SGTCid condition conc unit WSS1|YHR134W.score WSS1|YHR134W.strain.pval WSS1|YHR134W.strain.significant WSS1|YHR134W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2526 patulin 37.61 µM 9.90080497161993 4.22933388166678e-27 yes 1 2.06468891525239e-23 8 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2750 bromebric acid 70.15 µM 9.43199676646312 8.41757004832545e-25 yes 2 2.01177629107944e-21 1 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2592 piperlongumine 83.33 µM 7.3698136001134 5.69045647492385e-16 yes 3 8.54333867092514e-14 4 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_369 0957-0393 4.5 µM 6.37449394471296 1.86883298559886e-12 yes 4 9.17840341923534e-11 3 6997992
SGTC_46 0329-0187a 2.197 µM 5.86954409352403 7.42716901222985e-11 yes 5 2.18497562774114e-09 28 46494817
SGTC_2753 fluvastatin 17.09 µM 4.76077855111965 8.88069782346835e-08 yes 6 9.64237813555803e-07 17 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1987 st072290 61.9 µM 4.71085225057332 1.18319959597057e-07 yes 7 1.23341515592287e-06 6 54697379
SGTC_456 gingerol 170 µM 4.61212288902697 2.06988561938874e-07 yes 8 1.99288612009898e-06 8 442793 A herb.
SGTC_428 3448-4153 16.5 µM 4.56802206713053 2.64805353959975e-07 yes 9 2.46174104146956e-06 20 3834874
SGTC_450 aminopyrene 156 nM 4.42976321835617 5.6528054413864e-07 yes 10 4.71683039677714e-06 21 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_910 3454-3003 490 µM 4.42749245794999 5.72264114776785e-07 yes 11 4.76674524486319e-06 9 820824
SGTC_3246 9135460 32.98 µM 4.1172954898711 2.90289879170083e-06 yes 12 1.91672220351004e-05 3 41446951
SGTC_1491 4138-0063 26.5 µM 4.06814562143092 3.71837280233782e-06 yes 13 2.36943819313531e-05 9 23883227
SGTC_2532 xanthone 78.9 µM 4.05168831206354 4.03736114343551e-06 yes 14 2.54246879677688e-05 26 7020 An insecticide.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 3.97460810977751 5.91281202750122e-06 yes 15 3.52476177399007e-05 70 140250 A respiratory chain inhibitor.
SGTC_2271 7849410 118.62 µM 3.86560768192582 1.00294703118234e-05 yes 16 5.54064716961273e-05 13 972430
SGTC_2144 5628481 200 µM 3.78801932200332 1.44939244221195e-05 yes 17 7.59265212568328e-05 27 2818399
SGTC_1100 amiodarone 5.07 µM 3.78573038633738 1.46507552147613e-05 yes 18 7.66288849078126e-05 19 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_631 k072-0230 41.5 µM 3.70533168176461 2.13037988972634e-05 yes 19 0.000105557143693336 22 5773147
SGTC_2506 ethyl hematommate 54.16 µM 3.66515796512057 2.56185861127221e-05 yes 20 0.000123592982632653 22 3940691 An allergen.
SGTC_2261 9010538 184.68 µM 3.65493597585658 2.68419242087358e-05 yes 21 0.000128623083365028 23 6457250
SGTC_2435 5706476 10.6 µM 3.63171831119686 2.98293511058447e-05 yes 22 0.000140770171272346 32 5725375
SGTC_1178 0988-0033 191 µM 3.62853508787855 3.02626799700484e-05 yes 23 0.000142517007471408 39 5392207
SGTC_2309 7664088 163.95 µM 3.61353326651877 3.23863247123918e-05 yes 24 0.000151026290426119 52 704922
SGTC_763 3453-1109 128 µM 3.59275178991973 3.55621202092395e-05 yes 25 0.000163602115883154 31 1560353
SGTC_753 1322-0200 289 µM 3.57196746862395 3.90314638154413e-05 yes 26 0.000177154715564203 34 5403907
SGTC_153 4077-0274 519.67 µM 3.510346222123 5.12947486364454e-05 yes 27 0.00022376178877133 29 3121976
SGTC_2749 bexarotene 57.39 µM 3.47989510113363 5.86202269942487e-05 yes 28 0.000250805070637805 41 82146 An retinoic acid receptor inhibitor.
SGTC_715 0868-0130 184 µM 3.41705640508065 7.69662629465204e-05 yes 29 0.000316510813846012 17 2876258
SGTC_2206 7254556 146.969 µM 3.31673064731253 0.000117826222060192 yes 30 0.000455386881178206 9 4398905
SGTC_1530 rhein 70.4 µM 3.30907972379401 0.000121661000884754 yes 31 0.000468015897554662 43 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_263 alizarin 107.927 µM 3.21639470583949 0.000178430460971091 yes 32 0.000649060795952953 106 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2479 5617353 43.85 µM 3.2110063824106 0.00018239544813595 yes 33 0.000661354985065361 69 2731746
SGTC_3321 9137793 26.8275 µM 3.20820874154055 0.000184486431461033 yes 34 0.000667822590543242 105 4904192
SGTC_1730 st033808 45.1 µM 3.19173356691197 0.000197261742790885 yes 35 0.000707108590770405 78 1045166
SGTC_3150 9097574 49.47 µM 3.18356075053431 0.000203901560388606 yes 36 0.000727377914749132 26 17217476
SGTC_446 go6976 132 µM 3.10860881568392 0.000275307210801396 yes 37 0.000939852064209804 44 3501 A protein kinase C inhibitor.
SGTC_2101 5377231 179.231 µM 3.09700460296944 0.000288251059460833 yes 38 0.000977434191923035 27 2844213
SGTC_1189 1431-2119 7.28 µM 3.08236154339312 0.00030539340857301 yes 39 0.00102682620951405 75 3107275
SGTC_2524 avocatin b 10.57 µM 3.05941505578925 0.000334174708925026 yes 40 0.00110884833994225 52 6710748
SGTC_283 0987-0079 11.7 µM 3.02747183823975 0.000378454475828764 yes 41 0.00123304345716579 75 411556
SGTC_1425 4048-4433 7.33 µM 2.99889598614562 0.000422623322012747 yes 42 0.0013547989642488 88 23734946
SGTC_1334 1486-0610 236 µM 2.96075612885739 0.00048904075176428 yes 43 0.00153442415856949 64 3742339
SGTC_1253 0550-0034 176 µM 2.94373773620909 0.000521689860693315 yes 44 0.00162137331672002 66 5969915
SGTC_1949 st076024 69.1 µM 2.90603868088255 0.000601321943469227 yes 45 0.001830180984459 82 2921930
SGTC_729 4092-0585 94.1 µM 2.89939969474418 0.000616457768636579 yes 46 0.00186938974885627 67 2169061
SGTC_2520 obtusaquinone 4.71 µM 2.88110120177088 0.000660015570902196 yes 47 0.00198144187924976 55 5967872
SGTC_1065 prochlorperazine maleate 2.48 µM 2.86487857601377 0.000700989018477826 yes 48 0.00208584585504462 67 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2682 pyrogallin 40.03 µM 2.83899937672225 0.000771232606392056 yes 49 0.00226276226552693 88 822798 An ATP competetive kinase inhibitor.
SGTC_1260 0700-1617 7.75 µM 2.83289839793013 0.000788710423739713 yes 50 0.00230640225145361 105 2853078
SGTC_1365 1672-3266 55.4 µM 2.82577166530459 0.000809588227035164 yes 51 0.00235834364739674 77 6415873
SGTC_1725 st036284 20.55 µM 2.81944920770948 0.000828534448418022 yes 52 0.00240530718497074 93 707914
SGTC_994 3910-0338 138 µM 2.81364237493147 0.000846294074973939 yes 53 0.00244918446637962 113 3479481
SGTC_867 0518-0118 155 µM 2.7993580613062 0.000891481635989639 yes 54 0.00256021613404338 76 6848158
SGTC_2931 9014674 55.67 µM 2.78540927258316 0.000937738237447401 yes 55 0.00267300992064949 79 2996810
SGTC_1031 k035-0009 16 µM 2.78392559264659 0.000942785959072191 yes 56 0.00268526764693647 100 5180959
SGTC_1367 1812-0510 76.9 µM 2.75917733929569 0.00103074839652024 no 57 0.00289735397415479 91 1142582 YDR527W RBA50
SGTC_2793 7325131 81.82 µM 2.72278369050591 0.00117383369792938 no 58 0.00323672137965489 75 4176441
SGTC_1422 4031-0024 15.5 µM 2.71425340841934 0.00120990199273179 no 59 0.00332126663857913 69 782427
SGTC_2698 st077697 67.5 µM 2.66867479612083 0.0014203951054326 no 60 0.00380755713218074 69 3154499
SGTC_2163 5671233 125 µM 2.64633714944719 0.00153531828387068 no 61 0.00406843366129687 113 701023
SGTC_2502 avocadyne acetate 18.59 µM 2.64178833476498 0.00155973581028199 no 62 0.00412347886364239 124 3952079
SGTC_1761 st044296 37 µM 2.64114044827583 0.00156324225154718 no 63 0.00413137291920211 77 1826700
SGTC_1463 k081-0032 34.1 µM 2.63753049897629 0.00158291165630656 no 64 0.00417560577434265 51 977755
SGTC_1956 st077085 54 µM 2.59422157078765 0.00183712126185552 no 65 0.00474026837227189 112 24208685
SGTC_1201 1889-3372 45.9 µM 2.5828144521369 0.00190998769738978 no 66 0.00489990058638579 67 5392199
SGTC_1596 piperlongumine 63 µM 2.55516968323598 0.00209759418477618 no 67 0.0053068022088966 92 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1895 st058434 18.3 µM 2.54884888447858 0.00214277156073686 no 68 0.00540395606002944 96 5393175
SGTC_2137 5261020 140 µM 2.548087569654 0.00214827211682712 no 69 0.00541576389649328 124 763655
SGTC_1107 amlodipine 47 µM 2.50736233487642 0.00246185262186559 no 70 0.00608179763398874 127 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.50149840315226 0.00251026493425329 no 71 0.00618345000693298 95 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_61 0978-8327 98.565 µM 2.49579981656472 0.00255813521219774 no 72 0.00628367507424893 122 6150059 YHR072W ERG7
SGTC_778 3456-2434 196 µM 2.49232151953351 0.00258775819953721 no 73 0.00634555481799717 189 5539063
SGTC_717 1532-0246 73.2 µM 2.48938042729684 0.00261304754842674 no 74 0.00639829778080963 133 9561992
SGTC_2161 5662504 8.5105 µM 2.48599083856377 0.00264247015307476 no 75 0.00645956457004753 114 2859334
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.47398507380891 0.00274910613430912 no 76 0.00668076395216833 111 688662
SGTC_403 arphamenine a 50 µM 2.47186718999977 0.00276831533129355 no 77 0.00672047197532046 121 5487158 An arginine aminopeptidase inhibitor.
SGTC_1873 rapamycin 2 nM 2.46028838177827 0.00287549250389061 no 78 0.00694127077071696 198 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_654 1124-0271 80.9 µM 2.45971279026098 0.00288091670727913 no 79 0.00695241206412554 139 5403748
SGTC_3250 9135583 49.47 µM 2.45806896596029 0.0028964584567373 no 80 0.0069843173135994 80 7699353
SGTC_3232 9132874 49.47 µM 2.43003066111836 0.00317345158321429 no 81 0.00754877278657444 102 3784940
SGTC_1677 st019204 53.9 µM 2.42823046758471 0.00319202480553045 no 82 0.00758634910173581 138 3945625
SGTC_1181 1222-0449 220 µM 2.42486110720537 0.0032270507312471 no 83 0.007657122256355 129 658318
SGTC_624 k048-0052 28 µM 2.4188387734526 0.00329051773324885 no 84 0.00778506980225263 125 6835531
SGTC_1323 1348-1351 11.2 µM 2.41393260326614 0.00334304921979302 no 85 0.0078906906037907 99 6989654
SGTC_2715 st079500 56.4 µM 2.40691104806544 0.0034195424133817 no 86 0.00804404394374023 97 28246688
SGTC_2369 9071472 200 µM 2.3810800949425 0.0037146637402075 no 87 0.00863097911963111 143 17296037
SGTC_1955 wogonin 32.4 µM 2.37165145708564 0.00382795200952559 no 88 0.00885439354284467 111 5281703 A flavanone.
SGTC_680 0417-1641 114 µM 2.36547005881622 0.00390389451128421 no 89 0.0090035996405592 125 2835990
SGTC_1921 5740136 50 µM 2.36470720961764 0.00391335957589225 no 90 0.00902216504408664 207 1774243
SGTC_2096 5468907 200 µM 2.34466679620589 0.00416949037570341 no 91 0.00952204513742697 109 759785
SGTC_1784 st039334 36.3 µM 2.33639094395594 0.00427956578511157 no 92 0.00973543775330352 139 3496984
SGTC_2156 5649887 115 µM 2.33360462189692 0.00431720650431474 no 93 0.00980821718113998 145 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_824 1304-0008 100 µM 2.33171463895795 0.00434290664881217 no 94 0.00985785409227703 170 768245
SGTC_2855 9016525 58.44 µM 2.32306549024141 0.0044622714987649 no 95 0.0100878172605282 147 43811474
SGTC_1847 st056231 15 µM 2.32283525474476 0.00446548857861614 no 96 0.0100940021859235 202 5393180
SGTC_2849 9019321 12.99 µM 2.31462435616051 0.00458158223930464 no 97 0.0103167493760789 168 16489627
SGTC_969 1313-0238 134 µM 2.3140383774264 0.00458996946125397 no 98 0.0103328085487202 174 5212874
SGTC_1531 st059297 52.4 µM 2.28853631002187 0.00496852397359053 no 99 0.0110531540463714 147 7566702
SGTC_1826 st055655 41.6 µM 2.27606821731124 0.00516353181129439 no 100 0.011420963492193 174 676168
SGTC_598 3937-0236 20.2 µM 2.26460720404907 0.00534876651326294 no 101 0.0117683972242183 179 1379313
SGTC_1915 st067105 30.6 µM 2.26328669316384 0.00537048397105079 no 102 0.0118090110217049 196 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_602 3130-1533 38.1 µM 2.25401169215359 0.00552524473116653 no 103 0.0120977162154852 176 720941
SGTC_1332 1480-0653 17.5 µM 2.24390214179722 0.00569843201100023 no 104 0.0124193491612397 158 5749438
SGTC_861 0443-0273 110 µM 2.24083334011865 0.00575194882191121 no 105 0.0125184362290323 138 6149169
SGTC_1087 pterostilbene 9.05 µM 2.23655391361067 0.00582732232388669 no 106 0.0126577549460627 176 5281727 Similar to reservatol, lowers cholesterol.
SGTC_503 tyrphostin 8 294 µM 2.22249966378822 0.00608106088972391 no 107 0.0131247783644563 190 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2673 kobusone 100 µM 2.2209800321012 0.0061090748331882 no 108 0.0131761569336039 92 6710676 An epoxy ketone and protein crosslinker.
SGTC_1313 1220-0047 237 µM 2.21800036340161 0.00616433622358938 no 109 0.0132774038195003 202 3528706
SGTC_3322 9139058 2.11 µM 2.21500882151275 0.00622026282725152 no 110 0.0133797295168122 175 4908926 YPR165W RHO1
SGTC_442 cape 100 µM 2.21119131426084 0.00629228310253519 no 111 0.0135112958047168 123 5281787
SGTC_147 4466-0538 29.23 µM 2.21020590657452 0.00631099306009815 no 112 0.0135454376204645 185 6742687 YHR072W ERG7
SGTC_2595 hexamethylquercetagetin 100 µM 2.20149533850516 0.00647853431202599 no 113 0.0138504881677396 164 386331
SGTC_2113 5491891 107.031 µM 2.19102252967282 0.0066851710972089 no 114 0.0142250810652613 187 789979
SGTC_1545 lovastatin 49.4 µM 2.19041727245079 0.00669728941182507 no 115 0.0142469942436859 208 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2040 5100729 123 µM 2.16929820582201 0.00713247044887855 no 116 0.0150300256838649 191 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3113 9123498 49.47 µM 2.15705372564028 0.00739604591465347 no 117 0.0155007392827774 132 8897275
SGTC_2196 6573537 42.6665 µM 2.15418774996848 0.0074589650205332 no 118 0.0156127255726576 135 2903087
SGTC_2285 7945142 200 µM 2.15333881979422 0.00747769258858536 no 119 0.0156460300009753 186 2970608
SGTC_1070 indatraline 8.81 µM 2.14858812038844 0.00758326041198597 no 120 0.0158335321078276 178 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.14610108636454 0.00763904777194545 no 121 0.0159324573167344 268 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1796 st049173 110.4 µM 2.13777088582632 0.00782854557250033 no 122 0.016267671528432 123 94134
SGTC_3167 9103034 49.47 µM 2.13765705061338 0.00783116351942336 no 123 0.0162722938767318 91 5127859
SGTC_2014 4013930 200 µM 2.12958263001177 0.00801883247963881 no 124 0.0166030431807043 220 64556
SGTC_1922 5578187 25 µM 2.12293358105894 0.00817632922385791 no 125 0.0168797089851916 213 1350412
SGTC_2079 5212404 121 µM 2.11661885513832 0.00832841651754358 no 126 0.0171461042852849 153 758462
SGTC_7 0192-1582 4.227 µM 2.10430091957582 0.00863225143689862 no 127 0.0176761029517621 277 252616
SGTC_751 0833-0568 350 µM 2.0935240185441 0.00890600481409837 no 128 0.0181512011421122 184 6954252
SGTC_2032 5185112 25.99 µM 2.09250397923096 0.00893230559141766 no 129 0.0181967280831488 164 5718189
SGTC_652 0437-0092 114 µM 2.08554313324227 0.00911360811936313 no 130 0.0185100135611475 166 3091274
SGTC_2625 euphol 100 µM 2.0821157532622 0.00920405577069353 no 131 0.0186659489773003 225 6708538 A triterpene alcohol.
SGTC_928 2764-0428 58.7 µM 2.08095940465054 0.00923474826646928 no 132 0.0187188109843244 246 662578
SGTC_2057 5236571 38.335 µM 2.08066672100341 0.00924253104179291 no 133 0.0187322110860787 259 54684039 YBR257W POP4
SGTC_1160 4092-0570 10.5 µM 2.07886662108069 0.00929052398649982 no 134 0.0188148057161984 234 4994975
SGTC_2919 7978188 46.38 µM 2.07700479003741 0.00934039202845443 no 135 0.0189005585610943 185 2980291
SGTC_565 1418-0001 44.5 µM 2.07265417339224 0.00945783461398936 no 136 0.0191022377488944 227 2862145
SGTC_2743 auranofin 4.32 µM 2.06343561276947 0.00971095935463861 no 137 0.0195356296575209 192 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1175 0741-0056 27.6 µM 2.06179552774687 0.00975660801131409 no 138 0.01961360352192 220 765927
SGTC_1554 st069299 38.7 µM 2.05952696850982 0.0098200579723703 no 139 0.0197218921326912 206 24207999
SGTC_1801 st050089 28.441 µM 2.05059371697813 0.0100734313837747 no 140 0.0201532643795857 335 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2881 9058953 51.95 µM 2.0352500818339 0.0105219505775988 no 141 0.0209128580694407 246 17122249
SGTC_1131 3454-3128 32.3 µM 2.03231673821199 0.0106096506299297 no 142 0.0210608005171096 256 710982
SGTC_163 TUB2.036 7.546 µM 2.02992152085436 0.0106817335320844 no 143 0.0211822585767711 385 15992207 YJR013W GPI14
SGTC_1499 4480-0877 67.3 µM 2.02214385663903 0.0109187474653053 no 144 0.0215807461871882 138 2861909
SGTC_3096 9117468 49.47 µM 2.00365790056086 0.0115005249635528 no 145 0.0225533594529422 128 41316311
SGTC_1396 3511-0007 98.6 µM 1.99059752971139 0.0119276127430995 no 146 0.0232625760309176 192 X1396
SGTC_571 k831-0106 44.2 µM 1.9845960856388 0.0121284359318181 no 147 0.0235947141015293 206 4783639
SGTC_90 0870-0863 4.608 µM 1.96403542939011 0.0128388276667204 no 148 0.0247629916849132 270 1738164
SGTC_1722 st034304 3.6505 µM 1.96221606846299 0.0129033876880217 no 149 0.0248686669745014 254 4036148 YLR033W RSC58
SGTC_2736 butenafine 14.65 µM 1.96035634839838 0.0129696698204934 no 150 0.024977077082709 269 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_791 1348-1292 225 µM 1.95935947251263 0.013005320436344 no 151 0.0250353516840759 307 5437054
SGTC_3333 9141820 12.094 µM 1.95877246245409 0.0130263528970341 no 152 0.0250697199532248 187 1939433
SGTC_2778 tioconazole 65.09 nM 1.95726033563294 0.0130806675991479 no 153 0.0251584341612332 303 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_684 1140-0066 328 µM 1.95639307101582 0.0131119074750129 no 154 0.0252094338904025 272 6813534
SGTC_199 4063-0024 41.6 µM 1.93975605686903 0.0137237957942701 no 155 0.0262046716939756 191 306215
SGTC_2927 9011802 47.9 µM 1.93949873143397 0.0137334501595007 no 156 0.0262203194235051 247 43912568
SGTC_1727 st034309 9.9045 µM 1.93671149417076 0.0138383980260578 no 157 0.0263903099656094 319 870305
SGTC_1461 k072-0203 53.8 µM 1.93357837997836 0.0139571942124982 no 158 0.0265824937960665 231 5418714
SGTC_2456 5770359 74.46 µM 1.93289295110105 0.0139833000501746 no 159 0.0266246932040338 226 3118787
SGTC_2158 5657123 3.6195 µM 1.93109537379481 0.01405196416941 no 160 0.0267356295091861 193 2858827
SGTC_526 4469-0568 170 µM 1.92149908522947 0.0144234616416709 no 161 0.0273344087920363 265 2901964
SGTC_1249 0481-0015 10.2 µM 1.90879560815043 0.0149282297240592 no 162 0.028144231825015 226 4227577
SGTC_2634 4'-methoxyflavone 100 µM 1.90826312706047 0.0149497152337369 no 163 0.0281786081021957 238 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_319 1348-1596 45.5 µM 1.9029500496496 0.0151655567934145 no 164 0.0285235316608644 238 5380505
SGTC_2466 5983409 37.09 µM 1.90228712816808 0.0151926746615467 no 165 0.0285668137680845 233 2879657
SGTC_932 2857-0803 154 µM 1.89776728195048 0.0153786787988795 no 166 0.0288633724897066 257 674898
SGTC_1659 st012954 42.1 µM 1.89713777627189 0.0154047391916001 no 167 0.0289048782962377 215 24207262
SGTC_2800 7887935 81.82 µM 1.89305295721382 0.0155747662588502 no 168 0.0291754136414539 248 2961002
SGTC_2909 7941780 10.49 µM 1.89196569993562 0.015620292871348 no 169 0.0292477755011043 258 1243215
SGTC_361 000s-0510 1.45 µM 1.88956116306359 0.0157213834732615 no 170 0.0294083377169898 286 660
SGTC_2268 7933382 153.85 µM 1.88337305062059 0.0159841258091699 no 171 0.0298249149423404 315 935025 YOR257W CDC31
SGTC_3339 9145883 14.936 µM 1.88131929954306 0.0160721543404591 no 172 0.0299642486104213 233 2030670
SGTC_2174 5790901 200 µM 1.88027215321524 0.0161171971601482 no 173 0.0300354982143889 281 786020
SGTC_1824 st053723 68.6 µM 1.87993332172432 0.0161317950829661 no 174 0.0300585829414824 262 675225
SGTC_2303 7774051 200 µM 1.87948383179386 0.0161511780007741 no 175 0.0300892295735693 251 2953184
SGTC_2649 anisomycin 9.56 µM 1.87713954839573 0.0162525919952215 no 176 0.0302494851174077 184 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1022 4477-0945 21.3 µM 1.87111114350292 0.0165158896323017 no 177 0.0306648386698244 276 4648966
SGTC_2464 5717415 7.67 µM 1.86969974780638 0.016578058808676 no 178 0.0307627622869904 261 5285744
SGTC_2368 9071271 200 µM 1.86373673099889 0.0168429331863936 no 179 0.0311793422632591 283 27209959
SGTC_1254 0550-0035 264 µM 1.85920958907861 0.0170464360538673 no 180 0.0314987180760144 286 15121435
SGTC_2384 9036245 200 µM 1.85860322035469 0.0170738523362723 no 181 0.0315417001545258 264 6462766
SGTC_1794 st048918 76.9 µM 1.85808395766479 0.0170973601641816 no 182 0.031578546297626 183 672303
SGTC_771 0250-0039 27.3 µM 1.85801295357526 0.0171005767783876 no 183 0.0315835874107218 247 3005115
SGTC_2746 daunorubicin 9.88 µM 1.85612543777328 0.0171862744859358 no 184 0.0317178403576951 129 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2445 5742597 35.57 µM 1.85314106368972 0.017322520885822 no 185 0.0319310712204375 248 1774255
SGTC_1519 esterone 74 µM 1.85155832619597 0.0173951516521156 no 186 0.0320446359799019 283 698 A steroid.
SGTC_3095 9117207 49.47 µM 1.84234985415813 0.0178229002086014 no 187 0.0327119958884435 186 17015229
SGTC_1663 st014140 55.4 µM 1.82516725182844 0.0186450760875191 no 188 0.0339878970153729 295 4207120
SGTC_2805 7950783 58.44 µM 1.82244864570885 0.0187780733028999 no 189 0.0341934695705304 313 1178958 YDL195W SEC31
SGTC_3177 9107506 49.47 µM 1.7973623331804 0.0200438646280375 no 190 0.0361390582178029 204 8897194
SGTC_3049 9092223 49.47 µM 1.79489489939511 0.0201721863026754 no 191 0.0363352233792012 255 8623917
SGTC_1936 st074407 74.3 µM 1.78736088182882 0.0205683202962221 no 192 0.0369395899074528 349 809813
SGTC_2426 5582046 32.21 µM 1.77621802986179 0.0211662738123253 no 193 0.0378484938160148 314 2251934
SGTC_26 0302-0163 425.158 µM 1.77464397703302 0.0212519153380496 no 194 0.0379783455194851 253 3100915
SGTC_3166 9102297 49.47 µM 1.76956350409972 0.0215303372697834 no 195 0.0383999415442887 322 25237072
SGTC_770 0389-1121 67.2 µM 1.76929681236953 0.0215450373757815 no 196 0.0384221775611074 353 6753108
SGTC_408 cantharidin 100 µM 1.76825609383177 0.0216024831703102 no 197 0.0385090502019366 333 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1620 st003704 16.5 µM 1.76798581441578 0.0216174232631763 no 198 0.0385316375948965 251 2834414
SGTC_211 3455-0679 143.504 µM 1.76711517457488 0.0216656085367872 no 199 0.0386044708425322 317 748649
SGTC_780 0109-0199 192 µM 1.76122635410104 0.0219939117279404 no 200 0.0391000495935202 336 610414
SGTC_744 1594-0068 283 µM 1.76036724979306 0.0220421562834313 no 201 0.0391727792467811 351 668392
SGTC_1104 tacrolimus 29.8 µM 1.76017902462235 0.0220527383300985 no 202 0.0391887286222639 316 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1276 0871-0068 94.2 µM 1.75766099573475 0.02219471518953 no 203 0.0394026040871452 270 3414906
SGTC_1155 4088-0394 48.2 µM 1.7508887074064 0.0225803966097023 no 204 0.0399825411749176 313 2326248
SGTC_671 0560-0003 407 µM 1.74913078907368 0.0226814286712419 no 205 0.0401342071082976 283 3238678
SGTC_2313 7726885 200 µM 1.73713698278678 0.0233809600504737 no 206 0.0411814974344049 314 726423
SGTC_2139 5578692 56.4705 µM 1.73318755227835 0.0236152454453034 no 207 0.0415311693737333 268 650991 YMR113W FOL3
SGTC_2779 methotrexate 400 µM 1.72384919230952 0.0241770726622512 no 208 0.0423675357208345 325 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3069 9117009 49.47 µM 1.7205198355906 0.0243800741142481 no 209 0.0426689956226058 204 41904981
SGTC_1893 st059353 36.1 µM 1.71754093724844 0.0245629181566152 no 210 0.0429401906667951 332 3112488
SGTC_628 1636-0253 16 µM 1.70366707797365 0.0254297208483942 no 211 0.0442216510105005 352 4456143
SGTC_2586 curcumin 80 µM 1.69991433987874 0.0256685366304282 no 212 0.0445735196005189 407 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1509 1326-1131 80 µM 1.69102420865042 0.0262417847676498 no 213 0.0454160895625879 294 768313
SGTC_1062 mesoridazine 14.2 µM 1.68024557751871 0.0269511226588734 no 214 0.0464547724531872 348 4078 A neuroleptic.
SGTC_1063 disulfiram 1.84 µM 1.67717515461807 0.0271560908325577 no 215 0.0467541179811578 347 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2920 7982904 15.77 µM 1.67209706088951 0.0274979360268341 no 216 0.0472525920545079 306 6456808
SGTC_2857 9024691 58.44 µM 1.66586935913198 0.0279220606472885 no 217 0.0478697188579986 326 16478292
SGTC_2924 9010168 62.78 µM 1.66450442860246 0.0280157407688487 no 218 0.0480058333957794 369 2993929
SGTC_250 brefeldin a 552.239 µM 1.66202206310914 0.0281867853839539 no 219 0.0482541753937697 256 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_923 1900-2434 73.3 µM 1.66174951930837 0.0282056175607852 no 220 0.0482815038529142 339 5910570
SGTC_1932 st074806 40.9 µM 1.65676688907115 0.0285517565303276 no 221 0.0487833068351041 377 17251235
SGTC_1704 st028805 70.8 µM 1.65296054893374 0.0288185540345435 no 222 0.0491694464361008 313 2876101
SGTC_938 3126-1755 342 µM 1.64349161958965 0.0294912607883476 no 223 0.0501406289248687 338 1777771
SGTC_822 1487-0950 154 µM 1.64051347797739 0.0297055143433457 no 224 0.0504492242136658 335 1958375
SGTC_21 0849-0113 22.993 µM 1.6374265025357 0.0299289592527325 no 225 0.0507706921769 364 1560156
SGTC_2160 5660466 132.927 µM 1.63116987464971 0.0303861102934718 no 226 0.0514272400088731 343 2859134
SGTC_2012 4023501 200 µM 1.6302823397672 0.0304514256811593 no 227 0.0515209191478098 343 3477460
SGTC_1865 st057639 52.2 µM 1.61842414029147 0.0313353062518821 no 228 0.052785611521615 364 688818
SGTC_2307 7538926 6.34 µM 1.61144933783116 0.0318650274114462 no 229 0.05354091050537 394 96582
SGTC_922 1866-0035 480 µM 1.6087747422883 0.0320701095150833 no 230 0.0538328028348589 450 3156169
SGTC_2203 7227154 166.4 µM 1.60466587777926 0.0323872903341317 no 231 0.0542836775449095 327 896304
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.59971193818883 0.0327731431720653 no 232 0.0548312511201151 357 16623 A steroid.
SGTC_1001 4048-4355 44.4 µM 1.59927591102994 0.0328072852025389 no 233 0.0548796547885108 362 21824233
SGTC_336 4111-0029 111 µM 1.59901835655309 0.032827466141972 no 234 0.0549082619460939 309 3131175
SGTC_282 k297-0036 65.7 µM 1.5979587065719 0.0329106037735955 no 235 0.0550260836706202 310 5061378
SGTC_1441 4106-0040 13 µM 1.59155361977242 0.0334168339794807 no 236 0.0557425191982639 354 2904180
SGTC_3277 9138724 49.47 µM 1.59032881850032 0.0335143634634678 no 237 0.0558803529779417 272 15943418
SGTC_856 0433-0016 11.3 µM 1.58945344513482 0.0335842118993283 no 238 0.0559790283220506 392 3911780
SGTC_2258 7960471 200 µM 1.58773911480415 0.0337213501115683 no 239 0.0561726721219886 290 2974708
SGTC_206 4546-0025 72.014 µM 1.585506646055 0.0339006273194828 no 240 0.0564256340547618 457 6620745 YIL048W NEO1
SGTC_579 4491-1009 110 µM 1.58418309338023 0.0340072841865104 no 241 0.0565760297467003 492 1271041
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.57296837810161 0.0349221271272915 no 242 0.0578630702358972 442 6728940
SGTC_853 0419-0306 21 µM 1.57291360120163 0.0349266446573962 no 243 0.0578694126429663 348 762713
SGTC_1116 jasmonic acid 1.58368 µM 1.57163736677668 0.0350320334096496 no 244 0.0580173376792082 392 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3115 9123671 49.47 µM 1.57130646500088 0.0350594011453671 no 245 0.0580557401216867 347 3286988
SGTC_382 3229-0966 23.2 µM 1.56745173899913 0.0353795066440691 no 246 0.0585045692240941 401 5722370
SGTC_1652 st011932 78 µM 1.56579566957521 0.0355177646790474 no 247 0.0586982301788603 361 1551076
SGTC_2610 ononetin 44.17 µM 1.56552155786653 0.0355406917448398 no 248 0.0587303333156031 441 259632
SGTC_2619 obliquin 87.91 µM 1.55520724741699 0.0364122505249146 no 249 0.0599483594026461 519 6708593 A bioactive alkalod. YER133W GLC7
SGTC_370 0180-0345 38.7 µM 1.55321501914384 0.0365825930029528 no 250 0.0601858871871517 348 3989527
SGTC_1194 1488-0194 225 µM 1.55229539917499 0.036661443361397 no 251 0.060295779141962 441 1391452
SGTC_773 4358-1457 44.6 µM 1.55016581572077 0.0368445726017138 no 252 0.0605508611801951 457 1186886
SGTC_2295 7971645 200 µM 1.54379522705395 0.0373968683932996 no 253 0.0613189739918369 412 2978226 YKL099C UTP11
SGTC_613 3914-0030 117 µM 1.54006215520905 0.0377236356915719 no 254 0.0617726017505643 152 1145395
SGTC_2390 9097792 176.6 µM 1.53790555729814 0.0379134690479664 no 255 0.0620358541576856 369 4497149
SGTC_1428 4049-0204 61.7 µM 1.53547149452054 0.0381286616938936 no 256 0.0623340269192172 410 X1428
SGTC_1064 honokiol 6.76 µM 1.53409358864275 0.0382509216713778 no 257 0.0625033151880941 415 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2103 5378138 10 µM 1.53395010863223 0.0382636708406253 no 258 0.0625209635978039 444 244142
SGTC_24 0417-1663 219 µM 1.52107517068256 0.0394218777731974 no 259 0.0641204872546666 403 4329390
SGTC_1479 0549-0158 134 µM 1.51723923493255 0.0397724146506371 no 260 0.0646031468588025 442 5440202
SGTC_765 1319-0117 244 µM 1.51179068428282 0.040274667761173 no 261 0.0652935600195749 376 3487746 YGL099W LSG1
SGTC_432 NS 1619 61.3 µM 1.51011510739975 0.0404301558020199 no 262 0.0655070276234629 390 4552 A K+/calcium channel activator.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.50798587377471 0.0406284445425607 no 263 0.0657790712404476 431 3256 An antibiotic and ribosome inhibitor.
SGTC_1737 st035557 69.7 µM 1.50353411025457 0.041045573563742 no 264 0.0663506838636718 352 5716916
SGTC_2695 st077686 51.995 µM 1.49697987972654 0.0416660173638898 no 265 0.0671992467378625 393 2876092
SGTC_355 1311-2252 105 µM 1.49577661443753 0.0417807433759665 no 266 0.0673559386958404 440 5338538
SGTC_427 1354-0053 47.3 µM 1.49177206567892 0.0421644029582892 no 267 0.0678794546907873 434 6813657
SGTC_1735 st034310 56.75 µM 1.48235171979363 0.0430781750811082 no 268 0.0691233666451445 439 871153
SGTC_2319 6033012 152.6 µM 1.47881191625573 0.0434256435868719 no 269 0.0695952950720044 360 847246
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.47420915647122 0.0438808322298542 no 270 0.0702126426385427 457 5393153
SGTC_3085 9117376 49.47 µM 1.46715048311992 0.0445863665207158 no 271 0.0711675618266124 431 16480349
SGTC_2812 7970281 58.44 µM 1.46411469440377 0.0448925990070895 no 272 0.0715813064816611 461 2233435
SGTC_1462 k081-0014 26.5 µM 1.46303426051172 0.045001994507488 no 273 0.071729002227756 301 3270634
SGTC_2659 sanguinarine 24.21 µM 1.46051531705251 0.0452578745220434 no 274 0.0720742505149271 447 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_273 hydroxyurea 18.1 mM 1.4441257173711 0.046951475288293 no 275 0.0743518075828961 522 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1896 st058441 89 µM 1.44011818904566 0.0473732285644167 no 276 0.07491698193872 415 688759
SGTC_1237 0330-0133 46.1 µM 1.43899439589782 0.0474920402731239 no 277 0.0750760552773257 430 X1237 YHR072W ERG7
SGTC_1176 0848-0131 83.3 µM 1.43492659242115 0.0479241012115324 no 278 0.0756540084888713 509 6769040
SGTC_2700 st077718 96.8 µM 1.43361326829713 0.0480642656821796 no 279 0.0758413275041926 414 904970
SGTC_2028 5153890 36.43 µM 1.43328205713071 0.0480996659340007 no 280 0.0758886237776775 451 2830968 YPR165W RHO1
SGTC_3056 9094900 49.47 µM 1.43012488628124 0.0484381564978368 no 281 0.076340589387332 462 25236784
SGTC_1217 1183-1422 255 µM 1.42602868040319 0.0488801602337529 no 282 0.0769300317680417 468 2849664
SGTC_1144 3486-0183 12.5 µM 1.42384464821432 0.0491171436087037 no 283 0.0772457239080415 491 6744069
SGTC_1468 k284-1086 134 µM 1.42228554438866 0.0492868784205514 no 284 0.0774716868248543 545 15996457
SGTC_237 nikkomycin 200 µM 1.4208666856721 0.0494417519261487 no 285 0.0776777597957516 488 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2256 7954252 200 µM 1.42002458917204 0.0495338533143637 no 286 0.0778002612875979 370 2972920
SGTC_1504 k297-0033 30 µM 1.41810424736378 0.049744396235947 no 287 0.0780801657069062 380 4388117
SGTC_348 k064-0012 10.7 µM 1.41377973097261 0.0502211429829044 no 288 0.0787132933106554 435 5066323
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.41285040775819 0.0503240680745078 no 289 0.0788498566258738 506 2333 A French combination drug.
SGTC_1109 tnp00067 928.257 nM 1.41176267210036 0.0504447512340708 no 290 0.0790099264419946 465 676295
SGTC_919 tnp00227 403.569 nM 1.40138942274417 0.0516072718669169 no 291 0.0805488267570441 531 1269246 A methoxyflavone. YNL221C POP1
SGTC_1613 st002381 52.1 µM 1.39631463761426 0.0521837065305791 no 292 0.0813098839091737 475 551167
SGTC_233 rapamycin 362 pM 1.3959655142179 0.0522235500100993 no 293 0.0813624401235485 477 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1290 0986-0249 10.2 µM 1.39239189781314 0.0526327773680665 no 294 0.0819018783072356 434 53329
SGTC_1423 4048-0112 5.59 µM 1.39153944772744 0.0527307693684314 no 295 0.0820309530883605 484 X1423
SGTC_855 0428-0020 25 µM 1.39114475111818 0.052776190071349 no 296 0.0820907684460775 444 6812414
SGTC_882 0843-0131 351 µM 1.38988537083224 0.052921323974092 no 297 0.0822818443025471 513 5425421
SGTC_1769 st044406 64.4 µM 1.38032527291483 0.054033398975416 no 298 0.0837432584450422 537 670903
SGTC_42 0133-0086 60.653 µM 1.37629133586315 0.0545081598005846 no 299 0.0843657271163236 449 162923 Model of phenazepam hydroxylation.
SGTC_60 0986-0278 202 µM 1.37554409156982 0.0545964653243642 no 300 0.0844814130295674 364 3110598
SGTC_301 4119-0100 24.5 µM 1.37235032199292 0.0549751644015384 no 301 0.0849772035820211 558 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3044 9093193 49.47 µM 1.3717870753801 0.0550421657945475 no 302 0.0850648659569524 519 25236277
SGTC_816 0325-0417 81.3 µM 1.37039508555244 0.055208027680357 no 303 0.0852818026763914 465 68101
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.36933816905711 0.0553342275403206 no 304 0.0854467960314074 545 23847180
SGTC_3101 9120531 49.47 µM 1.36750040458739 0.0555542059571511 no 305 0.0857342552687827 525 24824904
SGTC_2717 st081029 62.2815 µM 1.36028261588896 0.0564248540237823 no 306 0.086870253700422 458 5292846
SGTC_2531 methyl deoxycholate 70.07 µM 1.35508336701323 0.0570586518935703 no 307 0.0876954986997766 495 16667744 Haematoxylin.
SGTC_2310 7668677 200 µM 1.35473239461326 0.0571016371915045 no 308 0.0877514164226615 504 2197143
SGTC_3137 9097352 49.47 µM 1.35151053346035 0.0574974262451999 no 309 0.0882659739943457 554 44120435
SGTC_2493 resveratrol 26.09 µM 1.35104485402291 0.0575548106338229 no 310 0.0883405324357607 465 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1356 1502-0781 85.8 µM 1.35059150929304 0.0576107183138989 no 311 0.0884131610822007 509 567702
SGTC_2987 9018338 71.43 µM 1.34876181349801 0.0578367954420417 no 312 0.0887067419222843 517 5055682
SGTC_907 3448-6986 75.5 µM 1.34862146495103 0.0578541656628242 no 313 0.0887292912634407 566 590582
SGTC_2188 6126565 140.678 µM 1.34614187629982 0.0581617284066333 no 314 0.0891283828582543 447 874518
SGTC_3009 9080819 71.4286 µM 1.34428819206915 0.0583924933711529 no 315 0.0894276061986383 508 17027216
SGTC_2671 danthron 100 µM 1.34130558351691 0.0587653066112686 no 316 0.0899106288613338 506 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_702 1488-0190 94 µM 1.34097385596741 0.0588068863105944 no 317 0.0899644705255083 506 949357
SGTC_1420 4'-methoxyflavone 42 µM 1.33987200197518 0.0589451616312213 no 318 0.0901434809748476 494 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1958 st076513 41.9 µM 1.33962553218189 0.0589761268300952 no 319 0.0901835593747316 534 732122 YGL099W LSG1
SGTC_1215 3852-0577 11.2 µM 1.33754018752502 0.0592386298501414 no 320 0.0905231867282733 582 2884876
SGTC_2175 5807670 165.306 µM 1.33510182261866 0.0595467320709194 no 321 0.0909215115153651 493 241186
SGTC_3237 9133362 49.47 µM 1.3340996272559 0.0596737291419988 no 322 0.0910856039980077 502 43845137
SGTC_2557 derrustone 83.84 µM 1.33074291027948 0.0601006348575644 no 323 0.0916368092770494 568 629853 An antioxidant.
SGTC_1410 3909-8106 77.9 µM 1.33071476919828 0.0601042239083103 no 324 0.0916414407378101 503 1039210
SGTC_1135 dihydrocapsaicin 536.708 nM 1.32852540545784 0.0603839652225695 no 325 0.0920022982159435 536 107982 A Capsaicinoid.
SGTC_1002 4049-0206 172 µM 1.32521669785008 0.060808660539615 no 326 0.0925496443350409 576 4662749
SGTC_522 1273-0010 11.6 µM 1.31923921507419 0.0615818290658592 no 327 0.0935445759580709 513 5705015
SGTC_1564 D-Arginine 115 µM 1.31792199429297 0.0617532352676903 no 328 0.0937648810664602 526 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_140 0062-0056 502.533 µM 1.31716210978777 0.0618522861535009 no 329 0.0938921457970734 565 3758964
SGTC_1426 4048-4480 71.7 µM 1.31253238788056 0.0624584517636305 no 330 0.0946702827617759 557 14224343
SGTC_1208 2323-2347 50.3 µM 1.31061220910744 0.0627112139780587 no 331 0.0949944061276008 544 5412760
SGTC_1120 ficusin 1.78878 µM 1.30520094609681 0.0634278137881339 no 332 0.0959122160647608 554 6199 A DNA cross-linker.
SGTC_1114 scopoletin 1.73284 µM 1.30151287562139 0.063919856724543 no 333 0.0965414800997881 525 5280460 A coumarin with genotoxic properties.
SGTC_1854 st056233 32.9 µM 1.29783572392744 0.064413393087442 no 334 0.0971718954874296 527 5393174
SGTC_1145 3546-0597 10.2 µM 1.29768107985759 0.0644342136521935 no 335 0.0971984738961904 576 875334
SGTC_11 0438-0307 1.3 µM 1.29508306268537 0.064784781064712 no 336 0.0976457885309234 520 4011476
SGTC_1013 4112-3890 241 µM 1.29423396145428 0.0648996763909434 no 337 0.097792309649262 576 705171
SGTC_13 0199-0087 65 µM 1.29392130296923 0.0649420233032791 no 338 0.0978463026543749 572 4589825
SGTC_1636 st007707 68.9 µM 1.29388862104601 0.0649464510276363 no 339 0.0978519477580315 610 403051
SGTC_2452 5863136 48.41 µM 1.28578981087901 0.066050914065677 no 340 0.0992582135784872 537 2184096
SGTC_495 decylubiquinone 155 µM 1.28524344846652 0.066125944192345 no 341 0.0993536125203702 545 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1308 1187-1617 41.4 µM 1.28245450425709 0.0665099697075803 no 342 0.0998416274327181 600 2882570
SGTC_381 3461-2219 42.7 µM 1.28124870447771 0.0666765367366872 no 343 0.100053161927491 605 2883159
SGTC_1739 st037196 92.5 µM 1.27938594359695 0.0669344895474851 no 344 0.100380590635119 588 612214
SGTC_430 0958-0115 16.4 µM 1.27674554096899 0.0673014510016239 no 345 0.100846048848312 546 6833180
SGTC_1399 3562-5772 25 µM 1.27205880141752 0.0679566389030562 no 346 0.10167611385507 479 23847490
SGTC_1328 1441-0025 69.2 µM 1.26592985937546 0.0688208593861384 no 347 0.102769097521086 521 4562601
SGTC_3034 9090421 49.47 µM 1.26410385259775 0.0690799697161052 no 348 0.103096377006122 511 17173761
SGTC_3233 9132340 49.47 µM 1.26242991130606 0.0693181618498523 no 349 0.103397065886024 552 17682950
SGTC_2013 4024628 200 µM 1.25680266366121 0.0701235263477172 no 350 0.104412550646027 537 5230760
SGTC_1951 sophoraflavanone G 9.2 µM 1.2531960944843 0.0706434664947708 no 351 0.105067175474541 623 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_251 melphalan 456.522 µM 1.25300210181882 0.0706715171435936 no 352 0.105102470892207 653 460612 A DNA alkylator.
SGTC_575 k072-0246 11.9 µM 1.25215502222454 0.0707941021367129 no 353 0.105256690809641 584 6796779
SGTC_1464 k208-0027 110 µM 1.25172556916394 0.0708563127467144 no 354 0.105334939857869 599 X1464
SGTC_2903 5923464 63.88 µM 1.25083085236985 0.0709860563902694 no 355 0.105498098035033 555 2876576
SGTC_2376 9072922 81.32 µM 1.24874698869943 0.0712889465807189 no 356 0.105878814297214 599 17087968
SGTC_184 1494-0393 24.714 µM 1.24485184137027 0.0718577665221257 no 357 0.106593107988048 603 3090647
SGTC_281 1672-3440 14.9 µM 1.24245433000452 0.0722096088506195 no 358 0.107034490399732 636 6833000
SGTC_3140 9094243 49.47 µM 1.24173434668065 0.0723155260454924 no 359 0.10716729652451 601 19291112
SGTC_3000 9075062 71.4286 µM 1.23947611524798 0.0726485082259282 no 360 0.107584614367888 561 17057871
SGTC_1484 3473-2379 286 µM 1.23937164153911 0.0726639415207786 no 361 0.10760394925607 703 671917
SGTC_1448 4255-0083 152 µM 1.23417120612753 0.0734353490916707 no 362 0.108569557222739 601 5399660
SGTC_748 act1.228 77.9 µM 1.23227168852673 0.0737186707496972 no 363 0.108923805924788 639 4421505 YNR035C ARC35
SGTC_368 fentichlor 4.58 µM 1.23214539911831 0.0737375369692061 no 364 0.108947387570487 500 7329 A pesticide.
SGTC_1445 4239-0156 97.7 µM 1.23116635344541 0.0738839206298775 no 365 0.109130326372686 687 4008346
SGTC_972 1319-0219 195 µM 1.2294723851758 0.0741377215286679 no 366 0.109447372665382 598 23903702
SGTC_1053 3366-3204 134 µM 1.22794829343259 0.0743666391071573 no 367 0.109733189423775 615 3632071 YPR165W RHO1
SGTC_1814 st052110 31.539 µM 1.22653332854191 0.074579648658784 no 368 0.10999902061888 566 674163
SGTC_550 4123-0385 25.7 µM 1.22597989415458 0.0746630895376573 no 369 0.110103120625427 580 5731123
SGTC_1567 st069303 68.4 µM 1.22369157522989 0.0750088540706002 no 370 0.110534299497489 630 5581319
SGTC_2674 ligustilide 100 µM 1.2232330700928 0.0750782807371884 no 371 0.110620839169037 547 5319022 A signalling regulator.
SGTC_2816 7982706 58.44 µM 1.22205673418372 0.075256625191904 no 372 0.110843086516991 579 2981853
SGTC_583 1488-1091 88.9 µM 1.21588116179134 0.0761982070791117 no 373 0.112015097619406 728 4303273
SGTC_2687 chenodiol 100 µM 1.21391110197169 0.07650045841461 no 374 0.112390836495897 578 5702181 A cholesterol synthesis inhibitor.
SGTC_142 0335-0849 62.6745 µM 1.21135645789542 0.0768937551351457 no 375 0.112879409761383 736 3889043 YPR107C YTH1
SGTC_2814 7977482 42.97 µM 1.20970549605012 0.0771487431650222 no 376 0.113195960085262 684 6456762
SGTC_473 2-arachidonoylglycerol 10 µM 1.20795791253836 0.0774193537069652 no 377 0.113531725834884 593 5282280 An endocannabinoid.
SGTC_2496 diffractaic acid 79.83 µM 1.20401594437864 0.0780324076029789 no 378 0.114291707976926 642 94870 An apoptosis inducer which activates caspases.
SGTC_47 0149-0135 24.25 µM 1.19850353660103 0.0788958628542423 no 379 0.115360523509694 590 5239155
SGTC_3039 9090270 49.47 µM 1.19296881710399 0.0797700754942234 no 380 0.116440792850718 578 17173750
SGTC_523 1934-0222 13.7 µM 1.19220676420537 0.0798910139055094 no 381 0.116590090898975 631 1361595
SGTC_1637 st007924 17.4 µM 1.19156726827432 0.079992609386361 no 382 0.116715482845333 619 683336
SGTC_2339 9000433 200 µM 1.18988844314555 0.0802597859031544 no 383 0.117045120686998 557 2988954
SGTC_130 0136-0219 337.655 µM 1.18917636666796 0.0803733127458958 no 384 0.117185136185824 660 234244
SGTC_1381 2324-0066 62.1 µM 1.18131190600366 0.0816352307938904 no 385 0.118739419640603 617 10885928
SGTC_2168 5727979 200 µM 1.18108304473738 0.0816721758936122 no 386 0.11878486740929 571 695210
SGTC_1813 st051246 8.6015 µM 1.17988208077547 0.0818662542928326 no 387 0.119023558871504 591 5291959
SGTC_169 k015-0017 16.025 µM 1.17974372082994 0.0818886358716621 no 388 0.11905107963668 572 1840002
SGTC_1402 3909-7673 35.9 µM 1.17809386882125 0.0821558770272028 no 389 0.119379593033793 625 5328014
SGTC_1406 3909-7906 11.9 µM 1.17580798985947 0.0825272260505285 no 390 0.119835806442223 652 X1406
SGTC_572 0960-0087 17.7 µM 1.17441396232693 0.0827543101193816 no 391 0.12011462770364 670 6796365
SGTC_1259 0671-0132 43 µM 1.17323645367646 0.0829464897802087 no 392 0.120350498657898 638 X1259
SGTC_832 4083-0019 164 µM 1.1704127232209 0.0834087147566562 no 393 0.120917458969463 842 1990758
SGTC_2583 asiatic acid 100 µM 1.16925581108035 0.0835986513124939 no 394 0.121150290504873 618 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2928 9011484 9.79 µM 1.16836227668047 0.0837455700041284 no 395 0.121330332300605 596 2994751
SGTC_1901 st060216 58.6 µM 1.16540268410753 0.0842335839012003 no 396 0.121928015669825 659 688792
SGTC_1379 2144-0755 36.5 µM 1.16175217535087 0.0848384607613354 no 397 0.122668072712609 704 5392327
SGTC_2431 5490079 200 µM 1.15794799437901 0.0854722596913725 no 398 0.123442629951878 665 5722345
SGTC_2964 9083345 53.42 µM 1.1558404358567 0.0858249144077163 no 399 0.12387321500605 597 17741579
SGTC_2241 6772625 37.8075 µM 1.15563688052218 0.0858590326152022 no 400 0.123914858011844 625 2285411
SGTC_899 1083-0020 478 µM 1.15012415308115 0.0867868932785441 no 401 0.12504636984007 682 767123
SGTC_3231 9132313 49.47 µM 1.1496132063339 0.0868732699332821 no 402 0.125151608197896 666 4905967
SGTC_584 0986-0246 15.4 µM 1.14878461859548 0.0870134809949264 no 403 0.125322401683023 722 53315 YDR232W HEM1
SGTC_25 0118-0223 35.662 µM 1.1485748812248 0.0870489988993577 no 404 0.12536565980537 658 5333628
SGTC_612 0302-0167 22.4 µM 1.14192944907364 0.0881799817184081 no 405 0.126741673240492 736 235821
SGTC_3122 9126309 49.47 µM 1.14162826483684 0.0882314983695819 no 406 0.126804285064909 646 17591206
SGTC_2584 androsterone 48.74 µM 1.13930857467373 0.0886290263110458 no 407 0.127287236611661 824 2754130 A steroid.
SGTC_1150 3909-7983 10.9 µM 1.1387135809521 0.0887312057114645 no 408 0.127411318186027 691 23965914
SGTC_683 panaxydol 45 µM 1.13797117144513 0.0888588240962221 no 409 0.12756626017435 712 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3118 9124250 49.47 µM 1.1379019436009 0.0888707311561007 no 410 0.127580714804913 597 1504786
SGTC_118 0083-0097 135.343 µM 1.1326759839046 0.0897730197837868 no 411 0.128675173320702 887 5207356
SGTC_2841 9004761 38.96 µM 1.13262705058467 0.0897815004327935 no 412 0.128685451984704 587 2991039
SGTC_1377 2944-0135 198 µM 1.13061196394839 0.0901312531540335 no 413 0.129109224855146 680 1894137
SGTC_656 4090-1979 187 µM 1.12714407951063 0.0907355320183954 no 414 0.129840784551454 739 22330961
SGTC_2393 9031399 185.94 µM 1.12678296309983 0.0907986289843866 no 415 0.12991712771243 677 1526623 YDL150W RPC53
SGTC_944 3370-0224 231 µM 1.11890380571977 0.0921834508768681 no 416 0.131590589612972 682 4580514
SGTC_67 0335-0847 266 µM 1.11819189755162 0.0923093401426196 no 417 0.131742522022786 820 4552207 YOR254C SEC63
SGTC_1522 st012842 45.6 µM 1.11574816007825 0.0927424429743019 no 418 0.132264974696706 631 3491067 YOR116C RPO31
SGTC_1190 1486-1332 13 µM 1.11168684148342 0.0934655503434151 no 419 0.133136409692355 687 4150046
SGTC_213 1246-0773 967 nM 1.11033214214365 0.0937076748945394 no 420 0.133427963698521 728 6251622
SGTC_249 wiskostatin 11.211 µM 1.10897557907203 0.0939505962714175 no 421 0.133720358592775 724 2775510 A n-wasp and actin depolymerizer.
