SGTCid condition conc unit TIM44|YIL022W.score TIM44|YIL022W.strain.pval TIM44|YIL022W.strain.significant TIM44|YIL022W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2651 TUB2.036 5 µM 12.8394284179156 2.05244041598069e-46 yes 1 4.92998742134216e-38 9 15992207 YFL037W TUB2 SGTC_163 TUB2.036 7.546 µM 10.9245020301269 3.62829937013432e-34 yes 2 4.40109420374333e-28 13 15992207 YJR013W GPI14 SGTC_1658 st012944 20 µM 6.91070730513416 8.21648025223312e-15 yes 3 2.41121572562256e-12 3 24207260 SGTC_1161 k007-0610 110 µM 5.82135143009746 5.00606560537877e-11 yes 4 2.91868409091213e-09 18 5843850 SGTC_2567 aureobasidin a 60 nM 5.75473643813601 8.14207573882668e-11 yes 5 4.33885368247759e-09 20 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_137 0438-0332 85.389 µM 5.36003168669941 1.30236555577302e-09 yes 6 4.1603678068168e-08 23 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_514 4466-0038 2.65 nM 5.16626459987454 4.74263331844519e-09 yes 7 1.19409322077192e-07 26 5722064 SGTC_2688 kanamycin b 96.69 µM 5.14412806960253 5.48146478826824e-09 yes 8 1.34383073080585e-07 3 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_266 formosanin C 406 nM 5.12429645301728 6.23749127076167e-09 yes 9 1.49325390056039e-07 13 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_435 c-PAF 6.7 µM 4.85515101607135 3.43803753343008e-08 yes 10 6.01475162970194e-07 12 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_70 0141-0289 43.283 µM 4.7395263650279 6.96961494299213e-08 yes 11 1.07109180871127e-06 14 352408 SGTC_1116 jasmonic acid  1.58368 µM 4.53022184846012 2.4050123119981e-07 yes 12 2.94608910337564e-06 3 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_373 0844-0104 25.9 µM 4.47052017086542 3.39148433505104e-07 yes 13 3.9014791962984e-06 8 5375804 SGTC_1935 st074532 41.6 µM 4.17135568551251 1.78095258784276e-06 yes 14 1.51396398380022e-05 5 2829742 SGTC_58 0957-0393 9 µM 4.0212022781657 3.93339206227053e-06 yes 15 2.89509282477289e-05 50 6997992 SGTC_235 0330-0087 5 mM 3.80933111661323 1.14979008403294e-05 yes 16 6.96716232974537e-05 4 46494818 YHR062C RPP1 SGTC_1568 digitonin 820 nM 3.7254862545834 1.73228190708366e-05 yes 17 9.74695378359171e-05 18 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1348 1493-0373 93.8 µM 3.59234618037521 3.2650307438872e-05 yes 18 0.000163857049632751 8 3010129 SGTC_1666 st014829 29 µM 3.58249114181324 3.41903116269685e-05 yes 19 0.000170166580376479 8 3858230 SGTC_2340 7987427 183.45 µM 3.54402665512249 4.08838235741802e-05 yes 20 0.000197032701564184 9 2239331 SGTC_309 k408-0051 1.48 µM 3.52699461305181 4.42275995744395e-05 yes 21 0.000210152657373411 35 3640463 SGTC_887 0885-0007 9.62 µM 3.47183547705304 5.69180344573867e-05 yes 22 0.000258456510902459 14 5719458 SGTC_1741 st038134 10.228 µM 3.27849714528156 0.000133983484209711 yes 23 0.000521807098998177 10 1272587 SGTC_318 1488-0629 67.2 µM 3.2642161272156 0.000142482936292915 yes 24 0.00054883698963058 5 3662576 SGTC_2658 polymyxin b sulfate 77.05 µM 3.23520748504392 0.000161325732086052 yes 25 0.000607771822659393 19 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_857 0438-0306 1.35 µM 3.21737990537279 0.000174037323426626 yes 26 0.00064683586903566 7 4686136 SGTC_629 3448-6466 76.7 µM 3.15382375110205 0.000227386052530121 yes 27 0.000805731879077052 10 573744 SGTC_453 enantio-paf c16 10 µM 3.14320260257598 0.000237667888687053 yes 28 0.000835550652781881 31 13871343 A lipid and platelet activating factor SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 3.10006354682191 0.000284050754369127 yes 29 0.000967395637696084 12 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1930 st074634 34.3 µM 3.08086247501223 0.000307295475063141 yes 30 0.00103200978511935 26 684253 YOR116C RPO31 SGTC_3347 9188721 44.724 µM 3.03713611805338 0.000366991614634043 yes 31 0.00119418788385894 18 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_384 k007-0144 5.16 µM 3.00004986735624 0.000425886944247523 yes 32 0.00134967704359716 31 6824886 SGTC_2129 girgensonine 121.053 µM 2.98567731467246 0.000450981417670623 yes 33 0.00141475522380907 39 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1652 st011932 78 µM 2.98297876434765 0.000455843257213492 yes 34 0.00142728899796458 44 1551076 SGTC_249 wiskostatin 11.211 µM 2.96348602409039 0.000492431212869629 yes 35 0.00152087937148644 8 2775510 A n-wasp and actin depolymerizer. SGTC_2630 antimycin a 100 µM 2.94928676921694 0.000520774957319693 yes 36 0.00159254139825021 21 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_940 3232-1287 54.8 µM 2.86558183497836 0.000720895103568457 yes 37 0.00208121836439533 9 1585493 YIL048W NEO1 SGTC_713 1488-1073 324 µM 2.85243204326786 0.000758121531802269 yes 38 0.0021693043998062 12 3312542 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.82387849740095 0.000845128623209657 yes 39 0.002372318381376 24 1377 SGTC_883 0850-0245 24.6 µM 2.80780743342157 0.00089805033254737 yes 40 0.00249400218349495 29 6823229 YPR165W RHO1 SGTC_168 3970-0862 530.542 µM 2.78267501523188 0.000986944491226149 yes 41 0.00269563894584635 77 3135186 SGTC_3001 9076041 71.4286 µM 2.77283448523663 0.00102389920803006 no 42 0.00277851885544975 15 16004211 SGTC_457 grayanotoxin iii 135 µM 2.74384193734197 0.00114028062793957 no 43 0.00303623845227544 34 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2582 agaric acid 100 µM 2.72257118120099 0.00123323977665708 no 44 0.00323880386288922 53 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2586 curcumin 80 µM 2.70718764992273 0.00130473616028929 no 45 0.00339279452741889 31 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1680 diphenhydramine 100 µM 2.65985681681161 0.00154913055501264 no 46 0.00390869383551824 32 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1160 4092-0570 10.5 µM 2.65223852508271 0.00159215721068788 no 47 0.00399800164480932 33 4994975 SGTC_283 0987-0079 11.7 µM 2.64425319185986 0.00163842354870049 no 48 0.00409356946653682 10 411556 SGTC_1154 4088-0362 150 µM 2.62254108780406 0.00177048069071063 no 49 0.00436383716956091 31 6618304 SGTC_3107 9121808 49.47 µM 2.59816890617343 0.0019301998502713 no 50 0.00468611900006809 20 662681 SGTC_20 0481-0013 4.944 µM 2.56548626398397 0.00216492162388687 no 51 0.00515156503565976 40 182045 SGTC_455 paf C-16 10 µM 2.54531935197767 0.0023223751097933 no 52 0.00545889191699905 29 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_695 3505-6186 243 µM 2.54327159015502 0.00233892942759755 no 53 0.00549099157522586 39 1819379 SGTC_104 0074-0074 590.992 µM 2.51946825769394 0.0025393494352805 no 54 0.00587661185440055 43 3943124 SGTC_2253 7938677 135.83 µM 2.51938141726204 0.00254010820350597 no 55 0.00587806159266242 15 2301972 SGTC_462 ag-879 158 µM 2.50275824747885 0.00268918448588739 no 56 0.00616148430621444 41 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3126 9127922 49.47 µM 2.45350193122461 0.00317842524377124 no 57 0.00707363898802787 72 45595682 SGTC_1208 2323-2347 50.3 µM 2.43850688193936 0.00334251726880428 no 58 0.00737403893682398 12 5412760 SGTC_371 0195-0006 7.36 µM 2.42965179160925 0.00344295830990314 no 59 0.00755666746682087 39 3928593 SGTC_683 panaxydol 45 µM 2.42686038392371 0.00347517800930143 no 60 0.00761505781101179 17 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2337 9009472 200 µM 2.42499903401228 0.00349681280209607 no 61 0.00765421374407417 36 5742383 SGTC_3199 9111318 49.47 µM 2.40216318508886 0.00377225672869243 no 62 0.00814921798163346 28 8548020 SGTC_1567 st069303 68.4 µM 2.39802763707609 0.00382417030085676 no 63 0.00824181074571981 46 5581319 SGTC_732 3970-1727 52.7 µM 2.37461562363522 0.00413031802840097 no 64 0.00878361662432613 26 1275699 SGTC_2338 7999974 200 µM 2.34511163019037 0.00454726093169062 no 65 0.00951069182055367 44 315925 SGTC_504 lovastatin 124 µM 2.34313772615631 0.00457645236297952 no 66 0.00956116138886582 41 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2972 9093619 59.92 µM 2.33440625796005 0.004707595523929 no 67 0.009787229710839 30 25236256 SGTC_46 0329-0187a 2.197 µM 2.32991148389826 0.00477640367771664 no 68 0.00990541496987479 37 46494817 SGTC_1974 st069448 26.9 µM 2.32933402579823 0.00478530838142711 no 69 0.00992068857714852 26 6323587 YNR016C ACC1 SGTC_2711 st079103 59.1 µM 2.29592199581175 0.00532642624279789 no 70 0.0108401709197964 22 54693780 SGTC_2217 6934799 96.0675 µM 2.28738111865807 0.00547320161148883 no 71 0.0110867936971923 21 675606 SGTC_3003 9075612 71.4286 µM 2.27267145279169 0.00573442928333936 no 72 0.0115229931001435 32 6501993 SGTC_2139 5578692 56.4705 µM 2.27096759990074 0.00576539189705642 no 73 0.0115744697015117 52 650991 YMR113W FOL3 SGTC_2941 9056145 11.23 µM 2.26689542216105 0.00583999375746337 no 74 0.0116983074759604 39 2119517 SGTC_2439 5492030 7.2 µM 2.26397115995444 0.00589409296741063 no 75 0.0117879443191513 32 5722370 SGTC_1352 1496-0991 99 µM 2.24739118543873 0.00620931066468079 no 76 0.0123075189222646 28 3000039 SGTC_2442 5158906 48.48 µM 2.24723490146806 0.00621235162877731 no 77 0.0123125093827672 28 1893835 SGTC_748 act1.228 77.9 µM 2.23168694792198 0.00652155461661025 no 78 0.0128178302439818 36 4421505 YNR035C ARC35 SGTC_779 1360-0071 233 µM 2.22997234773058 0.00655647269645023 no 79 0.0128746393541394 39 7566 SGTC_649 1123-0311 367 µM 2.20741455728775 0.00703150102240004 no 80 0.0136425551392408 51 693629 YIL048W NEO1 SGTC_1569 carminic acid 40.6 µM 2.20654940373387 0.00705030956444535 no 81 0.0136727775542062 28 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1246 0422-0085 105 µM 2.20189238933577 0.00715231831495123 no 82 0.0138364553618515 53 264295 SGTC_775 4577-0580 57.3 µM 2.19732830785175 0.00725355245441616 no 83 0.0139985036749669 37 2006902 SGTC_874 0599-0792 117 µM 2.16448997221327 0.00801991550272463 no 84 0.01521338268762 49 765305 SGTC_1396 3511-0007 98.6 µM 2.15744706394877 0.00819325899439309 no 85 0.0154854237590787 35 X1396 SGTC_2374 9071832 200 µM 2.14400198087341 0.00853333483742915 no 86 0.0160163640331904 41 17381698 SGTC_2948 9070189 9.45 µM 2.13865612193706 0.00867195500536104 no 87 0.0162317643407098 32 6473636 YDL196W YDL196W SGTC_2497 7-hydroxyflavone 100 µM 2.1345512972876 0.00877973113225936 no 88 0.0163988396339254 43 5281894 SGTC_2758 dehydroepiandrosterone 69.35 µM 2.12914224838048 0.00892354295314473 no 89 0.0166212466280627 48 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_65 0798-0905 34.986 µM 2.12153881069794 0.0091291857672607 no 90 0.0169382427392445 52 3602145 SGTC_1673 st016611 27.3 µM 2.11202573771401 0.00939231101074757 no 91 0.0173421208913934 49 5226799 SGTC_1466 k213-0079 57.5 µM 2.10875671380411 0.00948424917952958 no 92 0.0174827933448166 67 3657981 SGTC_1968 st069590 43.6 µM 2.10831992103805 0.00949659296293063 no 93 0.0175016629689274 64 6384066 SGTC_994 3910-0338 138 µM 2.1023268025427 0.00966738277122126 no 94 0.0177623291391247 69 3479481 SGTC_2955 9076254 12.21 µM 2.09543074826288 0.00986721987726558 no 95 0.0180663592790222 42 16459619 SGTC_1117 retinoic acid 1.10837 µM 2.09488575605156 0.00988316563810681 no 96 0.0180905746830648 38 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2887 9044784 58.44 µM 2.07870611013378 0.0103669223151279 no 97 0.0188221855213701 77 6465546 SGTC_3337 9144342 33.5465 µM 2.07743265050496 0.0104058594194317 no 98 0.018880822651111 54 17682949 SGTC_1555 citronellol 128 µM 2.07578425292657 0.0104564498240675 no 99 0.0189569547093907 33 8842 A terpine precursor. SGTC_3108 9121785 49.47 µM 2.05903741661022 0.0109826927887812 no 100 0.0197453271274316 59 17140271 SGTC_1859 st055998 20 µM 2.05719348928789 0.0110420200440607 no 101 0.0198338087881189 48 676301 SGTC_246 cycloheximide 667 µM 2.05535746074725 0.0111013699396552 no 102 0.0199222455394003 50 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2880 9042983 58.44 µM 2.04995223965299 0.0112777079060195 no 103 0.0201845458435255 63 6464714 SGTC_631 k072-0230 41.5 µM 2.03048040915338 0.0119332846323652 no 104 0.0211538652779989 50 5773147 SGTC_103 0844-0104 51.839 µM 2.02999336062119 0.0119500977051495 no 105 0.0211786070840809 115 5375804 SGTC_3342 9147791 14.508 µM 2.0223242017439 0.0122175609394801 no 106 0.0215714349823043 42 1838168 SGTC_827 3253-0474 693 µM 2.0203898329366 0.0122858360778033 no 107 0.0216714835961789 57 5402065 SGTC_1701 st028638 40.4 µM 2.01225771862476 0.012576494135148 no 108 0.0220963884885015 36 3490878 SGTC_2814 7977482 42.97 µM 2.00689268724169 0.0127714937888828 no 109 0.0223805453364718 67 6456762 SGTC_2050 5263056 171 µM 1.99540186233322 0.0131979621507103 no 110 0.0229995339954044 81 763468 YGL055W OLE1 SGTC_897 1000-0139 31.4 µM 1.98027146989564 0.0137782364115827 no 111 0.0238365164083548 47 6151020 SGTC_1844 rapamycin 4 nM 1.97553011279693 0.0139645459787819 no 112 0.0241040104002175 118 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1755 st041960 45.185 µM 1.96112586654348 0.0145439344866993 no 113 0.0249321710014748 67 2257073 SGTC_3081 9117243 49.47 µM 1.95784833381389 0.0146786205844698 no 114 0.0251239059787142 96 45595589 SGTC_1903 st060211 78.3 µM 1.94822249245973 0.0150804031485118 no 115 0.0256941733015602 54 688960 SGTC_1434 4073-0095 163 µM 1.94375549543051 0.0152700433823002 no 116 0.0259624714504157 44 24133745 SGTC_1153 4055-0057 267 µM 1.94303102455911 0.0153009920407311 no 117 0.0260062049505496 68 882706 SGTC_1913 st060213 96.1 µM 1.93862607209163 0.0154903290209311 no 118 0.0262734432384531 44 688959 SGTC_1440 4100-1550 40 µM 1.93516024081735 0.0156407103308422 no 119 0.0264853175191168 43 742806 SGTC_505 gw-5074 63.9 µM 1.92534380869482 0.0160734582002297 no 120 0.0270931801859312 52 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1184 1269-1718 139 µM 1.92401374320384 0.0161328749534264 no 121 0.0271764304193081 60 5403821 SGTC_2332 7982454 138.89 µM 1.91031227294783 0.0167559811969755 no 122 0.0280465092511431 67 2981748 SGTC_465 cgp-37157 41 µM 1.90993101601671 0.0167736101245902 no 123 0.0280710479800755 35 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1688 st021091 57.6 µM 1.90516177349951 0.0169954789218323 no 124 0.0283795227674126 49 3656366 SGTC_1929 genistein trimethyl ether 50.5 µM 1.9030270744206 0.0170955966801636 no 125 0.028518506257083 51 136420 SGTC_75 0159-0059 199.013 µM 1.89658452830795 0.0174008148307251 no 126 0.0289413970774911 74 5377270 SGTC_421 streptovitacin 30 mM 1.88721732376898 0.0178528847115256 no 127 0.029565550575668 45 91467 include heat shock SGTC_3195 9113082 49.47 µM 1.87974332344825 0.0182207367423192 no 128 0.0300715340373803 40 17018038 SGTC_1365 1672-3266 55.4 µM 1.87357347554451 0.0185292496996617 no 129 0.0304946183831751 69 6415873 SGTC_1009 4106-0057 9.87 µM 1.87012296883377 0.0187037178738165 no 130 0.0307333717777465 67 2928005 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.86762529599959 0.0188308784680615 no 131 0.0309071589781061 65 688798 SGTC_2909 7941780 10.49 µM 1.86716695158749 0.018854293227866 no 132 0.0309391385794005 65 1243215 SGTC_3209 9113616 49.47 µM 1.86220910315762 0.0191091544408105 no 133 0.0312868108988264 73 16649353 SGTC_2725 haloperidol 53.21 µM 1.85190573252276 0.0196481848491879 no 134 0.0320196803164075 80 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2449 5812982 45.77 µM 1.8404448871759 0.020262882887697 no 135 0.0328514742737457 42 776185 SGTC_2211 7117706 200 µM 1.84000996911457 0.0202865270885125 no 136 0.0328833868649509 41 822771 SGTC_25 0118-0223 35.662 µM 1.83967524446654 0.0203047402255238 no 137 0.032907965051323 43 5333628 SGTC_1853 st056710 91.2 µM 1.83121399588852 0.0207697609976048 no 138 0.0335343042554794 65 269167 SGTC_2549 cedrol 20.94 µM 1.82939480039178 0.0208709112203544 no 139 0.0336702429955379 83 6708665 A sedative which affects the nervous system. SGTC_2259 7964009 200 µM 1.82746934070158 0.0209784238502995 no 140 0.0338146159522844 47 313134 SGTC_2871 9038510 12.99 µM 1.82598690109 0.0210615184183464 no 141 0.0339261174767126 86 4945164 SGTC_467 ro 31-8220 72.8 µM 1.82362430716496 0.0211945234438458 no 142 0.0341044446075843 76 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_810 3825-7150 143 µM 1.81747763684577 0.0215438901418179 no 143 0.0345720047521963 41 22330411 YGL099W LSG1 SGTC_2341 7987486 176.74 µM 1.81624351394341 0.0216146192685193 no 144 0.0346665129172859 59 1258686 SGTC_3153 9100258 49.47 µM 1.8063092735166 0.0221911413610791 no 145 0.0354350220569031 60 25236848 SGTC_3131 9127911 49.47 µM 1.80218748060653 0.0224341256105496 no 146 0.0357579568682042 61 45595681 SGTC_2223 6903751 107.57 µM 1.79677804868657 0.0227564190153321 no 147 0.0361854312864726 57 5598863 SGTC_988 1497-1057 103 µM 1.79628364633425 0.0227860690979175 no 148 0.0362247086990677 63 3533044 SGTC_1201 1889-3372 45.9 µM 1.79202366343952 0.023042898178782 no 149 0.0365645877765638 70 5392199 SGTC_1008 4106-0037 6 µM 1.78942769859533 0.0232005979172753 no 150 0.0367729809160756 72 2905394 SGTC_2946 9065502 71.43 µM 1.78758070972957 0.0233133512006378 no 151 0.0369218399961442 42 16489101 SGTC_2246 7293507 91.5585 µM 1.78704201162556 0.0233463238916465 no 152 0.0369653493459658 84 887656 SGTC_2350 9023895 38.85 µM 1.77733643383363 0.023947139531612 no 153 0.0377564512783391 70 2997209 SGTC_1626 st003712 1.76 µM 1.77440529281514 0.0241311242707529 no 154 0.0379980675053281 83 24207035 SGTC_1759 st043059 70 µM 1.77257560129763 0.0242465730075621 no 155 0.0381495288202206 80 669426 SGTC_1713 st033146 12.748 µM 1.76346013122013 0.0248286692843622 no 156 0.0389114579126804 71 674619 SGTC_2741 miltefosine 3.04 µM 1.76087479223501 0.0249958818553322 no 157 0.039129798656009 37 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2415 st077333 57.7 µM 1.7596159563547 0.0250776410336665 no 158 0.0392364721151833 105 2766255 SGTC_989 1501-0895 10.3 µM 1.75560862482558 0.0253394042067304 no 159 0.0395776292671712 55 2830112 SGTC_280 3448-3607 3.04 µM 1.75507263737702 0.0253745884149721 no 160 0.0396234419912129 44 626179 SGTC_3150 9097574 49.47 µM 1.7510649238082 0.0256389687371536 no 161 0.0399673636704786 58 17217476 SGTC_800 3448-7362 155 µM 1.74699346570506 0.0259099116229131 no 162 0.040319235784637 135 15991913 SGTC_1861 st057647 17.4 µM 1.74440716996632 0.0260832626265592 no 163 0.0405440578237213 67 688668 SGTC_2432 5630864 12.22 µM 1.73951683344292 0.0264136974393743 no 164 0.0409719469388238 76 5714970 SGTC_621 3584-0052 32.1 µM 1.73455858324263 0.0267522854711604 no 165 0.0414095103820507 78 2273927 SGTC_250 brefeldin a 552.239 µM 1.73383392362316 0.0268020731551329 no 166 0.0414737773153426 36 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_439 amiodarone 34.4 µM 1.72827962799756 0.0271862554724309 no 167 0.041969051811537 70 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1641 st009299 47.1 µM 1.72730172960894 0.0272543686443204 no 168 0.0420567443660495 82 4046054 SGTC_539 4859-0462 2.54 µM 1.72359422468904 0.0275139002727367 no 169 0.0423905609323064 90 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_673 1082-0474 110 µM 1.72268475995626 0.0275778780998341 no 170 0.042472773887909 132 3098046 SGTC_3014 9081533 49.47 µM 1.7169948959491 0.0279809618856724 no 171 0.0429900522861206 82 21367265 SGTC_568 1193-0097 7.48 µM 1.71652058144355 0.0280147839137091 no 172 0.043033402148729 103 3646150 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.7135252601841 0.0282291590637722 no 173 0.0433079751458317 57 140250 A respiratory chain inhibitor. SGTC_533 1222-0222 6.71 µM 1.71123359054708 0.0283940943735019 no 174 0.0435190000533092 80 3982874 SGTC_1479 0549-0158 134 µM 1.70876572076744 0.0285726070367462 no 175 0.0437471774002386 73 5440202 SGTC_2491 paeonol 100 µM 1.70027131303401 0.0291941984296776 no 176 0.0445399519019927 54 11092 Increases levels of cortical cytochrome oxidase. SGTC_1276 0871-0068 94.2 µM 1.69989706900375 0.0292218406625538 no 177 0.0445751441707719 86 3414906 SGTC_341 1486-1430 230 µM 1.69917499459278 0.029275235614606 no 178 0.0446431081836014 112 2054753 YPL210C SRP72 SGTC_802 4112-3352 742 µM 1.69796614952285 0.0293648069735599 no 179 0.0447570754513972 68 704594 SGTC_694 1315-0438 43.2 µM 1.6962428227109 0.0294928930559662 no 180 0.0449199518749745 58 6793154 SGTC_2256 7954252 200 µM 1.69547575190249 0.0295500544964131 no 181 0.0449926031737763 80 2972920 SGTC_891 0929-0073 133 µM 1.69279895690656 0.029750247715692 no 182 0.0452468706574213 75 5603632 SGTC_1010 4112-3296 15.2 µM 1.69134549893255 0.0298594200677254 no 183 0.0453854174643191 58 704384 SGTC_1043 0916-0009 19.3 µM 1.6867172793536 0.0302092715892987 no 184 0.04582886395258 79 3101130 SGTC_487 nimodipine 119 µM 1.67027696623656 0.0314795874767197 no 185 0.0474322891234739 38 4497 L-type voltage-gated calcium channels inhibitor SGTC_2045 5106652 78.05 µM 1.66942762878892 0.0315463962438434 no 186 0.0475163309613636 58 673349 SGTC_1207 2099-0101 141 µM 1.66622275776163 0.0317995472317531 no 187 0.0478345273985501 79 5837381 SGTC_2967 9089538 49.85 µM 1.66023605385808 0.0322769289933719 no 188 0.0484334871179949 97 728216 SGTC_916 4466-0038 42 nM 1.65304887232585 0.0328578338614367 no 189 0.0491604587613238 111 5722064 YGL116W CDC20 SGTC_2685 mycophenolic acid 18.85 µM 1.64850205517937 0.0332297618790619 no 190 0.0496248446558445 62 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_639 0833-0042 114 µM 1.64425860293869 0.0335799964222268 no 191 0.0500613982201338 97 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_727 3032-0951 202 µM 1.64408987012949 0.0335939854037919 no 192 0.0500788200404536 68 3652836 SGTC_2355 9061122 103.12 µM 1.64302274160251 0.033682568014905 no 193 0.050189114046521 76 5302957 SGTC_180 1486-1293 102.781 µM 1.64047648818126 0.0338947098470341 no 194 0.0504530665925136 90 4140536 SGTC_2699 st077704 54.6 µM 1.63788948920114 0.0341113707393218 no 195 0.0507223744804621 70 645852 SGTC_258 haloperidol 50.781 µM 1.63423978651293 0.0344189681294171 no 196 0.0511042557072961 111 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_912 3474-0017 2.18 µM 1.63348617153142 0.0344827659448448 no 197 0.05118339337715 76 3360550 SGTC_501 nsc-95397 161 µM 1.63295069606397 0.0345281560194052 no 198 0.0512396832891915 81 262093 SGTC_1118 chelidonine 707.474 nM 1.6312361920521 0.0346738178157012 no 199 0.0514202456626432 58 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2431 5490079 200 µM 1.63106357729991 0.0346885108376851 no 200 0.0514384525280132 110 5722345 SGTC_1260 0700-1617 7.75 µM 1.6299284328574 0.0347852621113487 no 201 0.0515583117769081 88 2853078 SGTC_369 0957-0393 4.5 µM 1.62874761880893 0.0348861409306627 no 202 0.0516832288014116 86 6997992 SGTC_1392 3455-1037 33.9 µM 1.62630618953562 0.0350954777633711 no 203 0.0519422678660212 75 981132 SGTC_2679 rapamycin 1 nM 1.62431804899314 0.0352667084733784 no 204 0.0521539735601177 144 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1382 3002-2117 298 µM 1.61545803618895 0.0360381375335084 no 205 0.0531057704225337 79 1497314 SGTC_1421 4029-0249 71.4 µM 1.61004635390747 0.0365160863856931 no 206 0.0536938685870029 88 2894095 SGTC_2143 5623677 140.463 µM 1.60813150941378 0.0366864388727232 no 207 0.053903189764862 78 5375313 SGTC_2493 resveratrol 26.09 µM 1.59896306580083 0.0375111311717839 no 208 0.0549144047511402 47 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1656 st012921 11 µM 1.59797140633253 0.0376012301559009 no 209 0.0550246704115253 80 6732821 SGTC_3194 9111903 49.47 µM 1.59606261106613 0.0377751545068731 no 210 0.0552374076135395 80 17087251 SGTC_2287 7945887 168.79 µM 1.5925038610719 0.038101171417249 no 211 0.0556357681233876 94 1245853 SGTC_2975 9084847 53.72 µM 1.58342876026869 0.0389429383410278 no 212 0.0566618860458517 92 27211724 SGTC_422 cantharidin 155 µM 1.57861031196819 0.0393959949436629 no 213 0.0572127339618774 92 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_737 1950-0117 57.9 µM 1.57622297757442 0.0396220485804973 no 214 0.0574872124500848 97 5393513 SGTC_1583 clindamycin 39.6 µM 1.57181807592588 0.0400419112633942 no 215 0.0579963741068453 91 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2216 7189485 200 µM 1.57076210859655 0.0401430984270056 no 216 0.0581189582630667 75 731273 SGTC_2918 7977171 22.06 µM 1.56810213007814 0.0403989095083062 no 217 0.0584286497614592 85 2236483 SGTC_245 methotrexate 289.6 µM 1.56554299899175 0.0406462698665623 no 218 0.0587278216989605 90 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2584 androsterone 48.74 µM 1.56359732186878 0.0408351564253912 no 219 0.0589560821103473 107 2754130 A steroid. SGTC_781 4335-2806 94.4 µM 1.55814770324986 0.0413679991543203 no 220 0.0595991193582946 100 845254 SGTC_2063 5246145 200 µM 1.556429082406 0.0415372033324225 no 221 0.0598030470515464 107 711240 SGTC_1007 4101-0031 70 µM 1.55503874995162 0.0416744963056878 no 222 0.0599684204181649 99 1146276 SGTC_2226 7298446 200 µM 1.55080915649432 0.0420944228094812 no 223 0.0604737128197558 75 3283010 SGTC_2981 9013952 38.96 µM 1.54783435739224 0.0423918159653809 no 224 0.0608310910955533 81 2996344 SGTC_2603 homopterocarpin 100 µM 1.54753472279589 0.0424218646660153 no 225 0.0608671791343185 100 101795 A weak amylase inhibitor. SGTC_303 1348-1668 34.2 µM 1.54592270861101 0.0425838204621248 no 226 0.0610616177436821 86 5380509 SGTC_2759 disulfiram 3.38 µM 1.54332938749996 0.0428454149557019 no 227 0.0613754383974898 110 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_947 3447-0010 211 µM 1.53910333601621 0.0432744881656763 no 228 0.0618895353823215 106 748350 SGTC_2963 9082507 9 µM 1.53776381942988 0.043411211943306 no 229 0.0620531864792524 107 16459611 SGTC_2722 naftopidil 47.16 µM 1.53227554166458 0.0439750433399076 no 230 0.0627272270078122 87 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1900 st060200 72.8 µM 1.52796572674436 0.0444219341770006 no 231 0.063260523834616 100 688945 SGTC_1855 st056195 39.6 µM 1.52774859672785 0.0444445451681053 no 232 0.0632874846369193 85 4028379 SGTC_2692 st077426 47.7 µM 1.5260770076175 0.0446189279624601 no 233 0.0634953437034181 108 25238571 SGTC_410 α-linolenic acid 100 µM 1.51538548212974 0.0457473581410109 no 234 0.0648374058899709 101 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1690 st023502 41.2 µM 1.51296205141499 0.0460063001567814 no 235 0.0651446492542587 97 24207482 SGTC_338 4055-0136 114 µM 1.51080249252827 0.0462380385750495 no 236 0.0654193897431074 79 2900563 SGTC_1703 st026983 48.3 µM 1.51070549266253 0.0462484694147564 no 237 0.0654317511867967 71 1104023 SGTC_1308 1187-1617 41.4 µM 1.5087476099628 0.0464594137682212 no 238 0.0656816468426981 105 2882570 SGTC_29 0299-0004 12.984 µM 1.50708819503016 0.0466388049438884 no 239 0.0658940261330622 69 16871 A napthoquinone isolated from Swertia calycina. SGTC_3246 9135460 32.98 µM 1.50314425540833 0.0470673954841516 no 240 0.0664009243702952 93 41446951 SGTC_3190 9110366 49.47 µM 1.49936480200219 0.0474810686468161 no 241 0.0668895097861998 83 17123768 SGTC_3084 9116877 49.47 µM 1.49164820947521 0.0483347172333132 no 242 0.0678956964092456 77 27241325 SGTC_1374 2889-5571 141 µM 1.49122135496938 0.0483822940604996 no 243 0.0679516944016781 144 2853281 SGTC_119 0121-0043 24.815 µM 1.48923595558375 0.0486040773975458 no 244 0.0682126228745615 140 1092378 SGTC_617 3770-0098 35 µM 1.48835188919713 0.0487030951365226 no 245 0.0683290586680873 97 5962639 SGTC_2643 anethole 100 µM 1.48603912380433 0.0489628936662731 no 246 0.068634386398858 108 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1508 1080-0625 72.9 µM 1.48394094776849 0.0491995436429212 no 247 0.0689122937188027 99 767111 SGTC_1379 2144-0755 36.5 µM 1.48226229158332 0.0493895336252225 no 248 0.0691352588201542 102 5392327 SGTC_1939 st074455 53.6 µM 1.48197742583216 0.0494218327293494 no 249 0.0691731508143103 95 1644229 SGTC_592 k241-0073 46.5 µM 1.48123976360861 0.0495055498951933 no 250 0.0692713468169367 103 4230158 SGTC_1786 berberine 21.6 µM 1.47705639835982 0.0499824625243519 no 251 0.0698302599674623 125 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2523 spermine 47.74 µM 1.47363257526033 0.0503755059599394 no 252 0.0702902728226679 73 1103 A DNA binding polyamine. SGTC_2407 paclitaxel 400 µM 1.47300777175121 0.0504474963410466 no 253 0.0703744700956975 100 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1507 4075-3230 155 µM 1.47061270739307 0.0507242173058607 no 254 0.0706979427036223 83 659771 SGTC_3252 9135871 49.47 µM 1.46783600182429 0.0510465439369101 no 255 0.0710743877937607 91 17682838 SGTC_333 3486-0131 40.1 µM 1.46456705399909 0.0514280981651995 no 256 0.0715195380878253 106 6744690 SGTC_1101 ebselen 5.29 µM 1.46174694528479 0.0517590829289567 no 257 0.0719052837925823 122 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1228 0124-0032 52.5 µM 1.4614556116088 0.0517933718587537 no 258 0.0719452243220859 86 X1228 SGTC_1767 st044992 70.3 µM 1.46087665326857 0.0518615667690247 no 259 0.0720246473835783 90 9600693 SGTC_386 1509-0011 3.07 µM 1.45982470293428 0.0519856575190416 no 260 0.072169128764708 94 3107280 SGTC_172 1112-0046 2.638 µM 1.45941338410912 0.0520342418456006 no 261 0.0722256822166368 93 2802135 YIL048W NEO1 SGTC_1924 st058459 75.1 µM 1.45895393000915 0.052088554478579 no 262 0.0722888940834623 76 688683 SGTC_84 0443-0269 128.823 µM 1.45824105292399 0.0521729136858432 no 263 0.0723870558880212 101 6150058 SGTC_2237 6667747 47.222 µM 1.45453049467452 0.0526137609843411 no 264 0.0728996426378745 87 729940 YDL015C TSC13 SGTC_690 glyoxal 20.3 µM 1.44867562923188 0.0533153777908782 no 265 0.0737140947381489 126 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_657 3534-0529 86.7 µM 1.44811394205164 0.0533830754869913 no 266 0.0737925934982539 101 1049549 SGTC_1416 3966-0321 25.3 µM 1.44650509709208 0.0535773595820241 no 267 0.0740177917079111 107 582530 YLR208W SEC13 SGTC_836 0330-0104 1.35 µM 1.44396698081509 0.0538850009301756 no 268 0.0743741318095626 94 46494820 SGTC_1938 st074717 56.4 µM 1.44311763463561 0.0539882607006103 no 269 0.0744936682367771 94 17250979 SGTC_2182 6325192 200 µM 1.44279395045172 0.054027653998397 no 270 0.0745392619145347 96 736248 SGTC_27 0485-0001 32.618 µM 1.43659517197653 0.0547864620715599 no 271 0.075416528131955 92 2054479 SGTC_473 2-arachidonoylglycerol 10 µM 1.43523434416414 0.0549541668784247 no 272 0.075610164969176 106 5282280 An endocannabinoid. SGTC_2754 granisetron 64.02 µM 1.43290469244828 0.0552422084009502 no 273 0.0759425380486213 121 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2620 irigenin 100 µM 1.43252247236488 0.0552895803138523 no 274 0.0759971757390695 131 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_637 1181-0519 7.26 µM 1.43203318608232 0.0553502687017466 no 275 0.0760671620279909 117 6252091 YGR060W ERG25 SGTC_2646 retinol 96.75 µM 1.43136754307355 0.0554329158581363 no 276 0.0761624527092994 110 445354 A vitamin A analog and teratogen. SGTC_3132 9126706 49.47 µM 1.42426813983171 0.0563204610167532 no 277 0.0771844332834603 121 850858 SGTC_1725 st036284 20.55 µM 1.41990137175496 0.0568719208069115 no 278 0.077818198266602 99 707914 SGTC_265 mycophenolic acid 32.932 µM 1.41962102998172 0.0569074686754934 no 279 0.0778590198119345 92 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_260 nsc-65238 3.989 µM 1.41889468379823 0.0569996521449836 no 280 0.0779648612169749 106 3246252 SGTC_349 k015-0014 24 µM 1.41887931097367 0.0570016044407354 no 281 0.07796710248687 117 2196908 SGTC_791 1348-1292 225 µM 1.41266142761179 0.0577955806801362 no 282 0.0788776490589139 101 5437054 SGTC_2625 euphol 100 µM 1.41098837329938 0.0580106947335655 no 283 0.0791240211534154 128 6708538 A triterpene alcohol. SGTC_2101 5377231 179.231 µM 1.4089769570176 0.058270146320483 no 284 0.0794209909522058 127 2844213 SGTC_1660 st012960 28.1 µM 1.40811137437126 0.0583820775504702 no 285 0.0795490467416405 98 24207266 SGTC_244 nsc-207895 1.295 µM 1.40458563474776 0.0588397477260361 no 286 0.0800722653838405 54 42640 SGTC_478 N-arachidonylglycine 10 µM 1.40424802575837 0.0588837194621319 no 287 0.0801225026218426 56 5283389 SGTC_3063 1327-0034 4 µM 1.39869425573266 0.0596107747725411 no 288 0.0809523437633813 114 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2318 6029776 164 µM 1.39605675197268 0.0599585105476813 no 289 0.0813487029340854 117 818325 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.39530870038042 0.0600574243690264 no 290 0.0814613847774341 96 17037758 SGTC_276 colchicine 750 µM 1.39202604622247 0.0604929965281844 no 291 0.0819572554167289 115 2833 A microtubule depolymerizer. SGTC_273 hydroxyurea 18.1 mM 1.39089803165112 0.0606432409674589 no 292 0.0821281748958662 133 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_37 0566-0070 1.56 µM 1.38544462504374 0.0613737207723383 no 293 0.0829582768711632 108 1626686 SGTC_51 1013-0126 23.419 µM 1.37939462563545 0.0621921370624922 no 294 0.0838865576953228 88 1627850 SGTC_1275 0867-0008 21.1 µM 1.37664890947119 0.0625663623125682 no 295 0.0843104108114101 103 3422836 SGTC_3274 9138298 49.47 µM 1.3756198917393 0.0627070628411905 no 296 0.084469672474566 122 17015756 SGTC_829 1635-0120 117 µM 1.36961621304572 0.0635328848407842 no 297 0.0854033679219498 145 285054 SGTC_987 1497-1013 404 µM 1.36396662578325 0.0643177067700029 no 298 0.0862890348921435 111 1676435 SGTC_2483 5729050 27.16 µM 1.36301053610486 0.0644512658217419 no 299 0.086439595040143 117 2865180 SGTC_2463 5473429 200 µM 1.36214292867797 0.0645726509191143 no 300 0.0865763913673628 106 5399405 SGTC_1642 st009582 77.7 µM 1.35964552631788 0.0649230485086698 no 301 0.0869710619913422 135 6739311 SGTC_2421 5690543 90.72 µM 1.35726588900048 0.0652582946692996 no 302 0.0873483708398339 130 3397993 SGTC_376 3970-0862 59.1 µM 1.35397935904548 0.0657235114190275 no 303 0.0878714815144649 140 3135186 SGTC_744 1594-0068 283 µM 1.35040124525275 0.066232921390467 no 304 0.0884436558166799 123 668392 SGTC_1810 st050138 53 µM 1.35015144699016 0.0662685986233886 no 305 0.0884837043481707 140 3444541 SGTC_2379 9035213 200 µM 1.34409695685563 0.0671378859643293 no 306 0.0894585180232495 124 646551 SGTC_816 0325-0417 81.3 µM 1.34352678026643 0.0672202025686027 no 307 0.0895507302217995 128 68101 SGTC_1808 st050063 61.5 µM 1.34027251016265 0.0676915172119475 no 308 0.0900783826474692 114 4011993 SGTC_2010 4012422 159 µM 1.3401141932981 0.0677145111341865 no 309 0.0901041111867639 119 952393 SGTC_2526 patulin 37.61 µM 1.33905476131377 0.067868538223445 no 310 0.0902764231196647 145 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2034 5197015 53.07 µM 1.33839535146949 0.0679645440300349 no 311 0.0903837967208149 122 780676 SGTC_2893 9048488 25.97 µM 1.33719261142094 0.0681399252246844 no 312 0.0905798865276901 136 6467338 SGTC_1607 st000305 50.6 µM 1.33578635896658 0.0683454249765704 no 313 0.0908095564300356 109 5457690 SGTC_355 1311-2252 105 µM 1.33258424286949 0.0688151434994634 no 314 0.0913341394724106 117 5338538 SGTC_2919 7978188 46.38 µM 1.33146951726087 0.0689792454044156 no 315 0.0915172843032098 107 2980291 SGTC_1776 st049249 45.9 µM 1.32543651431543 0.0698726193138484 no 316 0.0925132064470664 138 1822314 SGTC_813 k007-0158 173 µM 1.32384788900655 0.0701093394508646 no 317 0.0927767839360476 109 6523916 SGTC_1636 st007707 68.9 µM 1.32081668739188 0.0705627280226404 no 318 0.09328124709162 122 403051 SGTC_884 0851-0618 334 µM 1.32046163458583 0.0706159817597452 no 319 0.0933404685590582 124 9642473 SGTC_731 3966-0296 387 µM 1.31885891537387 0.070856755253003 no 320 0.093608141776511 111 660956 SGTC_2994 9053520 71.4286 µM 1.31264405331666 0.0717963700695524 no 321 0.0946514589101011 102 4647384 SGTC_806 3966-4455 5.86 µM 1.31090657894292 0.0720607578399942 no 322 0.0949446639461008 109 714982 SGTC_2474 5321570 43.32 µM 1.30836747492404 0.0724484694177908 no 323 0.0953743494853391 120 2841384 SGTC_2400 5203494 178.7 µM 1.30548252358456 0.0728909277856596 no 324 0.095864297134804 148 6777674 SGTC_1608 st001473 40.5 µM 1.30475944898943 0.0730021476173998 no 325 0.0959873856188195 155 7292267 SGTC_272 doxorubicin 8.13 µM 1.30389436123631 0.0731353818262998 no 326 0.0961348015568182 136 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2180 6301957 200 µM 1.30371380014082 0.0731632139232684 no 327 0.0961655911924233 121 845462 SGTC_3071 9117417 49.47 µM 1.30278103663818 0.073307121292519 no 328 0.0963247633332838 119 45595590 YGL055W OLE1 SGTC_686 1319-0111 510 µM 1.29823619162506 0.0740114024710159 no 329 0.0971030925867122 136 4562600 SGTC_1834 st055981 52.8 µM 1.29821658318882 0.0740144522065131 no 330 0.0971064606082259 126 471719 YDL150W RPC53 SGTC_2876 9059903 25.97 µM 1.2968809741979 0.0742224079615359 no 331 0.0973360718764467 122 6916095 SGTC_1130 3454-2858 15.9 µM 1.29433202974916 0.0746205194107698 no 332 0.0977753787323593 152 715628 YIL048W NEO1 SGTC_3300 9124615 50.48 µM 1.29131351813396 0.0750940763867891 no 333 0.0982974924977532 114 24824903 SGTC_1908 st060353 56.5 µM 1.28998610702578 0.075303050383721 no 334 0.0985277409229035 145 4227716 SGTC_659 k018-0002 107 µM 1.28681153712926 0.0758046196936446 no 335 0.0990799923453613 124 6797879 YHR007C ERG11 SGTC_676 falcarinol 140 µM 1.28606585518972 0.0759228026526693 no 336 0.0992100396644567 133 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1013 4112-3890 241 µM 1.28464165014343 0.0761489144013429 no 337 0.099458768542974 130 705171 SGTC_1902 st060212 70.5 µM 1.2832032569172 0.0763777986106965 no 338 0.0997104376214352 126 688944 SGTC_2076 5212012 200 µM 1.28274780653917 0.0764503811232391 no 339 0.0997902225910534 111 604802 SGTC_493 zm226600 134 µM 1.27793206770516 0.0772210516320861 no 340 0.100636689969567 133 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2982 9019404 25.97 µM 1.27603235008691 0.0775266848120494 no 341 0.100972041830866 113 22333232 SGTC_3025 9087895 49.47 µM 1.27384122256847 0.0778803407625469 no 342 0.10135984628418 128 17173641 SGTC_640 3381-0960 37.1 µM 1.2708348029669 0.0783675784341545 no 343 0.101893712267061 134 1745025 SGTC_2411 st077133 39.94 µM 1.26975402376484 0.078543299399493 no 344 0.102086131229684 142 1403142 YNL221C POP1 SGTC_1693 xanthone 101.9 µM 1.26857690365795 0.0787350237844172 no 345 0.102296003091344 153 7020 An insecticide. SGTC_2453 5731132 22.18 µM 1.26796801854101 0.0788343354980083 no 346 0.102404685893327 152 1362040 SGTC_1946 st076057 65.1 µM 1.26770219467558 0.0788777222333246 no 347 0.102452160381195 105 953009 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.26724591355188 0.0789522368297835 no 348 0.10253368665547 158 5393153 SGTC_2014 4013930 200 µM 1.26600277238789 0.0791555229051711 no 349 0.1027560448443 128 64556 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.26327530098901 0.0796029241502678 no 350 0.103245129667715 128 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1100 amiodarone 5.07 µM 1.26171889731852 0.0798590850892707 no 351 0.103524977266093 98 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3340 9146634 11.102 µM 1.26065187320654 0.0800350612941341 no 352 0.103717150275276 105 4907387 SGTC_337 1315-0038 354 µM 1.26059216220469 0.0800449176327659 no 353 0.103727911978345 102 1626437 SGTC_452 diindolylmethane 8 µM 1.25812885474426 0.0804523296319763 no 354 0.104172579736227 117 3071 Inhibits expression of several cancer promoting factors. SGTC_1211 1056-0033 32.3 µM 1.25568375026294 0.0808582783822459 no 355 0.10461532652257 124 6741922 SGTC_1270 0831-1170 17.3 µM 1.25111484505004 0.0816209731273516 no 356 0.105446290096118 151 6764716 SGTC_3208 9114115 49.47 µM 1.25079857701464 0.0816739683142076 no 357 0.105503987096751 159 650895 SGTC_594 1487-1584 10.8 µM 1.24955040404976 0.081883370591674 no 358 0.105731915032548 143 5013332 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.24592562409271 0.0824937827418361 no 359 0.106395850900041 152 65057 A dermal irritant. YDR527W RBA50 SGTC_2858 9025781 8.96 µM 1.24579808069094 0.0825153232434559 no 360 0.106419267198665 143 4894980 YPL153C RAD53 SGTC_586 0957-0265 8.15 µM 1.24514694173589 0.0826253585430536 no 361 0.106538870884192 142 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2229 7354935 190 µM 1.24395989091971 0.0828262411670002 no 362 0.106757162553306 160 318112 SGTC_2628 lathosterol 100 µM 1.24033682038958 0.0834416396928039 no 363 0.107425419435004 133 6710616 SGTC_2464 5717415 7.67 µM 1.2384400456581 0.0837651847637318 no 364 0.107776469874778 128 5285744 SGTC_3257 9139206 32.98 µM 1.23126462378286 0.0849976708010291 no 365 0.109111954186446 131 4910041 SGTC_1450 4112-4260 37.6 µM 1.2301486325464 0.0851905741908401 no 366 0.109320725692506 147 1633175 SGTC_2797 7859098 81.82 µM 1.22968260623904 0.0852712256617185 no 367 0.109407991379812 145 972681 SGTC_1172 0370-0043 85 µM 1.22805074890458 0.0855540891275058 no 368 0.109713958908789 126 376585 SGTC_2478 5763493 32.33 µM 1.22544924931001 0.0860064808611691 no 369 0.110203000311449 140 1365576 YLR208W SEC13 SGTC_1451 4152-0210 104 µM 1.22498234231975 0.086087863468599 no 370 0.110290936785824 133 659563 SGTC_1272 0839-0021 27 µM 1.22299459698485 0.0864349753427308 no 371 0.110665868509705 145 5027250 SGTC_2745 rifampicin 24.3 µM 1.22189375785458 0.0866276600934244 no 372 0.110873903153381 79 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1458 k015-0034 6.33 µM 1.22031179584229 0.0869051198562759 no 373 0.111173349919058 122 3598957 SGTC_2107 5363541 170.161 µM 1.21938605412309 0.0870677930073516 no 374 0.111348850272904 135 244052 SGTC_502 l-744,832 89.3 µM 1.21823826635693 0.0872698001775307 no 375 0.11156672094502 125 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1941 st076221 61.8 µM 1.20888734908433 0.0889285878746373 no 376 0.113353063541635 146 2828568 SGTC_856 0433-0016 11.3 µM 1.20202124145173 0.0901614524338564 no 377 0.114677649198792 125 3911780 SGTC_1061 3448-9325 110 µM 1.20108002070824 0.0903314409145457 no 378 0.114860081147494 149 723482 SGTC_1309 pyrazolanthrone 13.4 µM 1.2004103186348 0.0904525368111377 no 379 0.114990011679806 162 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2989 9073649 71.4286 µM 1.19834172361979 0.0908273424201847 no 380 0.115392004827949 166 21367202 SGTC_3271 9137798 49.47 µM 1.19665069366488 0.0911345926785402 no 381 0.115721366349348 116 6498326 SGTC_3090 9117696 49.47 µM 1.19566155989218 0.0913146694315212 no 382 0.115914328937739 127 7923821 SGTC_2242 6630449 61.2675 µM 1.19556669133921 0.0913319545803827 no 383 0.115932848121943 128 691249 YDR170C SEC7 SGTC_152 4469-0003 551.229 µM 1.19531231288927 0.0913783145700072 no 384 0.115982515422738 169 697280 SGTC_788 1182-0090 188 µM 1.1947932275474 0.0914729710022501 no 385 0.116083913508678 148 5715185 SGTC_894 0960-0238 55.9 µM 1.19435184962388 0.0915535144567095 no 386 0.116170181719464 167 6741907 YDL195W SEC31 SGTC_1526 st051518 75 µM 1.19097260707349 0.0921719070619368 no 387 0.116832169394622 130 673993 SGTC_1322 1348-1070 12 µM 1.18982294445749 0.0923829956854753 no 388 0.117057994732314 145 6758089 SGTC_1906 st060206 94.7 µM 1.18926060291139 0.0924863769541149 no 389 0.117168566639731 152 5133468 SGTC_2773 thioridazine 9.09 µM 1.18788188341359 0.0927402038657267 no 390 0.117439974075998 134 5452 An antipsychotic. SGTC_1304 1165-0502 251 µM 1.18561050270291 0.0931594956238368 no 391 0.117888076333345 144 767425 SGTC_2275 7947463 200 µM 1.18330627340929 0.0935862809224237 no 392 0.118343893717555 157 1225414 SGTC_2890 9046729 58.44 µM 1.18213734740119 0.093803338558044 no 393 0.118575603746233 151 903329 SGTC_2736 butenafine 14.65 µM 1.17686472623091 0.0947870302045315 no 394 0.119624751515946 140 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3064 1327-0027 10 µM 1.1673092312126 0.0965890955898242 no 395 0.121542756029285 114 16000455 YPR107C YTH1 SGTC_1603 st002045 67.8 µM 1.16644659909418 0.0967530091459728 no 396 0.121716963641485 141 5887985 SGTC_1495 4469-0029 237 µM 1.16573259474639 0.0968888355513577 no 397 0.121861288692164 138 793680 SGTC_9 0092-0002 10.449 µM 1.16467377690579 0.0970905141444652 no 398 0.122075533767456 162 759368 SGTC_1715 st032160 10.2275 µM 1.16445508458247 0.0971322079839668 no 399 0.122119817709819 134 5289825 SGTC_2492 derrusnin 100 µM 1.16170462043046 0.0976577081442903 no 400 0.122677734129308 167 1715307 Part of coumarin class of compounds. SGTC_495 decylubiquinone 155 µM 1.16153493513695 0.0976901961369051 no 401 0.12271221231137 143 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2565 isoliquiritigenin 100 µM 1.1570323359048 0.0985551620436851 no 402 0.123629574714816 140 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_409 arachidonic acid 100 µM 1.15650588584692 0.098656659992499 no 403 0.123737146732264 144 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1054 3429-0080 167 µM 1.15287543360955 0.09935868371684 no 404 0.124480758359997 157 1162877 SGTC_2304 7443016 91.4 µM 1.14562728360412 0.100771175188412 no 405 0.125974701595455 128 939854 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.14223683244366 0.101436897348869 no 406 0.126677794906124 124 4000243 SGTC_1951 sophoraflavanone G 9.2 µM 1.14120230124469 0.101640666164647 no 407 0.12689287346487 142 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_967 1306-0166 352 µM 1.1406295618222 0.101753605202314 no 408 0.127012054988884 167 4437607 SGTC_739 1486-1183 203 µM 1.14027965213089 0.101822649172776 no 409 0.127084906130945 133 4346692 SGTC_3033 9090887 49.47 µM 1.13898580136013 0.102078247209533 no 410 0.127354538182113 160 19325384 SGTC_489 paxilline 115 µM 1.13893377853884 0.102088533983612 no 411 0.127365387793457 143 105008 A toxic potassium channel blocker. SGTC_215 1287-0124 461.5 µM 1.13622786394147 0.102624630504173 no 412 0.127930605931604 140 5560863 SGTC_1648 st011736 69.8 µM 1.1352326497945 0.102822316421845 no 413 0.128138926441708 163 2855514 SGTC_2848 9016370 25.97 µM 1.13486459502849 0.102895495599651 no 414 0.128216028157048 138 7894410 SGTC_175 3793-3120 23.7 µM 1.13354931149585 