SGTCid condition conc unit SOL3|YHR163W.score SOL3|YHR163W.strain.pval SOL3|YHR163W.strain.significant SOL3|YHR163W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_210 3551-0445 56.827 µM 12.4444098705298 1.24057238210681e-37 yes 1 7.49944146088518e-36 12 2865180 YOR207C RET1 SGTC_211 3455-0679 143.504 µM 10.8060533350313 7.31849053350171e-29 yes 2 1.61118578694496e-27 1 748649 SGTC_209 4077-0173 175.592 µM 8.70407989869874 2.15382411609447e-19 yes 3 1.60080722688937e-18 2 15993494 SGTC_1364 1653-0028 37.6 µM 8.16224678305431 2.81700320786753e-17 yes 4 1.64424728325984e-16 1 5718652 SGTC_773 4358-1457 44.6 µM 8.04330128348974 7.8827432894519e-17 yes 5 4.37249834612144e-16 6 1186886 SGTC_373 0844-0104 25.9 µM 7.32843784865893 2.80590372949141e-14 yes 6 1.16425451311647e-13 16 5375804 SGTC_3123 9126162 49.47 µM 7.32635296695768 2.85218110756437e-14 yes 7 1.18250200433615e-13 1 25239884 SGTC_1635 st007035 42.4 µM 6.50881782516866 1.23119208028689e-11 yes 8 3.7872255993305e-11 127 3716403 SGTC_2754 granisetron 64.02 µM 5.80470011384011 1.31719559590201e-09 yes 9 3.22406535877659e-09 6 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2949 9072542 2.23 µM 5.67720204265632 2.90678913010693e-09 yes 10 6.84578619059636e-09 9 16457352 SGTC_223 busulfan 5 mM 5.50043412241515 8.47282669953348e-09 yes 11 1.89428642971234e-08 3 2478 A DNA alkylator. SGTC_1137 ixabepilone 100 µM 5.39633704550345 1.56720163548843e-08 yes 12 3.40075632958431e-08 9 154225 A novel microtubule stabilizer. SGTC_1741 st038134 10.228 µM 5.26083396214981 3.43228075192699e-08 yes 13 7.17017431783224e-08 9 1272587 SGTC_1827 berberine 7.24 µM 5.21689328990685 4.40791834258311e-08 yes 14 9.09745044879008e-08 6 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_362 0310-0100 9.03 µM 5.05248210386332 1.10449487575626e-07 yes 15 2.18052615090066e-07 8 790235 SGTC_2313 7726885 200 µM 4.72886877227306 6.21428397592571e-07 yes 16 1.12887122684148e-06 20 726423 SGTC_1202 1988-0068 29.6 µM 4.52789352830732 1.72190687844402e-06 yes 17 2.97872920693648e-06 13 2850480 SGTC_2756 carbadox 75.1 µM 4.44260475105542 2.62098196714848e-06 yes 18 4.44381700265522e-06 43 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3143 9086658 49.47 µM 4.32033376492321 4.72551632326722e-06 yes 19 7.78966908201741e-06 32 25236626 SGTC_1032 k061-1018 98.7 µM 4.27214015857117 5.93665380136087e-06 yes 20 9.68029094577001e-06 13 4005393 SGTC_1749 st037932 54.2 µM 4.10221489149136 1.30256949245922e-05 yes 21 2.04606971614409e-05 26 594497 SGTC_1613 st002381 52.1 µM 4.08860965239918 1.38540630447879e-05 yes 22 2.16983200263346e-05 20 551167 SGTC_1326 1431-2094 10.8 µM 3.94699109907696 2.60308122772471e-05 yes 23 3.95697489360107e-05 35 616278 SGTC_2882 9058044 58.44 µM 3.90328139601988 3.14962891978955e-05 yes 24 4.74486312842947e-05 17 18076804 SGTC_1607 st000305 50.6 µM 3.85443047594478 3.88848780720666e-05 yes 25 5.79996699930482e-05 14 5457690 SGTC_225 nsc-122657 1.016 µM 3.84428809982394 4.06117693554744e-05 yes 26 6.04514512586768e-05 12 275685 SGTC_1790 st045711 43.5 µM 3.7203115570528 6.8502531301613e-05 yes 27 9.94885812699416e-05 16 585119 SGTC_1612 st002233 45.4 µM 3.70338191160051 7.34841074643623e-05 yes 28 0.000106372117441976 25 1035021 SGTC_140 0062-0056 502.533 µM 3.61708938443699 0.000104629656335922 yes 29 0.000148967220078703 31 3758964 SGTC_1362 1611-0397 101 µM 3.59533750330716 0.00011424265792255 yes 30 0.000161985648651931 28 27816 SGTC_329 k048-0121 21.3 µM 3.58848196099256 0.000117440243841967 yes 31 0.0001663045010258 19 6832902 SGTC_364 0083-0097 67.7 µM 3.58594600986457 0.000118644206175484 yes 32 0.000167929222827905 35 5207356 SGTC_847 0342-0274 5.54 µM 3.57957889806367 0.000121718278591247 yes 33 0.000172074166912068 26 18097 SGTC_1627 st003713 25.6 µM 3.54399792145477 0.000140318161409031 yes 34 0.000197054176247537 99 16195070 YER133W GLC7 SGTC_1001 4048-4355 44.4 µM 3.51241378660537 0.000159028702202411 yes 35 0.000222028023792294 51 21824233 SGTC_1897 st060201 15 µM 3.48041228504493 0.00018034971431766 yes 36 0.000250321363060519 29 611878 SGTC_695 3505-6186 243 µM 3.47075464375152 0.00018729152950772 yes 37 0.000259498993419738 36 1819379 SGTC_854 0422-0053 192 µM 3.35726977195081 0.000289898549905845 yes 38 0.000393581342674574 31 3596728 SGTC_1799 st045822 46.1415 µM 3.31207802719857 0.000343758595429138 yes 39 0.000463028566898623 30 3674992 SGTC_1565 sinapyl alcohol 95.1 µM 3.30285143095913 0.000355840430308686 yes 40 0.000478535399549872 58 5280507 A phenol propionate derived from cinnamic acid. SGTC_2312 7706453 155.7 µM 3.29808450658788 0.000362235982611584 yes 41 0.000486734160320048 51 976098 SGTC_2484 5809818 12.04 µM 3.28216114141287 0.000384381925497461 yes 42 0.000515073586310771 32 2870548 SGTC_1840 st055363 71 µM 3.25138026191142 0.000430795995101287 yes 43 0.000574230697722148 36 676033 SGTC_2465 5809242 33.21 µM 3.249858104751 0.00043322086685734 yes 44 0.000577313021066079 13 2731748 SGTC_2280 7785178 200 µM 3.24133749911675 0.000447029928831687 yes 45 0.000594851205333214 27 2954328 SGTC_1352 1496-0991 99 µM 3.20380510595696 0.000512852077240869 yes 46 0.000678121258002332 53 3000039 SGTC_112 phenothiazine 287.218 µM 3.20072869584701 0.000518626955530262 yes 47 0.000685402686836887 30 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_224 benfluorex 43.875 µM 3.19267269894426 0.000534035574963231 yes 48 0.000704813121122067 21 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1724 st037281 8.293 µM 3.15038214250133 0.000622103548529183 yes 49 0.000815285150381171 86 574124 YDL195W SEC31 SGTC_2040 5100729 123 µM 3.13235365487652 0.000663575378431625 yes 50 0.000867054271590919 68 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_748 act1.228 77.9 µM 3.11881947452156 0.000696369014607998 yes 51 0.000907885874012544 121 4421505 YNR035C ARC35 SGTC_1273 0849-0096 14.1 µM 3.10039332905264 0.000743420888103853 yes 52 0.000966319061462046 50 5286025 SGTC_2959 9079155 11 µM 3.05328178666366 0.000877354786578939 yes 53 0.00113176639180283 66 16189457 SGTC_2481 5478948 45.16 µM 3.04784912227732 0.000894149398214648 yes 54 0.00115242809410649 89 77792 SGTC_1142 3253-1408 9.78 µM 3.04247423764388 0.000911055730887919 yes 55 0.00117320950719832 38 256655 SGTC_2000 st075254 36.4 µM 3.03070554256511 0.000949103849578332 yes 56 0.00121991529783145 39 17234175 SGTC_1691 st019933 84.6 µM 3.01446916143867 0.00100399370102338 no 57 0.0012871469017331 48 6176082 SGTC_1451 4152-0210 104 µM 2.99424162513249 0.00107644813219786 no 58 0.00137563984080261 73 659563 SGTC_133 0724-0033 378.92 µM 2.99376984936203 0.00107819383412185 no 59 0.00137776858062814 63 280309 SGTC_168 3970-0862 530.542 µM 2.98485047138871 0.00111169024555396 no 60 0.00141858488605948 220 3135186 SGTC_2895 9054447 58.44 µM 2.97937519630545 0.00113272209117029 no 61 0.00144418433040569 38 2697450 SGTC_2881 9058953 51.95 µM 2.97066889243143 0.00116691686120179 no 62 0.00148575982015995 69 17122249 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.96195655756364 0.00120207923146531 no 63 0.00152845455653223 82 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2864 9034755 47.6 µM 2.93189668539744 0.00133097517853887 no 64 0.00168449401373988 51 4930451 SGTC_5 0352-0601 109.883 µM 2.9260491704598 0.00135747126283846 no 65 0.00171648336618388 43 762456 SGTC_1264 0783-0040 158 µM 2.9071161799493 0.00144660037092542 no 66 0.00182388845201839 78 2855798 SGTC_1950 st077106 7.18 µM 2.90504683417711 0.00145665911922932 no 67 0.00183599075443175 83 13831864 SGTC_1747 st037496 66.6 µM 2.89705537208522 0.00149610643007003 no 68 0.00188341632095777 76 723305 SGTC_2114 5491910 81.25 µM 2.86354633217025 0.00167234683609365 no 69 0.00209463770726455 57 2849228 SGTC_2687 chenodiol 100 µM 2.73767584968827 0.00251620170398486 no 70 0.00309375150640883 87 5702181 A cholesterol synthesis inhibitor. SGTC_2838 9002687 71.43 µM 2.73097818400312 0.00257038580618981 no 71 0.00315733257701572 95 6457060 SGTC_2197 6588183 93.1375 µM 2.71347696013123 0.00271698333605511 no 72 0.00332905990087144 69 884136 SGTC_2520 obtusaquinone 4.71 µM 2.7014426490815 0.00282212345548444 no 73 0.00345196929760154 74 5967872 SGTC_1771 st048882 4.1505 µM 2.69740228495056 0.00285823737656815 no 74 0.0034941395483408 89 4580403 SGTC_2427 5545055 42.75 µM 2.67645925119968 0.00305219680851093 no 75 0.00372023064562825 90 5372858 SGTC_3088 9117578 49.47 µM 2.67621179505916 0.00305455777750713 no 76 0.0037229787433166 51 678341 SGTC_2054 5233173 129 µM 2.64927999957741 0.00332155952702588 no 77 0.0040331735499456 164 6889 SGTC_3275 9138069 49.47 µM 2.64852171461697 0.00332937192627382 no 78 0.00404223276962128 50 17617007 SGTC_2112 5488546 200 µM 2.64358285762783 0.00338066106176711 no 79 0.00410168424385593 91 600757 SGTC_480 am 92016 50 µM 2.62949227177354 0.00353091494314366 no 80 0.00427562377518757 81 2129 K+ channel blocker. SGTC_2260 7964312 200 µM 2.62149592311203 0.00361882550444646 no 81 0.00437724046982133 81 231951 SGTC_2884 9058502 51.95 µM 2.58636364158516 0.00402878506057176 no 82 0.00484972700055925 108 6471554 SGTC_526 4469-0568 170 µM 2.58543546532068 0.00404015837753842 no 83 0.00486280387127618 117 2901964 SGTC_2078 5212016 200 µM 2.58311179878914 0.00406875734890328 no 84 0.00489567942258846 74 1899708 SGTC_1294 1000-1494 117 µM 2.58092926685561 0.00409578416803645 no 85 0.00492673841865505 109 712797 YDL207W GLE1 SGTC_11 0438-0307 1.3 µM 2.55710502876943 0.00440142441951792 no 86 0.00527736721018115 92 4011476 SGTC_3132 9126706 49.47 µM 2.54216105419124 0.00460338790283587 no 87 0.0055084698143431 110 850858 SGTC_1211 1056-0033 32.3 µM 2.5403955290899 0.00462778664920472 no 88 0.00553635841232633 73 6741922 SGTC_3294 9122953 26.2835 µM 2.51876259598661 0.00493625090663498 no 89 0.00588840155435903 115 16459826 SGTC_1356 1502-0781 85.8 µM 2.5115065878937 0.00504374363146755 no 90 0.00601085210125917 102 567702 SGTC_2095 5432005 200 µM 2.50133744064608 0.00519789956374626 no 91 0.00618626141969551 88 783734 SGTC_1062 mesoridazine 14.2 µM 2.48712428118926 0.0054203819017743 no 92 0.00643902008892229 105 4078 A neuroleptic. SGTC_2831 7999036 19.48 µM 2.48061659880519 0.00552504406097459 no 93 0.00655776802600568 174 2988270 SGTC_1097 itavastatin 7.23 µM 2.4689095477878 0.00571785478012438 no 94 0.00677627352605859 133 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1423 4048-0112 5.59 µM 2.4569849111386 0.00592036618815541 no 95 0.00700542856501784 121 X1423 SGTC_3078 9116413 49.47 µM 2.45630858674739 0.00593204023622115 no 96 0.00701862804941235 131 17177322 SGTC_2950 9072895 21.46 µM 2.45395375140736 0.00597284652043835 no 97 0.00706475761980066 169 17332245 SGTC_1820 st053765 18.6 µM 2.4438536525303 0.0061507048764523 no 98 0.0072656598813232 127 3690829 SGTC_2654 protoveratrine a 100 µM 2.43552333652726 0.00630091242973997 no 99 0.00743513268778108 82 5702278 A heart drug and vasodilator. SGTC_2497 7-hydroxyflavone 100 µM 2.42649828826568 0.00646730369380325 no 100 0.00762266112055716 116 5281894 SGTC_45 0kpi-0036 14.9 µM 2.42006401897929 0.00658829176798995 no 101 0.00775888744559456 122 2795021 SGTC_1218 1348-1416 30.7 µM 2.41815347308002 0.00662460039066337 no 102 0.00779974790911904 117 6787668 SGTC_1105 epirubicin 18.1 µM 2.41358716340167 0.00671209755914286 no 103 0.00789817456090463 115 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_222 nsc-310342 10.666 µM 2.40632064416336 0.00685344125917815 no 104 0.00805705719939218 50 432556 SGTC_3121 9125696 49.47 µM 2.4051036589044 0.00687736856369815 no 105 0.00808393950442057 56 1235365 SGTC_1260 0700-1617 7.75 µM 2.38263403287949 0.00733259706594261 no 106 0.00859463661462437 171 2853078 SGTC_1196 1588-0294 184 µM 2.37962164690698 0.00739560363871939 no 107 0.00866521091515787 115 6144269 SGTC_960 1222-0186 7.7 µM 2.37773325576149 0.00743534377379432 no 108 0.00870971092676204 151 3126296 SGTC_859 0439-0102 54.6 µM 2.37372029823277 0.00752041951968071 no 109 0.00880494230684934 131 610143 SGTC_157 1348-1695 65.819 µM 2.37359003968659 0.00752319534446791 no 110 0.00880804870322196 209 5380510 SGTC_926 2268-1401 59.4 µM 2.35849987827588 0.00785093978710595 no 111 0.00917448290274514 142 2931578 SGTC_2582 agaric acid 100 µM 2.35502238815682 0.00792822507219765 no 112 0.00926079487566249 564 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3113 9123498 49.47 µM 2.35359750340231 0.00796008508362155 no 113 0.00929636550953052 98 8897275 SGTC_1862 st057513 3.81 µM 2.3446231840961 0.00816334785582179 no 114 0.00952315886911899 107 5393163 SGTC_124 0136-0217 7.121 µM 2.33788258873364 0.0083190034270118 no 115 0.00969666985984271 180 3976905 SGTC_1327 1436-0082 2.18 µM 2.31696628746855 0.0088187207037993 no 116 0.0102527841437541 143 15992205 SGTC_3120 9124077 49.47 µM 2.28561829679874 0.00961691346323994 no 117 0.0111382994079885 114 18774327 YGL155W CDC43 SGTC_1255 0566-0045 221 µM 2.26766163217765 0.0101020097726084 no 118 0.0116749190352526 187 2788469 SGTC_2767 sibutramine 71.45 µM 2.25929546491863 0.0103352199824628 no 119 0.0119325059166066 158 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_703 3875-0075 71.8 µM 2.25642949690957 0.0104161823919044 no 120 0.012021873036135 109 2850814 SGTC_1640 st009078 66.4 µM 2.25254602625863 0.0105267705726349 no 121 0.0121438937760047 118 690618 SGTC_3158 9100007 49.47 µM 2.25105482307935 0.010569506067265 no 122 0.012191032642119 126 19297233 SGTC_1688 st021091 57.6 µM 2.24706232355641 0.0106846695718088 no 123 0.0123180221781565 107 3656366 SGTC_1661 st013063 9.66 µM 2.2312205944531 0.011152460407115 no 124 0.0128332602244398 192 721395 SGTC_1280 0880-0253 10.1 µM 2.23032479712311 0.0111794363945857 no 125 0.0128629440523529 158 6836607 SGTC_1045 1348-1485 165 µM 2.22959391777304 0.0112014880608068 no 126 0.0128872070045406 215 6810614 SGTC_2206 7254556 146.969 µM 2.21845864035635 0.011542161758461 no 127 0.0132617883173935 92 4398905 SGTC_2812 7970281 58.44 µM 2.208344761532 0.0118593484350139 no 128 0.0136101246342867 196 2233435 SGTC_136 0097-0015 404.482 µM 2.19873689307664 0.0121676424362993 no 129 0.013948318020402 173 4861337 SGTC_2677 mitomycin C 100 µM 2.19596185505263 0.0122579699025197 no 130 0.014047336875523 121 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_533 1222-0222 6.71 µM 2.1873596250252 0.0125416742270017 no 131 0.0143581405832254 191 3982874 SGTC_1481 3346-2004 36 µM 2.18489728207609 0.012623922407 no 132 0.014448189424847 149 2770522 SGTC_1932 st074806 40.9 µM 2.1672051319633 0.0132287271418611 no 133 0.0151096081268391 182 17251235 SGTC_2993 9054257 71.4286 µM 2.16109855939277 0.0134432132731835 no 134 0.0153438634219147 248 6470217 YGL055W OLE1 SGTC_654 1124-0271 80.9 µM 2.15798502286183 0.013553723660729 no 135 0.0154644981350861 205 5403748 SGTC_273 hydroxyurea 18.1 mM 2.15486781901362 0.0136651488256338 no 136 0.0155860896473546 221 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1277 0873-0036 22 µM 2.14158926757233 0.0141486922379559 no 137 0.0161132740647683 216 5965735 SGTC_2592 piperlongumine 83.33 µM 2.13857889071778 0.0142603438407225 no 138 0.0162348943088283 197 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_667 1498-1044 59 µM 2.1344620391854 0.0144142614428426 no 139 0.0164024889300524 187 6739982 SGTC_2438 5259590 200 µM 2.13233583021845 0.0144943130883085 no 140 0.0164896242640897 169 1201127 SGTC_48 0382-0018 55 µM 2.12730444690426 0.0146852700487894 no 141 0.0166973977597919 158 762596 SGTC_322 k048-0136 19.3 µM 2.12458218514992 0.0147894879551852 no 142 0.0168107458358331 155 6823282 SGTC_333 3486-0131 40.1 µM 2.11959396262252 0.0149821061898983 no 143 0.0170201510336447 165 6744690 SGTC_3331 9141060 1.957 µM 2.11426758670106 0.0151901588600654 no 144 0.0172462095699599 175 4906567 YPR165W RHO1 SGTC_955 1216-0110 33 µM 2.11408051649039 0.0151975108726821 no 145 0.0172541954861672 269 3619719 SGTC_346 4513-0042 7.16 µM 2.10677322145087 0.0154870951705663 no 146 0.0175686208764494 220 2827372 SGTC_2265 7929201 200 µM 2.10246291774802 0.0156601213925807 no 147 0.0177563723534423 201 1265108 SGTC_2157 5649910 96.377 µM 2.09708484178489 0.015878334108488 no 148 0.0179930327916678 201 2858091 SGTC_2967 9089538 49.85 µM 2.09494660309611 0.0159658136421732 no 149 0.018087869721194 218 728216 SGTC_1000 4048-0884 8.67 µM 2.0947789497965 0.0159726901009296 no 150 0.0180953236004243 203 13040088 SGTC_3010 9080089 71.4286 µM 2.09315300273252 0.0160395116705323 no 151 0.0181677492721478 179 17027233 SGTC_2961 9083290 32.55 µM 2.09248017607077 0.0160672328436796 no 152 0.0181977916394272 171 17741490 SGTC_1470 k295-0292 231 µM 2.091303185692 0.016115824840194 no 153 0.0182504472181835 192 5045612 SGTC_2968 9090663 33.37 µM 2.08367491480424 0.0164338205534223 no 154 0.0185948737538511 221 25236811 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.0786100923728 0.0166479099819252 no 155 0.0188266013031928 262 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3255 9139072 49.47 µM 2.07350737819194 0.0168660099649113 no 156 0.0190625425904208 181 17646060 SGTC_3116 9124943 49.47 µM 2.06691819522611 0.0171512555954584 no 157 0.0193709314626316 190 41905195 YPL160W CDC60 SGTC_156 3474-0145 5.642 µM 2.06553754156225 0.017211543654435 no 158 0.0194360836097691 238 2265471 SGTC_1175 0741-0056 27.6 µM 2.06086451835608 0.0174169426792773 no 159 0.0196579835795549 221 765927 SGTC_1884 5633444 25 µM 2.0592612379538 0.0174878941990237 no 160 0.0197346098017142 247 5724239 SGTC_336 4111-0029 111 µM 2.05760962020172 0.0175612427353628 no 161 0.0198138112170653 169 3131175 SGTC_2030 5175110 200 µM 2.04950898199392 0.0179248070022775 no 162 0.0202061852262469 185 2831986 SGTC_3279 9140807 49.47 µM 2.04795849623989 0.0179951212595543 no 163 0.0202820331529065 166 45595718 SGTC_2931 9014674 55.67 µM 2.04162095320077 0.0182849780765532 no 164 0.020594572608909 208 2996810 SGTC_37 0566-0070 1.56 µM 2.04014064469866 0.0183532523561913 no 165 0.0206681597524585 228 1626686 SGTC_2434 5670830 169.91 µM 2.029756886687 0.0188382994985386 no 166 0.0211906286590824 233 1549830 SGTC_2181 6316240 54.2555 µM 2.01838021435915 0.0193822062578471 no 167 0.0217758391931329 199 12779990 SGTC_335 4077-0256 27.6 µM 2.01201793983996 0.019692156433245 no 168 0.022109022960112 223 3121989 SGTC_1158 4092-0494 91.8 µM 2.01129691650707 0.0197275464657431 no 169 0.0221470520057722 202 1148199 SGTC_1660 st012960 28.1 µM 2.00184276154942 0.0201966028748917 no 170 0.0226508226431089 245 24207266 SGTC_1443 4112-3303 14 µM 1.9944997975121 0.0205674090995772 no 171 0.0230487310394919 218 704433 SGTC_1333 1482-0047 286 µM 1.99423584036535 0.0205808451352372 no 172 0.023063143551862 243 3811116 SGTC_1866 st057638 64 µM 1.99109457292415 0.0207413145807982 no 173 0.0232352454988833 190 688802 SGTC_3177 9107506 49.47 µM 1.98816498734258 0.0208919239706486 no 174 0.0233967229394615 142 8897194 SGTC_2626 ethyl orsellinate 100 µM 1.98793006930596 0.0209040410496447 no 175 0.0234097123137279 217 75653 A natural product. SGTC_812 4251-0442 148 µM 1.98461218318586 0.0210758140114901 no 176 0.0235938179075681 178 5723007 SGTC_1863 st057641 20.1 µM 1.98222492258022 0.0212001443008857 no 177 0.0237270362404607 235 3921635 SGTC_1564 D-Arginine 115 µM 1.9704776956354 0.0218210224079513 no 178 0.0243918243875502 247 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_709 3807-1509 243 µM 1.965359662338 0.0220962914927268 no 179 0.024686312359866 167 1886677 YPL242C IQG1 SGTC_1979 st071809 45.3 µM 1.961236192122 0.0223201954936095 no 180 0.0249257383825555 202 4976333 SGTC_3130 9127414 49.47 µM 1.95723899510781 0.0225390668245153 no 181 0.0251596880580981 200 1494646 SGTC_1559 coumarin 343 70.1 µM 1.95630994475018 0.0225901964685943 no 182 0.0252143266994265 191 108770 A hepatotoxic, DNA x-linker. SGTC_1575 cyproterone acetate 48 µM 1.95224628827225 0.0228149876770843 no 183 0.0254544855029407 244 9880 An androgen receptor antagonist and liver toxin. SGTC_497 capsazepine 133 µM 1.95087089938532 0.0228914963834796 no 184 0.0255362025808997 208 2733484 A calcium channel blocker. SGTC_992 3909-8734 162 µM 1.94578481849152 0.0231762997105805 no 185 0.0258402965031635 217 4288319 SGTC_697 0508-1955 564 µM 1.94014369765048 0.0234956667833734 no 186 0.0261811143454587 262 6243113 SGTC_2815 7968870 71.43 µM 1.9355040682884 0.0237611025751692 no 187 0.0264642349582404 281 2977326 YHR190W ERG9 SGTC_460 trequinsin 123 µM 1.93509232468939 0.0237847799769575 no 188 0.0264894836098994 171 5537 A vasodilator. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.93507392526946 0.023785838502284 no 189 0.0264906123558685 246 688751 SGTC_1811 st050069 61.5 µM 1.92913548376966 0.0241295545674816 no 190 0.0268570224537665 168 3877702 SGTC_2771 fluoxetine 41.05 µM 1.92675396897725 0.024268563629402 no 191 0.0270051492601027 212 3386 A selective serotonin reuptake inhibitor. SGTC_396 dithiazanine 1.25 µM 1.9225470536934 0.0245157646137455 no 192 0.0272684794216687 179 10578 An antihelmenthic. SGTC_845 0330-0138 4.51 µM 1.92120059628028 0.0245953283745583 no 193 0.027353211516592 230 9039800 SGTC_125 0133-0007 11.75 µM 1.91195597961861 0.0251474748452488 no 194 0.0279409202640788 211 26541 SGTC_2378 9074213 121.43 µM 1.90369546716097 0.0256495969335938 no 195 0.0284749285642348 268 657714 SGTC_1397 3532-0190 20.1 µM 1.90176796856394 0.0257679616033816 no 196 0.0286007478018663 179 5322280 SGTC_2315 7733312 200 µM 1.90104060337262 0.025812746604858 no 197 0.0286483472455074 226 726316 SGTC_9 0092-0002 10.449 µM 1.89747354320409 0.0260333200686961 no 198 0.0288827336810364 251 759368 SGTC_1399 3562-5772 25 µM 1.89506083715384 0.0261834047070395 no 199 0.0290421711349952 202 23847490 SGTC_2705 st078069 42.8 µM 1.88940390846063 0.0265381378359762 no 200 0.0294188637919645 215 1530061 SGTC_2922 7999257 32.47 µM 1.88699554441172 0.0266903748751036 no 201 0.0295804624693269 199 2988377 SGTC_1984 st072354 53.1 µM 1.88000597723054 0.0271363335385519 no 202 0.0300536316536839 220 5762938 SGTC_963 1269-2853 151 µM 1.87867822341099 0.0272217477096637 no 203 0.0301442215080228 255 3668223 SGTC_2953 9074162 66.49 µM 1.87658980978832 0.0273565487471054 no 204 0.0302871675457 221 16451992 SGTC_2871 9038510 12.99 µM 1.86494259701795 0.0281185912442903 no 205 0.0310947253894093 261 4945164 SGTC_1425 4048-4433 7.33 µM 1.86390113306133 0.0281875836817104 no 206 0.0311677947975738 278 23734946 SGTC_2528 xanthyletin 44.79 µM 1.86228119188526 0.0282951777450164 no 207 0.0312817325779986 239 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1896 st058441 89 µM 1.86213683348479 0.0283047823786586 no 208 0.0312919026507647 230 688759 SGTC_414 piperonyl butoxide 100 µM 1.85976761138252 0.0284628025138466 no 209 0.0314592057962288 219 5794 A potent inhibitor of cytochrome P450. SGTC_2906 7926292 26.41 µM 1.85372766579035 0.0288689723937774 no 210 0.0318890657958379 275 2966319 SGTC_448 monastrol 171 µM 1.8451642160806 0.0294530890802048 no 211 0.0325068270790474 246 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_669 0108-0021 26.2 µM 1.83426610369419 0.0302106103186325 no 212 0.0333072515775147 419 17201 SGTC_2020 4017018 200 µM 1.83002613204887 0.0305096594745217 no 213 0.0336230156707216 265 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.82858283047003 0.0306120146433974 no 214 0.0337310633667098 354 688664 SGTC_1750 st081859 2.357 µM 1.82857609098991 0.0306124932559241 no 215 0.0337315685635386 500 5291695 SGTC_2683 piperine 63.03 µM 1.82587023481552 0.0308051543330493 no 216 0.0339349053383044 224 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1181 1222-0449 220 µM 1.82215970084725 0.0310709809940702 no 217 0.0342153786492537 265 658318 SGTC_3274 9138298 49.47 µM 1.82030007678758 0.031204918758937 no 218 0.0343566598554577 288 17015756 SGTC_2097 5376186 200 µM 1.81859752559094 0.0313279619126401 no 219 0.0344864278092647 288 742755 SGTC_1136 pergolide 1.05886 µM 1.81792323519017 0.0313768035771651 no 220 0.0345379332261734 388 47811 A dopamine receptor agonist. SGTC_79 0052-0007 94.094 µM 1.81609497182655 0.0315095491849516 no 221 0.0346779024487718 281 2801472 SGTC_947 3447-0010 211 µM 1.8125499907859 0.0317682641628168 no 222 0.0349506284750371 255 748350 SGTC_2723 salbutamol 83.58 µM 1.80065557509945 0.0326491790946511 no 223 0.0358785918847292 162 9884233 β2-adrenoceptor agonist SGTC_1847 st056231 15 µM 1.79650714983129 0.0329611154697773 no 224 0.0362069483157782 346 5393180 SGTC_948 3448-0295 75.3 µM 1.79465996208402 0.0331008009628036 no 225 0.0363539466499674 322 678569 SGTC_2394 5221648 200 µM 1.78264782649688 0.0340211090992027 no 226 0.0373218246331912 345 788586 SGTC_2482 5981709 142.65 µM 1.77553579338251 0.0345758440248434 no 227 0.0379047304529632 336 877755 SGTC_685 1278-0033 54.9 µM 1.77056122500081 0.0349682569371061 no 228 0.0383168473573305 326 3590572 SGTC_1389 3405-0187 19 µM 1.76536459746863 0.0353820829824038 no 229 0.0387512546574518 293 799890 SGTC_2681 menadione 3.18 µM 1.76232370029133 0.0356260975463325 no 230 0.0390073108863283 302 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_855 0428-0020 25 µM 1.76079271111637 0.0357494717343271 no 231 0.0391367469886765 260 6812414 SGTC_3087 9117406 49.47 µM 1.75710057231986 0.0360484420815946 no 232 0.0394503341038087 277 42546093 SGTC_1258 0671-0043 57.1 µM 1.75500950135266 0.0362186725012896 no 233 0.039628841286298 324 4298767 SGTC_1038 k292-0204 154 µM 1.75153353018415 0.0365031011269128 no 234 0.0399270254214259 296 4454212 SGTC_3151 9099821 49.47 µM 1.7506345630947 0.0365769577073172 no 235 0.040004438852453 278 17174189 SGTC_843 0310-0051 143 µM 1.74721120214627 0.0368593313246937 no 236 0.0403003546447493 293 2065037 SGTC_2795 7780010 54.55 µM 1.73543269970821 0.0378445183727425 no 237 0.0413320961828931 307 953673 SGTC_2432 5630864 12.22 µM 1.73487138461262 0.0378919996830193 no 238 0.0413817943276746 314 5714970 SGTC_1081 sertraline 6 µM 1.72955808153259 0.0383438608732865 no 239 0.0418546304429554 358 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1363 1636-0063 10.4 µM 1.72872152006612 0.0384154035442387 no 240 0.0419294739452751 331 6072185 SGTC_1682 st012968 530 nM 1.72497161731322 0.0387374331196804 no 241 0.0422662938156675 265 24207270 SGTC_1603 st002045 67.8 µM 1.72422230723486 0.0388020443439489 no 242 0.0423338592860569 290 5887985 SGTC_1426 4048-4480 71.7 µM 1.7131779616453 0.0397645936996444 no 243 0.0433399023792458 314 14224343 SGTC_868 0527-0199 213 µM 1.7127526187887 0.0398020484221931 no 244 0.0433790301319776 328 2849450 SGTC_204 PMA1.184 62.41 µM 1.7048031104177 0.0405073561329921 no 245 0.0441155756170936 354 2252213 YGL008C PMA1 SGTC_342 k048-0088 23.3 µM 1.70265233104608 0.0406999148055286 no 246 0.0443165752967278 315 6820570 SGTC_2403 6032726 181.2 µM 1.69757276970163 0.0411576362101513 no 247 0.0447942129246768 344 2881040 SGTC_360 0957-0399 1.01 µM 1.69475910763919 0.0414129673279813 no 248 0.0450605638690911 355 6752301 YPR165W RHO1 SGTC_809 3998-0021 90 µM 1.68972590506042 0.0418729159856703 no 249 0.045540202438523 281 715485 SGTC_2512 diallyl trisulfide 49.23 µM 1.68654216010311 0.0421659854546273 no 250 0.0458457108875048 255 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_8 0354-0001 70 µM 1.68112667244211 0.0426683021988134 no 251 0.0463691563004393 439 4993152 SGTC_1232 0279-0259 161 µM 1.68046210585077 0.0427302763581168 no 252 0.0464337206049892 351 1560000 SGTC_2810 7959871 45.46 µM 1.67919118501616 0.0428489987157547 no 253 0.0465573946942848 399 2974535 SGTC_105 0111-0055 734.78 µM 1.67835326772415 0.042927418007577 no 254 0.0466390774429318 265 5179370 SGTC_1387 3342-1166 1.8 µM 1.67816382041552 0.0429451641320219 no 255 0.0466575612772651 221 3418228 SGTC_819 1013-0258 27.7 µM 1.67665852669418 0.0430863804921547 no 256 0.0468046374798317 358 5753198 SGTC_664 1222-0054 14.9 µM 1.67215803404991 0.0435108244191431 no 257 0.0472465816624929 347 6813991 SGTC_3243 9134147 49.47 µM 1.67024638652636 0.0436921312211119 no 258 0.0474353129139128 272 24282180 SGTC_550 4123-0385 25.7 µM 1.66973845095876 0.043740407832256 no 259 0.0474855613161825 332 5731123 SGTC_2115 tiliquinol 12.7705 µM 1.66734317421551 0.0439686466205195 no 260 0.0477230931674853 286 71208 A bioactive hydroxyquinoline. SGTC_2229 7354935 190 µM 1.66520435405657 0.0441732592413277 no 261 0.0479359963042402 251 318112 SGTC_334 1502-1024 68.5 µM 1.66458152605263 0.0442329868743401 no 262 0.0479981367854588 349 3296216 SGTC_1901 st060216 58.6 µM 1.66373520614606 0.0443142511237382 no 263 0.0480826786976919 329 688792 SGTC_1587 estradiol valerate 56.1 µM 1.663433535725 0.04434324680797 no 264 0.0481128424242268 344 13791 A steroid. SGTC_2848 9016370 25.97 µM 1.65903637623824 0.0447676271527021 no 265 0.048554231231077 388 7894410 SGTC_2210 7115885 190.385 µM 1.65703353554727 0.0449620071658889 no 266 0.0487563475966936 330 2927039 SGTC_363 0455-0021 3.06 µM 1.65530658132133 0.0451301567269621 no 267 0.0489311623087903 392 4597466 SGTC_2399 5884133 200 µM 1.65015512365171 0.0456347500936428 no 268 0.0494556063551887 382 722445 SGTC_1752 st044819 83.042 µM 1.64883962462222 0.0457643296548363 no 269 0.0495902473798138 351 441209 YML126C ERG13 SGTC_2474 5321570 43.32 µM 1.64806050304764 0.0458412141860937 no 270 0.0496701281222086 308 2841384 SGTC_427 1354-0053 47.3 µM 1.64548743891221 0.046095864554125 no 271 0.0499346654643834 367 6813657 SGTC_2611 pyromycin 23.93 µM 1.64135406151182 0.0465073130998021 no 272 0.0503619699844067 367 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2908 7930301 100 µM 1.6300897723757 0.0476435689115953 no 273 0.051541262503539 393 2223178 SGTC_306 1672-3436 11.6 µM 1.62969640465842 0.0476836471049985 no 274 0.0515828388154256 355 6797378 SGTC_1025 k007-0731 70 µM 1.62599166292679 0.0480624299559915 no 275 0.0519757144610246 346 6256118 SGTC_3215 9129942 49.47 µM 1.62251005998701 0.0484205896575022 no 276 0.0523470904308837 307 17682944 SGTC_3335 9143315 29.6265 µM 1.61450770025692 0.0492519015818769 no 277 0.0532086739815861 343 4899691 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.61027905966639 0.0496957672734033 no 278 0.0536684742977164 369 390807 SGTC_3051 9093778 49.47 µM 1.6026655733467 0.0505029697641792 no 279 0.0545042540316542 272 17217378 SGTC_1619 st003326 88.7 µM 1.6010837770949 0.0506719795540241 no 280 0.0546791824305445 326 2849032 SGTC_1463 k081-0032 34.1 µM 1.59672271545957 0.0511402785093563 no 281 0.0551637649355522 278 977755 SGTC_141 0443-0274 32.331 µM 1.59666395545248 0.051146611703364 no 282 0.0551703171831474 504 1627241 SGTC_3241 9133421 49.47 µM 1.58977679003606 0.0518932488050265 no 283 0.0559425636857799 262 17018221 SGTC_316 k060-0003 58.6 µM 1.58154635502771 0.0527968409548635 no 284 0.0568765843648778 359 6152314 SGTC_1878 temozolomide 1 mM 1.57915473634365 0.0530617363629209 no 285 0.0571502846312875 326 5394 DNA alkylating agent. SGTC_1020 4335-0961 93.3 µM 1.57783098619754 0.0532088072337673 no 286 0.0573022215956145 360 669075 SGTC_3016 9080866 49.47 µM 1.57127018893918 0.0539424984055826 no 287 0.0580599513148954 393 17066299 SGTC_723 4182-0001 115 µM 1.56618957655277 0.0545161453828241 no 288 0.0586521211026157 368 744821 YLR208W SEC13 SGTC_1604 st002052 72.4 µM 1.55947301590476 0.0552818983184507 no 289 0.0594422332088639 400 6254834 YHR062C RPP1 SGTC_3235 9132602 49.47 µM 1.55802031968178 0.055448631869557 no 290 0.0596142156831966 424 4912240 SGTC_2126 5251174 33.877 µM 1.55721950364809 0.0555407153390194 no 291 0.0597091896537792 475 790722 SGTC_2678 equilin 100 µM 1.55540979501689 0.0557492530243031 no 292 0.059924251394072 402 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2885 9057732 51.95 µM 1.55353513206071 0.0559659266005796 no 293 0.0601476714190166 384 6471414 SGTC_1756 st041558 35.5 µM 1.55222562808076 0.0561176727590739 no 294 0.0603041229934371 420 3955792 SGTC_349 k015-0014 24 µM 1.55050568591715 0.0563174734786142 no 295 0.0605100949204287 378 2196908 SGTC_3048 9093155 49.47 µM 1.54971185178792 0.0564098798399124 no 296 0.0606053461040269 316 25236002 SGTC_3175 9106517 49.47 µM 1.54943726254347 0.0564418712383265 no 297 0.0606383210197099 375 41468073 SGTC_998 3996-0085 177 µM 1.54875697399133 0.0565211907899786 no 298 0.0607200760714144 438 715391 SGTC_1415 3966-0071 78.1 µM 1.54810424285165 0.0565973797811106 no 299 0.0607986003713799 382 2893185 SGTC_3268 9137683 49.47 µM 1.54601343264846 0.05684197105321 no 300 0.0610506618760119 326 1953228 SGTC_2826 7992541 19.48 µM 1.54366313921283 0.0571179107232188 no 301 0.0613349802332853 386 2985066 SGTC_2082 5219693 150 µM 1.54355313522936 0.0571308516891799 no 302 0.0613483128711682 409 2834649 SGTC_2343 7990716 14.84 µM 1.53747529912442 0.0578494468421633 no 303 0.0620884796676949 403 6456862 SGTC_1683 st010134 710 nM 1.52706018910786 0.0590973461017021 no 304 0.0633730226211057 414 3818134 SGTC_765 1319-0117 244 µM 1.51652758988412 0.0603806972902584 no 305 0.064692999688872 372 3487746 YGL099W LSG1 SGTC_724 3910-0327 137 µM 1.51597626659811 0.0604484696438825 no 306 0.0647626768709878 430 2885483 SGTC_1316 1272-0050 65.9 µM 1.50769795679742 0.0614732672308148 no 307 0.0658159243506119 390 7340392 SGTC_2496 diffractaic acid 79.83 µM 1.50639095874917 0.061636297691958 no 308 0.0659834201510166 453 94870 An apoptosis inducer which activates caspases. SGTC_977 1348-1378 135 µM 1.50468028198765 0.0618501915361421 no 309 0.0662031474455864 415 X977 SGTC_3019 9081971 49.47 µM 1.49978913351417 0.0624649515577504 no 310 0.0668345165085803 419 16451803 SGTC_1826 st055655 41.6 µM 1.49882242472274 0.0625870174817286 no 311 0.0669598527314718 433 676168 SGTC_236 1509-0011 5.31 µM 1.49806903426804 0.0626822766452375 no 312 0.0670576576942263 733 3107280 SGTC_106 0092-0003 11.579 µM 1.49445549572375 0.0631407463499818 no 313 0.0675283029018028 323 1072148 SGTC_2794 7785382 27.27 µM 1.49245181674679 0.0633960873270947 no 314 0.0677903698553984 508 2205081 SGTC_1113 artemisinin 1.17947 µM 1.48352421609298 0.064543566104766 no 315 0.0689675937149475 439 2240 An anti-malaria and mitochondrial poison. SGTC_2051 5263410 176 µM 1.48211800365979 0.0647257705085867 no 316 0.0691544495707512 431 227584 SGTC_3029 9088683 49.47 µM 1.48022890525932 0.064971171370076 no 317 0.0694060844640123 410 25236615 SGTC_2944 9067346 25.62 µM 1.47243681387286 0.0659910327531007 no 318 0.0704514790300392 452 6473075 SGTC_2842 9000675 19.48 µM 1.471927127346 0.0660581724482737 no 319 0.0705202785994014 419 2989072 SGTC_1670 st016595 4.04 µM 1.47159670216262 0.0661017267750762 no 320 0.0705649083265454 447 597879 SGTC_2217 6934799 96.0675 µM 1.46947433716037 0.0663820125707469 no 321 0.070852088741175 406 675606 SGTC_768 0384-0033 77.3 µM 1.46873382640376 0.066480022870378 no 322 0.0709524993885765 530 3965305 YMR134W ERG29 SGTC_2622 2-methoxyxanthone 59.94 µM 1.46428900671256 0.0670706730078046 no 323 0.071557499794672 441 71034 A hepatoprotective. SGTC_64 000l-0018 272.079 µM 1.46403063823278 0.0671051307298072 no 324 0.0715927886167682 583 6811119 SGTC_794 k038-0031 316 µM 1.45638731685423 0.0681306995109299 no 325 0.0726427898491438 548 6624242 SGTC_137 0438-0332 85.389 µM 1.45294663402099 0.06859629564973 no 326 0.0731192858075827 599 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1267 0828-0272 9.49 µM 1.45013753765131 0.0689782415456545 no 327 0.0735100845691775 495 745334 SGTC_1160 4092-0570 10.5 µM 1.44866167847143 0.0691795662348552 no 328 0.0737160436575228 477 4994975 SGTC_1759 st043059 70 µM 1.44855766739558 0.0691937716388698 no 329 0.0737305752325068 487 669426 SGTC_1703 st026983 48.3 µM 1.44811771105643 0.069253883922546 no 330 0.0737920665470209 466 1104023 SGTC_3214 9129694 49.47 µM 1.44606223115746 0.0695352622489868 no 331 0.0740798739723126 419 17158655 SGTC_447 ml7 120 µM 1.44553110514385 0.0696081119713957 no 332 0.0741543812482088 450 4216 Selective myosin light chain kinase inhibitor. SGTC_150 3970-0969 77.2 µM 1.4328991030179 0.0713581002404199 no 333 0.0759433368323274 552 6615640 SGTC_371 0195-0006 7.36 µM 1.43216221930324 0.0714612183220362 no 334 0.07604870067628 381 3928593 SGTC_2784 7567673 72.73 µM 1.43214794683933 0.0714632167113602 no 335 0.0760507425328063 494 3471247 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.43071733267926 0.0716637448688629 no 336 0.0762556218212373 502 16486 A toxic proline analog. SGTC_803 4488-1585 147 µM 1.42971635140713 0.0718043081790727 no 337 0.0763992226564433 420 747204 SGTC_982 1491-0518 27.5 µM 1.42953222015478 0.0718301879159439 no 338 0.0764256605277212 423 3091256 SGTC_2070 5230947 200 µM 1.4286604155343 0.0719528176061605 no 339 0.0765509301880936 467 2835538 SGTC_3055 9094636 49.47 µM 1.42683290071961 0.0722104001801475 no 340 0.0768140326774225 429 25236176 SGTC_1667 st014849 34.6 µM 1.42242394633404 0.0728347374843161 no 341 0.0774516077733856 469 5348460 SGTC_901 1112-0062 60.1 µM 1.41698802272342 0.0736101792704326 no 342 0.0782432146483567 434 1908457 SGTC_1298 1079-1278 263 µM 1.41673465344241 0.0736464761051917 no 343 0.0782802606888623 479 2840950 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.4156156445427 0.0738069452537622 no 344 0.078444034152641 439 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3084 9116877 49.47 µM 1.41386415519565 0.0740586502467535 no 345 0.0787008961237178 385 27241325 SGTC_2382 9035899 200 µM 1.41364047295089 0.0740908425910117 no 346 0.0787337457431782 482 6462679 SGTC_1523 st012844 44.7 µM 1.41161953982452 0.0743821800120641 no 347 0.0790310079189787 481 4274103 SGTC_195 4234-0266 16.654 µM 1.40893495770214 0.0747705406496543 no 348 0.0794272007997247 533 2303354 SGTC_3034 9090421 49.47 µM 1.40645142839917 0.0751311922228055 no 349 0.0797950590188166 420 17173761 SGTC_1966 st070145 16.1 µM 1.40526991883278 0.0753032328770279 no 350 0.0799705148961678 472 3748532 SGTC_2234 tolnaftate 200 µM 1.40360999204779 0.0755454434017841 no 351 0.0802175090232044 371 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2665 lovastatin 100 µM 1.40292769273761 0.0756451740318012 no 352 0.0803192009783744 456 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1671 st016596 74.5 µM 1.39423299633046 0.0769248624892008 no 353 0.0816236284422573 511 2829167 SGTC_2380 9035439 200 µM 1.39120558460979 0.0773742794912374 no 354 0.082081547129906 544 6462575 SGTC_2184 6075246 200 µM 1.38782184002699 0.0778789509598874 no 355 0.0825956513318623 494 2267320 SGTC_1842 st055362 61.2 µM 1.387814965715 0.0778799787715436 no 356 0.0825966982315015 527 676032 SGTC_972 1319-0219 195 µM 1.38676241336134 0.0780374724524155 no 357 0.0827571109303088 497 23903702 SGTC_3350 9150499 3.57 µM 1.38591936261174 0.0781637925382185 no 358 0.0828857638357604 560 4910996 YPR165W RHO1 SGTC_1723 st034307 2.5525 µM 1.38428802619333 0.0784086672254538 no 359 0.0831351394605318 479 867466 SGTC_2780 5215298 71.43 µM 1.38420326585087 0.0784214062067414 no 360 0.0831481118243773 515 2834131 SGTC_937 3122-0005 46.7 µM 1.38341953304095 0.0785392709862073 no 361 0.0832681323354981 515 759535 SGTC_158 k038-0087 26.446 µM 1.3822425696277 0.0787165254916414 no 362 0.0834486166156138 613 X158 SGTC_781 4335-2806 94.4 µM 1.3818028351693 0.0787828286589408 no 363 0.0835161241451437 551 845254 SGTC_1107 amlodipine 47 µM 1.37999324143026 0.079056124652427 no 364 0.0837943628900988 505 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1031 k035-0009 16 µM 1.37759507012493 0.0794194167574168 no 365 0.084164171939791 551 5180959 SGTC_3203 9113543 49.47 µM 1.37662400587385 0.0795668793786232 no 366 0.0843142624927427 491 17018012 SGTC_1574 spiramycin 23.7 µM 1.37529056448863 0.0797697088472979 no 367 0.0845206902886684 500 6419898 An antibiotic and protein synthesis inhibitor. SGTC_555 4296-0685 37 µM 1.36771381940949 0.0809296367935977 no 368 0.0857008362669488 508 2908540 YHR072W ERG7 SGTC_3326 9140064 16.379 µM 1.3671511288842 0.0810162846413376 no 369 0.0857889700111286 466 1868434 SGTC_2817 7995342 71.43 µM 1.36582802414456 0.0812203033702151 no 370 0.0859964740861142 424 18879975 SGTC_1190 1486-1332 13 µM 1.36504026641171 0.0813419571826425 no 371 0.0861201972949261 481 4150046 SGTC_78 0336-0123 156.75 µM 1.36387859423677 0.0815216055140498 no 372 0.0863028894498803 451 6765896 SGTC_173 1273-0061 2.693 µM 1.36211675251607 0.0817946386264626 no 373 0.0865805210962538 565 2847414 YPL266W DIM1 SGTC_1931 st074438 57.1 µM 1.36203581647949 0.0818071978458637 no 374 0.0865932910460099 465 2787313 SGTC_2127 5253358 187.912 µM 1.35775976372748 0.0824728016053056 no 375 0.0872699630851335 452 20612 SGTC_321 4534-3890 65.3 µM 1.35756228486333 0.0825036390636536 no 376 0.0873013086034791 500 699746 SGTC_1581 himbacine 57.9 µM 1.35540790210848 0.082840622391447 no 377 0.0876438166879353 531 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2624 nerol 100 µM 1.35127091618827 0.0834906216246941 no 378 0.0883043324877473 485 637566 A natural product oil. SGTC_2331 7980721 200 µM 1.3507121241181 0.0835787115094301 no 379 0.0883938334941763 525 2981221 SGTC_830 4076-0286 57.8 µM 1.3494095647776 0.0837843225084179 no 380 0.0886027251479626 673 6866659 SGTC_3031 9088762 49.47 µM 1.34849474499235 0.0839289551890414 no 381 0.0887496546108263 518 205253 SGTC_3067 9117431 49.47 µM 1.34828356715855 0.0839623689491714 no 382 0.0887835977043654 452 17150885 SGTC_3209 9113616 49.47 µM 1.3477893399465 0.0840406074381406 no 383 0.0888630737521019 551 16649353 SGTC_1740 st038286 13.222 µM 1.34709290908607 0.0841509486075529 no 384 0.0889751558043464 518 716786 SGTC_2675 theaflavin digallate 100 µM 1.34128871016695 0.0850747881808405 no 385 0.0899133669439507 530 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2998 9066762 71.4286 µM 1.34088312700661 0.0851396268393775 no 386 0.0899792006320999 579 4945196 SGTC_2340 7987427 183.45 µM 1.33612692734104 0.085902743402104 no 387 0.0907538950079165 516 2239331 SGTC_3104 9120930 49.47 µM 1.33470023779119 0.0861326461050071 no 388 0.0909872378633099 448 17014836 SGTC_1287 0971-0001 34.6 µM 1.33253602211818 0.0864822751010135 no 389 0.0913420563166126 575 4665869 SGTC_2233 sulbentine 40.3845 µM 1.3278221548702 0.0872474708735456 no 390 0.092118433060652 575 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_510 ag-490 170 µM 1.32731646077803 0.0873298588173335 no 391 0.0922020104705397 540 5328779 SGTC_1479 0549-0158 134 µM 1.32443249784912 0.0878008259424882 no 392 0.0926797237918127 588 5440202 SGTC_1887 st057648 70.8 µM 1.32404858990849 0.0878636628523292 no 393 0.0927434539408769 530 688672 SGTC_949 1165-0505 146 µM 1.31994003401777 0.0885382405372997 no 394 0.0934275199333476 569 6244267 SGTC_2710 st078562 53.7235 µM 1.31630581061254 0.0891381474796592 no 395 0.0940357106897987 508 17250908 SGTC_1734 st037168 69.4 µM 1.31541081092226 0.0892863496210874 no 396 0.0941859370637925 530 708907 SGTC_2956 9076196 2.52 µM 1.31406150609105 0.089510126122837 no 397 0.0944127534316158 550 16423868 SGTC_1291 0993-0025 5.79 µM 1.31217013970396 0.0898245029792539 no 398 0.0947313672585442 534 4353356 SGTC_263 alizarin 107.927 µM 1.31178344200586 0.0898888795615997 no 399 0.0947966066315643 615 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2002 4023503 131 µM 1.31115507882358 0.089993561204098 no 400 0.0949026877408214 665 4736863 YCR052W RSC6 SGTC_1321 1326-2144 215 µM 1.30824334997371 0.0904798209045324 no 401 0.0953953914479453 508 3513030 SGTC_51 1013-0126 23.419 µM 1.30402382119865 0.0911879414579884 no 402 0.0961127302490551 516 1627850 SGTC_1606 st000094 49.2 µM 1.2962531867685 0.0925027465754698 no 403 0.0974441354828389 572 1242210 SGTC_1159 4092-0538 61.2 µM 1.29580897474772 0.0925783296626608 no 404 0.0975206526531353 596 717301 SGTC_3148 9097893 49.47 µM 1.29420988114909 0.0928507951723678 no 405 0.0977964673015894 520 17174100 SGTC_1328 1441-0025 69.2 µM 1.2927479357203 0.0931004107579162 no 406 0.0980491263630235 497 4562601 SGTC_1695 st026914 34.495 µM 1.29252944363735 0.0931377591081739 no 407 0.0980869280547891 554 3289191 SGTC_2226 7298446 200 µM 1.29098232386954 0.0934025357379921 no 408 0.0983549034503937 483 3283010 SGTC_726 3448-4391 34.2 µM 1.29080338430622 0.0934331955879465 no 409 0.098385931989617 596 1356692 SGTC_2623 humulene 100 µM 1.29053993281253 0.0934783494036811 no 410 0.0984316281405635 476 6187145 An anti-inflammatory. SGTC_291 SEC14.278 35.5 µM 1.29023600416782 0.0935304607506537 no 411 0.0984843644323499 568 1068044 SGTC_83 0170-0301 39.027 µM 1.2889210841382 0.0937561630335841 no 412 0.098712761635562 416 3089716 SGTC_1376 2910-0861 41.3 µM 1.28733137445751 0.0940295687663782 no 413 0.0989894062308019 591 1112859 SGTC_2984 9022109 38.96 µM 1.28373547543113 0.0946501779491058 no 414 0.0996172636121034 498 6459207 SGTC_2420 aureobasidin a 50 nM 1.28261323323659 0.0948444803391752 no 415 0.0998138058209165 605 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2511 berberine 10.47 µM 1.27615739114775 0.0959679407580528 no 416 0.100949943665766 545 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1702 st027038 51 µM 1.27542365226345 0.0960962444402969 no 417 0.101079665701564 596 5521182 SGTC_2874 9043904 71.43 µM 1.27102241481233 0.0968685053955813 no 418 0.101860337274967 462 4463428 SGTC_214 4373-3496 70 µM 1.27010406049656 0.097030217000629 no 419 0.102023782725534 738 3779166 SGTC_2923 7992654 58.14 µM 1.26993976841099 0.0970591678264911 no 420 0.102053042962354 557 2985126 SGTC_2222 6885208 172.143 µM 1.26668560947397 0.0976339084817155 no 421 0.102633863792265 507 609514 SGTC_2806 7952793 58.44 µM 1.26511066604329 0.0979129651715034 no 422 0.102915829966736 569 2972490 SGTC_2063 5246145 200 µM 1.25741999575105 0.09928403763773 no 423 0.104300796186318 599 711240 SGTC_2855 9016525 58.44 µM 1.25448577107686 0.0998108261299761 no 424 0.104832747188054 584 43811474 SGTC_47 0149-0135 24.25 µM 1.25092037091322 0.100453675234273 no 425 0.105481765447267 544 5239155 SGTC_980 1473-0395 