SGTCid condition conc unit RPL34B|YIL052C.score RPL34B|YIL052C.strain.pval RPL34B|YIL052C.strain.significant RPL34B|YIL052C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2233 sulbentine 40.3845 µM 21.2442723944873 1.24602384941513e-71 yes 1 1.862137591047e-100 2 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2651 TUB2.036 5 µM 14.9703948262781 1.23907498140014e-36 yes 2 5.7319322007619e-51 6 15992207 YFL037W TUB2
SGTC_1304 1165-0502 251 µM 13.6541382706377 8.16846462433468e-31 yes 3 9.53661088603933e-43 2 767425
SGTC_1750 st081859 2.357 µM 13.4417929078288 6.33129731357903e-30 yes 4 1.7199981913771e-41 27 5291695
SGTC_18 0111-0177 500 nM 12.9472324648732 6.60161927077541e-28 yes 5 1.21788976509959e-38 3 721752
SGTC_1844 rapamycin 4 nM 12.1981409948314 5.4306515226948e-25 yes 6 1.59000613286577e-34 23 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_87 0100-0052 35.5 µM 10.2010729478939 4.72393025679814e-18 yes 7 9.80470318484242e-25 5 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_312 4092-0653 6.84 µM 10.1746096770143 5.72985366841489e-18 yes 8 1.28714995317857e-24 12 1148278
SGTC_2688 kanamycin b 96.69 µM 10.1284249126161 8.01598363381484e-18 yes 9 2.06626189545678e-24 24 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_568 1193-0097 7.48 µM 10.1272475638384 8.08472920115939e-18 yes 10 2.09128604256605e-24 24 3646150
SGTC_1226 3909-7979 35.4 µM 9.95947211488911 2.70315272389643e-17 yes 11 1.14638426627791e-23 6 6615510
SGTC_514 4466-0038 2.65 nM 9.92178032878637 3.53561522100282e-17 yes 12 1.67365758253859e-23 22 5722064
SGTC_8 0354-0001 70 µM 9.62882728059896 2.75441330157413e-16 yes 13 3.02075046426753e-22 4 4993152
SGTC_46 0329-0187a 2.197 µM 9.35738778858413 1.74971535164588e-15 yes 14 4.08661727744526e-21 9 46494817
SGTC_163 TUB2.036 7.546 µM 8.92691153135202 2.95615909395707e-14 yes 15 2.19033742834993e-19 16 15992207 YJR013W GPI14
SGTC_2912 7964298 10.93 µM 8.8662585709419 4.35734521024468e-14 yes 16 3.78223501807242e-19 21 2975850
SGTC_690 glyoxal 20.3 µM 8.7110546653863 1.1623271659838e-13 yes 17 1.50530212308053e-18 22 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1877 wortmannin 25 µM 8.27478419440548 1.67579436028759e-12 yes 18 6.43442404172884e-17 22 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2679 rapamycin 1 nM 8.12833474556042 3.9847401588097e-12 yes 19 2.17613970802019e-16 41 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2408 sulbentine 18.36 µM 8.06516412919588 5.76332193391107e-12 yes 20 3.65687708804747e-16 12 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_528 3492-0019 172 µM 8.00555495109485 8.14347525272765e-12 yes 21 5.94645543887033e-16 70 2869262
SGTC_201 4262-0159 12.803 µM 7.85913971349316 1.8838733205654e-11 yes 22 1.93390317311545e-15 13 1341029
SGTC_103 0844-0104 51.839 µM 7.63341509160508 6.66777980158984e-11 yes 23 1.14307647331762e-14 51 5375804
SGTC_2619 obliquin 87.91 µM 7.60394085959976 7.84385624707164e-11 yes 24 1.43623280005327e-14 49 6708593 A bioactive alkalod. YER133W GLC7
SGTC_262 fenpropimorph 62.5 µM 7.56954420679958 9.47393963705804e-11 yes 25 1.87267997601259e-14 8 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_59 0330-0160 1.33 µM 7.35299956268357 3.05226990962088e-10 yes 26 9.69037858538895e-14 18 4293482
SGTC_710 3448-4187 58 µM 7.2671081753851 4.81131147585075e-10 yes 27 1.83632349042402e-13 10 3946412
SGTC_3311 9131146 2.8755 µM 7.01280339637846 1.79673506256962e-09 yes 28 1.1679479536176e-12 47 4900406 YPR165W RHO1
SGTC_138 0850-0259 40.9225 µM 6.91833749626634 2.89813465478391e-09 yes 29 2.28487290455477e-12 76 6813004
SGTC_2430 5571206 200 µM 6.91677779946989 2.9209516531307e-09 yes 30 2.31015956159898e-12 16 1731771
SGTC_1161 k007-0610 110 µM 6.88992675068705 3.34228361850153e-09 yes 31 2.79105616926579e-12 41 5843850
SGTC_320 4092-0846 5.34 µM 6.77687901203629 5.86214642574521e-09 yes 32 6.13998186540655e-12 9 1359356
SGTC_1712 st032288 53.4 µM 6.67112512435581 9.83722385659866e-09 yes 33 1.2692483509115e-11 60 2883011
SGTC_7 0192-1582 4.227 µM 6.50404984661515 2.19406960188954e-08 yes 34 3.90929850373981e-11 19 252616
SGTC_1019 4262-0212 3.4 µM 6.43063531273056 3.10241888095453e-08 yes 35 6.35358512195364e-11 20 4677213
SGTC_3321 9137793 26.8275 µM 6.40745915323255 3.45829888288284e-08 yes 36 7.3982355079813e-11 27 4904192
SGTC_916 4466-0038 42 nM 6.28732707548615 6.03617833450858e-08 yes 37 1.61489225570823e-10 25 5722064 YGL116W CDC20
SGTC_1597 7-benzyloxygramine 47.5 µM 6.23861881400277 7.54429106242086e-08 yes 38 2.20725629085563e-10 47 260807
SGTC_1752 st044819 83.042 µM 6.13905865856083 1.18413105698628e-07 yes 39 4.15059563845214e-10 9 441209 YML126C ERG13
SGTC_2505 galangin 7.89 µM 6.11256829207846 1.33350927741775e-07 yes 40 4.90201648666525e-10 3 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2278 7948257 134.34 µM 6.09911724356223 1.41616992549435e-07 yes 41 5.33279109509511e-10 4 1247028
SGTC_492 tmb-8 126 µM 6.02131953582863 2.00045880378713e-07 yes 42 8.65004193042913e-10 2 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2778 tioconazole 65.09 nM 5.55902720033681 1.43070455516816e-06 yes 43 1.3564121082399e-08 33 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2322 7413319 38.22 µM 5.52052578047479 1.67439328597623e-06 yes 44 1.68993399372646e-08 73 1840400
SGTC_887 0885-0007 9.62 µM 5.51623966735607 1.7038628337458e-06 yes 45 1.7316494244022e-08 15 5719458
SGTC_1072 oxiconazole 14.9 nM 5.35793931018929 3.21726681723252e-06 yes 46 4.20882520321114e-08 29 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3107 9121808 49.47 µM 5.21420197988534 5.64607475093048e-06 yes 47 9.23051170888555e-08 1 662681
SGTC_2976 9009005 19.48 µM 5.19066334009948 6.18254817198892e-06 yes 48 1.0477310271535e-07 16 2993148
SGTC_3059 1327-0034 3 µM 5.13454436384045 7.66468787367702e-06 yes 49 1.41414187679589e-07 33 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2601 securinine 100 µM 5.03064993515953 1.13456879134701e-05 yes 50 2.4440997224986e-07 12 442872 A GABA receptor antagonist.
SGTC_3027 9089541 49.47 µM 4.96269333697752 1.46060517702428e-05 yes 51 3.47611526299342e-07 6 9943819
SGTC_1976 st070609 63.5 µM 4.95392720648368 1.50863904164864e-05 yes 52 3.63652120584513e-07 1 682556
SGTC_2495 cafestol 54.53 µM 4.85259271833433 2.18471426318898e-05 yes 53 6.09288906828021e-07 14 16667697 An anti-infammatory.
SGTC_2060 5238662 140 µM 4.80092787390645 2.6316327507723e-05 yes 54 7.89660739453866e-07 14 790130
SGTC_2602 kawain 100 µM 4.66298640022107 4.28760141401379e-05 yes 55 1.558266780803e-06 14 5369129
SGTC_852 0418-0143 439 µM 4.50456071026526 7.39322047080826e-05 yes 56 3.32551911207774e-06 49 5369229
SGTC_467 ro 31-8220 72.8 µM 4.46499741707589 8.44857355699279e-05 yes 57 4.00348588754667e-06 57 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3114 9122766 49.47 µM 4.41937394005102 9.84112011891377e-05 yes 58 4.94936204937913e-06 10 17176985
SGTC_902 1120-0002 2.07 µM 4.40469189459331 0.000103333060498201 yes 59 5.29671659136125e-06 35 3280475
SGTC_2594 a-mangostin 100 µM 4.32445223347036 0.000134575511670798 yes 60 7.64556651964859e-06 22 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1531 st059297 52.4 µM 4.30175050505047 0.000144905850900153 yes 61 8.47270268959677e-06 6 7566702
SGTC_1506 4226-2149 212 µM 4.24651094172107 0.000173228122544825 yes 62 1.08562590827648e-05 21 991114
SGTC_2057 5236571 38.335 µM 4.20346898316393 0.000198800764619832 yes 63 1.31427592585649e-05 25 54684039 YBR257W POP4
SGTC_221 trifluoperazine 10.304 µM 4.20139128677601 0.000200120277577593 yes 64 1.32639814647189e-05 194 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2648 atorvastatin 78.68 µM 4.19475578488171 0.000204389380812269 yes 65 1.36582870179167e-05 20 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1557 sumaresinolic acid 42.3 µM 4.14752778350929 0.000237321965855047 yes 66 1.68042347750362e-05 14 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1041 0206-0046 107 µM 4.14713733435163 0.000237613783676541 yes 67 1.68329070588172e-05 28 50494
SGTC_1552 6-methylflavone 10.6 µM 4.11742593374397 0.000260827864582258 yes 68 1.91563800058055e-05 12 689013
SGTC_2221 6807166 181.081 µM 4.09325712457816 0.0002812524826755 yes 69 2.12677794187218e-05 3 674925
SGTC_2584 androsterone 48.74 µM 3.99532332731446 0.000380229327250442 yes 70 3.23030104288585e-05 127 2754130 A steroid.
SGTC_1237 0330-0133 46.1 µM 3.99261035805579 0.000383383852578521 yes 71 3.26749512439308e-05 23 X1237 YHR072W ERG7
SGTC_2187 6125751 200 µM 3.97760307794522 0.0004012770554747 yes 72 3.48067242547799e-05 18 874498
SGTC_2858 9025781 8.96 µM 3.95437871168258 0.000430500883979632 yes 73 3.83668926355193e-05 99 4894980 YPL153C RAD53
SGTC_1309 pyrazolanthrone 13.4 µM 3.93958408257752 0.000450133627454816 yes 74 4.08114958877385e-05 21 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2792 7535235 81.82 µM 3.87936608974905 0.000538917470852243 yes 75 5.23645181949762e-05 33 1281891
SGTC_2249 haloperidol 116.36 µM 3.87927978856088 0.000539055596794868 yes 76 5.23830982163362e-05 119 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1646 st011709 75.6 µM 3.86695801034998 0.00055911626213268 yes 77 5.51006967377305e-05 12 5757843
SGTC_2223 6903751 107.57 µM 3.85900138549574 0.000572434587765274 yes 78 5.69256461990371e-05 12 5598863
SGTC_1959 st077091 55.8 µM 3.8528658409037 0.000582904255251835 yes 79 5.83716811960124e-05 52 821356 YKL052C ASK1
SGTC_1873 rapamycin 2 nM 3.84600962086738 0.000594812873569297 yes 80 6.00285253209793e-05 73 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1895 st058434 18.3 µM 3.7993394424698 0.000682037968972857 yes 81 7.25411338893108e-05 16 5393175
SGTC_3063 1327-0034 4 µM 3.77982231831346 0.0007218978281264 yes 82 7.84701566834623e-05 50 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_564 3555-0129 330 µM 3.6991326855262 0.000910540279798682 yes 83 0.000108168743279272 7 563260
SGTC_1941 st076221 61.8 µM 3.69383410178008 0.000924388766200998 yes 84 0.000110448973443961 91 2828568
SGTC_858 0438-0351 2.77 µM 3.67455671879322 0.000976421262521422 yes 85 0.000119131356636304 27 2799119
SGTC_217 ketoconazole 989 nM 3.67368315549657 0.000978841625998327 yes 86 0.000119539581874769 33 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3195 9113082 49.47 µM 3.67092188928586 0.000986528475270387 yes 87 0.000120838597999692 26 17018038
SGTC_3106 9121286 49.47 µM 3.61972042158384 0.0011394842419504 no 88 0.000147460746812893 21 15943471
SGTC_34 0469-0683 81.75 µM 3.61343416701863 0.00115969098814379 no 89 0.000151084051140487 35 3690923
SGTC_1475 4092-1048 11.7 µM 3.58707433388704 0.00124804608087823 no 90 0.000167204507871943 43 2881759
SGTC_28 pentachloropyridine N-oxide 1.606 µM 3.57665255358562 0.00128464616575774 no 91 0.000174011125314987 91 140250 A respiratory chain inhibitor.
SGTC_3180 9109287 49.47 µM 3.50841711904468 0.00154955751697243 no 92 0.000225390833544205 22 18891271
SGTC_1500 4488-1866 171 µM 3.49944339270429 0.00158787854881596 no 93 0.00023311529401547 34 2900003
SGTC_2801 7907800 81.82 µM 3.46550871149322 0.00174072843470087 no 94 0.000264614690607377 46 6620925
SGTC_2215 7188065 200 µM 3.4218074791517 0.00195726738525712 no 95 0.000311031717912618 13 940217
SGTC_1134 3477-0009 42.5 µM 3.40021774299205 0.00207303062610399 no 96 0.000336661057883274 66 3973534
SGTC_2714 st079313 56.9 µM 3.39161671536778 0.00212085421482619 no 97 0.00034740781433568 17 2939799
SGTC_586 0957-0265 8.15 µM 3.34647610827618 0.00238864612438693 no 98 0.000409228661649655 59 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_177 1327-0068 8.361 µM 3.32981611634009 0.0024949687957163 no 99 0.000434516775190894 70 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2004 4023728 41.89 µM 3.31797663074858 0.00257310904409058 no 100 0.000453360351248101 55 360084 YDR527W RBA50
SGTC_3093 9117344 49.47 µM 3.31739728133169 0.00257698888771947 no 101 0.000454301592321739 36 24824913
SGTC_732 3970-1727 52.7 µM 3.27448624336548 0.00287948783561015 no 102 0.000529271464960948 20 1275699
SGTC_1627 st003713 25.6 µM 3.26873339955328 0.00292238860546918 no 103 0.000540150189700054 119 16195070 YER133W GLC7
SGTC_211 3455-0679 143.504 µM 3.2539399877046 0.00303536586385804 no 104 0.000569081604848638 48 748649
SGTC_178 4092-0806 87.505 µM 3.24439593745399 0.0031103263692792 no 105 0.000588500076177934 136 2169044
SGTC_55 0767-0285 6.563 µM 3.2355573130852 0.00318122846242151 no 106 0.000607027548929934 73 3116166
SGTC_2752 diclazuril 33.15 µM 3.21724844932639 0.003332745000555 no 107 0.000647132335480879 180 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1963 st076565 50.3 µM 3.21347280813559 0.00336478602507861 no 108 0.00065570107401654 38 4914280
SGTC_1327 1436-0082 2.18 µM 3.19419086877496 0.00353277498215779 no 109 0.000701116867024822 49 15992205
SGTC_445 e6 berbamine 66 µM 3.18848976091323 0.00358386691402674 no 110 0.00071509037429966 168 6610268 A calcium/calmodulin antagonist.
SGTC_2982 9019404 25.97 µM 3.18722635092964 0.00359527867230272 no 111 0.000718221561608166 46 22333232
SGTC_2431 5490079 200 µM 3.14003171541579 0.00404562998495487 no 112 0.000844647725521423 75 5722345
SGTC_354 2783-3500 4.88 µM 3.12136792190453 0.00423723251455645 no 113 0.000900064884591171 87 6740761
SGTC_2536 dehydroabietamide 32.04 µM 3.11652443499297 0.00428826384147642 no 114 0.000914982571391345 83 3983547
SGTC_3322 9139058 2.11 µM 3.11230248851838 0.00433319403952909 no 115 0.000928170921510502 66 4908926 YPR165W RHO1
SGTC_2738 aclarubicin 5.55 µM 3.11006545993543 0.0043571707568009 no 116 0.000935229432735319 21 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3350 9150499 3.57 µM 3.08402749389873 0.00464509620821583 no 117 0.00102109360857208 98 4910996 YPR165W RHO1
SGTC_72 0744-0168 198.391 µM 3.07363181677671 0.00476471363837814 no 118 0.00105735120665037 63 677577
SGTC_1467 k284-1082 293 µM 3.07285366825092 0.00477377691175347 no 119 0.00106011213951151 54 3334705
SGTC_1933 st074711 15.9 µM 3.07228646876382 0.00478039289691183 no 120 0.00106212877240852 89 17250958
SGTC_3351 9150312 21.596 µM 3.06704822678953 0.00484188079849421 no 121 0.0010809198752281 65 4904905
SGTC_3208 9114115 49.47 µM 3.04348715878824 0.00512725087985313 no 122 0.0011692671070498 86 650895
SGTC_451 chloral hydrate 100 µM 3.03873073082108 0.00518664430046957 no 123 0.00118788549465724 107 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3200 9114385 49.47 µM 3.03707029339538 0.00520752186351158 no 124 0.00119444869937332 87 17018030 YLR208W SEC13
SGTC_253 dyclonine 31.25 µM 3.02611626184607 0.00534713632424213 no 125 0.0012385851665521 77 3180 An oral anasthetic.
SGTC_1311 1190-0148 100 µM 2.99982699696381 0.00569587142321852 no 126 0.00135066495386007 68 1961333
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.99353926309779 0.00578221492368761 no 127 0.00137881012306228 84 4174840
SGTC_577 r071-0003 38.6 µM 2.96383192693925 0.00620605896581606 no 128 0.00151917092888519 123 4568517 YMR134W ERG29
SGTC_1742 st038235 28.8875 µM 2.95686648917384 0.0063093335190598 no 129 0.00155391327114084 174 564103 YBR002C RER2
SGTC_1824 st053723 68.6 µM 2.95199940556129 0.00638239650709165 no 130 0.00157861769334125 81 675225
SGTC_1322 1348-1070 12 µM 2.94965424325736 0.0064178678466597 no 131 0.00159064865722867 33 6758089
SGTC_2993 9054257 71.4286 µM 2.94014028313814 0.00656356524408948 no 132 0.00164031839961638 110 6470217 YGL055W OLE1
SGTC_582 0987-0078 156 µM 2.93803748516719 0.00659615957669989 no 133 0.0016514854246656 148 1625765
SGTC_1859 st055998 20 µM 2.93012035641743 0.00672016609634724 no 134 0.00169415369964651 62 676301
SGTC_3117 9124945 49.47 µM 2.92306232428511 0.00683244888343263 no 135 0.00173303565572783 33 17592065
SGTC_1212 0520-0165 585 µM 2.91434195410336 0.00697346326651157 no 136 0.00178219619083304 95 5403258
SGTC_2910 7948405 25.97 µM 2.91273757501644 0.00699968519122553 no 137 0.00179137775325954 64 2971328
SGTC_13 0199-0087 65 µM 2.91188553230887 0.00701364630539004 no 138 0.0017962713083521 47 4589825
SGTC_2932 9016711 44.54 µM 2.90750340464437 0.00708583845282429 no 139 0.00182163189201537 107 7117328
SGTC_3131 9127911 49.47 µM 2.90542243407956 0.00712034985806368 no 140 0.00183378869757501 74 45595681
SGTC_2870 9038528 12.99 µM 2.89413044571676 0.00731021717709641 no 141 0.00190105086200497 70 6463316
SGTC_1811 st050069 61.5 µM 2.89269238933042 0.00733471474535608 no 142 0.00190977588440677 26 3877702
SGTC_1625 st003711 30.1 µM 2.88097892321272 0.00753696594661914 no 143 0.00198221074973465 98 24207034 YER133W GLC7
SGTC_683 panaxydol 45 µM 2.87216700421162 0.00769233913679863 no 144 0.00203833733053481 82 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_871 0574-0004 149 µM 2.84745735958755 0.00814315931950881 no 145 0.00220349987995372 116 9551173
SGTC_1180 1193-0155 285 µM 2.83914872267092 0.00829987966305757 no 146 0.00226170344438245 64 2921347
SGTC_565 1418-0001 44.5 µM 2.83058369235186 0.00846420273388944 no 147 0.00232315767733016 88 2862145
SGTC_2695 st077686 51.995 µM 2.82654333215258 0.00854270471370441 no 148 0.00235266886936545 89 2876092
SGTC_373 0844-0104 25.9 µM 2.81023095760442 0.00886617770775517 no 149 0.00247529800839254 130 5375804
SGTC_207 4185-0010 4.486 µM 2.80507401601751 0.00897064856309346 no 150 0.00251525133017739 168 3761753
SGTC_1971 st069429 63.5 µM 2.73352068598296 0.0105354176453098 no 151 0.00313305935841727 70 1246522 YGL099W LSG1
SGTC_1170 0310-0127 64.8 µM 2.72267228555753 0.0107923205878632 no 152 0.00323781294129489 100 774975
SGTC_466 geldanamycin 89.2 µM 2.72208069716464 0.0108064855767982 no 153 0.00324361495931021 46 5288382 HSP90 inhibitor.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.71213026457818 0.0110471755320513 no 154 0.00334261576675359 94 688667
SGTC_1354 1498-1681 81 µM 2.70844328297555 0.0111375362776187 no 155 0.00337998326409029 94 5754243
SGTC_805 3852-0218 479 µM 2.70375916074629 0.01125326142604 no 156 0.00342799805729853 144 6615355
SGTC_2040 5100729 123 µM 2.68549779224502 0.0117144608805836 no 157 0.00362109266100781 101 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_442 cape 100 µM 2.67566158641015 0.0119696115542374 no 158 0.00372909555213863 65 5281787
SGTC_1323 1348-1351 11.2 µM 2.67483536417647 0.0119912615114103 no 159 0.00373829780403097 67 6989654
SGTC_3249 9135183 49.47 µM 2.66991425066803 0.0121209169623787 no 160 0.00379353100366023 85 4902779
SGTC_810 3825-7150 143 µM 2.66688270113744 0.012201391960937 no 161 0.00382791935081092 63 22330411 YGL099W LSG1
SGTC_733 4069-0007 56.1 µM 2.66446112561392 0.0122660069652771 no 162 0.00385558892027093 192 5717425 YNL287W SEC21
SGTC_2422 chlorphenesin carbamate 384.24 µM 2.62374497201529 0.0133976760459794 no 163 0.00434844389656674 142 2724 A muscle relaxant with antifungal properties.
SGTC_676 falcarinol 140 µM 2.61832342483525 0.0135549638327235 no 164 0.00441815049847869 131 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_283 0987-0079 11.7 µM 2.61732361991143 0.0135841431800362 no 165 0.0044311137934109 122 411556
SGTC_2617 dihydrotanshinone i 20.83 µM 2.58740260150796 0.0144828283098532 no 166 0.00483512651189921 136 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2127 5253358 187.912 µM 2.58558420981537 0.014539056620773 no 167 0.0048607061304991 106 20612
SGTC_2807 7945238 51.95 µM 2.58258855792905 0.0146320979051033 no 168 0.00490310957152021 136 17148797
SGTC_333 3486-0131 40.1 µM 2.58245292921984 0.0146363224620429 no 169 0.00490503717179543 77 6744690
SGTC_278 4092-0821 23.9 µM 2.57764809307193 0.0147866619278396 no 170 0.00497376229375027 120 877900
SGTC_2694 st077685 81.9 µM 2.54658993602792 0.0157908460756948 no 171 0.00543905883668138 128 2838096
SGTC_1645 Cervolide 78 µM 2.5426606318272 0.0159219652398142 no 172 0.00550060107322817 69 23173 A fragrance.
SGTC_976 1348-1067 47.6 µM 2.53155993487986 0.0162974452702727 no 173 0.00567782042843187 132 5310671 YGL099W LSG1
SGTC_1295 1013-0063 9.78 µM 2.52478740497637 0.01653023033613 no 174 0.00578841496697903 107 6826038
SGTC_2717 st081029 62.2815 µM 2.51011754065486 0.0170442370636286 no 175 0.00603454905802966 78 5292846
SGTC_559 1550-0661 158 µM 2.50961619165097 0.0170620422425919 no 176 0.00604312231884828 87 5830875
SGTC_1034 k072-0165 12.7 µM 2.50226329133761 0.0173250090231301 no 177 0.0061701057330755 120 5835461
SGTC_1404 3909-7820 48.3 µM 2.50088744830994 0.0173745967999097 no 178 0.0061941271102452 86 23741373
SGTC_2502 avocadyne acetate 18.59 µM 2.50032868258919 0.0173947702715262 no 179 0.00620390644506829 147 3952079
SGTC_3303 9125618 40.5795 µM 2.50000566943612 0.0174064413408363 no 180 0.00620956595090048 178 22695467
SGTC_679 0422-0091 41.4 µM 2.48734725440068 0.0178691087474378 no 181 0.00643498534743819 144 627384 YHR062C RPP1
SGTC_439 amiodarone 34.4 µM 2.48268768977407 0.0180420380140528 no 182 0.00651976770939052 213 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_142 0335-0849 62.6745 µM 2.48170386293142 0.018078732399778 no 183 0.00653779458344538 269 3889043 YPR107C YTH1
SGTC_1637 st007924 17.4 µM 2.481269307087 0.0180949605376207 no 184 0.0065457710708025 117 683336
SGTC_872 0588-0139 234 µM 2.47574153518976 0.0183024766923741 no 185 0.0066479896603297 146 2047100
SGTC_1075 aripiprazole 15.2 µM 2.47316440859379 0.0183999145952961 no 186 0.00669612585895265 155 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2724 maprotiline 69.64 µM 2.46629786829785 0.0186616892405625 no 187 0.00682588775464535 97 4011 A tricyclic antidepressant.
SGTC_2744 captopril 92.04 µM 2.46235780530106 0.0188133236183077 no 188 0.00690134459906371 58 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1728 st035614 33.7865 µM 2.44611844424816 0.0194494122438437 no 189 0.00722017762772047 192 15945546
SGTC_2996 9066192 71.4286 µM 2.44481350956949 0.0195013097722064 no 190 0.00724635297860233 159 6472854
SGTC_1335 1486-0900 202 µM 2.44310000382293 0.0195696348493138 no 191 0.00728085080971891 140 X1335
SGTC_3259 9138485 49.47 µM 2.44231796439055 0.0196008857332168 no 192 0.0072966435943555 116 17646153
SGTC_905 2-aminofluorene 215 µM 2.42798354069727 0.0201812506274478 no 193 0.0075915161519008 141 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2356 9061756 188.97 µM 2.42579384910531 0.0202711761877982 no 194 0.00763747213559915 87 20104043
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.42216823983744 0.0204208184085907 no 195 0.00771410298369523 121 688662
SGTC_1232 0279-0259 161 µM 2.40955223110765 0.0209488442575824 no 196 0.00798605483197702 134 1560000
SGTC_2921 7974240 10.71 µM 2.40098208297908 0.0213140898020672 no 197 0.00817556853982581 176 2979074 YDR527W RBA50
SGTC_3183 9108214 49.47 µM 2.39952041001056 0.0213769183474796 no 198 0.00820828230017037 35 4974831
SGTC_2743 auranofin 4.32 µM 2.39678617755786 0.0214948670481192 no 199 0.00826978612548636 133 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.37773864674694 0.0223318926706639 no 200 0.00870958360329719 187 688788
SGTC_2205 7238770 200 µM 2.37049167756123 0.0226574951052318 no 201 0.00888222193327303 89 279867
SGTC_2081 5214970 32.255 µM 2.36769160817311 0.0227843680416078 no 202 0.00894972444748889 126 2063512
SGTC_3017 9080681 49.47 µM 2.3474211238079 0.0237208062915634 no 203 0.00945193759478855 132 16451914
SGTC_704 1310-0270 142 µM 2.34150190978844 0.0240002861887911 no 204 0.00960316384804574 161 5718033
SGTC_2096 5468907 200 µM 2.32765251329892 0.0246650209835489 no 205 0.00996528129189348 115 759785
SGTC_2477 5967686 25.23 µM 2.32149684313429 0.0249653983582512 no 206 0.0101300221390975 142 776118
SGTC_1723 st034307 2.5525 µM 2.31563419711717 0.0252543227113631 no 207 0.0102891250159434 154 867466
SGTC_301 4119-0100 24.5 µM 2.30974951509822 0.0255471453106261 no 208 0.0104510128829161 215 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2745 rifampicin 24.3 µM 2.30224798810499 0.0259245392809441 no 209 0.0106605955695325 58 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_65 0798-0905 34.986 µM 2.30223512716608 0.02592519028488 no 210 0.0106609580075151 291 3602145
SGTC_1518 st038567 90.8 µM 2.29985374156383 0.0260459688680003 no 211 0.0107282537868332 120 77966
SGTC_486 niguldipine 82 µM 2.28587864038598 0.0267642766032826 no 212 0.0111306796798179 111 1236 A calcium channel blocker.
SGTC_706 4262-0057 46.9 µM 2.27713241184068 0.0272221859080871 no 213 0.0113891598553421 174 883298
SGTC_1720 st037298 9.481 µM 2.27444096693224 0.0273644048833325 no 214 0.0114697433356442 168 597396
SGTC_836 0330-0104 1.35 µM 2.27418980535994 0.0273777080959999 no 215 0.0114772884683926 139 46494820
SGTC_1885 st057546 99.9 µM 2.27159750316748 0.0275153292985798 no 216 0.0115554159200493 168 702008
SGTC_2101 5377231 179.231 µM 2.27131521071512 0.0275303505179577 no 217 0.0115639515408421 116 2844213
SGTC_2444 5485484 36.41 µM 2.27087532192123 0.0275537713095227 no 218 0.011577263284132 183 6790631
SGTC_3041 9091929 49.47 µM 2.26471813908905 0.0278833422848354 no 219 0.0117649908182557 159 25236887
SGTC_2581 avocatin a 64 µM 2.25296535616404 0.0285215428184663 no 220 0.0121306667075773 201 6710728 A skin care supplement.
SGTC_2649 anisomycin 9.56 µM 2.25231620095878 0.0285571445541536 no 221 0.0121511485371964 87 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1209 2323-2347 50.3 µM 2.25100660933316 0.0286290792362291 no 222 0.012192559384031 125 5412760
SGTC_1421 4029-0249 71.4 µM 2.246820747601 0.0288600161885785 no 223 0.0123257426253061 171 2894095
SGTC_1922 5578187 25 µM 2.24210779025542 0.0291218845502297 no 224 0.0124772033203837 187 1350412
SGTC_3095 9117207 49.47 µM 2.24122726324391 0.0291710279142878 no 225 0.0125056788626151 99 17015229
SGTC_735 3076-0345 636 µM 2.23909866619734 0.0292901123189613 no 226 0.0125747485218359 189 2888990
SGTC_2024 5144227 134 µM 2.22719228647524 0.0299636827956195 no 227 0.0129672127142845 186 3475211
SGTC_1042 0350-0096 82 µM 2.22637593910057 0.0300103321639266 no 228 0.0129945053743195 163 3122515
SGTC_800 3448-7362 155 µM 2.22277037354881 0.0302170896348387 no 229 0.0131156438912682 445 15991913
SGTC_3082 9117008 49.47 µM 2.22154076636944 0.0302878696271187 no 230 0.0131571783767368 147 41448529
SGTC_1934 st074720 32.6 µM 2.21615972495054 0.0305992372461659 no 231 0.0133402825421028 226 17250992
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.21002226685943 0.0309576054380699 no 232 0.0135518084845016 241 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2650 prasterone 100 µM 2.20023742458212 0.0315361239272792 no 233 0.0138950271725025 83 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1346 1488-2224 62.4 µM 2.19422415728445 0.0318960648517425 no 234 0.0141096493531531 139 3722427
SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.19413398297565 0.0319014882033448 no 235 0.0141128894237992 165 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2341 7987486 176.74 µM 2.19235494662344 0.0320086405810866 no 236 0.0141769435501144 191 1258686
SGTC_422 cantharidin 155 µM 2.19030879732114 0.0321322486286747 no 237 0.0142509246282841 243 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3304 9125678 46.087 µM 2.18995814658088 0.0321534709697432 no 238 0.0142636361634227 205 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_849 0386-0493 241 µM 2.17417879414038 0.0331205229835334 no 239 0.0148458551490803 159 726119
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.17238298620898 0.0332320838094933 no 240 0.0149133936185765 175 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2140 5586273 200 µM 2.16433342453172 0.0337359554929935 no 241 0.01521938462977 121 854421
SGTC_2232 chlorophetanol 41.5365 µM 2.16095667913413 0.0339491902973776 no 242 0.0153493429815388 311 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3292 9120825 59.784 µM 2.15317419150384 0.0344448624694863 no 243 0.0156524955945934 170 24824900
SGTC_731 3966-0296 387 µM 2.14482579736133 0.0349831723307028 no 244 0.0159833888946193 168 660956
SGTC_369 0957-0393 4.5 µM 2.14340085640863 0.035075739687092 no 245 0.0160404621969255 179 6997992
SGTC_1428 4049-0204 61.7 µM 2.13648351755135 0.0355279658571356 no 246 0.0163200115176782 172 X1428
SGTC_1473 k844-0725 134 µM 2.13179200547614 0.0358373889154172 no 247 0.0165119745757538 192 54682906
SGTC_832 4083-0019 164 µM 2.12013241404645 0.0366159540090314 no 248 0.0169974400464077 374 1990758
SGTC_1624 st003710 6.25 µM 2.10889816179085 0.0373791528479351 no 249 0.0174766864590237 238 24207033
SGTC_1005 4092-0690 4.4 µM 2.10752579533776 0.0374732687790378 no 250 0.0175360140651221 185 1529343
SGTC_3162 9099653 49.47 µM 2.08704913385188 0.0389006692631885 no 251 0.0184418466810144 132 25237511
SGTC_161 4065-0411 162.148 µM 2.08631533067874 0.0389526323654279 no 252 0.018475034436891 272 1906281 YLR208W SEC13
SGTC_3240 9133527 49.47 µM 2.0848727902366 0.0390549483368309 no 253 0.0185404245779557 163 17617455
SGTC_1622 st003707 19.4 µM 2.07822610527243 0.0395292121074609 no 254 0.0188442693819205 255 10140899
SGTC_2123 5259487 200 µM 2.07667871118924 0.0396402935551458 no 255 0.0189156113738923 203 2173474
SGTC_84 0443-0269 128.823 µM 2.07341002171647 0.0398757746382413 no 256 0.0190670685301249 209 6150058
SGTC_405 ebelactone b 50 µM 2.07001578508688 0.0401215024137064 no 257 0.0192254331402263 191 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_14 0354-0009 295 µM 2.04837037933407 0.0417176131021649 no 258 0.0202618608148179 206 1713507
SGTC_816 0325-0417 81.3 µM 2.04723830305589 0.0418024866001119 no 259 0.0203173461617948 179 68101
SGTC_895 0964-0006 13.7 µM 2.04672017403179 0.0418413781462363 no 260 0.0203427836447591 193 6738897
SGTC_2489 cantharidin 73.42 µM 2.04444821800589 0.0420122606405568 no 261 0.0204546439955124 260 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_315 k915-0449 187 µM 2.03553584188477 0.0426880565754627 no 262 0.0208984929687966 284 20970215 YNL149C PGA2
SGTC_955 1216-0110 33 µM 2.03355063143547 0.0428397789852322 no 263 0.0209984618649054 298 3619719
SGTC_3334 9142812 21.919 µM 2.03004101848646 0.0431090720226757 no 264 0.0211761850099499 214 45283678
SGTC_1825 st052143 62.6 µM 2.0290236976294 0.0431873862974613 no 265 0.0212279383330744 169 674173
SGTC_562 3772-2733 112 µM 2.0247324009396 0.043518999685554 no 266 0.0214474248410083 283 2876874 YIL048W NEO1
SGTC_1240 0356-0016 42.1 µM 2.02402589677239 0.0435737918845157 no 267 0.0214837436282613 226 4305613
SGTC_80 0159-0065 512.242 µM 2.02220082305117 0.0437155912948411 no 268 0.0215778046484798 109 1548079
SGTC_888 0916-0002 6.97 µM 2.0184619936278 0.0440072428737163 no 269 0.0217715842841841 205 2802138 YIL048W NEO1
SGTC_2765 myclobutanil 7.74 µM 2.0155983213233 0.0442316863274111 no 270 0.0219209977333559 236 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2959 9079155 11 µM 2.01432950727376 0.0443314255581514 no 271 0.0219874749849611 199 16189457
SGTC_1489 4065-0444 182 µM 2.01252565973791 0.0444735347543309 no 272 0.0220822772921482 198 2877968
SGTC_256 clotrimazole 625 nM 2.01202075233053 0.0445133776213437 no 273 0.0221088747284642 243 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3347 9188721 44.724 µM 2.01090132907264 0.044601815248227 no 274 0.0221679399775806 181 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_637 1181-0519 7.26 µM 2.01002871140344 0.0446708526484757 no 275 0.0222140750879758 338 6252091 YGR060W ERG25
SGTC_346 4513-0042 7.16 µM 2.00540839876624 0.0450378254969906 no 276 0.0224597022824123 246 2827372
SGTC_1797 st048695 56.8 µM 2.00262698729973 0.0452599092550413 no 277 0.0226086704706844 234 592262 YIL048W NEO1
SGTC_2225 6654152 15.4 µM 2.00065851216166 0.0454176152862914 no 278 0.0227146016449518 143 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_935 2996-0153 430 µM 1.99652230815623 0.045750430673414 no 279 0.022938550013293 197 23738523
SGTC_3198 9112019 49.47 µM 1.9947549656125 0.0458932345058701 no 280 0.0230348056351233 198 45595555
SGTC_227 fluconazole 33.516 µM 1.993100777012 0.0460272196334832 no 281 0.0231252064719295 297 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1800 st050079 29.0735 µM 1.99200420793731 0.0461162120499348 no 282 0.0231852980956504 432 3645560
SGTC_3214 9129694 49.47 µM 1.98844043561422 0.0464063859196475 no 283 0.0233815002432022 232 17158655
SGTC_321 4534-3890 65.3 µM 1.98459111638188 0.0467214546310248 no 284 0.0235949907592789 171 699746
SGTC_2325 6158266 200 µM 1.98334783860293 0.0468235834301718 no 285 0.0236642946295881 226 3623240
SGTC_2021 4019055 173 µM 1.98298096160193 0.0468537546603027 no 286 0.0236847780870858 408 44827708 YER133W GLC7
SGTC_1055 3448-0672 86 µM 1.98174807449343 0.0469552590928296 no 287 0.0237537218437727 223 748378
SGTC_780 0109-0199 192 µM 1.9817080311812 0.0469585588403996 no 288 0.0237559639150216 258 610414
SGTC_972 1319-0219 195 µM 1.98005703574197 0.0470947701987495 no 289 0.0238485600752591 221 23903702
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.97633909660168 0.0474026696395524 no 290 0.0240581921878065 199 2346 DNA damaging agent; causes G2/M arrest.
SGTC_375 3970-0961 9.27 µM 1.97409371269812 0.047589399941385 no 291 0.0241855440651712 235 2898222
SGTC_2084 5306078 60.6385 µM 1.9644627900589 0.048397018245835 no 292 0.0247382236843461 230 679340
SGTC_383 2324-0395 7.37 µM 1.9617852058498 0.0486234887180518 no 293 0.0248937483990695 249 3146421
SGTC_789 1309-1135 70.6 µM 1.96101848592557 0.0486884938037844 no 294 0.0249384332488563 245 3092424
SGTC_812 4251-0442 148 µM 1.95643186173071 0.049078815217375 no 295 0.025207150942589 187 5723007
SGTC_581 0958-0271 211 µM 1.95449766608841 0.0492441626081398 no 296 0.0253211953049064 317 4591145
SGTC_367 0335-0881 7.1 µM 1.95410237525053 0.0492780092751594 no 297 0.0253445556280757 294 23828853
SGTC_1884 5633444 25 µM 1.94957618226923 0.04966688876466 no 298 0.0256133272537264 284 5724239
SGTC_2409 alverine citrate 63.97 µM 1.94565958763794 0.0500053657507984 no 299 0.0258478220455466 277 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_960 1222-0186 7.7 µM 1.94185040172367 0.0503363222793407 no 300 0.0260776066071434 257 3126296
SGTC_2721 ifenprodil 61.44 µM 1.93418674868484 0.0510074571290826 no 301 0.0265450855281968 233 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1497 4476-2978 41.3 µM 1.93128015018746 0.0512638541877867 no 302 0.0267242083832779 278 1528379
SGTC_3148 9097893 49.47 µM 1.92964996858913 0.0514081040533322 no 303 0.0268251114977266 255 17174100
SGTC_1064 honokiol 6.76 µM 1.92504121045512 0.0518176662066727 no 304 0.027112101411951 249 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_834 0312-0008 75.7 µM 1.92266042123386 0.0520302510796622 no 305 0.0272613552460733 298 6385573 YIL048W NEO1
SGTC_3137 9097352 49.47 µM 1.92058431982153 0.0522161948579532 no 306 0.0273920667684716 297 44120435
SGTC_1694 st024011 44.9 µM 1.90895222425661 0.0532677920807587 no 307 0.0281341275431302 268 2787533
SGTC_2764 methyldopa 94.69 µM 1.90867957758081 0.0532926405304904 no 308 0.0281517196289625 261 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_550 4123-0385 25.7 µM 1.90724867668551 0.053423200528398 no 309 0.0282441964156631 243 5731123
SGTC_1013 4112-3890 241 µM 1.90692672524471 0.0534526113150048 no 310 0.0282650384214207 262 705171
SGTC_2707 st078556 66.6 µM 1.9002275943839 0.0540675035870101 no 311 0.0287016292536323 210 17250899
SGTC_3295 9122362 53.5725 µM 1.89434576334603 0.0546119821923576 no 312 0.0290895651990084 223 4730473
SGTC_634 1611-4317 11.2 µM 1.89340327764844 0.0546996293296446 no 313 0.0291521299450421 270 2843522
SGTC_1634 st006576 41 µM 1.88643152849423 0.0553514306712573 no 314 0.0296184136262945 255 3915356
SGTC_3281 9140613 49.47 µM 1.88548844556357 0.0554400701905051 no 315 0.0296819614815042 220 16013766
SGTC_516 3992-2719 87.3 µM 1.88329890085661 0.0556462956875502 no 316 0.029829936153413 233 5350887 YDR037W KRS1
SGTC_2218 6965428 192.983 µM 1.88162853833679 0.055804027993573 no 317 0.0299432343096139 216 675684
SGTC_994 3910-0338 138 µM 1.87811896082236 0.056136586505038 no 318 0.0301824465165267 293 3479481
SGTC_351 caspofungin 25 nM 1.87728948921704 0.0562154129713883 no 319 0.0302392140085774 397 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1160 4092-0570 10.5 µM 1.87554246690141 0.0563817217076261 no 320 0.0303590664594013 290 4994975
SGTC_3060 1327-0027 12.5 µM 1.87092084930233 0.0568235493110038 no 321 0.0306780263403226 244 16000455 YPR107C YTH1
SGTC_2285 7945142 200 µM 1.87088631130363 0.0568268613865413 no 322 0.0306804203783535 258 2970608
SGTC_2796 7949634 45.45 µM 1.87081131261981 0.0568340540264615 no 323 0.0306856195244151 263 2971588
SGTC_766 1391-0721 126 µM 1.86628325892195 0.0572696403839637 no 324 0.0310008728722982 258 1020919 YIL115C NUP159
SGTC_2864 9034755 47.6 µM 1.86255125672279 0.0576306200951835 no 325 0.0312627138068394 259 4930451
SGTC_1086 cerivastatin 2.18 µM 1.86015827375905 0.057863022464816 no 326 0.0314315682806907 206 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_830 4076-0286 57.8 µM 1.85639035336436 0.0582304489373437 no 327 0.0316989693636322 447 6866659
SGTC_544 k015-0020 52.4 µM 1.85445216933569 0.0584201623686362 no 328 0.031837248527249 256 3008304
SGTC_282 k297-0036 65.7 µM 1.84761524545623 0.0590932527902767 no 329 0.0323290113259034 217 5061378
SGTC_389 tpck 16.7 µM 1.84719875632871 0.0591344516092311 no 330 0.0323591697873151 258 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1994 st072947 40.9 µM 1.84701816744356 0.0591523223382791 no 331 0.0323722536515098 273 5286565 YDL195W SEC31
SGTC_1812 st052057 4.327 µM 1.84676849158528 0.0591770367573922 no 332 0.0323903501324732 275 3645418
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.84465686356549 0.0593863824082256 no 333 0.0325437347753306 300 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.84201100181408 0.0596495106958294 no 334 0.0327367703058078 283 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_946 3434-1334 87.4 µM 1.83254427966874 0.0605984545313244 no 335 0.0334351855061171 264 4047976
SGTC_646 4092-0839 27.3 µM 1.82966269112918 0.0608896373369429 no 336 0.0336501965279288 261 877796
SGTC_1917 st066507 28.5 µM 1.82864897035714 0.0609923329405184 no 337 0.033726105798143 338 3156428
SGTC_1730 st033808 45.1 µM 1.82819772680356 0.0610380899726746 no 338 0.0337599410339745 347 1045166
SGTC_2320 7373003 200 µM 1.82759803110842 0.0610989418802529 no 339 0.0338049507566424 268 5415828
SGTC_1179 1021-1431 9.29 µM 1.82735343793144 0.0611237746793727 no 340 0.033823322687827 350 2840958
SGTC_2491 paeonol 100 µM 1.82285256306275 0.0615821442390084 no 341 0.0341628620986818 218 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1684 st024538 14.6195 µM 1.82076293550092 0.0617958624775461 no 342 0.0343214503580903 277 6732859
SGTC_884 0851-0618 334 µM 1.81906459795491 0.0619699873734996 no 343 0.0344507876713318 297 9642473
SGTC_599 1935-0052 86.5 µM 1.8138419167662 0.0625078512061317 no 344 0.0348510335475539 298 9557311
SGTC_883 0850-0245 24.6 µM 1.81116477625578 0.0627849670021986 no 345 0.0350576744443789 310 6823229 YPR165W RHO1
SGTC_3202 9113761 49.47 µM 1.81026789427475 0.0628780187039344 no 346 0.035127126662176 362 4798415
SGTC_2242 6630449 61.2675 µM 1.80744970775359 0.0631711055173931 no 347 0.0353460947534172 266 691249 YDR170C SEC7
SGTC_911 3456-4043 236 µM 1.80570293561083 0.0633533003259067 no 348 0.0354823769383667 320 914281
SGTC_2703 st077852 53.4 µM 1.8055287367183 0.0633714923242338 no 349 0.0354959914315787 283 6281836
SGTC_3299 9121982 43.1275 µM 1.80490469021168 0.0634366963407752 no 350 0.0355447988690088 290 17594604 YPL160W CDC60
SGTC_529 4076-0302 30.3 µM 1.80408348825852 0.0635225798639877 no 351 0.0356091098976273 285 5816522
SGTC_939 1165-0479 45.3 µM 1.79513646654932 0.0644641568167492 no 352 0.0363159799756978 307 1377347
SGTC_133 0724-0033 378.92 µM 1.792611248478 0.064731861252373 no 353 0.0365175532683773 260 280309
SGTC_921 1561-0023 372 µM 1.79199065608166 0.0647977837144007 no 354 0.0365672313911411 290 24050882
SGTC_2916 7875993 68.79 µM 1.78810914761056 0.0652112804458448 no 355 0.036879200029059 304 1299250
SGTC_1176 0848-0131 83.3 µM 1.78273978828415 0.0657866491006952 no 356 0.0373143356278003 315 6769040
SGTC_2289 7946404 165.07 µM 1.78218048918054 0.0658468079375679 no 357 0.0373599017187878 403 1246120 YPR165W RHO1
SGTC_1562 morin hydrate 59.1 µM 1.78094359369188 0.0659800012006016 no 358 0.0374608329930844 284 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_745 0469-0705 296 µM 1.7768971177107 0.0664171989037802 no 359 0.0377925843557831 334 3486736
SGTC_687 k029-0044 34.9 µM 1.7708254718553 0.067077407649423 no 360 0.0382948643947085 282 5829338
SGTC_1820 st053765 18.6 µM 1.77060815937643 0.0671011311576731 no 361 0.0383129420879921 283 3690829
SGTC_1944 st076371 56.9 µM 1.76392971709547 0.0678333697153025 no 362 0.0388719064457741 307 24208455
SGTC_2952 9073731 13.78 µM 1.76347610277233 0.0678833278963056 no 363 0.0389101121502445 352 16457353
SGTC_218 alverine citrate 93.75 µM 1.75652340203573 0.0686526139867163 no 364 0.0394995395670777 261 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2416 tofa 880 nM 1.75355811273425 0.0689827484496633 no 365 0.0397531268506617 324 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_475 α-linolenic acid 10 µM 1.75275414483081 0.0690724671016704 no 366 0.0398221086480607 322 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1687 st020778 55.3625 µM 1.75148235324744 0.0692145760569553 no 367 0.0399314291888525 486 4259299
SGTC_1107 amlodipine 47 µM 1.74988087719916 0.0693938439795599 no 368 0.0400694355309934 318 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_357 1325-0123 420 µM 1.74449737084911 0.0699990916395096 no 369 0.0405361997317936 268 1098503
SGTC_1164 k060-0068 93.7 µM 1.74041148548797 0.0704611574544318 no 370 0.040893395100905 329 5963676
SGTC_625 k213-0058 121 µM 1.73109779122444 0.0715231885396383 no 371 0.0417171621290934 501 3655420
SGTC_1561 5-methoxyflavone 52.9 µM 1.72952712084222 0.0717034946256933 no 372 0.0418573984318056 217 94525
SGTC_3044 9093193 49.47 µM 1.72306526929097 0.0724489567380231 no 373 0.0424383612791668 356 25236277
SGTC_814 3342-0569 96 µM 1.7215721333827 0.0726220517326465 no 374 0.0425735274097369 344 4346283
SGTC_2129 girgensonine 121.053 µM 1.72152204081482 0.072627864307876 no 375 0.0425780680677202 353 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3272 9137413 49.47 µM 1.72146728179764 0.0726342187700187 no 376 0.0425830321656 290 17614870
SGTC_775 4577-0580 57.3 µM 1.71796124288994 0.0730419610148389 no 377 0.0429018424034699 298 2006902
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.71584008122266 0.0732894951443923 no 378 0.0430956579787666 271 17037758
SGTC_2794 7785382 27.27 µM 1.71508810636515 0.0733774025900446 no 379 0.0431645372908745 409 2205081
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.70865160699783 0.0741331454699352 no 380 0.0437577515756712 427 6708739 YPR165W RHO1
SGTC_2882 9058044 58.44 µM 1.70621401314167 0.0744209032017797 no 381 0.0439841203123134 292 18076804
SGTC_2347 9049783 174.81 µM 1.69756913035621 0.0754483085714034 no 382 0.044794556617058 372 6467988 YPL169C MEX67
SGTC_1374 2889-5571 141 µM 1.69670798207777 0.0755512412943072 no 383 0.0448759414226041 369 2853281
SGTC_1130 3454-2858 15.9 µM 1.69611829744183 0.0756217877718564 no 384 0.0449317395663291 371 715628 YIL048W NEO1
SGTC_1067 clotrimazole 1.36 µM 1.69354911920856 0.0759297352507744 no 385 0.0451754967803696 358 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3283 9109332 35.8195 µM 1.69175321806822 0.0761455623999831 no 386 0.0453465183917883 250 17027281
SGTC_3238 9133470 49.47 µM 1.68832910421408 0.0765583577946822 no 387 0.0456740356658585 275 3534688
SGTC_3324 9138759 60.749 µM 1.68012490461684 0.0775543412057808 no 388 0.0464665081339681 323 45595710
SGTC_1369 1866-0067 208 µM 1.677480922331 0.0778774059907308 no 389 0.0467242384847844 388 3531355
SGTC_2815 7968870 71.43 µM 1.67714960517194 0.077917961109378 no 390 0.0467566153564095 376 2977326 YHR190W ERG9
SGTC_1106 tegaserod maleate 11.7 µM 1.6752582913215 0.0781497756797536 no 391 0.0469417825051672 365 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2011 4012611 177 µM 1.67016954097821 0.078776090811304 no 392 0.0474429122560704 348 2049887
SGTC_2038 4100038 30.985 µM 1.66594798478189 0.0792985533208825 no 393 0.0478618875182766 366 3596803
SGTC_981 1488-1094 54.9 µM 1.665096716471 0.0794042239202426 no 394 0.0479467308617396 275 3449522
SGTC_1495 4469-0029 237 µM 1.66148464758199 0.0798537871465722 no 395 0.048308074881288 487 793680
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.66034158852422 0.079996454127871 no 396 0.0484228768578556 318 2724278 An inhibitor of dopamine biosynthesis.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.6585442180892 0.0802211763835242 no 397 0.0486038351065628 350 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2255 7941087 197.44 µM 1.65814565217207 0.0802710729914627 no 398 0.04864403564599 389 935561
SGTC_1498 4478-3555 97.6 µM 1.65678885121626 0.0804411072122197 no 399 0.0487810859067059 259 3437919
SGTC_31 0508-1974 57.237 µM 1.65546135530012 0.0806077321543115 no 400 0.0489154745725079 325 6810525
SGTC_136 0097-0015 404.482 µM 1.65368476167061 0.0808311347686405 no 401 0.0490957902017191 373 4861337
SGTC_294 k038-0071 157 µM 1.65266199711869 0.0809599569337365 no 402 0.0491998364001406 386 24152826
SGTC_542 3381-0244 89.3 µM 1.65075246528001 0.081200886425995 no 403 0.0493945649858598 392 1112843
SGTC_1006 4099-6547 255 µM 1.6504130394837 0.0812437690333468 no 404 0.0494292429733503 346 3146833
SGTC_2212 7123476 200 µM 1.64409703724061 0.082044844569423 no 405 0.0500780799312371 240 1085715
SGTC_2840 9008771 71.43 µM 1.6424722508485 0.0822518797677767 no 406 0.0502460861639632 280 2992978
SGTC_2754 granisetron 64.02 µM 1.63660969554303 0.0830021760540354 no 407 0.0508560242351286 382 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2665 lovastatin 100 µM 1.63438277679019 0.0832885247417813 no 408 0.0510892511882974 324 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_54 0159-0055 9 µM 1.63428059486909 0.0833016816179265 no 409 0.051099973172186 349 3319099
SGTC_2329 6138490 200 µM 1.63099197897581 0.0837259564072395 no 410 0.051446006000034 323 720019
SGTC_1361 1608-0041 5.61 µM 1.62730914658011 0.0842030148986586 no 411 0.0518357281430356 363 X1361
SGTC_1801 st050089 28.441 µM 1.62333222184579 0.0847204569017216 no 412 0.0522592025182827 486 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1791 st048313 56.1 µM 1.6194256684105 0.0852310608795869 no 413 0.0526778538587863 311 1204976
SGTC_1169 aniline yellow 25.8 µM 1.61073901455008 0.0863747037394272 no 414 0.0536183091655362 316 6051 A DNA damaging agent.
SGTC_1096 rimcazole 32.2 µM 1.60436515475985 0.087221126650753 no 415 0.0543167935297516 320 18528119 A dopamine reuptake inhibitor.