0.103157318533666 no 415 0.128491822737967 156 5322297 SGTC_317 4495-0002 170 µM 1.13225714780302 0.103415009991852 no 416 0.128763170158982 138 15991618 SGTC_1390 3413-2614 145 µM 1.13143881989978 0.103578447597851 no 417 0.128935220077966 178 3421432 SGTC_2475 5812728 15.03 µM 1.13131298635123 0.10360359587012 no 418 0.12896169017654 152 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1654 st012436 41.8 µM 1.12792874446796 0.104281611177005 no 419 0.129675006622671 144 4323132 SGTC_914 3820-6779 408 µM 1.127423048325 0.104383200322116 no 420 0.129781829379951 130 2893481 SGTC_1989 st071868 50.2 µM 1.12444426188083 0.104983063453702 no 421 0.130412301875356 162 16414057 SGTC_545 4218-0007 221 µM 1.1216309760033 0.105551885965814 no 422 0.131009687735651 166 2840508 SGTC_749 1000-0129 128 µM 1.12084415718976 0.105711372159437 no 423 0.131177102211804 146 708470 SGTC_3060 1327-0027 12.5 µM 1.12027891152313 0.105826053519675 no 424 0.131297462884274 156 16000455 YPR107C YTH1 SGTC_2299 7976368 114.88 µM 1.11933760547306 0.106017232409221 no 425 0.131498069235095 140 2979718 SGTC_3339 9145883 14.936 µM 1.11834531724009 0.106219035823219 no 426 0.13170976961905 140 2030670 SGTC_933 2914-0560 114 µM 1.11195069689036 0.107526178913185 no 427 0.133079674639729 146 463887 SGTC_1876 myriocin 605 nM 1.11159143549924 0.107599959012807 no 428 0.133156928296289 165 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1295 1013-0063 9.78 µM 1.11053066959668 0.107818017182011 no 429 0.13338520982044 157 6826038 SGTC_1181 1222-0449 220 µM 1.11026565736017 0.107872544538206 no 430 0.133442283635275 158 658318 SGTC_2384 9036245 200 µM 1.1098573439997 0.107956595558342 no 431 0.133530252075887 124 6462766 SGTC_812 4251-0442 148 µM 1.10963885420894 0.108001590893843 no 432 0.133577340647693 163 5723007 SGTC_506 n9-isopropylolomoucine 153 µM 1.10800342339575 0.10833881700268 no 433 0.133930168714839 135 6610355 SGTC_2809 7964133 12.99 µM 1.10718137594408 0.108508609198527 no 434 0.134107759000599 162 1253665 SGTC_2639 lactacystin 53 µM 1.10637664765737 0.108675009504218 no 435 0.134281764389737 150 3870 A proteasome inhibitor. SGTC_716 1683-5115 658 µM 1.1021512338532 0.109551745178185 no 436 0.135197964389684 169 723597 SGTC_2114 5491910 81.25 µM 1.09938722000701 0.110127994416435 no 437 0.135799601395489 151 2849228 SGTC_1263 0774-1208 64.8 µM 1.09583642609906 0.110871460244408 no 438 0.136575182228669 185 906585 SGTC_1949 st076024 69.1 µM 1.09441544036144 0.111169991643794 no 439 0.136886407554418 190 2921930 SGTC_1351 1496-0003 46.5 µM 1.09358197607007 0.111345359678838 no 440 0.13706917887282 167 3891978 SGTC_2935 9038016 29.96 µM 1.09354449991173 0.111353249633434 no 441 0.13707740097686 160 6463195 SGTC_2714 st079313 56.9 µM 1.08988985314494 0.112124595475569 no 442 0.137880833417644 142 2939799 SGTC_3047 9092122 49.47 µM 1.08954703282026 0.112197146226808 no 443 0.137956363030331 163 17173831 SGTC_2310 7668677 200 µM 1.08737896945039 0.112656748621433 no 444 0.138434680771596 190 2197143 SGTC_2899 9053889 58.44 µM 1.08436373120535 0.113298174418322 no 445 0.139101779041246 159 6470052 SGTC_724 3910-0327 137 µM 1.08416672700766 0.113340173221079 no 446 0.139145440726947 176 2885483 SGTC_2553 4-methylesculetin 85.09 µM 1.08391230259278 0.113394429717653 no 447 0.139201842152263 144 5319502 SGTC_33 0986-0033 35.816 µM 1.08381514461605 0.113415153730168 no 448 0.13922338447417 134 2848082 SGTC_2796 7949634 45.45 µM 1.08341159366937 0.113501260954759 no 449 0.139312885961443 173 2971588 SGTC_1445 4239-0156 97.7 µM 1.08265469436798 0.113662889175202 no 450 0.139480860312712 172 4008346 SGTC_3015 9080845 49.47 µM 1.08048711554789 0.114126661343343 no 451 0.139962660636066 165 5296973 SGTC_90 0870-0863 4.608 µM 1.07827290597666 0.114601800602523 no 452 0.140455992284512 185 1738164 SGTC_2130 NSC 7 2.4545 µM 1.07763646047767 0.114738633264805 no 453 0.140598012173095 167 21448 SGTC_3314 9135860 59.4275 µM 1.07691279903695 0.11489435810916 no 454 0.140759612281359 160 25252478 SGTC_759 3486-0358 89.3 µM 1.07467632000965 0.115376576542654 no 455 0.141259834570444 177 875103 SGTC_1320 1313-0481 95.3 µM 1.07429125977035 0.11545974624009 no 456 0.141346080559242 140 6813365 YLR208W SEC13 SGTC_670 4204-0025 119 µM 1.07358499337177 0.115612404416381 no 457 0.141504363219167 156 719039 SGTC_2546 rhodinyl acetate 100 µM 1.07196073190642 0.115964029460276 no 458 0.141868835020026 170 6708682 SGTC_344 k064-0035 6.43 µM 1.06948118829635 0.116502271661277 no 459 0.142426450494583 172 5088750 SGTC_3226 9131256 49.47 µM 1.0682617520375 0.116767627481402 no 460 0.142701228168934 153 17178073 SGTC_751 0833-0568 350 µM 1.06707490567216 0.117026302750524 no 461 0.142969006254875 166 6954252 SGTC_109 0132-0036 33.701 µM 1.06636346340892 0.117181557376381 no 462 0.143129685614916 150 67274 A color developer. SGTC_2375 9072683 200 µM 1.06566869052847 0.117333315092991 no 463 0.143286717886041 175 16798029 SGTC_1414 3917-0015 5.4 µM 1.06413413347017 0.117668998128256 no 464 0.143633969985758 167 6618702 SGTC_1274 0865-0114 173 µM 1.0637745286848 0.117747759577775 no 465 0.143715426366242 164 870624 SGTC_1546 5-methoxyflavanone 78.7 µM 1.06347056313941 0.117814363886567 no 466 0.143784303852482 151 147795 SGTC_2933 9026794 32.47 µM 1.062313673315 0.118068103025506 no 467 0.144046654548715 171 17586027 SGTC_2274 7947094 46.08 µM 1.05873791167383 0.11885481300334 no 468 0.144859578475261 164 2971028 SGTC_1809 st050081 57.6 µM 1.0581335065469 0.118988154249552 no 469 0.144997290276762 182 5036894 SGTC_530 4358-1714 28 µM 1.05743114826957 0.119143238152727 no 470 0.145157431069602 191 1564641 SGTC_798 1287-0182 476 µM 1.05620093365069 0.119415218873265 no 471 0.145438212158312 178 1649755 SGTC_2444 5485484 36.41 µM 1.05588085531484 0.119486054821966 no 472 0.145511325879043 185 6790631 SGTC_1432 4049-0298 68.4 µM 1.05416091330588 0.119867199660357 no 473 0.145904625926888 160 741646 SGTC_3086 9117350 49.47 µM 1.05405032948327 0.119891734695336 no 474 0.145929937606788 134 2679265 SGTC_2765 myclobutanil 7.74 µM 1.05271018942789 0.120189350630843 no 475 0.146236918618913 189 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2756 carbadox 75.1 µM 1.05149684691834 0.120459256267536 no 476 0.146515228396625 192 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1851 st056236 18.9 µM 1.05106260356255 0.120555956487391 no 477 0.14661491906164 164 5393171 SGTC_1958 st076513 41.9 µM 1.05088757949564 0.120594947470747 no 478 0.146655112776438 176 732122 YGL099W LSG1 SGTC_760 0568-0725 82.9 µM 1.05012392144838 0.120765175263408 no 479 0.146830570901409 184 3916171 SGTC_705 1124-0212 310 µM 1.04895171212741 0.121026802581546 no 480 0.147100171665681 204 9554485 SGTC_665 3914-0008 307 µM 1.04475802602897 0.121966062554901 no 481 0.148067409428411 171 1069549 SGTC_1782 st039423 80.636 µM 1.04217761605675 0.12254653502085 no 482 0.148664669419119 158 2068169 SGTC_2881 9058953 51.95 µM 1.04175010728827 0.122642891508766 no 483 0.148763775611162 169 17122249 SGTC_2184 6075246 200 µM 1.04087992433631 0.122839186790104 no 484 0.148965640068223 173 2267320 SGTC_2061 5245884 80.95 µM 1.03736036558801 0.123635373714518 no 485 0.149783971211462 183 573863 SGTC_1516 st013856 110 µM 1.03725118891266 0.123660129077624 no 486 0.149809403695955 165 5281404 A mutagen and neurotoxin. SGTC_1815 st051655 58.2 µM 1.03112930590297 0.125053797932297 no 487 0.151240093304838 186 5984156 SGTC_544 k015-0020 52.4 µM 1.0275570856379 0.125872076788247 no 488 0.152079109824155 189 3008304 SGTC_111 0083-0039 52.457 µM 1.02535298246549 0.126378823668 no 489 0.152598332318674 145 759313 SGTC_1248 0469-0687 58.6 µM 1.02411753616835 0.126663486858929 no 490 0.152889881249986 175 4017482 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.023201432417 0.126874857413339 no 491 0.153106307906813 192 5282309 SGTC_3059 1327-0034 3 µM 1.01326214495175 0.129183916749713 no 492 0.155467481935265 167 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1383 3049-0032 20.7 µM 1.01315605649327 0.129208718958974 no 493 0.15549281317449 193 712864 SGTC_5 0352-0601 109.883 µM 1.01293772636443 0.129259772310957 no 494 0.155544953452189 159 762456 SGTC_1632 st005650 90 µM 1.01200593111437 0.129477816357916 no 495 0.155767608781539 172 2759605 SGTC_3283 9109332 35.8195 µM 1.01188524572761 0.129506075881012 no 496 0.155796462289536 149 17027281 SGTC_1667 st014849 34.6 µM 1.00759131402401 0.130514318599843 no 497 0.156825350260489 189 5348460 SGTC_986 1493-0483 84 µM 1.00580598491474 0.130935118841307 no 498 0.157254453883534 187 40079 SGTC_941 3237-0776 460 µM 1.00540829295659 0.131028981964754 no 499 0.157350144126515 174 760008 SGTC_3293 9120939 62.045 µM 1.00361045510055 0.131453887108289 no 500 0.157783206582411 184 934087 SGTC_1964 st076914 61 µM 1.00219384036389 0.13178936247336 no 501 0.158124991083411 214 24208661 SGTC_2891 9063876 19.48 µM 0.999409857888798 0.132450370683143 no 502 0.158798093180967 158 6472478 SGTC_3173 9105693 49.47 µM 0.999112265436491 0.132521163755264 no 503 0.158870155052213 177 17096658 SGTC_2742 clothiapine 36.27 µM 0.997809969397134 0.132831268371517 no 504 0.159185757496801 141 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1845 st056753 3.01 µM 0.996796364227003 0.133072975056519 no 505 0.15943168170533 171 5375839 SGTC_419 nsc-638432 893 µM 0.996394224173916 0.133168954151546 no 506 0.159529319122759 182 368090 SGTC_1058 3448-5425 97.3 µM 0.996029938880588 0.133255939534675 no 507 0.159617799388802 200 7279705 SGTC_1226 3909-7979 35.4 µM 0.995086963655868 0.133481288182956 no 508 0.159846985219211 200 6615510 SGTC_3004 9076122 71.4286 µM 0.994978400944463 0.13350724890356 no 509 0.159873384702529 188 44782551 SGTC_1337 1486-1011 40.3 µM 0.994783167336433 0.133553944068149 no 510 0.159920867353941 174 X1337 SGTC_618 k072-0232 33.2 µM 0.99408391485067 0.133721280522636 no 511 0.160091007811988 197 5872756 YGL099W LSG1 SGTC_1262 0737-0114 49.6 µM 0.992470473385913 0.134107939193895 no 512 0.160484037993071 200 765919 SGTC_1040 k898-0338 155 µM 0.992286103355994 0.134152172027388 no 513 0.160528990157133 209 20969351 SGTC_2748 diazoxide 86.69 µM 0.991784326147906 0.13427260583362 no 514 0.160651372578755 130 3019 A potassium channel activatior. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.985155276068895 0.135870645591986 no 515 0.162273902593872 196 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1878 temozolomide 1 mM 0.984828487858478 0.135949758599351 no 516 0.162354162424087 183 5394 DNA alkylating agent. SGTC_2513 baicalein 25.65 µM 0.982484259801111 0.136518203431218 no 517 0.162930666822129 192 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_380 3970-0968 6 µM 0.982378477115497 0.136543892633557 no 518 0.162956712780933 188 2891601 SGTC_2563 tomatine 8.54 µM 0.981387940895571 0.136784603622614 no 519 0.163200735316534 184 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2792 7535235 81.82 µM 0.979914436596653 0.137143217506489 no 520 0.163564178073071 185 1281891 SGTC_36 0335-0881 14.2 µM 0.97889095526059 0.137392684796275 no 521 0.163816930842278 195 23828853 SGTC_1967 st070177 51.4 µM 0.973816898685777 0.138634029455672 no 522 0.165073730495908 193 5729214 SGTC_2781 5567276 71.43 µM 0.97358384817428 0.138691227138516 no 523 0.165131604625664 199 2853274 SGTC_1750 st081859 2.357 µM 0.971025185480108 0.139320257852232 no 524 0.165767868536279 214 5291695 SGTC_2875 9039966 71.43 µM 0.970648986497348 0.139412907366873 no 525 0.165861551593695 182 6463691 SGTC_96 0929-0093 37.281 µM 0.9687424099533 0.139883099520035 no 526 0.166336863442139 215 6991579 SGTC_485 niflumic acid 177 µM 0.966235854804293 0.140502894186724 no 527 0.166963087657373 186 4488 A COX2 inhibitor. SGTC_3183 9108214 49.47 µM 0.966009083283212 0.140559059691661 no 528 0.167019817939791 145 4974831 SGTC_1447 4239-0816 81.9 µM 0.964616840916608 0.140904216500215 no 529 0.167368380540671 196 1341554 SGTC_1552 6-methylflavone 10.6 µM 0.961091675854482 0.141780724598742 no 530 0.168253037371366 184 689013 SGTC_1134 3477-0009 42.5 µM 0.960404444661899 0.141952029107018 no 531 0.168425851014766 193 3973534 SGTC_1135 dihydrocapsaicin 536.708 nM 0.958508660143915 0.142425313092081 no 532 0.168903163338055 205 107982 A Capsaicinoid. SGTC_1078 idebenone 36.1 µM 0.957072130061223 0.142784653944938 no 533 0.169265424741094 215 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2225 6654152 15.4 µM 0.955699856343054 0.143128493267337 no 534 0.169611947558489 195 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2385 9074692 200 µM 0.954994062566114 0.143305555847913 no 535 0.169790349776468 180 17046906 SGTC_2481 5478948 45.16 µM 0.954963826049203 0.143313144589849 no 536 0.169797995293276 184 77792 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.953777018050731 0.14361122329312 no 537 0.170098262461246 197 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3336 9143619 71.43 µM 0.953317121092747 0.143726843426578 no 538 0.170214709657481 185 45595730 SGTC_3277 9138724 49.47 µM 0.952764558008244 0.143865843284289 no 539 0.17035468771127 150 15943418 SGTC_1068 loratadine 26.9 µM 0.952052645069875 0.14404506199509 no 540 0.170535141733179 186 3957 A H1 histamine antagonist. SGTC_808 0711-0032 135 µM 0.943365352248605 0.146244149993884 no 541 0.172747029482538 211 4252555 SGTC_3203 9113543 49.47 µM 0.940518107655714 0.146969777370534 no 542 0.173475932955827 200 17018012 SGTC_886 0866-0150 153 µM 0.939207607447478 0.147304571687625 no 543 0.1738120819661 198 271463 SGTC_2 0422-0095 29 µM 0.937002401429588 0.147869089958644 no 544 0.174378661325851 186 6790840 SGTC_733 4069-0007 56.1 µM 0.935744888715891 0.148191652593388 no 545 0.174702276368461 207 5717425 YNL287W SEC21 SGTC_3105 9121040 49.47 µM 0.935233388964926 0.148322991196462 no 546 0.174834017464055 168 41448907 SGTC_1783 st039459 87.517 µM 0.931643096010829 0.149247067363169 no 547 0.175760501673522 211 729761 SGTC_2907 7721985 69.9 µM 0.93068859575681 0.149493383866362 no 548 0.176007335280774 180 3267881 SGTC_2284 7945075 39.21 µM 0.92905710547805 0.149915031004524 no 549 0.17642974631307 220 1245402 SGTC_588 3970-1144 52.9 µM 0.928715824082851 0.150003332976861 no 550 0.176518188915081 163 1888707 SGTC_31 0508-1974 57.237 µM 0.927855310230046 0.150226133297833 no 551 0.176741314356194 182 6810525 SGTC_2838 9002687 71.43 µM 0.926890507488439 0.150476197766419 no 552 0.176991693131611 208 6457060 SGTC_2235 salicylic acid 500 µM 0.924349915343709 0.151136012407995 no 553 0.177652081105195 191 338 A COX inhibitor and kinase inhibitor. SGTC_990 3985-0011 41.3 µM 0.92246325199978 0.151627239499521 no 554 0.178143494985885 203 5399565 YGL099W LSG1 SGTC_3185 9108267 49.47 µM 0.91843959562491 0.152678413003114 no 555 0.179194384526628 211 4910486 SGTC_2761 levamisole 97.89 µM 0.916912243868184 0.15307869386356 no 556 0.179594313730586 176 26879 An alkaline phosphatase inhibitor. SGTC_2954 9074818 52.69 µM 0.914703466356511 0.153658788713652 no 557 0.180173662058668 212 16648742 SGTC_1381 2324-0066 62.1 µM 0.912396910947846 0.154266114692788 no 558 0.180779907535952 208 10885928 SGTC_1873 rapamycin 2 nM 0.910931142835905 0.154652881562845 no 559 0.181165827690766 190 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3052 9092717 49.47 µM 0.90984601664625 0.154939622273731 no 560 0.181451861305623 220 25237534 SGTC_1039 k821-0043 94 µM 0.90896573349898 0.155172491738323 no 561 0.181684106933485 191 15992768 SGTC_2333 9017922 200 µM 0.907396361767616 0.155588225052537 no 562 0.18209861634844 199 3163164 SGTC_106 0092-0003 11.579 µM 0.90666646718612 0.155781827342496 no 563 0.182291600599382 192 1072148 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.905469632758222 0.156099627623562 no 564 0.182608320305199 204 2333 A French combination drug. SGTC_1280 0880-0253 10.1 µM 0.904571044935023 0.156338513876793 no 565 0.182846340375599 220 6836607 SGTC_2936 9038235 15.59 µM 0.902703366111345 0.15683579934056 no 566 0.183341674735262 212 4749415 SGTC_1209 2323-2347 50.3 µM 0.901887305045779 0.157053408971201 no 567 0.183558367866893 193 5412760 SGTC_1864 st057645 30.4 µM 0.90179853095353 0.15707709330987 no 568 0.183581950156639 227 688666 SGTC_2156 5649887 115 µM 0.901602101692711 0.157129507682269 no 569 0.183634137088024 211 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2518 prenyletin 46.28 µM 0.901551669591962 0.157142966631102 no 570 0.183647537278458 176 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2380 9035439 200 µM 0.90049663957123 0.15742469911675 no 571 0.183928006416941 191 6462575 SGTC_1811 st050069 61.5 µM 0.899100386353272 0.157798061054669 no 572 0.184299596167433 207 3877702 SGTC_150 3970-0969 77.2 µM 0.898336337060039 0.158002615928438 no 573 0.184503132885692 249 6615640 SGTC_151 3013-0144 2.285 µM 0.896536069487989 0.158485280070344 no 574 0.184983262527732 232 906558 YHR107C CDC12 SGTC_497 capsazepine 133 µM 0.895562497855675 0.158746703820252 no 575 0.185243236288025 210 2733484 A calcium channel blocker. SGTC_2021 4019055 173 µM 0.894194745947106 0.15911445025505 no 576 0.185608851448335 239 44827708 YER133W GLC7 SGTC_2705 st078069 42.8 µM 0.893555128370978 0.159286615114389 no 577 0.185779981828346 191 1530061 SGTC_188 3229-0966 278.469 µM 0.8918992199803 0.159732899899965 no 578 0.186223476396333 225 5722370 SGTC_3324 9138759 60.749 µM 0.890363988965389 0.160147391011489 no 579 0.186635236054572 199 45595710 SGTC_2533 agelasine 13.65 µM 0.890316303132267 0.160160276775576 no 580 0.186648034747275 196 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.889939744233201 0.160262055105854 no 581 0.18674912078266 219 4620898 SGTC_1634 st006576 41 µM 0.889828164241996 0.160292221653192 no 582 0.186779080582696 208 3915356 SGTC_1712 st032288 53.4 µM 0.886285701177093 0.161251884104914 no 583 0.187731796097479 224 2883011 SGTC_193 1273-0060 1.558 µM 0.88551778384109 0.161460408184974 no 584 0.187938716171892 211 2847393 YHR072W ERG7 SGTC_3151 9099821 49.47 µM 0.88372589347317 0.161947670510827 no 585 0.188422099487033 224 17174189 SGTC_32 0928-0142 34.1 µM 0.883137115000995 0.162107983801966 no 586 0.188581096570143 221 2244242 SGTC_54 0159-0055 9 µM 0.881398594504041 0.162581953091193 no 587 0.189051059066494 211 3319099 SGTC_991 3996-0057 64.7 µM 0.881396392438052 0.162582554007102 no 588 0.18905165479318 195 715343 SGTC_2069 5228469 200 µM 0.880922206286965 0.162711987058717 no 589 0.189179963685456 220 2835210 SGTC_2301 7769476 200 µM 0.879882143704533 0.162996115444112 no 590 0.189461579456412 200 977820 SGTC_2605 digitonin 300 nM 0.878880530004007 0.163270044898186 no 591 0.189733028209932 232 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1206 3978-0017 132 µM 0.878538327617521 0.163363701700685 no 592 0.189825823758528 208 3873677 SGTC_2486 5283202 22.39 µM 0.877717541642894 0.163588483464149 no 593 0.190048511273903 205 1377751 SGTC_60 0986-0278 202 µM 0.877306343281617 0.163701170378491 no 594 0.190160133879607 212 3110598 SGTC_2081 5214970 32.255 µM 0.875158217620937 0.16429067279555 no 595 0.190743911937452 183 2063512 SGTC_864 0469-0573 172 µM 0.874922059753997 0.164355564628939 no 596 0.190808157609039 219 689425 SGTC_312 4092-0653 6.84 µM 0.874674481714653 0.164423612355039 no 597 0.190875524340782 226 1148278 SGTC_1590 st077108 57.8 µM 0.874664002862373 0.164426492908566 no 598 0.190878375989951 190 5489485 SGTC_2327 6189656 200 µM 0.873947600498458 0.164623503812911 no 599 0.191073395209252 213 5349088 SGTC_2459 5811157 9.22 µM 0.873395011303151 0.164775570486892 no 600 0.191223904610385 221 2870684 YBR192W RIM2 SGTC_2372 9071633 200 µM 0.873067189652375 0.164865826509975 no 601 0.191313228136291 205 21321366 SGTC_3210 9128157 49.47 µM 0.870979584480406 0.165441338039082 no 602 0.191882650167879 193 17590849 SGTC_591 4299-0174 154 µM 0.868989638362142 0.165991135288539 no 603 0.192426399120251 226 5509088 SGTC_2402 5553605 200 µM 0.868047958965867 0.166251720625976 no 604 0.192684039279269 209 6758546 SGTC_2347 9049783 174.81 µM 0.865383302357455 0.166990525976695 no 605 0.193414221322169 240 6467988 YPL169C MEX67 SGTC_1942 st076330 65.2 µM 0.865235289325141 0.16703162619673 no 606 0.19345482999677 228 24208414 SGTC_567 1080-0542 68.4 µM 0.865082400942726 0.167074087051152 no 607 0.193496781727178 187 5950415 SGTC_3329 9141233 27.5565 µM 0.862958925964388 0.167664547684832 no 608 0.194080025207238 212 4909101 YNL103W MET4 SGTC_3242 9133940 49.47 µM 0.862789557076794 0.167711700772873 no 609 0.194126590924584 205 17248444 SGTC_2747 doxorubicin 7.63 µM 0.859699457247682 0.168573497940045 no 610 0.194977367023128 164 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2993 9054257 71.4286 µM 0.858403608742967 0.168935742536058 no 611 0.195334817796525 241 6470217 YGL055W OLE1 SGTC_1889 st059080 5.18 µM 0.854049005025027 0.170156699289615 no 612 0.196538918667269 204 176925 Isolated from Daphnopsis sellowiana. SGTC_3075 9116269 49.47 µM 0.852506190765482 0.170590631361597 no 613 0.196966602228504 218 17015205 YNL244C SUI1 SGTC_1125 tnp00248 1.32998 µM 0.852323241612312 0.170642134603596 no 614 0.19701735490244 245 24207736 SGTC_1282 0886-0010 32.4 µM 0.850673507949821 0.171107011699211 no 615 0.197475371687334 227 2836211 YNL267W PIK1 SGTC_2496 diffractaic acid 79.83 µM 0.849541767427069 0.171426391904252 no 616 0.197789949658507 221 94870 An apoptosis inducer which activates caspases. SGTC_597 k018-0003 82.8 µM 0.849449629582517 0.171452410212629 no 617 0.197815573564968 240 6786234 SGTC_1905 st060207 84.5 µM 0.848861802566715 0.17161846291872 no 618 0.197979097841807 218 1948547 SGTC_1954 st077032 68.9 µM 0.848823483908465 0.171629290956509 no 619 0.197989760326619 245 698907 SGTC_541 4513-1321 94 µM 0.848207840741696 0.171803318457357 no 620 0.198161115693456 226 747515 SGTC_1553 gossypol 38.6 µM 0.846173994855145 0.172379038511211 no 621 0.198727843425287 214 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_685 1278-0033 54.9 µM 0.845101566194384 0.172683105493269 no 622 0.199027066976525 234 3590572 SGTC_62 0180-0423 3.232 µM 0.845075753302336 0.172690428465069 no 623 0.199034272501607 243 30102 YGL099W LSG1 SGTC_352 k048-0007 5.11 µM 0.841981628039419 0.173569648240839 no 624 0.199899118575467 250 6811911 SGTC_1296 1068-0102 11.9 µM 0.840542093827621 0.173979672300615 no 625 0.200302255214214 218 767053 SGTC_972 1319-0219 195 µM 0.839911420902567 0.174159501388552 no 626 0.200479026786028 241 23903702 SGTC_3288 9119690 36.221 µM 0.838072860850706 0.174684419428453 no 627 0.200994891981664 234 17595618 YKL019W RAM2 SGTC_2782 7736369 71.43 µM 0.837389975679838 0.174879642102524 no 628 0.201186699280707 237 2950836 YOL077C BRX1 SGTC_1112 tnp00069 1.16933 µM 0.836811198203518 0.175045210915276 no 629 0.201349350938595 216 145826 SGTC_328 k915-0120 63.5 µM 0.835982228184768 0.175282524578962 no 630 0.201582450512058 200 6624543 SGTC_1493 4348-0038 111 µM 0.834794049495351 0.175623026411586 no 631 0.201916838406039 254 800424 SGTC_2094 5332512 191.667 µM 0.834051914322052 0.175835916011331 no 632 0.20212586510798 233 755774 SGTC_3213 9129884 49.47 µM 0.829593588393708 0.177118273834643 no 633 0.203384301523121 213 17190742 SGTC_1114 scopoletin 1.73284 µM 0.829498153119094 0.177145788514674 no 634 0.203411290716908 224 5280460 A coumarin with genotoxic properties. SGTC_2369 9071472 200 µM 0.825025242121311 0.178438388872596 no 635 0.204678630027881 226 17296037 SGTC_360 0957-0399 1.01 µM 0.824308255627555 0.178646137798329 no 636 0.204882214464311 230 6752301 YPR165W RHO1 SGTC_2074 5212007 75.395 µM 0.824017618984732 0.178730393977791 no 637 0.204964773451073 225 758611 SGTC_687 k029-0044 34.9 µM 0.822976225495661 0.179032501544886 no 638 0.205260756696786 202 5829338 SGTC_2177 5811945 192 µM 0.820708901042789 0.179691361370753 no 639 0.205906049748957 225 5343475 SGTC_3065 9113888 49.47 µM 0.819209294347517 0.180127966703979 no 640 0.206333506503674 228 16648368 SGTC_1730 st033808 45.1 µM 0.81826643647491 0.180402817214837 no 641 0.206602533346314 230 1045166 SGTC_833 3852-0053 558 µM 0.817744440816691 0.18055509616602 no 642 0.206751564338337 245 3123681 SGTC_1132 3456-3614 2.5 µM 0.815332311604863 0.181259820029453 no 643 0.207441059067597 211 3125502 SGTC_1001 4048-4355 44.4 µM 0.814880601591903 0.181391982156864 no 644 0.207570328985581 242 21824233 SGTC_1617 st002906 78 µM 0.813379492299694 0.181831612642762 no 645 0.208000256752377 236 5150859 SGTC_2877 9040724 71.43 µM 0.813210703075511 0.181881087661195 no 646 0.208048631974875 213 6463895 SGTC_2490 carminic acid 95.39 µM 0.81274917430352 0.182016412645886 no 647 0.208180940653883 218 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_69 0096-0274 206.684 µM 0.811388202891044 0.182415829878977 no 648 0.208571385867207 275 6741392 SGTC_1872 amphotericin b 148 nM 0.810451184411884 0.182691143635522 no 649 0.208840455198397 225 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3237 9133362 49.47 µM 0.807563733068261 0.183541161835745 no 650 0.20967088576117 233 43845137 SGTC_3296 9122258 64.045 µM 0.807488850462714 0.183563238784284 no 651 0.209692447787746 216 4730474 SGTC_1377 2944-0135 198 µM 0.807101017825214 0.183677606387014 no 652 0.20980414288457 213 1894137 SGTC_1240 0356-0016 42.1 µM 0.806307592297784 0.18391171718045 no 653 0.210032756937196 223 4305613 SGTC_1814 st052110 31.539 µM 0.805378208124566 0.184186180588368 no 654 0.210300731551088 233 674163 SGTC_1192 1488-0095 21.4 µM 0.804618034964716 0.184410862454148 no 655 0.210520065778657 237 915875 SGTC_1384 3089-0840 101 µM 0.801895763219895 0.185216873055511 no 656 0.211306628561783 214 1069836 SGTC_2426 5582046 32.21 µM 0.79913236071986 0.186037295578745 no 657 0.212106833574011 226 2251934 SGTC_1775 st081588 35.1725 µM 0.796395734061406 0.186851985214405 no 658 0.21290102848427 239 1426443 YGL099W LSG1 SGTC_1927 st060202 13.8 µM 0.79540705997856 0.187146854091186 no 659 0.21318837724442 240 688887 SGTC_1643 st009866 20.2 µM 0.795286379445326 0.187182866371404 no 660 0.213223467381537 222 3156273 YOR207C RET1 SGTC_1940 st075990 51.1 µM 0.793149391132306 0.187821274756018 no 661 0.213845394652578 254 1084979 SGTC_3326 9140064 16.379 µM 0.791796745146358 0.188226061149522 no 662 0.214239600252073 239 1868434 SGTC_1203 3992-3522 103 µM 0.791187657426178 0.18840850947288 no 663 0.214417246429663 253 5322312 SGTC_1197 1601-0112 267 µM 0.785825511519986 0.190019409164603 no 664 0.21598485922134 258 7350313 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.785638602646865 0.190075712723716 no 665 0.21603962115011 217 77254 SGTC_2479 5617353 43.85 µM 0.784878723130307 0.190304720848051 no 666 0.216262339008996 244 2731746 SGTC_2920 7982904 15.77 µM 0.783056201568235 0.190854672264471 no 667 0.216797054716224 223 6456808 SGTC_1762 st045503 25.4615 µM 0.782619255763484 0.190986666754753 no 668 0.216925365225476 232 4645554 SGTC_2673 kobusone 100 µM 0.781782566006867 0.191239573848507 no 669 0.217171184267473 278 6710676 An epoxy ketone and protein crosslinker. SGTC_3180 9109287 49.47 µM 0.781219101838871 0.191410008384051 no 670 0.217336820403041 242 18891271 SGTC_190 3970-0790 3.722 µM 0.779379740643479 0.191967019026738 no 671 0.217878027187497 231 2832352 SGTC_2607 solasodine 47.35 µM 0.776238576196849 0.192920543407473 no 672 0.218804066431581 263 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1302 1159-0335 255 µM 0.774166323671659 0.193551172241159 no 673 0.219416220163703 230 649284 SGTC_2364 9055074 200 µM 0.772970688018178 0.193915599953276 no 674 0.219769864099831 233 6470630 SGTC_904 1141-0088 396 µM 0.772393659282744 0.194091626836353 no 675 0.219940654087116 255 1378119 SGTC_2831 7999036 19.48 µM 0.770529910933508 0.194660841682317 no 676 0.220492809607055 245 2988270 SGTC_2295 7971645 200 µM 0.769799351738547 0.194884241505658 no 677 0.22070946216165 232 2978226 YKL099C UTP11 SGTC_1332 1480-0653 17.5 µM 0.76771287273121 0.195523130004648 no 678 0.221328893370168 236 5749438 SGTC_1877 wortmannin 25 µM 0.767231142030716 0.195670818470418 no 679 0.221472050103453 250 312145 A covalent inhibitor of PI 3-kinase. SGTC_1354 1498-1681 81 µM 0.765064423381975 0.196335925595745 no 680 0.222116591681365 228 5754243 SGTC_2362 9071156 126 µM 0.76489039464222 0.196389405745958 no 681 0.222168407045215 250 653133 SGTC_605 1315-0399 119 µM 0.764275581451151 0.196578412476492 no 682 0.222351516915133 255 24020461 SGTC_662 k832-1615 104 µM 0.762687703676827 0.197067069701496 no 683 0.222824832793352 251 5878478 SGTC_2011 4012611 177 µM 0.762678190699366 0.197069999461014 no 684 0.222827670158177 245 2049887 SGTC_39 0986-0283 58.349 µM 0.762017922277722 0.197273410049973 no 685 0.223024653788676 221 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2995 9067767 71.4286 µM 0.76117013795401 0.197534775297401 no 686 0.223277726030573 226 11673567 SGTC_8 0354-0001 70 µM 0.760932820754291 0.197607975812508 no 687 0.223348596896439 243 4993152 SGTC_181 1447-1644 8.07 µM 0.760866209823932 0.197628524907634 no 688 0.223368491452193 265 534600 SGTC_1091 telmisartan 47.6 µM 0.758211231766664 0.198448621958778 no 689 0.224162269176053 255 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1554 st069299 38.7 µM 0.754820571644744 0.199498944395274 no 690 0.22517832443441 230 24207999 SGTC_2807 7945238 51.95 µM 0.752996490219954 0.200065370444414 no 691 0.225726011557632 253 17148797 SGTC_1299 1079-1439 3.74 µM 0.752801158475671 0.20012608342758 no 692 0.225784705264462 259 323161 SGTC_1105 epirubicin 18.1 µM 0.752634148543657 0.200178002210462 no 693 0.225834895616469 260 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1313 1220-0047 237 µM 0.752561761902039 0.200200507735856 no 694 0.22585665143847 250 3528706 SGTC_2096 5468907 200 µM 0.750135326732258 0.200955783276812 no 695 0.226586602500329 241 759785 SGTC_635 k038-0028 24.7 µM 0.749454749012882 0.201167933030029 no 696 0.226791581428353 256 4035102 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.749205572709738 0.20124563986683 no 697 0.226866655429673 257 165521 SGTC_537 1334-0398 209 µM 0.748295290605431 0.201529668671123 no 698 0.227141032245917 250 5846986 SGTC_83 0170-0301 39.027 µM 0.747734109816053 0.20170488950948 no 699 0.227310276266364 244 3089716 SGTC_653 0203-0016 55.2 µM 0.746313667385385 0.202148810338907 no 700 0.22773897857446 261 295302 SGTC_1330 1469-0054 61.8 µM 0.745776234540839 0.202316922737756 no 701 0.227901299230774 258 7102664 SGTC_1692 fluoroquinolonic acid 71 µM 0.745346893406298 0.202451283428568 no 702 0.228031019742839 255 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1119 parthenolide 318.541 nM 0.745045485369998 0.202545639804584 no 703 0.228122111537793 274 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1265 0819-1001 68.8 µM 0.744086387225356 0.202846062228 no 704 0.228412107106697 274 3106768 SGTC_131 0141-0277 33.849 µM 0.743947921964223 0.202889456273787 no 705 0.228453990951009 255 1547771 SGTC_1073 triclabendazole 3.09 µM 0.743690609101514 0.202970111053001 no 706 0.228531836025325 242 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1035 k081-0041 55.2 µM 0.742265609709867 0.203417124001727 no 707 0.228963211921608 253 731709 SGTC_2468 5987765 72.9 µM 0.741030064028501 0.203805181562738 no 708 0.229337605907048 238 26772094 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.738274100340551 0.204672357114689 no 709 0.23017395088292 269 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3119 9125183 49.47 µM 0.735720227422766 0.205477900133646 no 710 0.230950488596512 225 22695334 SGTC_869 0564-0080 44.1 µM 0.735580911079658 0.205521897400112 no 711 0.230992891540072 237 6843321 SGTC_919 tnp00227 403.569 nM 0.734729876996435 0.205790782504611 no 712 0.231252010407703 271 1269246 A methoxyflavone. YNL221C POP1 SGTC_1081 sertraline 6 µM 0.733142810242539 0.206292775142495 no 713 0.231735665930096 261 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_364 0083-0097 67.7 µM 0.730712337130347 0.207062944228355 no 714 0.232477439162475 253 5207356 SGTC_411 enrofloxacin 100 µM 0.73048994485268 0.20713350081232 no 715 0.2325453785054 241 71188 A bacterial gyrase inhibitor. SGTC_2127 5253358 187.912 µM 0.730079405061811 0.207263786775982 no 716 0.232670824640891 245 20612 SGTC_2020 4017018 200 µM 0.729658669887536 0.207397358541844 no 717 0.232799425134927 265 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.728802855252671 0.207669212968586 no 718 0.233061132382827 267 61125 An anti-inflammatory. SGTC_114 0364-0001 490.298 µM 0.726009664744993 0.208557949595118 no 719 0.233916422861843 265 4003655 SGTC_2343 7990716 14.84 µM 0.725298863874398 0.208784469450757 no 720 0.234134351295358 275 6456862 SGTC_3104 9120930 49.47 µM 0.72474811707009 0.208960082507243 no 721 0.234303285127617 262 17014836 SGTC_945 3381-0768 11.3 µM 0.722803889274987 0.209580721123394 no 722 0.234900188769881 272 1126236 YIL048W NEO1 SGTC_1137 ixabepilone 100 µM 0.719811123162203 0.210538191421462 no 723 0.235820647705348 259 154225 A novel microtubule stabilizer. SGTC_3181 9108277 49.47 µM 0.719261725046303 0.21071423784139 no 724 0.235989837050318 275 17097298 SGTC_1174 0739-0097 51.1 µM 0.718182061027135 0.211060451537124 no 725 0.236322518705374 266 728447 SGTC_2056 5235370 200 µM 0.716601309539823 0.21156794894761 no 726 0.236810068115318 256 5511916 SGTC_2091 4-phenylthiadiazole 200 µM 0.716402887167744 0.211631702519319 no 727 0.236871306352717 254 270010 SGTC_3316 9136639 10.545 µM 0.715578516779039 0.211896695038536 no 728 0.237125821420611 254 4903665 SGTC_1794 st048918 76.9 µM 0.714500332151364 0.212243568517095 no 729 0.237458925422557 225 672303 SGTC_1833 st055984 71 µM 0.713780979675679 0.212475183021933 no 730 0.237681311394824 255 676288 SGTC_107 0358-0022 2.6945 µM 0.713400387073606 0.212597784553262 no 731 0.237799016825039 281 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1238 0333-0287 48.8 µM 0.713064998881318 0.212705858479654 no 732 0.237902768434434 265 7226 SGTC_3100 9120536 49.47 µM 0.712703696775274 0.212822318668317 no 733 0.238014564222328 262 16421196 SGTC_2146 5545642 200 µM 0.711961991352532 0.213061512625371 no 734 0.238244156395545 255 825326 SGTC_889 0919-1524 82.7 µM 0.711613572330128 0.213173929041046 no 735 0.238352050084837 253 3905452 SGTC_399 oxolinic acid 75 µM 0.711097708167985 0.213340434669604 no 736 0.23851184504861 260 4628 A DNA gyrase inhibitor. SGTC_3207 9114163 49.47 µM 0.71017418523619 0.213638709738095 no 737 0.238798063505796 293 849233 SGTC_3306 9127676 59.7925 µM 0.710154992311338 0.213644911154115 no 738 0.238804013774085 263 41905287 SGTC_1041 0206-0046 107 µM 0.709810484179649 0.21375624283278 no 739 0.238910833372402 268 50494 SGTC_2331 7980721 200 µM 0.709512688878388 0.213852505957007 no 740 0.239003190051079 260 2981221 SGTC_999 SEC7.066 22.7 µM 0.708204146510064 0.214275794812663 no 741 0.239409245776082 273 740511 YDR170C SEC7 SGTC_2055 5235184 200 µM 0.706058711785385 0.214970856198862 no 742 0.240075813283901 290 2836034 SGTC_1993 st073995 70.8 µM 0.70592092507167 0.215015539976127 no 743 0.240118656940268 273 3098394 SGTC_1084 voriconazole 435 nM 0.704577190996443 0.215451591195769 no 744 0.24053669854184 288 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_762 1165-0429 115 µM 0.703787588715117 0.215708061823865 no 745 0.24078253202572 266 5967793 SGTC_1790 st045711 43.5 µM 0.703555467456056 0.215783490753003 no 746 0.240854826273058 227 585119 SGTC_286 k060-0067 22.9 µM 0.700457196076778 0.216791751979819 no 747 0.241820913796778 265 5985051 SGTC_247 mechlorethamine 29.705 µM 0.699666496159802 0.21704950273654 no 748 0.242067802263617 250 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1277 0873-0036 22 µM 0.699515463959469 0.217098756042369 no 749 0.242114976162881 274 5965735 SGTC_1579 chlormadinone acetate 49.4 µM 0.699357783504113 0.217150184308981 no 750 0.242164231918278 274 45114258 A steroidal progestin. SGTC_2038 4100038 30.985 µM 0.699034484957765 0.217255651748137 no 751 0.242265239950026 259 3596803 SGTC_1966 st070145 16.1 µM 0.698881352712224 0.217305617340683 no 752 0.242313090962555 278 3748532 SGTC_2704 st078022 71.1 µM 0.696628991087052 0.218041307767352 no 753 0.243017503921999 275 54697681 SGTC_3177 9107506 49.47 µM 0.696430490142264 0.218106213041227 no 754 0.243079636998867 263 8897194 SGTC_3353 9151644 39.2805 µM 0.695686264576385 0.218349656920835 no 755 0.243312664619815 255 4909158 SGTC_2917 7979103 53.79 µM 0.695258023433561 0.218489809946153 no 756 0.24344680772323 260 2980565 SGTC_2940 9060638 45.86 µM 0.694480029495375 0.218744561149668 no 757 0.243690610280059 260 4027022 SGTC_1512 0259-0544 12.2 µM 0.694455930982402 0.218752454846063 no 758 0.243698164215782 259 18476 SGTC_98 0074-0023 107.663 µM 0.693560361259556 0.219045923424894 no 759 0.243978979716783 270 3563821 SGTC_2316 5844804 197.44 µM 0.692243745869811 0.219477774980546 no 760 0.244392135377866 269 776813 SGTC_1247 0448-0043 5.84 µM 0.690583557620119 0.220023015461969 no 761 0.244913641631655 277 3089013 YGL099W LSG1 SGTC_2157 5649910 96.377 µM 0.689166609983491 0.2204889846893 no 762 0.245359213205081 276 2858091 SGTC_955 1216-0110 33 µM 0.688381175298514 0.220747521639905 no 763 0.245606387570154 280 3619719 SGTC_974 1326-0144 138 µM 0.687502837566611 0.221036844469713 no 764 0.245882956622746 284 5411856 SGTC_1395 3486-0190 4.35 µM 0.687384314886371 0.221075902233047 no 765 0.245920289578466 278 6748079 SGTC_725 1497-0963 19 µM 0.685995698294949 0.2215337986896 no 766 0.246357910523908 267 3549977 SGTC_1904 st060225 78 µM 0.685919007553044 0.221559103255873 no 767 0.246382091681487 251 66595 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.684282821032697 0.222099366194754 no 768 0.246898296332261 267 66535 A nucleotide analog. SGTC_3255 9139072 49.47 µM 0.682432573535705 0.222711216310503 no 769 0.247482732292054 275 17646060 SGTC_149 3970-0822 46.1 µM 0.682342548699179 0.222741010711328 no 770 0.247511187200328 275 3114250 YBL034C STU1 SGTC_1893 st059353 36.1 µM 0.682131776037821 0.222810776402831 no 771 0.24757781472738 302 3112488 SGTC_1720 st037298 9.481 µM 0.680435458704424 0.223372710112003 no 772 0.24811438772995 293 597396 SGTC_2808 7946468 45.46 µM 0.67879223918048 0.2239178223995 no 773 0.248634755928518 290 2970879 SGTC_1627 st003713 25.6 µM 0.67786717223646 0.224225031104864 no 774 0.248927957977851 277 16195070 YER133W GLC7 SGTC_2361 9034121 116 µM 0.676384817281882 0.224717810192207 no 775 0.249398177144728 308 6496917 SGTC_271 rotenone 740 µM 0.676364956794052 0.224724416578733 no 776 0.24940448031166 288 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1817 st052116 64.4 µM 0.676200206511214 0.224779223308191 no 777 0.249456770737459 269 4361398 SGTC_460 trequinsin 123 µM 0.676028700868094 0.224836285363705 no 778 0.249511211449629 296 5537 A vasodilator. SGTC_2906 7926292 26.41 µM 0.675565907380039 0.224990303473628 no 779 0.249658146607755 300 2966319 SGTC_2175 5807670 165.306 µM 0.674821681154583 0.225238108013538 no 780 0.249894531926326 247 241186 SGTC_3218 9131285 49.47 µM 0.673844922922778 0.225563573048525 no 781 0.250204955554048 288 17156417 SGTC_2473 5854593 8.94 µM 0.673449683321605 0.225695346203166 no 782 0.250330624782607 293 2872951 SGTC_3187 9109394 49.47 µM 0.672856366648792 0.225893240125827 no 783 0.250519336818951 271 17098090 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.6727712898052 0.225921624565453 no 784 0.250546402786623 271 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2592 piperlongumine 83.33 µM 0.672596635400817 0.225979901351386 no 785 0.25060197141469 286 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_207 4185-0010 4.486 µM 0.672196260250252 0.226113526251871 no 786 0.250729380742299 280 3761753 SGTC_2215 7188065 200 µM 0.671680151420845 0.226285843043784 no 787 0.250893669999464 279 940217 SGTC_1370 2001-0092 44.6 µM 0.671541015510565 0.226332309995692 no 788 0.250937969894412 281 790957 SGTC_860 0443-0016 25.1 µM 0.668839588927762 0.227235567735076 no 789 0.251798904935046 290 5337942 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.6684506444014 0.227365783583182 no 790 0.251922988474617 284 688788 SGTC_401 neomycin 50 µM 0.667603633658242 0.227649502135856 no 791 0.252193318816432 261 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2199 6590217 200 µM 0.667528867868494 0.227674555593012 no 792 0.252217188269834 255 703109 SGTC_850 0388-0143 75.9 µM 0.667229398495996 0.227774921098757 no 793 0.252312807711227 285 67273 SGTC_3214 9129694 49.47 µM 0.66694431549246 0.227870488223137 no 794 0.252403851392549 292 17158655 SGTC_849 0386-0493 241 µM 0.666499386923108 0.22801968474812 no 795 0.252545977706881 293 726119 SGTC_513 4245-1575 41.7 µM 0.665813176777411 0.228249897159558 no 796 0.252765260738144 273 719745 SGTC_2898 9056270 58.44 µM 0.665773168065539 0.228263323465335 no 797 0.252778048881224 240 19154699 SGTC_3312 9133330 71.43 µM 0.663450546803735 0.229043519839398 no 798 0.253521021031987 299 17617324 SGTC_3073 9114972 49.47 µM 0.662897261161553 0.229229595523196 no 799 0.253698177979063 260 41905075 SGTC_634 1611-4317 11.2 µM 0.662330854521361 0.229420171708002 no 800 0.253879603466212 296 2843522 SGTC_359 0081-0058 15.9 µM 0.662224614719042 0.229455927603457 no 801 0.253913640678075 298 3494159 SGTC_378 3970-0959 8.33 µM 0.661965546319806 0.229543132335296 no 802 0.253996651304926 296 6615653 SGTC_1988 st071872 53.4 µM 0.660479491395213 0.230043710261789 no 803 0.254473087585963 264 16414116 SGTC_3007 9078383 71.4286 µM 0.66032903277679 0.230094426312887 no 804 0.254521351427473 271 6496995 SGTC_3176 9106582 49.47 µM 0.658536931223235 0.230698982263302 no 805 0.255096587043997 252 17018027 SGTC_1813 st051246 8.6015 µM 0.657928625513468 0.23090439251196 no 806 0.255291997809056 266 5291959 SGTC_1961 st076550 68.7 µM 0.655516379293857 0.231719954802291 no 807 0.256067672128044 292 1579337 SGTC_2585 alliin 100 µM 0.655097884888081 0.231861607813661 no 808 0.256202366899502 303 87310 A garlic compound which reacts with lipids. SGTC_1427 4048-4900 550 nM 0.653068726674462 0.232549125711206 no 809 0.256855986280713 292 24132586 SGTC_1436 4092-1007 8.32 µM 0.652442170963261 0.23276164366609 no 810 0.257057983577348 260 2881121 SGTC_1264 0783-0040 158 µM 0.651314946980307 0.233144252112693 no 811 0.257421600842633 297 2855798 SGTC_2644 guaiazulene 100 µM 0.649588449171575 0.233730945648045 no 812 0.2579790481244 278 3515 A coloring agent. SGTC_2149 5554786 194.827 µM 0.648911189743275 0.233961313291434 no 813 0.258197890821582 290 745063 YPR165W RHO1 SGTC_1991 st073000 8.92 µM 0.64798197696105 0.234277586644754 no 814 0.258498303678162 302 4301969 YIL048W NEO1 SGTC_1045 1348-1485 165 µM 0.647259548076881 0.234523641017148 no 815 0.258731988691819 270 6810614 SGTC_1420 4'-methoxyflavone 42 µM 0.647167982637637 0.234554837788523 no 816 0.258761615289768 283 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1212 0520-0165 585 µM 0.643387367531106 0.235844912986395 no 817 0.259986389125713 326 5403258 SGTC_3292 9120825 59.784 µM 0.643302949836542 0.23587376376919 no 818 0.260013771293775 296 24824900 SGTC_1504 k297-0033 30 µM 0.643218429589715 0.235902651549408 no 819 0.260041188216001 246 4388117 SGTC_2837 9008476 45.46 µM 0.643135301745824 0.2359310653288 no 820 0.260068154920464 299 2992805 SGTC_1912 st060209 90.8 µM 0.642443019360292 0.236167766379966 no 821 0.260292787580637 304 688787 SGTC_2827 7993847 71.43 µM 0.642337701361058 0.236203787540029 no 822 0.260326970056682 269 2985692 SGTC_2802 7925815 54.55 µM 0.641042769041959 0.236646931195874 no 823 0.260747447971269 291 1262923 SGTC_1052 3253-3998 198 µM 0.640663980686928 0.236776644190377 no 824 0.26087051049612 269 5450317 SGTC_2696 st077691 74.316 µM 0.640161602661085 0.236948739764605 no 825 0.261033771482626 306 757133 SGTC_2531 methyl deoxycholate 70.07 µM 0.638294802028685 0.23758883659743 no 826 0.261640897506092 298 16667744 Haematoxylin. SGTC_348 k064-0012 10.7 µM 0.637751769179468 0.237775212099398 no 827 0.261817640102569 297 5066323 SGTC_962 1254-0300 21.5 µM 0.635927295285353 0.23840198072775 no 828 0.262411905511946 270 7340576 SGTC_308 4092-1169 104 µM 0.634773858840772 0.238798691543099 no 829 0.262787957437621 304 2268590 YDL196W YDL196W SGTC_2650 prasterone 100 µM 0.633956636102059 0.239079984049816 no 830 0.263054561195782 272 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_811 0416-0114 265 µM 0.633650844886356 0.239185285594323 no 831 0.263154355433284 304 6612453 SGTC_2109 5483026 200 µM 0.633121645228293 0.239367579412936 no 832 0.263327104174899 320 759335 SGTC_1619 st003326 88.7 µM 0.632736878777911 0.239500167842094 no 833 0.263452741359453 262 2849032 SGTC_841 0251-0215 91.2 µM 0.632046870165002 0.239738041465381 no 834 0.263678125399856 302 3888614 SGTC_113 0099-0221 2.5 µM 0.63175984341312 0.239837029043783 no 835 0.263771908621109 290 89219 SGTC_2543 pimpinellin 60.67 µM 0.631731196128246 0.239846909922601 no 836 0.263781269778501 287 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3000 9075062 71.4286 µM 0.629920398575734 0.240471931616879 no 837 0.264373333019501 273 17057871 SGTC_2125 5246583 200 µM 0.629328019875072 0.240676591661486 no 838 0.264567165496032 301 835267 SGTC_1920 st075728 45.7 µM 0.62903958197142 0.240776277957309 no 839 0.264661571546135 294 3400306 SGTC_2306 7482397 179.52 µM 0.626177539330771 0.241766637746057 no 840 0.265599248851919 316 891448 SGTC_1360 1598-0022 39.8 µM 0.626159520341929 0.241772879897262 no 841 0.26560515765975 314 761525 SGTC_2308 7584454 197.62 µM 0.625407969522889 0.242033310564004 no 842 0.265851666445576 305 893577 SGTC_1358 1509-0022 2.48 µM 0.625203196632135 0.242104295723275 no 843 0.265918852079559 305 3258434 SGTC_854 0422-0053 192 µM 0.624555846157159 0.242328776010521 no 844 0.2661313032314 309 3596728 SGTC_1564 D-Arginine 115 µM 0.624266689316964 0.242429082716346 no 845 0.266226228125412 309 