201 µM 1.2504859405135 0.100532209953489 no 426 0.10556104403106 522 768876 SGTC_174 3553-0389 74.3 µM 1.2497094213817 0.100672697779743 no 427 0.105702857224982 539 738071 SGTC_1014 4130-3005 69.3 µM 1.24891512323897 0.100816550277906 no 428 0.105848059793255 602 743608 SGTC_2015 5119600 184 µM 1.24696793772648 0.101169832071637 no 429 0.106204627023111 596 2828786 SGTC_2903 5923464 63.88 µM 1.24652371675177 0.101250554211157 no 430 0.106286093859495 557 2876576 SGTC_499 genistein 192 µM 1.24291226543494 0.101908555562303 no 431 0.106950082687474 527 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1449 4112-4002 201 µM 1.24179769645006 0.10211225555588 no 432 0.107155606436462 566 2059539 SGTC_2904 7225135 42.03 µM 1.23935662708916 0.102559422909095 no 433 0.107606728177299 606 4446116 SGTC_469 w7 172 µM 1.23712529399342 0.102969413547297 no 434 0.108020285331662 533 45115570 A P450 inhibitor. SGTC_1681 tripelennamine 100 µM 1.23547159512113 0.103274035531787 no 435 0.10832752078534 513 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2203 7227154 166.4 µM 1.23514796588284 0.103333726598283 no 436 0.108387720335296 548 896304 SGTC_3352 9151559 45.5865 µM 1.23461467803444 0.103432142310899 no 437 0.108486971818645 565 17159339 SGTC_85 0868-0259 160.055 µM 1.23439443671594 0.103472806633993 no 438 0.108527980531968 565 83173 SGTC_932 2857-0803 154 µM 1.23271588722583 0.103783107400847 no 439 0.108840891173648 638 674898 SGTC_2294 7971431 200 µM 1.22430433149666 0.105348257799212 no 440 0.110418721774575 535 5741572 SGTC_1806 st050005 60.3 µM 1.22093400718411 0.105980146951842 no 441 0.111055503628405 600 5194765 SGTC_1480 1070-0044 41.2 µM 1.22063482385603 0.106036371755818 no 442 0.11111215752093 604 3124987 SGTC_1396 3511-0007 98.6 µM 1.22016069212033 0.106125518329938 no 443 0.111201982341371 541 X1396 SGTC_2596 sinensetin 100 µM 1.21779622432482 0.106570895509976 no 444 0.111650709743504 576 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1990 st072050 59.8 µM 1.21777701285345 0.106574519749215 no 445 0.111654360983776 618 17233948 SGTC_2849 9019321 12.99 µM 1.21666320838992 0.106784790809556 no 446 0.11186619138737 565 16489627 SGTC_440 fluspirilene 35.1 µM 1.21515671394724 0.10706967242591 no 447 0.112153163104659 607 3396 An atypical antipsychotic. SGTC_1002 4049-0206 172 µM 1.21458026411456 0.107178825307701 no 448 0.112263109954526 662 4662749 SGTC_1974 st069448 26.9 µM 1.21264592053153 0.107545686675664 no 449 0.112632612077506 582 6323587 YNR016C ACC1 SGTC_2004 4023728 41.89 µM 1.20929392059513 0.108183557315516 no 450 0.113274972822226 630 360084 YDR527W RBA50 SGTC_1898 st060199 18.6 µM 1.20878732169569 0.10828019722829 no 451 0.113372281816653 586 688866 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.2080383915671 0.108423178569154 no 452 0.113516247700591 662 1377 SGTC_1611 st001856 99.4 µM 1.20800765559294 0.108429049401385 no 453 0.113522158821163 584 647478 SGTC_2304 7443016 91.4 µM 1.20745414627275 0.108534813535015 no 454 0.113628646905929 546 939854 SGTC_878 0828-0289 13.7 µM 1.20684664283695 0.108650980226074 no 455 0.11374560471542 666 745350 YLR208W SEC13 SGTC_3202 9113761 49.47 µM 1.20670784535997 0.108677533598039 no 456 0.113772338328201 678 4798415 SGTC_3263 9137018 49.47 µM 1.20598471151716 0.1088159519738 no 457 0.113911692700726 585 43844957 SGTC_1647 st011722 22.4 µM 1.20386763501629 0.109221920008391 no 458 0.114320371459517 576 2854783 SGTC_1547 harmine 94.2 µM 1.20351684157478 0.109289292695295 no 459 0.114388189044804 692 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.20324280430079 0.109341944514046 no 460 0.114441187570847 636 688669 SGTC_505 gw-5074 63.9 µM 1.2028501727103 0.109417414060308 no 461 0.114517152576807 621 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2738 aclarubicin 5.55 µM 1.20276557158735 0.109433680534286 no 462 0.114533525609255 514 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2336 9001819 198.65 µM 1.20196419483817 0.109587849441203 no 463 0.114688700375758 648 2989602 SGTC_2587 piperic acid 92.2 µM 1.19948521889684 0.110065742190243 no 464 0.115169664410786 575 5370536 SGTC_2109 5483026 200 µM 1.19832229479468 0.110290443192528 no 465 0.115395785188762 631 759335 SGTC_339 3091-4833 71.4 µM 1.19810664170448 0.110332147965887 no 466 0.115437751767803 629 3240077 SGTC_2344 7990960 76.95 µM 1.19432734941735 0.111064855040358 no 467 0.116174971667078 586 140813 SGTC_3256 9138902 49.47 µM 1.19105920288221 0.111701268340908 no 468 0.116815172112769 625 17228773 SGTC_908 3448-7491 47.7 µM 1.18876934437352 0.112148728989185 no 469 0.117265222197696 723 1203031 SGTC_3185 9108267 49.47 µM 1.18385324664147 0.113113707003569 no 470 0.118235580107815 622 4910486 SGTC_1466 k213-0079 57.5 µM 1.1782183555069 0.114227046913358 no 471 0.119354783343305 650 3657981 SGTC_784 4579-0127 173 µM 1.17635132626093 0.114597649471783 no 472 0.119727256708593 669 1948547 SGTC_1281 0884-0031 11.8 µM 1.17610218214682 0.114647168853379 no 473 0.119777023020117 660 1548255 SGTC_2180 6301957 200 µM 1.17476812474926 0.114912582476891 no 474 0.120043747935362 640 845462 SGTC_391 gliotoxin 8.33 µM 1.17251593767269 0.115361651182026 no 475 0.120494988587959 679 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1275 0867-0008 21.1 µM 1.16996538985316 0.115871715120278 no 476 0.121007448592279 655 3422836 SGTC_69 0096-0274 206.684 µM 1.16896788878284 0.116071632459391 no 477 0.121208284580017 721 6741392 SGTC_213 1246-0773 967 nM 1.16831834637452 0.116201944110607 no 478 0.121339188842185 671 6251622 SGTC_2239 6685329 187.64 µM 1.16574477704807 0.116719275888183 no 479 0.121858825218675 643 805680 SGTC_384 k007-0144 5.16 µM 1.165159316049 0.116837191280281 no 480 0.12197725518744 698 6824886 SGTC_719 2810-4230 27.3 µM 1.15017284796088 0.119884342640686 no 481 0.125036343510741 624 721079 SGTC_985 1493-0307 8.71 µM 1.14899635674371 0.120125905005892 no 482 0.125278741473396 606 3278274 SGTC_1016 4226-1401 38 µM 1.14751343139923 0.120430874147473 no 483 0.1255847426188 675 2901613 SGTC_1484 3473-2379 286 µM 1.14692843198389 0.120551331325455 no 484 0.125705600387157 768 671917 SGTC_693 4161-2696 114 µM 1.14672817498392 0.120592585711872 no 485 0.125746991054542 605 805759 SGTC_962 1254-0300 21.5 µM 1.14582754129904 0.120778245626347 no 486 0.125933258519277 659 7340576 SGTC_2423 st077119 87.2 µM 1.14545013585018 0.120856105150053 no 487 0.126011370024902 662 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2072 5231554 129 µM 1.1431249392603 0.121336577242287 no 488 0.126493360533152 675 789545 SGTC_3159 9100096 49.47 µM 1.14289635429862 0.121383883805904 no 489 0.126540813201712 641 25236875 SGTC_351 caspofungin 25 nM 1.1412017296142 0.121734997544765 no 490 0.126892992376813 796 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2712 st079126 47.7 µM 1.14028091390223 0.121926082727051 no 491 0.127084643378126 620 3152970 SGTC_981 1488-1094 54.9 µM 1.13985287118261 0.122014980686919 no 492 0.127173801211888 603 3449522 SGTC_97 0535-0701 19.132 µM 1.13977450974994 0.122031260092432 no 493 0.12719012797579 636 2832013 YGL099W LSG1 SGTC_1596 piperlongumine 63 µM 1.13961979034871 0.122063407167403 no 494 0.127222368359907 734 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_914 3820-6779 408 µM 1.13520288229145 0.122983646556341 no 495 0.128145161070713 634 2893481 SGTC_1057 3448-5381 134 µM 1.13243222570879 0.123563374619502 no 496 0.128726381475896 678 5497911 SGTC_1065 prochlorperazine maleate 2.48 µM 1.12909751988455 0.124263658031819 no 497 0.12942834872059 697 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_531 3788-1495 174 µM 1.12901497222296 0.124281028059706 no 498 0.129445758869489 663 2896655 SGTC_2656 pseudo-anisatin 100 µM 1.12582818817558 0.124952903270799 no 499 0.130119125144224 671 6708809 A neurotoxin. SGTC_58 0957-0393 9 µM 1.12360578243825 0.125422956145494 no 500 0.130590150970984 881 6997992 SGTC_2111 5486399 200 µM 1.12150480473783 0.125868459838959 no 501 0.13103652374007 743 689674 SGTC_2818 7996756 12.99 µM 1.11983467510206 0.126223390446186 no 502 0.131392109938973 604 2241621 SGTC_1710 st031758 61.5 µM 1.11561265324414 0.12712374975575 no 503 0.132293986772714 668 5394341 SGTC_1469 k284-2957 126 µM 1.10925020619979 0.128488986287536 no 504 0.133661129666519 681 23884841 SGTC_3247 9135149 49.47 µM 1.10918952261453 0.128502056414573 no 505 0.133674215763278 636 8934436 YOR116C RPO31 SGTC_698 k064-0052 127 µM 1.10735682190754 0.128897221237646 no 506 0.134069843116365 666 5088751 SGTC_2575 plumbagin 510 nM 1.10660216395433 0.12906018445446 no 507 0.134232985653192 680 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1731 st035964 63 µM 1.10615168435926 0.129157530501262 no 508 0.134330435641073 676 6739575 SGTC_3351 9150312 21.596 µM 1.10106570458768 0.130260113573349 no 509 0.135434030953874 709 4904905 SGTC_1072 oxiconazole 14.9 nM 1.09820378966572 0.130883399669759 no 510 0.136057755901755 742 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3089 9117425 49.47 µM 1.0973771729442 0.131063808530596 no 511 0.136238273926588 641 9401657 SGTC_1908 st060353 56.5 µM 1.09656763100927 0.131240657263394 no 512 0.136415221912108 764 4227716 SGTC_1152 3909-8331 15.9 µM 1.08926491059637 0.132843424637252 no 513 0.138018540902089 679 16001939 SGTC_2673 kobusone 100 µM 1.08840345822326 0.133033377200438 no 514 0.138208517577328 726 6710676 An epoxy ketone and protein crosslinker. SGTC_1524 corynanthine 62.1 µM 1.08792266351481 0.133139474981923 no 515 0.138314625044575 688 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2565 isoliquiritigenin 100 µM 1.08748276774321 0.133236598527526 no 516 0.138411755083251 570 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1250 0485-0349 40.2 µM 1.08448732562321 0.133899251304947 no 517 0.139074391793766 674 6842794 YDL195W SEC31 SGTC_2231 micatex 6.853 µM 1.08109420150619 0.134652611286519 no 518 0.139827606239026 689 20737 An antifungal of unknown mechanism. SGTC_3258 9138477 49.47 µM 1.07899357423922 0.135120459262903 no 519 0.140295296094945 725 4970355 SGTC_775 4577-0580 57.3 µM 1.07849337900142 0.135232025969234 no 520 0.140406817463877 729 2006902 SGTC_894 0960-0238 55.9 µM 1.07833535289819 0.13526728623384 no 521 0.140442062789862 749 6741907 YDL195W SEC31 SGTC_2742 clothiapine 36.27 µM 1.07801424207595 0.135338954902577 no 522 0.14051370019278 679 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1817 st052116 64.4 µM 1.07730891882275 0.135496467235631 no 523 0.140671139564399 714 4361398 SGTC_1879 gemcitabine 100 µM 1.07725985740859 0.135507428269754 no 524 0.140682095304224 737 60750 A nucleoside analog which inhibits DNA replication. SGTC_1436 4092-1007 8.32 µM 1.07649947022255 0.135677387519603 no 525 0.140851968852117 705 2881121 SGTC_866 0495-0101 262 µM 1.07609092821348 0.135768763768118 no 526 0.14094329622328 682 635694 SGTC_3306 9127676 59.7925 µM 1.07509923867837 0.135990744577124 no 527 0.141165150148573 687 41905287 SGTC_1096 rimcazole 32.2 µM 1.07190650521666 0.136707096372067 no 528 0.141881014028389 700 18528119 A dopamine reuptake inhibitor. SGTC_2701 st077767 14.721 µM 1.07164903738234 0.136764976490302 no 529 0.141938849510735 771 5721188 SGTC_1657 st012939 43.4 µM 1.0696203974615 0.137221611377759 no 530 0.142395105029414 686 24207257 SGTC_400 oxethazaine 37.5 µM 1.06782619119487 0.13762634352638 no 531 0.142799460657292 707 4621 A local anesthetic. SGTC_1392 3455-1037 33.9 µM 1.06584365981015 0.138074504205161 no 532 0.143247160446558 731 981132 SGTC_410 α-linolenic acid 100 µM 1.06544277495263 0.138165246973149 no 533 0.143337804286633 774 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_284 0988-0104 32.6 µM 1.0638824695143 0.138518818839373 no 534 0.143690972724995 773 4666532 SGTC_1975 st070967 30.8 µM 1.05813666042485 0.139826156126751 no 535 0.144996571446963 821 261391 SGTC_2726 cimetidine 79.27 µM 1.05724454750242 0.140029887278581 no 536 0.145199996873446 669 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3191 9110352 49.47 µM 1.0562686328953 0.140252987059393 no 537 0.145422751161312 722 17122424 SGTC_1074 carmofur 3.8 µM 1.05331849430094 0.140928873348881 no 538 0.146097522722748 814 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_164 4100-3994 89.624 µM 1.05294745119202 0.141014036679058 no 539 0.146182538358593 819 4615967 SGTC_3059 1327-0034 3 µM 1.05134439149273 0.141382378600969 no 540 0.146550222902351 738 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1773 st048542 73.5835 µM 1.04887459341977 0.141951149991802 no 541 0.147117920111599 731 3237138 SGTC_2555 cholic acid 100 µM 1.04882382398658 0.141962857943893 no 542 0.147129605200782 747 6708657 Influences liver metabolism. SGTC_3092 9117248 49.47 µM 1.04856566786191 0.142022401508366 no 543 0.147189032022485 813 17141857 SGTC_1377 2944-0135 198 µM 1.04500371788387 0.142845689200657 no 544 0.148010625599829 769 1894137 SGTC_1877 wortmannin 25 µM 1.04414745024998 0.14304408171894 no 545 0.148208587656202 799 312145 A covalent inhibitor of PI 3-kinase. SGTC_1792 st045773 43.6 µM 1.04308091333879 0.143291452716234 no 546 0.148455409880487 737 2919270 SGTC_381 3461-2219 42.7 µM 1.04251011818022 0.143423960714621 no 547 0.148587618434164 795 2883159 SGTC_681 1642-0006 26.6 µM 1.03994270073923 0.144020999984243 no 548 0.149183261174226 746 4446530 SGTC_3254 9136651 49.47 µM 1.03969260332114 0.144079248268078 no 549 0.149241369073035 788 16454030 SGTC_2261 9010538 184.68 µM 1.0379992018878 0.144474063396017 no 550 0.149635213328014 645 6457250 SGTC_2326 6164455 177.58 µM 1.03779187542215 0.144522451431322 no 551 0.149683480061323 699 2888790 SGTC_1486 3970-0793 4.53 µM 1.03774153511462 0.144534202030091 no 552 0.149695201126885 764 2844330 SGTC_1351 1496-0003 46.5 µM 1.03710442300859 0.144682974441963 no 553 0.14984359705326 800 3891978 SGTC_1151 3909-8316 15.3 µM 1.03178397781815 0.145929381234848 no 554 0.151086663328428 770 800431 SGTC_1854 st056233 32.9 µM 1.0275485256531 0.146926753036991 no 555 0.152081124035038 749 5393174 SGTC_3270 9137563 49.47 µM 1.02751902287579 0.146933716399433 no 556 0.152088066334423 729 17015724 SGTC_1701 st028638 40.4 µM 1.02328062594447 0.147936379881724 no 557 0.153087590668455 802 3490878 SGTC_3259 9138485 49.47 µM 1.02122938866629 0.148423275179866 no 558 0.153572885819699 847 17646153 SGTC_1360 1598-0022 39.8 µM 1.01973950205988 0.148777595736423 no 559 0.153926010964505 858 761525 SGTC_3338 9144300 39.5675 µM 1.01834251694844 0.14911033585392 no 560 0.154257604816306 793 4901274 SGTC_3317 9138495 8.753 µM 1.01711695752021 0.149402654030961 no 561 0.154548897123431 791 17020139 SGTC_2556 citropten 84.59 µM 1.01605922756791 0.149655249181029 no 562 0.15480059164336 858 2775 A potential DNA crosslinker. SGTC_501 nsc-95397 161 µM 1.01159228506983 0.150725135213581 no 563 0.155866518093811 773 262093 SGTC_2006 4011487 200 µM 1.01027718576677 0.151041085206813 no 564 0.156181254161149 815 45595294 SGTC_3343 9148379 18.9835 µM 1.01026471192492 0.15104408413095 no 565 0.156184241465934 806 1955036 SGTC_3302 9125395 16.351 µM 1.00602365697084 0.152066003082218 no 566 0.157202095149969 772 17599668 SGTC_2505 galangin 7.89 µM 1.00301197024979 0.152794476896876 no 567 0.157927542881172 722 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_417 st075190 100 µM 1.00262758511479 0.152887619141897 no 568 0.158020290564102 835 222757 SGTC_2162 5663267 200 µM 1.00107330090853 0.153264629196057 no 569 0.158395685905059 845 6456493 SGTC_919 tnp00227 403.569 nM 0.999939729181451 0.153539978589879 no 570 0.158669838144577 828 1269246 A methoxyflavone. YNL221C POP1 SGTC_1366 1683-0113 21.9 µM 0.99953314554869 0.153638819258252 no 571 0.158768245410417 778 708623 SGTC_1227 3909-8010 46.6 µM 0.997530366122494 0.15412631062237 no 572 0.159253570930137 790 15982272 SGTC_2173 5763948 167 µM 0.996294253193243 0.154427699767643 no 573 0.15955359760604 819 2867177 SGTC_2431 5490079 200 µM 0.995742840047448 0.154562270948177 no 574 0.15968755467037 810 5722345 SGTC_2727 riluzole 51.77 µM 0.991955997153169 0.155488535045195 no 575 0.160609495520427 746 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1952 st077036 64.1 µM 0.990976380733187 0.155728744823554 no 576 0.160848556807678 834 2937007 SGTC_2267 7931562 200 µM 0.989278426923504 0.156145676044911 no 577 0.161263467994742 724 934880 SGTC_1939 st074455 53.6 µM 0.989136721953611 0.156180504810476 no 578 0.161298126490158 828 1644229 SGTC_2214 7179297 48.276 µM 0.98723877718576 0.156647481959323 no 579 0.161762798047458 818 769744 SGTC_2347 9049783 174.81 µM 0.987140167042124 0.156671769444447 no 580 0.161786964467617 854 6467988 YPL169C MEX67 SGTC_2179 6298986 200 µM 0.983170071374504 0.15765165490501 no 581 0.162761871011541 800 738374 SGTC_1169 aniline yellow 25.8 µM 0.978785037914067 0.158738623391369 no 582 0.163843102016778 794 6051 A DNA damaging agent. SGTC_1459 k035-0031 35.7 µM 0.977456978440671 0.159068791740104 no 583 0.16417148324792 734 3877128 YMR208W ERG12 SGTC_2990 9074105 71.4286 µM 0.974385158961556 0.159834198191219 no 584 0.164932667777244 798 6502001 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.973096344089097 0.160156048975218 no 585 0.165252710440373 884 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_909 3448-9333 149 µM 0.972741118576896 0.160244832507925 no 586 0.165340991790155 779 3344074 SGTC_2133 5320837 200 µM 0.970861275497859 0.160715207860292 no 587 0.165808682059448 762 2841355 SGTC_1839 st053978 48 µM 0.9684983622579 0.161307734949548 no 588 0.166397768268344 837 3788398 SGTC_3192 9110362 49.47 µM 0.967341580867881 0.161598329774667 no 589 0.166686651825761 864 16649480 SGTC_574 1315-0397 40 µM 0.965422855387832 0.162081084419805 no 590 0.167166529196207 949 6794277 SGTC_2136 5328288 199.296 µM 0.964890973149595 0.162215073006368 no 591 0.167299711599177 732 262395 SGTC_1044 1222-0021 1.78 µM 0.964364388765157 0.162347798013211 no 592 0.167431634778405 817 4306703 SGTC_2024 5144227 134 µM 0.962319011364469 0.162864003427208 no 593 0.167944691002695 880 3475211 SGTC_424 splitomicin 100 mM 0.961571144646148 0.163053013665827 no 594 0.168132535988017 766 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_464 bw-b 70c 158 µM 0.961558953712344 0.163056095891807 no 595 0.168135599158053 876 5353454 SGTC_2240 6690706 185.951 µM 0.960031473258499 0.163442587439976 no 596 0.16851968751909 720 805876 SGTC_3028 9087778 49.47 µM 0.959244453242286 0.163641955671826 no 597 0.168717805484098 880 17217395 SGTC_2031 5180455 200 µM 0.953869488953247 0.165007763080884 no 598 0.170074854736273 817 29949 SGTC_264 promethazine 12.5 mM 0.94835985635729 0.166415428607681 no 599 0.171473144269003 1005 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1505 k297-0037 20.6 µM 0.946819016633415 0.166810483735702 no 600 0.17186550490579 848 4089396 SGTC_3072 9116419 49.47 µM 0.945978035160675 0.167026357574549 no 601 0.172079894739035 783 17170162 SGTC_1687 st020778 55.3625 µM 0.945605382687156 0.167122072335037 no 602 0.172174948892608 941 4259299 SGTC_828 2074-0507 139 µM 0.94115960412732 0.168266685030784 no 603 0.173311537264754 880 X828 SGTC_2747 doxorubicin 7.63 µM 0.940330462156506 0.168480713032555 no 604 0.17352403944553 685 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1416 3966-0321 25.3 µM 0.940207032094902 0.168512589232009 no 605 0.173555687715986 870 582530 YLR208W SEC13 SGTC_3336 9143619 71.43 µM 0.940053212670726 0.168552319006042 no 606 0.173595133157408 910 45595730 SGTC_2145 5634607 200 µM 0.939374136320252 0.168727788524108 no 607 0.173769343622234 812 308662 SGTC_872 0588-0139 234 µM 0.93910900080616 0.16879632990688 no 608 0.173837391747108 879 2047100 SGTC_1248 0469-0687 58.6 µM 0.938771259820937 0.168883666766099 no 609 0.173924098907445 879 4017482 SGTC_548 1436-0017 110 µM 0.938688655384576 0.168905031967332 no 610 0.173945309864453 947 9677137 SGTC_754 3474-0146 171 µM 0.938472647021267 0.168960909596513 no 611 0.174000783716371 790 24762078 SGTC_3065 9113888 49.47 µM 0.93609914086595 0.169575676532549 no 612 0.174611072674051 810 16648368 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.933701836691814 0.170198062257404 no 613 0.175228858661528 873 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2457 5731572 11.68 µM 0.933374820088504 0.170283075287959 no 614 0.175313238247941 896 2865357 SGTC_2783 7738165 71.43 µM 0.933316102697638 0.170298342663374 no 615 0.175328391732986 765 17201110 SGTC_1957 st077035 62.4 µM 0.933221590785875 0.170322918976339 no 616 0.175352784629746 902 705593 SGTC_1301 naphtanilide LB 4.81 µM 0.931544217141725 0.170759471132317 no 617 0.175786061546318 938 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_508 roscovitine 141 µM 0.930720449423609 0.170974126346075 no 618 0.175999094389395 897 160355 A CDKinase inhibitor. SGTC_38 0929-0051 58.268 µM 0.928750599119401 0.171488124321422 no 619 0.176509175729529 924 1379719 SGTC_175 3793-3120 23.7 µM 0.925366895445491 0.172373345006347 no 620 0.177387546319966 838 5322297 SGTC_2314 7727897 200 µM 0.921363886204787 0.173424340958071 no 621 0.178430238428358 875 900724 SGTC_3300 9124615 50.48 µM 0.920865079455456 0.173555588620353 no 622 0.178560436154443 877 24824903 SGTC_2979 9012552 45.46 µM 0.920398306264266 0.17367846474314 no 623 0.178682326712397 845 17100905 SGTC_1507 4075-3230 155 µM 0.92036074164493 0.173688355880427 no 624 0.178692138405666 829 659771 SGTC_2725 haloperidol 53.21 µM 0.920048056616059 0.173770702860022 no 625 0.178773823356487 902 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1677 st019204 53.9 µM 0.918777411728717 0.17410558823404 no 626 0.179106004822641 825 3945625 SGTC_2064 5220758 200 µM 0.918352004594653 0.174217798202084 no 627 0.179217304635509 913 788518 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.917403121847555 0.174468251277984 no 628 0.179465718729406 883 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2449 5812982 45.77 µM 0.915500966373377 0.174971004481214 no 629 0.179964347688548 842 776185 SGTC_3285 9112818 20.8695 µM 0.914086346507938 0.175345493980053 no 630 0.18033573811212 922 17017947 YPR165W RHO1 SGTC_717 1532-0246 73.2 µM 0.913051497438648 0.175619769121827 no 631 0.180607728911553 868 9561992 SGTC_1757 st041620 31.8375 µM 0.91161708501006 0.176000393355516 no 632 0.180985162681657 902 5289815 SGTC_2630 antimycin a 100 µM 0.910677376441168 0.176250029880114 no 633 0.181232693877189 939 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_777 1315-0167 517 µM 0.909955031402958 0.176442075349571 no 634 0.181423112815724 843 4221767 SGTC_104 0074-0074 590.992 µM 0.909561336491587 0.176546800327239 no 635 0.181526948299698 759 3943124 SGTC_1221 2958-7315 257 µM 0.907580515358807 0.177074305776053 no 636 0.182049946292285 855 4562705 SGTC_1986 st071812 45 µM 0.906265278857054 0.177425111237721 no 637 0.182397729271062 866 11838594 SGTC_1943 st076331 65.2 µM 0.904548747443511 0.177883611255733 no 638 0.18285224904905 942 24208415 SGTC_122 0236-0016 402.397 µM 0.903152526126261 0.178257104357185 no 639 0.183222474916734 969 6808838 SGTC_821 1114-0266 29.2 µM 0.900937746544387 0.178850577004662 no 640 0.18381071012424 885 3123235 SGTC_279 1273-0055 2.93 µM 0.899976310012218 0.179108590340157 no 641 0.184066428970277 993 2847562 SGTC_2921 7974240 10.71 µM 0.894390542697897 0.180612228123163 no 642 0.185556485374536 906 2979074 YDR527W RBA50 SGTC_3126 9127922 49.47 µM 0.890471793260318 0.181671830558562 no 643 0.18660630380267 895 45595682 SGTC_1226 3909-7979 35.4 µM 0.889716496929336 0.181876503612515 no 644 0.186809066807251 960 6615510 SGTC_2092 5303694 80.6725 µM 0.88895250040439 0.182083680936569 no 645 0.187014304088051 912 1963699 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.888247702825966 0.18227493572086 no 646 0.187203762024934 981 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1418 3966-3099 2.4 µM 0.885804179947696 0.182938984866152 no 647 0.187861528510373 933 740335 SGTC_1919 st067113 52.3 µM 0.883824182546035 0.183478172628971 no 648 0.188395565003097 897 1268243 SGTC_1503 4585-0012 61.3 µM 0.883486724814141 0.183570166947619 no 649 0.188486675976271 923 2922052 SGTC_1930 st074634 34.3 µM 0.883198484021732 0.183648766999723 no 650 0.188564520270459 939 684253 YOR116C RPO31 SGTC_1206 3978-0017 132 µM 0.881258783254307 0.184178247015345 no 651 0.189088884610224 891 3873677 SGTC_2772 vinpocetine 57.06 µM 0.877545765100063 0.185194436297019 no 652 0.190095136292162 906 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2982 9019404 25.97 µM 0.877322086681322 0.185255764237631 no 653 0.190155859484649 868 22333232 SGTC_2729 fluphenazine 10.66 µM 0.875601282772173 0.185727994268111 no 654 0.190623413903284 969 3372 An atypical antipsychotic. SGTC_1121 fusaric acid 630.51 nM 0.871039110800947 0.186983574067384 no 655 0.191866399217341 934 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_66 0109-0187 42.4 µM 0.869313171604074 0.187459944997011 no 656 0.192337930205096 855 759417 SGTC_3180 9109287 49.47 µM 0.868193104201129 0.187769492169259 no 657 0.192644314319427 884 18891271 SGTC_3320 9137005 35.139 µM 0.867402734849354 0.187988112287907 no 658 0.192860691959738 884 4908713 SGTC_1193 1488-0126 41.5 µM 0.867069914873457 0.188080218957358 no 659 0.192951851738271 985 1384710 SGTC_721 1187-1332 279 µM 0.866367271288708 0.188274764370051 no 660 0.193144393037719 849 25730 SGTC_771 0250-0039 27.3 µM 0.864105758115376 0.188901766380332 no 661 0.193764898069585 920 3005115 SGTC_3179 9107801 49.47 µM 0.863060714919256 0.189191937547563 no 662 0.194052042965328 967 4818259 SGTC_2872 9044037 25.97 µM 0.862735174995412 0.189282384391073 no 663 0.194141543996079 956 6465195 SGTC_1936 st074407 74.3 µM 0.861750988688102 0.189555989032174 no 664 0.194412280247823 1013 809813 SGTC_677 0929-0063 136 µM 0.861594990237377 0.189599379066336 no 665 0.194455214390333 909 1539583 SGTC_89 0302-0250 142.109 µM 0.859767063710765 0.19010826104427 no 666 0.194958729173983 1064 4203518 YLR208W SEC13 SGTC_230 MPP+ 141.667 µM 0.857658104857926 0.190696422179441 no 667 0.195540640128516 908 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2799 7812892 81.82 µM 0.857435081600432 0.190758685688296 no 668 0.195602239055185 981 20205235 SGTC_1236 0330-0013 258 µM 0.857390267276759 0.190771198431315 no 669 0.195614618173334 931 4617066 SGTC_450 aminopyrene 156 nM 0.857103116294455 0.190851386679011 no 670 0.19569394954587 948 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2699 st077704 54.6 µM 0.855928252638936 0.19117968816331 no 671 0.196018733197899 943 645852 SGTC_1318 1280-3875 124 µM 0.853446195241159 0.191874406700906 no 672 0.196705956558061 948 373245 SGTC_34 0469-0683 81.75 µM 0.851365253916522 0.192458043703264 no 673 0.197283243410776 981 3690923 SGTC_2418 pentamidine 31.67 µM 0.848642807274376 0.193223239105976 no 674 0.198040039772937 957 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1867 st057372 64 µM 0.84714599044501 0.193644737953817 no 675 0.198456876666692 1007 688837 SGTC_3079 9117512 49.47 µM 0.846234942293459 0.193901560481237 no 676 0.198710846332937 1035 7185044 SGTC_1457 k015-0032 57.3 µM 0.84546108268985 0.194119872820208 no 677 0.198926726289389 957 4302660 SGTC_463 ikarugamyin 104 µM 0.844061873629015 0.194514981448202 no 678 0.199317415687221 997 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3166 9102297 49.47 µM 0.841792499046198 0.195156847180127 no 679 0.199952055644883 973 25237072 SGTC_166 k072-0058 166.424 µM 0.840684003770595 0.195470839355949 no 680 0.200262492129201 1047 5846229 SGTC_2952 9073731 13.78 µM 0.839128872523173 0.195911862377466 no 681 0.200698497799803 1039 16457353 SGTC_2636 apigenin dimethyl ether 100 µM 0.835739501799895 0.196875150910548 no 682 0.201650733768824 967 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_651 3253-0966 34.4 µM 0.833548141823309 0.197499478068229 no 683 0.202267829319594 1012 781462 SGTC_1310 1188-0297 994 nM 0.829887864782126 0.198544971357239 no 684 0.20330109331058 986 1588352 SGTC_433 pimozide 108 µM 0.82957307439512 0.198635041288722 no 685 0.203390102722733 928 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2357 9067248 200 µM 0.829433140741954 0.198675087952276 no 686 0.20342967750754 958 9150235 SGTC_1343 1487-0095 224 µM 0.828069611075108 0.199065562066236 no 687 0.203815539194344 1000 4560101 YGL055W OLE1 SGTC_3154 9100113 49.47 µM 0.827482450608152 0.199233849588924 no 688 0.203981832483913 1001 25237525 SGTC_3246 9135460 32.98 µM 0.82748196717366 0.199233988182581 no 689 0.203981969433637 944 41446951 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.823946810817129 0.200249018297525 no 690 0.20498489039572 1004 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1513 0337-0559 19 µM 0.82338586164187 0.200410365746742 no 691 0.205144300260372 926 775073 SGTC_2697 mebhydrolin 72.4 µM 0.821090787038237 0.201071317683401 no 692 0.205797278688492 1019 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1182 1222-0449 220 µM 0.82099522666669 0.201098866162415 no 693 0.205824493568087 976 658318 SGTC_640 3381-0960 37.1 µM 0.820453855102502 0.201254977389241 no 694 0.205978712453922 1071 1745025 SGTC_2190 6049624 200 µM 0.819357955945936 0.201571215869466 no 695 0.206291107654968 979 2265554 SGTC_2732 terfenadine 20 µM 0.81745233972627 0.202121819004975 no 696 0.206834987654798 1010 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_283 0987-0079 11.7 µM 0.815857026210807 0.202583455519187 no 697 0.207290956530976 1060 411556 SGTC_2823 7987624 58.44 µM 0.814476281584262 0.202983510474935 no 698 0.207686077243844 1004 2239440 SGTC_713 1488-1073 324 µM 0.814378421416724 0.203011882231453 no 699 0.207714098268504 1033 3312542 SGTC_911 3456-4043 236 µM 0.811927683049651 0.20372317569324 no 700 0.208416564317554 1045 914281 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.810303474328227 0.204195397756462 no 701 0.208882889507709 966 15053 SGTC_2159 5658611 73.75 µM 0.810285146127755 0.204200730210005 no 702 0.208888155206788 1056 793844 SGTC_2364 9055074 200 µM 0.808536573040536 0.204709845815407 no 703 0.209390880462035 1014 6470630 SGTC_1531 st059297 52.4 µM 0.807318969206126 0.205064809619473 no 704 0.209741368977548 1042 7566702 SGTC_1075 aripiprazole 15.2 µM 0.806580546967948 0.205280257372067 no 705 0.209954092499229 1088 60795 An atypical antipschotic. YIL048W NEO1 SGTC_519 k048-0011 62.8 µM 0.805182467649244 0.205688539877863 no 706 0.210357196096778 1006 6836379 SGTC_1663 st014140 55.4 µM 0.805142370055672 0.205700256723401 no 707 0.210368764002647 1162 4207120 SGTC_2356 9061756 188.97 µM 0.804841871514906 0.205788077467496 no 708 0.210455467845481 1025 20104043 SGTC_1214 0358-0031 63.7 µM 0.803324774867454 0.206231788768135 no 709 0.210893520940483 994 4301366 SGTC_2424 5537928 59.2 µM 0.802441320297498 0.206490437318282 no 710 0.211148859597577 1084 5382802 SGTC_2293 7624732 200 µM 0.800454909675481 0.207072699106103 no 711 0.21172363907461 1037 894453 SGTC_3155 9099265 49.47 µM 0.800231061689656 0.207138374846577 no 712 0.211788468150546 955 25236499 SGTC_1380 2291-0730 164 µM 0.799133518752325 0.207460566040141 no 713 0.212106497869134 1003 2999191 SGTC_1865 st057639 52.2 µM 0.798685839234663 0.207592070416709 no 714 0.212236299937639 1068 688818 SGTC_1835 st008666 49.2 µM 0.797585696226658 0.207915442962859 no 715 0.212555477175872 938 690455 SGTC_409 arachidonic acid 100 µM 0.7968754129787 0.20812437928187 no 716 0.212761695825489 1069 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2319 6033012 152.6 µM 0.795878780713267 0.208417756610204 no 717 0.213051247875113 972 847246 SGTC_1284 0929-0043 16 µM 0.795429564385093 0.208550071533374 no 718 0.213181834037127 1035 1239883 SGTC_3140 9094243 49.47 µM 0.79368065777644 0.209065676717581 no 719 0.213690681648843 1126 19291112 SGTC_733 4069-0007 56.1 µM 0.793279396329707 0.209184080693519 no 720 0.213807529116541 1075 5717425 YNL287W SEC21 SGTC_1992 st073643 23.3 µM 0.792098860875255 0.209532661207879 no 721 0.214151517128362 1071 3161292 SGTC_1777 st045864 34.765 µM 0.791273910651737 0.209776449608158 no 722 0.214392084658059 1050 4691462 SGTC_638 3970-0837 4.09 µM 0.791138346974139 0.209816527187139 no 723 0.214431632035129 1038 4118451 YLR208W SEC13 SGTC_1485 3909-9022 254 µM 0.786594314933142 0.21116251132453 no 724 0.215759694159641 1104 714516 SGTC_1093 fluphenazine 7.97 µM 0.786013579017528 0.211334894559605 no 725 0.215929765947971 1132 6602611 An atypical antipsychotic. SGTC_1645 Cervolide 78 µM 0.784851498715895 0.211680089053742 no 726 0.216270320849344 1005 23173 A fragrance. SGTC_1180 1193-0155 285 µM 0.784804373658268 0.211694094452129 no 727 0.216284137699743 1045 2921347 SGTC_2089 5281248 129.67 µM 0.78463072877025 0.211745705771849 no 728 0.216335053993685 1032 2737878 SGTC_3273 9137859 49.47 µM 0.78395599175245 0.211946323270346 no 729 0.216532966774699 1124 2377234 SGTC_2450 5739737 12.93 µM 0.78388437083253 0.211967624624922 no 730 0.21655398065635 1024 2262825 SGTC_3 0833-0587 95.581 µM 0.783184217526904 0.21217592880289 no 731 0.216759470741008 1034 5382644 SGTC_900 1112-0045 141 µM 0.779534606710573 0.213263668716252 no 732 0.217832430029784 976 56211 YIL048W NEO1 SGTC_870 0573-2213 57.6 µM 0.779190280295837 0.213366460286757 no 733 0.217933817411547 1083 3916321 SGTC_1174 0739-0097 51.1 µM 0.776327610386511 0.21422216910088 no 734 0.218777787325032 1057 728447 SGTC_3269 9137823 49.47 µM 0.776209316467784 0.214257572403366 no 735 0.218812703055837 983 17682936 SGTC_2945 9067681 61.76 µM 0.774993315174191 0.214621697613273 no 736 0.219171804839419 1120 16456930 SGTC_3290 9121031 71.43 µM 0.774646452462749 0.214725629726994 no 737 0.219274300206261 1035 17014854 SGTC_40 0327-0103 19.753 µM 0.772899549867428 0.215249506763111 no 738 0.219790915580313 1026 409036 SGTC_3107 9121808 49.47 µM 0.772618210880066 0.215333946553974 no 739 0.219874181856945 1045 662681 SGTC_902 1120-0002 2.07 µM 0.772277659527761 0.215436183781356 no 740 0.219974997092155 1097 3280475 SGTC_389 tpck 16.7 µM 0.771651059180293 0.215624369586001 no 741 0.220160562218746 1060 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1252 0493-0875 34.8 µM 0.770855648907591 0.215863391022938 no 742 0.220396248978892 1064 3960963 SGTC_1249 0481-0015 10.2 µM 0.770058131981726 0.216103199594208 no 743 0.220632705087658 1065 4227577 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.7698953357953 0.216152170390258 no 744 0.22068099044767 1084 2333 A French combination drug. SGTC_776 4476-4378 112 µM 0.769246802324386 0.216347319826431 no 745 0.220873405594282 1025 2892008 SGTC_1111 tnp00062 510.699 nM 0.7630259954539 0.218224389388832 no 746 0.22272394641193 1134 676306 SGTC_2663 amphotericin b 100 µM 0.762249421767708 0.218459370216679 no 747 0.222955577241484 1090 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2939 9044578 71.43 µM 0.762165814477983 0.21848467735172 no 748 0.222980523203201 1086 2653634 SGTC_944 3370-0224 231 µM 0.762049115456269 0.218520003863359 no 749 0.223015345424596 1117 4580514 SGTC_2165 5727197 32.143 µM 0.758979099747399 0.219450523471956 no 750 0.22393252969821 1153 1361712 SGTC_353 1988-1175 58.3 µM 0.758507711063006 0.219593602386012 no 751 0.224073549267664 1003 2788357 SGTC_824 1304-0008 100 µM 0.758086022801936 0.219721641296931 no 752 0.224199743307069 1083 768245 SGTC_1909 st060837 51.5 µM 0.757886130554178 0.219782350359552 no 753 0.224259576973122 1046 678937 SGTC_237 nikkomycin 200 µM 0.756718547340877 0.220137148147679 no 754 0.224609250272446 1112 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_893 0958-0369 48.9 µM 0.75653644318763 0.22019251440225 no 755 0.224663815546653 1118 6819948 SGTC_961 1252-1571 372 µM 0.756474317976106 0.220211404542141 no 756 0.224682432323599 1069 6813498 SGTC_295 k015-0027 31 µM 0.756100371946142 0.220325128297328 no 757 0.224794509495889 1083 3887424 SGTC_198 3454-2873 16.191 µM 0.756087147404163 0.220329150736193 no 758 0.224798473667565 1109 710957 SGTC_523 1934-0222 13.7 µM 0.755369233840861 0.220547577870554 no 759 0.225013733987253 1121 1361595 SGTC_2009 4012297 12.05 µM 0.755319788056259 0.220562626449291 no 760 0.225028564186782 1053 45595307 SGTC_2580 diallyl disulphide 81.36 µM 0.754225301917559 0.220895878469711 no 761 0.225356973553797 1071 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3040 9091894 49.47 µM 0.753465896828817 0.221127273422258 no 762 0.225584998539953 1035 25236966 SGTC_375 3970-0961 9.27 µM 0.752447171224753 0.221437902484904 no 763 0.225891094116347 1078 2898222 SGTC_2796 7949634 45.45 µM 0.751651851165862 0.221680584208605 no 764 0.226130226390013 1067 2971588 SGTC_3174 9107204 49.47 µM 0.750888168772674 0.221913755059878 no 765 0.22635998061011 1104 3938802 SGTC_2679 rapamycin 1 nM 0.749943037036622 0.22220252065228 no 766 0.226644506423805 1139 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_975 1335-0046 28.5 µM 0.749841933043572 0.222233423591996 no 767 0.226674955075637 1119 16486740 SGTC_2010 4012422 159 µM 0.746969094437039 0.223112545330114 no 768 0.227541108268935 1086 952393 SGTC_3322 9139058 2.11 µM 0.744926671650152 0.223738752690648 no 769 0.228158025143944 1103 4908926 YPR165W RHO1 SGTC_1864 st057645 30.4 µM 0.744290496904255 0.223934007925385 no 770 0.228350374594112 1155 688666 SGTC_545 4218-0007 221 µM 0.741095624898332 0.224916043305683 no 771 0.229317731090733 1086 2840508 SGTC_1070 indatraline 8.81 µM 0.740304807668054 0.225159499997028 no 772 0.22955753221461 1114 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1167 k781-0610 148 µM 0.739671455511539 0.225354587958633 no 773 0.229749686157882 1126 4525169 SGTC_2470 5664817 21.68 µM 0.739049923670401 0.225546127987169 no 774 0.229938341447852 1163 2859561 SGTC_482 fipronil 114 µM 0.73798504327076 0.225874510632599 no 775 0.23026176901322 1149 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2258 7960471 200 µM 0.736987077634798 0.226182503692126 no 776 0.230565103904222 1092 2974708 SGTC_2278 7948257 134.34 µM 0.735859638781732 0.226530740199985 no 777 0.230908061083937 1117 1247028 SGTC_1433 4060-0023 7.6 µM 0.734410574421027 0.226978762662028 no 778 0.231349271975264 1147 3840627 SGTC_1608 st001473 40.5 µM 0.73154973859789 0.227864742746842 no 779 0.232221717713532 1103 7292267 SGTC_1518 st038567 90.8 µM 0.731211873998512 0.227969505283338 no 780 0.232324874264263 1154 77966 SGTC_91 0417-1751 58.384 µM 0.730703311680851 0.228127247569317 no 781 0.232480196161596 1269 6795624 SGTC_332 4112-0506 40.9 µM 0.729584509761057 0.228474485622727 no 782 0.232822096762618 1134 2790355 SGTC_2259 7964009 200 µM 0.728817821775986 0.228712610852794 no 783 0.233056554232123 1143 313134 SGTC_1104 tacrolimus 29.8 µM 0.728539889009864 0.228798968250427 no 784 0.233141579991672 1185 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2844 9010103 25.97 µM 0.727145153866238 0.229232607251619 no 785 0.233568520157142 1130 2480525 SGTC_2786 7743617 45.45 µM 0.726670422616984 0.229380311649441 no 786 0.233713938229134 1076 583674 SGTC_936 3005-4620 401 µM 0.726594393840369 0.229403971640063 no 787 0.233737231768615 1166 777207 SGTC_1766 st045414 44.774 µM 0.726016212889707 0.229583945047499 no 788 0.23391441575193 1206 253960 SGTC_2178 5812956 200 µM 0.725789156949381 0.229654643562738 no 789 0.233984017559099 1155 5403383 SGTC_3008 9078912 71.4286 µM 0.725349427522253 0.229791596993134 no 790 0.234118844988971 1144 16648731 SGTC_188 3229-0966 278.469 µM 0.724990684167306 0.229903361231358 no 791 0.234228872771617 1248 5722370 SGTC_536 3852-0578 10.6 µM 0.724923637612398 0.229924252538691 no 792 0.234249439347983 1153 2869208 SGTC_1071 trifluoperazine 6.31 µM 0.721041879556851 0.231135595433772 no 793 0.235441874175894 1173 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_49 0717-0965 32.132 µM 0.719611569113785 0.231582834905289 no 794 0.235882093437064 1259 5889349 YGL099W LSG1 SGTC_2628 lathosterol 100 µM 0.718353008590643 0.231976769039838 no 795 0.236269826675741 1223 6710616 SGTC_1967 st070177 51.4 µM 0.717804464645935 0.232148582024334 no 796 0.23643893006848 1183 5729214 SGTC_2841 9004761 38.96 µM 0.715963820107396 0.232725619410983 no 797 0.23700684466168 1098 2991039 SGTC_325 2810-4341 181 µM 0.715142113259106 0.232983479552161 no 798 0.237260616890606 1173 774970 SGTC_2038 4100038 30.985 µM 0.713209059141428 0.233590717270196 no 799 0.237858200664957 1145 3596803 SGTC_896 0964-0007 44.5 µM 0.711982760989425 0.233976393535372 no 800 0.238237725580479 1170 6756758 SGTC_3009 9080819 71.4286 µM 0.711320679366577 0.234184767723259 no 801 0.23844276991425 1186 17027216 SGTC_1588 farnesol 29.9 µM 0.711046970543576 0.234270940967991 no 802 0.238527564788887 1176 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2099 5377090 177.372 µM 0.710916626978147 0.23431198391388 no 803 0.23856795097032 1157 2243829 SGTC_3226 9131256 49.47 µM 0.710849350386274 0.234333169712127 no 804 0.238588797688062 1085 17178073 SGTC_432 NS 1619 61.3 µM 0.710458239488133 0.234456353850534 no 805 0.238710009339409 1141 4552 A K+/calcium channel activator. SGTC_1927 st060202 13.8 µM 0.709333648344586 0.234810754182234 no 806 0.239058726140879 1155 688887 SGTC_553 k007-0256 45.7 µM 0.708366341789838 0.235115825055379 no 807 0.23935889427092 1206 6287000 SGTC_2735 sertaconazole 140 nM 0.706911265477689 0.235575141679064 no 808 0.239810811350611 1221 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1429 4049-0205 9.46 µM 0.706201683601749 0.235799311256364 no 809 0.240031361768183 1216 22774478 SGTC_3000 9075062 71.4286 µM 0.704580891654946 0.236311789205178 no 810 0.240535546706715 1147 17057871 SGTC_1197 1601-0112 267 µM 0.702620893688162 0.236932339009125 no 811 0.241146019051205 1194 7350313 SGTC_783 0848-0141 92.7 µM 0.702234913642256 0.237054648623787 no 812 0.2412663378236 1180 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2761 levamisole 97.89 µM 0.702002310604611 0.237128372781527 no 813 0.241338861239847 1173 26879 An alkaline phosphatase inhibitor. SGTC_2698 st077697 67.5 µM 0.700471741216128 0.237613804897678 no 814 0.241816373496713 1144 3154499 SGTC_2018 5133068 143 µM 0.698883629532773 0.238118062899177 no 815 0.242312379460467 1189 785362 SGTC_2276 7947513 42.08 µM 0.698484947987225 0.238244744485115 no 816 0.242436983940681 1104 2105100 SGTC_2514 salinomycin 42.74 µM 0.69841215348312 0.238267879020078 no 817 0.242459738982448 1231 23682228 A polyether potassium ionophore. SGTC_1253 0550-0034 176 µM 0.697887725106348 0.238434581900621 no 818 0.242623705731128 1151 5969915 SGTC_1841 st054148 70 µM 0.696687055351952 0.238816485643918 no 819 0.242999330763845 1149 675442 SGTC_674 0498-0004 451 µM 0.696307928293557 0.238937146177985 no 820 0.243118004555329 1165 4231473 SGTC_2649 anisomycin 9.56 µM 0.695201322893229 0.239289523694155 no 821 0.243464571707605 1168 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3353 9151644 39.2805 µM 0.692600995974586 0.240118664740394 no 822 0.244279992561598 1197 4909158 SGTC_2507 purpurin 79.67 µM 0.692053597335853 0.240293407765151 no 823 0.244451835382537 1193 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_319 1348-1596 45.5 µM 0.689165388414473 0.241216540833093 no 824 0.245359597526016 1252 5380505 SGTC_3267 9137951 49.47 µM 0.687953607100403 0.241604425181298 no 825 0.245740998428749 1204 16643986 SGTC_3242 9133940 49.47 µM 0.687815698679092 0.241648590340877 no 826 0.245784424443064 1252 17248444 SGTC_1337 1486-1011 40.3 µM 0.686389207626067 0.242105681007576 no 827 0.246233854136073 1228 X1337 SGTC_2148 5546263 113.568 µM 0.683221880472588 0.243122261851226 no 828 0.247233324267716 1198 792097 SGTC_3110 9122132 49.47 µM 0.68234580000036 0.243403854364891 no 829 0.247510159503756 1292 918317 SGTC_3318 9139014 38.6185 µM 0.68128264809281 0.243745812515029 no 830 0.247846330314544 1208 16643984 SGTC_1266 0828-0227 32.9 µM 0.681230841063628 0.243762482643005 no 831 0.247862718028897 1180 3913820 SGTC_462 ag-879 158 µM 0.68111470601896 0.243799854056262 no 832 0.247899456225197 1225 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1999 st074831 12.5 µM 0.680508311088454 0.243995037756905 no 833 0.24809133058423 1209 17112523 SGTC_2658 polymyxin b sulfate 77.05 µM 0.679911978794231 0.244187064721753 no 834 0.248280098177004 1195 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2973 9094665 17.96 µM 0.678689065233871 0.24458111398473 no 835 0.248667448026472 1236 25237061 YIL048W NEO1 SGTC_1631 benzylvanillin 81.9 µM 0.678359273114782 0.244687438760559 no 836 0.248771962592977 1226 75506 SGTC_860 0443-0016 25.1 µM 0.675631890253482 0.245567698526495 no 837 0.249637194489617 1244 5337942 SGTC_2585 alliin 100 µM 0.673984167472629 0.246100322332749 no 838 0.250160689735097 1304 87310 A garlic compound which reacts with lipids. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.671559616459207 0.246885179993528 no 839 0.250932047243517 1197 6857784 SGTC_1060 3448-7350 82 µM 0.670487370719758 0.247232706194886 no 840 0.251273577312856 1199 570178 SGTC_2255 7941087 197.44 µM 0.670273637598745 0.247302010617177 no 841 0.251341684625901 1257 935561 SGTC_688 0527-0193 473 µM 0.669906013255792 0.247421239609335 no 842 0.251458853104404 1238 4007154 SGTC_244 nsc-207895 1.295 µM 0.668475758649015 0.247885396038143 no 843 0.251914975394189 1139 42640 SGTC_524 r073-0010 27.8 µM 0.667805105253256 0.248103201215031 no 844 0.252129003660686 1187 2772106 SGTC_874 0599-0792 117 µM 0.66777210453241 0.248113921349761 no 845 0.252139537786467 1264 765305 SGTC_668 1682-0499 62.6 µM 0.667592192421812 0.248172369329242 no 846 0.252196971426648 1259 682214 SGTC_1128 3448-9350 235 µM 0.666745568343303 0.248447510327803 no 847 0.252467333226609 1229 619386 SGTC_2832 7992762 51.95 µM 0.666601434109916 0.248494368128606 no 848 0.252513376410178 1147 2985177 SGTC_2488 5268135 45.7 µM 0.665311964778724 0.24891378190603 no 849 0.252925489708315 1247 1270356 YLR208W SEC13 SGTC_2524 avocatin b 10.57 µM 0.66375604003153 0.249420364337945 no 850 0.253423232783632 1186 6710748 SGTC_2774 tamoxifen 10.92 µM 0.663668369009746 0.24944892481873 no 851 0.253451294211 1284 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1058 3448-5425 97.3 µM 0.661545038018882 0.250141170205908 no 852 0.254131420769531 1184 7279705 SGTC_929 2805-0021 398 µM 0.660387467065407 0.250518988595636 no 853 0.254502606413249 1291 3098024 SGTC_3196 9111891 49.47 µM 0.660033785552409 0.250634486617855 no 854 0.254616074231343 1259 18891510 SGTC_1172 0370-0043 85 µM 0.659722130872926 0.250736283755002 no 855 0.25471608099127 1283 376585 SGTC_2957 9076800 11.52 µM 0.659626726197559 0.250767450579728 no 856 0.254746699475183 1195 16459615 SGTC_1055 3448-0672 86 µM 0.659423020339654 0.250834004128845 no 857 0.254812081803774 1235 748378 SGTC_2601 securinine 100 µM 0.658848479499899 0.25102176501432 no 858 0.254996536276519 1230 442872 A GABA receptor antagonist. SGTC_2777 climbazole 1.536 µM 0.65510339680117 0.252247484166624 no 859 0.256200592619323 1238 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2152 5568786 200 µM 0.654332409077701 0.252500210048919 no 860 0.256448835130745 1230 5399883 SGTC_1133 3473-0247 50 µM 0.653250649115516 0.252855030302695 no 861 0.256797351202298 1233 711311 SGTC_2003 4023581 200 µM 0.651867727670569 0.253309014305137 no 862 0.257243252759299 1287 16641307 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.65161307536149 0.253392657992017 no 863 0.257325405303214 1283 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_572 0960-0087 17.7 µM 0.651353411132517 0.253477962851395 no 864 0.257409188764314 1249 6796365 SGTC_377 3970-0964 33.1 µM 0.651097819984866 0.253561944357449 no 865 0.257491671841918 1266 16481235 SGTC_891 0929-0073 133 µM 0.650794071921261 0.253661768148422 no 866 0.25758971372561 1303 5603632 SGTC_442 cape 100 µM 0.65054083588565 0.253745007435918 no 867 0.257671466471522 1257 5281787 SGTC_56 0957-0365 83.25 µM 0.649790338421572 0.253991781950506 no 868 0.257913830314389 1232 6752360 SGTC_1030 k029-0042 36.7 µM 0.649393419435805 0.254122345595928 no 869 0.258042058176265 1301 6080581 SGTC_1768 st044301 37.178 µM 0.647217028532288 0.254838878960304 no 870 0.258745745950774 1269 3931349 SGTC_1717 st033143 58.0435 µM 0.645083245028432 0.255542410005037 no 871 0.259436620551696 1310 674616 SGTC_542 3381-0244 89.3 µM 0.645056496454364 0.255551235728103 no 872 0.259445287225421 1283 1112843 SGTC_102 gallobenzophenone 83.616 µM 0.644782980989021 0.255641491611035 no 873 0.259533916205813 1346 70837 SGTC_714 4296-0578 26.1 µM 0.644350763592136 0.255784150613385 no 874 0.259674002263428 1264 1589775 SGTC_2407 paclitaxel 400 µM 0.644023572209857 0.25589217203766 no 875 0.259780074270676 1396 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2025 5147754 141 µM 0.642986000981302 0.256234880993416 no 876 0.260116591765773 1271 315777 YLR208W SEC13 SGTC_590 k048-0076 22.4 µM 0.64095253412211 0.256907226867437 no 877 0.260776761201625 1311 6832814 SGTC_2244 6635614 200 µM 0.640802778118657 0.25695677848834 no 878 0.260825413872514 1235 836499 SGTC_632 0781-2353 4.65 µM 0.64048060423248 0.257063396999171 no 879 0.260930097423039 1311 6811515 YHR007C ERG11 SGTC_1956 st077085 54 µM 0.639112700486286 0.257516339892101 no 880 0.261374809154283 1284 24208685 SGTC_1637 st007924 17.4 µM 0.638625274489101 0.257677837433138 no 881 0.261533367580906 1265 683336 SGTC_1651 st011928 86.1 µM 0.637862705646516 0.257930602754616 no 882 0.261781528287503 1292 720198 SGTC_490 phenamil 164 µM 0.636515329523894 0.258377525790159 no 883 0.262220296317125 1236 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1534 6-azauridine 81.6 µM 0.633955293034322 0.259227790900002 no 884 0.263054999460461 1308 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2469 5655019 90.81 µM 0.633702810579219 0.259311726195003 no 885 0.263137395188658 1376 2788239 SGTC_1643 st009866 20.2 µM 0.632826319391648 0.259603215977565 no 886 0.263423533726959 1283 3156273 YOR207C RET1 SGTC_260 nsc-65238 3.989 µM 0.631730776941573 0.259967792135525 no 887 0.263781406758618 1247 3246252 SGTC_1857 st056007 79.3 µM 0.630358653279497 0.260424781555136 no 888 0.264229978057301 1299 619834 SGTC_829 1635-0120 117 µM 0.629781208490257 0.260617224696313 no 889 0.264418870966088 1309 285054 SGTC_4 0960-0234 25.671 µM 0.629355422037705 0.260759172031748 no 890 0.26455819762859 1305 6821112 SGTC_1087 pterostilbene 9.05 µM 0.628952094889936 0.260893668634103 no 891 0.264690209552414 1360 5281727 Similar to reservatol, lowers cholesterol. SGTC_46 0329-0187a 2.197 µM 0.628457755564009 0.261058563516074 no 892 0.26485205610743 1331 46494817 SGTC_2301 7769476 200 µM 0.62823957240927 0.261131359076517 no 893 0.264923505207799 1324 977820 SGTC_1306 1185-0270 9.02 µM 0.627709588112623 0.261308228743805 no 894 0.265097101561872 1278 1548076 SGTC_2321 7390090 138.78 µM 0.624280318848812 0.262454151402145 no 895 0.266221753414895 1244 649046 SGTC_1885 st057546 99.9 µM 0.623161260569769 0.262828651263861 no 896 0.266589278072334 1365 702008 SGTC_289 k017-0060 526 µM 0.622233829530019 0.263139228830789 no 897 0.26689406220662 1293 5512909 SGTC_2544 sphondin 68.51 µM 0.620593071141732 0.263689143981397 no 898 0.267433699861917 1342 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2821 7996764 71.43 µM 0.620570092414476 0.263696849671908 no 899 0.267441261362067 1367 2987135 SGTC_2256 7954252 200 µM 0.619612669664621 0.26401801404786 no 900 0.26775641171053 1264 2972920 SGTC_201 4262-0159 12.803 µM 0.618967026654566 0.264234705390917 no 901 0.267969040576593 1286 1341029 SGTC_3081 9117243 49.47 µM 0.618223710959263 0.26448428984725 no 902 0.268213941120439 1393 45595589 SGTC_1022 4477-0945 21.3 µM 0.617235647370805 0.264816239365561 no 903 0.268539653108882 1305 4648966 SGTC_897 1000-0139 31.4 µM 0.616374036842638 0.265105878530449 no 904 0.26882384244318 1313 6151020 SGTC_789 1309-1135 70.6 µM 0.613478490792526 0.266080423423832 no 905 0.26978000036075 1315 3092424 SGTC_1336 1486-0901 104 µM 0.613160936601012 0.266187411939834 no 906 0.269884965618231 1347 5006114 SGTC_858 0438-0351 2.77 µM 0.61273086414889 0.266332344169537 no 907 0.270027155564197 1313 2799119 SGTC_2646 retinol 96.75 µM 0.612267817647999 0.266488433117088 no 908 0.270180289237679 1325 445354 A vitamin A analog and teratogen. SGTC_121 0557-0495 61.343 µM 0.612071756000409 0.266554537734018 no 909 0.27024514168707 1414 3104427 SGTC_2201 6605497 169.863 µM 0.611946542241851 0.266596759444889 no 910 0.270286563441508 1331 670741 SGTC_1054 3429-0080 167 µM 0.611749255642067 0.266663290766631 no 911 0.270351833932351 1347 1162877 SGTC_1357 1503-1303 39.5 µM 0.610897621934326 0.266950585052727 no 912 0.270633679640888 1325 292895 SGTC_1049 3226-0134 66 µM 0.609625485161951 0.267380024897012 no 913 0.271054962762766 1336 5702385 SGTC_2930 9013230 14.89 µM 0.608907702078468 0.26762248324074 no 914 0.271292809373577 1333 2995857 SGTC_1801 st050089 28.441 µM 0.607859344278429 0.267976804707249 no 915 0.271640382959687 1338 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2355 9061122 103.12 µM 0.607564564379518 0.268076476243543 no 916 0.271738154499162 1318 5302957 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.607455305149201 0.268113423920497 no 917 0.271774397657374 1339 5282362 SGTC_573 3702-0553 84.7 µM 0.605253883365463 0.268858413961429 no 918 0.272505159118599 1309 1222756 SGTC_256 clotrimazole 625 nM 0.605096464284399 0.268911726443705 no 919 0.27255745170062 1328 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1210 3013-0140 750 nM 0.603531354538177 0.269442064375035 no 920 0.273077631737981 1385 905973 SGTC_629 3448-6466 76.7 µM 0.600719836006081 0.270396063291228 no 921 0.274013302495537 1327 573744 SGTC_2974 9094440 9.66 µM 0.599797474082512 0.270709404682289 no 922 0.274320608468545 1448 25236134 SGTC_2106 5357045 167.29 µM 0.598921912868911 0.271007014754376 no 923 0.27461247905092 1391 668842 SGTC_2327 6189656 200 µM 0.598526996765435 0.271141303203477 no 924 0.274744175457345 1408 5349088 SGTC_116 0155-0182 31.788 µM 0.597142242898489 0.27161244103854 no 925 0.275206208305543 1323 771486 SGTC_1042 0350-0096 82 µM 0.596567998039974 0.271807937120401 no 926 0.275397921279974 1328 3122515 SGTC_1292 0kpi-0043 232 µM 0.595395259020993 0.272207402112656 no 927 0.27578964692623 1325 3333905 SGTC_2459 5811157 9.22 µM 0.594717333883814 0.272438453813416 no 928 0.276016216557648 1314 2870684 YBR192W RIM2 SGTC_935 2996-0153 430 µM 0.593511897886858 0.272849533165326 no 929 0.276419311427336 1359 23738523 SGTC_785 1270-0111 65.3 µM 0.593457292891697 0.272868161913191 no 930 0.27643757803818 1326 6741994 SGTC_2372 9071633 200 µM 0.592398301718884 0.273229566369806 no 931 0.276791951651078 1370 21321366 SGTC_1789 tunicamycin 25 nM 0.591291307114459 0.273607606403265 no 932 0.277162626535466 1333 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_899 1083-0020 478 µM 0.588719694072206 0.274486813224122 no 933 0.27802466221873 1411 767123 SGTC_1154 4088-0362 150 µM 0.588423894589004 0.274588033214483 no 934 0.278123901596518 1341 6618304 SGTC_476 mead acid 10 µM 0.587211930316948 0.275002948936451 no 935 0.278530690410143 1385 5312531 An omega 9 fatty acid. SGTC_2525 harmine 47.85 µM 0.587185877144447 0.275011871624825 no 936 0.27853943818824 1381 5280953 A monoamine oxidase inhibitor SGTC_10 0279-0212 42.575 µM 0.585649009788857 0.275538470033729 no 937 0.279055703153465 1356 39851 YBR002C RER2 SGTC_2211 7117706 200 µM 0.583695785432328 0.276208445508659 no 938 0.279712501642791 1356 822771 SGTC_76 0433-0009 400.328 µM 0.583516160622212 0.276270098732602 no 939 0.279772940594161 1372 2841569 SGTC_1076 itraconazole 331 nM 0.58342064294775 0.276302886333076 no 940 0.279805082320818 1366 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2919 7978188 46.38 µM 0.58311163963751 0.276408968543713 no 941 0.279909074298446 1360 2980291 SGTC_1578 josamycin 24.2 µM 0.582973193983315 0.276456504031427 no 942 0.279955672879748 1301 5282165 A P450 substrate. SGTC_1813 st051246 8.6015 µM 0.580676276766531 0.277245737861229 no 943 0.280729326668654 1345 5291959 SGTC_500 h-89 112 µM 0.579555484572141 0.277631248120632 no 944 0.281107209903451 1473 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_577 r071-0003 38.6 µM 0.57948882293991 0.277654185457415 no 945 0.281129693096665 1380 4568517 YMR134W ERG29 SGTC_2752 diclazuril 33.15 µM 0.578638609818169 0.277946813088626 no 946 0.281416523497285 1392 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_565 1418-0001 44.5 µM 0.578396269519745 0.278030249693778 no 947 0.28149830598887 1408 2862145 SGTC_2865 9030313 51.95 µM 0.576655916817858 0.278629803545054 no 948 0.282085958768381 1311 42562754 SGTC_2288 7946289 167.31 µM 0.576237193982111 0.278774148031243 no 949 0.282227434098647 1467 1246052 SGTC_1407 3909-7909 12.3 µM 0.574872026382552 0.27924500888601 no 950 0.282688925002532 1351 4411780 SGTC_1488 4013-0813 75.9 µM 0.574102447879679 0.279510614961862 no 951 0.282949238489428 1351 2910057 SGTC_1021 4476-0760 85.3 µM 0.571402379205086 0.28044346376373 no 952 0.283863458345954 1344 746768 SGTC_3232 9132874 49.47 µM 0.570494282188931 0.280757541241792 no 953 0.284171249556219 1341 3784940 SGTC_3218 9131285 49.47 µM 0.569673149838546 0.281041687199599 no 954 0.28444970220678 1486 17156417 SGTC_2096 5468907 200 µM 0.567668824443973 0.281735850101 no 955 0.2851299321068 1425 759785 SGTC_647 0140-0236 81 µM 0.565181802124768 0.282598333969091 no 956 0.285975056554678 1421 990837 SGTC_3139 9095020 49.47 µM 0.563842276293069 0.283063398485039 no 957 0.286430738677809 1231 25236292 SGTC_2296 7971656 126.45 µM 0.56280036530112 0.283425389103867 no 958 0.286785415771021 1391 666570 SGTC_401 neomycin 50 µM 0.561730943722565 0.283797168335909 no 959 0.2871496740966 1385 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1844 rapamycin 4 nM 0.560318868343302 0.284288426902026 no 960 0.287630979854107 1385 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3310 9130229 44.1445 µM 0.559736736598636 0.284491067782312 no 961 0.287829510341031 1446 7761258 SGTC_2693 st077581 40.7 µM 0.559442756159376 0.284593429000572 no 962 0.287929794159856 1400 25238761 SGTC_1770 st043884 66.3 µM 0.559206956420692 0.284675544955486 no 963 0.288010243059648 1392 670149 SGTC_27 0485-0001 32.618 µM 0.55893654554446 0.284769727968335 no 964 0.288102513461747 1364 2054479 SGTC_356 1634-0012 32.5 µM 0.557900600037198 0.285130681133084 no 965 0.288456130886279 1416 735457 SGTC_3213 9129884 49.47 µM 0.557741151277803 0.285186257019888 no 966 0.288510576484988 1309 17190742 SGTC_1300 1094-0077 113 µM 0.557448418067957 0.285288302656819 no 967 0.28861054618498 1371 5532636 SGTC_1171 0368-0077 21.4 µM 0.557351515433742 0.285322086362941 no 968 0.288643642462303 1373 3239779 SGTC_3211 9128781 49.47 µM 0.557131986938738 0.285398628855342 no 969 0.288718627179544 1391 17194361 SGTC_23 0213-0011 39.996 µM 0.556116915149398 0.285752678671188 no 970 0.289065466168956 1459 627608 SGTC_1098 clofazimine 15.1 µM 0.55558720838374 0.285937519540151 no 971 0.289246538991079 1455 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2472 5377652 49.4 µM 0.554331023191151 0.286376091705772 no 972 0.289676161266627 1375 1610903 SGTC_838 0109-0203 71.4 µM 0.551418337167459 0.287394224957822 no 973 0.290673466606772 1398 759422 SGTC_2200 6600604 21.907 µM 0.551270145304159 0.287446071360009 no 974 0.290724250489638 1358 2904777 SGTC_1568 digitonin 820 nM 0.550607947070346 0.287677802050421 no 975 0.290951229942129 1524 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1155 4088-0394 48.2 µM 0.550170909111123 0.287830788144041 no 976 0.291101077313894 1372 2326248 SGTC_567 1080-0542 68.4 µM 0.548995746656385 0.288242346803511 no 977 0.29150418437455 1391 5950415 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.548236550720742 0.288508375545568 no 978 0.291764743942945 1456 5024745 SGTC_2383 9036125 200 µM 0.546705605363427 0.289045183492842 no 979 0.292290501302105 1414 79580 SGTC_2843 9000894 45.46 µM 0.545818162573369 0.28935656979308 no 980 0.292595468577847 1314 2242070 SGTC_179 1273-0063 6.77 µM 0.545733905968028 0.289386141977218 no 981 0.292624430811534 1383 3108139 SGTC_727 3032-0951 202 µM 0.544491509891623 0.289822359957111 no 982 0.293051644616949 1425 3652836 SGTC_172 1112-0046 2.638 µM 0.541237570710695 0.290966310811594 no 983 0.294171922225247 1431 2802135 YIL048W NEO1 SGTC_3038 9091290 49.47 µM 0.54118331990363 0.290985401026835 no 984 0.294190616642987 1468 25236843 SGTC_20 0481-0013 4.944 µM 0.541158159389452 0.290994254911847 no 985 0.294199286952158 1397 182045 SGTC_2890 9046729 58.44 µM 0.540211970490842 0.291327306358863 no 986 0.29452542915823 1364 903329 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.538490482074381 0.291933713286671 no 987 0.295119237173555 1444 368090 SGTC_1410 3909-8106 77.9 µM 0.537287855958259 0.292357695620259 no 988 0.295534396314819 1470 1039210 SGTC_2130 NSC 7 2.4545 µM 0.537285239858218 0.292358618230739 no 989 0.295535299712633 1475 21448 SGTC_3037 9091026 49.47 µM 0.537193803389381 0.29239086564798 no 990 0.295566875566684 1442 25236398 YIL048W NEO1 SGTC_841 0251-0215 91.2 µM 0.537051590321695 0.292441024021983 no 991 0.295615989240254 1464 3888614 SGTC_265 mycophenolic acid 32.932 µM 0.535968490767956 0.292823163074258 no 992 0.295990163673225 1485 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1203 3992-3522 103 µM 0.534846395265641 0.293219304989731 no 993 0.296378039038592 1659 5322312 SGTC_2695 st077686 51.995 µM 0.532392194957316 0.294086594823676 no 994 0.297227194905611 1392 2876092 SGTC_546 peri-Naphthalide 147 µM 0.532220453987747 0.2941473307267 no 995 0.297286659067219 1459 223824 A penicillin ester. SGTC_3070 9117005 49.47 µM 0.531719810823508 0.294324415401164 no 996 0.297460034426119 1499 8779016 SGTC_486 niguldipine 82 µM 0.531585314481556 0.294371997076498 no 997 0.297506619083392 1437 1236 A calcium channel blocker. SGTC_2682 pyrogallin 40.03 µM 0.529650459813261 0.295056896340002 no 998 0.298177150917305 1454 822798 An ATP competetive kinase inhibitor. SGTC_1064 honokiol 6.76 µM 0.528568566137627 0.295440184404355 no 999 0.298552385423879 1417 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2981 9013952 38.96 µM 0.528343463192287 0.295519961562356 no 1000 0.298630485139683 1333 2996344 SGTC_2377 9073351 62.6 µM 0.527661140606535 0.295761839230308 no 1001 0.298867274455518 1406 7337946 YHR072W ERG7 SGTC_1597 7-benzyloxygramine 47.5 µM 0.527550964419937 0.295800904297766 no 1002 0.298905517365146 1426 260807 SGTC_710 3448-4187 58 µM 0.527280278950433 0.295896891055725 no 1003 0.298999483585832 1455 3946412 SGTC_1338 1486-1223 76 µM 0.526998705897857 0.295996753794302 no 1004 0.299097243573365 1514 3444526 SGTC_2359 9039622 200 µM 0.526100835581863 0.29631529588784 no 1005 0.299409074068577 1444 6463596 SGTC_3172 9105863 49.47 µM 0.525905533029213 0.296384605193115 no 1006 0.299476922190014 1455 2348785 SGTC_2213 7173844 200 µM 0.524274317439004 0.296963783818086 no 1007 0.300043878614733 1417 892728 SGTC_659 k018-0002 107 µM 0.523121984616335 0.297373242373688 no 1008 0.300444683708241 1486 6797879 YHR007C ERG11 SGTC_2139 5578692 56.4705 µM 0.52176065794912 0.297857294755155 no 1009 0.300918492542649 1469 650991 YMR113W FOL3 SGTC_2144 5628481 200 µM 0.520870761140822 0.298173913006203 no 1010 0.301228402538243 1452 2818399 SGTC_3027 9089541 49.47 µM 0.520260307954358 0.298391196034522 no 1011 0.301441078314231 1436 9943819 SGTC_732 3970-1727 52.7 µM 0.519432868749687 0.298685827450558 no 1012 0.3017294576767 1567 1275699 SGTC_1037 k284-1091 78.7 µM 0.518190823905892 0.299128338167644 no 1013 0.302162568189728 1422 3334711 SGTC_2508 celastrol 40.54 µM 0.517479981847673 0.299381727918642 no 1014 0.30241056973174 1411 122724 Celastrol is a natural product and antioxidant. SGTC_2911 7942208 15.64 µM 0.514326665722551 0.300506944003975 no 1015 0.303511810681677 1419 1243384 SGTC_393 acivicin 6.25 µM 0.512986016981649 0.300985913419199 no 1016 0.303980550991152 1448 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1791 st048313 56.1 µM 0.510892898838073 0.301734402543369 no 1017 0.304713026932417 1525 1204976 SGTC_2464 5717415 7.67 µM 0.510817710593619 0.301761305067168 no 1018 0.304739353267982 1386 5285744 SGTC_275 trichlorophene 5.69 µM 0.510552446419765 0.30185622579962 no 1019 0.304832240672153 1504 62616 SGTC_2387 9077560 195.08 µM 0.509814879616201 0.302120223306646 no 1020 0.30509058012536 1418 5303272 SGTC_1422 4031-0024 15.5 µM 0.507546642053325 0.302932743015171 no 1021 0.305885659263532 1426 782427 SGTC_1163 k060-0048 49.9 µM 0.506788569724548 0.303204514797723 no 1022 0.306151588637045 1464 6809982 SGTC_2328 6201408 200 µM 0.506555963415873 0.303287926887496 no 1023 0.306233206686712 1450 2890418 SGTC_3221 9128209 49.47 µM 0.505091668374578 0.303813255088743 no 1024 0.306747226462549 1496 16460723 SGTC_2177 5811945 192 µM 0.504919633886424 0.303875000552138 no 1025 0.306807641683837 1544 5343475 SGTC_2917 7979103 53.79 µM 0.504258432571329 0.304112366565784 no 1026 0.307039891773066 1563 2980565 SGTC_1510 1123-0200 71.5 µM 0.50380522884052 0.304275110810641 no 1027 0.307199126467335 1591 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1290 0986-0249 10.2 µM 0.503209739140848 0.304489008507931 no 1028 0.307408409101347 1457 53329 SGTC_2537 larixol 68.93 µM 0.501871323124204 0.304970006606954 no 1029 0.307879019246937 1517 6708759 SGTC_566 0958-0068 16.5 µM 0.499295263586141 0.305896735857174 no 1030 0.308785695680018 1492 6815365 SGTC_2332 7982454 138.89 µM 0.499162886314962 0.305944391818058 no 1031 0.308832319081488 1469 2981748 SGTC_309 k408-0051 1.48 µM 0.497864372545416 0.306412032252961 no 1032 0.30928982010865 1470 3640463 SGTC_2140 5586273 200 µM 0.491453724063137 0.30872534381643 no 1033 0.311552787188684 1481 854421 SGTC_347 4534-1311 26.2 µM 0.488771228253347 0.309695598797243 no 1034 0.312501834861178 1469 2862016 SGTC_1778 st046819 58.9 µM 0.486222758562279 0.310618606762561 no 1035 0.313404618514433 1521 671715 SGTC_1994 st072947 40.9 µM 0.485818675738315 0.310765067751681 no 1036 0.313547865922207 1528 5286565 YDL195W SEC31 SGTC_2731 amoxapine 43.43 µM 0.482338148674181 0.312027834553592 no 1037 0.314782875670334 1582 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3045 9092950 49.47 µM 0.482298795453248 0.312042124933774 no 1038 0.314796851421069 1621 44120432 SGTC_2600 tangeritin 87.95 µM 0.481155147229454 0.312457542712109 no 1039 0.315203118029644 1435 68077 A bioactive flavone. SGTC_1373 2887-0003 58.5 µM 0.480820237730624 0.312579240106201 no 1040 0.315322132754724 1514 776948 SGTC_271 rotenone 740 µM 0.480644904961774 0.312642959622322 no 1041 0.315384447324786 1540 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1856 st057054 55.7 µM 0.480247241893502 0.312787499271615 no 1042 0.315525799197328 1613 1266018 SGTC_1925 st057770 10.1 µM 0.479985827647353 0.312882531885291 no 1043 0.315618735265732 1419 5989122 SGTC_683 panaxydol 45 µM 0.478986670174879 0.313245872808596 no 1044 0.315974055801464 1552 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2057 5236571 38.335 µM 0.477466753261344 0.313798934230478 no 1045 0.316514894969848 1601 54684039 YBR257W POP4 SGTC_3169 9102970 49.47 µM 0.475871731506351 0.314379774740778 no 1046 0.31708288124569 1552 17027839 SGTC_313 3474-0040 5.03 µM 0.4756322250107 0.314467032778363 no 1047 0.31716820663272 1479 1043375 YIL048W NEO1 SGTC_1906 st060206 94.7 µM 0.4756231303985 0.314470346370942 no 1048 0.317171446825394 1585 5133468 SGTC_1238 0333-0287 48.8 µM 0.474700930457719 0.314806424500197 no 1049 0.317500077324745 1497 7226 SGTC_2994 9053520 71.4286 µM 0.474360832557961 0.314930405417269 no 1050 0.31762130921997 1615 4647384 SGTC_576 1073-0113 22.7 µM 0.474005511079277 0.315059958290401 no 1051 0.317747988631451 1601 5439563 SGTC_1659 st012954 42.1 µM 0.473689104414809 0.31517534168389 no 1052 0.31786081207238 1547 24207262 SGTC_1131 3454-3128 32.3 µM 0.470616297556247 0.316296832674931 no 1053 0.318957383583781 1623 710982 SGTC_507 nimesulide 162 µM 0.470486300720289 0.316344315358091 no 1054 0.319003809707642 1591 4495 A COX2 inhibitor. SGTC_995 3931-2021 34.6 µM 0.470343407388415 0.316396512112791 no 1055 0.31905484486829 1563 730143 SGTC_1860 st056228 74.6 µM 0.470234589742484 0.316436263992619 no 1056 0.319093712005954 1487 688679 SGTC_2824 7998404 51.95 µM 0.470138260582872 0.316471455507078 no 1057 0.319128120205744 1551 837851 SGTC_3074 9116018 49.47 µM 0.46930731767079 0.316775089245016 no 1058 0.319424992716432 1566 17027303 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.466360626647364 0.317852829858408 no 1059 0.320478694766542 1536 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2605 digitonin 300 nM 0.46503765922795 0.318337203033196 no 1060 0.320952244102467 1580 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1948 st076329 66.6 µM 0.464434982623555 0.318557961867366 no 1061 0.321168065730995 1456 24208413 SGTC_1320 1313-0481 95.3 µM 0.463259678941117 0.318988657747088 no 1062 0.321589121837668 1601 6813365 YLR208W SEC13 SGTC_1023 4482-3888 16 µM 0.462326609187863 0.319330759951709 no 1063 0.32192356021908 1638 3303168 SGTC_534 k292-0788 63.4 µM 0.462070681897596 0.319424620449676 no 1064 0.322015316968962 1633 4146317 SGTC_799 1310-0557 151 µM 0.458845564486777 0.320608411765593 no 1065 0.323172535884252 1562 5354492 SGTC_569 4130-2812 160 µM 0.454288161247619 0.32228433692272 no 1066 0.324810717945683 1563 743552 SGTC_1147 3809-1045 12.3 µM 0.452524769809803 0.322933773960774 no 1067 0.325445490555204 1512 325925 SGTC_557 1315-0110 16.2 µM 0.451801488455215 0.323200306632146 no 1068 0.32570599866622 1492 6833801 SGTC_114 0364-0001 490.298 µM 0.451356371337659 0.323364379575482 no 1069 0.32586636120643 1480 4003655 SGTC_1189 1431-2119 7.28 µM 0.451216480166685 0.323415951429921 no 1070 0.325916766515955 1560 3107275 SGTC_2386 9075165 157.42 µM 0.451145250171362 0.323442212167399 no 1071 0.325942433189275 1516 16452277 SGTC_3049 9092223 49.47 µM 0.450242631343097 0.3237750615539 no 1072 0.326267749922927 1563 8623917 SGTC_1299 1079-1439 3.74 µM 0.450159178599488 0.323805842681321 no 1073 0.326297834166519 1498 323161 SGTC_1624 st003710 6.25 µM 0.449662964888908 0.323988893509599 no 1074 0.326476739745404 1639 24207033 SGTC_917 harmaline 728.087 nM 0.449529329416079 0.324038198264327 no 1075 0.326524927689124 1605 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2204 7233102 200 µM 0.44860901642361 0.324377831168146 no 1076 0.326856864193578 1579 2172480 SGTC_1118 chelidonine 707.474 nM 0.44813990736656 0.324551007732761 no 1077 0.327026114192067 1683 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2887 9044784 58.44 µM 0.447596153356842 0.324751787748838 no 1078 0.327222339892041 1524 6465546 SGTC_1814 st052110 31.539 µM 0.44180531706005 0.326893191227318 no 1079 0.329315045322495 1655 674163 SGTC_3183 9108214 49.47 µM 0.441114209720219 0.3271491400056 no 1080 0.32956515842885 1543 4974831 SGTC_1519 esterone 74 µM 0.438636908893418 0.328067265638005 no 1081 0.330462324402501 1491 698 A steroid. SGTC_2775 cyproheptadine 69.59 µM 0.436692574966795 0.328788594284297 no 1082 0.331167157384309 1578 2913 A selective serotonin reuptake inhibitor. SGTC_2746 daunorubicin 9.88 µM 0.436102815958674 0.329007515326224 no 1083 0.331381067086459 1617 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1495 4469-0029 237 µM 0.435160554323887 0.329357408555059 no 1084 0.33172294610729 1552 793680 SGTC_804 1595-0054 20.9 µM 0.434373929833396 0.329649623017926 no 1085 0.332008462990412 1564 761523 Stimulates phospholipase C. SGTC_2334 9017922 200 µM 0.433986192608622 0.329793697534224 no 1086 0.332149233806956 1723 3163164 SGTC_1634 st006576 41 µM 0.432910639655365 0.330193481206236 no 1087 0.332539845067305 1714 3915356 SGTC_516 3992-2719 87.3 µM 0.432859075131624 0.330212652645836 no 1088 0.332558576457347 1478 5350887 YDR037W KRS1 SGTC_423 5-fluorouracil 457 µM 0.431363553003363 0.330768874283741 no 1089 0.333102023341023 1486 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_707 0865-0008 204 µM 0.430234397178376 0.331189083026226 no 1090 0.33351257145081 1652 723043 SGTC_2285 7945142 200 µM 0.430124132597385 0.331230128752234 no 1091 0.333552673086585 1586 2970608 SGTC_2155 5570423 76 µM 0.429633685765208 0.331412720972916 no 1092 0.333731064555376 1580 797402 SGTC_2081 5214970 32.255 µM 0.429194743977823 0.331576171973594 no 1093 0.333890753843471 1667 2063512 SGTC_3001 9076041 71.4286 µM 0.428661328938328 0.331774845636699 no 1094 0.334084853483143 1564 16004211 SGTC_2733 amorolfine 100 µM 0.42839995823536 0.331872212016593 no 1095 0.334179977542318 1663 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_171 k064-0041 9.68 µM 0.42838448299505 0.331877977242758 no 1096 0.334185609983028 1518 53325 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.426718151441689 0.332498993710806 no 1097 0.334792314040301 1505 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1846 st056244 14.8 µM 0.426436604341635 0.332603967516963 no 1098 0.334894866768334 1624 5393182 SGTC_2271 7849410 118.62 µM 0.423767074814023 0.33359994317097 no 1099 0.335867846222012 1707 972430 SGTC_682 0kpi-0099 17 µM 0.421199794275012 0.334558878310651 no 1100 0.336804597288882 1571 1714895 YML126C ERG13 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.419875670004852 0.335053890225025 no 1101 0.337288141140173 1842 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_197 4544-0043 41.561 µM 0.419146116603191 0.335326749718698 no 1102 0.337554674475677 1592 896523 SGTC_795 0685-0265 78 µM 0.418730360299612 0.33548228517283 no 1103 0.337706602383385 1588 302754 SGTC_3046 9092212 49.47 µM 0.418202102487953 0.33567994839089 no 1104 0.337899679351512 1618 25236637 SGTC_3328 9140624 29.0385 µM 0.417075323388475 0.336101717869418 no 1105 0.338311656903795 1722 4904392 SGTC_706 4262-0057 46.9 µM 0.416146809759821 0.336449428927218 no 1106 0.338651289388462 1555 883298 SGTC_540 1187-0821 17.3 µM 0.415999005792792 0.336504791675964 no 1107 0.338705365362393 1569 847520 SGTC_491 tetrandrine 80.3 µM 0.414426677420412 0.337093955971418 no 1108 0.339280827461743 1666 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_17 0960-0276 49.807 µM 0.413848540237711 0.337310689310684 no 1109 0.339492516343216 1617 6821114 SGTC_3229 9132204 49.47 µM 0.413525645111318 0.337431760451293 no 1110 0.339610768650877 1653 17682924 SGTC_1810 st050138 53 µM 0.4132564346735 0.337532715117705 no 1111 0.339709372348174 1692 3444541 SGTC_2846 9008642 19.48 µM 0.411522193242618 0.338183340544625 no 1112 0.340344835604735 1589 2992898 SGTC_1013 4112-3890 241 µM 0.410076638567194 0.338726030639175 no 1113 0.340874864592891 1580 705171 SGTC_90 0870-0863 4.608 µM 0.409501991878324 0.338941857597005 no 1114 0.341085652660905 1587 1738164 SGTC_1102 cgs 12066b 26.1 µM 0.408114759127995 0.339463095049089 no 1115 0.341594712448611 1624 6438352 A 5-HT1B full agonist. SGTC_2759 disulfiram 3.38 µM 0.406956537917635 0.339898519353861 no 1116 0.342019954881071 1562 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1381 2324-0066 62.1 µM 0.406380191827819 0.34011527186662 no 1117 0.342231635834906 1637 10885928 SGTC_2891 9063876 19.48 µM 0.406129835537587 0.340209442449036 no 1118 0.342323602388289 1692 6472478 SGTC_822 1487-0950 154 µM 0.405765052291604 0.340346672143876 no 1119 0.3424576195855 1686 1958375 SGTC_1716 st033144 30.6155 µM 0.404198600672467 0.340936203838106 no 1120 0.343033341332966 1739 674617 SGTC_3307 9126885 69.2785 µM 0.402582273270464 0.341544913608184 no 1121 0.343627776272077 1556 24824909 SGTC_478 N-arachidonylglycine 10 µM 0.401413103891111 0.341985480554506 no 1122 0.344058001643823 1645 5283389 SGTC_2246 7293507 91.5585 µM 0.399397543297436 0.34274549013145 no 1123 0.344800151925809 1784 887656 SGTC_1188 1403-0014 4.57 µM 0.397895756879661 0.343312184620217 no 1124 0.345353513946303 1624 9614867 SGTC_1079 idarubicin 2.36 µM 0.397206897521682 0.343572241583289 no 1125 0.345607448112849 1652 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1471 k673-0312 37 µM 0.397053458088936 0.343630177855207 no 1126 0.345664019944715 1645 24099884 SGTC_84 0443-0269 128.823 µM 0.395556020784276 0.344195778859152 no 1127 0.346216293297062 1625 6150058 SGTC_1438 4092-1045 4 µM 0.394938716027358 0.344429044247416 no 1128 0.346444058217799 1604 1351342 SGTC_3164 9100705 49.47 µM 0.392636266345098 0.345299608898297 no 1129 0.347294074836257 1717 17174235 SGTC_1609 st001574 46.4 µM 0.391945091931584 0.345561104545142 no 1130 0.347549392283176 1602 3960012 SGTC_2047 4141938 200 µM 0.391724812546203 0.345644459498543 no 1131 0.347630777270444 1648 3807862 SGTC_1146 3579-1023 7 µM 0.391486889274844 0.345734499404463 no 1132 0.347718688902258 1751 X1146 SGTC_956 1185-0240 191 µM 0.390320666995037 0.34617597179366 no 1133 0.348149721413825 1654 1416193 SGTC_2540 epiandrosterone 100 µM 0.389774418555999 0.346382825598116 no 1134 0.348351680837081 1650 441302 A steroid. SGTC_151 3013-0144 2.285 µM 0.388465251941222 0.346878768305865 no 1135 0.348835881941264 1725 906558 YHR107C CDC12 SGTC_1369 1866-0067 208 µM 0.388373412673517 0.346913569013626 no 1136 0.348869858357254 1745 3531355 SGTC_543 3844-1095 191 µM 0.387163472242427 0.347372172934839 no 1137 0.34931759519289 1732 4230703 SGTC_940 3232-1287 54.8 µM 0.386807927892159 0.347506977492373 no 1138 0.349449203809482 1691 1585493 YIL048W NEO1 SGTC_1225 1216-0074 20.6 µM 0.384034434481903 0.348559207771307 no 1139 0.350476462855696 1626 4241466 SGTC_178 4092-0806 87.505 µM 0.383378849268008 0.348808099692155 no 1140 0.350719441693199 1623 2169044 SGTC_144 4161-2749 112.381 µM 0.382771467867941 0.349038749188576 no 1141 0.350944609311494 1630 797501 YMR168C CEP3 SGTC_2898 9056270 58.44 µM 0.382704250847902 0.349064277884362 no 1142 0.350969531133912 1663 19154699 SGTC_248 streptozotocin 5.23457 mM 0.381813062435996 0.349402811416628 no 1143 0.351300014544963 1743 5300 DNA alkylating agent. SGTC_3043 9092303 49.47 µM 0.380691741167644 0.349828935169201 no 1144 0.351715998919335 1570 25236084 SGTC_1274 0865-0114 173 µM 0.379974069857892 0.350101763485249 no 1145 0.351982331696087 1678 870624 SGTC_285 1486-1325 46 µM 0.379848912505337 0.350149350952592 no 1146 0.352028785895195 1716 22310230 SGTC_2412 st077135 33.4 µM 0.379792495601342 0.350170802619825 no 1147 0.352049726674333 1735 13258915 SGTC_2652 actinonin 100 µM 0.373401768611434 0.352603858462192 no 1148 0.354424721688819 1678 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_177 1327-0068 8.361 µM 0.371552018628496 0.353309220986086 no 1149 0.355113209483394 1644 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1512 0259-0544 12.2 µM 0.371463710468393 0.353342908039316 no 1150 0.355146090153046 1727 18476 SGTC_2616 abietic acid 100 µM 0.371193711575721 0.353445912069198 no 1151 0.355246628258676 1810 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.370818934127473 0.353588906695186 no 1152 0.35538619891841 1747 688761 SGTC_3295 9122362 53.5725 µM 0.369643033842975 0.354037700133056 no 1153 0.355824241121182 1660 4730473 SGTC_2877 9040724 71.43 µM 0.36927159812295 0.354179504267248 no 1154 0.355962646641442 1800 6463895 SGTC_82 0054-0107 293.755 µM 0.368864700899843 0.354334869857466 no 1155 0.356114287725849 1790 3104697 SGTC_2813 7971799 71.43 µM 0.368080999213932 0.354634179018668 no 1156 0.356406419145799 1702 2234054 SGTC_1395 3486-0190 4.35 µM 0.367830329811172 0.354729932935698 no 1157 0.356499876079635 1815 6748079 SGTC_835 0312-0010 67.2 µM 0.367633470428167 0.354805138245827 no 1158 0.356573277095249 1662 1626196 SGTC_143 4032-1194 15.74 µM 0.3654832020975 0.355626963545793 no 1159 0.357375371819862 1670 1806963 SGTC_1850 st056238 17 µM 0.364284166899075 0.356085522672595 no 1160 0.35782291090471 1646 5393177 SGTC_770 0389-1121 67.2 µM 0.363344261121891 0.356445125958136 no 1161 0.358173866840632 1802 6753108 SGTC_1398 3558-0053 112 µM 0.362293689691989 0.356847220472009 no 1162 0.358566286621538 1676 4532369 SGTC_2518 prenyletin 46.28 µM 0.361756649137816 0.357052828244449 no 1163 0.358766945020828 1773 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1933 st074711 15.9 µM 0.358452769589776 0.358318641035196 no 1164 0.36000225356065 1646 17250958 SGTC_708 3448-5400 146 µM 0.355806476933244 0.359333638061767 no 1165 0.360992749107486 1717 3462195 SGTC_2642 cholecalciferol 100 µM 0.354508162629794 0.359831975873899 no 1166 0.361479043923302 1757 9821465 A vitamin D precursor, similar to steriods. SGTC_2867 9039098 71.43 µM 0.352739276799407 0.360511318784667 no 1167 0.362141955516804 1669 6463460 SGTC_3099 9120367 49.47 µM 0.352535942617594 0.360589437812336 no 1168 0.362218184036336 1697 24824940 SGTC_867 0518-0118 155 µM 0.351476525338857 0.360996549760992 no 1169 0.362615440283115 1718 6848158 SGTC_93 0109-0045 59.227 µM 0.350921105082258 0.361210049145015 no 1170 0.362823768790849 1762 88733 SGTC_1891 st059073 26.2 µM 0.350022808715052 0.361555439027112 no 1171 0.363160790108395 1836 688754 SGTC_2274 7947094 46.08 µM 0.349773486888207 0.361651321879682 no 1172 0.363254349051652 1646 2971028 SGTC_1782 st039423 80.636 µM 0.347564800708207 0.362501105317693 no 1173 0.364083522476888 1650 2068169 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.346434665859522 0.362936182751153 no 1174 0.364508038288318 1813 688798 SGTC_1386 3228-0095 33.8 µM 0.345977295304219 0.36311231084216 no 1175 0.364679888987884 1788 870181 SGTC_839 0122-0028 230 µM 0.345889691308686 0.363146049428792 no 1176 0.364712808089438 1728 759448 SGTC_1669 st015249 58.4 µM 0.345739463793813 0.363203908440156 no 1177 0.36476926165861 1842 722793 SGTC_2119 5528445 120.635 µM 0.345284885538873 0.363379004887952 no 1178 0.364940104180005 1794 791935 SGTC_2286 7945697 125 µM 0.345132633225793 0.363437656486416 no 1179 0.364997330619543 1626 1245733 SGTC_3134 9127454 49.47 µM 0.344977645293967 0.363497365205458 no 1180 0.365055588373344 1735 24262820 SGTC_1006 4099-6547 255 µM 0.3448293935644 0.363554481922315 no 1181 0.365111316999612 1749 3146833 SGTC_87 0100-0052 35.5 µM 0.344811577351634 0.363561346151501 no 1182 0.365118014402051 1764 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_193 1273-0060 1.558 µM 0.343780929616626 0.363958508529919 no 1183 0.365505521522977 1784 2847393 YHR072W ERG7 SGTC_272 doxorubicin 8.13 µM 0.343548392517836 0.364048137440766 no 1184 0.365592970765724 1711 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_74 000s-0487 160.283 µM 0.34286392622168 0.364312000723039 no 1185 0.365850415640988 1713 677548 SGTC_2685 mycophenolic acid 18.85 µM 0.34230584178759 0.364527191125668 no 1186 0.366060369863828 1779 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2602 kawain 100 µM 0.339947349379704 0.365437067198844 no 1187 0.366948089056544 1732 5369129 SGTC_3224 9130643 49.47 µM 0.339508027922664 0.365606635651989 no 1188 0.36711352522014 1779 17644395 SGTC_376 3970-0862 59.1 µM 0.339474318396492 0.365619647875692 no 1189 0.367126220303882 1813 3135186 SGTC_680 0417-1641 114 µM 0.339161464496928 0.365740420073273 no 1190 0.367244048718696 1698 2835990 SGTC_169 k015-0017 16.025 µM 0.337561709171656 0.366358187574437 no 1191 0.367846750831155 1793 1840002 SGTC_1816 st051957 91.6 µM 0.337556543643644 0.366360182876093 no 1192 0.367848697453444 1731 674121 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.336568001905748 0.366742095853177 no 1193 0.368221290504466 1723 3256 An antibiotic and ribosome inhibitor. SGTC_132 0417-1715 25.805 µM 0.335991598397972 0.366964844373916 no 1194 0.368438601036172 1867 6769098 SGTC_407 eburnamonine 100 µM 0.334759558743408 0.367441110630594 no 1195 0.36890323473562 1691 3195 SGTC_415 dibenzyl ketone 100 µM 0.334698890726278 0.367464568178177 no 1196 0.368926119154901 1837 7593 SGTC_3355 9151058 44.0485 µM 0.332266440438329 0.368405492019086 no 1197 0.369844039191568 1750 17015728 SGTC_2792 7535235 81.82 µM 0.331444283290564 0.368723698857152 no 1198 0.370154460056407 1654 1281891 SGTC_2287 7945887 168.79 µM 0.330527011524736 0.36907882500313 no 1199 0.370500893070555 1851 1245853 SGTC_2196 6573537 42.6665 µM 0.33015452155301 0.369223068205195 no 1200 0.370641604200705 1829 2903087 SGTC_2117 5521686 200 µM 0.329751985217395 0.369378967278993 no 1201 0.370793685045587 1688 803312 SGTC_1641 st009299 47.1 µM 0.329448326562802 0.369496586041464 no 1202 0.370908422619622 1800 4046054 SGTC_2545 solidagenone 89.61 µM 0.329377290517352 0.369524102817541 no 1203 0.370935265281903 1727 6708572 An anti ulcer agent SGTC_2696 st077691 74.316 µM 0.32780447577104 0.370133524928786 no 1204 0.371529751489462 1749 757133 SGTC_1468 k284-1086 134 µM 0.327668984303303 0.370186039397976 no 1205 0.371580978372501 1734 15996457 SGTC_2437 5741531 144.16 µM 0.325239645731369 0.371128024558086 no 1206 0.372499852681664 1859 2262990 SGTC_280 3448-3607 3.04 µM 0.322747605515096 0.372095125396581 no 1207 0.373443197916575 1862 626179 SGTC_928 2764-0428 58.7 µM 0.321660493852167 0.372517260570866 no 1208 0.373854954890206 1798 662578 SGTC_3298 9116858 71.43 µM 0.321197051969359 0.372697265798856 no 1209 0.374030533036215 1847 2506942 SGTC_324 1315-0088 19.6 µM 0.32001788724713 0.373155389866244 no 1210 0.374477385483393 1783 6787421 SGTC_1704 st028805 70.8 µM 0.319813616393575 0.37323477055865 no 1211 0.374554812459456 1734 2876101 SGTC_2084 5306078 60.6385 µM 0.319366546556278 0.373408522941862 no 1212 0.374724287788896 1817 679340 SGTC_1980 st071811 45.7 µM 0.319349090009628 0.373415307899999 no 1213 0.374730905711424 1823 4974850 SGTC_320 4092-0846 5.34 µM 0.318961234952375 0.373566068358078 no 1214 0.374877954313478 1818 1359356 SGTC_1668 st014914 51.6 µM 0.317155466869074 0.374268230429029 no 1215 0.375562819560031 1764 2839556 SGTC_2396 5342950 42.78 µM 0.316976525010166 0.374337833656877 no 1216 0.375630707403668 1736 1886677 SGTC_772 k072-0172 35.3 µM 0.316552866121493 0.374502641083114 no 1217 0.375791452546579 1653 5861980 SGTC_1680 diphenhydramine 100 µM 0.313601705113573 0.375651306065774 no 1218 0.376911782168067 1749 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2055 5235184 200 µM 0.30931675828319 0.3773210747642 no 1219 0.378540292179136 1772 2836034 SGTC_288 1315-0019 35.1 µM 0.308677819911291 0.377570255321914 no 1220 0.378783308788962 1787 6811474 SGTC_1375 2910-0797 186 µM 0.308672138877878 0.377572471105613 no 1221 0.37878546975314 1776 742508 SGTC_2934 9036370 36.88 µM 0.306587464262878 0.37838583196235 no 1222 0.379578698246112 1881 6462800 SGTC_2017 5132927 60.65 µM 0.306174812710995 0.378546896961125 no 1223 0.379735774329599 1698 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2521 angolensin 13.4 µM 0.305086540885423 0.378971769310472 no 1224 0.380150120838861 1806 821428 A flavenoid. SGTC_517 1365-0151 113 µM 0.304897798872449 0.379045471003475 no 1225 0.380221996121068 1792 768657 SGTC_3289 9119912 71.43 µM 0.303884836671048 0.379441096740932 no 1226 0.380607815211076 1793 17014829 SGTC_1184 1269-1718 139 µM 0.302925066184627 0.379816064263703 no 1227 0.380973484129269 1883 5403821 SGTC_120 rhodamine 6G 52.259 µM 0.302875785448342 0.379835320540865 no 1228 0.380992262775635 1732 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_660 4031-1742 102 µM 0.300461091704163 0.380779217874243 no 1229 0.381912735221715 1768 6738706 SGTC_1319 1306-0155 43.7 µM 0.29907910781439 0.381319751527557 no 1230 0.382439843339765 1807 3122360 SGTC_2146 5545642 200 µM 0.298850978543212 0.381409001746383 no 1231 0.382526876035703 1825 825326 SGTC_1263 0774-1208 64.8 µM 0.298133286487163 0.381689823015249 no 1232 0.382800718572073 1920 906585 SGTC_591 4299-0174 154 µM 0.297778563058528 0.381828643550785 no 1233 0.382936088468764 1838 5509088 SGTC_988 1497-1057 103 µM 0.297775462363222 0.381829857070742 no 1234 0.382937271822162 1956 3533044 SGTC_1805 st050013 60.3 µM 0.293686924752877 0.38343099512422 no 1235 0.384498573239591 1866 4037144 SGTC_1746 st038117 42 µM 0.293246991788124 0.383603399290022 no 1236 0.384666683889683 1775 2898218 SGTC_167 3672-0051 66.205 µM 0.292905328576046 0.383737308683681 no 1237 0.384797257892362 1744 3237971 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.292843555489071 0.383761521132949 no 1238 0.38482086721193 1882 165506 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.291414551107965 0.384321757179212 no 1239 0.385367143538782 1764 2724 A muscle relaxant with antifungal properties. SGTC_2762 leflunomide 42.06 µM 0.291169586141224 0.384417819120447 no 1240 0.385460811025659 1799 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_446 go6976 132 µM 0.289748100890149 0.384975388286377 no 1241 0.386004477399449 1921 3501 A protein kinase C inhibitor. SGTC_1985 st071382 65.5 µM 0.288976067940155 0.385278313415828 no 1242 0.386299845821828 1794 6123237 SGTC_1553 gossypol 38.6 µM 0.288553182678501 0.385444271998666 no 1243 0.386461663433767 1825 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1824 st053723 68.6 µM 0.287412549998979 0.38589201043048 no 1244 0.386898226445182 1744 675225 SGTC_484 loperamide 105 µM 0.286345092432087 0.386311162808736 no 1245 0.387306912262701 1816 3955 An opioid-receptor agonist. SGTC_1241 0364-0022 50.8 µM 0.285659715243808 0.386580355888683 no 1246 0.38756938102859 1834 4563895 SGTC_541 4513-1321 94 µM 0.285152350664183 0.38677966678001 no 1247 0.387763712048315 1754 747515 SGTC_1962 st076595 64.5 µM 0.284163203591483 0.387168324831326 no 1248 0.388142656425911 1795 279619 SGTC_2142 5622915 118.518 µM 0.283211594029435 0.387542340344781 no 1249 0.388507320647289 1797 5322196 SGTC_3319 9138450 16.7555 µM 0.282227808412651 0.387929111906404 no 1250 0.388884418314892 1806 2029690 SGTC_850 0388-0143 75.9 µM 0.281994225445153 0.388020960509604 no 1251 0.388973969063394 1799 67273 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.280394121025174 0.38865031565245 no 1252 0.389587573484736 1780 6708760 SGTC_875 0709-0210 25.7 µM 0.279843922709707 0.388866788004761 no 1253 0.389798625982855 1964 6251364 SGTC_2028 5153890 36.43 µM 0.278464122839397 0.389409813950383 no 1254 0.390328051058883 1800 2830968 YPR165W RHO1 SGTC_1963 st076565 50.3 µM 0.277598721660655 0.389750506464606 no 1255 0.390660206777851 1778 4914280 SGTC_138 0850-0259 40.9225 µM 0.277576515368294 0.389759249789235 no 1256 0.390668730982412 1869 6813004 SGTC_2366 9070441 60.58 µM 0.276522940745531 0.390174139715713 no 1257 0.391073221062418 1764 6837235 SGTC_1917 st066507 28.5 µM 0.275243713154418 0.390678058278789 no 1258 0.391564502584927 1774 3156428 SGTC_303 1348-1668 34.2 µM 0.275034863367963 0.390760346703005 no 1259 0.391644726841454 1854 5380509 SGTC_1708 st033234 31.827 µM 0.272114655084212 0.391911442101442 no 1260 0.392766930727731 1921 674664 SGTC_2910 7948405 25.97 µM 0.270874294890082 0.392400657621461 no 1261 0.393243857936936 1953 2971328 SGTC_2603 homopterocarpin 100 µM 0.269313281392325 0.393016584971852 no 1262 0.393844306278923 1812 101795 A weak amylase inhibitor. SGTC_1730 st033808 45.1 µM 0.268540356387802 0.393321656401102 no 1263 0.39414170765228 1813 1045166 SGTC_3321 9137793 26.8275 µM 0.267040375062247 0.393913881793376 no 1264 0.39471903733498 1879 4904192 SGTC_2185 6113692 200 µM 0.266891495147849 0.393972676246256 no 1265 0.394776352548678 1852 874150 SGTC_2763 lisinopril 49.32 µM 0.266736254119186 0.394033985352685 no 1266 0.394836119065021 1958 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2360 9040895 200 µM 0.266701849018425 0.394047573263034 no 1267 0.394849365080278 1793 4914414 SGTC_2558 carylophyllene oxide 100 µM 0.266180990667976 0.394253296198753 no 1268 0.395049911164301 1860 