5 µM -0.813567318250861 0.226553787564107 no 2618 0.207946433384603 3827 3156428
SGTC_2180 6301957 200 µM -0.813782960840677 0.226485722243744 no 2619 0.207884649027556 3802 845462
SGTC_3275 9138069 49.47 µM -0.813831009920385 0.226470557629139 no 2620 0.207870883829258 3949 17617007
SGTC_441 propafenone 146 µM -0.813864395701804 0.226460021188255 no 2621 0.207861319719474 3820 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_879 0831-1030 162 µM -0.814125812848253 0.226377528381653 no 2622 0.207786439868298 3892 1549252
SGTC_1258 0671-0043 57.1 µM -0.814639414786986 0.226215505567669 no 2623 0.207639371073459 3890 4298767
SGTC_1054 3429-0080 167 µM -0.817932839716342 0.225178107751397 no 2624 0.206697768669063 3866 1162877
SGTC_1803 st050068 52.4 µM -0.81931618431826 0.224743172245379 no 2625 0.206303020559117 3917 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3081 9117243 49.47 µM -0.81934974419538 0.224732626652109 no 2626 0.206293449542459 3891 45595589
SGTC_7 0192-1582 4.227 µM -0.822613569757923 0.223708369256263 no 2627 0.205363889730739 3908 252616
SGTC_1829 berberine 14.4 µM -0.823100917993756 0.223555657152994 no 2628 0.205225303411851 3892 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2727 riluzole 51.77 µM -0.827336382384307 0.222230960420451 no 2629 0.204023213908325 3871 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1005 4092-0690 4.4 µM -0.82841129916262 0.221895480198296 no 2630 0.203718804837196 3907 1529343
SGTC_1929 genistein trimethyl ether 50.5 µM -0.829753458089591 0.221477000331849 no 2631 0.203339094996459 3817 136420
SGTC_2070 5230947 200 µM -0.832079187060673 0.22075291655275 no 2632 0.202682124419015 3931 2835538
SGTC_673 1082-0474 110 µM -0.83236174463643 0.220665038586006 no 2633 0.202602394225655 3888 3098046
SGTC_209 4077-0173 175.592 µM -0.83237366445086 0.220661331856248 no 2634 0.202599031184862 3837 15993494
SGTC_791 1348-1292 225 µM -0.83276267160683 0.220540381060336 no 2635 0.202489295530998 3851 5437054
SGTC_1750 st081859 2.357 µM -0.832883364883837 0.22050286261501 no 2636 0.202455256194786 3850 5291695
SGTC_2749 bexarotene 57.39 µM -0.832983292322523 0.220471802160205 no 2637 0.202427076073479 3921 82146 An retinoic acid receptor inhibitor.
SGTC_1491 4138-0063 26.5 µM -0.834100851384237 0.220124602045236 no 2638 0.20211207771272 3820 23883227
SGTC_1038 k292-0204 154 µM -0.834524203696662 0.219993158084409 no 2639 0.20199282707351 3836 4454212
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.834690815842271 0.219941440093135 no 2640 0.201945907016039 3914 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1477 0139-0234 16 µM -0.83515808651037 0.219796432069934 no 2641 0.201814352580649 3895 620880
SGTC_859 0439-0102 54.6 µM -0.835707098210675 0.21962612750735 no 2642 0.201659850523964 3853 610143
SGTC_892 0929-0076 29 µM -0.836032435488859 0.219525242980438 no 2643 0.201568328032069 3869 5751038
SGTC_1444 4112-3581 28 µM -0.837913052046702 0.218942600508016 no 2644 0.201039768895527 3913 2877249
SGTC_1481 3346-2004 36 µM -0.840203093612703 0.218234314716773 no 2645 0.200397262079828 3918 2770522
SGTC_2831 7999036 19.48 µM -0.840209041495143 0.218232476819932 no 2646 0.200395594916439 3964 2988270
SGTC_145 3737-0113 38.366 µM -0.842327175799924 0.217578540233982 no 2647 0.19980242177482 3876 6849351
SGTC_878 0828-0289 13.7 µM -0.842572919103012 0.217502744608259 no 2648 0.199733671005088 3861 745350 YLR208W SEC13
SGTC_22 0964-0034 14.468 µM -0.842589906332338 0.217497505729953 no 2649 0.199728919071559 3927 138402
SGTC_2809 7964133 12.99 µM -0.842817908242749 0.217427196765649 no 2650 0.19966514539345 3915 1253665
SGTC_2400 5203494 178.7 µM -0.842921347770055 0.217395303439157 no 2651 0.199636216697947 3819 6777674
SGTC_3285 9112818 20.8695 µM -0.843087653346181 0.217344032397883 no 2652 0.199589711686091 3884 17017947 YPR165W RHO1
SGTC_847 0342-0274 5.54 µM -0.845914613786039 0.216473565690463 no 2653 0.19880018972252 3897 18097
SGTC_1160 4092-0570 10.5 µM -0.846886809189033 0.216174677865453 no 2654 0.198529107768216 3886 4994975
SGTC_1973 st070275 50.2 µM -0.847384135389492 0.216021874345224 no 2655 0.198390522144078 3794 17118334
SGTC_797 k781-0471 270 µM -0.848057425639958 0.215815105579267 no 2656 0.198202995166431 3877 23738129
SGTC_1638 st008370 60.6 µM -0.849373906296075 0.215411143347566 no 2657 0.19783663401802 3866 24207134
SGTC_2723 salbutamol 83.58 µM -0.850005198984891 0.215217586832635 no 2658 0.197661097886663 3904 9884233 β2-adrenoceptor agonist
SGTC_309 k408-0051 1.48 µM -0.850673345576327 0.215012840780831 no 2659 0.197475416798871 3860 3640463
SGTC_458 nppb 133 µM -0.85082538444156 0.214966265973108 no 2660 0.197433179216341 3901 4549 A chloride channel blocker.
SGTC_3036 9090181 49.47 µM -0.852222586068986 0.214538528786163 no 2661 0.197045281544136 3925 25236586
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.853295099723605 0.214210527019118 no 2662 0.19674783842398 3927 551469
SGTC_2877 9040724 71.43 µM -0.853669462014968 0.214096106302301 no 2663 0.196644079571005 3853 6463895
SGTC_1298 1079-1278 263 µM -0.855245151068943 0.213614900135716 no 2664 0.19620772255833 3924 2840950
SGTC_2321 7390090 138.78 µM -0.855364046367698 0.213578615796967 no 2665 0.19617482061408 3944 649046
SGTC_3183 9108214 49.47 µM -0.85709390773401 0.213051104931471 no 2666 0.195696493923495 3856 4974831
SGTC_431 k089-0097 107 µM -0.857633603832428 0.212886683532691 no 2667 0.195547406725063 3800 5499420
SGTC_742 0kpi-0133 140 µM -0.858191201915224 0.212716886003699 no 2668 0.195393446692641 3978 2728852
SGTC_448 monastrol 171 µM -0.858899870800665 0.212501199150464 no 2669 0.195197880355275 3831 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1993 st073995 70.8 µM -0.859121696237308 0.212433711752612 no 2670 0.19513668921243 3901 3098394
SGTC_1507 4075-3230 155 µM -0.862901301340714 0.211285743599288 no 2671 0.194095867565364 3804 659771
SGTC_2981 9013952 38.96 µM -0.862918178620425 0.211280625677407 no 2672 0.194091227524474 3895 2996344
SGTC_729 4092-0585 94.1 µM -0.862951157744903 0.211270625188708 no 2673 0.194082160826699 3931 2169061
SGTC_1745 st081495 74 µM -0.863174922621362 0.211202778737445 no 2674 0.194020649680185 3837 13842402 YBL026W LSM2
SGTC_1229 0139-0193 12.2 µM -0.863759854818333 0.211025485152641 no 2675 0.193859912688793 3962 3090752
SGTC_509 pifithrin 175 µM -0.866013679540575 0.210343164631612 no 2676 0.193241330057731 3961 4817 A p53 inhibitor.
SGTC_3045 9092950 49.47 µM -0.8663494395226 0.210241627982345 no 2677 0.193149280897555 3874 44120432
SGTC_2091 4-phenylthiadiazole 200 µM -0.869924678223725 0.209162231986638 no 2678 0.192170784033926 3903 270010
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.87003953062704 0.209127611212662 no 2679 0.192139400765751 4011 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_903 1134-0042 114 µM -0.870633231149482 0.208948701664609 no 2680 0.191977222882669 3944 701009
SGTC_46 0329-0187a 2.197 µM -0.872148034890466 0.208492629607659 no 2681 0.19156381207438 4005 46494817
SGTC_2232 chlorophetanol 41.5365 µM -0.87258901295025 0.208359971800843 no 2682 0.191443565650771 3991 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3294 9122953 26.2835 µM -0.872841829596273 0.208283940358878 no 2683 0.191374648169203 3934 16459826
SGTC_3254 9136651 49.47 µM -0.874285146468616 0.207850194430844 no 2684 0.190981493148093 3920 16454030
SGTC_2291 7917025 104.35 µM -0.874647283045833 0.207741448829838 no 2685 0.190882926070132 3876 2964612
SGTC_3334 9142812 21.919 µM -0.875013176151944 0.207631609324878 no 2686 0.190783368235179 3971 45283678
SGTC_1952 st077036 64.1 µM -0.877655320936475 0.206839468141175 no 2687 0.19006539892374 3937 2937007
SGTC_695 3505-6186 243 µM -0.879855271543555 0.206181268064319 no 2688 0.189468858997612 3953 1819379
SGTC_3249 9135183 49.47 µM -0.881529229296466 0.205681271926473 no 2689 0.189015720399791 3961 4902779
SGTC_197 4544-0043 41.561 µM -0.881739753335829 0.205618441271841 no 2690 0.188958779059166 3933 896523
SGTC_4 0960-0234 25.671 µM -0.88182560240431 0.205592822987873 no 2691 0.18893556212675 3938 6821112
SGTC_1934 st074720 32.6 µM -0.882542866574801 0.205378857715395 no 2692 0.188741654642188 3895 17250992
SGTC_342 k048-0088 23.3 µM -0.883224917860773 0.205175519437414 no 2693 0.188557380540294 3944 6820570
SGTC_646 4092-0839 27.3 µM -0.883324856484646 0.205145735032 no 2694 0.188530388812533 3996 877796
SGTC_978 1416-0512 87.4 µM -0.884848438526113 0.204691984733069 no 2695 0.188119190219241 4007 6814003
SGTC_2327 6189656 200 µM -0.885537616540821 0.204486931313035 no 2696 0.187933370357544 4040 5349088
SGTC_2481 5478948 45.16 µM -0.885611912166785 0.204464833191434 no 2697 0.18791334514283 4010 77792
SGTC_2472 5377652 49.4 µM -0.885650253362307 0.204453429732896 no 2698 0.187903011393439 4031 1610903
SGTC_2213 7173844 200 µM -0.887023103083667 0.204045365533815 no 2699 0.187533231094216 3909 892728
SGTC_3004 9076122 71.4286 µM -0.887798530242263 0.203815093082534 no 2700 0.1873245668376 3993 44782551
SGTC_700 3453-2283 142 µM -0.888254418503919 0.203679783896742 no 2701 0.18720195621126 4014 565664
SGTC_2832 7992762 51.95 µM -0.888456236609503 0.203619900704656 no 2702 0.187147693314266 3921 2985177
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.889021738428336 0.203452161713469 no 2703 0.186995698488097 4009 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.889743829396547 0.203238095166748 no 2704 0.186801726895233 3968 616764
SGTC_260 nsc-65238 3.989 µM -0.890856380843094 0.202908538409324 no 2705 0.186503111758975 3937 3246252
SGTC_1908 st060353 56.5 µM -0.895093350917065 0.201656400967511 no 2706 0.185368594011778 4018 4227716
SGTC_1064 honokiol 6.76 µM -0.895343494279623 0.201582621922949 no 2707 0.185301748266352 3968 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1675 st018485 24.5 µM -0.895595278197029 0.201508375334933 no 2708 0.18523447923285 4024 3323024
SGTC_3079 9117512 49.47 µM -0.897215367256638 0.201031032003075 no 2709 0.184802003335657 3979 7185044
SGTC_2988 9073640 71.4286 µM -0.899151111049461 0.200461574364444 no 2710 0.184286088455089 4031 9102229
SGTC_3261 9137475 49.47 µM -0.899488301901562 0.200362478641741 no 2711 0.184196312013712 3869 17027690
SGTC_131 0141-0277 33.849 µM -0.900848078932835 0.19996315772464 no 2712 0.183834550177476 3955 1547771
SGTC_947 3447-0010 211 µM -0.900986441055601 0.199922552249706 no 2713 0.183797764453361 3925 748350
SGTC_2031 5180455 200 µM -0.901090429100967 0.199892037884332 no 2714 0.183770120631004 3922 29949
SGTC_744 1594-0068 283 µM -0.901172208561421 0.199868042397947 no 2715 0.183748382481531 3970 668392
SGTC_1624 st003710 6.25 µM -0.904705565938555 0.198832950310929 no 2716 0.18281069581413 4013 24207033
SGTC_21 0849-0113 22.993 µM -0.904760705785062 0.198816822820429 no 2717 0.182796086444693 3926 1560156
SGTC_898 1000-0849 28.3 µM -0.905138805816662 0.198706256077457 no 2718 0.182695928014932 3969 6751807
SGTC_2575 plumbagin 510 nM -0.90602069816711 0.19844851087878 no 2719 0.182462448553352 3888 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1579 chlormadinone acetate 49.4 µM -0.906458443477154 0.198320648721886 no 2720 0.18234662549786 4014 45114258 A steroidal progestin.