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2772 vinpocetine 57.06 µM 0.621952507294724 0.243232667808156 no 846 0.266986548667675 328 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1204 4049-0315 18.3 µM 0.617930375784184 0.244632746885776 no 847 0.268310617368403 299 588402 SGTC_839 0122-0028 230 µM 0.617825029510256 0.244669475505665 no 848 0.268345341254487 317 759448 SGTC_1663 st014140 55.4 µM 0.617479543115823 0.244789948995653 no 849 0.268459235181837 300 4207120 SGTC_170 4197-0004 226 µM 0.616889518124178 0.244995768593982 no 850 0.268653800509224 311 218692 SGTC_2847 9005661 71.43 µM 0.616513838734063 0.245126866083611 no 851 0.268777720618365 279 2991449 SGTC_3189 9110682 49.47 µM 0.614735383826442 0.245747989362209 no 852 0.269364744081824 304 17122418 SGTC_606 k015-0008 38.6 µM 0.614038693773564 0.245991537687176 no 853 0.269594879143658 310 1970475 SGTC_159 3970-0959 50 µM 0.61293995395368 0.246375897251213 no 854 0.269958021906841 299 6615653 SGTC_2012 4023501 200 µM 0.612828054862003 0.246415059680656 no 855 0.269995019230003 331 3477460 SGTC_2286 7945697 125 µM 0.611728753414197 0.246799970367324 no 856 0.2703586173613 295 1245733 SGTC_1501 4491-0275 38.4 µM 0.609631452318774 0.247535213754165 no 857 0.271052985904991 304 5104718 SGTC_968 1309-0633 340 µM 0.607335444996148 0.248341456750218 no 858 0.271814160090194 300 3761976 SGTC_2311 7694451 200 µM 0.606995351903913 0.248460999364855 no 859 0.271926998403012 317 2163142 SGTC_929 2805-0021 398 µM 0.606574442853946 0.248608991214048 no 860 0.272066682620184 334 3098024 SGTC_417 st075190 100 µM 0.605584990033977 0.248957068207874 no 861 0.272395186028372 309 222757 SGTC_1175 0741-0056 27.6 µM 0.604677122003583 0.249276672715413 no 862 0.272696776087341 313 765927 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.604303765649987 0.249408171806992 no 863 0.272820851611985 305 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2812 7970281 58.44 µM 0.603084263020209 0.249837947146524 no 864 0.273226317428348 319 2233435 SGTC_2532 xanthone 78.9 µM 0.602544060883578 0.250028449970253 no 865 0.273406021670207 289 7020 An insecticide. SGTC_320 4092-0846 5.34 µM 0.602057240679841 0.250200193604538 no 866 0.273568017936428 303 1359356 SGTC_53 0973-0023 39.979 µM 0.600913881571546 0.25060380124704 no 867 0.273948673444129 328 674768 SGTC_3121 9125696 49.47 µM 0.600337216568244 0.250807495707627 no 868 0.274140760262187 333 1235365 SGTC_2611 pyromycin 23.93 µM 0.600216963504073 0.250849983548738 no 869 0.274180824878731 290 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2820 7989630 71.43 µM 0.599830120921086 0.250986688701219 no 870 0.274309728523459 265 2984098 SGTC_1529 apigenin 74 µM 0.598650332145206 0.251403854092932 no 871 0.274703042298476 311 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_765 1319-0117 244 µM 0.598089743104108 0.251602202979397 no 872 0.274890026886681 290 3487746 YGL099W LSG1 SGTC_3006 9075424 71.4286 µM 0.597929476102296 0.251658924205035 no 873 0.274943495504835 294 7465181 SGTC_2106 5357045 167.29 µM 0.595212619831078 0.252621492754213 no 874 0.275850677847545 304 668842 SGTC_1014 4130-3005 69.3 µM 0.593662924769511 0.253171409265574 no 875 0.276368792588624 307 743608 SGTC_1223 0764-0573 147 µM 0.593130594122101 0.25336045444706 no 876 0.276546878559484 299 1609797 SGTC_3273 9137859 49.47 µM 0.591462648064397 0.253953267878082 no 877 0.277105237484703 339 2377234 SGTC_1737 st035557 69.7 µM 0.591255398509882 0.254026978332712 no 878 0.277174654524176 312 5716916 SGTC_1717 st033143 58.0435 µM 0.59120661560711 0.254044330110141 no 879 0.277190995312174 326 674616 SGTC_1646 st011709 75.6 µM 0.590721038919074 0.254217080633994 no 880 0.277353674415626 298 5757843 SGTC_1413 3910-0535 34.4 µM 0.588896136128211 0.254866865016705 no 881 0.27796547494113 295 2876951 SGTC_2938 9059746 27.26 µM 0.588013334223253 0.255181511744423 no 882 0.278261671353666 315 6471769 SGTC_3049 9092223 49.47 µM 0.587810411426578 0.255253865838096 no 883 0.278329777459934 306 8623917 SGTC_2757 clomiphene 4.22 µM 0.586961244221036 0.255556760965492 no 884 0.278614867911198 329 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2176 5809774 33.9695 µM 0.586174665273892 0.255837498481886 no 885 0.278879072447629 296 2870539 SGTC_918 glabranin 770.725 nM 0.58530744359587 0.256147204621562 no 886 0.279170505345374 303 124049 Also referred to as licorice root. SGTC_2648 atorvastatin 78.68 µM 0.585191005734199 0.256188802321406 no 887 0.279209645968937 314 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2803 7707263 71.43 µM 0.584952424016746 0.25627404720248 no 888 0.279289853618542 311 2199229 SGTC_1405 3909-7894 12 µM 0.584855829392131 0.256308564518077 no 889 0.279322330488478 307 7104060 SGTC_1385 3091-4834 14.1 µM 0.581513002940597 0.257504588147823 no 890 0.280447378621913 314 4072814 SGTC_2669 eugenol 100 µM 0.580368977302928 0.25791457177941 no 891 0.280832910466646 294 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2499 avocadenofuran 51.48 µM 0.579922284932206 0.258074744481375 no 892 0.280983513451308 313 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2352 9027995 87.8 µM 0.577745106232091 0.258856164052227 no 893 0.281718110602436 310 2997347 SGTC_3334 9142812 21.919 µM 0.57704598464714 0.259107347887308 no 894 0.281954195933896 315 45283678 SGTC_2769 toremifene 3.73 µM 0.57550053774135 0.259663050493195 no 895 0.282476413540267 295 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2724 maprotiline 69.64 µM 0.572727421696358 0.260661731191324 no 896 0.283414633775726 326 4011 A tricyclic antidepressant. SGTC_980 1473-0395 201 µM 0.572258361751582 0.260830848741027 no 897 0.283573477043596 323 768876 SGTC_3012 9080433 71.4286 µM 0.570770136430892 0.261367795390943 no 898 0.284077734399894 335 17688859 SGTC_1151 3909-8316 15.3 µM 0.569512379828145 0.261822031958118 no 899 0.284504235878688 324 800431 SGTC_1830 st055982 50.3 µM 0.569405573521583 0.261860623510351 no 900 0.284540467660288 343 455313 An antimicrobial agent. SGTC_3272 9137413 49.47 µM 0.568598232366134 0.262152428605984 no 901 0.28481441234075 317 17614870 SGTC_603 3794-0023 45.9 µM 0.568389779014168 0.262227798966635 no 902 0.284885164569157 316 3802260 SGTC_3087 9117406 49.47 µM 0.568006995590957 0.262366230656755 no 903 0.285015108897288 292 42546093 SGTC_1798 st045719 60.953 µM 0.567453790599407 0.262566360549969 no 904 0.285202956532142 329 3980186 SGTC_534 k292-0788 63.4 µM 0.567320589032845 0.262614559808104 no 905 0.285248195592177 347 4146317 SGTC_773 4358-1457 44.6 µM 0.565744650871431 0.263185159710497 no 906 0.28578368859531 343 1186886 SGTC_2165 5727197 32.143 µM 0.563463187680986 0.264012329708692 no 907 0.286559760201956 331 1361712 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.562371240396577 0.264408695665067 no 908 0.286931554752683 321 2724278 An inhibitor of dopamine biosynthesis. SGTC_3302 9125395 16.351 µM 0.561979457690413 0.264550982669993 no 909 0.287065007607225 302 17599668 SGTC_2438 5259590 200 µM 0.56040706517842 0.26512243327636 no 910 0.287600906810217 332 1201127 SGTC_1976 st070609 63.5 µM 0.560159211868461 0.265212567140676 no 911 0.287685422732538 317 682556 SGTC_703 3875-0075 71.8 µM 0.559845507235678 0.265326670677255 no 912 0.287792410234753 341 2850814 SGTC_3034 9090421 49.47 µM 0.559821131066473 0.265335538045135 no 913 0.287800724400507 313 17173761 SGTC_708 3448-5400 146 µM 0.559757470200549 0.265358696795172 no 914 0.287822438232145 329 3462195 SGTC_1740 st038286 13.222 µM 0.558428913789716 0.265842237218134 no 915 0.288275766739254 296 716786 SGTC_2231 micatex 6.853 µM 0.557274260824793 0.266262846265547 no 916 0.288670029402962 328 20737 An antifungal of unknown mechanism. SGTC_1558 st069300 45.6 µM 0.555397593904998 0.266947183477614 no 917 0.289311368994598 318 24208000 SGTC_2545 solidagenone 89.61 µM 0.555316942382795 0.266976613409983 no 918 0.28933894616573 302 6708572 An anti ulcer agent SGTC_562 3772-2733 112 µM 0.553816009210569 0.267524606344226 no 919 0.289852385418609 319 2876874 YIL048W NEO1 SGTC_627 1391-0720 175 µM 0.553353099264338 0.26769372981455 no 920 0.290010823848966 362 997839 SGTC_2324 6149169 200 µM 0.55313727524411 0.267772599216957 no 921 0.290084706992329 327 2888231 SGTC_3124 9127567 49.47 µM 0.55211451728051 0.268146508725477 no 922 0.290434948132493 315 17592030 SGTC_3145 9085516 49.47 µM 0.551732182954062 0.268286353560455 no 923 0.290565928467348 329 25236195 SGTC_3103 9120822 49.47 µM 0.551176630206378 0.268489621142632 no 924 0.290756299322027 344 17141819 SGTC_1229 0139-0193 12.2 µM 0.550365149411355 0.268786667650448 no 925 0.291034473618178 327 3090752 SGTC_2277 7947813 106.88 µM 0.54922858924164 0.269202988372197 no 926 0.291424293470533 343 1246798 SGTC_408 cantharidin 100 µM 0.546774816455628 0.270102904266115 no 927 0.292266723316472 308 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1473 k844-0725 134 µM 0.54535173236348 0.27062550590409 no 928 0.292755815286258 323 54682906 SGTC_938 3126-1755 342 µM 0.545203760845125 0.270679874712731 no 929 0.2928066926125 311 1777771 SGTC_766 1391-0721 126 µM 0.545076050857508 0.270726803262134 no 930 0.292850606678527 349 1020919 YIL115C NUP159 SGTC_1254 0550-0035 264 µM 0.544809223177012 0.270824865365947 no 931 0.292942367303572 334 15121435 SGTC_1177 0983-0204 23.6 µM 0.542785393681335 0.271569221658872 no 932 0.293638785527186 329 766818 SGTC_2638 epoxomicin 18 µM 0.542710907596067 0.271596636765476 no 933 0.29366443148636 335 9915668 A protesome inhibitor. SGTC_2629 bisabolol 100 µM 0.540544718677566 0.272394519510453 no 934 0.294410715041273 363 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1719 st032227 49.2 µM 0.538905652037083 0.272999017566706 no 935 0.294975978537118 299 3125804 SGTC_2262 9014885 67.46 µM 0.538544374824637 0.273132348265344 no 936 0.295100639120113 324 6457424 SGTC_2222 6885208 172.143 µM 0.537036691213719 0.273689112600461 no 937 0.29562113490522 318 609514 SGTC_1820 st053765 18.6 µM 0.53621613434142 0.273992367371018 no 938 0.295904591984452 314 3690829 SGTC_1587 estradiol valerate 56.1 µM 0.533845535466664 0.274869405942035 no 939 0.296724203277088 352 13791 A steroid. SGTC_1591 genipin 88.4 µM 0.53317638237425 0.275117219318467 no 940 0.296955744367335 331 442424 A DNA cross-linking agent. SGTC_251 melphalan 456.522 µM 0.531854410159353 0.27560712013716 no 941 0.297413417430675 344 460612 A DNA alkylator. SGTC_424 splitomicin 100 mM 0.531671691083249 0.27567486650026 no 942 0.297476700977077 338 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1176 0848-0131 83.3 µM 0.531271488815941 0.275823277238491 no 943 0.297615329869506 332 6769040 SGTC_1398 3558-0053 112 µM 0.527917988098444 0.277068427714481 no 944 0.298778129563627 326 4532369 SGTC_901 1112-0062 60.1 µM 0.527775811055863 0.277121278594733 no 945 0.298827473917588 313 1908457 SGTC_3168 9103419 49.47 µM 0.527351300339093 0.277279109544126 no 946 0.298974827800401 334 16649256 SGTC_1147 3809-1045 12.3 µM 0.525498399884915 0.277968522900358 no 947 0.299618382679358 315 325925 SGTC_1895 st058434 18.3 µM 0.52462643959012 0.278293244568243 no 948 0.299921451545572 360 5393175 SGTC_400 oxethazaine 37.5 µM 0.52416843916318 0.278463879890481 no 949 0.300080695166956 334 4621 A local anesthetic. SGTC_1764 st044502 93.5 µM 0.522067480569245 0.279247277938132 no 950 0.300811673724373 316 8407 SGTC_1115 galangin 695.678 nM 0.521956797674596 0.279288578667866 no 951 0.300850205469012 355 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2269 7935389 174.42 µM 0.521114938156051 0.279602811151086 no 952 0.301143352639795 344 97605 SGTC_2580 diallyl disulphide 81.36 µM 0.52053465401516 0.279819507881447 no 953 0.301345490532999 313 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2767 sibutramine 71.45 µM 0.520368142964982 0.279881703492988 no 954 0.3014035047622 345 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1982 st072467 71.9 µM 0.519383546945754 0.280249609159564 no 955 0.30174665124327 333 3163533 SGTC_2534 helenine 20.12 µM 0.516614929713663 0.281285388687309 no 956 0.302712495801062 341 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2220 6782180 200 µM 0.515369191257742 0.281752039460502 no 957 0.303147528538379 324 833803 SGTC_2349 9023730 187.07 µM 0.512439434902955 0.282850988005521 no 958 0.30417174884464 335 4126287 SGTC_3178 9107506 49.47 µM 0.511062281134593 0.283368267264568 no 959 0.304653723292414 337 8897194 SGTC_2923 7992654 58.14 µM 0.509757323452453 0.283858846753568 no 960 0.305110743781118 304 2985126 SGTC_1792 st045773 43.6 µM 0.508038659968614 0.284505572444031 no 961 0.305713115673547 301 2919270 SGTC_3254 9136651 49.47 µM 0.504908667953138 0.2856851797433 no 962 0.306811492887773 350 16454030 SGTC_336 4111-0029 111 µM 0.50277813175557 0.286489448535673 no 963 0.307560135115535 354 3131175 SGTC_1883 5-benzylidenerhodanine 20 µM 0.502325056672529 0.286660620967812 no 964 0.307719443247854 325 1273210 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.501262962820331 0.287062071572168 no 965 0.308093033789218 340 676296 Flavone; oxidizing agent. SGTC_2986 9022445 71.43 µM 0.498230317759956 0.288209814849688 no 966 0.309160857885363 368 6459286 SGTC_1793 st048256 72.231 µM 0.497879029560793 0.288342904129687 no 967 0.309284654399266 340 672022 SGTC_2467 5474540 200 µM 0.496652065240918 0.288807979857269 no 968 0.309717215362717 317 5413519 SGTC_67 0335-0847 266 µM 0.496370177797186 0.288914877984312 no 969 0.309816630826514 375 4552207 YOR254C SEC63 SGTC_2207 7258803 200 µM 0.495550434222387 0.289225849139547 no 970 0.310105815273908 356 3666799 SGTC_2121 5257820 149.641 µM 0.494600619812864 0.289586359538246 no 971 0.310441032298544 322 791256 SGTC_301 4119-0100 24.5 µM 0.494597383305127 0.289587588343768 no 972 0.310442174825309 364 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_162 k030-0015 37.8 µM 0.491798238211432 0.290651255734544 no 973 0.311430991060183 374 1809920 YMR134W ERG29 SGTC_88 0180-0332 8.668 µM 0.491668849328261 0.290700467311989 no 974 0.311476731508732 324 3101745 SGTC_2071 5230951 39.92 µM 0.489542203378204 0.291509870526864 no 975 0.312228941688098 356 1799272 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.488634755189675 0.291855565701673 no 976 0.312550151375737 361 1273210 SGTC_2713 st079149 53.4 µM 0.488395943435881 0.291946573503596 no 977 0.31263470732547 332 3103253 SGTC_214 4373-3496 70 µM 0.483331607552584 0.293879624688067 no 978 0.314430150448294 347 3779166 SGTC_3253 9135987 49.47 µM 0.483124692903181 0.293958729497862 no 979 0.31450360105255 340 4182430 SGTC_135 0933-0004 26.348 µM 0.482836823648686 0.294068800151824 no 980 0.314605801152661 341 21230617 YGL099W LSG1 SGTC_831 k061-1017 217 µM 0.482723978326455 0.294111953264826 no 981 0.314645867672137 360 1240153 SGTC_2116 5511452 16.8835 µM 0.4813725883327 0.294628964739457 no 982 0.315125857591037 363 870744 SGTC_1281 0884-0031 11.8 µM 0.480919773266862 0.29480229534647 no 983 0.315286759422336 349 1548255 SGTC_1225 1216-0074 20.6 µM 0.480374204308624 0.295011193128191 no 984 0.315480666662945 338 4241466 SGTC_2495 cafestol 54.53 µM 0.478407340367007 0.295764868735708 no 985 0.316180155077736 355 16667697 An anti-infammatory. SGTC_2693 st077581 40.7 µM 0.476713839401731 0.296414503227244 no 986 0.316782953324519 352 25238761 SGTC_2305 7443522 69.23 µM 0.473427838326581 0.297676889968919 no 987 0.317953986381904 353 5415886 SGTC_2272 7805186 180 µM 0.473030263345621 0.297829793019393 no 988 0.318095794114179 378 2956062 YPR165W RHO1 SGTC_2111 5486399 200 µM 0.473002456922069 0.297840488410081 no 989 0.318105713155597 346 689674 SGTC_3179 9107801 49.47 µM 0.472551826871004 0.29801384199949 no 990 0.318266479022591 313 4818259 SGTC_1472 k841-0093 193 µM 0.46937795553186 0.299236103900309 no 991 0.319399751291588 357 X1472 SGTC_2443 5493264 126.67 µM 0.468535658059485 0.299560855239225 no 992 0.319700788672125 370 5340055 SGTC_1293 1000-1278 195 µM 0.46785212420255 0.299824511940283 no 993 0.319945171235795 368 678847 SGTC_2188 6126565 140.678 µM 0.467635573398984 0.299908063100643 no 994 0.320022610542453 349 874518 SGTC_625 k213-0058 121 µM 0.467445375941023 0.299981455118559 no 995 0.320090632271764 349 3655420 SGTC_571 k831-0106 44.2 µM 0.467224536827982 0.300066681111299 no 996 0.320169620191464 368 4783639 SGTC_87 0100-0052 35.5 µM 0.466891092570889 0.300195384309759 no 997 0.320288899236968 353 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2025 5147754 141 µM 0.466851061828219 0.300210837099886 no 998 0.320303220206887 344 315777 YLR208W SEC13 SGTC_2689 tacrolimus 100 µM 0.466145422651449 0.300483289122414 no 999 0.320555706047747 358 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_307 1501-1223 22.3 µM 0.465908530173969 0.300574779931086 no 1000 0.320640487538561 356 2830329 SGTC_1631 benzylvanillin 81.9 µM 0.465077758827771 0.300895733468235 no 1001 0.320937886372295 328 75506 SGTC_1378 2093-0007 380 nM 0.463319723090289 0.301575427946899 no 1002 0.321567605276956 391 3618014 SGTC_2866 9034245 58.44 µM 0.463029199900374 0.3016878169382 no 1003 0.321671718560777 368 6462273 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.462987887933597 0.301703800015486 no 1004 0.32168652445295 349 4330530 SGTC_1746 st038117 42 µM 0.46238843817626 0.30193576237369 no 1005 0.321901394507993 336 2898218 SGTC_3111 9122088 49.47 µM 0.461212585393888 0.302391001508185 no 1006 0.32232304658027 348 16876704 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.461163974661044 0.302409828097612 no 1007 0.322340482954529 340 688664 SGTC_1700 st030840 7.9285 µM 0.459108876327096 0.303206233344511 no 1008 0.323077991400195 371 5499307 SGTC_2878 9043973 25.97 µM 0.457243992243961 0.303929736039199 no 1009 0.323747840662991 359 6465167 SGTC_2359 9039622 200 µM 0.457018513286356 0.30401726527398 no 1010 0.323828869395507 368 6463596 SGTC_3043 9092303 49.47 µM 0.456603325346929 0.304178467496736 no 1011 0.323978094306398 328 25236084 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.453761977158491 0.305282679021388 no 1012 0.325000076665905 385 7104 SGTC_1996 st072960 66.8 µM 0.45345598432958 0.305401700690277 no 1013 0.32511021559677 358 1719405 SGTC_382 3229-0966 23.2 µM 0.453111761814697 0.305535617104448 no 1014 0.325234133171162 365 5722370 SGTC_1024 4507-0395 26 µM 0.452999290639558 0.305579378559654 no 1015 0.325274626157379 334 4201836 SGTC_1108 betulinic acid 729.144 nM 0.452911560776579 0.305613515335906 no 1016 0.325306212963702 330 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2676 harmalol 100 µM 0.452010622289449 0.305964179391351 no 1017 0.325630665060518 345 5459187 A monoamine oxidase inhibitor SGTC_2051 5263410 176 µM 0.451275534162537 0.306250422856465 no 1018 0.325895487909067 343 227584 SGTC_927 2425-1185 123 µM 0.451192481754105 0.306282770922578 no 1019 0.325925413896177 376 730375 SGTC_2123 5259487 200 µM 0.450161463715897 0.306684467601462 no 1020 0.326297010379886 367 2173474 SGTC_2787 5284540 71.43 µM 0.450046552379648 0.306729252798282 no 1021 0.326338437075689 363 736958 SGTC_2634 4'-methoxyflavone 100 µM 0.447421026366323 0.307753302415463 no 1022 0.327285548523632 351 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1925 st057770 10.1 µM 0.447311558033058 0.307796031619919 no 1023 0.327325061474183 335 5989122 SGTC_1747 st037496 66.6 µM 0.447017210126331 0.307910938521502 no 1024 0.327431316902299 348 723305 SGTC_6 0844-0013 19.835 µM 0.44533000269414 0.308569950110141 no 1025 0.328040644446457 370 1584900 SGTC_3266 9136860 49.47 µM 0.444586512072247 0.308860548443051 no 1026 0.328309298276924 371 4871271 YPR165W RHO1 SGTC_3282 9108498 15.4605 µM 0.443787929828881 0.309172813043894 no 1027 0.328597957912225 344 16459645 SGTC_192 3455-0609 60.9 µM 0.443682037847262 0.30921422968116 no 1028 0.32863624185776 333 3769639 SGTC_2825 7998094 58.44 µM 0.443600035826588 0.309246304105375 no 1029 0.328665889917103 369 2987815 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.443502738360896 0.309284363104445 no 1030 0.328701069486263 374 689007 SGTC_1490 4089-0339 670 nM 0.440851050933259 0.310322387214435 no 1031 0.329660416164706 366 742542 SGTC_1561 5-methoxyflavone 52.9 µM 0.439669976545746 0.310785215644841 no 1032 0.330088075340905 364 94525 SGTC_715 0868-0130 184 µM 0.438466726927119 0.311257041969783 no 1033 0.33052399244654 355 2876258 SGTC_2413 inermin 26.06 µM 0.437773400781946 0.311529054630793 no 1034 0.330775277350728 397 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.43770393374794 0.311556314307452 no 1035 0.3308004587653 379 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_297 0986-0032 24 µM 0.437481500616255 0.311643606618229 no 1036 0.330881094692472 367 2847425 SGTC_1489 4065-0444 182 µM 0.436820530091975 0.311903062281852 no 1037 0.331120754438659 382 2877968 SGTC_1136 pergolide 1.05886 µM 0.436477524021507 0.312037741805989 no 1038 0.331245151483108 367 47811 A dopamine receptor agonist. SGTC_1760 st045453 10.4495 µM 0.435755569722899 0.312321295447186 no 1039 0.331507041456466 388 3323419 YIL048W NEO1 SGTC_2162 5663267 200 µM 0.43465477514321 0.312753855779416 no 1040 0.331906514863755 386 6456493 SGTC_1059 3448-6867 171 µM 0.434157900695119 0.312949188537955 no 1041 0.332086891015054 354 3934407 SGTC_2271 7849410 118.62 µM 0.432957150108856 0.313421447915094 no 1042 0.332522949983481 381 972430 SGTC_2964 9083345 53.42 µM 0.431949303885669 0.313818073642507 no 1043 0.332889129763943 353 17741579 SGTC_664 1222-0054 14.9 µM 0.43151222119231 0.313990149208842 no 1044 0.333047984176983 351 6813991 SGTC_3054 9094397 49.47 µM 0.431478637917915 0.314003372319088 no 1045 0.333060191005028 378 2598354 SGTC_1513 0337-0559 19 µM 0.430212638495642 0.31450202219758 no 1046 0.333520484618856 349 775073 SGTC_2186 6124449 200 µM 0.429860977914637 0.31464059384621 no 1047 0.333648386329876 365 3834182 YLR033W RSC58 SGTC_1046 2001-0062 216 µM 0.429261400522336 0.314876917175614 no 1048 0.333866501910322 351 739778 SGTC_1753 st043925 64 µM 0.428090495023474 0.315338647940935 no 1049 0.334292618308957 358 670181 SGTC_507 nimesulide 162 µM 0.425338192582557 0.31642511657373 no 1050 0.33529507778417 374 4495 A COX2 inhibitor. SGTC_804 1595-0054 20.9 µM 0.422620607687919 0.317499437299488 no 1051 0.336286044360955 375 761523 Stimulates phospholipase C. SGTC_1404 3909-7820 48.3 µM 0.422045043611811 0.317727168152917 no 1052 0.336496069978062 361 23741373 SGTC_2083 5306046 65.942 µM 0.420580369614018 0.318307000074417 no 1053 0.337030765338238 340 539837 SGTC_41 0478-0632 82.643 µM 0.41869368622286 0.319054552497231 no 1054 0.33772000529191 404 3750424 SGTC_1805 st050013 60.3 µM 0.418446109202631 0.319152703601554 no 1055 0.337810490176124 376 4037144 SGTC_1618 st003135 44.5 µM 0.417395126676537 0.319569503287735 no 1056 0.338194709425712 392 1270615 SGTC_1683 st010134 710 nM 0.417355755159606 0.319585121716859 no 1057 0.338209106182695 359 3818134 SGTC_99 0109-0120 622.8 µM 0.41685544894917 0.319783617854321 no 1058 0.338392070884585 385 759414 SGTC_2396 5342950 42.78 µM 0.416009672180639 0.320119296571944 no 1059 0.338701462816489 375 1886677 SGTC_2641 levomentholum 100 µM 0.414829574354483 0.320587909434221 no 1060 0.339133333977184 375 16666 SGTC_2868 9035608 32.47 µM 0.413936302098572 0.320942815139951 no 1061 0.339460378475384 362 6462614 SGTC_1077 5-fluorocytosine 377 nM 0.412264531324746 0.321607465434862 no 1062 0.340072771381715 391 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_375 3970-0961 9.27 µM 0.412089200145576 0.321677205455013 no 1063 0.340137022120307 351 2898222 SGTC_2053 5265679 138 µM 0.411658875090242 0.321848398896088 no 1064 0.340294735954473 358 764595 SGTC_1797 st048695 56.8 µM 0.410436755590043 0.322334792954402 no 1065 0.340742794178112 389 592262 YIL048W NEO1 SGTC_406 estrone 100 µM 0.407505821935273 0.323502520668098 no 1066 0.341818259512362 390 5870 A steroid. SGTC_1158 4092-0494 91.8 µM 0.407418560351624 0.323537313719691 no 1067 0.341850298677471 376 1148199 SGTC_743 1275-0778 158 µM 0.406100004207455 0.324063237771682 no 1068 0.342334561332991 394 2849257 YMR203W TOM40 SGTC_792 4534-1957 155 µM 0.404352826664834 0.324760664413501 no 1069 0.342976642079218 365 1717904 SGTC_199 4063-0024 41.6 µM 0.403609334623751 0.325057633206826 no 1070 0.343250010155522 384 306215 SGTC_186 3455-3465 67.277 µM 0.403400883869777 0.325140913467086 no 1071 0.343326668318778 383 755278 SGTC_1133 3473-0247 50 µM 0.402827426591927 0.325370066223453 no 1072 0.343537591581663 356 711311 SGTC_218 alverine citrate 93.75 µM 0.402795131186928 0.325382973388871 no 1073 0.343549471601261 393 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1222 0366-0074 1.18 µM 0.402637412571075 0.325446010140824 no 1074 0.343607491370482 391 286520 SGTC_2210 7115885 190.385 µM 0.402331275484492 0.325568380828127 no 1075 0.343720120190899 385 2927039 SGTC_511 blebbistatin 171 µM 0.402155612121589 0.325638606379848 no 1076 0.343784753572759 380 3476986 A myosin inhibitor. SGTC_2874 9043904 71.43 µM 0.400663577773484 0.326235331434483 no 1077 0.344333914957475 372 4463428 SGTC_3313 9133968 57.047 µM 0.399722366449754 0.326611989093328 no 1078 0.344680508212356 381 1494643 SGTC_742 0kpi-0133 140 µM 0.398984888247016 0.326907239600123 no 1079 0.344952169580353 397 2728852 SGTC_293 4049-0273 38.5 µM 0.398423203176646 0.327132183792542 no 1080 0.345159128499951 361 1380311 SGTC_2126 5251174 33.877 µM 0.397260795206543 0.327597905507808 no 1081 0.345587577306701 362 790722 SGTC_598 3937-0236 20.2 µM 0.394847980701016 0.328565461819462 no 1082 0.346477541218059 389 1379313 SGTC_2178 5812956 200 µM 0.394128762571579 0.328854096462621 no 1083 0.346742988325336 350 5403383 SGTC_2325 6158266 200 µM 0.393747063747029 0.329007320269364 no 1084 0.346883895283612 353 3623240 SGTC_1674 st016616 23.6 µM 0.393704528536352 0.329024396785994 no 1085 0.346899598784672 361 625830 SGTC_2832 7992762 51.95 µM 0.392862791075861 0.329362400616165 no 1086 0.347210412449539 323 2985177 SGTC_3127 9126946 49.47 µM 0.392085097589777 0.329674811260913 no 1087 0.347497669085106 398 27243249 SGTC_3142 9086498 49.47 µM 0.391199523606718 0.330030703815705 no 1088 0.34782488020613 392 25236367 SGTC_1474 0330-0125 5.35 µM 0.390696981438358 0.330232732834224 no 1089 0.348010615172088 361 X1474 SGTC_2905 7799065 20.05 µM 0.390436568057919 0.330337442151844 no 1090 0.348106875912421 394 1296806 SGTC_2558 carylophyllene oxide 100 µM 0.390190897780732 0.330436235611493 no 1091 0.348197695897362 394 6708694 An oxygenated terpenoid and antifungal agent. SGTC_299 1273-0059 1.44 µM 0.389768072524089 0.330606297568465 no 1092 0.348354027350034 368 2848077 SGTC_2103 5378138 10 µM 0.388102004133302 0.331276736903885 no 1093 0.348970274443826 378 244142 SGTC_343 4130-2827 29.8 µM 0.387664512507946 0.33145287685372 no 1094 0.349132160432289 355 1118244 SGTC_2996 9066192 71.4286 µM 0.387386461917612 0.331564843102757 no 1095 0.349235062376742 355 6472854 SGTC_958 1222-0007 33 µM 0.387217692364648 0.331632811076182 no 1096 0.349297526615229 394 7312461 SGTC_2623 humulene 100 µM 0.386790468807351 0.331804890103503 no 1097 0.349455666946391 355 6187145 An anti-inflammatory. SGTC_3269 9137823 49.47 µM 0.386466498538201 0.331935403970492 no 1098 0.349575604643905 374 17682936 SGTC_2172 5754775 163.918 µM 0.386229026624166 0.332031084277901 no 1099 0.349663529147078 370 2263357 SGTC_1540 guanosine 70.6 µM 0.385878540109524 0.332172319546599 no 1100 0.349793312290715 402 6802 Guanosine is a purine nucleoside SGTC_587 k089-0003 57 µM 0.385697990178796 0.332245084912545 no 1101 0.34986017574452 386 9659696 SGTC_1423 4048-0112 5.59 µM 0.385473636921568 0.332335512739547 no 1102 0.349943267468519 388 X1423 SGTC_2568 diosmetin 100 µM 0.384856354998232 0.332584364761801 no 1103 0.350171921769843 400 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_718 1130-0073 349 µM 0.383805928941667 0.333008004795563 no 1104 0.350561146676701 392 6740020 SGTC_2480 5767542 37.17 µM 0.38196384340455 0.333751438083133 no 1105 0.351244091848592 393 2867358 SGTC_1298 1079-1278 263 µM 0.380569524191593 0.334314595257721 no 1106 0.351761349345979 388 2840950 SGTC_425 3825-7017 13.1 µM 0.379204436922033 0.334866307339792 no 1107 0.352268028504922 430 3397440 SGTC_1491 4138-0063 26.5 µM 0.379105767052632 0.334906199472651 no 1108 0.352304661956336 389 23883227 SGTC_2004 4023728 41.89 µM 0.376199400674361 0.336082074508547 no 1109 0.353384330469398 413 360084 YDR527W RBA50 SGTC_2502 avocadyne acetate 18.59 µM 0.376121042089901 0.33611379957399 no 1110 0.35341345581386 346 3952079 SGTC_2743 auranofin 4.32 µM 0.375252900201281 0.336465362530485 no 1111 0.353736195559419 353 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_461 N-acetylfarnesylcysteine 136 µM 0.375067793163156 0.336540342031356 no 1112 0.353805024414684 405 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2404 5161160 200 µM 0.375029128134242 0.336556004517885 no 1113 0.353819401941341 401 2831543 SGTC_2727 riluzole 51.77 µM 0.374341972380464 0.336834405856259 no 1114 0.354074954424339 392 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1165 k072-0275 30.3 µM 0.372992235950071 0.337381512161598 no 1115 0.354577111246045 374 6153523 YGL055W OLE1 SGTC_1638 st008370 60.6 µM 0.369969186052675 0.338608131132246 no 1116 0.355702724949181 346 24207134 SGTC_1486 3970-0793 4.53 µM 0.368938493183446 0.339026732856671 no 1117 0.356086785376267 407 2844330 SGTC_2093 5331342 194.4 µM 0.367934159941544 0.339434820257205 no 1118 0.356461164104186 408 33839 SGTC_1550 gossypolone 36.6 µM 0.367774384225496 0.339499758773371 no 1119 0.356520735417636 372 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2670 beta-carotene 100 µM 0.367122592672209 0.339764719329229 no 1120 0.356763787818842 359 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1573 oleylamine 1.06 µM 0.366743352248 0.339918921255517 no 1121 0.356905232957197 397 5356789 An amine of the fatty acid oleic acid. SGTC_3265 9137266 49.47 µM 0.366596025344845 0.339978832676329 no 1122 0.3569601867161 375 17224265 SGTC_2133 5320837 200 µM 0.365102846101944 0.340586271321233 no 1123 0.357517318232335 390 2841355 SGTC_2386 9075165 157.42 µM 0.363496354617038 0.341240268403982 no 1124 0.358117067782848 387 16452277 SGTC_1178 0988-0033 191 µM 0.363452718342992 0.341258039243943 no 1125 0.358133363354211 377 5392207 SGTC_443 clozapine 122 µM 0.362760447822983 0.341540012967399 no 1126 0.358391920066095 414 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_876 0720-0963 56.8 µM 0.362112371502778 0.341804065808847 no 1127 0.358634029503248 411 765861 SGTC_949 1165-0505 146 µM 0.362052601164926 0.341828422593998 no 1128 0.358656361469552 359 6244267 SGTC_2953 9074162 66.49 µM 0.361275499840001 0.342145156122914 no 1129 0.358946753473915 410 16451992 SGTC_1460 k062-0059 9.15 µM 0.360669194255521 0.342392353325479 no 1130 0.359173378109167 367 1373085 SGTC_2770 toltrazuril 17.5 µM 0.36020481659885 0.34258173068835 no 1131 0.359346986507396 379 68591 Kills coccidiodes. SGTC_2281 7943571 200 µM 0.357900717943515 0.343521947256238 no 1132 0.360208806711793 416 1244024 SGTC_156 3474-0145 5.642 µM 0.357405016757092 0.343724351247271 no 1133 0.360394310809072 397 2265471 SGTC_2813 7971799 71.43 µM 0.356503755314762 0.344092467770453 no 1134 0.360731670132853 387 2234054 SGTC_2709 st078560 56 µM 0.355767273812058 0.344393390362496 no 1135 0.36100742968969 409 17250903 SGTC_3022 9087993 49.47 µM 0.355108583701503 0.344662611263214 no 1136 0.361254123164271 398 17173644 SGTC_3297 9117502 71.43 µM 0.353859263128862 0.345173451692525 no 1137 0.361722178779394 365 7453720 SGTC_2147 5545932 89.7195 µM 0.353642252733743 0.345262214867356 no 1138 0.361803502433437 416 797404 SGTC_1386 3228-0095 33.8 µM 0.35358568444568 0.345285354240056 no 1139 0.361824702166578 410 870181 SGTC_1362 1611-0397 101 µM 0.353532915780809 0.345306939890581 no 1140 0.361844478321667 371 27816 SGTC_935 2996-0153 430 µM 0.35012303270136 0.346702857203 no 1141 0.363123182984948 397 23738523 SGTC_651 3253-0966 34.4 µM 0.350014192249023 0.346747448065629 no 1142 0.363164023333161 391 781462 SGTC_2267 7931562 200 µM 0.350010810430065 0.346748833597598 no 1143 0.363165292322527 371 934880 SGTC_1973 st070275 50.2 µM 0.346688526496398 0.348110961496586 no 1144 0.364412665391545 387 17118334 SGTC_585 0kpi-0023 191 µM 0.346681731385416 0.348113749491007 no 1145 0.364415218137328 405 64601 SGTC_2000 st075254 36.4 µM 0.346297229537591 0.34827152172823 no 1146 0.364559675237097 376 17234175 SGTC_2032 5185112 25.99 µM 0.344634338610629 0.348954156068246 no 1147 0.365184643550735 393 5718189 SGTC_2354 9060492 162 µM 0.343323066306483 0.349492792311745 no 1148 0.36567771490538 402 6471895 SGTC_2844 9010103 25.97 µM 0.343287118095794 0.349507563167842 no 1149 0.365691235466657 411 2480525 SGTC_1048 3161-0300 24.5 µM 0.342910671714185 0.349662255908469 no 1150 0.365832831569716 383 2165101 SGTC_1699 st031318 29.054 µM 0.342347294609735 0.349893810538901 no 1151 0.36604477372002 411 5340658 SGTC_865 0488-0499 301 µM 0.342075573146572 0.350005511228141 no 1152 0.366147009799175 399 9634651 SGTC_2569 tetrandrine 100 µM 0.341556894342004 0.350218768472012 no 1153 0.366342190754832 357 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2977 9011197 71.43 µM 0.341442765343811 0.350265699492179 no 1154 0.366385142606994 432 2704722 SGTC_2247 cerulenin 830 nM 0.340923265770406 0.350479351951638 no 1155 0.366580674699342 371 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_866 0495-0101 262 µM 0.339463869962048 0.351079804639181 no 1156 0.367130155237402 401 635694 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.339059255663797 0.351246344765275 no 1157 0.367282545770126 397 521171 SGTC_1848 st056003 16.4 µM 0.337513784083277 0.351882726950477 no 1158 0.367864811466636 397 146492 SGTC_2258 7960471 200 µM 0.336690561481223 0.352221876697506 no 1159 0.368175089614013 417 2974708 SGTC_306 1672-3436 11.6 µM 0.336413185026121 0.352336176235998 no 1160 0.36827965405165 418 6797378 SGTC_1772 st048439 82.2 µM 0.335828024509487 0.352577349225498 no 1161 0.368500277880792 377 2927068 YDL195W SEC31 SGTC_1944 st076371 56.9 µM 0.334188752438643 0.353253287970299 no 1162 0.369118565418276 406 24208455 SGTC_677 0929-0063 136 µM 0.333978826638084 0.353339882442214 no 1163 0.369197768056847 396 1539583 SGTC_225 nsc-122657 1.016 µM 0.333697140147972 0.353456090154989 no 1164 0.369304053919275 405 275685 SGTC_1826 st055655 41.6 µM 0.333453539785009 0.35355659672924 no 1165 0.369395977191977 392 676168 SGTC_3305 9127027 53.8275 µM 0.333247216478634 0.353641731226027 no 1166 0.369473839704766 390 41905295 SGTC_2023 5144124 124 µM 0.330923814330602 0.354600933401098 no 1167 0.370351016625026 414 2830192 SGTC_1874 staurosporine 7.6 µM 0.330892901953698 0.354613701617632 no 1168 0.37036269183685 414 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1856 st057054 55.7 µM 0.33037297906062 0.354828477870576 no 1169 0.37055907799275 415 1266018 SGTC_3224 9130643 49.47 µM 0.328951104831716 0.355416078964825 no 1170 0.371096322880877 378 17644395 SGTC_1669 st015249 58.4 µM 0.32883021754457 0.355466052499339 no 1171 0.3711420108741 413 722793 SGTC_566 0958-0068 16.5 µM 0.32791942307952 0.355842645200142 no 1172 0.37148629376676 391 6815365 SGTC_1141 3253-0389 52.6 µM 0.327814850154387 0.355885892728069 no 1173 0.371525829215777 427 5402031 SGTC_3095 9117207 49.47 µM 0.327396608711393 0.356058880592593 no 1174 0.371683965557607 409 17015229 SGTC_698 k064-0052 127 µM 0.326970323081725 0.356235226089718 no 1175 0.371845165675856 413 5088751 SGTC_292 k038-0015 474 µM 0.326505033061597 0.356427741991895 no 1176 0.372021140970522 385 46368540 SGTC_261 5-fluorouridine 15.376 µM 0.326438429625811 0.35645530246705 no 1177 0.372046332951672 374 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3191 9110352 49.47 µM 0.325079596796337 0.357017750429851 no 1178 0.372560415230052 391 17122424 SGTC_3147 9097027 49.47 µM 0.323524958976018 0.357661627272233 no 1179 0.37314885423564 417 25236841 SGTC_468 gf-109203x 121 µM 0.323387380923031 0.357718626856761 no 1180 0.373200942565741 406 2396 A protein kinase C inhibitor. SGTC_2086 5274770 176.623 µM 0.32296595848046 0.357893244970894 no 1181 0.373360511439172 395 689278 SGTC_1710 st031758 61.5 µM 0.322561523632486 0.358060852172237 no 1182 0.373513668494437 413 5394341 SGTC_2969 9091408 28.7 µM 0.322418884887218 0.358119971511918 no 1183 0.373567689700651 386 4286311 SGTC_3352 9151559 45.5865 µM 0.322088407536211 0.358256957203106 no 1184 0.373692860084997 381 17159339 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.321980117152677 0.358301848464047 no 1185 0.3737338786508 424 551469 SGTC_3222 9128301 49.47 µM 0.320671050527123 0.358844670560455 no 1186 0.374229843968367 416 4911358 SGTC_1032 k061-1018 98.7 µM 0.320464216111654 0.358930463353479 no 1187 0.374308226274069 400 4005393 SGTC_2786 7743617 45.45 µM 0.320382886773292 0.358964199877956 no 1188 0.374339048395403 389 583674 SGTC_3249 9135183 49.47 µM 0.319525816443964 0.359319791234548 no 1189 0.374663908949376 394 4902779 SGTC_1812 st052057 4.327 µM 0.318722895982195 0.359653026847193 no 1190 0.374968325477835 385 3645418 SGTC_1410 3909-8106 77.9 µM 0.317085500815216 0.360332924563349 no 1191 0.375589363167503 424 1039210 SGTC_1605 st000082 49.1 µM 0.315476513520351 0.361001456977775 no 1192 0.376199940393975 424 1114022 SGTC_2861 9024595 19.48 µM 0.315053204296473 0.361177412159107 no 1193 0.376360629010292 399 16482810 SGTC_2944 9067346 25.62 µM 0.314822787719151 0.361273200806772 no 1194 0.376448104389261 405 6473075 SGTC_1500 4488-1866 171 µM 0.313926818531897 0.361645755225598 no 1195 0.376788310520207 444 2900003 SGTC_575 k072-0246 11.9 µM 0.313766483970565 0.361712438051738 no 1196 0.376849200842218 414 6796779 SGTC_1981 st071826 47 µM 0.313535703090973 0.361808426734116 no 1197 0.376936849968907 386 11838600 SGTC_1684 st024538 14.6195 µM 0.313315311401438 0.361900102357872 no 1198 0.37702055926711 394 6732859 SGTC_108 0509-0257 621.132 µM 0.313267972991434 0.361919794598442 no 1199 0.37703854012348 393 536624 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.312453599802569 0.362258621790785 no 1200 0.377347910512785 395 5377381 SGTC_3125 9127534 49.47 µM 0.312361208806606 0.362297068707357 no 1201 0.377383013695463 404 1639235 SGTC_973 1325-0077 65.9 µM 0.30971927675382 0.363397049476202 no 1202 0.378387221197714 433 2835149 SGTC_1464 k208-0027 110 µM 0.307729762371459 0.36422613779749 no 1203 0.379143985435473 450 X1464 SGTC_191 3914-0123 66.505 µM 0.306512238725818 0.364733829054834 no 1204 0.379607331415732 429 3144412 SGTC_595 3909-8003 73.7 µM 0.306414735768783 0.364774496772742 no 1205 0.379644445043893 421 699517 SGTC_2067 5224629 34.075 µM 0.304649168863832 0.365511163686491 no 1206 0.380316683802183 397 2835000 SGTC_1791 st048313 56.1 µM 0.303697705727965 0.365908359126255 no 1207 0.380679103032082 415 1204976 SGTC_3077 9117319 49.47 µM 0.303650107152559 0.365928233288917 no 1208 0.38069723642912 416 17154678 SGTC_2828 7998861 71.43 µM 0.302394559294353 0.366452600636535 no 1209 0.381175650893286 427 2988188 SGTC_463 ikarugamyin 104 µM 0.298914643177337 0.367907254677471 no 1210 0.382502586995857 430 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1633 st005664 67.9 µM 0.298549067303678 0.368060180988721 no 1211 0.382642066120702 401 2063822 SGTC_365 0121-0052 13.6 µM 0.298373333845775 0.368133700585287 no 1212 0.382709119588292 384 3101739 SGTC_2959 9079155 11 µM 0.297556970557211 0.368475296449088 no 1213 0.383020660070274 437 16189457 SGTC_2788 5282734 71.43 µM 0.297466776619592 0.368513043230957 no 1214 0.383055084518748 415 743706 SGTC_909 3448-9333 149 µM 0.297162798185812 0.368640269634389 no 1215 0.383171111200441 406 3344074 SGTC_2854 9024559 71.43 µM 0.297082193688387 0.368674008063094 no 1216 0.383201879195401 407 3163529 SGTC_285 1486-1325 46 µM 0.296183857554258 0.369050090890157 no 1217 0.383544837943714 410 22310230 SGTC_3238 9133470 49.47 µM 0.296101267619137 0.369084672951635 no 1218 0.38357637297651 425 3534688 SGTC_532 1548-0774 215 µM 0.295678752004953 0.369261605281222 no 1219 0.383737712730355 431 5932993 SGTC_1548 st061468 90.8 µM 0.294064004523456 0.369938050669455 no 1220 0.384354497832173 437 390799 SGTC_3240 9133527 49.47 µM 0.29218878562738 0.370724117162151 no 1221 0.385071142737466 436 17617455 SGTC_1482 3346-2049 8.48 µM 0.291271638903893 0.371108769529449 no 1222 0.385421788201709 412 3826804 SGTC_1604 st002052 72.4 µM 0.290123081714615 0.371590657326832 no 1223 0.385861039092249 385 6254834 YHR062C RPP1 SGTC_1034 k072-0165 12.7 µM 0.289954121206593 0.371661563273925 no 1224 0.385925668224825 424 5835461 SGTC_776 4476-4378 112 µM 0.288979742837839 0.372070555678758 no 1225 0.38629843970393 428 2892008 SGTC_2420 aureobasidin a 50 nM 0.288417997710061 0.372306412157378 no 1226 0.386513396309593 374 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2695 st077686 51.995 µM 0.287632083203259 0.372636469637461 no 1227 0.386814191694062 384 2876092 SGTC_2007 4011539 71.82 µM 0.287159186216936 0.372835115452264 no 1228 0.386995217737931 410 45595301 SGTC_795 0685-0265 78 µM 0.285842610595798 0.373388336175337 no 1229 0.38749933526849 415 302754 SGTC_910 3454-3003 490 µM 0.285048891967378 0.373721980333609 no 1230 0.387803342299784 442 820824 SGTC_2390 9097792 176.6 µM 0.285006142221344 0.373739953122076 no 1231 0.387819718095581 401 4497149 SGTC_847 0342-0274 5.54 µM 0.284754855522427 0.373845604273887 no 1232 0.387915980469886 438 18097 SGTC_2785 7756463 72.73 µM 0.28472657213632 0.373857496353766 no 1233 0.387926815640686 430 2201551 SGTC_3055 9094636 49.47 µM 0.284225116570167 0.374068359128315 no 1234 0.388118934301412 431 25236176 SGTC_1492 4158-0558 28.5 µM 0.282943266918691 0.374607549882105 no 1235 0.388610163471779 434 3967268 SGTC_2205 7238770 200 µM 0.282761017689162 0.374684230214992 no 1236 0.388680019329363 431 279867 SGTC_3080 9117754 49.47 µM 0.282539332459342 0.374777509701624 no 1237 0.388764995799496 419 9550191 SGTC_2148 5546263 113.568 µM 0.282249101910395 0.374899642383723 no 1238 0.38887625513366 403 792097 SGTC_1269 0831-0796 3.05 µM 0.281706442221017 0.375128034090839 no 1239 0.389084307149362 437 927758 SGTC_2760 etidronate 98.04 µM 0.281413946666692 0.375251156222252 no 1240 0.389196461141824 415 3305 A chelator and antioxidant. SGTC_655 k060-0012 42 µM 0.280552679079109 0.375613769182515 no 1241 0.389526757686241 441 5994525 SGTC_2857 9024691 58.44 µM 0.279049959616637 0.376246710753845 no 1242 0.390103242335301 436 16478292 SGTC_1444 4112-3581 28 µM 0.279041036119582 0.376250470303988 no 1243 0.390106666358344 414 2877249 SGTC_570 0987-0065 62.6 µM 0.275825153543817 0.377606112787938 no 1244 0.39134118156295 445 3104428 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.275459557683514 0.377760324110762 no 1245 0.391481596324321 389 2724 A muscle relaxant with antifungal properties. SGTC_1880 MG-132 525 µM 0.275152700871545 0.377889773864461 no 1246 0.391599462038267 444 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_552 k242-0005 476 µM 0.274631208475821 0.378109800632056 no 1247 0.391799793510486 449 4088318 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.272735665917911 0.378909895779387 no 1248 0.392528208118932 421 616764 SGTC_2856 9022925 19.48 µM 0.271286483128534 0.37952193599226 no 1249 0.393085350849811 408 4944862 SGTC_3091 9116372 49.47 µM 0.270460479595427 0.379870921197954 no 1250 0.393403008512311 394 17169793 SGTC_3157 9099274 49.47 µM 0.270205929548998 0.379978487933708 no 1251 0.393500915596293 451 17217662 SGTC_1231 0242-0792 125 µM 0.269661300755481 0.380208666158817 no 1252 0.393710417709629 440 3707635 SGTC_2166 5933061 31.504 µM 0.268794054898431 0.38057528062303 no 1253 0.394044084271042 416 2877375 SGTC_2435 5706476 10.6 µM 0.267622089109525 0.381070881008491 no 1254 0.394495113166903 420 5725375 SGTC_758 0868-0029 16 µM 0.267128113174639 0.38127983184637 no 1255 0.394685261322803 407 762687 SGTC_118 0083-0097 135.343 µM 0.266475471719886 0.381555950950828 no 1256 0.394936523709057 428 5207356 SGTC_714 4296-0578 26.1 µM 0.266454737508375 0.381564724155797 no 1257 0.394944506951952 425 1589775 SGTC_823 0417-1665 178 µM 0.266025420318041 0.38174639352293 no 1258 0.395109815809321 442 3429856 SGTC_1361 1608-0041 5.61 µM 0.265731161479135 0.38187092680212 no 1259 0.395223131269829 433 X1361 SGTC_1531 st059297 52.4 µM 0.265671793522071 0.381896053396902 no 1260 0.395245994214573 413 7566702 SGTC_1196 1588-0294 184 µM 0.265355657800905 0.382029861461752 no 1261 0.395367745986103 448 6144269 SGTC_2606 farnesol 9.78 µM 0.26524298048091 0.382077556835478 no 1262 0.395411143309245 437 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1751 st044839 27.194 µM 0.264705769180185 0.382304978512111 no 1263 0.395618066413398 414 5291326 SGTC_2041 5107442 45.335 µM 0.263851751081701 0.382666599937654 no 1264 0.395947077745144 421 793005 SGTC_1224 0823-0416 294 µM 0.261987163580234 0.383456487328345 no 1265 0.396665669312798 430 3598164 SGTC_706 4262-0057 46.9 µM 0.261538011351763 0.38364683236179 no 1266 0.396838820218584 426 883298 SGTC_3160 9100216 49.47 µM 0.259766932138699 0.384397666596841 no 1267 0.397521779919051 445 17191039 SGTC_2024 5144227 134 µM 0.257869382182583 0.385202598545405 no 1268 0.398253857683449 423 3475211 SGTC_2697 mebhydrolin 72.4 µM 0.257252027731751 0.385464584316955 no 1269 0.398492111372691 423 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3048 9093155 49.47 µM 0.256715215967457 0.385692432802485 no 1270 0.398699312233663 445 25236002 SGTC_2524 avocatin b 10.57 µM 0.253939536520096 0.38687119108022 no 1271 0.399771134974523 453 6710748 SGTC_1422 4031-0024 15.5 µM 0.252428392293216 0.387513374156816 no 1272 0.400354978334028 459 782427 SGTC_1186 1319-0216 26 µM 0.252199476095773 0.387610682374563 no 1273 0.40044344150256 423 4565136 SGTC_2255 