SGTCid condition conc unit CTM1|YHR109W.score CTM1|YHR109W.strain.pval CTM1|YHR109W.strain.significant CTM1|YHR109W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_996 3970-0799 1.8 µM 10.6967059033441 3.90409374357116e-33 yes 1 5.27304495718534e-27 12 6615648 YGL040C HEM2 SGTC_3013 9080133 71.4286 µM 5.03986109275271 9.28619256421253e-09 yes 2 2.32934928084535e-07 5 17050193 SGTC_1156 4092-0367 4.88 µM 4.26693260509289 9.55354559280105e-07 yes 3 9.90894980565838e-06 13 1357585 SGTC_2998 9066762 71.4286 µM 4.14072256486255 1.90151313653864e-06 yes 4 1.73106749843931e-05 22 4945196 SGTC_106 0092-0003 11.579 µM 4.00374554957576 3.92788731128671e-06 yes 5 3.11737116102105e-05 16 1072148 SGTC_2624 nerol 100 µM 3.85779071365037 8.30137649103902e-06 yes 6 5.72082761038179e-05 10 637566 A natural product oil. SGTC_2767 sibutramine 71.45 µM 3.74811724072412 1.43249926813847e-05 yes 7 8.90834866388516e-05 24 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3000 9075062 71.4286 µM 3.72306671390843 1.61935589396403e-05 yes 8 9.84087441923596e-05 26 17057871 SGTC_792 4534-1957 155 µM 3.71816585446557 1.65852396895933e-05 yes 9 0.000100337253678803 45 1717904 SGTC_2885 9057732 51.95 µM 3.69374471103652 1.86748860053223e-05 yes 10 0.000110487826774363 17 6471414 SGTC_1792 st045773 43.6 µM 3.60074145529633 2.91545211922675e-05 yes 11 0.000158655497247827 42 2919270 SGTC_666 0272-0154 136 µM 3.58263755366644 3.17573109647936e-05 yes 12 0.000170071201544552 70 6870312 SGTC_2345 9052315 157.45 µM 3.56768407748451 3.40715207992616e-05 yes 13 0.000180075180174372 27 6469265 SGTC_3113 9123498 49.47 µM 3.50530363267419 4.55600380614771e-05 yes 14 0.00022804340512959 22 8897275 SGTC_1940 st075990 51.1 µM 3.43192208926171 6.37484809675536e-05 yes 15 0.000299659852704119 37 1084979 SGTC_2288 7946289 167.31 µM 3.42724770550243 6.51131954570562e-05 yes 16 0.000304866299349896 47 1246052 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 3.41475233342272 6.88977095605754e-05 yes 17 0.000319200153332881 42 6708760 SGTC_1628 st004252 77.7 µM 3.41007628092648 7.03665120105224e-05 yes 18 0.000324723561061688 39 692968 SGTC_2917 7979103 53.79 µM 3.40411020833364 7.22833642632154e-05 yes 19 0.000331899826714195 48 2980565 SGTC_61 0978-8327 98.565 µM 3.34242381617697 9.52038797078552e-05 yes 20 0.000415250747049223 49 6150059 YHR072W ERG7 SGTC_786 4544-0069 423 µM 3.28261904347467 0.000123811501068315 yes 21 0.000514237752506959 62 748821 YLR208W SEC13 SGTC_192 3455-0609 60.9 µM 3.26263797971559 0.000135044390759437 yes 22 0.000551902123886514 39 3769639 SGTC_1030 k029-0042 36.7 µM 3.24227591411121 0.00014746917790638 yes 23 0.000592895797601411 60 6080581 SGTC_21 0849-0113 22.993 µM 3.22614087938997 0.000158066664556296 yes 24 0.000627357904205646 57 1560156 SGTC_2508 celastrol 40.54 µM 3.164287029116 0.000205658656781051 yes 25 0.000777316968614936 42 122724 Celastrol is a natural product and antioxidant. SGTC_2428 5615643 7.78 µM 3.14751918258003 0.000220697739273316 yes 26 0.000823311506811865 56 2253075 SGTC_230 MPP+ 141.667 µM 3.13523265908359 0.000232362543128188 yes 27 0.000858589318367876 51 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2739 tacrine 100.86 µM 3.13468416979678 0.000232896455821939 yes 28 0.000860196122499844 44 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3087 9117406 49.47 µM 3.09084465461446 0.000279470478010032 yes 29 0.000997940117321957 48 42546093 SGTC_2400 5203494 178.7 µM 3.08652777475945 0.000284497983302473 yes 30 0.00101254513280537 51 6777674 SGTC_2832 7992762 51.95 µM 3.05663221353528 0.000321694134779833 yes 31 0.00111919369843642 69 2985177 SGTC_3330 9141424 71.43 µM 3.05385371603545 0.000325371650098611 yes 32 0.00112961107206651 52 27261020 SGTC_1912 st060209 90.8 µM 3.02182002775673 0.00037068984464123 yes 33 0.00125629943044597 80 688787 SGTC_2827 7993847 71.43 µM 2.93938907502746 0.000515634309249192 yes 34 0.00164429981025018 65 2985692 SGTC_2475 5812728 15.03 µM 2.90728626763508 0.000585100323194232 yes 35 0.00182289694960731 71 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_454 lyso-paf C-16 6.67 µM 2.86079702445696 0.000701119379726366 yes 36 0.00211288751951209 74 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_890 0929-0006 47.2 µM 2.81607399704554 0.000832411681026878 yes 37 0.00243072340508202 70 1378169 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2.80480985844273 0.000868869462998051 yes 38 0.00251731349775224 95 2374 Ca(2+)-ATPase inhibitor. SGTC_344 k064-0035 6.43 µM 2.76666641126302 0.00100350494509104 no 39 0.00283163363256965 81 5088750 SGTC_542 3381-0244 89.3 µM 2.75926265940333 0.00103175979099497 no 40 0.00289659756729892 99 1112843 SGTC_208 k072-0098 12.366 µM 2.74637361299561 0.00108269509002825 no 41 0.00301290491859355 131 5948901 SGTC_2989 9073649 71.4286 µM 2.74391634259203 0.00109266359583288 no 42 0.00303555037105459 124 21367202 SGTC_76 0433-0009 400.328 µM 2.74082186643584 0.00110533674749544 no 43 0.00306428617391362 48 2841569 SGTC_2506 ethyl hematommate 54.16 µM 2.74039581589872 0.00110709211118311 no 44 0.00306826167610223 72 3940691 An allergen. SGTC_1489 4065-0444 182 µM 2.72129637902994 0.00118845780434258 no 45 0.00325132159783828 79 2877968 SGTC_1492 4158-0558 28.5 µM 2.70531014495036 0.00126073076888309 no 46 0.00341203218864977 80 3967268 SGTC_2282 7944268 200 µM 2.69899277072362 0.00129038317644567 no 47 0.00347748435724536 120 2970414 SGTC_845 0330-0138 4.51 µM 2.69403570223464 0.00131409562563041 no 48 0.00352963013362622 82 9039800 SGTC_1361 1608-0041 5.61 µM 2.68630243203483 0.00135188460089167 no 49 0.00361238305426788 78 X1361 SGTC_2314 7727897 200 µM 2.68533421659208 0.00135668513104722 no 50 0.00362286554484583 97 900724 SGTC_574 1315-0397 40 µM 2.67918041356528 0.00138756229793965 no 51 0.00369013085392428 135 6794277 SGTC_927 2425-1185 123 µM 2.65993197770585 0.0014883325907725 no 52 0.00390782171404604 98 730375 SGTC_2502 avocadyne acetate 18.59 µM 2.6483666440793 0.0015520468455546 no 53 0.00404408763715366 123 3952079 SGTC_1672 st016598 6.51 µM 2.58361519677962 0.00195700069029027 no 54 0.00488854051949169 176 4665860 YNL267W PIK1 SGTC_2397 5161689 200 µM 2.57317735882749 0.00203060295863833 no 55 0.0050384776641823 127 2259942 SGTC_3307 9126885 69.2785 µM 2.56546719885095 0.00208657480696305 no 56 0.0051518481476335 128 24824909 SGTC_120 rhodamine 6G 52.259 µM 2.54761193696796 0.00222160662876211 no 57 0.00542315249614135 148 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2972 9093619 59.92 µM 2.54028301632836 0.00227928839534651 no 58 0.0055381399312184 112 25236256 SGTC_1433 4060-0023 7.6 µM 2.53605555455824 0.00231317399063067 no 59 0.00560544737901588 93 3840627 SGTC_1306 1185-0270 9.02 µM 2.52359128762587 0.00241575430208849 no 60 0.00580814480100745 136 1548076 SGTC_1146 3579-1023 7 µM 2.49639328107317 0.00265401754652088 no 61 0.00627317071891491 116 X1146 SGTC_950 1165-0508 94.1 µM 2.49121514788955 0.00270171469721668 no 62 0.00636535018991663 127 6148369 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.4882397809824 0.00272947040247871 no 63 0.00641885730307874 162 676296 Flavone; oxidizing agent. SGTC_481 bay k-8644 50 µM 2.46797251757022 0.00292548244082616 no 64 0.0067940375736804 116 2303 A calcium channel antagonist. SGTC_3129 9127257 49.47 µM 2.44085613616483 0.00320756385622412 no 65 0.00732624528237079 128 837894 SGTC_2911 7942208 15.64 µM 2.43343685446379 0.00328889405606958 no 66 0.00747812195118791 88 1243384 SGTC_836 0330-0104 1.35 µM 2.431385823344 0.00331170229938576 no 67 0.0075205940685564 116 46494820 SGTC_977 1348-1378 135 µM 2.42318621051066 0.0034043125669946 no 68 0.00769251912836466 131 X977 SGTC_496 calpeptin 138 µM 2.40700455882795 0.00359393228237279 no 69 0.00804198454293032 120 73364 A calpain inhibitor. SGTC_410 α-linolenic acid 100 µM 2.40111190666799 0.00366530408664083 no 70 0.00817266849722969 132 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2802 7925815 54.55 µM 2.39533902470228 0.00373645573781063 no 71 0.0083025018961029 164 1262923 SGTC_272 doxorubicin 8.13 µM 2.38147245826528 0.00391244946645847 no 72 0.00862179008028499 169 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2673 kobusone 100 µM 2.37621505094485 0.00398109424656039 no 73 0.00874563266825134 73 6710676 An epoxy ketone and protein crosslinker. SGTC_261 5-fluorouridine 15.376 µM 2.37348718320539 0.00401713471213475 no 74 0.00881050229584913 146 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1423 4048-0112 5.59 µM 2.35474082967724 0.00427281293549581 no 75 0.00926781420694459 139 X1423 SGTC_3153 9100258 49.47 µM 2.34677833513281 0.00438574545808559 no 76 0.0094682583722992 154 25236848 SGTC_5 0352-0601 109.883 µM 2.34320206170458 0.00443733030401318 no 77 0.00955951274801718 94 762456 SGTC_3066 9117245 49.47 µM 2.34269854215998 0.00444463652612944 no 78 0.00957242240951615 134 17176980 SGTC_712 r015-0009 80.6 µM 2.33212048417773 0.00460063198628164 no 79 0.0098471768605843 118 6813872 YLR060W FRS1 SGTC_157 1348-1695 65.819 µM 2.31735220412542 0.00482659213948103 no 80 0.0102422768523036 226 5380510 SGTC_3245 9134821 49.47 µM 2.30964782952789 0.00494835546473366 no 81 0.010453829658719 157 17014901 SGTC_2285 7945142 200 µM 2.29623201609046 0.00516692942856835 no 82 0.0108313094345482 155 2970608 SGTC_3333 9141820 12.094 µM 2.2843272405262 0.0053680367810346 no 83 0.011176153059991 117 1939433 SGTC_2250 alverine citrate 130 µM 2.28123201522057 0.0054214514310637 no 84 0.0112673606130419 366 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_197 4544-0043 41.561 µM 2.25024787228435 0.00598274384788198 no 85 0.012216607468581 217 896523 SGTC_278 4092-0821 23.9 µM 2.24266558378682 0.00612771357063749 no 86 0.0124591937848328 174 877900 SGTC_592 k241-0073 46.5 µM 2.24247861233168 0.00613132735933085 no 87 0.0124652280411827 152 4230158 SGTC_2001 4023502 57.655 µM 2.22291397693473 0.00652006815018542 no 88 0.0131108005586691 178 108941 YCR052W RSC6 SGTC_649 1123-0311 367 µM 2.20842290140314 0.0068218957138755 no 89 0.0136074034087746 244 693629 YIL048W NEO1 SGTC_3319 9138450 16.7555 µM 2.20204339374596 0.00695863895215409 no 90 0.0138311216936695 161 2029690 SGTC_2460 5552655 174.22 µM 2.20035082751734 0.00699532248352106 no 91 0.0138910068520137 185 5401989 SGTC_579 4491-1009 110 µM 2.19959126674017 0.00701184010461725 no 92 0.0139179536801606 228 1271041 SGTC_2274 7947094 46.08 µM 2.19792468270862 0.00704820278860588 no 93 0.01397723681819 193 2971028 SGTC_2931 9014674 55.67 µM 2.19189932288254 0.00718106049334945 no 94 0.014193388495384 181 2996810 SGTC_217 ketoconazole 989 nM 2.19087114751236 0.00720395081070752 no 95 0.014230559091985 167 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_663 1486-0733 13.9 µM 2.18922415112471 0.00724075208537235 no 96 0.0142902760527288 233 722445 YPR165W RHO1 SGTC_1052 3253-3998 198 µM 2.16024873296688 0.00791585720381561 no 97 0.0153767096986902 209 5450317 SGTC_650 1328-0195 38 µM 2.1562691433482 0.00801277507750428 no 98 0.0155313276185715 194 2780821 SGTC_49 0717-0965 32.132 µM 2.13266366935178 0.0086093853311204 no 99 0.0164761631252184 200 5889349 YGL099W LSG1 SGTC_3290 9121031 71.43 µM 2.13145255558847 0.00864101970510412 no 100 0.0165259385541234 146 17014854 SGTC_3063 1327-0034 4 µM 2.1312110213198 0.00864734077577188 no 101 0.0165358807234745 186 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_298 1391-0729 10 µM 2.13106087417285 0.00865127224427362 no 102 0.0165420637448588 160 3237558 SGTC_44 0929-0055 61.211 µM 2.12401355458456 0.00883757231474725 no 103 0.0168345050815341 178 1379590 SGTC_384 k007-0144 5.16 µM 2.11969716989956 0.00895340678523888 no 104 0.0170157959136224 242 6824886 SGTC_55 0767-0285 6.563 µM 2.11797053663293 0.0090001138511253 no 105 0.0170887815130906 227 3116166 SGTC_3171 9103192 49.47 µM 2.11135793928 0.00918097040934453 no 106 0.0173707787213634 116 13018434 SGTC_3014 9081533 49.47 µM 2.11110580081105 0.00918792899325901 no 107 0.0173816094776157 152 21367265 SGTC_293 4049-0273 38.5 µM 2.10969887016872 0.00922684265126619 no 108 0.017442150942727 149 1380311 SGTC_1260 0700-1617 7.75 µM 2.10858870656524 0.00925764990319063 no 109 0.0174900492688155 232 2853078 SGTC_85 0868-0259 160.055 µM 2.10531798227973 0.00934893698348365 no 110 0.0176318189157062 136 83173 SGTC_124 0136-0217 7.121 µM 2.10424210024717 0.00937913687530202 no 111 0.0176786669111331 237 3976905 SGTC_3122 9126309 49.47 µM 2.09497968132303 0.00964268100978263 no 112 0.018086399369746 152 17591206 SGTC_1902 st060212 70.5 µM 2.06558353074156 0.0105224210597652 no 113 0.0194339104169331 186 688944 SGTC_110 0850-0284 111.64 µM 2.06174330998359 0.0106423618330346 no 114 0.0196160904235953 116 3906265 SGTC_738 1315-0003 72.4 µM 2.05836098201934 0.0107489858304571 no 115 0.019777747145943 210 6251474 SGTC_45 0kpi-0036 14.9 µM 2.05005250687124 0.0110148578143859 no 116 0.0201796536273447 198 2795021 SGTC_1474 0330-0125 5.35 µM 2.04934322401156 0.0110378177323193 no 117 0.0202142824121466 186 X1474 SGTC_517 1365-0151 113 µM 2.04404624228244 0.0112106044032931 no 118 0.0204744895458289 209 768657 SGTC_164 4100-3994 89.624 µM 2.03874787367637 0.0113857839007615 no 119 0.0207375985575105 265 4615967 SGTC_1280 0880-0253 10.1 µM 2.0380792066976 0.0114080601229918 no 120 0.0207710061365565 212 6836607 SGTC_2507 purpurin 79.67 µM 2.02819037613485 0.011741947918987 no 121 0.0212704108759615 248 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2462 5162487 171.77 µM 2.02688248409925 0.0117867366711788 no 122 0.0213372161271337 199 2259986 SGTC_2360 9040895 200 µM 2.01879787321388 0.0120668981299734 no 123 0.0217541161066638 198 4914414 SGTC_1938 st074717 56.4 µM 2.00786005025113 0.0124551121926036 no 124 0.0223290827295588 161 17250979 SGTC_1218 1348-1416 30.7 µM 2.00756931694618 0.0124655770199563 no 125 0.0223445389064343 217 6787668 SGTC_1494 4358-1428 177 µM 2.00754862665398 0.0124663220487486 no 126 0.0223456392028019 218 1564571 SGTC_2879 9041815 71.43 µM 2.00017636842925 0.012734253502658 no 127 0.0227406113255067 100 4942971 SGTC_302 1094-0063 18.9 µM 1.99841798009685 0.012798890017128 no 128 0.022835681966597 157 5440289 SGTC_1188 1403-0014 4.57 µM 1.99307340675787 0.0129970961991182 no 129 0.0231267047555454 296 9614867 SGTC_42 0133-0086 60.653 µM 1.98703512898645 0.0132242162576153 no 130 0.0234592520479049 209 162923 Model of phenazepam hydroxylation. SGTC_495 decylubiquinone 155 µM 1.98416071739553 0.0133335318983979 no 131 0.0236189630893954 233 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1097 itavastatin 7.23 µM 1.98403264470209 0.0133384206903348 no 132 0.0236261004259072 241 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3242 9133940 49.47 µM 1.98243967037842 0.013399357216673 no 133 0.0237150266550695 193 17248444 SGTC_757 1066-0008 322 µM 1.97068525819689 0.0138564786807386 no 134 0.0243799438853149 232 6842497 SGTC_2433 5607874 27.82 µM 1.9697383987792 0.0138938798963083 no 135 0.0244341798846249 248 2252428 SGTC_1428 4049-0204 61.7 µM 1.96868577246374 0.0139355610796328 no 136 0.0244945930501599 218 X1428 SGTC_2635 hydroquinidine 100 µM 1.95724641303703 0.0143955249970629 no 137 0.0251592521998016 219 442912 An experimental heart treatment. SGTC_2179 6298986 200 µM 1.95635372485387 0.0144319626214398 no 138 0.0252117497049105 195 738374 SGTC_1019 4262-0212 3.4 µM 1.95555292980771 0.0144647169000376 no 139 0.02525892120388 307 4677213 SGTC_424 splitomicin 100 mM 1.93715646160856 0.0152349886841875 no 140 0.0263631102646754 237 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_420 mitomycin C 81.9 mM 1.92928153151952 0.0155753352346855 no 141 0.0268479606122406 250 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_725 1497-0963 19 µM 1.92655443749767 0.0156947088256775 no 142 0.0270175907304832 214 3549977 SGTC_2068 5226020 147 µM 1.92636249000844 0.0157031404662132 no 143 0.0270295638273572 296 1810509 SGTC_1682 st012968 530 nM 1.92290065258024 0.0158558762859082 no 144 0.0272462639014002 201 24207270 SGTC_1383 3049-0032 20.7 µM 1.91521888691891 0.0161993501736011 no 145 0.0277322974087178 246 712864 SGTC_2313 7726885 200 µM 1.91341210339974 0.0162810563847193 no 146 0.0278476580697759 265 726423 SGTC_3302 9125395 16.351 µM 1.91020966665018 0.0164267441111232 no 147 0.0280531115129811 222 17599668 SGTC_659 k018-0002 107 µM 1.90335675320881 0.0167422556380313 no 148 0.0284970050181203 246 6797879 YHR007C ERG11 SGTC_2268 7933382 153.85 µM 1.89926502892952 0.0169331013815431 no 149 0.0287648192252479 311 935025 YOR257W CDC31 SGTC_2979 9012552 45.46 µM 1.88456045422536 0.0176343790560707 no 150 0.0297446028168336 184 17100905 SGTC_502 l-744,832 89.3 µM 1.8821589916793 0.0177512304553163 no 151 0.0299072158552129 255 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_795 0685-0265 78 µM 1.88082577975076 0.0178163871772991 no 152 0.0299978110478153 279 302754 SGTC_3303 9125618 40.5795 µM 1.87276742364226 0.0182145737020471 no 153 0.0305502541288988 331 22695467 SGTC_2045 5106652 78.05 µM 1.8709292147069 0.0183064597102723 no 154 0.0306774465066995 219 673349 SGTC_1303 1160-0052 261 µM 1.85683540441399 0.0190241711064517 no 155 0.0316672874873963 257 3562476 SGTC_3334 9142812 21.919 µM 1.8547408878381 0.0191328480210246 no 156 0.0318166184616543 264 45283678 SGTC_141 0443-0274 32.331 µM 1.85399009595626 0.0191719322012333 no 157 0.031870288469226 406 1627241 SGTC_548 1436-0017 110 µM 1.84649287765465 0.0195659534726306 no 158 0.032410336294115 319 9677137 SGTC_2320 7373003 200 µM 1.84396323847862 0.0197004427271732 no 159 0.0325942489168249 260 5415828 SGTC_359 0081-0058 15.9 µM 1.83768650438727 0.0200375412824587 no 160 0.0330543068205688 287 3494159 SGTC_467 ro 31-8220 72.8 µM 1.83532827825362 0.0201654506190639 no 161 0.0332285317730419 338 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1755 st041960 45.185 µM 1.83221170548494 0.0203355540189382 no 162 0.0334599427930747 261 2257073 SGTC_3328 9140624 29.0385 µM 1.82712621553619 0.0206157326465614 no 163 0.0338403972204358 275 4904392 SGTC_3121 9125696 49.47 µM 1.81225106593347 0.0214540969290278 no 164 0.0349737059227195 210 1235365 SGTC_637 1181-0519 7.26 µM 1.80607266201728 0.0218106888761121 no 165 0.0354534952030658 412 6252091 YGR060W ERG25 SGTC_692 k241-0027 77.8 µM 1.79600600046855 0.0224024139830771 no 166 0.0362467813603759 270 3600480 SGTC_2971 9092186 9.93 µM 1.79028602237312 0.0227446305852742 no 167 0.0367039710738322 266 25236400 SGTC_3254 9136651 49.47 µM 1.79016545069693 0.0227518913350435 no 168 0.0367136587228157 304 16454030 SGTC_1376 2910-0861 41.3 µM 1.78590405959307 0.0230097669485761 no 169 0.0370573967858119 315 1112859 SGTC_3170 9103054 49.47 µM 1.78565247571556 0.0230250680491864 no 170 0.0370777723409518 252 16432970 SGTC_2404 5161160 200 µM 1.78560728475013 0.0230278174299253 no 171 0.0370814332870816 330 2831543 SGTC_596 1155-0152 116 µM 1.78372369621912 0.0231426595672757 no 172 0.0372342868507427 358 280313 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.78025157854054 0.0233556179546927 no 173 0.0375173988449176 320 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1847 st056231 15 µM 1.77226745917567 0.0238515774451038 no 174 0.0381750851121636 360 5393180 SGTC_1082 camptothecin 424.86 nM 1.77195080360009 0.0238714286712786 no 175 0.0382013620261839 303 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1015 4130-4525 82 µM 1.77096980556515 0.0239330158851933 no 176 0.0382828614706303 293 1363237 SGTC_1333 1482-0047 286 µM 1.76774588034871 0.0241363557370703 no 177 0.0385516980568282 325 3811116 SGTC_2681 menadione 3.18 µM 1.76589264664094 0.0242538986567399 no 178 0.0387069305513591 300 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_519 k048-0011 62.8 µM 1.76228225388471 0.0244842716517975 no 179 0.0390108103396458 300 6836379 SGTC_506 n9-isopropylolomoucine 153 µM 1.76184509049986 0.02451229055687 no 180 0.039047737018527 275 6610355 SGTC_1810 st050138 53 µM 1.75825802734011 0.0247432123874859 no 181 0.0393518079288284 236 3444541 SGTC_3056 9094900 49.47 µM 1.75723820876153 0.0248091967273547 no 182 0.0394386075589528 317 25236784 SGTC_3296 9122258 64.045 µM 1.74524785719279 0.0255961264923782 no 183 0.0404708670270137 323 4730474 SGTC_1259 0671-0132 43 µM 1.7405857811852 0.0259076914084986 no 184 0.0408781058964338 327 X1259 SGTC_3074 9116018 49.47 µM 1.73955609929112 0.0259769308143339 no 185 0.0409684967704061 264 17027303 SGTC_3324 9138759 60.749 µM 1.73759862798119 0.0261089848994796 no 186 0.0411407808838355 299 45595710 SGTC_2909 7941780 10.49 µM 1.73520900147624 0.0262709533902969 no 187 0.0413518963466588 300 1243215 SGTC_1596 piperlongumine 63 µM 1.73286147864436 0.0264308851695431 no 188 0.041560146237693 316 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2745 rifampicin 24.3 µM 1.72662034500761 0.0268600417477075 no 189 0.0421179348201959 170 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1848 st056003 16.4 µM 1.72597412652727 0.0269048079265397 no 190 0.0421760337985602 313 146492 SGTC_427 1354-0053 47.3 µM 1.72484367667946 0.0269832685559355 no 191 0.0422778240727448 328 6813657 SGTC_2194 5927483 104.545 µM 1.7213354678795 0.0272279781770902 no 192 0.0425949834808917 339 760979 SGTC_2795 7780010 54.55 µM 1.71935100318528 0.0273672193467217 no 193 0.042775239081246 315 953673 SGTC_468 gf-109203x 121 µM 1.71595837922216 0.0276066401323983 no 194 0.0430848302183613 190 2396 A protein kinase C inhibitor. SGTC_391 gliotoxin 8.33 µM 1.71571920004816 0.0276235849179035 no 195 0.0431067244465373 353 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1857 st056007 79.3 µM 1.71432870829901 0.0277222668817643 no 196 0.0432341867652511 262 619834 SGTC_1911 st060208 74.3 µM 1.71314473494448 0.0278065238202286 no 197 0.0433429579132024 337 688783 SGTC_1567 st069303 68.4 µM 1.71172843462663 0.0279075943658486 no 198 0.0434733629716472 355 5581319 SGTC_3213 9129884 49.47 µM 1.70370099889303 0.0284862500160196 no 199 0.0442184807183947 276 17190742 SGTC_1561 5-methoxyflavone 52.9 µM 1.69751152819431 0.0289392017250466 no 200 0.0447999967308712 238 94525 SGTC_1147 3809-1045 12.3 µM 1.69208040074077 0.029341572848923 no 201 0.0453153224231331 331 325925 SGTC_2729 fluphenazine 10.66 µM 1.68651220205358 0.0297589112226381 no 202 0.0458485934295363 350 3372 An atypical antipsychotic. SGTC_2841 9004761 38.96 µM 1.6831050770269 0.0300166966321483 no 203 0.0461773759151441 308 2991039 SGTC_3355 9151058 44.0485 µM 1.67862971977711 0.0303581161240081 no 204 0.0466121153470299 313 17015728 SGTC_939 1165-0479 45.3 µM 1.67644853026145 0.0305256791300496 no 205 0.0468251849154715 355 1377347 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.67600967524721 0.0305594851904044 no 206 0.0468681487443875 313 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2499 avocadenofuran 51.48 µM 1.67504724517214 0.0306337320805681 no 207 0.0469624811845139 365 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1644 st010134 20.9 µM 1.67364990058173 0.0307417963987158 no 208 0.047099712650811 289 3818134 SGTC_2812 7970281 58.44 µM 1.64448603567003 0.0330701853047443 no 209 0.0500379232250311 384 2233435 SGTC_934 2950-0684 338 µM 1.6436413462991 0.0331397315859708 no 210 0.0501251540493922 368 1121253 SGTC_2003 4023581 200 µM 1.64226368759722 0.0332534176105922 no 211 0.0502676845276245 355 16641307 SGTC_2333 9017922 200 µM 1.64107420161269 0.03335183362479 no 212 0.0503910066301101 344 3163164 SGTC_3169 9102970 49.47 µM 1.63414608535452 0.0339298315442942 no 213 0.051114090031574 286 17027839 SGTC_268 camptothecin 39.6153 µM 1.62949497097042 0.0343224671007081 no 214 0.0516041393176724 479 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1254 0550-0035 264 µM 1.62670193578576 0.034560037416059 no 215 0.0519002087157206 386 15121435 SGTC_1879 gemcitabine 100 µM 1.62609086872898 0.0346121933147153 no 216 0.0519651631209752 344 60750 A nucleoside analog which inhibits DNA replication. SGTC_2029 5175081 200 µM 1.61827398248885 0.035285102486096 no 217 0.0528017825518564 397 1380876 SGTC_2667 digitoxin 100 µM 1.61728171191825 0.0353712835726057 no 218 0.0529087425349143 242 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_13 0199-0087 65 µM 1.61607733910056 0.0354761180869381 no 219 0.0530387964957137 362 4589825 SGTC_610 4215-0184 155 µM 1.60677840167471 0.0362941480645358 no 220 0.0540514938989601 386 5605015 SGTC_789 1309-1135 70.6 µM 1.59742731159262 0.0371322724053336 no 221 0.0550852442596647 411 3092424 SGTC_1870 st057514 26.5 µM 1.59725437179644 0.0371479204620097 no 222 0.0551045086074272 363 5393161 SGTC_1282 0886-0010 32.4 µM 1.59540751513729 0.0373153652964636 no 223 0.0553105682834155 400 2836211 YNL267W PIK1 SGTC_3044 9093193 49.47 µM 1.59536578721672 0.037319155659993 no 224 0.0553152310205625 410 25236277 SGTC_2208 7283366 200 µM 1.59043256354193 0.0377694874536391 no 225 0.0558686675514957 360 898663 SGTC_62 0180-0423 3.232 µM 1.58994644474976 0.037814102100639 no 226 0.055923438678447 362 30102 YGL099W LSG1 SGTC_1367 1812-0510 76.9 µM 1.58958031108024 0.0378477332312598 no 227 0.0559647190103095 367 1142582 YDR527W RBA50 SGTC_1401 3807-4679 7.6 µM 1.58915538217657 0.0378867955849656 no 228 0.0560126584370839 337 3291456 SGTC_1802 st050112 57.9 µM 1.58590444136894 0.0381867339608727 no 229 0.05638049408834 363 4662563 SGTC_1770 st043884 66.3 µM 1.58523245725902 0.0382489734508315 no 230 0.056456764306447 376 670149 SGTC_1504 k297-0033 30 µM 1.58305434094551 0.0384512804222275 no 231 0.0567045396137666 302 4388117 SGTC_1662 st014054 52 µM 1.58257667646414 0.0384957630796824 no 232 0.0567589915047739 312 2838777 SGTC_1660 st012960 28.1 µM 1.5710335105348 0.0395835378378333 no 233 0.0580874325848168 404 24207266 SGTC_393 acivicin 6.25 µM 1.57008482664179 0.0396740381283637 no 234 0.0581976890461791 351 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_452 diindolylmethane 8 µM 1.56979043861927 0.0397021556381862 no 235 0.0582319363584769 323 3071 Inhibits expression of several cancer promoting factors. SGTC_2598 perillyl alcohol 100 µM 1.55985793064139 0.0406603613612813 no 236 0.0593967289861821 402 10819 An apoptosis inducer. SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.55365565406541 0.0412681663718362 no 237 0.0601332881667478 383 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_474 dl-dihydrosphingosine 5 µM 1.53973071688962 0.0426596135952501 no 238 0.0618130030796838 409 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2379 9035213 200 µM 1.53722614711446 0.0429138618919177 no 239 0.0621189697371618 431 646551 SGTC_839 0122-0028 230 µM 1.53197905891464 0.0434504834329231 no 240 0.0627638012225725 476 759448 SGTC_793 0488-0545 106 µM 1.53147414605539 0.0435024054998724 no 241 0.0628261256939178 397 292548 SGTC_1000 4048-0884 8.67 µM 1.52863635018575 0.0437951590381001 no 242 0.063177309697637 418 13040088 SGTC_2736 butenafine 14.65 µM 1.52499798269388 0.0441728242854605 no 243 0.0636298004109879 458 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_715 0868-0130 184 µM 1.51574937575613 0.045144663532419 no 244 0.0647913686447381 361 2876258 SGTC_1217 1183-1422 255 µM 1.51466072101048 0.0452601820395865 no 245 0.0649291731973913 408 2849664 SGTC_2259 7964009 200 µM 1.51351876685858 0.045381611644199 no 246 0.0650739689146968 375 313134 SGTC_2424 5537928 59.2 µM 1.50585726638338 0.0462030875529507 no 247 0.0660519093558759 467 5382802 SGTC_2184 6075246 200 µM 1.50186326931789 0.0466360405106312 no 248 0.0665662121738318 408 2267320 SGTC_2895 9054447 58.44 µM 1.49840613652843 0.0470134199447093 no 249 0.067013881512681 376 2697450 SGTC_2992 9074591 71.4286 µM 1.49275675014594 0.0476353713489566 no 250 0.0677504361350945 404 17741321 SGTC_1004 4084-0029 199 µM 1.49102349921187 0.047827503696592 no 251 0.0679776627049745 466 716894 YLR208W SEC13 SGTC_2583 asiatic acid 100 µM 1.48653561050237 0.0483278739690332 no 252 0.068568752448239 390 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3132 9126706 49.47 µM 1.48228706427493 0.0488054090163855 no 253 0.069131964386549 393 850858 SGTC_1679 SEC14.276 6.7 µM 1.47893263914068 0.0491851030787781 no 254 0.0695791594790779 510 1005053 YMR079W SEC14 SGTC_2782 7736369 71.43 µM 1.47135555746705 0.0500514514789318 no 255 0.0705974928560019 474 2950836 YOL077C BRX1 SGTC_2197 6588183 93.1375 µM 1.46879000925704 0.0503475334215237 no 256 0.0709448773619955 375 884136 SGTC_2147 5545932 89.7195 µM 1.46857585797756 0.050372310939226 no 257 0.0709739334888417 405 797404 SGTC_1329 1447-1697 50.6 µM 1.46856944390797 0.0503730532033549 no 258 0.0709748038931984 454 2840515 SGTC_3351 9150312 21.596 µM 1.46278900736774 0.0510455417902473 no 259 0.0717625609619489 461 4904905 SGTC_346 4513-0042 7.16 µM 1.46032815791399 0.051333993720971 no 260 0.0720999534426832 472 2827372 SGTC_2924 9010168 62.78 µM 1.45403601370315 0.0520774341405073 no 261 0.0729681608963086 471 2993929 SGTC_754 3474-0146 171 µM 1.45348290788827 0.0521431925430201 no 262 0.0730448609590399 419 24762078 SGTC_1811 st050069 61.5 µM 1.45246613886324 0.0522642476159285 no 263 0.0731860188824909 369 3877702 SGTC_3216 9129716 49.47 µM 1.45093942683009 0.0524464348016431 no 264 0.0733983639850689 424 8056934 SGTC_2908 7930301 100 µM 1.44779787048509 0.0528229121701466 no 265 0.0738367942582075 489 2223178 SGTC_2116 5511452 16.8835 µM 1.44724208435545 0.0528897390352611 no 266 0.073914566766098 474 870744 SGTC_543 3844-1095 191 µM 1.44214695333763 0.0535054995013843 no 267 0.0746304608128737 481 4230703 SGTC_1223 0764-0573 147 µM 1.4419165502232 0.0535334780166293 no 268 0.0746629583442505 499 1609797 SGTC_1422 4031-0024 15.5 µM 1.43933724779601 0.0538474819549147 no 269 0.0750274971825829 438 782427 SGTC_1807 st050092 58.9 µM 1.43764484188439 0.0540543064108906 no 270 0.0752674253948964 442 5008496 SGTC_572 0960-0087 17.7 µM 1.42859624301364 0.0551708001838039 no 271 0.0765601573093255 533 6796365 SGTC_1637 st007924 17.4 µM 1.42527553880989 0.0555850774180278 no 272 0.0770387840628493 462 683336 SGTC_591 4299-0174 154 µM 1.42152414757432 0.0560560350112244 no 273 0.0775822193094453 444 5509088 SGTC_421 streptovitacin 30 mM 1.42072322635264 0.0561569908689725 no 274 0.0776986187605275 512 91467 include heat shock SGTC_1143 3454-2408 5.08 µM 1.41989317189525 0.0562617701924604 no 275 0.0778193920461688 387 X1143 SGTC_1656 st012921 11 µM 1.41916433606766 0.0563538995265557 no 276 0.0779255554074595 429 6732821 SGTC_2984 9022109 38.96 µM 1.41904118964441 0.0563694777295093 no 277 0.0779435039554889 386 6459207 SGTC_288 1315-0019 35.1 µM 1.41885289168362 0.0563933042603413 no 278 0.0779709543824563 483 6811474 SGTC_2762 leflunomide 42.06 µM 1.4147934835582 0.0569088995122499 no 279 0.0785645276438681 518 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2413 inermin 26.06 µM 1.40968802078001 0.0575626185924286 no 280 0.0793159117301829 503 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1264 0783-0040 158 µM 1.40847850351129 0.0577183509684145 no 281 0.0794947139565812 441 2855798 SGTC_1467 k284-1082 293 µM 1.40415930702075 0.0582771778567571 no 282 0.0801357081905558 483 3334705 SGTC_889 0919-1524 82.7 µM 1.40019638349738 0.0587936399053634 no 283 0.0807272592723575 454 3905452 SGTC_877 0771-0151 33.1 µM 1.39627706881468 0.0593079448620384 no 284 0.081315538197876 522 6166523 SGTC_207 4185-0010 4.486 µM 1.39389526220427 0.059622212198449 no 285 0.0816746176016948 565 3761753 SGTC_867 0518-0118 155 µM 1.38859723711156 0.0603259388637392 no 286 0.0824776289959604 490 6848158 SGTC_166 k072-0058 166.424 µM 1.38560567523022 0.0607261645366224 no 287 0.0829336721699573 490 5846229 SGTC_1392 3455-1037 33.9 µM 1.38185230179216 0.0612312428145318 no 288 0.0835085280379184 492 981132 SGTC_404 fumagillin 50 µM 1.37790332999268 0.0617661794846802 no 289 0.0841165683490118 520 12015870 A methionine aminopeptidase binder. SGTC_1899 st063254 59.6 µM 1.37518520805254 0.0621364973360843 no 290 0.0845370164869828 426 3093813 SGTC_319 1348-1596 45.5 µM 1.36729413871824 0.063221396474744 no 291 0.0857665640734253 518 5380505 SGTC_573 3702-0553 84.7 µM 1.36603299128661 0.063396143385664 no 292 0.0859643042876669 496 1222756 SGTC_1365 1672-3266 55.4 µM 1.36413592614355 0.0636597120765256 no 293 0.086262394782979 529 6415873 SGTC_1916 st067606 49.2 µM 1.36178308323593 0.0639877877283687 no 294 0.0866331759279544 554 19590279 SGTC_2815 7968870 71.43 µM 1.35961448449545 0.0642913356588026 no 295 0.0869759760489475 549 2977326 YHR190W ERG9 SGTC_3194 9111903 49.47 µM 1.35801370061424 0.0645161211906515 no 296 0.0872296684216999 508 17087251 SGTC_1523 st012844 44.7 µM 1.35350703368817 0.0651522366086888 no 297 0.0879468522606512 514 4274103 SGTC_1298 1079-1278 263 µM 1.35242479369339 0.0653057169682241 no 298 0.0881197311636922 516 2840950 SGTC_2114 5491910 81.25 µM 1.35130926798434 0.0654642112250353 no 299 0.0882981922075811 513 2849228 SGTC_1559 coumarin 343 70.1 µM 1.34821521686882 0.0659053763682908 no 300 0.0887945858723658 456 108770 A hepatotoxic, DNA x-linker. SGTC_2095 5432005 200 µM 1.34729280149855 0.0660373437661753 no 301 0.088942974796579 457 783734 SGTC_1305 1181-0477 144 µM 1.34702187717147 0.0660761430266092 no 302 0.0889865934359199 484 6252086 SGTC_1754 st042065 16.137 µM 1.34122278647922 0.066910876304293 no 303 0.0899240651471516 667 1126236 YIL048W NEO1 SGTC_3131 9127911 49.47 µM 1.34112181929111 0.0669254816513169 no 304 0.0899404521004556 512 45595681 SGTC_1966 st070145 16.1 µM 1.34099200069258 0.0669442641052884 no 305 0.0899615248924517 513 3748532 SGTC_2228 7354201 200 µM 1.33789656711211 0.0673933273441096 no 306 0.0904650781871035 485 753451 SGTC_2883 9059145 45.46 µM 1.33508975635662 0.0678025288046496 no 307 0.0909234858557888 479 16476510 SGTC_1250 0485-0349 40.2 µM 1.33506714927518 0.0678058324362103 no 308 0.0909271850219202 519 6842794 YDL195W SEC31 SGTC_2723 salbutamol 83.58 µM 1.3346552568988 0.0678660451097111 no 309 0.0909946019637923 410 9884233 β2-adrenoceptor agonist SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.33182169158494 0.0682813909121821 no 310 0.0914593941239437 456 6857784 SGTC_1062 mesoridazine 14.2 µM 1.3314130763131 0.0683414474921769 no 311 0.0915265645526235 541 4078 A neuroleptic. SGTC_576 1073-0113 22.7 µM 1.33002052721526 0.0685464247723984 no 312 0.0917557540488433 705 5439563 SGTC_974 1326-0144 138 µM 1.32243074392368 0.0696719542461116 no 313 0.0930123784876821 555 5411856 SGTC_2166 5933061 31.504 µM 1.3185506191854 0.0702528279387791 no 314 0.0936596958542453 521 2877375 SGTC_1617 st002906 78 µM 1.31720475798351 0.0704551776198433 no 315 0.0938849997429265 560 5150859 SGTC_2012 4023501 200 µM 1.31336627760451 0.0710347530624739 no 316 0.0945297775362101 501 3477460 SGTC_2540 epiandrosterone 100 µM 1.30957992597008 0.0716100380053596 no 317 0.0951689915086803 683 441302 A steroid. SGTC_2317 5986382 200 µM 1.30937263532556 0.0716416359198732 no 318 0.0952040781086925 546 877883 SGTC_2676 harmalol 100 µM 1.30918566376427 0.0716701457117938 no 319 0.0952357336131114 561 5459187 A monoamine oxidase inhibitor SGTC_185 k048-0037 25.491 µM 1.30701208436645 0.0720022164091676 no 320 0.0956043036873536 552 6827589 SGTC_914 3820-6779 408 µM 1.30567443330641 0.0722071629423764 no 321 0.0958316479806492 519 2893481 SGTC_2358 9037157 4 µM 1.30527221257091 0.0722688760402348 no 322 0.0959000862529224 545 2388925 SGTC_1326 1431-2094 10.8 µM 1.30309359217405 0.072603846392693 no 323 0.0962714054989329 570 616278 SGTC_783 0848-0141 92.7 µM 1.30120505061067 0.0728951771927694 no 324 0.0965941384786505 516 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2695 st077686 51.995 µM 1.30069840423283 0.0729734856735816 no 325 0.0966808543611612 499 2876092 SGTC_172 1112-0046 2.638 µM 1.30002789152201 0.0730772207028898 no 326 0.0967957049414062 482 2802135 YIL048W NEO1 SGTC_2683 piperine 63.03 µM 1.29944278119489 0.0731678352998559 no 327 0.0968960089767774 521 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_684 1140-0066 328 µM 1.29865435189936 0.0732900733478996 no 328 0.0970312881547746 610 6813534 SGTC_1287 0971-0001 34.6 µM 1.29735978921426 0.0734911210567303 no 329 0.0972537106176048 602 4665869 SGTC_1343 1487-0095 224 µM 1.29714719646948 0.0735241773369162 no 330 0.0972902725095727 517 4560101 YGL055W OLE1 SGTC_488 nitrendipine 139 µM 1.29288150739941 0.0741898593446762 no 331 0.0980260221548935 586 4507 Dihydropyridine L-type calcium channel blocker. SGTC_599 1935-0052 86.5 µM 1.29234965262178 0.0742731796622515 no 332 0.098118042015836 572 9557311 SGTC_2266 7929956 200 µM 1.29198169644589 0.0743308654489053 no 333 0.0981817416773721 571 2967153 SGTC_1647 st011722 22.4 µM 1.28995540058364 0.0746491481061258 no 334 0.0985330718313717 519 2854783 SGTC_3278 9139605 49.47 µM 1.28688249778363 0.0751338109628162 no 335 0.0990676232703913 546 7958859 SGTC_2369 9071472 200 µM 1.28486246345165 0.0754537185283731 no 336 0.0994201749942986 559 17296037 SGTC_2638 epoxomicin 18 µM 1.28388633499713 0.0756086769681872 no 337 0.0995908646254561 596 9915668 A protesome inhibitor. SGTC_731 3966-0296 387 µM 1.28355289924542 0.075661664747079 no 338 0.0996492195434966 547 660956 SGTC_941 3237-0776 460 µM 1.28308762376892 0.0757356510452981 no 339 0.0997306896106499 533 760008 SGTC_897 1000-0139 31.4 µM 1.28145710904147 0.0759953641572432 no 340 0.100016577962083 547 6151020 SGTC_2028 5153890 36.43 µM 1.28067113846328 0.0761207977902957 no 341 0.10015460066674 549 2830968 YPR165W RHO1 SGTC_248 streptozotocin 5.23457 mM 1.2785669753715 0.0764573784433906 no 342 0.100524792820356 578 5300 DNA alkylating agent. SGTC_2100 5377183 190 µM 1.27715072111665 0.076684558315426 no 343 0.100774520418983 614 2844202 SGTC_2478 5763493 32.33 µM 1.27353353510744 0.0772671169214899 no 344 0.101414390203194 582 1365576 YLR208W SEC13 SGTC_3174 9107204 49.47 µM 1.27059153718798 0.07774340882746 no 345 0.101936999601024 559 3938802 SGTC_1077 5-fluorocytosine 377 nM 1.27037086933506 0.0777792232860991 no 346 0.101976277377198 544 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2938 9059746 27.26 µM 1.26819821791695 0.0781325141705003 no 347 0.102363586644027 535 6471769 SGTC_1404 3909-7820 48.3 µM 1.26694153903083 0.0783374153519911 no 348 0.102588097154592 558 23741373 SGTC_734 2023-0417 80 µM 1.26491789139989 0.0786682266000589 no 349 0.102950381528802 577 3935732 SGTC_1212 0520-0165 585 µM 1.26395934246034 0.0788252922609785 no 350 0.103122310185029 565 5403258 SGTC_1386 3228-0095 33.8 µM 1.26365375656903 0.0788754147864527 no 351 0.103177164939311 545 870181 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.26265890581355 0.0790387585321312 no 352 0.103355894220292 602 2724 A muscle relaxant with antifungal properties. SGTC_1648 st011736 69.8 µM 1.26214021819322 0.0791240229777007 no 353 0.103449167806404 566 2855514 SGTC_1164 k060-0068 93.7 µM 1.25710957078046 0.0799546028076601 no 354 0.104356980990554 621 5963676 SGTC_3188 9110789 49.47 µM 1.25679095440905 0.0800074287963108 no 355 0.104414671187927 596 849217 SGTC_2709 st078560 56 µM 1.25263905406953 0.0806982204335928 no 356 0.105168547588739 575 17250903 SGTC_2670 beta-carotene 100 µM 1.2462918455187 0.081762959252501 no 357 0.106328635249194 489 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2382 9035899 200 µM 1.24224685547264 0.0824470063883581 no 358 0.107072748394973 598 6462679 SGTC_116 0155-0182 31.788 µM 1.23989121138602 0.0828473490153174 no 359 0.107507817502088 720 771486 SGTC_2855 9016525 58.44 µM 1.23954375894392 0.0829065222551423 no 360 0.107572096923923 593 43811474 SGTC_736 0958-0254 92.6 µM 1.23699497301186 0.0833415682580046 no 361 0.108044474454834 640 6812352 SGTC_3051 9093778 49.47 µM 1.23291830092301 0.0840409695612336 no 362 0.108803123404043 510 17217378 SGTC_2038 4100038 30.985 µM 1.22484052655951 0.0854398094737341 no 363 0.11031765608736 620 3596803 SGTC_1587 estradiol valerate 56.1 µM 1.22112609529552 0.0860888657440585 no 364 0.111019140385473 624 13791 A steroid. SGTC_179 1273-0063 6.77 µM 1.22054033403006 0.0861915569627774 no 365 0.111130054583821 553 3108139 SGTC_3089 9117425 49.47 µM 1.21879546171287 0.0864979977056017 no 366 0.11146091722218 566 9401657 SGTC_2571 chrysanthemic acid 100 µM 1.21827474751566 0.0865896050228176 no 367 0.111559791477753 562 2743 An insecticide. SGTC_713 1488-1073 324 µM 1.21822228119448 0.0865988392482026 no 368 0.111569757367213 598 3312542 SGTC_82 0054-0107 293.755 µM 1.21716244065234 0.0867855319224135 no 369 0.111771208712636 591 3104697 SGTC_1740 st038286 13.222 µM 1.21678598189814 0.0868519180924617 no 370 0.111842827457883 613 716786 SGTC_103 0844-0104 51.839 µM 1.2148576237874 0.0871925671438498 no 371 0.112210199257334 722 5375804 SGTC_2470 5664817 21.68 µM 1.21353277745654 0.0874271819188158 no 372 0.112463095238833 600 2859561 SGTC_2411 st077133 39.94 µM 1.21223277799999 0.0876578543139161 no 373 0.112711643816281 679 1403142 YNL221C POP1 SGTC_2887 9044784 58.44 µM 1.21169604749283 0.0877532243090611 no 374 0.112814376336893 627 6465546 SGTC_3055 9094636 49.47 µM 1.21075654830692 0.0879203473224947 no 375 0.112994361399864 572 25236176 SGTC_64 000l-0018 272.079 µM 1.20716187059703 0.0885619791220531 no 376 0.113684905713431 721 6811119 SGTC_1671 st016596 74.5 µM 1.20549990807685 0.0888598075016057 no 377 0.114005186745639 663 2829167 SGTC_2178 5812956 200 µM 1.20429002996413 0.089077089663514 no 378 0.114238749419444 587 5403383 SGTC_1600 coumarin 106 71.1 µM 1.20321618265936 0.0892702730590941 no 379 0.11444633710025 643 100336 A hepatotoxic, DNA x-linker. SGTC_2453 5731132 22.18 µM 1.19797612796113 0.0902174238229187 no 380 0.115463155304933 672 1362040 SGTC_2811 7967822 32.47 µM 1.19611828663742 0.0905550186940381 no 381 0.115825201217786 622 2232244 SGTC_547 1120-0019 610 nM 1.19420649360724 0.0909033954408752 no 382 0.116198601804579 622 3676939 SGTC_1406 3909-7906 11.9 µM 1.19071339589688 0.0915424921372454 no 383 0.11688305861008 639 X1406 SGTC_613 3914-0030 117 µM 1.18701462208347 0.0922228425495549 no 384 0.117610926475687 370 1145395 SGTC_2456 5770359 74.46 µM 1.18453684681504 0.0926806920131832 no 385 0.118100309709535 650 3118787 SGTC_3110 9122132 49.47 µM 1.18189247354176 0.0931711780741108 no 386 0.118624184384501 648 918317 SGTC_2646 retinol 96.75 µM 1.18162374258809 0.0932211302467284 no 387 0.118677514226499 620 445354 A vitamin A analog and teratogen. SGTC_821 1114-0266 29.2 µM 1.1800865354567 0.0935072493645065 no 388 0.118982899622943 622 3123235 SGTC_3224 9130643 49.47 µM 1.170098933848 0.0953820450845577 no 389 0.120980578743088 620 17644395 SGTC_2137 5261020 140 µM 1.16651596537517 0.0960613122259388 no 390 0.121702948713298 632 763655 SGTC_2017 5132927 60.65 µM 1.16207222649252 0.0969086989110552 no 391 0.122603063935861 642 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3284 9108171 64.8615 µM 1.16150440187886 0.0970173728961725 no 392 0.122718417054467 612 8687505 SGTC_1689 st020265 53.493 µM 1.15875786342178 0.0975442863561157 no 393 0.123277448714211 670 5758320 YPR016C TIF6 SGTC_22 0964-0034 14.468 µM 1.15813255288568 0.0976645426776429 no 394 0.123404973686475 686 138402 SGTC_2975 9084847 53.72 µM 1.15298393984202 0.0986588304676808 no 395 0.124458488244908 679 27211724 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.15223923460135 0.0988032573153733 no 396 0.124611389638741 609 5282362 SGTC_2055 5235184 200 µM 1.15163460816883 0.0989206312723218 no 397 0.124735626875415 649 2836034 SGTC_97 0535-0701 19.132 µM 1.1490038760052 0.0994325134761627 no 398 0.125277191203938 628 2832013 YGL099W LSG1 SGTC_694 1315-0438 43.2 µM 1.14866594100157 0.0994984082191381 no 399 0.125346877537603 562 6793154 SGTC_1779 st039427 55 µM 1.14221836883223 0.100761755046218 no 400 0.126681631256019 761 1124498 SGTC_3273 9137859 49.47 µM 1.14117857307647 0.100966584721386 no 401 0.126897809520391 653 2377234 SGTC_790 1575-0012 79.1 µM 1.13979060863308 0.101240473036697 no 402 0.127186773621716 701 378741 YLR208W SEC13 SGTC_331 k048-0133 24.5 µM 1.12895819284157 0.103396661764528 no 403 0.129457735165588 622 6813582 SGTC_378 3970-0959 8.33 µM 1.12884534801933 0.103419297584561 no 404 0.129481539447667 688 6615653 SGTC_521 r062-0005 13.8 µM 1.12720877003382 0.103747987242382 no 405 0.12982711169156 661 2832033 SGTC_1244 0416-0015 52.5 µM 1.12531056761568 0.104130169918126 no 406 0.130228726607069 665 96201 SGTC_1013 4112-3890 241 µM 1.12397740973385 0.104399196414325 no 407 0.130511304768491 690 705171 SGTC_1773 st048542 73.5835 µM 1.123915644216 0.104411672671415 no 408 0.130524406950925 684 3237138 SGTC_9 0092-0002 10.449 µM 1.12261698349183 0.104674244409579 no 409 0.130800099606781 698 759368 SGTC_1965 Pectolinarigenin 58.4 µM 1.12199451623663 0.104800268335051 no 410 0.13093238575922 689 5320438 An anti-inflammatory. SGTC_286 k060-0067 22.9 µM 1.12076126786776 0.105050274620747 no 411 0.13119474749232 666 5985051 SGTC_655 k060-0012 42 µM 1.11965727957467 0.105274443006433 no 412 0.131429918206556 677 5994525 SGTC_1957 st077035 62.4 µM 1.11619926814782 0.105978842816941 no 413 0.132168423854052 704 705593 SGTC_1199 1638-0010 4.46 µM 1.11610680971498 0.105997723313404 no 414 0.132188208809689 712 3111136 SGTC_227 fluconazole 33.516 µM 1.11480428373276 0.106263964289924 no 415 0.132467150193836 737 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_220 paclitaxel 373.376 µM 1.11420164112259 0.106387309896805 no 416 0.132596345773621 624 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2576 guaiol 23.12 µM 1.11049383547589 0.107148478615633 no 417 0.133393141520105 728 227829 SGTC_2085 5307070 144.047 µM 1.1096901672976 0.107313978797053 no 418 0.13356628070668 638 2840351 SGTC_1839 st053978 48 µM 1.10862548047201 0.107533514486251 no 419 0.13379589063675 679 3788398 SGTC_1959 st077091 55.8 µM 1.10862113718526 0.107534410723174 no 420 0.13379682786355 706 821356 YKL052C ASK1 SGTC_2394 5221648 200 µM 1.10196018136999 0.108915239716609 no 421 0.135239491490559 796 788586 SGTC_2238 6671620 73.2395 µM 1.10093313108193 0.109129278373175 no 422 0.135462880632685 669 729941 SGTC_466 geldanamycin 89.2 µM 1.0998863524056 0.109347739315846 no 423 0.135690820869799 575 5288382 HSP90 inhibitor. SGTC_983 1491-0821 12.2 µM 1.09958254943615 0.109411201260804 no 424 0.135757024341277 707 46495113 SGTC_2787 5284540 