SGTC_1196 1588-0294 184 µM -0.906489643000123 0.198311537471219 no 2721 0.18233837216851 3985 6144269
SGTC_2297 7971671 152.32 µM -0.907798093674469 0.19792965585421 no 2722 0.181992452879131 3999 909016
SGTC_2453 5731132 22.18 µM -0.908559900386409 0.197707521314948 no 2723 0.181791240737622 4027 1362040
SGTC_1380 2291-0730 164 µM -0.909442510977987 0.197450350158092 no 2724 0.181558295367663 4023 2999191
SGTC_1732 st034308 51.822 µM -0.910700133019125 0.197084259479572 no 2725 0.181226697000947 3850 830119
SGTC_531 3788-1495 174 µM -0.910720038432576 0.197078468366974 no 2726 0.181221451573345 3937 2896655
SGTC_967 1306-0166 352 µM -0.91176374597696 0.196774965202749 no 2727 0.180946549437317 3942 4437607
SGTC_2746 daunorubicin 9.88 µM -0.911870979959351 0.196743798321773 no 2728 0.180918319889811 3882 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1950 st077106 7.18 µM -0.913095103955382 0.196388226300686 no 2729 0.180596262561702 3970 13831864
SGTC_688 0527-0193 473 µM -0.914144504644589 0.196083716552774 no 2730 0.180320459961319 4007 4007154
SGTC_1378 2093-0007 380 nM -0.91476140566626 0.195904841087833 no 2731 0.180158449978941 4061 3618014
SGTC_94 0334-0113 514.748 µM -0.915247501414036 0.195763963444421 no 2732 0.180030856341472 4012 6795178
SGTC_3354 9151612 71.43 µM -0.916195906524055 0.195489278875286 no 2733 0.179782076064922 4016 27261949
SGTC_206 4546-0025 72.014 µM -0.916574234443172 0.195379769902459 no 2734 0.179682895507875 4041 6620745 YIL048W NEO1
SGTC_1216 1165-0504 9.65 µM -0.917007158677624 0.195254503473656 no 2735 0.179569444441644 4028 6304004
SGTC_1925 st057770 10.1 µM -0.917137852565335 0.195216696849306 no 2736 0.179535203969853 3976 5989122
SGTC_162 k030-0015 37.8 µM -0.917867415754969 0.195005733358963 no 2737 0.179344141220234 4068 1809920 YMR134W ERG29
SGTC_213 1246-0773 967 nM -0.919017468902473 0.194673460853292 no 2738 0.179043217553485 3972 6251622
SGTC_2112 5488546 200 µM -0.919334358507733 0.194581965911711 no 2739 0.178960355870236 3960 600757
SGTC_1369 1866-0067 208 µM -0.921221448841154 0.194037651961899 no 2740 0.178467411095117 3983 3531355
SGTC_3246 9135460 32.98 µM -0.923231285816227 0.193458954170232 no 2741 0.177943344065021 3924 41446951
SGTC_210 3551-0445 56.827 µM -0.924536295641208 0.193083763556773 no 2742 0.177603581622321 4039 2865180 YOR207C RET1
SGTC_970 1315-0089 19.5 µM -0.925518058573302 0.192801799533371 no 2743 0.177348247317035 3935 6811083 YLR033W RSC58
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.9258940149098 0.192693890862165 no 2744 0.177250530991566 4010 688669
SGTC_2113 5491891 107.031 µM -0.926434144429752 0.19253892508238 no 2745 0.177110203281083 4010 789979
SGTC_2973 9094665 17.96 µM -0.929333095635864 0.191708504294385 no 2746 0.176358244350068 4057 25237061 YIL048W NEO1
SGTC_35 0133-0054 64.071 µM -0.9300462515652 0.191504553436407 no 2747 0.176173568872289 4017 99677
SGTC_1299 1079-1439 3.74 µM -0.930419875174281 0.19139775631875 no 2748 0.176076865953327 3961 323161
SGTC_44 0929-0055 61.211 µM -0.93146208959984 0.191100041181268 no 2749 0.175807293044284 3924 1379590
SGTC_483 fpl-64176 144 µM -0.936608647812804 0.189634061788773 no 2750 0.174479951007437 4058 3423
SGTC_350 k064-0020 19.8 µM -0.936849406725206 0.189565652252407 no 2751 0.17441801344002 4024 2790705
SGTC_3188 9110789 49.47 µM -0.940407797341566 0.188556338066214 no 2752 0.173504212072799 4006 849217
SGTC_2627 acetyl isogambogic acid 100 µM -0.94147596856289 0.188254006108548 no 2753 0.173230499384317 4048 6857789 A caspase activator and apoptosis inducer.
SGTC_2873 9040596 71.43 µM -0.941538292853659 0.188236375269047 no 2754 0.173214537640018 4022 6463863
SGTC_1123 mangostin 811.285 nM -0.942386652428665 0.187996485238281 no 2755 0.172997359185521 4040 5281650 An antioxidant.
SGTC_3159 9100096 49.47 µM -0.942457373149426 0.187976496116462 no 2756 0.172979262651096 3976 25236875
SGTC_982 1491-0518 27.5 µM -0.943212754680206 0.187763070352363 no 2757 0.172786045354306 3947 3091256
SGTC_3349 9149703 23.001 µM -0.943708363544518 0.187623122196044 no 2758 0.172659349471905 4031 4910494
SGTC_3082 9117008 49.47 µM -0.944250581170881 0.187470086677367 no 2759 0.172520806535345 4096 41448529
SGTC_2219 9098279 200 µM -0.944475862750276 0.18740652588937 no 2760 0.172463265312912 3964 902349
SGTC_2540 epiandrosterone 100 µM -0.944683637234228 0.187347916350612 no 2761 0.172410206589223 4050 441302 A steroid.
SGTC_2309 7664088 163.95 µM -0.94561547868024 0.187085199612373 no 2762 0.172172373220419 4047 704922
SGTC_329 k048-0121 21.3 µM -0.946571521474797 0.186815896677473 no 2763 0.171928580664363 4047 6832902
SGTC_1608 st001473 40.5 µM -0.948457369009224 0.186285385506904 no 2764 0.171448332846015 4009 7292267
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.948771898788377 0.186196995480461 no 2765 0.171368318546431 4035 7104
SGTC_2168 5727979 200 µM -0.949178146082022 0.186082869217404 no 2766 0.171265007248387 3916 695210
SGTC_1066 ketoconazole 628 nM -0.951842148687545 0.185335551076909 no 2767 0.170588521299005 4102 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1786 berberine 21.6 µM -0.952058602403558 0.185274912457051 no 2768 0.170533631174567 3947 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1432 4049-0298 68.4 µM -0.952519487680554 0.185145838387564 no 2769 0.170416793753083 4046 741646
SGTC_3029 9088683 49.47 µM -0.954545427283118 0.184579122781052 no 2770 0.16990381303867 4079 25236615
SGTC_3139 9095020 49.47 µM -0.955009610194632 0.18444942905868 no 2771 0.169786418534756 3729 25236292
SGTC_980 1473-0395 201 µM -0.955882619683155 0.184205661901858 no 2772 0.169565770407253 3922 768876
SGTC_1355 1499-0035 1.68 µM -0.956912122898085 0.183918455358458 no 2773 0.169305805890834 4022 1548538
SGTC_3330 9141424 71.43 µM -0.958270938478959 0.183539805815003 no 2774 0.168963077114968 4115 27261020
SGTC_1239 0337-0584 35.4 µM -0.958312159487114 0.183528326706639 no 2775 0.168952687069789 4122 914301 YML130C ERO1
SGTC_1304 1165-0502 251 µM -0.959207929590692 0.183278985736911 no 2776 0.16872700328169 4048 767425
SGTC_491 tetrandrine 80.3 µM -0.959650766342315 0.183155798532309 no 2777 0.168615504872337 4052 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_821 1114-0266 29.2 µM -0.959656610748185 0.183154173095679 no 2778 0.168614033671728 4066 3123235
SGTC_1520 flindersine 88 µM -0.961293994547186 0.182699141009161 no 2779 0.168202183320913 4166 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2730 imipramine 71.33 µM -0.964414615635663 0.181833870977605 no 2780 0.167419048740921 4026 3696 A tricyclic antidepressant.
SGTC_805 3852-0218 479 µM -0.968134716992804 0.180805735367246 no 2781 0.166488546711932 3998 6615355
SGTC_1462 k081-0014 26.5 µM -0.970431959104001 0.180172663314192 no 2782 0.16591561246425 3656 3270634
SGTC_75 0159-0059 199.013 µM -0.971912593570132 0.179765369617018 no 2783 0.165547017038756 4157 5377270
SGTC_2521 angolensin 13.4 µM -0.976205481473633 0.178587752789823 no 2784 0.164481323709612 4130 821428 A flavenoid.
SGTC_2150 5556613 200 µM -0.976363901758236 0.178544388394831 no 2785 0.164442081729392 4061 743190
SGTC_1157 4092-0394 27.6 µM -0.977465221452093 0.178243107417026 no 2786 0.164169443732772 4162 3659885
SGTC_2920 7982904 15.77 µM -0.978103277910032 0.178068705069895 no 2787 0.164011623405297 4074 6456808
SGTC_873 0591-4978 488 µM -0.978552407263004 0.177946007411442 no 2788 0.163900592374369 4152 3305145
SGTC_2319 6033012 152.6 µM -0.981298982057276 0.177196830964884 no 2789 0.163222662294379 4021 847246
SGTC_1105 epirubicin 18.1 µM -0.98139752669975 0.177169988258191 no 2790 0.1631983726783 4094 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3326 9140064 16.379 µM -0.981679418010714 0.177093217690477 no 2791 0.163128904126725 3998 1868434
SGTC_1821 st053465 65.6 µM -0.982212504756832 0.176948093760689 no 2792 0.162997584179277 4069 675086
SGTC_773 4358-1457 44.6 µM -0.985133214959219 0.17615431377912 no 2793 0.162279320032846 4050 1186886
SGTC_2614 arthonioic acid 13.39 µM -0.985273177512302 0.176116331943977 no 2794 0.162244952108188 3950 6710684
SGTC_2567 aureobasidin a 60 nM -0.985982265105211 0.175923985516391 no 2795 0.162070907866948 4234 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3125 9127534 49.47 µM -0.986094586000928 0.175893529666601 no 2796 0.162043350070358 3958 1639235
SGTC_3322 9139058 2.11 µM -0.986549311354562 0.17577026485531 no 2797 0.161931814942242 4156 4908926 YPR165W RHO1
SGTC_1718 roemerine 11.9335 µM -0.989657897094225 0.174929070307597 no 2798 0.161170680318015 3836 235224 An aporphine alkaloid with mutagenic activity.
SGTC_122 0236-0016 402.397 µM -0.992396596924668 0.174190088658958 no 2799 0.160502049189015 4078 6808838
SGTC_1026 k007-1105 30.6 µM -0.994439591141281 0.173640122814827 no 2800 0.160004450715503 4061 7066794
SGTC_2145 5634607 200 µM -0.996916293505103 0.172974887702715 no 2801 0.159402571103949 4055 308662
SGTC_2406 ethylparaben 405.7 µM -0.999625849873661 0.172248971230729 no 2802 0.158745804245143 4109 8434 A possible steroid mimic.
SGTC_1667 st014849 34.6 µM -1.00026963577124 0.172076780941184 no 2803 0.158590018764586 4135 5348460
SGTC_2608 thymoquinone 42.66 µM -1.00243873475133 0.171497431632224 no 2804 0.158065871067688 4079 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2648 atorvastatin 78.68 µM -1.00429852440611 0.171001690170932 no 2805 0.157617372343965 4104 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_486 niguldipine 82 µM -1.00474104849859 0.170883867063022 no 2806 0.157510778434519 4145 1236 A calcium channel blocker.