7941087 197.44 µM 0.25129868391783 0.387993661658989 no 1274 0.400791596302881 441 935561 SGTC_1901 st060216 58.6 µM 0.251032317324508 0.38810693052236 no 1275 0.400894561695732 414 688792 SGTC_3039 9090270 49.47 µM 0.250114368610443 0.388497348918556 no 1276 0.401249452254156 442 17173750 SGTC_482 fipronil 114 µM 0.249981863367865 0.388553714851131 no 1277 0.401300687190368 422 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1373 2887-0003 58.5 µM 0.249744081708314 0.388654869826749 no 1278 0.401392632925529 416 776948 SGTC_316 k060-0003 58.6 µM 0.249384104506804 0.388808022517728 no 1279 0.401531839787681 435 6152314 SGTC_1985 st071382 65.5 µM 0.248029733715363 0.389384395690833 no 1280 0.402055700636932 427 6123237 SGTC_3024 9090631 49.47 µM 0.247839879833935 0.389465210391848 no 1281 0.402129148834472 438 25236383 SGTC_3042 9091578 49.47 µM 0.244241168245792 0.390997966727181 no 1282 0.403522022334275 413 25236497 SGTC_2593 nobiletin 86.24 µM 0.243619196620679 0.391263048115747 no 1283 0.403762879710303 402 72344 An anti-infammatory. SGTC_2100 5377183 190 µM 0.242727246990072 0.391643281000433 no 1284 0.404108349254975 436 2844202 SGTC_868 0527-0199 213 µM 0.242164059337753 0.391883417938332 no 1285 0.404326521395678 436 2849450 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.241875630062743 0.392006416922921 no 1286 0.404438266963318 439 5106787 A p450 inhibitor. SGTC_3323 9138564 53.9225 µM 0.241496450497264 0.392168132259592 no 1287 0.404585183591483 406 43912313 YNL103W MET4 SGTC_132 0417-1715 25.805 µM 0.241306854434241 0.392248999593388 no 1288 0.404658649385579 462 6769098 SGTC_730 1436-0052 41.2 µM 0.241249792707792 0.392273338719257 no 1289 0.404680760656037 416 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_521 r062-0005 13.8 µM 0.240036952362758 0.392790763534226 no 1290 0.405150805015948 427 2832033 SGTC_1455 4262-0120 131 µM 0.2393766373785 0.39307254841034 no 1291 0.405406772071249 409 1529587 SGTC_78 0336-0123 156.75 µM 0.239046107604081 0.393213620771714 no 1292 0.405534915114632 416 6765896 SGTC_2708 st078559 56 µM 0.237390067636809 0.393920640709684 no 1293 0.40617709720919 451 17250902 SGTC_646 4092-0839 27.3 µM 0.236522479541059 0.394291183432264 no 1294 0.406513632950172 460 877796 SGTC_2734 clemastine 41.6 µM 0.235978140807704 0.394523716773529 no 1295 0.406724816165395 460 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3170 9103054 49.47 µM 0.235563425410852 0.394700902203148 no 1296 0.406885728550215 450 16432970 SGTC_1355 1499-0035 1.68 µM 0.23412835147086 0.395314199474826 no 1297 0.407442668120734 441 1548538 SGTC_1841 st054148 70 µM 0.234115439467754 0.395319718764776 no 1298 0.407447680006717 448 675442 SGTC_2469 5655019 90.81 µM 0.234040734724882 0.395351652033001 no 1299 0.407476677482189 463 2788239 SGTC_1443 4112-3303 14 µM 0.232800039480405 0.395882101863717 no 1300 0.407958341132775 449 704433 SGTC_1803 st050068 52.4 µM 0.232561374182194 0.395984163550046 no 1301 0.408051011935098 451 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1671 st016596 74.5 µM 0.232534788643548 0.395995532904143 no 1302 0.408061335091536 436 2829167 SGTC_1198 1612-1005 86.7 µM 0.231865527392791 0.396281772822386 no 1303 0.408321230034985 434 6998509 SGTC_1721 st082152 9.2685 µM 0.2316267854196 0.396383895191864 no 1304 0.408413950728873 418 5296051 SGTC_1111 tnp00062 510.699 nM 0.231428232063737 0.396468832213078 no 1305 0.408491067195359 426 676306 SGTC_1200 1643-0193 18.4 µM 0.229651680380383 0.397229022511829 no 1306 0.409181222405416 457 5403974 SGTC_2819 7996655 46.38 µM 0.227954222793351 0.397955733229347 no 1307 0.409840914254899 472 6456960 SGTC_2228 7354201 200 µM 0.227900763612528 0.397978625787727 no 1308 0.409861694533298 455 753451 SGTC_1524 corynanthine 62.1 µM 0.227447482457173 0.398172746223706 no 1309 0.41003790097828 443 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3349 9149703 23.001 µM 0.22720780694766 0.3982753989217 no 1310 0.410131078685514 432 4910494 SGTC_2746 daunorubicin 9.88 µM 0.227130012648832 0.398308719628929 no 1311 0.41016132356081 455 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_216 k038-0035 28.382 µM 0.225033381397949 0.399207023301178 no 1312 0.410976652791368 439 4444231 YPR107C YTH1 SGTC_126 0417-1624 672.48 µM 0.224984209447656 0.399228097497597 no 1313 0.41099577920577 472 41912 YDL195W SEC31 SGTC_345 1362-0200 395 µM 0.224768746674487 0.399320444354179 no 1314 0.41107959025893 419 1419823 SGTC_1509 1326-1131 80 µM 0.224742283393732 0.399331786844951 no 1315 0.41108988426804 443 768313 SGTC_2942 9052777 62.25 µM 0.224679625479745 0.399358643143806 no 1316 0.411114257950295 465 6469503 SGTC_2221 6807166 181.081 µM 0.2245327280108 0.399421607884549 no 1317 0.41117140183338 443 674925 SGTC_2806 7952793 58.44 µM 0.224073548985061 0.399618442899629 no 1318 0.411350037022716 424 2972490 SGTC_2022 5136654 200 µM 0.221718045575687 0.400628570222173 no 1319 0.41226669069337 459 1713771 SGTC_756 0508-1999 28.3 µM 0.221670978015413 0.400648761337701 no 1320 0.412285012120579 425 6753853 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.221349084840757 0.400786854687567 no 1321 0.41241031675533 422 688761 SGTC_1239 0337-0584 35.4 µM 0.220565708765858 0.401122977664021 no 1322 0.412715301951278 453 914301 YML130C ERO1 SGTC_3097 9117246 49.47 µM 0.219931454987509 0.401395170409447 no 1323 0.412962269238533 440 16423892 SGTC_2915 7971052 15.16 µM 0.218867586676349 0.401851841481088 no 1324 0.413376598196002 471 5741558 SGTC_361 000s-0510 1.45 µM 0.21862768910207 0.401954837320612 no 1325 0.413470040881441 420 660 SGTC_3129 9127257 49.47 µM 0.21833794356733 0.402079243590631 no 1326 0.41358290641756 452 837894 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.218087050755505 0.402186975919572 no 1327 0.413680643292755 449 5024745 SGTC_582 0987-0078 156 µM 0.216787026359377 0.40274531981644 no 1328 0.414187161503111 468 1625765 SGTC_2740 felodipine 17.08 µM 0.216734204846002 0.40276801018492 no 1329 0.414207744954915 464 3333 L-type calcium channel blocker SGTC_3038 9091290 49.47 µM 0.216623501784171 0.402815565607303 no 1330 0.414250884413976 473 25236843 SGTC_3278 9139605 49.47 µM 0.213479757665469 0.404166641479326 no 1331 0.415476388130196 440 7958859 SGTC_2381 9035592 200 µM 0.213126408920012 0.404318570736044 no 1332 0.415614183240764 440 4749657 SGTC_3116 9124943 49.47 µM 0.212942984542738 0.404397443353212 no 1333 0.415685717182314 443 41905195 YPL160W CDC60 SGTC_934 2950-0684 338 µM 0.212074690569396 0.40477086308151 no 1334 0.41602438230148 473 1121253 SGTC_237 nikkomycin 200 µM 0.21120781563335 0.405143759069877 no 1335 0.416362556162237 462 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2134 5324836 1.464 µM 0.210124299919902 0.405609966600014 no 1336 0.416785330116642 475 699272 SGTC_1325 1431-0015 227 µM 0.208403531412933 0.406350641784772 no 1337 0.417456949597901 430 1103340 SGTC_1284 0929-0043 16 µM 0.208087326538197 0.406486783269106 no 1338 0.417580391266412 451 1239883 SGTC_1678 st019265 80.2 µM 0.20804789452137 0.406503761451645 no 1339 0.417595785507707 452 5367020 SGTC_3139 9095020 49.47 µM 0.207977587807889 0.406534033740671 no 1340 0.417623233529739 476 25236292 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.20734886529061 0.406804770535748 no 1341 0.417868707141462 466 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_855 0428-0020 25 µM 0.206067516211186 0.407356675319423 no 1342 0.418369086252616 431 6812414 SGTC_2206 7254556 146.969 µM 0.202413746689912 0.408931439607092 no 1343 0.419796641260485 451 4398905 SGTC_2233 sulbentine 40.3845 µM 0.201634228173599 0.409267601150922 no 1344 0.420101342282168 452 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_440 fluspirilene 35.1 µM 0.201497317875399 0.409326649591985 no 1345 0.420154863225387 454 3396 An atypical antipsychotic. SGTC_2657 nystatin 74.44 µM 0.201352651295334 0.409389045497838 no 1346 0.420211417856908 437 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1722 st034304 3.6505 µM 0.201350792493673 0.40938984722948 no 1347 0.420212144530575 456 4036148 YLR033W RSC58 SGTC_661 1304-0007 33.6 µM 0.200266074742448 0.409857768315446 no 1348 0.420636246746407 452 3117130 SGTC_565 1418-0001 44.5 µM 0.19965445902454 0.410121661245849 no 1349 0.420875416501232 434 2862145 SGTC_1520 flindersine 88 µM 0.198436167252857 0.410647436990848 no 1350 0.421351911324264 460 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_983 1491-0821 12.2 µM 0.197849317083952 0.410900760119003 no 1351 0.421581479653999 436 46495113 SGTC_1539 benzyladenosine 56 µM 0.196962163232353 0.411283784593034 no 1352 0.421928573551407 421 92208 A nucleotide analog. SGTC_931 2812-0076 566 µM 0.194863204903979 0.412190336062548 no 1353 0.422750020097685 479 3450959 SGTC_1736 st036774 51 µM 0.192567115670344 0.413182566169344 no 1354 0.42364900037451 468 1272247 SGTC_1030 k029-0042 36.7 µM 0.192298985573514 0.413298471985992 no 1355 0.423754006482845 427 6080581 SGTC_1407 3909-7909 12.3 µM 0.191642220649637 0.413582406650719 no 1356 0.424011234069804 464 4411780 SGTC_1066 ketoconazole 628 nM 0.1910743424352 0.41382794997357 no 1357 0.424233674523605 477 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2618 avocadyne 43.43 µM 0.188736369693559 0.414839213589822 no 1358 0.425149722471576 460 3015189 SGTC_441 propafenone 146 µM 0.187553867588493 0.415350906900171 no 1359 0.425613196346348 479 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3162 9099653 49.47 µM 0.187362844167222 0.415433580211331 no 1360 0.425688076373346 471 25237511 SGTC_1795 st049545 62.3 µM 0.186477200636404 0.415816928056102 no 1361 0.426035278261879 447 5291882 SGTC_3328 9140624 29.0385 µM 0.185688428969921 0.416158412705496 no 1362 0.426344551427546 475 4904392 SGTC_117 lucigenin 22.078 µM 0.185179381501407 0.416378829369669 no 1363 0.426544170289932 463 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.185047526094293 0.416435926821467 no 1364 0.426595879395659 442 3256 An antibiotic and ribosome inhibitor. SGTC_3141 9094609 49.47 µM 0.184745130139153 0.416566880239671 no 1365 0.426714473337587 467 25236309 YDL196W YDL196W SGTC_1234 0326-0494 15.5 µM 0.183883268399659 0.41694016264807 no 1366 0.427052515435461 475 1547813 SGTC_948 3448-0295 75.3 µM 0.183736437912073 0.417003764126757 no 1367 0.427110111095055 434 678569 SGTC_3117 9124945 49.47 µM 0.183355925020026 0.417168598192673 no 1368 0.42725937813544 437 17592065 SGTC_2598 perillyl alcohol 100 µM 0.182351211624996 0.417603899062983 no 1369 0.427653555634533 448 10819 An apoptosis inducer. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.181693226266306 0.417889031736817 no 1370 0.427911741074192 479 1241132 A phosphatase inhibitor. SGTC_2777 climbazole 1.536 µM 0.181344221509404 0.418040287677515 no 1371 0.428048698825072 483 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2073 5212005 126 µM 0.181247451741208 0.418082229088318 no 1372 0.428086675114771 483 691789 SGTC_1953 st076800 12.1 µM 0.180833866181018 0.4182614935183 no 1373 0.428248989971641 438 297591 SGTC_1033 k072-0102 21.3 µM 0.180269994864521 0.418505925122027 no 1374 0.428470305191041 472 5965931 SGTC_1502 4534-4282 27.7 µM 0.179919317124112 0.418657955688784 no 1375 0.428607954897975 481 3278949 SGTC_2394 5221648 200 µM 0.179476319734388 0.418850027287836 no 1376 0.42878185476969 462 788586 SGTC_470 aa-861 153 µM 0.179290982591147 0.418930390166162 no 1377 0.428854613491092 469 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_531 3788-1495 174 µM 0.178182465653524 0.419411117766797 no 1378 0.42928983987464 441 2896655 SGTC_885 0865-0106 16.8 µM 0.176577705270461 0.420107262929732 no 1379 0.429920053749631 475 2793380 SGTC_1534 6-azauridine 81.6 µM 0.176493743778771 0.420143692332175 no 1380 0.429953031638313 476 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1677 st019204 53.9 µM 0.176102322760156 0.420313531995798 no 1381 0.430106778072936 427 3945625 SGTC_1037 k284-1091 78.7 µM 0.175990626036211 0.42036200052153 no 1382 0.430150653423083 470 3334711 SGTC_1139 k015-0024 46.9 µM 0.175745961648971 0.420468171883854 no 1383 0.430246762528361 471 2766652 SGTC_23 0213-0011 39.996 µM 0.174661151150893 0.420938991683948 no 1384 0.430672947676012 453 627608 SGTC_427 1354-0053 47.3 µM 0.173247841340423 0.421552553395142 no 1385 0.431228310100983 448 6813657 SGTC_3215 9129942 49.47 µM 0.172736315769448 0.421774669575671 no 1386 0.431429348494607 497 17682944 SGTC_898 1000-0849 28.3 µM 0.171297859062566 0.422399413778654 no 1387 0.431994781902374 479 6751807 SGTC_984 1492-0255 2.91 µM 0.170147942223755 0.422898981143236 no 1388 0.43244689536126 484 1585198 SGTC_450 aminopyrene 156 nM 0.169392591278153 0.423227201697387 no 1389 0.432743925301269 476 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.168716838688739 0.423520879766644 no 1390 0.433009686648989 462 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1312 1218-2183 165 µM 0.168471083742856 0.423627693953928 no 1391 0.433106345172088 477 6744073 SGTC_1346 1488-2224 62.4 µM 0.167985500778632 0.423838762759116 no 1392 0.433297342843289 464 3722427 SGTC_2999 9069765 71.4286 µM 0.16728638801944 0.424142685124326 no 1393 0.433572357003031 483 2097066 SGTC_2966 9084041 48.03 µM 0.167264790866886 0.424152074683454 no 1394 0.433580853316714 433 17741380 SGTC_1774 st048371 48.465 µM 0.166602743297179 0.424439926768195 no 1395 0.433841317515396 478 4242727 SGTC_551 k048-0028 34.9 µM 0.166494572062094 0.424486962443255 no 1396 0.433883877212165 475 6836383 SGTC_807 1315-0151 48 µM 0.16568688443312 0.424838200043389 no 1397 0.434201684047234 475 4011080 SGTC_124 0136-0217 7.121 µM 0.165148366559865 0.425072417476983 no 1398 0.434413602309821 453 3976905 SGTC_2902 5787006 60.46 µM 0.165117793951895 0.425085715207349 no 1399 0.434425633848717 451 591003 SGTC_1431 4049-0260 9.09 µM 0.163881141338767 0.425623675613529 no 1400 0.434912356701451 476 3854841 SGTC_2667 digitoxin 100 µM 0.162951280212661 0.426028268890981 no 1401 0.435278397299538 470 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1476 4112-3294 3.34 µM 0.162583243721174 0.426188427339936 no 1402 0.435423290506219 484 704369 SGTC_3262 9137218 49.47 µM 0.162176644000812 0.426365381504105 no 1403 0.435583375846606 478 17650664 SGTC_1449 4112-4002 201 µM 0.161684309365586 0.42657966775785 no 1404 0.435777230633092 439 2059539 SGTC_2339 9000433 200 µM 0.161029593030124 0.426864663421613 no 1405 0.436035046460498 449 2988954 SGTC_1236 0330-0013 258 µM 0.160018514102193 0.427304857401999 no 1406 0.436433245000272 470 4617066 SGTC_334 1502-1024 68.5 µM 0.159974869563292 0.427323860990584 no 1407 0.436450435212397 483 3296216 SGTC_1911 st060208 74.3 µM 0.159713106455642 0.427437840721238 no 1408 0.436553537990796 458 688783 SGTC_696 1560-0013 611 µM 0.159428816562197 0.427561636170086 no 1409 0.43666551846143 447 1650269 SGTC_2075 5212009 200 µM 0.159382713234994 0.42758171276577 no 1410 0.436683678826733 497 780898 SGTC_2774 tamoxifen 10.92 µM 0.158219581873457 0.428088282977832 no 1411 0.43714188699941 464 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_21 0849-0113 22.993 µM 0.158118672356575 0.428132236971762 no 1412 0.437181643643452 457 1560156 SGTC_3196 9111891 49.47 µM 0.157991846422543 0.428187480858681 no 1413 0.437231611817404 491 18891510 SGTC_57 miconazole 162.5 nM 0.157846745066733 0.428250687030868 no 1414 0.43728878155628 478 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1698 5-fluorocytosine 1.055 µM 0.157542989720102 0.428383008863252 no 1415 0.437408464992318 482 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_734 2023-0417 80 µM 0.157132946537072 0.42856164454658 no 1416 0.437570036258253 493 3935732 SGTC_1217 1183-1422 255 µM 0.156950906050272 0.428640955342971 no 1417 0.437641769875637 463 2849664 SGTC_2753 fluvastatin 17.09 µM 0.156617437412506 0.428786247327098 no 1418 0.437773179539046 455 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_611 3453-1652 23.7 µM 0.156466188409922 0.428852149563394 no 1419 0.437832784350427 472 1560575 SGTC_1079 idarubicin 2.36 µM 0.155069183968876 0.42946094607206 no 1420 0.43838338795519 489 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_130 0136-0219 337.655 µM 0.155001340928302 0.429490515477714 no 1421 0.438410130087493 491 234244 SGTC_2879 9041815 71.43 µM 0.154967329473254 0.429505339527512 no 1422 0.438423536709651 489 4942971 SGTC_2520 obtusaquinone 4.71 µM 0.154570508548696 0.429678303100793 no 1423 0.438579960645439 498 5967872 SGTC_3002 9075603 71.4286 µM 0.154339904709763 0.429778823318597 no 1424 0.438670867418951 493 20105405 SGTC_1107 amlodipine 47 µM 0.15372705484007 0.430045986696546 no 1425 0.438912475832617 478 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_491 tetrandrine 80.3 µM 0.153547147698982 0.43012442080003 no 1426 0.438983406304002 474 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.152539490987888 0.43056377971197 no 1427 0.43938072277644 504 6708630 An antioxidant. SGTC_3149 9097855 49.47 µM 0.152095350676774 0.430757461289833 no 1428 0.439555865584808 517 25236625 YMR079W SEC14 SGTC_612 0302-0167 22.4 µM 0.151578813869964 0.430982734620273 no 1429 0.439759572191094 466 235821 SGTC_1372 2752-0194 270 µM 0.151140341854346 0.431173979763041 no 1430 0.439932504906301 480 823334 SGTC_3069 9117009 49.47 µM 0.150241041228311 0.431566271605463 no 1431 0.440287223567162 490 41904981 SGTC_699 0375-0592 111 µM 0.149439676039672 0.431915899059363 no 1432 0.440603353128305 488 762578 SGTC_3122 9126309 49.47 µM 0.147994840372827 0.432546400703823 no 1433 0.441173420094799 506 17591206 SGTC_153 4077-0274 519.67 µM 0.147340720557341 0.432831904026905 no 1434 0.441431546420979 492 3121976 SGTC_2191 5911152 200 µM 0.147249198267996 0.432871853511007 no 1435 0.441467664592537 464 2875902 SGTC_2821 7996764 71.43 µM 0.146496711734019 0.433200339896496 no 1436 0.441764642785777 454 2987135 SGTC_1832 st054113 55 µM 0.145624145274574 0.433581303099264 no 1437 0.442109053001268 488 1251267 SGTC_2167 5876490 200 µM 0.144756466467918 0.433960193548791 no 1438 0.442451577413377 489 686534 SGTC_123 0083-0120 66.675 µM 0.141107577295108 0.435554219013936 no 1439 0.443892478866705 488 16001701 SGTC_2026 5148700 152 µM 0.140807269206738 0.435685456291918 no 1440 0.444011100144017 465 79838 SGTC_2477 5967686 25.23 µM 0.140674197083715 0.435743612246523 no 1441 0.444063665052011 465 776118 SGTC_1860 st056228 74.6 µM 0.138849090431497 0.436541370680265 no 1442 0.444784700554043 503 688679 SGTC_212 3807-4682 38.772 µM 0.138208620158489 0.436821383114664 no 1443 0.445037771289453 462 3125501 YBL034C STU1 SGTC_3068 9116768 49.47 µM 0.137919539344986 0.436947779095996 no 1444 0.445152003909816 489 41904888 SGTC_2653 dihydrofissinolide 100 µM 0.137018187611048 0.437341922050543 no 1445 0.445508209531293 470 6857746 SGTC_1514 1189-1591 158 µM 0.135588414223486 0.437967260563537 no 1446 0.44607333248731 502 767698 YMR146C TIF34 SGTC_2937 9044753 11.33 µM 0.134769521947177 0.438325488521015 no 1447 0.446397051957211 484 6465530 YGL099W LSG1 SGTC_620 0109-0052 432 µM 0.134063216070752 0.438634505678135 no 1448 0.446676293167872 492 493037 SGTC_2557 derrustone 83.84 µM 0.133859303898363 0.438723726628215 no 1449 0.446756915689016 490 629853 An antioxidant. SGTC_2572 astragaloside iv 100 µM 0.132874214441044 0.439154792331663 no 1450 0.447146429973102 460 45006101 An anti-inflammatory agent. SGTC_2029 5175081 200 µM 0.132822583445911 0.439177387554988 no 1451 0.447166846797598 471 1380876 SGTC_1336 1486-0901 104 µM 0.132099398123168 0.439493895255938 no 1452 0.447452835984577 449 5006114 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.130464439744143 0.440209589822322 no 1453 0.448099493306707 501 368090 SGTC_2419 paclitaxel 166.5 µM 0.13004316798356 0.440394031108115 no 1454 0.448266136768416 498 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1305 1181-0477 144 µM 0.128507562271111 0.441066459511557 no 1455 0.44887365700949 478 6252086 SGTC_2357 9067248 200 µM 0.128262824981777 0.441173643595043 no 1456 0.448970491712497 486 9150235 SGTC_2412 st077135 33.4 µM 0.128064226837285 0.441260623945789 no 1457 0.449049072868809 489 13258915 SGTC_3019 9081971 49.47 µM 0.12781917527791 0.441367953478223 no 1458 0.449146037429664 478 16451803 SGTC_1017 4239-0030 168 µM 0.127560918161357 0.441481071540412 no 1459 0.449248230590335 478 1149593 SGTC_7 0192-1582 4.227 µM 0.126706365347767 0.44185540443428 no 1460 0.449586403814759 500 252616 SGTC_2778 tioconazole 65.09 nM 0.126693937672614 0.441860848703633 no 1461 0.449591322104495 489 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1155 4088-0394 48.2 µM 0.125235232077216 0.442499949011338 no 1462 0.45016866281835 487 2326248 SGTC_2089 5281248 129.67 µM 0.124618038913478 0.442770404003716 no 1463 0.450412973368663 461 2737878 SGTC_650 1328-0195 38 µM 0.124007263625577 0.443038072929386 no 1464 0.4506547619583 501 2780821 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.122680263170691 0.443619713054084 no 1465 0.451180146749466 492 23665772 A membrane-active detergent. SGTC_231 b-estradiol 524 µM 0.12259990413251 0.443654939292446 no 1466 0.451211965181401 496 450 A steroid. SGTC_2663 amphotericin b 100 µM 0.122102696596086 0.443872905389098 no 1467 0.451408843143205 487 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2840 9008771 71.43 µM 0.121107206129332 0.444309359979908 no 1468 0.451803060762926 499 2992978 SGTC_3286 9117135 37.221 µM 0.121044045297371 0.444337053975842 no 1469 0.451828074275321 501 3438150 SGTC_332 4112-0506 40.9 µM 0.121006511125064 0.444353511633454 no 1470 0.451842938981456 510 2790355 SGTC_820 1582-0060 59.9 µM 0.12061251395425 0.444526273872361 no 1471 0.451998978253565 474 3848840 SGTC_961 1252-1571 372 µM 0.120099813587681 0.444751101575504 no 1472 0.452202040029295 499 6813498 SGTC_1596 piperlongumine 63 µM 0.119769019939419 0.444896169572784 no 1473 0.452333061877825 455 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2251 lansoprazole 556 µM 0.118847865300812 0.44530017643509 no 1474 0.452697943181324 490 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2328 6201408 200 µM 0.118621422548629 0.44539950010015 no 1475 0.452787646222298 484 2890418 SGTC_3261 9137475 49.47 µM 0.118345439810606 0.445520557921503 no 1476 0.452896977292737 508 17027690 SGTC_1333 1482-0047 286 µM 0.117318025907988 0.445971270126203 no 1477 0.453304020530291 512 3811116 SGTC_2150 5556613 200 µM 0.116444704319855 0.446354439097893 no 1478 0.453650053710836 473 743190 SGTC_3182 9108849 49.47 µM 0.116257942610957 0.446436387124838 no 1479 0.453724058230688 475 17133045 SGTC_2529 gangaleoidin 93.61 µM 0.115994577390183 0.446551951424561 no 1480 0.453828419701189 503 4565183 SGTC_2842 9000675 19.48 µM 0.115416935219976 0.446805435904584 no 1481 0.4540573281499 511 2989072 SGTC_875 0709-0210 25.7 µM 0.115366705644536 0.446827478983607 no 1482 0.454077233884001 502 6251364 SGTC_274 sirtinol 40.1 µM 0.11492298598147 0.44702221098254 no 1483 0.454253082812296 471 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3270 9137563 49.47 µM 0.11446729973136 0.447222207964374 no 1484 0.454433683508343 507 17015724 SGTC_1127 asiatic acid 681.4 nM 0.113890690134772 0.447475296447752 no 1485 0.454662222870816 461 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2085 5307070 144.047 µM 0.113618812239046 0.44759463793403 no 1486 0.454769986956364 490 2840351 SGTC_1613 st002381 52.1 µM 0.112453418677937 0.448106243991099 no 1487 0.455231950953087 487 551167 SGTC_326 k292-0812 17.5 µM 0.111465644726619 0.448539942931182 no 1488 0.45562355366492 504 3579357 SGTC_79 0052-0007 94.094 µM 0.11119878869934 0.448657121179523 no 1489 0.455729356077452 503 2801472 SGTC_200 k038-0079 37.545 µM 0.110936147630723 0.448772452985208 no 1490 0.455833490419358 499 3436683 SGTC_3258 9138477 49.47 µM 0.110590257032025 0.448924348200328 no 1491 0.455970636927195 481 4970355 SGTC_1060 3448-7350 82 µM 0.109907062707325 0.449224389746882 no 1492 0.456241540625139 472 570178 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.109723862816516 0.449304851417044 no 1493 0.456314187444133 486 115019 SGTC_2849 9019321 12.99 µM 0.1087773638023 0.449720588356163 no 1494 0.456689539165787 506 16489627 SGTC_366 0181-0206 4.31 µM 0.107384592665064 0.450332444547081 no 1495 0.457241938548124 474 274874 SGTC_221 trifluoperazine 10.304 µM 0.106362587108286 0.450781495458378 no 1496 0.457647337905791 514 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2956 9076196 2.52 µM 0.105985400424821 0.450947240470136 no 1497 0.457796967856226 518 16423868 SGTC_772 k072-0172 35.3 µM 0.105722471790129 0.451062782774621 no 1498 0.457901275180265 470 5861980 SGTC_2950 9072895 21.46 µM 0.105586572125557 0.451122504637928 no 1499 0.457955189541249 480 17332245 SGTC_2434 5670830 169.91 µM 0.104839350866523 0.451450894906152 no 1500 0.45825164230658 493 1549830 SGTC_1768 st044301 37.178 µM 0.104680199478112 0.451520843371045 no 1501 0.458314787077302 512 3931349 SGTC_2702 st077768 96.8 µM 0.104209067681015 0.451727918843044 no 1502 0.458501719092519 480 6484119 SGTC_2655 perillic acid 100 µM 0.104039398030315 0.451802496573008 no 1503 0.458569041548647 507 5702197 An apoptosis inducer. SGTC_2764 methyldopa 94.69 µM 0.103577879386323 0.452005364154292 no 1504 0.458752171458901 496 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_157 1348-1695 65.819 µM 0.103395808486098 0.452085399654386 no 1505 0.458824419331018 479 5380510 SGTC_1758 st042942 75.2445 µM 0.102901502386509 0.452302698640667 no 1506 0.459020572650218 507 669317 SGTC_445 e6 berbamine 66 µM 0.102492710441602 0.452482416051253 no 1507 0.459182799302653 502 6610268 A calcium/calmodulin antagonist. SGTC_3244 9134489 49.47 µM 0.101595162223173 0.452877039734034 no 1508 0.459539009783793 505 16584271 SGTC_13 0199-0087 65 µM 0.101323979606844 0.452996279363296 no 1509 0.459646640588562 507 4589825 SGTC_1339 1486-1321 22.7 µM 0.101086984117235 0.453100490304151 no 1510 0.459740705143335 483 3469382 SGTC_1006 4099-6547 255 µM 0.100917108558012 0.453175189459761 no 1511 0.459808130888678 485 3146833 SGTC_2912 7964298 10.93 µM 0.10004416336882 0.453559074573618 no 1512 0.460154631999929 505 2975850 SGTC_2035 5154463 94.595 µM 0.0991203674364507 0.453965368993229 no 1513 0.460521350422504 514 2769623 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0986668211732705 0.454164860703139 no 1514 0.460701406575763 492 88881 An O-methylated flavonoid and antioxidant. SGTC_2843 9000894 45.46 µM 0.0984750905768876 0.454249196626712 no 1515 0.460777525323527 496 2242070 SGTC_80 0159-0065 512.242 µM 0.0975639732281224 0.454649995024702 no 1516 0.461139266589109 496 1548079 SGTC_1173 0443-0020 122 µM 0.0960423648140238 0.455319449769509 no 1517 0.461743462901722 496 5331295 SGTC_2201 6605497 169.863 µM 0.0942469101507579 0.45610955040328 no 1518 0.462456510835046 500 670741 SGTC_1611 st001856 99.4 µM 0.093645461452727 0.456374260492305 no 1519 0.462695397623365 521 647478 SGTC_522 1273-0010 11.6 µM 0.0936441837956082 0.456374822836444 no 1520 0.462695905104782 509 5705015 SGTC_389 tpck 16.7 µM 0.0935122849893158 0.456432876847945 no 1521 0.462748295225241 464 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_182 3448-4371 550.524 µM 0.0927368596230038 0.45677419174978 no 1522 0.463056306715255 510 3491403 SGTC_1359 1582-0056 520 nM 0.092641490980535 0.456816171870585 no 1523 0.463094190214984 497 3661189 SGTC_2872 9044037 25.97 µM 0.0925762592022851 0.456844886386531 no 1524 0.463120102573337 501 6465195 SGTC_2288 7946289 167.31 µM 0.0905296502122243 0.45774590124594 no 1525 0.463933166610789 507 1246052 SGTC_2257 7960413 200 µM 0.0886163159345149 0.458588438765022 no 1526 0.464693420429914 502 2974689 YIL048W NEO1 SGTC_2102 5377816 72.7585 µM 0.0883371539049512 0.458711383522248 no 1527 0.464804354910455 519 1379702 SGTC_185 k048-0037 25.491 µM 0.0878197334955605 0.458939269241417 no 1528 0.465009976649909 512 6827589 SGTC_3308 9128332 17.569 µM 0.0877125417991951 0.458986481007128 no 1529 0.465052575565836 507 17332805 YDL196W YDL196W SGTC_2614 arthonioic acid 13.39 µM 0.0865698151652175 0.459489822066138 no 1530 0.465506729903068 498 6710684 SGTC_543 3844-1095 191 µM 0.0865420796561405 0.459502039639654 no 1531 0.465517753399226 511 4230703 SGTC_740 k014-0057 261 µM 0.0865034179006824 0.459519070320724 no 1532 0.465533119583275 520 4012779 SGTC_459 nigericin 15.3 µM 0.0855182595996448 0.459953062059683 no 1533 0.465924689792961 499 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_550 4123-0385 25.7 µM 0.0837893680433929 0.460714805614636 no 1534 0.466611950682671 503 5731123 SGTC_1899 st063254 59.6 µM 0.0836291106516264 0.460785421803864 no 1535 0.466675660525463 513 3093813 SGTC_3109 9122853 49.47 µM 0.0834340241748478 0.460871386830781 no 1536 0.466753217718182 517 1234709 SGTC_3056 9094900 49.47 µM 0.0830681629632483 0.461032608821403 no 1537 0.466898670301721 488 25236784 SGTC_1657 st012939 43.4 µM 0.0821776326061814 0.461425060512749 no 1538 0.467252729934958 520 24207257 SGTC_1087 pterostilbene 9.05 µM 0.0821189104180925 0.461450940373346 no 1539 0.467276077785923 511 5281727 Similar to reservatol, lowers cholesterol. SGTC_219 mitoxanthrone 164.414 µM 0.0815506429020671 0.461701393887698 no 1540 0.467502025874168 488 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_554 4483-2211 187 µM 0.0814744190950774 0.461734989293991 no 1541 0.467532333918349 498 747107 SGTC_1670 st016595 4.04 µM 0.0803948085097072 0.462210853515835 no 1542 0.467961627875332 517 597879 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0803417972045063 0.462234220917075 no 1543 0.467982708136882 499 23847180 SGTC_2894 9048625 32.47 µM 0.0795883592486194 0.462566350675988 no 1544 0.468282326909877 521 4092861 SGTC_142 0335-0849 62.6745 µM 0.0791505596166785 0.462759353071814 no 1545 0.468456434431321 508 3889043 YPR107C YTH1 SGTC_2514 salinomycin 42.74 µM 0.079107951636578 0.462778137115741 no 1546 0.468473379422919 507 23682228 A polyether potassium ionophore. SGTC_2642 cholecalciferol 100 µM 0.0788536908154268 0.462890231607938 no 1547 0.468574498931856 501 9821465 A vitamin D precursor, similar to steriods. SGTC_1828 st055811 49 µM 0.0781978807185758 0.463179368379438 no 1548 0.468835323899421 521 5877589 SGTC_1419 3993-2473 62.6 µM 0.0781448543865251 0.463202747740804 no 1549 0.46885641380899 523 704026 SGTC_1488 4013-0813 75.9 µM 0.0778907541858619 0.463314782528735 no 1550 0.468957477078879 518 2910057 SGTC_321 4534-3890 65.3 µM 0.0777909910765884 0.463358769668485 no 1551 0.468997156406375 519 699746 SGTC_3251 9135047 49.47 µM 0.0776803717370234 0.463407544016365 no 1552 0.469041154001776 512 17682963 SGTC_177 1327-0068 8.361 µM 0.0776469349360579 0.463422287099699 no 1553 0.469054453186893 503 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2064 5220758 200 µM 0.0750021019735419 0.464588614539898 no 1554 0.470106519736207 507 788518 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0739412112262438 0.46505653583404 no 1555 0.470528581882044 515 2374 Ca(2+)-ATPase inhibitor. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0732897869711375 0.465343879963742 no 1556 0.470787759330389 486 16623 A steroid. SGTC_3123 9126162 49.47 µM 0.0732464784828186 0.465362984039446 no 1557 0.470804990604723 520 25239884 SGTC_1321 1326-2144 215 µM 0.0731090031685875 0.465423627156051 no 1558 0.470859688670227 526 3513030 SGTC_1644 st010134 20.9 µM 0.0729406097680248 0.465497909954284 no 1559 0.47092668903518 524 3818134 SGTC_377 3970-0964 33.1 µM 0.0728788066356477 0.465525173257982 no 1560 0.470951279471571 514 16481235 SGTC_2671 danthron 100 µM 0.0721862640962829 0.465830686569453 no 1561 0.471226838159001 509 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0721777987225429 0.465834421171667 no 1562 0.471230206567946 510 688803 SGTC_428 3448-4153 16.5 µM 0.0702430755492518 0.466688026016238 no 1563 0.472000094822819 499 3834874 SGTC_1469 k284-2957 126 µM 0.0701998965520992 0.466707078463725 no 1564 0.472017278331704 508 23884841 SGTC_953 1188-0045 9.7 µM 0.068093546119197 0.467636583479295 no 1565 0.472855583942362 513 6144426 SGTC_937 3122-0005 46.7 µM 0.0680198668802464 0.467669100392143 no 1566 0.47288490971295 524 759535 SGTC_697 0508-1955 564 µM 0.0677392377859207 0.467792952611083 no 1567 0.472996606896923 523 6243113 SGTC_2395 5646831 180.19 µM 0.0677121738658167 0.46780489710628 no 1568 0.473007379105746 515 6808628 SGTC_851 0394-0702 453 µM 0.0664415440523675 0.468365714225936 no 1569 0.473513147942202 502 762646 SGTC_675 1309-0189 238 µM 0.065445901548335 0.468805204290771 no 1570 0.47390948911977 509 4246530 SGTC_1255 0566-0045 221 µM 0.0651111584345234 0.468952972993606 no 1571 0.474042748070351 521 2788469 SGTC_74 000s-0487 160.283 µM 0.0623830450886402 0.470157426590672 no 1572 0.475128898359408 512 677548 SGTC_2682 pyrogallin 40.03 µM 0.062281409801088 0.470202303600219 no 1573 0.475169366281224 511 822798 An ATP competetive kinase inhibitor. SGTC_2194 5927483 104.545 µM 0.0606139249003365 0.470938634336031 no 1574 0.475833341724779 495 760979 SGTC_782 0083-0095 30.5 µM 0.0601235267817605 0.471155204168044 no 1575 0.47602862609662 494 3591729 An indicator and reagent. SGTC_1292 0kpi-0043 232 µM 0.0594826568858052 0.4714382382608 no 1576 0.476283839408013 525 3333905 SGTC_2044 5102272 200 µM 0.0594137917454112 0.471468652755816 no 1577 0.476311264120595 515 592666 SGTC_3344 9148862 3.898 µM 0.0593714833331565 0.471487338475031 no 1578 0.476328112991763 509 4905352 SGTC_1765 st044815 90.4 µM 0.0589327684217082 0.471681102774598 no 1579 0.476502828986689 530 645695 SGTC_899 1083-0020 478 µM 0.0588220909550888 0.471729986016431 no 1580 0.47654690644295 526 767123 SGTC_761 k216-0224 480 µM 0.0584151504872865 0.471909724264394 no 1581 0.476708973517919 523 1340404 SGTC_2309 7664088 163.95 µM 0.0582783205886643 0.471970160844027 no 1582 0.476763467911905 517 704922 SGTC_922 1866-0035 480 µM 0.0576458116800677 0.472249542909497 no 1583 0.477015378938189 514 3156169 SGTC_2115 tiliquinol 12.7705 µM 0.0572764773603616 0.472412685883638 no 1584 0.477162478966326 519 71208 A bioactive hydroxyquinoline. SGTC_2717 st081029 62.2815 µM 0.0562453535860257 0.472868180015901 no 1585 0.477573175693235 533 5292846 SGTC_1711 st032263 62.8 µM 0.055503788218371 0.47319578503752 no 1586 0.477868556021338 504 3958979 SGTC_230 MPP+ 141.667 µM 0.0548785817659232 0.473471999697928 no 1587 0.478117597717327 512 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_880 0833-0487 87.2 µM 0.0542543354596779 0.473747802893809 no 1588 0.478366265478603 519 76075 SGTC_1042 0350-0096 82 µM 0.0538219310325491 0.473938854297611 no 1589 0.478538518202487 505 3122515 SGTC_2346 9031566 143.75 µM 0.0533343454919411 0.474154293835974 no 1590 0.47873275769427 523 4771086 SGTC_3021 9087658 49.47 µM 0.0531632238835072 0.474229905667205 no 1591 0.478800928623286 531 25237042 SGTC_1166 k206-0078 225 µM 0.0520787286634593 0.474709122433511 no 1592 0.479232981014606 519 5404595 SGTC_3118 9124250 49.47 µM 0.0520379730851439 0.474727132226916 no 1593 0.479249218121181 524 1504786 SGTC_848 0368-0089 85.6 µM 0.047848432968255 0.476578748940924 no 1594 0.480918518403688 531 762535 SGTC_2985 9022375 71.43 µM 0.046781737461211 0.477050269987714 no 1595 0.481343592245153 505 4939335 SGTC_2113 5491891 107.031 µM 0.0451890191381191 0.477754373256507 no 1596 0.48197832338437 522 789979 SGTC_12 0849-0099 9.267 µM 0.0445179336654223 0.478051065264005 no 1597 0.482245778575049 536 6071388 SGTC_3315 9136395 68.55 µM 0.0444384621346721 0.47808620104285 no 1598 0.482277451783531 534 16876844 SGTC_2183 6420625 130.508 µM 0.0421222409059468 0.479110317390555 no 1599 0.483200625112246 509 2897619 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.039804085144583 0.480135427193645 no 1600 0.484124659669888 532 6728940 SGTC_2429 5902844 64.44 µM 0.0370422557653829 0.48135690450955 no 1601 0.485225656807734 532 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_477 mead ethanolamide 10 µM 0.0368055193999331 0.481461614470111 no 1602 0.485320036593618 530 16061185 SGTC_1879 gemcitabine 100 µM 0.036255722189827 0.48170479810302 no 1603 0.485539227641093 531 60750 A nucleoside analog which inhibits DNA replication. SGTC_2525 harmine 47.85 µM 0.0360739998725887 0.481785178137566 no 1604 0.485611676963006 530 5280953 A monoamine oxidase inhibitor SGTC_2448 5185112 27.17 µM 0.0354981488457002 0.4820398954013 no 1605 0.485841261226844 526 5718189 SGTC_2983 9022671 12.99 µM 0.0349592837455301 0.482278259253256 no 1606 0.486056103938154 531 6405161 SGTC_1465 k213-0056 144 µM 0.033786529267947 0.482797042176274 no 1607 0.486523688950331 529 24048857 YMR208W ERG12 SGTC_1318 1280-3875 124 µM 0.0330198279808241 0.483136218084951 no 1608 0.486829387909916 524 373245 SGTC_1731 st035964 63 µM 0.0327291032712342 0.48326483306989 no 1609 0.486945307632205 513 6739575 SGTC_1256 0570-0116 285 µM 0.0326807383542372 0.483286229607882 no 1610 0.486964592126261 518 410638 SGTC_717 1532-0246 73.2 µM 0.0319912873979473 0.483591246471237 no 1611 0.48723949949596 524 9561992 SGTC_2834 9001755 58.44 µM 0.0313663170726698 0.483867745054377 no 1612 0.487488701504376 528 2989575 SGTC_1728 st035614 33.7865 µM 0.031192003748519 0.48394486592477 no 1613 0.487558208448705 514 15945546 SGTC_1995 st072814 61.1 µM 0.0310282455748785 0.48401731746189 no 1614 0.487623506900989 527 5769371 SGTC_1818 st052136 56.3 µM 0.0299309278489114 0.484502817297622 no 1615 0.488061070018549 532 674169 SGTC_128 0906-2981 13.371 µM 0.0295105401609532 0.484688820741383 no 1616 0.488228706385402 527 6740226 SGTC_262 fenpropimorph 62.5 µM 0.0268014805345135 0.48588754108709 no 1617 0.489309036173794 541 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2978 9011784 42.97 µM 0.0261861031066356 0.48615985500867 no 1618 0.489554450098598 530 2994934 SGTC_416 estradiol valerate 100 µM 0.0231305075699928 0.487512095856195 no 1619 0.490773085335086 530 13791 A steroid. SGTC_616 4092-0450 108 µM 0.0231030476790872 0.487524248788721 no 1620 0.490784037319901 536 787165 SGTC_1289 0976-0073 69.1 µM 0.0225480608362171 0.48776987195743 no 1621 0.491005387363895 536 3391136 SGTC_313 3474-0040 5.03 µM 0.0223911886980287 0.487839300451311 no 1622 0.491067954495804 535 1043375 YIL048W NEO1 SGTC_2408 sulbentine 18.36 µM 0.0210566822915593 0.48842994118219 no 1623 0.491600219874672 511 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1799 st045822 46.1415 µM 0.019942351238128 0.488923153745363 no 1624 0.492044680225619 538 3674992 SGTC_2068 5226020 147 µM 0.01874694617417 0.489452269179642 no 1625 0.492521488596581 531 1810509 SGTC_1456 k015-0012 13 µM 0.018235583417688 0.489678616529678 no 1626 0.49272545794426 532 2989616 SGTC_2921 7974240 10.71 µM 0.0181796756615517 0.489703363494603 no 1627 0.492747758215208 539 2979074 YDR527W RBA50 SGTC_1708 st033234 31.827 µM 0.0176584658022837 0.489934073308736 no 1628 0.49295565748249 537 674664 SGTC_2744 captopril 92.04 µM 0.0174307277697511 0.490034880980837 no 1629 0.493046497830336 539 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1694 st024011 44.9 µM 0.016901220175164 0.490269268646549 no 1630 0.493257709673884 534 2787533 SGTC_2033 5192550 145 µM 0.0162201680257022 0.490570742761677 no 1631 0.493529372910942 542 182073 SGTC_959 1222-0044 107 µM 0.0150299271407568 0.491097626871837 no 1632 0.494004152335424 537 6083612 SGTC_2218 6965428 192.983 µM 0.0149570549760926 0.491129885717821 no 1633 0.494033220855412 538 675684 SGTC_3027 9089541 49.47 µM 0.0142751076850095 0.491431771020166 no 1634 0.494305249399302 538 9943819 SGTC_2597 laccaic acid a 100 µM 0.0135881074379304 0.491735898133709 no 1635 0.494579296242995 539 5491415 A textile dye. SGTC_2005 4024620 188 µM 0.0131583357355066 0.491926155580861 no 1636 0.494750735013691 547 236743 SGTC_2285 7945142 200 µM 0.0130725091877792 0.491964150718596 no 1637 0.494784971907605 544 2970608 SGTC_628 1636-0253 16 µM 0.0128563437717333 0.492059846778091 no 1638 0.494871202184519 537 4456143 SGTC_405 ebelactone b 50 µM 0.0122895150928441 0.492310783019698 no 1639 0.495097316234647 537 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.011987566136383 0.492444457702784 no 1640 0.495217767565218 536 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_712 r015-0009 80.6 µM 0.0108567951354171 0.492945064482137 no 1641 0.495668850476426 538 6813872 YLR060W FRS1 SGTC_133 0724-0033 378.92 µM 0.010656916158619 0.493033554638801 no 1642 0.495748586037869 545 280309 SGTC_3264 9137442 49.47 µM 0.00954294734766217 0.493526735597696 no 1643 0.496192972606423 538 17015726 SGTC_2817 7995342 71.43 µM 0.00952194913812865 0.49353603211075 no 1644 0.496201349299425 544 18879975 SGTC_825 1988-2224 89.6 µM 0.00872681073875714 0.493888065353765 no 1645 0.496518550412895 541 1180859 SGTC_2762 leflunomide 42.06 µM 0.0078502182217338 0.494276166449646 no 1646 0.49686824820719 545 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_253 dyclonine 31.25 µM 0.00771693959619854 0.494335174487616 no 1647 0.496921417075332 543 3180 An oral anasthetic. SGTC_1888 azatryptophan 97.5 µM 0.00733415677983953 0.494504649181185 no 1648 0.497074120999888 540 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_340 k038-0059 454 µM 0.0071869749585204 0.49456981327606 no 1649 0.497132836503627 542 23733424 SGTC_3106 9121286 49.47 µM 0.00681701031480743 0.494733614107825 no 1650 0.497280427423335 544 15943471 SGTC_2895 9054447 58.44 µM 0.00648861792204957 0.494879009684185 no 1651 0.497411434133573 544 2697450 SGTC_1441 4106-0040 13 µM 0.00622957937638632 0.494993699358496 no 1652 0.497514773471957 542 2904180 SGTC_3205 9113483 49.47 µM 0.00611132309180779 0.495046057630172 no 1653 0.497561950005652 547 17018033 SGTC_1910 st062352 60.4 µM 0.00588863962307714 0.495144651534963 no 1654 0.497650786257235 547 2245730 SGTC_1620 st003704 16.5 µM 0.00573943227592833 0.495210713789591 no 1655 0.497710310370448 544 2834414 SGTC_211 3455-0679 143.504 µM 0.00410112839298443 0.495936088780257 no 1656 0.49836389107304 536 748649 SGTC_404 fumagillin 50 µM 0.00407579378486578 0.495947306036273 no 1657 0.498373998034904 544 12015870 A methionine aminopeptidase binder. SGTC_2294 7971431 200 µM 0.003848008649011 0.49604816126928 no 1658 0.498464870443048 544 5741572 SGTC_155 k072-0202 43.6 µM 0.00378384108022901 0.496076572453912 no 1659 0.498490469412883 546 5857737 SGTC_2037 5169046 200 µM 0.00349320095272698 0.49620525811763 no 1660 0.498606417280207 546 5718022 SGTC_729 4092-0585 94.1 µM 0.0027710252316364 0.4965250148949 no 1661 0.498894522289791 547 2169061 SGTC_2466 5983409 37.09 µM 0.00270991215990572 0.496552073953193 no 1662 0.498918902786435 544 2879657 SGTC_996 3970-0799 1.8 µM 0.00231644410192226 0.496726290331113 no 1663 0.499075873334021 536 6615648 YGL040C HEM2 SGTC_3158 9100007 49.47 µM 0.00214591132644743 0.496801797551919 no 1664 0.499143905898931 545 19297233 SGTC_1287 0971-0001 34.6 µM 0.000738723973107909 0.497424865517319 no 1665 0.499705291800385 546 4665869 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.000734569345196749 0.497426705094467 no 1666 0.499706949256669 547 6857784 SGTC_3221 9128209 49.47 µM 0.000641229609860264 0.497468033874683 no 1667 0.499744186414712 547 16460723 SGTC_1106 tegaserod maleate 11.7 µM 0.000332800799114665 0.497604599553782 no 1668 0.499867231692733 547 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3299 9121982 43.1275 µM 0.000325499078886121 0.497607832602756 no 1669 0.499870144657494 547 17594604 YPL160W CDC60 SGTC_2461 5755302 26.15 µM 4.70181595517911e-05 0.497731138243655 no 1670 0.499981242468215 547 2788904 SGTC_2161 5662504 8.5105 µM -0.000963692408488198 0.498178661892982 no 1671 0.49961554241246 548 2859334 SGTC_2581 avocatin a 64 µM -0.000989704720026392 0.498190179688453 no 1672 0.499605165006526 550 6710728 A skin care supplement. SGTC_2377 9073351 62.6 µM -0.00143669009414916 0.498388097202652 no 1673 0.499426843774783 550 7337946 YHR072W ERG7 SGTC_1882 5615643 20 µM -0.00156701227777982 0.498445801723826 no 1674 0.49937485280433 548 2253075 SGTC_845 0330-0138 4.51 µM -0.00207580451998298 0.498671086867194 no 1675 0.499171874405858 549 9039800 SGTC_3029 9088683 49.47 µM -0.00427583136567572 0.499645227858227 no 1676 0.498294195282163 550 25236615 SGTC_34 0469-0683 81.75 µM -0.00475998737567493 0.499859605826872 no 1677 0.498101046952584 549 3690923 SGTC_1734 st037168 69.4 µM -0.00503313644302168 0.499980552694343 no 1678 0.497992077547456 558 708907 SGTC_1459 k035-0031 35.7 µM -0.00512097688715881 0.499980552694343 no 1679 0.497957034732016 550 3877128 YMR208W ERG12 SGTC_538 2922-0838 53.3 µM -0.00541407721284554 0.499850771668584 no 1680 0.497840106242328 558 777039 SGTC_2406 ethylparaben 405.7 µM -0.0060390591736188 0.499574037825907 no 1681 0.497590778605952 565 8434 A possible steroid mimic. SGTC_2723 salbutamol 83.58 µM -0.00669298537862626 0.499284488071853 no 1682 0.497329905085325 549 9884233 β2-adrenoceptor agonist SGTC_1096 rimcazole 32.2 µM -0.00720061587487725 0.499059716347749 no 1683 0.497127394706159 561 18528119 A dopamine reuptake inhibitor. SGTC_3165 9101544 49.47 µM -0.00796577163481616 0.498720916605127 no 1684 0.496822150506506 551 5002184 SGTC_281 1672-3440 14.9 µM -0.00811763680486248 0.49865367303825 no 1685 0.496761567028281 551 6833000 SGTC_35 0133-0054 64.071 µM -0.00820999544239454 0.498612778069406 no 1686 0.496724722490648 559 99677 SGTC_752 1896-0090 130 µM -0.00879415929877947 0.498354119750859 no 1687 0.496491683255777 554 772567 SGTC_66 0109-0187 42.4 µM -0.00937506111665422 0.498096906496167 no 1688 0.496259946525953 553 759417 SGTC_1018 4259-0013 28.1 µM -0.0101180157722948 0.497767940221602 no 1689 0.495963564585951 563 6801262 SGTC_426 0988-0037 14.6 µM -0.01037779979679 0.497652913113949 no 1690 0.49585993119701 555 5383008 SGTC_1622 st003707 19.4 µM -0.0116493541308951 0.497089897586889 no 1691 0.495352685210596 550 10140899 