SGTC_2167 5876490 200 µM 1.10784692468386 0.0941530596857519 no 422 0.133963965312976 708 686534
SGTC_1149 3909-7961 23.3 µM 1.09844602850022 0.0958519565033474 no 423 0.136004886390642 698 735261
SGTC_2516 gossypol 71.55 µM 1.09694773057705 0.0961247938011727 no 424 0.136332120973087 745 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2389 9091542 195.52 µM 1.09544641211204 0.0963987533938345 no 425 0.1366605551535 735 3626624 YOL127W RPL25
SGTC_2396 5342950 42.78 µM 1.09210648959116 0.097010277411061 no 426 0.137393148658188 742 1886677
SGTC_1261 0712-0010 12.7 µM 1.09198958572557 0.0970317334188805 no 427 0.137418839355243 745 2840123
SGTC_1617 st002906 78 µM 1.08859878308802 0.097655582640943 no 428 0.138165426831169 735 5150859
SGTC_3216 9129716 49.47 µM 1.08753763532449 0.0978514184346559 no 429 0.138399637653194 653 8056934
SGTC_1789 tunicamycin 25 nM 1.08544247540375 0.0982389271000948 no 430 0.138862864249635 722 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2966 9084041 48.03 µM 1.08428219712357 0.0984540084856216 no 431 0.139119848161819 659 17741380
SGTC_2489 cantharidin 73.42 µM 1.08318515770209 0.0986576841783335 no 432 0.139363123171162 716 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1169 aniline yellow 25.8 µM 1.08147024324292 0.098976691792406 no 433 0.139743995164247 686 6051 A DNA damaging agent.
SGTC_399 oxolinic acid 75 µM 1.07359806576671 0.100450755366398 no 434 0.141501432450209 707 4628 A DNA gyrase inhibitor.
SGTC_1612 st002233 45.4 µM 1.07349427314952 0.10047029692883 no 435 0.141524703396003 717 1035021
SGTC_2235 salicylic acid 500 µM 1.06952400254508 0.101219883585102 no 436 0.142416809593984 730 338 A COX inhibitor and kinase inhibitor.
SGTC_1493 4348-0038 111 µM 1.06793514192493 0.10152099925188 no 437 0.142774884600443 790 800424
SGTC_196 k015-0023 18.111 µM 1.06729260613853 0.101642955611621 no 438 0.142919862931619 760 5211998
SGTC_1832 st054113 55 µM 1.06706721941844 0.101685760349751 no 439 0.142970741545043 707 1251267
SGTC_1699 st031318 29.054 µM 1.06618118580822 0.101854160283336 no 440 0.14317087266693 742 5340658
SGTC_2357 9067248 200 µM 1.06564508408817 0.101956150527089 no 441 0.143292055446656 691 9150235
SGTC_604 1000-0114 314 µM 1.06552303182772 0.10197938064474 no 442 0.143319654351489 799 1572745
SGTC_3032 9089427 49.47 µM 1.06507599107363 0.102064498474448 no 443 0.143420771497507 701 17173707
SGTC_2915 7971052 15.16 µM 1.06132171890061 0.102781363156644 no 444 0.144271859349775 575 5741558
SGTC_1092 toremifene 6.32 µM 1.06129974676219 0.1027855693991 no 445 0.144276850400463 794 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3181 9108277 49.47 µM 1.05972464326173 0.103087425756003 no 446 0.144634944100994 720 17097298
SGTC_409 arachidonic acid 100 µM 1.05702133025866 0.103606994557104 no 447 0.145250926353222 741 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2374 9071832 200 µM 1.05463886282614 0.104066470820183 no 448 0.145795261351801 720 17381698
SGTC_1278 0874-0585 172 µM 1.05151268744706 0.10467161534295 no 449 0.146511592695065 759 766306
SGTC_1931 st074438 57.1 µM 1.05147433328449 0.104679055483172 no 450 0.146520395806483 712 2787313
SGTC_2999 9069765 71.4286 µM 1.0488064465867 0.105197526395548 no 451 0.147133604924856 758 2097066
SGTC_488 nitrendipine 139 µM 1.04724299518368 0.105502226141135 no 452 0.147493759985692 795 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.04674629912361 0.105599160292759 no 453 0.147608301904838 779 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1743 st037606 46.3785 µM 1.04135328382516 0.106655797707934 no 454 0.148855807764113 746 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_975 1335-0046 28.5 µM 1.04052454773079 0.10681884356614 no 455 0.149048132700447 751 16486740
SGTC_2628 lathosterol 100 µM 1.03902934341976 0.107113465443897 no 456 0.149395544759484 769 6710616
SGTC_2061 5245884 80.95 µM 1.03852533626472 0.107212909256244 no 457 0.149512772993328 765 573863
SGTC_1547 harmine 94.2 µM 1.03712505224972 0.107489543543645 no 458 0.149838790561189 834 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_100 0086-0128 49.5915 µM 1.03505640115308 0.107899158399087 no 459 0.15032128602178 803 93297
SGTC_164 4100-3994 89.624 µM 1.03344313116247 0.108219382276212 no 460 0.150698285435831 836 4615967
SGTC_1271 0832-2808 169 µM 1.03211365095681 0.10848378936279 no 461 0.151009439816909 812 3663794
SGTC_2078 5212016 200 µM 1.03011360290417 0.10888243401891 no 462 0.151478340183113 743 1899708
SGTC_1430 4049-0248 69.1 µM 1.0286263905998 0.10917954347677 no 463 0.151827635899063 862 22774488
SGTC_2083 5306046 65.942 µM 1.0286015774862 0.10918450547952 no 464 0.151833468192979 761 539837
SGTC_2570 licareol 100 µM 1.0280195515422 0.109300942607826 no 465 0.151970315421471 744 443158
SGTC_182 3448-4371 550.524 µM 1.02588053700753 0.109729629185381 no 466 0.152473948903148 824 3491403
SGTC_1910 st062352 60.4 µM 1.02355757487463 0.110196546918093 no 467 0.153022146246614 755 2245730
SGTC_2443 5493264 126.67 µM 1.01995433967271 0.110923617586983 no 468 0.153875058147413 785 5340055
SGTC_354 2783-3500 4.88 µM 1.01988968158163 0.110936695784781 no 469 0.153890391866454 761 6740761
SGTC_3211 9128781 49.47 µM 1.01979880425193 0.110955079136339 no 470 0.153911945208734 738 17194361
SGTC_1498 4478-3555 97.6 µM 1.01547301150683 0.111832658527318 no 471 0.15494020257428 750 3437919
SGTC_2010 4012422 159 µM 1.01458719137917 0.112012976731937 no 472 0.155151323764152 788 952393
SGTC_781 4335-2806 94.4 µM 1.0135414340528 0.112226119311097 no 473 0.155400807785157 881 845254
SGTC_415 dibenzyl ketone 100 µM 1.01217826730224 0.11250439012746 no 474 0.155726412689109 805 7593
SGTC_2834 9001755 58.44 µM 1.01057105465251 0.112833112109386 no 475 0.156110887702039 720 2989575
SGTC_2670 beta-carotene 100 µM 1.00923916276591 0.11310604206388 no 476 0.156429974444435 731 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1309 pyrazolanthrone 13.4 µM 0.999157139224159 0.115187327662004 no 477 0.158859287513776 857 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_726 3448-4391 34.2 µM 0.997144742764626 0.115605996466873 no 478 0.159347128924474 845 1356692
SGTC_2541 muurolladie-3-one 83.07 µM 0.992317140162371 0.116614758824018 no 479 0.160521422344943 773 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2912 7964298 10.93 µM 0.991690756458814 0.116746102310268 no 480 0.160674200771316 848 2975850
SGTC_3291 9121177 71.43 µM 0.989877223286415 0.117126964939803 no 481 0.161117066778511 714 17015612
SGTC_872 0588-0139 234 µM 0.987471522086654 0.117633546785215 no 482 0.16170576850748 826 2047100
SGTC_1916 st067606 49.2 µM 0.986573714086381 0.117823000018773 no 483 0.161925830849473 850 19590279
SGTC_616 4092-0450 108 µM 0.984859262003294 0.11818537905531 no 484 0.162346603131435 849 787165
SGTC_3328 9140624 29.0385 µM 0.984151148801262 0.11833528075308 no 485 0.162520600501966 856 4904392
SGTC_880 0833-0487 87.2 µM 0.983390467496486 0.118496460379038 no 486 0.162707650032303 789 76075
SGTC_1856 st057054 55.7 µM 0.98132162160398 0.118935609692962 no 487 0.163217081814661 870 1266018
SGTC_198 3454-2873 16.191 µM 0.980900941104095 0.11902504703976 no 488 0.163320796677597 796 710957
SGTC_3353 9151644 39.2805 µM 0.97944619433264 0.119334694537871 no 489 0.163679780913405 818 4909158
SGTC_3215 9129942 49.47 µM 0.979027022391 0.119424022030667 no 490 0.163783313923148 781 17682944
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.977664858732503 0.11971463118254 no 491 0.164120053786587 780 6708514
SGTC_466 geldanamycin 89.2 µM 0.974917424921171 0.120302295611574 no 492 0.164800610970481 725 5288382 HSP90 inhibitor.
SGTC_1957 st077035 62.4 µM 0.974653849279632 0.120358779970295 no 493 0.164865996327785 849 705593
SGTC_2860 9025725 38.96 µM 0.974584671862047 0.120373607811188 no 494 0.164883159991751 777 40546248
SGTC_485 niflumic acid 177 µM 0.974232668374722 0.120449077967349 no 495 0.164970513781467 793 4488 A COX2 inhibitor.
SGTC_1016 4226-1401 38 µM 0.97348327063307 0.120609861116995 no 496 0.165156585403822 825 2901613
SGTC_2446 5162541 200 µM 0.972033922527633 0.120921247092345 no 497 0.165516836389276 784 1549321
SGTC_2636 apigenin dimethyl ether 100 µM 0.969745420495824 0.121414072609829 no 498 0.166086702149708 816 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3286 9117135 37.221 µM 0.968860826402386 0.121604946536834 no 499 0.166307316483384 776 3438150
SGTC_1720 st037298 9.481 µM 0.966381554200107 0.122141036813668 no 500 0.166926645335905 793 597396
SGTC_3190 9110366 49.47 µM 0.96569996422399 0.122288706623027 no 501 0.167097168706843 742 17123768
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.965502810683246 0.122331444262361 no 502 0.167146514438297 830 2724278 An inhibitor of dopamine biosynthesis.
SGTC_229 benomyl 22.8748 µM 0.965501358030783 0.122331759197646 no 503 0.16714687805881 825 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1168 k815-0004 80.5 µM 0.96545065586613 0.122342751791606 no 504 0.167159569884145 833 642433
SGTC_266 formosanin C 406 nM 0.964797925442502 0.122484330360135 no 505 0.167323017612324 834 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1978 st071761 42 µM 0.964481020298337 0.122553109178899 no 506 0.167402409747451 803 5147680
SGTC_1679 SEC14.276 6.7 µM 0.96004191828416 0.123519389068681 no 507 0.168517059180085 880 1005053 YMR079W SEC14
SGTC_2784 7567673 72.73 µM 0.959923337716211 0.12354527401975 no 508 0.168546899806619 871 3471247
SGTC_3342 9147791 14.508 µM 0.958574310649781 0.123840020602051 no 509 0.168886619629474 836 1838168
SGTC_1647 st011722 22.4 µM 0.958117281386998 0.123939987669044 no 510 0.169001811082717 809 2854783
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.957693632249548 0.124032703851431 no 511 0.169108634337124 862 229346 A bile salt which induces apoptosis.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.956337147850728 0.124329898727973 no 512 0.169450963884843 822 803109
SGTC_3007 9078383 71.4286 µM 0.955917478652832 0.124421945683386 no 513 0.169556963824355 847 6496995
SGTC_2745 rifampicin 24.3 µM 0.954633405806846 0.124703880082821 no 514 0.169881558772553 723 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_672 1441-0018 53.7 µM 0.953245168628591 0.125009187029063 no 515 0.170232932842348 802 251141
SGTC_74 000s-0487 160.283 µM 0.952401445634675 0.125194997020619 no 516 0.170446713296069 911 677548
SGTC_1908 st060353 56.5 µM 0.952130394771734 0.125254730457166 no 517 0.170515427969571 910 4227716
SGTC_711 k292-0785 179 µM 0.95037132356628 0.125642873305373 no 518 0.170961804833032 877 4146315
SGTC_1044 1222-0021 1.78 µM 0.949000614414097 0.125945904401381 no 519 0.171310149793148 833 4306703
SGTC_422 cantharidin 155 µM 0.947330425148817 0.126315831767173 no 520 0.171735215924542 833 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2696 st077691 74.316 µM 0.946666233294185 0.126463152703731 no 521 0.171904440992599 763 757133
SGTC_2345 9052315 157.45 µM 0.944069504066564 0.127040268311613 no 522 0.172567065963948 819 6469265
SGTC_1245 0418-0076 17.2 µM 0.943115567637455 0.127252737575461 no 523 0.172810896889942 852 6790114
SGTC_2053 5265679 138 µM 0.940962131887329 0.127733278601752 no 524 0.173362132717492 851 764595
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.940569846332157 0.127820953092547 no 525 0.173462670255933 935 368090
SGTC_1568 digitonin 820 nM 0.939763769432597 0.12800123978157 no 526 0.173669373424768 906 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.938460121428228 0.128293186678433 no 527 0.174004000802059 826 689007
SGTC_2375 9072683 200 µM 0.936137031527861 0.128814578988787 no 528 0.174601319355169 961 16798029
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.935811366605436 0.128887788253953 no 529 0.174685159053552 859 756377
SGTC_279 1273-0055 2.93 µM 0.935438393172621 0.128971667887546 no 530 0.174781209323485 935 2847562
SGTC_2002 4023503 131 µM 0.932908886382523 0.129541538771715 no 531 0.175433506895312 986 4736863 YCR052W RSC6
SGTC_2567 aureobasidin a 60 nM 0.932700316215544 0.129588605131498 no 532 0.175487360792457 832 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2828 7998861 71.43 µM 0.930283912668032 0.13013475927326 no 533 0.176112052482022 800 2988188
SGTC_1661 st013063 9.66 µM 0.929836016982748 0.130236167132649 no 534 0.176227997495448 938 721395
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.928869434022755 0.130455197019769 no 535 0.176478377641646 917 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1200 1643-0193 18.4 µM 0.928078378342824 0.130634641497571 no 536 0.176683457185582 930 5403974
SGTC_1838 st055369 84.5 µM 0.92513763725155 0.131303220493332 no 537 0.177447158769745 874 676036
SGTC_2617 dihydrotanshinone i 20.83 µM 0.924972409481302 0.131340855094576 no 538 0.177490129664324 913 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1709 st033179 39.1045 µM 0.923181579426221 0.13174923762197 no 539 0.177956293341349 891 573381
SGTC_1550 gossypolone 36.6 µM 0.921780324097659 0.132069391541866 no 540 0.178321586307463 931 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3020 9089140 49.47 µM 0.921467637662247 0.132140906198011 no 541 0.178403164907222 886 17217859
SGTC_1417 3966-0327 90.4 µM 0.921226663924479 0.132196037624512 no 542 0.178466049999941 935 651118
SGTC_500 h-89 112 µM 0.920132795206079 0.132446498875012 no 543 0.178751684165696 941 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.919524267355819 0.132585973922839 no 544 0.178910709238603 896 688667
SGTC_1234 0326-0494 15.5 µM 0.919057726891446 0.132692973856496 no 545 0.179032689379698 892 1547813
SGTC_1221 2958-7315 257 µM 0.918698874449343 0.13277531625965 no 546 0.179126549358024 846 4562705
SGTC_892 0929-0076 29 µM 0.918233923223938 0.132882056450341 no 547 0.179248206127031 906 5751038
SGTC_2251 lansoprazole 556 µM 0.917450256723751 0.133062098710969 no 548 0.179453373881531 735 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1693 xanthone 101.9 µM 0.916583556753563 0.133261412824682 no 549 0.179680452051644 922 7020 An insecticide.
SGTC_2716 st080858 38.6235 µM 0.911716659678412 0.134384463173354 no 550 0.180958945866047 942 5296050
SGTC_2887 9044784 58.44 µM 0.911161206787633 0.134513047460415 no 551 0.181105220337826 988 6465546
SGTC_997 3996-0078 137 µM 0.908335172318868 0.135168566727151 no 552 0.181850582545798 913 735687
SGTC_2614 arthonioic acid 13.39 µM 0.904648220321369 0.136027070085398 no 553 0.182825890378319 862 6710684
SGTC_262 fenpropimorph 62.5 µM 0.90448033244357 0.136066251278583 no 554 0.182870379271388 845 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3097 9117246 49.47 µM 0.903493430084205 0.136296727903082 no 555 0.183132036779194 913 16423892
SGTC_2486 5283202 22.39 µM 0.903446086889976 0.136307790924566 no 556 0.183144594751916 839 1377751
SGTC_2984 9022109 38.96 µM 0.90259752738568 0.136506184066943 no 557 0.183369769662416 902 6459207
SGTC_546 peri-Naphthalide 147 µM 0.901286332759612 0.136813129456804 no 558 0.183718049316157 907 223824 A penicillin ester.
SGTC_89 0302-0250 142.109 µM 0.90090619883609 0.136902205428126 no 559 0.18381909753796 987 4203518 YLR208W SEC13
SGTC_630 4356-0227 183 µM 0.899339891487599 0.137269652966879 no 560 0.184235822657997 879 779312
SGTC_324 1315-0088 19.6 µM 0.898665579111965 0.137428050360047 no 561 0.184415408257732 854 6787421
SGTC_641 4092-0595 30 µM 0.894794922616054 0.138339689463195 no 562 0.185448362510085 931 786260
SGTC_1852 st056254 31.4 µM 0.893913802638321 0.138547790533023 no 563 0.185684006087347 902 442583
SGTC_2212 7123476 200 µM 0.893459500754736 0.13865516989567 no 564 0.185805575508635 858 1085715
SGTC_1625 st003711 30.1 µM 0.892626506207882 0.138852204774619 no 565 0.186028609827006 923 24207034 YER133W GLC7
SGTC_1060 3448-7350 82 µM 0.892481139754076 0.138886608998079 no 566 0.186067548702633 901 570178
SGTC_948 3448-0295 75.3 µM 0.891302595786364 0.139165752089574 no 567 0.186383428240915 947 678569
SGTC_1315 1237-0019 3.69 µM 0.89101877847319 0.139233032421673 no 568 0.18645954805109 960 825140
SGTC_3258 9138477 49.47 µM 0.888432948232174 0.139847036058376 no 569 0.187153954371004 930 4970355
SGTC_1035 k081-0041 55.2 µM 0.888315505857376 0.139874966295729 no 570 0.187185530608795 970 731709
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.884811257358581 0.140710093938525 no 571 0.18812921842723 770 6708630 An antioxidant.
SGTC_2055 5235184 200 µM 0.882775119346364 0.141196894666083 no 572 0.188678892985261 902 2836034
SGTC_1885 st057546 99.9 µM 0.878016692440085 0.142338989329239 no 573 0.189967330056062 975 702008
SGTC_2298 7976326 193.81 µM 0.876525327706914 0.14269822231594 no 574 0.190372256787585 869 2235818
SGTC_1991 st073000 8.92 µM 0.876413855152033 0.142725097903913 no 575 0.190402544448843 975 4301969 YIL048W NEO1
SGTC_353 1988-1175 58.3 µM 0.871336410289916 0.143952877922651 no 576 0.191785247746405 887 2788357
SGTC_964 1287-0107 19.4 µM 0.87005855293524 0.144262996126141 no 577 0.192134203247743 958 51516812 YPR165W RHO1
SGTC_2970 9090938 41.86 µM 0.868866276071687 0.144552750972424 no 578 0.192460138613108 998 17217104
SGTC_86 0417-1630 471.922 µM 0.86782829212784 0.144805327608438 no 579 0.192744169658828 1049 3634867
SGTC_1502 4534-4282 27.7 µM 0.865780717789235 0.145304442668801 no 580 0.193305212641494 919 3278949
SGTC_2017 5132927 60.65 µM 0.865755850810603 0.145310511328193 no 581 0.193312032405511 971 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3248 9135562 49.47 µM 0.864657667787308 0.145578687348152 no 582 0.193613355285872 974 17650701
SGTC_688 0527-0193 473 µM 0.861296238112024 0.146401614917297 no 583 0.194537453535733 915 4007154
SGTC_1702 st027038 51 µM 0.859478533970731 0.146847914259323 no 584 0.195038279030685 974 5521182
SGTC_2360 9040895 200 µM 0.859339736184198 0.146882030626092 no 585 0.195076553670714 895 4914414
SGTC_665 3914-0008 307 µM 0.857959014952978 0.147221700104859 no 586 0.195457547562824 947 1069549
SGTC_2414 st077232 92.9 µM 0.857120071902399 0.147428344382421 no 587 0.195689264667491 881 729801
SGTC_2260 7964312 200 µM 0.855950972735412 0.147716635054705 no 588 0.19601244927157 900 231951
SGTC_383 2324-0395 7.37 µM 0.85528252686213 0.147881638084535 no 589 0.196197379179344 985 3146421
SGTC_468 gf-109203x 121 µM 0.853904855012593 0.148222099636045 no 590 0.196578854647527 875 2396 A protein kinase C inhibitor.
SGTC_870 0573-2213 57.6 µM 0.852806225928542 0.148493977412508 no 591 0.196883385379537 998 3916321
SGTC_2648 atorvastatin 78.68 µM 0.849915353205861 0.149210974141998 no 592 0.197686074498623 966 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_129 0088-0017 176.636 µM 0.849075202053793 0.149419782002744 no 593 0.197919724006718 939 182446
SGTC_1624 st003710 6.25 µM 0.847194023710912 0.149888029686159 no 594 0.198443492040264 1028 24207033
SGTC_64 000l-0018 272.079 µM 0.842689413478759 0.151013254309659 no 595 0.199701084742048 1011 6811119
SGTC_2041 5107442 45.335 µM 0.839106251854098 0.151912310665376 no 596 0.200704844064317 998 793005
SGTC_2861 9024595 19.48 µM 0.837919804773276 0.152210785881468 no 597 0.201037872498363 942 16482810
SGTC_1763 st044482 94.5 µM 0.837726687838414 0.152259405247947 no 598 0.201092110589811 996 88505
SGTC_2444 5485484 36.41 µM 0.837404159738518 0.152340628321166 no 599 0.201182714177352 1023 6790631
SGTC_1694 st024011 44.9 µM 0.836866254575384 0.152476154319974 no 600 0.201333875261943 1045 2787533
SGTC_1304 1165-0502 251 µM 0.835119854608071 0.152916713780901 no 601 0.201825114384905 999 767425
SGTC_622 1348-1566 26.3 µM 0.83184904249167 0.15374410095825 no 602 0.202747078917036 1047 7340407
SGTC_3200 9114385 49.47 µM 0.830942241369145 0.153974009799871 no 603 0.203003129561804 960 17018030 YLR208W SEC13
SGTC_2705 st078069 42.8 µM 0.830685245721231 0.154039209398808 no 604 0.203075731736674 931 1530061
SGTC_1400 3771-8998 51.5 µM 0.829409894034789 0.154363035348683 no 605 0.203436252378386 958 670767
SGTC_2467 5474540 200 µM 0.829111736276082 0.154438805781317 no 606 0.20352059163667 1010 5413519
SGTC_2411 st077133 39.94 µM 0.828072287878101 0.15470315166078 no 607 0.203814781265759 1038 1403142 YNL221C POP1
SGTC_2080 5212524 12.4 µM 0.827437999666306 0.154864606584607 no 608 0.203994424996589 983 260183
SGTC_1273 0849-0096 14.1 µM 0.826155752135932 0.155191336160536 no 609 0.204357872406089 978 5286025
SGTC_3130 9127414 49.47 µM 0.822071524293845 0.156235069478651 no 610 0.205518095474698 1018 1494646
SGTC_2897 9048598 12.99 µM 0.821594795963524 0.15635719913919 no 611 0.205653776046002 998 6467404
SGTC_556 4058-0063 51.5 µM 0.821349036191977 0.15642018315375 no 612 0.205723741942602 1051 6615692
SGTC_2252 omeprazole 400 µM 0.821227278906298 0.156451393646503 no 613 0.205758410527731 931 4594 A proton pump inhibitor.
SGTC_207 4185-0010 4.486 µM 0.82099682490874 0.156510477992739 no 614 0.205824038383139 1090 3761753
SGTC_2766 oltipraz 83.91 µM 0.818306252963958 0.157201380207486 no 615 0.206591168256955 981 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2225 6654152 15.4 µM 0.81764669972591 0.157371050090025 no 616 0.206779476723296 970 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2899 9053889 58.44 µM 0.816538944978279 0.157656290455091 no 617 0.207095979370497 1010 6470052
SGTC_1361 1608-0041 5.61 µM 0.81565599929302 0.157883886905797 no 618 0.207348455725568 1015 X1361
SGTC_1232 0279-0259 161 µM 0.814194283303859 0.158261146699208 no 619 0.207766829949056 1001 1560000
SGTC_150 3970-0969 77.2 µM 0.813640738523156 0.158404167451065 no 620 0.207925396321411 1019 6615640
SGTC_3293 9120939 62.045 µM 0.813561223255925 0.158424718972202 no 621 0.207948179836055 991 934087
SGTC_105 0111-0055 734.78 µM 0.810202013068497 0.159294538349973 no 622 0.208912040348629 925 5179370
SGTC_2822 7994718 71.43 µM 0.810177500644906 0.159300896963071 no 623 0.208919083374014 939 1018011
SGTC_1340 1486-1359 257 µM 0.809399169763048 0.159502885292069 no 624 0.209142789804917 1026 4309068
SGTC_1416 3966-0321 25.3 µM 0.805623150471699 0.160485196460434 no 625 0.210230086457585 1067 582530 YLR208W SEC13
SGTC_1911 st060208 74.3 µM 0.80154464744413 0.161550627655454 no 626 0.211408203804936 1056 688783
SGTC_1429 4049-0205 9.46 µM 0.800318342363402 0.161871876142672 no 627 0.211763189233546 1072 22774478
SGTC_226 1,3-diallylurea 8.28947 mM 0.80021634681646 0.161898614098111 no 628 0.211792730162092 1008 74537 YKL182W FAS1
SGTC_2942 9052777 62.25 µM 0.799855770422795 0.161993161638511 no 629 0.211897183084005 1091 6469503
SGTC_1712 st032288 53.4 µM 0.796447794661451 0.162888550529716 no 630 0.212885903831007 1087 2883011
SGTC_785 1270-0111 65.3 µM 0.789040382791908 0.164845801396325 no 631 0.215044202213081 1079 6741994
SGTC_165 k038-0023 64.381 µM 0.78785530928686 0.165160339469248 no 632 0.215390672312906 1094 46368543
SGTC_762 1165-0429 115 µM 0.785581466966862 0.165764941791184 no 633 0.216056362784491 1060 5967793
SGTC_1326 1431-2094 10.8 µM 0.784930149236597 0.165938386936376 no 634 0.216247262016173 1054 616278
SGTC_2630 antimycin a 100 µM 0.784265186582386 0.166115586662405 no 635 0.2164422612422 1119 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_151 3013-0144 2.285 µM 0.782506012848154 0.166584961807302 no 636 0.216958626524608 1035 906558 YHR107C CDC12
SGTC_2738 aclarubicin 5.55 µM 0.782301966503431 0.166639459922331 no 637 0.217018565718466 978 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3312 9133330 71.43 µM 0.780546086739043 0.167108907946811 no 638 0.217534755743176 1106 17617324
SGTC_2934 9036370 36.88 µM 0.780202163984029 0.167200958122161 no 639 0.217635944399598 1088 6462800
SGTC_2938 9059746 27.26 µM 0.778853686808701 0.167562190354741 no 640 0.218032954118123 1001 6471769
SGTC_1130 3454-2858 15.9 µM 0.777833017204319 0.167835942982983 no 641 0.218333730306708 995 715628 YIL048W NEO1
SGTC_900 1112-0045 141 µM 0.776671455132314 0.168147834317785 no 642 0.21867631603133 981 56211 YIL048W NEO1
SGTC_2171 5739187 198.077 µM 0.775002589281382 0.168596594263492 no 643 0.21916906478742 1049 2262761
SGTC_2126 5251174 33.877 µM 0.773994503458044 0.168868042341902 no 644 0.219467020850974 1132 790722
SGTC_3133 9127736 49.47 µM 0.761760814715349 0.172184576454174 no 645 0.223101385747043 1106 27243420
SGTC_302 1094-0063 18.9 µM 0.76055159441195 0.172514636677282 no 646 0.223462470647076 1049 5440289
SGTC_2128 5255449 168.493 µM 0.759819796618006 0.172714578873796 no 647 0.223681153943819 1133 736008
SGTC_2332 7982454 138.89 µM 0.759505817583275 0.172800409666805 no 648 0.223775017658848 1074 2981748
SGTC_230 MPP+ 141.667 µM 0.759110580943701 0.172908492064995 no 649 0.223893205078473 1074 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1049 3226-0134 66 µM 0.756862552295375 0.173524062650349 no 650 0.224566106279113 1152 5702385
SGTC_3155 9099265 49.47 µM 0.756233872514125 0.173696461300329 no 651 0.224754493757338 1012 25236499
SGTC_1752 st044819 83.042 µM 0.754674422902632 0.174124568920542 no 652 0.225222178369684 1082 441209 YML126C ERG13
SGTC_1963 st076565 50.3 µM 0.754305111434244 0.174226052224469 no 653 0.225333016897266 1125 4914280
SGTC_1364 1653-0028 37.6 µM 0.754241068164019 0.174243654533775 no 654 0.225352240839084 1063 5718652
SGTC_1235 benzylparaben 21.5 µM 0.752966706614409 0.174594148087902 no 655 0.225734960442382 1076 7180
SGTC_179 1273-0063 6.77 µM 0.752107017324996 0.174830845111104 no 656 0.225993352134906 1089 3108139
SGTC_2346 9031566 143.75 µM 0.752074107277424 0.174839910233211 no 657 0.226003247033871 1083 4771086
SGTC_2064 5220758 200 µM 0.751882557877504 0.174892678724755 no 658 0.226060844092341 1146 788518
SGTC_3336 9143619 71.43 µM 0.746784818453493 0.176300728688991 no 659 0.22759673052536 1146 45595730
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.746696862238379 0.176325085915146 no 660 0.227623282116092 1143 688664
SGTC_2789 5281112 71.43 µM 0.746338732161344 0.176424282871947 no 661 0.227731409857364 1104 765948
SGTC_642 0335-0876 158 µM 0.74616395429091 0.17647270668185 no 662 0.227784189828725 1125 6812350
SGTC_756 0508-1999 28.3 µM 0.745664871129228 0.176611028517972 no 663 0.227934942423092 1123 6753853
SGTC_1619 st003326 88.7 µM 0.744599773438638 0.176906451556405 no 664 0.228256852473225 1104 2849032
SGTC_1676 st018489 23.4 µM 0.744128118970335 0.17703737269059 no 665 0.228399484671846 1078 3696235
SGTC_3173 9105693 49.47 µM 0.741535291768558 0.17775817855996 no 666 0.22918447077375 1178 17096658
SGTC_766 1391-0721 126 µM 0.741133147119987 0.177870140375954 no 667 0.229306356641608 1133 1020919 YIL115C NUP159
SGTC_3356 9151811 4.48 µM 0.740987205472582 0.177910783250149 no 668 0.229350599025467 1091 1859254 YPR165W RHO1
SGTC_2662 daunorubicin 22.37 µM 0.740877773484689 0.17794126249516 no 669 0.229383776601623 1095 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2117 5521686 200 µM 0.740354081283473 0.178087168013817 no 670 0.229542586772509 1122 803312
SGTC_3289 9119912 71.43 µM 0.736394840059728 0.179192688826349 no 671 0.23074522196684 1150 17014829
SGTC_3186 9110464 49.47 µM 0.735495248398408 0.179444478233089 no 672 0.231018966373327 1123 17018021
SGTC_1907 st060210 83.7 µM 0.734766926489826 0.179648493280477 no 673 0.231240726376732 1167 688793
SGTC_1872 amphotericin b 148 nM 0.733378496653988 0.180037819090659 no 674 0.23166380533743 1153 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1015 4130-4525 82 µM 0.725561224825399 0.182239714739062 no 675 0.234053899489349 1153 1363237
SGTC_1674 st016616 23.6 µM 0.724940408148469 0.182415298978826 no 676 0.234244294880875 1154 625830
SGTC_2652 actinonin 100 µM 0.722394855764069 0.183136356632952 no 677 0.23502587437903 1140 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1997 st073024 93.8 µM 0.722183593615357 0.183196278916347 no 678 0.235090804418677 1150 686268
SGTC_3224 9130643 49.47 µM 0.719297110410203 0.184016224042713 no 679 0.235978937971083 1186 17644395
SGTC_362 0310-0100 9.03 µM 0.719106402855138 0.184070477487959 no 680 0.236037681265683 1166 790235
SGTC_2043 5101342 149 µM 0.715700156666481 0.185041180271956 no 681 0.237088257028858 1168 678451
SGTC_1072 oxiconazole 14.9 nM 0.715177179245156 0.185190498083465 no 682 0.237249784222327 1156 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1721 st082152 9.2685 µM 0.713829513869887 0.185575621291219 no 683 0.237666303579511 1145 5296051
SGTC_467 ro 31-8220 72.8 µM 0.713421148847547 0.18569241807577 no 684 0.237792595031093 1130 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_308 4092-1169 104 µM 0.712959316354206 0.185824562070629 no 685 0.237935466236839 1155 2268590 YDL196W YDL196W
SGTC_157 1348-1695 65.819 µM 0.710912523332698 0.186410912109571 no 686 0.238569222521317 1183 5380510
SGTC_2133 5320837 200 µM 0.709655563333761 0.186771564037421 no 687 0.238958877278279 1137 2841355
SGTC_797 k781-0471 270 µM 0.708862892615302 0.186999222154826 no 688 0.239204782215631 1175 23738129
SGTC_94 0334-0113 514.748 µM 0.708216149482813 0.187185096421846 no 689 0.239405519404448 1145 6795178
SGTC_2322 7413319 38.22 µM 0.705700640455105 0.187909140711156 no 690 0.24018716130467 1198 1840400
SGTC_970 1315-0089 19.5 µM 0.70500901531666 0.188108515328645 no 691 0.240402312892973 1143 6811083 YLR033W RSC58
SGTC_84 0443-0269 128.823 µM 0.704531735710681 0.188246176716143 no 692 0.240550846807991 1147 6150058
SGTC_1129 3453-1384 223 µM 0.703257083674521 0.188614128186425 no 693 0.240947775350248 1235 1084452
SGTC_1831 st055328 12 µM 0.702516706641286 0.18882805490014 no 694 0.2411784933126 1185 1103068
SGTC_185 k048-0037 25.491 µM 0.702174541535328 0.188926971588134 no 695 0.241285160134561 1205 6827589
SGTC_514 4466-0038 2.65 nM 0.701181646223859 0.18921418889065 no 696 0.241594831184297 1151 5722064
SGTC_1994 st072947 40.9 µM 0.701083588052304 0.189242569001986 no 697 0.241625425948292 1190 5286565 YDL195W SEC31
SGTC_609 0986-0026 86.3 µM 0.70072185832719 0.189347283908552 no 698 0.241738306079239 1173 2848610
SGTC_1695 st026914 34.495 µM 0.698830729065329 0.189895315693757 no 699 0.242328911048276 1153 3289191
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.698143734529081 0.190094641598732 no 700 0.242543654826736 1196 5282362
SGTC_2732 terfenadine 20 µM 0.696982811426826 0.190431766134729 no 701 0.242906775395149 1182 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2406 ethylparaben 405.7 µM 0.692910655298595 0.191617193688142 no 702 0.244182811205234 1112 8434 A possible steroid mimic.
SGTC_3121 9125696 49.47 µM 0.692579092015522 0.191713912209525 no 703 0.244286867539174 1257 1235365
SGTC_191 3914-0123 66.505 µM 0.690665882572547 0.192272587876922 no 704 0.24488776722125 1133 3144412
SGTC_106 0092-0003 11.579 µM 0.686916896655087 0.19337021160674 no 705 0.246067549310398 1170 1072148
SGTC_1733 st037357 54.9 µM 0.685550161766504 0.193771311758154 no 706 0.246498409253186 1184 1272339 YGL099W LSG1
SGTC_541 4513-1321 94 µM 0.684873551228492 0.193970066423721 no 707 0.246711858619348 1175 747515
SGTC_73 0327-0325 16.231 µM 0.684448811642372 0.194094897323202 no 708 0.246845901162893 1244 53298
SGTC_307 1501-1223 22.3 µM 0.680865490404664 0.195149981838012 no 709 0.247978302979617 1210 2830329
SGTC_2200 6600604 21.907 µM 0.680700783926384 0.195198562185684 no 710 0.248030420104978 1188 2904777
SGTC_2710 st078562 53.7235 µM 0.679074955619224 0.195678496167947 no 711 0.248545185031044 1196 17250908
SGTC_1529 apigenin 74 µM 0.675221154761391 0.196818971183227 no 712 0.249767634105362 1284 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_482 fipronil 114 µM 0.674312533637065 0.197088449301848 no 713 0.25005631863629 1254 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1658 st012944 20 µM 0.669665170723599 0.198470248685495 no 714 0.25153562959048 1186 24207260
SGTC_3273 9137859 49.47 µM 0.669289886556997 0.19858208631092 no 715 0.251655288455095 1299 2377234
SGTC_1746 st038117 42 µM 0.667164651326547 0.19921613989827 no 716 0.252333483750696 1246 2898218
SGTC_2658 polymyxin b sulfate 77.05 µM 0.665464817385002 0.199724153674113 no 717 0.2528766196595 1210 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1262 0737-0114 49.6 µM 0.663635657260474 0.200271687651861 no 718 0.25346176488909 1276 765919
SGTC_1883 5-benzylidenerhodanine 20 µM 0.662264580517353 0.200682691447914 no 719 0.25390083611549 1237 1273210
SGTC_2983 9022671 12.99 µM 0.660982745686151 0.201067401065344 no 720 0.254311689443594 1261 6405161
SGTC_2210 7115885 190.385 µM 0.660240108741494 0.201290486595328 no 721 0.254549878572147 1263 2927039
SGTC_2888 9058547 12.99 µM 0.659079064563251 0.201639557374792 no 722 0.254922499298461 1188 16476514
SGTC_85 0868-0259 160.055 µM 0.657966203321238 0.201974481955376 no 723 0.255279924130901 1213 83173
SGTC_2664 lyso-paf C-16 73.48 µM 0.657601438052873 0.202084333427745 no 724 0.255397135131278 1259 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3270 9137563 49.47 µM 0.656984387009492 0.202270243806648 no 725 0.255595477806984 1228 17015724
SGTC_3194 9111903 49.47 µM 0.654162824875388 0.203121650602943 no 726 0.256503454636446 1282 17087251
SGTC_3073 9114972 49.47 µM 0.653677868985496 0.203268201286667 no 727 0.25665968216941 1202 41905075
SGTC_154 3389-1638 511.116 µM 0.652871591986147 0.203511992855956 no 728 0.256919532254688 1172 5238686
SGTC_1571 st070080 73.4 µM 0.651507057775217 0.203924980115335 no 729 0.257359611307581 1312 4315245
SGTC_838 0109-0203 71.4 µM 0.649834879024853 0.204431758894879 no 730 0.257899443178591 1265 759422
SGTC_1052 3253-3998 198 µM 0.649716237822912 0.204467743342892 no 731 0.257937766597039 1253 5450317
SGTC_2840 9008771 71.43 µM 0.643937703497586 0.206224960109757 no 732 0.259807915708051 1254 2992978
SGTC_1870 st057514 26.5 µM 0.643886692780401 0.206240511909871 no 733 0.259824455775356 1279 5393161
SGTC_3214 9129694 49.47 µM 0.64371199278928 0.206293778520648 no 734 0.259881105823395 1242 17158655
SGTC_1156 4092-0367 4.88 µM 0.64306344335123 0.206491594719104 no 735 0.260091466973065 1270 1357585
SGTC_2835 9006588 71.43 µM 0.642290231760898 0.206727581319875 no 736 0.260342377756312 1283 2345538
SGTC_1747 st037496 66.6 µM 0.641954996311656 0.206829945834469 no 737 0.260451201969443 1307 723305
SGTC_2005 4024620 188 µM 0.641875086079049 0.206854350940024 no 738 0.260477145905876 1283 236743
SGTC_884 0851-0618 334 µM 0.641193533383622 0.20706257082966 no 739 0.260698475261924 1262 9642473
SGTC_2806 7952793 58.44 µM 0.640606820110661 0.207241915785763 no 740 0.260889083684267 1303 2972490
SGTC_1920 st075728 45.7 µM 0.640441780419957 0.207292381230593 no 741 0.260942713853642 1332 3400306
SGTC_2460 5552655 174.22 µM 0.640094485961247 0.207398599837006 no 742 0.261055586801049 1260 5401989
SGTC_776 4476-4378 112 µM 0.640021244600469 0.207421004518794 no 743 0.261079393921882 1275 2892008
SGTC_1296 1068-0102 11.9 µM 0.63812124308286 0.208002718688649 no 744 0.261697379619609 1258 767053
SGTC_2962 9082311 13.18 µM 0.637691575221934 0.208134401396428 no 745 0.261837235387552 1263 16459453
SGTC_709 3807-1509 243 µM 0.636644195512291 0.208455603771377 no 746 0.26217831529827 1323 1886677 YPL242C IQG1
SGTC_3003 9075612 71.4286 µM 0.63654597559814 0.208485740085766 no 747 0.262210312351169 1284 6501993
SGTC_245 methotrexate 289.6 µM 0.633902248358196 0.20929786621269 no 748 0.263072309092776 1293 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3023 9089636 49.47 µM 0.632103544490675 0.209851472538482 no 749 0.263659609621901 1353 17249241
SGTC_2508 celastrol 40.54 µM 0.631435788547428 0.210057213812839 no 750 0.263877810861023 1246 122724 Celastrol is a natural product and antioxidant.
SGTC_1137 ixabepilone 100 µM 0.631201259842367 0.21012950220927 no 751 0.263954469163484 1297 154225 A novel microtubule stabilizer.
SGTC_3207 9114163 49.47 µM 0.631006759888177 0.21018946369329 no 752 0.264018052234615 1367 849233
SGTC_41 0478-0632 82.643 µM 0.630690468184529 0.210286993244144 no 753 0.26412146634098 1285 3750424
SGTC_1487 3970-0795 2.82 µM 0.62861647668297 0.210927173225204 no 754 0.264800085375823 1328 3765103
SGTC_1992 st073643 23.3 µM 0.628301975472821 0.211024350149474 no 755 0.264903068886909 1282 3161292
SGTC_1204 4049-0315 18.3 µM 0.627308185705041 0.211331591144542 no 756 0.265228619360791 1387 588402
SGTC_2395 5646831 180.19 µM 0.627290718416954 0.211336993690257 no 757 0.265234343195847 1343 6808628
SGTC_175 3793-3120 23.7 µM 0.627029629602023 0.211417756809637 no 758 0.265319906556321 1297 5322297
SGTC_455 paf C-16 10 µM 0.625006369793906 0.212044228270109 no 759 0.265983438735124 1277 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2727 riluzole 51.77 µM 0.624895074772681 0.212078720542579 no 760 0.266019962541892 1306 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_476 mead acid 10 µM 0.62376597990384 0.212428832212294 no 761 0.26639064238016 1324 5312531 An omega 9 fatty acid.
SGTC_1562 morin hydrate 59.1 µM 0.622351133404065 0.21286802659082 no 762 0.266855502599452 1332 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_272 doxorubicin 8.13 µM 0.621324363474241 0.21318708646126 no 763 0.267193113317639 1306 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3278 9139605 49.47 µM 0.620035945121151 0.213587845625449 no 764 0.267617061043484 1338 7958859
SGTC_2328 6201408 200 µM 0.617811900583783 0.214280660738606 no 765 0.268349668925662 1288 2890418
SGTC_2485 5633444 17.78 µM 0.617782699172573 0.214289765995694 no 766 0.268359294675209 1287 5724239
SGTC_871 0574-0004 149 µM 0.616546827351968 0.214675327984552 no 767 0.268766837974317 1325 9551173
SGTC_345 1362-0200 395 µM 0.615847498177837 0.214893680193511 no 768 0.268997587665565 1291 1419823
SGTC_1940 st075990 51.1 µM 0.614834308196995 0.215210258188822 no 769 0.269332074746265 1407 1084979
SGTC_803 4488-1585 147 µM 0.612877158543424 0.215822548575613 no 770 0.269978783711897 1283 747204
SGTC_2971 9092186 9.93 µM 0.612660437517924 0.215890411351379 no 771 0.270050443488565 1248 25236400
SGTC_3161 9100388 49.47 µM 0.611641432538851 0.216209662420056 no 772 0.270387509562277 1357 25236368
SGTC_3080 9117754 49.47 µM 0.611098323380352 0.216379928431053 no 773 0.270567244864169 1433 9550191
SGTC_3262 9137218 49.47 µM 0.608839371869087 0.217088947255724 no 774 0.271315456884383 1204 17650664
SGTC_2544 sphondin 68.51 µM 0.608697879680554 0.217133402145817 no 775 0.271362356353563 1367 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2181 6316240 54.2555 µM 0.60687811159401 0.217705616752659 no 776 0.271965902560742 1307 12779990
SGTC_817 1391-0715 46 µM 0.605552497235673 0.218122994988407 no 777 0.272405977144223 1289 1353946
SGTC_3330 9141424 71.43 µM 0.605276846189991 0.218209843385426 no 778 0.272497531581746 1357 27261020
SGTC_1006 4099-6547 255 µM 0.604989665196567 0.218300345672608 no 779 0.272592931812012 1355 3146833
SGTC_1666 st014829 29 µM 0.603799141812194 0.218675758062454 no 780 0.272988595049882 1347 3858230
SGTC_2046 4110841 106 µM 0.603161714489758 0.218876913159978 no 781 0.273200557133743 1344 44119630 YMR134W ERG29
SGTC_99 0109-0120 622.8 µM 0.602815115963717 0.21898633509435 no 782 0.27331584487184 1384 759414
SGTC_1449 4112-4002 201 µM 0.602541118964228 0.219072858826446 no 783 0.27340700049256 1275 2059539
SGTC_600 1495-0418 41.6 µM 0.600489743532252 0.219721273587303 no 784 0.274089947137243 1339 5377768
SGTC_1840 st055363 71 µM 0.599973612556649 0.219884589619655 no 785 0.274261910765012 1277 676033
SGTC_2331 7980721 200 µM 0.599940019785815 0.219895221580029 no 786 0.274273104992764 1336 2981221
SGTC_799 1310-0557 151 µM 0.59935817671554 0.220079419089328 no 787 0.274467030230039 1365 5354492
SGTC_288 1315-0019 35.1 µM 0.595269015559311 0.221376443376218 no 788 0.275831831878142 1373 6811474
SGTC_3208 9114115 49.47 µM 0.594774257349919 0.221533669584433 no 789 0.275997188628562 1293 650895
SGTC_635 k038-0028 24.7 µM 0.594522183882432 0.221613799019204 no 790 0.276081454656575 1393 4035102
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.594059341939661 0.221760970924283 no 791 0.276236211684476 1332 15053
SGTC_1811 st050069 61.5 µM 0.59346821345832 0.221949015836639 no 792 0.276433924813306 1335 3877702
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.590937381259879 0.222755131922254 no 793 0.277281189103357 1395 6708739 YPR165W RHO1
SGTC_1382 3002-2117 298 µM 0.58977588318296 0.223125648051962 no 794 0.277670456635329 1413 1497314
SGTC_806 3966-4455 5.86 µM 0.589587037443097 0.223185922703565 no 795 0.277733772115018 1290 714982
SGTC_2380 9035439 200 µM 0.585726589146455 0.224420107257485 no 796 0.279029631523494 1425 6462575
SGTC_532 1548-0774 215 µM 0.585028560936766 0.224643679517925 no 797 0.279264256294227 1473 5932993
SGTC_3033 9090887 49.47 µM 0.584232394959911 0.224898838596873 no 798 0.279531984612698 1319 19325384
SGTC_615 k087-0205 167 µM 0.582569425605283 0.225432324569557 no 799 0.280091596301853 1304 9642773
SGTC_2988 9073640 71.4286 µM 0.582569129458125 0.225432419638286 no 800 0.280091696007715 1412 9102229
SGTC_886 0866-0150 153 µM 0.582083530928432 0.225588336298004 no 801 0.280255208876403 1419 271463
SGTC_3149 9097855 49.47 µM 0.581217060183771 0.22586669547865 no 802 0.280547085519794 1432 25236625 YMR079W SEC14
SGTC_8 0354-0001 70 µM 0.581151189722307 0.225887864720395 no 803 0.280569280454167 1406 4993152
SGTC_1251 0490-5699 265 µM 0.58036540541042 0.226140484116876 no 804 0.280834114580612 1403 3883818
SGTC_1651 st011928 86.1 µM 0.580293373473903 0.226163649429683 no 805 0.280858397663973 1375 720198
SGTC_1945 st075991 56.6 µM 0.578404154090969 0.22677169683012 no 806 0.281495645005068 1288 1084980
SGTC_3205 9113483 49.47 µM 0.57749614911944 0.227064267132259 no 807 0.281802169634408 1426 17018033
SGTC_1685 st024049 53.0905 µM 0.577200311710934 0.227159635506238 no 808 0.281902073260539 1353 1941139
SGTC_2965 9082772 38.63 µM 0.575037145532496 0.227857655766935 no 809 0.282633087685368 1427 16459634
SGTC_343 4130-2827 29.8 µM 0.574824758103255 0.227926254910382 no 810 0.282704910398801 1370 1118244
SGTC_511 blebbistatin 171 µM 0.574398956921579 0.228063819681039 no 811 0.282848929306725 1441 3476986 A myosin inhibitor.
SGTC_3210 9128157 49.47 µM 0.571816629687442 0.228899098877906 no 812 0.283723104940025 1370 17590849
SGTC_1457 k015-0032 57.3 µM 0.570376575565357 0.229365643225467 no 813 0.284211156824306 1377 4302660
SGTC_1236 0330-0013 258 µM 0.569967856268075 0.229498155905432 no 814 0.284349749867197 1366 4617066
SGTC_3063 1327-0034 4 µM 0.568523618259888 0.229966742111591 no 815 0.284839736536307 1300 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3303 9125618 40.5795 µM 0.568395514721193 0.230008331426651 no 816 0.28488321767105 1466 22695467
SGTC_3184 9108758 49.47 µM 0.566247615506936 0.230706281936229 no 817 0.285612732715788 1391 902885
SGTC_2582 agaric acid 100 µM 0.565101504996215 0.231079189117086 no 818 0.286002362454339 1286 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3011 9081274 71.4286 µM 0.564048446970736 0.231422116374917 no 819 0.28636058076222 1373 6625322
SGTC_1351 1496-0003 46.5 µM 0.563902301536319 0.231469730898971 no 820 0.286410311818204 1383 3891978
SGTC_137 0438-0332 85.389 µM 0.56090189350034 0.232448477145791 no 821 0.287432209572546 1373 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1473 k844-0725 134 µM 0.560137274179324 0.232698266828 no 822 0.287692903867868 1430 54682906
SGTC_214 4373-3496 70 µM 0.559521613250639 0.232899502409862 no 823 0.287902892484863 1453 3779166
SGTC_1212 0520-0165 585 µM 0.559362316216209 0.232951586145164 no 824 0.287957237039105 1599 5403258
SGTC_3036 9090181 49.47 µM 0.558894858245247 0.233104463476797 no 825 0.288116739366671 1422 25236586
SGTC_3318 9139014 38.6185 µM 0.557490468047863 0.233564089767812 no 826 0.288596184925242 1404 16643984
SGTC_3299 9121982 43.1275 µM 0.556838693130234 0.233777572114611 no 827 0.288818822350738 1404 17594604 YPL160W CDC60
SGTC_2348 9022543 33.42 µM 0.556263234750017 0.233966147604542 no 828 0.289015458266552 1428 3162678 YDL140C RPO21
SGTC_506 n9-isopropylolomoucine 153 µM 0.555746101540334 0.234135682025505 no 829 0.289192217998517 1450 6610355
SGTC_340 k038-0059 454 µM 0.555202009246231 0.234314127992899 no 830 0.289378247381804 1425 23733424
SGTC_2001 4023502 57.655 µM 0.553601755359797 0.234839399327047 no 831 0.289925712223748 1443 108941 YCR052W RSC6
SGTC_124 0136-0217 7.121 µM 0.55311098662879 0.235000620793748 no 832 0.290093706989676 1513 3976905
SGTC_2769 toremifene 3.73 µM 0.552214070007253 0.2352954230401 no 833 0.29040084783243 1427 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1851 st056236 18.9 µM 0.551197389149987 0.235629836624214 no 834 0.290749184821152 1440 5393171
SGTC_2243 6634756 200 µM 0.551099080684673 0.235662186808197 no 835 0.290782877798174 1491 885676
SGTC_2504 purpurogallin 52.29 µM 0.550895205521978 0.235729283436186 no 836 0.290852757163207 1387 5281571 An antioxidant.
SGTC_1151 3909-8316 15.3 µM 0.549793046669786 0.236092193357366 no 837 0.291230664200114 1412 800431
SGTC_290 2043-6722 48.1 µM 0.549293624440744 0.236256740338642 no 838 0.291401980988977 1430 773758 YLR208W SEC13
SGTC_1609 st001574 46.4 µM 0.548529837380641 0.23650851094103 no 839 0.291664073736375 1379 3960012
SGTC_389 tpck 16.7 µM 0.545996752116631 0.237344559272742 no 840 0.292534084891312 1403 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2403 6032726 181.2 µM 0.545618305964474 0.237469605146781 no 841 0.292664169142885 1428 2881040
SGTC_2876 9059903 25.97 µM 0.544910741843536 0.237703494901741 no 842 0.292907453999766 1396 6916095
SGTC_1058 3448-5425 97.3 µM 0.544892753980691 0.237709442549339 no 843 0.292913640068303 1341 7279705
SGTC_1039 k821-0043 94 µM 0.544657905069115 0.237787102320085 no 844 0.292994410726888 1470 15992768
SGTC_490 phenamil 164 µM 0.544589684596878 0.237809664054305 no 845 0.293017875461212 1463 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2110 5483698 200 µM 0.544410709072307 0.237868860051614 no 846 0.293079439030993 1426 2848765 YHR062C RPP1
SGTC_295 k015-0027 31 µM 0.543838513683544 0.238058167373008 no 847 0.293276301662327 1394 3887424
SGTC_1603 st002045 67.8 µM 0.543607696281213 0.238134555256368 no 848 0.293355731253977 1407 5887985
SGTC_2913 7966556 36.57 µM 0.541122340313863 0.238957921945043 no 849 0.294211630403552 1463 2976516
SGTC_524 r073-0010 27.8 µM 0.540978753561366 0.23900553791888 no 850 0.294261113593682 1375 2772106
SGTC_905 2-aminofluorene 215 µM 0.540063832037057 0.239309064305469 no 851 0.294576506159605 1433 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.537505721796939 0.24015883700425 no 852 0.295459166828043 1450 4213774
SGTC_1925 st057770 10.1 µM 0.535119867606984 0.240952868327864 no 853 0.296283486232098 1340 5989122
SGTC_667 1498-1044 59 µM 0.534810629614651 0.241055889628965 no 854 0.296390406001818 1475 6739982
SGTC_2515 chrysin 20.77 µM 0.534519065976622 0.241153044727589 no 855 0.296491231018758 1487 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_796 1234-0020 70.7 µM 0.534081677360674 0.241298831665939 no 856 0.296642512936158 1393 46495034
SGTC_1025 k007-0731 70 µM 0.530214339481391 0.242589943711271 no 857 0.297981665036177 1418 6256118
SGTC_1524 corynanthine 62.1 µM 0.527160443867463 0.243612125296616 no 858 0.299041087626775 1503 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2442 5158906 48.48 µM 0.526307184019383 0.243898138460907 no 859 0.299337396179446 1552 1893835
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.525862899563476 0.244047134557091 no 860 0.299491733985977 1443 5106787 A p450 inhibitor.