SGTC_462 ag-879 158 µM 1.60342136031525 0.0873469833712546 no 416 0.054420829127586 399 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3236 9132701 49.47 µM 1.60221577452464 0.0875079475774811 no 417 0.0545539514925896 345 24282524
SGTC_1020 4335-0961 93.3 µM 1.60168235090724 0.0875792384192683 no 418 0.0546129349471527 353 669075
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.5981337483213 0.0880546045094303 no 419 0.0550066071414228 409 165506
SGTC_465 cgp-37157 41 µM 1.59809107300636 0.0880603329214966 no 420 0.0550113550322212 238 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_548 1436-0017 110 µM 1.59785547249096 0.0880919631571723 no 421 0.0550375728649968 442 9677137
SGTC_384 k007-0144 5.16 µM 1.59679245098167 0.0882347830362193 no 422 0.0551559896210464 437 6824886
SGTC_404 fumagillin 50 µM 1.58992662048043 0.0891613858825644 no 423 0.0559256731824684 401 12015870 A methionine aminopeptidase binder.
SGTC_3185 9108267 49.47 µM 1.5896444281872 0.0891996244985899 no 424 0.0559574882880286 386 4910486
SGTC_366 0181-0206 4.31 µM 1.58695962429925 0.0895640407904345 no 425 0.0562608947075338 417 274874
SGTC_66 0109-0187 42.4 µM 1.58557068419614 0.0897529996731409 no 426 0.0564183653806357 386 759417
SGTC_1556 plumbagin 1.48 µM 1.58510932470348 0.0898158310241769 no 427 0.0564707486663225 308 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2369 9071472 200 µM 1.58176471121644 0.0902723031773473 no 428 0.0568516468827048 388 17296037
SGTC_2777 climbazole 1.536 µM 1.57281982411761 0.0915015624785432 no 429 0.057880272000337 417 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2126 5251174 33.877 µM 1.56916063143328 0.0920079903634471 no 430 0.0583052574626138 468 790722
SGTC_418 lividomycin a 100 µM 1.56833960861105 0.0921219034851973 no 431 0.0584009484334567 377 72394 An antibiotic.
SGTC_2147 5545932 89.7195 µM 1.56778841326693 0.0921984378487353 no 432 0.0584652599284746 358 797404
SGTC_2461 5755302 26.15 µM 1.55782013104728 0.0935906829989715 no 433 0.0596379462474785 431 2788904
SGTC_2493 resveratrol 26.09 µM 1.55744014826118 0.0936440597570087 no 434 0.0596830101528336 323 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2890 9046729 58.44 µM 1.55386188501675 0.0941478066786949 no 435 0.0601086825441884 347 903329
SGTC_730 1436-0052 41.2 µM 1.55028254826416 0.0946537019463557 no 436 0.0605368570916695 333 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_722 3534-0461 190 µM 1.54780114722337 0.0950055916510937 no 437 0.0608350901089905 409 658262
SGTC_1685 st024049 53.0905 µM 1.54734168691551 0.0950708537288017 no 438 0.060890437271344 348 1941139
SGTC_2435 5706476 10.6 µM 1.54454806732296 0.0954683723562522 no 439 0.0612278080355884 429 5725375
SGTC_2183 6420625 130.508 µM 1.54202391388919 0.0958285981187106 no 440 0.0615338912541132 473 2897619
SGTC_146 3448-8650 53.125 µM 1.54182658654965 0.0958568010809994 no 441 0.0615578697806501 568 2891488 YIL048W NEO1
SGTC_2663 amphotericin b 100 µM 1.53994257006994 0.0961263811483922 no 442 0.0617871764397663 376 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_593 1203-0218 61.7 µM 1.53399574853858 0.0969809555320781 no 443 0.0625153493508425 383 3666956
SGTC_1992 st073643 23.3 µM 1.52280406296966 0.098604331545391 no 444 0.0639038665936201 389 3161292
SGTC_2918 7977171 22.06 µM 1.51937571234584 0.0991055784192201 no 445 0.0643339759286208 387 2236483
SGTC_865 0488-0499 301 µM 1.51597612555057 0.0996044575192793 no 446 0.0647626947042709 439 9634651
SGTC_3269 9137823 49.47 µM 1.51560902904956 0.0996584374045794 no 447 0.0648091213086158 371 17682936
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.50980314837898 0.100515010105931 no 448 0.0655468307324118 445 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_728 3030-5151 22.5 µM 1.50954876078788 0.100552663722838 no 449 0.06557930213493 377 3125388
SGTC_1089 terbinafine 2.25 µM 1.50870708327766 0.100677319413578 no 450 0.0656868272983349 402 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3187 9109394 49.47 µM 1.50805937086186 0.100773324841437 no 451 0.0657696662436036 443 17098090
SGTC_1653 st012112 65 µM 1.50654426115927 0.100998158598286 no 452 0.0659637568964149 387 720429
SGTC_2219 9098279 200 µM 1.50479088430265 0.101258806042085 no 453 0.0661889240540592 404 902349
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.50106521286123 0.101814270502231 no 454 0.066669347648195 318 77254
SGTC_1356 1502-0781 85.8 µM 1.50008169826779 0.10196127313043 no 455 0.0667966205539888 411 567702
SGTC_1370 2001-0092 44.6 µM 1.49501750991963 0.102720646012412 no 456 0.0674549362141608 500 790957
SGTC_3294 9122953 26.2835 µM 1.49289444710899 0.103040218187061 no 457 0.067732409458668 424 16459826
SGTC_1510 1123-0200 71.5 µM 1.49077418346126 0.10336008913597 no 458 0.0680103959739406 505 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_851 0394-0702 453 µM 1.48850783100582 0.103702796002145 no 459 0.0683085092492471 455 762646
SGTC_313 3474-0040 5.03 µM 1.48731600168011 0.103883349088542 no 460 0.0684656851016438 499 1043375 YIL048W NEO1
SGTC_1444 4112-3581 28 µM 1.47912263525778 0.105130755784403 no 461 0.0695537707908766 413 2877249
SGTC_323 4013-0906 34.3 µM 1.47735689458521 0.105400996547205 no 462 0.0697899972093308 398 2910086
SGTC_2361 9034121 116 µM 1.47471688480965 0.105805978008465 no 463 0.0701443373347812 418 6496917
SGTC_2903 5923464 63.88 µM 1.46879185338705 0.106718978976069 no 464 0.0709446271894216 399 2876576
SGTC_2309 7664088 163.95 µM 1.46155481168426 0.107841846713398 no 465 0.0719316225307434 500 704922
SGTC_3160 9100216 49.47 µM 1.45794579038141 0.108404975841906 no 466 0.0724277428702027 437 17191039
SGTC_2390 9097792 176.6 µM 1.45666929277333 0.108604658198761 no 467 0.0726038450283372 415 4497149
SGTC_1001 4048-4355 44.4 µM 1.45555485263695 0.108779206124747 no 468 0.0727578581460244 418 21824233
SGTC_1810 st050138 53 µM 1.45388670353473 0.109040854899653 no 469 0.072988859897783 373 3444541
SGTC_279 1273-0055 2.93 µM 1.45247636921599 0.109262418111924 no 470 0.0731845975651358 488 2847562
SGTC_613 3914-0030 117 µM 1.45243609329206 0.109268750197605 no 471 0.0731901932782236 187 1145395
SGTC_2259 7964009 200 µM 1.45054802460708 0.109565883824378 no 472 0.0734528785836441 407 313134
SGTC_252 miconazole 1.30953 nM 1.44896042357299 0.109816180223536 no 473 0.0736743176153351 426 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1568 digitonin 820 nM 1.44872847964022 0.109852782136954 no 474 0.0737067119003932 485 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2043 5101342 149 µM 1.44743194093572 0.11005754370093 no 475 0.0738879926357081 461 678451
SGTC_622 1348-1566 26.3 µM 1.44473933972747 0.110483659068232 no 476 0.0742655577168153 495 7340407
SGTC_2540 epiandrosterone 100 µM 1.44378214524769 0.110635423679966 no 477 0.0744001329707075 603 441302 A steroid.
SGTC_774 k060-0086 136 µM 1.44318605960753 0.110730009408518 no 478 0.0744840327224201 520 5911235
SGTC_2350 9023895 38.85 µM 1.44267757972222 0.110810739809786 no 479 0.0745556589288178 462 2997209
SGTC_2170 morpholine 200 µM 1.44102348651262 0.111073648797599 no 480 0.0747890238323135 418 121171 Reacts with secondary amines.
SGTC_1430 4049-0248 69.1 µM 1.44027055454665 0.111193471016076 no 481 0.0748954343525465 503 22774488
SGTC_2863 9028737 58.44 µM 1.43909777204524 0.111380292900394 no 482 0.0750614115964295 381 6460917
SGTC_2412 st077135 33.4 µM 1.43767758834759 0.111606825921861 no 483 0.0752627774668243 473 13258915
SGTC_429 1112-0049 25.5 µM 1.43705385414694 0.111706421666144 no 484 0.0753513459162495 427 2836170
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.43595156364798 0.111882587074132 no 485 0.0755080622014519 441 5282362
SGTC_1414 3917-0015 5.4 µM 1.43502899279712 0.112030182778084 no 486 0.0756394179803095 417 6618702
SGTC_1411 3909-8223 150 µM 1.4330566757747 0.11234618687092 no 487 0.0759208206120283 463 X1411
SGTC_1792 st045773 43.6 µM 1.43099969541678 0.112676433664638 no 488 0.0762151512135594 453 2919270
SGTC_2659 sanguinarine 24.21 µM 1.42992161407805 0.112849795510533 no 489 0.0763697589036949 464 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1263 0774-1208 64.8 µM 1.42672646102617 0.113364713230911 no 490 0.0768293776807423 538 906585
SGTC_2718 lomofungin 53.02 µM 1.42671353918479 0.113366799058396 no 491 0.0768312407317997 442 5351222 A RNA synthesis inhibitor.
SGTC_918 glabranin 770.725 nM 1.4244079692554 0.113739399529975 no 492 0.0771642043223006 492 124049 Also referred to as licorice root.
SGTC_3248 9135562 49.47 µM 1.42325147302432 0.11392662792414 no 493 0.0773316344656113 482 17650701
SGTC_726 3448-4391 34.2 µM 1.4220279451439 0.114124947212549 no 494 0.0775090692855353 505 1356692
SGTC_3227 9130768 49.47 µM 1.41601530843978 0.115103097307719 no 495 0.0783855112205869 429 17720899
SGTC_866 0495-0101 262 µM 1.41130862863497 0.115872939984874 no 496 0.0790768156715774 443 635694
SGTC_3132 9126706 49.47 µM 1.40859761082559 0.116318020398346 no 497 0.079477092864017 439 850858
SGTC_2739 tacrine 100.86 µM 1.40806693211854 0.116405286161711 no 498 0.0795556258194822 425 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3007 9078383 71.4286 µM 1.40699897354409 0.116581043952296 no 499 0.0797138465738725 469 6496995
SGTC_3094 9117742 49.47 µM 1.4010772994553 0.117559010166528 no 500 0.0805954795255086 513 17149698
SGTC_168 3970-0862 530.542 µM 1.39931582819553 0.117851035231577 no 501 0.0808591476120458 677 3135186
SGTC_1836 st055642 81 µM 1.39102040791656 0.119233189045783 no 502 0.0821096191751998 504 8571
SGTC_2295 7971645 200 µM 1.38734998264826 0.119848379451572 no 503 0.0826675344126341 493 2978226 YKL099C UTP11
SGTC_57 miconazole 162.5 nM 1.38361560541955 0.120476581909569 no 504 0.0832380936849003 459 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3204 9114183 49.47 µM 1.38274537560807 0.120623305813573 no 505 0.083371476684867 484 17027248
SGTC_1631 benzylvanillin 81.9 µM 1.38106271482301 0.12090736523764 no 506 0.083629839226624 510 75506
SGTC_1977 st070720 65.3 µM 1.37938685930483 0.12119074338213 no 507 0.083887754314059 449 682188
SGTC_2462 5162487 171.77 µM 1.37332467787243 0.122219725651996 no 508 0.0848257170509072 491 2259986
SGTC_1657 st012939 43.4 µM 1.37312526724892 0.122253677085174 no 509 0.084856703630336 451 24207257
SGTC_1618 st003135 44.5 µM 1.37098080383373 0.122619209543482 no 510 0.085190470085951 479 1270615
SGTC_795 0685-0265 78 µM 1.37080195615825 0.122649729454996 no 511 0.0852183504975402 517 302754
SGTC_3225 9130819 49.47 µM 1.36711898187696 0.123279404881802 no 512 0.0857940072177975 506 4547121
SGTC_2384 9036245 200 µM 1.36611963702189 0.123450652161732 no 513 0.0859507078609587 518 6462766
SGTC_3069 9117009 49.47 µM 1.36407042588226 0.123802325044101 no 514 0.08627270078928 375 41904981
SGTC_2283 7944793 200 µM 1.36343912474721 0.123910806190267 no 515 0.0863720788051423 517 2970533
SGTC_2047 4141938 200 µM 1.36301139953926 0.123984343175847 no 516 0.086439458982323 433 3807862
SGTC_3039 9090270 49.47 µM 1.3627478352295 0.124029671877634 no 517 0.086480998218953 461 17173750
SGTC_1456 k015-0012 13 µM 1.36262965712661 0.124050000321692 no 518 0.0864996286065778 575 2989616
SGTC_1038 k292-0204 154 µM 1.36113228940589 0.124307772428702 no 519 0.086735943603234 466 4454212
SGTC_2151 5563267 85.4165 µM 1.35787528094879 0.124869760039389 no 520 0.0872516311087876 527 5310824
SGTC_2999 9069765 71.4286 µM 1.35523288877649 0.125326999806372 no 521 0.0876716846282249 538 2097066
SGTC_742 0kpi-0133 140 µM 1.3551080530695 0.125348630264576 no 522 0.0876915666618981 527 2728852
SGTC_3123 9126162 49.47 µM 1.35257213010515 0.125788597466095 no 523 0.0880961805021673 496 25239884
SGTC_2975 9084847 53.72 µM 1.35220509816326 0.125852364397577 no 524 0.088154856624471 514 27211724
SGTC_1111 tnp00062 510.699 nM 1.35042631635182 0.12616172353024 no 525 0.0884396370762477 500 676306
SGTC_1699 st031318 29.054 µM 1.34246938585464 0.127552050412784 no 526 0.0897219251156469 500 5340658
SGTC_2167 5876490 200 µM 1.33863512683875 0.128225806217289 no 527 0.0903447424409621 530 686534
SGTC_658 3253-0951 102 µM 1.3353160153127 0.12881103273603 no 528 0.0908864695592754 636 1184878
SGTC_2612 dictamnine 15.46 µM 1.33282087472424 0.129252194737001 no 529 0.0912952968176832 521 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2526 patulin 37.61 µM 1.3326697829976 0.129278942623068 no 530 0.0913200968145126 596 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_961 1252-1571 372 µM 1.32721124640481 0.130247845385368 no 531 0.0922194065822651 535 6813498
SGTC_1695 st026914 34.495 µM 1.31923617519592 0.131672452045216 no 532 0.0935450839371029 540 3289191
SGTC_3263 9137018 49.47 µM 1.31685006992577 0.132100770002082 no 533 0.0939444428432957 509 43844957
SGTC_817 1391-0715 46 µM 1.3160339407226 0.132247489570043 no 534 0.0940813255481409 499 1353946
SGTC_1121 fusaric acid 630.51 nM 1.31477177585292 0.132474616297728 no 535 0.0942933078631941 550 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_881 0833-0569 170 µM 1.31126738586389 0.133106640326344 no 536 0.094883721500548 545 5418700
SGTC_924 2046-0044 21.3 µM 1.30949740451059 0.133426647706669 no 537 0.095182958182965 536 3623589
SGTC_182 3448-4371 550.524 µM 1.30773440273808 0.133745918876907 no 538 0.0954817051512648 571 3491403
SGTC_274 sirtinol 40.1 µM 1.30683197823899 0.1339095466837 no 539 0.0956348909951173 532 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1982 st072467 71.9 µM 1.30445182823987 0.134341775755576 no 540 0.0960397869096443 607 3163533
SGTC_632 0781-2353 4.65 µM 1.30373958080539 0.13447130407667 no 541 0.0961611945788558 573 6811515 YHR007C ERG11
SGTC_761 k216-0224 480 µM 1.30372030274714 0.134474811148679 no 542 0.0961644822292939 585 1340404
SGTC_2366 9070441 60.58 µM 1.30022514585762 0.1351116893994 no 543 0.0967619073031716 562 6837235
SGTC_1094 duloxetine 25.4 µM 1.29773211328494 0.135567225062625 no 544 0.09718970227963 550 60834 A selective serotonin reuptake inhibitor.
SGTC_2324 6149169 200 µM 1.29679854664276 0.13573808013159 no 545 0.0973502554509919 502 2888231
SGTC_2642 cholecalciferol 100 µM 1.29663453395445 0.135768111852028 no 546 0.0973784821518019 505 9821465 A vitamin D precursor, similar to steriods.
SGTC_2238 6671620 73.2395 µM 1.29490603408853 0.136084887385919 no 547 0.0976763233399112 529 729941
SGTC_1390 3413-2614 145 µM 1.29180292604572 0.136654850616572 no 548 0.0982127008987048 583 3421432
SGTC_1308 1187-1617 41.4 µM 1.29079824699515 0.136839734281451 no 549 0.0983868229172258 592 2882570
SGTC_287 k060-0039 29.6 µM 1.28690764449937 0.137557305682954 no 550 0.0990632402446011 542 5861974
SGTC_723 4182-0001 115 µM 1.28624328668921 0.137680094192283 no 551 0.0991790842076628 524 744821 YLR208W SEC13
SGTC_3108 9121785 49.47 µM 1.2811327177331 0.138627144859063 no 552 0.100073526822019 555 17140271
SGTC_2439 5492030 7.2 µM 1.28092076091481 0.138666518655995 no 553 0.100110749912523 546 5722370
SGTC_3015 9080845 49.47 µM 1.28089003663602 0.138672226731373 no 554 0.100116146438067 579 5296973
SGTC_2132 5317594 122.667 µM 1.2778736886826 0.139233394832354 no 555 0.100646983341704 499 794577
SGTC_176 1486-1328 72.834 µM 1.2760971731088 0.139564623864692 no 556 0.100960585395127 594 22310231
SGTC_2795 7780010 54.55 µM 1.27284542798641 0.140172294714491 no 557 0.101536448683427 529 953673
SGTC_2048 5246248 200 µM 1.27249262964854 0.140238331923791 no 558 0.101599070570732 515 677046
SGTC_1129 3453-1384 223 µM 1.26825391837519 0.141033390994742 no 559 0.102353643819275 623 1084452
SGTC_614 0462-0418 107 µM 1.2646423345172 0.141713226740277 no 560 0.102999785024244 511 5188303
SGTC_759 3486-0358 89.3 µM 1.2630092664855 0.142021359066031 no 561 0.103292924774556 618 875103
SGTC_2069 5228469 200 µM 1.26269313012241 0.142081061010852 no 562 0.103349741943148 539 2835210
SGTC_779 1360-0071 233 µM 1.26236547357158 0.142142956453201 no 563 0.103408653501548 617 7566
SGTC_3090 9117696 49.47 µM 1.2603865819014 0.142517163753738 no 564 0.103764969875114 542 7923821
SGTC_2178 5812956 200 µM 1.2596543722948 0.142655792898112 no 565 0.103897035967788 533 5403383
SGTC_2073 5212005 126 µM 1.25775488178372 0.143015848122026 no 566 0.10424020868279 474 691789
SGTC_148 3253-0744 288.01 µM 1.25675287166868 0.14320602990488 no 567 0.104421568176082 552 6893655
SGTC_2960 9079389 5.97 µM 1.24746190250513 0.144977592340642 no 568 0.106114090516229 591 16457355
SGTC_1235 benzylparaben 21.5 µM 1.24707798894192 0.145051111383122 no 569 0.106184451418464 568 7180
SGTC_1155 4088-0394 48.2 µM 1.24685616790998 0.145093601313144 no 570 0.106225120531663 587 2326248
SGTC_1663 st014140 55.4 µM 1.23086437529913 0.148178916923238 no 571 0.109186796778304 682 4207120
SGTC_120 rhodamine 6G 52.259 µM 1.23043949632972 0.148261483577463 no 572 0.109266285387243 703 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1591 genipin 88.4 µM 1.22330774605735 0.149651989420763 no 573 0.110606741288043 564 442424 A DNA cross-linking agent.
SGTC_1826 st055655 41.6 µM 1.22019971329872 0.150260688635749 no 574 0.111194587769963 612 676168
SGTC_3047 9092122 49.47 µM 1.22013523518135 0.150273333933945 no 575 0.111206806658984 581 17173831
SGTC_1399 3562-5772 25 µM 1.21914555813315 0.150467516074076 no 576 0.111394475479065 514 23847490
SGTC_42 0133-0086 60.653 µM 1.21867090726667 0.150560705455948 no 577 0.111484562161712 554 162923 Model of phenazepam hydroxylation.
SGTC_3330 9141424 71.43 µM 1.21779261846372 0.150733243432214 no 578 0.11165139504969 651 27261020
SGTC_2077 5212015 200 µM 1.21392379436898 0.151494832446307 no 579 0.112388412864829 580 780900
SGTC_1279 0874-0590 65.2 µM 1.21356830338953 0.151564939971648 no 580 0.112456308490432 624 3523074
SGTC_3229 9132204 49.47 µM 1.21268512111013 0.15173920854328 no 581 0.112625115293412 551 17682924
SGTC_2770 toltrazuril 17.5 µM 1.20823631700312 0.15261906583425 no 582 0.113478188079429 665 68591 Kills coccidiodes.
SGTC_2522 biochanin a 4.94 µM 1.20790301836401 0.152685119616714 no 583 0.113542284223687 573 5280373 A possible chelator.
SGTC_1405 3909-7894 12 µM 1.20389526395751 0.153480869145816 no 584 0.114315031276032 616 7104060
SGTC_3253 9135987 49.47 µM 1.20315334729111 0.153628479299656 no 585 0.114458492248219 558 4182430
SGTC_2088 5278280 127.392 µM 1.20283067771705 0.153692706269349 no 586 0.114520925335939 637 791502
SGTC_898 1000-0849 28.3 µM 1.20064018377513 0.154129191227138 no 587 0.114945403206789 628 6751807
SGTC_3012 9080433 71.4286 µM 1.19909357346248 0.154437867227669 no 588 0.11524578135277 642 17688859
SGTC_2588 indole-3-carbinol 100 µM 1.19753161432136 0.15475002108717 no 589 0.115549706409401 669 3712 Induces cell cycle arrest.
SGTC_506 n9-isopropylolomoucine 153 µM 1.19608962602865 0.155038568859296 no 590 0.115830792746892 613 6610355
SGTC_2634 4'-methoxyflavone 100 µM 1.19352842243229 0.155551951569753 no 591 0.116331243832679 577 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1140 3229-1848 2.98 µM 1.19166002932167 0.155927169900434 no 592 0.116697288393082 627 2849525
SGTC_1275 0867-0008 21.1 µM 1.19046967937229 0.156166531716085 no 593 0.116930920191689 629 3422836
SGTC_1607 st000305 50.6 µM 1.18956782054926 0.156348043334442 no 594 0.117108149985486 630 5457690
SGTC_1447 4239-0816 81.9 µM 1.18872741270726 0.156517312114351 no 595 0.117273474905891 594 1341554
SGTC_1384 3089-0840 101 µM 1.18099659144178 0.158080055616549 no 596 0.118802038690202 603 1069836
SGTC_1760 st045453 10.4495 µM 1.17618858095612 0.15905711692891 no 597 0.119759763284253 674 3323419 YIL048W NEO1
SGTC_413 propylparaben 100 µM 1.17238449985129 0.159832962052757 no 598 0.120521359869775 619 7175 A pharmaceutical preservative.
SGTC_2026 5148700 152 µM 1.16918453344488 0.160487511433465 no 599 0.121164645617672 634 79838
SGTC_1781 st038725 66.3 µM 1.1690517199552 0.160514716074653 no 600 0.12119139706776 718 4270275 YIL048W NEO1
SGTC_1831 st055328 12 µM 1.16788071718722 0.160754706945982 no 601 0.121427441618864 668 1103068
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.16636353795188 0.161065993120677 no 602 0.121733747003943 628 5355888
SGTC_2856 9022925 19.48 µM 1.16496893613621 0.161352476296426 no 603 0.122015783596819 665 4944862
SGTC_1860 st056228 74.6 µM 1.16179528657867 0.162005654545441 no 604 0.122659314552629 620 688679
SGTC_537 1334-0398 209 µM 1.16152532420153 0.162061295678545 no 605 0.122714165350918 677 5846986
SGTC_2789 5281112 71.43 µM 1.16070880483071 0.162229661770411 no 606 0.122880169983328 648 765948
SGTC_1345 1488-0192 31.4 µM 1.15869511580981 0.162645370517556 no 607 0.123290241206373 665 658348
SGTC_1870 st057514 26.5 µM 1.1583543758106 0.16271578184503 no 608 0.12335972485101 655 5393161
SGTC_1621 st003705 32.4 µM 1.15473861385059 0.16346417279776 no 609 0.124098740903817 718 24207032
SGTC_763 3453-1109 128 µM 1.15296006248585 0.163833116608447 no 610 0.124463388659531 691 1560353
SGTC_3305 9127027 53.8275 µM 1.15260354881161 0.163907137001431 no 611 0.124536572974296 656 41905295
SGTC_2335 9018011 154.17 µM 1.15031582649609 0.164382636805542 no 612 0.125006907317937 699 6458208
SGTC_3166 9102297 49.47 µM 1.15017927509964 0.164411047071782 no 613 0.125035020197745 676 25237072
SGTC_1245 0418-0076 17.2 µM 1.14835994319598 0.164789872736905 no 614 0.12541000137119 672 6790114
SGTC_232 clozapine 119 µM 1.14807263566844 0.164849748255479 no 615 0.125469289809105 646 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3179 9107801 49.47 µM 1.14793160982522 0.164879143505432 no 616 0.125498398890152 664 4818259
SGTC_2515 chrysin 20.77 µM 1.14563596927736 0.165358121292791 no 617 0.125972903909119 676 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_566 0958-0068 16.5 µM 1.14045245926118 0.166442951436 no 618 0.127048924080498 600 6815365
SGTC_2746 daunorubicin 9.88 µM 1.13799679728927 0.166958484692433 no 619 0.127560909839908 530 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1726 st035556 14.5795 µM 1.13694839217973 0.167178896628821 no 620 0.127779930239316 725 5919439
SGTC_948 3448-0295 75.3 µM 1.13667582439465 0.167236230754131 no 621 0.127836914660544 723 678569
SGTC_2364 9055074 200 µM 1.13272798848587 0.16806807162848 no 622 0.128664250148881 639 6470630
SGTC_293 4049-0273 38.5 µM 1.13146435607289 0.168334890733735 no 623 0.128929848798621 637 1380311
SGTC_3153 9100258 49.47 µM 1.13025068538607 0.16859141664862 no 624 0.129185303931671 614 25236848
SGTC_1965 Pectolinarigenin 58.4 µM 1.12887309300722 0.168882893990918 no 625 0.129475686443253 684 5320438 An anti-inflammatory.
SGTC_1910 st062352 60.4 µM 1.12796002884703 0.16907626260938 no 626 0.129668400141924 671 2245730
SGTC_2177 5811945 192 µM 1.12756174536805 0.16916065555782 no 627 0.129752525089924 672 5343475
SGTC_3159 9100096 49.47 µM 1.12749101125097 0.169175646355334 no 628 0.129767469414754 652 25236875
SGTC_187 1488-2104 32.728 µM 1.12662112574986 0.169360072360351 no 629 0.129951351622923 704 2852859
SGTC_224 benfluorex 43.875 µM 1.12598846492343 0.169494284954135 no 630 0.130085200942246 603 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_249 wiskostatin 11.211 µM 1.12593911244784 0.169504757451298 no 631 0.130095646242791 711 2775510 A n-wasp and actin depolymerizer.
SGTC_595 3909-8003 73.7 µM 1.12556476938547 0.169584205822354 no 632 0.130174893706467 680 699517
SGTC_807 1315-0151 48 µM 1.12303714579109 0.170121278900671 no 633 0.130710859352087 763 4011080
SGTC_205 1486-1330 71.903 µM 1.12137191965141 0.170475703481375 no 634 0.131064791847118 632 4118834
SGTC_2456 5770359 74.46 µM 1.12011606541212 0.170743310422676 no 635 0.131332152691751 710 3118787
SGTC_1521 st012942 49.4 µM 1.11905212508046 0.170970233151349 no 636 0.131558951154684 741 24207259
SGTC_1674 st016616 23.6 µM 1.1180624834615 0.171181482178921 no 637 0.131770154022861 676 625830
SGTC_2829 7992743 58.44 µM 1.11496064206242 0.171844682529287 no 638 0.132433643997995 702 16462845
SGTC_652 0437-0092 114 µM 1.11113762627097 0.17266433036369 no 639 0.133254557124051 666 3091274
SGTC_752 1896-0090 130 µM 1.11041703826526 0.172819101874018 no 640 0.13340967974146 700 772567
SGTC_104 0074-0074 590.992 µM 1.11020507634844 0.172864644943123 no 641 0.133455332898681 560 3943124
SGTC_2657 nystatin 74.44 µM 1.10986821855049 0.172937039425104 no 642 0.133527908708288 728 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2927 9011802 47.9 µM 1.10933621432905 0.173051412381128 no 643 0.133642583973649 668 43912568
SGTC_2541 muurolladie-3-one 83.07 µM 1.10806836368816 0.173324175517776 no 644 0.133916146287992 672 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_212 3807-4682 38.772 µM 1.10652344189184 0.173656917022022 no 645 0.134250011699395 855 3125501 YBL034C STU1
SGTC_2066 5222451 176 µM 1.10551645702733 0.173874017612796 no 646 0.134467933715447 754 2281147
SGTC_1026 k007-1105 30.6 µM 1.10531164653865 0.173918194781021 no 647 0.134512286542921 765 7066794
SGTC_107 0358-0022 2.6945 µM 1.10292081241355 0.174434420276101 no 648 0.135030777602793 556 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1671 st016596 74.5 µM 1.10176461733084 0.174684413068018 no 649 0.135282008277524 744 2829167
SGTC_549 1661-1316 519 µM 1.10174346967827 0.174688987736104 no 650 0.135286606452087 731 2857282
SGTC_1484 3473-2379 286 µM 1.0942288847729 0.176319359574594 no 651 0.136927303062325 820 671917
SGTC_2282 7944268 200 µM 1.0902388914488 0.17718893303245 no 652 0.137803962857575 734 2970414
SGTC_2906 7926292 26.41 µM 1.08807352276416 0.177661982329079 no 653 0.138281325663176 711 2966319
SGTC_3352 9151559 45.5865 µM 1.08657595425863 0.177989608819561 no 654 0.13861212832703 683 17159339
SGTC_2948 9070189 9.45 µM 1.08653205428733 0.177999218660842 no 655 0.138621833658115 644 6473636 YDL196W YDL196W
SGTC_1174 0739-0097 51.1 µM 1.08623809574252 0.178063575537019 no 656 0.138686833442661 724 728447
SGTC_2937 9044753 11.33 µM 1.08594093381188 0.178128648644989 no 657 0.138752562655177 746 6465530 YGL099W LSG1
SGTC_1848 st056003 16.4 µM 1.08364247062649 0.178632476948572 no 658 0.139261676158987 752 146492
SGTC_407 eburnamonine 100 µM 1.08109725741167 0.179191439364616 no 659 0.139826926636098 658 3195
SGTC_183 3914-0051 30.55 µM 1.07959396701296 0.179522097980242 no 660 0.140161514576283 726 1596232
SGTC_1090 efavirenz 20.7 µM 1.07701701342545 0.180089807411293 no 661 0.140736332506135 729 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_749 1000-0129 128 µM 1.07493510324355 0.180549279677017 no 662 0.141201892218464 772 708470
SGTC_2879 9041815 71.43 µM 1.07250169597281 0.181087257476646 no 663 0.141747376301908 629 4942971
SGTC_12 0849-0099 9.267 µM 1.07021504445882 0.181593704730146 no 664 0.142261262032018 722 6071388
SGTC_2192 5915882 198.485 µM 1.07006512029636 0.181626940847106 no 665 0.142294998896857 687 2876149
SGTC_1649 st011737 51.3 µM 1.06989447888274 0.181664774324274 no 666 0.142333404272466 727 1761035
SGTC_1364 1653-0028 37.6 µM 1.06427023774916 0.182914502281243 no 667 0.143603148264714 749 5718652
SGTC_1924 st058459 75.1 µM 1.05676367282846 0.184590826692308 no 668 0.145309728684394 721 688683
SGTC_2382 9035899 200 µM 1.0548781531448 0.185013387016422 no 669 0.145740527561945 764 6462679
SGTC_2626 ethyl orsellinate 100 µM 1.05207357376282 0.185643026877577 no 670 0.146382897688775 704 75653 A natural product.
SGTC_2874 9043904 71.43 µM 1.0520213043099 0.185654774195633 no 671 0.146394887673392 646 4463428
SGTC_2742 clothiapine 36.27 µM 1.05100519861835 0.185883230878317 no 672 0.146628101107898 706 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.0505572987573 0.185983990028254 no 673 0.146730980827434 713 4330530
SGTC_2033 5192550 145 µM 1.05052123318008 0.185992104780946 no 674 0.146739266965142 728 182073
SGTC_3011 9081274 71.4286 µM 1.04678029189198 0.186835008326928 no 675 0.147600461013056 785 6625322
SGTC_1741 st038134 10.228 µM 1.04662885473046 0.186869179645752 no 676 0.147635394189723 802 1272587
SGTC_2699 st077704 54.6 µM 1.04590842898706 0.187031794405808 no 677 0.147801656177007 749 645852
SGTC_1872 amphotericin b 148 nM 1.04539158991695 0.187148509419248 no 678 0.147921011033885 785 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_35 0133-0054 64.071 µM 1.04455479120956 0.187337574695356 no 679 0.148114391685293 688 99677
SGTC_853 0419-0306 21 µM 1.04274734659341 0.187746349307326 no 680 0.148532661625709 692 762713
SGTC_1043 0916-0009 19.3 µM 1.04191460323507 0.187934869146548 no 681 0.14872563650863 876 3101130
SGTC_361 000s-0510 1.45 µM 1.04172244217552 0.187978387942263 no 682 0.148770190530255 745 660
SGTC_863 0466-0191 129 µM 1.0405893789136 0.188235119728786 no 683 0.149033081334108 809 765160 YPR165W RHO1
SGTC_984 1492-0255 2.91 µM 1.04046832063345 0.18826256214746 no 684 0.149061187343392 720 1585198
SGTC_1939 st074455 53.6 µM 1.03745116540453 0.188947311218523 no 685 0.149762821772668 785 1644229
SGTC_1751 st044839 27.194 µM 1.03564131929149 0.189358794494736 no 686 0.150184753923428 766 5291326
SGTC_2563 tomatine 8.54 µM 1.03552192255924 0.189385959696196 no 687 0.150212616895806 816 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1078 idebenone 36.1 µM 1.03378548161174 0.189781306632468 no 688 0.150618230178104 805 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1819 st053448 58.6 µM 1.03357245896233 0.189829841826643 no 689 0.150668040082884 766 2857616
SGTC_134 0269-0018 6.916 µM 1.03097730067065 0.190421736783102 no 690 0.151275732319427 753 4378915
SGTC_1148 3909-7663 27.7 µM 1.02846835506739 0.190995044866053 no 691 0.151864784514994 797 4084526
SGTC_2899 9053889 58.44 µM 1.02736268071331 0.19124803335438 no 692 0.152124858725864 763 6470052
SGTC_2525 harmine 47.85 µM 1.02687081692356 0.191360642311409 no 693 0.152240648804824 730 5280953 A monoamine oxidase inhibitor
SGTC_861 0443-0273 110 µM 1.02586866875344 0.191590203203884 no 694 0.152476746383753 778 6149169
SGTC_2944 9067346 25.62 µM 1.02538790299656 0.191700391494132 no 695 0.152590096900575 748 6473075
SGTC_507 nimesulide 162 µM 1.02455764135343 0.191890773259434 no 696 0.152785979943274 788 4495 A COX2 inhibitor.
SGTC_202 3594-0513 34.79 µM 1.02358069224858 0.192114939109306 no 697 0.15301668433394 738 708429
SGTC_1932 st074806 40.9 µM 1.02314704725525 0.192214492441052 no 698 0.153119162613957 813 17251235
SGTC_628 1636-0253 16 µM 1.02283994955943 0.192285012969987 no 699 0.153191762949416 795 4456143
SGTC_292 k038-0015 474 µM 1.0220014794014 0.192477636042625 no 700 0.153390100107341 747 46368540
SGTC_319 1348-1596 45.5 µM 1.0209379116118 0.192722140806192 no 701 0.153641927945977 819 5380505
SGTC_2445 5742597 35.57 µM 1.02087646982947 0.192736271520946 no 702 0.153656484274054 734 1774255
SGTC_1675 st018485 24.5 µM 1.01960738483166 0.193028284143745 no 703 0.153957350616173 780 3323024
SGTC_2776 terbinafine 19.92 µM 1.0156614472542 0.193937956936593 no 704 0.154895316385217 753 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2696 st077691 74.316 µM 1.01492791094149 0.194107349515488 no 705 0.155070096190691 703 757133
SGTC_2852 9023854 51.95 µM 1.01488224023601 0.194117899046738 no 706 0.155080982460939 793 19798528
SGTC_781 4335-2806 94.4 µM 1.01436512517119 0.194237372442689 no 707 0.15520427948457 878 845254
SGTC_3230 9131665 49.47 µM 1.01034801710975 0.195167002662991 no 708 0.156164291792344 673 15943720
SGTC_1588 farnesol 29.9 µM 1.01016692597556 0.195208973969459 no 709 0.156207661091399 792 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2403 6032726 181.2 µM 1.00811298969836 0.195685396492752 no 710 0.15670011117827 748 2881040
SGTC_2237 6667747 47.222 µM 1.00525370181995 0.19634979908391 no 711 0.157387351243629 756 729940 YDL015C TSC13
SGTC_513 4245-1575 41.7 µM 1.00353404387608 0.196750047594873 no 712 0.157801629813719 899 719745
SGTC_2358 9037157 4 µM 1.00199610338101 0.19710841979737 no 713 0.158172737407371 794 2388925
SGTC_1058 3448-5425 97.3 µM 1.00081121990079 0.197384791569377 no 714 0.158459042082081 769 7279705
SGTC_791 1348-1292 225 µM 1.00017919262706 0.19753230649922 no 715 0.158611898446498 892 5437054
SGTC_2866 9034245 58.44 µM 0.999533523168043 0.197683074314078 no 716 0.158768153994948 790 6462273
SGTC_1273 0849-0096 14.1 µM 0.99749847946137 0.198158724465197 no 717 0.159261305746407 795 5286025
SGTC_2061 5245884 80.95 µM 0.997195139024431 0.198229683258961 no 718 0.15933489999414 808 573863
SGTC_822 1487-0950 154 µM 0.996030856538412 0.198502179969494 no 719 0.159617576461043 799 1958375
SGTC_951 1171-0579 82.7 µM 0.99543314905708 0.198642159293684 no 720 0.159762821440252 858 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1008 4106-0037 6 µM 0.993453003200437 0.199106322082983 no 721 0.160244621269175 803 2905394
SGTC_2591 skatole 100 µM 0.992916607845304 0.199232170036494 no 722 0.160375297785681 790 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_526 4469-0568 170 µM 0.989679715196965 0.199992619324245 no 723 0.161165346435926 786 2901964
SGTC_2964 9083345 53.42 µM 0.985952261443032 0.200870475601235 no 724 0.162078269745893 759 17741579
SGTC_2787 5284540 71.43 µM 0.98423437409788 0.201275834104502 no 725 0.162500144115744 819 736958
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.982178797705296 0.201761518802297 no 726 0.163005885497947 876 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2935 9038016 29.96 µM 0.978401040100839 0.202655942782188 no 727 0.163938006994487 863 6463195
SGTC_971 1315-0384 26.7 µM 0.977398376711904 0.202893731260419 no 728 0.164185983169362 789 6769120
SGTC_2163 5671233 125 µM 0.97667656895243 0.203065016032541 no 729 0.16436464935793 873 701023
SGTC_1214 0358-0031 63.7 µM 0.97652453863937 0.203101103786259 no 730 0.164402296877654 807 4301366
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.976480853746876 0.2031114740688 no 731 0.164413115674195 853 3256 An antibiotic and ribosome inhibitor.
SGTC_1261 0712-0010 12.7 µM 0.975108546093572 0.203437404774625 no 732 0.164753209941206 861 2840123
SGTC_2150 5556613 200 µM 0.972998532306896 0.203939153052598 no 733 0.165277015774812 864 743190
SGTC_1206 3978-0017 132 µM 0.972864116741329 0.203971141210476 no 734 0.165310420588842 775 3873677
SGTC_633 0437-0093 97.7 µM 0.971845427011157 0.204213665718932 no 735 0.165563726290302 825 2831118
SGTC_150 3970-0969 77.2 µM 0.967228066451815 0.205315094989176 no 736 0.166715017261269 873 6615640
SGTC_534 k292-0788 63.4 µM 0.966055539324051 0.205595351462153 no 737 0.167008195255153 932 4146317
SGTC_2628 lathosterol 100 µM 0.964795621825814 0.205896748883701 no 738 0.1673235946345 834 6710616
SGTC_102 gallobenzophenone 83.616 µM 0.95807731546845 0.207508321803222 no 739 0.169011886648917 847 70837
SGTC_797 k781-0471 270 µM 0.951653814980799 0.209056126920258 no 740 0.170636289720423 864 23738129
SGTC_894 0960-0238 55.9 µM 0.950929984175966 0.209230966234665 no 741 0.170819959780405 883 6741907 YDL195W SEC31
SGTC_598 3937-0236 20.2 µM 0.95091451585587 0.209234703503424 no 742 0.170823886203948 922 1379313
SGTC_3318 9139014 38.6185 µM 0.950767030643778 0.209270339073318 no 743 0.17086132622794 820 16643984
SGTC_1204 4049-0315 18.3 µM 0.950087169165686 0.209434654276076 no 744 0.171033981109465 837 588402
SGTC_1195 1502-0147 41.1 µM 0.949776254201503 0.209509824365959 no 745 0.171112976996297 887 817940
SGTC_2946 9065502 71.43 µM 0.945704991631334 0.2104955996175 no 746 0.172149537907584 699 16489101
SGTC_1192 1488-0095 21.4 µM 0.945483053109397 0.210549415746629 no 747 0.172206159355638 825 915875
SGTC_3083 9117465 49.47 µM 0.943781465371553 0.210962288582123 no 748 0.172640666965586 863 16420915
SGTC_271 rotenone 740 µM 0.943384300430599 0.211058724867357 no 749 0.172742185237428 863 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1611 st001856 99.4 µM 0.939578533624302 0.211984118788775 no 750 0.173716895777442 833 647478
SGTC_2029 5175081 200 µM 0.938240684169245 0.212309987404789 no 751 0.17406036741888 911 1380876
SGTC_3266 9136860 49.47 µM 0.936110786099938 0.212829384009326 no 752 0.174608075073321 848 4871271 YPR165W RHO1
SGTC_2012 4023501 200 µM 0.934747717280891 0.213162170610385 no 753 0.174959164664334 793 3477460
SGTC_3222 9128301 49.47 µM 0.926151770722018 0.215267809810511 no 754 0.177183556291316 889 4911358
SGTC_1437 4092-1038 11.6 µM 0.925798032100362 0.215354718448091 no 755 0.17727547503726 925 3977136
SGTC_2202 7226349 200 µM 0.925391327384669 0.215454665269124 no 756 0.1773811941945 848 844334
SGTC_3246 9135460 32.98 µM 0.925142159318425 0.215515911082485 no 757 0.177445982805184 812 41446951
SGTC_1715 st032160 10.2275 µM 0.914384105408398 0.218169868545601 no 758 0.180257525372723 860 5289825
SGTC_1231 0242-0792 125 µM 0.912454485078973 0.218647880387309 no 759 0.180764759445306 888 3707635
SGTC_417 st075190 100 µM 0.909753592799309 0.219317965671348 no 760 0.181476236808646 927 222757
SGTC_2159 5658611 73.75 µM 0.90880259496688 0.219554186730867 no 761 0.181727168289582 939 793844
SGTC_1669 st015249 58.4 µM 0.908510736611688 0.219626711554235 no 762 0.181804221913783 994 722793
SGTC_1357 1503-1303 39.5 µM 0.906201835995877 0.220200942427019 no 763 0.182414515712668 926 292895
SGTC_2034 5197015 53.07 µM 0.905874504226188 0.220282420497166 no 764 0.182501140250819 901 780676
SGTC_1403 3909-7815 62.9 µM 0.904588341762765 0.220602734081471 no 765 0.182841756923841 869 6615483
SGTC_2860 9025725 38.96 µM 0.901527234188589 0.221366162963388 no 766 0.183654030168988 846 40546248
SGTC_2393 9031399 185.94 µM 0.901238737046971 0.221438190899435 no 767 0.183730699440884 918 1526623 YDL150W RPC53
SGTC_3296 9122258 64.045 µM 0.898626712465181 0.222090934261331 no 768 0.184425762698555 906 4730474
SGTC_3217 9129673 49.47 µM 0.89827320342309 0.22217936026111 no 769 0.184519957440883 860 17248312
SGTC_2821 7996764 71.43 µM 0.89814118082248 0.222212389265956 no 770 0.184555143378784 947 2987135
SGTC_270 tamoxifen 5.46 µM 0.897731518858499 0.222314895060075 no 771 0.184664350793659 976 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.896881708996528 0.222527620852417 no 772 0.184891020634678 904 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1410 3909-8106 77.9 µM 0.895691999922808 0.22282562566373 no 773 0.185208642150722 904 1039210
SGTC_2940 9060638 45.86 µM 0.894910592435132 0.223021480529349 no 774 0.185417441976421 880 4027022
SGTC_631 k072-0230 41.5 µM 0.894215130860511 0.223195876021678 no 775 0.185603399051386 949 5773147
SGTC_97 0535-0701 19.132 µM 0.8940967008312 0.223225581533058 no 776 0.185635077176462 848 2832013 YGL099W LSG1
SGTC_2759 disulfiram 3.38 µM 0.892901423866886 0.223525515845132 no 777 0.18595498227169 874 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3275 9138069 49.47 µM 0.891731497206702 0.223819310792706 no 778 0.186268433402245 914 17617007
SGTC_1119 parthenolide 318.541 nM 0.890339979534744 0.224169037846289 no 779 0.186641680024738 974 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2397 5161689 200 µM 0.889695239848274 0.224331183990612 no 780 0.186814775347067 932 2259942
SGTC_1942 st076330 65.2 µM 0.887643855621883 0.224847531072152 no 781 0.187366177676987 947 24208414
SGTC_3075 9116269 49.47 µM 0.883112998459526 0.22599036230026 no 782 0.188587610901063 925 17015205 YNL244C SUI1
SGTC_164 4100-3994 89.624 µM 0.882794070110876 0.226070930042347 no 783 0.18867377248869 991 4615967
SGTC_2336 9001819 198.65 µM 0.881319798187165 0.226443571810659 no 784 0.189072376617107 959 2989602
SGTC_3212 9128307 49.47 µM 0.881229046679874 0.226466521784134 no 785 0.18909693035859 804 27243542
SGTC_316 k060-0003 58.6 µM 0.878773625912287 0.227087966686059 no 786 0.189762014560342 914 6152314
SGTC_3338 9144300 39.5675 µM 0.878292609043462 0.227209820247174 no 787 0.189892472853778 925 4901274
SGTC_2950 9072895 21.46 µM 0.878064142913556 0.22726770931771 no 788 0.189954455274472 967 17332245
SGTC_1767 st044992 70.3 µM 0.876470210994654 0.227671813228168 no 789 0.190387231909346 942 9600693
SGTC_421 streptovitacin 30 mM 0.876240319755575 0.227730130098404 no 790 0.190449700789439 955 91467 include heat shock
SGTC_1243 0416-0003 5.65 µM 0.875073062916804 0.228026359655515 no 791 0.190767076356175 910 2141977
SGTC_3344 9148862 3.898 µM 0.874046474501182 0.228287069032524 no 792 0.191046472439286 963 4905352
SGTC_493 zm226600 134 µM 0.873289533593622 0.228479406782943 no 793 0.191252641962694 942 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2671 danthron 100 µM 0.873064015978459 0.228536728128185 no 794 0.191314093011175 929 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_473 2-arachidonoylglycerol 10 µM 0.87237186010171 0.228712708526895 no 795 0.191502773367705 898 5282280 An endocannabinoid.
SGTC_2311 7694451 200 µM 0.871585570261857 0.228912714732126 no 796 0.191717252725184 910 2163142
SGTC_3030 9087619 49.47 µM 0.869858810323848 0.229352289792836 no 797 0.192188783765814 972 25236973
SGTC_1296 1068-0102 11.9 µM 0.86973875121009 0.229382870392487 no 798 0.19222159499281 942 767053
SGTC_1755 st041960 45.185 µM 0.868572246146655 0.229680113180887 no 799 0.192540570157031 949 2257073
SGTC_2814 7977482 42.97 µM 0.86732699546768 0.229997659455727 no 800 0.192881434751901 997 6456762
SGTC_3099 9120367 49.47 µM 0.865297543742118 0.230515707752209 no 801 0.193437749317299 961 24824940
SGTC_3262 9137218 49.47 µM 0.864862604385853 0.230626817412182 no 802 0.193557102415097 825 17650664
SGTC_105 0111-0055 734.78 µM 0.863731027772005 0.230916030264134 no 803 0.193867832342082 848 5179370
SGTC_1681 tripelennamine 100 µM 0.863629684428472 0.230941941875258 no 804 0.193895675959991 899 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_106 0092-0003 11.579 µM 0.863504606708577 0.230973924163685 no 805 0.19393004384876 905 1072148
SGTC_2418 pentamidine 31.67 µM 0.861910419904699 0.231381773174781 no 806 0.194368407297238 921 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_696 1560-0013 611 µM 0.86172768772451 0.231428548130957 no 807 0.194418692809566 953 1650269
SGTC_2518 prenyletin 46.28 µM 0.8610702586399 0.231596877453247 no 808 0.194599674210511 880 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2845 9003024 42.97 µM 0.857712390027464 0.232457695690438 no 809 0.195525648371111 973 2990173
SGTC_420 mitomycin C 81.9 mM 0.855753686356115 0.232960646628187 no 810 0.196067018832574 947 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1359 1582-0056 520 nM 0.855202782077976 0.233102215251623 no 811 0.196219448154978 1007 3661189
SGTC_2148 5546263 113.568 µM 0.855034393259991 0.233145496496424 no 812 0.196266053874265 964 792097
SGTC_1112 tnp00069 1.16933 µM 0.854765883338061 0.233214521255282 no 813 0.19634038443698 1005 145826
SGTC_3068 9116768 49.47 µM 0.853820755053583 0.233457571764665 no 814 0.196602156356431 927 41904888
SGTC_1417 3966-0327 90.4 µM 0.851119267439782 0.234153064273932 no 815 0.197351551714387 1008 651118
SGTC_1128 3448-9350 235 µM 0.850203358253852 0.234389123395395 no 816 0.197606017487538 866 619386
SGTC_3218 9131285 49.47 µM 0.849465280675004 0.23457944539867 no 817 0.197811220791569 1021 17156417
SGTC_15 0266-0086 27.098 µM 0.849278931441362 0.2346275112563 no 818 0.197863050706587 1055 1712902 YIL048W NEO1
SGTC_680 0417-1641 114 µM 0.848897579732826 0.234725891915283 no 819 0.197969142861358 914 2835990
SGTC_1250 0485-0349 40.2 µM 0.848226478944369 0.234899077067407 no 820 0.198155926705532 946 6842794 YDL195W SEC31
SGTC_1620 st003704 16.5 µM 0.846546928634663 0.235332813382221 no 821 0.198623852949224 990 2834414
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.846059563869393 0.235458755847873 no 822 0.19875975843941 824 6708630 An antioxidant.
SGTC_1896 st058441 89 µM 0.846041547630267 0.23546341223077 no 823 0.198764783483461 883 688759
SGTC_2561 acetosyringone 100 µM 0.843168244315754 0.23620668110782 no 824 0.19956717790194 1060 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3271 9137798 49.47 µM 0.842332884628554 0.236423014962293 no 825 0.19980082447373 906 6498326
SGTC_1516 st013856 110 µM 0.841987099754736 0.236512595089729 no 826 0.199897587171736 927 5281404 A mutagen and neurotoxin.
SGTC_2017 5132927 60.65 µM 0.841983734540093 0.236513466984687 no 827 0.199898529014904 1008 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1672 st016598 6.51 µM 0.841601107996861 0.236612613399227 no 828 0.200005634442639 933 4665860 YNL267W PIK1
SGTC_1973 st070275 50.2 µM 0.840380457792617 0.236929061777378 no 829 0.200347551317043 970 17118334
SGTC_685 1278-0033 54.9 µM 0.839064071947604 0.237270589791107 no 830 0.200716678025576 997 3590572
SGTC_1260 0700-1617 7.75 µM 0.837526733830825 0.237669784514728 no 831 0.201148278162446 974 2853078
SGTC_3224 9130643 49.47 µM 0.835310869071578 0.23824581741942 no 832 0.201771349623164 971 17644395
SGTC_1080 nisoldipine 24.4 µM 0.835076745903073 0.238306724371525 no 833 0.201837249360525 998 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1955 wogonin 32.4 µM 0.834368274320419 0.238491084619684 no 834 0.202036744640179 973 5281703 A flavanone.
SGTC_1393 3470-5649 58.2 µM 0.831897740760656 0.239134583508642 no 835 0.202733333598694 886 4108395
SGTC_547 1120-0019 610 nM 0.831749242729964 0.239173292941775 no 836 0.202775249614916 968 3676939
SGTC_1668 st014914 51.6 µM 0.831077954967606 0.239348322282998 no 837 0.202964796247377 1020 2839556
SGTC_440 fluspirilene 35.1 µM 0.830367027354018 0.239533763445362 no 838 0.203165651024877 986 3396 An atypical antipsychotic.