71.43 µM 1.09950019438964 0.109428409110319 no 425 0.135774974619032 695 736958 SGTC_2560 caryophyllene 100 µM 1.09932442275488 0.109465142588175 no 426 0.13581329160814 760 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_959 1222-0044 107 µM 1.09582150525932 0.110199044283362 no 427 0.136578447685863 707 6083612 SGTC_362 0310-0100 9.03 µM 1.09406705354497 0.110567945802043 no 428 0.136962785418617 675 790235 SGTC_3147 9097027 49.47 µM 1.09342605370236 0.110702946804492 no 429 0.137103389768902 746 25236841 SGTC_1249 0481-0015 10.2 µM 1.09286813193897 0.110820546845775 no 430 0.137225851052727 647 4227577 SGTC_749 1000-0129 128 µM 1.09264358672913 0.110867902257122 no 431 0.137275158782052 756 708470 SGTC_2732 terfenadine 20 µM 1.09138189282818 0.111134256496702 no 432 0.137552438284224 663 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.0893188046902 0.111570778496187 no 433 0.138006661523719 662 279621 SGTC_3145 9085516 49.47 µM 1.08727020053194 0.112005448469969 no 434 0.138458707087076 684 25236195 SGTC_2946 9065502 71.43 µM 1.08500084968821 0.112488368129758 no 435 0.138960639469149 545 16489101 SGTC_812 4251-0442 148 µM 1.08420584921554 0.112657896156704 no 436 0.139136769400296 703 5723007 SGTC_143 4032-1194 15.74 µM 1.08396736869517 0.11270878593806 no 437 0.139189633645206 805 1806963 SGTC_1074 carmofur 3.8 µM 1.08395856498983 0.112710664890488 no 438 0.139191585434044 783 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1605 st000082 49.1 µM 1.07992622624366 0.113573629392667 no 439 0.140087516728113 746 1114022 SGTC_2724 maprotiline 69.64 µM 1.07588196511266 0.114443866833295 no 440 0.140990024325097 747 4011 A tricyclic antidepressant. SGTC_398 bronopol 33.3 µM 1.07504810077631 0.114623885088799 no 441 0.141176596782593 731 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_329 k048-0121 21.3 µM 1.07152970134479 0.115385671210976 no 442 0.14196566160159 706 6832902 SGTC_3291 9121177 71.43 µM 1.06904420604528 0.115925982357196 no 443 0.142524875283187 632 17015612 SGTC_2452 5863136 48.41 µM 1.06504877457308 0.116798292496666 no 444 0.143426929213661 721 2184096 SGTC_2381 9035592 200 µM 1.06406313869644 0.117014197002329 no 445 0.1436500489971 666 4749657 SGTC_3260 9137109 49.47 µM 1.06378729651616 0.117074671120917 no 446 0.143712533709452 621 17478346 SGTC_3277 9138724 49.47 µM 1.06371842280361 0.117089774068165 no 447 0.143728138078908 644 15943418 SGTC_773 4358-1457 44.6 µM 1.05908159294114 0.118109736275786 no 448 0.144781311071654 805 1186886 SGTC_569 4130-2812 160 µM 1.05894881569668 0.118139035506965 no 449 0.144811545392648 619 743552 SGTC_1458 k015-0034 6.33 µM 1.05753540977962 0.118451242701504 no 450 0.14513365146445 703 3598957 SGTC_1712 st032288 53.4 µM 1.05734492204293 0.118493364084799 no 451 0.14517709923036 862 2883011 SGTC_472 calcifediol 10 µM 1.05726298135724 0.118511486381276 no 452 0.145195791523064 691 5283731 A vitamin D metabolite. SGTC_1583 clindamycin 39.6 µM 1.05652305104225 0.11867522073776 no 453 0.145364657617196 669 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1864 st057645 30.4 µM 1.05633633962037 0.118716562132637 no 454 0.14540728956168 729 688666 SGTC_77 0828-0286 12.516 µM 1.05298771685154 0.119459737787026 no 455 0.146173310840792 752 745345 SGTC_2619 obliquin 87.91 µM 1.05260748600373 0.1195443312717 no 456 0.146260462397585 823 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3099 9120367 49.47 µM 1.05216678499628 0.119642430975759 no 457 0.146361517787756 752 24824940 SGTC_674 0498-0004 451 µM 1.05173062916289 0.119739574816851 no 458 0.146461577088934 722 4231473 SGTC_2715 st079500 56.4 µM 1.05161651575533 0.119765000173298 no 459 0.146487763629825 697 28246688 SGTC_1197 1601-0112 267 µM 1.05115011628226 0.119868957186551 no 460 0.146594824819209 765 7350313 SGTC_2134 5324836 1.464 µM 1.04964364804816 0.120205172420845 no 461 0.146940990651387 679 699272 SGTC_1687 st020778 55.3625 µM 1.048377121039 0.120488351004921 no 462 0.147232445142848 865 4259299 SGTC_1958 st076513 41.9 µM 1.04607735923866 0.121003747478015 no 463 0.147762658705265 746 732122 YGL099W LSG1 SGTC_1741 st038134 10.228 µM 1.04176480141342 0.121974406218254 no 464 0.148760368448319 810 1272587 SGTC_2132 5317594 122.667 µM 1.03948161551035 0.122490507771992 no 465 0.149290401955854 701 794577 SGTC_876 0720-0963 56.8 µM 1.03722434985655 0.123002254629051 no 466 0.149815656240547 810 765861 SGTC_3195 9113082 49.47 µM 1.03681441954005 0.123095350905436 no 467 0.14991117704302 741 17018038 SGTC_1050 3232-1156 69.3 µM 1.03437717821198 0.123649874699552 no 468 0.150479934585015 736 700529 SGTC_2083 5306046 65.942 µM 1.03092568608868 0.124438150787787 no 469 0.151287835099747 759 539837 SGTC_1397 3532-0190 20.1 µM 1.02944279052334 0.124777901796884 no 470 0.151635825052664 700 5322280 SGTC_2311 7694451 200 µM 1.02838604241884 0.125020412001855 no 471 0.151884135725954 759 2163142 SGTC_1986 st071812 45 µM 1.02603960669573 0.125560065614251 no 472 0.152436457681017 728 11838594 SGTC_2449 5812982 45.77 µM 1.02584278564653 0.125605406004686 no 473 0.152482847440501 734 776185 SGTC_3327 9140648 26.9345 µM 1.02376739476194 0.126084195763447 no 474 0.152972577104334 756 8029710 SGTC_1281 0884-0031 11.8 µM 1.02295486417977 0.126271991563383 no 475 0.153164593549549 804 1548255 SGTC_3276 9139060 49.47 µM 1.01982082383204 0.126998170983779 no 476 0.153906722649791 731 4870619 SGTC_3220 9131269 49.47 µM 1.01781003319864 0.127465613312488 no 477 0.154384121501291 770 17722206 SGTC_1721 st082152 9.2685 µM 1.01720617070855 0.12760622468579 no 478 0.154527680573737 731 5296051 SGTC_1068 loratadine 26.9 µM 1.01470760971737 0.128189168876395 no 479 0.155122612812948 751 3957 A H1 histamine antagonist. SGTC_353 1988-1175 58.3 µM 1.01411148581804 0.128328524557996 no 480 0.155264778989695 724 2788357 SGTC_2020 4017018 200 µM 1.01399114965531 0.128356668256734 no 481 0.15529348770115 775 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1697 st025554 27.742 µM 1.01376206502935 0.128410257416626 no 482 0.155348150318326 749 1269519 SGTC_2202 7226349 200 µM 1.01215819219396 0.128785882179011 no 483 0.155731211172261 770 844334 SGTC_1065 prochlorperazine maleate 2.48 µM 1.01110632852462 0.129032640661178 no 484 0.155982770874443 815 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2078 5212016 200 µM 1.00638366182095 0.130144578464676 no 485 0.157115524913337 771 1899708 SGTC_1967 st070177 51.4 µM 1.00601587057196 0.130231451286328 no 486 0.157203967888966 772 5729214 SGTC_1817 st052116 64.4 µM 1.00575175260171 0.130293861077041 no 487 0.157267500682484 779 4361398 SGTC_2539 epi(13)torulosol 80 µM 1.00188183494977 0.131210676836251 no 488 0.158200333410781 745 6708597 SGTC_3196 9111891 49.47 µM 1.00100002228473 0.131420207405258 no 489 0.158413398805419 780 18891510 SGTC_1340 1486-1359 257 µM 0.999388559841092 0.131803709139182 no 490 0.15880324978118 801 4309068 SGTC_1829 berberine 14.4 µM 0.997503024655983 0.132253415070358 no 491 0.159260203193697 804 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3019 9081971 49.47 µM 0.996659115068046 0.132455032344983 no 492 0.159465000656051 853 16451803 SGTC_3211 9128781 49.47 µM 0.996657075014564 0.132455519987823 no 493 0.15946549593894 754 17194361 SGTC_3226 9131256 49.47 µM 0.994174352541427 0.133049892974209 no 494 0.160068996066136 725 17178073 SGTC_1748 st037455 53.6035 µM 0.99276309484675 0.13338857049078 no 495 0.160412709400997 785 580690 SGTC_1529 apigenin 74 µM 0.990275972894607 0.133986879384205 no 496 0.16101962361174 813 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1922 5578187 25 µM 0.989462836439953 0.134182889122079 no 497 0.161218372007819 768 1350412 SGTC_1133 3473-0247 50 µM 0.98654440801541 0.134888009343089 no 498 0.161933017367477 776 711311 SGTC_1476 4112-3294 3.34 µM 0.985476039867612 0.135146771757973 no 499 0.162195147495528 821 704369 SGTC_2374 9071832 200 µM 0.984014708409662 0.135501262093347 no 500 0.162554140533255 805 17381698 SGTC_3138 9097216 49.47 µM 0.982138994111781 0.135957206599441 no 501 0.163015688617099 876 25237486 SGTC_2467 5474540 200 µM 0.979081543761696 0.136702654195558 no 502 0.163769845060246 833 5413519 SGTC_2793 7325131 81.82 µM 0.977904606188499 0.136990350947163 no 503 0.164060753385018 794 4176441 SGTC_1251 0490-5699 265 µM 0.97739073234789 0.13711609461443 no 504 0.164187874688069 892 3883818 SGTC_1426 4048-4480 71.7 µM 0.976670084470578 0.137292568173834 no 505 0.164366255006853 837 14224343 SGTC_535 2293-4129 48.2 µM 0.974375853195008 0.137855416359511 no 506 0.164934977175622 915 396118 YIL048W NEO1 SGTC_1283 0922-0125 16.4 µM 0.974077814941282 0.137928650031277 no 507 0.165008951964993 881 3360884 SGTC_483 fpl-64176 144 µM 0.973117119179899 0.138164891886076 no 508 0.165247548317922 779 3423 SGTC_449 xestospongin c 11.1929 µM 0.972293540197311 0.138367635277809 no 509 0.165452268297469 851 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1539 benzyladenosine 56 µM 0.966210555887733 0.139871384402034 no 510 0.166969415943191 815 92208 A nucleotide analog. SGTC_3020 9089140 49.47 µM 0.964565706576184 0.1402799014664 no 511 0.167381191482031 820 17217859 SGTC_2366 9070441 60.58 µM 0.959757280140006 0.141478772342484 no 512 0.168588693662081 851 6837235 SGTC_1664 st014217 9.02 µM 0.956722798804693 0.142238913870007 no 513 0.169353593766794 933 3982782 SGTC_3350 9150499 3.57 µM 0.954555697132214 0.142783464231583 no 514 0.169901215172487 884 4910996 YPR165W RHO1 SGTC_1380 2291-0730 164 µM 0.954453082298461 0.142809284234981 no 515 0.169927173816391 784 2999191 SGTC_758 0868-0029 16 µM 0.954349490542445 0.142835353253215 no 516 0.169953382172897 875 762687 SGTC_327 1273-0057 3.96 µM 0.95316597263807 0.143133415571795 no 517 0.170252992018442 815 3108138 SGTC_987 1497-1013 404 µM 0.952936793647241 0.143191181533777 no 518 0.170311048207284 850 1676435 SGTC_1189 1431-2119 7.28 µM 0.948750875534686 0.144249038339052 no 519 0.171373665978858 884 3107275 SGTC_1342 1486-1464 234 µM 0.947042299129062 0.144682336581688 no 520 0.171808612583562 863 3253938 SGTC_2303 7774051 200 µM 0.945387025175068 0.14510295247621 no 521 0.172230661898241 816 2953184 SGTC_408 cantharidin 100 µM 0.945010996549148 0.145198618397726 no 522 0.172326630987656 878 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2686 alizarin 95.37 µM 0.944602180460498 0.145302673962928 no 523 0.17243100671118 801 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.943640275092049 0.145547704661083 no 524 0.172676751878171 728 88881 An O-methylated flavonoid and antioxidant. SGTC_2534 helenine 20.12 µM 0.94201114810877 0.145963333360395 no 525 0.173093466176267 805 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2597 laccaic acid a 100 µM 0.940853552824526 0.146259147407732 no 526 0.173389956364749 852 5491415 A textile dye. SGTC_2850 9015429 58.44 µM 0.940010198319006 0.146474913110766 no 527 0.173606164775085 815 6457570 SGTC_654 1124-0271 80.9 µM 0.936096206437949 0.147479073414431 no 528 0.174611828030582 876 5403748 SGTC_1118 chelidonine 707.474 nM 0.935725194427848 0.14757449773475 no 529 0.174707347632376 929 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1707 st032323 6.317 µM 0.932049722648115 0.148522063583315 no 530 0.175655414733064 856 3132057 YMR211W DML1 SGTC_2978 9011784 42.97 µM 0.930773953359463 0.148851916105288 no 531 0.175985252886861 984 2994934 SGTC_1619 st003326 88.7 µM 0.929698912377953 0.149130249728072 no 532 0.176263498886158 850 2849032 SGTC_1352 1496-0991 99 µM 0.925987397861001 0.150093850035049 no 533 0.177226264725354 875 3000039 SGTC_1007 4101-0031 70 µM 0.925779257250972 0.150148011087664 no 534 0.177280354510812 907 1146276 SGTC_838 0109-0203 71.4 µM 0.922236812908869 0.151071801497154 no 535 0.178202532476116 893 759422 SGTC_2755 lomerizine 42.69 µM 0.921480456471419 0.15126953128597 no 536 0.178399820070714 897 3949 A calcium channel blocker. SGTC_2593 nobiletin 86.24 µM 0.917998620228303 0.15218198648215 no 537 0.179309794108717 819 72344 An anti-infammatory. SGTC_171 k064-0041 9.68 µM 0.917250849935647 0.152378423998458 no 538 0.179505603114008 805 53325 SGTC_2896 9052656 71.43 µM 0.916491036375205 0.152578197564691 no 539 0.179704703348283 922 6469436 SGTC_16 erodoxin 22.806 µM 0.916278402688992 0.152634135266307 no 540 0.179760446351049 943 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_707 0865-0008 204 µM 0.914908137396876 0.15299493827318 no 541 0.180119928880804 950 723043 SGTC_2964 9083345 53.42 µM 0.912459483886779 0.153641097344557 no 542 0.18076344426728 839 17741579 SGTC_2679 rapamycin 1 nM 0.911544320819867 0.153883056892418 no 543 0.181004322125 958 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.909219257717396 0.154498912898939 no 544 0.181617200425736 891 616764 SGTC_397 arbidol 50 µM 0.908686502374867 0.154640256707853 no 545 0.181757815486973 950 131410 A RNA synthesis inhibitor. SGTC_830 4076-0286 57.8 µM 0.908389011541523 0.154719220326145 no 546 0.181836364629664 1001 6866659 SGTC_2008 4012253 172 µM 0.901164114278898 0.15664511951154 no 547 0.183750533986086 925 603940 SGTC_2706 st078239 82.5 µM 0.893805709946887 0.158622758974854 no 548 0.185712926797356 932 15434492 SGTC_1625 st003711 30.1 µM 0.893696898503546 0.158652125367219 no 549 0.185742042635041 919 24207034 YER133W GLC7 SGTC_1978 st071761 42 µM 0.891478808448041 0.159251527777154 no 550 0.186336177688499 877 5147680 SGTC_351 caspofungin 25 nM 0.888146141531316 0.160154910880359 no 551 0.18723107268446 1024 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_458 nppb 133 µM 0.887703708698495 0.160275092173695 no 552 0.187350075218988 902 4549 A chloride channel blocker. SGTC_1610 st001799 48.1 µM 0.88723509517836 0.160402449382916 no 553 0.187476170632819 846 621897 SGTC_1852 st056254 31.4 µM 0.886904931277032 0.160492219211875 no 554 0.187565043248812 912 442583 SGTC_1466 k213-0079 57.5 µM 0.884675467851049 0.161099257550967 no 555 0.188165845292899 946 3657981 SGTC_2031 5180455 200 µM 0.88127199733327 0.162028840127784 no 556 0.189085309378572 911 29949 SGTC_2150 5556613 200 µM 0.880721021617871 0.16217965486027 no 557 0.189234417959797 963 743190 SGTC_2699 st077704 54.6 µM 0.880405172773991 0.162266151161618 no 558 0.189319927635767 910 645852 SGTC_100 0086-0128 49.5915 µM 0.879715418877773 0.162455147045298 no 559 0.189506747201515 975 93297 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.879703846362333 0.162458319191596 no 560 0.189509882579939 897 279621 SGTC_356 1634-0012 32.5 µM 0.879123866761084 0.16261734923718 no 561 0.189667059182575 976 735457 SGTC_2711 st079103 59.1 µM 0.878646548014584 0.16274830568799 no 562 0.189796474449837 929 54693780 SGTC_878 0828-0289 13.7 µM 0.876427297449999 0.163358076474079 no 563 0.190398891951075 927 745350 YLR208W SEC13 SGTC_2109 5483026 200 µM 0.875246080193228 0.163683237200344 no 564 0.190720012713656 940 759335 SGTC_1081 sertraline 6 µM 0.875070140661558 0.163731705054037 no 565 0.190767871320512 965 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1034 k072-0165 12.7 µM 0.874623933571587 0.163854668032852 no 566 0.190889280436609 967 5835461 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.872659999587355 0.164396588934247 no 567 0.191424213252532 959 4213774 SGTC_1640 st009078 66.4 µM 0.869527863678862 0.165263260598505 no 568 0.192279237218593 895 690618 SGTC_66 0109-0187 42.4 µM 0.868775448022695 0.165471895997792 no 569 0.192484982327264 856 759417 SGTC_1835 st008666 49.2 µM 0.867078354189212 0.165943104036003 no 570 0.192949539874739 848 690455 SGTC_396 dithiazanine 1.25 µM 0.866777599181102 0.166026700795004 no 571 0.193031939048877 917 10578 An antihelmenthic. SGTC_370 0180-0345 38.7 µM 0.865527599068887 0.166374437763962 no 572 0.193374637259726 879 3989527 SGTC_3225 9130819 49.47 µM 0.865287463120792 0.166441294887895 no 573 0.19344051506443 964 4547121 SGTC_1327 1436-0082 2.18 µM 0.864665604867659 0.166614509316399 no 574 0.193611176457937 943 15992205 SGTC_963 1269-2853 151 µM 0.86352204436642 0.166933343966543 no 575 0.193925252241277 925 3668223 SGTC_1185 1319-0113 81.3 µM 0.862926262463335 0.16709960897504 no 576 0.194089005071666 922 4672763 SGTC_126 0417-1624 672.48 µM 0.862744801123543 0.16715027064333 no 577 0.194138897113916 1102 41912 YDL195W SEC31 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.861023240141153 0.167631400838374 no 578 0.194612621698985 961 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2586 curcumin 80 µM 0.860751645053693 0.167707385773026 no 579 0.194687421122632 1012 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1698 5-fluorocytosine 1.055 µM 0.860284570709184 0.167838112362386 no 580 0.194816097969498 985 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2568 diosmetin 100 µM 0.860126799411634 0.167882284827471 no 581 0.194859574925767 970 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2936 9038235 15.59 µM 0.859340707834642 0.168102484566464 no 582 0.195076285714182 979 4749415 SGTC_818 4072-2707 53.5 µM 0.857659270622652 0.168574111862604 no 583 0.195540318175757 962 882871 SGTC_1107 amlodipine 47 µM 0.857400353493223 0.16864681118246 no 584 0.195611832003334 908 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.857263063611393 0.168685367911351 no 585 0.195649758396279 1028 5106787 A p450 inhibitor. SGTC_685 1278-0033 54.9 µM 0.853561667438146 0.169727009430519 no 586 0.196673952690125 976 3590572 SGTC_1126 isoteolin 1.0172 µM 0.852180224259633 0.170116828060551 no 587 0.197057035443929 950 133323 SGTC_2945 9067681 61.76 µM 0.852037978616692 0.170156999800392 no 588 0.197096506669865 977 16456930 SGTC_2054 5233173 129 µM 0.851780381446149 0.170229763555342 no 589 0.197167998548004 968 6889 SGTC_435 c-PAF 6.7 µM 0.851475537117491 0.170315899018965 no 590 0.197252623369652 964 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_597 k018-0003 82.8 µM 0.851428561479571 0.170329174729432 no 591 0.197265665765834 1066 6786234 SGTC_802 4112-3352 742 µM 0.851072032391193 0.170429954455522 no 592 0.197364670113221 1011 704594 SGTC_1930 st074634 34.3 µM 0.849634795676627 0.170836603912289 no 593 0.197764080161618 1009 684253 YOR116C RPO31 SGTC_1475 4092-1048 11.7 µM 0.848498455063461 0.171158557451852 no 594 0.198080216248159 985 2881759 SGTC_3028 9087778 49.47 µM 0.848016276084877 0.171295287916819 no 595 0.198214453202587 994 17217395 SGTC_2142 5622915 118.518 µM 0.847573635697243 0.17142086796676 no 596 0.198337731082706 946 5322196 SGTC_2718 lomofungin 53.02 µM 0.847466897912804 0.171451158996235 no 597 0.198367465088867 948 5351222 A RNA synthesis inhibitor. SGTC_3098 9119039 49.47 µM 0.846277214079089 0.171789009938821 no 598 0.198699058043136 978 17161528 SGTC_2485 5633444 17.78 µM 0.845960900917746 0.171878909260236 no 599 0.198787278200253 941 5724239 SGTC_1709 st033179 39.1045 µM 0.845860028358453 0.171907584553358 no 600 0.198815416655095 1002 573381 SGTC_626 0214-0009 33 µM 0.845544525636761 0.171997293013501 no 601 0.198903441808123 1012 3437874 SGTC_1113 artemisinin 1.17947 µM 0.843961025296531 0.172447988854821 no 602 0.199345592560159 1008 2240 An anti-malaria and mitochondrial poison. SGTC_1733 st037357 54.9 µM 0.842818072711653 0.172773763623757 no 603 0.199665099394806 959 1272339 YGL099W LSG1 SGTC_2189 6047310 154.431 µM 0.842212279391732 0.172946591309664 no 604 0.199834570835828 947 711535 SGTC_641 4092-0595 30 µM 0.841805497475488 0.173062704528702 no 605 0.199948417124116 992 786260 SGTC_3326 9140064 16.379 µM 0.840201809797171 0.17352095026764 no 606 0.200397621928358 1008 1868434 SGTC_89 0302-0250 142.109 µM 0.839962056511484 0.173589524863501 no 607 0.200464830652134 1087 4203518 YLR208W SEC13 SGTC_211 3455-0679 143.504 µM 0.838898895009004 0.173893819662244 no 608 0.200763023968466 1006 748649 SGTC_1898 st060199 18.6 µM 0.838859244123141 0.17390517497378 no 609 0.200774150313359 993 688866 SGTC_2493 resveratrol 26.09 µM 0.838076097806799 0.174129550834026 no 610 0.200993983053794 929 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2423 st077119 87.2 µM 0.837975253781103 0.174158456586004 no 611 0.201022300921501 989 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2340 7987427 183.45 µM 0.837921344267823 0.174173910363791 no 612 0.201037440157009 926 2239331 SGTC_643 k048-0106 28.4 µM 0.837556171224213 0.174278614333625 no 613 0.2011400085357 977 6763920 SGTC_256 clotrimazole 625 nM 0.836727952491255 0.174516232919184 no 614 0.201372751650116 970 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2903 5923464 63.88 µM 0.833069565224895 0.175568296089254 no 615 0.202402748497848 1016 2876576 SGTC_1812 st052057 4.327 µM 0.831129387848545 0.176127871494896 no 616 0.202950269777625 1052 3645418 SGTC_1070 indatraline 8.81 µM 0.827030704865042 0.177313698191583 no 617 0.204109829153883 978 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1245 0418-0076 17.2 µM 0.825231091569402 0.177835949429046 no 618 0.204620202433343 981 6790114 SGTC_357 1325-0123 420 µM 0.823875617260945 0.178229950614817 no 619 0.205005118014435 1004 1098503 SGTC_442 cape 100 µM 0.822638618717971 0.178589993709259 no 620 0.205356765249372 974 5281787 SGTC_2115 tiliquinol 12.7705 µM 0.818002179398862 0.179943556313503 no 621 0.206677971411819 984 71208 A bioactive hydroxyquinoline. SGTC_1653 st012112 65 µM 0.816752170465956 0.180309583814917 no 622 0.207035035290886 998 720429 SGTC_1984 st072354 53.1 µM 0.81640315171198 0.180411866833783 no 623 0.20713479731429 1004 5762938 SGTC_967 1306-0166 352 µM 0.811995804314216 0.181706609406041 no 624 0.208397019504202 1020 4437607 SGTC_2680 butyl paraben 22.24 µM 0.811918290854891 0.181729432365725 no 625 0.208419259136439 1041 7184 An antifungal and steroid mimetic. SGTC_1554 st069299 38.7 µM 0.811083961738894 0.181975204653084 no 626 0.208658727751796 1052 24207999 SGTC_2409 alverine citrate 63.97 µM 0.809576321324199 0.182419844277604 no 627 0.209091860835515 1005 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2796 7949634 45.45 µM 0.804737777343685 0.183851427148566 no 628 0.210485507373585 968 2971588 SGTC_83 0170-0301 39.027 µM 0.804685743094653 0.183866860484496 no 629 0.210500524376626 989 3089716 SGTC_648 0375-0473 33.3 µM 0.803745207115089 0.184145962142551 no 630 0.210772069979694 1035 1713139 SGTC_852 0418-0143 439 µM 0.803576433805321 0.184196073084473 no 631 0.210820818876198 1092 5369229 SGTC_2111 5486399 200 µM 0.801646158019335 0.184769799985351 no 632 0.211378834594719 1069 689674 SGTC_661 1304-0007 33.6 µM 0.799157295024138 0.185511190716197 no 633 0.212099605375937 996 3117130 SGTC_2892 9047358 58.44 µM 0.798860863748561 0.185599615524634 no 634 0.212185547072294 987 6466771 SGTC_1834 st055981 52.8 µM 0.798817669751549 0.185612502383316 no 635 0.212198071624662 1061 471719 YDL150W RPC53 SGTC_218 alverine citrate 93.75 µM 0.79719378864038 0.186097387409666 no 636 0.212669246431813 1014 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2863 9028737 58.44 µM 0.796345241791821 0.186351072479097 no 637 0.212915698104977 1038 6460917 SGTC_2016 5121758 140 µM 0.795584598710525 0.186578659484343 no 638 0.213136760637904 1101 2795203 SGTC_2155 5570423 76 µM 0.79454667961498 0.186889485939394 no 639 0.213438622614887 976 797402 SGTC_990 3985-0011 41.3 µM 0.793628701521875 0.187164660426115 no 640 0.213705809230806 983 5399565 YGL099W LSG1 SGTC_1905 st060207 84.5 µM 0.791708623521432 0.187741035526113 no 641 0.214265296455947 1028 1948547 SGTC_1575 cyproterone acetate 48 µM 0.791584897763858 0.187778213477432 no 642 0.214301377825512 1018 9880 An androgen receptor antagonist and liver toxin. SGTC_960 1222-0186 7.7 µM 0.791323339499385 0.187856823237206 no 643 0.214377666059729 1039 3126296 SGTC_2728 chlorpromazine 9.18 µM 0.788810373565052 0.188613115171431 no 644 0.21511142278058 1020 2726 A thorazine and dopamine antagonist. SGTC_708 3448-5400 146 µM 0.78869359976233 0.188648304517368 no 645 0.215145554780961 1073 3462195 SGTC_1954 st077032 68.9 µM 0.788084807233143 0.188831827399468 no 646 0.215323550629633 1013 698907 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.786108778080662 0.189428266808748 no 647 0.215901881043636 1031 75037 A free radical scavenger. SGTC_2299 7976368 114.88 µM 0.784953654378533 0.1897774626557 no 648 0.216240371032968 1046 2979718 SGTC_2605 digitonin 300 nM 0.78471417639492 0.189849906766116 no 649 0.216310584548024 1145 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1484 3473-2379 286 µM 0.784649936802896 0.18986934267668 no 650 0.216329421457602 1210 671917 SGTC_908 3448-7491 47.7 µM 0.784222166600785 0.189998797224341 no 651 0.216454880286066 1100 1203031 SGTC_514 4466-0038 2.65 nM 0.784151070947493 0.190020317901061 no 652 0.216475735695085 1056 5722064 SGTC_2188 6126565 140.678 µM 0.78404849258887 0.190051371042844 no 653 0.216505828382934 1022 874518 SGTC_98 0074-0023 107.663 µM 0.78233308104144 0.190571132903679 no 654 0.217009425116144 1081 3563821 SGTC_1616 st002734 56.1 µM 0.781801585608541 0.190732350501339 no 655 0.217165594530928 1057 4026101 SGTC_2581 avocatin a 64 µM 0.779089147252319 0.191556412596861 no 656 0.217963601342919 1055 6710728 A skin care supplement. SGTC_1460 k062-0059 9.15 µM 0.777647625096299 0.19199524562318 no 657 0.218388388249731 1076 1373085 SGTC_2302 7771753 200 µM 0.777271968751181 0.192109705172125 no 658 0.218499164715203 1077 2203047 SGTC_2657 nystatin 74.44 µM 0.777238134210574 0.192120016341029 no 659 0.218509143695909 1108 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1072 oxiconazole 14.9 nM 0.776607292998974 0.192312328935708 no 660 0.218695248726324 1068 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1032 k061-1018 98.7 µM 0.77362113190254 0.193224259891912 no 661 0.219577435878812 1158 4005393 SGTC_2429 5902844 64.44 µM 0.773346077225477 0.193308390209816 no 662 0.219658796625222 1104 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2281 7943571 200 µM 0.773218603427842 0.193347387895564 no 663 0.219696509046321 1144 1244024 SGTC_2448 5185112 27.17 µM 0.772956611843175 0.19342755328506 no 664 0.219774029484866 1031 5718189 SGTC_1045 1348-1485 165 µM 0.770704342302728 0.19411754923576 no 665 0.2204410987659 1178 6810614 SGTC_262 fenpropimorph 62.5 µM 0.770220681759353 0.194265916800515 no 666 0.220584498851572 1001 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1177 0983-0204 23.6 µM 0.769762539865061 0.194406519940656 no 667 0.220720382211733 1113 766818 SGTC_231 b-estradiol 524 µM 0.7691868591848 0.194583283383607 no 668 0.220891195134204 1045 450 A steroid. SGTC_901 1112-0062 60.1 µM 0.768736846838599 0.194721528300691 no 669 0.221024773099361 1118 1908457 SGTC_1362 1611-0397 101 µM 0.767955046428575 0.194961841367789 no 670 0.221256946193135 1100 27816 SGTC_339 3091-4833 71.4 µM 0.767422482843188 0.195125646194265 no 671 0.221415182691959 1081 3240077 SGTC_1752 st044819 83.042 µM 0.767039385277973 0.195243530279623 no 672 0.221529049510541 1066 441209 YML126C ERG13 SGTC_273 hydroxyurea 18.1 mM 0.765686210662786 0.195660265921021 no 673 0.221931516928288 1174 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_981 1488-1094 54.9 µM 0.764756337978104 0.195946950543351 no 674 0.22220832581575 1077 3449522 SGTC_2737 bleomycin 30.5 nM 0.764414656795029 0.196052356637521 no 675 0.222310088559525 1141 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_896 0964-0007 44.5 µM 0.762935628896857 0.196509022222989 no 676 0.22275089324722 1114 6756758 SGTC_603 3794-0023 45.9 µM 0.762634939442891 0.196601942067149 no 677 0.222840570647376 1090 3802260 SGTC_313 3474-0040 5.03 µM 0.762604267688346 0.196611421829083 no 678 0.222849719324759 1094 1043375 YIL048W NEO1 SGTC_1766 st045414 44.774 µM 0.761177293603731 0.197052764772559 no 679 0.223275589312653 1157 253960 SGTC_2000 st075254 36.4 µM 0.756896903357771 0.1983802214112 no 680 0.224555815369411 1057 17234175 SGTC_2587 piperic acid 92.2 µM 0.75658957035456 0.198475740283614 no 681 0.224647895866476 1053 5370536 SGTC_1743 st037606 46.3785 µM 0.755784860628103 0.198725974883652 no 682 0.224889097569859 1092 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.75468066756921 0.19906964701974 no 683 0.22522030447287 1105 5357218 A potent inhibitor of glutathione S-transferases. SGTC_469 w7 172 µM 0.75464923983782 0.199079433912887 no 684 0.225229735382366 1160 45115570 A P450 inhibitor. SGTC_2838 9002687 71.43 µM 0.754582880200077 0.199100099884697 no 685 0.225249649477397 1049 6457060 SGTC_928 2764-0428 58.7 µM 0.753352401419691 0.19948353441245 no 686 0.225619088781833 1099 662578 SGTC_251 melphalan 456.522 µM 0.753351765330861 0.199483732741571 no 687 0.225619279849952 1195 460612 A DNA alkylator. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.752812983270726 0.199651764752826 no 688 0.225781151878907 1178 23665772 A membrane-active detergent. SGTC_1588 farnesol 29.9 µM 0.750800158701361 0.200280265019185 no 689 0.226386466953125 1089 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3048 9093155 49.47 µM 0.746915016699001 0.201496749306906 no 690 0.227557430415232 1095 25236002 SGTC_1457 k015-0032 57.3 µM 0.745750473296834 0.201862242398658 no 691 0.227909081524895 1078 4302660 SGTC_1038 k292-0204 154 µM 0.744626285390514 0.202215446140448 no 692 0.228248836527043 1103 4454212 SGTC_315 k915-0449 187 µM 0.743417080429217 0.202595773442611 no 693 0.228614603217778 1149 20970215 YNL149C PGA2 SGTC_1550 gossypolone 36.6 µM 0.74182094921538 0.203098453540889 no 694 0.229097913042671 1147 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_532 1548-0774 215 µM 0.740354447204529 0.20356096441336 no 695 0.229542475785088 1167 5932993 SGTC_2122 5258151 111.688 µM 0.739958122495381 0.20368606651771 no 696 0.229662702547784 1115 2173356 SGTC_688 0527-0193 473 µM 0.739744343490233 0.203753566080785 no 697 0.229727567946746 1090 4007154 SGTC_1708 st033234 31.827 µM 0.738214277251772 0.204237065355319 no 698 0.230192124136179 1176 674664 SGTC_1720 st037298 9.481 µM 0.736353845092013 0.204825879399059 no 699 0.230757692733037 1106 597396 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.735714885965686 0.205028338252752 no 700 0.230952114266095 1183 5393153 SGTC_206 4546-0025 72.014 µM 0.735483835068134 0.20510157768677 no 701 0.231022440596923 1158 6620745 YIL048W NEO1 SGTC_767 0929-0023 86 µM 0.73517298407623 0.205200136999888 no 702 0.231117075011621 1226 1204563 SGTC_989 1501-0895 10.3 µM 0.734947843431063 0.205271538311672 no 703 0.231185629566949 1144 2830112 SGTC_79 0052-0007 94.094 µM 0.734288158588082 0.205480836337192 no 704 0.231386566655159 1142 2801472 SGTC_2371 9071574 200 µM 0.733560801761981 0.205711751454346 no 705 0.231608229179004 1120 45596039 SGTC_750 4073-0104 132 µM 0.733495674631612 0.205732434976472 no 706 0.231628082490915 980 22330957 SGTC_800 3448-7362 155 µM 0.731921909431068 0.206232617298248 no 707 0.23210811631879 1244 15991913 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.731778518510074 0.206278226357112 no 708 0.232151881288201 1134 6708739 YPR165W RHO1 SGTC_117 lucigenin 22.078 µM 0.731134505358813 0.206483144513499 no 709 0.232348499982551 1157 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3338 9144300 39.5675 µM 0.730548087785125 0.206669841228581 no 710 0.232527615165423 1124 4901274 SGTC_2459 5811157 9.22 µM 0.728613978983207 0.207286308124289 no 711 0.233118912552366 1125 2870684 YBR192W RIM2 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.728279211373748 0.207393120341012 no 712 0.233221342674579 1101 15053 SGTC_1159 4092-0538 61.2 µM 0.727479995561256 0.207648252683327 no 713 0.233465982764134 1195 717301 SGTC_372 0155-0182 15.9 µM 0.726497122487367 0.207962267748855 no 714 0.233767035441104 1156 771486 SGTC_1924 st058459 75.1 µM 0.725879883780966 0.208159610662559 no 715 0.233956204748363 1140 688683 SGTC_3343 9148379 18.9835 µM 0.725822302563313 0.208178026103132 no 716 0.233973856375958 1179 1955036 SGTC_1634 st006576 41 µM 0.725444689737363 0.20829881685055 no 717 0.234089632559992 1135 3915356 SGTC_3306 9127676 59.7925 µM 0.725384552523291 0.208318057351647 no 718 0.234108073572647 1144 41905287 SGTC_2910 7948405 25.97 µM 0.723663367723145 0.208869183246088 no 719 0.23463621393899 1117 2971328 SGTC_2058 5236698 133 µM 0.721403855938214 0.209593984755168 no 720 0.23533053744548 1135 766665 SGTC_130 0136-0219 337.655 µM 0.720207623334687 0.209978307925691 no 721 0.235698585451632 1116 234244 SGTC_828 2074-0507 139 µM 0.720146118073247 0.209998079397626 no 722 0.235717517512501 1183 X828 SGTC_1468 k284-1086 134 µM 0.71949417267723 0.210207720908862 no 723 0.235918245711145 1173 15996457 SGTC_1160 4092-0570 10.5 µM 0.718317342697273 0.210586456918816 no 724 0.236280819619811 1165 4994975 SGTC_2476 5806916 10.51 µM 0.716650342096593 0.211123627972762 no 725 0.236794936751239 1090 2870194 SGTC_412 gemfibrozil 100 µM 0.71528026052014 0.211565721035158 no 726 0.237217941681415 1158 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_679 0422-0091 41.4 µM 0.714203137353959 0.211913663539546 no 727 0.237550788581947 1210 627384 YHR062C RPP1 SGTC_1320 1313-0481 95.3 µM 0.714043932929582 0.211965119636588 no 728 0.237600006823541 1193 6813365 YLR208W SEC13 SGTC_2253 7938677 135.83 µM 0.713629333576927 0.212099155634353 no 729 0.237728206975835 1176 2301972 SGTC_1310 1188-0297 994 nM 0.710543762577123 0.213098246957806 no 730 0.238683501460224 1140 1588352 SGTC_1915 st067105 30.6 µM 0.709392764249321 0.213471635930067 no 731 0.239040388361269 1188 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2416 tofa 880 nM 0.708650617617143 0.213712593657645 no 732 0.239270658334543 1114 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2211 7117706 200 µM 0.707942366915927 0.213942693835115 no 733 0.239490524192688 1130 822771 SGTC_300 r073-0011 5.04 µM 0.707461869552224 0.214098882404433 no 734 0.239639750211254 1214 2735780 SGTC_3301 9125354 19.7965 µM 0.707244738246159 0.214169484009108 no 735 0.239707200400284 1150 41905162 SGTC_1790 st045711 43.5 µM 0.707214973186494 0.214179163360436 no 736 0.239716447497091 1188 585119 SGTC_3280 9140961 49.47 µM 0.706672542858959 0.21435560179824 no 737 0.239884998159348 1157 4901226 SGTC_1573 oleylamine 1.06 µM 0.705488039821914 0.214741183457133 no 738 0.240253286194472 1192 5356789 An amine of the fatty acid oleic acid. SGTC_2443 5493264 126.67 µM 0.70364986789246 0.21534034593972 no 739 0.240825423799492 1172 5340055 SGTC_1545 lovastatin 49.4 µM 0.702294085622496 0.215782891699025 no 740 0.241247890452434 1241 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2905 7799065 20.05 µM 0.701747124742259 0.215961576288389 no 741 0.241418439389824 1129 1296806 SGTC_2925 9010536 32.5 µM 0.701026355994793 0.216197172381781 no 742 0.241643283680962 1178 2994177 SGTC_210 3551-0445 56.827 µM 0.70061392292538 0.216332050387798 no 743 0.241771993572103 1209 2865180 YOR207C RET1 SGTC_3203 9113543 49.47 µM 0.699525550993103 0.216688214487987 no 744 0.242111825389952 1197 17018012 SGTC_1187 1391-0724 117 µM 0.699306142041619 0.216760055989108 no 745 0.242180364706816 1223 6997986 SGTC_2368 9071271 200 µM 0.699017793353619 0.216854491504267 no 746 0.24227045552086 1179 27209959 SGTC_856 0433-0016 11.3 µM 0.698705502520929 0.216956795006596 no 747 0.242368047232971 1199 3911780 SGTC_1332 1480-0653 17.5 µM 0.698287800606689 0.217093673773918 no 748 0.242498613479116 1181 5749438 SGTC_2152 5568786 200 µM 0.696316686627089 0.21774027060321 no 749 0.243115262681125 1180 5399883 SGTC_921 1561-0023 372 µM 0.695918805245071 0.217870924754943 no 750 0.243239839859569 1212 24050882 SGTC_1370 2001-0092 44.6 µM 0.695818252453541 0.217903950896331 no 751 0.243271328530882 1269 790957 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.692975608570887 0.218838799077752 no 752 0.244162429361363 1196 5377381 SGTC_611 3453-1652 23.7 µM 0.690516230562021 0.219649462887112 no 753 0.244934803356041 1211 1560575 SGTC_1355 1499-0035 1.68 µM 0.689910167848371 0.219849498687478 no 754 0.245125340621986 1214 1548538 SGTC_991 3996-0057 64.7 µM 0.689551517809697 0.219967923203183 no 755 0.245238132489123 1181 715343 SGTC_1574 spiramycin 23.7 µM 0.689376255520356 0.220025807278251 no 756 0.245293260882443 1229 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3255 9139072 49.47 µM 0.686430955326473 0.220999861454679 no 757 0.246220694866294 1224 17646060 SGTC_919 tnp00227 403.569 nM 0.686408455688314 0.221007311903013 no 758 0.246227786918064 1213 1269246 A methoxyflavone. YNL221C POP1 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.686076150955147 0.221117366822787 no 759 0.246332544572954 1227 551469 SGTC_1643 st009866 20.2 µM 0.684365560172215 0.221684387735089 no 760 0.246872178862527 1216 3156273 YOR207C RET1 SGTC_2958 9077254 16.72 µM 0.682948166710662 0.222154849344099 no 761 0.247319798094382 1235 16457351 SGTC_3114 9122766 49.47 µM 0.681944105347718 0.222488462170694 no 762 0.247637147533042 1164 17176985 SGTC_1923 st058458 19.1 µM 0.679187236701493 0.223405936347783 no 763 0.248509616640616 1272 3534982 SGTC_1026 k007-1105 30.6 µM 0.679013572650333 0.223463802988626 no 764 0.248564631068653 1225 7066794 SGTC_2954 9074818 52.69 µM 0.678345188188731 0.22368659508271 no 765 0.248776426773854 1209 16648742 SGTC_1022 4477-0945 21.3 µM 0.677700385668153 0.223901646263449 no 766 0.248980840928959 1208 4648966 SGTC_1527 coumarin 137 µM 0.6756122099231 0.224598889538718 no 767 0.249643443659078 1256 323 A hepatotoxic, DNA x-linker. SGTC_3263 9137018 49.47 µM 0.674541609225722 0.224956840925385 no 768 0.249983520703517 1186 43844957 SGTC_1803 st050068 52.4 µM 0.673437066329099 0.225326479404902 no 769 0.250334636995747 1318 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2154 5570129 200 µM 0.672700415197945 0.225573192898121 no 770 0.250568951701042 1248 673366 SGTC_2531 methyl deoxycholate 70.07 µM 0.67233768391056 0.225694732200531 no 771 0.250684372299324 1209 16667744 Haematoxylin. SGTC_869 0564-0080 44.1 µM 0.672274156200939 0.225716022054592 no 772 0.250704589626634 1220 6843321 SGTC_568 1193-0097 7.48 µM 0.671553704033935 0.225957544552836 no 773 0.250933929786301 1152 3646150 SGTC_1800 st050079 29.0735 µM 0.670365673337186 0.226356135800983 no 774 0.251312355701521 1207 3645560 SGTC_1943 st076331 65.2 µM 0.670156052387465 0.226426506050305 no 775 0.251379158004258 1288 24208415 SGTC_1464 k208-0027 110 µM 0.669392031850087 0.226683094100253 no 776 0.251622716584572 1262 X1464 SGTC_1175 0741-0056 27.6 µM 0.669194112433209 0.226749589950218 no 777 0.251685830723744 1287 765927 SGTC_80 0159-0065 512.242 µM 0.669169232344579 0.226757949800834 no 778 0.251693765278504 1180 1548079 SGTC_1686 st019653 115.5 µM 0.665589435089188 0.227962593132961 no 779 0.252836780554286 1259 97252 SGTC_3123 9126162 49.47 µM 0.665084162512399 0.228132912669864 no 780 0.252998331891982 1298 25239884 SGTC_374 0880-0231 82.3 µM 0.663309447549166 0.228731708206002 no 781 0.253566193533669 1220 6833587 SGTC_740 k014-0057 261 µM 0.661236923143471 0.229432101379155 no 782 0.254230192865512 1265 4012779 SGTC_1694 st024011 44.9 µM 0.661201228049829 0.229444174772525 no 783 0.254241636909056 1299 2787533 SGTC_307 1501-1223 22.3 µM 0.661154157838138 0.229460096193477 no 784 0.254256728291 1238 2830329 SGTC_2694 st077685 81.9 µM 0.660757681416564 0.229594228253399 no 785 0.254383862929704 1221 2838096 SGTC_1603 st002045 67.8 µM 0.660605875757394 0.229645597299286 no 786 0.254432549946777 1243 5887985 SGTC_336 4111-0029 111 µM 0.659620140874028 0.229979313648905 no 787 0.254748812992206 1201 3131175 SGTC_2384 9036245 200 µM 0.659219576868354 0.230115000404091 no 788 0.254877388681932 1253 6462766 SGTC_135 0933-0004 26.348 µM 0.658906967807588 0.230220924475493 no 789 0.254977755601718 1225 21230617 YGL099W LSG1 SGTC_1183 1254-0324 198 µM 0.658716098465797 0.230285611816213 no 790 0.255039046678587 1270 5799357 SGTC_982 1491-0518 27.5 µM 0.657297591758715 0.230766674874368 no 791 0.255494792341745 1231 3091256 SGTC_1673 st016611 27.3 µM 0.656262704625813 0.231117993546767 no 792 0.255827554837418 1295 5226799 SGTC_1158 4092-0494 91.8 µM 0.656143593297494 0.231158448051317 no 793 0.255865868967814 1337 1148199 SGTC_2713 st079149 53.4 µM 0.655378353488022 0.231418445314143 no 794 0.256112092425184 1274 3103253 SGTC_1316 1272-0050 65.9 µM 0.654462946026097 0.231729677511117 no 795 0.256406796052405 1263 7340392 SGTC_1696 st025591 34.7925 µM 0.654034270895297 0.231875504227062 no 796 0.25654486320817 1273 2787147 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.649851057204507 0.233301229870139 no 797 0.257894217540439 1288 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1828 st055811 49 µM 0.649612869088144 0.233382555421367 no 798 0.257971159119456 1234 5877589 SGTC_1213 1315-0166 115 µM 0.648615872370075 0.233723134769224 no 799 0.25829334678494 1227 768401 SGTC_2536 dehydroabietamide 32.04 µM 0.644588870311341 0.235101579882339 no 800 0.259596824624327 1323 3983547 SGTC_1873 rapamycin 2 nM 0.644199531197295 0.235235088531639 no 801 0.259723027437652 1272 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2260 7964312 200 µM 0.644018636515901 0.235297133541154 no 802 0.259781674541945 1311 231951 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.643893588938077 0.235340028851003 no 803 0.259822219685796 1286 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1774 st048371 48.465 µM 0.642548467644925 0.235801721234655 no 804 0.260258565135615 1244 4242727 SGTC_1499 4480-0877 67.3 µM 0.642462704195516 0.235831175157017 no 805 0.260286398839903 1218 2861909 SGTC_1203 3992-3522 103 µM 0.641260496913509 0.236244265159285 no 806 0.260676725048603 1481 5322312 SGTC_2040 5100729 123 µM 0.640823500485985 0.236394520030805 no 807 0.260818681319695 1298 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2270 7924575 90.91 µM 0.640741238232877 0.236422810593616 no 808 0.260845408279772 1281 1262135 SGTC_2953 9074162 66.49 µM 0.640658776232307 0.236451171721308 no 809 0.260872201551608 1261 16451992 SGTC_2338 7999974 200 µM 0.639259356609559 0.236932759063725 no 810 0.261327111957638 1336 315925 SGTC_1448 4255-0083 152 µM 0.633656328247273 0.238866340013563 no 811 0.263152565781169 1363 5399660 SGTC_1267 0828-0272 9.49 µM 0.633388306538188 0.238959048942391 no 812 0.26324004962925 1350 745334 SGTC_1311 1190-0148 100 µM 0.63196196231136 0.239452753375696 no 813 0.263705866449954 1342 1961333 SGTC_528 3492-0019 172 µM 0.631126776261609 0.2397420969718 no 814 0.263978817320669 1346 2869262 SGTC_3251 9135047 49.47 µM 0.6289965728358 0.240480952153687 no 815 0.264675649952293 1333 17682963 SGTC_1103 duloxetine 36.1 µM 0.628610079259478 0.240615139163704 no 816 0.264802180011151 1381 60835 A selective serotonin reuptake inhibitor. SGTC_1972 st070201 17.4 µM 0.628599961169669 0.240618652618728 no 817 0.264805492878964 1301 2829099 SGTC_1119 parthenolide 318.541 nM 0.626828876837719 0.241234082708233 no 818 0.265385706267182 1404 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3079 9117512 49.47 µM 0.625747145029812 0.241610391660895 no 819 0.265740402472178 1338 7185044 SGTC_1732 st034308 51.822 µM 0.623777283164308 0.242296477954046 no 820 0.26638693024523 1287 830119 SGTC_321 4534-3890 65.3 µM 0.623736073431206 0.242310842223273 no 821 0.266400464173512 1330 699746 SGTC_2730 imipramine 71.33 µM 0.622834484859408 0.242625219875388 no 822 0.266696647160814 1315 3696 A tricyclic antidepressant. SGTC_2928 9011484 9.79 µM 0.622738297983639 0.24265877260147 no 823 0.266728255561942 1297 2994751 SGTC_2136 5328288 199.296 µM 0.622116445019367 0.242875753262726 no 824 0.266932651137782 1283 262395 SGTC_530 4358-1714 28 µM 0.621911001340548 0.242947460966104 no 825 0.267000195382278 1342 1564641 SGTC_2359 9039622 200 µM 0.621287520402425 0.243165149770978 no 826 0.267205231639619 1275 6463596 SGTC_406 estrone 100 µM 0.620843814630752 0.243320134160214 no 827 0.267351195906801 1382 5870 A steroid. SGTC_3340 9146634 11.102 µM 0.620284565900829 0.243515553198902 no 828 0.267535227202965 1312 4907387 SGTC_1719 st032227 49.2 µM 0.61969762681352 0.243720739260033 no 829 0.267728439201319 1314 3125804 SGTC_1319 1306-0155 43.7 µM 0.618203887443402 0.244243351345861 no 830 0.268220473924209 1340 3122360 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.615142940318837 0.245316164513141 no 831 0.269230163124564 1311 521171 SGTC_1179 1021-1431 9.29 µM 0.613803441024451 0.245786433188997 no 832 0.269672611561715 1331 2840958 SGTC_881 0833-0569 170 µM 0.612896667534785 0.246105055862224 no 833 0.269972333443528 1289 5418700 SGTC_205 1486-1330 71.903 µM 0.612334632134939 0.246302655394651 no 834 0.270158190400318 1328 4118834 SGTC_606 k015-0008 38.6 µM 0.612266495650251 0.24632661649319 no 835 0.270180726496483 1399 1970475 SGTC_1181 1222-0449 220 µM 0.610009535546895 0.247121012162666 no 836 0.270927745479076 1383 658318 SGTC_1718 roemerine 11.9335 µM 0.609207836082737 0.247403520560302 no 837 0.271193343477023 1267 235224 An aporphine alkaloid with mutagenic activity. SGTC_2943 9068529 45.32 µM 0.607988373121804 0.247833574098992 no 838 0.271597592647389 1328 3270634 SGTC_1117 retinoic acid 1.10837 µM 0.607513819782125 0.248001036997186 no 839 0.271754987052139 1368 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2227 7312221 64.1025 µM 0.607206645243304 0.248109466558205 no 840 0.271856891374264 1334 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1826 st055655 41.6 µM 0.606827321171617 0.248243399074852 no 841 0.271982757338419 1373 676168 SGTC_1431 4049-0260 9.09 µM 0.606675742591087 0.24829692952771 no 842 0.272033061707275 1335 3854841 SGTC_1808 st050063 61.5 µM 0.605363269632383 0.248760690713683 no 843 0.272468825349709 1358 4011993 SGTC_3003 9075612 71.4286 µM 0.605133785669592 0.248841826019418 no 844 0.272545053568802 1338 6501993 SGTC_940 3232-1287 54.8 µM 0.604921632806801 0.248916846350131 no 845 0.27261553429371 1314 1585493 YIL048W NEO1 SGTC_2033 5192550 145 µM 0.603889071127578 0.249282146944416 no 846 0.272958697647755 1309 182073 SGTC_2524 avocatin b 10.57 µM 0.602600569150499 0.249738393798153 no 847 0.273387220827119 1288 6710748 SGTC_3227 9130768 49.47 µM 0.60208482812565 0.249921137199579 no 848 0.273558836556532 1366 17720899 SGTC_2181 6316240 54.2555 µM 0.601560778829896 0.250106897155927 no 849 0.273733271502885 1315 12779990 SGTC_1446 4239-0190 62 µM 0.600951607375378 