SGTC_2462 5162487 171.77 µM 0.525764187609206 0.244080245453976 no 861 0.299526029946613 1421 2259986
SGTC_2183 6420625 130.508 µM 0.525455712961968 0.244183732550598 no 862 0.299633216222095 1428 2897619
SGTC_487 nimodipine 119 µM 0.522454806878601 0.24519171015583 no 863 0.300676852366717 1429 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3090 9117696 49.47 µM 0.521777520457563 0.2454195136943 no 864 0.300912621497321 1526 7923821
SGTC_1188 1403-0014 4.57 µM 0.521155102119984 0.245628962740526 no 865 0.301129364066738 1455 9614867
SGTC_407 eburnamonine 100 µM 0.521116046513344 0.2456421084834 no 866 0.301142966609802 1414 3195
SGTC_2413 inermin 26.06 µM 0.521106405901246 0.245645353479178 no 867 0.301146324348074 1595 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_269 exalamide 29 µM 0.520852263876433 0.245730905083834 no 868 0.301234845806853 1482 3316 A derivative of salicylamide.
SGTC_2623 humulene 100 µM 0.520345372419272 0.24590158726921 no 869 0.301411438654402 1382 6187145 An anti-inflammatory.
SGTC_1505 k297-0037 20.6 µM 0.519792098631894 0.246087960067156 no 870 0.301604243533112 1427 4089396
SGTC_536 3852-0578 10.6 µM 0.519389864344099 0.246223502071883 no 871 0.301744448975441 1548 2869208
SGTC_857 0438-0306 1.35 µM 0.518447009382167 0.246541375351011 no 872 0.302073211517503 1467 4686136
SGTC_419 nsc-638432 893 µM 0.518311058477599 0.246587227846191 no 873 0.302120629279281 1462 368090
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.51732268598003 0.246920715943402 no 874 0.302465460102385 1483 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_720 r052-1644 49.9 µM 0.517074041438476 0.247004649416012 no 875 0.302552236851964 1447 1422863 YOR257W CDC31
SGTC_1033 k072-0102 21.3 µM 0.516111991703202 0.247329546622053 no 876 0.302888096519083 1550 5965931
SGTC_984 1492-0255 2.91 µM 0.513999576979287 0.248043738418945 no 877 0.303626143210969 1495 1585198
SGTC_2757 clomiphene 4.22 µM 0.513053135323327 0.24836407989959 no 878 0.303957076266891 1587 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3142 9086498 49.47 µM 0.512443644489196 0.248570490535441 no 879 0.304170276100145 1413 25236367
SGTC_3187 9109394 49.47 µM 0.511397611301208 0.248924953847568 no 880 0.304536333606087 1375 17098090
SGTC_2112 5488546 200 µM 0.511221151665466 0.248984776227661 no 881 0.304598104666802 1421 600757
SGTC_3081 9117243 49.47 µM 0.510100621568337 0.249364830674218 no 882 0.304990484883747 1558 45595589
SGTC_1289 0976-0073 69.1 µM 0.509487615451228 0.249572876708733 no 883 0.305205238488907 1502 3391136
SGTC_2447 5741742 33.78 µM 0.509082734865224 0.249710338285642 no 884 0.305347116546763 1547 1776504
SGTC_950 1165-0508 94.1 µM 0.507331385090273 0.250305404330752 no 885 0.305961160329926 1445 6148369
SGTC_740 k014-0057 261 µM 0.50589994983198 0.250792329001574 no 886 0.30646344377055 1565 4012779
SGTC_292 k038-0015 474 µM 0.500786613895122 0.25253579608575 no 887 0.308260653730486 1494 46368540
SGTC_1948 st076329 66.6 µM 0.50017719689477 0.252744010838151 no 888 0.308475156607175 1406 24208413
SGTC_1654 st012436 41.8 µM 0.499084887913165 0.253117437622644 no 889 0.308859791635653 1489 4323132
SGTC_1965 Pectolinarigenin 58.4 µM 0.499058208776742 0.253126562026714 no 890 0.308869188791877 1456 5320438 An anti-inflammatory.
SGTC_2424 5537928 59.2 µM 0.498915262966885 0.253175453187322 no 891 0.308919540532612 1464 5382802
SGTC_2482 5981709 142.65 µM 0.49846510872813 0.253329450008519 no 892 0.309078127920821 1517 877755
SGTC_2127 5253358 187.912 µM 0.495840593131301 0.254228270819166 no 893 0.310003441232593 1430 20612
SGTC_2741 miltefosine 3.04 µM 0.495207445908143 0.254445355550132 no 894 0.310226847603097 1470 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_690 glyoxal 20.3 µM 0.4941874872547 0.254795268990175 no 895 0.310586887918335 1395 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3316 9136639 10.545 µM 0.49348994103009 0.255034718562171 no 896 0.310833222794886 1553 4903665
SGTC_646 4092-0839 27.3 µM 0.492248025995045 0.255461327061082 no 897 0.311272008587936 1573 877796
SGTC_1353 1498-1206 8.11 µM 0.489323830741053 0.256467283916218 no 898 0.31230622608426 1492 6756808
SGTC_1836 st055642 81 µM 0.488872764883523 0.256622639291508 no 899 0.312465889227689 1406 8571
SGTC_2950 9072895 21.46 µM 0.488228451399823 0.256844637672224 no 900 0.312694017025552 1437 17332245
SGTC_2505 galangin 7.89 µM 0.487374741039313 0.257138937676561 no 901 0.312996395126737 1436 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2644 guaiazulene 100 µM 0.486512094975193 0.257436496105292 no 902 0.313302066010916 1528 3515 A coloring agent.
SGTC_1772 st048439 82.2 µM 0.483267788198621 0.258557176591123 no 903 0.314452804272248 1481 2927068 YDL195W SEC31
SGTC_956 1185-0240 191 µM 0.483134846485091 0.258603152454832 no 904 0.314499996560641 1508 1416193
SGTC_3304 9125678 46.087 µM 0.48295180589339 0.258666461177152 no 905 0.314564978149344 1500 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_971 1315-0384 26.7 µM 0.481065723265314 0.259319272431671 no 906 0.315234894196619 1480 6769120
SGTC_1214 0358-0031 63.7 µM 0.479840494183084 0.259743804614869 no 907 0.315670408193356 1695 4301366
SGTC_3195 9113082 49.47 µM 0.479007779875794 0.260032538118048 no 908 0.315966547006542 1560 17018038
SGTC_2254 7938975 95.19 µM 0.478786257478532 0.260109376160157 no 909 0.316045347084695 1608 2969277
SGTC_788 1182-0090 188 µM 0.478774596080342 0.260113421398252 no 910 0.316049495515757 1670 5715185
SGTC_2874 9043904 71.43 µM 0.478156564995157 0.260327857429256 no 911 0.316269387304169 1495 4463428
SGTC_1579 chlormadinone acetate 49.4 µM 0.477541770027653 0.260541260960903 no 912 0.31648819218274 1612 45114258 A steroidal progestin.
SGTC_3348 9149464 3.537 µM 0.476675716994853 0.260842032250405 no 913 0.316796528526264 1495 1951442
SGTC_2031 5180455 200 µM 0.476659528531642 0.260847656036814 no 914 0.31680229323308 1481 29949
SGTC_835 0312-0010 67.2 µM 0.476245455276662 0.260991524091028 no 915 0.316949759710072 1495 1626196
SGTC_178 4092-0806 87.505 µM 0.475867504566033 0.261122877122608 no 916 0.317084387030036 1490 2169044
SGTC_2969 9091408 28.7 µM 0.472045569382036 0.26245305934587 no 917 0.318447131259433 1446 4286311
SGTC_559 1550-0661 158 µM 0.471618136877227 0.262602037888771 no 918 0.318599689313267 1582 5830875
SGTC_513 4245-1575 41.7 µM 0.471279635398277 0.262720050857715 no 919 0.318720528170358 1598 719745
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.470118819022123 0.263124956325393 no 920 0.319135064803987 1536 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_914 3820-6779 408 µM 0.468430460840899 0.263714442760597 no 921 0.3197383945415 1469 2893481
SGTC_1929 genistein trimethyl ether 50.5 µM 0.468205775984011 0.263792941724288 no 922 0.319818721020657 1681 136420
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.466407608717605 0.264421602915935 no 923 0.320461883144444 1528 442882
SGTC_2102 5377816 72.7585 µM 0.464321449628148 0.265151903863305 no 924 0.321208729252201 1635 1379702
SGTC_1105 epirubicin 18.1 µM 0.464059381079869 0.265243718474517 no 925 0.321302601162619 1478 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_148 3253-0744 288.01 µM 0.46345663774858 0.265454948297857 no 926 0.32151854474102 1490 6893655
SGTC_209 4077-0173 175.592 µM 0.462463298694721 0.265803247510523 no 927 0.321874557837535 1528 15993494
SGTC_1375 2910-0797 186 µM 0.461710551679303 0.266067340976202 no 928 0.322144451621118 1572 742508
SGTC_1960 st011366 51.8 µM 0.458697162970991 0.26712588620819 no 929 0.32322582581671 1531 3972846
SGTC_2336 9001819 198.65 µM 0.458556820144717 0.267175237696631 no 930 0.323276225268399 1640 2989602
SGTC_438 sphingosine 6.67 µM 0.457706007268997 0.26747452413059 no 931 0.323581835783186 1384 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1342 1486-1464 234 µM 0.457666980027424 0.267488256613819 no 932 0.323595857157579 1529 3253938
SGTC_2280 7785178 200 µM 0.456921020837025 0.267750804982465 no 933 0.3238639071337 1566 2954328
SGTC_2647 atorvastatin 60.16 µM 0.456777166065157 0.267801451149082 no 934 0.323915609842825 1600 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2511 berberine 10.47 µM 0.455532749692177 0.26823976740791 no 935 0.324363006091887 1540 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_323 4013-0906 34.3 µM 0.453289934843744 0.269030656359175 no 936 0.325169989776883 1625 2910086
SGTC_3129 9127257 49.47 µM 0.452915574274967 0.269162781878274 no 937 0.325304767891345 1428 837894
SGTC_2420 aureobasidin a 50 nM 0.452514036334582 0.269304535461377 no 938 0.325449355865432 1680 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1696 st025591 34.7925 µM 0.452121305761127 0.269443216015304 no 939 0.325590797850989 1561 2787147
SGTC_3314 9135860 59.4275 µM 0.45068869713319 0.269949400349745 no 940 0.326106964892924 1581 25252478
SGTC_3351 9150312 21.596 µM 0.450274395752505 0.270095874337215 no 941 0.326256299329409 1538 4904905
SGTC_2274 7947094 46.08 µM 0.450183346179744 0.270128069743949 no 942 0.326289121773821 1503 2971028
SGTC_1295 1013-0063 9.78 µM 0.449712758452771 0.270294501595163 no 943 0.326458785302206 1656 6826038
SGTC_1028 k015-0029 4.8 µM 0.449115305898965 0.270505875319499 no 944 0.326674239821857 1527 4588309
SGTC_1074 carmofur 3.8 µM 0.447076991060954 0.271227635039509 no 945 0.327409735699334 1563 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_138 0850-0259 40.9225 µM 0.446888158201185 0.271294548611933 no 946 0.327477907229984 1540 6813004
SGTC_1366 1683-0113 21.9 µM 0.445715625100942 0.271710223814802 no 947 0.327901338183087 1541 708623
SGTC_3084 9116877 49.47 µM 0.442536734819263 0.272838765989809 no 948 0.329050426965065 1612 27241325
SGTC_2004 4023728 41.89 µM 0.440889434869214 0.273424489388321 no 949 0.329646521329283 1659 360084 YDR527W RBA50
SGTC_2423 st077119 87.2 µM 0.440101010536192 0.273705046177479 no 950 0.329931975034877 1520 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2227 7312221 64.1025 µM 0.43927091336088 0.274000585845932 no 951 0.330232623695848 1591 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_952 1185-0122 232 µM 0.436329288898495 0.27504916099381 no 952 0.331298917261835 1520 678600
SGTC_3088 9117578 49.47 µM 0.436287542759724 0.275064056087626 no 953 0.331314059467354 1591 678341
SGTC_750 4073-0104 132 µM 0.435106042148665 0.275485782198163 no 954 0.331742728950319 1486 22330957
SGTC_942 3253-1115 227 µM 0.433834566448521 0.275939979130774 no 955 0.332204289230334 1665 46497897
SGTC_3050 9093513 49.47 µM 0.431468461380231 0.276786177773545 no 956 0.333063890001646 1561 25236664
SGTC_1347 1493-0251 600 nM 0.430449283235874 0.277151061397416 no 957 0.333434425961407 1691 3986378
SGTC_3327 9140648 26.9345 µM 0.429087408964448 0.277639003308701 no 958 0.3339298074545 1675 8029710
SGTC_3228 9131799 49.47 µM 0.428084745597147 0.277998512627448 no 959 0.334294711169983 1623 17015818
SGTC_2737 bleomycin 30.5 nM 0.428077686501957 0.278001044501816 no 960 0.334297280773431 1592 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2720 fluspirilene 36.88 µM 0.427677013662047 0.278144771628714 no 961 0.334443143679597 1633 3396 An atypical antipsychotic.
SGTC_2933 9026794 32.47 µM 0.427379348292056 0.278251571948507 no 962 0.334551523425656 1637 17586027
SGTC_2961 9083290 32.55 µM 0.427378777421199 0.278251776792314 no 963 0.334551731292573 1601 17741490
SGTC_2253 7938677 135.83 µM 0.425009655347871 0.279102514168058 no 964 0.335414818081593 1694 2301972
SGTC_1597 7-benzyloxygramine 47.5 µM 0.424332670174029 0.279345847562003 no 965 0.335661608144083 1555 260807
SGTC_1758 st042942 75.2445 µM 0.423569791368882 0.279620177743545 no 966 0.335939795075426 1584 669317
SGTC_1026 k007-1105 30.6 µM 0.422885078236238 0.279866510960285 no 967 0.336189555132695 1582 7066794
SGTC_1042 0350-0096 82 µM 0.421367744218205 0.280412763619567 no 968 0.336743284562074 1551 3122515
SGTC_1822 st052468 42 µM 0.419586290679317 0.281054759532198 no 969 0.337393852545363 1562 2873678
SGTC_2667 digitoxin 100 µM 0.418520731754755 0.281439102183684 no 970 0.337783216007533 1644 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_904 1141-0088 396 µM 0.418027804221381 0.281616984840841 no 971 0.337963394313434 1512 1378119
SGTC_605 1315-0399 119 µM 0.41772631884174 0.281725808522697 no 972 0.33807361365199 1648 24020461
SGTC_1937 st074714 47.2 µM 0.417474044431537 0.281816884667411 no 973 0.338165852734873 1518 17250970
SGTC_2869 9037858 32.47 µM 0.41719797941603 0.281916565956752 no 974 0.338266801508076 1538 27187042
SGTC_2162 5663267 200 µM 0.416517436023358 0.282162368432567 no 975 0.338515705653082 1697 6456493
SGTC_2178 5812956 200 µM 0.416394016630785 0.282206956789259 no 976 0.338560853023246 1612 5403383
SGTC_1793 st048256 72.231 µM 0.416277567280079 0.28224903015238 no 977 0.338603452848067 1572 672022
SGTC_1812 st052057 4.327 µM 0.412570388514269 0.283590015845708 no 978 0.339960700036981 1569 3645418
SGTC_727 3032-0951 202 µM 0.411604780571147 0.283939802482298 no 979 0.340314563535626 1643 3652836
SGTC_1287 0971-0001 34.6 µM 0.411488514590705 0.283981933173398 no 980 0.340357180681004 1636 4665869
SGTC_2358 9037157 4 µM 0.410477214192901 0.284348518877441 no 981 0.340727957486166 1648 2388925
SGTC_411 enrofloxacin 100 µM 0.409131476216413 0.284836685082421 no 982 0.341221589054727 1770 71188 A bacterial gyrase inhibitor.
SGTC_1047 2043-3044 82 µM 0.407889203611073 0.285287673872922 no 983 0.341677509709521 1557 669592
SGTC_1996 st072960 66.8 µM 0.40631510564604 0.285859615118762 no 984 0.34225554386826 1713 1719405
SGTC_2317 5986382 200 µM 0.406183322816152 0.285907522525105 no 985 0.34230395344176 1745 877883
SGTC_313 3474-0040 5.03 µM 0.405452704847948 0.286173195479174 no 986 0.342572388234229 1586 1043375 YIL048W NEO1
SGTC_2222 6885208 172.143 µM 0.404192296582841 0.286631790309558 no 987 0.343035659027732 1636 609514
SGTC_614 0462-0418 107 µM 0.403290487391865 0.286960123955667 no 988 0.343367269445812 1548 5188303
SGTC_2364 9055074 200 µM 0.402210170177046 0.287353683788969 no 989 0.343764679053743 1564 6470630
SGTC_2077 5212015 200 µM 0.400692692938783 0.287906931995593 no 990 0.344323195621989 1547 780900
SGTC_2996 9066192 71.4286 µM 0.399198667611087 0.288452120893394 no 991 0.34487341245016 1536 6472854
SGTC_697 0508-1955 564 µM 0.399185160606298 0.288457051990375 no 992 0.344878388283184 1733 6243113
SGTC_1834 st055981 52.8 µM 0.396852848011794 0.289309120838751 no 993 0.345737988396258 1734 471719 YDL150W RPC53
SGTC_3022 9087993 49.47 µM 0.396461683679851 0.289452141498683 no 994 0.345882234475704 1677 17173644
SGTC_2068 5226020 147 µM 0.396442833325038 0.289459034556221 no 995 0.34588918631316 1596 1810509
SGTC_2197 6588183 93.1375 µM 0.39549161931994 0.289806967485888 no 996 0.346240052698247 1635 884136
SGTC_563 tetrahydrosecaminediol 614 µM 0.394954304386138 0.290003592017681 no 997 0.346438305948156 1736 334274 A psychoactive constituent of the cannabis plant.
SGTC_3236 9132701 49.47 µM 0.39436349647361 0.290219863885108 no 998 0.346656345085145 1589 24282524
SGTC_1280 0880-0253 10.1 µM 0.393008915841362 0.290716008331149 no 999 0.347156448134874 1616 6836607
SGTC_2740 felodipine 17.08 µM 0.392403524461797 0.290937874195659 no 1000 0.347380041154677 1745 3333 L-type calcium channel blocker
SGTC_593 1203-0218 61.7 µM 0.39192966001012 0.291111592817939 no 1001 0.347555093571664 1739 3666956
SGTC_606 k015-0008 38.6 µM 0.390758365153672 0.291541197029264 no 1002 0.347987926359025 1759 1970475
SGTC_1600 coumarin 106 71.1 µM 0.389978302373796 0.291827470159646 no 1003 0.348276295711046 1674 100336 A hepatotoxic, DNA x-linker.
SGTC_696 1560-0013 611 µM 0.386248763374476 0.293197970000052 no 1004 0.349656221264136 1706 1650269
SGTC_393 acivicin 6.25 µM 0.38535730450132 0.293525997212586 no 1005 0.349986355303593 1646 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_926 2268-1401 59.4 µM 0.385316192834971 0.293541129037146 no 1006 0.350001582928338 1619 2931578
SGTC_1239 0337-0584 35.4 µM 0.384524557005482 0.293832574038339 no 1007 0.350294849228894 1785 914301 YML130C ERO1
SGTC_3147 9097027 49.47 µM 0.384000468700803 0.294025593589728 no 1008 0.350489050054691 1741 25236841
SGTC_901 1112-0062 60.1 µM 0.383225151932824 0.294311246991158 no 1009 0.35077641521139 1657 1908457
SGTC_749 1000-0129 128 µM 0.380687222501992 0.295247202827314 no 1010 0.35171767559987 1793 708470
SGTC_2936 9038235 15.59 µM 0.379968834390941 0.295512383730369 no 1011 0.351984274881035 1627 4749415
SGTC_1180 1193-0155 285 µM 0.378369146807682 0.296103274668117 no 1012 0.352578192393897 1625 2921347
SGTC_3158 9100007 49.47 µM 0.377785827937365 0.296318875204753 no 1013 0.352794851276172 1612 19297233
SGTC_318 1488-0629 67.2 µM 0.376458561684022 0.296809714229058 no 1014 0.35328800822904 1629 3662576
SGTC_412 gemfibrozil 100 µM 0.375823351011196 0.297044754376909 no 1015 0.353524113355027 1683 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2905 7799065 20.05 µM 0.375712589003815 0.297085747160824 no 1016 0.353565288899714 1759 1296806
SGTC_745 0469-0705 296 µM 0.373099004849664 0.298053778841718 no 1017 0.354537379654393 1784 3486736
SGTC_400 oxethazaine 37.5 µM 0.372249698802288 0.298368657984136 no 1018 0.354853473122767 1652 4621 A local anesthetic.
SGTC_3004 9076122 71.4286 µM 0.371892952186941 0.298500966482653 no 1019 0.354986276370883 1747 44782551
SGTC_802 4112-3352 742 µM 0.371355177532605 0.298700464233686 no 1020 0.355186502795231 1765 704594
SGTC_553 k007-0256 45.7 µM 0.370928556696932 0.2988587704616 no 1021 0.355345372430759 1698 6287000
SGTC_79 0052-0007 94.094 µM 0.370589853025646 0.298984480399672 no 1022 0.355471520436684 1761 2801472
SGTC_1207 2099-0101 141 µM 0.368236852009033 0.299858459316452 no 1023 0.3563483169818 1789 5837381
SGTC_2289 7946404 165.07 µM 0.367718820975056 0.300051027642031 no 1024 0.356541452626568 1633 1246120 YPR165W RHO1
SGTC_1700 st030840 7.9285 µM 0.367334519146409 0.300193920778053 no 1025 0.356684754268219 1795 5499307
SGTC_2131 toluylene red 5.2905 µM 0.367030392844806 0.300307024430759 no 1026 0.356798173737846 1605 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2400 5203494 178.7 µM 0.36640484716513 0.300539723505344 no 1027 0.357031501671021 1623 6777674
SGTC_2154 5570129 200 µM 0.365832490558296 0.300752707883081 no 1028 0.357245036990707 1676 673366
SGTC_955 1216-0110 33 µM 0.363604525665496 0.301582422185098 no 1029 0.35807667339901 1607 3619719
SGTC_2868 9035608 32.47 µM 0.362653651727571 0.301936849487587 no 1030 0.358431813216114 1636 6462614
SGTC_678 1218-2179 85.9 µM 0.362579761661985 0.301964398992049 no 1031 0.358459415386782 1723 6820081 YOR116C RPO31
SGTC_417 st075190 100 µM 0.362520265327859 0.301986582693537 no 1032 0.358481641211977 1799 222757
SGTC_135 0933-0004 26.348 µM 0.360277387899916 0.302823391475252 no 1033 0.359319853684221 1634 21230617 YGL099W LSG1
SGTC_601 0986-0029 62.9 µM 0.359868168468253 0.302976181578423 no 1034 0.359472861159439 1689 24747981
SGTC_2704 st078022 71.1 µM 0.358768417198168 0.303386966125485 no 1035 0.359884170637958 1822 54697681
SGTC_520 3584-0023 682 µM 0.358713863427008 0.303407349797978 no 1036 0.359904578101745 1655 1340790
SGTC_1179 1021-1431 9.29 µM 0.357438497859362 0.303884056350229 no 1037 0.360381780286436 1713 2840958
SGTC_1765 st044815 90.4 µM 0.35501311237424 0.304791538072511 no 1038 0.361289884000263 1618 645695
SGTC_1183 1254-0324 198 µM 0.353860204790806 0.30522333169233 no 1039 0.361721825909488 1775 5799357
SGTC_1161 k007-0610 110 µM 0.353316664887218 0.305426995515449 no 1040 0.361925526696932 1743 5843850
SGTC_2362 9071156 126 µM 0.353175155492499 0.305480028819857 no 1041 0.361978566160823 1754 653133
SGTC_2847 9005661 71.43 µM 0.351968157520294 0.30593253979246 no 1042 0.362431071502653 1714 2991449
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.349563156532818 0.306835072655858 no 1043 0.36333328264537 1806 16725076
SGTC_2290 7904846 200 µM 0.349131219061438 0.306997291612682 no 1044 0.363495400013372 1664 2962154
SGTC_1490 4089-0339 670 nM 0.348663976704738 0.307172812265067 no 1045 0.363670795751223 1806 742542
SGTC_1657 st012939 43.4 µM 0.348547193318129 0.307216689113359 no 1046 0.363714638939342 1793 24207257
SGTC_1392 3455-1037 33.9 µM 0.348194086315263 0.307349372222422 no 1047 0.363847214340134 1782 981132
SGTC_2419 paclitaxel 166.5 µM 0.347704042872008 0.307533552203298 no 1048 0.364031230067561 1740 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_386 1509-0011 3.07 µM 0.346037183188139 0.308160394807623 no 1049 0.364657385390622 1694 3107280
SGTC_2341 7987486 176.74 µM 0.345574263190603 0.308334580859948 no 1050 0.364831345307081 1857 1258686
SGTC_2788 5282734 71.43 µM 0.344501770104434 0.308738300903772 no 1051 0.365234482531982 1832 743706
SGTC_2588 indole-3-carbinol 100 µM 0.344055559992913 0.308906336539801 no 1052 0.365402251443032 1854 3712 Induces cell cycle arrest.
SGTC_2602 kawain 100 µM 0.343538669787645 0.30910103918609 no 1053 0.365596627303917 1724 5369129
SGTC_1378 2093-0007 380 nM 0.343421213033507 0.30914529037779 no 1054 0.365640801571897 1705 3618014
SGTC_825 1988-2224 89.6 µM 0.342745720169335 0.309399832371406 no 1055 0.36589488201222 1710 1180859
SGTC_1098 clofazimine 15.1 µM 0.340898103493439 0.310096525919155 no 1056 0.366590146294596 1786 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1164 k060-0068 93.7 µM 0.335356715248143 0.312190139657459 no 1057 0.368678007752617 1728 5963676
SGTC_2263 7948595 193.29 µM 0.335059335916272 0.312302666186959 no 1058 0.368790163419464 1700 2971371
SGTC_968 1309-0633 340 µM 0.333281300586983 0.312975828945744 no 1059 0.369460976637808 1841 3761976
SGTC_2891 9063876 19.48 µM 0.332938164959817 0.313105811718883 no 1060 0.369590479916497 1881 6472478
SGTC_2221 6807166 181.081 µM 0.331439491227694 0.313673794534926 no 1061 0.370156269637874 1785 674925
SGTC_2204 7233102 200 µM 0.329484686408649 0.314415310714478 no 1062 0.370894683428607 1785 2172480
SGTC_335 4077-0256 27.6 µM 0.328942208070344 0.314621222009932 no 1063 0.371099685250046 1820 3121989
SGTC_2093 5331342 194.4 µM 0.328613222592696 0.314746124816417 no 1064 0.371224026236039 1835 33839
SGTC_813 k007-0158 173 µM 0.328076281091341 0.314950025847498 no 1065 0.371426993655439 1819 6523916
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.328067350113034 0.314953417821988 no 1066 0.371430369926455 1761 97141
SGTC_322 k048-0136 19.3 µM 0.327846955147676 0.31503712850095 no 1067 0.371513691270869 1763 6823282
SGTC_891 0929-0073 133 µM 0.327636853193587 0.315116938522069 no 1068 0.371593126899891 1811 5603632
SGTC_3126 9127922 49.47 µM 0.32756420696661 0.315144536165738 no 1069 0.371620594355388 1765 45595682
SGTC_2282 7944268 200 µM 0.327551778064425 0.315149257896477 no 1070 0.371625293774601 1801 2970414
SGTC_188 3229-0966 278.469 µM 0.327282615392328 0.315251520004256 no 1071 0.371727069984221 1864 5722370
SGTC_3300 9124615 50.48 µM 0.327119906979234 0.315313344154199 no 1072 0.3717885978919 1806 24824903
SGTC_232 clozapine 119 µM 0.326073530010606 0.315711058463035 no 1073 0.372184361739186 1781 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_265 mycophenolic acid 32.932 µM 0.325834695987321 0.315801866119515 no 1074 0.372274713207673 1847 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2293 7624732 200 µM 0.324785308933402 0.316200987782722 no 1075 0.372671782037859 1667 894453
SGTC_1573 oleylamine 1.06 µM 0.324232039076149 0.316411503566626 no 1076 0.372881183731386 1684 5356789 An amine of the fatty acid oleic acid.
SGTC_2791 5663188 71.43 µM 0.323818573520505 0.31656886352571 no 1077 0.373037696793787 1834 54690634
SGTC_2207 7258803 200 µM 0.323422734010823 0.316719546341564 no 1078 0.373187557336697 1811 3666799
SGTC_1966 st070145 16.1 µM 0.322691634737828 0.316997931249951 no 1079 0.373464394016737 1694 3748532
SGTC_23 0213-0011 39.996 µM 0.322376140404552 0.317118095872014 no 1080 0.373583878692815 1858 627608
SGTC_2027 5150920 200 µM 0.321513367504773 0.317446804922355 no 1081 0.37391069188538 1807 786715
SGTC_590 k048-0076 22.4 µM 0.321512812005406 0.31744701660925 no 1082 0.373910902334434 1846 6832814
SGTC_1990 st072050 59.8 µM 0.321139932776854 0.317589125011595 no 1083 0.374052174845255 1699 17233948
SGTC_1187 1391-0724 117 µM 0.320007681142694 0.318020803325749 no 1084 0.374481253892701 1769 6997986
SGTC_2540 epiandrosterone 100 µM 0.319233983779698 0.318315922795704 no 1085 0.374774544367467 1747 441302 A steroid.
SGTC_1780 st038448 24.544 µM 0.319024735049944 0.318395758549789 no 1086 0.374853878093106 1833 728868 YDL195W SEC31
SGTC_2296 7971656 126.45 µM 0.31629197856715 0.319439174544412 no 1087 0.375890449529862 1718 666570
SGTC_859 0439-0102 54.6 µM 0.314974259341813 0.319942815683156 no 1088 0.376390598968118 1882 610143
SGTC_2513 baicalein 25.65 µM 0.314167360257503 0.320251381924519 no 1089 0.376696965638919 1667 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1467 k284-1082 293 µM 0.313113989156273 0.320654388611009 no 1090 0.377097030649983 1875 3334705
SGTC_1959 st077091 55.8 µM 0.311218941761848 0.321379942453104 no 1091 0.377817092065801 1744 821356 YKL052C ASK1
SGTC_2838 9002687 71.43 µM 0.310289409661774 0.321736080493183 no 1092 0.378170441934925 1692 6457060
SGTC_1820 st053765 18.6 µM 0.308940118953926 0.322253335037824 no 1093 0.378683539020982 1715 3690829
SGTC_2811 7967822 32.47 µM 0.308524102610138 0.322412885630106 no 1094 0.378841781455004 1836 2232244
SGTC_2237 6667747 47.222 µM 0.308033996541435 0.322600893089201 no 1095 0.37902823186507 1722 729940 YDL015C TSC13
SGTC_1875 nocodazole 6 µM 0.307075910915244 0.322968551145631 no 1096 0.379392796390951 1903 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_807 1315-0151 48 µM 0.306777337712751 0.323083161721616 no 1097 0.379506429466774 1915 4011080
SGTC_1756 st041558 35.5 µM 0.306367295676277 0.323240588198452 no 1098 0.379662503091642 1926 3955792
SGTC_2070 5230947 200 µM 0.306180964168543 0.323312136480479 no 1099 0.37973343262747 1872 2835538
SGTC_1298 1079-1278 263 µM 0.306035240895515 0.323368096412097 no 1100 0.379788906925434 1785 2840950
SGTC_2246 7293507 91.5585 µM 0.305983642178295 0.323387912054699 no 1101 0.379808550246578 1919 887656
SGTC_1583 clindamycin 39.6 µM 0.305831857815263 0.323446205258558 no 1102 0.379866335438024 1693 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2553 4-methylesculetin 85.09 µM 0.305054245757284 0.323744917266032 no 1103 0.380162418927826 1727 5319502
SGTC_1080 nisoldipine 24.4 µM 0.304151317670025 0.324091910695841 no 1104 0.38050630586121 1758 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_465 cgp-37157 41 µM 0.30382373350276 0.324217838435157 no 1105 0.380631092111539 1859 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1938 st074717 56.4 µM 0.302708058746499 0.324646869560784 no 1106 0.381056177890432 1741 17250979
SGTC_738 1315-0003 72.4 µM 0.301281390482165 0.325195831904426 no 1107 0.381599965149589 1874 6251474
SGTC_564 3555-0129 330 µM 0.300526523843389 0.32548644786136 no 1108 0.381887783900742 1883 563260
SGTC_296 1222-0039 74.9 µM 0.300466201181571 0.325509676052581 no 1109 0.38191078680053 1737 5984176
SGTC_1648 st011736 69.8 µM 0.300345927485947 0.325555991356397 no 1110 0.381956652131132 1864 2855514
SGTC_2201 6605497 169.863 µM 0.300209630587227 0.325608480172079 no 1111 0.382008629773876 1874 670741
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.299319695421885 0.325951284913969 no 1112 0.382348064146488 1913 1273210
SGTC_2764 methyldopa 94.69 µM 0.299053086210992 0.326054011958739 no 1113 0.382449770438806 1895 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_568 1193-0097 7.48 µM 0.297753416497782 0.326554975896566 no 1114 0.382945685466483 1837 3646150
SGTC_1336 1486-0901 104 µM 0.297431184197613 0.326679230334172 no 1115 0.383068669383243 1824 5006114
SGTC_3185 9108267 49.47 µM 0.296777370150377 0.326931403477155 no 1116 0.383318241758516 1719 4910486
SGTC_141 0443-0274 32.331 µM 0.295833798462558 0.327295474195089 no 1117 0.383678505102813 1935 1627241
SGTC_877 0771-0151 33.1 µM 0.295512530750018 0.327419470680603 no 1118 0.383801190695246 1804 6166523
SGTC_686 1319-0111 510 µM 0.294884347292694 0.32766197937587 no 1119 0.38404111480066 1886 4562600
SGTC_1480 1070-0044 41.2 µM 0.293846589038443 0.32806276267682 no 1120 0.384437566435051 1874 3124987
SGTC_1246 0422-0085 105 µM 0.292955861372275 0.328406920585468 no 1121 0.384777944865103 1922 264295
SGTC_1950 st077106 7.18 µM 0.29269074078108 0.328509385590444 no 1122 0.384879273951862 1749 13831864
SGTC_2722 naftopidil 47.16 µM 0.292330075256348 0.328648797940132 no 1123 0.385017132934395 1870 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2022 5136654 200 µM 0.29044388418134 0.329378278071609 no 1124 0.385738337567548 1805 1713771
SGTC_2124 5246320 200 µM 0.289652330184929 0.329684603552667 no 1125 0.386041114272959 1838 579342
SGTC_1000 4048-0884 8.67 µM 0.289305234711502 0.329818962965419 no 1126 0.386173903400281 1817 13040088
SGTC_819 1013-0258 27.7 µM 0.289043349180097 0.329920352452685 no 1127 0.386274102387787 1796 5753198
SGTC_3284 9108171 64.8615 µM 0.288620952933636 0.330083910301092 no 1128 0.386435729725432 1810 8687505
SGTC_668 1682-0499 62.6 µM 0.287495271836739 0.330519948622632 no 1129 0.386866560867345 1798 682214
SGTC_1984 st072354 53.1 µM 0.286723678908991 0.330818962075148 no 1130 0.387161952674187 1822 5762938
SGTC_918 glabranin 770.725 nM 0.285883043367408 0.331144854338769 no 1131 0.387483850709651 1836 124049 Also referred to as licorice root.
SGTC_3323 9138564 53.9225 µM 0.284182287759232 0.331804583603691 no 1132 0.388135344231149 1933 43912313 YNL103W MET4
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.283577819100734 0.332039185009378 no 1133 0.388366968686264 1909 279621
SGTC_29 0299-0004 12.984 µM 0.283276270389299 0.332156244242888 no 1134 0.388482533044069 1871 16871 A napthoquinone isolated from Swertia calycina.
SGTC_102 gallobenzophenone 83.616 µM 0.279800829590264 0.333506567369347 no 1135 0.389815157596534 1900 70837
SGTC_2091 4-phenylthiadiazole 200 µM 0.278996660926727 0.333819321724056 no 1136 0.390123693630475 1805 270010
SGTC_2107 5363541 170.161 µM 0.278854021336284 0.333874808660072 no 1137 0.390178427510432 1855 244052
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.278653947359611 0.333952643747534 no 1138 0.390255203868483 1881 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1424 4048-1941 275 µM 0.277409424949851 0.334436962528865 no 1139 0.390732872726461 1943 X1424
SGTC_1798 st045719 60.953 µM 0.276857455168239 0.334651855585041 no 1140 0.390944780952435 1903 3980186
SGTC_1444 4112-3581 28 µM 0.276344222654088 0.334851716041156 no 1141 0.391141846505697 1832 2877249
SGTC_2944 9067346 25.62 µM 0.275330687337835 0.335246539312847 no 1142 0.39153109505647 1865 6473075
SGTC_1827 berberine 7.24 µM 0.275316594861432 0.335252030329587 no 1143 0.391536508043002 1683 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1162 k048-0130 20.1 µM 0.275298906891723 0.335258922350342 no 1144 0.391543302105162 1805 6797406
SGTC_2776 terbinafine 19.92 µM 0.273777834324945 0.335851807175717 no 1145 0.392127679337585 1860 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1787 fluconazole 80 µM 0.27288513899695 0.33619995308357 no 1146 0.392470755245953 1833 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1413 3910-0535 34.4 µM 0.271903463413552 0.336582963009779 no 1147 0.392848124058776 1914 2876951
SGTC_2153 5569715 200 µM 0.27114707685861 0.336878190018488 no 1148 0.39313895758252 1843 2054701
SGTC_2434 5670830 169.91 µM 0.270941058459981 0.336958618969721 no 1149 0.393218182788094 1817 1549830
SGTC_3265 9137266 49.47 µM 0.27061403554793 0.337086303019913 no 1150 0.393343949847186 2004 17224265
SGTC_3074 9116018 49.47 µM 0.26955100662372 0.337501485632117 no 1151 0.393752848252328 1837 17027303
SGTC_347 4534-1311 26.2 µM 0.26842892709236 0.337939946081587 no 1152 0.394184587833075 1802 2862016
SGTC_287 k060-0039 29.6 µM 0.267420783687798 0.338334072820406 no 1153 0.3945725994456 1941 5861974
SGTC_1982 st072467 71.9 µM 0.264764541441097 0.339373360015643 no 1154 0.395595427073288 1806 3163533
SGTC_1539 benzyladenosine 56 µM 0.263886409663748 0.339717209167778 no 1155 0.395933724046559 1837 92208 A nucleotide analog.
SGTC_2978 9011784 42.97 µM 0.263487799825414 0.339873336457705 no 1156 0.396087312877943 1999 2994934
SGTC_309 k408-0051 1.48 µM 0.261034924339868 0.340834681177073 no 1157 0.397032787460528 1856 3640463
SGTC_1272 0839-0021 27 µM 0.259238431098 0.34153942964674 no 1158 0.397725640311641 1875 5027250
SGTC_695 3505-6186 243 µM 0.25866360261772 0.341765046655556 no 1159 0.397947402445984 1882 1819379
SGTC_3297 9117502 71.43 µM 0.25827818445345 0.341916352825136 no 1160 0.398096110757353 1916 7453720
SGTC_3060 1327-0027 12.5 µM 0.257579075272384 0.3421908715546 no 1161 0.39836589021046 1971 16000455 YPR107C YTH1
SGTC_3098 9119039 49.47 µM 0.253745174529092 0.343697806577089 no 1162 0.399846215848179 1846 17161528
SGTC_1668 st014914 51.6 µM 0.251732324228107 0.344489965320986 no 1163 0.400623985130406 1903 2839556
SGTC_3281 9140613 49.47 µM 0.251482101341059 0.344588488493843 no 1164 0.400720699349832 1765 16013766
SGTC_3287 9117173 37.0625 µM 0.250620452603749 0.344927836118519 no 1165 0.401053783698187 1962 2789709
SGTC_1327 1436-0082 2.18 µM 0.249884933711627 0.345217608095436 no 1166 0.401338167421965 1868 15992205
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.249771754562134 0.345262205285547 no 1167 0.401381932067968 1889 165521
SGTC_2576 guaiol 23.12 µM 0.249242305057956 0.345470858461366 no 1168 0.401586678515492 2016 227829
SGTC_305 1682-2595 20.8 µM 0.249089042894046 0.345531267016264 no 1169 0.401645952449265 1895 226033
SGTC_836 0330-0104 1.35 µM 0.249073276067581 0.345537481762204 no 1170 0.401652050376383 1885 46494820
SGTC_1222 0366-0074 1.18 µM 0.248635958991968 0.345709873844713 no 1171 0.401821195261236 1976 286520
SGTC_936 3005-4620 401 µM 0.244248197765737 0.34744131213612 no 1172 0.403519300374433 1994 777207
SGTC_2569 tetrandrine 100 µM 0.242585278162733 0.348098345798249 no 1173 0.404163343466948 1795 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1173 0443-0020 122 µM 0.241977959105246 0.348338416563653 no 1174 0.404398620937657 1846 5331295
SGTC_453 enantio-paf c16 10 µM 0.241040303773575 0.348709187242325 no 1175 0.404761939682249 1929 13871343 A lipid and platelet activating factor
SGTC_2666 tannic acid 100 µM 0.240885546058436 0.348770395940938 no 1176 0.404821912454661 1909 16134267 A thiamine antagonist.
SGTC_378 3970-0959 8.33 µM 0.240609458781157 0.348879601841109 no 1177 0.404928909243333 1909 6615653
SGTC_93 0109-0045 59.227 µM 0.239854858699877 0.349178146598697 no 1178 0.40522138846135 1999 88733
SGTC_576 1073-0113 22.7 µM 0.239815692735132 0.349193644500215 no 1179 0.405236570440016 2008 5439563
SGTC_2155 5570423 76 µM 0.23951002482768 0.349314605377705 no 1180 0.40535506197971 1869 797402
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.239162246582357 0.349452249044677 no 1181 0.405489888055412 1903 91467 include heat shock
SGTC_66 0109-0187 42.4 µM 0.237468603740892 0.350122841658018 no 1182 0.406146636623803 1767 759417
SGTC_2954 9074818 52.69 µM 0.237106616856193 0.350266229963095 no 1183 0.406287039606788 1926 16648742
SGTC_1888 azatryptophan 97.5 µM 0.23708255436412 0.350275762225345 no 1184 0.406296373095118 1879 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_114 0364-0001 490.298 µM 0.236676783610561 0.350436520925614 no 1185 0.40645377364433 1836 4003655
SGTC_1486 3970-0793 4.53 µM 0.235824170746584 0.350774397291496 no 1186 0.406784555756215 1999 2844330
SGTC_3220 9131269 49.47 µM 0.234792318952183 0.351183460955771 no 1187 0.407184964852626 1924 17722206
SGTC_2600 tangeritin 87.95 µM 0.234666289863841 0.351233435309564 no 1188 0.407233876975787 1839 68077 A bioactive flavone.
SGTC_2803 7707263 71.43 µM 0.234348117469207 0.351359611751971 no 1189 0.407357366707168 1851 2199229
SGTC_2537 larixol 68.93 µM 0.234115482367529 0.351451877357765 no 1190 0.407447663354838 1907 6708759
SGTC_1809 st050081 57.6 µM 0.233753749630686 0.351595361872663 no 1191 0.407588078646762 1981 5036894
SGTC_374 0880-0231 82.3 µM 0.233484471644193 0.351702187117422 no 1192 0.407692613106212 1955 6833587
SGTC_2276 7947513 42.08 µM 0.232884035167591 0.351940428373205 no 1193 0.407925727864305 1725 2105100
SGTC_728 3030-5151 22.5 µM 0.232399782796922 0.352132612443883 no 1194 0.408113758804815 1901 3125388
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.230204615759917 0.35300427615983 no 1195 0.408966387657463 1881 688803
SGTC_2164 5685496 200 µM 0.229904533481236 0.353123493838374 no 1196 0.409082976736635 1986 759046
SGTC_2294 7971431 200 µM 0.22866343822172 0.3536167132689 no 1197 0.409565256986072 1967 5741572
SGTC_1118 chelidonine 707.474 nM 0.22721637360595 0.354192096692982 no 1198 0.410127748171918 2045 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2792 7535235 81.82 µM 0.226097676343876 0.354637142666165 no 1199 0.410562725905354 1835 1281891
SGTC_2563 tomatine 8.54 µM 0.224928918000358 0.355102316227862 no 1200 0.411017286173764 2125 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_103 0844-0104 51.839 µM 0.224314224592266 0.355347055011076 no 1201 0.41125640429161 1998 5375804
SGTC_1300 1094-0077 113 µM 0.22326345992482 0.355765552708037 no 1202 0.411665232129409 1876 5532636
SGTC_1897 st060201 15 µM 0.223159284465725 0.355807053108132 no 1203 0.411705769585655 1841 611878
SGTC_3162 9099653 49.47 µM 0.222354726986175 0.356127622376202 no 1204 0.41201887612402 2015 25237511
SGTC_284 0988-0104 32.6 µM 0.222031420867606 0.356256469687014 no 1205 0.412144711711237 1998 4666532
SGTC_3125 9127534 49.47 µM 0.221627599499111 0.356417427823217 no 1206 0.41230189772696 2056 1639235
SGTC_507 nimesulide 162 µM 0.221307827851797 0.356544902943499 no 1207 0.412426377673076 2021 4495 A COX2 inhibitor.
SGTC_1147 3809-1045 12.3 µM 0.217839904457506 0.357928397282105 no 1208 0.413776925918688 1892 325925
SGTC_2916 7875993 68.79 µM 0.216932946200286 0.358290528377379 no 1209 0.414130300782749 2081 1299250
SGTC_1671 st016596 74.5 µM 0.216885151729886 0.358309615335119 no 1210 0.414148924700398 1931 2829167
SGTC_2893 9048488 25.97 µM 0.216599893555716 0.358423541956541 no 1211 0.414260084349424 1847 6467338
SGTC_2765 myclobutanil 7.74 µM 0.216585171922993 0.358429421835217 no 1212 0.414265821274295 1923 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_669 0108-0021 26.2 µM 0.215968004769493 0.358675951034858 no 1213 0.414506343757597 2136 17201
SGTC_2351 9026858 72.31 µM 0.215717814355862 0.358775907100048 no 1214 0.414603857144093 1878 1409300
SGTC_3019 9081971 49.47 µM 0.21566307796201 0.358797776671988 no 1215 0.414625191721439 2020 16451803
SGTC_2763 lisinopril 49.32 µM 0.213820992588953 0.359534039481192 no 1216 0.415343326901818 2071 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_121 0557-0495 61.343 µM 0.213747331183073 0.359563492063432 no 1217 0.415372049627055 1886 3104427
SGTC_501 nsc-95397 161 µM 0.213729927731068 0.359570450735617 no 1218 0.415378835805375 2008 262093
SGTC_2248 tofa 1.1 µM 0.212883507652722 0.359908943196339 no 1219 0.415708913261771 1916 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.21266384737879 0.359996805665297 no 1220 0.415794583654433 1881 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_645 0845-0943 5.41 µM 0.212640805857918 0.360006022530309 no 1221 0.415803570382273 1939 1885106
SGTC_1301 naphtanilide LB 4.81 µM 0.212472741775713 0.360073252496898 no 1222 0.415869120605981 2026 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2213 7173844 200 µM 0.211854799756886 0.360320482438572 no 1223 0.416110157341443 1921 892728
SGTC_2991 9074669 71.4286 µM 0.210505724848114 0.360860431267705 no 1224 0.416636491991107 1999 17333109
SGTC_481 bay k-8644 50 µM 0.209658062695077 0.361199838484225 no 1225 0.416967279561846 1886 2303 A calcium channel antagonist.
SGTC_510 ag-490 170 µM 0.205200242205403 0.362986560230179 no 1226 0.418707840109057 2074 5328779
SGTC_2558 carylophyllene oxide 100 µM 0.205099082677877 0.363027140386687 no 1227 0.418747356558453 2078 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_176 1486-1328 72.834 µM 0.203980412966564 0.363475997320006 no 1228 0.419184402650447 1904 22310231
SGTC_3261 9137475 49.47 µM 0.203890541894088 0.363512065486135 no 1229 0.419219518154443 2058 17027690
SGTC_2853 9015042 58.44 µM 0.203641182135978 0.363612147951553 no 1230 0.419316954360448 1940 6457456
SGTC_512 prima-1 270 µM 0.201464507630816 0.364486167651419 no 1231 0.420167689618233 2022 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1688 st021091 57.6 µM 0.200776975324165 0.364762385412889 no 1232 0.420436483673209 2071 3656366
SGTC_2831 7999036 19.48 µM 0.20064820472803 0.364814127121293 no 1233 0.420486831285255 2064 2988270
SGTC_1817 st052116 64.4 µM 0.200154424111114 0.365012557441878 no 1234 0.420679905073214 2034 4361398
SGTC_2356 9061756 188.97 µM 0.198802678053496 0.365555953956061 no 1235 0.421208550512093 2062 20104043
SGTC_1833 st055984 71 µM 0.196561378012182 0.366457542024781 no 1236 0.422085398394967 1932 676288
SGTC_2930 9013230 14.89 µM 0.19638020561377 0.3665304529357 no 1237 0.422156294119917 2031 2995857
SGTC_1933 st074711 15.9 µM 0.195228407598539 0.366994094394805 no 1238 0.422607070435558 2080 17250958
SGTC_2990 9074105 71.4286 µM 0.195082069165103 0.367053014954902 no 1239 0.422664349813282 2021 6502001
SGTC_841 0251-0215 91.2 µM 0.193589600892289 0.367654109291926 no 1240 0.423248620719861 2010 3888614
SGTC_1998 st075797 76.8 µM 0.193553959886028 0.367668467743571 no 1241 0.423262575516383 2070 24208315
SGTC_725 1497-0963 19 µM 0.191843950318435 0.368357584742607 no 1242 0.423932221473426 2084 3549977
SGTC_3349 9149703 23.001 µM 0.191172248628364 0.368628389928623 no 1243 0.424195322502921 2046 4910494
SGTC_516 3992-2719 87.3 µM 0.191133045838755 0.368644197054728 no 1244 0.424210679016283 1857 5350887 YDR037W KRS1
SGTC_3116 9124943 49.47 µM 0.188996679296132 0.36950594605087 no 1245 0.42504770971359 1857 41905195 YPL160W CDC60
SGTC_2148 5546263 113.568 µM 0.187248199543028 0.370211721015347 no 1246 0.425733017660429 1974 792097
SGTC_599 1935-0052 86.5 µM 0.186002611211857 0.370714770364928 no 1247 0.426221356806472 2011 9557311
SGTC_334 1502-1024 68.5 µM 0.185888464082825 0.370760881450361 no 1248 0.426266114431263 1994 3296216
SGTC_2463 5473429 200 µM 0.18573071450659 0.370824609316227 no 1249 0.426327970343189 1957 5399405
SGTC_332 4112-0506 40.9 µM 0.185320647445819 0.370990285281306 no 1250 0.426488772099668 1972 2790355
SGTC_1626 st003712 1.76 µM 0.185107587505426 0.371076375550628 no 1251 0.426572325242183 2009 24207035
SGTC_458 nppb 133 µM 0.18491092305456 0.371155846687741 no 1252 0.426649451688455 2100 4549 A chloride channel blocker.
SGTC_2094 5332512 191.667 µM 0.183328759363059 0.371795390896997 no 1253 0.427270035038146 2060 755774
SGTC_3026 9090633 49.47 µM 0.182224815465184 0.372241838258821 no 1254 0.427703149547623 1980 25236842
SGTC_2379 9035213 200 µM 0.181422231327261 0.372566520208712 no 1255 0.428018085168033 2110 646551
SGTC_109 0132-0036 33.701 µM 0.180633632591344 0.372885632653633 no 1256 0.428327577558149 2098 67274 A color developer.
SGTC_2129 girgensonine 121.053 µM 0.177549060956544 0.374134664081764 no 1257 0.429538566122455 2009 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_205 1486-1330 71.903 µM 0.175904698661246 0.374801054769641 no 1258 0.430184406957621 2006 4118834
SGTC_2993 9054257 71.4286 µM 0.173619911316184 0.375727603254435 no 1259 0.431082091356558 2061 6470217 YGL055W OLE1
SGTC_2338 7999974 200 µM 0.173285083040784 0.375863446339844 no 1260 0.431213674163961 2113 315925
SGTC_1732 st034308 51.822 µM 0.17311231188704 0.375933547295001 no 1261 0.431281573786758 1890 830119
SGTC_3241 9133421 49.47 µM 0.17038092070766 0.377042337030531 no 1262 0.432355287912947 2107 17018221
SGTC_1754 st042065 16.137 µM 0.170090451276284 0.377160310976838 no 1263 0.432469501436729 2021 1126236 YIL048W NEO1
SGTC_1805 st050013 60.3 µM 0.168379737920582 0.37785534824595 no 1264 0.433142273657829 2067 4037144
SGTC_276 colchicine 750 µM 0.167181047371382 0.378342594161179 no 1265 0.433613798274277 2025 2833 A microtubule depolymerizer.
SGTC_3 0833-0587 95.581 µM 0.166979188139919 0.378424665327406 no 1266 0.433693212233591 2031 5382644
SGTC_1790 st045711 43.5 µM 0.166774710617923 0.378507806620123 no 1267 0.433773658990403 2123 585119
SGTC_1594 piperine 70.1 µM 0.166548134779654 0.37859993973604 no 1268 0.433862803001612 1962 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2184 6075246 200 µM 0.165024402755215 0.379219717815472 no 1269 0.434462387380336 2039 2267320
SGTC_2665 lovastatin 100 µM 0.162015976636918 0.380444305888225 no 1270 0.43564663627715 2022 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1667 st014849 34.6 µM 0.16154154722878 0.380637533447759 no 1271 0.435833445539651 2108 5348460
SGTC_2689 tacrolimus 100 µM 0.161181638692302 0.38078413834369 no 1272 0.435975171114109 1983 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1871 st057448 67.3 µM 0.160684040760175 0.380986857734672 no 1273 0.436171129859233 2091 691747
SGTC_2854 9024559 71.43 µM 0.159109728966016 0.381628440958102 no 1274 0.43679121163079 1977 3163529
SGTC_963 1269-2853 151 µM 0.158462726382294 0.38189220997148 no 1275 0.437046094780734 1986 3668223
SGTC_1623 st003709 20.3 µM 0.157520460926668 0.382276449356667 no 1276 0.437417341849237 1973 16192618
SGTC_201 4262-0159 12.803 µM 0.157433551693029 0.382311895269715 no 1277 0.437451586358737 2125 1341029
SGTC_3117 9124945 49.47 µM 0.157271706969857 0.382377906234865 no 1278 0.437515358658137 1930 17592065
SGTC_3043 9092303 49.47 µM 0.157269945489006 0.382378624701878 no 1279 0.437516052750151 1990 25236084
SGTC_1398 3558-0053 112 µM 0.157218232064358 0.382399717583813 no 1280 0.437536429937892 2021 4532369
SGTC_2878 9043973 25.97 µM 0.155661719344304 0.38303475134335 no 1281 0.438149836406661 2119 6465167
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.155526868028261 0.383089783477842 no 1282 0.438202987011405 2146 1241132 A phosphatase inhibitor.