SGTC_348 k064-0012 10.7 µM 0.829668176870078 0.239716130787608 no 839 0.203363209312888 947 5066323
SGTC_76 0433-0009 400.328 µM 0.829218202046603 0.239833593289794 no 840 0.203490473494396 892 2841569
SGTC_870 0573-2213 57.6 µM 0.82846413143084 0.24003050806172 no 841 0.203703850085519 1018 3916321
SGTC_94 0334-0113 514.748 µM 0.827063272416615 0.240396556262643 no 842 0.204100599933788 994 6795178
SGTC_1659 st012954 42.1 µM 0.825244298184738 0.240872312478254 no 843 0.204616454252153 966 24207262
SGTC_2969 9091408 28.7 µM 0.825190590533234 0.240886367598895 no 844 0.204631697322999 934 4286311
SGTC_3097 9117246 49.47 µM 0.825071592016195 0.240917510719541 no 845 0.204665473368521 1052 16423892
SGTC_2063 5246145 200 µM 0.824281627005214 0.241124308104006 no 846 0.204889777835814 1034 711240
SGTC_3020 9089140 49.47 µM 0.822098323685902 0.241696355786988 no 847 0.205510469738575 1037 17217859
SGTC_1989 st071868 50.2 µM 0.821764758062907 0.241783818200308 no 848 0.205605397419944 1046 16414057
SGTC_2257 7960413 200 µM 0.819209567693338 0.242454370030151 no 849 0.206333428539676 1038 2974689 YIL048W NEO1
SGTC_2117 5521686 200 µM 0.818961721823974 0.242519465118288 no 850 0.206404126581651 982 803312
SGTC_2482 5981709 142.65 µM 0.816223618795945 0.243239239412994 no 851 0.207186125306591 998 877755
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.813496543033109 0.24395726117601 no 852 0.207966713751564 1082 368090
SGTC_1690 st023502 41.2 µM 0.812312859419207 0.244269273093999 no 853 0.208306066791799 1004 24207482
SGTC_2961 9083290 32.55 µM 0.812113573884857 0.244321824717323 no 854 0.20836323254243 980 17741490
SGTC_2479 5617353 43.85 µM 0.810871780850503 0.24464942295947 no 855 0.208719653633434 998 2731746
SGTC_1735 st034310 56.75 µM 0.809911407407093 0.244902941830605 no 856 0.208995547540756 990 871153
SGTC_412 gemfibrozil 100 µM 0.808823925990414 0.245190185188767 no 857 0.209308215912779 994 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_214 4373-3496 70 µM 0.808302839152391 0.245327887330136 no 858 0.209458134260086 1152 3779166
SGTC_890 0929-0006 47.2 µM 0.807494375013576 0.245541613901277 no 859 0.20969085697974 995 1378169
SGTC_209 4077-0173 175.592 µM 0.8072562936079 0.24560457245328 no 860 0.209759419542719 932 15993494
SGTC_1466 k213-0079 57.5 µM 0.806871225378924 0.245706418738859 no 861 0.20987033919051 1033 3657981
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.805174723239762 0.246155394697381 no 862 0.210359430281552 999 5377381
SGTC_1109 tnp00067 928.257 nM 0.804903000190091 0.246227346525452 no 863 0.210437828486351 998 676295
SGTC_2825 7998094 58.44 µM 0.804673660582348 0.246288084060641 no 864 0.210504011460772 979 2987815
SGTC_1365 1672-3266 55.4 µM 0.803012028643408 0.246728384923254 no 865 0.210983891071206 1056 6415873
SGTC_1783 st039459 87.517 µM 0.801649268814906 0.247089804704545 no 866 0.211377934611856 1093 729761
SGTC_740 k014-0057 261 µM 0.800936685410644 0.247278902823315 no 867 0.211584150414384 1067 4012779
SGTC_2638 epoxomicin 18 µM 0.800663637509236 0.247351381990227 no 868 0.211663199441724 1047 9915668 A protesome inhibitor.
SGTC_2894 9048625 32.47 µM 0.800157157415833 0.247485854599355 no 869 0.211809874269617 1055 4092861
SGTC_2549 cedrol 20.94 µM 0.799765382814492 0.247589899203593 no 870 0.211923371578401 1013 6708665 A sedative which affects the nervous system.
SGTC_2252 omeprazole 400 µM 0.79905463531393 0.247778713904347 no 871 0.21212936629313 966 4594 A proton pump inhibitor.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.798631389169362 0.247891188509131 no 872 0.212252090583402 1019 616764
SGTC_3175 9106517 49.47 µM 0.798276311947513 0.247985568731756 no 873 0.212355080643669 1008 41468073
SGTC_611 3453-1652 23.7 µM 0.796231369364889 0.248529491479491 no 874 0.212948783855555 1071 1560575
SGTC_1387 3342-1166 1.8 µM 0.796011086261169 0.248588121240977 no 875 0.21301279585234 981 3418228
SGTC_2773 thioridazine 9.09 µM 0.795719096024205 0.248665847670854 no 876 0.21309766250314 1096 5452 An antipsychotic.
SGTC_1807 st050092 58.9 µM 0.795558418125684 0.248708624893401 no 877 0.213144371774785 1024 5008496
SGTC_1415 3966-0071 78.1 µM 0.793021750914646 0.249384479930451 no 878 0.213882575159324 1033 2893185
SGTC_3215 9129942 49.47 µM 0.792706791995968 0.249468463853275 no 879 0.213974336107154 995 17682944
SGTC_1222 0366-0074 1.18 µM 0.792588169726289 0.249500098425283 no 880 0.214008901766764 1104 286520
SGTC_362 0310-0100 9.03 µM 0.792416712014958 0.249545827091344 no 881 0.214058869030313 1026 790235
SGTC_3155 9099265 49.47 µM 0.792366745898913 0.249559154153029 no 882 0.214073431741557 966 25236499
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.790779342328833 0.249982746345198 no 883 0.214536383322199 1067 6710655
SGTC_2995 9067767 71.4286 µM 0.790652490062494 0.250016612812218 no 884 0.214573403710227 995 11673567
SGTC_1087 pterostilbene 9.05 µM 0.789349575288863 0.250364600207344 no 885 0.214953859428035 1064 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3010 9080089 71.4286 µM 0.78859368450079 0.250566603994866 no 886 0.215174761667202 1050 17027233
SGTC_3231 9132313 49.47 µM 0.787978451048317 0.250731082322083 no 887 0.215354655308001 1045 4905967
SGTC_85 0868-0259 160.055 µM 0.786956713086315 0.251004363033914 no 888 0.215653603173257 992 83173
SGTC_974 1326-0144 138 µM 0.786956452470006 0.251004432760156 no 889 0.215653679457041 1073 5411856
SGTC_2056 5235370 200 µM 0.786536038578741 0.251116925174189 no 890 0.21577675721301 994 5511916
SGTC_2158 5657123 3.6195 µM 0.786489883375743 0.251129276795402 no 891 0.215790271803022 1051 2858827
SGTC_358 0075-0058 9.45 µM 0.785829869427114 0.25130593866819 no 892 0.215983582505779 1082 1069125
SGTC_2262 9014885 67.46 µM 0.78209472890499 0.252306937519125 no 893 0.217079452146428 1016 6457424
SGTC_307 1501-1223 22.3 µM 0.781561118885763 0.252450113727417 no 894 0.217236272245409 1069 2830329
SGTC_3140 9094243 49.47 µM 0.780992507225335 0.252602728552262 no 895 0.217403450801353 1139 19291112
SGTC_213 1246-0773 967 nM 0.779386409916996 0.253034065905516 no 896 0.2178760634424 1059 6251622
SGTC_2504 purpurogallin 52.29 µM 0.779328903832823 0.253049517060352 no 897 0.217892996250403 1008 5281571 An antioxidant.
SGTC_1288 0973-0013 65.5 µM 0.779214301532597 0.253080310723917 no 898 0.217926743442849 1086 4315430
SGTC_2971 9092186 9.93 µM 0.778306164042055 0.253324397155862 no 899 0.218194271244309 997 25236400
SGTC_1647 st011722 22.4 µM 0.777236126744009 0.253612157263062 no 900 0.218509735775742 1040 2854783
SGTC_11 0438-0307 1.3 µM 0.777043408323835 0.253664002363542 no 901 0.218566580221631 1060 4011476
SGTC_2997 9067075 71.4286 µM 0.776121266331722 0.253912153976721 no 902 0.21883869408814 1065 27209819
SGTC_2375 9072683 200 µM 0.775305531792333 0.254131777129134 no 903 0.219079570695489 1159 16798029
SGTC_2555 cholic acid 100 µM 0.774967349467398 0.254222856382927 no 904 0.219179476559929 1051 6708657 Influences liver metabolism.
SGTC_2834 9001755 58.44 µM 0.774411148888938 0.254372689522701 no 905 0.219343846353291 975 2989575
SGTC_151 3013-0144 2.285 µM 0.773755352835277 0.25454941181837 no 906 0.219537739819849 1048 906558 YHR107C CDC12
SGTC_452 diindolylmethane 8 µM 0.772766984766856 0.25481587626229 no 907 0.219830147852838 989 3071 Inhibits expression of several cancer promoting factors.
SGTC_1207 2099-0101 141 µM 0.77245508223754 0.25489999561417 no 908 0.219922470390825 1125 5837381
SGTC_2246 7293507 91.5585 µM 0.770278102847548 0.255487526115144 no 909 0.220567471328663 1121 887656
SGTC_2381 9035592 200 µM 0.769183379861076 0.255783240759261 no 910 0.220892227730736 1009 4749657
SGTC_1205 4161-2785 76 µM 0.768526838020864 0.255960676355604 no 911 0.221087126208108 982 3498106
SGTC_2312 7706453 155.7 µM 0.767431544835873 0.256256830829432 no 912 0.221412489631147 1062 976098
SGTC_2298 7976326 193.81 µM 0.767137239611407 0.256336437959085 no 913 0.221499961409069 1004 2235818
SGTC_3000 9075062 71.4286 µM 0.766807799644182 0.256425564033015 no 914 0.221597899170139 1024 17057871
SGTC_3336 9143619 71.43 µM 0.766355803185388 0.256547872580847 no 915 0.221732311475203 1117 45595730
SGTC_1116 jasmonic acid 1.58368 µM 0.763629335932234 0.257286288370981 no 916 0.222544081051044 1094 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_527 4476-4215 268 µM 0.763376717095114 0.257354761624647 no 917 0.222619380650087 1051 4418754
SGTC_1945 st075991 56.6 µM 0.763207624412645 0.257400600100954 no 918 0.222669791225309 1048 1084980
SGTC_756 0508-1999 28.3 µM 0.762727682581039 0.257530728198837 no 919 0.22281290880887 1090 6753853
SGTC_1974 st069448 26.9 µM 0.758607551449633 0.25864923609551 no 920 0.224043677034156 1088 6323587 YNR016C ACC1
SGTC_841 0251-0215 91.2 µM 0.757608751803324 0.258920762342855 no 921 0.224342619660137 1119 3888614
SGTC_968 1309-0633 340 µM 0.756345560281233 0.259264375252166 no 922 0.224721019336722 1097 3761976
SGTC_1057 3448-5381 134 µM 0.755570548949169 0.259475310146975 no 923 0.224953359569313 1117 5497911
SGTC_2580 diallyl disulphide 81.36 µM 0.752498028517525 0.260312429658661 no 924 0.225875807503172 1073 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_734 2023-0417 80 µM 0.752084406162051 0.260425228765607 no 925 0.226000150493548 1075 3935732
SGTC_2273 7815444 169.05 µM 0.75130727073485 0.260637229720623 no 926 0.226233877260203 1094 2824616
SGTC_964 1287-0107 19.4 µM 0.748978019464794 0.261273176403703 no 927 0.226935226892958 1118 51516812 YPR165W RHO1
SGTC_1928 4'-methoxychalcone 40.3 µM 0.748903725737879 0.261293473650797 no 928 0.226957617281199 1152 641818
SGTC_2112 5488546 200 µM 0.74704311070125 0.26180206275457 no 929 0.227518769196693 1116 600757
SGTC_1298 1079-1278 263 µM 0.746506554892367 0.261948821671079 no 930 0.227680736699753 1157 2840950
SGTC_489 paxilline 115 µM 0.746423779233148 0.261971466251014 no 931 0.227705729564931 1119 105008 A toxic potassium channel blocker.
SGTC_2208 7283366 200 µM 0.745419850960317 0.262246186455528 no 932 0.228008973524105 1130 898663
SGTC_2819 7996655 46.38 µM 0.745032445853672 0.262352237473188 no 933 0.228126052813289 1004 6456960
SGTC_3085 9117376 49.47 µM 0.744708440670582 0.262440949809419 no 934 0.22822399770481 1106 16480349
SGTC_773 4358-1457 44.6 µM 0.744705224201017 0.262441830552961 no 935 0.228224970143434 1168 1186886
SGTC_2476 5806916 10.51 µM 0.744098951011713 0.262607869154352 no 936 0.228408306946991 1056 2870194
SGTC_2933 9026794 32.47 µM 0.743379469546805 0.26280498156432 no 937 0.22862598523193 1115 17586027
SGTC_2783 7738165 71.43 µM 0.743079573595193 0.26288716475884 no 938 0.228716752795355 1056 17201110
SGTC_2685 mycophenolic acid 18.85 µM 0.742627037443032 0.263011202195577 no 939 0.22885375727185 1094 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1153 4055-0057 267 µM 0.742588289749991 0.263021824095231 no 940 0.228865490204161 1141 882706
SGTC_682 0kpi-0099 17 µM 0.741363998321166 0.263357551801755 no 941 0.229236383596728 1146 1714895 YML126C ERG13
SGTC_1878 temozolomide 1 mM 0.738439255083358 0.264160465651169 no 942 0.230123783802447 1102 5394 DNA alkylating agent.
SGTC_2413 inermin 26.06 µM 0.737701090798932 0.264363306757726 no 943 0.230348054562876 1139 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2532 xanthone 78.9 µM 0.737677453664625 0.264369803345943 no 944 0.230355238069837 1025 7020 An insecticide.
SGTC_1799 st045822 46.1415 µM 0.736142403157894 0.264791880847617 no 945 0.230822019847773 1129 3674992
SGTC_2374 9071832 200 µM 0.735614333011048 0.264937158179581 no 946 0.230982718695747 1104 17381698
SGTC_113 0099-0221 2.5 µM 0.735314418717384 0.265019685606106 no 947 0.231074014450345 1113 89219
SGTC_785 1270-0111 65.3 µM 0.735083995838529 0.265083099948441 no 948 0.231144170269284 1150 6741994
SGTC_754 3474-0146 171 µM 0.734202904055279 0.26532565499021 no 949 0.231412541914001 1105 24762078
SGTC_1474 0330-0125 5.35 µM 0.732503822872654 0.265793711541871 no 950 0.231930555120171 1154 X1474
SGTC_1916 st067606 49.2 µM 0.730886171446801 0.266239724715512 no 951 0.232424341636654 1163 19590279
SGTC_1768 st044301 37.178 µM 0.729280655069147 0.266682766345763 no 952 0.232915001544585 1183 3931349
SGTC_2614 arthonioic acid 13.39 µM 0.72863116219142 0.2668620994778 no 953 0.233113655614609 1112 6710684
SGTC_2983 9022671 12.99 µM 0.727773007170998 0.267099140244272 no 954 0.233376275339786 1118 6405161
SGTC_2424 5537928 59.2 µM 0.726658467104711 0.267407158647926 no 955 0.233717601049012 1206 5382802
SGTC_385 1494-0393 12.4 µM 0.723900058992865 0.268170252136509 no 956 0.234563546884297 1139 3090647
SGTC_2031 5180455 200 µM 0.720885441084389 0.269005475589935 no 957 0.235490000531085 1149 29949
SGTC_818 4072-2707 53.5 µM 0.720740367577494 0.269045702244494 no 958 0.235534635446202 1133 882871
SGTC_474 dl-dihydrosphingosine 5 µM 0.719174906298347 0.269479972575096 no 959 0.236016579349811 1194 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_290 2043-6722 48.1 µM 0.718514079071449 0.269663396247047 no 960 0.23622018502937 1173 773758 YLR208W SEC13
SGTC_2113 5491891 107.031 µM 0.716891528749483 0.270114027417355 no 961 0.236720514698498 1193 789979
SGTC_605 1315-0399 119 µM 0.715764604835435 0.270427229703482 no 962 0.237068355702813 1196 24020461
SGTC_289 k017-0060 526 µM 0.711480928187352 0.271619431672488 no 963 0.238393132560426 1160 5512909
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.711329371840137 0.271661659624941 no 964 0.238440077260143 1185 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2545 solidagenone 89.61 µM 0.710436054957199 0.271910629761874 no 965 0.238716885697287 1012 6708572 An anti ulcer agent
SGTC_2093 5331342 194.4 µM 0.707641080719655 0.272690329988891 no 966 0.239584087429192 1175 33839
SGTC_446 go6976 132 µM 0.706643223750936 0.272968965763499 no 967 0.239894110396382 1148 3501 A protein kinase C inhibitor.
SGTC_49 0717-0965 32.132 µM 0.706351276574031 0.273050514078746 no 968 0.239984856466495 1276 5889349 YGL099W LSG1
SGTC_661 1304-0007 33.6 µM 0.705053817941238 0.273413073489991 no 969 0.240388372458955 1178 3117130
SGTC_2018 5133068 143 µM 0.704696229267008 0.273513039282553 no 970 0.240499649219444 1174 785362
SGTC_1254 0550-0035 264 µM 0.703680289846015 0.273797149159592 no 971 0.240815948828406 1213 15121435
SGTC_3071 9117417 49.47 µM 0.702259136181331 0.274194822874354 no 972 0.241258786147103 1111 45595590 YGL055W OLE1
SGTC_2986 9022445 71.43 µM 0.699947950112613 0.274842158136021 no 973 0.241979905301222 1155 6459286
SGTC_1325 1431-0015 227 µM 0.697771214454249 0.275452523491316 no 974 0.242660141872803 1145 1103340
SGTC_1841 st054148 70 µM 0.696422550475204 0.275831028521169 no 975 0.243082122384571 1150 675442
SGTC_1321 1326-2144 215 µM 0.695779217890526 0.276011670980306 no 976 0.243283553017153 1178 3513030
SGTC_1432 4049-0298 68.4 µM 0.695256737359938 0.276158421921592 no 977 0.243447210635645 1207 741646
SGTC_3323 9138564 53.9225 µM 0.694194434995881 0.276456912558045 no 978 0.243780141047796 1216 43912313 YNL103W MET4
SGTC_2967 9089538 49.85 µM 0.691959441811415 0.2770854274013 no 979 0.244481399840205 1211 728216
SGTC_588 3970-1144 52.9 µM 0.691148862586268 0.27731354755962 no 980 0.244735998128932 1137 1888707
SGTC_2576 guaiol 23.12 µM 0.690374545162198 0.277531548348371 no 981 0.244979340037635 1205 227829
SGTC_721 1187-1332 279 µM 0.689498790080988 0.277778208704877 no 982 0.245254717187345 1145 25730
SGTC_1887 st057648 70.8 µM 0.689271177946337 0.277842334208086 no 983 0.245326316011691 1191 688672
SGTC_490 phenamil 164 µM 0.689053367252713 0.277903705102983 no 984 0.24539484216376 1144 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1850 st056238 17 µM 0.686118289367766 0.278731344818465 no 985 0.24631925929492 1220 5393177
SGTC_1937 st074714 47.2 µM 0.685540999285945 0.278894271443792 no 986 0.246501299066898 1185 17250970
SGTC_2207 7258803 200 µM 0.68154174244923 0.280024238803013 no 987 0.247764381693257 1176 3666799
SGTC_973 1325-0077 65.9 µM 0.679120045654453 0.280709552633864 no 988 0.248530901088136 1258 2835149
SGTC_959 1222-0044 107 µM 0.677689272199749 0.281114826812273 no 989 0.248984364884418 1204 6083612
SGTC_1985 st071382 65.5 µM 0.676294072762695 0.281510296441126 no 990 0.249426977623782 1264 6123237
SGTC_624 k048-0052 28 µM 0.674490759476595 0.28202184333 no 991 0.249999679274407 1192 6835531
SGTC_3050 9093513 49.47 µM 0.674490759476595 0.28202184333 no 992 0.249999679274407 1238 25236664
SGTC_1623 st003709 20.3 µM 0.673652895542451 0.282259672887634 no 993 0.250266007839606 1228 16192618
SGTC_1851 st056236 18.9 µM 0.672405528228635 0.282613919596786 no 994 0.250662782189772 1245 5393171
SGTC_2640 pentamidine 10.38 µM 0.672228217476009 0.282664292395576 no 995 0.250719209898935 1249 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1925 st057770 10.1 µM 0.671490753286483 0.282873847319818 no 996 0.250953974050723 1174 5989122
SGTC_2015 5119600 184 µM 0.671260608896214 0.282939259516377 no 997 0.251027261964537 1238 2828786
SGTC_3086 9117350 49.47 µM 0.667110069250301 0.284120180765473 no 998 0.252350914413631 1177 2679265
SGTC_1004 4084-0029 199 µM 0.66600313581509 0.284435525769166 no 999 0.252704548026881 1251 716894 YLR208W SEC13
SGTC_2885 9057732 51.95 µM 0.665145465327132 0.284679975255757 no 1000 0.252978728583187 1253 6471414
SGTC_2396 5342950 42.78 µM 0.663489781921593 0.285152154355643 no 1001 0.253508460778452 1251 1886677
SGTC_708 3448-5400 146 µM 0.660393583609815 0.286036149680571 no 1002 0.254500644341477 1237 3462195
SGTC_2355 9061122 103.12 µM 0.653330397580824 0.288057618876838 no 1003 0.256771649821696 1247 5302957
SGTC_1313 1220-0047 237 µM 0.651335561531307 0.288629755440499 no 1004 0.257414948651068 1289 3528706
SGTC_2010 4012422 159 µM 0.650113444293132 0.288980533648003 no 1005 0.257809472785738 1251 952393
SGTC_1490 4089-0339 670 nM 0.648022298818166 0.289581209454619 no 1006 0.25848526393626 1232 742542
SGTC_286 k060-0067 22.9 µM 0.645502280473637 0.290305855716436 no 1007 0.259300870464818 1239 5985051
SGTC_1732 st034308 51.822 µM 0.643434110863875 0.290901203937934 no 1008 0.259971227851797 1244 830119
SGTC_2052 5265182 7.135 µM 0.643314974520907 0.29093551618386 no 1009 0.26000987081299 1299 1239884
SGTC_2920 7982904 15.77 µM 0.641812043435596 0.291368535022968 no 1010 0.260497614490708 1252 6456808
SGTC_2143 5623677 140.463 µM 0.640768986187886 0.29166923341255 no 1011 0.260836392827232 1245 5375313
SGTC_1000 4048-0884 8.67 µM 0.639674337679355 0.291984960291313 no 1012 0.261192171254964 1276 13040088
SGTC_3297 9117502 71.43 µM 0.635985325359333 0.293050143401256 no 1013 0.262392993398394 1274 7453720
SGTC_1464 k208-0027 110 µM 0.635640089450855 0.293149920645189 no 1014 0.262505516724175 1352 X1464
SGTC_3049 9092223 49.47 µM 0.634389037601083 0.293511621275145 no 1015 0.262913481010151 1261 8623917
SGTC_896 0964-0007 44.5 µM 0.633503582026201 0.293767746572127 no 1016 0.263202421217532 1269 6756758
SGTC_1450 4112-4260 37.6 µM 0.631427108032136 0.294368788988808 no 1017 0.263880647981219 1286 1633175
SGTC_1101 ebselen 5.29 µM 0.631310183220194 0.294402650150728 no 1018 0.26391886494054 1344 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2893 9048488 25.97 µM 0.630513846389595 0.294633315316098 no 1019 0.264179223229285 1250 6467338
SGTC_1704 st028805 70.8 µM 0.630247514259676 0.294710479091448 no 1020 0.264266328352547 1286 2876101
SGTC_1554 st069299 38.7 µM 0.629193012109276 0.295016088956153 no 1021 0.264611351556665 1288 24207999
SGTC_430 0958-0115 16.4 µM 0.62763706519767 0.295467291148468 no 1022 0.265120860935802 1303 6833180
SGTC_594 1487-1584 10.8 µM 0.625481175851967 0.296092992005578 no 1023 0.26582764966228 1262 5013332
SGTC_1830 st055982 50.3 µM 0.624349293832135 0.296421739839086 no 1024 0.266199108827499 1274 455313 An antimicrobial agent.
SGTC_908 3448-7491 47.7 µM 0.623479536329653 0.296674468914406 no 1025 0.266484722838929 1307 1203031
SGTC_3287 9117173 37.0625 µM 0.621661392783053 0.297203092968594 no 1026 0.267082271439832 1283 2789709
SGTC_2342 7990637 118.86 µM 0.620106130426923 0.29765562585268 no 1027 0.267593958184154 1344 2033102 YER133W GLC7
SGTC_2269 7935389 174.42 µM 0.618683495977624 0.298069843294663 no 1028 0.268062442266466 1294 97605
SGTC_2747 doxorubicin 7.63 µM 0.616768671943432 0.298627782046753 no 1029 0.268693659217334 1221 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_378 3970-0959 8.33 µM 0.614814437021817 0.299197693458987 no 1030 0.269338636954453 1333 6615653
SGTC_90 0870-0863 4.608 µM 0.613066778938619 0.299707778753061 no 1031 0.26991609268647 1297 1738164
SGTC_368 fentichlor 4.58 µM 0.611888984756797 0.300051761086365 no 1032 0.270305605001922 1292 7329 A pesticide.
SGTC_1139 k015-0024 46.9 µM 0.611693890789206 0.300108756766835 no 1033 0.270370152309883 1308 2766652
SGTC_1123 mangostin 811.285 nM 0.611573194899654 0.30014401989017 no 1034 0.270410088692102 1324 5281650 An antioxidant.
SGTC_2529 gangaleoidin 93.61 µM 0.611131786927781 0.300272999836802 no 1035 0.270556168789228 1372 4565183
SGTC_1809 st050081 57.6 µM 0.608948715027953 0.300911264125247 no 1036 0.271279216406353 1375 5036894
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.602910634376472 0.302679794325061 no 1037 0.27328407054359 1283 2333 A French combination drug.
SGTC_2936 9038235 15.59 µM 0.601668126187185 0.30304429706571 no 1038 0.273697535402323 1326 4749415
SGTC_2546 rhodinyl acetate 100 µM 0.600746686276373 0.3033147378351 no 1039 0.274004359262788 1338 6708682
SGTC_2387 9077560 195.08 µM 0.600248289789223 0.303461061144415 no 1040 0.274170387646973 1297 5303272
SGTC_2709 st078560 56 µM 0.598758547409899 0.303898619741368 no 1041 0.27466695429854 1385 17250903
SGTC_1465 k213-0056 144 µM 0.598710918324315 0.303912613724301 no 1042 0.274682837522301 1308 24048857 YMR208W ERG12
SGTC_1048 3161-0300 24.5 µM 0.597911866001837 0.304147427488905 no 1043 0.274949370936484 1330 2165101
SGTC_3139 9095020 49.47 µM 0.596432870722847 0.3045822660416 no 1044 0.275443043396099 1173 25236292
SGTC_2139 5578692 56.4705 µM 0.59498669829431 0.305007721570975 no 1045 0.275926181227272 1316 650991 YMR113W FOL3
SGTC_777 1315-0167 517 µM 0.594387524768233 0.305184072241032 no 1046 0.276126475235039 1303 4221767
SGTC_2190 6049624 200 µM 0.591231093939555 0.306113829185988 no 1047 0.277182795756752 1310 2265554
SGTC_1491 4138-0063 26.5 µM 0.589748365981289 0.306551012932606 no 1048 0.277679682058946 1338 23883227
SGTC_864 0469-0573 172 µM 0.589724646289389 0.306558008946216 no 1049 0.277687634448676 1314 689425
SGTC_2307 7538926 6.34 µM 0.587397236051685 0.30724481032887 no 1050 0.278468474845096 1363 96582
SGTC_488 nitrendipine 139 µM 0.587279254361371 0.307279643883364 no 1051 0.278508085882624 1397 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2697 mebhydrolin 72.4 µM 0.584695669100639 0.308042871100352 no 1052 0.279376183335043 1419 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1778 st046819 58.9 µM 0.584191183346015 0.308192000318535 no 1053 0.279545846315822 1385 671715
SGTC_1754 st042065 16.137 µM 0.582114824570923 0.308806118443631 no 1054 0.280244670149991 1310 1126236 YIL048W NEO1
SGTC_3101 9120531 49.47 µM 0.580749276889599 0.309210293943844 no 1055 0.280704722671171 1419 24824904
SGTC_1159 4092-0538 61.2 µM 0.580640534972273 0.309242489368398 no 1056 0.280741373480962 1407 717301
SGTC_356 1634-0012 32.5 µM 0.580150450384577 0.309387607810877 no 1057 0.280906582259802 1380 735457
SGTC_927 2425-1185 123 µM 0.579460221125171 0.309592041310164 no 1058 0.281139339993327 1331 730375
SGTC_99 0109-0120 622.8 µM 0.577909587277182 0.310051525999805 no 1059 0.281662581093007 1426 759414
SGTC_2620 irigenin 100 µM 0.57643985316391 0.310487312439686 no 1060 0.282158956677032 1457 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2469 5655019 90.81 µM 0.574063655337548 0.311192434492994 no 1061 0.282962363292532 1474 2788239
SGTC_691 1548-0686 185 µM 0.571918164571476 0.311829691541632 no 1062 0.283688708683688 1330 46495133
SGTC_140 0062-0056 502.533 µM 0.571363556019439 0.31199451402946 no 1063 0.283876613845074 1319 3758964
SGTC_109 0132-0036 33.701 µM 0.571023935982263 0.312095463300685 no 1064 0.283991708833163 1289 67274 A color developer.
SGTC_2636 apigenin dimethyl ether 100 µM 0.569631549420905 0.312509486255966 no 1065 0.28446381271486 1392 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.569618232374099 0.312513447193157 no 1066 0.284468329814602 1373 229346 A bile salt which induces apoptosis.
SGTC_2674 ligustilide 100 µM 0.568723877030762 0.31277950807569 no 1067 0.284771770686719 1358 5319022 A signalling regulator.
SGTC_1208 2323-2347 50.3 µM 0.567671412245247 0.31309272974233 no 1068 0.285129053356618 1397 5412760
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.56430771192206 0.314094696852657 no 1069 0.286272366952007 1440 688801
SGTC_850 0388-0143 75.9 µM 0.563774401708019 0.314253683589249 no 1070 0.286453837536521 1370 67273
SGTC_216 k038-0035 28.382 µM 0.562645978206878 0.314590194960171 no 1071 0.286837988410882 1346 4444231 YPR107C YTH1
SGTC_1022 4477-0945 21.3 µM 0.560149532533242 0.315335216501748 no 1072 0.287688723543649 1378 4648966
SGTC_2919 7978188 46.38 µM 0.560065500672091 0.315360307464676 no 1073 0.287717380530365 1412 2980291
SGTC_2737 bleomycin 30.5 nM 0.559759329293457 0.315451733976795 no 1074 0.287821804110568 1403 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3122 9126309 49.47 µM 0.558788206532452 0.315741797829286 no 1075 0.288153136064155 1425 17591206
SGTC_1011 4112-3381 17.4 µM 0.557760663244031 0.316048837496724 no 1076 0.288503913641393 1440 2877139
SGTC_406 estrone 100 µM 0.557251577020965 0.316201004314824 no 1077 0.288677777456601 1492 5870 A steroid.
SGTC_3234 9132280 49.47 µM 0.556939858833262 0.316294192830545 no 1078 0.288784260225708 1384 17612295
SGTC_2698 st077697 67.5 µM 0.556084749232817 0.316549888735794 no 1079 0.289076460115418 1338 3154499
SGTC_2862 9027634 71.43 µM 0.553911128559521 0.317200241993998 no 1080 0.28981983430931 1340 5012562
SGTC_1641 st009299 47.1 µM 0.553173655324824 0.317421024460183 no 1081 0.290072252363166 1368 4046054
SGTC_2455 5377712 9.75 µM 0.551669859843814 0.317871427380073 no 1082 0.290587281777421 1356 2243908
SGTC_2064 5220758 200 µM 0.550170573040749 0.318320748301711 no 1083 0.291101192556339 1435 788518
SGTC_2199 6590217 200 µM 0.549706701845097 0.318459819953934 no 1084 0.29126027970012 1425 703109
SGTC_2339 9000433 200 µM 0.546043556200176 0.319558952674748 no 1085 0.29251799867273 1380 2988954
SGTC_2607 solasodine 47.35 µM 0.545296871379182 0.319783191676005 no 1086 0.292774677763111 1416 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2128 5255449 168.493 µM 0.543436980052053 0.320342027126349 no 1087 0.293414485057946 1389 736008
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.543275666864507 0.320390515600987 no 1088 0.293470007714219 1496 94937 An inhibitor of serotonin biosynthesis.
SGTC_2569 tetrandrine 100 µM 0.5431936309538 0.320415175617832 no 1089 0.293498245658391 1374 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.541922845638751 0.320797275247348 no 1090 0.293935828939717 1530 1273210
SGTC_2248 tofa 1.1 µM 0.539471246753639 0.321534958165195 no 1091 0.294780865876481 1446 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_277 nystatin 15.5 µM 0.538643014790379 0.321784331399535 no 1092 0.295066600478612 1399 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3186 9110464 49.47 µM 0.534985467990677 0.322886545073746 no 1093 0.296329953045189 1469 17018021
SGTC_2475 5812728 15.03 µM 0.533838150999235 0.323232614170273 no 1094 0.29672675800751 1402 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_579 4491-1009 110 µM 0.529804624274858 0.32445047351341 no 1095 0.298123699358721 1531 1271041
SGTC_1790 st045711 43.5 µM 0.5272992426503 0.325207881162788 no 1096 0.298992900057388 1564 585119
SGTC_2059 5238311 157 µM 0.524474859337129 0.32606259354829 no 1097 0.299974150730101 1414 703021
SGTC_2572 astragaloside iv 100 µM 0.522320919630598 0.326715031923086 no 1098 0.300723453037679 1471 45006101 An anti-inflammatory agent.
SGTC_1144 3486-0183 12.5 µM 0.52179887714456 0.326873240933363 no 1099 0.300905185781121 1445 6744069
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.521401552774719 0.326993674017408 no 1100 0.301043535001275 1402 6312947
SGTC_306 1672-3436 11.6 µM 0.520634507317982 0.327226224314467 no 1101 0.301310702986941 1480 6797378
SGTC_2067 5224629 34.075 µM 0.519954093757745 0.327432565990879 no 1102 0.301547785719623 1418 2835000
SGTC_3176 9106582 49.47 µM 0.51934614288818 0.327616977299336 no 1103 0.301759690580581 1402 17018027
SGTC_2303 7774051 200 µM 0.519237930253411 0.327649806128253 no 1104 0.301797415749745 1522 2953184
SGTC_702 1488-0190 94 µM 0.518425296539035 0.327896380092914 no 1105 0.302080784427303 1528 949357
SGTC_3154 9100113 49.47 µM 0.517611489475111 0.328143385290896 no 1106 0.302364681920785 1408 25237525
SGTC_3073 9114972 49.47 µM 0.516514210113834 0.328476548460463 no 1107 0.302747658379539 1517 41905075
SGTC_1664 st014217 9.02 µM 0.516206907928079 0.328569878033944 no 1108 0.302854953045005 1513 3982782
SGTC_3127 9126946 49.47 µM 0.514722831970377 0.329020751541104 no 1109 0.303373358148755 1404 27243249
SGTC_3064 1327-0027 10 µM 0.514585568179606 0.329062465902863 no 1110 0.303421326025286 1390 16000455 YPR107C YTH1
SGTC_2146 5545642 200 µM 0.511316690940712 0.330056503192074 no 1111 0.304564659712453 1462 825326
SGTC_1151 3909-8316 15.3 µM 0.511063864892932 0.330133435530032 no 1112 0.304653168815745 1469 800431
SGTC_247 mechlorethamine 29.705 µM 0.510898127843024 0.330183871489214 no 1113 0.304711196091542 1445 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_686 1319-0111 510 µM 0.510251155882903 0.33038078307451 no 1114 0.304937758666683 1548 4562600
SGTC_2827 7993847 71.43 µM 0.509541573414837 0.330596804731204 no 1115 0.305186332775039 1487 2985692
SGTC_1312 1218-2183 165 µM 0.509172699370236 0.330709125161496 no 1116 0.3053155887008 1471 6744073
SGTC_2137 5261020 140 µM 0.508983803385019 0.330766649013187 no 1117 0.305381788514814 1448 763655
SGTC_21 0849-0113 22.993 µM 0.508926747658164 0.330784024785544 no 1118 0.305401785313296 1433 1560156
SGTC_1610 st001799 48.1 µM 0.50835919887769 0.330956886149749 no 1119 0.305600730495837 1418 621897
SGTC_2180 6301957 200 µM 0.508307632100075 0.330972593905478 no 1120 0.305618809253812 1454 845462
SGTC_3341 9147222 25.867 µM 0.507925799101762 0.331088913309029 no 1121 0.305752690542204 1461 1939759
SGTC_265 mycophenolic acid 32.932 µM 0.505511479745193 0.331824774706043 no 1122 0.306599818777796 1530 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3356 9151811 4.48 µM 0.50444668420236 0.332149520682236 no 1123 0.306973759607719 1441 1859254 YPR165W RHO1
SGTC_2094 5332512 191.667 µM 0.503458941958896 0.332450879356161 no 1124 0.307320820065293 1571 755774
SGTC_1351 1496-0003 46.5 µM 0.503089872447186 0.332563509722681 no 1125 0.307450543388965 1518 3891978
SGTC_1795 st049545 62.3 µM 0.502243480375384 0.332821863529399 no 1126 0.307748130575132 1505 5291882
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.501746191479832 0.332973693669545 no 1127 0.307923033864229 1565 5024745
SGTC_1793 st048256 72.231 µM 0.501230416836811 0.333131196733257 no 1128 0.308104484952386 1429 672022
SGTC_3301 9125354 19.7965 µM 0.499547495064065 0.333645318294208 no 1129 0.308696868042328 1451 41905162
SGTC_2271 7849410 118.62 µM 0.499198178735044 0.333752071341556 no 1130 0.308819888756171 1494 972430
SGTC_1268 0828-0275 2.46 µM 0.499114093166773 0.333777770377282 no 1131 0.308849504852037 1523 745337
SGTC_1689 st020265 53.493 µM 0.498557175229264 0.3339480006451 no 1132 0.3090456903955 1558 5758320 YPR016C TIF6
SGTC_835 0312-0010 67.2 µM 0.49747155412273 0.334279935130838 no 1133 0.309428278829584 1457 1626196
SGTC_926 2268-1401 59.4 µM 0.494551151891409 0.33517350660843 no 1134 0.310458495278713 1450 2931578
SGTC_125 0133-0007 11.75 µM 0.493601143318465 0.335464387428601 no 1135 0.310793946591416 1610 26541
SGTC_500 h-89 112 µM 0.49284734620266 0.335695260942698 no 1136 0.311060226921325 1614 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2520 obtusaquinone 4.71 µM 0.49159747571375 0.336078208834002 no 1137 0.311501964142304 1575 5967872
SGTC_532 1548-0774 215 µM 0.489383248653511 0.336757043639925 no 1138 0.312285196635848 1605 5932993
SGTC_1049 3226-0134 66 µM 0.489004151248664 0.336873320240554 no 1139 0.312419378946315 1510 5702385
SGTC_2074 5212007 75.395 µM 0.488897083144579 0.336906162949742 no 1140 0.312457280428995 1541 758611
SGTC_1081 sertraline 6 µM 0.487347455364505 0.33738164415723 no 1141 0.313006061593669 1569 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_33 0986-0033 35.816 µM 0.487002592867759 0.337487495670562 no 1142 0.313128246740141 1480 2848082
SGTC_3203 9113543 49.47 µM 0.486843564026491 0.337536312048206 no 1143 0.313184597740967 1539 17018012
SGTC_1876 myriocin 605 nM 0.486713851052155 0.337576131488882 no 1144 0.313230564055293 1594 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1040 k898-0338 155 µM 0.48618898536699 0.337737273934791 no 1145 0.313416590038566 1651 20969351
SGTC_1529 apigenin 74 µM 0.484415656186267 0.338281935232319 no 1146 0.314045454749316 1586 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3244 9134489 49.47 µM 0.484247637179694 0.338333558258972 no 1147 0.314105066338303 1449 16584271
SGTC_672 1441-0018 53.7 µM 0.475969038603343 0.340880864285652 no 1148 0.317048217883453 1477 251141
SGTC_2713 st079149 53.4 µM 0.475042180031039 0.341166511325335 no 1149 0.317378454572148 1551 3103253
SGTC_159 3970-0959 50 µM 0.474913199271266 0.341206268916611 no 1150 0.317424421528934 1579 6615653
SGTC_1274 0865-0114 173 µM 0.474682139929049 0.341277496062216 no 1151 0.317506774918955 1527 870624
SGTC_1215 3852-0577 11.2 µM 0.470381885239892 0.34260413692733 no 1152 0.319041101948781 1636 2884876
SGTC_808 0711-0032 135 µM 0.470034826293902 0.342711290588867 no 1153 0.31916506805021 1648 4252555
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.469515823381131 0.34287155517322 no 1154 0.319350488607098 1472 4000243
SGTC_251 melphalan 456.522 µM 0.469300860956147 0.342937942397543 no 1155 0.31942729997239 1613 460612 A DNA alkylator.
SGTC_2003 4023581 200 µM 0.468453674713815 0.343199627616332 no 1156 0.319730095893982 1524 16641307
SGTC_1575 cyproterone acetate 48 µM 0.468132375483156 0.343298892601148 no 1157 0.319844964067823 1463 9880 An androgen receptor antagonist and liver toxin.
SGTC_2810 7959871 45.46 µM 0.467896908328474 0.343371646741803 no 1158 0.319929157258372 1608 2974535
SGTC_327 1273-0057 3.96 µM 0.467799298802873 0.343401807627353 no 1159 0.319964061055709 1503 3108138
SGTC_2842 9000675 19.48 µM 0.465610420255661 0.344078422442977 no 1160 0.320747191447383 1455 2989072
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.464947203045215 0.344283531421926 no 1161 0.320984633076291 1536 165521
SGTC_272 doxorubicin 8.13 µM 0.464024164530756 0.344569069921811 no 1162 0.321315216460571 1531 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_654 1124-0271 80.9 µM 0.463824555059041 0.34463083001811 no 1163 0.32138672460676 1491 5403748
SGTC_3145 9085516 49.47 µM 0.462977450557681 0.34489297414399 no 1164 0.321690265173274 1508 25236195
SGTC_3290 9121031 71.43 µM 0.460732252305294 0.345588130980345 no 1165 0.322495356285863 1506 17014854
SGTC_2110 5483698 200 µM 0.460319956814789 0.345715842338607 no 1166 0.322643289307817 1537 2848765 YHR062C RPP1
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.458963548103432 0.346136123089619 no 1167 0.323130171392896 1511 91467 include heat shock
SGTC_2443 5493264 126.67 µM 0.457918314947829 0.346460116030125 no 1168 0.323505564079335 1649 5340055
SGTC_3328 9140624 29.0385 µM 0.456563669584162 0.346880185231139 no 1169 0.323992348676024 1651 4904392
SGTC_1558 st069300 45.6 µM 0.455229472427966 0.347294097586765 no 1170 0.3244720796976 1625 24208000
SGTC_3040 9091894 49.47 µM 0.453731127558491 0.347759151215172 no 1171 0.325011179965047 1568 25236966
SGTC_563 tetrahydrosecaminediol 614 µM 0.450235891652449 0.348844886115784 no 1172 0.326270179501454 1654 334274 A psychoactive constituent of the cannabis plant.
SGTC_575 k072-0246 11.9 µM 0.449504023218354 0.34907238561631 no 1173 0.326534053239208 1579 6796779
SGTC_1378 2093-0007 380 nM 0.449351343458284 0.349119852586236 no 1174 0.326589112578571 1563 3618014
SGTC_1368 1852-0141 284 µM 0.447532724760595 0.349685428569003 no 1175 0.327245232620092 1547 2838987
SGTC_3241 9133421 49.47 µM 0.447068797921119 0.349829759616452 no 1176 0.327412693427845 1582 17018221
SGTC_558 k064-0027 21.3 µM 0.445350283415826 0.350364591058509 no 1177 0.328033317430673 1633 5088526
SGTC_2972 9093619 59.92 µM 0.445342316518448 0.350367071186824 no 1178 0.328036195702151 1491 25236256
SGTC_1788 fluconazole 20 µM 0.442338892923932 0.351302503169056 no 1179 0.329121995395369 1531 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3076 9116187 49.47 µM 0.440981088844972 0.35172569460097 no 1180 0.329613343897903 1678 27241210
SGTC_1961 st076550 68.7 µM 0.440271154212752 0.351947035557381 no 1181 0.329870365120295 1571 1579337
SGTC_3003 9075612 71.4286 µM 0.439938519967363 0.352050760376616 no 1182 0.329990818026107 1575 6501993
SGTC_533 1222-0222 6.71 µM 0.438761449949865 0.352417892650741 no 1183 0.330417197958623 1663 3982874
SGTC_179 1273-0063 6.77 µM 0.436687979241815 0.353064949829059 no 1184 0.331168824072915 1515 3108139
SGTC_2667 digitoxin 100 µM 0.436649347697754 0.353077009412899 no 1185 0.331182834346 1606 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_612 0302-0167 22.4 µM 0.436022684177192 0.353272655159109 no 1186 0.331410135689358 1661 235821
SGTC_2565 isoliquiritigenin 100 µM 0.435793040778847 0.3533443600524 no 1187 0.331493446747945 1484 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1248 0469-0687 58.6 µM 0.435030092329535 0.353582623893964 no 1188 0.331770292443949 1651 4017482
SGTC_2956 9076196 2.52 µM 0.43381152205084 0.353963294447252 no 1189 0.332212656962829 1589 16423868
SGTC_3024 9090631 49.47 µM 0.430887606434302 0.354877294700387 no 1190 0.333275047706316 1653 25236383
SGTC_1320 1313-0481 95.3 µM 0.42748193115354 0.355942944091791 no 1191 0.334514171522413 1677 6813365 YLR208W SEC13
SGTC_1154 4088-0362 150 µM 0.424901637787957 0.35675107878384 no 1192 0.335454190346077 1549 6618304
SGTC_1979 st071809 45.3 µM 0.424827560745288 0.356774288852408 no 1193 0.335481192379402 1656 4976333
SGTC_2201 6605497 169.863 µM 0.422959102482724 0.357359895649135 no 1194 0.33616255011703 1655 670741
SGTC_1131 3454-3128 32.3 µM 0.41897928384353 0.358608357755858 no 1195 0.337615636222363 1704 710982
SGTC_1762 st045503 25.4615 µM 0.418923446872694 0.358625884504856 no 1196 0.33763604035689 1585 4645554
SGTC_496 calpeptin 138 µM 0.416790687223408 0.359295562145351 no 1197 0.338415757390342 1553 73364 A calpain inhibitor.
SGTC_606 k015-0008 38.6 µM 0.416652088379986 0.35933909659203 no 1198 0.338466451861302 1712 1970475
SGTC_147 4466-0538 29.23 µM 0.415494399328001 0.359702802597567 no 1199 0.338890007146429 1645 6742687 YHR072W ERG7
SGTC_2030 5175110 200 µM 0.413047421982365 0.360471976452847 no 1200 0.339785934984444 1664 2831986
SGTC_1758 st042942 75.2445 µM 0.410684836983333 0.361215158895888 no 1201 0.340651823405758 1620 669317
SGTC_1278 0874-0585 172 µM 0.410551751640447 0.361257038274421 no 1202 0.340700624287083 1644 766306
SGTC_1221 2958-7315 257 µM 0.410539020372745 0.361261044644815 no 1203 0.340705292837878 1639 4562705
SGTC_273 hydroxyurea 18.1 mM 0.40999042301077 0.361433695808843 no 1204 0.34090648644325 1625 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2499 avocadenofuran 51.48 µM 0.408480152956349 0.361909144340074 no 1205 0.341460599303584 1539 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2622 2-methoxyxanthone 59.94 µM 0.408415235132259 0.3619295859224 no 1206 0.34148442510133 1761 71034 A hepatoprotective.
SGTC_1406 3909-7906 11.9 µM 0.407946463064881 0.362077206421496 no 1207 0.341656490100853 1643 X1406
SGTC_3174 9107204 49.47 µM 0.407539725320343 0.362205308386136 no 1208 0.341805811774293 1662 3938802
SGTC_1136 pergolide 1.05886 µM 0.407282686958235 0.362286270522392 no 1209 0.341900188534794 1614 47811 A dopamine receptor agonist.
SGTC_2327 6189656 200 µM 0.4067046493815 0.362468363732389 no 1210 0.34211246264463 1740 5349088
SGTC_519 k048-0011 62.8 µM 0.406395367154327 0.362565806501109 no 1211 0.342226061590331 1662 6836379
SGTC_1546 5-methoxyflavanone 78.7 µM 0.406211677802137 0.362623684067086 no 1212 0.342293537201524 1694 147795
SGTC_1871 st057448 67.3 µM 0.405017414744617 0.363000053682974 no 1213 0.34273235505865 1699 691747
SGTC_828 2074-0507 139 µM 0.404994545866729 0.363007262056777 no 1214 0.342740760031081 1720 X828
SGTC_2513 baicalein 25.65 µM 0.404363907045102 0.36320606138186 no 1215 0.342972568652367 1526 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_645 0845-0943 5.41 µM 0.403758166062868 0.363397046745289 no 1216 0.343195281055265 1614 1885106
SGTC_2097 5376186 200 µM 0.403563605000318 0.363458397524883 no 1217 0.343266826759838 1716 742755
SGTC_1567 st069303 68.4 µM 0.403214958634678 0.363568344656333 no 1218 0.343395048118615 1615 5581319
SGTC_1305 1181-0477 144 µM 0.402907806283022 0.363665215783561 no 1219 0.343508024197887 1720 6252086
SGTC_2437 5741531 144.16 µM 0.402698558017749 0.363731214459974 no 1220 0.343584997426621 1741 2262990
SGTC_477 mead ethanolamide 10 µM 0.402033532543449 0.363940995969753 no 1221 0.343829674086008 1602 16061185
SGTC_1697 st025554 27.742 µM 0.400519234135374 0.364418831715743 no 1222 0.344387059826435 1612 1269519
SGTC_2908 7930301 100 µM 0.400289374342418 0.364491382247565 no 1223 0.344471696628848 1539 2223178
SGTC_74 000s-0487 160.283 µM 0.400191638104923 0.364522232158504 no 1224 0.344507686503208 1523 677548
SGTC_1655 st012546 55.1 µM 0.39991135932261 0.364610705494956 no 1225 0.344610902683051 1620 720985 YLR208W SEC13
SGTC_2473 5854593 8.94 µM 0.399851601196464 0.36462956979223 no 1226 0.34463291085973 1619 2872951
SGTC_2372 9071633 200 µM 0.399509776075707 0.364737482598896 no 1227 0.344758810917479 1681 21321366
SGTC_2610 ononetin 44.17 µM 0.395921473608926 0.365870940448649 no 1228 0.346081479562164 1581 259632
SGTC_10 0279-0212 42.575 µM 0.394941837490679 0.366180587813695 no 1229 0.346442906361907 1601 39851 YBR002C RER2
SGTC_3258 9138477 49.47 µM 0.394081821487736 0.366452497024154 no 1230 0.346760315832638 1674 4970355
SGTC_962 1254-0300 21.5 µM 0.393956086055628 0.366492256117439 no 1231 0.346806730520249 1656 7340576
SGTC_1603 st002045 67.8 µM 0.392502910166663 0.366951872120614 no 1232 0.347343330758422 1727 5887985
SGTC_1074 carmofur 3.8 µM 0.39233370517633 0.367005401331675 no 1233 0.347405831370011 1652 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_512 prima-1 270 µM 0.389583645682204 0.367875764202054 no 1234 0.348422223675998 1701 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1700 st030840 7.9285 µM 0.388877253856014 0.368099439019075 no 1235 0.348683474604092 1764 5499307
SGTC_2669 eugenol 100 µM 0.388413467300477 0.368246318630162 no 1236 0.348855039790113 1734 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2450 5739737 12.93 µM 0.386972486075772 0.368702795231491 no 1237 0.349388288553192 1641 2262825
SGTC_3133 9127736 49.47 µM 0.386490444070903 0.368855538754123 no 1238 0.349566739205048 1805 27243420
SGTC_5 0352-0601 109.883 µM 0.382664950803858 0.37006844661584 no 1239 0.350984102572541 1674 762456
SGTC_3074 9116018 49.47 µM 0.38037649313714 0.370794642297639 no 1240 0.351832980686156 1676 17027303
SGTC_2859 9028643 45.46 µM 0.380325614277253 0.370810792915387 no 1241 0.351851862052265 1729 17151580
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.379059263160992 0.371212847534654 no 1242 0.352321928067538 1818 551469
SGTC_1172 0370-0043 85 µM 0.377710713242644 0.371641154081196 no 1243 0.35282275418094 1702 376585
SGTC_1009 4106-0057 9.87 µM 0.375557425980403 0.372325378779847 no 1244 0.353622973310769 1765 2928005
SGTC_3194 9111903 49.47 µM 0.375495568873386 0.372345040351564 no 1245 0.353645970646951 1702 17087251
SGTC_2124 5246320 200 µM 0.37516483138091 0.372450172460151 no 1246 0.35376894183322 1699 579342
SGTC_2263 7948595 193.29 µM 0.375097993613982 0.372471419453491 no 1247 0.353793794572331 1648 2971371
SGTC_2608 thymoquinone 42.66 µM 0.372454465050908 0.373312078838382 no 1248 0.354777254371903 1642 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.370464077071129 0.373945433668093 no 1249 0.355518368915352 1617 16623 A steroid.
SGTC_2645 abamectin 100 µM 0.370205188145181 0.374027838923008 no 1250 0.355614805603021 1738 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_254 nsc-64875 3.808 µM 0.36962452839087 0.374212685895617 no 1251 0.355831136230031 1797 56993
SGTC_2035 5154463 94.595 µM 0.368535622298847 0.374559405730146 no 1252 0.356236944277821 1755 2769623
SGTC_2857 9024691 58.44 µM 0.367005920720557 0.375046651068254 no 1253 0.356807300810256 1666 16478292
SGTC_108 0509-0257 621.132 µM 0.366457132530983 0.375221501461178 no 1254 0.357011997230633 1743 536624
SGTC_2085 5307070 144.047 µM 0.365334127128682 0.375579384122213 no 1255 0.357431003289719 1643 2840351
SGTC_441 propafenone 146 µM 0.363382707153953 0.376201522930051 no 1256 0.358159508938681 1653 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1084 voriconazole 435 nM 0.363325208343105 0.376219859209444 no 1257 0.358180982289812 1788 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_689 0833-0039 98 µM 0.360497593049284 0.377121925178607 no 1258 0.359237528134773 1784 5374726
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.36010010514341 0.377248785694787 no 1259 0.359386137081745 1796 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1028 k015-0029 4.8 µM 0.359921890861783 0.377305668094415 no 1260 0.359452773027763 1647 4588309
SGTC_1246 0422-0085 105 µM 0.359437611384691 0.377460253765774 no 1261 0.359633871126909 1812 264295
SGTC_1280 0880-0253 10.1 µM 0.357604843705109 0.378045464636294 no 1262 0.360319526483649 1677 6836607
SGTC_3307 9126885 69.2785 µM 0.357489408834874 0.378082332888699 no 1263 0.360362726806533 1622 24824909
SGTC_1874 staurosporine 7.6 µM 0.357311266516731 0.37813923118499 no 1264 0.360429398250574 1751 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1452 4194-0072 190 µM 0.356499322935405 0.378398597782895 no 1265 0.360733329524958 1836 1343545
SGTC_1662 st014054 52 µM 0.356376198721432 0.378437933269297 no 1266 0.360779425758423 1695 2838777
SGTC_1408 3909-7976 48.8 µM 0.356053491424496 0.378541037150745 no 1267 0.360900253108285 1722 24152374
SGTC_1501 4491-0275 38.4 µM 0.354449438601245 0.379053654733181 no 1268 0.361501044811929 1798 5104718
SGTC_2131 toluylene red 5.2905 µM 0.354106903653935 0.379163148452413 no 1269 0.361629384253313 1626 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1092 toremifene 6.32 µM 0.353987406189729 0.379201348943818 no 1270 0.361674160685039 1708 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2332 7982454 138.89 µM 0.353970301385679 0.379206817038543 no 1271 0.361680570114856 1690 2981748
SGTC_1815 st051655 58.2 µM 0.352585652833922 0.379649544069252 no 1272 0.36219954752968 1801 5984156
SGTC_3109 9122853 49.47 µM 0.349683699640665 0.380577924918789 no 1273 0.363288044048932 1743 1234709
SGTC_3042 9091578 49.47 µM 0.349640696799415 0.380591687397112 no 1274 0.363304182357009 1721 25236497
SGTC_1138 3761-0006 1.03 µM 0.349510891488894 0.380633230749389 no 1275 0.363352897774689 1729 12061087
SGTC_153 4077-0274 519.67 µM 0.348344020147782 0.381006742143465 no 1276 0.363790919106046 1840 3121976
SGTC_1919 st067113 52.3 µM 0.347064722281224 0.381416368307309 no 1277 0.364271347842714 1670 1268243
SGTC_2951 9072950 58.06 µM 0.346059463397472 0.381738341513539 no 1278 0.364649013451305 1766 16488155
SGTC_2176 5809774 33.9695 µM 0.343176018158404 0.38266233016282 no 1279 0.365733022565207 1844 2870539
SGTC_92 0063-0024 660.874 µM 0.342915365897632 0.38274588816545 no 1280 0.365831065792442 1787 3594437
SGTC_1440 4100-1550 40 µM 0.342160234049075 0.382987993629419 no 1281 0.36611515484134 1725 742806
SGTC_1746 st038117 42 µM 0.341801523713058 0.383103017028621 no 1282 0.366250131410371 1706 2898218
SGTC_2820 7989630 71.43 µM 0.339711106963813 0.383773530988939 no 1283 0.367037048268885 1863 2984098
SGTC_2592 piperlongumine 83.33 µM 0.338666768424642 0.38410863949926 no 1284 0.367430388846375 1647 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_815 1582-0027 36.9 µM 0.336766519837987 0.384718615514642 no 1285 0.368146456792525 1768 3128206
SGTC_338 4055-0136 114 µM 0.335871447441755 0.385006030971084 no 1286 0.368483904586037 1686 2900563
SGTC_1804 st050076 49.1 µM 0.333170969379628 0.385873560082677 no 1287 0.369502615272534 1768 3895976
SGTC_1565 sinapyl alcohol 95.1 µM 0.332232492311995 0.386175179968048 no 1288 0.369856855267003 1662 5280507 A phenol propionate derived from cinnamic acid.