0.25032292241681 no 850 0.273936109317037 1326 1340085 SGTC_2528 xanthyletin 44.79 µM 0.600080870526598 0.250631876042887 no 851 0.274226170354772 1374 65188 An natural product with antifungal activity of unknown mechanism. SGTC_151 3013-0144 2.285 µM 0.599801866763481 0.250730914477895 no 852 0.274319144543253 1391 906558 YHR107C CDC12 SGTC_1925 st057770 10.1 µM 0.597417021866393 0.251578311847292 no 853 0.27511449595939 1261 5989122 SGTC_1274 0865-0114 173 µM 0.596017916714044 0.252076153545297 no 854 0.275581628803297 1352 870624 SGTC_2355 9061122 103.12 µM 0.595986893519084 0.252087198373758 no 855 0.275591991237621 1341 5302957 SGTC_2337 9009472 200 µM 0.591330587980093 0.253747819350785 no 856 0.277149469262682 1433 5742383 SGTC_1787 fluconazole 80 µM 0.591135400971179 0.253817555904319 no 857 0.277214850894369 1259 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3164 9100705 49.47 µM 0.589551497186951 0.254383826049306 no 858 0.277745688704891 1395 17174235 SGTC_3207 9114163 49.47 µM 0.588892416904618 0.254619652401006 no 859 0.277966722486813 1493 849233 SGTC_2630 antimycin a 100 µM 0.588545380163225 0.254743872062084 no 860 0.278083141649552 1321 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_952 1185-0122 232 µM 0.586887312864871 0.25533780469492 no 861 0.278639695573714 1292 678600 SGTC_236 1509-0011 5.31 µM 0.586812029433664 0.255364788974327 no 862 0.278664978397713 1387 3107280 SGTC_1402 3909-7673 35.9 µM 0.58665836406889 0.25541987277305 no 863 0.278716588098404 1340 5328014 SGTC_1760 st045453 10.4495 µM 0.585362634018387 0.255884594657875 no 864 0.279151953999394 1380 3323419 YIL048W NEO1 SGTC_3205 9113483 49.47 µM 0.58517970190117 0.255950239962165 no 865 0.279213445897973 1407 17018033 SGTC_111 0083-0039 52.457 µM 0.584842620237718 0.25607122493694 no 866 0.27932677178909 1281 759313 SGTC_2750 bromebric acid 70.15 µM 0.584516591427576 0.256188271205583 no 867 0.279436402998928 1415 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1322 1348-1070 12 µM 0.583348058828446 0.256608010365957 no 868 0.279829508096906 1344 6758089 SGTC_847 0342-0274 5.54 µM 0.582586617646276 0.256881714104463 no 869 0.280085808170892 1391 18097 SGTC_1663 st014140 55.4 µM 0.582018889819408 0.257085885452144 no 870 0.280276978601159 1436 4207120 SGTC_798 1287-0182 476 µM 0.580618827591405 0.257589748780557 no 871 0.280748690100344 1410 1649755 SGTC_1878 temozolomide 1 mM 0.580482862842629 0.257638707947472 no 872 0.280794520035164 1387 5394 DNA alkylating agent. SGTC_1796 st049173 110.4 µM 0.580317538723513 0.257698245556925 no 873 0.280850251070263 1326 94134 SGTC_140 0062-0056 502.533 µM 0.579570725568955 0.257967281805929 no 874 0.28110206964312 1310 3758964 SGTC_1027 k015-0025 8.67 µM 0.579541731421594 0.25797772976106 no 875 0.281111848403742 1342 3598955 SGTC_903 1134-0042 114 µM 0.579099234717577 0.258137209371461 no 876 0.281261108196941 1351 701009 SGTC_2427 5545055 42.75 µM 0.578492451335619 0.25835598238997 no 877 0.281465846174507 1424 5372858 SGTC_796 1234-0020 70.7 µM 0.577621330303758 0.258670229045137 no 878 0.281759901368912 1326 46495034 SGTC_23 0213-0011 39.996 µM 0.57743110909585 0.258738875418699 no 879 0.281824132040401 1418 627608 SGTC_1791 st048313 56.1 µM 0.5757782825581 0.259335738420986 no 880 0.282382527297491 1354 1204976 SGTC_162 k030-0015 37.8 µM 0.575070288082733 0.25959162439588 no 881 0.282621880713861 1440 1809920 YMR134W ERG29 SGTC_1782 st039423 80.636 µM 0.575069797532241 0.259591801737629 no 882 0.28262204658926 1339 2068169 SGTC_891 0929-0073 133 µM 0.573669804395874 0.26009817606697 no 883 0.283095632669114 1432 5603632 SGTC_1003 4049-0218 100 µM 0.573573451969861 0.260133045240021 no 884 0.283128240522283 1428 295161 SGTC_604 1000-0114 314 µM 0.572933748552312 0.260364609887357 no 885 0.283344776403996 1449 1572745 SGTC_1903 st060211 78.3 µM 0.572620525685358 0.26047803136585 no 886 0.283450829472151 1407 688960 SGTC_417 st075190 100 µM 0.572255305991714 0.260610313595561 no 887 0.283574511991215 1459 222757 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.570661077211167 0.261188146424992 no 888 0.2841147039406 1272 6708630 An antioxidant. SGTC_575 k072-0246 11.9 µM 0.57026214198393 0.261332844572345 no 889 0.284249956968414 1393 6796779 SGTC_3336 9143619 71.43 µM 0.570043845564901 0.261412040485673 no 890 0.284323980135047 1407 45595730 SGTC_3200 9114385 49.47 µM 0.569369741920901 0.261656676798698 no 891 0.284552623266974 1341 17018030 YLR208W SEC13 SGTC_1104 tacrolimus 29.8 µM 0.564692924703366 0.263357151291078 no 892 0.286141323754838 1417 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3237 9133362 49.47 µM 0.564577933065274 0.26339903281515 no 893 0.286180439078359 1430 43845137 SGTC_2771 fluoxetine 41.05 µM 0.564402550606626 0.263462916047583 no 894 0.28624010171166 1430 3386 A selective serotonin reuptake inhibitor. SGTC_182 3448-4371 550.524 µM 0.564239801072241 0.263522204798769 no 895 0.286295472085997 1448 3491403 SGTC_2521 angolensin 13.4 µM 0.564104376037424 0.263571544576285 no 896 0.286341550040817 1431 821428 A flavenoid. SGTC_1515 3460-0031 42.1 µM 0.563441364051929 0.263813169579324 no 897 0.286567188639287 1354 2876596 SGTC_1379 2144-0755 36.5 µM 0.5617644398471 0.264424803724368 no 898 0.287138261576824 1419 5392327 SGTC_1642 st009582 77.7 µM 0.561637296645901 0.264471206808397 no 899 0.28718158188575 1448 6739311 SGTC_2777 climbazole 1.536 µM 0.561468555261688 0.264532798259088 no 900 0.287239080330154 1405 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1388 3346-4487 254 µM 0.56094694364918 0.2647232352485 no 901 0.287416853367146 1444 3345614 SGTC_1500 4488-1866 171 µM 0.560886945121095 0.264745144788659 no 902 0.287437305099435 1486 2900003 SGTC_1193 1488-0126 41.5 µM 0.560101280103401 0.265032129544185 no 903 0.287705178675863 1396 1384710 SGTC_2720 fluspirilene 36.88 µM 0.559314417216469 0.265319710177783 no 904 0.287973578841425 1403 3396 An atypical antipsychotic. SGTC_3331 9141060 1.957 µM 0.557546238511089 0.26596651697466 no 905 0.288577138250998 1350 4906567 YPR165W RHO1 SGTC_3026 9090633 49.47 µM 0.555962390750229 0.266546572267173 no 906 0.289118282657531 1366 25236842 SGTC_2824 7998404 51.95 µM 0.554962204992413 0.266913201304805 no 907 0.289460256166649 1418 837851 SGTC_2061 5245884 80.95 µM 0.552321525846632 0.267882393748821 no 908 0.290364042542872 1389 573863 SGTC_1717 st033143 58.0435 µM 0.551534867097004 0.268171458630168 no 909 0.29063353586926 1496 674616 SGTC_2814 7977482 42.97 µM 0.549833051907112 0.26879734266401 no 910 0.291216943239289 1507 6456762 SGTC_1635 st007035 42.4 µM 0.547346604976831 0.26971311130838 no 911 0.292070315547605 1444 3716403 SGTC_1450 4112-4260 37.6 µM 0.546987186647282 0.269845615710153 no 912 0.292193767574024 1424 1633175 SGTC_2778 tioconazole 65.09 nM 0.54634226815202 0.270083455264368 no 913 0.292415343261972 1367 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2805 7950783 58.44 µM 0.546187543678301 0.270140531712618 no 914 0.292468513815533 1459 1178958 YDL195W SEC31 SGTC_1141 3253-0389 52.6 µM 0.544658475768064 0.270704915157862 no 915 0.292994214436128 1401 5402031 SGTC_2825 7998094 58.44 µM 0.544459535656261 0.270778387796575 no 916 0.293062643185173 1430 2987815 SGTC_1674 st016616 23.6 µM 0.54295307735857 0.271335076457618 no 917 0.293581054931154 1359 625830 SGTC_3085 9117376 49.47 µM 0.542472970209948 0.271512612498182 no 918 0.293746361551119 1483 16480349 SGTC_320 4092-0846 5.34 µM 0.542433355369939 0.271527264023866 no 919 0.29376000333662 1459 1359356 SGTC_2207 7258803 200 µM 0.542000037520982 0.271687552085779 no 920 0.293909240017698 1430 3666799 SGTC_3036 9090181 49.47 µM 0.540391671179682 0.272282912438682 no 921 0.294463475227004 1448 25236586 SGTC_1579 chlormadinone acetate 49.4 µM 0.540225618030611 0.27234441634199 no 922 0.294520723796921 1506 45114258 A steroidal progestin. SGTC_724 3910-0327 137 µM 0.538860730309664 0.272850214165675 no 923 0.29499147769209 1398 2885483 SGTC_1742 st038235 28.8875 µM 0.537750771987399 0.273261883906083 no 924 0.295374561059729 1444 564103 YBR002C RER2 SGTC_1861 st057647 17.4 µM 0.536968074554473 0.273552361511355 no 925 0.295644833388238 1530 688668 SGTC_3199 9111318 49.47 µM 0.535742255902559 0.274007598788144 no 926 0.29606834764498 1468 8548020 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.534136250403269 0.274604593633702 no 927 0.29662363553861 1457 5379071 SGTC_132 0417-1715 25.805 µM 0.531138893015554 0.275720504176556 no 928 0.297661267168201 1532 6769098 SGTC_234 nsc-17383 10.7 µM 0.527088609985525 0.277231949111361 no 929 0.299066027992173 1495 408974 SGTC_1893 st059353 36.1 µM 0.525660517425449 0.277765835473232 no 930 0.299562050484675 1400 3112488 SGTC_1173 0443-0020 122 µM 0.523988906540035 0.278391397220702 no 931 0.300143127866801 1445 5331295 SGTC_260 nsc-65238 3.989 µM 0.522763314824421 0.278850482407561 no 932 0.300569485788057 1483 3246252 SGTC_361 000s-0510 1.45 µM 0.521884287632434 0.27917997730208 no 933 0.300875449405936 1446 660 SGTC_2932 9016711 44.54 µM 0.521349835135568 0.279380404155916 no 934 0.301061545305765 1541 7117328 SGTC_3267 9137951 49.47 µM 0.520515779531646 0.279693325780218 no 935 0.301352066352093 1485 16643986 SGTC_2279 7948423 32.93 µM 0.520315787067156 0.279768384381102 no 936 0.301421747155339 1593 1247112 SGTC_2934 9036370 36.88 µM 0.520267938260262 0.279786343828871 no 937 0.301438419575033 1555 6462800 SGTC_2480 5767542 37.17 µM 0.52013746489238 0.279835318207962 no 938 0.301483883773498 1512 2867358 SGTC_906 1165-0455 526 µM 0.51728526123671 0.280906956821909 no 939 0.302478520594941 1416 3252859 SGTC_848 0368-0089 85.6 µM 0.51702685666587 0.281004143286149 no 940 0.302568705560196 1432 762535 SGTC_2420 aureobasidin a 50 nM 0.516779032036002 0.281097365874615 no 941 0.302655209373411 1602 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_912 3474-0017 2.18 µM 0.51677124362954 0.281100295831224 no 942 0.302657928115952 1552 3360550 SGTC_2292 7671323 168.05 µM 0.516079057611037 0.2813607513877 no 943 0.302899597042269 1443 937504 SGTC_1374 2889-5571 141 µM 0.515530517556795 0.281567238574307 no 944 0.303091174933807 1451 2853281 SGTC_1403 3909-7815 62.9 µM 0.513393659242632 0.282372313344512 no 945 0.303837990054321 1494 6615483 SGTC_2331 7980721 200 µM 0.512422090628277 0.282738723746882 no 946 0.304177816858136 1530 2981221 SGTC_816 0325-0417 81.3 µM 0.510803093960121 0.283349807528693 no 947 0.304744471238586 1447 68101 SGTC_2097 5376186 200 µM 0.510112396985232 0.283610700901763 no 948 0.304986360274919 1518 742755 SGTC_2823 7987624 58.44 µM 0.509210450767464 0.283951561514343 no 949 0.305302359243931 1481 2239440 SGTC_441 propafenone 146 µM 0.507750011383264 0.284503901411772 no 950 0.305814335344674 1429 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2187 6125751 200 µM 0.506878713623841 0.284833671483861 no 951 0.306119961087214 1478 874498 SGTC_1880 MG-132 525 µM 0.506506816977597 0.28497448299333 no 952 0.306250452662345 1523 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_907 3448-6986 75.5 µM 0.506431849292976 0.285002872084741 no 953 0.306276760397884 1576 590582 SGTC_1606 st000094 49.2 µM 0.506357561013206 0.285031005226405 no 954 0.306302830701269 1516 1242210 SGTC_399 oxolinic acid 75 µM 0.505419692828285 0.285386291887649 no 955 0.306632045097706 1437 4628 A DNA gyrase inhibitor. SGTC_559 1550-0661 158 µM 0.504497181149812 0.2857359667653 no 956 0.306956021267886 1538 5830875 SGTC_854 0422-0053 192 µM 0.503783785263604 0.286006516687911 no 957 0.30720666164319 1457 3596728 SGTC_1778 st046819 58.9 µM 0.502806099564799 0.286377494129342 no 958 0.307550302394654 1490 671715 SGTC_590 k048-0076 22.4 µM 0.502185245451809 0.286613192306062 no 959 0.307768610334894 1543 6832814 SGTC_3187 9109394 49.47 µM 0.501986686716923 0.286688591636191 no 960 0.307838442956364 1388 17098090 SGTC_12 0849-0099 9.267 µM 0.500800688719856 0.287139150116467 no 961 0.30825570044026 1514 6071388 SGTC_1225 1216-0074 20.6 µM 0.499730510321946 0.287545996448545 no 962 0.308632423088848 1446 4241466 SGTC_1430 4049-0248 69.1 µM 0.494547042500598 0.289520425804558 no 963 0.310459945979671 1583 22774488 SGTC_2716 st080858 38.6235 µM 0.494103114741436 0.289689817417576 no 964 0.310616679127444 1492 5296050 SGTC_544 k015-0020 52.4 µM 0.493497788185473 0.289920869657837 no 965 0.310830451140304 1499 3008304 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.493328448089617 0.289985521985293 no 966 0.310890265293447 1443 6708514 SGTC_2641 levomentholum 100 µM 0.492567301252079 0.290276203553083 no 967 0.311159178570531 1469 16666 SGTC_2198 6589944 200 µM 0.492532568342105 0.290289471288053 no 968 0.311171452118799 1503 5290268 SGTC_1149 3909-7961 23.3 µM 0.492082120771519 0.290461564912872 no 969 0.311330645530604 1441 735261 SGTC_2857 9024691 58.44 µM 0.492081199010989 0.290461917120705 no 970 0.311330971327688 1504 16478292 SGTC_1044 1222-0021 1.78 µM 0.492029037677625 0.290481848469315 no 971 0.311349408038453 1520 4306703 SGTC_2346 9031566 143.75 µM 0.491711533247231 0.290603183779724 no 972 0.311461641934019 1563 4771086 SGTC_2015 5119600 184 µM 0.490488802470483 0.291070675513306 no 973 0.311894025773066 1602 2828786 SGTC_3157 9099274 49.47 µM 0.489935884884833 0.291282190066203 no 974 0.312089634494597 1498 17217662 SGTC_1443 4112-3303 14 µM 0.489420232189706 0.291479513836981 no 975 0.312272107569119 1496 704433 SGTC_1101 ebselen 5.29 µM 0.488699226782089 0.291755524004374 no 976 0.312527325644749 1602 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1375 2910-0797 186 µM 0.488149279644555 0.291966132701433 no 977 0.312722053796372 1525 742508 SGTC_2999 9069765 71.4286 µM 0.487805379312941 0.292097869326452 no 978 0.312843850392406 1562 2097066 SGTC_667 1498-1044 59 µM 0.485201539028224 0.293096209309183 no 979 0.313766695226645 1543 6739982 SGTC_993 3909-8757 62.7 µM 0.483367351007419 0.293800405098081 no 980 0.3144174629734 1516 4288324 YLR208W SEC13 SGTC_2965 9082772 38.63 µM 0.482930358729578 0.293968293978397 no 981 0.314572592523793 1608 16459634 SGTC_2 0422-0095 29 µM 0.482469268229724 0.294145489281416 no 982 0.314736312292815 1417 6790840 SGTC_2702 st077768 96.8 µM 0.480006883915488 0.295092608582993 no 983 0.315611249064387 1470 6484119 SGTC_3282 9108498 15.4605 µM 0.479331492100144 0.29535263317982 no 984 0.315851410939793 1484 16459645 SGTC_2601 securinine 100 µM 0.478709216384897 0.295592301448678 no 985 0.316072754147091 1481 442872 A GABA receptor antagonist. SGTC_383 2324-0395 7.37 µM 0.478382104843329 0.295718323658536 no 986 0.316189134031634 1576 3146421 SGTC_191 3914-0123 66.505 µM 0.47749373870626 0.296060697980928 no 987 0.316505289185843 1444 3144412 SGTC_366 0181-0206 4.31 µM 0.476379260758812 0.296490472378323 no 988 0.316902103552128 1676 274874 SGTC_2703 st077852 53.4 µM 0.476325526835543 0.296511200930156 no 989 0.316921241060251 1540 6281836 SGTC_2318 6029776 164 µM 0.475003781554059 0.297021290091214 no 990 0.317392138963247 1595 818325 SGTC_562 3772-2733 112 µM 0.474955819510028 0.297039807191602 no 991 0.317409231954479 1526 2876874 YIL048W NEO1 SGTC_426 0988-0037 14.6 µM 0.473399229625966 0.297641059034838 no 992 0.317964189691813 1532 5383008 SGTC_1222 0366-0074 1.18 µM 0.471223844181207 0.298482257382362 no 993 0.318740446468669 1632 286520 SGTC_3001 9076041 71.4286 µM 0.471060086521225 0.298545624477366 no 994 0.318798913424796 1503 16004211 SGTC_534 k292-0788 63.4 µM 0.469854899848588 0.299012167440102 no 995 0.319229343998637 1610 4146317 SGTC_2733 amorolfine 100 µM 0.46874675026371 0.299441438050621 no 996 0.31962533308742 1588 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_136 0097-0015 404.482 µM 0.467549235297972 0.299905640531248 no 997 0.32005348752898 1542 4861337 SGTC_3024 9090631 49.47 µM 0.46732830627957 0.299991316622842 no 998 0.320132503771212 1556 25236383 SGTC_1987 st072290 61.9 µM 0.466422101266362 0.300342858001306 no 999 0.320456697341458 1550 54697379 SGTC_3156 9099931 49.47 µM 0.465103478071949 0.300854719760355 no 1000 0.320928677693953 1584 18111053 SGTC_815 1582-0027 36.9 µM 0.464142553678823 0.301227978036542 no 1001 0.321272807831912 1583 3128206 SGTC_2254 7938975 95.19 µM 0.463746778453465 0.301381772273544 no 1002 0.321414589109643 1635 2969277 SGTC_1995 st072814 61.1 µM 0.462834571428511 0.301736381222417 no 1003 0.321741474388508 1484 5769371 SGTC_966 1300-0360 30.2 µM 0.462329180100781 0.301932926430305 no 1004 0.321922638533394 1540 70588 SGTC_2199 6590217 200 µM 0.46197960217401 0.302068909904892 no 1005 0.322047974094009 1567 703109 SGTC_416 estradiol valerate 100 µM 0.45940332291829 0.303071912240605 no 1006 0.322972281239716 1540 13791 A steroid. SGTC_1145 3546-0597 10.2 µM 0.458601202626289 0.303384499243517 no 1007 0.323260286427659 1531 875334 SGTC_2127 5253358 187.912 µM 0.45764473145249 0.303757425113638 no 1008 0.323603850547852 1480 20612 SGTC_617 3770-0098 35 µM 0.457364370291804 0.303866776027328 no 1009 0.323704584699909 1553 5962639 SGTC_3322 9139058 2.11 µM 0.456297095870632 0.304283211898498 no 1010 0.32408817600556 1593 4908926 YPR165W RHO1 SGTC_1818 st052136 56.3 µM 0.455464184865475 0.304608378830426 no 1011 0.32438766409981 1489 674169 SGTC_2103 5378138 10 µM 0.45469354484734 0.304909372864106 no 1012 0.32466486275684 1595 244142 SGTC_2248 tofa 1.1 µM 0.453945612464133 0.305201624115851 no 1013 0.324933986392365 1551 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_788 1182-0090 188 µM 0.45386913468294 0.305231514473207 no 1014 0.324961510046118 1699 5715185 SGTC_3017 9080681 49.47 µM 0.453853974813619 0.305237439667459 no 1015 0.324966966057854 1522 16451914 SGTC_3256 9138902 49.47 µM 0.451841489278586 0.306024466860456 no 1016 0.325691589130704 1601 17228773 SGTC_95 0471-0001 561.058 µM 0.451432255869501 0.306184616461482 no 1017 0.325839019973663 1466 4015405 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.451157795249609 0.306292044769571 no 1018 0.325937912696379 1541 6708784 An antioxidant flavonoid SGTC_1353 1498-1206 8.11 µM 0.450456385036316 0.306566663680949 no 1019 0.326190698077586 1536 6756808 SGTC_229 benomyl 22.8748 µM 0.450035436169495 0.306731527431937 no 1020 0.326342444695235 1534 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2324 6149169 200 µM 0.449924334998761 0.306775046499153 no 1021 0.32638250002538 1597 2888231 SGTC_2284 7945075 39.21 µM 0.447963532786041 0.307543553530763 no 1022 0.327089757636496 1696 1245402 SGTC_2788 5282734 71.43 µM 0.447844257290439 0.307590329085377 no 1023 0.327132800154728 1688 743706 SGTC_2098 5376439 882.5 nM 0.446906689788973 0.307958118197425 no 1024 0.327471216790685 1661 2844116 SGTC_2515 chrysin 20.77 µM 0.445840818480899 0.308376472753213 no 1025 0.327856117167008 1639 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1216 1165-0504 9.65 µM 0.445542397566914 0.30849364761561 no 1026 0.327963913744797 1634 6304004 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.445002990055833 0.308705495270488 no 1027 0.328158796652841 1652 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1962 st076595 64.5 µM 0.444802045231156 0.308784430903155 no 1028 0.328231408108921 1560 279619 SGTC_3197 9113331 49.47 µM 0.444471324376768 0.308914364703894 no 1029 0.32835092829183 1665 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3210 9128157 49.47 µM 0.443939091478514 0.309123518883702 no 1030 0.328543310391369 1514 17590849 SGTC_1795 st049545 62.3 µM 0.443792678878649 0.309181066219507 no 1031 0.328596240993751 1654 5291882 SGTC_1737 st035557 69.7 µM 0.443225290788672 0.309404121798571 no 1032 0.328801393754873 1512 5716916 SGTC_3271 9137798 49.47 µM 0.443082235647503 0.309460371728672 no 1033 0.328853126916277 1655 6498326 SGTC_1505 k297-0037 20.6 µM 0.442368553081583 0.309741061622823 no 1034 0.329111265565396 1541 4089396 SGTC_824 1304-0008 100 µM 0.44216542974386 0.30982096991078 no 1035 0.329184750086668 1582 768245 SGTC_3005 9076496 71.4286 µM 0.441685526907038 0.310009798357042 no 1036 0.329358392146844 1599 21368410 SGTC_929 2805-0021 398 µM 0.440256026583269 0.310572563924499 no 1037 0.3298758427271 1616 3098024 SGTC_2153 5569715 200 µM 0.439652957264647 0.310810113332519 no 1038 0.330094239534027 1592 2054701 SGTC_1285 0929-0069 65.5 µM 0.43745762027805 0.311675523661313 no 1039 0.330889752202103 1584 1206237 SGTC_853 0419-0306 21 µM 0.436112627495533 0.312206239710373 no 1040 0.331377507923413 1515 762713 SGTC_924 2046-0044 21.3 µM 0.435989695473014 0.31225476649617 no 1041 0.331422102965938 1518 3623589 SGTC_1534 6-azauridine 81.6 µM 0.435884201157528 0.31229641243337 no 1042 0.331460374180087 1571 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_10 0279-0212 42.575 µM 0.43237347279711 0.313683706053409 no 1043 0.33273499744 1558 39851 YBR002C RER2 SGTC_1491 4138-0063 26.5 µM 0.431804359242209 0.3139088450949 no 1044 0.332941805480741 1625 23883227 SGTC_2981 9013952 38.96 µM 0.430207736125986 0.314540832495542 no 1045 0.333522267516189 1481 2996344 SGTC_129 0088-0017 176.636 µM 0.427732581715431 0.315521641344768 no 1046 0.334422912919436 1674 182446 SGTC_700 3453-2283 142 µM 0.426936596318008 0.315837336677892 no 1047 0.334712754604534 1666 565664 SGTC_1131 3454-3128 32.3 µM 0.426395718390733 0.316051930676727 no 1048 0.33490976038338 1697 710982 SGTC_3165 9101544 49.47 µM 0.425156579160251 0.316543794332862 no 1049 0.335361267438444 1630 5002184 SGTC_190 3970-0790 3.722 µM 0.424224013868781 0.316914180743643 no 1050 0.335701224622301 1646 2832352 SGTC_644 1498-1197 63.3 µM 0.423755943900513 0.317100153030342 no 1051 0.335871905482441 1649 6741615 SGTC_122 0236-0016 402.397 µM 0.421777041039947 0.317886915495176 no 1052 0.33659388259512 1620 6808838 SGTC_470 aa-861 153 µM 0.421303570992997 0.318075277501124 no 1053 0.336766711479283 1557 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1827 berberine 7.24 µM 0.421159134797945 0.318132748356176 no 1054 0.336819441312631 1472 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_221 trifluoperazine 10.304 µM 0.420222419158347 0.318505571756826 no 1055 0.337161489227207 1583 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_271 rotenone 740 µM 0.420178299392754 0.318523136458136 no 1056 0.337177603174318 1641 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1887 st057648 70.8 µM 0.419327735944682 0.31886183745523 no 1057 0.337488314464617 1718 688672 SGTC_737 1950-0117 57.9 µM 0.418982607770739 0.318999313363917 no 1058 0.337614421596706 1676 5393513 SGTC_2486 5283202 22.39 µM 0.417837060687709 0.319455800882229 no 1059 0.338033126184689 1564 1377751 SGTC_3163 9099914 49.47 µM 0.417268649684983 0.319682407880635 no 1060 0.338240958383087 1659 16268368 SGTC_3214 9129694 49.47 µM 0.417038794286713 0.319774062883447 no 1061 0.338325016065547 1713 17158655 SGTC_1953 st076800 12.1 µM 0.416289849581758 0.320072781445561 no 1062 0.338598959604935 1547 297591 SGTC_3022 9087993 49.47 µM 0.415309082405571 0.320464139436719 no 1063 0.338957826636383 1652 17173644 SGTC_2937 9044753 11.33 µM 0.41134888455141 0.322046414883816 no 1064 0.340408364586728 1562 6465530 YGL099W LSG1 SGTC_2766 oltipraz 83.91 µM 0.408980938410317 0.322994060584038 no 1065 0.341276824906527 1684 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2555 cholic acid 100 µM 0.406955156896491 0.323805686210228 no 1066 0.342020462044552 1645 6708657 Influences liver metabolism. SGTC_345 1362-0200 395 µM 0.406093514070267 0.3241511562445 no 1067 0.34233694559071 1565 1419823 SGTC_2851 9015922 71.43 µM 0.403947879151822 0.325012092201781 no 1068 0.343125523501933 1705 2996893 SGTC_696 1560-0013 611 µM 0.40314452644698 0.325334678345434 no 1069 0.343420953089712 1677 1650269 SGTC_2267 7931562 200 µM 0.402597369985172 0.32555446389634 no 1070 0.343622222377897 1520 934880 SGTC_281 1672-3440 14.9 µM 0.402586263778847 0.32555892574173 no 1071 0.343626308210233 1667 6833000 SGTC_732 3970-1727 52.7 µM 0.402214898142358 0.325708133833301 no 1072 0.343762939429828 1748 1275699 SGTC_2870 9038528 12.99 µM 0.402152105800286 0.325733365437578 no 1073 0.343786043731195 1596 6463316 SGTC_583 1488-1091 88.9 µM 0.400071055418496 0.326570036935308 no 1074 0.344552091172625 1719 4303273 SGTC_1690 st023502 41.2 µM 0.399740900550091 0.326702853704345 no 1075 0.34467368192413 1714 24207482 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.399197232764671 0.326921611646331 no 1076 0.344873941030633 1578 2333 A French combination drug. SGTC_2125 5246583 200 µM 0.398600805602979 0.327161667040733 no 1077 0.345093683961083 1788 835267 SGTC_3010 9080089 71.4286 µM 0.398073695518441 0.327373882609162 no 1078 0.345287931746842 1719 17027233 SGTC_2570 licareol 100 µM 0.395796476715897 0.328291335980163 no 1079 0.346127588102213 1596 443158 SGTC_555 4296-0685 37 µM 0.394764009815572 0.328707641504164 no 1080 0.346508529084307 1669 2908540 YHR072W ERG7 SGTC_2041 5107442 45.335 µM 0.394479035563787 0.328822584697804 no 1081 0.346613701096638 1721 793005 SGTC_2790 5423970 71.43 µM 0.392825333356547 0.329489918027815 no 1082 0.347224246196655 1743 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2967 9089538 49.85 µM 0.389757085649078 0.330729513856698 no 1083 0.348358089877922 1823 728216 SGTC_505 gw-5074 63.9 µM 0.388227066014307 0.331348349066229 no 1084 0.348924002571102 1721 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1883 5-benzylidenerhodanine 20 µM 0.386176084681565 0.332178616300361 no 1085 0.349683132118349 1750 1273210 SGTC_2753 fluvastatin 17.09 µM 0.384511983111056 0.332852875053283 no 1086 0.350299508025196 1656 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1437 4092-1038 11.6 µM 0.383199554767118 0.333385024901308 no 1087 0.350785904059669 1633 3977136 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.383127992047073 0.333414051066994 no 1088 0.350812432794972 1692 7104 SGTC_1420 4'-methoxyflavone 42 µM 0.382253390614231 0.333768873942037 no 1089 0.35113671159323 1769 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1867 st057372 64 µM 0.380298224216356 0.334562615815452 no 1090 0.351862026774239 1660 688837 SGTC_639 0833-0042 114 µM 0.380267465696117 0.334575108819961 no 1091 0.351873441690939 1615 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3233 9132340 49.47 µM 0.379719850636996 0.33479756100601 no 1092 0.352076691632161 1596 17682950 SGTC_1442 4112-3290 3 µM 0.37769813626385 0.33561932350443 no 1093 0.352827426236855 1652 704353 SGTC_1309 pyrazolanthrone 13.4 µM 0.376456236711736 0.336124506510162 no 1094 0.353288872308539 1751 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1999 st074831 12.5 µM 0.376427083123668 0.336136369240412 no 1095 0.353299707348251 1649 17112523 SGTC_2988 9073640 71.4286 µM 0.372849655517016 0.337593276608044 no 1096 0.354630171743985 1699 9102229 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.372632585324707 0.337681757095393 no 1097 0.354710958598592 1640 688803 SGTC_1290 0986-0249 10.2 µM 0.372374660080908 0.337786902269893 no 1098 0.354806958943107 1706 53329 SGTC_3042 9091578 49.47 µM 0.370973071724713 0.338358491500212 no 1099 0.355328794272714 1686 25236497 SGTC_2756 carbadox 75.1 µM 0.369607739491213 0.338915653311041 no 1100 0.355837391794339 1662 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_755 1995-0008 37.3 µM 0.369267799680685 0.339054430077396 no 1101 0.355964062126775 1663 689533 SGTC_1059 3448-6867 171 µM 0.367973463010358 0.339583028849895 no 1102 0.356446510752904 1794 3934407 SGTC_2869 9037858 32.47 µM 0.367240552904035 0.339882484693955 no 1103 0.356719796256004 1620 27187042 SGTC_309 k408-0051 1.48 µM 0.366666642831938 0.340117046126769 no 1104 0.356933845627996 1689 3640463 SGTC_2779 methotrexate 400 µM 0.36295136514259 0.341637002256774 no 1105 0.358320607702579 1698 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_720 r052-1644 49.9 µM 0.362487294423214 0.341827039241136 no 1106 0.358493958237162 1671 1422863 YOR257W CDC31 SGTC_2916 7875993 68.79 µM 0.362279291584135 0.34191222942834 no 1107 0.358571665783081 1841 1299250 SGTC_1680 diphenhydramine 100 µM 0.36171656298334 0.3421427423638 no 1108 0.358781924268886 1676 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2662 daunorubicin 22.37 µM 0.361108336292061 0.342391959045731 no 1109 0.359009230838663 1665 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2071 5230951 39.92 µM 0.360680875169245 0.342567149366379 no 1110 0.359169011553897 1718 1799272 SGTC_1078 idebenone 36.1 µM 0.360048559619272 0.342826359161751 no 1111 0.359405409984082 1692 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1762 st045503 25.4615 µM 0.359294141378945 0.343135720235642 no 1112 0.359687528320492 1677 4645554 SGTC_2014 4013930 200 µM 0.358602775077281 0.343419318226874 no 1113 0.359946135243901 1752 64556 SGTC_2628 lathosterol 100 µM 0.35857086573145 0.343432409549071 no 1114 0.359958072546298 1692 6710616 SGTC_81 0411-0046 9.971 µM 0.357589706842421 0.343835037375157 no 1115 0.360325191198554 1659 12925265 SGTC_1952 st077036 64.1 µM 0.355343710230739 0.344757369701987 no 1116 0.361166056643341 1661 2937007 SGTC_285 1486-1325 46 µM 0.355343295784303 0.344757539982347 no 1117 0.361166211867569 1755 22310230 SGTC_463 ikarugamyin 104 µM 0.354846651444425 0.344961614941589 no 1118 0.361352238415375 1733 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3316 9136639 10.545 µM 0.354285773174821 0.345192138348118 no 1119 0.361562364289056 1756 4903665 SGTC_1242 0402-0103 60.1 µM 0.35381097164689 0.34538732874832 no 1120 0.361740275251536 1673 432868 SGTC_1968 st069590 43.6 µM 0.35313449219838 0.345665499756186 no 1121 0.361993807754596 1776 6384066 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.352600245260473 0.345885243110748 no 1122 0.362194076847959 1733 1609 A potent and irreversible inhibitor of serine proteases. SGTC_728 3030-5151 22.5 µM 0.351384901309931 0.346385324642661 no 1123 0.362649804068353 1721 3125388 SGTC_2204 7233102 200 µM 0.349918030611277 0.346989259464589 no 1124 0.363200107487427 1758 2172480 SGTC_74 000s-0487 160.283 µM 0.349360414741887 0.347218941199272 no 1125 0.363409373866536 1675 677548 SGTC_2564 betulinic acid 100 µM 0.349180926423937 0.347292884304161 no 1126 0.363476742301868 1908 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1116 jasmonic acid  1.58368 µM 0.349042697779123 0.347349833784072 no 1127 0.363528627372792 1765 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2057 5236571 38.335 µM 0.348036840696248 0.347764345363889 no 1128 0.363906258067614 1815 54684039 YBR257W POP4 SGTC_92 0063-0024 660.874 µM 0.348013635982593 0.347773910127453 no 1129 0.363914971415732 1765 3594437 SGTC_2231 micatex 6.853 µM 0.347355222782014 0.348045342177078 no 1130 0.364162234260169 1734 20737 An antifungal of unknown mechanism. SGTC_333 3486-0131 40.1 µM 0.346407723654704 0.348436087069348 no 1131 0.364518160697066 1837 6744690 SGTC_2614 arthonioic acid 13.39 µM 0.34605723212455 0.34858066917844 no 1132 0.364649851864284 1635 6710684 SGTC_698 k064-0052 127 µM 0.34554957858033 0.348790121571658 no 1133 0.36484062227657 1758 5088751 SGTC_2172 5754775 163.918 µM 0.345506174339738 0.348808031834329 no 1134 0.364856934648856 1646 2263357 SGTC_2080 5212524 12.4 µM 0.345013809218143 0.349011224240917 no 1135 0.365041994591198 1847 260183 SGTC_2451 5856223 45.7 µM 0.343251913090917 0.349738689227169 no 1136 0.36570447666086 1665 2179896 SGTC_2893 9048488 25.97 µM 0.342035203937537 0.35024137571616 no 1137 0.366162199655592 1631 6467338 SGTC_880 0833-0487 87.2 µM 0.341591867065442 0.350424606766733 no 1138 0.366329029288208 1672 76075 SGTC_1980 st071811 45.7 µM 0.340725070494763 0.35078295417376 no 1139 0.366655281651389 1793 4974850 SGTC_2643 anethole 100 µM 0.340717760429984 0.350785976835199 no 1140 0.366658033486661 1728 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.339850957622823 0.351144460735424 no 1141 0.366984385379407 1669 4174840 SGTC_578 3460-0051 92 µM 0.339500100092802 0.351289602679747 no 1142 0.367116510845717 1856 2876744 SGTC_1424 4048-1941 275 µM 0.339325730754244 0.351361743460781 no 1143 0.367182180477106 1837 X1424 SGTC_2364 9055074 200 µM 0.33815480905378 0.351846320483405 no 1144 0.367623264518271 1661 6470630 SGTC_1323 1348-1351 11.2 µM 0.338011398313093 0.351905686490527 no 1145 0.367677299097574 1698 6989654 SGTC_1892 st058411 7.36 µM 0.337440636522989 0.352141993601437 no 1146 0.367892377788562 1810 3934738 SGTC_1304 1165-0502 251 µM 0.33725368093085 0.352219409479176 no 1147 0.367962836791793 1757 767425 SGTC_857 0438-0306 1.35 µM 0.336609087971096 0.352486373976472 no 1148 0.368205802209675 1734 4686136 SGTC_1738 st035555 74 µM 0.336461576073263 0.352547477700235 no 1149 0.368261411055543 1732 5331140 SGTC_2785 7756463 72.73 µM 0.336436970069372 0.352557670593928 no 1150 0.368270687263926 1657 2201551 SGTC_1784 st039334 36.3 µM 0.335073282024356 0.353122735751136 no 1151 0.368784903439435 1825 3496984 SGTC_2175 5807670 165.306 µM 0.333896114118595 0.353610774053585 no 1152 0.369228976083444 1815 241186 SGTC_2642 cholecalciferol 100 µM 0.331999502097308 0.354397590507545 no 1153 0.369944817486871 1785 9821465 A vitamin D precursor, similar to steriods. SGTC_2847 9005661 71.43 µM 0.331931665459029 0.354425744323687 no 1154 0.369970429546731 1752 2991449 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.330469579823858 0.355032737693265 no 1155 0.370522587235675 1769 2724278 An inhibitor of dopamine biosynthesis. SGTC_584 0986-0246 15.4 µM 0.327946431566991 0.356081102417598 no 1156 0.371476083000985 1782 53315 YDR232W HEM1 SGTC_3002 9075603 71.4286 µM 0.326739990210015 0.356582762529535 no 1157 0.37193227551568 1749 20105405 SGTC_1419 3993-2473 62.6 µM 0.326703262295414 0.356598038557416 no 1158 0.371946166291892 1767 704026 SGTC_2817 7995342 71.43 µM 0.325980985221417 0.356898497774535 no 1159 0.372219370814232 1643 18879975 SGTC_233 rapamycin 362 pM 0.325578038947544 0.357066157532806 no 1160 0.372371815002899 1774 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2224 6650123 117.647 µM 0.325508255742072 0.357095196058515 no 1161 0.372398217686796 1743 2908370 SGTC_456 gingerol 170 µM 0.324140299476676 0.357664603628658 no 1162 0.372915908987134 1771 442793 A herb. SGTC_3285 9112818 20.8695 µM 0.324127695111228 0.357669851632309 no 1163 0.372920680069837 1750 17017947 YPR165W RHO1 SGTC_54 0159-0055 9 µM 0.323388735698415 0.357977574710898 no 1164 0.373200429623883 1862 3319099 SGTC_2693 st077581 40.7 µM 0.321657543598764 0.35869885196485 no 1165 0.37385607253127 1787 25238761 SGTC_215 1287-0124 461.5 µM 0.321196791557078 0.358890902997408 no 1166 0.37403063170255 1867 5560863 SGTC_2087 5276107 200 µM 0.320358103395557 0.359240577208741 no 1167 0.37434844093783 1709 144405 SGTC_614 0462-0418 107 µM 0.319195596516129 0.359725456126872 no 1168 0.37478909796407 1739 5188303 SGTC_3348 9149464 3.537 µM 0.318943080633599 0.359830809802233 no 1169 0.374884837658362 1745 1951442 SGTC_174 3553-0389 74.3 µM 0.316834255862116 0.3607110605107 no 1170 0.375684684921595 1791 738071 SGTC_1815 st051655 58.2 µM 0.315132657318013 0.361421868353746 no 1171 0.376330466927103 1873 5984156 SGTC_2511 berberine 10.47 µM 0.31479292623902 0.361563841427437 no 1172 0.376459441469983 1727 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1180 1193-0155 285 µM 0.313184688863107 0.362236179648975 no 1173 0.37707017512321 1724 2921347 SGTC_3078 9116413 49.47 µM 0.312526481381118 0.362511472007203 no 1174 0.377320220484293 1720 17177322 SGTC_3176 9106582 49.47 µM 0.311905995000765 0.362771052793223 no 1175 0.377555983143474 1862 17018027 SGTC_719 2810-4230 27.3 µM 0.311411265706871 0.362978068242697 no 1176 0.377743995302913 1783 721079 SGTC_3124 9127567 49.47 µM 0.311069976676926 0.363120901206558 no 1177 0.37787371238843 1859 17592030 SGTC_2786 7743617 45.45 µM 0.310191986015652 0.363488436763639 no 1178 0.378207482207758 1680 583674 SGTC_2813 7971799 71.43 µM 0.309676507524148 0.36370427973046 no 1179 0.378403484708326 1782 2234054 SGTC_600 1495-0418 41.6 µM 0.308847775540081 0.364051379965555 no 1180 0.378718662440051 1773 5377768 SGTC_1548 st061468 90.8 µM 0.308501723328029 0.364196351057608 no 1181 0.378850294562066 1867 390799 SGTC_846 0335-0850 148 µM 0.307144321334842 0.364765192716552 no 1182 0.379366761742041 1799 6819598 SGTC_1514 1189-1591 158 µM 0.306165348125202 0.365175632507072 no 1183 0.379739377263296 1844 767698 YMR146C TIF34 SGTC_1478 0453-0656 35.7 µM 0.305424824007841 0.365486203891971 no 1184 0.380021308818927 1796 5258496 SGTC_1936 st074407 74.3 µM 0.30509677892947 0.365623812242154 no 1185 0.38014622218396 1700 809813 SGTC_3142 9086498 49.47 µM 0.305005268599569 0.365662202081536 no 1186 0.380181069818656 1920 25236367 SGTC_3231 9132313 49.47 µM 0.304750105072345 0.36576925378887 no 1187 0.380278242623351 1792 4905967 SGTC_2552 juarezic acid 87.02 µM 0.303977612212437 0.366093410356876 no 1188 0.380572473728624 1774 1549512 SGTC_2477 5967686 25.23 µM 0.30367154658192 0.366221869304808 no 1189 0.380689068721878 1727 776118 SGTC_304 1310-0298 97 µM 0.302685568686657 0.366635796432504 no 1190 0.381064748357342 1783 1550234 SGTC_2772 vinpocetine 57.06 µM 0.301833700795988 0.366993547286505 no 1191 0.381389419386862 1846 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1955 wogonin 32.4 µM 0.30048367567722 0.367560741018905 no 1192 0.381904123191069 1870 5281703 A flavanone. SGTC_2876 9059903 25.97 µM 0.298624230787173 0.368342433160035 no 1193 0.382613387555281 1790 6916095 SGTC_2247 cerulenin 830 nM 0.29795769050864 0.368622773000749 no 1194 0.382867727890358 1864 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_931 2812-0076 566 µM 0.295591322553785 0.369618606457061 no 1195 0.383771100632551 1753 3450959 SGTC_1865 st057639 52.2 µM 0.295542741249863 0.369639060011829 no 1196 0.383789653424655 1816 688818 SGTC_2235 salicylic acid 500 µM 0.295302907492652 0.36974003950502 no 1197 0.383881247825812 1834 338 A COX inhibitor and kinase inhibitor. SGTC_882 0843-0131 351 µM 0.295149077930083 0.369804812561639 no 1198 0.383939999962732 1916 5425421 SGTC_512 prima-1 270 µM 0.295103708617499 0.36982391693619 no 1199 0.383957328377304 1868 322968 A re-activator of the apoptotic function of mutant p53. SGTC_446 go6976 132 µM 0.294859569440248 0.369926725998932 no 1200 0.384050579196375 1912 3501 A protein kinase C inhibitor. SGTC_1023 4482-3888 16 µM 0.294544160764239 0.370059561010423 no 1201 0.384171061881473 1880 3303168 SGTC_3279 9140807 49.47 µM 0.294079838439232 0.370255139515476 no 1202 0.384348448326711 1781 45595718 SGTC_3070 9117005 49.47 µM 0.292997137624473 0.370711317195759 no 1203 0.384762169789841 1858 8779016 SGTC_1553 gossypol 38.6 µM 0.292585704593082 0.370884715253475 no 1204 0.384919420956771 1812 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_630 4356-0227 183 µM 0.291918944002693 0.371165776536429 no 1205 0.385174299412125 1805 779312 SGTC_3023 9089636 49.47 µM 0.291818350717795 0.371208185849336 no 1206 0.385212756896059 1905 17249241 SGTC_1614 st002383 48.6 µM 0.291263681878119 0.371442057806792 no 1207 0.385424830758846 1814 1947235 SGTC_78 0336-0123 156.75 µM 0.291000282189826 0.371553134939155 no 1208 0.385525551843087 1722 6765896 SGTC_1703 st026983 48.3 µM 0.290813055572355 0.371632095962678 no 1209 0.385597149894718 1905 1104023 SGTC_235 0330-0087 5 mM 0.290259285803458 0.371865674633727 no 1210 0.385808941933189 1787 46494818 YHR062C RPP1 SGTC_3151 9099821 49.47 µM 0.289451029271301 0.372206679819081 no 1211 0.386118124809363 1749 17174189 SGTC_3116 9124943 49.47 µM 0.288860357227413 0.372455949047735 no 1212 0.386344120717181 1695 41905195 YPL160W CDC60 SGTC_507 nimesulide 162 µM 0.287926196981633 0.372850282621224 no 1213 0.386701616685696 1920 4495 A COX2 inhibitor. SGTC_784 4579-0127 173 µM 0.286567076496941 0.373424240987276 no 1214 0.387221913345287 1938 1948547 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.286272228451619 0.37354879282998 no 1215 0.387334813458941 1788 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3128 9127691 49.47 µM 0.285101293883853 0.374043557757205 no 1216 0.387783269398171 1819 41316314 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.284631971200167 0.374241922973818 no 1217 0.387963057243013 1789 115019 SGTC_17 0960-0276 49.807 µM 0.28310243414583 0.374888632160424 no 1218 0.38854915785786 1826 6821114 SGTC_2567 aureobasidin a 60 nM 0.282064499822721 0.375327685565329 no 1219 0.388947026739056 1831 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1060 3448-7350 82 µM 0.281943750449443 0.375378773887259 no 1220 0.38899332087989 1917 570178 SGTC_510 ag-490 170 µM 0.281499468745856 0.375566765570648 no 1221 0.389163667747394 1914 5328779 SGTC_2236 dapsone 200 µM 0.280914605990458 0.375814287235469 no 1222 0.389387948800846 1923 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_428 3448-4153 16.5 µM 0.280482251871813 0.375997298088096 no 1223 0.389553770088356 1710 3834874 SGTC_1855 st056195 39.6 µM 0.277149061026801 0.377409135506013 no 1224 0.390832825712044 1941 4028379 SGTC_2309 7664088 163.95 µM 0.277123418618963 0.377420003223854 no 1225 0.390842670151329 1980 704922 SGTC_430 0958-0115 16.4 µM 0.2760027442592 0.377895060066239 no 1226 0.391272979230601 1799 6833180 SGTC_1764 st044502 93.5 µM 0.275023066219125 0.378310499545231 no 1227 0.391649258549313 1817 8407 SGTC_33 0986-0033 35.816 µM 0.274073121783703 0.378713464660883 no 1228 0.392014214476159 1870 2848082 SGTC_2845 9003024 42.97 µM 0.273736918486566 0.378856113257465 no 1229 0.392143402063098 1899 2990173 SGTC_3310 9130229 44.1445 µM 0.273022509095819 0.379159286700767 no 1230 0.392417956454247 1909 7761258 SGTC_108 0509-0257 621.132 µM 0.272067305493236 0.379564761949508 no 1231 0.392785134027747 1912 536624 SGTC_2474 5321570 43.32 µM 0.271968670527619 0.379606639150004 no 1232 0.39282305447201 1921 2841384 SGTC_585 0kpi-0023 191 µM 0.271661080804694 0.379737240815739 no 1233 0.392941314594527 1915 64601 SGTC_252 miconazole 1.30953 nM 0.270570206538052 0.380200533246176 no 1234 0.393360806532672 1880 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1294 1000-1494 117 µM 0.270196316105091 0.380359363469367 no 1235 0.393504613328332 1782 712797 YDL207W GLE1 SGTC_318 1488-0629 67.2 µM 0.268113865730812 0.381244365510985 no 1236 0.394305836569717 1809 3662576 SGTC_791 1348-1292 225 µM 0.267175618261247 0.381643306292851 no 1237 0.394666973906332 1921 5437054 SGTC_2239 6685329 187.64 µM 0.266509633647089 0.381926557840328 no 1238 0.394923370521741 1795 805680 SGTC_986 1493-0483 84 µM 0.26637780802303 0.381982632419501 no 1239 0.39497412730947 1949 40079 SGTC_2244 6635614 200 µM 0.265152184502257 0.382504093466793 no 1240 0.395446114044783 1835 836499 SGTC_898 1000-0849 28.3 µM 0.264915860918217 0.382604665637303 no 1241 0.3955371397492 1959 6751807 SGTC_3172 9105863 49.47 µM 0.264252751940238 0.382886907022278 no 1242 0.395792582513441 1888 2348785 SGTC_951 1171-0579 82.7 µM 0.263404350975436 0.383248105559027 no 1243 0.396119468696577 1792 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2689 tacrolimus 100 µM 0.263350755132464 0.383270926885123 no 1244 0.396140121459486 1823 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_744 1594-0068 283 µM 0.262734191657857 0.383533491214334 no 1245 0.396377730600154 1816 668392 SGTC_3115 9123671 49.47 µM 0.262070784250953 0.383816063832836 no 1246 0.39663343528618 1951 3286988 SGTC_2383 9036125 200 µM 0.261349507579255 0.384123355467598 no 1247 0.396911495626967 1866 79580 SGTC_3311 9131146 2.8755 µM 0.260932845226797 0.384300902886063 no 1248 0.397072147587705 1850 4900406 YPR165W RHO1 SGTC_3168 9103419 49.47 µM 0.260664254788343 0.384415367036443 no 1249 0.397175716914015 1948 16649256 SGTC_223 busulfan 5 mM 0.260544830167401 0.384466265003867 no 1250 0.397221769756539 1919 2478 A DNA alkylator. SGTC_147 4466-0538 29.23 µM 0.26044281841846 0.384509743300189 no 1251 0.397261108935504 1863 6742687 YHR072W ERG7 SGTC_1964 st076914 61 µM 0.260319196285508 0.384562434077532 no 1252 0.39730878320982 1888 24208661 SGTC_668 1682-0499 62.6 µM 0.260299933525988 0.38457064452895 no 1253 0.397316211937516 1839 682214 SGTC_2351 9026858 72.31 µM 0.260239298056745 0.384596489791915 no 1254 0.397339596389423 1773 1409300 SGTC_1724 st037281 8.293 µM 0.259502542503517 0.384910565433761 no 1255 0.397623760281689 1786 574124 YDL195W SEC31 SGTC_2677 mitomycin C 100 µM 0.259419957254708 0.384945775872509 no 1256 0.397655616496012 1851 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2056 5235370 200 µM 0.25766094363114 0.38569596085589 no 1257 0.398334295490773 1806 5511916 SGTC_1372 2752-0194 270 µM 0.256728611276062 0.386093756041685 no 1258 0.398694141508523 1845 823334 SGTC_180 1486-1293 102.781 µM 0.255171875400724 0.386758230219755 no 1259 0.399295176184161 2017 4140536 SGTC_1513 0337-0559 19 µM 0.254629435752666 0.386989842247505 no 1260 0.399504660969833 1781 775073 SGTC_511 blebbistatin 171 µM 0.253937870152683 0.387285186744743 no 1261 0.399771778666535 1945 3476986 A myosin inhibitor. SGTC_177 1327-0068 8.361 µM 0.253794910607027 0.387346248121534 no 1262 0.399827002746347 1897 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1926 methyl fluorone black 53.6 µM 0.253527176254784 0.387460611243018 no 1263 0.399930431682273 1876 72721 Reacts with homocysteine. SGTC_1093 fluphenazine 7.97 µM 0.253481143171801 0.387480275326185 no 1264 0.399948215512327 1878 6602611 An atypical antipsychotic. SGTC_400 oxethazaine 37.5 µM 0.251813983669034 0.388192634762062 no 1265 0.400592424071565 1845 4621 A local anesthetic. SGTC_15 0266-0086 27.098 µM 0.251296944561044 0.388413636612563 no 1266 0.400792268637951 1986 1712902 YIL048W NEO1 SGTC_2902 5787006 60.46 µM 0.251136786389662 0.388482101537094 no 1267 0.400854177813908 1817 591003 SGTC_2658 polymyxin b sulfate 77.05 µM 0.250847498631904 0.388605775967991 no 1268 0.400966008369593 1862 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2052 5265182 7.135 µM 0.250675927285887 0.388679130375523 no 1269 0.401032336887507 1952 1239884 SGTC_2661 dactinomycin 12.96 µM 0.25043319054176 0.388782917947174 no 1270 0.401126182420967 1884 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_998 3996-0085 177 µM 0.25035529687901 0.388816224822981 no 1271 0.401156298446096 1950 715391 SGTC_1301 naphtanilide LB 4.81 µM 