SGTC_2353 9059630 146.67 µM 0.154106107803186 0.383669731674087 no 1283 0.438763036240714 2099 4779114
SGTC_15 0266-0086 27.098 µM 0.152735556311362 0.38422943194535 no 1284 0.439303409921188 2140 1712902 YIL048W NEO1
SGTC_1230 0170-0365 3.77 µM 0.152259911832535 0.38442373021952 no 1285 0.439490970965125 2137 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.147882711977833 0.386213150882153 no 1286 0.441217666013043 2125 66535 A nucleotide analog.
SGTC_1762 st045503 25.4615 µM 0.146177904906299 0.386910742106132 no 1287 0.441890473758795 2015 4645554
SGTC_2122 5258151 111.688 µM 0.145610870406914 0.387142848468932 no 1288 0.442114293055435 2040 2173356
SGTC_2866 9034245 58.44 µM 0.144307856736939 0.387676368752217 no 1289 0.44262868723467 2178 6462273
SGTC_342 k048-0088 23.3 µM 0.143055432596144 0.388189375081369 no 1290 0.443123201233724 2056 6820570
SGTC_1791 st048313 56.1 µM 0.142046177860766 0.388602918663869 no 1291 0.44352176540243 2167 1204976
SGTC_2802 7925815 54.55 µM 0.140915432395389 0.389066393239341 no 1292 0.443968375256385 2060 1262923
SGTC_248 streptozotocin 5.23457 mM 0.139505881790626 0.389644366640472 no 1293 0.444525204196806 2166 5300 DNA alkylating agent.
SGTC_1630 st005209 31.3 µM 0.139302807825939 0.389727655422908 no 1294 0.444605435596063 2199 3367314
SGTC_384 k007-0144 5.16 µM 0.13721874280029 0.39058270615394 no 1295 0.445428948214965 2066 6824886
SGTC_755 1995-0008 37.3 µM 0.136571149092206 0.390848509072054 no 1296 0.445684891235213 2160 689533
SGTC_2086 5274770 176.623 µM 0.135670572724405 0.391218232732891 no 1297 0.446040856073195 2057 689278
SGTC_2024 5144227 134 µM 0.135431662343771 0.39131633179089 no 1298 0.446135295903646 2130 3475211
SGTC_1977 st070720 65.3 µM 0.134838942287345 0.39155973857932 no 1299 0.446369607745292 2024 682188
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.13472159538327 0.391607933370803 no 1300 0.446415999101153 2187 4000243
SGTC_712 r015-0009 80.6 µM 0.134258474730876 0.391798154905398 no 1301 0.4465990941264 2118 6813872 YLR060W FRS1
SGTC_1675 st018485 24.5 µM 0.134072209900266 0.391874668360953 no 1302 0.446672737250349 2027 3323024
SGTC_767 0929-0023 86 µM 0.13342537913841 0.392140404531377 no 1303 0.446928487598545 2174 1204563
SGTC_325 2810-4341 181 µM 0.133067088697261 0.392287621928178 no 1304 0.447070161525456 2176 774970
SGTC_478 N-arachidonylglycine 10 µM 0.131912147685925 0.392762278676077 no 1305 0.447526890066331 2183 5283389
SGTC_700 3453-2283 142 µM 0.129816244710094 0.393624058207317 no 1306 0.448355905126952 2151 565664
SGTC_2943 9068529 45.32 µM 0.129105668341516 0.393916346845112 no 1307 0.448637018430608 2175 3270634
SGTC_657 3534-0529 86.7 µM 0.126725408018563 0.394895878196541 no 1308 0.449578867635672 2180 1049549
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.126415756758795 0.395023355737123 no 1309 0.449701415061225 2098 521171
SGTC_1986 st071812 45 µM 0.124726639692761 0.395718930647069 no 1310 0.450369983328987 2184 11838594
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.124296049423051 0.395896300061275 no 1311 0.450540437575081 2221 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2848 9016370 25.97 µM 0.123858415348428 0.396076593060288 no 1312 0.450713689542553 2187 7894410
SGTC_2862 9027634 71.43 µM 0.123772242863302 0.396112096335084 no 1313 0.450747804887356 2064 5012562
SGTC_3313 9133968 57.047 µM 0.123279900091786 0.396314959279885 no 1314 0.450942728407194 2184 1494643
SGTC_3076 9116187 49.47 µM 0.122674800790728 0.396564320426809 no 1315 0.451182309587283 2171 27241210
SGTC_3247 9135149 49.47 µM 0.121938387892637 0.396867852920515 no 1316 0.451473906658806 2186 8934436 YOR116C RPO31
SGTC_331 k048-0133 24.5 µM 0.121281835680667 0.397138521374197 no 1317 0.45173390341658 2148 6813582
SGTC_2037 5169046 200 µM 0.12095611018047 0.397272822492374 no 1318 0.451862899438024 2118 5718022
SGTC_965 1291-5240 308 µM 0.12048276432817 0.397468011226882 no 1319 0.452050366128049 2171 2834598
SGTC_433 pimozide 108 µM 0.117981410197884 0.398499894015117 no 1320 0.453041193755109 2100 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1670 st016595 4.04 µM 0.115113163525384 0.399684004465695 no 1321 0.454177713140442 2219 597879
SGTC_3272 9137413 49.47 µM 0.114149437478351 0.400082071337089 no 1322 0.454559666433529 2225 17614870
SGTC_321 4534-3890 65.3 µM 0.113672783883786 0.400278991425391 no 1323 0.454748593981426 2202 699746
SGTC_425 3825-7017 13.1 µM 0.112625469628265 0.400711757770376 no 1324 0.455163745838355 2138 3397440
SGTC_1306 1185-0270 9.02 µM 0.112331481418153 0.400833260150193 no 1325 0.455280290600588 2178 1548076
SGTC_2551 apiole 73.87 µM 0.111721558551631 0.401085365742383 no 1326 0.45552209254553 2216 10659 A possible DNA adduct former.
SGTC_629 3448-6466 76.7 µM 0.110525168005642 0.401580001514569 no 1327 0.455996445479771 2176 573744
SGTC_547 1120-0019 610 nM 0.110331284522569 0.401660175585079 no 1328 0.456073323625442 2145 3676939
SGTC_2312 7706453 155.7 µM 0.110041855068091 0.401779867217434 no 1329 0.456188090456035 2119 976098
SGTC_2523 spermine 47.74 µM 0.109506760054266 0.402001176469041 no 1330 0.456400280134155 2191 1103 A DNA binding polyamine.
SGTC_2922 7999257 32.47 µM 0.107654619201016 0.402767443202034 no 1331 0.457134834425875 2220 2988377
SGTC_2539 epi(13)torulosol 80 µM 0.106014214710656 0.403446422608059 no 1332 0.457785537018269 2109 6708597
SGTC_1521 st012942 49.4 µM 0.105473023313034 0.403670490972116 no 1333 0.458000237425024 2219 24207259
SGTC_937 3122-0005 46.7 µM 0.104914189388333 0.403901897017655 no 1334 0.45822194980185 2219 759535
SGTC_2229 7354935 190 µM 0.104451252371274 0.404093618846873 no 1335 0.458405625783227 2216 318112
SGTC_670 4204-0025 119 µM 0.103226851537988 0.404600806032553 no 1336 0.458891464649616 2170 719039
SGTC_752 1896-0090 130 µM 0.102584338899442 0.404867020147901 no 1337 0.459146436502056 2215 772567
SGTC_2324 6149169 200 µM 0.102280307264838 0.404993005808489 no 1338 0.459267092925356 2200 2888231
SGTC_939 1165-0479 45.3 µM 0.101879110593568 0.405159270116095 no 1339 0.459426315503487 2239 1377347
SGTC_2073 5212005 126 µM 0.100114632816896 0.40589070950347 no 1340 0.46012665919519 2254 691789
SGTC_439 amiodarone 34.4 µM 0.100054166990719 0.405915780597868 no 1341 0.460150661056261 2148 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1362 1611-0397 101 µM 0.0999852475217395 0.405944357317557 no 1342 0.460178018761117 2182 27816
SGTC_1038 k292-0204 154 µM 0.0993887382761109 0.406191714412482 no 1343 0.46041481202237 2225 4454212
SGTC_2679 rapamycin 1 nM 0.09800179661655 0.406766988166897 no 1344 0.460965433371703 2155 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2418 pentamidine 31.67 µM 0.0977816196076181 0.40685833142518 no 1345 0.461052851430214 2240 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1024 4507-0395 26 µM 0.0967335908887348 0.407293188971787 no 1346 0.461468981620448 2120 4201836
SGTC_1384 3089-0840 101 µM 0.0949545042867796 0.408031645067841 no 1347 0.462175481945357 2225 1069836
SGTC_902 1120-0002 2.07 µM 0.0935834329167553 0.40860096696504 no 1348 0.462720035234199 2228 3280475
SGTC_2545 solidagenone 89.61 µM 0.0935192056779297 0.408627641340381 no 1349 0.462745546316133 2268 6708572 An anti ulcer agent
SGTC_2708 st078559 56 µM 0.0926813003927375 0.408975672620403 no 1350 0.463078376592178 2239 17250902
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0919469129175784 0.409280765906718 no 1351 0.463370109090867 2173 676296 Flavone; oxidizing agent.
SGTC_3068 9116768 49.47 µM 0.090973027551374 0.409685440723779 no 1352 0.463757011530551 2161 41904888
SGTC_505 gw-5074 63.9 µM 0.0889822231718556 0.410512970945385 no 1353 0.46454801896247 2220 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1926 methyl fluorone black 53.6 µM 0.0885537572147715 0.410691126339541 no 1354 0.464718280016192 2240 72721 Reacts with homocysteine.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0877356974060826 0.411031325322967 no 1355 0.465043373291577 2221 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2349 9023730 187.07 µM 0.0853104171061022 0.412040296635941 no 1356 0.466007305036557 2230 4126287
SGTC_219 mitoxanthrone 164.414 µM 0.0850244215911827 0.412159315694884 no 1357 0.466120987692558 2215 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_159 3970-0959 50 µM 0.0849290867498714 0.412198991760333 no 1358 0.466158883719707 2211 6615653
SGTC_2572 astragaloside iv 100 µM 0.0843689106003584 0.412432141701258 no 1359 0.466381562439519 2158 45006101 An anti-inflammatory agent.
SGTC_1500 4488-1866 171 µM 0.0836486154828663 0.412731979885468 no 1360 0.466667906392956 2250 2900003
SGTC_1944 st076371 56.9 µM 0.0829102686995275 0.413039385316429 no 1361 0.466961444457265 2096 24208455
SGTC_208 k072-0098 12.366 µM 0.0813576645853043 0.413685974754234 no 1362 0.467578758110397 2281 5948901
SGTC_80 0159-0065 512.242 µM 0.0801638595321343 0.414183299903205 no 1363 0.468053466769227 2261 1548079
SGTC_591 4299-0174 154 µM 0.0796580224989336 0.414394067225181 no 1364 0.468254623251832 2213 5509088
SGTC_1045 1348-1485 165 µM 0.0796285091706581 0.414406365317385 no 1365 0.468266360083572 2269 6810614
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0779868385002274 0.415090575088977 no 1366 0.4689192612301 2199 4330530
SGTC_798 1287-0182 476 µM 0.0763109053996049 0.415789330366732 no 1367 0.469585874945212 2266 1649755
SGTC_779 1360-0071 233 µM 0.0755464068103186 0.416108165225847 no 1368 0.469889987853796 2295 7566
SGTC_4 0960-0234 25.671 µM 0.0752795877682728 0.416219455369113 no 1369 0.469996130996632 2177 6821112
SGTC_917 harmaline 728.087 nM 0.0731424884141567 0.417111080524473 no 1370 0.47084636565923 2237 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2476 5806916 10.51 µM 0.0730057326015291 0.417168151363538 no 1371 0.47090077786498 2230 2870194
SGTC_1846 st056244 14.8 µM 0.0727748710928708 0.417264498284592 no 1372 0.470992633941609 2210 5393182
SGTC_850 0388-0143 75.9 µM 0.0726567868554821 0.417313781061146 no 1373 0.471039618354979 2163 67273
SGTC_619 1652-1634 108 µM 0.0700644574921592 0.418396022717891 no 1374 0.472071177982649 2197 5400454
SGTC_3051 9093778 49.47 µM 0.0700288377906912 0.418410897498946 no 1375 0.472085353368888 2295 17217378
SGTC_1293 1000-1278 195 µM 0.069308943871239 0.418711550053096 no 1376 0.472371853339962 2247 678847
SGTC_3141 9094609 49.47 µM 0.0682478375130632 0.419154791237791 no 1377 0.472794173442585 2170 25236309 YDL196W YDL196W
SGTC_3064 1327-0027 10 µM 0.0678676148366247 0.419313641366442 no 1378 0.472945509453952 2222 16000455 YPR107C YTH1
SGTC_959 1222-0044 107 µM 0.0668296681447353 0.419747343525058 no 1379 0.473358652217715 2300 6083612
SGTC_519 k048-0011 62.8 µM 0.0652879683152664 0.420391716859762 no 1380 0.473972360899863 2186 6836379
SGTC_1627 st003713 25.6 µM 0.0641741581844957 0.42085738106043 no 1381 0.474415776875703 2223 16195070 YER133W GLC7
SGTC_1403 3909-7815 62.9 µM 0.0640349351004817 0.420915595555572 no 1382 0.474471204845544 2233 6615483
SGTC_2825 7998094 58.44 µM 0.0635259003452797 0.421128457162318 no 1383 0.474673867699572 2243 2987815
SGTC_2097 5376186 200 µM 0.0629315788584742 0.42137701204841 no 1384 0.474910494190878 2288 742755
SGTC_2783 7738165 71.43 µM 0.0616836284166253 0.421899027025574 no 1385 0.475407388885454 2214 17201110
SGTC_1011 4112-3381 17.4 µM 0.0615512781264323 0.421954396932526 no 1386 0.475460088873677 2222 2877139
SGTC_967 1306-0166 352 µM 0.0610472520489191 0.422165274787265 no 1387 0.475660788754929 2305 4437607
SGTC_896 0964-0007 44.5 µM 0.0599677018642029 0.422617019339439 no 1388 0.476090679277997 2311 6756758
SGTC_1294 1000-1494 117 µM 0.0589379144451787 0.423048035224585 no 1389 0.476500779582617 2226 712797 YDL207W GLE1
SGTC_2048 5246248 200 µM 0.0588083298424303 0.423102279189953 no 1390 0.476552386845429 2326 677046
SGTC_252 miconazole 1.30953 nM 0.0579408331433551 0.423465449804701 no 1391 0.476897878796467 2317 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.0578872179849127 0.423487897502555 no 1392 0.476919232309785 2288 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1744 st037937 38.9 µM 0.0572031768588962 0.423774314930335 no 1393 0.477191673769438 2262 1016152
SGTC_1292 0kpi-0043 232 µM 0.0569106592783139 0.423896808367156 no 1394 0.477308181600098 2230 3333905
SGTC_88 0180-0332 8.668 µM 0.0561879815152446 0.424199465380927 no 1395 0.477596027699681 2312 3101745
SGTC_1195 1502-0147 41.1 µM 0.0561064748351012 0.424233603138491 no 1396 0.477628492946636 2296 817940
SGTC_769 0302-0231 76 µM 0.0549483468729433 0.424718727648962 no 1397 0.478089807398743 2291 571869 YER009W NTF2
SGTC_234 nsc-17383 10.7 µM 0.0546372792617917 0.424849049224438 no 1398 0.478213719273357 2301 408974
SGTC_2334 9017922 200 µM 0.0542213063612335 0.425023333637539 no 1399 0.478379422815475 2295 3163164
SGTC_484 loperamide 105 µM 0.0534578630560958 0.42534323938121 no 1400 0.478683551512565 2308 3955 An opioid-receptor agonist.
SGTC_2269 7935389 174.42 µM 0.0526042428140468 0.425700990181661 no 1401 0.479023618188365 2312 97605
SGTC_3266 9136860 49.47 µM 0.0510547147056874 0.42635055089796 no 1402 0.479640960664713 2313 4871271 YPR165W RHO1
SGTC_854 0422-0053 192 µM 0.0510204180912409 0.426364930273241 no 1403 0.479654625225744 2293 3596728
SGTC_56 0957-0365 83.25 µM 0.0497972953623658 0.426877806863121 no 1404 0.480141960999593 2306 6752360
SGTC_1166 k206-0078 225 µM 0.0497240087711215 0.426908541137633 no 1405 0.480171161944474 2306 5404595
SGTC_1497 4476-2978 41.3 µM 0.0493216697017963 0.427077278394564 no 1406 0.480331475303437 2275 1528379
SGTC_3131 9127911 49.47 µM 0.0486230129983443 0.427370320192579 no 1407 0.480609864966437 2271 45595681
SGTC_3109 9122853 49.47 µM 0.0485354854073843 0.427407035246621 no 1408 0.480644742244669 2246 1234709
SGTC_2433 5607874 27.82 µM 0.0483810538859391 0.427471815914974 no 1409 0.480706279214831 2315 2252428
SGTC_2949 9072542 2.23 µM 0.0478219678020384 0.427706356723748 no 1410 0.480929064404831 2269 16457352
SGTC_1975 st070967 30.8 µM 0.047768632622905 0.427728732567912 no 1411 0.48095031777345 2331 261391
SGTC_694 1315-0438 43.2 µM 0.0476556303779872 0.427776141456707 no 1412 0.480995347863206 2274 6793154
SGTC_945 3381-0768 11.3 µM 0.0475108358851284 0.427836889968629 no 1413 0.481053047151011 2312 1126236 YIL048W NEO1
SGTC_2116 5511452 16.8835 µM 0.0467578012766941 0.428152853097522 no 1414 0.481353130962931 2277 870744
SGTC_2908 7930301 100 µM 0.0461745505579598 0.42839760887449 no 1415 0.481585563272987 2330 2223178
SGTC_2140 5586273 200 µM 0.0456928140659556 0.428599785918931 no 1416 0.481777545686785 2335 854421
SGTC_3146 9095609 49.47 µM 0.0440010793491807 0.429309927832985 no 1417 0.482451771753054 2299 17173999
SGTC_982 1491-0518 27.5 µM 0.0434604813192745 0.429536903801906 no 1418 0.482667233040682 2277 3091256
SGTC_3269 9137823 49.47 µM 0.0433761779802939 0.429572301578184 no 1419 0.482700833521045 2288 17682936
SGTC_2552 juarezic acid 87.02 µM 0.0410204762407057 0.430561655287917 no 1420 0.483639785960048 2336 1549512
SGTC_3119 9125183 49.47 µM 0.0407261578917029 0.430685294636822 no 1421 0.483757103954633 2333 22695334
SGTC_3238 9133470 49.47 µM 0.0398583808053945 0.431049876123355 no 1422 0.484103016011088 2337 3534688
SGTC_2270 7924575 90.91 µM 0.0397637008636594 0.431089657819092 no 1423 0.484140757922149 2347 1262135
SGTC_2066 5222451 176 µM 0.038751411025116 0.431515035521198 no 1424 0.484544292047252 2342 2281147
SGTC_529 4076-0302 30.3 µM 0.036777524305672 0.432344717090829 no 1425 0.485331197464039 2249 5816522
SGTC_2118 5526350 200 µM 0.0364867280118309 0.432466972476332 no 1426 0.485447130588063 2310 743594
SGTC_2195 6536160 144.242 µM 0.0359650491007525 0.432686310781898 no 1427 0.485655113845572 2344 3834386
SGTC_879 0831-1030 162 µM 0.0352793591890454 0.432974638551648 no 1428 0.485928491032389 2343 1549252
SGTC_561 1550-0330 72.9 µM 0.0339007527135304 0.433554440692647 no 1429 0.486478146477962 2318 6812934
SGTC_2781 5567276 71.43 µM 0.0337909624694352 0.433600621469181 no 1430 0.486521921368114 2328 2853274
SGTC_2654 protoveratrine a 100 µM 0.0335198167360291 0.433714676655901 no 1431 0.486630031620204 2337 5702278 A heart drug and vasodilator.
SGTC_833 3852-0053 558 µM 0.03347612064376 0.433733057568608 no 1432 0.486647454061173 2321 3123681
SGTC_973 1325-0077 65.9 µM 0.0332548604480449 0.433826133636298 no 1433 0.486735674988128 2318 2835149
SGTC_3010 9080089 71.4286 µM 0.0330829521169309 0.433898451713758 no 1434 0.48680421877418 2348 17027233
SGTC_2651 TUB2.036 5 µM 0.0321288281993699 0.434299870946501 no 1435 0.487184656847214 2329 15992207 YFL037W TUB2
SGTC_586 0957-0265 8.15 µM 0.0317950464000474 0.434440315719408 no 1436 0.487317748520483 2353 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2581 avocatin a 64 µM 0.0315999754986536 0.434522399187088 no 1437 0.487395531465271 2327 6710728 A skin care supplement.
SGTC_626 0214-0009 33 µM 0.0313119098289911 0.434643618885474 no 1438 0.487510396198007 2330 3437874
SGTC_560 2332-1943 155 µM 0.0303838096242327 0.435034210545995 no 1439 0.487880478471584 2357 21177716
SGTC_731 3966-0296 387 µM 0.0300978368723394 0.435154575186759 no 1440 0.487994512938364 2353 660956
SGTC_1764 st044502 93.5 µM 0.0299829282870494 0.435202941384694 no 1441 0.488040334151632 2320 8407
SGTC_2624 nerol 100 µM 0.0271839850832143 0.436381342878953 no 1442 0.489156494519431 2346 637566 A natural product oil.
SGTC_2661 dactinomycin 12.96 µM 0.0263220322996053 0.436744353541467 no 1443 0.4895002408822 2361 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_36 0335-0881 14.2 µM 0.0253019505606858 0.437174028882875 no 1444 0.489907059053998 2341 23828853
SGTC_247 mechlorethamine 29.705 µM 0.0251584528082814 0.437234478473229 no 1445 0.48996428815666 2358 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1574 spiramycin 23.7 µM 0.0237170948547769 0.437841743228422 no 1446 0.490539135059468 2356 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2754 granisetron 64.02 µM 0.0235687006583971 0.437904272166914 no 1447 0.490598319234623 2356 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2643 anethole 100 µM 0.0235034747321856 0.437931756939471 no 1448 0.490624333408123 2359 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1560 lithocholic acid 53.1 µM 0.0228475906463946 0.438208148708276 no 1449 0.490885923036276 2351 9903 A bile acid which acts as a detergent.
SGTC_1243 0416-0003 5.65 µM 0.0217283093026041 0.438679887189286 no 1450 0.4913323407713 2347 2141977
SGTC_2607 solasodine 47.35 µM 0.0198221405470495 0.439483471757561 no 1451 0.492092627874939 2338 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2593 nobiletin 86.24 µM 0.0185911900632398 0.440002536958058 no 1452 0.492583615466989 2354 72344 An anti-infammatory.
SGTC_632 0781-2353 4.65 µM 0.0179230560387816 0.440284317869528 no 1453 0.492850117954019 2356 6811515 YHR007C ERG11
SGTC_3075 9116269 49.47 µM 0.0171516582893833 0.440609687154555 no 1454 0.493157813802697 2348 17015205 YNL244C SUI1
SGTC_3335 9143315 29.6265 µM 0.015390523034917 0.441352669595822 no 1455 0.493860312027642 2350 4899691
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.014967258132204 0.441531266187061 no 1456 0.49402915084064 2376 23665772 A membrane-active detergent.
SGTC_2465 5809242 33.21 µM 0.014845386185862 0.441582692250897 no 1457 0.494077765311471 2379 2731748
SGTC_2809 7964133 12.99 µM 0.0144846537432381 0.441734915573488 no 1458 0.494221661259801 2361 1253665
SGTC_995 3931-2021 34.6 µM 0.0137708342663151 0.442036161320757 no 1459 0.494506405605746 2357 730143
SGTC_1645 Cervolide 78 µM 0.0123833931579517 0.442621784296518 no 1460 0.495059867155048 2364 23173 A fragrance.
SGTC_1635 st007035 42.4 µM 0.0109127903340484 0.443242645746684 no 1461 0.495646512947495 2383 3716403
SGTC_1683 st010134 710 nM 0.0102201395957561 0.443535118516393 no 1462 0.495922825181442 2385 3818134
SGTC_1466 k213-0079 57.5 µM 0.00909233300031439 0.444011402223354 no 1463 0.496372733916749 2395 3657981
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.00876029381493659 0.444151641045529 no 1464 0.49650519310872 2392 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1760 st045453 10.4495 µM 0.00845270503167183 0.444281559327621 no 1465 0.496627898734259 2380 3323419 YIL048W NEO1
SGTC_951 1171-0579 82.7 µM 0.008407342089448 0.444300720076558 no 1466 0.496645995286844 2382 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_236 1509-0011 5.31 µM 0.00664594488939101 0.445044812822876 no 1467 0.497348671107992 2390 3107280
SGTC_2900 5328528 85.29 µM 0.00620371554663062 0.44523166074243 no 1468 0.4975250914478 2386 795359
SGTC_457 grayanotoxin iii 135 µM 0.00497341440186824 0.445751543614537 no 1469 0.498015902896532 2383 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_829 1635-0120 117 µM 0.00481976995367213 0.445816475035175 no 1470 0.498077197428184 2399 285054
SGTC_722 3534-0461 190 µM 0.00458902557776891 0.445913992255535 no 1471 0.498169250096861 2395 658262
SGTC_3338 9144300 39.5675 µM 0.00358736715819539 0.446337351130748 no 1472 0.498568850634898 2400 4901274
SGTC_1142 3253-1408 9.78 µM 0.0027299667107582 0.446699786845003 no 1473 0.49891090220778 2391 256655
SGTC_636 0kpi-0074 126 µM 0.00271563859479627 0.44670584392836 no 1474 0.498916618277847 2398 616434
SGTC_2469 5655019 90.81 µM 0.00157851573072793 0.447186592019521 no 1475 0.499370263596254 2402 2788239
SGTC_1127 asiatic acid 681.4 nM 0.00154478932130383 0.447200851919661 no 1476 0.499383718470532 2401 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.000605098096618711 0.447598191175387 no 1477 0.4997586008002 2396 6708561
SGTC_1768 st044301 37.178 µM -0.000106038786743516 0.447898923442608 no 1478 0.499957696644685 2406 3931349
SGTC_14 0354-0009 295 µM -0.00115331952000973 0.448341861871001 no 1479 0.499539892182658 2411 1713507
SGTC_2815 7968870 71.43 µM -0.00130398864916858 0.448405591403032 no 1480 0.499479783942111 2410 2977326 YHR190W ERG9
SGTC_497 capsazepine 133 µM -0.00200171539331571 0.448700730897571 no 1481 0.499201431629569 2408 2733484 A calcium channel blocker.
SGTC_1914 st062367 72.6 µM -0.00276954568125472 0.449025557108187 no 1482 0.49889511254273 2408 978205
SGTC_660 4031-1742 102 µM -0.00383670081898611 0.449477067683114 no 1483 0.498469381581243 2411 6738706
SGTC_2640 pentamidine 10.38 µM -0.00452816953990389 0.449769661274031 no 1484 0.498193527891122 2416 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_448 monastrol 171 µM -0.00511261347556682 0.450016988846812 no 1485 0.497960371206831 2384 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2050 5263056 171 µM -0.00542041000147425 0.450147251354796 no 1486 0.497837579862261 2419 763468 YGL055W OLE1
SGTC_2795 7780010 54.55 µM -0.00557994410789395 0.450214769867324 no 1487 0.497773935924796 2427 953673
SGTC_3305 9127027 53.8275 µM -0.00589382390438337 0.450347615239748 no 1488 0.497648718064118 2417 41905295
SGTC_1354 1498-1681 81 µM -0.00609178726892716 0.450431403414251 no 1489 0.497569743526308 2423 5754243
SGTC_991 3996-0057 64.7 µM -0.00642049720389438 0.450570535071961 no 1490 0.497438609802119 2426 715343
SGTC_658 3253-0951 102 µM -0.00686424253414874 0.450758366904661 no 1491 0.497261584934909 2423 1184878
SGTC_2756 carbadox 75.1 µM -0.00768482204373936 0.451105736941007 no 1492 0.496934229745026 2429 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_55 0767-0285 6.563 µM -0.00784101905075068 0.45117186295 no 1493 0.496871918032492 2419 3116166
SGTC_104 0074-0074 590.992 µM -0.0081450573155145 0.451300581445491 no 1494 0.49675062818887 2419 3943124
SGTC_3347 9188721 44.724 µM -0.00983157957455478 0.452014684873224 no 1495 0.496077830410805 2439 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2620 irigenin 100 µM -0.0105456164263168 0.452317067656929 no 1496 0.495792985711819 2430 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3169 9102970 49.47 µM -0.0112642411269478 0.452621421245411 no 1497 0.495506312986869 2421 17027839
SGTC_2675 theaflavin digallate 100 µM -0.0131412467813535 0.453416505875675 no 1498 0.494757551930624 2445 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1877 wortmannin 25 µM -0.0131868536418793 0.453435826915127 no 1499 0.4947393590021 2423 312145 A covalent inhibitor of PI 3-kinase.
SGTC_39 0986-0283 58.349 µM -0.0140059932699402 0.45378286862855 no 1500 0.494412599784246 2436 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2455 5377712 9.75 µM -0.0142532032491099 0.453887610067768 no 1501 0.49431398711595 2459 2243908
SGTC_1849 st056239 19.2 µM -0.0154049493574645 0.45437564039996 no 1502 0.493854557439846 2440 5393181
SGTC_1079 idarubicin 2.36 µM -0.0166110348067288 0.454886769812024 no 1503 0.493373460635388 2432 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_275 trichlorophene 5.69 µM -0.0182245526569872 0.455570682500333 no 1504 0.492729857849906 2478 62616
SGTC_1738 st035555 74 µM -0.0199278922288326 0.456292810259605 no 1505 0.492050447389684 2461 5331140
SGTC_59 0330-0160 1.33 µM -0.0199404613264999 0.456298139445612 no 1506 0.492045434041378 2462 4293482
SGTC_2020 4017018 200 µM -0.0199539876737936 0.456303874505759 no 1507 0.492040038882994 2458 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1054 3429-0080 167 µM -0.0203404185115855 0.456467721847084 no 1508 0.491885906569389 2447 1162877
SGTC_1662 st014054 52 µM -0.0210671473007724 0.45677587613404 no 1509 0.491596045865939 2441 2838777
SGTC_3072 9116419 49.47 µM -0.0231037441626625 0.457639590752224 no 1510 0.490783759537301 2456 17170162
SGTC_2082 5219693 150 µM -0.0243481372616813 0.45816743287728 no 1511 0.49028745825736 2442 2834649
SGTC_3295 9122362 53.5725 µM -0.0248587533811468 0.45838404556206 no 1512 0.490083813545868 2462 4730473
SGTC_2218 6965428 192.983 µM -0.0258686976007197 0.458812518684166 no 1513 0.489681033691665 2451 675684
SGTC_110 0850-0284 111.64 µM -0.0268139584837291 0.459213592992468 no 1514 0.48930405998068 2450 3906265
SGTC_1557 sumaresinolic acid 42.3 µM -0.0280044469165495 0.459718776400461 no 1515 0.488829302206328 2445 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1698 5-fluorocytosine 1.055 µM -0.0280664766599476 0.459745100493207 no 1516 0.488804565642269 2458 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2830 7992007 71.43 µM -0.0297866469521363 0.460475173767163 no 1517 0.488118604115579 2455 1952075
SGTC_2105 5350118 200 µM -0.0298831794999305 0.460516148004348 no 1518 0.488080110336737 2473 2133313
SGTC_1774 st048371 48.465 µM -0.0303939403131447 0.460732952675526 no 1519 0.487876438777174 2454 4242727
SGTC_2240 6690706 185.951 µM -0.0313834082599444 0.461152989218832 no 1520 0.487481886462278 2455 805876
SGTC_1610 st001799 48.1 µM -0.0326497488062308 0.461690623418776 no 1521 0.486976948573176 2468 621897
SGTC_890 0929-0006 47.2 µM -0.0331637779516333 0.461908878309564 no 1522 0.486771991615359 2468 1378169
SGTC_3059 1327-0034 3 µM -0.0333899023390087 0.46200489353237 no 1523 0.486681830970228 2488 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_647 0140-0236 81 µM -0.0336197585173549 0.462102495589321 no 1524 0.48659018307767 2497 990837
SGTC_1795 st049545 62.3 µM -0.034443960219769 0.46245248872535 no 1525 0.486261564533056 2466 5291882
SGTC_1223 0764-0573 147 µM -0.0356527581482488 0.462965851239361 no 1526 0.485779620058449 2483 1609797
SGTC_1383 3049-0032 20.7 µM -0.0358440265451825 0.463047086392001 no 1527 0.485703363749476 2486 712864
SGTC_664 1222-0054 14.9 µM -0.0361047343490859 0.463157816199699 no 1528 0.485599423663073 2490 6813991
SGTC_2354 9060492 162 µM -0.0362405283269295 0.463215492785282 no 1529 0.485545285134547 2479 6471895
SGTC_2946 9065502 71.43 µM -0.0372021581858325 0.463623953623241 no 1530 0.48516190891084 2467 16489101
SGTC_1845 st056753 3.01 µM -0.0373912839019577 0.463704290979985 no 1531 0.485086511125591 2459 5375839
SGTC_3326 9140064 16.379 µM -0.037424450069206 0.463718379550965 no 1532 0.48507328899362 2482 1868434
SGTC_795 0685-0265 78 µM -0.0376237346375065 0.463803034088191 no 1533 0.484993841906352 2469 302754
SGTC_1192 1488-0095 21.4 µM -0.0379350652638469 0.463935288199551 no 1534 0.484869727561585 2528 915875
SGTC_3206 9114350 49.47 µM -0.0383294099876821 0.464102812648347 no 1535 0.484712521115166 2460 17087243
SGTC_1405 3909-7894 12 µM -0.0384540203117775 0.464155750590694 no 1536 0.484662845410936 2505 7104060
SGTC_3324 9138759 60.749 µM -0.0389260409893519 0.464356283890754 no 1537 0.484474677296055 2548 45595710
SGTC_2890 9046729 58.44 µM -0.0400093475267274 0.464816550075459 no 1538 0.484042837006343 2510 903329
SGTC_881 0833-0569 170 µM -0.0400693218452306 0.4648420328413 no 1539 0.48401892988597 2473 5418700
SGTC_992 3909-8734 162 µM -0.0403100032072816 0.464944298508866 no 1540 0.483922989428015 2501 4288319
SGTC_1395 3486-0190 4.35 µM -0.0408994595807142 0.465194768672259 no 1541 0.48368802414029 2461 6748079
SGTC_2873 9040596 71.43 µM -0.0424226801002113 0.465842074919531 no 1542 0.483080874258276 2572 6463863
SGTC_2863 9028737 58.44 µM -0.0432845973160218 0.466208394535567 no 1543 0.482737334638154 2505 6460917
SGTC_2821 7996764 71.43 µM -0.0440108601906493 0.466517082539636 no 1544 0.482447873538178 2524 2987135
SGTC_1407 3909-7909 12.3 µM -0.0444016827991608 0.466683204639419 no 1545 0.482292110146853 2499 4411780
SGTC_1930 st074634 34.3 µM -0.0449652152837833 0.466922748586482 no 1546 0.482067517539272 2490 684253 YOR116C RPO31
SGTC_733 4069-0007 56.1 µM -0.0452811065659873 0.467057031530053 no 1547 0.481941623383099 2481 5717425 YNL287W SEC21
SGTC_707 0865-0008 204 µM -0.0457287522433167 0.467247328666935 no 1548 0.481763223399211 2505 723043
SGTC_1133 3473-0247 50 µM -0.0466253286412735 0.467628491690052 no 1549 0.481405922321504 2559 711311
SGTC_1343 1487-0095 224 µM -0.0469989097531869 0.467787321633602 no 1550 0.481257048230507 2484 4560101 YGL055W OLE1
SGTC_1807 st050092 58.9 µM -0.0473147586608905 0.467921610433497 no 1551 0.481131182773086 2492 5008496
SGTC_543 3844-1095 191 µM -0.0477378758119775 0.468101511959514 no 1552 0.480962573983402 2553 4230703
SGTC_1121 fusaric acid 630.51 nM -0.0478735796713907 0.468159212092621 no 1553 0.480908497804143 2521 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2808 7946468 45.46 µM -0.0483570128067496 0.468364769200047 no 1554 0.480715859004966 2540 2970879
SGTC_160 3453-0671 289.699 µM -0.0485352665943719 0.468440565335263 no 1555 0.480644829435674 2510 5322268
SGTC_794 k038-0031 316 µM -0.0496011876305572 0.468893834434283 no 1556 0.480220100103222 2476 6624242
SGTC_1231 0242-0792 125 µM -0.0496718101003595 0.468923867154513 no 1557 0.480191960500361 2475 3707635
SGTC_2483 5729050 27.16 µM -0.0502841967236279 0.469184296427771 no 1558 0.479947958512749 2508 2865180
SGTC_1268 0828-0275 2.46 µM -0.0504232913731607 0.469243450963202 no 1559 0.479892538079912 2566 745337
SGTC_2058 5236698 133 µM -0.0509291544507315 0.469458591447395 no 1560 0.479690986878309 2527 766665
SGTC_1825 st052143 62.6 µM -0.0523034935292269 0.470043134324467 no 1561 0.479143434847722 2520 674173
SGTC_1010 4112-3296 15.2 µM -0.0524621130327771 0.470110603587859 no 1562 0.479080241580666 2505 704384
SGTC_170 4197-0004 226 µM -0.0528237743091403 0.47026444046071 no 1563 0.478936159391518 2559 218692
SGTC_50 0929-0078 56.389 µM -0.053215081662442 0.470430892638731 no 1564 0.47878026960645 2599 1377751
SGTC_1355 1499-0035 1.68 µM -0.0539145430876995 0.470728438560241 no 1565 0.478501624905121 2505 1548538
SGTC_2186 6124449 200 µM -0.054445645326878 0.470954376604345 no 1566 0.478290056524829 2534 3834182 YLR033W RSC58
SGTC_1443 4112-3303 14 µM -0.0558925237494595 0.47156994538794 no 1567 0.477713713352454 2512 704433
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.0560763890149334 0.471648175043128 no 1568 0.477640476585751 2494 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2845 9003024 42.97 µM -0.0563855585794333 0.471779720724249 no 1569 0.477517330618125 2595 2990173
SGTC_979 1426-2828 121 µM -0.057351239824053 0.472190619211541 no 1570 0.477132702005612 2584 747872
SGTC_351 caspofungin 25 nM -0.0576852367333916 0.472332742194247 no 1571 0.476999676746576 2534 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1964 st076914 61 µM -0.0581548717396018 0.472532588105842 no 1572 0.476812633491295 2495 24208661
SGTC_49 0717-0965 32.132 µM -0.0584479170494268 0.472657292510701 no 1573 0.476695923847305 2761 5889349 YGL099W LSG1
SGTC_1866 st057638 64 µM -0.0593243545849273 0.473030273379454 no 1574 0.476346881559835 2538 688802
SGTC_3106 9121286 49.47 µM -0.0603700473633559 0.473475314214214 no 1575 0.475930456936736 2689 15943471
SGTC_2286 7945697 125 µM -0.0607449292219057 0.473634869869237 no 1576 0.475781174689811 2543 1245733
SGTC_793 0488-0545 106 µM -0.0611611660183082 0.473812031794901 no 1577 0.475615428416829 2507 292548
SGTC_472 calcifediol 10 µM -0.0616410964895682 0.474016309942001 no 1578 0.475424324442214 2580 5283731 A vitamin D metabolite.
SGTC_1934 st074720 32.6 µM -0.062856233457241 0.474533552637994 no 1579 0.474940493265522 2514 17250992
SGTC_704 1310-0270 142 µM -0.0630679091560979 0.474623660236435 no 1580 0.474856214096024 2576 5718033
SGTC_123 0083-0120 66.675 µM -0.0645318516985469 0.475246876866958 no 1581 0.474273372985051 2521 16001701
SGTC_155 k072-0202 43.6 µM -0.0665281813215991 0.476096833918378 no 1582 0.473478660977026 2506 5857737
SGTC_566 0958-0068 16.5 µM -0.0680488860582263 0.476744362171289 no 1583 0.472873359497972 2562 6815365
SGTC_1275 0867-0008 21.1 µM -0.0691958421775703 0.477232785989381 no 1584 0.472416866319271 2547 3422836
SGTC_1511 0906-3109 28.5 µM -0.0692691950137018 0.477264023989905 no 1585 0.472387672819751 2521 2882180
SGTC_2450 5739737 12.93 µM -0.0698894597107435 0.477528175156311 no 1586 0.472140821273877 2577 2262825
SGTC_2441 5730946 39.09 µM -0.069934764852823 0.477547469575357 no 1587 0.472122791253764 2614 1774275
SGTC_3285 9112818 20.8695 µM -0.0704444967227405 0.477764556283298 no 1588 0.471919937964233 2505 17017947 YPR165W RHO1
SGTC_2088 5278280 127.392 µM -0.0705103787013293 0.47779261485451 no 1589 0.471893720051478 2571 791502
SGTC_3086 9117350 49.47 µM -0.0711821177655095 0.478078709035638 no 1590 0.471626406633412 2540 2679265
SGTC_1369 1866-0067 208 µM -0.0724438186159424 0.478616098812244 no 1591 0.471124357083122 2512 3531355
SGTC_3252 9135871 49.47 µM -0.0729372611011265 0.478826278870621 no 1592 0.470928021411092 2641 17682838
SGTC_2726 cimetidine 79.27 µM -0.0734385757354885 0.479039818072353 no 1593 0.470728560728464 2539 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1781 st038725 66.3 µM -0.0738534404023321 0.47921653773273 no 1594 0.470563501898521 2539 4270275 YIL048W NEO1
SGTC_2762 leflunomide 42.06 µM -0.0777541209348492 0.480878303396491 no 1595 0.469011821047609 2559 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_156 3474-0145 5.642 µM -0.077923792609808 0.48095059457674 no 1596 0.468944336593634 2526 2265471
SGTC_2986 9022445 71.43 µM -0.0779949393433677 0.480980907903903 no 1597 0.468916039275078 2531 6459286
SGTC_1714 st033236 13.627 µM -0.0783764951703498 0.481143478400496 no 1598 0.46876428507107 2619 2916566
SGTC_2370 9071495 200 µM -0.0808026862995702 0.48217728428938 no 1599 0.46779943584985 2608 21791103
SGTC_3193 9111931 49.47 µM -0.0810668632407019 0.48228985808116 no 1600 0.46769438911392 2570 17087244
SGTC_1494 4358-1428 177 µM -0.0811642081198087 0.482331340037472 no 1601 0.46765568167782 2549 1564571
SGTC_1501 4491-0275 38.4 µM -0.0815619232685443 0.48250082194094 no 1602 0.46749754060061 2546 5104718
SGTC_3199 9111318 49.47 µM -0.0816802217492885 0.482551234139206 no 1603 0.467450503277514 2616 8548020
SGTC_2718 lomofungin 53.02 µM -0.0820917074892891 0.482726588522583 no 1604 0.467286893666414 2608 5351222 A RNA synthesis inhibitor.
SGTC_2311 7694451 200 µM -0.0827758589567212 0.483018146610154 no 1605 0.467014882499621 2608 2163142
SGTC_10 0279-0212 42.575 µM -0.0842334223403448 0.483639332118901 no 1606 0.466435422710431 2576 39851 YBR002C RER2
SGTC_2065 5221596 34.26 µM -0.08442564894732 0.483721258402039 no 1607 0.466359007585206 2663 788581
SGTC_1880 MG-132 525 µM -0.0848237154663257 0.483890915090907 no 1608 0.466200769634647 2593 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1242 0402-0103 60.1 µM -0.0851339402639359 0.484023135498903 no 1609 0.466077453907923 2560 432868
SGTC_1136 pergolide 1.05886 µM -0.0863512747771836 0.484541990504457 no 1610 0.465593589639406 2584 47811 A dopamine receptor agonist.
SGTC_3145 9085516 49.47 µM -0.0864177636358961 0.484570330294523 no 1611 0.465567163207456 2632 25236195
SGTC_2402 5553605 200 µM -0.0865323337852186 0.484619164132184 no 1612 0.465521626908258 2647 6758546
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0879380434130026 0.485218345699831 no 1613 0.464962959721436 2555 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2748 diazoxide 86.69 µM -0.0888722662427083 0.485616575290088 no 1614 0.46459171232375 2636 3019 A potassium channel activatior.
SGTC_2190 6049624 200 µM -0.0894127805738391 0.485846985998787 no 1615 0.464376933362669 2545 2265554
SGTC_2980 9014342 25.29 µM -0.0909133752748394 0.486486684758259 no 1616 0.463780711137093 2726 2996599
SGTC_136 0097-0015 404.482 µM -0.0913039864356761 0.486653206827143 no 1617 0.463625525252127 2544 4861337
SGTC_2985 9022375 71.43 µM -0.091790128796755 0.486860458202047 no 1618 0.463432393515319 2762 4939335
SGTC_2327 6189656 200 µM -0.0922663235838558 0.487063472185278 no 1619 0.463243222046283 2646 5349088
SGTC_2142 5622915 118.518 µM -0.0929483154982727 0.487354228558359 no 1620 0.462972310819208 2614 5322196
SGTC_2325 6158266 200 µM -0.0936242308848206 0.487642400933389 no 1621 0.46270383034651 2645 3623240
SGTC_420 mitomycin C 81.9 mM -0.0939166235222913 0.487767062747209 no 1622 0.462587694271427 2574 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1252 0493-0875 34.8 µM -0.0939213633081206 0.487769083568225 no 1623 0.462585811691705 2574 3960963
SGTC_1867 st057372 64 µM -0.0943044375985988 0.487932409402869 no 1624 0.462433662466806 2563 688837
SGTC_2150 5556613 200 µM -0.0943612556926816 0.487956634283387 no 1625 0.462411095956633 2609 743190
SGTC_1218 1348-1416 30.7 µM -0.0953183273308171 0.488364696571623 no 1626 0.462030992913697 2563 6787668
SGTC_930 2810-3379 265 µM -0.0957922506395214 0.488566765636415 no 1627 0.461842786075069 2693 1015764
SGTC_1899 st063254 59.6 µM -0.0961144056875958 0.488704126183332 no 1628 0.461714855096656 2560 3093813
SGTC_3156 9099931 49.47 µM -0.0970395391208033 0.489098592191259 no 1629 0.461347497462006 2602 18111053
SGTC_3320 9137005 35.139 µM -0.0971033139513326 0.489125785425729 no 1630 0.461322174574219 2634 4908713
SGTC_1503 4585-0012 61.3 µM -0.0976229184749831 0.489347343788848 no 1631 0.461115862559336 2762 2922052
SGTC_2192 5915882 198.485 µM -0.098052495836955 0.489530517229697 no 1632 0.460945304255387 2574 2876149
SGTC_1680 diphenhydramine 100 µM -0.0980792862998768 0.48954194085977 no 1633 0.460934667675741 2650 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2173 5763948 167 µM -0.0996241746123744 0.490200705636868 no 1634 0.460321350367891 2586 2867177
SGTC_3192 9110362 49.47 µM -0.0999728140533027 0.490349374762191 no 1635 0.460182954268436 2570 16649480
SGTC_1056 3448-1962 115 µM -0.0999881640841175 0.490355920454339 no 1636 0.460176861022713 2670 715507
SGTC_2199 6590217 200 µM -0.100116095269013 0.490410474071253 no 1637 0.460126078677797 2617 703109
SGTC_1228 0124-0032 52.5 µM -0.100652942569382 0.490639403481144 no 1638 0.459912983986649 2639 X1228
SGTC_3223 9129970 49.47 µM -0.101267330661509 0.490901402623554 no 1639 0.459669124599506 2614 17248386
SGTC_1066 ketoconazole 628 nM -0.101297651179946 0.490914332582566 no 1640 0.459657090345851 2705 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_395 anisomycin 6.25 µM -0.102132094822648 0.491270178552003 no 1641 0.45932591311027 2627 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2642 cholecalciferol 100 µM -0.102399427236954 0.491384183135201 no 1642 0.45921981914117 2621 9821465 A vitamin D precursor, similar to steriods.
SGTC_2594 a-mangostin 100 µM -0.102911292614375 0.49160247137408 no 1643 0.459016687540071 2710 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1588 farnesol 29.9 µM -0.10326398333134 0.491752880036136 no 1644 0.458876729950079 2594 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_580 1123-0028 41 µM -0.104270255222832 0.492182021630357 no 1645 0.458477441055462 2580 1677248 YPR107C YTH1
SGTC_1783 st039459 87.517 µM -0.104315591995402 0.492201356477263 no 1646 0.458459452397978 2799 729761
SGTC_3127 9126946 49.47 µM -0.104983306134233 0.492486119706728 no 1647 0.458194527643344 2697 27243249
SGTC_3240 9133527 49.47 µM -0.10635576416273 0.493071450284319 no 1648 0.457650044514921 2590 17617455
SGTC_2691 st077356 60.2 µM -0.106864862901586 0.493288576310031 no 1649 0.457448094430438 2715 2839272
SGTC_1803 st050068 52.4 µM -0.107322818943161 0.493483892136742 no 1650 0.457266441096308 2576 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3164 9100705 49.47 µM -0.107777690903892 0.493677894165817 no 1651 0.457086019934808 2740 17174235
SGTC_2074 5212007 75.395 µM -0.108842312689353 0.494131959104691 no 1652 0.456663781242411 2587 758611
SGTC_558 k064-0027 21.3 µM -0.108988210758353 0.494194185750202 no 1653 0.456605920541166 2686 5088526
SGTC_637 1181-0519 7.26 µM -0.109008632519137 0.494202895799124 no 1654 0.456597821690357 2600 6252091 YGR060W ERG25
SGTC_974 1326-0144 138 µM -0.109538293662295 0.494428801585908 no 1655 0.456387775269094 2611 5411856
SGTC_3253 9135987 49.47 µM -0.110292978269215 0.494750685204345 no 1656 0.456088512910356 2689 4182430
SGTC_108 0509-0257 621.132 µM -0.111229026717217 0.495149927781518 no 1657 0.455717367225633 2688 536624
SGTC_1731 st035964 63 µM -0.111537520994159 0.495281507578517 no 1658 0.455595056879193 2673 6739575
SGTC_929 2805-0021 398 µM -0.112123596759565 0.495531483570173 no 1659 0.455362703943687 2695 3098024
SGTC_1163 k060-0048 49.9 µM -0.112223041658385 0.495573899486836 no 1660 0.45532327998383 2601 6809982
SGTC_359 0081-0058 15.9 µM -0.113994566246815 0.496329510174604 no 1661 0.454621050436444 2876 3494159
SGTC_2038 4100038 30.985 µM -0.114734682635745 0.496645197036809 no 1662 0.454327711339648 2701 3596803
SGTC_1453 4237-0541 195 µM -0.115122746333608 0.496810721329427 no 1663 0.454173915400726 2619 739892
SGTC_2205 7238770 200 µM -0.115820064500606 0.497108156067585 no 1664 0.45389757417939 2702 279867
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.116208529138121 0.497273852842407 no 1665 0.4537436386392 2710 5377381
SGTC_2773 thioridazine 9.09 µM -0.116762719122874 0.497510239369622 no 1666 0.453524043721794 2587 5452 An antipsychotic.
SGTC_1185 1319-0113 81.3 µM -0.116793687292755 0.497523448689625 no 1667 0.453511773163097 2703 4672763
SGTC_202 3594-0513 34.79 µM -0.117414379736801 0.497788202541089 no 1668 0.453265844753987 2577 708429
SGTC_452 diindolylmethane 8 µM -0.11770613438951 0.497912649651805 no 1669 0.453150253016934 2700 3071 Inhibits expression of several cancer promoting factors.
SGTC_1477 0139-0234 16 µM -0.118220067191404 0.498131866701681 no 1670 0.452946645067016 2603 620880
SGTC_1646 st011709 75.6 µM -0.119190154473881 0.49854565705332 no 1671 0.452562353318509 2625 5757843
SGTC_289 k017-0060 526 µM -0.119883159142468 0.498841258908232 no 1672 0.452287852655342 2633 5512909
SGTC_2098 5376439 882.5 nM -0.120587796586324 0.499141823386775 no 1673 0.452008767607084 2723 2844116
SGTC_1029 k015-0030 64.7 µM -0.120642070775963 0.4991649741708 no 1674 0.451987272264867 2731 2208316
SGTC_2904 7225135 42.03 µM -0.120780932233304 0.499224205866647 no 1675 0.45193227669913 2704 4446116
SGTC_1432 4049-0298 68.4 µM -0.120809062683103 0.499236204981257 no 1676 0.451921135851022 2695 741646
SGTC_2895 9054447 58.44 µM -0.121079975296348 0.499351763476378 no 1677 0.451813844935263 2624 2697450
SGTC_344 k064-0035 6.43 µM -0.122406690313632 0.499917677896207 no 1678 0.451288470126599 2641 5088750
SGTC_893 0958-0369 48.9 µM -0.122792677711608 0.499917677896207 no 1679 0.451135636359586 2778 6819948
SGTC_365 0121-0052 13.6 µM -0.122992185065961 0.499832577374793 no 1680 0.451056643197734 2717 3101739
SGTC_577 r071-0003 38.6 µM -0.123929264544087 0.499432863191921 no 1681 0.450685640899968 2624 4568517 YMR134W ERG29
SGTC_1329 1447-1697 50.6 µM -0.124047482550148 0.499382436963754 no 1682 0.450638839864093 2752 2840515
SGTC_2233 sulbentine 40.3845 µM -0.124512684432425 0.499184003875509 no 1683 0.450454678904586 2624 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_489 paxilline 115 µM -0.125603334070994 0.498718785277097 no 1684 0.450022961826636 2684 105008 A toxic potassium channel blocker.
SGTC_1255 0566-0045 221 µM -0.125624040456375 0.498709952945388 no 1685 0.450014766089212 2749 2788469
SGTC_2774 tamoxifen 10.92 µM -0.125905819896989 0.498589759676315 no 1686 0.449903237864628 2610 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3148 9097893 49.47 µM -0.126979562666442 0.498131755017336 no 1687 0.449478287113806 2657 17174100
SGTC_544 k015-0020 52.4 µM -0.127190632322372 0.498041723588954 no 1688 0.449394759744368 2673 3008304
SGTC_538 2922-0838 53.3 µM -0.127332585056963 0.497981173930022 no 1689 0.449338585528758 2624 777039
SGTC_1728 st035614 33.7865 µM -0.127598782386562 0.497867628110638 no 1690 0.449233247385473 2763 15945546
SGTC_1123 mangostin 811.285 nM -0.128599937363432 0.497440589528029 no 1691 0.448837107936912 2722 5281650 An antioxidant.