SGTC_716 1683-5115 658 µM 0.327380015269593 0.387735825588407 no 1289 0.371690239955069 1829 723597
SGTC_1453 4237-0541 195 µM 0.324714002756095 0.388594038484142 no 1290 0.372698767904171 1867 739892
SGTC_1954 st077032 68.9 µM 0.323812302362234 0.388884427118068 no 1291 0.373040070836571 1652 698907
SGTC_2058 5236698 133 µM 0.323726835511197 0.388911954564406 no 1292 0.373072426099447 1730 766665
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.321816080044039 0.389527522379947 no 1293 0.373796015857253 1750 5379071
SGTC_3138 9097216 49.47 µM 0.320160834829263 0.390060999373704 no 1294 0.374423205535709 1864 25237486
SGTC_16 erodoxin 22.806 µM 0.318785157971002 0.390504530585814 no 1295 0.374944716890644 1764 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3096 9117468 49.47 µM 0.317605845270331 0.390884865625982 no 1296 0.375391969840002 1814 41316311
SGTC_308 4092-1169 104 µM 0.315618937937284 0.391525890463358 no 1297 0.376145880761956 1760 2268590 YDL196W YDL196W
SGTC_2782 7736369 71.43 µM 0.314925158632511 0.391749790113688 no 1298 0.376409239498966 1705 2950836 YOL077C BRX1
SGTC_1333 1482-0047 286 µM 0.314207930063806 0.391981295116547 no 1299 0.376681560076637 1860 3811116
SGTC_1853 st056710 91.2 µM 0.313947223981912 0.392065454568323 no 1300 0.37678056135391 1902 269167
SGTC_3332 9141069 11.198 µM 0.311863677782953 0.392738232614359 no 1301 0.37757206383768 1696 17332883
SGTC_1526 st051518 75 µM 0.311785355042228 0.392763529328947 no 1302 0.377601827319317 1742 673993
SGTC_476 mead acid 10 µM 0.310834778771371 0.393070582967123 no 1303 0.377963114391277 1766 5312531 An omega 9 fatty acid.
SGTC_3210 9128157 49.47 µM 0.307377999639888 0.394187745892565 no 1304 0.379277835955827 1668 17590849
SGTC_989 1501-0895 10.3 µM 0.307353827375061 0.394195560969982 no 1305 0.379287034364132 1907 2830112
SGTC_945 3381-0768 11.3 µM 0.306725646572662 0.39439867153938 no 1306 0.379526103499352 1870 1126236 YIL048W NEO1
SGTC_2818 7996756 12.99 µM 0.306600154503933 0.394439250506881 no 1307 0.379573868012361 1743 2241621
SGTC_1749 st037932 54.2 µM 0.306151976593427 0.394584182136586 no 1308 0.379744467492482 1747 594497
SGTC_1854 st056233 32.9 µM 0.305453621593835 0.394810045031104 no 1309 0.380010343839876 1903 5393174
SGTC_1613 st002381 52.1 µM 0.305019583198383 0.394950440122931 no 1310 0.380175618676867 1854 551167
SGTC_88 0180-0332 8.668 µM 0.304462578115018 0.395130630295233 no 1311 0.380387749305595 1788 3101745
SGTC_655 k060-0012 42 µM 0.303527617215489 0.395433138916154 no 1312 0.380743902027781 1751 5994525
SGTC_450 aminopyrene 156 nM 0.302497306650091 0.3957665711087 no 1313 0.381136493164669 1852 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1052 3253-3998 198 µM 0.301797160514395 0.395993198053381 no 1314 0.381403347794186 1761 5450317
SGTC_1493 4348-0038 111 µM 0.300383616257738 0.396450848488292 no 1315 0.381942279666635 1829 800424
SGTC_3031 9088762 49.47 µM 0.300037770096207 0.396562841724033 no 1316 0.38207417283818 1757 205253
SGTC_334 1502-1024 68.5 µM 0.299492519059014 0.396739424344611 no 1317 0.382282139584173 1794 3296216
SGTC_3190 9110366 49.47 µM 0.29763982491756 0.397339587810278 no 1318 0.382989037742845 1914 17123768
SGTC_433 pimozide 108 µM 0.297082587701899 0.397520147380156 no 1319 0.383201728792501 1652 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_569 4130-2812 160 µM 0.296892758408925 0.397581662099392 no 1320 0.383274192499016 1909 743552
SGTC_1968 st069590 43.6 µM 0.296563121047432 0.397688488069269 no 1321 0.383400034967324 1875 6384066
SGTC_250 brefeldin a 552.239 µM 0.295277205365217 0.398105289560669 no 1322 0.383891064055692 1791 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2924 9010168 62.78 µM 0.292204258903535 0.399101788265163 no 1323 0.385065227767145 1792 2993929
SGTC_1832 st054113 55 µM 0.291522977178647 0.399322804432981 no 1324 0.385325686693617 1911 1251267
SGTC_2887 9044784 58.44 µM 0.291145752486164 0.399445194647534 no 1325 0.385469924679695 1843 6465546
SGTC_3057 9095946 49.47 µM 0.29018073311578 0.39975833927351 no 1326 0.385838987563002 1823 24540043
SGTC_1171 0368-0077 21.4 µM 0.289955560990674 0.399831415943392 no 1327 0.385925117479224 1782 3239779
SGTC_2449 5812982 45.77 µM 0.289250234888723 0.400060343006098 no 1328 0.386194946035452 1803 776185
SGTC_86 0417-1630 471.922 µM 0.288377999603805 0.400343491128726 no 1329 0.386528703258057 1898 3634867
SGTC_1488 4013-0813 75.9 µM 0.287216789655933 0.400720528507236 no 1330 0.386973165694566 1788 2910057
SGTC_337 1315-0038 354 µM 0.28672060114368 0.400881665947217 no 1331 0.387163131077572 1794 1626437
SGTC_3100 9120536 49.47 µM 0.285452152098256 0.401293671943834 no 1332 0.387648878560721 1914 16421196
SGTC_2142 5622915 118.518 µM 0.284982611205141 0.401446211777862 no 1333 0.387828732014766 1792 5322196
SGTC_1012 4112-3522 18 µM 0.284932473407719 0.401462500941056 no 1334 0.387847938274034 1910 3112398
SGTC_3286 9117135 37.221 µM 0.284855462305476 0.401487521249037 no 1335 0.387877439410195 1730 3438150
SGTC_1463 k081-0032 34.1 µM 0.284024186378834 0.401757622019802 no 1336 0.388195922765793 1742 977755
SGTC_1683 st010134 710 nM 0.283745505856104 0.401848182277042 no 1337 0.388302709339769 1727 3818134
SGTC_303 1348-1668 34.2 µM 0.282149850136947 0.40236680924415 no 1338 0.388914305205874 1837 5380509
SGTC_503 tyrphostin 8 294 µM 0.281789761071196 0.402483870766034 no 1339 0.389052361203383 1915 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_991 3996-0057 64.7 µM 0.280376197267806 0.402943491330213 no 1340 0.389594448408868 1809 715343
SGTC_1319 1306-0155 43.7 µM 0.280288871706222 0.402971889660667 no 1341 0.389627943922995 1842 3122360
SGTC_2843 9000894 45.46 µM 0.278973134853012 0.403399830027684 no 1342 0.390132720941187 1806 2242070
SGTC_447 ml7 120 µM 0.278865443059107 0.403434861663731 no 1343 0.390174044669431 1905 4216 Selective myosin light chain kinase inhibitor.
SGTC_1560 lithocholic acid 53.1 µM 0.278087510480664 0.403687942485572 no 1344 0.390472591476995 1923 9903 A bile acid which acts as a detergent.
SGTC_206 4546-0025 72.014 µM 0.276619340058377 0.404165684652372 no 1345 0.391036206376817 1832 6620745 YIL048W NEO1
SGTC_1472 k841-0093 193 µM 0.275932522460479 0.404389223996061 no 1346 0.391299946966512 1908 X1472
SGTC_2730 imipramine 71.33 µM 0.27586771929266 0.404410317173236 no 1347 0.391324834213834 1918 3696 A tricyclic antidepressant.
SGTC_391 gliotoxin 8.33 µM 0.272321762003503 0.405564934334716 no 1348 0.392687312324154 1870 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1734 st037168 69.4 µM 0.271974626404681 0.405678011265175 no 1349 0.39282076469222 1775 708907
SGTC_665 3914-0008 307 µM 0.270310235909735 0.406220283712397 no 1350 0.393460795631085 1787 1069549
SGTC_2076 5212012 200 µM 0.268486217725084 0.40681477083549 no 1351 0.394162541112476 1858 604802
SGTC_920 mycophenolic acid 780.421 nM 0.267531408470715 0.407126049633979 no 1352 0.394530017349894 1794 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2886 9058944 51.95 µM 0.265434214501387 0.407809964683044 no 1353 0.395337490882219 1831 4949929
SGTC_697 0508-1955 564 µM 0.264061371238734 0.40825781435405 no 1354 0.39586631449405 1967 6243113
SGTC_1530 rhein 70.4 µM 0.260688708406227 0.409358554046627 no 1355 0.397166287221128 1902 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3206 9114350 49.47 µM 0.259605291701472 0.409712302104362 no 1356 0.39758412703234 1937 17087243
SGTC_737 1950-0117 57.9 µM 0.254570797108818 0.411357082752862 no 1357 0.399527308363775 1979 5393513
SGTC_2210 7115885 190.385 µM 0.253214451855108 0.411800471608729 no 1358 0.400051249692869 1887 2927039
SGTC_3151 9099821 49.47 µM 0.252776746555225 0.411943581406812 no 1359 0.40022036891546 1801 17174189
SGTC_1579 chlormadinone acetate 49.4 µM 0.251081023578785 0.412498116392077 no 1360 0.40087573352508 1989 45114258 A steroidal progestin.
SGTC_2686 alizarin 95.37 µM 0.2495753359841 0.412990652523431 no 1361 0.401457887064194 1808 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_938 3126-1755 342 µM 0.248817215006585 0.413238698748625 no 1362 0.401751087080705 2004 1777771
SGTC_1991 st073000 8.92 µM 0.248777919467939 0.413251556625861 no 1363 0.401766285969871 1947 4301969 YIL048W NEO1
SGTC_2589 lobaric acid 100 µM 0.244624538008453 0.414611104896161 no 1364 0.403373581313568 1804 73157 A novel microtubule depolymerizer.
SGTC_352 k048-0007 5.11 µM 0.24081196090525 0.41585999737543 no 1365 0.404850429462853 1950 6811911
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.240447207161561 0.41597952515187 no 1366 0.404991792683956 1856 6708760
SGTC_371 0195-0006 7.36 µM 0.239753756342182 0.416206786560453 no 1367 0.405260579254854 1825 3928593
SGTC_3279 9140807 49.47 µM 0.236250090800515 0.417355453445088 no 1368 0.406619306271926 1985 45595718
SGTC_2788 5282734 71.43 µM 0.236122909405089 0.41739716283911 no 1369 0.406668648674915 1977 743706
SGTC_1739 st037196 92.5 µM 0.235999975628274 0.417437480101511 no 1370 0.406716344543152 2020 612214
SGTC_1523 st012844 44.7 µM 0.235718191913331 0.417529896936048 no 1371 0.406825676258215 1883 4274103
SGTC_2831 7999036 19.48 µM 0.235310390928245 0.41766365182312 no 1372 0.40698391536818 2014 2988270
SGTC_1837 st055472 66.5 µM 0.234243681242395 0.418013567577309 no 1373 0.407397902720519 1925 676091
SGTC_552 k242-0005 476 µM 0.233349822522994 0.418306832544402 no 1374 0.407744886733027 1888 4088318
SGTC_1287 0971-0001 34.6 µM 0.231711378091932 0.41884450550734 no 1375 0.408381096718061 1917 4665869
SGTC_1759 st043059 70 µM 0.230317805917371 0.419301940408044 no 1376 0.408922412689268 1817 669426
SGTC_36 0335-0881 14.2 µM 0.230256697726211 0.41932200144648 no 1377 0.408946153398796 1904 23828853
SGTC_58 0957-0393 9 µM 0.230082974251007 0.419379033789307 no 1378 0.409013647297283 1876 6997992
SGTC_1063 disulfiram 1.84 µM 0.229437911648234 0.419590818665709 no 1379 0.409264286355832 1910 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3157 9099274 49.47 µM 0.22788833709991 0.42009966506494 no 1380 0.409866524916528 2026 17217662
SGTC_2740 felodipine 17.08 µM 0.227393897480424 0.42026205637822 no 1381 0.410058732558723 2023 3333 L-type calcium channel blocker
SGTC_2426 5582046 32.21 µM 0.225025983087569 0.421039950219423 no 1382 0.410979530498767 1950 2251934
SGTC_119 0121-0043 24.815 µM 0.223504435010678 0.42153996351388 no 1383 0.411571465894664 2019 1092378
SGTC_1914 st062367 72.6 µM 0.223455373549594 0.421556088271205 no 1384 0.411590555875863 1875 978205
SGTC_792 4534-1957 155 µM 0.222915186013029 0.421733637393713 no 1385 0.41180075850999 1918 1717904
SGTC_1615 st002656 86.5 µM 0.222029047028299 0.422024928463111 no 1386 0.412145635678498 1910 1584458
SGTC_2290 7904846 200 µM 0.221737735673092 0.422120697480499 no 1387 0.41225902622097 1865 2962154
SGTC_1923 st058458 19.1 µM 0.221544314564766 0.422184287485923 no 1388 0.412334317838959 2027 3534982
SGTC_414 piperonyl butoxide 100 µM 0.220339982901686 0.422580274629155 no 1389 0.412803191685517 1874 5794 A potent inhibitor of cytochrome P450.
SGTC_1198 1612-1005 86.7 µM 0.220081738501058 0.422665196210855 no 1390 0.41290374835845 1998 6998509
SGTC_3342 9147791 14.508 µM 0.219616404758413 0.422818226518115 no 1391 0.413084957080127 1941 1838168
SGTC_2880 9042983 58.44 µM 0.218252075304874 0.42326696887219 no 1392 0.413616356337757 1917 6464714
SGTC_928 2764-0428 58.7 µM 0.217571905457644 0.423490721137828 no 1393 0.413881338145334 1941 662578
SGTC_2310 7668677 200 µM 0.217411513948687 0.423543487973743 no 1394 0.413943829479966 1953 2197143
SGTC_947 3447-0010 211 µM 0.21729257084418 0.423582619679309 no 1395 0.413990173199245 1972 748350
SGTC_954 1189-0853 2.85 µM 0.216811759359691 0.42374081200731 no 1396 0.414177523645202 2008 2828194
SGTC_515 4092-1064 102 µM 0.215482463072766 0.424178229162318 no 1397 0.41469559168437 2050 717353
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.215479204591033 0.424179301510661 no 1398 0.414696861798589 1924 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1060 3448-7350 82 µM 0.214693440070938 0.424437908645253 no 1399 0.415003168696598 2017 570178
SGTC_230 MPP+ 141.667 µM 0.214386833471905 0.424538826401459 no 1400 0.415122704174962 1874 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_859 0439-0102 54.6 µM 0.214317586357408 0.424561619366374 no 1401 0.415149702356356 2056 610143
SGTC_1233 0325-0408 14.2 µM 0.214043334573614 0.424651892915996 no 1402 0.41525663203745 1987 12874
SGTC_1193 1488-0126 41.5 µM 0.209234426991619 0.426235445622041 no 1403 0.417132619153628 1915 1384710
SGTC_268 camptothecin 39.6153 µM 0.208569454731776 0.426454512378916 no 1404 0.417392178861426 1989 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2587 piperic acid 92.2 µM 0.203262877196101 0.428203505275854 no 1405 0.419464784762786 1904 5370536
SGTC_3172 9105863 49.47 µM 0.202075572702816 0.428595022947653 no 1406 0.419928822040185 2045 2348785
SGTC_1724 st037281 8.293 µM 0.20134394773932 0.428836313776336 no 1407 0.420214820398153 1900 574124 YDL195W SEC31
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.200544955769239 0.429099852711229 no 1408 0.420527201211982 1925 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_578 3460-0051 92 µM 0.200099853130603 0.429246678760719 no 1409 0.420701244113661 2072 2876744
SGTC_2394 5221648 200 µM 0.199427479887435 0.429468493143057 no 1410 0.420964183173897 2022 788586
SGTC_376 3970-0862 59.1 µM 0.198867116929252 0.429653372607947 no 1411 0.421183346305215 2058 3135186
SGTC_1651 st011928 86.1 µM 0.197526300051458 0.430095808273056 no 1412 0.421707851191935 1995 720198
SGTC_1307 1187-1599 12.2 µM 0.197163614924473 0.430215500301826 no 1413 0.421849751390638 1923 1538471
SGTC_2757 clomiphene 4.22 µM 0.196256626923829 0.430514849235134 no 1414 0.422204653931257 2082 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1400 3771-8998 51.5 µM 0.194853961147139 0.43097787385169 no 1415 0.422753638472288 2008 670767
SGTC_48 0382-0018 55 µM 0.194586465827517 0.431066185734735 no 1416 0.422858349616597 2078 762596
SGTC_1382 3002-2117 298 µM 0.194450302862069 0.431111140398112 no 1417 0.42291165275487 2074 1497314
SGTC_517 1365-0151 113 µM 0.193080701532206 0.431563368448672 no 1418 0.423447883108521 1965 768657
SGTC_1460 k062-0059 9.15 µM 0.192539293036276 0.431742160652393 no 1419 0.423659896126233 1933 1373085
SGTC_1402 3909-7673 35.9 µM 0.192161519545859 0.431866923083807 no 1420 0.423807843541144 2008 5328014
SGTC_1590 st077108 57.8 µM 0.191919819202948 0.431946749938457 no 1421 0.423902506270902 2071 5489485
SGTC_1943 st076331 65.2 µM 0.191767166813913 0.431997168179548 no 1422 0.423962295341146 2104 24208415
SGTC_1570 verbenone 133 µM 0.190887989257629 0.432287565686754 no 1423 0.424306675165921 2080 29025 A natural terpanoid with antifungal properties.
SGTC_1899 st063254 59.6 µM 0.190496791677869 0.432416792313847 no 1424 0.424459928513455 1898 3093813
SGTC_2753 fluvastatin 17.09 µM 0.189650237847768 0.432696464217215 no 1425 0.424791608715696 1983 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_940 3232-1287 54.8 µM 0.189287564846603 0.432816289071682 no 1426 0.424933720481944 2101 1585493 YIL048W NEO1
SGTC_1310 1188-0297 994 nM 0.188621291499495 0.433036437643107 no 1427 0.425194822075369 2009 1588352
SGTC_717 1532-0246 73.2 µM 0.187240382316548 0.433492780713916 no 1428 0.42573608208888 1961 9561992
SGTC_1806 st050005 60.3 µM 0.18480046477185 0.434299306087229 no 1429 0.426692771651547 1920 5194765
SGTC_900 1112-0045 141 µM 0.183225145943279 0.434820180124802 no 1430 0.427310682366133 2085 56211 YIL048W NEO1
SGTC_2847 9005661 71.43 µM 0.181499713959017 0.435390818390611 no 1431 0.427987678825301 2112 2991449
SGTC_347 4534-1311 26.2 µM 0.180874525302636 0.435597615290451 no 1432 0.428233032445896 2019 2862016
SGTC_621 3584-0052 32.1 µM 0.179522666474531 0.436044836800507 no 1433 0.428763660578261 2104 2273927
SGTC_1126 isoteolin 1.0172 µM 0.178989572086286 0.436221217433734 no 1434 0.42897294486981 1950 133323
SGTC_2914 7968218 45.32 µM 0.178780398044216 0.436290428625783 no 1435 0.429055068696407 2057 2977111
SGTC_1166 k206-0078 225 µM 0.177506773923132 0.436711885479755 no 1436 0.429555172451431 1986 5404595
SGTC_3088 9117578 49.47 µM 0.176388058409389 0.437082140584664 no 1437 0.429994542795435 2102 678341
SGTC_1037 k284-1091 78.7 µM 0.175467780688719 0.437386761160055 no 1438 0.430356042639753 2054 3334711
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.174853165460009 0.437590225262329 no 1439 0.430597505888765 1927 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3034 9090421 49.47 µM 0.174792056235594 0.437610455949505 no 1440 0.430621515226362 2104 17173761
SGTC_394 menadione 8.33 µM 0.173971327537554 0.437882180394828 no 1441 0.430943997946597 2103 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1787 fluconazole 80 µM 0.173703843878692 0.437970744433924 no 1442 0.431049108237339 2014 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3021 9087658 49.47 µM 0.173066945628746 0.438181634418895 no 1443 0.431299403209867 2117 25237042
SGTC_1397 3532-0190 20.1 µM 0.172458229073528 0.438383209280363 no 1444 0.431538648831269 2008 5322280
SGTC_1228 0124-0032 52.5 µM 0.172154760561566 0.438483708042271 no 1445 0.431657931322332 2075 X1228
SGTC_3261 9137475 49.47 µM 0.171772867009325 0.438610184227087 no 1446 0.431808048713378 2122 17027690
SGTC_416 estradiol valerate 100 µM 0.171684146841187 0.43863956762781 no 1447 0.431842924868613 1994 13791 A steroid.
SGTC_2362 9071156 126 µM 0.171551065343077 0.438683643775618 no 1448 0.431895240587227 2080 653133
SGTC_2506 ethyl hematommate 54.16 µM 0.171101333182797 0.438832599189315 no 1449 0.432072043801713 1910 3940691 An allergen.
SGTC_667 1498-1044 59 µM 0.170920205657424 0.438892592734316 no 1450 0.432143254315075 2001 6739982
SGTC_2002 4023503 131 µM 0.169710601797339 0.43929327689847 no 1451 0.432618867998777 2162 4736863 YCR052W RSC6
SGTC_2474 5321570 43.32 µM 0.168021776953871 0.439852808124709 no 1452 0.433283073547922 2093 2841384
SGTC_3008 9078912 71.4286 µM 0.165123078399368 0.440813466896434 no 1453 0.434423554203823 1996 16648731
SGTC_3331 9141060 1.957 µM 0.164630645209662 0.440976699140758 no 1454 0.434617354468112 1966 4906567 YPR165W RHO1
SGTC_2706 st078239 82.5 µM 0.164615478093027 0.440981726911024 no 1455 0.434623323834539 2115 15434492
SGTC_2157 5649910 96.377 µM 0.163762886584701 0.441264369023487 no 1456 0.434958904693627 1955 2858091
SGTC_2990 9074105 71.4286 µM 0.163683956204225 0.441290536702967 no 1457 0.434989974142696 2092 6502001
SGTC_1719 st032227 49.2 µM 0.163247902097862 0.441435105731573 no 1458 0.435161625810627 1975 3125804
SGTC_3316 9136639 10.545 µM 0.161677185352972 0.441955924442894 no 1459 0.435780035797839 2064 4903665
SGTC_3182 9108849 49.47 µM 0.160038528074733 0.442499377848728 no 1460 0.436425362165674 2032 17133045
SGTC_4 0960-0234 25.671 µM 0.15976292770374 0.4425907901462 no 1461 0.436533914155551 2017 6821112
SGTC_231 b-estradiol 524 µM 0.159237827693289 0.442764965995501 no 1462 0.436740750941981 1990 450 A steroid.
SGTC_1270 0831-1170 17.3 µM 0.158896921225024 0.4428780507095 no 1463 0.436875043192662 2107 6764716
SGTC_2181 6316240 54.2555 µM 0.156991528582279 0.44351018863428 no 1464 0.437625762263408 1993 12779990
SGTC_3163 9099914 49.47 µM 0.156852349240492 0.443556368782039 no 1465 0.437680607346985 2143 16268368
SGTC_910 3454-3003 490 µM 0.156388931588137 0.443710137753266 no 1466 0.437863230571859 2153 820824
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.156362459910762 0.443718921711465 no 1467 0.437873662907416 2036 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2120 5538279 151.968 µM 0.155871614837513 0.443881801269363 no 1468 0.438067109939158 2039 2058197
SGTC_1706 st031321 9.9705 µM 0.155436544943444 0.444026180598819 no 1469 0.438238587781144 2118 6103185
SGTC_638 3970-0837 4.09 µM 0.154057744196515 0.444483789004597 no 1470 0.438782102847123 1997 4118451 YLR208W SEC13
SGTC_1183 1254-0324 198 µM 0.152261136272885 0.445080173855575 no 1471 0.439490488113701 2086 5799357
SGTC_166 k072-0058 166.424 µM 0.150979635579919 0.44550564466475 no 1472 0.439995890095289 2172 5846229
SGTC_2277 7947813 106.88 µM 0.149707479605825 0.445928075024265 no 1473 0.440497703409136 2133 1246798
SGTC_341 1486-1430 230 µM 0.148442256785287 0.446348264057118 no 1474 0.440996876680051 2060 2054753 YPL210C SRP72
SGTC_1234 0326-0494 15.5 µM 0.148054999300804 0.446476886944928 no 1475 0.441149681655677 2126 1547813
SGTC_2853 9015042 58.44 µM 0.147117143825753 0.446788407600398 no 1476 0.441519779148871 2081 6457456
SGTC_1779 st039427 55 µM 0.146375026747949 0.447034934533886 no 1477 0.44181267036237 2183 1124498
SGTC_2344 7990960 76.95 µM 0.146224005979021 0.447085105255551 no 1478 0.441872277603464 2031 140813
SGTC_1999 st074831 12.5 µM 0.143749920194585 0.447907143121813 no 1479 0.442848974958236 2018 17112523
SGTC_1721 st082152 9.2685 µM 0.143498117411138 0.447990819529059 no 1480 0.442948398975869 2142 5296051
SGTC_169 k015-0017 16.025 µM 0.142176248814444 0.448430126638824 no 1481 0.443470395945807 2130 1840002
SGTC_2185 6113692 200 µM 0.142036467812084 0.448476584878588 no 1482 0.443525600269969 2043 874150
SGTC_838 0109-0203 71.4 µM 0.141008230313416 0.448818356172621 no 1483 0.443931720230459 2137 759422
SGTC_335 4077-0256 27.6 µM 0.140983734243876 0.448826498776577 no 1484 0.443941396091302 2134 3121989
SGTC_1443 4112-3303 14 µM 0.140801436831193 0.448887095935295 no 1485 0.444013403973936 2092 704433
SGTC_3184 9108758 49.47 µM 0.14012808946687 0.449110932459947 no 1486 0.44427939368107 2127 902885
SGTC_2380 9035439 200 µM 0.135422043571367 0.450675781221399 no 1487 0.446139098210306 2132 6462575
SGTC_2280 7785178 200 µM 0.134807960510972 0.450880032481033 no 1488 0.446381855859194 2073 2954328
SGTC_1867 st057372 64 µM 0.133767929825067 0.451225988581276 no 1489 0.446793043761731 2164 688837
SGTC_963 1269-2853 151 µM 0.133500298179055 0.451315019651782 no 1490 0.446898864234544 2038 3668223
SGTC_3169 9102970 49.47 µM 0.131986355107398 0.451818698049398 no 1491 0.447497542185828 2183 17027839
SGTC_275 trichlorophene 5.69 µM 0.131510658918148 0.451976974937192 no 1492 0.44768567760449 2086 62616
SGTC_801 0866-0028 10.1 µM 0.12949569112081 0.452647493141954 no 1493 0.448482717116867 2039 6849771
SGTC_2683 piperine 63.03 µM 0.125616338560979 0.45393879891129 no 1494 0.450017814552747 2103 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2662 daunorubicin 22.37 µM 0.125178241263941 0.454084657603188 no 1495 0.450191221346602 2158 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_648 0375-0473 33.3 µM 0.125049849408777 0.454127405144881 no 1496 0.450242042956707 2099 1713139
SGTC_2313 7726885 200 µM 0.123006865932187 0.454807679286629 no 1497 0.451050830515899 2097 726423
SGTC_1770 st043884 66.3 µM 0.1228819622201 0.454849274136812 no 1498 0.451100284713431 2193 670149
SGTC_2716 st080858 38.6235 µM 0.122518495001959 0.454970317105039 no 1499 0.451244199720596 2194 5296050
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.121126690769976 0.455433858581652 no 1500 0.451795344321481 2108 6708561
SGTC_1636 st007707 68.9 µM 0.114274610888689 0.457716821887091 no 1501 0.454510054106506 2172 403051
SGTC_1727 st034309 9.9045 µM 0.113427265456181 0.457999237378719 no 1502 0.454845912244113 2211 870305
SGTC_1360 1598-0022 39.8 µM 0.113403840338473 0.458007045141268 no 1503 0.454855197602346 2171 761525
SGTC_432 NS 1619 61.3 µM 0.111454267420872 0.458656908517731 no 1504 0.45562806444657 2080 4552 A K+/calcium channel activator.
SGTC_882 0843-0131 351 µM 0.110015423930214 0.459136598225265 no 1505 0.456198571319804 2219 5425421
SGTC_1157 4092-0394 27.6 µM 0.10840838787738 0.45967243122249 no 1506 0.456835873893425 2184 3659885
SGTC_1336 1486-0901 104 µM 0.108277396901632 0.459716110701436 no 1507 0.456887825924231 2132 5006114
SGTC_880 0833-0487 87.2 µM 0.107666816440976 0.459919717671024 no 1508 0.457129996550051 2207 76075
SGTC_3144 9087057 49.47 µM 0.106989983175834 0.460145429887212 no 1509 0.457398463204149 2250 17249618
SGTC_1648 st011736 69.8 µM 0.106005088424656 0.460473898217154 no 1510 0.457789157478903 2187 2855514
SGTC_1252 0493-0875 34.8 µM 0.104262088214829 0.461055265250189 no 1511 0.458480681557843 2174 3960963
SGTC_847 0342-0274 5.54 µM 0.103384958457638 0.461347858066301 no 1512 0.458828724792738 2197 18097
SGTC_2627 acetyl isogambogic acid 100 µM 0.103005918029387 0.461474304800754 no 1513 0.458979137016297 2108 6857789 A caspase activator and apoptosis inducer.
SGTC_3065 9113888 49.47 µM 0.101535613170988 0.461964830770492 no 1514 0.4595626442028 2194 16648368
SGTC_1031 k035-0009 16 µM 0.099446539847547 0.462661890810523 no 1515 0.460391866208998 2213 5180959
SGTC_2398 5228213 48.84 µM 0.0983842915669457 0.463016374772584 no 1516 0.460813573837667 2247 80771 YMR134W ERG29
SGTC_725 1497-0963 19 µM 0.0974985291226051 0.463311985933656 no 1517 0.46116525112848 2231 3549977
SGTC_1606 st000094 49.2 µM 0.0974873248919252 0.46331572532326 no 1518 0.461169699777583 2244 1242210
SGTC_386 1509-0011 3.07 µM 0.0971801545268626 0.463418244080274 no 1519 0.461291663917105 2193 3107280
SGTC_1362 1611-0397 101 µM 0.0968561293358586 0.463526390803884 no 1520 0.461420324328732 2191 27816
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0968467937396083 0.46352950669466 no 1521 0.461424031266037 2178 6708514
SGTC_1355 1499-0035 1.68 µM 0.0960857803587485 0.463783513465712 no 1522 0.461726222339709 2181 1548538
SGTC_2423 st077119 87.2 µM 0.0956318832602616 0.463935019724747 no 1523 0.461906471031341 2221 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1103 duloxetine 36.1 µM 0.0955307933243392 0.463968763235453 no 1524 0.461946616282084 2208 60835 A selective serotonin reuptake inhibitor.
SGTC_2420 aureobasidin a 50 nM 0.0949504317313695 0.464162491163941 no 1525 0.462177099352193 2219 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_478 N-arachidonylglycine 10 µM 0.0936744528445836 0.464588449827914 no 1526 0.462683882349384 2245 5283389
SGTC_1412 3909-8563 178 µM 0.0933174704466671 0.464707628165984 no 1527 0.462825676617238 2253 23767530
SGTC_992 3909-8734 162 µM 0.0928296619096893 0.464870487841517 no 1528 0.463019442976431 2163 4288319
SGTC_736 0958-0254 92.6 µM 0.0922532752274986 0.465062927784425 no 1529 0.463248405479955 2181 6812352
SGTC_1445 4239-0156 97.7 µM 0.0919012649661918 0.465180458523603 no 1530 0.463388243209607 2237 4008346
SGTC_1691 st019933 84.6 µM 0.0916713470762937 0.465257226163704 no 1531 0.463479581614698 2257 6176082
SGTC_2833 9001315 45.46 µM 0.0907746194315068 0.465556648274726 no 1532 0.463835838765635 2086 2989378
SGTC_2458 5808907 16.39 µM 0.089840459229291 0.46586859005094 no 1533 0.464206998177217 2246 2731747
SGTC_1981 st071826 47 µM 0.0891817203422532 0.466088573697089 no 1534 0.464468746269447 2148 11838600
SGTC_3223 9129970 49.47 µM 0.0889884772201853 0.466153108559427 no 1535 0.46454553381685 2227 17248386
SGTC_2646 retinol 96.75 µM 0.0884150475520326 0.466344614551502 no 1536 0.464773400957976 2223 445354 A vitamin A analog and teratogen.
SGTC_627 1391-0720 175 µM 0.0883914583982919 0.466352492693155 no 1537 0.464782774967527 2171 997839
SGTC_2292 7671323 168.05 µM 0.0881698707836199 0.466426497628143 no 1538 0.464870831831714 2147 937504
SGTC_1633 st005664 67.9 µM 0.0873142945703599 0.466712250381128 no 1539 0.465210845995717 2221 2063822
SGTC_2186 6124449 200 µM 0.0868978913622623 0.466851330547499 no 1540 0.465376337815282 2216 3834182 YLR033W RSC58
SGTC_2806 7952793 58.44 µM 0.0850069473087439 0.467482963323099 no 1541 0.466127933775246 2198 2972490
SGTC_1892 st058411 7.36 µM 0.0848668645229547 0.467529758507558 no 1542 0.466183617499576 2250 3934738
SGTC_3006 9075424 71.4286 µM 0.0846588121305613 0.46759926002417 no 1543 0.466266320760343 2172 7465181
SGTC_2296 7971656 126.45 µM 0.0846410031921843 0.467605209284193 no 1544 0.466273400089494 2179 666570
SGTC_2371 9071574 200 µM 0.0841051423590586 0.4677842225152 no 1545 0.466486418060885 2254 45596039
SGTC_820 1582-0060 59.9 µM 0.0837544154643587 0.467901392202297 no 1546 0.466625845902168 2168 3848840
SGTC_1912 st060209 90.8 µM 0.0824660179343265 0.468331839604455 no 1547 0.467138070012325 2160 688787
SGTC_906 1165-0455 526 µM 0.0816245307688267 0.46861299642869 no 1548 0.467472646824345 2272 3252859
SGTC_1828 st055811 49 µM 0.0814396595592414 0.468674767508959 no 1549 0.467546155037409 2273 5877589
SGTC_2702 st077768 96.8 µM 0.0803678833234031 0.469032895280204 no 1550 0.467972334824962 2185 6484119
SGTC_2323 6148992 148.28 µM 0.0800354173710807 0.469143991942402 no 1551 0.468104543661276 2175 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_276 colchicine 750 µM 0.0799251094072096 0.469180852929605 no 1552 0.468148409645399 2172 2833 A microtubule depolymerizer.
SGTC_2597 laccaic acid a 100 µM 0.0799225984086208 0.46918169201885 no 1553 0.468149408194526 2194 5491415 A textile dye.
SGTC_1972 st070201 17.4 µM 0.0797076781066867 0.469253511488407 no 1554 0.468234876320214 2264 2829099
SGTC_2440 5628896 157.78 µM 0.0797012963122406 0.469255644094668 no 1555 0.468237414213655 2204 5522048
SGTC_2985 9022375 71.43 µM 0.0792567398003768 0.469404203851668 no 1556 0.468414207324588 2177 4939335
SGTC_75 0159-0059 199.013 µM 0.078996331345533 0.469491227876312 no 1557 0.468517770553978 2256 5377270
SGTC_1419 3993-2473 62.6 µM 0.0755345248929637 0.470648240879809 no 1558 0.469894714547631 2217 704026
SGTC_2928 9011484 9.79 µM 0.0751090381243358 0.470790465355741 no 1559 0.470063978378221 2196 2994751
SGTC_1638 st008370 60.6 µM 0.0745648069627403 0.470972387114645 no 1560 0.470280488058281 2290 24207134
SGTC_1866 st057638 64 µM 0.0728862121769091 0.471533533945534 no 1561 0.470948332924277 2213 688802
SGTC_199 4063-0024 41.6 µM 0.0694691125406658 0.472676028725843 no 1562 0.472308108930148 2263 306215
SGTC_2357 9067248 200 µM 0.0676131031667446 0.473296673505951 no 1563 0.473046812225945 2205 9150235
SGTC_2196 6573537 42.6665 µM 0.0675839892835409 0.473306409634287 no 1564 0.473058400478005 2288 2903087
SGTC_2803 7707263 71.43 µM 0.066408173722845 0.473699633625163 no 1565 0.473526431440073 2236 2199229
SGTC_443 clozapine 122 µM 0.0659492003646012 0.473853133496543 no 1566 0.473709134792777 2296 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_60 0986-0278 202 µM 0.0656553480954479 0.473951412015197 no 1567 0.473826111361655 2155 3110598
SGTC_2095 5432005 200 µM 0.0648790407978653 0.474211054616772 no 1568 0.474135154224594 2273 783734
SGTC_2832 7992762 51.95 µM 0.0642975975506 0.474405530454606 no 1569 0.474366633187713 2177 2985177
SGTC_662 k832-1615 104 µM 0.0641364483937004 0.474459431237236 no 1570 0.474430789977587 2239 5878478
SGTC_2902 5787006 60.46 µM 0.0638317356735752 0.474561352092373 no 1571 0.474552104182222 2252 591003
SGTC_208 k072-0098 12.366 µM 0.0632884034123998 0.474743090964731 no 1572 0.474768424993922 2310 5948901
SGTC_1165 k072-0275 30.3 µM 0.0626663058179944 0.474951182456277 no 1573 0.475016114349308 2287 6153523 YGL055W OLE1
SGTC_1763 st044482 94.5 µM 0.0623755726069096 0.475048434989955 no 1574 0.475131873653975 2267 88505
SGTC_3268 9137683 49.47 µM 0.0615686550324771 0.475318363002875 no 1575 0.475453169614297 2248 1953228
SGTC_2179 6298986 200 µM 0.0608585139602696 0.475555926962797 no 1576 0.475735944616992 2301 738374
SGTC_2270 7924575 90.91 µM 0.0608524867685535 0.475557943280515 no 1577 0.475738344670313 2313 1262135
SGTC_1504 k297-0033 30 µM 0.0562333317314867 0.477103401039808 no 1578 0.477577964140705 2293 4388117
SGTC_2875 9039966 71.43 µM 0.0558019965265103 0.477247733327697 no 1579 0.477749772213048 2263 6463691
SGTC_1479 0549-0158 134 µM 0.0557868323752899 0.477252807571781 no 1580 0.477755812425154 2299 5440202
SGTC_1893 st059353 36.1 µM 0.0519560890429246 0.478534770834974 no 1581 0.479281840996789 2168 3112488
SGTC_2119 5528445 120.635 µM 0.050893310340407 0.47889047104152 no 1582 0.479705268089304 2278 791935
SGTC_2839 9003951 25.97 µM 0.0508532970120826 0.478903863387496 no 1583 0.479721210454235 2356 2990634
SGTC_2575 plumbagin 510 nM 0.0505559676950727 0.479003379400307 no 1584 0.479839675307452 2296 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1282 0886-0010 32.4 µM 0.0497826852564296 0.479262202861009 no 1585 0.480147782368386 2314 2836211 YNL267W PIK1
SGTC_2406 ethylparaben 405.7 µM 0.0487926357348287 0.479593592648695 no 1586 0.480542275509166 2179 8434 A possible steroid mimic.
SGTC_1769 st044406 64.4 µM 0.0474591201370027 0.480039969797637 no 1587 0.481073655502303 2269 670903
SGTC_2790 5423970 71.43 µM 0.0473004344605717 0.480093089458899 no 1588 0.481136890911219 2298 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1201 1889-3372 45.9 µM 0.0462840307180385 0.480433336592447 no 1589 0.481541933654667 2235 5392199
SGTC_2425 5628681 7.85 µM 0.0433063253630844 0.48143022212658 no 1590 0.482728674521996 2301 5714958
SGTC_1256 0570-0116 285 µM 0.042832157314739 0.481588976472292 no 1591 0.482917664836722 2286 410638
SGTC_397 arbidol 50 µM 0.0420082951651779 0.481864817458177 no 1592 0.483246042685208 2316 131410 A RNA synthesis inhibitor.
SGTC_3061 glucosamine 200 µM 0.0388981713268735 0.482906209140421 no 1593 0.48448578726848 2332 91431 and experimental redox chemotherapeutic
SGTC_3009 9080819 71.4286 µM 0.0373169096357721 0.48343572286538 no 1594 0.485116161471735 2294 17027216
SGTC_3103 9120822 49.47 µM 0.0362889224062655 0.483779978482504 no 1595 0.485525991381253 2349 17141819
SGTC_141 0443-0274 32.331 µM 0.0360526327141003 0.48385910964091 no 1596 0.485620195684571 2336 1627241
SGTC_2544 sphondin 68.51 µM 0.0354596707217927 0.484057689734545 no 1597 0.485856602119104 2331 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_39 0986-0283 58.349 µM 0.0336709792053516 0.484656737598117 no 1598 0.486569760542137 2335 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1852 st056254 31.4 µM 0.0333738148621159 0.484756263832182 no 1599 0.486688245370011 2272 442583
SGTC_1211 1056-0033 32.3 µM 0.0331754663583907 0.484822695210032 no 1600 0.486767331180179 2351 6741922
SGTC_925 2064-1272 59.6 µM 0.0328984060320648 0.484915489653495 no 1601 0.486877801955702 2292 6815817
SGTC_495 decylubiquinone 155 µM 0.0327533345355019 0.484964078057812 no 1602 0.486935645936378 2238 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2957 9076800 11.52 µM 0.0326711736402478 0.484991596083503 no 1603 0.486968405858533 2324 16459615
SGTC_1733 st037357 54.9 µM 0.0320048386549041 0.485214773291965 no 1604 0.487234096093523 2358 1272339 YGL099W LSG1
SGTC_2978 9011784 42.97 µM 0.0319050026628108 0.485248212005939 no 1605 0.487273904562118 2340 2994934
SGTC_844 0330-0132 15.3 µM 0.0312642102725682 0.48546283920156 no 1606 0.487529416255767 2342 2828079
SGTC_2531 methyl deoxycholate 70.07 µM 0.0305798230532536 0.485692072711635 no 1607 0.487802316747418 2327 16667744 Haematoxylin.
SGTC_3130 9127414 49.47 µM 0.0305290249866033 0.485709087565853 no 1608 0.487822572786514 2361 1494646
SGTC_1315 1237-0019 3.69 µM 0.0292086358907787 0.486151362016696 no 1609 0.48834909686435 2350 825140
SGTC_643 k048-0106 28.4 µM 0.0292049641979662 0.486152591902357 no 1610 0.488350561033225 2337 6763920
SGTC_977 1348-1378 135 µM 0.0291882141370295 0.486158202574857 no 1611 0.488357240493203 2358 X977
SGTC_589 1227-0070 34.1 µM 0.0289661930644348 0.486232571967298 no 1612 0.488445776650165 2330 2841384
SGTC_2204 7233102 200 µM 0.0288211193894591 0.486281166897515 no 1613 0.48850362851917 2342 2172480
SGTC_986 1493-0483 84 µM 0.0283659430832643 0.486433637372849 no 1614 0.488685143373645 2353 40079
SGTC_2600 tangeritin 87.95 µM 0.027660914757476 0.486669804723273 no 1615 0.488966298635611 2359 68077 A bioactive flavone.
SGTC_541 4513-1321 94 µM 0.0269305788623308 0.486914454422984 no 1616 0.489257551976111 2321 747515
SGTC_2994 9053520 71.4286 µM 0.0266931403669934 0.486993993214605 no 1617 0.489352242189304 2356 4647384
SGTC_454 lyso-paf C-16 6.67 µM 0.0265652190958967 0.487036845382605 no 1618 0.48940325730192 2328 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1324 1418-0026 34.4 µM 0.0254385733474745 0.487414265277381 no 1619 0.489852571986052 2286 1372513
SGTC_198 3454-2873 16.191 µM 0.0253298667829669 0.487450681957652 no 1620 0.489895925660863 2338 710957
SGTC_1583 clindamycin 39.6 µM 0.023999972681951 0.487896204629443 no 1621 0.490426315249156 2326 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_899 1083-0020 478 µM 0.0234448495268171 0.488082178787957 no 1622 0.490647715038287 2362 767123
SGTC_1380 2291-0730 164 µM 0.0221765575988348 0.488507084295522 no 1623 0.491153558658886 2344 2999191
SGTC_3325 9138760 55.175 µM 0.0220025905494596 0.488565368086385 no 1624 0.491222944539731 2358 43844959
SGTC_3105 9121040 49.47 µM 0.0211971496275067 0.488835216317166 no 1625 0.491544194020263 2382 41448907
SGTC_200 k038-0079 37.545 µM 0.020367333262808 0.489113236437683 no 1626 0.491875171361083 2330 3436683
SGTC_2226 7298446 200 µM 0.0197660599387285 0.489314689238911 no 1627 0.492114996418208 2374 3283010
SGTC_1426 4048-4480 71.7 µM 0.0190945305850184 0.489539684095852 no 1628 0.492382847298404 2374 14224343
SGTC_52 0329-0193 875 nM 0.0177359326061794 0.489994890323187 no 1629 0.492924757538265 2359 3739292
SGTC_3171 9103192 49.47 µM 0.0175263914173959 0.490065099503291 no 1630 0.493008339385756 2374 13018434
SGTC_719 2810-4230 27.3 µM 0.0168528926067783 0.490290765083122 no 1631 0.493276986838619 2380 721079
SGTC_1747 st037496 66.6 µM 0.0145942653799985 0.491047573286114 no 1632 0.494177937165286 2377 723305
SGTC_2400 5203494 178.7 µM 0.0120719010443765 0.491892791016588 no 1633 0.49518412523907 2396 6777674
SGTC_536 3852-0578 10.6 µM 0.00988802397202465 0.492624614768673 no 1634 0.496055313448693 2388 2869208
SGTC_1238 0333-0287 48.8 µM 0.00954510397774897 0.492739530604471 no 1635 0.496192112274683 2386 7226
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.00824989012605088 0.493173574759346 no 1636 0.496708807353566 2391 390807
SGTC_2949 9072542 2.23 µM 0.00772215453234094 0.493350428634683 no 1637 0.496919336678803 2382 16457352
SGTC_1434 4073-0095 163 µM 0.0070370914686022 0.493580007774815 no 1638 0.49719262985261 2391 24133745
SGTC_2517 totarol 10 µM 0.00699950584413571 0.493592603575746 no 1639 0.497207623978061 2379 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2762 leflunomide 42.06 µM 0.00682633873535604 0.493650635910052 no 1640 0.497276706008559 2397 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_497 capsazepine 133 µM 0.00673793348495138 0.493680262621889 no 1641 0.497311973789621 2389 2733484 A calcium channel blocker.
SGTC_878 0828-0289 13.7 µM 0.00667012104284973 0.493702988215236 no 1642 0.497339026431974 2393 745350 YLR208W SEC13
SGTC_1217 1183-1422 255 µM 0.00644627083095645 0.493778005992793 no 1643 0.497428327825344 2389 2849664
SGTC_3062 9077494 49.47 µM 0.00636294643296675 0.493805930128814 no 1644 0.497461568768919 2371 16459633
SGTC_2888 9058547 12.99 µM 0.00616390762653437 0.493872633244023 no 1645 0.497540972206581 2394 16476514
SGTC_2118 5526350 200 µM 0.00548186142888899 0.494101206069935 no 1646 0.497813064653914 2387 743594
SGTC_3320 9137005 35.139 µM 0.00546557676575963 0.494106663541632 no 1647 0.497819561197235 2389 4908713
SGTC_1191 1487-1166 10.6 µM 0.00464122968879272 0.494382928019127 no 1648 0.498148423891559 2389 3955771
SGTC_2161 5662504 8.5105 µM 0.00455640180338484 0.49441135665067 no 1649 0.498182264963739 2393 2859334
SGTC_3353 9151644 39.2805 µM 0.00453782115490872 0.494417583644644 no 1650 0.498189677493382 2390 4909158
SGTC_2923 7992654 58.14 µM 0.0036245029356425 0.494723668636838 no 1651 0.498554035699478 2402 2985126
SGTC_892 0929-0076 29 µM 0.00329348273641837 0.494834605900616 no 1652 0.498686092862002 2401 5751038
SGTC_3118 9124250 49.47 µM 0.00323296511003634 0.494854887666738 no 1653 0.498710235773327 2388 1504786
SGTC_2981 9013952 38.96 µM 0.00302259624763268 0.494925390403924 no 1654 0.498794160396346 2395 2996344
SGTC_2898 9056270 58.44 µM 0.00277958186504938 0.495006834113938 no 1655 0.498891108700091 2399 19154699
SGTC_317 4495-0002 170 µM 0.00197012791759125 0.495278115558452 no 1656 0.499214033184316 2403 15991618
SGTC_3228 9131799 49.47 µM 0.000676015202474417 0.495711830654389 no 1657 0.49973030897408 2404 17015818
SGTC_1271 0832-2808 169 µM 0 0.495938395655422 no 1658 0.5 2406 3663794
SGTC_2460 5552655 174.22 µM -0.000597177940630109 0.496138539614561 no 1659 0.49976176048472 2410 5401989
SGTC_456 gingerol 170 µM -0.000850794895805377 0.496223539537366 no 1660 0.499660581985062 2411 442793 A herb.
SGTC_2470 5664817 21.68 µM -0.0013195491718398 0.49638064335156 no 1661 0.499473576197053 2412 2859561
SGTC_2315 7733312 200 µM -0.00169781762586831 0.496507421094883 no 1662 0.499322669090041 2411 726316
SGTC_1002 4049-0206 172 µM -0.00189456990746982 0.496573363319364 no 1663 0.499244176412892 2411 4662749
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.00213985538600765 0.496655571747713 no 1664 0.499146321864073 2414 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2100 5377183 190 µM -0.00288417992004982 0.496905036005363 no 1665 0.498849380280845 2416 2844202
SGTC_2768 sulfasalazine 50.2 µM -0.00308980090014732 0.496973951168974 no 1666 0.498767349744234 2411 5384001 An antioxidant and salicylic acid derivative.
SGTC_985 1493-0307 8.71 µM -0.00419371129471914 0.497343935167328 no 1667 0.498326956156771 2414 3278274
SGTC_2348 9022543 33.42 µM -0.00484979142652901 0.497563826536165 no 1668 0.498065220733321 2422 3162678 YDL140C RPO21
SGTC_3189 9110682 49.47 µM -0.00596194571517471 0.497936577063266 no 1669 0.497621541871069 2412 17122418
SGTC_744 1594-0068 283 µM -0.00689138390597869 0.498248089711322 no 1670 0.497250757350237 2423 668392
SGTC_479 n-linoleoylglycine 10 µM -0.00699348661072305 0.498282310757928 no 1671 0.497210025245992 2418 6433346 An anti-infammatory.
SGTC_1503 4585-0012 61.3 µM -0.00722486240913397 0.498359859405991 no 1672 0.497117721990099 2426 2922052
SGTC_425 3825-7017 13.1 µM -0.00761646086467179 0.498491108928779 no 1673 0.496961501111549 2457 3397440
SGTC_2239 6685329 187.64 µM -0.00821137203290427 0.498690501766948 no 1674 0.496724173329002 2480 805680
SGTC_1966 st070145 16.1 µM -0.00893425143244752 0.498932785391576 no 1675 0.49643579677621 2421 3748532
SGTC_2376 9072922 81.32 µM -0.0103419084252647 0.499404583310655 no 1676 0.495874249014251 2477 17087968
SGTC_1842 st055362 61.2 µM -0.0109452158490778 0.499606791378102 no 1677 0.495633577811116 2437 676032
SGTC_3128 9127691 49.47 µM -0.011522934370019 0.499800423013608 no 1678 0.495403116013257 2456 41316314
SGTC_1794 st048918 76.9 µM -0.0127138481682468 0.499800423013608 no 1679 0.494928045059552 2422 672303
SGTC_1255 0566-0045 221 µM -0.0129568883347892 0.499718964192286 no 1680 0.494831094048029 2451 2788469
SGTC_796 1234-0020 70.7 µM -0.0130437007132505 0.499689867629859 no 1681 0.494796463846317 2432 46495034
SGTC_1334 1486-0610 236 µM -0.0132917051794376 0.499606744960881 no 1682 0.494697532956387 2490 3742339
SGTC_2767 sibutramine 71.45 µM -0.013383357121514 0.49957602634869 no 1683 0.494660972373645 2434 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3170 9103054 49.47 µM -0.0139325891848119 0.499391942509724 no 1684 0.494441880920235 2436 16432970
SGTC_522 1273-0010 11.6 µM -0.0142053952395711 0.499300507278388 no 1685 0.494333057821546 2538 5705015
SGTC_2235 salicylic acid 500 µM -0.0143453939411948 0.499253584530022 no 1686 0.494277212110915 2427 338 A COX inhibitor and kinase inhibitor.