SGTC_1302 1159-0335 255 µM -1.00517768447809 0.170767662604494 no 2807 0.157405649278475 4103 649284
SGTC_2034 5197015 53.07 µM -1.00575214200735 0.170614855957474 no 2808 0.157267406999689 4107 780676
SGTC_1053 3366-3204 134 µM -1.00729843414041 0.170203974805213 no 2809 0.156895691021855 4134 3632071 YPR165W RHO1
SGTC_1451 4152-0210 104 µM -1.00822448755715 0.169958207452836 no 2810 0.156673352341884 4140 659563
SGTC_2148 5546263 113.568 µM -1.00995057919887 0.169500723731614 no 2811 0.156259484123883 4082 792097
SGTC_128 0906-2981 13.371 µM -1.01165238169393 0.16905045190698 no 2812 0.155852145470148 4088 6740226
SGTC_1793 st048256 72.231 µM -1.0126684245723 0.168781988534473 no 2813 0.155609282358664 3982 672022
SGTC_3099 9120367 49.47 µM -1.0134780284344 0.168568267627593 no 2814 0.155415942830752 4132 24824940
SGTC_2224 6650123 117.647 µM -1.0150215707319 0.16816128239448 no 2815 0.15504777260954 4074 2908370
SGTC_338 4055-0136 114 µM -1.01537125309232 0.168069169682032 no 2816 0.154964445429218 4055 2900563
SGTC_510 ag-490 170 µM -1.01814592748536 0.167339421106 no 2817 0.15430430594948 4216 5328779
SGTC_117 lucigenin 22.078 µM -1.02012154325943 0.166821074080132 no 2818 0.153835410368947 4128 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1666 st014829 29 µM -1.02188297934924 0.166359796325987 no 2819 0.153418144589763 4095 3858230
SGTC_979 1426-2828 121 µM -1.02416335693632 0.165763844819218 no 2820 0.152879061565886 4214 747872
SGTC_587 k089-0003 57 µM -1.02433430227434 0.165719225821157 no 2821 0.152838700626149 3986 9659696
SGTC_1147 3809-1045 12.3 µM -1.03211109162462 0.163697594904161 no 2822 0.151010039220492 4102 325925
SGTC_2528 xanthyletin 44.79 µM -1.03249651586706 0.163597819316431 no 2823 0.150919789495356 4159 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_66 0109-0187 42.4 µM -1.03284373730043 0.163507967187991 no 2824 0.1508385159649 4023 759417
SGTC_212 3807-4682 38.772 µM -1.03289511262264 0.163494675275765 no 2825 0.150826493105511 4190 3125501 YBL034C STU1
SGTC_126 0417-1624 672.48 µM -1.03605905604389 0.162677446801964 no 2826 0.15008729605978 4194 41912 YDL195W SEC31
SGTC_3205 9113483 49.47 µM -1.03690784207935 0.162458663048246 no 2827 0.149889404414667 4178 17018033
SGTC_2250 alverine citrate 130 µM -1.04052770155766 0.161527755995703 no 2828 0.149047400476772 4015 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_378 3970-0959 8.33 µM -1.04205277627082 0.16113660100346 no 2829 0.148693605538735 4169 6615653
SGTC_927 2425-1185 123 µM -1.04349855426076 0.160766355391371 no 2830 0.148358725026812 4072 730375
SGTC_801 0866-0028 10.1 µM -1.04360063274843 0.160740235381843 no 2831 0.148335100023959 4158 6849771
SGTC_1027 k015-0025 8.67 µM -1.04365067447106 0.16072743163672 no 2832 0.148323519307686 4097 3598955
SGTC_889 0919-1524 82.7 µM -1.04546984909584 0.160262427268356 no 2833 0.147902934314351 4163 3905452
SGTC_1165 k072-0275 30.3 µM -1.04634701229963 0.160038527625255 no 2834 0.147700423697225 4117 6153523 YGL055W OLE1
SGTC_619 1652-1634 108 µM -1.04650076275914 0.15999930324435 no 2835 0.147664946474185 4113 5400454
SGTC_1743 st037606 46.3785 µM -1.04702441763771 0.159865757071497 no 2836 0.147544158304647 4112 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.04892185744739 0.159382469471276 no 2837 0.147107042385581 4214 6710655
SGTC_2393 9031399 185.94 µM -1.05749742910498 0.157210171647908 no 2838 0.145142313661977 4205 1526623 YDL150W RPC53
SGTC_2552 juarezic acid 87.02 µM -1.05964218676769 0.156669935853061 no 2839 0.144653706743759 4121 1549512
SGTC_144 4161-2749 112.381 µM -1.06048988289285 0.156456749860891 no 2840 0.144460895114132 4101 797501 YMR168C CEP3
SGTC_2862 9027634 71.43 µM -1.06287755259962 0.155857305171902 no 2841 0.143918741983739 4101 5012562
SGTC_640 3381-0960 37.1 µM -1.06314969794896 0.155789077032742 no 2842 0.143857034897169 4221 1745025
SGTC_583 1488-1091 88.9 µM -1.06362433692772 0.155670129905286 no 2843 0.143749456488578 4269 4303273
SGTC_1428 4049-0204 61.7 µM -1.06385015072348 0.155613560763485 no 2844 0.14369829414665 4218 X1428
SGTC_804 1595-0054 20.9 µM -1.06604584098701 0.155064220228595 no 2845 0.143201460068425 4097 761523 Stimulates phospholipase C.
SGTC_974 1326-0144 138 µM -1.07433561123095 0.153001755981762 no 2846 0.141336144878138 4195 5411856
SGTC_1137 ixabepilone 100 µM -1.07570668146192 0.152662399515165 no 2847 0.141029229167785 4127 154225 A novel microtubule stabilizer.
SGTC_2274 7947094 46.08 µM -1.07666169396233 0.152426317616284 no 2848 0.140815715745253 4116 2971028
SGTC_471 1-acyl-paf 4 µM -1.08152180963907 0.151228638503999 no 2849 0.139732532274233 4102 16759367
SGTC_2234 tolnaftate 200 µM -1.08244206715292 0.15100256610023 no 2850 0.139528072234319 4223 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_264 promethazine 12.5 mM -1.08434825702173 0.150535003240572 no 2851 0.139105208219197 4055 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.08476629910871 0.150432592184502 no 2852 0.139012587641585 4184 5024745
SGTC_1964 st076914 61 µM -1.08549911891514 0.15025317958315 no 2853 0.138850326858333 4218 24208661
SGTC_2264 7948757 110.76 µM -1.08692318220886 0.149904941274922 no 2854 0.138535380073029 4142 2971411
SGTC_2171 5739187 198.077 µM -1.08744713613578 0.149776949925366 no 2855 0.138419624662113 4115 2262761
SGTC_1878 temozolomide 1 mM -1.09003786581407 0.149145158649149 no 2856 0.137848232229567 4104 5394 DNA alkylating agent.
SGTC_1937 st074714 47.2 µM -1.09187825401823 0.148697433091546 no 2857 0.137443308568453 4129 17250970
SGTC_1179 1021-1431 9.29 µM -1.09520336554986 0.147890787476897 no 2858 0.136713775788662 4203 2840958
SGTC_313 3474-0040 5.03 µM -1.09538971207589 0.147845668144145 no 2859 0.136672969663499 4186 1043375 YIL048W NEO1
SGTC_23 0213-0011 39.996 µM -1.09601096877884 0.147695312351132 no 2860 0.136536987161074 4193 627608
SGTC_315 k915-0449 187 µM -1.09702330064837 0.147450528483035 no 2861 0.136315603262422 4197 20970215 YNL149C PGA2
SGTC_389 tpck 16.7 µM -1.09702629250322 0.147449805449659 no 2862 0.136314949346627 4206 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_836 0330-0104 1.35 µM -1.09726721169477 0.147391590965318 no 2863 0.136262299804502 4209 46494820
SGTC_1340 1486-1359 257 µM -1.09756167434317 0.147320459432162 no 2864 0.13619796798286 4112 4309068
SGTC_2736 butenafine 14.65 µM -1.09878698078461 0.14702471676493 no 2865 0.135930496139912 4111 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3145 9085516 49.47 µM -1.09935907082825 0.146886772275744 no 2866 0.135805737984124 4217 25236195
SGTC_1326 1431-2094 10.8 µM -1.10051710154953 0.146607809373707 no 2867 0.135553441285818 4169 616278
SGTC_706 4262-0057 46.9 µM -1.10220986216461 0.146200673246177 no 2868 0.135185222713673 4200 883298
SGTC_1615 st002656 86.5 µM -1.10416694517624 0.145730910672573 no 2869 0.134760362774923 4193 1584458
SGTC_1150 3909-7983 10.9 µM -1.10721313120633 0.145001749313207 no 2870 0.134100895778402 4180 23965914
SGTC_2785 7756463 72.73 µM -1.1078409482542 0.144851775378796 no 2871 0.133965256065909 4154 2201551
SGTC_864 0469-0573 172 µM -1.1098224388489 0.144379118992183 no 2872 0.133537774012102 4190 689425
SGTC_1531 st059297 52.4 µM -1.11248583266655 0.143745443523792 no 2873 0.132964659101146 4219 7566702
SGTC_2923 7992654 58.14 µM -1.11602024523451 0.14290743658311 no 2874 0.132206734383458 4209 2985126
SGTC_3119 9125183 49.47 µM -1.11668000074418 0.142751375394668 no 2875 0.132065585958045 4024 22695334
SGTC_1610 st001799 48.1 µM -1.11753311554457 0.142549747098238 no 2876 0.131883224260164 4133 621897
SGTC_2388 9080168 200 µM -1.11753697287587 0.142548835879935 no 2877 0.131882400112243 4205 15943073
SGTC_169 k015-0017 16.025 µM -1.12039847827778 0.141873946983466 no 2878 0.13127199656152 4182 1840002
SGTC_1412 3909-8563 178 µM -1.12677455554398 0.140377934978431 no 2879 0.129918905513218 4290 23767530
SGTC_2617 dihydrotanshinone i 20.83 µM -1.12859560680739 0.139952637447615 no 2880 0.129534232401272 4189 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1029 k015-0030 64.7 µM -1.12949909350787 0.139741957909025 no 2881 0.12934367586924 4268 2208316
SGTC_850 0388-0143 75.9 µM -1.13029663817684 0.139556161720463 no 2882 0.129175625336408 4198 67273
SGTC_1870 st057514 26.5 µM -1.13367991263376 0.138769861807025 no 2883 0.128464419303461 4219 5393161
SGTC_1012 4112-3522 18 µM -1.1352264107062 0.138411450102847 no 2884 0.128140233164723 4259 3112398
SGTC_2767 sibutramine 71.45 µM -1.13567254138882 0.138308173563764 no 2885 0.128046818286125 4259 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_148 3253-0744 288.01 µM -1.13578327690741 0.138282547104356 no 2886 0.12802363881161 4106 6893655
SGTC_2235 salicylic acid 500 µM -1.13596105692622 0.138241411949122 no 2887 0.12798643148797 4245 338 A COX inhibitor and kinase inhibitor.