SGTC_3091 9116372 49.47 µM -0.128783894303778 0.497362123747934 no 1692 0.448764324939843 2790 17169793
SGTC_2409 alverine citrate 63.97 µM -0.129025304500537 0.497259151765442 no 1693 0.448668813042962 2923 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1906 st060206 94.7 µM -0.129662994380774 0.496987150103185 no 1694 0.448416530772967 2662 5133468
SGTC_454 lyso-paf C-16 6.67 µM -0.129805369697104 0.496926421205346 no 1695 0.448360207229275 2693 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2381 9035592 200 µM -0.130461468109029 0.496646569329993 no 1696 0.448100668771362 2673 4749657
SGTC_1492 4158-0558 28.5 µM -0.130975423488083 0.496427348215673 no 1697 0.447897374559268 2751 3967268
SGTC_1853 st056710 91.2 µM -0.131668122967404 0.496131887803286 no 1698 0.447623400070204 2822 269167
SGTC_2315 7733312 200 µM -0.132092321413073 0.495950953454447 no 1699 0.447455634659134 2672 726316
SGTC_192 3455-0609 60.9 µM -0.132172848553665 0.495916606118962 no 1700 0.447423788198991 2746 3769639
SGTC_682 0kpi-0099 17 µM -0.132317142418714 0.495855060363777 no 1701 0.447366724450005 2740 1714895 YML126C ERG13
SGTC_1837 st055472 66.5 µM -0.132774664880935 0.495659913672672 no 1702 0.447185795713784 2786 676091
SGTC_2797 7859098 81.82 µM -0.132788180517804 0.495654148874416 no 1703 0.447180451078456 2676 972681
SGTC_2837 9008476 45.46 µM -0.132843497794193 0.495630554513782 no 1704 0.447158576466018 2837 2992805
SGTC_1250 0485-0349 40.2 µM -0.133122082285368 0.495511730695328 no 1705 0.447048415717944 2679 6842794 YDL195W SEC31
SGTC_1172 0370-0043 85 µM -0.133316153424654 0.495428954341401 no 1706 0.446971676523483 2784 376585
SGTC_3354 9151612 71.43 µM -0.134720672280928 0.494829896856338 no 1707 0.446416364038863 2753 27261949
SGTC_3082 9117008 49.47 µM -0.135028073811097 0.494698785003724 no 1708 0.44629483895129 2689 41448529
SGTC_638 3970-0837 4.09 µM -0.13515633625621 0.494644079111427 no 1709 0.446244134432662 2684 4118451 YLR208W SEC13
SGTC_1409 3909-8004 61.9 µM -0.13516655781477 0.494639719464866 no 1710 0.446240093699171 2675 2119279
SGTC_173 1273-0061 2.693 µM -0.135381348718791 0.494548108102606 no 1711 0.446155184965412 2750 2847414 YPL266W DIM1
SGTC_320 4092-0846 5.34 µM -0.136674637390895 0.493996508418011 no 1712 0.445643988901965 2746 1359356
SGTC_2770 toltrazuril 17.5 µM -0.137030883318625 0.493844568177853 no 1713 0.445503192002424 2638 68591 Kills coccidiodes.
SGTC_775 4577-0580 57.3 µM -0.137047969492387 0.493837280882167 no 1714 0.445496439311039 2859 2006902
SGTC_998 3996-0085 177 µM -0.13736938408811 0.493700197142076 no 1715 0.445369414781052 2710 715391
SGTC_75 0159-0059 199.013 µM -0.137472334029455 0.493656289015695 no 1716 0.445328729674877 2913 5377270
SGTC_1708 st033234 31.827 µM -0.137642429823121 0.493583743367343 no 1717 0.445261510253158 2751 674664
SGTC_1266 0828-0227 32.9 µM -0.138650202038505 0.493153934181625 no 1718 0.444863285453427 2761 3913820
SGTC_2522 biochanin a 4.94 µM -0.139907472781724 0.492617726476749 no 1719 0.444366548469447 2760 5280373 A possible chelator.
SGTC_1434 4073-0095 163 µM -0.140125896010492 0.492524573475967 no 1720 0.444280260194418 2663 24133745
SGTC_223 busulfan 5 mM -0.140354554889996 0.492427055618177 no 1721 0.44418993114677 2757 2478 A DNA alkylator.
SGTC_3219 9131112 49.47 µM -0.14057125986205 0.492334636250089 no 1722 0.444104327027578 2674 17612988 YMR079W SEC14
SGTC_1454 4239-0054 42.6 µM -0.140710973973819 0.492275051817895 no 1723 0.444049137689709 2830 1340767
SGTC_810 3825-7150 143 µM -0.140914190062839 0.492188385753271 no 1724 0.443968865978964 2686 22330411 YGL099W LSG1
SGTC_1718 roemerine 11.9335 µM -0.141226428195436 0.49205522550992 no 1725 0.443845534314075 2714 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2030 5175110 200 µM -0.141329988014726 0.49201106053301 no 1726 0.443804630181037 2774 2831986
SGTC_271 rotenone 740 µM -0.144320430007724 0.49073577632682 no 1727 0.442623723187473 2796 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2712 st079126 47.7 µM -0.144827504815844 0.490519541574419 no 1728 0.442423532733454 2645 3152970
SGTC_2596 sinensetin 100 µM -0.145161188698306 0.490377248402315 no 1729 0.442291804117426 2716 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_644 1498-1197 63.3 µM -0.145562297377151 0.490206204825186 no 1730 0.442133466614037 2759 6741615
SGTC_1455 4262-0120 131 µM -0.145651666056397 0.490168095850173 no 1731 0.442098189619216 2851 1529587
SGTC_3229 9132204 49.47 µM -0.146202525034682 0.4899331981999 no 1732 0.44188075614579 2653 17682924
SGTC_1324 1418-0026 34.4 µM -0.146241789517834 0.489916455145335 no 1733 0.441865258449588 2759 1372513
SGTC_3110 9122132 49.47 µM -0.146451444704983 0.489827054849702 no 1734 0.44178250902885 2809 918317
SGTC_1634 st006576 41 µM -0.14777705152485 0.489261807101867 no 1735 0.441259360349711 2757 3915356
SGTC_1338 1486-1223 76 µM -0.148365966902156 0.489010696438154 no 1736 0.441026978628812 2742 3444526
SGTC_1518 st038567 90.8 µM -0.148962835753118 0.488756198896952 no 1737 0.440791479242091 2644 77966
SGTC_699 0375-0592 111 µM -0.149336286942168 0.488596966222242 no 1738 0.44064414172699 2679 762578
SGTC_2009 4012297 12.05 µM -0.151024535554859 0.487877151314375 no 1739 0.439978180654268 2776 45595307
SGTC_2052 5265182 7.135 µM -0.151370952253863 0.487729455181945 no 1740 0.43984155107461 2800 1239884
SGTC_255 tunicamycin 200.472 nM -0.151560058700508 0.487648829607799 no 1741 0.439766968967159 2778 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_801 0866-0028 10.1 µM -0.151746105171181 0.487569509147649 no 1742 0.439693595776312 2658 6849771
SGTC_1483 3453-0561 55.9 µM -0.15188769878994 0.487509141382122 no 1743 0.439637755333128 2768 4546991
SGTC_1055 3448-0672 86 µM -0.153181254151818 0.486957653633432 no 1744 0.439127670109857 2819 748378
SGTC_2646 retinol 96.75 µM -0.153222451531272 0.486940090158492 no 1745 0.439111426481809 2759 445354 A vitamin A analog and teratogen.
SGTC_1036 k216-0215 33.5 µM -0.153803059720498 0.486692565051941 no 1746 0.438882510618648 2663 622330
SGTC_535 2293-4129 48.2 µM -0.155359892773486 0.486028880952194 no 1747 0.438268800563094 2810 396118 YIL048W NEO1
SGTC_1088 bifonazole 369 nM -0.156333542011314 0.485613829975065 no 1748 0.437885059334352 2647 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2343 7990716 14.84 µM -0.15656059942544 0.485517041283467 no 1749 0.437795578314607 2706 6456862
SGTC_45 0kpi-0036 14.9 µM -0.156781243077314 0.485422987429872 no 1750 0.437708627940685 2793 2795021
SGTC_2977 9011197 71.43 µM -0.157110422975881 0.485282669298017 no 1751 0.437578911626084 2910 2704722
SGTC_1649 st011737 51.3 µM -0.157760488231933 0.485005574082789 no 1752 0.437322767253721 2729 1761035
SGTC_2287 7945887 168.79 µM -0.158043385850504 0.484884989093764 no 1753 0.437211305667534 2780 1245853
SGTC_2846 9008642 19.48 µM -0.159581869780194 0.484229235460134 no 1754 0.436605230877379 2803 2992898
SGTC_2177 5811945 192 µM -0.161587741919523 0.483374329565968 no 1755 0.435815255489092 2838 5343475
SGTC_27 0485-0001 32.618 µM -0.162124150700412 0.483145724080666 no 1756 0.435604044136592 2668 2054479
SGTC_1967 st070177 51.4 µM -0.165103438321362 0.481876120919823 no 1757 0.434431283382051 2858 5729214
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.165225363332405 0.481824167232368 no 1758 0.434383301282338 2717 688669
SGTC_698 k064-0052 127 µM -0.166280007685234 0.481374783792218 no 1759 0.433968299287067 2661 5088751
SGTC_2453 5731132 22.18 µM -0.166362111821871 0.48133980024553 no 1760 0.43393599440005 2813 1362040
SGTC_469 w7 172 µM -0.167969107122584 0.480655108894542 no 1761 0.43330379134437 2705 45115570 A P450 inhibitor.
SGTC_2477 5967686 25.23 µM -0.16835229741202 0.48049185162957 no 1762 0.433153066770825 2699 776118
SGTC_858 0438-0351 2.77 µM -0.168384705507859 0.480478044391034 no 1763 0.433140319773323 2715 2799119
SGTC_65 0798-0905 34.986 µM -0.169024357279762 0.480205530121288 no 1764 0.432888741350162 3108 3602145
SGTC_1093 fluphenazine 7.97 µM -0.169614909645599 0.479953942144879 no 1765 0.432656498127569 2718 6602611 An atypical antipsychotic.
SGTC_72 0744-0168 198.391 µM -0.170291935233178 0.479665524552142 no 1766 0.432390276690386 2726 677577
SGTC_2438 5259590 200 µM -0.170970183303906 0.479376596848218 no 1767 0.432123605320467 2836 1201127
SGTC_1884 5633444 25 µM -0.171915137957456 0.478974072587992 no 1768 0.431752122700961 2870 5724239
SGTC_1440 4100-1550 40 µM -0.172898843289249 0.478555064409146 no 1769 0.43136547044135 2727 742806
SGTC_1186 1319-0216 26 µM -0.173400023140271 0.478341596500237 no 1770 0.431168503458632 2886 4565136
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.175105941299412 0.47761504043613 no 1771 0.43049819495952 2748 115019
SGTC_1196 1588-0294 184 µM -0.175662810011656 0.477377884238698 no 1772 0.430279427109571 2765 6144269
SGTC_17 0960-0276 49.807 µM -0.177056873031297 0.476784223629559 no 1773 0.429731858488261 2716 6821114
SGTC_2819 7996655 46.38 µM -0.177878982549089 0.476434153022487 no 1774 0.429409008550488 2808 6456960
SGTC_2517 totarol 10 µM -0.178031192019991 0.476369341185445 no 1775 0.429349239670169 2788 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_985 1493-0307 8.71 µM -0.178190652820257 0.476301442353159 no 1776 0.429286625110033 2811 3278274
SGTC_1786 berberine 21.6 µM -0.178401598148555 0.476211622329614 no 1777 0.429203797148577 2717 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1203 3992-3522 103 µM -0.179055809376621 0.475933068438132 no 1778 0.428946940086172 3077 5322312
SGTC_2007 4011539 71.82 µM -0.179934301839965 0.475559037292635 no 1779 0.428602072847762 2713 45595301
SGTC_2421 5690543 90.72 µM -0.180592534688535 0.475278799028214 no 1780 0.428343707995685 2810 3397993
SGTC_38 0929-0051 58.268 µM -0.180853181583116 0.475167833715954 no 1781 0.428241409222011 2840 1379719
SGTC_2884 9058502 51.95 µM -0.181074965505757 0.475073415069529 no 1782 0.42815436719655 2821 6471554
SGTC_3218 9131285 49.47 µM -0.181143754811689 0.475044130123845 no 1783 0.428127370636232 2820 17156417
SGTC_617 3770-0098 35 µM -0.181472261514995 0.474904280291937 no 1784 0.427998451880032 2739 5962639
SGTC_784 4579-0127 173 µM -0.182087838012779 0.474642229230462 no 1785 0.42775689651979 2932 1948547
SGTC_1855 st056195 39.6 µM -0.182141898050768 0.4746192163818 no 1786 0.427735684376855 2912 4028379
SGTC_76 0433-0009 400.328 µM -0.182268768664953 0.474565209089795 no 1787 0.427685903552558 2875 2841569
SGTC_3054 9094397 49.47 µM -0.182380287226781 0.474517737367478 no 1788 0.427642147436424 2759 2598354
SGTC_2669 eugenol 100 µM -0.183035911672413 0.474238655546647 no 1789 0.427384920566388 2748 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_171 k064-0041 9.68 µM -0.183138148109556 0.474195137361029 no 1790 0.427344812030441 2753 53325
SGTC_2382 9035899 200 µM -0.183231048302662 0.474155593528493 no 1791 0.427308366862154 2753 6462679
SGTC_2995 9067767 71.4286 µM -0.184481363275299 0.47362341024635 no 1792 0.426817923095091 2816 11673567
SGTC_839 0122-0028 230 µM -0.184665842752989 0.473544892479102 no 1793 0.426745569439142 2739 759448
SGTC_846 0335-0850 148 µM -0.184781414452698 0.473495703618799 no 1794 0.426700242969945 2731 6819598
SGTC_2166 5933061 31.504 µM -0.185142710171803 0.473341933940893 no 1795 0.426558551383545 3245 2877375
SGTC_2937 9044753 11.33 µM -0.186963731131422 0.472566957166003 no 1796 0.425844534918357 2726 6465530 YGL099W LSG1
SGTC_2461 5755302 26.15 µM -0.187239002962739 0.472449817956697 no 1797 0.425736622809391 2900 2788904
SGTC_2638 epoxomicin 18 µM -0.187466992342692 0.472352801131185 no 1798 0.425647250585376 2849 9915668 A protesome inhibitor.
SGTC_1380 2291-0730 164 µM -0.187608062230453 0.472292772170671 no 1799 0.425591952862536 2820 2999191
SGTC_2245 6637752 200 µM -0.18804559442406 0.472106594683463 no 1800 0.42542045474521 2912 681890
SGTC_1510 1123-0200 71.5 µM -0.188416085430344 0.471948949140287 no 1801 0.425275245582184 2947 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2104 5389443 200 µM -0.19089080378837 0.470896059564711 no 1802 0.424305572602739 2914 2244536
SGTC_777 1315-0167 517 µM -0.191129750877678 0.470794408182767 no 1803 0.424211969723393 2836 4221767
SGTC_3225 9130819 49.47 µM -0.19133802805999 0.470705805753551 no 1804 0.424130384670925 2818 4547121
SGTC_480 am 92016 50 µM -0.191444338435688 0.470660581206805 no 1805 0.424088742679721 2803 2129 K+ channel blocker.
SGTC_2759 disulfiram 3.38 µM -0.19159426862335 0.470596801388982 no 1806 0.424030016159681 2744 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_499 genistein 192 µM -0.193207819522906 0.469910450118086 no 1807 0.423398107512249 2812 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_789 1309-1135 70.6 µM -0.19404483760262 0.469554445349993 no 1808 0.423070386874263 2727 3092424
SGTC_1206 3978-0017 132 µM -0.196627628021929 0.468456074506878 no 1809 0.422059474312043 3044 3873677
SGTC_212 3807-4682 38.772 µM -0.19759667051118 0.468044035956941 no 1810 0.421680319995838 2829 3125501 YBL034C STU1
SGTC_2823 7987624 58.44 µM -0.198203924149957 0.467785848074063 no 1811 0.421442758683285 2946 2239440
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.198600168903991 0.467617382781897 no 1812 0.421287760738008 2752 17037758
SGTC_216 k038-0035 28.382 µM -0.199610669104629 0.467187790266804 no 1813 0.420892541486747 2773 4444231 YPR107C YTH1
SGTC_539 4859-0462 2.54 µM -0.200599715514227 0.466767355376245 no 1814 0.420505790268279 2936 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_786 4544-0069 423 µM -0.201222529052124 0.466502621839887 no 1815 0.420262288065542 2888 748821 YLR208W SEC13
SGTC_2432 5630864 12.22 µM -0.201586714965436 0.466347827592371 no 1816 0.42011991596755 2910 5714970
SGTC_934 2950-0684 338 µM -0.201709869099657 0.46629548308422 no 1817 0.420071773381803 2981 1121253
SGTC_3017 9080681 49.47 µM -0.201804087393719 0.466255437641804 no 1818 0.420034943007459 2839 16451914
SGTC_1570 verbenone 133 µM -0.203030911966355 0.465734033799161 no 1819 0.419555435550149 2931 29025 A natural terpanoid with antifungal properties.
SGTC_2365 9042475 200 µM -0.203793550694776 0.465409939814305 no 1820 0.419257416441783 2856 6464479
SGTC_1742 st038235 28.8875 µM -0.204415168573044 0.465145791571191 no 1821 0.419014538816487 2891 564103 YBR002C RER2
SGTC_183 3914-0051 30.55 µM -0.205138446045222 0.464838463774996 no 1822 0.41873197975301 2887 1596232
SGTC_3188 9110789 49.47 µM -0.205339672030074 0.464752964572888 no 1823 0.418653375287671 2934 849217
SGTC_2125 5246583 200 µM -0.205374465026405 0.464738181490852 no 1824 0.418639784505035 2836 835267
SGTC_3263 9137018 49.47 µM -0.206452230889778 0.464280277295742 no 1825 0.418218837562079 2813 43844957
SGTC_304 1310-0298 97 µM -0.208562827308352 0.463383697899218 no 1826 0.417394765935805 2774 1550234
SGTC_496 calpeptin 138 µM -0.20880423648342 0.463281159271477 no 1827 0.417300531999765 2839 73364 A calpain inhibitor.
SGTC_2278 7948257 134.34 µM -0.209850766341371 0.462836673661785 no 1828 0.416892074653041 2931 1247028
SGTC_1828 st055811 49 µM -0.210493452112378 0.462563733003298 no 1829 0.416641280823506 2924 5877589
SGTC_866 0495-0101 262 µM -0.211096696368452 0.46230755869961 no 1830 0.416405909032471 2773 635694
SGTC_1096 rimcazole 32.2 µM -0.211261113286352 0.462237739955107 no 1831 0.416341762593082 2761 18528119 A dopamine reuptake inhibitor.
SGTC_1344 1488-0097 29.1 µM -0.213297220574524 0.461373215231851 no 1832 0.415547570667962 2881 747966
SGTC_1265 0819-1001 68.8 µM -0.21499109301761 0.460654141232057 no 1833 0.414887131469501 2743 3106768
SGTC_3132 9126706 49.47 µM -0.216130166243973 0.460170659932003 no 1834 0.414443143052548 3001 850858
SGTC_875 0709-0210 25.7 µM -0.217414779719177 0.459625474544391 no 1835 0.413942557056977 2768 6251364
SGTC_3103 9120822 49.47 µM -0.219337666631787 0.458809550348357 no 1836 0.413193511227858 3024 17141819
SGTC_3065 9113888 49.47 µM -0.219638381878851 0.458681965701565 no 1837 0.413076398405859 2986 16648368
SGTC_2228 7354201 200 µM -0.220821574249882 0.458180013372889 no 1838 0.412615682197519 2813 753451
SGTC_782 0083-0095 30.5 µM -0.222361216003887 0.457526942489257 no 1839 0.412016350593625 2759 3591729 An indicator and reagent.
SGTC_2084 5306078 60.6385 µM -0.2234448906809 0.457067348121536 no 1840 0.411594634822826 2868 679340
SGTC_2378 9074213 121.43 µM -0.224031935495132 0.456818402053122 no 1841 0.411366226897652 2801 657714
SGTC_3227 9130768 49.47 µM -0.224293793491773 0.456707362295737 no 1842 0.411264352635542 2805 17720899
SGTC_540 1187-0821 17.3 µM -0.224566232555053 0.456591839270653 no 1843 0.411158368224612 2801 847520
SGTC_3045 9092950 49.47 µM -0.22496743538088 0.456421722903866 no 1844 0.411002303863234 2885 44120432
SGTC_1615 st002656 86.5 µM -0.225425126895562 0.456227664191217 no 1845 0.410824283101145 2777 1584458
SGTC_746 1095-0025 46.6 µM -0.226812257769435 0.455639592205868 no 1846 0.410284865882206 2988 6749286
SGTC_3283 9109332 35.8195 µM -0.227927989688396 0.455166649843099 no 1847 0.409851111372109 2781 17027281
SGTC_1777 st045864 34.765 µM -0.22911002373531 0.45466567230718 no 1848 0.409391701423604 2810 4691462
SGTC_3018 9082602 49.47 µM -0.230517643336445 0.454069179718898 no 1849 0.408844777605716 2806 17332089
SGTC_2176 5809774 33.9695 µM -0.23153784024863 0.453636925951872 no 1850 0.408448495852686 2947 2870539
SGTC_3259 9138485 49.47 µM -0.232269876951444 0.453326798440882 no 1851 0.408164203704842 3109 17646153
SGTC_1226 3909-7979 35.4 µM -0.233312335151858 0.452885209964905 no 1852 0.407759440412948 2932 6615510
SGTC_3178 9107506 49.47 µM -0.233896031589268 0.452637979780814 no 1853 0.407532847053076 2955 8897194
SGTC_1939 st074455 53.6 µM -0.235566318750307 0.451930615516452 no 1854 0.406884605860409 3060 1644229
SGTC_687 k029-0044 34.9 µM -0.235822835371136 0.451821994547274 no 1855 0.406785073884502 2961 5829338
SGTC_1411 3909-8223 150 µM -0.236194165780917 0.451664762515216 no 1856 0.406641003247525 2940 X1411
SGTC_1690 st023502 41.2 µM -0.236574696260461 0.451503642773765 no 1857 0.406493376230217 2905 24207482
SGTC_2721 ifenprodil 61.44 µM -0.237297853880293 0.45119747391462 no 1858 0.40621286345918 2977 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1041 0206-0046 107 µM -0.237811374822403 0.450980078180526 no 1859 0.406013697952555 2912 50494
SGTC_2714 st079313 56.9 µM -0.237949717284632 0.450921514314867 no 1860 0.405960046952442 2835 2939799
SGTC_1912 st060209 90.8 µM -0.238121756122767 0.450848687410998 no 1861 0.405893330524799 2890 688787
SGTC_983 1491-0821 12.2 µM -0.23817735394865 0.450825152279498 no 1862 0.405871770347726 2978 46495113
SGTC_1348 1493-0373 93.8 µM -0.238300755532255 0.450772915737866 no 1863 0.405823917698237 2889 3010129
SGTC_2657 nystatin 74.44 µM -0.238468774202615 0.450701793918864 no 1864 0.405758765703288 2881 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2439 5492030 7.2 µM -0.238862775912086 0.450535020342614 no 1865 0.405605995319793 2954 5722370
SGTC_2326 6164455 177.58 µM -0.238937421496356 0.450503425241926 no 1866 0.405577053829733 2907 2888790
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.239226017517508 0.45038127468138 no 1867 0.405465164608158 2899 6857784
SGTC_2953 9074162 66.49 µM -0.239973180365048 0.450065053929259 no 1868 0.405175524071779 2948 16451992
SGTC_2635 hydroquinidine 100 µM -0.24082950127963 0.449702673350578 no 1869 0.404843631863689 2819 442912 An experimental heart treatment.
SGTC_3008 9078912 71.4286 µM -0.241580617914079 0.449384847967814 no 1870 0.404552570985265 2866 16648731
SGTC_221 trifluoperazine 10.304 µM -0.243075427319812 0.448752435321129 no 1871 0.40397348328548 2843 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1887 st057648 70.8 µM -0.245305731299506 0.447809097712753 no 1872 0.403109857184788 2985 688672
SGTC_1007 4101-0031 70 µM -0.245615427405038 0.447678130717332 no 1873 0.402989972834921 3012 1146276
SGTC_2487 5918373 44.05 µM -0.24567672126488 0.447652210909978 no 1874 0.402966246866982 2859 2876279
SGTC_3344 9148862 3.898 µM -0.246130920135219 0.447460147302648 no 1875 0.402790444182236 2999 4905352
SGTC_3134 9127454 49.47 µM -0.24666333516885 0.447235024710948 no 1876 0.402584392090972 2884 24262820
SGTC_869 0564-0080 44.1 µM -0.247560486553686 0.446855718083767 no 1877 0.402237243153383 2877 6843321
SGTC_1202 1988-0068 29.6 µM -0.248212383005312 0.446580133262079 no 1878 0.401985042922075 2845 2850480
SGTC_128 0906-2981 13.371 µM -0.248526037801129 0.446447546999705 no 1879 0.401863713318906 3004 6740226
SGTC_2264 7948757 110.76 µM -0.248948305535878 0.446269057989121 no 1880 0.401700384424504 2806 2971411
SGTC_71 0417-1750 47.813 µM -0.249757000717213 0.445927259774293 no 1881 0.401387637245298 3060 6811472
SGTC_3079 9117512 49.47 µM -0.251980702403082 0.444987611359374 no 1882 0.400527989939401 2818 7185044
SGTC_1860 st056228 74.6 µM -0.252014864045099 0.444973178396778 no 1883 0.400514787343604 2964 688679
SGTC_3014 9081533 49.47 µM -0.252295932167236 0.444854432610599 no 1884 0.400406166061208 3002 21367265
SGTC_2255 7941087 197.44 µM -0.252569778045155 0.44473874284072 no 1885 0.400300343287416 3010 935561
SGTC_521 r062-0005 13.8 µM -0.253317450781819 0.444422902721262 no 1886 0.40001145600859 2826 2832033
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.253480356437815 0.444354091001957 no 1887 0.399948519450834 2843 1377
SGTC_1525 8-methoxypsoralen 92.5 µM -0.253951003780586 0.444155297924655 no 1888 0.399766705356178 3111 4114 Related to psoralen; DNA damaging agent.
SGTC_3025 9087895 49.47 µM -0.254051720228396 0.444112758909365 no 1889 0.399727800766059 2980 17173641
SGTC_20 0481-0013 4.944 µM -0.254254647460318 0.444027051680698 no 1890 0.399649417379709 2869 182045
SGTC_1892 st058411 7.36 µM -0.254268477627864 0.444021210542497 no 1891 0.399644075437716 2987 3934738
SGTC_2843 9000894 45.46 µM -0.254392966873224 0.443968633354821 no 1892 0.399595991954321 2848 2242070
SGTC_1117 retinoic acid 1.10837 µM -0.254628071493988 0.443869341204827 no 1893 0.39950518786944 3011 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2015 5119600 184 µM -0.255247447919325 0.443607775748645 no 1894 0.399265993130481 3045 2828786
SGTC_58 0957-0393 9 µM -0.255877454257432 0.443341746435465 no 1895 0.399022732055812 2919 6997992
SGTC_413 propylparaben 100 µM -0.256367913849832 0.443134660430908 no 1896 0.398833380581978 2851 7175 A pharmaceutical preservative.
SGTC_116 0155-0182 31.788 µM -0.257782183287735 0.442537602767722 no 1897 0.398287507784411 2886 771486
SGTC_48 0382-0018 55 µM -0.258473077785424 0.442245977376935 no 1898 0.398020911987287 3132 762596
SGTC_3292 9120825 59.784 µM -0.258949872505835 0.44204474137883 no 1899 0.397836958730341 2990 24824900
SGTC_1270 0831-1170 17.3 µM -0.259382184736331 0.441862292588508 no 1900 0.397670186994313 2847 6764716
SGTC_1495 4469-0029 237 µM -0.259899491682842 0.44164398967864 no 1901 0.39747065169107 2849 793680
SGTC_863 0466-0191 129 µM -0.260088174702772 0.441564370079046 no 1902 0.397397879671656 2980 765160 YPR165W RHO1
SGTC_1148 3909-7663 27.7 µM -0.260652334520862 0.441326322591179 no 1903 0.397180313575126 2993 4084526
SGTC_1684 st024538 14.6195 µM -0.261175920038424 0.441105414408387 no 1904 0.396978423424734 2867 6732859
SGTC_1057 3448-5381 134 µM -0.263268935537502 0.440222525073271 no 1905 0.396171650599289 3012 5497911
SGTC_2780 5215298 71.43 µM -0.264118094466657 0.439864411842907 no 1906 0.395844460721496 3016 2834131
SGTC_1435 4092-0789 56.7 µM -0.264419287935523 0.439737402235294 no 1907 0.395728425322921 2975 2248285
SGTC_3159 9100096 49.47 µM -0.264457033205378 0.439721485952999 no 1908 0.395713884532065 2777 25236875
SGTC_1238 0333-0287 48.8 µM -0.267663389783646 0.438369799910787 no 1909 0.394479216269296 2882 7226
SGTC_1631 benzylvanillin 81.9 µM -0.268922295212995 0.437839285686979 no 1910 0.393994739832357 3018 75506
SGTC_2427 5545055 42.75 µM -0.26938763215069 0.43764321668658 no 1911 0.393815701308175 2905 5372858
SGTC_491 tetrandrine 80.3 µM -0.270209250277381 0.437297066567122 no 1912 0.393499638307697 2985 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_862 0452-0056 10.2 µM -0.270274874277334 0.437269421050161 no 1913 0.393474396855728 2941 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2956 9076196 2.52 µM -0.273918273385104 0.435735045384093 no 1914 0.392073714172526 3015 16423868
SGTC_2373 9071805 200 µM -0.274629141945502 0.435435783264595 no 1915 0.391800587425885 3027 10149009
SGTC_2711 st079103 59.1 µM -0.27477421998936 0.435374712709507 no 1916 0.391744852733848 2946 54693780
SGTC_181 1447-1644 8.07 µM -0.274915449285393 0.435315263764085 no 1917 0.391690598750961 2991 534600
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.277268408909509 0.434325026939434 no 1918 0.390787007496227 2978 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_578 3460-0051 92 µM -0.277415095620612 0.434263307802195 no 1919 0.390730695852039 2971 2876744
SGTC_1075 aripiprazole 15.2 µM -0.278484121836052 0.433813558377979 no 1920 0.390320376048445 2881 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1785 bathophenanthroline 24 µM -0.27850479384382 0.433804862311617 no 1921 0.390312442801611 2919 72812 An iron chelator.
SGTC_431 k089-0097 107 µM -0.27883976334904 0.433663955598592 no 1922 0.390183898726624 3010 5499420
SGTC_1240 0356-0016 42.1 µM -0.280070856346918 0.433146162309844 no 1923 0.389711571773339 2936 4305613
SGTC_2907 7721985 69.9 µM -0.282489744396354 0.432129121720587 no 1924 0.38878400464405 2965 3267881
SGTC_2179 6298986 200 µM -0.282690660986597 0.432044664884462 no 1925 0.388706987911666 3047 738374
SGTC_818 4072-2707 53.5 µM -0.282977817404236 0.431923961864736 no 1926 0.388596920728358 2856 882871
SGTC_1882 5615643 20 µM -0.284445116226941 0.43130729848714 no 1927 0.388034644218137 2921 2253075
SGTC_217 ketoconazole 989 nM -0.285265687475948 0.430962508944457 no 1928 0.38772029928886 2989 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2308 7584454 197.62 µM -0.285398688038107 0.430906629405604 no 1929 0.387669356277053 3076 893577
SGTC_3346 9158254 43.5805 µM -0.287341770227753 0.430090411164453 no 1930 0.386925321246962 2997 17639500
SGTC_596 1155-0152 116 µM -0.287365806415128 0.43008031629823 no 1931 0.38691612002894 2937 280313
SGTC_1078 idebenone 36.1 µM -0.28886319516599 0.429451524107512 no 1932 0.386343034806644 2977 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1465 k213-0056 144 µM -0.288894400305086 0.429438422162011 no 1933 0.386331094512024 2887 24048857 YMR208W ERG12
SGTC_3157 9099274 49.47 µM -0.289463319852394 0.429199566400848 no 1934 0.386113422743568 3037 17217662
SGTC_394 menadione 8.33 µM -0.289953880965997 0.428993629532615 no 1935 0.385925760121579 3066 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2436 5633522 8.09 µM -0.292682843522097 0.427848369208412 no 1936 0.384882292404784 3097 5724242
SGTC_1707 st032323 6.317 µM -0.292798009769011 0.427800050827052 no 1937 0.38483827479847 2945 3132057 YMR211W DML1
SGTC_2653 dihydrofissinolide 100 µM -0.294077461994651 0.427263325387812 no 1938 0.384349356269271 2991 6857746
SGTC_2697 mebhydrolin 72.4 µM -0.294542289618228 0.427068365215347 no 1939 0.384171776672316 3081 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1081 sertraline 6 µM -0.295297351420939 0.426751711656764 no 1940 0.383883369810269 3034 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1158 4092-0494 91.8 µM -0.295846088337903 0.426521615069296 no 1941 0.383673812081345 3068 1148199
SGTC_710 3448-4187 58 µM -0.295968696546368 0.426470206360505 no 1942 0.383626993748753 2967 3946412
SGTC_2399 5884133 200 µM -0.296118979093817 0.426407195711576 no 1943 0.383569610199671 2933 722445
SGTC_764 1951-2361 146 µM -0.296458302481427 0.42626493070094 no 1944 0.383440053116396 2937 5438930
SGTC_3160 9100216 49.47 µM -0.296560061836833 0.426222268856723 no 1945 0.383401202910213 2893 17191039
SGTC_1263 0774-1208 64.8 µM -0.298304572406585 0.425491030601507 no 1946 0.382735357398602 3102 906585
SGTC_1839 st053978 48 µM -0.298885667732492 0.425247512379236 no 1947 0.382513641517659 3020 3788398
SGTC_1902 st060212 70.5 µM -0.30057898915805 0.424538059190205 no 1948 0.381867777589915 2957 688944
SGTC_2071 5230951 39.92 µM -0.300634751291043 0.424514700597422 no 1949 0.381846514467286 3003 1799272
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.301242030503849 0.424260330310913 no 1950 0.381614970872847 3049 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2059 5238311 157 µM -0.30124559222729 0.424258838509207 no 1951 0.381613612982758 2916 703021
SGTC_161 4065-0411 162.148 µM -0.301625054229636 0.424099909856831 no 1952 0.381468953251951 3059 1906281 YLR208W SEC13
SGTC_398 bronopol 33.3 µM -0.301953664319894 0.423962289291947 no 1953 0.381343692827461 2911 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2728 chlorpromazine 9.18 µM -0.302266915465991 0.42383110962232 no 1954 0.381224298534527 2915 2726 A thorazine and dopamine antagonist.
SGTC_2488 5268135 45.7 µM -0.302353988246534 0.423794647795014 no 1955 0.381191113135569 3076 1270356 YLR208W SEC13
SGTC_1471 k673-0312 37 µM -0.302979969545817 0.423532536627133 no 1956 0.380952563286512 2975 24099884
SGTC_826 1683-5028 118 µM -0.303205627176068 0.423438057454334 no 1957 0.380866580442948 3019 722377
SGTC_2451 5856223 45.7 µM -0.303273490239447 0.423409645156202 no 1958 0.380840723574941 2976 2179896
SGTC_392 N-ethylmaleimide 8.33 µM -0.304461870181323 0.422912169588444 no 1959 0.380388018939002 2987 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2069 5228469 200 µM -0.304794118226399 0.42277310699212 no 1960 0.380261480747858 3055 2835210
SGTC_1279 0874-0590 65.2 µM -0.305137573320529 0.422629363795211 no 1961 0.380130687769988 2993 3523074
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.306326845712302 0.422131707944861 no 1962 0.379677900557724 3070 6708760
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.308424245473609 0.42125434589853 no 1963 0.37887976768928 3061 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2560 caryophyllene 100 µM -0.309878886888732 0.420646084986728 no 1964 0.378326529439172 2920 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2925 9010536 32.5 µM -0.311006026572879 0.420174899678691 no 1965 0.377898020067279 3012 2994177
SGTC_2824 7998404 51.95 µM -0.311729972650487 0.419872324218018 no 1966 0.377622873660949 2934 837851
SGTC_1632 st005650 90 µM -0.31311986720241 0.419291546461446 no 1967 0.377094797831283 3069 2759605
SGTC_2879 9041815 71.43 µM -0.31323743170599 0.419242429307129 no 1968 0.377050140960222 3065 4942971
SGTC_1167 k781-0610 148 µM -0.313423510010975 0.419164690414002 no 1969 0.376979462486489 2992 4525169
SGTC_940 3232-1287 54.8 µM -0.31357532083779 0.419101269959259 no 1970 0.37692180294677 2986 1585493 YIL048W NEO1
SGTC_3024 9090631 49.47 µM -0.314026508950237 0.418912794134442 no 1971 0.376750452594295 3090 25236383
SGTC_3325 9138760 55.175 µM -0.314342738274998 0.41878070603699 no 1972 0.376630370799264 2989 43844959
SGTC_851 0394-0702 453 µM -0.314734997022025 0.418616873388173 no 1973 0.376481434930491 3095 762646
SGTC_2979 9012552 45.46 µM -0.315743954743667 0.418195532234146 no 1974 0.376098430489938 3075 17100905
SGTC_847 0342-0274 5.54 µM -0.318670443242282 0.416973962053837 no 1975 0.37498821494404 3091 18097
SGTC_2279 7948423 32.93 µM -0.318987863161662 0.416841513086071 no 1976 0.374867858102137 3160 1247112
SGTC_475 α-linolenic acid 10 µM -0.319486032424955 0.416633662355503 no 1977 0.37467899068949 3195 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1874 staurosporine 7.6 µM -0.320377940317747 0.416261590647583 no 1978 0.374340923024699 3091 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1715 st032160 10.2275 µM -0.320777559502752 0.416094908298777 no 1979 0.374189483181711 3086 5289825
SGTC_1317 1273-0028 910 nM -0.321720462491522 0.415701680522857 no 1980 0.37383223727025 2982 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2518 prenyletin 46.28 µM -0.321887015182424 0.415632230233814 no 1981 0.373769145245947 3066 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1565 sinapyl alcohol 95.1 µM -0.322395965342904 0.415420021027055 no 1982 0.373576370192597 3065 5280507 A phenol propionate derived from cinnamic acid.
SGTC_177 1327-0068 8.361 µM -0.322761549541573 0.415267604164583 no 1983 0.373437917381592 3063 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1842 st055362 61.2 µM -0.32500711975087 0.414331676916197 no 1984 0.372587841594905 2978 676032
SGTC_1572 epiandrosterone 68.9 µM -0.325639248113847 0.414068300723452 no 1985 0.37234865682612 2936 441302 A steroid.
SGTC_530 4358-1714 28 µM -0.326247398298013 0.413814951505053 no 1986 0.372118591385486 3060 1564641
SGTC_194 1486-1323 56.904 µM -0.326974526715462 0.413512084246321 no 1987 0.371843575959973 3026 5178754
SGTC_1485 3909-9022 254 µM -0.326988030137051 0.413506460217949 no 1988 0.371838469296793 3034 714516
SGTC_1776 st049249 45.9 µM -0.327191945806985 0.413421533714951 no 1989 0.37176135612851 3021 1822314
SGTC_1341 1486-1360 280 µM -0.330035802838092 0.412237552125502 no 1990 0.370686454802803 2964 3976547
SGTC_1419 3993-2473 62.6 µM -0.3309843412508 0.411842824600871 no 1991 0.370328156722512 3023 704026
SGTC_1886 st057356 49.9 µM -0.331571624233318 0.41159847563733 no 1992 0.370106374551304 2979 24207747
SGTC_367 0335-0881 7.1 µM -0.333476375795135 0.410806208071089 no 1993 0.369387359642944 3147 23828853
SGTC_2998 9066762 71.4286 µM -0.33376306247186 0.410686994247081 no 1994 0.369279179231915 3185 4945196
SGTC_1800 st050079 29.0735 µM -0.333921521020637 0.410621105469102 no 1995 0.369219389785431 3087 3645560
SGTC_16 erodoxin 22.806 µM -0.334375608332969 0.41043230503113 no 1996 0.369048071469114 3100 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_158 k038-0087 26.446 µM -0.334906769467394 0.41021148517798 no 1997 0.368847707707303 2956 X158
SGTC_2193 5925765 200 µM -0.334909292381481 0.410210436393663 no 1998 0.36884675610265 3095 877370
SGTC_1745 st081495 74 µM -0.336169277710332 0.409686736433452 no 1999 0.368371609469247 3016 13842402 YBL026W LSM2
SGTC_218 alverine citrate 93.75 µM -0.336746536367364 0.409446858552633 no 2000 0.368153989574683 3131 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1427 4048-4900 550 nM -0.337246510216848 0.409239123502756 no 2001 0.367965539347503 3119 24132586
SGTC_2397 5161689 200 µM -0.338740196311595 0.408618661153477 no 2002 0.367402728350964 3199 2259942
SGTC_3288 9119690 36.221 µM -0.338842919373907 0.408575999412225 no 2003 0.367364033433555 3036 17595618 YKL019W RAM2
SGTC_193 1273-0060 1.558 µM -0.339201238902001 0.408427194818663 no 2004 0.36722906801296 3021 2847393 YHR072W ERG7
SGTC_2016 5121758 140 µM -0.339423064892955 0.408335080508791 no 2005 0.367145522767511 2951 2795203
SGTC_1889 st059080 5.18 µM -0.340358014203796 0.40794689402738 no 2006 0.366793466518923 3178 176925 Isolated from Daphnopsis sellowiana.
SGTC_651 3253-0966 34.4 µM -0.340586539658057 0.407852025077202 no 2007 0.366707432018757 3018 781462
SGTC_2898 9056270 58.44 µM -0.341836607437862 0.407333173741462 no 2008 0.366236929273877 3036 19154699
SGTC_1314 1222-0010 41.1 µM -0.342286638006777 0.407146424444119 no 2009 0.366067595138757 3064 3526027
SGTC_1481 3346-2004 36 µM -0.343310384896274 0.406721678624112 no 2010 0.365682484519659 3077 2770522
SGTC_555 4296-0685 37 µM -0.343571993159667 0.406613156663559 no 2011 0.365584095053599 3055 2908540 YHR072W ERG7
SGTC_366 0181-0206 4.31 µM -0.343972470075264 0.406447042243528 no 2012 0.365433494963569 3202 274874
SGTC_1009 4106-0057 9.87 µM -0.344393546260624 0.406272401578249 no 2013 0.365275170852326 3173 2928005
SGTC_1638 st008370 60.6 µM -0.345677535346793 0.405739984436229 no 2014 0.364792534426607 3013 24207134
SGTC_1506 4226-2149 212 µM -0.34615892069833 0.405540418726531 no 2015 0.364611642485222 3118 991114
SGTC_1771 st048882 4.1505 µM -0.346402858828509 0.405439299788202 no 2016 0.364519988462495 3001 4580403
SGTC_441 propafenone 146 µM -0.346906128824642 0.405230700740777 no 2017 0.364330921058534 2980 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2323 6148992 148.28 µM -0.349502374173153 0.40415501876018 no 2018 0.363356094366749 3033 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3168 9103419 49.47 µM -0.349689398926696 0.404077558130089 no 2019 0.363285905212336 3096 16649256
SGTC_528 3492-0019 172 µM -0.350489206419805 0.403746341814437 no 2020 0.362985794559756 3097 2869262
SGTC_2851 9015922 71.43 µM -0.350801557998104 0.403617009489506 no 2021 0.362868614142127 3198 2996893
SGTC_3027 9089541 49.47 µM -0.350919378911547 0.403568227287205 no 2022 0.362824416310881 3114 9943819
SGTC_1681 tripelennamine 100 µM -0.351103891865638 0.403491835135669 no 2023 0.362755204151945 3096 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3135 9127742 49.47 µM -0.351757294732446 0.403221342558008 no 2024 0.362510144022453 3071 3643468
SGTC_3031 9088762 49.47 µM -0.351768867399961 0.403216552177639 no 2025 0.362505804176281 2969 205253
SGTC_1082 camptothecin 424.86 nM -0.351958287655748 0.403138145779351 no 2026 0.362434772522964 2854 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_379 3970-0972 5.9 µM -0.352742603352526 0.402813536819215 no 2027 0.362140708461457 3070 2898042 YBL034C STU1
SGTC_303 1348-1668 34.2 µM -0.352849516564695 0.402769293254977 no 2028 0.362100629708577 3061 5380509
SGTC_187 1488-2104 32.728 µM -0.353127037806934 0.402654453308851 no 2029 0.361996601865944 3088 2852859
SGTC_235 0330-0087 5 mM -0.353678011873225 0.402426481851346 no 2030 0.361790101429719 3060 46494818 YHR062C RPP1
SGTC_3099 9120367 49.47 µM -0.353928109718271 0.402323012116823 no 2031 0.361696380139239 3006 24824940
SGTC_1125 tnp00248 1.32998 µM -0.354250143928209 0.402189791163844 no 2032 0.361575713742028 3189 24207736
SGTC_2701 st077767 14.721 µM -0.354715421748809 0.401997332444073 no 2033 0.361401398198036 3060 5721188
SGTC_1439 4092-1168 46 µM -0.354808031857859 0.401959027793219 no 2034 0.361366705409931 3096 2886240
SGTC_1792 st045773 43.6 µM -0.355169102362629 0.401809693701971 no 2035 0.361231455227848 3005 2919270
SGTC_3028 9087778 49.47 µM -0.355285557475609 0.401761532429674 no 2036 0.361187837043274 3039 17217395
SGTC_3301 9125354 19.7965 µM -0.36052879410046 0.399594691564475 no 2037 0.359225863887542 3020 41905162
SGTC_761 k216-0224 480 µM -0.361062760975467 0.399374194474357 no 2038 0.359026265264527 3219 1340404
SGTC_1515 3460-0031 42.1 µM -0.363466824300501 0.398381855431117 no 2039 0.358128095583856 3084 2876596
SGTC_3189 9110682 49.47 µM -0.364180703644598 0.398087309528326 no 2040 0.357861537666753 3156 17122418
SGTC_57 miconazole 162.5 nM -0.365202791036815 0.39766569841557 no 2041 0.357480017514961 3091 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2747 doxorubicin 7.63 µM -0.366501966292459 0.397129961086592 no 2042 0.356995272821172 3068 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1810 st050138 53 µM -0.367162088791869 0.396857822469028 no 2043 0.356749058099921 3179 3444541
SGTC_3048 9093155 49.47 µM -0.367381317239352 0.396767455609006 no 2044 0.356667302726425 3171 25236002
SGTC_285 1486-1325 46 µM -0.367390534600883 0.396763656296405 no 2045 0.356663865502709 3166 22310230
SGTC_1141 3253-0389 52.6 µM -0.368533400441329 0.396292653438916 no 2046 0.356237772475169 3145 5402031
SGTC_1021 4476-0760 85.3 µM -0.369661841118406 0.395827744006189 no 2047 0.355817233601656 3057 746768
SGTC_517 1365-0151 113 µM -0.370872027690564 0.395329320510674 no 2048 0.355366425194525 3225 768657
SGTC_311 1315-0136 58 µM -0.371126728980433 0.39522444184573 no 2049 0.355271571785084 3235 6759207
SGTC_574 1315-0397 40 µM -0.371337563063217 0.395137632175771 no 2050 0.355193061762041 3054 6794277
SGTC_2301 7769476 200 µM -0.371408273997894 0.395108518537451 no 2051 0.355166731925423 3120 977820
SGTC_459 nigericin 15.3 µM -0.372866396707583 0.394508300037833 no 2052 0.354623941458871 3203 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3334 9142812 21.919 µM -0.373257919063363 0.394347177195502 no 2053 0.354478246313811 3155 45283678
SGTC_705 1124-0212 310 µM -0.373451805507828 0.394267393972145 no 2054 0.354406104256836 3227 9554485
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.373728830819151 0.39415340725255 no 2055 0.354303036616007 3029 5355888
SGTC_681 1642-0006 26.6 µM -0.37715884183503 0.392742825483731 no 2056 0.353027782479667 3174 4446530
SGTC_3058 9093861 49.47 µM -0.377490872722025 0.392606353203183 no 2057 0.352904423031482 3223 17217477
SGTC_377 3970-0964 33.1 µM -0.377719400592201 0.392512430697427 no 2058 0.352819527045032 3065 16481235
SGTC_911 3456-4043 236 µM -0.380872320366592 0.391217255672508 no 2059 0.351648996183962 3152 914281
SGTC_2304 7443016 91.4 µM -0.381063056419862 0.39113894251066 no 2060 0.3515782298182 3031 939854
SGTC_830 4076-0286 57.8 µM -0.381083017270047 0.391130747161033 no 2061 0.351570824295731 3082 6866659
SGTC_166 k072-0058 166.424 µM -0.381983273346524 0.390761178276776 no 2062 0.351236885770537 3214 5846229
SGTC_112 phenothiazine 287.218 µM -0.382162642800948 0.390687556148175 no 2063 0.351170364665723 3223 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_713 1488-1073 324 µM -0.382340615201872 0.390614511312469 no 2064 0.351104366179945 3106 3312542
SGTC_2217 6934799 96.0675 µM -0.382470955878089 0.390561018313243 no 2065 0.351056034077693 3162 675606
SGTC_1431 4049-0260 9.09 µM -0.384267922477904 0.38982373842217 no 2066 0.350389940219685 3080 3854841
SGTC_1857 st056007 79.3 µM -0.387281909747846 0.388588016323188 no 2067 0.349273758280938 3163 619834
SGTC_274 sirtinol 40.1 µM -0.387947819655229 0.388315147583297 no 2068 0.349027324530461 3123 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2616 abietic acid 100 µM -0.38824488908908 0.388193435730537 no 2069 0.348917408362145 3247 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_542 3381-0244 89.3 µM -0.388756414175167 0.387983885325237 no 2070 0.348728172968765 3244 1112843
SGTC_2491 paeonol 100 µM -0.388785410754445 0.387972007617275 no 2071 0.348717446998561 3033 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3089 9117425 49.47 µM -0.388830360228302 0.387953595420742 no 2072 0.348700820217096 3146 9401657
SGTC_2790 5423970 71.43 µM -0.389104255927798 0.387841407751829 no 2073 0.34859951265531 3259 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1297 1068-0111 14.1 µM -0.389598168427162 0.387639124877074 no 2074 0.348416853358841 3071 767057
SGTC_3046 9092212 49.47 µM -0.38985232244196 0.387535047459801 no 2075 0.348322875517715 3153 25236637
SGTC_1335 1486-0900 202 µM -0.390226533644162 0.387381820698677 no 2076 0.348184521404828 3045 X1335
SGTC_3094 9117742 49.47 µM -0.390542032486159 0.387252648281063 no 2077 0.348067890238528 3039 17149698
SGTC_479 n-linoleoylglycine 10 µM -0.390555503846269 0.387247133076942 no 2078 0.348062910570364 3102 6433346 An anti-infammatory.
SGTC_2051 5263410 176 µM -0.390935948501025 0.38709138760932 no 2079 0.347922290591965 3205 227584
SGTC_2108 5365811 200 µM -0.390998319734873 0.387065855965339 no 2080 0.347899238927227 3196 780283
SGTC_2684 capsaicin 100 µM -0.391264977598352 0.386956705168306 no 2081 0.347800691699016 3200 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2807 7945238 51.95 µM -0.393406099999938 0.386080606421238 no 2082 0.347009782494946 3163 17148797
SGTC_2147 5545932 89.7195 µM -0.394629543021033 0.385580261639808 no 2083 0.346558153649708 3130 797404
SGTC_2257 7960413 200 µM -0.395313847249689 0.385300488444351 no 2084 0.346305640650898 3073 2974689 YIL048W NEO1
SGTC_1476 4112-3294 3.34 µM -0.395317934146923 0.385298817722969 no 2085 0.346304132762592 3224 704369
SGTC_1726 st035556 14.5795 µM -0.395870945736051 0.38507276652908 no 2086 0.346100117882313 3278 5919439
SGTC_3191 9110352 49.47 µM -0.396203522989691 0.384936839741195 no 2087 0.345977446279098 3151 17122424
SGTC_1037 k284-1091 78.7 µM -0.396611446998506 0.38477013748474 no 2088 0.345827004987652 3085 3334711
SGTC_81 0411-0046 9.971 µM -0.397673381740533 0.384336267126843 no 2089 0.345435480473163 3152 12925265
SGTC_1418 3966-3099 2.4 µM -0.398752103377602 0.383895686535487 no 2090 0.345037936051096 3192 740335
SGTC_1456 k015-0012 13 µM -0.398952878025353 0.383813701003099 no 2091 0.344963962846 3289 2989616
SGTC_2145 5634607 200 µM -0.399330436450265 0.383659540602451 no 2092 0.34482487165683 3099 308662
SGTC_2960 9079389 5.97 µM -0.400343846384712 0.38324584758088 no 2093 0.344451638743571 3260 16457355
SGTC_2000 st075254 36.4 µM -0.400831117500684 0.383046981690032 no 2094 0.344272233537665 3141 17234175
SGTC_19 0279-0214 38.434 µM -0.401208489459959 0.382892989198618 no 2095 0.344133315465448 3128 3566274 YBR002C RER2
SGTC_1091 telmisartan 47.6 µM -0.40142851833448 0.382803211537826 no 2096 0.344052328195606 3230 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_674 0498-0004 451 µM -0.402265350721534 0.382461819112016 no 2097 0.343744375939303 3184 4231473
SGTC_463 ikarugamyin 104 µM -0.402414450233381 0.382401002359069 no 2098 0.343689518559875 3180 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_18 0111-0177 500 nM -0.402732694979065 0.382271202033963 no 2099 0.343572439497912 3140 721752
SGTC_1102 cgs 12066b 26.1 µM -0.402866883778636 0.382216475322802 no 2100 0.343523077276083 3153 6438352 A 5-HT1B full agonist.
SGTC_1436 4092-1007 8.32 µM -0.40354171944834 0.381941290302966 no 2101 0.343274875058987 3119 2881121
SGTC_1256 0570-0116 285 µM -0.407082760262784 0.38049830240644 no 2102 0.341973602439627 3138 410638
SGTC_912 3474-0017 2.18 µM -0.407241659945913 0.38043358896393 no 2103 0.341915253335065 3265 3360550
SGTC_200 k038-0079 37.545 µM -0.407444752245106 0.38035088251997 no 2104 0.341840681881565 3100 3436683
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.407914767170004 0.380159496623845 no 2105 0.341668125416747 3211 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2598 perillyl alcohol 100 µM -0.408763190400468 0.379814100539543 no 2106 0.341356727775462 3258 10819 An apoptosis inducer.