0.249526017557616 0.389170870443157 no 1272 0.401476959067613 1957 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1512 0259-0544 12.2 µM 0.249477083088416 0.389191800412024 no 1273 0.401495882822301 1892 18476 SGTC_2203 7227154 166.4 µM 0.249402749427839 0.38922359459162 no 1274 0.401524629299163 1898 896304 SGTC_448 monastrol 171 µM 0.249401466875654 0.389224143174564 no 1275 0.401525125295245 1933 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3160 9100216 49.47 µM 0.247710406923025 0.389947647835286 no 1276 0.402179239610624 1986 17191039 SGTC_3112 9123419 49.47 µM 0.24725603623337 0.390142111332135 no 1277 0.402355040289725 1916 17015854 SGTC_751 0833-0568 350 µM 0.247000857704041 0.390251335782056 no 1278 0.402453780142798 1884 6954252 SGTC_2818 7996756 12.99 µM 0.246576435460214 0.390433021058289 no 1279 0.40261802165164 1838 2241621 SGTC_2192 5915882 198.485 µM 0.245933749921897 0.390708185307234 no 1280 0.40286675867716 1883 2876149 SGTC_2163 5671233 125 µM 0.24389109701605 0.391583105016376 no 1281 0.403657582283308 1974 701023 SGTC_2165 5727197 32.143 µM 0.243024589465013 0.3919544180477 no 1282 0.403993174371827 1899 1361712 SGTC_279 1273-0055 2.93 µM 0.242355054738274 0.392241392344812 no 1283 0.404252528730758 2005 2847562 SGTC_2237 6667747 47.222 µM 0.242313549840375 0.392259184001215 no 1284 0.404268607664494 1820 729940 YDL015C TSC13 SGTC_2065 5221596 34.26 µM 0.241680527626345 0.392530565740884 no 1285 0.404513859524486 1908 788581 SGTC_148 3253-0744 288.01 µM 0.240942746245391 0.392846924529341 no 1286 0.404799745584911 1922 6893655 SGTC_672 1441-0018 53.7 µM 0.23991144134308 0.393289264067688 no 1287 0.405199455473789 1841 251141 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.239907227690125 0.393291071639025 no 1288 0.405201088791219 1901 91467 include heat shock SGTC_1348 1493-0373 93.8 µM 0.239842476660105 0.39331884880195 no 1289 0.405226188119959 1924 3010129 SGTC_3241 9133421 49.47 µM 0.237600722453711 0.394280859660491 no 1290 0.406095395061525 1962 17018221 SGTC_1618 st003135 44.5 µM 0.237292633651154 0.394413121317795 no 1291 0.406214888213253 1981 1270615 SGTC_2468 5987765 72.9 µM 0.236564975215585 0.394725551346365 no 1292 0.406497147349817 1919 26772094 SGTC_2794 7785382 27.27 µM 0.236115091592557 0.394918748877717 no 1293 0.406671681789974 2055 2205081 SGTC_462 ag-879 158 µM 0.236105125404254 0.394923029039461 no 1294 0.406675548429032 1987 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3134 9127454 49.47 µM 0.235812161193941 0.395048853538001 no 1295 0.406789215492008 1985 24262820 SGTC_2894 9048625 32.47 µM 0.235594779957746 0.395142223160111 no 1296 0.406873562223832 2004 4092861 SGTC_2277 7947813 106.88 µM 0.235245993346019 0.395292046617906 no 1297 0.407008904965776 1974 1246798 SGTC_477 mead ethanolamide 10 µM 0.233433380300942 0.396070914604263 no 1298 0.407712447649071 1967 16061185 SGTC_3223 9129970 49.47 µM 0.233418259164765 0.396077413807727 no 1299 0.40771831798096 1901 17248386 SGTC_1822 st052468 42 µM 0.23316323294518 0.396187030774044 no 1300 0.407817327454701 1884 2873678 SGTC_187 1488-2104 32.728 µM 0.231841855273434 0.396755124860778 no 1301 0.408330423393812 1979 2852859 SGTC_3059 1327-0034 3 µM 0.23156132180483 0.396875761629576 no 1302 0.408439375858806 1846 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2558 carylophyllene oxide 100 µM 0.230667718780852 0.397260100166917 no 1303 0.408786476963793 1992 6708694 An oxygenated terpenoid and antifungal agent. SGTC_284 0988-0104 32.6 µM 0.228081019794688 0.398373200273149 no 1304 0.409791627625205 1988 4666532 SGTC_2489 cantharidin 73.42 µM 0.227525965645987 0.398612157542598 no 1305 0.410007390480669 1821 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1511 0906-3109 28.5 µM 0.226548258797959 0.399033164123541 no 1306 0.410387514810345 1956 2882180 SGTC_479 n-linoleoylglycine 10 µM 0.225432103300719 0.399513931137189 no 1307 0.410821569745267 1893 6433346 An anti-infammatory. SGTC_1777 st045864 34.765 µM 0.22508211646863 0.399664714067637 no 1308 0.410957696518864 1958 4691462 SGTC_1046 2001-0062 216 µM 0.224094118686851 0.400090448478507 no 1309 0.411342034363481 1855 739778 SGTC_805 3852-0218 479 µM 0.223986455948631 0.40013684820961 no 1310 0.411383921048144 1852 6615355 SGTC_1236 0330-0013 258 µM 0.223794944072808 0.400219388137175 no 1311 0.411458432122544 1885 4617066 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.223442583831045 0.400371263932194 no 1312 0.411595532433197 1868 6312947 SGTC_1269 0831-0796 3.05 µM 0.222993970973636 0.400564648733855 no 1313 0.411770099419215 1996 927758 SGTC_1238 0333-0287 48.8 µM 0.221634538936229 0.401150811579549 no 1314 0.412299196457141 1903 7226 SGTC_1300 1094-0077 113 µM 0.221252776734472 0.401315460715226 no 1315 0.412447808730257 1883 5532636 SGTC_2378 9074213 121.43 µM 0.220086958182751 0.401818371643866 no 1316 0.412901715832504 1981 657714 SGTC_785 1270-0111 65.3 µM 0.219780326260254 0.40195067360065 no 1317 0.413021121198146 2007 6741994 SGTC_390 dec-rvkr-cmk 16.7 µM 0.219285643640658 0.402164137153237 no 1318 0.413213772239359 1944 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1028 k015-0029 4.8 µM 0.219168346540459 0.402214757032051 no 1319 0.413259455925762 1871 4588309 SGTC_549 1661-1316 519 µM 0.217977649021519 0.402728698426851 no 1320 0.413723263102102 2028 2857282 SGTC_2388 9080168 200 µM 0.216451099746051 0.403387849546409 no 1321 0.41431806917454 1837 15943073 SGTC_2233 sulbentine 40.3845 µM 0.216374618076241 0.403420880925157 no 1322 0.414347874745042 1982 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_204 PMA1.184 62.41 µM 0.216086151115451 0.403545472026701 no 1323 0.414460297260471 1942 2252213 YGL008C PMA1 SGTC_533 1222-0222 6.71 µM 0.215301248570738 0.403884527000589 no 1324 0.414766228117641 2015 3982874 SGTC_2987 9018338 71.43 µM 0.215188892516252 0.40393306745006 no 1325 0.414810025284547 1962 5055682 SGTC_2514 salinomycin 42.74 µM 0.214357605038977 0.404292249044131 no 1326 0.415134099756644 2052 23682228 A polyether potassium ionophore. SGTC_2123 5259487 200 µM 0.213750589015171 0.404554578715286 no 1327 0.415370779293978 1994 2173474 SGTC_1645 Cervolide 78 µM 0.213532098870135 0.404649012510401 no 1328 0.415455977558459 1912 23173 A fragrance. SGTC_1454 4239-0054 42.6 µM 0.213148954724494 0.404814624945792 no 1329 0.415605390762391 2043 1340767 SGTC_3046 9092212 49.47 µM 0.212957389064142 0.404897434787603 no 1330 0.415680099440788 1961 25236637 SGTC_1054 3429-0080 167 µM 0.211702115083875 0.405440168792357 no 1331 0.416169718951641 1998 1162877 SGTC_1636 st007707 68.9 µM 0.211179339486498 0.405666251311525 no 1332 0.416373665954302 2022 403051 SGTC_1122 capsaicin 818.572 nM 0.210979070576724 0.405752869089062 no 1333 0.416451801513927 1972 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_299 1273-0059 1.44 µM 0.20982018803518 0.406254184802581 no 1334 0.416904008000788 2030 2848077 SGTC_2432 5630864 12.22 µM 0.209732544811129 0.406292104247846 no 1335 0.416938211662502 1916 5714970 SGTC_2575 plumbagin 510 nM 0.209232799296655 0.406508339374789 no 1336 0.417133254450418 1857 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3062 9077494 49.47 µM 0.207822213821601 0.407118839899143 no 1337 0.417683893578552 1997 16459633 SGTC_1215 3852-0577 11.2 µM 0.207536240250431 0.407242636652531 no 1338 0.417795546543193 2020 2884876 SGTC_760 0568-0725 82.9 µM 0.204434017515469 0.408586168761264 no 1339 0.419007174666968 2070 3916171 SGTC_1665 st014639 11.4 µM 0.204356553650195 0.40861973117146 no 1340 0.419037439436771 2002 981133 YIL048W NEO1 SGTC_1884 5633444 25 µM 0.203686038166755 0.408910270291691 no 1341 0.419299426702655 1973 5724239 SGTC_703 3875-0075 71.8 µM 0.20274303176642 0.409318966333833 no 1342 0.419667943549331 1961 2850814 SGTC_2018 5133068 143 µM 0.201630425892948 0.409801293002603 no 1343 0.42010282864893 1937 785362 SGTC_1435 4092-0789 56.7 µM 0.201607900725239 0.409811059318626 no 1344 0.420111634087696 2042 2248285 SGTC_554 4483-2211 187 µM 0.201180235399613 0.409996494284553 no 1345 0.42027882270406 1952 747107 SGTC_125 0133-0007 11.75 µM 0.200500827362512 0.410291125842777 no 1346 0.42054445549615 2083 26541 SGTC_772 k072-0172 35.3 µM 0.200475939888248 0.41030191948794 no 1347 0.420554186609422 1831 5861980 SGTC_1985 st071382 65.5 µM 0.199756360908343 0.410614028727921 no 1348 0.420835566167981 1955 6123237 SGTC_2301 7769476 200 µM 0.199449456411973 0.410747162313354 no 1349 0.420955588450704 1971 977820 SGTC_628 1636-0253 16 µM 0.19621870565112 0.412149266358806 no 1350 0.42221949382527 2055 4456143 SGTC_2517 totarol 10 µM 0.196098478191696 0.412201465287188 no 1351 0.422266543681645 1896 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2217 6934799 96.0675 µM 0.195575397539139 0.412428588291857 no 1352 0.422471259152148 2066 675606 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.195304249576437 0.412546333001808 no 1353 0.42257738522578 2075 5024745 SGTC_1904 st060225 78 µM 0.195174867345788 0.412602519392937 no 1354 0.422628026820824 2003 66595 SGTC_776 4476-4378 112 µM 0.193984558055549 0.413119514935027 no 1355 0.423093986561875 1912 2892008 SGTC_1169 aniline yellow 25.8 µM 0.193506162385725 0.413327342452684 no 1356 0.423281290189365 1994 6051 A DNA damaging agent. SGTC_2119 5528445 120.635 µM 0.193002674811601 0.413546096777269 no 1357 0.423478436639515 2054 791935 SGTC_473 2-arachidonoylglycerol 10 µM 0.191445849908946 0.414222672598191 no 1358 0.42408815063867 1907 5282280 An endocannabinoid. SGTC_20 0481-0013 4.944 µM 0.190305114133109 0.414718583267045 no 1359 0.424535023192877 1928 182045 SGTC_794 k038-0031 316 µM 0.188692279211825 0.415419960831343 no 1360 0.425167001591713 2007 6624242 SGTC_1933 st074711 15.9 µM 0.188670275154789 0.415429531659884 no 1361 0.425175625065557 2091 17250958 SGTC_522 1273-0010 11.6 µM 0.187970615168775 0.415733880116848 no 1362 0.425449843127084 1986 5705015 SGTC_2323 6148992 148.28 µM 0.187689757934215 0.415856065783476 no 1363 0.425559929784716 1938 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_904 1141-0088 396 µM 0.186067414556024 0.416562017765748 no 1364 0.426195947534056 1886 1378119 SGTC_1480 1070-0044 41.2 µM 0.184612216085819 0.41719546685364 no 1365 0.426766601797948 2079 3124987 SGTC_2350 9023895 38.85 µM 0.184447729211604 0.417267081679668 no 1366 0.426831114787074 2010 2997209 SGTC_1295 1013-0063 9.78 µM 0.184349097921429 0.417310025405546 no 1367 0.426869799659676 2104 6826038 SGTC_1252 0493-0875 34.8 µM 0.183902280022918 0.417504580736668 no 1368 0.427045058058541 1963 3960963 SGTC_676 falcarinol 140 µM 0.183558962953182 0.417654083024838 no 1369 0.427179729414901 2091 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1612 st002233 45.4 µM 0.182450227065818 0.418136978980407 no 1370 0.427614705860475 2090 1035021 SGTC_1209 2323-2347 50.3 µM 0.182245391555941 0.418226206037422 no 1371 0.427695076053146 2118 5412760 SGTC_291 SEC14.278 35.5 µM 0.181793922927464 0.418422882188507 no 1372 0.427872226927741 2069 1068044 SGTC_813 k007-0158 173 µM 0.180733341470973 0.418884990191857 no 1373 0.428288443507773 2053 6523916 SGTC_380 3970-0968 6 µM 0.180446416631006 0.419010026035283 no 1374 0.428401058562879 1965 2891601 SGTC_1400 3771-8998 51.5 µM 0.17981511023199 0.419285164943356 no 1375 0.428648860361204 2037 670767 SGTC_686 1319-0111 510 µM 0.17901395178306 0.419634386382373 no 1376 0.428963373356363 2071 4562600 SGTC_392 N-ethylmaleimide 8.33 µM 0.178387012162481 0.419907710767036 no 1377 0.429209524254981 1951 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_965 1291-5240 308 µM 0.17787299135251 0.420131835216256 no 1378 0.429411361177752 2063 2834598 SGTC_766 1391-0721 126 µM 0.177444233519972 0.420318802937059 no 1379 0.429579732608237 2075 1020919 YIL115C NUP159 SGTC_1154 4088-0362 150 µM 0.177019026128039 0.42050424018128 no 1380 0.429746722447046 2081 6618304 SGTC_1558 st069300 45.6 µM 0.176798315706061 0.42060050118731 no 1381 0.429833406042933 2099 24208000 SGTC_2843 9000894 45.46 µM 0.176774840902083 0.420610739806351 no 1382 0.429842625926365 2056 2242070 SGTC_93 0109-0045 59.227 µM 0.174432131564097 0.421632789808366 no 1383 0.430762932022873 2120 88733 SGTC_1562 morin hydrate 59.1 µM 0.174102578646604 0.421776605856316 no 1384 0.430892423342281 1989 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1502 4534-4282 27.7 µM 0.173700472311988 0.421952098159478 no 1385 0.431050433158267 1992 3278949 SGTC_3037 9091026 49.47 µM 0.172499574059052 0.422476301409097 no 1386 0.431522398096472 2065 25236398 YIL048W NEO1 SGTC_3173 9105693 49.47 µM 0.172492901203017 0.422479214557303 no 1387 0.431525020868935 2053 17096658 SGTC_3154 9100113 49.47 µM 0.172180009010768 0.422615817696176 no 1388 0.431648006832741 1967 25237525 SGTC_2588 indole-3-carbinol 100 µM 0.169690228912408 0.423703141546806 no 1389 0.432626879412161 2108 3712 Induces cell cycle arrest. SGTC_1184 1269-1718 139 µM 0.169360403956393 0.423847224764532 no 1390 0.432756583307374 2102 5403821 SGTC_1461 k072-0203 53.8 µM 0.16808253769308 0.424405553453087 no 1391 0.433259173402427 2124 5418714 SGTC_2752 diclazuril 33.15 µM 0.167369260347254 0.424717266521732 no 1392 0.433539755337709 2123 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2139 5578692 56.4705 µM 0.165009104207368 0.425749025331349 no 1393 0.434468408083844 2138 650991 YMR113W FOL3 SGTC_1627 st003713 25.6 µM 0.164947828814757 0.42577581910276 no 1394 0.43449252300674 1990 16195070 YER133W GLC7 SGTC_2315 7733312 200 µM 0.164901046295723 0.425796275834329 no 1395 0.434510934425187 1987 726316 SGTC_41 0478-0632 82.643 µM 0.164155346087564 0.426122377314267 no 1396 0.434804426411281 2162 3750424 SGTC_936 3005-4620 401 µM 0.163938068508382 0.426217404290055 no 1397 0.434889949082961 2135 777207 SGTC_1349 flufenamic acid 69 µM 0.162035110901051 0.427049850759345 no 1398 0.435639102353389 2025 3371 A non-steroidal anti-inflammatory. SGTC_277 nystatin 15.5 µM 0.161404952246692 0.427325584696472 no 1399 0.435887233242688 2074 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2180 6301957 200 µM 0.161215410768245 0.427408527934075 no 1400 0.435961871921995 2120 845462 SGTC_418 lividomycin a 100 µM 0.160678786885106 0.427643371614524 no 1401 0.436173198968319 2128 72394 An antibiotic. SGTC_36 0335-0881 14.2 µM 0.160348398105802 0.427787973010419 no 1402 0.436303317944825 2037 23828853 SGTC_2904 7225135 42.03 µM 0.160301876318047 0.427808335000302 no 1403 0.436321640450978 2137 4446116 SGTC_1221 2958-7315 257 µM 0.160146254418598 0.42787645010689 no 1404 0.436382932794541 2047 4562705 SGTC_938 3126-1755 342 µM 0.159417759069475 0.428195338267217 no 1405 0.436669874059137 2145 1777771 SGTC_1421 4029-0249 71.4 µM 0.158833064828935 0.428451313535123 no 1406 0.436900198758425 2149 2894095 SGTC_105 0111-0055 734.78 µM 0.157883695385366 0.428867005271323 no 1407 0.437274223056162 2057 5179370 SGTC_1710 st031758 61.5 µM 0.156913052645264 0.429292093338471 no 1408 0.437656686384547 2128 5394341 SGTC_2653 dihydrofissinolide 100 µM 0.156855674417472 0.429317224414479 no 1409 0.437679297012056 2058 6857746 SGTC_1947 st076332 61.6 µM 0.1564799551781 0.42948179266789 no 1410 0.437827359029034 2134 24208416 SGTC_493 zm226600 134 µM 0.154912979763768 0.430168273182579 no 1411 0.438444960403724 2074 5240098 A potassium channel opener. YCR052W RSC6 SGTC_59 0330-0160 1.33 µM 0.154129195175424 0.430511722847907 no 1412 0.438753934450207 2067 4293482 SGTC_814 3342-0569 96 µM 0.154009541581307 0.430564158960816 no 1413 0.438801106126482 2119 4346283 SGTC_3266 9136860 49.47 µM 0.152944247984088 0.431031059276283 no 1414 0.439221120763327 2086 4871271 YPR165W RHO1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.152355350629167 0.431289204527773 no 1415 0.439453335462327 2092 16725076 SGTC_2447 5741742 33.78 µM 0.151831990704836 0.431518645851491 no 1416 0.439659724853417 2074 1776504 SGTC_1330 1469-0054 61.8 µM 0.151822079218739 0.431522991276489 no 1417 0.439663633651921 2161 7102664 SGTC_1472 k841-0093 193 µM 0.150353036463517 0.432167144994806 no 1418 0.440243045732108 2109 X1472 SGTC_2264 7948757 110.76 µM 0.149251532801141 0.432650256625657 no 1419 0.440677579016763 1966 2971411 SGTC_1364 1653-0028 37.6 µM 0.148350051349869 0.433045714907663 no 1420 0.441033258523305 2052 5718652 SGTC_680 0417-1641 114 µM 0.148123184989347 0.433145246313369 no 1421 0.441122776149012 2026 2835990 SGTC_1043 0916-0009 19.3 µM 0.146408349911966 0.433897720005235 no 1422 0.441799518031771 2200 3101130 SGTC_2862 9027634 71.43 µM 0.145771562939344 0.434177204792397 no 1423 0.442050862778408 1960 5012562 SGTC_855 0428-0020 25 µM 0.145524825475294 0.434285506324802 no 1424 0.442148258242419 2021 6812414 SGTC_2289 7946404 165.07 µM 0.145202652893141 0.434426926340448 no 1425 0.442275435714077 2055 1246120 YPR165W RHO1 SGTC_161 4065-0411 162.148 µM 0.145180820797398 0.434436510002644 no 1426 0.44228405413875 2053 1906281 YLR208W SEC13 SGTC_2261 9010538 184.68 µM 0.144557474249795 0.434710157444604 no 1427 0.44253013754698 1992 6457250 SGTC_3118 9124250 49.47 µM 0.143236507968764 0.435290161279415 no 1428 0.44305169894574 2050 1504786 SGTC_2343 7990716 14.84 µM 0.142105681938272 0.435786789876857 no 1429 0.443498265094571 2091 6456862 SGTC_954 1189-0853 2.85 µM 0.140590975021699 0.436452167259085 no 1430 0.444096539154372 2180 2828194 SGTC_1405 3909-7894 12 µM 0.140140285770144 0.436650179923154 no 1431 0.444274575600788 2152 7104060 SGTC_2839 9003951 25.97 µM 0.139517814478319 0.436923692012751 no 1432 0.444520489846149 2222 2990634 SGTC_632 0781-2353 4.65 µM 0.139242396885035 0.437044719338705 no 1433 0.444629303467592 2093 6811515 YHR007C ERG11 SGTC_3258 9138477 49.47 µM 0.138957908708274 0.437169738756231 no 1434 0.444741705130508 2166 4970355 SGTC_742 0kpi-0133 140 µM 0.138879141626858 0.437204354361067 no 1435 0.444772826896618 2139 2728852 SGTC_984 1492-0255 2.91 µM 0.137225179640504 0.43793132820762 no 1436 0.445426404350665 2076 1585198 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.136745781072248 0.438142079837405 no 1437 0.44561587067144 2132 97141 SGTC_491 tetrandrine 80.3 µM 0.136372504118937 0.438306190782628 no 1438 0.445763404560789 2152 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1798 st045719 60.953 µM 0.136177183572961 0.438392067550821 no 1439 0.445840605998741 2157 3980186 SGTC_653 0203-0016 55.2 µM 0.136065880945341 0.438441005379619 no 1440 0.445884599846345 2094 295302 SGTC_2007 4011539 71.82 µM 0.135754195252573 0.438578053161965 no 1441 0.44600780131583 2086 45595301 SGTC_2269 7935389 174.42 µM 0.135645640887816 0.438625786101108 no 1442 0.44605071133465 2051 97605 SGTC_625 k213-0058 121 µM 0.135516522580812 0.438682562468251 no 1443 0.446101750814292 2084 3655420 SGTC_2386 9075165 157.42 µM 0.135235496420542 0.438806140664293 no 1444 0.446212841393077 2079 16452277 SGTC_2690 usnic acid 100 µM 0.134803947104613 0.438995921390339 no 1445 0.446383442494304 2143 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3339 9145883 14.936 µM 0.134120239404589 0.439296621499929 no 1446 0.446653747752844 2156 2030670 SGTC_1935 st074532 41.6 µM 0.132937694067928 0.43981679698529 no 1447 0.447121327948903 2169 2829742 SGTC_2402 5553605 200 µM 0.132390360347007 0.440057592191222 no 1448 0.447337769446497 2130 6758546 SGTC_978 1416-0512 87.4 µM 0.131073599302635 0.440636981623975 no 1449 0.447858542830956 2066 6814003 SGTC_1691 st019933 84.6 µM 0.131010611868134 0.440664699987641 no 1450 0.44788345635285 2191 6176082 SGTC_2734 clemastine 41.6 µM 0.130631706748389 0.440831447785797 no 1451 0.448033329642751 2187 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2731 amoxapine 43.43 µM 0.129937521427467 0.441136970653551 no 1452 0.448307929058205 2215 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2874 9043904 71.43 µM 0.129472194914891 0.441341788458615 no 1453 0.448492012495717 2040 4463428 SGTC_2089 5281248 129.67 µM 0.129362288979423 0.441390166873652 no 1454 0.448535492967941 2089 2737878 SGTC_429 1112-0049 25.5 µM 0.127606964047372 0.442162944160788 no 1455 0.449230009840289 1978 2836170 SGTC_144 4161-2749 112.381 µM 0.127023604055343 0.442419815782488 no 1456 0.449460858268424 2101 797501 YMR168C CEP3 SGTC_2565 isoliquiritigenin 100 µM 0.126478529046409 0.442659851211657 no 1457 0.449676571944463 1909 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2330 7979373 200 µM 0.125480830987037 0.443099263338341 no 1458 0.450071449871202 2020 1863007 SGTC_53 0973-0023 39.979 µM 0.124494116354728 0.443533906919528 no 1459 0.450462029304868 2226 674768 SGTC_1746 st038117 42 µM 0.124043862086618 0.44373226460782 no 1460 0.450640273150318 2081 2898218 SGTC_3091 9116372 49.47 µM 0.120208840090043 0.445422334416346 no 1461 0.452158857589397 2114 17169793 SGTC_868 0527-0199 213 µM 0.119530479873514 0.445721387619 no 1462 0.452427546842754 2072 2849450 SGTC_2415 st077333 57.7 µM 0.119379082930201 0.445788134759219 no 1463 0.452487516090591 2247 2766255 SGTC_652 0437-0092 114 µM 0.118347679768394 0.446242895507967 no 1464 0.452896089914945 2161 3091274 SGTC_1479 0549-0158 134 µM 0.118085702560707 0.446358416378934 no 1465 0.452999875945093 2140 5440202 SGTC_2942 9052777 62.25 µM 0.117529017155833 0.446603906207336 no 1466 0.453220425507989 2129 6469503 SGTC_879 0831-1030 162 µM 0.117282360071474 0.446712684792244 no 1467 0.45331815158828 2156 1549252 SGTC_2886 9058944 51.95 µM 0.117229812616462 0.446735859337057 no 1468 0.453338971371232 2202 4949929 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.116863187104047 0.446897554040005 no 1469 0.453484235323008 2052 641818 YHR062C RPP1 SGTC_550 4123-0385 25.7 µM 0.116160941761884 0.447207293479768 no 1470 0.453762495551394 2107 5731123 SGTC_577 r071-0003 38.6 µM 0.116065974319369 0.447249183257399 no 1471 0.45380012753894 2176 4568517 YMR134W ERG29 SGTC_482 fipronil 114 µM 0.11605227875058 0.447255224369255 no 1472 0.453805554606483 2209 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_702 1488-0190 94 µM 0.11287481724703 0.448657129700691 no 1473 0.455064900820331 2229 949357 SGTC_2962 9082311 13.18 µM 0.112299560514303 0.44891100373336 no 1474 0.455292945129488 2107 16459453 SGTC_2102 5377816 72.7585 µM 0.111999204181667 0.449043566213403 no 1475 0.455412018786291 2202 1379702 SGTC_1265 0819-1001 68.8 µM 0.111931969808367 0.449073240931358 no 1476 0.455438673818122 2206 3106768 SGTC_2595 hexamethylquercetagetin 100 µM 0.111352484896548 0.449329015518697 no 1477 0.455668418608409 2122 386331 SGTC_2214 7179297 48.276 µM 0.110687186329631 0.449622692722872 no 1478 0.455932203682777 2184 769744 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.110641734244504 0.449642757267013 no 1479 0.455950225747989 2155 688761 SGTC_782 0083-0095 30.5 µM 0.11052070541672 0.449696185328265 no 1480 0.45599821495475 2243 3591729 An indicator and reagent. SGTC_3073 9114972 49.47 µM 0.109912525837728 0.449964679411984 no 1481 0.45623937427596 2233 41905075 SGTC_1005 4092-0690 4.4 µM 0.109660053403984 0.450076145586108 no 1482 0.456339491027357 2084 1529343 SGTC_1201 1889-3372 45.9 µM 0.107335957623444 0.45110241402868 no 1483 0.457261229624874 2087 5392199 SGTC_1463 k081-0032 34.1 µM 0.106503238151244 0.451470204141137 no 1484 0.457591543175052 2164 977755 SGTC_1487 3970-0795 2.82 µM 0.106495572340063 0.451473590120698 no 1485 0.457594584096998 2149 3765103 SGTC_2473 5854593 8.94 µM 0.106159635113322 0.451621976652887 no 1486 0.457727848213821 2078 2872951 SGTC_1658 st012944 20 µM 0.105556472887913 0.451888415850187 no 1487 0.457967130669986 2187 24207260 SGTC_1900 st060200 72.8 µM 0.104729696976347 0.452253668721585 no 1488 0.458295148378835 2135 688945 SGTC_250 brefeldin a 552.239 µM 0.104662330764602 0.452283431535784 no 1489 0.45832187671873 2185 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_146 3448-8650 53.125 µM 0.104323310668318 0.452433216804069 no 1490 0.458456389802843 2101 2891488 YIL048W NEO1 SGTC_1115 galangin 695.678 nM 0.103954012017839 0.452596387393443 no 1491 0.458602921929406 2205 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_189 3970-0742 2.116 µM 0.103105510612234 0.452971318788073 no 1492 0.458939615749827 2231 2891807 SGTC_619 1652-1634 108 µM 0.102391365333549 0.453286914106016 no 1493 0.459223018558604 2122 5400454 SGTC_1951 sophoraflavanone G 9.2 µM 0.101602313219512 0.453635646579794 no 1494 0.459536171634989 2092 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_128 0906-2981 13.371 µM 0.100456911917383 0.454141936045108 no 1495 0.4599907945232 2229 6740226 SGTC_224 benfluorex 43.875 µM 0.0997973314969464 0.454433517177503 no 1496 0.460252613316238 2228 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1734 st037168 69.4 µM 0.0996300695785123 0.454507462668685 no 1497 0.460319010258972 2042 708907 SGTC_1167 k781-0610 148 µM 0.0990650271871721 0.454757276166368 no 1498 0.460543319859591 2146 4525169 SGTC_2297 7971671 152.32 µM 0.0986222301692587 0.454953055709591 no 1499 0.460719109471558 2199 909016 SGTC_1726 st035556 14.5795 µM 0.0984464516061249 0.45503077798427 no 1500 0.460788895372437 2208 5919439 SGTC_1496 4469-0713 57.4 µM 0.0973969326980505 0.455494869136223 no 1501 0.461205590250968 2237 746691 SGTC_119 0121-0043 24.815 µM 0.0946245206699995 0.45672110409007 no 1502 0.462306536271887 2234 1092378 SGTC_1613 st002381 52.1 µM 0.0945878805251571 0.45673731277372 no 1503 0.462321088306111 2261 551167 SGTC_349 k015-0014 24 µM 0.0943135325767391 0.456858679729616 no 1504 0.462430050195363 2166 2196908 SGTC_2117 5521686 200 µM 0.0942124877225281 0.45690338130219 no 1505 0.462470182564865 2174 803312 SGTC_3293 9120939 62.045 µM 0.0937157110111379 0.457123159941318 no 1506 0.462667494811632 2202 934087 SGTC_1982 st072467 71.9 µM 0.0936695310800912 0.457143591039722 no 1507 0.462685837253895 2095 3163533 SGTC_123 0083-0120 66.675 µM 0.0928085054673611 0.457524549910287 no 1508 0.463027846896203 2100 16001701 SGTC_369 0957-0393 4.5 µM 0.0926080299895297 0.457613255454933 no 1509 0.463107482078819 2155 6997992 SGTC_1366 1683-0113 21.9 µM 0.0922236642225293 0.457783333901252 no 1510 0.463260168416068 2212 708623 SGTC_1008 4106-0037 6 µM 0.0914003841453148 0.458147654015145 no 1511 0.463587228262321 2242 2905394 SGTC_7 0192-1582 4.227 µM 0.0906811832535153 0.458465945515801 no 1512 0.463872961304632 2203 252616 SGTC_1722 st034304 3.6505 µM 0.0901664754163392 0.458693752376986 no 1513 0.464077462261518 2178 4036148 YLR033W RSC58 SGTC_1186 1319-0216 26 µM 0.0894554154814503 0.459008485899243 no 1514 0.46435999238192 2257 4565136 SGTC_2074 5212007 75.395 µM 0.0887879333150342 0.459303954159352 no 1515 0.464625223817033 2261 758611 SGTC_1088 bifonazole 369 nM 0.0877367654603107 0.459769310589135 no 1516 0.465042948836388 2238 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_465 cgp-37157 41 µM 0.086528270565529 0.460304384434871 no 1517 0.465523241841156 2241 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1820 st053765 18.6 µM 0.0863508116854974 0.460382962300083 no 1518 0.465593773698759 2157 3690829 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0857341715031294 0.460656019361205 no 1519 0.46583886859738 2218 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2304 7443016 91.4 µM 0.0849945624706332 0.460983553242377 no 1520 0.46613285679392 2239 939854 SGTC_2858 9025781 8.96 µM 0.0847101695621835 0.461109502938956 no 1521 0.4662459054447 2263 4894980 YPL153C RAD53 SGTC_1452 4194-0072 190 µM 0.0844189837765712 0.46123846505351 no 1522 0.466361657144906 2247 1343545 SGTC_389 tpck 16.7 µM 0.0843187937355821 0.461282838765551 no 1523 0.466401485185592 2167 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1646 st011709 75.6 µM 0.0841479008638628 0.461358527550746 no 1524 0.466469420141469 2269 5757843 SGTC_212 3807-4682 38.772 µM 0.0839171014984988 0.461460751259631 no 1525 0.466561171245406 2219 3125501 YBL034C STU1 SGTC_3298 9116858 71.43 µM 0.0837656164428851 0.4615278471277 no 1526 0.466621393005863 2221 2506942 SGTC_282 k297-0036 65.7 µM 0.0833708593939575 0.461702698339318 no 1527 0.466778329330076 2226 5061378 SGTC_3060 1327-0027 12.5 µM 0.0831503760281215 0.461800361082707 no 1528 0.466865985110068 2260 16000455 YPR107C YTH1 SGTC_2799 7812892 81.82 µM 0.0811687079749821 0.462678240367122 no 1529 0.467653892398932 2224 20205235 SGTC_1359 1582-0056 520 nM 0.080828603878232 0.462828924938105 no 1530 0.467789129941738 2209 3661189 SGTC_1417 3966-0327 90.4 µM 0.080590146768167 0.462934577560283 no 1531 0.467883951228215 2194 651118 SGTC_3106 9121286 49.47 µM 0.0798738260501568 0.463251971764853 no 1532 0.468168803544243 2238 15943471 SGTC_3136 9095672 49.47 µM 0.0797171215044105 0.463321409032783 no 1533 0.46823112089966 2278 17217380 SGTC_1398 3558-0053 112 µM 0.078156732035242 0.464012893001828 no 1534 0.468851689760946 2193 4532369 SGTC_1138 3761-0006 1.03 µM 0.0775952157495229 0.464261754709967 no 1535 0.469075024093492 2260 12061087 SGTC_2798 7813637 45.45 µM 0.0756579325885058 0.465120457368869 no 1536 0.46984562247622 2221 956368 SGTC_2996 9066192 71.4286 µM 0.0748157500295155 0.465493806509721 no 1537 0.470180655113872 2176 6472854 SGTC_671 0560-0003 407 µM 0.0745677331869344 0.465603761011227 no 1538 0.470279323904653 2229 3238678 SGTC_2245 6637752 200 µM 0.073543652830196 0.466057799202977 no 1539 0.470686754082952 2267 681890 SGTC_2764 methyldopa 94.69 µM 0.0723016661568466 0.46660850797707 no 1540 0.471180919383729 2265 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1385 3091-4834 14.1 µM 0.0711798954255401 0.467105966833702 no 1541 0.471627290975583 2220 4072814 SGTC_1106 tegaserod maleate 11.7 µM 0.0702556886644379 0.467515852893107 no 1542 0.471995075318742 2198 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2618 avocadyne 43.43 µM 0.0700501850854137 0.467606998507074 no 1543 0.472076857893445 2215 3015189 SGTC_2440 5628896 157.78 µM 0.0699346232270375 0.467658253623699 no 1544 0.472122847616279 2241 5522048 SGTC_2162 5663267 200 µM 0.0697912346050122 0.467721851481844 no 1545 0.472179911969349 2276 6456493 SGTC_409 arachidonic acid 100 µM 0.0696396280583344 0.467789095172435 no 1546 0.472240247429997 2300 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1084 voriconazole 435 nM 0.068569230515791 0.468263886210006 no 1547 0.472666255845915 2280 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2067 5224629 34.075 µM 0.0685539770963556 0.468270652423008 no 1548 0.472672326794233 2193 2835000 SGTC_2332 7982454 138.89 µM 0.0685138226952397 0.468288464422503 no 1549 0.472688308506261 2280 2981748 SGTC_1991 st073000 8.92 µM 0.0682682061579555 0.468397418284289 no 1550 0.472786066436867 2261 4301969 YIL048W NEO1 SGTC_1152 3909-8331 15.9 µM 0.067827214444449 0.468593045209305 no 1551 0.472961589824751 2233 16001939 SGTC_2234 tolnaftate 200 µM 0.0677914336815356 0.468608918132469 no 1552 0.472975831503871 2287 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1917 st066507 28.5 µM 0.0662484039131192 0.469293478149336 no 1553 0.473590030318469 2186 3156428 SGTC_1157 4092-0394 27.6 µM 0.0661816980083709 0.469323074063428 no 1554 0.47361658384928 2270 3659885 SGTC_2621 lithochol-11-enic acid 100 µM 0.0651257654690921 0.46979159012337 no 1555 0.474036933048799 2289 6708711 SGTC_811 0416-0114 265 µM 0.064796987388042 0.469937477151393 no 1556 0.474167820063727 2163 6612453 SGTC_529 4076-0302 30.3 µM 0.0644537416650644 0.47008978813816 no 1557 0.474304469642144 2134 5816522 SGTC_2090 5301565 104.445 µM 0.0643852948328848 0.470120161085972 no 1558 0.474331719377265 2244 2056344 SGTC_2047 4141938 200 µM 0.063570804712427 0.470481600396344 no 1559 0.474655989584842 2209 3807862 SGTC_892 0929-0076 29 µM 0.0635041521690782 0.470511179305634 no 1560 0.4746825264835 2289 5751038 SGTC_540 1187-0821 17.3 µM 0.0630305318624293 0.470721366090098 no 1561 0.474871095870333 2208 847520 SGTC_354 2783-3500 4.88 µM 0.061719452103391 0.471303249296856 no 1562 0.475393124480889 2229 6740761 SGTC_949 1165-0505 146 µM 0.0597472096987397 0.47217868461283 no 1563 0.476178485483051 2235 6244267 SGTC_1531 st059297 52.4 µM 0.0596899204694265 0.472204116079622 no 1564 0.476201299861003 2266 7566702 SGTC_3318 9139014 38.6185 µM 0.0595939302667209 0.472246727687957 no 1565 0.476239526361978 2289 16643984 SGTC_2170 morpholine 200 µM 0.0593143454713473 0.472370841722888 no 1566 0.47635086759925 2257 121171 Reacts with secondary amines. SGTC_438 sphingosine 6.67 µM 0.0593078311412717 0.472373733613859 no 1567 0.476353461873854 2265 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2286 7945697 125 µM 0.0589527044239728 0.47253138636777 no 1568 0.476494889476376 2237 1245733 SGTC_2472 5377652 49.4 µM 0.0589220283500859 0.47254500471616 no 1569 0.476507106222684 2172 1610903 SGTC_3181 9108277 49.47 µM 0.0587176029885649 0.472635758210915 no 1570 0.476588519185463 2281 17097298 SGTC_2884 9058502 51.95 µM 0.0585009661530149 0.472731934471483 no 1571 0.476674796467847 2245 6471554 SGTC_1307 1187-1599 12.2 µM 0.0583289673589853 0.472808294736418 no 1572 0.476743297086505 2240 1538471 SGTC_2806 7952793 58.44 µM 0.0578330221302169 0.473028479243586 no 1573 0.476940817166565 2259 2972490 SGTC_2522 biochanin a 4.94 µM 0.0566007075929512 0.47357562473006 no 1574 0.477431635436351 2284 5280373 A possible chelator. SGTC_714 4296-0578 26.1 µM 0.0554813561509531 0.474072658036901 no 1575 0.477877491353027 2294 1589775 SGTC_1699 st031318 29.054 µM 0.054868664243067 0.474344732973667 no 1576 0.478121548284227 2283 5340658 SGTC_2833 9001315 45.46 µM 0.0540592379077934 0.474704189078934 no 1577 0.478443984084433 2191 2989378 SGTC_980 1473-0395 201 µM 0.0537574642515186 0.474838208268372 no 1578 0.478564199547907 2296 768876 SGTC_3247 9135149 49.47 µM 0.0536483356752606 0.474886673516432 no 1579 0.478607672817248 2320 8934436 YOR116C RPO31 SGTC_1842 st055362 61.2 µM 0.0531690168861948 0.475099548860416 no 1580 0.478798620813559 2223 676032 SGTC_690 glyoxal 20.3 µM 0.0484943693065323 0.477176019561334 no 1581 0.480661125903259 2286 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2414 st077232 92.9 µM 0.0461306515926679 0.478226218541603 no 1582 0.481603057784179 2222 729801 SGTC_2551 apiole 73.87 µM 0.0458770579907036 0.478338899203427 no 1583 0.481704119995429 2323 10659 A possible DNA adduct former. SGTC_2287 7945887 168.79 µM 0.0457842000433531 0.478380159727472 no 1584 0.481741126071627 2297 1245853 SGTC_1017 4239-0030 168 µM 0.0452841315784523 0.478602364249794 no 1585 0.481940417814381 2244 1149593 SGTC_1125 tnp00248 1.32998 µM 0.0450808932238821 0.478692674751645 no 1586 0.482021415467957 2315 24207736 SGTC_3057 9095946 49.47 µM 0.0450615348442034 0.478701276851381 no 1587 0.482029130503893 2328 24540043 SGTC_439 amiodarone 34.4 µM 0.0448156470144697 0.47881054055822 no 1588 0.482127126554806 2261 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_347 4534-1311 26.2 µM 0.0429478494017945 0.479640574035964 no 1589 0.482871552803974 2331 2862016 SGTC_1914 st062367 72.6 µM 0.0428800709017434 0.479670695910582 no 1590 0.482898567626529 2303 978205 SGTC_3257 9139206 32.98 µM 0.0415322017138887 0.480269734921701 no 1591 0.483435810868961 2322 4910041 SGTC_1002 4049-0206 172 µM 0.041466914638733 0.480298751865686 no 1592 0.483461834225063 2315 4662749 SGTC_810 3825-7150 143 µM 0.0410822275320077 0.480469728774439 no 1593 0.483615171508126 2333 22330411 YGL099W LSG1 SGTC_317 4495-0002 170 µM 0.040341247815346 0.480799072555436 no 1594 0.483910534763556 2221 15991618 SGTC_2490 carminic acid 95.39 µM 0.0403348358472243 0.480801922544984 no 1595 0.483913090688448 2333 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1526 st051518 75 µM 0.0402485174690442 0.480840289405683 no 1596 0.483947498798337 2185 673993 SGTC_3146 9095609 49.47 µM 0.0402291875273897 0.480848881217705 no 1597 0.483955204088746 2316 17173999 SGTC_2049 5262831 67.185 µM 0.0391177541609243 0.481342908230072 no 1598 0.484398253014429 2289 763417 SGTC_2541 muurolladie-3-one 83.07 µM 0.0379158690703485 0.4818771728408 no 1599 0.484877380229242 2317 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3300 9124615 50.48 µM 0.0372006079593918 0.48219513779768 no 1600 0.485162526933909 2317 24824903 SGTC_2124 5246320 200 µM 0.0364603919142634 0.48252420824104 no 1601 0.485457630184645 2307 579342 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0364041412654293 0.482549215518939 no 1602 0.485480056058778 2329 364106 SGTC_1096 rimcazole 32.2 µM 0.0361377072589144 0.482667664670281 no 1603 0.485586277953917 2336 18528119 A dopamine reuptake inhibitor. SGTC_953 1188-0045 9.7 µM 0.0360762133789894 0.482695003357192 no 1604 0.485610794476142 2303 6144426 SGTC_1465 k213-0056 144 µM 0.0359903508589274 0.482733175886315 no 1605 0.485645026435127 2270 24048857 YMR208W ERG12 SGTC_3068 9116768 49.47 µM 0.0359360814632423 0.482757302910509 no 1606 0.485666662795345 2290 41904888 SGTC_2875 9039966 71.43 µM 0.0359278896115984 0.482760944839779 no 1607 0.485669928762282 2301 6463691 SGTC_153 4077-0274 519.67 µM 0.0356895619505016 0.482866901059523 no 1608 0.485764946803978 2355 3121976 SGTC_3130 9127414 49.47 µM 0.0354145050071035 0.482989187965594 no 1609 0.485874609322159 2352 1494646 SGTC_2293 7624732 200 µM 0.0339376642069609 0.483645800148019 no 1610 0.486463429391134 2342 894453 SGTC_269 exalamide 29 µM 0.0326408778855445 0.484222395673634 no 1611 0.486980485673228 2279 3316 A derivative of salicylamide. SGTC_104 0074-0074 590.992 µM 0.0326172999047848 0.484232879558883 no 1612 0.486989886920754 2356 3943124 SGTC_1814 st052110 31.539 µM 0.0318517032918263 0.484573305900026 no 1613 0.487295157133232 2332 674163 SGTC_1909 st060837 51.5 µM 0.0314145241730247 0.484767704828956 no 1614 0.487469479126631 2309 678937 SGTC_1670 st016595 4.04 µM 0.0309555423935816 0.484971802566665 no 1615 0.487652497347952 2353 597879 SGTC_2419 paclitaxel 166.5 µM 0.0302201550310034 0.485298819151298 no 1616 0.487945737240622 2326 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_645 0845-0943 5.41 µM 0.0294982909339426 0.485619831744435 no 1617 0.488233590993444 2331 1885106 SGTC_1335 1486-0900 202 µM 0.0294321596907225 0.48564924074345 no 1618 0.488259962092243 2353 X1335 SGTC_500 h-89 112 µM 0.0274700343745464 0.486521845601512 no 1619 0.48904241996465 2350 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2157 5649910 96.377 µM 0.0267745375012297 0.486831165687368 no 1620 0.489319781032999 2344 2858091 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0266145010566861 0.486902342529701 no 1621 0.489383603593119 2364 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2636 apigenin dimethyl ether 100 µM 0.0256773290720358 0.487319161782154 no 1622 0.489757353336975 2341 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1253 0550-0034 176 µM 0.0248576196625803 0.487683749421305 no 1623 0.490084265694419 2321 5969915 SGTC_2860 9025725 38.96 µM 0.0247713187032148 0.487722134680664 no 1624 0.490118684197575 2355 40546248 SGTC_1128 3448-9350 235 µM 0.0247424634379678 0.487734969057474 no 1625 0.490130192255688 2285 619386 SGTC_503 tyrphostin 8 294 µM 0.0242949518922084 0.487934016906772 no 1626 0.490308669875277 2352 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0239521961834191 0.488086472632423 no 1627 0.490445369836851 2353 107982 A Capsaicinoid. SGTC_1975 st070967 30.8 µM 0.0236087808382411 0.488239223506367 no 1628 0.490582334004218 2367 261391 SGTC_167 3672-0051 66.205 µM 0.023007455658453 0.488506696612478 no 1629 0.490822162884521 2362 3237971 SGTC_2781 5567276 71.43 µM 0.022851772184965 0.488575946417911 no 1630 0.490884255279174 2358 2853274 SGTC_1730 st033808 45.1 µM 0.0225875069110234 0.488693495448491 no 1631 0.490989654663741 2270 1045166 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.022337640342583 0.488804640629335 no 1632 0.491089311857043 2369 1241132 A phosphatase inhibitor. SGTC_3250 9135583 49.47 µM 0.0215387730822516 0.489159997064818 no 1633 0.491407937091162 2374 7699353 SGTC_1024 4507-0395 26 µM 0.0197583016395621 0.48995202650347 no 1634 0.492118090927439 2290 4201836 SGTC_756 0508-1999 28.3 µM 0.019265070388759 0.490171443887476 no 1635 0.49231482427307 2355 6753853 SGTC_1166 k206-0078 225 µM 0.0190412171896044 0.490271027539662 no 1636 0.492404112399769 2376 5404595 SGTC_2399 5884133 200 µM 0.0187711030624517 0.490391191700824 no 1637 0.492511853088004 2366 722445 SGTC_1090 efavirenz 20.7 µM 0.0185579438992596 0.490486019241886 no 1638 0.492596876479643 2310 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_721 1187-1332 279 µM 0.0177752258342075 0.490834229484635 no 1639 0.492909084279047 2364 25730 SGTC_527 4476-4215 268 µM 0.0173193789823663 0.491037026740423 no 1640 0.493090912864684 2249 4418754 SGTC_3135 9127742 49.47 µM 0.0168923147964664 0.491227021260028 no 1641 0.493261261898852 2330 3643468 SGTC_65 0798-0905 34.986 µM 0.0163631780090963 0.491462429121654 no 1642 0.493472327753021 2372 3602145 SGTC_423 5-fluorouracil 457 µM 0.0162932551445217 0.49149353735503 no 1643 0.493500219221732 2379 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1676 st018489 23.4 µM 0.0145536795186858 0.492267479549052 no 1644 0.494194126861906 2342 3696235 SGTC_2714 st079313 56.9 µM 0.0141814507199447 0.492433089091071 no 1645 0.494342609340668 2384 2939799 SGTC_2063 5246145 200 µM 0.0139293894888022 0.492545235226824 no 1646 0.494443157290398 2376 711240 SGTC_1860 st056228 74.6 µM 0.0138997992215317 0.49255840045616 no 1647 0.494454960956356 2326 688679 SGTC_729 4092-0585 94.1 µM 0.0123645395281614 0.493241475230685 no 1648 0.495067388089304 2381 2169061 SGTC_3025 9087895 49.47 µM 0.0118980689796947 0.493449023461222 no 1649 0.495253469218814 2386 17173641 SGTC_1761 st044296 37 µM 0.0110667528984395 0.493818907939677 no 1650 0.495585094480043 2384 1826700 SGTC_1292 0kpi-0043 232 µM 0.0104066981128265 0.494112595485273 no 1651 0.495848403059441 2372 3333905 SGTC_2373 9071805 200 µM 0.0094061580858883 0.49455778599534 no 1652 0.49624754117712 2390 10149009 SGTC_2060 5238662 140 µM 0.00822542888862983 0.4950831603935 no 1653 0.496718565644305 2380 790130 SGTC_3080 9117754 49.47 µM 0.00822471669999399 0.495083477289892 no 1654 0.496718849756853 2398 9550191 SGTC_1786 berberine 21.6 µM 0.00716987612213984 0.495552843837963 no 1655 0.497139657776653 2394 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1277 0873-0036 22 µM 0.00660764674389482 0.495803018475455 no 1656 0.497363949522015 2394 5965735 SGTC_1859 st055998 20 µM 0.00637870161799354 0.495904892434935 no 1657 0.49745528348703 2394 676301 SGTC_2256 7954252 200 µM 0.00618009700046515 0.495993265962249 no 1658 0.497534513703841 2352 2972920 SGTC_2582 agaric acid 100 µM 0.00612007092521977 0.496019975934004 no 1659 0.497558460190305 2391 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1132 3456-3614 2.5 µM 0.00479355352143052 0.496610244458006 no 1660 0.498087656150626 2395 3125502 SGTC_2021 4019055 173 µM 0.00443928348923045 0.496767887459819 no 1661 0.498228987938419 2392 44827708 YER133W GLC7 SGTC_2407 paclitaxel 400 µM 0.00311332528895877 0.497357916330964 no 1662 0.498757964916057 2373 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2215 7188065 200 µM 0.00255016457427194 0.497608515104409 no 1663 0.498982632632055 2397 940217 SGTC_1806 st050005 60.3 µM 0.00235797847031017 0.497694035498665 no 1664 0.499059303563639 2392 5194765 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0021117091170088 0.497803622411656 no 1665 0.499157550575441 2401 688798 SGTC_1338 1486-1223 76 µM 0.00142704647671791 0.498108289932424 no 1666 0.499430691017569 2397 3444526 SGTC_1234 0326-0494 15.5 µM 0.000708357433635321 0.498428100020692 no 1667 0.499717406293719 2405 1547813 SGTC_3295 9122362 53.5725 µM 0 0.498743313626172 no 1668 0.5 2405 4730473 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.16692281138246e-06 0.498744277891447 no 1669 0.499999135522872 2406 688667 SGTC_1849 st056239 19.2 µM -0.000307014242974318 0.498879932856346 no 1670 0.499877519039716 2401 5393181 SGTC_1064 honokiol 6.76 µM -0.000338373903809703 0.498893887697767 no 1671 0.499865008345762 2407 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_895 0964-0006 13.7 µM -0.000922363166555728 0.499153759281708 no 1672 0.499632030387151 2395 6738897 SGTC_589 1227-0070 34.1 µM -0.000944326177886114 0.499163532692627 no 1673 0.499623268417143 2410 2841384 SGTC_2191 5911152 200 µM -0.00142071526970562 0.499375523151329 no 1674 0.499433216801171 2400 2875902 SGTC_2023 5144124 124 µM -0.00214969237489559 0.499699914172089 no 1675 0.49914239748232 2412 2830192 SGTC_2529 gangaleoidin 93.61 µM -0.00242978157895457 0.499824552475759 no 1676 0.499030658349821 2413 4565183 SGTC_2471 5466956 24.79 µM -0.00252350884085208 0.499866260645875 no 1677 0.498993266696913 2424 724419 SGTC_2955 9076254 12.21 µM -0.00274215050472641 0.499963555114799 no 1678 0.498906041595424 2409 16459619 SGTC_840 0245-0196 390 µM -0.00290594954157502 0.499963555114799 no 1679 0.498840695494786 2413 3827528 SGTC_413 propylparaben 100 µM -0.00293498037415907 0.49995063653632 no 1680 0.498829113917623 2411 7175 A pharmaceutical preservative. SGTC_2200 6600604 21.907 µM -0.003050402372736 0.499899274312252 no 1681 0.498783067408529 2416 2904777 SGTC_287 k060-0039 29.6 µM -0.00353567870731442 0.499683328748303 no 1682 0.49858947121258 2418 5861974 SGTC_1556 plumbagin 1.48 µM -0.00356327261861878 0.499671049596713 no 1683 0.498578462904025 2416 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1932 st074806 40.9 µM -0.00497303468665369 0.499043713247964 no 1684 0.498016054379112 2468 17251235 SGTC_1336 1486-0901 104 µM -0.00497540931949925 0.499042656550997 no 1685 0.498015107049389 2438 5006114 SGTC_1325 1431-0015 227 µM -0.00515189371173695 0.498964122104551 no 1686 0.497944700866219 2415 1103340 SGTC_711 k292-0785 179 µM -0.00527611429714109 0.498908844747887 no 1687 0.497895144696255 2414 4146315 SGTC_2376 9072922 81.32 µM -0.00695215148068889 0.498163021527186 no 1688 0.49722651517615 2463 17087968 SGTC_3090 9117696 49.47 µM -0.00783320505963904 0.49777096209904 no 1689 0.496875035268193 2466 7923821 SGTC_2151 5563267 85.4165 µM -0.00868730075995764 0.497390900690163 no 1690 0.496534312016458 2426 5310824 SGTC_3209 9113616 49.47 µM -0.00876972053978061 0.497354225086577 no 1691 0.496501432534071 2424 16649353 SGTC_2009 4012297 12.05 