SGTC_1777 st045864 34.765 µM -1.13640247600567 0.138139311448201 no 2888 0.127894080012478 4216 4691462
SGTC_1390 3413-2614 145 µM -1.13749543861215 0.137886729852424 no 2889 0.127665615180255 4249 3421432
SGTC_1081 sertraline 6 µM -1.13823617252786 0.137715726871714 no 2890 0.127510939018786 4216 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2011 4012611 177 µM -1.13953654505245 0.137415878038981 no 2891 0.127239717342986 4213 2049887
SGTC_2990 9074105 71.4286 µM -1.14052065909925 0.137189250804406 no 2892 0.127034725402501 4144 6502001
SGTC_2951 9072950 58.06 µM -1.14207007594852 0.136832960172731 no 2893 0.126712446330977 4198 16488155
SGTC_1846 st056244 14.8 µM -1.14370854364001 0.136456880792431 no 2894 0.126372264502798 4256 5393182
SGTC_1764 st044502 93.5 µM -1.14566430804329 0.136008898376093 no 2895 0.125967038718194 4279 8407
SGTC_960 1222-0186 7.7 µM -1.14671005557147 0.135769775663447 no 2896 0.125750736583972 4255 3126296
SGTC_3160 9100216 49.47 µM -1.14926263018737 0.135187308587312 no 2897 0.125223851212489 4211 17191039
SGTC_2082 5219693 150 µM -1.15233489317585 0.13448852981035 no 2898 0.124591741864443 4231 2834649
SGTC_2154 5570129 200 µM -1.15295350777314 0.134348127869162 no 2899 0.124464733924612 4297 673366
SGTC_2134 5324836 1.464 µM -1.1559196489856 0.133676325368985 no 2900 0.123857012366168 4188 699272
SGTC_3351 9150312 21.596 µM -1.15628002198626 0.133594861975263 no 2901 0.123783318640526 4161 4904905
SGTC_1597 7-benzyloxygramine 47.5 µM -1.15670175854463 0.133499570525916 no 2902 0.1236971154897 4169 260807
SGTC_2041 5107442 45.335 µM -1.15941645167603 0.132887304123831 no 2903 0.123143237002812 4287 793005
SGTC_3153 9100258 49.47 µM -1.15960831512094 0.132844104901389 no 2904 0.123104157000816 4187 25236848
SGTC_2982 9019404 25.97 µM -1.16245473614213 0.132204351683998 no 2905 0.122525400299323 4194 22333232
SGTC_300 r073-0011 5.04 µM -1.16447124349234 0.131752414797165 no 2906 0.122116545237275 4248 2735780
SGTC_3278 9139605 49.47 µM -1.16898830223578 0.130743929382023 no 2907 0.121204172205044 4261 7958859
SGTC_1596 piperlongumine 63 µM -1.16899890953211 0.130741567478034 no 2908 0.121202035359837 4300 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2474 5321570 43.32 µM -1.16969881311462 0.130585786620555 no 2909 0.121061097979473 4243 2841384
SGTC_918 glabranin 770.725 nM -1.17052704768763 0.130401608386894 no 2910 0.120894467984163 4264 124049 Also referred to as licorice root.
SGTC_969 1313-0238 134 µM -1.17077244755176 0.130347072241289 no 2911 0.120845127741439 4289 5212874
SGTC_488 nitrendipine 139 µM -1.17093020470345 0.130312021601825 no 2912 0.120813416479333 4288 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_698 k064-0052 127 µM -1.17173255470099 0.130133855604629 no 2913 0.120652224222431 4346 5088751
SGTC_1215 3852-0577 11.2 µM -1.17238625216403 0.129988823349889 no 2914 0.120521008264387 4306 2884876
SGTC_3102 9121669 49.47 µM -1.17245321192357 0.129973973676786 no 2915 0.12050757318316 4300 41905072
SGTC_1513 0337-0559 19 µM -1.17248461031332 0.129967010856941 no 2916 0.120501273644496 4242 775073
SGTC_2300 7976697 71.57 µM -1.17306628729304 0.129838066481924 no 2917 0.120384612256224 4150 2236109
SGTC_3216 9129716 49.47 µM -1.17332660920348 0.129780387817838 no 2918 0.12033242775721 4194 8056934
SGTC_1065 prochlorperazine maleate 2.48 µM -1.17555714919892 0.129286901777278 no 2919 0.119885943711769 4293 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2294 7971431 200 µM -1.17755630761933 0.128845713257487 no 2920 0.119486768581171 4261 5741572
SGTC_849 0386-0493 241 µM -1.17787984135741 0.128774411825476 no 2921 0.119422256343553 4253 726119
SGTC_1695 st026914 34.495 µM -1.17889500112057 0.128550865283754 no 2922 0.119219994258453 4249 3289191
SGTC_1754 st042065 16.137 µM -1.17957240731118 0.128401844768825 no 2923 0.119085161324095 4035 1126236 YIL048W NEO1
SGTC_2506 ethyl hematommate 54.16 µM -1.17978984842016 0.128354036000605 no 2924 0.119041904035724 4325 3940691 An allergen.
SGTC_2271 7849410 118.62 µM -1.18078586383126 0.128135200100905 no 2925 0.118843900576408 4212 972430
SGTC_2438 5259590 200 µM -1.18227118691029 0.127809339349898 no 2926 0.118549057206969 4288 1201127
SGTC_786 4544-0069 423 µM -1.18388609475302 0.127455703349385 no 2927 0.118229077638338 4257 748821 YLR208W SEC13
SGTC_1175 0741-0056 27.6 µM -1.18791711727028 0.126575952270757 no 2928 0.117433032586938 4350 765927
SGTC_2534 helenine 20.12 µM -1.18867280960517 0.126411498008884 no 2929 0.117284222137383 4295 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2120 5538279 151.968 µM -1.19123143524084 0.125855793790615 no 2930 0.116781371045799 4234 2058197
SGTC_2954 9074818 52.69 µM -1.19193707254074 0.125702837625031 no 2931 0.116642960211252 4299 16648742
SGTC_2383 9036125 200 µM -1.19255819854657 0.125568307751447 no 2932 0.116521222572066 4198 79580
SGTC_1822 st052468 42 µM -1.19485729434673 0.125071220220716 no 2933 0.116071395302945 4273 2873678
SGTC_1906 st060206 94.7 µM -1.19558261396706 0.124914684434291 no 2934 0.115929739736863 4307 5133468
SGTC_771 0250-0039 27.3 µM -1.19711967131255 0.124583414921952 no 2935 0.115629956840509 4244 3005115
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.20076822770087 0.12379953164111 no 2936 0.114920559870799 4386 688801
SGTC_904 1141-0088 396 µM -1.20129633776425 0.123686355192482 no 2937 0.114818135271098 4294 1378119
SGTC_225 nsc-122657 1.016 µM -1.20139599201926 0.12366500694857 no 2938 0.11479881505704 4289 275685
SGTC_779 1360-0071 233 µM -1.20328828382591 0.123260123897768 no 2939 0.11443239066801 4334 7566
SGTC_2569 tetrandrine 100 µM -1.20524257042666 0.122842952146607 no 2940 0.114054836358465 4297 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_136 0097-0015 404.482 µM -1.20534023055887 0.122822131134932 no 2941 0.114035992421809 4289 4861337
SGTC_1951 sophoraflavanone G 9.2 µM -1.20544435644626 0.122799934358921 no 2942 0.114015903333466 4245 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1075 aripiprazole 15.2 µM -1.2074577475322 0.122371287780837 no 2943 0.113627953839783 4349 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1737 st035557 69.7 µM -1.20988726627697 0.121855448050769 no 2944 0.113161077028731 4152 5716916
SGTC_188 3229-0966 278.469 µM -1.21047429196453 0.121731039185084 no 2945 0.113048474824192 4340 5722370
SGTC_2342 7990637 118.86 µM -1.21094082037423 0.121632231081956 no 2946 0.112959043232369 4317 2033102 YER133W GLC7
SGTC_1006 4099-6547 255 µM -1.21098613027439 0.121622637702777 no 2947 0.112950360200574 4306 3146833
SGTC_1525 8-methoxypsoralen 92.5 µM -1.21475161901953 0.120827235633496 no 2948 0.112230419220785 4342 4114 Related to psoralen; DNA damaging agent.
SGTC_3192 9110362 49.47 µM -1.21485679419685 0.120805071662413 no 2949 0.112210357488133 4311 16649480
SGTC_296 1222-0039 74.9 µM -1.21501558707188 0.120771614048761 no 2950 0.11218007325635 4307 5984176
SGTC_2804 7954240 19.48 µM -1.21705678289956 0.120342115374756 no 2951 0.111791306077126 4323 828705
SGTC_133 0724-0033 378.92 µM -1.21735824726976 0.12027877398336 no 2952 0.111733970791723 4129 280309
SGTC_2558 carylophyllene oxide 100 µM -1.21933586975042 0.119863833453445 no 2953 0.111358369794222 4414 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1927 st060202 13.8 µM -1.21952615757574 0.119823960958568 no 2954 0.111322276999076 4228 688887
SGTC_1093 fluphenazine 7.97 µM -1.22029369137434 0.119663228541724 no 2955 0.111176780229721 4325 6602611 An atypical antipsychotic.
SGTC_2864 9034755 47.6 µM -1.220999697241 0.119515515263155 no 2956 0.111043067211537 4230 4930451
SGTC_2970 9090938 41.86 µM -1.22104929822966 0.119505142390613 no 2957 0.111033677431939 4376 17217104
SGTC_749 1000-0129 128 µM -1.22192416639706 0.119322288812602 no 2958 0.110868152840413 4350 708470
SGTC_1553 gossypol 38.6 µM -1.22261928825895 0.119177144301033 no 2959 0.110736762241218 4184 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1984 st072354 53.1 µM -1.22425318990727 0.11883646930565 no 2960 0.110428364755384 4180 5762938
SGTC_1962 st076595 64.5 µM -1.2248586350946 0.118710406407052 no 2961 0.11031424402605 4281 279619
SGTC_589 1227-0070 34.1 µM -1.22547400294117 0.118582374301992 no 2962 0.110198339658481 4359 2841384
SGTC_2028 5153890 36.43 µM -1.22721547544182 0.118220576197917 no 2963 0.109870807213154 4293 2830968 YPR165W RHO1
SGTC_56 0957-0365 83.25 µM -1.23282785330776 0.117059895008032 no 2964 0.108819998590753 4271 6752360
SGTC_1713 st033146 12.748 µM -1.23545442916559 0.116519482370014 no 2965 0.108330713287972 4305 674619
SGTC_2097 5376186 200 µM -1.23675469826989 0.116252610440358 no 2966 0.108089082526215 4308 742755
SGTC_1108 betulinic acid 729.144 nM -1.23840228130603 0.115915077909268 no 2967 0.107783467589087 4309 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1342 1486-1464 234 µM -1.2394709177743 0.115696523781455 no 2968 0.107585576202123 4348 3253938
SGTC_208 k072-0098 12.366 µM -1.24236554481477 0.115105994527083 no 2969 0.107050861049689 4295 5948901
SGTC_16 erodoxin 22.806 µM -1.24365873272983 0.114842866654288 no 2970 0.106812595068654 4333 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3147 9097027 49.47 µM -1.24665500180969 0.114234853964267 no 2971 0.106262012455465 4313 25236841
SGTC_2903 5923464 63.88 µM -1.2471091039347 0.114142906493346 no 2972 0.106178747632857 4332 2876576
SGTC_2105 5350118 200 µM -1.24934592015751 0.113690760978274 no 2973 0.10576928959478 4293 2133313
SGTC_1843 st055809 45.5 µM -1.25231376469458 0.113092819717124 no 2974 0.105227777582322 4386 16413835
SGTC_87 0100-0052 35.5 µM -1.25535713151473 0.112481996716463 no 2975 0.104674571989151 4371 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2122 5258151 111.688 µM -1.25678199076807 0.11219682987 no 2976 0.10441629452159 4336 2173356
SGTC_2965 9082772 38.63 µM -1.25702819191568 0.112147608349301 no 2977 0.104371713638407 4338 16459634
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.25780293289983 0.111992819736454 no 2978 0.104231517379183 4355 6728940
SGTC_1240 0356-0016 42.1 µM -1.25806095767787 0.111941301853812 no 2979 0.104184855819241 4308 4305613
SGTC_3175 9106517 49.47 µM -1.25882011755358 0.111789824345809 no 2980 0.104047656111846 4342 41468073
SGTC_2368 9071271 200 µM -1.26005289960612 0.111544155985587 no 2981 0.103825139875798 4321 27209959
SGTC_1591 genipin 88.4 µM -1.2602517506336 0.111504565235135 no 2982 0.103789279768321 4362 442424 A DNA cross-linking agent.
SGTC_643 k048-0106 28.4 µM -1.26113139892167 0.1113295500561 no 2983 0.103630754814644 4359 6763920
SGTC_373 0844-0104 25.9 µM -1.26125352177871 0.111305267996454 no 2984 0.103608760459875 4351 5375804
SGTC_397 arbidol 50 µM -1.26145240109821 0.111265732330488 no 2985 0.103572949498606 4370 131410 A RNA synthesis inhibitor.