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2079 5212404 121 µM 0.266084611465452 0.394291366238712 no 1269 0.395087023097573 1963 758462 SGTC_797 k781-0471 270 µM 0.264633935243 0.394864508983503 no 1270 0.395645737648465 1886 23738129 SGTC_2757 clomiphene 4.22 µM 0.264431737667963 0.39494441263724 no 1271 0.395723629236901 1968 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1088 bifonazole 369 nM 0.264380937155699 0.394964488481367 no 1272 0.395743199525915 1886 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2227 7312221 64.1025 µM 0.264327780225024 0.394985495856576 no 1273 0.395763677878319 1915 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1765 st044815 90.4 µM 0.262764162327794 0.395603566792485 no 1274 0.396366179714241 1769 645695 SGTC_3276 9139060 49.47 µM 0.262727022306788 0.395618250795669 no 1275 0.396380493726921 1865 4870619 SGTC_1439 4092-1168 46 µM 0.262711410549106 0.395624423240814 no 1276 0.396386510644519 1866 2886240 SGTC_2354 9060492 162 µM 0.26141329682124 0.396137751950409 no 1277 0.396886902035411 1930 6471895 SGTC_2034 5197015 53.07 µM 0.26100951015323 0.396297462938286 no 1278 0.397042586679786 1953 780676 SGTC_1269 0831-0796 3.05 µM 0.260646142097813 0.39644120190732 no 1279 0.39718270148609 1928 927758 SGTC_2645 abamectin 100 µM 0.260263524274795 0.396592570799194 no 1280 0.397330253351063 1923 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.258785344397375 0.397177505384214 no 1281 0.397900433130283 1834 115019 SGTC_2869 9037858 32.47 µM 0.257869904901029 0.39753987253263 no 1282 0.398253655968397 1910 27187042 SGTC_2569 tetrandrine 100 µM 0.257730633449978 0.397595009437944 no 1283 0.398307401250624 1765 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_906 1165-0455 526 µM 0.257642632703682 0.397629849569868 no 1284 0.398341362004535 1809 3252859 SGTC_2174 5790901 200 µM 0.25648851793794 0.398086847433217 no 1285 0.398786822671094 1840 786020 SGTC_254 nsc-64875 3.808 µM 0.256180637316581 0.398208783388651 no 1286 0.398905679526121 1972 56993 SGTC_970 1315-0089 19.5 µM 0.256061323395285 0.398256040276756 no 1287 0.398951743008727 1833 6811083 YLR033W RSC58 SGTC_3245 9134821 49.47 µM 0.255732131434178 0.39838643168957 no 1288 0.399078841326678 1789 17014901 SGTC_1855 st056195 39.6 µM 0.253382928262634 0.399317268764722 no 1289 0.39998615929255 1984 4028379 SGTC_1926 methyl fluorone black 53.6 µM 0.252534906575799 0.399653425799542 no 1290 0.400313818327909 1879 72721 Reacts with homocysteine. SGTC_277 nystatin 15.5 µM 0.251702367660293 0.399983517814999 no 1291 0.40063556339095 1804 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1446 4239-0190 62 µM 0.251350961794813 0.400122867627338 no 1292 0.40077138882632 1832 1340085 SGTC_1633 st005664 67.9 µM 0.250541308523355 0.400443983589402 no 1293 0.401084381741764 1830 2063822 SGTC_2980 9014342 25.29 µM 0.250339170235255 0.400524164008197 no 1294 0.401162533563408 1867 2996599 SGTC_857 0438-0306 1.35 µM 0.247439738951496 0.401674715665123 no 1295 0.402283961443906 1888 4686136 SGTC_2878 9043973 25.97 µM 0.246582637015258 0.402014994423458 no 1296 0.402615621670673 1964 6465167 SGTC_751 0833-0568 350 µM 0.24640868429581 0.402084064614863 no 1297 0.402682942180685 1885 6954252 SGTC_1775 st081588 35.1725 µM 0.246348935232162 0.402107789463909 no 1298 0.402706066011603 1866 1426443 YGL099W LSG1 SGTC_1557 sumaresinolic acid 42.3 µM 0.246137702371908 0.402191667606064 no 1299 0.402787819191519 1832 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2411 st077133 39.94 µM 0.245861999205522 0.402301152941687 no 1300 0.402894530624511 2014 1403142 YNL221C POP1 SGTC_904 1141-0088 396 µM 0.243467048264357 0.40325254090547 no 1301 0.403821804443025 1797 1378119 SGTC_3102 9121669 49.47 µM 0.242809506241049 0.403513848228501 no 1302 0.404076485502382 1885 41905072 SGTC_1417 3966-0327 90.4 µM 0.241164108995038 0.404167917934876 no 1303 0.404713963443361 1896 651118 SGTC_1567 st069303 68.4 µM 0.241055155537013 0.40421123802357 no 1304 0.404756184342528 1871 5581319 SGTC_2453 5731132 22.18 µM 0.240680081753056 0.404360377005797 no 1305 0.404901538847467 1989 1362040 SGTC_513 4245-1575 41.7 µM 0.240487304483405 0.404437035614914 no 1306 0.404976252040332 1956 719745 SGTC_2417 cerulenin 830 nM 0.238104379429745 0.405384916844923 no 1307 0.405900069058686 1908 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2502 avocadyne acetate 18.59 µM 0.238010926684538 0.405422101878578 no 1308 0.405936309717241 1920 3952079 SGTC_130 0136-0219 337.655 µM 0.237435667216251 0.405651017556512 no 1309 0.406159411135626 2014 234244 SGTC_544 k015-0020 52.4 µM 0.237359532454888 0.405681316636292 no 1310 0.4061889405718 1878 3008304 SGTC_290 2043-6722 48.1 µM 0.23587527076874 0.406272115651447 no 1311 0.406764728970208 1929 773758 YLR208W SEC13 SGTC_1447 4239-0816 81.9 µM 0.234493463827636 0.40682232524805 no 1312 0.407300953433175 1811 1341554 SGTC_1625 st003711 30.1 µM 0.233785488078863 0.407104299252045 no 1313 0.407575758126681 1958 24207034 YER133W GLC7 SGTC_568 1193-0097 7.48 µM 0.233645022677777 0.407160249823627 no 1314 0.407630285959135 1966 3646150 SGTC_1522 st012842 45.6 µM 0.233610444986686 0.407174023196913 no 1315 0.407643709087489 1782 3491067 YOR116C RPO31 SGTC_3329 9141233 27.5565 µM 0.233437821850161 0.407242786095134 no 1316 0.407710723353477 1977 4909101 YNL103W MET4 SGTC_1617 st002906 78 µM 0.233203727343298 0.4073360401362 no 1317 0.407801605818816 1873 5150859 SGTC_2242 6630449 61.2675 µM 0.232737876422693 0.407521632434849 no 1318 0.407982477788481 1919 691249 YDR170C SEC7 SGTC_1420 4'-methoxyflavone 42 µM 0.229905261342665 0.408650575235148 no 1319 0.40908269393548 2012 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.228867307892188 0.409064443440728 no 1320 0.409486025356163 1940 676296 Flavone; oxidizing agent. SGTC_817 1391-0715 46 µM 0.227728365975527 0.409518695929159 no 1321 0.409928709459874 1856 1353946 SGTC_1458 k015-0034 6.33 µM 0.225307717812765 0.410484543451158 no 1322 0.41086994803651 1817 3598957 SGTC_1666 st014829 29 µM 0.225179778822559 0.410535606742044 no 1323 0.410919709835661 1886 3858230 SGTC_2161 5662504 8.5105 µM 0.224742732889844 0.410710052908886 no 1324 0.411089709417059 1886 2859334 SGTC_2207 7258803 200 µM 0.224316117431089 0.410880352806059 no 1325 0.411255667919318 1982 3666799 SGTC_1234 0326-0494 15.5 µM 0.223828708136274 0.411074941450651 no 1326 0.411445295385947 1993 1547813 SGTC_3035 9091303 49.47 µM 0.222571114102741 0.41157711227258 no 1327 0.411934660067393 1934 25237002 SGTC_2827 7993847 71.43 µM 0.22091280983161 0.412239512359359 no 1328 0.412580161509788 1913 2985692 SGTC_509 pifithrin 175 µM 0.219763753942534 0.412698642911628 no 1329 0.413027574844441 1983 4817 A p53 inhibitor. SGTC_2734 clemastine 41.6 µM 0.219483429279782 0.412810670947726 no 1330 0.41313674335359 1995 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1964 st076914 61 µM 0.217417680102341 0.413636438644231 no 1331 0.413941426998464 2005 24208661 SGTC_2338 7999974 200 µM 0.217068997610678 0.413775859637414 no 1332 0.414077287124294 2054 315925 SGTC_1961 st076550 68.7 µM 0.216921889001649 0.413834684402245 no 1333 0.414134609388632 1929 1579337 SGTC_426 0988-0037 14.6 µM 0.214346658596042 0.41486476163228 no 1334 0.415138367574287 2095 5383008 SGTC_600 1495-0418 41.6 µM 0.21423413548544 0.414909783628364 no 1335 0.415182238854963 1930 5377768 SGTC_1868 st057644 42.7 µM 0.213933636705003 0.415030022670988 no 1336 0.415299404558641 1962 688665 SGTC_3097 9117246 49.47 µM 0.213002512853331 0.415402645195059 no 1337 0.415662501342914 1976 16423892 SGTC_323 4013-0906 34.3 µM 0.212389193289028 0.415648128553508 no 1338 0.415901707987737 2047 2910086 SGTC_208 k072-0098 12.366 µM 0.211538877051359 0.415988525126883 no 1339 0.416233399509784 2044 5948901 SGTC_385 1494-0393 12.4 µM 0.211360166614589 0.416060074088451 no 1340 0.416303118507152 1962 3090647 SGTC_3239 9133757 49.47 µM 0.211105267286298 0.416162131040431 no 1341 0.416402565076658 1983 17036923 SGTC_2282 7944268 200 µM 0.210750868611208 0.416304035073588 no 1342 0.416540839269308 1996 2970414 SGTC_2534 helenine 20.12 µM 0.210750440510312 0.416304206495175 no 1343 0.416541006305825 1907 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1787 fluconazole 80 µM 0.209374229334753 0.416855355667731 no 1344 0.417078054467167 1952 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_575 k072-0246 11.9 µM 0.209015213324841 0.416999162401628 no 1345 0.417218181197427 1934 6796779 SGTC_1127 asiatic acid 681.4 nM 0.20865590607784 0.41714309691249 no 1346 0.417358432128052 1830 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_673 1082-0474 110 µM 0.206166264743073 0.418140723756808 no 1347 0.418330519293949 1906 3098046 SGTC_2635 hydroquinidine 100 µM 0.204289122149013 0.418893264350704 no 1348 0.419063784998906 1937 442912 An experimental heart treatment. SGTC_1355 1499-0035 1.68 µM 0.204067890224734 0.418981975145882 no 1349 0.419150223104541 1905 1548538 SGTC_1530 rhein 70.4 µM 0.203708573014562 0.419126064916007 no 1350 0.419290621189034 2034 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3233 9132340 49.47 µM 0.202367082596253 0.419664111598373 no 1351 0.419814880139464 1912 17682950 SGTC_3018 9082602 49.47 µM 0.202207277158833 0.419728216599281 no 1352 0.419877342145806 1948 17332089 SGTC_1344 1488-0097 29.1 µM 0.200776051977093 0.420302438844918 no 1353 0.420436844685156 1969 747966 SGTC_1721 st082152 9.2685 µM 0.199956891035482 0.42063117105396 no 1354 0.420757148079182 1992 5296051 SGTC_2061 5245884 80.95 µM 0.199916212157919 0.420647497077347 no 1355 0.420773055458878 1943 573863 SGTC_1430 4049-0248 69.1 µM 0.199767770452141 0.420707073692903 no 1356 0.420831104337044 2048 22774488 SGTC_689 0833-0039 98 µM 0.19931677713722 0.420888089588679 no 1357 0.421007478103406 2040 5374726 SGTC_3156 9099931 49.47 µM 0.1990576816925 0.420992090702336 no 1358 0.42110881192126 1934 18111053 SGTC_2442 5158906 48.48 µM 0.198435786906518 0.421241742241413 no 1359 0.421352060102271 2039 1893835 SGTC_2311 7694451 200 µM 0.198434568931345 0.421242231212742 no 1360 0.421352536531062 1988 2163142 SGTC_33 0986-0033 35.816 µM 0.197755912860247 0.421514705028395 no 1361 0.421618020660476 2053 2848082 SGTC_1726 st035556 14.5795 µM 0.1974065538907 0.421654983921029 no 1362 0.421754700636201 2030 5919439 SGTC_1339 1486-1321 22.7 µM 0.196293920403462 0.422101808320422 no 1363 0.422190059821911 1933 3469382 SGTC_663 1486-0733 13.9 µM 0.196048280495152 0.422200468808741 no 1364 0.422286188394215 1947 722445 YPR165W RHO1 SGTC_421 streptovitacin 30 mM 0.195237952343246 0.422525969119674 no 1365 0.422603334515284 1908 91467 include heat shock SGTC_1205 4161-2785 76 µM 0.195016992249711 0.422614735659761 no 1366 0.422689822561694 1852 3498106 SGTC_816 0325-0417 81.3 µM 0.194497090236406 0.422823611958316 no 1367 0.422893336940777 1928 68101 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.193499538084482 0.423224450117285 no 1368 0.423283883887436 2051 91467 include heat shock SGTC_1516 st013856 110 µM 0.192726715985722 0.423535041513526 no 1369 0.423586499677443 1982 5281404 A mutagen and neurotoxin. SGTC_468 gf-109203x 121 µM 0.188888850051398 0.425078151224848 no 1370 0.425089966319345 2081 2396 A protein kinase C inhibitor. SGTC_1561 5-methoxyflavone 52.9 µM 0.187862416773361 0.425491049982355 no 1371 0.425492252597422 2081 94525 SGTC_1239 0337-0584 35.4 µM 0.187399343643175 0.425677355134044 no 1372 0.425673768592097 2085 914301 YML130C ERO1 SGTC_2116 5511452 16.8835 µM 0.186823860410942 0.425908908619629 no 1373 0.42589936918989 2008 870744 SGTC_1737 st035557 69.7 µM 0.186238417490207 0.426144495737793 no 1374 0.426128899068334 1934 5716916 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.182868131478815 0.427501237101269 no 1375 0.427450744301934 1949 4330530 SGTC_3075 9116269 49.47 µM 0.18282587612214 0.42751825288376 no 1376 0.42746732229479 2000 17015205 YNL244C SUI1 SGTC_1332 1480-0653 17.5 µM 0.182445954710297 0.427671249245603 no 1377 0.427616382150668 2112 5749438 SGTC_3291 9121177 71.43 µM 0.18233018002658 0.427717874486355 no 1378 0.427661807698901 1944 17015612 SGTC_308 4092-1169 104 µM 0.182266308319041 0.427743597586356 no 1379 0.427686868919204 2005 2268590 YDL196W YDL196W SGTC_2058 5236698 133 µM 0.18199057716615 0.427854646520715 no 1380 0.427795060373879 1973 766665 SGTC_454 lyso-paf C-16 6.67 µM 0.181589868149401 0.428016039664661 no 1381 0.427952300348269 1907 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1711 st032263 62.8 µM 0.180456263248717 0.428472685643608 no 1382 0.428397193769812 2022 3958979 SGTC_740 k014-0057 261 µM 0.179808705065753 0.428733582199078 no 1383 0.428651374675688 2076 4012779 SGTC_976 1348-1067 47.6 µM 0.179056207082042 0.429036797366003 no 1384 0.428946783947814 2025 5310671 YGL099W LSG1 SGTC_2026 5148700 152 µM 0.177016605912338 0.429858854199228 no 1385 0.429747672963775 1974 79838 SGTC_1414 3917-0015 5.4 µM 0.176614480803052 0.430020965863614 no 1386 0.42990560943154 2062 6618702 SGTC_2830 7992007 71.43 µM 0.175489563756174 0.430474524558146 no 1387 0.430347485225851 1901 1952075 SGTC_2714 st079313 56.9 µM 0.174894745047566 0.430714388422661 no 1388 0.430581169739808 1988 2939799 SGTC_1761 st044296 37 µM 0.174260107012733 0.430970337831409 no 1389 0.430830524749843 2021 1826700 SGTC_1230 0170-0365 3.77 µM 0.172210865143519 0.431796994155178 no 1390 0.431635878171422 2101 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3005 9076496 71.4286 µM 0.169845240715684 0.432751649281573 no 1391 0.43256592341852 2130 21368410 SGTC_2584 androsterone 48.74 µM 0.169277790241116 0.432980704292457 no 1392 0.432789072344052 2116 2754130 A steroid. SGTC_1199 1638-0010 4.46 µM 0.168489089572078 0.43329910574298 no 1393 0.43309926311618 1945 3111136 SGTC_2443 5493264 126.67 µM 0.166799998891855 0.43398114345853 no 1394 0.433763709779286 2073 5340055 SGTC_1958 st076513 41.9 µM 0.166788564717151 0.433985761134707 no 1395 0.433768208342017 2002 732122 YGL099W LSG1 SGTC_2781 5567276 71.43 µM 0.166239229701346 0.434207619948568 no 1396 0.433984344052602 2061 2853274 SGTC_1825 st052143 62.6 µM 0.165896437649528 0.434346073181997 no 1397 0.434119225496565 2096 674173 SGTC_3272 9137413 49.47 µM 0.165598992566722 0.434466217364105 no 1398 0.434236270080679 2143 17614870 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.165213221624344 0.434622047190225 no 1399 0.434388079460002 1955 2374 Ca(2+)-ATPase inhibitor. SGTC_2940 9060638 45.86 µM 0.161666575407721 0.436055166278526 no 1400 0.435784213596037 2001 4027022 SGTC_3349 9149703 23.001 µM 0.160535961231675 0.436512199222486 no 1401 0.436229447997465 2106 4910494 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.160311859106357 0.436602799056597 no 1402 0.436317708739734 2101 6710655 SGTC_2428 5615643 7.78 µM 0.160243552489335 0.436630414664513 no 1403 0.436344611358634 2068 2253075 SGTC_3057 9095946 49.47 µM 0.159049377328262 0.437113256221608 no 1404 0.436814985722385 2119 24540043 SGTC_1477 0139-0234 16 µM 0.158146221631793 0.437478491965213 no 1405 0.437170789631696 2125 620880 SGTC_3337 9144342 33.5465 µM 0.1580679373421 0.437510152609341 no 1406 0.437201632621284 2082 17682949 SGTC_1185 1319-0113 81.3 µM 0.157916482974801 0.437571406684084 no 1407 0.437261304750868 2054 4672763 SGTC_3216 9129716 49.47 µM 0.15747160700896 0.437751340585834 no 1408 0.437436591511973 2030 8056934 SGTC_3163 9099914 49.47 µM 0.15524965607615 0.43865021968166 no 1409 0.438312251461479 2145 16268368 SGTC_344 k064-0035 6.43 µM 0.154905225245642 0.43878958589838 no 1410 0.438448017112303 1947 5088750 SGTC_1244 0416-0015 52.5 µM 0.154816067702707 0.438825662737306 no 1411 0.438483161871425 2018 96201 SGTC_965 1291-5240 308 µM 0.154189659454233 0.439079147802457 no 1412 0.438730097625062 2101 2834598 SGTC_2492 derrusnin 100 µM 0.154050010537886 0.439135662145263 no 1413 0.438785151735999 2022 1715307 Part of coumarin class of compounds. SGTC_2925 9010536 32.5 µM 0.152703871581936 0.439680492865236 no 1414 0.43931590374784 2041 2994177 SGTC_307 1501-1223 22.3 µM 0.151523841994437 0.440158187186364 no 1415 0.439781252388122 2065 2830329 SGTC_2317 5986382 200 µM 0.15124759848159 0.440270027464705 no 1416 0.43989020199087 2093 877883 SGTC_2858 9025781 8.96 µM 0.151045602193588 0.44035181093994 no 1417 0.439969871595337 2139 4894980 YPL153C RAD53 SGTC_1546 5-methoxyflavanone 78.7 µM 0.150982729347813 0.440377267173841 no 1418 0.439994669847994 2153 147795 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.150663226420507 0.440506632728037 no 1419 0.440120691547854 2048 6708784 An antioxidant flavonoid SGTC_1753 st043925 64 µM 0.150409661580356 0.440609304714829 no 1420 0.440220709573249 2147 670181 SGTC_1941 st076221 61.8 µM 0.150404186401372 0.440611521736231 no 1421 0.440222869286183 2162 2828568 SGTC_880 0833-0487 87.2 µM 0.149756207514894 0.440873915886811 no 1422 0.440478480483666 2048 76075 SGTC_207 4185-0010 4.486 µM 0.147665456852262 0.44172072600121 no 1423 0.441303397076872 2137 3761753 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.147485721042025 0.441793536318825 no 1424 0.441374324719544 2144 279621 SGTC_741 4582-0002 126 µM 0.146226829492893 0.44230356366325 no 1425 0.441871163162731 2022 2912688 SGTC_2397 5161689 200 µM 0.14617501619688 0.44232455735805 no 1426 0.441891613940366 2094 2259942 SGTC_3063 1327-0034 4 µM 0.145784402092372 0.442482831466005 no 1427 0.442045794834526 2121 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_800 3448-7362 155 µM 0.143584948745025 0.443374205276283 no 1428 0.442914113324931 2170 15991913 SGTC_154 3389-1638 511.116 µM 0.143134591543994 0.443556757315421 no 1429 0.443091943050517 1898 5238686 SGTC_514 4466-0038 2.65 nM 0.142555822648816 0.443791378547106 no 1430 0.443320494724623 2046 5722064 SGTC_3348 9149464 3.537 µM 0.142529410796819 0.443802085849672 no 1431 0.443330925025508 2178 1951442 SGTC_345 1362-0200 395 µM 0.141248866641716 0.444321264498474 no 1432 0.443836671509397 1992 1419823 SGTC_2264 7948757 110.76 µM 0.140758723045574 0.444520011673155 no 1433 0.444030276281422 2023 2971411 SGTC_1148 3909-7663 27.7 µM 0.140467640989585 0.44463804845733 no 1434 0.444145258861191 2156 4084526 SGTC_457 grayanotoxin iii 135 µM 0.13953886424928 0.445014709806506 no 1435 0.444512173549284 2080 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1718 roemerine 11.9335 µM 0.139408785015667 0.445067466842858 no 1436 0.444563565355435 2160 235224 An aporphine alkaloid with mutagenic activity. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.138874690551642 0.445284093014759 no 1437 0.44477458557702 2157 688801 SGTC_931 2812-0076 566 µM 0.138571153756491 0.445407213379468 no 1438 0.444894519659321 2038 3450959 SGTC_186 3455-3465 67.277 µM 0.138146555350372 0.445579447494983 no 1439 0.445062296315686 2125 755278 SGTC_1947 st076332 61.6 µM 0.137809582959094 0.445716144302141 no 1440 0.445195455260752 2167 24208416 SGTC_488 nitrendipine 139 µM 0.137595800628616 0.445802870961422 no 1441 0.445279937286555 2170 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2717 st081029 62.2815 µM 0.136550141676334 0.446227108449553 no 1442 0.445693194199334 2170 5292846 SGTC_413 propylparaben 100 µM 0.136498956642671 0.446247876470335 no 1443 0.445713424654864 2029 7175 A pharmaceutical preservative. SGTC_2617 dihydrotanshinone i 20.83 µM 0.135908355072875 0.446487520171511 no 1444 0.44594686518643 2080 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1722 st034304 3.6505 µM 0.134149751428598 0.447201210193671 no 1445 0.446642079600108 2064 4036148 YLR033W RSC58 SGTC_50 0929-0078 56.389 µM 0.134062098435024 0.447236786697135 no 1446 0.446676735051183 2109 1377751 SGTC_3013 9080133 71.4286 µM 0.133808320004785 0.447339792408523 no 1447 0.446777073976487 2123 17050193 SGTC_3315 9136395 68.55 µM 0.133018585554833 0.447660359125424 no 1448 0.447089340984341 2188 16876844 SGTC_923 1900-2434 73.3 µM 0.13299810688024 0.447668672225293 no 1449 0.447097438845219 2161 5910570 SGTC_2098 5376439 882.5 nM 0.132848881006114 0.447729249573561 no 1450 0.447156447742274 2133 2844116 SGTC_1678 st019265 80.2 µM 0.132518285112334 0.447863457333447 no 1451 0.447287180570379 2186 5367020 SGTC_2272 7805186 180 µM 0.131861688453997 0.448130025111761 no 1452 0.447546846071496 2193 2956062 YPR165W RHO1 SGTC_2740 felodipine 17.08 µM 0.131595805102148 0.44823797618495 no 1453 0.447652001856599 2184 3333 L-type calcium channel blocker SGTC_1629 st005085 44.9 µM 0.130847467376007 0.44854182869884 no 1454 0.447947986113441 2043 24207091 SGTC_145 3737-0113 38.366 µM 0.13074973486198 0.448581513910123 no 1455 0.447986643645227 2186 6849351 SGTC_1886 st057356 49.9 µM 0.129963350741169 0.448900851308783 no 1456 0.448297711292451 1984 24207747 SGTC_1478 0453-0656 35.7 µM 0.12994257023332 0.448909290374281 no 1457 0.448305931808654 2156 5258496 SGTC_2391 6285546 200 µM 0.128732534733954 0.449400731422389 no 1458 0.448784645301313 2028 846083 SGTC_2477 5967686 25.23 µM 0.127761028858189 0.449795352812933 no 1459 0.449169045858477 2084 776118 SGTC_2086 5274770 176.623 µM 0.127594517977789 0.449862993791378 no 1460 0.44923493484568 2072 689278 SGTC_2452 5863136 48.41 µM 0.126149747793227 0.450449957337195 no 1461 0.449806694465649 2159 2184096 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.125738949833279 0.450616871151458 no 1462 0.449969284512437 2186 5355888 SGTC_1910 st062352 60.4 µM 0.125289860491254 0.450799353362072 no 1463 0.450147039543694 2121 2245730 SGTC_1046 2001-0062 216 µM 0.125164077115553 0.450850465834207 no 1464 0.450196827930302 2080 739778 SGTC_2996 9066192 71.4286 µM 0.124560905868099 0.451095577686664 no 1465 0.450435589939846 2054 6472854 SGTC_2128 5255449 168.493 µM 0.123614772706469 0.451480097162051 no 1466 0.450810147637196 2137 736008 SGTC_1689 st020265 53.493 µM 0.122668250041697 0.451864820493376 no 1467 0.451184903368433 2188 5758320 YPR016C TIF6 SGTC_2005 4024620 188 µM 0.121794351946309 0.452220065010066 no 1468 0.451530943571855 2165 236743 SGTC_1594 piperine 70.1 µM 0.121383648454007 0.452387031533251 no 1469 0.451693583876364 2080 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2868 9035608 32.47 µM 0.121277564889739 0.452430159889106 no 1470 0.451735594731225 2199 6462614 SGTC_864 0469-0573 172 µM 0.120549591874589 0.452726133001346 no 1471 0.45202389870232 2004 689425 SGTC_3137 9097352 49.47 µM 0.120049615104233 0.452929424554229 no 1472 0.452221922476932 2147 44120435 SGTC_1341 1486-1360 280 µM 0.119799646437684 0.45303106694258 no 1473 0.452320931014245 2069 3976547 SGTC_1583 clindamycin 39.6 µM 0.119790779844875 0.453034672337683 no 1474 0.452324442982433 2008 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1555 citronellol 128 µM 0.118391381495176 0.453603753676723 no 1475 0.452878777161736 2208 8842 A terpine precursor. SGTC_2526 patulin 37.61 µM 0.118170049811262 0.453693769493238 no 1476 0.452966460220622 2122 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_945 3381-0768 11.3 µM 0.117793917473419 0.453846748344181 no 1477 0.453115474573682 2195 1126236 YIL048W NEO1 SGTC_3135 9127742 49.47 µM 0.117111446729645 0.454124337241573 no 1478 0.453385869489424 2051 3643468 SGTC_2330 7979373 200 µM 0.116633324102755 0.454318822719782 no 1479 0.453575314560738 2047 1863007 SGTC_250 brefeldin a 552.239 µM 0.113653440395409 0.455531192170509 no 1480 0.454756261228733 2141 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1150 3909-7983 10.9 µM 0.112604449734195 0.45595807450279 no 1481 0.455172078556644 2066 23965914 SGTC_1539 benzyladenosine 56 µM 0.112385397654235 0.456047223258055 no 1482 0.455258916479062 2171 92208 A nucleotide analog. SGTC_1621 st003705 32.4 µM 0.112382653597781 0.456048340034911 no 1483 0.455260004307734 2205 24207032 SGTC_2966 9084041 48.03 µM 0.112361551774981 0.456056928072208 no 1484 0.455268369732795 2065 17741380 SGTC_734 2023-0417 80 µM 0.111765316659183 0.456299592802905 no 1485 0.455504744235797 2165 3935732 SGTC_2134 5324836 1.464 µM 0.111528654048293 0.45639591783416 no 1486 0.455598572345109 2141 699272 SGTC_1899 st063254 59.6 µM 0.111138249503851 0.456554823605325 no 1487 0.455753358943968 2101 3093813 SGTC_1725 st036284 20.55 µM 0.11107493999288 0.456580593035195 no 1488 0.455778460371018 2205 707914 SGTC_966 1300-0360 30.2 µM 0.11021377860602 0.45693113725727 no 1489 0.456119917548984 2118 70588 SGTC_2069 5228469 200 µM 0.110069541638501 0.456989853619468 no 1490 0.456177111802373 2113 2835210 SGTC_3340 9146634 11.102 µM 0.107963428713012 0.457847321879083 no 1491 0.457012351126285 2116 4907387 SGTC_2702 st077768 96.8 µM 0.107492295277246 0.458039162889199 no 1492 0.457199218693365 2102 6484119 SGTC_1295 1013-0063 9.78 µM 0.106423558316064 0.458474378485093 no 1493 0.457623151191823 2234 6826038 SGTC_2722 naftopidil 47.16 µM 0.106263309094796 0.458539640157094 no 1494 0.457686720910727 2195 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1490 4089-0339 670 nM 0.105265193136944 0.458946149070793 no 1495 0.458082690671691 2229 742542 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.105202974102343 0.458971490831165 no 1496 0.458107375414085 2091 688667 SGTC_2439 5492030 7.2 µM 0.103665971126679 0.459597563524052 no 1497 0.458717216110388 2234 5722370 SGTC_2307 7538926 6.34 µM 0.10330007364761 0.459746620623333 no 1498 0.458862408585339 2118 96582 SGTC_1123 mangostin 811.285 nM 0.103130658475418 0.459815637867864 no 1499 0.45892963640213 2079 5281650 An antioxidant. SGTC_2419 paclitaxel 166.5 µM 0.102464965988534 0.460086842884416 no 1500 0.459193809770485 2062 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3122 9126309 49.47 µM 0.102272215796656 0.460165373334544 no 1501 0.459270304114908 2248 17591206 SGTC_2248 tofa 1.1 µM 0.101405484367572 0.460518516963739 no 1502 0.459614291511381 2102 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1307 1187-1599 12.2 µM 0.100419865948198 0.460920138089719 no 1503 0.46000549936897 2137 1538471 SGTC_1623 st003709 20.3 µM 0.100067370423603 0.461063783141989 no 1504 0.460145419951801 2145 16192618 SGTC_3236 9132701 49.47 µM 0.0981293779147056 0.46185362252553 no 1505 0.460914779947662 2136 24282524 SGTC_927 2425-1185 123 µM 0.0979192983315926 0.46193925069664 no 1506 0.460998187887412 2223 730375 SGTC_665 3914-0008 307 µM 0.0957734374426862 0.462814001217947 no 1507 0.461850257105058 2183 1069549 SGTC_761 k216-0224 480 µM 0.0956857532534506 0.462849749136075 no 1508 0.461885078116774 2264 1340404 SGTC_36 0335-0881 14.2 µM 0.0951023433499702 0.463087606819172 no 1509 0.462116768395268 2185 23828853 SGTC_2036 5160441 105 µM 0.0949689009853946 0.463142013464017 no 1510 0.462169764331721 2156 134534 YIL048W NEO1 SGTC_1690 st023502 41.2 µM 0.0943633590324728 0.463388911516725 no 1511 0.462410260572983 2249 24207482 SGTC_3133 9127736 49.47 µM 0.0940119795330382 0.463532186202856 no 1512 0.462549820296825 2266 27243420 SGTC_3206 9114350 49.47 µM 0.0939619681957759 0.4635525786672 no 1513 0.462569684006173 2247 17087243 SGTC_194 1486-1323 56.904 µM 0.0939189792223265 0.463570107791279 no 1514 0.462586758618684 2113 5178754 SGTC_2156 5649887 115 µM 0.0926411487484363 0.464091186318058 no 1515 0.463094326161211 2213 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_939 1165-0479 45.3 µM 0.0924448458710191 0.464171240926055 no 1516 0.463172305049061 2259 1377347 SGTC_1991 st073000 8.92 µM 0.0901874849018542 0.465091922552292 no 1517 0.46406911469927 2213 4301969 YIL048W NEO1 SGTC_2320 7373003 200 µM 0.0889808259044677 0.465584144459589 no 1518 0.464548574189089 2159 5415828 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0876117656255456 0.466142677034033 no 1519 0.465092625262316 2243 2346 DNA damaging agent; causes G2/M arrest. SGTC_597 k018-0003 82.8 µM 0.0870417562042825 0.466375242277223 no 1520 0.465319160693328 2221 6786234 SGTC_1082 camptothecin 424.86 nM 0.0841021678422541 0.467574782095542 no 1521 0.466487600531938 2264 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1 0258-0098 57.368 µM 0.0839737591381792 0.467627187841464 no 1522 0.466538647617554 2151 6790032 YDR047W HEM12 SGTC_1194 1488-0194 225 µM 0.0832752335592033 0.467912277651169 no 1523 0.466816346318474 2175 1391452 SGTC_1325 1431-0015 227 µM 0.0824705212905576 0.468240725912596 no 1524 0.467136279532027 2109 1103340 SGTC_2023 5144124 124 µM 0.0821892042117771 0.468355552319879 no 1525 0.467248129095796 2209 2830192 SGTC_2992 9074591 71.4286 µM 0.0810010473492375 0.468840556367187 no 1526 0.467720559789635 2289 17741321 SGTC_2198 6589944 200 µM 0.0790121342399172 0.469652531185492 no 1527 0.468511485755708 2219 5290268 SGTC_458 nppb 133 µM 0.0786821691948929 0.469787251885615 no 1528 0.468642714212635 2265 4549 A chloride channel blocker. SGTC_2168 5727979 200 µM 0.0785081622832561 0.469858298177475 no 1529 0.468711918850806 2250 695210 SGTC_196 k015-0023 18.111 µM 0.0781344284177458 0.470010895387495 no 1530 0.468860560489997 2176 5211998 SGTC_594 1487-1584 10.8 µM 0.0779778388363354 0.470074832925016 no 1531 0.468922840676228 2225 5013332 SGTC_2852 9023854 51.95 µM 0.0771859059611743 0.470398201074541 no 1532 0.469237826804932 2237 19798528 SGTC_826 1683-5028 118 µM 0.0767333498794115 0.470583001049028 no 1533 0.4694178366887 2201 722377 SGTC_2147 5545932 89.7195 µM 0.0764690819565737 0.47069091702778 no 1534 0.469522955478123 2183 797404 SGTC_1922 5578187 25 µM 0.076048713892028 0.470862582214489 no 1535 0.469690171148964 2268 1350412 SGTC_2643 anethole 100 µM 0.0755002098045424 0.471086582287245 no 1536 0.469908365307436 2248 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2610 ononetin 44.17 µM 0.0748377867651134 0.471357117179916 no 1537 0.470171888305585 2199 259632 SGTC_1767 st044992 70.3 µM 0.0743810454335306 0.471543658958492 no 1538 0.470353595286064 2226 9600693 SGTC_3145 9085516 49.47 µM 0.0735894536907551 0.471866974726447 no 1539 0.470668531560465 2086 25236195 SGTC_405 ebelactone b 50 µM 0.0733265314360876 0.471974366152155 no 1540 0.47077313974603 2142 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_971 1315-0384 26.7 µM 0.0731893665076359 0.472030392409864 no 1541 0.470827713996126 2193 6769120 SGTC_537 1334-0398 209 µM 0.0715585988693296 0.472696536324142 no 1542 0.471476594441782 2296 5846986 SGTC_2814 7977482 42.97 µM 0.0706443550564207 0.473070024622684 no 1543 0.471840404171983 2249 6456762 SGTC_639 0833-0042 114 µM 0.0702798428726483 0.473218942324725 no 1544 0.471985462943988 2215 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1018 4259-0013 28.1 µM 0.0698565611440159 0.473391874415053 no 1545 0.472153913903403 2208 6801262 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.0687567526731367 0.473841225410922 no 1546 0.472591621472325 2298 6708630 An antioxidant. SGTC_2737 bleomycin 30.5 nM 0.0675512441761619 0.474333800698643 no 1547 0.473071434100094 2273 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3193 9111931 49.47 µM 0.0671299325925322 0.474505959481595 no 1548 0.473239132435974 2243 17087244 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0669907515350124 0.474562833500286 no 1549 0.473294532933751 2220 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1313 1220-0047 237 µM 0.064487615720314 0.475585785599579 no 1550 0.47429098390496 2224 3528706 SGTC_2085 5307070 144.047 µM 0.0636325582016298 0.475935257666124 no 1551 0.474631403285292 2247 2840351 SGTC_1912 st060209 90.8 µM 0.0620032222158386 0.476601237474128 no 1552 0.475280132991798 2224 688787 SGTC_1288 0973-0013 65.5 µM 0.0615307523510423 0.476794368568732 no 1553 0.475468261981663 2234 4315430 SGTC_1040 k898-0338 155 µM 0.0609498465902207 0.477031832376288 no 1554 0.475699575683916 2307 20969351 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0602982676222125 0.477298195818146 no 1555 0.475959040837265 2274 4620898 SGTC_1949 st076024 69.1 µM 0.0601492675313833 0.477359108017864 no 1556 0.476018375574957 2303 2921930 SGTC_2385 9074692 200 µM 0.0600454922798633 0.477401532323688 no 1557 0.4760597012152 2162 17046906 SGTC_759 3486-0358 89.3 µM 0.0593839251613508 0.477671993228672 no 1558 0.476323158162804 2311 875103 SGTC_3227 9130768 49.47 µM 0.0592920935392065 0.477709536514224 no 1559 0.476359729239467 2292 17720899 SGTC_3201 9113999 49.47 µM 0.0589305351394058 0.477857353423069 no 1560 0.476503718391657 2273 16649224 SGTC_2135 5326629 150.42 µM 0.0589003506793646 0.477869693956422 no 1561 0.476515739368282 2244 5020077 SGTC_653 0203-0016 55.2 µM 0.0580795051304015 0.478205294335136 no 1562 0.47684264968394 2254 295302 SGTC_840 0245-0196 390 µM 0.0572746434050016 0.47853437478056 no 1563 0.47716320940957 2267 3827528 SGTC_559 1550-0661 158 µM 0.0570289568532199 0.478634830538637 no 1564 0.47726106421902 2239 5830875 SGTC_744 1594-0068 283 µM 0.0570163780983282 0.478639973747885 no 1565 0.477266074264263 2290 668392 SGTC_2937 9044753 11.33 µM 0.0562642398637829 0.47894751493909 no 1566 0.477565653070993 2306 6465530 YGL099W LSG1 SGTC_3199 9111318 49.47 µM 0.0560700339211324 0.479026925692532 no 1567 0.477643007918719 2285 8548020 SGTC_300 r073-0011 5.04 µM 0.0552643973694954 0.47935635909923 no 1568 0.47796391279149 2316 2735780 SGTC_2444 5485484 36.41 µM 0.0551829376603728 0.479389669634756 no 1569 0.477996360997965 2277 6790631 SGTC_1914 st062367 72.6 µM 0.052630409327246 0.480433522235128 no 1570 0.479013193700442 2276 978205 SGTC_3165 9101544 49.47 µM 0.052441626599088 0.480510730063186 no 1571 0.479088403250326 2293 5002184 SGTC_466 geldanamycin 89.2 µM 0.0513637897202356 0.480951554668507 no 1572 0.479517819142379 2321 5288382 HSP90 inhibitor. SGTC_2001 4023502 57.655 µM 0.0505649137391831 0.481278302091532 no 1573 0.479836110911064 2287 108941 YCR052W RSC6 SGTC_1819 st053448 58.6 µM 0.0497675244522285 0.481604453986205 no 1574 0.480153823166327 2271 2857616 SGTC_1178 0988-0033 191 µM 0.0490612401618816 0.481893351979273 no 1575 0.480435246029536 2281 5392207 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0487161420800109 0.482034514105675 no 1576 0.480572755815014 2330 4000243 SGTC_2151 5563267 85.4165 µM 0.0480276172508611 0.482316161412747 no 1577 0.480847116307567 2248 5310824 SGTC_1465 k213-0056 144 µM 0.0468520402176073 0.482797062150049 no 1578 0.481315576223088 2211 24048857 YMR208W ERG12 SGTC_3100 9120536 49.47 µM 0.0465581970287107 0.482917270380447 no 1579 0.481432674907183 2339 16421196 SGTC_2883 9059145 45.46 µM 0.0457542497367117 0.483246164864146 no 1580 0.481753062006878 2309 16476510 SGTC_1902 st060212 70.5 µM 0.0443670369148677 0.483813699700601 no 1581 0.482305918247456 2339 688944 SGTC_1662 st014054 52 µM 0.0437662952407856 0.484059484653425 no 1582 0.482545346914557 2328 2838777 SGTC_2339 9000433 200 µM 0.0437241197958067 0.484076740368406 no 1583 0.482562156391385 2280 2988954 SGTC_406 estrone 100 µM 0.0433067655701095 0.484247498807513 no 1584 0.482728499069406 2333 5870 A steroid. SGTC_474 dl-dihydrosphingosine 5 µM 0.0426948563634088 0.484497863679328 no 1585 0.482972389930052 2312 3058739 A sphingolipid protein kinase C inhibitor. SGTC_382 3229-0966 23.2 µM 0.0422119141399684 0.48469546556228 no 1586 0.483164882458251 2314 5722370 SGTC_2667 digitoxin 100 µM 0.0419564805328197 0.484799980957075 no 1587 0.483266695524245 2341 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2621 lithochol-11-enic acid 100 µM 0.0415842921393764 0.484952270604083 no 1588 0.483415047733456 2329 6708711 SGTC_736 0958-0254 92.6 µM 0.0398831101091143 0.485648376905504 no 1589 0.484093158284682 2295 6812352 SGTC_2297 7971671 152.32 µM 0.0397228269785111 0.485713965411985 no 1590 0.484157051370044 2309 909016 SGTC_2560 caryophyllene 100 µM 0.0396463475604993 0.485745261236023 no 1591 0.484187538227643 2343 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1590 st077108 57.8 µM 0.0389147281476071 0.486044648577566 no 1592 0.484479187049966 2323 5489485 SGTC_1056 3448-1962 115 µM 0.0381878464002945 0.48634210500027 no 1593 0.484768955498234 2296 715507 SGTC_2539 epi(13)torulosol 80 µM 0.0365631979617196 0.487006975050323 no 1594 0.485416643834439 2303 6708597 SGTC_2854 9024559 71.43 µM 0.0361290378826703 0.487184656624873 no 1595 0.485589734277585 2308 3163529 SGTC_793 0488-0545 106 µM 0.0358663962710889 0.487292144886637 no 1596 0.485694445254645 2304 292548 SGTC_489 paxilline 115 µM 0.0350340594796556 0.487632791695388 no 1597 0.486026290998814 2247 105008 A toxic potassium channel blocker. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0348151816573853 0.487722372365138 no 1598 0.486113557379281 2304 5377381 SGTC_678 1218-2179 85.9 µM 0.0345499800118122 0.487830912930601 no 1599 0.486219293914838 2353 6820081 YOR116C RPO31 SGTC_1383 3049-0032 20.7 µM 0.0343930140623752 0.487895155690561 no 1600 0.486281877074252 2328 712864 SGTC_1245 0418-0076 17.2 µM 0.0333833869074883 0.488308381630952 no 1601 0.486684428803072 2305 6790114 SGTC_3171 9103192 49.47 µM 0.0329966335416105 0.488466677595781 no 1602 0.486838636112857 2340 13018434 SGTC_2487 5918373 44.05 µM 0.0329493174887974 0.488486043913771 no 1603 0.486857502228295 2356 2876279 SGTC_1149 3909-7961 23.3 µM 0.032945680352196 0.488487532583958 no 1604 0.486858952448516 2240 735261 SGTC_416 estradiol valerate 100 µM 0.032146578645947 0.488814606606091 no 1605 0.487177579099584 2281 13791 A steroid. SGTC_1370 2001-0092 44.6 µM 0.0314798403301969 0.489087509777863 no 1606 0.487443434631161 2323 790957 SGTC_2476 5806916 10.51 µM 0.0311791231270473 0.489210598246583 no 1607 0.487563344575058 2322 2870194 SGTC_788 1182-0090 188 µM 0.031061022349778 0.489258939107643 no 1608 0.487610437159293 2337 5715185 SGTC_3184 9108758 49.47 µM 0.0308089768143701 0.489362106594808 no 1609 0.487710940678543 2340 902885 SGTC_2751 anetholtrithion 17.25 µM 0.0296175479526755 0.48984979276085 no 1610 0.488186035105094 2333 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2853 9015042 58.44 µM 0.0293187538111956 0.489972100221834 no 1611 0.48830518497639 2342 6457456 SGTC_2595 hexamethylquercetagetin 100 µM 0.028633476019227 0.490252613236158 no 1612 0.488578456510526 2328 386331 SGTC_2019 4016004 108 µM 0.0285797142273967 0.490274620403848 no 1613 0.488599895588362 2321 45595336 SGTC_354 2783-3500 4.88 µM 0.0282583511474753 0.490406169669927 no 1614 0.48872804914624 2338 6740761 SGTC_2101 5377231 179.231 µM 0.026480239839521 0.491134054072051 no 1615 0.489437147198127 2329 2844213 SGTC_1051 3253-3903 78 µM 0.0264164526924272 0.491160166425303 no 1616 0.489462585689185 2353 5509239 SGTC_2402 5553605 200 µM 0.0263518278992746 0.491186621721845 no 1617 0.489488358279526 2341 6758546 SGTC_3309 9129340 25.759 µM 0.0262562872277854 0.491225733048328 no 1618 0.489526460309123 2313 17158987 SGTC_2409 alverine citrate 63.97 µM 0.0258817364140982 0.491379063104808 no 1619 0.489675833698781 2309 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_743 1275-0778 158 µM 0.0256008657520435 0.491494044107163 no 1620 0.489787847763606 2353 2849257 YMR203W TOM40 SGTC_2493 resveratrol 26.09 µM 0.0249915978002267 0.491743464669871 no 1621 0.490030832750518 2358 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_749 1000-0129 128 µM 0.0244946563170462 0.491946903703691 no 1622 0.490229023039458 2353 708470 SGTC_991 3996-0057 64.7 µM 0.0244762812686924 0.491954426163235 no 1623 0.490236351425997 2348 715343 SGTC_2588 indole-3-carbinol 100 µM 0.0241706614166993 0.492079542603751 no 1624 0.490358240044321 2363 3712 Induces cell cycle arrest. SGTC_1166 k206-0078 225 µM 0.0238895454673457 0.492194628181772 no 1625 0.490470356706519 2368 5404595 SGTC_3230 9131665 49.47 µM 0.023791097195576 0.492234931905585 no 1626 0.490509620724892 2364 15943720 SGTC_1736 st036774 51 µM 0.0233784872762229 0.492403851078695 no 1627 0.490674182491385 2368 1272247 SGTC_642 0335-0876 158 µM 0.0230067437072997 0.492556041064902 no 1628 0.490822446836776 2354 6812350 SGTC_2804 7954240 19.48 µM 0.0229763467110525 0.492568485493678 no 1629 0.490834570279059 2349 828705 SGTC_2713 st079149 53.4 µM 0.0219387133663252 0.492993293377962 no 1630 0.491248421699056 2342 3103253 SGTC_1978 st071761 42 µM 0.0215387051172979 0.493157059209307 no 1631 0.491407964198967 2267 5147680 SGTC_162 k030-0015 37.8 µM 0.0212071075360615 0.493292818169063 no 1632 0.491540222282324 2366 1809920 YMR134W ERG29 SGTC_1050 3232-1156 69.3 µM 0.0204759293503449 0.493592171657645 no 1633 0.491831856823254 2339 700529 SGTC_2365 9042475 200 µM 0.0197090142978512 0.493906160140702 no 1634 0.492137749903789 2350 6464479 SGTC_361 000s-0510 1.45 µM 0.0190708692001131 0.494167430830267 no 1635 0.492392285106712 2348 660 SGTC_1788 fluconazole 20 µM 0.0170552193301727 0.494992698283716 no 1636 0.493196281754108 2289 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2468 5987765 72.9 µM 0.0170433978553123 0.494997538416405 no 1637 0.493200997154863 2307 26772094 SGTC_1781 st038725 66.3 µM 0.0167966905647051 0.495098549331691 no 1638 0.493299405036219 2361 4270275 YIL048W NEO1 SGTC_1125 tnp00248 1.32998 µM 0.0167523144424769 0.495116718559627 no 1639 0.493317106057048 2380 24207736 SGTC_1700 st030840 7.9285 µM 0.0167336455411665 0.495124362302267 no 1640 0.493324552827269 2371 5499307 SGTC_2975 9084847 53.72 µM 0.0161986742755265 0.495343400187813 no 1641 0.493537946550236 2277 27211724 SGTC_2393 9031399 185.94 µM 0.0159934714114137 0.495427418537147 no 1642 0.493619800044512 2364 1526623 YDL150W RPC53 SGTC_299 1273-0059 1.44 µM 0.0159384545290826 0.495449944707851 no 1643 0.49364174580771 2375 2848077 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0159026347616751 0.495464610799245 no 1644 0.493656034016516 2380 77254 SGTC_99 0109-0120 622.8 µM 0.0158378720050491 0.49549112736072 no 1645 0.493681867364863 2380 759414 SGTC_1954 st077032 68.9 µM 0.0153815860793587 0.495677950321355 no 1646 0.493863876935086 2253 698907 SGTC_2803 7707263 71.43 µM 0.015320717751973 0.495702872488787 no 1647 0.493888157023348 2378 2199229 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0144963859469082 0.49604039175763 no 1648 0.49421698127908 2374 75037 A free radical scavenger. SGTC_1487 3970-0795 2.82 µM 0.0129927237361655 0.496656067198099 no 1649 0.494816798994591 2348 3765103 SGTC_1712 st032288 53.4 µM 0.0128904163171021 0.496697957341295 no 1650 0.494857610331865 2368 2883011 SGTC_1068 loratadine 26.9 µM 0.012727923946793 0.49676449050536 no 1651 0.494922430090689 2357 3957 A H1 histamine antagonist. SGTC_3006 9075424 71.4286 µM 0.0126389580678476 0.496800917985758 no 1652 0.494957919486603 2368 7465181 SGTC_1153 4055-0057 267 µM 0.0115558313598279 0.49724441115005 no 1653 0.495389992886874 2373 882706 SGTC_3168 9103419 49.47 µM 0.0105292797351375 0.49766474243647 no 1654 0.495799502746823 2391 16649256 SGTC_702 1488-0190 94 µM 0.00971698387121943 0.497997346532474 no 1655 0.496123545298218 2389 949357 SGTC_2618 avocadyne 43.43 µM 0.00929038343535575 0.498172023670928 no 1656 0.496293726562072 2379 3015189 SGTC_3095 9117207 49.47 µM 0.0092291307962479 0.498197104396196 no 1657 0.496318161781996 2393 17015229 SGTC_326 k292-0812 17.5 µM 0.00808097712646861 0.49866723272538 no 1658 0.496776191644291 2397 3579357 SGTC_368 fentichlor 4.58 µM 0.00790290573847529 0.498740146844436 no 1659 0.496847229581125 2383 7329 A pesticide. SGTC_767 0929-0023 86 µM 0.00728111645411085 0.498994748520564 no 1660 0.497095280463403 2387 1204563 SGTC_2664 lyso-paf C-16 73.48 µM 0.00722014416213404 0.49901971463509 no 1661 0.497119604249223 2395 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3188 9110789 49.47 µM 0.00636497165450437 0.49936987953804 no 1662 0.497460760838782 2388 849217 SGTC_2404 5161160 200 µM 0.00529748414662687 0.499806981072547 no 1663 0.497886619478911 2392 2831543 SGTC_1041 0206-0046 107 µM 0.00482609439925857 0.5 no 1664 0.498074674368783 2364 50494 SGTC_2183 6420625 130.508 µM 0.00476273909391515 0.499974058040883 no 1665 0.498099949188278 2392 2897619 SGTC_782 0083-0095 30.5 µM 0.00302572804383987 0.499262808322246 no 1666 0.498792910996139 2396 3591729 An indicator and reagent. SGTC_3062 9077494 49.47 µM 0.0026019943900333 0.499089303395697 no 1667 0.498961955595773 2380 16459633 SGTC_1213 1315-0166 115 µM 0.00253414576201359 0.499061521640112 no 1668 0.498989023192897 2395 768401 SGTC_1413 3910-0535 34.4 µM 0.00251621395751798 0.499054179163587 no 1669 0.498996176925066 2400 2876951 SGTC_2087 5276107 200 µM 0.00105400176387793 0.498455453288314 no 1670 0.499579514210626 2402 144405 SGTC_1073 triclabendazole 3.09 µM 0.000862914775962123 0.498377209931444 no 1671 0.499655746854209 2399 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.00028751163565317 0.498141603104542 no 1672 0.499885299454011 2402 165521 SGTC_2703 st077852 53.4 µM 0.00026976647155332 0.498134337109924 no 1673 0.499892378749968 2405 6281836 SGTC_1616 st002734 56.1 µM -0.000421138770835485 0.49785143722879 no 1674 0.499831989943364 2407 4026101 SGTC_861 0443-0273 110 µM -0.00109639310525698 0.497574946852639 no 1675 0.499562602522003 2420 6149169 SGTC_2798 7813637 45.45 µM -0.00220463721190331 0.497121166598415 no 1676 0.499120477715701 2421 956368 SGTC_2593 nobiletin 86.24 µM -0.00301054607225957 0.496791182463934 no 1677 0.498798967698916 2412 72344 An anti-infammatory. SGTC_1692 fluoroquinolonic acid 71 µM -0.00319016133579537 0.496717638226487 no 1678 0.498727311920568 2428 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3085 9117376 49.47 µM -0.00328383163139415 0.496679284567645 no 1679 0.498689943075028 2418 16480349 SGTC_1024 4507-0395 26 µM -0.00367779415571395 0.496517975453647 no 1680 0.498532775720327 2441 4201836 SGTC_2913 7966556 36.57 µM -0.00371193207353165 0.496503997609242 no 1681 0.498519156754509 2412 2976516 SGTC_1243 0416-0003 5.65 µM -0.00526835746015923 0.495866720692421 no 1682 0.497898239183481 2416 2141977 SGTC_1714 st033236 13.627 µM -0.0055380384699358 0.495756301082123 no 1683 0.497790653597253 2429 2916566 SGTC_2342 7990637 118.86 µM -0.00566781820096525 