SGTC_1213 1315-0166 115 µM -0.0152726323934334 0.498942806392293 no 1687 0.493907338061736 2470 768401
SGTC_3025 9087895 49.47 µM -0.0160643586785595 0.498677447728824 no 1688 0.493591523749204 2438 17173641
SGTC_1935 st074532 41.6 µM -0.0165957070472654 0.498499358859564 no 1689 0.493379574683908 2525 2829742
SGTC_1626 st003712 1.76 µM -0.0173169239339469 0.498257633374736 no 1690 0.493091892140436 2446 24207035
SGTC_2321 7390090 138.78 µM -0.0185937798028368 0.497829679678798 no 1691 0.492582582488924 2455 649046
SGTC_3181 9108277 49.47 µM -0.0195853868615558 0.497497332271045 no 1692 0.492187060596924 2434 17097298
SGTC_757 1066-0008 322 µM -0.0198510380476278 0.497408296801553 no 1693 0.492081101708101 2542 6842497
SGTC_1505 k297-0037 20.6 µM -0.0214280946906572 0.496879734385959 no 1694 0.491452081192809 2450 4089396
SGTC_831 k061-1017 217 µM -0.0226869105747933 0.49645783664456 no 1695 0.490950008498958 2469 1240153
SGTC_813 k007-0158 173 µM -0.0227841498594565 0.496425246624687 no 1696 0.490911225661809 2475 6523916
SGTC_203 k066-0004 30.888 µM -0.0235315023144842 0.496174770158914 no 1697 0.490613155112157 2431 6795412
SGTC_692 k241-0027 77.8 µM -0.0238183055391169 0.496078647957955 no 1698 0.490498769241282 2461 3600480
SGTC_3309 9129340 25.759 µM -0.0243654410109912 0.495895275949465 no 1699 0.490280557107519 2475 17158987
SGTC_1283 0922-0125 16.4 µM -0.0259315444007217 0.495370402598943 no 1700 0.489655969853986 2465 3360884
SGTC_1070 indatraline 8.81 µM -0.0263682358267286 0.495224048586444 no 1701 0.48948181473732 2476 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2345 9052315 157.45 µM -0.0285094373709426 0.494506449855807 no 1702 0.488627920578123 2481 6469265
SGTC_2197 6588183 93.1375 µM -0.0285709503163249 0.494485834760986 no 1703 0.488603390455872 2455 884136
SGTC_1349 flufenamic acid 69 µM -0.0300949398523219 0.49397509851187 no 1704 0.487995668158822 2461 3371 A non-steroidal anti-inflammatory.
SGTC_1766 st045414 44.774 µM -0.0331444207556683 0.492953153194158 no 1705 0.486779709776214 2467 253960
SGTC_2115 tiliquinol 12.7705 µM -0.0338078811776549 0.492730819518511 no 1706 0.486515175634343 2519 71208 A bioactive hydroxyquinoline.
SGTC_1553 gossypol 38.6 µM -0.0345983811324992 0.492465916300653 no 1707 0.48619999619882 2467 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0360895731494087 0.491966214388648 no 1708 0.485605468167355 2502 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_957 1187-1561 14.1 µM -0.0367283885627057 0.491752149669996 no 1709 0.485350786554642 2459 1538454
SGTC_760 0568-0725 82.9 µM -0.0376075275188917 0.491457557303808 no 1710 0.48500030303855 2475 3916171
SGTC_1216 1165-0504 9.65 µM -0.0384058193161505 0.491190060199944 no 1711 0.484682060631724 2480 6304004
SGTC_694 1315-0438 43.2 µM -0.0391338152049644 0.490946121783427 no 1712 0.484391850487351 2508 6793154
SGTC_2373 9071805 200 µM -0.0395400508971115 0.490810000926656 no 1713 0.484229911235477 2477 10149009
SGTC_2036 5160441 105 µM -0.0412280865127663 0.490244388083579 no 1714 0.483557031451903 2495 134534 YIL048W NEO1
SGTC_1258 0671-0043 57.1 µM -0.0414093942459251 0.490183638152671 no 1715 0.483484761848536 2502 4298767
SGTC_1956 st077085 54 µM -0.0416367373188453 0.490107463698559 no 1716 0.483394143239187 2512 24208685
SGTC_2256 7954252 200 µM -0.0418891006360654 0.490022906286773 no 1717 0.4832935526026 2543 2972920
SGTC_1178 0988-0033 191 µM -0.0423684487703538 0.489862296077523 no 1718 0.483102489994057 2544 5392207
SGTC_2907 7721985 69.9 µM -0.0425754725908644 0.489792931259253 no 1719 0.483019973896775 2523 3267881
SGTC_794 k038-0031 316 µM -0.0429444879815306 0.489669290768598 no 1720 0.482872892580545 2465 6624242
SGTC_1266 0828-0227 32.9 µM -0.0445779908002866 0.489121989395614 no 1721 0.482221843006821 2523 3913820
SGTC_2360 9040895 200 µM -0.044822762847861 0.489039980821858 no 1722 0.482124290597817 2505 4914414
SGTC_912 3474-0017 2.18 µM -0.0454281707564205 0.488837146590418 no 1723 0.481883013572124 2536 3360550
SGTC_2869 9037858 32.47 µM -0.0455815279897605 0.488785766653155 no 1724 0.481821896198175 2479 27187042
SGTC_1882 5615643 20 µM -0.0458198330045759 0.488705926662811 no 1725 0.481726925479811 2475 2253075
SGTC_2448 5185112 27.17 µM -0.0461668954144007 0.48858965019106 no 1726 0.481588613980031 2543 5718189
SGTC_1761 st044296 37 µM -0.0461750178852298 0.488586928927663 no 1727 0.481585377035026 2484 1826700
SGTC_67 0335-0847 266 µM -0.0462323212431602 0.488567730655232 no 1728 0.48156254069103 2654 4552207 YOR254C SEC63
SGTC_2141 5621638 7.665 µM -0.0474701463927784 0.488153030182329 no 1729 0.481069261614944 2560 2856238
SGTC_2194 5927483 104.545 µM -0.0484035187547568 0.48784033698392 no 1730 0.480697327516579 2481 760979
SGTC_1392 3455-1037 33.9 µM -0.0486114578667575 0.48777067539472 no 1731 0.480614469352221 2562 981132
SGTC_620 0109-0052 432 µM -0.0489578494083358 0.487654631748326 no 1732 0.480476443465996 2506 493037
SGTC_2411 st077133 39.94 µM -0.0499460972201334 0.487323567434088 no 1733 0.48008267142515 2743 1403142 YNL221C POP1
SGTC_1499 4480-0877 67.3 µM -0.0501688326946097 0.487248951955903 no 1734 0.479993924086215 2491 2861909
SGTC_604 1000-0114 314 µM -0.051295291296191 0.486871599796118 no 1735 0.479545110084156 2504 1572745
SGTC_942 3253-1115 227 µM -0.0520178373256521 0.486629560401036 no 1736 0.479257240262061 2546 46497897
SGTC_2851 9015922 71.43 µM -0.0529152131792476 0.48632896315418 no 1737 0.478899731507074 2544 2996893
SGTC_2302 7771753 200 µM -0.0541453135260647 0.485916924631797 no 1738 0.478409695100636 2545 2203047
SGTC_1189 1431-2119 7.28 µM -0.05422511456126 0.48589019472499 no 1739 0.478377905795251 2497 3107275
SGTC_600 1495-0418 41.6 µM -0.0544856653860913 0.485802921872268 no 1740 0.478274114494768 2516 5377768
SGTC_3173 9105693 49.47 µM -0.0555492381092947 0.48544667975943 no 1741 0.47785045206873 2561 17096658
SGTC_1667 st014849 34.6 µM -0.0577198847223603 0.484719661229139 no 1742 0.476985877191379 2496 5348460
SGTC_2165 5727197 32.143 µM -0.0582273696488037 0.484549695636947 no 1743 0.476783759937396 2815 1361712
SGTC_1175 0741-0056 27.6 µM -0.0587592183541886 0.484371573201444 no 1744 0.476571945672253 2558 765927
SGTC_2720 fluspirilene 36.88 µM -0.0589213549852746 0.48431727234052 no 1745 0.476507374390465 2568 3396 An atypical antipsychotic.
SGTC_2037 5169046 200 µM -0.0596201623297353 0.484083239485029 no 1746 0.476229079857648 2585 5718022
SGTC_1903 st060211 78.3 µM -0.0609420344862391 0.483640555256483 no 1747 0.475702686479743 2511 688960
SGTC_3081 9117243 49.47 µM -0.0611069837768707 0.483585316485314 no 1748 0.475637003648721 2626 45595589
SGTC_2800 7887935 81.82 µM -0.0611439067414515 0.483572951642329 no 1749 0.475622301009588 2578 2961002
SGTC_1508 1080-0625 72.9 µM -0.0616316854564753 0.483409604728838 no 1750 0.475428071776307 2486 767111
SGTC_2224 6650123 117.647 µM -0.0630597071266362 0.482931406179181 no 1751 0.474859479732112 2516 2908370
SGTC_1173 0443-0020 122 µM -0.0639369186733797 0.482637668362434 no 1752 0.474510227776832 2540 5331295
SGTC_2166 5933061 31.504 µM -0.0644721159998301 0.482458460002521 no 1753 0.474297154557736 2739 2877375
SGTC_3197 9113331 49.47 µM -0.0652815602714298 0.482187428061463 no 1754 0.473974911897384 2572 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2533 agelasine 13.65 µM -0.0653991427780087 0.482148057762322 no 1755 0.473928103292256 2563 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1470 k295-0292 231 µM -0.0660816525811482 0.481919535593371 no 1756 0.47365640901919 2625 5045612
SGTC_1088 bifonazole 369 nM -0.067247051603592 0.481529343231477 no 1757 0.473192514054022 2501 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2051 5263410 176 µM -0.0682047917103533 0.481208691291495 no 1758 0.472811306311543 2514 227584
SGTC_580 1123-0028 41 µM -0.0692797104780613 0.480848822357566 no 1759 0.472383487810302 2533 1677248 YPR107C YTH1
SGTC_2045 5106652 78.05 µM -0.0709120846513488 0.480302354489432 no 1760 0.471733862714385 2576 673349
SGTC_487 nimodipine 119 µM -0.0712975402341075 0.480173321368591 no 1761 0.471580476429102 2514 4497 L-type voltage-gated calcium channels inhibitor
SGTC_491 tetrandrine 80.3 µM -0.0718967159312869 0.47997274853528 no 1762 0.471342051797546 2598 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_228 caffeine 993.056 µM -0.0727249847125524 0.479695495622931 no 1763 0.471012483131935 2543 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3164 9100705 49.47 µM -0.0727690980942478 0.47968072947866 no 1764 0.470994930944594 2629 17174235
SGTC_3257 9139206 32.98 µM -0.0737924188495338 0.479338199519921 no 1765 0.470587779730761 2556 4910041
SGTC_1269 0831-0796 3.05 µM -0.0740817603975485 0.479241352732012 no 1766 0.470472664235148 2582 927758
SGTC_382 3229-0966 23.2 µM -0.074559433985077 0.479081471179488 no 1767 0.47028262561609 2603 5722370
SGTC_2480 5767542 37.17 µM -0.0746635824723493 0.479046612210503 no 1768 0.470241191870037 2585 2867358
SGTC_1446 4239-0190 62 µM -0.0758152833194998 0.478661143481478 no 1769 0.4697830283954 2555 1340085
SGTC_2091 4-phenylthiadiazole 200 µM -0.0763906068348846 0.478468592923564 no 1770 0.469554171215145 2573 270010
SGTC_3032 9089427 49.47 µM -0.0767150978069886 0.478359993774614 no 1771 0.469425096811872 2616 17173707
SGTC_1229 0139-0193 12.2 µM -0.0776051474817545 0.478062124306881 no 1772 0.469071073817374 2555 3090752
SGTC_1947 st076332 61.6 µM -0.0778447825762731 0.477981928647417 no 1773 0.468975761580501 2530 24208416
SGTC_2692 st077426 47.7 µM -0.0783979779392308 0.477796801131442 no 1774 0.468755740976475 2561 25238571
SGTC_2954 9074818 52.69 µM -0.0786135537560389 0.477724659711417 no 1775 0.468670003283547 2609 16648742
SGTC_1757 st041620 31.8375 µM -0.0787577863116474 0.477676393381252 no 1776 0.468612640672533 2599 5289815
SGTC_3308 9128332 17.569 µM -0.079977217479459 0.477268333152431 no 1777 0.468127687866937 2610 17332805 YDL196W YDL196W
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0801586863063382 0.477207609971542 no 1778 0.46805552396749 2645 688751
SGTC_281 1672-3440 14.9 µM -0.0807343446823412 0.477014986414298 no 1779 0.467826611425094 2601 6833000
SGTC_3343 9148379 18.9835 µM -0.0808816097284177 0.476965710276463 no 1780 0.46776805267654 2602 1955036
SGTC_17 0960-0276 49.807 µM -0.0810960682182475 0.476893951270564 no 1781 0.467682776249058 2547 6821114
SGTC_809 3998-0021 90 µM -0.0827488956164619 0.476340931324864 no 1782 0.46702560253908 2541 715485
SGTC_2446 5162541 200 µM -0.0828541920054551 0.476305701711567 no 1783 0.466983739113641 2543 1549321
SGTC_3112 9123419 49.47 µM -0.0832159371250016 0.476184671996951 no 1784 0.466839920349493 2546 17015854
SGTC_3313 9133968 57.047 µM -0.0833131182711963 0.476152158300194 no 1785 0.46680128484346 2542 1494643
SGTC_1247 0448-0043 5.84 µM -0.0837265576342908 0.47601383651774 no 1786 0.466636920669535 2627 3089013 YGL099W LSG1
SGTC_1329 1447-1697 50.6 µM -0.0844259840446587 0.475779840454567 no 1787 0.466358874376294 2673 2840515
SGTC_302 1094-0063 18.9 µM -0.0845181341267862 0.475749011875922 no 1788 0.466322242738874 2552 5440289
SGTC_2065 5221596 34.26 µM -0.0848304333950461 0.475644534020493 no 1789 0.466198099193903 2665 788581
SGTC_1032 k061-1018 98.7 µM -0.0863023125962551 0.475152148286142 no 1790 0.465613050075599 2764 4005393
SGTC_2524 avocatin b 10.57 µM -0.0871125081239262 0.474881130829962 no 1791 0.465291041569109 2620 6710748
SGTC_1003 4049-0218 100 µM -0.0874178613723792 0.474778990519422 no 1792 0.465169686202577 2650 295161
SGTC_2244 6635614 200 µM -0.088372895001093 0.474459543599076 no 1793 0.464790151823379 2560 836499
SGTC_2122 5258151 111.688 µM -0.088483272610452 0.474422624710451 no 1794 0.464746289355755 2604 2173356
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0894398566957447 0.474102677555705 no 1795 0.464366174658012 2745 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1802 st050112 57.9 µM -0.0894914321029858 0.474085427684138 no 1796 0.46434568122752 2533 4662563
SGTC_995 3931-2021 34.6 µM -0.0895365885496385 0.47407032473315 no 1797 0.464327738441514 2637 730143
SGTC_650 1328-0195 38 µM -0.0911368682321875 0.47353512204104 no 1798 0.463691918957263 2549 2780821
SGTC_1059 3448-6867 171 µM -0.091774085121904 0.473322022414889 no 1799 0.463438767113482 2535 3934407
SGTC_1196 1588-0294 184 µM -0.0932894734265291 0.472815273341281 no 1800 0.462836797301026 2641 6144269
SGTC_457 grayanotoxin iii 135 µM -0.0936944846030469 0.472679844158641 no 1801 0.46267592582703 2639 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1291 0993-0025 5.79 µM -0.0941215253778987 0.472537052055684 no 1802 0.462506310752425 2649 4353356
SGTC_1736 st036774 51 µM -0.0946975572446211 0.472344446531031 no 1803 0.46227752914808 2775 1272247
SGTC_1375 2910-0797 186 µM -0.0974449884224185 0.471425888454744 no 1804 0.461186509551848 2647 742508
SGTC_2934 9036370 36.88 µM -0.0982461278432042 0.471158069170974 no 1805 0.460868427442797 2660 6462800
SGTC_2824 7998404 51.95 µM -0.0984164840028758 0.471101121129819 no 1806 0.46080079294028 2580 837851
SGTC_1388 3346-4487 254 µM -0.0987506276695655 0.47098942258743 no 1807 0.460668135105322 2650 3345614
SGTC_2644 guaiazulene 100 µM -0.099850369644986 0.470621813720432 no 1808 0.460231559317728 2649 3515 A coloring agent.
SGTC_1907 st060210 83.7 µM -0.0999452279156479 0.470590106777026 no 1809 0.460193904700917 2630 688793
SGTC_2173 5763948 167 µM -0.099972635549891 0.470580945646327 no 1810 0.460183025126013 2587 2867177
SGTC_3067 9117431 49.47 µM -0.100242447778165 0.47049076047141 no 1811 0.460075923627393 2631 17150885
SGTC_3113 9123498 49.47 µM -0.100348634117407 0.470455267930076 no 1812 0.460033773937099 2568 8897275
SGTC_1117 retinoic acid 1.10837 µM -0.102086736746216 0.469874344663757 no 1813 0.459343914276604 2620 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_71 0417-1750 47.813 µM -0.102310024293155 0.469799720244918 no 1814 0.459255299413449 2602 6811472
SGTC_2915 7971052 15.16 µM -0.102852177181069 0.469618532991639 no 1815 0.459040146703195 2580 5741558
SGTC_3001 9076041 71.4286 µM -0.103580394301911 0.4693751730613 no 1816 0.458751173520386 2607 16004211
SGTC_2813 7971799 71.43 µM -0.105122026687593 0.468860019034793 no 1817 0.458139490684601 2679 2234054
SGTC_285 1486-1325 46 µM -0.106838888722644 0.46828637141869 no 1818 0.457458397642858 2682 22310230
SGTC_3052 9092717 49.47 µM -0.107105194090863 0.468197397837209 no 1819 0.457352763292463 2728 25237534
SGTC_2639 lactacystin 53 µM -0.107719430576169 0.467992185282813 no 1820 0.457109127913762 2671 3870 A proteasome inhibitor.
SGTC_469 w7 172 µM -0.109717609615717 0.467324665329094 no 1821 0.456316667139229 2589 45115570 A P450 inhibitor.
SGTC_332 4112-0506 40.9 µM -0.110084687782166 0.467202047613148 no 1822 0.456171105862627 2607 2790355
SGTC_739 1486-1183 203 µM -0.110812964585744 0.46695878538597 no 1823 0.455882332209525 2598 4346692
SGTC_874 0599-0792 117 µM -0.111167666800048 0.46684031065275 no 1824 0.455741695415082 2603 765305
SGTC_803 4488-1585 147 µM -0.11183179867577 0.466618490662557 no 1825 0.455478386982839 2687 747204
SGTC_246 cycloheximide 667 µM -0.11199953926323 0.466562466957904 no 1826 0.455411885943884 2592 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1996 st072960 66.8 µM -0.112238985573141 0.466482495396087 no 1827 0.455316959215304 2587 1719405
SGTC_1125 tnp00248 1.32998 µM -0.112545063946348 0.466380271671558 no 1828 0.455195620410793 2745 24207736
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.112722063807809 0.466321158460651 no 1829 0.455125454172768 2582 1241132 A phosphatase inhibitor.
SGTC_135 0933-0004 26.348 µM -0.113153261470067 0.466177153107935 no 1830 0.45495452477385 2693 21230617 YGL099W LSG1
SGTC_616 4092-0450 108 µM -0.113655334585953 0.466009483345425 no 1831 0.454755510420943 2660 787165
SGTC_2711 st079103 59.1 µM -0.114592771056317 0.465696438041505 no 1832 0.454383954911953 2706 54693780
SGTC_1347 1493-0251 600 nM -0.115498001971789 0.46539416752569 no 1833 0.454025202037664 2696 3986378
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.116205804275278 0.465157835357619 no 1834 0.453744718387014 2616 688664
SGTC_2022 5136654 200 µM -0.117742980898788 0.464644621081285 no 1835 0.453135654896 2745 1713771
SGTC_1016 4226-1401 38 µM -0.117833841994834 0.46461428729011 no 1836 0.453099657149661 2584 2901613
SGTC_949 1165-0505 146 µM -0.117839213680671 0.464612493970211 no 1837 0.453097528983741 2621 6244267
SGTC_411 enrofloxacin 100 µM -0.118018102917595 0.464552772789315 no 1838 0.453026657035171 2733 71188 A bacterial gyrase inhibitor.
SGTC_438 sphingosine 6.67 µM -0.118088369725956 0.464529314822908 no 1839 0.452998819293116 2617 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1097 itavastatin 7.23 µM -0.118162967321776 0.464504411195478 no 1840 0.452969266067114 2627 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2156 5649887 115 µM -0.119538355044143 0.464045277401724 no 1841 0.452424427469567 2732 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_359 0081-0058 15.9 µM -0.120698592055695 0.463658002713966 no 1842 0.451964887110182 2917 3494159
SGTC_2911 7942208 15.64 µM -0.121835167348454 0.463278659440659 no 1843 0.451514780945488 2704 1243384
SGTC_1600 coumarin 106 71.1 µM -0.121929627856512 0.463247133807509 no 1844 0.45147737552413 2778 100336 A hepatotoxic, DNA x-linker.
SGTC_165 k038-0023 64.381 µM -0.122302590052466 0.463122662147928 no 1845 0.451329690417049 2650 46368543
SGTC_1581 himbacine 57.9 µM -0.124352706890662 0.462438525033225 no 1846 0.45051800852516 2617 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_699 0375-0592 111 µM -0.12435325970725 0.462438340569683 no 1847 0.450517789681868 2633 762578
SGTC_1241 0364-0022 50.8 µM -0.124371082166454 0.4624323935854 no 1848 0.450510734319784 2711 4563895
SGTC_854 0422-0053 192 µM -0.125521153031404 0.46204865665064 no 1849 0.45005548988794 2635 3596728
SGTC_1010 4112-3296 15.2 µM -0.128581171422958 0.461027812484145 no 1850 0.44884453282232 2736 704384
SGTC_1407 3909-7909 12.3 µM -0.129551391728916 0.460704193296423 no 1851 0.448460681406031 2647 4411780
SGTC_1829 berberine 14.4 µM -0.129728453399758 0.460645136775538 no 1852 0.448390635116293 2802 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_987 1497-1013 404 µM -0.130790915149802 0.460290785333414 no 1853 0.44797035495984 2635 1676435
SGTC_787 4152-0075 138 µM -0.130966530852362 0.460232217146081 no 1854 0.447900891910641 2677 9566539
SGTC_2370 9071495 200 µM -0.130988738692642 0.460224810848448 no 1855 0.447892107933445 2695 21791103
SGTC_1210 3013-0140 750 nM -0.131640819726147 0.460007348488193 no 1856 0.447634198496815 2788 905973
SGTC_1818 st052136 56.3 µM -0.132532000533582 0.459710168155955 no 1857 0.447281756747753 2675 674169
SGTC_3291 9121177 71.43 µM -0.132916966337672 0.459581801309176 no 1858 0.447129524381897 2672 17015612
SGTC_2691 st077356 60.2 µM -0.133927062678483 0.459245004751517 no 1859 0.446730125069141 2783 2839272
SGTC_753 1322-0200 289 µM -0.134511573359719 0.459050124620906 no 1860 0.446499030019768 2782 5403907
SGTC_3288 9119690 36.221 µM -0.134708348017601 0.458984520724302 no 1861 0.446421236296522 2678 17595618 YKL019W RAM2
SGTC_2432 5630864 12.22 µM -0.13559851483068 0.458687756593724 no 1862 0.446069339801207 2765 5714970
SGTC_167 3672-0051 66.205 µM -0.136916203771004 0.458248507296004 no 1863 0.445548515349455 2635 3237971
SGTC_727 3032-0951 202 µM -0.137118975352171 0.458180918257833 no 1864 0.445468376985932 2723 3652836
SGTC_1855 st056195 39.6 µM -0.137465721127874 0.458065341681519 no 1865 0.445331343030633 2784 4028379
SGTC_2297 7971671 152.32 µM -0.140358355371362 0.457101313977102 no 1866 0.444188429835009 2775 909016
SGTC_2958 9077254 16.72 µM -0.141552667631479 0.456703359031666 no 1867 0.443716678051635 2821 16457351
SGTC_1988 st071872 53.4 µM -0.142728589559805 0.456311574319384 no 1868 0.443252268336216 2645 16414116
SGTC_1454 4239-0054 42.6 µM -0.143180498285326 0.456161022088047 no 1869 0.443073815617963 2836 1340767
SGTC_860 0443-0016 25.1 µM -0.145022898022988 0.455547296708927 no 1870 0.442346396449152 2687 5337942
SGTC_1502 4534-4282 27.7 µM -0.145893476482898 0.455257333426242 no 1871 0.442002740750237 2684 3278949
SGTC_423 5-fluorouracil 457 µM -0.148801616036013 0.454288893994682 no 1872 0.440855087712517 2648 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_561 1550-0330 72.9 µM -0.148891846725684 0.454258850592315 no 1873 0.440819487436141 2691 6812934
SGTC_2700 st077718 96.8 µM -0.149434054981445 0.45407832129535 no 1874 0.440605570706553 2740 904970
SGTC_2850 9015429 58.44 µM -0.150433603639722 0.453745544510557 no 1875 0.440211265523837 2730 6457570
SGTC_843 0310-0051 143 µM -0.151268113274248 0.453467738543197 no 1876 0.439882110862356 2684 2065037
SGTC_2203 7227154 166.4 µM -0.151490480830918 0.453393716830077 no 1877 0.439794409687775 2674 896304
SGTC_2434 5670830 169.91 µM -0.151907973653659 0.453254746193492 no 1878 0.439629759609368 2766 1549830
SGTC_2684 capsaicin 100 µM -0.152217478632501 0.453151725112981 no 1879 0.439507704323458 2759 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3270 9137563 49.47 µM -0.152279451745043 0.453131097270916 no 1880 0.43948326551715 2791 17015724
SGTC_1483 3453-0561 55.9 µM -0.153432261670233 0.452747405900231 no 1881 0.439028702475029 2771 4546991
SGTC_392 N-ethylmaleimide 8.33 µM -0.154432347455723 0.45241458164668 no 1882 0.438634425001208 2718 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2749 bexarotene 57.39 µM -0.155518091861712 0.452053288430895 no 1883 0.438206446108315 2784 82146 An retinoic acid receptor inhibitor.
SGTC_3054 9094397 49.47 µM -0.156748131537356 0.451644027383609 no 1884 0.437721676213112 2723 2598354
SGTC_2195 6536160 144.242 µM -0.159207610770562 0.450825859488702 no 1885 0.436752653908451 2678 3834386
SGTC_64 000l-0018 272.079 µM -0.161597152680385 0.450031156903878 no 1886 0.435811549837119 2682 6811119
SGTC_788 1182-0090 188 µM -0.163325580287189 0.449456449275294 no 1887 0.435131047079656 2913 5715185
SGTC_1262 0737-0114 49.6 µM -0.16475450259754 0.448981408094206 no 1888 0.434568608111904 2742 765919
SGTC_1149 3909-7961 23.3 µM -0.165822113093101 0.448626531694404 no 1889 0.434148471654658 2707 735261
SGTC_771 0250-0039 27.3 µM -0.166005972282831 0.448565420580497 no 1890 0.434076125093444 2681 3005115
SGTC_3277 9138724 49.47 µM -0.166463618254511 0.44841331352391 no 1891 0.433896056049946 2772 15943418
SGTC_288 1315-0019 35.1 µM -0.166682578363313 0.448340540784946 no 1892 0.433809907103986 2755 6811474
SGTC_387 norethindrone acetate 66.7 µM -0.167060085612017 0.448215078012355 no 1893 0.433661385829477 2754 541197
SGTC_2090 5301565 104.445 µM -0.167585684933115 0.448040406159297 no 1894 0.433454616844151 2729 2056344
SGTC_219 mitoxanthrone 164.414 µM -0.168978523079746 0.447577574576422 no 1895 0.432906767279877 2773 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2467 5474540 200 µM -0.172188945416671 0.446511043765168 no 1896 0.431644494181106 2695 5413519
SGTC_1678 st019265 80.2 µM -0.172372326033858 0.446450134700912 no 1897 0.431572413574792 2904 5367020
SGTC_2797 7859098 81.82 µM -0.175257041103652 0.445492156468877 no 1898 0.430438832753466 2752 972681
SGTC_1379 2144-0755 36.5 µM -0.175260125918664 0.445491132209238 no 1899 0.430437620846198 2820 5392327
SGTC_2731 amoxapine 43.43 µM -0.175976620865795 0.445253242285585 no 1900 0.430156154824846 2712 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1251 0490-5699 265 µM -0.177189832982939 0.444850477824982 no 1901 0.429679640706043 2810 3883818
SGTC_395 anisomycin 6.25 µM -0.177232693707889 0.444836249878894 no 1902 0.429662808140167 2777 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3293 9120939 62.045 µM -0.177478125380852 0.444754778323541 no 1903 0.429566422947734 2866 934087
SGTC_2732 terfenadine 20 µM -0.178950876102687 0.444265944790294 no 1904 0.428988137069348 2713 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_360 0957-0399 1.01 µM -0.179323570042567 0.444142254106134 no 1905 0.428841820298438 2868 6752301 YPR165W RHO1
SGTC_2979 9012552 45.46 µM -0.179862074725123 0.443963543311711 no 1906 0.428630424783696 2817 17100905
SGTC_115 0527-0192 112.043 µM -0.184964104128351 0.442270929297016 no 1907 0.426628595241604 2813 4233931
SGTC_2072 5231554 129 µM -0.186240943695081 0.441847497410569 no 1908 0.42612790858577 2837 789545
SGTC_2722 naftopidil 47.16 µM -0.187056895552275 0.441576942164126 no 1909 0.425808011964486 2742 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_156 3474-0145 5.642 µM -0.187537217424942 0.441417688639126 no 1910 0.425619723003175 2668 2265471
SGTC_3016 9080866 49.47 µM -0.187631553721212 0.44138641200048 no 1911 0.425582744618895 2759 17066299
SGTC_1686 st019653 115.5 µM -0.189326448163491 0.440824542278405 no 1912 0.4249184837638 2829 97252
SGTC_751 0833-0568 350 µM -0.189850807095646 0.440650737584868 no 1913 0.424713020764277 2818 6954252
SGTC_2414 st077232 92.9 µM -0.190603103078264 0.440401400555738 no 1914 0.424418279430434 2718 729801
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.190608278888086 0.440399685194249 no 1915 0.424416251750973 2894 23847180
SGTC_2279 7948423 32.93 µM -0.190665416764207 0.440380748693326 no 1916 0.424393867503153 2864 1247112
SGTC_340 k038-0059 454 µM -0.190767037930977 0.440347069981466 no 1917 0.424354057151331 2740 23733424
SGTC_185 k048-0037 25.491 µM -0.191948781812028 0.439955454865384 no 1918 0.423891162738661 2817 6827589
SGTC_784 4579-0127 173 µM -0.192335338103358 0.439827367684324 no 1919 0.42373976965212 2948 1948547
SGTC_1395 3486-0190 4.35 µM -0.193533335753298 0.439430445790681 no 1920 0.423270650685215 2846 6748079
SGTC_2198 6589944 200 µM -0.194341549814011 0.439162701791097 no 1921 0.422954226862907 2782 5290268
SGTC_2391 6285546 200 µM -0.194664819608833 0.439055617220637 no 1922 0.422827677434425 2725 846083
SGTC_1438 4092-1045 4 µM -0.194741355902167 0.439030264882667 no 1923 0.422797717173391 2746 1351342
SGTC_1983 st071813 46.9 µM -0.195208585736254 0.438875502315411 no 1924 0.422614828957312 2811 11838595
SGTC_223 busulfan 5 mM -0.196825480762074 0.438340003421956 no 1925 0.421982055189298 2858 2478 A DNA alkylator.
SGTC_234 nsc-17383 10.7 µM -0.197708487002893 0.438047608485756 no 1926 0.421636574561208 2886 408974
SGTC_2719 novobiocin 32.65 µM -0.200235081358424 0.437211150129301 no 1927 0.420648365875037 2861 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2367 9070478 135.38 µM -0.200434658735524 0.437145089632836 no 1928 0.420570327831035 2750 572802
SGTC_1429 4049-0205 9.46 µM -0.201448521115381 0.436809526332368 no 1929 0.420173939200878 2755 22774478
SGTC_608 k048-0125 159 µM -0.201849861838507 0.436676705054388 no 1930 0.420017049814405 2865 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2508 celastrol 40.54 µM -0.202465126024312 0.436473100969161 no 1931 0.419776559606903 2746 122724 Celastrol is a natural product and antioxidant.
SGTC_2992 9074591 71.4286 µM -0.202875067065656 0.436337452045226 no 1932 0.41961634131275 2824 17741321
SGTC_2953 9074162 66.49 µM -0.203781407763998 0.436037571758401 no 1933 0.419262161216581 2875 16451992
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.205051772035892 0.435617309177301 no 1934 0.418765838031263 2745 803109
SGTC_1293 1000-1278 195 µM -0.205246915698824 0.43555275807707 no 1935 0.418689608086688 2905 678847
SGTC_724 3910-0327 137 µM -0.20648769281031 0.435142364656609 no 1936 0.418204988659355 2819 2885483
SGTC_837 0091-0265 12.5 µM -0.20790948807819 0.434672184457252 no 1937 0.417649820319132 2781 759367
SGTC_1564 D-Arginine 115 µM -0.208107612420236 0.434606673099944 no 1938 0.417572471716568 2802 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1343 1487-0095 224 µM -0.208474715879924 0.434485292227733 no 1939 0.417429161364647 2807 4560101 YGL055W OLE1
SGTC_1299 1079-1439 3.74 µM -0.208976749543718 0.434319307376636 no 1940 0.417233194533161 2803 323161
SGTC_484 loperamide 105 µM -0.210172464406 0.433924020900475 no 1941 0.416766534903036 2741 3955 An opioid-receptor agonist.
SGTC_144 4161-2749 112.381 µM -0.213422350757766 0.432849989222514 no 1942 0.415498774346586 2780 797501 YMR168C CEP3
SGTC_1716 st033144 30.6155 µM -0.214171669655184 0.432602422242208 no 1943 0.415206593917044 2928 674617
SGTC_1462 k081-0014 26.5 µM -0.215012501469061 0.432324651872161 no 1944 0.414878785870351 2808 3270634
SGTC_592 k241-0073 46.5 µM -0.216406480883484 0.431864221904062 no 1945 0.414335457472575 2902 4230158
SGTC_1682 st012968 530 nM -0.218269153029155 0.431249127754651 no 1946 0.413609703672535 2802 24207270
SGTC_2487 5918373 44.05 µM -0.218348667553859 0.431222874058624 no 1947 0.413578728940327 2791 2876279
SGTC_1889 st059080 5.18 µM -0.219015988471947 0.431002553463976 no 1948 0.41331879655634 2884 176925 Isolated from Daphnopsis sellowiana.
SGTC_2331 7980721 200 µM -0.219379482762414 0.430882552349959 no 1949 0.413177225574798 2868 2981221
SGTC_3354 9151612 71.43 µM -0.221005763149498 0.430345743369575 no 1950 0.412543972793256 2939 27261949
SGTC_2288 7946289 167.31 µM -0.221999163659168 0.430017901106417 no 1951 0.412157267196056 2981 1246052
SGTC_2005 4024620 188 µM -0.224215514640219 0.429286634661134 no 1952 0.411294805920326 2791 236743
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.224597007451514 0.429160788706537 no 1953 0.411146396563027 2783 16486 A toxic proline analog.
SGTC_1880 MG-132 525 µM -0.225091070603808 0.428997819013687 no 1954 0.410954213689719 2911 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3335 9143315 29.6265 µM -0.226735565008991 0.428455460014593 no 1955 0.410314685174579 2851 4899691
SGTC_2333 9017922 200 µM -0.22720833237676 0.428299564929758 no 1956 0.410130874410953 2949 3163164
SGTC_1332 1480-0653 17.5 µM -0.227495368580626 0.428204920171307 no 1957 0.410019285086622 2897 5749438
SGTC_3191 9110352 49.47 µM -0.2275526955405 0.428186018185316 no 1958 0.409996999304746 2774 17122424
SGTC_656 4090-1979 187 µM -0.228939165893022 0.427728918057694 no 1959 0.409458099441976 2927 22330961
SGTC_1609 st001574 46.4 µM -0.228989098246855 0.427712457855812 no 1960 0.409438694682964 2808 3960012
SGTC_3002 9075603 71.4286 µM -0.229038391767715 0.427696208368645 no 1961 0.409419538405464 2818 20105405
SGTC_889 0919-1524 82.7 µM -0.232234094153868 0.426643015904893 no 1962 0.408178099110227 2877 3905452
SGTC_3314 9135860 59.4275 µM -0.235800727521201 0.425468195132568 no 1963 0.406793651797253 2938 25252478
SGTC_2287 7945887 168.79 µM -0.23810256510762 0.424710338580538 no 1964 0.405900772638996 2926 1245853
SGTC_2955 9076254 12.21 µM -0.238576582573258 0.424554307617996 no 1965 0.405716962614239 2940 16459619
SGTC_743 1275-0778 158 µM -0.239149131042422 0.424365859254232 no 1966 0.405494972885053 2938 2849257 YMR203W TOM40
SGTC_131 0141-0277 33.849 µM -0.239692283838085 0.42418710214979 no 1967 0.405284408601906 3005 1547771
SGTC_3339 9145883 14.936 µM -0.24087824881446 0.423796843275241 no 1968 0.40482474038796 2980 2030670
SGTC_3256 9138902 49.47 µM -0.241629662667573 0.423549618360307 no 1969 0.404533567770506 2815 17228773
SGTC_482 fipronil 114 µM -0.241882635814386 0.423466393676122 no 1970 0.404435552646785 2816 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_330 1488-0319 80.1 µM -0.242578534004436 0.423237470373285 no 1971 0.404165955986677 2893 6846614
SGTC_504 lovastatin 124 µM -0.242656587646977 0.423211795390698 no 1972 0.40413572020214 2857 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_767 0929-0023 86 µM -0.243268675492717 0.423010466391824 no 1973 0.403898634463308 2851 1204563
SGTC_1619 st003326 88.7 µM -0.243338317234524 0.422987560981864 no 1974 0.403871661707913 3003 2849032
SGTC_2080 5212524 12.4 µM -0.244042453708799 0.422755982693763 no 1975 0.403598970202822 2870 260183
SGTC_1507 4075-3230 155 µM -0.244912160000966 0.422469988213207 no 1976 0.403262223029985 2791 659771
SGTC_2543 pimpinellin 60.67 µM -0.245262453594057 0.42235480909852 no 1977 0.403126610848115 2861 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_979 1426-2828 121 µM -0.246611165290777 0.421911404831449 no 1978 0.402604581371165 2981 747872
SGTC_2895 9054447 58.44 µM -0.247047062292157 0.421768119884109 no 1979 0.40243590108359 2856 2697450
SGTC_1509 1326-1131 80 µM -0.249827217525851 0.420854491569996 no 1980 0.401360485233599 2920 768313
SGTC_2805 7950783 58.44 µM -0.250976911748029 0.420476797645081 no 1981 0.400915979874907 2976 1178958 YDL195W SEC31
SGTC_1632 st005650 90 µM -0.251582643111147 0.420277834107433 no 1982 0.400681837988961 2973 2759605
SGTC_1331 1472-0049 76.2 µM -0.25218691259142 0.420079371047321 no 1983 0.400448296734598 2840 24051409
SGTC_557 1315-0110 16.2 µM -0.253193906501782 0.419748684484271 no 1984 0.400059187524062 2846 6833801
SGTC_38 0929-0051 58.268 µM -0.255520241471993 0.418984956742238 no 1985 0.3991606559654 2989 1379719
SGTC_923 1900-2434 73.3 µM -0.256570172023667 0.418640367945476 no 1986 0.39875530180722 2825 5910570
SGTC_969 1313-0238 134 µM -0.257929955535682 0.418194177743874 no 1987 0.398230482838883 2868 5212874
SGTC_1998 st075797 76.8 µM -0.25827303808143 0.418081617554908 no 1988 0.398098096514599 2940 24208315
SGTC_1555 citronellol 128 µM -0.258619228122204 0.417968044644651 no 1989 0.397964522981578 2940 8842 A terpine precursor.
SGTC_2791 5663188 71.43 µM -0.25938450357286 0.417717008676796 no 1990 0.397669292514397 3028 54690634
SGTC_1413 3910-0535 34.4 µM -0.260585255233695 0.417323189542972 no 1991 0.397206180773624 2980 2876951
SGTC_2680 butyl paraben 22.24 µM -0.261034538116242 0.417175856311381 no 1992 0.397032936380408 2855 7184 An antifungal and steroid mimetic.
SGTC_3013 9080133 71.4286 µM -0.261945429058009 0.416877183767059 no 1993 0.396681757365912 3069 17050193
SGTC_2014 4013930 200 µM -0.26289395958207 0.416566220545198 no 1994 0.396316156080977 2905 64556
SGTC_3216 9129716 49.47 µM -0.263353062645001 0.416415728398536 no 1995 0.396139232270538 2907 8056934
SGTC_1115 galangin 695.678 nM -0.263830173959687 0.416259346200991 no 1996 0.395955391314378 2993 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1389 3405-0187 19 µM -0.264536418864038 0.416027885504324 no 1997 0.395683302888727 2922 799890
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.264539326477489 0.416026932639735 no 1998 0.395682182804429 2864 688803
SGTC_2284 7945075 39.21 µM -0.26543893857428 0.415732141214381 no 1999 0.395335671486347 3023 1245402
SGTC_2351 9026858 72.31 µM -0.265517188132237 0.415706502070053 no 2000 0.395305535339422 2851 1409300
SGTC_2630 antimycin a 100 µM -0.265672563527804 0.415655593041827 no 2001 0.395245697678589 2814 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2154 5570129 200 µM -0.265710985934826 0.415643004089241 no 2002 0.395230900948554 2879 673366
SGTC_2102 5377816 72.7585 µM -0.266351569871116 0.415433132011934 no 2003 0.394984229991382 3064 1379702
SGTC_530 4358-1714 28 µM -0.266756526823967 0.41530046994818 no 2004 0.394828314100272 2974 1564641
SGTC_1167 k781-0610 148 µM -0.267778000594487 0.414965882693824 no 2005 0.394435102744673 2936 4525169
SGTC_2656 pseudo-anisatin 100 µM -0.26806016637928 0.414873469178619 no 2006 0.394326503339136 2891 6708809 A neurotoxin.
SGTC_518 1021-0119 62.6 µM -0.269593963143873 0.414371210319487 no 2007 0.393736322577043 2920 1097762
SGTC_3242 9133940 49.47 µM -0.269898105237481 0.414271632203975 no 2008 0.39361932245158 3034 17248444
SGTC_3337 9144342 33.5465 µM -0.271325048082502 0.41380451543588 no 2009 0.393070521593708 2966 17682949
SGTC_966 1300-0360 30.2 µM -0.271964254281782 0.413595307644307 no 2010 0.392824752331893 2884 70588
SGTC_1840 st055363 71 µM -0.272541931389508 0.413406258997044 no 2011 0.392602677222319 2906 676033
SGTC_2286 7945697 125 µM -0.272967338615704 0.413267054505282 no 2012 0.392439161229034 2943 1245733
SGTC_525 k781-2675 26.7 µM -0.273908017224637 0.412959278326894 no 2013 0.392077655138276 2892 3651118 YDL195W SEC31
SGTC_999 SEC7.066 22.7 µM -0.274189395400461 0.412867225919499 no 2014 0.391969538600051 2888 740511 YDR170C SEC7
SGTC_1846 st056244 14.8 µM -0.276893264591152 0.41198290450112 no 2015 0.3909310322761 2963 5393182
SGTC_2973 9094665 17.96 µM -0.277152129754676 0.411898264003355 no 2016 0.390831647593935 3109 25237061 YIL048W NEO1
SGTC_2125 5246583 200 µM -0.27803227101646 0.411610517087924 no 2017 0.39049379315743 3025 835267
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.278453726861096 0.411472746231574 no 2018 0.390332040738016 2851 88881 An O-methylated flavonoid and antioxidant.
SGTC_1381 2324-0066 62.1 µM -0.279514627853573 0.411125993753358 no 2019 0.389924956898994 3016 10885928
SGTC_2466 5983409 37.09 µM -0.280440023566893 0.410823587470868 no 2020 0.389569967038645 2931 2879657
SGTC_1857 st056007 79.3 µM -0.282485057509634 0.410155487398481 no 2021 0.388785801305963 2967 619834
SGTC_2054 5233173 129 µM -0.282847534001269 0.410037095691117 no 2022 0.388646857307123 3071 6889
SGTC_149 3970-0822 46.1 µM -0.283038761517859 0.409974640455343 no 2023 0.388573561972552 2907 3114250 YBL034C STU1
SGTC_2756 carbadox 75.1 µM -0.283061024952443 0.409967369327713 no 2024 0.388565028908775 2943 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2938 9059746 27.26 µM -0.283218524971519 0.40991593148472 no 2025 0.388504664300401 3031 6471769
SGTC_3317 9138495 8.753 µM -0.285355328729739 0.409218227478949 no 2026 0.38768596391745 2916 17020139
SGTC_1772 st048439 82.2 µM -0.289032659613328 0.408018188517354 no 2027 0.386278192441818 2999 2927068 YDL195W SEC31
SGTC_2528 xanthyletin 44.79 µM -0.289597296555857 0.407834004240607 no 2028 0.38606216772705 2903 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_363 0455-0021 3.06 µM -0.290815719662492 0.407436624703216 no 2029 0.385596131082405 2898 4597466
SGTC_2062 5245942 200 µM -0.291582447797975 0.40718661087986 no 2030 0.385302948583596 2899 1376160
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.292275816399556 0.406960550601804 no 2031 0.385037873826146 3056 61125 An anti-inflammatory.
SGTC_2704 st078022 71.1 µM -0.292521540805972 0.40688044404262 no 2032 0.384943946291244 3080 54697681
SGTC_1696 st025591 34.7925 µM -0.293363121832193 0.40660611678819 no 2033 0.384622305254198 2921 2787147
SGTC_501 nsc-95397 161 µM -0.293400665364102 0.406593879919838 no 2034 0.384607958465837 3091 262093
SGTC_3033 9090887 49.47 µM -0.294228349548034 0.406324129281096 no 2035 0.384291709547558 2915 19325384
SGTC_2032 5185112 25.99 µM -0.294584020081734 0.406208226308844 no 2036 0.384155835437411 2981 5718189
SGTC_2763 lisinopril 49.32 µM -0.294615591225576 0.406197938562564 no 2037 0.384143775240994 2934 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2735 sertaconazole 140 nM -0.295529384426757 0.405900198773689 no 2038 0.383794754329951 2931 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_978 1416-0512 87.4 µM -0.295717305240456 0.405838975574213 no 2039 0.383722990143561 2996 6814003
SGTC_2876 9059903 25.97 µM -0.295820301272219 0.405805421212185 no 2040 0.383683659170195 2894 6916095
SGTC_1805 st050013 60.3 µM -0.295918856896394 0.405773314107633 no 2041 0.383646024971991 2983 4037144
SGTC_2596 sinensetin 100 µM -0.297902922895684 0.405127087170695 no 2042 0.382888628519221 2971 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2892 9047358 58.44 µM -0.298267509847994 0.40500836621596 no 2043 0.382749499856104 2978 6466771
SGTC_353 1988-1175 58.3 µM -0.298484103263975 0.404937840740282 no 2044 0.382666853615209 2847 2788357
SGTC_2708 st078559 56 µM -0.29850079563343 0.404932405627943 no 2045 0.382660484476234 3019 17250902
SGTC_1047 2043-3044 82 µM -0.301212689700756 0.404049644664718 no 2046 0.381626156969645 2953 669592
SGTC_2748 diazoxide 86.69 µM -0.301627162888799 0.403914770528843 no 2047 0.38146814942833 3011 3019 A potassium channel activatior.
SGTC_43 0570-0105 72.5 µM -0.302460275521918 0.403643701082598 no 2048 0.381150605843739 2941 1114046 YDL195W SEC31
SGTC_1908 st060353 56.5 µM -0.30344019458808 0.403324924535462 no 2049 0.380777208920694 3151 4227716
SGTC_2523 spermine 47.74 µM -0.307224371484526 0.40209450223913 no 2050 0.379336298107426 3061 1103 A DNA binding polyamine.
SGTC_2775 cyproheptadine 69.59 µM -0.307937914976679 0.401862602386737 no 2051 0.379064787350518 3046 2913 A selective serotonin reuptake inhibitor.
SGTC_22 0964-0034 14.468 µM -0.308028111404129 0.401833291231037 no 2052 0.379030470911275 2979 138402
SGTC_867 0518-0118 155 µM -0.310197519724823 0.401128464786801 no 2053 0.378205378272757 3046 6848158
SGTC_89 0302-0250 142.109 µM -0.310386595281225 0.40106705059232 no 2054 0.378133493274943 2936 4203518 YLR208W SEC13
SGTC_377 3970-0964 33.1 µM -0.311497393736852 0.400706298253182 no 2055 0.377711261951576 2948 16481235
SGTC_2243 6634756 200 µM -0.312098501393196 0.400511112713294 no 2056 0.377482832704785 3210 885676
SGTC_1931 st074438 57.1 µM -0.312758505967776 0.40029683138017 no 2057 0.377232071168817 2900 2787313
SGTC_885 0865-0106 16.8 µM -0.314340330072951 0.399783388449577 no 2058 0.376631285220994 2960 2793380
SGTC_1875 nocodazole 6 µM -0.31522917617658 0.399494954615042 no 2059 0.376293827299499 3053 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_825 1988-2224 89.6 µM -0.315879695679728 0.399283893389454 no 2060 0.376046911983117 2954 1180859
SGTC_1422 4031-0024 15.5 µM -0.316771902302456 0.398994464596836 no 2061 0.375708342893422 3023 782427
SGTC_1938 st074717 56.4 µM -0.317552197190897 0.398741385097907 no 2062 0.375412319799461 2898 17250979
SGTC_2861 9024595 19.48 µM -0.319194177639535 0.398208967152207 no 2063 0.374789635900012 3002 16482810
SGTC_639 0833-0042 114 µM -0.320255166978134 0.397865038318671 no 2064 0.374387453152243 3001 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1054 3429-0080 167 µM -0.320433177400398 0.397807342473853 no 2065 0.374319989202866 3160 1162877
SGTC_609 0986-0026 86.3 µM -0.322406211430073 0.397168002527131 no 2066 0.373572489606769 2979 2848610
SGTC_1150 3909-7983 10.9 µM -0.324390046931493 0.396525440966497 no 2067 0.372821377049693 3004 23965914
SGTC_2352 9027995 87.8 µM -0.324536439929457 0.396478035586855 no 2068 0.372765969379234 3023 2997347
SGTC_2585 alliin 100 µM -0.326297079541008 0.395908020537643 no 2069 0.372099798804997 3169 87310 A garlic compound which reacts with lipids.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.326321681526252 0.395900057107105 no 2070 0.372090492894817 3028 66535 A nucleotide analog.
SGTC_1888 azatryptophan 97.5 µM -0.32713331955551 0.395637361914065 no 2071 0.371783525825284 3089 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_879 0831-1030 162 µM -0.327165813482997 0.395626845898464 no 2072 0.371771238094435 2997 1549252
SGTC_1442 4112-3290 3 µM -0.32833561887683 0.395248312232979 no 2073 0.371328957798925 2980 704353
SGTC_3333 9141820 12.094 µM -0.330970316857275 0.394396121005289 no 2074 0.370333453436779 2998 1939433
SGTC_1132 3456-3614 2.5 µM -0.331049666434845 0.394370463256305 no 2075 0.37030348511801 3233 3125502
SGTC_2652 actinonin 100 µM -0.331528696081638 0.394215578377843 no 2076 0.370122584522185 2968 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1833 st055984 71 µM -0.332550146969651 0.39388536807516 no 2077 0.369736940132654 3017 676288
SGTC_2521 angolensin 13.4 µM -0.333436921120733 0.393598757342176 no 2078 0.369402248563181 3152 821428 A flavenoid.
SGTC_535 2293-4129 48.2 µM -0.334209169158232 0.393349209083585 no 2079 0.369110862716503 3160 396118 YIL048W NEO1
SGTC_1703 st026983 48.3 µM -0.33671003345866 0.392541367896755 no 2080 0.368167749500562 3142 1104023
SGTC_877 0771-0151 33.1 µM -0.337609731532367 0.392250856114638 no 2081 0.367828653831529 3076 6166523
SGTC_2486 5283202 22.39 µM -0.337958843242592 0.39213814438598 no 2082 0.367697101555695 3036 1377751
SGTC_1449 4112-4002 201 µM -0.337970426354568 0.392134404899724 no 2083 0.367692737073338 3043 2059539
SGTC_1803 st050068 52.4 µM -0.343014243120021 0.390507012698306 no 2084 0.365793872518369 3101 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_603 3794-0023 45.9 µM -0.344145138450073 0.390142390257511 no 2085 0.365368569098501 3112 3802260
SGTC_196 k015-0023 18.111 µM -0.344584058148849 0.390000900102249 no 2086 0.365203546165971 3008 5211998
SGTC_3346 9158254 43.5805 µM -0.345178531074691 0.389809289046131 no 2087 0.364980078870541 3097 17639500
SGTC_2725 haloperidol 53.21 µM -0.345758182377298 0.389622481091695 no 2088 0.364762227295589 2995 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1425 4048-4433 7.33 µM -0.347104093119634 0.389188824185136 no 2089 0.364256559295059 3108 23734946
SGTC_1062 mesoridazine 14.2 µM -0.350266869814346 0.388170311039589 no 2090 0.363069213180482 3013 4078 A neuroleptic.
SGTC_130 0136-0219 337.655 µM -0.351189326783141 0.387873395481518 no 2091 0.362723158407908 2976 234244
SGTC_1352 1496-0991 99 µM -0.352760036749145 0.38736797459 no 2092 0.362134173068788 3011 3000039
SGTC_2220 6782180 200 µM -0.355183315655767 0.386588589853349 no 2093 0.361226131551752 3096 833803
SGTC_3055 9094636 49.47 µM -0.355898268862188 0.3863587309297 no 2094 0.360958376141442 3211 25236176
SGTC_2079 5212404 121 µM -0.356398395999293 0.386197962725687 no 2095 0.360771115213539 3175 758462
SGTC_1478 0453-0656 35.7 µM -0.356979110526042 0.386011313843854 no 2096 0.360553722097513 3107 5258496
SGTC_483 fpl-64176 144 µM -0.358169676255565 0.38562873372134 no 2097 0.360108169382357 3069 3423
SGTC_1864 st057645 30.4 µM -0.36034812401718 0.384928992724269 no 2098 0.359293407678871 3116 688666
SGTC_364 0083-0097 67.7 µM -0.361388943781424 0.384594802253952 no 2099 0.358904355957483 3163 5207356
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.361856601036148 0.384444672940763 no 2100 0.358729596305965 3056 6708784 An antioxidant flavonoid
SGTC_449 xestospongin c 11.1929 µM -0.363984987414856 0.383761628566329 no 2101 0.357934609948261 3142 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_27 0485-0001 32.618 µM -0.364027414964161 0.383748016327866 no 2102 0.357918768827983 3069 2054479
SGTC_2653 dihydrofissinolide 100 µM -0.364068904933295 0.383734705036574 no 2103 0.357903278007436 3124 6857746
SGTC_1604 st002052 72.4 µM -0.364257739030428 0.383674122833066 no 2104 0.357832777293283 3171 6254834 YHR062C RPP1
SGTC_3178 9107506 49.47 µM -0.365323731139403 0.383332182084049 no 2105 0.357434882955221 3185 8897194
SGTC_2785 7756463 72.73 µM -0.368934747831547 0.382174544606461 no 2106 0.356088181249132 3026 2201551
SGTC_2728 chlorpromazine 9.18 µM -0.369620759018784 0.381954738421526 no 2107 0.355832540699247 3034 2726 A thorazine and dopamine antagonist.