SGTC_3130 9127414 49.47 µM -0.0127709975386052 0.496593264005487 no 1692 0.494905247610299 558 1494646 SGTC_1338 1486-1223 76 µM -0.0132256676120415 0.496391949766646 no 1693 0.494723875818567 554 3444526 SGTC_3174 9107204 49.47 µM -0.0133230895782717 0.496348814366776 no 1694 0.494685013501312 552 3938802 SGTC_2276 7947513 42.08 µM -0.0134089791264717 0.496310785196336 no 1695 0.494650751589698 575 2105100 SGTC_1257 0669-0121 16 µM -0.014125204879559 0.49599366446558 no 1696 0.494365045937167 556 4307855 SGTC_2738 aclarubicin 5.55 µM -0.0151926461757586 0.495521042036221 no 1697 0.493939244243944 554 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1986 st071812 45 µM -0.0153803917209243 0.495437916076836 no 1698 0.493864353358805 553 11838594 SGTC_3041 9091929 49.47 µM -0.0156673945641808 0.495310843476733 no 1699 0.493749869586053 554 25236887 SGTC_395 anisomycin 6.25 µM -0.0159780048438764 0.495173319048635 no 1700 0.493625969523899 568 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2619 obliquin 87.91 µM -0.0160948320222325 0.495121593313517 no 1701 0.493579368215517 560 6708593 A bioactive alkalod. YER133W GLC7 SGTC_277 nystatin 15.5 µM -0.0167634587126692 0.494825557578157 no 1702 0.493312660760707 567 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1687 st020778 55.3625 µM -0.0168015750768043 0.49480868156995 no 1703 0.493297456672768 551 4259299 SGTC_2298 7976326 193.81 µM -0.0172394997223358 0.494614791245304 no 1704 0.493122775321743 559 2235818 SGTC_669 0108-0021 26.2 µM -0.0191713612518354 0.493759478941999 no 1705 0.492352201906673 571 17201 SGTC_248 streptozotocin 5.23457 mM -0.0194184275157639 0.493650094819967 no 1706 0.492253655074035 560 5300 DNA alkylating agent. SGTC_1852 st056254 31.4 µM -0.020211458918665 0.493298997769002 no 1707 0.491937343429147 565 442583 SGTC_1159 4092-0538 61.2 µM -0.0207947336854564 0.493040769110511 no 1708 0.49170469937112 556 717301 SGTC_2307 7538926 6.34 µM -0.0212144013690491 0.492854974729315 no 1709 0.491537313118444 555 96582 SGTC_3 0833-0587 95.581 µM -0.0214394786590983 0.492755329627856 no 1710 0.491447540689569 541 5382644 SGTC_930 2810-3379 265 µM -0.0219355504514616 0.492535712789457 no 1711 0.491249683215943 577 1015764 SGTC_3212 9128307 49.47 µM -0.0219907883468546 0.492511258459881 no 1712 0.4912276517984 579 27243542 SGTC_873 0591-4978 488 µM -0.0222612060142177 0.49239154245362 no 1713 0.491119797161726 555 3305145 SGTC_997 3996-0078 137 µM -0.0222979218713321 0.492375288110482 no 1714 0.491105153288869 556 735687 SGTC_2804 7954240 19.48 µM -0.0224733593123204 0.492297621016343 no 1715 0.491035181410425 559 828705 SGTC_906 1165-0455 526 µM -0.0227502586198856 0.492175036806109 no 1716 0.490924742806478 575 3252859 SGTC_451 chloral hydrate 100 µM -0.0260975476444327 0.490693243080762 no 1717 0.489589766547015 571 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1140 3229-1848 2.98 µM -0.0274342211016891 0.490101552897515 no 1718 0.489056702010764 562 2849525 SGTC_1610 st001799 48.1 µM -0.0280877857097688 0.489812254662265 no 1719 0.488796067911489 557 621897 SGTC_300 r073-0011 5.04 µM -0.0293244627858654 0.489264858390335 no 1720 0.488302908403876 557 2735780 SGTC_896 0964-0007 44.5 µM -0.0294696847768252 0.489200579394653 no 1721 0.488244998239729 561 6756758 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0296443781974865 0.489123255956493 no 1722 0.488175336083915 565 6708561 SGTC_1086 cerivastatin 2.18 µM -0.0297214949152486 0.489089122403877 no 1723 0.488144584514912 560 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_944 3370-0224 231 µM -0.0299116173174179 0.489004970395844 no 1724 0.488068770358257 564 4580514 SGTC_3225 9130819 49.47 µM -0.0302214447734626 0.488867835568169 no 1725 0.487945222942731 565 4547121 SGTC_784 4579-0127 173 µM -0.030339764573051 0.488815465587097 no 1726 0.487898041807599 560 1948547 SGTC_1572 epiandrosterone 68.9 µM -0.0315100651670543 0.48829748487545 no 1727 0.487431382644679 557 441302 A steroid. SGTC_2683 piperine 63.03 µM -0.0323196337108087 0.487939177414135 no 1728 0.487108575972969 568 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2131 toluylene red 5.2905 µM -0.03391847690937 0.487231573249766 no 1729 0.486471079610985 563 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_998 3996-0085 177 µM -0.0348675402645835 0.486811562697591 no 1730 0.486092681991505 562 715391 SGTC_3348 9149464 3.537 µM -0.035964124227547 0.486326284747657 no 1731 0.485655482578051 564 1951442 SGTC_2445 5742597 35.57 µM -0.036309918091271 0.486173262657607 no 1732 0.485517620831334 569 1774255 SGTC_1195 1502-0147 41.1 µM -0.0367282991911876 0.485988121695993 no 1733 0.485350822184679 565 817940 SGTC_2961 9083290 32.55 µM -0.0375986739630977 0.485602975344005 no 1734 0.485003832600018 562 17741490 SGTC_560 2332-1943 155 µM -0.0384373519795616 0.48523186770803 no 1735 0.484669490200851 566 21177716 SGTC_1788 fluconazole 20 µM -0.0389196743103622 0.485018450096954 no 1736 0.48447721531023 560 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_633 0437-0093 97.7 µM -0.0391250958667253 0.484927556625432 no 1737 0.48439532633805 563 2831118 SGTC_1780 st038448 24.544 µM -0.039341956028809 0.484831602730739 no 1738 0.484308878209726 590 728868 YDL195W SEC31 SGTC_523 1934-0222 13.7 µM -0.0396406029517122 0.484699462170243 no 1739 0.484189828194803 562 1361595 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0399983497749776 0.484541174235054 no 1740 0.48404722096526 570 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3231 9132313 49.47 µM -0.040159240384562 0.484469987694292 no 1741 0.483983086429304 587 4905967 SGTC_2450 5739737 12.93 µM -0.0402965124075667 0.484409251660403 no 1742 0.483928367109018 562 2262825 SGTC_2752 diclazuril 33.15 µM -0.0425556875728724 0.483409732165022 no 1743 0.483027859829754 579 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2245 6637752 200 µM -0.042628039029069 0.483377723635712 no 1744 0.482999021943628 580 681890 SGTC_2278 7948257 134.34 µM -0.0428194852248256 0.483293027707504 no 1745 0.482922715635334 559 1247028 SGTC_1188 1403-0014 4.57 µM -0.0436662370651461 0.482918433206335 no 1746 0.482585226226177 560 9614867 SGTC_391 gliotoxin 8.33 µM -0.0440815455686591 0.482734710390549 no 1747 0.48241970149339 571 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2159 5658611 73.75 µM -0.0444885383308888 0.482554669821712 no 1748 0.482257494009663 589 793844 SGTC_1266 0828-0227 32.9 µM -0.0461385526935004 0.481824793119786 no 1749 0.48159990905366 570 3913820 SGTC_995 3931-2021 34.6 µM -0.046142722101474 0.481822948876368 no 1750 0.481598247470198 575 730143 SGTC_1771 st048882 4.1505 µM -0.0462345203358247 0.481782344100029 no 1751 0.481561664317126 568 4580403 SGTC_2124 5246320 200 µM -0.0464040460103665 0.481707358927198 no 1752 0.481494105869418 588 579342 SGTC_2732 terfenadine 20 µM -0.0467285767465619 0.481563813195935 no 1753 0.481364777133664 570 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_911 3456-4043 236 µM -0.0471645168801327 0.481370992866973 no 1754 0.481191053730856 566 914281 SGTC_2776 terbinafine 19.92 µM -0.0475062750623649 0.481219833126194 no 1755 0.481054864603835 563 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_600 1495-0418 41.6 µM -0.0486838066710072 0.480699031376799 no 1756 0.480585640488547 572 5377768 SGTC_1350 1495-0454 146 µM -0.0501198039591905 0.480063959422862 no 1757 0.480013459146289 566 1069057 SGTC_2976 9009005 19.48 µM -0.0512039565062396 0.479584524768467 no 1758 0.479581499573201 564 2993148 SGTC_2202 7226349 200 µM -0.0516519960493509 0.479386401011473 no 1759 0.479402993873024 570 844334 SGTC_672 1441-0018 53.7 µM -0.0523779178497283 0.479065408136184 no 1760 0.479113784481742 572 251141 SGTC_3303 9125618 40.5795 µM -0.0525576486356645 0.478985935684271 no 1761 0.479042180897716 584 22695467 SGTC_1233 0325-0408 14.2 µM -0.0529423784423371 0.478815820612187 no 1762 0.478888909304661 582 12874 SGTC_2600 tangeritin 87.95 µM -0.0533867582451105 0.47861933504683 no 1763 0.478711877778369 581 68077 A bioactive flavone. SGTC_822 1487-0950 154 µM -0.0536811259256515 0.478489181224183 no 1764 0.478594610223036 570 1958375 SGTC_3114 9122766 49.47 µM -0.0547171751551612 0.478031113377019 no 1765 0.478181893032895 579 17176985 SGTC_2409 alverine citrate 63.97 µM -0.055322849442901 0.477763340356928 no 1766 0.477940629408385 585 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1997 st073024 93.8 µM -0.0553379200591482 0.477756677655066 no 1767 0.477934626298524 575 686268 SGTC_3241 9133421 49.47 µM -0.0558381713541081 0.477535520680668 no 1768 0.477735363011014 571 17018221 SGTC_2681 menadione 3.18 µM -0.0561826227493463 0.47738324557541 no 1769 0.477598162166279 570 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_304 1310-0298 97 µM -0.0568845155944986 0.477072962964017 no 1770 0.477318594552178 573 1550234 SGTC_508 roscovitine 141 µM -0.0569294534697062 0.477053097951176 no 1771 0.477300695938723 572 160355 A CDKinase inhibitor. SGTC_2763 lisinopril 49.32 µM -0.0576325079944991 0.476742316632568 no 1772 0.477020677531846 584 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2771 fluoxetine 41.05 µM -0.0587633835485641 0.476242449178563 no 1773 0.476570286866421 570 3386 A selective serotonin reuptake inhibitor. SGTC_1881 5652484 16 µM -0.0589105063284065 0.476177420979621 no 1774 0.476511694873479 601 2255129 SGTC_1915 st067105 30.6 µM -0.0589710312627134 0.476150669171447 no 1775 0.47648759082346 570 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1933 st074711 15.9 µM -0.0594342076405601 0.475945950408668 no 1776 0.476303133724583 576 17250958 SGTC_2141 5621638 7.665 µM -0.0597001031597313 0.475828430437415 no 1777 0.476197244786869 578 2856238 SGTC_3198 9112019 49.47 µM -0.0611315840627905 0.475195783749581 no 1778 0.475627207868052 581 45595555 SGTC_1199 1638-0010 4.46 µM -0.0612053581562487 0.475163180778933 no 1779 0.475597831271889 574 3111136 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0616305310280458 0.474975287462961 no 1780 0.475428531452772 575 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_64 000l-0018 272.079 µM -0.0616332028948281 0.474974106723362 no 1781 0.475427467554666 572 6811119 SGTC_1435 4092-0789 56.7 µM -0.0621607065591015 0.474740998946154 no 1782 0.475217426785543 569 2248285 SGTC_2712 st079126 47.7 µM -0.0621850942472503 0.474730222054597 no 1783 0.475207716291577 589 3152970 SGTC_2867 9039098 71.43 µM -0.0623504912372709 0.474657133801807 no 1784 0.475141860234237 588 6463460 SGTC_2279 7948423 32.93 µM -0.0628595447476093 0.474432190502303 no 1785 0.474939174858953 573 1247112 SGTC_1279 0874-0590 65.2 µM -0.0637604668009007 0.474034106248396 no 1786 0.474580478548991 581 3523074 SGTC_2072 5231554 129 µM -0.0640342190522282 0.473913150334584 no 1787 0.474471489922399 572 789545 SGTC_2240 6690706 185.951 µM -0.0643359864373693 0.473779818876325 no 1788 0.47435134988124 574 805876 SGTC_870 0573-2213 57.6 µM -0.0652347018960498 0.473382752193421 no 1789 0.473993565921959 570 3916321 SGTC_480 am 92016 50 µM -0.0662059128400491 0.472953685602112 no 1790 0.473606944669871 619 2129 K+ channel blocker. SGTC_72 0744-0168 198.391 µM -0.0662881234520487 0.472917367606515 no 1791 0.473574219270149 614 677577 SGTC_1324 1418-0026 34.4 µM -0.0665182499119375 0.472815706360412 no 1792 0.47348261427921 619 1372513 SGTC_2665 lovastatin 100 µM -0.0679170473680243 0.472197808396486 no 1793 0.472925834124867 582 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2908 7930301 100 µM -0.0696542814105372 0.471430504415962 no 1794 0.472234415749281 586 2223178 SGTC_2152 5568786 200 µM -0.0699199890413695 0.471313155573527 no 1795 0.47212867155523 589 5399883 SGTC_1271 0832-2808 169 µM -0.0699877493146085 0.471283229884875 no 1796 0.472101705178667 600 3663794 SGTC_257 daunorubicin 18.5 µM -0.0700928844386491 0.471236798265208 no 1797 0.47205986508486 581 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1923 st058458 19.1 µM -0.0701650028625331 0.471204948286484 no 1798 0.472031164658563 607 3534982 SGTC_167 3672-0051 66.205 µM -0.0709552467414691 0.470855961494597 no 1799 0.47171668679717 585 3237971 SGTC_45 0kpi-0036 14.9 µM -0.0713248188161126 0.470692759071491 no 1800 0.471569621484748 570 2795021 SGTC_2979 9012552 45.46 µM -0.0713596771109136 0.470677365959178 no 1801 0.471555750382074 576 17100905 SGTC_688 0527-0193 473 µM -0.0729667639829846 0.469967738666198 no 1802 0.470916282742297 577 4007154 SGTC_2239 6685329 187.64 µM -0.073083297788166 0.469916285534679 no 1803 0.470869916273498 596 805680 SGTC_573 3702-0553 84.7 µM -0.0739999643576512 0.469511567639424 no 1804 0.470505206811458 593 1222756 SGTC_3089 9117425 49.47 µM -0.0745990636401972 0.469247076022785 no 1805 0.47026685957799 574 9401657 SGTC_146 3448-8650 53.125 µM -0.0749059694813315 0.46911158783303 no 1806 0.470144763472118 614 2891488 YIL048W NEO1 SGTC_2839 9003951 25.97 µM -0.0756289348868053 0.468792438069375 no 1807 0.469857157835953 569 2990634 SGTC_2504 purpurogallin 52.29 µM -0.075721128668103 0.468751740984669 no 1808 0.469820483002181 580 5281571 An antioxidant. SGTC_44 0929-0055 61.211 µM -0.0765023700579406 0.468406890883987 no 1809 0.469509714234829 576 1379590 SGTC_1252 0493-0875 34.8 µM -0.0766783676319755 0.468329206530283 no 1810 0.469439706997 595 3960963 SGTC_2389 9091542 195.52 µM -0.0772205439033038 0.468089900521737 no 1811 0.469224049385591 578 3626624 YOL127W RPL25 SGTC_2160 5660466 132.927 µM -0.077296057155244 0.468056571361201 no 1812 0.46919401372965 605 2859134 SGTC_3309 9129340 25.759 µM -0.0814378769584666 0.466228852461768 no 1813 0.467546863837847 579 17158987 SGTC_3287 9117173 37.0625 µM -0.0821399826250205 0.465919093971368 no 1814 0.467267699496154 585 2789709 SGTC_2662 daunorubicin 22.37 µM -0.0823496210008211 0.465826608658044 no 1815 0.467184348264365 566 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_888 0916-0002 6.97 µM -0.0825818983835071 0.465724137941244 no 1816 0.467091997550527 590 2802138 YIL048W NEO1 SGTC_2046 4110841 106 µM -0.0829449566200758 0.465563976932831 no 1817 0.466947653480956 592 44119630 YMR134W ERG29 SGTC_2794 7785382 27.27 µM -0.0836738365437665 0.465242452701541 no 1818 0.46665787979596 588 2205081 SGTC_2078 5212016 200 µM -0.0841331116508104 0.465039868452697 no 1819 0.466475299335727 583 1899708 SGTC_1891 st059073 26.2 µM -0.0844034409854827 0.464920631593758 no 1820 0.466367835770036 577 688754 SGTC_893 0958-0369 48.9 µM -0.0844582343184456 0.464896463734843 no 1821 0.466346054167159 584 6819948 SGTC_129 0088-0017 176.636 µM -0.0846361357062356 0.46481799713195 no 1822 0.466275334992491 590 182446 SGTC_549 1661-1316 519 µM -0.0849789330585774 0.464666804062294 no 1823 0.466139069550061 597 2857282 SGTC_3076 9116187 49.47 µM -0.0855674659415727 0.464407239599608 no 1824 0.465905130995325 613 27241210 SGTC_1510 1123-0200 71.5 µM -0.0858534487327373 0.464281116221645 no 1825 0.465791458671122 620 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_805 3852-0218 479 µM -0.0868959382616851 0.463821390714816 no 1826 0.465377114053425 582 6615355 SGTC_882 0843-0131 351 µM -0.0882310242506187 0.463232704266818 no 1827 0.464846529838692 604 5425421 SGTC_414 piperonyl butoxide 100 µM -0.0888019526103515 0.462980986338383 no 1828 0.464619652932672 601 5794 A potent inhibitor of cytochrome P450. SGTC_1023 4482-3888 16 µM -0.0888224005891602 0.462971971255927 no 1829 0.464611527477829 584 3303168 SGTC_278 4092-0821 23.9 µM -0.0891037923946766 0.462847913479066 no 1830 0.464499711745302 610 877900 SGTC_1029 k015-0030 64.7 µM -0.0901529251533871 0.462385412135427 no 1831 0.464082846107763 595 2208316 SGTC_1205 4161-2785 76 µM -0.0909216842652181 0.462046543400494 no 1832 0.463777410001346 641 3498106 SGTC_1397 3532-0190 20.1 µM -0.0915841193743812 0.461754564334191 no 1833 0.463514234659979 586 5322280 SGTC_1251 0490-5699 265 µM -0.0937069815973007 0.460819017859465 no 1834 0.462670962085938 583 3883818 SGTC_2040 5100729 123 µM -0.0958803935050336 0.45986141877423 no 1835 0.46180778327235 596 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_736 0958-0254 92.6 µM -0.0970367517761913 0.459352025140513 no 1836 0.461348604228457 597 6812352 SGTC_3202 9113761 49.47 µM -0.0970661712566961 0.459339066272963 no 1837 0.461336922697653 591 4798415 SGTC_2387 9077560 195.08 µM -0.0973948701799915 0.459194281959501 no 1838 0.46120640918322 581 5303272 SGTC_3061 glucosamine 200 µM -0.0977562724201808 0.459035098834673 no 1839 0.461062915280846 582 91431 and experimental redox chemotherapeutic SGTC_1286 0929-0070 131 µM -0.097757727730829 0.459034457842232 no 1840 0.46106233746344 598 1420408 SGTC_578 3460-0051 92 µM -0.0980420134500486 0.458909246072474 no 1841 0.460949466070256 593 2876744 SGTC_1000 4048-0884 8.67 µM -0.0983105429733728 0.458790977758867 no 1842 0.460842853328055 611 13040088 SGTC_2823 7987624 58.44 µM -0.0984413990851795 0.45873334619305 no 1843 0.460790901293181 607 2239440 SGTC_1821 st053465 65.6 µM -0.0986774267587855 0.458629397228648 no 1844 0.460697196106226 609 675086 SGTC_2471 5466956 24.79 µM -0.0996184701457734 0.45821498043822 no 1845 0.460323614856028 588 724419 SGTC_403 arphamenine a 50 µM -0.100579494413333 0.457791811342016 no 1846 0.459942137617202 583 5487158 An arginine aminopeptidase inhibitor. SGTC_1179 1021-1431 9.29 µM -0.100653706093775 0.45775913559765 no 1847 0.459912680923561 608 2840958 SGTC_2608 thymoquinone 42.66 µM -0.101217840790996 0.457510753844803 no 1848 0.45968876727359 587 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2798 7813637 45.45 µM -0.101634361390304 0.457327375455843 no 1849 0.459523452107226 585 956368 SGTC_2112 5488546 200 µM -0.102220687541438 0.457069253459394 no 1850 0.459290753741044 605 600757 SGTC_189 3970-0742 2.116 µM -0.102713106961171 0.456852486592995 no 1851 0.459095335408315 590 2891807 SGTC_335 4077-0256 27.6 µM -0.102808862771183 0.45681033562809 no 1852 0.459057335533643 619 3121989 SGTC_1448 4255-0083 152 µM -0.10395350579054 0.456306510404016 no 1853 0.458603122796618 640 5399660 SGTC_339 3091-4833 71.4 µM -0.106921858126348 0.455000291879022 no 1854 0.457425486158379 596 3240077 SGTC_2621 lithochol-11-enic acid 100 µM -0.107397986184205 0.454790817415116 no 1855 0.457236626029893 617 6708711 SGTC_951 1171-0579 82.7 µM -0.108019086316768 0.45451758080511 no 1856 0.456990276051935 600 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2904 7225135 42.03 µM -0.108030538807517 0.454512542785752 no 1857 0.456985733749509 603 4446116 SGTC_679 0422-0091 41.4 µM -0.108524712118104 0.454295159964027 no 1858 0.45678973942123 592 627384 YHR062C RPP1 SGTC_2417 cerulenin 830 nM -0.109269033114351 0.453967765066902 no 1859 0.456494553745409 607 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2058 5236698 133 µM -0.109393163513004 0.453913168462968 no 1860 0.456445327967047 602 766665 SGTC_1742 st038235 28.8875 µM -0.110189739219265 0.453562829218234 no 1861 0.456129449818683 597 564103 YBR002C RER2 SGTC_22 0964-0034 14.468 µM -0.110655900399907 0.453357825202197 no 1862 0.455944608759952 593 138402 SGTC_2914 7968218 45.32 µM -0.110903362243375 0.453249003787547 no 1863 0.455846489683861 609 2977111 SGTC_1659 st012954 42.1 µM -0.11149547353059 0.452988636948512 no 1864 0.455611727410484 622 24207262 SGTC_1784 st039334 36.3 µM -0.111505780395804 0.452984104928598 no 1865 0.455607641046919 599 3496984 SGTC_19 0279-0214 38.434 µM -0.111776697973755 0.452864982268171 no 1866 0.45550023202142 587 3566274 YBR002C RER2 SGTC_561 1550-0330 72.9 µM -0.112366764406751 0.452605544314101 no 1867 0.455266303280063 622 6812934 SGTC_358 0075-0058 9.45 µM -0.11239307616501 0.452593976140102 no 1868 0.455255872482181 667 1069125 SGTC_1640 st009078 66.4 µM -0.112547291431919 0.452526174979612 no 1869 0.455194737382866 605 690618 SGTC_2927 9011802 47.9 µM -0.115653866342108 0.45116065835949 no 1870 0.453963435066429 610 43912568 SGTC_2522 biochanin a 4.94 µM -0.117307502437057 0.450434025699711 no 1871 0.453308189998141 622 5280373 A possible chelator. SGTC_2932 9016711 44.54 µM -0.118977543548771 0.44970035302207 no 1872 0.452646573521761 622 7117328 SGTC_2099 5377090 177.372 µM -0.119191616026123 0.449606320332907 no 1873 0.452561774370567 618 2243829 SGTC_201 4262-0159 12.803 µM -0.119557243458119 0.449445722718415 no 1874 0.452416945737346 590 1341029 SGTC_2677 mitomycin C 100 µM -0.119946673338591 0.449274679261605 no 1875 0.452262695682332 599 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1931 st074438 57.1 µM -0.120273316247415 0.449131220053585 no 1876 0.452133320598855 612 2787313 SGTC_76 0433-0009 400.328 µM -0.120964286571325 0.448827772808259 no 1877 0.451859661306027 670 2841569 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.122756772497524 0.448040722798496 no 1878 0.451149852915206 590 16725076 SGTC_2720 fluspirilene 36.88 µM -0.122907081626463 0.447974733872877 no 1879 0.451090338910519 614 3396 An atypical antipsychotic. SGTC_2003 4023581 200 µM -0.122942639574083 0.447959123383113 no 1880 0.451076260113627 609 16641307 SGTC_56 0957-0365 83.25 µM -0.12347845819719 0.447723900479475 no 1881 0.450864115803888 588 6752360 SGTC_647 0140-0236 81 µM -0.123561519631237 0.447687438381726 no 1882 0.450831230910791 612 990837 SGTC_2780 5215298 71.43 µM -0.124081664570084 0.447459116538736 no 1883 0.450625307756113 637 2834131 SGTC_2795 7780010 54.55 µM -0.124298519641703 0.447363931382694 no 1884 0.450539459683791 611 953673 SGTC_1892 st058411 7.36 µM -0.125085738555713 0.447018419418688 no 1885 0.450227836800218 612 3934738 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.126069784926471 0.446586576063518 no 1886 0.44983834237184 618 16486 A toxic proline analog. SGTC_1442 4112-3290 3 µM -0.126122161375868 0.446563592716573 no 1887 0.449817612651811 604 704353 SGTC_622 1348-1566 26.3 µM -0.126861329023384 0.446239257213632 no 1888 0.449525077125704 618 7340407 SGTC_2446 5162541 200 µM -0.127164087974029 0.446106421568544 no 1889 0.449405264113547 600 1549321 SGTC_415 dibenzyl ketone 100 µM -0.12761468157547 0.445908734598474 no 1890 0.449226955959035 602 7593 SGTC_794 k038-0031 316 µM -0.12771503393751 0.445864709272361 no 1891 0.449187246083078 593 6624242 SGTC_548 1436-0017 110 µM -0.128321418085806 0.445598698266408 no 1892 0.44894730802182 617 9677137 SGTC_2968 9090663 33.37 µM -0.128636873153386 0.445460322860778 no 1893 0.448822494066322 661 25236811 SGTC_121 0557-0495 61.343 µM -0.129290814026168 0.445173490722004 no 1894 0.448563769886473 597 3104427 SGTC_1898 st060199 18.6 µM -0.132179738676024 0.443906693445222 no 1895 0.447421063344512 595 688866 SGTC_3188 9110789 49.47 µM -0.132434831674717 0.443794862168287 no 1896 0.447320182805504 629 849217 SGTC_323 4013-0906 34.3 µM -0.132623713387889 0.443712060414564 no 1897 0.447245488756463 600 2910086 SGTC_654 1124-0271 80.9 µM -0.134342472647675 0.442958706017086 no 1898 0.446565884653737 604 5403748 SGTC_1825 st052143 62.6 µM -0.134442498409994 0.442914869754782 no 1899 0.446526338890182 631 674173 SGTC_2244 6635614 200 µM -0.135042353818996 0.442651997968832 no 1900 0.446289193756395 592 836499 SGTC_179 1273-0063 6.77 µM -0.135553715884505 0.442427926128869 no 1901 0.446087048494074 645 3108139 SGTC_2506 ethyl hematommate 54.16 µM -0.135693772334172 0.442366558524307 no 1902 0.446031685570549 612 3940691 An allergen. SGTC_2366 9070441 60.58 µM -0.135759795455521 0.442337630091161 no 1903 0.446005587651249 627 6837235 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.136547929715892 0.441992328045008 no 1904 0.445694068455235 599 688669 SGTC_1375 2910-0797 186 µM -0.137059798005555 0.441768088871751 no 1905 0.445491764528854 609 742508 SGTC_3295 9122362 53.5725 µM -0.137133091405387 0.441735982037296 no 1906 0.445462798193361 627 4730473 SGTC_1862 st057513 3.81 µM -0.137678681020132 0.441496993633727 no 1907 0.445247184502628 606 5393163 SGTC_1439 4092-1168 46 µM -0.138712828937836 0.441044057162938 no 1908 0.444838540042051 606 2886240 SGTC_2300 7976697 71.57 µM -0.140178626854248 0.440402198706604 no 1909 0.444259429227091 597 2236109 SGTC_1214 0358-0031 63.7 µM -0.140179480363392 0.440401825008812 no 1910 0.444259092055275 670 4301366 SGTC_466 geldanamycin 89.2 µM -0.140286074423546 0.440355154614085 no 1911 0.444216983259708 606 5288382 HSP90 inhibitor. SGTC_2892 9047358 58.44 µM -0.14040658894666 0.440302390379629 no 1912 0.444169376098797 623 6466771 SGTC_3078 9116413 49.47 µM -0.140537362230664 0.440245135805609 no 1913 0.444117717304636 607 17177322 SGTC_1418 3966-3099 2.4 µM -0.141495873117647 0.439825523073743 no 1914 0.443739110009684 598 740335 SGTC_169 k015-0017 16.025 µM -0.141580137010445 0.439788637618026 no 1915 0.443705828618469 640 1840002 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.143022738906382 0.439157238171704 no 1916 0.443136111379059 607 6312947 SGTC_362 0310-0100 9.03 µM -0.14458087219804 0.438475446729397 no 1917 0.442520900154187 620 790235 SGTC_2916 7875993 68.79 µM -0.145704402259895 0.437983937511794 no 1918 0.442077372980297 631 1299250 SGTC_1578 josamycin 24.2 µM -0.147027583007347 0.437405210091792 no 1919 0.441555124407477 640 5282165 A P450 substrate. SGTC_176 1486-1328 72.834 µM -0.147426621893656 0.437230706306716 no 1920 0.441397646934074 607 22310231 SGTC_2949 9072542 2.23 µM -0.147649099035261 0.437133420077383 no 1921 0.441309852147837 652 16457352 SGTC_11 0438-0307 1.3 µM -0.147743169190624 0.437092285620503 no 1922 0.441272730688174 619 4011476 SGTC_2268 7933382 153.85 µM -0.148883178318928 0.436593843168001 no 1923 0.440822907511994 601 935025 YOR257W CDC31 SGTC_1369 1866-0067 208 µM -0.148940525757623 0.436568771987943 no 1924 0.44080028145337 624 3531355 SGTC_3166 9102297 49.47 µM -0.149594648672175 0.436282820279377 no 1925 0.440542215207318 626 25237072 SGTC_1871 st057448 67.3 µM -0.150087712592456 0.436067297973497 no 1926 0.440347707052636 613 691747 SGTC_1082 camptothecin 424.86 nM -0.150339757148018 0.435957134547406 no 1927 0.440248283875108 589 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2039 Aminomethylbenzodioxan 200 µM -0.150870444694555 0.435725198327287 no 1928 0.440038957647942 639 15053 SGTC_1051 3253-3903 78 µM -0.151300971644594 0.435537053387313 no 1929 0.439869151422384 600 5509239 SGTC_2829 7992743 58.44 µM -0.152446412421429 0.435036554523155 no 1930 0.439417426505289 598 16462845 SGTC_2716 st080858 38.6235 µM -0.152686539312224 0.434931644557613 no 1931 0.439322738181577 610 5296050 SGTC_1428 4049-0204 61.7 µM -0.154231775134887 0.434256650402696 no 1932 0.438713494496794 618 X1428 SGTC_678 1218-2179 85.9 µM -0.156331921571667 0.433339566234149 no 1933 0.437885697944571 605 6820081 YOR116C RPO31 SGTC_1425 4048-4433 7.33 µM -0.157476612092151 0.43283985778682 no 1934 0.437434619377483 630 23734946 SGTC_1970 st070122 35.8 µM -0.15753034774495 0.432816402411129 no 1935 0.437413446214128 654 102928 SGTC_1522 st012842 45.6 µM -0.158184947793041 0.432530691403571 no 1936 0.437155532170174 614 3491067 YOR116C RPO31 SGTC_593 1203-0218 61.7 µM -0.160086217662839 0.431701051285866 no 1937 0.436406578933233 634 3666956 SGTC_89 0302-0250 142.109 µM -0.16008636731003 0.431700985997466 no 1938 0.436406519992753 609 4203518 YLR208W SEC13 SGTC_263 alizarin 107.927 µM -0.160365360716492 0.431579269396928 no 1939 0.436296637291051 620 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_610 4215-0184 155 µM -0.160483722745872 0.431527633493828 no 1940 0.436250021403265 614 5605015 SGTC_3354 9151612 71.43 µM -0.160811865554651 0.431384486017632 no 1941 0.436120789755668 633 27261949 SGTC_2947 9072639 7.68 µM -0.162260412043332 0.430752686848246 no 1942 0.435550394055593 640 16488146 SGTC_3284 9108171 64.8615 µM -0.162999125927175 0.430430556942892 no 1943 0.435259561438379 610 8687505 SGTC_3032 9089427 49.47 µM -0.163820295275732 0.430072525139193 no 1944 0.434936307102177 607 17173707 SGTC_3294 9122953 26.2835 µM -0.163925338613526 0.430026730133487 no 1945 0.434894959793945 604 16459826 SGTC_1219 1469-0211 33.1 µM -0.164512737387795 0.429770663384655 no 1946 0.434663760186559 635 6822282 SGTC_750 4073-0104 132 µM -0.165201012970481 0.429470658658423 no 1947 0.434392883992796 628 22330957 SGTC_630 4356-0227 183 µM -0.166087772891166 0.429084198882026 no 1948 0.434043938166808 644 779312 SGTC_2566 crystal violet carbinol 226 nM -0.166550622555914 0.428882510854678 no 1949 0.433861824192499 666 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1770 st043884 66.3 µM -0.166658790848707 0.428835378895442 no 1950 0.433819266050712 616 670149 SGTC_1016 4226-1401 38 µM -0.167796393027385 0.428339755300311 no 1951 0.433371730107361 612 2901613 SGTC_1916 st067606 49.2 µM -0.168474320164847 0.428044453818623 no 1952 0.433105072220439 621 19590279 SGTC_1294 1000-1494 117 µM -0.168640960879686 0.427971872166407 no 1953 0.433039529921912 611 712797 YDL207W GLE1 SGTC_1307 1187-1599 12.2 µM -0.169704906030432 0.427508520179481 no 1954 0.432621107793807 622 1538471 SGTC_3037 9091026 49.47 µM -0.170290109913831 0.427253704331899 no 1955 0.432390994405122 647 25236398 YIL048W NEO1 SGTC_1557 sumaresinolic acid 42.3 µM -0.170904070463136 0.426986399566478 no 1956 0.432149597993885 625 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2664 lyso-paf C-16 73.48 µM -0.17109166306038 0.426904732603398 no 1957 0.432075845566703 623 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1055 3448-0672 86 µM -0.171281463156181 0.42682210781177 no 1958 0.432001227665825 651 748378 SGTC_503 tyrphostin 8 294 µM -0.171480825606398 0.426735323742498 no 1959 0.431922853038588 663 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2472 5377652 49.4 µM -0.172468888875028 0.42630526432385 no 1960 0.431534458962453 660 1610903 SGTC_3092 9117248 49.47 µM -0.173097137549376 0.426031861518181 no 1961 0.431287537447634 607 17141857 SGTC_314 1671-0008 2.74 µM -0.17332804121817 0.425931385217993 no 1962 0.431196791776644 642 3913060 SGTC_2263 7948595 193.29 µM -0.173558791686094 0.425830980385948 no 1963 0.43110610994209 643 2971371 SGTC_515 4092-1064 102 µM -0.173821215914396 0.42571679941699 no 1964 0.431002985158969 684 717353 SGTC_2378 9074213 121.43 µM -0.174622764686281 0.42536808358032 no 1965 0.430688029894606 610 657714 SGTC_671 0560-0003 407 µM -0.174945913338609 0.425227513431182 no 1966 0.43056106646092 637 3238678 SGTC_1816 st051957 91.6 µM -0.175692584658257 0.424902746670221 no 1967 0.430267730636069 619 674121 SGTC_1987 st072290 61.9 µM -0.178414158760557 0.423719423487807 no 1968 0.429198865305994 654 54697379 SGTC_1827 berberine 7.24 µM -0.178789305821029 0.423556365600443 no 1969 0.429051571351266 627 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1744 st037937 38.9 µM -0.178920093086514 0.423499521915451 no 1970 0.42900022268103 654 1016152 SGTC_184 1494-0393 24.714 µM -0.179747165178911 0.423140090917228 no 1971 0.42867553198373 636 3090647 SGTC_49 0717-0965 32.132 µM -0.179997165025162 0.423031457952214 no 1972 0.428577396916261 696 5889349 YGL099W LSG1 SGTC_985 1493-0307 8.71 µM -0.180783864201938 0.422689650104291 no 1973 0.428268614458776 648 3278274 SGTC_583 1488-1091 88.9 µM -0.183078823823756 0.421692861349847 no 1974 0.42736808554201 654 4303273 SGTC_2399 5884133 200 µM -0.183887784824678 0.421341617863843 no 1975 0.427050743849304 643 722445 SGTC_59 0330-0160 1.33 µM -0.184247091805807 0.421185630106295 no 1976 0.426909808936229 628 4293482 SGTC_2345 9052315 157.45 µM -0.186398317654789 0.420251967113631 no 1977 0.426066205814479 619 6469265 SGTC_1886 st057356 49.9 µM -0.186489769785234 0.420212285475282 no 1978 0.426030350333328 619 24207747 SGTC_2684 capsaicin 100 µM -0.186669531159502 0.420134288280443 no 1979 0.425959873379849 638 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1819 st053448 58.6 µM -0.186700979783391 0.42012064326619 no 1980 0.425947543926253 617 2857616 SGTC_17 0960-0276 49.807 µM -0.187128933007129 0.419934971309835 no 1981 0.425779771784746 625 6821114 SGTC_3137 9097352 49.47 µM -0.18734189942561 0.419842580252219 no 1982 0.425696286748597 631 44120435 SGTC_2934 9036370 36.88 µM -0.188985152629125 0.419129837904914 no 1983 0.42505222679421 633 6462800 SGTC_817 1391-0715 46 µM -0.189146666447117 0.419059797409625 no 1984 0.42498893351145 636 1353946 SGTC_2751 anetholtrithion 17.25 µM -0.18944300090337 0.418931298593124 no 1985 0.424872812374246 654 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.189684896287681 0.418826412474222 no 1986 0.424778028475006 632 279621 SGTC_830 4076-0286 57.8 µM -0.189871528249215 0.418745492582144 no 1987 0.424704901878499 623 6866659 SGTC_1249 0481-0015 10.2 µM -0.19006122747089 0.418663246310426 no 1988 0.42463057611606 628 4227577 SGTC_3332 9141069 11.198 µM -0.19252802880494 0.41759406130416 no 1989 0.423664307381095 636 17332883 SGTC_2998 9066762 71.4286 µM -0.19296920907705 0.417402904626573 no 1990 0.423491541218972 648 4945196 SGTC_1955 wogonin 32.4 µM -0.19399898673505 0.416956793714777 no 1991 0.423088337650097 620 5281703 A flavanone. SGTC_1430 4049-0248 69.1 µM -0.194132319114446 0.416899040478875 no 1992 0.423036137997943 636 22774488 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.194454617208017 0.416759443705554 no 1993 0.422909963814514 619 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_763 3453-1109 128 µM -0.195015292730954 0.416516623685039 no 1994 0.422690487800594 617 1560353 SGTC_2370 9071495 200 µM -0.196795776620039 0.415745734877292 no 1995 0.421993678129554 666 21791103 SGTC_2952 9073731 13.78 µM -0.1977823693609 0.415318713229028 no 1996 0.421607670447989 646 16457353 SGTC_3008 9078912 71.4286 µM -0.197932450916615 0.41525376298465 no 1997 0.421548957132567 665 16648731 SGTC_3346 9158254 43.5805 µM -0.198868804907828 0.414848592865284 no 1998 0.421182686084486 624 17639500 SGTC_2960 9079389 5.97 µM -0.19892567889183 0.414823985813479 no 1999 0.42116044103645 658 16457355 SGTC_1297 1068-0111 14.1 µM -0.199813112384321 0.414440072907808 no 2000 0.420813372962989 625 767057 SGTC_2719 novobiocin 32.65 µM -0.199903941737224 0.414400783794683 no 2001 0.420777853803519 644 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2846 9008642 19.48 µM -0.200226361341188 0.414261325002297 no 2002 0.420651775616634 697 2992898 SGTC_1401 3807-4679 7.6 µM -0.200453706203464 0.414162996163673 no 2003 0.420562880120251 620 3291456 SGTC_2321 7390090 138.78 µM -0.201059152070772 0.413901161264084 no 2004 0.420326160823431 662 649046 SGTC_2791 5663188 71.43 µM -0.20148943495086 0.413715101700477 no 2005 0.420157944861452 663 54690634 SGTC_2622 2-methoxyxanthone 59.94 µM -0.201771955331988 0.413592946974753 no 2006 0.420047503502866 621 71034 A hepatoprotective. SGTC_2319 6033012 152.6 µM -0.20248643136822 0.413284062798417 no 2007 0.419768232457615 626 847246 SGTC_220 paclitaxel 373.376 µM -0.202538195587355 0.413261686036426 no 2008 0.419748000670069 648 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1143 3454-2408 5.08 µM -0.202572763879707 0.413246742928205 no 2009 0.419734489943083 634 X1143 SGTC_3045 9092950 49.47 µM -0.202587170371584 0.413240515357501 no 2010 0.419728859314555 675 44120432 SGTC_3155 9099265 49.47 µM -0.20339513476063 0.412891287289539 no 2011 0.419413101117559 663 25236499 SGTC_2401 5128683 200 µM -0.203493787215221 0.412848651257723 no 2012 0.419374550591116 682 708373 SGTC_1 0258-0098 57.368 µM -0.20361823580661 0.412794868009785 no 2013 0.419325920784327 608 6790032 YDR047W HEM12 SGTC_1085 doxorubicin 7.67 µM -0.204977629039174 0.412207482571532 no 2014 0.41879480168051 638 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1600 coumarin 106 71.1 µM -0.205370029208498 0.412037965386026 no 2015 0.418641517211483 681 100336 A hepatotoxic, DNA x-linker. SGTC_160 3453-0671 289.699 µM -0.205843386779694 0.411833496381365 no 2016 0.418456624546756 671 5322268 SGTC_3327 9140648 26.9345 µM -0.207006299057913 0.411331272759599 no 2017 0.418002469556741 652 8029710 SGTC_1400 3771-8998 51.5 µM -0.207250972834241 0.411225624660766 no 2018 0.417906930405265 626 670767 SGTC_1088 bifonazole 369 nM -0.20783657120714 0.410972794316948 no 2019 0.417678288184151 625 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2686 alizarin 95.37 µM -0.208242791753284 0.410797431529218 no 2020 0.417519698948649 637 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_270 tamoxifen 5.46 µM -0.208262789093783 0.410788799266539 no 2021 0.417511892297014 655 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_793 0488-0545 106 µM -0.208343263604362 0.410754061228315 no 2022 0.417480476624701 626 292548 SGTC_3341 9147222 25.867 µM -0.208899016789738 0.410514181093372 no 2023 0.417263535858618 669 1939759 SGTC_982 1491-0518 27.5 µM -0.209049011474555 0.410449444515213 no 2024 0.417204989069091 627 3091256 SGTC_1822 st052468 42 µM -0.209161262093894 0.410400999587968 no 2025 0.417161175961561 637 2873678 SGTC_2382 9035899 200 µM -0.20940003500586 0.4102979549374 no 2026 0.417067982719341 664 6462679 SGTC_2945 9067681 61.76 µM -0.209700886245121 0.410168128630586 no 2027 0.416950566895234 656 16456930 SGTC_3159 9100096 49.47 µM -0.210030694190039 0.410025817952003 no 2028 0.416821858397813 616 25236875 SGTC_509 pifithrin 175 µM -0.210710754997661 0.409732412131035 no 2029 0.416556490874749 627 4817 A p53 inhibitor. SGTC_632 0781-2353 4.65 µM -0.212222862977096 0.409080208760637 no 2030 0.415966585442757 646 6811515 YHR007C ERG11 SGTC_112 phenothiazine 287.218 µM -0.212417045572194 0.408996471994613 no 2031 0.415890844375605 667 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3085 9117376 49.47 µM -0.212477762953316 0.408970289876371 no 2032 0.415867162156481 641 16480349 SGTC_965 1291-5240 308 µM -0.212688322833231 0.408879496886286 no 2033 0.415785037707457 663 2834598 SGTC_525 k781-2675 26.7 µM -0.213206198065425 0.408656210954201 no 2034 0.415583067027727 623 3651118 YDL195W SEC31 SGTC_2393 9031399 185.94 µM -0.214968257230969 0.407896707901915 no 2035 0.414896033525235 674 1526623 YDL150W RPC53 SGTC_1210 3013-0140 750 nM -0.215645104903088 0.407605057033153 no 2036 0.414632197126715 665 905973 SGTC_2488 5268135 45.7 µM -0.215717269917852 0.407573964443886 no 2037 0.414604069348189 668 1270356 YLR208W SEC13 SGTC_1484 3473-2379 286 µM -0.21607514831865 0.407419779690346 no 2038 0.414464585453927 647 671917 SGTC_1316 1272-0050 65.9 µM -0.217011472402622 0.407016451085551 no 2039 0.414099702149174 646 7340392 SGTC_1025 k007-0731 70 µM -0.217100639559608 0.406978046800176 no 2040 0.414064957778034 619 6256118 SGTC_572 0960-0087 17.7 µM -0.217304843930651 0.406890099368657 no 2041 0.413985391189648 629 6796365 SGTC_2282 7944268 200 µM -0.217406089440106 0.40684649634981 no 2042 0.413945943001404 677 2970414 SGTC_1446 4239-0190 62 µM -0.217414611500467 0.406842826239135 no 2043 0.413942622599023 665 1340085 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.218574826035077 0.406343244732141 no 2044 0.413490632273769 640 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1650 st011916 45.8 µM -0.218754092745857 0.406266067123317 no 2045 0.413420804691451 656 242528 SGTC_1854 st056233 32.9 µM -0.218913558125788 0.406197417411286 no 2046 0.413358692381998 673 5393174 SGTC_1047 2043-3044 82 µM -0.219159765896726 0.406091430836767 no 2047 0.413262797874071 709 669592 SGTC_1807 st050092 58.9 µM -0.219769716923615 0.405828891121792 no 2048 0.413025252718093 671 5008496 SGTC_1909 st060837 51.5 µM -0.222581818487503 0.404619034647961 no 2049 0.41193049411559 675 678937 SGTC_771 0250-0039 27.3 µM -0.223074576338599 0.404407127897435 no 2050 0.4117387324773 657 3005115 SGTC_2730 imipramine 71.33 µM -0.223956017805198 0.404028140704282 no 2051 0.411395763331352 653 3696 A tricyclic antidepressant. SGTC_3317 9138495 8.753 µM -0.224298495939297 0.403880912063482 no 2052 0.411262523231581 638 17020139 SGTC_3223 9129970 49.47 µM -0.224944034375749 0.40360343723302 no 2053 0.411011406261288 631 17248386 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.225685433896316 0.403284817840033 no 2054 0.410723043947228 644 803109 SGTC_1334 1486-0610 236 µM -0.226976368208197 0.402730186996495 no 2055 0.410221059031695 626 3742339 SGTC_881 0833-0569 170 µM -0.227141154895362 0.402659402893751 no 2056 0.410156991644293 634 5418700 SGTC_1778 st046819 58.9 µM -0.228545989597632 0.402056086084851 no 2057 0.409610903735805 627 671715 SGTC_1975 st070967 30.8 µM -0.228548566314522 0.402054979708348 no 2058 0.409609902274135 652 261391 SGTC_516 3992-2719 87.3 µM -0.228938903424421 0.401887387979645 no 2059 0.40945820144336 643 5350887 YDR037W KRS1 SGTC_3250 9135583 49.47 µM -0.229245889510055 0.401755595788978 no 2060 0.409338903722707 635 7699353 SGTC_1779 st039427 55 µM -0.229580952522887 0.401611762645251 no 2061 0.409208704622925 676 1124498 SGTC_2515 chrysin 20.77 µM -0.230472669536456 0.40122903855233 no 2062 0.408862249220574 650 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_379 3970-0972 5.9 µM -0.231726626722258 0.400691001704112 no 2063 0.408375174539964 646 2898042 YBL034C STU1 SGTC_61 0978-8327 98.565 µM -0.231855027084827 0.400635919426793 no 2064 0.408325307952558 680 6150059 YHR072W ERG7 SGTC_444 curcumin 90.4 µM -0.232665394308078 0.400288326844877 no 2065 0.408010621565848 655 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1563 conessine 56.1 µM -0.232705236608837 0.400271239234264 no 2066 0.407995151306644 635 441082 An anti-amoebic, histamine inhibitor. SGTC_2249 haloperidol 116.36 µM -0.233293266407096 0.400019066572794 no 2067 0.407766843499116 665 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1056 3448-1962 115 µM -0.234695924280029 0.399417714583624 no 2068 0.407222375673737 650 715507 SGTC_3020 9089140 49.47 µM -0.235280728787358 0.399167065699224 no 2069 0.406995425768261 635 17217859 SGTC_1937 st074714 47.2 µM -0.235585366107667 0.399036513731599 no 2070 0.406877215017061 665 17250970 SGTC_1686 st019653 115.5 µM -0.235660569519022 0.399004287134994 no 2071 0.406848034566936 681 97252 SGTC_2460 5552655 174.22 µM -0.236621090575585 0.398592739769109 no 2072 0.406475378437601 642 5401989 SGTC_354 2783-3500 4.88 µM -0.236750231067737 0.398537416483899 no 2073 0.406425281879091 644 6740761 SGTC_2594 a-mangostin 100 µM -0.239747973628316 0.397253770428104 no 2074 0.405262820864787 675 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1835 st008666 49.2 µM -0.239797450130121 0.397232593671628 no 2075 0.405243641904959 658 690455 SGTC_97 0535-0701 19.132 µM -0.240834562168875 0.396788762486616 no 2076 0.404841670571295 638 2832013 YGL099W LSG1 SGTC_1963 st076565 50.3 µM -0.24085309771068 0.396780831431952 no 2077 0.404834487344767 641 4914280 SGTC_1907 st060210 83.7 µM -0.240992954528487 0.396720990367672 no 2078 0.404780288549368 671 688793 SGTC_2291 7917025 104.35 µM -0.24388988196892 0.395482020037328 no 2079 0.403658052812654 659 2964612 SGTC_2666 tannic acid 100 µM -0.244523893585677 0.395211003595398 no 2080 0.403412549552632 653 16134267 A thiamine antagonist. SGTC_381 3461-2219 42.7 µM -0.244841283732999 0.395075350111485 no 2081 0.403289663387019 698 2883159 SGTC_920 mycophenolic acid 780.421 nM -0.245142467864668 0.394946634885014 no 2082 0.403173060647987 647 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_226 1,3-diallylurea 8.28947 mM -0.245349726132028 0.39485806684072 no 2083 0.403092826089568 654 74537 YKL182W FAS1 SGTC_1411 3909-8223 150 µM -0.245561534765818 0.394767559893634 no 2084 0.403010834192348 669 X1411 SGTC_1380 2291-0730 164 µM -0.246398715126863 0.394409883934609 no 2085 0.402686800382795 665 2999191 SGTC_2151 5563267 85.4165 µM -0.247781979635872 0.393819094787346 no 2086 0.402151549197012 672 5310824 SGTC_3128 9127691 49.47 µM -0.248940676775229 0.393324405818549 no 2087 0.401703334999861 700 41316314 SGTC_1015 4130-4525 82 µM -0.249961636461086 0.392888664518855 no 2088 0.401308508345554 656 1363237 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.25217388291511 0.39194494811326 no 2089 0.40045333213748 668 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_368 fentichlor 4.58 µM -0.252810447876867 0.391673515006042 no 2090 0.400207346837523 696 7329 A pesticide. SGTC_47 0149-0135 24.25 µM -0.253367683561313 0.391435951402221 no 2091 0.399992048926996 650 5239155 SGTC_2329 6138490 200 µM -0.253419181437353 0.39141399860335 no 2092 0.399972153340644 691 720019 SGTC_2303 7774051 200 µM -0.25461556212748 0.390904096325272 no 2093 0.399510019205355 696 2953184 SGTC_939 1165-0479 45.3 µM -0.255139003080908 0.390681062590826 no 2094 0.399307870321733 677 1377347 SGTC_1406 3909-7906 11.9 µM -0.255514379353645 0.390521140093186 no 2095 0.399162919500851 655 X1406 SGTC_282 k297-0036 65.7 µM -0.255691698099245 0.390445602980588 no 2096 0.399094453043988 676 5061378 SGTC_268 camptothecin 39.6153 µM -0.255845390898367 0.390380133776731 no 2097 0.399035111567824 669 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.256684359847367 0.390022809289501 no 2098 0.398711223076989 664 4213774 SGTC_2886 9058944 51.95 µM -0.257701763691921 0.38958961243552 no 2099 0.398318542420675 647 4949929 SGTC_449 xestospongin c 11.1929 µM -0.258161875017853 0.389393748232771 no 2100 0.398140990066249 687 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_447 ml7 120 µM -0.25828328171473 0.389342071453696 no 2101 0.39809414395237 666 4216 Selective myosin light chain kinase inhibitor. SGTC_2636 apigenin dimethyl ether 100 µM -0.258479893055345 0.38925838795758 no 2102 0.398018282412668 701 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_689 0833-0039 98 µM -0.259766570209851 0.388710867747121 no 2103 0.39752191951745 704 5374726 SGTC_2336 9001819 198.65 µM -0.261564666102641 0.387946093751942 no 2104 0.396828544082527 672 2989602 SGTC_1070 indatraline 8.81 µM -0.262913747937679 0.387372581431665 no 2105 0.396308529833499 679 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2851 9015922 71.43 µM -0.263442434981847 0.387147896603652 no 2106 0.396104793482704 663 2996893 