µM -0.00913044867777472 0.497193706577596 no 1692 0.496357528592632 2433 45595307 SGTC_2963 9082507 9 µM -0.00944575339303074 0.497053401168828 no 1693 0.496231745636718 2440 16459611 SGTC_1120 ficusin 1.78878 µM -0.009535652065429 0.497013397805246 no 1694 0.496195882870536 2451 6199 A DNA cross-linker. SGTC_1518 st038567 90.8 µM -0.0100450095861636 0.496786743044863 no 1695 0.49599268836026 2422 77966 SGTC_2889 9059656 51.95 µM -0.0106806698748611 0.496503887331206 no 1696 0.495739110215443 2428 3949838 SGTC_3040 9091894 49.47 µM -0.0107119484451673 0.496489969056959 no 1697 0.495726632585087 2428 25236966 SGTC_3353 9151644 39.2805 µM -0.0107147570384127 0.49648871929509 no 1698 0.495725512182793 2441 4909158 SGTC_1350 1495-0454 146 µM -0.0110804006420113 0.496326016278111 no 1699 0.495579650151913 2438 1069057 SGTC_3077 9117319 49.47 µM -0.011816112282473 0.495998643352411 no 1700 0.495286162912195 2421 17154678 SGTC_69 0096-0274 206.684 µM -0.0119804070804056 0.4959255367157 no 1701 0.495220623410255 2555 6741392 SGTC_1866 st057638 64 µM -0.0135833828587292 0.49521226442781 no 1702 0.494581180903459 2436 688802 SGTC_2128 5255449 168.493 µM -0.0145140983907139 0.494798133046573 no 1703 0.494209915779694 2439 736008 SGTC_1876 myriocin 605 nM -0.0152563089092983 0.494467882892531 no 1704 0.493913849431089 2438 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_464 bw-b 70c 158 µM -0.0164152342864527 0.493952221116888 no 1705 0.49345156309197 2462 5353454 SGTC_2442 5158906 48.48 µM -0.0168450194091035 0.49376099151737 no 1706 0.493280127344247 2452 1893835 SGTC_2846 9008642 19.48 µM -0.0180931136022977 0.493205669848007 no 1707 0.492782285801486 2467 2992898 SGTC_2749 bexarotene 57.39 µM -0.0184049069265847 0.493066943879082 no 1708 0.492657918972626 2453 82146 An retinoic acid receptor inhibitor. SGTC_2069 5228469 200 µM -0.0187524705203785 0.49291230366016 no 1709 0.492519285088664 2456 2835210 SGTC_150 3970-0969 77.2 µM -0.0188191354258242 0.492882642804735 no 1710 0.492492694331706 2504 6615640 SGTC_2675 theaflavin digallate 100 µM -0.0200344807663378 0.492341912845917 no 1711 0.492007933203182 2461 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2305 7443522 69.23 µM -0.0208318555817791 0.491987153403716 no 1712 0.491689893084488 2457 5415886 SGTC_2726 cimetidine 79.27 µM -0.0210190581527377 0.491903866153947 no 1713 0.491615226413156 2443 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2607 solasodine 47.35 µM -0.0212952844781623 0.491780972488742 no 1714 0.491505052714395 2456 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1783 st039459 87.517 µM -0.0215387666175878 0.491672647426347 no 1715 0.491407939669591 2468 729761 SGTC_2325 6158266 200 µM -0.0223106661691996 0.491329233862115 no 1716 0.491100070314116 2476 3623240 SGTC_917 harmaline 728.087 nM -0.0224429152773918 0.491270397650623 no 1717 0.491047323760652 2472 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3321 9137793 26.8275 µM -0.0226352593485026 0.491184826173257 no 1718 0.490970609066827 2450 4904192 SGTC_631 k072-0230 41.5 µM -0.0228244926994413 0.491100639012376 no 1719 0.490895135381544 2469 5773147 SGTC_1780 st038448 24.544 µM -0.0229858440857729 0.491028856444311 no 1720 0.490830782375116 2533 728868 YDL195W SEC31 SGTC_2141 5621638 7.665 µM -0.0239482398053027 0.490600708591268 no 1721 0.490446947750738 2484 2856238 SGTC_1214 0358-0031 63.7 µM -0.0245090900036746 0.490351204123206 no 1722 0.490223266559787 2493 4301366 SGTC_2622 2-methoxyxanthone 59.94 µM -0.0247257143142151 0.490254835842249 no 1723 0.490136872145704 2480 71034 A hepatoprotective. SGTC_678 1218-2179 85.9 µM -0.0254757833251064 0.489921161836675 no 1724 0.489837732162109 2460 6820081 YOR116C RPO31 SGTC_1455 4262-0120 131 µM -0.0258397740153878 0.489759240288127 no 1725 0.489692568676879 2557 1529587 SGTC_3189 9110682 49.47 µM -0.0263561360074193 0.489529539146389 no 1726 0.489486640189776 2475 17122418 SGTC_1415 3966-0071 78.1 µM -0.0264213592318814 0.489500525155007 no 1727 0.489460628946128 2461 2893185 SGTC_770 0389-1121 67.2 µM -0.027306513097762 0.489106777614881 no 1728 0.489107631053054 2525 6753108 SGTC_2835 9006588 71.43 µM -0.0284499449962429 0.488598154701195 no 1729 0.488651644978452 2563 2345538 SGTC_762 1165-0429 115 µM -0.0289353810773744 0.488382227930338 no 1730 0.488458063704282 2426 5967793 SGTC_2329 6138490 200 µM -0.0290950352202349 0.488311212929341 no 1731 0.488394397721794 2594 720019 SGTC_2829 7992743 58.44 µM -0.0302245313173143 0.487808817850237 no 1732 0.487943992152136 2449 16462845 SGTC_3104 9120930 49.47 µM -0.0303103373726937 0.487770652460904 no 1733 0.487909776165265 2506 17014836 SGTC_3332 9141069 11.198 µM -0.0307963384314829 0.487554487793885 no 1734 0.487715980272473 2472 17332883 SGTC_2030 5175110 200 µM -0.031242478952228 0.487356055605727 no 1735 0.487538081565212 2497 2831986 SGTC_615 k087-0205 167 µM -0.0316187512707728 0.487188701484434 no 1736 0.487388044757039 2469 9642773 SGTC_68 0986-0284 82.829 µM -0.0316887185621884 0.487157582476392 no 1737 0.487360145826546 2622 423278 YIL048W NEO1 SGTC_1204 4049-0315 18.3 µM -0.0317121758496714 0.487147149511514 no 1738 0.48735079242367 2615 588402 SGTC_537 1334-0398 209 µM -0.0319799744880241 0.487028042853302 no 1739 0.487244010385951 2452 5846986 SGTC_1434 4073-0095 163 µM -0.032353878008331 0.486861746713397 no 1740 0.487094921615639 2463 24133745 SGTC_1112 tnp00069 1.16933 µM -0.032513991136461 0.486790536004927 no 1741 0.487031079307862 2553 145826 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0328754436642497 0.486629780654212 no 1742 0.486886957662565 2480 65057 A dermal irritant. YDR527W RBA50 SGTC_142 0335-0849 62.6745 µM -0.0331802449491492 0.486494222527577 no 1743 0.48676542584724 2474 3889043 YPR107C YTH1 SGTC_1176 0848-0131 83.3 µM -0.0334819264362831 0.48636005344464 no 1744 0.486645139182738 2490 6769040 SGTC_1208 2323-2347 50.3 µM -0.0343240890434567 0.485985520335885 no 1745 0.486309357952956 2465 5412760 SGTC_2316 5844804 197.44 µM -0.036386293867587 0.485068453427048 no 1746 0.485487171426261 2477 776813 SGTC_52 0329-0193 875 nM -0.0364371648771739 0.485045831958093 no 1747 0.485466890278665 2585 3739292 SGTC_1447 4239-0816 81.9 µM -0.0368468722286672 0.484863643858649 no 1748 0.485303550384654 2475 1341554 SGTC_2312 7706453 155.7 µM -0.03838796802658 0.484178380115386 no 1749 0.484689177018039 2492 976098 SGTC_237 nikkomycin 200 µM -0.0390833023420477 0.483869207896811 no 1750 0.484411986799144 2484 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2026 5148700 152 µM -0.0405262908057259 0.483227631221002 no 1751 0.483836773611431 2484 79838 SGTC_328 k915-0120 63.5 µM -0.0409908254265481 0.483021100561324 no 1752 0.483651604982658 2530 6624543 SGTC_3347 9188721 44.724 µM -0.0423300642575332 0.482425704802484 no 1753 0.483117789473481 2508 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3246 9135460 32.98 µM -0.0436239710582546 0.481850499865532 no 1754 0.482602071871111 2470 41446951 SGTC_3107 9121808 49.47 µM -0.0438285185464029 0.48175957191772 no 1755 0.482520547204096 2486 662681 SGTC_2704 st078022 71.1 µM -0.0442629429345969 0.481566459436076 no 1756 0.482347404981093 2499 54697681 SGTC_1756 st041558 35.5 µM -0.0442811659411886 0.481558358949097 no 1757 0.48234014217438 2491 3955792 SGTC_1509 1326-1131 80 µM -0.0448776510866377 0.481293213723352 no 1758 0.482102415371201 2468 768313 SGTC_2688 kanamycin b 96.69 µM -0.0451282275163263 0.481181831778214 no 1759 0.482002551016275 2503 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0451483434176747 0.481172890265675 no 1760 0.481994534103969 2503 689007 SGTC_375 3970-0961 9.27 µM -0.0456357797545329 0.48095622785601 no 1761 0.481800275374393 2515 2898222 SGTC_173 1273-0061 2.693 µM -0.047287799973001 0.48022195739858 no 1762 0.481141925708603 2549 2847414 YPL266W DIM1 SGTC_1354 1498-1681 81 µM -0.0478937946825356 0.479952628709762 no 1763 0.480900442421676 2541 5754243 SGTC_2842 9000675 19.48 µM -0.0480533778346296 0.479881704985664 no 1764 0.480836851173768 2546 2989072 SGTC_2740 felodipine 17.08 µM -0.0483354509040418 0.479756344485789 no 1765 0.48072445091255 2516 3333 L-type calcium channel blocker SGTC_943 3253-1379 105 µM -0.050743150431293 0.478686383874401 no 1766 0.479765095923449 2541 668464 SGTC_1427 4048-4900 550 nM -0.0511113120963678 0.478522789396521 no 1767 0.479618411013182 2529 24132586 SGTC_2156 5649887 115 µM -0.0511372636694261 0.478511257821391 no 1768 0.479608071354626 2562 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3084 9116877 49.47 µM -0.0518447481143322 0.478196894244077 no 1769 0.479326199816827 2486 27241325 SGTC_594 1487-1584 10.8 µM -0.0521579481597515 0.478057731283 no 1770 0.479201419902293 2505 5013332 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0537107398792848 0.477367825204203 no 1771 0.478582812984321 2505 140250 A respiratory chain inhibitor. SGTC_1239 0337-0584 35.4 µM -0.0537284136092143 0.477359973144282 no 1772 0.478575772352435 2566 914301 YML130C ERO1 SGTC_972 1319-0219 195 µM -0.0559903905441447 0.476355098818161 no 1773 0.47767473119426 2541 23903702 SGTC_2742 clothiapine 36.27 µM -0.05602777057391 0.476338494132711 no 1774 0.477659842091954 2499 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0561217666429099 0.476296740062959 no 1775 0.477622401995088 2689 5282309 SGTC_3329 9141233 27.5565 µM -0.0562749291267442 0.476228704190027 no 1776 0.477561395417822 2575 4909101 YNL103W MET4 SGTC_2129 girgensonine 121.053 µM -0.0563858451618966 0.476179434924878 no 1777 0.477517216469866 2561 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2983 9022671 12.99 µM -0.0565728927902927 0.476096348582615 no 1778 0.477442714185502 2668 6405161 SGTC_1439 4092-1168 46 µM -0.0565874539436914 0.476089880578511 no 1779 0.477436914416641 2515 2886240 SGTC_1010 4112-3296 15.2 µM -0.0566204465180217 0.476075225436788 no 1780 0.477423773352705 2518 704384 SGTC_2853 9015042 58.44 µM -0.0566509579139564 0.476061672451294 no 1781 0.477411620573116 2516 6457456 SGTC_1956 st077085 54 µM -0.0568854716878041 0.475957503715791 no 1782 0.477318213742765 2541 24208685 SGTC_1056 3448-1962 115 µM -0.0576606534455548 0.475613187256226 no 1783 0.477009467762652 2567 715507 SGTC_551 k048-0028 34.9 µM -0.0589573502907132 0.475037267600116 no 1784 0.476493039261891 2545 6836383 SGTC_1396 3511-0007 98.6 µM -0.0591327329253002 0.47495937649601 no 1785 0.476423193572079 2570 X1396 SGTC_545 4218-0007 221 µM -0.0607261120014174 0.474251767662314 no 1786 0.475788667841528 2579 2840508 SGTC_1211 1056-0033 32.3 µM -0.0616775938623657 0.473829259614732 no 1787 0.475409791749096 2541 6741922 SGTC_520 3584-0023 682 µM -0.0620438422143944 0.473666633881439 no 1788 0.475263959096713 2598 1340790 SGTC_3192 9110362 49.47 µM -0.0623451208139178 0.473532860040685 no 1789 0.475143998563026 2508 16649480 SGTC_432 NS 1619 61.3 µM -0.0632621124954348 0.473125715468217 no 1790 0.474778892576466 2664 4552 A K+/calcium channel activator. SGTC_2375 9072683 200 µM -0.0633319044024201 0.473094728985584 no 1791 0.474751105354647 2509 16798029 SGTC_3092 9117248 49.47 µM -0.0635832122050204 0.472983153718738 no 1792 0.474651049705134 2510 17141857 SGTC_2532 xanthone 78.9 µM -0.0637696090995321 0.472900398869608 no 1793 0.474576838706817 2559 7020 An insecticide. SGTC_489 paxilline 115 µM -0.0644809362378239 0.472584600900614 no 1794 0.474293643098427 2564 105008 A toxic potassium channel blocker. SGTC_1079 idarubicin 2.36 µM -0.0655318316867869 0.472118081126532 no 1795 0.473875281388016 2512 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_827 3253-0474 693 µM -0.0659579819879756 0.471928912807837 no 1796 0.473705639043235 2525 5402065 SGTC_325 2810-4341 181 µM -0.0676639313760663 0.471171704912699 no 1797 0.473026581035717 2538 774970 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0677853435633246 0.471117818469004 no 1798 0.472978255533584 2571 165506 SGTC_2354 9060492 162 µM -0.0691966015673458 0.470491498036159 no 1799 0.472416564091002 2571 6471895 SGTC_806 3966-4455 5.86 µM -0.070335402567986 0.469986147958732 no 1800 0.471963352547656 2551 714982 SGTC_962 1254-0300 21.5 µM -0.0709313145104229 0.469721727515234 no 1801 0.471726210379965 2519 7340576 SGTC_2126 5251174 33.877 µM -0.071066941269625 0.46966154852531 no 1802 0.47167223933366 2558 790722 SGTC_332 4112-0506 40.9 µM -0.0716303591150915 0.469411561658941 no 1803 0.471448039522528 2535 2790355 SGTC_3294 9122953 26.2835 µM -0.0730941121047369 0.468762155294562 no 1804 0.470865613493383 2537 16459826 SGTC_2164 5685496 200 µM -0.0733859788402172 0.468632676037077 no 1805 0.470749487387084 2542 759046 SGTC_2757 clomiphene 4.22 µM -0.0737842815326173 0.468455984528904 no 1806 0.470591017224895 2588 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_822 1487-0950 154 µM -0.0741389335369221 0.46829866218009 no 1807 0.470449918003459 2535 1958375 SGTC_1098 clofazimine 15.1 µM -0.0743418348839868 0.468208658099785 no 1808 0.470369194842597 2633 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1711 st032263 62.8 µM -0.0747169146987656 0.468042282442524 no 1809 0.470219974654161 2573 3958979 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0754800808013414 0.467703779058394 no 1810 0.469916372769029 2540 165521 SGTC_1105 epirubicin 18.1 µM -0.0755304724271843 0.467681428602013 no 1811 0.469896326642377 2546 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1621 st003705 32.4 µM -0.0774275865341463 0.466840066590424 no 1812 0.469141697885076 2532 24207032 SGTC_3317 9138495 8.753 µM -0.0778285104899952 0.466662277363094 no 1813 0.468982233568572 2545 17020139 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0791949049726342 0.466056401615621 no 1814 0.468438798554275 2577 147795 SGTC_3149 9097855 49.47 µM -0.0792772429209815 0.466019894477836 no 1815 0.468406053419715 2620 25236625 YMR079W SEC14 SGTC_1572 epiandrosterone 68.9 µM -0.0798285734368476 0.465775452010232 no 1816 0.468186799261165 2572 441302 A steroid. SGTC_858 0438-0351 2.77 µM -0.0809724087010664 0.465268353012649 no 1817 0.467731947550632 2561 2799119 SGTC_900 1112-0045 141 µM -0.0831276525185273 0.464313017938601 no 1818 0.466875019202534 2579 56211 YIL048W NEO1 SGTC_2212 7123476 200 µM -0.0831297984337126 0.464312066840141 no 1819 0.466874166059109 2569 1085715 SGTC_3111 9122088 49.47 µM -0.0832707832353093 0.464249580927724 no 1820 0.466818115595757 2648 16876704 SGTC_2446 5162541 200 µM -0.0833256445889351 0.464225266050436 no 1821 0.466796304881476 2544 1549321 SGTC_2362 9071156 126 µM -0.0841964213057164 0.463839350595547 no 1822 0.466450131735643 2633 653133 SGTC_2900 5328528 85.29 µM -0.0847953952336326 0.463573913873333 no 1823 0.466212027213996 2538 795359 SGTC_3034 9090421 49.47 µM -0.0853075615920457 0.463346958987752 no 1824 0.466008440084099 2541 17173761 SGTC_955 1216-0110 33 µM -0.0856917080510867 0.463176741036922 no 1825 0.465855746949594 2544 3619719 SGTC_2549 cedrol 20.94 µM -0.0864319407784332 0.462848757838637 no 1826 0.465561528429026 2565 6708665 A sedative which affects the nervous system. SGTC_40 0327-0103 19.753 µM -0.0876920108232549 0.462290502707121 no 1827 0.46506073480063 2596 409036 SGTC_1224 0823-0416 294 µM -0.0886821192938709 0.461851902055735 no 1828 0.464667271637355 2653 3598164 SGTC_3015 9080845 49.47 µM -0.0887624362249728 0.461816325093785 no 1829 0.464635355680741 2647 5296973 SGTC_2871 9038510 12.99 µM -0.0889121412405874 0.461750012996736 no 1830 0.464575867227578 2567 4945164 SGTC_3102 9121669 49.47 µM -0.0893124428633064 0.461572703924627 no 1831 0.464416802807224 2588 41905072 SGTC_2025 5147754 141 µM -0.0896857755516859 0.46140734731907 no 1832 0.464268459925319 2630 315777 YLR208W SEC13 SGTC_88 0180-0332 8.668 µM -0.0897367146953613 0.461384785857724 no 1833 0.464248219758794 2542 3101745 SGTC_1262 0737-0114 49.6 µM -0.0900408235110054 0.46125009557918 no 1834 0.464127387045878 2570 765919 SGTC_2868 9035608 32.47 µM -0.0912462069575161 0.460716273204768 no 1835 0.463648480109366 2534 6462614 SGTC_664 1222-0054 14.9 µM -0.0915922656903965 0.460563028873037 no 1836 0.463510998352313 2596 6813991 SGTC_1856 st057054 55.7 µM -0.091759979970571 0.460488762479366 no 1837 0.463444370610924 2714 1266018 SGTC_2519 cryptotanshinone 88.04 µM -0.0922306473772352 0.460280351276075 no 1838 0.463257394363365 2593 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_266 formosanin C 406 nM -0.0926437027086765 0.460097459647869 no 1839 0.463093311641462 2576 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2108 5365811 200 µM -0.0930221037346994 0.459929919576675 no 1840 0.462943000558109 2643 780283 SGTC_1266 0828-0227 32.9 µM -0.0930895898918141 0.459900040289281 no 1841 0.462916193793449 2650 3913820 SGTC_2669 eugenol 100 µM -0.0941351999740626 0.459437128697886 no 1842 0.46250087949211 2557 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0941443717088584 0.459433068437754 no 1843 0.46249723667699 2566 442882 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0953110984512379 0.458916601662657 no 1844 0.46203386374912 2582 16623 A steroid. SGTC_2105 5350118 200 µM -0.0953806421642196 0.458885819414128 no 1845 0.462006245643242 2606 2133313 SGTC_873 0591-4978 488 µM -0.0959467667619137 0.458635243936445 no 1846 0.461781425690319 2724 3305145 SGTC_160 3453-0671 289.699 µM -0.0972709371625725 0.458049210048376 no 1847 0.46125561765782 2600 5322268 SGTC_1729 st035615 45.989 µM -0.0978246360545321 0.457804188251208 no 1848 0.461035772231565 2729 17385451 SGTC_2592 piperlongumine 83.33 µM -0.0990453116487988 0.457264073946707 no 1849 0.460551146728752 2646 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1819 st053448 58.6 µM -0.0991619266811939 0.457212479219243 no 1850 0.460504851963604 2597 2857616 SGTC_1155 4088-0394 48.2 µM -0.0997973920289118 0.45693133895514 no 1851 0.460252589287434 2570 2326248 SGTC_2457 5731572 11.68 µM -0.101891268525535 0.456005127022443 no 1852 0.459421490299725 2679 2865357 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.102270448820043 0.455837424630263 no 1853 0.459271005359672 2785 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2190 6049624 200 µM -0.103230951705624 0.455412652408942 no 1854 0.458889837611552 2562 2265554 SGTC_3198 9112019 49.47 µM -0.103896451410298 0.455118372078794 no 1855 0.458625761616315 2600 45595555 SGTC_863 0466-0191 129 µM -0.104234892398231 0.454968724761299 no 1856 0.458491472323675 2590 765160 YPR165W RHO1 SGTC_2398 5228213 48.84 µM -0.104381351189603 0.454903967548098 no 1857 0.458433360713482 2617 80771 YMR134W ERG29 SGTC_2969 9091408 28.7 µM -0.105591117243971 0.454369111689461 no 1858 0.457953386381133 2633 4286311 SGTC_1151 3909-8316 15.3 µM -0.106078635717181 0.454153595735707 no 1859 0.457759980860078 2693 800431 SGTC_2352 9027995 87.8 µM -0.107983802450454 0.453311513928267 no 1860 0.457004270422206 2649 2997347 SGTC_860 0443-0016 25.1 µM -0.108440194438621 0.453109820141975 no 1861 0.456823259277318 2614 5337942 SGTC_1067 clotrimazole 1.36 µM -0.108501861795088 0.453082568349428 no 1862 0.456798801868065 2614 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1191 1487-1166 10.6 µM -0.108927677617762 0.452894399554587 no 1863 0.456629926847105 2709 3955771 SGTC_909 3448-9333 149 µM -0.110208690753409 0.452328381438509 no 1864 0.456121935018611 2602 3344074 SGTC_2625 euphol 100 µM -0.110719126026519 0.452102871557421 no 1865 0.45591953942693 2675 6708538 A triterpene alcohol. SGTC_1293 1000-1278 195 µM -0.110894323187963 0.45202547315487 no 1866 0.45585007363861 2691 678847 SGTC_2106 5357045 167.29 µM -0.111449379282998 0.451780273157564 no 1867 0.455630002457474 2714 668842 SGTC_367 0335-0881 7.1 µM -0.111708374791976 0.451665866328295 no 1868 0.455527319386596 2713 23828853 SGTC_2439 5492030 7.2 µM -0.112187152905908 0.451454384874396 no 1869 0.455337507678865 2684 5722370 SGTC_2956 9076196 2.52 µM -0.113962362548692 0.450670376349338 no 1870 0.454633814672678 2655 16423868 SGTC_706 4262-0057 46.9 µM -0.114369817302484 0.450490453941112 no 1871 0.454472319636766 2590 883298 SGTC_2877 9040724 71.43 µM -0.116670024235478 0.449474928718788 no 1872 0.453560772604111 2667 6463895 SGTC_752 1896-0090 130 µM -0.11681972928667 0.449408846384162 no 1873 0.453501454543936 2614 772567 SGTC_3140 9094243 49.47 µM -0.117110465973328 0.449280514317026 no 1874 0.453386258080669 2599 19291112 SGTC_183 3914-0051 30.55 µM -0.117928682144537 0.448919379702089 no 1875 0.453062083375545 2678 1596232 SGTC_861 0443-0273 110 µM -0.117967780781774 0.448902123863151 no 1876 0.453046593398272 2700 6149169 SGTC_3253 9135987 49.47 µM -0.118380876937735 0.448719813427361 no 1877 0.452882938609501 2717 4182430 SGTC_3270 9137563 49.47 µM -0.119481625595122 0.44823407643037 no 1878 0.452446898200316 2754 17015724 SGTC_777 1315-0167 517 µM -0.120042447481049 0.447986627441333 no 1879 0.452224761414956 2712 4221767 SGTC_2185 6113692 200 µM -0.120271170507285 0.447885714785089 no 1880 0.452134170456264 2723 874150 SGTC_2960 9079389 5.97 µM -0.121036509360083 0.447548071653382 no 1881 0.45183105873676 2683 16457355 SGTC_2899 9053889 58.44 µM -0.12137797008368 0.447397442301263 no 1882 0.451695832591705 2612 6470052 SGTC_96 0929-0093 37.281 µM -0.121670405219337 0.447268445749266 no 1883 0.451580026139416 2601 6991579 SGTC_3076 9116187 49.47 µM -0.124048743585196 0.446219541278864 no 1884 0.450638340639726 2724 27241210 SGTC_1624 st003710 6.25 µM -0.124329284678934 0.446095840567431 no 1885 0.450527280681028 2734 24207033 SGTC_2707 st078556 66.6 µM -0.125023148389612 0.445789913529084 no 1886 0.450252612178144 2689 17250899 SGTC_1412 3909-8563 178 µM -0.125079760570334 0.445764954433843 no 1887 0.450230203087638 2681 23767530 SGTC_2183 6420625 130.508 µM -0.12555163877851 0.445556921832577 no 1888 0.450043423291144 2625 2897619 SGTC_2520 obtusaquinone 4.71 µM -0.1257081114853 0.445487942457375 no 1889 0.449981490385609 2757 5967872 SGTC_1288 0973-0013 65.5 µM -0.126336100103181 0.445211116789827 no 1890 0.449732940715081 2717 4315430 SGTC_2763 lisinopril 49.32 µM -0.127677828177123 0.444619755033106 no 1891 0.449201968508583 2620 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2665 lovastatin 100 µM -0.127787867824176 0.444571260910527 no 1892 0.449158425708921 2647 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3275 9138069 49.47 µM -0.128841513273778 0.444106964820616 no 1893 0.448741528213047 2711 17617007 SGTC_2002 4023503 131 µM -0.129304228300029 0.443903090471943 no 1894 0.44855846291199 2639 4736863 YCR052W RSC6 SGTC_149 3970-0822 46.1 µM -0.129949317976056 0.443618885807536 no 1895 0.448303262481249 2625 3114250 YBL034C STU1 SGTC_355 1311-2252 105 µM -0.130164450136173 0.443524112303997 no 1896 0.448218159964782 2672 5338538 SGTC_2907 7721985 69.9 µM -0.130296659756426 0.443465870783008 no 1897 0.448165861335469 2679 3267881 SGTC_1171 0368-0077 21.4 µM -0.130517609274647 0.443368539926829 no 1898 0.448078461560711 2632 3239779 SGTC_2110 5483698 200 µM -0.131416759640611 0.442972488940562 no 1899 0.447722815682518 2685 2848765 YHR062C RPP1 SGTC_2091 4-phenylthiadiazole 200 µM -0.131860045138133 0.44277725482372 no 1900 0.447547495984927 2670 270010 SGTC_2644 guaiazulene 100 µM -0.131879282124994 0.442768782683591 no 1901 0.447539887976083 2720 3515 A coloring agent. SGTC_1652 st011932 78 µM -0.131898585254308 0.442760281440042 no 1902 0.447532253828056 2654 1551076 SGTC_2533 agelasine 13.65 µM -0.133659291949211 0.441984964269058 no 1903 0.446835998283079 2729 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2970 9090938 41.86 µM -0.133798646173996 0.441923609879646 no 1904 0.446780898883527 2715 17217104 SGTC_1100 amiodarone 5.07 µM -0.135416190107839 0.441211545630099 no 1905 0.446141412090471 2695 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2986 9022445 71.43 µM -0.137317665202954 0.440374734232795 no 1906 0.445389853944619 2764 6459286 SGTC_1256 0570-0116 285 µM -0.13735917784606 0.440356468081412 no 1907 0.445373448248814 2677 410638 SGTC_3081 9117243 49.47 µM -0.137445065556826 0.440318676674275 no 1908 0.44533950593099 2835 45595589 SGTC_253 dyclonine 31.25 µM -0.137835213876213 0.440147014563208 no 1909 0.445185326658955 2636 3180 An oral anasthetic. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.138028888947587 0.440061803271715 no 1910 0.445108792994299 2747 1273210 SGTC_937 3122-0005 46.7 µM -0.138205860508427 0.439983943457071 no 1911 0.445038861765923 2778 759535 SGTC_2629 bisabolol 100 µM -0.138651452127211 0.439787912747724 no 1912 0.444862791510868 2791 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2335 9018011 154.17 µM -0.138753126711058 0.439743184752261 no 1913 0.444822617525233 2767 6458208 SGTC_1055 3448-0672 86 µM -0.138787679248273 0.439727984808783 no 1914 0.444808965145608 2793 748378 SGTC_1006 4099-6547 255 µM -0.139370811878466 0.439471473419375 no 1915 0.44457856798819 2748 3146833 SGTC_2921 7974240 10.71 µM -0.139421903836644 0.439449000034474 no 1916 0.444558382319032 2785 2979074 YDR527W RBA50 SGTC_1363 1636-0063 10.4 µM -0.140048054376038 0.439173596396806 no 1917 0.444311011293051 2661 6072185 SGTC_581 0958-0271 211 µM -0.140342611707578 0.439044049610834 no 1918 0.44419464909124 2637 4591145 SGTC_2321 7390090 138.78 µM -0.141394119659512 0.438581648078861 no 1919 0.443779299717292 2739 649046 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.141902038587702 0.438358320275419 no 1920 0.443578692026895 2776 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3208 9114115 49.47 µM -0.142271344158417 0.438195951952705 no 1921 0.443432840151652 2739 650895 SGTC_975 1335-0046 28.5 µM -0.143238242554967 0.4377708962252 no 1922 0.443051014008538 2690 16486740 SGTC_1565 sinapyl alcohol 95.1 µM -0.143845988943128 0.437503763107158 no 1923 0.442811043279771 2729 5280507 A phenol propionate derived from cinnamic acid. SGTC_1063 disulfiram 1.84 µM -0.143930066109459 0.437466809478819 no 1924 0.442777846774475 2641 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_453 enantio-paf c16 10 µM -0.144551644605846 0.437193630003775 no 1925 0.442532439066079 2714 13871343 A lipid and platelet activating factor SGTC_3008 9078912 71.4286 µM -0.144803930084284 0.437082760805926 no 1926 0.442432839587404 2684 16648731 SGTC_1247 0448-0043 5.84 µM -0.145525594327445 0.436765646059024 no 1927 0.442147954745529 2765 3089013 YGL099W LSG1 SGTC_1992 st073643 23.3 µM -0.145923700610668 0.436590726995507 no 1928 0.441990810736986 2660 3161292 SGTC_1286 0929-0070 131 µM -0.146166362450715 0.436484112849241 no 1929 0.441895029600714 2775 1420408 SGTC_3274 9138298 49.47 µM -0.146222420333353 0.436459484320231 no 1930 0.441872903457902 2646 17015756 SGTC_2034 5197015 53.07 µM -0.148465690329972 0.435474126882065 no 1931 0.440987630498093 2810 780676 SGTC_1378 2093-0007 380 nM -0.148572225593135 0.435427341129244 no 1932 0.440945595247515 2762 3618014 SGTC_2310 7668677 200 µM -0.150045538265129 0.434780417879234 no 1933 0.440364343786758 2827 2197143 SGTC_1368 1852-0141 284 µM -0.150796872371497 0.4344505784301 no 1934 0.440067976769591 2807 2838987 SGTC_90 0870-0863 4.608 µM -0.151258696500453 0.434247857941823 no 1935 0.439885824878104 2655 1738164 SGTC_826 1683-5028 118 µM -0.151395194054323 0.434187944824734 no 1936 0.439831990178251 2757 722377 SGTC_2765 myclobutanil 7.74 µM -0.151540614620441 0.434124116777009 no 1937 0.439774637462117 2760 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1650 st011916 45.8 µM -0.151611707351683 0.434092913354519 no 1938 0.439746599513537 2710 242528 SGTC_255 tunicamycin 200.472 nM -0.152477467187242 0.43371295435151 no 1939 0.439405180602313 2779 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2186 6124449 200 µM -0.152907073995738 0.433524434045342 no 1940 0.439235778636611 2811 3834182 YLR033W RSC58 SGTC_2210 7115885 190.385 µM -0.153370889895661 0.433320919064426 no 1941 0.439052899881985 2677 2927039 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.154070149320724 0.433014128676552 no 1942 0.43877721230458 2687 77254 SGTC_1750 st081859 2.357 µM -0.154950925299801 0.432627757881887 no 1943 0.438430002925639 2695 5291695 SGTC_2948 9070189 9.45 µM -0.1552286171476 0.432505955885078 no 1944 0.438320544250414 2797 6473636 YDL196W YDL196W SGTC_2557 derrustone 83.84 µM -0.156007544776624 0.432164334670815 no 1945 0.438013537084911 2780 629853 An antioxidant. SGTC_1228 0124-0032 52.5 µM -0.156864213022128 0.431788676629633 no 1946 0.437675932252349 2748 X1228 SGTC_419 nsc-638432 893 µM -0.159501494380432 0.430632589625628 no 1947 0.436636890522605 2757 368090 SGTC_1235 benzylparaben 21.5 µM -0.159821471317752 0.430492363749436 no 1948 0.436510854912059 2782 7180 SGTC_3182 9108849 49.47 µM -0.161472788269327 0.429768834531115 no 1949 0.435860520957651 2768 17133045 SGTC_2434 5670830 169.91 µM -0.162002891490189 0.429536618181177 no 1950 0.435651788435313 2785 1549830 SGTC_567 1080-0542 68.4 µM -0.164292443052159 0.428533941131687 no 1951 0.434750465216747 2693 5950415 SGTC_1453 4237-0541 195 µM -0.164413376982887 0.428480992575124 no 1952 0.434702866781101 2709 739892 SGTC_1983 st071813 46.9 µM -0.167194962087754 0.427263487157826 no 1953 0.433608324148628 2761 11838595 SGTC_3346 9158254 43.5805 µM -0.167211621871943 0.42725619721125 no 1954 0.433601770115013 2798 17639500 SGTC_1483 3453-0561 55.9 µM -0.167832938314414 0.426984340879732 no 1955 0.433357354500276 2800 4546991 SGTC_2751 anetholtrithion 17.25 µM -0.168003190748555 0.426909853160291 no 1956 0.433290384452601 2833 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.168485887015515 0.426698681258749 no 1957 0.433100522744718 2774 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1194 1488-0194 225 µM -0.169165467050342 0.42640141147943 no 1958 0.432833245789828 2673 1391452 SGTC_1851 st056236 18.9 µM -0.169436587520321 0.426282826476944 no 1959 0.432726623423448 2723 5393171 SGTC_2145 5634607 200 µM -0.169611509501053 0.426206321133296 no 1960 0.432657835216874 2692 308662 SGTC_2997 9067075 71.4286 µM -0.171599563763914 0.425337004878532 no 1961 0.431876175216095 2803 27209819 SGTC_1775 st081588 35.1725 µM -0.171996689080492 0.425163397284846 no 1962 0.43172006597087 2723 1426443 YGL099W LSG1 SGTC_602 3130-1533 38.1 µM -0.173104650097336 0.424679117058799 no 1963 0.43128458494196 2839 720941 SGTC_2271 7849410 118.62 µM -0.173926151134544 0.424320119367361 no 1964 0.430961750108005 2681 972430 SGTC_2300 7976697 71.57 µM -0.174307009115676 0.424153704905111 no 1965 0.430812095545466 2743 2236109 SGTC_886 0866-0150 153 µM -0.174822340527325 0.423928554315374 no 1966 0.430609616732311 2903 271463 SGTC_1611 st001856 99.4 µM -0.178771590165732 0.422203939051184 no 1967 0.429058526825237 2751 647478 SGTC_2801 7907800 81.82 µM -0.180433085676074 0.421478816786487 no 1968 0.428406290967695 2811 6620925 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.18057756962722 0.421415772568598 no 1969 0.428349581633811 2730 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2395 5646831 180.19 µM -0.180913897156732 0.421269027008578 no 1970 0.42821758024715 2877 6808628 SGTC_1685 st024049 53.0905 µM -0.181513110418997 0.42100760693419 no 1971 0.427982421724642 2813 1941139 SGTC_1744 st037937 38.9 µM -0.181642155637883 0.420951312649154 no 1972 0.427931781858998 2893 1016152 SGTC_1246 0422-0085 105 µM -0.18210953502017 0.420747438056236 no 1973 0.427748382996762 2833 264295 SGTC_169 k015-0017 16.025 µM -0.184614768176692 0.419654999099259 no 1974 0.426765600864143 2863 1840002 SGTC_935 2996-0153 430 µM -0.18465865811845 0.419635865820847 no 1975 0.42674838723804 2829 23738523 SGTC_2821 7996764 71.43 µM -0.184703750381461 0.419616208603187 no 1976 0.426730702207084 2920 2987135 SGTC_2229 7354935 190 µM -0.185754928741643 0.419158021924237 no 1977 0.426318475470325 2794 318112 SGTC_3313 9133968 57.047 µM -0.186579141669312 0.418798841367879 no 1978 0.425995311041628 2709 1494643 SGTC_1473 k844-0725 134 µM -0.186700510962384 0.418745956023838 no 1979 0.425947727727305 2757 54682906 SGTC_616 4092-0450 108 µM -0.187672695833614 0.41832239015151 no 1980 0.425566617745486 2795 787165 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.187895895120033 0.418225159032343 no 1981 0.4254791303241 2757 688801 SGTC_2800 7887935 81.82 µM -0.187992290667177 0.418183168297111 no 1982 0.425441347296954 2903 2961002 SGTC_3239 9133757 49.47 µM -0.187992464004797 0.418183092790583 no 1983 0.425441279356466 2735 17036923 SGTC_2221 6807166 181.081 µM -0.188994122732038 0.41774681686726 no 1984 0.425048711581374 2768 674925 SGTC_32 0928-0142 34.1 µM -0.189009558186692 0.417740094692106 no 1985 0.425042662734029 2750 2244242 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.189166698817355 0.417671660962934 no 1986 0.424981083454248 2730 3256 An antibiotic and ribosome inhibitor. SGTC_2700 st077718 96.8 µM -0.18931916286485 0.417605266238477 no 1987 0.424921338553948 2802 904970 SGTC_1139 k015-0024 46.9 µM -0.189709616201066 0.417435243150778 no 1988 0.424768342508645 2737 2766652 SGTC_203 k066-0004 30.888 µM -0.191244984082121 0.416766816468687 no 1989 0.424166830882128 2715 6795412 SGTC_2634 4'-methoxyflavone 100 µM -0.191517877321008 0.416648036760695 no 1990 0.424059937844072 2804 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_609 0986-0026 86.3 µM -0.192013542218174 0.416432312770748 no 1991 0.423865798823938 2758 2848610 SGTC_947 3447-0010 211 µM -0.193243118595467 0.415897283558808 no 1992 0.423384285669948 2708 748350 SGTC_2929 9013348 24.6 µM -0.194860030243139 0.415193949362324 no 1993 0.422751262785648 2861 2995952 SGTC_2656 pseudo-anisatin 100 µM -0.195209148267031 0.415042123438432 no 1994 0.422614608775403 2763 6708809 A neurotoxin. SGTC_257 daunorubicin 18.5 µM -0.195654657599055 0.414848396882419 no 1995 0.42244023818949 2871 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_163 TUB2.036 7.546 µM -0.196926576710439 0.414295426024288 no 1996 0.421942497842736 2806 15992207 YJR013W GPI14 SGTC_910 3454-3003 490 µM -0.198576925208857 0.413578185090906 no 1997 0.421296852572294 2812 820824 SGTC_2176 5809774 33.9695 µM -0.199025158577023 0.413383432688184 no 1998 0.421121532280571 2885 2870539 SGTC_595 3909-8003 73.7 µM -0.199391747288646 0.413224169816798 no 1999 0.420978157793141 2858 699517 SGTC_2216 7189485 200 µM -0.201344343012194 0.41237611427969 no 2000 0.42021466587127 2857 731273 SGTC_2640 pentamidine 10.38 µM -0.201404410461054 0.412350032120759 no 2001 0.420191183412071 2866 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1659 st012954 42.1 µM -0.202344034069907 0.411942084356934 no 2002 0.419823888827195 2901 24207262 SGTC_195 4234-0266 16.654 µM -0.202358688026617 0.41193572293534 no 2003 0.419818161214498 2803 2303354 SGTC_1970 st070122 35.8 µM -0.203068964249707 0.411627413066888 no 2004 0.41954056462581 2933 102928 SGTC_2655 perillic acid 100 µM -0.20357958361767 0.411405802021257 no 2005 0.419341024467262 2762 5702197 An apoptosis inducer. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.20631234582275 0.41022025330937 no 2006 0.418273467703833 2785 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_451 chloral hydrate 100 µM -0.206842869738203 0.409990191909195 no 2007 0.41806628742229 2881 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_536 3852-0578 10.6 µM -0.208081461615621 0.409453197958002 no 2008 0.417582680921502 2931 2869208 SGTC_39 0986-0283 58.349 µM -0.208098665985885 0.409445740162981 no 2009 0.417575964374617 2928 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_38 0929-0051 58.268 µM -0.208623301696083 0.409218335463643 no 2010 0.417371159346864 2897 1379719 SGTC_2488 5268135 45.7 µM -0.209016937785253 0.409047732941059 no 2011 0.417217508102021 2898 1270356 YLR208W SEC13 SGTC_2466 5983409 37.09 µM -0.209320389735998 0.40891622812869 no 2012 0.417099067808792 2816 2879657 SGTC_3064 1327-0027 10 µM -0.210024556688253 0.408611107830401 no 2013 0.416824253494137 2775 16000455 YPR107C YTH1 SGTC_1831 st055328 12 µM -0.210646609418372 0.408341614246985 no 2014 0.416581519592851 2935 1103068 SGTC_2066 5222451 176 µM -0.211294333128681 0.408061045220762 no 2015 0.416328802308016 2769 2281147 SGTC_518 1021-0119 62.6 µM -0.211387069928262 0.408020879056026 no 2016 0.416292622745459 2826 1097762 SGTC_2664 lyso-paf C-16 73.48 µM -0.212389268286665 0.407586868630659 no 2017 0.415901678735282 2786 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1832 st054113 55 µM -0.213288946213815 0.407197352116552 no 2018 0.415550797420288 2824 1251267 SGTC_979 1426-2828 121 µM -0.214682166304962 0.406594337196042 no 2019 0.415007563815004 2923 747872 SGTC_705 1124-0212 310 µM -0.214731135561233 0.406573146293179 no 2020 0.414988473050737 2869 9554485 SGTC_275 trichlorophene 5.69 µM -0.214934178640902 0.406485284570735 no 2021 0.414909318434955 2876 62616 SGTC_270 tamoxifen 5.46 µM -0.21585921684986 0.406085057487671 no 2022 0.414548743929567 2979 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_870 0573-2213 57.6 µM -0.218579743137827 0.404908564559642 no 2023 0.413488716938013 2760 3916321 SGTC_730 1436-0052 41.2 µM -0.219027890046649 0.404714845331007 no 2024 0.413314161043301 2788 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2387 9077560 195.08 µM -0.220982291564978 0.403870295155377 no 2025 0.412553110713424 2796 5303272 SGTC_2365 9042475 200 µM -0.221011406866189 0.40385771701662 no 2026 0.412541775597467 2900 6464479 SGTC_1477 0139-0234 16 µM -0.221209053097479 0.403772334242537 no 2027 0.412464830255877 2785 620880 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.22123850980625 0.403759609396154 no 2028 0.412453362799169 2996 94937 An inhibitor of serotonin biosynthesis. SGTC_681 1642-0006 26.6 µM -0.221952589434133 0.403451169144356 no 2029 0.412175395457007 2807 4446530 SGTC_887 0885-0007 9.62 µM -0.222049635791247 0.403409255476569 no 2030 0.412137621949695 2929 5719458 SGTC_1391 3442-0225 151 µM -0.224720766638532 0.402256049185363 no 2031 0.411098254162548 2812 5227075 SGTC_1937 st074714 47.2 µM -0.225718933478407 0.401825328682604 no 2032 0.410710015650117 2774 17250970 SGTC_3305 9127027 53.8275 µM -0.227135226251274 0.401214386718887 no 2033 0.41015929659922 2847 41905295 SGTC_2920 7982904 15.77 µM -0.227481291117275 0.401065142406203 no 2034 0.410024757726834 2919 6456808 SGTC_121 0557-0495 61.343 µM -0.228007209288785 0.4008383620064 no 2035 0.409820317965338 2802 3104427 SGTC_2717 st081029 62.2815 µM -0.228577216159362 0.400592607918178 no 2036 0.409598767322061 2905 5292846 SGTC_1058 3448-5425 97.3 µM -0.229009491348987 0.400406262014235 no 2037 0.409430769559956 2761 7279705 SGTC_2430 5571206 200 µM -0.229363695873881 0.400253587836409 no 2038 0.409293125274632 2972 1731771 SGTC_2059 5238311 157 µM -0.230204338413231 0.399891303409816 no 2039 0.408966495409509 2812 703021 SGTC_1345 1488-0192 31.4 µM -0.230690450926641 0.399681847007719 no 2040 0.408777646256756 2940 658348 SGTC_968 1309-0633 340 µM -0.231134668680741 0.399490467479604 no 2041 0.408605091255547 2913 3761976 SGTC_2291 7917025 104.35 µM -0.231198296710555 0.399463056993686 no 2042 0.40858037659557 2810 2964612 SGTC_509 pifithrin 175 µM -0.231872901620815 0.399172472679688 no 2043 0.408318366173102 2854 4817 A p53 inhibitor. SGTC_1753 st043925 64 µM -0.233274331293804 0.398568989218609 no 2044 0.407774194737936 2928 670181 SGTC_2594 a-mangostin 100 µM -0.233726345215274 0.39837439468712 no 2045 0.40759871681604 2984 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_842 0271-0008 11.1 µM -0.234238199287417 0.398154069144434 no 2046 0.407400030521073 2930 1221709 SGTC_57 miconazole 162.5 nM -0.234859938574889 0.397886487627728 no 2047 0.407158722148066 2774 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2093 5331342 194.4 µM -0.235133450719792 0.397768789834715 no 2048 0.407052578243149 2960 33839 SGTC_2182 6325192 200 µM -0.235991643583473 0.397399552579589 no 2049 0.406719577261432 2813 736248 SGTC_3265 9137266 49.47 µM -0.237142048236358 0.396904735525889 no 2050 0.406273296390177 2861 17224265 SGTC_1195 1502-0147 41.1 µM -0.237247503464333 0.396859384955253 no 2051 0.406232392823299 2822 817940 SGTC_687 k029-0044 34.9 µM -0.237334836815914 0.396821828676098 no 2052 0.406198519074564 2964 5829338 SGTC_46 0329-0187a 2.197 µM -0.238028220372881 0.396523684409311 no 2053 0.405929603222592 2917 46494817 SGTC_3052 9092717 49.47 µM -0.239067018178339 0.396077130576928 no 2054 0.40552680799678 3003 25237534 SGTC_834 0312-0008 75.7 µM -0.239162353494612 0.396036155071843 no 2055 0.405489846606127 2818 6385573 YIL048W NEO1 SGTC_1728 st035614 33.7865 µM -0.239366991980969 0.395948204501172 no 2056 0.405410511350561 2936 15945546 SGTC_3185 9108267 49.47 µM -0.239489551392044 0.39589553282924 no 2057 0.4053629987753 2912 4910486 SGTC_1801 st050089 28.441 µM -0.239606739339525 0.395845171398816 no 2058 0.405317569858149 2829 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2918 7977171 22.06 µM -0.240864507508833 0.395304756130632 no 2059 0.404830065630524 2785 2236483 SGTC_1471 k673-0312 37 µM -0.240870698238907 0.395302096705731 no 2060 0.404827666501201 2880 24099884 SGTC_913 3487-1245 167 µM -0.243515994038081 0.394166173537418 no 2061 0.403802848254815 2804 4016153 SGTC_605 1315-0399 119 µM -0.245259856517263 0.393417828510658 no 2062 0.403127616234019 2971 24020461 SGTC_862 0452-0056 10.2 µM -0.246019316445519 0.393092043755882 no 2063 0.402833639801994 2842 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_26 0302-0163 425.158 µM -0.246199140990544 0.393014915555891 no 2064 0.402764040244119 2847 3100915 SGTC_2280 7785178 200 µM -0.246702540137407 0.392799025938374 no 2065 0.40256922028677 2853 2954328 SGTC_350 k064-0020 19.8 µM -0.246713753284716 0.392794217401797 no 2066 0.402564880974082 3026 2790705 SGTC_3082 9117008 49.47 µM -0.247673346451719 0.392382775524698 no 2067 0.402193577946374 2875 41448529 SGTC_988 1497-1057 103 µM -0.248570728136499 0.39199811668714 no 2068 0.401846426737061 2853 3533044 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.248663319225016 0.391958433911212 no 2069 0.401810612369016 2944 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2004 4023728 41.89 µM -0.248958813503019 0.391831798213618 no 2070 0.401696320267777 2994 360084 YDR527W RBA50 SGTC_1607 st000305 50.6 µM -0.249067673007729 0.391785148761984 no 2071 0.401654217403567 2986 5457690 SGTC_3352 9151559 45.5865 µM -0.250374610978642 0.391225209624969 no 2072 0.401148830981413 2935 17159339 SGTC_290 2043-6722 48.1 µM -0.250511068032945 0.391166759498932 no 2073 0.40109607323554 2933 773758 YLR208W SEC13 SGTC_2822 7994718 71.43 µM -0.251049069519158 0.390936335463821 no 2074 0.400888085844746 2776 1018011 SGTC_699 0375-0592 111 µM -0.251842442017314 0.39059660685043 no 2075 0.400581425182245 2938 762578 SGTC_2961 9083290 32.55 µM -0.252615479261048 0.390265666273276 no 2076 0.40028268359369 2917 17741490 SGTC_1416 3966-0321 25.3 µM -0.253450932561908 0.389908094507146 no 2077 0.399959886804127 2917 582530 YLR208W SEC13 SGTC_1334 1486-0610 236 µM -0.254256921854103 0.389563221527208 no 2078 0.399648538887277 2946 3742339 SGTC_2951 9072950 58.06 µM -0.254812747592416 0.389325441116979 no 2079 0.399433864524436 2853 16488155 SGTC_3093 9117344 49.47 µM -0.255295483605973 0.389118961864832 no 2080 0.399247443981469 3003 24824913 SGTC_2146 5545642 200 µM -0.256022914724753 0.388807879049051 no 2081 0.39896657172979 2875 825326 SGTC_3152 9099253 49.47 µM -0.257243458678144 0.388286078865678 no 2082 0.398495418667449 2952 25236131 SGTC_1631 benzylvanillin 81.9 µM -0.259633094035306 0.387265059659431 no 2083 0.397573403073608 3005 75506 SGTC_539 4859-0462 2.54 µM -0.259746988684549 0.387216415310275 no 2084 0.39752947226348 3028 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1946 st076057 65.1 µM -0.259958783937405 0.387125962370342 no 2085 0.397447783233296 2842 953009 SGTC_2994 9053520 71.4286 µM -0.261419920735399 0.386502111279768 no 2086 0.396884348245225 3008 4647384 SGTC_2276 7947513 42.08 µM -0.262737476634147 0.385939815260647 no 2087 0.396376464545059 2952 2105100 SGTC_47 0149-0135 24.25 µM -0.263704959431591 0.385527073111377 no 2088 0.396003636849762 2854 5239155 SGTC_1395 3486-0190 4.35 µM -0.264118652440379 0.385350625221646 no 2089 0.395844245752443 3027 6748079 SGTC_3297 9117502 71.43 µM -0.264484304650909 0.385194687395497 no 2090 0.395703378712973 2916 7453720 SGTC_25 0118-0223 35.662 µM -0.264636260836851 0.385129888877289 no 2091 0.395644841795494 3029 5333628 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.264682065377091 0.385110357123914 no 2092 0.395627197324988 2862 66535 A nucleotide analog. SGTC_3097 9117246 49.47 µM -0.265817907842361 0.384626109952022 no 2093 0.395189725390565 2871 16423892 SGTC_3075 9116269 49.47 µM -0.265952203842824 0.384568867011654 no 2094 0.39513800974504 3079 17015205 YNL244C SUI1 SGTC_1683 st010134 710 nM -0.266731350403665 0.384236809718064 no 2095 0.394838006995404 2862 3818134 SGTC_280 3448-3607 3.04 µM -0.267572407980483 0.383878462479332 no 2096 0.394514235988822 2979 626179 SGTC_1481 3346-2004 36 µM -0.268614568945119 0.3834345693734 no 2097 0.394113149914876 2900 2770522 SGTC_1321 1326-2144 215 µM -0.269011754034426 0.383265434463344 no 2098 0.393960318783591 3005 3513030 SGTC_3045 9092950 49.47 µM -0.269244029954417 0.383166533789762 no 2099 0.393870949903077 2995 44120432 SGTC_1328 1441-0025 69.2 µM -0.271456053422798 0.382225059587465 no 2100 0.393020147695985 2861 4562601 SGTC_1014 4130-3005 69.3 µM -0.272189564762108 0.381913018250752 no 2101 0.392738132577005 2865 743608 SGTC_2262 9014885 67.46 µM -0.273379885968691 0.381406809809441 no 2102 0.392280606386474 2886 6457424 SGTC_3344 9148862 3.898 µM -0.275499773814066 0.380505786847963 no 2103 0.391466149782989 3058 4905352 SGTC_490 phenamil 164 µM -0.275944498056199 0.380316846278337 no 2104 0.391295347863325 2980 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2077 5212015 200 µM -0.276013646492155 0.380287471210633 no 2105 0.391268792421757 2827 780900 SGTC_1897 st060201 15 µM -0.276514915360353 0.380074546961478 no 2106 0.391076302634162 2918 611878 SGTC_3222 9128301 49.47 µM -0.276907187966186 0.379907946458607 no 2107 0.390925686569768 2920 4911358 SGTC_1061 3448-9325 110 µM -0.278067524342965 0.379415275277233 no 2108 