SGTC_2759 disulfiram 3.38 µM -1.26154467682139 0.111247392047383 no 2986 0.10355633703437 4243 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3309 9129340 25.759 µM -1.26210338321999 0.111136392448892 no 2987 0.103455794019742 4354 17158987
SGTC_935 2996-0153 430 µM -1.26509090069998 0.110544200623169 no 2988 0.102919372179253 4334 23738523
SGTC_2780 5215298 71.43 µM -1.26611114213945 0.110342485331516 no 2989 0.102736647030616 4361 2834131
SGTC_2947 9072639 7.68 µM -1.26701983185831 0.110163047647239 no 2990 0.102574099392952 4322 16488146
SGTC_681 1642-0006 26.6 µM -1.26808348403135 0.109953275755869 no 2991 0.102384069459537 4354 4446530
SGTC_2702 st077768 96.8 µM -1.27028265039951 0.109520468756422 no 2992 0.101991982988516 4313 6484119
SGTC_1658 st012944 20 µM -1.27104368282666 0.109370979066281 no 2993 0.101856554328365 4186 24207260
SGTC_2189 6047310 154.431 µM -1.27154510283586 0.109272565205889 no 2994 0.101767396259576 4310 711535
SGTC_2351 9026858 72.31 µM -1.27170432301674 0.109241328324235 no 2995 0.101739097024027 4240 1409300
SGTC_566 0958-0068 16.5 µM -1.27329519006149 0.108929573618166 no 2996 0.101456656448978 4253 6815365
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.27334370144055 0.108920077131363 no 2997 0.101448052780741 4412 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_170 4197-0004 226 µM -1.27378212025063 0.108834280169484 no 2998 0.101370321724732 4338 218692
SGTC_153 4077-0274 519.67 µM -1.27411506005379 0.108769157534099 no 2999 0.101311320944572 4394 3121976
SGTC_2245 6637752 200 µM -1.2747496403476 0.108645111981078 no 3000 0.101198935279388 4387 681890
SGTC_2848 9016370 25.97 µM -1.27531189972607 0.108535288512709 no 3001 0.101099433750105 4338 7894410
SGTC_1564 D-Arginine 115 µM -1.27536082299039 0.108525736340693 no 3002 0.101090779304897 4359 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3284 9108171 64.8615 µM -1.27799612588487 0.108012091946956 no 3003 0.100625396133694 4328 8687505
SGTC_2813 7971799 71.43 µM -1.27831646724614 0.107949774037309 no 3004 0.100568931929037 4359 2234054
SGTC_1098 clofazimine 15.1 µM -1.28325708572507 0.106991923428668 no 3005 0.0997010110691665 4404 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_301 4119-0100 24.5 µM -1.28362619289056 0.106920610558436 no 3006 0.0996363902089017 4384 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_433 pimozide 108 µM -1.28418101755578 0.106813480901408 no 3007 0.0995393127323847 4278 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1058 3448-5425 97.3 µM -1.28963667309343 0.105764185733485 no 3008 0.0985884181992667 4306 7279705
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.29118143388705 0.105468437534987 no 3009 0.0983203857315226 4380 6708561
SGTC_2173 5763948 167 µM -1.2923385596886 0.105247295155321 no 3010 0.0981199619541877 4338 2867177
SGTC_261 5-fluorouridine 15.376 µM -1.29422106821285 0.104888239564132 no 3011 0.0977945357517448 4373 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1607 st000305 50.6 µM -1.29492437375742 0.104754324142159 no 3012 0.0976731596938256 4364 5457690
SGTC_347 4534-1311 26.2 µM -1.29882641180039 0.104013591319202 no 3013 0.09700175419276 4368 2862016
SGTC_2618 avocadyne 43.43 µM -1.29991879522478 0.10380690377666 no 3014 0.0968144012681446 4286 3015189
SGTC_221 trifluoperazine 10.304 µM -1.3021734687866 0.103381244172748 no 3015 0.09642854629785 4356 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2665 lovastatin 100 µM -1.3037759559146 0.103079482023748 no 3016 0.0961549914486575 4389 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_627 1391-0720 175 µM -1.304512023766 0.102941088715466 no 3017 0.0960295313193445 4340 997839
SGTC_1274 0865-0114 173 µM -1.30457166951498 0.102929880212633 no 3018 0.0960193701895925 4364 870624
SGTC_2777 climbazole 1.536 µM -1.30526397288042 0.102799848894498 no 3019 0.0959014886203826 4200 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.30727388810108 0.102423014621798 no 3020 0.0955598545660225 4323 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2030 5175110 200 µM -1.30775720133764 0.102332549357228 no 3021 0.0954778374473142 4374 2831986
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.3108233618318 0.101759987182053 no 3022 0.0949587239051091 4427 165506
SGTC_2854 9024559 71.43 µM -1.3119655616086 0.101547294807287 no 3023 0.0947658772963526 4387 3163529
SGTC_3341 9147222 25.867 µM -1.3125722671776 0.101434450125485 no 3024 0.094663559845846 4374 1939759
SGTC_2688 kanamycin b 96.69 µM -1.31357582796535 0.101247992594263 no 3025 0.0944944937882136 4385 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1169 aniline yellow 25.8 µM -1.31491181523442 0.101000159270803 no 3026 0.0942697706979132 4300 6051 A DNA damaging agent.
SGTC_1771 st048882 4.1505 µM -1.316050983725 0.10078918650148 no 3027 0.0940784655605422 4407 4580403
SGTC_1341 1486-1360 280 µM -1.31625270531482 0.100751861397594 no 3028 0.0940446195170973 4360 3976547
SGTC_1905 st060207 84.5 µM -1.31661896300181 0.1006841174933 no 3029 0.0939831895999369 4355 1948547
SGTC_2827 7993847 71.43 µM -1.31720107304831 0.100576517387498 no 3030 0.093885617168126 4426 2985692
SGTC_1804 st050076 49.1 µM -1.31837922500302 0.100358998690502 no 3031 0.0936883658937016 4408 3895976
SGTC_1198 1612-1005 86.7 µM -1.32049666403618 0.099968925548537 no 3032 0.0933346245442886 4449 6998509
SGTC_1426 4048-4480 71.7 µM -1.32146786987083 0.0997903815324245 no 3033 0.0931727044692981 4403 14224343
SGTC_2222 6885208 172.143 µM -1.32173274685796 0.099741727672207 no 3034 0.093128580052411 4375 609514
SGTC_856 0433-0016 11.3 µM -1.32177044181251 0.0997348050931992 no 3035 0.0931223019103766 4409 3911780
SGTC_2367 9070478 135.38 µM -1.32666552530409 0.0988388159022725 no 3036 0.0923096749211029 4320 572802
SGTC_1307 1187-1599 12.2 µM -1.32995292862854 0.0982404090879055 no 3037 0.0917668904173558 4383 1538471
SGTC_733 4069-0007 56.1 µM -1.3304289884541 0.0981539722498949 no 3038 0.0916884843737446 4396 5717425 YNL287W SEC21
SGTC_2208 7283366 200 µM -1.33288074180914 0.0977096965541912 no 3039 0.0912854716946352 4373 898663
SGTC_3221 9128209 49.47 µM -1.33313340772531 0.0976639955697854 no 3040 0.0912440139102885 4412 16460723
SGTC_1791 st048313 56.1 µM -1.33342546211543 0.0976111897199362 no 3041 0.0911961106054674 4406 1204976
SGTC_1759 st043059 70 µM -1.33551360779256 0.0972342455825919 no 3042 0.0908541522868987 4393 669426
SGTC_2984 9022109 38.96 µM -1.33569934688894 0.0972007684659938 no 3043 0.0908237814717849 4415 6459207
SGTC_290 2043-6722 48.1 µM -1.33791127126419 0.09680274707271 no 3044 0.0904626812351106 4408 773758 YLR208W SEC13
SGTC_2132 5317594 122.667 µM -1.3393823383203 0.0965387016093014 no 3045 0.0902231180485176 4334 794577
SGTC_2442 5158906 48.48 µM -1.33963398784978 0.0964935854630649 no 3046 0.090182184181171 4401 1893835
SGTC_1424 4048-1941 275 µM -1.34043939327568 0.0963492951704345 no 3047 0.0900512678916618 4462 X1424
SGTC_3223 9129970 49.47 µM -1.34105576411202 0.0962389780270953 no 3048 0.0899511740428514 4411 17248386
SGTC_1445 4239-0156 97.7 µM -1.34112845499213 0.0962259740433997 no 3049 0.0899393750594539 4438 4008346
SGTC_883 0850-0245 24.6 µM -1.34322638940232 0.0958512219181172 no 3050 0.0895993395598059 4459 6823229 YPR165W RHO1
SGTC_407 eburnamonine 100 µM -1.34340043327349 0.0958201809090717 no 3051 0.0895711733392347 4242 3195
SGTC_2304 7443016 91.4 µM -1.3473116321317 0.0951245612169556 no 3052 0.0889399436686573 4336 939854
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.35137083648119 0.094406558623228 no 3053 0.0882883355036728 4430 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_961 1252-1571 372 µM -1.3531374251386 0.0940953309469662 no 3054 0.0880058657124608 4420 6813498
SGTC_2080 5212524 12.4 µM -1.35399406973189 0.0939446849323681 no 3055 0.0878691348483369 4361 260183
SGTC_3243 9134147 49.47 µM -1.35756033076723 0.09331944952224 no 3056 0.0873016188161593 4499 24282180
SGTC_222 nsc-310342 10.666 µM -1.35768453123764 0.0932977302782629 no 3057 0.0872819036323279 4423 432556
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.36067487469313 0.0927759283878575 no 3058 0.0868082290371457 4433 16486 A toxic proline analog.
SGTC_1812 st052057 4.327 µM -1.36122681201591 0.0926798541169694 no 3059 0.0867210117661886 4424 3645418
SGTC_3295 9122362 53.5725 µM -1.36722533619789 0.0916404486028624 no 3060 0.0857773430998623 4407 4730473
SGTC_2725 haloperidol 53.21 µM -1.37051974258675 0.0910732913171475 no 3061 0.0852623584351443 4371 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_787 4152-0075 138 µM -1.37171419535027 0.0908683015088522 no 3062 0.085076213783437 4436 9566539
SGTC_1801 st050089 28.441 µM -1.37874989076167 0.0896677909302479 no 3063 0.0839859406403395 4469 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1913 st060213 96.1 µM -1.38112182483525 0.0892657340530817 no 3064 0.0836207530531467 4419 688959
SGTC_584 0986-0246 15.4 µM -1.38291731524357 0.0889622808734705 no 3065 0.083345110200771 4504 53315 YDR232W HEM1
SGTC_1077 5-fluorocytosine 377 nM -1.38480426025272 0.0886441993728481 no 3066 0.083056163956272 4477 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2241 6772625 37.8075 µM -1.3931075773239 0.0872545732211546 no 3067 0.0817936310502235 4227 2285411
SGTC_1721 st082152 9.2685 µM -1.39656789288288 0.086680287595604 no 3068 0.081271775486981 4366 5296051
SGTC_2644 guaiazulene 100 µM -1.39864866199874 0.0863363188923322 no 3069 0.0809591831006398 4462 3515 A coloring agent.
SGTC_2499 avocadenofuran 51.48 µM -1.39947938764662 0.0861992784006582 no 3070 0.0808346376126022 4393 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2687 chenodiol 100 µM -1.40276170706479 0.0856594024866244 no 3071 0.0803439547116778 4474 5702181 A cholesterol synthesis inhibitor.
SGTC_895 0964-0006 13.7 µM -1.40282039328975 0.0856497728652119 no 3072 0.080335202073749 4426 6738897
SGTC_1653 st012112 65 µM -1.40471800699598 0.0853388365876491 no 3073 0.0800525744934021 4432 720429
SGTC_3302 9125395 16.351 µM -1.40532587803275 0.0852394120243672 no 3074 0.0799621982985697 4392 17599668
SGTC_590 k048-0076 22.4 µM -1.4055795281429 0.0851979501942078 no 3075 0.0799245092856546 4456 6832814
SGTC_2055 5235184 200 µM -1.4064914606284 0.0850490098776498 no 3076 0.079789119278793 4460 2836034
SGTC_2282 7944268 200 µM -1.40980565564637 0.0845093659866529 no 3077 0.0792985380944814 4439 2970414
SGTC_3325 9138760 55.175 µM -1.413745599181 0.0838711795383339 no 3078 0.078718305778039 4397 43844959
SGTC_295 k015-0027 31 µM -1.41523120004362 0.0836314860060867 no 3079 0.0785003597546057 4509 3887424
SGTC_3096 9117468 49.47 µM -1.41525728462531 0.0836272820048054 no 3080 0.0784965370899483 4388 41316311
SGTC_575 k072-0246 11.9 µM -1.41758769187849 0.0832523352294187 no 3081 0.0781555878260671 4532 6796779
SGTC_454 lyso-paf C-16 6.67 µM -1.42078984889252 0.0827391932154515 no 3082 0.0776889313238867 4462 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_476 mead acid 10 µM -1.42688348112936 0.0817692752774479 no 3083 0.0768067415100932 4516 5312531 An omega 9 fatty acid.