SGTC_2867 9039098 71.43 µM -0.370474360865189 0.381681287317129 no 2108 0.355514538370662 3022 6463460
SGTC_2741 miltefosine 3.04 µM -0.37068114874307 0.38161505175831 no 2109 0.355437516373969 3060 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3273 9137859 49.47 µM -0.372316038606984 0.381091507638682 no 2110 0.354828779271181 3134 2377234
SGTC_2865 9030313 51.95 µM -0.376279659652316 0.379823134073861 no 2111 0.353354499651849 3030 42562754
SGTC_2710 st078562 53.7235 µM -0.377041593601593 0.379579459968129 no 2112 0.353071347411885 3023 17250908
SGTC_124 0136-0217 7.121 µM -0.378494007632079 0.379115095946408 no 2113 0.352531822243162 3246 3976905
SGTC_783 0848-0141 92.7 µM -0.378732862080275 0.379038746376904 no 2114 0.352443123851103 3051 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_856 0433-0016 11.3 µM -0.379078416642705 0.378928298582134 no 2115 0.35231481666572 3151 3911780
SGTC_2868 9035608 32.47 µM -0.379637158615527 0.378749731729483 no 2116 0.352107386844879 3038 6462614
SGTC_664 1222-0054 14.9 µM -0.381222655938637 0.378243167910849 no 2117 0.351519019596117 3088 6813991
SGTC_1688 st021091 57.6 µM -0.381340219426973 0.378205614888429 no 2118 0.351475406729494 3194 3656366
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.382008827419297 0.377992064933047 no 2119 0.351227408487427 3016 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1220 1838-0075 193 µM -0.383500391626466 0.377515801410585 no 2120 0.350674389965847 3096 5529645
SGTC_1127 asiatic acid 681.4 nM -0.386067378171426 0.376696586736176 no 2121 0.349723384458954 3063 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2184 6075246 200 µM -0.386955546239964 0.376413270447724 no 2122 0.3493945590707 3147 2267320
SGTC_1629 st005085 44.9 µM -0.386973357284864 0.376407589591776 no 2123 0.349387966064054 3057 24207091
SGTC_70 0141-0289 43.283 µM -0.388567516925727 0.375899238865829 no 2124 0.348798049903337 3124 352408
SGTC_2135 5326629 150.42 µM -0.388634561586198 0.37587786416169 no 2125 0.348773248132526 3115 5020077
SGTC_171 k064-0041 9.68 µM -0.388795712571111 0.375826488703203 no 2126 0.348713636337536 3092 53325
SGTC_933 2914-0560 114 µM -0.389010991105902 0.375757860640089 no 2127 0.348634007902196 3253 463887
SGTC_1461 k072-0203 53.8 µM -0.391585980924271 0.374937291804648 no 2128 0.347682073966055 3132 5418714
SGTC_3084 9116877 49.47 µM -0.393200085805763 0.374423215230981 no 2129 0.347085853172354 3164 27241325
SGTC_2216 7189485 200 µM -0.393634328086118 0.374284951379731 no 2130 0.346925516542957 3199 731273
SGTC_1656 st012921 11 µM -0.393657774544438 0.37427748642739 no 2131 0.346916860113693 3179 6732821
SGTC_3022 9087993 49.47 µM -0.394081512389172 0.374142583652454 no 2132 0.346760429932208 3186 17173644
SGTC_1948 st076329 66.6 µM -0.394878425472317 0.373888917160295 no 2133 0.346466306405101 3052 24208413
SGTC_1571 st070080 73.4 µM -0.395749732693411 0.373611632664434 no 2134 0.346144831505942 3251 4315245
SGTC_768 0384-0033 77.3 µM -0.395822781628385 0.37358838856778 no 2135 0.346117884622603 3106 3965305 YMR134W ERG29
SGTC_1906 st060206 94.7 µM -0.396777732553935 0.373284566485161 no 2136 0.34576568629762 3219 5133468
SGTC_827 3253-0474 693 µM -0.398109249907657 0.372861069552938 no 2137 0.345274828151174 3221 5402065
SGTC_572 0960-0087 17.7 µM -0.399350589432027 0.372466392550162 no 2138 0.344817447958948 3134 6796365
SGTC_1350 1495-0454 146 µM -0.404995772976044 0.370673232408049 no 2139 0.342740309031027 3267 1069057
SGTC_2316 5844804 197.44 µM -0.406479663628303 0.370202347143637 no 2140 0.342195098192968 3210 776813
SGTC_1137 ixabepilone 100 µM -0.406663008783614 0.370144179432597 no 2141 0.342127756348017 3123 154225 A novel microtubule stabilizer.
SGTC_2909 7941780 10.49 µM -0.407166094086745 0.369984586871074 no 2142 0.341943001190366 3275 1243215
SGTC_1946 st076057 65.1 µM -0.407813063788032 0.36977938311066 no 2143 0.341705460951092 3132 953009
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.40861955652629 0.369523634270244 no 2144 0.34140943827501 3238 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_709 3807-1509 243 µM -0.410414763136405 0.368954559392071 no 2145 0.340750859198124 3184 1886677 YPL242C IQG1
SGTC_3146 9095609 49.47 µM -0.410609211196618 0.368892937179589 no 2146 0.340679554194324 3165 17173999
SGTC_100 0086-0128 49.5915 µM -0.412246615508997 0.368374163913014 no 2147 0.340079336483567 3168 93297
SGTC_1796 st049173 110.4 µM -0.414074253282052 0.367795402925286 no 2148 0.339409863938152 3229 94134
SGTC_2353 9059630 146.67 µM -0.417339884920482 0.366762017879954 no 2149 0.338214909428993 3226 4779114
SGTC_2564 betulinic acid 100 µM -0.419338511076968 0.366130042844161 no 2150 0.337484377609363 3381 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1114 scopoletin 1.73284 µM -0.419375337794834 0.366118401462498 no 2151 0.337470922553145 3253 5280460 A coumarin with genotoxic properties.
SGTC_2452 5863136 48.41 µM -0.419732616545976 0.366005467622711 no 2152 0.337340397526275 3107 2184096
SGTC_101 0490-5701 117.494 µM -0.419973901066197 0.365929205484864 no 2153 0.33725225986681 3218 4661669
SGTC_343 4130-2827 29.8 µM -0.422153023080841 0.365240696634255 no 2154 0.336456663950954 3174 1118244
SGTC_19 0279-0214 38.434 µM -0.424562449493404 0.36447992690552 no 2155 0.335577835796928 3173 3566274 YBR002C RER2
SGTC_110 0850-0284 111.64 µM -0.425349211847092 0.364231624265053 no 2156 0.335291061938725 3053 3906265
SGTC_587 k089-0003 57 µM -0.425437613456953 0.364203728226006 no 2157 0.335258845660191 3220 9659696
SGTC_2808 7946468 45.46 µM -0.42630690443681 0.363929452839591 no 2158 0.334942113731831 3198 2970879
SGTC_1967 st070177 51.4 µM -0.427681136330773 0.363496002641281 no 2159 0.334441642715739 3303 5729214
SGTC_903 1134-0042 114 µM -0.429174119728693 0.363025294703005 no 2160 0.333898257792012 3164 701009
SGTC_2041 5107442 45.335 µM -0.429791155187535 0.36283081607511 no 2161 0.333673783704383 3302 793005
SGTC_3254 9136651 49.47 µM -0.431438540886046 0.362311762752218 no 2162 0.333074765681331 3192 16454030
SGTC_2798 7813637 45.45 µM -0.43361901192903 0.361625135723716 no 2163 0.332282563259919 3284 956368
SGTC_886 0866-0150 153 µM -0.433681461725515 0.361605476926873 no 2164 0.332259885194405 3313 271463
SGTC_2229 7354935 190 µM -0.43608836116136 0.360848079169399 no 2165 0.331386310633257 3238 318112
SGTC_3167 9103034 49.47 µM -0.438506799538603 0.360087599627328 no 2166 0.330509471107267 3256 5127859
SGTC_311 1315-0136 58 µM -0.438980703217463 0.359938645052203 no 2167 0.330337759303596 3340 6759207
SGTC_802 4112-3352 742 µM -0.439500266129317 0.359775363579237 no 2168 0.330149544617238 3304 704594
SGTC_2519 cryptotanshinone 88.04 µM -0.439965277044242 0.359629247697532 no 2169 0.329981128150149 3312 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2647 atorvastatin 60.16 µM -0.439989525118018 0.359621629022526 no 2170 0.32997234698949 3224 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_233 rapamycin 362 pM -0.441730236531201 0.359074848437444 no 2171 0.329342213418334 3265 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_799 1310-0557 151 µM -0.442568203266171 0.35881173477121 no 2172 0.329039043971134 3328 5354492
SGTC_2308 7584454 197.62 µM -0.443069885821708 0.358654243217715 no 2173 0.32885759314884 3375 893577
SGTC_415 dibenzyl ketone 100 µM -0.443098097405958 0.358645387561387 no 2174 0.328847390652419 3236 7593
SGTC_25 0118-0223 35.662 µM -0.443523897487746 0.358511737543749 no 2175 0.328693418911502 3326 5333628
SGTC_2379 9035213 200 µM -0.446029164686933 0.357725736313706 no 2176 0.327788089516474 3316 646551
SGTC_296 1222-0039 74.9 µM -0.446989804673851 0.357424505359392 no 2177 0.327441210594357 3218 5984176
SGTC_1339 1486-1321 22.7 µM -0.44701375698236 0.357416995691445 no 2178 0.327432563521387 3206 3469382
SGTC_400 oxethazaine 37.5 µM -0.447238582252301 0.357346509848791 no 2179 0.327351403394222 3255 4621 A local anesthetic.
SGTC_408 cantharidin 100 µM -0.448220861685733 0.357038608723529 no 2180 0.326996904117395 3211 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_226 1,3-diallylurea 8.28947 mM -0.44891788790669 0.356820178304943 no 2181 0.326745445800349 3258 74537 YKL182W FAS1
SGTC_893 0958-0369 48.9 µM -0.449559220923838 0.356619242188397 no 2182 0.326514148785479 3285 6819948
SGTC_1420 4'-methoxyflavone 42 µM -0.449786085491985 0.356548172749464 no 2183 0.32643234594719 3270 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1527 coumarin 137 µM -0.450466964921226 0.356334904838506 no 2184 0.326186884536582 3336 323 A hepatotoxic, DNA x-linker.
SGTC_1424 4048-1941 275 µM -0.451068554287386 0.356146509872361 no 2185 0.325970070336755 3310 X1424
SGTC_1093 fluphenazine 7.97 µM -0.451314020806131 0.356069649154927 no 2186 0.32588162053017 3214 6602611 An atypical antipsychotic.
SGTC_3087 9117406 49.47 µM -0.451355063839692 0.356056798290564 no 2187 0.325866832306774 3283 42546093
SGTC_2687 chenodiol 100 µM -0.451779885736693 0.355923793155228 no 2188 0.325713780742826 3299 5702181 A cholesterol synthesis inhibitor.
SGTC_2727 riluzole 51.77 µM -0.453748420537121 0.355307704587373 no 2189 0.325004955906864 3263 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_776 4476-4378 112 µM -0.454546978301882 0.355057889162527 no 2190 0.324717593636487 3281 2892008
SGTC_571 k831-0106 44.2 µM -0.454693868628071 0.355011943763495 no 2191 0.324664746272737 3319 4783639
SGTC_322 k048-0136 19.3 µM -0.457233580199863 0.354217888602884 no 2192 0.323751582179584 3275 6823282
SGTC_590 k048-0076 22.4 µM -0.458433864576557 0.353842833115746 no 2193 0.323320383331164 3298 6832814
SGTC_1540 guanosine 70.6 µM -0.461446502811084 0.352902092733155 no 2194 0.322239147292368 3280 6802 Guanosine is a purine nucleoside
SGTC_2075 5212009 200 µM -0.461761803550418 0.352803687307054 no 2195 0.32212607253407 3314 780898
SGTC_1301 naphtanilide LB 4.81 µM -0.462209289677637 0.352664043699571 no 2196 0.321965621040812 3343 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1784 st039334 36.3 µM -0.462489033609148 0.352576756211484 no 2197 0.321865332369053 3399 3496984
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.463270853309893 0.352332849007497 no 2198 0.321585117505701 3235 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2998 9066762 71.4286 µM -0.463667733519179 0.352209056038533 no 2199 0.321442909037919 3395 4945196
SGTC_2625 euphol 100 µM -0.463775997325835 0.352175289629583 no 2200 0.32140412094232 3344 6708538 A triterpene alcohol.
SGTC_181 1447-1644 8.07 µM -0.46417459434313 0.352050981213573 no 2201 0.321261330823892 3288 534600
SGTC_342 k048-0088 23.3 µM -0.465025184424792 0.35178576490683 no 2202 0.320956710781638 3195 6820570
SGTC_2558 carylophyllene oxide 100 µM -0.465657777995399 0.351588567254308 no 2203 0.320730239475304 3325 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2164 5685496 200 µM -0.466378613395719 0.351363910755487 no 2204 0.320472258514177 3344 759046
SGTC_1821 st053465 65.6 µM -0.467110465930709 0.351135873755828 no 2205 0.320210423325383 3270 675086
SGTC_3111 9122088 49.47 µM -0.467553511671566 0.350997851733522 no 2206 0.320051958145526 3213 16876704
SGTC_1236 0330-0013 258 µM -0.46760352796876 0.35098227139286 no 2207 0.320034070763906 3225 4617066
SGTC_1993 st073995 70.8 µM -0.468636452809992 0.350660565897215 no 2208 0.31966475833445 3265 3098394
SGTC_2925 9010536 32.5 µM -0.470094805964202 0.350206542644141 no 2209 0.319143642445738 3243 2994177
SGTC_1292 0kpi-0043 232 µM -0.471074243375503 0.349901738393227 no 2210 0.318793858776685 3278 3333905
SGTC_2405 ticlatone 3.52 µM -0.471748422480842 0.349691987739716 no 2211 0.318553184868257 3021 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_143 4032-1194 15.74 µM -0.471895906003722 0.349646108768091 no 2212 0.318500545207152 3220 1806963
SGTC_2019 4016004 108 µM -0.472708811309057 0.349393270725192 no 2213 0.31821046968405 3274 45595336
SGTC_1076 itraconazole 331 nM -0.472913818157008 0.34932951796359 no 2214 0.318137333036252 3300 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_61 0978-8327 98.565 µM -0.4732859018161 0.349213818733499 no 2215 0.318004609479747 3338 6150059 YHR072W ERG7
SGTC_1813 st051246 8.6015 µM -0.474579761710057 0.348811602778721 no 2216 0.317543267105906 3298 5291959
SGTC_1481 3346-2004 36 µM -0.47532648322835 0.348579550346011 no 2217 0.31727714279602 3326 2770522
SGTC_1158 4092-0494 91.8 µM -0.476930675595771 0.348081220496863 no 2218 0.316705743714224 3367 1148199
SGTC_1337 1486-1011 40.3 µM -0.480093102140634 0.347099606014054 no 2219 0.315580596416412 3345 X1337
SGTC_419 nsc-638432 893 µM -0.480553271857267 0.346956855003351 no 2220 0.315417016501252 3279 368090
SGTC_1926 methyl fluorone black 53.6 µM -0.48068591871292 0.346915710145707 no 2221 0.31536987026199 3227 72721 Reacts with homocysteine.
SGTC_1468 k284-1086 134 µM -0.48149192289766 0.346665739818312 no 2222 0.315083459472949 3282 15996457
SGTC_468 gf-109203x 121 µM -0.48159381248292 0.346634145013701 no 2223 0.315047261271667 3264 2396 A protein kinase C inhibitor.
SGTC_1017 4239-0030 168 µM -0.482866550623478 0.346239573301304 no 2224 0.31459524674599 3245 1149593
SGTC_755 1995-0008 37.3 µM -0.484499846198592 0.345733466762731 no 2225 0.314015586736389 3349 689533
SGTC_681 1642-0006 26.6 µM -0.484694652485198 0.345673120844158 no 2226 0.313946480161172 3348 4446530
SGTC_2733 amorolfine 100 µM -0.486359783518238 0.345157466717763 no 2227 0.313356049540258 3315 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2415 st077333 57.7 µM -0.486915943962888 0.344985300141471 no 2228 0.313158949765006 3448 2766255
SGTC_1194 1488-0194 225 µM -0.489441311579768 0.344203944401703 no 2229 0.312264647340831 3232 1391452
SGTC_3267 9137951 49.47 µM -0.490190678950921 0.34397221577478 no 2230 0.31199948799777 3218 16643986
SGTC_1676 st018489 23.4 µM -0.491557095056238 0.343549826593461 no 2231 0.31151624026284 3273 3696235
SGTC_379 3970-0972 5.9 µM -0.492567493500267 0.343237615832102 no 2232 0.311159110636484 3323 2898042 YBL034C STU1
SGTC_401 neomycin 50 µM -0.492568820860292 0.343237205751258 no 2233 0.311158641592251 3293 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_173 1273-0061 2.693 µM -0.495722876509556 0.342263299270636 no 2234 0.310044972306988 3329 2847414 YPL266W DIM1
SGTC_2354 9060492 162 µM -0.495803010899158 0.342238569072208 no 2235 0.310016700188298 3380 6471895
SGTC_175 3793-3120 23.7 µM -0.496103350797266 0.342145887479841 no 2236 0.309910747621369 3242 5322297
SGTC_77 0828-0286 12.516 µM -0.497057536803182 0.341851499278687 no 2237 0.30957423892349 3360 745345
SGTC_305 1682-2595 20.8 µM -0.498091477462129 0.341532613469297 no 2238 0.309209783626536 3341 226033
SGTC_93 0109-0045 59.227 µM -0.498566014362346 0.341386295639408 no 2239 0.309042576207516 3385 88733
SGTC_1808 st050063 61.5 µM -0.49944610674854 0.341114992698423 no 2240 0.308732572330285 3386 4011993
SGTC_2258 7960471 200 µM -0.501190417822628 0.340577522928683 no 2241 0.308118558687943 3309 2974708
SGTC_909 3448-9333 149 µM -0.503587845637797 0.339839338213448 no 2242 0.307275517710538 3270 3344074
SGTC_1485 3909-9022 254 µM -0.504799850350641 0.339466386901914 no 2243 0.306849710469484 3372 714516
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.505252070519298 0.339327272481943 no 2244 0.306690901026746 3581 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2107 5363541 170.161 µM -0.507025529009972 0.338781923025904 no 2245 0.306068453085931 3376 244052
SGTC_463 ikarugamyin 104 µM -0.508488047276837 0.338332443676962 no 2246 0.305555559703584 3363 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2904 7225135 42.03 µM -0.508773199791769 0.338244833856301 no 2247 0.305455603404038 3412 4446116
SGTC_1798 st045719 60.953 µM -0.509789050625093 0.337932796603924 no 2248 0.305099628724842 3346 3980186
SGTC_2428 5615643 7.78 µM -0.510165691003781 0.337817132869706 no 2249 0.304967693137005 3365 2253075
SGTC_96 0929-0093 37.281 µM -0.511797428140164 0.337316214341128 no 2250 0.304396395253017 3301 6991579
SGTC_1045 1348-1485 165 µM -0.513067604525242 0.33692648891559 no 2251 0.303952015751269 3347 6810614
SGTC_2000 st075254 36.4 µM -0.514516846182989 0.336482035043429 no 2252 0.303445342722985 3370 17234175
SGTC_2539 epi(13)torulosol 80 µM -0.515736489106379 0.336108171510659 no 2253 0.303019232910626 3374 6708597
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.516598379383647 0.335844069473277 no 2254 0.30271827362015 3328 65057 A dermal irritant. YDR527W RBA50
SGTC_1650 st011916 45.8 µM -0.517291239571289 0.335631820706895 no 2255 0.302476434257871 3425 242528
SGTC_576 1073-0113 22.7 µM -0.519193851342286 0.335049250013698 no 2256 0.301812783180109 3500 5439563
SGTC_3298 9116858 71.43 µM -0.522465496309891 0.334048415808971 no 2257 0.300673131953711 3415 2506942
SGTC_1897 st060201 15 µM -0.523148020266729 0.333839772206362 no 2258 0.300435625302669 3349 611878
SGTC_2483 5729050 27.16 µM -0.525728477807705 0.333051405970907 no 2259 0.299538437210104 3470 2865180
SGTC_158 k038-0087 26.446 µM -0.527349110967337 0.332556656312056 no 2260 0.29897558784891 3310 X158
SGTC_950 1165-0508 94.1 µM -0.527377454845035 0.332548006036185 no 2261 0.298965748234707 3374 6148369
SGTC_1572 epiandrosterone 68.9 µM -0.52855201108584 0.332189621348877 no 2262 0.298558128900882 3376 441302 A steroid.
SGTC_630 4356-0227 183 µM -0.529919774526941 0.331772477961969 no 2263 0.298083777568061 3404 779312
SGTC_2459 5811157 9.22 µM -0.53142802318624 0.331312730806116 no 2264 0.297561103311484 3407 2870684 YBR192W RIM2
SGTC_1921 5740136 50 µM -0.53246071735201 0.330998089568599 no 2265 0.297203471002197 3444 1774243
SGTC_546 peri-Naphthalide 147 µM -0.533503040368172 0.330680635602461 no 2266 0.296842703481686 3326 223824 A penicillin ester.
SGTC_1717 st033143 58.0435 µM -0.533827306340641 0.330581900712224 no 2267 0.296730509843956 3470 674616
SGTC_2606 farnesol 9.78 µM -0.535428515803078 0.330094525615861 no 2268 0.296176788026796 3466 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3276 9139060 49.47 µM -0.53609602556021 0.3298914344935 no 2269 0.295946093404205 3426 4870619
SGTC_3046 9092212 49.47 µM -0.536129856240343 0.329881142778583 no 2270 0.29593440355342 3397 25236637
SGTC_3245 9134821 49.47 µM -0.536435776321543 0.329788083921778 no 2271 0.295828705578938 3344 17014901
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.541155272325589 0.328353782524216 no 2272 0.294200281841455 3446 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2265 7929201 200 µM -0.543227398733248 0.327724839623153 no 2273 0.293486622149079 3306 1265108
SGTC_81 0411-0046 9.971 µM -0.543901365190708 0.327520378894499 no 2274 0.293254674736028 3369 12925265
SGTC_3053 9095903 49.47 µM -0.544299295356398 0.327399683379357 no 2275 0.293117765882151 3449 17174018
SGTC_1168 k815-0004 80.5 µM -0.545219742144379 0.327120573385501 no 2276 0.292801197534504 3343 642433
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.547485380454012 0.326433968729995 no 2277 0.292022655823312 3448 279621
SGTC_1366 1683-0113 21.9 µM -0.548219649557051 0.326211573492223 no 2278 0.29177054573543 3389 708623
SGTC_2661 dactinomycin 12.96 µM -0.54839055702464 0.326159817943586 no 2279 0.291711879491088 3396 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1065 prochlorperazine maleate 2.48 µM -0.54881439148917 0.326031483493187 no 2280 0.291566416442998 3477 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2368 9071271 200 µM -0.551725218207177 0.325150660524062 no 2281 0.290568314711041 3373 27209959
SGTC_554 4483-2211 187 µM -0.552922180047843 0.3247887400181 no 2282 0.290158349413116 3415 747107
SGTC_2941 9056145 11.23 µM -0.553121190833688 0.324728581953293 no 2283 0.290090213529696 3416 2119517
SGTC_1029 k015-0030 64.7 µM -0.553207690207064 0.324702435876568 no 2284 0.29006060083373 3435 2208316
SGTC_1409 3909-8004 61.9 µM -0.554519872993701 0.324305909732019 no 2285 0.289611554465837 3410 2119279
SGTC_2846 9008642 19.48 µM -0.555424420998163 0.324032681941363 no 2286 0.289302196281686 3451 2992898
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.555557329864068 0.323992543467997 no 2287 0.289256754131863 3390 15053
SGTC_2055 5235184 200 µM -0.557070995715467 0.32353556087851 no 2288 0.288739461682407 3468 2836034
SGTC_747 3448-8087 38.7 µM -0.557491048045654 0.323408792297505 no 2289 0.288595986841914 3397 5168703
SGTC_729 4092-0585 94.1 µM -0.557909419396632 0.323282551396489 no 2290 0.288453119556683 3371 2169061
SGTC_998 3996-0085 177 µM -0.559066222699453 0.32293359927435 no 2291 0.288058262897129 3395 715391
SGTC_772 k072-0172 35.3 µM -0.559429127912061 0.322824160255428 no 2292 0.287934443483831 3374 5861980
SGTC_3136 9095672 49.47 µM -0.560547637603728 0.322486954939471 no 2293 0.287552977995946 3365 17217380
SGTC_1457 k015-0032 57.3 µM -0.562827269336062 0.321800149817165 no 2294 0.286776254746282 3460 4302660
SGTC_551 k048-0028 34.9 µM -0.563825800527567 0.321499504826568 no 2295 0.286436345575662 3498 6836383
SGTC_1843 st055809 45.5 µM -0.565010503716766 0.321142957437405 no 2296 0.286033309913129 3461 16413835
SGTC_3260 9137109 49.47 µM -0.565963748393296 0.320856189268506 no 2297 0.285709212149346 3380 17478346
SGTC_1202 1988-0068 29.6 µM -0.567429098349673 0.320415570956447 no 2298 0.285211342467906 3364 2850480
SGTC_2635 hydroquinidine 100 µM -0.567976664081664 0.320250987486695 no 2299 0.285025406809638 3447 442912 An experimental heart treatment.
SGTC_2605 digitonin 300 nM -0.568346737538606 0.320139773420779 no 2300 0.284899774542877 3553 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_941 3237-0776 460 µM -0.568832030592744 0.3199939581764 no 2301 0.284735067654496 3503 760008
SGTC_700 3453-2283 142 µM -0.569801394743342 0.319702778101403 no 2302 0.284406204729572 3526 565664
SGTC_350 k064-0020 19.8 µM -0.570266863403828 0.319562998905881 no 2303 0.284248356061571 3487 2790705
SGTC_642 0335-0876 158 µM -0.570294329094498 0.319554751821144 no 2304 0.284239043268059 3464 6812350
SGTC_738 1315-0003 72.4 µM -0.570548823431846 0.319478339405259 no 2305 0.284152758795036 3497 6251474
SGTC_1738 st035555 74 µM -0.570554391439578 0.319476667685863 no 2306 0.284150871142127 3464 5331140
SGTC_2359 9039622 200 µM -0.573503496392572 0.318591754906187 no 2307 0.283151916210462 3444 6463596
SGTC_597 k018-0003 82.8 µM -0.575086020269032 0.318117326271012 no 2308 0.282616561036146 3513 6786234
SGTC_2421 5690543 90.72 µM -0.575268735799638 0.318062568735839 no 2309 0.282554781176009 3478 3397993
SGTC_2534 helenine 20.12 µM -0.576976398149702 0.317550996311284 no 2310 0.281977699709103 3466 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_204 PMA1.184 62.41 µM -0.579057936537094 0.316927891035489 no 2311 0.28127504055295 3472 2252213 YGL008C PMA1
SGTC_677 0929-0063 136 µM -0.579582532307539 0.316770935901459 no 2312 0.28109808767035 3451 1539583
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.579780922677664 0.316711587577471 no 2313 0.281031182070454 3479 688669
SGTC_50 0929-0078 56.389 µM -0.580938264854806 0.316365463641733 no 2314 0.280641030919976 3339 1377751
SGTC_2241 6772625 37.8075 µM -0.58278273230216 0.315814175001909 no 2315 0.280019785365557 3471 2285411
SGTC_967 1306-0166 352 µM -0.583196285722177 0.315690625123445 no 2316 0.279880585640285 3503 4437607
SGTC_1448 4255-0083 152 µM -0.584006551472755 0.315448616386408 no 2317 0.279607952134979 3542 5399660
SGTC_184 1494-0393 24.714 µM -0.584077648622636 0.315427384991323 no 2318 0.279584035933169 3440 3090647
SGTC_1302 1159-0335 255 µM -0.584744108704435 0.315228392905289 no 2319 0.279359895304234 3466 649284
SGTC_2083 5306046 65.942 µM -0.584774418291296 0.315219344322836 no 2320 0.279349703806378 3497 539837
SGTC_762 1165-0429 115 µM -0.584897588994594 0.315182574250777 no 2321 0.279308289925327 3489 5967793
SGTC_1203 3992-3522 103 µM -0.585069578533564 0.315131233386014 no 2322 0.279250466601288 3666 5322312
SGTC_1920 st075728 45.7 µM -0.585909667005788 0.314880508603322 no 2323 0.278968110340804 3534 3400306
SGTC_3255 9139072 49.47 µM -0.586315873943369 0.31475930654483 no 2324 0.278831632795115 3514 17646060
SGTC_1692 fluoroquinolonic acid 71 µM -0.586467868348032 0.314713960319522 no 2325 0.278780574017997 3503 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1156 4092-0367 4.88 µM -0.586809387682456 0.314612081151953 no 2326 0.278665865610968 3467 1357585
SGTC_2174 5790901 200 µM -0.587144474212963 0.314512134680468 no 2327 0.278553340173885 3481 786020
SGTC_1957 st077035 62.4 µM -0.587508157935015 0.314403673888198 no 2328 0.278431236562632 3555 705593
SGTC_574 1315-0397 40 µM -0.587686342117467 0.314350540161699 no 2329 0.278371422311248 3535 6794277
SGTC_1865 st057639 52.2 µM -0.58815005942432 0.314212279765573 no 2330 0.278215787443937 3497 688818
SGTC_806 3966-4455 5.86 µM -0.589055492373112 0.31394239406304 no 2331 0.277912024363671 3412 714982
SGTC_3251 9135047 49.47 µM -0.592127757154947 0.313027375136286 no 2332 0.276882520520378 3483 17682963
SGTC_2488 5268135 45.7 µM -0.592674154456122 0.312864760837821 no 2333 0.276699620735091 3484 1270356 YLR208W SEC13
SGTC_1902 st060212 70.5 µM -0.597920093093531 0.311305363910478 no 2334 0.274946626042971 3542 688944
SGTC_2130 NSC 7 2.4545 µM -0.599240901331761 0.310913274712517 no 2335 0.274506125691081 3505 21448
SGTC_3158 9100007 49.47 µM -0.600620554025968 0.310503946323646 no 2336 0.274046372385857 3460 19297233
SGTC_1612 st002233 45.4 µM -0.602874590441429 0.30983570225488 no 2337 0.273296060392023 3543 1035021
SGTC_2071 5230951 39.92 µM -0.603339106640878 0.30969806717741 no 2338 0.273141561185838 3568 1799272
SGTC_2896 9052656 71.43 µM -0.604881795430714 0.309241163553207 no 2339 0.272628769944338 3494 6469436
SGTC_711 k292-0785 179 µM -0.605535285078412 0.309047706059489 no 2340 0.272411693524101 3553 4146315
SGTC_2349 9023730 187.07 µM -0.611082901306162 0.307407540093458 no 2341 0.270572349481405 3540 4126287
SGTC_1756 st041558 35.5 µM -0.611450103295347 0.307299111235872 no 2342 0.270450820815205 3619 3955792
SGTC_26 0302-0163 425.158 µM -0.611859402685834 0.307178271539721 no 2343 0.270315391805645 3507 3100915
SGTC_1480 1070-0044 41.2 µM -0.612582111903443 0.30696495327246 no 2344 0.270076344544449 3518 3124987
SGTC_1018 4259-0013 28.1 µM -0.613670335902414 0.306643871200802 no 2345 0.26971659724449 3529 6801262
SGTC_32 0928-0142 34.1 µM -0.614800377294645 0.306310607830755 no 2346 0.269343280052725 3521 2244242
SGTC_1737 st035557 69.7 µM -0.614984717436117 0.306256258801256 no 2347 0.269282406567999 3474 5716916
SGTC_3156 9099931 49.47 µM -0.615233628190615 0.306182879173534 no 2348 0.269200221286035 3512 18111053
SGTC_1987 st072290 61.9 µM -0.61665343157021 0.305764465661502 no 2349 0.2687316717288 3484 54697379
SGTC_426 0988-0037 14.6 µM -0.616670919229761 0.305759313658502 no 2350 0.268725903178442 3573 5383008
SGTC_259 usnic acid 108.925 µM -0.617544752771751 0.305501924350194 no 2351 0.268437736139423 3614 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3161 9100388 49.47 µM -0.619360592600221 0.304967372760823 no 2352 0.267839417841648 3569 25236368
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.619678749395689 0.304873755737124 no 2353 0.267734654545643 3668 5282309
SGTC_2402 5553605 200 µM -0.620427199004939 0.304653576254167 no 2354 0.267488285034612 3600 6758546
SGTC_1782 st039423 80.636 µM -0.621543543561277 0.304325300623888 no 2355 0.267121026939711 3472 2068169
SGTC_1066 ketoconazole 628 nM -0.622425494709102 0.304066062849556 no 2356 0.266831060340149 3589 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2551 apiole 73.87 µM -0.623343209385937 0.303796417406131 no 2357 0.266529504405535 3458 10659 A possible DNA adduct former.
SGTC_1915 st067105 30.6 µM -0.623879197276834 0.303638981340688 no 2358 0.26635346153249 3566 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1190 1486-1332 13 µM -0.624320564949161 0.303509365484361 no 2359 0.266208540443093 3536 4150046
SGTC_1771 st048882 4.1505 µM -0.624439633136324 0.303474403121449 no 2360 0.266169451777486 3448 4580403
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.625163484218191 0.303261895196471 no 2361 0.265931882650333 3476 641818 YHR062C RPP1
SGTC_2318 6029776 164 µM -0.62545358101833 0.303176747365209 no 2362 0.265836702563781 3590 818325
SGTC_1740 st038286 13.222 µM -0.625678739401033 0.303110667319034 no 2363 0.26576284052349 3571 716786
SGTC_1652 st011932 78 µM -0.625751549567282 0.303089300187611 no 2364 0.265738957752083 3537 1551076
SGTC_2231 micatex 6.853 µM -0.626058448142031 0.302999244042289 no 2365 0.265638302609127 3562 20737 An antifungal of unknown mechanism.
SGTC_1316 1272-0050 65.9 µM -0.628503569885263 0.302282177053201 no 2366 0.264837054396923 3567 7340392
SGTC_2929 9013348 24.6 µM -0.628609671235696 0.302251078554975 no 2367 0.264802313606005 3546 2995952
SGTC_237 nikkomycin 200 µM -0.629024878285482 0.302129394420126 no 2368 0.264666384537999 3600 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2826 7992541 19.48 µM -0.629071977680403 0.302115592456975 no 2369 0.264650967540128 3608 2985066
SGTC_2025 5147754 141 µM -0.630909106313765 0.301577462996367 no 2370 0.264049978651125 3571 315777 YLR208W SEC13
SGTC_1371 2421-0008 32.7 µM -0.635578992755174 0.300211510770653 no 2371 0.26252543264606 3557 2827552
SGTC_2492 derrusnin 100 µM -0.635818521252122 0.300141523624447 no 2372 0.262447357060314 3525 1715307 Part of coumarin class of compounds.
SGTC_1162 k048-0130 20.1 µM -0.636478243394043 0.299948799458317 no 2373 0.262232378603311 3568 6797406
SGTC_464 bw-b 70c 158 µM -0.637331207933296 0.299699706574397 no 2374 0.261954563552117 3600 5353454
SGTC_1224 0823-0416 294 µM -0.637420422780173 0.299673658403773 no 2375 0.2619255145256 3604 3598164
SGTC_2926 9010726 65.15 µM -0.637785560576214 0.299567059354208 no 2376 0.261806640124625 3562 2994293
SGTC_2583 asiatic acid 100 µM -0.638621027903314 0.299323216039244 no 2377 0.261534749201312 3605 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1780 st038448 24.544 µM -0.640044948512617 0.298907831678062 no 2378 0.261071688837745 3607 728868 YDL195W SEC31
SGTC_215 1287-0124 461.5 µM -0.640155907728162 0.298875473793603 no 2379 0.261035622502313 3565 5560863
SGTC_2317 5986382 200 µM -0.641505076996792 0.298482156948911 no 2380 0.260597291697439 3629 877883
SGTC_2145 5634607 200 µM -0.642332832269676 0.298240962050339 no 2381 0.260328550446464 3553 308662
SGTC_3252 9135871 49.47 µM -0.643485777446727 0.297905159903899 no 2382 0.259954470244488 3601 17682838
SGTC_3051 9093778 49.47 µM -0.643595223633235 0.297873292011155 no 2383 0.25991897416478 3589 17217378
SGTC_718 1130-0073 349 µM -0.6442602359635 0.297679691083584 no 2384 0.259703348131964 3659 6740020
SGTC_458 nppb 133 µM -0.64445666492917 0.297622516919756 no 2385 0.259639674952613 3630 4549 A chloride channel blocker.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.645176806962694 0.297412949581313 no 2386 0.25940630718662 3595 442882
SGTC_1487 3970-0795 2.82 µM -0.645638383312123 0.297278662467584 no 2387 0.259256786694048 3611 3765103
SGTC_1471 k673-0312 37 µM -0.647150410319118 0.296838960300038 no 2388 0.258767301129387 3582 24099884
SGTC_3058 9093861 49.47 µM -0.647425059112218 0.29675912352979 no 2389 0.258678440967025 3626 17217477
SGTC_2078 5212016 200 µM -0.6476894148574 0.296682288098445 no 2390 0.25859292595043 3531 1899708
SGTC_2261 9010538 184.68 µM -0.648173196600538 0.296541699737067 no 2391 0.258436467914384 3544 6457250
SGTC_1276 0871-0068 94.2 µM -0.648391420542918 0.296478293225036 no 2392 0.258365908981787 3551 3414906
SGTC_2228 7354201 200 µM -0.648720853809861 0.296382585827244 no 2393 0.258259411351101 3618 753451
SGTC_2962 9082311 13.18 µM -0.649302276001985 0.29621370483383 no 2394 0.258071507460764 3564 16459453
SGTC_2253 7938677 135.83 µM -0.649690150229116 0.296101066701475 no 2395 0.257946193794045 3635 2301972
SGTC_1868 st057644 42.7 µM -0.650093218735199 0.295984037001453 no 2396 0.257816004643144 3582 688665
SGTC_2947 9072639 7.68 µM -0.654101996678987 0.294821258284242 no 2397 0.25652304759608 3611 16488146
SGTC_372 0155-0182 15.9 µM -0.654876932262472 0.29459672500919 no 2398 0.256273496639094 3589 771486
SGTC_712 r015-0009 80.6 µM -0.654893319896475 0.294591977635321 no 2399 0.256268220728817 3580 6813872 YLR060W FRS1
SGTC_2240 6690706 185.951 µM -0.655487932901307 0.29441974661617 no 2400 0.25607682658886 3542 805876
SGTC_567 1080-0542 68.4 µM -0.655508530600247 0.294413781278587 no 2401 0.256070197934187 3557 5950415
SGTC_636 0kpi-0074 126 µM -0.656640332947643 0.294086083717519 no 2402 0.255706104236724 3583 616434
SGTC_220 paclitaxel 373.376 µM -0.657557620532789 0.293820619655588 no 2403 0.255411217024274 3580 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_298 1391-0729 10 µM -0.658603758304954 0.29351800158547 no 2404 0.255075124432299 3587 3237558
SGTC_114 0364-0001 490.298 µM -0.658766545437645 0.293470924853094 no 2405 0.255022846631898 3597 4003655
SGTC_1679 SEC14.276 6.7 µM -0.659565130847848 0.293240031039524 no 2406 0.254766468463203 3628 1005053 YMR079W SEC14
SGTC_1927 st060202 13.8 µM -0.660455064540304 0.292982825090404 no 2407 0.254480922861889 3600 688887
SGTC_1401 3807-4679 7.6 µM -0.660479759180135 0.292975689413006 no 2408 0.254473001690679 3603 3291456
SGTC_236 1509-0011 5.31 µM -0.662469586705662 0.292400980983014 no 2409 0.253835159918942 3695 3107280
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.663726861589005 0.292038121215017 no 2410 0.253432571933961 3620 115019
SGTC_671 0560-0003 407 µM -0.664417880028506 0.291838776976253 no 2411 0.253211446103633 3560 3238678
SGTC_2326 6164455 177.58 µM -0.666226176278943 0.291317421875057 no 2412 0.252633271981226 3607 2888790
SGTC_2922 7999257 32.47 µM -0.66669282009579 0.291182953043112 no 2413 0.252484182958987 3611 2988377
SGTC_913 3487-1245 167 µM -0.666781167873874 0.291157497868633 no 2414 0.252455961760739 3582 4016153
SGTC_819 1013-0258 27.7 µM -0.667143908985617 0.291052994098547 no 2415 0.252340107695714 3644 5753198
SGTC_3129 9127257 49.47 µM -0.667528548575769 0.290942200637924 no 2416 0.25221729020862 3523 837894
SGTC_769 0302-0231 76 µM -0.669022864736038 0.290511957660431 no 2417 0.251740446315825 3634 571869 YER009W NTF2
SGTC_355 1311-2252 105 µM -0.669032976694681 0.290509047243442 no 2418 0.251737221160748 3591 5338538
SGTC_1120 ficusin 1.78878 µM -0.670994530939941 0.289944732292345 no 2419 0.25111200679036 3664 6199 A DNA cross-linker.
SGTC_2878 9043973 25.97 µM -0.672169486336794 0.289606958469249 no 2420 0.250737902090725 3661 6465167
SGTC_1218 1348-1416 30.7 µM -0.672808582073928 0.289423310108401 no 2421 0.250534538599818 3630 6787668
SGTC_539 4859-0462 2.54 µM -0.674349117480646 0.288980852150502 no 2422 0.25004469190177 3636 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1118 chelidonine 707.474 nM -0.677583693410969 0.288052884953757 no 2423 0.249017844051003 3655 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3193 9111931 49.47 µM -0.679904432195467 0.287387956132322 no 2424 0.248282487525779 3678 17087244
SGTC_2970 9090938 41.86 µM -0.680422540423462 0.287239609029454 no 2425 0.248118476372794 3649 17217104
SGTC_1708 st033234 31.827 µM -0.680929636292638 0.287094450138572 no 2426 0.247958007245749 3702 674664
SGTC_95 0471-0001 561.058 µM -0.681942833888892 0.286804521016359 no 2427 0.247637549535507 3587 4015405
SGTC_318 1488-0629 67.2 µM -0.68212650467939 0.286751978005283 no 2428 0.247579481183822 3653 3662576
SGTC_840 0245-0196 390 µM -0.682821203918421 0.286553285510422 no 2429 0.247359914677333 3699 3827528
SGTC_47 0149-0135 24.25 µM -0.68608447073033 0.285620826231366 no 2430 0.246329921507634 3613 5239155
SGTC_2793 7325131 81.82 µM -0.687917401044611 0.285097711247455 no 2431 0.24575239896313 3638 4176441
SGTC_1861 st057647 17.4 µM -0.688241122298459 0.285005369266103 no 2432 0.245650475950802 3684 688668
SGTC_520 3584-0023 682 µM -0.688999450375411 0.284789110880055 no 2433 0.245411806721384 3647 1340790
SGTC_127 0180-0333 59.125 µM -0.692037207814077 0.283923595710873 no 2434 0.244456981488277 3635 771601
SGTC_1142 3253-1408 9.78 µM -0.692539934616426 0.283780480730213 no 2435 0.24429915809963 3646 256655
SGTC_1714 st033236 13.627 µM -0.695199649453034 0.283023895238385 no 2436 0.243465095998353 3701 2916566
SGTC_2274 7947094 46.08 µM -0.69582278500242 0.282846777492642 no 2437 0.243269909090329 3663 2971028
SGTC_2193 5925765 200 µM -0.697104628132099 0.282482598621717 no 2438 0.242868659019684 3664 877370
SGTC_3306 9127676 59.7925 µM -0.699037437344376 0.28193390330084 no 2439 0.242264317433794 3681 41905287
SGTC_2188 6126565 140.678 µM -0.699460728286617 0.281813805970526 no 2440 0.242132073715299 3629 874518
SGTC_930 2810-3379 265 µM -0.699897889506329 0.28168979921088 no 2441 0.241995537765838 3703 1015764
SGTC_1886 st057356 49.9 µM -0.700516371440291 0.281514403302205 no 2442 0.241802442354144 3658 24207747
SGTC_3282 9108498 15.4605 µM -0.702164445751058 0.281047281673494 no 2443 0.241288307791684 3662 16459645
SGTC_266 formosanin C 406 nM -0.702502404932168 0.280951538568172 no 2444 0.241182951225414 3658 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_647 0140-0236 81 µM -0.702706854932184 0.280893625978768 no 2445 0.241119227415178 3678 990837
SGTC_1244 0416-0015 52.5 µM -0.703036515858324 0.280800258247389 no 2446 0.241016496634027 3692 96201
SGTC_584 0986-0246 15.4 µM -0.704735615385122 0.280319271419848 no 2447 0.240487391417554 3770 53315 YDR232W HEM1
SGTC_2098 5376439 882.5 nM -0.705171791156181 0.280195861703665 no 2448 0.240351666943097 3726 2844116
SGTC_297 0986-0032 24 µM -0.705314329997728 0.280155538077884 no 2449 0.240307322291154 3670 2847425
SGTC_2251 lansoprazole 556 µM -0.70682159028644 0.27972931278394 no 2450 0.239838677858936 3609 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_750 4073-0104 132 µM -0.708460279749851 0.279266279048106 no 2451 0.239329735046142 3559 22330957
SGTC_160 3453-0671 289.699 µM -0.708754307032499 0.27918323711504 no 2452 0.239238478760117 3697 5322268
SGTC_1253 0550-0034 176 µM -0.710051177830016 0.278817106038994 no 2453 0.238836200165734 3659 5969915
SGTC_2401 5128683 200 µM -0.710696787804491 0.278634925332718 no 2454 0.238636075314645 3654 708373
SGTC_1534 6-azauridine 81.6 µM -0.714923395364945 0.27744367896118 no 2455 0.237328189876814 3738 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3239 9133757 49.47 µM -0.715133120848503 0.277384633865982 no 2456 0.237263394891362 3695 17036923
SGTC_365 0121-0052 13.6 µM -0.715864323778023 0.277178822603288 no 2457 0.237037564717955 3719 3101739
SGTC_2855 9016525 58.44 µM -0.716254087904453 0.277069146455896 no 2458 0.236917235337141 3714 43811474
SGTC_675 1309-0189 238 µM -0.718126528432511 0.276542554699369 no 2459 0.236339637189283 3712 4246530
SGTC_145 3737-0113 38.366 µM -0.722077066510914 0.27543314588386 no 2460 0.235123548584859 3731 6849351
SGTC_952 1185-0122 232 µM -0.722554648226223 0.275299177621913 no 2461 0.234976769792406 3680 678600
SGTC_570 0987-0065 62.6 µM -0.722876883231674 0.27520880437935 no 2462 0.234877763487339 3578 3104428
SGTC_1227 3909-8010 46.6 µM -0.723035011243532 0.275164461526326 no 2463 0.234829187286218 3699 15982272
SGTC_1879 gemcitabine 100 µM -0.723494931036416 0.275035509084705 no 2464 0.234687933600348 3718 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1594 piperine 70.1 µM -0.724358876447504 0.274793356335987 no 2465 0.234422719889711 3706 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.724717960540719 0.274692740628465 no 2466 0.23431253716644 3660 107982 A Capsaicinoid.
SGTC_41 0478-0632 82.643 µM -0.725114627224738 0.27458161536592 no 2467 0.234190855786539 3699 3750424
SGTC_314 1671-0008 2.74 µM -0.725481014525281 0.274478992509014 no 2468 0.234078493992188 3655 3913060
SGTC_2068 5226020 147 µM -0.726312793511387 0.274246086548121 no 2469 0.23382351910483 3762 1810509
SGTC_1773 st048542 73.5835 µM -0.728257318706125 0.273701982213814 no 2470 0.233228042127724 3682 3237138
SGTC_997 3996-0078 137 µM -0.730170031331526 0.273167300953116 no 2471 0.232643129290635 3777 735687
SGTC_2496 diffractaic acid 79.83 µM -0.730228180624898 0.273151053961858 no 2472 0.232625359855989 3759 94870 An apoptosis inducer which activates caspases.
SGTC_2931 9014674 55.67 µM -0.731113957996091 0.272903625783447 no 2473 0.232354774664158 3741 2996810
SGTC_485 niflumic acid 177 µM -0.732330676145223 0.272563935725582 no 2474 0.231983380054641 3747 4488 A COX2 inhibitor.
SGTC_2254 7938975 95.19 µM -0.732533793761078 0.272507248686072 no 2475 0.231921412051324 3762 2969277
SGTC_1469 k284-2957 126 µM -0.73311304407949 0.272345620884145 no 2476 0.23174474249193 3734 23884841
SGTC_623 k072-0108 16.9 µM -0.734225092062735 0.272035460467304 no 2477 0.231405781539368 3732 5382803
SGTC_975 1335-0046 28.5 µM -0.735700005328495 0.271624364736181 no 2478 0.230956643213695 3733 16486740
SGTC_1014 4130-3005 69.3 µM -0.738928910614002 0.270725468125788 no 2479 0.229975082959782 3748 743608
SGTC_3237 9133362 49.47 µM -0.739304634513363 0.270620966706816 no 2480 0.229861017872582 3679 43845137
SGTC_3196 9111891 49.47 µM -0.740229431116093 0.270363835605735 no 2481 0.229580396131983 3743 18891510
SGTC_2319 6033012 152.6 µM -0.742230247007304 0.269807945585982 no 2482 0.228973922727604 3715 847246
SGTC_2828 7998861 71.43 µM -0.743258548315709 0.26952247372598 no 2483 0.22866258124284 3640 2988188
SGTC_670 4204-0025 119 µM -0.743997818579044 0.269317334788774 no 2484 0.228438897411395 3769 719039
SGTC_944 3370-0224 231 µM -0.744129753717678 0.269280732550905 no 2485 0.2283989902243 3771 4580514
SGTC_1077 5-fluorocytosine 377 nM -0.744252191908998 0.269246767245219 no 2486 0.228361959138876 3773 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1817 st052116 64.4 µM -0.745661836921254 0.268855875616672 no 2487 0.227935859104748 3741 4361398
SGTC_3213 9129884 49.47 µM -0.746391549641522 0.268653639802506 no 2488 0.227715461223015 3730 17190742
SGTC_653 0203-0016 55.2 µM -0.748511036857325 0.268066669516823 no 2489 0.227075985201031 3781 295302
SGTC_3066 9117245 49.47 µM -0.7531453383426 0.266785500167485 no 2490 0.225681291145688 3829 17176980
SGTC_868 0527-0199 213 µM -0.754261118987916 0.266477501427175 no 2491 0.22534622206044 3725 2849450
SGTC_154 3389-1638 511.116 µM -0.755794494603644 0.266054523910331 no 2492 0.22488620903785 3685 5238686
SGTC_2447 5741742 33.78 µM -0.755847883950388 0.266039802731706 no 2493 0.22487020181804 3813 1776504
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.758413000838528 0.265333003047344 no 2494 0.224101888648102 3790 521171
SGTC_2512 diallyl trisulfide 49.23 µM -0.759381213643711 0.265066466901668 no 2495 0.223812274085718 3792 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1849 st056239 19.2 µM -0.760876625954799 0.264655067156474 no 2496 0.223365380420333 3783 5393181
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.762101008959053 0.264318471687531 no 2497 0.222999860361909 3709 756377
SGTC_1644 st010134 20.9 µM -0.76300548271013 0.264069962607445 no 2498 0.222730063041971 3768 3818134
SGTC_3115 9123671 49.47 µM -0.763369912179624 0.263969867285854 no 2499 0.222621409232591 3853 3286988
SGTC_1163 k060-0048 49.9 µM -0.765154275324189 0.263480047893964 no 2500 0.222089841840146 3784 6809982
SGTC_1306 1185-0270 9.02 µM -0.766042141304374 0.263236495818227 no 2501 0.221825613949401 3801 1548076
SGTC_2837 9008476 45.46 µM -0.766193472823205 0.26319499527676 no 2502 0.221780595781544 3768 2992805
SGTC_460 trequinsin 123 µM -0.766469478483809 0.263119313212558 no 2503 0.221698502935535 3823 5537 A vasodilator.
SGTC_1482 3346-2049 8.48 µM -0.766509518920859 0.263108334858029 no 2504 0.221686595080603 3797 3826804
SGTC_1188 1403-0014 4.57 µM -0.767030027852036 0.26296564214272 no 2505 0.221531831205925 3807 9614867
SGTC_1863 st057641 20.1 µM -0.768986513063904 0.262429643829328 no 2506 0.220950658521047 3807 3921635
SGTC_545 4218-0007 221 µM -0.769321673650666 0.262337879451349 no 2507 0.220851186915142 3737 2840508
SGTC_2144 5628481 200 µM -0.770628683896465 0.26198018721139 no 2508 0.220463527133851 3779 2818399
SGTC_2974 9094440 9.66 µM -0.770977447234253 0.261884782695838 no 2509 0.220360149734965 3867 25236134
SGTC_2729 fluphenazine 10.66 µM -0.772810583545806 0.261383619764345 no 2510 0.219817244471987 3720 3372 An atypical antipsychotic.
SGTC_126 0417-1624 672.48 µM -0.77382991867778 0.261105155987866 no 2511 0.219515688631977 3863 41912 YDL195W SEC31
SGTC_3355 9151058 44.0485 µM -0.774878580147979 0.26081884000458 no 2512 0.219205705142507 3802 17015728
SGTC_2751 anetholtrithion 17.25 µM -0.775982935094055 0.260517492740761 no 2513 0.218879530907797 3803 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1341 1486-1360 280 µM -0.77717895765475 0.260191334306717 no 2514 0.218526597547603 3762 3976547
SGTC_673 1082-0474 110 µM -0.777427796399889 0.260123501797557 no 2515 0.218453209119157 3806 3098046
SGTC_2802 7925815 54.55 µM -0.777534162581537 0.260094509556558 no 2516 0.218421843548526 3803 1262923
SGTC_2766 oltipraz 83.91 µM -0.779513705753968 0.25955524943118 no 2517 0.217838583569256 3759 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2103 5378138 10 µM -0.780114770982943 0.259391623710373 no 2518 0.21766166142012 3831 244142
SGTC_235 0330-0087 5 mM -0.780301797067466 0.259340721176922 no 2519 0.217606627645567 3840 46494818 YHR062C RPP1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.780618849924182 0.259254441296567 no 2520 0.21751335090241 3809 5106787 A p450 inhibitor.