0.390480262399113 2904 723482 SGTC_2258 7960471 200 µM -0.278585956682892 0.379195215539185 no 2109 0.390281295575278 2965 2974708 SGTC_2650 prasterone 100 µM -0.279402500768446 0.378848695266023 no 2110 0.389967976069342 2904 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_475 α-linolenic acid 10 µM -0.279583046464827 0.378772089457595 no 2111 0.389898707776166 3125 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1470 k295-0292 231 µM -0.281140859241316 0.378111305291781 no 2112 0.389301181648358 3005 5045612 SGTC_1057 3448-5381 134 µM -0.283993943431152 0.376902025549415 no 2113 0.388207511041998 3044 5497911 SGTC_894 0960-0238 55.9 µM -0.285114368225042 0.376427462785526 no 2114 0.387778261231818 2952 6741907 YDL195W SEC31 SGTC_1394 3474-0001 65.7 µM -0.285439958157962 0.376289592164147 no 2115 0.387653549036157 2943 5017666 YIL048W NEO1 SGTC_2361 9034121 116 µM -0.285459000668656 0.376281529126872 no 2116 0.387646255455137 2935 6496917 SGTC_114 0364-0001 490.298 µM -0.286080892196952 0.376018235635266 no 2117 0.387408083025272 2975 4003655 SGTC_1488 4013-0813 75.9 µM -0.286664940727975 0.375771016471004 no 2118 0.387184442310878 2922 2910057 SGTC_2496 diffractaic acid 79.83 µM -0.287977528685378 0.375215603464838 no 2119 0.386681969936348 3163 94870 An apoptosis inducer which activates caspases. SGTC_1377 2944-0135 198 µM -0.289643114873046 0.374511193961953 no 2120 0.386044639623942 3005 1894137 SGTC_259 usnic acid 108.925 µM -0.290256409504117 0.374251924793087 no 2121 0.385810042077293 3122 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_608 k048-0125 159 µM -0.290785242517089 0.374028407265122 no 2122 0.385607786324902 3038 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2701 st077767 14.721 µM -0.291105948323242 0.373892877785397 no 2123 0.385485145372019 2941 5721188 SGTC_2773 thioridazine 9.09 µM -0.291466474549168 0.373740538908422 no 2124 0.385347290381936 2904 5452 An antipsychotic. SGTC_3065 9113888 49.47 µM -0.291619340135841 0.373675952135155 no 2125 0.385288843294931 3123 16648368 SGTC_87 0100-0052 35.5 µM -0.294002452056643 0.372669530571455 no 2126 0.384378014833657 3026 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2167 5876490 200 µM -0.2942324947257 0.372572426193334 no 2127 0.384290125914919 3135 686534 SGTC_405 ebelactone b 50 µM -0.294572624063015 0.372428867462382 no 2128 0.384160188751141 2915 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_247 mechlorethamine 29.705 µM -0.294692988595409 0.372378069328081 no 2129 0.384114209872595 2914 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_29 0299-0004 12.984 µM -0.29514691181527 0.372186517489239 no 2130 0.383940827286181 2961 16871 A napthoquinone isolated from Swertia calycina. SGTC_1872 amphotericin b 148 nM -0.295376802301808 0.372089517668248 no 2131 0.383853026124398 3054 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2437 5741531 144.16 µM -0.295381027150782 0.372087735114547 no 2132 0.383851412600361 3108 2262990 SGTC_556 4058-0063 51.5 µM -0.295555400835769 0.372014165537453 no 2133 0.383784818809416 2983 6615692 SGTC_2647 atorvastatin 60.16 µM -0.296983023120348 0.371412016832019 no 2134 0.383239735160214 2989 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_312 4092-0653 6.84 µM -0.297342059998831 0.371260630149568 no 2135 0.383102686810302 3033 1148278 SGTC_747 3448-8087 38.7 µM -0.297430311131679 0.371223422407093 no 2136 0.383069002615601 2977 5168703 SGTC_258 haloperidol 50.781 µM -0.297967613000748 0.370996915438737 no 2137 0.382863941266929 2973 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_523 1934-0222 13.7 µM -0.298578688259659 0.370739362602307 no 2138 0.382630764192422 2942 1361595 SGTC_588 3970-1144 52.9 µM -0.299290946149942 0.37043923692549 no 2139 0.382359031051171 3049 1888707 SGTC_718 1130-0073 349 µM -0.300058486518199 0.370115905010978 no 2140 0.382066271961339 3104 6740020 SGTC_2865 9030313 51.95 µM -0.300577873731769 0.369897161447669 no 2141 0.381868202926022 2906 42562754 SGTC_2372 9071633 200 µM -0.301050386406281 0.369698195982719 no 2142 0.381688036419625 3069 21321366 SGTC_1261 0712-0010 12.7 µM -0.302043799809598 0.369280003643488 no 2143 0.381309336925275 3123 2840123 SGTC_56 0957-0365 83.25 µM -0.302863102544493 0.368935222149755 no 2144 0.380997095698582 3058 6752360 SGTC_478 N-arachidonylglycine 10 µM -0.303259481688089 0.368768454489544 no 2145 0.380846061004283 3029 5283389 SGTC_382 3229-0966 23.2 µM -0.303834188570205 0.368526703310907 no 2146 0.380627109283092 3107 5722370 SGTC_1990 st072050 59.8 µM -0.304556741794429 0.368222834218491 no 2147 0.380351885343918 2921 17233948 SGTC_1495 4469-0029 237 µM -0.304817693230898 0.368113111580332 no 2148 0.380252502586022 2933 793680 SGTC_443 clozapine 122 µM -0.305046134912472 0.368017067197762 no 2149 0.380165507582728 2978 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2696 st077691 74.316 µM -0.305383266655813 0.367875341017966 no 2150 0.380037132381022 3102 757133 SGTC_431 k089-0097 107 µM -0.306006609937376 0.367613342291302 no 2151 0.379799806520604 3059 5499420 SGTC_2682 pyrogallin 40.03 µM -0.306273964319623 0.367500988877337 no 2152 0.379698030392453 2981 822798 An ATP competetive kinase inhibitor. SGTC_2941 9056145 11.23 µM -0.306828950457994 0.367267796869103 no 2153 0.379486785583131 2950 2119517 SGTC_3009 9080819 71.4286 µM -0.306878340443044 0.367247046739777 no 2154 0.379467987976428 3019 17027216 SGTC_457 grayanotoxin iii 135 µM -0.307428116299487 0.367016096546247 no 2155 0.37925876499836 2993 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1163 k060-0048 49.9 µM -0.308618579650773 0.366516170937546 no 2156 0.378805842917821 2952 6809982 SGTC_3215 9129942 49.47 µM -0.309103191913385 0.366312726666177 no 2157 0.378621515605752 3084 17682944 SGTC_2051 5263410 176 µM -0.311296420377961 0.36539246156762 no 2158 0.377787644160752 3030 227584 SGTC_1973 st070275 50.2 µM -0.311469784109355 0.365319752176725 no 2159 0.377721755021038 2979 17118334 SGTC_2206 7254556 146.969 µM -0.31172388449408 0.365213190281818 no 2160 0.377625187296084 2999 4398905 SGTC_178 4092-0806 87.505 µM -0.315220978878272 0.363747676726005 no 2161 0.376296939041404 3043 2169044 SGTC_2257 7960413 200 µM -0.315603933973563 0.363587313822459 no 2162 0.376151575659418 2947 2974689 YIL048W NEO1 SGTC_1927 st060202 13.8 µM -0.315767469423744 0.36351884043732 no 2163 0.376089505675447 2946 688887 SGTC_2648 atorvastatin 78.68 µM -0.316133391992011 0.363365642009425 no 2164 0.375950631144096 3065 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.316535132806943 0.363197472953682 no 2165 0.375798181411457 2978 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1684 st024538 14.6195 µM -0.317432740899637 0.362821828739524 no 2166 0.375457633583665 2970 6732859 SGTC_779 1360-0071 233 µM -0.317445426194748 0.362816520955832 no 2167 0.375452821543532 3162 7566 SGTC_2784 7567673 72.73 µM -0.317527327286932 0.362782252519093 no 2168 0.375421753647838 2953 3471247 SGTC_365 0121-0052 13.6 µM -0.319777039342363 0.361841375525386 no 2169 0.374568677186172 3097 3101739 SGTC_1688 st021091 57.6 µM -0.320971679437683 0.361342090698058 no 2170 0.374115926418701 3092 3656366 SGTC_455 paf C-16 10 µM -0.322822743129758 0.36056892838782 no 2171 0.373414743948491 2965 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2463 5473429 200 µM -0.324199688161295 0.359994167813225 no 2172 0.372893429075643 3034 5399405 SGTC_1776 st049249 45.9 µM -0.325310041957598 0.359530917373249 no 2173 0.372473215734009 3019 1822314 SGTC_323 4013-0906 34.3 µM -0.325570729720313 0.359422185780554 no 2174 0.372374580442697 3065 2910086 SGTC_1615 st002656 86.5 µM -0.325783391907329 0.359333493850177 no 2175 0.372294122578488 2972 1584458 SGTC_138 0850-0259 40.9225 µM -0.326211157299392 0.359155114907953 no 2176 0.372132300209752 3056 6813004 SGTC_2584 androsterone 48.74 µM -0.326422818410696 0.359066863192613 no 2177 0.372052237792916 3101 2754130 A steroid. SGTC_3053 9095903 49.47 µM -0.326824701462296 0.358899319484332 no 2178 0.371900237712426 3052 17174018 SGTC_2721 ifenprodil 61.44 µM -0.327472381238283 0.358629361068657 no 2179 0.371655314493697 3113 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_407 eburnamonine 100 µM -0.327567312357501 0.358589798904959 no 2180 0.371619420197263 2945 3195 SGTC_444 curcumin 90.4 µM -0.328509343037395 0.358197293695995 no 2181 0.371263290599055 3105 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1739 st037196 92.5 µM -0.328946358157806 0.358015258419869 no 2182 0.371098116798736 3177 612214 SGTC_2088 5278280 127.392 µM -0.330145089145536 0.357516102080029 no 2183 0.370645167594427 3079 791502 SGTC_2092 5303694 80.6725 µM -0.33123729496599 0.357061515332361 no 2184 0.370232625722185 3004 1963699 SGTC_2275 7947463 200 µM -0.331257987722651 0.357052904760565 no 2185 0.370224811208871 3127 1225414 SGTC_683 panaxydol 45 µM -0.332286169869085 0.356625154249868 no 2186 0.36983659101562 2996 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_741 4582-0002 126 µM -0.332308448286311 0.356615887842271 no 2187 0.369828180615174 2969 2912688 SGTC_2697 mebhydrolin 72.4 µM -0.333146795628291 0.35626725011206 no 2188 0.369511738571207 3152 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2952 9073731 13.78 µM -0.334131873440223 0.355857746085695 no 2189 0.369140024674674 3021 16457353 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.334732970125174 0.355607947459856 no 2190 0.368913264099461 3232 6710655 SGTC_2973 9094665 17.96 µM -0.337626733502291 0.35440625140464 no 2191 0.367822246789859 3202 25237061 YIL048W NEO1 SGTC_997 3996-0078 137 µM -0.337668132016726 0.354389070279395 no 2192 0.367806646280432 3062 735687 SGTC_2391 6285546 200 µM -0.338269958426529 0.354139335017933 no 2193 0.36757988020905 2965 846083 SGTC_739 1486-1183 203 µM -0.339797811481466 0.353505615577557 no 2194 0.367004398071232 3139 4346692 SGTC_1854 st056233 32.9 µM -0.340361139495164 0.353272061968731 no 2195 0.366792289874518 3109 5393174 SGTC_2719 novobiocin 32.65 µM -0.340814372123978 0.353084193581653 no 2196 0.366621665078134 3124 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_6 0844-0013 19.835 µM -0.341113319608942 0.352960297159021 no 2197 0.366509137175556 3086 1584900 SGTC_801 0866-0028 10.1 µM -0.341132469724194 0.35295236107624 no 2198 0.366501929202472 2966 6849771 SGTC_3035 9091303 49.47 µM -0.341207700877958 0.352921184825016 no 2199 0.366473613163932 3026 25237002 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.341512522046876 0.352794875172237 no 2200 0.366358889837359 2982 16486 A toxic proline analog. SGTC_276 colchicine 750 µM -0.341878179105641 0.352643378175665 no 2201 0.366221285905202 3147 2833 A microtubule depolymerizer. SGTC_2133 5320837 200 µM -0.341996006337118 0.352594565630144 no 2202 0.366176948867639 3156 2841355 SGTC_264 promethazine 12.5 mM -0.342570926810448 0.352356426891273 no 2203 0.365960638515292 3084 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1035 k081-0041 55.2 µM -0.345521710365607 0.351135090565403 no 2204 0.364851095803284 3163 731709 SGTC_618 k072-0232 33.2 µM -0.345747966072751 0.351041506036694 no 2205 0.364766066533176 3089 5872756 YGL099W LSG1 SGTC_3202 9113761 49.47 µM -0.347962974369607 0.350125805920245 no 2206 0.363933995048192 3164 4798415 SGTC_1408 3909-7976 48.8 µM -0.348377511537519 0.349954529885692 no 2207 0.363778344589895 3053 24152374 SGTC_1270 0831-1170 17.3 µM -0.349790524688355 0.349370938934547 no 2208 0.363247955293953 3020 6764716 SGTC_2344 7990960 76.95 µM -0.34983535558736 0.349352429067222 no 2209 0.363231131830742 3039 140813 SGTC_1036 k216-0215 33.5 µM -0.351895955830891 0.348502031821402 no 2210 0.362458146124473 3002 622330 SGTC_352 k048-0007 5.11 µM -0.352019952773129 0.348450883261545 no 2211 0.362411649432422 3119 6811911 SGTC_2405 ticlatone 3.52 µM -0.353488137890105 0.347845468712053 no 2212 0.361861260057244 2850 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1016 4226-1401 38 µM -0.354274228219619 0.347521479125204 no 2213 0.361566689897753 3081 2901613 SGTC_1638 st008370 60.6 µM -0.35566269964922 0.346949488446172 no 2214 0.361046591083214 3044 24207134 SGTC_3337 9144342 33.5465 µM -0.356731078576089 0.346509599368673 no 2215 0.36064656847326 3127 17682949 SGTC_945 3381-0768 11.3 µM -0.360693240775014 0.344880048761553 no 2216 0.359164389067321 3183 1126236 YIL048W NEO1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.360709496953784 0.344873368849192 no 2217 0.359158312245718 3180 756377 SGTC_2580 diallyl disulphide 81.36 µM -0.36191222316967 0.344379284513778 no 2218 0.358708812741388 3017 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2005 4024620 188 µM -0.362308165177422 0.344216688122326 no 2219 0.358560878579864 3025 236743 SGTC_2980 9014342 25.29 µM -0.36436155495951 0.343373911500442 no 2220 0.357794019954521 3194 2996599 SGTC_342 k048-0088 23.3 µM -0.365666131094787 0.342838875838576 no 2221 0.357307110919626 3022 6820570 SGTC_1493 4348-0038 111 µM -0.367384050778898 0.342134799497587 no 2222 0.356666283367673 3137 800424 SGTC_1360 1598-0022 39.8 µM -0.368511162320395 0.341673159195877 no 2223 0.356246061771685 3160 761525 SGTC_2158 5657123 3.6195 µM -0.368789171109559 0.341559329225343 no 2224 0.356142438418611 3063 2858827 SGTC_1700 st030840 7.9285 µM -0.370498058018248 0.340859946789501 no 2225 0.355505711625213 3159 5499307 SGTC_508 roscovitine 141 µM -0.371783867429121 0.340334074088752 no 2226 0.355026888011475 3038 160355 A CDKinase inhibitor. SGTC_1944 st076371 56.9 µM -0.372831533551173 0.339905827053161 no 2227 0.354636915932662 3026 24208455 SGTC_152 4469-0003 551.229 µM -0.37478372165448 0.33910839625031 no 2228 0.35391066079259 3137 697280 SGTC_1706 st031321 9.9705 µM -0.37605305469443 0.338590284578465 no 2229 0.353438726954537 3168 6103185 SGTC_623 k072-0108 16.9 µM -0.37735372818722 0.338059697190899 no 2230 0.352955374472281 3131 5382803 SGTC_1843 st055809 45.5 µM -0.377880947573336 0.337844718623741 no 2231 0.352759518259003 3205 16413835 SGTC_1317 1273-0028 910 nM -0.378839166573953 0.337454131434184 no 2232 0.35240365034947 3073 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3139 9095020 49.47 µM -0.379702713305668 0.337102284311444 no 2233 0.352083052916776 2977 25236292 SGTC_2537 larixol 68.93 µM -0.380567697587286 0.336749994267222 no 2234 0.351762027150673 3142 6708759 SGTC_2353 9059630 146.67 µM -0.381507800976196 0.336367272168339 no 2235 0.351413241898493 3172 4779114 SGTC_1407 3909-7909 12.3 µM -0.382860964912815 0.335816688114783 no 2236 0.350911427796442 3092 4411780 SGTC_911 3456-4043 236 µM -0.382939115290613 0.335784900532985 no 2237 0.350882454049638 3154 914281 SGTC_2298 7976326 193.81 µM -0.383761510668657 0.335450463371782 no 2238 0.350577608886419 3055 2235818 SGTC_1833 st055984 71 µM -0.387366441190971 0.333986015056512 no 2239 0.349242472145842 3106 676288 SGTC_2389 9091542 195.52 µM -0.387710948326383 0.333846196067802 no 2240 0.34911497638124 3127 3626624 YOL127W RPL25 SGTC_1150 3909-7983 10.9 µM -0.388166754856689 0.333661241420335 no 2241 0.348946316925531 3111 23965914 SGTC_3309 9129340 25.759 µM -0.388183681885108 0.333654373642615 no 2242 0.34894005408948 3125 17158987 SGTC_1031 k035-0009 16 µM -0.388893562247071 0.333366405162068 no 2243 0.348677442322572 3248 5180959 SGTC_665 3914-0008 307 µM -0.38902828156565 0.333311766303898 no 2244 0.348627612698942 3077 1069549 SGTC_2746 daunorubicin 9.88 µM -0.390870147278968 0.332565105816862 no 2245 0.347946610548762 3127 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2993 9054257 71.4286 µM -0.391974764934551 0.332117631140332 no 2246 0.347538429756233 3070 6470217 YGL055W OLE1 SGTC_922 1866-0035 480 µM -0.394122060883061 0.331248458205726 no 2247 0.346745462120707 3090 3156169 SGTC_1161 k007-0610 110 µM -0.395505163079387 0.330689092852961 no 2248 0.346235055997411 3230 5843850 SGTC_18 0111-0177 500 nM -0.395617476754966 0.330643686623205 no 2249 0.346193621130638 3122 721752 SGTC_58 0957-0393 9 µM -0.39701021142458 0.33008083839456 no 2250 0.345679965249795 3229 6997992 SGTC_2417 cerulenin 830 nM -0.397019869386256 0.330076936646642 no 2251 0.345676404277532 3220 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1073 triclabendazole 3.09 µM -0.39855599834198 0.32945658695021 no 2252 0.345110194506578 3190 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2249 haloperidol 116.36 µM -0.399748610721441 0.32897528619437 no 2253 0.344670842208424 3105 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_249 wiskostatin 11.211 µM -0.400363690233714 0.328727170219908 no 2254 0.344444331881021 3214 2775510 A n-wasp and actin depolymerizer. SGTC_1590 st077108 57.8 µM -0.400982550924238 0.328477605132202 no 2255 0.344216485377905 3206 5489485 SGTC_381 3461-2219 42.7 µM -0.401971499652577 0.328078955192525 no 2256 0.343852500610107 3211 2883159 SGTC_2826 7992541 19.48 µM -0.402010788969227 0.328063121522115 no 2257 0.343838043076037 3115 2985066 SGTC_634 1611-4317 11.2 µM -0.402042924338787 0.328050171135888 no 2258 0.343826218194113 3241 2843522 SGTC_2255 7941087 197.44 µM -0.402380425578187 0.327914172386129 no 2259 0.343702036777988 3260 935561 SGTC_1273 0849-0096 14.1 µM -0.403664155336976 0.327397092065284 no 2260 0.343229850804389 3156 5286025 SGTC_75 0159-0059 199.013 µM -0.403694021199803 0.327385066171896 no 2261 0.343218868347402 3381 5377270 SGTC_999 SEC7.066 22.7 µM -0.4045326645209 0.327047448281319 no 2262 0.342910531410024 3097 740511 YDR170C SEC7 SGTC_2935 9038016 29.96 µM -0.406030199910601 0.326444928134474 no 2263 0.342360205409265 3272 6463195 SGTC_73 0327-0325 16.231 µM -0.406569421661132 0.326228087748633 no 2264 0.342162129846927 3210 53298 SGTC_1661 st013063 9.66 µM -0.407270076164656 0.325946417211334 no 2265 0.341904819093455 3132 721395 SGTC_3252 9135871 49.47 µM -0.407354858213682 0.325912340660588 no 2266 0.341873688421242 3253 17682838 SGTC_3283 9109332 35.8195 µM -0.407400974660674 0.325893805632253 no 2267 0.341856755618396 3127 17027281 SGTC_2810 7959871 45.46 µM -0.407586429689013 0.325819272270117 no 2268 0.341788664395129 3195 2974535 SGTC_957 1187-1561 14.1 µM -0.407953554182758 0.325671747473992 no 2269 0.34165388702736 3221 1538454 SGTC_1882 5615643 20 µM -0.40890826892419 0.325288234075062 no 2270 0.341303490262545 3200 2253075 SGTC_2341 7987486 176.74 µM -0.410223714020224 0.324760116644139 no 2271 0.340820923335762 3274 1258686 SGTC_127 0180-0333 59.125 µM -0.411190529132444 0.324372189590745 no 2272 0.340466416175332 3192 771601 SGTC_2367 9070478 135.38 µM -0.411827198767955 0.324116834860406 no 2273 0.34023304211494 3104 572802 SGTC_492 tmb-8 126 µM -0.412028887967592 0.324035958834476 no 2274 0.340159124807172 3156 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1436 4092-1007 8.32 µM -0.413017718010793 0.323639564797024 no 2275 0.339796816268722 3139 2881121 SGTC_837 0091-0265 12.5 µM -0.4136722918007 0.323377274641744 no 2276 0.339557060991024 3129 759367 SGTC_3167 9103034 49.47 µM -0.415033519408646 0.322832106774279 no 2277 0.339058682673612 3196 5127859 SGTC_1331 1472-0049 76.2 µM -0.415070704036935 0.322817219768228 no 2278 0.339045072428899 3085 24051409 SGTC_888 0916-0002 6.97 µM -0.415706583097543 0.322562687149853 no 2279 0.338812361745647 3278 2802138 YIL048W NEO1 SGTC_2663 amphotericin b 100 µM -0.416205666940272 0.322362969779512 no 2280 0.338629756661221 3201 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1805 st050013 60.3 µM -0.416594860786248 0.322207262436454 no 2281 0.338487384510381 3155 4037144 SGTC_2487 5918373 44.05 µM -0.417626993302402 0.321794481510155 no 2282 0.3381099288853 3296 2876279 SGTC_923 1900-2434 73.3 µM -0.418512562957041 0.321440490693168 no 2283 0.337786201620617 3099 5910570 SGTC_1921 5740136 50 µM -0.420308257769153 0.320723191304295 no 2284 0.337130139081844 3291 1774243 SGTC_1530 rhein 70.4 µM -0.420834374256346 0.320513157978097 no 2285 0.336938014507155 3167 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2959 9079155 11 µM -0.421060703704776 0.320422821656079 no 2286 0.336855377738385 3272 16189457 SGTC_582 0987-0078 156 µM -0.421343452314263 0.320309981340875 no 2287 0.336752152429309 3286 1625765 SGTC_2408 sulbentine 18.36 µM -0.421345551665696 0.320309143586399 no 2288 0.336751386048178 3114 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_99 0109-0120 622.8 µM -0.422405125741473 0.319886433323818 no 2289 0.33636466859985 3348 759414 SGTC_823 0417-1665 178 µM -0.422903711410633 0.319687606625696 no 2290 0.336182757426752 3208 3429856 SGTC_2915 7971052 15.16 µM -0.425227152767212 0.318761745391702 no 2291 0.335335546030458 3199 5741558 SGTC_1279 0874-0590 65.2 µM -0.425251402551621 0.318752088116634 no 2292 0.335326708080256 3195 3523074 SGTC_2596 sinensetin 100 µM -0.425706097935917 0.318571032256421 no 2293 0.335161009047687 3156 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2120 5538279 151.968 µM -0.426203944707346 0.31837284355038 no 2294 0.334979621668633 3175 2058197 SGTC_2241 6772625 37.8075 µM -0.42679430764711 0.318137892273964 no 2295 0.334764576476391 3230 2285411 SGTC_2425 5628681 7.85 µM -0.426934634747261 0.318082055977688 no 2296 0.334713468991861 3216 5714958 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.426952612801629 0.318074902790266 no 2297 0.334706921560264 3191 6708561 SGTC_1080 nisoldipine 24.4 µM -0.427612666627367 0.317812324669668 no 2298 0.334466571219842 3089 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2161 5662504 8.5105 µM -0.429305512567537 0.317139307138418 no 2299 0.333850452819479 3165 2859334 SGTC_2418 pentamidine 31.67 µM -0.429350996497843 0.317121232614308 no 2300 0.333833904919982 3249 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3120 9124077 49.47 µM -0.431396769453128 0.316308729612731 no 2301 0.333089949245726 3215 18774327 YGL155W CDC43 SGTC_636 0kpi-0074 126 µM -0.431900350920418 0.3161088619999 no 2302 0.332906919859672 3210 616434 SGTC_2027 5150920 200 µM -0.432438642275346 0.315895277708252 no 2303 0.332711318993559 3202 786715 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.433037377414755 0.31565778259961 no 2304 0.332493807935447 3245 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1289 0976-0073 69.1 µM -0.434273709583565 0.315167618276778 no 2305 0.332044846409039 3266 3391136 SGTC_2947 9072639 7.68 µM -0.434863993949706 0.314933704938921 no 2306 0.331830575571919 3248 16488146 SGTC_294 k038-0071 157 µM -0.435621213195105 0.314633748602555 no 2307 0.331555788580465 3222 24152826 SGTC_8 0354-0001 70 µM -0.437661203578332 0.313826258639283 no 2308 0.330815948595155 3198 4993152 SGTC_330 1488-0319 80.1 µM -0.437946437597173 0.313713425282694 no 2309 0.330712555794502 3228 6846614 SGTC_3212 9128307 49.47 µM -0.438479344717776 0.31350266367003 no 2310 0.330519420038725 3052 27243542 SGTC_1874 staurosporine 7.6 µM -0.438510858419085 0.313490202093353 no 2311 0.330508000281981 3266 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1042 0350-0096 82 µM -0.440728083145812 0.312613971980854 no 2312 0.329704931608276 3167 3122515 SGTC_748 act1.228 77.9 µM -0.442002244123777 0.312110911765606 no 2313 0.3292437910049 3182 4421505 YNR035C ARC35 SGTC_658 3253-0951 102 µM -0.442369359785784 0.311966033257396 no 2314 0.32911097373483 3220 1184878 SGTC_2809 7964133 12.99 µM -0.442501088569473 0.311914054905555 no 2315 0.329063321375518 3198 1253665 SGTC_3158 9100007 49.47 µM -0.443832627434059 0.31138885855434 no 2316 0.328581798581935 3173 19297233 SGTC_1651 st011928 86.1 µM -0.444213592991691 0.311238665565155 no 2317 0.328444082777732 3277 720198 SGTC_633 0437-0093 97.7 µM -0.444517522903876 0.311118865867824 no 2318 0.328334231414141 3199 2831118 SGTC_944 3370-0224 231 µM -0.444754540412324 0.311025454839274 no 2319 0.32824857493417 3204 4580514 SGTC_841 0251-0215 91.2 µM -0.444811670900592 0.311002940949001 no 2320 0.328227929723154 3253 3888614 SGTC_970 1315-0089 19.5 µM -0.444951145453166 0.310947980014619 no 2321 0.328177530089904 3262 6811083 YLR033W RSC58 SGTC_1919 st067113 52.3 µM -0.447526675414355 0.309933833117365 no 2322 0.327247415991626 3301 1268243 SGTC_1771 st048882 4.1505 µM -0.44806529230245 0.309721928409257 no 2323 0.327053037864487 3176 4580403 SGTC_1630 st005209 31.3 µM -0.448250697860262 0.309649000071467 no 2324 0.326986138845613 3322 3367314 SGTC_1425 4048-4433 7.33 µM -0.448759357594305 0.309448959824787 no 2325 0.326802630091571 3296 23734946 SGTC_1908 st060353 56.5 µM -0.449385084809704 0.309202957968894 no 2326 0.326576944455113 3370 4227716 SGTC_1339 1486-1321 22.7 µM -0.450271182682427 0.308854738860889 no 2327 0.326257457585571 3209 3469382 SGTC_2626 ethyl orsellinate 100 µM -0.450585865482794 0.308731115994838 no 2328 0.326144027837635 3155 75653 A natural product. SGTC_1066 ketoconazole 628 nM -0.450716254995241 0.308679898936875 no 2329 0.326097032683287 3316 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_118 0083-0097 135.343 µM -0.451053546386789 0.308547427995737 no 2330 0.325975478503656 3293 5207356 SGTC_743 1275-0778 158 µM -0.451991497269181 0.308179179514727 no 2331 0.325637553926119 3282 2849257 YMR203W TOM40 SGTC_373 0844-0104 25.9 µM -0.454576190853372 0.307165403627344 no 2332 0.324707083430203 3314 5375804 SGTC_1825 st052143 62.6 µM -0.454810657442292 0.307073513187 no 2333 0.324622731177961 3338 674173 SGTC_1547 harmine 94.2 µM -0.455611132051209 0.306759888315425 no 2334 0.324334818342642 3248 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1913 st060213 96.1 µM -0.456836039798384 0.30628024491135 no 2335 0.323894449678638 3363 688959 SGTC_51 1013-0126 23.419 µM -0.457138602231757 0.306161820058205 no 2336 0.323785712865351 3447 1627850 SGTC_1868 st057644 42.7 µM -0.457195114369486 0.306139703093769 no 2337 0.323765404840097 3169 688665 SGTC_3342 9147791 14.508 µM -0.458015638521784 0.305818656969306 no 2338 0.323470602985741 3218 1838168 SGTC_769 0302-0231 76 µM -0.458140137742483 0.305769957241843 no 2339 0.323425881983193 3305 571869 YER009W NTF2 SGTC_3039 9090270 49.47 µM -0.45890121983343 0.305472323329373 no 2340 0.323152551379294 3346 17173750 SGTC_3011 9081274 71.4286 µM -0.46036121320224 0.304901728303854 no 2341 0.322628485111319 3208 6625322 SGTC_2687 chenodiol 100 µM -0.460441969049503 0.304870181105593 no 2342 0.322599507977632 3306 5702181 A cholesterol synthesis inhibitor. SGTC_3206 9114350 49.47 µM -0.461319305325651 0.304527544006512 no 2343 0.322284768160956 3289 17087243 SGTC_925 2064-1272 59.6 µM -0.46328841072676 0.30375914923711 no 2344 0.321578825852084 3219 6815817 SGTC_1051 3253-3903 78 µM -0.463936104419405 0.303506591981175 no 2345 0.321346762320214 3154 5509239 SGTC_2898 9056270 58.44 µM -0.464678957132265 0.303217044594451 no 2346 0.3210806899077 3280 19154699 SGTC_1127 asiatic acid 681.4 nM -0.465165536611503 0.3030274537586 no 2347 0.320906458321582 3186 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_86 0417-1630 471.922 µM -0.465337221414419 0.302960571150841 no 2348 0.320844991822411 3306 3634867 SGTC_1025 k007-0731 70 µM -0.466647311072452 0.302450422128597 no 2349 0.320376116043418 3179 6256118 SGTC_1313 1220-0047 237 µM -0.466806043328459 0.302388637945579 no 2350 0.320319325863119 3278 3528706 SGTC_1804 st050076 49.1 µM -0.467233288907095 0.302222367053273 no 2351 0.320166489664582 3317 3895976 SGTC_1844 rapamycin 4 nM -0.467491469991825 0.302121910776075 no 2352 0.320074146758763 3222 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2927 9011802 47.9 µM -0.467729251023401 0.302029405265949 no 2353 0.319989110141495 3316 43912568 SGTC_1945 st075991 56.6 µM -0.468110741996995 0.301881017918779 no 2354 0.319852698909144 3239 1084980 SGTC_2691 st077356 60.2 µM -0.468710733064432 0.30164770757695 no 2355 0.319638207022517 3354 2839272 SGTC_866 0495-0101 262 µM -0.468900545839819 0.301573914561328 no 2356 0.319570363067059 3221 635694 SGTC_334 1502-1024 68.5 µM -0.469036592983868 0.301521028866201 no 2357 0.319521740042274 3322 3296216 SGTC_2897 9048598 12.99 µM -0.469173207692899 0.301467926740671 no 2358 0.319472917292733 3215 6467404 SGTC_2328 6201408 200 µM -0.469217647082656 0.301450654060978 no 2359 0.31945703641821 3320 2890418 SGTC_2743 auranofin 4.32 µM -0.469325211694952 0.301408847745393 no 2360 0.319418598464827 3230 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1087 pterostilbene 9.05 µM -0.469840095632557 0.301208767897099 no 2361 0.31923463281853 3341 5281727 Similar to reservatol, lowers cholesterol. SGTC_2792 7535235 81.82 µM -0.472060672402619 0.30034655551152 no 2362 0.318441741293014 3243 1281891 SGTC_1960 st011366 51.8 µM -0.472774261343214 0.300069717981846 no 2363 0.318187119468839 3263 3972846 SGTC_1324 1418-0026 34.4 µM -0.47322025614609 0.299896752497305 no 2364 0.318028023824804 3304 1372513 SGTC_2393 9031399 185.94 µM -0.474881363251107 0.299252940180037 no 2365 0.317435767878988 3361 1526623 YDL150W RPC53 SGTC_2421 5690543 90.72 µM -0.475934035577039 0.298845270061331 no 2366 0.317060686702573 3310 3397993 SGTC_1102 cgs 12066b 26.1 µM -0.476671889946087 0.298559670520291 no 2367 0.316797891333149 3274 6438352 A 5-HT1B full agonist. SGTC_1162 k048-0130 20.1 µM -0.477345835842181 0.298298916416849 no 2368 0.316557938455875 3243 6797406 SGTC_629 3448-6466 76.7 µM -0.479384264305007 0.297510866827944 no 2369 0.315832642924476 3302 573744 SGTC_1121 fusaric acid 630.51 nM -0.481817700298399 0.296571355373697 no 2370 0.314967727132738 3223 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2308 7584454 197.62 µM -0.482853437379374 0.296171886329972 no 2371 0.314599902515939 3429 893577 SGTC_200 k038-0079 37.545 µM -0.48301667669234 0.296108949776946 no 2372 0.314541947586312 3235 3436683 SGTC_1759 st043059 70 µM -0.484298992492353 0.295614769381101 no 2373 0.314086845433768 3217 669426 SGTC_402 epigallocatechin gallate 10 µM -0.484794203195561 0.295424026018582 no 2374 0.313911167553693 3252 65064 An antioxidant. SGTC_885 0865-0106 16.8 µM -0.486172823475039 0.294893312765592 no 2375 0.313422318985045 3241 2793380 SGTC_865 0488-0499 301 µM -0.486885462509138 0.294619147836965 no 2376 0.313169750819247 3398 9634651 SGTC_348 k064-0012 10.7 µM -0.487822118449014 0.294258978566578 no 2377 0.312837921545192 3262 5066323 SGTC_2859 9028643 45.46 µM -0.48860879010035 0.293956639497601 no 2378 0.312559344343019 3300 17151580 SGTC_531 3788-1495 174 µM -0.490053334191737 0.293401836739737 no 2379 0.312048079367166 3198 2896655 SGTC_2891 9063876 19.48 µM -0.490407771544671 0.293265782949665 no 2380 0.311922689217202 3317 6472478 SGTC_459 nigericin 15.3 µM -0.492197668649942 0.292579162885662 no 2381 0.311289806199926 3393 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2296 7971656 126.45 µM -0.492453053974865 0.292481255781792 no 2382 0.3111995508552 3321 666570 SGTC_2616 abietic acid 100 µM -0.493312501106963 0.292151881336809 no 2383 0.310895898329484 3401 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3281 9140613 49.47 µM -0.493481721853396 0.292087049536297 no 2384 0.310836125860768 3312 16013766 SGTC_1571 st070080 73.4 µM -0.494853693436446 0.291561667604748 no 2385 0.310351699881598 3416 4315245 SGTC_1969 st069479 40.1 µM -0.496145378344944 0.291067433706002 no 2386 0.309895922589797 3379 3895485 SGTC_2357 9067248 200 µM -0.496768939060973 0.290828982497274 no 2387 0.309676000633544 3354 9150235 SGTC_1540 guanosine 70.6 µM -0.49832714609641 0.290233519728537 no 2388 0.309126738684446 3330 6802 Guanosine is a purine nucleoside SGTC_1009 4106-0057 9.87 µM -0.499617396073759 0.289740888379081 no 2389 0.308672253184173 3410 2928005 SGTC_1626 st003712 1.76 µM -0.502325422699368 0.288708212598104 no 2390 0.307719314532578 3390 24207035 SGTC_3335 9143315 29.6265 µM -0.502947448535961 0.288471254986533 no 2391 0.307500610057128 3281 4899691 SGTC_3244 9134489 49.47 µM -0.503155522658824 0.288392010660322 no 2392 0.307427466397822 3353 16584271 SGTC_2861 9024595 19.48 µM -0.504159360782615 0.28800984656061 no 2393 0.307074697880996 3279 16482810 SGTC_2912 7964298 10.93 µM -0.50473778087732 0.287789748955917 no 2394 0.306871510687778 3365 2975850 SGTC_311 1315-0136 58 µM -0.505858992584596 0.287363337352872 no 2395 0.306477820821093 3425 6759207 SGTC_1745 st081495 74 µM -0.507203909262539 0.286852242439777 no 2396 0.306005876178525 3375 13842402 YBL026W LSM2 SGTC_2744 captopril 92.04 µM -0.507718663933366 0.286656739548408 no 2397 0.305825328769036 3345 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_263 alizarin 107.927 µM -0.508105529945589 0.286509850138815 no 2398 0.305689668664716 3339 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_662 k832-1615 104 µM -0.509277041637692 0.286065256040311 no 2399 0.305279024011158 3353 5878478 SGTC_809 3998-0021 90 µM -0.50931015323631 0.286052694800722 no 2400 0.305267421110599 3374 715485 SGTC_308 4092-1169 104 µM -0.509707440019238 0.285902000246255 no 2401 0.305128219927097 3315 2268590 YDL196W YDL196W SGTC_322 k048-0136 19.3 µM -0.509813529426757 0.285861765937712 no 2402 0.305091053130567 3363 6823282 SGTC_3230 9131665 49.47 µM -0.510403314211362 0.285638139710637 no 2403 0.304884467737315 3321 15943720 SGTC_571 k831-0106 44.2 µM -0.511162000985581 0.285350594099015 no 2404 0.304618812067074 3393 4783639 SGTC_2441 5730946 39.09 µM -0.512899559293396 0.284692571845385 no 2405 0.304010790867302 3394 1774275 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.512908647762043 0.28468913190075 no 2406 0.304007611975693 3319 688669 SGTC_1715 st032160 10.2275 µM -0.513360150289244 0.284518265200233 no 2407 0.303849707703851 3354 5289825 SGTC_1012 4112-3522 18 µM -0.51342333656419 0.284494356882212 no 2408 0.303827612445427 3410 3112398 SGTC_2265 7929201 200 µM -0.513632596364218 0.284415184358354 no 2409 0.30375444266342 3216 1265108 SGTC_799 1310-0557 151 µM -0.515234626780272 0.283809412267641 no 2410 0.30319453743662 3427 5354492 SGTC_560 2332-1943 155 µM -0.515636994304348 0.283657363069835 no 2411 0.303053983636512 3386 21177716 SGTC_165 k038-0023 64.381 µM -0.515891381577104 0.283561253727118 no 2412 0.302965136891634 3315 46368543 SGTC_2035 5154463 94.595 µM -0.515992626802099 0.283523006893624 no 2413 0.302929779448169 3423 2769623 SGTC_158 k038-0087 26.446 µM -0.516779698643181 0.283225763576585 no 2414 0.302654976677629 3272 X158 SGTC_84 0443-0269 128.823 µM -0.518146782039053 0.282709830337664 no 2415 0.302177931046729 3384 6150058 SGTC_2603 homopterocarpin 100 µM -0.518529618583704 0.282565429938639 no 2416 0.302044400223194 3392 101795 A weak amylase inhibitor. SGTC_1444 4112-3581 28 µM -0.519296482576909 0.282276286642645 no 2417 0.301777002932005 3386 2877249 SGTC_746 1095-0025 46.6 µM -0.519730366715484 0.282112755286649 no 2418 0.301625759314376 3443 6749286 SGTC_486 niguldipine 82 µM -0.519945417015253 0.282031719528246 no 2419 0.301550809578416 3339 1236 A calcium channel blocker. SGTC_1727 st034309 9.9045 µM -0.521009753087555 0.281630819032396 no 2420 0.301179988583914 3474 870305 SGTC_1357 1503-1303 39.5 µM -0.521101058983117 0.28159643989824 no 2421 0.301148186638722 3355 292895 SGTC_1440 4100-1550 40 µM -0.521779598058485 0.281341015051364 no 2422 0.300911898139408 3366 742806 SGTC_1020 4335-0961 93.3 µM -0.522534686636215 0.281056905938708 no 2423 0.300649051045077 3234 669075 SGTC_3204 9114183 49.47 µM -0.522667801418505 0.281006834637247 no 2424 0.300602724403071 3298 17027248 SGTC_601 0986-0029 62.9 µM -0.523742771093279 0.280602641403781 no 2425 0.300228731329756 3375 24747981 SGTC_480 am 92016 50 µM -0.525661702502964 0.279881814960032 no 2426 0.299561638714597 3362 2129 K+ channel blocker. SGTC_133 0724-0033 378.92 µM -0.526191274165677 0.279683045156736 no 2427 0.299377658059083 3264 280309 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.528546785382476 0.278799756892236 no 2428 0.298559941874967 3447 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1381 2324-0066 62.1 µM -0.529106043382626 0.278590241509196 no 2429 0.298365944684943 3381 10885928 SGTC_513 4245-1575 41.7 µM -0.529269481897381 0.278529026857664 no 2430 0.298309261450114 3339 719745 SGTC_2497 7-hydroxyflavone 100 µM -0.529339852233747 0.278502672201889 no 2431 0.298284857339954 3424 5281894 SGTC_2438 5259590 200 µM -0.53104941943152 0.277862789368612 no 2432 0.297692266771154 3387 1201127 SGTC_2168 5727979 200 µM -0.531424999270979 0.277722307845958 no 2433 0.297562150811967 3368 695210 SGTC_2526 patulin 37.61 µM -0.532373545133628 0.277367669166547 no 2434 0.29723365201916 3441 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1168 k815-0004 80.5 µM -0.533122706293105 0.277087732262282 no 2435 0.296974321004678 3309 642433 SGTC_985 1493-0307 8.71 µM -0.533545834995835 0.276929684095591 no 2436 0.296827895743763 3456 3278274 SGTC_1850 st056238 17 µM -0.534005279658095 0.276758121094862 no 2437 0.296668940640662 3412 5393177 SGTC_627 1391-0720 175 µM -0.534581274125048 0.276543110368006 no 2438 0.29646971762903 3363 997839 SGTC_1520 flindersine 88 µM -0.53670817943484 0.275749876390377 no 2439 0.295734602598026 3509 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1557 sumaresinolic acid 42.3 µM -0.536808465217967 0.275712502213246 no 2440 0.295699961850628 3357 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1291 0993-0025 5.79 µM -0.537842091518911 0.275327438898031 no 2441 0.295343035026475 3468 4353356 SGTC_2881 9058953 51.95 µM -0.539256142056576 0.274801082821094 no 2442 0.294855063323341 3321 17122249 SGTC_2006 4011487 200 µM -0.539358532810168 0.274762988886286 no 2443 0.294819743948492 3473 45595294 SGTC_1681 tripelennamine 100 µM -0.540769069221487 0.274238471458151 no 2444 0.294333382388418 3436 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2856 9022925 19.48 µM -0.541140507296467 0.274100432013727 no 2445 0.29420536993105 3408 4944862 SGTC_265 mycophenolic acid 32.932 µM -0.541169057843618 0.274089823047777 no 2446 0.294195531332098 3537 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_646 4092-0839 27.3 µM -0.541674332709716 0.273902103866544 no 2447 0.294021437345939 3486 877796 SGTC_1632 st005650 90 µM -0.543533741619656 0.273211846036747 no 2448 0.293381182867155 3401 2759605 SGTC_2748 diazoxide 86.69 µM -0.543602913173764 0.273186184508827 no 2449 0.293357377336987 3374 3019 A potassium channel activatior. SGTC_194 1486-1323 56.904 µM -0.545409898739636 0.272516245480341 no 2450 0.292735816955495 3397 5178754 SGTC_1341 1486-1360 280 µM -0.545753735217684 0.272388860710276 no 2451 0.292617614616448 3331 3976547 SGTC_2940 9060638 45.86 µM -0.546497629284043 0.272113363590919 no 2452 0.292361958445123 3405 4027022 SGTC_2741 miltefosine 3.04 µM -0.547571772225187 0.271715805174929 no 2453 0.291992988087297 3334 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_552 k242-0005 476 µM -0.54848813624349 0.271376872086113 no 2454 0.291678386601769 3457 4088318 SGTC_1604 st002052 72.4 µM -0.548495866275858 0.27137401389616 no 2455 0.291675733438063 3481 6254834 YHR062C RPP1 SGTC_2652 actinonin 100 µM -0.548738656174965 0.271284249636685 no 2456 0.291592406867552 3392 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1486 3970-0793 4.53 µM -0.549679115906114 0.270936682701213 no 2457 0.291269741725936 3448 2844330 SGTC_198 3454-2873 16.191 µM -0.551454297488945 0.270281232618812 no 2458 0.290661143986617 3378 710957 SGTC_3288 9119690 36.221 µM -0.553852707727047 0.269396928879636 no 2459 0.289839826493841 3382 17595618 YKL019W RAM2 SGTC_1182 1222-0449 220 µM -0.553920150755812 0.269372083340503 no 2460 0.289816746882506 3421 658318 SGTC_2611 pyromycin 23.93 µM -0.554279831813066 0.269239598764548 no 2461 0.289693675350226 3358 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2727 riluzole 51.77 µM -0.554446791299157 0.269178112176029 no 2462 0.289636555407798 3443 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2789 5281112 71.43 µM -0.555227542045924 0.268890676667691 no 2463 0.28936951626201 3380 765948 SGTC_2113 5491891 107.031 µM -0.555286944441005 0.268868813825214 no 2464 0.289349203675676 3409 789979 SGTC_3049 9092223 49.47 µM -0.555365214798944 0.268840008058433 no 2465 0.28932244023238 3424 8623917 SGTC_1675 st018485 24.5 µM -0.555429523058758 0.268816341909477 no 2466 0.289300451801886 3386 3323024 SGTC_2854 9024559 71.43 µM -0.555951417453557 0.26862431772624 no 2467 0.289122033506377 3411 3163529 SGTC_2666 tannic acid 100 µM -0.557136832850228 0.268188415965394 no 2468 0.288716971854404 3477 16134267 A thiamine antagonist. SGTC_2044 5102272 200 µM -0.557951430904809 0.267889077888587 no 2469 0.288438775124409 3447 592666 SGTC_246 cycloheximide 667 µM -0.557962740455988 0.267884923184005 no 2470 0.288434913642524 3361 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1241 0364-0022 50.8 µM -0.558876590059919 0.267549316440075 no 2471 0.288122973539351 3381 4563895 SGTC_1198 1612-1005 86.7 µM -0.560119515010985 0.267093198888006 no 2472 0.287698960121923 3534 6998509 SGTC_844 0330-0132 15.3 µM -0.560149577953358 0.267082171521263 no 2473 0.287688708054608 3488 2828079 SGTC_598 3937-0236 20.2 µM -0.561633077193366 0.266538295917704 no 2474 0.287183019593225 3461 1379313 SGTC_202 3594-0513 34.79 µM -0.562257655485868 0.266309482749659 no 2475 0.286970242129502 3426 708429 SGTC_2569 tetrandrine 100 µM -0.563220412575698 0.265956973195309 no 2476 0.286642402364722 3360 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.563562190849233 0.265831889365075 no 2477 0.286526062149565 3460 17037758 SGTC_3349 9149703 23.001 µM -0.566879582463958 0.264619343362838 no 2478 0.285397998424526 3467 4910494 SGTC_1413 3910-0535 34.4 µM -0.567542179794367 0.264377493694186 no 2479 0.28517293892188 3472 2876951 SGTC_763 3453-1109 128 µM -0.569501983711396 0.263662819576785 no 2480 0.284507762444708 3509 1560353 SGTC_3050 9093513 49.47 µM -0.569933567816782 0.263505567987093 no 2481 0.284361378241362 3483 25236664 SGTC_2377 9073351 62.6 µM -0.570569736575151 0.263273861430692 no 2482 0.28414566890133 3386 7337946 YHR072W ERG7 SGTC_1941 st076221 61.8 µM -0.572241022627817 0.262665638710706 no 2483 0.283579349611785 3432 2828568 SGTC_2380 9035439 200 µM -0.572836640866049 0.262449052257121 no 2484 0.283377653731078 3544 6462575 SGTC_209 4077-0173 175.592 µM -0.573441364874706 0.262229248224169 no 2485 0.283172944729095 3428 15993494 SGTC_918 glabranin 770.725 nM -0.575608824961375 0.261442199125099 no 2486 0.282439807362683 3457 124049 Also referred to as licorice root. SGTC_1886 st057356 49.9 µM -0.576872273386917 0.260983975425792 no 2487 0.282012871010336 3370 24207747 SGTC_1976 st070609 63.5 µM -0.578325361760321 0.260457484732982 no 2488 0.281522237372484 3449 682556 SGTC_1757 st041620 31.8375 µM -0.580050973054508 0.259832963322133 no 2489 0.280940122060977 3470 5289815 SGTC_1469 k284-2957 126 µM -0.580154788034757 0.259795415969628 no 2490 0.280905119820635 3465 23884841 SGTC_2708 st078559 56 µM -0.580627692086006 0.259624413510885 no 2491 0.280745702251408 3440 17250902 SGTC_1971 st069429 63.5 µM -0.581991761845255 0.25913149060159 no 2492 0.280286114958989 3488 1246522 YGL099W LSG1 SGTC_1563 conessine 56.1 µM -0.582348374251087 0.259002704272855 no 2493 0.280166023938029 3535 441082 An anti-amoebic, histamine inhibitor. SGTC_2011 4012611 177 µM -0.583309921041305 0.258655618121284 no 2494 0.279842342517756 3452 2049887 SGTC_2013 4024628 200 µM -0.583360747694613 0.258637278106593 no 2495 0.279825238005575 3520 5230760 SGTC_2356 9061756 188.97 µM -0.58454429115624 0.258210405136112 no 2496 0.279427087811118 3451 20104043 SGTC_2836 9010338 19.48 µM -0.584669296951996 0.258165340170209 no 2497 0.279385051280502 3381 2994051 SGTC_2808 7946468 45.46 µM -0.584763306035387 0.258131452299036 no 2498 0.279353440244527 3460 2970879 SGTC_484 loperamide 105 µM -0.58537913880566 0.257909517384882 no 2499 0.279146406305061 3441 3955 An opioid-receptor agonist. SGTC_635 k038-0028 24.7 µM -0.585506331482376 0.257863691799174 no 2500 0.279103655289772 3454 4035102 SGTC_557 1315-0110 16.2 µM -0.586340291074624 0.257563333552292 no 2501 0.278823430154381 3481 6833801 SGTC_2738 aclarubicin 5.55 µM -0.586926813656848 0.257352200912453 no 2502 0.278626430265293 3405 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2201 6605497 169.863 µM -0.586979014422062 0.257333414375116 no 2503 0.278608900474597 3472 670741 SGTC_1877 wortmannin 25 µM -0.58777981244427 0.257045304471305 no 2504 0.278340047969816 3526 312145 A covalent inhibitor of PI 3-kinase. SGTC_2926 9010726 65.15 µM -0.58790086871365 0.25700176563251 no 2505 0.27829941666569 3485 2994293 SGTC_820 1582-0060 59.9 µM -0.590257031468974 0.256155117770576 no 2506 0.277509170946046 3421 3848840 SGTC_2450 5739737 12.93 µM -0.5909393718128 0.255910202001149 no 2507 0.277280522213358 3496 2262825 SGTC_2505 galangin 7.89 µM -0.59099306349722 0.255890935368623 no 2508 0.277262534317694 3428 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_920 mycophenolic acid 780.421 nM -0.591873131801327 0.255575241082874 no 2509 0.276967773448688 3442 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2933 9026794 32.47 µM -0.592932632709363 0.255195451567474 no 2510 0.276613118945992 3438 17586027 SGTC_2974 9094440 9.66 µM -0.593082435460917 0.255141776980071 no 2511 0.276562992339364 3543 25236134 SGTC_14 0354-0009 295 µM -0.59316953310409 0.255110572456977 no 2512 0.27653385000009 3523 1713507 SGTC_3021 9087658 49.47 µM -0.594096365218388 0.254778639455384 no 2513 0.276223830919108 3513 25237042 SGTC_2403 6032726 181.2 µM -0.596115702238758 0.254056223602626 no 2514 0.275548967525765 3473 2881040 SGTC_3261 9137475 49.47 µM -0.596895793929918 0.253777434583533 no 2515 0.275288477815035 3405 17027690 SGTC_2240 6690706 185.951 µM -0.597742827887194 0.253474903734991 no 2516 0.275005771938105 3431 805876 SGTC_2617 dihydrotanshinone i 20.83 µM -0.597870866668002 0.253429189263308 no 2517 0.274963050188622 3498 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3314 9135860 59.4275 µM -0.599501406064536 0.252847406916522 no 2518 0.274419286363298 3527 25252478 SGTC_1248 0469-0687 58.6 µM -0.599938225127863 0.252691667784222 no 2519 0.274273703038791 3487 4017482 SGTC_1669 st015249 58.4 µM -0.600509112720426 0.252488205370401 no 2520 0.274083494781793 3568 722793 SGTC_716 1683-5115 658 µM -0.600948533582785 0.252331656071527 no 2521 0.273937132996184 3562 