SGTC_1122 capsaicin 818.572 nM -0.263620797470288 0.387072103488397 no 2107 0.396036065602614 696 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_553 k007-0256 45.7 µM -0.263707846074633 0.387035114735108 no 2108 0.396002524599548 668 6287000 SGTC_173 1273-0061 2.693 µM -0.264845743808542 0.386551692908621 no 2109 0.395564148134552 674 2847414 YPL266W DIM1 SGTC_2505 galangin 7.89 µM -0.264988737261998 0.38649095633587 no 2110 0.395509069067095 686 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3136 9095672 49.47 µM -0.265074018628542 0.386454734337412 no 2111 0.395476220877394 636 17217380 SGTC_1149 3909-7961 23.3 µM -0.265815815347407 0.386139708920594 no 2112 0.395190531197804 644 735261 SGTC_2755 lomerizine 42.69 µM -0.266433497149062 0.385877449747617 no 2113 0.394952685121435 657 3949 A calcium channel blocker. SGTC_1868 st057644 42.7 µM -0.266815512603003 0.385715277348298 no 2114 0.394805604892793 661 688665 SGTC_3018 9082602 49.47 µM -0.267825942562613 0.385286428097022 no 2115 0.394416650356529 664 17332089 SGTC_2002 4023503 131 µM -0.268966679480423 0.384802442187129 no 2116 0.39397766200515 701 4736863 YCR052W RSC6 SGTC_2903 5923464 63.88 µM -0.270191437507592 0.384283008015073 no 2117 0.393506489844362 678 2876576 SGTC_101 0490-5701 117.494 µM -0.270192489289442 0.384282562031263 no 2118 0.393506085284133 676 4661669 SGTC_222 nsc-310342 10.666 µM -0.270859242224516 0.383999871697171 no 2119 0.393249646778251 676 432556 SGTC_1616 st002734 56.1 µM -0.272406149551717 0.383344250833593 no 2120 0.39265487238797 662 4026101 SGTC_1167 k781-0610 148 µM -0.27395988018984 0.382686074187216 no 2121 0.392057726724962 672 4525169 SGTC_1867 st057372 64 µM -0.274975733127993 0.382255931167171 no 2122 0.391667441034599 667 688837 SGTC_2373 9071805 200 µM -0.275002461923015 0.38224461534179 no 2123 0.391657173433489 712 10149009 SGTC_1934 st074720 32.6 µM -0.275759218201958 0.381924278958315 no 2124 0.391366504368498 649 17250992 SGTC_2297 7971671 152.32 µM -0.276309589198365 0.381691356614255 no 2125 0.39115514569835 693 909016 SGTC_1120 ficusin 1.78878 µM -0.276940751538742 0.381424295315611 no 2126 0.390912800339077 674 6199 A DNA cross-linker. SGTC_2498 4'-Methoxychalcone 54.63 µM -0.279897630684925 0.380173915970928 no 2127 0.389778022520325 668 641818 YHR062C RPP1 SGTC_353 1988-1175 58.3 µM -0.280928012364673 0.379738490437717 no 2128 0.389382807360016 688 2788357 SGTC_2551 apiole 73.87 µM -0.281312115030901 0.379576212757633 no 2129 0.389235509456171 658 10659 A possible DNA adduct former. SGTC_1645 Cervolide 78 µM -0.281779325085045 0.379378852030526 no 2130 0.389056362507122 673 23173 A fragrance. SGTC_1606 st000094 49.2 µM -0.28202198216391 0.379276360260677 no 2131 0.388963327418048 687 1242210 SGTC_374 0880-0231 82.3 µM -0.283021557846752 0.37885425613225 no 2132 0.388580155781883 682 6833587 SGTC_1651 st011928 86.1 µM -0.284778771187289 0.378112564704319 no 2133 0.387906818611162 668 720198 SGTC_753 1322-0200 289 µM -0.284814954038244 0.378097297214555 no 2134 0.387892957431313 687 5403907 SGTC_40 0327-0103 19.753 µM -0.285300777234978 0.377892320739908 no 2135 0.387706858721779 665 409036 SGTC_2465 5809242 33.21 µM -0.286494086071393 0.377388990923715 no 2136 0.387249861183596 688 2731748 SGTC_1138 3761-0006 1.03 µM -0.28673815248653 0.377286070933103 no 2137 0.387156411098356 673 12061087 SGTC_2250 alverine citrate 130 µM -0.286949434403898 0.37719698282455 no 2138 0.387075519082544 662 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_581 0958-0271 211 µM -0.288071244397661 0.376724075444237 no 2139 0.38664610183692 667 4591145 SGTC_648 0375-0473 33.3 µM -0.289098743221973 0.376291087869662 no 2140 0.386252907659768 680 1713139 SGTC_2181 6316240 54.2555 µM -0.290795931943006 0.375576234336743 no 2141 0.385603698402361 659 12779990 SGTC_1399 3562-5772 25 µM -0.290930173272425 0.375519710263781 no 2142 0.385552362007383 658 23847490 SGTC_832 4083-0019 164 µM -0.291020175153756 0.375481815286981 no 2143 0.385517944727368 664 1990758 SGTC_2929 9013348 24.6 µM -0.291814046315479 0.375147610687582 no 2144 0.385214402522971 678 2995952 SGTC_979 1426-2828 121 µM -0.293101405856184 0.374605856186549 no 2145 0.384722321110718 680 747872 SGTC_604 1000-0114 314 µM -0.29445247797631 0.374037555856981 no 2146 0.384206085809936 696 1572745 SGTC_1624 st003710 6.25 µM -0.294731665338172 0.373920155589246 no 2147 0.384099435822851 716 24207033 SGTC_524 r073-0010 27.8 µM -0.297541611537618 0.372739206150687 no 2148 0.383026522103871 702 2772106 SGTC_1763 st044482 94.5 µM -0.298295051638374 0.372422757033999 no 2149 0.382738990350882 673 88505 SGTC_2883 9059145 45.46 µM -0.298781947330284 0.372218303872568 no 2150 0.382553213030339 675 16476510 SGTC_821 1114-0266 29.2 µM -0.298799169202256 0.372211072867452 no 2151 0.382546642439422 682 3123235 SGTC_413 propylparaben 100 µM -0.29919160999184 0.372046309654423 no 2152 0.382396925264957 688 7175 A pharmaceutical preservative. SGTC_1213 1315-0166 115 µM -0.300178523440776 0.371632065311612 no 2153 0.38202049296955 682 768401 SGTC_975 1335-0046 28.5 µM -0.300850030905051 0.37135029353287 no 2154 0.381764427752526 716 16486740 SGTC_393 acivicin 6.25 µM -0.301026821323619 0.371276121822675 no 2155 0.381697021050297 695 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3298 9116858 71.43 µM -0.302037694839781 0.370852105790135 no 2156 0.381311663856488 715 2506942 SGTC_183 3914-0051 30.55 µM -0.302237824592617 0.370768178924292 no 2157 0.381235385916631 664 1596232 SGTC_3193 9111931 49.47 µM -0.30243687752259 0.370684709736121 no 2158 0.381159522976147 688 17087244 SGTC_1588 farnesol 29.9 µM -0.302956927166786 0.370466665205024 no 2159 0.380961343507822 654 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3058 9093861 49.47 µM -0.303270907907078 0.370335040636422 no 2160 0.380841707473442 712 17217477 SGTC_838 0109-0203 71.4 µM -0.305472148540142 0.36941268070223 no 2161 0.380003289564219 676 759422 SGTC_704 1310-0270 142 µM -0.306427624283856 0.369012552414387 no 2162 0.379639539082348 719 5718033 SGTC_2703 st077852 53.4 µM -0.306460873312627 0.368998631142038 no 2163 0.379626883062431 709 6281836 SGTC_510 ag-490 170 µM -0.306613069805666 0.368934909103789 no 2164 0.379568952133997 686 5328779 SGTC_1340 1486-1359 257 µM -0.308096831548458 0.368313872731992 no 2165 0.379004326051575 674 4309068 SGTC_2427 5545055 42.75 µM -0.311778609792912 0.366774333348447 no 2166 0.377604390620408 689 5372858 SGTC_2168 5727979 200 µM -0.312862044267534 0.366321700625215 no 2167 0.377192737615738 661 695210 SGTC_3057 9095946 49.47 µM -0.314200567224742 0.365762754869793 no 2168 0.376684355951066 676 24540043 SGTC_846 0335-0850 148 µM -0.314531347884508 0.365624670011914 no 2169 0.376558755734102 684 6819598 SGTC_3046 9092212 49.47 µM -0.314690249584313 0.365558342460795 no 2170 0.376498424058904 662 25236637 SGTC_2517 totarol 10 µM -0.31514894857963 0.365366898336277 no 2171 0.37632428250559 690 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1483 3453-0561 55.9 µM -0.315734060023678 0.365122742979992 no 2172 0.376102185973995 698 4546991 SGTC_2065 5221596 34.26 µM -0.316908453358621 0.364632857084453 no 2173 0.375656533773218 680 788581 SGTC_2376 9072922 81.32 µM -0.317124766020677 0.364542648595225 no 2174 0.375574466725341 719 17087968 SGTC_1801 st050089 28.441 µM -0.317896005945983 0.364221080842767 no 2175 0.375281911183808 678 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1124 fisetin 1.16336 µM -0.318296217165483 0.364054250801437 no 2176 0.375130126744904 706 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2224 6650123 117.647 µM -0.318479243896872 0.363977963778785 no 2177 0.375060718316464 687 2908370 SGTC_2414 st077232 92.9 µM -0.320099142184479 0.363303012358566 no 2178 0.374446587958477 650 729801 SGTC_3175 9106517 49.47 µM -0.320311231173289 0.36321467412008 no 2179 0.37436620503738 696 41468073 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.320490894775135 0.363139847232357 no 2180 0.374298115792545 690 97141 SGTC_1190 1486-1332 13 µM -0.320925347551292 0.36295892650373 no 2181 0.374133482280636 703 4150046 SGTC_2458 5808907 16.39 µM -0.320947449318848 0.362949723402464 no 2182 0.374125107549567 714 2731747 SGTC_1704 st028805 70.8 µM -0.322281425457289 0.362394406977883 no 2183 0.373619751708839 691 2876101 SGTC_2317 5986382 200 µM -0.322407666076713 0.362341869668877 no 2184 0.373571938677385 684 877883 SGTC_2576 guaiol 23.12 µM -0.32316841863289 0.362025323701113 no 2185 0.373283848503788 681 227829 SGTC_4 0960-0234 25.671 µM -0.323230919818816 0.361999321409604 no 2186 0.37326018301104 665 6821112 SGTC_290 2043-6722 48.1 µM -0.323893735913899 0.361723610060033 no 2187 0.373009243296511 695 773758 YLR208W SEC13 SGTC_488 nitrendipine 139 µM -0.324097586043623 0.361638829025352 no 2188 0.372932077220024 675 4507 Dihydropyridine L-type calcium channel blocker. SGTC_932 2857-0803 154 µM -0.325698789591155 0.360973126803622 no 2189 0.372326130053883 712 674898 SGTC_2735 sertaconazole 140 nM -0.32582526756684 0.360920561350579 no 2190 0.372278280145447 676 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2135 5326629 150.42 µM -0.325926607968138 0.360878445208784 no 2191 0.372239941858236 678 5020077 SGTC_3227 9130768 49.47 µM -0.32650774422022 0.360636962897335 no 2192 0.372020115517656 693 17720899 SGTC_1004 4084-0029 199 µM -0.328096092035537 0.359977232888238 no 2193 0.371419504352588 679 716894 YLR208W SEC13 SGTC_745 0469-0705 296 µM -0.328199660682645 0.359934229472297 no 2194 0.37138035219225 705 3486736 SGTC_1992 st073643 23.3 µM -0.328803997624055 0.359683334143765 no 2195 0.371151920638445 705 3161292 SGTC_2170 morpholine 200 µM -0.329236061963851 0.35950399622616 no 2196 0.370988633721231 692 121171 Reacts with secondary amines. SGTC_2707 st078556 66.6 µM -0.329834838001258 0.359255512066099 no 2197 0.370762381074418 679 17250899 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.330035587765302 0.359172216878361 no 2198 0.370686536056491 701 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_100 0086-0128 49.5915 µM -0.330291541975402 0.35906602594365 no 2199 0.370589841603643 730 93297 SGTC_658 3253-0951 102 µM -0.330591391820019 0.358941637326435 no 2200 0.370476574643301 695 1184878 SGTC_1846 st056244 14.8 µM -0.331007823002848 0.358768911341887 no 2201 0.370319288220722 700 5393182 SGTC_24 0417-1663 219 µM -0.331208556497718 0.358685662062416 no 2202 0.370243478746032 711 4329390 SGTC_1011 4112-3381 17.4 µM -0.331617771383317 0.358515971051233 no 2203 0.370088949321429 720 2877139 SGTC_2484 5809818 12.04 µM -0.333191229177975 0.357863758536685 no 2204 0.369494969176541 687 2870548 SGTC_2793 7325131 81.82 µM -0.335577541627883 0.356875402298124 no 2205 0.368594731023435 696 4176441 SGTC_3017 9080681 49.47 µM -0.338052307020253 0.355851424747232 no 2206 0.36766188516783 711 16451914 SGTC_1743 st037606 46.3785 µM -0.338613541272233 0.355619348522727 no 2207 0.367450440097242 669 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1609 st001574 46.4 µM -0.339672514967754 0.355181597641522 no 2208 0.367051581111594 706 3960012 SGTC_2430 5571206 200 µM -0.339696546726578 0.355171665781818 no 2209 0.367042531291155 708 1731771 SGTC_1403 3909-7815 62.9 µM -0.34019285185696 0.354966574505881 no 2210 0.366855650454195 690 6615483 SGTC_1560 lithocholic acid 53.1 µM -0.340199940430002 0.354963645554678 no 2211 0.366852981521295 682 9903 A bile acid which acts as a detergent. SGTC_2540 epiandrosterone 100 µM -0.34122614023646 0.354539717141194 no 2212 0.36646667293749 690 441302 A steroid. SGTC_2869 9037858 32.47 µM -0.341459485429167 0.354443346159434 no 2213 0.366378849985574 669 27187042 SGTC_3234 9132280 49.47 µM -0.342355399090501 0.354073422672274 no 2214 0.366041724528945 688 17612295 SGTC_2519 cryptotanshinone 88.04 µM -0.342730707240098 0.353918498527587 no 2215 0.365900529656429 703 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.343078929043151 0.353774777033675 no 2216 0.3657695411939 712 4174840 SGTC_1562 morin hydrate 59.1 µM -0.343121625587824 0.353757156333637 no 2217 0.365753481372904 713 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_254 nsc-64875 3.808 µM -0.343325717787009 0.353672932595355 no 2218 0.365676717657764 711 56993 SGTC_1156 4092-0367 4.88 µM -0.343922752557681 0.353426592435606 no 2219 0.365452190201297 689 1357585 SGTC_535 2293-4129 48.2 µM -0.34589321843959 0.352614002406844 no 2220 0.364711482674219 735 396118 YIL048W NEO1 SGTC_3010 9080089 71.4286 µM -0.348058758329096 0.35172174201437 no 2221 0.363898028081749 708 17027233 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.348336956158549 0.351607176118996 no 2222 0.363793571336212 683 688662 SGTC_809 3998-0021 90 µM -0.348710273031936 0.351453460001212 no 2223 0.363653415531832 735 715485 SGTC_223 busulfan 5 mM -0.34981919793806 0.350996994898159 no 2224 0.363237195199118 697 2478 A DNA alkylator. SGTC_936 3005-4620 401 µM -0.350149410030508 0.350861111688161 no 2225 0.363113285618793 734 777207 SGTC_3096 9117468 49.47 µM -0.350471147914915 0.350728733983229 no 2226 0.362992569699875 728 41316311 SGTC_1716 st033144 30.6155 µM -0.350849809743705 0.350572958374096 no 2227 0.362850513378226 725 674617 SGTC_1866 st057638 64 µM -0.351817201450992 0.350175102549921 no 2228 0.362487678697793 697 688802 SGTC_2190 6049624 200 µM -0.352696614954272 0.349813571829245 no 2229 0.362157948682009 715 2265554 SGTC_1183 1254-0324 198 µM -0.354058727218008 0.349253870353946 no 2230 0.361647436031004 689 5799357 SGTC_608 k048-0125 159 µM -0.356121069433795 0.34840706344484 no 2231 0.36087494955037 724 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3236 9132701 49.47 µM -0.357822058745082 0.347709197558567 no 2232 0.360238240805625 723 24282524 SGTC_559 1550-0661 158 µM -0.358210294348333 0.347549988108589 no 2233 0.360092971972094 706 5830875 SGTC_2984 9022109 38.96 µM -0.358644703969862 0.347371875278336 no 2234 0.35993044983167 723 6459207 SGTC_1064 honokiol 6.76 µM -0.358706292402867 0.347346626054743 no 2235 0.359907410300498 706 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_783 0848-0141 92.7 µM -0.359049639184603 0.347205877631025 no 2236 0.359778977511172 685 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3211 9128781 49.47 µM -0.359766673410407 0.346912011181531 no 2237 0.359510813731796 713 17194361 SGTC_2048 5246248 200 µM -0.360047363568301 0.346796999307962 no 2238 0.359405857192502 684 677046 SGTC_2799 7812892 81.82 µM -0.363478256130048 0.345392345896755 no 2239 0.358123826467542 715 20205235 SGTC_2451 5856223 45.7 µM -0.36453604129765 0.344959702474428 no 2240 0.357728882713159 689 2179896 SGTC_1063 disulfiram 1.84 µM -0.367100247628925 0.343911761407909 no 2241 0.356772121294282 702 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_209 4077-0173 175.592 µM -0.36710199325181 0.343911048413061 no 2242 0.356771470270238 690 15993494 SGTC_1662 st014054 52 µM -0.367140821907093 0.343895189099522 no 2243 0.356756989364803 705 2838777 SGTC_1928 4'-methoxychalcone 40.3 µM -0.367202459448273 0.343870014207871 no 2244 0.356734002451217 736 641818 SGTC_1777 st045864 34.765 µM -0.367604918537084 0.343705653094659 no 2245 0.356583923398318 717 4691462 SGTC_957 1187-1561 14.1 µM -0.368286789526744 0.343427249801597 no 2246 0.356329700902969 709 1538454 SGTC_3101 9120531 49.47 µM -0.369219675865593 0.343046496248021 no 2247 0.355981995585464 763 24824904 SGTC_210 3551-0445 56.827 µM -0.369911430398433 0.342764262446327 no 2248 0.355724242196284 737 2865180 YOR207C RET1 SGTC_790 1575-0012 79.1 µM -0.370012845819778 0.342722892625165 no 2249 0.355686459522258 721 378741 YLR208W SEC13 SGTC_1288 0973-0013 65.5 µM -0.37042928555739 0.342553036488806 no 2250 0.355531328292029 700 4315430 SGTC_289 k017-0060 526 µM -0.370622684567394 0.342474164328803 no 2251 0.355459291846651 711 5512909 SGTC_1371 2421-0008 32.7 µM -0.372051348997165 0.341891738082506 no 2252 0.354927309064148 719 2827552 SGTC_2391 6285546 200 µM -0.373091960950444 0.341467746534148 no 2253 0.354540000830808 691 846083 SGTC_2060 5238662 140 µM -0.373603989910619 0.341259196561827 no 2254 0.354349482524073 727 790130 SGTC_2897 9048598 12.99 µM -0.374648387985588 0.340833962378347 no 2255 0.353960990663489 695 6467404 SGTC_3345 9148410 3.559 µM -0.374980023824196 0.340698976725315 no 2256 0.353837661597827 729 4903596 SGTC_2197 6588183 93.1375 µM -0.37722660484643 0.339785089288625 no 2257 0.353002605230325 692 884136 SGTC_1454 4239-0054 42.6 µM -0.378427556750269 0.339296939234391 no 2258 0.352556500146466 732 1340767 SGTC_2204 7233102 200 µM -0.378654756312821 0.339204619891391 no 2259 0.352472127477409 708 2172480 SGTC_963 1269-2853 151 µM -0.378689253074473 0.339190603461962 no 2260 0.352459317418973 675 3668223 SGTC_2654 protoveratrine a 100 µM -0.378813347682359 0.339140184241493 no 2261 0.35241323739973 718 5702278 A heart drug and vasodilator. SGTC_2105 5350118 200 µM -0.380043918830297 0.3386403633738 no 2262 0.351956407067622 708 2133313 SGTC_682 0kpi-0099 17 µM -0.380551623028245 0.338434231969528 no 2263 0.351767992015998 719 1714895 YML126C ERG13 SGTC_472 calcifediol 10 µM -0.381415402038951 0.338083642988982 no 2264 0.351447517043862 698 5283731 A vitamin D metabolite. SGTC_2320 7373003 200 µM -0.382891657262349 0.337484788420045 no 2265 0.350900048703097 723 5415828 SGTC_1343 1487-0095 224 µM -0.384202493388817 0.336953382139726 no 2266 0.35041418521133 747 4560101 YGL055W OLE1 SGTC_1999 st074831 12.5 µM -0.384572052973151 0.33680362330011 no 2267 0.350277251539948 757 17112523 SGTC_3307 9126885 69.2785 µM -0.385791395219104 0.336309685566273 no 2268 0.349825584268599 713 24824909 SGTC_707 0865-0008 204 µM -0.386888207143523 0.335865624301168 no 2269 0.349419485986939 711 723043 SGTC_746 1095-0025 46.6 µM -0.387350013182341 0.335678723470434 no 2270 0.349248552275312 730 6749286 SGTC_741 4582-0002 126 µM -0.389241333605298 0.334913698124884 no 2271 0.348548814907473 680 2912688 SGTC_94 0334-0113 514.748 µM -0.390488384436548 0.334409649390841 no 2272 0.348087721419928 703 6795178 SGTC_2910 7948405 25.97 µM -0.390999987379942 0.334202949520751 no 2273 0.347898622593199 717 2971328 SGTC_2926 9010726 65.15 µM -0.391601460059042 0.333960004412981 no 2274 0.347676354464739 747 2994293 SGTC_448 monastrol 171 µM -0.394940371247866 0.332612628478824 no 2275 0.346443447422204 727 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1477 0139-0234 16 µM -0.394999917874091 0.332588618730564 no 2276 0.346421474290983 697 620880 SGTC_1682 st012968 530 nM -0.395627477557669 0.332335622657567 no 2277 0.346189931714362 701 24207270 SGTC_2647 atorvastatin 60.16 µM -0.395793877057816 0.332268552728582 no 2278 0.346128547081776 718 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1121 fusaric acid 630.51 nM -0.395937295678086 0.332210749913637 no 2279 0.346075643319703 699 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1865 st057639 52.2 µM -0.397137085180027 0.33172734846648 no 2280 0.345633186910247 700 688818 SGTC_1191 1487-1166 10.6 µM -0.397603814072896 0.331539376579485 no 2281 0.345461124307175 754 3955771 SGTC_1071 trifluoperazine 6.31 µM -0.39835920411082 0.33123523827962 no 2282 0.345182712586313 752 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2052 5265182 7.135 µM -0.399010249908469 0.330973200776819 no 2283 0.344942825896616 732 1239884 SGTC_1521 st012942 49.4 µM -0.39924820133425 0.3308774490589 no 2284 0.344855164997226 717 24207259 SGTC_1437 4092-1038 11.6 µM -0.399270079416849 0.330868645867814 no 2285 0.34484710556688 725 3977136 SGTC_895 0964-0006 13.7 µM -0.399598568189698 0.330736481480228 no 2286 0.344726105604604 724 6738897 SGTC_2870 9038528 12.99 µM -0.39983746163344 0.330640378186137 no 2287 0.344638118362357 733 6463316 SGTC_1367 1812-0510 76.9 µM -0.400848379068833 0.330233824718226 no 2288 0.344265878754709 711 1142582 YDR527W RBA50 SGTC_2290 7904846 200 µM -0.40105544149944 0.330150576599554 no 2289 0.344189652908593 702 2962154 SGTC_2997 9067075 71.4286 µM -0.401660475729396 0.329907374669348 no 2290 0.343966958073139 730 27209819 SGTC_3067 9117431 49.47 µM -0.40224163864147 0.329673835825217 no 2291 0.343753100500336 727 17150885 SGTC_1575 cyproterone acetate 48 µM -0.402414647008749 0.329604325672204 no 2292 0.343689446163549 765 9880 An androgen receptor antagonist and liver toxin. SGTC_1668 st014914 51.6 µM -0.402422581439398 0.329601137970489 no 2293 0.343686526983721 717 2839556 SGTC_666 0272-0154 136 µM -0.40310739486534 0.329326057029244 no 2294 0.343434610388129 716 6870312 SGTC_1756 st041558 35.5 µM -0.403867469332764 0.329020852813374 no 2295 0.343155089561235 757 3955792 SGTC_1311 1190-0148 100 µM -0.404191777895391 0.32889066295284 no 2296 0.343035849723125 722 1961333 SGTC_474 dl-dihydrosphingosine 5 µM -0.404454741979634 0.328785114350526 no 2297 0.342939176130831 707 3058739 A sphingolipid protein kinase C inhibitor. SGTC_877 0771-0151 33.1 µM -0.405698936186825 0.328285904570753 no 2298 0.34248191201117 728 6166523 SGTC_1706 st031321 9.9705 µM -0.406186906778825 0.32809019906642 no 2299 0.342302636861881 717 6103185 SGTC_3247 9135149 49.47 µM -0.406477080603593 0.327973844308832 no 2300 0.342196046962099 733 8934436 YOR116C RPO31 SGTC_1503 4585-0012 61.3 µM -0.408005498978867 0.327361250362897 no 2301 0.341634818878177 740 2922052 SGTC_14 0354-0009 295 µM -0.408215533393454 0.327277104313946 no 2302 0.341557722541553 729 1713507 SGTC_2440 5628896 157.78 µM -0.409502648337953 0.326761639515451 no 2303 0.341085411834445 727 5522048 SGTC_1664 st014217 9.02 µM -0.409533263290308 0.326749382835371 no 2304 0.341074180613132 725 3982782 SGTC_1300 1094-0077 113 µM -0.409602010458101 0.326721860624183 no 2305 0.341048960944736 699 5532636 SGTC_924 2046-0044 21.3 µM -0.41279929511213 0.325442904836729 no 2306 0.339876833966584 715 3623589 SGTC_2859 9028643 45.46 µM -0.41318873709279 0.32528726288901 no 2307 0.339734169665072 721 17151580 SGTC_2649 anisomycin 9.56 µM -0.415103786638656 0.324522349914392 no 2308 0.339032963776485 732 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1126 isoteolin 1.0172 µM -0.418821717226594 0.323039440593806 no 2309 0.337673215974747 710 133323 SGTC_2019 4016004 108 µM -0.419083192581832 0.322935255685512 no 2310 0.337577666810877 724 45595336 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.420110320260757 0.322526130992029 no 2311 0.337202431908573 736 756377 SGTC_819 1013-0258 27.7 µM -0.420172138612344 0.322501514403133 no 2312 0.337179853311804 742 5753198 SGTC_116 0155-0182 31.788 µM -0.420253797402339 0.322468998377195 no 2313 0.337150029072405 734 771486 SGTC_2348 9022543 33.42 µM -0.421022187647851 0.32216309666461 no 2314 0.336869440056341 716 3162678 YDL140C RPO21 SGTC_1696 st025591 34.7925 µM -0.421501620714329 0.321972291889024 no 2315 0.336694413982309 725 2787147 SGTC_1754 st042065 16.137 µM -0.422836462235295 0.32144129896484 no 2316 0.336207291347179 739 1126236 YIL048W NEO1 SGTC_1026 k007-1105 30.6 µM -0.42387346191016 0.321029037585798 no 2317 0.335829049570211 697 7066794 SGTC_1128 3448-9350 235 µM -0.424608310375253 0.320737030512683 no 2318 0.335561116933965 692 619386 SGTC_764 1951-2361 146 µM -0.425612160464133 0.320338309358929 no 2319 0.335195238894815 731 5438930 SGTC_2583 asiatic acid 100 µM -0.426292945046272 0.320068025156281 no 2320 0.334947199001664 749 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_546 peri-Naphthalide 147 µM -0.426937463779195 0.319812227140558 no 2321 0.334712438682763 721 223824 A penicillin ester. SGTC_2691 st077356 60.2 µM -0.427403034393908 0.319627503732045 no 2322 0.334542898828046 739 2839272 SGTC_2476 5806916 10.51 µM -0.427612041846717 0.31954459086158 no 2323 0.334466798693839 712 2870194 SGTC_2860 9025725 38.96 µM -0.428350003052792 0.31925191518302 no 2324 0.334198159598061 751 40546248 SGTC_3156 9099931 49.47 µM -0.429447431412995 0.318816882973961 no 2325 0.333798821173837 700 18111053 SGTC_1327 1436-0082 2.18 µM -0.429874643204541 0.318647599144519 no 2326 0.333643415795604 726 15992205 SGTC_564 3555-0129 330 µM -0.430312443778284 0.318474158741143 no 2327 0.333484188179268 720 563260 SGTC_2154 5570129 200 µM -0.43069718870967 0.318321769855102 no 2328 0.333344281606536 761 673366 SGTC_1273 0849-0096 14.1 µM -0.43209614809407 0.317767932480368 no 2329 0.332835767071086 750 5286025 SGTC_15 0266-0086 27.098 µM -0.432202497016171 0.317725846401716 no 2330 0.332797122343394 753 1712902 YIL048W NEO1 SGTC_1685 st024049 53.0905 µM -0.432351718652655 0.31766679802445 no 2331 0.332742901662013 743 1941139 SGTC_1481 3346-2004 36 µM -0.432631355306237 0.317556155712178 no 2332 0.332641303230815 757 2770522 SGTC_3192 9110362 49.47 µM -0.43308244664039 0.317377709207111 no 2333 0.332477437275939 726 16649480 SGTC_3290 9121031 71.43 µM -0.433787821228068 0.317098756267919 no 2334 0.332221263139413 696 17014854 SGTC_2815 7968870 71.43 µM -0.435434390002929 0.316447995893821 no 2335 0.331623576357966 753 2977326 YHR190W ERG9 SGTC_1602 st001878 87.6 µM -0.435503490076713 0.316420698420221 no 2336 0.331598503129892 773 595405 YLR310C CDC25 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.436619203505542 0.315980082605197 no 2337 0.331193766725655 751 364106 SGTC_81 0411-0046 9.971 µM -0.437531240216455 0.31562009653426 no 2338 0.330863062530221 746 12925265 SGTC_3167 9103034 49.47 µM -0.43808412781118 0.315401953774959 no 2339 0.330662649900706 725 5127859 SGTC_2913 7966556 36.57 µM -0.439219243352839 0.314954293637748 no 2340 0.330251341419151 752 2976516 SGTC_862 0452-0056 10.2 µM -0.442040333730016 0.313842906550176 no 2341 0.329230009720075 738 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2132 5317594 122.667 µM -0.442256861056008 0.313757673768235 no 2342 0.329151671897706 739 794577 SGTC_709 3807-1509 243 µM -0.443666761535237 0.313202930497467 no 2343 0.32864176496924 771 1886677 YPL242C IQG1 SGTC_2555 cholic acid 100 µM -0.445632811879015 0.312430068441962 no 2344 0.327931252477668 742 6708657 Influences liver metabolism. SGTC_392 N-ethylmaleimide 8.33 µM -0.445831373413485 0.312352058905787 no 2345 0.327859528725398 719 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_291 SEC14.278 35.5 µM -0.446638443950207 0.312035068986543 no 2346 0.327568066701598 729 1068044 SGTC_907 3448-6986 75.5 µM -0.447119656899009 0.311846131066798 no 2347 0.32739433348071 761 590582 SGTC_164 4100-3994 89.624 µM -0.448764742008548 0.311200597899534 no 2348 0.326800687784833 773 4615967 SGTC_2690 usnic acid 100 µM -0.448779662004892 0.311194745929239 no 2349 0.326795305755126 769 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.450423590732691 0.310550251355554 no 2350 0.32620251896641 741 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3319 9138450 16.7555 µM -0.450471813834399 0.310531354477492 no 2351 0.326185136742055 747 2029690 SGTC_2706 st078239 82.5 µM -0.454301204348921 0.309032355422013 no 2352 0.324806024678368 749 15434492 SGTC_2721 ifenprodil 61.44 µM -0.454547361724174 0.308936106465924 no 2353 0.324717455686408 719 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2728 chlorpromazine 9.18 µM -0.454593103062628 0.308918222783346 no 2354 0.324700998753052 779 2726 A thorazine and dopamine antagonist. SGTC_1922 5578187 25 µM -0.454610122513712 0.308911568732935 no 2355 0.324694875539647 695 1350412 SGTC_38 0929-0051 58.268 µM -0.454661489580956 0.308891486264875 no 2356 0.3246763951184 749 1379719 SGTC_2097 5376186 200 µM -0.454871685743523 0.30880931392815 no 2357 0.324600776967709 721 742755 SGTC_2884 9058502 51.95 µM -0.456116822180032 0.308322747024959 no 2358 0.324152987000918 747 6471554 SGTC_2512 diallyl trisulfide 49.23 µM -0.457180846300055 0.307907220719437 no 2359 0.323770532119439 759 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1615 st002656 86.5 µM -0.45839051662478 0.307435115205043 no 2360 0.323335951837547 729 1584458 SGTC_843 0310-0051 143 µM -0.459497218593579 0.307003475027658 no 2361 0.322938574476051 772 2065037 SGTC_2616 abietic acid 100 µM -0.461226573061693 0.306329520944321 no 2362 0.322318029361316 761 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2326 6164455 177.58 µM -0.462751245848978 0.305735877143913 no 2363 0.321771340618418 740 2888790 SGTC_3169 9102970 49.47 µM -0.46324351938246 0.305544315295928 no 2364 0.321594912647717 731 17027839 SGTC_2193 5925765 200 µM -0.464236862419827 0.305157930842033 no 2365 0.321239026805271 736 877370 SGTC_1559 coumarin 343 70.1 µM -0.465229247822454 0.304772135604452 no 2366 0.320883647895791 767 108770 A hepatotoxic, DNA x-linker. SGTC_993 3909-8757 62.7 µM -0.465329822212056 0.304733048864606 no 2367 0.320847640779548 732 4288324 YLR208W SEC13 SGTC_1433 4060-0023 7.6 µM -0.465827261247302 0.304539759366057 no 2368 0.320669575045178 729 3840627 SGTC_2845 9003024 42.97 µM -0.465974045234904 0.304482734050577 no 2369 0.320617039405479 728 2990173 SGTC_2367 9070478 135.38 µM -0.467272091838708 0.30397865223794 no 2370 0.320152610417216 732 572802 SGTC_1104 tacrolimus 29.8 µM -0.467733466936999 0.303799572072715 no 2371 0.31998760250759 736 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_720 r052-1644 49.9 µM -0.468480804952014 0.303509596917246 no 2372 0.319720397312888 762 1422863 YOR257W CDC31 SGTC_3267 9137951 49.47 µM -0.469274779205546 0.30320166190751 no 2373 0.319436620151039 747 16643986 SGTC_614 0462-0418 107 µM -0.469964514848283 0.302934268255221 no 2374 0.319190185083124 739 5188303 SGTC_1752 st044819 83.042 µM -0.470503037826631 0.302725569463121 no 2375 0.318997832180022 733 441209 YML126C ERG13 SGTC_3011 9081274 71.4286 µM -0.47113755919682 0.302479750210084 no 2376 0.318771252528842 743 6625322 SGTC_284 0988-0104 32.6 µM -0.471621774687263 0.302292221027878 no 2377 0.318598390786147 757 4666532 SGTC_1525 8-methoxypsoralen 92.5 µM -0.471751927722758 0.302241823663272 no 2378 0.318551933738571 790 4114 Related to psoralen; DNA damaging agent. SGTC_232 clozapine 119 µM -0.471859648273628 0.302200115372133 no 2379 0.318513485937791 743 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_16 erodoxin 22.806 µM -0.472109652988308 0.302103326070078 no 2380 0.31842426136459 766 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2403 6032726 181.2 µM -0.472261429824031 0.30204457247283 no 2381 0.318370098629405 737 2881040 SGTC_356 1634-0012 32.5 µM -0.473148292998271 0.301701365798433 no 2382 0.318053692308908 780 735457 SGTC_2447 5741742 33.78 µM -0.473580491798152 0.301534173006081 no 2383 0.317899544767622 735 1776504 SGTC_1635 st007035 42.4 µM -0.474247417306703 0.301276259815369 no 2384 0.317661741769337 750 3716403 SGTC_1850 st056238 17 µM -0.475341750273298 0.30085327517037 no 2385 0.317271702753996 764 5393177 SGTC_2243 6634756 200 µM -0.476987787559607 0.300217549226157 no 2386 0.316685408988906 724 885676 SGTC_1806 st050005 60.3 µM -0.477313578342381 0.3000917956454 no 2387 0.316569421714584 731 5194765 SGTC_2122 5258151 111.688 µM -0.478597684663439 0.299596369348217 no 2388 0.316112432903894 751 2173356 SGTC_1800 st050079 29.0735 µM -0.479192132404512 0.299367148608608 no 2389 0.315900975390289 751 3645560 SGTC_2698 st077697 67.5 µM -0.479526474908366 0.299238260145707 no 2390 0.315782069217233 753 3154499 SGTC_2368 9071271 200 µM -0.480820906507071 0.298739496588266 no 2391 0.315321895076657 767 27209959 SGTC_1012 4112-3522 18 µM -0.483300180156121 0.297785252552667 no 2392 0.314441306078833 740 3112398 SGTC_3343 9148379 18.9835 µM -0.485034982582675 0.297118374866338 no 2393 0.313825765385271 765 1955036 SGTC_1097 itavastatin 7.23 µM -0.485239646358688 0.297039744846011 no 2394 0.313753180923467 743 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_636 0kpi-0074 126 µM -0.486389783451795 0.296598049428071 no 2395 0.313345416390907 750 616434 SGTC_213 1246-0773 967 nM -0.486847575753258 0.296422323907629 no 2396 0.313183176153864 755 6251622 SGTC_1250 0485-0349 40.2 µM -0.487442313902326 0.296194102439554 no 2397 0.312972456713956 756 6842794 YDL195W SEC31 SGTC_3134 9127454 49.47 µM -0.488957646202221 0.29561298200227 no 2398 0.312435841217032 763 24262820 SGTC_372 0155-0182 15.9 µM -0.4906059987257 0.294981444958299 no 2399 0.311852571415065 745 771486 SGTC_2001 4023502 57.655 µM -0.49143567588852 0.294663804223156 no 2400 0.311559168330636 749 108941 YCR052W RSC6 SGTC_3040 9091894 49.47 µM -0.491821783856871 0.294516037143425 no 2401 0.311422667718493 725 25236966 SGTC_1038 k292-0204 154 µM -0.492762649181411 0.294156102581693 no 2402 0.311090152497837 771 4454212 SGTC_1661 st013063 9.66 µM -0.493258573176331 0.293966465254959 no 2403 0.310914947902613 765 721395 SGTC_2360 9040895 200 µM -0.49434049883904 0.293552941941278 no 2404 0.310532864012361 742 4914414 SGTC_1614 st002383 48.6 µM -0.494829167666474 0.293366255948471 no 2405 0.310360356739661 743 1947235 SGTC_663 1486-0733 13.9 µM -0.495144235755473 0.293245919765534 no 2406 0.310249155190029 765 722445 YPR165W RHO1 SGTC_2212 7123476 200 µM -0.497877029055295 0.292203125977548 no 2407 0.309285359453958 749 1085715 SGTC_110 0850-0284 111.64 µM -0.49827405113644 0.292051771828357 no 2408 0.309145447441976 753 3906265 SGTC_652 0437-0092 114 µM -0.498824282457953 0.291842071072988 no 2409 0.308951589701058 737 3091274 SGTC_803 4488-1585 147 µM -0.499693885121109 0.291510796592281 no 2410 0.308645319407275 763 747204 SGTC_1268 0828-0275 2.46 µM -0.499880176077378 0.291439852008205 no 2411 0.308579725838102 763 745337 SGTC_2273 7815444 169.05 µM -0.500089755626049 0.291360048133604 no 2412 0.308505939591271 821 2824616 SGTC_2810 7959871 45.46 µM -0.501573355161708 0.290795413668571 no 2413 0.307983832977858 749 2974535 SGTC_2889 9059656 51.95 µM -0.502684458656258 0.290372880624595 no 2414 0.307593069035979 754 3949838 SGTC_1769 st044406 64.4 µM -0.503076144736168 0.290223997883843 no 2415 0.307455368972667 772 670903 SGTC_1757 st041620 31.8375 µM -0.503421490182472 0.290092759228907 no 2416 0.307333982798365 761 5289815 SGTC_206 4546-0025 72.014 µM -0.505137896189226 0.289440901253341 no 2417 0.306730993033126 799 6620745 YIL048W NEO1 SGTC_2617 dihydrotanshinone i 20.83 µM -0.505659154007219 0.289243073856804 no 2418 0.306547973589718 760 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1050 3232-1156 69.3 µM -0.505899278340046 0.28915196342829 no 2419 0.306463679479141 779 700529 SGTC_3152 9099253 49.47 µM -0.507862708755926 0.288407485357335 no 2420 0.305774814275566 767 25236131 SGTC_1102 cgs 12066b 26.1 µM -0.508097306232752 0.288318593000587 no 2421 0.305692552150004 737 6438352 A 5-HT1B full agonist. SGTC_3113 9123498 49.47 µM -0.508694454433051 0.288092383277214 no 2422 0.305483205059522 777 8897275 SGTC_2528 xanthyletin 44.79 µM -0.508897998061759 0.288015296691211 no 2423 0.305411861645161 774 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1936 st074407 74.3 µM -0.509099381472318 0.287939037811972 no 2424 0.305341282674176 749 809813 SGTC_2489 cantharidin 73.42 µM -0.509327146616199 0.287852800317981 no 2425 0.305261466400182 765 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3197 9113331 49.47 µM -0.510784715882516 0.287301217705197 no 2426 0.304750906321848 756 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2296 7971656 126.45 µM -0.510955802076148 0.287236506992618 no 2427 0.304691002833419 760 666570 SGTC_518 1021-0119 62.6 µM -0.511267462895601 0.287118643828966 no 2428 0.304581892522997 782 1097762 SGTC_2018 5133068 143 µM -0.512328708995797 0.286717476082465 no 2429 0.304210487989755 792 785362 SGTC_1707 st032323 6.317 µM -0.512747977401106 0.28655905928646 no 2430 0.304063812149267 766 3132057 YMR211W DML1 SGTC_446 go6976 132 µM -0.513178315283983 0.286396503179941 no 2431 0.303913296578269 769 3501 A protein kinase C inhibitor. SGTC_3333 9141820 12.094 µM -0.513457880211836 0.286290923602947 no 2432 0.303815533371702 746 1939433 SGTC_26 0302-0163 425.158 µM -0.513523517580014 0.286266137887986 no 2433 0.303792582170195 792 3100915 SGTC_3276 9139060 49.47 µM -0.515097310993791 0.28567215376806 no 2434 0.303242510840075 777 4870619 SGTC_2885 9057732 51.95 µM -0.515854711548023 0.285386503366003 no 2435 0.30297794346703 777 6471414 SGTC_1349 flufenamic acid 69 µM -0.516560594439105 0.28512040515786 no 2436 0.302731464755167 765 3371 A non-steroidal anti-inflammatory. SGTC_789 1309-1135 70.6 µM -0.516781708964065 0.285037075467159 no 2437 0.302654274925709 745 3092424 SGTC_590 k048-0076 22.4 µM -0.516929818381231 0.284981265131693 no 2438 0.302602575698609 774 6832814 SGTC_3036 9090181 49.47 µM -0.519198486232891 0.284127041562136 no 2439 0.301811167280665 761 25236586 SGTC_656 4090-1979 187 µM -0.520262530313742 0.283726818378076 no 2440 0.301440303943925 770 22330961 SGTC_174 3553-0389 74.3 µM -0.520695632474602 0.283563991264012 no 2441 0.301289408697844 745 738071 SGTC_1267 0828-0272 9.49 µM -0.520706168873454 0.283560030605469 no 2442 0.301285738180665 763 745334 SGTC_2627 acetyl isogambogic acid 100 µM -0.520922240578457 0.283478814560039 no 2443 0.301210470708294 772 6857789 A caspase activator and apoptosis inducer. SGTC_1328 1441-0025 69.2 µM -0.521451454182286 0.283279943275195 no 2444 0.301026157647045 769 4562601 SGTC_890 0929-0006 47.2 µM -0.522694993742776 0.282812901518018 no 2445 0.300593261319559 765 1378169 SGTC_1002 4049-0206 172 µM -0.523389948165706 0.282552055562947 no 2446 0.300351458885664 769 4662749 SGTC_158 k038-0087 26.446 µM -0.52367649451617 0.282444536217038 no 2447 0.300251783550864 724 X158 SGTC_3051 9093778 49.47 µM -0.524039151805606 0.282308486363584 no 2448 0.300125654419347 788 17217378 SGTC_3216 9129716 49.47 µM -0.524154147042936 0.282265352811737 no 2449 0.300085665054881 746 8056934 SGTC_2973 9094665 17.96 µM -0.52556929276546 0.281734805762711 no 2450 0.299593748409236 790 25237061 YIL048W NEO1 SGTC_754 3474-0146 171 µM -0.526842492729068 0.281257886256074 no 2451 0.299151485835466 756 24762078 SGTC_735 3076-0345 636 µM -0.527328685224382 0.281075869541899 no 2452 0.298982678763468 762 2888990 SGTC_1571 st070080 73.4 µM -0.527576198852659 0.280983229306606 no 2453 0.298896758124296 758 4315245 SGTC_3285 9112818 20.8695 µM -0.528784847142888 0.280531064418637 no 2454 0.298477355242739 781 17017947 YPR165W RHO1 SGTC_2511 berberine 10.47 µM -0.529140015332101 0.280398260165135 no 2455 0.298354162236014 792 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2749 bexarotene 57.39 µM -0.530047443218377 0.280059093634455 no 2456 0.298039518569253 768 82146 An retinoic acid receptor inhibitor. SGTC_837 0091-0265 12.5 µM -0.530598124034349 0.279853364359471 no 2457 0.297848647973317 772 759367 SGTC_2674 ligustilide 100 µM -0.532593237077752 0.279108622994536 no 2458 0.297157592323928 743 5319022 A signalling regulator. SGTC_342 k048-0088 23.3 µM -0.532929353333261 0.278983251489546 no 2459 0.297041242513171 745 6820570 SGTC_818 4072-2707 53.5 µM -0.533441546140257 0.278792256047242 no 2460 0.296863982221388 763 882871 SGTC_2462 5162487 171.77 µM -0.535109310640549 0.278170792100346 no 2461 0.296287136036664 771 2259986 SGTC_796 1234-0020 70.7 µM -0.536657213488775 0.277594597723969 no 2462 0.295752207986067 743 46495034 SGTC_2775 cyproheptadine 69.59 µM -0.53770163126616 0.277206151364558 no 2463 0.295391526439388 785 2913 A selective serotonin reuptake inhibitor. SGTC_641 4092-0595 30 µM -0.540517411593985 0.276160215573677 no 2464 0.294420128314051 770 786260 SGTC_77 0828-0286 12.516 µM -0.544175071769281 0.27480445820862 no 2465 0.293160502130783 766 745345 SGTC_178 4092-0806 87.505 µM -0.544381919986112 0.274727885468693 no 2466 0.293089342391621 762 2169044 SGTC_1796 st049173 110.4 µM -0.544770905102768 0.274583916324034 no 2467 0.292955545781738 807 94134 SGTC_2232 chlorophetanol 41.5365 µM -0.545599669617172 0.274277302494482 no 2468 0.292670575755723 776 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_799 1310-0557 151 µM -0.547019689000914 0.273752338393784 no 2469 0.292182602755933 797 5354492 SGTC_1672 st016598 6.51 µM -0.54818308694009 0.273322614839174 no 2470 0.291783097050174 787 4665860 YNL267W PIK1 SGTC_1092 toremifene 6.32 µM -0.548205753808174 0.273314245711686 no 2471 0.291775315876318 804 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1675 st018485 24.5 µM -0.549270657914139 0.272921201806501 no 2472 0.291409860326442 795 3323024 SGTC_1345 1488-0192 31.4 µM -0.549751073256842 0.272743977799545 no 2473 0.291245060528494 791 658348 SGTC_2822 7994718 71.43 µM -0.55214817316105 0.271860547855497 no 2474 0.290423419603418 812 1018011 SGTC_2718 lomofungin 53.02 µM -0.552813602629903 0.271615562420587 no 2475 0.290195526531015 790 5351222 A RNA synthesis inhibitor. SGTC_2656 pseudo-anisatin 100 µM -0.553341930967313 0.271421130643929 no 2476 0.290014646881147 802 6708809 A neurotoxin. SGTC_2092 5303694 80.6725 µM -0.554346084278369 0.271051780264099 no 2477 0.289671008518121 785 1963699 SGTC_2119 5528445 120.635 µM -0.555962558287723 0.270457731530715 no 2478 0.289118225390705 773 791935 SGTC_1258 0671-0043 57.1 µM -0.556001928810056 0.270443271116699 no 2479 0.289104768104141 803 4298767 SGTC_1142 3253-1408 9.78 µM -0.558728512014946 0.269442764235275 no 2480 0.288173508772863 791 256655 SGTC_1388 3346-4487 254 µM -0.559619799012545 0.269116113515888 no 2481 0.287869398596241 799 3345614 SGTC_1724 st037281 8.293 µM -0.560304134672303 0.268865444002956 no 2482 0.287636003833844 774 574124 YDL195W SEC31 SGTC_774 k060-0086 136 µM -0.560319719442016 0.268859736727699 no 2483 0.287630689642385 800 5911235 SGTC_294 k038-0071 157 µM -0.560986272665645 0.268615696225273 no 2484 0.28740344763647 776 24152826 SGTC_1945 st075991 56.6 µM -0.563535982162376 0.267683217325004 no 2485 0.286534982708411 770 1084980 SGTC_3110 9122132 49.47 µM -0.564787854604305 0.267225980838311 no 2486 0.286109034505175 759 918317 SGTC_2931 9014674 55.67 µM -0.565218167580589 0.267068903514832 no 2487 0.285962690499126 780 2996810 SGTC_971 1315-0384 26.7 µM -0.566023079410026 0.266775211431973 no 2488 0.285689045717922 801 6769120 SGTC_943 3253-1379 105 µM -0.567942402200032 0.266075558070493 no 2489 0.28503703934407 801 668464 SGTC_2924 9010168 62.78 µM -0.567944510157515 0.266074790165051 no 2490 0.285036323647478 774 2993929 SGTC_2110 5483698 200 µM -0.568004391417607 0.266052976557519 no 2491 0.285015993038512 779 2848765 YHR062C RPP1 SGTC_1511 0906-3109 28.5 µM -0.569028158980078 0.265680177619808 no 2492 0.284668515213617 760 2882180 SGTC_1739 st037196 92.5 µM -0.569631754865204 0.265460505911503 no 2493 0.284463743029078 785 612214 SGTC_1129 3453-1384 223 µM -0.571968383782118 0.264610986775302 no 2494 0.283671697014219 831 1084452 SGTC_1649 st011737 51.3 µM -0.572614708217373 0.264376249502628 no 2495 0.283452799368866 769 1761035 SGTC_1628 st004252 77.7 µM -0.572675879195468 0.264354038430239 no 2496 0.283432086130853 761 692968 SGTC_264 promethazine 12.5 mM -0.573218710013582 0.264156979160939 no 2497 0.283248308801191 815 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1738 st035555 74 µM -0.573757849754431 0.263961333922604 no 2498 0.283065837692518 804 5331140 SGTC_3321 9137793 26.8275 µM -0.573867955171896 0.263921387500893 no 2499 0.283028579602966 775 4904192 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.574334673311334 0.263752095634133 no 2500 0.282870675039655 773 688664 SGTC_2203 7227154 166.4 µM -0.575402206559487 0.263365079456771 no 2501 0.282509656084679 774 896304 SGTC_1802 st050112 57.9 µM -0.576570280006744 0.262941946576792 no 2502 0.282114890395509 786 4662563 SGTC_499 genistein 192 µM -0.577247040641195 0.262696950146911 no 2503 0.281886291871369 806 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2779 methotrexate 400 µM -0.577589672171328 0.262572957481378 no 2504 0.281770590660708 780 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_701 4424-0219 185 µM -0.577617363932161 0.26256293760097 no 2505 0.281761240593972 798 2911779 SGTC_1665 st014639 11.4 µM -0.577760130992333 0.262511282421526 no 2506 0.281713037959628 795 981133 YIL048W NEO1 SGTC_3066 9117245 49.47 µM -0.578189718940573 0.26235588269396 no 2507 0.281568019586723 792 17176980 SGTC_3186 9110464 49.47 µM -0.578286307990342 0.262320948928139 no 2508 0.281535418447124 780 17018021 SGTC_1956 st077085 54 µM -0.579223875377347 0.261981978850645 no 2509 0.281219061438785 810 24208685 SGTC_3135 9127742 49.47 µM -0.579502288915828 0.261881363897547 no 2510 0.281125151311609 784 3643468 SGTC_1241 0364-0022 50.8 µM -0.581656685433587 0.261103464152144 no 2511 0.280398976340167 798 4563895 SGTC_1530 rhein 70.4 µM -0.58293887121972 0.26064106274457 no 2512 0.279967225951966 797 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1065 prochlorperazine maleate 2.48 µM -0.583304925627168 0.260509128003654 no 2513 0.279844023634012 823 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1781 st038725 66.3 µM -0.583505461984057 0.260436864499266 no 2514 0.279776540600086 771 4270275 YIL048W NEO1 SGTC_154 3389-1638 511.116 µM -0.585004747939557 0.259896922412011 no 2515 0.279272262130074 830 5238686 SGTC_615 k087-0205 167 µM -0.585072930500009 0.259872381368169 no 2516 0.279249339719372 799 9642773 SGTC_644 1498-1197 63.3 µM -0.586155067323336 0.259483046467292 no 2517 0.278885656772725 788 6741615 SGTC_1301 naphtanilide LB 4.81 µM -0.586372387921176 0.259404894456555 no 2518 0.278812647784569 805 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_370 0180-0345 38.7 µM -0.588598442030878 0.258605070047963 no 2519 0.278065339636096 770 3989527 SGTC_529 4076-0302 30.3 µM -0.588691307522814 0.25857173111233 no 2520 0.278034185027113 790 5816522 SGTC_1285 0929-0069 65.5 µM -0.589006948468755 0.258458431892032 no 2521 0.27792830621725 784 1206237 SGTC_599 1935-0052 86.5 µM -0.589342504772927 0.258338012267592 no 2522 0.277815768571057 784 9557311 SGTC_125 0133-0007 11.75 µM -0.590202982442568 0.25802934932593 no 2523 0.277527286434123 802 26541 SGTC_2537 larixol 68.93 µM -0.5907426357603 0.257835867301231 no 2524 0.277346437996563 787 6708759 