0.495703163502182 no 1684 0.497738879788112 2418 2033102 YER133W GLC7 SGTC_1080 nisoldipine 24.4 µM -0.00607862296233318 0.495534962313406 no 1685 0.497574995227565 2416 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2680 butyl paraben 22.24 µM -0.00679145077453065 0.495243101761352 no 1686 0.497290623968579 2414 7184 An antifungal and steroid mimetic. SGTC_418 lividomycin a 100 µM -0.00705440093426467 0.495135439959814 no 1687 0.497185724546307 2416 72394 An antibiotic. SGTC_2839 9003951 25.97 µM -0.00780256402680662 0.494829115484213 no 1688 0.496887258898149 2415 2990634 SGTC_879 0831-1030 162 µM -0.00866571905564065 0.49447571303543 no 1689 0.496542921546716 2430 1549252 SGTC_1117 retinoic acid 1.10837 µM -0.00890374456864316 0.494378258756366 no 1690 0.496447966769962 2419 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2965 9082772 38.63 µM -0.00965713105781882 0.494069803569212 no 1691 0.496147421995771 2431 16459634 SGTC_1285 0929-0069 65.5 µM -0.0103444822202648 0.493788387977399 no 1692 0.495873222273527 2432 1206237 SGTC_2350 9023895 38.85 µM -0.0106319847198907 0.493670679496235 no 1693 0.49575853167943 2435 2997209 SGTC_1228 0124-0032 52.5 µM -0.0125679442614045 0.492878079134833 no 1694 0.494986247646469 2440 X1228 SGTC_203 k066-0004 30.888 µM -0.0126264268561115 0.492854136222716 no 1695 0.494962918317904 2417 6795412 SGTC_3327 9140648 26.9345 µM -0.0137413340074615 0.492397695629982 no 1696 0.494518173392824 2435 8029710 SGTC_1472 k841-0093 193 µM -0.0155402660391764 0.491661237965844 no 1697 0.493800580355795 2475 X1472 SGTC_215 1287-0124 461.5 µM -0.0162465218469074 0.491372114327397 no 1698 0.493518860642609 2486 5560863 SGTC_123 0083-0120 66.675 µM -0.0169100356781719 0.491100492322639 no 1699 0.493254193299537 2440 16001701 SGTC_978 1416-0512 87.4 µM -0.0191337350574433 0.490190209504711 no 1700 0.492367209833609 2453 6814003 SGTC_2567 aureobasidin a 60 nM -0.0209897631827832 0.489430473730262 no 1701 0.491626910837492 2500 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_820 1582-0060 59.9 µM -0.0216055963321552 0.489178400502461 no 1702 0.491381284673661 2452 3848840 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0218877874708099 0.489062895278931 no 1703 0.491268733314633 2459 4213774 SGTC_934 2950-0684 338 µM -0.0223227314035325 0.488884867760062 no 1704 0.491095258180472 2440 1121253 SGTC_1259 0671-0132 43 µM -0.0231801881699015 0.488533907433125 no 1705 0.49075327095592 2468 X1259 SGTC_235 0330-0087 5 mM -0.0233054305630814 0.488482645980258 no 1706 0.490703319964303 2453 46494818 YHR062C RPP1 SGTC_2251 lansoprazole 556 µM -0.0251912746995963 0.48771079735102 no 1707 0.489951198265165 2464 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2894 9048625 32.47 µM -0.0260547847269588 0.487357390420621 no 1708 0.489606820683721 2451 4092861 SGTC_679 0422-0091 41.4 µM -0.0263034489451015 0.487255621968582 no 1709 0.489507652001997 2451 627384 YHR062C RPP1 SGTC_317 4495-0002 170 µM -0.0264764454372681 0.487184821820002 no 1710 0.489438660415061 2488 15991618 SGTC_1453 4237-0541 195 µM -0.027794817501102 0.486645281314604 no 1711 0.488912899701176 2454 739892 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0279894490275745 0.486565630890863 no 1712 0.488835283153877 2463 6728940 SGTC_925 2064-1272 59.6 µM -0.0290876222180287 0.486116227913755 no 1713 0.488397353830649 2487 6815817 SGTC_1996 st072960 66.8 µM -0.0293898656502609 0.485992544574807 no 1714 0.488276827677183 2441 1719405 SGTC_3106 9121286 49.47 µM -0.0294520678846469 0.485967090491096 no 1715 0.488252023313524 2578 15943471 SGTC_2167 5876490 200 µM -0.0298181873865847 0.485817270082565 no 1716 0.488106026889422 2555 686534 SGTC_2068 5226020 147 µM -0.0309400722400548 0.485358194154949 no 1717 0.487658666091462 2475 1810509 SGTC_1335 1486-0900 202 µM -0.032428795110877 0.484749037962001 no 1718 0.487065049690819 2464 X1335 SGTC_2612 dictamnine 15.46 µM -0.033684686376483 0.484235179512946 no 1719 0.486564295272252 2497 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_119 0121-0043 24.815 µM -0.0352335362546658 0.483601490734783 no 1720 0.485946760380238 2468 1092378 SGTC_294 k038-0071 157 µM -0.0356911177938979 0.483414285941061 no 1721 0.485764326507459 2501 24152826 SGTC_3250 9135583 49.47 µM -0.0359232990587627 0.483319297827649 no 1722 0.485671758946456 2538 7699353 SGTC_745 0469-0705 296 µM -0.0367570861089917 0.482978193484221 no 1723 0.485339345615491 2485 3486736 SGTC_312 4092-0653 6.84 µM -0.0375235962308815 0.482664623283893 no 1724 0.485033763160661 2552 1148278 SGTC_3161 9100388 49.47 µM -0.037564590009319 0.482647853515657 no 1725 0.485017420531219 2471 25236368 SGTC_2132 5317594 122.667 µM -0.0380418721981516 0.482452608796727 no 1726 0.48482714849419 2485 794577 SGTC_1942 st076330 65.2 µM -0.0380508173945978 0.482448949571007 no 1727 0.484823582459017 2560 24208414 SGTC_3014 9081533 49.47 µM -0.0383703919132757 0.482318221687281 no 1728 0.484696183710566 2481 21367265 SGTC_630 4356-0227 183 µM -0.0408267281213778 0.481313476313696 no 1729 0.483717015579578 2470 779312 SGTC_3112 9123419 49.47 µM -0.0410318073027008 0.481229595537119 no 1730 0.483635269323012 2482 17015854 SGTC_380 3970-0968 6 µM -0.0416781234142877 0.480965247013168 no 1731 0.483377646895502 2484 2891601 SGTC_2303 7774051 200 µM -0.0423942203378892 0.480672367351188 no 1732 0.483092217855571 2519 2953184 SGTC_318 1488-0629 67.2 µM -0.0424931365713974 0.480631911977941 no 1733 0.483052791516422 2533 3662576 SGTC_2948 9070189 9.45 µM -0.0426891842662919 0.480551731768473 no 1734 0.482974650708214 2498 6473636 YDL196W YDL196W SGTC_1883 5-benzylidenerhodanine 20 µM -0.0437157924566271 0.480131879209995 no 1735 0.482565475345569 2489 1273210 SGTC_395 anisomycin 6.25 µM -0.0447765483566107 0.479698084400564 no 1736 0.482142709020094 2534 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_648 0375-0473 33.3 µM -0.0449570195576638 0.479624283306019 no 1737 0.482070783857836 2494 1713139 SGTC_3025 9087895 49.47 µM -0.0468361438151217 0.478855884517571 no 1738 0.481321911015894 2503 17173641 SGTC_1461 k072-0203 53.8 µM -0.0474886030295332 0.478589103539998 no 1739 0.481061906776835 2469 5418714 SGTC_1078 idebenone 36.1 µM -0.0476598057670666 0.478519102842296 no 1740 0.480993684014553 2527 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1649 st011737 51.3 µM -0.0482665960928379 0.478271006166538 no 1741 0.480751887984077 2514 1761035 SGTC_2232 chlorophetanol 41.5365 µM -0.049858814242666 0.477620040633271 no 1742 0.480117448965766 2509 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3197 9113331 49.47 µM -0.0499489888487588 0.477583175243935 no 1743 0.480081519270302 2530 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2690 usnic acid 100 µM -0.0503167654023236 0.477432821979519 no 1744 0.479934981916481 2542 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2769 toremifene 3.73 µM -0.0506185530817725 0.477309448479371 no 1745 0.479814739277522 2577 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2634 4'-methoxyflavone 100 µM -0.0512040221730048 0.477070109695454 no 1746 0.479581473410272 2518 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2504 purpurogallin 52.29 µM -0.0513308223164273 0.477018275095856 no 1747 0.47953095390701 2537 5281571 An antioxidant. SGTC_1354 1498-1681 81 µM -0.051438993982228 0.476974055934373 no 1748 0.479487856590842 2549 5754243 SGTC_331 k048-0133 24.5 µM -0.0518600937135946 0.476801918579688 no 1749 0.479320086032974 2493 6813582 SGTC_731 3966-0296 387 µM -0.0518726954244121 0.476796767312708 no 1750 0.47931506543528 2510 660956 SGTC_2253 7938677 135.83 µM -0.0519055300726263 0.476783345340718 no 1751 0.479301983928553 2585 2301972 SGTC_1028 k015-0029 4.8 µM -0.0545013529144032 0.475722323355747 no 1752 0.478267865361874 2511 4588309 SGTC_593 1203-0218 61.7 µM -0.0553475488544859 0.475376484316723 no 1753 0.477930790843106 2528 3666956 SGTC_1161 k007-0610 110 µM -0.0561807041522924 0.475035993091782 no 1754 0.477598926368754 2507 5843850 SGTC_876 0720-0963 56.8 µM -0.0570029966255424 0.474699959126259 no 1755 0.477271404031341 2495 765861 SGTC_3090 9117696 49.47 µM -0.0572147261472884 0.474613437693679 no 1756 0.477187073803683 2616 7923821 SGTC_134 0269-0018 6.916 µM -0.0574508140609943 0.474516963827512 no 1757 0.477093043022076 2570 4378915 SGTC_471 1-acyl-paf 4 µM -0.0577315030435031 0.474402266333014 no 1758 0.476981249867987 2503 16759367 SGTC_1983 st071813 46.9 µM -0.0587026633550413 0.474005439062118 no 1759 0.476594468973985 2566 11838595 SGTC_1089 terbinafine 2.25 µM -0.0587725662571369 0.473976876922819 no 1760 0.47656662981631 2538 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1525 8-methoxypsoralen 92.5 µM -0.0589013454778847 0.473924258427121 no 1761 0.476515343188923 2530 4114 Related to psoralen; DNA damaging agent. SGTC_1048 3161-0300 24.5 µM -0.0591912156850849 0.473805820688173 no 1762 0.476399903122126 2519 2165101 SGTC_2651 TUB2.036 5 µM -0.0606027040976986 0.473229135517977 no 1763 0.475837809963089 2563 15992207 YFL037W TUB2 SGTC_59 0330-0160 1.33 µM -0.0607842896542735 0.473154950010317 no 1764 0.475765501111964 2536 4293482 SGTC_1094 duloxetine 25.4 µM -0.0630499559701299 0.472229407010159 no 1765 0.474863362154963 2497 60834 A selective serotonin reuptake inhibitor. SGTC_1515 3460-0031 42.1 µM -0.063590875222797 0.472008459107931 no 1766 0.474647998777512 2535 2876596 SGTC_2851 9015922 71.43 µM -0.0660900144492741 0.470987755002366 no 1767 0.473653080393011 2586 2996893 SGTC_3103 9120822 49.47 µM -0.0661226551770022 0.470974425048484 no 1768 0.473640087048464 2542 17141819 SGTC_1323 1348-1351 11.2 µM -0.0668715303494146 0.470668605304771 no 1769 0.473341988890177 2528 6989654 SGTC_2426 5582046 32.21 µM -0.0686403139075939 0.469946352409284 no 1770 0.472637964332526 2590 2251934 SGTC_633 0437-0093 97.7 µM -0.0687831632575876 0.469888026572599 no 1771 0.4725811100588 2513 2831118 SGTC_2370 9071495 200 µM -0.0699356841390876 0.469417472431434 no 1772 0.472122425407366 2585 21791103 SGTC_2305 7443522 69.23 µM -0.070160430421236 0.469325717406791 no 1773 0.472032984314297 2556 5415886 SGTC_2011 4012611 177 µM -0.0713081271991854 0.468857183674525 no 1774 0.471576263564035 2538 2049887 SGTC_1144 3486-0183 12.5 µM -0.0714552309158635 0.468797133414141 no 1775 0.471517726994016 2564 6744069 SGTC_338 4055-0136 114 µM -0.0719224684681456 0.468606403745507 no 1776 0.471331804550249 2533 2900563 SGTC_2188 6126565 140.678 µM -0.0720759839202361 0.468543739224199 no 1777 0.471270719280758 2543 874518 SGTC_2120 5538279 151.968 µM -0.0721615304910319 0.468508819723006 no 1778 0.471236679773636 2558 2058197 SGTC_1289 0976-0073 69.1 µM -0.0727660696674501 0.468262058055924 no 1779 0.470996135917621 2636 3391136 SGTC_1103 duloxetine 36.1 µM -0.0743235974627035 0.467626360534189 no 1780 0.470376450448427 2679 60835 A selective serotonin reuptake inhibitor. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0747883713048643 0.467436681232255 no 1781 0.470191547129742 2604 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_75 0159-0059 199.013 µM -0.0759027356825222 0.466981927106486 no 1782 0.469748240190338 2555 5377270 SGTC_993 3909-8757 62.7 µM -0.0763007092809433 0.466819530913935 no 1783 0.469589930783125 2590 4288324 YLR208W SEC13 SGTC_2707 st078556 66.6 µM -0.0763077952397542 0.466816639483825 no 1784 0.469587112112143 2574 17250899 SGTC_1371 2421-0008 32.7 µM -0.0765904757047037 0.466701292965907 no 1785 0.469474667991939 2597 2827552 SGTC_80 0159-0065 512.242 µM -0.0767433649535742 0.466638908346398 no 1786 0.469413852998988 2525 1548079 SGTC_1838 st055369 84.5 µM -0.0777349786367761 0.466234312271214 no 1787 0.469019434675649 2529 676036 SGTC_2071 5230951 39.92 µM -0.0778873530522546 0.466172143873469 no 1788 0.46895882982529 2549 1799272 SGTC_205 1486-1330 71.903 µM -0.0789766986698938 0.465727717596407 no 1789 0.468525578464073 2535 4118834 SGTC_226 1,3-diallylurea 8.28947 mM -0.0792878478189088 0.465600784202919 no 1790 0.468401835953314 2641 74537 YKL182W FAS1 SGTC_1699 st031318 29.054 µM -0.079444330450263 0.465536948385894 no 1791 0.468339604721073 2616 5340658 SGTC_766 1391-0721 126 µM -0.0805778833480717 0.465074551279374 no 1792 0.467888827765672 2589 1020919 YIL115C NUP159 SGTC_3342 9147791 14.508 µM -0.0811553957357722 0.464838991431916 no 1793 0.467659185750865 2543 1838168 SGTC_3131 9127911 49.47 µM -0.0829677600776513 0.464099831803809 no 1794 0.466938587466377 2720 45595681 SGTC_18 0111-0177 500 nM -0.083899099230468 0.463720039927375 no 1795 0.466568327873502 2552 721752 SGTC_2988 9073640 71.4286 µM -0.0850437691527861 0.463253298970382 no 1796 0.466113296987501 2653 9102229 SGTC_127 0180-0333 59.125 µM -0.085750751399345 0.462965051075723 no 1797 0.465832278444995 2545 771601 SGTC_2008 4012253 172 µM -0.0870565714737728 0.462432698720905 no 1798 0.465313272606902 2586 603940 SGTC_1026 k007-1105 30.6 µM -0.0872511255283073 0.462353389311548 no 1799 0.46523595098672 2551 7066794 SGTC_646 4092-0839 27.3 µM -0.0880723629349184 0.462018630738387 no 1800 0.464909581092342 2638 877796 SGTC_760 0568-0725 82.9 µM -0.0881040145142339 0.462005729235722 no 1801 0.46489700283458 2629 3916171 SGTC_3200 9114385 49.47 µM -0.0889478311208187 0.461661795866082 no 1802 0.464561685215916 2635 17018030 YLR208W SEC13 SGTC_2947 9072639 7.68 µM -0.0911392728553461 0.460768715065575 no 1803 0.463690963627223 2635 16488146 SGTC_311 1315-0136 58 µM -0.091167667688136 0.460757144574967 no 1804 0.463679682691759 2692 6759207 SGTC_1017 4239-0030 168 µM -0.0913825761802886 0.460669573498273 no 1805 0.463594303005168 2599 1149593 SGTC_922 1866-0035 480 µM -0.0925071330888358 0.460211369390638 no 1806 0.463147562069478 2579 3156169 SGTC_94 0334-0113 514.748 µM -0.0929384953714273 0.460035623512774 no 1807 0.462976211598173 2575 6795178 SGTC_3021 9087658 49.47 µM -0.0931349653875986 0.459955580167702 no 1808 0.462898169891962 2575 25237042 SGTC_305 1682-2595 20.8 µM -0.0933844007214372 0.459853960697031 no 1809 0.462799091390639 2625 226033 SGTC_1552 6-methylflavone 10.6 µM -0.0934388684642493 0.45983177099299 no 1810 0.46277745650146 2578 689013 SGTC_1774 st048371 48.465 µM -0.0951889795076082 0.459118857327611 no 1811 0.462082361658856 2581 4242727 SGTC_2316 5844804 197.44 µM -0.0957452302506101 0.458892294122303 no 1812 0.461861458670334 2650 776813 SGTC_2461 5755302 26.15 µM -0.0957682985451874 0.458882898599298 no 1813 0.461852297848144 2703 2788904 SGTC_190 3970-0790 3.722 µM -0.0981935575796339 0.457895240077214 no 1814 0.460889299024915 2555 2832352 SGTC_780 0109-0199 192 µM -0.0988995490287361 0.457607781850407 no 1815 0.460609013487421 2722 610414 SGTC_2363 9053361 176 µM -0.0989725994093099 0.45757803922259 no 1816 0.460580012883892 2681 6469797 YMR079W SEC14 SGTC_910 3454-3003 490 µM -0.0989974613972128 0.457567916662115 no 1817 0.460570142857815 2572 820824 SGTC_2348 9022543 33.42 µM -0.10056681630502 0.456929009658628 no 1818 0.459947169935329 2680 3162678 YDL140C RPO21 SGTC_2060 5238662 140 µM -0.102093111923412 0.456307739473242 no 1819 0.459341384168131 2678 790130 SGTC_1889 st059080 5.18 µM -0.103892392538705 0.455575489526981 no 1820 0.458627372156181 2573 176925 Isolated from Daphnopsis sellowiana. SGTC_656 4090-1979 187 µM -0.104471986251645 0.45533964534287 no 1821 0.458397399169732 2610 22330961 SGTC_2108 5365811 200 µM -0.104588638265814 0.45529218002828 no 1822 0.458351115303529 2666 780283 SGTC_293 4049-0273 38.5 µM -0.105248773896523 0.455023585091599 no 1823 0.458089204815569 2600 1380311 SGTC_2951 9072950 58.06 µM -0.105466117893593 0.454935157004345 no 1824 0.458002977009016 2578 16488155 SGTC_996 3970-0799 1.8 µM -0.105562752265498 0.454895841279153 no 1825 0.45796463947897 2628 6615648 YGL040C HEM2 SGTC_2124 5246320 200 µM -0.105918888777036 0.454750950842739 no 1826 0.457823353646687 2674 579342 SGTC_1126 isoteolin 1.0172 µM -0.106142380345377 0.45466002869518 no 1827 0.457734693196693 2612 133323 SGTC_170 4197-0004 226 µM -0.106172606634924 0.454647732041457 no 1828 0.457722702407108 2711 218692 SGTC_2589 lobaric acid 100 µM -0.107263933001391 0.454203788047959 no 1829 0.457289798357672 2649 73157 A novel microtubule depolymerizer. SGTC_2235 salicylic acid 500 µM -0.107445343652013 0.454129996984257 no 1830 0.457217841826305 2598 338 A COX inhibitor and kinase inhibitor. SGTC_907 3448-6986 75.5 µM -0.11291490853416 0.451905937674675 no 1831 0.455049008311208 2682 590582 SGTC_560 2332-1943 155 µM -0.113282065481368 0.451756695904125 no 1832 0.454903467689728 2596 21177716 SGTC_730 1436-0052 41.2 µM -0.113516660617053 0.45166134136021 no 1833 0.454810477596946 2607 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1268 0828-0275 2.46 µM -0.114116241153928 0.451417645971478 no 1834 0.454572823874789 2703 745337 SGTC_2029 5175081 200 µM -0.114492497203399 0.451264728629244 no 1835 0.454423696827227 2600 1380876 SGTC_1548 st061468 90.8 µM -0.115889490458906 0.450697028463357 no 1836 0.453870062485729 2666 390799 SGTC_2041 5107442 45.335 µM -0.11596110707436 0.450667928121064 no 1837 0.453841682923803 2657 793005 SGTC_1648 st011736 69.8 µM -0.116266385485077 0.450543885773717 no 1838 0.45372071269841 2727 2855514 SGTC_2716 st080858 38.6235 µM -0.116475170812064 0.450459053790149 no 1839 0.45363798148448 2662 5296050 SGTC_801 0866-0028 10.1 µM -0.11679898265747 0.450327489630472 no 1840 0.453509674978211 2606 6849771 SGTC_2728 chlorpromazine 9.18 µM -0.116878032857686 0.450295372507281 no 1841 0.453478353034012 2596 2726 A thorazine and dopamine antagonist. SGTC_1745 st081495 74 µM -0.11709338815913 0.450207877951373 no 1842 0.453393024589299 2632 13842402 YBL026W LSM2 SGTC_2299 7976368 114.88 µM -0.118261913973697 0.449733171560669 no 1843 0.452930066911299 2699 2979718 SGTC_778 3456-2434 196 µM -0.118753684502447 0.449533414287115 no 1844 0.452735251673618 2790 5539063 SGTC_149 3970-0822 46.1 µM -0.120387516836864 0.448869843412736 no 1845 0.452088089801129 2604 3114250 YBL034C STU1 SGTC_232 clozapine 119 µM -0.121515602329084 0.448411761822733 no 1846 0.45164132870337 2619 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_131 0141-0277 33.849 µM -0.12167844502205 0.448345641968911 no 1847 0.4515768423769 2746 1547771 SGTC_1476 4112-3294 3.34 µM -0.122959692033924 0.447825460877283 no 1848 0.451069508392611 2734 704369 SGTC_1989 st071868 50.2 µM -0.123060839767158 0.447784399116877 no 1849 0.451029460427759 2711 16414057 SGTC_3301 9125354 19.7965 µM -0.124247515510638 0.447302700173304 no 1850 0.450559650870466 2623 41905162 SGTC_1173 0443-0020 122 µM -0.125246859596167 0.446897103708613 no 1851 0.450164060346956 2656 5331295 SGTC_631 k072-0230 41.5 µM -0.126662816568936 0.446322514815082 no 1852 0.449603638408643 2728 5773147 SGTC_691 1548-0686 185 µM -0.127487912400976 0.445987746569843 no 1853 0.449277119812084 2646 46495133 SGTC_2692 st077426 47.7 µM -0.127570618022306 0.445954192325303 no 1854 0.449244392263681 2695 25238571 SGTC_55 0767-0285 6.563 µM -0.127863323272631 0.445835442884473 no 1855 0.449128568265472 2666 3116166 SGTC_1733 st037357 54.9 µM -0.128929844995092 0.445402800136003 no 1856 0.448706580431375 2625 1272339 YGL099W LSG1 SGTC_3277 9138724 49.47 µM -0.129045085745414 0.445356055721216 no 1857 0.448660986892994 2702 15943418 SGTC_2833 9001315 45.46 µM -0.129412328189998 0.445207098440775 no 1858 0.44851569661277 2694 2989378 SGTC_1499 4480-0877 67.3 µM -0.129869168993893 0.445021809951402 no 1859 0.448334968624027 2637 2861909 SGTC_556 4058-0063 51.5 µM -0.131454848019741 0.444378773303001 no 1860 0.44770775130266 2655 6615692 SGTC_1353 1498-1206 8.11 µM -0.13222390662595 0.444066951400729 no 1861 0.447403596190268 2637 6756808 SGTC_2586 curcumin 80 µM -0.133996322676096 0.443348441126323 no 1862 0.446702741145752 2737 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2131 toluylene red 5.2905 µM -0.13575242155699 0.442636729229149 no 1863 0.446008502427752 2677 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1063 disulfiram 1.84 µM -0.137680246099828 0.441855633527532 no 1864 0.445246566015936 2631 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_39 0986-0283 58.349 µM -0.138490554343289 0.44152738863967 no 1865 0.44492636711317 2732 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_810 3825-7150 143 µM -0.139132724351424 0.441267282782501 no 1866 0.444672634706877 2682 22330411 YGL099W LSG1 SGTC_2778 tioconazole 65.09 nM -0.139343813766713 0.441181788219036 no 1867 0.444589234596733 2627 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_358 0075-0058 9.45 µM -0.13996585242302 0.440929868644352 no 1868 0.444343485286068 2580 1069125 SGTC_378 3970-0959 8.33 µM -0.139981907054564 0.440923366991502 no 1869 0.444337142852737 2764 6615653 SGTC_258 haloperidol 50.781 µM -0.140705995335722 0.440630149147973 no 1870 0.444051104313787 2679 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_528 3492-0019 172 µM -0.140907652327958 0.440548494411941 no 1871 0.443971448392084 2647 2869262 SGTC_1920 st075728 45.7 µM -0.142201388973562 0.440024696217361 no 1872 0.443460467348906 2742 3400306 SGTC_107 0358-0022 2.6945 µM -0.142634946442057 0.439849184220738 no 1873 0.443289248193256 2730 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2270 7924575 90.91 µM -0.143063669271658 0.43967564099779 no 1874 0.443119948729419 2880 1262135 SGTC_503 tyrphostin 8 294 µM -0.143680650991251 0.439425912587281 no 1875 0.442876325458941 2677 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1101 ebselen 5.29 µM -0.143937339547183 0.439322022883806 no 1876 0.442774974994449 2685 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3334 9142812 21.919 µM -0.144075965780247 0.439265918348081 no 1877 0.442720241609652 2783 45283678 SGTC_1315 1237-0019 3.69 µM -0.145729052643782 0.438596978619275 no 1878 0.442067642752981 2744 825140 SGTC_357 1325-0123 420 µM -0.145902339647697 0.438526866255104 no 1879 0.441999242292346 2718 1098503 SGTC_2718 lomofungin 53.02 µM -0.146235052723287 0.438392255105081 no 1880 0.441867917456879 2784 5351222 A RNA synthesis inhibitor. SGTC_1402 3909-7673 35.9 µM -0.146264218343335 0.438380455434512 no 1881 0.441856405829411 2635 5328014 SGTC_3098 9119039 49.47 µM -0.146594808094938 0.438246711032731 no 1882 0.441725925974455 2643 17161528 SGTC_833 3852-0053 558 µM -0.14683606471321 0.438149111967472 no 1883 0.441630708838238 2810 3123681 SGTC_1676 st018489 23.4 µM -0.14723656865835 0.437987098563079 no 1884 0.441472648754425 2737 3696235 SGTC_1084 voriconazole 435 nM -0.147515801692653 0.437874148284468 no 1885 0.441362454112382 2678 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2408 sulbentine 18.36 µM -0.147976663950324 0.43768773972429 no 1886 0.441180592469955 2786 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1831 st055328 12 µM -0.148065891135841 0.437651650903589 no 1887 0.441145383809757 2749 1103068 SGTC_755 1995-0008 37.3 µM -0.149609665622427 0.437027338359481 no 1888 0.440536290977773 2657 689533 SGTC_2473 5854593 8.94 µM -0.150843938326125 0.436528303081261 no 1889 0.440049412514224 2640 2872951 SGTC_2298 7976326 193.81 µM -0.151974118516269 0.436071442557268 no 1890 0.439603674473355 2720 2235818 SGTC_570 0987-0065 62.6 µM -0.152566673743991 0.435831943915932 no 1891 0.439370003881667 2655 3104428 SGTC_1135 dihydrocapsaicin 536.708 nM -0.152638988034858 0.435802717575438 no 1892 0.439341488620461 2652 107982 A Capsaicinoid. SGTC_369 0957-0393 4.5 µM -0.154347586155433 0.435112277707418 no 1893 0.438667839249671 2730 6997992 SGTC_2836 9010338 19.48 µM -0.15935017026598 0.433091891969811 no 1894 0.436696497769427 2705 2994051 SGTC_3054 9094397 49.47 µM -0.159454441845013 0.433049798381989 no 1895 0.436655424573105 2726 2598354 SGTC_515 4092-1064 102 µM -0.161068681575581 0.432398240133018 no 1896 0.436019653311758 2874 717353 SGTC_1132 3456-3614 2.5 µM -0.161572783239825 0.432194806322252 no 1897 0.435821145742907 2969 3125502 SGTC_687 k029-0044 34.9 µM -0.161980627271202 0.432030231116094 no 1898 0.435660554795252 2803 5829338 SGTC_930 2810-3379 265 µM -0.162738899306103 0.431724280868817 no 1899 0.43536200901061 2897 1015764 SGTC_2067 5224629 34.075 µM -0.163846179737216 0.431277585104004 no 1900 0.434926118357501 2848 2835000 SGTC_1540 guanosine 70.6 µM -0.164141255882994 0.431158561173244 no 1901 0.434809972367091 2679 6802 Guanosine is a purine nucleoside SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.164375531850129 0.431064066469523 no 1902 0.434717762160793 3041 5282309 SGTC_3313 9133968 57.047 µM -0.165337357189514 0.430676157715496 no 1903 0.434339228318708 2673 1494643 SGTC_2379 9035213 200 µM -0.16553994474892 0.430594461699241 no 1904 0.434259506072056 2752 646551 SGTC_1254 0550-0035 264 µM -0.166170258197419 0.430340298778029 no 1905 0.434011482267838 2838 15121435 SGTC_327 1273-0057 3.96 µM -0.167549763229427 0.429784138230653 no 1906 0.43346874774103 2758 3108138 SGTC_807 1315-0151 48 µM -0.169352886792797 0.429057402057074 no 1907 0.432759539521728 2813 4011080 SGTC_1192 1488-0095 21.4 µM -0.170240709445494 0.428699659606561 no 1908 0.432410418731479 2778 915875 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.171525966883941 0.428181877200105 no 1909 0.431905107185992 2783 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2091 4-phenylthiadiazole 200 µM -0.171799857496012 0.428071552811162 no 1910 0.431797438780263 2733 270010 SGTC_2073 5212005 126 µM -0.172455566028271 0.42780745327874 no 1911 0.431539695550863 2679 691789 SGTC_444 curcumin 90.4 µM -0.172796185798453 0.427670274709999 no 1912 0.431405817619166 2834 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2704 st078022 71.1 µM -0.174898289676312 0.426823883761373 no 1913 0.430579777100821 2854 54697681 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.176446684479141 0.426200653387173 no 1914 0.42997151552013 2728 6708514 SGTC_270 tamoxifen 5.46 µM -0.176768447727151 0.426071166447593 no 1915 0.429845136894435 2890 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2308 7584454 197.62 µM -0.177958375639984 0.425592374006847 no 1916 0.429377832652796 2847 893577 SGTC_392 N-ethylmaleimide 8.33 µM -0.178059173762663 0.425551820799005 no 1917 0.429338252110724 2769 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2436 5633522 8.09 µM -0.17851712238909 0.425367588343883 no 1918 0.429158437723833 2808 5724242 SGTC_2755 lomerizine 42.69 µM -0.179211858467222 0.425088127564295 no 1919 0.428885676377362 2759 3949 A calcium channel blocker. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.180054688006103 0.424749146051881 no 1920 0.428554817440623 2840 688662 SGTC_2401 5128683 200 µM -0.180204825863785 0.424688767243689 no 1921 0.428495884981681 2770 708373 SGTC_2924 9010168 62.78 µM -0.180933927562188 0.424395579927852 no 1922 0.428209718993213 2811 2993929 SGTC_29 0299-0004 12.984 µM -0.181190935857455 0.424292241383397 no 1923 0.428108854494043 2707 16871 A napthoquinone isolated from Swertia calycina. SGTC_1114 scopoletin 1.73284 µM -0.181469850237974 0.424180100673781 no 1924 0.427999398130562 2742 5280460 A coumarin with genotoxic properties. SGTC_2546 rhodinyl acetate 100 µM -0.182618629887995 0.423718285508902 no 1925 0.427548632812512 2738 6708682 SGTC_2125 5246583 200 µM -0.183684385537247 0.423289940060924 no 1926 0.427130529508813 2789 835267 SGTC_3204 9114183 49.47 µM -0.183919845483488 0.4231953168846 no 1927 0.427038167967258 2694 17027248 SGTC_2543 pimpinellin 60.67 µM -0.183938528152652 0.423187809158221 no 1928 0.427030839672828 2742 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1944 st076371 56.9 µM -0.184304901407426 0.423040585827649 no 1929 0.426887134513775 2742 24208455 SGTC_1296 1068-0102 11.9 µM -0.184357257565908 0.423019547920068 no 1930 0.426866599281384 2848 767053 SGTC_2022 5136654 200 µM -0.184660713278106 0.422897616766925 no 1931 0.426747581208265 2877 1713771 SGTC_1808 st050063 61.5 µM -0.185922509518385 0.422390695359665 no 1932 0.426252764956851 2841 4011993 SGTC_2429 5902844 64.44 µM -0.186180510195979 0.422287060455951 no 1933 0.426151603675003 2890 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2958 9077254 16.72 µM -0.186697491915462 0.422079413049491 no 1934 0.425948911343591 2914 16457351 SGTC_834 0312-0008 75.7 µM -0.187963383328349 0.421571055162711 no 1935 0.425452677694187 2719 6385573 YIL048W NEO1 SGTC_2374 9071832 200 µM -0.18905973838891 0.421130885417649 no 1936 0.425022998233858 2730 17381698 SGTC_2083 5306046 65.942 µM -0.190465101467546 0.420566797904658 no 1937 0.424472343791093 2781 539837 SGTC_3109 9122853 49.47 µM -0.191552033720759 0.420130634583506 no 1938 0.424046559080834 2799 1234709 SGTC_1419 3993-2473 62.6 µM -0.192008517861929 0.419947486196526 no 1939 0.423867766640697 2760 704026 SGTC_690 glyoxal 20.3 µM -0.192941163718244 0.419573348411894 no 1940 0.423502523342001 2754 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2262 9014885 67.46 µM -0.192956993706265 0.419566998721534 no 1941 0.423496324559448 2764 6457424 SGTC_2933 9026794 32.47 µM -0.193057909492835 0.419526520093143 no 1942 0.423456807917398 2800 17586027 SGTC_2254 7938975 95.19 µM -0.193502265895307 0.419348293123289 no 1943 0.423282815832092 2953 2969277 SGTC_1707 st032323 6.317 µM -0.193677187128418 0.419278138478781 no 1944 0.423214327818181 2750 3132057 YMR211W DML1 SGTC_3225 9130819 49.47 µM -0.193894149881847 0.41919112605116 no 1945 0.42312938224653 2833 4547121 SGTC_435 c-PAF 6.7 µM -0.194697813832192 0.418868852883293 no 1946 0.422814761735329 2909 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2275 7947463 200 µM -0.195124558781442 0.418697748188397 no 1947 0.422647718478728 2711 1225414 SGTC_539 4859-0462 2.54 µM -0.195605439318705 0.418504956095421 no 1948 0.422459501283062 2929 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_411 enrofloxacin 100 µM -0.196121432492169 0.418298108600996 no 1949 0.422257560651906 2903 71188 A bacterial gyrase inhibitor. SGTC_3023 9089636 49.47 µM -0.196224032882044 0.418256981613094 no 1950 0.422217409090517 2755 17249241 SGTC_3345 9148410 3.559 µM -0.197770884320645 0.417637040473461 no 1951 0.421612163575505 2881 4903596 SGTC_1797 st048695 56.8 µM -0.197782416951487 0.417632419236919 no 1952 0.421607651829827 2891 592262 YIL048W NEO1 SGTC_2811 7967822 32.47 µM -0.198635066776043 0.417290785770694 no 1953 0.421274110419677 2893 2232244 SGTC_2516 gossypol 71.55 µM -0.198759648963085 0.417240874316753 no 1954 0.421225380813205 2907 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_126 0417-1624 672.48 µM -0.19970657643101 0.41686154970961 no 1955 0.420855035068986 2793 41912 YDL195W SEC31 SGTC_2351 9026858 72.31 µM -0.201579091564321 0.416111677040428 no 1956 0.420122896095524 2748 1409300 SGTC_1837 st055472 66.5 µM -0.201762464721189 0.416038259278668 no 1957 0.420051213419613 2924 676091 SGTC_1892 st058411 7.36 µM -0.203559140727117 0.415319073101493 no 1958 0.419349012754679 2901 3934738 SGTC_1655 st012546 55.1 µM -0.203652576440639 0.415281679731038 no 1959 0.41931250197913 2872 720985 YLR208W SEC13 SGTC_967 1306-0166 352 µM -0.203746385058576 0.415244137894583 no 1960 0.419275846187008 2882 4437607 SGTC_252 miconazole 1.30953 nM -0.206140453764433 0.414286303888431 no 1961 0.418340599883953 2852 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2012 4023501 200 µM -0.206566240723403 0.414116005581703 no 1962 0.418174313794986 2851 3477460 SGTC_3244 9134489 49.47 µM -0.207936947924233 0.413567885559449 no 1963 0.417639099685856 2846 16584271 SGTC_2220 6782180 200 µM -0.207939703900479 0.413566783665658 no 1964 0.417638023725059 2782 833803 SGTC_2458 5808907 16.39 µM -0.20859817727993 0.413303532518376 no 1965 0.417380966797589 2844 2731747 SGTC_711 k292-0785 179 µM -0.209066383789703 0.413116371884563 no 1966 0.417198208325556 2751 4146315 SGTC_1859 st055998 20 µM -0.209759059565905 0.412839518243978 no 1967 0.416927863942788 2859 676301 SGTC_2720 fluspirilene 36.88 µM -0.210264018041768 0.412637720116128 no 1968 0.416730808478581 2871 3396 An atypical antipsychotic. SGTC_187 1488-2104 32.728 µM -0.210318644129752 0.412615891105519 no 1969 0.416709492396497 2836 2852859 SGTC_1223 0764-0573 147 µM -0.210895531407691 0.412385378962451 no 1970 0.416484395565548 2779 1609797 SGTC_598 3937-0236 20.2 µM -0.211617549952974 0.412096917974097 no 1971 0.416202708260715 2852 1379313 SGTC_2684 capsaicin 100 µM -0.211765376006213 0.412037864332285 no 1972 0.416145040914215 2867 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_712 r015-0009 80.6 µM -0.212439043048524 0.411768772652537 no 1973 0.415882264440377 2900 6813872 YLR060W FRS1 SGTC_2224 6650123 117.647 µM -0.2124442788483 0.411766681410545 no 1974 0.415880222265523 2775 2908370 SGTC_3207 9114163 49.47 µM -0.212833885337336 0.411611074884692 no 1975 0.415728266266565 3050 849233 SGTC_1832 st054113 55 µM -0.213575748488986 0.411314817586423 no 1976 0.415438956464809 2826 1251267 SGTC_1262 0737-0114 49.6 µM -0.214807155873171 0.410823176293376 no 1977 0.414958836775063 2889 765919 SGTC_199 4063-0024 41.6 µM -0.215454962729522 0.410564594582276 no 1978 0.414706310992032 2902 306215 SGTC_2077 5212015 200 µM -0.216749285473151 0.410048062992039 no 1979 0.414201868322234 2735 780900 SGTC_1972 st070201 17.4 µM -0.217556287099535 0.40972608789528 no 1980 0.413887423234764 2929 2829099 SGTC_890 0929-0006 47.2 µM -0.21759734873752 0.409709706871195 no 1981 0.413871425199252 2803 1378169 SGTC_425 3825-7017 13.1 µM -0.217808504629804 0.409625471373207 no 1982 0.413789158954926 3043 3397440 SGTC_1349 flufenamic acid 69 µM -0.219192262269373 0.409073558395656 no 1983 0.413250141374587 2771 3371 A non-steroidal anti-inflammatory. SGTC_19 0279-0214 38.434 µM -0.221589932227821 0.408117672824618 no 1984 0.412316560294584 2787 3566274 YBR002C RER2 SGTC_763 3453-1109 128 µM -0.222494424941075 0.407757217940238 no 1985 0.411964506384137 2933 1560353 SGTC_2446 5162541 200 µM -0.222935231180302 0.40758157784446 no 1986 0.411792957901568 2774 1549321 SGTC_2050 5263056 171 µM -0.223565659847211 0.407330414616005 no 1987 0.411547643396366 2953 763468 YGL055W OLE1 SGTC_549 1661-1316 519 µM -0.224805902763931 0.406836412239872 no 1988 0.411065136934263 2923 2857282 SGTC_1401 3807-4679 7.6 µM -0.225767189839635 0.406453622943008 no 1989 0.410691248478371 2784 3291456 SGTC_1400 3771-8998 51.5 µM -0.227208325953949 0.405879922915983 no 1990 0.410130876907992 2811 670767 SGTC_3022 9087993 49.47 µM -0.227441160378067 0.405787253087808 no 1991 0.410040358722962 2827 17173644 SGTC_802 4112-3352 742 µM -0.227621271654482 0.405715571084821 no 1992 0.409970340810574 2957 704594 SGTC_2490 carminic acid 95.39 µM -0.227795405725474 0.405646270939547 no 1993 0.409902649254446 2766 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_397 arbidol 50 µM -0.229363990177473 0.405022154850359 no 1994 0.409293010912565 2957 131410 A RNA synthesis inhibitor. SGTC_675 1309-0189 238 µM -0.229980539877857 0.404776905053252 no 1995 0.40905344568864 2856 4246530 SGTC_905 2-aminofluorene 215 µM -0.230012047756719 0.404764372921506 no 1996 0.409041203966605 2804 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1796 st049173 110.4 µM -0.230726374959732 0.404480278393457 no 1997 0.408763691020485 2826 94134 SGTC_2750 bromebric acid 70.15 µM -0.233497894175387 0.40337849758603 no 1998 0.40768740228676 2960 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.233610101476677 0.403333907143072 no 1999 0.407643842439301 2908 6708739 YPR165W RHO1 SGTC_2879 9041815 71.43 µM -0.233705874090616 0.403295848730789 no 2000 0.407606663583178 2908 4942971 SGTC_2563 tomatine 8.54 µM -0.235046786087098 0.402763089389023 no 2001 0.40708621009729 2872 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3167 9103034 49.47 µM -0.237220986251213 0.401899639339638 no 2002 0.406242678121301 2797 5127859 SGTC_1456 k015-0012 13 µM -0.238244179167305 0.401493459413506 no 2003 0.405845856698784 2882 2989616 SGTC_13 0199-0087 65 µM -0.238861951575316 0.401248271959179 no 2004 0.405606314933468 2813 4589825 SGTC_449 xestospongin c 11.1929 µM -0.239522070228721 0.400986320693008 no 2005 0.405350392440348 2954 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2889 9059656 51.95 µM -0.242550329336474 0.399785205371142 no 2006 0.404176881822131 2931 3949838 SGTC_1431 4049-0260 9.09 µM -0.244505846404398 0.399010080521423 no 2007 0.403419537292854 2809 3854841 SGTC_1509 1326-1131 80 µM -0.244571111826081 0.398984217561542 no 2008 0.4033942671317 2888 768313 SGTC_1168 k815-0004 80.5 µM -0.245472792633705 0.398626950747299 no 2009 0.403045186077567 2828 642433 SGTC_657 3534-0529 86.7 µM -0.247723358760492 0.39773559550931 no 2010 0.402174228701767 3004 1049549 SGTC_2113 5491891 107.031 µM -0.247900259188509 0.397665555198675 no 2011 0.402105789681073 2860 789979 SGTC_957 1187-1561 14.1 µM -0.248186964178641 0.397552046897028 no 2012 0.40199487598067 2812 1538454 SGTC_1802 st050112 57.9 µM -0.250477699477349 0.396645442718433 no 2013 0.40110897419591 2831 4662563 SGTC_3286 9117135 37.221 µM -0.250589501898818 0.396601208934068 no 2014 0.401065749536884 2882 3438150 SGTC_234 nsc-17383 10.7 µM -0.251466999459906 0.396254079895764 no 2015 0.4007265366072 2999 408974 SGTC_637 1181-0519 7.26 µM -0.252383356178709 0.395891666352373 no 2016 0.400372381842401 2856 6252091 YGR060W ERG25 SGTC_1875 nocodazole 6 µM -0.252444340533173 0.395867550598713 no 2017 0.400348815431336 2891 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2352 9027995 87.8 µM -0.253119210550006 0.395600705517994 no 2018 0.400088047139916 2910 2997347 SGTC_2456 5770359 74.46 µM -0.253396264067011 0.395491172111765 no 2019 0.399981007159571 3002 3118787 SGTC_2269 7935389 174.42 µM -0.253895019810962 0.395294009303159 no 2020 0.399788331185706 2825 97605 SGTC_2219 9098279 200 µM -0.255250493353217 0.394758313467016 no 2021 0.39926481711874 2910 902349 SGTC_2430 5571206 200 µM -0.255706438321028 0.394578164404812 no 2022 0.399088761677399 3023 1731771 SGTC_2650 prasterone 100 µM -0.256076508634166 0.394431961970962 no 2023 0.398945880370852 2863 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1329 1447-1697 50.6 µM -0.258399090194905 0.393514727793293 no 2024 0.398049459341086 2970 2840515 SGTC_1644 st010134 20.9 µM -0.258632258996702 0.393422677282532 no 2025 0.397959495398676 2918 3818134 SGTC_2349 9023730 187.07 µM -0.25863925513437 0.39341991543539 no 2026 0.397956796149978 3006 4126287 SGTC_3281 9140613 49.47 µM -0.258662010254481 0.393410932492665 no 2027 0.397948016807012 2896 16013766 SGTC_1219 1469-0211 33.1 µM -0.258710321458842 0.393391861070536 no 2028 0.39792937762903 2971 6822282 SGTC_2768 sulfasalazine 50.2 µM -0.259633483355572 0.393027481133924 no 2029 0.39757325290495 2976 5384001 An antioxidant and salicylic acid derivative. SGTC_1614 st002383 48.6 µM -0.26190056681303 0.392133042041265 no 2030 0.396699051306934 2895 1947235 SGTC_2046 4110841 106 µM -0.262197121753354 0.392016083381204 no 2031 0.396584736150703 3032 44119630 YMR134W ERG29 SGTC_762 1165-0429 115 µM -0.266301854257416 0.39039821949004 no 2032 0.395003372578608 3024 5967793 SGTC_746 1095-0025 46.6 µM -0.266809535806137 0.390198250031935 no 2033 0.394807905911149 3053 6749286 SGTC_2218 6965428 192.983 µM -0.267091699708806 0.390087121730285 no 2034 0.394699279099138 2923 675684 SGTC_2802 7925815 54.55 µM -0.267720713675161 0.389839421271795 no 2035 0.39445715222252 2865 1262923 SGTC_2489 cantharidin 73.42 µM -0.268141626331618 0.389673694350152 no 2036 0.394295152722436 2849 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.268174315748814 0.38966082430871 no 2037 0.39428257209016 3000 5357218 A potent inhibitor of glutathione S-transferases. SGTC_877 0771-0151 33.1 µM -0.270680811402365 0.388674361582232 no 2038 0.393318268164358 2973 6166523 SGTC_1852 st056254 31.4 µM -0.270714524187622 0.388661098369553 no 2039 0.393305302560383 2879 442583 SGTC_2657 nystatin 74.44 µM -0.270931585856307 0.388575705535629 no 2040 0.393221825622385 2942 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2900 5328528 85.29 µM -0.271459427910882 0.388368073065281 no 2041 0.393018850168592 2883 795359 SGTC_951 1171-0579 82.7 µM -0.272519018601572 0.387951367765246 no 2042 0.392611484868397 2834 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3261 9137475 49.47 µM -0.272777705802729 0.387849653404593 no 2043 0.392512049038168 2916 17027690 SGTC_1384 3089-0840 101 µM -0.273126332206323 0.387712587626261 no 2044 0.392378052906445 3012 1069836 SGTC_350 k064-0020 19.8 µM -0.273143187339192 0.387705961225295 no 2045 0.392371574883259 3090 2790705 SGTC_386 1509-0011 3.07 µM -0.273376735631004 0.387614147776757 no 2046 0.392281817091996 2883 3107280 SGTC_1572 epiandrosterone 68.9 µM -0.273401495445102 0.387604414466895 no 2047 0.392272301681878 2861 441302 A steroid. SGTC_2987 9018338 71.43 µM -0.27353084828724 0.38755356582764 no 2048 0.392222591316343 2901 5055682 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.274228096521751 0.387279510585634 no 2049 0.391954668762705 2879 229346 A bile salt which induces apoptosis. SGTC_253 dyclonine 31.25 µM -0.27526827261847 0.386870771088954 no 2050 0.391555069003484 2904 3180 An oral anasthetic. SGTC_3015 9080845 49.47 µM -0.275628077766967 0.386729414036985 no 2051 0.391416870892304 3026 5296973 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.276425316015434 0.386416255710595 no 2052 0.391110707280142 2900 97141 SGTC_129 0088-0017 176.636 µM -0.276879618308364 0.386237837049446 no 2053 0.390936271616316 3012 182446 SGTC_3047 9092122 49.47 µM -0.277238462676724 0.386096924689886 no 2054 0.390798503853958 2961 17173831 SGTC_2353 9059630 146.67 µM -0.278171447205508 0.385730627164335 no 2055 0.390440376009238 3008 4779114 SGTC_2517 totarol 10 µM -0.279217558772759 0.385320036180499 no 2056 0.390038934672877 2977 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2963 9082507 9 µM -0.28120399852922 0.384540727445223 no 2057 0.389276968986726 3070 16459611 SGTC_1220 1838-0075 193 µM -0.28370815185312 0.383558977098421 no 2058 0.388317023526017 2924 5529645 SGTC_2870 9038528 12.99 µM -0.28378123942469 0.383530334392896 no 2059 0.388289016251707 3024 6463316 SGTC_1347 1493-0251 600 nM -0.285906537917021 0.382697717986355 no 2060 0.387474853072411 3039 3986378 SGTC_571 k831-0106 44.2 µM -0.286545563562206 0.382447476231431 no 2061 0.387230150529586 3002 4783639 SGTC_1591 genipin 88.4 µM -0.286830587008 0.382335877178431 no 2062 0.387121020742593 3048 442424 A DNA cross-linking agent. SGTC_328 k915-0120 63.5 µM -0.287023662582674 0.382260285260486 no 2063 0.387047101027817 3021 6624543 SGTC_3284 9108171 64.8615 µM -0.287462103066518 0.382088646051826 no 2064 0.386879257645163 3016 8687505 SGTC_2 0422-0095 29 µM -0.287557527235738 0.382051292787531 no 2065 0.386842730254363 2952 6790840 SGTC_722 3534-0461 190 µM -0.289333137273498 0.381356440667716 no 2066 0.386163228158763 2961 658262 SGTC_599 1935-0052 86.5 µM -0.290059255441873 0.381072397759269 no 2067 0.385885452925975 2913 9557311 SGTC_2513 baicalein 25.65 µM -0.290374089717245 0.380949260788118 no 2068 0.385765031798489 2965 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2847 9005661 71.43 µM -0.291580502199287 0.38047752431859 no 2069 0.385303692461271 2995 2991449 SGTC_398 bronopol 33.3 µM -0.291731896087155 0.380418338179118 no 2070 0.385245809980229 2890 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1818 st052136 56.3 µM -0.2937891386246 0.37961435489314 no 2071 0.384459517577938 3008 674169 SGTC_32 0928-0142 34.1 µM -0.294354857638476 0.379393359400204 no 2072 0.38424337899328 3009 2244242 SGTC_2094 5332512 191.667 µM -0.294610132451716 0.379293650382325 no 2073 0.384145860487954 3077 755774 SGTC_2295 7971645 200 µM -0.295090098660367 0.379106199815029 no 2074 0.383962526627366 2981 2978226 YKL099C UTP11 SGTC_1743 st037606 46.3785 µM -0.298085164197032 0.377937122155276 no 2075 0.382819082207868 2942 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2236 dapsone 200 µM -0.299104609451776 0.377539451675455 no 2076 0.382430114679864 2961 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2250 alverine citrate 130 µM -0.299596167812344 0.377347748398475 no 2077 0.382242603812634 2880 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3271 9137798 49.47 µM -0.300288537081537 0.377077781965458 no 2078 0.381978538048019 3045 6498326 SGTC_379 3970-0972 5.9 µM -0.300510345449302 0.376991307848469 no 2079 0.381893953182706 2980 2898042 YBL034C STU1 SGTC_2905 7799065 20.05 µM -0.301688331154068 0.376532162320997 no 2080 0.381444832228412 3114 1296806 SGTC_2960 9079389 5.97 µM -0.301981656051407 0.376417859697642 no 2081 0.381333023442772 3106 16457355 SGTC_1043 0916-0009 19.3 µM -0.302178014405218 0.376341348977696 no 2082 0.381258181633408 3129 3101130 SGTC_1615 st002656 86.5 µM -0.302270013828268 0.376305503220316 no 2083 0.381223117663849 2920 1584458 SGTC_2691 st077356 60.2 µM -0.302838576318334 0.376083997761467 no 2084 0.38100644166781 3106 2839272 SGTC_1679 SEC14.276 6.7 µM -0.303956827277287 0.375648459091109 no 2085 0.38058039135835 3069 1005053 YMR079W SEC14 SGTC_2791 5663188 71.43 µM -0.304360337404343 0.375491338005901 no 2086 0.380426690716818 3115 54690634 SGTC_950 1165-0508 94.1 µM -0.304853100014794 0.375299491284993 no 2087 0.380239018602242 3022 6148369 SGTC_3105 9121040 49.47 µM -0.305179051113607 0.375172606048288 no 2088 0.380114893316293 2928 41448907 SGTC_1654 st012436 41.8 µM -0.305295459814239 0.375127294101361 no 2089 0.380070566764737 3016 4323132 SGTC_96 0929-0093 37.281 µM -0.305451747125251 0.375066462163173 no 2090 0.380011057560264 2941 6991579 SGTC_3332 9141069 11.198 µM -0.308310738558793 0.373954202558698 no 2091 0.378922947799161 2917 17332883 SGTC_62 0180-0423 3.232 µM -0.308647618820113 0.373823211833168 no 2092 0.378794796790947 2983 30102 YGL099W LSG1 SGTC_1191 1487-1166 10.6 µM -0.309524277220321 0.373482404986966 no 2093 0.378461373847929 3060 3955771 SGTC_1709 st033179 39.1045 µM -0.310179459926697 0.373227762886301 no 2094 0.378212244682615 2950 573381 SGTC_2760 etidronate 98.04 µM -0.311973353581324 0.372530835084363 no 2095 0.377530387079627 2979 3305 A chelator and antioxidant. SGTC_2741 miltefosine 3.04 µM -0.312116736708279 0.37247514870438 no 2096 0.377475903701429 2965 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2666 tannic acid 100 µM -0.312882129953588 0.372177934450543 no 2097 0.377185107336668 3031 16134267 A thiamine antagonist. SGTC_888 0916-0002 6.97 µM -0.316590494408681 0.370738999047667 no 2098 0.375777174705811 3138 2802138 YIL048W NEO1 SGTC_2766 oltipraz 83.91 µM -0.318759315396819 0.369898279510192 no 2099 0.374954515856854 3118 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_330 1488-0319 80.1 µM -0.318958838687592 0.369820967659881 no 2100 0.374878862872796 3037 6846614 SGTC_1527 coumarin 137 µM -0.318995952618922 0.369806587228842 no 2101 0.374864790963186 3145 323 A hepatotoxic, DNA x-linker. SGTC_2983 9022671 12.99 µM -0.319893768234382 0.369458768644848 no 2102 0.374524431043017 3162 6405161 SGTC_1656 st012921 11 µM -0.320002547503975 0.369416634221595 no 2103 0.374483199695301 3078 6732821 SGTC_601 0986-0029 62.9 µM -0.320016856919671 0.369411091747524 no 2104 0.374477776006781 2991 24747981 SGTC_3080 9117754 49.47 µM -0.320252221353828 0.36931993180352 no 2105 0.374388569543103 3189 9550191 SGTC_1496 4469-0713 57.4 µM -0.321461039176462 0.368851855594436 no 2106 0.373930516460395 3080 746691 SGTC_2202 7226349 200 µM -0.322739101945641 0.368357177974481 no 2107 0.37344641818862 2960 844334 SGTC_1658 st012944 20 µM -0.322849932238236 0.368314291079415 no 2108 0.373404447837133 3049 24207260 SGTC_2105 5350118 200 µM -0.3236165794421 0.368017674197756 no 2109 0.373114167161281 2989 2133313 SGTC_791 1348-1292 225 µM -0.323845558809398 0.367929097008592 no 2110 0.373027481155364 3018 5437054 SGTC_2318 6029776 164 µM -0.327485634752544 0.36652193496353 no 2111 0.371650303155619 3176 818325 SGTC_2991 9074669 71.4286 µM -0.327541526114314 0.366500342689747 no 2112 0.371629170093649 3162 17333109 SGTC_2808 7946468 45.46 µM -0.328092777263553 0.366287402806833 no 2113 0.371420757461165 3057 2970879 SGTC_1834 st055981 52.8 µM -0.329901871512868 0.365588866926428 no 2114 0.370737054668375 3130 471719 YDL150W RPC53 SGTC_1311 1190-0148 100 µM -0.330270835241263 0.365446455559421 no 2115 0.370597663895618 3117 1961333 SGTC_2281 7943571 200 µM -0.330579840364153 0.365327201082063 no 2116 0.370480937947089 3202 1244024 SGTC_3096 9117468 49.47 µM -0.331333975757785 0.36503621197495 no 2117 0.370196115177074 3106 41316311 SGTC_1706 st031321 9.9705 µM -0.332456085971596 0.364603380742478 no 2118 0.369772446988226 3093 6103185 SGTC_650 1328-0195 38 µM -0.332558642648673 0.364563830184105 no 2119 0.36973373317429 3097 2780821 SGTC_2770 toltrazuril 17.5 µM -0.332601738727256 0.364547210789791 no 2120 0.369717465358184 3036 68591 Kills coccidiodes. SGTC_2415 st077333 57.7 µM -0.333186354794848 0.364321787020425 no 2121 0.36949680877559 3237 2766255 SGTC_1836 st055642 81 µM -0.333196399900975 0.364317914109272 no 2122 0.369493017741673 3008 8571 SGTC_54 0159-0055 9 µM -0.333815789581084 0.364079133931923 no 2123 0.369259283932251 3229 3319099 SGTC_729 4092-0585 94.1 µM -0.33405433600211 0.363987186252457 no 2124 0.369169278585184 2972 2169061 SGTC_1833 st055984 71 µM -0.334293107521538 0.363895159649925 no 2125 0.369079195488977 3021 676288 SGTC_2176 5809774 33.9695 µM -0.334301589748954 0.363891890599638 no 2126 0.369075995468559 3110 2870539 SGTC_1504 k297-0033 30 µM -0.334545543333149 0.363797875133308 no 2127 0.368983964983439 2945 4388117 SGTC_3053 9095903 49.47 µM -0.334732055789152 0.36372600200874 no 2128 0.368913608993308 3063 17174018 SGTC_2571 chrysanthemic acid 100 µM -0.335848679514379 0.363295808132944 no 2129 0.368492489558848 3031 2743 An insecticide. SGTC_493 zm226600 134 µM -0.336354309588844 0.363101064208197 no 2130 0.368301849970435 3168 5240098 A potassium channel opener. YCR052W RSC6 SGTC_865 0488-0499 301 µM -0.337265126403046 0.362750351528395 no 2131 0.367958523144765 3163 9634651 SGTC_348 k064-0012 10.7 µM -0.33905065790006 0.362063161632288 no 2132 0.36728578418662 2961 5066323 SGTC_643 k048-0106 28.4 µM -0.339285010427019 0.361973000318865 no 2133 0.367197516811463 3086 6763920 SGTC_1237 0330-0133 46.1 µM -0.339335396286273 0.361953616611351 no 2134 0.367178540217464 2978 X1237 YHR072W ERG7 SGTC_814 3342-0569 96 µM -0.339664517992822 0.361827010456543 no 2135 0.367054592609062 3020 4346283 SGTC_1445 4239-0156 97.7 µM -0.341439651822491 0.361144415077779 no 2136 0.366386314387932 3186 4008346 SGTC_3115 9123671 49.47 µM -0.341600113277036 0.361082734294674 no 2137 0.366325925971484 3097 3286988 SGTC_3150 9097574 49.47 µM -0.342045243381794 0.360911646858899 no 2138 0.366158422060949 3174 17217476 SGTC_3297 9117502 71.43 µM -0.343070244870863 0.360517789531353 no 2139 0.365772807675598 3096 7453720 SGTC_583 1488-1091 88.9 µM -0.344278193923234 0.360053824430453 no 2140 0.365318540902662 3102 4303273 SGTC_813 k007-0158 173 µM -0.345219075589062 0.359692580848587 no 2141 0.36496483952127 3061 6523916 SGTC_2822 7994718 71.43 µM -0.34535217104696 0.359641490080269 no 2142 0.364914814816207 3001 1018011 SGTC_148 3253-0744 288.01 µM -0.345563979007498 0.359560189462269 no 2143 0.364835210298849 3010 6893655 SGTC_2736 butenafine 14.65 µM -0.346491437912387 0.359204267434727 no 2144 0.364486708868728 3024 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2187 6125751 200 µM -0.34751436656222 0.358811849566048 no 2145 0.36410246365013 3047 874498 SGTC_757 1066-0008 322 µM -0.348353297759293 0.358490128324541 no 2146 0.363787435763948 3161 6842497 SGTC_2888 9058547 12.99 µM -0.348527347475875 0.358423394668205 no 2147 0.363722089705591 3013 16476514 SGTC_1009 4106-0057 9.87 µM -0.349347833155472 0.358108864600892 no 2148 0.363414096051763 3182 2928005 SGTC_2279 7948423 32.93 µM -0.351214209604028 0.357393755159098 no 2149 0.362713825302814 3207 1247112 SGTC_1955 wogonin 32.4 µM -0.351803257525093 0.357168162927962 no 2150 0.36249290769877 3230 5281703 A flavanone. SGTC_2471 5466956 24.79 µM -0.352498397387446 0.356902004066749 no 2151 0.362232260070304 3025 724419 SGTC_233 rapamycin 362 pM -0.352679136280663 0.356832813196469 no 2152 0.362164501194647 3055 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_483 fpl-64176 144 µM -0.353272207723034 0.356605805344109 no 2153 0.361942189503938 3056 3423 SGTC_1494 4358-1428 177 µM -0.353298896732076 0.356595590880319 no 2154 0.361932186274744 3166 1564571 SGTC_3030 9087619 49.47 µM -0.353402336070575 0.356556003369269 no 2155 0.361893417370946 3072 25236973 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.354807149529607 0.356018517091676 no 2156 0.361367035934636 3212 94937 An inhibitor of serotonin biosynthesis. SGTC_1744 st037937 38.9 µM -0.355631159959998 0.355703380985974 no 2157 0.361058402490994 3224 1016152 SGTC_2172 5754775 163.918 µM -0.356963438613061 0.355194070471192 no 2158 0.360559588357845 3023 2263357 SGTC_694 1315-0438 43.2 µM -0.357163240197897 0.355117711541583 no 2159 0.360484801726067 3061 6793154 SGTC_818 4072-2707 53.5 µM -0.357476287046221 0.35499808493953 no 2160 0.360367637614963 2967 882871 SGTC_1283 0922-0125 16.4 µM -0.358500232651261 0.354606897917041 no 2161 0.359984496903056 3126 3360884 SGTC_1988 st071872 53.4 µM -0.359579170834041 0.354194867451401 no 2162 0.359580931185501 3157 16414116 SGTC_2928 9011484 9.79 µM -0.359614670307285 0.354181313626802 no 2163 0.359567655630792 3155 2994751 SGTC_2619 obliquin 87.91 µM -0.361645068788018 0.353406408206782 no 2164 0.358808640498258 3003 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1822 st052468 42 µM -0.361729470379708 0.353374209304288 no 2165 0.35877710105636 3104 2873678 SGTC_2606 farnesol 9.78 µM -0.363069388478887 0.352863176096833 no 2166 0.358276525524764 3206 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1888 azatryptophan 97.5 µM -0.363473611876419 0.352709060833698 no 2167 0.35812556082112 3145 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_579 4491-1009 110 µM -0.364490292975244 0.352321545245502 no 2168 0.357745960552268 3177 1271041 SGTC_636 0kpi-0074 126 µM -0.365047337261037 0.352109288622535 no 2169 0.357538035423757 3103 616434 SGTC_16 erodoxin 22.806 µM -0.365616320929367 0.351892530164809 no 2170 0.357325697387861 3174 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3146 9095609 49.47 µM -0.365725921258535 0.351850782649874 no 2171 0.357284800901152 3089 17173999 SGTC_1348 1493-0373 93.8 µM -0.366024885051779 0.3517369143786 no 2172 0.357173253287113 3098 3010129 SGTC_41 0478-0632 82.643 µM -0.366434211132701 0.351581033280599 no 2173 0.3570205477425 3134 3750424 SGTC_3339 9145883 14.936 µM -0.367352249066429 0.351231513398385 no 2174 0.356678142543834 3180 2030670 SGTC_367 0335-0881 7.1 µM -0.367947202547281 0.351005066961888 no 2175 0.356456301409932 3211 23828853 SGTC_2080 5212524 12.4 µM -0.368090153340706 0.350950666053536 no 2176 0.356403006380973 3163 260183 SGTC_655 k060-0012 42 µM -0.370699428432011 0.349958226266807 no 2177 0.355430708047313 3050 5994525 SGTC_1946 st076057 65.1 µM -0.370703083615145 0.349956836731845 no 2178 0.35542934666859 3021 953009 SGTC_1345 1488-0192 31.4 µM -0.371221784184827 0.349759670666557 no 2179 0.355236174535427 3204 658348 SGTC_2062 5245942 200 µM -0.371466257113967 0.34966675678891 no 2180 0.355145141919659 3074 1376160 SGTC_1139 k015-0024 46.9 µM -0.37165501496808 0.349595024027423 no 2181 0.355074861178375 3185 2766652 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.371811313782437 0.349535630586589 no 2182 0.35501666973372 3092 688788 SGTC_1924 st058459 75.1 µM -0.372006093471669 0.349461619595211 no 2183 0.354944156248719 3108 688683 SGTC_2103 5378138 10 µM -0.372123774650577 0.349416906716642 no 2184 0.354900347900279 3109 244142 SGTC_42 0133-0086 60.653 µM -0.373625809321468 0.348846393453939 no 2185 0.354341364657359 2987 162923 Model of phenazepam hydroxylation. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.373858976247154 0.348757860965107 no 2186 0.354254619517457 3123 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_701 4424-0219 185 µM -0.373957251503152 0.34872054873543 no 2187 0.354218060418384 3229 2911779 SGTC_825 1988-2224 89.6 µM -0.374028594023429 0.348693462991474 no 2188 0.354191521331568 3057 1180859 SGTC_1742 st038235 28.8875 µM -0.374267341449309 0.348602826279705 no 2189 0.354102713546884 3170 564103 YBR002C RER2 SGTC_921 1561-0023 372 µM -0.375712902628953 0.348054226400502 no 2190 0.353565172307805 3028 24050882 SGTC_255 tunicamycin 200.472 nM -0.375874614874736 0.34799287529735 no 2191 0.353505056701116 3129 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2337 9009472 200 µM -0.376407908273119 0.347790580306129 no 2192 0.353306833817779 3265 5742383 SGTC_191 3914-0123 66.505 µM -0.37762736529426 0.347328164707614 no 2193 0.352853716424403 3029 3144412 SGTC_1308 1187-1617 41.4 µM -0.377811293745431 0.34725843911456 no 2194 0.352785391655513 3048 2882570 SGTC_408 cantharidin 100 µM -0.377826199374601 0.347252788753323 no 2195 0.352779854799116 3088 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_605 1315-0399 119 µM -0.38019188874129 0.34635644452678 no 2196 0.351901489922085 3217 24020461 SGTC_903 1134-0042 114 µM -0.380958321028356 0.346066232501753 no 2197 0.351617087818458 3083 701009 SGTC_1454 4239-0054 42.6 µM -0.381124963366712 0.346003144806856 no 2198 0.351555262378566 3254 1340767 SGTC_3212 9128307 49.47 µM -0.381872517002386 0.345720187499476 no 2199 0.351277963236531 2985 27243542 SGTC_1982 st072467 71.9 µM -0.38210982905477 0.34563038027654 no 2200 0.351189950741934 3021 3163533 SGTC_467 ro 31-8220 72.8 µM -0.383621786878729 0.345058406457824 no 2201 0.350629394861961 3096 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2154 5570129 200 µM -0.38545139877331 0.344366737255113 no 2202 0.349951504005568 3142 673366 SGTC_2065 5221596 34.26 µM -0.386019753773407 0.344151981266593 no 2203 0.349741019569684 3202 788581 SGTC_2819 7996655 46.38 µM -0.386484885925096 0.343976265972458 no 2204 0.349568797009622 3112 6456960 SGTC_983 1491-0821 12.2 µM -0.386603678033243 0.343931394684272 no 2205 0.349524817308017 3186 46495113 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.3869841359892 0.34378769927131 no 2206 0.349383976198405 3099 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2969 9091408 28.7 µM -0.387022435959098 0.343773234980505 no 2207 0.349369799143509 3043 4286311 SGTC_1502 4534-4282 27.7 µM -0.390517884546516 0.342454115969955 no 2208 0.348076816553959 3136 3278949 SGTC_3356 9151811 4.48 µM -0.390519805475699 0.342453391572335 no 2209 0.348076106477055 3068 1859254 YPR165W RHO1 SGTC_2035 5154463 94.595 µM -0.390635583971823 0.342409731653983 no 2210 0.348033309612236 3237 2769623 SGTC_1207 2099-0101 141 µM -0.391677188586266 0.342017038680994 no 2211 0.34764837346437 3189 5837381 SGTC_3237 9133362 49.47 µM -0.392204109747302 0.34181845037821 no 2212 0.34745370388461 3184 43845137 SGTC_530 4358-1714 28 µM -0.39337740047255 0.341376412828844 no 2213 0.347020379417008 3156 1564641 SGTC_2909 7941780 10.49 µM -0.39434911593151 0.341010483451898 no 2214 0.346661652893805 3250 1243215 SGTC_1008 4106-0037 6 µM -0.394663023245896 0.340892303919829 no 2215 0.346545797627353 3023 2905394 SGTC_1303 1160-0052 261 µM -0.395219804507325 0.340682725839864 no 2216 0.346340339028109 3157 3562476 SGTC_245 methotrexate 289.6 µM -0.395368733148979 0.340626675930535 no 2217 0.346285390331407 3170 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_73 0327-0325 16.231 µM -0.395606954024392 0.34053702783721 no 2218 0.346197503108136 3195 53298 SGTC_2927 9011802 47.9 µM -0.396561400545665 0.340177937658107 no 2219 0.345845460677244 3188 43912568 SGTC_1350 1495-0454 146 µM -0.397368670110706 0.339874332765698 no 2220 0.345547807649924 3253 1069057 SGTC_1231 0242-0792 125 µM -0.397685236358401 0.339755304135191 no 2221 0.345431110728685 3088 3707635 SGTC_969 1313-0238 134 µM -0.397973418748923 0.339646961701818 no 2222 0.345324889821343 3095 5212874 SGTC_3157 9099274 49.47 µM -0.398133844847963 0.339586655102787 no 2223 0.345265763776796 3255 17217662 SGTC_2371 9071574 200 µM -0.398299143740259 0.339524521042858 no 2224 0.345204845783877 3215 45596039 SGTC_2016 5121758 140 µM -0.399022917095539 0.339252513870693 no 2225 0.344938159116718 3101 2795203 SGTC_2785 7756463 72.73 µM -0.402674061807711 0.337881626713532 no 2226 0.343594008928499 3081 2201551 SGTC_2523 spermine 47.74 µM -0.40430642914022 0.337269418976126 no 2227 0.342993699176017 3201 1103 A DNA binding polyamine. SGTC_1279 0874-0590 65.2 µM -0.404749488464286 0.337103326967648 no 2228 0.342830830582541 3164 3523074 SGTC_1141 3253-0389 52.6 µM -0.407980535446273 0.335893048952211 no 2229 0.341643982563077 3203 5402031 SGTC_831 k061-1017 217 µM -0.408161303746549 0.335825387281283 no 2230 0.341577627728014 3193 1240153 SGTC_1440 4100-1550 40 µM -0.408220791092507 0.335803122299625 no 2231 0.341555792707684 3160 742806 SGTC_2788 5282734 71.43 µM -0.408996516238621 0.335512835920754 no 2232 0.341271108878187 3270 743706 SGTC_953 1188-0045 9.7 µM -0.410482600650505 0.334956998173933 no 2233 0.340725982221214 3217 6144426 SGTC_1404 3909-7820 48.3 µM -0.410736736107551 0.334861980444794 no 2234 0.340632793310114 3231 23741373 SGTC_2093 5331342 194.4 µM -0.410987758103824 0.334768137172707 no 2235 0.340540755622475 3257 33839 SGTC_3341 9147222 25.867 µM -0.411296888900999 0.334652584404824 no 2236 0.340427425280126 3251 1939759 SGTC_1368 1852-0141 284 µM -0.411456743334422 0.334592837126519 no 2237 0.340368826748804 3224 2838987 SGTC_2346 9031566 143.75 µM -0.412843953578109 0.334074528703234 no 2238 0.33986047306372 3174 4771086 SGTC_3144 9087057 49.47 µM -0.413393718150269 0.333869205618917 no 2239 0.339659088162966 3245 17249618 SGTC_35 0133-0054 64.071 µM -0.414561722054938 0.333433150983701 no 2240 0.339231387250034 3157 99677 SGTC_1673 st016611 27.3 µM -0.416155633344985 0.332838454046064 no 2241 0.338648061272041 3283 5226799 SGTC_997 3996-0078 137 µM -0.416323205901218 0.332775956207552 no 2242 0.338586756954856 3172 735687 SGTC_1876 myriocin 605 nM -0.416718400665644 0.332628582822669 no 2243 0.338442196847416 3291 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3147 9097027 49.47 µM -0.417106887844616 0.332483735992406 no 2244 0.338300113540637 3135 25236841 SGTC_1346 1488-2224 62.4 µM -0.417225858464622 0.332439382986304 no 2245 0.33825660644048 3243 3722427 SGTC_128 0906-2981 13.371 µM -0.417453655090291 0.332354465498051 no 2246 0.338173308113314 3293 6740226 SGTC_2460 5552655 174.22 µM -0.417591348853625 0.332303140514441 no 2247 0.338122961514836 3257 5401989 SGTC_3311 9131146 2.8755 µM -0.417889892922177 0.332191869810021 no 2248 0.338013811261298 3164 4900406 YPR165W RHO1 SGTC_372 0155-0182 15.9 µM -0.41920250406657 0.331702820600111 no 2249 0.337534071103326 3107 771486 SGTC_278 4092-0821 23.9 µM -0.42042109553986 0.331249057577985 no 2250 0.337088929971145 3220 877900 SGTC_2479 5617353 43.85 µM -0.420671330925678 0.331155908854302 no 2251 0.336997549305171 3298 2731746 SGTC_3266 9136860 49.47 µM -0.422191563489404 0.330590235497659 no 2252 0.336442599449322 3231 4871271 YPR165W RHO1 SGTC_2381 9035592 200 µM -0.422763266158338 0.330377606882909 no 2253 0.336233995615907 3187 4749657 SGTC_1923 st058458 19.1 µM -0.422797916354259 0.330364721483094 no 2254 0.336221354013764 3345 3534982 SGTC_2192 5915882 198.485 µM -0.423203087739134 0.330214064962264 no 2255 0.336073547083197 3176 2876149 SGTC_941 3237-0776 460 µM -0.424402304654979 0.329768316628307 no 2256 0.335636220123173 3300 760008 SGTC_231 b-estradiol 524 µM -0.425535341767332 0.329347389295111 no 2257 0.33522323185387 3138 450 A steroid. SGTC_455 paf C-16 10 µM -0.426131745085866 0.329125910143543 no 2258 0.335005924767341 3148 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_159 3970-0959 50 µM -0.426248350228337 0.329082614895009 no 2259 0.334963444661672 3320 6615653 SGTC_1976 st070609 63.5 µM -0.427039883262234 0.32878878094014 no 2260 0.334675139226045 3125 682556 SGTC_592 k241-0073 46.5 µM -0.428180285087361 0.328365625497829 no 2261 0.33425993430337 3281 4230158 SGTC_2674 ligustilide 100 µM -0.429856821297144 0.327743932710261 no 2262 0.333649898239904 3240 5319022 A signalling regulator. SGTC_990 3985-0011 41.3 µM -0.429897677319881 0.327728788437963 no 2263 0.333635037564523 3182 5399565 YGL099W LSG1 SGTC_728 3030-5151 22.5 µM -0.430764117122172 0.327407688341075 no 2264 0.333319946485986 3159 3125388 SGTC_1186 1319-0216 26 µM -0.432523173976298 0.326756179770344 no 2265 0.332680606540121 3317 4565136 SGTC_595 3909-8003 73.7 µM -0.435675284153336 0.325590042151554 no 2266 0.331536170257128 3279 699517 SGTC_2390 9097792 176.6 µM -0.437768638151587 0.324816537513858 no 2267 0.330777003753371 3206 4497149 SGTC_3278 9139605 49.47 µM -0.439208750494298 0.324284846850266 no 2268 0.330255142562436 3331 7958859 SGTC_2421 5690543 90.72 µM -0.439322120522169 0.324243005733495 no 2269 0.330214074060279 3269 3397993 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.439569667787605 0.324151651963599 no 2270 0.330124406715542 3222 5379071 SGTC_1693 xanthone 101.9 µM -0.440381533906903 0.32385211872846 no 2271 0.329830398524148 3208 7020 An insecticide. SGTC_453 enantio-paf c16 10 µM -0.4411149618266 0.323581622840613 no 2272 0.329564886198603 3273 13871343 A lipid and platelet activating factor SGTC_3223 9129970 49.47 µM -0.441256154114162 0.323529560340568 no 2273 0.329513782247218 3151 17248386 SGTC_578 3460-0051 92 µM -0.443052229132398 0.322867586849817 no 2274 0.328863978615833 3320 2876744 SGTC_2110 5483698 200 µM -0.443463034211862 0.322716256496745 no 2275 0.328715425639157 3193 2848765 YHR062C RPP1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.444901072377214 0.322186750456736 no 2276 0.328195623816893 3169 16623 A steroid. SGTC_1571 st070080 73.4 µM -0.445464351418066 0.321979441372774 no 2277 0.327992108194566 3347 4315245 SGTC_504 lovastatin 124 µM -0.44664939398807 0.321543479484664 no 2278 0.327564112973383 3225 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_912 3474-0017 2.18 µM -0.447554678711488 0.321210602382394 no 2279 0.327237308899218 3330 3360550 SGTC_3128 9127691 49.47 µM -0.451261205502641 0.319849196293404 no 2280 0.32590065082548 3275 41316314 SGTC_1460 k062-0059 9.15 µM -0.451947892754499 0.319597241787584 no 2281 0.325653260570894 3125 1373085 SGTC_671 0560-0003 407 µM -0.452796895266342 0.31928584678584 no 2282 0.325347499740485 3196 3238678 SGTC_246 cycloheximide 667 µM -0.453773832607695 0.318927685856678 no 2283 0.324995809728129 3162 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2164 5685496 200 µM -0.454712577360367 0.318583686162963 no 2284 0.32465801560512 3326 759046 SGTC_856 0433-0016 11.3 µM -0.455581672870275 0.318265348514401 no 2285 0.324345412292116 3278 3911780 SGTC_2433 5607874 27.82 µM -0.4581971035338 0.317308162650796 no 2286 0.323405420317701 3193 2252428 SGTC_2266 7929956 200 µM -0.458379362454578 0.317241505611629 no 2287 0.323339957930849 3270 2967153 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.458907718313816 0.317048305026639 no 2288 0.323150217963561 3163 23665772 A membrane-active detergent. SGTC_564 3555-0129 330 µM -0.459727683831442 0.316748572111774 no 2289 0.32285584799958 3282 563260 SGTC_2215 7188065 200 µM -0.461127352420424 0.316237210535697 no 2290 0.322353619387703 3326 940217 SGTC_1256 0570-0116 285 µM -0.46188896845708 0.315959105608452 no 2291 0.322080472665034 3236 410638 SGTC_1755 st041960 45.185 µM -0.462459649197289 0.315750789144049 no 2292 0.321875866120584 3323 2257073 SGTC_3050 9093513 49.47 µM -0.463969658660591 0.315199870469522 no 2293 0.32133474199965 3261 25236664 SGTC_2790 5423970 71.43 µM -0.467032733808419 0.314083586859082 no 2294 0.320238229333402 3351 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1905 st060207 84.5 µM -0.467079802599571 0.314066446697831 no 2295 0.320221391962725 3193 1948547 SGTC_77 0828-0286 12.516 µM -0.467807339084939 0.31380156437349 no 2296 0.319961185903372 3323 745345 SGTC_1112 tnp00069 1.16933 µM -0.469449260946046 0.313204124300171 no 2297 0.319374272175016 3304 145826 SGTC_109 0132-0036 33.701 µM -0.470284769256392 0.312900298957644 no 2298 0.319075788801034 3251 67274 A color developer. SGTC_63 0099-0242 26.702 µM -0.472335453625972 0.312155124248361 no 2299 0.318343684072742 3349 3898502 YLR359W ADE13 SGTC_3141 9094609 49.47 µM -0.472394811965255 0.31213356612219 no 2300 0.3183225033878 3139 25236309 YDL196W YDL196W SGTC_2480 5767542 37.17 µM -0.472689405945376 0.312026583191822 no 2301 0.318217392957844 3226 2867358 SGTC_2216 7189485 200 µM -0.474181090421035 0.311485115791781 no 2302 0.31768538831912 3320 731273 SGTC_1061 3448-9325 110 µM -0.474208787162175 0.311475065985557 no 2303 0.317675513916599 3322 723482 SGTC_1334 1486-0610 236 µM -0.476579568867164 0.310615345353029 no 2304 0.316830767497684 3318 3742339 SGTC_3249 9135183 49.47 µM -0.47717176792528 0.310400756294393 no 2305 0.316619906512336 3374 4902779 SGTC_2886 9058944 51.95 µM -0.478290740603456 0.309995461891549 no 2306 0.316221642894415 3208 4949929 SGTC_1424 4048-1941 275 µM -0.478666683341543 0.30985934635767 no 2307 0.316087885541034 3359 X1424 SGTC_118 0083-0097 135.343 µM -0.480520945495161 0.309188365356077 no 2308 0.315428506610179 3367 5207356 SGTC_147 4466-0538 29.23 µM -0.482235218742068 0.308568606172013 no 2309 0.314819430368905 3433 6742687 YHR072W ERG7 SGTC_180 1486-1293 102.781 µM -0.483706719990487 0.308037050618808 no 2310 0.31429701168906 3420 4140536 SGTC_1270 0831-1170 17.3 µM -0.483929205041157 0.307956716561964 no 2311 0.314218056420911 3344 6764716 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.486073565307049 0.307182911327695 no 2312 0.313457504264567 3329 364106 SGTC_1873 rapamycin 2 nM -0.489308829637419 0.306017070797791 no 2313 0.312311535437382 3288 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_889 0919-1524 82.7 µM -0.48985264073544 0.305821298608235 no 2314 0.312119088830278 3321 3905452 SGTC_1870 st057514 26.5 µM -0.489938420461746 0.305790422940168 no 2315 0.312088737348493 3231 5393161 SGTC_2972 9093619 59.92 µM -0.490108090961299 0.305729355582044 no 2316 0.312028706510987 3208 25236256 SGTC_2368 9071271 200 µM -0.490684853230053 0.305521809230811 no 2317 0.311824680543898 3284 27209959 SGTC_1208 2323-2347 50.3 µM -0.491553274850739 0.305209427918678 no 2318 0.311517590867561 3374 5412760 SGTC_3333 9141820 12.094 µM -0.492692137133557 0.304799980948664 no 2319 0.311115067121117 3244 1939433 SGTC_827 3253-0474 693 µM -0.492700104593117 0.304797117325344 no 2320 0.311112251867297 3372 5402065 SGTC_1760 st045453 10.4495 µM -0.493708021360482 0.304434953557351 no 2321 0.310756199726137 3373 3323419 YIL048W NEO1 SGTC_1748 st037455 53.6035 µM -0.494065799089483 0.304306443254117 no 2322 0.310629855359484 3398 580690 SGTC_2170 morpholine 200 µM -0.494118439092144 0.304287537512509 no 2323 0.31061126813864 3369 121171 Reacts with secondary amines. SGTC_1911 st060208 74.3 µM -0.494348763493414 0.304204822285499 no 2324 0.310529946121429 3331 688783 SGTC_1403 3909-7815 62.9 µM -0.49454265341755 0.304135199352298 no 2325 0.310461495421097 3253 6615483 SGTC_2662 daunorubicin 22.37 µM -0.495032589493194 0.303959302380013 no 2326 0.310288558140512 3284 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_511 blebbistatin 171 µM -0.495034976375293 0.303958445552045 no 2327 0.310287715723229 3414 3476986 A myosin inhibitor. SGTC_1786 berberine 21.6 µM -0.495359026662087 0.303842130011724 no 2328 0.310173355863802 3334 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1829 berberine 14.4 µM -0.496105443076372 0.303574284731534 no 2329 0.309910009571856 3388 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3127 9126946 49.47 µM -0.496673869276458 0.303370380494212 no 2330 0.309709526141667 3285 27243249 SGTC_88 0180-0332 8.668 µM -0.496805094155072 0.303323316573898 no 2331 0.309663251278939 3262 3101745 SGTC_2897 9048598 12.99 µM -0.4970946899278 0.303219464339731 no 2332 0.309561139515845 3257 6467404 SGTC_551 k048-0028 34.9 µM -0.50047355975842 0.302008941255705 no 2333 0.30837083449801 3403 6836383 SGTC_2395 5646831 180.19 µM -0.500535366303913 0.301986818501855 no 2334 0.308349080046996 3419 6808628 SGTC_2866 9034245 58.44 µM -0.500804550212823 0.301890476527314 no 2335 0.308254341488385 3300 6462273 SGTC_374 0880-0231 82.3 µM -0.501395010498979 0.301679196867606 no 2336 0.30804657530278 3318 6833587 SGTC_1233 0325-0408 14.2 µM -0.501410248172938 0.301673745373375 no 2337 0.308041214412385 3376 12874 SGTC_2694 st077685 81.9 µM -0.501441941331955 0.301662406837594 no 2338 0.308030064314729 3214 2838096 SGTC_3083 9117465 49.47 µM -0.504145972652323 0.300695719982709 no 2339 0.307079401560269 3347 16420915 SGTC_1066 ketoconazole 628 nM -0.504165011439654 0.300688918605706 no 2340 0.307072712633598 3400 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_113 0099-0221 2.5 µM -0.504285960875508 0.300645712501134 no 2341 0.307030220780376 3440 89219 SGTC_44 0929-0055 61.211 µM -0.504953276719107 0.300407381318863 no 2342 0.306795826551727 3242 1379590 SGTC_2107 5363541 170.161 µM -0.50703212113314 0.299665471876888 no 2343 0.306066140427198 3377 244052 SGTC_863 0466-0191 129 µM -0.507058291388291 0.299656137384694 no 2344 0.306056959414517 3381 765160 YPR165W RHO1 SGTC_2137 5261020 140 µM -0.507114291732589 0.29963616344129 no 2345 0.306037313860539 3296 763655 SGTC_2483 5729050 27.16 µM -0.508134223280071 0.299272484572726 no 2346 0.305679607998266 3440 2865180 SGTC_422 cantharidin 155 µM -0.510477158320548 0.298437819260645 no 2347 0.304858606555114 3294 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1036 k216-0215 33.5 µM -0.510597181729388 0.298395089729079 no 2348 0.304816574852285 3369 622330 SGTC_352 k048-0007 5.11 µM -0.510708530169598 0.298355451062908 no 2349 0.304777583390936 3376 6811911 SGTC_704 1310-0270 142 µM -0.510742852886881 0.298343233083776 no 2350 0.304765564873896 3343 5718033 SGTC_608 k048-0125 159 µM -0.512033025673374 0.297884130999552 no 2351 0.304313948072941 3404 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_52 0329-0193 875 nM -0.513001858325352 0.297539588252169 no 2352 0.303975010388431 3473 3739292 SGTC_249 wiskostatin 11.211 µM -0.513207409848087 0.29746651204578 no 2353 0.303903121622688 3407 2775510 A n-wasp and actin depolymerizer. SGTC_1276 0871-0068 94.2 µM -0.513566262657938 0.297338954910732 no 2354 0.303777636056058 3340 3414906 SGTC_933 2914-0560 114 µM -0.513855956854152 0.297235998997655 no 2355 0.303676351110994 3429 463887 SGTC_3077 9117319 49.47 µM -0.514244393358501 0.297097976122222 no 2356 0.303540566839218 3379 17154678 SGTC_2059 5238311 157 µM -0.515579697671572 0.296623727048337 no 2357 0.303073996542016 3269 703021 SGTC_1092 toremifene 6.32 µM -0.516940120592059 0.296140913710646 no 2358 0.302598979745412 3355 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2568 diosmetin 100 µM -0.518852773547933 0.295462724774345 no 2359 0.301931706563775 3453 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1359 1582-0056 520 nM -0.519072659513335 0.295384803360648 no 2360 0.301855036648874 3406 3661189 SGTC_1100 amiodarone 5.07 µM -0.519883359664412 0.295097595704719 no 2361 0.301572437063257 3410 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2653 dihydrofissinolide 100 µM -0.520215567257171 0.294979941306371 no 2362 0.301456668182758 3398 6857746 SGTC_1358 1509-0022 2.48 µM -0.521454240140317 0.294541444465155 no 2363 0.301025187495762 3380 3258434 SGTC_2033 5192550 145 µM -0.521731202404474 0.294443439500711 no 2364 0.300928748248556 3315 182073 SGTC_2825 7998094 58.44 µM -0.521792385760411 0.294421791387848 no 2365 0.300907445864957 3332 2987815 SGTC_1626 st003712 1.76 µM -0.522018019229812 0.294341963302176 no 2366 0.300828892295073 3415 24207035 SGTC_3125 9127534 49.47 µM -0.522822855800164 0.294057297261006 no 2367 0.300548766399541 3341 1639235 SGTC_1474 0330-0125 5.35 µM -0.522966824936635 0.294006389630869 no 2368 0.300498669911549 3413 X1474 SGTC_3323 9138564 53.9225 µM -0.526161258229359 0.292877884549862 no 2369 0.29938808464817 3455 43912313 YNL103W MET4 SGTC_2149 5554786 194.827 µM -0.526163295505238 0.292877165478499 no 2370 0.299387376957609 3333 745063 YPR165W RHO1 SGTC_1039 k821-0043 94 µM -0.526754358502639 0.292668580103021 no 2371 0.299182090857941 3422 15992768 SGTC_924 2046-0044 21.3 µM -0.529546670042572 0.291684111199996 no 2372 0.298213139133757 3392 3623589 SGTC_2779 methotrexate 400 µM -0.529987369039235 0.291528877674136 no 2373 0.298060344155919 3448 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_176 1486-1328 72.834 µM -0.531173984114501 0.291111091419941 no 2374 0.297649109678785 3382 22310231 SGTC_3308 9128332 17.569 µM -0.531730232898537 0.290915342335833 no 2375 0.297456424736202 3445 17332805 YDL196W YDL196W SGTC_3068 9116768 49.47 µM -0.531935237973851 0.290843214673143 no 2376 0.297385425212205 3410 41904888 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.532905336576286 0.290502014868945 no 2377 0.297049555448812 3320 4174840 SGTC_2797 7859098 81.82 µM -0.532938806798303 0.290490246179436 no 2378 0.297037970408379 3333 972681 SGTC_1758 st042942 75.2445 µM -0.533549417820928 0.2902755843173 no 2379 0.296826656034913 3406 669317 SGTC_496 calpeptin 138 µM -0.535050027560088 0.28974835704231 no 2380 0.296307632047724 3380 73364 A calpain inhibitor. SGTC_1675 st018485 24.5 µM -0.535530970118862 0.289579476840832 no 2381 0.296141373957161 3346 3323024 SGTC_2918 7977171 22.06 µM -0.536467697842424 0.289250683041567 no 2382 0.295817677422796 3377 2236483 SGTC_365 0121-0052 13.6 µM -0.536811878522592 0.289129918849921 no 2383 0.295698782858663 3422 3101739 SGTC_1556 plumbagin 1.48 µM -0.537258667086187 0.288973187552471 no 2384 0.295544475956669 3400 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1997 st073024 93.8 µM -0.538991529917763 0.288365686014913 no 2385 0.294946349496873 3441 686268 SGTC_837 0091-0265 12.5 µM -0.539918263224309 0.288041042106224 no 2386 0.294626701149311 3331 759367 SGTC_286 k060-0067 22.9 µM -0.54131398644567 0.287552432159083 no 2387 0.294145590872139 3363 5985051 SGTC_913 3487-1245 167 µM -0.542564456825204 0.287115004904935 no 2388 0.293714858296255 3330 4016153 SGTC_999 SEC7.066 22.7 µM -0.545249131364017 0.286176944247986 no 2389 0.292791092345048 3385 740511 YDR170C SEC7 SGTC_2829 7992743 58.44 µM -0.545819279246068 0.285977914629307 no 2390 0.292595084743463 3401 16462845 SGTC_1271 0832-2808 169 µM -0.546476427055197 0.285748596358864 no 2391 0.292369243636732 3463 3663794 SGTC_645 0845-0943 5.41 µM -0.547214367141562 0.285491189124906 no 2392 0.292115733415098 3377 1885106 SGTC_1764 st044502 93.5 µM -0.548482136975962 0.285049225326415 no 2393 0.291680445726238 3451 8407 SGTC_1560 lithocholic acid 53.1 µM -0.549244501916486 0.284783610501253 no 2394 0.291418834026129 3405 9903 A bile acid which acts as a detergent. SGTC_3060 1327-0027 12.5 µM -0.549438618962664 0.284715997241245 no 2395 0.291352238679902 3384 16000455 YPR107C YTH1 SGTC_2290 7904846 200 µM -0.550467524337479 0.284357745345487 no 2396 0.290999372807899 3417 2962154 SGTC_1003 4049-0218 100 µM -0.550834155098786 0.284230141208165 no 2397 0.290873684068195 3503 295161 SGTC_3071 9117417 49.47 µM -0.550856948818695 0.284222208863583 no 2398 0.290865870739276 3329 45595590 YGL055W OLE1 SGTC_3296 9122258 64.045 µM -0.550898441832504 0.284207769329738 no 2399 0.290851647838158 3429 4730474 SGTC_1664 st014217 9.02 µM -0.556326716109619 0.282321765520093 no 2400 0.288993763398657 3509 3982782 SGTC_111 0083-0039 52.457 µM -0.557272392950108 0.281993815752374 no 2401 0.288670667404835 3399 759313 SGTC_1935 st074532 41.6 µM -0.557744436938137 0.281830185049401 no 2402 0.288509454509902 3465 2829742 SGTC_2964 9083345 53.42 µM -0.559502610174596 0.281221129675979 no 2403 0.287909375174089 3377 17741579 SGTC_3152 9099253 49.47 µM -0.559698150778368 0.28115343101686 no 2404 0.287842671954426 3458 25236131 SGTC_1393 3470-5649 58.2 µM -0.560118311584732 0.281007992602032 no 2405 0.287699370518046 3385 4108395 SGTC_3260 9137109 49.47 µM -0.56089921248388 0.280737780828362 no 2406 0.28743312346055 3372 17478346 SGTC_2551 apiole 73.87 µM -0.56131410113562 0.280594269831698 no 2407 0.287291715182267 3367 10659 A possible DNA adduct former. SGTC_2641 levomentholum 100 µM -0.564485708058835 0.279498377694847 no 2408 0.286211811985534 3431 16666 SGTC_716 1683-5115 658 µM -0.565430146463156 0.279172445933469 no 2409 0.285890612242709 3498 723597 SGTC_3304 9125678 46.087 µM -0.565607813389598 0.279111152589513 no 2410 0.285830207585673 3414 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1937 st074714 47.2 µM -0.565755106914809 0.279060342731756 no 2411 0.285780134128286 3332 17250970 SGTC_67 0335-0847 266 µM -0.566117954981907 0.278935195126644 no 2412 0.285656799208102 3569 4552207 YOR254C SEC63 SGTC_1882 5615643 20 µM -0.566292180798985 0.278875113718821 no 2413 0.285597587479912 3425 2253075 SGTC_2805 7950783 58.44 µM -0.569818216225511 0.277660522968293 no 2414 0.284400499537617 3455 1178958 YDL195W SEC31 SGTC_3069 9117009 49.47 µM -0.57065762041197 0.277371760069562 no 2415 0.284115875784503 3358 41904981 SGTC_3187 9109394 49.47 µM -0.570802143465104 0.277322057606936 no 2416 0.2840668849025 3403 17098090 SGTC_21 0849-0113 22.993 µM -0.571118943571357 0.277213123131547 no 2417 0.283959509139289 3430 1560156 SGTC_2943 9068529 45.32 µM -0.571185815017903 0.277190131478191 no 2418 0.283936846312075 3505 3270634 SGTC_3094 9117742 49.47 µM -0.571381140143519 0.277122980391317 no 2419 0.283870655309507 3441 17149698 SGTC_2688 kanamycin b 96.69 µM -0.572580701178261 0.276710756342012 no 2420 0.283464314880185 3590 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_302 1094-0063 18.9 µM -0.573229436797387 0.276487946353615 no 2421 0.283244677785838 3390 5440289 SGTC_3257 9139206 32.98 µM -0.57416822237587 0.276165673766621 no 2422 0.282926985464694 3459 4910041 SGTC_2946 9065502 71.43 µM -0.577205476231666 0.275124289896608 no 2423 0.281900329067193 3354 16489101 SGTC_892 0929-0076 29 µM -0.577656313547526 0.274969876200027 no 2424 0.281748089588661 3430 5751038 SGTC_3181 9108277 49.47 µM -0.578475871176378 0.274689283638869 no 2425 0.281471441582491 3406 17097298 SGTC_212 3807-4682 38.772 µM -0.579098187644781 0.27447631503972 no 2426 0.281261461433349 3501 3125501 YBL034C STU1 SGTC_1394 3474-0001 65.7 µM -0.5797382057064 0.274257373639814 no 2427 0.281045587384729 3403 5017666 YIL048W NEO1 SGTC_2581 avocatin a 64 µM -0.584446458470663 0.272649400702105 no 2428 0.279459988801973 3430 6710728 A skin care supplement. SGTC_952 1185-0122 232 µM -0.585573951176701 0.272265032460835 no 2429 0.279080928779081 3471 678600 SGTC_3011 9081274 71.4286 µM -0.585926314582589 0.272144965154416 no 2430 0.278962516443764 3438 6625322 SGTC_1012 4112-3522 18 µM -0.585934756234889 0.272142088996822 no 2431 0.27895967991162 3507 3112398 SGTC_635 k038-0028 24.7 µM -0.586045721393763 0.272104283432919 no 2432 0.278922395122149 3456 4035102 SGTC_3299 9121982 43.1275 µM -0.587492944864652 0.271611457082932 no 2433 0.2784363436945 3455 17594604 YPL160W CDC60 SGTC_1821 st053465 65.6 µM -0.588043571216445 0.271424067805557 no 2434 0.278251523737159 3459 675086 SGTC_2053 5265679 138 µM -0.588284746183922 0.271342011378325 no 2435 0.278170591226743 3451 764595 SGTC_958 1222-0007 33 µM -0.58838196285444 0.27130893825507 no 2436 0.278137970900362 3561 7312461 SGTC_1361 1608-0041 5.61 µM -0.588993809720709 0.271100833999747 no 2437 0.277932713095126 3489 X1361 SGTC_2478 5763493 32.33 µM -0.589938216197491 0.270779774340867 no 2438 0.27761603587705 3465 1365576 YLR208W SEC13 SGTC_390 dec-rvkr-cmk 16.7 µM -0.590661501252418 0.270534015358442 no 2439 0.277373624084466 3477 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2576 guaiol 23.12 µM -0.591642841081678 0.270200752360313 no 2440 0.277044889790743 3469 227829 SGTC_918 glabranin 770.725 nM -0.592184966124816 0.270016734779816 no 2441 0.276863367745826 3487 124049 Also referred to as licorice root. SGTC_2598 perillyl alcohol 100 µM -0.593151906057883 0.269688674836828 no 2442 0.276539747780545 3520 10819 An apoptosis inducer. SGTC_3114 9122766 49.47 µM -0.593286151399117 0.269643144342806 no 2443 0.276494832588567 3464 17176985 SGTC_1441 4106-0040 13 µM -0.593553933293109 0.269552335249708 no 2444 0.276405250032676 3512 2904180 SGTC_430 0958-0115 16.4 µM -0.59390407487057 0.269433619804239 no 2445 0.276288136716775 3405 6833180 SGTC_3222 9128301 49.47 µM -0.594246800623308 0.269317444081145 no 2446 0.276173527385763 3464 4911358 SGTC_1297 1068-0111 14.1 µM -0.594980807226833 0.269068718172648 no 2447 0.275928150168304 3452 767057 SGTC_2899 9053889 58.44 µM -0.596068715356381 0.268700281160458 no 2448 0.275564661345234 3498 6470052 SGTC_1005 4092-0690 4.4 µM -0.597491695360444 0.268218749745486 no 2449 0.275089574959714 3452 1529343 SGTC_1697 st025554 27.742 µM -0.597575396300186 0.268190439169542 no 2450 0.27506164252628 3500 1269519 SGTC_1421 4029-0249 71.4 µM -0.599330661996492 0.267597093730569 no 2451 0.274476202416552 3581 2894095 SGTC_2021 4019055 173 µM -0.601032914445805 0.267022301515373 no 2452 0.273909031939618 3560 44827708 YER133W GLC7 SGTC_2486 5283202 22.39 µM -0.601175977762802 0.26697402236174 no 2453 0.273861391332077 3445 1377751 SGTC_2373 9071805 200 µM -0.602114658946789 0.266657357808554 no 2454 0.273548908730333 3543 10149009 SGTC_1331 1472-0049 76.2 µM -0.602119175651717 0.266655834555124 no 2455 0.273547405566956 3465 24051409 SGTC_3228 9131799 49.47 µM -0.602382163446008 0.266567149816214 no 2456 0.273459890046696 3471 17015818 SGTC_1960 st011366 51.8 µM -0.604157487566611 0.26596886550679 no 2457 0.272869471060785 3536 3972846 SGTC_986 1493-0483 84 µM -0.604487138848717 0.265857847942176 no 2458 0.272759908676158 3493 40079 SGTC_438 sphingosine 6.67 µM -0.605014544902141 0.265680280816424 no 2459 0.272584666230169 3362 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2237 6667747 47.222 µM -0.60581010160037 0.265412546520261 no 2460 0.272320430524728 3380 729940 YDL015C TSC13 SGTC_2907 7721985 69.9 µM -0.606531756502087 0.265169801399678 no 2461 0.272080850641088 3489 3267881 SGTC_3142 9086498 49.47 µM -0.60935377294037 0.264221635393807 no 2462 0.271144985849636 3454 25236367 SGTC_3195 9113082 49.47 µM -0.611305999143182 0.263566721062048 no 2463 0.27049851007555 3522 17018038 SGTC_562 3772-2733 112 µM -0.611716131471493 0.263429239122816 no 2464 0.270362793537642 3552 2876874 YIL048W NEO1 SGTC_1793 st048256 72.231 µM -0.613149959872887 0.262948888203429 no 2465 0.269888594262401 3499 672022 SGTC_1019 4262-0212 3.4 µM -0.613756057853473 0.262745972328983 no 2466 0.26968826930854 3561 4677213 SGTC_535 2293-4129 48.2 µM -0.614699825364341 0.262430167431766 no 2467 0.269376487591991 3558 396118 YIL048W NEO1 SGTC_1272 0839-0021 27 µM -0.615449830686374 0.26217933819152 no 2468 0.269128845820347 3527 5027250 SGTC_1342 1486-1464 234 µM -0.615966010941083 0.26200678000677 no 2469 0.268958476360286 3569 3253938 SGTC_920 mycophenolic acid 780.421 nM -0.617159123989129 0.261608147276099 no 2470 0.268564887088838 3513 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_247 mechlorethamine 29.705 µM -0.617244934040005 0.261579489159425 no 2471 0.26853659086289 3489 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2182 6325192 200 µM -0.619147816074702 0.260944395014475 no 2472 0.267909492836236 3518 736248 SGTC_1122 capsaicin 818.572 nM -0.620107945778759 0.260624249314786 no 2473 0.267593360639107 3557 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1427 4048-4900 550 nM -0.620786268868002 0.260398191164961 no 2474 0.267370129472576 3557 24132586 SGTC_70 0141-0289 43.283 µM -0.621352301868566 0.260209632173501 no 2475 0.267183924082655 3550 352408 SGTC_2475 5812728 15.03 µM -0.623600153631956 0.25946151474687 no 2476 0.266445104851631 3564 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1754 st042065 16.137 µM -0.623869658455977 0.259371894301002 no 2477 0.266356594002061 3531 1126236 YIL048W NEO1 SGTC_1408 3909-7976 48.8 µM -0.624256800564321 0.259243183046077 no 2478 0.266229474724839 3556 24152374 SGTC_848 0368-0089 85.6 µM -0.625875962232694 0.258705226200972 no 2479 0.26569815114425 3546 762535 SGTC_720 r052-1644 49.9 µM -0.625992529102909 0.258666519860552 no 2480 0.265659920793282 3550 1422863 YOR257W CDC31 SGTC_884 0851-0618 334 µM -0.62716615242976 0.258276982213866 no 2481 0.265275163895795 3564 9642473 SGTC_2800 7887935 81.82 µM -0.627241806489925 0.258251882288719 no 2482 0.265250371421286 3542 2961002 SGTC_1240 0356-0016 42.1 µM -0.629483441395855 0.257508743948769 no 2483 0.26451630296141 3515 4305613 SGTC_292 k038-0015 474 µM -0.630651842944798 0.257121840718135 no 2484 0.264134096586245 3558 46368540 SGTC_2425 5628681 7.85 µM -0.630876669584153 0.25704742656269 no 2485 0.264060583803536 3560 5714958 SGTC_452 diindolylmethane 8 µM -0.631420781936096 0.256867380123567 no 2486 0.263882715598091 3550 3071 Inhibits expression of several cancer promoting factors. SGTC_1435 4092-0789 56.7 µM -0.631690817622144 0.256778049856519 no 2487 0.26379446466918 3573 2248285 SGTC_3012 9080433 71.4286 µM -0.631932488214738 0.256698116735459 no 2488 0.263715496559642 3590 17688859 SGTC_485 niflumic acid 177 µM -0.632338282778923 0.25656392836776 no 2489 0.263582926544521 3578 4488 A COX2 inhibitor. SGTC_301 4119-0100 24.5 µM -0.633881099443372 0.256054082628541 no 2490 0.263079210606276 3556 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2954 9074818 52.69 µM -0.63508210746644 0.255657558563823 no 2491 0.262687432947956 3568 16648742 SGTC_1434 4073-0095 163 µM -0.636112176337442 0.255317727294759 no 2492 0.262351654849312 3573 24133745 SGTC_2329 6138490 200 µM -0.638043377433856 0.254681239303296 no 2493 0.261722721841196 3567 720019 SGTC_2249 haloperidol 116.36 µM -0.638348730575681 0.254580676714282 no 2494 0.261623348556521 3590 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_92 0063-0024 660.874 µM -0.638860931997069 0.254412039067389 no 2495 0.261456702632876 3631 3594437 SGTC_883 0850-0245 24.6 µM -0.638947712638837 0.254383473133261 no 2496 0.261428473749817 3609 6823229 YPR165W RHO1 SGTC_764 1951-2361 146 µM -0.639465827620948 0.254212958119504 no 2497 0.261259968651989 3534 5438930 SGTC_2962 9082311 13.18 µM -0.639570040786894 0.25417866812951 no 2498 0.26122608243523 3541 16459453 SGTC_3066 9117245 49.47 µM -0.640012514895808 0.254033104782738 no 2499 0.261082231588788 3599 17176980 SGTC_257 daunorubicin 18.5 µM -0.640246922981288 0.253956007882229 no 2500 0.261006040692186 3602 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2893 9048488 25.97 µM -0.640637484623292 0.253827579299871 no 2501 0.260879119778487 3527 6467338 SGTC_1632 st005650 90 µM -0.640641169666848 0.253826367707516 no 2502 0.26087792240016 3563 2759605 SGTC_604 1000-0114 314 µM -0.642132744465038 0.25333620755514 no 2503 0.260393498403096 3619 1572745 SGTC_146 3448-8650 53.125 µM -0.643390456846329 0.252923286088221 no 2504 0.259985387087362 3585 2891488 YIL048W NEO1 SGTC_1698 5-fluorocytosine 1.055 µM -0.647515479616728 0.251571483551524 no 2505 0.25864918967767 3607 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1412 3909-8563 178 µM -0.647935194208889 0.251434154026893 no 2506 0.258513433244937 3652 23767530 SGTC_117 lucigenin 22.078 µM -0.648335115067054 0.251303337831492 no 2507 0.258384113426802 3584 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2191 5911152 200 µM -0.648627689961029 0.251207657857058 no 2508 