SGTC_2427 5545055 42.75 µM -0.781122105933222 0.259117520251975 no 2521 0.217365340713417 3780 5372858
SGTC_3119 9125183 49.47 µM -0.781685299967982 0.258964336190082 no 2522 0.21719977141955 3655 22695334
SGTC_2511 berberine 10.47 µM -0.783229953630647 0.258544443864853 no 2523 0.216746044074067 3794 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1035 k081-0041 55.2 µM -0.783788637275113 0.258392660462991 no 2524 0.216582071130575 3788 731709
SGTC_2883 9059145 45.46 µM -0.783818022325166 0.258384678398708 no 2525 0.216573448642521 3798 16476510
SGTC_380 3970-0968 6 µM -0.784000664046595 0.258335069030234 no 2526 0.216519860331597 3745 2891601
SGTC_1358 1509-0022 2.48 µM -0.784649004346659 0.258159005908965 no 2527 0.216329694887778 3842 3258434
SGTC_1911 st060208 74.3 µM -0.785066604146814 0.258045635566152 no 2528 0.216207259415342 3862 688783
SGTC_1952 st077036 64.1 µM -0.785285616944577 0.2579861881124 no 2529 0.216143063417546 3800 2937007
SGTC_931 2812-0076 566 µM -0.786551295318662 0.25764277955476 no 2530 0.215772290032889 3827 3450959
SGTC_793 0488-0545 106 µM -0.786636745980869 0.257619603319808 no 2531 0.215747271032564 3811 292548
SGTC_619 1652-1634 108 µM -0.787082291668583 0.257498778361557 no 2532 0.215616847472579 3774 5400454
SGTC_2942 9052777 62.25 µM -0.787131861276088 0.25748533768626 no 2533 0.215602339902525 3894 6469503
SGTC_2008 4012253 172 µM -0.78736406510427 0.257422381050605 no 2534 0.215534388189941 3825 603940
SGTC_1949 st076024 69.1 µM -0.787417827680611 0.257407805726122 no 2535 0.215518656976852 3768 2921930
SGTC_540 1187-0821 17.3 µM -0.787762178322892 0.257314460579052 no 2536 0.215417913958095 3770 847520
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.788165890165816 0.257205046451112 no 2537 0.2152998390582 3817 688761
SGTC_1729 st035615 45.989 µM -0.788969684104892 0.25698727397307 no 2538 0.215064862719942 3884 17385451
SGTC_2485 5633444 17.78 µM -0.789023515039486 0.25697269294654 no 2539 0.215049131426459 3845 5724239
SGTC_1436 4092-1007 8.32 µM -0.789261325540109 0.256908283068389 no 2540 0.214979642825314 3805 2881121
SGTC_2160 5660466 132.927 µM -0.79191534921128 0.256190023415071 no 2541 0.214205018220549 3749 2859134
SGTC_3205 9113483 49.47 µM -0.791972767554403 0.256174495841741 no 2542 0.214188277609114 3890 17018033
SGTC_2841 9004761 38.96 µM -0.792203529435286 0.256112096134082 no 2543 0.214121005480885 3813 2991039
SGTC_3243 9134147 49.47 µM -0.793724583998707 0.255700990221453 no 2544 0.213677892577543 3860 24282180
SGTC_63 0099-0242 26.702 µM -0.795043158019599 0.255344889138529 no 2545 0.213294198824128 3870 3898502 YLR359W ADE13
SGTC_2001 4023502 57.655 µM -0.795108939021875 0.255327130763437 no 2546 0.213275067641872 3850 108941 YCR052W RSC6
SGTC_1259 0671-0132 43 µM -0.797246348999033 0.254750462618197 no 2547 0.21265398629875 3782 X1259
SGTC_210 3551-0445 56.827 µM -0.800467361178333 0.253882731000058 no 2548 0.21172003331024 3844 2865180 YOR207C RET1
SGTC_970 1315-0089 19.5 µM -0.801693782794789 0.253552744726709 no 2549 0.211365056538264 3785 6811083 YLR033W RSC58
SGTC_1839 st053978 48 µM -0.801915764927592 0.253493041351775 no 2550 0.211300843073892 3851 3788398
SGTC_2641 levomentholum 100 µM -0.802364552705949 0.253372359857534 no 2551 0.21117105574638 3799 16666
SGTC_2673 kobusone 100 µM -0.802919853235584 0.253223078311306 no 2552 0.211010530107878 3869 6710676 An epoxy ketone and protein crosslinker.
SGTC_1970 st070122 35.8 µM -0.806823485723083 0.252174970793993 no 2553 0.209884093092309 3842 102928
SGTC_2417 cerulenin 830 nM -0.807869928497128 0.251894395064601 no 2554 0.209582732070098 3879 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2153 5569715 200 µM -0.808488615007575 0.251728588313155 no 2555 0.209404678707924 3850 2054701
SGTC_651 3253-0966 34.4 µM -0.810836066217749 0.251100000637201 no 2556 0.208729909807888 3872 781462
SGTC_2472 5377652 49.4 µM -0.811700499999069 0.250868736633977 no 2557 0.208481753692142 3917 1610903
SGTC_786 4544-0069 423 µM -0.812556366326063 0.250639875827252 no 2558 0.208236228547459 3889 748821 YLR208W SEC13
SGTC_2206 7254556 146.969 µM -0.814393604901241 0.250148967359078 no 2559 0.207709750522852 3863 4398905
SGTC_1891 st059073 26.2 µM -0.814457709423607 0.250131847901779 no 2560 0.207691394976095 3896 688754
SGTC_2245 6637752 200 µM -0.814594060544708 0.250095436668755 no 2561 0.207652355685531 3923 681890
SGTC_6 0844-0013 19.835 µM -0.81613762674092 0.249683438577456 no 2562 0.207210712875117 3962 1584900
SGTC_1348 1493-0373 93.8 µM -0.817361195086491 0.249357108412398 no 2563 0.206861022406456 3863 3010129
SGTC_1122 capsaicin 818.572 nM -0.817919489611354 0.24920828457633 no 2564 0.206701580402707 3966 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2294 7971431 200 µM -0.82142238746438 0.248275600669112 no 2565 0.205702857926755 3827 5741572
SGTC_229 benomyl 22.8748 µM -0.824768109847348 0.247386507139299 no 2566 0.204751627502046 3890 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2314 7727897 200 µM -0.830042318391898 0.245988400012029 no 2567 0.203257428862289 3887 900724
SGTC_3142 9086498 49.47 µM -0.830967624744478 0.24574355417457 no 2568 0.202995959510129 3828 25236367
SGTC_2104 5389443 200 µM -0.831447948173938 0.245616507129509 no 2569 0.202860310877345 3930 2244536
SGTC_2281 7943571 200 µM -0.832062872781608 0.245453909157647 no 2570 0.202686728444876 3985 1244024
SGTC_1975 st070967 30.8 µM -0.832078309315363 0.245449828183565 no 2571 0.202682372124484 3834 261391
SGTC_3285 9112818 20.8695 µM -0.834259854216346 0.244873457494295 no 2572 0.202067284570599 3871 17017947 YPR165W RHO1
SGTC_1573 oleylamine 1.06 µM -0.834392953306635 0.244838315907659 no 2573 0.202029793413924 3887 5356789 An amine of the fatty acid oleic acid.
SGTC_291 SEC14.278 35.5 µM -0.835001241180852 0.244677746803019 no 2574 0.201858504773828 3879 1068044
SGTC_1680 diphenhydramine 100 µM -0.836914326213754 0.244173121584196 no 2575 0.201320363492016 3909 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1969 st069479 40.1 µM -0.839381106590775 0.243523274208929 no 2576 0.200627741293557 3891 3895485
SGTC_641 4092-0595 30 µM -0.840197445258811 0.243308424278636 no 2577 0.20039884529449 3920 786260
SGTC_1702 st027038 51 µM -0.841560810873891 0.242949832369774 no 2578 0.200016916484968 3929 5521182
SGTC_695 3505-6186 243 µM -0.844130340039952 0.242274773717853 no 2579 0.199298287641476 3894 1819379
SGTC_684 1140-0066 328 µM -0.844807243116137 0.24209710918876 no 2580 0.199109234946165 3950 6813534
SGTC_644 1498-1197 63.3 µM -0.845337943327833 0.241957867465572 no 2581 0.198961090926231 3957 6741615
SGTC_635 k038-0028 24.7 µM -0.845814112105737 0.241832970334545 no 2582 0.198828225813765 3894 4035102
SGTC_2182 6325192 200 µM -0.84637180545216 0.241686734132403 no 2583 0.1986726809709 3820 736248
SGTC_2378 9074213 121.43 µM -0.847721972351103 0.241332897432232 no 2584 0.198296413322136 3867 657714
SGTC_758 0868-0029 16 µM -0.847786012084907 0.241316121606783 no 2585 0.198278577270488 3965 762687
SGTC_1660 st012960 28.1 µM -0.84881283018972 0.241047223260121 no 2586 0.197992724873933 3905 24207266
SGTC_428 3448-4153 16.5 µM -0.848877656698207 0.241030252265295 no 2587 0.197974686399515 3869 3834874
SGTC_891 0929-0073 133 µM -0.849702304559033 0.240814423611617 no 2588 0.1977453084258 3966 5603632
SGTC_543 3844-1095 191 µM -0.850352765904547 0.240644257646424 no 2589 0.197564494235684 3910 4230703
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.850353251389941 0.240644130663956 no 2590 0.197564359318579 3910 364106
SGTC_996 3970-0799 1.8 µM -0.850693501143973 0.240555144674226 no 2591 0.197469817110861 3937 6615648 YGL040C HEM2
SGTC_2407 paclitaxel 400 µM -0.854957496006211 0.239441496761208 no 2592 0.196287339299949 4083 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3302 9125395 16.351 µM -0.855302416171678 0.239351535560493 no 2593 0.196191875145555 3864 17599668
SGTC_1199 1638-0010 4.46 µM -0.855596734440807 0.239274786817996 no 2594 0.19611043843119 3891 3111136
SGTC_1905 st060207 84.5 µM -0.858917397666248 0.238409796890782 no 2595 0.195193045098061 3843 1948547
SGTC_932 2857-0803 154 µM -0.859333497983412 0.2383015289787 no 2596 0.195078274013493 4007 674898
SGTC_3126 9127922 49.47 µM -0.859349957751679 0.238297246755793 no 2597 0.195073734833031 3947 45595682
SGTC_746 1095-0025 46.6 µM -0.860486141460038 0.238001755673952 no 2598 0.194760559805364 3935 6749286
SGTC_2567 aureobasidin a 60 nM -0.861571999113673 0.237719540868744 no 2599 0.194461542532036 4090 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_448 monastrol 171 µM -0.862782488981859 0.237405150618215 no 2600 0.194128534350967 3833 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_857 0438-0306 1.35 µM -0.863227626858056 0.237289596173382 no 2601 0.194006163442242 3997 4686136
SGTC_116 0155-0182 31.788 µM -0.863994058670997 0.23709070863891 no 2602 0.193795577182943 3855 771486
SGTC_2817 7995342 71.43 µM -0.864577083615971 0.236939476186363 no 2603 0.193635477496472 3925 18879975
SGTC_3072 9116419 49.47 µM -0.865174655501494 0.236784525407721 no 2604 0.193471466920195 3959 17170162
SGTC_3280 9140961 49.47 µM -0.865693264949544 0.236650094820039 no 2605 0.193329197215422 3965 4901226
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.865770506376721 0.236630076389712 no 2606 0.193308013101608 3959 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1277 0873-0036 22 µM -0.866577051440716 0.236421102172544 no 2607 0.193086895935504 3993 5965735
SGTC_336 4111-0029 111 µM -0.866963938432283 0.236320896588229 no 2608 0.19298088433162 3925 3131175
SGTC_2905 7799065 20.05 µM -0.869196724602439 0.23574305142492 no 2609 0.192369769322222 3827 1296806
SGTC_1082 camptothecin 424.86 nM -0.869634009162957 0.235629973467267 no 2610 0.192250222982516 3848 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2799 7812892 81.82 µM -0.870241177521492 0.235473014669965 no 2611 0.192084308603011 3962 20205235
SGTC_555 4296-0685 37 µM -0.871140128902361 0.235240733168206 no 2612 0.191838822754136 3872 2908540 YHR072W ERG7
SGTC_2108 5365811 200 µM -0.871753063516897 0.235082428569347 no 2613 0.191671552608573 3975 780283
SGTC_2484 5809818 12.04 µM -0.87191642684479 0.235040246130128 no 2614 0.191626985759835 3916 2870548
SGTC_914 3820-6779 408 µM -0.873490485086015 0.234634019071701 no 2615 0.191197895105744 3893 2893481
SGTC_826 1683-5028 118 µM -0.875819213533022 0.234033742331027 no 2616 0.19056416160028 4000 722377
SGTC_3168 9103419 49.47 µM -0.875839549535524 0.23402850406526 no 2617 0.19055863310459 3910 16649256
SGTC_152 4469-0003 551.229 µM -0.877793916136803 0.233525390079144 no 2618 0.190027783330806 3862 697280
SGTC_3247 9135149 49.47 µM -0.879612478818832 0.233057775482901 no 2619 0.189534638200007 3920 8934436 YOR116C RPO31
SGTC_410 α-linolenic acid 100 µM -0.879840837965984 0.232999093310637 no 2620 0.189472769056502 4017 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2020 4017018 200 µM -0.880419258614572 0.232850491449921 no 2621 0.189316113673131 4041 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2891 9063876 19.48 µM -0.881200292227079 0.232649919936927 no 2622 0.189104710577342 3933 6472478
SGTC_3199 9111318 49.47 µM -0.882297569658229 0.232368298474693 no 2623 0.188807955187809 3907 8548020
SGTC_1883 5-benzylidenerhodanine 20 µM -0.883251594582861 0.232123597639756 no 2624 0.188550175376869 3948 1273210
SGTC_2023 5144124 124 µM -0.883597163055827 0.232034997101523 no 2625 0.188456855515849 3947 2830192
SGTC_225 nsc-122657 1.016 µM -0.8858688283764 0.231453032209916 no 2626 0.187844107584657 3948 275685
SGTC_1265 0819-1001 68.8 µM -0.8861849608852 0.231372108596985 no 2627 0.187758933169749 3910 3106768
SGTC_51 1013-0126 23.419 µM -0.8863262996801 0.231335933791244 no 2628 0.187720860497747 3945 1627850
SGTC_1372 2752-0194 270 µM -0.887345744299849 0.231075106588091 no 2629 0.187446392228333 3912 823334
SGTC_258 haloperidol 50.781 µM -0.889816935906171 0.230443528302036 no 2630 0.186782095613205 3993 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1520 flindersine 88 µM -0.890812701266819 0.230189307185582 no 2631 0.186514830027164 4096 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2977 9011197 71.43 µM -0.891628889523505 0.229981049548988 no 2632 0.186295940044113 4063 2704722
SGTC_2769 toremifene 3.73 µM -0.892526626647221 0.229752105830614 no 2633 0.186055363722 3953 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1108 betulinic acid 729.144 nM -0.893944244243029 0.229390840607145 no 2634 0.185675861796551 3964 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1373 2887-0003 58.5 µM -0.894985132980912 0.229125783698213 no 2635 0.185397517701288 3951 776948
SGTC_1569 carminic acid 40.6 µM -0.895748818289593 0.228931424504224 no 2636 0.185193465417083 4045 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1141 3253-0389 52.6 µM -0.89707084959563 0.228595184125392 no 2637 0.184840556196547 3925 5402031
SGTC_956 1185-0240 191 µM -0.89751766483365 0.228481605593228 no 2638 0.184721375816453 3964 1416193
SGTC_804 1595-0054 20.9 µM -0.898537825821195 0.228222403875372 no 2639 0.184449444297113 3906 761523 Stimulates phospholipase C.
SGTC_244 nsc-207895 1.295 µM -0.90002521010399 0.227844786800527 no 2640 0.184053417386039 3776 42640
SGTC_782 0083-0095 30.5 µM -0.900418090962705 0.227745100951088 no 2641 0.183948898439355 3939 3591729 An indicator and reagent.
SGTC_45 0kpi-0036 14.9 µM -0.900439356723659 0.22773970587974 no 2642 0.183943242117479 4006 2795021
SGTC_1900 st060200 72.8 µM -0.900942531464062 0.22761207267292 no 2643 0.183809438005083 3950 688945
SGTC_560 2332-1943 155 µM -0.90119369805377 0.227548377875041 no 2644 0.1837426705331 3944 21177716
SGTC_1185 1319-0113 81.3 µM -0.903750318587171 0.226900600951901 no 2645 0.183063905435264 4044 4672763
SGTC_1960 st011366 51.8 µM -0.903766801999342 0.226896427888663 no 2646 0.183059534284743 3980 3972846
SGTC_3250 9135583 49.47 µM -0.904999023184195 0.226584592211457 no 2647 0.182732952342094 3996 7699353
SGTC_3035 9091303 49.47 µM -0.907710342250431 0.22589929679794 no 2648 0.182015639158499 4029 25237002
SGTC_117 lucigenin 22.078 µM -0.908442296559972 0.225714493880873 no 2649 0.181822293752973 4015 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_24 0417-1663 219 µM -0.909139464584518 0.225538553316274 no 2650 0.181638256632146 3983 4329390
SGTC_897 1000-0139 31.4 µM -0.909974222634124 0.225327992037285 no 2651 0.181418052154658 3931 6151020
SGTC_1340 1486-1359 257 µM -0.910729964730208 0.225137457969589 no 2652 0.181218835854339 3913 4309068
SGTC_2670 beta-carotene 100 µM -0.910840582928348 0.225109577100537 no 2653 0.181189688003719 3913 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_349 k015-0014 24 µM -0.911323454467657 0.224987894194043 no 2654 0.181062485937217 3971 2196908
SGTC_2092 5303694 80.6725 µM -0.912707979581727 0.224639202690662 no 2655 0.180698073024175 3981 1963699
SGTC_511 blebbistatin 171 µM -0.914183017123725 0.224268053192965 no 2656 0.180310343174575 4067 3476986 A myosin inhibitor.
SGTC_1186 1319-0216 26 µM -0.914291284691163 0.224240824589234 no 2657 0.180281904433948 4047 4565136
SGTC_3264 9137442 49.47 µM -0.916643593909206 0.223649697414683 no 2658 0.179664716306664 3984 17015726
SGTC_3079 9117512 49.47 µM -0.917158909570086 0.223520318789893 no 2659 0.17952968763225 4012 7185044
SGTC_1701 st028638 40.4 µM -0.918894229072011 0.22308495097445 no 2660 0.179075449363016 3974 3490878
SGTC_2980 9014342 25.29 µM -0.919715186039118 0.222879152526502 no 2661 0.17886080735043 4058 2996599
SGTC_2399 5884133 200 µM -0.921234958414446 0.222498459811332 no 2662 0.17846388521765 4009 722445
SGTC_2464 5717415 7.67 µM -0.922078926412399 0.222287211762259 no 2663 0.178243704141915 3991 5285744
SGTC_2299 7976368 114.88 µM -0.922655768368676 0.222142892125655 no 2664 0.178093311569311 4042 2979718
SGTC_1494 4358-1428 177 µM -0.923208205747055 0.222004728397548 no 2665 0.177949356702833 4026 1564571
SGTC_3349 9149703 23.001 µM -0.928633233637736 0.220650546543944 no 2666 0.176539596328291 4008 4910494
SGTC_3289 9119912 71.43 µM -0.933085581146858 0.219542706700332 no 2667 0.175387891590313 4058 17014829
SGTC_2134 5324836 1.464 µM -0.93344165479601 0.219454246100085 no 2668 0.175295990897795 3976 699272
SGTC_3340 9146634 11.102 µM -0.933620782778515 0.21940975246289 no 2669 0.175249770475805 4035 4907387
SGTC_869 0564-0080 44.1 µM -0.933767911634134 0.21937321097286 no 2670 0.175211812575027 4038 6843321
SGTC_2363 9053361 176 µM -0.934959742533972 0.219077332183132 no 2671 0.174904523304381 4089 6469797 YMR079W SEC14
SGTC_2566 crystal violet carbinol 226 nM -0.935514732357536 0.218939631154254 no 2672 0.174761547288127 4075 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2106 5357045 167.29 µM -0.937088509997181 0.218549424958029 no 2673 0.174356515627158 4045 668842
SGTC_2844 9010103 25.97 µM -0.937388518751826 0.218475085536508 no 2674 0.174279372298224 4066 2480525
SGTC_1264 0783-0040 158 µM -0.937448754612683 0.218460161397482 no 2675 0.174263886048945 3911 2855798
SGTC_2774 tamoxifen 10.92 µM -0.939068974116119 0.218058953404176 no 2676 0.173847666234664 4023 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2678 equilin 100 µM -0.94206617725586 0.217317889577954 no 2677 0.173079379829163 4031 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2087 5276107 200 µM -0.943425636062475 0.216982240983844 no 2678 0.172731617773023 3982 144405
SGTC_132 0417-1715 25.805 µM -0.944008327668262 0.216838466974655 no 2679 0.172582696371138 3970 6769098
SGTC_1394 3474-0001 65.7 µM -0.947028136904076 0.216094238630397 no 2680 0.171812220757545 4008 5017666 YIL048W NEO1
SGTC_3124 9127567 49.47 µM -0.948134459562989 0.215821957464645 no 2681 0.171530503713373 4039 17592030
SGTC_1614 st002383 48.6 µM -0.949678926010885 0.215442175852578 no 2682 0.171137710503596 4032 1947235
SGTC_1847 st056231 15 µM -0.950361006747741 0.215274576872937 no 2683 0.170964425002438 4021 5393180
SGTC_2172 5754775 163.918 µM -0.955056288468177 0.214122920203713 no 2684 0.169774616212406 4003 2263357
SGTC_3080 9117754 49.47 µM -0.955207637628746 0.214085857091287 no 2685 0.169736352100825 4053 9550191
SGTC_3207 9114163 49.47 µM -0.956330008856523 0.213811121939266 no 2686 0.169452766694573 4093 849233
SGTC_640 3381-0960 37.1 µM -0.95717960674037 0.213603293119932 no 2687 0.169238304227828 4085 1745025
SGTC_674 0498-0004 451 µM -0.957227949907261 0.213591470944195 no 2688 0.169226106291107 4033 4231473
SGTC_1113 artemisinin 1.17947 µM -0.957374423978761 0.213555653479108 no 2689 0.169189151433175 4079 2240 An anti-malaria and mitochondrial poison.
SGTC_3089 9117425 49.47 µM -0.957580557084449 0.213505253453974 no 2690 0.169137153602576 4032 9401657
SGTC_958 1222-0007 33 µM -0.958166054767267 0.213362135717504 no 2691 0.168989515643276 4121 7312461
SGTC_1673 st016611 27.3 µM -0.958447516439331 0.213293355769377 no 2692 0.168918572284063 4068 5226799
SGTC_1015 4130-4525 82 µM -0.958650852106751 0.213243675283869 no 2693 0.168867332751993 4034 1363237
SGTC_2105 5350118 200 µM -0.959630742118985 0.213004355885777 no 2694 0.168620545592621 4034 2133313
SGTC_3284 9108171 64.8615 µM -0.961422560319335 0.212567144062008 no 2695 0.168169872660586 4027 8687505
SGTC_1698 5-fluorocytosine 1.055 µM -0.962149033533871 0.212390030724266 no 2696 0.167987373217998 4077 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2089 5281248 129.67 µM -0.962466070357993 0.212312764544056 no 2697 0.167907769445432 4027 2737878
SGTC_714 4296-0578 26.1 µM -0.962802068635241 0.212230895133501 no 2698 0.167823431210231 4075 1589775
SGTC_2835 9006588 71.43 µM -0.963445411878596 0.212074189487558 no 2699 0.167662023069417 4123 2345538
SGTC_2629 bisabolol 100 µM -0.963473581220844 0.212067329541333 no 2700 0.167654957959328 4085 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2616 abietic acid 100 µM -0.963979088856209 0.211944247725021 no 2701 0.167528204949985 4071 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3312 9133330 71.43 µM -0.964338041679662 0.211856874686506 no 2702 0.167438237173624 4095 17617324
SGTC_2497 7-hydroxyflavone 100 µM -0.966357794576206 0.21136563779625 no 2703 0.166932587741052 4087 5281894
SGTC_845 0330-0138 4.51 µM -0.967459852132702 0.211097880969823 no 2704 0.166657101042961 4019 9039800
SGTC_1524 corynanthine 62.1 µM -0.968457777798338 0.210855595712714 no 2705 0.166407897969375 4186 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_688 0527-0193 473 µM -0.969033305906905 0.210715938062287 no 2706 0.166264285918551 4081 4007154
SGTC_2804 7954240 19.48 µM -0.969341953221577 0.210641064063688 no 2707 0.16618730185878 4096 828705
SGTC_1039 k821-0043 94 µM -0.970826256299303 0.21028120870588 no 2708 0.16581740266866 4074 15992768
SGTC_2247 cerulenin 830 nM -0.97194413197636 0.210010428715748 no 2709 0.165539171499332 4110 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1953 st076800 12.1 µM -0.973151897865821 0.209718105247051 no 2710 0.165238906864346 4075 297591
SGTC_3077 9117319 49.47 µM -0.974941245748963 0.209285457777505 no 2711 0.164794702552103 4036 17154678
SGTC_1705 st027868 56.3335 µM -0.975440330564333 0.209164877532813 no 2712 0.164670943198703 4007 292948
SGTC_1904 st060225 78 µM -0.975777076810173 0.209083541841109 no 2713 0.164587473392657 4000 66595
SGTC_1605 st000082 49.1 µM -0.975901852390297 0.209053409016953 no 2714 0.164556552042122 4036 1114022
SGTC_1997 st073024 93.8 µM -0.975976294807941 0.209035432676651 no 2715 0.164538105833804 4064 686268
SGTC_2453 5731132 22.18 µM -0.976177456650815 0.208986860708565 no 2716 0.164488266315702 4109 1362040
SGTC_1100 amiodarone 5.07 µM -0.977037368589193 0.208779303768586 no 2717 0.164275326316327 4159 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2848 9016370 25.97 µM -0.977281672054247 0.208720358407588 no 2718 0.164214862067351 4046 7894410
SGTC_2705 st078069 42.8 µM -0.979040536548291 0.208296270460634 no 2719 0.163779975342636 4122 1530061
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.979514374104098 0.208182108277649 no 2720 0.163662944928272 4133 688664
SGTC_1007 4101-0031 70 µM -0.979987285452051 0.208068206069248 no 2721 0.163546197418345 4034 1146276
SGTC_3045 9092950 49.47 µM -0.980361892426993 0.207978006897957 no 2722 0.163453756680828 4011 44120432
SGTC_3038 9091290 49.47 µM -0.985953342545557 0.206634424071737 no 2723 0.162078004476295 4102 25236843
SGTC_1545 lovastatin 49.4 µM -0.988318300535635 0.206067693096927 no 2724 0.161498392754987 4141 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1519 esterone 74 µM -0.991244484682942 0.205367748961199 no 2725 0.160783106820309 4037 698 A steroid.
SGTC_2655 perillic acid 100 µM -0.992128199888095 0.205156641961464 no 2726 0.160567495916905 4104 5702197 An apoptosis inducer.
SGTC_2873 9040596 71.43 µM -0.992514577149894 0.205064382456755 no 2727 0.160473286056438 4078 6463863
SGTC_1654 st012436 41.8 µM -0.995760833257716 0.204290212983712 no 2728 0.159683182344575 4024 4323132
SGTC_876 0720-0963 56.8 µM -0.99854974256854 0.203626503690182 no 2729 0.159006428234851 4117 765861
SGTC_2109 5483026 200 µM -1.00081122423861 0.203089257770069 no 2730 0.158459041033308 4101 759335
SGTC_936 3005-4620 401 µM -1.00115667181884 0.203007266544782 no 2731 0.158375535078454 4144 777207
SGTC_2514 salinomycin 42.74 µM -1.00300268014737 0.202569455676561 no 2732 0.157929784053741 4143 23682228 A polyether potassium ionophore.
SGTC_402 epigallocatechin gallate 10 µM -1.00392852616141 0.202350088934971 no 2733 0.157706532810635 4043 65064 An antioxidant.
SGTC_1353 1498-1206 8.11 µM -1.00616269972572 0.201821317006805 no 2734 0.157168655871873 4133 6756808
SGTC_326 k292-0812 17.5 µM -1.00640953235484 0.201762948811888 no 2735 0.157109305043096 4077 3579357
SGTC_1033 k072-0102 21.3 µM -1.00698922524126 0.201625909333981 no 2736 0.156969976034516 4081 5965931
SGTC_1731 st035964 63 µM -1.00816420805706 0.201348314335316 no 2737 0.156687818697135 4040 6739575
SGTC_2654 protoveratrine a 100 µM -1.00819805171509 0.201340322014002 no 2738 0.15667969651789 4085 5702278 A heart drug and vasodilator.
SGTC_1635 st007035 42.4 µM -1.0086747264829 0.201227773477645 no 2739 0.156565328220322 4069 3716403
SGTC_2457 5731572 11.68 µM -1.00901690925631 0.201147003351501 no 2740 0.156483262405572 4157 2865357
SGTC_1661 st013063 9.66 µM -1.01025890941382 0.200854000290864 no 2741 0.156185631096284 4148 721395
SGTC_2175 5807670 165.306 µM -1.01051296379414 0.200794097317041 no 2742 0.156124795813094 4078 241186
SGTC_2557 derrustone 83.84 µM -1.01174106660249 0.200504676639856 no 2743 0.155830937308933 4099 629853 An antioxidant.
SGTC_112 phenothiazine 287.218 µM -1.0119615967653 0.200452731975597 no 2744 0.155778207845039 4035 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3150 9097574 49.47 µM -1.01248721704992 0.200328957609976 no 2745 0.155652577804488 4135 17217476
SGTC_2162 5663267 200 µM -1.01405388325067 0.199960307664953 no 2746 0.15527852085123 4090 6456493
SGTC_875 0709-0210 25.7 µM -1.01420179758296 0.19992552324559 no 2747 0.155243235528219 4113 6251364
SGTC_245 methotrexate 289.6 µM -1.0162279394617 0.199449409990195 no 2748 0.15476042728215 4083 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2568 diosmetin 100 µM -1.01640530451957 0.199407764350408 no 2749 0.15471821033164 4163 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1951 sophoraflavanone G 9.2 µM -1.01644045230397 0.199399512207941 no 2750 0.154709845256506 4075 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1068 loratadine 26.9 µM -1.01968613490616 0.198638363795588 no 2751 0.153938669728847 4144 3957 A H1 histamine antagonist.
SGTC_629 3448-6466 76.7 µM -1.02011685146262 0.198537487864526 no 2752 0.153836522808614 4112 573744
SGTC_470 aa-861 153 µM -1.02093143078985 0.198346793893652 no 2753 0.153643463290823 4091 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_823 0417-1665 178 µM -1.02209262979958 0.198075147019642 no 2754 0.153368530564943 4103 3429856
SGTC_190 3970-0790 3.722 µM -1.02214786965102 0.198062230000261 no 2755 0.153355459758814 4015 2832352
SGTC_3143 9086658 49.47 µM -1.02279724756334 0.197910420753609 no 2756 0.153201859846831 4170 25236626
SGTC_162 k030-0015 37.8 µM -1.02280651184644 0.197908255491279 no 2757 0.153199669267368 4199 1809920 YMR134W ERG29
SGTC_1267 0828-0272 9.49 µM -1.02391098165831 0.197650219684318 no 2758 0.152938661387622 4200 745334
SGTC_2822 7994718 71.43 µM -1.02405830842591 0.197615815306172 no 2759 0.152903867482934 4086 1018011
SGTC_596 1155-0152 116 µM -1.02422423352628 0.197577072100169 no 2760 0.152864687527333 4104 280313
SGTC_1290 0986-0249 10.2 µM -1.02424562091101 0.197572078519236 no 2761 0.152859637800631 3981 53329
SGTC_2560 caryophyllene 100 µM -1.0254504138217 0.197290903625845 no 2762 0.152575355513493 4153 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_409 arachidonic acid 100 µM -1.02573367278771 0.197224831733468 no 2763 0.15250856884409 4113 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1602 st001878 87.6 µM -1.02962586395656 0.196318310600823 no 2764 0.151592834587609 4131 595405 YLR310C CDC25
SGTC_965 1291-5240 308 µM -1.02997943895682 0.196236085614371 no 2765 0.151509828799281 4142 2834598
SGTC_174 3553-0389 74.3 µM -1.03259069404312 0.195629476757753 no 2766 0.150897742489655 4210 738071
SGTC_1940 st075990 51.1 µM -1.03296817027598 0.195541881240658 no 2767 0.150809397242927 4222 1084979
SGTC_3232 9132874 49.47 µM -1.03303060795288 0.195527394516884 no 2768 0.150794787531301 4082 3784940
SGTC_2070 5230947 200 µM -1.0336145336886 0.195391944237053 no 2769 0.150658201113744 4206 2835538
SGTC_1640 st009078 66.4 µM -1.0343295535816 0.19522616236487 no 2770 0.150491062625542 4091 690618
SGTC_170 4197-0004 226 µM -1.03445372002973 0.195197382303503 no 2771 0.150462050860848 4153 218692
SGTC_2044 5102272 200 µM -1.03838243833277 0.194288091811845 no 2772 0.149546021133858 4129 592666
SGTC_2395 5646831 180.19 µM -1.04092360369561 0.193701322511505 no 2773 0.148955502999367 4169 6808628
SGTC_499 genistein 192 µM -1.04384446564204 0.19302821548051 no 2774 0.148278677625494 4204 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2191 5911152 200 µM -1.04503159080232 0.192755053471033 no 2775 0.148004184585254 4144 2875902
SGTC_573 3702-0553 84.7 µM -1.04898342005819 0.191847425636387 no 2776 0.147092874676505 4095 1222756
SGTC_396 dithiazanine 1.25 µM -1.05130061504014 0.191316447829671 no 2777 0.146560272353536 4137 10578 An antihelmenthic.
SGTC_2149 5554786 194.827 µM -1.05317058879521 0.190888606761647 no 2778 0.146131407742782 4167 745063 YPR165W RHO1
SGTC_2552 juarezic acid 87.02 µM -1.05567838611287 0.190315756976055 no 2779 0.145557587557959 4116 1549512
SGTC_3348 9149464 3.537 µM -1.05778855639864 0.189834555137831 no 2780 0.145075925568591 4097 1951442
SGTC_3345 9148410 3.559 µM -1.05954117371558 0.189435458705591 no 2781 0.144676694090889 4115 4903596
SGTC_2712 st079126 47.7 µM -1.06111356744338 0.189077841598647 no 2782 0.144319146377302 4151 3152970
SGTC_798 1287-0182 476 µM -1.06156476151979 0.188975301172957 no 2783 0.144216659103954 4189 1649755
SGTC_2260 7964312 200 µM -1.0618175428246 0.188917867915235 no 2784 0.144159262099035 4211 231951
SGTC_2854 9024559 71.43 µM -1.06389373635885 0.188446552701326 no 2785 0.143688420420126 4206 3163529
SGTC_1398 3558-0053 112 µM -1.06392205758547 0.18844012853756 no 2786 0.14368200488097 4072 4532369
SGTC_2556 citropten 84.59 µM -1.0642224389645 0.188372000707294 no 2787 0.143613972109447 4186 2775 A potential DNA crosslinker.
SGTC_3177 9107506 49.47 µM -1.0664920972247 0.187857723375258 no 2788 0.143100624614252 4117 8897194
SGTC_873 0591-4978 488 µM -1.06701506119396 0.187739349031541 no 2789 0.142982517443586 4243 3305145
SGTC_2463 5473429 200 µM -1.07191699167385 0.186632024615067 no 2790 0.141878658774097 4141 5399405
SGTC_1386 3228-0095 33.8 µM -1.07237630169711 0.186528476123036 no 2791 0.141775523892034 4179 870181
SGTC_1085 doxorubicin 7.67 µM -1.07602666660325 0.185706790367759 no 2792 0.140957665216129 4190 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2701 st077767 14.721 µM -1.07604917601076 0.185701730546537 no 2793 0.140952631965637 4139 5721188
SGTC_1776 st049249 45.9 µM -1.07700686196275 0.185486534469635 no 2794 0.140738600060579 4186 1822314
SGTC_1124 fisetin 1.16336 µM -1.07855132090985 0.185139814260805 no 2795 0.140393895904744 4189 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2337 9009472 200 µM -1.08032193839291 0.184742818699442 no 2796 0.139999421840455 4154 5742383
SGTC_2761 levamisole 97.89 µM -1.08099697106111 0.18459160699967 no 2797 0.139849230493357 4178 26879 An alkaline phosphatase inhibitor.
SGTC_2988 9073640 71.4286 µM -1.08118990127865 0.184548403524619 no 2798 0.139806324629014 4242 9102229
SGTC_1272 0839-0021 27 µM -1.08263299415663 0.184225446634127 no 2799 0.139485678147534 4188 5027250
SGTC_264 promethazine 12.5 mM -1.0828238553934 0.184182759205507 no 2800 0.139443307421456 4053 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1367 1812-0510 76.9 µM -1.08501320569166 0.18369353637613 no 2801 0.138957903232759 4217 1142582 YDR527W RBA50
SGTC_2677 mitomycin C 100 µM -1.08505056383747 0.183685195516644 no 2802 0.138949630496224 4219 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1396 3511-0007 98.6 µM -1.08618576797897 0.183431853874179 no 2803 0.138698406275656 4198 X1396
SGTC_2772 vinpocetine 57.06 µM -1.08688565365721 0.183275770135464 no 2804 0.13854367366264 4214 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1441 4106-0040 13 µM -1.09337923420474 0.181831567534943 no 2805 0.137113663564408 4179 2904180
SGTC_2028 5153890 36.43 µM -1.09474602656752 0.181528495810654 no 2806 0.136813959092622 4163 2830968 YPR165W RHO1
SGTC_2086 5274770 176.623 µM -1.09702012191157 0.181024940399568 no 2807 0.136316298026486 4217 689278
SGTC_657 3534-0529 86.7 µM -1.09726342116882 0.180971118255894 no 2808 0.136263128063529 4236 1049549
SGTC_1677 st019204 53.9 µM -1.10131875074076 0.180075483876531 no 2809 0.135378976586122 4231 3945625
SGTC_23 0213-0011 39.996 µM -1.10409604455794 0.179463716746008 no 2810 0.1347757384611 4203 627608
SGTC_1901 st060216 58.6 µM -1.10440858240407 0.179394954492651 no 2811 0.134707969760098 4153 688792
SGTC_3192 9110362 49.47 µM -1.10558138165953 0.179137071650034 no 2812 0.134453876028597 4221 16649480
SGTC_3235 9132602 49.47 µM -1.10612799570356 0.179016958257681 no 2813 0.134335561433151 4206 4912240
SGTC_1249 0481-0015 10.2 µM -1.10658205972597 0.178917220419307 no 2814 0.13423733366452 4132 4227577
SGTC_1182 1222-0449 220 µM -1.10852157538678 0.178491588205339 no 2815 0.133818313288212 4195 658318
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.10870222633035 0.178451976339348 no 2816 0.133779330587568 4238 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2917 7979103 53.79 µM -1.10877799030514 0.178435364997237 no 2817 0.133762983789095 4226 2980565
SGTC_459 nigericin 15.3 µM -1.10926748743195 0.178328065645553 no 2818 0.133657403220614 4267 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2664 lyso-paf C-16 73.48 µM -1.11390492675657 0.177313541947425 no 2819 0.132659987800584 4177 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1030 k029-0042 36.7 µM -1.11684244044189 0.176672796997709 no 2820 0.13203084947577 4187 6080581
SGTC_2889 9059656 51.95 µM -1.11743955095274 0.176542731574449 no 2821 0.131903216129023 4282 3949838
SGTC_764 1951-2361 146 µM -1.12197869390755 0.17555597494695 no 2822 0.130935749510055 4218 5438930
SGTC_2306 7482397 179.52 µM -1.12211892626617 0.175525545836367 no 2823 0.130905938867808 4226 891448
SGTC_424 splitomicin 100 mM -1.12431072992569 0.175050379428894 no 2824 0.130440613993158 4273 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2965 9082772 38.63 µM -1.1245240884435 0.175004168546335 no 2825 0.130395378675528 4239 16459634
SGTC_2009 4012297 12.05 µM -1.12711208629764 0.17444425587018 no 2826 0.129847546941571 4207 45595307
SGTC_257 daunorubicin 18.5 µM -1.12761547001902 0.174335481265524 no 2827 0.129741175230269 4243 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1187 1391-0724 117 µM -1.12863084740579 0.174116202721852 no 2828 0.129526796079505 4267 6997986
SGTC_263 alizarin 107.927 µM -1.12879533809353 0.17408069620256 no 2829 0.129492089863609 4250 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1102 cgs 12066b 26.1 µM -1.12893064004489 0.174051493736059 no 2830 0.129463547066882 4228 6438352 A 5-HT1B full agonist.
SGTC_2913 7966556 36.57 µM -1.13199861932792 0.17339016223717 no 2831 0.128817507438476 4100 2976516
SGTC_2340 7987427 183.45 µM -1.13272221906066 0.173234417012503 no 2832 0.128665461941594 4246 2239331
SGTC_2171 5739187 198.077 µM -1.13622058175305 0.172482697937372 no 2833 0.127932129400876 4159 2262761
SGTC_1257 0669-0121 16 µM -1.13841812137806 0.17201156181862 no 2834 0.127472965360163 4237 4307855
SGTC_56 0957-0365 83.25 µM -1.13937309088069 0.171807079794694 no 2835 0.127273787283376 4199 6752360
SGTC_2621 lithochol-11-enic acid 100 µM -1.13947048607617 0.171786233859585 no 2836 0.127253485731249 4186 6708711
SGTC_2200 6600604 21.907 µM -1.13969691290994 0.171737776941693 no 2837 0.127206296872259 4247 2904777
SGTC_3265 9137266 49.47 µM -1.14053310288944 0.171558902132976 no 2838 0.127032134820912 4179 17224265
SGTC_790 1575-0012 79.1 µM -1.14158760788423 0.17133349593656 no 2839 0.126812738703777 4289 378741 YLR208W SEC13
SGTC_2114 5491910 81.25 µM -1.14220530549623 0.171201547672389 no 2840 0.126684345591198 4287 2849228
SGTC_1930 st074634 34.3 µM -1.14242866626135 0.171153850900926 no 2841 0.126637940663018 4136 684253 YOR116C RPO31
SGTC_344 k064-0035 6.43 µM -1.14496607933718 0.170612604857518 no 2842 0.126111604513529 4176 5088750
SGTC_1053 3366-3204 134 µM -1.14614877911728 0.170360702430727 no 2843 0.125866798619688 4252 3632071 YPR165W RHO1
SGTC_3201 9113999 49.47 µM -1.14656116273151 0.170272925166646 no 2844 0.125781517709952 4244 16649224
SGTC_9 0092-0002 10.449 µM -1.14732134401628 0.170111193926316 no 2845 0.125624417906765 4230 759368
SGTC_2478 5763493 32.33 µM -1.14823753405877 0.169916402146116 no 2846 0.125435259183043 4179 1365576 YLR208W SEC13
SGTC_720 r052-1644 49.9 µM -1.15089035619879 0.169353190703788 no 2847 0.124888672866229 4262 1422863 YOR257W CDC31
SGTC_715 0868-0130 184 µM -1.15124487543565 0.169278014824336 no 2848 0.124815754120451 4299 2876258
SGTC_2304 7443016 91.4 µM -1.1523342546316 0.169047145807882 no 2849 0.124591873010937 4178 939854
SGTC_280 3448-3607 3.04 µM -1.15303425992396 0.168898902460135 no 2850 0.124448161359633 4202 626179
SGTC_194 1486-1323 56.904 µM -1.15424563587314 0.16864256117265 no 2851 0.12419973882553 4330 5178754
SGTC_471 1-acyl-paf 4 µM -1.1548627865057 0.168512061101947 no 2852 0.124073310330717 4183 16759367
SGTC_118 0083-0097 135.343 µM -1.15558125002783 0.168360219646865 no 2853 0.123926240508806 4238 5207356
SGTC_1225 1216-0074 20.6 µM -1.15602701239621 0.168266055622876 no 2854 0.123835054098296 4266 4241466
SGTC_1027 k015-0025 8.67 µM -1.15719703533483 0.168019058071098 no 2855 0.123595934357868 4230 3598955
SGTC_2723 salbutamol 83.58 µM -1.15726374095304 0.16800498322395 no 2856 0.123582311357584 4258 9884233 β2-adrenoceptor agonist
SGTC_3019 9081971 49.47 µM -1.15767298799559 0.167918648942269 no 2857 0.123498755617798 4268 16451803
SGTC_1548 st061468 90.8 µM -1.16129762729723 0.167155246131298 no 2858 0.12276044204825 4239 390799
SGTC_3110 9122132 49.47 µM -1.16292062786099 0.166814144531238 no 2859 0.122430853646703 4334 918317
SGTC_3188 9110789 49.47 µM -1.16319442736763 0.166756645134885 no 2860 0.12237531349726 4247 849217
SGTC_3149 9097855 49.47 µM -1.17233137942497 0.164845170992142 no 2861 0.120532018942497 4261 25236625 YMR079W SEC14
SGTC_1133 3473-0247 50 µM -1.17346227331307 0.164609575882448 no 2862 0.12030523865448 4238 711311
SGTC_1363 1636-0063 10.4 µM -1.17420649652882 0.164454653599182 no 2863 0.120156162257657 4265 6072185
SGTC_2328 6201408 200 µM -1.17514981041907 0.164258423184757 no 2864 0.119967392852907 4263 2890418
SGTC_3220 9131269 49.47 µM -1.17635259062557 0.164008438278821 no 2865 0.119727004190091 4293 17722206
SGTC_2816 7982706 58.44 µM -1.18099764804373 0.163045331753844 no 2866 0.118801828818227 4275 2981853
SGTC_2138 5575593 77.673 µM -1.18173569248376 0.162892644716314 no 2867 0.118655295634836 4275 762213
SGTC_180 1486-1293 102.781 µM -1.18215510053744 0.162805918790636 no 2868 0.118572082239985 4186 4140536
SGTC_1071 trifluoperazine 6.31 µM -1.18320258701209 0.162589448895002 no 2869 0.118364433977826 4334 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3233 9132340 49.47 µM -1.18421224861141 0.162380973077137 no 2870 0.118164527356957 4274 17682950
SGTC_2881 9058953 51.95 µM -1.18503114460452 0.162212014550232 no 2871 0.118002566565277 4216 17122249
SGTC_741 4582-0002 126 µM -1.188534503632 0.161490477645088 no 2872 0.117311447270777 4289 2912688
SGTC_1898 st060199 18.6 µM -1.1893192627131 0.161329139328729 no 2873 0.117157029044222 4252 688866
SGTC_1427 4048-4900 550 nM -1.18935415188102 0.161321968919896 no 2874 0.117150167194999 4281 24132586
SGTC_1630 st005209 31.3 µM -1.19005932039821 0.161177087507701 no 2875 0.117011538760322 4262 3367314
SGTC_2234 tolnaftate 200 µM -1.19037827435432 0.161111584254845 no 2876 0.116948874089197 4345 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_626 0214-0009 33 µM -1.19172878851824 0.160834423037285 no 2877 0.116683803039447 4331 3437874
SGTC_2291 7917025 104.35 µM -1.1924409891936 0.160688386066841 no 2878 0.116544188127504 4179 2964612
SGTC_778 3456-2434 196 µM -1.19788888962684 0.159574158066035 no 2879 0.115480137817922 4230 5539063
SGTC_1764 st044502 93.5 µM -1.19876268778024 0.159395916814112 no 2880 0.115310117399882 4321 8407
SGTC_2383 9036125 200 µM -1.2005690772659 0.159027854848839 no 2881 0.114959201082004 4210 79580
SGTC_2945 9067681 61.76 µM -1.20252076978853 0.158630812915793 no 2882 0.114580911999822 4352 16456930
SGTC_2681 menadione 3.18 µM -1.20273485832431 0.158587299479247 no 2883 0.114539470023576 4306 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2987 9018338 71.43 µM -1.20372311027616 0.158386539007139 no 2884 0.114348308418934 4304 5055682
SGTC_189 3970-0742 2.116 µM -1.20384979341865 0.15836081576151 no 2885 0.114323820017756 4266 2891807
SGTC_2734 clemastine 41.6 µM -1.20469897799149 0.158188458034562 no 2886 0.114159765360991 4335 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1021 4476-0760 85.3 µM -1.20558946182669 0.158007850146926 no 2887 0.113987912244786 4298 746768
SGTC_2441 5730946 39.09 µM -1.20637635934437 0.157848364345638 no 2888 0.113836203563833 4340 1774275
SGTC_953 1188-0045 9.7 µM -1.20652467552924 0.157818315953811 no 2889 0.11380762530006 4295 6144426
SGTC_618 k072-0232 33.2 µM -1.21092466149288 0.156928601586876 no 2890 0.112962139979483 4344 5872756 YGL099W LSG1
SGTC_304 1310-0298 97 µM -1.21325711258712 0.156458301159471 no 2891 0.112515767223222 4072 1550234
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.21345374676779 0.156418695573078 no 2892 0.112478194031133 4382 4213774
SGTC_1104 tacrolimus 29.8 µM -1.21616272806383 0.155873731139194 no 2893 0.111961469441925 4355 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_128 0906-2981 13.371 µM -1.21717487109607 0.155670440408532 no 2894 0.111768844463924 4291 6740226
SGTC_1881 5652484 16 µM -1.21851447412758 0.155401647741154 no 2895 0.111514263915282 4281 2255129
SGTC_505 gw-5074 63.9 µM -1.22351155663761 0.154401681671813 no 2896 0.110568270972675 4336 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1816 st051957 91.6 µM -1.22384011381855 0.154336083483832 no 2897 0.110506274277268 4292 674121
SGTC_2984 9022109 38.96 µM -1.2270223526393 0.153701686299196 no 2898 0.10990709485804 4327 6459207
SGTC_1574 spiramycin 23.7 µM -1.22926006643218 0.15325662075249 no 2899 0.109487157247861 4270 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2 0422-0095 29 µM -1.23041167336862 0.15302790737352 no 2900 0.109271492104257 4209 6790840
SGTC_2404 5161160 200 µM -1.23132976013543 0.152845734135857 no 2901 0.109099777807975 4257 2831543
SGTC_2346 9031566 143.75 µM -1.23560088352562 0.152000119252087 no 2902 0.108303478067205 4285 4771086
SGTC_427 1354-0053 47.3 µM -1.23838813146528 0.151449966995918 no 2903 0.107786089631321 4369 6813657
SGTC_1563 conessine 56.1 µM -1.23953929285928 0.151223135408089 no 2904 0.107572923339076 4399 441082 An anti-amoebic, histamine inhibitor.
SGTC_556 4058-0063 51.5 µM -1.24370856035842 0.150403490838049 no 2905 0.106803422140249 4360 6615692
SGTC_1666 st014829 29 µM -1.24476044318088 0.150197167569117 no 2906 0.106609910291203 4312 3858230
SGTC_2155 5570423 76 µM -1.24739501648355 0.149681233212822 no 2907 0.106126346479136 4289 797402
SGTC_1995 st072814 61.1 µM -1.25133178709374 0.148912492640192 no 2908 0.105406726404763 4286 5769371
SGTC_1200 1643-0193 18.4 µM -1.25174526402267 0.148831905584147 no 2909 0.105331350410288 4343 5403974
SGTC_1476 4112-3294 3.34 µM -1.25254544262001 0.14867603278588 no 2910 0.105185590263808 4320 704369
SGTC_222 nsc-310342 10.666 µM -1.25434607144136 0.148325673979193 no 2911 0.104858122493449 4348 432556
SGTC_1753 st043925 64 µM -1.25627683049808 0.147950609042052 no 2912 0.10450780963553 4358 670181
SGTC_1643 st009866 20.2 µM -1.25742806968339 0.147727274278616 no 2913 0.104299335152163 4282 3156273 YOR207C RET1
SGTC_2611 pyromycin 23.93 µM -1.26500578346391 0.146262870593034 no 2914 0.102934627332551 4307 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3226 9131256 49.47 µM -1.26576090340195 0.146117478592076 no 2915 0.102799348162013 4301 17178073
SGTC_2570 licareol 100 µM -1.26612489483905 0.146047429787521 no 2916 0.10273418553488 4318 443158
SGTC_329 k048-0121 21.3 µM -1.26741999058649 0.145798376370748 no 2917 0.102502577785369 4362 6832902
SGTC_988 1497-1057 103 µM -1.27163529689929 0.14498972937411 no 2918 0.101751364780076 4318 3533044
SGTC_139 0099-0334 718.624 µM -1.27821994455542 0.14373260986605 no 2919 0.100585942836974 4370 97690
SGTC_3274 9138298 49.47 µM -1.27843119295377 0.143692401144207 no 2920 0.100548715698561 4324 17015756
SGTC_2330 7979373 200 µM -1.27869767434595 0.143641690280239 no 2921 0.100501769493108 4272 1863007
SGTC_2386 9075165 157.42 µM -1.28455099970409 0.142530860500489 no 2922 0.0994746155141915 4340 16452277
SGTC_3221 9128209 49.47 µM -1.2852337517336 0.142401668867196 no 2923 0.0993553062472471 4381 16460723
SGTC_186 3455-3465 67.277 µM -1.29016916742651 0.141470136417497 no 2924 0.0984959644087037 4369 755278
SGTC_193 1273-0060 1.558 µM -1.29105481312887 0.141303413667067 no 2925 0.0983423356829295 4191 2847393 YHR072W ERG7
SGTC_3310 9130229 44.1445 µM -1.29130179817382 0.141256942507371 no 2926 0.0982995236781815 4384 7761258
SGTC_2812 7970281 58.44 µM -1.2928225782714 0.140971030361544 no 2927 0.098036214773235 4390 2233435
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.29352895700678 0.140838362205377 no 2928 0.0979140878029233 4359 7104
SGTC_1281 0884-0031 11.8 µM -1.29393547237861 0.140762051145057 no 2929 0.097843855265962 4379 1548255
SGTC_1328 1441-0025 69.2 µM -1.29479035737768 0.140601663698577 no 2930 0.0976962796395926 4338 4562601
SGTC_2050 5263056 171 µM -1.3031135845934 0.139046602133193 no 2931 0.096267993237817 4349 763468 YGL055W OLE1
SGTC_2433 5607874 27.82 µM -1.30318334104388 0.139033618925665 no 2932 0.0962560880601304 4328 2252428
SGTC_1239 0337-0584 35.4 µM -1.30713315651308 0.138299817627055 no 2933 0.0955837461291166 4437 914301 YML130C ERO1
SGTC_1147 3809-1045 12.3 µM -1.30957810806207 0.137846916914284 no 2934 0.0951692991715308 4357 325925
SGTC_523 1934-0222 13.7 µM -1.31350168393856 0.137122234008204 no 2935 0.0945069769283498 4323 1361595
SGTC_1383 3049-0032 20.7 µM -1.31478459453998 0.136885846592009 no 2936 0.0942911531779337 4436 712864
SGTC_2593 nobiletin 86.24 µM -1.31605040961955 0.136652882303785 no 2937 0.0940785619001803 4370 72344 An anti-infammatory.