SGTC_2436 5633522 8.09 µM -0.593811284091518 0.256737097109998 no 2525 0.276319170465039 801 5724242 SGTC_1093 fluphenazine 7.97 µM -0.593900233933823 0.256705283833415 no 2526 0.276289421278852 798 6602611 An atypical antipsychotic. SGTC_1623 st003709 20.3 µM -0.59513583572088 0.256263578142144 no 2527 0.275876338095089 783 16192618 SGTC_2153 5569715 200 µM -0.596085398405677 0.255924395789117 no 2528 0.275559089085162 787 2054701 SGTC_2652 actinonin 100 µM -0.600335620974223 0.254409098457274 no 2529 0.274141291846029 799 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_942 3253-1115 227 µM -0.600816360602026 0.25423800074336 no 2530 0.2739811529547 832 46497897 SGTC_1306 1185-0270 9.02 µM -0.601192447031954 0.254104191717093 no 2531 0.273855907268215 805 1548076 SGTC_1863 st057641 20.1 µM -0.602646614755393 0.253587156367006 no 2532 0.273371901485532 813 3921635 SGTC_139 0099-0334 718.624 µM -0.60367339728774 0.253222412739851 no 2533 0.273030402100054 810 97690 SGTC_1847 st056231 15 µM -0.603769645500493 0.253188236665755 no 2534 0.272998401583882 785 5393180 SGTC_2088 5278280 127.392 µM -0.603991035692477 0.25310963404931 no 2535 0.272924801037312 801 791502 SGTC_1303 1160-0052 261 µM -0.605121654674219 0.252708418093543 no 2536 0.272549083444238 795 3562476 SGTC_194 1486-1323 56.904 µM -0.60522457178118 0.252671913157141 no 2537 0.272514895670215 805 5178754 SGTC_1570 verbenone 133 µM -0.606445404551297 0.252239092905256 no 2538 0.272109512826239 806 29025 A natural terpanoid with antifungal properties. SGTC_2187 6125751 200 µM -0.609186384058341 0.251268763069013 no 2539 0.271200452180859 800 874498 SGTC_780 0109-0199 192 µM -0.610891300280502 0.250666205492987 no 2540 0.270635772322476 811 610414 SGTC_143 4032-1194 15.74 µM -0.611276210085263 0.250530275268907 no 2541 0.270508368873029 800 1806963 SGTC_3102 9121669 49.47 µM -0.61213349816045 0.250227665905122 no 2542 0.270224718034718 810 41905072 SGTC_3204 9114183 49.47 µM -0.612861314294794 0.249970910335386 no 2543 0.269984022361146 782 17027248 SGTC_1829 berberine 14.4 µM -0.612943392024191 0.249941964112956 no 2544 0.26995688521388 804 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1090 efavirenz 20.7 µM -0.613666213601563 0.249687124610195 no 2545 0.269717959550088 788 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_871 0574-0004 149 µM -0.614927777985073 0.249242675621639 no 2546 0.269301208588063 813 9551173 SGTC_1331 1472-0049 76.2 µM -0.61595110981396 0.248882465193846 no 2547 0.268963393838538 814 24051409 SGTC_1943 st076331 65.2 µM -0.617765248800894 0.248244574141185 no 2548 0.268365046976927 807 24208415 SGTC_2456 5770359 74.46 µM -0.618069439262034 0.248137699513295 no 2549 0.268264783191771 827 3118787 SGTC_2179 6298986 200 µM -0.618090049623925 0.2481304591328 no 2550 0.268257990521461 793 738374 SGTC_3281 9140613 49.47 µM -0.618179193282885 0.248099144434627 no 2551 0.268228611952093 782 16013766 SGTC_2335 9018011 154.17 µM -0.618642662691327 0.247936369248694 no 2552 0.268075895063647 783 6458208 SGTC_2556 citropten 84.59 µM -0.618971877792486 0.24782078017573 no 2553 0.267967442639988 776 2775 A potential DNA crosslinker. SGTC_1969 st069479 40.1 µM -0.619269056817748 0.247716463839992 no 2554 0.267869562749095 813 3895485 SGTC_1630 st005209 31.3 µM -0.620128420231262 0.247414940480946 no 2555 0.267586621271619 805 3367314 SGTC_1972 st070201 17.4 µM -0.620230478387823 0.247379144546813 no 2556 0.267553029101588 795 2829099 SGTC_68 0986-0284 82.829 µM -0.621033466049886 0.247097600807385 no 2557 0.267288802050154 791 423278 YIL048W NEO1 SGTC_1062 mesoridazine 14.2 µM -0.622493800228806 0.24658601768172 no 2558 0.266808609589745 801 4078 A neuroleptic. SGTC_542 3381-0244 89.3 µM -0.625270622745891 0.245614810600967 no 2559 0.265896728737401 836 1112843 SGTC_1049 3226-0134 66 µM -0.625432241278351 0.245558347075881 no 2560 0.265843703494572 805 5702385 SGTC_2314 7727897 200 µM -0.625645712294308 0.245483778903239 no 2561 0.265773674243536 791 900724 SGTC_2452 5863136 48.41 µM -0.627880296305133 0.244703940713811 no 2562 0.265041179786626 802 2184096 SGTC_431 k089-0097 107 µM -0.628763901625433 0.244395943367129 no 2563 0.264751818044057 812 5499420 SGTC_1824 st053723 68.6 µM -0.629291261165237 0.24421222181787 no 2564 0.264579195710467 810 675225 SGTC_1965 Pectolinarigenin 58.4 µM -0.629305861523859 0.244207136403541 no 2565 0.264574417341735 811 5320438 An anti-inflammatory. SGTC_2145 5634607 200 µM -0.631654385394522 0.243389871653012 no 2566 0.263806370283568 817 308662 SGTC_2428 5615643 7.78 µM -0.632131015279886 0.243224189415569 no 2567 0.263650635020074 826 2253075 SGTC_680 0417-1641 114 µM -0.632295943082959 0.243166872744637 no 2568 0.263596757013923 792 2835990 SGTC_3144 9087057 49.47 µM -0.632365128559193 0.243142831179329 no 2569 0.263574157430511 828 17249618 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.633419187391698 0.242776710642173 no 2570 0.263229969181535 799 6708784 An antioxidant flavonoid SGTC_1947 st076332 61.6 µM -0.633564901026544 0.242726121436937 no 2571 0.263182406489569 824 24208416 SGTC_786 4544-0069 423 µM -0.634337708178736 0.242457911829704 no 2572 0.262930226302168 803 748821 YLR208W SEC13 SGTC_2163 5671233 125 µM -0.634609589966486 0.242363591023185 no 2573 0.262841536010922 797 701023 SGTC_728 3030-5151 22.5 µM -0.636099595609177 0.241847033808146 no 2574 0.262355754542989 812 3125388 SGTC_229 benomyl 22.8748 µM -0.636762202968479 0.241617512212094 no 2575 0.262139874713559 803 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_429 1112-0049 25.5 µM -0.637112264092114 0.241496301754481 no 2576 0.262025860317433 790 2836170 SGTC_2079 5212404 121 µM -0.640113192528486 0.240458571202767 no 2577 0.261049506406081 798 758462 SGTC_1028 k015-0029 4.8 µM -0.640882734308296 0.24019285298752 no 2578 0.260799437156401 821 4588309 SGTC_1470 k295-0292 231 µM -0.641188715408495 0.240087244009198 no 2579 0.260700040209271 818 5045612 SGTC_2811 7967822 32.47 µM -0.642066976707664 0.239784253920893 no 2580 0.260414848260484 801 2232244 SGTC_454 lyso-paf C-16 6.67 µM -0.643756260074847 0.239202057511139 no 2581 0.25986675064726 828 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_726 3448-4391 34.2 µM -0.646459423697889 0.238272045474993 no 2582 0.258990933525946 827 1356692 SGTC_2970 9090938 41.86 µM -0.646863076090924 0.238133340739999 no 2583 0.258860282457337 799 17217104 SGTC_1415 3966-0071 78.1 µM -0.647196883142615 0.238018669987913 no 2584 0.258752264152355 818 2893185 SGTC_596 1155-0152 116 µM -0.648677505694858 0.237510405586782 no 2585 0.25827342342491 823 280313 SGTC_3239 9133757 49.47 µM -0.648725367504871 0.237493985650299 no 2586 0.258257952343119 842 17036923 SGTC_476 mead acid 10 µM -0.650203648693227 0.236987139129435 no 2587 0.257780342260366 824 5312531 An omega 9 fatty acid. SGTC_1230 0170-0365 3.77 µM -0.651948372594094 0.23638970522594 no 2588 0.257217239008586 812 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1461 k072-0203 53.8 µM -0.652144139108998 0.236322722006376 no 2589 0.257154096008007 819 5418714 SGTC_224 benfluorex 43.875 µM -0.653415960600512 0.235887811779658 no 2590 0.256744076012284 834 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1163 k060-0048 49.9 µM -0.653771907201479 0.235766171860922 no 2591 0.256629384081519 816 6809982 SGTC_859 0439-0102 54.6 µM -0.654896673924029 0.235382025521145 no 2592 0.256267140924737 825 610143 SGTC_2171 5739187 198.077 µM -0.655032941339243 0.235335509007874 no 2593 0.256223272655593 803 2262761 SGTC_492 tmb-8 126 µM -0.656966050220432 0.234676166045399 no 2594 0.255601373149416 805 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1244 0416-0015 52.5 µM -0.659032494296344 0.233972476286151 no 2595 0.254937451319763 807 96201 SGTC_835 0312-0010 67.2 µM -0.659046920663803 0.233967567762568 no 2596 0.254932819488067 827 1626196 SGTC_1402 3909-7673 35.9 µM -0.659820050854299 0.233704596249356 no 2597 0.254684657267273 807 5328014 SGTC_115 0527-0192 112.043 µM -0.660313059890883 0.233536990379832 no 2598 0.254526475462288 843 4233931 SGTC_1952 st077036 64.1 µM -0.660458783491509 0.233487462207732 no 2599 0.254479729944986 821 2937007 SGTC_536 3852-0578 10.6 µM -0.660585697259268 0.233444331821519 no 2600 0.254439021949876 823 2869208 SGTC_1506 4226-2149 212 µM -0.660687393819987 0.233409774443055 no 2601 0.25440640491714 829 991114 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.661314000774602 0.233196910561169 no 2602 0.254205482273977 821 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2283 7944793 200 µM -0.662415075471551 0.232823126995115 no 2603 0.253852622377591 812 2970533 SGTC_970 1315-0089 19.5 µM -0.663828341393005 0.232343851604208 no 2604 0.253400092050809 810 6811083 YLR033W RSC58 SGTC_1424 4048-1941 275 µM -0.663938180328931 0.232306625351762 no 2605 0.253364939188423 819 X1424 SGTC_755 1995-0008 37.3 µM -0.672606241658919 0.229379359809432 no 2606 0.250598914885896 796 689533 SGTC_2383 9036125 200 µM -0.673655700548053 0.229026358690329 no 2607 0.250265115972422 825 79580 SGTC_981 1488-1094 54.9 µM -0.673863268894799 0.228956576106415 no 2608 0.250199123135045 825 3449522 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.674702862328935 0.228674434220256 no 2609 0.249932282824353 833 390807 SGTC_956 1185-0240 191 µM -0.674945134641705 0.228593055926962 no 2610 0.249855311718413 827 1416193 SGTC_2729 fluphenazine 10.66 µM -0.675458129476865 0.228420796724178 no 2611 0.249692372275474 831 3372 An atypical antipsychotic. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.675938215353168 0.228259654154005 no 2612 0.249539936639413 831 75037 A free radical scavenger. SGTC_2198 6589944 200 µM -0.676202229550314 0.228171064069188 no 2613 0.249456128605653 813 5290268 SGTC_255 tunicamycin 200.472 nM -0.676444117094541 0.228089915564826 no 2614 0.249379357535923 818 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2098 5376439 882.5 nM -0.676637373976792 0.228025093354283 no 2615 0.24931803005309 818 2844116 SGTC_992 3909-8734 162 µM -0.677269614572992 0.227813099669132 no 2616 0.249117453004944 831 4288319 SGTC_693 4161-2696 114 µM -0.67750878892334 0.227732932142506 no 2617 0.249041597810579 843 805759 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.678723636861195 0.227325979239773 no 2618 0.248656493271156 859 6708760 SGTC_2289 7946404 165.07 µM -0.678830237202523 0.227290289546815 no 2619 0.248622716304338 820 1246120 YPR165W RHO1 SGTC_3320 9137005 35.139 µM -0.679446910924934 0.227083889745045 no 2620 0.248427367455639 818 4908713 SGTC_1027 k015-0025 8.67 µM -0.679687786357546 0.22700329779418 no 2621 0.248351085570216 826 3598955 SGTC_2312 7706453 155.7 µM -0.680401745411498 0.226764516597773 no 2622 0.248125058080709 824 976098 SGTC_1950 st077106 7.18 µM -0.680908312378022 0.226595182968577 no 2623 0.247964754025633 810 13831864 SGTC_1189 1431-2119 7.28 µM -0.682935753848187 0.225918171118696 no 2624 0.247323720047749 842 3107275 SGTC_580 1123-0028 41 µM -0.683230469637872 0.225819853673066 no 2625 0.247230610972015 845 1677248 YPR107C YTH1 SGTC_2544 sphondin 68.51 µM -0.684246248244906 0.225481174539147 no 2626 0.246909841384307 814 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_626 0214-0009 33 µM -0.684796284703507 0.225297902404812 no 2627 0.246736240075335 839 3437874 SGTC_311 1315-0136 58 µM -0.685666510035317 0.225008115732546 no 2628 0.246461715002641 828 6759207 SGTC_702 1488-0190 94 µM -0.686116437631813 0.224858371875118 no 2629 0.246319843096859 813 949357 SGTC_1505 k297-0037 20.6 µM -0.686217005271346 0.224824908914056 no 2630 0.246288137931488 826 4089396 SGTC_2266 7929956 200 µM -0.688362800895109 0.224111588230717 no 2631 0.245612171550267 833 2967153 SGTC_2174 5790901 200 µM -0.688809782379219 0.223963161395978 no 2632 0.245471489399889 842 786020 SGTC_1990 st072050 59.8 µM -0.689191449604146 0.223836467350014 no 2633 0.245351398419047 829 17233948 SGTC_3256 9138902 49.47 µM -0.690081920310013 0.223541034949227 no 2634 0.245071336063498 860 17228773 SGTC_259 usnic acid 108.925 µM -0.693829907037146 0.222299995533042 no 2635 0.243894442385024 861 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1926 methyl fluorone black 53.6 µM -0.694091423398356 0.222213548768348 no 2636 0.243812438419086 800 72721 Reacts with homocysteine. SGTC_1080 nisoldipine 24.4 µM -0.694592336945441 0.222048020520378 no 2637 0.243655407980392 839 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_667 1498-1044 59 µM -0.695097921706848 0.221881020058497 no 2638 0.243496968564335 853 6739982 SGTC_3035 9091303 49.47 µM -0.696178935739196 0.221524189447813 no 2639 0.243158388758291 838 25237002 SGTC_520 3584-0023 682 µM -0.697454693565792 0.221103498388598 no 2640 0.242759141767409 815 1340790 SGTC_2888 9058547 12.99 µM -0.698993297076022 0.220596740576207 no 2641 0.242278109902612 824 16476514 SGTC_1170 0310-0127 64.8 µM -0.699481208955645 0.220436179925079 no 2642 0.242125676178022 857 774975 SGTC_1831 st055328 12 µM -0.700133356296668 0.220221677763841 no 2643 0.241922013138545 833 1103068 SGTC_92 0063-0024 660.874 µM -0.702360972313752 0.219489880966402 no 2644 0.241227038877117 844 3594437 SGTC_3232 9132874 49.47 µM -0.702802903511649 0.219344867857865 no 2645 0.241089293762472 822 3784940 SGTC_319 1348-1596 45.5 µM -0.703149140848612 0.219231293732707 no 2646 0.240981405260438 845 5380505 SGTC_3201 9113999 49.47 µM -0.703669381741026 0.219060705851642 no 2647 0.240819346153617 842 16649224 SGTC_3079 9117512 49.47 µM -0.7053145661 0.218521749722108 no 2648 0.24030724884208 883 7185044 SGTC_2437 5741531 144.16 µM -0.705430066091107 0.218483941069717 no 2649 0.240271319407391 843 2262990 SGTC_233 rapamycin 362 pM -0.705988363632713 0.218301236795269 no 2650 0.240097686948269 839 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2423 st077119 87.2 µM -0.706869114926071 0.218013187753947 no 2651 0.239823909387558 823 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2610 ononetin 44.17 µM -0.707908418657745 0.217673566268411 no 2652 0.239501065692532 846 259632 SGTC_1075 aripiprazole 15.2 µM -0.708338740103719 0.217533036144759 no 2653 0.239367462462286 834 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2957 9076800 11.52 µM -0.708377689571195 0.217520318997639 no 2654 0.239355371709997 842 16459615 SGTC_844 0330-0132 15.3 µM -0.708547917829459 0.217464743869659 no 2655 0.239302533113063 835 2828079 SGTC_2922 7999257 32.47 µM -0.711990202732296 0.216342686821787 no 2656 0.238235421448163 857 2988377 SGTC_1146 3579-1023 7 µM -0.712923595940272 0.216039013840405 no 2657 0.23794651856447 859 X1146 SGTC_287 k060-0039 29.6 µM -0.713008577600903 0.216011377917835 no 2658 0.237920224673698 840 5861974 SGTC_2227 7312221 64.1025 µM -0.714029271889414 0.215679609549736 no 2659 0.237604539583329 859 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1452 4194-0072 190 µM -0.714759951716692 0.215442289566652 no 2660 0.237378692760082 857 1343545 SGTC_3310 9130229 44.1445 µM -0.71509630236149 0.215333096032593 no 2661 0.237274769311935 848 7761258 SGTC_2405 ticlatone 3.52 µM -0.716194785211571 0.21497670617346 no 2662 0.236935541311259 846 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1182 1222-0449 220 µM -0.717251767673004 0.214634104229043 no 2663 0.236609381098895 845 658318 SGTC_747 3448-8087 38.7 µM -0.720304770149734 0.213646312007143 no 2664 0.235668684199299 862 5168703 SGTC_1487 3970-0795 2.82 µM -0.72114426254219 0.21337516105588 no 2665 0.235410380259462 837 3765103 SGTC_1733 st037357 54.9 µM -0.721357388738898 0.213306354530872 no 2666 0.235344828204961 847 1272339 YGL099W LSG1 SGTC_2790 5423970 71.43 µM -0.721593120816013 0.213230264901515 no 2667 0.235272334909027 854 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1329 1447-1697 50.6 µM -0.721952526807037 0.213114286258432 no 2668 0.235161832634649 839 2840515 SGTC_3053 9095903 49.47 µM -0.722311927024567 0.212998346282626 no 2669 0.235051360803442 884 17174018 SGTC_2365 9042475 200 µM -0.723144810222029 0.21272980554583 no 2670 0.234795460809682 845 6464479 SGTC_2694 st077685 81.9 µM -0.723787484420268 0.212522727751212 no 2671 0.234598107074006 829 2838096 SGTC_1168 k815-0004 80.5 µM -0.724000456362343 0.212454131468262 no 2672 0.234532727449672 855 642433 SGTC_2737 bleomycin 30.5 nM -0.724366530638241 0.212336252577734 no 2673 0.234420370949834 844 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2087 5276107 200 µM -0.72468469774151 0.21223383123876 no 2674 0.234322742444979 838 144405 SGTC_2017 5132927 60.65 µM -0.724780585574358 0.212202969600119 no 2675 0.234293323999755 834 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_479 n-linoleoylglycine 10 µM -0.724911025289186 0.212160991599865 no 2676 0.234253308298426 848 6433346 An anti-infammatory. SGTC_346 4513-0042 7.16 µM -0.725920960825198 0.211836139335732 no 2677 0.233943612956199 838 2827372 SGTC_3143 9086658 49.47 µM -0.725928787352026 0.211833623019912 no 2678 0.233941213848576 849 25236626 SGTC_787 4152-0075 138 µM -0.728181620071794 0.211110039416875 no 2679 0.233251207759437 831 9566539 SGTC_3050 9093513 49.47 µM -0.729451628940868 0.210702766660763 no 2680 0.232862723069006 852 25236664 SGTC_322 k048-0136 19.3 µM -0.729809697142436 0.210588022921438 no 2681 0.23275325811016 852 6823282 SGTC_2900 5328528 85.29 µM -0.729835017604951 0.210579910312125 no 2682 0.2327455184793 840 795359 SGTC_1875 nocodazole 6 µM -0.730448080833449 0.210383542454535 no 2683 0.232558168915841 836 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3228 9131799 49.47 µM -0.730793293058965 0.210273016218592 no 2684 0.232452710412243 850 17015818 SGTC_2196 6573537 42.6665 µM -0.73274623157727 0.209648388331814 no 2685 0.231856610464719 865 2903087 SGTC_1409 3909-8004 61.9 µM -0.733919305690678 0.209273717444965 no 2686 0.231498960056853 836 2119279 SGTC_2077 5212015 200 µM -0.735840337452588 0.208661006516547 no 2687 0.230913934860685 839 780900 SGTC_3338 9144300 39.5675 µM -0.736262610383033 0.208526464938414 no 2688 0.230785447898595 839 4901274 SGTC_574 1315-0397 40 µM -0.736578053596851 0.20842599406481 no 2689 0.230689492576328 858 6794277 SGTC_563 tetrahydrosecaminediol 614 µM -0.737121102975943 0.208253095929406 no 2690 0.230524353490369 865 334274 A psychoactive constituent of the cannabis plant. SGTC_2863 9028737 58.44 µM -0.737208762182005 0.208225194591037 no 2691 0.230497702880476 848 6460917 SGTC_1144 3486-0183 12.5 µM -0.740361426522802 0.207223189572605 no 2692 0.229540358895634 880 6744069 SGTC_279 1273-0055 2.93 µM -0.741442546778816 0.206880236986941 no 2693 0.229212577593398 869 2847562 SGTC_357 1325-0123 420 µM -0.741506591106618 0.206859931413287 no 2694 0.229193168442239 866 1098503 SGTC_3289 9119912 71.43 µM -0.74217020829541 0.206649597723785 no 2695 0.22899210815226 856 17014829 SGTC_2424 5537928 59.2 µM -0.742654644100003 0.206496135637313 no 2696 0.228845398088843 854 5382802 SGTC_719 2810-4230 27.3 µM -0.742721521179853 0.206474955273884 no 2697 0.2288251486926 847 721079 SGTC_2455 5377712 9.75 µM -0.74401315981918 0.206066138272101 no 2698 0.228434256856175 821 2243908 SGTC_1253 0550-0034 176 µM -0.744219650116834 0.20600082648567 no 2699 0.228371800982855 850 5969915 SGTC_1412 3909-8563 178 µM -0.747391141007889 0.204999243953204 no 2700 0.227413745678066 871 23767530 SGTC_324 1315-0088 19.6 µM -0.748238170702238 0.204732235723551 no 2701 0.227158255535955 873 6787421 SGTC_1621 st003705 32.4 µM -0.748403962960167 0.204679997432078 no 2702 0.227108266444879 851 24207032 SGTC_456 gingerol 170 µM -0.749177783506572 0.204436284766372 no 2703 0.22687502887101 872 442793 A herb. SGTC_385 1494-0393 12.4 µM -0.749412663107807 0.204362344262555 no 2704 0.226804260451602 859 3090647 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.751101791137181 0.203831072935533 no 2705 0.226295698938841 875 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2248 tofa 1.1 µM -0.751167271902389 0.203810494250858 no 2706 0.226275997013519 846 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1498 4478-3555 97.6 µM -0.751316716942584 0.203763532695012 no 2707 0.226231035453612 842 3437919 SGTC_3172 9105863 49.47 µM -0.754432073715086 0.202786033680578 no 2708 0.225294909229299 860 2348785 SGTC_1323 1348-1351 11.2 µM -0.75470210532893 0.202701438572062 no 2709 0.225213871506515 833 6989654 SGTC_442 cape 100 µM -0.755669101783224 0.202398672362941 no 2710 0.22492380691403 836 5281787 SGTC_2896 9052656 71.43 µM -0.755913366105773 0.202322236103987 no 2711 0.224850569808465 843 6469436 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.760404039827993 0.200920073435134 no 2712 0.223506554623908 860 2346 DNA damaging agent; causes G2/M arrest. SGTC_1031 k035-0009 16 µM -0.761525534222275 0.20057081133724 no 2713 0.223171616738907 865 5180959 SGTC_1376 2910-0861 41.3 µM -0.761545426488455 0.200564619668033 no 2714 0.22316567843031 864 1112859 SGTC_1960 st011366 51.8 µM -0.76167560195091 0.200524104070824 no 2715 0.223126820218354 864 3972846 SGTC_1194 1488-0194 225 µM -0.76378460257613 0.199868387269605 no 2716 0.22249780700603 859 1391452 SGTC_171 k064-0041 9.68 µM -0.76408984193881 0.199773591167449 no 2717 0.222406852659887 851 53325 SGTC_2710 st078562 53.7235 µM -0.764509076876516 0.199643436331243 no 2718 0.222281964813553 866 17250908 SGTC_95 0471-0001 561.058 µM -0.765757521452746 0.199256149061971 no 2719 0.221910296928431 860 4015405 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.766927256249478 0.198893689700208 no 2720 0.221562383580897 877 442882 SGTC_2508 celastrol 40.54 µM -0.76694200084714 0.198889123409597 no 2721 0.221558000096818 819 122724 Celastrol is a natural product and antioxidant. SGTC_861 0443-0273 110 µM -0.76715192513236 0.198824118297146 no 2722 0.2214955961912 870 6149169 SGTC_2371 9071574 200 µM -0.768406793948913 0.198435803052677 no 2723 0.221122772666017 879 45596039 SGTC_1089 terbinafine 2.25 µM -0.769706053309925 0.19803423382069 no 2724 0.220737139255122 865 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_721 1187-1332 279 µM -0.771531428553638 0.197470884851479 no 2725 0.220196000542525 877 25730 SGTC_1180 1193-0155 285 µM -0.771913374471013 0.197353131061741 no 2726 0.220082867696938 864 2921347 SGTC_3072 9116419 49.47 µM -0.772192665985002 0.197267052475137 no 2727 0.220000162319627 857 17170162 SGTC_298 1391-0729 10 µM -0.77223849170113 0.197252931004156 no 2728 0.219986593853441 861 3237558 SGTC_2865 9030313 51.95 µM -0.774526809614757 0.196548549971692 no 2729 0.219309660172402 865 42562754 SGTC_1702 st027038 51 µM -0.77501249366029 0.196399244911282 no 2730 0.219166138542232 854 5521182 SGTC_2943 9068529 45.32 µM -0.775474238955139 0.196257362670079 no 2731 0.219029740996245 876 3270634 SGTC_3260 9137109 49.47 µM -0.778392245163779 0.195362173818842 no 2732 0.218168904530059 834 17478346 SGTC_1259 0671-0132 43 µM -0.778599016773114 0.195298834472024 no 2733 0.218107979226014 859 X1259 SGTC_347 4534-1311 26.2 µM -0.778749605646538 0.195252713164151 no 2734 0.218063614350872 871 2862016 SGTC_2675 theaflavin digallate 100 µM -0.778984429218847 0.195180806249586 no 2735 0.217994443535775 868 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1315 1237-0019 3.69 µM -0.779066738746235 0.195155605502135 no 2736 0.217970201020978 854 825140 SGTC_2958 9077254 16.72 µM -0.780088984311974 0.194842788907247 no 2737 0.217669249964004 860 16457351 SGTC_3280 9140961 49.47 µM -0.781870876707604 0.194298242964477 no 2738 0.217145231033061 892 4901226 SGTC_589 1227-0070 34.1 µM -0.781896888591804 0.194290300607083 no 2739 0.217137586859115 848 2841384 SGTC_2988 9073640 71.4286 µM -0.78334610961516 0.193848114050919 no 2740 0.216711946529386 861 9102229 SGTC_684 1140-0066 328 µM -0.785054857012312 0.193327529509758 no 2741 0.216210702991906 856 6813534 SGTC_2059 5238311 157 µM -0.78706043810518 0.192717601503216 no 2742 0.215623243549319 876 703021 SGTC_527 4476-4215 268 µM -0.78852929577406 0.192271646116924 no 2743 0.215193584778174 847 4418754 SGTC_2564 betulinic acid 100 µM -0.788786920029435 0.192193494714737 no 2744 0.215118277799482 882 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_692 k241-0027 77.8 µM -0.789867090050563 0.191866032189416 no 2745 0.214802696408681 843 3600480 SGTC_815 1582-0027 36.9 µM -0.790216248027543 0.191760255134739 no 2746 0.214700744316202 887 3128206 SGTC_878 0828-0289 13.7 µM -0.7920919029401 0.191192638742165 no 2747 0.214153545506804 861 745350 YLR208W SEC13 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.792793390215158 0.190980617463513 no 2748 0.213949104073476 856 6708739 YPR165W RHO1 SGTC_2219 9098279 200 µM -0.794650160948438 0.190420113536572 no 2749 0.213408515564235 840 902349 SGTC_165 k038-0023 64.381 µM -0.796032073553136 0.19000361160347 no 2750 0.213006696678053 885 46368543 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.796577307826679 0.189839434737712 no 2751 0.212848280367607 876 688751 SGTC_2031 5180455 200 µM -0.797331196015232 0.189612573303348 no 2752 0.212629353555144 893 29949 SGTC_601 0986-0029 62.9 µM -0.800075637043779 0.188788120606164 no 2753 0.211833487833671 855 24747981 SGTC_1003 4049-0218 100 µM -0.802402108431017 0.188090962443187 no 2754 0.211160196924849 877 295161 SGTC_3219 9131112 49.47 µM -0.803869747782899 0.187651983227715 no 2755 0.210736101587873 855 17612988 YMR079W SEC14 SGTC_1547 harmine 94.2 µM -0.805672661742463 0.187113588633704 no 2756 0.210215808348541 860 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_540 1187-0821 17.3 µM -0.805822923021661 0.187068760081696 no 2757 0.21017247933999 869 847520 SGTC_2138 5575593 77.673 µM -0.806307183856451 0.186924332198476 no 2758 0.21003287466132 870 762213 SGTC_2062 5245942 200 µM -0.806552613224361 0.186851160717147 no 2759 0.209962142096392 879 1376160 SGTC_3083 9117465 49.47 µM -0.806685132151197 0.186811659343213 no 2760 0.209923956058716 872 16420915 SGTC_2353 9059630 146.67 µM -0.807436554845903 0.186587772271594 no 2761 0.209707506790736 871 4779114 SGTC_2118 5526350 200 µM -0.808712604304846 0.186207953013525 no 2762 0.209340238211382 881 743594 SGTC_1475 4092-1048 11.7 µM -0.810021519565997 0.185818849365874 no 2763 0.208963903871554 895 2881759 SGTC_3120 9124077 49.47 µM -0.811624093251663 0.185343136598449 no 2764 0.208503681040341 896 18774327 YGL155W CDC43 SGTC_1387 3342-1166 1.8 µM -0.814056658593555 0.184622493072482 no 2765 0.207806246736996 855 3418228 SGTC_432 NS 1619 61.3 µM -0.815447985661913 0.184211099033716 no 2766 0.207407963237272 871 4552 A K+/calcium channel activator. SGTC_402 epigallocatechin gallate 10 µM -0.818693606210834 0.183253638851191 no 2767 0.20648062272868 867 65064 An antioxidant. SGTC_623 k072-0108 16.9 µM -0.820821118219341 0.18262770851108 no 2768 0.205874083841715 882 5382803 SGTC_275 trichlorophene 5.69 µM -0.82171029506933 0.182366501927631 no 2769 0.205620899227591 861 62616 SGTC_2487 5918373 44.05 µM -0.822214482457748 0.182218494466826 no 2770 0.205477418836205 870 2876279 SGTC_3304 9125678 46.087 µM -0.822745490928419 0.182062694701477 no 2771 0.205326370065094 882 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_613 3914-0030 117 µM -0.824678328397604 0.181496296932902 no 2772 0.20477711927201 852 1145395 SGTC_3161 9100388 49.47 µM -0.825510785673311 0.181252694235093 no 2773 0.2045408309309 885 25236368 SGTC_2482 5981709 142.65 µM -0.825570581558759 0.181235203999041 no 2774 0.204523864451288 900 877755 SGTC_569 4130-2812 160 µM -0.826630173718447 0.180925449701146 no 2775 0.204223354793347 879 743552 SGTC_1053 3366-3204 134 µM -0.827145439158941 0.180774940316301 no 2776 0.204077316053579 899 3632071 YPR165W RHO1 SGTC_900 1112-0045 141 µM -0.831532152589257 0.179496758807748 no 2777 0.202836536201522 861 56211 YIL048W NEO1 SGTC_1220 1838-0075 193 µM -0.831705731325242 0.179446299304916 no 2778 0.20278753240671 866 5529645 SGTC_3350 9150499 3.57 µM -0.833343453191789 0.178970651073742 no 2779 0.202325528067397 886 4910996 YPR165W RHO1 SGTC_2733 amorolfine 100 µM -0.835180181108775 0.178438149723759 no 2780 0.201808133383092 920 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2882 9058044 58.44 µM -0.835915543000256 0.17822523481854 no 2781 0.201601208862385 864 18076804 SGTC_1914 st062367 72.6 µM -0.836938159482633 0.177929415188889 no 2782 0.201313664740586 893 978205 SGTC_1896 st058441 89 µM -0.837032748853819 0.177902068294851 no 2783 0.201287080083293 872 688759 SGTC_18 0111-0177 500 nM -0.837736119910008 0.177698798642786 no 2784 0.201089461330044 894 721752 SGTC_2680 butyl paraben 22.24 µM -0.843700511160389 0.17598102250097 no 2785 0.199418390918772 912 7184 An antifungal and steroid mimetic. SGTC_2715 st079500 56.4 µM -0.844344566331132 0.175796162270994 no 2786 0.199238444554511 874 28246688 SGTC_2356 9061756 188.97 µM -0.844574580900385 0.175730172054063 no 2787 0.199174203137214 875 20104043 SGTC_2158 5657123 3.6195 µM -0.845110922237367 0.175576358939137 no 2788 0.199024455328034 911 2858827 SGTC_1917 st066507 28.5 µM -0.846108394864342 0.175290528568745 no 2789 0.198746139006404 880 3156428 SGTC_1067 clotrimazole 1.36 µM -0.846116383060091 0.175288240706091 no 2790 0.19874391107552 868 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_602 3130-1533 38.1 µM -0.84942215443241 0.174343075381727 no 2791 0.197823214903307 887 720941 SGTC_330 1488-0319 80.1 µM -0.853796360226482 0.173097416896523 no 2792 0.196608915782909 867 6846614 SGTC_42 0133-0086 60.653 µM -0.854566406370778 0.172878716331168 no 2793 0.196395615919942 915 162923 Model of phenazepam hydroxylation. SGTC_3311 9131146 2.8755 µM -0.854637640149952 0.172858494149375 no 2794 0.196375891523055 885 4900406 YPR165W RHO1 SGTC_2254 7938975 95.19 µM -0.854670250251658 0.172849237142656 no 2795 0.196366862294862 894 2969277 SGTC_1897 st060201 15 µM -0.854677703062495 0.17284712156282 no 2796 0.19636479876319 895 611878 SGTC_2588 indole-3-carbinol 100 µM -0.854708453074466 0.172838392935973 no 2797 0.196356284849572 890 3712 Induces cell cycle arrest. SGTC_3074 9116018 49.47 µM -0.856924987743493 0.172209952571937 no 2798 0.195743171040451 930 17027303 SGTC_387 norethindrone acetate 66.7 µM -0.858468958823717 0.171773062701416 no 2799 0.195316781905547 905 541197 SGTC_668 1682-0499 62.6 µM -0.859855203470238 0.171381407578662 no 2800 0.194934432302306 892 682214 SGTC_1478 0453-0656 35.7 µM -0.861242126088095 0.170990132609128 no 2801 0.194552351514934 901 5258496 SGTC_1957 st077035 62.4 µM -0.861263096039855 0.170984221010247 no 2802 0.194546578040922 899 705593 SGTC_3220 9131269 49.47 µM -0.862636437927208 0.170597349522076 no 2803 0.194168694850239 906 17722206 SGTC_528 3492-0019 172 µM -0.863115652404262 0.170462486424561 no 2804 0.194036941424761 886 2869262 SGTC_2070 5230947 200 µM -0.86319368898108 0.170440531420438 no 2805 0.194015491500288 901 2835538 SGTC_2213 7173844 200 µM -0.86644836593012 0.169526465621209 no 2806 0.193122165163477 900 892728 SGTC_2270 7924575 90.91 µM -0.867381259062935 0.169265046560241 no 2807 0.192866573408478 897 1262135 SGTC_2635 hydroquinidine 100 µM -0.86755647901778 0.169215974603997 no 2808 0.192818590138087 890 442912 An experimental heart treatment. SGTC_1655 st012546 55.1 µM -0.868184520442491 0.169040160889604 no 2809 0.192646663478557 899 720985 YLR208W SEC13 SGTC_1919 st067113 52.3 µM -0.868821787206123 0.168861884598258 no 2810 0.192472307171413 914 1268243 SGTC_619 1652-1634 108 µM -0.870846888003286 0.168296161946435 no 2811 0.191918879929576 903 5400454 SGTC_1408 3909-7976 48.8 µM -0.87138002844126 0.168147429288853 no 2812 0.191773343415536 897 24152374 SGTC_1245 0418-0076 17.2 µM -0.872208191858739 0.167916560478395 no 2813 0.191547405675736 909 6790114 SGTC_2571 chrysanthemic acid 100 µM -0.873172638540907 0.167647957007842 no 2814 0.191284493057294 922 2743 An insecticide. SGTC_2185 6113692 200 µM -0.876134634435731 0.16682475668764 no 2815 0.190478423129442 900 874150 SGTC_1417 3966-0327 90.4 µM -0.876342871938634 0.166766981424389 no 2816 0.190421832491777 920 651118 SGTC_1857 st056007 79.3 µM -0.876365846987593 0.166760607813488 no 2817 0.190415589423426 888 619834 SGTC_1314 1222-0010 41.1 µM -0.877477888845901 0.166452299231661 no 2818 0.190113561767184 905 3526027 SGTC_204 PMA1.184 62.41 µM -0.883053501892086 0.164912037978336 no 2819 0.18860368263502 890 2252213 YGL008C PMA1 SGTC_2800 7887935 81.82 µM -0.886276100017673 0.164026019069849 no 2820 0.187734382320229 919 2961002 SGTC_3268 9137683 49.47 µM -0.88645095434905 0.163978033231375 no 2821 0.187687286015102 945 1953228 SGTC_1393 3470-5649 58.2 µM -0.886518753702677 0.163959429286743 no 2822 0.187669026497986 885 4108395 SGTC_2521 angolensin 13.4 µM -0.88748110150957 0.163695511543306 no 2823 0.1874099682444 900 821428 A flavenoid. SGTC_964 1287-0107 19.4 µM -0.891855291249803 0.162499395652019 no 2824 0.186235250558767 900 51516812 YPR165W RHO1 SGTC_2006 4011487 200 µM -0.89273130806847 0.162260535386194 no 2825 0.186000540001429 903 45595294 SGTC_2816 7982706 58.44 µM -0.894864614480713 0.161679811227034 no 2826 0.185429732291807 910 2981853 SGTC_3233 9132340 49.47 µM -0.895179162604718 0.161594300338199 no 2827 0.185345660890157 928 17682950 SGTC_1849 st056239 19.2 µM -0.89627601663598 0.161296347844629 no 2828 0.18505268248928 873 5393181 SGTC_3235 9132602 49.47 µM -0.896500792820932 0.161235333283614 no 2829 0.184992678529649 901 4912240 SGTC_681 1642-0006 26.6 µM -0.896834980237768 0.161144647335849 no 2830 0.184903489612882 935 4446530 SGTC_1074 carmofur 3.8 µM -0.897077216262011 0.161078934360261 no 2831 0.184838857660794 912 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2173 5763948 167 µM -0.898069462958757 0.160809943550309 no 2832 0.184574258978564 890 2867177 SGTC_2008 4012253 172 µM -0.899854722884403 0.160326711634046 no 2833 0.184098783971473 892 603940 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.901531621452212 0.159873676071216 no 2834 0.183652864389998 931 688801 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.902995645954426 0.159478836480782 no 2835 0.183264102888577 876 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.904605674304505 0.15904535806857 no 2836 0.18283716408024 891 5379071 SGTC_903 1134-0042 114 µM -0.904893846920091 0.158967853005453 no 2837 0.182760813543489 893 701009 SGTC_10 0279-0212 42.575 µM -0.905571230991224 0.158785765599025 no 2838 0.182581420905139 905 39851 YBR002C RER2 SGTC_2264 7948757 110.76 µM -0.905619410976732 0.158772819561837 no 2839 0.182568665517778 887 2971411 SGTC_198 3454-2873 16.191 µM -0.905940518055844 0.158686555262529 no 2840 0.182483668392024 897 710957 SGTC_195 4234-0266 16.654 µM -0.906595867705239 0.15851059323361 no 2841 0.182310273890518 898 2303354 SGTC_1714 st033236 13.627 µM -0.910961660246093 0.157341640744478 no 2842 0.181157787545587 918 2916566 SGTC_557 1315-0110 16.2 µM -0.912369705571665 0.156965844531049 no 2843 0.180787065706396 902 6833801 SGTC_1653 st012112 65 µM -0.913147780470006 0.156758435965605 no 2844 0.18058241186138 899 720429 SGTC_738 1315-0003 72.4 µM -0.913302284355567 0.156717271906255 no 2845 0.180541790635619 931 6251474 SGTC_2980 9014342 25.29 µM -0.914578725190148 0.156377465373536 no 2846 0.180206415833617 890 2996599 SGTC_2208 7283366 200 µM -0.914611374129541 0.156368780135419 no 2847 0.180197842713116 881 898663 SGTC_3070 9117005 49.47 µM -0.916412200576 0.155890218134933 no 2848 0.179725369287169 926 8779016 SGTC_2280 7785178 200 µM -0.917238759946026 0.155670887111771 no 2849 0.179508770068053 892 2954328 SGTC_1980 st071811 45.7 µM -0.919633961498558 0.155036460166136 no 2850 0.178882036563987 904 4974850 SGTC_577 r071-0003 38.6 µM -0.919677819726753 0.155024859195781 no 2851 0.178870573381994 938 4568517 YMR134W ERG29 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.920084068082766 0.154917429407793 no 2852 0.178764414625425 911 94937 An inhibitor of serotonin biosynthesis. SGTC_556 4058-0063 51.5 µM -0.924254824086252 0.153817343860173 no 2853 0.177676828768354 927 6615692 SGTC_256 clotrimazole 625 nM -0.925174128249416 0.153575563816822 no 2854 0.177437669417446 869 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1169 aniline yellow 25.8 µM -0.925831895783129 0.153402723311801 no 2855 0.177266674278607 898 6051 A DNA damaging agent. SGTC_1457 k015-0032 57.3 µM -0.925920926546646 0.153379338747593 no 2856 0.177243537583963 911 4302660 SGTC_310 1273-0058 1.06 µM -0.926358335641259 0.153264484435811 no 2857 0.177129894458707 860 2734232 SGTC_3230 9131665 49.47 µM -0.926650804337555 0.153187720184568 no 2858 0.177053933937545 894 15943720 SGTC_2136 5328288 199.296 µM -0.926866549140672 0.153131109984549 no 2859 0.176997913482864 923 262395 SGTC_3331 9141060 1.957 µM -0.927130227501271 0.153061941124397 no 2860 0.176929461775837 902 4906567 YPR165W RHO1 SGTC_1438 4092-1045 4 µM -0.928325048160275 0.152748771937264 no 2861 0.176619492385899 899 1351342 SGTC_2292 7671323 168.05 µM -0.92988041957204 0.152341737516338 no 2862 0.17621650101318 920 937504 SGTC_2104 5389443 200 µM -0.929887995068404 0.15233975680299 no 2863 0.176214539653351 923 2244536 SGTC_2570 licareol 100 µM -0.931733231330931 0.151857804644446 no 2864 0.175737204031669 919 443158 SGTC_475 α-linolenic acid 10 µM -0.935402753024424 0.150902385920377 no 2865 0.174790389334488 899 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1341 1486-1360 280 µM -0.936553278528309 0.150603653879108 no 2866 0.174494197268988 934 3976547 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.939643905640166 0.149803128948911 no 2867 0.173700123604852 938 279621 SGTC_3245 9134821 49.47 µM -0.940051824929859 0.149697683344298 no 2868 0.173595489055534 932 17014901 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.941419686842625 0.149344457679345 no 2869 0.173244914383272 910 5355888 SGTC_2602 kawain 100 µM -0.942818177194867 0.148983898488538 no 2870 0.17288695625101 909 5369129 SGTC_1887 st057648 70.8 µM -0.943150189568498 0.148898384454195 no 2871 0.172802043512838 933 688672 SGTC_2358 9037157 4 µM -0.94342530459144 0.14882754991298 no 2872 0.172731702512036 908 2388925 SGTC_2687 chenodiol 100 µM -0.94343084623877 0.14882612332283 no 2873 0.172730285819423 896 5702181 A cholesterol synthesis inhibitor. SGTC_858 0438-0351 2.77 µM -0.945554759781914 0.148280035661056 no 2874 0.172187864090872 918 2799119 SGTC_1344 1488-0097 29.1 µM -0.945590947536537 0.148270742915928 no 2875 0.17217863160583 917 747966 SGTC_978 1416-0512 87.4 µM -0.947097424713827 0.147884236521555 no 2876 0.171794568450305 931 6814003 SGTC_2595 hexamethylquercetagetin 100 µM -0.950608513451278 0.146986040964401 no 2877 0.170901572641838 941 386331 SGTC_1145 3546-0597 10.2 µM -0.950845235882505 0.146925615308909 no 2878 0.170841472695421 909 875334 SGTC_558 k064-0027 21.3 µM -0.951016001339729 0.146882036145066 no 2879 0.170798126542018 890 5088526 SGTC_645 0845-0943 5.41 µM -0.955393029455016 0.14576798224735 no 2880 0.169689488856355 910 1885106 SGTC_3322 9139058 2.11 µM -0.957570971202789 0.145215767857372 no 2881 0.169139571448791 904 4908926 YPR165W RHO1 SGTC_913 3487-1245 167 µM -0.957897595311932 0.145133074266268 no 2882 0.169057199579697 909 4016153 SGTC_350 k064-0020 19.8 µM -0.957953234763698 0.145118990817067 no 2883 0.169043170343806 894 2790705 SGTC_423 5-fluorouracil 457 µM -0.960429615446518 0.144493101115348 no 2884 0.168419519465143 907 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1625 st003711 30.1 µM -0.960900171794672 0.14437437690108 no 2885 0.168301182207752 923 24207034 YER133W GLC7 SGTC_2030 5175110 200 µM -0.961090467770903 0.14432638274982 no 2886 0.168253341060322 940 2831986 SGTC_1242 0402-0103 60.1 µM -0.961441322812528 0.144237922525571 no 2887 0.168165157676166 914 432868 SGTC_950 1165-0508 94.1 µM -0.961865191373729 0.144131102341786 no 2888 0.16805866285219 923 6148369 SGTC_3301 9125354 19.7965 µM -0.964283392570355 0.143522705736215 no 2889 0.167451932392757 890 41905162 SGTC_205 1486-1330 71.903 µM -0.964964525293477 0.143351652541858 no 2890 0.167281290194588 930 4118834 SGTC_555 4296-0685 37 µM -0.969468932578164 0.142223924600912 no 2891 0.166155636840822 920 2908540 YHR072W ERG7 SGTC_2852 9023854 51.95 µM -0.970432223791464 0.141983535378547 no 2892 0.165915546524464 913 19798528 SGTC_757 1066-0008 322 µM -0.97095693598677 0.141852709294426 no 2893 0.16578486184492 906 6842497 SGTC_1283 0922-0125 16.4 µM -0.972089425555317 0.141570624839098 no 2894 0.165503031165019 903 3360884 SGTC_1735 st034310 56.75 µM -0.97214692713116 0.141556312291303 no 2895 0.165488729628995 888 871153 SGTC_2591 skatole 100 µM -0.974302207753111 0.141020554734529 no 2896 0.164953254395078 929 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1597 7-benzyloxygramine 47.5 µM -0.974583798656031 0.140950658852658 no 2897 0.164883376650985 917 260807 SGTC_1838 st055369 84.5 µM -0.979631540981674 0.139701704938383 no 2898 0.163634014928826 921 676036 SGTC_2313 7726885 200 µM -0.980306552425548 0.139535260200475 no 2899 0.163467410644705 926 726423 SGTC_1103 duloxetine 36.1 µM -0.980799381614194 0.139413823289958 no 2900 0.163345841639394 942 60835 A selective serotonin reuptake inhibitor. SGTC_928 2764-0428 58.7 µM -0.981151586558503 0.139327081339165 no 2901 0.163258997218628 938 662578 SGTC_519 k048-0011 62.8 µM -0.982045553148354 0.139107077830593 no 2902 0.163038703444539 903 6836379 SGTC_3164 9100705 49.47 µM -0.983240472989252 0.138813379726105 no 2903 0.162744549808457 891 17174235 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.984172489098256 0.13858459380602 no 2904 0.162515354997661 931 165506 SGTC_331 k048-0133 24.5 µM -0.986884260000157 0.137920385768516 no 2905 0.161849690664476 921 6813582 SGTC_2824 7998404 51.95 µM -0.989550952030338 0.13726934011375 no 2906 0.161196826895171 939 837851 SGTC_325 2810-4341 181 µM -0.98975957071051 0.137218496663567 no 2907 0.161145825102254 898 774970 SGTC_1485 3909-9022 254 µM -0.990268735184002 0.137094459783395 no 2908 0.161021391961444 949 714516 SGTC_315 k915-0449 187 µM -0.990944507134717 0.136929954211252 no 2909 0.160856339000864 911 20970215 YNL149C PGA2 SGTC_1574 spiramycin 23.7 µM -0.991778231036808 0.136727183789112 no 2910 0.160652859538217 926 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2575 plumbagin 510 nM -0.993709846565183 0.136258183662041 no 2911 0.160182073794311 917 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2261 9010538 184.68 µM -0.994422256183448 0.13608548737102 no 2912 0.160008668627349 930 6457250 SGTC_2457 5731572 11.68 µM -1.0018647193423 0.134290305989276 no 2913 0.158204467128599 928 2865357 SGTC_3217 9129673 49.47 µM -1.00204819109899 0.134246257510725 no 2914 0.158160159191018 942 17248312 SGTC_512 prima-1 270 µM -1.00302539074026 0.134011815522609 no 2915 0.157924305318101 928 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2987 9018338 71.43 µM -1.00377062122402 0.133833214916674 no 2916 0.157744594097522 907 5055682 SGTC_1291 0993-0025 5.79 µM -1.00491399340199 0.133559514569155 no 2917 0.157469132849557 935 4353356 SGTC_2084 5306078 60.6385 µM -1.00500465566156 0.133537828327293 no 2918 0.157447304031772 943 679340 SGTC_496 calpeptin 138 µM -1.00543998447599 0.133433732224921 no 2919 0.157342517300772 920 73364 A calpain inhibitor. SGTC_484 loperamide 105 µM -1.0066003254114 0.133156543474654 no 2920 0.157063439013457 907 3955 An opioid-receptor agonist. SGTC_327 1273-0057 3.96 µM -1.00868175742792 0.132660312878928 no 2921 0.156563641701236 912 3108138 SGTC_879 0831-1030 162 µM -1.00988468078803 0.13237410755301 no 2922 0.156275271473838 936 1549252 SGTC_3163 9099914 49.47 µM -1.01174208635879 0.131933021019103 no 2923 0.155830693454876 954 16268368 SGTC_2841 9004761 38.96 µM -1.01366427138944 0.13147761952409 no 2924 0.155371489039086 920 2991039 SGTC_1044 1222-0021 1.78 µM -1.01873423383951 0.130281660780719 no 2925 0.154164577737738 908 4306703 SGTC_105 0111-0055 734.78 µM -1.02249378581536 0.129399690185878 no 2926 0.153273626154028 947 5179370 SGTC_3140 9094243 49.47 µM -1.0230660029576 0.129265814784385 no 2927 0.153138319914564 946 19291112 SGTC_2726 cimetidine 79.27 µM -1.02514826537969 0.128779461006611 no 2928 0.152646617321051 942 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_638 3970-0837 4.09 µM -1.03118432891334 0.12737679763935 no 2929 0.151227194034539 915 4118451 YLR208W SEC13 SGTC_1612 st002233 45.4 µM -1.0323743114993 0.127101527601962 no 2930 0.150948400597061 916 1035021 SGTC_1948 st076329 66.6 µM -1.03486883756977 0.126525831109786 no 2931 0.150365084783862 930 24208413 SGTC_1235 benzylparaben 21.5 µM -1.03635247221696 0.126184294798806 no 2932 0.150018867364289 958 7180 SGTC_122 0236-0016 402.397 µM -1.0387749697249 0.125628012211857 no 2933 0.149454702476491 933 6808838 SGTC_136 0097-0015 404.482 µM -1.04142085967285 0.125022389219855 no 2934 0.148840132740596 947 4861337 SGTC_1691 st019933 84.6 µM -1.04152891932894 0.124997698649574 no 2935 0.148815069307379 966 6176082 SGTC_295 k015-0027 31 µM -1.04433246975361 0.12435830517871 no 2936 0.148165797667583 943 3887424 SGTC_471 1-acyl-paf 4 µM -1.04456152590997 0.124306166599549 no 2937 0.14811283464944 925 16759367 SGTC_1983 st071813 46.9 µM -1.04554317511058 0.124082893277226 no 2938 0.147885998425227 944 11838595 SGTC_2027 5150920 200 µM -1.05096724089801 0.122854263859968 no 2939 0.146636817874507 914 786715 SGTC_700 3453-2283 142 µM -1.05168316752011 0.1226927356553 no 2940 0.146472468120203 938 565664 SGTC_2009 4012297 12.05 µM -1.0552284991846 0.121895029396755 no 2941 0.145660416491042 942 45595307 SGTC_2850 9015429 58.44 µM -1.05759892209867 0.121363716265621 no 2942 0.145119167079063 951 6457570 SGTC_2731 amoxapine 43.43 µM -1.05901922961019 0.121046145855794 no 2943 0.144795511115291 983 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1921 5740136 50 µM -1.05962927910605 0.120909922869445 no 2944 0.144656643978529 935 1774243 SGTC_2624 nerol 100 µM -1.05963485595831 0.120908678065885 no 