SGTC_337 1315-0038 354 µM -0.410781301069222 0.378992906230617 no 2107 0.340616452790018 3148 1626437
SGTC_2266 7929956 200 µM -0.411966051479962 0.37851107060818 no 2108 0.340182153165497 3146 2967153
SGTC_666 0272-0154 136 µM -0.415188930746273 0.377201289473051 no 2109 0.339001800716402 3164 6870312
SGTC_585 0kpi-0023 191 µM -0.416828173233127 0.376535640351268 no 2110 0.338402046859593 3243 64601
SGTC_449 xestospongin c 11.1929 µM -0.418143448336032 0.376001810275878 no 2111 0.337921119935964 3231 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3243 9134147 49.47 µM -0.418495666157627 0.375858896019047 no 2112 0.337792377262588 3230 24282180
SGTC_981 1488-1094 54.9 µM -0.418921845949396 0.375685994065679 no 2113 0.337636625378729 3109 3449522
SGTC_280 3448-3607 3.04 µM -0.420996909733661 0.374844493965152 no 2114 0.336878669216042 3245 626179
SGTC_3217 9129673 49.47 µM -0.422741115194099 0.374137627220592 no 2115 0.336242077158645 3307 17248312
SGTC_772 k072-0172 35.3 µM -0.423051403131225 0.374011922391902 no 2116 0.336128878814687 3154 5861980
SGTC_310 1273-0058 1.06 µM -0.425438703978025 0.373045220502548 no 2117 0.335258448248177 3255 2734232
SGTC_1097 itavastatin 7.23 µM -0.426949853204673 0.372433715569441 no 2118 0.334707926575225 3174 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2702 st077768 96.8 µM -0.427610626895254 0.372166426372032 no 2119 0.334467313858329 3225 6484119
SGTC_927 2425-1185 123 µM -0.427794869667355 0.372091909404417 no 2120 0.334400236205432 3104 730375
SGTC_2923 7992654 58.14 µM -0.42782187114956 0.372080989060474 no 2121 0.334390406163234 3167 2985126
SGTC_509 pifithrin 175 µM -0.42798799846901 0.372013803625342 no 2122 0.334329929072471 3267 4817 A p53 inhibitor.
SGTC_1526 st051518 75 µM -0.428147115436379 0.371949456979646 no 2123 0.334272008065998 3155 673993
SGTC_1716 st033144 30.6155 µM -0.430458455011469 0.371015159104415 no 2124 0.33343109071321 3319 674617
SGTC_1878 temozolomide 1 mM -0.430766098753865 0.370890859438972 no 2125 0.333319225976884 3261 5394 DNA alkylating agent.
SGTC_2405 ticlatone 3.52 µM -0.430895664407178 0.37083851406311 no 2126 0.333272118036614 2957 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3108 9121785 49.47 µM -0.431393889035118 0.370637250313471 no 2127 0.333090996263521 3233 17140271
SGTC_618 k072-0232 33.2 µM -0.431488059483011 0.370599213019564 no 2128 0.333056766442456 3231 5872756 YGL099W LSG1
SGTC_43 0570-0105 72.5 µM -0.432002694562627 0.370391364153955 no 2129 0.332869727379331 3157 1114046 YDL195W SEC31
SGTC_537 1334-0398 209 µM -0.433585338657664 0.369752409163532 no 2130 0.332294791651559 3291 5846986
SGTC_2473 5854593 8.94 µM -0.434502623738148 0.369382241504736 no 2131 0.331961744972564 3094 2872951
SGTC_371 0195-0006 7.36 µM -0.434634006106279 0.369329232445393 no 2132 0.331914053692734 3144 3928593
SGTC_3222 9128301 49.47 µM -0.434734999396286 0.369288486205972 no 2133 0.331877395379252 3144 4911358
SGTC_947 3447-0010 211 µM -0.43515895184491 0.369117456530817 no 2134 0.331723527651229 3238 748350
SGTC_372 0155-0182 15.9 µM -0.435282274417435 0.369067710956648 no 2135 0.331678774742659 3145 771486
SGTC_1319 1306-0155 43.7 µM -0.435520907975186 0.36897145773171 no 2136 0.331592183097367 3184 3122360
SGTC_2180 6301957 200 µM -0.436492340340019 0.368579713805985 no 2137 0.331239777705673 3277 845462
SGTC_220 paclitaxel 373.376 µM -0.437325382804239 0.368243886308037 no 2138 0.330937694835263 3250 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3153 9100258 49.47 µM -0.437776029914598 0.36806225719996 no 2139 0.330774324319762 3161 25236848
SGTC_1330 1469-0054 61.8 µM -0.437780143518347 0.368060599386162 no 2140 0.330772833186948 3295 7102664
SGTC_502 l-744,832 89.3 µM -0.437807302622485 0.368049654120971 no 2141 0.330762988399595 3276 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2951 9072950 58.06 µM -0.439320854598122 0.367439854086512 no 2142 0.330214532632313 3266 16488155
SGTC_2601 securinine 100 µM -0.439433819188569 0.36739435478428 no 2143 0.330173613012298 3156 442872 A GABA receptor antagonist.
SGTC_2025 5147754 141 µM -0.439570946080165 0.367339126015061 no 2144 0.33012394371373 3207 315777 YLR208W SEC13
SGTC_721 1187-1332 279 µM -0.439743932692863 0.367269458418926 no 2145 0.330061289787914 3137 25730
SGTC_349 k015-0014 24 µM -0.439844910919173 0.367228793070165 no 2146 0.330024718742726 3111 2196908
SGTC_2729 fluphenazine 10.66 µM -0.441310545007607 0.366638729542898 no 2147 0.329494096542778 3160 3372 An atypical antipsychotic.
SGTC_2512 diallyl trisulfide 49.23 µM -0.442083349477879 0.366327725623632 no 2148 0.329214446376026 3263 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3047 9092122 49.47 µM -0.442678718225389 0.366088187976489 no 2149 0.328999068957822 3228 17173831
SGTC_2587 piperic acid 92.2 µM -0.443206056318079 0.365876065012033 no 2150 0.328808349343204 3196 5370536
SGTC_2914 7968218 45.32 µM -0.44351014092139 0.365753764910474 no 2151 0.328698392910067 3245 2977111
SGTC_2528 xanthyletin 44.79 µM -0.44450424317646 0.365354041159418 no 2152 0.328339030882351 3153 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2202 7226349 200 µM -0.444529732022713 0.365343794137257 no 2153 0.328329818902955 3156 844334
SGTC_1808 st050063 61.5 µM -0.445257330374031 0.365051325718756 no 2154 0.328066900033672 3311 4011993
SGTC_2398 5228213 48.84 µM -0.445697540267186 0.364874415240513 no 2155 0.327907870802257 3363 80771 YMR134W ERG29
SGTC_2159 5658611 73.75 µM -0.446776576778327 0.364440896411214 no 2156 0.327518192522739 3300 793844
SGTC_1859 st055998 20 µM -0.446862871450744 0.364406233732477 no 2157 0.327487036567808 3349 676301
SGTC_3337 9144342 33.5465 µM -0.447023309376047 0.36434179228125 no 2158 0.327429115017596 3280 17682949
SGTC_2335 9018011 154.17 µM -0.447766689975074 0.364043256312056 no 2159 0.327160792826128 3250 6458208
SGTC_1848 st056003 16.4 µM -0.448194466741999 0.363871501810476 no 2160 0.327006427869294 3303 146492
SGTC_2608 thymoquinone 42.66 µM -0.450478173099678 0.362955045787158 no 2161 0.326182844545721 3278 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1346 1488-2224 62.4 µM -0.450679098948429 0.362874451295403 no 2162 0.326110424231722 3310 3722427
SGTC_2239 6685329 187.64 µM -0.451298569650828 0.36262601017637 no 2163 0.325887187809913 3303 805680
SGTC_2440 5628896 157.78 µM -0.451800396883249 0.362424792816886 no 2164 0.325706391887902 3182 5522048
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.452477820715432 0.362153226874259 no 2165 0.325462397875332 3240 688788
SGTC_2885 9057732 51.95 µM -0.452542205413066 0.362127419918213 no 2166 0.32543921173267 3338 6471414
SGTC_33 0986-0033 35.816 µM -0.453145570778168 0.361885606845069 no 2167 0.325221961336707 3260 2848082
SGTC_1980 st071811 45.7 µM -0.454210684986885 0.361458871508714 no 2168 0.324838596612711 3349 4974850
SGTC_2650 prasterone 100 µM -0.454417680342547 0.361375959316884 no 2169 0.324764114638911 3258 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2314 7727897 200 µM -0.454490128780673 0.361346941562086 no 2170 0.324738047580131 3179 900724
SGTC_2626 ethyl orsellinate 100 µM -0.457111861488262 0.360297397521273 no 2171 0.323795322518253 3170 75653 A natural product.
SGTC_1989 st071868 50.2 µM -0.457285614763142 0.3602278768972 no 2172 0.323732883994344 3314 16414057
SGTC_3280 9140961 49.47 µM -0.458315379116591 0.359815951621061 no 2173 0.323362938361581 3169 4901226
SGTC_1818 st052136 56.3 µM -0.458470373149961 0.359753965149931 no 2174 0.323307271441652 3304 674169
SGTC_3310 9130229 44.1445 µM -0.458570791108517 0.359713807154468 no 2175 0.32327120791669 3310 7761258
SGTC_3275 9138069 49.47 µM -0.459184264826977 0.359468507447146 no 2176 0.323050924585652 3289 17617007
SGTC_2219 9098279 200 µM -0.459730374683437 0.359250192133798 no 2177 0.322854882158578 3297 902349
SGTC_2519 cryptotanshinone 88.04 µM -0.459955525592325 0.359160198174046 no 2178 0.322774071846729 3349 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1318 1280-3875 124 µM -0.46051265526551 0.358937544219836 no 2179 0.322574144953299 3261 373245
SGTC_1606 st000094 49.2 µM -0.460634216351424 0.358888969334408 no 2180 0.322530529373447 3337 1242210
SGTC_146 3448-8650 53.125 µM -0.461859910711971 0.358399318806341 no 2181 0.322090892201274 3225 2891488 YIL048W NEO1
SGTC_258 haloperidol 50.781 µM -0.462344993404505 0.358205598191357 no 2182 0.321916969405646 3238 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2247 cerulenin 830 nM -0.46254969830975 0.358123859035594 no 2183 0.321843585683122 3396 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3111 9122088 49.47 µM -0.462624646803391 0.358093933549782 no 2184 0.321816719478939 3203 16876704
SGTC_3242 9133940 49.47 µM -0.463349136384482 0.357804703825605 no 2185 0.321557065368839 3333 17248444
SGTC_1269 0831-0796 3.05 µM -0.463683486477333 0.357671252560954 no 2186 0.321437265043201 3326 927758
SGTC_2262 9014885 67.46 µM -0.465783054198899 0.356833637064207 no 2187 0.320685397948801 3221 6457424
SGTC_1981 st071826 47 µM -0.466459774788572 0.35656380845147 no 2188 0.320443216959887 3280 11838600
SGTC_1397 3532-0190 20.1 µM -0.467620807236134 0.356101037571867 no 2189 0.320027891258343 3141 5322280
SGTC_2471 5466956 24.79 µM -0.468543543391163 0.35573339925565 no 2190 0.31969796990085 3191 724419
SGTC_1474 0330-0125 5.35 µM -0.46968476017682 0.355278899037962 no 2191 0.319290128771886 3333 X1474
SGTC_1759 st043059 70 µM -0.470124768584966 0.355103716518933 no 2192 0.319132939591138 3195 669426
SGTC_2945 9067681 61.76 µM -0.471375214061439 0.354606038334559 no 2193 0.318686406376292 3342 16456930
SGTC_1766 st045414 44.774 µM -0.472039118412998 0.354341904703835 no 2194 0.318449433493161 3254 253960
SGTC_2385 9074692 200 µM -0.47294013875453 0.353983546789721 no 2195 0.318127943618241 3256 17046906
SGTC_2347 9049783 174.81 µM -0.473238561057797 0.353864885401717 no 2196 0.318021494798289 3355 6467988 YPL169C MEX67
SGTC_363 0455-0021 3.06 µM -0.474244703223859 0.353464918671721 no 2197 0.317662709366811 3243 4597466
SGTC_1558 st069300 45.6 µM -0.476400462414319 0.352608495404022 no 2198 0.316894552649682 3319 24208000
SGTC_1561 5-methoxyflavone 52.9 µM -0.476580849916152 0.352536866246726 no 2199 0.316830311297524 3302 94525
SGTC_2827 7993847 71.43 µM -0.476797096956111 0.352451004698732 no 2200 0.316753306576324 3307 2985692
SGTC_2744 captopril 92.04 µM -0.477308208056852 0.352248096365251 no 2201 0.31657133348494 3284 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_823 0417-1665 178 µM -0.477312836272281 0.352246259180872 no 2202 0.31656968588416 3286 3429856
SGTC_587 k089-0003 57 µM -0.477515943429356 0.352165638565308 no 2203 0.316497385248379 3318 9659696
SGTC_1258 0671-0043 57.1 µM -0.478082295691374 0.351940867861509 no 2204 0.316295816256786 3280 4298767
SGTC_2694 st077685 81.9 µM -0.478138965703818 0.351918379831114 no 2205 0.316275649979483 3172 2838096
SGTC_3175 9106517 49.47 µM -0.478859814501795 0.351632374831867 no 2206 0.316019180409845 3325 41468073
SGTC_2146 5545642 200 µM -0.47913226185611 0.35152430008442 no 2207 0.315922269872028 3336 825326
SGTC_1219 1469-0211 33.1 µM -0.480732178409716 0.350889885658414 no 2208 0.315353429035769 3327 6822282
SGTC_144 4161-2749 112.381 µM -0.481035674185792 0.350769587398994 no 2209 0.315245572229276 3266 797501 YMR168C CEP3
SGTC_168 3970-0862 530.542 µM -0.481165870161635 0.350717985501742 no 2210 0.315199307804076 3305 3135186
SGTC_1349 flufenamic acid 69 µM -0.481508598091444 0.350582161818875 no 2211 0.315077535173584 3245 3371 A non-steroidal anti-inflammatory.
SGTC_980 1473-0395 201 µM -0.482542924963881 0.35017237211284 no 2212 0.314710156492551 3219 768876
SGTC_1153 4055-0057 267 µM -0.482547773970405 0.35017045139648 no 2213 0.314708434623595 3244 882706
SGTC_2363 9053361 176 µM -0.48286262073458 0.350045747183183 no 2214 0.314596642023766 3417 6469797 YMR079W SEC14
SGTC_339 3091-4833 71.4 µM -0.483366717349914 0.349846118739577 no 2215 0.314417687894172 3315 3240077
SGTC_1126 isoteolin 1.0172 µM -0.483445323244212 0.349814993580046 no 2216 0.31438978675652 3231 133323
SGTC_2021 4019055 173 µM -0.486704096794289 0.348525524733607 no 2217 0.313234020783539 3398 44827708 YER133W GLC7
SGTC_1643 st009866 20.2 µM -0.486822029658333 0.348478892399841 no 2218 0.313192228662066 3329 3156273 YOR207C RET1
SGTC_924 2046-0044 21.3 µM -0.487129334483532 0.34835739045499 no 2219 0.313083339666146 3320 3623589
SGTC_2918 7977171 22.06 µM -0.488370534036373 0.347866804379675 no 2220 0.312643704598528 3291 2236483
SGTC_1433 4060-0023 7.6 µM -0.488896105221504 0.347659148214442 no 2221 0.312457626617188 3360 3840627
SGTC_3002 9075603 71.4286 µM -0.489951997812676 0.347242097226527 no 2222 0.31208393338481 3358 20105405
SGTC_1170 0310-0127 64.8 µM -0.491836375608741 0.346498275152059 no 2223 0.311417509609833 3299 774975
SGTC_588 3970-1144 52.9 µM -0.492220469714246 0.346346733831773 no 2224 0.311281747648652 3336 1888707
SGTC_277 nystatin 15.5 µM -0.492243202649199 0.34633776550103 no 2225 0.311273713266284 3208 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_358 0075-0058 9.45 µM -0.493229922962135 0.345948579268451 no 2226 0.310925068548069 3472 1069125
SGTC_2490 carminic acid 95.39 µM -0.494252115404694 0.345545573534207 no 2227 0.310564069114288 3356 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2571 chrysanthemic acid 100 µM -0.495179726575717 0.345180008496123 no 2228 0.310236629987068 3281 2743 An insecticide.
SGTC_97 0535-0701 19.132 µM -0.496967303832203 0.344475944416493 no 2229 0.309606054171937 3331 2832013 YGL099W LSG1
SGTC_3256 9138902 49.47 µM -0.498916842635561 0.343708703254558 no 2230 0.308918984084872 3312 17228773
SGTC_2404 5161160 200 µM -0.499019784417362 0.343668208361891 no 2231 0.308882723172001 3319 2831543
SGTC_634 1611-4317 11.2 µM -0.502223950700144 0.34240866311855 no 2232 0.307754998604577 3408 2843522
SGTC_716 1683-5115 658 µM -0.502228075378046 0.342407042849143 no 2233 0.307753548067457 3395 723597
SGTC_3143 9086658 49.47 µM -0.505044099583731 0.341301521400116 no 2234 0.306763931186901 3342 25236626
SGTC_2926 9010726 65.15 µM -0.507272269612789 0.340427744704625 no 2235 0.305981896440884 3382 2994293
SGTC_1128 3448-9350 235 µM -0.509363894254303 0.339608292901745 no 2236 0.30524858970643 3314 619386
SGTC_1829 berberine 14.4 µM -0.509605001193704 0.339513881217212 no 2237 0.305164109705515 3410 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1563 conessine 56.1 µM -0.510458573479447 0.339179723788243 no 2238 0.304865115120099 3391 441082 An anti-amoebic, histamine inhibitor.
SGTC_2135 5326629 150.42 µM -0.510546516610329 0.339145302894541 no 2239 0.304834317253913 3292 5020077
SGTC_3204 9114183 49.47 µM -0.512193135724843 0.338501065233997 no 2240 0.304257923356254 3268 17027248
SGTC_2752 diclazuril 33.15 µM -0.512325999014248 0.338449103208933 no 2241 0.30421143614563 3367 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1391 3442-0225 151 µM -0.51238546543912 0.338425847247918 no 2242 0.304190630609031 3299 5227075
SGTC_1086 cerivastatin 2.18 µM -0.513593985157732 0.337953356407911 no 2243 0.303767942866366 3366 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2858 9025781 8.96 µM -0.515033665641875 0.337390822532032 no 2244 0.303264747483541 3410 4894980 YPL153C RAD53
SGTC_32 0928-0142 34.1 µM -0.51513494319181 0.337351263487539 no 2245 0.303229363109435 3379 2244242
SGTC_1898 st060199 18.6 µM -0.516231405805155 0.336923100002764 no 2246 0.302846398978183 3351 688866
SGTC_167 3672-0051 66.205 µM -0.516882193899962 0.336669070169423 no 2247 0.302619199117846 3309 3237971
SGTC_2141 5621638 7.665 µM -0.519108562201336 0.335800589486991 no 2248 0.301842518918077 3410 2856238
SGTC_1618 st003135 44.5 µM -0.519706594278817 0.335567453140539 no 2249 0.301634045043096 3358 1270615
SGTC_2367 9070478 135.38 µM -0.519882443354845 0.335498912314493 no 2250 0.301572756409723 3373 572802
SGTC_2794 7785382 27.27 µM -0.519969134152995 0.335465124791507 no 2251 0.301542544149868 3417 2205081
SGTC_1459 k035-0031 35.7 µM -0.52037017642507 0.335308836882692 no 2252 0.301402796252653 3287 3877128 YMR208W ERG12
SGTC_1040 k898-0338 155 µM -0.521375790718667 0.334917070019861 no 2253 0.301052506395599 3455 20969351
SGTC_1084 voriconazole 435 nM -0.521517673744819 0.33486180972644 no 2254 0.301003098458686 3410 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2081 5214970 32.255 µM -0.521945469932505 0.334695214241894 no 2255 0.300854149091614 3383 2063512
SGTC_865 0488-0499 301 µM -0.522848898648517 0.334343501433144 no 2256 0.300539704072049 3449 9634651
SGTC_6 0844-0013 19.835 µM -0.523322247646302 0.334159280487959 no 2257 0.300375010739019 3453 1584900
SGTC_2929 9013348 24.6 µM -0.52419860755293 0.333818318679269 no 2258 0.300070204647263 3350 2995952
SGTC_2352 9027995 87.8 µM -0.524431424854955 0.333727760441059 no 2259 0.299989252161944 3334 2997347
SGTC_2618 avocadyne 43.43 µM -0.524766488877924 0.333597448606502 no 2260 0.299872765001338 3344 3015189
SGTC_2047 4141938 200 µM -0.52495370941149 0.333524644244191 no 2261 0.299807685498064 3319 3807862
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.5252922187545 0.333393024189754 no 2262 0.299690032912366 3414 61125 An anti-inflammatory.
SGTC_2975 9084847 53.72 µM -0.527952582521225 0.332359329954397 no 2263 0.298766123688645 3371 27211724
SGTC_2029 5175081 200 µM -0.528133174707235 0.332289206273587 no 2264 0.298703453354365 3375 1380876
SGTC_92 0063-0024 660.874 µM -0.528731239019377 0.332057020705048 no 2265 0.29849595167126 3407 3594437
SGTC_2449 5812982 45.77 µM -0.529941419801686 0.331587391396966 no 2266 0.298076273573987 3397 776185
SGTC_1286 0929-0070 131 µM -0.529947380050973 0.331585079084594 no 2267 0.298074207287063 3436 1420408
SGTC_1414 3917-0015 5.4 µM -0.530328027319109 0.33143741812386 no 2268 0.297942258798151 3409 6618702
SGTC_1210 3013-0140 750 nM -0.531233496051925 0.331086273356493 no 2269 0.297628491983915 3430 905973
SGTC_3235 9132602 49.47 µM -0.531556521339879 0.330961038650199 no 2270 0.29751659241677 3460 4912240
SGTC_533 1222-0222 6.71 µM -0.533587888613978 0.330173925274842 no 2271 0.296813344738299 3478 3982874
SGTC_3230 9131665 49.47 µM -0.533938394563966 0.330038187245969 no 2272 0.296692078602524 3357 15943720
SGTC_2063 5246145 200 µM -0.534679150394736 0.329751393446983 no 2273 0.29643587061237 3436 711240
SGTC_889 0919-1524 82.7 µM -0.534922111282907 0.329657349585695 no 2274 0.2963518589116 3380 3905452
SGTC_1976 st070609 63.5 µM -0.535273892139725 0.329521203422438 no 2275 0.296230238484279 3385 682556
SGTC_2292 7671323 168.05 µM -0.536526282146398 0.329036687173691 no 2276 0.295797438375621 3436 937504
SGTC_2062 5245942 200 µM -0.537552724022852 0.328639798237029 no 2277 0.295442938025563 3460 1376160
SGTC_2622 2-methoxyxanthone 59.94 µM -0.537645134373112 0.328604075882479 no 2278 0.295411032023314 3341 71034 A hepatoprotective.
SGTC_1213 1315-0166 115 µM -0.538293160369619 0.328353617502539 no 2279 0.295187336274084 3372 768401
SGTC_2844 9010103 25.97 µM -0.538486538924149 0.328278892721626 no 2280 0.295120597951404 3445 2480525
SGTC_2688 kanamycin b 96.69 µM -0.538656144007063 0.328213360071685 no 2281 0.295062069989931 3536 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2305 7443522 69.23 µM -0.538660683531891 0.328211606145637 no 2282 0.295060503547052 3392 5415886
SGTC_3092 9117248 49.47 µM -0.538788081382368 0.328162385267882 no 2283 0.29501654424041 3424 17141857
SGTC_2006 4011487 200 µM -0.53937967695577 0.32793385808858 no 2284 0.294812450583609 3474 45595294
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.541149549198394 0.327250559825413 no 2285 0.294202254049735 3338 88881 An O-methylated flavonoid and antioxidant.
SGTC_2529 gangaleoidin 93.61 µM -0.544131206570644 0.326100734196333 no 2286 0.293175593626857 3358 4565183
SGTC_3254 9136651 49.47 µM -0.54432453432839 0.326026237516547 no 2287 0.29310908335143 3376 16454030
SGTC_396 dithiazanine 1.25 µM -0.544859623511924 0.325820083121969 no 2288 0.292925033873475 3343 10578 An antihelmenthic.
SGTC_633 0437-0093 97.7 µM -0.54575297638624 0.325476018761653 no 2289 0.29261787545921 3414 2831118
SGTC_1917 st066507 28.5 µM -0.545944641469681 0.325402220567361 no 2290 0.292551995420268 3307 3156428
SGTC_257 daunorubicin 18.5 µM -0.546418577586186 0.325219766909937 no 2291 0.292389121432241 3434 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_87 0100-0052 35.5 µM -0.547872417915855 0.32466033593564 no 2292 0.291889754507945 3487 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_675 1309-0189 238 µM -0.548284510617894 0.324501836440821 no 2293 0.291748280672801 3371 4246530
SGTC_244 nsc-207895 1.295 µM -0.548387348283613 0.324462287872477 no 2294 0.291712980883162 3336 42640
SGTC_2546 rhodinyl acetate 100 µM -0.550493846413872 0.323652622136174 no 2295 0.290990348200805 3453 6708682
SGTC_3315 9136395 68.55 µM -0.550722997326789 0.323564594605378 no 2296 0.290911788610968 3511 16876844
SGTC_2121 5257820 149.641 µM -0.551050466417137 0.32343881562207 no 2297 0.290799539900557 3480 791256
SGTC_195 4234-0266 16.654 µM -0.551326245729854 0.323332906030826 no 2298 0.290705024941684 3374 2303354
SGTC_2458 5808907 16.39 µM -0.552903787213606 0.322727346339875 no 2299 0.290164646998126 3520 2731747
SGTC_3078 9116413 49.47 µM -0.55339116242128 0.322540355985963 no 2300 0.289997794584842 3359 17177322
SGTC_1385 3091-4834 14.1 µM -0.55343143934046 0.322524905021123 no 2301 0.289984007834476 3423 4072814
SGTC_101 0490-5701 117.494 µM -0.554140528431704 0.322252935661012 no 2302 0.289741337670711 3419 4661669
SGTC_976 1348-1067 47.6 µM -0.554938748391266 0.321946894195457 no 2303 0.289468278492651 3438 5310671 YGL099W LSG1
SGTC_1442 4112-3290 3 µM -0.555973952381778 0.321550171707323 no 2304 0.289114330731141 3423 704353
SGTC_2417 cerulenin 830 nM -0.556798549200013 0.321234305995911 no 2305 0.28883253761277 3507 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2060 5238662 140 µM -0.557238085730945 0.321065992250076 no 2306 0.28868238569132 3396 790130
SGTC_2760 etidronate 98.04 µM -0.558090382112389 0.320739723238486 no 2307 0.288391333943499 3385 3305 A chelator and antioxidant.
SGTC_2302 7771753 200 µM -0.560206144626787 0.319930383368411 no 2308 0.28766941815058 3427 2203047
SGTC_2008 4012253 172 µM -0.561523853383553 0.319426754434448 no 2309 0.287220236954682 3400 603940
SGTC_3172 9105863 49.47 µM -0.562837916911137 0.318924850219429 no 2310 0.286772629205797 3423 2348785
SGTC_1673 st016611 27.3 µM -0.563344867489379 0.318731310010317 no 2311 0.286600035722554 3487 5226799
SGTC_2337 9009472 200 µM -0.563555446600232 0.318650931050736 no 2312 0.286528357653359 3541 5742383
SGTC_1014 4130-3005 69.3 µM -0.563939436827956 0.318504382282604 no 2313 0.286397674858021 3388 743608
SGTC_921 1561-0023 372 µM -0.56403022913054 0.318469735810094 no 2314 0.286366779790953 3460 24050882
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.564488374426209 0.318294931130324 no 2315 0.286210904923405 3369 390807
SGTC_1540 guanosine 70.6 µM -0.564813175968193 0.318171028071668 no 2316 0.286100422044093 3438 6802 Guanosine is a purine nucleoside
SGTC_1961 st076550 68.7 µM -0.565104469106293 0.318059924871681 no 2317 0.286001354454894 3449 1579337
SGTC_2606 farnesol 9.78 µM -0.565472351396792 0.317919632912212 no 2318 0.285876262514036 3504 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2208 7283366 200 µM -0.56697372643694 0.317347354429066 no 2319 0.285366016087298 3475 898663
SGTC_548 1436-0017 110 µM -0.570266248951081 0.31609387423429 no 2320 0.284248564405772 3533 9677137
SGTC_297 0986-0032 24 µM -0.570931630688516 0.315840815946545 no 2321 0.284022994346121 3408 2847425
SGTC_3298 9116858 71.43 µM -0.571982768776518 0.315441222490262 no 2322 0.28366682421264 3484 2506942
SGTC_692 k241-0027 77.8 µM -0.573871295112851 0.314723835481602 no 2323 0.283027449451774 3546 3600480
SGTC_908 3448-7491 47.7 µM -0.576688714487204 0.313654892770856 no 2324 0.282074878748858 3499 1203031
SGTC_3071 9117417 49.47 µM -0.577469089676093 0.313359090574413 no 2325 0.281811306838407 3379 45595590 YGL055W OLE1
SGTC_1954 st077032 68.9 µM -0.578291387979503 0.313047527229393 no 2326 0.281533703878361 3434 698907
SGTC_1923 st058458 19.1 µM -0.578322412131888 0.313035774995924 no 2327 0.281523232893957 3542 3534982
SGTC_2865 9030313 51.95 µM -0.578842364735297 0.312838840457645 no 2328 0.281347771273993 3390 42562754
SGTC_2408 sulbentine 18.36 µM -0.583704670730315 0.310999809644456 no 2329 0.279709512141779 3353 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1157 4092-0394 27.6 µM -0.584491446387926 0.310702675342493 no 2330 0.279444859196722 3582 3659885
SGTC_2371 9071574 200 µM -0.585418274182499 0.310352807182526 no 2331 0.279133252086893 3490 45596039
SGTC_1264 0783-0040 158 µM -0.586226356494382 0.310047904208783 no 2332 0.278861706106796 3440 2855798
SGTC_186 3455-3465 67.277 µM -0.586350213644616 0.31000118236935 no 2333 0.278820096820232 3466 755278
SGTC_2492 derrusnin 100 µM -0.587433241681123 0.309592769406925 no 2334 0.278456386902999 3449 1715307 Part of coumarin class of compounds.
SGTC_3179 9107801 49.47 µM -0.587836902969012 0.309440607674263 no 2335 0.27832088575627 3470 4818259
SGTC_1415 3966-0071 78.1 µM -0.590848256358883 0.308306498231395 no 2336 0.277311049201318 3505 2893185
SGTC_2151 5563267 85.4165 µM -0.592052762520885 0.307853378675257 no 2337 0.276907628672871 3456 5310824
SGTC_2725 haloperidol 53.21 µM -0.592206953561045 0.307795395140485 no 2338 0.276856006827857 3475 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3202 9113761 49.47 µM -0.592335732637962 0.307746971451753 no 2339 0.276812896303643 3499 4798415
SGTC_1724 st037281 8.293 µM -0.592691080022656 0.307613370601332 no 2340 0.276693956055034 3492 574124 YDL195W SEC31
SGTC_916 4466-0038 42 nM -0.59277122031153 0.307583243580241 no 2341 0.276667135325777 3577 5722064 YGL116W CDC20
SGTC_149 3970-0822 46.1 µM -0.593093049026334 0.307462272055557 no 2342 0.276559441024671 3550 3114250 YBL034C STU1
SGTC_1971 st069429 63.5 µM -0.593927186205733 0.307148827462589 no 2343 0.276280407428575 3505 1246522 YGL099W LSG1
SGTC_1779 st039427 55 µM -0.594231990120319 0.30703432610686 no 2344 0.276178479615008 3554 1124498
SGTC_1174 0739-0097 51.1 µM -0.594667074447567 0.306870916760089 no 2345 0.276033017422648 3479 728447
SGTC_2359 9039622 200 µM -0.59519933439015 0.306671062289037 no 2346 0.275855117584622 3470 6463596
SGTC_1085 doxorubicin 7.67 µM -0.595699281448062 0.306483393087518 no 2347 0.275688069161439 3529 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1748 st037455 53.6035 µM -0.596130137871228 0.306321699704358 no 2348 0.275544146051111 3530 580690
SGTC_2457 5731572 11.68 µM -0.596393585403807 0.306222850721681 no 2349 0.275456162349187 3532 2865357
SGTC_22 0964-0034 14.468 µM -0.598105231432346 0.305580962363125 no 2350 0.274884859909216 3502 138402
SGTC_2957 9076800 11.52 µM -0.603583805987355 0.303530450546553 no 2351 0.273060191003113 3439 16459615
SGTC_3352 9151559 45.5865 µM -0.604892779428107 0.303041441068066 no 2352 0.27262512056692 3466 17159339
SGTC_3239 9133757 49.47 µM -0.604998202389374 0.303002072243915 no 2353 0.272590095555992 3510 17036923
SGTC_2867 9039098 71.43 µM -0.605472117261489 0.302825123217993 no 2354 0.272432672883029 3511 6463460
SGTC_2856 9022925 19.48 µM -0.606167541985477 0.302565551258401 no 2355 0.2722017519447 3502 4944862
SGTC_714 4296-0578 26.1 µM -0.607939721697673 0.301904524584343 no 2356 0.271613726704826 3516 1589775
SGTC_673 1082-0474 110 µM -0.60815431244602 0.301824525855786 no 2357 0.271542566510315 3529 3098046
SGTC_2499 avocadenofuran 51.48 µM -0.608894500730482 0.301548659223759 no 2358 0.271297184783166 3417 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2428 5615643 7.78 µM -0.608909691194047 0.301542998957695 no 2359 0.271292150110967 3525 2253075
SGTC_1046 2001-0062 216 µM -0.609235234004592 0.301421706782587 no 2360 0.271184264575631 3479 739778
SGTC_1507 4075-3230 155 µM -0.609513471831288 0.301318057115727 no 2361 0.271092072963339 3479 659771
SGTC_1935 st074532 41.6 µM -0.609762504789872 0.301225300512949 no 2362 0.271009571380567 3594 2829742
SGTC_1616 st002734 56.1 µM -0.610815027602138 0.300833412447134 no 2363 0.270661021800044 3486 4026101
SGTC_3021 9087658 49.47 µM -0.611469101858357 0.300589995509449 no 2364 0.270444533819103 3543 25237042
SGTC_3100 9120536 49.47 µM -0.612839887052538 0.300080139789782 no 2365 0.269991107019511 3462 16421196
SGTC_1850 st056238 17 µM -0.614499446832317 0.299463400051727 no 2366 0.269442669249474 3548 5393177
SGTC_3176 9106582 49.47 µM -0.614699281672473 0.299389174506967 no 2367 0.269376667153239 3464 17018027
SGTC_2972 9093619 59.92 µM -0.616823652722229 0.29860062622835 no 2368 0.268675524533083 3486 25236256
SGTC_3221 9128209 49.47 µM -0.617956679645011 0.298180442968616 no 2369 0.268301947530512 3545 16460723
SGTC_1339 1486-1321 22.7 µM -0.619253395922126 0.297699886239817 no 2370 0.267874720425217 3501 3469382
SGTC_1581 himbacine 57.9 µM -0.619778953940967 0.297505217685539 no 2371 0.267701663272 3523 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2067 5224629 34.075 µM -0.620044240096168 0.297406976831281 no 2372 0.267614330538629 3559 2835000
SGTC_774 k060-0086 136 µM -0.62030437576046 0.297310657699537 no 2373 0.267528707305651 3582 5911235
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.621088517629864 0.297020403681988 no 2374 0.267270691880271 3524 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2152 5568786 200 µM -0.624068974111633 0.295918357266631 no 2375 0.266291144270605 3538 5399883
SGTC_1900 st060200 72.8 µM -0.6246098770043 0.295718555786723 no 2376 0.266113567794585 3556 688945
SGTC_2401 5128683 200 µM -0.625193111729162 0.295503187043146 no 2377 0.26592216114118 3484 708373
SGTC_2143 5623677 140.463 µM -0.62564375776986 0.295336828205258 no 2378 0.265774315383633 3552 5375313
SGTC_2231 micatex 6.853 µM -0.6265391572321 0.295006413772362 no 2379 0.265480680784242 3565 20737 An antifungal of unknown mechanism.
SGTC_508 roscovitine 141 µM -0.62693950421121 0.294858735471523 no 2380 0.265349445472159 3575 160355 A CDKinase inhibitor.
SGTC_1363 1636-0063 10.4 µM -0.628771572795122 0.294183364927639 no 2381 0.264749306604447 3583 6072185
SGTC_1656 st012921 11 µM -0.629756901469778 0.293820430912885 no 2382 0.264426823750856 3511 6732821
SGTC_1614 st002383 48.6 µM -0.629941412323726 0.293752491582849 no 2383 0.264366458430337 3571 1947235
SGTC_1108 betulinic acid 729.144 nM -0.630135743438035 0.293680944164383 no 2384 0.264302887859536 3567 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2733 amorolfine 100 µM -0.630152085648148 0.293674927775823 no 2385 0.264297542268432 3564 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2090 5301565 104.445 µM -0.630928059388999 0.293389318547495 no 2386 0.264043782064863 3575 2056344
SGTC_111 0083-0039 52.457 µM -0.631656221067658 0.293121424398207 no 2387 0.263805770401081 3489 759313
SGTC_2555 cholic acid 100 µM -0.633784600348749 0.292339034666011 no 2388 0.263110702275819 3582 6708657 Influences liver metabolism.
SGTC_2023 5144124 124 µM -0.635583757471357 0.291678425021052 no 2389 0.262523879445627 3545 2830192
SGTC_643 k048-0106 28.4 µM -0.636510334728467 0.291338478559478 no 2390 0.262221923554361 3574 6763920
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.636557953066725 0.291321013144608 no 2391 0.262206410350038 3603 65057 A dermal irritant. YDR527W RBA50
SGTC_2767 sibutramine 71.45 µM -0.637643022674809 0.290923164701351 no 2392 0.261853041525337 3633 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1101 ebselen 5.29 µM -0.637735325770755 0.290889332840521 no 2393 0.261822992945247 3639 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_376 3970-0862 59.1 µM -0.637782308200876 0.290872113073043 no 2394 0.261807698847022 3568 3135186
SGTC_2472 5377652 49.4 µM -0.637851143381597 0.290846884804165 no 2395 0.261785291893389 3543 1610903
SGTC_1556 plumbagin 1.48 µM -0.638068519664007 0.290767222559595 no 2396 0.261714538891546 3534 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_314 1671-0008 2.74 µM -0.638164611083755 0.290732011030698 no 2397 0.261683265578409 3524 3913060
SGTC_990 3985-0011 41.3 µM -0.638331270771501 0.290670945349463 no 2398 0.261629030105048 3538 5399565 YGL099W LSG1
SGTC_1447 4239-0816 81.9 µM -0.638607370985024 0.290569792832031 no 2399 0.261539192484885 3508 1341554
SGTC_2655 perillic acid 100 µM -0.639654500094826 0.290186314696393 no 2400 0.261198621089836 3540 5702197 An apoptosis inducer.
SGTC_735 3076-0345 636 µM -0.640564037670874 0.289853417689654 no 2401 0.260902985429018 3617 2888990
SGTC_2223 6903751 107.57 µM -0.6420244323057 0.289319278255101 no 2402 0.260428659716668 3552 5598863
SGTC_1861 st057647 17.4 µM -0.643116761676696 0.2889200613381 no 2403 0.260074169522643 3624 688668
SGTC_3267 9137951 49.47 µM -0.643349494697038 0.288835037207715 no 2404 0.259998673573731 3554 16643986
SGTC_3138 9097216 49.47 µM -0.643549554738719 0.288761958880052 no 2405 0.259933785402198 3611 25237486
SGTC_2035 5154463 94.595 µM -0.644653771464964 0.288358765118926 no 2406 0.259575790238016 3591 2769623
SGTC_739 1486-1183 203 µM -0.644975899323646 0.288241193363591 no 2407 0.259471402008846 3588 4346692
SGTC_2 0422-0095 29 µM -0.645311335294681 0.288118788386265 no 2408 0.259362724222871 3488 6790840
SGTC_1193 1488-0126 41.5 µM -0.645894567683987 0.287906017670526 no 2409 0.259173818968562 3612 1384710
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.6466528277543 0.287629505582256 no 2410 0.258928329748991 3657 688801
SGTC_329 k048-0121 21.3 µM -0.647117760271251 0.287460022343564 no 2411 0.258777865811124 3588 6832902
SGTC_754 3474-0146 171 µM -0.648270265458764 0.287040099953116 no 2412 0.258405081147554 3532 24762078
SGTC_424 splitomicin 100 mM -0.648832279225669 0.286835432192421 no 2413 0.258223395418945 3560 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2120 5538279 151.968 µM -0.648982978287001 0.286780564089024 no 2414 0.258174689245453 3596 2058197
SGTC_96 0929-0093 37.281 µM -0.64940054586717 0.286628557677767 no 2415 0.258039755633999 3568 6991579
SGTC_1094 duloxetine 25.4 µM -0.649457984322977 0.286607651444953 no 2416 0.258021197720119 3607 60834 A selective serotonin reuptake inhibitor.
SGTC_1909 st060837 51.5 µM -0.649535067367658 0.286579596185274 no 2417 0.257996293881795 3546 678937
SGTC_62 0180-0423 3.232 µM -0.650363486826989 0.286278165664122 no 2418 0.257728728477527 3567 30102 YGL099W LSG1
SGTC_2095 5432005 200 µM -0.650402085856617 0.286264124607871 no 2419 0.257716265160159 3599 783734
SGTC_1199 1638-0010 4.46 µM -0.650783911737126 0.286125246542644 no 2420 0.257592993500786 3570 3111136
SGTC_650 1328-0195 38 µM -0.65112454187432 0.286001379251684 no 2421 0.257483047646781 3571 2780821
SGTC_2049 5262831 67.185 µM -0.651483599827435 0.285870838437193 no 2422 0.257367180207586 3616 763417
SGTC_3274 9138298 49.47 µM -0.652324834348317 0.285565106210416 no 2423 0.257095821286576 3582 17015756
SGTC_3066 9117245 49.47 µM -0.652741826535276 0.285413615280016 no 2424 0.256961366353305 3630 17176980
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.652946173178902 0.28533939126167 no 2425 0.256895490193888 3605 16486 A toxic proline analog.
SGTC_1891 st059073 26.2 µM -0.654314596759949 0.284842581295615 no 2426 0.256454571818915 3643 688754
SGTC_2525 harmine 47.85 µM -0.65545661539798 0.284428284458914 no 2427 0.256086905212086 3561 5280953 A monoamine oxidase inhibitor
SGTC_1946 st076057 65.1 µM -0.655545542807995 0.284396035823721 no 2428 0.256058287064334 3510 953009
SGTC_3343 9148379 18.9835 µM -0.656981004542219 0.283875721860554 no 2429 0.255596565276814 3639 1955036
SGTC_1370 2001-0092 44.6 µM -0.657889969004262 0.283546483937937 no 2430 0.255304418383414 3683 790957
SGTC_2589 lobaric acid 100 µM -0.658013666506453 0.283501693354751 no 2431 0.255264674726419 3583 73157 A novel microtubule depolymerizer.
SGTC_1171 0368-0077 21.4 µM -0.658202228035489 0.28343342218043 no 2432 0.255204096665382 3596 3239779
SGTC_125 0133-0007 11.75 µM -0.658242106706761 0.283418984594222 no 2433 0.255191286040669 3665 26541
SGTC_1460 k062-0059 9.15 µM -0.658416912886803 0.283355702310369 no 2434 0.255135135269686 3537 1373085
SGTC_1711 st032263 62.8 µM -0.659743413674798 0.282875711361486 no 2435 0.254709250906232 3608 3958979
SGTC_2330 7979373 200 µM -0.660861562573849 0.28247141555454 no 2436 0.254350549043419 3581 1863007
SGTC_444 curcumin 90.4 µM -0.662255978300353 0.281967617965276 no 2437 0.253903592134053 3592 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_724 3910-0327 137 µM -0.662333084878182 0.28193977225803 no 2438 0.253878888927977 3616 2885483
SGTC_1113 artemisinin 1.17947 µM -0.662756332964649 0.281786947128027 no 2439 0.253743312270674 3619 2240 An anti-malaria and mitochondrial poison.
SGTC_966 1300-0360 30.2 µM -0.66508622888784 0.280946390994732 no 2440 0.252997671096976 3615 70588
SGTC_2011 4012611 177 µM -0.665219636588474 0.280898298226402 no 2441 0.252955011293251 3633 2049887
SGTC_3053 9095903 49.47 µM -0.666732630813759 0.280353150504855 no 2442 0.252471465895041 3674 17174018
SGTC_2372 9071633 200 µM -0.667299001936352 0.280149212904583 no 2443 0.252290581890546 3651 21321366
SGTC_1941 st076221 61.8 µM -0.667512168201048 0.280072475114092 no 2444 0.252222519907533 3619 2828568
SGTC_504 lovastatin 124 µM -0.669520868467769 0.279349863238857 no 2445 0.25158163661809 3588 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_827 3253-0474 693 µM -0.669864619940514 0.279226292561446 no 2446 0.251472047704987 3625 5402065
SGTC_1152 3909-8331 15.9 µM -0.670412534616885 0.279029384887628 no 2447 0.25129742316587 3616 16001939
SGTC_1816 st051957 91.6 µM -0.67080730303795 0.278887556251573 no 2448 0.251171647241116 3632 674121
SGTC_3196 9111891 49.47 µM -0.671184096833604 0.278752218092732 no 2449 0.25105162921783 3638 18891510
SGTC_3209 9113616 49.47 µM -0.67127377084262 0.278720013367962 no 2450 0.251023070327055 3648 16649353
SGTC_2706 st078239 82.5 µM -0.672196998866723 0.278388558838795 no 2451 0.250729145664595 3644 15434492
SGTC_2678 equilin 100 µM -0.672383501163678 0.278321624678436 no 2452 0.250669791758647 3652 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1844 rapamycin 4 nM -0.672945894662695 0.278119833723636 no 2453 0.250490856448849 3618 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2333 9017922 200 µM -0.673742217569947 0.277834229280507 no 2454 0.250237608230145 3655 3163164
SGTC_759 3486-0358 89.3 µM -0.674909571104539 0.277415812174951 no 2455 0.249866609641113 3658 875103
SGTC_477 mead ethanolamide 10 µM -0.676221482036933 0.276945948983007 no 2456 0.249450017727681 3527 16061185
SGTC_2730 imipramine 71.33 µM -0.676642893461734 0.276795102469005 no 2457 0.249316278636256 3657 3696 A tricyclic antidepressant.
SGTC_1705 st027868 56.3335 µM -0.67740769388024 0.276521440839218 no 2458 0.249073659047481 3648 292948
SGTC_2804 7954240 19.48 µM -0.678869827650248 0.275998628209105 no 2459 0.248610172452482 3640 828705
SGTC_2832 7992762 51.95 µM -0.681707722573699 0.274985274570661 no 2460 0.247711891656409 3562 2985177
SGTC_567 1080-0542 68.4 µM -0.681720068373642 0.274980870148281 no 2461 0.247707987622052 3583 5950415
SGTC_1134 3477-0009 42.5 µM -0.681770309996527 0.274962946570797 no 2462 0.247692100369848 3689 3973534
SGTC_610 4215-0184 155 µM -0.682861233970688 0.274573904088217 no 2463 0.247347265959154 3667 5605015
SGTC_1919 st067113 52.3 µM -0.683477658588451 0.274354196470174 no 2464 0.247152531427912 3656 1268243
SGTC_1815 st051655 58.2 µM -0.683562149858631 0.274324088642885 no 2465 0.247125846205234 3621 5984156
SGTC_1995 st072814 61.1 µM -0.683648854911821 0.274293193646705 no 2466 0.247098463396695 3618 5769371
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.683789610390103 0.274243042904749 no 2467 0.247054014076855 3670 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2813 7971799 71.43 µM -0.683930498248888 0.274192849530972 no 2468 0.247009527236389 3678 2234054
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.684393356660379 0.274027981354475 no 2469 0.24686340494386 3656 2374 Ca(2+)-ATPase inhibitor.
SGTC_227 fluconazole 33.516 µM -0.686597415136343 0.27324357789202 no 2470 0.24616822891035 3631 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_83 0170-0301 39.027 µM -0.688068858790698 0.272720524982144 no 2471 0.245704709957794 3611 3089716
SGTC_1985 st071382 65.5 µM -0.688128894947958 0.272699194530374 no 2472 0.245685807944569 3688 6123237
SGTC_352 k048-0007 5.11 µM -0.688213968483595 0.272668969880591 no 2473 0.245659024404707 3643 6811911
SGTC_2894 9048625 32.47 µM -0.689371129181396 0.272258022755847 no 2474 0.24529487346211 3708 4092861
SGTC_2906 7926292 26.41 µM -0.690058092302927 0.272014204458063 no 2475 0.245078827981331 3640 2966319
SGTC_2859 9028643 45.46 µM -0.691583864587858 0.271473063073353 no 2476 0.244599348749542 3623 17151580
SGTC_3040 9091894 49.47 µM -0.693151044841002 0.27091779449788 no 2477 0.244107383376604 3587 25236966
SGTC_1773 st048542 73.5835 µM -0.69330398978874 0.270863634850205 no 2478 0.244059399871469 3610 3237138
SGTC_2361 9034121 116 µM -0.696396787824848 0.269769598628668 no 2479 0.24309018706459 3674 6496917
SGTC_410 α-linolenic acid 100 µM -0.696540398169825 0.269718852188791 no 2480 0.243045233461741 3720 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3163 9099914 49.47 µM -0.696713822970025 0.269657576826768 no 2481 0.242990953188018 3676 16268368
SGTC_333 3486-0131 40.1 µM -0.696916962681215 0.26958581130538 no 2482 0.242927380776514 3732 6744690
SGTC_906 1165-0455 526 µM -0.697072627263776 0.269530824350304 no 2483 0.242878671759131 3659 3252859
SGTC_1244 0416-0015 52.5 µM -0.697093081931313 0.269523599361637 no 2484 0.242872271680274 3683 96201
SGTC_1864 st057645 30.4 µM -0.698047652402767 0.269186534392277 no 2485 0.242573696813926 3699 688666
SGTC_957 1187-1561 14.1 µM -0.698513717858808 0.269022040548314 no 2486 0.242427991003409 3652 1538454
SGTC_278 4092-0821 23.9 µM -0.698874594694143 0.268894706800909 no 2487 0.242315202837008 3662 877900
SGTC_1602 st001878 87.6 µM -0.699019309350084 0.26884365339612 no 2488 0.242269981819901 3683 595405 YLR310C CDC25
SGTC_3171 9103192 49.47 µM -0.699207920492126 0.268777121202717 no 2489 0.24221105071849 3712 13018434
SGTC_429 1112-0049 25.5 µM -0.699770060258557 0.26857887662306 no 2490 0.242035457589806 3650 2836170
SGTC_931 2812-0076 566 µM -0.700005112016861 0.268496004910197 no 2491 0.241962055978557 3696 3450959
SGTC_999 SEC7.066 22.7 µM -0.70034376294626 0.268376630058532 no 2492 0.241856323807026 3680 740511 YDR170C SEC7
SGTC_3251 9135047 49.47 µM -0.701510564970004 0.267965535490639 no 2493 0.241492221837021 3659 17682963
SGTC_960 1222-0186 7.7 µM -0.701568972809632 0.267944965232967 no 2494 0.241474003428063 3684 3126296
SGTC_2321 7390090 138.78 µM -0.701803573624775 0.267862350788133 no 2495 0.241400834923456 3639 649046
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.702152156751427 0.267739621285228 no 2496 0.241292139278192 3677 551469
SGTC_2709 st078560 56 µM -0.702529215914313 0.267606897819801 no 2497 0.241174594147619 3684 17250903
SGTC_1928 4'-methoxychalcone 40.3 µM -0.703219315700067 0.267364071114134 no 2498 0.240959541785297 3701 641818
SGTC_1387 3342-1166 1.8 µM -0.703925505229737 0.267115698005855 no 2499 0.240739583471643 3668 3418228
SGTC_404 fumagillin 50 µM -0.704321585676786 0.266976444012833 no 2500 0.240616263321613 3672 12015870 A methionine aminopeptidase binder.
SGTC_1373 2887-0003 58.5 µM -0.70473447916945 0.266831317931968 no 2501 0.240487745027393 3680 776948
SGTC_3311 9131146 2.8755 µM -0.705321618160853 0.266625015749896 no 2502 0.240305055021557 3697 4900406 YPR165W RHO1
SGTC_139 0099-0334 718.624 µM -0.705495463218748 0.266563947540059 no 2503 0.240250977138183 3723 97690
SGTC_3332 9141069 11.198 µM -0.706129893673568 0.266341145134001 no 2504 0.240053681488265 3643 17332883
SGTC_3226 9131256 49.47 µM -0.706491976428342 0.266214029384741 no 2505 0.239941120331952 3592 17178073
SGTC_2731 amoxapine 43.43 µM -0.708006057141664 0.265682816696414 no 2506 0.239470747999838 3727 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2886 9058944 51.95 µM -0.708308775082826 0.26557667312095 no 2507 0.239376764476186 3558 4949929
SGTC_2044 5102272 200 µM -0.709614204019321 0.265119190244661 no 2508 0.238971704483038 3674 592666
SGTC_3212 9128307 49.47 µM -0.711014265435745 0.26462898898557 no 2509 0.238537697921031 3672 27243542
SGTC_1043 0916-0009 19.3 µM -0.712514674118785 0.264104165564968 no 2510 0.238073063969006 3719 3101130
SGTC_1736 st036774 51 µM -0.713343838316676 0.263814362385449 no 2511 0.237816508320719 3752 1272247
SGTC_557 1315-0110 16.2 µM -0.713667450368174 0.263701299964536 no 2512 0.237716419125678 3703 6833801
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.714400516979538 0.263445275212169 no 2513 0.237489776200163 3738 6708784 An antioxidant flavonoid
SGTC_493 zm226600 134 µM -0.714411204395605 0.263441543552694 no 2514 0.237486472838682 3710 5240098 A potassium channel opener. YCR052W RSC6
SGTC_326 k292-0812 17.5 µM -0.714655758411851 0.263356161501162 no 2515 0.237410890803323 3668 3579357
SGTC_435 c-PAF 6.7 µM -0.715134238749422 0.263189148761068 no 2516 0.237263049540324 3720 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.715417168730794 0.263090417999084 no 2517 0.237175653388661 3712 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2036 5160441 105 µM -0.715811209131703 0.262952945876341 no 2518 0.237053965062251 3703 134534 YIL048W NEO1
SGTC_820 1582-0060 59.9 µM -0.716497669360366 0.26271354257936 no 2519 0.236842053048965 3706 3848840
SGTC_3035 9091303 49.47 µM -0.71759335652489 0.2623316523737 no 2520 0.236504027560733 3742 25237002
SGTC_531 3788-1495 174 µM -0.71778699108068 0.262264192665587 no 2521 0.23644431785855 3674 2896655
SGTC_2003 4023581 200 µM -0.718911246083775 0.261872692806054 no 2522 0.236097803384805 3733 16641307
SGTC_1224 0823-0416 294 µM -0.718931238817485 0.261865733440129 no 2523 0.236091643817802 3738 3598164
SGTC_2693 st077581 40.7 µM -0.719871705358531 0.261538469170925 no 2524 0.235801995270436 3745 25238761
SGTC_1778 st046819 58.9 µM -0.719987017289939 0.261498357291311 no 2525 0.235766494541588 3749 671715
SGTC_549 1661-1316 519 µM -0.720445403587709 0.26133893637513 no 2526 0.235625401711774 3726 2857282
SGTC_1710 st031758 61.5 µM -0.721172653488009 0.261086110594265 no 2527 0.235401647363928 3726 5394341
SGTC_1876 myriocin 605 nM -0.721574502710261 0.260946463124829 no 2528 0.235278059976888 3725 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_640 3381-0960 37.1 µM -0.722432643076583 0.260648377607815 no 2529 0.235014261740278 3745 1745025
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.723040738272217 0.260437254479248 no 2530 0.234827428073438 3766 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_874 0599-0792 117 µM -0.723081404460039 0.260423138824482 no 2531 0.234814936556219 3726 765305
SGTC_1770 st043884 66.3 µM -0.723268879321768 0.260358069455201 no 2532 0.234757354264281 3705 670149
SGTC_1622 st003707 19.4 µM -0.724980139150478 0.259764507345783 no 2533 0.23423210739646 3756 10140899
SGTC_3005 9076496 71.4286 µM -0.725453857486678 0.259600318415815 no 2534 0.234086821350095 3728 21368410
SGTC_1220 1838-0075 193 µM -0.725890865589003 0.25944890063619 no 2535 0.233952838338793 3679 5529645
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.726320635123114 0.259300035431731 no 2536 0.233821116056972 3671 279621
SGTC_492 tmb-8 126 µM -0.728781412597315 0.258448512649938 no 2537 0.233067691622276 3612 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1703 st026983 48.3 µM -0.729160517529267 0.258317456787994 no 2538 0.232951739755651 3731 1104023
SGTC_2940 9060638 45.86 µM -0.729165116439836 0.258315867164711 no 2539 0.23295033334376 3736 4027022
SGTC_2033 5192550 145 µM -0.730493104984194 0.2578570572524 no 2540 0.232544413029195 3732 182073
SGTC_1209 2323-2347 50.3 µM -0.732612237056486 0.257125790054801 no 2541 0.231897482698249 3685 5412760
SGTC_661 1304-0007 33.6 µM -0.732812198215509 0.257056843454486 no 2542 0.231836490191778 3740 3117130
SGTC_589 1227-0070 34.1 µM -0.734256650968239 0.256559081956188 no 2543 0.231396166173274 3736 2841384
SGTC_1312 1218-2183 165 µM -0.734621098901632 0.256433571782276 no 2544 0.231285142335712 3737 6744073
SGTC_1321 1326-2144 215 µM -0.73571196924987 0.256058084363558 no 2545 0.230953001969679 3732 3513030
SGTC_445 e6 berbamine 66 µM -0.736190844803796 0.255893341704153 no 2546 0.230807281530585 3811 6610268 A calcium/calmodulin antagonist.