SGTC_2133 5320837 200 µM -1.32535070894861 0.134949542389997 no 2938 0.0925274287151199 4406 2841355
SGTC_1710 st031758 61.5 µM -1.32703423867771 0.134642769224344 no 2939 0.0922486784663691 4419 5394341
SGTC_3056 9094900 49.47 µM -1.3289778966066 0.13428919111402 no 2940 0.0919276311432934 4370 25236784
SGTC_839 0122-0028 230 µM -1.32940703141684 0.134211211604618 no 2941 0.0918568596500337 4415 759448
SGTC_2227 7312221 64.1025 µM -1.33095208045687 0.13393071322459 no 2942 0.0916023894726922 4504 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1765 st044815 90.4 µM -1.33156408442053 0.13381971746793 no 2943 0.091501736750598 4418 645695
SGTC_538 2922-0838 53.3 µM -1.33236001792834 0.133675458044202 no 2944 0.0913709568602358 4403 777039
SGTC_2189 6047310 154.431 µM -1.33251491582398 0.133647395920087 no 2945 0.0913455216910969 4365 711535
SGTC_328 k915-0120 63.5 µM -1.33356373218032 0.133457493353611 no 2946 0.0911734377976755 4398 6624543
SGTC_1745 st081495 74 µM -1.333601573882 0.133450645066004 no 2947 0.091167233440383 4242 13842402 YBL026W LSM2
SGTC_2121 5257820 149.641 µM -1.3338777439653 0.133400673338758 no 2948 0.0911219633005577 4422 791256
SGTC_2715 st079500 56.4 µM -1.33725791336884 0.132790089820837 no 2949 0.090569231864745 4371 28246688
SGTC_1722 st034304 3.6505 µM -1.34136852619285 0.132050158191538 no 2950 0.0899004155354577 4350 4036148 YLR033W RSC58
SGTC_3091 9116372 49.47 µM -1.3420156776039 0.131933927134103 no 2951 0.0897954562077553 4449 17169793
SGTC_3005 9076496 71.4286 µM -1.34276032579296 0.131800272590903 no 2952 0.0896747969418288 4369 21368410
SGTC_1303 1160-0052 261 µM -1.34340294816833 0.131685005453521 no 2953 0.0895707663919373 4335 3562476
SGTC_111 0083-0039 52.457 µM -1.34536043558087 0.131334319812353 no 2954 0.0892544327370511 4349 759313
SGTC_1862 st057513 3.81 µM -1.34747586668128 0.130956064018404 no 2955 0.0889135104342828 4386 5393163
SGTC_3300 9124615 50.48 µM -1.35050619876961 0.130415529309372 no 2956 0.0884268333315009 4438 24824903
SGTC_370 0180-0345 38.7 µM -1.35348504877068 0.129885683719354 no 2957 0.0879503616510609 4246 3989527
SGTC_3092 9117248 49.47 µM -1.35435924696341 0.129730474066269 no 2958 0.0878108963242313 4526 17141857
SGTC_904 1141-0088 396 µM -1.35462221860434 0.129683809866638 no 2959 0.0877689753997264 4412 1378119
SGTC_993 3909-8757 62.7 µM -1.35768167119293 0.129141765702722 no 2960 0.0872823575892467 4347 4288324 YLR208W SEC13
SGTC_1958 st076513 41.9 µM -1.35775905133876 0.129128076634254 no 2961 0.0872700761464039 4341 732122 YGL099W LSG1
SGTC_3014 9081533 49.47 µM -1.36100237543633 0.128555215370508 no 2962 0.0867564693858485 4437 21367265
SGTC_2468 5987765 72.9 µM -1.36595794827217 0.127683333938683 no 2963 0.0859760813189173 4468 26772094
SGTC_195 4234-0266 16.654 µM -1.36671181607827 0.127551059820714 no 2964 0.0858578263542058 4426 2303354
SGTC_1297 1068-0111 14.1 µM -1.36672402691901 0.127548918083355 no 2965 0.0858559119112985 4418 767057
SGTC_1223 0764-0573 147 µM -1.36846885496869 0.127243138573709 no 2966 0.0855826822052551 4411 1609797
SGTC_1219 1469-0211 33.1 µM -1.3691969680222 0.127115688362857 no 2967 0.0854688567653767 4414 6822282
SGTC_1693 xanthone 101.9 µM -1.37091853432188 0.126814695719406 no 2968 0.0852001764513693 4448 7020 An insecticide.
SGTC_602 3130-1533 38.1 µM -1.37150522000056 0.126712235098196 no 2969 0.0851087586997096 4463 720941
SGTC_1559 coumarin 343 70.1 µM -1.37153988056782 0.126706183672335 no 2970 0.0851033601677117 4461 108770 A hepatotoxic, DNA x-linker.
SGTC_3135 9127742 49.47 µM -1.37314726244393 0.126425770185556 no 2971 0.0848532853626898 4483 3643468
SGTC_3329 9141233 27.5565 µM -1.37641036488375 0.125857840903761 no 2972 0.0843473104143359 4380 4909101 YNL103W MET4
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.38279961237425 0.124750977853365 no 2973 0.0833631589447035 4414 689007
SGTC_2338 7999974 200 µM -1.38623708959016 0.124158297442092 no 2974 0.0828372597759533 4425 315925
SGTC_2553 4-methylesculetin 85.09 µM -1.38990776648266 0.123527587320802 no 2975 0.0822784434641329 4442 5319502
SGTC_3048 9093155 49.47 µM -1.39186507772764 0.123192193246075 no 2976 0.0819816293415403 4389 25236002
SGTC_2871 9038510 12.99 µM -1.39290692479376 0.123013928558828 no 2977 0.0818239690660529 4404 4945164
SGTC_2939 9044578 71.43 µM -1.39293850803186 0.123008527351262 no 2978 0.0818191932199149 4355 2653634
SGTC_2676 harmalol 100 µM -1.39342714088738 0.122924984984766 no 2979 0.0817453315745676 4387 5459187 A monoamine oxidase inhibitor
SGTC_3023 9089636 49.47 µM -1.39401867324439 0.122823902961558 no 2980 0.0816559829279135 4511 17249241
SGTC_510 ag-490 170 µM -1.39534288167431 0.122597831385359 no 2981 0.0814562333545366 4559 5328779
SGTC_591 4299-0174 154 µM -1.39857887957722 0.122046604029746 no 2982 0.0809696517327141 4470 5509088
SGTC_1628 st004252 77.7 µM -1.40245989538807 0.121387801265506 no 2983 0.0803889791842306 4445 692968
SGTC_713 1488-1073 324 µM -1.40359678465813 0.121195288587474 no 2984 0.0802194765685084 4472 3312542
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.40698682661444 0.12062251835741 no 2985 0.0797156475402382 4507 4620898
SGTC_1036 k216-0215 33.5 µM -1.40852434315655 0.120363373852404 no 2986 0.0794879319523287 4388 622330
SGTC_53 0973-0023 39.979 µM -1.4167228435892 0.118988158519074 no 2987 0.0782819877746879 4346 674768
SGTC_2211 7117706 200 µM -1.41703565759423 0.118935907787343 no 2988 0.0782362512664513 4383 822771
SGTC_1492 4158-0558 28.5 µM -1.41738585623947 0.118877431757075 no 2989 0.0781850728004065 4449 3967268
SGTC_3043 9092303 49.47 µM -1.42073690974952 0.118318900833114 no 2990 0.0776966290131285 4453 25236084
SGTC_192 3455-0609 60.9 µM -1.42567444677244 0.117499330358729 no 2991 0.0769811679240412 4515 3769639
SGTC_3070 9117005 49.47 µM -1.42731402892809 0.117228070907129 no 2992 0.0767446993351422 4547 8779016
SGTC_765 1319-0117 244 µM -1.42813699473698 0.117092083274138 no 2993 0.0766262155540407 4423 3487746 YGL099W LSG1
SGTC_748 act1.228 77.9 µM -1.42986917008977 0.116806222310552 no 2994 0.0763772859805074 4434 4421505 YNR035C ARC35
SGTC_3315 9136395 68.55 µM -1.43039249309283 0.116719955687102 no 2995 0.076302200796852 4437 16876844
SGTC_1435 4092-0789 56.7 µM -1.43117905869144 0.116590380104203 no 2996 0.0761894518485894 4453 2248285
SGTC_2152 5568786 200 µM -1.43492436071851 0.115974793791008 no 2997 0.0756543264966973 4473 5399883
SGTC_3098 9119039 49.47 µM -1.43571180435526 0.115845661884515 no 2998 0.0755421824371323 4458 17161528
SGTC_2214 7179297 48.276 µM -1.43671952735466 0.115680555620529 no 2999 0.0753988520448247 4523 769744
SGTC_2760 etidronate 98.04 µM -1.43909442001052 0.115292112326962 no 3000 0.0750618863925535 4409 3305 A chelator and antioxidant.
SGTC_1385 3091-4834 14.1 µM -1.43970288910768 0.115192738996016 no 3001 0.0749757378223866 4445 4072814
SGTC_669 0108-0021 26.2 µM -1.44051116198886 0.115060828507064 no 3002 0.0748614171861227 4472 17201
SGTC_121 0557-0495 61.343 µM -1.44073078063351 0.115025005213295 no 3003 0.0748303777140783 4501 3104427
SGTC_295 k015-0027 31 µM -1.44254629671364 0.114729169443427 no 3004 0.0745741604365764 4524 3887424
SGTC_3147 9097027 49.47 µM -1.44387920110404 0.114512319470879 no 3005 0.0743864790786664 4473 25236841
SGTC_2643 anethole 100 µM -1.44432773493828 0.11443941323 no 3006 0.0743234038462018 4463 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_403 arphamenine a 50 µM -1.44468210256157 0.11438183646128 no 3007 0.0742735996570261 4471 5487158 An arginine aminopeptidase inhibitor.
SGTC_601 0986-0029 62.9 µM -1.44624473151683 0.114128190393589 no 3008 0.0740542857120026 4431 24747981
SGTC_1344 1488-0097 29.1 µM -1.44626414054532 0.114125042439425 no 3009 0.0740515647816476 4490 747966
SGTC_345 1362-0200 395 µM -1.4463692116115 0.114108002016106 no 3010 0.0740368363103207 4451 1419823
SGTC_2481 5478948 45.16 µM -1.44726477935071 0.113962832413333 no 3011 0.0739113897747049 4458 77792
SGTC_1856 st057054 55.7 µM -1.45034054944375 0.113465258862436 no 3012 0.0734817883302662 4446 1266018
SGTC_659 k018-0002 107 µM -1.45038063401017 0.113458784543772 no 3013 0.0734762022383238 4436 6797879 YHR007C ERG11
SGTC_1091 telmisartan 47.6 µM -1.45222202714211 0.113161653153407 no 3014 0.073219939933515 4488 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2222 6885208 172.143 µM -1.45412690538058 0.112854862347989 no 3015 0.0729555627024229 4478 609514
SGTC_1986 st071812 45 µM -1.45661562625505 0.112454935855283 no 3016 0.0726112558932202 4406 11838594
SGTC_3028 9087778 49.47 µM -1.45675915202593 0.112431902813215 no 3017 0.0725914375685109 4444 17217395
SGTC_934 2950-0684 338 µM -1.45852355385012 0.112149026645257 no 3018 0.0723481438435961 4475 1121253
SGTC_3327 9140648 26.9345 µM -1.46064124893277 0.111810181219397 no 3019 0.072056959999065 4487 8029710
SGTC_2116 5511452 16.8835 µM -1.46394159018497 0.111283565324832 no 3020 0.0716049541874024 4484 870744
SGTC_3219 9131112 49.47 µM -1.46592913848532 0.11096728194499 no 3021 0.0713337963728557 4343 17612988 YMR079W SEC14
SGTC_1143 3454-2408 5.08 µM -1.46706596478996 0.11078666574841 no 3022 0.0711790558435098 4481 X1143
SGTC_2111 5486399 200 µM -1.46991446238552 0.110335028766221 no 3023 0.0707924610578932 4446 689674
SGTC_1515 3460-0031 42.1 µM -1.4719725175922 0.110009541135887 no 3024 0.0705141495444673 4450 2876596
SGTC_1459 k035-0031 35.7 µM -1.47587144691552 0.109394803780948 no 3025 0.0699892029847044 4207 3877128 YMR208W ERG12
SGTC_2006 4011487 200 µM -1.47594221314845 0.109383669037648 no 3026 0.0699797029739315 4444 45595294
SGTC_842 0271-0008 11.1 µM -1.47914614837284 0.10888039697263 no 3027 0.0695506292903975 4503 1221709
SGTC_2465 5809242 33.21 µM -1.48975503830485 0.107225846563806 no 3028 0.0681443285738072 4566 2731748
SGTC_91 0417-1751 58.384 µM -1.49145494464357 0.106962425277411 no 3029 0.0679210459305945 4584 6795624
SGTC_1950 st077106 7.18 µM -1.49268680749885 0.106771824996249 no 3030 0.0677595941358014 4395 13831864
SGTC_1777 st045864 34.765 µM -1.50056122291172 0.105559242861067 no 3031 0.0667345436176592 4499 4691462
SGTC_1458 k015-0034 6.33 µM -1.50777889826231 0.104456567895251 no 3032 0.0658055623003195 4521 3598957
SGTC_1962 st076595 64.5 µM -1.50787743366893 0.104441572188363 no 3033 0.0657929495968248 4465 279619
SGTC_990 3985-0011 41.3 µM -1.51123322358365 0.103931798834929 no 3034 0.0653645202294806 4468 5399565 YGL099W LSG1
SGTC_2736 butenafine 14.65 µM -1.51675021217483 0.103097646857441 no 3035 0.064664880808131 4453 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_678 1218-2179 85.9 µM -1.52490671909704 0.101873332572689 no 3036 0.0636411828714968 4548 6820081 YOR116C RPO31
SGTC_3018 9082602 49.47 µM -1.52645794433045 0.101641691984687 no 3037 0.0634479282344814 4426 17332089
SGTC_553 k007-0256 45.7 µM -1.52844319696546 0.101345798971014 no 3038 0.063201268320872 4560 6287000
SGTC_2213 7173844 200 µM -1.52979811533423 0.10114421506783 no 3039 0.0630333541324559 4520 892728
SGTC_1391 3442-0225 151 µM -1.53100029337237 0.100965600570197 no 3040 0.0628846600722801 4489 5227075
SGTC_824 1304-0008 100 µM -1.53151293195869 0.100889504883645 no 3041 0.0628213364042749 4534 768245
SGTC_1978 st071761 42 µM -1.53250339311161 0.100742600032966 no 3042 0.062699130463282 4510 5147680
SGTC_1377 2944-0135 198 µM -1.53889637593642 0.099798146762012 no 3043 0.0619147980346944 4518 1894137
SGTC_1845 st056753 3.01 µM -1.54014117953584 0.0996150031997443 no 3044 0.0617629719681271 4478 5375839
SGTC_2027 5150920 200 µM -1.54425385673993 0.0990116657675066 no 3045 0.0612634231491407 4474 786715
SGTC_811 0416-0114 265 µM -1.54612212178017 0.0987384724712324 no 3046 0.0610375385601302 4535 6612453
SGTC_2682 pyrogallin 40.03 µM -1.55037172758438 0.0981191150318749 no 3047 0.0605261601965188 4529 822798 An ATP competetive kinase inhibitor.
SGTC_2838 9002687 71.43 µM -1.55263100685198 0.0977909982542712 no 3048 0.0602556568004223 4503 6457060
SGTC_2618 avocadyne 43.43 µM -1.55409442933252 0.0975788940128278 no 3049 0.0600809469042705 4462 3015189
SGTC_2250 alverine citrate 130 µM -1.55658552176161 0.0972186184929657 no 3050 0.0597844617243631 4395 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3 0833-0587 95.581 µM -1.56455151276468 0.0960730853833436 no 3051 0.0588440527612841 4417 5382644
SGTC_1990 st072050 59.8 µM -1.56674633752498 0.0957592139789986 no 3052 0.0585869975308674 4515 17233948
SGTC_2779 methotrexate 400 µM -1.57053591002589 0.0952190620880476 no 3053 0.0581452434503529 4512 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1416 3966-0321 25.3 µM -1.57294359416305 0.0948770470643566 no 3054 0.0578659398053558 4581 582530 YLR208W SEC13
SGTC_1145 3546-0597 10.2 µM -1.5734261020296 0.0948086151289283 no 3055 0.0578100934970965 4516 875334
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.57367767518663 0.0947729500603092 no 3056 0.0577809927884011 4507 97141
SGTC_2784 7567673 72.73 µM -1.57923354562948 0.0939878228415668 no 3057 0.0571412490954415 4456 3471247
SGTC_3319 9138450 16.7555 µM -1.58099600315031 0.0937397669209568 no 3058 0.056939475804887 4467 2029690
SGTC_2016 5121758 140 µM -1.58166792693018 0.0936453248167369 no 3059 0.0568626991197997 4462 2795203
SGTC_521 r062-0005 13.8 µM -1.58776935375489 0.0927909536732419 no 3060 0.0561692518825311 4474 2832033
SGTC_2334 9017922 200 µM -1.5881884120605 0.0927324859750513 no 3061 0.0561218703247756 4557 3163164
SGTC_770 0389-1121 67.2 µM -1.59279047731119 0.0920921899613331 no 3062 0.055603601057039 4569 6753108
SGTC_846 0335-0850 148 µM -1.59654456883903 0.0915723033213969 no 3063 0.0551836317137088 4531 6819598
SGTC_3029 9088683 49.47 µM -1.59994498852204 0.0911032751071582 no 3064 0.0548053938871555 4547 25236615
SGTC_615 k087-0205 167 µM -1.60758574986481 0.090055869902976 no 3065 0.0539629676209155 4562 9642773
SGTC_2168 5727979 200 µM -1.61135520798853 0.0895424554869303 no 3066 0.0535511620455785 4467 695210
SGTC_1181 1222-0449 220 µM -1.61226196056497 0.0894192777820262 no 3067 0.053452473618612 4574 658318
SGTC_3211 9128781 49.47 µM -1.61230684544196 0.089413183676357 no 3068 0.0534475922194542 4466 17194361
SGTC_1451 4152-0210 104 µM -1.61255893737606 0.0893789624118271 no 3069 0.0534201828365849 4579 659563
SGTC_2966 9084041 48.03 µM -1.61437823584807 0.0891322830256408 no 3070 0.0532227047747735 4501 17741380
SGTC_3209 9113616 49.47 µM -1.61776038813797 0.0886750427469215 no 3071 0.0528571230752354 4587 16649353
SGTC_2877 9040724 71.43 µM -1.61831196100391 0.0886006404308522 no 3072 0.052797692138613 4515 6463895
SGTC_1616 st002734 56.1 µM -1.62395037661333 0.0878427334232686 no 3073 0.0521931998732429 4535 4026101
SGTC_509 pifithrin 175 µM -1.62735723313011 0.087387138723678 no 3074 0.0518306244861265 4643 4817 A p53 inhibitor.
SGTC_1314 1222-0010 41.1 µM -1.62875039250887 0.0872013422066679 no 3075 0.0516829350930724 4555 3526027
SGTC_1431 4049-0260 9.09 µM -1.63858728129409 0.0858978472572386 no 3076 0.0506496214766438 4590 3854841
SGTC_269 exalamide 29 µM -1.64417416511333 0.0851640466236271 no 3077 0.0500701159003965 4546 3316 A derivative of salicylamide.
SGTC_69 0096-0274 206.684 µM -1.64740268061513 0.0847421493021862 no 3078 0.0497376523749932 4610 6741392
SGTC_1197 1601-0112 267 µM -1.6511700874932 0.0842518143287589 no 3079 0.0493519245867872 4537 7350313
SGTC_2900 5328528 85.29 µM -1.65421772968031 0.0838567185357552 no 3080 0.0490416408755899 4560 795359
SGTC_1909 st060837 51.5 µM -1.65509760989673 0.0837429102925696 no 3081 0.0489523498218075 4513 678937
SGTC_2771 fluoxetine 41.05 µM -1.65904138877796 0.0832342267988993 no 3082 0.0485537262330841 4566 3386 A selective serotonin reuptake inhibitor.
SGTC_83 0170-0301 39.027 µM -1.65991251462736 0.0831221796023428 no 3083 0.0484660267416482 4595 3089716
SGTC_698 k064-0052 127 µM -1.66446597964132 0.0825383426813701 no 3084 0.04800967211067 4652 5088751
SGTC_1913 st060213 96.1 µM -1.66503268088639 0.0824658978244656 no 3085 0.0479531179607743 4547 688959
SGTC_1748 st037455 53.6035 µM -1.67398929193029 0.0813272685074854 no 3086 0.0470663519255693 4572 580690
SGTC_2943 9068529 45.32 µM -1.67856000044428 0.0807507965977334 no 3087 0.0466189138250477 4532 3270634
SGTC_508 roscovitine 141 µM -1.68088484864006 0.0804587659659717 no 3088 0.0463926417405188 4641 160355 A CDKinase inhibitor.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.68216677001424 0.0802980819083382 no 3089 0.046268252912018 4584 2374 Ca(2+)-ATPase inhibitor.
SGTC_1046 2001-0062 216 µM -1.68351145647564 0.0801297912128738 no 3090 0.0461380617281909 4537 739778
SGTC_1550 gossypolone 36.6 µM -1.68455917780784 0.0799988513119752 no 3091 0.0460368264797244 4601 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3326 9140064 16.379 µM -1.68880371252123 0.0794700417585038 no 3092 0.0456285260758228 4533 1868434
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.69073079723385 0.0792308289823921 no 3093 0.0454441147564026 4656 16725076
SGTC_1964 st076914 61 µM -1.69106103239032 0.0791898910219688 no 3094 0.0454125733246934 4619 24208661
SGTC_2388 9080168 200 µM -1.69880144071405 0.078234923898826 no 3095 0.0446783010443964 4614 15943073
SGTC_1608 st001473 40.5 µM -1.70250617195663 0.0777809575255305 no 3096 0.0443302612376634 4561 7292267
SGTC_1079 idarubicin 2.36 µM -1.70305626737262 0.0777137213526377 no 3097 0.0442787695033245 4614 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3165 9101544 49.47 µM -1.7060542787916 0.0773480605020003 no 3098 0.0439989870556896 4583 5002184
SGTC_2884 9058502 51.95 µM -1.71546102786399 0.0762092220369816 no 3099 0.0431303673615984 4573 6471554
SGTC_155 k072-0202 43.6 µM -1.71606090013313 0.0761370330182944 no 3100 0.0430754483051133 4588 5857737
SGTC_2046 4110841 106 µM -1.71659995234259 0.0760722075383037 no 3101 0.0430261456047274 4604 44119630 YMR134W ERG29
SGTC_2930 9013230 14.89 µM -1.71814410032288 0.0758867435682043 no 3102 0.0428851673170806 4563 2995857
SGTC_331 k048-0133 24.5 µM -1.7189925872512 0.0757849804974733 no 3103 0.0428078608489194 4604 6813582
SGTC_855 0428-0020 25 µM -1.72118930429108 0.07552200068841 no 3104 0.0426082390242385 4619 6812414
SGTC_2823 7987624 58.44 µM -1.7212522947459 0.0755144700598775 no 3105 0.0426025260249744 4528 2239440
SGTC_2305 7443522 69.23 µM -1.73057235336954 0.0744065331542427 no 3106 0.0417640330936134 4506 5415886
SGTC_444 curcumin 90.4 µM -1.73194654316801 0.0742442294306913 no 3107 0.0416415403754941 4509 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1 0258-0098 57.368 µM -1.73652724136325 0.0737051617561423 no 3108 0.0412353259618588 4526 6790032 YDR047W HEM12
SGTC_68 0986-0284 82.829 µM -1.73727905805978 0.0736169726990599 no 3109 0.0411689630875558 4547 423278 YIL048W NEO1
SGTC_1098 clofazimine 15.1 µM -1.73839867925232 0.0734857892658955 no 3110 0.0410702946324334 4636 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1713 st033146 12.748 µM -1.73922575850955 0.0733889971560355 no 3111 0.0409975301406723 4570 674619
SGTC_1284 0929-0043 16 µM -1.74093321416907 0.0731894841160622 no 3112 0.0408476429383377 4609 1239883
SGTC_172 1112-0046 2.638 µM -1.74344793949464 0.0728963991391253 no 3113 0.0406277002813878 4596 2802135 YIL048W NEO1
SGTC_1177 0983-0204 23.6 µM -1.74428764406918 0.0727987340101643 no 3114 0.0405544725478886 4646 766818
SGTC_1073 triclabendazole 3.09 µM -1.74526359318194 0.072685348347591 no 3115 0.0404694980646072 4642 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_524 r073-0010 27.8 µM -1.75090382718456 0.0720327141205126 no 3116 0.0399812387259729 4560 2772106
SGTC_1061 3448-9325 110 µM -1.76055229903819 0.0709267135679393 no 3117 0.0391571041362064 4576 723482
SGTC_1980 st071811 45.7 µM -1.7630560617346 0.070641850946886 no 3118 0.0389455174053795 4656 4974850
SGTC_610 4215-0184 155 µM -1.76341701666786 0.0706008563482544 no 3119 0.0389150909326304 4626 5605015
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.76701134612985 0.070193635913155 no 3120 0.0386131640776871 4622 5393153
SGTC_663 1486-0733 13.9 µM -1.77012132795553 0.0698427496672165 no 3121 0.0383534656559566 4618 722445 YPR165W RHO1
SGTC_862 0452-0056 10.2 µM -1.77122198965445 0.0697188905449899 no 3122 0.038261896971971 4576 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_472 calcifediol 10 µM -1.77720238980956 0.0690488602780176 no 3123 0.0377674732033417 4648 5283731 A vitamin D metabolite.
SGTC_62 0180-0423 3.232 µM -1.78490781688951 0.0681928915564017 no 3124 0.0371381352651577 4567 30102 YGL099W LSG1
SGTC_123 0083-0120 66.675 µM -1.7881216400244 0.0678383090002501 no 3125 0.0368781924961248 4599 16001701
SGTC_1338 1486-1223 76 µM -1.7943772518671 0.0671522098228863 no 3126 0.0363764876384749 4631 3444526
SGTC_1744 st037937 38.9 µM -1.79439503822775 0.0671502667396341 no 3127 0.036375069163184 4639 1016152
SGTC_2099 5377090 177.372 µM -1.79473493473314 0.0671131428644525 no 3128 0.036347970865563 4603 2243829
SGTC_284 0988-0104 32.6 µM -1.79555770728262 0.0670233444391276 no 3129 0.0362824436102677 4609 4666532
SGTC_1642 st009582 77.7 µM -1.79615202987475 0.0669585371557615 no 3130 0.0362351707476716 4621 6739311
SGTC_381 3461-2219 42.7 µM -1.80049633183056 0.0664862884632484 no 3131 0.0358911511368289 4611 2883159
SGTC_1834 st055981 52.8 µM -1.80053904580964 0.0664816580610237 no 3132 0.0358877820028272 4604 471719 YDL150W RPC53
SGTC_1023 4482-3888 16 µM -1.80096180790238 0.0664358420651252 no 3133 0.0358544499318501 4622 3303168
SGTC_907 3448-6986 75.5 µM -1.80924704650125 0.0655428716142143 no 3134 0.0352063158067788 4628 590582
SGTC_1617 st002906 78 µM -1.8131318972683 0.0651273865514799 no 3135 0.0349057402681883 4621 5150859
SGTC_137 0438-0332 85.389 µM -1.8213971798412 0.0642502166742866 no 3136 0.0342732517813534 4577 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1439 4092-1168 46 µM -1.82199000453427 0.064187656585844 no 3137 0.0342282511528266 4655 2886240
SGTC_325 2810-4341 181 µM -1.82811147102445 0.0635444311314031 no 3138 0.0337664118608811 4644 774970
SGTC_1984 st072354 53.1 µM -1.83936202700182 0.0623753501283889 no 3139 0.0329309777181441 4550 5762938
SGTC_2872 9044037 25.97 µM -1.83940447795636 0.0623709708955118 no 3140 0.0329278579911658 4687 6465195
SGTC_848 0368-0089 85.6 µM -1.84123029428017 0.0621828468293021 no 3141 0.0327939088446625 4639 762535
SGTC_502 l-744,832 89.3 µM -1.84151775007271 0.0621532690232778 no 3142 0.0327728609315931 4649 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2750 bromebric acid 70.15 µM -1.84269494822213 0.062032255540383 no 3143 0.0326867810131856 4618 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1423 4048-0112 5.59 µM -1.84513269619648 0.061782244808701 no 3144 0.0325091190076388 4674 X1423
SGTC_2471 5466956 24.79 µM -1.84526531376394 0.0617686663993207 no 3145 0.0324994767879704 4658 724419
SGTC_2301 7769476 200 µM -1.84867245449339 0.0614206152074594 no 3146 0.032252561743876 4638 977820
SGTC_833 3852-0053 558 µM -1.84979045505579 0.0613067420082623 no 3147 0.0321718785529338 4675 3123681
SGTC_585 0kpi-0023 191 µM -1.85331834479183 0.060948492404192 no 3148 0.0319183716531378 4596 64601
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.85643475080265 0.0606333913954484 no 3149 0.0316958076648997 4608 6857784
SGTC_480 am 92016 50 µM -1.85821510765205 0.0604539516048708 no 3150 0.0315692367245396 4653 2129 K+ channel blocker.
SGTC_2830 7992007 71.43 µM -1.8618679922371 0.0600870833740267 no 3151 0.03131084984823 4559 1952075
SGTC_2537 larixol 68.93 µM -1.86307502303609 0.0599662422054195 no 3152 0.0312258558796553 4616 6708759
SGTC_1525 8-methoxypsoralen 92.5 µM -1.86343886426553 0.0599298538142696 no 3153 0.0312002731922105 4647 4114 Related to psoralen; DNA damaging agent.
SGTC_1743 st037606 46.3785 µM -1.86810958837702 0.0594642611120403 no 3154 0.0308733986661444 4610 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_943 3253-1379 105 µM -1.86855989806555 0.0594195230760199 no 3155 0.030842034699519 4610 668464
SGTC_607 4491-0986 66.8 µM -1.88354393351424 0.0579458594326658 no 3156 0.0298133459087137 4643 698981 YDR232W HEM1
SGTC_1285 0929-0069 65.5 µM -1.88678747443704 0.0576306748631734 no 3157 0.0295944582531268 4678 1206237
SGTC_2586 curcumin 80 µM -1.8892656092078 0.0573907768942408 no 3158 0.0294281236469622 4555 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.89157321895532 0.057168093859634 no 3159 0.0292739334657033 4667 75037 A free radical scavenger.
SGTC_2693 st077581 40.7 µM -1.89569265457371 0.0567722618839163 no 3160 0.0290003485934611 4610 25238761
SGTC_1418 3966-3099 2.4 µM -1.90146573063177 0.0562211697398288 no 3161 0.0286205185349575 4670 740335
SGTC_1522 st012842 45.6 µM -1.90350577492971 0.0560274407641326 no 3162 0.0284872904341951 4505 3491067 YOR116C RPO31
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.90671818924482 0.0557234476262499 no 3163 0.0282785451397744 4645 688798
SGTC_2658 polymyxin b sulfate 77.05 µM -1.91642096423256 0.0548131649539787 no 3164 0.0276557672367548 4687 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1835 st008666 49.2 µM -1.917394348968 0.0547224976880665 no 3165 0.0275939258081279 4642 690455
SGTC_1513 0337-0559 19 µM -1.92117868957022 0.0543711261248538 no 3166 0.0273545919115091 4633 775073
SGTC_2436 5633522 8.09 µM -1.92213116767244 0.0542829713894257 no 3167 0.0272946275834439 4646 5724242
SGTC_531 3788-1495 174 µM -1.92303679238673 0.0541992579931001 no 3168 0.0272377146864357 4654 2896655
SGTC_1152 3909-8331 15.9 µM -1.92659735770065 0.0538711193637141 no 3169 0.0270149141052239 4677 16001939
SGTC_3278 9139605 49.47 µM -1.93088496195228 0.0534780672793632 no 3170 0.0267486401392778 4637 7958859
SGTC_481 bay k-8644 50 µM -1.93465115795272 0.0531346913216153 no 3171 0.0265165588606188 4644 2303 A calcium channel antagonist.
SGTC_1433 4060-0023 7.6 µM -1.93777585203276 0.0528511319221322 no 3172 0.0263252875528544 4699 3840627
SGTC_2968 9090663 33.37 µM -1.94003306160394 0.0526470426979865 no 3173 0.0261878360109301 4616 25236811
SGTC_983 1491-0821 12.2 µM -1.94680954271568 0.0520380916960684 no 3174 0.0257787862402867 4676 46495113
SGTC_1670 st016595 4.04 µM -1.95021553391077 0.0517341412055981 no 3175 0.0255752175405522 4690 597879
SGTC_919 tnp00227 403.569 nM -1.95290882265873 0.0514947928064123 no 3176 0.0254152000449851 4628 1269246 A methoxyflavone. YNL221C POP1
SGTC_324 1315-0088 19.6 µM -1.95477089835912 0.0513298285113119 no 3177 0.0253050587671139 4669 6787421
SGTC_3121 9125696 49.47 µM -1.9663433965786 0.050314006961292 no 3178 0.0246294785584402 4745 1235365
SGTC_78 0336-0123 156.75 µM -1.96757538261718 0.0502068147842918 no 3179 0.0245584572578914 4570 6765896
SGTC_2786 7743617 45.45 µM -1.9781423545183 0.0492948674249246 no 3180 0.0239563248171839 4610 583674
SGTC_1056 3448-1962 115 µM -1.97886293802119 0.0492331647385187 no 3181 0.023915720009572 4636 715507
SGTC_248 streptozotocin 5.23457 mM -1.98066318331331 0.0490792814296699 no 3182 0.0238145290742587 4704 5300 DNA alkylating agent.
SGTC_1326 1431-2094 10.8 µM -1.98864985589081 0.0484012155921363 no 3183 0.0233699321734001 4684 616278
SGTC_1587 estradiol valerate 56.1 µM -1.98945348338323 0.0483334047969133 no 3184 0.0233255856587619 4716 13791 A steroid.
SGTC_1725 st036284 20.55 µM -1.99143796426491 0.048166278056492 no 3185 0.0232163794955464 4659 707914
SGTC_2293 7624732 200 µM -1.99874208787403 0.0475551270993715 no 3186 0.0228181333256167 4582 894453
SGTC_399 oxolinic acid 75 µM -2.00032114786378 0.0474238239977309 no 3187 0.0227327984321354 4668 4628 A DNA gyrase inhibitor.
SGTC_2571 chrysanthemic acid 100 µM -2.00654207373319 0.0469093612448531 no 3188 0.0223992222587904 4662 2743 An insecticide.
SGTC_2377 9073351 62.6 µM -2.01567806467183 0.0461619501291642 no 3189 0.0219168253970703 4675 7337946 YHR072W ERG7
SGTC_1578 josamycin 24.2 µM -2.01968394546048 0.0458372613514696 no 3190 0.0217080907198176 4686 5282165 A P450 substrate.
SGTC_2689 tacrolimus 100 µM -2.01978450666401 0.0458291342362876 no 3191 0.0217028724555615 4666 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_191 3914-0123 66.505 µM -2.02023138108147 0.0457930329239416 no 3192 0.0216796963212523 4725 3144412
SGTC_2013 4024628 200 µM -2.02615936521091 0.0453162925270753 no 3193 0.0213742281074156 4683 5230760
SGTC_2389 9091542 195.52 µM -2.0307499179185 0.0449498607399705 no 3194 0.0211401848880268 4669 3626624 YOL127W RPL25
SGTC_1024 4507-0395 26 µM -2.04003644351195 0.0442158760145493 no 3195 0.0206733480434402 4702 4201836
SGTC_374 0880-0231 82.3 µM -2.04046396223969 0.0441823199643031 no 3196 0.0206520684376219 4583 6833587
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.04147153076792 0.0441033168647613 no 3197 0.0206019904151236 4685 23665772 A membrane-active detergent.
SGTC_660 4031-1742 102 µM -2.05170302751219 0.0433075029772134 no 3198 0.0200992661765123 4595 6738706
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.05774925645456 0.0428426994889629 no 3199 0.0198071046984479 4671 6728940
SGTC_1242 0402-0103 60.1 µM -2.05964447826579 0.0426978371866441 no 3200 0.0197162704212054 4634 432868
SGTC_2836 9010338 19.48 µM -2.06349002529169 0.0424051176328299 no 3201 0.0195330472648022 4637 2994051
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.08595335802032 0.0407275125071477 no 3202 0.0184914241176288 4661 279621
SGTC_2490 carminic acid 95.39 µM -2.0872313888547 0.0406337094508598 no 3203 0.0184336117000097 4691 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3026 9090633 49.47 µM -2.09451702786055 0.0401023125696553 no 3204 0.0181069739115172 4709 25236842
SGTC_435 c-PAF 6.7 µM -2.09486671658128 0.0400769498002812 no 3205 0.0180914211555786 4620 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2781 5567276 71.43 µM -2.10853031496691 0.0390960952409322 no 3206 0.0174925716966835 4677 2853274
SGTC_821 1114-0266 29.2 µM -2.11489324648008 0.038646042221707 no 3207 0.0172195234629396 4722 3123235
SGTC_2624 nerol 100 µM -2.11716552574586 0.0384863493637622 no 3208 0.0171229010509904 4636 637566 A natural product oil.
SGTC_1050 3232-1156 69.3 µM -2.13650791545221 0.0371486570937823 no 3209 0.0163190182433668 4697 700529
SGTC_2217 6934799 96.0675 µM -2.13862159451671 0.0370048093830453 no 3210 0.0162331635778458 4707 675606
SGTC_1318 1280-3875 124 µM -2.14020750982372 0.0368971781980068 no 3211 0.016169000269319 4724 373245
SGTC_617 3770-0098 35 µM -2.14335507869047 0.0366843204930019 no 3212 0.0160422986285989 4662 5962639
SGTC_1596 piperlongumine 63 µM -2.14814229712447 0.0363625061990316 no 3213 0.015851226496515 4723 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1376 2910-0861 41.3 µM -2.1584773965136 0.0356756195251853 no 3214 0.0154453669752734 4675 1112859
SGTC_2385 9074692 200 µM -2.1629808286278 0.0353796592202121 no 3215 0.0152713270906068 4706 17046906
SGTC_937 3122-0005 46.7 µM -2.16588691688099 0.0351897455920783 no 3216 0.0151599146516409 4696 759535
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.17096220360973 0.0348600804285449 no 3217 0.0149670147897478 4702 1377
SGTC_29 0299-0004 12.984 µM -2.18653591056296 0.0338642849251723 no 3218 0.0143882101998548 4671 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2780 5215298 71.43 µM -2.18813101593756 0.033763627044858 no 3219 0.0143300301152716 4719 2834131
SGTC_431 k089-0097 107 µM -2.19334467611525 0.0334363390384222 no 3220 0.0141412775399211 4442 5499420
SGTC_3141 9094609 49.47 µM -2.1965095401657 0.0332389416006095 no 3221 0.0140277465390909 4679 25236309 YDL196W YDL196W
SGTC_2897 9048598 12.99 µM -2.20461454071566 0.032737793698625 no 3222 0.0137405772672713 4709 6467404
SGTC_693 4161-2696 114 µM -2.21072134821576 0.0323643272673621 no 3223 0.0135275696299116 4744 805759
SGTC_707 0865-0008 204 µM -2.21791960822066 0.0319286335862132 no 3224 0.0132801571474372 4762 723043
SGTC_309 k408-0051 1.48 µM -2.22641503118853 0.0314206696573618 no 3225 0.0129931972907638 4662 3640463
SGTC_1105 epirubicin 18.1 µM -2.23456223066839 0.0309398213911035 no 3226 0.0127230513810586 4741 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2809 7964133 12.99 µM -2.23810792567809 0.0307324644999317 no 3227 0.0126070089690472 4696 1253665
SGTC_2049 5262831 67.185 µM -2.24341986971228 0.0304239692485985 no 3228 0.0124348758841454 4697 763417
SGTC_188 3229-0966 278.469 µM -2.24568145805424 0.0302934066973802 no 3229 0.0123622093364006 4760 5722370
SGTC_2811 7967822 32.47 µM -2.26375312069229 0.0292667138675271 no 3230 0.0117946516476066 4727 2232244
SGTC_3120 9124077 49.47 µM -2.27109117869263 0.0288581536184276 no 3231 0.0115707294488358 4781 18774327 YGL155W CDC43
SGTC_2365 9042475 200 µM -2.28915776381642 0.027872432825338 no 3232 0.0110350938085027 4725 6464479
SGTC_261 5-fluorouridine 15.376 µM -2.29835080734794 0.0273817230045969 no 3233 0.010770915456714 4747 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_339 3091-4833 71.4 µM -2.3059747927954 0.0269802514416716 no 3234 0.0105560204348998 4569 3240077
SGTC_2275 7947463 200 µM -2.306472319156 0.0269542238665654 no 3235 0.010542127554498 4713 1225414
SGTC_300 r073-0011 5.04 µM -2.31322068839607 0.0266032552797091 no 3236 0.0103552543346199 4748 2735780
SGTC_1146 3579-1023 7 µM -2.31407674916514 0.026559007429831 no 3237 0.0103317562768821 4738 X1146
SGTC_1838 st055369 84.5 µM -2.3200902380041 0.0262499136497814 no 3238 0.0101679981576772 4737 676036
SGTC_1051 3253-3903 78 µM -2.32943034827642 0.025775797845286 no 3239 0.009918139446212 4744 5509239
SGTC_2082 5219693 150 µM -2.33312928175587 0.0255900267852686 no 3240 0.00982068052041314 4720 2834649
SGTC_2276 7947513 42.08 µM -2.33726337760598 0.025383728528361 no 3241 0.00971274677023394 4687 2105100
SGTC_1929 genistein trimethyl ether 50.5 µM -2.34482531194296 0.0250099798304572 no 3242 0.0095179980465608 4724 136420
SGTC_2419 paclitaxel 166.5 µM -2.3488847325826 0.024811253262896 no 3243 0.00941486747639289 4711 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1775 st081588 35.1725 µM -2.34903288085601 0.0248040258719913 no 3244 0.00941112229012774 4723 1426443 YGL099W LSG1
SGTC_1539 benzyladenosine 56 µM -2.35352275870905 0.0245858241325168 no 3245 0.00929823472169398 4773 92208 A nucleotide analog.
SGTC_3004 9076122 71.4286 µM -2.35390974550426 0.024567092754497 no 3246 0.00928856052729746 4729 44782551
SGTC_701 4424-0219 185 µM -2.35698733885769 0.0244185534858163 no 3247 0.00921193750865629 4751 2911779
SGTC_649 1123-0311 367 µM -2.36769889224048 0.0239074290937828 no 3248 0.00894954826580495 4671 693629 YIL048W NEO1
SGTC_1230 0170-0365 3.77 µM -2.37699514384054 0.0234711559059304 no 3249 0.00872715895715227 4749 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1827 berberine 7.24 µM -2.37714493549532 0.0234641813829117 no 3250 0.00872361559568047 4689 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3125 9127534 49.47 µM -2.38221103847375 0.0232293207607678 no 3251 0.00860451601566181 4712 1639235
SGTC_1455 4262-0120 131 µM -2.39532329682437 0.0226306195021701 no 3252 0.00830285807953667 4756 1529587
SGTC_3036 9090181 49.47 µM -2.39707812142705 0.0225514904625176 no 3253 0.0082631998950381 4779 25236586
SGTC_82 0054-0107 293.755 µM -2.3988435947511 0.0224721167801506 no 3254 0.00822346904158466 4740 3104697
SGTC_3116 9124943 49.47 µM -2.41658372238194 0.0216875372986136 no 3255 0.00783346141719493 4743 41905195 YPL160W CDC60
SGTC_583 1488-1091 88.9 µM -2.41787422040967 0.0216313777005698 no 3256 0.00780573606202433 4786 4303273
SGTC_390 dec-rvkr-cmk 16.7 µM -2.43144695157803 0.0210481291638482 no 3257 0.00751932517856246 4757 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_122 0236-0016 402.397 µM -2.43683249844167 0.02082041705116 no 3258 0.00740827041380406 4737 6808838
SGTC_2623 humulene 100 µM -2.44826608379112 0.0203438890374362 no 3259 0.00717728019125878 4732 6187145 An anti-inflammatory.
SGTC_2989 9073649 71.4286 µM -2.45310140208996 0.0201451623189767 no 3260 0.00708152037165838 4723 21367202
SGTC_2598 perillyl alcohol 100 µM -2.45804159393476 0.0199438280363853 no 3261 0.00698484967383353 4743 10819 An apoptosis inducer.
SGTC_2268 7933382 153.85 µM -2.47144851397193 0.0194060223511213 no 3262 0.00672834634115932 4748 935025 YOR257W CDC31
SGTC_3104 9120930 49.47 µM -2.47732367518843 0.0191742575149459 no 3263 0.00661858983394502 4751 17014836
SGTC_2849 9019321 12.99 µM -2.48011207036923 0.0190650861977005 no 3264 0.00656705471522459 4741 16489627
SGTC_455 paf C-16 10 µM -2.4927403695039 0.0185772566687585 no 3265 0.00633807492086041 4743 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_666 0272-0154 136 µM -2.4995035605345 0.0183203935581853 no 3266 0.00621837246764022 4762 6870312
SGTC_705 1124-0212 310 µM -2.50467962118296 0.0181258586026176 no 3267 0.00612811776271784 4755 9554485
SGTC_3134 9127454 49.47 µM -2.51569670235254 0.0177176529305995 no 3268 0.00593986827359006 4758 24262820
SGTC_1822 st052468 42 µM -2.516664029802 0.017682189013331 no 3269 0.00592358697831891 4781 2873678
SGTC_1711 st032263 62.8 µM -2.51855523715241 0.0176130290027144 no 3270 0.00589186994570844 4772 3958979
SGTC_2963 9082507 9 µM -2.52756498659222 0.0172867107538837 no 3271 0.0057428282665652 4739 16459611
SGTC_2343 7990716 14.84 µM -2.53405246372266 0.0170549555601876 no 3272 0.00563759246664946 4745 6456862
SGTC_1512 0259-0544 12.2 µM -2.53538371252429 0.0170077285542945 no 3273 0.00561621073912009 4744 18476
SGTC_1184 1269-1718 139 µM -2.53658479782455 0.0169652151696725 no 3274 0.00559698145049516 4780 5403821
SGTC_1044 1222-0021 1.78 µM -2.55816253661431 0.0162167918649818 no 3275 0.0052613448257566 4717 4306703
SGTC_260 nsc-65238 3.989 µM -2.5667082868849 0.0159282998177569 no 3276 0.00513344719579232 4771 3246252
SGTC_1342 1486-1464 234 µM -2.57295456636809 0.015720228052315 no 3277 0.00504172218579783 4782 3253938
SGTC_929 2805-0021 398 µM -2.58569160954726 0.0153031565584405 no 3278 0.00485919197560858 4763 3098024
SGTC_20 0481-0013 4.944 µM -2.58695311489665 0.0152623708574633 no 3279 0.00484143832483903 4795 182045
SGTC_668 1682-0499 62.6 µM -2.59167192124714 0.0151106339996278 no 3280 0.00477554031402951 4769 682214
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -2.62942180833274 0.0139427555188857 no 3281 0.00427650992727246 4781 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1718 roemerine 11.9335 µM -2.63088879323211 0.0138989870026426 no 3282 0.00425809488162239 4495 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2451 5856223 45.7 µM -2.64989208894847 0.0133426309277662 no 3283 0.00402587418930537 4759 2179896
SGTC_1789 tunicamycin 25 nM -2.66574599945932 0.0128932993889276 no 3284 0.00384088536668969 4743 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.67565723188383 0.0126190932273171 no 3285 0.00372914399843755 4737 676296 Flavone; oxidizing agent.
SGTC_2272 7805186 180 µM -2.67698115978365 0.0125828500682763 no 3286 0.00371444060995017 4769 2956062 YPR165W RHO1
SGTC_3102 9121669 49.47 µM -2.70459624628501 0.0118471537501192 no 3287 0.00341937276038508 4783 41905072
SGTC_1486 3970-0793 4.53 µM -2.70807148126102 0.0117572669329046 no 3288 0.00338377223011839 4793 2844330
SGTC_2666 tannic acid 100 µM -2.73616633562445 0.0110520781177441 no 3289 0.00310797985871584 4772 16134267 A thiamine antagonist.
SGTC_197 4544-0043 41.561 µM -2.73992474150692 0.0109605885709399 no 3290 0.00307266270509856 4786 896523
SGTC_2136 5328288 199.296 µM -2.77401139258202 0.0101604800700005 no 3291 0.00276848695724144 4764 262395
SGTC_2236 dapsone 200 µM -2.78457796214425 0.00992302647998448 no 3292 0.0026798717236464 4780 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1665 st014639 11.4 µM -2.80215744911564 0.00953870512965218 no 3293 0.00253810463630945 4807 981133 YIL048W NEO1
SGTC_1709 st033179 39.1045 µM -2.80256780776745 0.00952989153215373 no 3294 0.00253487788804111 4791 573381
SGTC_1707 st032323 6.317 µM -2.80559659249923 0.00946505984654992 no 3295 0.00251117629324456 4664 3132057 YMR211W DML1
SGTC_1294 1000-1494 117 µM -2.8141244359088 0.00928458721560425 no 3296 0.0024455145743601 4788 712797 YDL207W GLE1
SGTC_2438 5259590 200 µM -2.81563759575402 0.00925288107715272 no 3297 0.00243402729917897 4782 1201127
SGTC_2264 7948757 110.76 µM -2.86377018693445 0.00829256560403138 no 3298 0.00209315808084671 4771 2971411
SGTC_980 1473-0395 201 µM -2.86695487241529 0.00823223139642885 no 3299 0.00207221052206635 4767 768876
SGTC_2726 cimetidine 79.27 µM -2.87466105665472 0.00808782973833064 no 3300 0.00202230714715879 4799 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2007 4011539 71.82 µM -2.87551641484255 0.00807193976382602 no 3301 0.00201683585736124 4771 45595301
SGTC_1289 0976-0073 69.1 µM -2.87954273706741 0.00799751085668057 no 3302 0.00199126158671874 4793 3391136
SGTC_1496 4469-0713 57.4 µM -2.88504660568203 0.00789674506917467 no 3303 0.00195677860521804 4794 746691
SGTC_79 0052-0007 94.094 µM -2.88648469733848 0.00787060093896658 no 3304 0.00194785845599406 4783 2801472
SGTC_1814 st052110 31.539 µM -2.89369015914114 0.00774075071657018 no 3305 0.00190371832793066 4770 674163
SGTC_1025 k007-0731 70 µM -2.90006385811974 0.00762746507744825 no 3306 0.00186543321805083 4778 6256118
SGTC_157 1348-1695 65.819 µM -2.92924524999414 0.00712723285512846 no 3307 0.00169893105227967 4749 5380510
SGTC_2429 5902844 64.44 µM -2.93156082666618 0.00708880719508205 no 3308 0.00168631656148454 4787 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_98 0074-0023 107.663 µM -2.94126428452088 0.00692976477861279 no 3309 0.00163437757962838 4779 3563821
SGTC_2675 theaflavin digallate 100 µM -2.99758508967031 0.00606738330972357 no 3310 0.00136063939989913 4771 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_73 0327-0325 16.231 µM -3.00146427447735 0.00601164713075164 no 3311 0.00134342282406382 4706 53298
SGTC_901 1112-0062 60.1 µM -3.02086551680832 0.00573964605697304 no 3312 0.00126026640931556 4795 1908457
SGTC_1658 st012944 20 µM -3.02328419629308 0.00570651417704124 no 3313 0.00125023649325935 4723 24207260
SGTC_1477 0139-0234 16 µM -3.03262655390168 0.00558012821837249 no 3314 0.00121217708874695 4799 620880
SGTC_1317 1273-0028 910 nM -3.0791261146143 0.00498733046202083 no 3315 0.00103804388432075 4791 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2442 5158906 48.48 µM -3.09951658364573 0.00474556983201749 no 3316 0.00096918363081883 4789 1893835
SGTC_1547 harmine 94.2 µM -3.15525140319765 0.00413720927182217 no 3317 0.000801799301641947 4752 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_922 1866-0035 480 µM -3.22993732132376 0.00343161650376358 no 3318 0.000619086796181888 4774 3156169
SGTC_129 0088-0017 176.636 µM -3.23472142898132 0.00339034029361758 no 3319 0.000608807326399038 4774 182446
SGTC_1511 0906-3109 28.5 µM -3.23733666344258 0.00336796575441954 no 3320 0.000603254921190896 4795 2882180
SGTC_398 bronopol 33.3 µM -3.26083987810111 0.00317276415634125 no 3321 0.000555413749520508 4776 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_37 0566-0070 1.56 µM -3.29827202374444 0.00288283047005927 no 3322 0.000486409201921807 4790 1626686
SGTC_1774 st048371 48.465 µM -3.298411625054 0.00288179543135716 no 3323 0.000486167409903145 4799 4242727
SGTC_2516 gossypol 71.55 µM -3.30808158891179 0.00281091026720858 no 3324 0.000469687190122228 4794 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_703 3875-0075 71.8 µM -3.37488645436222 0.0023626612487882 no 3325 0.000369230761654059 4806 2850814
SGTC_1286 0929-0070 131 µM -3.446402517375 0.00195539696383773 no 3326 0.000284051743164136 4801 1420408
SGTC_1330 1469-0054 61.8 µM -3.45249001346739 0.00192386185953743 no 3327 0.000277719018048792 4803 7102664
SGTC_255 tunicamycin 200.472 nM -3.46398462711045 0.00186557318155869 no 3328 0.000266118463022916 4786 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_982 1491-0518 27.5 µM -3.47819396959676 0.00179573887399217 no 3329 0.000252402245383818 4807 3091256
SGTC_1300 1094-0077 113 µM -3.52466298758383 0.00158363986529203 no 3330 0.000212010936057805 4806 5532636
SGTC_829 1635-0120 117 µM -3.52962773911967 0.00156238504776984 no 3331 0.000208072378549011 4798 285054
SGTC_2595 hexamethylquercetagetin 100 µM -3.54317022680345 0.00150572326050015 no 3332 0.000197673710096181 4791 386331
SGTC_2053 5265679 138 µM -3.61596885075441 0.00123199919790589 no 3333 0.000149613179251393 4793 764595
SGTC_2991 9074669 71.4286 µM -3.63363099380612 0.00117284982726367 no 3334 0.000139730231496595 4783 17333109
SGTC_2603 homopterocarpin 100 µM -3.66912303293068 0.00106177928829421 no 3335 0.000121691967284167 4792 101795 A weak amylase inhibitor.
SGTC_917 harmaline 728.087 nM -3.67535421311281 0.00104330495349237 no 3336 0.000118759821681521 4768 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2300 7976697 71.57 µM -3.70275465876763 0.000965514960752409 yes 3337 0.000106635553136172 4779 2236109
SGTC_2267 7931562 200 µM -3.7126307582602 0.000938808300710748 yes 3338 0.000102558014280877 4794 934880
SGTC_3078 9116413 49.47 µM -3.71825696079874 0.000923899172424232 yes 3339 0.000100301081291898 4795 17177322
SGTC_2507 purpurin 79.67 µM -3.96402455194151 0.000449857787319346 yes 3340 3.68483340014989e-05 4807 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1514 1189-1591 158 µM -4.09478827597868 0.000301788634343803 yes 3341 2.11277177759935e-05 4809 767698 YMR146C TIF34
SGTC_1785 bathophenanthroline 24 µM -4.19780422734378 0.000218597733022126 yes 3342 1.34757731236743e-05 4799 72812 An iron chelator.
SGTC_2582 agaric acid 100 µM -4.23101978445393 0.00019671289403794 yes 3343 1.16317103434925e-05 4721 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3152 9099253 49.47 µM -4.24720722808613 0.000186805844606631 yes 3344 1.08225868997671e-05 4762 25236131
SGTC_2755 lomerizine 42.69 µM -4.27919293244722 0.000168586280782251 yes 3345 9.37861101183372e-06 4797 3949 A calcium channel blocker.
SGTC_1936 st074407 74.3 µM -4.33759088779202 0.000139536256363957 yes 3346 7.20264860273044e-06 4805 809813
SGTC_44 0929-0055 61.211 µM -4.63444524002238 5.15055934983609e-05 yes 3347 1.78947977242489e-06 4738 1379590
SGTC_40 0327-0103 19.753 µM -4.8250608655526 2.63261213883145e-05 yes 3348 6.99802593441058e-07 4788 409036
SGTC_2266 7929956 200 µM -4.95318832484785 1.6538608469963e-05 yes 3349 3.65036272687844e-07 4806 2967153
SGTC_2690 usnic acid 100 µM -5.0086909451398 1.34757162968719e-05 yes 3350 2.74007448106011e-07 4809 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_299 1273-0059 1.44 µM -5.13496824110267 8.39104589477053e-06 yes 3351 1.41095836532658e-07 4781 2848077
SGTC_453 enantio-paf c16 10 µM -5.25793576667943 5.23565450188922e-06 yes 3352 7.28406912261379e-08 4676 13871343 A lipid and platelet activating factor
SGTC_1786 berberine 21.6 µM -5.46658679279886 2.29724415336694e-06 yes 3353 2.29391917502675e-08 4807 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_393 acivicin 6.25 µM -5.53991540651986 1.70775695389432e-06 yes 3354 1.51308895605321e-08 4809 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3037 9091026 49.47 µM -5.91037044944551 3.61020622731901e-07 yes 3355 1.70669607367035e-09 4804 25236398 YIL048W NEO1
SGTC_310 1273-0058 1.06 µM -7.94607249393081 1.31786011401382e-11 yes 3356 9.62588943055571e-16 4782 2734232