0.258289526612589 3558 2875902 SGTC_2284 7945075 39.21 µM -0.64877291917829 0.251160171095677 no 2509 0.25824258198707 3630 1245402 SGTC_1473 k844-0725 134 µM -0.650510743730883 0.250592309189745 no 2510 0.257681182083403 3660 54682906 SGTC_2541 muurolladie-3-one 83.07 µM -0.650534818497628 0.250584447154829 no 2511 0.257673409241962 3621 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1195 1502-0147 41.1 µM -0.650664792450616 0.250542004151071 no 2512 0.257631447618155 3614 817940 SGTC_2495 cafestol 54.53 µM -0.651006284151754 0.25043050816408 no 2513 0.257521215159936 3618 16667697 An anti-infammatory. SGTC_662 k832-1615 104 µM -0.651419659200285 0.250295577677054 no 2514 0.257387811764772 3580 5878478 SGTC_3288 9119690 36.221 µM -0.65232659185887 0.249999679274407 no 2515 0.257095254518221 3565 17595618 YKL019W RAM2 SGTC_3041 9091929 49.47 µM -0.653828237390193 0.249510156576155 no 2516 0.256611236000929 3656 25236887 SGTC_2627 acetyl isogambogic acid 100 µM -0.657041380330828 0.248464414643245 no 2517 0.255577154706351 3567 6857789 A caspase activator and apoptosis inducer. SGTC_1903 st060211 78.3 µM -0.657922454583851 0.248178070872108 no 2518 0.255293980545539 3641 688960 SGTC_1052 3253-3998 198 µM -0.659279728282979 0.247737309790774 no 2519 0.254858078715174 3593 5450317 SGTC_1090 efavirenz 20.7 µM -0.659862076011795 0.247548326403412 no 2520 0.254671171500998 3630 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_787 4152-0075 138 µM -0.66037631275464 0.247381510437438 no 2521 0.254506184525602 3606 9566539 SGTC_1170 0310-0127 64.8 µM -0.660470765347238 0.24735087699617 no 2522 0.254475886580733 3585 774975 SGTC_1261 0712-0010 12.7 µM -0.661979452732023 0.246861845279959 no 2523 0.253992195054431 3633 2840123 SGTC_1650 st011916 45.8 µM -0.662139977935573 0.246809842503342 no 2524 0.253940758407458 3606 242528 SGTC_3312 9133330 71.43 µM -0.662582451018878 0.246666531958361 no 2525 0.253799006286253 3640 17617324 SGTC_1674 st016616 23.6 µM -0.663045247064955 0.246516686798869 no 2526 0.253650787893271 3602 625830 SGTC_898 1000-0849 28.3 µM -0.66316664840713 0.246477387271595 no 2527 0.253611914553922 3591 6751807 SGTC_649 1123-0311 367 µM -0.664386331232671 0.246082743076095 no 2528 0.253221539504281 3600 693629 YIL048W NEO1 SGTC_1047 2043-3044 82 µM -0.664392956852354 0.246080600196928 no 2529 0.253219419753403 3608 669592 SGTC_1390 3413-2614 145 µM -0.664434029465295 0.246067316584073 no 2530 0.253206279499058 3634 3421432 SGTC_412 gemfibrozil 100 µM -0.664846051077438 0.245934082759334 no 2531 0.253074482338811 3604 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1953 st076800 12.1 µM -0.664992276216797 0.245886807814223 no 2532 0.253027716630611 3585 297591 SGTC_959 1222-0044 107 µM -0.665480209593907 0.245729093056681 no 2533 0.252871698736572 3608 6083612 SGTC_2570 licareol 100 µM -0.665572412265063 0.245699296480231 no 2534 0.252842222395831 3570 443158 SGTC_954 1189-0853 2.85 µM -0.666602484679931 0.245366546191547 no 2535 0.252513040793205 3610 2828194 SGTC_2300 7976697 71.57 µM -0.667324545904915 0.24513343902407 no 2536 0.252282425431049 3551 2236109 SGTC_1217 1183-1422 255 µM -0.667773192597366 0.244988659852093 no 2537 0.252139190462683 3647 2849664 SGTC_2875 9039966 71.43 µM -0.669840272996444 0.244322203610109 no 2538 0.251479808747411 3655 6463691 SGTC_1304 1165-0502 251 µM -0.67017595203609 0.244214068196457 no 2539 0.251372815952697 3622 767425 SGTC_1053 3366-3204 134 µM -0.670466509763652 0.244120488968895 no 2540 0.251280224349155 3599 3632071 YPR165W RHO1 SGTC_1242 0402-0103 60.1 µM -0.670575571788809 0.244085368617215 no 2541 0.251245474369311 3597 432868 SGTC_3234 9132280 49.47 µM -0.671790638049418 0.243694275132954 no 2542 0.250858494783191 3635 17612295 SGTC_108 0509-0257 621.132 µM -0.672247098971996 0.243547441485341 no 2543 0.250713200695941 3620 536624 SGTC_3042 9091578 49.47 µM -0.672780494701889 0.243375920130125 no 2544 0.250543474307091 3596 25236497 SGTC_1157 4092-0394 27.6 µM -0.672835316157443 0.243358295173043 no 2545 0.250526033584162 3713 3659885 SGTC_1735 st034310 56.75 µM -0.673683248000724 0.243085775123889 no 2546 0.250256357195663 3662 871153 SGTC_735 3076-0345 636 µM -0.675105282741633 0.242629112672947 no 2547 0.249804438788071 3663 2888990 SGTC_3347 9188721 44.724 µM -0.676196462070242 0.242279014068059 no 2548 0.249457959260871 3634 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1785 bathophenanthroline 24 µM -0.677022146147682 0.242014280161313 no 2549 0.249195951636571 3590 72812 An iron chelator. SGTC_1715 st032160 10.2275 µM -0.677376262616877 0.24190079010816 no 2550 0.249083627591796 3575 5289825 SGTC_2730 imipramine 71.33 µM -0.677380967062226 0.241899282584582 no 2551 0.249082135545615 3659 3696 A tricyclic antidepressant. SGTC_603 3794-0023 45.9 µM -0.678120642541551 0.241662319495238 no 2552 0.248847601695809 3623 3802260 SGTC_2700 st077718 96.8 µM -0.679295696420193 0.241286137443761 no 2553 0.248475261356811 3632 904970 SGTC_2245 6637752 200 µM -0.679764858836715 0.241136028604507 no 2554 0.248326680429459 3609 681890 SGTC_1776 st049249 45.9 µM -0.680073256992595 0.24103738406193 no 2555 0.248229038386954 3644 1822314 SGTC_1526 st051518 75 µM -0.682048287649812 0.240406169337666 no 2556 0.247604208962438 3619 673993 SGTC_3162 9099653 49.47 µM -0.684169630930654 0.239729197594773 no 2557 0.246934028360155 3626 25237511 SGTC_1378 2093-0007 380 nM -0.685861009820403 0.239190184058368 no 2558 0.246400379639883 3669 3618014 SGTC_142 0335-0849 62.6745 µM -0.685866465224163 0.239188446586597 no 2559 0.246398659400312 3676 3889043 YPR107C YTH1 SGTC_337 1315-0038 354 µM -0.686513048849912 0.238982567368528 no 2560 0.246194819311597 3660 1626437 SGTC_2263 7948595 193.29 µM -0.688328256640297 0.238405103741216 no 2561 0.245623045749423 3653 2971371 SGTC_2277 7947813 106.88 µM -0.688568887717911 0.238328610293122 no 2562 0.245547302773758 3710 1246798 SGTC_1215 3852-0577 11.2 µM -0.688818369296494 0.238249317582563 no 2563 0.245468787192882 3713 2884876 SGTC_885 0865-0106 16.8 µM -0.689046492445939 0.238176825870642 no 2564 0.245397005237205 3625 2793380 SGTC_2711 st079103 59.1 µM -0.689211463067112 0.238124409950572 no 2565 0.245345102086437 3650 54693780 SGTC_2552 juarezic acid 87.02 µM -0.690321617498115 0.237771846348904 no 2566 0.244995978173184 3716 1549512 SGTC_1987 st072290 61.9 µM -0.691470868677048 0.237407168201732 no 2567 0.244634840775404 3666 54697379 SGTC_2049 5262831 67.185 µM -0.691683350587728 0.23733977750768 no 2568 0.24456810248381 3693 763417 SGTC_1938 st074717 56.4 µM -0.692151953021397 0.237191192847146 no 2569 0.244420954148295 3574 17250979 SGTC_57 miconazole 162.5 nM -0.693077621962574 0.236897831571073 no 2570 0.244130420185176 3603 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_881 0833-0569 170 µM -0.694667231157807 0.23639452130965 no 2571 0.243631934229482 3660 5418700 SGTC_2341 7987486 176.74 µM -0.695906113116144 0.236002668635047 no 2572 0.24324381434951 3669 1258686 SGTC_792 4534-1957 155 µM -0.69652809193797 0.23580607463018 no 2573 0.243049085441651 3664 1717904 SGTC_65 0798-0905 34.986 µM -0.696542741797536 0.235801445216194 no 2574 0.243044499885378 3769 3602145 SGTC_502 l-744,832 89.3 µM -0.697510628726363 0.235495700134508 no 2575 0.242741645044371 3636 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2194 5927483 104.545 µM -0.700200125137724 0.234647266658471 no 2576 0.241901166738893 3697 760979 SGTC_2100 5377183 190 µM -0.703383535226876 0.233645210539285 no 2577 0.240908382237917 3712 2844202 SGTC_1004 4084-0029 199 µM -0.70351694091949 0.233603269697928 no 2578 0.240866826518904 3686 716894 YLR208W SEC13 SGTC_2335 9018011 154.17 µM -0.703674452810174 0.233553755587512 no 2579 0.240817766767788 3716 6458208 SGTC_2671 danthron 100 µM -0.704266465917115 0.233367707393793 no 2580 0.240633422868628 3658 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_747 3448-8087 38.7 µM -0.70446040474662 0.233306777357351 no 2581 0.240573049968009 3703 5168703 SGTC_1993 st073995 70.8 µM -0.706339023731163 0.23271702611713 no 2582 0.239988665432308 3691 3098394 SGTC_441 propafenone 146 µM -0.706441391632743 0.232684913779956 no 2583 0.239956843965905 3659 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2744 captopril 92.04 µM -0.706497566190834 0.23266729312758 no 2584 0.239939382860558 3653 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1372 2752-0194 270 µM -0.70726373675306 0.232427037300482 no 2585 0.239701298245036 3665 823334 SGTC_2118 5526350 200 µM -0.709508540632929 0.231723906528415 no 2586 0.239004476704081 3714 743594 SGTC_1406 3909-7906 11.9 µM -0.71094971635097 0.231273118357688 no 2587 0.238557698069754 3698 X1406 SGTC_2566 crystal violet carbinol 226 nM -0.71162324250729 0.231062612643113 no 2588 0.238349055194193 3653 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2748 diazoxide 86.69 µM -0.712148072842104 0.230898654888164 no 2589 0.238186544159558 3647 3019 A potassium channel activatior. SGTC_2809 7964133 12.99 µM -0.712403933762386 0.230818747127123 no 2590 0.23810734014949 3721 1253665 SGTC_492 tmb-8 126 µM -0.713553713626664 0.230459850815266 no 2591 0.237751593855713 3589 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3082 9117008 49.47 µM -0.713607484645876 0.230443074179817 no 2592 0.23773496403559 3743 41448529 SGTC_2223 6903751 107.57 µM -0.71386777517659 0.230361872811267 no 2593 0.237654472728172 3654 5598863 SGTC_101 0490-5701 117.494 µM -0.715508962688224 0.229850249415166 no 2594 0.237147302333752 3598 4661669 SGTC_786 4544-0069 423 µM -0.715569034932666 0.229831534584918 no 2595 0.237128749707624 3746 748821 YLR208W SEC13 SGTC_2942 9052777 62.25 µM -0.715675544784357 0.229798354739284 no 2596 0.237095857317733 3787 6469503 SGTC_2212 7123476 200 µM -0.716259883552933 0.229616369822195 no 2597 0.236915446337139 3653 1085715 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.718071950589406 0.229052538152604 no 2598 0.236356462026565 3752 65057 A dermal irritant. YDR527W RBA50 SGTC_1204 4049-0315 18.3 µM -0.718959804414375 0.228776562759809 no 2599 0.236082843188566 3766 588402 SGTC_527 4476-4215 268 µM -0.720159464851737 0.228403963873285 no 2600 0.235713409141954 3704 4418754 SGTC_2773 thioridazine 9.09 µM -0.721121730227582 0.228105343410774 no 2601 0.23541731120019 3717 5452 An antipsychotic. SGTC_756 0508-1999 28.3 µM -0.721771531543229 0.227903814380397 no 2602 0.235217477507181 3692 6753853 SGTC_1388 3346-4487 254 µM -0.723969755828026 0.227222801447971 no 2603 0.234542151493794 3768 3345614 SGTC_1727 st034309 9.9045 µM -0.72687626044567 0.226324125550857 no 2604 0.233650880519039 3744 870305 SGTC_1685 st024049 53.0905 µM -0.727126761484651 0.226246766036903 no 2605 0.233574153114844 3719 1941139 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.72730385331762 0.226192085705215 no 2606 0.23351991907011 3712 551469 SGTC_2999 9069765 71.4286 µM -0.729183755237942 0.225612092287316 no 2607 0.232944633383997 3744 2097066 SGTC_2367 9070478 135.38 µM -0.730122786349888 0.225322694835616 no 2608 0.232657567108681 3699 572802 SGTC_229 benomyl 22.8748 µM -0.730973890429984 0.225060577081379 no 2609 0.232397550517883 3736 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1853 st056710 91.2 µM -0.732491779188818 0.224593536239491 no 2610 0.231934229283025 3808 269167 SGTC_779 1360-0071 233 µM -0.734959891683173 0.223835295150983 no 2611 0.231181960628132 3775 7566 SGTC_2247 cerulenin 830 nM -0.736853336022618 0.223254588285495 no 2612 0.23060577206281 3755 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3058 9093861 49.47 µM -0.737519726140724 0.223050415027524 no 2613 0.230403175884276 3735 17217477 SGTC_2056 5235370 200 µM -0.737793386945381 0.222966599728649 no 2614 0.230320006253376 3724 5511916 SGTC_554 4483-2211 187 µM -0.738133457997193 0.222862469673083 no 2615 0.230216676947791 3753 747107 SGTC_2435 5706476 10.6 µM -0.73849960063908 0.222750387454417 no 2616 0.230105454880952 3734 5725375 SGTC_1769 st044406 64.4 µM -0.739022606117898 0.222590342699293 no 2617 0.229946635209394 3748 670903 SGTC_1969 st069479 40.1 µM -0.739522082429982 0.222437559317033 no 2618 0.22979501787096 3704 3895485 SGTC_2531 methyl deoxycholate 70.07 µM -0.739921914723764 0.222315298873075 no 2619 0.229673688085256 3726 16667744 Haematoxylin. SGTC_2238 6671620 73.2395 µM -0.739986602811273 0.222295522197777 no 2620 0.229654061748431 3714 729941 SGTC_589 1227-0070 34.1 µM -0.740008533916194 0.222288817569162 no 2621 0.229647408074244 3743 2841384 SGTC_2977 9011197 71.43 µM -0.740640272250597 0.222095736345414 no 2622 0.229455791449653 3747 2704722 SGTC_2816 7982706 58.44 µM -0.740977960200779 0.221992566429297 no 2623 0.229353401901759 3763 2981853 SGTC_769 0302-0231 76 µM -0.741142694795668 0.221942246894855 no 2624 0.229303462419137 3728 571869 YER009W NTF2 SGTC_2820 7989630 71.43 µM -0.742572349169372 0.221505820857266 no 2625 0.228870317163821 3628 2984098 SGTC_2121 5257820 149.641 µM -0.742798875484272 0.221436714941833 no 2626 0.228801728201326 3807 791256 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.743756875084876 0.221144596312989 no 2627 0.228511787097876 3757 521171 SGTC_1385 3091-4834 14.1 µM -0.743771652602853 0.22114009199648 no 2628 0.228507316260172 3726 4072814 SGTC_3020 9089140 49.47 µM -0.744729703740278 0.220848181681887 no 2629 0.228217569277196 3785 17217859 SGTC_465 cgp-37157 41 µM -0.745723187234571 0.220545708565964 no 2630 0.227917324619142 3684 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_916 4466-0038 42 nM -0.745759406470264 0.220534685848473 no 2631 0.227906382857887 3822 5722064 YGL116W CDC20 SGTC_3220 9131269 49.47 µM -0.746354820310225 0.220353526877446 no 2632 0.227726551853538 3788 17722206 SGTC_3170 9103054 49.47 µM -0.746706438576781 0.220246584550959 no 2633 0.22762039119521 3735 16432970 SGTC_1246 0422-0085 105 µM -0.747124085341547 0.220119598777985 no 2634 0.227494331410758 3747 264295 SGTC_1569 carminic acid 40.6 µM -0.747249801117904 0.22008138303816 no 2635 0.227456393878536 3778 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_832 4083-0019 164 µM -0.747831891418569 0.219904485797334 no 2636 0.227280781636607 3833 1990758 SGTC_2052 5265182 7.135 µM -0.750647589918433 0.219049947880485 no 2637 0.226432386176008 3753 1239884 SGTC_200 k038-0079 37.545 µM -0.752387449658482 0.218522872834921 no 2638 0.225909045887139 3713 3436683 SGTC_1491 4138-0063 26.5 µM -0.752766161432208 0.218408242321896 no 2639 0.225795222163892 3711 23883227 SGTC_1915 st067105 30.6 µM -0.753840283845242 0.218083309666191 no 2640 0.225472565815306 3741 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2941 9056145 11.23 µM -0.756039282135017 0.217418960820427 no 2641 0.224812822030375 3643 2119517 SGTC_3017 9080681 49.47 µM -0.75609390957985 0.217402471975165 no 2642 0.224796446641536 3787 16451914 SGTC_1340 1486-1359 257 µM -0.757320583904204 0.217032400592331 no 2643 0.224428910926935 3713 4309068 SGTC_532 1548-0774 215 µM -0.757775442787475 0.216895268272266 no 2644 0.224292712997523 3859 5932993 SGTC_269 exalamide 29 µM -0.758347484107574 0.216722878541109 no 2645 0.224121493884918 3726 3316 A derivative of salicylamide. SGTC_68 0986-0284 82.829 µM -0.759089284012843 0.216499448595624 no 2646 0.223899574496375 3835 423278 YIL048W NEO1 SGTC_310 1273-0058 1.06 µM -0.760426369858716 0.216097055490259 no 2647 0.223499882900113 3743 2734232 SGTC_1738 st035555 74 µM -0.761910095749384 0.215651038825088 no 2648 0.223056832033826 3803 5331140 SGTC_2376 9072922 81.32 µM -0.761984707783072 0.215628624116136 no 2649 0.223034565577423 3789 17087968 SGTC_2221 6807166 181.081 µM -0.763497680567144 0.215174393177087 no 2650 0.222583322536464 3717 674925 SGTC_1305 1181-0477 144 µM -0.764483202561061 0.214878814658209 no 2651 0.222289671475081 3791 6252086 SGTC_216 k038-0035 28.382 µM -0.765893017180904 0.214456392248334 no 2652 0.221869980565757 3694 4444231 YPR107C YTH1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.766307176171945 0.214332389711164 no 2653 0.221746774692659 3764 61125 An anti-inflammatory. SGTC_1705 st027868 56.3335 µM -0.766662703811469 0.214225975145841 no 2654 0.221641041922202 3789 292948 SGTC_1739 st037196 92.5 µM -0.767553111534338 0.213959598163541 no 2655 0.221376364011457 3787 612214 SGTC_2935 9038016 29.96 µM -0.768534570711962 0.213666205485262 no 2656 0.221084830138755 3784 6463195 SGTC_1143 3454-2408 5.08 µM -0.77191428876859 0.212657683686064 no 2657 0.220082596920892 3737 X1143 SGTC_1391 3442-0225 151 µM -0.772757217716434 0.2124065839969 no 2658 0.2198330385432 3743 5227075 SGTC_1520 flindersine 88 µM -0.773335294768183 0.212234481094251 no 2659 0.219661986411915 3900 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2048 5246248 200 µM -0.773606332338838 0.212153816894803 no 2660 0.219581813126146 3760 677046 SGTC_1973 st070275 50.2 µM -0.774178657056052 0.211983544737217 no 2661 0.219412573912004 3699 17118334 SGTC_1563 conessine 56.1 µM -0.774747577921691 0.211814364501236 no 2662 0.219244415536028 3851 441082 An anti-amoebic, histamine inhibitor. SGTC_1309 pyrazolanthrone 13.4 µM -0.775002443455325 0.21173860066075 no 2663 0.219169107871844 3792 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_340 k038-0059 454 µM -0.775245451038265 0.2116663766033 no 2664 0.21909731784623 3797 23733424 SGTC_2572 astragaloside iv 100 µM -0.778809136517238 0.210608874293791 no 2665 0.21804607744047 3860 45006101 An anti-inflammatory agent. SGTC_206 4546-0025 72.014 µM -0.77888971391246 0.210584999330296 no 2666 0.218022341831541 3822 6620745 YIL048W NEO1 SGTC_2102 5377816 72.7585 µM -0.780376642540938 0.210144709705502 no 2667 0.217584606075027 3815 1379702 SGTC_477 mead ethanolamide 10 µM -0.783630483757185 0.209183113786983 no 2668 0.216628481704636 3670 16061185 SGTC_1514 1189-1591 158 µM -0.78436832996919 0.208965421626882 no 2669 0.21641200794421 3827 767698 YMR146C TIF34 SGTC_2362 9071156 126 µM -0.784845400264985 0.208824739151797 no 2670 0.216272108858348 3812 653133 SGTC_3044 9093193 49.47 µM -0.785261708850368 0.208702020207008 no 2671 0.216150070708525 3788 25236277 SGTC_81 0411-0046 9.971 µM -0.786302152464202 0.20839550540944 no 2672 0.215845245879297 3736 12925265 SGTC_2661 dactinomycin 12.96 µM -0.786715464415334 0.208273817389753 no 2673 0.215724224641562 3803 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3002 9075603 71.4286 µM -0.787536595804444 0.20803218287905 no 2674 0.215483907158661 3785 20105405 SGTC_1970 st070122 35.8 µM -0.788234682990201 0.207826886819236 no 2675 0.215279722745488 3813 102928 SGTC_2333 9017922 200 µM -0.788268466328857 0.207816954726376 no 2676 0.215269844262699 3852 3163164 SGTC_2892 9047358 58.44 µM -0.790480384239336 0.207167274766049 no 2677 0.214623636769395 3809 6466771 SGTC_25 0118-0223 35.662 µM -0.790528268062279 0.207153223726263 no 2678 0.214609660083563 3824 5333628 SGTC_602 3130-1533 38.1 µM -0.790812274458012 0.207069896413275 no 2679 0.214526773062817 3854 720941 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.793807464065121 0.206192317509988 no 2680 0.213653763351707 3779 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3178 9107506 49.47 µM -0.794255291344316 0.20606129559526 no 2681 0.213523412956811 3844 8897194 SGTC_1848 st056003 16.4 µM -0.794807997032267 0.205899657236657 no 2682 0.213362599209666 3857 146492 SGTC_1140 3229-1848 2.98 µM -0.795352452376744 0.205740505248218 no 2683 0.213204255015551 3849 2849525 SGTC_304 1310-0298 97 µM -0.795670809215903 0.205647478880107 no 2684 0.213111698912766 3749 1550234 SGTC_2302 7771753 200 µM -0.795909433702032 0.205577767304804 no 2685 0.213042338822367 3836 2203047 SGTC_3176 9106582 49.47 µM -0.796359699952096 0.205446265083097 no 2686 0.212911497486302 3734 17018027 SGTC_1728 st035614 33.7865 µM -0.796830453706646 0.205308832824244 no 2687 0.2127747529142 3829 15945546 SGTC_1579 chlormadinone acetate 49.4 µM -0.79710242408257 0.2052294584528 no 2688 0.212695774319576 3857 45114258 A steroidal progestin. SGTC_873 0591-4978 488 µM -0.797787327709443 0.205029650576687 no 2689 0.212496958188671 3854 3305145 SGTC_2199 6590217 200 µM -0.797857679303235 0.205009133360232 no 2690 0.212476542441328 3749 703109 SGTC_1959 st077091 55.8 µM -0.798057354566812 0.204950907061848 no 2691 0.212418603731101 3829 821356 YKL052C ASK1 SGTC_2608 thymoquinone 42.66 µM -0.799923122090731 0.204407315286162 no 2692 0.211877670149154 3799 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_738 1315-0003 72.4 µM -0.800140286420655 0.204344100218512 no 2693 0.211814761072898 3840 6251474 SGTC_1763 st044482 94.5 µM -0.800367363540006 0.204278012054417 no 2694 0.211748992108167 3872 88505 SGTC_2553 4-methylesculetin 85.09 µM -0.800653204846494 0.204194839350323 no 2695 0.211666220103824 3882 5319502 SGTC_2834 9001755 58.44 µM -0.800930789574349 0.204114088410469 no 2696 0.211585857112248 3784 2989575 SGTC_1861 st057647 17.4 µM -0.801156349420367 0.204048485808093 no 2697 0.211520568894837 3900 688668 SGTC_3346 9158254 43.5805 µM -0.801278622082613 0.204012928856746 no 2698 0.211485182046888 3854 17639500 SGTC_1965 Pectolinarigenin 58.4 µM -0.802793918619388 0.203572586294593 no 2699 0.211046928868678 3823 5320438 An anti-inflammatory. SGTC_1033 k072-0102 21.3 µM -0.803002924780303 0.203511893979686 no 2700 0.210986522033849 3784 5965931 SGTC_1981 st071826 47 µM -0.803521939035239 0.20336122655994 no 2701 0.210836560691306 3861 11838600 SGTC_1265 0819-1001 68.8 µM -0.804759745477955 0.203002165869712 no 2702 0.210479167593104 3801 3106768 SGTC_2920 7982904 15.77 µM -0.807574514068846 0.20218707338934 no 2703 0.209667781539848 3855 6456808 SGTC_1945 st075991 56.6 µM -0.808074410006644 0.202042520000441 no 2704 0.2095238739675 3850 1084980 SGTC_984 1492-0255 2.91 µM -0.80823799360432 0.201995230463526 no 2705 0.209476794950464 3822 1585198 SGTC_2970 9090938 41.86 µM -0.810826812970017 0.201247724426507 no 2706 0.208732567112356 3867 17217104 SGTC_3205 9113483 49.47 µM -0.81166644060716 0.20100564361961 no 2707 0.20849152795078 3917 17018033 SGTC_2310 7668677 200 µM -0.812006382036534 0.200907681663519 no 2708 0.208393984724911 3822 2197143 SGTC_2724 maprotiline 69.64 µM -0.813184872195162 0.200568294427788 no 2709 0.208056035726401 3790 4011 A tricyclic antidepressant. SGTC_1916 st067606 49.2 µM -0.816516822550303 0.199610607766356 no 2710 0.207102303007443 3861 19590279 SGTC_1895 st058434 18.3 µM -0.817011525448371 0.199468652642905 no 2711 0.206960920790426 3872 5393175 SGTC_964 1287-0107 19.4 µM -0.818335691225419 0.199088982073865 no 2712 0.206582765733277 3880 51516812 YPR165W RHO1 SGTC_2620 irigenin 100 µM -0.819024304291088 0.198891712140034 no 2713 0.2063862735765 3891 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2862 9027634 71.43 µM -0.819131410320749 0.198861039608078 no 2714 0.206355721383295 3793 5012562 SGTC_1134 3477-0009 42.5 µM -0.819403160740402 0.198783229768948 no 2715 0.206278216100939 3928 3973534 SGTC_1312 1218-2183 165 µM -0.819707696511336 0.198696054369172 no 2716 0.2061913806925 3843 6744073 SGTC_3280 9140961 49.47 µM -0.820676333265811 0.198418928936793 no 2717 0.205915327476538 3896 4901226 SGTC_429 1112-0049 25.5 µM -0.821387267855427 0.198215680159046 no 2718 0.205712856757448 3844 2836170 SGTC_938 3126-1755 342 µM -0.821904747769206 0.198067817116871 no 2719 0.205565555318458 3898 1777771 SGTC_1672 st016598 6.51 µM -0.822053934741055 0.198025201284628 no 2720 0.205523100652993 3898 4665860 YNL267W PIK1 SGTC_2007 4011539 71.82 µM -0.822277917312578 0.197961230200126 no 2721 0.205459370914606 3854 45595301 SGTC_135 0933-0004 26.348 µM -0.823551952403223 0.197597593803737 no 2722 0.205097093111509 3859 21230617 YGL099W LSG1 SGTC_596 1155-0152 116 µM -0.824612221723357 0.197295278705124 no 2723 0.204795890237095 3855 280313 SGTC_2533 agelasine 13.65 µM -0.825671341877996 0.196993570762254 no 2724 0.204495276621362 3914 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2640 pentamidine 10.38 µM -0.828518784557516 0.196183815293094 no 2725 0.203688380608707 3883 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_22 0964-0034 14.468 µM -0.829557805253209 0.19588884203362 no 2726 0.203394420781668 3903 138402 SGTC_1995 st072814 61.1 µM -0.830696420362061 0.195565903602745 no 2727 0.203072574538956 3863 5769371 SGTC_487 nimodipine 119 µM -0.831453628528433 0.195351320376166 no 2728 0.202858707006634 3766 4497 L-type voltage-gated calcium channels inhibitor SGTC_989 1501-0895 10.3 µM -0.831933582244788 0.195215381652616 no 2729 0.202723217524835 3817 2830112 SGTC_1177 0983-0204 23.6 µM -0.832741876596163 0.19498657599594 no 2730 0.202495160729801 3926 766818 SGTC_1278 0874-0585 172 µM -0.834984888435472 0.194352496252398 no 2731 0.201863108428832 3938 766306 SGTC_1498 4478-3555 97.6 µM -0.838647947275688 0.193319684765741 no 2732 0.200833448081813 3830 3437919 SGTC_1176 0848-0131 83.3 µM -0.839013922005652 0.193216681336362 no 2733 0.200730748598706 3943 6769040 SGTC_2463 5473429 200 µM -0.839906181606788 0.192965695686077 no 2734 0.200480495702691 3886 5399405 SGTC_584 0986-0246 15.4 µM -0.840301991750575 0.192854421169117 no 2735 0.200369542480804 3985 53315 YDR232W HEM1 SGTC_1815 st051655 58.2 µM -0.841346101789786 0.192561077558256 no 2736 0.20007703534008 3833 5984156 SGTC_2873 9040596 71.43 µM -0.841874050014405 0.192412853927704 no 2737 0.199929228553772 3861 6463863 SGTC_1893 st059353 36.1 µM -0.844739093290592 0.191609698448932 no 2738 0.19912826366227 3933 3112488 SGTC_1411 3909-8223 150 µM -0.845797148488547 0.191313614561754 no 2739 0.198832958243564 3898 X1411 SGTC_1881 5652484 16 µM -0.847191437341387 0.190923868296752 no 2740 0.198444212726706 3850 2255129 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.847430478695082 0.190857097890445 no 2741 0.198377611026801 4011 16725076 SGTC_634 1611-4317 11.2 µM -0.848002940697646 0.190697252757182 no 2742 0.198218166508326 3893 2843522 SGTC_1665 st014639 11.4 µM -0.848759764606558 0.190486055511482 no 2743 0.198007491519273 3943 981133 YIL048W NEO1 SGTC_2989 9073649 71.4286 µM -0.848863410661554 0.190457143507205 no 2744 0.197978650383649 3820 21367202 SGTC_3316 9136639 10.545 µM -0.848961186185371 0.190429871554235 no 2745 0.197951445140992 3930 4903665 SGTC_2837 9008476 45.46 µM -0.848987980345064 0.190422398435194 no 2746 0.197943990278618 3890 2992805 SGTC_296 1222-0039 74.9 µM -0.849177524562087 0.190369538084372 no 2747 0.197891258776577 3891 5984176 SGTC_2519 cryptotanshinone 88.04 µM -0.849509077399016 0.19027709584763 no 2748 0.197799040657696 3861 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1845 st056753 3.01 µM -0.849630590142572 0.190243223056468 no 2749 0.197765249601499 3861 5375839 SGTC_1247 0448-0043 5.84 µM -0.850154768449309 0.190097146010763 no 2750 0.197619522662907 3955 3089013 YGL099W LSG1 SGTC_1282 0886-0010 32.4 µM -0.851811343376099 0.189635948082319 no 2751 0.197159404741629 3971 2836211 YNL267W PIK1 SGTC_836 0330-0104 1.35 µM -0.854065612919016 0.189009455996709 no 2752 0.196534317856017 3889 46494820 SGTC_1444 4112-3581 28 µM -0.854141839519823 0.188988293898678 no 2753 0.196513201975831 3937 2877249 SGTC_607 4491-0986 66.8 µM -0.854960800800403 0.188761025214662 no 2754 0.196286424492713 3924 698981 YDR232W HEM1 SGTC_2309 7664088 163.95 µM -0.855232242094924 0.188685735141392 no 2755 0.196211295065303 3914 704922 SGTC_2863 9028737 58.44 µM -0.855731122346383 0.188547408272219 no 2756 0.196073260641814 3889 6460917 SGTC_943 3253-1379 105 µM -0.855836937672728 0.188518076399889 no 2757 0.196043990332037 3876 668464 SGTC_2840 9008771 71.43 µM -0.856872909594237 0.188231054964505 no 2758 0.195757562990464 3875 2992978 SGTC_2706 st078239 82.5 µM -0.857735479361771 0.187992281335253 no 2759 0.195519272076892 3881 15434492 SGTC_2241 6772625 37.8075 µM -0.858172498893083 0.187871378474142 no 2760 0.195398609644828 3811 2285411 SGTC_1209 2323-2347 50.3 µM -0.859120415835461 0.187609299268269 no 2761 0.195137042381263 3884 5412760 SGTC_3231 9132313 49.47 µM -0.859662794769369 0.187459444489707 no 2762 0.194987474642072 3900 4905967 SGTC_3262 9137218 49.47 µM -0.859708734017649 0.187446755257611 no 2763 0.194974809525419 3725 17650664 SGTC_2499 avocadenofuran 51.48 µM -0.861201011253584 0.187034850674363 no 2764 0.194563671606539 3906 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2014 4013930 200 µM -0.86445226796949 0.186139366069845 no 2765 0.193669745308023 3864 64556 SGTC_2345 9052315 157.45 µM -0.864481905186095 0.186131215414944 no 2766 0.193661608152422 3972 6469265 SGTC_2850 9015429 58.44 µM -0.86536402518131 0.185888721191127 no 2767 0.193419509890069 3987 6457570 SGTC_2361 9034121 116 µM -0.86727403652667 0.185364332041413 no 2768 0.192895939459948 3930 6496917 SGTC_2929 9013348 24.6 µM -0.867937343433838 0.185182437740566 no 2769 0.192714317127356 3957 2995952 SGTC_506 n9-isopropylolomoucine 153 µM -0.868422483839643 0.185049471085491 no 2770 0.192581545358742 3907 6610355 SGTC_1067 clotrimazole 1.36 µM -0.86851639742089 0.185023738226526 no 2771 0.192555849832694 3936 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1880 MG-132 525 µM -0.870022467144574 0.184611370252697 no 2772 0.192144063141562 3864 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_281 1672-3440 14.9 µM -0.870770215549776 0.18440684619542 no 2773 0.191939815511542 3974 6833000 SGTC_2880 9042983 58.44 µM -0.873234066630806 0.183733931914392 no 2774 0.191267754972659 3954 6464714 SGTC_3036 9090181 49.47 µM -0.875233609679467 0.183188953063801 no 2775 0.190723404667235 3962 25236586 SGTC_582 0987-0078 156 µM -0.876444173310758 0.182859502383164 no 2776 0.190394306557641 3970 1625765 SGTC_715 0868-0130 184 µM -0.879789339879221 0.181951051343229 no 2777 0.18948672030257 3973 2876258 SGTC_871 0574-0004 149 µM -0.881570350881376 0.181468533336373 no 2778 0.18900459723764 3924 9551173 SGTC_1179 1021-1431 9.29 µM -0.882336360853874 0.181261249687119 no 2779 0.188797469480117 3985 2840958 SGTC_886 0866-0150 153 µM -0.884577886692649 0.180655541085142 no 2780 0.188192168835988 4013 271463 SGTC_3264 9137442 49.47 µM -0.884869325173894 0.180576881466643 no 2781 0.188113556983895 3910 17015726 SGTC_2997 9067075 71.4286 µM -0.884907005377227 0.180566713099937 no 2782 0.188103394704364 3972 27209819 SGTC_661 1304-0007 33.6 µM -0.886738752009136 0.180072831697453 no 2783 0.18760978477688 3948 3117130 SGTC_1694 st024011 44.9 µM -0.887798779976248 0.179787411338583 no 2784 0.187324499658343 3969 2787533 SGTC_2123 5259487 200 µM -0.889240894308289 0.179399567999122 no 2785 0.18693681460187 3976 2173474 SGTC_1015 4130-4525 82 µM -0.890135480682025 0.179159241815685 no 2786 0.186696571728611 3958 1363237 SGTC_1713 st033146 12.748 µM -0.891323432108705 0.178840417744697 no 2787 0.186377840697374 3922 674619 SGTC_479 n-linoleoylglycine 10 µM -0.891946198476423 0.178673421604197 no 2788 0.186210885319505 3979 6433346 An anti-infammatory. SGTC_644 1498-1197 63.3 µM -0.892117896796429 0.178627397603 no 2789 0.186164871587999 4005 6741615 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.893029092898531 0.178383275028526 no 2790 0.185920796510589 3855 17037758 SGTC_1156 4092-0367 4.88 µM -0.893576815640526 0.178236633409904 no 2791 0.185774177773265 3961 1357585 SGTC_2938 9059746 27.26 µM -0.89361319651593 0.17822689586233 no 2792 0.18576444159481 3985 6471769 SGTC_2141 5621638 7.665 µM -0.895403886558562 0.17774802196276 no 2793 0.185285611896705 3997 2856238 SGTC_2153 5569715 200 µM -0.896327044635381 0.177501464534827 no 2794 0.185039059513815 3979 2054701 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.897281568483733 0.177246757040907 no 2795 0.184784344556557 3944 2724278 An inhibitor of dopamine biosynthesis. SGTC_994 3910-0338 138 µM -0.898858234802986 0.176826541324801 no 2796 0.184364088306208 4065 3479481 SGTC_2564 betulinic acid 100 µM -0.899041257811484 0.176777802554473 no 2797 0.184315342556031 4032 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_355 1311-2252 105 µM -0.901817615834516 0.176039504047728 no 2798 0.183576880216471 3980 5338538 SGTC_163 TUB2.036 7.546 µM -0.902844649779334 0.175766887075672 no 2799 0.183304175118584 3963 15992207 YJR013W GPI14 SGTC_2044 5102272 200 µM -0.904868372345805 0.17523049118872 no 2800 0.182767562159331 4000 592666 SGTC_1849 st056239 19.2 µM -0.905464299473716 0.175072736346709 no 2801 0.18260973242719 3986 5393181 SGTC_1452 4194-0072 190 µM -0.908992787982967 0.174140515776566 no 2802 0.181676966363688 4037 1343545 SGTC_2491 paeonol 100 µM -0.909876025009655 0.173907660705838 no 2803 0.181443947458297 3838 11092 Increases levels of cortical cytochrome oxidase. SGTC_1482 3346-2049 8.48 µM -0.909944882079578 0.1738895156714 no 2804 0.181425789192809 3976 3826804 SGTC_86 0417-1630 471.922 µM -0.910522687693062 0.173737301294158 no 2805 0.18127346117675 3992 3634867 SGTC_1729 st035615 45.989 µM -0.91315175164413 0.173045783778634 no 2806 0.180581367712568 4017 17385451 SGTC_2976 9009005 19.48 µM -0.913664920130468 0.172911010883018 no 2807 0.180446471148106 4011 2993148 SGTC_1900 st060200 72.8 µM -0.915135100541272 0.172525269372503 no 2808 0.180060355024235 3965 688945 SGTC_3118 9124250 49.47 µM -0.915437979114903 0.172445869229665 no 2809 0.179980873967017 3943 1504786 SGTC_3292 9120825 59.784 µM -0.91676724683187 0.172097675058387 no 2810 0.179632309590734 3980 24824900 SGTC_1432 4049-0298 68.4 µM -0.9175264776109 0.171899000334872 no 2811 0.179433412398874 4008 741646 SGTC_718 1130-0073 349 µM -0.917988097968681 0.171778275618574 no 2812 0.179312548505707 4036 6740020 SGTC_658 3253-0951 102 µM -0.919066884295971 0.171496358506545 no 2813 0.179030294611367 4003 1184878 SGTC_2625 euphol 100 µM -0.919442467779597 0.171398277441214 no 2814 0.178932092505556 4031 6708538 A triterpene alcohol. SGTC_383 2324-0395 7.37 µM -0.921471354773207 0.17086906757965 no 2815 0.17840219499025 4006 3146421 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.921635230202568 0.170826368401569 no 2816 0.17835943778208 4000 7104 SGTC_2876 9059903 25.97 µM -0.922022362069281 0.170725524924911 no 2817 0.178258455742306 3932 6916095 SGTC_1428 4049-0204 61.7 µM -0.92367274407668 0.170296046632793 no 2818 0.177828363498317 4058 X1428 SGTC_547 1120-0019 610 nM -0.92719899544329 0.169380733033991 no 2819 0.176911612159117 3940 3676939 SGTC_3344 9148862 3.898 µM -0.927203887677782 0.16937946534774 no 2820 0.176910342359177 4051 4905352 SGTC_2384 9036245 200 µM -0.928398665018654 0.169070054433281 no 2821 0.176600405382523 3953 6462766 SGTC_1212 0520-0165 585 µM -0.92888711142989 0.16894366629757 no 2822 0.17647379653115 4146 5403258 SGTC_3283 9109332 35.8195 µM -0.932113939431693 0.168110232615805 no 2823 0.175638822448536 3849 17027281 SGTC_512 prima-1 270 µM -0.93344836754976 0.167766347560814 no 2824 0.175294258665476 4029 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2532 xanthone 78.9 µM -0.934071325510644 0.167605965122156 no 2825 0.175133551031325 4029 7020 An insecticide. SGTC_2171 5739187 198.077 µM -0.93441276567223 0.167518102216931 no 2826 0.175045507637229 3947 2262761 SGTC_2787 5284540 71.43 µM -0.937670973749503 0.1666811594741 no 2827 0.174206762513288 4073 736958 SGTC_1830 st055982 50.3 µM -0.941508028017308 0.165698993512157 no 2828 0.17322228858724 3924 455313 An antimicrobial agent. SGTC_1618 st003135 44.5 µM -0.94238777201856 0.165474334951544 no 2829 0.172997072687288 3914 1270615 SGTC_1783 st039459 87.517 µM -0.943987978348591 0.165066198693263 no 2830 0.172587895768309 4133 729761 SGTC_399 oxolinic acid 75 µM -0.94408873749342 0.165040521672898 no 2831 0.172562152061013 3984 4628 A DNA gyrase inhibitor. SGTC_2032 5185112 25.99 µM -0.945756748307254 0.164615828865887 no 2832 0.172136335338283 3904 5718189 SGTC_2175 5807670 165.306 µM -0.945969783502497 0.164561638944159 no 2833 0.172081999164138 4022 241186 SGTC_472 calcifediol 10 µM -0.94640957272998 0.164449806001172 no 2834 0.17196986235947 4058 5283731 A vitamin D metabolite. SGTC_869 0564-0080 44.1 µM -0.948253645574212 0.163981417654765 no 2835 0.171500171482319 4055 6843321 SGTC_3111 9122088 49.47 µM -0.949977723498071 0.163544291306797 no 2836 0.171061785915429 3885 16876704 SGTC_1120 ficusin 1.78878 µM -0.950881613831122 0.163315419675289 no 2837 0.170832238129358 4101 6199 A DNA cross-linker. SGTC_606 k015-0008 38.6 µM -0.950921558681107 0.163305310151001 no 2838 0.170822098470992 4121 1970475 SGTC_2715 st079500 56.4 µM -0.952572901449669 0.162887732521697 no 2839 0.17040325633039 3986 28246688 SGTC_2441 5730946 39.09 µM -0.953799852324665 0.162577921501584 no 2840 0.170092482089901 4091 1774275 SGTC_2405 ticlatone 3.52 µM -0.95533656457703 0.162190435388871 no 2841 0.169703761138366 3898 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1795 st049545 62.3 µM -0.956218669496885 0.161968282151537 no 2842 0.169480884808494 3952 5291882 SGTC_1091 telmisartan 47.6 µM -0.958579517186662 0.161374691371161 no 2843 0.168885307644097 4090 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1622 st003707 19.4 µM -0.95945674438226 0.161154491065746 no 2844 0.168664350316421 4072 10140899 SGTC_2045 5106652 78.05 µM -0.960224013917757 0.160962052973867 no 2845 0.16847124169362 4002 673349 SGTC_538 2922-0838 53.3 µM -0.962621828818008 0.16036162666174 no 2846 0.167868669443618 4015 777039 SGTC_1108 betulinic acid 729.144 nM -0.963925861575536 0.160035704765253 no 2847 0.16754154846285 4051 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3325 9138760 55.175 µM -0.964260560828465 0.159952122003896 no 2848 0.167457654304671 3980 43844959 SGTC_1379 2144-0755 36.5 µM -0.964788585533019 0.159820319108222 no 2849 0.167325357130533 4120 5392327 SGTC_3248 9135562 49.47 µM -0.966425736716414 0.159412113366093 no 2850 0.166915595422228 4036 17650701 SGTC_1501 4491-0275 38.4 µM -0.966545098799196 0.159382378457919 no 2851 0.166885745685461 3981 5104718 SGTC_852 0418-0143 439 µM -0.967169440627584 0.159226904602941 no 2852 0.166729668135943 4071 5369229 SGTC_60 0986-0278 202 µM -0.968119680766213 0.15899046611786 no 2853 0.166492300962661 4008 3110598 SGTC_1302 1159-0335 255 µM -0.969011174377264 0.158768854192227 no 2854 0.166269806938896 4051 649284 SGTC_2860 9025725 38.96 µM -0.969167774239937 0.158729946736886 no 2855 0.166230743452897 4073 40546248 SGTC_2283 7944793 200 µM -0.969320799650043 0.158691933398116 no 2856 0.166192577332954 4088 2970533 SGTC_1130 3454-2858 15.9 µM -0.969385532946275 0.158675854671127 no 2857 0.166176433883185 4098 715628 YIL048W NEO1 SGTC_1293 1000-1278 195 µM -0.970181188551435 0.158478313653926 no 2858 0.165978092834467 4110 678847 SGTC_2406 ethylparaben 405.7 µM -0.97020057064146 0.158473503588139 no 2859 0.165973263176068 4086 8434 A possible steroid mimic. SGTC_15 0266-0086 27.098 µM -0.971293841533289 0.158202340883902 no 2860 0.165700987329333 4108 1712902 YIL048W NEO1 SGTC_1492 4158-0558 28.5 µM -0.972417050108368 0.157924070074424 no 2861 0.16542155654306 4039 3967268 SGTC_2268 7933382 153.85 µM -0.974577345881852 0.157389768772374 no 2862 0.164884977714274 4073 935025 YOR257W CDC31 SGTC_2529 gangaleoidin 93.61 µM -0.977274506553596 0.156724355593815 no 2863 0.164216635298106 4094 4565183 SGTC_431 k089-0097 107 µM -0.977475328974979 0.15667488511388 no 2864 0.164166942916008 3892 5499420 SGTC_1872 amphotericin b 148 nM -0.978350581023723 0.156459396058848 no 2865 0.163950480595687 4079 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.981006150799892 0.155806783645737 no 2866 0.163294854191916 4052 66535 A nucleotide analog. SGTC_366 0181-0206 4.31 µM -0.981114161571181 0.155780277788819 no 2867 0.163268223805558 4092 274874 SGTC_3324 9138759 60.749 µM -0.981368963796447 0.155717761071384 no 2868 0.163205412717359 4110 45595710 SGTC_3210 9128157 49.47 µM -0.981583537006085 0.15566512753411 no 2869 0.163152530631734 4113 17590849 SGTC_72 0744-0168 198.391 µM -0.98194162198816 0.155577317540793 no 2870 0.16306430452414 3968 677577 SGTC_1116 jasmonic acid  1.58368 µM -0.981972010085309 0.155569867242517 no 2871 0.163056818836647 4133 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2896 9052656 71.43 µM -0.98668886873509 0.154416280837555 no 2872 0.161897594311544 3920 6469436 SGTC_268 camptothecin 39.6153 µM -0.986756792134347 0.15439971044965 no 2873 0.161880940633701 4041 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2916 7875993 68.79 µM -0.987965220853122 0.154105102336818 no 2874 0.161584840761981 3920 1299250 SGTC_1807 st050092 58.9 µM -0.990280387088114 0.153541717195141 no 2875 0.161018545122537 4102 5008496 SGTC_699 0375-0592 111 µM -0.990740025171771 0.153430028850026 no 2876 0.160906270749188 4154 762578 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.991593752650155 0.153222722801975 no 2877 0.160697869022286 4169 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1934 st074720 32.6 µM -0.992959326005215 0.152891514037433 no 2878 0.160364888245777 4023 17250992 SGTC_2776 terbinafine 19.92 µM -0.994448456349927 0.152530879020182 no 2879 0.160002293676425 4115 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_684 1140-0066 328 µM -0.996177983449849 0.152112734169224 no 2880 0.159581837372161 4151 6813534 SGTC_3117 9124945 49.47 µM -1.00002285797917 0.1511858948889 no 2881 0.15864972303289 3996 17592065 SGTC_1437 4092-1038 11.6 µM -1.00071930793195 0.151018412526348 no 2882 0.158481265068305 4111 3977136 SGTC_2158 5657123 3.6195 µM -1.00102755386632 0.150944324941289 no 2883 0.158406743722365 4025 2858827 SGTC_823 0417-1665 178 µM -1.00194131577616 0.150724842434343 no 2884 0.158185968304668 4075 3429856 SGTC_3032 9089427 49.47 µM -1.00255357729494 0.15057789825041 no 2885 0.158038151898575 4109 17173707 SGTC_1521 st012942 49.4 µM -1.00333747406941 0.150389900538536 no 2886 0.157849030533986 4086 24207259 SGTC_2978 9011784 42.97 µM -1.00612556289807 0.149722516052368 no 2887 0.157177586686341 4085 2994934 SGTC_192 3455-0609 60.9 µM -1.00808927202315 0.149253650886914 no 2888 0.156705803670089 4167 3769639 SGTC_1448 4255-0083 152 µM -1.00929901194281 0.148965295790596 no 2889 0.156415626924496 4177 5399660 SGTC_3293 9120939 62.045 µM -1.01189139113202 0.148348627228644 no 2890 0.155794992958772 4105 934087 SGTC_2074 5212007 75.395 µM -1.01330738761211 0.148012515671177 no 2891 0.155456679961074 3973 758611 SGTC_2926 9010726 65.15 µM -1.01459679509177 0.147706895950014 no 2892 0.155149033853584 4147 2994293 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.01616510953748 0.147335738768088 no 2893 0.15477538407008 4073 442882 SGTC_2644 guaiazulene 100 µM -1.01918492267263 0.14662283184607 no 2894 0.154057591596096 4112 3515 A coloring agent. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.0211053237752 0.146170676399189 no 2895 0.153602270540132 4091 688803 SGTC_987 1497-1013 404 µM -1.0229173619213 0.14574489447753 no 2896 0.153173459901907 4088 1676435 SGTC_3253 9135987 49.47 µM -1.02424573795712 0.145433290726897 no 2897 0.152859610165444 4125 4182430 SGTC_1483 3453-0561 55.9 µM -1.02724132956715 0.144732245621345 no 2898 0.152153420668058 4113 4546991 SGTC_2591 skatole 100 µM -1.02900468455983 0.14432064134371 no 2899 0.151738736771625 4146 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_641 4092-0595 30 µM -1.02954881904407 0.14419378832087 no 2900 0.151610925775283 4156 786260 SGTC_670 4204-0025 119 µM -1.0313000390121 0.143786040177182 no 2901 0.151200070028696 4127 719039 SGTC_1145 3546-0597 10.2 µM -1.03167309496823 0.1436992796998 no 2902 0.151112642725882 4104 875334 SGTC_552 k242-0005 476 µM -1.0318503473265 0.143658069046323 no 2903 0.151071114646403 4190 4088318 SGTC_2414 st077232 92.9 µM -1.03235339501304 0.143541155376667 no 2904 0.150953298031911 4066 729801 SGTC_1653 st012112 65 µM -1.03292963549018 0.143407309862779 no 2905 0.150818414418085 4115 720429 SGTC_2655 perillic acid 100 µM -1.03318136275868 0.143348866690417 no 2906 0.150759516492638 4143 5702197 An apoptosis inducer. SGTC_481 bay k-8644 50 µM -1.03434766661101 0.143078297436036 no 2907 0.1504868302441 4091 2303 A calcium channel antagonist. SGTC_1029 k015-0030 64.7 µM -1.03566819342138 0.142772366938721 no 2908 0.150178482927455 4180 2208316 SGTC_1784 st039334 36.3 µM -1.03581871669484 0.14273752284617 no 2909 0.150143362008743 4189 3496984 SGTC_1780 st038448 24.544 µM -1.03760008532453 0.142325596815336 no 2910 0.149728139091277 4186 728868 YDL195W SEC31 SGTC_3354 9151612 71.43 µM -1.04044602905076 0.141669167390722 no 2911 0.149066363149259 4152 27261949 SGTC_2549 cedrol 20.94 µM -1.04065289742684 0.14162153237552 no 2912 0.149018335705096 4091 6708665 A sedative which affects the nervous system. SGTC_428 3448-4153 16.5 µM -1.04097093607895 0.141548319651317 no 2913 0.148944518660093 4104 3834874 SGTC_750 4073-0104 132 µM -1.04349256436852 0.140968746779215 no 2914 0.148360111403157 3889 22330957 SGTC_1928 4'-methoxychalcone 40.3 µM -1.04390477921714 0.140874156309065 no 2915 0.148264723411269 4177 641818 SGTC_1800 st050079 29.0735 µM -1.04390773559524 0.140873478067913 no 2916 0.148264039443009 3998 3645560 SGTC_6 0844-0013 19.835 µM -1.04436731057445 0.140768071041568 no 2917 0.148157740856491 4257 1584900 SGTC_456 gingerol 170 µM -1.04443127637239 0.140753404241785 no 2918 0.148142949765223 4190 442793 A herb. SGTC_2845 9003024 42.97 µM -1.04465229115779 0.140702735459773 no 2919 0.148091851155009 4210 2990173 SGTC_580 1123-0028 41 µM -1.04503263587003 0.140615568451008 no 2920 0.148003943089384 4177 1677248 YPR107C YTH1 SGTC_202 3594-0513 34.79 µM -1.04538324070804 0.140535249667989 no 2921 0.147922939665679 4154 708429 SGTC_2807 7945238 51.95 µM -1.04680586724932 0.140209664948931 no 2922 0.147594561894899 4175 17148797 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.04899939839156 0.139708654446581 no 2923 0.147089197652914 4212 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1257 0669-0121 16 µM -1.04925920036666 0.139649395448317 no 2924 0.14702941921474 4163 4307855 SGTC_287 k060-0039 29.6 µM -1.04954978202556 0.139583136072298 no 2925 0.14696257791102 4193 5861974 SGTC_1198 1612-1005 86.7 µM -1.0508931883818 0.139277086104276 no 2926 0.146653824599077 4216 6998509 SGTC_2932 9016711 44.54 µM -1.0513208516565 0.139179753293329 no 2927 0.146555626718893 4163 7117328 SGTC_1642 st009582 77.7 µM -1.0524847595416 0.138915091450907 no 2928 0.146288599604509 4139 6739311 SGTC_3153 9100258 49.47 µM -1.05558001830509 0.138212926593667 no 2929 0.145580066940428 4094 25236848 SGTC_2122 5258151 111.688 µM -1.06074942928735 0.137045640073112 no 2930 0.144401894968601 4152 2173356 SGTC_43 0570-0105 72.5 µM -1.06122503626259 0.136938584315705 no 2931 0.144293822031272 4144 1114046 YDL195W SEC31 SGTC_2138 5575593 77.673 µM -1.06128168716753 0.136925836408988 no 2932 0.144280952789835 4144 762213 SGTC_979 1426-2828 121 µM -1.06333794062563 0.136463675560565 no 2933 0.143814362608975 4258 747872 SGTC_1646 st011709 75.6 µM -1.06576232413003 0.135920146340065 no 2934 0.143265548078255 4108 5757843 SGTC_3173 9105693 49.47 µM -1.06766646287819 0.135494292846591 no 2935 0.142835495802164 4173 17096658 SGTC_1077 5-fluorocytosine 377 nM -1.06831809712977 0.135348767492446 no 2936 0.142688523939956 4217 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1913 st060213 96.1 µM -1.06864158543193 0.135276564702911 no 2937 0.142615601250251 4203 688959 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.07101681683633 0.134747220301983 no 2938 0.142080934109673 4134 689007 SGTC_2150 5556613 200 µM -1.07108336422564 0.13473241003861 no 2939 0.14206597378562 4164 743190 SGTC_153 4077-0274 519.67 µM -1.07199126525838 0.134530466299515 no 2940 0.141861977713095 4169 3121976 SGTC_2629 bisabolol 100 µM -1.07404755767182 0.134073855258196 no 2941 0.14140068351847 4208 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_152 4469-0003 551.229 µM -1.07517862392639 0.133823150198658 no 2942 0.141147381916214 4092 697280 SGTC_274 sirtinol 40.1 µM -1.0757536538995 0.133695816286946 no 2943 0.141018722345736 4227 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2129 girgensonine 121.053 µM -1.07664417908227 0.133498783949862 no 2944 0.140819629595089 4180 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1409 3909-8004 61.9 µM -1.0767777293114 0.133469252645321 no 2945 0.140789788517626 4187 2119279 SGTC_228 caffeine 993.056 µM -1.07859819480456 0.133067150118884 no 2946 0.14038344320162 4190 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_758 0868-0029 16 µM -1.07982424406903 0.132796811981386 no 2947 0.140110226475771 4194 762687 SGTC_2205 7238770 200 µM -1.08476491615312 0.131711251235321 no 2948 0.139012893977259 4242 279867 SGTC_1165 k072-0275 30.3 µM -1.08519513557108 0.131617014402866 no 2949 0.138917619115787 4156 6153523 YGL055W OLE1 SGTC_3064 1327-0027 10 µM -1.08703364070778 0.131214825904833 no 2950 0.138510971356375 4095 16000455 YPR107C YTH1 SGTC_1450 4112-4260 37.6 µM -1.08953442595774 0.130669121797478 no 2951 0.137959141091537 4182 1633175 SGTC_1187 1391-0724 117 µM -1.0910795828958 0.130332733598467 no 2952 0.137618932965468 4226 6997986 SGTC_3305 9127027 53.8275 µM -1.09206082276984 0.130119424165639 no 2953 0.137403183970808 4115 41905295 SGTC_1871 st057448 67.3 µM -1.09564620829029 0.129342060466708 no 2954 0.136616815795111 4243 691747 SGTC_31 0508-1974 57.237 µM -1.09676720298584 0.129099674333176 no 2955 0.136371585291873 4118 6810525 SGTC_2709 st078560 56 µM -1.09823786875789 0.128782158737871 no 2956 0.136050317165058 4191 17250903 SGTC_1951 sophoraflavanone G 9.2 µM -1.09833169648718 0.128761919804506 no 2957 0.136029838017652 4151 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2166 5933061 31.504 µM -1.10211184522199 0.127948364750161 no 2958 0.135206525173286 4339 2877375 SGTC_3061 glucosamine 200 µM -1.10273361100673 0.127814892510508 no 2959 0.135071433041343 4120 91431 and experimental redox chemotherapeutic SGTC_588 3970-1144 52.9 µM -1.10419394608653 0.127501788210722 no 2960 0.13475450760617 4074 1888707 SGTC_1904 st060225 78 µM -1.10577738414595 0.127162893038644 no 2961 0.134411443070953 4130 66595 SGTC_842 0271-0008 11.1 µM -1.10606488546059 0.127101427890133 no 2962 0.13434921799168 4235 1221709 SGTC_2708 st078559 56 µM -1.10815023258561 0.126656218575967 no 2963 0.133898469939286 4138 17250902 SGTC_2614 arthonioic acid 13.39 µM -1.10954799797992 0.126358412545171 no 2964 0.133596925198623 4068 6710684 SGTC_3287 9117173 37.0625 µM -1.1123534133654 0.125762167753138 no 2965 0.132993113312329 4191 2789709 SGTC_1732 st034308 51.822 µM -1.11493425584836 0.12521538795311 no 2966 0.132439297918724 4073 830119 SGTC_2721 ifenprodil 61.44 µM -1.11501527234662 0.125198250632221 no 2967 0.13242193859208 4215 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1374 2889-5571 141 µM -1.11505759252063 0.125189299348752 no 2968 0.13241287131286 4252 2853281 SGTC_1929 genistein trimethyl ether 50.5 µM -1.11515202562856 0.125169327093168 no 2969 0.132392640156089 4193 136420 SGTC_2462 5162487 171.77 µM -1.11878801906328 0.124402019485253 no 2970 0.13161529206988 4160 2259986 SGTC_2861 9024595 19.48 µM -1.1219138391156 0.123745008627544 no 2971 0.130949537949991 4114 16482810 SGTC_261 5-fluorouridine 15.376 µM -1.12275031566455 0.123569603806553 no 2972 0.130771775996787 4248 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2536 dehydroabietamide 32.04 µM -1.12469932642938 0.123161582026231 no 2973 0.130358233619156 4310 3983547 SGTC_1085 doxorubicin 7.67 µM -1.12717892401382 0.122643848960908 no 2974 0.129833419762911 4240 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1493 4348-0038 111 µM -1.12854800978108 0.122358642776216 no 2975 0.129544276593607 4192 800424 SGTC_473 2-arachidonoylglycerol 10 µM -1.12859888312223 0.122348053884901 no 2976 0.129533541034724 4059 5282280 An endocannabinoid. SGTC_266 formosanin C 406 nM -1.13010545709507 0.122034763718841 no 2977 0.129215895277584 4097 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3330 9141424 71.43 µM -1.13078982822675 0.121892635846391 no 2978 0.12907178109839 4296 27261020 SGTC_1322 1348-1070 12 µM -1.13538775829866 0.120940767988903 no 2979 0.128106443283818 4218 6758089 SGTC_1489 4065-0444 182 µM -1.14919338330719 0.118114185193716 no 2980 0.125238124318295 4229 2877968 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.1502364658668 0.117902537344116 no 2981 0.12502324535993 4184 279621 SGTC_974 1326-0144 138 µM -1.15026303688742 0.117897149427897 no 2982 0.125017774994648 4268 5411856 SGTC_2986 9022445 71.43 µM -1.15039197544734 0.117871006494229 no 2983 0.124991231869018 4245 6459286 SGTC_2557 derrustone 83.84 µM -1.15526587054818 0.116885806401182 no 2984 0.12399078380629 4229 629853 An antioxidant. SGTC_798 1287-0182 476 µM -1.15629980970885 0.116677560454641 no 2985 0.123779273080635 4294 1649755 SGTC_1803 st050068 52.4 µM -1.15659347673359 0.116618460905033 no 2986 0.123719244331166 4302 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.1568171757372 0.116573456441998 no 2987 0.123673531488663 4237 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3003 9075612 71.4286 µM -1.15777970338478 0.116379952648139 no 2988 0.123476974102289 4272 6501993 SGTC_2467 5474540 200 µM -1.15851315250609 0.116232655197103 no 2989 0.1233273437206 4210 5413519 SGTC_2358 9037157 4 µM -1.16234336586331 0.115465588683524 no 2990 0.12254800903091 4255 2388925 SGTC_2323 6148992 148.28 µM -1.16259460191505 0.115415400324651 no 2991 0.122497010983759 4224 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2971 9092186 9.93 µM -1.16408986387499 0.115117018886892 no 2992 0.122193797956478 4250 25236400 SGTC_2037 5169046 200 µM -1.16609433921479 0.114717884332178 no 2993 0.121788152566728 4305 5718022 SGTC_495 decylubiquinone 155 µM -1.17153757594333 0.113638988101584 no 2994 0.120691381555887 4292 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_887 0885-0007 9.62 µM -1.17238954537325 0.113470777322103 no 2995 0.1205203474767 4311 5719458 SGTC_790 1575-0012 79.1 µM -1.17415247039525 0.113123273682282 no 2996 0.120166979924556 4323 378741 YLR208W SEC13 SGTC_2670 beta-carotene 100 µM -1.17421417005605 0.113111125358938 no 2997 0.120154625840941 4208 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_251 melphalan 456.522 µM -1.17562614901524 0.11283336886313 no 2998 0.119872150763775 4299 460612 A DNA alkylator. SGTC_61 0978-8327 98.565 µM -1.17773680341592 0.11241908142065 no 2999 0.119450774905315 4181 6150059 YHR072W ERG7 SGTC_71 0417-1750 47.813 µM -1.17961944768019 0.112050466688828 no 3000 0.119075802268952 4258 6811472 SGTC_2388 9080168 200 µM -1.1796710972119 0.112040366095528 no 3001 0.11906552678241 4274 15943073 SGTC_1119 parthenolide 318.541 nM -1.18251104180928 0.111485987484503 no 3002 0.118501493441247 4353 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2583 asiatic acid 100 µM -1.18399421729588 0.111197241993625 no 3003 0.118207675955409 4306 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2043 5101342 149 µM -1.1842997753102 0.111137822355188 no 3004 0.11814720887605 4287 678451 SGTC_3129 9127257 49.47 µM -1.18598370009184 0.110810769682234 no 3005 0.117814368317325 4221 837894 SGTC_2506 ethyl hematommate 54.16 µM -1.18945006501434 0.110139702670626 no 3006 0.117131304885968 4339 3940691 An allergen. SGTC_1798 st045719 60.953 µM -1.1915874198118 0.109727379579953 no 3007 0.116711530086513 4222 3980186 SGTC_3186 9110464 49.47 µM -1.19176106057279 0.109693930787648 no 3008 0.116677474084318 4280 17018021 SGTC_3108 9121785 49.47 µM -1.19303875469427 0.109448030910374 no 3009 0.116427097783276 4097 17140271 SGTC_1317 1273-0028 910 nM -1.19340012741248 0.109378554445453 no 3010 0.116356352558636 4294 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_586 0957-0265 8.15 µM -1.19429139894437 0.109207336610483 no 3011 0.116182000468994 4150 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1971 st069429 63.5 µM -1.1964119409047 0.108800743980056 no 3012 0.11576792190811 4280 1246522 YGL099W LSG1 SGTC_2292 7671323 168.05 µM -1.20000087533378 0.108115083928453 no 3013 0.115069500244185 4334 937504 SGTC_882 0843-0131 351 µM -1.20000721791991 0.108113874947656 no 3014 0.115068268608386 4285 5425421 SGTC_3198 9112019 49.47 µM -1.20151809596651 0.1078261588471 no 3015 0.114775145619483 4326 45595555 SGTC_563 tetrahydrosecaminediol 614 µM -1.20325868482317 0.107495383109717 no 3016 0.114438115817134 4332 334274 A psychoactive constituent of the cannabis plant. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.20588903071431 0.106996909481142 no 3017 0.113930140356047 4264 6312947 SGTC_2753 fluvastatin 17.09 µM -1.20614512206965 0.106948467138211 no 3018 0.113880769657007 4297 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3238 9133470 49.47 µM -1.20898376274558 0.106412568104863 no 3019 0.113334541771884 4297 3534688 SGTC_1497 4476-2978 41.3 µM -1.20916148390424 0.10637908123775 no 3020 0.113300405894263 4331 1528379 SGTC_672 1441-0018 53.7 µM -1.21171901184247 0.105898024982558 no 3021 0.1128099794934 4302 251141 SGTC_2659 sanguinarine 24.21 µM -1.21702938373118 0.104904200177839 no 3022 0.111796518147676 4236 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3251 9135047 49.47 µM -1.22104628406183 0.1041569440724 no 3023 0.111034248016667 4334 17682963 SGTC_2686 alizarin 95.37 µM -1.22154265272688 0.104064874130915 no 3024 0.110940313274442 4281 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1506 4226-2149 212 µM -1.22554774814784 0.103324139224647 no 3025 0.110184455631899 4319 991114 SGTC_1382 3002-2117 298 µM -1.22572655759988 0.103291158243969 no 3026 0.110150796345868 4380 1497314 SGTC_2597 laccaic acid a 100 µM -1.22952129822026 0.102593028745708 no 3027 0.10943820874255 4303 5491415 A textile dye. SGTC_725 1497-0963 19 µM -1.23027054843114 0.10245559343305 no 3028 0.109297904605291 4412 3549977 SGTC_2914 7968218 45.32 µM -1.23475521000252 0.101635767834148 no 3029 0.108460810733534 4279 2977111 SGTC_2440 5628896 157.78 µM -1.23632043954675 0.101350761102073 no 3030 0.10816973821865 4290 5522048 SGTC_1751 st044839 27.194 µM -1.23636634349014 0.101342411423561 no 3031 0.108161210345423 4346 5291326 SGTC_1843 st055809 45.5 µM -1.24016329157983 0.100653501149318 no 3032 0.107457501431078 4376 16413835 SGTC_2561 acetosyringone 100 µM -1.24162393562203 0.100389396778172 no 3033 0.107187673145624 4295 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3160 9100216 49.47 µM -1.24685431291288 0.0994478210678718 no 3034 0.106225460677984 4295 17191039 SGTC_1600 coumarin 106 71.1 µM -1.25329325344021 0.0982975644439737 no 3035 0.105049501402335 4390 100336 A hepatotoxic, DNA x-linker. SGTC_359 0081-0058 15.9 µM -1.26043493599194 0.0970332010429142 no 3036 0.103756252705085 4405 3494159 SGTC_1610 st001799 48.1 µM -1.26136895752443 0.096868728625374 no 3037 0.103587973569728 4287 621897 SGTC_2451 5856223 45.7 µM -1.26493006780303 0.0962435284745986 no 3038 0.102948198867224 4312 2179896 SGTC_2448 5185112 27.17 µM -1.26640044747239 0.0959862507829444 no 3039 0.102684875404247 4343 5718189 SGTC_1684 st024538 14.6195 µM -1.26874705286641 0.0955767048902846 no 3040 0.102265647351878 4288 6732859 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.26881057030364 0.0955656372876847 no 3041 0.102254317102323 4337 616764 SGTC_752 1896-0090 130 µM -1.27086478492788 0.0952082087576188 no 3042 0.101888378126551 4338 772567 SGTC_470 aa-861 153 µM -1.2718369607889 0.0950393960230425 no 3043 0.10171552682692 4296 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.27195403996945 0.0950190807822368 no 3044 0.101694724749703 4397 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2225 6654152 15.4 µM -1.27433790300479 0.0946061351294825 no 3045 0.101271844578217 4263 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2447 5741742 33.78 µM -1.27478468500858 0.0945288885579165 no 3046 0.10119273143549 4401 1776504 SGTC_2289 7946404 165.07 µM -1.27735000941356 0.0940862554898751 no 3047 0.100739352660011 4333 1246120 YPR165W RHO1 SGTC_1216 1165-0504 9.65 µM -1.27832860118105 0.0939178082451939 no 3048 0.100566793624418 4355 6304004 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.27838851576684 0.0939075022455494 no 3049 0.100556235653175 4378 688664 SGTC_1462 k081-0014 26.5 µM -1.28609607907756 0.0925886625404923 no 3050 0.099204766176791 3813 3270634 SGTC_581 0958-0271 211 µM -1.28820545812111 0.0922301264397077 no 3051 0.09883722626032 4365 4591145 SGTC_2522 biochanin a 4.94 µM -1.28954272518886 0.0920033609065068 no 3052 0.0986047363999785 4367 5280373 A possible chelator. SGTC_585 0kpi-0023 191 µM -1.29595559707988 0.0909216405321133 no 3053 0.097495391541347 4291 64601 SGTC_1164 k060-0068 93.7 µM -1.30573840573643 0.0892896993492388 no 3054 0.09582076631797 4385 5963676 SGTC_451 chloral hydrate 100 µM -1.30632502208788 0.0891925387114756 no 3055 0.0957210256907002 4373 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3056 9094900 49.47 µM -1.30667262838068 0.0891350021867957 no 3056 0.0956619592823035 4351 25236784 SGTC_1558 st069300 45.6 µM -1.30720498237402 0.0890469393837325 no 3057 0.095571551927392 4314 24208000 SGTC_3119 9125183 49.47 µM -1.31093774408147 0.0884312784829367 no 3058 0.0949393988303724 4216 22695334 SGTC_2416 tofa 880 nM -1.31310789223615 0.0880748073552405 no 3059 0.0945732974140048 4335 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3182 9108849 49.47 µM -1.3142408990407 0.0878891245106372 no 3060 0.0943825745189187 4381 17133045 SGTC_3282 9108498 15.4605 µM -1.31464325511749 0.0878232546741698 no 3061 0.0943149128422114 4331 16459645 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.31944774807466 0.0870395525638419 no 3062 0.093509733902127 4407 23847180 SGTC_942 3253-1115 227 µM -1.31992866252949 0.0869613949874072 no 3063 0.0934294184204732 4404 46497897 SGTC_1138 3761-0006 1.03 µM -1.3217985193226 0.0866580065165994 no 3064 0.0931176257690666 4410 12061087 SGTC_2273 7815444 169.05 µM -1.32280452013192 0.0864951082699545 no 3065 0.0929501968329956 4327 2824616 SGTC_1027 k015-0025 8.67 µM -1.32368783418148 0.0863522651148617 no 3066 0.0928033702668782 4359 3598955 SGTC_2445 5742597 35.57 µM -1.32521313924722 0.0861060192473535 no 3067 0.0925502343143504 4387 1774255 SGTC_3303 9125618 40.5795 µM -1.32557073557035 0.0860483648429813 no 3068 0.0924909624732579 4400 22695467 SGTC_1467 k284-1082 293 µM -1.33256560263036 0.0849263998535975 no 3069 0.0913371997515767 4359 3334705 SGTC_2090 5301565 104.445 µM -1.33408119312326 0.0846847536723 no 3070 0.0910886243302415 4387 2056344 SGTC_3190 9110366 49.47 µM -1.34165905754971 0.0834842665416557 no 3071 0.0898532839512389 4405 17123768 SGTC_1998 st075797 76.8 µM -1.34454807293097 0.0830299709549776 no 3072 0.0893856110243484 4373 24208315 SGTC_2955 9076254 12.21 µM -1.34577206757666 0.0828380604018391 no 3073 0.0891880181351855 4313 16459619 SGTC_2243 6634756 200 µM -1.34654249472505 0.0827174361146496 no 3074 0.0890638127070566 4439 885676 SGTC_1696 st025591 34.7925 µM -1.34756190446078 0.0825580323254756 no 3075 0.0888996651541516 4398 2787147 SGTC_3101 9120531 49.47 µM -1.35022587215487 0.0821425629084844 no 3076 0.0884717708325669 4397 24824904 SGTC_2369 9071472 200 µM -1.35158397816579 0.0819313612936253 no 3077 0.0882542192810604 4427 17296037 SGTC_2638 epoxomicin 18 µM -1.35291338221511 0.0817250197562988 no 3078 0.0880416518376319 4377 9915668 A protesome inhibitor. SGTC_973 1325-0077 65.9 µM -1.35368600608934 0.0816052781826289 no 3079 0.0879182872858761 4412 2835149 SGTC_1809 st050081 57.6 µM -1.35931627444416 0.0807366880322581 no 3080 0.0870231945845655 4469 5036894 SGTC_2228 7354201 200 µM -1.35945429242671 0.0807154837935515 no 3081 0.087001338457916 4496 753451 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.36179245342812 0.0803569018436076 no 3082 0.0866316969339785 4350 1241132 A phosphatase inhibitor. SGTC_2400 5203494 178.7 µM -1.36489467830971 0.0798830022474206 no 3083 0.0861430775607045 4317 6777674 SGTC_189 3970-0742 2.116 µM -1.36535865212652 0.0798123071183592 no 3084 0.0860701764270412 4382 2891807 SGTC_103 0844-0104 51.839 µM -1.3679521765726 0.0794180062120657 no 3085 0.0856635230297725 4243 5375804 SGTC_227 fluconazole 33.516 µM -1.369664434302 0.0791584959376353 no 3086 0.0853958378538595 4415 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2902 5787006 60.46 µM -1.37224896996436 0.0787679997544522 no 3087 0.0849929727745401 4368 591003 SGTC_115 0527-0192 112.043 µM -1.37992926831058 0.0776162004979217 no 3088 0.083804211968865 4405 4233931 SGTC_2995 9067767 71.4286 µM -1.38084330576585 0.0774799800016991 no 3089 0.0836635724661988 4429 11673567 SGTC_2195 6536160 144.242 µM -1.38111668693026 0.0774392728520425 no 3090 0.0836215428035532 4405 3834386 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.38183568010825 0.0773322904777864 no 3091 0.0835110804100179 4433 6708561 SGTC_2607 solasodine 47.35 µM -1.38352334578226 0.0770816158491915 no 3092 0.0832522270167264 4385 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1968 st069590 43.6 µM -1.38488085583126 0.0768804288449143 no 3093 0.0830444508739373 4385 6384066 SGTC_2739 tacrine 100.86 µM -1.38592520691648 0.0767259247983265 no 3094 0.082884871453936 4478 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2013 4024628 200 µM -1.38721890629884 0.0765348590457335 no 3095 0.0826875110283633 4450 5230760 SGTC_2856 9022925 19.48 µM -1.38755323998962 0.0764855403878731 no 3096 0.082636564277755 4440 4944862 SGTC_315 k915-0449 187 µM -1.38916627150776 0.0762479364684541 no 3097 0.0823910977046153 4462 20970215 YNL149C PGA2 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.39021595168921 0.0760936177167943 no 3098 0.0822316554806556 4461 804 An inhibitor of viral and cellular DNA polymerases. SGTC_895 0964-0006 13.7 µM -1.39241356919159 0.0757713050477201 no 3099 0.081898598904853 4418 6738897 SGTC_1162 k048-0130 20.1 µM -1.39535520313881 0.0753415003961101 no 3100 0.0814543764612508 4405 6797406 SGTC_3076 9116187 49.47 µM -1.39729195077828 0.0750595367290385 no 3101 0.0811628976774938 4435 27241210 SGTC_1235 benzylparaben 21.5 µM -1.39738905698989 0.0750454206228113 no 3102 0.0811483040265141 4465 7180 SGTC_439 amiodarone 34.4 µM -1.39776807706165 0.0749903427211963 no 3103 0.0810913617700154 4305 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_774 k060-0086 136 µM -1.39901179559065 0.0748098263605194 no 3104 0.0809047229498589 4426 5911235 SGTC_2189 6047310 154.431 µM -1.40190478503008 0.0743912134556636 no 3105 0.0804718407024188 4419 711535 SGTC_1907 st060210 83.7 µM -1.40628685186133 0.073760541873634 no 3106 0.079819481403733 4429 688793 SGTC_259 usnic acid 108.925 µM -1.40845484458384 0.0734500371258852 no 3107 0.0794982144810546 4482 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1010 4112-3296 15.2 µM -1.41277114545669 0.0728348244447484 no 3108 0.0788615124612645 4474 704384 SGTC_2743 auranofin 4.32 µM -1.41674931647481 0.0722713070176634 no 3109 0.0782781163912086 4484 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2208 7283366 200 µM -1.41894709191073 0.0719614229659835 no 3110 0.0779572207813401 4443 898663 SGTC_100 0086-0128 49.5915 µM -1.42194326727026 0.0715406078466612 no 3111 0.0775213606171892 4455 93297 SGTC_815 1582-0027 36.9 µM -1.4247432183218 0.071149061811493 no 3112 0.0771157206349648 4462 3128206 SGTC_1772 st048439 82.2 µM -1.42592542925161 0.0709842359597568 no 3113 0.0769449341426796 4489 2927068 YDL195W SEC31 SGTC_139 0099-0334 718.624 µM -1.42733241425926 0.0707884541314934 no 3114 0.0767420508474237 4462 97690 SGTC_1570 verbenone 133 µM -1.43427386438125 0.0698286194728446 no 3115 0.0757470627841031 4472 29025 A natural terpanoid with antifungal properties. SGTC_2076 5212012 200 µM -1.44004232814149 0.069038627332915 no 3116 0.0749277119793854 4430 604802 SGTC_1630 st005209 31.3 µM -1.44584800225661 0.0682505120841145 no 3117 0.0741099194886356 4458 3367314 SGTC_1874 staurosporine 7.6 µM -1.45452258582254 0.0670859060639097 no 3118 0.0729007381482759 4466 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1720 st037298 9.481 µM -1.45999603213676 0.0663590144125797 no 3119 0.0721455822175073 4460 597396 SGTC_3240 9133527 49.47 µM -1.46456748391883 0.0657565972356308 no 3120 0.0715194794029894 4442 17617455 SGTC_1086 cerivastatin 2.18 µM -1.46560887497573 0.0656199593803086 no 3121 0.0713774360256826 4484 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.46633782875769 0.0655244465508937 no 3122 0.0712781372850208 4498 5106787 A p450 inhibitor. SGTC_1605 st000082 49.1 µM -1.46877758601081 0.0652055559167868 no 3123 0.0709465627030639 4430 1114022 SGTC_558 k064-0027 21.3 µM -1.47121345922829 0.0648883755701449 no 3124 0.0706166992079732 4480 5088526 SGTC_3252 9135871 49.47 µM -1.47172914630232 0.0648213807209882 no 3125 0.0705470168119455 4494 17682838 SGTC_3149 9097855 49.47 µM -1.47297067804817 0.0646603089564498 no 3126 0.0703794712065812 4466 25236625 YMR079W SEC14 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.47355320498521 0.064584841275374 no 3127 0.0703009643051372 4448 756377 SGTC_3091 9116372 49.47 µM -1.4748149015966 0.0644216202158663 no 3128 0.0701311569067175 4526 17169793 SGTC_1367 1812-0510 76.9 µM -1.47692312298693 0.064149602783151 no 3129 0.0698481229320449 4537 1142582 YDR527W RBA50 SGTC_3004 9076122 71.4286 µM -1.47733012272637 0.0640971918090206 no 3130 0.0697935835803681 4488 44782551 SGTC_298 1391-0729 10 µM -1.47832595459269 0.063969094956416 no 3131 0.0696602769329276 4424 3237558 SGTC_2648 atorvastatin 78.68 µM -1.48355280882437 0.0633000107951241 no 3132 0.0689637983872914 4476 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1224 0823-0416 294 µM -1.48404464209322 0.0632373332399098 no 3133 0.068898538868026 4508 3598164 SGTC_518 1021-0119 62.6 µM -1.48601525826421 0.0629866891956311 no 3134 0.0686375425668884 4458 1097762 SGTC_1059 3448-6867 171 µM -1.48857892033638 0.0626617742629247 no 3135 0.0682991429501978 4463 3934407 SGTC_2719 novobiocin 32.65 µM -1.48896924310462 0.06261242009643 no 3136 0.0682477340481505 4519 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2550 chrysin dimethyl ether 71.87 µM -1.50355074717638 0.0607902892264452 no 3137 0.0663485405223427 4348 88881 An O-methylated flavonoid and antioxidant. SGTC_666 0272-0154 136 µM -1.50832661007287 0.0602025892038232 no 3138 0.0657354779736635 4499 6870312 SGTC_1201 1889-3372 45.9 µM -1.51118902476692 0.0598524885565839 no 3139 0.0653701489376097 4409 5392199 SGTC_1851 st056236 18.9 µM -1.51885540008802 0.0589226713877706 no 3140 0.0643994487144081 4479 5393171 SGTC_2765 myclobutanil 7.74 µM -1.5197007413896 0.0588208416728706 no 3141 0.0642931025972832 4515 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_968 1309-0633 340 µM -1.5233231749972 0.0583860468228368 no 3142 0.0638389359421146 4537 3761976 SGTC_587 k089-0003 57 µM -1.52457287974741 0.0582366337684289 no 3143 0.0636828330491136 4425 9659696 SGTC_2782 7736369 71.43 µM -1.52847300328471 0.0577722710239584 no 3144 0.0631975706992386 4495 2950836 YOL077C BRX1 SGTC_1011 4112-3381 17.4 µM -1.53040943293267 0.0575427968163129 no 3145 0.0629577077716775 4550 2877139 SGTC_282 k297-0036 65.7 µM -1.5372312802617 0.0567400898022871 no 3146 0.0621183414485365 4521 5061378 SGTC_700 3453-2283 142 µM -1.53792209652003 0.0566592977206093 no 3147 0.0620338319159996 4546 565664 SGTC_1222 0366-0074 1.18 µM -1.54133533008486 0.0562614438726429 no 3148 0.0616175972404682 4529 286520 SGTC_2669 eugenol 100 µM -1.54246170901753 0.0561306351419125 no 3149 0.0614807179700744 4542 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_946 3434-1334 87.4 µM -1.54552961006153 0.0557755694131137 no 3150 0.0611091062228789 4490 4047976 SGTC_796 1234-0020 70.7 µM -1.54737750330588 0.0555625588952133 no 3151 0.0608861213698281 4464 46495034 SGTC_2389 9091542 195.52 µM -1.54814551449401 0.0554742177654606 no 3152 0.060793632995119 4481 3626624 YOL127W RPL25 SGTC_1686 st019653 115.5 µM -1.55599460094979 0.054577715097738 no 3153 0.0598546881116874 4516 97252 SGTC_12 0849-0099 9.267 µM -1.56011058508547 0.0541121983633763 no 3154 0.0593668752872452 4474 6071388 SGTC_561 1550-0330 72.9 µM -1.56163263018849 0.0539408534684975 no 3155 0.0591872789629304 4490 6812934 SGTC_3217 9129673 49.47 µM -1.56477725987149 0.0535882060513584 no 3156 0.0588175727667337 4501 17248312 SGTC_3052 9092717 49.47 µM -1.56793527520488 0.0532358981189691 no 3157 0.0584481191722161 4530 25237534 SGTC_262 fenpropimorph 62.5 µM -1.57337554420543 0.0526332905827791 no 3158 0.0578159431604091 4561 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1109 tnp00067 928.257 nM -1.57497450619909 0.0524572099024952 no 3159 0.0576311646137435 4539 676295 SGTC_2163 5671233 125 µM -1.5751171875793 0.0524415203151117 no 3160 0.0576146987266469 4486 701023 SGTC_3026 9090633 49.47 µM -1.57798053577008 0.0521274465047984 no 3161 0.0572850407334463 4543 25236842 SGTC_652 0437-0092 114 µM -1.5787386421502 0.0520445422798596 no 3162 0.0571980087457771 4500 3091274 SGTC_808 0711-0032 135 µM -1.58307355002124 0.0515724999281761 no 3163 0.0567023507149354 4509 4252555 SGTC_705 1124-0212 310 µM -1.58588928865447 0.0512677130293901 no 3164 0.0563822130264499 4532 9554485 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.60258800264602 0.0494895188284121 no 3165 0.0545128221225653 4555 140250 A respiratory chain inhibitor. SGTC_1638 st008370 60.6 µM -1.60373818015481 0.0493688750891713 no 3166 0.0543858881348651 4495 24207134 SGTC_849 0386-0493 241 µM -1.609284358295 0.0487904209046617 no 3167 0.0537770888633076 4578 726119 SGTC_1828 st055811 49 µM -1.61023407767092 0.0486919126475396 no 3168 0.0536733822689585 4547 5877589 SGTC_676 falcarinol 140 µM -1.61121893330666 0.0485899279129909 no 3169 0.0535660062724161 4564 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2515 chrysin 20.77 µM -1.61159077753636 0.0485514667762938 no 3170 0.0535255094423461 4553 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.61209259922162 0.0484996002170109 no 3171 0.0534708954829152 4585 1273210 SGTC_2375 9072683 200 µM -1.61470159037372 0.0482306574708905 no 3172 0.0531876664928782 4587 16798029 SGTC_1124 fisetin 1.16336 µM -1.61562672396152 0.048135578930972 no 3173 0.053087521201712 4557 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3219 9131112 49.47 µM -1.61597960067969 0.0480993523512025 no 3174 0.0530493618712416 4417 17612988 YMR079W SEC14 SGTC_1554 st069299 38.7 µM -1.61616904272869 0.0480799130953249 no 3175 0.053028884989492 4502 24207999 SGTC_1511 0906-3109 28.5 µM -1.62316164705735 0.0473667680435715 no 3176 0.0522774270759348 4554 2882180 SGTC_1035 k081-0041 55.2 µM -1.62336631906412 0.0473460228188905 no 3177 0.0522555601072027 4567 731709 SGTC_1921 5740136 50 µM -1.63728780145596 0.0459519695120387 no 3178 0.0507851742762407 4497 1774243 SGTC_110 0850-0284 111.64 µM -1.64096428058735 0.0455893764405117 no 3179 0.0504024150486283 4503 3906265 SGTC_1200 1643-0193 18.4 µM -1.64248375723351 0.0454401913334477 no 3180 0.0502448948027028 4586 5403974 SGTC_2186 6124449 200 µM -1.64368524891196 0.045322504771401 no 3181 0.0501206172545272 4585 3834182 YLR033W RSC58 SGTC_2455 5377712 9.75 µM -1.64659390648915 0.0450386157586987 no 3182 0.0498207718890551 4563 2243908 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.64736641374937 0.0449634589931891 no 3183 0.049741377230568 4565 803109 SGTC_1115 galangin 695.678 nM -1.65015126846435 0.0446933597316312 no 3184 0.0494560005059844 4630 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2985 9022375 71.43 µM -1.65023216937111 0.0446855328373044 no 3185 0.0494477297977445 4574 4939335 SGTC_1762 st045503 25.4615 µM -1.66056994851165 0.0436944350042198 no 3186 0.0483999243302202 4602 4645554 SGTC_387 norethindrone acetate 66.7 µM -1.66190915603898 0.0435673510355807 no 3187 0.048265495287857 4584 541197 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.66579930976176 0.0431998864035381 no 3188 0.0478766968397983 4596 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3208 9114115 49.47 µM -1.68121355826464 0.041768393269738 no 3189 0.0463607204556741 4534 650895 SGTC_1183 1254-0324 198 µM -1.68906774025186 0.0410539020136336 no 3190 0.0456032245762374 4618 5799357 SGTC_2104 5389443 200 µM -1.69630879851779 0.0404039983949052 no 3191 0.044913707545506 4592 2244536 SGTC_2413 inermin 26.06 µM -1.69638151297204 0.0403975147010409 no 3192 0.0449068262412313 4612 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1442 4112-3290 3 µM -1.70783321429048 0.039386902431547 no 3193 0.0438336471032355 4600 704353 SGTC_1940 st075990 51.1 µM -1.71200008919838 0.0390243189920458 no 3194 0.043448326011236 4621 1084979 SGTC_2789 5281112 71.43 µM -1.71359765073524 0.0388860287762595 no 3195 0.0433013226585091 4598 765948 SGTC_155 k072-0202 43.6 µM -1.7138975402981 0.0388601138867345 no 3196 0.0432737724433158 4585 5857737 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.71940889306575 0.0383863511371414 no 3197 0.0427699720316479 4596 641818 YHR062C RPP1 SGTC_2027 5150920 200 µM -1.72010011919912 0.0383272661880421 no 3198 0.0427071220432418 4556 786715 SGTC_297 0986-0032 24 µM -1.74007015541018 0.036652027944278 no 3199 0.0409233499853895 4587 2847425 SGTC_3189 9110682 49.47 µM -1.74016794805401 0.0366439741596641 no 3200 0.0409147659539467 4597 17122418 SGTC_185 k048-0037 25.491 µM -1.74456696447093 0.0362831844973297 no 3201 0.0405301377416799 4652 6827589 SGTC_3024 9090631 49.47 µM -1.75004116694731 0.0358382786703367 no 3202 0.0400556052179153 4608 25236383 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.75787653714003 0.0352092602487106 no 3203 0.0393842594187853 4618 5393153 SGTC_475 α-linolenic acid 10 µM -1.76788224894939 0.0344192053115125 no 3204 0.0385402954761682 4611 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1314 1222-0010 41.1 µM -1.77201365606277 0.0340972648546303 no 3205 0.0381961451902593 4626 3526027 SGTC_2075 5212009 200 µM -1.77640213558631 0.0337580080320819 no 3206 0.0378333296840946 4571 780898 SGTC_2485 5633444 17.78 µM -1.78593459326628 0.0330306534113856 no 3207 0.0370549245135769 4592 5724239 SGTC_1286 0929-0070 131 µM -1.78701800034392 0.0329488097016349 no 3208 0.0369672896547624 4661 1420408 SGTC_692 k241-0027 77.8 µM -1.78836330467094 0.0328474142088904 no 3209 0.0368587062885941 4645 3600480 SGTC_3314 9135860 59.4275 µM -1.78936883667192 0.0327717954239922 no 3210 0.0367777173419054 4610 25252478 SGTC_160 3453-0671 289.699 µM -1.7955273575987 0.0323117831408054 no 3211 0.0362848590010213 4609 5322268 SGTC_1405 3909-7894 12 µM -1.80315116601075 0.0317497154442345 no 3212 0.0356822387021141 4619 7104060 SGTC_2857 9024691 58.44 µM -1.81196700878372 0.0311098611367358 no 3213 0.0349956471489232 4633 16478292 SGTC_1562 morin hydrate 59.1 µM -1.81203937532759 0.0311046532453039 no 3214 0.0349900563188172 4628 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3265 9137266 49.47 µM -1.81364155568379 0.0309895362375971 no 3215 0.0348664641556961 4615 17224265 SGTC_2143 5623677 140.463 µM -1.8161070540765 0.0308130785110195 no 3216 0.0346769759221951 4613 5375313 SGTC_1652 st011932 78 µM -1.83953312344207 0.0291775976752739 no 3217 0.0329184053028169 4592 1551076 SGTC_2160 5660466 132.927 µM -1.84092054379428 0.0290830415064922 no 3218 0.0328166016792159 4601 2859134 SGTC_3136 9095672 49.47 µM -1.84300182167989 0.0289416747544398 no 3219 0.0326643722551957 4509 17217380 SGTC_3138 9097216 49.47 µM -1.84701524921648 0.0286706828613892 no 3220 0.0323724651161194 4591 25237486 SGTC_2325 6158266 200 µM -1.85304680302161 0.0282673954418954 no 3221 0.0319378253014332 4607 3623240 SGTC_2066 5222451 176 µM -1.85638942784438 0.0280459385231502 no 3222 0.0316990352759589 4586 2281147 SGTC_2257 7960413 200 µM -1.86661876878894 0.0273771786365309 no 3223 0.0309774223410138 4676 2974689 YIL048W NEO1 SGTC_2749 bexarotene 57.39 µM -1.86872853420725 0.027240916584323 no 3224 0.0308302960209193 4639 82146 An retinoic acid receptor inhibitor. SGTC_1251 0490-5699 265 µM -1.87065717441313 0.0271168481892192 no 3225 0.0306963071630971 4655 3883818 SGTC_2324 6149169 200 µM -1.87505125543258 0.0268359394232284 no 3226 0.0303928362643501 4630 2888231 SGTC_2594 a-mangostin 100 µM -1.87600256109155 0.0267754445303851 no 3227 0.0303274641102966 4637 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_161 4065-0411 162.148 µM -1.87852074222409 0.0266158592556498 no 3228 0.0301549811196924 4640 1906281 YLR208W SEC13 SGTC_1620 st003704 16.5 µM -1.87876778397815 0.0266002463078194 no 3229 0.0301381038672365 4667 2834414 SGTC_1475 4092-1048 11.7 µM -1.87966261437709 0.0265437573897443 no 3230 0.0300770369131164 4654 2881759 SGTC_2291 7917025 104.35 µM -1.87974089049626 0.0265388207399296 no 3231 0.0300716999078004 4558 2964612 SGTC_1324 1418-0026 34.4 µM -1.87992905244982 0.0265269570445916 no 3232 0.0300588739027095 4675 1372513 SGTC_1719 st032227 49.2 µM -1.88454274749775 0.0262374450011332 no 3233 0.0297457991231702 4643 3125804 SGTC_1330 1469-0054 61.8 µM -1.88981105006093 0.0259100912045804 no 3234 0.0293916175852328 4619 7102664 SGTC_1804 st050076 49.1 µM -1.90772828052853 0.0248222445149886 no 3235 0.0282131722704192 4681 3895976 SGTC_1545 lovastatin 49.4 µM -1.90998768408471 0.0246878244019202 no 3236 0.0280673995389588 4682 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2859 9028643 45.46 µM -1.91434131147657 0.0244305331675952 no 3237 0.0277882795684651 4525 17151580 SGTC_753 1322-0200 289 µM -1.91759920852948 0.0242394732945881 no 3238 0.0275809252901429 4703 5403907 SGTC_3073 9114972 49.47 µM -1.92346241310892 0.023898785973195 no 3239 0.02721100127885 4667 41905075 SGTC_3086 9117350 49.47 µM -1.92938462566459 0.0235587645525388 no 3240 0.0268415654551167 4665 2679265 SGTC_1794 st048918 76.9 µM -1.93162384982223 0.02343126497043 no 3241 0.0267029749668501 4658 672303 SGTC_805 3852-0218 479 µM -1.9332242799632 0.0233404939868798 no 3242 0.0266042874872283 4658 6615355 SGTC_2828 7998861 71.43 µM -1.94056808787874 0.0229277637888233 no 3243 0.0261553440014464 4681 2988188 SGTC_1628 st004252 77.7 µM -1.94519944891942 0.0226706505789515 no 3244 0.0258754890766675 4654 692968 SGTC_98 0074-0023 107.663 µM -1.94726223596533 0.0225569182282751 no 3245 0.0257516518522026 4673 3563821 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.95571879022748 0.0220956796160051 no 3246 0.0252491449902815 4648 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1573 oleylamine 1.06 µM -1.95912400698452 0.021912212983562 no 3247 0.025049132974436 4657 5356789 An amine of the fatty acid oleic acid. SGTC_529 4076-0302 30.3 µM -1.98209589120197 0.0207078436281482 no 3248 0.0237342546680701 4673 5816522 SGTC_3039 9090270 49.47 µM -1.98614333613008 0.0205015612670796 no 3249 0.0235087052621964 4664 17173750 SGTC_2193 5925765 200 µM -1.99521929832265 0.020045317384811 no 3250 0.0230094835737142 4697 877370 SGTC_3194 9111903 49.47 µM -2.00226654244962 0.0196970226944167 no 3251 0.0226280361796578 4658 17087251 SGTC_2306 7482397 179.52 µM -2.01661812998873 0.0190035915050172 no 3252 0.0218676897705185 4668 891448 SGTC_2912 7964298 10.93 µM -2.03306995949219 0.0182343296041011 no 3253 0.0210227277419099 4668 2975850 SGTC_3007 9078383 71.4286 µM -2.03885135275504 0.0179703767910351 no 3254 0.0207324326593011 4689 6496995 SGTC_314 1671-0008 2.74 µM -2.06027533782259 0.0170204742495395 no 3255 0.0196861131104103 4581 3913060 SGTC_1812 st052057 4.327 µM -2.06731360149232 0.0167179256314817 no 3256 0.0193523067156763 4729 3645418 SGTC_3093 9117344 49.47 µM -2.0736088212089 0.0164512273738526 no 3257 0.0190578276461176 4714 24824913 SGTC_696 1560-0013 611 µM -2.07741303016738 0.016291833521868 no 3258 0.0188817272942795 4704 1650269 SGTC_2252 omeprazole 400 µM -2.08102839025184 0.0161415800153787 no 3259 0.0187156537656525 4735 4594 A proton pump inhibitor. SGTC_1550 gossypolone 36.6 µM -2.0915263202459 0.0157120004048344 no 3260 0.0182404547801572 4725 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1106 tegaserod maleate 11.7 µM -2.11654145974233 0.0147277188266935 no 3261 0.0171493914749078 4724 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_521 r062-0005 13.8 µM -2.12362805640619 0.0144587088013827 no 3262 0.0168506287865317 4652 2832033 SGTC_2639 lactacystin 53 µM -2.12399682984659 0.0144448265579009 no 3263 0.0168352043303624 4702 3870 A proteasome inhibitor. SGTC_2764 methyldopa 94.69 µM -2.12448545164782 0.0144264503740307 no 3264 0.0168147856524209 4683 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1229 0139-0193 12.2 µM -2.13978644922279 0.0138611037329461 no 3265 0.0161860144086817 4748 3090752 SGTC_1129 3453-1384 223 µM -2.15076310034387 0.0134673980862155 no 3266 0.0157474514883244 4674 1084452 SGTC_1007 4101-0031 70 µM -2.15545883210259 0.0133019448338006 no 3267 0.0155629734118986 4710 1146276 SGTC_2745 rifampicin 24.3 µM -2.16268483710005 0.0130507681308903 no 3268 0.0152827140567462 4778 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_420 mitomycin C 81.9 mM -2.1743947975954 0.0126524325672872 no 3269 0.0148377492316515 4711 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1464 k208-0027 110 µM -2.17814475107859 0.0125271154745898 no 3270 0.0146976308981425 4713 X1464 SGTC_1602 st001878 87.6 µM -2.18467137706176 0.0123115685062358 no 3271 0.0144564751552922 4699 595405 YLR310C CDC25 SGTC_26 0302-0163 425.158 µM -2.19797613176088 0.011882101223559 no 3272 0.0139754034395564 4750 3100915 SGTC_1034 k072-0165 12.7 µM -2.21005516178606 0.0115035159097024 no 3273 0.0135506670973211 4731 5835461 SGTC_7 0192-1582 4.227 µM -2.21085352080319 0.0114788667448665 no 3274 0.0135229910930779 4738 252616 SGTC_2689 tacrolimus 100 µM -2.22386640180034 0.0110835173747766 no 3275 0.0130787170910057 4704 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_341 1486-1430 230 µM -2.23722708084728 0.0106899758542977 no 3276 0.0126357511323901 4713 2054753 YPL210C SRP72 SGTC_686 1319-0111 510 µM -2.24477621084438 0.0104730397991421 no 3277 0.01239125134667 4728 4562600 SGTC_2398 5228213 48.84 µM -2.24578853878142 0.010444242694068 no 3278 0.0123587778907777 4688 80771 YMR134W ERG29 SGTC_742 0kpi-0133 140 µM -2.25585857472879 0.010161523330757 no 3279 0.0120397447902067 4747 2728852 SGTC_2835 9006588 71.43 µM -2.26174952976319 0.00999924730480874 no 3280 0.0118564413479953 4659 2345538 SGTC_402 epigallocatechin gallate 10 µM -2.2677140963384 0.00983725269332719 no 3281 0.0116733190608569 4728 65064 An antioxidant. SGTC_1455 4262-0120 131 µM -2.27733257887668 0.009580846288577 no 3282 0.0113831864345948 4745 1529587 SGTC_1779 st039427 55 µM -2.2837373040378 0.00941336883845564 no 3283 0.0111934871433874 4715 1124498 SGTC_165 k038-0023 64.381 µM -2.28433539507071 0.00939786083726519 no 3284 0.0111759136189187 4709 46368543 SGTC_403 arphamenine a 50 µM -2.31674082215234 0.00859033650541753 no 3285 0.0102589272014701 4750 5487158 An arginine aminopeptidase inhibitor. SGTC_2676 harmalol 100 µM -2.32022084422125 0.00850734561332498 no 3286 0.0101644667822919 4744 5459187 A monoamine oxidase inhibitor SGTC_1977 st070720 65.3 µM -2.32693060913062 0.00834931647336964 no 3287 0.00998447938499428 4742 682188 SGTC_853 0419-0306 21 µM -2.37374315743287 0.0073167486555885 no 3288 0.00880439726136191 4770 762713 SGTC_2466 5983409 37.09 µM -2.38943870673763 0.00699667218751542 no 3289 0.00843706962016423 4757 2879657 SGTC_739 1486-1183 203 µM -2.40370108119833 0.00671660666862621 no 3290 0.00811501916241489 4753 4346692 SGTC_2088 5278280 127.392 µM -2.4256977972076 0.00630407238432853 no 3291 0.0076394936131726 4771 791502 SGTC_95 0471-0001 561.058 µM -2.42606203702173 0.00629743438849155 no 3292 0.00763183043127818 4745 4015405 SGTC_1529 apigenin 74 µM -2.43150354558271 0.00619900117495109 no 3293 0.007518150577486 4752 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2322 7413319 38.22 µM -2.43883607919157 0.00606851690503907 no 3294 0.00736732517572121 4695 1840400 SGTC_2915 7971052 15.16 µM -2.44156523092439 0.00602057610747211 no 3295 0.00731187308014469 4737 5741558 SGTC_2793 7325131 81.82 µM -2.44954139361512 0.00588238405293887 no 3296 0.00715191338518144 4737 4176441 SGTC_276 colchicine 750 µM -2.50067147555462 0.00506146406980847 no 3297 0.00619790537477585 4778 2833 A microtubule depolymerizer. SGTC_737 1950-0117 57.9 µM -2.50300753426458 0.00502652262784082 no 3298 0.00615714612978895 4765 5393513 SGTC_2647 atorvastatin 60.16 µM -2.50301348006344 0.00502643396871575 no 3299 0.00615704269195006 4764 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_53 0973-0023 39.979 µM -2.54019431946512 0.00449851084749862 no 3300 0.00553954470987223 4724 674768 SGTC_3033 9090887 49.47 µM -2.54238058883393 0.00446906903767817 no 3301 0.00550501073987555 4760 19325384 SGTC_525 k781-2675 26.7 µM -2.54643556379417 0.00441491723354008 no 3302 0.00544146507500792 4735 3651118 YDL195W SEC31 SGTC_2936 9038235 15.59 µM -2.59172013194972 0.00384881476007015 no 3303 0.00477487120057035 4724 4749415 SGTC_806 3966-4455 5.86 µM -2.60292574136002 0.00371918118119869 no 3304 0.00462159859329652 4770 714982 SGTC_811 0416-0114 265 µM -2.62903117602046 0.00343224194445736 no 3305 0.00428142551964908 4771 6612453 SGTC_14 0354-0009 295 µM -2.63630970326173 0.00335586722983558 no 3306 0.00419065981107736 4799 1713507 SGTC_1636 st007707 68.9 µM -2.63674475748046 0.00335135089895381 no 3307 0.00418528945476049 4772 403051 SGTC_445 e6 berbamine 66 µM -2.64431326509246 0.00327365109513218 no 3308 0.00409284294784466 4776 6610268 A calcium/calmodulin antagonist. SGTC_343 4130-2827 29.8 µM -2.67867685267991 0.00294085990722047 no 3309 0.00369568440107848 4770 1118244 SGTC_370 0180-0345 38.7 µM -2.68296512296589 0.00290154556447911 no 3310 0.00364863000213547 4674 3989527 SGTC_520 3584-0023 682 µM -2.76656051405831 0.00222401847411554 no 3311 0.00283255348253874 4760 1340790 SGTC_1365 1672-3266 55.4 µM -2.81798071043155 0.0018820520266168 no 3312 0.00241633565349899 4785 6415873 SGTC_1500 4488-1866 171 µM -2.87640556845719 0.00155198667282791 no 3313 0.00201116264274372 4804 2900003 SGTC_1508 1080-0625 72.9 µM -2.9778101954113 0.00110178387141007 no 3314 0.00145157853640562 4762 767111 SGTC_862 0452-0056 10.2 µM -3.00482621349344 0.00100396164875436 no 3315 0.0013286631647141 4792 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_394 menadione 8.33 µM -3.31168418284801 0.00033201935460295 yes 3316 0.000463680860236327 4799 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_846 0335-0850 148 µM -3.31982336212857 0.000322008168852369 yes 3317 0.000450372104538861 4804 6819598 SGTC_2801 7907800 81.82 µM -3.47096081858984 0.000180208022677949 yes 3318 0.000259299832207427 4790 6620925 SGTC_24 0417-1663 219 µM -3.55460478279459 0.000129424756275037 yes 3319 0.000189273819785973 4805 4329390 SGTC_404 fumagillin 50 µM -3.92796576440414 2.71211169252373e-05 yes 3320 4.28337010605145e-05 4807 12015870 A methionine aminopeptidase binder. SGTC_522 1273-0010 11.6 µM -3.93047107659389 2.68255309531072e-05 yes 3321 4.23897961134749e-05 4805 5705015 SGTC_419 nsc-638432 893 µM -4.12515657703914 1.12285529240184e-05 yes 3322 1.85241311329397e-05 4807 368090 SGTC_459 nigericin 15.3 µM -4.49166675766356 1.96427831130395e-06 yes 3323 3.53339684432255e-06 4810 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_851 0394-0702 453 µM -4.62038249224071 1.03106432272958e-06 yes 3324 1.91516618007934e-06 4806 762646 SGTC_3124 9127567 49.47 µM -4.66662858617661 8.14573532644346e-07 yes 3325 1.53091031080285e-06 4807 17592030 SGTC_443 clozapine 122 µM -5.63683859766704 3.50860326104344e-09 yes 3326 8.6600151895598e-09 4810 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_844 0330-0132 15.3 µM -5.67640190381192 2.7528382250257e-09 yes 3327 6.87786891819245e-09 4809 2828079