SGTC_98 0074-0023 107.663 µM -0.736866979791159 0.255660832116793 no 2547 0.23060162308115 3692 3563821
SGTC_2391 6285546 200 µM -0.73732233329178 0.255504307152101 no 2548 0.230463176959271 3720 846083
SGTC_920 mycophenolic acid 780.421 nM -0.737681181892397 0.255380990436636 no 2549 0.230354105024415 3763 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3077 9117319 49.47 µM -0.737964999663162 0.255283479764376 no 2550 0.230267859135623 3716 17154678
SGTC_2507 purpurin 79.67 µM -0.73971845045355 0.254681482231917 no 2551 0.229735425177913 3745 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1641 st009299 47.1 µM -0.740382521280899 0.254453686612163 no 2552 0.229533960733931 3674 4046054
SGTC_996 3970-0799 1.8 µM -0.743560029188728 0.253365188338222 no 2553 0.228571346173578 3800 6615648 YGL040C HEM2
SGTC_2249 haloperidol 116.36 µM -0.74413553304662 0.253168303834592 no 2554 0.228397242206698 3741 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3006 9075424 71.4286 µM -0.744403386842145 0.25307669634219 no 2555 0.228316235314207 3741 7465181
SGTC_1322 1348-1070 12 µM -0.746930735000105 0.252213188408926 no 2556 0.227552686132373 3714 6758089
SGTC_888 0916-0002 6.97 µM -0.747033493858585 0.252178112141988 no 2557 0.227521671615207 3826 2802138 YIL048W NEO1
SGTC_1691 st019933 84.6 µM -0.749541910031754 0.251322674295154 no 2558 0.226765324108719 3714 6176082
SGTC_31 0508-1974 57.237 µM -0.750298748948388 0.25106487332053 no 2559 0.226537397965076 3705 6810525
SGTC_2839 9003951 25.97 µM -0.750965028215882 0.250838035401942 no 2560 0.226336851443859 3750 2990634
SGTC_1942 st076330 65.2 µM -0.752162794466728 0.250430523231789 no 2561 0.225976582460716 3783 24208414
SGTC_2123 5259487 200 µM -0.752578420791748 0.250289198067027 no 2562 0.225851644500292 3737 2173474
SGTC_2967 9089538 49.85 µM -0.754682223660371 0.24957449248703 no 2563 0.22521983752309 3774 728216
SGTC_760 0568-0725 82.9 µM -0.755273022117515 0.249373981134016 no 2564 0.225042591133852 3811 3916171
SGTC_1393 3470-5649 58.2 µM -0.756608743765311 0.248920965803902 no 2565 0.224642150666111 3731 4108395
SGTC_1119 parthenolide 318.541 nM -0.757143768993805 0.248739632794605 no 2566 0.224481867100796 3902 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2690 usnic acid 100 µM -0.758107087227792 0.248413318334891 no 2567 0.224193438628974 3780 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3198 9112019 49.47 µM -0.758662351870512 0.248225331676 no 2568 0.224027281715504 3809 45595555
SGTC_268 camptothecin 39.6153 µM -0.759712845979448 0.247869891083855 no 2569 0.223713124214867 3755 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1862 st057513 3.81 µM -0.760801989295722 0.247501660360133 no 2570 0.223387673025927 3758 5393163
SGTC_1159 4092-0538 61.2 µM -0.760896279255022 0.247469795425415 no 2571 0.22335951054941 3801 717301
SGTC_2437 5741531 144.16 µM -0.762232792152026 0.247018361812926 no 2572 0.222960538904139 3802 2262990
SGTC_679 0422-0091 41.4 µM -0.762684765008644 0.246865798812372 no 2573 0.222825709285793 3776 627384 YHR062C RPP1
SGTC_828 2074-0507 139 µM -0.762685175866949 0.246865660150497 no 2574 0.22282558674234 3820 X828
SGTC_885 0865-0106 16.8 µM -0.76287628388004 0.246801167019362 no 2575 0.222768590631935 3712 2793380
SGTC_3350 9150499 3.57 µM -0.76356908177317 0.246567444478988 no 2576 0.222562040047612 3755 4910996 YPR165W RHO1
SGTC_1004 4084-0029 199 µM -0.763850274046549 0.246472615194635 no 2577 0.222478236619777 3807 716894 YLR208W SEC13
SGTC_2099 5377090 177.372 µM -0.765797079547095 0.245816610851327 no 2578 0.221898526099288 3786 2243829
SGTC_2138 5575593 77.673 µM -0.765838276707169 0.245802739004651 no 2579 0.221886267931998 3760 762213
SGTC_1089 terbinafine 2.25 µM -0.766574378432023 0.24555495077252 no 2580 0.221667306914525 3778 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1513 0337-0559 19 µM -0.767758867876713 0.245156507093676 no 2581 0.221315227682494 3764 775073
SGTC_259 usnic acid 108.925 µM -0.76777300436661 0.245151753900481 no 2582 0.221311027665419 3846 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_989 1501-0895 10.3 µM -0.768499632180109 0.244907502413185 no 2583 0.221095204551731 3751 2830112
SGTC_107 0358-0022 2.6945 µM -0.76856782801656 0.244884585524523 no 2584 0.221074955196888 3806 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1729 st035615 45.989 µM -0.769192467598288 0.244674732049632 no 2585 0.220889530670492 3863 17385451
SGTC_1983 st071813 46.9 µM -0.769931032703793 0.244426729226319 no 2586 0.220670402224102 3846 11838595
SGTC_1017 4239-0030 168 µM -0.770131564188877 0.244359416134813 no 2587 0.220610927070842 3838 1149593
SGTC_357 1325-0123 420 µM -0.770776503187565 0.24414299499901 no 2588 0.220419708430464 3789 1098503
SGTC_2115 tiliquinol 12.7705 µM -0.770978617628021 0.244075193061064 no 2589 0.2203598028638 3788 71208 A bioactive hydroxyquinoline.
SGTC_1478 0453-0656 35.7 µM -0.771535197166383 0.243888533662048 no 2590 0.220194884111958 3809 5258496
SGTC_1590 st077108 57.8 µM -0.771614050420238 0.243862094973854 no 2591 0.220171525018597 3735 5489485
SGTC_387 norethindrone acetate 66.7 µM -0.772323363655417 0.243624339061187 no 2592 0.219961465514478 3791 541197
SGTC_1706 st031321 9.9705 µM -0.772521480699019 0.243557954242291 no 2593 0.219902814712302 3818 6103185
SGTC_1282 0886-0010 32.4 µM -0.773111244683544 0.24336039468479 no 2594 0.219728273423383 3861 2836211 YNL267W PIK1
SGTC_2680 butyl paraben 22.24 µM -0.773223682304469 0.243322740081781 no 2595 0.219695006417533 3830 7184 An antifungal and steroid mimetic.
SGTC_2130 NSC 7 2.4545 µM -0.773760284340348 0.243143079048828 no 2596 0.219536281397723 3829 21448
SGTC_1749 st037932 54.2 µM -0.773991395855448 0.243065722144997 no 2597 0.219467939712803 3822 594497
SGTC_1374 2889-5571 141 µM -0.775335613287239 0.242616053970179 no 2598 0.219070685284943 3827 2853281
SGTC_3294 9122953 26.2835 µM -0.775531021486117 0.242550723458429 no 2599 0.219012971055755 3789 16459826
SGTC_2889 9059656 51.95 µM -0.77556800271125 0.242538360656583 no 2600 0.219002049556024 3880 3949838
SGTC_898 1000-0849 28.3 µM -0.776968048529914 0.242070577280853 no 2601 0.218588810748119 3737 6751807
SGTC_2543 pimpinellin 60.67 µM -0.778518378141569 0.241553152440089 no 2602 0.218131738251488 3698 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3061 glucosamine 200 µM -0.782016908758462 0.240387722692967 no 2603 0.217102318262453 3711 91431 and experimental redox chemotherapeutic
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.782574702663758 0.240202194018766 no 2604 0.216938450848924 3834 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2026 5148700 152 µM -0.784185399652309 0.239666895943623 no 2605 0.216465665466204 3801 79838
SGTC_2976 9009005 19.48 µM -0.784725072746239 0.239487687032486 no 2606 0.21630738951631 3792 2993148
SGTC_2220 6782180 200 µM -0.786753100811542 0.238814895576667 no 2607 0.215713206340563 3718 833803
SGTC_12 0849-0099 9.267 µM -0.787633700233699 0.238523081934928 no 2608 0.215455498236011 3722 6071388
SGTC_464 bw-b 70c 158 µM -0.787692795677456 0.238503505837729 no 2609 0.215438210305525 3879 5353454
SGTC_1943 st076331 65.2 µM -0.790023979669688 0.237731974404541 no 2610 0.214756882075781 3847 24208415
SGTC_1050 3232-1156 69.3 µM -0.792527752005134 0.236904850124078 no 2611 0.214026508296915 3809 700529
SGTC_844 0330-0132 15.3 µM -0.793125795921581 0.236707519910967 no 2612 0.213852267452642 3850 2828079
SGTC_2910 7948405 25.97 µM -0.793654640289855 0.236533098087909 no 2613 0.213698256821704 3718 2971328
SGTC_887 0885-0007 9.62 µM -0.795231840178933 0.236013331116909 no 2614 0.213239326805055 3907 5719458
SGTC_663 1486-0733 13.9 µM -0.796321423132639 0.235654626438269 no 2615 0.212922618392728 3838 722445 YPR165W RHO1
SGTC_360 0957-0399 1.01 µM -0.796441205861353 0.235615210781841 no 2616 0.21288781797553 3850 6752301 YPR165W RHO1
SGTC_978 1416-0512 87.4 µM -0.797898206661556 0.235136061944342 no 2617 0.212464782086424 3889 6814003
SGTC_3329 9141233 27.5565 µM -0.798843568037604 0.234825458790908 no 2618 0.212190562093172 3810 4909101 YNL103W MET4
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.799025768330044 0.234765622061309 no 2619 0.212137735234193 3881 688664
SGTC_1032 k061-1018 98.7 µM -0.800836689307759 0.234171352670498 no 2620 0.211613097888135 3968 4005393
SGTC_1288 0973-0013 65.5 µM -0.801582456614711 0.233926865017632 no 2621 0.211397264512874 3883 4315430
SGTC_1357 1503-1303 39.5 µM -0.801661806183951 0.233900859881802 no 2622 0.211374307454026 3809 292895
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.802148714780404 0.233741321007902 no 2623 0.211233469233655 3839 2724 A muscle relaxant with antifungal properties.
SGTC_1523 st012844 44.7 µM -0.802969124709769 0.233472644670747 no 2624 0.210996290222777 3966 4274103
SGTC_2880 9042983 58.44 µM -0.803802003999634 0.233200060059108 no 2625 0.210755666115364 3866 6464714
SGTC_2629 bisabolol 100 µM -0.803802790818553 0.233199802632676 no 2626 0.210755438874518 3848 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3331 9141060 1.957 µM -0.804778825758433 0.232880591187333 no 2627 0.210473661308852 3818 4906567 YPR165W RHO1
SGTC_1508 1080-0625 72.9 µM -0.805703433807157 0.232578422890232 no 2628 0.210206934557196 3744 767111
SGTC_3276 9139060 49.47 µM -0.807296864431145 0.232058190648602 no 2629 0.209747735045978 3912 4870619
SGTC_2829 7992743 58.44 µM -0.807500057139636 0.231991897747333 no 2630 0.209689220804972 3905 16462845
SGTC_1229 0139-0193 12.2 µM -0.808047184706529 0.231813446366222 no 2631 0.209531709956004 3867 3090752
SGTC_527 4476-4215 268 µM -0.809784367291075 0.231247353225658 no 2632 0.209032059416736 3851 4418754
SGTC_3037 9091026 49.47 µM -0.80984698247327 0.231226963317855 no 2633 0.209014063074487 3845 25236398 YIL048W NEO1
SGTC_2533 agelasine 13.65 µM -0.810817330999244 0.23091110881897 no 2634 0.208735290121121 3884 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1030 k029-0042 36.7 µM -0.811920165106094 0.230552422105736 no 2635 0.208418721372574 3848 6080581
SGTC_1686 st019653 115.5 µM -0.813157230613526 0.230150448653898 no 2636 0.208063958640717 3810 97252
SGTC_706 4262-0057 46.9 µM -0.813569345796749 0.230016622600434 no 2637 0.207945852416317 3835 883298
SGTC_534 k292-0788 63.4 µM -0.813662801385074 0.22998628085066 no 2638 0.20791907490939 3850 4146317
SGTC_34 0469-0683 81.75 µM -0.814036666244754 0.229864922458541 no 2639 0.207811973068633 3837 3690923
SGTC_3319 9138450 16.7555 µM -0.81428577373805 0.229784080833774 no 2640 0.207740628820694 3794 2029690
SGTC_1012 4112-3522 18 µM -0.816560861002821 0.229046495092732 no 2641 0.207089714846056 3823 3112398
SGTC_662 k832-1615 104 µM -0.81810076352365 0.228548011733005 no 2642 0.20664982647134 3904 5878478
SGTC_3306 9127676 59.7925 µM -0.818712505363044 0.228350153434155 no 2643 0.206475230055658 3865 41905287
SGTC_1248 0469-0687 58.6 µM -0.818784656599462 0.228326823596914 no 2644 0.206454643231459 3863 4017482
SGTC_573 3702-0553 84.7 µM -0.819503952784102 0.228094315077935 no 2645 0.206249473832081 3814 1222756
SGTC_3183 9108214 49.47 µM -0.819740151930366 0.22801799405794 no 2646 0.206182127623907 3810 4974831
SGTC_655 k060-0012 42 µM -0.820145212606156 0.22788714369246 no 2647 0.206066665177691 3867 5994525
SGTC_2565 isoliquiritigenin 100 µM -0.820535990056278 0.227760947415241 no 2648 0.205955310507954 3948 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.821146998663421 0.227563709323417 no 2649 0.20578127103521 3830 2346 DNA damaging agent; causes G2/M arrest.
SGTC_197 4544-0043 41.561 µM -0.822514258521138 0.227122696347969 no 2650 0.20539213750013 3852 896523
SGTC_172 1112-0046 2.638 µM -0.822999056541681 0.226966439354942 no 2651 0.205254264970964 3829 2802135 YIL048W NEO1
SGTC_215 1287-0124 461.5 µM -0.823768900845815 0.226718432688702 no 2652 0.205035440662665 3882 5560863
SGTC_2641 levomentholum 100 µM -0.825176139411522 0.226265483864764 no 2653 0.204635798892528 3823 16666
SGTC_2283 7944793 200 µM -0.825733789696089 0.22608613412288 no 2654 0.204477560050639 3902 2970533
SGTC_2561 acetosyringone 100 µM -0.825785488247304 0.226069511067152 no 2655 0.204462893759595 3882 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2955 9076254 12.21 µM -0.826394868911088 0.225873624014504 no 2656 0.204290066584647 3820 16459619
SGTC_659 k018-0002 107 µM -0.828837733655858 0.225089322926382 no 2657 0.203598116568016 3850 6797879 YHR007C ERG11
SGTC_569 4130-2812 160 µM -0.831033938167296 0.2243855331819 no 2658 0.202977228646031 3707 743552
SGTC_903 1134-0042 114 µM -0.83338256613569 0.223634282194925 no 2659 0.202314501936716 3887 701009
SGTC_2932 9016711 44.54 µM -0.833662569059661 0.22354481373509 no 2660 0.202235578235663 3895 7117328
SGTC_1672 st016598 6.51 µM -0.834164047252618 0.223384628866533 no 2661 0.202094273912668 3916 4665860 YNL267W PIK1
SGTC_2238 6671620 73.2395 µM -0.836176188859804 0.222742556915779 no 2662 0.201527895877015 3837 729941
SGTC_864 0469-0573 172 µM -0.837904936649613 0.222191756573977 no 2663 0.201042047991492 3873 689425
SGTC_3105 9121040 49.47 µM -0.838046231810434 0.222146772581742 no 2664 0.201002369432413 3701 41448907
SGTC_2958 9077254 16.72 µM -0.84111917935346 0.221169728137367 no 2665 0.200140585756947 3944 16457351
SGTC_1452 4194-0072 190 µM -0.841879634578399 0.220928321233173 no 2666 0.199927665424868 3916 1343545
SGTC_1713 st033146 12.748 µM -0.844513868132095 0.220093249622667 no 2667 0.199191158565236 3849 674619
SGTC_2836 9010338 19.48 µM -0.844533379709665 0.220087071070275 no 2668 0.199185709416496 3904 2994051
SGTC_2992 9074591 71.4286 µM -0.847442250676836 0.219167059274055 no 2669 0.19837433146587 3858 17741321
SGTC_2284 7945075 39.21 µM -0.848136169651605 0.218947915073357 no 2670 0.19818107012101 3951 1245402
SGTC_685 1278-0033 54.9 µM -0.849173239062688 0.218620636757174 no 2671 0.197892450915542 3921 3590572
SGTC_821 1114-0266 29.2 µM -0.849814442214331 0.218418426866166 no 2672 0.197714129450413 3936 3123235
SGTC_2833 9001315 45.46 µM -0.851154956468982 0.217996030346329 no 2673 0.197341640294549 3891 2989378
SGTC_2377 9073351 62.6 µM -0.851765415290655 0.2178038307305 no 2674 0.197172152641709 3880 7337946 YHR072W ERG7
SGTC_2459 5811157 9.22 µM -0.853120242317818 0.217377620225071 no 2675 0.196796313541197 3882 2870684 YBR192W RIM2
SGTC_607 4491-0986 66.8 µM -0.853641415313117 0.217213794498214 no 2676 0.196651851891026 3922 698981 YDR232W HEM1
SGTC_2871 9038510 12.99 µM -0.85603583861666 0.216462047623159 no 2677 0.19598897813925 3859 4945164
SGTC_1979 st071809 45.3 µM -0.856479151167758 0.216323031733363 no 2678 0.19586640007698 4005 4976333
SGTC_300 r073-0011 5.04 µM -0.856869382611216 0.216200704029684 no 2679 0.195758537705836 3902 2735780
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.858095223966554 0.215816694359328 no 2680 0.19541994219625 3889 4620898
SGTC_943 3253-1379 105 µM -0.858607018890527 0.215656485440276 no 2681 0.195278682198821 3880 668464
SGTC_1404 3909-7820 48.3 µM -0.858763112440592 0.215607636667157 no 2682 0.195235611326478 3856 23741373
SGTC_1390 3413-2614 145 µM -0.859093690717491 0.215504204870319 no 2683 0.195144413967216 3956 3421432
SGTC_1267 0828-0272 9.49 µM -0.860066751110607 0.215199919446266 no 2684 0.194876123955783 3991 745334
SGTC_3144 9087057 49.47 µM -0.860799806510201 0.214970850701465 no 2685 0.194674155802971 3766 17249618
SGTC_1534 6-azauridine 81.6 µM -0.86207825065699 0.214571695213299 no 2686 0.194322229440387 3952 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.862431466937485 0.2144614901275 no 2687 0.19422506543707 3923 77254
SGTC_134 0269-0018 6.916 µM -0.863480994414399 0.21413422702634 no 2688 0.193936532268923 3887 4378915
SGTC_1325 1431-0015 227 µM -0.863823026595083 0.214027637549527 no 2689 0.193842558198642 3893 1103340
SGTC_2734 clemastine 41.6 µM -0.863861324208148 0.214015704564557 no 2690 0.193832037576054 3934 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_462 ag-879 158 µM -0.864505433386881 0.213815067450218 no 2691 0.193655148428698 3958 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_734 2023-0417 80 µM -0.864825155335963 0.213715516193824 no 2692 0.193567381028193 3938 3935732
SGTC_1678 st019265 80.2 µM -0.865443570745501 0.213523037917296 no 2693 0.193397687650971 3920 5367020
SGTC_1835 st008666 49.2 µM -0.865500422059873 0.213505348341004 no 2694 0.193382092189845 3860 690455
SGTC_2211 7117706 200 µM -0.866471424154647 0.213203347978766 no 2695 0.193115845236776 3843 822771
SGTC_768 0384-0033 77.3 µM -0.867378475223996 0.212921462801788 no 2696 0.192867335810281 3915 3965305 YMR134W ERG29
SGTC_122 0236-0016 402.397 µM -0.869257163785751 0.212338313106519 no 2697 0.192353243546096 3944 6808838
SGTC_1386 3228-0095 33.8 µM -0.869435035188934 0.212283149780396 no 2698 0.192304613528741 3951 870181
SGTC_639 0833-0042 114 µM -0.869686160951023 0.212205282314103 no 2699 0.192235968582917 3915 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2416 tofa 880 nM -0.869716069352015 0.212196009621686 no 2700 0.192227794153956 3965 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2872 9044037 25.97 µM -0.869915531515167 0.212134175152013 no 2701 0.192173283494821 3924 6465195
SGTC_246 cycloheximide 667 µM -0.871382489298944 0.211679733181181 no 2702 0.191772671808072 3792 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1191 1487-1166 10.6 µM -0.871714649812911 0.21157691390522 no 2703 0.191682033102193 3979 3955771
SGTC_1048 3161-0300 24.5 µM -0.873557631718771 0.211006955868202 no 2704 0.19117960394172 3922 2165101
SGTC_1450 4112-4260 37.6 µM -0.874181380369806 0.210814260273215 no 2705 0.191009742171394 3881 1633175
SGTC_2087 5276107 200 µM -0.875104615227646 0.210529233472641 no 2706 0.190758493059576 3902 144405
SGTC_78 0336-0123 156.75 µM -0.875225585742509 0.210491903469363 no 2707 0.190725587180827 3772 6765896
SGTC_2921 7974240 10.71 µM -0.87617026082135 0.210200522089254 no 2708 0.190468740568335 4024 2979074 YDR527W RBA50
SGTC_962 1254-0300 21.5 µM -0.877180583269542 0.209889154352959 no 2709 0.190194280337015 3916 7340576
SGTC_2250 alverine citrate 130 µM -0.877542021254159 0.209777829917703 no 2710 0.19009615255623 3843 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3197 9113331 49.47 µM -0.877802191954649 0.209697717727874 no 2711 0.190025537367532 3946 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_471 1-acyl-paf 4 µM -0.87826877615667 0.209554091422842 no 2712 0.189898938089056 3869 16759367
SGTC_401 neomycin 50 µM -0.878760594879392 0.209402759961542 no 2713 0.189765548026516 3919 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1076 itraconazole 331 nM -0.878829785438682 0.209381475350567 no 2714 0.189746786929832 3932 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_77 0828-0286 12.516 µM -0.879981119357879 0.209027485382776 no 2715 0.189434768904912 3887 745345
SGTC_2968 9090663 33.37 µM -0.88003905503017 0.209009681757917 no 2716 0.189419076357907 3916 25236811
SGTC_689 0833-0039 98 µM -0.881713403579656 0.208495540639718 no 2717 0.188965905412208 3913 5374726
SGTC_3296 9122258 64.045 µM -0.881924609253103 0.208430738863116 no 2718 0.188908789000219 3960 4730474
SGTC_1299 1079-1439 3.74 µM -0.882634673881568 0.208212965117205 no 2719 0.188716844019717 3897 323161
SGTC_2605 digitonin 300 nM -0.882835411730034 0.208151424039997 no 2720 0.188662602280472 3966 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_719 2810-4230 27.3 µM -0.882935264288641 0.208120815804109 no 2721 0.188635624518642 3934 721079
SGTC_2165 5727197 32.143 µM -0.883116253132229 0.208065343283921 no 2722 0.188586731744723 4122 1361712
SGTC_3070 9117005 49.47 µM -0.88656474258493 0.207010060265541 no 2723 0.187656641535818 3992 8779016
SGTC_1604 st002052 72.4 µM -0.887205900886947 0.206814207140518 no 2724 0.187484028023299 4012 6254834 YHR062C RPP1
SGTC_1552 6-methylflavone 10.6 µM -0.887386199962576 0.206759151370514 no 2725 0.187435505342727 3862 689013
SGTC_330 1488-0319 80.1 µM -0.889025057992876 0.206259110944793 no 2726 0.186994806485489 3995 6846614
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.890164662958286 0.205911823104931 no 2727 0.186688737993364 3997 94937 An inhibitor of serotonin biosynthesis.
SGTC_1962 st076595 64.5 µM -0.891838864841425 0.205402249631778 no 2728 0.186239653426862 3973 279619
SGTC_2564 betulinic acid 100 µM -0.892175860466492 0.205299769570728 no 2729 0.186149339394401 4017 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1968 st069590 43.6 µM -0.894678933339254 0.204539538515036 no 2730 0.18547937165403 3976 6384066
SGTC_264 promethazine 12.5 mM -0.8972308323138 0.203766205211929 no 2731 0.184797878030792 3895 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_291 SEC14.278 35.5 µM -0.897586019675327 0.203658706774928 no 2732 0.18470314753691 3989 1068044
SGTC_2656 pseudo-anisatin 100 µM -0.898276681218681 0.203449772981674 no 2733 0.184519030614321 3996 6708809 A neurotoxin.
SGTC_1408 3909-7976 48.8 µM -0.900725683637971 0.202709950230365 no 2734 0.183867094694043 4020 24152374
SGTC_1165 k072-0275 30.3 µM -0.900968593361182 0.202636657012667 no 2735 0.183802509283147 3943 6153523 YGL055W OLE1
SGTC_1633 st005664 67.9 µM -0.90227703474994 0.20224213313992 no 2736 0.183454860915095 3981 2063822
SGTC_545 4218-0007 221 µM -0.903036136993534 0.202013457874642 no 2737 0.183253358073608 3980 2840508
SGTC_2902 5787006 60.46 µM -0.904636567033144 0.201531844720138 no 2738 0.182828978184694 3941 591003
SGTC_1020 4335-0961 93.3 µM -0.907739923708485 0.200599922475554 no 2739 0.182007822737663 3913 669075
SGTC_1469 k284-2957 126 µM -0.908163552257974 0.200472909989737 no 2740 0.18189590878514 3946 23884841
SGTC_1687 st020778 55.3625 µM -0.909234871774529 0.200151922126055 no 2741 0.181613080289846 3987 4259299
SGTC_2703 st077852 53.4 µM -0.909553427674844 0.200056536286218 no 2742 0.181529034600052 4028 6281836
SGTC_2771 fluoxetine 41.05 µM -0.910068870989419 0.199902253942998 no 2743 0.181393095004523 3966 3386 A selective serotonin reuptake inhibitor.
SGTC_1068 loratadine 26.9 µM -0.911908116342319 0.199352315014548 no 2744 0.180908544310635 4024 3957 A H1 histamine antagonist.
SGTC_730 1436-0052 41.2 µM -0.912260110377657 0.199247171868934 no 2745 0.180815903757797 3994 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_873 0591-4978 488 µM -0.912959150444516 0.19903846263111 no 2746 0.180632013095291 4090 3305145
SGTC_2719 novobiocin 32.65 µM -0.913839820102248 0.198775712662025 no 2747 0.180400509652666 3985 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_554 4483-2211 187 µM -0.914735969658729 0.198508559003025 no 2748 0.180165128153466 4030 747107
SGTC_1841 st054148 70 µM -0.91474998996148 0.19850438109284 no 2749 0.180161447130907 4019 675442
SGTC_2132 5317594 122.667 µM -0.915847378051012 0.19817753498888 no 2750 0.179873474976494 3960 794577
SGTC_1548 st061468 90.8 µM -0.915861370047355 0.19817336971098 no 2751 0.179869805120854 3978 390799
SGTC_1830 st055982 50.3 µM -0.918066416586052 0.197517609972921 no 2752 0.179292047790193 3888 455313 An antimicrobial agent.
SGTC_286 k060-0067 22.9 µM -0.918763014546248 0.197310721404761 no 2753 0.179109770864857 3990 5985051
SGTC_653 0203-0016 55.2 µM -0.920569912386432 0.196774686703075 no 2754 0.1786375083544 4040 295302
SGTC_1972 st070201 17.4 µM -0.921369632118623 0.196537723481267 no 2755 0.178428738987797 3975 2829099
SGTC_895 0964-0006 13.7 µM -0.921427629893904 0.196520545013094 no 2756 0.178413604465173 3981 6738897
SGTC_1775 st081588 35.1725 µM -0.92241188737737 0.196229154723403 no 2757 0.178156885754863 4008 1426443 YGL099W LSG1
SGTC_3052 9092717 49.47 µM -0.922745170428833 0.196130545386226 no 2758 0.17807001008379 4022 25237534
SGTC_2136 5328288 199.296 µM -0.923928307497057 0.195780730267959 no 2759 0.177761821828835 3998 262395
SGTC_2775 cyproheptadine 69.59 µM -0.924669515947305 0.195561772110052 no 2760 0.177568920440036 4009 2913 A selective serotonin reuptake inhibitor.
SGTC_35 0133-0054 64.071 µM -0.925113608889061 0.195430655214485 no 2761 0.177453407433618 4008 99677
SGTC_676 falcarinol 140 µM -0.925306304447038 0.195373779136593 no 2762 0.177403300156055 3968 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_933 2914-0560 114 µM -0.925436425658471 0.195335378209528 no 2763 0.17736946935042 4061 463887
SGTC_1372 2752-0194 270 µM -0.926377729235143 0.195057720506808 no 2764 0.17712485688076 3955 823334
SGTC_1247 0448-0043 5.84 µM -0.927751421559448 0.194652951267298 no 2765 0.176768264045657 4044 3089013 YGL099W LSG1
SGTC_2686 alizarin 95.37 µM -0.927968609568311 0.194589001934185 no 2766 0.176711926413096 4019 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1611 st001856 99.4 µM -0.928138773114476 0.194538907524634 no 2767 0.176667794655487 3978 647478
SGTC_3268 9137683 49.47 µM -0.92912903474664 0.194247540384458 no 2768 0.176411109519871 4042 1953228
SGTC_2735 sertaconazole 140 nM -0.930165946411196 0.193942732288676 no 2769 0.176142585262661 4119 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1924 st058459 75.1 µM -0.931449653829303 0.193565780745739 no 2770 0.175810508063989 3973 688683
SGTC_518 1021-0119 62.6 µM -0.932044736320948 0.193391190697001 no 2771 0.175656703138101 3983 1097762
SGTC_1257 0669-0121 16 µM -0.932177877416599 0.19335214185739 no 2772 0.175622303186482 4023 4307855
SGTC_2109 5483026 200 µM -0.932392285293949 0.193289268465054 no 2773 0.175566915134628 4021 759335
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.933232510746248 0.19304299935843 no 2774 0.175349966150559 4015 688751
SGTC_894 0960-0238 55.9 µM -0.935042988004508 0.192513002144087 no 2775 0.174883072944785 4010 6741907 YDL195W SEC31
SGTC_1320 1313-0481 95.3 µM -0.935299380545605 0.192438018031084 no 2776 0.174817017231393 4005 6813365 YLR208W SEC13
SGTC_1607 st000305 50.6 µM -0.935321910946605 0.192431429683166 no 2777 0.174811213366726 4030 5457690
SGTC_1741 st038134 10.228 µM -0.936039274591286 0.192221730057237 no 2778 0.174626483373001 4093 1272587
SGTC_552 k242-0005 476 µM -0.936954232533483 0.191954472629908 no 2779 0.174391050348215 4097 4088318
SGTC_426 0988-0037 14.6 µM -0.937119906270676 0.191906103985561 no 2780 0.174348441469687 4044 5383008
SGTC_1629 st005085 44.9 µM -0.937163824305124 0.191893283314327 no 2781 0.174337147498364 3982 24207091
SGTC_483 fpl-64176 144 µM -0.937240114346123 0.191871013765984 no 2782 0.174317529839823 4060 3423
SGTC_1211 1056-0033 32.3 µM -0.937487652822157 0.191798766605644 no 2783 0.174253886036166 4065 6741922
SGTC_1621 st003705 32.4 µM -0.93807001528599 0.19162886262937 no 2784 0.174104214978337 4026 24207032
SGTC_2692 st077426 47.7 µM -0.938122950617878 0.191613423342973 no 2785 0.174090614295819 4035 25238571
SGTC_581 0958-0271 211 µM -0.939131174670724 0.191319506998353 no 2786 0.173831700083835 4014 4591145
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.940007060072082 0.191064394298258 no 2787 0.173606969638807 4044 5024745
SGTC_1993 st073995 70.8 µM -0.940189387034971 0.191011315508918 no 2788 0.173560212324168 4006 3098394
SGTC_1650 st011916 45.8 µM -0.940361599785496 0.19096118946204 no 2789 0.173516056135142 3925 242528
SGTC_416 estradiol valerate 100 µM -0.941176478351541 0.190724111808637 no 2790 0.173307214262662 4047 13791 A steroid.
SGTC_1438 4092-1045 4 µM -0.94171691844128 0.190566977906197 no 2791 0.173168795401899 4006 1351342
SGTC_3001 9076041 71.4286 µM -0.941964505376979 0.190495018123992 no 2792 0.173105406342689 4001 16004211
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.94331249438476 0.190103525302327 no 2793 0.172760543450325 4030 7104
SGTC_608 k048-0125 159 µM -0.943383491173276 0.190082919611629 no 2794 0.172742392128373 4074 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_69 0096-0274 206.684 µM -0.944167036022154 0.18985559933605 no 2795 0.172542148675274 4183 6741392
SGTC_91 0417-1751 58.384 µM -0.945240148386118 0.189544541740016 no 2796 0.172268143366944 4146 6795624
SGTC_961 1252-1571 372 µM -0.946369747438366 0.189217449611006 no 2797 0.171980015031759 4036 6813498
SGTC_224 benfluorex 43.875 µM -0.94685858909444 0.18907600608182 no 2798 0.171855420975915 4034 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2386 9075165 157.42 µM -0.948951876465419 0.188471062179348 no 2799 0.171322544152397 3995 16452277
SGTC_800 3448-7362 155 µM -0.949120527184203 0.188422375435784 no 2800 0.171279657680579 4107 15991913
SGTC_2474 5321570 43.32 µM -0.950143837164392 0.188127128698708 no 2801 0.171019585670947 4044 2841384
SGTC_1788 fluconazole 20 µM -0.952910963886466 0.187330184668418 no 2802 0.170317592261297 4087 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3290 9121031 71.43 µM -0.955667541571321 0.186538357381144 no 2803 0.16962011307722 4054 17014854
SGTC_2072 5231554 129 µM -0.955910206214296 0.186468751333787 no 2804 0.169558801069948 4073 789545
SGTC_2475 5812728 15.03 µM -0.95696039492713 0.186167700176977 no 2805 0.169293622784698 3996 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_327 1273-0057 3.96 µM -0.957758974596281 0.185938977984054 no 2806 0.169092155417725 3910 3108138
SGTC_562 3772-2733 112 µM -0.960764582904955 0.185079700992149 no 2807 0.168335275118815 4059 2876874 YIL048W NEO1
SGTC_3309 9129340 25.759 µM -0.96106868245583 0.184992899234571 no 2808 0.168258817529673 4053 17158987
SGTC_2089 5281248 129.67 µM -0.962193941955232 0.184671926726866 no 2809 0.167976095828225 4025 2737878
SGTC_52 0329-0193 875 nM -0.962908879354143 0.184468175763995 no 2810 0.167796626585945 4158 3739292
SGTC_70 0141-0289 43.283 µM -0.965668518058041 0.183683014968614 no 2811 0.167105038765427 4046 352408
SGTC_1197 1601-0112 267 µM -0.965865637223006 0.183627011243348 no 2812 0.167055709531443 4019 7350313
SGTC_2056 5235370 200 µM -0.967528453849309 0.183155010272937 no 2813 0.166639962043164 4010 5511916
SGTC_2536 dehydroabietamide 32.04 µM -0.968333627062405 0.182926728976022 no 2814 0.166438887914102 4143 3983547
SGTC_868 0527-0199 213 µM -0.969788843372527 0.18251459928576 no 2815 0.166075877523564 4004 2849450
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.970375576881935 0.182348595529864 no 2816 0.165929658969491 4116 165506
SGTC_582 0987-0078 156 µM -0.970756706044221 0.182240813707444 no 2817 0.165834723207314 4086 1625765
SGTC_1988 st071872 53.4 µM -0.971833189948658 0.18193660340732 no 2818 0.165566770663101 4089 16414116
SGTC_2877 9040724 71.43 µM -0.974592702002087 0.181158227207623 no 2819 0.164881167567967 4054 6463895
SGTC_1913 st060213 96.1 µM -0.975156032034084 0.180999585328729 no 2820 0.164741434057879 4115 688959
SGTC_693 4161-2696 114 µM -0.975333752381733 0.18094955477901 no 2821 0.164697366608479 4088 805759
SGTC_808 0711-0032 135 µM -0.977504241808647 0.180339233653266 no 2822 0.164159789400648 3975 4252555
SGTC_2478 5763493 32.33 µM -0.980976140661693 0.179365657670152 no 2823 0.163302253784313 4000 1365576 YLR208W SEC13
SGTC_2329 6138490 200 µM -0.982911467909674 0.178824398174723 no 2824 0.162825506591929 4188 720019
SGTC_2799 7812892 81.82 µM -0.984200929925847 0.178464341311056 no 2825 0.162508364334454 4114 20205235
SGTC_2645 abamectin 100 µM -0.985469837611501 0.178110469990748 no 2826 0.162196670060091 4027 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_270 tamoxifen 5.46 µM -0.985826159246678 0.17801117907908 no 2827 0.162109213320117 4110 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3057 9095946 49.47 µM -0.985991993795561 0.17796498030706 no 2828 0.162068520823749 4095 24540043
SGTC_315 k915-0449 187 µM -0.987558741150375 0.177528883526051 no 2829 0.161684400574766 4085 20970215 YNL149C PGA2
SGTC_2683 piperine 63.03 µM -0.987923422474996 0.177427473039713 no 2830 0.161595076670831 4056 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1669 st015249 58.4 µM -0.990392033960546 0.176741964178339 no 2831 0.160991268786144 4150 722793
SGTC_1345 1488-0192 31.4 µM -0.991758959887472 0.176363103692449 no 2832 0.160657560974799 4130 658348
SGTC_3264 9137442 49.47 µM -0.991801203157334 0.176351403636706 no 2833 0.160647255321077 4089 17015726
SGTC_515 4092-1064 102 µM -0.994112221192095 0.175712072852438 no 2834 0.160084118082377 4121 717353
SGTC_1284 0929-0043 16 µM -0.99439313577384 0.175634459553267 no 2835 0.160015754318526 4051 1239883
SGTC_1697 st025554 27.742 µM -0.998064966161812 0.174621975576787 no 2836 0.159123928483231 4063 1269519
SGTC_1750 st081859 2.357 µM -0.998131470097528 0.174603671774568 no 2837 0.159107805874275 4053 5291695
SGTC_878 0828-0289 13.7 µM -1.00197631246259 0.173547531913705 no 2838 0.158177516718653 4039 745350 YLR208W SEC13
SGTC_2340 7987427 183.45 µM -1.00576996788729 0.172509445965058 no 2839 0.157263118507725 4124 2239331
SGTC_316 k060-0003 58.6 µM -1.00597434772309 0.172453632644616 no 2840 0.157213954968768 4118 6152314
SGTC_2185 6113692 200 µM -1.00607410528972 0.172426394409268 no 2841 0.157189961971591 4110 874150
SGTC_757 1066-0008 322 µM -1.0082980732158 0.171819865245236 no 2842 0.156655693860254 4122 6842497
SGTC_2947 9072639 7.68 µM -1.00911196818806 0.171598237629991 no 2843 0.156460469416779 4112 16488146
SGTC_946 3434-1334 87.4 µM -1.00923547544998 0.17156462196193 no 2844 0.156430858425432 4095 4047976
SGTC_3128 9127691 49.47 µM -1.01356979183613 0.170387592105305 no 2845 0.155394039041374 4158 41316314
SGTC_2677 mitomycin C 100 µM -1.014899156984 0.170027627697564 no 2846 0.155076950051641 4134 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_625 k213-0058 121 µM -1.01527967284137 0.169924681719978 no 2847 0.154986265587106 4165 3655420
SGTC_649 1123-0311 367 µM -1.01621397480366 0.169672082230609 no 2848 0.154763751514124 4009 693629 YIL048W NEO1
SGTC_1132 3456-3614 2.5 µM -1.01780895676255 0.169241417019725 no 2849 0.154384377329034 4176 3125502
SGTC_1061 3448-9325 110 µM -1.01798810948026 0.169193087407733 no 2850 0.154341803429918 4019 723482
SGTC_203 k066-0004 30.888 µM -1.01817448401709 0.169142818987521 no 2851 0.154297521575276 4195 6795412
SGTC_2549 cedrol 20.94 µM -1.02395226722968 0.167589209676983 no 2852 0.152928910517169 4074 6708665 A sedative which affects the nervous system.
SGTC_1241 0364-0022 50.8 µM -1.02454290850993 0.167430909465101 no 2853 0.152789457357875 4137 4563895
SGTC_1371 2421-0008 32.7 µM -1.02511561063678 0.167277509231659 no 2854 0.152654320274592 4083 2827552
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.02515109167047 0.167268008495698 no 2855 0.152645950637174 4254 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2275 7947463 200 µM -1.0253532782175 0.16721387575854 no 2856 0.152598262569315 4103 1225414
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.02936657998972 0.166141705338102 no 2857 0.151653723682303 4154 4174840
SGTC_2288 7946289 167.31 µM -1.03075412925439 0.165772051192558 no 2858 0.151328067015959 4191 1246052
SGTC_701 4424-0219 185 µM -1.03260770526355 0.165279074055424 no 2859 0.150893760410575 4176 2911779
SGTC_1310 1188-0297 994 nM -1.03342124880362 0.165063003872808 no 2860 0.150703403371669 4004 1588352
SGTC_3062 9077494 49.47 µM -1.0345586699416 0.164761221293374 no 2861 0.150437531988042 4102 16459633
SGTC_1138 3761-0006 1.03 µM -1.03525637287696 0.164576282500038 no 2862 0.150274599147051 4150 12061087
SGTC_2585 alliin 100 µM -1.03598355625914 0.164383672608538 no 2863 0.15010490701561 4198 87310 A garlic compound which reacts with lipids.
SGTC_3038 9091290 49.47 µM -1.03737183202256 0.164016364404437 no 2864 0.149781300295988 4159 25236843
SGTC_2724 maprotiline 69.64 µM -1.03739649538771 0.164009843820648 no 2865 0.149775555482386 4051 4011 A tricyclic antidepressant.
SGTC_2864 9034755 47.6 µM -1.03982999978348 0.163367292715716 no 2866 0.149209444363069 4074 4930451
SGTC_2796 7949634 45.45 µM -1.04054936319039 0.163177663032315 no 2867 0.149042371362564 4097 2971588
SGTC_1569 carminic acid 40.6 µM -1.04192116755998 0.162816441570395 no 2868 0.148724114676895 4224 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1437 4092-1038 11.6 µM -1.04198950413761 0.162798460893287 no 2869 0.14870827257342 4164 3977136
SGTC_210 3551-0445 56.827 µM -1.04666550819737 0.161571181318033 no 2870 0.147626938544226 4187 2865180 YOR207C RET1
SGTC_2281 7943571 200 µM -1.04698323755245 0.161488008427484 no 2871 0.147553654656708 4258 1244024
SGTC_592 k241-0073 46.5 µM -1.0531984361294 0.159866654145577 no 2872 0.146125027539878 4172 4230158
SGTC_987 1497-1013 404 µM -1.05400188320202 0.159657839414683 no 2873 0.145941027470714 4139 1676435
SGTC_231 b-estradiol 524 µM -1.05731942719916 0.158797505451507 no 2874 0.145182914935435 4137 450 A steroid.
SGTC_741 4582-0002 126 µM -1.05878335377716 0.15841883559733 no 2875 0.144849228196117 4142 2912688
SGTC_1291 0993-0025 5.79 µM -1.05987640953547 0.158136484446901 no 2876 0.14460041458295 4163 4353356
SGTC_2787 5284540 71.43 µM -1.06007191247622 0.158086018224582 no 2877 0.144555942382832 4203 736958
SGTC_2941 9056145 11.23 µM -1.062885866112 0.157360808561649 no 2878 0.143916856687636 4076 2119517
SGTC_51 1013-0126 23.419 µM -1.06335322472373 0.157240573413741 no 2879 0.143810898267718 4147 1627850
SGTC_1514 1189-1591 158 µM -1.06398216226604 0.157078864978625 no 2880 0.143668390153093 4178 767698 YMR146C TIF34
SGTC_909 3448-9333 149 µM -1.06461368402592 0.15691660219842 no 2881 0.143525392412077 4082 3344074
SGTC_2568 diosmetin 100 µM -1.06738083648069 0.156206912581587 no 2882 0.142899949219458 4215 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1285 0929-0069 65.5 µM -1.0697738589451 0.155594883574928 no 2883 0.142360555804773 4193 1206237
SGTC_2299 7976368 114.88 µM -1.07792439269764 0.153522221809227 no 2884 0.140533749352351 4202 2979718
SGTC_397 arbidol 50 µM -1.07804879031577 0.153490730110662 no 2885 0.140505991550336 4215 131410 A RNA synthesis inhibitor.
SGTC_620 0109-0052 432 µM -1.07952807672002 0.153116571466609 no 2886 0.140176192236104 4169 493037
SGTC_127 0180-0333 59.125 µM -1.0808196330305 0.152790390456586 no 2887 0.139888676695678 4063 771601
SGTC_594 1487-1584 10.8 µM -1.08317130486679 0.152197662812385 no 2888 0.139366196968924 4131 5013332
SGTC_2018 5133068 143 µM -1.08494865374909 0.151750704827923 no 2889 0.138972198662228 4134 785362
SGTC_2685 mycophenolic acid 18.85 µM -1.08599640755297 0.151487630497642 no 2890 0.13874029081446 4159 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3042 9091578 49.47 µM -1.08621431611505 0.151432955233226 no 2891 0.138692092474804 4149 25236497
SGTC_1051 3253-3903 78 µM -1.08767657529796 0.151066400434015 no 2892 0.138368956184292 4162 5509239
SGTC_1682 st012968 530 nM -1.08874455493107 0.150799055844023 no 2893 0.138133273979486 4201 24207270
SGTC_2742 clothiapine 36.27 µM -1.0898520950103 0.150522141088967 no 2894 0.137889150845343 4181 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2407 paclitaxel 400 µM -1.09076242770217 0.15029478725283 no 2895 0.137688716519861 4290 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1027 k015-0025 8.67 µM -1.09081832533333 0.150280834388377 no 2896 0.137676415629499 4148 3598955
SGTC_1111 tnp00062 510.699 nM -1.09087286338114 0.150267221727791 no 2897 0.137664414653322 4228 676306
SGTC_1664 st014217 9.02 µM -1.09143907120129 0.150125945183364 no 2898 0.13753986406303 4238 3982782
SGTC_2591 skatole 100 µM -1.09228038027453 0.149916190711714 no 2899 0.137354940652653 4206 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1003 4049-0218 100 µM -1.09466859353419 0.149321828688012 no 2900 0.136830926306666 4217 295161
SGTC_1 0258-0098 57.368 µM -1.09599498136092 0.148992406886632 no 2901 0.136540485373976 4130 6790032 YDR047W HEM12
SGTC_2676 harmalol 100 µM -1.09798259068357 0.148499673594585 no 2902 0.136106045675192 4141 5459187 A monoamine oxidase inhibitor
SGTC_1115 galangin 695.678 nM -1.09986377103166 0.14803432910654 no 2903 0.135695740947366 4260 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2075 5212009 200 µM -1.10860859356652 0.145883960609132 no 2904 0.13379953464447 4117 780898
SGTC_2989 9073649 71.4286 µM -1.10953405477586 0.145657622528733 no 2905 0.133599930906322 4153 21367202
SGTC_3093 9117344 49.47 µM -1.10971473387577 0.145613461785958 no 2906 0.133560985888657 4235 24824913
SGTC_341 1486-1430 230 µM -1.10985332917218 0.145579593071976 no 2907 0.133531117242149 4155 2054753 YPL210C SRP72
SGTC_3213 9129884 49.47 µM -1.11001636477721 0.145539758628878 no 2908 0.133495987349955 4200 17190742
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.11003808743013 0.145534451692675 no 2909 0.133491307168533 4182 6312947
SGTC_2350 9023895 38.85 µM -1.1106493356938 0.145385174499059 no 2910 0.133359658984534 4218 2997209
SGTC_189 3970-0742 2.116 µM -1.11216269619453 0.145016029505648 no 2911 0.133034101914276 4138 2891807
SGTC_346 4513-0042 7.16 µM -1.11386729749031 0.144600992463033 no 2912 0.13266806037496 4178 2827372
SGTC_852 0418-0143 439 µM -1.11431003129536 0.144493326487406 no 2913 0.132573102498212 4206 5369229
SGTC_1740 st038286 13.222 µM -1.11737743876038 0.143748864432535 no 2914 0.131916488744138 4255 716786
SGTC_1587 estradiol valerate 56.1 µM -1.1192676036458 0.14329141102391 no 2915 0.131512996115656 4262 13791 A steroid.
SGTC_2111 5486399 200 µM -1.12152848128612 0.142745531124933 no 2916 0.131031487565846 4174 689674
SGTC_2556 citropten 84.59 µM -1.12282863705058 0.14243225119732 no 2917 0.130755140245727 4247 2775 A potential DNA crosslinker.
SGTC_82 0054-0107 293.755 µM -1.12568288336681 0.141746136526381 no 2918 0.130149885674061 4170 3104697
SGTC_418 lividomycin a 100 µM -1.12920457005955 0.140902669617756 no 2919 0.129405773156744 4247 72394 An antibiotic.
SGTC_2234 tolnaftate 200 µM -1.13175685211595 0.140293513577916 no 2920 0.128868336241998 4285 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1797 st048695 56.8 µM -1.13220359491299 0.140187073175875 no 2921 0.128774424550664 4197 592262 YIL048W NEO1
SGTC_1227 3909-8010 46.6 µM -1.13245785361805 0.140126518303316 no 2922 0.128720996959258 4203 15982272
SGTC_1717 st033143 58.0435 µM -1.13292678633814 0.14001488275934 no 2923 0.128622500083674 4288 674616
SGTC_68 0986-0284 82.829 µM -1.13459454195315 0.139618341558779 no 2924 0.128272620539239 4272 423278 YIL048W NEO1
SGTC_1881 5652484 16 µM -1.13465919948968 0.139602983370041 no 2925 0.128259069312577 4212 2255129
SGTC_1421 4029-0249 71.4 µM -1.1355581422056 0.139389575356514 no 2926 0.128070767710854 4312 2894095
SGTC_2761 levamisole 97.89 µM -1.13583518852713 0.139323849626284 no 2927 0.128012773526961 4251 26879 An alkaline phosphatase inhibitor.
SGTC_1879 gemcitabine 100 µM -1.13599844607539 0.139285128716334 no 2928 0.12797860732312 4204 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1578 josamycin 24.2 µM -1.13650857996779 0.139164183960182 no 2929 0.127871888380684 4227 5282165 A P450 substrate.
SGTC_3139 9095020 49.47 µM -1.13793058318783 0.138827426653973 no 2930 0.127574734780355 4018 25236292
SGTC_1660 st012960 28.1 µM -1.13921359869555 0.138524060886718 no 2931 0.127307037514874 4254 24207266
SGTC_2982 9019404 25.97 µM -1.14015344142511 0.138302124293406 no 2932 0.127111190314133 4177 22333232
SGTC_2412 st077135 33.4 µM -1.14040199099018 0.138243471784601 no 2933 0.127059431894602 4301 13258915
SGTC_1520 flindersine 88 µM -1.14091241501108 0.138123075547661 no 2934 0.126953186247712 4301 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_373 0844-0104 25.9 µM -1.1409897124988 0.138104849242745 no 2935 0.126937102034316 4251 5375804
SGTC_2172 5754775 163.918 µM -1.1410564296099 0.13808911904881 no 2936 0.126923220547055 4209 2263357
SGTC_2974 9094440 9.66 µM -1.14712564803617 0.136663261487618 no 2937 0.125664847536502 4244 25236134
SGTC_1305 1181-0477 144 µM -1.14837246699821 0.136371593941062 no 2938 0.125407417419195 4295 6252086
SGTC_988 1497-1057 103 µM -1.14839120622249 0.136367213537301 no 2939 0.125403551150318 4221 3533044
SGTC_1034 k072-0165 12.7 µM -1.14951277847893 0.136105214713577 no 2940 0.125172300330051 4266 5835461
SGTC_2019 4016004 108 µM -1.14970932897227 0.136059336101802 no 2941 0.125131805349001 4276 45595336
SGTC_3201 9113999 49.47 µM -1.15248062056387 0.135413590900775 no 2942 0.124561814378545 4249 16649224
SGTC_1333 1482-0047 286 µM -1.15261074425558 0.135383322184871 no 2943 0.12453509561255 4256 3811116
SGTC_2273 7815444 169.05 µM -1.15448790397331 0.134947182714129 no 2944 0.124150097428026 4208 2824616
SGTC_2777 climbazole 1.536 µM -1.15614280690408 0.134563482572957 no 2945 0.123811374533197 4104 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_790 1575-0012 79.1 µM -1.15677934630623 0.134416096332877 no 2946 0.123681261093614 4305 378741 YLR208W SEC13
SGTC_2236 dapsone 200 µM -1.15770655203735 0.134201606718338 no 2947 0.123491904622277 4230 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3260 9137109 49.47 µM -1.15814585599676 0.134100065077158 no 2948 0.123402259706504 4197 17478346
SGTC_3123 9126162 49.47 µM -1.15934715476866 0.133822663916642 no 2949 0.123157353987533 4306 25239884
SGTC_993 3909-8757 62.7 µM -1.1596778099804 0.133746379045998 no 2950 0.123090003977888 4195 4288324 YLR208W SEC13
SGTC_1516 st013856 110 µM -1.16001027958971 0.133669705725184 no 2951 0.123022310433472 4299 5281404 A mutagen and neurotoxin.