723597 SGTC_1560 lithocholic acid 53.1 µM -0.603332936231183 0.251483075104756 no 2522 0.273143613195275 3479 9903 A bile acid which acts as a detergent. SGTC_414 piperonyl butoxide 100 µM -0.604032302366591 0.251234465222366 no 2523 0.272911083135649 3441 5794 A potent inhibitor of cytochrome P450. SGTC_1506 4226-2149 212 µM -0.604795616913274 0.250963271435573 no 2524 0.272657403160992 3505 991114 SGTC_1716 st033144 30.6155 µM -0.604898883491579 0.250926594327018 no 2525 0.272623092533276 3562 674617 SGTC_343 4130-2827 29.8 µM -0.607289726063094 0.250078234445021 no 2526 0.271829327661478 3490 1118244 SGTC_670 4204-0025 119 µM -0.607774176028171 0.249906519165327 no 2527 0.271668629460206 3500 719039 SGTC_3141 9094609 49.47 µM -0.608700781096832 0.2495782545975 no 2528 0.27136139459995 3433 25236309 YDL196W YDL196W SGTC_1678 st019265 80.2 µM -0.609809493153302 0.249185776964818 no 2529 0.270994006113391 3583 5367020 SGTC_2585 alliin 100 µM -0.610062296437455 0.249096332047315 no 2530 0.27091027068045 3622 87310 A garlic compound which reacts with lipids. SGTC_368 fentichlor 4.58 µM -0.610138608405967 0.249069335288742 no 2531 0.270884996585078 3472 7329 A pesticide. SGTC_3162 9099653 49.47 µM -0.61032642132075 0.249002899655526 no 2532 0.270822799014672 3516 25237511 SGTC_2131 toluylene red 5.2905 µM -0.611387506774055 0.248627735864438 no 2533 0.270471535745182 3487 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2513 baicalein 25.65 µM -0.611624487446892 0.248543988693985 no 2534 0.270393116430193 3489 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_425 3825-7017 13.1 µM -0.611881268256046 0.248453261273898 no 2535 0.270308157878398 3583 3397440 SGTC_3061 glucosamine 200 µM -0.612707964424246 0.248161287673159 no 2536 0.270034727689736 3491 91431 and experimental redox chemotherapeutic SGTC_113 0099-0221 2.5 µM -0.613483336423684 0.247887607207485 no 2537 0.269778398830533 3590 89219 SGTC_1220 1838-0075 193 µM -0.613623662223907 0.24783809409995 no 2538 0.269732021796455 3508 5529645 SGTC_1302 1159-0335 255 µM -0.61462917274756 0.247483460313319 no 2539 0.269399822032218 3533 649284 SGTC_2923 7992654 58.14 µM -0.614845904404926 0.247407056701709 no 2540 0.269328245280024 3539 2985126 SGTC_296 1222-0039 74.9 µM -0.614854386244435 0.247404066886473 no 2541 0.269325444302517 3504 5984176 SGTC_2698 st077697 67.5 µM -0.616356983864113 0.246874711968292 no 2542 0.268829468636816 3469 3154499 SGTC_1816 st051957 91.6 µM -0.616489908790583 0.246827912625222 no 2543 0.268785615026885 3536 674121 SGTC_3299 9121982 43.1275 µM -0.618725372399804 0.246041577157223 no 2544 0.268048646154231 3513 17594604 YPL160W CDC60 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.620455584526404 0.245433890249969 no 2545 0.26747894353391 3539 688788 SGTC_2525 harmine 47.85 µM -0.620694940835621 0.245349886827218 no 2546 0.267400179386416 3486 5280953 A monoamine oxidase inhibitor SGTC_1521 st012942 49.4 µM -0.62105989098332 0.245221835300342 no 2547 0.267280109033751 3556 24207259 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.621213282305509 0.245168024997309 no 2548 0.267229650673127 3552 229346 A bile salt which induces apoptosis. SGTC_3030 9087619 49.47 µM -0.621939380726657 0.244913392892368 no 2549 0.266990864505024 3512 25236973 SGTC_1226 3909-7979 35.4 µM -0.622610742361933 0.244678082861006 no 2550 0.266770175107761 3558 6615510 SGTC_778 3456-2434 196 µM -0.622738342589036 0.244633373175314 no 2551 0.266728240903523 3549 5539063 SGTC_3006 9075424 71.4286 µM -0.62338806188217 0.244405787087215 no 2552 0.266514770543961 3495 7465181 SGTC_717 1532-0246 73.2 µM -0.624234071405027 0.244109614812304 no 2553 0.266236937064072 3527 9561992 SGTC_3218 9131285 49.47 µM -0.624292973233141 0.244089001582014 no 2554 0.266217598889067 3604 17156417 SGTC_2326 6164455 177.58 µM -0.625054663819396 0.243822525618037 no 2555 0.265967590823222 3518 2888790 SGTC_1655 st012546 55.1 µM -0.625174221778128 0.243780712761092 no 2556 0.265928359374156 3525 720985 YLR208W SEC13 SGTC_1524 corynanthine 62.1 µM -0.625318060927432 0.243730413203183 no 2557 0.26588116424204 3580 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1667 st014849 34.6 µM -0.62720701778958 0.243070378240104 no 2558 0.265261771826119 3583 5348460 SGTC_2062 5245942 200 µM -0.628240057955885 0.242709825011886 no 2559 0.2649233461935 3625 1376160 SGTC_3096 9117468 49.47 µM -0.629182712948419 0.242381070947829 no 2560 0.264614722474984 3479 41316311 SGTC_2685 mycophenolic acid 18.85 µM -0.631091434997357 0.241716137310915 no 2561 0.263990370531073 3520 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1830 st055982 50.3 µM -0.632961809377665 0.241065524368494 no 2562 0.263379291408969 3546 455313 An antimicrobial agent. SGTC_2295 7971645 200 µM -0.633542406349801 0.240863756550057 no 2563 0.263189748737422 3538 2978226 YKL099C UTP11 SGTC_139 0099-0334 718.624 µM -0.63437516241642 0.240574519404028 no 2564 0.262918007483432 3609 97690 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.635269543010745 0.240264089234683 no 2565 0.262626317031908 3634 688751 SGTC_2553 4-methylesculetin 85.09 µM -0.635593991945942 0.240151530371068 no 2566 0.262520543231262 3560 5319502 SGTC_1961 st076550 68.7 µM -0.635850912299265 0.240062419134481 no 2567 0.262436799939034 3557 1579337 SGTC_2290 7904846 200 µM -0.635883221365689 0.240051214210671 no 2568 0.2624262697541 3564 2962154 SGTC_2096 5468907 200 µM -0.63787769324219 0.239360075134069 no 2569 0.261776649751502 3565 759785 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.638111702984809 0.239279055658634 no 2570 0.261700484480502 3547 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_292 k038-0015 474 µM -0.638930787615782 0.238995588033719 no 2571 0.261433979169286 3567 46368540 SGTC_170 4197-0004 226 µM -0.639083894289236 0.23894262147239 no 2572 0.261384178363423 3575 218692 SGTC_1677 st019204 53.9 µM -0.639548163898377 0.238782048749812 no 2573 0.261233195792376 3544 3945625 SGTC_3356 9151811 4.48 µM -0.640320287095882 0.238515132267217 no 2574 0.260982197116129 3550 1859254 YPR165W RHO1 SGTC_63 0099-0242 26.702 µM -0.640406840785836 0.238485221570322 no 2575 0.260954068325367 3576 3898502 YLR359W ADE13 SGTC_445 e6 berbamine 66 µM -0.642402927113605 0.237795996289966 no 2576 0.260305799825083 3601 6610268 A calcium/calmodulin antagonist. SGTC_2939 9044578 71.43 µM -0.644075345938446 0.237219371765805 no 2577 0.25976328828312 3562 2653634 SGTC_1399 3562-5772 25 µM -0.644695885108368 0.237005614838917 no 2578 0.25956214172732 3546 23847490 SGTC_232 clozapine 119 µM -0.645216404543512 0.236826393352074 no 2579 0.259393478418446 3562 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2775 cyproheptadine 69.59 µM -0.645582716808942 0.236700312051341 no 2580 0.259274816631398 3621 2913 A selective serotonin reuptake inhibitor. SGTC_691 1548-0686 185 µM -0.646356650136821 0.236434052791232 no 2581 0.259024203919642 3553 46495133 SGTC_176 1486-1328 72.834 µM -0.647584466045721 0.236011981007053 no 2582 0.258626873524201 3585 22310231 SGTC_43 0570-0105 72.5 µM -0.648232946226936 0.235789228290025 no 2583 0.258417147915059 3626 1114046 YDL195W SEC31 SGTC_1620 st003704 16.5 µM -0.649647877311617 0.235303602589549 no 2584 0.257959849714844 3587 2834414 SGTC_3287 9117173 37.0625 µM -0.650817103093362 0.234902723676354 no 2585 0.257582279190003 3565 2789709 SGTC_1633 st005664 67.9 µM -0.651544142807043 0.234653642420041 no 2586 0.257347645752693 3595 2063822 SGTC_3177 9107506 49.47 µM -0.652286032034148 0.234399624403585 no 2587 0.257108334562644 3558 8897194 SGTC_2242 6630449 61.2675 µM -0.652966480990906 0.234166776978359 no 2588 0.256888943952022 3587 691249 YDR170C SEC7 SGTC_1049 3226-0134 66 µM -0.653234151302322 0.234075216177404 no 2589 0.256802668294039 3626 5702385 SGTC_3219 9131112 49.47 µM -0.653421148537561 0.23401126262528 no 2590 0.256742404180845 3544 17612988 YMR079W SEC14 SGTC_1129 3453-1384 223 µM -0.654840310848296 0.233526220925284 no 2591 0.256285286910281 3653 1084452 SGTC_395 anisomycin 6.25 µM -0.655822571311425 0.233190830451024 no 2592 0.255969145913754 3561 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_807 1315-0151 48 µM -0.657407335352646 0.232650280709845 no 2593 0.255459518134764 3657 4011080 SGTC_2612 dictamnine 15.46 µM -0.658243425749788 0.232365378183858 no 2594 0.255190862317021 3554 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_849 0386-0493 241 µM -0.65971688024498 0.231863762960054 no 2595 0.254717766039576 3566 726119 SGTC_2735 sertaconazole 140 nM -0.661462216519223 0.231270370846599 no 2596 0.254157968801716 3660 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_504 lovastatin 124 µM -0.662068061751896 0.231064589420735 no 2597 0.253963801635348 3569 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1047 2043-3044 82 µM -0.662336469792346 0.230973454607571 no 2598 0.253877804506834 3605 669592 SGTC_1891 st059073 26.2 µM -0.662673483285123 0.230859054035685 no 2599 0.253769848045544 3655 688754 SGTC_301 4119-0100 24.5 µM -0.663845237902931 0.230461543624849 no 2600 0.253394684323507 3624 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1207 2099-0101 141 µM -0.665671681558197 0.229842697738738 no 2601 0.252810488943538 3629 5837381 SGTC_1591 genipin 88.4 µM -0.666256225501399 0.229644835984068 no 2602 0.252623670094784 3614 442424 A DNA cross-linking agent. SGTC_2976 9009005 19.48 µM -0.667384067239513 0.229263343620445 no 2603 0.252263420178433 3643 2993148 SGTC_1906 st060206 94.7 µM -0.672201029519364 0.227638012477653 no 2604 0.250727862840441 3624 5133468 SGTC_1296 1068-0102 11.9 µM -0.672795658209875 0.227437824696914 no 2605 0.250538650172691 3604 767053 SGTC_1979 st071809 45.3 µM -0.674277492942032 0.226939381729336 no 2606 0.250067455210722 3691 4976333 SGTC_1389 3405-0187 19 µM -0.674386047998917 0.226902891430549 no 2607 0.250032955281269 3580 799890 SGTC_1153 4055-0057 267 µM -0.67571512055403 0.226456398000687 no 2608 0.249610766977465 3640 882706 SGTC_2830 7992007 71.43 µM -0.676424783947948 0.226218194441775 no 2609 0.2493854930922 3578 1952075 SGTC_1237 0330-0133 46.1 µM -0.677117821229385 0.225985708249667 no 2610 0.249165601304147 3595 X1237 YHR072W ERG7 SGTC_1315 1237-0019 3.69 µM -0.677486180716458 0.225862193423794 no 2611 0.249048767576611 3627 825140 SGTC_401 neomycin 50 µM -0.679694567686978 0.225122498974002 no 2612 0.248348938198616 3614 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3320 9137005 35.139 µM -0.680294013937963 0.22492195283568 no 2613 0.248159157031755 3628 4908713 SGTC_1092 toremifene 6.32 µM -0.685757169416089 0.223098915039835 no 2614 0.246433124616331 3657 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2396 5342950 42.78 µM -0.686547735798664 0.222835804148414 no 2615 0.246183886560451 3655 1886677 SGTC_2426 5582046 32.21 µM -0.687225761464029 0.222610289195126 no 2616 0.245970236403715 3656 2251934 SGTC_1344 1488-0097 29.1 µM -0.688509685019281 0.222183606032404 no 2617 0.245565936728087 3639 747966 SGTC_1018 4259-0013 28.1 µM -0.688902789576776 0.222053059946524 no 2618 0.24544222192409 3663 6801262 SGTC_228 caffeine 993.056 µM -0.689298601100095 0.221921659156795 no 2619 0.2453176890505 3664 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1885 st057546 99.9 µM -0.689621734922506 0.221814418708136 no 2620 0.245216047709584 3709 702008 SGTC_874 0599-0792 117 µM -0.692788370337306 0.220765055190244 no 2621 0.244221185787188 3688 765305 SGTC_2174 5790901 200 µM -0.693424397848397 0.220554630992842 no 2622 0.244021627762015 3679 786020 SGTC_2831 7999036 19.48 µM -0.693899208879032 0.220397618818332 no 2623 0.243872709882794 3665 2988270 SGTC_1789 tunicamycin 25 nM -0.694297347449845 0.2202660103613 no 2624 0.243747877067298 3650 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2776 terbinafine 19.92 µM -0.694603000502504 0.220165004446675 no 2625 0.243652065675848 3679 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3133 9127736 49.47 µM -0.696257051858841 0.219618868724435 no 2626 0.243133932206369 3669 27243420 SGTC_1232 0279-0259 161 µM -0.696920195095642 0.219400130343442 no 2627 0.242926369267719 3696 1560000 SGTC_961 1252-1571 372 µM -0.69743964855889 0.219228875627938 no 2628 0.242763848017149 3674 6813498 SGTC_289 k017-0060 526 µM -0.699353683212887 0.218598515488874 no 2629 0.242165512827619 3658 5512909 SGTC_831 k061-1017 217 µM -0.700086330870026 0.218357504810296 no 2630 0.241936695883886 3726 1240153 SGTC_1393 3470-5649 58.2 µM -0.703095353133358 0.217369268048674 no 2631 0.240998163936864 3628 4108395 SGTC_2246 7293507 91.5585 µM -0.703916013746534 0.217100191854921 no 2632 0.240742539078928 3730 887656 SGTC_1723 st034307 2.5525 µM -0.704578747961392 0.216883036714159 no 2633 0.24053621393396 3725 867466 SGTC_1240 0356-0016 42.1 µM -0.705069167529934 0.216722424009737 no 2634 0.240383596502344 3677 4305613 SGTC_94 0334-0113 514.748 µM -0.705207182567176 0.216677236407668 no 2635 0.240340656055949 3646 6795178 SGTC_2048 5246248 200 µM -0.705596991991686 0.216549638060078 no 2636 0.240219397708082 3674 677046 SGTC_2455 5377712 9.75 µM -0.706050540412775 0.216401230426188 no 2637 0.240078353989406 3647 2243908 SGTC_1654 st012436 41.8 µM -0.706718203637666 0.216182868460235 no 2638 0.239870807386033 3651 4323132 SGTC_181 1447-1644 8.07 µM -0.7072597122022 0.216005859631713 no 2639 0.23970254852214 3648 534600 SGTC_2101 5377231 179.231 µM -0.709829325275442 0.215167047428321 no 2640 0.238904990749934 3700 2844213 SGTC_1797 st048695 56.8 µM -0.710054586689482 0.215093604421508 no 2641 0.238835143253483 3653 592262 YIL048W NEO1 SGTC_2072 5231554 129 µM -0.710400020349624 0.214981009385018 no 2642 0.238728055281299 3751 789545 SGTC_2144 5628481 200 µM -0.710419902154938 0.21497452989865 no 2643 0.238721892517671 3684 2818399 SGTC_1278 0874-0585 172 µM -0.710841938592491 0.214837014853691 no 2644 0.238591094410748 3736 766306 SGTC_1931 st074438 57.1 µM -0.711209836080319 0.214717181976481 no 2645 0.23847710712753 3663 2787313 SGTC_2712 st079126 47.7 µM -0.711760070878864 0.214538030048796 no 2646 0.238306681136101 3679 3152970 SGTC_2678 equilin 100 µM -0.713513368925281 0.213967750548758 no 2647 0.237764071723265 3708 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2140 5586273 200 µM -0.713905770090121 0.213840238705231 no 2648 0.237642724568543 3678 854421 SGTC_2674 ligustilide 100 µM -0.713972686309053 0.213818498512035 no 2649 0.237622034615356 3686 5319022 A signalling regulator. SGTC_1507 4075-3230 155 µM -0.714689428132672 0.213585719325145 no 2650 0.237400485850243 3624 659771 SGTC_1772 st048439 82.2 µM -0.714797156509563 0.213550744706688 no 2651 0.237367196234462 3690 2927068 YDL195W SEC31 SGTC_1657 st012939 43.4 µM -0.715191746439104 0.213422667386898 no 2652 0.2372452841698 3710 24207257 SGTC_3179 9107801 49.47 µM -0.715934178171426 0.213181807824007 no 2653 0.237015996548762 3706 4818259 SGTC_411 enrofloxacin 100 µM -0.716419286520804 0.213024514736118 no 2654 0.236866244761363 3759 71188 A bacterial gyrase inhibitor. SGTC_1845 st056753 3.01 µM -0.7168697976956 0.212878500205672 no 2655 0.236727219640161 3674 5375839 SGTC_1429 4049-0205 9.46 µM -0.717764623425464 0.212588652819845 no 2656 0.236451214788403 3721 22774478 SGTC_525 k781-2675 26.7 µM -0.717873066148252 0.21255354227189 no 2657 0.236417778170207 3734 3651118 YDL195W SEC31 SGTC_364 0083-0097 67.7 µM -0.720826515611662 0.211598605630943 no 2658 0.235508129629004 3749 5207356 SGTC_1268 0828-0275 2.46 µM -0.72087240520831 0.21158378802354 no 2659 0.235494011101626 3764 745337 SGTC_2024 5144227 134 µM -0.722695890776295 0.210995482038371 no 2660 0.234933370356124 3749 3475211 SGTC_2913 7966556 36.57 µM -0.724440047591555 0.210433667967181 no 2661 0.234397810520866 3634 2976516 SGTC_1410 3909-8106 77.9 µM -0.72543195209642 0.210114555573129 no 2662 0.23409353847687 3725 1039210 SGTC_1174 0739-0097 51.1 µM -0.726225320471091 0.209859520340602 no 2663 0.233850325989094 3736 728447 SGTC_2053 5265679 138 µM -0.726554213024922 0.209753848313824 no 2664 0.233749542803577 3694 764595 SGTC_2112 5488546 200 µM -0.726707028542497 0.209704759869485 no 2665 0.233702723440272 3705 600757 SGTC_137 0438-0332 85.389 µM -0.727844422739693 0.20933961063684 no 2666 0.233354413894449 3744 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.727862409202673 0.209333839266659 no 2667 0.233348908130207 3778 6728940 SGTC_3101 9120531 49.47 µM -0.728768892743281 0.209043094482495 no 2668 0.233071521452837 3758 24824904 SGTC_1123 mangostin 811.285 nM -0.729968941886776 0.208658557746116 no 2669 0.232704584619208 3735 5281650 An antioxidant. SGTC_2977 9011197 71.43 µM -0.730902082448985 0.208359836001242 no 2670 0.232419481973209 3732 2704722 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.732090771840037 0.207979672224139 no 2671 0.2320565829745 3694 61125 An anti-inflammatory. SGTC_1297 1068-0111 14.1 µM -0.732197655535221 0.207945509016038 no 2672 0.232023967554778 3680 767057 SGTC_1824 st053723 68.6 µM -0.732866623937927 0.207731762093298 no 2673 0.231819890708846 3704 675225 SGTC_586 0957-0265 8.15 µM -0.734033051787233 0.207359378905328 no 2674 0.23146429716581 3613 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3047 9092122 49.47 µM -0.734191372423949 0.207308865330563 no 2675 0.231416055483801 3704 17173831 SGTC_1693 xanthone 101.9 µM -0.734794862922594 0.207116383182757 no 2676 0.231232218080999 3789 7020 An insecticide. SGTC_565 1418-0001 44.5 µM -0.735025313741828 0.207042909234412 no 2677 0.231162038842395 3763 2862145 SGTC_722 3534-0461 190 µM -0.735516108809119 0.206886481909327 no 2678 0.23101261652896 3718 658262 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.735765732898482 0.20680694799318 no 2679 0.230936639288554 3698 5355888 SGTC_31 0508-1974 57.237 µM -0.737750398147856 0.20617524867338 no 2680 0.230333070083382 3690 6810525 SGTC_647 0140-0236 81 µM -0.738031558080303 0.206085850845941 no 2681 0.230247636131949 3739 990837 SGTC_1438 4092-1045 4 µM -0.738301791093044 0.205999949016665 no 2682 0.230165539167443 3726 1351342 SGTC_314 1671-0008 2.74 µM -0.740807744567752 0.205204367107272 no 2683 0.229405009371258 3679 3913060 SGTC_501 nsc-95397 161 µM -0.741044268062484 0.205129370806655 no 2684 0.229333299863839 3748 262093 SGTC_2219 9098279 200 µM -0.74169664489991 0.204922601167594 no 2685 0.229135576530256 3711 902349 SGTC_622 1348-1566 26.3 µM -0.744329145027843 0.20408949488585 no 2686 0.228338686612082 3799 7340407 SGTC_3248 9135562 49.47 µM -0.744521933368585 0.204028562626498 no 2687 0.228280388501667 3771 17650701 SGTC_3178 9107506 49.47 µM -0.745363973523989 0.203762556339145 no 2688 0.228025858387618 3763 8897194 SGTC_1257 0669-0121 16 µM -0.745437557609914 0.203739320446433 no 2689 0.228003623132568 3775 4307855 SGTC_1838 st055369 84.5 µM -0.746172302760001 0.203507394161219 no 2690 0.2277816685752 3733 676036 SGTC_2272 7805186 180 µM -0.747219398276649 0.203177145056863 no 2691 0.227465568285535 3714 2956062 YPR165W RHO1 SGTC_1130 3454-2858 15.9 µM -0.747942864343524 0.202949154180751 no 2692 0.227247310617812 3792 715628 YIL048W NEO1 SGTC_297 0986-0032 24 µM -0.748196677568488 0.202869204479599 no 2693 0.227170767368142 3737 2847425 SGTC_2890 9046729 58.44 µM -0.748410265775564 0.202801940006704 no 2694 0.227106366164802 3689 903329 SGTC_460 trequinsin 123 µM -0.749431332306131 0.202480563790939 no 2695 0.226798636020425 3800 5537 A vasodilator. SGTC_2484 5809818 12.04 µM -0.749670611950663 0.202405295632554 no 2696 0.226726555699575 3762 2870548 SGTC_2710 st078562 53.7235 µM -0.751332070428091 0.201883126377779 no 2697 0.226226416538692 3728 17250908 SGTC_201 4262-0159 12.803 µM -0.751703659381541 0.201766452493629 no 2698 0.226114644638053 3751 1341029 SGTC_3201 9113999 49.47 µM -0.752176157827218 0.201618152730867 no 2699 0.225972564804601 3791 16649224 SGTC_2600 tangeritin 87.95 µM -0.752917017880387 0.201385755700259 no 2700 0.225749890537322 3714 68077 A bioactive flavone. SGTC_3312 9133330 71.43 µM -0.753666332249437 0.201150870062084 no 2701 0.225524801533477 3806 17617324 SGTC_415 dibenzyl ketone 100 µM -0.753947710206333 0.201062709687817 no 2702 0.2254403103019 3788 7593 SGTC_1432 4049-0298 68.4 µM -0.754138045061617 0.201003087768029 no 2703 0.225383167350207 3761 741646 SGTC_2479 5617353 43.85 µM -0.756342816185107 0.200313221975266 no 2704 0.224721841747681 3788 2731746 SGTC_2121 5257820 149.641 µM -0.756392991768695 0.200297538770035 no 2705 0.224706804297184 3835 791256 SGTC_1794 st048918 76.9 µM -0.756858021703651 0.200152221110602 no 2706 0.224567463576184 3679 672303 SGTC_2761 levamisole 97.89 µM -0.756924932107535 0.200131317428904 no 2707 0.224547418699746 3744 26879 An alkaline phosphatase inhibitor. SGTC_3033 9090887 49.47 µM -0.759775769444458 0.199241898209543 no 2708 0.223694314473247 3805 19325384 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.760357656404369 0.199060651033042 no 2709 0.2235204133364 3792 23847180 SGTC_497 capsazepine 133 µM -0.7607969782915 0.198923876113138 no 2710 0.223389169766628 3764 2733484 A calcium channel blocker. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.762581054613684 0.198369018539741 no 2711 0.222856643392123 3806 1377 SGTC_102 gallobenzophenone 83.616 µM -0.766142082037485 0.197264315542542 no 2712 0.221795882950182 3795 70837 SGTC_3126 9127922 49.47 µM -0.768176869596342 0.196634757323617 no 2713 0.22119105667769 3777 45595682 SGTC_1564 D-Arginine 115 µM -0.770477176716834 0.195924515639433 no 2714 0.220508444233976 3780 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2837 9008476 45.46 µM -0.772233946898427 0.195383145860874 no 2715 0.219987939495672 3777 2992805 SGTC_1871 st057448 67.3 µM -0.772266475750304 0.195373130281717 no 2716 0.219978308335263 3838 691747 SGTC_11 0438-0307 1.3 µM -0.772277097311339 0.195369859988365 no 2717 0.219975163550011 3770 4011476 SGTC_394 menadione 8.33 µM -0.772305670499195 0.195361062698317 no 2718 0.219966703853779 3733 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2195 6536160 144.242 µM -0.772322331282287 0.1953559331843 no 2719 0.219961771162938 3716 3834386 SGTC_2436 5633522 8.09 µM -0.772493198156407 0.195303331494468 no 2720 0.219911186960226 3754 5724242 SGTC_1196 1588-0294 184 µM -0.773211526559255 0.195082286888776 no 2721 0.21969860280784 3809 6144269 SGTC_1998 st075797 76.8 µM -0.773393924492217 0.19502618346654 no 2722 0.219644642234384 3747 24208315 SGTC_3027 9089541 49.47 µM -0.775943706599082 0.194242928373941 no 2723 0.218891112365258 3774 9943819 SGTC_642 0335-0876 158 µM -0.780434506085484 0.19286808822958 no 2724 0.217567581930632 3819 6812350 SGTC_2844 9010103 25.97 µM -0.782183744150836 0.192334178617909 no 2725 0.217053298248736 3854 2480525 SGTC_733 4069-0007 56.1 µM -0.782372457661252 0.192276632772755 no 2726 0.216997857658579 3815 5717425 YNL287W SEC21 SGTC_2627 acetyl isogambogic acid 100 µM -0.782452479388544 0.19225223431902 no 2727 0.216974351204616 3791 6857789 A caspase activator and apoptosis inducer. SGTC_2130 NSC 7 2.4545 µM -0.782750282266854 0.192161451496006 no 2728 0.216886884273644 3842 21448 SGTC_487 nimodipine 119 µM -0.787724939372106 0.190648847817203 no 2729 0.21542880724574 3682 4497 L-type voltage-gated calcium channels inhibitor SGTC_1172 0370-0043 85 µM -0.788346080892286 0.190460496920913 no 2730 0.215247150221892 3859 376585 SGTC_765 1319-0117 244 µM -0.788455493026611 0.190427331340374 no 2731 0.215215161117181 3772 3487746 YGL099W LSG1 SGTC_316 k060-0003 58.6 µM -0.788757515988795 0.190335798963434 no 2732 0.215126872216104 3787 6152314 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.78920929203519 0.190198932227924 no 2733 0.214994845982515 3834 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1629 st005085 44.9 µM -0.789828354925551 0.190011483734422 no 2734 0.214814008572216 3808 24207091 SGTC_3175 9106517 49.47 µM -0.78999684576128 0.189960485394765 no 2735 0.214764805214412 3850 41468073 SGTC_1928 4'-methoxychalcone 40.3 µM -0.790285623971752 0.189873098376678 no 2736 0.214680490294468 3874 641818 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.790446740248241 0.189824353811129 no 2737 0.214633457343805 3620 4000243 SGTC_2840 9008771 71.43 µM -0.790868467433234 0.189696799733429 no 2738 0.214510375397375 3785 2992978 SGTC_1622 st003707 19.4 µM -0.791360639305976 0.189548005891463 no 2739 0.214366785925962 3871 10140899 SGTC_2336 9001819 198.65 µM -0.792691897066017 0.189145898792615 no 2740 0.213978676202099 3837 2989602 SGTC_2050 5263056 171 µM -0.796881580924165 0.18788383439363 no 2741 0.212759904564935 3861 763468 YGL055W OLE1 SGTC_1949 st076024 69.1 µM -0.798713276999621 0.187333707451345 no 2742 0.212228343182091 3786 2921930 SGTC_254 nsc-64875 3.808 µM -0.799198593472351 0.187188115779528 no 2743 0.212087633697869 3870 56993 SGTC_2232 chlorophetanol 41.5365 µM -0.80557513535722 0.185281700976689 no 2744 0.21024393364758 3915 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3125 9127534 49.47 µM -0.805603489635721 0.185273250823038 no 2745 0.21023575642682 3681 1639235 SGTC_2991 9074669 71.4286 µM -0.80607962528045 0.185131388435486 no 2746 0.210098469383978 3807 17333109 SGTC_2412 st077135 33.4 µM -0.806175467271654 0.18510284092224 no 2747 0.210070841057538 3933 13258915 SGTC_3249 9135183 49.47 µM -0.806628313999397 0.184967992898925 no 2748 0.20994032801324 3838 4902779 SGTC_1033 k072-0102 21.3 µM -0.807482606517069 0.184713769191784 no 2749 0.209694245755791 3791 5965931 SGTC_1888 azatryptophan 97.5 µM -0.810250428846605 0.183891602811861 no 2750 0.208898129709438 3887 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_363 0455-0021 3.06 µM -0.810833122035746 0.183718807851981 no 2751 0.208730755302163 3846 4597466 SGTC_1785 bathophenanthroline 24 µM -0.810877945530326 0.183705519844117 no 2752 0.208717883351806 3787 72812 An iron chelator. SGTC_1089 terbinafine 2.25 µM -0.811688173212079 0.183465429594654 no 2753 0.208485291164034 3851 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1108 betulinic acid 729.144 nM -0.812096113027427 0.18334462113018 no 2754 0.208368241691157 3854 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1895 st058434 18.3 µM -0.812577892673891 0.183202009422385 no 2755 0.208230055414623 3863 5393175 SGTC_3323 9138564 53.9225 µM -0.813451701231016 0.182943529735706 no 2756 0.207979563602101 3853 43912313 YNL103W MET4 SGTC_2684 capsaicin 100 µM -0.814106488508197 0.182749987567497 no 2757 0.207791974551658 3870 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3190 9110366 49.47 µM -0.814619366211534 0.182598480370798 no 2758 0.207645110785525 3816 17123768 SGTC_376 3970-0862 59.1 µM -0.815280294911747 0.182403353717749 no 2759 0.207455942727661 3882 3135186 SGTC_2834 9001755 58.44 µM -0.815544306870766 0.182325445623511 no 2760 0.207380406886798 3805 2989575 SGTC_1963 st076565 50.3 µM -0.81599452626612 0.182192636979132 no 2761 0.207251633186492 3870 4914280 SGTC_916 4466-0038 42 nM -0.817267364442481 0.18181749412156 no 2762 0.206887826420352 3944 5722064 YGL116W CDC20 SGTC_1793 st048256 72.231 µM -0.81787835493644 0.18163758900677 no 2763 0.206713325472741 3730 672022 SGTC_3143 9086658 49.47 µM -0.820412510819976 0.180892600850729 no 2764 0.205990492891279 3947 25236626 SGTC_3183 9108214 49.47 µM -0.820624452517129 0.180830381379643 no 2765 0.20593010748848 3811 4974831 SGTC_660 4031-1742 102 µM -0.821851634943278 0.180470382658949 no 2766 0.20558067108027 3791 6738706 SGTC_804 1595-0054 20.9 µM -0.822254617570049 0.180352264267098 no 2767 0.205465999841068 3817 761523 Stimulates phospholipase C. SGTC_2492 derrusnin 100 µM -0.824094463966044 0.179813602687268 no 2768 0.204942942746405 3779 1715307 Part of coumarin class of compounds. SGTC_3235 9132602 49.47 µM -0.825580961975059 0.179379131701852 no 2769 0.20452091919814 3870 4912240 SGTC_71 0417-1750 47.813 µM -0.826522440804257 0.179104299644131 no 2770 0.204253896782128 3810 6811472 SGTC_1485 3909-9022 254 µM -0.827511462151357 0.178815874663766 no 2771 0.203973614050137 3910 714516 SGTC_995 3931-2021 34.6 µM -0.828479188618612 0.178533943005353 no 2772 0.203699588103601 3873 730143 SGTC_1901 st060216 58.6 µM -0.830182016810111 0.178038531377554 no 2773 0.203217940567063 3865 688792 SGTC_2036 5160441 105 µM -0.831050711899123 0.177786132123565 no 2774 0.202972490907708 3858 134534 YIL048W NEO1 SGTC_1519 esterone 74 µM -0.832363165442485 0.177405227271208 no 2775 0.202601993359549 3865 698 A steroid. SGTC_1497 4476-2978 41.3 µM -0.83238641961052 0.177398483013852 no 2776 0.20259543249782 3909 1528379 SGTC_1347 1493-0251 600 nM -0.832553708423455 0.177349970082231 no 2777 0.202548237873236 3923 3986378 SGTC_1525 8-methoxypsoralen 92.5 µM -0.833098270057802 0.177192107913343 no 2778 0.202394654582705 3883 4114 Related to psoralen; DNA damaging agent. SGTC_2692 st077426 47.7 µM -0.833641171470823 0.17703481539791 no 2779 0.202241608868727 3882 25238571 SGTC_1134 3477-0009 42.5 µM -0.833938454139211 0.176948722347004 no 2780 0.202157833237256 3970 3973534 SGTC_1231 0242-0792 125 µM -0.836037784135402 0.17634150976232 no 2781 0.201566823581651 3876 3707635 SGTC_1731 st035964 63 µM -0.836732624007191 0.176140824233692 no 2782 0.201371438424636 3877 6739575 SGTC_19 0279-0214 38.434 µM -0.83699853099813 0.176064062521604 no 2783 0.201296696882438 3931 3566274 YBR002C RER2 SGTC_558 k064-0027 21.3 µM -0.837779364179961 0.175838774960801 no 2784 0.201077315241498 3919 5088526 SGTC_377 3970-0964 33.1 µM -0.838476402523646 0.175637818373745 no 2785 0.200881597660263 3866 16481235 SGTC_2390 9097792 176.6 µM -0.838564283316856 0.175612492620782 no 2786 0.200856930210344 3907 4497149 SGTC_193 1273-0060 1.558 µM -0.838570565659959 0.175610682244762 no 2787 0.200855166875488 3742 2847393 YHR072W ERG7 SGTC_1449 4112-4002 201 µM -0.838605177048831 0.175600708530314 no 2788 0.200845452280003 3938 2059539 SGTC_2445 5742597 35.57 µM -0.839977092270732 0.175205662736537 no 2789 0.200460615362358 3842 1774255 SGTC_1091 telmisartan 47.6 µM -0.842039709077545 0.174612789646519 no 2790 0.199882863426336 3943 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3159 9100096 49.47 µM -0.842810578536187 0.174391540383107 no 2791 0.199667195371375 3852 25236875 SGTC_2220 6782180 200 µM -0.844171855650646 0.174001271816878 no 2792 0.199286689609267 3786 833803 SGTC_2334 9017922 200 µM -0.845452620155771 0.173634593049339 no 2793 0.198929087823579 3971 3163164 SGTC_515 4092-1064 102 µM -0.845767451697603 0.173544533125405 no 2794 0.198841243077511 3895 717353 SGTC_1114 scopoletin 1.73284 µM -0.845964998876283 0.173488038454227 no 2795 0.198786135123261 3885 5280460 A coumarin with genotoxic properties. SGTC_1137 ixabepilone 100 µM -0.848640049228786 0.172724178483821 no 2796 0.198040807353098 3858 154225 A novel microtubule stabilizer. SGTC_2610 ononetin 44.17 µM -0.848710620934982 0.172704055819394 no 2797 0.198021167401143 3902 259632 SGTC_1318 1280-3875 124 µM -0.849298365051702 0.172536525782351 no 2798 0.197857645190545 3926 373245 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.84950512460252 0.172477615881012 no 2799 0.197800139935708 3889 390807 SGTC_1170 0310-0127 64.8 µM -0.850170639305913 0.172288084639256 no 2800 0.19761511141481 3913 774975 SGTC_2949 9072542 2.23 µM -0.850710260937385 0.172134503947089 no 2801 0.197465160921452 3979 16457352 SGTC_761 k216-0224 480 µM -0.851970106068747 0.171776282054384 no 2802 0.19711534206226 3911 1340404 SGTC_526 4469-0568 170 µM -0.852516610895965 0.171621038118131 no 2803 0.196963711775666 3858 2901964 SGTC_2545 solidagenone 89.61 µM -0.854779583288292 0.170979156994958 no 2804 0.196336591519699 3709 6708572 An anti ulcer agent SGTC_1942 st076330 65.2 µM -0.854807868426726 0.170971143783198 no 2805 0.196328760741962 3904 24208414 SGTC_689 0833-0039 98 µM -0.855244108641256 0.170847586864383 no 2806 0.196208011044563 3875 5374726 SGTC_2464 5717415 7.67 µM -0.857734158476905 0.170143420850149 no 2807 0.195519636845827 3898 5285744 SGTC_1200 1643-0193 18.4 µM -0.857969731885143 0.170076899023893 no 2808 0.195454588611361 3891 5403974 SGTC_1695 st026914 34.495 µM -0.85854215622333 0.169915325836934 no 2809 0.195296581443727 3864 3289191 SGTC_2882 9058044 58.44 µM -0.86064999569328 0.169321213202821 no 2810 0.194715420653732 3911 18076804 SGTC_35 0133-0054 64.071 µM -0.861929373339792 0.168961260716421 no 2811 0.194363192012435 3934 99677 SGTC_3243 9134147 49.47 µM -0.86269127142312 0.168747134631537 no 2812 0.194153616374937 3966 24282180 SGTC_587 k089-0003 57 µM -0.862805875434945 0.168714941076923 no 2813 0.194122104113343 3820 9659696 SGTC_3268 9137683 49.47 µM -0.863133170383992 0.168623021983125 no 2814 0.194032126129528 3946 1953228 SGTC_1749 st037932 54.2 µM -0.866649946214787 0.167637385486648 no 2815 0.193066919188672 3989 594497 SGTC_3217 9129673 49.47 µM -0.869362368238564 0.166879722789144 no 2816 0.192324479754539 3934 17248312 SGTC_1021 4476-0760 85.3 µM -0.873820077925325 0.165639353753167 no 2817 0.191108122240338 3964 746768 SGTC_1337 1486-1011 40.3 µM -0.874632829706396 0.165413847734151 no 2818 0.190886859411728 3918 X1337 SGTC_3304 9125678 46.087 µM -0.875096075676351 0.165285404468338 no 2819 0.190760816083202 3878 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1451 4152-0210 104 µM -0.875934755616024 0.165053029634688 no 2820 0.190532751922996 3916 659563 SGTC_2370 9071495 200 µM -0.87631213163673 0.164948538290153 no 2821 0.190430185828619 3956 21791103 SGTC_563 tetrahydrosecaminediol 614 µM -0.877483918974743 0.16462435610948 no 2822 0.190111924802907 4001 334274 A psychoactive constituent of the cannabis plant. SGTC_2546 rhodinyl acetate 100 µM -0.879954093290261 0.163942320609056 no 2823 0.189442089501606 3844 6708682 SGTC_1233 0325-0408 14.2 µM -0.880194688801118 0.163875988329958 no 2824 0.189376925112224 3993 12874 SGTC_1190 1486-1332 13 µM -0.881567810747624 0.163497751459087 no 2825 0.18900528431814 3934 4150046 SGTC_1813 st051246 8.6015 µM -0.882880074557182 0.163136808671999 no 2826 0.188650535163861 3862 5291959 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.883329680763043 0.163013262100198 no 2827 0.188529085917022 4011 688664 SGTC_2196 6573537 42.6665 µM -0.883364940934262 0.163003575586712 no 2828 0.188519563351845 3966 2903087 SGTC_2243 6634756 200 µM -0.885712738461178 0.16235944131613 no 2829 0.187886171112005 4030 885676 SGTC_1568 digitonin 820 nM -0.885898063665718 0.162308666730129 no 2830 0.187836229827453 3923 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2608 thymoquinone 42.66 µM -0.886091372416996 0.162255715862337 no 2831 0.187784145879296 3944 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3341 9147222 25.867 µM -0.886626436674702 0.162109210448239 no 2832 0.187640027900987 3963 1939759 SGTC_774 k060-0086 136 µM -0.88663849008311 0.162105911108914 no 2833 0.187636782138227 3911 5911235 SGTC_1875 nocodazole 6 µM -0.886794110335956 0.162063317622635 no 2834 0.187594879561127 3935 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2385 9074692 200 µM -0.889385116193788 0.161355226671296 no 2835 0.186898070612098 3980 17046906 SGTC_4 0960-0234 25.671 µM -0.889628597363495 0.161288790048441 no 2836 0.186832672731584 3948 6821112 SGTC_1765 st044815 90.4 µM -0.889756885596487 0.161253792314781 no 2837 0.186798220821806 3996 645695 SGTC_2705 st078069 42.8 µM -0.889821826993164 0.161236077834269 no 2838 0.186780782255793 4015 1530061 SGTC_759 3486-0358 89.3 µM -0.890795054970169 0.160970756284333 no 2839 0.186519564269176 3914 875103 SGTC_1608 st001473 40.5 µM -0.891570305646327 0.160759611360373 no 2840 0.186311646095407 3936 7292267 SGTC_1641 st009299 47.1 µM -0.891854197543703 0.160682336681953 no 2841 0.186235543709324 3877 4046054 SGTC_1142 3253-1408 9.78 µM -0.892545684836488 0.160494217056246 no 2842 0.186050258581546 3910 256655 SGTC_3095 9117207 49.47 µM -0.893304300916686 0.160288000579006 no 2843 0.185847117693781 3936 17015229 SGTC_2213 7173844 200 µM -0.894375713015551 0.159997051123159 no 2844 0.185560451269769 3920 892728 SGTC_2342 7990637 118.86 µM -0.897026265498071 0.15927876002226 no 2845 0.184852450869489 4038 2033102 YER133W GLC7 SGTC_3161 9100388 49.47 µM -0.899044732691567 0.158733180600474 no 2846 0.184314417145403 4029 25236368 SGTC_1769 st044406 64.4 µM -0.900116152367344 0.15844408070924 no 2847 0.184029220530517 3960 670903 SGTC_1840 st055363 71 µM -0.900364581729769 0.158377096668303 no 2848 0.183963131442097 4017 676033 SGTC_2193 5925765 200 µM -0.901250961230742 0.158138253463022 no 2849 0.183727450410548 3957 877370 SGTC_1934 st074720 32.6 µM -0.904184437877897 0.157349487623783 no 2850 0.182948805320286 3924 17250992 SGTC_1841 st054148 70 µM -0.906478820725209 0.156734369592411 no 2851 0.182341234999917 4012 675442 SGTC_710 3448-4187 58 µM -0.906987557040806 0.156598193370412 no 2852 0.182206688647774 3950 3946412 SGTC_1997 st073024 93.8 µM -0.907713630410293 0.156403976304373 no 2853 0.182014770305182 3986 686268 SGTC_1581 himbacine 57.9 µM -0.908196980734312 0.156274773114246 no 2854 0.181887079501439 3970 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1578 josamycin 24.2 µM -0.908710024498265 0.156137709585989 no 2855 0.181751605637853 3986 5282165 A P450 substrate. SGTC_2099 5377090 177.372 µM -0.91024288969167 0.155728665059182 no 2856 0.181347214862813 4008 2243829 SGTC_1076 itraconazole 331 nM -0.910663266324247 0.155616611288385 no 2857 0.18123641227657 3976 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1751 st044839 27.194 µM -0.913520548432317 0.154856396054853 no 2858 0.180484415734234 3949 5291326 SGTC_2872 9044037 25.97 µM -0.913742663346837 0.154797402572418 no 2859 0.180426040309511 3979 6465195 SGTC_1263 0774-1208 64.8 µM -0.914305423273861 0.15464800061217 no 2860 0.180278190847346 4017 906585 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.915662918067444 0.154288004076511 no 2861 0.179921859996881 3971 2346 DNA damaging agent; causes G2/M arrest. SGTC_541 4513-1321 94 µM -0.920167842320524 0.153097308915752 no 2862 0.178742528101206 3985 747515 SGTC_697 0508-1955 564 µM -0.921883029403802 0.152645573502796 no 2863 0.178294796046391 3996 6243113 SGTC_3038 9091290 49.47 µM -0.92338015422558 0.152251993467891 no 2864 0.177904565117979 4000 25236843 SGTC_1889 st059080 5.18 µM -0.92719351186419 0.151252543640243 no 2865 0.176913035451872 3930 176925 Isolated from Daphnopsis sellowiana. SGTC_3221 9128209 49.47 µM -0.929179172338932 0.150733850028477 no 2866 0.17639811966232 4040 16460723 SGTC_994 3910-0338 138 µM -0.930132588311429 0.150485220362399 no 2867 0.176151219826949 4100 3479481 SGTC_244 nsc-207895 1.295 µM -0.933692642679165 0.149559253179517 no 2868 0.175231230626402 3805 42640 SGTC_864 0469-0573 172 µM -0.936400959274866 0.148857374142884 no 2869 0.174533392122074 3981 689425 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.937277127079892 0.148630781162105 no 2870 0.174308012678584 4037 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_48 0382-0018 55 µM -0.937982782743171 0.148448453461615 no 2871 0.17412662912177 4032 762596 SGTC_3354 9151612 71.43 µM -0.941433378856351 0.147559041220514 no 2872 0.17324140748406 4052 27261949 SGTC_1011 4112-3381 17.4 µM -0.946515301252094 0.146255657331317 no 2873 0.171942910815358 4100 2877139 SGTC_1510 1123-0200 71.5 µM -0.948432725003981 0.145765901850751 no 2874 0.17145460312682 4103 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_145 3737-0113 38.366 µM -0.949457226773033 0.145504672191652 no 2875 0.171194058313829 3990 6849351 SGTC_832 4083-0019 164 µM -0.950387396759409 0.145267768305188 no 2876 0.170957722764456 4097 1990758 SGTC_753 1322-0200 289 µM -0.952152764100372 0.144818863011074 no 2877 0.170509756402628 4120 5403907 SGTC_2556 citropten 84.59 µM -0.952394659434407 0.144757425657948 no 2878 0.170448433463483 4067 2775 A potential DNA crosslinker. SGTC_2465 5809242 33.21 µM -0.953144799386963 0.144567014338227 no 2879 0.170258355147138 4061 2731748 SGTC_2363 9053361 176 µM -0.953578912878875 0.144456898519013 no 2880 0.170148416984077 4106 6469797 YMR079W SEC14 SGTC_1836 st055642 81 µM -0.953726312786856 0.144419522393421 no 2881 0.170111098671156 4047 8571 SGTC_2173 5763948 167 µM -0.955098976116018 0.144071769733839 no 2882 0.169763823356494 4021 2867177 SGTC_624 k048-0052 28 µM -0.955804715740254 0.143893196531294 no 2883 0.169585452701742 4016 6835531 SGTC_2306 7482397 179.52 µM -0.956075371699008 0.143824752116893 no 2884 0.169517078247943 4051 891448 SGTC_1227 3909-8010 46.6 µM -0.957418166932606 0.143485506251631 no 2885 0.169178116255083 4023 15982272 SGTC_1498 4478-3555 97.6 µM -0.96217873990536 0.142287142805435 no 2886 0.167979913308031 3980 3437919 SGTC_1462 k081-0014 26.5 µM -0.962582911400918 0.142185714822337 no 2887 0.167878438322377 3651 3270634 SGTC_775 4577-0580 57.3 µM -0.966862272747233 0.141114798712642 no 2888 0.166806444441615 4122 2006902 SGTC_2046 4110841 106 µM -0.96828130797114 0.140760893860845 no 2889 0.166451948684734 4055 44119630 YMR134W ERG29 SGTC_199 4063-0024 41.6 µM -0.968331397995248 0.140748412512609 no 2890 0.166439444357804 4078 306215 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.969881003852154 0.140362655290299 no 2891 0.166052904905714 4089 368090 SGTC_3238 9133470 49.47 µM -0.970012688298939 0.140329907034455 no 2892 0.166020083808031 4061 3534688 SGTC_3259 9138485 49.47 µM -0.970337025760229 0.140249270540711 no 2893 0.165939263654373 4056 17646153 SGTC_2561 acetosyringone 100 µM -0.971142818277334 0.140049071355985 no 2894 0.165738582018034 4049 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3184 9108758 49.47 µM -0.971499517916067 0.139960511347052 no 2895 0.165649796536512 4063 902885 SGTC_1445 4239-0156 97.7 µM -0.971857843620971 0.139871585949467 no 2896 0.165560637286195 4154 4008346 SGTC_1384 3089-0840 101 µM -0.9720103846365 0.13983374162629 no 2897 0.165522691175265 4051 1069836 SGTC_1701 st028638 40.4 µM -0.974300216558363 0.13926648725953 no 2898 0.164953748585126 4068 3490878 SGTC_175 3793-3120 23.7 µM -0.974349110076622 0.139254392088214 no 2899 0.164941614092484 4071 5322297 SGTC_969 1313-0238 134 µM -0.977103287411596 0.138574223770103 no 2900 0.164259010217553 4083 5212874 SGTC_338 4055-0136 114 µM -0.97764937618818 0.138439631692129 no 2901 0.164123883798692 4004 2900563 SGTC_2019 4016004 108 µM -0.979172234920561 0.138064770197781 no 2902 0.163747442469516 4097 45595336 SGTC_701 4424-0219 185 µM -0.980819641025407 0.137660030695363 no 2903 0.163340845391273 4113 2911779 SGTC_1271 0832-2808 169 µM -0.98216443850563 0.137330237843958 no 2904 0.16300942194212 4111 3663794 SGTC_1736 st036774 51 µM -0.983772914361879 0.136936490685275 no 2905 0.162613589858449 4134 1272247 SGTC_992 3909-8734 162 µM -0.984300824948212 0.136807429038526 no 2906 0.162483812012505 4086 4288319 SGTC_675 1309-0189 238 µM -0.988308920345582 0.135830256905506 no 2907 0.161500689010124 4099 4246530 SGTC_2482 5981709 142.65 µM -0.989069928664838 0.135645264621416 no 2908 0.161314464615925 4031 877755 SGTC_2966 9084041 48.03 µM -0.990200708719074 0.135370704016976 no 2909 0.161038013109837 3972 17741380 SGTC_1623 st003709 20.3 µM -0.990628467952207 0.135266940715426 no 2910 0.160933515788687 4042 16192618 SGTC_2251 lansoprazole 556 µM -0.991168927283032 0.135135917273607 no 2911 0.160801550259926 4008 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1358 1509-0022 2.48 µM -0.995673929906824 0.134047156381485 no 2912 0.159704300465988 4105 3258434 SGTC_2523 spermine 47.74 µM -0.99855188741662 0.133354780120901 no 2913 0.159005908492295 4095 1103 A DNA binding polyamine. SGTC_808 0711-0032 135 µM -0.998734137078822 0.133311017655612 no 2914 0.15896174956761 4005 4252555 SGTC_50 0929-0078 56.389 µM -0.999747072813831 0.133067967843306 no 2915 0.15871646264564 3950 1377751 SGTC_1713 st033146 12.748 µM -1.00041158982524 0.132908685467033 no 2916 0.158555681738907 4089 674619 SGTC_2160 5660466 132.927 µM -1.00089610155062 0.132792632502762 no 2917 0.158438520741 3974 2859134 SGTC_2263 7948595 193.29 µM -1.0013702618492 0.13267912655352 no 2918 0.158323917843191 4068 2971371 SGTC_1735 st034310 56.75 µM -1.00234174463827 0.132446778790654 no 2919 0.158089283739743 4158 871153 SGTC_2081 5214970 32.255 µM -1.00428015233999 0.131984011625262 no 2920 0.157621798777967 4046 2063512 SGTC_1258 0671-0043 57.1 µM -1.00507290398828 0.131795075156754 no 2921 0.157430873144903 4115 4298767 SGTC_709 3807-1509 243 µM -1.00584388493443 0.131611506362204 no 2922 0.157245336606409 4150 1886677 YPL242C IQG1 SGTC_245 methotrexate 289.6 µM -1.00769494396425 0.13117149412357 no 2923 0.15680046649965 4072 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_764 1951-2361 146 µM -1.00874077601884 0.13092334079675 no 2924 0.156549485330499 4088 5438930 SGTC_112 phenothiazine 287.218 µM -1.00885888835495 0.130895335695302 no 2925 0.156521157093283 4023 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1192 1488-0095 21.4 µM -1.00922017216543 0.130809698964022 no 2926 0.15643452720311 4152 915875 SGTC_219 mitoxanthrone 164.414 µM -1.01334479109589 0.12983476625045 no 2927 0.1554477500143 4048 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3286 9117135 37.221 µM -1.0148987932861 0.129468756228334 no 2928 0.155077036744808 4080 3438150 SGTC_3269 9137823 49.47 µM -1.01560282239109 0.12930317364535 no 2929 0.154909280154152 4010 17682936 SGTC_1299 1079-1439 3.74 µM -1.01593376704934 0.129225388576256 no 2930 0.154830463839164 4066 323161 SGTC_1881 5652484 16 µM -1.01756071528176 0.128843463180402 no 2931 0.154443382332181 4095 2255129 SGTC_797 k781-0471 270 µM -1.01886141379428 0.128538688508191 no 2932 0.154134382325079 4081 23738129 SGTC_695 3505-6186 243 µM -1.01941288295269 0.12840962153982 no 2933 0.154003496272412 4120 1819379 SGTC_3032 9089427 49.47 µM -1.0250874920332 0.127086749456763 no 2934 0.152660953401201 4132 17173707 SGTC_337 1315-0038 354 µM -1.02605173028148 0.126862911062251 no 2935 0.152433600517371 4075 1626437 SGTC_134 0269-0018 6.916 µM -1.02708413823947 0.126623552157146 no 2936 0.152190423466261 4094 4378915 SGTC_168 3970-0862 530.542 µM -1.02814565489149 0.126377772686896 no 2937 0.151940658772451 4091 3135186 SGTC_1763 st044482 94.5 µM -1.03252821901306 0.125366570777639 no 2938 0.150912367584951 4120 88505 