2945 0.144655374919234 945 637566 A natural product oil. SGTC_1749 st037932 54.2 µM -1.06032652660477 0.120754360874678 no 2946 0.144498037630917 968 594497 SGTC_2516 gossypol 71.55 µM -1.06242354225665 0.120287347607153 no 2947 0.144021725439802 963 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_609 0986-0026 86.3 µM -1.06532424388246 0.119643449993955 no 2948 0.143364612694845 925 2848610 SGTC_2323 6148992 148.28 µM -1.0656956210339 0.119561187588238 no 2949 0.143280628897924 945 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_723 4182-0001 115 µM -1.07136720073788 0.118309851635685 no 2950 0.14200217730184 949 744821 YLR208W SEC13 SGTC_2836 9010338 19.48 µM -1.07250478927404 0.118059981308071 no 2951 0.141746681988107 948 2994051 SGTC_2560 caryophyllene 100 µM -1.0762212017884 0.117246276891954 no 2952 0.14091416990451 961 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1499 4480-0877 67.3 µM -1.07912596182792 0.116613054651383 no 2953 0.140265789600978 929 2861909 SGTC_329 k048-0121 21.3 µM -1.07929456758294 0.116576374106882 no 2954 0.140228216918805 956 6832902 SGTC_1123 mangostin 811.285 nM -1.08029521637096 0.116358849191594 no 2955 0.140005369609349 900 5281650 An antioxidant. SGTC_1005 4092-0690 4.4 µM -1.08108945439107 0.116186399754319 no 2956 0.139828661954579 964 1529343 SGTC_3355 9151058 44.0485 µM -1.08160004150626 0.116075634025697 no 2957 0.139715143036003 941 17015728 SGTC_1884 5633444 25 µM -1.08758641573875 0.114782550863742 no 2958 0.138388865172781 935 5724239 SGTC_161 4065-0411 162.148 µM -1.09430742592171 0.113343033408663 no 2959 0.136910084762783 954 1906281 YLR208W SEC13 SGTC_2974 9094440 9.66 µM -1.0948345664169 0.113230676592742 no 2960 0.136794559902938 939 25236134 SGTC_3263 9137018 49.47 µM -1.0949590282075 0.113204159912361 no 2961 0.136767293351348 942 43844957 SGTC_2128 5255449 168.493 µM -1.09528292744574 0.113135173697946 no 2962 0.136696352321672 933 736008 SGTC_2864 9034755 47.6 µM -1.09566765653076 0.113053270521172 no 2963 0.136612120917602 940 4930451 SGTC_396 dithiazanine 1.25 µM -1.09976196368065 0.112184273021026 no 2964 0.135717924465951 943 10578 An antihelmenthic. SGTC_1278 0874-0585 172 µM -1.10156977738145 0.111802096296597 no 2965 0.135324376754131 961 766306 SGTC_2826 7992541 19.48 µM -1.1045508966732 0.111173915075258 no 2966 0.134677118996729 994 2985066 SGTC_584 0986-0246 15.4 µM -1.10700817750978 0.110658020377371 no 2967 0.134145196392969 976 53315 YDR232W HEM1 SGTC_579 4491-1009 110 µM -1.10970580377139 0.110093644440865 no 2968 0.133562910571333 986 1271041 SGTC_3062 9077494 49.47 µM -1.11052549616946 0.109922564671362 no 2969 0.133386323824214 851 16459633 SGTC_1216 1165-0504 9.65 µM -1.11061520237633 0.109903853483322 no 2970 0.133367008125328 971 6304004 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.11139955321551 0.109740348604766 no 2971 0.133198202282538 938 804 An inhibitor of viral and cellular DNA polymerases. SGTC_926 2268-1401 59.4 µM -1.11314134342002 0.109377881607773 no 2972 0.132823864916837 959 2931578 SGTC_1368 1852-0141 284 µM -1.11391322622923 0.109217527880606 no 2973 0.132658207367341 974 2838987 SGTC_1971 st069429 63.5 µM -1.11429875385942 0.109137500257214 no 2974 0.132575520709759 938 1246522 YGL099W LSG1 SGTC_2645 abamectin 100 µM -1.11577247569801 0.108831974276098 no 2975 0.132259769175379 902 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1131 3454-3128 32.3 µM -1.11832419150281 0.108304418126486 no 2976 0.131714279258606 931 710982 SGTC_2120 5538279 151.968 µM -1.11931837048893 0.108099374948093 no 2977 0.131502170701649 963 2058197 SGTC_52 0329-0193 875 nM -1.12266403136328 0.107411406420125 no 2978 0.130790104793993 961 3739292 SGTC_3335 9143315 29.6265 µM -1.12395080321154 0.107147649512815 no 2979 0.130516948639595 933 4899691 SGTC_102 gallobenzophenone 83.616 µM -1.12408141072716 0.107120904283297 no 2980 0.130489245323389 932 70837 SGTC_643 k048-0106 28.4 µM -1.12508032136569 0.106916510989454 no 2981 0.130277499684154 969 6763920 SGTC_2425 5628681 7.85 µM -1.12809341918435 0.106301687018037 no 2982 0.129640234044971 958 5714958 SGTC_138 0850-0259 40.9225 µM -1.13319871989466 0.105265783892749 no 2983 0.128565405821439 943 6813004 SGTC_2080 5212524 12.4 µM -1.13340803675046 0.105223468378178 no 2984 0.128521470334412 941 260183 SGTC_2587 piperic acid 92.2 µM -1.13482298650634 0.104937744796114 no 2985 0.128224746518015 954 5370536 SGTC_3206 9114350 49.47 µM -1.13639416756583 0.104621131719875 no 2986 0.127895817834713 947 17087243 SGTC_1467 k284-1082 293 µM -1.14197760114161 0.103501597847595 no 2987 0.126731665121869 963 3334705 SGTC_148 3253-0744 288.01 µM -1.14290934518068 0.103315623631599 no 2988 0.126538116051507 942 6893655 SGTC_1072 oxiconazole 14.9 nM -1.1444916794245 0.103000348988907 no 2989 0.126209893308215 944 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1227 3909-8010 46.6 µM -1.14546314007906 0.102807135370231 no 2990 0.126008677981284 960 15982272 SGTC_269 exalamide 29 µM -1.14603555016858 0.102693412223347 no 2991 0.125890221414973 959 3316 A derivative of salicylamide. SGTC_1842 st055362 61.2 µM -1.14849394614673 0.10220603178014 no 2992 0.125382355370871 948 676032 SGTC_3259 9138485 49.47 µM -1.15025413261868 0.101858107461872 no 2993 0.125019608161253 953 17646153 SGTC_458 nppb 133 µM -1.15045081257445 0.101819284656554 no 2994 0.124979121042041 982 4549 A chloride channel blocker. SGTC_711 k292-0785 179 µM -1.15059002663975 0.101791811597782 no 2995 0.12495046897365 945 4146315 SGTC_3229 9132204 49.47 µM -1.1508800706357 0.10173459049276 no 2996 0.124890788880693 981 17682924 SGTC_1261 0712-0010 12.7 µM -1.15364790853029 0.101189717400458 no 2997 0.12432227418006 966 2840123 SGTC_1962 st076595 64.5 µM -1.15425927416878 0.101069651996448 no 2998 0.124196943932613 959 279619 SGTC_977 1348-1378 135 µM -1.15491471711519 0.100941045671822 no 2999 0.124062676017736 945 X977 SGTC_2561 acetosyringone 100 µM -1.15494995019416 0.100934135869654 no 3000 0.124055461376228 968 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2090 5301565 104.445 µM -1.15595857527537 0.100736473660755 no 3001 0.123849050736562 963 2056344 SGTC_2805 7950783 58.44 µM -1.15896983162912 0.10014803171673 no 3002 0.123234241172487 955 1178958 YDL195W SEC31 SGTC_412 gemfibrozil 100 µM -1.15910409065889 0.100121854169106 no 3003 0.12320687933855 957 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2678 equilin 100 µM -1.16372088006933 0.0992247192889849 no 3004 0.122268572415318 913 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3016 9080866 49.47 µM -1.16570083518577 0.0988417805015664 no 3005 0.121867711192734 970 17066299 SGTC_140 0062-0056 502.533 µM -1.16772732562613 0.0984509623797075 no 3006 0.121458385405557 974 3758964 SGTC_236 1509-0011 5.31 µM -1.16878262555393 0.0982478914610016 no 3007 0.121245611114601 973 3107280 SGTC_420 mitomycin C 81.9 mM -1.17692029904847 0.0966922588977744 no 3008 0.119613659587656 941 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3044 9093193 49.47 µM -1.17802386259021 0.0964826978134089 no 3009 0.119393546589628 953 25236277 SGTC_1773 st048542 73.5835 µM -1.17922726866545 0.0962545577079867 no 3010 0.119153845283732 976 3237138 SGTC_2315 7733312 200 µM -1.18039275841455 0.096033983938245 no 3011 0.118922020390041 953 726316 SGTC_1290 0986-0249 10.2 µM -1.18105133512047 0.0959095100261491 no 3012 0.11879116534315 975 53329 SGTC_576 1073-0113 22.7 µM -1.18367641625596 0.0954145371238493 no 3013 0.118270589027544 989 5439563 SGTC_814 3342-0569 96 µM -1.18398768546151 0.0953559706013249 no 3014 0.11820896878332 956 4346283 SGTC_3030 9087619 49.47 µM -1.18748882732121 0.0946990390927476 no 3015 0.117517430503166 953 25236973 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.18968234511322 0.0942891647514853 no 3016 0.11708563351911 983 6710655 SGTC_925 2064-1272 59.6 µM -1.19576806632793 0.0931588576465513 no 3017 0.115893540438289 977 6815817 SGTC_2928 9011484 9.79 µM -1.19620036463977 0.0930789490050331 no 3018 0.115809189305806 944 2994751 SGTC_824 1304-0008 100 µM -1.19850724476284 0.0926533876284376 no 3019 0.115359802144553 977 768245 SGTC_1157 4092-0394 27.6 µM -1.20046943644267 0.0922925466829958 no 3020 0.114978537885102 981 3659885 SGTC_2589 lobaric acid 100 µM -1.20291048246835 0.0918450990316193 no 3021 0.114505481720255 990 73157 A novel microtubule depolymerizer. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.20314090751329 0.0918029448904486 no 3022 0.114460898762127 978 229346 A bile salt which induces apoptosis. SGTC_187 1488-2104 32.728 µM -1.20326899917241 0.0917795178989854 no 3023 0.114436120754221 981 2852859 SGTC_1804 st050076 49.1 µM -1.20355227720249 0.0917277242262791 no 3024 0.114381337107054 992 3895976 SGTC_3031 9088762 49.47 µM -1.20622689461666 0.0912397725067523 no 3025 0.113865008307653 987 205253 SGTC_351 caspofungin 25 nM -1.20692044557196 0.0911135573032737 no 3026 0.113731391484115 959 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_921 1561-0023 372 µM -1.20914938739348 0.0907088022803693 no 3027 0.113302729104792 955 24050882 SGTC_2260 7964312 200 µM -1.21328582912634 0.0899612017423378 no 3028 0.112510279459302 994 231951 SGTC_3133 9127736 49.47 µM -1.21360868592202 0.0899030433710388 no 3029 0.112448594309788 949 27243420 SGTC_2768 sulfasalazine 50.2 µM -1.21417782511455 0.089800588545136 no 3030 0.112339913190212 996 5384001 An antioxidant and salicylic acid derivative. SGTC_390 dec-rvkr-cmk 16.7 µM -1.21468797245492 0.0897088270507626 no 3031 0.112242560786223 974 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1984 st072354 53.1 µM -1.21707119045017 0.0892810749551336 no 3032 0.111788565437016 962 5762938 SGTC_1523 st012844 44.7 µM -1.21837458024976 0.0890477787581996 no 3033 0.111540830176989 987 4274103 SGTC_3248 9135562 49.47 µM -1.22092232535669 0.0885930638733741 no 3034 0.111057715332044 969 17650701 SGTC_197 4544-0043 41.561 µM -1.2244145313074 0.0879725973689758 no 3035 0.110397945147891 985 896523 SGTC_1709 st033179 39.1045 µM -1.2269695167245 0.0875207052527151 no 3036 0.109917024189187 974 573381 SGTC_3094 9117742 49.47 µM -1.23116195429819 0.0867829590615146 no 3037 0.109131148869712 984 17149698 SGTC_526 4469-0568 170 µM -1.23884457863907 0.0854431181186819 no 3038 0.107701530657397 974 2901964 SGTC_2701 st077767 14.721 µM -1.24057483483033 0.0851435123526923 no 3039 0.107381426568969 979 5721188 SGTC_3318 9139014 38.6185 µM -1.24426492402487 0.0845071789551332 no 3040 0.106701037968972 984 16643984 SGTC_1689 st020265 53.493 µM -1.24619878021002 0.0841751253101918 no 3041 0.106345713388931 989 5758320 YPR016C TIF6 SGTC_1232 0279-0259 161 µM -1.25105373869976 0.083345819351773 no 3042 0.105457435991551 978 1560000 SGTC_469 w7 172 µM -1.25241532995278 0.0831143438348082 no 3043 0.105209281581865 976 45115570 A P450 inhibitor. SGTC_2416 tofa 880 nM -1.25255056910154 0.0830913791025422 no 3044 0.105184656897204 983 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1357 1503-1303 39.5 µM -1.25334981861584 0.0829557573125546 no 3045 0.105039212688452 967 292895 SGTC_2507 purpurin 79.67 µM -1.25485073259236 0.0827015226494284 no 3046 0.104766475871663 982 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2470 5664817 21.68 µM -1.25542245268308 0.0826048353137819 no 3047 0.10466272142047 997 2859561 SGTC_500 h-89 112 µM -1.25609096356588 0.0824918869879782 no 3048 0.104541496011288 990 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1647 st011722 22.4 µM -1.25792891371918 0.0821819551928042 no 3049 0.104208732940373 971 2854783 SGTC_71 0417-1750 47.813 µM -1.25926721814075 0.0819568306180648 no 3050 0.103966914862466 940 6811472 SGTC_1729 st035615 45.989 µM -1.26147882883053 0.0815858206752802 no 3051 0.103568191497505 962 17385451 SGTC_946 3434-1334 87.4 µM -1.2653029813108 0.0809472880683789 no 3052 0.102881369135312 973 4047976 SGTC_908 3448-7491 47.7 µM -1.26555951623994 0.0809045889009461 no 3053 0.102835413881626 932 1203031 SGTC_1497 4476-2978 41.3 µM -1.26709264323835 0.0806497606977343 no 3054 0.102561082890463 962 1528379 SGTC_853 0419-0306 21 µM -1.27014698686548 0.0801438914735995 no 3055 0.10201613859318 990 762713 SGTC_2626 ethyl orsellinate 100 µM -1.27149711427093 0.0799210454159074 no 3056 0.101775926702231 988 75653 A natural product. SGTC_3088 9117578 49.47 µM -1.27389101162428 0.0795270717465137 no 3057 0.101351022161174 1030 678341 SGTC_1676 st018489 23.4 µM -1.27491287387241 0.0793593478655428 no 3058 0.101170040933167 979 3696235 SGTC_144 4161-2749 112.381 µM -1.27815101527671 0.0788296223503632 no 3059 0.100598092038373 976 797501 YMR168C CEP3 SGTC_438 sphingosine 6.67 µM -1.27912016137434 0.0786716023785058 no 3060 0.100427372449416 998 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1391 3442-0225 151 µM -1.28169144657327 0.0782535158985423 no 3061 0.0999754533131236 991 5227075 SGTC_1761 st044296 37 µM -1.28650072853212 0.0774760614355239 no 3062 0.0991341823647186 997 1826700 SGTC_2818 7996756 12.99 µM -1.28932752744754 0.0770218345820109 no 3063 0.0986421224383099 1010 2241621 SGTC_3115 9123671 49.47 µM -1.29305163274387 0.0764265164543815 no 3064 0.0979966009497518 1018 3286988 SGTC_770 0389-1121 67.2 µM -1.29384165197086 0.0763006789405812 no 3065 0.0978600610798577 990 6753108 SGTC_486 niguldipine 82 µM -1.29497463428304 0.076120488135865 no 3066 0.0976644899924402 989 1236 A calcium channel blocker. SGTC_624 k048-0052 28 µM -1.29752033158503 0.0757167993253828 no 3067 0.097226107077961 998 6835531 SGTC_3200 9114385 49.47 µM -1.29932463557638 0.0754316673786824 no 3068 0.096916271648769 975 17018030 YLR208W SEC13 SGTC_1148 3909-7663 27.7 µM -1.30216401407951 0.0749846220542733 no 3069 0.0964301619722812 1010 4084526 SGTC_1389 3405-0187 19 µM -1.3042263851509 0.0746611814978869 no 3070 0.0960782030988901 974 799890 SGTC_768 0384-0033 77.3 µM -1.31328902992998 0.0732524989883914 no 3071 0.0945427868235866 967 3965305 YMR134W ERG29 SGTC_892 0929-0076 29 µM -1.31583158735451 0.0728609636652412 no 3072 0.0941152873855256 983 5751038 SGTC_3291 9121177 71.43 µM -1.31675758512925 0.0727187654359464 no 3073 0.0939599471769596 994 17015612 SGTC_2612 dictamnine 15.46 µM -1.3220421632581 0.0719113179160329 no 3074 0.0930770556158806 960 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1494 4358-1428 177 µM -1.32882196699591 0.0708855001173682 no 3075 0.0919533565385186 988 1564571 SGTC_1496 4469-0713 57.4 µM -1.33024249365284 0.0706719988003651 no 3076 0.0917191937566315 1023 746691 SGTC_296 1222-0039 74.9 µM -1.3315145591259 0.0704812305148053 no 3077 0.0915098788375209 1008 5984176 SGTC_1843 st055809 45.5 µM -1.33921359843311 0.0693350638777833 no 3078 0.0902505733791648 1005 16413835 SGTC_3184 9108758 49.47 µM -1.34696207806371 0.0681960873148922 no 3079 0.0889962231979436 1008 902885 SGTC_1518 st038567 90.8 µM -1.3479389081356 0.0680535305969099 no 3080 0.0888390162948255 1010 77966 SGTC_769 0302-0231 76 µM -1.3487635651175 0.0679333609193263 no 3081 0.0887064605222874 1015 571869 YER009W NTF2 SGTC_1152 3909-8331 15.9 µM -1.35399773753776 0.0671744500642903 no 3082 0.0878685497628788 986 16001939 SGTC_2095 5432005 200 µM -1.35456631760386 0.0670924070531319 no 3083 0.087777885459312 1007 783734 SGTC_2164 5685496 200 µM -1.35507902196301 0.067018493063804 no 3084 0.0876961908005287 1017 759046 SGTC_826 1683-5028 118 µM -1.36019374683779 0.0662845731140344 no 3085 0.0868843104329314 994 722377 SGTC_134 0269-0018 6.916 µM -1.36022426219115 0.0662802131719637 no 3086 0.0868794835198747 1005 4378915 SGTC_1363 1636-0063 10.4 µM -1.36339067421134 0.0658290117484051 no 3087 0.0863797093158053 996 6072185 SGTC_1545 lovastatin 49.4 µM -1.36352337008238 0.0658101552041816 no 3088 0.0863588121452917 1003 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_976 1348-1067 47.6 µM -1.3708344071912 0.0647776869602207 no 3089 0.0852132912260532 1007 5310671 YGL099W LSG1 SGTC_1366 1683-0113 21.9 µM -1.37558857754207 0.0641130786969056 no 3090 0.0844745225271273 1018 708623 SGTC_166 k072-0058 166.424 µM -1.38134870693194 0.0633149587195459 no 3091 0.083585884459674 991 5846229 SGTC_801 0866-0028 10.1 µM -1.38195725457675 0.0632310924920303 no 3092 0.0834924131809808 1006 6849771 SGTC_2334 9017922 200 µM -1.38213355341729 0.0632068122551502 no 3093 0.0834653488345624 996 3163164 SGTC_1681 tripelennamine 100 µM -1.38227566977961 0.0631872449844157 no 3094 0.0834435367784762 984 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1019 4262-0212 3.4 µM -1.38287503826972 0.0631047729129787 no 3095 0.083351592680644 1000 4677213 SGTC_1426 4048-4480 71.7 µM -1.3834930147089 0.0630198282209804 no 3096 0.0832568738535495 1004 14224343 SGTC_3028 9087778 49.47 µM -1.38361799100646 0.0630026602863853 no 3097 0.0832377282587525 988 17217395 SGTC_48 0382-0018 55 µM -1.38429337978282 0.062909945484206 no 3098 0.0831343201578111 1017 762596 SGTC_2939 9044578 71.43 µM -1.39067173548714 0.062039583159117 no 3099 0.0821624961485507 1009 2653634 SGTC_960 1222-0186 7.7 µM -1.39488711806099 0.0614695466688405 no 3100 0.0815249411611949 1010 3126296 SGTC_3171 9103192 49.47 µM -1.39595692574723 0.0613255318837787 no 3101 0.0813637333345682 1025 13018434 SGTC_418 lividomycin a 100 µM -1.40078124408988 0.0606793666916755 no 3102 0.0806397494942304 1012 72394 An antibiotic. SGTC_1317 1273-0028 910 nM -1.4022007676761 0.0604902543673686 no 3103 0.0804276512423448 986 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2789 5281112 71.43 µM -1.40612815854152 0.0599694404703559 no 3104 0.079843036100236 996 765948 SGTC_2140 5586273 200 µM -1.40710731278122 0.059840142657691 no 3105 0.0796977850019452 1011 854421 SGTC_2855 9016525 58.44 µM -1.4176557120919 0.0584610308935918 no 3106 0.0781456530559299 997 43811474 SGTC_1202 1988-0068 29.6 µM -1.41832235446509 0.0583747187506185 no 3107 0.0780483365352197 1000 2850480 SGTC_2155 5570423 76 µM -1.42066101882863 0.0580727162253051 no 3108 0.077707665047286 1020 797402 SGTC_3112 9123419 49.47 µM -1.42402915902368 0.057639931774667 no 3109 0.0772190156885382 1031 17015854 SGTC_2293 7624732 200 µM -1.42829313735251 0.0570956806591373 no 3110 0.0766037511475665 997 894453 SGTC_2661 dactinomycin 12.96 µM -1.4284700436278 0.0570731881710984 no 3111 0.0765783055038445 1009 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1326 1431-2094 10.8 µM -1.43760208083814 0.0559215535467883 no 3112 0.0752734950902352 1009 616278 SGTC_483 fpl-64176 144 µM -1.43779651306776 0.055897234634089 no 3113 0.075245899513331 1030 3423 SGTC_2766 oltipraz 83.91 µM -1.43940470051087 0.0556964078555226 no 3114 0.075017946678867 943 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_203 k066-0004 30.888 µM -1.44186263535978 0.0553905672754684 no 3115 0.0746705644009745 1044 6795412 SGTC_3026 9090633 49.47 µM -1.44404193679594 0.0551205075557257 no 3116 0.0743635895906107 1006 25236842 SGTC_2833 9001315 45.46 µM -1.44580190935755 0.0549031713202369 no 3117 0.0741163852157181 1008 2989378 SGTC_2015 5119600 184 µM -1.44654278475328 0.0548118845828405 no 3118 0.0740125103752558 1017 2828786 SGTC_1185 1319-0113 81.3 µM -1.4478835215511 0.0546469911539878 no 3119 0.0738248144594141 1017 4672763 SGTC_1637 st007924 17.4 µM -1.45093123015789 0.0542736212584956 no 3120 0.0733995053022828 980 683336 SGTC_2214 7179297 48.276 µM -1.45122881370297 0.0542372732000834 no 3121 0.073358078011338 1024 769744 SGTC_1429 4049-0205 9.46 µM -1.45217693800305 0.0541215938981702 no 3122 0.0732262067043073 1006 22774478 SGTC_1519 esterone 74 µM -1.45427740986865 0.0538660138016508 no 3123 0.0729347054356249 1030 698 A steroid. SGTC_234 nsc-17383 10.7 µM -1.4544238860921 0.0538482266511803 no 3124 0.0729144107982545 986 408974 SGTC_302 1094-0063 18.9 µM -1.45479269097608 0.0538034619046092 no 3125 0.0728633311282353 1013 5440289 SGTC_1732 st034308 51.822 µM -1.45663201086597 0.053580649008839 no 3126 0.072608993263956 993 830119 SGTC_1150 3909-7983 10.9 µM -1.4657071817119 0.0524919760824109 no 3127 0.0713640384028501 1018 23965914 SGTC_1342 1486-1464 234 µM -1.47626240777667 0.0512479216678225 no 3128 0.069936730856204 1008 3253938 SGTC_2189 6047310 154.431 µM -1.47713225515976 0.0511464553298115 no 3129 0.0698200944129823 1019 711535 SGTC_1977 st070720 65.3 µM -1.47882085838783 0.0509499388278974 no 3130 0.069594099784718 1009 682188 SGTC_2322 7413319 38.22 µM -1.48256977436041 0.0505157954584586 no 3131 0.069094376328262 982 1840400 SGTC_3023 9089636 49.47 µM -1.48594309230941 0.0501276719860454 no 3132 0.0686470870452651 1053 17249241 SGTC_120 rhodamine 6G 52.259 µM -1.49131690021528 0.049514292489044 no 3133 0.0679391569590641 1028 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2043 5101342 149 µM -1.49324063402855 0.0492961744718418 no 3134 0.0676871045678505 1029 678451 SGTC_1581 himbacine 57.9 µM -1.49981408463907 0.0485566436728616 no 3135 0.0668312839371123 1047 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2344 7990960 76.95 µM -1.50102842883956 0.0484210023718496 no 3136 0.0666741043486443 980 140813 SGTC_1076 itraconazole 331 nM -1.50259220600038 0.0482467762499177 no 3137 0.066472117233163 1025 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1998 st075797 76.8 µM -1.50524994310282 0.0479518189022655 no 3138 0.066129914665352 1011 24208315 SGTC_607 4491-0986 66.8 µM -1.5090774605842 0.0475295766700889 no 3139 0.0656394943912617 970 698981 YDR232W HEM1 SGTC_1695 st026914 34.495 µM -1.51031793362078 0.0473933716181776 no 3140 0.0654811589153325 1036 3289191 SGTC_1171 0368-0077 21.4 µM -1.51752980564544 0.0466076852836246 no 3141 0.0645664870676804 1028 3239779 SGTC_2265 7929201 200 µM -1.52775959831272 0.0455111815341109 no 3142 0.0632861183667586 1019 1265108 SGTC_660 4031-1742 102 µM -1.53657077275895 0.0445834504108424 no 3143 0.0621992271926195 994 6738706 SGTC_63 0099-0242 26.702 µM -1.53830403999793 0.0444027596527055 no 3144 0.0619871462021886 1024 3898502 YLR359W ADE13 SGTC_2971 9092186 9.93 µM -1.5391769303114 0.0443119856981326 no 3145 0.0618805540089791 1017 25236400 SGTC_1705 st027868 56.3335 µM -1.54107677657428 0.044114933121552 no 3146 0.0616490506094083 1006 292948 SGTC_2536 dehydroabietamide 32.04 µM -1.54166816058563 0.0440537389977919 no 3147 0.061577126428934 1025 3983547 SGTC_2013 4024628 200 µM -1.54509273525025 0.043700721857057 no 3148 0.0611619169771145 1040 5230760 SGTC_2784 7567673 72.73 µM -1.54552848642973 0.0436559672523285 no 3149 0.0611092420051755 1000 3471247 SGTC_2962 9082311 13.18 µM -1.54908082369129 0.0432924963292845 no 3150 0.0606811460343207 1028 16459453 SGTC_3082 9117008 49.47 µM -1.55600483027609 0.0425910649651169 no 3151 0.0598534718856751 1027 41448529 SGTC_1243 0416-0003 5.65 µM -1.55909875296248 0.0422806219477519 no 3152 0.0594865043863877 1027 2141977 SGTC_2930 9013230 14.89 µM -1.56011621818455 0.042178930811319 no 3153 0.0593662098132358 997 2995857 SGTC_1556 plumbagin 1.48 µM -1.56276359040945 0.0419152649355537 no 3154 0.0590541055175016 980 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_93 0109-0045 59.227 µM -1.56342384900858 0.041849714602163 no 3155 0.0589764671229597 1041 88733 SGTC_767 0929-0023 86 µM -1.56527759100123 0.0416661190826353 no 3156 0.0587589175686859 1031 1204563 SGTC_305 1682-2595 20.8 µM -1.56635346925649 0.0415598631265848 no 3157 0.0586329448974766 1018 226033 SGTC_3275 9138069 49.47 µM -1.57115045691162 0.0410887713538798 no 3158 0.0580738523967761 1034 17617007 SGTC_1840 st055363 71 µM -1.57379002445521 0.040831403265857 no 3159 0.0577680005148178 1045 676033 SGTC_952 1185-0122 232 µM -1.57681119254184 0.0405384344871368 no 3160 0.0574194877540046 1024 678600 SGTC_196 k015-0023 18.111 µM -1.5806644349951 0.0401672563401251 no 3161 0.0569773921681696 1017 5211998 SGTC_86 0417-1630 471.922 µM -1.58232809906156 0.0400078532464705 no 3162 0.0567873446500113 1016 3634867 SGTC_1022 4477-0945 21.3 µM -1.58286921405856 0.0399561175258434 no 3163 0.0567256384722739 1023 4648966 SGTC_394 menadione 8.33 µM -1.58678339523242 0.0395835018296656 no 3164 0.0562808554115054 1031 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3356 9151811 4.48 µM -1.59152897551826 0.0391355354676648 no 3165 0.0557452899076733 1041 1859254 YPR165W RHO1 SGTC_1839 st053978 48 µM -1.59211500497439 0.0390805037122642 no 3166 0.0556794330924399 1041 3788398 SGTC_2911 7942208 15.64 µM -1.59515119296645 0.0387963949344267 no 3167 0.0553392149903511 1002 1243384 SGTC_2137 5261020 140 µM -1.60195039423962 0.0381662655366358 no 3168 0.054583289686157 1028 763655 SGTC_969 1313-0238 134 µM -1.61039520565832 0.0373952738969788 no 3169 0.0536558032893492 1024 5212874 SGTC_1836 st055642 81 µM -1.61870988501272 0.0366486387964886 no 3170 0.0527548495046271 1032 8571 SGTC_674 0498-0004 451 µM -1.62595945403127 0.0360076400799179 no 3171 0.0519791405037861 995 4231473 SGTC_2302 7771753 200 µM -1.6280648328963 0.0358232150385413 no 3172 0.0517555696849127 1013 2203047 SGTC_2054 5233173 129 µM -1.6301728645624 0.035639333761255 no 3173 0.051532483630148 905 6889 SGTC_228 caffeine 993.056 µM -1.63794751344982 0.0349678366907219 no 3174 0.0507163216018505 1027 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2965 9082772 38.63 µM -1.64395324455391 0.0344562603323774 no 3175 0.0500929303003775 889 16459634 SGTC_1959 st077091 55.8 µM -1.65245585630973 0.0337425270338346 no 3176 0.049220828484694 1022 821356 YKL052C ASK1 SGTC_3325 9138760 55.175 µM -1.6529994837634 0.0336973102540426 no 3177 0.0491654843161871 1015 43844959 SGTC_1237 0330-0133 46.1 µM -1.65936883620325 0.0331712377812623 no 3178 0.0485207460067235 1033 X1237 YHR072W ERG7 SGTC_2108 5365811 200 µM -1.67731135841881 0.0317255598552016 no 3179 0.0467408063084651 1032 780283 SGTC_1785 bathophenanthroline 24 µM -1.6821037492059 0.0313483574921764 no 3180 0.0462743617520901 985 72812 An iron chelator. SGTC_2552 juarezic acid 87.02 µM -1.68672992989522 0.0309877625898668 no 3181 0.0458276471297339 1036 1549512 SGTC_1162 k048-0130 20.1 µM -1.68933515129301 0.0307862098016252 no 3182 0.045577610356271 1035 6797406 SGTC_1726 st035556 14.5795 µM -1.69115030414527 0.030646423097715 no 3183 0.0454040498215733 1023 5919439 SGTC_2801 7907800 81.82 µM -1.69887191950178 0.0300576351613013 no 3184 0.0446716594622134 1021 6620925 SGTC_1021 4476-0760 85.3 µM -1.69932418914809 0.030023441523223 no 3185 0.044629058665795 1052 746768 SGTC_2234 tolnaftate 200 µM -1.71269791100077 0.0290268152697206 no 3186 0.043384064830385 1078 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1979 st071809 45.3 µM -1.72594198296845 0.0280670984396268 no 3187 0.0421789253926735 1048 4976333 SGTC_1319 1306-0155 43.7 µM -1.72595307742506 0.0280663057059124 no 3188 0.0421779273311843 1047 3122360 SGTC_2082 5219693 150 µM -1.72687196480073 0.0280007130119526 no 3189 0.0420953301954301 1044 2834649 SGTC_2750 bromebric acid 70.15 µM -1.73348345540643 0.0275325211017736 no 3190 0.0415048878119509 1046 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2485 5633444 17.78 µM -1.738716203861 0.0271666076766894 no 3191 0.0410423471866709 1034 5724239 SGTC_2992 9074591 71.4286 µM -1.74193656473642 0.0269434391069972 no 3192 0.040759772445286 1043 17741321 SGTC_3351 9150312 21.596 µM -1.74320950753866 0.0268556481465009 no 3193 0.0406485126597297 1053 4904905 SGTC_923 1900-2434 73.3 µM -1.7480556016619 0.0265236103100607 no 3194 0.0402271999711205 1036 5910570 SGTC_2388 9080168 200 µM -1.74845476939808 0.0264964142674389 no 3195 0.0401926555831965 1050 15943073 SGTC_1727 st034309 9.9045 µM -1.75090153330225 0.026330220358165 no 3196 0.0399814363235176 1048 870305 SGTC_1335 1486-0900 202 µM -1.75584166182728 0.0259973221540302 no 3197 0.0395577242199539 1042 X1335 SGTC_2028 5153890 36.43 µM -1.75852592651089 0.0258179198963208 no 3198 0.0393290320738637 1054 2830968 YPR165W RHO1 SGTC_2057 5236571 38.335 µM -1.76446373326397 0.0254247463041668 no 3199 0.0388269680501414 1034 54684039 YBR257W POP4 SGTC_2853 9015042 58.44 µM -1.76471098500155 0.0254084838203362 no 3200 0.0388061757195678 1033 6457456 SGTC_1187 1391-0724 117 µM -1.76726601582605 0.0252409414704086 no 3201 0.0385918442117713 1061 6997986 SGTC_1356 1502-0781 85.8 µM -1.77066747598552 0.025019333168984 no 3202 0.0383080069941962 1049 567702 SGTC_1932 st074806 40.9 µM -1.77114275009117 0.024988498885051 no 3203 0.0382684832848149 1034 17251235 SGTC_1480 1070-0044 41.2 µM -1.77365238229324 0.0248262096796614 no 3204 0.0380603337058727 1054 3124987 SGTC_55 0767-0285 6.563 µM -1.77651101929265 0.0246424294181983 no 3205 0.0378243636550915 1034 3116166 SGTC_1766 st045414 44.774 µM -1.78295605455149 0.0242322664576977 no 3206 0.0372967285937655 1035 253960 SGTC_2252 omeprazole 400 µM -1.78606677045308 0.0240363607771474 no 3207 0.0370442238516991 1063 4594 A proton pump inhibitor. SGTC_2991 9074669 71.4286 µM -1.78736693324241 0.023954874773028 no 3208 0.0369391011952507 1038 17333109 SGTC_3154 9100113 49.47 µM -1.78962565831848 0.023813864124064 no 3209 0.0367570554065621 1043 25237525 SGTC_2441 5730946 39.09 µM -1.7936589556007 0.0235638035910858 no 3210 0.0364338101345004 1035 1774275 SGTC_1215 3852-0577 11.2 µM -1.79710550462286 0.0233518744451012 no 3211 0.0361594360033614 1043 2884876 SGTC_1978 st071761 42 µM -1.79793302960927 0.0233012292203141 no 3212 0.0360938105864073 1051 5147680 SGTC_2433 5607874 27.82 µM -1.80136347643861 0.0230922678564137 no 3213 0.035822804453892 1033 2252428 SGTC_3330 9141424 71.43 µM -1.80633680122467 0.0227921277343527 no 3214 0.0354328733782514 1047 27261020 SGTC_863 0466-0191 129 µM -1.80657932521499 0.0227775758660482 no 3215 0.0354139477548403 1060 765160 YPR165W RHO1 SGTC_2596 sinensetin 100 µM -1.81999881256401 0.0219844970764852 no 3216 0.0343795928612513 1042 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3138 9097216 49.47 µM -1.82147694998579 0.0218985833734012 no 3217 0.034267193693084 1055 25237486 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.82677122457829 0.0215931872603226 no 3218 0.0338670870608628 1074 91467 include heat shock SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.83062020036132 0.0213734282613214 no 3219 0.0335786256639299 1041 688667 SGTC_2873 9040596 71.43 µM -1.83262752252501 0.0212595715268634 no 3220 0.0334289911520703 1061 6463863 SGTC_1745 st081495 74 µM -1.83316657009039 0.0212290838818015 no 3221 0.0333889018499506 1032 13842402 YBL026W LSM2 SGTC_2192 5915882 198.485 µM -1.83631912040254 0.0210515204214027 no 3222 0.0331552367672144 1057 2876149 SGTC_1113 artemisinin 1.17947 µM -1.84152501430783 0.0207610562974967 no 3223 0.0327723291785096 1022 2240 An anti-malaria and mitochondrial poison. SGTC_430 0958-0115 16.4 µM -1.84508494070937 0.0205643890882466 no 3224 0.0325125917415858 1049 6833180 SGTC_2659 sanguinarine 24.21 µM -1.84573080991539 0.0205288778866831 no 3225 0.0324656506515849 1007 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2200 6600604 21.907 µM -1.8510612095751 0.0202377806309604 no 3226 0.0320803738963892 1066 2904777 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.85659988360433 0.0199390243727586 no 3227 0.0316840502604985 1048 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3013 9080133 71.4286 µM -1.86096687021872 0.0197061150246974 no 3228 0.0313744276765023 1055 17050193 SGTC_2783 7738165 71.43 µM -1.86120903968712 0.0196932670068991 no 3229 0.0313573311545455 1056 17201110 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.8638643113877 0.0195528605363782 no 3230 0.0311703808141622 1038 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_82 0054-0107 293.755 µM -1.87224360498575 0.0191153391525716 no 3231 0.0305864544718997 1057 3104697 SGTC_642 0335-0876 158 µM -1.88527128281475 0.018451645596283 no 3232 0.0296966105964833 1065 6812350 SGTC_517 1365-0151 113 µM -1.88533600303935 0.0184483980561418 no 3233 0.0296922441465913 1054 768657 SGTC_3005 9076496 71.4286 µM -1.8858673573468 0.0184217540875769 no 3234 0.0296564156456233 1061 21368410 SGTC_1057 3448-5381 134 µM -1.88930243505242 0.0182502968554577 no 3235 0.0294256577285803 1000 5497911 SGTC_3099 9120367 49.47 µM -1.88951743745941 0.0182396106697545 no 3236 0.0294112642426036 1061 24824940 SGTC_363 0455-0021 3.06 µM -1.89630026991523 0.0179052129097846 no 3237 0.0289601753079953 1019 4597466 SGTC_2398 5228213 48.84 µM -1.9042042564828 0.0175221513644209 no 3238 0.0284417938009425 1060 80771 YMR134W ERG29 SGTC_398 bronopol 33.3 µM -1.91047340695483 0.0172233169055031 no 3239 0.0280361436014164 1060 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1697 st025554 27.742 µM -1.91280206419087 0.0171134302497367 no 3240 0.0278866984063565 1059 1269519 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.91484625269566 0.0170174617331214 no 3241 0.027756056943497 1055 5282362 SGTC_1723 st034307 2.5525 µM -1.91740972096575 0.0168977651011764 no 3242 0.0275929501141497 1049 867466 SGTC_1109 tnp00067 928.257 nM -1.94813703548751 0.0155181409352352 no 3243 0.0256992841849895 1060 676295 SGTC_691 1548-0686 185 µM -1.95894516279081 0.0150564116479709 no 3244 0.0250596045889706 1051 46495133 SGTC_3148 9097893 49.47 µM -1.9717775986835 0.0145235787526628 no 3245 0.024317500341681 1043 17174100 SGTC_2117 5521686 200 µM -1.99154678514547 0.0137344940293507 no 3246 0.0232104035414773 1064 803312 SGTC_1789 tunicamycin 25 nM -1.99273949888156 0.0136880932524431 no 3247 0.023144989892677 1033 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2990 9074105 71.4286 µM -1.99685601004426 0.0135289838964756 no 3248 0.0229204135270236 1069 6502001 SGTC_397 arbidol 50 µM -1.99966341447426 0.013421391357307 no 3249 0.0227683106436843 1068 131410 A RNA synthesis inhibitor. SGTC_2541 muurolladie-3-one 83.07 µM -2.00959411182112 0.0130467097642097 no 3250 0.0222370824819714 1030 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1394 3474-0001 65.7 µM -2.02197736945503 0.012592188816904 no 3251 0.0215893449234181 1073 5017666 YIL048W NEO1 SGTC_367 0335-0881 7.1 µM -2.02739091458531 0.0123978335458057 no 3252 0.0213112251770532 1066 23828853 SGTC_1020 4335-0961 93.3 µM -2.03350265161081 0.0121815394792936 no 3253 0.0210008829764952 1067 669075 SGTC_1885 st057546 99.9 µM -2.038931542693 0.0119921617448484 no 3254 0.0207284301545816 1056 702008 SGTC_1870 st057514 26.5 µM -2.05391516228714 0.0114826737780756 no 3255 0.0199919517788669 1067 5393161 SGTC_1098 clofazimine 15.1 µM -2.06677120386325 0.0110606224277285 no 3256 0.0193778590512689 1067 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2036 5160441 105 µM -2.07602724521927 0.0107651707956221 no 3257 0.0189457156083688 1047 134534 YIL048W NEO1 SGTC_1629 st005085 44.9 µM -2.08214235732307 0.0105737677236943 no 3258 0.0186647342803359 1056 24207091 SGTC_208 k072-0098 12.366 µM -2.08276967373108 0.0105543014036029 no 3259 0.0186361115535669 1062 5948901 SGTC_797 k781-0471 270 µM -2.08302254211506 0.0105464634525878 no 3260 0.0186245844336877 1051 23738129 SGTC_1164 k060-0068 93.7 µM -2.08915379590755 0.0103579641259869 no 3261 0.018346940540108 1078 5963676 SGTC_3243 9134147 49.47 µM -2.09058842362394 0.0103142843139536 no 3262 0.0182824871846291 1058 24282180 SGTC_2238 6671620 73.2395 µM -2.09840033098052 0.0100792441758459 no 3263 0.0179348980400301 1053 729941 SGTC_3279 9140807 49.47 µM -2.10172014040497 0.00998078340979995 no 3264 0.0177888991244642 1074 45595718 SGTC_917 harmaline 728.087 nM -2.1089940180519 0.00976798131427504 no 3265 0.0174725489891815 1051 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1036 k216-0215 33.5 µM -2.10931316513422 0.00975873591312952 no 3266 0.0174587795840072 979 622330 SGTC_2951 9072950 58.06 µM -2.11118087490318 0.00970478318174592 no 3267 0.017378384023046 1051 16488155 SGTC_127 0180-0333 59.125 µM -2.12180335317682 0.00940285978033919 no 3268 0.0169271274760528 1023 771601 SGTC_433 pimozide 108 µM -2.12276948951279 0.00937581123828905 no 3269 0.0168865863573869 1078 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1515 3460-0031 42.1 µM -2.12978674520329 0.00918138630784603 no 3270 0.0165946117410287 1064 2876596 SGTC_1453 4237-0541 195 µM -2.15498286486827 0.00851207086363334 no 3271 0.015581587562281 1055 739892 SGTC_840 0245-0196 390 µM -2.15590788842851 0.00848833501774241 no 3272 0.0155454291936706 1081 3827528 SGTC_464 bw-b 70c 158 µM -2.16223701866248 0.0083274840080234 no 3273 0.0152999557545729 1078 5353454 SGTC_85 0868-0259 160.055 µM -2.16232049252191 0.00832538057645042 no 3274 0.0152967406165694 1060 83173 SGTC_2700 st077718 96.8 µM -2.16328179245457 0.00830119068375047 no 3275 0.0152597563097577 1076 904970 SGTC_1594 piperine 70.1 µM -2.17950212397781 0.00790223388954772 no 3276 0.014647193527195 1079 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1310 1188-0297 994 nM -2.17954146206747 0.00790128719172904 no 3277 0.0146457340225468 1038 1588352 SGTC_834 0312-0008 75.7 µM -2.19222625667563 0.00760117269341123 no 3278 0.0141815867252762 1079 6385573 YIL048W NEO1 SGTC_2418 pentamidine 31.67 µM -2.19797274823639 0.00746855007747987 no 3279 0.0139755240045342 1032 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3146 9095609 49.47 µM -2.19882739744799 0.00744900087201483 no 3280 0.0139450988034133 1069 17173999 SGTC_1837 st055472 66.5 µM -2.20206205544964 0.00737541909313471 no 3281 0.0138304626616396 1073 676091 SGTC_1221 2958-7315 257 µM -2.21503288951608 0.00708675489226255 no 3282 0.0133789035609419 1077 4562705 SGTC_3009 9080819 71.4286 µM -2.22078434758 0.00696197945091602 no 3283 0.0131827856183096 1079 17027216 SGTC_2142 5622915 118.518 µM -2.22853998292345 0.00679679691371416 no 3284 0.0129222640929662 1074 5322196 SGTC_202 3594-0513 34.79 µM -2.23204068770027 0.006723378494391 no 3285 0.0128061369561199 1085 708429 SGTC_867 0518-0118 155 µM -2.23750076703825 0.00661026581811762 no 3286 0.0126268146237824 1068 6848158 SGTC_966 1300-0360 30.2 µM -2.27119391777229 0.00594876903747529 no 3287 0.011567620732776 1038 70588 SGTC_73 0327-0325 16.231 µM -2.27395950783407 0.00589717291792947 no 3288 0.0114842106139126 1008 53298 SGTC_2862 9027634 71.43 µM -2.28383682289157 0.00571612247856278 no 3289 0.0111905613464399 1063 5012562 SGTC_2066 5222451 176 µM -2.29187742054117 0.00557239985201636 no 3290 0.0109563587676165 1027 2281147 SGTC_1193 1488-0126 41.5 µM -2.29942671381355 0.00544039006949626 no 3291 0.0107403602312957 1076 1384710 SGTC_722 3534-0461 190 µM -2.29949021034028 0.00543929163441599 no 3292 0.0107385593213451 1073 658262 SGTC_50 0929-0078 56.389 µM -2.30338556410677 0.00537228120417035 no 3293 0.01062857962293 1061 1377751 SGTC_2047 4141938 200 µM -2.30474572192029 0.00534905635063842 no 3294 0.0105904092908547 1082 3807862 SGTC_1471 k673-0312 37 µM -2.31075427045156 0.00524752451346399 no 3295 0.0104232158549705 1081 24099884 SGTC_710 3448-4187 58 µM -2.33210624758881 0.00490045207684661 no 3296 0.00984755123473674 1085 3946412 SGTC_828 2074-0507 139 µM -2.35128430727814 0.0046063125699904 no 3297 0.0093543664265937 1073 X828 SGTC_3098 9119039 49.47 µM -2.36679198613725 0.0043800987400442 no 3298 0.00897150722148782 1076 17161528 SGTC_1094 duloxetine 25.4 µM -2.38964629615932 0.00406479872954778 no 3299 0.00843230285941081 1079 60834 A selective serotonin reuptake inhibitor. SGTC_2016 5121758 140 µM -2.41602350723801 0.00372627048823296 no 3300 0.007845524150962 1073 2795203 SGTC_2363 9053361 176 µM -2.43281739957754 0.0035241327022906 no 3301 0.00749092710348207 1083 6469797 YMR079W SEC14 SGTC_1468 k284-1086 134 µM -2.46204143903674 0.00319573891811763 no 3302 0.00690743521128052 1079 15996457 SGTC_1679 SEC14.276 6.7 µM -2.46482924580949 0.00316589781969446 no 3303 0.00685392798434497 1067 1005053 YMR079W SEC14 SGTC_2539 epi(13)torulosol 80 µM -2.47026981097774 0.00310838247748275 no 3304 0.00675055893054115 1054 6708597 SGTC_2195 6536160 144.242 µM -2.47729588756864 0.00303549831848731 no 3305 0.00661910519898227 1084 3834386 SGTC_2049 5262831 67.185 µM -2.48121051858706 0.00299556152861087 no 3306 0.00654685082343562 1070 763417 SGTC_872 0588-0139 234 µM -2.4988338878211 0.00282156964861889 no 3307 0.00623013510890309 1085 2047100 SGTC_954 1189-0853 2.85 µM -2.49937326360335 0.00281639130902383 no 3308 0.00622065955980643 1070 2828194 SGTC_43 0570-0105 72.5 µM -2.49948425083849 0.002815326827429 no 3309 0.0062187113622614 1078 1114046 YDL195W SEC31 SGTC_852 0418-0143 439 µM -2.52820359604135 0.00255177168719224 no 3310 0.00573239233155234 1043 5369229 SGTC_2144 5628481 200 µM -2.53631194660289 0.00248151142233129 no 3311 0.00560134463849244 1084 2818399 SGTC_2241 6772625 37.8075 µM -2.54407272253865 0.0024159064244548 no 3312 0.00547841351807338 1061 2285411 SGTC_547 1120-0019 610 nM -2.54777791372237 0.00238514185238222 no 3313 0.0054205731536925 1045 3676939 SGTC_481 bay k-8644 50 µM -2.54938653051399 0.00237189607152086 no 3314 0.00539563107359345 1082 2303 A calcium channel antagonist. SGTC_252 miconazole 1.30953 nM -2.5842183689062 0.00210093302052283 no 3315 0.00487999889519073 1067 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2351 9026858 72.31 µM -2.5930773988392 0.00203665335993894 no 3316 0.00475606804804895 1081 1409300 SGTC_2236 dapsone 200 µM -2.61177402130621 0.00190681582882029 no 3317 0.00450368854366719 1090 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1994 st072947 40.9 µM -2.62753313203627 0.00180326967182429 no 3318 0.00430032329113295 1085 5286565 YDL195W SEC31 SGTC_2397 5161689 200 µM -2.63920917654773 0.00172987892843164 no 3319 0.00415498444244808 1081 2259942 SGTC_2835 9006588 71.43 µM -2.66526173997538 0.00157582682115445 no 3320 0.00384642111622054 1056 2345538 SGTC_2925 9010536 32.5 µM -2.69237379428944 0.00142888130224687 no 3321 0.00354726905433367 1010 2994177 SGTC_1748 st037455 53.6035 µM -2.69508736596542 0.00141488487925425 no 3322 0.00351850886330924 1086 580690 SGTC_91 0417-1751 58.384 µM -2.80581433699341 0.000940053677417136 yes 3323 0.00250948009022817 1092 6795624 SGTC_288 1315-0019 35.1 µM -2.83698859073695 0.00083571276691888 yes 3324 0.00227706196743483 1078 6811474 SGTC_1787 fluconazole 80 µM -2.86683051195011 0.000745916741737703 yes 3325 0.00207302493230845 1077 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_842 0271-0008 11.1 µM -2.87419547576449 0.000725167272676892 yes 3326 0.00202529088987005 1079 1221709 SGTC_1364 1653-0028 37.6 µM -2.92534701300746 0.000595106782765944 yes 3327 0.00172036154098189 1091 5718652 SGTC_147 4466-0538 29.23 µM -2.93390133646872 0.000575587047659213 yes 3328 0.00167365296508384 1090 6742687 YHR072W ERG7 SGTC_407 eburnamonine 100 µM -2.9609050349129 0.000517783986706504 yes 3329 0.0015336825114923 1084 3195 SGTC_777 1315-0167 517 µM -2.97451480904569 0.000490732827751604 yes 3330 0.00146726145450003 1082 4221767 SGTC_2739 tacrine 100.86 µM -2.98631369038017 0.000468346319327461 yes 3331 0.00141181417529818 1017 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_785 1270-0111 65.3 µM -3.10485141568988 0.000290376601050305 yes 3332 0.000951873159612152 1088 6741994 SGTC_905 2-aminofluorene 215 µM -3.11728412199479 0.00027591632563731 yes 3333 0.000912627850873253 1089 1539 An established DNA mutagen. YPR165W RHO1 SGTC_902 1120-0002 2.07 µM -3.20690831627162 0.000189911204271024 yes 3334 0.00067084874568311 1077 3280475 SGTC_2830 7992007 71.43 µM -3.2748192818542 0.000142208164131842 yes 3335 0.000528647933328253 1087 1952075 SGTC_1527 coumarin 137 µM -3.314105376757 0.000120001081916749 yes 3336 0.000459684260072629 1087 323 A hepatotoxic, DNA x-linker. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -3.32199079848604 0.000115955180281548 yes 3337 0.000446888206274368 1089 6708514 SGTC_2342 7990637 118.86 µM -3.3949066437044 8.41518707002043e-05 yes 3338 0.000343260027675902 1091 2033102 YER133W GLC7 SGTC_2601 securinine 100 µM -3.42941484795939 7.21494184167899e-05 yes 3339 0.000302442101616085 1089 442872 A GABA receptor antagonist. SGTC_3093 9117344 49.47 µM -3.50893415896221 5.03415191703813e-05 yes 3340 0.000224953133176902 1093 24824913 SGTC_1218 1348-1416 30.7 µM -3.58821869238152 3.49041753378897e-05 yes 3341 0.000166472483993631 1090 6787668 SGTC_145 3737-0113 38.366 µM -3.65984321714027 2.49137890572581e-05 yes 3342 0.000126184806075802 1093 6849351 SGTC_2330 7979373 200 µM -3.71877664403855 1.87925340121805e-05 yes 3343 0.000100094983091341 1088 1863007 SGTC_383 2324-0395 7.37 µM -3.7236390437267 1.83570455963427e-05 yes 3344 9.81858150392735e-05 1083 3146421 SGTC_1565 sinapyl alcohol 95.1 µM -3.76179323399218 1.5257482141143e-05 yes 3345 8.43497428352052e-05 1087 5280507 A phenol propionate derived from cinnamic acid. SGTC_217 ketoconazole 989 nM -3.76937794067139 1.47037218847171e-05 yes 3346 8.18274587599664e-05 1089 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1718 roemerine 11.9335 µM -3.83557476883377 1.06181637522647e-05 yes 3347 6.26354940857107e-05 1081 235224 An aporphine alkaloid with mutagenic activity. SGTC_227 fluconazole 33.516 µM -4.20281303862726 1.58814535806223e-06 yes 3348 1.31809157578076e-05 1095 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1353 1498-1206 8.11 µM -4.28114029411976 1.03732451439463e-06 yes 3349 9.29690422155685e-06 1059 6756808 SGTC_778 3456-2434 196 µM -4.70360588602005 9.19536960013566e-08 yes 3350 1.27803217890637e-06 1054 5539063 SGTC_141 0443-0274 32.331 µM -4.90489623221472 2.68923875094507e-08 yes 3351 4.67383716612093e-07 1037 1627241 SGTC_1463 k081-0032 34.1 µM -4.98851342509569 1.59088374481011e-08 yes 3352 3.042284192308e-07 1070 977755 SGTC_1347 1493-0251 600 nM -5.51139194992536 4.9357879753033e-10 yes 3353 1.78003474992777e-08 1088 3986378 SGTC_2640 pentamidine 10.38 µM -5.53519900530195 4.18106755584598e-10 yes 3354 1.5543758807183e-08 1094 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_490 phenamil 164 µM -5.7038740746371 1.26526688858795e-10 yes 3355 5.85573055254525e-09 1076 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1462 k081-0014 26.5 µM -6.59758317711535 1.26750796031545e-13 yes 3356 2.0895711909091e-11 1072 3270634