SGTC_2244 6635614 200 µM -1.42796716659407 0.081597687306572 no 3084 0.0766506545999917 4393 836499
SGTC_2774 tamoxifen 10.92 µM -1.42896065035319 0.08144062030398 no 3085 0.0765077718083357 4433 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2431 5490079 200 µM -1.43206743982259 0.0809509170174228 no 3086 0.07606226086177 4488 5722345
SGTC_390 dec-rvkr-cmk 16.7 µM -1.43381877750423 0.0806758463069965 no 3087 0.075811992499926 4484 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1448 4255-0083 152 µM -1.43408271769051 0.0806344522954182 no 3088 0.0757743295591773 4477 5399660
SGTC_2541 muurolladie-3-one 83.07 µM -1.43502548116691 0.0804867286981582 no 3089 0.0756399182991311 4409 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1841 st054148 70 µM -1.43712918941459 0.0801578314551927 no 3090 0.0753406443101479 4475 675442
SGTC_1494 4358-1428 177 µM -1.43824983844041 0.0799830425668944 no 3091 0.0751815894401223 4480 1564571
SGTC_395 anisomycin 6.25 µM -1.44378159090254 0.0791244688743608 no 3092 0.0744002109619023 4481 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.44497897720882 0.0789395468337874 no 3093 0.074231895374881 4413 6708514
SGTC_164 4100-3994 89.624 µM -1.44579472609652 0.0788137517552338 no 3094 0.0741173928935846 4447 4615967
SGTC_343 4130-2827 29.8 µM -1.44857579687812 0.0783860295700121 no 3095 0.0737280421722471 4453 1118244
SGTC_823 0417-1665 178 µM -1.4487585378108 0.0783579861863948 no 3096 0.0737025132333118 4476 3429856
SGTC_2212 7123476 200 µM -1.45018928272106 0.0781386872707357 no 3097 0.0735028714342044 4485 1085715
SGTC_3274 9138298 49.47 µM -1.45040709056627 0.0781053434177986 no 3098 0.07347251549211 4444 17015756
SGTC_831 k061-1017 217 µM -1.45231152597582 0.077814256103374 no 3099 0.0732075020409372 4509 1240153
SGTC_1295 1013-0063 9.78 µM -1.45622824604679 0.0772181860453891 no 3100 0.0726647668111628 4484 6826038
SGTC_2825 7998094 58.44 µM -1.4569487340641 0.0771089166050579 no 3101 0.0725652660533239 4442 2987815
SGTC_2690 usnic acid 100 µM -1.45745943592444 0.0770315345893647 no 3102 0.0724948003874212 4471 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2243 6634756 200 µM -1.4608652661709 0.0765169885395591 no 3103 0.072026210170034 4507 885676
SGTC_870 0573-2213 57.6 µM -1.46221092867045 0.0763144106361342 no 3104 0.0718417088749476 4456 3916321
SGTC_2053 5265679 138 µM -1.46690744277654 0.0756105879762132 no 3105 0.0712006177882457 4391 764595
SGTC_1163 k060-0048 49.9 µM -1.4686329567701 0.0753532473083292 no 3106 0.0709661854095108 4490 6809982
SGTC_3315 9136395 68.55 µM -1.46965608651688 0.0752009748128212 no 3107 0.0708274608623116 4463 16876844
SGTC_1633 st005664 67.9 µM -1.47510884008704 0.0743933953511928 no 3108 0.0700916420887461 4461 2063822
SGTC_412 gemfibrozil 100 µM -1.47837510838759 0.0739128261326473 no 3109 0.0696537020591929 4430 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1294 1000-1494 117 µM -1.47963069280009 0.0737287233088999 no 3110 0.0694859154203578 4479 712797 YDL207W GLE1
SGTC_2012 4023501 200 µM -1.48075218730465 0.0735645782704484 no 3111 0.0693363108473251 4466 3477460
SGTC_1757 st041620 31.8375 µM -1.48394251137559 0.0730991616081527 no 3112 0.06891208629364 4505 5289815
SGTC_3247 9135149 49.47 µM -1.48538366077802 0.0728896614963774 no 3113 0.0687211107069035 4540 8934436 YOR116C RPO31
SGTC_2366 9070441 60.58 µM -1.48714908450926 0.0726336483445248 no 3114 0.0684877200302003 4463 6837235
SGTC_2978 9011784 42.97 µM -1.48909485061212 0.0723522812198251 no 3115 0.0682311968004247 4464 2994934
SGTC_99 0109-0120 622.8 µM -1.49413806247302 0.0716268964241263 no 3116 0.0675697686442134 4497 759414
SGTC_1997 st073024 93.8 µM -1.49817581927567 0.0710501625231348 no 3117 0.067043788174551 4541 686268
SGTC_2138 5575593 77.673 µM -1.50090526923395 0.0706623256686198 no 3118 0.0666900325601799 4502 762213
SGTC_573 3702-0553 84.7 µM -1.50351313194386 0.0702932874081296 no 3119 0.0663533865843063 4441 1222756
SGTC_3064 1327-0027 10 µM -1.50537329854889 0.0700309624240144 no 3120 0.0661140649756484 4454 16000455 YPR107C YTH1
SGTC_1524 corynanthine 62.1 µM -1.50601331458884 0.0699408802447931 no 3121 0.066031877858824 4563 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2064 5220758 200 µM -1.50686555048234 0.0698210665919846 no 3122 0.0659225616170693 4526 788518
SGTC_2890 9046729 58.44 µM -1.50762812997715 0.069713991472193 no 3123 0.065824864530596 4478 903329
SGTC_2979 9012552 45.46 µM -1.51413438119135 0.0688055707919208 no 3124 0.0649958801082385 4508 17100905
SGTC_2389 9091542 195.52 µM -1.51735301825618 0.0683595633721844 no 3125 0.0645887894849213 4462 3626624 YOL127W RPL25
SGTC_2957 9076800 11.52 µM -1.51943171940133 0.0680727049262636 no 3126 0.0643269314416941 4482 16459615
SGTC_2776 terbinafine 19.92 µM -1.52298519315857 0.0675844827910277 no 3127 0.0638812049566628 4513 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1694 st024011 44.9 µM -1.52486709226592 0.0673270213279143 no 3128 0.0636461256512292 4556 2787533
SGTC_1966 st070145 16.1 µM -1.52608264556465 0.0671611256687411 no 3129 0.0634946417430506 4481 3748532
SGTC_1261 0712-0010 12.7 µM -1.52665223242343 0.0670834987222212 no 3130 0.0634237556692295 4481 2840123
SGTC_3152 9099253 49.47 µM -1.53059836794228 0.0665475983170359 no 3131 0.0629343426714549 4372 25236131
SGTC_3312 9133330 71.43 µM -1.53530234809889 0.0659131161868793 no 3132 0.0623547888219831 4519 17617324
SGTC_1865 st057639 52.2 µM -1.53601441627512 0.0658174809122113 no 3133 0.0622674223300145 4518 688818
SGTC_654 1124-0271 80.9 µM -1.53640306172931 0.0657653287499242 no 3134 0.0622197781572736 4511 5403748
SGTC_871 0574-0004 149 µM -1.53919951953363 0.0653910172595718 no 3135 0.0618777974471995 4474 9551173
SGTC_1359 1582-0056 520 nM -1.54330729633209 0.0648441822580424 no 3136 0.0613781170760518 4552 3661189
SGTC_2950 9072895 21.46 µM -1.54341475199506 0.0648299253568255 no 3137 0.0613650883297919 4456 17332245
SGTC_1252 0493-0875 34.8 µM -1.54716542509102 0.0643338205207981 no 3138 0.0609116804367156 4510 3960963
SGTC_2529 gangaleoidin 93.61 µM -1.54738830663901 0.0643044329056033 no 3139 0.0608848196071541 4506 4565183
SGTC_1662 st014054 52 µM -1.54876718174778 0.0641228558580482 no 3140 0.0607188486968996 4601 2838777
SGTC_257 daunorubicin 18.5 µM -1.55047334767331 0.0638987315697509 no 3141 0.0605139728567866 4556 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_835 0312-0010 67.2 µM -1.55179205204294 0.0637259225434311 no 3142 0.0603559941529987 4539 1626196
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.55782311893104 0.0629402139552482 no 3143 0.0596375920062902 4604 4620898
SGTC_766 1391-0721 126 µM -1.56111915779458 0.0625140168817851 no 3144 0.0592478193325346 4542 1020919 YIL115C NUP159
SGTC_160 3453-0671 289.699 µM -1.56164715451173 0.0624459533937404 no 3145 0.059185567195197 4509 5322268
SGTC_72 0744-0168 198.391 µM -1.56377428783843 0.0621723320703388 no 3146 0.0589352923146935 4420 677577
SGTC_2705 st078069 42.8 µM -1.57492073939414 0.0607537844550073 no 3147 0.0576373704347779 4538 1530061
SGTC_2135 5326629 150.42 µM -1.58235575146037 0.0598217314615097 no 3148 0.0567841900208058 4489 5020077
SGTC_3235 9132602 49.47 µM -1.58699426914308 0.0592459449929673 no 3149 0.0562569712924883 4520 4912240
SGTC_1969 st069479 40.1 µM -1.58729405259378 0.0592088824335641 no 3150 0.0562230308070752 4537 3895485
SGTC_140 0062-0056 502.533 µM -1.58931378501239 0.0589596543921552 no 3151 0.0559947840362236 4449 3758964
SGTC_1430 4049-0248 69.1 µM -1.59073442720408 0.0587848456412455 no 3152 0.055834677801436 4566 22774488
SGTC_2894 9048625 32.47 µM -1.5940793472722 0.0583748625849392 no 3153 0.0554591320099375 4540 4092861
SGTC_1111 tnp00062 510.699 nM -1.59540627790787 0.0582128456838991 no 3154 0.0553107065287237 4545 676306
SGTC_3310 9130229 44.1445 µM -1.60148319900037 0.057475368969853 no 3155 0.0546349691442831 4556 7761258
SGTC_1861 st057647 17.4 µM -1.6140569306185 0.0559728081268578 no 3156 0.0532575391193417 4579 688668
SGTC_484 loperamide 105 µM -1.61651242158234 0.0556830257144445 no 3157 0.0529917849824011 4654 3955 An opioid-receptor agonist.
SGTC_2643 anethole 100 µM -1.61693927180066 0.0556327724103303 no 3158 0.0529456951015177 4567 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1276 0871-0068 94.2 µM -1.61694052573068 0.0556326248372301 no 3159 0.0529455597531364 4561 3414906
SGTC_956 1185-0240 191 µM -1.61694950894575 0.0556315676254602 no 3160 0.0529445901188314 4533 1416193
SGTC_31 0508-1974 57.237 µM -1.62586717157067 0.0545898681810593 no 3161 0.0519889575326257 4519 6810525
SGTC_2338 7999974 200 µM -1.6264426293308 0.0545231805898694 no 3162 0.0519277642490501 4538 315925
SGTC_1024 4507-0395 26 µM -1.62703343888241 0.0544547809847349 no 3163 0.0518649980377094 4584 4201836
SGTC_837 0091-0265 12.5 µM -1.63042114590905 0.0540638864826715 no 3164 0.0515062592406695 4563 759367
SGTC_460 trequinsin 123 µM -1.64018255879533 0.0529499655867402 no 3165 0.0504836073027253 4646 5537 A vasodilator.
SGTC_37 0566-0070 1.56 µM -1.64105057962489 0.0528517994668305 no 3166 0.0503934581214429 4478 1626686
SGTC_1347 1493-0251 600 nM -1.64211577429664 0.0527315319310915 no 3167 0.0502830065966229 4600 3986378
SGTC_1367 1812-0510 76.9 µM -1.64303586719922 0.0526278222280711 no 3168 0.0501877562637005 4603 1142582 YDR527W RBA50
SGTC_2142 5622915 118.518 µM -1.64332702934993 0.0525950371708036 no 3169 0.0501576444020853 4581 5322196
SGTC_666 0272-0154 136 µM -1.64571417695437 0.0523268535690359 no 3170 0.0499113094199529 4572 6870312
SGTC_650 1328-0195 38 µM -1.64741504987208 0.0521364326574255 no 3171 0.0497363820184573 4578 2780821
SGTC_2459 5811157 9.22 µM -1.6505075233142 0.0517916258686713 no 3172 0.049419587928016 4520 2870684 YBR192W RIM2
SGTC_1691 st019933 84.6 µM -1.65296327252425 0.0515191061728257 no 3173 0.049169169267425 4571 6176082
SGTC_1144 3486-0183 12.5 µM -1.65684619724028 0.0510905379834679 no 3174 0.0487752871541051 4580 6744069
SGTC_2133 5320837 200 µM -1.65936102308886 0.0508144874612419 no 3175 0.0485215327283053 4581 2841355
SGTC_641 4092-0595 30 µM -1.66040243622997 0.0507005206298214 no 3176 0.0484167601869872 4614 786260
SGTC_2048 5246248 200 µM -1.66777145754825 0.0498998990784039 no 3177 0.0476805519789557 4583 677046
SGTC_1017 4239-0030 168 µM -1.66957472500484 0.0497055233211019 no 3178 0.0475017672737438 4596 1149593
SGTC_2240 6690706 185.951 µM -1.67015195943251 0.0496434305187738 no 3179 0.0474446510518855 4472 805876
SGTC_2670 beta-carotene 100 µM -1.67363488525803 0.0492700863940567 no 3180 0.0471011890310347 4573 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2192 5915882 198.485 µM -1.67848275818777 0.0487541658154804 no 3181 0.0466264468081689 4581 2876149
SGTC_2773 thioridazine 9.09 µM -1.68097780922007 0.048490325388476 no 3182 0.046383612466807 4560 5452 An antipsychotic.