SGTC_1394 3474-0001 65.7 µM -1.16021508913609 0.133622488098591 no 2952 0.122980622519565 4232 5017666 YIL048W NEO1
SGTC_299 1273-0059 1.44 µM -1.16227049906318 0.133149260599057 no 2953 0.122562802944953 4070 2848077
SGTC_3136 9095672 49.47 µM -1.16302755803226 0.132975250055828 no 2954 0.122409160788028 4015 17217380
SGTC_941 3237-0776 460 µM -1.16380713619388 0.132796227137691 no 2955 0.122251089761197 4289 760008
SGTC_222 nsc-310342 10.666 µM -1.16478339264212 0.13257227303432 no 2956 0.122053341452123 4270 432556
SGTC_815 1582-0027 36.9 µM -1.1652385848376 0.13246794053329 no 2957 0.12196121557188 4293 3128206
SGTC_1389 3405-0187 19 µM -1.16532423495729 0.132448315391174 no 2958 0.121943886393246 4224 799890
SGTC_3154 9100113 49.47 µM -1.16746668576971 0.131958064165582 no 2959 0.12151097717736 4265 25237525
SGTC_2959 9079155 11 µM -1.16782841911245 0.131875413361974 no 2960 0.121437991123234 4289 16189457
SGTC_1225 1216-0074 20.6 µM -1.16926274259684 0.131548042885658 no 2961 0.121148894581019 4273 4241466
SGTC_3302 9125395 16.351 µM -1.17217798097469 0.130884397673405 no 2962 0.120562803393839 4205 17599668
SGTC_1472 k841-0093 193 µM -1.17310525916942 0.130673791452301 no 2963 0.12037679888427 4375 X1472
SGTC_1802 st050112 57.9 µM -1.1733840680583 0.130610513374025 no 2964 0.120320911620836 4259 4662563
SGTC_1067 clotrimazole 1.36 µM -1.17364934181261 0.130550326882879 no 2965 0.120267754447087 4294 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1360 1598-0022 39.8 µM -1.17442139623054 0.130375268881402 no 2966 0.120113139627462 4295 761525
SGTC_2415 st077333 57.7 µM -1.17549350552028 0.130132444912931 no 2967 0.119898666968724 4308 2766255
SGTC_2892 9047358 58.44 µM -1.17694066501396 0.129805171773843 no 2968 0.11960959487141 4272 6466771
SGTC_792 4534-1957 155 µM -1.17930102307488 0.129272603738378 no 2969 0.119139165514747 4224 1717904
SGTC_113 0099-0221 2.5 µM -1.17939239115319 0.129252018833125 no 2970 0.119120981765368 4233 89219
SGTC_2850 9015429 58.44 µM -1.18043789204484 0.129016632915041 no 2971 0.118913049373933 4281 6457570
SGTC_152 4469-0003 551.229 µM -1.18124345606317 0.128835469683409 no 2972 0.118753011291091 4253 697280
SGTC_1470 k295-0292 231 µM -1.18161921361012 0.128751025977421 no 2973 0.118678413150405 4340 5045612
SGTC_1488 4013-0813 75.9 µM -1.18195270422708 0.128676113055798 no 2974 0.118612233887003 4203 2910057
SGTC_2611 pyromycin 23.93 µM -1.18380277681619 0.128261075433349 no 2975 0.118245571387935 4235 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2870 9038528 12.99 µM -1.18465090007994 0.128071122057223 no 2976 0.118077751575325 4309 6463316
SGTC_977 1348-1378 135 µM -1.1867630820644 0.127598908247656 no 2977 0.117660542358114 4266 X977
SGTC_293 4049-0273 38.5 µM -1.18725253104199 0.127489656666807 no 2978 0.117564012928953 4148 1380311
SGTC_1368 1852-0141 284 µM -1.18881531033519 0.127141258841326 no 2979 0.117256175959278 4275 2838987
SGTC_1868 st057644 42.7 µM -1.19028931355007 0.126813259894627 no 2980 0.116966349766879 4302 688665
SGTC_2621 lithochol-11-enic acid 100 µM -1.19177054106115 0.126484247312532 no 2981 0.116675614887765 4241 6708711
SGTC_2076 5212012 200 µM -1.19349518191536 0.126101917227988 no 2982 0.116337748993127 4237 604802
SGTC_1139 k015-0024 46.9 µM -1.19402646885704 0.125984300425558 no 2983 0.116233807177987 4295 2766652
SGTC_2935 9038016 29.96 µM -1.19433469534976 0.125916100027301 no 2984 0.116173535475435 4260 6463195
SGTC_2782 7736369 71.43 µM -1.19580070829994 0.125592071984942 no 2985 0.115887169732504 4292 2950836 YOL077C BRX1
SGTC_2045 5106652 78.05 µM -1.19678285781328 0.125375316433207 no 2986 0.115695600739658 4257 673349
SGTC_1412 3909-8563 178 µM -1.19702514272565 0.125321885527484 no 2987 0.115648377495497 4363 23767530
SGTC_804 1595-0054 20.9 µM -1.19717383553795 0.125289102288378 no 2988 0.115619402872172 4235 761523 Stimulates phospholipase C.
SGTC_3015 9080845 49.47 µM -1.19962252117494 0.124750086213005 no 2989 0.115142987948125 4321 5296973
SGTC_2713 st079149 53.4 µM -1.20524417864467 0.1235187577483 no 2990 0.114054526028017 4315 3103253
SGTC_2883 9059145 45.46 µM -1.20578409200847 0.123400948508967 no 2991 0.113950375420963 4280 16476510
SGTC_595 3909-8003 73.7 µM -1.20689355318786 0.123159110908756 no 2992 0.11373657038237 4359 699517
SGTC_1819 st053448 58.6 µM -1.20773915892898 0.122975011065627 no 2993 0.113573805240794 4198 2857616
SGTC_2306 7482397 179.52 µM -1.21366429280159 0.121690440774312 no 2994 0.112437972476472 4312 891448
SGTC_317 4495-0002 170 µM -1.21468601952631 0.121469886866679 no 2995 0.112242933352369 4319 15991618
SGTC_1559 coumarin 343 70.1 µM -1.21679451974749 0.121015626498577 no 2996 0.111841202825842 4319 108770 A hepatotoxic, DNA x-linker.
SGTC_486 niguldipine 82 µM -1.21693623605357 0.120985137719093 no 2997 0.111814238681181 4372 1236 A calcium channel blocker.
SGTC_747 3448-8087 38.7 µM -1.22030606820373 0.120261745374597 no 2998 0.11117443514461 4368 5168703
SGTC_3355 9151058 44.0485 µM -1.22392381688205 0.119488531171999 no 2999 0.110490484013828 4322 17015728
SGTC_423 5-fluorouracil 457 µM -1.22519580929988 0.119217505939549 no 3000 0.110250726533067 4237 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_190 3970-0790 3.722 µM -1.22644935939699 0.118950835041366 no 3001 0.110014810516865 4270 2832352
SGTC_1216 1165-0504 9.65 µM -1.22674925098753 0.118887100830353 no 3002 0.109958425154888 4314 6304004
SGTC_1376 2910-0861 41.3 µM -1.22710744423847 0.118811007719049 no 3003 0.109891105143919 4243 1112859
SGTC_1804 st050076 49.1 µM -1.23081524298435 0.118025358804952 no 3004 0.109195986586906 4325 3895976
SGTC_708 3448-5400 146 µM -1.23268543493527 0.117630479348375 no 3005 0.108846573991564 4271 3462195
SGTC_1451 4152-0210 104 µM -1.23345535931948 0.117468186627593 no 3006 0.108702960947984 4351 659563
SGTC_949 1165-0505 146 µM -1.23986058230673 0.116124170717198 no 3007 0.107513482832446 4294 6244267
SGTC_117 lucigenin 22.078 µM -1.24020316597824 0.116052594710554 no 3008 0.107450128843647 4308 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_390 dec-rvkr-cmk 16.7 µM -1.24118306434864 0.115848037455731 no 3009 0.107269064827705 4365 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1575 cyproterone acetate 48 µM -1.24142494568349 0.115797583294747 no 3010 0.107224404262337 4337 9880 An androgen receptor antagonist and liver toxin.
SGTC_1767 st044992 70.3 µM -1.24217742260388 0.115640723510647 no 3011 0.107085553915082 4369 9600693
SGTC_1352 1496-0991 99 µM -1.24490974757203 0.115072417978667 no 3012 0.106582463716538 4317 3000039
SGTC_848 0368-0089 85.6 µM -1.24619681513572 0.114805405627289 no 3013 0.106346074015261 4318 762535
SGTC_2875 9039966 71.43 µM -1.24839512291486 0.114350369197171 no 3014 0.10594319709215 4332 6463691
SGTC_162 k030-0015 37.8 µM -1.25032648353823 0.113951650161619 no 3015 0.105590153914633 4393 1809920 YMR134W ERG29
SGTC_2575 plumbagin 510 nM -1.25114389236008 0.113783199177017 no 3016 0.105440992119384 4232 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3279 9140807 49.47 µM -1.25433305148854 0.113127676891284 no 3017 0.104860487688784 4371 45595718
SGTC_1198 1612-1005 86.7 µM -1.25454144856216 0.11308493547734 no 3018 0.104822635063853 4399 6998509
SGTC_3307 9126885 69.2785 µM -1.25485400731574 0.113020852520193 no 3019 0.104765881370359 4298 24824909
SGTC_1734 st037168 69.4 µM -1.25521243646685 0.112947396803403 no 3020 0.104700826030478 4335 708907
SGTC_732 3970-1727 52.7 µM -1.25641906796557 0.112700362749865 no 3021 0.10448203594178 4411 1275699
SGTC_2801 7907800 81.82 µM -1.26076483415995 0.111813850365934 no 3022 0.103696793558817 4343 6620925
SGTC_3341 9147222 25.867 µM -1.2608038713468 0.11180590966117 no 3023 0.103689759333434 4336 1939759
SGTC_837 0091-0265 12.5 µM -1.26467970607859 0.111019518102184 no 3024 0.102993083816682 4329 759367
SGTC_2342 7990637 118.86 µM -1.26799151268126 0.110350710866185 no 3025 0.102400490755633 4356 2033102 YER133W GLC7
SGTC_2198 6589944 200 µM -1.27026326636006 0.109893612237119 no 3026 0.101995434163649 4339 5290268
SGTC_525 k781-2675 26.7 µM -1.27249779400191 0.109445330990492 no 3027 0.101598153692554 4300 3651118 YDL195W SEC31
SGTC_1591 genipin 88.4 µM -1.27331170876697 0.109282373701275 no 3028 0.101453726737244 4374 442424 A DNA cross-linking agent.
SGTC_1482 3346-2049 8.48 µM -1.27583994239163 0.108777297320832 no 3029 0.101006052404884 4372 3826804
SGTC_421 streptovitacin 30 mM -1.27599621646754 0.108746132934095 no 3030 0.100978428283416 4370 91467 include heat shock
SGTC_1103 duloxetine 36.1 µM -1.27682192878024 0.108581574856489 no 3031 0.100832560904183 4429 60835 A selective serotonin reuptake inhibitor.
SGTC_2430 5571206 200 µM -1.27783656952132 0.108379610185297 no 3032 0.100653528580698 4342 1731771
SGTC_1331 1472-0049 76.2 µM -1.27934011186717 0.10808082673247 no 3033 0.100388656599091 4316 24051409
SGTC_2366 9070441 60.58 µM -1.28058622130826 0.107833650036043 no 3034 0.100169521115818 4319 6837235
SGTC_1205 4161-2785 76 µM -1.28136848766095 0.107678688843686 no 3035 0.100032133632524 4371 3498106
SGTC_2383 9036125 200 µM -1.28257170638948 0.107440653362363 no 3036 0.099821083994006 4279 79580
SGTC_2994 9053520 71.4286 µM -1.28334885636429 0.107287109757579 no 3037 0.0996849416084368 4391 4647384
SGTC_849 0386-0493 241 µM -1.28359534610586 0.107238443179547 no 3038 0.0996417894892955 4347 726119
SGTC_95 0471-0001 561.058 µM -1.2846373992284 0.10703287760102 no 3039 0.0994595116214449 4343 4015405
SGTC_460 trequinsin 123 µM -1.28465765020137 0.107028885513613 no 3040 0.0994559716995048 4436 5537 A vasodilator.
SGTC_338 4055-0136 114 µM -1.28581491930855 0.106800930707018 no 3041 0.0992538310701773 4343 2900563
SGTC_228 caffeine 993.056 µM -1.28730483545592 0.106507968385519 no 3042 0.0989940294114686 4349 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1140 3229-1848 2.98 µM -1.28826043455993 0.106320374506461 no 3043 0.0988276604615109 4361 2849525
SGTC_1608 st001473 40.5 µM -1.28856211080235 0.106261201959334 no 3044 0.0987751814104337 4303 7292267
SGTC_1122 capsaicin 818.572 nM -1.28860093495167 0.1062535884909 no 3045 0.0987684291133575 4402 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1653 st012112 65 µM -1.29000526523476 0.105978462235589 no 3046 0.0985244149962672 4343 720429
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.29004710695641 0.105970272812344 no 3047 0.0985171514247403 4359 616764
SGTC_2663 amphotericin b 100 µM -1.2903267775242 0.105915546352838 no 3048 0.0984686116935248 4379 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2182 6325192 200 µM -1.29186874286185 0.105614178431198 no 3049 0.098201301997956 4367 736248
SGTC_1755 st041960 45.185 µM -1.29478722121856 0.105045477594139 no 3050 0.0976968207247003 4376 2257073
SGTC_883 0850-0245 24.6 µM -1.29531737507693 0.104942409032729 no 3051 0.0976053838801488 4433 6823229 YPR165W RHO1
SGTC_5 0352-0601 109.883 µM -1.295856077715 0.104837753492792 no 3052 0.0975125369041142 4260 762456
SGTC_648 0375-0473 33.3 µM -1.29720813556937 0.104575417654464 no 3053 0.0972797911172914 4335 1713139
SGTC_737 1950-0117 57.9 µM -1.30000216867433 0.104034806956692 no 3054 0.0968001129434685 4356 5393513
SGTC_935 2996-0153 430 µM -1.30222530554816 0.103606107440936 no 3055 0.0964196884890088 4375 23738523
SGTC_1177 0983-0204 23.6 µM -1.30292807968065 0.103470854733512 no 3056 0.0962996582130828 4392 766818
SGTC_1903 st060211 78.3 µM -1.30467646567102 0.103134924436819 no 3057 0.0960015192422278 4385 688960
SGTC_1821 st053465 65.6 µM -1.30512008022642 0.103049815619822 no 3058 0.0959259810951378 4377 675086
SGTC_180 1486-1293 102.781 µM -1.31161982287446 0.101808664711259 no 3059 0.0948242206135677 4320 4140536
SGTC_2318 6029776 164 µM -1.31252451990776 0.101636775710337 no 3060 0.0946716091988282 4414 818325
SGTC_1799 st045822 46.1415 µM -1.31338130264224 0.101474185159452 no 3061 0.0945272473216587 4365 3674992
SGTC_723 4182-0001 115 µM -1.31339877369938 0.101470871671603 no 3062 0.0945243052605149 4392 744821 YLR208W SEC13
SGTC_913 3487-1245 167 µM -1.31644884607137 0.100893614830646 no 3063 0.0940117184749728 4330 4016153
SGTC_2852 9023854 51.95 µM -1.31865720302399 0.100477157982053 no 3064 0.0936418702614494 4410 19798528
SGTC_133 0724-0033 378.92 µM -1.32002801914956 0.100219278152153 no 3065 0.0934128316460299 4209 280309
SGTC_2911 7942208 15.64 µM -1.32223839251807 0.0998044777832708 no 3066 0.0930443901745121 4397 1243384
SGTC_1904 st060225 78 µM -1.3238505269705 0.0995027352685511 no 3067 0.09277634579724 4342 66595
SGTC_954 1189-0853 2.85 µM -1.32601302045815 0.0990990300700436 no 3068 0.0924176922981516 4306 2828194
SGTC_3170 9103054 49.47 µM -1.3262333807609 0.0990579594498341 no 3069 0.0923812028165685 4363 16432970
SGTC_1689 st020265 53.493 µM -1.32907870465513 0.0985287675265349 no 3070 0.0919110025857004 4389 5758320 YPR016C TIF6
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.33222744708218 0.0979455597485436 no 3071 0.091392729962415 4381 75037 A free radical scavenger.
SGTC_3271 9137798 49.47 µM -1.33276422309864 0.0978463914103917 no 3072 0.0913045949556375 4369 6498326
SGTC_1969 st069479 40.1 µM -1.33502729899389 0.0974291016821813 no 3073 0.0909337059413681 4392 3895485
SGTC_691 1548-0686 185 µM -1.33516867661423 0.0974030763790107 no 3074 0.0909105731160586 4362 46495133
SGTC_328 k915-0120 63.5 µM -1.33637465668373 0.0971812824687709 no 3075 0.0907134228139627 4401 6624543
SGTC_1073 triclabendazole 3.09 µM -1.34532486337388 0.0955468062530289 no 3076 0.089260173847646 4425 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2481 5478948 45.16 µM -1.34549017108925 0.0955168094068277 no 3077 0.0892334966427195 4397 77792
SGTC_2388 9080168 200 µM -1.34837081932445 0.0949951973411605 no 3078 0.0887695722935602 4424 15943073
SGTC_570 0987-0065 62.6 µM -1.34958344919946 0.0947762496166756 no 3079 0.0885748180268578 4239 3104428
SGTC_787 4152-0075 138 µM -1.35029141373233 0.0946485943550203 no 3080 0.0884612627263784 4413 9566539
SGTC_2272 7805186 180 µM -1.35151143517239 0.0944289059955662 no 3081 0.0882658296696321 4417 2956062 YPR165W RHO1
SGTC_1692 fluoroquinolonic acid 71 µM -1.3521273177439 0.0943181473929897 no 3082 0.0881672948503186 4412 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_897 1000-0139 31.4 µM -1.3553154245225 0.0937463385295066 no 3083 0.0876585413701709 4371 6151020
SGTC_1553 gossypol 38.6 µM -1.35558390802719 0.0936983012576536 no 3084 0.0876157973610756 4311 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_860 0443-0016 25.1 µM -1.35887001869423 0.0931118196296565 no 3085 0.0870938904153958 4424 5337942
SGTC_597 k018-0003 82.8 µM -1.3598234312499 0.0929421701805072 no 3086 0.0869429028550495 4471 6786234
SGTC_2580 diallyl disulphide 81.36 µM -1.36229787807741 0.0925029354674312 no 3087 0.0865519485143634 4400 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_119 0121-0043 24.815 µM -1.36255727150642 0.0924569800786692 no 3088 0.0865110414422252 4425 1092378
SGTC_364 0083-0097 67.7 µM -1.36280984388675 0.0924122493738416 no 3089 0.0864712239590236 4431 5207356
SGTC_294 k038-0071 157 µM -1.36309146912405 0.0923623922768423 no 3090 0.0864268425145437 4413 24152826
SGTC_2224 6650123 117.647 µM -1.36340941072647 0.092306129891583 no 3091 0.0863767584284319 4430 2908370
SGTC_1358 1509-0022 2.48 µM -1.36493122870475 0.0920371828958526 no 3092 0.0861373329636196 4439 3258434
SGTC_1388 3346-4487 254 µM -1.36716946683595 0.0916426796861086 no 3093 0.08578609668409 4480 3345614
SGTC_2963 9082507 9 µM -1.36867608397202 0.091377835602507 no 3094 0.0855502746804038 4429 16459611
SGTC_1303 1160-0052 261 µM -1.37072237757723 0.0910190324903529 no 3095 0.085230758132205 4356 3562476
SGTC_260 nsc-65238 3.989 µM -1.3736847236442 0.090501459079073 no 3096 0.0847697907338635 4403 3246252
SGTC_2300 7976697 71.57 µM -1.37583566934784 0.0901270229568304 no 3097 0.084436257762212 4312 2236109
SGTC_1640 st009078 66.4 µM -1.37591246212524 0.0901136761982097 no 3098 0.0844243682422566 4388 690618
SGTC_2232 chlorophetanol 41.5365 µM -1.37731192591597 0.0898707033737697 no 3099 0.0842079148146998 4492 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_470 aa-861 153 µM -1.37752070078647 0.0898344979680951 no 3100 0.0841756595874609 4381 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3317 9138495 8.753 µM -1.37836425357197 0.0896883207815285 no 3101 0.0840454270975158 4334 17020139
SGTC_405 ebelactone b 50 µM -1.3797987006569 0.0894401551315292 no 3102 0.083824316408561 4356 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_621 3584-0052 32.1 µM -1.384324053674 0.0886605965600716 no 3103 0.083129626003373 4447 2273927
SGTC_3282 9108498 15.4605 µM -1.38517260470315 0.0885149863100102 no 3104 0.0829998476852046 4386 16459645
SGTC_3203 9113543 49.47 µM -1.38819385411328 0.087997990192859 no 3105 0.082539011623506 4458 17018012
SGTC_3107 9121808 49.47 µM -1.38965250874944 0.0877491926948421 no 3106 0.0823172112952223 4385 662681
SGTC_1974 st069448 26.9 µM -1.39032211636986 0.0876351560131186 no 3107 0.0822155424395068 4417 6323587 YNR016C ACC1
SGTC_831 k061-1017 217 µM -1.39538306824851 0.0867768308819602 no 3108 0.0814501771970804 4461 1240153
SGTC_677 0929-0063 136 µM -1.39547712296889 0.0867609391009836 no 3109 0.0814360043828914 4454 1539583
SGTC_1527 coumarin 137 µM -1.39608873617631 0.0866576520608311 no 3110 0.0813438876547459 4467 323 A hepatotoxic, DNA x-linker.
SGTC_2948 9070189 9.45 µM -1.39799575765557 0.0863361911417081 no 3111 0.081057170570587 4370 6473636 YDL196W YDL196W
SGTC_1605 st000082 49.1 µM -1.40631685012163 0.0849439587771006 no 3112 0.079815029381582 4388 1114022
SGTC_2170 morpholine 200 µM -1.40876063343957 0.0845382948911849 no 3113 0.0794529796024754 4481 121171 Reacts with secondary amines.
SGTC_1307 1187-1599 12.2 µM -1.41003562071614 0.0843272269128386 no 3114 0.0792645825962133 4439 1538471
SGTC_3104 9120930 49.47 µM -1.4132775402119 0.0837923242776756 no 3115 0.0787870675731719 4475 17014836
SGTC_1005 4092-0690 4.4 µM -1.41483382742849 0.0835364508153125 no 3116 0.0785586116938472 4460 1529343
SGTC_2681 menadione 3.18 µM -1.41645015900938 0.0832713273308631 no 3117 0.0783218735022235 4466 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2316 5844804 197.44 µM -1.41685398310754 0.0832051877832699 no 3118 0.0782628114094154 4453 776813
SGTC_2755 lomerizine 42.69 µM -1.42014060730795 0.0826683626185723 no 3119 0.077783375189302 4377 3949 A calcium channel blocker.
SGTC_2134 5324836 1.464 µM -1.42392992137148 0.0820526698531262 no 3120 0.0772333796170941 4430 699272
SGTC_1233 0325-0408 14.2 µM -1.43282405437694 0.0806211184310296 no 3121 0.0759540626292222 4493 12874
SGTC_1146 3579-1023 7 µM -1.4335044110087 0.0805123935044482 no 3122 0.075856869623883 4469 X1146
SGTC_2191 5911152 200 µM -1.43489106589158 0.0802911410151143 no 3123 0.075659070984263 4480 2875902
SGTC_447 ml7 120 µM -1.43521091134804 0.0802401722494632 no 3124 0.0756135026189822 4515 4216 Selective myosin light chain kinase inhibitor.
SGTC_3102 9121669 49.47 µM -1.4357028798645 0.0801618226634083 no 3125 0.075543452711543 4498 41905072
SGTC_1644 st010134 20.9 µM -1.43687992757198 0.0799746039047436 no 3126 0.0753760571456663 4434 3818134
SGTC_809 3998-0021 90 µM -1.4369276448182 0.079967021078062 no 3127 0.0753692769354287 4404 715485
SGTC_2997 9067075 71.4286 µM -1.43900207158524 0.0796378957681244 no 3128 0.0750749679079478 4427 27209819
SGTC_143 4032-1194 15.74 µM -1.44358643915761 0.078914183592185 no 3129 0.0744276708722629 4489 1806963
SGTC_2387 9077560 195.08 µM -1.4441088482248 0.0788320306051176 no 3130 0.0743541797653403 4465 5303272
SGTC_551 k048-0028 34.9 µM -1.4523777660899 0.0775402925383118 no 3131 0.0731982975159096 4436 6836383
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.45438577189844 0.0772290486225524 no 3132 0.0729196911964646 4448 688761
SGTC_2627 acetyl isogambogic acid 100 µM -1.45455531064648 0.0772028133775519 no 3133 0.0728962052858479 4480 6857789 A caspase activator and apoptosis inducer.
SGTC_736 0958-0254 92.6 µM -1.45589467764603 0.0769957912570544 no 3134 0.0727108686079777 4523 6812352
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.4615453860777 0.0761270204226837 no 3135 0.0719329148354385 4457 5379071
SGTC_256 clotrimazole 625 nM -1.46277948218475 0.0759382803445707 no 3136 0.071763864564632 4408 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1283 0922-0125 16.4 µM -1.46284579047026 0.0759281493898933 no 3137 0.0717547900860501 4469 3360884
SGTC_2394 5221648 200 µM -1.46346116198946 0.0758341785411628 no 3138 0.0716706167144909 4496 788586
SGTC_37 0566-0070 1.56 µM -1.46574519970369 0.0754861669339048 no 3139 0.0713588576812601 4397 1626686
SGTC_3165 9101544 49.47 µM -1.46619037650209 0.0754184787002101 no 3140 0.0712982148032102 4470 5002184
SGTC_1154 4088-0362 150 µM -1.46627885583979 0.0754050311078822 no 3141 0.0712861666842518 4483 6618304
SGTC_1947 st076332 61.6 µM -1.46666838619378 0.0753458498045046 no 3142 0.0712331434167625 4352 24208416
SGTC_1475 4092-1048 11.7 µM -1.46687989409389 0.0753137302675112 no 3143 0.0712043654333378 4482 2881759
SGTC_2320 7373003 200 µM -1.46747054057903 0.0752240901108947 no 3144 0.0711240487309703 4468 5415828
SGTC_1719 st032227 49.2 µM -1.4690738061552 0.0749811787050333 no 3145 0.0709063857698759 4469 3125804
SGTC_2973 9094665 17.96 µM -1.47112478281716 0.0746713071996915 no 3146 0.0706286869675014 4466 25237061 YIL048W NEO1
SGTC_451 chloral hydrate 100 µM -1.47410044941733 0.0742234678334802 no 3147 0.0702272737760113 4468 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_958 1222-0007 33 µM -1.48028012618969 0.073299980476916 no 3148 0.0693992523578456 4523 7312461
SGTC_3340 9146634 11.102 µM -1.48087258313481 0.073211907837053 no 3149 0.0693202651023083 4474 4907387
SGTC_3067 9117431 49.47 µM -1.48530023571701 0.0725562695591029 no 3150 0.0687321547353691 4489 17150885
SGTC_1546 5-methoxyflavanone 78.7 µM -1.50168990779899 0.0701684069281829 no 3151 0.0665886057496996 4520 147795
SGTC_2480 5767542 37.17 µM -1.50195845360911 0.0701297911528776 no 3152 0.0665539194408976 4421 2867358
SGTC_2952 9073731 13.78 µM -1.50555639397475 0.0696139976168429 no 3153 0.0660905448436163 4496 16457353
SGTC_1302 1159-0335 255 µM -1.51163376442846 0.0687493978787914 no 3154 0.0653135285935536 4517 649284
SGTC_2470 5664817 21.68 µM -1.51176364866991 0.0687310106263962 no 3155 0.0652970000535918 4551 2859561
SGTC_1077 5-fluorocytosine 377 nM -1.52172723738885 0.0673317721163512 no 3156 0.0640387199434615 4543 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2842 9000675 19.48 µM -1.52794558403152 0.0664697215984822 no 3157 0.0632630245573959 4498 2989072
SGTC_385 1494-0393 12.4 µM -1.53190081532866 0.0659258689417015 no 3158 0.0627734561494219 4482 3090647
SGTC_2820 7989630 71.43 µM -1.53252092957553 0.0658409155091636 no 3159 0.0626969684344164 4543 2984098
SGTC_2194 5927483 104.545 µM -1.53941310124592 0.064902415483074 no 3160 0.0618517388172442 4548 760979
SGTC_1059 3448-6867 171 µM -1.54298995430311 0.0644194696722325 no 3161 0.0614166066647261 4479 3934407
SGTC_3016 9080866 49.47 µM -1.54376889767419 0.0643146681133429 no 3162 0.0613221642931116 4492 17066299
SGTC_1359 1582-0056 520 nM -1.54577445987534 0.0640454430397058 no 3163 0.0610795236219697 4553 3661189
SGTC_2244 6635614 200 µM -1.55211558615468 0.0631999779803567 no 3164 0.0603172846278014 4472 836499
SGTC_2259 7964009 200 µM -1.55348904686093 0.0630180040605609 no 3165 0.0601531719983134 4536 313134
SGTC_2277 7947813 106.88 µM -1.5549354243922 0.0628268106448366 no 3166 0.0599807247800136 4537 1246798
SGTC_1071 trifluoperazine 6.31 µM -1.55831122443164 0.0623823298114417 no 3167 0.0595797447284255 4578 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3234 9132280 49.47 µM -1.55869314597813 0.06233219820927 no 3168 0.0595345123957107 4544 17612295
SGTC_2739 tacrine 100.86 µM -1.56169334458118 0.0619394796806547 no 3169 0.0591801237111219 4585 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2882 9058044 58.44 µM -1.56278999712943 0.0617964134577002 no 3170 0.059050998869489 4540 18076804
SGTC_406 estrone 100 µM -1.56381706534401 0.0616626590568631 no 3171 0.0589302677169399 4526 5870 A steroid.
SGTC_120 rhodamine 6G 52.259 µM -1.56475290066013 0.061540982769655 no 3172 0.0588204296368386 4528 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_834 0312-0008 75.7 µM -1.56505089614226 0.0615022771072419 no 3173 0.0587854879416001 4555 6385573 YIL048W NEO1
SGTC_2297 7971671 152.32 µM -1.57193777632136 0.0606130493653487 no 3174 0.0579824912705695 4527 909016
SGTC_126 0417-1624 672.48 µM -1.57355999659519 0.06040506040017 no 3175 0.0577946038178657 4579 41912 YDL195W SEC31
SGTC_1106 tegaserod maleate 11.7 µM -1.5768056807782 0.0599905999639523 no 3176 0.0574201220647534 4561 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_350 k064-0020 19.8 µM -1.58855356892697 0.0585090379548249 no 3177 0.0560806089302348 4537 2790705
SGTC_3151 9099821 49.47 µM -1.5949195901315 0.0577182876886797 no 3178 0.0553651091256424 4489 17174189
SGTC_2468 5987765 72.9 µM -1.59626293743335 0.0575525035201921 no 3179 0.0552150505672616 4583 26772094
SGTC_805 3852-0218 479 µM -1.59628401289436 0.0575499055585087 no 3180 0.0552126988957859 4527 6615355
SGTC_1008 4106-0037 6 µM -1.60056922248386 0.0570235832689008 no 3181 0.0547361818131542 4572 2905394
SGTC_1952 st077036 64.1 µM -1.60143630983527 0.0569175474184161 no 3182 0.0546401579908025 4561 2937007
SGTC_1124 fisetin 1.16336 µM -1.60252613107779 0.056784493790825 no 3183 0.0545196569255637 4553 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_225 nsc-122657 1.016 µM -1.60286774476057 0.0567428374753001 no 3184 0.0544819281435011 4562 275685
SGTC_1806 st050005 60.3 µM -1.60338767691434 0.0566794832366212 no 3185 0.054424545000434 4584 5194765
SGTC_1970 st070122 35.8 µM -1.60524454079131 0.0564536773479661 no 3186 0.0542199994153996 4565 102928
SGTC_1973 st070275 50.2 µM -1.61478995021588 0.0553040677624911 no 3187 0.0531780951156303 4530 17118334
SGTC_3124 9127567 49.47 µM -1.61511976713597 0.0552646788994375 no 3188 0.0531423805149 4505 17592030
SGTC_1655 st012546 55.1 µM -1.61601345870472 0.0551580598441343 no 3189 0.0530457016810082 4545 720985 YLR208W SEC13
SGTC_812 4251-0442 148 µM -1.62178974730958 0.0544728520366299 no 3190 0.0524241872280993 4577 5723007
SGTC_1905 st060207 84.5 µM -1.62545064088597 0.0540420785981258 no 3191 0.0520332864918526 4548 1948547
SGTC_1843 st055809 45.5 µM -1.63035948632197 0.0534686970631032 no 3192 0.0515127709624351 4586 16413835
SGTC_356 1634-0012 32.5 µM -1.63531659438549 0.0528945806563776 no 3193 0.0509913483143172 4561 735457
SGTC_1723 st034307 2.5525 µM -1.63852607842135 0.0525254837132061 no 3194 0.0506559992663677 4558 867466
SGTC_3245 9134821 49.47 µM -1.64210382298816 0.0521164488632765 no 3195 0.0502842447733802 4565 17014901
SGTC_840 0245-0196 390 µM -1.64931389515584 0.0512998284408567 no 3196 0.0495416722189055 4632 3827528
SGTC_2723 salbutamol 83.58 µM -1.65021673088223 0.0511982933876576 no 3197 0.0494493080290111 4581 9884233 β2-adrenoceptor agonist
SGTC_1642 st009582 77.7 µM -1.6539492850655 0.0507802174462128 no 3198 0.0490689087695225 4560 6739311
SGTC_2226 7298446 200 µM -1.6551942639124 0.050641375990702 no 3199 0.048942549206358 4588 3283010
SGTC_3055 9094636 49.47 µM -1.65814632798299 0.050313366834687 no 3200 0.0486439674592075 4576 25236176
SGTC_783 0848-0141 92.7 µM -1.66161566419333 0.0499300492856296 no 3201 0.0482949302799843 4519 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2817 7995342 71.43 µM -1.66935918987073 0.0490828884256679 no 3202 0.0475231081742035 4551 18879975
SGTC_2114 5491910 81.25 µM -1.67048320346776 0.0489608784504912 no 3203 0.0474118999556659 4584 2849228
SGTC_718 1130-0073 349 µM -1.67556576050829 0.0484121967251527 no 3204 0.0469116400809376 4582 6740020
SGTC_1019 4262-0212 3.4 µM -1.67568078339041 0.0483998366988101 no 3205 0.0469003679219782 4577 4677213
SGTC_2495 cafestol 54.53 µM -1.67570641664045 0.0483970825677962 no 3206 0.0468978561780984 4578 16667697 An anti-infammatory.
SGTC_3249 9135183 49.47 µM -1.67914888214183 0.0480283486518749 no 3207 0.0465615157546513 4537 4902779
SGTC_254 nsc-64875 3.808 µM -1.68479759302363 0.0474281715119889 no 3208 0.0460138147379455 4587 56993
SGTC_1628 st004252 77.7 µM -1.68555102149504 0.0473485757178519 no 3209 0.0459411548581475 4575 692968
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.68982331096354 0.0468992530075457 no 3210 0.0455308813522908 4583 641818 YHR062C RPP1
SGTC_2484 5809818 12.04 µM -1.69043356598216 0.0468353516740937 no 3211 0.0454725189807374 4551 2870548
SGTC_2818 7996756 12.99 µM -1.69194132620549 0.046677769731644 no 3212 0.0453285806877369 4603 2241621
SGTC_3180 9109287 49.47 µM -1.6958610838899 0.0462700904803196 no 3213 0.0449560955520088 4613 18891271
SGTC_3114 9122766 49.47 µM -1.71504568984539 0.0443158388495855 no 3214 0.0431684252024279 4581 17176985
SGTC_814 3342-0569 96 µM -1.71545158342466 0.044275222212129 no 3215 0.0431312324638539 4629 4346283
SGTC_2917 7979103 53.79 µM -1.71927603819188 0.0438939911914076 no 3216 0.0427820604709909 4584 2980565
SGTC_1863 st057641 20.1 µM -1.7199934337478 0.0438227752100091 no 3217 0.0427168175815248 4652 3921635
SGTC_2242 6630449 61.2675 µM -1.72114600067685 0.0437085548847517 no 3218 0.0426121668597898 4597 691249 YDR170C SEC7
SGTC_2092 5303694 80.6725 µM -1.72154990953315 0.0436685840717532 no 3219 0.0425755418498709 4607 1963699
SGTC_2215 7188065 200 µM -1.72197631045311 0.0436264194545089 no 3220 0.0425369049641599 4649 940217
SGTC_2612 dictamnine 15.46 µM -1.72241107424788 0.0435834617085691 no 3221 0.0424975395031247 4512 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2106 5357045 167.29 µM -1.7231355981005 0.0435119494674008 no 3222 0.042432003332729 4613 668842
SGTC_2896 9052656 71.43 µM -1.72409532094667 0.0434173683736949 no 3223 0.0423453183241715 4276 6469436
SGTC_986 1493-0483 84 µM -1.72438726819231 0.0433886297953273 no 3224 0.0423189772211122 4577 40079
SGTC_414 piperonyl butoxide 100 µM -1.72493059221956 0.04333518718395 no 3225 0.0422699907992167 4596 5794 A potent inhibitor of cytochrome P450.
SGTC_2786 7743617 45.45 µM -1.7332423558183 0.0425242295762734 no 3226 0.0415263008088041 4529 583674
SGTC_703 3875-0075 71.8 µM -1.73419972826982 0.0424316145918326 no 3227 0.0414413255858054 4642 2850814
SGTC_1401 3807-4679 7.6 µM -1.735670800567 0.0422896229537071 no 3228 0.0413110296451393 4530 3291456
SGTC_842 0271-0008 11.1 µM -1.73837875551343 0.0420292495379561 no 3229 0.0410720487672092 4622 1221709
SGTC_1953 st076800 12.1 µM -1.7399778678138 0.0418761031825138 no 3230 0.0409314521352045 4566 297591
SGTC_132 0417-1715 25.805 µM -1.74012904997188 0.0418616479347042 no 3231 0.0409181801703675 4573 6769098
SGTC_1458 k015-0034 6.33 µM -1.74143856685615 0.0417366077711182 no 3232 0.0408033664450118 4625 3598957
SGTC_1316 1272-0050 65.9 µM -1.74309515310378 0.0415788610007221 no 3233 0.0406584975616851 4618 7340392
SGTC_2085 5307070 144.047 µM -1.7474476365072 0.0411667009567148 no 3234 0.0402798602371774 4547 2840351
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.75470746313647 0.0404866046816768 no 3235 0.0396546794052785 4549 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.75765086705062 0.0402134800147367 no 3236 0.039403466307587 4601 688798
SGTC_925 2064-1272 59.6 µM -1.76298388217866 0.0397224317818578 no 3237 0.0389516040599772 4592 6815817
SGTC_876 0720-0963 56.8 µM -1.76349951950357 0.0396752130244412 no 3238 0.0389081391258048 4613 765861
SGTC_1751 st044839 27.194 µM -1.76392195112279 0.039636563468457 no 3239 0.0388725602783283 4646 5291326
SGTC_2344 7990960 76.95 µM -1.77590252070673 0.0385531124372193 no 3240 0.037874492713279 4599 140813
SGTC_9 0092-0002 10.449 µM -1.7760105121221 0.0385434572148892 no 3241 0.0378655922579996 4616 759368
SGTC_2355 9061122 103.12 µM -1.78222636516159 0.0379910269495391 no 3242 0.0373561624928167 4620 5302957
SGTC_3152 9099253 49.47 µM -1.78780595742443 0.0375006617055726 no 3243 0.0369036596994806 4470 25236131
SGTC_2448 5185112 27.17 µM -1.79209769897733 0.0371270070480378 no 3244 0.0365586587150286 4615 5718189
SGTC_3345 9148410 3.559 µM -1.79378669033881 0.0369807940949815 no 3245 0.0364236110655104 4563 4903596
SGTC_2603 homopterocarpin 100 µM -1.81514126442125 0.0351724452896194 no 3246 0.0347511016054242 4609 101795 A weak amylase inhibitor.
SGTC_2772 vinpocetine 57.06 µM -1.82361121331702 0.0344755828977278 no 3247 0.0341054350664882 4624 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1018 4259-0013 28.1 µM -1.82664629194112 0.0342286500300705 no 3248 0.0338764841851353 4659 6801262
SGTC_174 3553-0389 74.3 µM -1.83827060753888 0.0332963119957894 no 3249 0.0330112699797893 4651 738071
SGTC_2798 7813637 45.45 µM -1.83887919900888 0.0332480812894596 no 3250 0.0329664779647571 4627 956368
SGTC_312 4092-0653 6.84 µM -1.83964469195963 0.033187497907386 no 3251 0.0329102092169844 4537 1148278
SGTC_1143 3454-2408 5.08 µM -1.83966781688995 0.033185669147815 no 3252 0.0329085106156465 4657 X1143
SGTC_204 PMA1.184 62.41 µM -1.84313445145374 0.0329124591652644 no 3253 0.0326546911798757 4628 2252213 YGL008C PMA1
SGTC_131 0141-0277 33.849 µM -1.84737678367159 0.0325806407436359 no 3254 0.032346275781117 4598 1547771
SGTC_2429 5902844 64.44 µM -1.84743073590403 0.0325764386479853 no 3255 0.0323423690139836 4630 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1753 st043925 64 µM -1.85548107875301 0.0319544248712953 no 3256 0.031763779370032 4660 670181
SGTC_627 1391-0720 175 µM -1.86015600028576 0.0315977386484695 no 3257 0.0314317290600851 4643 997839
SGTC_1496 4469-0713 57.4 µM -1.86409649523947 0.0312996491410004 no 3258 0.0311540773188244 4667 746691
SGTC_953 1188-0045 9.7 µM -1.86709608935174 0.0310742988335365 no 3259 0.0309440852218852 4611 6144426
SGTC_1446 4239-0190 62 µM -1.87339786786767 0.0306052366733916 no 3260 0.0305067321139865 4658 1340085
SGTC_2119 5528445 120.635 µM -1.88186609748031 0.0299841672496286 no 3261 0.029927099297015 4663 791935
SGTC_402 epigallocatechin gallate 10 µM -1.88284138115202 0.0299133147922006 no 3262 0.0298609336009934 4623 65064 An antioxidant.
SGTC_1927 st060202 13.8 µM -1.88840508015352 0.0295117737289283 no 3263 0.0294857949352223 4597 688887
SGTC_3120 9124077 49.47 µM -1.89029127849109 0.0293766634882694 no 3264 0.0293595072908313 4725 18774327 YGL155W CDC43
SGTC_1489 4065-0444 182 µM -1.90887963990061 0.0280724322600581 no 3265 0.028138810037093 4662 2877968
SGTC_2707 st078556 66.6 µM -1.91366813321483 0.0277443755890295 no 3266 0.0278312866439951 4596 17250899
SGTC_3013 9080133 71.4286 µM -1.91901629835241 0.0273817589185348 no 3267 0.0274911356143539 4684 17050193
SGTC_440 fluspirilene 35.1 µM -1.92136960265111 0.0272234568037994 no 3268 0.0273425639682323 4650 3396 An atypical antipsychotic.
SGTC_2497 7-hydroxyflavone 100 µM -1.92593916141225 0.0269182519076133 no 3269 0.0270559854228259 4652 5281894
SGTC_2699 st077704 54.6 µM -1.94611585392622 0.0256045793072786 no 3270 0.0258204123011628 4661 645852
SGTC_2534 helenine 20.12 µM -1.95252224678092 0.0251988662409889 no 3271 0.0254381161668321 4671 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2187 6125751 200 µM -1.95400407491947 0.0251057940288105 no 3272 0.025350367640362 4677 874498
SGTC_2785 7756463 72.73 µM -1.96698471826604 0.0243027437038487 no 3273 0.0245924862895432 4652 2201551
SGTC_3087 9117406 49.47 µM -1.97550631764207 0.0237873691291147 no 3274 0.0241053591894701 4663 42546093
SGTC_1112 tnp00069 1.16933 µM -1.97770895298351 0.0236556612577456 no 3275 0.0239807748406109 4663 145826
SGTC_253 dyclonine 31.25 µM -1.9798487948768 0.0235282959912846 no 3276 0.0238602607921657 4735 3180 An oral anasthetic.
SGTC_1555 citronellol 128 µM -1.99742699090104 0.0225037004904866 no 3277 0.0228894090968147 4682 8842 A terpine precursor.
SGTC_611 3453-1652 23.7 µM -2.00411357762233 0.0221239577001706 no 3278 0.022528947647978 4673 1560575
SGTC_2810 7959871 45.46 µM -2.02026517897684 0.0212289353786432 no 3279 0.0216779443204616 4622 2974535
SGTC_2214 7179297 48.276 µM -2.02221045982458 0.0211232353842062 no 3280 0.0215773070739957 4743 769744
SGTC_3308 9128332 17.569 µM -2.02844868656202 0.020787269776924 no 3281 0.021257237688873 4655 17332805 YDL196W YDL196W
SGTC_3174 9107204 49.47 µM -2.03068467199214 0.0206679552735304 no 3282 0.0211434961146914 4690 3938802
SGTC_2521 angolensin 13.4 µM -2.03109579284601 0.0206460806847722 no 3283 0.0211226390830507 4706 821428 A flavenoid.
SGTC_1182 1222-0449 220 µM -2.04801521602112 0.0197627031429244 no 3284 0.0202792542411096 4706 658318
SGTC_3012 9080433 71.4286 µM -2.04935712414678 0.0196940352153341 no 3285 0.0202136032925521 4690 17688859
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.05897759795415 0.0192076451226178 no 3286 0.019748192284284 4592 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1281 0884-0031 11.8 µM -2.07307873286118 0.0185131963241388 no 3287 0.0190824764403311 4707 1548255
SGTC_1090 efavirenz 20.7 µM -2.07586228127691 0.0183786697201452 no 3288 0.0189533450530328 4721 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1701 st028638 40.4 µM -2.08472914663364 0.017955678911985 no 3289 0.0185469466960419 4707 3490878
SGTC_474 dl-dihydrosphingosine 5 µM -2.08627359915851 0.0178828567550482 no 3290 0.0184769233581314 4683 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2291 7917025 104.35 µM -2.11364531590525 0.0166334540819504 no 3291 0.0172727861650542 4638 2964612
SGTC_1665 st014639 11.4 µM -2.11875041101366 0.0164088875602827 no 3292 0.0170557827901148 4754 981133 YIL048W NEO1
SGTC_2939 9044578 71.43 µM -2.12412999335349 0.0161750607755663 no 3293 0.0168296375518117 4657 2653634
SGTC_2100 5377183 190 µM -2.12612031657698 0.0160892766102007 no 3294 0.0167466213398618 4725 2844202
SGTC_2514 salinomycin 42.74 µM -2.13440127407448 0.0157365353023937 no 3295 0.0164049736948586 4690 23682228 A polyether potassium ionophore.
SGTC_2566 crystal violet carbinol 226 nM -2.13481175765698 0.0157192239890769 no 3296 0.0163881947480033 4635 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3041 9091929 49.47 µM -2.15462466523551 0.0149028561551569 no 3297 0.0155956086479772 4690 25236887
SGTC_1274 0865-0114 173 µM -2.16909888608476 0.0143297503031144 no 3298 0.0150375886280907 4724 870624
SGTC_2157 5649910 96.377 µM -2.16926792099531 0.0143231710965362 no 3299 0.0150311745939953 4707 2858091
SGTC_3030 9087619 49.47 µM -2.19629226182612 0.0133042306426726 no 3300 0.0140355156227008 4710 25236973
SGTC_2981 9013952 38.96 µM -2.20726534403816 0.0129087262324825 no 3301 0.0136477634893585 4668 2996344
SGTC_2034 5197015 53.07 µM -2.21895695051389 0.0124985521702845 no 3302 0.0132448267158578 4720 780676
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.24211005041532 0.0117194781004383 no 3303 0.0124771303009149 4721 5282309
SGTC_1512 0259-0544 12.2 µM -2.25485198360038 0.011308980704929 no 3304 0.0120713105411707 4708 18476
SGTC_380 3970-0968 6 µM -2.2962052067078 0.0100616180726441 no 3305 0.0108320754931848 4699 2891601
SGTC_2597 laccaic acid a 100 µM -2.29818379884768 0.0100050706851773 no 3306 0.0107756651967363 4704 5491415 A textile dye.
SGTC_603 3794-0023 45.9 µM -2.30673866162229 0.00976375670813653 no 3307 0.0105346967808118 4749 3802260
SGTC_743 1275-0778 158 µM -2.31945499519717 0.00941445488168125 no 3308 0.0101851893356386 4745 2849257 YMR203W TOM40
SGTC_623 k072-0108 16.9 µM -2.32199508908491 0.00934600641529225 no 3309 0.0101166000313618 4738 5382803
SGTC_742 0kpi-0133 140 µM -2.33843256350689 0.00891349649572767 no 3310 0.00968241007241378 4762 2728852
SGTC_1277 0873-0036 22 µM -2.33855645298753 0.00891030439398807 no 3311 0.00967920038655151 4766 5965735
SGTC_2189 6047310 154.431 µM -2.3472928588764 0.00868771543220749 no 3312 0.0094551923496117 4762 711535
SGTC_811 0416-0114 265 µM -2.36435898915827 0.00826692719114193 no 3313 0.00903065079916129 4749 6612453
SGTC_3255 9139072 49.47 µM -2.36705981289078 0.00820200183140793 no 3314 0.00896501741506631 4747 17646060
SGTC_261 5-fluorouridine 15.376 µM -2.37723079071397 0.00796150324830087 no 3315 0.00872158523637852 4759 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_115 0527-0192 112.043 µM -2.38438293302202 0.00779612122365602 no 3316 0.00855389507919543 4713 4233931
SGTC_1311 1190-0148 100 µM -2.39883335532095 0.00747117644270915 no 3317 0.00822369898878064 4760 1961333
SGTC_3182 9108849 49.47 µM -2.43145941713047 0.00678105023398361 no 3318 0.00751906644379123 4739 17133045
SGTC_3112 9123419 49.47 µM -2.43418654246536 0.00672599965100936 no 3319 0.00746265046061571 4772 17015854
SGTC_1782 st039423 80.636 µM -2.43596013866178 0.00669040959332889 no 3320 0.00742616055953104 4745 2068169
SGTC_3083 9117465 49.47 µM -2.44689284611946 0.00647467993411655 no 3321 0.00720468355403679 4726 16420915
SGTC_1350 1495-0454 146 µM -2.45032107956612 0.00640831150243761 no 3322 0.007136443870799 4765 1069057
SGTC_1999 st074831 12.5 µM -2.45270321752547 0.00636254999667166 no 3323 0.00708936329983763 4740 17112523
SGTC_3257 9139206 32.98 µM -2.45441794764392 0.00632978883681469 no 3324 0.00705564322685578 4760 4910041
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.45647204002704 0.00629074055818075 no 3325 0.0070154360037502 4728 364106
SGTC_1337 1486-1011 40.3 µM -2.48330155850913 0.00579995196703569 no 3326 0.00650854194515233 4761 X1337
SGTC_2267 7931562 200 µM -2.52670990265637 0.0050775883884708 no 3327 0.00575682815602118 4736 934880
SGTC_443 clozapine 122 µM -2.52860034180571 0.00504803455379739 no 3328 0.00572591732948125 4760 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2826 7992541 19.48 µM -2.57078690472595 0.00442716625166338 no 3329 0.0050733870381481 4747 2985066
SGTC_63 0099-0242 26.702 µM -2.58566636133362 0.00422503050393372 no 3330 0.00485954789498853 4764 3898502 YLR359W ADE13
SGTC_845 0330-0138 4.51 µM -2.6128674605907 0.00387673695285037 no 3331 0.00448930571207554 4755 9039800
SGTC_40 0327-0103 19.753 µM -2.6514497392798 0.00342682019706646 no 3332 0.00400735203222505 4676 409036
SGTC_2149 5554786 194.827 µM -2.6578880084757 0.00335648786652261 no 3333 0.00393160089017667 4780 745063 YPR165W RHO1
SGTC_1023 4482-3888 16 µM -2.67395816417422 0.00318656374078969 no 3334 0.003748090116707 4764 3303168
SGTC_2265 7929201 200 µM -2.71285114911896 0.00280690995796745 no 3335 0.00333535316833325 4752 1265108
SGTC_298 1391-0729 10 µM -2.71615074024081 0.00277665924436851 no 3336 0.00330229196455141 4767 3237558
SGTC_375 3970-0961 9.27 µM -2.76720965836681 0.00234458800290632 no 3337 0.00282691908577172 4772 2898222
SGTC_53 0973-0023 39.979 µM -2.87687659835094 0.0016152840428867 no 3338 0.00200816312617068 4755 674768
SGTC_1184 1269-1718 139 µM -2.88119277373718 0.00159135502957002 no 3339 0.00198086626487635 4795 5403821
SGTC_391 gliotoxin 8.33 µM -2.88612158942779 0.0015644249392102 no 3340 0.00195010723780904 4793 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_306 1672-3436 11.6 µM -2.96964986594592 0.00116690203665697 no 3341 0.00149069673920179 4793 6797378
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.97689502362333 0.00113720545142113 no 3342 0.00145591847090037 4776 6710655
SGTC_145 3737-0113 38.366 µM -3.02572597809784 0.00095444407028478 yes 3343 0.00124018489875261 4778 6849351
SGTC_3029 9088683 49.47 µM -3.03220387013632 0.000932338710281918 yes 3344 0.00121387587634431 4795 25236615
SGTC_2768 sulfasalazine 50.2 µM -3.07396190736518 0.000800765265039357 yes 3345 0.00105618201214143 4780 5384001 An antioxidant and salicylic acid derivative.
SGTC_54 0159-0055 9 µM -3.09280320538074 0.000747188729013046 yes 3346 0.000991377855709367 4782 3319099
SGTC_2216 7189485 200 µM -3.11034289258456 0.00070030140642406 yes 3347 0.000934351377095708 4809 731273
SGTC_3244 9134489 49.47 µM -3.15421454669677 0.00059464810256103 yes 3348 0.000804653641564194 4797 16584271
SGTC_843 0310-0051 143 µM -3.177901342251 0.000543927370573434 yes 3349 0.00074172609699177 4798 2065037
SGTC_1757 st041620 31.8375 µM -3.34832877423131 0.000281350196004401 yes 3350 0.000406502506321227 4788 5289815
SGTC_2425 5628681 7.85 µM -3.37405405973199 0.000254011983571765 yes 3351 0.000370349099651534 4800 5714958
SGTC_2639 lactacystin 53 µM -3.37736305795167 0.000250681067823278 yes 3352 0.00036592191951992 4797 3870 A proteasome inhibitor.
SGTC_2054 5233173 129 µM -3.55946585495073 0.000119048744071597 yes 3353 0.000185804921278392 4799 6889
SGTC_2751 anetholtrithion 17.25 µM -4.2084669037751 6.25077059570743e-06 yes 3354 1.28554589117234e-05 4799 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_758 0868-0029 16 µM -6.80565871678619 4.48025472076689e-13 yes 3355 5.02939564952322e-12 4783 762687
SGTC_44 0929-0055 61.211 µM -8.55159102726789 1.00827973696683e-19 yes 3356 6.07016378593755e-18 4766 1379590