SGTC_1124 fisetin 1.16336 µM -1.03263863300174 0.125341167783074 no 2939 0.150886520856452 4150 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_360 0957-0399 1.01 µM -1.03297577674622 0.125263623213032 no 2940 0.150807617364344 4146 6752301 YPR165W RHO1 SGTC_485 niflumic acid 177 µM -1.038267486328 0.124050893602187 no 2941 0.149572770660955 4186 4488 A COX2 inhibitor. SGTC_1522 st012842 45.6 µM -1.0402619636433 0.123595947223074 no 2942 0.149109105250747 3975 3491067 YOR116C RPO31 SGTC_3292 9120825 59.784 µM -1.04123087092412 0.123375358702506 no 2943 0.148884205704949 4148 24824900 SGTC_1148 3909-7663 27.7 µM -1.04226907252392 0.123139300401411 no 2944 0.148643473475862 4166 4084526 SGTC_693 4161-2696 114 µM -1.04382662354399 0.122785750423191 no 2945 0.148282805761062 4159 805759 SGTC_524 r073-0010 27.8 µM -1.04480510909004 0.122564007499681 no 2946 0.148056526552858 4073 2772106 SGTC_1988 st071872 53.4 µM -1.04916853574516 0.12157859487953 no 2947 0.147050278596609 4164 16414116 SGTC_1275 0867-0008 21.1 µM -1.04962446563315 0.121475952381858 no 2948 0.146945402040427 4112 3422836 SGTC_1409 3909-8004 61.9 µM -1.05030632322125 0.12132256097755 no 2949 0.14678864946258 4154 2119279 SGTC_91 0417-1751 58.384 µM -1.05269152374281 0.120787055466817 no 2950 0.146241197359606 4265 6795624 SGTC_188 3229-0966 278.469 µM -1.05334238572516 0.12064121867784 no 2951 0.146092049713871 4189 5722370 SGTC_3262 9137218 49.47 µM -1.05423254270109 0.120441964521462 no 2952 0.145888232152807 4031 17650664 SGTC_2512 diallyl trisulfide 49.23 µM -1.05500138952285 0.120270051267013 no 2953 0.145712344623075 4173 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_516 3992-2719 87.3 µM -1.0552095275044 0.120223541605337 no 2954 0.145664753848296 4066 5350887 YDR037W KRS1 SGTC_1974 st069448 26.9 µM -1.05534723024241 0.120192778081077 no 2955 0.145633273845013 4134 6323587 YNR016C ACC1 SGTC_2159 5658611 73.75 µM -1.05602905236881 0.120040537115002 no 2956 0.145477470974866 4141 793844 SGTC_1441 4106-0040 13 µM -1.05657964646445 0.119917696688227 no 2957 0.145351736807161 4138 2904180 SGTC_1569 carminic acid 40.6 µM -1.05692528487763 0.119840628238232 no 2958 0.145272843865817 4240 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_787 4152-0075 138 µM -1.05753659036351 0.119704408396729 no 2959 0.145133382215966 4167 9566539 SGTC_440 fluspirilene 35.1 µM -1.05794848139527 0.119612686535508 no 2960 0.145039465286743 4235 3396 An atypical antipsychotic. SGTC_3289 9119912 71.43 µM -1.05826843777791 0.119541471338722 no 2961 0.144966538983001 4202 17014829 SGTC_1048 3161-0300 24.5 µM -1.05916170958563 0.119342807176603 no 2962 0.144763069999569 4142 2165101 SGTC_2651 TUB2.036 5 µM -1.05977101552172 0.119207430917956 no 2963 0.144624393000451 4122 15992207 YFL037W TUB2 SGTC_946 3434-1334 87.4 µM -1.06173075494179 0.118772748968889 no 2964 0.144178966584693 4141 4047976 SGTC_1371 2421-0008 32.7 µM -1.06313354366003 0.118462290388827 no 2965 0.143860697272727 4131 2827552 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.06549789964106 0.117940321177678 no 2966 0.143325337779379 4147 688662 SGTC_3088 9117578 49.47 µM -1.06678073179668 0.117657797432725 no 2967 0.143035430690012 4198 678341 SGTC_2138 5575593 77.673 µM -1.07073625867259 0.11678967125265 no 2968 0.14214401729444 4154 762213 SGTC_371 0195-0006 7.36 µM -1.07329354669001 0.116230841406408 no 2969 0.141569714864255 3990 3928593 SGTC_859 0439-0102 54.6 µM -1.07442554430445 0.11598407912652 no 2970 0.141315999388585 4166 610143 SGTC_60 0986-0278 202 µM -1.07443564565802 0.115981878824744 no 2971 0.141313736752944 4116 3110598 SGTC_2944 9067346 25.62 µM -1.07456443184806 0.115953828896147 no 2972 0.141284891660055 4121 6473075 SGTC_1308 1187-1617 41.4 µM -1.07481499803201 0.115899268806319 no 2973 0.141228782135937 4181 2882570 SGTC_471 1-acyl-paf 4 µM -1.07661591284291 0.115507660906715 no 2974 0.140825946083838 4095 16759367 SGTC_1602 st001878 87.6 µM -1.07902757244611 0.114984720718239 no 2975 0.140287718185653 4171 595405 YLR310C CDC25 SGTC_669 0108-0021 26.2 µM -1.07905490919869 0.114978802729994 no 2976 0.140281625259127 4066 17201 SGTC_851 0394-0702 453 µM -1.08034299205225 0.114700198058189 no 2977 0.139994735852666 4171 762646 SGTC_1552 6-methylflavone 10.6 µM -1.08057770054536 0.114649483787944 no 2978 0.139942503166195 4090 689013 SGTC_2171 5739187 198.077 µM -1.08064746133751 0.114634413410628 no 2979 0.139926980957357 4111 2262761 SGTC_1594 piperine 70.1 µM -1.08299741945217 0.114127576887111 no 2980 0.139404784227946 4147 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2435 5706476 10.6 µM -1.08479399465344 0.113741171467509 no 2981 0.139006452954675 4160 5725375 SGTC_2804 7954240 19.48 µM -1.08607476000658 0.113466275797433 no 2982 0.138722959029327 4209 828705 SGTC_1503 4585-0012 61.3 µM -1.08627238609822 0.113423900766736 no 2983 0.13867925012809 4230 2922052 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.0899591986927 0.11263544201373 no 2984 0.13786555875108 4197 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1411 3909-8223 150 µM -1.09091580392892 0.112431504300252 no 2985 0.137654966183617 4214 X1411 SGTC_657 3534-0529 86.7 µM -1.09216264861376 0.112166086921926 no 2986 0.137380808363931 4233 1049549 SGTC_803 4488-1585 147 µM -1.09243878248698 0.112107366585509 no 2987 0.137320142155999 4174 747204 SGTC_358 0075-0058 9.45 µM -1.09562503738787 0.111431393326856 no 2988 0.13662145007336 3998 1069125 SGTC_2602 kawain 100 µM -1.09623581051538 0.111302149915409 no 2989 0.136487795949247 4188 5369129 SGTC_214 4373-3496 70 µM -1.09708276437016 0.111123106814393 no 2990 0.136302606955976 4263 3779166 SGTC_964 1287-0107 19.4 µM -1.09729238297813 0.111078826025783 no 2991 0.136256799773188 4204 51516812 YPR165W RHO1 SGTC_656 4090-1979 187 µM -1.09767310618124 0.110998432645193 no 2992 0.136173628676592 4247 22330961 SGTC_2866 9034245 58.44 µM -1.10152790782147 0.110186800421568 no 2993 0.135333482590902 4165 6462273 SGTC_306 1672-3436 11.6 µM -1.10212201307911 0.110062090548506 no 2994 0.135204315240534 4231 6797378 SGTC_2461 5755302 26.15 µM -1.10456315922068 0.10955072739775 no 2995 0.134674460959281 4235 2788904 SGTC_1809 st050081 57.6 µM -1.1075994375435 0.10891708150247 no 2996 0.134017423231081 4283 5036894 SGTC_2566 crystal violet carbinol 226 nM -1.10931996316279 0.108559193846384 no 2997 0.133646088031696 4245 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2990 9074105 71.4286 µM -1.11177343082837 0.10805031084881 no 2998 0.133117789133417 4114 6502001 SGTC_3072 9116419 49.47 µM -1.11248597978493 0.107902840724265 no 2999 0.132964627490734 4246 17170162 SGTC_2639 lactacystin 53 µM -1.11273317443817 0.107851714855293 no 3000 0.132911521617566 4259 3870 A proteasome inhibitor. SGTC_640 3381-0960 37.1 µM -1.11409061835095 0.107571273379845 no 3001 0.132620156495964 4270 1745025 SGTC_1140 3229-1848 2.98 µM -1.11846579980217 0.106670958723299 no 3002 0.131684052651252 4236 2849525 SGTC_1075 aripiprazole 15.2 µM -1.11905404310963 0.106550327364556 no 3003 0.131558542048383 4275 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2339 9000433 200 µM -1.12313394764786 0.105716368704338 no 3004 0.130690305115701 4240 2988954 SGTC_2518 prenyletin 46.28 µM -1.12387303060306 0.105565801638955 no 3005 0.130533447012454 4190 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3043 9092303 49.47 µM -1.12652752032785 0.105026303874067 no 3006 0.129971149306175 4216 25236084 SGTC_638 3970-0837 4.09 µM -1.12765351020951 0.104798061820412 no 3007 0.129733139282556 4198 4118451 YLR208W SEC13 SGTC_1312 1218-2183 165 µM -1.12785228796303 0.10475780620909 no 3008 0.129691153311051 4268 6744073 SGTC_3127 9126946 49.47 µM -1.12988698373475 0.104346392240097 no 3009 0.129261924654656 4211 27243249 SGTC_1219 1469-0211 33.1 µM -1.13364055083878 0.10359049867768 no 3010 0.128472677980267 4261 6822282 SGTC_2177 5811945 192 µM -1.13512090547308 0.103293479959336 no 3011 0.128162331723766 4273 5343475 SGTC_2914 7968218 45.32 µM -1.13574429556305 0.103168588002408 no 3012 0.128031798165289 4191 2977111 SGTC_2544 sphondin 68.51 µM -1.13587327144908 0.103142762259238 no 3013 0.128004803044787 4216 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_186 3455-3465 67.277 µM -1.13742373086445 0.102832670324563 no 3014 0.127680595736538 4219 755278 SGTC_819 1013-0258 27.7 µM -1.13995805534699 0.102327264874924 no 3015 0.127151888169671 4231 5753198 SGTC_2076 5212012 200 µM -1.14321065681105 0.101681267958301 no 3016 0.126475569354426 4191 604802 SGTC_651 3253-0966 34.4 µM -1.14408237672178 0.101508641894818 no 3017 0.126294737798465 4251 781462 SGTC_926 2268-1401 59.4 µM -1.14737598521136 0.100858337780212 no 3018 0.125613130980654 4210 2931578 SGTC_2225 6654152 15.4 µM -1.14808759006803 0.100718235418283 no 3019 0.125466203354555 4135 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1597 7-benzyloxygramine 47.5 µM -1.14883899425506 0.100570451398589 no 3020 0.125311188458944 4161 260807 SGTC_109 0132-0036 33.701 µM -1.15146664048603 0.100054897369065 no 3021 0.124770155844094 4046 67274 A color developer. SGTC_1165 k072-0275 30.3 µM -1.1528388419106 0.0997864345568833 no 3022 0.124488269168274 4219 6153523 YGL055W OLE1 SGTC_850 0388-0143 75.9 µM -1.15547379020925 0.0992723991209229 no 3023 0.123948229821291 4225 67273 SGTC_1284 0929-0043 16 µM -1.15730914872799 0.0989154963385108 no 3024 0.123573038525404 4254 1239883 SGTC_704 1310-0270 142 µM -1.1583004746632 0.0987231145590082 no 3025 0.123370718876854 4269 5718033 SGTC_1981 st071826 47 µM -1.15975992959193 0.098440383831641 no 3026 0.123073281322668 4285 11838600 SGTC_1111 tnp00062 510.699 nM -1.16304549507208 0.0978060632224867 no 3027 0.122405522175904 4292 676306 SGTC_3345 9148410 3.559 µM -1.1639068130521 0.0976402715001388 no 3028 0.122230889137619 4200 4903596 SGTC_1910 st062352 60.4 µM -1.16752887080134 0.0969453309697751 no 3029 0.121498428060951 4150 2245730 SGTC_884 0851-0618 334 µM -1.16898584831247 0.0966668166980365 no 3030 0.121204666552908 4270 9642473 SGTC_2458 5808907 16.39 µM -1.16931636925645 0.0966037165304498 no 3031 0.12113809520065 4402 2731747 SGTC_612 0302-0167 22.4 µM -1.16990862480168 0.0964907239746375 no 3032 0.121018871331209 4259 235821 SGTC_1862 st057513 3.81 µM -1.17179388952736 0.096131693206172 no 3033 0.120639908277557 4246 5393163 SGTC_3144 9087057 49.47 µM -1.17225343585668 0.0960443260399895 no 3034 0.12054766019482 4172 17249618 SGTC_1094 duloxetine 25.4 µM -1.17265725708925 0.0959676013187591 no 3035 0.12046663922677 4276 60834 A selective serotonin reuptake inhibitor. SGTC_1666 st014829 29 µM -1.17356740081946 0.0957948422614694 no 3036 0.120284172517043 4256 3858230 SGTC_976 1348-1067 47.6 µM -1.17358905794528 0.0957907341996257 no 3037 0.120279833043339 4264 5310671 YGL099W LSG1 SGTC_3229 9132204 49.47 µM -1.17847483108305 0.0948672787539481 no 3038 0.11930368027394 4324 17682924 SGTC_1929 genistein trimethyl ether 50.5 µM -1.18124057265422 0.0943474447014033 no 3039 0.118753583854596 4240 136420 SGTC_1178 0988-0033 191 µM -1.1840167707861 0.0938277609355045 no 3040 0.118203212082329 4323 5392207 SGTC_2094 5332512 191.667 µM -1.1849743137276 0.0936490069407501 no 3041 0.118013801471047 4299 755774 SGTC_274 sirtinol 40.1 µM -1.18516995408199 0.0936125157806281 no 3042 0.117975128476804 4327 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2347 9049783 174.81 µM -1.18680941105138 0.093307134147028 no 3043 0.117651402923701 4302 6467988 YPL169C MEX67 SGTC_213 1246-0773 967 nM -1.18872955201582 0.0929504060641342 no 3044 0.117273053851628 4290 6251622 SGTC_2483 5729050 27.16 µM -1.18874522133282 0.0929474991366104 no 3045 0.117269969881872 4296 2865180 SGTC_1206 3978-0017 132 µM -1.18893118521517 0.0929130047731432 no 3046 0.117233373630832 4345 3873677 SGTC_538 2922-0838 53.3 µM -1.19268005263388 0.0922196460826365 no 3047 0.116497350348217 4300 777039 SGTC_70 0141-0289 43.283 µM -1.19299520898459 0.0921615324274408 no 3048 0.116435624700489 4235 352408 SGTC_1725 st036284 20.55 µM -1.19397660194703 0.0919807408831955 no 3049 0.116243560415576 4334 707914 SGTC_1747 st037496 66.6 µM -1.20035245784959 0.0908125764597602 no 3050 0.115001242295562 4256 723305 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.20113925305645 0.0906691888001532 no 3051 0.114848594364127 4275 803109 SGTC_1704 st028805 70.8 µM -1.20336446972888 0.0902645691146889 no 3052 0.114417655445341 4336 2876101 SGTC_829 1635-0120 117 µM -1.20368272801112 0.0902068087843684 no 3053 0.114356115270956 4293 285054 SGTC_3031 9088762 49.47 µM -1.20399854604878 0.0901495184754718 no 3054 0.114295070255731 4253 205253 SGTC_1555 citronellol 128 µM -1.20778015180368 0.0894656224877666 no 3055 0.113565919012075 4256 8842 A terpine precursor. SGTC_3018 9082602 49.47 µM -1.21411209853298 0.0883291541481738 no 3056 0.112352460307067 4228 17332089 SGTC_1255 0566-0045 221 µM -1.21433264022152 0.0882897657435961 no 3057 0.112310363149284 4314 2788469 SGTC_1459 k035-0031 35.7 µM -1.21440551690009 0.0882767529594309 no 3058 0.112296454873887 4027 3877128 YMR208W ERG12 SGTC_326 k292-0812 17.5 µM -1.21774152470599 0.0876826081451672 no 3059 0.111661105915822 4283 3579357 SGTC_771 0250-0039 27.3 µM -1.21816246863258 0.0876078502864044 no 3060 0.111581119439768 4257 3005115 SGTC_1508 1080-0625 72.9 µM -1.21842616351289 0.0875610434266679 no 3061 0.111531033835528 4196 767111 SGTC_1668 st014914 51.6 µM -1.22421974865118 0.0865373634331412 no 3062 0.110434670583797 4310 2839556 SGTC_2659 sanguinarine 24.21 µM -1.23038701253781 0.085457516523584 no 3063 0.109276107217394 4254 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2406 ethylparaben 405.7 µM -1.23097079433368 0.0853558254130474 no 3064 0.10916689384996 4304 8434 A possible steroid mimic. SGTC_2623 humulene 100 µM -1.23302859295469 0.0849980927346659 no 3065 0.108782548308546 4310 6187145 An anti-inflammatory. SGTC_553 k007-0256 45.7 µM -1.23327100357012 0.0849560255880674 no 3066 0.1087373361836 4359 6287000 SGTC_3108 9121785 49.47 µM -1.23508634107171 0.084641493775642 no 3067 0.108399186137034 4135 17140271 SGTC_1799 st045822 46.1415 µM -1.24081540637231 0.0836545831031315 no 3068 0.107336974264969 4305 3674992 SGTC_2278 7948257 134.34 µM -1.24128913119287 0.0835733660768238 no 3069 0.107249479172066 4317 1247028 SGTC_1272 0839-0021 27 µM -1.24142290212824 0.0835504426548752 no 3070 0.107224781524796 4321 5027250 SGTC_385 1494-0393 12.4 µM -1.24369446542677 0.0831619011930771 no 3071 0.106806016863893 4294 3090647 SGTC_1714 st033236 13.627 µM -1.24474226150948 0.0829831385912831 no 3072 0.106613252970008 4358 2916566 SGTC_1501 4491-0275 38.4 µM -1.2451421963238 0.0829149827022142 no 3073 0.106539742895615 4307 5104718 SGTC_2919 7978188 46.38 µM -1.24534080497031 0.0828811519669391 no 3074 0.106503251205805 4337 2980291 SGTC_1994 st072947 40.9 µM -1.24564721308829 0.0828289791822628 no 3075 0.106446970501982 4373 5286565 YDL195W SEC31 SGTC_780 0109-0199 192 µM -1.24935268547925 0.0821999951955654 no 3076 0.105768052909736 4378 610414 SGTC_2226 7298446 200 µM -1.25040020610475 0.0820228381355512 no 3077 0.105576694670493 4330 3283010 SGTC_620 0109-0052 432 µM -1.25078632160734 0.0819576107550036 no 3078 0.105506223318769 4360 493037 SGTC_2118 5526350 200 µM -1.25292437851751 0.0815971311608489 no 3079 0.105116614434246 4368 743594 SGTC_727 3032-0951 202 µM -1.25430897391673 0.0813643248911607 no 3080 0.104864861705055 4372 3652836 SGTC_564 3555-0129 330 µM -1.25506643227461 0.0812371778255125 no 3081 0.104727322441819 4220 563260 SGTC_1609 st001574 46.4 µM -1.2625679385342 0.079986056883628 no 3082 0.103372248097615 4335 3960012 SGTC_1205 4161-2785 76 µM -1.26333708565856 0.0798586045276291 no 3083 0.103234031883525 4358 3498106 SGTC_2864 9034755 47.6 µM -1.2647524256942 0.0796244755176689 no 3084 0.102980045150466 4268 4930451 SGTC_1373 2887-0003 58.5 µM -1.26847594772618 0.0790110020586867 no 3085 0.102314017391997 4287 776948 SGTC_101 0490-5701 117.494 µM -1.26927460760307 0.0788798853708784 no 3086 0.102171569762907 4199 4661669 SGTC_3180 9109287 49.47 µM -1.27017684897278 0.0787319619825123 no 3087 0.102010821130869 4383 18891271 SGTC_580 1123-0028 41 µM -1.27420413104052 0.0780742472581335 no 3088 0.10129554077936 4399 1677248 YPR107C YTH1 SGTC_673 1082-0474 110 µM -1.2750638582146 0.0779343825304962 no 3089 0.101143320195971 4354 3098046 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.27599170503609 0.0777836491665767 no 3090 0.100979225679042 4400 4620898 SGTC_3315 9136395 68.55 µM -1.27665408208724 0.0776761781388845 no 3091 0.100862199651059 4329 16876844 SGTC_2645 abamectin 100 µM -1.27678293487467 0.077655284809345 no 3092 0.100839445969428 4296 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2747 doxorubicin 7.63 µM -1.2789874784083 0.0772984812607602 no 3093 0.100450732672292 4370 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2722 naftopidil 47.16 µM -1.28298352815391 0.0766549005836596 no 3094 0.0997489234864985 4287 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1085 doxorubicin 7.67 µM -1.2850979746033 0.0763160128151105 no 3095 0.0993790246352666 4370 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3117 9124945 49.47 µM -1.28741518948612 0.0759459374483331 no 3096 0.0989748064164372 4261 17592065 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.29044563711125 0.0754640179427222 no 3097 0.0984479876812613 4259 4330530 SGTC_2307 7538926 6.34 µM -1.29091057119777 0.0753902880641405 no 3098 0.0983673446708876 4322 96582 SGTC_2444 5485484 36.41 µM -1.29935179164414 0.0740611965570909 no 3099 0.0969116139472879 4427 6790631 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.29989255843546 0.0739766654739093 no 3100 0.0968188979811249 4295 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2543 pimpinellin 60.67 µM -1.30022716337389 0.0739243979395133 no 3101 0.0967615616658897 4206 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_226 1,3-diallylurea 8.28947 mM -1.30330333593655 0.0734452006013965 no 3102 0.0962356113315866 4302 74537 YKL182W FAS1 SGTC_1977 st070720 65.3 µM -1.30584849915042 0.0730505212770975 no 3103 0.0958020416383338 4398 682188 SGTC_3166 9102297 49.47 µM -1.30905479965727 0.0725556320128015 no 3104 0.0952578943698564 4371 25237072 SGTC_1229 0139-0193 12.2 µM -1.31067296935163 0.0723068462111141 no 3105 0.0949841373790135 4445 3090752 SGTC_2348 9022543 33.42 µM -1.31557553018383 0.0715570909254 no 3106 0.0941582755264009 4392 3162678 YDL140C RPO21 SGTC_2084 5306078 60.6385 µM -1.31581765567474 0.0715202175081265 no 3107 0.0941176259321053 4318 679340 SGTC_1456 k015-0012 13 µM -1.32014789863014 0.0708632220477728 no 3108 0.0933928216436559 4400 2989616 SGTC_1781 st038725 66.3 µM -1.32025441368564 0.0708471199371178 no 3109 0.0933750450565189 4372 4270275 YIL048W NEO1 SGTC_1993 st073995 70.8 µM -1.32123448334503 0.0706990925888839 no 3110 0.0932115958632362 4370 3098394 SGTC_2223 6903751 107.57 µM -1.32147819721604 0.0706623195613768 no 3111 0.093170983803634 4341 5598863 SGTC_3137 9097352 49.47 µM -1.32320989454731 0.0704014537101268 no 3112 0.0928827932242254 4395 44120435 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.32440653983611 0.0702216220713249 no 3113 0.0926840318974691 4411 688664 SGTC_3232 9132874 49.47 µM -1.32442523775797 0.070218814956887 no 3114 0.0926809286934548 4347 3784940 SGTC_1705 st027868 56.3335 µM -1.328196666956 0.0696543735852675 no 3115 0.0920565726102772 4319 292948 SGTC_2791 5663188 71.43 µM -1.32866391763546 0.0695846875751395 no 3116 0.0919794370919247 4398 54690634 SGTC_682 0kpi-0099 17 µM -1.32993330554596 0.0693956414062172 no 3117 0.0917701233629663 4401 1714895 YML126C ERG13 SGTC_3109 9122853 49.47 µM -1.33195590543906 0.0690952392430882 no 3118 0.0914373392848986 4423 1234709 SGTC_1001 4048-4355 44.4 µM -1.33403054676636 0.0687881498739288 no 3119 0.0910969228423607 4380 21824233 SGTC_3058 9093861 49.47 µM -1.33649377321315 0.0684249096422783 no 3120 0.0906939672029068 4404 17217477 SGTC_1863 st057641 20.1 µM -1.33982365633517 0.0679362224016127 no 3121 0.0901513414055883 4422 3921635 SGTC_971 1315-0384 26.7 µM -1.33997684299289 0.0679138060346346 no 3122 0.0901264368114255 4426 6769120 SGTC_2504 purpurogallin 52.29 µM -1.34423582743522 0.0672928574274738 no 3123 0.0894360697826831 4302 5281571 An antioxidant. SGTC_958 1222-0007 33 µM -1.34821444593269 0.0667167591684051 no 3124 0.0887947098158121 4457 7312461 SGTC_1276 0871-0068 94.2 µM -1.34937540858028 0.0665493748006334 no 3125 0.0886082077261814 4427 3414906 SGTC_1387 3342-1166 1.8 µM -1.35202218281261 0.0661689857079898 no 3126 0.0881841095416292 4380 3418228 SGTC_2043 5101342 149 µM -1.35637468215287 0.0655471179516774 no 3127 0.0874899922545464 4429 678451 SGTC_422 cantharidin 155 µM -1.35646441537543 0.0655343450719163 no 3128 0.0874757250210311 4316 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_933 2914-0560 114 µM -1.3578024841023 0.0653441094966516 no 3129 0.0872631832509492 4408 463887 SGTC_956 1185-0240 191 µM -1.36289898471913 0.0646234520232625 no 3130 0.0864571743735009 4387 1416193 SGTC_2589 lobaric acid 100 µM -1.36631365490981 0.0641440734323169 no 3131 0.0859202684595902 4359 73157 A novel microtubule depolymerizer. SGTC_2957 9076800 11.52 µM -1.36913857170087 0.0637495824028554 no 3132 0.085477981640122 4391 16459615 SGTC_3007 9078383 71.4286 µM -1.37410572400612 0.0630605146416594 no 3133 0.0847044313434655 4423 6496995 SGTC_875 0709-0210 25.7 µM -1.37772504978336 0.0625620878217604 no 3134 0.0841440971294629 4397 6251364 SGTC_872 0588-0139 234 µM -1.37957035627956 0.0623091506322674 no 3135 0.083859484939877 4391 2047100 SGTC_2327 6189656 200 µM -1.38614972487011 0.0614137997349835 no 3136 0.0828505947061944 4496 5349088 SGTC_1418 3966-3099 2.4 µM -1.38923507557844 0.0609974073793499 no 3137 0.0823806395175669 4417 740335 SGTC_1037 k284-1091 78.7 µM -1.39037944665852 0.0608435277813106 no 3138 0.0822068421795875 4394 3334711 SGTC_3086 9117350 49.47 µM -1.39096591609673 0.0607647850041298 no 3139 0.0821178812940501 4394 2679265 SGTC_2930 9013230 14.89 µM -1.39149176193285 0.060694249687417 no 3140 0.0820381780156764 4411 2995857 SGTC_1490 4089-0339 670 nM -1.39507434254056 0.0602153966019268 no 3141 0.0814967111914177 4400 742542 SGTC_3191 9110352 49.47 µM -1.3952046560424 0.0601980346085207 no 3142 0.0814770666903332 4393 17122424 SGTC_3272 9137413 49.47 µM -1.3976832712185 0.0598685481160549 no 3143 0.0811040999958694 4358 17614870 SGTC_2079 5212404 121 µM -1.40103612638936 0.0594250972545345 no 3144 0.0806016351475281 4386 758462 SGTC_2107 5363541 170.161 µM -1.40736142630753 0.0585955239023664 no 3145 0.0796601216206061 4382 244052 SGTC_72 0744-0168 198.391 µM -1.4076178545207 0.0585620856704902 no 3146 0.0796221288201412 4325 677577 SGTC_2888 9058547 12.99 µM -1.40862426657636 0.0584309943318094 no 3147 0.0794731497372883 4367 16476514 SGTC_1702 st027038 51 µM -1.41199331947942 0.0579938309379437 no 3148 0.0789759641184827 4465 5521182 SGTC_607 4491-0986 66.8 µM -1.4121220852148 0.0579771736241774 no 3149 0.0789570084552404 4442 698981 YDR232W HEM1 SGTC_335 4077-0256 27.6 µM -1.41277383364268 0.0578929202221165 no 3150 0.0788611171314843 4377 3121989 SGTC_2982 9019404 25.97 µM -1.41343465395791 0.057807592365026 no 3151 0.0787639811713349 4383 22333232 SGTC_2252 omeprazole 400 µM -1.42030770063243 0.0569259673355987 no 3152 0.077759060136152 4474 4594 A proton pump inhibitor. SGTC_3041 9091929 49.47 µM -1.42238400055151 0.0566617271577157 no 3153 0.0774574026143507 4439 25236887 SGTC_303 1348-1668 34.2 µM -1.42327983550772 0.0565480175951446 no 3154 0.0773275250280599 4450 5380509 SGTC_107 0358-0022 2.6945 µM -1.42430180332322 0.0564185174672602 no 3155 0.0771795628568204 4475 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2783 7738165 71.43 µM -1.42485422910909 0.056348613422783 no 3156 0.0770996713685047 4434 17201110 SGTC_131 0141-0277 33.849 µM -1.42538210650834 0.0562818795418712 no 3157 0.0770233887855983 4413 1547771 SGTC_2491 paeonol 100 µM -1.42586651059374 0.0562206963608508 no 3158 0.0769534389334163 4419 11092 Increases levels of cortical cytochrome oxidase. SGTC_677 0929-0063 136 µM -1.42699832865064 0.0560779452652177 no 3159 0.076790188190838 4470 1539583 SGTC_2563 tomatine 8.54 µM -1.42732294752373 0.0560370553476508 no 3160 0.076743414563582 4408 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1346 1488-2224 62.4 µM -1.43096527555627 0.0555798678378855 no 3161 0.076220083683024 4476 3722427 SGTC_2807 7945238 51.95 µM -1.43469930810553 0.0551142311078329 no 3162 0.0756864007355278 4432 17148797 SGTC_499 genistein 192 µM -1.4359137691255 0.0549634528351777 no 3163 0.0755134399744072 4548 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1071 trifluoperazine 6.31 µM -1.44008170626616 0.0544484710736035 no 3164 0.0749221420486934 4507 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2032 5185112 25.99 µM -1.44066129562462 0.0543771614527562 no 3165 0.0748401972116744 4341 5718189 SGTC_2880 9042983 58.44 µM -1.44143910038468 0.0542815805761703 no 3166 0.0747303353032753 4406 6464714 SGTC_447 ml7 120 µM -1.4479243903577 0.0534897988173373 no 3167 0.0738190987659471 4521 4216 Selective myosin light chain kinase inhibitor. SGTC_726 3448-4391 34.2 µM -1.45480782932327 0.0526594475199845 no 3168 0.0728612350446544 4551 1356692 SGTC_3069 9117009 49.47 µM -1.45592822461078 0.0525252670523667 no 3169 0.072706231138807 4461 41904981 SGTC_154 3389-1638 511.116 µM -1.4561656064991 0.0524968726591375 no 3170 0.0726734223855723 4450 5238686 SGTC_2010 4012422 159 µM -1.45910138017918 0.0521467168284178 no 3171 0.0722686032159809 4420 952393 SGTC_1369 1866-0067 208 µM -1.46037713028382 0.0519951348409726 no 3172 0.0720932272934376 4489 3531355 SGTC_899 1083-0020 478 µM -1.46113041292501 0.0519057958680027 no 3173 0.0719898276810022 4515 767123 SGTC_570 0987-0065 62.6 µM -1.46301521288252 0.0516827938614897 no 3174 0.0717316081416038 4321 3104428 SGTC_225 nsc-122657 1.016 µM -1.4647102280253 0.0514828975180793 no 3175 0.0714999966124278 4486 275685 SGTC_2086 5274770 176.623 µM -1.46649147742802 0.0512734944748276 no 3176 0.0712572206634125 4517 689278 SGTC_1041 0206-0046 107 µM -1.47018959512208 0.0508409090531804 no 3177 0.0707552059654092 4477 50494 SGTC_2922 7999257 32.47 µM -1.47173830610884 0.0506606148395997 no 3178 0.0705457795677997 4445 2988377 SGTC_3193 9111931 49.47 µM -1.47511428177229 0.0502693633323855 no 3179 0.0700909107121638 4478 17087244 SGTC_3186 9110464 49.47 µM -1.47867071859128 0.0498598064422908 no 3180 0.0696141709405566 4472 17018021 SGTC_2104 5389443 200 µM -1.48097359671579 0.0495960312267175 no 3181 0.0693068047319253 4502 2244536 SGTC_1853 st056710 91.2 µM -1.48262918748845 0.0494070862912115 no 3182 0.0690864789876657 4515 269167 SGTC_2218 6965428 192.983 µM -1.48341276272491 0.0493178610297886 no 3183 0.0689823892931749 4399 675684 SGTC_2082 5219693 150 µM -1.4841349005807 0.0492357455698585 no 3184 0.0688865679779068 4435 2834649 SGTC_1907 st060210 83.7 µM -1.4879860593008 0.0487996662041428 no 3185 0.0683772850631626 4478 688793 SGTC_2516 gossypol 71.55 µM -1.49186976651855 0.0483630327980648 no 3186 0.0678666449382557 4508 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_34 0469-0683 81.75 µM -1.49510119254803 0.048002119906989 no 3187 0.0674440173533311 4464 3690923 SGTC_1692 fluoroquinolonic acid 71 µM -1.49714835122867 0.0477745935771178 no 3188 0.0671773305048865 4506 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_621 3584-0052 32.1 µM -1.4984772334476 0.0476273610699949 no 3189 0.0670046516725258 4522 2273927 SGTC_2431 5490079 200 µM -1.49857428827829 0.0476166222090689 no 3190 0.0669920535496724 4528 5722345 SGTC_2852 9023854 51.95 µM -1.50753668536277 0.046633286016598 no 3191 0.0658365739382412 4498 19798528 SGTC_1202 1988-0068 29.6 µM -1.51327328686337 0.0460124767880067 no 3192 0.0651051276041335 4473 2850480 SGTC_2780 5215298 71.43 µM -1.51402423796721 0.0459317033586386 no 3193 0.0650098460962517 4512 2834131 SGTC_340 k038-0059 454 µM -1.51759711207987 0.0455489589156606 no 3194 0.0645579976714577 4487 23733424 SGTC_2273 7815444 169.05 µM -1.51772937978356 0.045534839101452 no 3195 0.0645413172021773 4444 2824616 SGTC_942 3253-1115 227 µM -1.51824225565171 0.0454801219629965 no 3196 0.0644766693518867 4527 46497897 SGTC_1109 tnp00067 928.257 nM -1.51923008816045 0.0453748821721201 no 3197 0.064352295135158 4504 676295 SGTC_3325 9138760 55.175 µM -1.52282522763458 0.0449935227483437 no 3198 0.0639012183085503 4449 43844959 SGTC_1230 0170-0365 3.77 µM -1.53059651294043 0.04417798773874 no 3199 0.0629345720418576 4532 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2148 5546263 113.568 µM -1.53453435173165 0.0437693149728881 no 3200 0.0624491244876116 4534 792097 SGTC_1821 st053465 65.6 µM -1.53581917194578 0.0436366368937638 no 3201 0.0622913681317345 4535 675086 SGTC_386 1509-0011 3.07 µM -1.53784601760578 0.0434279929319518 no 3202 0.062043134469455 4517 3107280 SGTC_1351 1496-0003 46.5 µM -1.53867543092959 0.0433428454768521 no 3203 0.0619417766431879 4536 3891978 SGTC_1788 fluconazole 20 µM -1.53906433888315 0.0433029666877893 no 3204 0.0618942949653709 4518 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1136 pergolide 1.05886 µM -1.54103585305299 0.043101262344418 no 3205 0.0616540301576605 4454 47811 A dopamine receptor agonist. SGTC_1837 st055472 66.5 µM -1.54125087025021 0.0430793100487295 no 3206 0.0616278705101829 4558 676091 SGTC_2803 7707263 71.43 µM -1.54132206916794 0.0430720429480594 no 3207 0.0616192101432376 4479 2199229 SGTC_3029 9088683 49.47 µM -1.5416229252027 0.0430413462360324 no 3208 0.0615826256450945 4525 25236615 SGTC_905 2-aminofluorene 215 µM -1.54626263288455 0.0425701853438287 no 3209 0.0610205762716625 4530 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3228 9131799 49.47 µM -1.54935146475987 0.042258834257123 no 3210 0.0606486271943388 4543 17015818 SGTC_2149 5554786 194.827 µM -1.55828267542535 0.0413689316142544 no 3211 0.0595831269707677 4557 745063 YPR165W RHO1 SGTC_295 k015-0027 31 µM -1.56068825242714 0.0411318549151704 no 3212 0.0592986621971532 4585 3887424 SGTC_902 1120-0002 2.07 µM -1.56145312066986 0.0410567061363796 no 3213 0.0592084383074232 4507 3280475 SGTC_184 1494-0393 24.714 µM -1.5630103494695 0.0409040515542492 no 3214 0.059025080270857 4511 3090647 SGTC_2294 7971431 200 µM -1.56413777074968 0.040793818452007 no 3215 0.0588926087250805 4519 5741572 SGTC_159 3970-0959 50 µM -1.56452119894664 0.040756383907259 no 3216 0.058847609265541 4544 6615653 SGTC_2022 5136654 200 µM -1.56597432139142 0.0406147667803836 no 3217 0.0586773144320773 4527 1713771 SGTC_2481 5478948 45.16 µM -1.57298399275248 0.039937224835363 no 3218 0.0578612623754746 4526 77792 SGTC_305 1682-2595 20.8 µM -1.57494827796376 0.0397490172455208 no 3219 0.0576341918385322 4540 226033 SGTC_833 3852-0053 558 µM -1.57715962858296 0.0395380006659181 no 3220 0.057379399848963 4583 3123681 SGTC_1382 3002-2117 298 µM -1.57953427890462 0.0393124168239943 no 3221 0.0571067801618047 4581 1497314 SGTC_3067 9117431 49.47 µM -1.58222913502972 0.0390576843407773 no 3222 0.0567986357536366 4541 17150885 SGTC_1768 st044301 37.178 µM -1.58948814801736 0.0383782023478111 no 3223 0.0559751138693888 4552 3931349 SGTC_1356 1502-0781 85.8 µM -1.58988860137252 0.0383410000362608 no 3224 0.0559299587253356 4550 567702 SGTC_2816 7982706 58.44 µM -1.59091657824235 0.0382456350775346 no 3225 0.0558141755480295 4516 2981853 SGTC_2606 farnesol 9.78 µM -1.5929783217579 0.0380549510241391 no 3226 0.0555825271567191 4529 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1243 0416-0003 5.65 µM -1.59979926530615 0.0374296239679046 no 3227 0.0548215609351743 4524 2141977 SGTC_2985 9022375 71.43 µM -1.60200818949593 0.0372289235307663 no 3228 0.0545768992703181 4561 4939335 SGTC_2849 9019321 12.99 µM -1.60383693105284 0.0370634321573494 no 3229 0.0543750008595665 4539 16489627 SGTC_3155 9099265 49.47 µM -1.60402162373197 0.0370467519344192 no 3230 0.0543546431404967 4518 25236499 SGTC_2819 7996655 46.38 µM -1.60737659915082 0.0367448193128591 no 3231 0.0539858901153492 4527 6456960 SGTC_1996 st072960 66.8 µM -1.61428593542366 0.0361293495650253 no 3232 0.053232709686707 4576 1719405 SGTC_2878 9043973 25.97 µM -1.61612745042312 0.0359667435854478 no 3233 0.0530333801846206 4563 6465167 SGTC_2075 5212009 200 µM -1.61657629126992 0.0359272018821098 no 3234 0.0529848865202166 4491 780898 SGTC_1896 st058441 89 µM -1.6168012763527 0.0359073946887035 no 3235 0.0529605919164226 4565 688759 SGTC_1144 3486-0183 12.5 µM -1.61948877291788 0.0356714843305406 no 3236 0.052671070089959 4562 6744069 SGTC_2760 etidronate 98.04 µM -1.62159706483758 0.0354873074254136 no 3237 0.0524448257707255 4514 3305 A chelator and antioxidant. SGTC_883 0850-0245 24.6 µM -1.62635586007882 0.0350744521706598 no 3238 0.0519369874904241 4596 6823229 YPR165W RHO1 SGTC_3119 9125183 49.47 µM -1.62779376660172 0.0349504830026007 no 3239 0.0517843113550172 4445 22695334 SGTC_2143 5623677 140.463 µM -1.62788568635359 0.034942570383201 no 3240 0.0517745635092462 4531 5375313 SGTC_3234 9132280 49.47 µM -1.62928001205319 0.0348227245063047 no 3241 0.0516268777511707 4575 17612295 SGTC_2968 9090663 33.37 µM -1.63402229454671 0.0344176365133597 no 3242 0.0511270846980873 4502 25236811 SGTC_433 pimozide 108 µM -1.64320339289669 0.0336443872440706 no 3243 0.0501704290698423 4495 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1 0258-0098 57.368 µM -1.64528232453555 0.0334712956505728 no 3244 0.049955801586464 4490 6790032 YDR047W HEM12 SGTC_2671 danthron 100 µM -1.65160115040735 0.032949686573109 no 3245 0.0493079426817189 4558 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1086 cerivastatin 2.18 µM -1.65193622288817 0.0329222149671614 no 3246 0.0492737764272039 4584 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1948 st076329 66.6 µM -1.66701167031673 0.0317056190011228 no 3247 0.0477560421627205 4502 24208413 SGTC_2906 7926292 26.41 µM -1.66743199584768 0.0316722381278463 no 3248 0.0477142680579568 4565 2966319 SGTC_196 k015-0023 18.111 µM -1.66907422848198 0.0315420956814237 no 3249 0.0475513350045052 4533 5211998 SGTC_3094 9117742 49.47 µM -1.68698805938854 0.0301509731120782 no 3250 0.0458028239915592 4543 17149698 SGTC_2848 9016370 25.97 µM -1.688816615987 0.0300118799370756 no 3251 0.0456272892880393 4559 7894410 SGTC_24 0417-1663 219 µM -1.69495022615736 0.029549193924448 no 3252 0.0450424316748014 4601 4329390 SGTC_1767 st044992 70.3 µM -1.69580452110103 0.0294852228342186 no 3253 0.0449614530032568 4608 9600693 SGTC_1649 st011737 51.3 µM -1.69649629567118 0.0294335058324663 no 3254 0.0448959655522142 4600 1761035 SGTC_1570 verbenone 133 µM -1.7031375526541 0.0289408278895841 no 3255 0.0442711648762669 4593 29025 A natural terpanoid with antifungal properties. SGTC_3240 9133527 49.47 µM -1.70951326890706 0.0284743166480818 no 3256 0.0436779579906179 4585 17617455 SGTC_222 nsc-310342 10.666 µM -1.7098701173572 0.0284483919988654 no 3257 0.0436449466942702 4612 432556 SGTC_387 norethindrone acetate 66.7 µM -1.71270107543189 0.0282434210895839 no 3258 0.0433837735983652 4597 541197 SGTC_2495 cafestol 54.53 µM -1.72103990400119 0.0276467935354145 no 3259 0.042621791550113 4593 16667697 An anti-infammatory. SGTC_2401 5128683 200 µM -1.73132055380431 0.0269257273399408 no 3260 0.041697303762455 4576 708373 SGTC_2649 anisomycin 9.56 µM -1.73293116464477 0.0268141970771148 no 3261 0.0415539521447979 4647 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_67 0335-0847 266 µM -1.73551375670936 0.0266361651626281 no 3262 0.0413249234952538 4591 4552207 YOR254C SEC63 SGTC_561 1550-0330 72.9 µM -1.73970889891929 0.0263490766447175 no 3263 0.0409550729832238 4573 6812934 SGTC_768 0384-0033 77.3 µM -1.74847125085076 0.0257577750203669 no 3264 0.040191229779451 4573 3965305 YMR134W ERG29 SGTC_37 0566-0070 1.56 µM -1.7495175917709 0.0256879138418977 no 3265 0.0401007953242104 4541 1626686 SGTC_3054 9094397 49.47 µM -1.79087838097847 0.0230507648050157 no 3266 0.0366564068255593 4597 2598354 SGTC_2572 astragaloside iv 100 µM -1.79696786918531 0.0226824591172694 no 3267 0.0361703604105127 4587 45006101 An anti-inflammatory agent. SGTC_745 0469-0705 296 µM -1.79786914057366 0.0226283719076168 no 3268 0.0360988737174302 4654 3486736 SGTC_973 1325-0077 65.9 µM -1.82732279338132 0.0209197018269768 no 3269 0.033825625046273 4642 2835149 SGTC_2135 5326629 150.42 µM -1.82813137061284 0.0208743784942484 no 3270 0.0337649189220463 4603 5020077 SGTC_1950 st077106 7.18 µM -1.8292065729717 0.0208142387537366 no 3271 0.0336843340742562 4555 13831864 SGTC_825 1988-2224 89.6 µM -1.8330989819842 0.0205977483593884 no 3272 0.0333939262477387 4631 1180859 SGTC_3264 9137442 49.47 µM -1.83745896419825 0.02035752007269 no 3273 0.0330710845364933 4596 17015726 SGTC_3105 9121040 49.47 µM -1.84952717876888 0.0197049305696877 no 3274 0.0321908635037998 4630 41448907 SGTC_3083 9117465 49.47 µM -1.8504743479793 0.0196544725578816 no 3275 0.032122605963891 4594 16420915 SGTC_2995 9067767 71.4286 µM -1.85370557437079 0.0194831619729645 no 3276 0.0318906468915432 4624 11673567 SGTC_948 3448-0295 75.3 µM -1.85659735199893 0.0193309251131307 no 3277 0.0316842304828149 4618 678569 SGTC_1516 st013856 110 µM -1.8652810048899 0.0188798380611885 no 3278 0.0310710131261052 4656 5281404 A mutagen and neurotoxin. SGTC_2797 7859098 81.82 µM -1.86659390599716 0.0188124226360434 no 3279 0.0309791596272088 4611 972681 SGTC_1414 3917-0015 5.4 µM -1.89090940248164 0.0176004008789219 no 3280 0.0293182195446483 4665 6618702 SGTC_1039 k821-0043 94 µM -1.89763814860103 0.0172770152072622 no 3281 0.0288718827221638 4630 15992768 SGTC_216 k038-0035 28.382 µM -1.90231367877132 0.0170553083785193 no 3282 0.0285650792310783 4620 4444231 YPR107C YTH1 SGTC_3016 9080866 49.47 µM -1.91911218630395 0.016278700697886 no 3283 0.0274850687734644 4648 17066299 SGTC_566 0958-0068 16.5 µM -1.92031259081877 0.0162243835898468 no 3284 0.0274092134660931 4581 6815365 SGTC_1390 3413-2614 145 µM -1.9226155608663 0.0161206110582038 no 3285 0.0272641741489744 4657 3421432 SGTC_1846 st056244 14.8 µM -1.92484573243957 0.0160206614377251 no 3286 0.0271243303572564 4674 5393182 SGTC_3100 9120536 49.47 µM -1.96632040130708 0.0142564219316386 no 3287 0.0246308058222099 4609 16421196 SGTC_1482 3346-2049 8.48 µM -1.97269413834464 0.0140007049238806 no 3288 0.0242652101011401 4698 3826804 SGTC_341 1486-1430 230 µM -1.98723525313553 0.0134320674588712 no 3289 0.0234481664557925 4654 2054753 YPL210C SRP72 SGTC_2759 disulfiram 3.38 µM -1.98831690567314 0.0133905772616761 no 3290 0.0233883261156519 4589 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_155 k072-0202 43.6 µM -1.99418705795958 0.0131673338623207 no 3291 0.0230658079855242 4670 5857737 SGTC_2322 7413319 38.22 µM -2.00220675491773 0.0128675453927746 no 3292 0.0226312497507578 4608 1840400 SGTC_403 arphamenine a 50 µM -2.00245831400522 0.01285823800926 no 3293 0.0226177310821807 4690 5487158 An arginine aminopeptidase inhibitor. SGTC_2349 9023730 187.07 µM -2.01750419134532 0.0123120453919438 no 3294 0.0218214620373197 4693 4126287 SGTC_843 0310-0051 143 µM -2.01853621241223 0.0122753289755805 no 3295 0.0217677233489967 4705 2065037 SGTC_2774 tamoxifen 10.92 µM -2.02346722394664 0.0121012040808817 no 3296 0.0215124997436466 4675 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_283 0987-0079 11.7 µM -2.03358372228842 0.0117506603623529 no 3297 0.0209967922038687 4699 411556 SGTC_2654 protoveratrine a 100 µM -2.03736712784523 0.0116218453816182 no 3298 0.0208066327288364 4722 5702278 A heart drug and vasodilator. SGTC_1989 st071868 50.2 µM -2.05002543253296 0.0111997358053664 no 3299 0.0201809745334315 4687 16414057 SGTC_2205 7238770 200 µM -2.08725870205707 0.0100344772536417 no 3300 0.018432377854509 4719 279867 SGTC_2754 granisetron 64.02 µM -2.08870884915825 0.00999131765665668 no 3301 0.0183669698975607 4673 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1314 1222-0010 41.1 µM -2.0939032721992 0.0098380470526194 no 3302 0.0181342988654168 4703 3526027 SGTC_593 1203-0218 61.7 µM -2.09660942271361 0.00975901388460352 no 3303 0.0180140822372402 4732 3666956 SGTC_930 2810-3379 265 µM -2.10058088415199 0.00964403168019615 no 3304 0.0178388867673525 4693 1015764 SGTC_871 0574-0004 149 µM -2.10069796817484 0.00964065989290611 no 3305 0.0178337439024903 4671 9551173 SGTC_2222 6885208 172.143 µM -2.12621540466782 0.00892994939026899 no 3306 0.0167426640068507 4741 609514 SGTC_324 1315-0088 19.6 µM -2.13699422559297 0.00864380453206588 no 3307 0.0162992306428833 4713 6787421 SGTC_2073 5212005 126 µM -2.1435009708412 0.0084749903312853 no 3308 0.0160364466064007 4683 691789 SGTC_3150 9097574 49.47 µM -2.14370121782573 0.00846984124084051 no 3309 0.0160284172837321 4722 17217476 SGTC_2469 5655019 90.81 µM -2.14965022063116 0.00831811759001129 no 3310 0.0157914463823791 4743 2788239 SGTC_156 3474-0145 5.642 µM -2.18578455874036 0.00744680787183199 no 3311 0.0144156854961429 4666 2265471 SGTC_2064 5220758 200 µM -2.19026758948106 0.00734452194189768 no 3312 0.014252417958714 4723 788518 SGTC_2950 9072895 21.46 µM -2.20111867232582 0.00710205122201082 no 3313 0.0138638118697173 4667 17332245 SGTC_3103 9120822 49.47 µM -2.23307882642431 0.00642843658417327 no 3314 0.0127718733134476 4721 17141819 SGTC_3 0833-0587 95.581 µM -2.25436457311012 0.0060117760020586 no 3315 0.012086621042076 4644 5382644 SGTC_735 3076-0345 636 µM -2.29311401951768 0.00531435055021911 no 3316 0.0109207207294868 4741 2888990 SGTC_2037 5169046 200 µM -2.29648461997633 0.00525722957879592 no 3317 0.0108240937771103 4751 5718022 SGTC_27 0485-0001 32.618 µM -2.3024757433205 0.00515704597854768 no 3318 0.0106541789088993 4766 2054479 SGTC_379 3970-0972 5.9 µM -2.30560120822021 0.00510545933260959 no 3319 0.0105664628591023 4743 2898042 YBL034C STU1 SGTC_893 0958-0369 48.9 µM -2.33601520974134 0.00462695605391766 no 3320 0.00974522442180176 4607 6819948 SGTC_2867 9039098 71.43 µM -2.34329797507079 0.00451849040497995 no 3321 0.00955705536617135 4727 6463460 SGTC_1029 k015-0030 64.7 µM -2.34782514276547 0.00445221496831656 no 3322 0.00944169191522168 4751 2208316 SGTC_3071 9117417 49.47 µM -2.35210063367814 0.00439042259708416 no 3323 0.00933386187009407 4728 45595590 YGL055W OLE1 SGTC_781 4335-2806 94.4 µM -2.38599833742033 0.00392701239223374 no 3324 0.0085164140319205 4754 845254 SGTC_2070 5230947 200 µM -2.38689751244728 0.00391534004750469 no 3325 0.0084956136264146 4777 2835538 SGTC_2319 6033012 152.6 µM -2.39671637987889 0.00378988784963633 no 3326 0.00827136143832225 4723 847246 SGTC_3012 9080433 71.4286 µM -2.40001929725979 0.00374850485988446 no 3327 0.00819710378153416 4748 17688859 SGTC_1758 st042942 75.2445 µM -2.41604833823385 0.00355337269953745 no 3328 0.00784498913602781 4738 669317 SGTC_817 1391-0715 46 µM -2.41999185450528 0.00350678560299227 no 3329 0.00776042738294753 4756 1353946 SGTC_932 2857-0803 154 µM -2.43585375489666 0.0033248905875014 no 3330 0.00742834485453597 4736 674898 SGTC_835 0312-0010 67.2 µM -2.45393622032444 0.0031279131352983 no 3331 0.00706510204234184 4773 1626196 SGTC_546 peri-Naphthalide 147 µM -2.46907774799044 0.00297112265418707 no 3332 0.00677308916516215 4749 223824 A penicillin ester. SGTC_1210 3013-0140 750 nM -2.47367647465711 0.0029249252245595 no 3333 0.00668653691437063 4765 905973 SGTC_2591 skatole 100 µM -2.48968666553966 0.00276909979611747 no 3334 0.0063927879373195 4725 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3148 9097893 49.47 µM -2.49986098092401 0.0026740083119366 no 3335 0.00621210251740221 4736 17174100 SGTC_2725 haloperidol 53.21 µM -2.50777127154716 0.00260212551209366 no 3336 0.00607476419219827 4746 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1053 3366-3204 134 µM -2.52235015374608 0.00247420216760963 no 3337 0.00582868023419769 4761 3632071 YPR165W RHO1 SGTC_2283 7944793 200 µM -2.54976916868979 0.00224891422913712 no 3338 0.00538971319684789 4748 2970533 SGTC_3236 9132701 49.47 µM -2.60718468123648 0.00183625929037414 no 3339 0.00456450539068609 4772 24282524 SGTC_1920 st075728 45.7 µM -2.62306425632188 0.00173497691089075 no 3340 0.00435714178624529 4755 3400306 SGTC_476 mead acid 10 µM -2.64266073845002 0.00161700648096324 no 3341 0.00411287054295284 4797 5312531 An omega 9 fatty acid. SGTC_2770 toltrazuril 17.5 µM -2.6548263700138 0.00154749567915218 no 3342 0.00396746196966042 4743 68591 Kills coccidiodes. SGTC_115 0527-0192 112.043 µM -2.66003018138838 0.0015186034452727 no 3343 0.00390668248072307 4747 4233931 SGTC_2768 sulfasalazine 50.2 µM -2.67485160109773 0.00143898859706855 no 3344 0.00373811676536063 4752 5384001 An antioxidant and salicylic acid derivative. SGTC_450 aminopyrene 156 nM -2.68358991838331 0.00139385411075228 no 3345 0.00364181928987412 4769 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_723 4182-0001 115 µM -2.79643339813202 0.000916312566988775 yes 3346 0.0025835029705029 4769 744821 YLR208W SEC13 SGTC_3004 9076122 71.4286 µM -2.81655458329421 0.000848958616351753 yes 3347 0.00242708969149146 4785 44782551 SGTC_310 1273-0058 1.06 µM -2.95862686430667 0.000488595260084017 yes 3348 0.00154506508949333 4493 2734232 SGTC_1040 k898-0338 155 µM -3.41171422542918 7.16495904829669e-05 yes 3349 0.000322778765573308 4795 20969351 SGTC_3308 9128332 17.569 µM -3.45551200080533 5.87565448692815e-05 yes 3350 0.000274624370258435 4784 17332805 YDL196W YDL196W SGTC_2769 toremifene 3.73 µM -3.59045570813876 3.14341009255327e-05 yes 3351 0.000165050161376331 4803 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2820 7989630 71.43 µM -3.92546106647137 6.05895133319134e-06 yes 3352 4.32818854860751e-05 4807 2984098 SGTC_2620 irigenin 100 µM -4.04556124829139 3.25025553838534e-06 yes 3353 2.60989578412791e-05 4792 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2873 9040596 71.43 µM -4.08292200010928 2.66839059014637e-06 yes 3354 2.22364765986406e-05 4805 6463863 SGTC_1939 st074455 53.6 µM -4.50283787459505 2.59053127497146e-07 yes 3355 3.35260173576943e-06 4806 1644229 SGTC_2828 7998861 71.43 µM -7.50165635927589 3.01909646101807e-17 yes 3356 3.15082001167264e-14 4810 2988188