SGTC_2471 5466956 24.79 µM -1.68853073291763 0.0476985916806169 no 3183 0.0456546972886143 4586 724419
SGTC_2661 dactinomycin 12.96 µM -1.68892227562708 0.0476578322193 no 3184 0.0456171629024645 4584 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_662 k832-1615 104 µM -1.69270912159949 0.0472650608113078 no 3185 0.0452554240792885 4612 5878478
SGTC_3015 9080845 49.47 µM -1.69450486083504 0.0470797158631944 no 3186 0.0450846944066252 4612 5296973
SGTC_2445 5742597 35.57 µM -1.69551324265895 0.0469758927727527 no 3187 0.0449890501284297 4584 1774255
SGTC_625 k213-0058 121 µM -1.70378442796121 0.0461312041735345 no 3188 0.0442106841113987 4648 3655420
SGTC_3046 9092212 49.47 µM -1.70819077523735 0.0456862148983921 no 3189 0.0438004748155791 4652 25236637
SGTC_2849 9019321 12.99 µM -1.709806337105 0.0455239291772495 no 3190 0.0436508453925814 4593 16489627
SGTC_1334 1486-0610 236 µM -1.71716205567012 0.0447908867163095 no 3191 0.042974783173703 4644 3742339
SGTC_2726 cimetidine 79.27 µM -1.72098852367372 0.0444133308360835 no 3192 0.0426264532113354 4616 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_647 0140-0236 81 µM -1.72345054857541 0.0441717627152364 no 3193 0.0424035402652038 4611 990837
SGTC_684 1140-0066 328 µM -1.72710306875344 0.0438153384379817 no 3194 0.0420745772922183 4610 6813534
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.72738628970197 0.0437877980621396 no 3195 0.0420491556285117 4571 279621
SGTC_18 0111-0177 500 nM -1.73105432134759 0.0434323791547099 no 3196 0.0417210381826936 4669 721752
SGTC_3031 9088762 49.47 µM -1.73247484986849 0.043295362259906 no 3197 0.0415945256186108 4576 205253
SGTC_380 3970-0968 6 µM -1.73617648361645 0.0429399609750372 no 3198 0.0412663170098121 4510 2891601
SGTC_711 k292-0785 179 µM -1.73723306183622 0.04283895039058 no 3199 0.0411730206866988 4549 4146315
SGTC_1953 st076800 12.1 µM -1.7375113488214 0.042812377680781 no 3200 0.041148476297423 4564 297591
SGTC_746 1095-0025 46.6 µM -1.73807362497954 0.0427587284297868 no 3201 0.0410989207979272 4610 6749286
SGTC_1714 st033236 13.627 µM -1.7381023970785 0.0427559846189712 no 3202 0.0410963863074253 4581 2916566
SGTC_2812 7970281 58.44 µM -1.7412062146423 0.0424608281926776 no 3203 0.040823719153956 4614 2233435
SGTC_1265 0819-1001 68.8 µM -1.74681232803069 0.0419318944995272 no 3204 0.0403349487152307 4555 3106768
SGTC_3104 9120930 49.47 µM -1.74727217608188 0.0418887458711762 no 3205 0.0402950685423125 4627 17014836
SGTC_2092 5303694 80.6725 µM -1.75207757103961 0.0414399917109601 no 3206 0.039880235187951 4621 1963699
SGTC_255 tunicamycin 200.472 nM -1.75476154938432 0.0411910476536236 no 3207 0.0396500515440288 4527 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1660 st012960 28.1 µM -1.76212768860001 0.040514049728102 no 3208 0.0390238630375754 4626 24207266
SGTC_2842 9000675 19.48 µM -1.76364570319437 0.0403756626938164 no 3209 0.0388958239626746 4576 2989072
SGTC_1637 st007924 17.4 µM -1.76545070619688 0.0402116127093671 no 3210 0.0387440239262999 4536 683336
SGTC_3161 9100388 49.47 µM -1.76736804871332 0.0400379460629034 no 3211 0.0385833051434423 4668 25236368
SGTC_2994 9053520 71.4286 µM -1.76845454147106 0.0399398059264461 no 3212 0.0384924726997041 4608 4647384
SGTC_582 0987-0078 156 µM -1.77286197277201 0.0395436971679316 no 3213 0.0381257906252114 4647 1625765
SGTC_2339 9000433 200 µM -1.77531102897038 0.0393249780265942 no 3214 0.0379232726697971 4573 2988954
SGTC_398 bronopol 33.3 µM -1.77763149275233 0.0391186523438779 no 3215 0.0377321989672477 4555 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_574 1315-0397 40 µM -1.78006589688145 0.0389031436277748 no 3216 0.0375325884694971 4607 6794277
SGTC_447 ml7 120 µM -1.78153762314756 0.0387733268114859 no 3217 0.0374123321416553 4661 4216 Selective myosin light chain kinase inhibitor.
SGTC_191 3914-0123 66.505 µM -1.78189853127335 0.0387415460601785 no 3218 0.0373828900525731 4680 3144412
SGTC_1789 tunicamycin 25 nM -1.78211629020203 0.0387223809692799 no 3219 0.0373651349155414 4544 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2449 5812982 45.77 µM -1.78588750753034 0.0383916973415022 no 3220 0.0370587370413855 4555 776185
SGTC_2674 ligustilide 100 µM -1.79624948824701 0.0374949332586333 no 3221 0.0362274236504595 4662 5319022 A signalling regulator.
SGTC_1685 st024049 53.0905 µM -1.80362904348947 0.0368667667843572 no 3222 0.0356447399396214 4650 1941139
SGTC_1417 3966-0327 90.4 µM -1.80483771726679 0.0367647062035948 no 3223 0.0355500401721913 4686 651118
SGTC_1253 0550-0034 176 µM -1.80703884950018 0.0365794359007829 no 3224 0.0353781110107112 4612 5969915
SGTC_2251 lansoprazole 556 µM -1.80741680026676 0.0365477005815284 no 3225 0.0353486582038548 4612 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3113 9123498 49.47 µM -1.80870189092145 0.0364399640941093 no 3226 0.0352486645354956 4698 8897275
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.81479839134861 0.0359323952747795 no 3227 0.0347774488597141 4636 688751
SGTC_1781 st038725 66.3 µM -1.81580424697875 0.0358492112281093 no 3228 0.0347002027963006 4625 4270275 YIL048W NEO1
SGTC_2447 5741742 33.78 µM -1.81614928694194 0.0358207128664058 no 3229 0.0346737374572959 4671 1776504
SGTC_1438 4092-1045 4 µM -1.8263188479271 0.0349890659175049 no 3230 0.0339011238929149 4663 1351342
SGTC_2622 2-methoxyxanthone 59.94 µM -1.82632446818413 0.0349886107232248 no 3231 0.0339007008520658 4607 71034 A hepatoprotective.
SGTC_2939 9044578 71.43 µM -1.82751012701553 0.0348926907861989 no 3232 0.0338115524809808 4575 2653634
SGTC_1907 st060210 83.7 µM -1.82753316005221 0.0348908295504565 no 3233 0.0338098225641186 4626 688793
SGTC_2882 9058044 58.44 µM -1.84052399991599 0.0338539875827595 no 3234 0.032845672034622 4650 18076804
SGTC_841 0251-0215 91.2 µM -1.84693016218025 0.0333520991293642 no 3235 0.0323786313118216 4674 3888614
SGTC_2378 9074213 121.43 µM -1.84764325351645 0.0332966131906356 no 3236 0.0323269840623532 4629 657714
SGTC_2931 9014674 55.67 µM -1.84940321200136 0.0331599953726731 no 3237 0.0321998059952822 4595 2996810
SGTC_2659 sanguinarine 24.21 µM -1.85028866715045 0.0330914361953539 no 3238 0.0321359775876853 4610 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1818 st052136 56.3 µM -1.85348660895727 0.0328447973178763 no 3239 0.0319063218748938 4321 674169
SGTC_364 0083-0097 67.7 µM -1.85997820449953 0.0323487970849657 no 3240 0.0314443048342844 4644 5207356
SGTC_2867 9039098 71.43 µM -1.869768360424 0.0316124683676703 no 3241 0.0307579959160846 4628 6463460
SGTC_2286 7945697 125 µM -1.87694242579301 0.0310817384067963 no 3242 0.0302629926286797 4611 1245733
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.8782890882667 0.0309829401127693 no 3243 0.0301708142350414 4641 16623 A steroid.
SGTC_1161 k007-0610 110 µM -1.88336192902927 0.0306131002414132 no 3244 0.029825668020167 4593 5843850
SGTC_3025 9087895 49.47 µM -1.88515276667087 0.0304834139915639 no 3245 0.0297046078523467 4660 17173641
SGTC_1348 1493-0373 93.8 µM -1.88625607780921 0.0304037428318451 no 3246 0.0296302274814053 4661 3010129
SGTC_187 1488-2104 32.728 µM -1.88655749156979 0.0303820074828416 no 3247 0.0296099343974019 4651 2852859
SGTC_727 3032-0951 202 µM -1.89956511044963 0.0294562059247099 no 3248 0.0287451072398898 4687 3652836
SGTC_1227 3909-8010 46.6 µM -1.91051428500145 0.0286951790066846 no 3249 0.028033514449679 4668 15982272
SGTC_1800 st050079 29.0735 µM -1.91507568476783 0.0283829975370141 no 3250 0.0277414261167967 4501 3645560
SGTC_2860 9025725 38.96 µM -1.93137920774404 0.0272902014714141 no 3251 0.0267180872615763 4692 40546248
SGTC_2269 7935389 174.42 µM -1.93308052516389 0.0271782150107038 no 3252 0.0266131393810652 4670 97605
SGTC_2853 9015042 58.44 µM -1.93518784160378 0.0270400361398713 no 3253 0.0264836245964094 4587 6457456
SGTC_1073 triclabendazole 3.09 µM -1.94268550148145 0.026553152383868 no 3254 0.0260270845337562 4692 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_602 3130-1533 38.1 µM -1.96274347793586 0.0252865159227371 no 3255 0.0248379942040528 4687 720941
SGTC_2332 7982454 138.89 µM -1.96834649320647 0.0249418752960844 no 3256 0.0245140919322263 4586 2981748
SGTC_2561 acetosyringone 100 µM -1.98375294931935 0.0240144746179981 no 3257 0.023641693818199 4639 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_469 w7 172 µM -1.99655863195544 0.0232658417262287 no 3258 0.0229365752516686 4747 45115570 A P450 inhibitor.
SGTC_1206 3978-0017 132 µM -2.00902179843132 0.0225561929166055 no 3259 0.0222674110165491 4660 3873677
SGTC_2706 st078239 82.5 µM -2.03455422752433 0.0211592573541186 no 3260 0.0209478734865624 4675 15434492
SGTC_3224 9130643 49.47 µM -2.0423131526049 0.0207495287577665 no 3261 0.0205602391321203 4676 17644395
SGTC_2587 piperic acid 92.2 µM -2.04923822709625 0.0203895272301306 no 3262 0.0202194128766478 4645 5370536
SGTC_533 1222-0222 6.71 µM -2.05187765487308 0.0202537162567253 no 3263 0.0200907769829759 4719 3982874
SGTC_578 3460-0051 92 µM -2.05996732155673 0.0198422330552989 no 3264 0.0197008324776493 4724 2876744
SGTC_14 0354-0009 295 µM -2.07381471718152 0.0191543463665067 no 3265 0.0190482609082592 4764 1713507
SGTC_1339 1486-1321 22.7 µM -2.07758374726056 0.0189706632319458 no 3266 0.0188738572046284 4731 3469382
SGTC_703 3875-0075 71.8 µM -2.08279022803092 0.0187193918942554 no 3267 0.0186351743497859 4726 2850814
SGTC_1234 0326-0494 15.5 µM -2.08575044644037 0.018577795149167 no 3268 0.0185006171211781 4736 1547813
SGTC_8 0354-0001 70 µM -2.08610731821018 0.0185607865790881 no 3269 0.0184844514753509 4703 4993152
SGTC_2436 5633522 8.09 µM -2.10093432987577 0.0178657537002406 no 3270 0.0178233656709483 4686 5724242
SGTC_17 0960-0276 49.807 µM -2.10249866741159 0.0177937352114633 no 3271 0.0177548081298656 4710 6821114
SGTC_2553 4-methylesculetin 85.09 µM -2.11108270070068 0.0174029393846608 no 3272 0.0173826020447712 4689 5319502
SGTC_1192 1488-0095 21.4 µM -2.12007074821139 0.017001629005716 no 3273 0.0170000396946931 4732 915875
SGTC_1443 4112-3303 14 µM -2.12150648105625 0.016938262931812 no 3274 0.0169396015594231 4738 704433
SGTC_3098 9119039 49.47 µM -2.12196217172704 0.0169181932853101 no 3275 0.0169204574044251 4698 17161528
SGTC_2051 5263410 176 µM -2.13992417520055 0.0161431426593094 no 3276 0.0161804475154307 4669 227584
SGTC_2178 5812956 200 µM -2.14506137009468 0.0159271496594596 no 3277 0.0159739702640922 4693 5403383
SGTC_1495 4469-0029 237 µM -2.14859049966985 0.0157802074697748 no 3278 0.0158334377214036 4719 793680
SGTC_813 k007-0158 173 µM -2.14997994412306 0.0157226750700056 no 3279 0.0157784006189596 4704 6523916
SGTC_2935 9038016 29.96 µM -2.18026422413136 0.0145126690715032 no 3280 0.0146189406806976 4676 6463195
SGTC_3167 9103034 49.47 µM -2.18809938259389 0.0142129875687324 no 3281 0.0143311819420073 4770 5127859
SGTC_15 0266-0086 27.098 µM -2.20273115572922 0.0136676027565031 no 3282 0.0138068514875557 4750 1712902 YIL048W NEO1
SGTC_2881 9058953 51.95 µM -2.20369656136585 0.013632261945036 no 3283 0.0137728455778266 4696 17122249
SGTC_230 MPP+ 141.667 µM -2.20681085444253 0.0135187933218526 no 3284 0.0136636382098185 4725 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2993 9054257 71.4286 µM -2.21647621119522 0.0131718145420112 no 3285 0.0133294526662766 4664 6470217 YGL055W OLE1
SGTC_371 0195-0006 7.36 µM -2.21732730028159 0.0131416330629026 no 3286 0.0133003668193755 4610 3928593
SGTC_1979 st071809 45.3 µM -2.21751579177361 0.01313495683211 no 3287 0.0132939325700011 4748 4976333
SGTC_1703 st026983 48.3 µM -2.2186722599576 0.0130940596991288 no 3288 0.0132545147853266 4744 1104023
SGTC_561 1550-0330 72.9 µM -2.22217427378427 0.0129708856716255 no 3289 0.0131357651711097 4719 6812934
SGTC_1680 diphenhydramine 100 µM -2.2345677581221 0.0125429898920928 no 3290 0.0127228697634097 4688 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2845 9003024 42.97 µM -2.24838268752259 0.0120804723224635 no 3291 0.0122758990800128 4708 2990173
SGTC_2419 paclitaxel 166.5 µM -2.26890604651194 0.0114206786510035 no 3292 0.0116370199782595 4695 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_740 k014-0057 261 µM -2.27344699297993 0.0112789984516603 no 3293 0.0114996284953985 4731 4012779
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.29317084078891 0.0106811877883765 no 3294 0.0109190856014454 4737 688662
SGTC_1238 0333-0287 48.8 µM -2.30306140851089 0.0103919407746658 no 3295 0.0106376941170461 4758 7226
SGTC_743 1275-0778 158 µM -2.30549585922489 0.0103218018468027 no 3296 0.0105694091971269 4741 2849257 YMR203W TOM40
SGTC_3053 9095903 49.47 µM -2.30926381007106 0.0102140572667368 no 3297 0.010464473289045 4789 17174018
SGTC_3014 9081533 49.47 µM -2.30965281259137 0.0102029898025767 no 3298 0.0104536916082549 4741 21367265
SGTC_1854 st056233 32.9 µM -2.32131309299856 0.00987606523608881 no 3299 0.0101349760524317 4714 5393174
SGTC_2868 9035608 32.47 µM -2.34184419704455 0.00932261861516051 no 3300 0.00959436170289595 4732 6462614
SGTC_2803 7707263 71.43 µM -2.35140267109051 0.00907434727809579 no 3301 0.00935139091376267 4711 2199229
SGTC_545 4218-0007 221 µM -2.37906088848699 0.00838828029737324 no 3302 0.008678404349172 4749 2840508
SGTC_472 calcifediol 10 µM -2.37972013348186 0.00837249888561289 no 3303 0.00866289555572274 4776 5283731 A vitamin D metabolite.
SGTC_581 0958-0271 211 µM -2.38484711355278 0.00825065320148671 no 3304 0.00854311024770058 4757 4591145
SGTC_559 1550-0661 158 µM -2.38737270335357 0.00819120572438799 no 3305 0.00848463916229298 4759 5830875
SGTC_527 4476-4215 268 µM -2.40127927851073 0.00787056554827724 no 3306 0.00816893102586936 4749 4418754
SGTC_1364 1653-0028 37.6 µM -2.41468616335695 0.00757195237370022 no 3307 0.00787438635973106 4773 5718652
SGTC_655 k060-0012 42 µM -2.41564479752384 0.00755098792283668 no 3308 0.00785368790531731 4755 5994525
SGTC_2330 7979373 200 µM -2.42705268593514 0.00730540422348183 no 3309 0.00761102255569401 4707 1863007
SGTC_2822 7994718 71.43 µM -2.42747638807465 0.00729642016937624 no 3310 0.00760213825595834 4758 1018011
SGTC_3010 9080089 71.4286 µM -2.4301683882025 0.00723956700813032 no 3311 0.00754590470404973 4757 17027233
SGTC_1860 st056228 74.6 µM -2.44218859400339 0.00699044792724602 no 3312 0.00729925905552895 4750 688679
SGTC_553 k007-0256 45.7 µM -2.44680582623402 0.0068967861288577 no 3313 0.00720642316637132 4773 6287000
SGTC_2897 9048598 12.99 µM -2.45376289130138 0.00675775281754 no 3314 0.00706850812996302 4745 6467404
SGTC_1508 1080-0625 72.9 µM -2.45832955825109 0.0066678421715748 no 3315 0.00697925083126719 4721 767111
SGTC_2863 9028737 58.44 µM -2.48560078065244 0.00615260101302396 no 3316 0.00646664805714806 4767 6460917
SGTC_3126 9127922 49.47 µM -2.4912306051196 0.00605073737191715 no 3317 0.00636507325074259 4716 45595682
SGTC_789 1309-1135 70.6 µM -2.50728606367688 0.00576839903887133 no 3318 0.00608311024665339 4754 3092424
SGTC_825 1988-2224 89.6 µM -2.5173103916122 0.00559810590170468 no 3319 0.005912729993066 4756 1180859
SGTC_2185 6113692 200 µM -2.51765260189557 0.00559237208648536 no 3320 0.00590698901057502 4743 874150
SGTC_2429 5902844 64.44 µM -2.53152692510988 0.00536425331504463 no 3321 0.00567835489236724 4759 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3065 9113888 49.47 µM -2.53705770987955 0.00527564873111717 no 3322 0.00558942622138107 4754 16648368
SGTC_1 0258-0098 57.368 µM -2.55208628130692 0.00504142671128613 no 3323 0.00535399987794587 4700 6790032 YDR047W HEM12
SGTC_2649 anisomycin 9.56 µM -2.61078548825098 0.00421284963020684 no 3324 0.00451672686487786 4782 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1724 st037281 8.293 µM -2.63495684699018 0.00390866203050173 no 3325 0.00420739902210322 4741 574124 YDL195W SEC31
SGTC_1519 esterone 74 µM -2.6378561704538 0.00387352947027122 no 3326 0.00417159799397135 4765 698 A steroid.
SGTC_414 piperonyl butoxide 100 µM -2.64270596427281 0.00381539423480931 no 3327 0.00411232126899861 4778 5794 A potent inhibitor of cytochrome P450.
SGTC_2448 5185112 27.17 µM -2.67085334701478 0.00349316840657745 no 3328 0.00378293470290167 4765 5718189
SGTC_2594 a-mangostin 100 µM -2.7140473422088 0.00304606417426302 no 3329 0.0033233333380488 4752 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2425 5628681 7.85 µM -2.77202866387117 0.00252700552265565 no 3330 0.00278540654239576 4778 5714958
SGTC_1716 st033144 30.6155 µM -2.78827249475406 0.00239668449066335 no 3331 0.0026494975751056 4760 674617
SGTC_1516 st013856 110 µM -2.79922429215415 0.00231228561135292 no 3332 0.00256127708060703 4784 5281404 A mutagen and neurotoxin.
SGTC_3155 9099265 49.47 µM -2.86902043874174 0.00183473554456953 no 3333 0.0020587259547082 4774 25236499
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.91244128669993 0.00158483745266725 no 3334 0.0017930780553241 4795 688788
SGTC_2416 tofa 880 nM -2.94759283861337 0.00140570605080872 no 3335 0.00160129285923653 4765 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1783 st039459 87.517 µM -2.95128701045414 0.0013879965986042 no 3336 0.0015822635650889 4796 729761
SGTC_2585 alliin 100 µM -2.95806817075481 0.00135601789339263 no 3337 0.0015478682643871 4773 87310 A garlic compound which reacts with lipids.
SGTC_427 1354-0053 47.3 µM -2.98558173172354 0.00123305809127826 no 3338 0.0014151974490599 4785 6813657
SGTC_653 0203-0016 55.2 µM -2.99286555422174 0.00120226022568959 no 3339 0.00138185734206006 4799 295302
SGTC_611 3453-1652 23.7 µM -2.99310200875248 0.00120127233928682 no 3340 0.00138078714643642 4778 1560575
SGTC_3008 9078912 71.4286 µM -2.99674982336572 0.00118612594361416 no 3341 0.00136437274976999 4789 16648731
SGTC_3037 9091026 49.47 µM -3.00199824468969 0.00116464015604506 no 3342 0.00134106861141502 4733 25236398 YIL048W NEO1
SGTC_724 3910-0327 137 µM -3.05308587027257 0.000973361293822687 yes 3343 0.00113250556998619 4790 2885483
SGTC_103 0844-0104 51.839 µM -3.09047358546349 0.000852148062875355 yes 3344 0.00099918789368015 4695 5375804
SGTC_3048 9093155 49.47 µM -3.10637483008181 0.000804935320785137 yes 3345 0.000946982362624532 4790 25236002
SGTC_416 estradiol valerate 100 µM -3.123458143532 0.00075690452553638 yes 3346 0.000893696429780192 4798 13791 A steroid.
SGTC_2414 st077232 92.9 µM -3.12670569978736 0.000748078023673437 yes 3347 0.000883883951383207 4777 729801
SGTC_1991 st073000 8.92 µM -3.27606010456644 0.000431094923199898 yes 3348 0.000526330780007921 4802 4301969 YIL048W NEO1
SGTC_1701 st028638 40.4 µM -3.33976544463831 0.000338400855512029 yes 3349 0.000419245879790194 4804 3490878
SGTC_2600 tangeritin 87.95 µM -3.40887294695798 0.000259008055651778 yes 3350 0.000326159264351738 4785 68077 A bioactive flavone.
SGTC_1897 st060201 15 µM -3.41591414258326 0.0002519774813604 yes 3351 0.000317841430461228 4804 611878
SGTC_3054 9094397 49.47 µM -3.49182663863177 0.000186677607815462 yes 3352 0.000239864751230524 4791 2598354
SGTC_639 0833-0042 114 µM -3.80701612765487 5.03929923108475e-05 yes 3353 7.03267880859878e-05 4804 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2581 avocatin a 64 µM -4.01544887424648 2.00224187803533e-05 yes 3354 2.96663801421679e-05 4795 6710728 A skin care supplement.
SGTC_1712 st032288 53.4 µM -4.16228972038868 1.0167771729183e-05 yes 3355 1.57536120355104e-05 4771 2883011
SGTC_1232 0279-0259 161 µM -4.46821579604254 2.30364002451744e-06 yes 3356 3.94373579612535e-06 4808 1560000